Miracle-dz/UniFAR-FTUs huggingface dataset:
All SMILES Variational Autoencoder for Molecular Property Prediction and Optimization

Variational autoencoders (VAEs) defined over SMILES string and graph-based representations of molecules promise to improve the optimization of molecular properties, thereby revolutionizing the pharmaceuticals and materials industries. However, these VAEs are hindered by the non-unique nature of SMILES strings and the computational cost of graph convolutions. To efficiently pass messages along all paths through the molecular graph, we encode multiple SMILES strings of a single molecule using a set of stacked recurrent neural networks, harmonizing hidden representations of each atom between SMILES representations, and use attentional pooling to build a final fixed-length latent representation. By then decoding to a disjoint set of SMILES strings of the molecule, our All SMILES VAE learns an almost bijective mapping between molecules and latent representations near the high-probability-mass subspace of the prior. Our SMILES-derived but moleculebased latent representations significantly surpass the state-of-the-art in a variety of fullyand semi-supervised property regression and molecular property optimization tasks.
University of Groningen Genetic and functional characterization of dpp genes encoding a dipeptide transport system in Lactococcus lactis Sanz,

The genes encoding a binding-protein-dependent ABC transporter for dipeptides (Dpp) were identified in Lactococcus lactis subsp. cremoris MG1363. Two (dppA and dppP) of the six ORFs (dppAdppPBCDF) encode proteins that are homologous to peptideand pheromone-binding proteins. The dppP gene contains a chain-terminating nonsense mutation and a frame-shift that may impair its function. The functionality of the dpp genes was proven by the construction of disruption mutants via homologous recombination. The expression of DppA and various other components of the proteolytic system was studied in synthetic and peptide-rich media and by using isogenic peptide-transport mutants that are defective in one or more systems (Opp, DtpT, and/or Dpp). In peptide-rich medium, DppA was maximally expressed in mutants lacking Opp and DtpT. DppA expression also depended on the growth phase and was repressed by tri-leucine and tri-valine. The effect of tri-leucine on DppA expression was abolished when leucine was present in the medium. Importantly, the Dpp system also regulated the expression of other components of the proteolytic system. This regulation was achieved via the internalization of di-valine, which caused a 30–50% inhibition in the expression of the proteinase PrtP and the peptidases PepN and PepC. Similar to the regulation of DppA, the repressing effect was no longer observed when high concentrations of valine were present. The intricate regulation of the components of the proteolytic system by peptides and amino acids is discussed in the light of the new and published data.
SPATIAL AND TEMPORAL MODELING OF THE URBAN GROWTH AND LAND COVER CHANGES USING REMOTE SENSING, SPATIAL INDEXES AND GIS TECHNIQUES IN IRBID CITY, JORDAN

This study examined the temporal and spatial changes in the urban land cover of the northern region of Jordan from 2000 to 2020. Automated processing of satellite images was carried out and different statistical indicators were applied to analyze the data. The data facilitated the monitoring of urban sprawl and determination of trends based on the Geographic Information System (GIS) and remotesensing analysis of Landsat satellite images. The results revealed an increase in urban segments, population, and reverse migration compared to neighboring areas. The classified land use and land cover maps depicted an expansion of 19.22% from 2000 to 2010 and 8.04% from 2010 to 2020. In comparison to the areas at the urban saturation stage, more rapid urban growth was observed in the seven southwest and northwest districts. Thus, the study presents reliable information and a cartographic database to demonstrate the changes in urban cover of Irbid city, over the past 20 years.
Purification of Chorismate Lyase

In Escherichia coli, chorismate lyase catalyzes the first step in ubiquinone biosynthesis, the conversion of chorismate to 4-hydroxybenzoate. 4-Hydroxybenzoate is converted to 3-octaprenyl-4-hydroxybenzoate by 4-hydroxybenzoate octaprenyltransferase. These two enzymes are encoded by ubiC and ubi4, respectively, and have been reported to map near one another at 92 min on the E. coli chromosome. We have cloned the ubiCA gene cluster and determined the nucleotide sequence of ubiC and a portion of ubi4. The nucleotide sequence abuts with a previously determined sequence that encodes a large portion of ubi4. ubiC was localized by subcloning, and overproducing plasmids were constructed. Overexpression of ubiC allowed the purification of chorismate lyase to homogeneity, and N-terminal sequence analysis of chorismate lyase unambiguously defined the beginning of the ubiC coding region. Although chorismate lyase showed no significant amino acid sequence similarity to 4-amino-4-deoxychorismate lyase (4-amino-4-deoxychorismate -. 4-aminobenzoate), the product of E. coli pabC, chorismate lyase overproduction could complement the growth requirement for 4-aminobenzoate of a pabC mutant strain. Of the several enzymes that convert chorismate to intermediates of E. coli biosynthetic pathways, chorismate lyase is the last to be isolated and characterized.
OAEM_A_304153 177..182

1Department of Emergency Medicine, Hamad General Hospital, Doha, Qatar; 2University of Aberdeen School of Medicine and Dentistry, Aberdeen, Scotland, UK Introduction: Point of care ultrasound (POCUS) has been a part of emergency medicine (EM) training for almost two decades. EM training program has a very broad and rigorous POCUS curricula which, in several cases, does not translate to routine application in clinical settings. This study therefore sought to compare the indications, utilization, barriers, and preferred POCUS educational method in a large Middle Eastern academic EM. Methodology: A validated questionnaire was emailed to 50 EM faculties between April and May 2019. Volunteer faculty members partook in a semi-structured interview to better understand the indications, current use, barriers, and preferred learning method. Responses were anonymous, and data were analyzed with descriptive statistics. Results: This was a mixed design study. 30/50 (60%) of faculty responded to the survey, with a mean age of 39.2 years and a mean number of years in practice, 13.1. 55% (n=28) completed POCUS training in less than five years, while 45% completed more than five years ago and 5% never completed it. Forty percent of EM physicians were trained in Africa, while 55% were qualified in Asia and 5% completed their training in Europe. The indications and frequently performed procedures were consistent with the previous research. The common barrier reported was lack of time, lack of credentialing, lack of quality assurance, and national guidelines. The majority of the faculty preferred a blended learning approach for POCUS. Conclusion: POCUS perceived barriers to its full use include time constraints, lack of national guidelines, and credentialing (awarding POCUS qualifications) of the faculty. Blended learning appears to be the preferred approach towards acquiring the knowledge and skills of POCUS.
Multipurpose Street Smart Garbage bin based on Iot

: The government of India aims at “Swachh Bharat Mission” and for that we need smart city with smart streets enabled with smart garbage monitoring system. We see garbage bins around us placed at public places overflowing with due to increase in waste and results into unhygienic conditions for people and leads to deadly diseases. Thus to improve this situation, we proposed this project. In our proposed system, there are multiple smart garbage trash bins on a microcontroller board platform (Arduino Board) located throughout any city or the campus or hospital. The Arduino Board is interfaced with GSM modem and ultrasonic sensor. Once the level of threshold is being crossed, then ultrasonic sensors will trigger the GSM module which in turn continuously alert the authorised perso n by sending SMS reminder after until the dustbin is cleaned. Beside this, we will also create the central system that will keep showing us the current status of garbage on mobile web browser with html page by wi-fi. With the help of this, we will create shortest path for garbage collection vehicles using Dijkstra Algorithm. This is real time waste management by using smart trash bins that can be accessed anytime anywhere by the concerned person.
HEDY LAMARR AND FREQUENCY HOPPING

This paper reconsiders the question of the role of Hedy Lamarr in Frequency Hopping technique, taking as a starting point the historical and descriptive accounts on the items under consideration. By way of illustration, the paper examines the pertinence of Frequency Hopping and Spread Spectrum mainly in the descriptively-oriented manner and based on the literature on the subject. This paper is built around six parts. The paper opens with an introduction that sets the scene. It sketches out the scientific contribution of Hedy Lamarr. The second part provides some introductory remarks on Hedy Lamarr as an inventress. The third part recasts certain aspects of Hedy Lamarr’s contribution to the invention of Frequency Hopping by moving from the centre and working outwards. The fourth part is a sketchy exercise of simple structures serendipitously leading to complex ideas thereby recounting Spread Spectrum and Frequency Hopping. The fifth part is more empirical in nature in that it outlines some linguistic aspects of Frequency Hopping Patent by means of first and foremost structural linguistic analysis. A brief discourse analysis was aimed to show that some language items may be used to account for this discourse type, or text type, i.e. the analysed patent text. In this way, the analysed historical-descriptive engineering and linguistic aspects are brought together to elucidate the overall contribution of Hedy Lamarr in the former and current domain of Frequency Hopping.
Saving Energy on Edge: In-Memory Caching for Multi-Tier Heterogeneous Network

Recent years have witnessed billions of new manufactured sensors, equipments and machines being connected to our almost omnipotent Internet. While enjoying the comfort and convenience brought by Internet of Things (IoT), we also have to face tremendous energy consumption and carbon emissions which even cause climate deterioration. Extended from cloud computing, edge/fog computing and caching provide new thoughts on processing big data generated from distributed IoT devices. With the purpose to help deal with the data explosion problem by edge caching, in this paper we apply in-memory storage & processing to reduce energy consumption. We design two kinds of Time to Live (TTL) in four cache replacement policies to cache data at edge. We carry out simulation experiment in a 3-tier heterogeneous network structure using Random Waypoint (RWP) model and test the performance of in-memory caching and traditional method. The analysis results manifest that our in-memory method is able to obtain better energy efficiency in edge caching and has stable & low backhaul rate.
APPLIED PHYSICAL MODELING FOR SOUND SYNTHESIS: THE YAYBAHAR

In this paper, finite-difference time-domain methods are adopted to model a specific instrument, the Yaybahar, invented by Turkish artist Görkem Şen. Each part of the instrument is simulated independently and its physical behavior is explained in an intuitive yet accurate manner. The models are implemented in C++ to form an interactive, real-time application. Code and sound samples are available online.
Running Title : Amine oxidases in root xylem development 4 5 Corresponding author 6

1 Manuscript for Plant Physiology (Resubmission) 2 3 Running Title: Amine oxidases in root xylem development 4 5 Corresponding author 6 Alessandra Cona 7 Dipartimento di Scienze, 8 Università Roma Tre, 9 00146 Roma, 10 Italy 11 Phone: +390657336360 12 e-mail: alessandra.cona@uniroma3.it 13 14 Research Area: 15 Signaling and Response 16 Plant Physiology Preview. Published on April 17, 2015, as DOI:10.1104/pp.15. 00121
PROFITABILITY AND BANK STABILITY: EMPIRICAL EVIDENCE IN VIET NAM

Through the secondary data collected from 2014 to 2019, the research used Pool OLS, FEM, REM and GMM methods to test the impact of profitability on stability of Vietnam commercial bank system. The results show that profitability impact on Vietnam bank stability with high significant, in which liquidity, capital ratio, efficiency ratio, bank size have positive impact on profitability with a high significant. Non-performing loans have negative impact on profitability with a high significant on profitability. The results also show that bank size and capital ratio have a positive impact on bank stability with a high significant while credit risk have a negative relationship with bank stability. From the results obtained, the research proposed solutions for bank management strategy. Keywords— profitibility, bank stability, Vietnam bank system
Bank regulatory Capital Buffer and Liquidity: Evidence from US and European Publicly Traded Banks

The theory of financial intermediation highlights v arious channels through which capital and liquidity are interrelated. Using a sim ultaneous equations framework, we investigate the relationship between bank regulator y capital buffer and liquidity for European and U.S. publicly traded commercial banks. Previous research studying the determinants of bank capital buffer has neglected the role of liqui dity. On the whole, we find that banks do not strengthen their regulatory capital buffer when the y face higher illiquidity as defined in the Basel III accords or when they create more liquidit y as measured by Berger and Bouwman (2009). However, considering other measures of illi quidity that focus more closely on core deposits in the United States, our results show tha t small banks do actually strengthen their solvency standards when they are exposed to higher lliquidity. Our empirical investigation supports the need to implement minimum liquidity ra tios concomitant to capital ratios, as stressed by the Basel Committee; however, our findi ngs also shed light on the need to further clarify how to define and measure illiquidity and a lso on how to regulate large banking institutions, which behave differently than smaller ones. JEL classification: G21; G28
A Study of Demonstrative Determiners in Pashto

The existence of determiner phrases and their different manifestations in number, gender, and case have been studied and proved in English in many research studies. Many languages other than English need this investigation to establish a sound hypothesis about the universal language structure. This study was an attempt to find out the structure of the determiner phrase in the Pashto. It also investigated the equivalents of the English determiner phrase in the Pashto. It used the spoken corpus of Pashto as primary data. In addition, short stories and novels written by literary writers in the Pashto have been used as secondary data. Moreover, intensive group discussion with native speakers of Pashto has also been utilized as another secondary data source. The minimalist program was used to guide and understand the syntactic structure of languages. It was followed by the determiner phrase hypothesis. The hypothesis states that a noun is headed by its determiner in a noun phrase. Data were analyzed within the framework of the determiner phrase hypothesis. The study shows that a noun in the determiner phrase is not determined by a definite or indefinite article in Pashto. The determiner phrase is inflected for number, gender, and case in Pashto. Furthermore, the Pashto determiner phrase is different from English in terms of medial demonstrative determiners. The study is significant as it provides insight into the structure of the Pashto determiner phrase.
THE VIKING HRTF DATASET

This paper describes the Viking HRTF dataset, a collection of head-related transfer functions (HRTFs) measured at the University of Iceland. The dataset includes fullsphere HRTFs measured on a dense spatial grid (1513 positions) with a KEMAR mannequin with 20 different artificial left pinnae attached, one at a time. The artificial pinnae were previously obtained through a custom molding procedure from 20 different lifelike human heads. The analyses of results reported here suggest that the collected acoustical measurements are robust, reproducible, and faithful to reference KEMAR HRTFs, and that material hardness has a negligible impact on the measurements compared to pinna shape. The purpose of the present collection, which is available for free download, is to provide accurate input data for future investigations on the relation between HRTFs and anthropometric data through machine learning techniques or other state-of-the-art methodologies.
Growth and Welfare under Endogenous Lifetimes*

We study the role of endogenous healthcare choices by households to extend their expected lifetimes on economic growth and welfare in a decentralized overlapping generations economy with annuitized wealth. We characterize endogenous healthcare spending in the decentralized market equilibrium and its effects on economic growth, and we identify the moral-hazard effect in healthcare investments when annuity rates are conditioned on average mortality. In a numerical simulation of our model with OECD data from 2005, we find that the moral-hazard effect can be substantial and implies sizable welfare losses of approximately 1.4–2.8 percent, depending on the share of annuitized retirement wealth.
A Soft Three-Axis Force Sensor Based on Radially Symmetric Pneumatic Chambers

In physical human–machine interaction applications, the accurate measurement of interactive forces between the human and the machine plays a significant role. Sensors for this purpose should not only be accurate and reliable, but also be soft enough to guarantee the safe and compliant interaction. In this aspect, pneumatic sensors with soft air chambers have often been utilized as a soft force sensor system. Although the pneumatic-based force sensor provides a good compliance and softness, however, it measures only a lumped force acting on the chamber, because the pneumatic sensor measures the overall pressure change in the air chamber. In this paper, a three-axis force sensor with three air chambers in a radially symmetric pattern is proposed for the measurement of multi-dimensional interaction forces with high softness and compliance. Each air chamber embeds a pneumatic sensor, and the pressure changes in the three air chambers are measured in order to distinguish the direction of the applied force. By decoupling the sensor signals from the three pneumatic sensors, the three-dimensional force components can be calculated accurately. Consequently, the proposed sensor is able to measure the three-dimensional forces while maintaining the great softness and compliance provided by the soft air chambers. The design, the fabrication method, and the verification of the proposed method are introduced in this paper.
Inflammatory Protein-2 Expression in Sepsis Nitric Oxide Stimulates Macrophage

NO is a crucial mediator of the inﬂammatory response, but its in vivo role as a determinant of lung inﬂammation remains unclear. We addressed the in vivo role of NO in regulating the activation of NF- (cid:1) B and expression of inﬂammatory proteins using an in vivo mouse model of sepsis induced by i.p. injection of Escherichia coli . We observed time-dependent degradation of I (cid:1) B and activation of NF- (cid:1) B accompanied by increases in inducible NOS, macrophage inﬂammatory protein-2 (MIP-2), and ICAM-1 expression after E. coli challenge, which paralleled the ability of lung tissue to produce high-output NO. To determine the role of NO in this process, mice were pretreated with the NO synthase (NOS) inhibitor NG -methyl- L -arginine. Despite having relatively modest effects on NF- (cid:1) B activation and ICAM-1 or inducible NOS expression, the NOS inhibitor almost completely inhibited expression of MIP-2 in response to E. coli challenge. These responses were associated with the inhibition of migration of neutrophils in lung tissue and increased permeability induced by E. coli . In mice pretreated with NG -methyl- L -arginine, coadministration of E. coli with the NO donor ( Z )-1-[ N -(2-aminoethyl)- N -(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate substantially restored MIP-2 expression but decreased ICAM-1 expression. The results suggest that NO generated after administration of E. coli serves as an important proinﬂammatory signal to up-regulate MIP-2 expression in vivo. Thus, NO production in high quantities may be important in the mechanism to detect murine MIP-2 concentrations (cid:6) pg/ml. The did not cross-react with TNF- (cid:2) , IL-2, IL-4, IL-6, (cid:4) , other members of the murine chemokine family, murine JE/monocyte chemoattractant protein-1, MIP-1 (cid:2) , growth-related oncogene (cid:2) , ENA-78 (41). The anti-MIP-2 Abs also did not interfere with measurements of MIP-2 by
Peroxisome Proliferator–Activated Receptor (cid:1) Induces NADPH Oxidase Activity in Macrophages, Leading to the Generation of LDL with PPAR- (cid:1) Activation Properties

—Peroxisome proliferator–activated receptors (PPARs) are nuclear receptors controlling lipid and glucose metabolism as well as inflammation. PPARs are expressed in macrophages, cells that also generate reactive oxygen species (ROS). In this study, we investigated whether PPARs regulate ROS production in macrophages. Different PPAR- (cid:1) , but not PPAR- (cid:2) agonists, increased the production of ROS (H 2 O 2 and O 2 .) in human and murine macrophages. PPAR- (cid:1) activation did not induce cellular toxicity, but significantly decreased intracellular glutathione levels. The increase in ROS production was not attributable to inherent prooxidant effects of the PPAR- (cid:1) agonists tested, but was mediated by PPAR- (cid:1) , because the effects were lost in bone marrow–derived macrophages from PPAR- (cid:1) (cid:1) / (cid:1) mice. The PPAR- (cid:1) –induced increase in ROS was attributable to the induction of NADPH oxidase, because (1) preincubation with the NADPH oxidase inhibitor diphenyleneiodinium prevented the increase in ROS production; (2) PPAR- (cid:1) agonists increased O 2 . production measured by superoxide dismutase–inhibitable cytochrome c reduction; (3) PPAR- (cid:1) agonists induced mRNA levels of the NADPH oxidase subunits p47 phox , p67 phox , and gp91 phox and membrane p47 phox protein levels; and (4) induction of ROS production was abolished in p47 phox (cid:1) / (cid:1) and gp91 phox (cid:1) / (cid:1) macrophages. Finally, induction of NADPH oxidase by PPAR- (cid:1) agonists resulted in the formation of oxidized LDL metabolites that exert PPAR- (cid:1) –independent proinflammatory and PPAR- (cid:1) –dependent decrease of lipopolysaccharide-induced inducible nitric oxide synthase expression in macrophages. These data identify a novel mechanism of autogeneration of endogenous PPAR- (cid:1) ligands via stimulation of NADPH oxidase activity. ( Circ Res . 2004;95:1174-1182.)