Miracle-dz/UniFAR-FTUs huggingface dataset:
Studies on eosinophil leucocyte migration. II. Factors specifically chemotactic for eosinophils and neutrophils generated from guinea-pig serum by antigen-antibody complexes.

Chemotactic activity for eosinophils and neutrophils has been studied using guinea-pig serum activated by preformed antigen–antibody complexes. Rabbit complexes or complexes prepared either with guinea-pig IgG2 or IgG1 were equally capable of generating a heat stable activity from guinea-pig serum that was chemotactic for guinea-pig eosinophils and for neutrophils of both the guinea-pig and the rabbit. This was distinguished from a relatively heat-labile chemotactic activity present in untreated guinea-pig serum. The heat-stable complex-mediated chemotactic activity was thought to be complement dependent since chemotaxis for eosinophils or neutrophils could not be generated from heated serum, ammonia treated serum or from serum treated with complexes in the presence of 0·01 M EDTA. Guinea-pig sera, activated either with rabbit, guinea-pig IgG1 or IgG2 complexes, was fractionated by sucrose-density gradient ultracentrifugation and by Sephadex chromatography. In all experiments two peaks of cell specific chemotactic activity could be separated. The peak of activity for guinea-pig neutrophils was approximately 4·5S and in the fractionation range of proteins having a molecular weight of between 65,000 and 85,000. The peak of guinea-pig eosinophil chemotactic activity was 1·5S–2S and in the molecular weight range of between 15,000 and 20,000. Those fractions which were chemotactic for guinea-pig neutrophils did not attract rabbit neutrophils. Rabbit neutrophils migrated towards those fractions of guinea-pig serum chemotactic for guinea-pig eosinophils; therefore, the properties associated with guinea-pig eosinophil chemotactic activity were similar to previously published data for a fragment cleaved from the 5th component of complement.
Molecular characterization of myostatin in black seabream, Acanthopagrus schlegelii

Myostatin is a negative regulator of skeletal muscle growth and has a potential application in aquaculture. The black seabream myostatin gene was cloned and sequenced. It had three exons encoding a protein of 382 amino acids. A 90 bp 5′-untranslated region (UTR) and a 536 bp 3′-UTR were obtained by RACE. Four microsatellite sequences, a (CAG)9, a (TC)12, a (CA)16 repeat and an “imperfect” (CA)25 microsatellite, were found in the myostatin. Two introns were 329 and 742 bp in length, respectively. The deduced amino acid sequence of the myostatin had a putative amino terminal signal sequence, a TGF-β propeptide domain, a RXXR proteolytic processing site, a TGF-β domain, and 12 conserved cysteine residues. The myostatin gene was expressed in four of the examined ten tissues and organs. The expression of myostatin was the strongest in the skeletal muscle and brain, intermediate in the eye, and low in the heart.
Effects of Dihydroergotamine on Intracranial Pressure, Cerebral Blood Flow, and Cerebral Metabolism in Patients Undergoing Craniotomy for Brain Tumors

In a search for a nonsurgical intervention to control intracranial hypertension during craniotomy, the authors studied the effects of dihydroergotamine on mean arterial blood pressure (MABP), intracranial pressure (ICP), cerebral perfusion pressure (CPP), cerebral blood flow (CBF), and cerebral metabolism in patients who underwent craniotomy for supratentorial brain tumors. Twenty patients were randomized to receive either dihydroergotamine 0.25 mg intravenously or placebo as a bolus dose during craniotomy. Anesthesia was induced with thiopental/fentanyl/atracurium, and maintained with isoflurane/N2O/fentanyl at normocapnia. After removal of the bone flap and exposure of intact dura, ICP was measured subdurally and dihydroergotamine/placebo was administered. Intracranial pressure and MABP were measured continuously. Cerebral blood flow (after intravenous administration of 133Xe) and arteriojugular venous difference of oxygen (AVDO2) were measured before, and 30 minutes after, dihydroergotamine/placebo administration. Cerebral metabolic rate of oxygen (CMRO2) was calculated. After administration of dihydroergotamine, a significant increase in MABP from 74 to 87 mm Hg (median) and CPP from 65 to 72 mm Hg (median) were found. Simultaneously to the increase in MABP, a significant increase in ICP from 9.5 to 11.5 mm Hg (median) was disclosed, whereas no significant differences in CBF, AVDO2, or CMRO2 were found. Intracranial pressure was significantly higher after dihydroergotamine than after placebo. In conclusion, no ICP decreasing effect of a bolus dose of dihydroergotamine was found when administered to patients with brain tumors during isoflurane/N2O anesthesia. Corresponding increases in MABP and ICP suggest that abolished cerebral autoregulation might explain why dihydroergotamine was associated with an ICP increase.
Synchronization and Compensation in TDM Based Single RF MIMO-OFDM System

In this paper, an approach of time division multiplexing (TDM) for the MIMO-OFDM (orthogonal frequency division multiplexing) transmitter and receiver is studied and evaluated to reduce the power consumption and cost down of the multiple antenna RF chains. With this TDM technique, our proposed MIMO-OFDM communication system can reduce the number of RF chains from N to 1, which significantly reduces the overall cost and size of the MIMO-OFDM system. However, synchronization problem like the carrier frequency offset (CFO) and sample timing offset (STO) is serious. So we solve the synchronization problem to compensate the CFO and STO. Finally, simulation results demonstrate that the single RF MIMO-OFDM communication system almost can provide the same diversity gain as the multiple RF chain MIMO systems.
CDRnN: A high performance chemical-disease recognizer in biomedical literature

Diseases/Chemical play central roles in many areas of biomedical research and healthcare. Consequently, aggregating the disease knowledge and treatment research reports becomes an extremely critical issue, especially in rapid-growth knowledge bases (e.g., PubMed). Thus, a framework of disease/chemical named entity recognition and normalization has become increasingly important for biomedical text mining. In this work, we not only define five diversities of disease names but also develop a system for disease/chemical mention recognition and normalization in biomedical texts. Our system utilizes an order 2 conditional random fields (CRFs) model to develop a recognition system and optimize the results by customizing several post-processing, including abbreviation resolution, consistency improvement, stopwords filtering, and adjectives reorganization. After evaluation, we obtained the best performance (86.9% of F-score) on disease normalization and (89.95% of Precision) on chemical normalization. These results suggest that our system is a high-performance and state of the art recognition system for disease/chemical recognition and normalization from biomedical literature.
Study of bias in antenatal clinic HIV-1 surveillance data in a high contraceptive prevalence population in sub-Saharan Africa

Objective To describe patterns, sources and consequences of bias in antenatal clinic (ANC) HIV prevalence estimates in a high contraceptive prevalence population. Background HIV surveillance in Africa relies on data from pregnant women attending ANCs. HIV estimates from pregnant women understate female infection levels in low income, high fertility populations. Bias in high contraceptive use, delayed sexual debut populations remains undescribed. Design and method Comparison of parallel cross-sectional population and antenatal survey data from rural Zimbabwe, where 60% of women are recent contraceptive users. Results HIV prevalence in recently pregnant women (25.7%; n = 576) and all women (25.5%; n = 5138) is similar over the age-range 15–44 years. As in high fertility populations, HIV prevalence is higher in pregnant women at young ages and lower at older ages but the crossover point occurs later due to delayed sexual activity. HIV understatement at older ages due to HIV-associated infertility is mitigated by less HIV infection and less frequent ANC attendance in contraceptive users. The local ANC HIV prevalence estimate is lower [21.2%; n = 1215; risk ratio versus pregnant women in the general population, 0.8; 95% confidence interval (CI), 0.7–1.0], possibly because women from more remote areas are included. ANC estimates overstate the relative risk of HIV in more educated women (age-adjusted odds ratio, 1.1; 95% CI, 0.8–1.4 versus 0.7; 95% CI, 0.6–0.9). Conclusions ANC estimates understate female HIV prevalence in this low fertility population but, here, the primary cause is not selection of pregnant women. ANC estimate adjustment procedures that control for contraceptive use and age at first sex are needed.
Automatic feature selection based motor imagery movements detection scheme from EEG signals in the Dual Tree Complex Wavelet Transform domain

An automatic feature selection based classification scheme in the Dual Tree Complex Wavelet Transform (DTCWT) domain from electroencephalogram (EEG) signals has been presented in this study to identify left and right hand imagery movements. First, the EEG epochs are decomposed into different real and imaginary coefficient bands and then, some statistical features like norm entropy and mean absolute deviation (MAD) have been calculated. These features are combined into a single feature space and after that optimal features have been selected automatically imposing some feature selection criteria from this combined feature space. The selected features have been justified as suitable to classify different kinds of motor imagery EEG signals by statistical hypothesis testing (e.g., one way ANOVA) and graphical analyses (e.g., scatter plots). Finally, K-nearest neighbor (kNN) based classifiers are developed using these selected features for classifying 2 types of imagery hand movements. 90.36% overall accuracy is achieved in publicly available BCI competition II Graz data set which is shown to be superior than several existing methods.
Damage Identification Methods for Support Position of Tower Structure Based on Information Extension

This paper provides one damage identification method for support position of tower structure based on dynamic response information extension. On the basis of obtaining dynamic response information of tower structure under environment excitation, wavelet transform is adopted for structure damage location identification. When there is damage in the support of tower structure, dynamic response information of upper structure cannot show the space domain information of the support position. Therefore, through effective extension of dynamic response information, at the same time of eliminating the Gibbs Phenomenon on the boundary of initial dynamic response information interval, damage identification of support position is achieved. Analysis result of examples shows that this method is very effective and reliable for damage identification of support position of tower structure.
Viruses infecting the marine Prymnesiophyte Chrysochromulina spp.: isolation, preliminary characterization and natural abundance

Sixty-four natural virus communities were concentrated from seawater collected from 3 locations in Texas (USA) coastal waters (Gulf of Mexico, 27" 31' N, 96" 18' W; Aransas Pass, 27" 50' N, 97" 02' W; Laguna Madre, 27' 30' N, 97' 18' W) and screened for the presence of lytic pathogens which infect the marine Prymnesiophyte (Haptophyte) Chrysochromuljna brevifilum. Viruses were detected in 16 of the samples and ranged in abundance from 2 to 688 infectious units 1-' The pathogens were detected at the 3 locations, but not on all dates, from December through June when water temperatures were less than 28°C. A clonal isolate of the virus (CbV-PW1) was obtained by determining the concentration of the infectious agent by a most-probable-number assay and adding 0.2 of an infective unit into each of 20 exponentially growing cultures, removing an aliquot from a culture which lysed and repeating the procedure. The isolate also caused lysis of C. strobllus, but did not lyse 8 other isolates of Chrysochromulina or 5 other genera of Prymnesiophytes that were screened. The double-stranded DNA virus is a polyhedron of about 145 to 170 nm in diameter with a heavily staining central region that is distinct from the capsid. The appearance of the virions is associated with a granular region in the cytoplasm that does not appear within uninfected cells. Ultimately, viral production results in disruption of the organelles, lysis of the cell and release of the virus particles. Although the number of viruses produced per lytic event is presently unknown we have counted more than 320 virus particles in a single ultrathin section of an infected cell. These results suggest that viruses are likely important in regulating Chrysochromulina populations in the sea and may be the reason that blooms of the genus are relatively rare and ephemeral.
A Nurse-Led Multidisciplinary Intervention to Improve Cardiovascular Disease Profile of Patients

The aim of this study was to evaluate the impact of a structured screening and nurse-based intervention on cardiovascular risk factors. In patients with established cardiovascular disease, a cardiovascular risk profile was assessed, and lifestyle was evaluated by using an automated questionnaire. A multidisciplinary team proposed an integral individualized plan of care on the basis of these assessments. During follow-up, a nurse-led lifestyle intervention program and the best medical treatment were offered. A total of 328 outpatients were included. After screening, a follow-up term of at least 1 year was reached in 176 patients (59.9%). Low-density lipoprotein cholesterol and systolic blood pressure were significantly reduced. A reduction in the amount of smoking, alcohol consumption, and unhealthy eating habits was observed. However, the amount of physical activity was unaffected, and body mass was increased. A structural evaluation of cardiovascular risk factors and an integrated nurse-led approach can successfully reduce risk in cardiovascular patients.
Impact of quantitatively determined native thoracic aortic tortuosity on endoleak development after thoracic endovascular aortic repair.

OBJECTIVE The objective of our study was to assess whether there is an association between native thoracic aortic curvature and the development of endoleaks after thoracic endovascular aortic repair. MATERIALS AND METHODS Quantitative analysis of the native aortic lumen was performed on preprocedural CT angiograms of 40 patients with thoracic aortic aneurysm treated by thoracic endovascular aortic repair. The curvature of the median centerline was measured. Tortuosity indexes were calculated on the basis of the sum of the curvature values within the diseased segment and in the proximal and distal fixation zones. The association between the tortuosity index and endoleak was analyzed. RESULTS Compared with patients without endoleaks, the tortuosity index of the proximal fixation zone was higher in patients with type Ia endoleak (9.5 vs 1.5 cm(-1), p < 0.01); the tortuosity index of the distal fixation zone was higher in type Ib endoleak patients (6.6 vs 0.5 cm(-1), p < 0.05); and the tortuosity indexes of the proximal fixation zone and of the diseased segment were higher in type III endoleak patients (11.0 vs 1.5 cm(-1), p < 0.01; and 15.8 vs 7.2 cm(-1), p < 0.01, respectively). Patients with a type III endoleak had longer diseased segments and larger mean diameters of the aneurysm than patients without endoleaks (148.6 vs 87.1 mm, p < 0.01; and 75.4 vs 63.2 mm, p < 0.05, respectively). Logistic regression analysis revealed that the risk of a type I or type III endoleak increased as the tortuosity index increased, with a 90% risk of endoleak at a tortuosity index of 10 cm(-1) in the proximal fixation zone. CONCLUSION Quantification of aortic tortuosity using CT angiograms may help to predict whether an endoleak will develop after thoracic endovascular aortic repair, and this quantification method may become an important tool for risk stratification before thoracic endovascular aortic repair.
Compensator-Free Mixed-Ripple Adaptive On-Time Controlled Boost Converter

A mixed-ripple adaptive on-time controlled boost converter is proposed. With the proposed control method, the compensator network is no longer required. Hence, the chip area and cost can be reduced, and a satisfied load regulation still can be achieved. Besides, a novel on-time generator is proposed to fix the switching frequency in continuous conduction mode (CCM). Moreover, a differential difference comparator is proposed to simplify the circuits and further reduce chip area. Furthermore, with the proposed control, the converter is capable of smoothly switching between discontinuous conduction mode and CCM, depending on the loading condition. The proposed boost converter was implemented by using a 0.18- $\mu \text{m}$ 1P6M mixed-signal process, and the chip area is 0.88 mm2. The input voltage may range from 0.8 to 1.4 V, the output voltage is set to 1.8 V, and the measured peak efficiency is 92.4%.
Transphyletic conservation of developmental regulatory state in animal evolution

Specific regulatory states, i.e., sets of expressed transcription factors, define the gene expression capabilities of cells in animal development. Here we explore the functional significance of an unprecedented example of regulatory state conservation from the cnidarian Nematostella to Drosophila, sea urchin, fish, and mammals. Our probe is a deeply conserved cis-regulatory DNA module of the SRY-box B2 (soxB2), recognizable at the sequence level across many phyla. Transphyletic cis-regulatory DNA transfer experiments reveal that the plesiomorphic control function of this module may have been to respond to a regulatory state associated with neuronal differentiation. By introducing expression constructs driven by this module from any phyletic source into the genomes of diverse developing animals, we discover that the regulatory state to which it responds is used at different levels of the neurogenic developmental process, including patterning and development of the vertebrate forebrain and neurogenesis in the Drosophila optic lobe and brain. The regulatory state recognized by the conserved DNA sequence may have been redeployed to different levels of the developmental regulatory program during evolution of complex central nervous systems.
Toxicity of pharmaceutical wastewater on male reproductive system of Mus musculus

This study reports on the toxic effects of 35-days intragastric perfusion of pharmaceutical wastewater on the male reproductive system of Mus musculus. Flow cytometric analyses and staining with fluorescein diacetate (FDA) and propidium iodide (PI) were used to assess the toxicity on spermatogenic cells. Significant depletions in the relative percentages of elongated spermatid (HC), diploid spermatogonia (2C), and S-phase cells were observed. These alterations in different germ cell populations were reflected in the various germ cell ratios. The ratios of 1C : 4C and HC : 2C showed a significant decline after pharmaceutical wastewater treatment, while the 4C : 2C and 1C : 2C ratios increased significantly. FDA and PI staining displayed reduced viability of spermatogenic cells in wastewater treated group. Statistically significant percentages of sperm abnormalities showed the genotoxic potential of this pharmaceutical wastewater. Testicular histopathological studies of treated animals revealed expansion of interstitial space and reduction in the number and size of Leydig cells. Thus, the present study has established the toxicity of pharmaceutical wastewater on the reproductive biology of male mice. Toxicology and Industrial Health 2007; 23: 47—54.
Noise suppression approach with the BV-L1 nonlinear image decomposition

In a digital camera, several factors cause signal-dependency of additive noise. Many denoising methods have been proposed, but many of them do not necessarily work well for actual signal-dependent noise. To solve the problem of removing signal-dependent noise of a digital color camera, this paper presents a denoising approach via nonlinear image-decomposition. As a pre-process, we employ the BV-L1 nonlinear image-decomposition variational model. This variational model decomposes an input image into three components: a structural component corresponding to a cartoon image approximation collecting geometrical image features, a texture component corresponding to fine image textures, and a residual component. Each separated component is denoised with a denoising method suitable to it. For an image taken with a digital color camera under the condition of high ISO sensitivity, the BV-L1 model removes its signal-dependent noise to a large extent from its separated structural component, in which geometrical image features are well preserved, but the structural component sometimes suffers color-smear artifacts. To remove those color-smear artifacts, we apply the sparse 3D transform-domain collaborative filtering to the separated structural component. On the other hand, the texture component and the residual component are rather contaminated with noise, and the effects of noise are selectively removed from them with our proposed color shrinkage denoising schemes utilizing inter-channel color crosscorrelations. Our method achieves efficient denoising and selectively removes signal-dependent noise of a digital color camera.
A Simplified Electromagnetic-thermal Analysis of Human Exposure to Radiation from Base Station Antennas

Electromagnetic-thermal analysis of the human body exposed to base station antennas radiation is presented in this paper. The formulation of the problem is based on a simplified cylindrical representation of the human body. Electromagnetic part of the analysis involves incident and internal field dosimetry, while the thermal model deals with the bio-heat transfer processes in the body. The electric field induced in the body is determined through the corresponding axial current induced in the body. This current distribution along the body is obtained by solving the Pocklington integral equation for a thick cylinder. The Pocklington integral equation is solved numerically via the Galerkin-Bubnov Boundary Element Method (GB-BEM). Once the internal electric field and related total absorbed power in the human body is obtained, it is possible to calculate a corresponding temperature rise in the body due to the GSM exposure. This temperature rise is determined by solving the bio-heat transfer equation via the conventional finite element method (FEM).