Miracle-dz/UniFAR-FTUs huggingface dataset:
Detection of an intense resonance at 2.4 ppm in 1H MR spectra of patients with severe late‐delayed, radiation‐induced brain injuries

Proton MRS and MRI were used to monitor the progression of severe cerebral radiation injuries in 10 patients over a period of 18 months. An unknown resonance (Px) in the 2.37–2.40 ppm region was consistently detected in the affected temporal lobes of four patients. The detection of Px was only confined to spectra with lactate (Lac) and in patients with the highest severity grading of radiation injury. The incidence of Px in Lac‐positive spectra was 42.8% (15/35) and in lesions with highest injury grading was 46.8% (15/32). Lesions with Px had significantly higher Lac/creatine (Cr) ratios and more extensive mass effect changes when compared to lesions without Px. The probable identity of Px was examined in the context of anaerobic glycolysis producing pyruvate (2.37 ppm) and the model of metabolic changes in brain abscess formation implicating succinate (2.40 ppm). Magn Reson Med 45:994–1000, 2001. © 2001 Wiley‐Liss, Inc.
Analysis of noise reduction and dereverberation techniques based on microphone arrays with postfiltering

In teleconferencing systems, the use of hands-free sound pick-up reduces speech quality. This is due to ambient noise, acoustic echo, and the reverberation produced by the acoustical environment. This paper sets out to present a theoretical analysis of noise reduction and dereverberation algorithms based on a microphone array combined with a Wiener postfilter. It is shown that the transfer function of the postfilter depends on the input signal-to-noise ratio (SNR) and on the noise reduction yielded by the array. The use of a directivity-controlled array instead of a conventional beam-former is proposed to improve the performance of the whole system. Examples in real room environments are provided, which confirm the theoretical results, It is observed that the postfilter gives a limited reduction of the reverberation. On the contrary, an appreciable reduction of acoustic echo and localized noise is obtained and makes the whole system highly attractive for hands-free communication systems.
Robotics and Autonomous Systems Multi-agent systems : which research for which applications Eug 6

For sometime now agent-based and multi-agent systems (MASs) have attracted the interest of researchers far beyond traditional computer sciience and artificial intelligence (AI). In this article we try to identify focal points of interest for researchers working in 1:he area of distributed AI (DAI) and MAS as well as application-oriented researchers coming from related disciplines, e.g. electrical and mechanical engineering. We do this by presenting key research topics in DAI and MAS research and by identifying application domains in which the DAI and MAS technologies are most suitable. The research topics we discuss are separated into agent architectures and organisations, negotiation among agents, and self-adaptation of MAS using learning techniques. Regarding the application domains for these techniques we distinguish the application domains according to w]hether the agents control a physical or virtual body (Gestalt) or not. This separation of the application domains is not strict; it represents two ends of a continuum. On the one end of this continuum we have autonomous robot systems which act in a physical environment (sometimes referred to as hardware agents), and on the other end, we have abstract environments, such as in workflow systems, which rarely display the geometrical and physical aspects of the environment we are used to living in. © 1999 Elsevier Science B.V. All right reserved.
Carrier testing and prenatal diagnosis of haemophilia B by SSCP in an Iranian family

Summary. Haemophilia B is an X‐linked recessive bleeding disorder caused by multiple molecular defects in factor IX gene. During our genotyping programme of haemophilia B patients, a family from the west of Iran was referred to us. We first detected the mutation in the index case of the family by single‐strand conformation polymorphism (SSCP) technique. This technique was then applied in carrier detection and prenatal diagnosis for females of this family. Sequencing later revealed the mutation as being G to A at 20519.
Evolution of the Walvis Ridge-Rio Grande Rise Hot Spot System: Implications for African and South American Plate motions over plumes

Crystallization ages of volcanic rocks, dredged or drilled from the Walvis Ridge (ten sites) and the Rio Grande Rise (one site), have been determined by the 40Ar/39Ar incremental heating technique. The fundamentally age-progressive distribution of these basement ages suggests a common hot spot source for volcanism on the island of Tristan da Cunha, along the Walvis Ridge and Rio Grande Rise, and for the formation of the continental flood basalts located in Namibia (Africa) and Brazil (South America). The Walvis Ridge-Rio Grande Rise volcanic system evolved along a section of the South Atlantic spreading-axis, as the African and South American plates migrated apart, astride, or in close proximity to, an upwelling plume. Reconstructions of the spatial relationship between the spreading-axis, the Tristan hot spot, and the evolving Walvis Ridge-Rio Grande Rise volcanic feature show that, at about 70 Ma, the spreading-axis began to migrate westward, away from the hot spot. The resulting transition to intraplate hot spot volcanism along the Walvis Ridge (and associated termination of Rio Grande Rise formation) also involved a northward migration of previously formed African seafloor over the hot spot. Rotation parameters for African motion over fixed hot spots (i.e., absolute motion) have been recalculated such that the predicted trail of the Tristan hot spot agrees with the distribution of radiometric and fossil basement ages along the Walvis Ridge. African absolute motion has been extended to the South and North American plates, by the addition of relative motion reconstruction poles.
LPI KA-band radar sensor

Examples of such devices include navigational X-band radar "BR-24" by Lowrance and River radar from Mi-cran. By maximizing experience of the navigational radar River creation, its developers (authors of the paper) realize a model of millimeter-wave homodyne radar sensor with operation frequency of 33.8 GHz, radiated power 40 mW, LFM-CW sounding signal, beam width in the elevation plane 30 deg. and 1 deg. in the azimuth plane, horizontal size of the antenna aperture of 60 cm, velocity of at azimuth 144 grad/sec, maximum resolution at range ~ 0.5 m, radiated signal bandwidth 50-600 MHz, adjusted at the program level.
Induction of tubulin by docetaxel is associated with p53 status in human non small cell lung cancer cell lines

Docetaxel (DOC), a member of the taxane family of anticancer drugs, binds to tubulin and produces unnaturally stable microtubules that induce cell death. DOC is used clinically alone or in combination with other compounds to treat advanced stages of cancer. We have treated the human lung cancer cell lines A549 and H1299 and human cervical cancer HeLa cells with low concentrations of DOC to characterize the response of β‐tubulin isotypes and p53 genes. The relationship between p53 function and DOC, acting through a microtubule‐based mechanism, was examined. We found that after 18‐hr treatment with DOC, β‐tubulin gene transcription was enhanced in p53‐null H1299 cells but not in A549 cells. Also, p53 RNA was strongly induced in the A549 cells. In addition, β‐tubulin levels also increased in the H1299 cells after the DOC treatment. Further demonstrating an association of DOC treatment with p53 and β‐tubulin, inhibition of p53 expression by interference RNA in A549 cells showed increasing β‐tubulin gene expression with DOC treatment. We also selected a clone from the H1299 cells that stably expressed p53, examined the β‐tubulin expression after DOC treatment and found an inhibition of β‐tubulin induction in these p53‐expressing cells. Our data suggest that the initial response of cells to DOC treatment involves p53; alternatively, in the absence of p53, tubulins may be transactivated. Selection of the DOC‐resistant A549 cells showed β‐tubulin expression was increased, in contrast to the initial response to the DOC treatment. From the initial and selection responses of β‐tubulin in cancer cells, it appears that there is a p53‐associated β‐tubulin expression as a result of the DOC treatment. © 2005 Wiley‐Liss, Inc.
Urinary desmosine as a biomarker in acute lung injury

Abstract Acute lung injury (ALI) is a complex disorder associated with an acute inflammatory response thought to contribute to tissue injury. Desmosine, a cross-linking amino acid present in elastin, is released during matrix degradation and cleared by the kidney. Results from animal models and human disease studies have suggested that ALI is associated with the release of desmosine, resulting in increased urinary desmosine. A radioimmunoassay was used to monitor urinary desmosine levels over 10 days in ten patients with ALI. The concentration of desmosine was measured with and without acid hydrolysis. Baseline urinary desmosine was increased in two of ten patients. The concentration of desmosine at baseline did not appear to be related to age, gender, neutrophil elastase (NE)/α1-antiprotease complex concentration or PaO2/FiO2 ratio. No meaningful changes in desmosine levels were noted after removal from mechanical ventilation. Baseline desmosine concentrations did not appear to correlate with the risk of death. The limited sensitivity, predictive correlations and dynamic modulation would suggest that urine desmosine has a limited role as a biomarker for ALI. Hydrolysis of urine samples appears necessary for optimal measurement of urine desmosine.
Standardised criteria improve accuracy of ECG interpretation in competitive athletes: a randomised controlled trial

Background Screening to prevent sudden cardiac death remains a contentious topic in sport and exercise medicine. The aim of this study was to assess whether the use of a standardised criteria tool improves the accuracy of ECG interpretation by physicians screening athletes. Methods Design: Randomised control trial. Study population: General practitioners with an interest in sports medicine, sports physicians, sports medicine registrars and cardiologists from Australia and New Zealand were eligible to participate. Outcome measures: Accuracy, sensitivity, specificity and false-positive rates of screening ECG interpretation of athletes. Intervention: A two-page standardised ECG criteria tool was provided to intervention participants. Control participants undertook ‘usual’ interpretation. Results 62 physicians, with a mean duration of practice of 16 years, were randomised to intervention and control. 10 baseline and 30 postrandomisation athlete ECGs were interpreted by the participants. Intervention participants were more likely to be correct: OR 1.72 (95% CI 1.31 to 2.27, p<0.001). Correct ECG interpretation was higher in the intervention group, 88.4% (95% CI 85.7% to 91.2%), than in the control group, 82.2% (95% CI 78.8% to 85.5%; p=0.005). Sensitivity was 95% in the intervention group and 92% in the control group (p=0.4), with specificity of 86% and 78%, respectively (p=0.006). There were 36% fewer false positives in the intervention group (p=0.006). Conclusions ECG interpretation in athletes can be improved by using a standardised ECG criteria tool. Use of the tool results in lower false-positive rates; this may have implications for screening recommendations. Trial Registration number: ACTRN12612000641897.
Analysis and Digital Implementation of Cascaded Delayed-Signal-Cancellation PLL

Phase-locked loop (PLL) is usually required to detect grid phase angle in grid-tied converters. Conventional PLL schemes have to compromise between steady-state accuracy and transient dynamics when grid voltage is polluted by unbalance and harmonics. To overcome this challenge, a generalized delayed-signal-cancellation (DSC) operator is proposed recently to form cascaded DSC (CDSC) operator to eliminate arbitrary harmonics. With the CDSC operator, the conditioned voltage can be used in PLL loop with very high bandwidth for fast tracking. However, for digital implementation, the CDSC operator may subject to delay-time error, which subsequently leads to residual distortions in the conditioned voltage. In this paper, a thorough analysis of the CDSC operator in both synchronous and stationary reference frames is first conducted. The discretization error during digital implementation due to nonideal system sampling frequency and/or grid-frequency variation is quantified with the proposed concept of relative harmonic gain error. An effective improvement method is then developed that is based on linear interpolation and is effective for all delay-based PLL schemes. Finally, experimental results are obtained to verify the harmonic elimination ability of CDSC in various scenarios and the effectiveness of the interpolation-based digital implementation scheme.
Comparison of preoperative oral acetazolamide and intraperitoneal normal saline irrigation for reduction of postoperative pain after laparoscopic cholecystectomy.

PURPOSE Visceral and shoulder tip pain following laparoscopic cholecystectomy is mainly due to carbon dioxide (CO2) insufflation. Various methods have been adopted to eliminate residual CO2. We compared the postoperative analgesic efficacy of intraperitoneal normal saline (30 mL/kg) irrigation with preoperative oral acetazolamide administration in patients undergoing laparoscopic cholecystectomy. MATERIALS AND METHODS Sixty patients between 20 and 60 years of age were included in this prospective, randomized, double-blind study. Patients in Group I received placebo, Group II patients received preoperative oral acetazolamide (5 mg/kg), and Group III patients received intraperitoneal irrigation with 30 mL/kg of normal saline. Intravenous paracetamol (1 g) was administered every 6 hours for postoperative analgesia. Parietal and visceral pain scores at rest, on movement, and on coughing and shoulder tip pain were recorded using a visual analog scale after arrival in the postanesthesia care unit, at 1, 2, 4, 6, 12, and 24 hours after surgery. Rescue analgesia was provided with an intravenous fentanyl (1 μg/kg) bolus whenever the visual analog scale score was ≥4. RESULTS Compared with Group I, Group III patients had significantly lower visceral pain scores at all time intervals except at 12 hours. Group III patients also recorded significantly lower visceral pain scores than Group II from 2 to 24 hours. There was no significant difference in shoulder tip pain. The total dose of fentanyl used was significantly less in Group III. CONCLUSIONS Intraperitoneal normal saline irrigation is more effective than acetazolamide in reducing postoperative visceral pain after laparoscopic cholecystectomy and has significant opioid-sparing effect. However, its effect on shoulder pain is comparable to that of acetazolamide.
Memristor-based redundant binary adder

This paper introduces a memristor based redundant binary adder for canonic signed digit code, that coding eliminates the carry and provides a carry-free addition. The proposed binary adder circuit tries to achieve high addition speed that is independent on the length of the data using the accumulation property of a Nano-element called a memristor. The general block diagram of the proposed circuit is illustrated based on memristors and its operation has been validated using HP memristor model and simulated via different examples using PSPICE showing a great match.
Omega-Gate p-MOSFET With Nanowirelike SiGe/Si Core/Shell Channel

We demonstrated, for the first time, p-MOSFETs (LG ges 40 nm) with SiGe/Si core/shell channel integrated on bulk Si using a CMOS-compatible top-down processes. The Omega-shaped nanowire (NW)-like channels comprised of ~12-nm-thick inner SiGe core and 4-nm-thick outer Si shell. The devices exhibited good subthreshold characteristics (with SS ~128 mV/dec), suggesting successful surface passivation of the SiGe NW body by the outer Si capping layer. Drive currents of ~167 muA/mum is achieved, which is 15% enhancement over the reference Si-channel devices fabricated by the same process. Double gm peaks are observed at low drain bias for the core/shell SiGe NW devices, confirming the quantum confinement of holes in the SiGe inner core.
Safety and Efficacy of the Early Introduction of Everolimus With Reduced-Exposure Cyclosporine A in De Novo Kidney Recipients

Background Everolimus and cyclosporine A (CsA) exhibit synergistic immunosuppressive activity when used in combination. We examined the safety and efficacy of the use of everolimus with a cyclosporine-sparing strategy in de novo renal transplant recipients. Methods A comparative, parallel, randomized, open-label 1-year study has been performed in 148 patients from five transplant centers to compare the efficacy and tolerability of everolimus and reduced exposure CsA (the investigational group) or enteric-coated mycophenolate sodium and standard-exposure CsA (the control group) in combination with basiliximab and steroids. The eligible subjects were randomly assigned at 1 month after transplantation. Efficacy failure (biopsy-proven acute rejection, death, graft loss, or loss to follow-up), safety, and renal function were evaluated. Results One graft loss has been reported in the control group and no patient death were reported in either group. The incidence of biopsy-proven acute rejection until 12 months after transplantation of the investigational group was 7.5%, compared to 11.1% of the control group (P=0.565). The mean estimated glomerular filtration rates of the investigational group at 12 months after transplantation was significantly higher (68.1±16.8 ml/min/1.73 m2) than that of the control group (60.6±15.8 ml/min/1.73 m2; P=0.016). There was no significant difference (P>0.05) in the incidence of discontinuations and serious adverse events between the groups. Conclusion The results of this study provide the evidences that (1) the calcineurin inhibitor (CNI) minimization by the introduction of everolimus after 1-month posttransplantation keeps the incidences of acute rejection and addtional risks as low as the conventional immunosuppression; (2) it allows minimizing CNI exposure, consequently reducing CNI nephrotoxicity and preserving renal function.
Senescence and Genetic Load: Evidence from Tribolium

After 40 generations in which young adults were killed shortly after the onset of reproduction, strains of Tribolium castaneum with significantly decreased median longevity evolved. These findings support the hypothesis that the longevity of a species is controlled by genetic factors, and represents a compromise between selection for longer reproductive period and the limit set by environmental hazards.
Severity of non‐alcoholic steatohepatitis is associated with substitution of adipose tissue in skeletal muscle

The pathogenesis of non‐alcoholic fatty liver disease (NAFLD) is now focusing on its organ cross‐talk with not only adipose tissue but also systemic skeletal muscle. Cross‐sectional and longitudinal studies were conducted to determine the role of intramuscular adipose tissue content (IMAC) measured by computed tomography on the severity of NAFLD/non‐alcoholic steatohepatitis (NASH).
Generate and optimize fuzzy rules using the Particle Swarm Algorithm

The success of fuzzy application to solve the control problems depends on a number of parameters, such as fuzzy rules and membership functions. The problem of generating desirable fuzzy rules is very important in the development of fuzzy systems, which are usually decided upon subjectively. This paper describes a very simple and straightforward fuzzy rule generation and optimization technique by using the Particle Swarm Optimization Algorithm (PSO). The proposed algorithm can obtain a set of fuzzy rules which cover the examples set in iterative process. The proposed method is tested with promising results.
Estimation of whole‐body SAR from electromagnetic fields using personal exposure meters

In this article, personal electromagnetic field measurements are converted into whole‐body specific absorption rates for exposure of the general public. Whole‐body SAR values calculated from personal exposure meter data are compared for different human spheroid phantoms: the highest SAR values (at 950 MHz) are obtained for the 1‐year‐old child (99th percentile of 17.9 µW/kg for electric field strength of 0.36 V/m), followed by the 5‐year‐old child, 10‐year‐old child, average woman, and average man. For the 1‐year‐old child, whole‐body SAR values due to 9 different radiofrequency sources (FM, DAB, TETRA, TV, GSM900 DL, GSM1800 DL, DECT, UMTS DL, WiFi) are determined for 15 different scenarios. An SAR matrix for 15 different exposure scenarios and 9 sources is provided with the personal field exposure matrix. Highest 95th percentiles of the whole‐body SAR are equal to 7.9 µW/kg (0.36 V/m, GSM900 DL), 5.8 µW/kg (0.26 V/m, DAB/TV), and 7.1 µW/kg (0.41 V/m, DECT) for the 1‐year‐old child, with a maximal total whole‐body SAR of 11.5 µW/kg (0.48 V/m) due to all 9 sources. All values are below the basic restriction of 0.08 W/kg for the general public. 95th percentiles of whole‐body SAR per V/m are equal to 60.1, 87.9, and 42.7 µW/kg for GSM900, DAB/TV, and DECT sources, respectively. Functions of the SAR versus measured electric fields are provided for the different phantoms and frequencies, enabling epidemiological and dosimetric studies to make an analysis in combination with both electric field and actual whole‐body SAR. Bioelectromagnetics 31:286–295, 2010. © 2009 Wiley‐Liss, Inc.
Supervised classification of PolSAR images using adaptive sample censoring strategy

In this paper, a supervised classification algorithm of polarimetric synthetic aperture radar (PolSAR) images based on SVM with training sample optimization is proposed. For the supervised strategy, three main steps are there including feature extraction, design of classifier and training of classifier. Firstly, some features of the PolSAR images are extracted by employing the target decomposition theories. Secondly, a strategy for optimizing training sample is applied on each of preliminary selected sample sets, of which an adaptive threshold is determined according to the statistics of the characteristics similarity. Finally, classification of a real PolSAR image is performed based on SVM with the refined training sample sets. The experimental results have proven that the proposed algorithm is able to improve the quality of the samples and also the classification accuracy and the robustness of the classification algorithm for PolSAR images.
Study on domain-specific search engine and its automated generation

As web information expands, vertical search engine plays a more and more important role in search industry. With ldquobeing the best in specialized utilization fieldrdquo in mind, we develop domain-specific 114 search engine based on domain characteristics. Four advantages have been embodied in 114 search engine: quick response, high accuracy in domain, a significant enhancement of correlations between requirements and Info responses and automatically cross-domain engine building. Except short time-consuming and field generation automation, the reported experiments indicate that result pages of domain-specific 114 search engine have higher matching degrees towards user demands than the ones of Google in domain utilization.