Miracle-dz/UniFAR-FTUs huggingface dataset:
Syddansk Universitet The loss-of-function disease-mutation G 301 R in the Na + / K +-ATPase 2 isoform decreases lesion volume and improves functional outcome after spinal cord injury in mice

Background: The Na+/K+‐ATPases are transmembrane ion pumps important for maintenance of ion gradients across the plasma membrane that serve to support multiple cellular functions, such as membrane potentials, regulation of cellular volume and pH, and co‐transport of signaling transmitters in all animal cells. The α2Na +/K+‐ATPase subunit isoform is predominantly expressed in astrocytes, which us the sharp Na+‐gradient maintained by the sodium pump necessary for astroglial metabolism. Prolonged ischemia induces an elevation of [Na]i, decreased ATP levels and intracellular pH owing to anaerobic metabolism and lactate accumulation. During ischemia, Na+/K+‐ATPase‐related functions will naturally increase the energy demand of the Na+/K+‐ATPase ion pump. However, the role of the α2Na +/ K+‐ATPase in contusion injury to the spinal cord remains unknown. We used mice heterozygous mice for the loss‐ of‐function disease‐mutation G301R in the Atp1a2 gene (α2 +/G301R) to study the effect of reduced α2Na +/K+‐ATPase expression in a moderate contusion spinal cord injury (SCI) model. Results: We found that α2 +/G301R mice display significantly improved functional recovery and decreased lesion volume compared to littermate controls (α2 +/+) 7 days after SCI. The protein level of the α1 isoform was significantly increased, in contrast to the α3 isoform that significantly decreased 3 days after SCI in both α2 +/G301R and α2 +/+ mice. The level of the α2 isoform was significantly decreased in α2 +/G301R mice both under naïve conditions and 3 days after SCI com‐ pared to α2 +/+ mice. We found no differences in astroglial aquaporin 4 levels and no changes in the expression of chemokines (CCL2, CCL5 and CXCL1) and cytokines (TNF, IL‐6, IL‐1β, IL‐10 and IL‐5) between genotypes, just as no apparent differences were observed in location and activation of CD45 and F4/80 positive microglia and infiltrating
Assessment of functional improvement in the hemiparetic arm following focal rehabilitation intervention

s reviewed (n=468). Excluded: Not related to brain injury or stroke (n=676) Excluded: 1. Not used or no potential for use in focal intervention. (n=273) 2. No passive or active functional outcome measure used. (n=111). Outcome measures identified (n=20) Outcome measures reflecting ‘real life’ (n=6) LASIS MAL (4 versions 12, 14, 26, 28 items) ABILHAND Outcome measures evaluated (n=6) LASISpassive and lower level function-limited evaluation MAL (4 versions 12, 14, 26, 28 items) middle range of function –variable evaluation ABILHAND – higher-level bimanual and complex tasks with robust psychometric properties Stage 1 criteria
Safer Frother Option for Coal Flotation – A Review

A safer frother option for coal flotation in comparison with the common frother methyl isobutyl carbinol (MIBC) was searched and compared through literature review. Results of literature review and comparison of different frothers in safety and environmental aspects show that pine oil and DowFroth have a strong potential to replace MIBC since it has high flash point (78 °C, 149 °C, respectively), and dual frothing and collecting properties to be used as a stand-alone reagent for coal flotation. It can significantly reduce the risk of potential hazard associated with MIBC and oil collector.
Title Detection of sclerotic spine metastases via random aggregation of deep convolutional neural network classifications Permalink

Automated detection of sclerotic metastases (bone lesions) in Computed Tomography (CT) images has potential to be an important tool in clinical practice and research. State-of-the-art methods show performance of 79% sensitivity or true-positive (TP) rate, at 10 false-positives (FP) per volume. We design a two-tiered coarse-to-fine cascade framework to first operate a highly sensitive candidate generation system at a maximum sensitivity of ∼92% but with high FP level (∼50 per patient). Regions of interest (ROI) for lesion candidates are generated in this step and function as input for the second tier. In the second tier we generate N 2D views, via scale, random translations, and rotations with respect to each ROI centroid coordinates. These random views are used to train a deep Convolutional Neural Network (CNN) classifier. In testing, the CNN is employed to assign individual probabilities for a new set of N random views that are averaged at each ROI to compute a final per-candidate classification probability. This second tier behaves as a highly selective process to reject difficult false positives while preserving high sensitivities. We validate the approach on CT images of 59 patients (49 with sclerotic metastases and 10 normal controls). The proposed method reduces the number of FP/vol. from 4 to 1.2, 7 to 3, and 12 to 9.5 when comparing a sensitivity rates of 60%, 70%, and 80% respectively in testing. The Area-Under-the-Curve (AUC) is 0.834. The results show marked improvement upon previous work. ∗holger.roth@nih.gov, h.roth@ucl.ac. uk
AN ABSTRACT OF THE DISSERTATION OF

approved: Sinisa Todorovic This dissertation addresses the problem of video labeling at both the frame and pixel levels using deep learning. For pixel-level video labeling, we have studied two problems: i) Spatiotemporal video segmentation and ii) Boundary detection and boundary flow estimation. For the problem of spatiotemporal video segmentation, we have developed recurrent temporal deep field (RTDF). RTDF is a conditional random field (CRF) that combines a deconvolution neural network and a recurrent temporal restricted Boltzmann machine (RTRBM), which can be jointly trained end-to-end. We have derived a meanfield inference algorithm to jointly predict all latent variables in both RTRBM and CRF. For the problem of boundary detection and boundary flow estimation, we have proposed a fully convolutional Siamese network (FCSN). The FCSN first estimates object boundaries in two consecutive frames, and then predicts boundary correspondences in the two frames. For frame-level video labeling, we have specified a temporal deformable residual network (TDRN) for temporal action segmentation. TDRN computes two parallel temporal processes: i) Residual stream that analyzes video information at its full temporal resolution, and ii) Pooling/unpooling stream that captures long-range visual cues. The former facilitates local, fine-scale action segmentation, and the latter uses multiscale context for improving the accuracy of frame classification. All of our networks have been empirically evaluated on challenging benchmark datasets and compared with the state of the art. Each of the above approaches has outperformed the state of the art at the time of our evaluation. c ©Copyright by Peng Lei December 7, 2018 All Rights Reserved Pixeland Frame-level Video Labeling using Spatial and Temporal Convolutional Networks
The Effect of Applying Software Design Patterns on Real Time Software Efficiency

Real time applications are one of the fastest growing applications in the market due to their popularity, business value and the fact that web is their native environment. As a result, enhancing the performance of these applications has always been a concern for the IT industry. In this research, we took a closer look on the effect of design patterns on the performance of these applications using simulations as a research method. Two of the design patterns used by the researchers, namely, the Observer and the State design patterns, proved to be more effective in terms of software efficiency. Keywords—Design patterns; real time software; real time applications; software performance; software efficiency
Endoplasmic Reticulum Stress is Reduced in Tissues of Obese Subjects after Weight Loss Short running title : ER Stress is Reduced by Weight Loss in Obesity

Objective. Obesity is associated with insulin resistance and type 2 diabetes, although the mechanisms linking these pathologies remain undetermined. Recent studies in rodent models revealed endoplasmic reticulum (ER) stress in adipose and liver tissues and demonstrated that ER stress could cause insulin resistance. Therefore, we tested whether these stress pathways were also present in obese human subjects and/or regulated by weight loss. Research Design and Methods. Eleven obese men and women (BMI: 51.3 ± 3.0 kg/m 2 ) were studied before and 1 year after gastric bypass (GBP) surgery. We examined systemic insulin sensitivity using hyperinsulinemic-euglycemic clamp studies before and after surgery and collected subcutaneous adipose and liver tissues to examine ER stress markers. Results. Subjects lost 39 9% body weight at 1 year after GBP surgery (p<0.001), which was associated with a marked improvement in hepatic, skeletal muscle and adipose tissue insulin sensitivity. Markers of ER stress in adipose tissue significantly decreased with weight loss. Specifically, Grp78 and spliced XBP-1 mRNA levels were reduced, as were phosphorylated eIF2 and stress kinase JNK1 (all p values <0.05). Liver sections from a subset of subjects showed intense staining for Grp78 and phosphorylated eIF2 before surgery, which was reduced in post-GBP sections. Conclusions. This study presents important evidence that ER stress pathways are present in selected tissues of obese humans, and that these signals are regulated by marked weight loss and metabolic improvement. Hence, this suggests the possibility of an integral relationship between obesity-related ER stress and metabolic dysfunction in obese humans.
Improving Online Multi-Person Tracking Occlusion : Scale Loss for Deep ReID Feature Learning

Occlusion and crossing in Multi-Person Tracking always influence the tracking results. In this paper, we show how deep Re-Identification (ReID), which aims at matching pedestrians across non-overlapping video cameras, can be used to improve the occlusion problem on tracking. The learned ReID feature is more robust than other features used in traditional trackers because the training set is collected from different cameras which includes different parts of the same person. This also helps to solve the occlusion problem in tracking. We train a neural network with the designed scale loss which normalizes both weight vectors and output features to remove the effect of their scale variations on a large Person ReID dataset offline to learn the deep ReID model and build a framework combining detector and tracker to meet real-world application requirements. During the online tracking stage, the data association is solved by calculating the cosine distance cost matrix according to the learned ReID feature vectors. Experiments show that using ReID features can effectively reduce the occlusion index data on MOTChallenge, and the scale loss performs well. Overall our method achieves competitive performance on MOTChallenge, and the framework guarantees the running speed in real-time.
Image-based modeling for better understanding and assessment of atherosclerotic plaque progression and vulnerability : Data , modeling , validation , uncertainty and Citation

Medical imaging and image-based modeling have made considerable progress in recent years in identifying atherosclerotic plaque morphological and mechanical risk factors which may be used in developing improved patient screening strategies. However, a clear understanding is needed about what we have achieved and what is really needed to translate research to actual clinical practices and bring benefits to public health. Lack of in vivo data and clinical events to serve as gold standard to validate model predictions is a severe limitation. While this perspective paper provides a review of the key steps and findings of our group in image-based models for human carotid and coronary plaques and a limited review of related work by other groups, we also focus © 2014 Elsevier Ltd. All rights reserved. Correspondence to: School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, China / Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609, USA. Conflict of interest statement: There is no conflict of interest with any other individuals or government in the paper. NIH Public Access Author Manuscript J Biomech. Author manuscript; available in PMC 2015 March 03. Published in final edited form as: J Biomech. 2014 March 3; 47(4): 834–846. doi:10.1016/j.jbiomech. 2014.01. 012. N IH -P A A uhor M anscript N IH -P A A uhor M anscript N IH -P A A uhor M anscript on grand challenges and uncertainties facing the researchers in the field to develop more accurate and predictive patient screening tools.
Employment sub-centres and the choice of mode of travel to work in the Dublin region

In this paper, travel-to-work patterns are analysed for a number of key employment sub-centres in the Dublin region. Geographical Information System (GIS) visualisations and regression analysis are used to identify a small number of employment sub-centres using a large sample of travel to work data from the 2002 Census of Population modified with travel-specific data by the Dublin Transportation Office. The journey to work is then analysed across these employment sub-centres in the context of a travel mode choice model. The estimation results illustrate the varying effects that travel attributes such as travel time and travel cost have on the choice of mode of travel across employment destinations highlighting the role of trip destination as a main driver of travel behaviour in the Dublin region.
Introductions : Semantic and syntactic analysis

This study aims to investigate the semantic and syntactic features of verbs used in the introduction section of Applied Linguistics research articles published in Iranian and international journals. A corpus of 20 research article introductions (10 from each journal) was used. The corpus was analysed for the syntactic features (tense, aspect and voice) and semantic meaning of verbs. The findings showed that in both groups of introductions, the common tenses were the present and past, rather than future. In introductions published in the international journal, the present tense was used more often than in those published in the Iranian journal, whereas past tense was used twice as frequently in Iranian journal introductions. Regarding the aspect of verbs, the simple aspect was common in both groups of introductions, but more frequent in Iranian journal introductions. The perfect aspect was more common in international journal introductions. Concerning voice, the active voice was predominant in both groups of introductions. Semantically, verbs with mental, activity, communication and existence meanings were common in both groups. The semantic meanings of verbs were not significantly different in the two groups of introductions. The findings of this study can have implications for novice, nonnative writers in Applied Linguistics in helping them design and write more appropriate research article introductions.
Explorer Semantic Parsing with Bayesian Tree Transducers

Many semantic parsing models use tree transformations to map between natural language and meaning representation. However, while tree transformations are central to several state-of-the-art approaches, little use has been made of the rich literature on tree automata. This paper makes the connection concrete with a tree transducer based semantic parsing model and suggests that other models can be interpreted in a similar framework, increasing the generality of their contributions. In particular, this paper further introduces a variational Bayesian inference algorithm that is applicable to a wide class of tree transducers, producing state-of-the-art semantic parsing results while remaining applicable to any domain employing probabilistic tree transducers.
The remarkable promotional e ff ect of SO 2 on Pb-poisoned V 2 O 5-WO 3 / TiO 2 T catalysts : An in-depth experimental and theoretical study

• SO2 increased the activity of Pb-poi-soned commercial V-based SCR cata-lysts. • SO2 recovered the Brønsted acid sites on surface of the Pb-poisoned catalyst. • A surface bidentate sulfate was formed on surface of the Pb-poisoned catalyst. • Adsorption of SO2 and NH3 on surface was studied by DFT. A R T I C L E I N F O
Simulation of a Heisenberg XY-chain and realization of a perfect state transfer algorithm using liquid nuclear magnetic resonance

X iv :q ua nt -p h/ 05 03 19 9v 2 3 1 M ar 2 00 5 Simulation of a Heisenberg XYchain and realization of a perfect state transfer algorithm using liquid nuclear magnetic resonance ∗ Jingfu Zhang1, Gui Lu Long1,4, Wei Zhang2, Zhiwei Deng2, Wenzhang Liu1, and Zhiheng Lu3 Key Laboratory For Quantum Information and Measurements of MOE, and Department of Physics, Tsinghua University, Beijing, 100084, P R China Testing and Analytical Center, Beijing Normal University, Beijing, 100875, P R China Department of Physics, Beijing Normal University, Beijing, 100875, P R China 4 Key Laboratory For Atomic and Molecular Nanosciences, Tsinghua University, Beijing 100084, P R China (Dated: November 20, 2018)
Hudsson as a multiplying plant for three species of arbuscular mycorrhizal fungi ( AMF ) : Glomus clarum

Mentha piperita as a multiplying of arbuscular mycorrhizal fungi. The objective of this work was to evaluate Mentha piperita Hudsson as a multiplying plant for three species of arbuscular mycorrhizal fungi (AMF): Glomus clarum Nicol. & Schenck, Glomus etunicatum Becker & Gerd. and Acaulospora scrobiculata Trappe. For this, young stem cuttings of Mentha piperita in esterilized substratum consisting of coconuts fiber and carbonized rice husk (1:1, v:v) were used in Seedling trays of two different cell-size (40 or 100 ml; 12x6 cells/tray) containing 10 g AMF soil inocolum of each species. Twelve stem cuttings were grown in each plot, with four subdivided replicates and eight treatment. Two weeks after the rooting, the stem cuttings were transplanted to 5 liter polyethylene bags. Ninety days after the transplant, the plants showed colonization of 91,5%, 94% and 98% for the species A. scrobiculata, G. clarum and G. etunicatum, respectively. The three species of AMF showed better vegetative development, in terms of number of leves, leaf area and fresh and dry matter of the aerial part. The most efficient species, G. etunicatum, presented 37% and 33% dry matter gain over non inoculated plants when grown on larg and small alveolus, respectively. We concluded that Mentha piperita can be used to multiply the three AMF species; however, to attain higher dry matter of the aerial part, it must be inoculated with G. etunicatum, using the alveolus of bigger volume.
Al-Janabi, Zane (2018)A study of sibling relations: does having an older sibling impact on an individual’s goal orientated behaviour? Manchester

Little is known about a sibling relationship within the psychology field. Family studies focus on dynamics such as birth-order, and family size, whilst neglecting individual’s perspectives and sibling relations. The role of sibling relationships and goal-orientated behaviour were the focus of this study. Three male and four female younger siblings’ attitudes were collected using semi-structured interviews. Participants were encouraged to talk about their own experience with having an older sibling whilst growing up. Four themes suggested having an older sibling motivates and deters goal-orientated behaviour. When an older sibling offers guidance and support towards a younger brother/sister, this acts as a motivator to maintain goal-orientated behaviour. Competition amongst siblings can lead to an individual developing an ‘avoiding goalorientated behaviour’ due to feeling they may fail to achieve at the same standard as their sibling. Competition and high expectancy may also lead to developing ‘goal-orientated’ behaviour, as siblings may differentiate in the types of goals set, and direction in life, known as ‘Sibling Deindividualisation’. Future research should focus on same sex sibling influences and oldest sibling perspective to build on research. Having an older sibling does impact an individual’s goal-orientated behaviour in a reinforcing or deterring manner depending on the relationship.
Swampy territory: The role of the palliative care social worker in safeguarding children of adults who are receiving specialist palliative care

This qualitative study explores the role of the palliative care social worker in safeguarding and promoting the welfare of children of adults who are receiving specialist palliative care. It examines what palliative care social workers understand by the term 'safeguarding children' and how they and other members of the palliative care multidisciplinary team identify situations where there are concerns about the present and future care of a child. These concerns could have existed prior to, arisen because of, been exacerbated by, or become evident because of the parent's illness. The purpose of the study was to both draw and analyse the picture of the 'real-life' work of the palliative care social workers with children and their families. This included the palliative care social workers' perception of the quality of their relationship with the local authority children's services as well as a consideration of the support and training they receive to help them in their task of safeguarding children.
econstor Make Your Publications Visible . A Service of zbw

This paper analyzes European financial markets’ comprehension and interpretation of ECB communication signals. By applying a novel indicator developed by Berger et al. (2006), that quantifies the contents of the ECB’s introductory statements, we find that communication affects the term structure of interest rates in the medium run over a horizon between five months to one year. Our results suggest that financial market agents expect the ECB to prepare them for a change in interest rates well in advance. However, judging upon the dynamics of the response, the exact timing of a decision is less foreseeable. Disentangling the effects of ECB statements on prices, the real and the monetary sector, we provide evidence that especially the ECB’s interpretation and forecasts of price developments represent important news to financial market agents. JEL classification: E43, E44, E58
Unbalanced-Excitation Spiral Antenna

This paper describes a two-arm unbalanced-excitation spiral antenna, where one arm is fed by the inner conductor of a coaxial line and the other is short-circuited to a conducting cavity that backs the spiral. Analysis is performed over a frequency range of 1 GHz to 10 GHz. The input resistance for the unbalanced-excitation spiral is smaller than that for the corresponding balanced-excitation spiral. The radiation is circularly polarized within the analysis frequency range. The unbalanced-excitation spiral exhibits a frequency response for the gain that is similar to that of the balanced-excitation spiral.
Relationship between 800m Running Performance and Aerobic and Anaerobic Energy Metabolism Capacities in Well-Trained Middle-Distance Runners

1Department of Sport Research, Japan Institute of Sport Sciences, 3-15-1 Nishigaoka, Kita-ku, Tokyo 115-0056, Japan fumiya.tanji@jpnsport.go. jp 2Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8574, Japan 3Nagoya Senior High School, 2-1-58, Sunada-bashi, Higashi-ku, Nagoya, Aichi 461-8676, Japan 4Faculty of Health and Sport Science, University of Tsukuba,1-1-1 Tennodai, Tsukuba, Ibaraki 305-8574, Japan [Received July 20, 2017; Accepted March 29, 2018; Published online April 11, 2018]