Miracle-dz/UniFAR-FTUs huggingface dataset:
Toward Modern Classification of Eustigmatophytes, Including the Description of Neomonodaceae Fam. Nov. and Three New Genera1

The class Eustigmatophyceae includes mostly coccoid, freshwater algae, although some genera are common in terrestrial habitats and two are primarily marine. The formal classification of the class, developed decades ago, does not fit the diversity and phylogeny of the group as presently known and is in urgent need of revision. This study concerns a clade informally known as the Pseudellipsoidion group of the order Eustigmatales, which was initially known to comprise seven strains with oval to ellipsoidal cells, some bearing a stipe. We examined those strains as well as 10 new ones and obtained 18S rDNA and rbcL gene sequences. The results from phylogenetic analyses of the sequence data were integrated with morphological data of vegetative and motile cells. Monophyly of the Pseudellipsoidion group is supported in both 18S rDNA and rbcL trees. The group is formalized as the new family Neomonodaceae comprising, in addition to Pseudellipsoidion, three newly erected genera. By establishing Neomonodus gen. nov. (with type species Neomonodus ovalis comb. nov.), we finally resolve the intricate taxonomic history of a species originally described as Monodus ovalis and later moved to the genera Characiopsis and Pseudocharaciopsis. Characiopsiella gen. nov. (with the type species Characiopsiella minima comb. nov.) and Munda gen. nov. (with the type species Munda aquilonaris) are established to accommodate additional representatives of the polyphyletic genus Characiopsis. A morphological feature common to all examined Neomonodaceae is the absence of a pyrenoid in the chloroplasts, which discriminates them from other morphologically similar yet unrelated eustigmatophytes (including other Characiopsis‐like species).
Benefits of heterospecific aggregation on necromass: influence of temperature, group density, and composition on fitness‐related traits

Necrophagous blowflies (Diptera: Calliphoridae) such as Calliphora vicina, a cold‐tolerant species, and Lucilia sericata, a warm‐adapted species, are pioneer carrion‐breeder. Although these two species have different temperature preferences, larvae aggregate actively and often feed simultaneously on carrion. The hypothesis to be tested was that L. sericata benefits from the association with C. vicina at lower temperatures (i.e., 15 °C) and that C. vicina derives greater benefits from this association at higher temperatures (i.e., 28 °C).
Role of new antibiotics in the treatment of acute bacterial skin and skin-structure infections.

PURPOSE OF REVIEW To summarize the available efficacy and safety data of novel agents for treating acute bacterial skin and skin-structure infections (ABSSSI), focusing on those active against methicillin-resistant Staphylococcus aureus (MRSA). RECENT FINDINGS There are now several agents active against MRSA that are approved for the treatment of ABSSSI, including tedizolid, ceftaroline, dalbavancin, telavancin, oritavancin, delafloxacin, and omadacycline. In addition, iclaprim has completed phase-3 randomized clinical trials (RCTs). SUMMARY Considering the similar efficacy that arose from direct comparisons in phase-3 RCTs, in order to adopt the best approach for treating ABSSSI on patient-tailored basis, the different safety profiles and formulations of the different available agents should be balanced by taking into account the specific features of each treated patient in terms of baseline comorbidities, related risk of toxicity, need for hospitalization, possibility of early discharge, and expected adherence to outpatient oral therapy.
Correlation of serum protein biomarkers with disease activity in psoriatic arthritis

ABSTRACT Objective: To assess the correlation of serum protein biomarkers with disease activity across different domains of psoriatic arthritis (PsA). Material and methods: A cross-sectional cohort of 45 adult patients with PsA fulfilling the classification for psoriatic arthritis (CASPAR) criteria was recruited from University of California San Diego (UCSD) Arthritis Clinics. Clinical data and serum samples were collected and serum was analyzed for protein biomarkers hypothesized to be relevant to disease activity in PsA. Correlations were evaluated for clinical disease activity measures across disease domains. Results: Biomarkers with the highest correlation to the composite indices and disease domains were SAA, IL-6, YKL-40, and ICAM-1. In addition, several biomarkers were moderately correlated with individual composite indices and/or disease domains. Low or no correlation was observed with some biomarkers, e.g. MMP-3, MMP-1, EGF, VEGF, and IL-6R. In contrast, the correlation of all biomarkers with certain disease domains was low; specifically, pain, percent body surface area of psoriasis, and patient global assessment. The multi-biomarker disease activity score (MBDA) developed for rheumatoid arthritis (RA) showed high correlations with most composite indices and some disease domains in PsA. Conclusions: These data suggest biomarker analysis can reflect disease activity across disease domains in PsA. Certain domains would likely benefit from the evaluation of additional biomarkers.
Worldwide implementation of clinical services for the prevention of psychosis: The IEPA early intervention in mental health survey

Clinical research into the Clinical High Risk state for Psychosis (CHR‐P) has allowed primary indicated prevention in psychiatry to improve outcomes of psychotic disorders. The strategic component of this approach is the implementation of clinical services to detect and take care of CHR‐P individuals, which are recommended by several guidelines. The actual level of implementation of CHR‐P services worldwide is not completely clear.
The Use of Sex-Specific Factors in the Assessment of Women’s Cardiovascular Risk

Cardiovascular disease (CVD) is the leading cause of death among women in the United States. As compared with men, women are less likely to be diagnosed appropriately, receive preventive care, or be treated aggressively for CVD. Sex differences between men and women have allowed for the identification of CVD risk factors and risk markers that are unique to women. The 2018 American Heart Association/American College of Cardiology Multi-Society cholesterol guideline and 2019 American College of Cardiology/American Heart Association guideline on the primary prevention of CVD introduced the concept of risk-enhancing factors that are specific to women and are associated with an increased risk of incident atherosclerotic CVD in women. These factors, if present, would favor more intensified lifestyle interventions and consideration of initiation or intensification of statin therapy for primary prevention to mitigate the increased risk. In this primer, we highlight sex-specific CVD risk factors in women, stress the importance of eliciting a thorough obstetrical and gynecological history during cardiovascular risk assessment, and provide a framework for how to initiate appropriate preventive measures when sex-specific risk factors are present.
Phenolic Profiles of Hardy Kiwifruits and Their Neuroprotective Effects on PC-12 and SH-SY5Y Cells against Oxidative Stress

Hardy kiwifruits (Actinidia arguta Planch.) have high amounts of antioxidants, including ascorbic acid (vitamin C) and phenolics. The anti-cholinesterase activity and neuroprotective effects of three different cultivars of hardy kiwifruits, cv. Mansu (A. arguta × A. deliciosa), cv. Haeyeon (A. arguta), and cv. Chiak (A. arguta), on PC-12 and SH-SY5Y cells were evaluated. Extraction of phenolics and vitamin C was carried out using 80% (v/v) aqueous ethanol and metaphosphoric acid assisted with homogenization, respectively. Hardy kiwifruit of cv. Mansu showed higher total phenolic, total flavonoid, and vitamin C content and antioxidant capacity compared to the other two cultivars of hardy kiwifruits, cv. Haeyeon and cv. Chiak. Analysis of high-performance liquid chromatography results revealed the presence of procyanidin B2, (−)-epicatechin, neochlorogenic acid, cryptochlorogenic acid, rutin, hyperoside, isoquercitrin, and astragal in hardy kiwifruits. The three cultivars of hardy kiwifruits had a wide range of vitamin C content of 55.2−130.0 mg/100 g fresh weight. All three cultivars of hardy kiwifruits had protective effects on neuronal PC-12 and SH-SY5Y cells exposed to hydrogen peroxide by increasing cell viability and reducing intracellular oxidative stress. Furthermore, the hardy kiwifruits inhibited acetylcholinesterase and butyrylcholinesterase. Collectively, these results suggest that hardy kiwifruits rich in antioxidants like phenolics and vitamin C have good potential as functional materials in neuroprotective applications.
Effect of Probiotic Clostridium butyricum NCTC 7423 Supernatant on Biofilm Formation and Gene Expression of Bacteroides fragilis

Enterotoxigenic Bacteroides fragilis (ETBF) is the main pathogen causing severe inflammatory diseases and colorectal cancer. Its biofilm plays a key role in the development of colorectal cancer. The objective of this study was to determine the antagonistic effects of cell-free supernatants (CFS) derived from Clostridium butyricum against the growth and biofilm of ETBF. Our data showed that C. butyricum CFS inhibited the growth of B. fragilis in planktonic culture. In addition, C. butyricum CFS exhibited an antibiofilm effect by inhibiting biofilm development, disassembling preformed biofilms and reducing the metabolic activity of cells in biofilms. Using confocal laser scanning microscopy, we found that C. butyricum CFS significantly suppressed the proteins and extracellular nucleic acids among the basic biofilm components. Furthermore, C. butyricum CFS significantly downregulated the expression of virulence- and efflux pump-related genes including ompA and bmeB3 in B. fragilis. Our findings suggest that C. butyricum can be used as biotherapeutic agent by inhibiting the growth and biofilm of ETBF.
Longitudinal Effects of Cognitive and Affective Empathy on Adolescent Substance Use

Abstract Background: A deficit in either socio-cognitive or socio-affective components of empathy is associated with the severity of substance use by late adolescence. What remains unknown is how longitudinal changes in these components of empathy predict adolescent substance using behavior. Methods: This secondary data analysis used data that followed adolescents in outpatient treatment for substance use (n = 826) during treatment and at 6 months post-treatment. To examine cross-lagged effects of empathy on substance use over time, we used a latent basis growth curve model. Results: Increases in affective empathy predicted reduced substance use over time. However, cognitive empathy did not predict substance use after controlling for other covariates. Conclusions: Lower levels of affective empathy may indicate a developmental vulnerability for substance using behavior. Modifying affective empathy may be a viable treatment target for reducing adolescent substance use.
INGRESS: Interactive visual grounding of referring expressions

This article presents INGRESS, a robot system that follows human natural language instructions to pick and place everyday objects. The key question here is to ground referring expressions: understand expressions about objects and their relationships from image and natural language inputs. INGRESS allows unconstrained object categories and rich language expressions. Further, it asks questions to clarify ambiguous referring expressions interactively. To achieve these, we take the approach of grounding by generation and propose a two-stage neural-network model for grounding. The first stage uses a neural network to generate visual descriptions of objects, compares them with the input language expressions, and identifies a set of candidate objects. The second stage uses another neural network to examine all pairwise relations between the candidates and infers the most likely referred objects. The same neural networks are used for both grounding and question generation for disambiguation. Experiments show that INGRESS outperformed a state-of-the-art method on the RefCOCO dataset and in robot experiments with humans. The INGRESS source code is available at https://github.com/MohitShridhar/ingress.
“You have to be clean:” a qualitative study of pubic hair grooming behaviours among women living in Italy

Abstract The majority of pubic hair and genital self-image research describes women living in the USA, UK and Australia. This may leave attitudes and behaviours across other cultures and geographic regions ambiguous. The purpose of this study was to describe pubic hair removal attitudes and behaviours among reproductive-age women living in Italy. Individual interviews were conducted with 46 women aged 18-45 years between June and July 2017, living in Florence, Italy and currently utilising the Italian healthcare system. Pubic hair removal was popular among participants. Women mainly removed pubic hair by waxing. Sexual partners influenced removal, as did cultural norms and the desire for cleanliness. Most participants indicated pubic hair removal onset during adolescence, often upon puberty. However, most participants had never discussed removal complications with providers. Pubic hair removal often related to a more positive genital self-image because of social norms surrounding hairlessness. Removal among this sample appears to differ from the literature in other contexts, with women living in Italy engaging in more frequent and earlier waxing. Findings offer opportunities for clinicians to proactively address safe pubic hair practices and women’s genital concerns during consultations.
Below-the-Ankle Arrival Time as a Novel Limb Tissue Perfusion Index: Two-dimensional Perfusion Angiography Evaluation

Purpose: To identify lower limb 2-dimensional (2D) perfusion angiographic parameters that are related to skin perfusion pressure (SPP), a predictor of wound healing in patients with chronic limb-threatening ischemia (CLTI) undergoing below-the-knee (BTK) endovascular treatment (EVT). Materials and Methods: Thirty-three consecutive patients (mean age 74.5 years; 18 men) with 47 isolated BTK lesions in 33 limbs (Rutherford category 3–5) underwent EVT. Dorsal and plantar SPPs were measured before EVT and the day after. The indexed blood flow below the ankle was measured using 2D perfusion angiography before and after EVT to determine changes in perfusion parameters [arrival time (AT), time to peak, wash-in rate, mean transit time, and width and area under the time-density curve] at rest vs during hyperemia induced with a 20-mg intra-arterial papaverine infusion. Correlations between the 2D perfusion parameters and SPPs were assessed using the Pearson coefficient. The cutoff points to predict mean SPPs >40 mm Hg were analyzed using a receiver operating characteristic curve; outcomes are reported as the area under the curve (AUC) with 95% confidence interval (CI). Results: After EVT at rest and during hyperemia, only AT was significantly changed, although hyperemia produced significant changes in all the pre-/post-EVT 2D perfusion parameters except the wash-in rate. Dorsal and plantar SPPs after EVT were significantly increased and correlated with hyperemic AT and the AT ratio (hyperemia/at rest values) below the ankle. Hyperemic ATs <6.3 seconds and AT ratios <0.78 were predictive factors for a mean SPP >40 mm Hg, with AUCs of 0.83 (95% CI 0.67 to 0.99) and 0.78 (95% CI 0.61 to 0.95), respectively. Conclusion: Hyperemic ATs <6.3 seconds or AT ratios <0.78 below the ankle may be essential to obtain sufficient SPPs for limb salvage in BTK lesions. Thus, the use of 2D perfusion angiography enabled the monitoring of lower limb tissue perfusion throughout EVT and may thereby optimize treatment of CLTI.
Comparative effectiveness research applied to medical devices: Which PFO closure device is the best?

• Device-to-device comparisons are of interest and of potential practical value for clinicians. • The study design to achieve a high level of scientific evidence requires a prospective, multicenter, randomized trial with a large number of patients and addressing all important outcomes related to device effectiveness and safety. • The study by Fleming and coauthors comparing six different devices is provocative and interesting and has several virtues, but does not meet most of these standards, so readers should be cautious in deciding their device preferences.
Achieving healthy ageing through the perspective of sense of coherence among senior-only households: a qualitative study

Abstract Objectives: Explore perceptions towards healthy ageing through the perspective of sense of coherence among older adults residing in senior-only households. Methods: A qualitative study using focus group interviews was conducted and appreciative inquiry was adopted as a strengths-based interviewing approach. 27 older adults who either live alone or with their spouses only were involved in six focus group discussions at a community centre in Singapore. Data saturation was achieved and thematic analysis was performed to analyse the data. Results: The four emerging themes were (1) contending evolving vulnerabilities, (2) intrinsic value of health, (3) taking care of oneself is a personal responsibility, and (4) taking one day at a time: outlook towards later part of life. Older adults’ underlying pathogenic orientation towards health contributed to their perceived unpredictable confrontations with vicissitudes including illness and death. This played a part to their short outlook towards old age. Consequently, this could limit their will and abilities to seek meaningful pursuits or valued aspirations and movement towards the salutogenic health pole. Conclusion: By reframing the definition of health to pursuing and fulfilling valued accomplishments, optimal health can be achieved regardless of physical health state. This study suggested that sense of coherence towards the pursuit of healthy ageing can be addressed by reducing the unpredictability of ageing-related processes and vulnerabilities (comprehensibility), supporting active adoption of actions which promotes physical, mental and social health (manageability) and individual reflection in making sense of old age to seek motivation in living each day purposefully (meaningfulness).
Effect of Cation on Efficiency of Aspegillus flavus Bioflocculant Produced from Chicken Viscera Hydrolysate

<p class="0abstract"><strong>Abstract—</strong> The cations are needed as stimulants for effective flocculation by the cation-dependent bioflocculants. Addition of metal ions (cations) can counterbalance anionic functional groups of both bioflocculant and solid particles thereby increasing the bioflocculant adsorption to suspended particles. In the present study, addition of all dose of both Ca<sup>2+</sup> and Mg<sup>2+</sup> stimulated the efficiency of the bioflocculant with optimum flocculation efficiency of 95% recorded with 5 mL of 1% Ca<sup>2+</sup><sub>. </sub>While lower dose (1 – 2 mL) of Al<sup>3+</sup> also stimulated the bioflocculant to about 94%, Na<sup>+</sup> and Fe<sup>3+</sup> inhibited flocculation at all doses tested. K<sup>+</sup> slightlyenhanced the flocculation at 4 - 10mL of 1%. The present cationic bioflocculant can be suggested as a substitute for chemical flocculants. </p>
GAUGED FLOER HOMOLOGY FOR HAMILTONIAN ISOTOPIES I: DEFINITION OF THE FLOER HOMOLOGY GROUPS

We construct the vortex Floer homology group V HF (M,μ;H) for an aspherical Hamiltonian G-manifold (M,ω) with moment map μ and a class of G-invariant Hamiltonian loop Ht, following the proposal of [3]. This is a substitute for the ordinary Hamiltonian Floer homology of the symplectic quotient of M . We achieve the transversality of the moduli space by the classical perturbation argument instead of the virtual technique, so the homology can be defined over Z or Z2.
Signal and reward in wild fleshy fruits: Does fruit scent predict nutrient content?

Abstract Plant species with fleshy fruits offer animals rewards such as sugar, protein, and fat, to feed on their fruits and disperse their seeds. They have also evolved visual and olfactory signals indicating their presence and ripeness. In some systems, fruit color serves as a reliable visual signal of nutrient content. Yet even though many volatile chemicals used as olfactory signals derive from nutrients animals seek, it is still unknown whether fruit scent encodes information regarding nutrient content in wild fruits. We examine the relationship between olfactory signals and nutrient rewards in 28 fruiting plant species in Madagascar. We measured the relative amounts of four chemical classes in fruit scent using gas chromatography and mass spectrometry, as well as the relative amounts of sugar and protein in fruit pulp. We found that protein levels are not associated with elevated amounts of chemically related volatile compounds in fruit scent. In contrast, sugar content is strongly associated with the chemical composition of fruit scent. To our knowledge, this is the first research to explore the connection between fruit chemical signals and nutrient rewards. Our results imply that in the case of sugar, fruit scent is predictive of nutrient content and hence an honest signal.
Evaluating the Effectiveness of Using the Protection and Security of Information Systems in the National Organizations of Information Security

All organizations, staffs, foundations and universities in this age depend completely on information and data to convoy the technical and scientifically development, and as it's known today that this age we live in is called or known as the age of information or the age of technology , and we can say that having a greater amount of information means having control over several fields and the development of information systems has already done a huge qualitative leap in the field of information technology , it's preciseness , increasing it's productivity and exploiting machines for performing all works in foundations and some other organizations ,therefore foundations started aiming to get the biggest amount of information, thence negativity appeared in technology and penetration, piracy and data exchange in illegal way started to be called ; information technology crimes, as it is a phenomenon which has many effects over the political, martial, economical, and safety fields , therefore foundations, universities, organizations, information centers and some other administrations should protect their information and data from penetrating networks and information systems where they exchange these information and process them ,whether inside that foundation / center or through the world wide web. Among these foundations which depend on information; research centers, information centers , universities , libraries and some other different foundations which have an informational uprising that should have been protected from piracy and theft . This study ought to evaluate the reality of using security and protection of information systems in the national organization of information security from stealing , penetration , messing up, robbery , or change which effects directly on the credibility of this foundation considering information and data the spinal column of this foundation .
Beating the Odds: Arbitrage and Wining Strategies in the Football Betting Market

We examine the potential for generating positive returns from wagering on football matches. To this end, arbitrage and a simple betting strategy based on a logit regression forecasting model are employed. The analysis suggests that the differences in the odds quoted by bookmakers can lead to profitable arbitrage opportunities. We show that a betting strategy based solely on the information embedded in the bookmakers’ odds can yield positive expected return. This fact undermines the validity of the efficient markets hypothesis for the football betting market.