Miracle-dz/UniFAR-FTUs huggingface dataset:
LINC00518 Promotes Cell Malignant Behaviors via Influencing EIF4A3-Mediated mRNA Stability of MITF in Melanoma

Melanoma has become the most severe sort of skin cancer, deriving from the pigment-producing melanocytes. Existing research has validated that long noncoding RNAs (lncRNAs) have critical function in the progression of cancers. LINC00518 has been studied in cutaneous melanoma; however, the molecular mechanism of LINC00518 in melanoma needs in-depth investigation. In our study, LINC00518 was revealed to be upregulated in melanoma tissues and cells, and melanoma patients in high LINC00518 expression group had poorer prognosis as depicted in GEPIA database. Functional assays revealed that LINC00518 depletion inhibited cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT). Furthermore, MITF was confirmed to be upregulated in melanoma tissues and cells, and melanoma patients in high MITF expression group had poorer prognosis as displayed in GEPIA database. MITF expression was positively connected to LINC00518 expression. Additionally, results of mechanism assays uncovered EIF4A3 could bind with LINC00518 and MITF, and LINC00518 recruited EIF4A3 to stabilize MITF mRNA. Finally, it was demonstrated that upregulation of MITF could partially abrogate the inhibitory impact of LINC00518 knockdown on melanoma cell malignant behaviors. To summarize, LINC00518 promotes the malignant processes of melanoma cells through targeting EIF4A3/MITF axis, which might provide novel potential biomarkers for melanoma prognosis.
A Formal Verification for Kantorovitch's Theorem

Kantorovitch's theorem gives sufficient conditions for the convergence of Newton's method. We present a full formalization of this theorem in the case of a real function. The work is accomplished inside the Coq proof assistant and it is based on the Reals library provided by the theorem prover. For the general case of the theorem we first describe a way to represent concepts from multivariate analysis, as Coq does not offer such a library. We then discuss the proof of Kantorovitch's theorem based on this representation.
Results of Open Reduction and Internal Fixation of Proximal Third Both Bones of Forearm Fractures in Adults

Background : For displaced proximal fractures of the forearm in the adult, open reduction and internal fixation with plating is usually considered as the best therapeutic option. Objective : Improving functional outcome of patients with proximal third both bones forearm fracture in adults. Patients and Methods: At Orthopedic Department of Zagazig University Hospital 12 patients with proximal third both bones of forearm fractures in adults were studied in prospective research. Open reduction and internal fixation through dynamic compression plate were done to all patients. Results: the average operation time among the studied group were (59.8±6.8) minutes ranged from 30 to 95 minutes. Only one case, which had infection, had delayed union (19 weeks), which was treated by antibiotics, otherwise the average union time for all cases was (13.7±2.5) weeks and there was no un-union. Most of the studied group (66.7%) had excellent Mayo elbow performance index followed by (16.7%) had good score then fair and poor (8.3%) for each. There was statistically significant higher AO classification among poor and fair outcome than excellent and good outcome as (100.0%) of poor and fair outcome were A2. Conclusion : Open reduction and internal fixation (ORIF) is appropriate treatment of both bones forearm fracture. Plate fixation was safe and effective treatment option for proximal both bones forearm fracture because it provided good function outcomes.
Democratic decline in the EU and its effect on democracy promotion in Central Asia

Abstract We know surprisingly little about the impact of democratic decline in the EU on foreign policy and on democracy promotion efforts in particular. We examine qualitative and quantitative changes in aid allocation for democracy promotion alongside declining levels of democracy in the EU and its members. Focusing on decision-makers’ perspectives, we explain these changes with strategic and constructivist approaches. We analyse multilateral and bilateral aid flows from the EU and its members to Central Asia with data from OECD and IATI from 2000 to 2018. We identify quantitative changes in aid promoting democracy in Central Asia, which can be partially attributed to the donors’ increasing challenges for democracy at home. While the overall aid levels remained stable, we also identify qualitative shifts in allocation patterns favouring government institutions rather than civil society organisations. Our findings address the impact of democratic decline on foreign policy towards non-democratic states outside the European neighbourhood.
Thermal Annealing Effects of V2O5 Thin Film as an Ionic Storage Layer for Electrochromic Application

A vanadium pentoxide (V2O5) thin film with thermal annealing as an ionic storage layer for electrochromic devices is presented in our study. The V2O5 thin film was deposited on an ITO glass substrate by an RF magnetron sputtering. The electrochromic properties of the film were evaluated after various thermal annealing temperatures. The structural analysis of the film was observed by X-ray diffraction (XRD), field emission electron microscopy (FE-SEM), and atomic force microscopy (AFM). The structure of the V2O5 thin film transformed from an amorphous to polycrystalline structure with directions of (110) and (020) after 400 °C thermal annealing. The electrochromic properties of the film improved compared with the unannealed V2O5 thin film. We obtained a charge capacity of 97.9 mC/cm2 with a transparent difference ΔT value of 31% and coloration efficiency of 6.3 cm2/C after 400 °C thermal annealing. The improvement was due to the polycrystalline orthorhombic structure formation of V2O5 film by the rearrangement of atoms from thermal energy. Its laminate structure facilitates Li+ ion intercalation and increases charge capacity and transparent difference.
An Online Condition Monitor Method for IGBT Independent of Collector Current

Junction temperature monitoring and fault diagnosis of power semiconductor devices can provide critical information to ensure the reliable operation of power electronic systems. In this article, an online condition monitoring method for insulated gate bipolar transistors (IGBTs), which is not affected by the collector current, is proposed based on the Miller voltage plateau of the conduction process. The relationship between the Miller voltage plateau and the junction temperature is analyzed, and an analytical model of the Miller voltage against junction temperature is established. By using this model and the conducting-state characteristics of the device, a reverse current phase measuring strategy is proposed to decouple the influence of the collector current on the junction temperature estimation, and an online measurement circuit of the Miller voltage is designed. In addition, the characteristics of the trigger voltage under different faults are analyzed to recognize fault types. The experimental results show that the proposed method has high sensitivity and good linearity. It is proven that the proposed measurement strategy is independent of the collector current, which can accurately distinguish the fault forms of IGBTs.
Fertility-Sparing Surgery versus Radical Hysterectomy in Early Cervical Cancer: A Propensity Score Matching Analysis and Noninferiority Study

Objective: Fertility-sparing surgery (FSS) is the treatment of choice for patients with early cervical cancer (ECC) and fertility desire, but survival rates compared to radical hysterectomy (RH) have been scarcely reported. The aim of this study was to analyse the oncological outcomes of FSS compared to a balanced group of standard RH. Methods: A retrospective multicentre study of ECC patients who underwent FSS or RH was carried out in 12 tertiary hospitals in Spain between January 2005 and January 2019. The experimental group included patients who underwent a simple and radical trachelectomy, and the control group included patients who underwent RH. Optimal 1:1 propensity score (PS) matching analysis was performed to balance the series. Results: The study included 222 patients with ECC; 111 (50%) were treated with FSS, and 111 (50%) were treated with RH. After PS matching, a total of 38 patients in the FSS group and 38 patients in the RH group were analysed. In both groups, the overall survival (HR 2.5; CI 0.89, 7.41) and recurrence rates (28.9% in the FSS group vs. 13.2% in RH group) were similar. The rate of disease-free survival at 5 years was 68.99% in the FSS group and 88.01% in the RH group (difference of −19.02 percentage points; 95% CI −32.08 to −5.96 for noninferiority). In the univariate analysis, only tumour size reached statistical significance. Conclusion: FSS offers excellent disease-free and overall survival in women with ECC with fertility desire and is not inferior compared to RH.
Fabrication of a Double Core–Shell Particle-Based Magnetic Nanocomposite for Effective Adsorption-Controlled Release of Drugs

There has been very limited work on the control loading and release of the drugs aprepitant and sofosbuvir. These drugs need a significant material for the control of their loading and release phenomenon that can supply the drug at its target site. Magnetic nanoparticles have characteristics that enable them to be applied in biomedical fields and, more specifically, as a drug delivery system when they are incorporated with a biocompatible polymer. The coating with magnetic nanoparticles is performed to increase efficiency and reduce side effects. In this regard, attempts are made to search for suitable materials retaining biocompatibility and magnetic behavior. In the present study, silica-coated iron oxide nanoparticles were incorporated with core–shell particles made of poly(2-acrylamido-2-methylpropane sulfonic acid)@butyl methacrylate to produce a magnetic composite material (MCM-PA@B) through the free radical polymerization method. The as-prepared composite materials were characterized through Fourier-transform infrared (FTIR)spectroscopy, scanning electron microscopy (SEM), X-ray diffraction analysis (XRD), energy-dispersive X-Ray Analysis (EDX), and thermogravimetric analysis (TGA), and were further investigated for the loading and release of the drugs aprepitant and sofosbuvir. The maximum loading capacity of 305.76 mg/g for aprepitant and 307 mg/g for sofosbuvir was obtained at pH 4. Various adsorption kinetic models and isotherms were applied on the loading of both drugs. From all of the results obtained, it was found that MCM-PA@B can retain the drug for more than 24 h and release it slowly, due to which it can be applied for the controlled loading and targeted release of the drugs.
Exploring nuance in both experience and adaptation: Commentary on Titone and Tiv (2022)

The keynote article by Titone and Tiv (2022) represents a key step forward in characterizing and quantifying bilingual experience, and how this may be leveraged to examine neurocognitive outcomes. The framework takes a novel multi-leveled approach to capturing and describ-ing language experience. The first level handles the direct language use dynamics of a given individual or ego-driven language dynamics. Beyond the individual or ego is the level of inter-personal language dynamics – that is, the dynamic situations of interaction one is faced with. These interactions are guided (at least in part) by ecological/societal language dynamics – over-arching trends and conditions at the community and societal level which set parameters on the nature of language dynamics and interaction in the ego ’ s environment. Finally, although not directly discussed within the paper, temporal dynamics – that is, dynamic shifts and trends of language experience across time – of language use sit at the outermost level. Bilingual experience is truly a multidimensional spectrum with a number of experiences that condition its outcomes and the framework proposed by the authors provides a basis for better capturing the levels of social context which condition an individual ’ s opportunities for engagement. However, neurocognitive adaptations to these experiences are also a multidimensional spectrum and these too need to be better linked to the dynamicity of bilingual language experience. Bilingual experience consists of a series of cognitive demands all revolving around the man-agement and control of multiple active competing
Simulation of English Speech Recognition Based on Improved Extreme Random Forest Classification

Existing speech recognition systems are only for mainstream audio types; there is little research on language types; the system is subject to relatively large restrictions; and the recognition rate is not high. Therefore, how to use an efficient classifier to make a speech recognition system with a high recognition rate is one of the current research focuses. Based on the idea of machine learning, this study combines the computational random forest classification method to improve the algorithm and builds an English speech recognition model based on machine learning. Moreover, this study uses a lightweight model and its improved model to recognize speech signals and directly performs adaptive wavelet threshold shrinkage and denoising on the generated time-frequency images. In addition, this study uses the EI strong classifier to replace the softmax of the lightweight AlexNet model, which further improves the recognition accuracy under a low signal-to-noise ratio. Finally, this study designs experiments to verify the model effect. The research results show that the effect of the model constructed in this study is good.
Rancang Bangun Sistem Pendataan Request Lagu dari Program Acara di RRI Medan Berbasis Website

Di era globalisasi semua kegiatan telah mengalami perubahan terutama dalam bidang komunikasi. Salah satu perkembangan teknologi komunikasi yaitu adanya radio, salah satu radio milik negara yaitu RRI Medan. Dengan radio terdapat acara hiburan yaitu acara pemutaran lagu, dimana para pendengar dapat melakukan request lagu. Maka dari itu, dibuatlah sebuah sistem untuk mendata request lagu yang diberikan oleh pendengar. Dimana dalam pengembangan sistem menggunakan metode waterfall yaitu model pengembangan sistem yang setiap perkembangannya harus melalui susunan yang teratur. Tahapan tersebut harus diselesaikan terlebih dahulu sebelum ke tahap berikutnya.sistem ini menggunakan UML (Unified Modelling Language) yang merupakan suatu pemodelan yang mampu memberikan uraian secara rinci dalam sebuah analisa serta memberikan kebutuhan yang diperlukan oleh sebuah sistem seperti penulisan kelas dalam bahasa program, perincian database serta komponen yang dibutuhkan dalam sistem hasil pembahasan mengenai perancangan dan pembuatan Sistem ini, dapat ditarik kesimpulan bahwa system pendataan request lagu berbasis website ini merupakan program komputer yang dirancang untuk membantu memanajemen suatu program acara di radio agar terkomputerisasi. Dengan adanya sistem ini akan mempermudah admin dan staff untuk mendata acara program radio yang terdapat polling request lagu.
Loxin Reduced the Inflammatory Response in the Liver and the Aortic Fatty Streak Formation in Mice Fed with a High-Fat Diet

Oxidized low-density lipoprotein (ox-LDL) is the most harmful form of cholesterol associated with vascular atherosclerosis and hepatic injury, mainly due to inflammatory cell infiltration and subsequent severe tissue injury. Lox-1 is the central ox-LDL receptor expressed in endothelial and immune cells, its activation regulating inflammatory cytokines and chemotactic factor secretion. Recently, a Lox-1 truncated protein isoform lacking the ox-LDL binding domain named LOXIN has been described. We have previously shown that LOXIN overexpression blocked Lox-1-mediated ox-LDL internalization in human endothelial progenitor cells in vitro. However, the functional role of LOXIN in targeting inflammation or tissue injury in vivo remains unknown. In this study, we investigate whether LOXIN modulated the expression of Lox-1 and reduced the inflammatory response in a high-fat-diet mice model. Results indicate that human LOXIN blocks Lox-1 mediated uptake of ox-LDL in H4-II-E-C3 cells. Furthermore, in vivo experiments showed that overexpression of LOXIN reduced both fatty streak lesions in the aorta and inflammation and fibrosis in the liver. These findings were associated with the down-regulation of Lox-1 in endothelial cells. Then, LOXIN prevents hepatic and aortic tissue damage in vivo associated with reduced Lox-1 expression in endothelial cells. We encourage future research to understand better the underlying molecular mechanisms and potential therapeutic use of LOXIN.
Total flavonoids of Rhizoma Drynariae enhances CD31hiEmcnhi vessel formation and subsequent bone regeneration in rat models of distraction osteogenesis by activating PDGF-BB/VEGF/RUNX2/OSX signaling axis

Total flavonoids of Rhizoma Drynariae (TFRD), extracted from the kidney-tonifying Traditional Chinese medicine Rhizoma Drynariae, can be effective in treating osteoporosis, bone fractures and defects. However, the pharmacological effects of TFRD on the specific vessel subtype CD31hiEmcnhi during distraction osteogenesis (DO) remains unclear. The present study aimed to investigate the effects of TFRD on CD31hiEmcnhi vessels in a rat model of DO. In the present study, tibial DO models were established using 60 rats with a distraction rate of 0.2 mm per day for 20 days. Co-immunofluorescence staining of CD31 and endomucin (Emcn) was conducted to determine CD31hiEmcnhi vessels. Radiographic, angiographic and histological analyses were performed to assess bone and vessel formation. Tube formation, alkaline phosphatase (ALP) and Von Kossa staining assays were performed to test angiogenesis of endothelial precursor cells (EPCs) and osteogenesis of bone marrow-derived mesenchymal stem cells (BMSCs). Additionally, expression levels of platelet-derived growth factor (PDGF)-BB, VEGF, runt-related transcription factor 2 (RUNX2) and Osterix (OSX) were determined by western blotting and reverse transcription-quantitative PCR. The in vivo assays demonstrated that TFRD markedly promoted CD31hiEmcnhi vessel formation during DO, whereas PDGF-BB neutralizing antibody suppressed vessel formation. Furthermore, the ALP, Von Kossa staining and tube formation assays indicated that TFRD notably elevated the angiogenic capacity of EPCs and osteogenic capacity of BMSCs under stress conditions, which was significantly suppressed by blocking PDGF-BB. The protein and mRNA levels of PDGF-BB, VEGF, RUNX2 and OSX were upregulated by TFRD, but downregulated by blocking PDGF-BB. Thus, TFRD could facilitate CD31hiEmcnhi vessel formation and subsequently enhance angiogenic-osteogenic coupling to regenerate bone defects during DO via the PDGF-BB/VEGF/RUNX2/OSX signaling axis, which indicated that CD31hiEmcnhi vessels could be a potential novel therapeutic target for DO, and TFRD may represent a promising drug for promoting bone regeneration in DO by increasing CD31hiEmcnhi vessels.
Accident Detection in Autonomous Vehicles Using Modified Restricted Boltzmann Machine

Accident detection in autonomous vehicles could save lives by reducing the time it takes for information to reach emergency responder. One of the most common reason for the death of humans is accident. Indeed, it was determined throughout the survey that road accidents are indeed the second greatest cause of death in the United States for people aged 30 to 44 years, representing for 1/3 among all deaths. The transportation industry is increasingly relying on mathematical methods and new data assets to detect injuries. Many machine learning and deep learning models have already been proposed for accident detection but still there is much space for further improvement to be done to save human lives in case of accident detection, if accidents are not identified well. In our present study, we proposed modified restricted Boltzmann machine for accident detection. Our proposed methodology consists of the following steps. In the first step, we took different accidental and nonaccidental images as an input. In the second step, we applied our proposed deep learning technique modified restricted Boltzmann machine. In the third step, when weight acceleration and coefficient adjustments are run as a generalization mechanism, then we check our model performance after applying through multiple procedures. As a result, multiple images are classified as accidental and nonaccidental images of vehicles. Proposed methodology has been applied for data set, and data have been divided into different training and testing ratios. The proposed MRBM model has an accuracy of 98% in classification of both accidental and nonaccidental images of vehicles. The proposed model outperforms the competition significantly than other in which they are compared like artificial neural network, support vector machine, and restricted Boltzmann machine techniques.
Biochemical and Toxicological Effects of Emamectin Bonzoate against Spodoptera littoralis (Boisd.) (Lepidoptera: Noctuidae)

damaging pest of ABSTRACT The cotton leaf worm, Spodoptera littoralis (Boisd.) is a key pest of cotton and a wide range of economically important crops, vegetables, and fruits in Egypt and worldwide. Emamectin benzoate is a broad-spectrum bioinsecticide that has long been used to control lepidopteran pests such as S. littoralis . The toxicity of emamectin benzoate against S. littoralis fourth-instar larvae and its biochemical effects on their acetylcholinesterase (AChE), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were determined. The toxicity of emamectin benzoate against larvae of S. littoralis was increased by the increase of exposure time. The LC 50 values (lethal concentrations causing 50% larval mortality) caused by emamectin benzoate against S. littoralis larvae were 8.8×10 -2 , 1.1×10 2 and 4.8×10 -3 ppm a.i. at 2, 3 and 4 DAT, respectively. Overall, the application of emamectin benzoate on larvae at concentrations of 4.8×10 -4 , 9.6×10 -4 and 2.4×10 -3 ppm a.i. (concentrations equivalent to 10, 20 and 50% of the estimated LC 50 value at 4 DAT, respectively) increased the activity of AChE, AST, ALT of the treated larvae. The increase rate in the activity of those enzymes was dependent on both the concentration and exposure time for emamectin benzoate.