Miracle-dz/UniFAR-FTUs huggingface dataset:
University of Groningen Gamification for Word Sense Labeling

Obtaining gold standard data for word sense disambiguation is important but costly. We show how it can be done using a “Game with a Purpose” (GWAP) called Wordrobe. This game consists of a large set of multiple-choice questions on word senses generated from the Groningen Meaning Bank. The players need to answer these questions, scoring points depending on the agreement with fellow players. The working assumption is that the right sense for a word can be determined by the answers given by the players. To evaluate our method, we gold-standard tagged a portion of the data that was also used in the GWAP. A comparison yielded promising results, ranging from a precision of 0.88 and recall of 0.83 for relative majority agreement, to a precision of 0.98 and recall of 0.35 for questions that were answered unanimously.
Outpatient Diabetic Care in a Public Central Hospital: Patient Characteristics, Therapeutic Regimens and Results

Background: Report of patient characteristics, treatment and results of diabetic patients assisted at a public tertiary hospital. Patients and Methods: Standardized clinical and analytical data regarding patients assisted during 2 years. Results: Nine hundred and seventy-one visits and 271 patients were studied. Patients with type 1 (DM1) (15%), type 2 treated with insulin (DM2-IT) (23%) and type 2 treated with oral agents (DM2-NIT) (56%) were included. On referral, long-standing disease (11 ± 9 years) was present with poor metabolic control (glycated hemoglobin, HbA1c 8.4 ± 2.0%). Microvascular disease (33-40%), high blood pressure (HBP) (56%) and dyslipidemia (61%) were common. Intensive treatment was used in less than half of the patients. Most of DM2 patients were under medication for HBP and were using anti-platelet agents (76%) but less than half (46%) were using lipid-lowering drugs. Despite frequent medical visits, metabolic control remained poor, HbA1c 8.0 ± 1.9%. In almost half of DM2 patients, systolic blood pressure (45%), serum cholesterol (36%), serum triglycerides (42%) and HDLc (37%) remain higher or lower than recommended. Conclusions: Two fundamental vectors seem to underlie the clinical evolution: aging and beta-cell function. DM2-IT represents a group of specially difficult patients. Intensive medical assistance of diabetic patients is still far from routine even in tertiary hospitals. J Endocrinol Metab. 2014;4(1-2):13-24 doi: http://dx.doi. org/ 10.14740 / jem205w
Microscopic Investigations on Woody Biomass as Treated with Ionic Liquids

Additional information available the chapter Abstract Woody biomass is one of the most promising renewable alternatives to fossil resources. However, some physical and chemical treatment is required to convert their chemical components into biofuels and valuable chemicals because of their low degradative properties. Recently, there has been considerable interest in ionic liquid treatment for biorefinery, and many fundamental studies on the reactivity of wood with ionic liquids have been performed from a chemical and morphological point of view. This chapter highlights the findings regarding morphological and topochemical features of wood cell walls in the degradation process as a result of ionic liquid treatment. Bright-field microscopy and scanning electron microscopy have revealed the swelling behavior of cell walls and the detailed ultrastructural features of wood tissues treated with ionic liquid. Polarized light microscopy and confocal Raman microscopy have clarified the changes in cellulose crystallinity and distribution of chemical compositions such as polysacchar‐ ides and lignin during ionic liquid treatment at the cellular level. [EtPy][Br]. The characteristic Raman bands of were observed at 370, 1331, 1459, 1657, 2848, and 2943 cm −1 , whereas those of the polysaccharides (cellulose and hemicellulose) were observed at 380, 436, 520, 1093, 1118, 1152,
Remodeling of the C. elegans Non-coding RNA Transcriptome by Heat Shock

Elevated temperatures activate a Heat Shock Response (HSR) to protect cells from the pathological effects of protein mis-folding, cellular mis-organization, organelle dysfunction and altered membrane fluidity. This response includes activation of the conserved transcription factor Heat Shock Factor 1 (HSF-1), which binds Heat Shock Elements (HSEs) in the promoters of genes induced by heat shock (HS). The up-regulation of protein-coding genes (PCGs), such as Heat Shock Proteins (HSPs) and cytoskeletal regulators, is critical for cellular survival during elevated temperatures. While the transcriptional response of PCGs to heat shock has been comprehensively analyzed in a variety of organisms, the effect of this stress on the expression of non-coding RNAs (ncRNAs) has not been systematically examined. Here we show that in Caenorhabditis elegans HS induces up- and down-regulation of specific ncRNAs from multiple classes, including miRNA, piRNA, lincRNA, pseudogene, and repeat elements. Moreover, some ncRNA genes appear to be direct targets of the HSR, as they contain HSF-1 bound HSEs in their promoters and their expression is regulated by this factor during HS. These results demonstrate that multiple ncRNA genes respond to HS, some as direct HSF-1 targets, providing new candidates that may contribute to organismal survival during this stress.
Can a Botanic Garden Cycad Collection Capture the Genetic Diversity in a Wild Population?

Premise of research. Conservation of plant species often requires ex situ (off-site) cultivation of living collections. Cycads constitute the most imperiled major group of plants, and ex situ collections are an important part of conservation planning for this group, given seed recalcitrance, difficulties with tissue culture, and ongoing in situ threats. Very little is known about the genetics of ex situ conservation collections of cycads. Thus, this study seeks to illuminate how well an ex situ collection of a cycad can capture the diversity in a wild population. Methodology. A model species, Zamia decumbens, was chosen on the basis of geographic isolation and detailed census knowledge, which allowed near-total sampling of in situ plants. Overall, 375 in situ plants were compared to 205 ex situ plants via 10 microsatellite markers. Pivotal results. Genetic-distance analysis shows high fidelity of the ex situ collections to their in situ source populations as well as clustering of ex situ progeny by accession and strong identity with their respective mother plants. Structured resampling of allele capture from the in situ populations by the ex situ collections shows that allele capture increases as number of ex situ plants maintained increases, but with a diminishing rate of increase. Conclusions. These data demonstrate that botanic garden collections can better conserve the genetic diversity of in situ cycad populations if four recommendations are followed: (1) use the species biology to inform the collecting strategy; (2) manage each population separately; (3) collect and maintain multiple accessions; and (4) collect over multiple years.
89Zr-oxine labelling and PET imaging shows lung delivery of a cell/gene cancer therapy

Purpose MSCTRAIL is a new stem cell-based therapy for lung cancer, currently in phase I evaluation (ClinicalTrials.gov ref: NCT03298763). Biodistribution of cell therapies is rarely assessed in clinical trials, despite cell delivery to the target site often being critical to presumed mechanism of action. This preclinical study demonstrates that MSCTRAIL biodistribution dynamics can be detected non-invasively using 89Zr-oxine labelling and PET imaging, thus supporting use of this cell tracking technology in phase II evaluation. Methods MSCTRAIL were radiolabelled with a range of 89Zr-oxine doses, and assayed for cell viability, phenotype and therapeutic efficacy post-labelling. Cell biodistribution was imaged in a mouse model of lung cancer using PET imaging and bioluminescence imaging (BLI) to confirm cell viability and location in vivo up to 1 week post-injection. Results MSCTRAIL retained therapeutic efficacy and MSC phenotype at doses up to and above those required for clinical imaging. The effect of 89Zr-oxine labelling on cell proliferation rate was dose and time-dependent. PET imaging showed delivery of MSCTRAIL to the lungs in a mouse model of lung cancer, with PET signal correlating with the presence of viable cells as assessed by bioluminescence imaging, ex vivo autoradiography and matched fluorescence imaging on lung tissue sections. Human dosimetry estimates were produced using simulations and preclinical biodistribution data. Conclusion 89Zr-oxine labelling and PET imaging present an attractive method of evaluating the biodistribution of new cell-therapies, such as MSCTRAIL. This offers to improve understanding of mechanism of action, migration dynamics and interpatient variability of MSCTRAIL and other cell-based therapies.
Considerations on the thermal equilibrium between matter and the cosmic horizon

A common feature in the thermodynamic analysis of homogeneous and isotropic world models is the assumption that the temperature of the fluids inside the cosmic horizon (including dark energy) coincides with the temperature of the latter, whether it be either the event or the apparent horizon. We examine up to what extent this assumption may be justified, given that these temperatures evolve under different time-temperature laws. We argue that while radiation cannot reach thermal equilibrium with the horizon, nonrelativistic matter may, and dark energy might though only approximately.
contamination contributes to apparent microstructural alterations in mild cognitive impairment

a Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, 16 De Crespigny Park, London SE5 8AF, UK b Department of Neurology, University Medical Centre Ljubljana, Zaloska 2, 1000 Ljubljana, Slovenia c Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Park Place, Cardiff CF10 3AT, UK d The Neuroscience and Mental Health Research Institute, Cardiff University, Park Place, Cardiff CF10 3AT, UK
Academic Cooperation: Analysis of Publications on Accounting Teaching and Research in Scientific Events

Scientific knowledge is socially developed, based on the collaboration among the authors involved in the process. Departing from this premise, the aim in this study is to map, through the analysis of social networks, collaborative interactions in studies on Accounting Teaching and Research. Therefore, 215 articles were analyzed about the research theme, published in the proceedings of Enanpad, the USP Controllership and Accountancy Congress and Anpcont. The social network analysis method was used to develop the collaborative partnership structures in the study period, ranging from 1999 to 2009. In addition, we intended to check whether the researchers’ centrality indicators are associated with their production, using Spearman’s non-parametric t-test. Centrality identifies the most important authors in a social network in which, the more central, the more relevant these authors’ contribution. At the end of the study, the most important researchers and higher education institutions for the area came out, in terms of the number of authorships as well as the intermediation these researchers and institutions provide. Among the researchers, Gilberto de Andrade Martins and Edgard Bruno Cornachione Jr. stood out, representing the most productive experts. Both are affiliated with Emerson Muniz Freitas, Vicente Pacheco, Regina Maria Karolkievicz and Edson Paes Sillas REPeC – Revista de Educacao e Pesquisa em Contabilidade, ISSN 1981-8610, Brasilia, v. 6, n. 4, art. 4, p. 374-392, oct./dec. 2012 375 the University of Sao Paulo, the Higher Education Institution (HEI) responsible for the highest number of authorships during the period. In addition, through the analysis of the association between the researchers’ centrality indicators and scientific production volume, a significantly positive association was identified. Thus, it was verified that, the greater the intermediation and co-authorship relations with other experts, the more articles the authors under analysis publish.
Proteomic profiling and biological characterization of extracellular vesicles isolated from Alzheimer\'s disease brain tissues

Abstract Introduction Extracellular vesicles (EVs) isolated from human biospecimens contains AD pathogenic molecules, such as amyloid-β peptide (Aβ) and tau, may play a role in the spread of disease in human brain. There is no comprehensive characterization of the molecules in human tissue-derived EVs. We therefore examined the protein composition of EVs isolated from the human brain tissue from patients with AD and an age- and sex-matched control group (CTRL). Methods EVs were isolated from the cortical grey matter of AD (n=20) and Control (n=18). Tau and Aβ in the EVs were measured by immunoassay. Differentially expressed EV proteins were observed by quantitative proteomics employing machine learning. Results The levels of pS396 tau and Aβ were significantly enriched in AD EVs. Proteomic profiling shows enrichment of neuron-specific molecules in control EVs, and glial cell type-specific molecules in AD EVs. Machine learning approach of training group identified annexin A5 (ANXA5), neurosecretory protein VGF, neuronal membrane glycoprotein M6-a (GPM6A), and alpha-centractin (ACTZ) as most distincive molecules in AD EVs compared to the CTRLs. Each of the proteins were confirmed with 88% accuracy in testing group. Discussion These data posit that in addition to Aβ and tau, the protein levels of ANXA5, VGF, GPM6A, and ACTZ are significantly altered in AD brain-derived EVs.
Sap and the Traditional Healer: A Tribal (Khasi) Understanding of the Human Potential

This paper presents factors contributing to the “making of” nongai dawai, a Khasi healer. The Khasi community’s understanding of what is referred to as a key component of becoming a good healer, sap—loosely translated as talent or potential—is elaborated. Sap is a generic term, not restricted to a specific field but we explore here its importance to Khasi understandings of the recruitment and recognition of those best suited to be healers. The presence of such concepts within indigenous knowledge systems suggests that including the assessment of “aptitude” or “potential” remains important in career guidance even in the present times.
Quality traits of green plums (Prunus cerasifera Ehrh.) at different maturity stages

Fruits of 2 different plum cultivars (Prunus cerasifera Ehrh.) were collected in 2015 from 15-year-old trees in Hatay Province, Turkey. The 2 plum cultivars (Can and Gul) were on their own roots. Fruits were picked 5 times (both Can and Gul) at 12-day intervals (12 April [t1], 24 April [t2], 6 May [t3], 18 May [t4], and 30 May [t5]) during maturation in 2015. Higher levels of health-promoting components with the capacity to prevent several diseases, such as phenolic compounds with antioxidant activity, were found in the Can fruits, whereas the Gul fruits were characterized by lower values. The amounts of individual sugars providing taste and the soluble sugar content of the fruits differed between the 2 cultivars, with glucose and fructose being higher in the Can variety. The results show the importance of green plums in the daily diet as a good source of total phenols and antioxidants, providing health-promoting effects in humans, with good edible properties at the pre-early development stage.
Venture Capitalists Approach To Strategy And Corporate Governance Of Portfolio Companies: The Case Of Tbl Mirror Fund

Venture capital refers to a full range of financial services provided by experienced professionals to new or radically innovative changing firms. The financial services include financing of ventures, providing expertise with business planning, providing industry knowledge, instilling corporate governance and providing guidance to management. The purpose of the study was to examine establish the approach of venture capitalists to the strategy and corporate governance of its portfolio companies. The study sought to determine the influence by the venture capitalist on the strategic direction of its portfolio companies, establish the corporate governance practice which the venture capitalist applies and the impact of these practices on the portfolio companies. The study was on one of the practicing venture capitalists in Kenya, TBL Mirror Fund. Primary data used in the study was collected using interviews which the researcher conducted with the Fund managers of TBL Mirror Fund. The results showed that the studied firm undertakes significant actions towards corporate governance and strategy re-direction of its portfolio companies. The firm assists to strengthen the portfolio companies’ governance system through proper due diligence, the appointment of a competent and independent board of directors, an appropriate management incentive program, establishment of a close relationship with management, and periodic management reports. The key to efficient governance is to give the portfolio firms support to focus on operational and strategic issues in the board meetings. Further studies should be carried out to determine whether the different characteristics of different venture capitalists lead to different approaches towards the strategy and corporate governance of their portfolio companies.
THE EFFECTS OF QUALITY FACTORS OF WEB-BASED INFORMATION SYSTEM ON THE EMPLOYEE CONTEXTUAL PERFORMANCE

Assessing the effectiveness of Web-based Information System (WBIS) is increasingly needed as it has a significant contribution to organizations, particularly on the employee performance. This study is one of the fewest in the field of WBIS assessment in which the effectiveness of WBIS is assessed in terms of contextual performance. It aims at evaluating the impact of quality factors of WBIS: system quality, information quality and service quality on the employee’s contextual performance. The study is conducted in Palestine, Gaza. The data of the pilot study is collected from 51 of WBIS users. Concerning the statistical inferential and analytical tests, correlation and regression analysis are used to analyze the data and obtain the results. The findings indicate that there are strong correlations between study factors. However, it is found that system quality is not significantly related to contextual performance. Also, the findings indicate there are significant relationships between information quality, service quality and contextual performance at significance level less than 0.05. Consequently, the proposed model would contribute to literature gap and empirical studies in the field of IS effectiveness assessment.
Identification of a Prognostic Signature Associated With DNA Repair Genes in Ovarian Cancer

Introduction: Ovarian cancer is a highly malignant cancer with a poor prognosis. At present, there is no accurate strategy for predicting the prognosis of ovarian cancer. A prognosis prediction signature associated with DNA repair genes in ovarian cancer was explored in this study. Methods: Gene expression profiles of ovarian cancer were downloaded from the GEO, UCSC, and TCGA databases. Cluster analysis, univariate analysis, and stepwise regression were used to identify DNA repair genes as potential targets and a prognostic signature for ovarian cancer survival prediction. The top genes were evaluated by immunohistochemical staining of ovarian cancer tissues, and external data were used to assess the signature. Results: A total of 28 DNA repair genes were identified as being significantly associated with overall survival (OS) among patients with ovarian cancer. The results showed that high expression of XPC and RECQL and low expression of DMC1 were associated with poor prognosis in ovarian cancer patients. The prognostic signature combining 14 DNA repair genes was able to separate ovarian cancer samples associated with different OS times and showed robust performance for predicting survival (Training set: p < 0.0001, AUC = 0.759; Testing set: p < 0.0001, AUC = 0.76). Conclusion: Our study identified 28 DNA repair genes related to the prognosis of ovarian cancer. Using some of these potential biomarkers, we constructed a prognostic signature to effectively stratify ovarian cancer patients with different OS rates, which may also serve as a potential therapeutic target in ovarian cancer.
Analyzing combined eye-tracking/EEG experiments with (non)linear deconvolution models

Fixation-related potentials (FRPs), neural responses aligned to saccade offsets, are a promising tool to study the dynamics of attention and cognition under natural viewing conditions. In the past, four methodological problems have complicated the analysis of combined eye-tracking and EEG experiments: (i) the synchronization of data streams, (ii) the removal of ocular artifacts, (iii) the condition-specific temporal overlap between the brain responses evoked by consecutive fixations, (iv) and the fact that numerous low-level stimulus and saccade properties also influence the post-saccadic neural responses. While effective solutions exist for the first two problems, the latter ones are only beginning to be addressed. In the current paper, we present and review a unified framework to deconvolve overlapping potentials and control for linear and nonlinear confounds on the FRPs. An open software implementation is provided for all suggested procedures. We then demonstrate the advantages of this analysis approach for three commonly studied free viewing paradigms: face perception, scene viewing, and natural sentence reading. First, for a traditional ERP face recognition experiment, we show how deconvolution can separate stimulus-ERPs from the overlapping muscle and brain potentials produced by small (micro)saccades on the face. Second, in natural scene viewing, we isolate multiple non-linear influences of saccade parameters on the FRP. Finally, for a reading experiment using the classic boundary paradigm, we show how it is possible to study the neural correlates of parafoveal preview after removing the spurious overlap effects caused by the difference in average fixation time. Our results suggest a principal way of measuring reliable fixation-related potentials during natural vision.
Musumecia gen. nov. in the Tricholomatoid clade (Basidiomycota, Agaricales) related to Pseudoclitocybe

Musumecia, a new genus of Agaricales, is described to accommodate the new species Musumecia bettlachensis. Based on a combined ITS– and LSU–rDNA Bayesian, Maximum Likelihood and Maximum Parsimony analysis, Musumecia clearly clusters within the Tricholomatoid clade, where it is sister to Pseudoclitocybe. Musumecia is distinguished from allied genera by a unique combination of macro- and micromorphological characters, including basidiomes with a clitocyboid/hygrophoroid habit, emerging from a fleshy pseudosclerotial mass (pseudosclerotium), decurrent and thick lamellae, a brown darkening of both lamellae and stipe, whitish-cream spore print, elongated non-siderophilous basidia, smooth, acyanophilous and inamyloid basidiospores, and the absence of both cystidia and clamp-connections.
Thermal effects on nonlinear vibrations of an axially moving beam with an intermediate spring-mass support

The thermo-mechanical nonlinear vibrations and stability of a hinged-hinged axially moving beam, additionally sup- ported by a nonlinear spring-mass support are examined via two numerical techniques. The system is subjected to a transverse harmonic excitation force as well as a thermal loading. Hamilton's principle is employed to derive the equations of motion; it is discretized into a multi-degree-freedom system by means of the Galerkin method. The steady state resonant response of the system for both cases with and without an internal resonance between the first two modes is examined via the pseudo-arclength continuation technique. In the second method, direct time integration is employed to construct bifurcation diagrams of Poincare maps of the system.