Miracle-dz/UniFAR-FTUs huggingface dataset:
Socio-demographic characteristics associated with emotional and social loneliness among older adults in �ve European countries

Background: International studies provide an overview of socio-demographic characteristics associated with loneliness among older adults, but few studies distinguished between emotional and social loneliness. This study examined socio-demographic characteristics associated with emotional and social loneliness. Methods: Data of 2251 community-dwelling older adults, included at the baseline measure of the Urban Health Centers Europe (UHCE) project, were analysed. Loneliness was measured with the 6-item De Jong-Gierveld Loneliness Scale. Multivariable logistic regression models were used to evaluate associations between age, sex, living situation, educational level, migration background, and loneliness. Results: The mean age of participants was 79.7 years (SD=5.6 years); 60.4% women. Emotional and social loneliness were reported by 29.2% and 26.7% of the participants; 13.6% experienced emotional and social loneliness simultaneously Older age (OR: 1.16, 95% CI: 1.06-1.28), living without a partner (2.16, 95% CI: 1.73-2.70), and having a low educational level (OR: 1.82, 95% CI: 1.21-2.73), were associated with increased emotional loneliness. Women living with a partner were more prone to emotional loneliness than men living with a partner (OR: 1.78, 95% CI: 1.31-2.40). Older age (OR: 1.11, 95% CI: 1.00-1.22) and having a low educational level (OR: 1.77, 95% CI: 1.14-2.74) were associated with increased social loneliness. Men living without a partner were more prone to social loneliness than men living with a partner (OR: 1.94, 95% CI: 1.35-2.78). Conclusions: Socio-demographic characteristics associated with emotional and social loneliness differed regarding sex and living situation. Researchers, policy makers, and healthcare professionals should be aware that emotional and social older with different socio-demographic characteristics.
RMHP_A_274340 2115..2123

1Department of Neurology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, People’s Republic of China; 2Department of Neurology, The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China; 3Department of Neurology, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 4Department of Ultrasonography, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, People’s Republic of China; 5Department of Center for Clinical Epidemiology and Methodology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, People’s Republic of China; 6Department of Neurology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, People’s Republic of China; 7Center for Precision Medicine and Division of Cardiovascular Medicine, Department of Medicine, University of Missouri School of Medicine, Columbia, MO, USA
WEAKLY PRIMES AND RELATED SIEVE FORMULATIONS

A prime number p is called a weakly prime in base b if when any single digit of the base b expansion of b is switched to any other digit 0 , . , b − 1 , the resulting number is composite. Tao [13] proved that for any ﬁxed base b, a positive proportion of primes are weakly in base b. In this paper, we investigate the exact proportion of such primes for a given base b , and how the values of b and φ ( b ) aﬀect this proportion. We provide two possible sieve formulations for this proportion. We also prove several propositions regarding weakly primes across bases and examine weakly primes in small prime bases. We also include an algorithm for generating weakly primes with constant space complexity, and numerical data generated by this algorithm.
Extracellular Ca Ameliorates NaCl-Induced K Loss from Arabidopsis Root and Leaf Cells by Controlling Plasma Membrane K-Permeable Channels

School of Agricultural Sciences (S.S., L.S., T.A.C.) and School of Mathematics and Physics (I.A.N.), University of Tasmania, Hobart, Tasmania 7001, Australia; Department of Biological Sciences, University of Essex, Essex CO4 3SQ, United Kingdom (V.D.); Crop Performance and Improvement Division, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, United Kingdom (S.J.S., A.J.M.); and Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, United Kingdom (J.M.D.)
Evaluation of Anthelmintic, Analgesic and Neuropharmacological Activity of the Plant Abutilon Indicum

The present investigation was conducted to determine the anthelmintic, analgesic and neuropharmacological activity of the methanolic extract from the barks of Abutilon indicum. Anthelmintic activity was investigated using earthworm (Pheretima posthuma) and fresh leaf juice of the plant. In anthelmintic activity test, the time of paralysis for leaves juice was range from 25min 37 sec to 65min 12 sec whereas the time ranges for standard drug albendazole was 31 min 57 sec to 75min 27 sec. On the other hand the time of death start from 31 min 43 sec and end to 72 min 09 sec for leaves juice and for albendazole the time of death start from 39 min 22 sec and end 84 min 19 sec respectively at different dose (5mg/ml, 10mg/ml, 20mg/ml, 50mg/ml, 100mg/ml) which indicate highly significant anthelmintic activity. Analgesic activity was investigated using two thermal (hot plate and tail immersion) and one chemical (acetic acid-induced writhing test) methods at the dose of 200 and 400 mg /kg in Swiss albino mice. In analgesic activity test, the latency time of thermal threshold was prolonged in hot plate and tail immersion tests, whereas it was inhibited by acetic acid-induced writhing test. Thus the extract of the Abutilon indicum barks showed moderate analgesic activity. Neuropharmacological activity of the plant was observed by open field, hole cross, and dark/light box tests at the doses of 200mg/kg and 400 mg /kg in Swiss albino mice. The extract significantly decrease the locomotor activity as shown by the open field, hole cross test which indicate highly significant antidepressant activity. The results also showed similar activity in dark/light box test. Thus the obtained results in the study provide a support for the use of this plant for medicinal purposes and encourage further investigations for more fruitful results.
ELVIS study group (2019). Assessment of Brain Injury and Brain Volumes after Posthemorrhagic Ventricular Dilatation: A Nested Substudy of the Randomized Controlled ELVIS Trial. Journal of Pediatrics, 208, 191-197.e2.

Background: There is accumulating evidence showing beneficial effects of early intervention on posthemorrhagic ventricular dilatation (PHVD) and neurologic outcomes. Objective: To compare the effect of early and late intervention for PHVD on brain injury and ventricular volume using term-equivalent age magnetic resonance imaging (TEA-MRI). Methods: In the ELVIS (Early versus Late Ventricular Intervention Study) trial 126 preterm infants ≤34 weeks gestation with PHVD after grade III-IV intraventricular hemorrhage were randomised to low threshold (LT, ventricular index (VI) > p97 and anterior horn width (AHW) > 6mm) or higher threshold (HT, VI > p97 + 4mm and AHW > 10mm). The Kidokoro Global Brain Abnormality Score and the frontal and occipital horn (FOH) ratio were measured. Automatic segmentation was used to perform volumetric measurements. Results: Of the 110 surviving infants, TEA-MRI was obtained in 88 (80%) infants, of which 44 were in the LT group and 44 in the HT group. The total Kidokoro score of the infants in the LT group was lower than in the HT group (median (interquartile range): 8 (5-12) vs 12 (9-17), respectively; p<0.001). When the groups were compared in terms of severity of the Kidokoro score, there were more infants in the LT group with a normal or mildly increased score, and more infants in the HT group with a moderately or severely increased score (46% vs. 11% and 89% vs. 54%, respectively; p=0.002). The FOH ratio was lower in the LT group, when compared with the HT group (0.42 (0.34-0.63) vs 0.48 (0.37-0.68), respectively; p=0.001). The ventricular CSF volumes were calculated in 47 infants and were smaller in the LT group (p=0.03). Conclusion: Our findings demonstrate more brain injury and larger ventricular CSF volumes in the HT group. These results contribute to the growing evidence for the positive effects of early intervention for PHVD.
SYNCHROTRON RADIATION OF SELF-COLLIMATING RELATIVISTIC MAGNETOHYDRODYNAMIC JETS

The goal of this paper is to derive signatures of synchrotron radiation from state-of-the-art simulation models of collimating relativistic magnetohydrodynamic (MHD) jets featuring a large-scale helical magnetic field. We perform axisymmetric special relativistic MHD simulations of the jet acceleration region using the PLUTO code. The computational domain extends from the slow-magnetosonic launching surface of the disk up to 60002 Schwarzschild radii allowing jets to reach highly relativistic Lorentz factors. The Poynting-dominated disk wind develops into a jet with Lorentz factors of Γ ≃ 8 and is collimated to 1°. In addition to the disk jet, we evolve a thermally driven spine jet emanating from a hypothetical black hole corona. Solving the linearly polarized synchrotron radiation transport within the jet, we derive very long baseline interferometry radio and (sub-) millimeter diagnostics such as core shift, polarization structure, intensity maps, spectra, and Faraday rotation measure (RM) directly from the Stokes parameters. We also investigate depolarization and the detectability of a λ2-law RM depending on beam resolution and observing frequency. We find non-monotonic intrinsic RM profiles that could be detected at a resolution of 100 Schwarzschild radii. In our collimating jet geometry, the strict bimodality in the polarization direction (as predicted by Pariev et al.) can be circumvented. Due to relativistic aberration, asymmetries in the polarization vectors across the jet can hint at the spin direction of the central engine.
CLASSICAL STATISTICAL MECHANICS OF A SYSTEM OF PARTICLES

The free energy of a system of particies interacting by a two-body potential was investigated for the canonical ensemble The existence of a limit for the free energy per particle when the system becomes infinite and the stability conditions were proved rigorously for a large class of potentials. It was also shown that the pressure is a continuous function of the volume for bounded potentials. The grand canonical ensemble was investigated in a similar manner and a generaiization of the resuits of Yang and Lee is given. (auth)
Impact of digital time delay on the stable grid-hosting capacity of large-scale centralised PV plant

Correspondence Jinhong Liu, School of Automation, Nanjing University of Science and Technology, Xiaolingwei Road, Nanjing, China. E-mail: jinhongliu.felix@gmail.com Abstract Digital control system has been widely used for the inverters in PV plant. However, the effects of digital time delay of digital control system on grid-connected PV plants have not been fully studied. Therefore, in view of the stable grid-hosting capacity is a key parameter in the process of designing and operating of a grid-connected PV plant, this paper investigates in detail the influence of digital time delay on the stable grid-hosting capacity of large-scale centralised PV plant. Considering the practical situation of large-scale centralised PV plants, the stable grid-hosting capacity of plant is discussed with the conditions of inverters in PV plant have the same and different digital time delays. The analysis results revealed that stable grid-hosting capacity is varied with the digital time delay of inverter and the combination of the inverter with different digital time delays. Meanwhile, in order to realize a stable grid-connected PV plant in particular delay case, a procedure on how to determine the exact inverter number that can be used in a specific PV plant is provided. The theoretical analysis is verified by simulation and equivalent experiment results.
GI-530159, a novel, selective, mechano-sensitive K2P channel opener, reduces rat dorsal root ganglion (DRG) neuron excitability.

TREK two pore domain potassium channels play a critical role in regulating the excitability of somatosensory nociceptive neurons and are important mediators of pain perception. An understanding of the roles of TREK channels in pain perception and, indeed, in other pathophysiological conditions, has been severely hampered by the lack of potent and/or selective activators and inhibitors. In this study we describe a new, selective opener of TREK channels, GI-530159 ( 4,4(cid:397) -(Hexafluoroisopropylidene)bis(p-phenyleneoxy)dianiline). The effect of GI-530159 on TREK channels was demonstrated using 86 Rb efflux assays, whole-cell and single channel patch clamp recordings from recombinant TREK channels. TREK1, TREK2 and TRAAK expression was determined using transcriptome analysis from single dorsal root ganglion (DRG) cells. Current-clamp recordings from cultured rat DRG neurons were used to measure the effect of GI-530159 on neuronal excitability.
A Research on the Determination of Consumer Perceptions Related to Guerrilla Marketing Methods: Sample of Izmir Province

In developing technology and differentiating markets, businesses have resorted the way of increasing their competitiveness by taking advantage of new marketing methods in order to stand out in the market. Within this context, companies have started to use different marketing strategies in order to be more effective in the market and to maintain their presence and awareness in different ways. Guerrilla marketing is an important marketing technique that small and medium-sized businesses are using with minimum marketing investments in extraordinary ways at unexpected times to attract attention of the target audience in today's increasingly competitive environment. This study focuses on guerrilla marketing which is an important marketing technique that small and medium-sized enterprises (SMEs) have applied, using unusual methods, in unexpected times, with minimum marketing investments to attract the attention of target audience in today's increasingly competitive environment. In order to determine the consumer perception about guerrilla marketing methods, a survey was applied to 384 people living in Izmir. Factor analysis was applied to the obtained survey data in SPSS 22 statistics program. Three results were obtained. 'Extraordinary' has been identified as the most important factor. The second important factor is 'Interesting and surprising', and the final factor is 'Communication'. Kolmogorov Smirnov test was conducted to determine which tests should be performed on the sub-dimensions of the scale of Consumer Perception on Guerrilla Marketing Methods (SCPGMM). It was determined that the distribution was not normal and Kruskal Wallis and Mann Whitney U tests were applied to the sub-dimensions of SCPGMM. According to the test results, It has been determined that the "Extraordinary" (F1) sub-dimension of the SCPGMM sub-dimensions varies according to gender, age, education and marital status; the "interesting and surprising" (F2) sub-dimension varies according to the education and the "Communication" (F3) sub-dimension varies according to gender and marital status.
Rational reduction of reactive flow models and efficient computation of their solutions

by Sandeep Singh This study will focus on the development of methods for rational reduction of model equations of reactive systems and their efficient numerical simulations. The method of Intrinsic Low-Dimensional Manifold (ILDM), which is used to obtain reduced model equations for spatially homogeneous reactive systems modeled by a system of stiff ordinary differential equation (ODEs), is described in detail. A less stiff reduced system of ODEs is obtained using the ILDM method by equilibrating the fast time scale chemical processes and resolving only the slow time scale chemical processes. The accuracy of the standard ILDM approximation is clarified, and it is shown that the ILDM is a good approximation of the Slow Invariant Manifold (SIM) for stiff ODEs and small manifold curvature. Efficient construction of multidimensional ILDMs in a polar parametric space is also presented. Subsequently, an operator splitting method is used to extend the use of the ILDM method to spatially inhomogeneous reactive systems or reactive flow systems modeled by a system of partial differential equations (PDEs). This procedure is implemented on a onedimensional viscous detonation problem for a mixture of hydrogen-oxygen-argon in a shocktube. The operator splitting method allows each spatial point to be treated as a spatially homogeneous premixed reactor in the reaction step, so that the ILDM method can be implemented. The Wavelet Adaptive Multilevel Representation
The Comma

5. Around nonrestrictive (nonessential) words or phrases Flannery O’Connor, a Southern writer, has much in common with William Faulkner. She had hoped, of course, to marry Homer Barron. Eric, the first in his family to graduate college, walked proudly across the stage. Dr. Smith, a respected dentist, donates five hours a week to the free medical clinic. Many people, as Dr. Stanley points out, are afraid of showing love and affection.
The effect of bilayer domains on electronic transport properties of epitaxial graphene on SiC

Magnetotransport measurements on Hall bar devices fabricated on purely monolayer epitaxial graphene on Silicon Carbide (SiC/G) show a very tight spread in carrier concentration and mobility across wafer- size dimensions. In contrast, SiC/G devices containing bilayer graphene domains display variations in their electronic properties linked to the amount of bilayer content.
Visualizing Probability of Detection to Aid Sonar Operator Performance

This study tested whether the display of rings indicating the probability of target detection would improve human performance on a simulated active sonar detection task. Participants viewed a series of simulated sonar returns and decided whether a target was present or not. Participants performed the task both with and without uncertainty range rings that indicated 90% and 10% detectability ranges. The probability of detection rings did not improve the overall ability of participants to distinguish targets from noise, but did appear to influence response bias and spatial attention. These results suggest that displaying probability of detection may not be an effective way of improving the performance of sonar system operators.
A DIFUSÃO DO CONHECIMENTO AGROECOLÓGICO NO BRASIL A PARTIR DA IDENTIFICAÇÃO DA PROCEDÊNCIA DOS PARTICIPANTES DE EVENTOS CIENTÍFICOS

O Congresso Brasileiro de Agroecologia promove debates que permitem traçar um panorama atual e desenvolver a temática agroecológica no país. Entretanto, pouco se conhece sobre a distribuição dos trabalhos científicos apresentados pelos participantes neste evento, em questão de procedência geográfica e afiliação. O objetivo deste estudo é identificar a partir dos anais de estudos apresentados nos últimos três eventos (em 2015, 2017 e 2019), as localidades e afiliações predominantes dos autores. Nos eventos realizados nos anos de 2015 e 2017 foram apresentados o menor e o maior número de trabalhos científicos, respectivamente. Os estados e regiões sede, de cada um dos eventos, tiveram crescimento no número de estudos em relação aos demais anos. A afiliação às universidades públicas apresentou maior ocorrência nos três eventos. Identificamos que a realização itinerante dos eventos possui alta importância para atração de diferentes participantes, sendo também essencial a realização em locais onde a participação mostrou-se pequena.
EL ROL DEL ALGORITMO DE ENTRENAMIENTO EN LA SELECCIÓN DE MODELOS DE REDES NEURONALES

The Neural net’s fit ability is often affected by the network configuration, particularly the number of hidden neurons and input variables. As the size of these parameters increases, the learning also increases, then the fit of network is better. Theoretically, if parameters are increasing regularly, the error should be reduced systematically, provided that the models are nested for each step of the process. In this work, we validated the hypothesis that the addition of hidden neurons in nested models lead to systematic reductions in error, regardless of the learning algorithm used; to illustrate the discussion we used the number of airline passengers and sunspots in Box & Jenkins, and RProp and Delta Rule as learning methods. Experimental evidence shows that the evaluated training methods show different behaviors as those theoretically expected, it means, not fulfilling the assumption of error reduction.
Myosin IXb by the Rho-GTPase Activating Protein Signaling Requires Regulation of Rho-Cofilin Dendritic Cell Motility and T Cell Activation

Directed migration of stimulated dendritic cells (DCs) to secondary lymphoid organs and their interaction with Ag-speciﬁc T cells is a prerequisite for the induction of primary immune responses. In this article, we show that murine DCs that lack myosin IXB (Myo9b), a motorized negative regulator of RhoA signaling, exhibit increased Rho signaling activity and downstream acto-myosin contractility, and inactivation of the Rho target protein coﬁlin, an actin-depolymerizing factor. On a functional level, Myo9b 2 / 2 DCs showed impaired directed migratory activity both in vitro and in vivo. Moreover, despite unaltered Ag presentation and costimulatory capabilities, Myo9b 2 / 2 DCs were poor T cell stimulators in vitro in a three-dimensional collagen matrix and in vivo, associated with altered DC–T cell contact dynamics and T cell polarization. Accordingly, Myo9b 2 / 2 mice showed an attenuated ear-swelling response in a model of contact hypersensitivity. The impaired migratory and T cell stimulatory capacity of Myo9b 2 / 2 DCs was restored in large part by pharmacological activation of coﬁlin. Taken together, these results identify Myo9b as a negative key regulator of the Rho/RhoA effector Rho-kinase [Rho-associated coiled-coil–forming kinase (ROCK)]/LIM domain kinase signaling pathway in DCs, which controls coﬁlin inactivation and myosin II activation and, therefore may control, in part, the induction of adaptive immune responses. The Journal of Immunology , 2014, 192:
Fostering Innovative Work Behaviour in SMEs Exploring Ecopreneurship Perspective

The research analyzes the mediational impact of creative self-efficacy through which Ecopreneurship impacts the behaviors of employees at work. The discretion behind the research is founded on using Bandura's social learning theory and a mediation model is presented to show the innovative effects of Ecopreneurship on employees’ Innovative Work Behavior (IWB) through the mediation of creative self-efficacy (CSE). The present research focuses on Innovation by developing a model that seeks to investigate the association among Ecopreneurship and Innovation Work Behavior in industrial SMEs of Pakistan for promoting the economic strength of the country. A framework has been developed comprising Creative Self-Efficacy as input. It is believed that unless SMEs emphasize Innovative Work Behavior, it is difficult to compete efficiently and gain higher economic returns. The nature of SME organizations is very dynamic, thus, particularly need to be innovative & creative to lead, nurture and compete in the industry. A questionnaire method has been used to collect the data; the unit of analysis is permanent workers from the industrial setups of SMEs in Pakistan. SPSS and AMOS have been used to analyze the data. The outcomes of the results show that Ecopreneurship stimuli Innovative Work Behavior via the mediation of CSE.