Miracle-dz/UniFAR-FTUs huggingface dataset:
Adenine Nucleotides Chemotaxis of Rat Mast Cells Toward

Rat mucosal mast cells express P2 purinoceptors, occupation of which mobilizes cytosolic Ca 2 1 and activates a potassium conductance. The primary function of this P2 system in mast cell biology remains unknown. Here, we show that extracellular ADP causes morphological changes in rat bone marrow-cultured mast cells (BMMC) typical of those occurring in cells stimulated by chemotaxins, and that the nucleotides ADP, ATP, and UTP are effective chemoattractants for rat BMMC. ADP was also a chemotaxin for murine J774 monocytes. The nucleotide selectivity and pertussis toxin sensitivity of the rat BMMC migratory response suggest the involvement of P2U receptors. Poorly hydrolyzable derivatives of ADP and ATP were effective chemotaxins, obviating a role for adenosine receptors. Buffering of external Ca 2 1 at 100 nM or reduction of the electrical gradient driving Ca 2 1 entry (by elevating external K 1 ) blocked ADP-driven chemotaxis, suggesting a role for Ca 2 1 inﬂux in this process. Anaphylatoxin C5a was a potent chemotaxin (EC 50 ’ 0.5 nM) for J774 monocytes, but it was inactive on rat BMMC in the presence or absence of laminin. Ca 2 1 removal or elevated [K 1 ] had modest effects on C5a-driven chemotaxis of J774 cells, implicating markedly different requirements for Ca 2 1 signaling in C5a- vs ADP-mediated chemotaxis. This is supported by the observation that depletion of Ca 2 1 stores with thapsigargin completely blocked migration induced by ADP but not C5a. These ﬁndings suggest that adenine nucleotides liberated from parasite-infested tissue could participate in the recruitment of mast cells by intestinal mucosa. The Journal of Immunology, 1999, 163: 970–977.
E -recruitment Adoption among Chinese Job-Seekers

China has the second largest economy in the world, and businesses in the country are robust. In line with technological changes, businesses have also been fast in adopting newer technological or digital trends. One of these trends is E-recruitment. Data gathered from 404 randomly selected Chinese respondents were analyzed using structural equation modeling to identify the factors involved in the process leading to E-recruitment adoption. The multi-stage analysis results indicated that outcome expectation positively affects perceived usefulness of E-recruitment, while internet self-efficacy affects perceive ease of use. In turn, both perceived usefulness and perceived ease of use influence behavioral intention to use E-recruitment. The findings and recommendations provide valuable insights on the adoption of E-recruitment and its implications in modern businesses.
A Low-Cost Virtual Coach for Diagnosis and Guidance in Baseball/Softball Batting Training

—Baseball and softball are popular sports worldwide. In baseball/softball, batting is a fundamental action, but it is also one of the most difﬁcult skills to master. Batting requires constant practice and proper guidance. Experienced coaches can provide instant diagnoses and feedbacks tailored for individual players. In the absence of such coaches, tools such as motion tracking systems or sports bracelets may help to assist the players. Unfortunately, they are either too expensive and awkward to use, or too limited in providing useful diagnosis and guidance. In this paper, we introduce a low-cost diagnosis and guidance tool for batting training in baseball/softball. The tool requires only one wearable device and one camera, such as the one on the smartphone, to capture the player’s motion. The collected data are summarized and analyzed to derive the distinct features of the player’s actions in different swing stages. The tool then pinpoints the mistakes and discrepancies in player’s batting actions by comparing with expert actions, which in turn guides the player to perfect the action. Evaluations on real users show the effectiveness of our tool in comparison with experienced coaches.
A Model for Facial Activity Recognition using Metarepresentation: a Concept

—Recognition of the facial visual properties (physiognomy) and its static and dynamic behavioral patterns (action units) has proved to be an important part in many multimedia retrieval and analysis applications. Apart from the previous studies, where methods to extract part of the action units from an image or video have been developed, in this ongoing research project we work on a model for more accurate and detailed facial activity semantic description adaptable to new behavioral patterns and real conditions. In this paper, we address challenges of building this model and suggest its basic multilevel concept. On the low level, we propose using wavelet-based multiresolution representation of video data. On the middle level, several multiclass classifiers are being examined for the purpose of attribute learning, and a custom multiple metric is provided. On the high level, facial elements, behavioral patterns and their attributes can be connected and further extended using the ontologically-compliant architecture of this model. On the abstraction layer, all three levels of this model are seamlessly integrated via graph-based hierarchies of metavertices, metaedges and their mappings. Having this structure, the proposed model can be trained and employed to solve the problems of human behavior retrieval and human-computer multimodal interaction more efficiently. Current results, however, reveal that to be reliable, this model requires further research studies and their comprehensive experimental evaluation.
GLOBAL STABILITY OF AN INFECTION AND VACCINATION AGE-STRUCTURED MODEL WITH GENERAL NONLINEAR INCIDENCE

In this paper, a model structured in vaccination and infection ages with a general class of nonlinear incidence is introduced and investigated. The resulting model is a system of two age-structured PDEs and an ODE with a non local term. We give a necessary and sufﬁcient condition for global asymptotic stability of the free-equilibrium related to the basic reproduction number. Further, by constructing a new Lyapunov functional, we show the global asymptotic stability of the endemic equilibrium whenever it exists. Finally, a discussion about controlling the spread of the disease is provided.
Running-head: Roosting behaviour in brood parasitic cowbirds 2 Roosting behaviour is related to reproductive strategy in brood parasitic 3 cowbirds 4

Shiny Cowbirds Molothrus bonariensis and are closely related brood parasites, but the former is socially polygynous or promiscuous 15 and an extreme host generalist, while the latter is socially monogamous and 16 parasitizes almost exclusively one host. Females of both species lay in relative 17 darkness, before dawn, relying for host nest location on previous days’ prospecting 18 activity, or possibly on following better-informed roost associates. We studied the 19 temporal and spatial patterns of roosting behaviour in these species to test the 20 hypothesis that roosting behaviour of cowbirds is related to their breeding strategy 21 (brood parasitism) and reflects differences in strategies between species. We 22 recorded fidelity to a roost, location fidelity within a roost, inter-individual spatial 23 associations, and timing of roost departures and parasitic events, using tagged 24 individuals. Female Shiny Cowbirds and both sexes of Screaming Cowbirds showed 25 marked fidelity in roosting location, and roost departures occurred both during and 26 after the known time window for parasitism, with earlier departures probably 27 corresponding to laying days. Screaming Cowbird females and males that were 28 trapped together and showed high levels of association during the day also showed 29 high levels of association in the roost. We describe the spatial and temporal patterns 30 of a relatively poorly known aspect of avian ecology in general and of brood 31 parasites’ behaviour in particular. 32
Human- b -defensins-1-3 and analogs do not require proton motive force for antibacterial activity against Escherichia coli

Human- b -defensins 1-3 (HBD-1-3) and their C-terminal analogs Phd-1-3 do not show antibacterial activity against Escherichia coli in the presence of mono-and divalent cations. Activity of peptides was examined against E. coli pretreated with carbonyl cyanide m-chlorophenylhydrazone (CCCP) and salt remedial Escherichia coli ftsEX, a deletion mutant of FtsEX complex [an ATP-binding cassette (ABC) transporter protein], in the presence of Na + , Ca 2+ , and Mg 2+ . Activity was observed in the presence of Na + and Ca 2+, although not in the presence of Mg 2+ against E. coli, when proton motive force (PMF) was dissipated by CCCP. The peptides exhibited antibacterial activity against E. coli ftsEX even in the presence of Na + and Ca 2+ . Our results indicate that HBD-1-3 and Phd-1-3 do not require PMF for their antibacterial activity. The absence of activity against E. coli in the presence of Na + and Ca 2+ ions is due to not only weakened electrostatic interactions with anionic membrane components, but also involvement of electrochemical gradients. However, Mg 2+ prevents electrostatic interaction of the peptides with the outer membrane resulting in loss of activity.
OTT_A_244351 3335..3346

Riping Wu* Qiaolian Li* Fan Wu Chunmei Shi Qiang Chen 1Fujian Medical University Union Hospital, Fuzhou, Fujian Province, People’s Republic of China; 2Fujian Medical University, Fuzhou, Fujian Province, People’s Republic of China; 3Fujian Medical University Union Hospital, Fuzhou, Fujian Province, People’s Republic of China, Stem Cell Research Institute, Fujian Medical University, Fuzhou, Fujian Province, People’s Republic of China
Expression of Follistatin and Inhibin/Activin Subunit Genes in Porcine Follicles'

Expression of the follistatin (FS) and inhibin/activin (I/A) a, pA, and p,1 subunit genes in porcine ovarian follicles was eval- uated by reverse transcriptase polymerase chain reaction and/or RNase protection procedures to establish changes during the final stages of follicular development. For the I/A ot and 13P subunits, expression increased (p < 0.05) as follicles progressed to the mid-stage of the follicular phase. The p3, subunit was expressed in lower concentrations, and all three I/A subunits showed a marked reduction (p < 0.01) in expression by the late stage of follicular development. In contrast to this pattern, FS gene expression decreased (p < 0.05) as follicles developed from the early (low estradiol) to the mid stage (high estradiol) and continued to decline in advanced follicles (after estrus). The predominant mRNA encoded for FS-315, and the ratio of mRNA for FS-315 to mRNA for FS-288 did not differ significantly during the three stages. Within an animal, concentration of FS mRNAs was related more to stage of the follicular phase than to follicular size. Follicular fluid concentration of FS changed in a manner similar to that observed for expression of its gene. We conclude that expression of the FS gene and translation of its mRNA decrease as follicles approach ovulatory status.
Towards Developer-and task-tailored navigation models

Developers spend a substantial amount of their time navigating source code to locate the places which are relevant for the task at hand. Current recommendation approaches that support a developer in this costly activity, accentuate diﬀerent aspects of code structure or a developer’s interaction to infer the elements a developer might want to navigate to next. While some recommendation approaches use models that, for instance, focus predominantly on the source code topology, such as method call relations, others focus on the frequency and recency of previously visited code elements. All of these approaches generally use the same underlying model throughout the change task session, regardless of the speciﬁc developer or the type of change task. Thus, they have the implicit premise that developers’ information needs and navigation behaviour stays the same over time and across developers and tasks. In on our research on developers’ navigation, we saw, however, that a developer’s navigation behaviour varies a lot over the course of a change task and across developers. This suggests that a model that dynamically adapts to the developer’s navigation behaviour and information needs could provide much better support in recommending relevant elements to developers. The goal of the presented work is to investigate how a developer’s information needs and navigation behaviour change over the course of a change task. With a better understanding, we will be able to develop recommendation models that better tailor the recommendations to the developer and the tasks and thus provide more relevant recommendations.
Erythropoietin induces homeostatic plasticity at hippocampal synapses. Cerebral Cortex

30 The cytokine erythropoietin (EPO) is the master regulator of erythropoiesis. 31 Intriguingly, many studies have shown that the cognitive performance of patients 32 receiving EPO for its hematopoietic effects is enhanced, which prompted the growing 33 interest in the use of EPO-based strategies to treat neuropsychiatric disorders. EPO 34 plays key roles in brain development and maturation, but also modulates synaptic 35 transmission. However, the mechanisms underlying the latter have remained elusive. 36 Here, we show that acute (40-60 min) exposure to EPO presynaptically downregulates 37 spontaneous and afferent-evoked excitatory transmission, without affecting basal firing 38 of action potentials. Conversely, prolonged (3h) exposure to EPO, if followed by a 39 recovery period (1h), is able to elicit a homeostatic increase in excitatory spontaneous, 40 but not in evoked, synaptic transmission. These data lend support to the emerging view 41 that segregated pathways underlie spontaneous and evoked neurotransmitter release. 42 Furthermore, we show that prolonged exposure to EPO facilitates a form of 43 hippocampal long-term potentiation (LTP) that requires non-canonical recruitment of 44 calcium-permeable AMPA receptors (CP-AMPARs) for its maintenance. These 45 findings provide important new insight into the mechanisms by which EPO enhances 46 neuronal function, learning and memory. 47 48 49 50 52
HELP ME RELAX! BIOFEEDBACK AND GAMIFICATION TO IMPROVE INTERACTION DESIGN IN HEALTHCARE

Biofeedback represents a new frontier in emotion design. Game design and more recently gamification are proving to be valuable design approaches to increasing fun, pleasurability and wellbeing, particularly in healthcare applications. Moreover, healthcare applications may be significantly improved from designs that incorporate elements of biofeedback and gamification. This paper describes the results of a user study aimed to assess the design potential of combining biofeedback and gamification techniques as a way to improve the user experience. We examined performance and stress levels of ten participants while playing Relaxing Rhythms, a biofeedback game. The results demonstrate the need to design more emotionally compelling healthcare user experiences using biofeedback and gamification techniques. However, as our study shows, mixing gamification with wellbeing applications requires careful attention to how the game is designed as well as even if users perceive it as a game for solving health issues, like negative stress.
Métodos de valoración del estado nutricional

This review article aims to describe and detail the fundamental aspects necessary to perform an adequate nutritional diagnosis in health and disease, at the individual or population level. This can only be achieved with the application of validated methods allowing the classification of malnutrition, both in a quantitative or qualitative point of view. It also allows the categorization of its severity by the use and interpretation of indicators, e.g. anthropometric, biochemical, dietetic, clinical and functional dimension of the nutritional status, all valued in the context of the distinct characteristics throughout the life cycle, from the new-born to the elderly. Nutritional evaluation of individuals or groups of individuals is a key area in health care, thus the integration of differentiated and trained nutrition professionals is mandatory. An appropriate utilization of nutritional assessment methods and techniques requires both scientific knowledge and development of a critical mindset for their selection, application and inter-relation in specific situations. It is also of utmost importance to develop studies in the different countries of Iberoamerica, in order to adapt guidelines of weight gain during pregnancy, including nutritional status before conception, to the begging of the pregnancy until the end of the gestation period.
Bias in the evaluation of evidence linking depression to

nificant heterogeneity within the plaques. Secondly, the atheromatous plaque is considered as solid rather than a biologic material with completely different properties being difficult to be interpreted by the Newton’s Law which is valid for inorganic solids and liquids. Physics suggest that any dynamic change of the measurement conditions, most important of all being the blood flow, reduces the heat transferred to the sensing element (thermistor) leading to underestimation of plaque temperature. Therefore, by blood flow obstruction this limitation is eliminated and in addition the influence of friction locally is avoided. In the clinical setting, we need to know whether an increase of temperature is indicative of a hot plaque with inflammatory involvement. The current data from experimental4 and clinical3 studies showed that there is correlation between thermal heterogeneity and macrophage content. A discrepancy however between ex vivo3;4 and in vivo plaque temperature measurements is observed. The ‘cooling effect’ of blood flow leading to underestimation of the temperature measurements is a potential interpretation for this discrepancy. In our study2 there is a criticism from the authors regarding the complete attachment of the thermistor to the atherosclerotic plaque and the possible effect of normal saline at 37 C used for balloon inflation that may had affected the measurements. However, in a study8 from our institution with a balloonthermography catheter, which ensures the full attachment of the thermistor to the plaque by inflation of the balloon by carbon dioxide, similar results were found without the mentioned possible limitations. Additionally, from our experience temperature is not increased in all lesions, in which complete interruption of flow is accomplished. Thus by flow interruption more reliable temperature measurements are obtained. Diamantopoulos et al. recently presented their experience in an atheromatic porcine model and they observed that plaques with an increase of temperature during blood flow interruption had higher macrophage concentration.9 This study documented that by complete interruption of flow the real temperature of atheromatous plaque is approximated and the inflammatory substrate is identified. Interestingly, these results do not support the hypothesis that flow reduction threatens the accuracy of intravascular thermography,1 but instead that by flow obstruction we approximate the real plaque temperature. Finally, we have to recognize that temperature measurements are influenced by several biological and mechanical factors and we need more studies in our search for the pathophysiologic insights of plaque heat generation.
Integration on Quantum Euclidean Space and Sphere in N Dimensions

Invariant integrals of functions and forms over q - deformed Euclidean space and spheres in N dimensions are defined and shown to be positive definite, compatible with the star- structure and to satisfy a cyclic property involving the D- matrix of SOq(N). The definition is more general than the Gaussian integral known so far. Stokes theorem is proved with and without spherical boundary terms, as well as on the sphere.
Al 2 O 3 surface passivation characterized on hydrophobic and hydrophilic c- Si by a combination of QSSPC, CV, XPS and FTIR

In this work, the influence of the c- Si surface finishing (hydrophobic/hydrophilic) prior to the deposition of the Al 2 O 3 passivation layer on the passivation quality is investigated. The samples are characterized by a combination of Quasi-Steady-State-PhotoConductance (QSSPC) Capacity-Conductance (CV), X-ray Photoelectron Spectroscopy (XPS) and Fourier Transformed InfraRed (FTIR) measurements. Furthermore, FTIR measurements are used to determine the thickness of interfacial SiO x layer.
EFFECT OF CLUTURE MEDIA AND MINERAL NPK FERTILIZATION ON THE PRODUCTION OF F. benjamina AND F. hawaii TRANSPLANTS UNDER GREEN HOUSE CONDITIONS

This experiment was conducted at the Experimental Station of Vegetable and Floriculture Department, Faculty of Agriculture, Mansoura University under green house conditions during the two successive seasons of 2010 and 2011 to study the effect of different culture media and levels of mineral NPK fertilization and their interaction on vegetative growth and chemical composition of Ficus benjamina and Ficus hawaii transplants grown in pots. Four culture media were tested (peat, peat moss + perlite, peat moss + sand and peat moss + perlite +sand). Each medium received three levels of NPK fertilizer (0, 2 or 4 g/pot). Regarding the effect of culture media, the obtained results indicated that Ficus benjamina transplants grown in the medium of peat moss+perlite+sand induced the highest values for plant height (cm), number of leaves per plant and number of branches per plant in the first season, while in the second one, the values of these characters were higher when the transplants grown in the medium of peat and perlite. NPK concentrations (%) in the leaves increased in both seasons when F. benjamina transplants grown in the culture medium of peat moss+perlite+sand, while the highest values of total chlorophyll content (mg/g fresh weight) in leaves were recorded in the transplants grown in the medium of peat and sand in both seasons. For Ficus hawaii , the highest data for plant height (cm), number of leaves and number of branches per plant were recorded when the transplants were grown in the culture medium of peat+perlite+sand in the first season, while in the second one, the best results in plant height and number of leaves/plant were when the transplants were planted in peat+perlite medium and received 4 g/pot NPK. In case of Ficus hawaii , the transplants grown in peat moss+perlite+sand medium gave the best results in plant height, number of leaves and branches per plant when received 4 g/pot NPK in the first season. In the second one, the transplants fertilized with 4 g/pot NPK showed the best results in plant height and number of leaves per plant when grown in peat moss+sand medium and the highest value in number of branches per plant when grown in peat moss+perlite+sand medium. The superiority in N, P and K percentages as well as total chlorophyll content (mg/g fresh weight) for both plant species in both seasons was for the interaction treatment of moss+perlite+sand culture medium plus fertilization with 4 g/pot NPK. According to the aforementioned results, it could be recommended under conditions of the present research to use peat moss+perlite+sand (1:1:1 by volume) as a culture medium for Ficus benjamina and Ficus hawaii transplants in combination with NPK fertilizer (20:20:20) at the rate of 2 or 4 g/plant.