Miracle-dz/UniFAR-FTUs huggingface dataset:
Home Dialysis Among Elderly Patients: Outcomes and Future Directions

Elderly patients who receive home dialysis (peritoneal dialysis or home hemodialysis) may have reduced survival compared to younger patients. Therefore, it is important to ascertain the goals of home dialysis in the elderly rather than simply fixate on standard metrics such as technique survival. As Canada’s population continues to age, the prevalence of end-stage kidney disease among the elderly population is increasing. Patients with multiple comorbidities are now surviving long enough to be started on dialysis. Although home dialysis has been associated with better survival and improved quality of life, its impact on the frail and elderly populations require further elucidation. Home dialysis patients can either independently perform tasks or have support in the home to safely conduct dialysis. Moreover, patients burdened with frailty and multiple comorbidities who lack support in the home may not be able to perform home dialysis safely. Innovative strategies to improve accessibility to home-based therapies need further exploration. In addition, the concept of goal-directed dialysis promotes more individualized treatment. Future continuous quality improvement initiatives must examine if goal-directed dialysis leads to better quality of life outcomes in the elderly.
Cognitive, Regulatory, and Interpersonal Mechanisms of HIV Stigma on the Mental and Social Health of Men Who Have Sex With Men Living With HIV

Public stigma surrounding HIV is related to heightened emotional distress, poor psychological functioning, and reduced subjective well-being in people living with HIV. For men who have sex with men (MSM) living with HIV, they may also face stigmatizing attitudes within the gay community, which create an additional burden to their health. Grounded in the psychological mediation framework, the present study examined the underlying psychological processes through which HIV stigma from the public and within the gay community influences the mental and social health of MSM living with HIV. Findings from 206 Chinese MSM living with HIV in Hong Kong indicated that negative self-concept, maladaptive coping, and peer isolation mediated the effect of HIV stigma on mental and social health. The study revealed the cognitive, regulatory, and interpersonal processes underlying HIV stigma and health. Feeling intense HIV stigma from the public and within the gay community may render MSM living with HIV more vulnerable to negative self-concept, maladaptive coping, and peer isolation, which contribute to poor mental and social health. To combat prejudice and discrimination against people living HIV, stigma reduction initiatives should be implemented not only in the public, but also in the gay community. Cognitive-behavioral interventions can also be used to restructure negative self-beliefs and build adaptive emotion regulation skills, which can improve stigma-related health outcomes among MSM living with HIV.
Excited state intramolecular proton transfer in hydroxyanthraquinones: Toward predicting fading of organic red colorants in art

The chemical structure of red dye affects response to light, helping to understand fading and inform protection of works of art. Compositionally similar organic red colorants in the anthraquinone family, whose photodegradation can cause irreversible color and stability changes, have long been used in works of art. Different organic reds, and their multiple chromophores, suffer degradation disparately. Understanding the details of these molecules’ degradation therefore provides a window into their behavior in works of art and may assist the development of improved conservation methods. According to one proposed model of photodegradation dynamics, intramolecular proton transfer provides a kinetically favored decay pathway in some photoexcited chromophores, preventing degradation-promoting electron transfer (ET). To further test this model, we measured excited state lifetimes of substituted gas-phase anthraquinones using high-level theory to explain the experimental results. The data show a general structural trend: Anthraquinones with 1,4-OH substitution are long-lived and prone to damaging ET, while excited state intramolecular proton transfers promote efficient quenching for hydroxyanthraquinones that lack this motif.
The Pupillary Response to the Unknown: Novelty Versus Familiarity

Object recognition is a type of perception that enables observers to recognize familiar shapes and categorize them into real-world identities. In this preregistered study, we aimed to determine whether pupil size changes occur during the perception and recognition of identifiable objects. We compared pupil size changes for familiar objects, nonobjects, and random noise. Nonobjects and noise produced greater pupil dilation than familiar objects. Contrary to previous evidence showing greater pupil dilation to stimuli with more perceptual and affective content, these results indicate a greater pupil dilation to stimuli that are unidentifiable. This is consistent with the relative salience of novelty compared to familiarity at the physiological level driving the pupil response.
Identification of hub genes and molecular mechanisms in infant acute lymphoblastic leukemia with MLL gene rearrangement

Infant acute lymphoblastic leukemia (ALL) with the mixed lineage leukemia (MLL) gene rearrangement (MLL-R) is considered a distinct leukemia from childhood or non-MLL-R infant ALL. To detect key genes and elucidate the molecular mechanisms of MLL-R infant ALL, microarray expression data were downloaded from the Gene Expression Omnibus (GEO) database, and differentially expressed genes (DEGs) between MLL-R and non-MLL-R infant ALL were identified. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were carried out. Then, we constructed a protein-protein interaction (PPI) network and identified the hub genes. Finally, drug-gene interactions were mined. A total of 139 cases of MLL-R infant ALL including 77 (55.4%) fusions with AF4, 38 (27.3%) with ENL, 14 (10.1%) with AF9, and 10 (7.2%) other gene fusions were characterized. A total of 236 up-regulated and 84 down-regulated DEGs were identified. The up-regulated DEGs were mainly involved in homophilic cell adhesion, negative regulation of apoptotic process and cellular response to drug GO terms, while down-regulated DEGs were mainly enriched in extracellular matrix organization, protein kinase C signaling and neuron projection extension GO terms. The up-regulated DEGs were enriched in seven KEGG pathways, mainly involving transcriptional regulation and signaling pathways, and down-regulated DEGs were involved in three main KEGG pathways including Alzheimer’s disease, TGF-beta signaling pathway, and hematopoietic cell lineage. The PPI network included 297 nodes and 410 edges, with MYC, ALB, CD44, PTPRC and TNF identified as hub genes. Twenty-three drug-gene interactions including four up-regulated hub genes and 24 drugs were constructed by Drug Gene Interaction database (DGIdb). In conclusion, MYC, ALB, CD44, PTPRC and TNF may be potential bio-markers for the diagnosis and therapy of MLL-R infant ALL.
Factors Influencing the Detection of Spatially-Varying Surface Gloss

In this study, we investigate the ability of human observers to detect spatial inhomogeneities in the glossiness of a surface and how the performance in this task depends on several context factors. We used computer-generated stimuli showing a single object in three-dimensional space whose surface was split into two spatial areas with different microscale smoothness. The context factors were the kind of illumination, the object’s shape, the availability of motion information, the degree of edge blurring, the spatial proportions between the two areas of different smoothness, and the general smoothness level. Detection thresholds were determined using a two-alternative forced choice (2AFC) task implemented in a double random staircase procedure, where the subjects had to indicate for each stimulus whether or not the surface appears to have a spatially uniform material. We found evidence that two different cues are used for this task: luminance differences and differences in highlight properties between areas of different microscale smoothness. While the visual system seems to be highly sensitive in detecting gloss differences based on luminance contrast information, detection thresholds were considerably higher when the judgment was mainly based on differences in highlight features, such as their size, intensity, and sharpness.
Three Optimized Methods for In Situ Quantification of Progenitor Cell Proliferation in Embryonic Kidneys Using BrdU, EdU, and PCNA

Background: Nephron progenitor cells derived from the metanephric mesenchyme undergo a complex balance of self-renewal and differentiation throughout kidney development to give rise to the mature nephron. Cell proliferation is an important index of progenitor population dynamics. However, accurate and reproducible in situ quantification of cell proliferation within progenitor populations can be technically difficult to achieve due to the complexity and harsh tissue treatment required of certain protocols. Objective: To optimize and compare the performance of the 3 most accurate S phase–specific labeling methods used for in situ detection and quantification of nephron progenitor and ureteric bud cell proliferation in the developing kidney, namely, 5-bromo-2’-deoxyuridine (BrdU), 5-ethynyl-2’-deoxyuridine (EdU), and proliferating cell nuclear antigen (PCNA). Methods: Protocols for BrdU, EdU, and PCNA were optimized for fluorescence labeling on paraformaldehyde-fixed, paraffin-embedded mouse kidney tissue sections, with co-labeling of nephron progenitor cells and ureteric bud with Six2 and E-cadherin antibodies, respectively. Image processing and analysis, including quantification of proliferating cells, were carried out using free ImageJ software. Results: All 3 methods detect similar ratios of nephron progenitor and ureteric bud proliferating cells. The BrdU staining protocol is the lengthiest and most complex protocol to perform, requires tissue denaturation, and is most subject to interexperimental signal variability. In contrast, bound PCNA and EdU protocols are relatively more straightforward, consistently yield clear results, and far more easily lend themselves to co-staining; however, the bound PCNA protocol requires substantive additional postexperimental analysis to distinguish the punctate nuclear PCNA staining pattern characteristic of proliferating cells. Conclusions: All 3 markers exhibit distinct advantages and disadvantages in quantifying cell proliferation in kidney progenitor populations, with EdU and PCNA protocols being favored due to greater technical ease and reproducibility of results associated with these methods.
Awareness and Current Therapeutics of Asthma

Introduction: Asthma is a serious allergic disorder of the respiratory system. It affects about 300 million people worldwide. This has a great burden on medical treatment. Several medicines are available, but they have many serious side effects. Therefore, there is a need to search for a new therapeutic agent with no or minimal side effects while most economical for patients. In folk medicine, antiasthmatics herbal medicine has been used and showed potential therapeutic antiasthmatic efficacy due to the presence of potential bioactive compounds. Methods: Different databases were searched (ie, Embase, PubMed, CBM, AMED, and CINAHL). We have reviewed the published data of the last 20 years. We used MeSH terms “asthma” herbal treatment of asthma, allopathic treatment of asthma, and treatment strategies for asthma. The traditional medicine was compared with modern medicine and the same pharmacotherapies alone or with placebo. The methodology was evaluated by using the GRADE summary of Finding tables and Cochrane Risk of Bias Tool. Results: There have been some clear-cut indications toward the recognition of further molecular and cellular mechanisms of asthma. Most of them recommend a further target for treatment. The novel procedures, biologics, and pharmaceuticals are evaluated. Both allopathic and herbal treatments of asthma are effective. Due to none or lesser side effects, herbal medicines are safer than conventional medicine. Conclusion: The preliminary documentation of the plants discussed in the review show the presence of several secondary metabolites that are responsible for the management of asthma and its relevant complications. Further research studies are needed to identify the bioactive compounds from these plants that have potential efficacy to cure asthma, and clinically based studies are needed to search for a complete cure for this disease.
The Targeted Therapies Era Beyond the Surgical Point of View: What Spine Surgeons Should Know Before Approaching Spinal Metastases

In the last few years, the treatment of spinal metastases has significantly changed. This is due to the advancements in surgical technique, radiotherapy, and chemotherapy which have enriched the multidisciplinary management. Above all, the field of molecular biology of tumors is in continuous and prosperous evolution. In this review, the molecular markers and new approaches that have radically modified the chemotherapeutic strategy of the most common metastatic neoplasms will be examined together with clinical and surgical implications. The experience and skills of several different medical professionals are mandatory: an interdisciplinary oncology team represents the winning strategy in the treatment of patients with spinal metastases
Non-Hermitian topological light steering

How to define a light path topologically Controlling the flow of light in a robust and flexible manner will be critical for the development of the next generation of photonic integrated devices. Exploiting the inherent protection afforded by topology, topological photonics provides a solution for the robust propagation of light. Devices so far, however, have been fixed in their functionality. Zhao et al. created light paths that can be arbitrarily switched on and off by optical illumination. Propagation can be topologically steered along desired pathways by manipulating regions of gain and loss within the photonic structure through optical excitation. This approach provides a route to controlling topologically protected light paths in an integrated optical platform. Science, this issue p. 1163 Topologically protected light paths can be controlled through optical illumination. Photonic topological insulators provide a route for disorder-immune light transport, which holds promise for practical applications. Flexible reconfiguration of topological light pathways can enable high-density photonics routing, thus sustaining the growing demand for data capacity. By strategically interfacing non-Hermitian and topological physics, we demonstrate arbitrary, robust light steering in reconfigurable non-Hermitian junctions, in which chiral topological states can propagate at an interface of the gain and loss domains. Our non-Hermitian–controlled topological state can enable the dynamic control of robust transmission links of light inside the bulk, fully using the entire footprint of a photonic topological insulator.
Building mountain biodiversity: Geological and evolutionary processes

Mountain regions are unusually biodiverse, with rich aggregations of small-ranged species that form centers of endemism. Mountains play an array of roles for Earth’s biodiversity and affect neighboring lowlands through biotic interchange, changes in regional climate, and nutrient runoff. The high biodiversity of certain mountains reflects the interplay of multiple evolutionary mechanisms: enhanced speciation rates with distinct opportunities for coexistence and persistence of lineages, shaped by long-term climatic changes interacting with topographically dynamic landscapes. High diversity in most tropical mountains is tightly linked to bedrock geology—notably, areas comprising mafic and ultramafic lithologies, rock types rich in magnesium and poor in phosphate that present special requirements for plant physiology. Mountain biodiversity bears the signature of deep-time evolutionary and ecological processes, a history well worth preserving.
Microparticules membranaires au cours des états septiques graves : aspects cellulaires, physiopathologiques et cliniques

Ce travail porte sur le role des microparticules procoagulantes (MPs) generees par les cellules vasculaires en reponse a un etat septique. Apres une introduction rappelant la structure et les proprietes des microparticules et la reponse del’hote a un agent pathogene, en particulier en terme d’activation de la coagulation, nous rapportons nos travauxexperimentaux et cliniques. Le premier travail a ete realise sur un modele cellulaire de vesiculation induite par le LPS. Il nous a permis de caracteriser le transfert du complexe CD14/TLR4 a differents types cellulaires in-vitro depourvus du recepteur au LPS. Ainsi, les MPs monocytaires pourraient avoir un role d’amplification de la reponse inflammatoire mais aussi dans la reponse anti-inflammatoire secondaire en participant a l’apoptose lymphocytaire. Le second travail aete realise chez l’animal. Apres induction d’un choc septique, nous avons observe une amelioration hemodynamique enreponse a la perfusion de proteine C activee associee a une modulation du phenotype des MPs. Reinjectees a des ratsnaifs, les MPs issues des rats septiques traites par proteine C activee developpaient une moindre vasoplegie. Enfin, nous avons realise une etude prospective sur 100 patients en choc septique. Nous avons ainsi pu caracteriser la presence d’une concentration elevee de microparticules procoagulantes, avec une variation phenotypique en presence de coagulation intravasculaire disseminee (CIVD) : reduction du contingent plaquettaire au profit des MPs d’origine leucocytaires qui deviennent preponderantes et temoignent d’une activation leucocytaire accrue, et surtout une activation des cellules endotheliales avec generation de MPs porteuses d’endogline (CD105). En analyse multivariee,CD105+-MPs etaient fortement associee a la CIVD et pourraient constituer un marqueur precoce de l’atteinte endotheliale au cours du choc septique.
Risk of natalizumab-associated PML in patients with MS is reduced with extended interval dosing

Objective To use the large dataset from the Tysabri Outreach: Unified Commitment to Health (TOUCH) program to compare progressive multifocal leukoencephalopathy (PML) risk with natalizumab extended interval dosing (EID) vs standard interval dosing (SID) in patients with multiple sclerosis (MS). Methods This retrospective cohort study included anti-JC virus antibody-positive patients (n = 35,521) in the TOUCH database as of June 1, 2017. The effect of EID on PML risk was evaluated with 3 planned analyses using Kaplan-Meier methods stratified by prior immunosuppressant use. Risk of PML was analyzed by Cox regression adjusted for age, sex, prior immunosuppressants, time since natalizumab initiation, and cumulative number of infusions. Results This study included 35,521 patients (primary analysis: 1,988 EID, 13,132 SID; secondary analysis: 3,331 EID, 15,424 SID; tertiary analysis: 815 EID, 23,168 SID). Mean average dosing intervals were 35.0 to 43.0 and 29.8 to 30.5 days for the EID and SID cohorts, respectively. Hazard ratios (95% confidence intervals) of PML risk for EID vs SID were 0.06 (0.01–0.22, p < 0.001) and 0.12 (0.05–0.29, p < 0.001) for the primary and secondary analyses, respectively. Relative risk reductions were 94% and 88% in favor of EID for the primary and secondary analyses, respectively. The tertiary analysis included no cases of PML with EID. Conclusion Natalizumab EID is associated with clinically and statistically significantly lower PML risk than SID. Classification of evidence This study provides Class III evidence that for patients with MS, natalizumab EID is associated with a lower PML risk than SID.
Use of an experimental language acquisition paradigm for standardized neuropsychological assessment of learning: A pilot study in young and older adults

ABSTRACT Introduction: Despite the numerous episodic memory tasks used in neuropsychological assessment, relatively few learning tasks are available, with methods lacking the complexity and sophistication to capture very subtle changes in information acquisition. Method: We adapted a previously validated associative learning task for use within an online framework, utilizing real-world stimuli, in which learning of audio-visual pairs of Chinese characters and English words occurs over 5 days. The aim of this study was to validate our adaptation to the task, provide estimates of rates of learning in both young and older adults, as well as provide a methodological framework for further adaptation and development of the paradigm. A total of 30 young adults and 30 older adults completed 5 days of the Chinese Characters Learning Task (CCLT). Results: Results indicated that rates of learning on the adapted task were comparable to the original paradigm and consistent across variations to testing frequency and duration. Our results also indicate the presence of a significant age-related impairment in the rate and accuracy of learning, with young adults aged 18–45 years performing significantly better than older adults aged 65–85 years, that was not due to differences in reaction time. Conclusions: These findings suggest that daily measurement of cognition via an online platform can detect age-related impairments in learning and is therefore applicable for use within the context of age-related disorders of memory and learning.
Does Dog Ownership Affect Physical Activity, Sleep, and Self-Reported Health in Older Adults?

Physical activity (PA) is crucial for maintaining good health of older adults and owning a dog and walking it can enforce it. The purpose of this study was to evaluate the effect of dog ownership on PA in older adults as well as its positive impact on perceived degree of health, and sleep. There were 44 participants of mean age 68 ± 5.4 years (18 males, 26 females) enrolled in this study (dog owners—DO, n = 26; non-dog owners—NDO, n = 18). Xiaomi Mi Band 2 accelerometer, International Physical Activity Questionnaire- Short form (IPAQ-Short Form) and SF-36 questionnaires were used to measure the level of PA, sleep, and subjective health. A statistically significant difference was observed in favor of dog owners in most of the monitored parameters. All accelerometer PA parameters (step count, activity time, distance, calories) showed a significant difference at a p < 0.01. Sleep parameters were significant in total sleep length (p = 0.05) and light sleep length (p < 0.05). DO reported higher total PA time (min/week), MET/min/week spent in walking, and spent calories/week (p < 0.05). In SF-36 they reported higher score (p < 0.05) in general health, physical functioning, social functioning, pain, vitality, and emotional well-being. Body mass index (BMI) was significantly lower in the DO group (p < 0.01). The results suggest that dog ownership may affect the overall PA and health of older adults.