Miracle-dz/UniFAR-FTUs huggingface dataset:
Recovery of Warm Ischemic Rat Liver Grafts by Normothermic Extracorporeal Perfusion

Liver transplantation is currently the only established treatment of end-stage liver disease, but it is limited by a severe shortage of viable donor livers. Donors after cardiac death (DCD) are an untapped source that could significantly increase the pool of available livers. Preservation of these DCD livers by conventional static cold storage (SCS) is associated with an unacceptable risk of primary nonfunction and delayed graft failure. Normothermic extracorporeal liver perfusion (NELP) has been suggested as an improvement over SCS. Livers recovered from male Lewis rats were subjected to 1 hr of warm ischemia and preserved with 5 hr of SCS or NELP, and transplanted into syngeneic recipients. As additional controls, non-ischemic livers preserved with 6 hr of SCS or NELP and unpreserved ischemic livers were transplanted. After NELP, ischemically damaged livers could be orthotopically transplanted into syngeneic recipients with 92% survival (n=13) after 4 weeks, which was comparable with control animals that received healthy livers preserved by SCS (n=9) or NELP (n=11) for 6 hr. On the other hand, animals from ischemia/SCS control group all died within 12 hr postoperatively (n=6). Similarly, animals that received ischemic livers without preservation all died within 24 hr after transplantation (n=6). These results suggest that NELP has the potential to reclaim warm ischemic livers that would not be transplantable otherwise. The rat model in this study is a useful platform to further optimize NELP as a method of recovery and preservation of DCD livers.
European consensus statement on leptospirosis in dogs and cats

areas of Europe, whereas so far, there are fewer reports of LPHS from North America (Schweighauser and Francey 2008a, Kohn et al. 2010, Sykes et al. 2011, Tangeman and Littman 2013). In September 2012, an expert panel was gathered by the International Society of Companion Animal Infectious Diseases (ISCAID) to discuss important aspects of canine leptospirosis in Europe and to develop a peer-reviewed, European consensus statement for practitioners. The aim of this consensus statement was to raise the awareness about leptospirosis and to outline the current knowledge on the epidemiology, clinical features, diagnostic tools, prevention and treatment measures relevant to canine and feline leptospirosis in Europe.
Collisional transport in non-neutral plasmas

Several recent experiments have measured collisional transport in non-neutral plasmas (heat conduction, test particle diffusion, and viscosity) that is from 10 to 104 times larger than predicted by classical theory. New guiding center theories of collisional transport have been developed that agree with the measurements. The experiments operate in the guiding center regime rc≪λD, where rc is the cyclotron radius and λD is the Debye length. In this regime, classical transport theory is irrelevant because it implicitly assumes the opposite ordering, λD≪rc, although this ordering is not always satisfied in neutral plasmas.
Enterococcus faecium isolated from Lombo, a Portuguese traditional meat product: characterisation of antibacterial compounds and factors affecting bacteriocin production.

Strain ST211CH, identified as a strain of Enterococcus faecium, isolated from Lombo produced a bacteriocin that inhibited the growth of Enterococcus spp. , Listeria spp. , Klebsiella spp. , Lactobacillus spp. , Pseudomonas spp. , Staphylococcus spp. and Streptococcus spp. The mode of action of the bacteriocin named as bacteriocin ST211Ch was bactericidal against Enterococcus faecalis ATCC19443. As determined by Tricine-SDS-PAGE, the approximate molecular mass of the bacteriocin was 8.0 kDa. Loss in antimicrobial activity was recorded after treatment with proteolytic enzymes. Maximum activity of bacteriocin ST211Ch was measured in broth cultures of E. faecium strain ST211Ch after 24 h; thereafter, the activity was reduced. Bacteriocin ST211Ch remained active after exposure to various temperatures and pHs, as well as to Triton X-100, Tween-80, Tween-20, sodium dodecyl sulfate, NaCl, urea and EDTA. Effect of media components on production of bacteriocin ST211Ch was also studied. On the basis of PCR reactions targeting different bacteriocin genes, i.e. enterocins, curvacins and sakacins, no evidences for the presence of these genes in the total DNA of E. faecium strain ST211Ch was obtained. The bacterium most probably produced a bacteriocin different from those mentioned above. Based on the antimicrobial spectrum, stability and mode of action of bacteriocin ST211CH, E. faecium strain ST211Ch might be considered as a potential candidate with beneficial properties for use in biopreservation to control food spoilage bacteria.
Mathematical Modeling of Glucose Regulation System in Term of Perturbed Coefficients

In this research a recent developed practical modeling technique is applied for the glucose regulation system identification. By using this technique a set of mathematical models is obtained instead of single one to compensate for the loss of information caused by the optimization technique in curve fitting algorithms, the diversity of members inside the single set is interpreted in term of restricted range of its parameters, also a diagnosis criteria is developed for detecting any disorder in the glucose regulation system by investigating the influence of variation of the parameters on the response of the system, this technique is applied in this research practically for 20 cases with association of National Center for Diabetes / Al Mustanseryia University.
Study on Topology of the Set of Equilibrium Points of Longitudinal Dynamics of Hypersonic Vehicles

This paper describes the topology of equilibrium points of longitudinal dynamics of hypersonic vehicles using numerical analysis method based on the model developed by Bolender and Doman. First, the set of equilibrium points of longitudinal dynamics in cruise condition is obtained under reasonable flight constraint and flight envelope expressed by flight velocity and altitude is approximately estimated. Second, the relationships of the angle of attack, elevator deflection and equivalence ratio to velocity and altitude are studied and three block diagrams for the three relationships are plotted respectively.
The Assessment of Social Skills Deficits in the Elderly

This paper tested the hypothesis that a sample of elderly people compared to a matched sample of younger people reports an increase in difficulty and social anxiety in dealing with a wide range of everyday social situations. The literature on assertiveness and social skills training with the elderly was first reviewed. Then an assertiveness and social difficulty scale was administered to a group of eighty participants divided by age and sex. It was found that older people experienced less discomfort in situations requiring assertiveness, yet were less likely to respond assertively. Older people reported higher incidence of social anxiety across forty everyday situations. In general females reported more difficulty than males, though there were no interaction effects. The results are discussed in terms of the assessment and training of social skills in the elderly.
AB-OSEM reconstruction for improved kinetic parameter estimation

The non-negativity constraint inherently present in OSEM reconstruction successfully reduces the standard deviation in cold regions but at the cost of introducing a positive bias especially at low iteration numbers. For low count data, as often encountered in the short duration frames in dynamic imaging protocols, it has been shown that it can be advantageous (in terms of bias in the reconstructed image) to remove the non-negativity constraint. In this work two competing algorithms that do not impose non-negativity in the reconstructed image are investigated: NEG-ML and AB-OSEM. It was found that the AB-OSEM reconstruction outperformed the NEG-ML reconstruction. The AB-OSEM algorithm was then further developed to allow a forward model that includes randoms and scatter background terms. In addition to static reconstruction the current analysis was extended to consider the important case of kinetic parameter estimation from dynamic PET data. Simulation studies (comparing OSEM, FBP and AB-OSEM) showed that the positive bias obtained with OSEM reconstruction can be avoided in both static and parametric imaging through use of a negative lower bound in AB-OSEM reconstruction (i.e. by lifting the implicit non-negativity constraint of OSEM). When quantification tasks are considered, the overall error in the estimates (composed of both bias and standard deviation) is often of primary concern. An important finding of this work is that in most cases the activity concentration and the kinetic parameters obtained from images reconstructed using AB-OSEM showed a lower overall root mean squared error (RMSE) compared to the popular choices of either OSEM or FBP reconstruction for both cold and warm regions. As such, ABOSEM should be preferred instead of the standard OSEM and FBP reconstructions when kinetic parameter estimation is considered. Finally, this work shows example parametric images from the high resolution research tomograph (HRRT) obtained using the different reconstruction methods.
MMP-2 but not MMP-9 associated with COX-2 and survival in gastric cancer

Background and aim: Matrix metalloproteinases (MMPs) MMP-2 and MMP-9 can degrade type IV collagen of extracellular matrix and basal membranes. As cyclo-oxygenase-2 (COX-2) has been shown to activate MMPs, creating one of the COX-2-promoted pathways of tumour growth and metastasis, the prognostic role of MMP-2 and MMP-9 in gastric cancer was assessed and their association with COX-2 expression was evaluated. Materials and methods: Samples were collected from 342 consecutive patients operated on for gastric cancer, of which 315 were acceptable for MMP-2, MMP-9 and COX-2 immunohistochemistry. Specimens were stained with specific antibodies, evaluated and categorised by two interpreters, and then correlated with clinical data and survival. Results: Epithelial MMP-2 immunoreactivity was associated with male sex, high stage, advanced penetration depth, non-curative surgery, high COX-2 expression and poor survival. Stromal MMP-2 expression correlated with high stage, intestinal type and non-curative surgery whereas MMP-9 correlated only with intestinal type. Stage, intent of surgery and COX-2 were independent prognostic factors. Conclusions: Epithelial MMP-2 expression in gastric cancer is associated with aggressive forms, COX-2 and poor survival, although MMP-2 was not an independent prognostic factor. In gastric cancer tumour growth is apparently induced by COX-2, and invasion is mediated by MMP-2.
Schema Matching using Machine Learning Author Identity hidden due to Anonymous Submission

Schema Matching is a method of finding attributes that are either similar to each other linguistically or represent the same information. In this project, we take a hybrid approach at solving this problem by making use of both the provided data and the schema name to perform one to one schema matching and introduce creation of a global dictionary to achieve one to many schema matching. We experiment with two methods of one to one matching and compare both based on their F-scores, precision and recall. We also compare our method with the ones previously suggested and highlight differences between them. Keywords—Schema Matching, Machine Learning, SOM, Edit Distance, One to Many Matching, One to One Matching
Extraction of Harmonics Using Composite Observers

Online extraction of individual harmonics from repetitive signals using a composite asymptotic observer is presented in this paper. The settling period and the bandwidth of the observer depend on how far the observer poles have been placed from the origin of the s-plane or the z-plane. The errors in the magnitude and phase of the extracted components, due to the deviation of the signal from the central frequency of the observer, are made very small by providing an integrated phase-locking arrangement. Further improvement in the accuracy, particularly in the extracted higher harmonics, is due to the introduction of multirate sampling.
A preliminary analysis of domain coupling in package power distribution network

The coupling of power domains in a typical package power distribution network (PDN) is investigated, mainly focusing on the effect of ground structures and substrate parameters. From the simulated impedance parameter data, the self and the coupling capacitances are calculated. The preliminary study shows that the effect of the bottom ground planes has the most dominant effect on the domain coupling, and the ground plane between adjacent power domains can be effectively used to reduce the domain coupling.
Generation of form's input elements select and radio type using web service

The contribution deals with proposal and realization of web service assigned for generation of form's input elements select and radio type. In introduction it offers short survey of actual frameworks with similar possibilities and determinates suggested web service in regard to some frameworks' disadvantages. The web service allows creation of elements <;select> and <;input type="radio"> based on defined database table columns. In next part paper specifies web service purpose and solution principle, its structure and particular methods, more detailed describes all the input parameters of web service as well as service's error states that can arise in consequence of not entered or misdefined input parameters of service. The last part of contribution is devoted to client's side solution as well as service's utilization that it illustrates with specific example.
The use of enrichment serology for Salmonella detection in human foods and animal feeds.

Summary. Samples (2208) of food raw materials and products were examined for the presence of salmonellae by use of conventional salmonella detection procedures and the enrichment serology (ES) techniques described by Sperber & Deibel (1969); 348 samples were positive for salmonellae by the conventional procedures. Using the ES technique with a 24 h elective enrichment step, 93–98% of samples positive by the conventional procedures were also positive by the ES technique. Selective enrichment of food samples using tetrathionate broth containing novobiocin, incubated at 41°, led to the best recovery of salmonellae by both the conventional and ES techniques.
An adult patient with severe hypercalcaemia and hypocalciuria due to a novel homozygous inactivating mutation of calcium‐sensing receptor

Inactivating mutations in the calcium‐sensing receptor (CaSR) cause familial hypocalciuric hypercalcaemia (FHH) and neonatal severe hyperparathyroidism (NSHPT). Earlier investigations showed patients with FHH are heterozygous, and NSHPT are homozygous for inactivating mutations. However, one adult patient with severe hypercalcaemia and hypocalciuria has been reported to have a homozygous inactivating mutation in CaSR (Pro39Ala). This suggested that mutant CaSR in this patient had some residual activity and hypercalcaemia was not so severe as to be fatal. However, the function of this mutant CaSR was not evaluated. In the present study, we describe a novel homozygous mutation in an adult patient with severe hypercalcaemia and hypocalciuria, and evaluate the function of the mutant CaSRs. The DNA sequence of CaSR gene was determined by direct sequencing of the polymerase chain reaction product. The function of mutant CaSR was analysed by creating mutant cDNAs by in vitro mutagenesis, transfection of mutant cDNAs into HEK293 cells and measuring intracellular ionized Ca in response to changes in extracellular Ca. A 26‐year‐old Japanese woman showed marked hypercalcaemia with an elevated parathyroid hormone (PTH) level. Her consanguineous parents had asymptomatic hypercalcaemia with relative hypocalciuria. The proband had a homozygous mutation at codon 27 of CaSR gene (CAA→CGA, Gln27Arg). Her parents were heterozygous for this mutation. EC50 for Ca of this mutant CaSR (Gln27Arg) was 4.9 m m. EC50 of another mutant CaSR (Pro39Ala) whose homozygous mutation was discovered in an adult patient was 4.4 m m. These EC50s were significantly higher than that of wild‐type CaSR (3.7 } 0.1 m m), but were the lowest among the reported EC50s for inactivating mutations of CaSR. These results indicate that serum Ca and PTH levels are determined by residual function of mutant CaSR in patients with homozygous mutation in CaSR, and that patients having homozygous mutant CaSRs with mild dysfunction do not suffer from fatal hypercalcaemia in infancy and can survive into adulthood.
Optimal derivative filters with well-distributed based image mosaic algorithm

An automatic image mosaic method based on the optimal derivative filters with well-distributed was proposed. Firstly interest points in an image are detected by Harris operator with optimal derivative filters, delaunay triangulation is used to reject the spurious feature points pair and estimate the parameters of geometric transform model. After the geometric transform of input images, the two images were fused and the image stitching was finished. The experimental results show that the proposed algorithm produces an improvement in mosaic accuracy, efficiency and robustness.
An update on the approach to apparent life-threatening events

Purpose of review Apparent life-threatening events are an ongoing diagnostic dilemma for clinicians. Since most apparent life-threatening event episodes occur in infants under 6 months of age, they can generate considerable anxiety in parents and providers. This review will discuss issues to consider in the evaluation of infants after an apparent life-threatening event. To ensure proper management, a systematic approach should be taken to attempt to determine the cause of the event. Recent findings More recent literature suggests that infants with apparent life-threatening events frequently present without signs or symptoms of illness. Obtaining a careful history and physical examination is essential in determining the cause of the event. In this article, we will review the most current literature and discuss the American Academy of Pediatrics new recommendations on sudden infant death syndrome prevention. Summary After a careful review of the literature, prone sleeping is one of the biggest risk factors for sudden infant death syndrome. The association between apparent life-threatening events and sudden infant death syndrome remains to be explored further, but current evidence suggests minimal risk after an apparent life-threatening event episode. This article will help clinicians prepare for this difficult challenge by providing up-to-date information and identifying problems to be addressed in future research.
Inhibition of Protein Synthesis in Apoptosis : Differential Requirements by the Tumor Necrosis Factor Family and a DNA-damaging Agent for Caspases and the Double-stranded RNA-dependent Protein Kinase 1

Exposure of mammalian cells to agents that induce apoptosis results in a rapid and substantial inhibition of protein synthesis. In MCF-7 breast cancer cells, tumor necrosis factor (TNF ) and TNF-related apoptosisinducing ligand inhibit overall translation by a mechanism that requires caspase (but not necessarily caspase-3) activity. This inhibition is associated with the increased phosphorylation of eukaryotic initiation factor (eIF2) , increased association of eIF4E with the inhibitory eIF4E-binding protein (4E-BP1), and specific cleavages of eIF4B and eIF2 . All of these changes require caspase activity. The cleavage of eIF4GI, which specifically needs caspase-3 activity, is dispensable for the inhibition of translation in MCF-7 cells. Similar experiments with embryonic fibroblasts from control mice and animals defective for expression of the double-stranded RNA-regulated protein kinase (PKR) reveal requirements for both caspase activity and PKR for inhibition of protein synthesis in response to TNF . In contrast, treatment of cells with the DNA-damaging agent etoposide inhibits protein synthesis equally well in the presence of a pan-specific caspase inhibitor and in the presence or absence of PKR. Surprisingly, the ability of etoposide to cause increased association of eIF4E with 4E-BP1 does require PKR activity. However, our data suggest that neither increased phosphorylation of eIF2 nor increased [eIF4E.4EBP1] complex formation is essential for the inhibition of overall translation by the DNA-damaging agent.
Direct assessment of functional status in older patients with schizophrenia.

OBJECTIVE There has been a growing trend in medicine to evaluate the impact of illness on functional abilities. Such studies typically rely on the patient's or caregiver's report. The goal of this study was to assess directly the functional capacity of psychiatric patients, especially older ones. METHOD The subjects were 55 outpatients with schizophrenia and 72 normal persons ranging in age from 45 to 86 years. The subjects were administered the Direct Assessment of Functional Status Scale, which assess behaviour during simulated daily activity tasks in the areas of time orientation, communication, transportation, finance, shopping, grooming, and eating. RESULTS The patients with schizophrenia had significantly greater disability than the normal subjects according to total scale scores as well as the communication, transportation, finance, and shopping subscale scores. Global cognitive status was the best predictor of total scale score. CONCLUSIONS The Direct Assessment of Functional Status Scale is a promising instrument for functional assessment in outpatients with schizophrenia.
A review of tensor‐based methods and their application to hospital care data

In many situations, a researcher is interested in the analysis of the scores of a set of observation units on a set of variables. However, in medicine, it is very frequent that the information is replicated at different occasions. The occasions can be time‐varying or refer to different conditions. In such cases, the data can be stored in a 3‐way array or tensor. The Candecomp/Parafac and Tucker3 methods represent the most common methods for analyzing 3‐way tensors. In this work, a review of these methods is provided, and then this class of methods is applied to a 3‐way data set concerning hospital care data for a hospital in Rome (Italy) during 15 years distinguished in 3 groups of consecutive years (1892–1896, 1940–1944, 1968–1972). The analysis reveals some peculiar aspects about the use of health services and its evolution along the time.
Insights into β2‐adrenergic receptor binding from structures of the N‐terminal lobe of ARRDC3

ARRDC3 is one of six known human α‐arrestins, and has been implicated in the downregulation of the β2‐adrenergic receptor (β2AR). ARRDC3 consists of a two‐lobed arrestin fold and a C‐terminal tail containing two PPYX motifs. In the current model for receptor downregulation by ARRDC3, the arrestin fold portion is thought to bind the receptor, while the PPXY motifs recruit ubiquitin ligases of the NEDD4 family. Here we report the crystal structures of the N‐terminal lobe of human ARRDC3 in two conformations, at 1.73 and 2.8 Å resolution, respectively. The structures reveal a large electropositive region that is capable of binding phosphate ions of crystallization. Residues within the basic patch were shown to be important for binding to β2AR, similar to the situation with β‐arrestins. This highlights potential parallels in receptor recognition between α‐ and β‐arrestins.