Miracle-dz/UniFAR-FTUs huggingface dataset:
Application of response surface methodology for investigation of membrane fouling behaviours in microalgal membrane bioreactor: the effect of aeration rate and biomass concentration

This study was performed to investigate membrane fouling phenomena and to optimize fouling parameters in a submerged membrane bioreactor. An ideal experimental design was carried out based on central composite design (CCD) with response surface methodology (RSM). This RSM was used to calculate the effects of microalgae concentration, aeration rate and their interaction with membrane fouling and permeate flux. Based on the analysis of variance (ANOVA), the permeate flux model proved to be of very good fit with a very low probability value (<0.0001). High permeate flux occurred at low microalgae concentrations and optimum aeration rate (2.5 L min−1). Minimum total resistance was 2.65 × 10−11 m−1 at optimum aeration rate and microalgae concentration of 0.65 g L−1. Furthermore, a high microalgae concentration released larger amounts of extra-cellular polysaccharides (EPS), resulting in severe fouling.
A Higher Playing Standard, Bowling, and Intermittent Helmet Use Are Related to a Greater Odds of Injury or Concussion in Cricket

Objective: To determine if playing position, a higher playing standard, and nonhelmet use are related to an increased odds of joint-specific injury and concussion in cricket. Design: Cross-sectional cohort. Participants: Twenty-eight thousand one hundred fifty-two current or former recreational and high-performance cricketers registered on a national database were invited to participate in the Cricket Health and Wellbeing Study. Eligibility requirements were aged ≥18 years and played ≥1 cricket season. Independent Variables: Main playing position (bowler/batter/all-rounder), playing standard (high-performance/recreational), and helmet use (always/most of the time/occasionally/never). Main Outcome Measures: Cross-sectional questionnaire data included cricket-related injury (hip/groin, knee, ankle, shoulder, hand, back) resulting in ≥4 weeks of reduced exercise and self-reported concussion history. Crude and adjusted (adjusted for seasons played) odds ratios and 95% confidence interval (CIs) were estimated using logistic regression. Results: Of 2294 participants (59% current cricketers; 97% male; age 52 ± 15 years; played 29 ± 15 seasons; 62% recreational cricketers), 47% reported cricket-related injury and 10% reported concussion. Bowlers had greater odds of hip/groin [odds ratio (95% CI), 1.9 (1.0-3.3)], knee [2.0 (1.4-2.8)], shoulder [2.9 (1.8-4.5)], and back [2.8 (1.7-4.4)] injury compared with batters. High-performance cricketers had greater odds of injury and concussion than recreational cricketers. Wearing a helmet most of the time [2.0 (1.4-3.0)] or occasionally [1.8 (1.3-2.6)] was related to higher odds of self-reported concussion compared with never wearing a helmet. Concussion rates were similar in cricketers who always and never wore a helmet. Conclusions: A higher playing standard and bowling (compared with batting) were associated with greater odds of injury. Wearing a helmet occasionally or most of the time was associated with higher odds of self-reported concussion compared with never wearing a helmet.
Explaining the Variability in School Nurse Workload and Educational Outcomes

This secondary analysis examined the variability in the effects of school nurse workload on individual student outcomes of 9th grade attendance, being on track to graduate, and high school graduation. A principal axis factor analysis of the variables underlying school nurse workload and a structural equation model of the latent construct school nurse workload in 5th grade and the three outcome variables was tested using data from student records (N = 3,782). Two factors explained 82% of the variability in school nurse workload: acuity and volume factor and social determinants of health factor. The model had acceptable fit indices and school nurse workload explained between 35% and 52% of the variability in the outcomes with a moderate effect size (.6–.72). Creating school nurse workload assignments that maximize student educational outcomes may improve graduation from high school, which in turn increases the resources available for lifelong health.
First report of field cases of Y280-like LPAI H9N2 strains in South Korean poultry farms: pathological findings and genetic characterization

ABSTRACT H9N2 low-pathogenic avian influenza (LPAI) viruses have long been circulating in the world poultry industry, resulting in substantial economic losses. In addition to bird health consequences, viruses from specific lineages such as G1 and Y280 are also known to have the potential to cause a pandemic within the human population. In South Korea, after introducing inactivated H9N2 vaccines in 2007, there were no field outbreaks of H9N2 LPAI since 2009. However, in June 2020, an H9N2 virus was isolated from an outbreak in a Korean chicken farm. This strain was distinct from the predominant Korean/Y439 lineage and was believed to be part of the Y280-like lineage. Since the first case of this new H9N2 LPAI, nine more cases of field infections in poultry farms were documented through July and December of 2020. Phylogenetic analysis of the haemagglutinin (HA) and neuraminidase genes of these case isolates revealed that all strains were grouped with exotic Y280-like strains that did not previously exist in South Korea and were emerging into a new cluster. Serological assays also confirmed the existence of antibodies to Y280-like viruses in field sera collected from infected birds, and that they had seroconverted. Further analysis of the receptor-binding region in the HA protein also revealed that these isolates harboured a human-like motif that could potentially affect mammals and humans, demonstrating a possible public health risk. This is the first report of field cases caused by Y280-like H9N2 LPAI in the Korean poultry industry. RESEARCH HIGHLIGHTS Field outbreaks caused by Y280-like H9N2 avian influenza viruses were confirmed. A human-like motif was found at the HA receptor-binding region of all isolates.
Modeling the impacts of clinical influenza testing on influenza vaccine effectiveness estimates.

BACKGROUND Test-negative design studies for evaluating influenza vaccine effectiveness (VE) enroll patients with acute respiratory infection. Enrollment typically occurs before influenza status is determined, resulting in over-enrollment of influenza-negative patients. With availability of rapid and accurate molecular clinical testing, influenza status could be ascertained prior to enrollment, thus improving study efficiency. We estimate potential biases in VE when using clinical testing. METHODS We simulate data assuming 60% vaccinated, 25% of those vaccinated are influenza positive, and VE of 50%. We show the effect on VE in five scenarios. RESULTS VE is affected only when clinical testing preferentially targets patients based on both vaccination and influenza status. VE is overestimated by 10% if non-testing occurs in 39% of vaccinated influenza-positive patients and 24% of others; and if non-testing occurs in 8% of unvaccinated influenza-positive patients and 27% of others. VE is underestimated by 10% if non-testing occurs in 32% of unvaccinated influenza-negative patients and 18% of others. CONCLUSIONS Although differential clinical testing by vaccine receipt and influenza positivity may produce errors in estimated VE, bias in testing would have to be substantial and overall proportion of patients tested would have to be small to result in a meaningful difference in VE.
Pre- and post-immigration factors associated with cigarette use among young adult recent Latinx immigrants during their initial year in the U.S

ABSTRACT Background: Evidence indicates escalating rates of cigarette use among foreign-born Latinx as their time in the U.S increases. As such, it’s important to understand shifts in pre- to post-immigration smoking patterns early in the immigration process and its associated factors. Objectives: To examine 1) cigarette use among recent Latinx immigrants (RLIs) during their initial year in the U.S.; 2) whether cigarette use after immigration is influenced by smoking patterns in immigrant’s country of origin; and 3) associations between pre/post immigration sociocultural factors and changes in cigarette use after immigration. Methods: Baseline data were utilized from an on-going longitudinal study of 540 young adult (50% females) RLIs. Inclusion criteria was being between ages 18 and 34, residing in Miami-Dade County, Florida, and having immigrated from a Latin American country within the past year Results: Approximately 31% of participants reported being smokers in their country of origin while 26% were current smokers (while residing in the U.S). Post-immigration cigarette use was substantially influenced by country of origin cigarette use (V = .68); 84% of pre-immigration smokers reported no change in smoking frequency, while 11% lowered and 6% increased their cigarette use post-immigration. Reduction in smoking after immigration was more likely among participants with higher pre-immigration social support (aOR = 1.87) and less likely among those residing in high-crime neighborhoods (aOR = .84). Conclusion: Interventions aimed to discourage cigarette use should begin early in the immigration process and account for RLIs’ pre-immigration smoking patterns. Interpersonal supports and neighborhood contextual factors should be considered when developing smoking cessation programs with this population.
CuO nanowires synthesized by thermal oxidation route

CuO nanowires were prepared on the copper foil by thermal oxidation in air. The effect of annealing temperature and growth time on the morphology of the nanowires is investigated. It is found that the annealing temperature and the growth time play an important role in the morphology of CuO nanowires such as the density, the length and the diameter. The length and the density of nanowires increase with prolonging growth time; but if the time is too long, CuO crystallite grains form instead of nanowires. Annealing copper foils at lower or higher temperature, the density of nanowires is lower. For comparison, the Cu ﬁlms on Si substrate deposited by direct current (dc) magnetron sputtering are oxidized, but we do not ﬁnd large-scale of nanowires. The possible mechanism is also discussed for the growth of CuO nanowires.
Alleviation of Pesticide Residue in Surface Water

Reduction of environmental pollution incurred from pesticide use is very important. Zeolite is a natural mineral capable of removing certain chemical contaminants from water. This study was carried out to test the effect of zeolite treatment on pesticide residue alleviation in surface water. Ten surface water samples were treated with natural zeolite by filtering through. An EPA method was used to extract pesticide residue from the water samples and the surfactant used to modify the net charge on the zeolite was hexadecyltrimethylammonium chloride (HDTMA-Cl). Gas chromatography-mass spectrometry was used to analyze water samples. Alleviation was achieved in all the 10 water samples that were filtered through zeolite. The highest removal of pesticides from water with zeolite included 100% of bifenthrin in sample CLC, atrazine in BPH, CDG and LBT; metolachlor in CLC, LBT, BCH, TRH2 and BPI; acetolachlor in BBH and BCH; azoxystrobin in BBH; desethylatrazine in BCH and BPI; metribuzin in BCH, TRH2 and BPI; and both clomazone and bromacil in sample BDC. A minimum reduction of 10.9% was found for metolachlor in sample BRH. Further reduction of pesticide residues up to 50% was recorded in the SMZ treatment as the concentrations of 4 out of 8 pesticide residues were reduced. This study confirms the potential of both the natural zeolite-Clinoptilolite, and SMZ of alleviating pesticide residues in water.
A 5-Minute Cognitive Assessment for Safe Remote Use in Patients With COVID-19: Clinical Case Series

Background Early clinical experience during the COVID-19 pandemic has begun to elucidate that the disease can cause brain function changes that may result in compromised cognition both acutely and during variable recovery periods. Reports on cognitive assessment of patients with COVID-19 are often limited to orientation alone. Further assessment may seem to create an inappropriate burden for patients with acute COVID-19, which is characterized by fatigue and confusion, and may also compromise examiner safety. Objective The aims of this study were to assess cognition in patients with COVID-19 as comprehensively as possible in a brief format, while observing safety precautions, and to establish a clear face value of the external validity of the assessment. Methods We adapted a brief cognitive assessment, previously applied to liver transplant candidates and medical/surgical inpatients, for remote use in patients hospitalized for COVID-19 treatment. Collecting quality assurance data from telephone-administered assessments, this report presents a series of 6 COVID-19 case vignettes to illustrate the use of this 5-minute assessment in the diagnosis and treatment of brain effects. Primary medical teams referred the cases for neuropsychiatric consultation. Results The age of the patients varied over four decades, and none of them were able to engage meaningfully with their surroundings on admission. On follow-up examination 6 to 10 days later, 4 of the 6 patients had recovered working memory, and only 1 had recovered calculation ability. Of the 6 patients, 2 were capable of complex judgment responses, while none of the cases completed frontal executive function testing in the normal range. Conclusions Cognitive assessment in patients with COVID-19 using this remote examination reveals patterns of cognitive recovery that vary among cases and are far more complex than loss of orientation. In this series, testing of specific temporal, parietal, and frontal lobe functions suggests that calculation ability, judgment, and especially frontal executive functions may characterize the effects of COVID-19 on the brain. Used widely and serially, this examination method can potentially inform our understanding of the effects of COVID-19 on the brain and of healing from the virus.
Commentary: Potential transmissibility of SARS-CoV-2 infection via donor corneal tissue

At the peak of the pandemic, the majority of the affected nations delayed elective surgical procedures, and a temporary suspension of donor cornea retrieval and corneal transplantation surgeries was advised. As our understanding of the disease continues to evolve, there has been a simultaneous restructuring of our health care services and modification of the existing treatment guidelines. Donor cornea retrieval and corneal transplant surgeries have gradually resumed in a majority of centers; however, there is a lack of consensus regarding the guidelines for donor retrieval and testing. The pertinent questions surrounding the restoration of eye-banking services include addressing the potential for donor-tissue-related transmission of COVID-19, revision of the donor eligibility criteria as well as the utility and feasibility of routine COVID-19 testing of the donor as well as the recipient.
Assessment of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker on the split renal function in the patients with primary hypertension

Abstract Bilateral kidney damage in hypertensive patients is not parallel. Angiotensin-converting enzyme inhibitor/angiotensin receptor blocker (ACEI/ARB), as a commonly used antihypertensive drug, could protect kidney function and delay its deterioration. Most studies focused on overall renal function, but the researches on split renal function (SRF) are rare. We investigated the effects of ACEI/ARB on the SRF in patients with primary hypertension. Patients with primary hypertension (n = 429; male: 213; female: 216) admitted to our department between January 2014 and December 2016 were included in this study. The glomerular filtration rate (GFR) of split and total renal function were determined using diethylenetriaminepentaacetic acid tagged with 99mTc renal dynamic imaging method. For the same patient, the side with high GFR was considered as higher GFR kidney, whereas that with a low GFR was considered as lower GFR kidney. The split function score (Q value) was utilized to evaluate the differences of bilateral renal function. The patients were divided into 3 groups based on the Q values (Group 1, Q value <5%; Group 2, Q value of 5%–10%; Group 3, Q value ≥10%). All the patients received antihypertensive therapy based on ACEI/ARB. The renal dynamic imaging was performed in the 1-year follow-up to investigate the changes of the SRF. Compared with the baseline level, significant decline was noticed in the serum creatinine (Scr) in Group 2 and Group 3 (P < .05). The cystatin C in Group 3 showed significant decline (P < .05). Compared with the baseline, there was significant decline in the Q value in Group 2, whereas the GFR of lower GFR kidney showed significant increase (P < .05). No statistical differences were noticed in the Q value and split GFR in Group 1 and Group 3 (P > .05). In primary hypertension patients, ACEI/ARB therapy could improve the SRF of lower GFR kidney in the presence of certain differences between the SRF. As a result, the SRF difference was reduced. In case of Q value in a range of 5% to 10%, ACEI/ARB could improve the renal function effectively. It may be significant for the design of antihypertensive drugs.
How personality traits of neuroticism and extroversion predict the effects of the COVID-19 on the mental health of Canadians

The Coronavirus Disease (COVID-19) epidemic was first detected in China in December 2019 and spread to other countries fast. Some studies have found that COVID-19 pandemic has had adverse mental health consequences. Individual differences such as personality could contribute to people’s behaviors during a pandemic. In the current study, we examine how personality traits of neuroticism and extroversion (using the Five-Factor Model as our framework) are related to the mental health of Canadians during the COVID-19 pandemic. Using data from an online survey with 1096 responses, this study performed multiple regression analysis to explore how personality traits of neuroticism and extroversion predict the effects of COVID-19 on the mental health of Canadians. The results showed that personality traits of neuroticism and extroversion are associated with the current mental health of Canadians during COVID-19 pandemic, with extroversion positively related to mental health and neuroticism negatively related to it. Results contribute to the management of individual responses to the COVID-19 pandemic and could help public health services provide personality-appropriate mental health services during this pandemic.
Breast Cancer Survival in Multiple Sclerosis

Objective To test the hypotheses that overall survival and cancer-specific survival after breast cancer diagnosis would be lower in persons with multiple sclerosis (MS) as compared to persons without MS using a retrospective matched cohort design. Methods We applied a validated case definition to population-based administrative data in Manitoba and Ontario, Canada, to identify women with MS. We linked the MS cohorts to cancer registries to identify women with breast cancer. Then we selected 4 breast cancer controls without MS matched on birth year, cancer diagnosis year, and region. We compared all-cause survival between cohorts using Cox proportional hazards regression adjusting for age at cancer diagnosis, cancer diagnosis period, income quintile, region, and Elixhauser comorbidity score. We compared cancer-specific survival between cohorts using a multivariable cause-specific hazards model. We pooled findings between provinces using meta-analysis. Results We included 779 patients with MS and 3,116 controls with breast cancer. Most patients with stage data (1,976/2,822 [70.0%]) were diagnosed with stage I or II breast cancer and the mean (SD) age at diagnosis was 57.8 (10.7) years. After adjustment for covariates, MS was associated with a 28% increased hazard for all-cause mortality (hazard ratio [HR] 1.28; 95% confidence interval [CI] 1.08–1.53), but was not associated with altered cancer-specific survival (HR 0.98; 95% CI 0.65–1.46). Conclusion Women with MS have lower all-cause survival after breast cancer diagnosis than women without MS. Future studies should confirm these findings in other populations and identify MS-specific factors associated with worse prognosis.
Prevalence of HIV-related stigma in adults living with HIV & disability in Florida, 2015–2016

ABSTRACT Using data collected from the Florida Medical Monitoring Project, we sought to compare the prevalence of overall HIV-related stigma, including its subdimensions among persons with HIV and disability(s) and persons with HIV without disability in Florida. Disability was classified as having difficulty in one or more areas: activity limitations, participation restrictions, and functional or sensory activities. HIV-related stigma was assessed using the HIV Stigma Scale, which measures (1) overall stigma (2) negative self-image, (3) personalized, and (4) anticipated stigma. Multivariate analysis indicates that the crude prevalence ratios of overall stigma, including negative self-image, personalized, and anticipated stigma among persons with HIV and disability(s) were 1.43, 1.24, 1.20, and 1.23 compared to persons with HIV without disability, respectively. After adjusting for confounders, the prevalence ratios of HIV-related stigma ranged from 1.33–1.07 among persons with HIV and disability(s) compared to persons with HIV without disability. The implications of these findings reveal that persons with HIV and disability(s) are more vulnerable to HIV-related stigma. Researchers could consider distinct stigma interventions tailored towards persons with HIV and disability(s) in Florida.
Stargardt disease: Multimodal imaging: A review

Stargardt disease (STGD1) is an autosomal recessive retinal dystrophy, characterised by bilateral progressive central vision loss and subretinal deposition of lipofuscin‐like substances. Recent advances in molecular diagnosis and therapeutic options are complemented by the increasing recognition of new multimodal imaging biomarkers that may predict genotype and disease progression. Unique non‐invasive imaging features of STDG1 are useful for gene variant interpretation and may even provide insight into the underlying molecular pathophysiology. In addition, pathognomonic imaging features of STGD1 have been used to train neural networks to improve time efficiency in lesion segmentation and disease progression measurements. This review will discuss the role of key imaging modalities, correlate imaging signs across varied STGD1 presentations and illustrate the use of multimodal imaging as an outcome measure in determining the efficacy of emerging STGD1 specific therapies.