Miracle-dz/UniFAR-FTUs huggingface dataset:
Search for an Herbal Medicine: Anti-Ulcer Activity of Methanolic Extract of Haldina cordifolia.

In this study, we were determining the anti-ulcer effect of Haldina cordifolia in NSAID induced rats. The methanolic extract was given orally 100mg/kg and 50 mg/kg body weight at 8 hrs interval. Diclofenac sodium was used as the inducing agent for the ulcer. The result was satisfactory as there is a marked improvement in the ulcerated part. The extract was able to decrease the acid secretion in stomach and increase the mucosal damage.
the correlation of serum galectin 3 level with the staging of chronic kidney disease coexistent with diabetes mellitus and with hypertension

The Correlation of Serum Galectin-3 Level with the Staging of Chronic Kidney Disease Coexistent with Diabetes Mellitus and with Hypertension. Abstract Background: Chronic Kidney Disease (CKD), characterized by significant proteinuria and reduction of estimated Glomerular Filtration Rate (eGFR), usually developed in coexistence
Acute and sub-acute oral toxicity assessment of hydro-alcoholic root extract of Paullinia pinnata on haematological and biochemical parameters

The trusted efficacy of Paullinia pinnata (Sapindaceae) that has made many people to patronize it despite the absence of toxicity studies emerges from its long history of use in Ghana. The aim of this study was to evaluate the acute and sub-acute toxicity effects of P. pinnata roots on biochemical and haematological indices in rats. The dried Paullinia roots after milling was macerated in 70% ethanol and concentrated to obtain the semi-solid extract. For the acute toxicity study, rats were exposed to dose levels of 2,000, 2,500, 3,000, and 5,000 mg/kg p.o. and monitored for 48–72 hours. Dose levels of 375, 750, and 850 mg/kg were used for the sub-acute toxicity studies. The results of haematological and biochemical parameters in the present study showed that the root extract of P. pinnata is potentially safe for oral consumption up to dose of 850 mg/kg.
POST SURGICAL WOUND INFECTIONS: A STUDY ON THREATS OF EMERGING RESISTANCE

bacterial isolates associated with post surgical wound infections were tested in vitro for their sensitivity/resistance pattern against 20 antibacterial agents. The study indicated that the bacteria in which clinically significant resistance has now become a potential problem include Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Proteus, Klebsiella, Staphylococcus epidermidis, Enterobacter and Citrobacter species. Among the tested drugs the percent resistance rate observed were tobramycin (9.75%), amikacin (10.03%), enoxacin (20.53%), ofloxacin (25.93%), ciprofloxacin (26.27%), gentamicin (29.03%), ceftrioxone (36%), aztreonam (41.07%), cefaclor (44.07%). The conclusion from the study can be drawn that tobramycin and amikacin (aminoglycosides) and enoxacin, ciprofloxacin and ofloxacin (Fluoroquinolones) are very effective agents for treating post surgical wound infections. However resistance to these agents is rapidly increasing.
Effect of Teaching Guidelines on Knowledge, Health Believes, and Self-Efficacy among Post-Menopausal Women with Osteoporosis

Background: Osteoporosis is a worldwide health problem with decreased bone mass and altered bone structure resulting in increased bone fragility and increased fracture risk. The aim of the current study was to evaluate the effect of teaching guidelines on knowledge, health believes, and self-efficacy of post-menopausal women with osteoporosis. A quasi-experimental research design was used to conduct the study at rheumatology outpatient clinic at Mansoura University hospitals, Egypt from the beginning of May 2015 to the end of August 2016. Subjects: A purposive sample of 80 post-menopausal women with osteoporosis included. Tools: Four tools were used in data collection; a structured interviewing questionnaire, Osteoporosis Knowledge Test, Osteoporosis Health Belief Scale, and Osteoporosis Self-Efficacy Scale. Results revealed that mean scores of knowledge, health believes, and self-efficacy among the study group had significantly increased after implementation of the teaching guidelines. Conclusion: The teaching guidelines were effective in improving mean scores of knowledge, health believes, and self-efficacy of the study subjects. Recommendation: Assuring the importance of implementing the teaching guidelines inside the osteoporosis units, replication of the study on large proportions.
Prévention primaire de la mort subite par défribrillateur implantable en situation usuelle : différences avec les études pivots et leurs conséquences

Contexte. – L’efficacite du defibrillateur implantable est aujourd’hui bien demontree en prevention primaire d’une mort subite cardiaque mais les etudes pivots ont plus de 10 ans et les conditions d’implantation tendent a changer. Objectifs. – Nous avons etudie les caracteristiques et le devenir des patients implantes en prevention primaire entre les 01/01/2009 et 31/12/2014 lorsqu’ils remplissaient les criteres d’inclusion de l’etude SCD-HeFT. Methodes. – Nous avons analyse retrospectivement les dossiers medicaux de 336 patients. Trois variables ont ete etudiees separement : la mortalite, l’incidence de premier traitement approprie delivre par le defibrillateur puis, plus particulierement, celle en zone de fibrillation ventriculaire. Ces variables ont ete comparees entre patients resynchronises ou non, entre ceux avec fraction d’ejection <30% ou ≥30% puis entre cardiopathies ischemiques et non ischemiques et en tenant compte de l’âge. Resultats. – Dans la population etudiee, la fraction d’ejection (mediane 29.5%) est plus elevee que dans SCD-HeFT et pres de 47% des patients sont resynchronises. Sur une duree mediane de 30 mois, 54 (16.1%) patients decedent, 43 (12.8%) recoivent au moins un traitement approprie dont 19 (5.7%) en zone FV. Concernant les variables etudiees, le risque de traitement approprie par le defibrillateur et celui de traitement en zone FV different significativement entre groupe resynchronise ou non (p=0.003 et p=0.04) mais pas la mortalite (p=0.86). Ces resultats persistent et s’amplifient dans le sous groupe des cardiopathies non-ischemiques mais pas pour les ischemiques. Aucune influence de la fraction d’ejection a l’implantation n’a ete mise en evidence. Conclusions. – Bien que notre population implantee ait effectivement une meilleure fraction d’ejection gauche et beneficie largement d’une resynchronisation avec, dans ce dernier cas, une diminution significative du risque de traitements appropries delivres par le defibrillateur, les resultats globaux en termes de survie et de traitement delivre restent tres proches de ceux de SCD-Heft. Cette etude ne peut donc remettre en cause le critere de fraction d’ejection ≤35% pour l’implantation d’un defibrillateur en prevention primaire. Elle souligne en revanche le besoin de mieux identifier les indications de defibrillateur parmi les candidats a la resynchronisation.
Determination of non-cholesterol sterols in serum and HDL fraction by LC/MS-MS: Significance of matrix-related interferences

Background Non-cholesterol sterols (NCS) are promising biomarkers for estimation of cholesterol homeostasis properties. In addition, determination of NCS in high-density lipoprotein (HDL) fraction (HDL-NCS) could provide information on cholesterol efflux. However, matrix effects interfere in liquid chromatography-mass spectrometry (LC-MS) analysis of NCS, thereby impairing the method sensitivity. The aims of this study were development, optimization and validation of LC-MS method for quantification of NCS in serum and HDL-NCS. Additionally, matrix effect interferences and methods application in individual serum samples were examined. Methods HDL precipitating reagent was used for HDL isolation. Matrix effect was examined by comparing different surrogates by simple regression analysis. Validation was conducted according to the FDA-ICH guideline. 20 healthy volunteers were recruited for testing of method application. Results The observed matrix effect was 30%, and matrix comparison showed that cholesterol was the dominant contributor to the matrix effect. Cholesterol concentration was adjusted by construction of the calibration curve for serum and HDL fraction (5 mmol/L and 2.5 mmol/L, respectively). The intraand interrun variabilities for NCSs were 4.7-10.3% for serum NCS and 3.6-13.6% for HDLNCS and 4.6-9.5% for serum NCSs and 2.5-9.8% for HDL-NCS, respectively. Recovery studies showed satisfactory results for NCSs: 89.8-113.1% for serum NCS and 85.3-95.8% for HDL-NCS. Conclusions The method was successfully developed and optimized. The matrix interference was solved by customising calibration curves for each method and sample type. The measurement of NCS in HDL fraction was proposed for the first time as potentially useful procedure in biomedical researches.
Comparative Analyses of the Dominant and Non-Dominant Upper Limbs during the Abduction and Adduction Motions

Background: Asymmetry in repeated motion may lead to dyskinesia through imbalance in the involved musculoskeletal structures. The dominance sides are also involved greater movement involvement over the non-dominant sides. The upper limbs with multiple joints and largest range of motion are prone for unsynchronized coordination. Natural movement analysis is required for application to everyday activities. Methods: Thirty participants were first recruited from Inha University, Incheon, Korea in 2019. Twenty subjects were assessed for comparisons of asymmetrical motion between the dominant and non-dominant arms during the abduction and adduction lateral raises after excluding ten subjects for shoulder pain and left-handedness. Results: The abduction and adduction motions of the bilateral arms were compared for the angular locations, velocity, and acceleration for every 10 degrees. The angular locations of the dominant side occurred significant earlier in the initial (10°, 20°, 30°) phase and later in the last (10°, 20°) phase of abduction and adduction in comparison to the non-dominant side (P<.05). The angular accelerations of the dominant side were also significantly greater during the initial phase (0°, 10°, 30°) and last phase (0°, 10°, 30°) (P <.05). The angular velocities were significantly greater during the later phase (40, 50, 60°) of abduction (P <.04). Conclusion: Comparative dominant side indicated more controlled movements through the range of motion with greater stability in angular acceleration and deceleration especially during the initial and last phase of abduction and adduction, respectively. Training for control of the specific angular points should be considered during abduction and adduction motions to prevent asymmetry of the bilateral arms.
THE ASSOCIATION BETWEEN SELECTED RANKL GENE POLYMORPHISMS AND CHRONIC/AGGRESSIVE PERIODONTITIS IN IRANIAN SUBJECTS

The primary aim of this study was to investigate the status of RANKL6-7 gene polymorphism in patients with chronic (mild, moderate, severe) and aggressive periodontitis as well as healthy controls. We examined 80 patients for the RANKL6-7 polymorphisms (rs1054016 and rs9567000). Polymorphism was determined by polymerase chain reaction (PCR) followed by direct sequencing. No statistically significant association was found between the polymorphism in the RANKL 7 gene and periodontal disease (P<0.55). There was also no polymorphic allele observed in RANKL 6 gene of the study population. We found no association between the studied RANKL polymorphisms and chronic/aggressive periodontitis.
Temporal trends in the accuracy of hospital diagnostic coding for identifying acute stroke: A population-based study

Introduction Administrative hospital diagnostic coding data are increasingly being used in identifying incident and prevalent stroke cases, for outcome audit and for ‘big data’ research. Validity of administrative coding has varied in previous studies, but little is known about the temporal trends of coding accuracy, which could bias analyses. Patients and methods Using all incident and recurrent strokes in a population-based cohort (Oxford Vascular Study/OXVASC) with multiple sources of ascertainment as the reference, we determined the temporal trends in sensitivity and positive predictive value of hospital diagnostic codes for identifying acute stroke from 2002 to 2017. Results Of 1883 hospitalised strokes, 1341 (71.2%) were correctly identified by coding. Sensitivity of coding improved over time for all strokes (ptrend = 0.005) and for incident cases (ptrend = 0.002). Of 1995 apparent stroke admissions identified by International Classification of Disease-10 stroke codes (I60–I68), 1588 (79.6%) used the stroke-specific codes (I60–I61/I63–I64). Positive predictive value was higher with the use of specific codes (83.2% vs. 69.2% for all codes) and highest if combined with the first admission only (88.5%), particularly during more recent time periods (2014–2017 = 90.3%). Of 2254 OXVASC incident strokes, 833 (37.0%) were not hospitalised. Sensitivity of coding increased over time for non-disabling stroke (ptrend = 0.001), but not for disabling/fatal stroke (ptrend = 0.40). Conclusions Although accuracy of hospital diagnostic coding for identifying acute strokes improved over the last 15 years, residual insensitivity supports linkage to other sources in large epidemiological studies. Moreover, differences in the time trends of coding sensitivity in relation to stroke severity might bias studies of trends in stroke outcome if only administrative coding is used.
THE ASSOCIATION BETWEEN RHEUMATOID ARTHRITIS, PERIODONTITIS AND ISCHEMIC HEART DISEASE

Patients with active rheumatoid arthritis (RA) have a significantly higher incidence of gum disease compared with healthy subjects, in RA patients the correlation with tooth and alveolar bone loss being demonstrated. It is interesting to study the relationship between the rheumatoid factor (RF), anti- cyclic citrullinated peptide antibodies (anti CCP), and Porphinomonas gingivalis (Pg), RF and anti CCP, present in RA, these being identified in the gum and in the subgingival plaque as well. The presence of gum disease increases the chance of developing heart disease, and mortality from cardiovascular damage in patients with RA, is 2 times higher compared to the general population. Based on these observations the question, whether oral infections play an important role in the pathogenesis of rheumatoid arthritis, and whether cardiovascular disease increases the risk in these patients, arises. Cuvinte cheie: poliartrită reumatoidă, parodontoză, boală cardiacă ischemică Rezumat: Pacienții cu poliartrită reumatoidă (PR) activă au o inciden ță semnificativ crescută a afectării gingivale in comparație cu subiecții sănătoși, la pacienții cu PR fiind demonstrată corelația cu pierderea dinților și a osului alveolar. Este interesantă studierea relației intre factorul reumatoid (FR), anticorpii antipeptidă ciclică citrulinată (atc anti CCP) și Porphinomonas gingivalis (Pg), FR și atc anti CCP, prezenți in PR, fiind identificați și in gingie și placa subgingivală. Prezența afecțiunilor gingivale crește șansa de apariție a bolilor cardiace, iar mortalitatea prin afectare cardiovasculară la pacienții cu PR este de 2 ori mai mare față de populația general ă. Pornind de la aceste observații se ridică intrebarea dacă infecțiile orale joacă un rol important in patogenia poliartritei reumatoide și dac ă acestea augmentează riscul de boală cardiovasculară la acești pacienți.
SeqFuzzer: An Industrial Protocol Fuzzing Framework from a Deep Learning Perspective

Industrial networks are the cornerstone of modern industrial control systems. Performing security checks of industrial communication processes helps detect unknown risks and vulnerabilities. Fuzz testing is a widely used method for performing security checks that takes advantage of automation. However, there is a big challenge to carry out security checks on industrial network due to the increasing variety and complexity of industrial communication protocols. In this case, existing approaches usually take a long time to model the protocol for generating test cases, which is labor-intensive and time-consuming. This becomes even worse when the target protocol is stateful. To help in addressing this problem, we employed a deep learning model to learn the structures of protocol frames and deal with the temporal features of stateful protocols. We propose a fuzzing framework named SeqFuzzer which automatically learns the protocol frame structures from communication traffic and generates fake but plausible messages as test cases. For proving the usability of our approach, we applied SeqFuzzer to widely-used Ethernet for Control Automation Technology (EtherCAT) devices and successfully detected several security vulnerabilities.
Preoperative opioid use in patients undergoing shoulder surgery

Background Opioids are commonly used to manage pain from acute injury or chronic degenerative diseases. The objective of this study was to assess the prevalence of preoperative opioid use in patients undergoing shoulder surgery and the clinical factors associated with preoperative opioid use. Methods This was an analytical cross-sectional study of 175 patients undergoing shoulder surgery at an urban hospital from June 2015 to June 2017. Multivariable regression models were used to determine independent associations. Results Fifty-three patients reported preoperative opioid use, which was significantly associated with primary procedure performed (Current Procedural Terminology [CPT]), higher body mass index (BMI), unemployment, lower income, smoking, higher American Society of Anesthesiologists score, greater number of previous surgeries, higher comorbidity burden, and decreased expectations to exercise and do recreational activities (p < 0.05). Preoperative opioid use was independently associated with worse scores on the: Numeric Pain Scale, ASES, IPAQ, and PROMIS domains of Physical Function, Pain Interference, and Social Satisfaction (p < 0.05). Conclusion More than one in four patients reported preoperative opioid use. Several health measures, including worse pain, function, and social satisfaction were independently associated with preoperative opioid use. These findings suggest that orthopaedic surgeons need to identify patients using opioids preoperatively in order to effectively establish and execute a plan for pain management, which may include weaning off opioids prior to surgery, managing psychological distress, and optimizing coping strategies. Level of Evidence: III.
CARDIOVASCULAR Anticoagulation monitoring during vascular surgery: accuracy of the Hemochronlow range activated clotting time (ACT-LR)

Background. Activated clotting time (ACT) is currently used to monitor high concentrations of heparin anticoagulation. A new instrument, the HemochronJr Signature device, has been specifically designed to measure ACT in low-range heparin plasma concentrations (ACT-LR). The purpose of this study was to compare ACT-LR with anti-Xa activity in patients receiving low-dose i.v. heparin during vascular surgery. Methods. Thirty patients, undergoing arterial vascular surgery, were included in the study and received unfractionated heparin (initial dose 50 u kg 1 ). One hundred and thirty-two pairs of blood samples were simultaneously collected during surgery to determine ACT-LR and anti-Xa activity. Pearson correlation, Kappa test, ROC curve and a specific clinical interpretation of the correlation were performed. Results. ACT-LR ranged from 68 to 380 s, anti-Xa activity from 0 to 1.45 u ml 1 . We observed a strong correlation between anti-Xa activity and ACT-LR (r 2 =0.87; P<0.0001). Accuracy of ACT-LR was good for anti-Xa activity up to 0.6 u ml 1 (Kappa, 0.94; accuracy, 97%) and 0.8 u ml 1 (Kappa, 0.79; accuracy, 90%), and poor for anti-Xa activity above 1 u ml 1 (Kappa, 0.59). A clinical interpretation of the correlation graph found 98% of measured ACT-LR values to be accurate. Conclusion. HemochronJr Signature provides measurements of ACT-LR, which are accurate for monitoring heparin anticoagulation at anti-Xa activity below 0.8 u ml 1 . Br J Anaesth 2006; 97: 453-9
Analytical Synthesis of External Perturbation Observer for Bilinear Dynamic System

We consider the problem of analytical synthesis of the external perturbation observer for a bilinear dynamic system with scalar input and vector output. It is shown that by a nondegenerate transformation of variables, the original problem can be reduced to the construction of a functional observer of the extended object state and solved using the previously proposed methods. Using the technology of matrix canonization we obtain the resulting equations of the nonlinear external perturbation observer in two versions: with and without differentiation of the output signal. We formulated conditions for the existence of an asymptotic observer of a minimal order and conditions of the provision of the required performance of the estimation process by using modal control methods. We propose a step-by-step algorithm for the analytical synthesis of an observer and give an example of its use.
DISEASE-FREE SURVIVAL OF BREAST CANCER PATIENTS AND IDENTIFICATION OF RELATED FACTORS

Background: Breast cancer is the most common cancer among women especially in eastern Mediterean region. Disease-free survival is common to evaluate the treatment of cancers. Several factors have been determined as prognostic factors for disease-free survival in studies. Methods: In this cross-sectional study, during 2005-2007, 153 women with breast cancer were treated in Fayazbakhsh hospital, Tehran. These patients had no metastasis at the time of diagnosis. Patients underwent MRM or BCS surgery. All patients followed until 2011 April. Metastases were diagnosed with x-ray, Biochemical methods, ultrasound with oncologist confirmation. A Cox’s regression with time to first event variable was used to determine the prognostic factors. Kaplan-Myer method was used to estimate the survival function. All statistical methods ran in R software version 2.10. Results: Out of 133 patients, 25(18.8%) died and 108(81.2%) were alive. Out of alive patients, 99(74.4%) without metastasis and 9 patients(6.8%) experienced a metastasis. Using Kaplan-Myer estimation showed that disease-free survival was 64 months, and five years rate of disease-free was 72 percent. Increasing in disease-free survival was associated with low grade of tumor, low number of involved lymph nodes, ER negative and HER2 negative. Odds ratio of metastasis or death for HER2 positive was 2.46 times of HER2 negative. Patients with grade 3 had risk of metastasis 1.69-fold of grade2. Conclusion: The result of this study showed that HER2, ER, Grade and number of involved lymph nodes were prognostic factors. Age, size of tumor and PR were not identified as prognostic factors.