Miracle-dz/UniFAR-FTUs huggingface dataset:
ActivationMicroRNA-125b Potentiates Macrophage

MicroRNA (miR)-125b expression is modulated in macrophages in response to stimulatory cues. In this study, we report a functional role of miR-125b in macrophages. We found that miR-125b is enriched in macrophages compared with lymphoid cells and whole immune tissues. Enforced expression of miR-125b drives macrophages to adapt an activated morphology that is accompanied by increased costimulatory factor expression and elevated responsiveness to IFN- g , whereas anti–miR-125b treatment decreases CD80 surface expression. To determine whether these alterations in cell signaling, gene expression, and morphology have functional consequences, we examined the ability of macrophages with enhanced miR-125b expression to present Ags and found that they better stimulate T cell activation than control macrophages. Further indicating increased function, these macrophages were more effective at killing EL4 tumor cells in vitro and in vivo. Moreover, miR-125b repressed IFN regulatory factor 4 (IRF4), and IRF4 knockdown in macrophages mimicked the miR-125b overexpression phenotype. In summary, our evidence suggests that miR-125b is at least partly responsible for generating the activated nature of macrophages, at least partially by reducing IRF4 levels, and potentiates the functional role of macrophages in inducing immune responses. The Journal of Immunology , 2011, 187: 5062–5068.
Mobile telephone-based remote orthopedic consultation.

AJR 2010; 195:W307 0361–803X/10/1954–W307 © American Roentgen Ray Society Mobile Telephone–Based Remote Orthopedic Consultation We very much enjoyed reading the article by Toomey et al. [1] in the February 2010 issue of the AJR, and we would like to share our success story with mobile telephone– based remote orthopedic consultation. TEREM Emergency Medical Centers is a medical services company that operates five urgent care facilities in the greater Jerusalem area. In 2009, we managed 200,000 urgent care visits, including nearly 10,000 fractures and 30,000 nonfracture traumas. Our clinics all have digital, on-site, computerized radiology during all operating hours. Our consultants carry smartphones with the capability of receiving and viewing radiographic images via a custom-developed Web page directly from our proprietary electronic medical record system. To initially validate our system, a sample of 41 images with both gross and subtle findings was viewed by an orthopedist on a mobile device. The reports of the orthopedic consultant were compared with the readings of our radiologists who read the same images via our regular PACS using diagnostic screens. All findings, both subtle and gross, were identified by both the orthopedist and the reporting radiologist. We published these findings in the Israeli Journal of Emergency Medicine [2]. Since the implementation of this system, we have had an additional 312 orthopedic radiology studies that have been initially reviewed by mobile telephone and then confirmed later via radiologist review. To date, no clinically significant fracture has been missed using the mobile device. Of special note is that since inception of this remote consultation system, we have seen a drop of nearly 50% in referrals from our clinics to the hospital. In many cases, the remote consultant was able to provide advice on local clinic management, thus saving the referral to the hospital emergency department. In summary, we have a great deal of clinical evidence that remote access to imaging can be a timeand money-saving tool for many practices. It has been shown to reduce the number of unnecessary hospital referrals and can lead to increased comfort of clinic physicians from knowing that they have received subspecialty input regarding the proper care and follow-up for their patients. Rachel Hammel Nahum Kovalski Deena R. Zimmerman TEREM Emergency Medical Centers D.N. Shimshon, Israel
Knowledge Transfer and Quality Practices in the Implementation of a Sourcing Capability Model

This study adopts a knowledge transfer framework to examine the implementation and assimilation of a process improvement program for outsourcing service providers. Our theoretical model identifies the factors affecting knowledge transfer during both the initial implementation stage and the subsequent stage of full assimilation of improved outsourcing processes into organizational practice. We evaluate our theoretical model using detailed archival data collected on the implementation of an outsourcing capability model in the offshore delivery center of a large service provider. Findings indicate that knowledge transfer characteristics affect the time to implement the improved processes in the delivery center, but do not significantly relate to the likelihood of full assimilation. We also find an unexpected curvilinear relationship between implementation time and assimilation success such that processes with very low or very high implementation times are more likely to be fully assimilated.
DiviVis : Exploration into Socio-Economic Factors that Can Potentially Affect Individual Internet Use with Visualization

This design study (problem driven programming project) provides illustrations and graphs, which enable us to compare a few social and economic factors with Internet use on a world scale. Through this hypothesis generation process, we aimed to provide a visualization tool for the user who is interested in the investigation of multiple social and economic indicators in relation to the rate of Internet usage in the world in order to find possible relationships between Internet use and geographic boundaries: Are there specific relations or differences between the concentration of Internet use among geographic boundaries including multiple continents or regions? By using visualizations that show the increase or decrease in Internet use over the terms of the seven years from 2008 to 2014, can we identify which social or economic factors from the list selected show potential related effects on the growth and increased demand. To address these questions, we took multiple steps and developed different visualization tools to enable the user to test and compare social and economic factors in relation to the Internet usage for up to 6 countries and target specific patterns or relationships between factors and the rate of Internet use.
Empowering Refugees with Technology: Best Practices and Research Agenda

Recommended Citation AbuJarour, Safa'a; Krasnova, Hanna; Diaz Andrade, Antonio; Olbrich, Sebastian; Tan, Chee-Wee; Urquhart, Cathy; and Wiesche, Manuel, (2017). "EMPOWERING REFUGEES WITH TECHNOLOGY: BEST PRACTICES AND RESEARCH AGENDA". In Proceedings of the 25th European Conference on Information Systems (ECIS), Guimarães, Portugal, June 5-10, 2017 (pp. 3263-3273). ISBN 978-0-9915567-0-0 Panels. https://aisel.aisnet. org/ecis2017_panels/4
Monte Carlo Design Space Exploration of Superconducting Wind Generator Using MgB2 and YBCO Conductors

Considering the global outcry over climate change and the need for increased penetration of clean forms of energy in ever-increasing aspects of the modern economic sphere, wind power installations, particularly offshore, are expected to rise in the next decades. However, the main obstacle to this trend will be represented by the high installation costs. In order to reduce these costs, the wind turbines generators require to be manufactured to yield higher torque density with lower material input in terms of weight. One way to pursue this requirement is to employ high-temperature superconductor (HTS) technology for the rotor windings and/or the stator windings, making it possible to design cheaper generators for 10-MW applications. This work considers the impact of HTS conductors in wind turbine generators to complement material research work at the University of Houston HTS material research work. Four topologies of generators were investigated: two partially superconducting generators employing YBCO and MgB2 as conductor for the rotor windings and two fully superconducting generators employing MgB2. The electromagnetic physics governing the machine was simulated by finite-element analysis software, i.e., FlexPDE; then, a numerical analysis of thousands of models was realized by Python. An exploration of the results was carried out making use of an optimum criterion considering a simple aggregation of the generator mass active, the copper, ac stator windings losses, and the amount of superconductor needed. Trends of these optimization criteria with reference to design parameters are shown in detailed plots. According to the specific aims of the designer, the investigation provided interesting clues regarding, among others, the number of pair of poles and the amount of superconductor employed characterizing the best models.
Intrathecal anaesthesia in patients under 45 years: incidence of postdural puncture symptoms after spinal anaesthesia with 27G needles

Postoperative headache and backpain has limited the use of intrathecal anaesthesia in younger patients (15–45 years). We studied postoperative complaints among 133 healthy young patients (mean age 30.0 years, 47% females) who received spinal anaesthesia with a 27G needle. Postoperatively, 5 patients (4%) complained of postdural puncture headache (PDPH), 18 (14%) reported nonspecific headache, while 27 (20%) suffered from backpain. PDPH was not related to sex, age, day‐care surgery, number of puncture attempts, or obstetric procedures. Backpain was significantly more common among females, and among in‐patients. One hundred and sixteen patients (87%) would accept spinal anaesthesia if they were to undergo the same surgical procedure again. Compared to other studies, we find the incidence of postanaesthetic complaints to be acceptable, also among day‐care patients. The PDPH seemed to be lightly incapacitating, and only one patient required blood patching.
Community detection in networks: Modularity optimization and maximum likelihood are equivalent

We demonstrate an equivalence between two widely used methods of community detection in networks, the method of modularity maximization and the method of maximum likelihood applied to the degree-corrected stochastic block model. Specifically, we show an exact equivalence between maximization of the generalized modularity that includes a resolution parameter and the special case of the block model known as the planted partition model, in which all communities in a network are assumed to have statistically similar properties. Among other things, this equivalence provides a mathematically principled derivation of the modularity function, clarifies the conditions and assumptions of its use, and gives an explicit formula for the optimal value of the resolution parameter.
A simplified adaptive scheduling algorithm for increased throughput guarantees

Offering throughput guarantees for wireless networks is of interest to both the network operators and the customers. In this paper, an optimization problem is formulated which aims at maximizing the throughput that can be guaranteed to the mobile users. Solution to this problem has already been found for users with different channel quality distributions. However, this solution is suboptimal for time-windows containing only a small amount of time-slots. Hassel et al. proposed an adaptive scheduling algorithm that showed good performance for short time-windows but that algorithm can only fulfill the throughput guarantees when the placement of the window is fixed and cannot promise the throughput guarantees within time-windows with a different duration or a different placement than that used by the algorithm. In this work, we propose a very simple adaptive scheduling algorithm that overcomes the problem of fixed window placement and provides similar throughput guarantees. Our simplified adaptive algorithm also performs significantly better than other well-known scheduling algorithms.
A palliative care hotline for multiple sclerosis: A pilot feasibility study

Abstract Objective: Research findings suggest that patients severely affected by multiple sclerosis benefit from palliative care. Our objectives were to (1) implement a pilot palliative care counseling hotline for severely affected multiple sclerosis patients and their caregivers in order to connect them to palliative care, and (2) evaluate its preliminary feasibility through a pilot study. Method: The hotline was designed in cooperation with the local state association of the German Multiple Sclerosis Society and based on a review of the literature. The initial study setting for the hotline was the broader region of the cities Cologne and Bonn in Germany. The hotline was introduced through a magazine published by the German Multiple Sclerosis Society and leaflets sent to local healthcare providers. Calls were conducted using a semistructured interview guide and documented by a standardized case report form. Measures to assess feasibility were both quantitative (e.g., number of calls) and qualitative (e.g., criteria for eligibility for palliative care). Results: During its pilot year, the hotline received 18 calls. Some 15 callers were included in the analysis, and 10 of these 15 were deemed eligible for palliative care due to such criteria as medical characteristics, care or nursing conditions, caregiver strain, and concerns regarding death and dying. Access to palliative care services could be provided for all 10 callers. Significance of results: Based on our pilot feasibility study, the hotline seems to be a valuable service for patients severely affected by multiple sclerosis (MS) and their caregivers in order to gain information about and access to palliative care. It will be extended on a nationwide scale through a grant of the German Multiple Sclerosis Society. Awareness of the hotline needs to be enhanced in order to attract and support a significant number of new callers.
A broadband highly linear 3.5-6GHz CMOS VCO for multi-standard wireless transceivers

A broadband highly linear Voltage controlled oscillator (VCO) for multi-standard wireless transceivers application is presented in this paper. Highly linear VCO gain (Kvco) is exhibited in the VCO which can realize a linear Kvco, better phase noise performance and more stable oscillation in same time. A 6-bit switched capacitor array is employed to extend the tuning range, and also 6-bit switched current source to guarantee robust start-up condition and maintain the amplitude of different frequency to be approximately the same. Noise filter technology is adopted to further improve the phase noise. The simulated results show the VCO output covers frequency band from 3.5GHz to 6GHz. And the phase noise is −124.6dBc/Hz at 1MHz offset from a 3.5GHz carrier and −116dBc/Hz at 1MHz offset from a 6GHz carrier. The VCO is fabricated in 0. 13µm CMOS process while consuming 7.8mA from a 1.2V supply. The total area of layout is 0.75×0.68 mm2.
Bridging Psychometrics and Survey Methodology: Can Mixed Rasch Models Identify Socially Desirable Reporting Behavior?

ZEINA N. MNEIMNEH is with the Survey Research Operations, Institute for Social Research, University of Michigan. STEVEN G. HEERINGA is with the Survey Methodology Program, Institute for Social Research, University of Michigan. ROGER TOURANGEAU is with Westat. MICHAEL R. ELLIOTT is with the Survey Methodology Program, Institute for Social Research, University of Michigan. The Lebanese National Mental Health Survey (LEBANON) is carried out in conjunction with the World Health Organization World Mental Health (WMH) Survey Initiative, which is supported by the National Institute of Mental Health (NIMH; R01 MH070884), the John D. and Catherine T. MacArthur Foundation, the Pfizer Foundation, the U.S. Public Health Service (R13-MH066849, R01-MH069864, and R01 DA016558), the Fogarty International Center (FIRCA R03-TW006481), the Pan American Health Organization, Eli Lilly and Company, Ortho-McNeil Pharmaceutical, GlaxoSmithKline, and Bristol-Myers Squibb. We thank the staff of the WMH Data Collection and Data Analysis Coordination Centres for assistance with instrumentation, fieldwork, and consultation on data analysis. None of the funders had any role in the design, analysis, interpretation of results, or preparation of this article. A complete list of all within-country and cross-national WMH publications can be found at http://www.hcp. med.harvard. edu/wmh/. The LEBANON is supported by the Lebanese Ministry of Public Health, the WHO (Lebanon), National Institute of Health/Fogarty International Center (R03 TW006481-01), Sheikh Hamdan Bin Rashid Al Maktoum Award for Medical Sciences, anonymous private donations to IDRAAC, Lebanon, and unrestricted grants from AstraZeneca, Eli Lilly, GlaxoSmithKline, Hikma Pharm, Pfizer, Roche, Sanofi-Aventis, Servier, and Novartis. We thank Mick Couper for his review and discussion of this manuscript; Elie Karam (the principal investigator) for giving us access to the data and for insightful discussions on the topic; Elie Karam, Aimee Nasser Karam, and John Fayyad for their great contribution to the design of the survey and fieldwork support; Hagop Akiskal for insights into the structure of the temperament construct and the development of the scale; Caroline Cordahi Tabet and Lilian Ghandour for their work in interviewer training and adaptation of the CIDI 3.0; Yasmine Chatila for her work in supervising the fieldwork and data cleaning; and Mariana Salamoun for management of the temperament data. Joseph Sedransk served as the editor on this article. *Address correspondence to Michael R. Elliott, Survey Methodology Program, Institute for Social Research, University of Michigan, 426 Thompson St., Ann Arbor, MI 498109; E-mail: mrelliot@umich.edu.
for use

Background. In Japan, a study comparing the effectiveness and safety of irinotecan plus S-1 (IRIS) with those of a combination of 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI) as second-line treatment in patients with advanced or recurrent colorectal cancer demonstrated that IRIS was non-inferior to FOLFIRI. We previously reported that IRIS is also effective as first-line treatment. Patients and Methods. Eligibility criteria included inoperable recurrent colorectal cancer with a confirmed diagnosis of adenocarcinoma, age ≥20 years, and no history of prior chemotherapy. S-1 (40–60 mg twice daily) was given orally on days 1 to 14, and irinotecan (100 mg/m 2 ) and bevacizumab (5 mg/kg) were given intravenously on days 1 and 15 of a 28-day cycle. The primary endpoint was safety. The secondary endpoints included overall response (OR), progression-free survival (PFS), and overall survival (OS). Results. A total of 52 eligible patients were enrolled from October 2007 through March 2009. In safety analysis, the incidences of grade 3 or 4 adverse reactions were as follows: neutropenia, 27%; hypertension, 21%; and diarrhea, 17%. The overall response rate was 57.7%. Median progression-free survival was 16.7 months. Conclusion. IRIS plus bevacizumab is a well-tolerated, highly effective
Purification and Some Properties of Carbon Monoxide Dehydrogenase from Acinetobacter sp. Strain JC1 DSM 3803

A brown carbon monoxide dehydrogenase from CO-autotrophically grown cells of Acinetobacter sp. strain JC1, which is unstable outside the cells, was purified 80-fold in seven steps to better than 95% homogeneity, with a yield of 44% in the presence of the stabilizing agents iodoacetamide (1 mM) and ammonium sulfate (100 mM). The final specific activity was 474 iimol of acceptor reduced per min per mg of protein as determined by an assay based on the CO-dependent reduction of thionin. Methyl viologen, NAD(P), flavin mononucleotide, flavin adenine dinucleotide, and ferricyanide were not reduced by the enzyme, but methylene blue, thionin, and dichlorophenolindophenol were reduced. The molecular weight of the native enzyme was determined to be 380,000. Sodium dodecyl sulfate-gel electrophoresis revealed at least three nonidentical subunits of molecular weights 16,000 (a), 34,000 (if), and 85,000 (-y). The purified enzyme contained particulate hydrogenase-like activity. Selenium did not stimulate carbon monoxide dehydrogenase activity. The isoelectric point of the native enzyme was found to be 5.8; the Km of CO was 150 LM. The enzyme was rapidly inactivated by methanol. One mole of native enzyme was found to contain 2 mol of each of fiavin adenine dinucleotide and molybdenum and 8 mol each of nonheme iron and labile sulfide, which indicated that the enzyme was a molybdenum-containing iron-sulfur flavoprotein. The ratio of densities of each subunit after electrophoresis (a:p:ry = 1:2:6) and the number of each cofactor in the native enzyme suggest a a2iB2y2 structure of the enzyme. The carbon monoxide dehydrogenase of Acinetobacter sp. strain JC1 was found to have no immunological relationship with the enzymes-of Pseudomonas carboxydohydrogena and Pseudomonas carboxydovorans.
Mixed-Income Development The Theoretical Basis for Addressing Poverty Through

can be found at: Urban Affairs Review Additional services and information for http://uar.sagepub. com/cgi/alerts Email Alerts: http://uar.sagepub. com/subscriptions Subscriptions: http://www.sagepub. com/journalsReprints.nav Reprints: http://www.sagepub. com/journalsPermissions.nav Permissions: http://uar.sagepub. com/cgi/content/refs/42/3/369 SAGE Journals Online and HighWire Press platforms): (this article cites 49 articles hosted on the Citations
Performance analysis of WIMAX-WLAN overlay networks using modified dynamic speed sensitive call admission control

The efficient call admission control (CAC) plays an important role in effective utilisation of integrated heterogeneous networks such as IEEE 802.11/wireless local area networks (WLANs) and IEEE 802.16/wireless microwave access (WiMAX). In this paper, modified dynamic speed sensitive CAC (MDSSCAC) is proposed and analysed for loose, tight and hybrid ring-based WiMAX-WLAN overlay networks. MDSSCAC effectively utilises available resources by admitting calls to proper network and enhances Quality of Service by dynamically varying bandwidth reservation for handoff calls based on traffic prediction. MDSSCAC assigns preference for the calls to admit either in WiMAX or in WLAN network based on velocity, location and service type of call. MDSSCAC avoids unnecessary handoff initiated by high-velocity users and effectively balances load between WiMAX and WLAN networks. MDSSCAC yields better performance compared with the existing speed sensitive CAC (SSCAC) and dynamic SSCAC (DSSCAC). The hybrid coupling provides better performance compared with other coupling.
The Comparative Evaluation of Dependency Parsers in Parsing Estonian Master

Natural Language Processing (NLP) technology has been constantly developing and has seen a vast improvement in the last couple of decades. One key task in NLP is dependency parsing that oftentimes is a pre-requisite for many other tasks such as machine translation, Named Entity Recognition (NER) and so on. The idea of dependency parsing is to perform a syntactic analysis of a sentence and extract the grammatical relations among the words in that sentence. Most research on dependency parsing has been focusing on English text parsing. In this thesis, an effort has been made to evaluate and compare the performance of some of the state-of-the-art dependency parsers in parsing Estonian. The dependency parsers chosen for evaluation are: MaltParser, spaCy, Stanford neural network dependency parser (nndep), SyntaxNet and UDPipe. The comparison is done using mainly Labelled Attachment Score (LAS), Unlabelled Attachment Score (UAS) and Label Accuracy (LA). New models for Estonian were trained for the spaCy, Stanford nndep and UDPipe parsers while pre-trained models for the MaltParser and SyntaxNet were used in the experiments.