Miracle-dz/UniFAR-FTUs huggingface dataset:
Hemodynamic differences by increasing low profile visualized intraluminal support (LVIS) stent local compaction across intracranial aneurysm orifice

Background The Low-profile Visualized Intraluminal Support device (LVIS) has been successfully used to treat cerebral aneurysm, and the push-pull technique has been used clinically to compact the stent across aneurysm orifice. Our aim was to exhibit the hemodynamic effect of the compacted LVIS stent. Methods Two patient-specific aneurysm models were constructed from three-dimensional angiographic images. The uniform LVIS stent, compacted LVIS and Pipeline Embolization Device (PED) with or without coil embolization were virtually deployed into aneurysm models to perform hemodynamic analysis. Intra-aneurysmal flow parameters were calculated to assess hemodynamic differences among different models. Results The compacted LVIS had the highest metal coverage across the aneurysm orifice (case 1, 46.37%; case 2, 67.01%). However, the PED achieved the highest pore density (case 1, 19.56 pores/mm2; case 2, 18.07 pores/mm2). The compacted LVIS produced a much higher intra-aneurysmal flow reduction than the uniform LVIS. The PED showed a higher intra-aneurysmal flow reduction than the compacted LVIS in case 1, but the results were comparable in case 2. After stent placement, the intra-aneurysmal flow was further reduced as subsequent coil embolization. The compacted LVIS stent with coils produced a similar reduction in intra-aneurysmal flow to that of the PED. Conclusions The combined characteristics of stent metal coverage and pore density should be considered when assessing the flow diversion effects of stents. More intra-aneurysmal flow reductions could be introduced by compacted LVIS stent than the uniform one. Compared with PED, compacted LVIS stent may exhibit a flow-diverting effect comparable to that of the PED.
Inhibition of PI3K/Akt signaling suppresses epithelial-to-mesenchymal transition in hepatocellular carcinoma through the Snail/GSK-3/beta-catenin pathway

Background/Aims Patients with advanced hepatocellular carcinoma (HCC) have a poor prognosis due to the lack of effective systemic therapies. Epithelial-to-mesenchymal transition (EMT) is a pivotal event in tumor progression, during which cancer cells acquire invasive properties. In this study, we investigated the effects of phosphatidylinositol 3-kinase (PI3K) inhibitors, including LY294002 and idelalisib, on the EMT features of HCC cells in vitro. Methods Human HCC cell lines, including Huh-BAT and HepG2, were used in this study. Cell proliferation was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide, and cell cycle distributions were evaluated using a flow cytometer by propidium iodide staining. Immunofluorescence staining, quantitative real-time polymerase chain reaction, and immunoblotting were performed to detect EMT-associated changes. Results PI3K inhibitors suppressed the proliferation and invasion of HCC cells and deregulated the expression of EMT markers, as indicated by increased expression of E-cadherin, an epithelial marker, and decreased expression of N-cadherin, a mesenchymal marker, and Snail, a transcription factor implicated in EMT regulation. Furthermore, LY294002 and idelalisib inhibited the phosphorylation of GSK-3β and induced the nuclear translocation of GSK-3β, which corresponded to the downregulation of Snail and β-catenin expressions in Huh-BAT and HepG2 cells. Conclusions The inhibition of PI3K/Akt signaling decreases Snail expression by enhancing the nuclear translocation of GSK-3β, which suppresses EMT in HCC cells, suggesting the potential clinical application of PI3K inhibitors for HCC treatment.
Comparing Trace Element Bioaccumulation and Depuration in Snails and Mayfly Nymphs at a Coal Ash–Contaminated Site

We examined the bioaccumulation of essential (Cu, Fe, Se, and Zn) and nonessential (As and Hg) trace elements in 2 aquatic invertebrate species (adult snails and mayfly nymphs) with different feeding habits at the site of a coal ash spill. Differences in food web pathway, exposure concentrations, and biological processing affected bioaccumulation patterns in these species. Mayflies had higher body burdens, but snails had higher retention of most elements studied. Environ Toxicol Chem 2020;39:2437–2449. © 2020 SETAC
Retrieval of total and tropospheric ozone from observations by the Global Ozone Monitoring Experiment

A Fast Delivery (FD) system has been developed to provide GOME total ozone columns within 3 hours after observation. This meets the growing demand for near-real time ozone products for applications as the assimilation of ozone in Numerical Weather Prediction (NWP) models, monitoring the status of the ozone layer and improving surface UV radiation forecasts. The FD system uses only a small part of the raw GOME data that are available in near-real time. The FD level 0-to-1 and level 1-to-2 processors are based on algorithms as used within the off-line ESA/DLR GOME Data Processor (GDP). However, several changes in the algorithms have been made to improve the retrieval of the ozone columns: (1) the use of effective ozone absorption cross-sections based on ECMWF temperature forecast in the ozone slant column fit, (2) the use of the DAK radiative transfer model and the Fortuin and Kelder ozone climatology for the air mass factor calculations and (3) the use of the FRESCO cloud algorithm. The accuracy of the FD ozone columns has been determined by a pseudo-global validation study involving ground-based total ozone observations from about 15 NDSC sites. There is a reasonable general agreement with the ground-based measurements (within 5% for lowand mid-latitudes, within –10 to +5% for high latitudes) and the level of quality meets the requirements for near-real time applications. This chapter has been published as: P. J. M. Valks, A. J. M. Piters, J. C. Lambert, C. Zehner and H. Kelder, Int. J. Remote Sensing, Vol. 24, 423-436, 2003.
Geovolume Visualization And Interpretation: Speed And Accuracy With Auto-tracking

Geovolume visualization allows the geoscientist to examine many different interpretation possibilities for every data set. However, to gain both speed and accuracy, interpreters must begin to utilize faster methods of (seismic, reservoir characterization etc.) interpretations. Old methods of grid digitizing and interpolation are too slow and inaccurate. New methods began in the 1980’s with trace-based autotracking, and in the 1990’s voxel-based tracking gained momentum. The attribute-based methods of the 2000’s involve the combination of multi-attributes and multi-samples with three-dimensional voxel tracking. This paper will compare and give examples of these tracking techniques along with recommendations of when to use them.
ANALYSIS OF THE INFLUENCE OF NON-CONSERVED AMINO ACID RESIDUES BY SITE-DIRECTED MUTAGENESIS OF PHOTOSYSTEM I FROM CHLAMYDOMONAS REINHARDTII*

We applied optical spectroscopy, magnetic resonance techniques, and redox titrations to investigate the properties of the primary electron donor P700 in photosystem I (PS I) core complexes from cyanobacteria (Thermosynechococcus elongatus, Spirulina platensis, and Synechocystis sp. PCC 6803), algae (Chlamydomonas reinhardtii CC2696), and higher plants (Spinacia oleracea). Remarkable species-specific differences of the optical properties of P700 were revealed monitoring the ( 3 P700 –P700) and (P700–P700) absorbance and CD difference spectra. The main bleaching band in the Qy region differs in peak position and line width for the various species. In cyanobacteria the absorbance of P700 extends more to the red compared with algae and higher plants which is favorable for energy transfer from red core antenna chlorophylls to P700 in cyanobacteria. The amino acids in the environment of P700 are highly conserved with two distinct deviations. In C. reinhardtii a Tyr is found at position PsaB659 instead of a Trp present in all other organisms, whereas in Synechocystis a Phe is found instead of a Trp at the homologous position PsaA679. We constructed several mutants in C. reinhardtii CC2696. Strikingly, no PS I could be detected in the mutant YW B659 indicating steric constraints unique to this organism. In the mutants WA A679 and YA B659 significant changes of the spectral features in the ( 3 P700 –P700), the (P700–P700) absorbance difference and in the (P700–P700) CD difference spectra are induced. The results indicate structural differences among PS I from higher plants, algae, and cyanobacteria and give further insight into specific protein-cofactor interactions contributing to the optical spectra.
Dionysia robusta (Primulaceae), a new species from W Iran

Abstract: A new species from the W part of the Iranian Zagros Mountains in Ilam province, Dionysia robusta (Primulaceae), is described, illustrated and compared with similar and related species. It differs from these relatives in leaf shape, length and density of glandular hairs, and shape of the calyx. The DNA sequence of the nuclear ribosomal ITS region of D. robusta is most similar to that of D. gaubae. Citation: Younesi S. , Mehregan I. , Assadi M. , Nejadsattari T. & Lidén M. 2016: Dionysia robusta (Primulaceae), a new species from W Iran. — Willdenowia 46: 105–112. doi: http://dx.doi. org/10.3372/wi.46. 46108 Version of record first published online on 1 April 2016 ahead of inclusion in April 2016 issue.
Discrete Choice Methods with Simulation: Numerical Maximization

This book describes the new generation of discrete choice methods, focusing on the many advances that are made possible by simulation. Researchers use these statistical methods to examine the choices that consumers, households, firms, and other agents make. Each of the major models is covered: logit, generalized extreme value, or GEV (including nested and cross-nested logits), probit, and mixed logit, plus a variety of specifications that build on these basics. Recent advances in Bayesian procedures are explored, including the use of the Metropolis-Hastings algorithm and its variant Gibbs sampling. This second edition adds chapters on endogeneity and expectation-maximization (EM) algorithms. No other book incorporates all these fields, which have arisen in the past 25 years. The procedures are applicable in many fields, including energy, transportation, environmental studies, health, labor, and marketing.
Taakgroepen: duurzaam verbeteren? : tien jaar praktijkervaring met sociotechnisch organiseren

• A submitted manuscript is the author's version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers.
Investigating attitudes towards caring for people with HIV/AIDS among hospital care workers in Ibadan, Nigeria: the role of self-efficacy.

Fear of HIV infection and its consequences may affect the willingness and capacity of health care workers to provide good quality care for people with HIV/AIDS (PWHAs). The study was founded on the proposition that self-efficacy may mediate the attitudinal disposition of health care workers related to provision of care to PWHAs. Two hundred and ten physicians (n = 103) and nurses (n = 107) sampled from the University College Hospital, Ibadan, Nigeria, responded (48% response rate) to a questionnaire which addressed self-efficacy relating to HIV/AIDS, knowledge about HIV/AIDS and treatment of and attitudes towards HIV/AIDS patients. Attitude questions included items on fear of HIV infection, futility in providing care for HIV patients, distress in caring for the patient who is likely to die and willingness to care for PWHAs. The major finding was a significant association between reported high selfefficacy and less fear of acquiring HIV, less futility in providing care for PWHAs and increased willingness t.
The Power of the Pill: Oral Contraceptives and Women’s Career and Marriage Decisions

The fraction of U.S. college graduate women entering professional programs increased substantially just after 1970, and the age at first marriage among all U.S. college graduate women began to soar around the same year. We explore the relationship between these two changes and the diffusion of the birth control pill (“the pill”) among young, unmarried college graduate women. Although the pill was approved in 1960 by the Food and Drug Administration and spread rapidly among married women, it did not diffuse among young, single women until the late 1960s after state law changes reduced the age of majority and extended “mature minor” decisions. We present both descriptive time series and formal econometric evidence that exploit cross‐state and cross‐cohort variation in pill availability to young, unmarried women, establishing the “power of the pill” in lowering the costs of long‐duration professional education for women and raising the age at first marriage.
Spacing Patterns in Alligator Nests

The pattern of alligator nest location is measured for four consecutive years across a set of quadrats on Orange Lake (Alachua County) Florida. The nests are clumped, and this clumping is evident even given controls for habitat heterogeneity. The recent recovery of Alligator mis- sissippiensis from endangered status has generated a significant renaissance of research into this reptile's biology. It is particularly important for biologists and management specialists alike to learn what factors might limit the density of alligator populations. For over 20 years workers in Louisiana have known that
Seasonal and spatial variation of the Montagu’s Harrier’s Circus pygargus diet in Eastern Poland

Capsule: The diet of the Montagu’s Harrier Circus pygargus is variable and comprises the most available prey at a given time of the season. We found no evidence for a relationship between diet and land-use in the core foraging zone. Aims: We investigated whether the diet of the Montagu’s Harrier reflects the available prey and how it changes across the breeding season and in relation to land-use. Methods: We analysed pellets collected at nests between 2007 and 2011. We looked for nonlinear patterns in the occurrence of prey categories in the pellets as a nonlinear function of the Julian date. Moreover, we tested whether the diet is affected by land-use within a radius of 2299 m from the nest. Results: Four thousand four hundred and sixty-five prey items were found in 880 pellets and 76 prey remains collected at 63 sites. The diet did not depend on the land-use structure but showed a significant temporal variation. Conclusions: The diet of the Montagu’s Harrier follows the availability of the prey in the foraging habitat. We conclude that the type of land-use in the vicinity of the nesting habitat has a rather weak effect on the diet of the Montagu’s Harrier.
Effects of Arsenic on DNA Synthesis and E2F1 Expression in Human Epidermal Keratinocyte

Objective To study the effects of low concentration of arsenic on cell proliferation and expression of E2F1 in keratinocyte. Methods Human epidermal keratinocyte (cell line HaCaT) was cultured in vitro.3H-TdR method was used to detect DNA synthesis of keratinocyte treated with various concentration of arsenic. The expression of E2F1 in keratinocyte was assessed by RT-PCR method. Results Ranging from 0.5nmol/L to 16nmol/L,arsenic trioxide produced a modest increase of keratinocyte DNA synthesis. The amount of incorporated 3H-TdR decreased and returned to baseline levels at concentrations more than 16nmol/L. RT-PCR analysis showed that levels of E2F1 mRNA was elevated in HaCaT cells with increased DNA synthesis compared with that of untreated cells. Conclusion Certain concentration arsenic led to enhanced DNA synthesis and increased expression of E2F1, which may be a part of the pathological mechanism of skin disease related to arsenic.
Moving from Quality Attribute Requirements to Architectural Decisions.

Quality attribute models are proposed as the linkage between a specification of a quality attribute requirement and a design fragment that is focused on achieving that requirement. Each quality attribute model has a collection of parameters that must be specified in order to determine from the model whether a requirement will be met. These parameters can be bound through design decisions, through values given from a quality requirement, or through knowledge of the designer. Architectural tactics are designed to relate design decisions to control of a quality attribute model parameter in order to achieve particular responses. In this paper, we present a series of steps that enable moving from a single quality attribute requirement to a design fragment focused on achieving that requirement. We demonstrate these steps through application to an embedded system.
Homology Modeling of Versatile Peroxidases from Pleurotus sapidus Reveals Residues for Site Directed Mutagenesis to Enhance theBioremediation Ability

Homology Modeling of Versatile Peroxidases from Pleurotus sapidus Reveals Residues for Site Directed Mutagenesis to Enhance the Bioremediation Ability Ligninolytic enzymes have potential applications in many fields and they are involved in the degradation of various xenobiotic compounds and dyes. Versatile peroxidases, a fungal enzyme, are industrially attractive and their applications have expanded to the field of bioremediation. Designing an enzyme that have higher catalytic activity, stability and fitting well with the required conditions are one of the challenges of today’s biotechnology. Versatile peroxidases are known to efficiently oxidize non-natural substrates like polycyclic aromatic hydrocarbons (PAHs). The accessibility of the PAHs to microbial cells is less. Hence by increasing the hydrophobicity of versatile peroxidases, the chance of the enzyme to meet the hydrophobic substrates such as PAHs in a contamination site can be increased. We have used an insilico approaches for optimal designing of versatile peroxidase to enhance its bioremediation ability.
CRYSTALLOGRAPHY AT (SUB) ATOMIC RESOLUTION AND QUANTUM CHEMISTRY REVEALING DETAILS OF CATALYSIS

A series of crystal structures of trypsin, containing either an autoproteolytic cleaved peptide fragment or a covalently bound inhibitor, were determined at atomic and ultra-high resolution and subjected to ab initio quantum chemical calculations and multipole refinement. Quantum chemical calculations reproduced the observed active site crystal structure with severe deviations from standard stereochemistry and indicated the protonation state of the catalytic residues. Multipole refinement directly revealed the charge distribution in the active site and proved the validity of the ab initio calculations. The combined results confirmed the catalytic function of the active site residues and the two water molecules acting as the nucleophile and the proton donor. The crystal structures represent snapshots from the reaction pathway, close to a tetrahedral intermediate. The de-acylation of trypsin then occurs in true SN2 fashion.
A new species of Brazilian Dendrocephalus (Anostraca, Thamnocephalidae)

Dendrocephalus thieryi nov. sp. , discovered in the state of Minas Gerais, Brazil, is described. The new species is defined by a unique morphology of its male frontal appendage and of the endopodites of the first four thoracopods. A dichotomous key to all known Dendrocephalus species based on male morphology is presented.
Quasi-Cyclic Low Density Parity Check Codes

In this work, the construction of low density parity check codes (LDPCs) from circulant permutation matrices is investigated. It is shown that such codes can not have a Tanner graph representa- tion with girth larger than 12, and a relatively loose necessary and sufficient condition for the code to have a girth of 6, 8, 10 or 12 is derived. These results suggest that families of LDPC codes with such girth values are relatively easy to obtain and consequently, additional parameters such as the minimum distance or the number of redundant check sums should be considered. I. INTRODUCTION Recently, several methods for constructing good families of LDPC codes have been proposed. These methods can be de- composed into two main classes: random or pseudo-random constructions, and algebraic constructions. Algebraic con- structions can themselves be decomposed into two main cate- gories. The first category is based on finite geometries, while the second category is based on circulant permutation matri- ces. In fact these two methods are interrelated.
Effect of energy sources on the milk production and reproduction of lactating Holstein cows

ABSTRACT The objective of the study was to evaluate the effect of energy sources on milk production and reproduction of dairy cows on a pasture-based feeding system. Following parturition, 201 Holstein cows from the Elsenburg herd were fed ad libitum cultivated irrigated kikuyu-ryegrass pastures for 22 weeks. Cows were divided into three groups according to concentrate supplementation, of which the energy was provided by starch and/or fat. These were grouped according to parity, body live weight and milk yield of previous lactation. The control consisted of low levels of standard supplement while treatments consisted of supplements of high starch-low fat (HSLF) and high starch-low fat low starch-high fat (HSLF-LSHF) given to cows on pastures. Treatment P-HSLF was a glucogenic regime made of maize. Treatment P-HSLF-LSHF was a high starch/high fat combination treatment, whereby a glucogenic diet was offered for the first 60 days of lactation as per treatment P-HSLF and followed from 61 to 154 days by a lipogenic (low starch-high fat) diet made of wheat bran and calcium salts of palm fatty acids. Cows were milked twice a day and concentrate supplementations were fed after each milking. Milk yields and body live weight of dairy cows were affected (P < 0.05) by the concentrate levels while milk composition was not affected. The number of services per conception (SPC) and the number of days from calving to first service (CFS) did not differ (P > 0.05) between treatments for both primiparous and multiparous cows. However, the pregnancy rate (PR) of cows at 150 days was affected (P < 0.10) by the feeding programme, with P-HSLF and P-HSLF-LSHF being higher compared to the control. This evidenced that manipulating levels could have influenced the hypothalamic-pituitary-ovarian axis through improved energy balance (EB) and optimize the carry over effects into fertility. Since studies of feeding different energy sources on reproductive performance are still scarce and inconsistent, further investigations with large numbers of animals and emphasis on EB and metabolism are therefore needed to assess the effects of types of energy sources and to understand factors affecting reproduction in dairy cows.