Miracle-dz/UniFAR-FTUs huggingface dataset:
neurocognitive function, and fatigue in patients with hepatitis C. Neurol Neuroimmunol

We recently reported age-related increases in left precuneus cortical thickness (CT) in older adults with elevated total depressive symptoms. However, it is unclear whether abnormalities in precuneus surface area (SA) are also evident and whether specific symptom dimensions of depression moderated age effects on these measurements. Seventy-three adults completed the Beck Depression Inventory – 2 nd edition (BDI-II) and underwent structural neuroimaging. Measures of CT and SA were extracted from the right and left precuneus via FreeSurfer. Regression models included regions of interest as dependent variables, with age, BDI-II subscale scores (e.g., affective, cognitive, and somatic symptoms), and their interactions as independent variables, controlling for mean hemispheric thickness (for CT) or total intracranial volume (for SA). A significant age × somatic symptom interaction was found for left precuneus CT, such that elevated levels of somatic symptoms were significantly associated with age-related cortical thinning. No depressive symptom dimensions moderated the relationship between age and SA, suggesting that CT may be a more sensitive measure of brain abnormalities in middle-aged to older adults with depressive symptoms.
Chan-Vese Model with Semi-Implicite AOS Scheme for Images Segmentation: Biphase and Multiphase Cases

—Active contour models are designed to evolve an initial curve, called level set, to extract the desired object(s) in an image. Various models are used, such as Chan-Vese (CV) model. The CV model has the global segmentation property to segment all objects in an image. The problem with this model is the high time computing. In order to reduce it, our contribution in this work is the association of a semi-implicit Additive Operator Splitting (AOS) technique with the CV model in biphase and multiphase cases. In this paper, we present the new association in biphase and multiphase cases with simulations showing the efﬁciency of the proposed method.
COMPARISION OF SALIVARY CORTISOL LEVELS IN NORMAL AND SEVERELY DEPRESSED INDIVIDUALS

: Background: Depression is a mood disorder characterized by sadness, inactivity, difficulty in thinking and concentration, feeling of hopelessness, and suicidal ideation. A type of depression is major depressive disorder which is signified by various characteristic features which have a strong impact on the person ’ s over all personality (1). Cortisol is secreted by the adrenal cortex and is considered as a stress hormone. Recent studies have shown that cortisol levels are increased in severe depression and these higher levels can be detected in the saliva samples. Aims and Objectives: We compared the salivary cortisol levels of in normal and severely depressed patients. Materials and Methods: After getting approval from Ethical committee, this cross sectional-analytical study was conducted in Department of Physiology, Shaikh Zayed FPGMI, and Punjab Institute of Mental Health Lahore. Study was Cross-sectional, comparative and 60 participants were included in this study; 30 in control group and 30 in study group. Diagnosed cases of major depression were selected based on outdoor clinical assessment and confirmed by ICD-10 and DSM-4 criteria. Cases of hyperaldosteronism, Cushing ’ s syndrome/disease were excluded from the study. Data were collected in the form of a questionnaire based on the Becks Inventory. Saliva samples were taken, processed and assessed for cortisol levels using ELISA kits. Results : Higher salivary cortisol was found in participants who were depressed with positive family history The mean cortisol level in normal subjects was 1.46±0.91
GPPS-NA-2018-113 Intake Geometry and Shear Layer Ingestion Effects on Embedded Propelling Fan Performance

This work presents an experimental investigation for the effects of three-dimensional flow phenomena, which unfold at boundary layer ingestion (BLI) aero-engine intakes of S-shaped geometry, on the performance of a one-stage multi fan compressor unit. The experimental setup consists of two groups of fans: the first one simulates the cruise velocity, while the second one constitutes the compressor unit. Three cases are examined: a straight duct intake as the baseline case and two S-shaped cases. The variable parameter which alters through an inherent mechanism is the length over height ratio (L/H) that characterizes the intake geometry. Oil and dye visualization method is used at the suction area upstream of the compressor unit array for the various intake shapes. Total and static pressure measurements are also performed at the aerodynamic interface plane (AIP) and cross section areas across the intake. This is achieved with a pneumatic five-hole probe which is built and calibrated at the Laboratory of Fluid Mechanics and Turbomachinery of Aristotle
An Enhanced Formative Assessment and Self-Regulated Learning Program: From the Classroom to the Workplace

Effective instruction in the classroom and training/evaluation in the workplace have been the focus of countless approaches and claims, not all of them contained within a complete theory of learning or substantiated with the appropriate research. This article will describe an Enhanced Formative Assessment Program that uses the self-regulated learning (SRL) model. SRL teaches students and workers to become more efficient and effective learners through a three stage cyclical process. The first planning stage teaches the learner how to set goals, select appropriate strategies, and make efficacy judgments. The second practice stage teaches them how to monitor their progress in real time. And the third evaluation stage allows learners to measure how close they came to achieving their goal, and more importantly, sets the stage for the next SRL cycle so that they can make additional progress. We will more fully describe the model and the research that supports its efficacy in the classroom as well as its potential applications to the workplace.
Data Rate Estimation

In an autonomous radio operation setting, one of the first parameters that we would like to estimate reliably would be the data rate of the received signal. Knowledge of this parameter is required to carry out maximum-likelihood (ML) detection [1] of other parameters, such as the carrier phase or modulation type. Although ML estimation of the data rate itself is statistically optimal, given that there is little to no a priori knowledge of the incoming signal, this approach is often difficult if not impossible to do in practice. One mitigating factor for the autonomous radio under consideration is the fact that the data rates are assumed to come from a set of known values, such as the data rates used in the Electra radio (see [2] and Chapter 2). In particular, the data rates here are assumed to be related by integer powers of an integer base B. This assumption, as will soon be shown, allows us to estimate the true data rate based on estimates of the signal-to-noise ratio (SNR) computed for various assumed data rates. The method for estimating the SNR here is the split-symbol moments estimator (SSME) discussed in [3] and Chapter 6. This estimator is appealing in that the only parameter required for its operation is the assumed data rate. Hence, estimation of the data rate can be done jointly with that of the SNR. Although this approach provides us with a way to estimate both the data rate and SNR together, it will be shown that it is sensitive to symbol-timing error or jitter. In fact, the presence of symbol-timing error can severely degrade the performance of this estimator, as shown in Chapter 6. To overcome this, a modification is proposed in which the jitter is quantized and estimated alongside the data rate and SNR. This approach, based on a so-called generalized likelihood ratio test (GLRT) [4], is robust in the presence of symbol-timing error and
Involvement of Dock8 in a Paracentric Inversion Affecting the Derivative Chromosome 9 in a Case of Philadelphia Positive Chronic Myeloid Leukemia

Chronic Myeloid Leukemia (CML) is a myeloproliferative disease in which the presence of the BCR-ABL1 fusion gene is the major criterion for diagnosis, consistently associated with specific clinical, laboratory and morphological features. Some cases present with a variant t(9;22) translocation, involving one or more chromosomes. Here we describe a 66 year-old woman with CML showing a variant t(9;22)(q34.12;q11.23) translocation. Classical cytogenetic analysis displayed the presence of additional chromosomal material of unknown origin at the telomere of the short arm of the derivative chromosome 9 [der(9)]. FISH experiments revealed that this material derived from chromosome 22. Using appropriate bacterial artificial chromosome probes, we disclosed that DOCK8 (9p24.3) was interrupted by a paracentric inversion breakpoint on the short arm of der(9). The partner breakpoint was located within the translocated sequence of BCR that was then juxtaposed to DOCK8 , without the formation of any fusion gene. As observed by real-time quantitative PCR, DOCK8 was not significantly altered in its expression levels, although we could not exclude the coding of truncated DOCK8 transcript isoforms produced because of the rearrangement. Interestingly, this gene was described as homozygously deleted in many cancer types, suggesting a possible role of this gene as a tumor suppressor. To the best of our knowledge, this is the first report describing the involvement of DOCK8 in CML, although its role in the leukemogenesis requires further clarifications.
special communication In situ calibration and [H 1 ] sensitivity of the ﬂuorescent Na 1 indicator SBFI

Church. In situ calibration and [H 1 ] sensitivity of the ﬂuorescent Na 1 indicator SBFI. Am J Physiol Cell Physiol 280: C1623–C1633, 2001. —Despite the popularity of Na 1 -binding benzofuran isophthalate (SBFI) to measure intracellular free Na 1 concentrations ([Na 1 ] i ), the in situ calibration techniques described to date do not favor the straightforward determination of all of the constants required by the standard equation (Grynkiewicz G, Poenie M, and Tsien RY. J Biol Chem 260: 3440–3450, 1985) to convert the ratiomet-ric signal into [Na 1 ]. We describe a simple method in which SBFI ratio values obtained during a “full” in situ calibration are ﬁt by a three-parameter hyperbolic equation; the apparent dissociation constant ( K d ) of SBFI for Na 1 can then be resolved by means of a three-parameter hyperbolic decay equation. We also developed and tested a “one-point” technique for calibrating SBFI ratios in which the ratio value obtained in a neuron at the end of an experiment during exposure to gramicidin D and 10 mM Na 1 is used as a normalization factor for ratios obtained during the experiment; each normalized ratio is converted to [Na 1 ] i using a modiﬁcation of the standard equation and parameters obtained from a full calibration. Finally, we extended the characterization of the pH dependence of SBFI in situ. Although the K d of SBFI for Na 1 was relatively insensitive to changes in pH in the range 6.8–7.8, acidiﬁcation resulted in an apparent decrease,
Redox control of miRNAs and their targets in wheat

A Abstract 8 Possible redox control of miRNAs was investigated in wheat. One-day treatment of seedlings 9 with 10 mM H 2 O 2 resulted in decreased glutathione content and increased half-cell reduction 10 potential of the glutathione disulphide/glutathione redox pair and greater ascorbate peroxidase 11 activity compared to the control plants. These changes were accompanied by alterations in the 12 miRNA transcript profile, since 70 miRNAs with at least 1.5-fold difference in their 13 expression between control and treated (0, 3, 6 h) seedlings were identified. Their 86 target 14 genes were determined by degradome sequencing and 6808 possible additional target genes 15 were identified by bioinformatics tools. The H 2 O 2 -responsiveness (24 h treatment) of 1647 16 targets was also confirmed by transcriptome analysis. They are mainly related to the control 17 of redox processes, transcription and protein phosphorylation and degradation. In a time- 18 course experiment (0, 1, 3, 6, 9, 12, 24 h treatment) a correlation was found between the 19 levels of glutathione, other antioxidants and the transcript levels of the H 2 O 2 -responsive 20 miRNAs and their target mRNAs. This relationship together with the bioinformatics 21 modelling of the regulatory network indicate the glutathione-related redox control of miRNAs 22 and their targets, which allows the adjustment of the metabolism to changing environmental 23 conditions.
Quadriceps Muscle Function in Relation to Habitual Physical Activity and O

The relationship of quadriceps maximal muscle power (P max ), corresponding optimal shortening velocity ( y opt ), and relative fatigability (Pmax%D) to maximal oxygen uptake ( O 2 max) and habitual physical activity (PA) was examined in healthy community-dwelling subjects (29 women and 25 men) aged more than 65 years old. PA was evaluated by a questionnaire and expressed using two activity indices: mean habitual daily energy expenditure (MHDEE) and the daily energy expenditure corresponding to leisure time sports activities (Sports Activity). In women, P max correlated positively with O 2 max ( r 5 .56) and with Sports Activity (rho 5 .41). Both Sports Activity and P max were significant independent predictors of O 2 max and accounted for 62% of variance in O 2 max. In men, y opt was significantly negatively related to MHDEE ( r 5 –.59) and to Sports Activity (rho 5 –.40). Neither in women nor in men was Pmax%D correlated with O 2 max or PA indices. The different relationship of P max and y opt with O 2 max and PA indices suggests that habitual PA may be sufficient in active older women, but not in men, to positively influence quadriceps muscle function. These gender differences may suggest different approaches in exercise programming for elderly women and men. V̇
Tweedy, J. and Escriva, E. and Topf, Maya and Gompels, U. (2017) Analyses of tissue culture adaptation of human Herpesvirus-6A by whole genome deep sequencing redefines the reference sequence and identifies virus entry

Tissue-culture adaptation of viruses can modulate infection. Laboratory passage and bacterial artificial chromosome (BAC)mid cloning of human cytomegalovirus, HCMV, resulted in genomic deletions and rearrangements altering genes encoding the virus entry complex, which affected cellular tropism, virulence, and vaccine development. Here, we analyse these effects on the reference genome for related betaherpesviruses, Roseolovirus, human herpesvirus 6A (HHV-6A) strain U1102. This virus is also naturally “cloned” by germline subtelomeric chromosomal-integration in approximately 1% of human populations, and accurate references are key to understanding pathological relationships between exogenous and endogenous virus. Using whole genome next-generation deep-sequencing Illumina-based methods, we compared the original isolate to tissue-culture passaged and the BACmid-cloned virus. This re-defined the reference genome showing 32 corrections and 5 polymorphisms. Furthermore, minor variant analyses of passaged and BACmid virus identified emerging populations of a further 32 single nucleotide polymorphisms (SNPs) in 10 loci, half non-synonymous indicating cell-culture selection. Analyses of the BAC-virus genome showed deletion of the BAC cassette via loxP recombination removing green fluorescent protein (GFP)-based selection. As shown for HCMV culture effects, select HHV-6A SNPs mapped to genes encoding mediators of virus cellular entry, including virus envelope glycoprotein genes gB and the gH/gL complex. Comparative models suggest stabilisation of the post-fusion conformation. These SNPs are essential to consider in vaccine-design, antimicrobial-resistance, and pathogenesis.
Targeting : lessons

The UCD community has made this article openly available. Please share how this access benefits you. Your story matters! (@ucd_oa) Some rights reserved. For more information, please see the item record link above. Title Targeting poverty : lessons from monitoring Ireland’s National Anti-Poverty Strategy Author(s) Layte, Richard; Nolan, Brian; Whelan, Christopher T. Publication date 1999-07-14 Series ESRI Working Papers; No. 117
SOURCE PARAMETER AND B-VALUE ESTIMATION OF LOCAL EARTHQUAKES IN

The earthquake activities recorded by establishing 5 stations digital radio frequency network in Kumaun Himalaya has been used to estimate source parameters and b-value; the network stations were equipped with five short period triaxial (L4-3D) seismometers and one accelerometer (CMG-5T) deployed at Nainital. A majority of microearthquake events attributed between two major tectonic boundaries viz., the Main Boundary Thrust (MBT) in the South and the Main Central Thrust (MCT) in the North shed new light to understanding the nature of seismicity and their relation with regional tectonics of the region. The source parameters viz., seismic moment, source radius and stress drop of local earthquakes have been computed following Brune‟s earthquake source model (1970). The values of seismic moment (M o ), Source radius(r) and stress drop (Δσ) of micro seismic events vary from 7.52E+10 (Nm)
IRIS RECOGNITION SYSTEM AND COMPARISON OF FEATURE EXTRACTION METHODS

- Biometric is the study of physical traits or behavioral characteristics of human beings. Among the biometrics, iris has highly accurate, reliable characteristics and remains stable over a person life. Iris recognition is the most reliable and accurate biometric security system. There are three modules in it-preprocessing, feature extraction, and Feature matching. This paper compares GLCM and Wavelet Transform to reduce FAR and improve accuracy.
Lawrence Berkeley National Laboratory Recent Work Title Convolved substructure : analytically decorrelating jet substructure observables

A number of recent applications of jet substructure, in particular searches for light new particles, require substructure observables that are decorrelated with the jet mass. In this paper we introduce the Convolved SubStructure (CSS) approach, which uses a theoretical understanding of the observable to decorrelate the complete shape of its distribution. This decorrelation is performed by convolution with a shape function whose parameters and mass dependence are derived analytically. We consider in detail the case of the D2 observable and perform an illustrative case study using a search for a light hadronically decaying Z ′. We find that the CSS approach completely decorrelates the D2 observable over a wide range of masses. Our approach highlights the importance of improving the theoretical understanding of jet substructure observables to exploit increasingly subtle features for performance.
Distribution of lndole-3-Acetic Acid and the Occurrence of Its Alkali-Labile Conjugates in the Extraxylary Region of Pinus sylvestris Stems1

Free and conjugated indole-3-acetic acid (IAA) were measured by quantitative gas chromatography-selected ion monitoring-mass spectrometry in the extraxylary region of the stem of large Pinus sylvestris (L.) trees during the annual cycle of cambial activity and dormancy. The extraxylary region at the stem top and bottom was divided into 3 and 4 fractions, respectively, for the free IAA measurements, while the entire extraxylary region was extracted when the IAA-conjugates were analyzed. The effect on the distribution pattern of expressing IAA level as a concentration (per gram fresh weight or dry weight) and as total amount (per square centimeter) was examined. The IAA level was much higher in the cambial region than in the fractions that contained the nonfunctional phloem and the periderm. The largest IAA concentration occurred in the fraction that included the cambium, whereas the total amount of IAA was greatest in the phloem-containing fraction. The significance of the nonuniform radial distribution of IAA for estimating the IAA concentration in the cambial region is discussed in relation to how the cambial region is sampled. A slight longitudinal gradient in IAA concentration, decreasing from the top to the bottom of the stem, was observed
Tango1 spatially organizes ER exit sites to control ER export

secretory cargo from the endoplasmic reticulum (ER) takes place at specialized domains called ER exit sites (ERESs). In mammals, loss of TAN GO1 and other MIA/cTAGE (melanoma inhibitory activity/cutaneous T cell lymphoma– associated antigen) family proteins prevents ER exit of large cargoes such as collagen. Here, we show that Drosophila melanogaster Tango1, the only MIA/cTAGE family member in fruit flies, is a critical organizer of the ERES–Golgi inter‑ face. Tango1 rings hold COP II (coat protein II) carriers and Golgi in close proximity at their center. Loss of Tango1, present at ERESs in all tissues, reduces ERES size and causes ERES–Golgi uncoupling, which impairs secretion of not only colla‑ gen, but also all other cargoes we examined. Further supporting an organizing role of Tango1, its overexpression creates more and larger ERESs. Our results suggest that spatial coordination of ERES, carrier, and Golgi elements through Tango1’s multiple interactions increases secretory capacity in Drosophila and allows secretion of large cargo.
Passion for Precision (Nobel Lecture)

Optical frequency combs from mode-locked femtosecond lasers have revolutionized the art of counting the frequency of light. They can link optical and microwave frequencies in a single step, and they provide the long missing clockwork for optical atomic clocks. By extending the limits of time and frequency metrology, they enable new tests of fundamental physics laws. Precise comparisons of optical resonance frequencies of atomic hydrogen and other atoms with the microwave frequency of a cesium atomic clock are establishing sensitive limits for possible slow variations of fundamental constants. Optical high harmonic generation is extending frequency comb techniques into the extreme ultraviolet, opening a new spectral territory to precision laser spectroscopy. Frequency comb techniques are also providing a key to attosecond science by offering control of the electric field of ultrafast laser pulses. In our laboratories at Stanford and Garching, the development of new instruments and techniques for precision laser spectroscopy has long been motivated by the goal of ever higher resolution and measurement accuracy in optical spectroscopy of the simple hydrogen atom which permits unique confrontations between experiment and fundamental theory. This lecture recounts these adventures and the evolution of laser frequency comb techniques from my personal perspective.
Retailing technology: doconsumers care? Tecnología en el comercio al detalle: > les importa a los consumidores?

Purpose – Disruptive retailing technologies improve productivity and cost optimization, but there is a lack of academic literature about their effects on shoppers ’ perceptions and behaviors. This paper aims to develop and test aconceptualmodelregardingtheeffectsofretailtechnologyonstoreimageandpurchaseintentionsandtomeasurehowhumaninteractionservices(HIS)moderatethisrelationship.Tworelevantretailtechnologiesareexplored. Design/methodology/approach – The results of this study indicate that retailing technology has notable in ﬂ uences on consumer perceptions. Thus, shopping technologies improve store image perceptions andincrease purchaseintention, moderated byHIS. Research limitations/implications – Future ﬁ eld experiments in actual stores should attempt to corroboratetheresults of this study andoffer greater internalvalidity. Practical implications – The results should help reduce retailers ’ resistance to technology adoption. In- storetechnologycan help retailersleverage their storeimage andincrease purchase intentions. HIScould offer a bridge between consumers andnewtechnology. Originality/value – This paper is an original research paper, given that few research papers are experimentallybasedto measure consumer ’ s reactions to newtechnologyimplementation.