Miracle-dz/UniFAR-FTUs huggingface dataset:
Mitigation of Ionizing Radiation-Induced Gastrointestinal Damage by Insulin-Like Growth Factor-1 in Mice

Purpose: Insulin-like growth factor-1 (IGF-1) stimulates epithelial regeneration but may also induce life-threatening hypoglycemia. In our study, we first assessed its safety. Subsequently, we examined the effect of IGF-1 administered in different dose regimens on gastrointestinal damage induced by high doses of gamma radiation. Material and methods: First, fasting C57BL/6 mice were injected subcutaneously with IGF-1 at a single dose of 0, 0.2, 1, and 2 mg/kg to determine the maximum tolerated dose (MTD). The glycemic effect of MTD (1 mg/kg) was additionally tested in non-fasting animals. Subsequently, a survival experiment was performed. Animals were irradiated (60Co; 14, 14.5, or 15 Gy; shielded head), and IGF-1 was administered subcutaneously at 1 mg/kg 1, 24, and 48 h after irradiation. Simultaneously, mice were irradiated (60Co; 12, 14, or 15 Gy; shielded head), and IGF-1 was administered subcutaneously under the same regimen. Jejunum and lung damage were assessed 84 h after irradiation. Finally, we evaluated the effect of six different IGF-1 dosage regimens administered subcutaneously on gastrointestinal damage and peripheral blood changes in mice 6 days after irradiation (60Co; 12 and 14 Gy; shielded head). The regimens differed in the number of doses (one to five doses) and the onset of administration (starting at 1 [five regimens] or 24 h [one regimen] after irradiation). Results: MTD was established at 1 mg/kg. MTD mitigated lethality induced by 14 Gy and reduced jejunum and lung damage caused by 12 and 14 Gy. However, different dosing regimens showed different efficacy, with three and four doses (administered 1, 24, and 48 h and 1, 24, 48, and 72 h after irradiation, respectively) being the most effective. The three-dose regimens supported intestinal regeneration even if the administration started at 24 h after irradiation, but its potency decreased. Conclusion: IGF-1 seems promising in the mitigation of high-dose irradiation damage. However, the selected dosage regimen affects its efficacy.
Selenium Nanoparticles Improved Intestinal Health Through Modulation of the NLRP3 Signaling Pathway

Selenium nanoparticles (SeNPs) play important roles in promoting animal health, however, their impact on intestinal health remains elusive. This study was intended to evaluate the effects of different doses of SeNPs on the intestinal health, especially the development of goblet cells in the broiler jejunum. A total of 480 1-day-old Arbor Acres broilers were randomly allotted to 5 treatments with 6 replications of 16 chicks each. Birds were fed with low selenium corn-soybean meal-based diets supplemented with 0.1, 0.2, 0.3, or 0.4 mg/kg of SeNPs. On d 21, dietary supplementation of SeNPs effectively reduced the mortality of broilers. The villus height and the villus height/crypt depth ratio of the jejunum showed significant quadratic effects with the increasing concentration of SeNPs (P < 0.05). The mRNA expression of zonula occluden-1 (ZO-1), ZO-2, claudin-3, and claudin-5 in the jejunum decreased linearly with the increasing dose of SeNPs (P < 0.05). The mRNA expression levels of interleukin 1 beta (IL-1β), IL-18, and the concentration of reactive oxygen species (ROS) in the jejunum decreased linearly with the increase of SeNPs concentration (P < 0.05). Compared with the control group, the number of goblet cells in the jejunum was significantly increased by adding 0.1 and 0.4 mg/kg SeNPs(P < 0.05). In addition, the mRNA expression of Mucin2 (Muc2) showed a significant quadratic relationship that increased after adding 0.1 mg/kg SeNPs (P < 0.05). Dietary SeNPs also linearly reduced the expression of v-myc avian myelocytomatosis viral oncogene homolog (c-myc) (P < 0.05). The mean density of TUNEL positive cells in the 0.2 and 0.4 mg/kg SeNPs groups were lower than the control group (P < 0.05). Similarly, the mRNA expression levels of B-cell lymphoma-2 (Bcl-2), Bcl-2-associated X (Bax), NLR family pyrin domain containing 3 (NLRP3), cysteinyl aspartate specific proteinase-1 (Caspase-1), toll-like receptor-2 (TLR-2), and myeloid differentiation factor 88 (MyD88) in the jejunum decreased linearly with the increase of SeNPs concentration (P < 0.05). Results show that supplementation with 0.2 mg/kg SeNPs may decrease intestinal oxidative stress and inflammation by modifying the activation of NLRP3 signaling pathway, which can effectively promote intestinal goblet cells of 21-day-old broilers.
Detection of SARS-CoV-2 in peritoneal uid from patients with kidney disease and COVID-19: report of two cases

Margarita Ibarra-Hernandez Hospital Civil de Guadalajara "Fray Antonio Alcalde" María de la Luz Alcantar-Vallín Hospital Civil de Guadalajara "Fray Antonio Alcalde" Rodolfo I. Cabrera-Silva Universidad de Guadalajara Karina Sánchez-Reyes Universidad de Guadalajara Monserrat Alvarez-Zavala Universidad de Guadalajara Judith C. De Arcos-Jiménez Universidad de Guadalajara Luz A. González-Hernández Universidad de Guadalajara Vida V. Ruiz-Herrera Universidad de Guadalajara Sara A. Aguirre-Díaz Hospital Civil de Guadalajara "Fray Antonio Alcalde" Roxana García-Salcido Hospital Civil de Guadalajara "Fray Antonio Alcalde" Guillermo García-García Hospital Civil de Guadalajara "Fray Antonio Alcalde" Jaime F. Andrade-Villanueva (  hivlab16@outlook.com ) Universidad de Guadalajara
MOTHERS WITH BPD: PARENTING AND OFFSPRING OUTCOMES

There is growing interest in whether parenting strategies of mothers with borderline personality disorder (BPD) and offspring outcomes differ from those without BPD. We searched PsychINFO, PubMed, EMBASE, Web of Science, Scopus and ASSIA databases for studies examining parenting in mothers with BPD and/or offspring outcomes. PRISMA reporting guidelines were followed. Of 10067 abstracts screened, 101 full-text articles were retrieved and 33 met pre-determined criteria for qualitative synthesis. Overall, studies suggest that mothers with BPD are more likely to engage in maladaptive interactions with their offspring, characterised by insensitive, overprotective, hostile parenting than those without BPD. Adverse offspring outcomes include BPD symptoms, internalising (including depression), externalising problems, insecure attachment patterns, and emotional dysregulation. Findings suggest that vulnerability from mother to offspring may be partly transmitted via maladaptive parenting and maternal emotional dysfunction. Conclusions were limited by study heterogeneity in methodology and construct definitions, and a paucity of clinical comparison. Prospective studies of mothers with BPD and their offspring from pregnancy onwards may further elucidate mechanisms of transmission and identify resilience factors across development. Parenting behaviour awareness, improving attachment behaviours and emotional regulation strategies may be important intervention targets. MOTHERS WITH BPD: PARENTING AND OFFSPRING OUTCOMES
Biosynthesis of (Bacterio)chlorophylls: ATP-Dependent Transient Subunit Interaction and Electron Transfer of Dark Operative Protochlorophyllide Oxidoreductase

Dark operative protochlorophyllide oxidoreductase (DPOR) catalyzes the lightindependent two electron reduction of protochlorophyllide a to form chlorophyllide a, the last common precursor of chlorophyll a and bacteriochlorophyll a biosynthesis. During ATP-dependent DPOR catalysis the homodimeric ChlL2 subunit carrying a [4Fe-4S] cluster, transfers electrons to the corresponding heterotetrameric catalytic subunit (ChlN/ChlB)2 which also possesses a redox active [4Fe-4S] cluster. To investigate the transient interaction of both subcomplexes and the resulting electron transfer reactions, the ternary DPOR enzyme holocomplex comprising subunits ChlN, ChlB and ChlL from the cyanobacterium Prochlorococcus marinus was trapped as an octameric (ChlN/ChlB)2(ChlL2)2 complex after incubation with the non hydrolyzable ATP analogs adenosine5’(γ-thio)-triphosphate, adenosine-5’(βγimido)-triphosphate or MgADP in combination with AlF4. Additionally, a mutant ChlL2 protein, with a deleted Leucine in the switch-II region also allowed for the formation of a stable octameric complex. Furthermore, efficient complex formation required the presence of protochlorophyllide. Electron paramagnetic resonance spectroscopy of ternary DPOR complexes revealed a reduced [4Fe-4S] cluster located on ChlL2, indicating that complete ATP hydrolysis is a prerequisite for intersubunit electron transfer. Circular dichroism spectroscopic experiments indicated nucleotide-dependent conformational changes for ChlL2 after ATP binding. A nucleotide-dependent switch mechanism triggering ternary complex formation and electron transfer was concluded. From these results a detailed redox cycle for DPOR catalysis was deduced.
RUNNING HEAD: Group Identification and Attitude Restoration Group Identification as a Means of Attitude Restoration Group Identification and Attitude Restoration 2 Highlights

This paper investigates the possibility that individuals selectively identify with groups as a means of restoring certainty in their attitudes. Specifically, we contend that (i) groups offer social validation in the form of attitudinal norms, (ii) individuals heighten their identification with groups that offer norms that are consistent with attitudes that have been undermined, and (iii) access to these norms reduces attitude uncertainty. Two experiments support this hypothesis by demonstrating greater identification following a loss of attitude certainty, though only with groups offering relevant attitudinal norms. Moreover, this identification is subsequently shown to promote attitude restoration in the form of increased certainty. Consequently, groups serve an important role in attitude restoration by protecting attitudes against uncertainty when a relevant group is available to bolster the attitude.
Effects of Dietary Supplementation with Copper Sulfate or Tribasic Copper Chloride on Broiler Performance, Relative Copper Bioavailability, and Oxidation Stability of Vitamin E in Feed 1

An experiment was conducted using a total of 420, 1-d-old, Arbor Acres commercial male chicks to compare copper sulfate and tribasic copper chloride (TBCC) as sources of supplemental copper for broilers. Chicks were randomly allotted to 1 of 7 treatments for 6 replicates of 10 birds each and were fed a basal corn-soybean meal diet (11.45 mg/kg copper) supplemented with 0, 150, 300, or 450 mg/kg copper from copper sulfate or TBCC for 21 d. Chicks fed 450 mg/kg copper as copper sulfate had lower ( P < 0.01) average daily feed intake and average daily gain than those consuming other diets. Feeding supplemental copper increased linearly ( P < 0.0001) liver copper concentrations regardless of copper source. The slopes of regressions of log 10 liver copper on different independent variables used in regressions differ ( P < 0.05) between the 2 copper sources. Linear regression
INTEGRATED PHOTONICS TO THE RESCUE OF FEMTOSECOND BEAM DIAGNOSTICS

Beam instrumentation has always been using results from neighbouring communities. Over the last 10 years, a number of beam instruments and systems have successfully adopted optical solutions, pushing performances from ps to fs, exploiting optical set-ups or photonic components. A major advance for beam diagnostics and instrumentation was the introduction of an optical pulsed timing distribution system using low jitter mode-locked lasers. An outlook on future advances using integrated optical components will be given. The ultra low jitter optical pulse trains already present in today’s facilities may also lend themselves to advanced photonic analog-to-digtial convertors. Progress towards such devices especially in a practical integrated format and first demonstra-tions are discussed.
Solar Concentration for Wastewaters Remediation: A Review of Materials and Technologies

As the effectiveness of conventional wastewater treatment processes is increasingly challenged by the growth of industrial activities, a demand for low-cost and low-impact treatments is emerging. A possible solution is represented by systems coupling solar concentration technology with advanced oxidation processes (AOP). In this paper, a review of solar concentration technologies for wastewater remediation is presented, with a focus on photocatalyst materials used in this specific research context. Recent results, though mostly on model systems, open promising perspectives for the use of concentrated sunlight as the energy source powering AOPs. We identify (i) the development of photocatalyst materials capable of efficiently working with sunlight, and (ii) the transition to real wastewater investigation as the most critical issues to be addressed by research in the field.
Vascular Stat3 Promotes Angiogenesis and Neuroplasticity Long-Term After Stroke

Center for Stroke Research Berlin, Charite-Universitatsmedizin Berlin, Germany; Dept of Neurology, Charite-Universitatsmedizin Berlin, Germany; Max-Delbruck Center for Molecular Medicine, Berlin, Germany; Institute of Clinical Neurobiology, University Hospital, University of Wurzburg, Germany; Cluster of Excellence NeuroCure, Charite-Universitatsmedizin Berlin, Germany; German Center for Neurodegenerative Diseases (DZNE), Partner Site, Berlin, Germany; German Center for Cardiovascular Diseases (DZHK), Partner Site, Berlin, Germany
Clinical Implications of Distal Vessel Stenosis After Successful Coronary Chronic Total Occlusion Recanalization

in refined modified Miller score remains to be determined. Methodologically, the final value achieved might be more appropriate than percentage reduction for assessment of benefit. In our meta-analysis of USCDT, the standardized paired differences for improvements in RV/LVr and obstruction scores were 45% and 42%, respectively (2). Moreover, our 5-year experience with USCDT revealed that RV/LVr change was comparable with that in the present trial, while the Qanadli score improved by 62% (3). We also documented that percentage change in Qanadli score showed a mild correlation to percentage improvement in RV/LVr, and only changes in QS, not those in RV/LVr, showed significant interactions with lytic dose (3). The absence of comparisons in relation to age, baseline risk, and therapeutic strategy should also be considered important limitations. Low morbidity and mortality rates might represent a low-risk population, but not real-life outcomes in overall patients at intermediate to high risk. Moreover, in the era of effective anticoagulant regimens, low pulmonary embolism recurrence rates could not be attributed solely to the impact of USCDT.
Experimental Investigation of Vortex-Induced Vibrations Using 3D-Accelerometry and Digital Image Correlation

Tower structures of wind turbines are often installed in various conﬁgurations at the port before being transported by ships. Vortex-induced vibrations may occur when the natural frequency of the structure is close to ﬂow vortex shedding frequency. This leads to a considerable reduction of their fatigue life. The phenomenon is well-known for risers in the oil and gas industry. Here, we present an experimental study of vortex-induced vibrations (VIV) of a fully and partially submerged hollow cylinder in water. A circulating water channel generated the ﬂow towards the test bodies. Two hollow cylinders with a length-to-diameter ratio ( l/d ) of 28 . 13 and 18 . 5 and an outer diameter of 32 mm were used. Each cylinder was equipped with three-dimensional accelerometers. From the acceleration data, a two-fold integration delivered the motion amplitudes of the cylinders at the location of the accelerometer. In addition, a speckle pattern was applied to the cylinders and captured with two high-speed cameras, arranged in diﬀerent orientations to the cylinder. Three-dimensional Digital Image Correlation (DIC) was used to measure the motion trajectories for the areas of the cylinder, covered by a speckle pattern. First, decay tests for the test bodies were performed in air and water. From the motion trajectories, the natural frequencies and damping coeﬃcients were evaluated. Second, tests in uniform ﬂow were conducted under fully and partially submerged conditions for diﬀerent ﬂow velocities. Flow eﬀects such as reduced velocity on vibration were assessed in terms of motion amplitudes and frequencies in longitudinal and transverse direction. The results from DIC and accelerometer measurements were compared and the suitability of DIC for VIV
Force Haptic Interaction for Room-Scale 3 D Painting by

Artistic painting involves mastery of haptic interaction with tools. Each tool brings unique physical affordances which determines an aesthetic expression of the finished work. For instance, a pen offers an ability to make a precise stroke in a realism painting, whereas a thick brush or a sponge works perfectly with dynamic arm movement in the abstract art such as action painting. Yet the selection of a tool is just a beginning. It requires repetitive training to understand the full capability of the tool affordance and to master the painting of preferred aesthetic strokes. Such physical act of an artistic expression cannot be captured by the computational tools today. Due to the increasing market adoption of augmented reality and virtual reality, and the decades of studies in haptics, we see an opportunity for advancing 3D painting experiences in non-conventional approach. In this research, we focus on force haptic interaction for 3D painting art in a room-scale virtual reality. We explore virtual tangibility and tool affordance of its own medium. In addition to investigating the fidelity of a physical interactivity, we seek ways to extend the painting capabilities by computationally customized force feedback and metaphor design. This system consists of a wearable force feedback device that sits on user’s hand, a software for motor control and real-time 3D stroke generation, and their integration to VR platform. We work closely with an artist to refine the 3D painting application and to evaluate the system’s usability.
MANAGEMENT OF OVERABUNDANCE IN HETEROGENEOUS WIRELESS SENSOR NETWORKS

— we develop a novel probability model to analyze the best redundancy level in terms of path redundancy and source redundancy, as well as the best intrusion detection settings in terms of the number of voters and the intrusion invocation interval under which the lifetime of a HWSN is maximized. The key concept of our redundancy management is to exploit the tradeoff between energy consumption vs. the gain in reliability, timeliness, and security to maximize the system useful lifetime. We formulate the tradeoff as an optimization problem for dynamically determining the best redundancy level to apply to multipath routing for intrusion tolerance so that the query response success probability is maximized while prolonging the useful lifetime. In this paper we propose redundancy management of heterogeneous wireless sensor networks (HWSNs), utilizing multipath routing to answer user queries in the presence of unreliable and malicious nodes. Furthermore, we consider this optimization problem for the case in which a voting-based distributed intrusion detection algorithm is applied to detect and evict malicious nodes in a HWSN. We then apply the analysis results obtained to the design of a dynamic redundancy management algorithm to identify and apply the best design parameter settings at runtime in response to environment changes, to maximize the HWSN lifetime.
Structure and expression properties of the endo- L -1,4-glucanase A gene from the ¢lamentous fungus Aspergillus nidulans

Endo- L -1,4-glucanase A (EG A) of Aspergillus nidulans was purified to homogeneity, and its genomic gene ( eglA ) was cloned based on partial amino acid sequences of the purified enzyme and sequenced. The eglA gene comprised 1228 bp with four putative introns and encoded a polypeptide of 326 amino acids bearing high homology to the family A cellulases. The eglA promoter activity in A. nidulans was examined using the A. oryzae Taka-amylase A gene as a reporter. Expression of the reporter gene was induced by carboxymethylcellulose and cellobiose, and repressed by glucose, galactose, mannose, xylose, sorbitol, glycerol and succinate. Lactose neither induced nor repressed the expression. z 1999 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
Alfardus, Huda and McIntyre, Alan and Smith, Stuart J. (2017) MicroRNA regulation of glycolytic metabolism in glioblastoma multiforme. BioMed Research 2017 2314-6133

Glioblastoma multiforme (GBM) is the most aggressive and common malignant brain and central nervous system tumour. A well-known hallmark of GMB, and many other tumours, is aerobic glycolysis. microRNAs (miRNAs) are a class of short non-protein coding sequences that exert post-transcriptional controls on gene expression and represent critical regulators of aerobic glycolysis in GBM. In GBM, miRNAs regulate the expression of glycolytic genes directly and via the regulation of metabolism-associated oncogenic pathways, such as the PI3K/Akt signalling pathway. The aim of this review is to establish links between miRNA expression levels, disease grade and prognosis, and the glycolytic phenotype of GBM. In this review, the involvement of 25 miRNAs in the regulation of glycolytic metabolism of GBM is discussed. Seven of these miRNAs have been shown to regulate glycolytic metabolism in other tumour types. Further eight miRNAs, which have been shown to be differentially expressed in GBM, were also reported to play a regulatory role in glycolysis in other cancer types. Such miRNAs could serve as potential glycolytic regulators in GBM but require functional validation. This review concludes with presenting a number of glycolytic regulatory miRNAs that have demonstrated their therapeutic potential either alone or as adjuvants in GBM, despite the major challenges that have to be solved before miRNA-based therapies can widely be used for the treatment of GBM patients.