Miracle-dz/UniFAR-FTUs huggingface dataset:
ILLNESS REPRESENTATIONS, TREATMENT BELIEFS, MEDICATION ADHERENCE AND HOSPITAL READMISSION IN ELDERLY INDIVIDUALS WITH CHRONIC HEART FAILURE

ii Acknowledgments. iv List of Tables . viii List of Figures . ix CHAPTER 1. THE PROBLEM . 1 Antecedents to Hospital Readmission: Medication Adherence . 6 Illness Representations and Medication Adherence . 7 Treatment Beliefs and Medication Adherence . 8 Medication Adherence as a Mediator . 10 Statement of the Problem . 11 Sub Problems . 11 Definitions.13 Delimitations . 15 Significance of the Study . 16 CHAPTER 2. REVIEW OF THE LITERATURE . 18 Theoretical Framework . 18 The Common-Sense Model of Self-Regulation . 18 Necessity-Concerns Framework . 20 Literature Review.21 Illness Representations and Medication Adherence . 21 Illness Representations and Illness Outcome . 33 Treatment Beliefs and Medication Adherence . 40 Treatment Beliefs and Illness Outcome . 42 Medication Adherence as a Mediator . 44 Hypotheses . 46 CHAPTER 3. METHODS . 51 Research Setting.51 Sampling Methods . 52 Instruments . 53 Brief Illness Perception Questionnaire . 53 Beliefs about Medicines Questionnaire . 57 Medication Adherence Report Scale . 60 vii Hospital Readmission . 61 Demographic Questionnaire . 62 Procedure for Data Collection . 62 Data Analysis . 64 Human Subjects Protection . 66 CHAPTER 4. DATA ANALYSIS . 68 Demographics of Study Sample.68 Description of the Study Variables . 70 Results of Hypothesis Testing . 73 Hypotheses 1–4 . 74 Hypothesis 5.75 Hypotheses 6–9 . 76 Hypothesis 10.76 Hypotheses 11–15 . 77 Ancillary Findings . 77 Tests of Moderation . 81 CHAPTER 5. DISCUSSION OF THE FINDINGS . 87 Illness Representations and Medication Adherence . 87 Necessity-Concerns Differential and Medication Adherence . 93 Illness Representations and 30-Day Hospital Readmission . 94 Necessity-Concerns Differential and 30-Day Hospital Readmission . 99 Adequacy of the CSM for Explaining Medication Adherence and Hospital Readmission in Older Adults with CHF . 100 CHAPTER 6. SUMMARY, CONCLUSIONS, IMPLICATIONS, AND RECOMMENDATIONS . 101 Summary . 101 Limitations . 104 Conclusions and Implications for Nursing . 105 Recommendations . 107 REFERENCES . 109 CURRICULUM VITAE . 133
Studies on the phytomodulatory potential of fenugreek (Trigonella foenum‐graecum) on bisphenol‐A induced testicular damage in mice

Bisphenol A (BPA), an organic synthetic compound and endocrine disruptor, which majorly cause deleterious effects on male reproductory system. Fenugreek (Trigonella foenum‐graecum), associated with Leguminosae family is used as a herbal medicine with potent antioxidant properties. The present study was aimed to scrutinise the preventative role of fenugreek seeds aqueous extract (FSEt) on BPA‐induced testicular damage in mice. Study included four different groups of male Balb/c mice: contol (C), fenugreek (FSEt), bisphenol A (BPA) and fenugreek + bisphenol A (FSEt + BPA). After two months of treatment, assessment of sperm parameters, antioxidant defence system, histopathological studies, germ cell count and gene expression of intrinsic apoptotic pathway were carried out. Administration of FSEt improved the damage caused by BPA as indicated by improved sperm parameters. FSEt‐administered mice showed improvement in the histoarchitecture compared with BPA‐administered animals. In addition, fenugreek treatment showed reduced levels of malondialdehyde and elevated levels of antioxidant enzymes. Expression studies of apoptotic markers revealed a significant decrease in the expression of Bcl‐2 and significant increase in caspase‐9 and caspase‐3. However, FSEt restored the deleterious effects caused by BPA. The current findings plausibly might have promising protective role against BPA‐induced testicular damage.
LASP1 promotes proliferation, metastasis, invasion in head and neck squamous cell carcinoma and through direct interaction with HSPA1A

LIM and SH3 protein 1 (LASP1) is a specific focal adhesion protein that promotes metastasis in a variety of tumours. However, its role in head and neck squamous cell carcinoma (HNSCC) has not been fully validated. The purpose of this study was to analyse the interaction of LASP1 and its binding partner in HNSCC. The expression of LASP1 and HSPA1A in HNSCC was analysed by real‐time PCR and Western blot. The effects of LASP1 on the biology behaviour of HNSCC cell lines were observed in vivo and in vitro. Co‐immunoprecipitation analysis was performed to confirm the interaction between LASP1 and HSPA1A. LASP1 was highly expressed in HNSCC and associated with poor prognosis for patients. LASP1 also promoted cell proliferation, colony formation, invasion and cell cycle G2/M phase transition. Heat shock protein family A member 1A (HSPA1A) is identified as a chaperone protein of LASP1 and co‐localized in the cytoplasm. HSPA1A positively regulates the interaction of LASP1 with P‐AKT and enhances the malignant behaviour of HNSCC cells. LASP1 and HSPA1A are both up‐regulated in HNSCC, and directly binds to each other. Double inhibition of LASP1 and HSPA1A expression may be an effective method for the treatment of HNSCC.
Chemotaxis and cyclic‐di‐GMP signalling control surface attachment of Escherichia coli

Attachment to surfaces is an important early step during bacterial infection and during formation of submerged biofilms. Although flagella‐mediated motility is known to be important for attachment of Escherichia coli and other bacteria, implications of motility regulation by cellular signalling remain to be understood. Here, we show that motility largely promotes attachment of E. coli, including that mediated by type 1 fimbriae, by allowing cells to reach, get hydrodynamically trapped at and explore the surface. Inactivation or inhibition of the chemotaxis signalling pathway improves attachment by suppressing cell reorientations and thereby increasing surface residence times. The attachment is further enhanced by deletion of genes encoding the cyclic diguanosine monophosphate (c‐di‐GMP)‐dependent flagellar brake YcgR or the diguanylate cyclase DgcE. Such increased attachment in absence of c‐di‐GMP signalling is in contrast to its commonly accepted function as a positive regulator of the sessile state. It is apparently due to the increased swimming speed of E. coli in absence of YcgR‐mediated motor control, which strengthens adhesion mediated by the type 1 fimbriae. Thus, both signalling networks that regulate motility of E. coli also control its engagement with both biotic and abiotic surfaces, which has likely implications for infection and biofilm formation.
Key Frame Extraction Algorithm for Surveillance Video Based on Golden Section

The traditional key frame extraction algorithm can't effectively segment the surveillance video, and it can't focus on the moving objects in the surveillance video data. In this paper, a key frame extraction algorithm based on golden section is proposed. The method first detects and tracks the moving target in the surveillance video, and calculates the entropy value of the foreground image. Secondly, the golden section in mathematical calculation is introduced to divide the sub-segment of the surveillance video, and the standard deviation of the foreground image entropy is used to measure the intra-frame similarity of the video sub-segments. If the intra-frame similarity is low, the frame at the golden section point is selected as the video key frame;if the difference within the video segment is large, golden section is continued until there is no significant difference in the video frames in all video sub-segments. in all the video sub-segments. Through experimental tests on a variety of surveillance video data and comparison with traditional algorithms, the experimental results show that the proposed algorithm effectively compresses the original surveillance video, and can extract the moving objects in the surveillance video more completely.
Tauroursodeoxycholic acid acts via TGR5 receptor to facilitate DNA damage repair and improve early porcine embryo development

DNA damage associated with assisted reproductive technologies is an important factor affecting gamete fertility and embryo development. Activation of the TGR5 receptor by tauroursodeoxycholic acid (TUDCA) has been shown to reduce endoplasmic reticulum (ER) stress in embryos; however, its effect on genome damage responses (GDR) activation to facilitate DNA damage repair has not been examined. This study aimed to investigate the effect of TUDCA on DNA damage repair and embryo development. In a porcine model of ultraviolet light (UV)‐induced nuclear stress, TUDCA reduced DNA damage and ER stress in developing embryos, as measured by γH2AX and glucose‐regulated protein 78 immunofluorescence, respectively. TUDCA was equally able to rescue early embryo development. No difference in total cell number, DNA damage, or percentage of apoptotic cells, measured by cleaved caspase 3 immunofluorescence, was noted in embryos that reached the blastocyst stage. Interestingly, Dicer‐substrate short interfering RNA‐mediated disruption of TGR5 signaling abrogated the beneficial effects of TUDCA on UV‐treated embryos. Quantitative PCR analysis revealed activation of the GDR, through increased messenger RNA abundance of DNAPK, 53BP1, and DNA ligase IV, as well as the ER stress response, through increased spliced XBP1 and X‐linked inhibitor of apoptosis. Results from this study demonstrated that TUDCA activates TGR5‐mediated signaling to reduce DNA damage and improve embryo development after UV exposure.
Application of low-concentration contrast agents and low-tube-voltage computed tomography to chest enhancement examinations: A multicenter prospective study

To evaluate the influence of low-concentration contrast agents and low-tube-voltage computed tomography on chest enhancement examinations, we conducted a multicenter prospective study. A total of 216 inpatients enrolled from 12 different hospitals were randomly divided into four groups: A: voltage, 120 kVp; iohexol, 350 mgI/mL; B: voltage, 100 kVp, iohexol, 350 mgI/mL; C: voltage, 120 kVp, iodixanol, 270 mgI/mL; and D: voltage, 100 kVp, iodixanol, 270 mgI/mL. Subjective image quality was assessed by two radiologists and compared by weighted kappa test. The objective image scores, scanning radiation doses, and pathological coincidence rates were analyzed. There were no significant differences in gender, age, height, weight, and body mass index between the four groups (p > 0.05). The consistency of the radiologists’ ratings were good, with kappa value ranging from 0.736 (95% confidence interval: 0.54–0.933) to 0.809 (95% confidence interval: 0.65–0.968), and there was no difference in subjective image score between the four groups. The computed tomography value of group D had no difference with group A. The volume computed tomography dose index, dose length product, and effective dose of group D (6.93 ± 3.03, 241.55 ± 104.75, and 3.38 ± 1.47, respectively) were all significantly lower than those of group A (10.30 ± 4.37, 359.70 ± 152.65, and 5.04 ± 2.14, respectively). There was no significant difference in the imaging diagnosis accuracy rate between the four groups (p > 0.05). The results indicated that low-concentration contrast agents (270 mgI/mL) and low-tube-voltage (100 kVp) computed tomography can not only decrease radiation dose but also guarantee the image quality and meet the needs of imaging diagnosis in chest enhancement examinations, which make it possible for its generalization and application.
Engagement barriers and service inequities in the NHS Breast Screening Programme: Views from British-Pakistani women

Objectives Previous research has largely attempted to explore breast screening experiences of South Asian women by combining opinions from Pakistani, Bangladeshi, and Indian women. This research often fails to reach the most underserved sub-groups of this population, with socioeconomic status not routinely reported, and English fluency being a participation requirement. With uptake low amongst British-Pakistani women, this study explores the experiences these women encounter when accessing the NHS Breast Screening Programme. Methods 19 one-to-one semi-structured interviews were carried out with British-Pakistani women from East Lancashire, UK. 14 interviews were conducted via an interpreter. Results Data were analysed using thematic analysis. Three themes were identified: ‘Absence of autonomy in screening and healthcare access’ describes how currently the screening service does not facilitate confidentiality or independence. Access requires third-party intervention, with language barriers preventing self-expression. ‘Appraisal of information sources’ makes distinctions between community and NHS communication. Whereas community communication was invaluable, NHS materials were deemed inaccessible due to translation incongruences and incomprehensible terminology. ‘Personal suppositions of breast screening’ explores the subjective issues associated with disengagement, including, the cultural misalignment of the service, and perceiving screening as a symptomatic service. Conclusions British-Pakistani women face some unique challenges when accessing breast screening. To promote uptake, the service needs to address the translation of screening materials and optimize upon community networks to disseminate knowledge, including knowledge of the screening environment within the context of culture to promote informed choice about attendance.
A New End-to-End Long-Time Speech Synthesis System Based on Tacotron2

End-to-end speech synthesis breaks away from the original system framework and directly converts text into speech. Although it is shown that Tacotron2 is superior to traditional piping systems in terms of speech naturalness, it still has many defects. A flaw in tacotron2 is mentioned in this paper. , which impacts negatively upon the synthesis quality and the synthesized length of speech. It is cumulative error between training process (forward) and synthesis process (inference). In order to improve this problem, an unsupervised GAN (Generative Adversarial Network) model was proposed based on the Tacotron2. The proposed GAN model can also optimize the prosody of synthesize speech because of the prosody discriminator is also designed in our model. For further reduce the cumulative error mentioned above, this paper propose a training strategy called "random down" based on Tacotron2. And then demonstrate that the unimportant attention weights could be a contributing factor to cumulative error when the input sequence is too long. For this, a window has been added to the attention weights. Through these method, the length of the speech synthesis is improved to about 1000 encoder output. The prosody of synthetic speech has also been improved.
Twins! Microsatellite analysis of two embryos within one egg case in oviparous elasmobranchs

Elasmobranchs display various reproductive modes, which have been key to their evolutionary success. In recent decades there has been a rise in the number of reported cases of foetal abnormalities including fertilised, double-embryos held within one egg capsule, hereafter referred to as twins. Previously, the occurrences of twin egg cases have been reported in two batoid and one shark species. We report the first cases of twins in three species of oviparous elasmobranchs: the undulate ray (Raja undulata), the nursehound (Scyliorhinus stellaris), and the small-spotted catshark (Scyliorhinus canicula). We investigated the genetic relationships between the twins in S. stellaris, and S. canicula using microsatellite markers. Whilst the S. stellaris twins displayed the same genotypes, we found that the S. canicula twin individuals arose through heteropaternal superfecundation. This is the first reported incidence of such a paternity in elasmobranchs. The relationship between environmental change and reproductive strategy in elasmobranchs is unclear and further research is needed to determine its effect on the prevalence and mechanisms of formation of elasmobranch twins.
Long‐term NaHS administration reduces oxidative stress and apoptosis in a rat model of left‐side varicocele

The main aim of this study was to assay the testicular H2S levels in the varicocele rat model and then to investigate the protective effects of NaHS on morphometric changes, sperm parameters, oxidative stress and apoptosis markers in rat's testis. D,L‐propargylglycine (PAG) was administrated to show the effects of cystathionine γ‐lyase enzyme (CSE) inhibition in the varicocele. Rats were assigned to four groups: (a) Sham, (b) varicocele, (c) varicocele + PAG and (d) varicocele + NaHS. Animals in varicocele + NaHS group received 30 µmol/L NaHS in drinking water for 56 days. In the varicocele + PAG group, animals received PAG 19 mg/kg twice a week. Morphometric assessment, oxidative stress markers, testicular H2S levels, sperm parameters, TUNEL assay and expression of Bax/Bcl2 were evaluated at the end of experiment. Testicular H2S levels were significantly decreased in varicocele group. NaHS significantly improved sperm parameters, morphometric characteristics and oxidative stress compared to varicocele group. Oxidative stress status deteriorated in the PAG group compared to the varicocele group. This study showed that a low testicular H2S level might play a critical role in male infertility. Thus, NaHS administration may be a promising treatment strategy for male infertility in varicocele. In addition, CSE may not be the only important enzyme in testicular H2S production.
The subjective value of a smile alters social behaviour

Face-to-face social behaviour is difficult to explain, leading some researchers to call it the “dark matter” of psychology/neuroscience [1]. We apply an idea from neuroeconomics to this problem, suggesting that how people subjectively value facial expressions should predict usage differences during unconstrained interaction. Specifically, we ask whether the subjective value of smiles is malleable as a consequence of immediate social experience and how this relates to smiling during face-to-face interactions. We measured the value of a smile in monetary terms and found that increases in people’s social neediness caused devaluation of polite smiles but no changes in how they valued genuine smiles. This result predicts that participants induced to feel high levels of social need should be less responsive to their social partners’ polite smiles in a subsequent unconstrained social interaction. As expected, high social-need participants returned fewer polite smiles when interacting with a partner, leading to poor interaction outcomes. Genuine smile reciprocity remained unchanged. Findings show that social states influence real-world interactions by changing social-cue valuation, highlighting a potential mechanism for understanding the moment-to-moment control of social behaviour and how behaviour changes based on people’s subjective evaluations of the social environment.
The IFITM protein family in adaptive immunity

Interferon‐inducible transmembrane (IFITM) proteins are a family of small homologous proteins, localized in the plasma and endolysosomal membranes, which confer cellular resistance to many viruses. In addition, several distinct functions have been associated with different IFITM family members, including germ cell specification (IFITM1–IFITM3), osteoblast function and bone mineralization (IFITM5) and immune functions (IFITM1–3, IFITM6). IFITM1–3 are expressed by T cells and recent experiments have shown that the IFITM proteins are directly involved in adaptive immunity and that they regulate CD4+ T helper cell differentiation in a T‐cell‐intrinsic manner. Here we review the role of the IFITM proteins in T‐cell differentiation and function.
Psychometric properties of the parent’s versions of the SDQ and the PANAS-X in a community sample of Portuguese parents

This study examined the psychometric properties of the parent’s versions of the Strengths and Difficulties Questionnaire (SDQ) and the Positive and Negative Affect Schedule–Extended Form (PANAS-X) in a community sample of Portuguese parents. A total of 1100 SDQ and PANAS-X were collected from an online sample of 761 parents, whose ages ranged from 23 to 65 years (M = 42, SD = 5). Confirmatory factor analyses provided evidence of the internal factor structure of both the SDQ and the PANAS-X and invariance of the factor structure across age and gender groups, with the exception of the SDQ, which failed to provide evidence of invariance between genders. Internal reliability and discriminant validity were confirmed for both measures, although convergent validity was only confirmed for the PANAS-X. Concurrent validity was also confirmed by comparing the results from the SDQ dimensions and the PANAS-X broad dimensions subscales.
Psychostimulant Use for Neuroenhancement (Smart Drugs) among College Students in Brazil

Abstract Background: College students are susceptible to using cognitive enhancement drugs, also known as smart drugs. Objectives: estimate the prevalence of smart drug use and investigate the factors related to access and use among undergraduate students. Methods: cross-sectional study performed among all students who entered the university in 2017 using an anonymous, self-administered questionnaire. Smart drug usage was defined as taking methylphenidate, modafinil or piracetam at any point in life and in the preceding 12 months. We characterized the means of obtaining smart drugs, reasons for using and students’ residential situation. We asked students who did not use any medication if they were interested in taking it and the reasons for not using. Results: Out of 1865 respondents, 4.2% had used smart drugs in the last 12 months, and the prevalence among law students reached 14.3%. The most commonly used smart drug was methylphenidate. Among the students who did not present ADD diagnosis, the drug was obtained mostly through a friend. More than 300 students reported a desire to use some smart drug, but they did not, mainly due to the fear of side effects. Conclusions: The current study has found a variety of frequency of smart drug use among college students and has also showed that many students are willing to take some kind of cognitive enhancement drug. Therefore, it is important to discuss this issue from a public health perspective.
ADAP1 promotes invasive squamous cell carcinoma progression and predicts patient survival

ADAP1, a GTPase-activating protein (GAP) for the small GTPase ARF6, is a strong predictor of poor survival in early-stage squamous cell carcinoma patients and a critical mediator of TGF-β-induced invasive cell migration by facilitating basement membrane breakdown. Invasive squamous cell carcinoma (SCC) is aggressive cancer with a high risk of recurrence and metastasis, but the critical determinants of its progression remain elusive. Here, we identify ADAP1, a GTPase-activating protein (GAP) for ARF6 up-regulated in TGF-β-responding invasive tumor cells, as a strong predictor of poor survival in early-stage SCC patients. Using a mouse model of SCC, we show that ADAP1 overexpression promotes invasive tumor progression by facilitating cell migration and breakdown of the basement membrane. We found that ADAP1-rich, TGF-β-responding tumor cells exhibit cytoplasmic laminin localization, which correlated with the absence of laminin and type IV collagen from the pericellular basement membrane. Interestingly, although tumors overexpressing a GAP activity-deficient mutant of ADAP1 resulted in morphologically complex tumors, those tumor cells failed to breach the basement membrane. Moreover, Adap1 deletion in tumor cells ameliorated the basement membrane breakdown and had less invading cells in the stroma. Our study demonstrates that ADAP1 is a critical mediator of TGF-β-induced cancer invasion and might be exploited for the treatment of high-risk SCC.