Miracle-dz/UniFAR-FTUs huggingface dataset:
DMSO_A_202193 1527..1541

Department of Metabolism & Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, People’s Republic of China; Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, Changsha, People’s Republic of China; National Clinical Research Center for Metabolic Diseases, Changsha, People’s Republic of China; Hunan Key Laboratory for Metabolic Bone Diseases, Changsha, People’s Republic of China; Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, People’s Republic of China; Department of Endocrinology, Heji Hospital Affiliated to Changzhi Medical College, Changzhi, People’s Republic of China; Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, People’s Republic of China; Department of Endocrinology, Xijing Hospital, Fourth Military Medical University, Xi'an, People’s Republic of China; Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China Aim: This study aimed to estimate the prevalence of latent autoimmune diabetes of adults (LADA) and classic type 1 diabetes mellitus (T1DM) in newly diagnosed adult diabetes in China. Method: This cross-sectional study involved 17,349 newly diagnosed diabetes in adults aged ≥30 years from 46 hospitals within 31 months. Demographic characteristics, clinical features, and medical history were collected by trained researchers. T1DM as a whole was comprised of classic T1DM and LADA. Classic T1DM was identified based on the clinical phenotype of insulin-dependency, and LADA was differentiated from patients with initially an undefined diabetes type with standardized glutamic acid decarboxylase autoantibody testing at the core laboratory. The age and sex distributions from a large national survey of diabetes in China conducted in 2010 were used to standardize the prevalence of classic T1DM and LADA. Results: Among 17,349 adult patients, the prevalence of T1DM was 5.49% (95% CI: 4.90– 6.08%) (5.14% [95% CI: 4.36–5.92%] in males and 6.16% [95% CI: 5.30–7.02%] in females), with 65% of these having LADA. The prevalence of classic T1DM decreased with increasing age (p<0.05), while that of LADAwas stable (p>0.05). The prevalence of T1DM in overweight or obese patients was 3.42% (95% CI: 3.20–3.64%) and 2.42% (95% CI: 1.83–3.01%), respectively, and LADA accounted for 76.5% and 79.2% in these two groups. Conclusion: We draw the conclusion that T1DM, especially LADA, was prevalent in newly diagnosed adult-onset diabetes in China, which highlights the importance of routine islet autoantibodies testing in clinical practice.
Does strength training improve musculoskeletal health and body composition in black men with prostate cancer on androgen deprivation therapy

Title of Document: DOES STRENGTH TRAINING IMPROVE MUSCULOSKELETAL HEALTH AND BODY COMPOSITION IN BLACK MEN WITH PROSTATE CANCER ON ANDROGEN DEPRIVATION THERAPY? Erik Daniel Hanson, PhD, 2011 Directed By: Professor Ben Hurley, Department of Kinesiology Prostate cancer (PCa) is the most commonly diagnosed cancer in U.S. men and disproportionately affects black men more than any other racial or ethnic group. Despite this disparity, black men have been underrepresented in previous studies. PCa is commonly treated using androgen deprivation therapy (ADT). However, ADT induces numerous adverse side effects, including loss of muscle mass, strength, power, and physical function with concomitant increases in fat mass, fatigue, and bone fractures. Because strength training (ST) can reverse these factors in healthy older adults, it was hypothesized that ST would be effective in PCa patients on ADT but with an attenuated response. Therefore, the purpose of this study was 1) to examine the effects of ST on musculoskeletal and body composition side effects in black men on ADT, 2) to compare ST responses of black PCa patients on ADT to those of black healthy reference controls, and 3) to determine if changes in musculoskeletal health and body composition with ST are associated with changes in fatigue, physical function, and quality of life (QoL). PCa patients (N=17) completed a 12 week ST program, which produced many beneficial effects on factors adversely affected by ADT, including substantial gains in muscle power, size, strength, and endurance (all P < 0.001), resulting in a more favorable body composition (P < 0.001) and increased physical function (all P < 0.05). ST also improved fatigue perception and QoL (both P < 0.05). Compared with healthy reference controls (N=20), PCa patients responded to ST with similar gains in muscle power, strength, and mass, which was contrary to expectations. However, PCa patients had higher fat mass and lower muscle power and strength than controls at baseline (all P < 0.05). Finally, the changes in physical function, fatigue perception, and QoL were associated with some of the changes in muscle function with training. The findings in this study provide support for the hypothesis that ST improves musculoskeletal health and body composition in black men with PCa on ADT by demonstrating significant improvements in muscle power, mass, strength, and endurance, which can enhance physical function and QoL. DOES STRENGTH TRAINING IMPROVE MUSCULOSKELETAL HEALTH AND BODY COMPOSITION IN BLACK MEN WITH PROSTATE CANCER ON ANDROGEN DEPRIVATION THERAPY?
Laparoscopic repair of umbilical and paraumbilical hernias: a prospective and interventional study in government hospital

Background: Umbilical and ventral hernia occurs as a result of weakness in musculofascial layer of anterior abdominal wall. The most important causes are congenital, acquired, incisional and traumatic. UH and VH can be repair by open surgical procedure. A successful series of laparoscopic repair of umbilical hernia and VH was done by Le blanc in 1993. The cost can be optimised by selection of mesh and optimal uses of transabdominal suture and various fixation devices. This original article reveals methods, techniques, indication, contraindication, post-op pain, operative time, surgical site infection recurrence and outcome of laparoscopic umbilical hernia and paraumbilical hernia repair.Methods: A total of 21 patients of ventral hernia (umbilical, paraumbilical and incisional), who underwent laparoscopic hernia repair from October 2014 to October 2016, were selected have taken part in study with valid consent, in B.J. Medical College Ahmedabad Gujarat. All patient study regarding operative time, postoperative pain, postoperative hospital stay, surgical site infection like wound infection, seroma, hernia defect size, mean drain removal and recurrence.Results: Out of 21 patients male are 33% and female are 67%. Mean age of patients is 45 yrs with range being 18-65 yrs. 28%, 33.33%, and 38.1% of patient had umbilical, paraumbilical and incisional hernia respectively. Mean size defect was 7.8 cm2. Mean operative time in this study is 98.6 minute. Mean drain removal is 2.80 day. Mean postoperative hospital stay was 3.3 days. 4.7% had wound infection, 9.5% had seroma formation. There is 0% recurrence in present study.Conclusions: The laparoscopic approach appears to be safe, effective and acceptable. It is also effective in those who are obese, with co morbidities (complex) and who have recurrence from prior open repair and having ascites.
The use of body-worn cameras in pre-hospital resuscitation

Introduction: Body-worn cameras (BWCs) are commonplace in many workplaces, but rare in the real-time audit of clinical performance in the pre-hospital setting. There are currently no data supporting the use of BWCs as an acceptable tool in clinical audit. Out-of-hospital cardiac arrest (OHCA) is a good candidate for audit – time critical, high stakes and not well observed. While the use of cameras to record such clinical data is demonstrably useful, it could be perceived by front line ambulance staff as intrusive and have a deleterious impact on clinical care. Investigating these potential barriers is important in ensuring that our effort to enhance the early phase of pre-hospital care through video audit does not have negative unintended consequences. Methods: Since 2012, the Resuscitation Research Group has used BWCs to provide a unique insight into how care is delivered by paramedics attending OHCAs. Paramedics attending arrests as part of the Resuscitation Rapid Response Unit (3RU) second-tier response wear a BWC, and collect real-time footage of these challenging, emotive clinical encounters. This footage has provided a unique medium for the audit of both individual technical task and team-oriented non-technical skills performance. We present the results of a survey in which paramedics share their views on the use of BWCs within their service. Results: A convenience sample of 83 questionnaires was collected. In relation to the primary outcome of the study, 81% (n = 53) of paramedics who responded to the statement, ‘the use of BWCs is a positive step for the service’, agreed or remained neutral, while only 19% (n = 12) disagreed. Conclusion: BWCs, and the supporting infrastructure and feedback processes, are an effective, acceptable and beneficial tool in the audit and analysis of team performance in pre-hospital resuscitation.
Investigating the nephrogenic potential of mouse embryonic stem cells and their derivatives

The kidneys are important organs that regulate the level of water and salts in the blood, produce hormones that help to control blood pressure, and maintain homeostasis of the organism by filtering waste products. Kidney disease can either be acute or chronic, the latter progressively worsening over time to become end stage renal disease (ESRD) – a stage when kidneys are non-functional. At present, the only treatment options for ESRD are transplantation or dialysis, which both have severe drawbacks in terms of morbidity, mortality and economic cost. Moreover, the incidence of ESRD is rising annually and an alternative therapy is needed. Therefore, in order to regenerate kidney tissue or prevent worsening of the kidney condition, a new therapy should be developed. One approach is to use embryonic stem cells.
Mechanical properties of experimental resin cements containing different photoinitiators and co-initiators

Aim The aim of this study was to evaluate the influence of different concentrations of two photoinitiators and one co-initiator on the flexural strength (FS) and elastic modulus (E) of experimental resin cements. Materials and methods A mixture containing BisGMA, TEGDMA, and barium-aluminum-silicate (BaAlSi) and silanized colloidal silica (SiO2) filler particles was prepared with two photoinitiators, viz. camphorquinone (CQ) and bisacylphosphine oxide (BAPO). Dimethylaminoethyl methacrylate (DMAEMA) was used as co-initiator. Thirty groups (n=10) were formulated with different photoinitiator systems (CQ/DMAEMA and BAPO/DMAEMA) and concentrations (wt%) of photoinitiator and co-initiator. The photoactivation was carried out for 20 s with a light-emitting diode (LED, Bluephase, Ivoclar Vivadent) with irradiance of 1200 mW/cm2. The FS and E were obtained in a three-point bending test on a universal testing machine (0.5 mm/min). Data were subjected to the Kolmogorov-Smirnov normality test, followed by two-way ANOVA and Tukey’s test (α=0.05). Results No polymerization occurred in the CQ groups without DMAEMA (0 wt%). DMAEMA 0.5 %wt and 1 %wt groups showed statistically similar FS and E results for CQ and BAPO, except for CQ 0.3 wt% (FS), CQ 0.9wt% (E) and BAPO 1.76 wt% (FS and E) for DMAEMA 0.5 %wt. No significant difference was found for FS and E values for different concentrations of photoinitiators, except for CQ 0.25 wt% (FS and E) and BAPO 0.25 wt% (E) that showed the lowest values. Conclusion The wt% of the photoinitiators and co-initiator influenced the mechanical properties and the performance of CQ was dependent on the DMAEMA concentration. BAPO can be used as substitute for the conventional CQ/DMAEMA photoinitiator system.
The role of Pontin in stress-induced cardiac hypertrophy

Cardiovascular disease (CVD) with end-stage heart failure is the leading cause of death globally with increasing prevalence in the aging populations. In response to pathological stress such as chronic hypertension, increased blood volume triggers heart enlargement to initially adapt to increased demand for cardiac performance. However, prolonged cardiac hypertrophy can trigger adverse modifications in the heart such as increased cardiac fibrosis, oxidative stress, cardiomyocyte death, cardiac arrhythmia and finally heart failure. The inhibition of pathological cardiac hypertrophy therefore presents as a promising therapeutic strategy to prevent heart failure progression. In the attempts of identifying therapeutic targets for heart failure management, several oncogenes have been recognised as the regulators of pathological cardiac hypertrophy. In this study, we hypothesised that Pontin, commonly known as an oncogene, was involved in regulating cardiac responses to hypertrophic stimuli. This study employed two mouse models i.e., Pontin global heterozygous knockout and cardiomyocyte-specific Pontin expression to investigate the possible in vivo functions of Pontin in regulating cardiac responses under chronic Angiotensin II infusion. Cardiac characterisation has revealed that the lack of Pontin was associated with increased cardiomyocyte death, oxidative stress and excessive autophagy in the heart during stress conditions. Meanwhile, Pontin overexpression could alleviate these adverse modifications in the heart under the same stimuli. Mechanistic analysis has shown that Pontin could regulate autophagy induction through the mTORC1 complex. The lack of Pontin or its ATPase activity could result in reduced mTORC1 function and subsequently increased autophagy induction in cardiomyocytes. Additionally, the findings from this study also indicated the adverse role of excessive cardiomyocyte autophagy in pathological cardiac hypertrophy. Therefore, the manipulation of cardiac autophagy downstream of Pontin or the mTORC1 complex could become a promising strategy to prevent pathological cardiac hypertrophy and possibly heart failure.
Atherosclerosis risk assessment in patients with chronic obstructive pulmonary disease: a case-control study

Purpose Chronic Obstructive Pulmonary Disease (COPD) is considered as a risk factor for atherosclerosis and a leading cause of mortality due to cardiovascular disease (CVD). The study assessed the association of COPD with atherosclerotic risk factors and compared the predictor role of various cardiovascular (CV) risk score calculators in Indian subjects with COPD. Patients and methods Forty subjects with stable COPD and forty age, gender and body mass index (BMI)-matched healthy controls were included in the case-control study conducted in a tertiary care hospital. Atherogenic indices were calculated by using the values of lipid parameters. CV risk calculators were utilized to assess the 10-year CV risk for the COPD group. Results The study subjects had a mean age of 60.83±12.40 years in COPD group and 57.73±9.49 years in control group (p=0.213). Gender distribution was similar in both the groups. The mean High sensitivity C-reactive protein (hs-CRP) levels were 3.70±2.37 mg/L in COPD group and 2.39±2.23 mg/L in control group. The hs-CRP levels were significantly higher in COPD than in control subjects (p=0.012). Using bivariate correlations, we found significant positive correlations between hs-CRP and atherogenesis indices-atherogenic index of plasma, cardiogenic risk ratio, atherogenic coefficient in COPD patients [(r=0.4265, p<0.006); (r=0.7034, p<0.001) and (r=0.7034, p<0.001), respectively]. Framingham risk score-cardiovascular disease (FRS-CVD) has identified maximum number of COPD subjects (45%) to be in high CVD risk category. Conclusion The study concluded that hs-CRP levels in COPD subjects were significantly higher than in control subjects. FRS-CVD was most useful for identifying high CV risk subjects in COPD subjects.
Low levels of HDL-cholesterol and peripheral artery disease: Protocol for systematic review and meta-analysis

Purpose of review: HDL-C is believed to retard the formation of atherosclerotic lesions by removing excess cholesterol from cells and preventing endothelial dysfunction. However, there are no systematic analyses or well-conducted meta-analyses to evaluate the relationship between very low HDL-Cand stroke. Patients with peripheral artery disease (PAD) have been found to suffer from diabetes, obesity, lipid abnormalities, including elevated levels of total and LDL-cholesterol as well as triglyceride levels. The aim of this study is to examine this association of very low HDL-Cwith stroke in different ages and sex. Recent findings: The update systematic review and meta-analysis will be conducted using published studies that will be identified from electronic databases (ie, PubMed, EMBASE, Web of Science, and Google Scholar. Studies that (1) examined the association between very low HDL-Cand stroke, (2) had a longitudinal or prospective cohort design, (3) will conducted among in adults aged 34 to 70 years. , (4) provided sufficient data for calculating odds ratios (ORs) or relative risk with a 95% CI, (5) were published as original articles written in English or other languages, and (6) have been published until January 2019 will be included. Study selection, data collection, quality assessment and statistical syntheses will be conducted based on discussions among investigators. Summary: Ethics approval was not required for this study because it was based on published studies. The results and findings of this study will be submitted and published in a scientific peer-reviewed journal. Strengths and limitations of this study: This systematic review and meta-analysis will offer better understanding regarding the association between metabolic syndrome and peripheral artery disease (PAD). The findings from this study will be useful for assessing of very low HDL-Cand the risk factors in PAD, and determining approaches for prevention of PAD the future. An improved understanding of this relationship may help to inform public health PAD prevention strategies. Included studies may have substantially different methodologies, which could limit our ability to draw reliable conclusions from the existing evidence base. Depending on the results, confounding factors that were not adjusted for the selected studies and low generalizability situations can be limitations. To minimize these limitations, we will evaluate the heterogeneity between the studies, perform sensitivity analysis and meta-regression. *Correspondence to: Leonardo Roever, Federal University of Uberlândia, Department of Clinical Research, Uberlândia, Brazil, E-mail: leonardoroever@hotmail.com
Enhancing Bodily Movements of the Visually Impaired Children by Airflow

A R T I C L E I N F O A B S T R A C T Article history: Received: 22 June, 2019 Accepted: 02 August, 2019 Online: 07 August, 2019 This study involved three departments of teachers and students. The concept of the flowmotivated exercise implemented with a set of flow nozzles. A computer-controlled airflow with specific music introduced, and the motion responses from the participants were analyzed during the initial test and field study. During the initial examination, we adjusted the magnitude and distance setting of the flow and allowed the children to grab the air without music. Structural design, magnetic valve, and interface were implemented based on the insights from the initial test. The redesign performed in a sitting position to reduce the need for students to deviate from the location and fit for physical disabilities during exercise. Four times of visually impaired students were arranged to observe the changes in the movements of students after being guided by the airflow during the teaching process. The performance of the fourth week is better than the previous three weeks. Almost all blind children can make movements in the right position. The cross-domain cooperation experience was beneficial to the facility design.
Results of ten years aorto-coronary bypass surgery at the Thoraxcenter, Rotterdam

textabstractThe aim of this thesis is the description of the outcome of isolated aortacoronary bypass operations, both regarding the short term effects i.e. the operative mortality as well as the Long term results i.e. the general wellbeing and survival probability of the patients over the years. The main indication for this type of surgery is and always has been, persisting angina pectoris despite extensive pharmacological therapy. The outcome of surgery therefore, should be judged, among other things, by the presence and severity of this syndrome in the post-operative period. To place these data in perspective, a review of the Literature on surgical therapy of angina is provided in chapter 2. As discussed in chapter 3, it has become apparent over the years that the perception of the severity of angina pectoris is changeable and very difficult to quantify. Still an attempt has been made, to analyse the data on this complaint, although it is realised that it is fraught with errors as simplifications are required when Large numbers are to be judged. Improved survival has by now become an important issue to justify bypass surgery. A multivariate analysis of the factors which influence survival is provided in chapter 4. For comparison, the survival probability of the general population in the Netherlands, matched for age and sex, has been related to the data of the patients under study. In chapter 5 the evolution in post-operative chest pain is documented, while the results of re-operations of patients who underwent their primary operation at the Thoraxcenter, are discussed in chapter 6. In chapter 7 a correlation is sought between the presence of pain in the chest and the extent of vascular involvement in the pre- and postoperative angiograms. Patency of the grafts and progression of disease in relation to post-operative pain is discussed as well in these chapters. Chapter 8 contains a general but critical discussion of bypass surgery in an attempt to view, from all angles, the relative merits and disadvantages of this currently so popular procedure. This study would not have been possible without the generous help of our patients. First by their part in the design of the questionnaire and Later by their responding to it in such Large numbers. To emphasize that this material ultimately relates to the specific problem of the individual patient, the histories of 4 patients are represented in a detailed but compressed form. Their stories reflect, better perhaps than statistics, what it means to have a "BYPASS OPERATION"
Total Artificial Heart: A Retrospective Descriptive Analysis of Functional Improvement Associated With Postsurgical Rehabilitation

Medical Device Notice: This original research includes the presence of the SynCardia Total Artificial Heart device (SynCardia Systems, LLC). The 700-mL temporary total artificial heart and CardioWest driver gained approval from the US Food and Drug Administration (FDA) on October 15, 2004, for indicated use as a bridge to transplant device in cardiac transplant–eligible candidates at risk for imminent death from biventricular failure. This device also received FDA approval for the Humanitarian Use Device designation, to be used for destination therapy. The associated drivers were approved by the FDA on July 5, 2012, for the Companion 2 driver and on June 26, 2014, for the Freedom portable driver. During this study, the Freedom portable driver was an investigational use. Mayo Clinic does not endorse specific products or services included in this article. IRB number: 14-006669.