Miracle-dz/UniFAR-FTUs huggingface dataset:
Trimethoxycinnamates and Their Cholinesterase Inhibitory Activity

A series of twelve nature-inspired 3,4,5-trimethoxycinnamates were prepared and characterized. All compounds, including the starting 3,4,5-trimethoxycinnamic acid, were tested for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in vitro; the selectivity index (SI) was also determined. 2-Fluororophenyl (2E)-3-(3,4,5-trimethoxyphenyl)-prop-2-enoate demonstrated the highest SI (1.71) in favor of BChE inhibition. 2-Chlorophenyl (2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate showed the highest AChE-inhibiting (IC50 = 46.18 µM) as well as BChE-inhibiting (IC50 = 32.46 µM) activity with an SI of 1.42. The mechanism of action of the most potent compound was determined by the Lineweaver–Burk plot as a mixed type of inhibition. An in vitro cell viability assay confirmed the insignificant cytotoxicity of the discussed compounds on the two cell lines. Trends between structure, physicochemical properties and activity were discussed.
Design of a Low-Noise, Fast Set-up and Low-Voltage Low-Dropout Regulator Featuring 230mA Load Current Range

Low noise, high PSRR and fast transient low-dropout (LDO) regulators are critical for analog blocks such as ADCs, PLLs and RF SOC, etc. This paper presents design of low power, fast transient, high PSRR and high load-regulation low-dropout (LDO) regulator. The proposed LDO regulator is designed in 180nm. CMOS process and simulated in LTSpice and Cadence platform. The LDO proposed can support input voltage range up to 5V for loading currents up to 230mA. Measurements showed transient time or set-up time of less than 22µs, PSRR of ~66dB at 100kHz and >40dB at 1MHz and 0.8535mV of output voltage variation for a 0-230mA of load variation.
‘Un’-blocking the industry 4.0 value chain with cyber-physical social thinking

ABSTRACT Integration of diverse technologies fuels business-model transformation, evolving new applications. Industry 4.0 utilizes emerging-technologies like IoT, AI to make next-generation manufacturing-processes more efficient and agile. Cyber physical systems (CPS) augmented with social, thinking technologies effectuate cyber physical social thinking systems (CPST). Distributed Ledger Technologies (DLT) like Blockchain are synergistic with architectural-elements of such industry-blueprints. Extant literature explores contextual-roles of distinct technology-components as-well-as their limited-combinations; clearly necessitating consideration of integrated-applications. This contemporary conceptual paper: (i) concisely analyses potential-synergies amongst Blockchain, CPST technologies; (ii) proposes novel integrated architecture; (iii) outlines underlying challenges, opportunities and performance considerations; bearing benefits beyond traditional-ecosystems to societal-stakeholders.
Dual-Polarized Filtering Transmitarray Antennas With Low-Scattering Characteristic

A filtering transmitarray antenna (TAA) with high-gain in-band radiations at the <inline-formula> <tex-math notation="LaTeX">$X$ </tex-math></inline-formula>-band and an out-of-band low-scattering characteristic is presented in this communication. The proposed composite TAA element consists of a dual-polarized resistive sheet, a fixed bandstop frequency-selective surface (FSS) element, and an adjustable bandpass FSS element also serving as a phase shifter. The resistive element is constructed by inserting a parallel inductor–capacitor (PLC) resonant structure into the center of a lumped-resistor-loaded metallic dipole. A transparent frequency-domain window at the center operating frequency (<inline-formula> <tex-math notation="LaTeX">$f_{c}$ </tex-math></inline-formula>) is created by the PLC resonance and is further shared by both FSS elements, hence allowing for high in-band transmission herein. At frequencies below or above <inline-formula> <tex-math notation="LaTeX">$f_{c}$ </tex-math></inline-formula>, the whole composite TAA element acts as an absorber with the bandpass or bandstop FSS elements as the ground planes for the resistive sheet, respectively. The measured results show that the composite TAA can achieve gain-filtering responses with out-of-band suppression levels ≥25 dB, ~8 dB scattering cross section (SCS) reductions in 4–7 and 14–20 GHz, and the radiation gain of 25.3 dBi simultaneously. Because of these merits, the proposed design can relieve the stress on filtering circuit designs, also offering an attractive solution in stealth technology.
Cyclin D1: A Golden Gene in Cancer, Cardiotoxicity, and Cardioprotection

Objective: Cyclin D1 is an essential protein that acts as a mitogenic sensor. In this manuscript, we discuss the importance of cyclin D1 in oncology and cardio-oncology, and we challenge the prognostic and therapeutic response values of cyclin D1 to figure out if it can be a beneficial marker. We also discuss the agents and microRNAs that can be used as a potential therapeutic approach via regulating cyclin D1 expression in oncology and cardio-oncology. Discussion: Clinical significance of cyclin D1 is defined not only in several cancers such as breast cancer, melanoma, and glioblastoma but also in cardiomyocyte regeneration and cardiac hypertrophic growth. Several studies have indicated that the injection of cardiotoxic agents such as doxorubicin (DOX) induces damage to the cardiac system and increases cyclin D expression at single injection, which might be related to DXO-mediated damage in the adult heart. However, cyclin D1 overexpression leads to hypertrophic growth of cardiomyocytes, and cyclin-dependent kinase (CDK)) inhibitors such as p16 do not inhibit the hypertrophic growth of cardiomyocytes. Thus, the reaction is CDK-independent. Conclusions: Cyclin D1 overexpression is positively correlated with tumor progression, treatment response, cardiotoxicity, and poor prognosis. Cyclin D1 expression has an important role in cardiac hypertrophy, and it can be a promising marker in monitoring cardiomyocyte treatment responses, cardioprotection, and cardiotoxicity. Finally, cyclin D1 plays an important role in hypertrophic growth of cardiomyocytes via a novel mechanism. Given all these pieces of evidence, cyclin D1 can be introduced as a favorable biomarker in future cardiology and cardio-oncology.
The Effect of Preservative Liquid Composition on Physicochemical Properties of Mozzarella Cheese

The effect of preservative liquid on the physicochemical properties of Mozzarella cheese during storage was examined. Mozzarella cheese was analyzed 2 weeks after storing in liquid composed of 0_0. 2% citric acid, 0_2% sodium chloride, and 0_1% calcium chloride dihydrate. The addition of citric acid and sodium chloride to the liquid increased the moisture content and decreased the hardness of cheese. On the other hand, cheese became harder as the calcium chloride concentration increased. Additionally, citric acid was the main cause of skin formation on the surface of cheese. These results indicate that changes in the combination and concentrations of compounds dissolved in the preservative liquid significantly influence the physicochemical properties of Mozzarella cheese. Thus, the selection of preservative liquid could be one of the important factors determining the product quality.
Effect of Bone Marrow Derived-Mesenchymal Stem Cells on Submandibular Salivary Glands of Carbimazole Induced Hypothyroidism in Albino Rats

Purpose: This study was aimed to estimate the effect of bone marrow derived mesenchymal stem cells (BM-MSCs) on the submandibular salivary gland of induced hypothyroidism in rats. Material and Methods: Thirty adult male albino rats weighing between 200-250 grams were used in the present study. The animals were divided into three equal groups: Group I (control group), Group II (carbimazole induced hypothyroidism group): Rats received a daily dose of carbimazole (5mg/250g/day) for 5 weeks, Group III (BM-MSCs treated group): Hypothyroidism was induced similar to group II, then rats were injected with 1x 107 BM-MSCs cells. All Rats were euthanized after 8 weeks (5 weeks of hypothyroidism induction + 3 weeks of stem cells injection). Results: group (II) showed excessive destruction and degenerative changes of the acini and ducts in comparison to group (I), while group (III) revealed marked improvement of the parenchymal elements after BM-MSCs injection. Conclusions: This study supposes that BM-MSCs improve salivary glands damage following induction of hypothyroidism. Therefore, BM-MSCs can be applied as cell-based therapy for restoration of hypothyroid-induced salivary hypofunction.
Advances in organic thermoelectric materials and devices for smart applications

Organic thermoelectric (OTE) materials have been considered to be promising candidates for large area and low‐cost wearable devices owing to their tailorable molecular structure, intrinsic flexibility, and prominent solution processability. More importantly, OTE materials offer direct energy conversion from the human body, solid‐state cooling at low electric consumption, and diversified functions. Herein, we summarize recent developments of OTE materials and devices for smart applications. We first review the fundamentals of OTE materials from the viewpoint of thermoelectric performance, mechanical properties and bionic functions. Second, we describe OTE devices in flexible generators, photothermoelectric detectors, self‐powered sensors, and ultra‐thin cooling elements. Finally, we present the challenges and perspectives on OTE materials as well as devices in wearable electronics and fascinating applications in the Internet of Things.
MOCVD Grown HgCdTe Heterostructures for Medium Wave Infrared Detectors

This paper presents the current status of medium-wave infrared (MWIR) detectors at the Military University of Technology’s Institute of Applied Physics and VIGO System S.A. The metal–organic chemical vapor deposition (MOCVD) technique is a very convenient tool for the deposition of HgCdTe epilayers, with a wide range of compositions, used for uncooled infrared detectors. Good compositional and thickness uniformity was achieved on epilayers grown on 2-in-diameter, low-cost (100) GaAs wafers. Most growth was performed on substrates, which were misoriented from (100) by between 2° and 4° in order to minimize growth defects. The large lattice mismatch between GaAs and HgCdTe required the usage of a CdTe buffer layer. The CdTe (111) B buffer layer growth was enforced by suitable nucleation procedure, based on (100) GaAs substrate annealing in a Te-rich atmosphere prior to the buffer deposition. Secondary-ion mass spectrometry (SIMS) showed that ethyl iodide (EI) and tris(dimethylamino)arsenic (TDMAAs) were stable donor and acceptor dopants, respectively. Fully doped (111) HgCdTe heterostructures were grown in order to investigate the devices’ performance in the 3–5 µm infrared band. The uniqueness of the presented technology manifests in a lack of the necessity of time-consuming and troublesome ex situ annealing.
The Melting and Transformation Characteristics of Minerals during Co-combustion of Coal with Different Sludges

The co-combustion of sludge and coal in the existing coal-fired power plant is a promising way for the disposal of sludge. However, slagging in boilers is one of the potential problems if the sludge was mixed improperly with coal during co-combustion. In this paper, the ash fusion characteristics and mineral transformation behavior of a bituminous coal, an industrial sludge, a municipal sludge, and their mixtures have been studied. The results showed that the ash fusion temperatures of the mixed samples show a nonlinear relationship with the proportion of sludge. It was found that the variation of the ash fusion temperature of blended samples of coal with different sludges can be effectively predicted by a ternary phase diagram. Thermal analysis indicated that the decreasing of ash fusion temperature of the blends was caused by the melting phenomenon between the original minerals in coal and sludge which formed new minerals with a low ash fusion temperature. Mineral analysis showed that the formation of d.
Aspirin Loading and Release from MCM-41 Functionalized with Aminopropyl Groups via Co-condensation or Postsynthesis Modification Methods

A comprehensive study of aspirin loading and release from MCM-41 and amine functionalized MCM-41 was conducted. Two different functionalization methods, co-condensation and postsynthesis modification, were utilized and compared. All of the MCM-41 samples were thoroughly characterized before and after aspirin loading by powder X-ray diffraction, nitrogen adsorption isotherms, and thermogravimetric analysis to determine the structure and physicochemical properties such as surface area, pore volume, and functional group loading. Molecular level details about the aspirin–MCM-41 interactions were revealed through FTIR and 13C solid-state NMR experiments. For the aminopropyl-functionalized MCM-41, the carboxylic acid group of aspirin associates with the amine group of the functionalized MCM-41. In all of the samples, an interaction between the aspirin phenyl group and the mesoporous silica host was hypothesized based on shifts in the phenyl group 13C NMR resonances. Molecular dynamics simulations supported the .
The Security Perspectives of Vehicular Networks: A Taxonomical Analysis of Attacks and Solutions

Vehicular networks are the combination of transport systems and the internet systems formed with the main motive to increase the safety of passengers, although non-safety applications are also provided by vehicular networks. Internet of Things (IoT) has a subsection called Mobile Ad hoc Network (MANET)m which in turn has a subsection called Vehicular Ad hoc Network (VANET). Internet of Energy (IoE) is a new domain that is formed using electric vehicles connected with VANETs. As a large number of transport systems are coming into operation and various pervasive applications are designed to handle such networks, the increasing number of attacks in this domain is also creating threats. As IoE is connected to VANETs extension with electric cars, the future of VANETs can be a question if security measures are not significant. The present survey is an attempt to cover various attack types on vehicular networks with existing security solutions available to handle these attacks. This study will help researchers in getting in-depth information about the taxonomy of vehicular network security issues which can be explored further to design innovative solutions. This knowledge will also be helpful for new research directions, which in turn will help in the formulation of new strategies to handle attacks in a much better way.
Differences Between Effectiveness Of Inmas Acupuncture And Local Points In Back And Shoulder Pain

Background: Shoulder pain and low back pain usually arise because of overuse or excessive use. Acupuncture can relax back muscles, waist and shoulders through cutaneosomatic reflex; and increase the release of endorphins so that it can reduce inflammation in back, waist, and shoulders so that it can help relieve pain and restore the function of back, waist, and shoulders. This study aims to determine differences betwen effectiveness of INMAS and local points acupuncture on pain and quality of life in workers with back and shoulder pain. Methods: This study is quantitative quasi experimental design with control group with pre and post test, conducted in JulySeptember 2020 at Verta Medika Acupuncture, Klaten. The population was all patients with shoulder and back pain who underwent acupuncture therapy and the sample was determined by inclusion and exclusion criteria and divided into two groups using simple random sampling. Each group consisted of 15 patients. Data analysis focused on pain scale (NRS) and quality of life (WHO-QoL). Results: INMAS technique was better at reducing pain scale (ρ = 0.001), quality of physical health (ρ = 0.083), quality of psychological health (ρ = 0,000), quality of social (ρ = 0,000), and quality of environmental health (ρ = 0.045). Conclusion: INMAS technique is more effective than local points acupuncture for reducing pain levels and it improves the quality of life. Research using larger population and sample is needed to increase validity and reliability of the study. ARTICLE HISTORY Received :February 02 th , 2021 Accepted :May 25 th , 2021
Innate and Adaptive Immune Responses Induced by A. Fumigatus Conidia and Hyphae

Purpose Previous research indicated hyphae of A. fumigatus rather than conidia could successfully build pulmonary aspergillosis model in immunocompetent mice. In this study, we compared the immune responses induced by hyphae and conidia, making a preliminary explanation for the phenomenon.Methods Macrophages and PBMCs were respectively stimulated by A. fumigatus hyphae and conidia and immunological changes were measured in vitro. Male C57BL/6 mice were challenged with conidia and hyphae through intratracheal inoculation. Dynamic conditions of mice were recorded and their immune responses were measured by RNA-seq.Results The results confirmed that hyphae could induce more intensive inflammation than conidia. However, macrophages revealed a higher production of ROS as well as M1 polarization in response to conidia stimuli. In addition, conidia could promote Th1 cell differentiation, while hyphae could increase the CD4/CD8 ratio. RNA-seq validated that multiple immunologically relevant pathways were much more strongly activated by hyphae, which also promoted Th2 cell differentiation and suppressed Th1 cell differentiation. Both hyphae and conidia could activate Th17 cell differentiation.Conclusion Conidia and hyphae induced different immune responses and the immune responses against conidia played a better protective role.
Socioeconomic disparity in regular consumption of tobacco among adults: an empirical investigation from Northeast India

Abstract Background or Objective The present study addressed the gender differential of socioeconomic disparity in the age-adjusted daily consumption of smoked tobacco, smokeless tobacco and both among the adults in North-East India, and the risk factors associated with it. Methods:We analysed data from the second round of the Indian Global Adult Tobacco Survey (2016-17). Prevalence ratio and disparity index were used to capture the socioeconomic disparity in the regular consumption of tobacco. Binary logistic regression modelswere used to estimate the risk factors associated with tobacco use. Results The study found about three out of every ten adults aged 15 years and above consume smokeless tobacco daily, whereas the prevalence of smoked tobacco consumption was less than that. This study also captured the existence of socioeconomic inequalityin the age-adjusted prevalence of daily consumption of smoked and smokeless tobacco among the study subjects, regardless of the measurement by educational level, employment and wealth status. However, the poorest and the unemployed were more prone to consume any form of tobacco as compared to less poor and employed. Conclusions Proper execution of policies that includes health education about the daily consumption of tobacco and its direct association with severe health diseases needs to be devised in the Northeastern region.
How Do Peer Awards Motivate Creative Content? Experimental Evidence from Reddit

We theorize peer awards’ effects on the volume and novelty of creative user-generated content (UGC) produced at online platform communities. We then test our hypotheses via a randomized field experiment on Reddit, wherein we randomly and anonymously assigned Reddit’s Gold Award to 905 users’ posts over a two-month period. We find that peer awards induced recipients to make longer, more frequent posts and that these effects were particularly pronounced among newer community members. Further, we show that recipients were causally influenced to engage in greater (lesser) exploitation (exploration) behavior, producing content that exhibited significantly greater textual similarity to their own past (awarded) content. However, because the effects were most pronounced among new community members, who also produce content that, in general, is systematically more novel than that of established members to begin with, this process yields a desirable outcome: larger volumes of generally novel UGC for the community. This paper was accepted by Chris Forman, information systems.
HER-3 Expression and MEK Activation in Non-small Cell Lung Cancer

BackgroundHER-3 has a role in pathogenesis and development of resistance to targeted therapies in non-small cell lung cancer (NSCLC). MethodsWe analysed tumour samples from 45 patients with adenocarcinoma of the lung. HER-3 and HER-2 expression was identified using immunohistochemistry as well as bioinformatic interrogation of The Cancer Genome Atlas (TGCA). ResultsHER-3 was highly expressed in 42.2% of cases and observed more frequently than HER-2 overexpression. ERBB3 copy number alone did not account for HER-3 overexpression. Bioinformatic analysis of TCGA demonstrated that MEK activity score (a score of downstream pathway activity and surrogate of functional HER-3 signalling) did not correlate with HER-3 ligands. EGFR pathway signalling was predominant with a significantly positive correlation of EGFR and AREG expression with MEK activity score. In the ERBB3 expressed group, ERBB3 RNA expression levels were significantly correlated with MEK activity score. ERBB3 expression level remained highly positively correlated with MEK activity after adjusting for EGFR expression. ConclusionHER-3 expression is common and it is not associated with gene amplification nor is it ligand dependent. HER-3 is an alternative pathway to EGFR activating MEK. HER-3 is a potential therapeutic target in NSCLC by virtue of frequent overexpression and functional downstream signalling.
A generalized economic model for optimally selecting forecasted load profiles for measuring demand response in residential energy management system

To forecast the demand response of a residential customer, forecasted load profiles must first be calculated and the demand response produced by residential energy management devices determined. Finding an efficient method to select an optimal forecasted load profile to assess the demand response of these devices is a fundamental issue currently overlooked. Poorly forecasted load profiles can affect customer compensation for demand reduction, estimation of retail profits and allocation and reconciliation processes for electricity markets. This research resolved to develop an economic model for selecting an optimal forecasted load profile from which the demand response of residential energy management devices can be determined. Using 2 years of half‐hourly electricity consumption data for 5379 households obtained from the “Low Carbon” London project (UK), a novel economic model was created to assess the economic advantage of nine different forecast methods. Results suggest that when creating forecasted load profiles to measure demand response of these devices the sociodemographic of customers, tariff type and the operational objectives of the device must be taken into account to maximize the economic benefit of demand response initiatives for the customer and retailer.