Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of hanging load on induction machine torque and stator current in hoisting winch system

The aim of this paper is to analyze theoretically and experimentally the stator current and the load torque of a three-phase induction machine in a hoisting winch system in order to show the influence of hanging load at different levels in motoring modes. In this paper, the results of hanging load are verified in time and time-frequency domains and it has been observed that in case of fast changing of the load, it introduces a non-stationary oscillation during a short time. This leads producing a low frequency component in both the output torque and the stator current spectrograms with different levels of hanging load.
A Model of Self-motion Estimation Primate Extrastriate Visual Cortex

Perrone [(1992) Journal of the Optical Society of America A, 9, 177-194] recently proposed a template-based model of self-motion estimation which uses directionand speed-tuned input sensors similar to neurons in area MT of primate visual cortex. Such an approach would generally require an unrealistically large number of templates (five continuous dimensions). However, because primates, including humans, have a number of oculomotor mechanisms which stabilize gaze during locomotion, we can greatly reduce the number of templates required (two continuous dimensions and one compressed and bounded dimension). We therefore refined the model to deal with the gaze-stabilization case and extended it to extract heading and relative depth simultaneously. The new model is consistent with previous human psychophysics and has the emergent property that its output detectors have similar response properties to neurons in area MST.
Clinical features of patients with pancreatic neuroendocrine neoplasms : a retrospective analysis of 61 cases in a cancer center

Objective: To assess the clinicopathological features of patients with pancreatic neuroendocrine neoplasms (pNENs) in relation with clinical outcomes. Methods: A total of 61 patients with pNENs were enrolled in this study. Patients’ characteristics, treatment procedures, and clinical follow-up were retrospectively analyzed. Results: Among the 61 patients, 29 patients (47.5%) were men and 32 patients (52.5%) were women. 6 patients (9.8%) had functional pNENs and presented with diarrhea, flushing, sweating, palpitations or glucose abnormalities. At diagnosis, 31.1% (19/61) had a localized disease, 6.6% (4/61) presented with regional spread including lymph node metastases and/or extrapancreatic organ invasions, and 62.3% (38/61) had distant metastases. Liver was the most common site of metastasis. 58 cases were recorded with detailed pathological information, among which 42 patients (72.4%) were diagnosed as NET G1/G2, 16 patients (27.6%) were diagnosed as NEC G3. The chromogranin A (CgA) levels were elevated in the serum of patients with liver metastasis, unresectable tumors or a Ki-67 proliferative index ≥20%. The univariate analysis suggested that the WHO classification, stage, occurrence of liver metastasis and operative approaches were closely related to the prognosis of pNENs; while sex, age, tumor size and functional status were not. Conclusion: The pNENs are a heterogeneous group of neoplasms with diverse clinical manifestations and prognosis. Serum CgA is an indicator of tumor burden and proliferation. The WHO classification, stage, liver metastasis and operative approaches might closely relate to the prognosis of pNENs.
High Performance Computing and Economic Scenario Generation : Integrating Expert Forecasts into Plane Price Modeling as an Example

The problem at hand is the integration of expert forecasts for plane prices into a fully calibrated basic economy. The economy is simulated through an Economic Scenario Generator (ESG), which includes macroeconomic processes, interest rate term structures, etc. By defining the available best-case, worst-case, and mid-case forecasts to correspond to the 95%, the 50% and the 5% quantiles of the plane price distribution, one could describe the problem with the following optimization setting: min (βc,αc,i,δc′,σc,i) {‖ ( Q ( (ĨT,S) P̃ c,i,T,S(βc, αc,i, δ c, γ c,σc,i),q ) − F̃M ) W‖F } The tilded matrices represent simulation results, i.e. they have the dimension timesteps T and scenarios S. The function Q(M̃T,S ,q) : R ·S × [0, 1] → R ·q is mapping a matrix M̃T,S of simulated scenarios with dimension (T × S) onto each timestep’s quantiles q , resulting in a matrix of dimension T × q. FM is the (T × q) matrix of expert forecasts, and W is a (T × q) weighting matrix. ‖‖F denotes the Frobenius norm, and is the element-wise multiplication. The economy simulation is computation-intensive, for which we take benefit of using GPGPU techniques. The optimisation part is also a high-dimensional computationintensive problem, for which we use a natural computing approach using Differential Evolution.
Examining the relationship between maternal employment and health behaviours in 5-year-old British children

Background: There is little known about potential mechanisms underlying the association between maternal employment and childhood obesity. The relationships between maternal hours worked per week (none, 1–20 hours, 21+ hours) and children’s dietary and physical activity/inactivity habits were examined. Where mothers were employed, the relationships between flexible work arrangements and these health behaviours were also examined. Methods: Data from 12 576 singleton children age 5 years in the UK Millennium Cohort Study were analysed. Mothers reported information about their employment patterns. Mothers also reported on indicators of their child’s dietary (crisps/sweets, fruit/vegetables, sweetened beverage, fruit consumption), physical activity (participation in organised exercise, transport to school) and inactivity (television/computer use) habits at age 5. Results: After adjustment for potential confounding and mediating factors, children whose mothers worked part-time or full-time were more likely to primarily drink sweetened beverages between meals (compared to other beverages), use the television/computer at least 2 hours daily (compared to 0–2) or be driven to school (compared to walk/cycle) than children whose mothers had never been employed. Children whose mothers worked full-time were less likely to primarily eat fruit/vegetables between meals (compared to other snacks) or eat three or more portions of fruit daily (compared to two or fewer). Although in unadjusted analyses children whose mothers used flexible work arrangements engaged in healthier behaviours, relationships were no longer significant after adjustment. Conclusions: For many families the only parent or both parents are working. This may limit parents’ capacity to provide their children with healthy foods and opportunities for physical activity. Policies and programmes are needed to help support parents and create a health-promoting environment.
Plakophilin-2 and the migration, differentiation and transformation of cells derived from the epicardium of neonatal rat hearts

Abstract During development, epicardial cells act as progenitors for a large fraction of non-myocyte cardiac cells. Expression and function of molecules of the desmosome in the postnatal epicardium has not been studied. The objective of this study was to assess the expression of desmosomal molecules, and the functional importance of the desmosomal protein plakophilin-2 (PKP2), in epicardial and epicardium-derived cells. Epicardial explants were obtained from neonatal rat hearts. Presence of mechanical junction proteins was assessed by immunocytochemistry. Explants after PKP2 knockdown showed increased abundance of alpha smooth muscle actin-positive cells, increased abundance of lipid markers, enhanced cell migration velocity and increased abundance of a marker of cell proliferation. We conclude that a population of non-excitable, cardiac-resident cells express desmosomal molecules and, in vitro, show functional properties (including lipid accumulation) that depend on PKP2 expression. The possible relevance of our data to the pathophysiology of arrhythmogenic right ventricular cardiomyopathy, is discussed.
Tyrosine residues that control binding and gating in the 5-HT 3 receptor revealed by unnatural amino acid mutagenesis

George Grant Hoag Professor of Chemistry: Dennis Dougherty Visiting Associate: Johannes Schwarz Members of the Professional Staff: Bruce Cohen, Cesar Labarca Associate Biologist: Purnima Deshpande Postdoctoral Fellows: Daniel Clayton, David Dahan, Mohammed Dibas, Carlos Fonck, Joanna Jankowsky, John Leite, Fraser Moss, Raad Nashmi, Rigo Pantoja, Nivalda Rodrigues-Pinguet, Irina Sokolova, Andrew Tapper Graduate Students: Darren Beene, Kiowa Bower, Amanda Cashin, Princess Imoukhuede, Lori Lee, Kathryn McMenimen, Sarah Monahan, Tingwei Mu, E. James Petersson, Erik Rodriguez, George Shapovalov, Eric Slimko, Steve Spronk, Michael Torrice, Joanne (Xinan) Xiu, Niki Zacharias Rotating Graduate Student: William Ford Research and Laboratory Staff: Pamela Fong, Kathleen Hamilton, Steven Kwoh, Rain Lynham, Sheri McKinney SURF Students: Jose Munoz, Lydia Ng Volunteers: Stephanie Huang, Sigrid Schwarz Division of Chemistry and Chemical Engineering, California Institute of Technology Division of Physics, Mathematics and Astronomy, California Institute of Technology
ANTHROPOMETRY AND BODY COMPOSITION OF JAPANESE YOUNG MEN AND WOMEN.

THE application of measurements of body composition to the characterization of human nutritional status has been reviewed by Keys and Brozek (1953) and Brozek (1961). The study reported here was carried out between 1958 and 1960. Its purpose was to establish the criteria of body composition, skinfold thicknesses and body density, to apply these to the evaluation of the nutritional status in young Japanese men and women, and to compare them between races.
ANALOGY AS A TOOL FOR COMMUNICATING ABOUT INNOVATION

Many techniques have been developed to enhance innovative thinking within a company. However, many innovations never make it through the development process due to the difficulty inherent in communicating new ideas to others. This article discusses the obstacles to innovation that occur during the development process and how these obstacles can be overcome through the use of analogy. Described is an empirically derived seven-step process for constructing suitable analogies for communicating about innovations. The use of the seven-step processes to develop an analogy to communicate about an automotive "step-rim" innovation developed by General Motors and the lessons learned during the development of the analogy are also discussed.
Topological analysis of the Rhodobacter capsulatus PucC protein and effects of C-terminal deletions on light-harvesting complex II

A theoretical model for the cytoplasmic membrane topology of the Rhodobacter capsulatus PucC protein was derived and tested experimentally with pucC'::pho'A gene fusions. The alkaline phosphatase (AP) activities of selected fusions were assayed, and the resultant pattern of high and low activity was compared with that of the theoretical model. High AP activity correlated well with fusion joints located in regions predicted to be periplasmic, and most fusions in predicted cytoplasmic loops yield approximately 1/20th as much activity. Replacement of pho'A with lac'Z in nine of the fusions confirmed the topology, as beta-galactosidase activities were generally reciprocal to the corresponding AP activity. On the basis of the theoretical analysis and the information provided by the activities of fusions, a model for PucC topology in which there are 12 membrane-spanning segments and both the N and C termini are located in the cytoplasm is proposed. Translationally out-of-frame pucC::phoA fusions were expressed in an R. capsulatus delta pucC strain. None of the fusions missing only one or two of the proposed C-terminal transmembrane segments restored the wild-type phenotype, suggesting that the C terminus of PucC is important for function.
Opportunity for Sexual Selection and Effective Population Size in the Lek-Breeding European Treefrog (Hyla arborea).

Sexual selection in lek-breeding species might drastically lower male effective population size, with potentially important consequences for evolutionary and conservation biology. Using field-monitoring and parental-assignment methods, we analyzed sex-specific variances in breeding success in a population of European treefrogs, to (1) help understanding the dynamics of genetic variance at sex-specific loci, and (2) better quantify the risk posed by genetic drift in this species locally endangered by habitat fragmentation. The variance in male mating success turned out to be markedly lower than values obtained from other amphibian species with polygamous mating systems. The ratio of effective breeding size to census breeding size was only slightly lower in males (0.44) than in females (0.57), in line with the patterns of genetic diversity previously reported from H. arborea sex chromosomes. Combining our results with data on age at maturity and adult survival, we show that the negative effect of the mating system is furthermore compensated by the effect of delayed maturity, so that the estimated instantaneous effective size broadly corresponded to census breeding size. We conclude that the lek-breeding system of treefrogs impacts only weakly the patterns of genetic diversity on sex-linked genes and the ability of natural populations to resist genetic drift.
Tailoring gold nanostructures for near-field optical applications

A method of combined thin-film deposition, electron beam lithography, and ion milling is presented for the fabrication of gold and silver nanostructures. The flexibility of lithographical processes for the variation of geometric parameters is combined with three-dimensional control over the surface evolution. Depending on the etching angle, different shapes ranging from cones over rods to cups can be achieved. These size- and shape-tunable structures present a toolbox for nano-optical investigations. As an example, optical properties of systematically varying structures are examined in a parabolic mirror confocal microscope.
Residue‐level global and local ensemble‐ensemble comparisons of protein domains

Many methods of protein structure generation such as NMR‐based solution structure determination and template‐based modeling do not produce a single model, but an ensemble of models consistent with the available information. Current strategies for comparing ensembles lose information because they use only a single representative structure. Here, we describe the ENSEMBLATOR and its novel strategy to directly compare two ensembles containing the same atoms to identify significant global and local backbone differences between them on per‐atom and per‐residue levels, respectively. The ENSEMBLATOR has four components: eePREP (ee for ensemble‐ensemble), which selects atoms common to all models; eeCORE, which identifies atoms belonging to a cutoff‐distance dependent common core; eeGLOBAL, which globally superimposes all models using the defined core atoms and calculates for each atom the two intraensemble variations, the interensemble variation, and the closest approach of members of the two ensembles; and eeLOCAL, which performs a local overlay of each dipeptide and, using a novel measure of local backbone similarity, reports the same four variations as eeGLOBAL. The combination of eeGLOBAL and eeLOCAL analyses identifies the most significant differences between ensembles. We illustrate the ENSEMBLATOR's capabilities by showing how using it to analyze NMR ensembles and to compare NMR ensembles with crystal structures provides novel insights compared to published studies. One of these studies leads us to suggest that a “consistency check” of NMR‐derived ensembles may be a useful analysis step for NMR‐based structure determinations in general. The ENSEMBLATOR 1.0 is available as a first generation tool to carry out ensemble‐ensemble comparisons.
Coping With Chronic Illness

Families suffer in many ways when a member is stricken with chronic illness. Nurses frequently feel as sense of frustration when working with the chronically ill because cure is not possible. The author reviews the goals of care and coping tasks common to the chronically ill. Family coping styles are reviewed with suggestions for effective nurse behaviors with each style.
Factor Analysis of Computerized and Traditional Tests Used in Mild Brain Injury Research

The present study examines the relation between a set of computerized neuropsychological measures, Automated Neuropsychological Assessment Metrics (ANAM), and a set of traditional clinical neuropsychological tests. Both sets of tests have been employed in recent studies of mild brain injury. Factor analysis and stepwise regression indicate that both sets of tests measure similar underlying constructs of cognitive processing speed, resistance to interference, and working memory. The present findings indicate strong concordance between computerized and traditional neuropsychological measures and support the construct validity of ANAM and similar procedures.
Adolescents Are More Likely to Develop Posttransplant Lymphoproliferative Disorder After Primary Epstein-Barr Virus Infection Than Younger Renal Transplant Recipients

Background. Primary Epstein-Barr virus (EBV) infection is the most important risk factor for development of posttransplant lymphoproliferative disorder (PTLD). Pediatric patients are often EBV seronegative pretransplant placing them at high risk. In the immune-competent population, primary herpesvirus infection is associated with higher morbidity with increasing age. Methods. We performed a retrospective cohort study to describe the outcome of pediatric renal transplant recipients with primary EBV infection. All patients received 3 months of ganciclovir prophylaxis. Real-time quantitative polymerase chain reaction was used to determine the EBV viral load. Primary EBV infection was categorized as PTLD, symptomatic infection, or subclinical infection. Results. There were a total of 46 patients with primary EBV infection: 11 developed PTLD, 12 had symptomatic infection, and 23 had subclinical infection. Adolescents were significantly more likely to develop PTLD than younger transplant recipients (P=0.05, chi-square). Multivariate analysis using logistic regression found that older age was the only significant risk factor for PTLD (odds ratio 1.24, 95% confidence interval 1.04–1.47; P=0.03). Among the 11 cases of PTLD, there were two deaths and two graft failures which all occurred in adolescent recipients (P=0.002). Conclusions. Among pediatric renal transplant recipients with primary EBV infection, adolescents are at significantly higher risk to develop PTLD and have poorer outcomes compared to younger recipients.
Soft-switching H7 current source inverter

This paper proposes a soft-switching DC-AC H7 current source inverter (CSI) with an auxiliary circuitry on DC side and a traditional H6 inverter bridge, which utilizes CSI boost characteristic and combines the unique advantage of shunt-connected switch in H7 CSI. With the presented shoot-through modulation strategy, the H7 CSI front-end switch is able to work at zero voltage transition (ZVT) mode, and realize zero current switching (ZCS) for the rear-end CSI circuitry. The proposed current source inverter could achieve soft switching ability for all power switches, and meanwhile guarantee the excellent performance with higher switching frequency. To some extent, the proposed soft-switching H7 current source inverter circuitry could be a promising solution for all CSI systems. MATLAB simulations with PSIM models and experimental verifications have been presented to show the performance of the proposed inverter.
SimAGC - An open-source power system dynamic simulator for AGC study

This paper presents an open-source software, namely SimAGC, for power system dynamic simulation. As its name suggests, SimAGC mainly focuses on system frequency response study and evaluating the performance of automatic generation control (AGC) with detailed modeling of system network, generator, governor-turbine, and the frequency dependence characteristics of loads. In addition, two AGC performance criteria (i.e. CPS1 and CPS2) recommended by North American Reliability Corporation (NERC) are provided for compliance evaluation. The graphic user interface and open architecture makes SimAGC a valuable tool for educational and research purposes.
Repeat and first time visitation in an experience specific context: the Valley of the Giants Tree Top Walk.

Communication with the public is a primary consideration in the design of natural area tourist attractions (Manfredo & Bright,1991; Roggenbuck, 1992; Vogt & Stewart, 1998). In a management context, communication is essential in ensuring a relevant and enjoyable experience on the part of the visiting tourists (Magill, 1995). Communication also serves as an important management aid in reminding visitors of appropriate behaviour while ensuring continued visitor interest in the attraction (Moscardo, 1998; Moscardo & Woods,2001). This paper presents the results of a . survey examining motivations and attitudes of repeat and first time visitors to the Tree Top Walk site in the context of the communication strategy used at the site.
Interactions of Fibrillin-1 with Heparin/Heparan Sulfate, Implications for Microfibrillar Assembly*

Fibrillin-1 is a major constituent of the 10–12 nm extracellular microfibrils. Here we identify, characterize, and localize heparin/heparan sulfate-binding sites in fibrillin-1 and report on the role of such glycosaminoglycans in the assembly of fibrillin-1. By using different binding assays, we localize two calcium-independent heparin-binding sites to the N-terminal (Arg45–Thr450) and C-terminal (Asp1528–Arg2731) domains of fibrillin-1. A calcium-dependent-binding site was localized to the central (Asp1028–Thr1486) region of fibrillin-1. Heparin binding to these sites can be inhibited by a highly sulfated and iduronated form of heparan sulfate but not by chondroitin 4-sulfate, chondroitin 6-sulfate, and dermatan sulfate, demonstrating that the heparin binding regions represent binding domains for heparan sulfate. When heparin or heparan sulfate was added to cultures of skin fibroblasts, the assembly of fibrillin-1 into a microfibrillar network was significantly reduced. Western blot analysis demonstrated that this effect was not due to a reduced amount of fibrillin-1 secreted into the culture medium. Inhibition of the attachment of glycosaminoglycans to core proteins of proteoglycans by β-d-xylosides resulted in a significant reduction of the fibrillin-1 network. These studies suggest that binding of fibrillin-1 to proteoglycan-associated heparan sulfate chains is an important step in the assembly of microfibrils.
A modified fast marriage in honey bee optimization algorithm

In this paper we present a modified version of an existing honey bee optimization algorithm: the modified fast marriage in honey bee optimization (MFMBO). Then we compare performances of this new algorithm and three existing bee algorithms, i.e. the artificial bee colony (ABC), the queen bee (QB), and the fast marriage in honey bee optimization (FMBO) on four benchmark functions for various numbers of variables up to 100. The obtained results show that the modified algorithm is faster than the others in most cases. Especially for Griewank and Schwefel functions by increasing precision of answer and number of variables, the difference between the speeds of the FMBO and MFMBO becomes prominent. In general the MFMBO algorithm is quite competitive with the other mentioned algorithms.