Miracle-dz/UniFAR-FTUs huggingface dataset:
A measurement method for characterising micro lead on ground shaft surfaces

The detection and characterisation of undesired lead structures on shaft surfaces is a concern in production and quality control of rotary shaft lip-type sealing systems. The potential lead structures are generally divided into macro and micro lead based on their characteristics and formation. Macro lead measurement methods exist and are widely applied. This work describes a method to characterise micro lead on ground shaft surfaces. Micro lead is known as the deviation of main orientation of the ground micro texture from circumferential direction. Assessing the orientation of microscopic structures with arc minute accuracy with regard to circumferential direction requires exact knowledge of both the shaft’s orientation and the direction of surface texture. The shaft’s circumferential direction is found by calibration. Measuring systems and calibration procedures capable of calibrating shaft axis orientation with high accuracy and low uncertainty are described. The measuring systems employ areal-topographic measuring instruments suited for evaluating texture orientation. A dedicated evaluation scheme for texture orientation is based on the Radon transform of these topographies and parametrised for the application. Combining the calibration of circumferential direction with the evaluation of texture orientation the method enables the measurement of micro lead on ground shaft surfaces.
Monitoring of Near-Real-Time SCIAMACHY, MIPAS, and GOMOS Data at ECMWF

At ECMWF near-real-time (NRT) Level 2 data products from SCIAMACHY, MIPAS and GOMOS, the so called Meteo products, are being monitored with the help of the ECMWF assimilation system. These Meteo data include temperature, ozone and water vapour profiles from MIPAS (MIP NLE 2P) and GOMOS (GOM RR 2P), as well as total column ozone data from SCIAMACHY (SCI RV 2P). Currently, the ENVISAT data are obtained in PDS format from the ftp-server ftpops.pdk. envisat.esa. int and are converted into BUFR format at ECMWF. When ENVISAT become reliably available in BUFR format, those BUFR data will be used directly.
THEMED SECTION: VECTOR DESIGN AND DRUG DELIVERY REVIEW Physical methods of nucleic acid transfer: general concepts and applications

Physical methods of gene (and/or drug) transfer need to combine two effects to deliver the therapeutic material into cells. The physical methods must induce reversible alterations in the plasma membrane to allow the direct passage of the molecules of interest into the cell cytosol. They must also bring the nucleic acids in contact with the permeabilized plasma membrane or facilitate access to the inside of the cell. These two effects can be achieved in one or more steps, depending upon the methods employed. In this review, we describe and compare several physical methods: biolistics, jet injection, hydrodynamic injection, ultrasound, magnetic field and electric pulse mediated gene transfer. We describe the physical mechanisms underlying these approaches and discuss the advantages and limitations of each approach as well as its potential application in research or in preclinical and clinical trials. We also provide conclusions, comparisons, and projections for future developments. While some of these methods are already in use in man, some are still under development or are used only within clinical trials for gene transfer. The possibilities offered by these methods are, however, not restricted to the transfer of genes and the complementary uses of these technologies are also discussed. As these methods of gene transfer may bypass some of the side effects linked to viral or biochemical approaches, they may find their place in specific clinical applications in the future. British Journal of Pharmacology (2009) 157, 207–219; doi:10.1111/j.1476-5381.2009. 00032.x; published online 21 January 2009
Hub Gene Screening and Prognostic Modeling of Lung Cancer: An Integrated Bioinformatics Study

Background One of the most frequent malignancies is lung carcinoma which poses heavy burden on the global health. The link among differentially expressed genes (DEGs) and lung cancer patients' clinical outcomes was still missing. In this study, we integrated transcriptome data with clinical data to investigate the relationship between them in lung carcinoma patients. Methods To begin, DEGs were identified using the Gene Expression Omnibus (GEO) gene expression pattern (GSE180347). Then, these DEGs are being searched in the TCGA database using the DEGs collected in the preceding phase. The Kaplan-Meier plotter was then used to assess the predictive value of these DEGs in patients with lung cancer. Results Our study revealed a total of 45 DEGs, 15 of which were up-regulated and 30 of which were down-regulated. These DEGs were mostly enriched in cytokine receptor binding and cytokine activity, according to GO enrichment analysis. These DEGs were mostly enriched in cytokine-cytokine receptor interaction, according to KEGG enrichment analysis. Based on the PPI network, which comprises of 12 DEGs, a major module was discovered. They are mostly interested in cytotoxicity mediated by natural killer cells. Among all 45 DEGs, the mutations of NCAM1 account for the most cases in TCGA database with a percentage above 15%. Among the 12 DEGs in the significant module, higher expression of FAS, GPR29, HAVCR2, and NCAM1 exhibits longer survival time with hazard ratio and 95% confident interval of 0.79 (0.69-0.89), 0.80 (0.70-0.90), 0.71 (0.60-0.84), and 0.73 (0.62-0.86), respectively. However, higher expression of FCGR3A and IFNG exhibits shorter survival time with hazard ratio and 95% confident interval of 1.50 (1.32-1.71) and 1.15 (1.02-1.31), respectively. Conclusion Our results demonstrate significant correlation between some DEGs and the survival outcome in lung adenocarcinomas patients, providing a comprehensive bioinformatics study in anticipation of future molecular mechanisms and biomarker studies.
Alteration in Expression of miR-32 and FBXW7 Tumor Suppressor in Plasma Samples of Patients with T-cell Acute Lymphoblastic Leukemia

Background: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive and malignant neoplasm that arises from the hematopoietic T-cell precursors. Inactivation of FBXW7 gene is frequently observed in T-cell acute lymphoblastic leukemia, suggesting a signi ﬁ cant tumor-suppressive role for FBXW7 in the pathobiology of this leukemia. Considering the role of microRNAs in cell proliferation and regulation of apoptosis, the aim of this study was to identify novel oncogenic microRNAs that suppress FBXW7 in patients with T-ALL. Patients and Methods: The expression levels of two bioinformatically predicted microRNAs – miR-32 and miR-107 were compared in patients with T-ALL and a control group. A total of 80 plasma samples were subjected to RNA extraction, and the microRNA expression pro ﬁ les were assessed by the RT-qPCR. The expression level of miR-103 was used as the endogenous reference for normalization of quantitative data. Results: The plasma levels of miR-32 and miR-107 in patients with T-ALL were signi ﬁ cantly higher (5.65, P < 0.001) and lower (0.432, P = 0.002), respectively. On the other hand, the expression levels of FBXW7 gene were signi ﬁ cantly downregulated by – 76.9 fold in T-ALL patients (P < 0.001). The results of the ROC curve analysis indicated that over-expression of miR-32 might be used to distinguish T-ALL patients with reasonable sensitivity and speci ﬁ city. Conclusion: miR-32 is considered as a novel oncomir that targets FBXW7 and might have a role in the etiology or progression of T-ALL. Furthermore, miR-32 can potentially serve as a non-invasive biomarker for detection of T-ALL.
Control Charts and Feedback Adjustments for a Jump Disturbance Model

We compare the performance of repeated process adjustments to postponed (bounded) adjustments for a model other than the widely used, normal-theory integrated moving average model. We generalize to an interesting, yet practical, alternative jump disturbance model. This model allows the process mean to remain constant for a random time period before a disturbance changes it (and includes a parameter that specifies the rate of mean changes in the process). Because the postponed adjustment can be based on a control chart, these strategies are included. Known analytical results are summarized and simulation is used to extend the performance analysis of different control strategies. We argue that for many process-operating conditions adjustments can be postponed, but that the magnitude of the adjustment (the diligent reaction) is a critical component for success.
Plant Phenolics: Extraction, Analysis and Their Antioxidant and Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer Properties Anticancer Properties

: Phenolics are broadly distributed in the plant kingdom and are the most abundant secondary metabolites of plants. Plant polyphenols have drawn increasing attention due to their potent antioxidant properties and their marked effects in the prevention of various oxidative stress associated diseases such as cancer. In the last few years, the identification and development of phenolic compounds or extracts from different plants has become a major area of health- and medical-related research. This review provides an updated and comprehensive overview on phenolic extraction, purification, analysis and quantification as well as their antioxidant properties. Furthermore, the anticancer effects of phenolics in-vitro and in - vivo animal models are viewed, including recent human intervention studies. Finally, possible mechanisms of action involving antioxidant and pro-oxidant activity as well as interference with cellular functions are discussed. formamidopyrimidine-DNA glycosylase enzyme), glutathione, malondialdehyde, protein carbonyls, Trolox equivalent antioxidant capacity, triglycerides, and DNA binding capacity of the transcription factor nuclear factor-kappa B (NF- κ B). Results show a significant decrease of DNA oxidation damage (P < 0.0001), protein and lipid peroxidation (P < 0.0001 and P < 0.001, respectively), and NF- κ B binding activity (P < 0.01), and an increase of glutathione level and status (both P < 0.0001) during juice uptake. The authors attributed this reduction in oxidative (cell) damage in hemodialysis patients to the especially high anthocyanin/polyphenol content of the juice. The authors concluded that consumption of antioxidant berry juices appears to be a promising preventive measure to reduce chronic diseases such as cancer and cardiovascular disease in population subgroups exposed to enhanced oxidative stress like hemodialysis
Probiotic Supplementation and Respiratory Infection and Immune Function in Athletes: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Objective: To evaluate the effectiveness of probiotic sup- plementation on upper respiratory tract infection (URTI) and inflammatory markers in elite athletes. Data Sources: We searched the PubMed, EBSCOhost, Scopus, and Web of Science databases using the following terms: probiotic OR probiotics AND exercise OR sport OR athletes AND URTI OR respiratory infection OR URTIs OR inflammation OR inflammatory OR cytokines . Study Selection: We screened the titles and abstracts of 2498 articles using our inclusion criteria. A total of 14 articles were selected for further analysis. Data Extraction: For each study, 2 independent reviewers extracted the study design, participant characteristics, inclusion and exclusion criteria, intervention characteristics, outcome measures, and main results. Data Synthesis: We did not observe an effect of probiotic supplementation on the number of days of illness or the mean number or duration of URTI episodes but did note an effect of probiotic supplementation on the total symptom severity score ( (cid:2) 0.65; 95% CI ¼ (cid:2) 1.05, (cid:2) 0.25; P ¼ . 02). Lower levels of interleukin 6 ( (cid:2) 2.52 pg/mL; 95% CI ¼(cid:2) 4.39, (cid:2) 0.66 pg/mL; P ¼ . 002) and tumor necrosis factor a ( (cid:2) 2.31 pg/mL; 95% CI ¼(cid:2) 4.12, (cid:2) 0.51 pg/mL; P ¼ . 01) were also reported after supplementation. Conclusions: This meta-analysis provides evidence that probiotic supplementation, especially among professional athletes, is an effective way to decrease the total URTI symptom severity score. In addition, probiotic supplementation may decrease interleukin 6 and tumor necrosis factor a levels. More studies involving larger groups are needed to better assess this effect. The optimal timing, duration, composition, and dose of such supplementation need to be determined.
Transcurssive Logic as Method

The purpose of this paper is to present the Transcurssive Logic as an auxiliary or complementary method of investigation. This approach differs from the general scientific method in which the research process begins or is sustained in the perspective from which the subject observes reality. This is undoubtedly the only way to highlight what has been so often proclaimed by objective science and rarely accepted, such as intuition and imagination (creation) that leads to finding an answer to small or large enigmas of our world. On the other hand, it will be evident that there is no other way to create new knowledge on a given issue. We present the different levels of approach to reality that must be ‘passed’ if we want to fully characterize this fabulous enigma that represents to investigate the frame of reference where our life unfolds.
Experimental and numerical investigation of residual stresses in laser shock peened AA2198

Laser shock peening (LSP) is a surface treatment which improves the fatigue performance of metallic structures by introducing compressive residual stresses. The aim of this paper is the investigation of LSP of the aluminium alloy AA2198. This investigation includes the variation of the laser power density (2.78 – 25GW/cm 2 ) and the square laser focus (1mm×1mm and 3mm×3mm). Additionally, two di ﬀ erent temper stages (T3 and T8) and thicknesses (3.2mm and 4.8mm) of AA2198 are considered. The study of the LSP process is split into two parts; at ﬁ rst, LSP experiments are performed to clarify the in ﬂ uence of the temper stage, the focus size, the laser power density and the thickness of the specimen on the residual stress ﬁ eld. Secondly, a process model based on the ﬁ nite element method is employed which requires in particular the adjustment of a suitable laser induced pressure pulse. Due to the di ﬀ erent yield strength and strain hardening behaviour of the di ﬀ erent temper conditions, AA2198-T8 shows a lower penetration depth of compressive residual stresses compared to AA2198-T3. A smaller focus size leads to higher compressive residual stresses near the surface but a lower penetration depth. To investigate possible shock wave re ﬂ ections, di ﬀ erent base layers in the LSP process are investigated considering a free, a clamped and a glued back-side of the specimen. No di ﬀ erences in terms of resulting residual stresses were observed. The experimental study provides some preliminary assumptions which are used to simplify the simulation set-up. Residual stresses are measured by the incremental hole drilling method using electronic speckle pattern interferometry (ESPI) as well as synchrotron X-ray di ﬀ raction. The calculated residual stresses in the simulation are averaged layer-wise over a sample area for comparison with the measured residual stresses. The model is used to simulate the LSP process for the considered temper stages and focus sizes to predict the resulting residual stresses. Simulated and measured residual stress pro ﬁ les show for the di ﬀ erent cases very good agreement.
Performance Entitlement by Using Novel High Strength Electrical Steels and Copper Alloys for High-Speed Laminated Rotor Induction Machines

: The laminated rotor Induction Machine (IM), with its simple construction and manufacturing, robustness, ease of control and comparatively lower cost remains by far the most utilized electromechanical energy converter. At very high speeds, traditionally its use is considered to be limited to the previously established operational limits of 2.5 × 10 5 rpm √ kW, beyond which the surface Permanent Magnet (PM) Machine and the solid rotor Induction Machine become the machines available for consideration. The aforesaid limits are derived from the use of classic materials. This paper reviews the recent developments in electrical steels and copper alloys and translates these into the resulting performance entitlement and operational limits through a case study involving a marine application, for which an existing rare-earth PM machine is in use. It is concluded that with novel materials, laminated rotor induction machines can be operated up to 6 × 10 5 rpm √ kW, thus opening the use of the rare-earth free Induction Machine for a wider application range previously limited to PM machines.
THE CONTINGENCIES OF SETTING UP AN EFFECTIVE BUSINESS INTELLIGENCE SYSTEM: THE CASE OF TUNISIAN INDUSTRIAL COMPANIES

The paper offers a conceptual model of the effectiveness of the Business Intelligence (BI) system and organizational performance from a view based on organizational alignment. Considering that organizational alignment mediates the basic relationship between the effectiveness of the BI system and performance. The theoretical framework maintains that the effectiveness of the BI system has a positive impact on organizational performance. The empirical evidence adopts the partial least squares method by exploring the Tunisian context and carrying out a survey of 126 industrial companies in Tunisia that have set up a BI system. Our findings state that the effectiveness of the BI system has a positive impact on organizational alignment, and the latter has a positive impact on business performance. The theoretical and managerial implications are put forward highlighting the human, technological and relational aspects alongside the subject, of setting up the BI system.
Quantum chaos and order based on classically moving reference frames

We develop a mathematically consistent approach for treating the quantum systems based on moving classical reference frames. The classical and quantum exact solutions show excellently classical-quantum correspondence, in which the quantum chaotic coherent states correspond to the classically chaotic motions. Applying the approach to the periodically driven linear and nonlinear oscillators, the regular and chaotic quantum states and quantum levels, and the quantum chaotic regions are evidenced. The results indicate that chaos may cause the collapse of matter wave packets and suppress the quantum effect of energy.
Weight gain among US adults during the COVID‐19 pandemic through May 2021

There have been conflicting reports concerning weight gain among adults during the COVID‐19 epidemic. Although early studies reported large weight increases, several of these analyses were based on convenience samples or self‐reported information. The objective of the current study is to examine the pandemic‐related weight increase associated with the pandemic through May 2021.
Knockout of mlaA increases Escherichia coli virulence in a silkworm infection model

The mlaA gene encodes a lipoprotein to maintain an outer membrane lipid asymmetry in gram-negative bacteria. Although the role of mlaA in bacterial virulence has been studied in several bacterial species, there are no reports of its role in E. coli virulence. In this study, we found that knockout of mlaA in E. coli increased its virulence against silkworms. The mlaA-knockout mutant was sensitive to several antibiotics and detergents, but resistant to vancomycin and chlorhexidine. The mlaA-knockout mutant grew faster than the parent strain in the presence of silkworm hemolymph. The mlaA-knockout mutant also produced a larger amount of outer membrane vesicles than the parent strain. These findings suggest that mlaA knockout causes E. coli resistance to specific antimicrobial substances and increases outer membrane vesicle production, thereby enhancing E. coli virulence properties in the silkworm infection model.
Increasing Warehouse Productivity With an Ergonomic Handheld Scanner

Rugged handheld scanners, known in the industry as rugged mobile computers, are used for critical warehouse operations, such as receiving, order picking, and put-away. The form of rugged scanners has not fundamentally changed since it was introduced to replace pen and clipboard. Warehouses have extracted the maximum available efficiency increases available through today’s handheld rugged scanners, but new operational challenges require new ways to further increase productivity and accuracy. The “line of sight” rugged handheld scanner concept described in this article is designed to enhance the user’s efficiency by eliminating non-value-added wrist motions.
Online Guided Self-help Cognitive Behavioral Therapy With Exposure to Anxiety and Problem Solving in Type 1 Diabetes Mellitus: Case Study

Background Type 1 diabetes mellitus (T1DM) is dependent on self-care to avoid short- and long-term complications. There are several problem areas in diabetes that could be addressed by psychological interventions, such as suboptimal problem-solving strategies and fear of hypoglycemia. There is empirical support for a few psychological interventions, most often cognitive behavioral therapy, with various treatment aims. However, these interventions are largely unavailable in regular diabetes health care. Online guided self-help cognitive behavioral therapy could help achieve greater outreach. Objective We tested a manualized treatment in the early stage for further development, with the long-term aim to increase access to care. The purpose of this report was to show the potential of this newly developed online intervention by describing 2 illustrative cases. Methods An online guided self-help cognitive behavioral therapy protocol featuring problem solving and exposure was developed. The treatment was administered from a secure online platform and lasted for 8 weeks. Case 1 was a male participant. He had a number of diabetes-related complications and was worried about his future. He reported that he had a general idea that he needed to change his lifestyle but found it difficult to get started. Case 2 was a female participant. She had fear of hypoglycemia and unhelpful avoidance behaviors. She kept her blood glucose levels unhealthily high in order to prevent hypoglycemic episodes. Furthermore, she avoided contact with diabetes health care. Results The 2 participants showed clinically significant improvements in their most relevant problem areas. In case 1, the participant’s blood glucose levels reduced, and he was able to establish healthy routines, such as increase physical exercise and decrease overeating. In case 2, the participant’s fear of hypoglycemia greatly decreased, and she was able to confront many of her avoided situations and increase necessary visits to her diabetes clinic. Treatment satisfaction was high, and no adverse events were reported. Conclusions It is possible to deliver a cognitive behavioral therapy intervention aimed at problem areas in diabetes online. Problem solving appears to help with problems in everyday routines and lifestyle choices. Exposure to aversive stimuli appears to be a plausible intervention specifically aimed at the fear of hypoglycemia. Larger and controlled studies are needed.