Miracle-dz/UniFAR-FTUs huggingface dataset:
Mushroom: A New Resource for Anti-Angiogenic Therapeutics

ABSTRACT Anti-angiogenic therapy is described as a targeted prognosis to cure cancer in advanced stages. But the use of synthetic drug molecules causes various side effects. A failure of synthesized molecules to prevent the advancement of cancer followed by neovascularization has drawn focus towards naturally obtained product application. Mushrooms are appreciated as a valuable source of food and medication since the time immemorial. In recent days, the effects are being analyzed in a molecular aspect. Non-toxicity towards normal cell populations gave advantages to mushroom products on synthetic molecules. Researchers across the world have described the anti-angiogenic role of mushroom extract or purified bio-molecules. The present review gives an update on component biomolecules i.e. triterpenoids, isoflavones, and glycoproteins are applied as small molecule-mediated impedance or activate macromolecule proteins to modulate the immune response. A Lanostane group of triterpenoids from different mushrooms has been explored to find out the inhibitory property on angiogenesis inducing growth factors like VEGF, PDGF, EGF and their receptors. In recent days, a molecular mechanism to control VEGF mediated signaling pathway elaborated by mushroom glycoprotein induced immunomodulation on NF-κB, MMPs, and inflammatory cytokines. Flavonoid fermentation by Ganoderma lucidum has opened a new window of immunomodulation treatment to control tumor angiogenesis.
A Bayesian Nonparametric Topic Model for Microbiome Data Using Subject Attributes

: Microbiome data have been obtained relatively easily in recent years, and currently, various methods for analyzing microbiome data are being proposed. Latent Dirichlet allocation (LDA) models, which are frequently used to extract latent topics from words in documents, have also been proposed to extract information on microbial communities for microbiome data. To extract microbiome topics associated with a subject’s attributes, LDA models that utilize supervisory information, including LDA with Dirichlet multinomial regression (DMR topic model) or supervised topic model (SLDA,) can be applied. Further, a Bayesian nonparametric model is often used to automatically decide the number of latent classes for a latent variable model. An LDA can also be extended to a Bayesian nonparametric model using the hierarchical Dirichlet process. Although a Bayesian nonparametric DMR topic model has been previously proposed, it uses normalized gamma process for generating topic distribution, and it is unknown whether the number of topics can be automatically decided from data. It is expected that the total number of topics (with relatively large proportions) can be restricted to a smaller value using the stick-breaking process for generating topic distribution. Therefore, we propose a Bayesian nonparametric DMR topic model using a stick-breaking process and have compared it to existing models using two sets of real microbiome data. The results showed that the proposed model could extract topics that were more associated with attributes of a subject than existing methods, and it could automatically decide the number of topics from the data.
Guidelines for the Design of Finite Control Set Model Predictive Controllers

Direct model predictive control (MPC) with reference tracking, also referred to as finite control set MPC (FCS-MPC), has gained significant attention in recent years, mainly from the academic community. Thanks to its applicability to a wide range of power electronic systems, it is considered a promising control method for such systems. However, to simplify the design, researchers frequently make choices that—often unknowingly—reduce the system performance. In this article, we discuss and analyze the factors that affect the closed-loop performance of FCS-MPC. Based on these findings, design guidelines are provided that help to maximize the system performance. To highlight the performance benefits, two case studies will be considered: the first one consists of a two-level converter and an induction machine, whereas the second one adds an $LC$ filter between the converter and the machine.
Kerajaan dan Komunitasnya: Sejarah dan Teori Keberadaan Komonitas Bahari di Masa Sriwijaya

Sriwijaya adalah satu dari beberapa kerajaan besar yang pernah berjaya di wilayah Nusantara. Letaknya diyakini berada di pinggiran sungai Musi menguatkan beberapa teori tentang penguasaan Sriwijaya terhadap jalur perdagangan di Nusantara kala itu. Penelitian ini bertujuan untuk menggali kembali berbagai teori dan versi sejarah tentang berkembangnya komunitas bahari di wilayah kerajaan Sriwijaya. Metode yang digunakan adalah metode historis analisis objek kajian berkenaan dengan peristiwa atau objek masa lampau. Analisis komparatif juga dibutuhkan karena berkenaan dengan teori tentang keberadaan masyarakat bahari. Dari hasil penelitian didapatkan bahwa kemungkinan adanya masyarakat bahari pada masa kerajaan Sriwijaya adalah sangat kuat. Hal ini didukung dengan data historis dari beberapa catatan pelawat ke wilayah Sriwijaya saat itu. Salah satu di antaranya adalah Chau Ju-Kua, seorang pegawai resmi Dinasti Song yang menuliskan dalam bukunya Chu-fan-chi tentang masyarakat Sriwijaya yang saat itu tinggal di atas rumah-rumah apung meski ia sendiri hanya mendapatkan informasi tersebut dari para pelancong yang datang ke Sriwijaya dan bertemu dengannya di Guangzhou, salah satu kota terbesar di Cina selatan.
First-in-human study of LY3039478, a Notch signaling inhibitor in advanced or metastatic cancer.

2533 Background: LY3039478 (LY) is an orally bioavailable, potent, and highly selective Notch inhibitor (Notch 1-4). We report on safety, pharmacokinetics (PK), pharmacodynamics (PD), and anti-tumor activity of LY. Methods: Eligible pts (ECOG ≤ 1) had relapsed solid tumors, adequate hematologic, renal, and hepatic functions. Using a predictive pre-clinical PK/PD model and non-clinical toxicology data, a dose range of 2.5-100 mg was selected. LY was given three times a week (TIW) on a 28-day cycle until disease progression. Dose escalation used 3+3 design with probability toxicity band modelling. Safety assessments were based on CTCAE V4.0. Primary objective: to define the recommended phase 2 dose of LY; additional objectives: PK, PD (Aβ in plasma and a panel of 46 genes expressed in skin), and preliminary antitumor activity. Results: 55 pts were treated. The most common related toxicities ( ≥ 10% of pts) included diarrhea (42%); vomiting (40%); nausea (36%); asthenia (33%); decreased appetite (25%); hypop.
Investigating Sustainable Practices in Hotel Industry-from Employees’ Perspective: Evidence from a Mediterranean Island

Although several studies have researched the hotel employees’ environmental behavior, none has addressed the hotel employees’ perception of their respective hotels’ sustainability practices. This study aims to investigate the sustainable practices in four and five star hotels in a Mediterranean island by employing Global Sustainable Tourism Council (GSTC) hotel criteria indicators, indicators of sustainable development for tourism destinations (WTO), and the European Union’s (EU) sustainability framework for the Mediterranean hotels− “Nearly Zero-Energy Hotels” (NEZEH), and global sustainable development goals (SDG) in the context of three dimensions: social, economic and environment. The sampled hotels claim that their operation system is conformed to sustainability principles with the aim of furthering their green agenda. In this study, we aim to investigate the validity and extent of this claim. About 290 (N = 290) employees in the specified hotels were surveyed. The measurement instruments were compiled based on sustainability indicators that encompassed addressing social, economic, and environmental dimensions. The research questions contextualized around four main themes: effective sustainability planning, maximizing social and economic benefits for the local community, enhancing cultural heritage, and reducing negative environmental impacts. For the statistical and data analysis, SEM (structural equation modeling) is used. Study revealed that employees are a legitimate and credible source of information about sustainability practices. It is also revealed that as going green is becoming a means toward branding, hotels are making efforts to implement a genuine sustainability practice. Study also indicated that the majority of employees validated the sustainability practices as genuine.
A Population Based Perspective of Children and Youth with Acquired Brain Injury in Ontario, Canada

Acquired brain injury (ABI) includes traumatic (TBI) and non-traumatic brain injury (nTBI). It is a leading cause of death and disability worldwide and can negatively affect the long-term development of children and youth living with an ABI. The objective of this thesis was to address current gaps in pediatric ABI research by (1) establishing the foundation for efforts to reach an appropriate case definition for pediatric TBI; (2) addressing the paucity of information on the health service use of children and youth with nTBI; and (3) expanding current knowledge on children and youth with a brain tumour by including data on individuals with metastatic and non-malignant brain tumours. Population based healthcare administrative data from Ontario, Canada, were used and children and youth with an ABI were identified using International Classification of Diseases Version 10 codes. Results showed that the number and rate, healthcare use, and intentional and mechanism of injury differed significantly when including/excluding ‘unspecified injury to the head’ diagnostic codes in the case definition for TBI, providing evidence for the importance of accurately interpreting current findings for the TBI population in reference to the case definition. Data also showed that although the rate of nTBI episodes of care was not as high as the rates reported for the TBI population, the health service use among the nTBI population was just as high as the TBI population. This suggests that the pediatric nTBI iii population puts an increased burden and demand on the healthcare system with currently little data to direct resources and planning. Finally, despite higher rates of malignant brain tumour episodes of care, patients with benign and unspecified brain tumours also use acute care and post-acute care services, indicating that current estimates for brain tumour and associated healthcare use are underestimates. This thesis provided a comprehensive update on children and youth with ABI from a population based perspective that has implications for policy and decision-making, health services planning, and resource allocation for ABI.
ОБРАБОТКА ИЗОБРАЖЕНИЙ , РАСПОЗНАВАНИЕ ОБРАЗОВ A novel switching bilateral filtering algorithm for depth map

In this paper, we propose a novel switching bilateral filter for depth map from a RGB-D sensor. The switching method works as follows: the bilateral filter is applied not at all pixels of the depth map, but only in those where noise and holes are possible, that is, at the boundaries and sharp changes. With the help of computer simulation we show that the proposed algorithm can effectively and fast process a depth map. The presented results show an improvement in the accuracy of 3D object reconstruction using the proposed depth filtering. The performance of the proposed algorithm is compared in terms of the accuracy of 3D object reconstruction and speed with that of common successful depth filtering algorithms
Factors Related to Employment Outcomes for Vocational Rehabilitation Consumers with Visual Impairments: A Systematic Review

Introduction: The purpose of this article was to conduct a systematic review of peer-reviewed studies on factors related to employment in consumers who are visually impaired using Rehabilitation Services Administration (RSA-911) Case Service Report data. Methods: We used database, hand, and ancestral search strategies to systematically identify peer-reviewed studies published between 1990 and August 2018 where researchers used RSA-911 data to address the target question. All included articles were coded by two reviewers for study and participant characteristics, quality indicators, and outcomes. Results: Nine articles consisting of 14 analyses were included. Twelve analyses concerned employment outcomes; two concerned earnings. Researchers in most studies used large samples of 3,000 or more consumers and used multivariable analyses, most commonly multilevel logistic regression. Factors that consistently predicted lower employment across studies included presence of a secondary disability and legal blindness; higher education level consistently predicted higher employment, as did earnings and self-support at vocational rehabilitation application. Few analyses included state- or agency-level variables or specific vocational rehabilitation services. Discussion: These results indicate that certain groups of vocational rehabilitation consumers with visual impairments may be at greater risk of unsuccessful closures; researchers should examine specific strategies that may improve outcomes in these groups. These results also highlight the importance of education in securing employment among people with visual impairments. Researchers should examine state- and agency-level variables that may affect outcomes as well as the effects of specific services on outcomes. Additionally, researchers should analyze factors that may affect employment quality as well as employment outcomes. Implications for practitioners: Practitioners who are working with visually impaired people who do not have a postsecondary degree should encourage and assist their clients in obtaining one; practitioners may also wish to provide more targeted support for consumers from potentially high-risk subpopulations.
Clinical governance leads: roles and responsibilities

Clinical governance leads in primary care trusts play a crucial role in embedding the pursuit of excellence within their healthcare organisation. They are often the A½ first point of contact for any issue relating to general practitioner appraisal, poor performance, quality and standards, be they clinical or organisational. However, for many clinical governance leads their job seems daunting, with no clear boundary around their roles and responsibilities, and no clarity about their own personal development such that they can acquire the skills and competencies for their work. Using the NHS Knowledge and Skills Framework and reA½fined by stakeholder consultation this document sets out a framework for primary care trusts’ clinical governance leads. It attempts to deA½ ne the core activities, skills required and support needed to meet these activities. These can be used to compose a template for a job description and person speciA½ cation for a competent clinical governance lead.
Theoretical and Experimental Investigation of Variable Stiffness Finger Seal

Abstract A finger seal is a flexible and dynamic contact seal, and many researches and experiments have proved its application potential in aviation engines, gas turbines, and other equipment. However, the contradiction between hysteresis leakage and wear life in the design and initial installation condition of finger seals seriously affects the integrated performance design effect. A variable stiffness finger seal is investigated in the present study to resolve the aforementioned problems, and the influence of initial installation condition is considered. First, a theoretical model of the finger seal is established to calculate the hysteresis characteristic and contact pressure between finger feet and rotor. The performances of the variable stiffness finger seal and traditional involute curved finger seal are compared to confirm the advantages of the variable stiffness finger seal. The results show that the initial conditions such as rotor structure and support bearing clearance have an important influence on the accuracy of finger sealing performance calculation. In addition, the variable stiffness structure improves the hysteresis characteristic of the finger seal with virtually no loss of wear life under low pressure differential and reduces the hysteresis rate by more than 50%. Under high pressure differential, the variable stiffness structure reduces the average contact pressure by more than 25%. Therefore, the leakage and wear performance of the finger seal are simultaneously improved by the variable stiffness structure. This characteristic does not change with an increase in rotor excitation. This indicates that the variable stiffness finger seal provides good synthetic performance and high dynamic adaptability to random operating conditions.
DCE-MRI for assessment of hypoxia-induced prostate cancer aggressiveness

Prostate cancer is a disease characterized by severely heterogeneous behavior. Some tumors remain indolent, and without risk for the patient for many years, while others can progress to life threatening disease rapidly. This represents a challenge when choosing therapeutic modalities for patients diagnosed with prostate cancer, as the aggressiveness of the therapy should be in concordance with the aggressiveness of the disease. The clinical management of prostate cancer continues to be controversial, without clear consensus on choice of diagnostic tests or treatment modality. In this study the potential of using functional magnetic resonance imaging(MRI) to assess the aggressiveness of prostate cancer has been explored, and parameters obtained from dynamic contrast enhanced(DCE) MRI have been correlated to clinical data obtained from biopsies and post-surgical examinations of the prostate gland. Particularly the prognostic power of hypoxia levels, and the ability of MRI to reflect the levels of hypoxia have been examined. The aims of this study is to combine and correlate data from functional MRI, molecular signatures of hypoxia, and tumor hypoxia, with the goal being prediction of prostate cancer aggressiveness. The endpoints of prostate cancer aggressiveness in this study is the clinical data obtained from assessment of histopathological specimens at the time of surgery. This project included 79 patients diagnosed with intermediate and highrisk prostate cancer(D’Amico risk classification), referred to Oslo University Hospital, Radiumhospitalet, for surgical treatment. In vivo functional MRI examination, DCE imaging of the prostate, were preformed on the patients within a few days prior to surgery. Within 24 hours prior to surgery the patients received a dose of pimonidazole, either intravenously or orally, by pill, to act as a hypoxia marker which was used to assess the hypoxia in the prostatectomy specimens after the surgery. The dynamic images provided have been analyzed using pharmacokinetic
Influence of Mechanical Properties on Modal Analysis of Natural Fiber Reinforced Laminated Composite Trapezoidal Plates

ABSTRACT Present work concentrates on modal parameters of laminated composite plates composed of natural fibers reinforced with unsaturated polyester resin. The selected jute and ramie fibers underwent alkaline treatment to improve mechanical properties. Upon compression molding, the laminated composite plates such as ramie/polyester (R plate), jute/polyester (J plate) and combination of ramie and jute (RJ plate) are fabricated. The physical, mechanical and elastic properties are calculated as per ASTM standards. Using obtained elastic properties, the free undamped vibration analysis of composite plates are computed using finite element software ANSYS 18.1 for trapezoidal plates, with respect to a/b = 1 and 2, c/b = 0.25 to 1 and a/h = 50. The natural frequency and mode shape of the plates are obtained for various boundary conditions such as CFFF, CFCF, CCCC, SFSF and SSSS (C-Clamped, F-Free and S-Simply supported). The dimensionless frequency and mode shapes of R, J and RJ plates are compared with literatures which are in good agreement.
Student’s entrepreneurial orientation and intentions

PurposeThis study is aimed to measure and understand the relationship between individual entrepreneurial orientation (IEO) and entrepreneurial intention (EI) among students of higher learning institutions (HLI’s) in India. This study is focused on understanding IEO dimension of proactiveness, innovativeness and risk-taking attitude and EI across gender, academic background, and regions. Many recent and past studies confirm that there is an apparent gap in the literature to understand this phenomenon among students of higher learning institutions.Design/methodology/approachThe study is based on a sample of 393 students studying in 35 different universities and institutions in the North, South and Western regions of India. The data were analyzed using hierarchical regression and ANOVA.FindingsThe empirical result shows a relationship and a positive impact of individual entrepreneurial orientation dimensions upon entrepreneurial intentions. Controlling for gender, males depict higher perseverance toward individual entrepreneurial orientation and entrepreneurial intentions. The same result was found for management and entrepreneurship students who also depict a higher (mean) t-value than science, engineering students. The findings of this study reveal a significant contribution to the academic literature by highlighting the influencing role of gender, academic background, and region upon entrepreneurial intentions.Practical implicationsThe study reveals that institutional culture, lack of academic rigor, regional difference, economic gaps, gender perception, and overall culture may be considered as bothering forces for entrepreneurship to grow via institutions. These forces, if eliminated, can help build an institutional environment helpful for entrepreneurial progression in the country.Originality/valueThere are limited studies available in the context of individual entrepreneurial orientation and entrepreneurial Intention relationship. This study provides the analysis for Indian regions and uses data collected from different universities and institutions of India.
Formal organizations and interstitial spaces: Catalysts, complexity, and the initiation of cross-field collaboration

Interstitial spaces are informal settings where interactions among actors from different organizational fields are more likely to succeed despite the institutional complexity that they face. Individuals acting as “catalysts” have been identified as being particularly important in the dynamics of these interstitial spaces. However, the focus to date has been on individuals interacting in interstitial spaces that have developed informally, and we know little about how formal organizations might purposefully create and manage interstitial spaces to initiate cross-field interaction. Using data from a study of six organizations involved in technology transfer activities between universities and industry in Italy, we explore how formal organizations use interstitial spaces to encourage cross-field collaboration and identify the set of formal and informal activities employed by catalysts to manage the complexity that arises. In addition, our analysis identifies two activities implemented at the organizational and field level by the formal organizations to support the interstitial spaces. Based on these results, we develop a model of the management of interstitial spaces by formal organizations.