Miracle-dz/UniFAR-FTUs huggingface dataset:
Designing a Data Logistics and Model Deployment Service

—In Big Data applications, it is often required to inte- grate data from different sources to fuel machine learning models. In this paper, we describe a prototype implementation of the data logistics and model deployment services. Our goal was to create a one stop shop solution to support generic Data Science life cycle. It starts from formalized and repeatable data selection and processing provided by the data logistic service. The data are used for model creation in a typical machine learning fashion. The model is then put into a model repository to enable easy model management, sharing, and deployment. The functionality of the proposed prototype is positively veriﬁed with a particular use case from environmental science.
Is a for

Both familial and sporadic porphyria cutanea tarda (PCT) are iron dependent diseases. Symptoms of PCT resolve when iron stores are depleted by phlebotomy, and a sequence variant of HFE (C282Y, c.843G > A, rs1800562) that enhances iron aborption by reducing hepcidin expression is a risk factor for PCT. Recently, a polymorphic variant (D519G, c.1556A > G, rs11558492 ) of glyceronephosphate O-acyltransferase ( GNPAT ) was shown to be enriched in male patients with type I hereditary hemochromatosis ( HFE C282Y homo-zygotes) who presented with a high iron phenotype, suggesting that GNPAT D519G, like HFE C282Y, is a modifier of iron homeostasis
ELECTROPHYSIOLOGICAL EVALUATION OF SUBCLINICAL NEUROPATHY IN DIABETES PATIENTS

Background: Diabetes mellitus is estimated to affect 23.6 million people in the United States and this number is much larger in India. The risk of developing symptomatic neuropathy in patients without neuropathic symptoms or signs at the time of diagnosis is estimated to be 4 % to 10 % by 5 years and upto 50 % by 25 years. Nerve conduction study is widely used for the diagnosis of diabetic neuropathy. Nerve conduction abnormalities exist in subclinical stages of neuropathy that can be detected at an early asymptomatic stage by various electrodiagnostic test. Because peripheral nerves have the capability to regenerate, early diagnosis and timely intervention will reduce the morbidity in diabetes. Materials and Methods: The study is conducted at government Rajaji Hospital, Madurai from April 2021 to April 2022. 30 patients diagnosed as diabetes, who were asymptomatic regarding neuropathy attending the diabetology outpatient department are examined at neurology outpatient department. Result: Regarding duration of diabetes, majority of the patients were between 2-5 years (50 %). Among the results compared with each of the CMAP and SNAP, it has been found that as HbA1C level higher, the number of patients showing subclinical nerve conduction abnormality including CMAP median, ulnar, peroneal and tibial nerves shows an increase in patients though not statistically significant. With regarding to HbA1C levels and SNAP, it has been found that SNAP median and sural nerve showed a statistically significant involvement of the nerves as the HbA1C levels raises. Conclusion: The present study is done to study the effect of diabetes in motor and sensory nerve conduction parameters in diabetes patients and to observe the functional status of peripheral nerve in asymptomatic diabetes patients. In the present study, almost all patients (26 out of 30 cases) had shown electrophysiological changes indicating that they may had subclinical neuropathy which stresses the importance of the nerve conduction study (NCS) in the diagnosis of subclinical neuropathy. Particularly in sustained hyperglycemia.
Engineering Resilience through Research Mentorship: Manufacturing Pathways to Careers

Dr. Lara Perez-Felkner is an Associate Professor of Higher Education and Sociology in the Higher Education Program within the College of Education at Florida State University. She is afﬁliated with FSU’s Center for Postsecondary Success, Temple University’s Center for College, Community, and Justice, and the international VHTO Network Gender + STEM. Her research uses developmental and sociological perspectives to examine how young people’s social contexts inﬂuence their college and career outcomes. She focuses on the mechanisms that shape entry into and persistence in institutions and ﬁelds in which they have traditionally been underrepresented. In particular, she investigates racial-ethnic, gender, and so-cioeconomic disparities in post-secondary educational attainment and entry to scientiﬁc career ﬁelds. Dr. Perez-Felkner’s work has been published in journals including New Directions in Institutional Research, Developmental Psychology, Frontiers in Psychology, Journal of Higher Education, Journal of Latinos and Education, and Teachers’ College Record, as well in several edited volumes and news outlets. Her work has been supported by external agencies, including the National Science Foundation. She leads multiple evaluation partnerships with NSF engineering grantees, is a member of STEM Central, and has participated in AAC&U PKAL inititatives around STEM equity. Chelsea is a in Higher Education, Student Affairs under the mentorship of Dr. Perez-Felkner. Her research explores the development of college students from a social ecological perspective. investigates underlying process-property-performance relationships that impact the life-cycle for advanced composite materials. The primary research focus lies in integrative and as-sisted processing developments for advanced composites through hybrid processing and multifunctional composite fabrication through multimaterial processing and digital manufacturing. Applications are di-rected at energy/stress conversion for integrated structural health monitoring, ﬁeld-assisted direct writing, storage/dissipation for resilient structuring, and electrochemical conversion for energy harvesting. He has 30+ and and applications with 5 disclosures (pending) in the areas of advanced multifunctional composites, sensory-scaled composite manufacturing (3D sensor integration), ubiquitous real-time structural health monitoring, and additive manufacturing.
Cooperative Binding of the Class I Major Histocompatibility Complex Cytoplasmic Domain and Human Immunodeﬁciency Virus Type 1 Nef to the Endosomal AP-1 Complex via Its (cid:2) Subunit (cid:1)

Human immunodeﬁciency virus type 1 Nef provides immune evasion by decreasing the expression of major histocompatibility complex class I (MHC-I) at the surfaces of infected cells. The endosomal clathrin adaptor protein complex AP-1 is a key cellular cofactor for this activity, and it is recruited to the MHC-I cytoplasmic domain (CD) in the presence of Nef by an uncharacterized mechanism. To determine the molecular basis of this recruitment, we used an MHC-I CD–Nef fusion protein to represent the MHC-I CD/Nef complex during protein interaction assays. The MHC-I CD had no intrinsic ability to bind AP-1, but it conferred binding activity when fused to Nef. This activity was independent of the canonical leucine-based AP-binding motif in Nef; it required residue Y320 in the MHC-I CD and residues E62-65 and P78 in Nef, and it involved the (cid:1) but not the (cid:2) / (cid:3) subunits of AP-1. The impaired binding of mutants encoding substitutions of E62-65 or P78 in Nef was rescued by replacing the Y320SQA sequence in the MHC-I CD with YSQL, suggesting that Nef allows the YSQA sequence to act as if it were a canonical (cid:1) -binding motif. These data identify the (cid:1) subunit of AP-1 ( (cid:1) 1) as the key target of the MHC-I CD/Nef complex, and they indicate that both Y320 in the MHC-I CD and E62-65 in Nef interact directly with (cid:1) 1. The data support a cooperative binding model in which Nef functions as a clathrin-associated sorting protein that allows recognition of an incomplete, tyrosine-based (cid:1) -binding signal in the MHC-I CD by AP-1.
reveals direct targets of gammaherpesvirus-induced mRNA decay suggests that multiple mechanisms govern cellular transcript escape.

One characteristic of lytic infection with gammaherpesviruses, including Kaposi’s sarcoma-associated herpesvirus (KSHV), Epstein-Barr virus (EBV) and murine herpesvirus 68 (MHV68), is the dramatic suppression of cellular gene expression in a process known as host shutoff. The alkaline exonuclease proteins (KSHV SOX, MHV-68 muSOX and EBV BGLF5) have been shown to induce shutoff by destabilizing cellular mRNAs. Here we extend previous analyses of cellular mRNA abundance during lytic infection to characterize the effects of SOX and muSOX, in the absence of other viral genes, utilizing deep sequencing technology (RNA-seq). Consistent with previous observations during lytic infection, the majority of transcripts are downregulated in cells expressing either SOX or muSOX, with muSOX acting as a more potent shutoff factor than SOX. Moreover, most cellular messages fall into the same expression class in both SOX- and muSOX-expressing cells, indicating that both factors target similar pools of mRNAs. More abundant mRNAs are more efficiently downregulated, suggesting a concentration effect in transcript targeting. However, even among highly expressed genes there are mRNAs that escape host shutoff. Further characterization of select escapees reveals multiple mechanisms by which cellular genes can evade downregulation. While some mRNAs are directly refractory to SOX, the steady state levels of others remain unchanged, presumably as a consequence of downstream effects on mRNA biogenesis. Collectively, these studies lay the framework for dissecting the mechanisms underlying the susceptibility of mRNA to destruction during lytic gammaherpesvirus infection. That
An Evaluation Model of Internal and External Contributions in Hierarchical Organizations

—Two typical but different types of organization exist: one is traditional organization with a pyramid shaped hierarchical structure, while the other is a network organization with a non- hierarchical structure. In the organization sciences and its allied ﬁeld including business administration, economics, public adminis- tration, sociology, and psychology, the behavioral patterns and values required in a speciﬁc organization have been discussed from the standpoint of being successful relative to other competing ﬁrms. From the examination of the literature, it is readily discernible that organizational studies on authority and layering have primarily been qualitative in nature. Organization theory suggests that to streamline the management of a large organization begins by dividing it into several sections. We propose a new mathematical model which deﬁnes internal and external contributions for the organizations in this paper. Consequently, the evaluation function in the new model is adapted by the sum of the contribution to the external of all members in a given organization. This paper offers two or more evaluation measures that are required for an organization to be specialized.
A Novel Opinion Reason Mining Framework Exploiting Linguistic Associations

—Abstract—Aspect-based Sentiment Analysis (ABSA) explores the strong and weak aspects of a product. There are many online platforms that allow users to review commercial products while others to aggregate those opinions across millions of reviews at the aspect level. Such analysis is of high regard to potential customers and manufacturers to make profitable decisions. However, the existing ABSA models do not highlight the reasons behind the strengths and weaknesses of the aspects. Moving a step forward, opinion reason mining explores the reasons for the aspects being appreciated or criticized. We propose opinion reason mining framework ORMFW that uses topic model to generate aspects as groups of aspect terms which are refined using paradigmatic word associations. Polarity is evaluated for each aspect using a dictionary based approach. Furthermore, it incorporates syntagmatic word associations to map the aspects to their respective reason terms against a sentiment polarity. Results on twitter dataset reveal that the proposed ORMFW framework efficiently and effectively identifies the prominent opinion reasons in relation to their aspects.
Reuse of Kansei Evaluation Results for the Aesthetic Design of Different Types of Products

Most of aesthetic design methods proposed in the field of kansei engineering ask customers to evaluate the same type of existing products as a design target, analyze the relationships between their results and aesthetic features and generate a new design desired by customers. Therefore, customers need to conduct a lot of kansei evaluations for each design and those evaluations become their heavy burden. To reduce customers’ burden, this paper proposes a method for reusing kansei evaluation results for the aesthetic design of different types of products. The basic idea of the proposed method is that the decision rules extracted from one type of product can be applied to others if they have the same aesthetic features. Therefore, once kansei evaluation results of various types of products are sufficiently collected, it becomes possible to design new products without additional kansei evaluation. In the case study, to demonstrate a design flow using the proposed method, low heel pumps and a long wallet were designed based on kansei evaluation results of penny loafers, high heels and sneakers. Low heel pumps are a type of women’s shoes like penny loafers, high heels and sneakers while a long wallet is different from them. The obtained designs were evaluated by subjects to reveal the properties / effectiveness of the proposed method.
Finger Domain Mutation Affects Enzyme Activity, DNA Replication Efﬁciency, and Fidelity of an Exonuclease-Deﬁcient DNA Polymerase of Herpes Simplex Virus Type 1 (cid:1)

The catalytic subunit of herpes simplex virus DNA polymerase (Pol), a member of the B family polymerases, possesses both polymerase and exonuclease activities. We previously demonstrated that a recombinant virus (YD12) containing a double mutation within conserved exonuclease motif III of the Pol was highly mutagenic and rapidly evolved to contain an additional leucine-to-phenylalanine mutation at residue 774 (L774F), which is located within the ﬁnger subdomain of the polymerase domain. We further demonstrated that the recom- binant L774F virus replicated DNA with increased ﬁdelity and that the L774F mutant Pol exhibited altered enzyme kinetics and impaired polymerase activity to extension from mismatched primer termini. In this study, we demonstrated that addition of the L774F mutation to the YD12 Pol did not restore the exonuclease deﬁciency. However, the polymerase activity of the YD12 Pol to extension from mismatched primer termini and on the nucleotide incorporation pattern was altered upon addition of the L774F mutation. The L774F muta-tion-containing YD12 Pol also supported the growth of viral progeny and replicated DNA more efﬁciently and more accurately than did the YD12 Pol. Together, these studies demonstrate that a herpes simplex virus Pol mutant with a highly mutagenic ability can rapidly acquire additional mutations, which may be selected for their survival and outgrowth. Furthermore, the studies demonstrate that the polymerase activity of HSV-1 Pol on primer extension is inﬂuenced by sequence context and that herpes simplex virus type 1 Pol may dissociate more frequently at G (cid:1) C sites during the polymerization reaction. The implications of the ﬁndings are discussed.
Joint and independent neurotoxic effects of early life exposures to a chemical mixture A multi-pollutant approach combining ensemble learning and g-computation

Background: Exposure to mercury (Hg) is associated with adverse developmental effects. However, Hg occurs with a multitude of chemicals. We assessed the associations of developmental exposure to multiple pollutants with children’s neurodevelopment using a novel approach. Methods: Hg, polychlorinated biphenyls (PCBs), and perfluoroalkyl substances (PFASs) were measured in maternal and children’s blood at 5 years (n = 449 and 419). At 7 years, children were administered Boston Naming Test (BNT) and the Strengths and Difficulties Questionnaire (SDQ). We used the G-formula combined with SuperLearner to estimate independent and joint effects of chemicals at both ages. We constructed flexible exposure-response relationships and assessed interactions. Results: Most chemicals showed negative relationships with BNT scores. An interquartile range (IQR) increase in maternal Hg and perfluorooctanoic acid (PFOA) was associated with 0.15 standard deviation (SD) (95% confidence interval [CI] = –0.29, –0.03) and 0.14 SD (95% CI = –0.26, –0.05) lower scores in BNT, whereas a joint IQR increase in the mixture of chemicals was associated with 0.48 SD (95% CI = –0.69, –0.25) lower scores in BNT. An IQR increase in PFOA was associated with 0.11 SD (95% CI = 0.02, 0.26) higher total SDQ difficulties scores. Maternal ∑ PCBs concentrations were associated with lower SDQ scores ( β = –0.09 SD; 95% CI = –0.19, 0), whereas 5 years ∑ PCBs showed a negative association ( β = –0.09 SD; 95% CI = –0.21, 0). Finally, a joint IQR increase in the mixture was associated with 0.22 SD (95% CI = 0.04, 0.4) higher SDQ scores. Conclusions: Using a novel statistical approach, we confirmed associations between prenatal mercury exposure and lower cognitive function. The potential developmental effects of PFASs need additional attention.
The Actions of Sevoﬂurane and Desﬂurane on the (cid:1) -Aminobutyric Acid Receptor Type A Effects of TM2 Mutations in the (cid:1) and (cid:2) Subunits

Background: Previous studies have shown that speciﬁc amino acid residues in the putative second transmembrane segment (TM2) of the (cid:1) -aminobutyric acid receptor type A (GABA A ) receptor play a critical role in the enhancement of GABA A receptor function by halothane, enﬂurane, and isoﬂu- rane. However, very little is known about the actions of sevoﬂurane and desﬂurane on recombinant GABA A receptors. The aim of this study was to examine the effects of sevoﬂurane and desﬂurane on potentiation of GABA-induced responses in the wild-type GABA A receptor and in receptors mutated in TM2 of the (cid:2) 1, (cid:2) 2, or (cid:3) 2 subunits. Methods: GABA A receptor (cid:2) 1 or (cid:2) 2, (cid:3) 2 or (cid:3) 3, and (cid:1) 2s subunit cDNAs were expressed for pharmacologic study by transfection of human embryonic kidney 293 cells and assayed using the whole cell voltage clamp technique. Concentration–response curves and EC 50 values for agonist were determined in the wild-type (cid:2) 1 (cid:3) 2 (cid:1) 2s and (cid:2) 2 (cid:3) 3 (cid:1) 2s receptors, and in receptors harboring mutations in TM2, such as (cid:2) 1(S270W) (cid:3) 2 (cid:1) 2s, (cid:2) 1 (cid:3) 2(N265W) (cid:1) 2s, and (cid:2) 2(S270I) (cid:3) 3 (cid:1) 2s. The actions of clinically relevant concentration of volatile anesthetics (isoﬂurane, sevoﬂurane, and desﬂurane) on GABA activated Cl (cid:4) currents were compared in the wild-type and mutant GABA A receptors. Results: Both sevoﬂurane and desﬂurane potentiated submaximal GABA currents in the wild-type GABA A (cid:2) 1 (cid:3) 2 (cid:1) 2s receptor and (cid:2) 2 (cid:3) 3 (cid:1) 2s receptor. Substitution of Ser270 in TM2 of the (cid:2) subunit by a larger amino acid, tryptophan (W) or isoleucine (I), as in (cid:2) 1(S270W) (cid:3) 2 (cid:1) 2s and (cid:2) 2(S270I) (cid:3) 3 (cid:1) 2s, completely abolished the potentiation of GABA-induced currents by these anesthetic agents. In contrast, mutation of Asn265 in TM2 of the (cid:3) subunit to tryptophan (W) did not prevent potentiation of GABA-induced responses. The actions of sevoﬂurane and desﬂurane in the wild- type receptor and in mutated receptors were qualitatively and quantitatively similar to those observed for isoﬂurane. Conclusions: Positions Ser270 of the GABA A (cid:2) 1 and (cid:2) 2 subunits, but not Asn265 in the TM2 of the (cid:3) 2 subunit, are critical for regulation of the GABA A receptor by sevoﬂurane and des- ﬂurane, as well as isoﬂurane, consistent with the idea that these three volatile anesthetics share a common site of actions on the (cid:2) subunit of the GABA A receptor.
Hepatitis C Virus and B-cell non-Hodgkin Lymphomas: An Italian multi-centre case-control study

Background: The existence of an association between infection with hepatitis C virus (HCV) and B-cell non-Hodgkin Lymphoma (B-NHL) remains controversial, largely because previous studies were based on prevalent case-series or comparisons with less than optimal control groups. Objective: To evaluate the association between HCV infection and B-NHL of different type. Design: Hospital-based case-control study. Patients and Methods: The study was conducted from January 1998 through February 2001. The cases consisted of consecutive patients with a new diagnosis of B-NHL; the controls were patients from other departments of the same hospitals. Both groups were interviewed using a standardised questionnaire. The prevalence of HCV infection was calculated by histological type of B-NHL and clinical behaviour (indolent or aggressive). Adjusted odds ratios (OR) and HCV-attributable risk (AR) were estimated. Results: The HCV prevalence was 17.5% among the 400 lymphoma cases and 5.6% among the 396 controls. The OR of B-NHL (cases vs. controls), adjusted by age, sex, level of education and place of birth, was 3.1 (95% Confidence Interval, C.I. 1.8-5.2); an OR indicative of positive association was found for both indolent and aggressive B-NHL. The estimated AR was 4.6%. Conclusions: This study confirms an association between HCV and B-NHL. In Italy one out of 20 of B-NHL may be attributable to HCV infection and may, thus, benefit of anti-viral treatment. Our findings suggest that Italy about one out of 20 B-NHL cases may be attributable to HCV and point to some important new treatment options for such patients. Interferon (IFN), in combination with ribavirin, has been shown to be effective in 50% of patients with chronic HCV-related liver diseases and to induce regression of splenic lymphomas in HCV-RNA positive patients large randomised clinical trials evaluate efficacy of IFN ribavirin HCV-infected all B-NHL
The Predictive Value of On-treatment Virological Response for Sustained Virological Response in C h r o n i c H e p a i i s Personalized Treatment Program

Objective To investigate the effects of individualised treatment with peginterferon alpha-2a (40 kD) plus ribavirin in Chinese patients with CHC. Methods Total of 297 consecutive Chinese patients were enrolled, including 250 naïve cases and 47 cases who were previously treated. Treatment duration was determined according to viral genotypes, prior treatment history and viral responses at week 4, 12 and 24. Results Totally, 235 patients (79.1%) completed treatment and 186 (87.3%) achieved SVR. And 219 out of 289 (75.8%) patients achieved HCV RNA negative at week 4 (RVR) and 259 of 276 (93.8%) at week 12. Among the 164 patients with RVR who completed follow-up, 158 (96.3%) achieved SVR. Patients with RVR had lower baseline viral loads than patients without RVR ( P = 0.034). The positive predictive value (PPV) of RVR for SVR was 90.7% (OR 2.10 vs. non-RVR, 95% CI: 0.50 - 8.7). Similar outcomes were observed among patients with HCV undetectable at week 12. Conclusions Complete viral suppression by week 4 is associated with a high rate of treatment success in treatment naïve and experienced patients receiving individualized CHC therapy. or 180 mg/week (83.3%), or conventional interferon (84.6%). Patients had undetectable HCV RNA at week 12 with no statistically significant difference between patients assigned to peginterferon alfa-2a at a dosage of 135 mg/week (95.0%) or 180 mg/week (92.0%), or conventional interferon (94.4%).