Miracle-dz/UniFAR-FTUs huggingface dataset:
Ru–η6-benzene–phosphine complex-catalyzed transfer hydrogenation of ketones

Three Ru–η6-benzene–phosphine complexes bearing tri-(p-methoxyphenyl)phosphine, triphenylphosphine and tri-(p-trifluoromethylphenyl)phosphine were synthesized and characterized by 31P{1H} NMR, 1H NMR, 13C{1H} NMR and elemental analyses. Complex 1 was further identified by X-ray crystallography. These complexes exhibit good to excellent activities for the transfer hydrogenation of ketones in refluxing 2-propanol, and the highest turnover frequency (TOF) is up to 5940 h−1. The effect of electronic factors of these complexes on the transfer hydrogenation of ketones reveals that the catalytic activity is promoted by electron-donating phosphine and the catalyst stability is improved by electron-withdrawing phosphine. Copyright © 2011 John Wiley & Sons, Ltd.
Tumor lysis syndrome in chronic lymphocytic leukemia: conventional treatment versus novel agents

Abstract Introduction: Existing evidence on the difference in the incidence of tumor lysis syndrome (TLS) in Chronic Lymphocytic Leukemia (CLL) patients receiving novel therapies versus patients receiving conventional therapies is limited and inconclusive. The aims of this planned systematic review and meta-analysis are therefore(1) assess the TLS incidence reported in clinical trials for the novel or targeted agents comparing to conventional chemotherapeutic agents used to treat patients with CLL(2) to identify the TLS prophylaxis strategies that are utilized in clinical trials of the novel or targeted agents for CLL if it was fully reported or under-reported and(3) to compare the mortality among patients with TLS in conventional versus novel agents. Methods: We will conduct a systematic review and meta-analysis. Several electronic databases will be searched using predefined search terms to identify relevant studies. Eligible studies should report findings on the incidence of TLS in CLL patients. Primary observational studies with cross-sectional or prospective research design, case-control studies, and studies with experimental designs will be included. Study quality will be evaluated by 2 reviewers using the statistical methodology and categories described in the Cochrane Collaboration Handbook and preferred reporting items for systematic reviews and meta-analyses and other applicable guidelines. The meta-analysis will be performed and conducted using applicable standard statistical software like comprehensive meta-analysis and STATA. Discussion: This review and meta-analysis will be among the first to systematically explore and integrate the evidence available on the comparison between the incidences of TLS in CLL patients treated with novel agents versus conventional agents. By gathering and summarizing information about the risk of TLS in this patient population, the findings from this review will provide insights for future research directions and more understanding of the difference of TLS incidence between novel treatments and conventional treatment and suggest prophylactic measures for such cases. Systematic review registration: The protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42020166770). The protocol was registered with the Hamad medical corporation, Medical research Center registry under a unique reference number (MRC-01-20-709).
The Development and Evaluation of an Emission Factor for a Toluene Parts-Washing Process

Field studies were performed to develop and evaluate emission factors for a parts-washing operation using toluene. Ventilation, process, and air concentration data were collected first for the development of an emission factor, then later for evaluation studies. Air concentrations and ventilation rates were used in mass balance models to determine emission rates. The average emission rate was 5.4 grams toluene per minute. The modeled emission rates compared favorably with estimates of toluene use. Emission and process rates were used to develop emission factors. The emission factor for parts washing was 1.6 mg toluene per square centimeter of part washed (r2=0.41, p <0.05). To evaluate this emission factor, process data and ventilation measurements were collected 6 months later to predict air concentrations. Predicted concentrations near the source ranged from 0 to 320 mg/m3, and for the rest of the plant from 0 to 2.8 mg/m3. Concentration measurements were taken but were not available until after the pre.
The prediction of metal-to-metal bonding in transition metal binary and related compounds

The evidence for, and the factors determining, the formation of metal-to-metal (m-m) bonds in transition metal oxides, sulphides, halides, and related complexes are discussed. It is proposed that when metals of high preferred valence state are constrained to low formal oxidation states, m-m bonds will form to allow the metal to exercise a higher valency. It is assumed that (n-l)d orbitals are used for such bonds and predictions of the feasibility of m-m bonding are possible by the comparison of the size of such orbitals with the expected inter-metal distances in polymeric metal oxides and halides. It is concluded that binary oxides and halides (excepting fluorides) of the lower oxidation states of Zr, Hf, Nb, Ta, Mo, W, and Re and of a few neighbouring elements will display m-m bonds.
A micro-macro relationship for modeling the damage of discontinuous reinforced composites

In discontinuous reinforced composites, different damage processes are observed: reinforcement fracture, interface debonding and matrix failure depending on the type of material and loading. So, local criteria of damage initiation were introduced in a micromechanical model to reproduce these phenomena and predict the material behavior. The model is based on the stiffness prediction by the Mori and Tanaka approach. Tensile stress-strain curves until total failure are simulated in the case of SMC type composite. The evolution with damage of all the elastic constants is also compared with ultrasonic measurements. In an Al/SiCp composite, damage was identified to be particle fracture. Tensile behaviors with or without damage are compaerd. Three solutions to replace the brown particles are studies
Relationship between long non-coding RNA and prognosis of patients with coronary heart disease after percutaneous coronary intervention

Abstract Background: Long non-coding RNA (lncRNA) can predict the prognosis of patients with coronary heart disease (CHD) after obtaining percutaneous coronary intervention (PCI), while this conclusion still needs to be further confirmed. Therefore, this study attempted to explore the relationship between lncRNA and prognosis in CHD patients after PCI. Methods: The database was retrieved from China National Knowledge Infrastructure (CNKI), Chinese Biomedical literature Database (CBM), Chinese Scientific and Journal Database (VIP), Wan Fang database, PubMed, and EMBASE. Hazard ratios (HRs) and its 95% confidence interval (CIs) were applied to assess the prognostic effects of lncRNA on overall survival (OS). RevMan 5.3 and STATA 16.0 software were used to perform meta-analysis. Results: The results of this meta-analysis would be submitted to peer-reviewed journals for publication. Conclusion: This review provided a comprehensive overview of the relationship between lncRNA and prognosis in CHD patients after PCI, and offered recommendations for clinical practices or guidelines.
In‐line Comparison of Particle Sizing by Static Light Scattering, Time‐of‐Transition, and Dynamic Image Analysis

Particle size analysis is important in both process and quality control. Different techniques are currently available. In this contribution, the characteristics of three techniques, based on Static Light Scattering (SLS), Time‐of‐Transition (TOT), and Dynamic Image Analysis (DIA), are compared using various aqueous dispersions. Hereby, the techniques were connected in series, so that simultaneous measurements could be performed on the same sample. The experimental results demonstrated that each of the investigated techniques has its strengths and limitations. Thus, SLS results may be largely affected by the choice of the refractive index of the dispersed particles as well as by the choice of the inversion algorithm to convert the angular spectrum to a particle size distribution. As neither TOT or DIA require information concerning the (complex) refractive index of the particles and are based on the detection of individual particles, these techniques are claimed to be very useful for measuring particles in the micrometer size range, although the measurement can be heavily affected by the particle transparency and concentration. Furthermore, all the techniques appear more suited to discerning small particles within a population of large particles than to detecting large particles within a population of small particles. Finally, TOT is much less sensitive towards submicron particles, as compared to SLS. The latter technique does not only have a broader dynamic range, which extends down to the submicron range, but also produces reliable results at higher sample concentrations as compared to TOT and DIA.
Older Adult Volunteers in Intergenerational Programs in Educational Settings Across the Globe

ABSTRACT Intergenerational volunteerism is a global phenomenon that aids multiple generations. Considering the positive evidence of volunteering among older adults and their desire for engagement with children, it is important to explore older adult volunteers’ experiences in intergenerational programs with a specific focus on the cultural and social impacts of volunteering in educational settings. Using a phenomenological qualitative approach, 43 interviews with older adult volunteers (23 in South Korea (Korea) and 20 in the United States (US) in intergenerational programs were conducted. Participants were recruited from the Beautiful Story Grandma (BSG) in Korea and the Foster Grandparent Program (FGP) in the US in 2019. Three major themes emerged from the interviews revolving around the role of culture and other demographics in the experience of volunteering: (1) Benefits from volunteering with children that transcend demographic and geographic differences; (2) distinctive cultural factors lead to different experiences of volunteering in educational settings; and (3) operational and procedural differences of volunteer programs impact older adult volunteers’ experiences in educational settings. This comparative research can inform the development of culturally responsive intergenerational volunteering programs for older adults and other generations in their communities.
Capillary electrophoresis for the determination of N-Acetyltyrosine and N-acetylcysteine in products for parenteral nutrition: Method development and comparison of two CE systems

Summary Because of the problems with stability and solubility, some of the amino acids (AAs) used in parenteral nutrition products are often replaced by their acetylated forms. These include N-acetyltyrosine (NAT) and N-acetylcysteine (NAC). This leads to a need to develop new analytical methods for rapid and easy determination of these substances in the presence of common AAs. Capillary electrophoresis (CE) is one of the techniques that have been successfully applied to the assay of multi-component samples containing AAs and their derivatives. This paper discusses a new CE method for the simultaneous determination of two acetylated AAs in solutions for parenteral nutrition. A background electrolyte (BGE) was developed based on borate buffer with alkaline pH. The method is selective and enables the separation and assay of analytes without special sample pretreatment. Validation parameters confirmed sufficient precision and accuracy of the method. Its applicability was verified by testing several medicinal.
Leucheria cantillanensis (Nassauvieae, Asteraceae), a new species endemic to Central Chile

Abstract A new species, Leucheria cantillanensissp. nov., endemic to the coastal mountain range of Central Chile, is described. By using both nDNA and cpDNA, phylogenetic relationships of the new species were investigated. This new species belongs to the acaulescent/subacaulescent clade of Leucheria, which is congruent with the morphology of the species. A detailed description, distribution map, insights about its habitat, conservation status, and illustrations are provided. An updated key for acaulescent/subacaulescent species of Leucheria from Central Chile is also given.
Study on the characteristics of TiAlN thin film deposited by atomic layer deposition method

The microstructural characteristics and electrical and chemical properties of TiAlN films deposited by the atomic layer deposition (ALD) method were investigated. The growth rate of TiAlN film was measured to be 1.67 A/cycle. TiAlN film deposited by ALD has a B1(NaCl) structure with a lattice parameter of 4.20 A. The chlorine content in TiAlN film was below the detection limit of Auger electron spectroscopy. TiAlN film showed the columnar structure with a resistivity of about 400 μΩ cm. The sheet resistance increased abruptly after annealing at 650 °C due to the formation of a high resistivity Cu-silicide phase at the interface between the TiAlN and Si substrate. The failure of the ALD TiAlN barrier layer was observed by an etch-pit test after annealing at 600 °C for 1 h. TiAlN films deposited by the ALD method exhibited excellent film properties and improved barrier characteristics compared to other chemical vapor deposition methods.
C-reactive protein for simple prediction of mortality in patients with acute non-variceal upper gastrointestinal bleeding

Supplemental Digital Content is available in the text Abstract In upper gastrointestinal bleeding (UGIB), scoring systems using multiple variables were developed to predict patient outcomes. We evaluated serum C-reactive protein (CRP) for simple prediction of patient mortality after acute non-variceal UGIB. The associated factors for 30-day mortality was investigated by regression analysis in patients with acute non-variceal UGIB (N = 1232). The area under the receiver operating characteristics (AUROC) curve was analyzed with serum CRP in these patients and a prospective cohort (N = 435). The discriminant validity of serum CRP was compared to other prognostic scoring systems by means of AUROC curve analysis. Serum CRP was significantly higher in the expired than survived patients (median, 4.53 vs 0.49; P < .001). The odds ratio of serum CRP was 4.18 (2.10–9.27) in multivariate analysis. The odds ratio of high serum CRP was higher than Rockall score (4.15 vs 1.29), AIMS65 (3.55 vs 1.71) and Glasgow-Blatchford score (4.32 vs 1.08) in multivariate analyses. The AUROC of serum CRP at bleeding was 0.78 for 30-day mortality (P < .001). In the validation set, serum CRP was also significantly higher in the expired than survived patients, of which AUROC was 0.73 (P < .001). In predicting 30-day mortality, the AUROC with serum CRP was not inferior to that of other scoring systems. Serum CRP at bleeding can be simply used to identify the patients with high mortality after acute non-variceal UGIB.
The Impact of microRNA Regulation on Immune Recovery in HIV-1-Infected Patients Treated during Acute Infection: A Pilot Study

microRNAs (miRNAs) are small noncoding RNAs involved in a large range of cellular activities and can be used as biomarkers and indicators for diagnosis. We investigated the alterations in miRNA profiles in immune reconstituted vs. nonimmune reconstituted HIV-1-infected individuals to assess the association between miRNAs and the occurrence of immunological nonresponses, with the aim of searching for miRNA-based biomarkers for these HIV-1-infected individuals. Thirteen immunological responders (IRs) and 12 immunological nonresponders (INRs) were recruited, and RNA was collected from the plasma samples of the 25 HIV-1-infected individuals at both baseline and after 24 months of maintaining virological suppression (VS). Next-generation sequencing was used to detect miRNAs and evaluate the expression differences in miRNAs between IR and INR patients and between baseline and after 24 months of maintaining VS. Samples from 13 IRs and 11 INRs were successfully sequenced. The horizontal comparison of differentially expressed miRNAs between the groups and the longitudinal comparison of differentially expressed miRNAs between baseline and after 24 months of maintaining VS showed that a large proportion of miRNAs in INRs are downregulated compared to the levels in IRs. We also found that the miRNA let-7d-5p was downregulated in 9 INRs but only in 2 IRs by more than 2-fold. The difference was significant. In summary, these results demonstrate for the first time that a large proportion of miRNAs are downregulated in INRs compared with IRs, and the miRNA let-7d-5p is a potential biomarker for INRs.
Prevalence of vitamin D status and its association with overweight or obesity in a population of Colombian children and adolescents

The present study aimed to estimate the prevalence of 25-OH-D status (insufficiency and deficiency) in children and adolescents residing in Bucaramanga, Colombia and to determine its association with excess weight. A case–control study was nested in the SIMBA II cohort in children and adolescents between the ages of 11 and 20 years old. Cases were defined as those children and adolescents with overweight or obesity. The control group was composed of children and adolescents from the same population sample with similar sociodemographic and economic characteristics but without overweight or obesity diagnosis. 25-hydroxyvitamin D (25-OH-D) was quantified in serum using a chemiluminescent microparticle immunoassay. Logistic regression models were used to assess the association between vitamin D status and overweight or obesity adjusted for the main confounding variables. A total of 494 children and adolescents cases were 138 (52⋅17% boys and 47⋅83% girls; median age 16⋅0 [Q1 15; Q3 18]). The median BMI S-Score minors age in the cases was 1⋅36 [Q1 1⋅06; Q3 2⋅00] and BMI (kg/m2) 28⋅0 [Q1 26⋅2; Q3 30⋅8]. The prevalence of vitamin D in the cases was deficiency 16⋅67%, insufficiency 57⋅25%, sufficiency 26⋅09. 25-OH-D insufficiency was associated with overweight or obesity after adjusting for the main confounding variables (OR 1⋅73; 95% CI 1⋅05–2⋅84). Our study concludes that the 25-OH-D insufficiency is common in children and adolescents in Bucaramanga, Colombia, and it was associated with overweight or obesity.
Implementing a psycho-educational model to increase university lecturers’ effectiveness to constructively manage experienced aggression

Background The authors developed a psycho-educational model as a conceptual framework of reference for university lecturers to facilitate the constructive management of experienced aggression. The model must be implemented in a workshop and in practice to confirm the if the model is effective. Aim This article describes the implementation of a psycho-educational model in a workshop and in practice, as well as the evaluation of the effectiveness of the psychoeducational model. Setting This study was conducted in a specific college at a university in Johannesburg in South Africa. Method This study followed a qualitative, exploratory, descriptive, contextual and theory-generating research design. The psycho-educational model was implemented in three phases during a workshop and then for three months in practice by university lecturers. A purposive sample of university lecturers was applied. The effectiveness of the psycho-educational model was evaluated during and directly after the workshop, 1 week after the workshop and 3 months journal entries. Final evaluation was in a focus group after 3 months of implementation of the model in the workplace. Results The participating university lecturers found the implementation of the psycho-educational model, as a conceptual framework of reference to constructively manage experiences of aggression, effective, helpful and important. The model increased their understanding of aggression in their places of work and increased their effectiveness to constructively manage experiences of aggression in their workplace. Conclusion The implementation and evaluation of the psycho-educational model underscored the need for affective and effective facilitative support for university lecturers to be able to constructively manage experienced aggression.
Characterization and optimization of an integrating sphere-based detector for the estimation of tissue optical properties

An integrating sphere system has been developed to non-invasively study the optical properties of biological tissues over a broad spectral range. Using the integrating sphere as both a diffuse illumination source and a detector provides a technically simple measurement apparatus with numerous advantages. A primary advantage is the reduction of the effect of spatial inhomogeneities on the determination of optical properties, afforded by the increased area of detection through the port-opening of the sphere, which challenges many fibre-based, spatially-resolved measurements. Through a single measurement of total diffuse reflectance, an estimation of the transport albedo of homogeneous, liquid phantoms can be made for those cases where scattering is greater than a determined threshold. Further estimations can be made to describe the absorption environment. The effects of the sphere geometry, particularly port-opening size, on the accuracy of the estimated optical properties will be discussed. These results will be used to modify the design of the integrating sphere as an efficient illuminator and light collector, in order to optimize its use in determining the optical properties of biological tissues.
Personality and Insomnia Symptoms in Older Adults: The Baltimore Longitudinal Study of Aging.

STUDY OBJECTIVE To examine associations of personality dimensions and facets with insomnia symptoms in a community sample of older adults. METHODS We studied 1,049 participants aged 60-97 years in the Baltimore Longitudinal Study of Aging. Personality was assessed by the Revised NEO Personality Inventory (NEO-PI-R), and insomnia symptom severity was measured by the Women's Health Initiative Insomnia Rating Scale (WHIIRS). RESULTS Adjusting for demographic characteristics, higher neuroticism, lower conscientiousness, and lower extraversion were associated with greater insomnia symptom severity. These associations remained significant for neuroticism and conscientiousness when further adjusting for depressive symptoms and comorbidities. Higher scores on neuroticism facets Anxiety, Angry Hostility, and Depression, and lower scores on conscientiousness facets Competence, Order, and Achievement-Striving and on agreeableness facet Altruism were associated with greater insomnia symptom severity in fully adjusted models. Results were similar among cognitively normal older adults (N=966), except higher scores on extraversion facets Warmth and Assertiveness associated with lower insomnia symptom severity, and agreeableness facet Altruism was unassociated. CONCLUSION Among older adults, insomnia symptoms appear partially related to personality, with persons higher in neuroticism experiencing greater insomnia symptom severity, and those higher in conscientiousness experiencing lower insomnia symptom severity. Exploring facets of the Big Five dimensions may provide additional insight regarding the etiology and resolution of sleep disturbance, and some of these associations may differ based on cognitive status. Future studies should investigate the hypothesis that sleep impairment mediates part of the association between specific personality traits and health-related outcomes.