Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effects of an Educational Program on Recognition of Atypical Signs and Symptoms of Acute Coronary Syndrome in Women in the Emergency Room

The Effects of an Educational Program on Recognition of Atypical Signs and Symptoms of Acute Coronary Syndrome in Women in the Emergency Room Robert E. Wynn Jr, MSN, FNP-BC, BCEN According to the American Heart Association (2010), in the United States every 36 seconds someone dies from heart and blood vessel disease. The Centers for Disease Control and Prevention (2007) estimate that one in six deaths in the US is related to coronary artery disease. When diagnosed with acute coronary syndrome, which is an acute event, resulting from CAD, appropriate treatment greatly reduces the risk of refractory ischemia, need for urgent revascularization, and death. Women are less likely to be urgently diagnosed with acute coronary syndrome, receive thrombolytic therapy, or undergo percutaneous coronary intervention than men, thereby increasing their mortality and morbidity (Bell et al., 1999). There is a need to educate the providers in a rural hospital’s emergency department on the atypical signs and symptoms of acute coronary syndrome in women that present to the ED to facilitate emergent treatment. The objectives of the educational program were to increase provider knowledge about the atypical signs and symptoms of ACS with which women present to the ED as measured by an increase in CORE measures: TNKase in less than 30 minutes from arrival in the ED, number of women who received ASA in the ED, and EKG in less than 10 minutes from arrival at the ED. This capstone project used a one group pretest – posttest quasi-experimental design with a convenience sample of ED providers. The total number of eligible provider participants was 75. Fifty-four (72%) participated in the 39 minute educational intervention and completed both the pre and post-test. There was a 30% increase in provider knowledge from pre to post test, p<0.001. There were 23,385 patients seen in the ED during the intervention time frame. Of those, 1,182 met criteria for inclusion. There was a 52% increase in women who received TNKase in less than 30 minutes from their arrival time in the ED, a 0.8% increase in the number of women who received ASA in the ED and a 4% decrease in obtaining an EKG in less than 10 minutes. The intervention proved to be successful in increasing the knowledge of providers in the recognition of atypical signs and symptoms of ACS, increasing the number of women who received ASA in less than 10 minutes, increasing TNKase administration in less than 30 minutes, and minimally increasing EKG administration. Further follow-up is warranted on the impact of the intervention longitudinally.
Kanser Hastalarına Bakım Veren Aile Üyelerinin Sorunları, Yaşam Kalitesi ve Müdahaleler

Kanser, hem dunyada hem de Turkiye’de olum sebeplerinin basinda gelen, tedavi sureci uzun suren, hasta bakiminin sadece hastanede degil evde de devam ettigi, hastanin oldugu kadar bakim verici olan aile uyelerinin de olumsuz etkilendigi bir hastaliktir. Hastaligi yasayan kisinin etkilenen yasami kadar bakim vermekle yukumlu kisi ve kisilerin de yasamlari fiziksel, duygusal, sosyal ve ekonomik yonden etkilenmektedir. Bakim veren aile uyeleri hem kendi gereksinimleri ve istekleri ile hem de bakim rolunun sorumluluklari arasinda denge kurmaya calismaktadirlar. Bunu yapmaya calisirlarken de yasam kaliteleri bu surecten olumsuz olarak etkilenebilmektedir. Bu derlemede kanser hastasina bakim veren aile uyelerinin yasam kalitelerinin bakim verme surecinden nasil etkilendigi aciklanmaya calisilmis ve bakim verenlere yonelik mudahaleler sunulmustur.
The Use of Low Dose in Radioiodine Ablation of Well-Differentiated ThyroidCancer

Remnant thyroid ablation after thyroidectomy with radioiodine (RAI, I-131) is considered the standard of care for ow risk patients with well-differentiated thyroid cancer (WDTC). The choice of activity for therapy is usually empirically determined according to the tumor characteristics and the patient’s age. Many guidelines recommend a range of 1.1 to 3.7 GBq (30 to 100 mCi), although the choice between the extremes of this range remains controversial. Many studies, including retrospective systematic reviews and randomized multicenter trials, have compared results from using low versus high RAI doses. Data demonstrated similar successful ablation and recurrence rates in these groups, although there are no randomized trials to evaluate long-term outcomes. Until this has been addressed, the choice between 1.1 and 3.7 GBq dose for remnant ablation must be made according to the risk of each patient to maximize the efficacy of treatment, while minimizing unnecessary radiation.
Frequency of Pulmonary Fungal Infection in Egyptian Patients with Re-Treatment Pulmonary Tuberculosis and its Clinical and Radiological Significance

BACKGROUND: Tuberculosis (TB) is the second most common Egyptian health problem after Schistsomiasis. Both TB and pulmonary fungal infections are chronic diseases of immunocompromised hosts. However, the co-association of both illnesses had not well-studied before in Egyptians. Treatment failure of TB, relapse and re-infection are major complications facing both physicians and microbiologists during follow up of tuberculous patients. STUDY AIMS: first, to spot light on the co-association of pulmonary fungal infection and re-treatment pulmonary TB patients, assess its frequency and its radiological findings. Second, to disclose the personal risk factors predisposing to this co-association. METHODS: a two-year prospective cross-sectional study included 258 TB outpatients, 26 were diagnosed as re-treatment pulmonary TB patients and investigated for association of fungal infection microbiologically, clinically and radiologically. Antimycobacterial drug susceptibility testing was done by MGIT 960. RESULTS: Most of re-treatment cases of TB were males in productive age. A statistical significant association between fungal isolation and MDR-TB, re-treatment tuberculous diabetic patients, old age and being a farmer with retreatment TB (P<0.05). Dyspnea and weight loss were the most frequent symptoms in these patients (100%). Histoplasma capsulatum was the most frequently isolated fungus from re-treatment TB cases (37.5%). The most frequent CT findings were bronchiectatic changes. CONCLUSION: Smear examination for fungi is recommended as a routine microbiology investigation for all re-treatment TB cases. Repeated sputum examination is highly recommended for diabetic TB patients, old age patient, farmers searching for retreatment and/or associated fungal infection. HRCT is recommended as low dose radiological modality assessing re-treatment TB cases. (Takwa E. Meawed, Amany Fawzy M, Reda M El Gamry, Amany Shaker, Alaa El Gazzar and Ahmad S. Ragheb (Frequency of Pulmonary Fungal Infection in Egyptian Patients with Re-Treatment Pulmonary Tuberculosis and its Clinical and Radiological Significance) (J Am Sci 2012; 8(5): 683-691). (ISSN: 1545-1003). http://www.americanscience. org. 74
The Effect of Diet, Exercise and Metformin on the Progression of Prostate Cancer

ii ACKNOWLEDGEMENTS . iii CONTENTS . vi LIST OF FIGURES . xi LIST OF TABLES . xiii ABBREVIATIONS . xiv
Neem : A Boon in Medical and Dental Therapies: A review

In traditional medicine most of the diseases have been treated by administration of plant or plant product. Neem, the versatile medicinal plant is the unique source of various compounds. It is considered as a valuable source of unique natural products for development of medicines against various diseases and also for the development of industrial products. Neem, an elegant medicinal plant was found to be the source of various bioactive compounds of medicinal and cosmetic importance. Each part of the neem tree has some medicinal property. This review gives a bird’s eye view mainly on the biological activities of the neem and some of their compounds isolated, pharmacological actions of the neem extracts, and plausible medicinal and dental applications.
CURRENT STANDARDS FOR ASSESSMENT AND DIAGNOSIS OF ALZHEIMER'S DISEASE: A NURSE'S PERSPECTIVE

Clinically, dementia, in particular Alzheimer’s disease (AD), is defined as the progressive decline of memory and other cognitive functions in comparison to the patient’s previous level of function. With 2 sets of criteria for diagnosis, from the American Psychiatric Association and the National Institute of Neurological and Communicative Diseases and Stroke–Alzheimer’s Disease and Related Disorders Association (NINCDS-ADRDA), clinical diagnosis of AD is now 85% to 90% accurate, although the NINCDSADRDA criteria are more detailed and more “user friendly” in a practice setting. Mild cognitive impairment (MCI) is a general term most commonly used to describe a subtle but measurable memory disorder. According to this definition, a person with MCI has memory problems greater than normally expected with aging, but does not show other symptoms of dementia, such as impaired judgment or reasoning. Amnestic MCI is the most common type of MCI (total of 4 types) and appears to be an early manifestation of AD. This article describes the current practice guidelines and recognized criteria for diagnosis of AD and MCI. Two case studies illustrate the nurse’s role and introduce the tools used in screening and diagnosis of these cognitive disorders. (Adv Stud Nurs. 2005;3(6):198-205) D ementia is defined as a general loss of intellectual abilities involving impairment of memory, judgment, and abstract thinking in addition to changes in personality. It does not include delirium (loss of intellectual functioning because of clouded consciousness) or loss of intellectual abilities caused by depression or another psychiatric disorder. Dementia is defined as “an organic mental syndrome” in which potential causes are numerous. Clinically, dementia is defined as the decline of memory and other cognitive functions in comparison to the patient’s previous level of function. Dementias have many different causes, some of which are reversible (eg, adverse medication effects, infections, stroke, and vascular malformation). The dementias share some common characteristics and the challenge is to determine what type and its cause. Alzheimer’s disease (AD) is characterized by progressive memory loss and cognitive decline. Over the past several years, leading medical organizations have published practice guidelines on the diagnosis and management of AD, based primarily on sets of criteria developed by the American Psychiatric Association (in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision, [DSM-IVTR]) and the National Institute of Neurological and Communicative Diseases and Stroke–Alzheimer’s Disease and Related Disorders Association (NINCDSADRDA). AD is primarily a diagnosis of exclusion because AD cannot be definitively diagnosed until autopsy, when the characteristic pathology (plaques and neurofibrillary tangles) can be observed. Although AD may be confused with vascular dementia, clinical diagnosis of AD is now 85% to 90% accurate with these diagnostic criteria. The nurse plays a leading REVIEW
1H NMR spectroscopy combined with principal component analysis for metabonomic study on serum of HBV patients

Objective To characterize the metabolite composition(i.e.,metabonome) of the serum samples from chronic hepatitis B patients by using nuclear magnetic resonance 1H(1H NMR) spectroscopy combined with principal component analysis(PCA). Methods The 1H NMR sepctra were obtained for the serum samples from 8 healthy controls and 20 chronic hepatitis B patients,and the spectra data were analyzed by PCA to demonstrate the metabonomic changes.Results We found that there were evident differences in metabonomics between the healthy controls and chronic hepatitis B patients.The levels of lipids and glucose were significantly increased in the chronic hepatitis B patient and the levels of lactate,alanine,valine,glutamine and phosphocholine/choline were significantly decreased compared with the healthy controls(P0.05). Conclusion Our results indicate that the metabonomes of serum from chronic hepatitis B patients are different from those of the healthy controls.Serum 1H NMR sepctroscopy combined with PCA may offer reliable biochemistry evidence for diagnosis of chronic hepatitis B at molecular level.
Bortezomib (VELCADE®) Plus Dexamethasone as Induction Treatment Prior to Autologous Stem Cell Transplantation in Patients with Newly Diagnosed Multiple Myeloma: Preliminary Results of an IFM Phase II Study.

When patients (pts) with newly diagnosed multiple myeloma (MM) are treated with autologous stem cell transplantation (ASCT), the standard induction therapy is a dexamethasone (Dex) based regimen. Currently, the use of VAD or Dex alone results in a complete remission (CR) rate of Bortezomib is currently approved in the US and in the EU for the treatment of relapsed/refractory MM. Both in vitro studies and preliminary clinical experience in relapsed/refractory pts have suggested that the combination of bortezomib and Dex could further improve the results achieved with bortezomib alone. The IFM group initiated a Phase II open trial assessing the combination of bortezomib and Dex in pts with previously untreated MM and who are candidates for ASCT. The regimen consisted of bortezomib 1.3mg/m² iv on days 1, 4, 8, 11 and Dex 40 mg per os days 1–4, 9–12 (for the first 2 cycles, days 1–4 only for the last 2 cycles), administered on 4 consecutive 21 days cycles. Stem cell collection was performed just before cycle 4 after G-CSF priming. The primary objective of the study was CR rate after 4 cycles. As of August 1, 47 pts have been recruited and data is available for the first 18 pts. The median age is 53 years (38–63) Sixteen / 18 pts received 4 cycles: 1 patient progressed after 3 cycles and in one case the last two injections of bortezomib were not performed because of grade 3 neuropathy. The overall results were as follows: CR (negative electrophoresis) 3; very good partial remission (90% reduction of M component) 2; partial remission (50% reduction of the serum M component or 90% reduction of the urine M component) 10; failure (stable disease or progression ) 3. The overall response rate was 83% and the CR rate was 17%. Side effect were usually mild (grade 1/2); only one grade 3 neuropathy was recorded. In all cases stem cells could be adequately collected. These preliminary results appear to be very encouraging and the bortezomib / Dex combination appears effective and well tolerated in pts with newly diagnosed MM. The results will be updated at time of presentation. If updated analysis confirms currently available data, the IFM will start a large randomized phase III trial comparing VAD and bortezomib / Dex as induction treatment prior to ASCT in pts with newly diagnosed MM up to the age of 65.
Incidence of Diabetes Mellitus in Patients with Lichenplanus

Aims: To find out the incidence of diabetes mellitus in patients with oral lichen planus (OLP). Materials and Methods: Experimental group consists of 50 OLP subjects and control group comprised of 10 subjects. Incisional biopsy from the lesion site was obtained for experimental subjects and normal oral mucosa in the third molar region was used as biopsy specimen for control subjects. Oral glucose tolerance test (OGTT) was done for all the subjects and results were tabulated and subjected to t test for analysis. Results: The OGTT for control group in fasting level, 1 and 2 hours after glucose administration were within the physiological limits in males and females. Among the 50 OLP subjects 5 (10%) were diabetic in the age range of 42-40 with a mean of 56.5 years. The results are statistically highly significant with P value of <0.001 for FBS, 1 hour and 2 hour samples when OGTT values in OLP diabetics v/s controls are compared.
Potential Therapeutic Approaches for Stroke Using Induced Pluripotent Stem Cells

Stroke is a principal cause of mortality in most countries and up to date there is no cure or potential therapeutic treatment available for this debilitating condition. Human induced pluripotent stem (hiPS) cells are an important source for autologous cells used in regenerative medicine in order to treat brain damage after a stroke has occurred. Recent studies have suggested that transplanted neural cells derived from hiPS cells have the potential to survive, differentiate and improve motor behavior in stroke animal models. In this review, we discuss the conditions needed to reprogram hiPS cells for clinical trials, the strategies used to differentiate hiPS cells toward neural stem cells (NSC) lineage along with their functionality and morphological characteristics studied in vitro. We further address the features founded in vivo after graft transplantation of these neural cells into stroke animal models.
The role of CFTR in normal human lung microvascular endothelial cells

I Declaration . II Dedication: . III Quotes: . IV Acknowledgments . V Content . Error! Bookmark not defined. List of Figures . XII List of tables . XVI Abbreviations . XVII Chapter One . 1 General Introduction. 1 1.1 Human Lung Microvascular Endothelial cells: . 1 1.1.1 Vascular endothelium role in regulating vascular tone: . 2 1.1.2 Vascular endothelium role in regulating haemostasis:. 3 1.1. 3 Vascular endothelium role in inflammation: . 4 1.1. 4 Vascular endothelium role in regulating angiogenesis: . 6 1.1. 5 Vascular endothelium response to shear stress: . 7 1.1. 6 Vascular endothelium and oxidative stress: . 8 1.2 Role of CFTR in cystic fibrosis: . 9 1.2.1 The irregularity in CFTR protein expression and function in CF . 10 1.2.2 Cystic fibrosis therapies . 11 1.2.3 Hypothesis, aims and objectives: . 12 Chapter Two . 13 Materials and Methods . 13 2.1 Human Lung Microvascular Endothelial cells: . 13 2.1.1 Seeding HLMVECs: . 14 2.1.2 Passaging HLMVECs: . 14 2.1. 3 Subculturing HLMVEC: . 14 2.1. 4 Cryopreservation of cells: . 15 2.2 Coating plates and chamber slides with collagen IV:. 15 2.3 Processing samples: . 16 2.3. 1 Supernatant: . 16 2.3. 2 Cells: . 16 2.4 Western blotting: . 17
Supporting caregivers of people with Amyotrophic Lateral Sclerosis

Informal caregivers play a crucial role in the care for people with Amyotrophic Lateral Sclerosis (ALS). ALS is a motor neuron disease which leads to muscle weakness and respiratory failure. During the disease course patients become more and more dependent on their environment. The majority of care tasks are provided by informal caregivers such as partners or children. Research shows that these caregivers often experience feelings of psychological distress or caregiver burden, but there is a lack of supportive interventions for these caregivers. The overall aim of this theses is to improve the support for caregivers of people with ALS. In this study a support program for caregivers of people with ALS was developed and evaluated on its effectiveness. The aim of the support program was to increase the feeling of control over caregiving in order to decrease feelings of psychological distress. The support program was based on Acceptance and Commitment Therapy and consisted of one face-to-face contact, 6 online guided modules and one telephone call. Although caregivers evaluated the program positively, no effects on psychological distress were found. A positive intervention effect was found on caregivers ability to control upsetting thoughts related to caregiving. Caregivers reported that the program helped them to become more aware of their own situation, perceive control over their situation, accept negative emotions and thoughts, to be there for their partner and to feel acknowledged in their role. The support program will be adapted in line with the received feedback from caregivers and can be considered as one of the support options available for caregivers of people with ALS.
Dyslipidemia in Newfoundland: findings from Canadian primary care sentinel surveillance network in Newfoundland and Labrador

Newfoundland and Labrador (NL) has a higher level of cardiovascular disease (CVD) mortality than any other Canadian province. One factor which may explain this trend is the lipid profile pattern in this province. Given the limited lipid profile data which has been reported from NL, we organized three studies in this thesis to describe the lipid profile of Newfoundlanders. The first study was a secondary analysis of Canadian Primary Care Sentinel Surveillance Network (CPCSSN) data to document single and mixed dyslipidemia in NL. The second study compared lipid profiles and the prevalence of dyslipidemia between NL CPCSSN data and the Canadian Health Measures Survey (CHMS). The third study used electronic medical record (EMR) data in assessing the validity of ICD codes for identifying patients with dyslipidemia. This was a secondary analysis of EMR data in NL. Most recent lipid profile scores, co-morbidities, and demographic information were extracted from the CPCSSN database. We demonstrated that single and mixed dyslipidemia are quite prevalent in the NL population. Unhealthy levels of HDL were also more prevalent in NL men, compared to the Canadian sample. Of importance, the use of the ICD coding, either alone or in combination with laboratory data or lipid-lowering medication records, was an inaccurate indicator in identifying dyslipidemia.