Miracle-dz/UniFAR-FTUs huggingface dataset:
Patients and relatives desire their physician to give a judgement about driving abilities: a survey by questionnaire on a Dutch memory clinic

Dementia is a progressive disease, with implications for driving ability and the eventual need for restricting or ceasing driving in people with dementia. A critical issue in the management of dementia is when to recommend restrictions on driving an automobile. This article reports on a study that considered whether relatives and patients prefer a judgment from their physician considering the ability to drive. The questionnaire study included 100 consecutive patients and 97 accompanying relatives who attended an outpatient memory clinic at a Dutch teaching hospital. The results showed that, when necessary in the case of a somatic disease or dementia, almost all patients and their relatives expect a physician to revoke driving privileges.
Secretion of Serratia liquefaciens phospholipase from Escherichia coli

The Serratia liquefaciens phospholipase (PhIA) is secreted to the medium from its natural host. Here we present results which indicate that, when cloned and expressed in Escherichia coli, secretion can be mediated by a putative host‐encoded pathway, expression of which is controlled by FlhD (formerly FlbB), the master regulator of the flagellar/ chemotaxis regulon. In the absence of this secretion pathway, the synthesized phospholipase accumulates inside the host cell where it forms a complex with the PhlB protein. PhlB, which is encoded from the promoter distal gene of the phospholipase operon, inhibits the phospholipase activity of PhlA. Formation of this enzymatically inactive PhlA/PhlB complex is required for maintenance of cell viability.
The interpretation of results of economic evaluation: explicating the value of health.

Theoretically it can be proven that an optimal allocation of resources within a constrained budget can be reached by considering cost-effectiveness ratios (CERs). In this paper, the complex priority setting process regarding compatible and incompatible alternatives of medical interventions is clarified. Priority setting in the context of compatible alternatives may refer to the selection of more than one, possibly all, alternatives. Inherent to a set of incompatible alternatives is that only one alternative can be selected. This latter situation frequently occurs in health care. The value that society attaches to a unit of effectiveness (e.g. a QALY) has an important impact on the priority ranking of medical interventions. By explicating this value and by using the 'net-value' approach, a graphical framework is presented that allows decision-makers a better understanding on the impact of particular levels of these values on their optimal policy choices. For illustrative purposes, it is shown that by the erroneous application of decision rules, some recent papers have provided sub-optimal recommendations for health care policy.
Fictitious Play: A Statistical Study of Multiple Economic Experiments

This paper illustrates the use of a full Bayesian procedure to update an experimenter's belief over various economic behavioral hypotheses using data from a variety of (potentially very different) experiments. Our example uses experimental data to update our belief as to whether individuals select strategies according to fictitious play. We endow the experimenter with priors over the events that players act according to fictitious play and according to the Cournot process. We then numerically compute the likelihood function for each experiment by replicating the experimental design and running the experiment with robots that behave according to each of our hypotheses. Updating experiment by experiment shows that some of the experiments favor Cournot, but most of them favor fictitious play as the more likely hypothesis. This illustrates the limitations of a classical procedure that can take only one experiment into consideration since some of the experiments may be misleading. Indeed, when we did the overall updating using 9 experiments, we found that, for any priors, the overall posterior put probability very close to one on the individuals acting according to fictitious play. Given the heterogeneity in the payoffs and design of the experiments that we combine for that overall posterior, it is clear that there is no classical procedure that would offer the same type of information.
Pedagogical practices and instructional change of physics faculty

We report on the initial results of a web-based survey of 722 physics faculty in the United States regarding their instructional practices. The survey responses indicate that most faculty report knowing about many physics education research curricula and pedagogies and are interested and motivated to try them in their teaching. However, self-reports of actual classroom practices indicate that the availability of these curricula and pedagogies has not led to fundamental changes in instruction. Faculty report that time is the biggest impediment to implementing more research-based reforms. These results suggest a need for research-based dissemination that accounts for the complexity of instructional change.
Insertional translocation detected using FISH confirmation of array‐comparative genomic hybridization (aCGH) results

Insertional translocations (ITs) are rare events that require at least three breaks in the chromosomes involved and thus qualify as complex chromosomal rearrangements (CCR). In the current study, we identified 40 ITs from approximately 18,000 clinical cases (1:500) using array‐comparative genomic hybridization (aCGH) in conjunction with fluorescence in situ hybridization (FISH) confirmation of the aCGH findings, and parental follow‐up studies. Both submicroscopic and microscopically visible IT events were detected. They were divided into three major categories: (1) simple intrachromosomal and interchromosomal IT resulting in pure segmental trisomy, (2) complex IT involving more than one abnormality, (3) deletion inherited from a parent with a balanced IT resulting in pure segmental monosomy. Of the cases in which follow‐up parental studies were available, over half showed inheritance from an apparently unaffected parent carrying the same unbalanced rearrangement detected in the propositi, thus decreasing the likelihood that these IT events are clinically relevant. Nevertheless, we identified six cases in which small submicroscopic events were detected involving known disease‐associated genes/genomic segments and are likely to be pathogenic. We recommend that copy number gains detected by clinical aCGH analysis should be confirmed using FISH analysis whenever possible in order to determine the physical location of the duplicated segment. We hypothesize that the increased use of aCGH in the clinic will demonstrate that IT occurs more frequently than previously considered but can identify genomic rearrangements with unclear clinical significance. © 2010 Wiley‐Liss, Inc.
Improved selectivity of double quantum coherence filtering for the detection of glutathione in the human brain in vivo

An improved double quantum coherence (DQC) filter for the selective in vivo detection of glutathione (GSH) in the human brain at 1.5 Tesla is presented. The goal was to minimize contamination of the DQC‐filtered GSH signal at 2.9 ppm with contributions arising from GABA. The modification consists of tailoring the frequency response of the read pulse, which converts DQC into anti‐phase single quantum coherence in such a way that the GABA β and γ resonances at 3.0 and 1.9 ppm, respectively, remain unaffected. An implementation incorporating a Dante pulse train is used for in vitro tests as well as for in vivo applications. Magn Reson Med 45:708–710, 2001. © 2001 Wiley‐Liss, Inc.
Quality Assessment of Interaction Techniques in Immersive Virtual Environments Using Physiological Measures

This paper presents a new methodology for quality assessment of interaction techniques in immersive virtual environments, based on the study of the relationships between physiological measures and usability metrics using multivariate data analysis. Our methodology defines a testing protocol, a normalization procedure and statistical techniques, considering the use of physiological measures during the evaluation process. A case study comparison between two 3D interaction techniques (ray-casting and HOMER) shows promising results, pointing to heart rate variability, as measured by the NN50 parameter, as a potential index of task performance. Besides, this study also shows that heart rate (HR) and skin conductance (SC) measures reflect the user's task performance during the interaction process. Despite these results, this work reveals that physiological measures still cannot be considered as substitutes of evaluation metrics for 3D interfaces, but may be useful in the interpretation and understanding process of them. Discussions also indicate the further studies are needed to establish guidelines for evaluation processes based on well-defined associations between human behaviors and human actions realized in 3D user interfaces.
Toxicity of preserved and unpreserved antiglaucoma topical drugs in an in vitro model of conjunctival cells. De saint jean M, debbasch C, brignole F, rat P, warnet J-M, baudouin C.* curr eye res 2000;20:85-94

Purpose. To compare the toxicity of a short-time application of timolol with benzalkonium chloride (timolol-BAC+) and unpreserved timolol (timolol-BAC-) in a human conjunctival cell line. Methods. Chang’s conjunctival cell line (ATCC CCL 20.2) was treated for 15min. with 0.1%, 0.25% or 0.4% timolol-BAC(+) or BAC(-) and then examined immediately or 24h later. Cell viability, chromatin condensation and free radicals production were studied by microplate cold light cytometry. Moreover, relative cell number was evaluated by crystal violet colorimetric test. The comparison was done with an oxidative stress model of cells treated with 0.001–0.000001% hydrogen peroxide (H 2 O 2) . In addition, cell size and the expression of an apoptotic marker Apo2.7 were evaluated by flow cytometry. Results. Timolol-BAC(+) induced a rapid decrease in cell viability ranging from 40% immediately after treatment to 85% 24h later. A small initial decrease in cell viability was also observed with all tested concentrations of timolo.
Pathology of cytoskeleton of liver cells: Demonstration of mallory bodies (alcoholic hyalin) in murine and human hepatocytes by immunofluorescence microscopy using antibodies to cytokeratin polypeptides from hepatocytes

A cytoskeleton fraction enriched in intermediate‐sized filaments and resistant to high and low salt buffer containing Triton X‐100 was prepared from dissociated mouse liver cells and mouse liver homogenates. One‐dimensional sodium dodecyl sulfate‐polyacrylamide gel electrophoresis revealed a family of polypeptides in the relative molecular weight (Mr) range from 41,000 to 55,000, with two polypeptides (component A, Mr 55,000; component D, Mr 48,000) as major constituents. Antibodies to isolated cytokeratin components of lower molecular weights (48,000 and 45,000 to 41,000) decorated, in indirect immunofluorescence microscopy, a distinct cytoplasmic filament meshwork in hepatocytes of various species whereas antibodies to higher molecular weight components were less or even not effective. The antibodies also reacted with cytokeratin filaments present in epithelial cells of various other organs and species, confirming the widespread occurrence of immunologically related cytokeratin filaments in epithelial tissues. The antibodies to higher molecular weight components showed a higher affinity to cytokeratin filaments of epidermis, stratified epithelia, and myoepithelial cells compared to epithelial cells of other organs, including small intestinal crypt epithelium and secretory cells of the submandibular gland. These observations further support the biochemical and immunologic heterogeneity in the cytokeratin family.
Towards Formalizing of MapReduce

As a powerful distributed computing model, MapReduce has been widely used in many domains to process massive amounts of data. To ensure its correctness, one of the appropriate ways is formal methods. In this paper, we will propose a formal language to model MapReduce Programs based on our previous work. The language describes the MapReduce programming model from a view of files and blocks. So the details of data processing during a MapReduce computation can be clearly demonstrated. Certainly some parallel commands are introduced to reflect the parallelization of the computation. Based on this language, the correctness verification of the MapReduce programming model can be developed.
Origin of soft-mode stiffening and reduced dielectric response in SrTiO3 thin films

The problem of the reduced dielectric response in thin films of high-permittivity materials is analyzed by studying the soft-mode response in several ${\mathrm{SrTiO}}_{3}$ thin films by means of Fourier transform far infrared, monochromatic submillimeter, and micro-Raman spectroscopies. A 300-nm-thick metalorganic chemical vapor deposition film, quasiepitaxially grown on a (0001) sapphire substrate with a perfect 〈111〉 orientation, displays a ferroelectric transition near 125 K induced by a tensile residual stress, appearing apparently simultaneously with the antiferrodistortive transition. On the other hand, polycrystalline chemical solution deposition films grown on (0001) sapphire, and also tensile stressed, show a harder soft mode response without the appearance of macroscopic ferroelectricity. This effect, which increases with the film thickness, is explained by a strong depolarizing field induced by the percolated porosity and cracks (in the 10-nm scale) along the boundaries of columnar grains (normal to the probe field direction). Brick-wall model calculations showed that 0.2 vol. % of such a porosity type reduces the permittivity from 30000 to less than 1000. The activation of the forbidden IR modes in the Raman spectra in the whole 80--300-K temperature range studied is explained by the effect of polar grain boundaries, in analogy with the bulk ceramics.
Crowd Escape Behavior Detection and Localization Based on Divergent Centers

In this paper, we propose a novel framework for anomalous crowd behavior detection and localization by introducing divergent centers in intelligent video surveillance systems. In this paper, the scheme proposed can deal with this problem by modeling the crowd motion obtained from the optical flow. The obtained magnitude, position and direction are used to construct the motion model. The method of the weighted velocity is applied to calculate the motion velocity. People usually instinctively escape from a place where abnormal or dangerous events occur. Based on this inference, a novel algorithm of detecting divergent centers is proposed: divergent centers indicate possible places where abnormal events occur. The proposed algorithm of detect divergent centers can identify more than one divergent center by analyzing the intersections of vectors, and this algorithm consist of the distance segmentation method and the nearest neighbor search. The performance of our method is validated in a number of experiments on public data sets.
Patients` evaluation for the surgical management of nasal obstruction.

STATEMENT OF PROBLEM Surgery for nasal obstruction is performed to give a subjective benefit. We aimed to evaluate the surgical management of the nasal obstruction in the patient`s perception. METHODS OF STUDY The study was performed prospectively with 134 patients over the age of 18. They were allotted to three groups according to the level of nasal obstruction by clinical examination. The G1 group had only a deviated nasal septum (DNS), G2 had DNS and hypertrophy of inferior turbinates, and G3 had nasal valve problems in conjunction with DNS. All the patients had surgery focused on obstructive pathologies. The study was conducted using three different scoring systems to determine the patients` evaluation of the surgical procedures. RESULTS The study included more man than woman, with a mean age around 28 (wide range). Twenty six patients were in G1, 73 patients in G2 and 35 patients in G3. Total and general Glasgow Benefit Inventory (GBI) scores for each group showed improvement postoperatively. There was a significant difference between the groups for general GBI score, and Post-hoc test showed that the improvement of G1 was greater than of G3. The influence of the surgery on physical health, psycho-social function and social interaction scores for each group showed no changes postoperatively. There was a significant improvement in all Nasal Obstruction Septoplasty Effectiveness (NOSE) scores and Likert Scale scores for each group. The improvement of G1 and G2 were greater than G3 on the Likert Scale. CONCLUSION Surgical management targeted to the region of obstruction improves symptoms and benefit in the patient`s perception.
A millimeter-wave sequential power amplifier

In this paper, we present a millimeter-wave sequential power amplifier (SPA) at the frequency of 26GHz for the first time. The proposed SPA consists of a 3dB power divider, two GaAs power amplifier chips acting as the main and peaking amplifier respectively, and an 8dB output coupler. Measurement results show 6dB back-off efficiency of 18.5% and peak output power of 24.4dBm at 26GHz. The frequency response from 26GHz to 27GHz is also given, and 6dB back-off efficiency better than 18% is achieved from 26GHz to 27GHz.
Cloning of Hepadnaviruses using microquantity serum.

The Hepadnaviruses includes the human hepatitis B virus (HBV) and duck hepatitis B virus (DHBV) which are enveloped and characterised by a circular partially double stranded DNA of 3 kb to 3.2 kb in length. The long complete strand is termed the negative strand, while the short, partially complete, strand covering 50-70% ofthe genome is the positive strand. The most frequently encountered problems in cloning of Hepadnaviruses are the availability of large quantities of serum/plasma and the purification of the virus. A simple and efficient method for cloning of viral DNA from micro-quantities of serum is described which circumvents these problems.
Mobile Voronoi Diagrams for Traffic Monitoring under Bad Visibility Conditions

A semiautomatic management of traffic scenes displays a large diversity of mobile data arising from usual Computer Vision techniques. The mobile nature of inputs requires the combination of different techniques for filtering, tracking, and clustering features along a video sequence. These problems are considerably harder in presence of low visibility conditions arising from rain, fog or dazzling conditions. It is necessary a robust coarse-to-fine approach for supporting early alert in presence of conflict or dangerous situation at road intersections. Currently, there is no a general solution developed for low visibility conditions, and what there is, has been developed following particular strategies involving a specific combination of filters for extracting and analyzing the situation. Under low visibility conditions, mobile features are clustered as blobs with similar motion patterns and labelled in terms of a mobile Voronoi site which represents the centroid of a coloured region with similar kinematic pattern. For a fixed camera, and in absence of information about relative velocities of vehicles, kinematic involves the relative variation of colour and shape. With low visibility conditions and for real-time response, it is not necessary to work with a large palette of colours, and a reduction of bits per pixel is performed in the preprocessing stage. We illustrate our results with some scenes where reflections in water (rainy weather) or discontinuities linked to fog, can produce hallucinations for which our approach provides a robust kinematic method justifying the application of mobile Voronoi diagrams for mobile blobs as unifying principle.
Analysis of Histones Associated with Neuronal and Glial Nuclei Exhibiting Divergent DNA Repeat Lengths

Abstract: Total cerebral hemisphere nuclei purified from adult rabbit brain were subfractionated into neuronal and glial populations. Previous studies have shown that chromatin in neuronal nuclei is organized in an unusual nucleosome conformation compared with glial or kidney nuclei, i.e., a short DNA repeat length is present. We now analyze whether this difference in chromatin organization is associated with an alteration in the histone component of nucleosomes. Total histone isolated by acid/urea‐protamine extraction of purified neuronal, glial, and kidney nuclei was analyzed by electrophoresis on SDS‐polyacrylamide slab gels. Histone H1 that was selectively extracted from nuclei was also examined. Differences were not observed on SDS gels in the electrophoretic mobilities of histones associated with either the nucleosome core particle (histones H2A, H2B, H3, H4) or the nucleosome linker region (histone H1). Total histone and selectively extracted histone H1 were also analyzed on acid/urea slab gels that resolve histones on the basis of both molecular weight and charge differences. When analyzed in this system, differences with respect to electrophoretic mobility were not detected when comparing either selectively extracted histone H1 or total histone from neuronal and glial nuclei. Quantitative analyses were also performed and neuronal nuclei were found to contain less histone H1 per milligram DNA compared with glial or kidney nuclei. Neuronal nuclei also demonstrated a lower ratio of histone H1/core histone. These results suggest that the pronounced difference in chromatin organization in neuronal compared with glial nuclei, which is reflected by a short DNA repeat length in neurons, appears to be associated with quantitative differences in neuronal histone H1.
Differential effect of glimepiride and rosiglitazone on metabolic control of type 2 diabetic patients treated with metformin: a randomized, double‐blind, clinical trial

Aim: Accumulating evidence suggests that combination therapy using oral antidiabetic agents with different mechanisms of action may be highly effective in achieving and maintaining target blood glucose levels. The aim of our study is to evaluate the differential effect on glucose and lipid parameters of the association between glimepiride plus metformin and rosiglitazone plus metformin in patients affected by type 2 diabetes and metabolic syndrome.