Miracle-dz/UniFAR-FTUs huggingface dataset:
Novel Way of Explaining the Theory of the Expansion of the Universe in the Absence of Dark Energy

In this work, a new theory is shown in which the approach that leads to this would be relatively easier to demonstrate experimentally. In this theory, we propose that we should carefully observe the fundamental forces and constants of the universe, since the answer to the problem of the behaviour of expansion of the universe, may lie in the functioning of these fundamental forces and constants. We currently take as the fundamental forces, they carry with them constant values assigned to these forces, as for example the constant of universal gravitation, the electric constant, etc. Despite this, a doubt arises in our knowledge and is: What would happen in the event that these constants that we usually take as fixed values were variable, but with constant "patterns" throughout certain periods of space-time (on a cosmological scale)? In this article we can take as a point of reference the fundamental forces that we have as concepts today, which would be the electromagnetic force, the gravitational force, the strong and weak nuclear force, however we deal with gravity as if it were a property of the matter instead of a fundamental force, the constants related to the fundamental forces, even the same speed of light, can change depending on the place where they are measured, the scale and the conditions in which these measurements are realized. For this reason, that we propose the possibility of undergoing certain changes as they advance on a reference scale with respect to time and space, based on this we propose an alternative to dark energy (theory of the modified gravity MOG) arguing how, from tiny changes in the values of these fundamental forces would appropriately justify inflation of the early universe, the subsequent deceleration and the acceleration that we show today of the universe. (Dark matter, dark energy, expansion of the universe, theory of modified gravity MOG, early universe.)
The Impact of IOL Abbe Number on Polychromatic Image Quality of Pseudophakic Eyes

Purpose The human eye exhibits large amounts (2.5 diopters) of longitudinal chromatic aberration (LCA). Its impact on polychromatic image quality, however, has been shown experimentally and by computer modeling to be small or absent. We hypothesized that modest changes in pseudophakic LCA created by higher and lower Abbe number materials will have little or no impact on polychromatic image quality in pseudophakic eyes. Materials and Methods Using published chromatic and monochromatic aberration data from pseudophakic eyes and higher and lower Abbe number materials (37 and 55), we computed monochromatic point spread functions for 21 wavelengths across the visible spectrum. After weighting by either the RGB spectra of a liquid crystal display or by a flat white spectrum, they were weighted by the human spectral sensitivity function (Vλ) before being added to generate polychromatic PSFs. Results In the absence of monochromatic aberrations, the reduced LCA due to higher Abbe number intraocular lens (IOL) materials resulted in a reduction of 0.08 diopters in the mean defocus generated by LCA. At the retinal plane, the higher Abbe number pseudophakic model produced improvements in polychromatic modulation transfer functions (MTFs) similar to those generated by a 0.05 diopter reduction in spherical defocus. When monochromatic aberrations were added to make the model more representative of actual pseudophakic eyes, the differences in image quality became sub-threshold for human vision or disappeared completely. Conclusion The anticipated gains in polychromatic image quality from employing higher Abbe number IOL materials with reduced LCA do not materialize in plausible aberrated models of pseudophakic eyes.
Brothers in Arms: Structure, Assembly and Function of Arenaviridae Nucleoprotein

Arenaviridae is a family of viruses harbouring important emerging pathogens belonging to the Bunyavirales order. Like in other segmented negative strand RNA viruses, the nucleoprotein (NP) is a major actor of the viral life cycle being both (i) the necessary co-factor of the polymerase present in the L protein, and (ii) the last line of defence of the viral genome (vRNA) by physically hiding its presence in the cytoplasm. The NP is also one of the major players interfering with the immune system. Several structural studies of NP have shown that it features two domains: a globular RNA binding domain (NP-core) in its N-terminal and an exonuclease domain (ExoN) in its C-terminal. Further studies have observed that significant conformational changes are necessary for RNA encapsidation. In this review we revisited the most recent structural and functional data available on Arenaviridae NP, compared to other Bunyavirales nucleoproteins and explored the structural and functional implications. We review the variety of structural motif extensions involved in NP–NP binding mode. We also evaluate the major functional implications of NP interactome and the role of ExoN, thus making the NP a target of choice for future vaccine and antiviral therapy.
Association of Cardiovascular Risk Assessment with Early Colorectal Neoplasia Detection in Asymptomatic Population: A Systematic Review and Meta-Analysis

Abstract Previous studies have shown a strong coexistence of colorectal neoplasia (CRN) and cardiovascular diseases (CVD). This study was aimed to summarize the available evidence on association of CVD risk with early CRN detection in asymptomatic populations. PubMed, Web of Science, and Embase were systematically searched for eligible studies published until Dec 20, 2019. Studies exploring the associations of recommended CVD risk assessment methods (e.g., risk scores, carotid artery plaque, and coronary artery calcium score [CACS]) with risk of CRN were included. Meta-analyses were conducted to determine the overall association of CVD risk with the CRN. A total of 12 studies were finally included. The association of carotid artery plaque with the risk of colorectal adenoma (AD) was weakest (pooled odds ratio [OR)] 1.27, 95% confidence interval [CI), 1.12, 1.45]. Participants with CACS>100 had about 2-fold increased risk of AD than those with CACS=0. The pooled ORs were 3.36 (95% CI, 2.15, 5.27) and 2.30 (95% CI, 1.69, 3.13) for the risk of advanced colorectal neoplasia (AN) and AD, respectively, in participants with Framingham risk score (FRS)>20%, when compared to participants at low risk (FRS<10%). FRS might help identify subgroups at increased risk for AN, but further studies are needed.
Iron(II) phthalocyanine Loaded and AS1411 Aptamer Targeting Nanoparticles: A Nanocomplex for Dual Modal Imaging and Photothermal Therapy of Breast Cancer

Purpose A multi-functional nanoplatform with diagnostic imaging and targeted treatment functions has aroused much interest in the nanomedical research field and has been paid more attention in the field of tumor diagnosis and treatment. However, some existing nano-contrast agents have encountered difficulties in different aspects during clinical promotion, such as complicated preparation process and low specificity. Therefore, it is urgent to find a nanocomplex with good targeting effect, high biocompatibility and significant therapeutic effect for the integration of diagnosis and treatment and clinical transformation. Materials and Methods Nanoparticles (NPs) targeting breast cancer were synthesized by phacoemulsiﬁcation which had liquid ﬂuorocarbon perﬂuoropentane(PFP) in the core and were loaded with Iron(II) phthalocyanine (FePc) on the shell. The aptamer (APT) AS1411 was outside the shell used as a molecular probe. Basic characterization and targeting abilities of the NPs were tested, and their cytotoxicity and biological safety in vivo were evaluated through CCK-8 assay and blood bio-chemical analysis. The photoacoustic (PA) and ultrasound (US) imaging system were used to assess the effects of AS1411-PLGA@FePc@PFP (A-FP NPs) as dual modal contrast agent in vitro and in vivo. The effects of photothermal therapy (PTT) in vitro and in vivo were evaluated through MCF-7 cells and tumor-bearing nude mouse models. Results A-FP NPs, with good stability, great biocompatibility and low toxicity, were of 201.87 ± 1.60 nm in diameter, and have an active targeting effect on breast cancer cells and tissues. With the help of PA/US imaging, it was proved to be an excellent dual modal contrast agent for diagnosis and guidance of targeted therapy. Meanwhile, it can heat up under near-infrared (NIR) laser irradiation and has achieved obvious antitumor effect both in vitro and in vivo experiments. Conclusion As a kind of nanomedicine, A-FP NPs can be used in the integration of diagnosis and treatment. The treatment effects and biocompatibility in vivo may provide new thoughts in the clinical transformation of nanomedicine and early diagnosis and treatment of breast cancer.
Four Challenges Associated With Current Mathematical Modeling Paradigm of Infectious Diseases and Call for a Shift

Abstract Mathematical models are critical tools to characterize COVID-19 dynamics and take action accordingly. We identified 4 major challenges associated with the current modeling paradigm (SEIR) that hinder the efforts to accurately characterize the emerging COVID-19 and future epidemics. These challenges included (1) lack of consistent definition of “case”; (2) discrepancy between patient-level clinical insights and population-level modeling efforts; (3) lack of adequate inclusion of individual behavioral and social influence; and (4) allowing little flexibility of including new evidence and insights when our knowledge evolved rapidly during the pandemic. Therefore, these challenges made the current SEIR modeling paradigm less practical to handle the complex COVID-19 and future pandemics. Novel and more reliable data sources and alternative modeling paradigms are needed to address these issues.
Oral and Oropharyngeal Cancers and Possible Risk Factors Across Gulf Cooperation Council Countries: A Systematic Review

Background In recent years, there is an emerging increase in the prevalence of oral and oropharyngeal cancers (O-OPCs) across the Arabian Gulf Cooperation Council (GCC) countries. Consequently, this review aimed to explore the epidemiology and possible risk factors of O-OPCs in GCC countries. Methods Data published after 2008 related to O-OPCs in GCC countries were obtained through electronic searches in Medline/PubMed, Scopus, Web of Science, EMBASE and Google Scholar. Keywords related to the association between O-OPCs metrics (epidemiology and risk factors) and GCC countries were used for electronic searches. Results The overall prevalence of OPCs increased significantly over time (40-51%) in some countries (Saudi Arabia and Arab Emigrated) of the Gulf regions. The pooled risk factor was 3.4 (2.5 - 4.7). Among the risk factors, human papillomavirus and the use of smoke and smokeless tobacco revealed odds ratio (OR) 3.31 (3.13 - 4.5) and 0.60 (0.45 - 0.80) at 95% confidence interval (CI). Conclusion A positive correlation between factors like age, diet, hygiene, genetics, viral and bacterial infection, consumption of alcohol and tobacco products with OPC-MFC is suggested.
Instant Gratification as a Method to Promote Physician Practice Guideline Adherence: A Systematic Review

Inadequate adherence to best practice guidelines may have a negative impact on the processes of critical care and patient outcomes. Instant gratification has been used to modify human behavior in industries such as gaming, lottery, and social media. We hypothesize that, if properly and purposefully utilized, IG can become a successful tool for encouraging best practice guideline adherence among critical care providers. Four major databases were searched with a medial librarian. Covidence application was used to identify studies pertaining to the instant gratification being used to improve provider adherence with best practice guidelines. A total of 712 studies were identified, and, through duplicates removal, title and abstract screening, and full-text screening, a total of 13 studies were included in the final review. The exclusion criteria used included the following: no provider gratification, wrong focus/intervention, wrong study design, patient-focused intervention, not generalizable, and no conclusion. There is a knowledge gap regarding instant gratification utilization to influence practice guideline adherence among providers. The intervention functions of the Behavior Change Wheel (BCW) were evident, especially ‘persuasion’ and ‘incentivization’, which are most pertinent to our field. The restorative process that promotes positive reinforcement can be a potential solution for alleviating inadequacies in guideline adherence. Examining interventions based on functions of the BCW has shown that an instant gratification process may have the potential in altering critical care providers’ behavior and improving guideline adherence. This review is the first step towards creating smart algorithms to instantly alert providers for their actions compliant with best practices. Developing, testing, and validating the algorithms will be the next several steps.
The Mutation of the Genes Related to Neurovirulence in HSV-2 Produces an Attenuated Phenotype in Mice

HSV-2 (Herpes simplex virus type 2) is a critical viral agent that mainly causes genital herpes and life-long latent infection in the dorsal root ganglia. Gene modification via CRISPR/Cas9 Clustered regularly interspaced short palindromic repeat sequences/CRISPR associated 9) was used here to construct HSV-2 mutant strains through the deletion of fragments of the RL1 (Repeat Long element 1) and/or LAT (Latency-associated Transcript) genes. The HSV-2 mutant strains LAT-HSV-2 and RL1-LAT-HSV-2 present different biological properties. The proliferation of RL1-LAT-HSV-2 in nerve cells was decreased significantly, and the plaques induced by RL1-LAT-HSV-2 in Vero cells were smaller than those induced by LAT-HSV-2 mutant and wild-type strains. The observation of mice infected with these two mutants compared to mice infected with the wild-type strain indicated that the mutant RL1-LAT-HSV-2 has an attenuated phenotype with reduced pathogenicity during both acute and latent infections and induces a stronger specific immune response than the wild-type strain, whereas the attenuation effect was not found in mice infected with the LAT-HSV-2 mutant containing the LAT gene deletion. However, the simultaneous mutation of both the RL1 and LAT genes did not completely restrict viral proliferation in nerve cells, indicating that multiple HSV genes are involved in viral replication in the neural system. This work suggests that the HSV-2 genes RL1 and/or LAT might be involved in the virulence mechanisms in mouse infections.
The additive effect of biochar amendment and simulated nitrogen deposition stimulates the plant height, photosynthesis and accumulation of NPK in pecan (Carya illinoinensis) seedlings

Abstract This work investigated the effective doses of biochar (BC) amendment with simulated nitrogen deposition on the stimulation of pecan (Carya illinoinensis) growth. A total of nine conditions combining three levels of BC—BC0, 0 t ha−1 year−1; BC20, 20 t ha−1 year−1; and BC40, 40 t ha−1 year−1—and three levels of simulated nitrogen deposition—N0, 0 kg N ha−1 year−1; N50, 50 kg N ha−1 year−1; and N150, 150 kg N ha−1 year−1—were applied throughout 1 year on the pecan-grafted seedlings of cultivar ‘Pawnee’. The growth, photosynthesis, chlorophyll and nutrient content in the seedlings were measured. The soil bulk density, pH, nitrogen content and enzymatic activities were also measured. Biochar amendment reduced soil bulk density and elevated soil pH. Meanwhile, aided by BC amendment, the inorganic nitrogen content and enzyme activities increased with increasing doses of nitrogen. In the absence of BC amendment, the seedlings’ height, photosynthesis and chlorophyll pigments were only stimulated by a low level of simulated nitrogen deposition (N50), whereas a high level of simulated nitrogen deposition (N150) impeded the growth. The seedlings improved the most under the combined treatment of BC20N150, wherein the seedling heights, photosynthesis and total chlorophyll improved by 22 %, 70 % and 40 %, respectively, compared to those treated solely with BC20. Further increase of nitrogen retention in the soil by the BC40 did not further improve the growth of the seedlings, suggesting the possible mechanisms involve nutrient uptake and usage dynamic in the seedlings. The BC amendment alleviated the antagonist effect from simulated nitrogen deposition that suppressed the absorption of phosphorus, potassium and iron. The effect of applying both BC amendment and simulated nitrogen deposition to the growth of seedlings was additive at fertilizing tree species.
Truck Drivers’ Cigarette Smoking and Preferred Smoking Cessation Methods

Introduction: Some studies show that truck drivers use tobacco and other stimulants to stay awake as they drive. Despite their increased risks for many of tobacco-related health disparities, there is limited engagement of truck drivers in smoking cessation programs. The objective of this study was to describe smoking characteristics and identify their preferred smoking cessation methods among truck drivers. Methods: This was a cross-sectional mixed methods study. Participants were truck drivers recruited at trucking companies in Utah in 2019. Participants were either individually interviewed (n = 4), or filled out a survey (n = 33). We conducted qualitative data analysis of the interviews followed by descriptive statistics of smoking and cessation characteristics from the survey. Results: Reasons for smoking included, staying awake, stress reduction, or something to do while driving. Of the drivers surveyed, 68.8% were daily smokers while 97% had smoked at least 100 cigarettes in their life time. The mean number of cigarettes per day (cpd) was 15.7, and 25 among those who had 10 or more cpd. Sixty-one percent had made at least a quit attempt. In addition to counseling or brief advice, 68% reported interest in using Nicotine Replacement Therapy (NRT) either as gum or patch to help them quit. 21% reported interest in telephone text messaging to engage them in treatment. Conclusion: Cigarette smoking is a public health problem among truck drivers. Our findings suggest that truck drivers are interested in quitting smoking. Evidence based interventions tailored to this population are needed to help them quit and reduce their smoking-related morbidity.
A Brain-Inspired Adaptive Space Representation Model Based on Grid Cells and Place Cells

Grid cells and place cells are important neurons in the animal brain. The information transmission between them provides the basis for the spatial representation and navigation of animals and also provides reference for the research on the autonomous navigation mechanism of intelligent agents. Grid cells are important information source of place cells. The supervised learning and unsupervised learning models can be used to simulate the generation of place cells from grid cell inputs. However, the existing models preset the firing characteristics of grid cell. In this paper, we propose a united generation model of grid cells and place cells. First, the visual place cells with nonuniform distribution generate the visual grid cells with regional firing field through feedforward network. Second, the visual grid cells and the self-motion information generate the united grid cells whose firing fields extend to the whole space through genetic algorithm. Finally, the visual place cells and the united grid cells generate the united place cells with uniform distribution through supervised fuzzy adaptive resonance theory (ART) network. Simulation results show that this model has stronger environmental adaptability and can provide reference for the research on spatial representation model and brain-inspired navigation mechanism of intelligent agents under the condition of nonuniform environmental information.
The gut: the 'motor' of multiple organ dysfunction syndrome?

: Abnormal colonization, gut-origin infections, and bacterial translocation are all signs of gut dysfunction that may be implicated in the pathogenesis of multiple organ dysfunction syndrome (MODS). This review summarizes and updates relevant experimental and clinical data that have attempted to correlate these phenomena with the development of MODS and to answer whether or not the gut is the 'motor' of MODS. The presented data suggest that, in some patients, gut dysfunction may precede the development of MODS. However, in most patients, this relationship is less obvious. The gut may still be one of the motors of MODS; however, it does not appear that this motor is fueled by the systemic spread of bacteria. Bacteria may play a role on a local gut-associated level in initiating and perpetuating the production of local inflammatory mediators that may produce distant organ injury.
Analytical Model for Vadose Zone Solute Transport with Root Water and Solute Uptake

An efficient method is presented for calculating one‐dimensional solute transport through the vadose zone in the presence of vertically distributed root water and solute uptake. The method is based on an analytical solution of the convective transport equation, which is solved by the method of characteristics. The solution requires a time‐invariant leaching fraction, and assumes that transport occurs by convection alone; that is, hydrodynamic dispersion and molecular diffusion are neglected. From this solution, two variables of practical importance are calculated, (i) the average solute concentration in the root zone, weighted by the root distribution, and (ii) the cumulative solute flux to the groundwater. Model parameters are related to water management, crop type, and soil type, through the following parameters: leaching fraction, root distribution, and soil hydraulic properties. Simulation results are presented for both downward and upward flow scenarios. Simulations with a nonuniform moisture profile indicate that nearly identical results are obtained by replacing the profile by a uniform moisture content equal to the arithmetic average or the uptake‐weighted average moisture content, so that closed‐form analytical expressions for travel time and travel depth can be obtained. A sensitivity analysis of the relevant model parameters shows that solute concentrations are largely determined by the magnitude of the effective water application ratio, defined by the fraction of infiltrated water that is removed by evapotranspiration. We present suggestions of how dispersive mixing and temporal changes in leaching fraction are readily incorporated into the current model. Although potentially simplistic, the presented methodology can be extremely useful for longer‐term and field‐to‐regional scale characterization of contaminant movement.
CORPORATE SUSTAINABILITY: Accountability and the Pursuit of the Impossible Dream

Corporations are, at the risk of over-simplification, the engines of the economy. They are the key means through which economic activity takes place (and, under the neo-liberal agenda, will increasingly be so). Corporations are so often the seat of innovation through which growth is sought and, apparently, achieved. They are, indubitably, the site of increasing economic and political power, (see, for example, Korten, 1995). It seems incontrovertible that, in the absence of a fundamental change in the political will of governments (especially those of the developed world), any serious examination of sustainability and how it might be achieved must have the corporation at its heart. (For more detail, see, for example, Hawken et al, 1999; Gladwin et al, 1995; Kovel, 2002)