Miracle-dz/UniFAR-FTUs huggingface dataset:
Diagnosis of pericardial effusion in birds by ultrasound

Advice on control of CIBD is speculative but includes reduction of all parasite challenge. A clean grazing policy would also avoid the related but separate condition of chronic gut damage and hypersensitivity (anthelmintic unresponsive diarrhoea) caused by repeated larval nematode challenge, even in the face of repeated anthelmintic treatments, as described by Suttle (1995). Other factors involved in the aetiology of CIBD could include viruses, for example, ovine herpes virus 2, bovine viral diarrhoea virus, bovine leukaemia virus, specific dietary allergens and a genetic predisposition. Neither Border disease virus nor maedi-visna was present in the study flock as determined by repeated serological testing. Conversely, lymphoma was diagnosed sporadically in the study flock and has been seen concurrently with chronic lymphocytic enteritis in a Canadian flock (Rae 1994); thus, a connection may exist between these conditions. CIBD should be considered as a differential diagnosis in sheep aged three years or younger, showing poor growth or illthrift with ruminal hypomotility, dullness, pasty faeces with negative results for parasitic infestations, trace element deficiencies and paratuberculosis. More conventional intensively managed flocks may be at risk from the condition since similar pathology has been seen in illthriven six-month-old Suffolk lambs after an extended housing period (D. J. Wilson, P. R. Scott, unpublished data).
Proteoglycan turnover during development of spontaneous osteoarthrosis in guinea pigs.

OBJECTIVE The study was performed to clarify the metabolic background of the variations in proteoglycan concentrations, relating to ageing and the spontaneous development of osteoarthrosis in guinea pigs. METHODS Six-, 9- and 12-month-old Hartley guinea pigs were injected intraperitoneally with Na2(35)SO4. The incorporation and degradation of various proteoglycans were analyzed in different areas of tibial articular cartilage during the development of osteoarthrosis. RESULTS Proteoglycan synthesis was most active in the uncalcified cartilage of 6-month animals and highest in the medial compartment with its presumably higher load. The breakdown of proteoglycans decreased with age. The onset of osteoarthrosis was associated with decreased synthesis of large and small proteoglycans, while the rate of degradation remained unchanged. CONCLUSION During onset of osteoarthrosis the synthesis of large proteoglycans gradually becomes insufficient to compensate for the simultaneous degradation. This differs from findings in more rapidly progressing, experimental secondary osteoarthrosis, where a substantial increase in the rate of degradation is more conspicuous.
Improving the Performance of Human Detection Technique using Cascaded Support Vector Machine

Human detection plays an important role in security surveillance and computer vision. The process of human detection is very complex due to variant feature of human such as color, texture and shape and size. The process of feature extraction imparts a major role in human detection technique. Now a days used classification technique to define the feature of human. The classification process define the pattern of feature for the process of detection, the process of features generates a bag of feature for the process of classification technique. In this paper improved the support vector machine classification technique for the classification of human detection. The improved support vector machine is called cascaded support vector machine. The cascading of support vector machine improved the process of human detection. Our proposed algorithm implemented in MATLAB 7.8. 0 software and used human video of different location. Our empirical evaluation of experimental result shows that the proposed methods give a better result in compression of support vector machine classifier.
Phase II Randomized Study of Figitumumab plus Docetaxel and Docetaxel Alone with Crossover for Metastatic Castration-Resistant Prostate Cancer

Purpose: Figitumumab is a human IgG2 monoclonal antibody targeting insulin-like growth factor 1 receptor (IGF-1R), with antitumor activity in prostate cancer. This phase II trial randomized chemotherapy-naïve men with progressing castration-resistant prostate cancer to receive figitumumab every 3 weeks with docetaxel/prednisone (Arm A) or docetaxel/prednisone alone (Arm B1). At progression on Arm B1, patients could cross over to the combination (Arm B2). Experimental Design: Prostate-specific antigen (PSA) response was the primary endpoint; response assessment on the two arms was noncomparative and tested separately; H0 = 0.45 versus HA = 0.60 (α = 0.05; β = 0.09) for Arm A; H0 = 0.05 versus HA = 0.20 (α = 0.05, β = 0.10) for Arm B2. A comparison of progression-free survival (PFS) on Arms A and B1 was planned. Results: A total of 204 patients were randomized and 199 treated (Arm A: 97; Arm B1: 102); 37 patients crossed over to Arm B2 (median number of cycles started: Arm A = 8; B1 = 8; B2 = 4). PSA responses occurred in 52% and 60% of Arms A and B1, respectively; the primary PSA response objective in Arm A was not met. Median PFS was 4.9 and 7.9 months, respectively (HR = 1.44; 95% confidence interval, 1.06–1.96). PSA response rate was 28% in Arm B2. The figitumumab combination appeared more toxic, with more treatment-related grade 3/4 adverse events (75% vs. 56%), particularly hyperglycemia, diarrhea, and asthenia, as well as treatment-related serious adverse events (41% vs. 15%), and all-causality grade 5 adverse events (18% vs. 8%). Conclusion: IGF-1R targeting may merit further evaluation in this disease in selected populations, but combination with docetaxel is not recommended. Clin Cancer Res; 20(7); 1925–34. ©2014 AACR.
Dome Truncation for Management of the Overprojected Nasal Tip

The nasal tip highlights the facial profile, and in its most aesthetic configuration subtly projects anterior to the dorsum to create a soft supratip break. Overprojection of the tip in relation to the vertical facial plane and the nasal dorsum represents one variant of nasal-facial disproportion that can adversely affect an otherwise pleasant facial appearance. Several strategies for reducing either the lateral or the medial crus to deproject the tip have been suggested. This article describes a method of direct truncation of the dome using an external rhinoplasty approach that can reliably produce tip retrodisplacement while maintaining, or enhancing, tip rotation. Tip definition and projection are optimized by precise, direct reduction of the overprojected dome region and accurate sculpting and realignment of the remaining crural units. When the tip is retrodisplaced, alar flaring can occur; therefore, alar base reduction can substantially enhance the final outcome.
Gapped radial H-Guide Aperture Antenna

In this paper, a new H-guide antenna has been presented. The obtained results show that the proposed antenna can achieve approximately 12.0 dBi of gain at 9 GHz and has acceptable return loss from 8 to 10 GHz. Furthermore, the radiation patterns and insertion loss of the antenna have been presented and discussed.
A Two-stage Iterative Successive Detection Algorithm for V-BLAST Code

V-BLAST (Vertical Bell Lab Layered Space-time) is an attracting space-time code structure because it can get significantly higher capacity than SISO system in Rayleigh fading environments. To optimize BER, computational complexity, time delay or other targets, many different detection algorithms are proposed in recent years. In this paper, we proposed a two-stage detection algorithm for V-BLAST, in the first stage, conventional algorithm such as ZF, MMSE is used; in the second stage, based on the detection result of the front stage, we adopt an iterative successive symbol cancellation algorithm to obtain better BER performance at a little cost. The effect of iterations and different cancellation order are also analyzed in our paper. Furthermore, we adopt partial successive symbol cancellation in our structure to avoid error propagation
Consistent intensity correction of MR images

In the last few years, there has been an increasing number of research project to study the brain. These projects nowadays involve various research centers and deal with large databases of 3D images. However, the intensity of similar anatomical tissues is often different because of the acquisition process. This is problematic since the analysis of MR images (registration, segmentation and voxel-based algorithms) may rely on the hypothesis that corresponding anatomical points have a similar luminance. In this paper, a new fully-automatic method to correct for intensity differences in MR images is presented that does not require spatial alignment. We show that the intensity correction significantly improves a nonrigid registration algorithm.
Extending technology-aided leisure and communication programs to persons with spinal cord injury and post-coma multiple disabilities

Abstract Purpose: These two studies extended technology-aided programs to promote leisure and communication opportunities to a man with cervical spinal cord injury and a post-coma man with multiple disabilities. Method: The studies involved the use of ABAB designs, in which A and B represented baseline and intervention phases, respectively. The programs focused on enabling the participants to activate songs, videos, requests, text messages, and telephone calls. These options were presented on a computer screen and activated through a small pressure microswitch by the man with spinal cord injury and a special touch screen by the post-coma man. To help the latter participant, who had no verbal skills, with requests and telephone calls, series of words and phrases were made available that he could activate in those situations. Results: Data showed that both participants were successful in managing the programs arranged for them. The man with spinal cord injury activated mean frequencies of above five options per 10-min session. The post-coma man activated mean frequencies of about 12 options per 20-min session. Conclusions: Technology-aided programs for promoting leisure and communication opportunities might be successfully tailored to persons with spinal cord injury and persons with post-coma multiple disabilities. Implications for Rehabilitation Technology-aided programs may be critical to enable persons with pervasive motor impairment to engage in leisure activities and communication events independently. Persons with spinal cord injury, post-coma extended brain damage, and forms of neurodegenerative disease, such as amyotrophic lateral sclerosis, may benefit from those programs. The programs could be adapted to the participants’ characteristics, both in terms of technology and contents, so as to improve their overall impact on the participants’ functioning and general mood.
Daily self-disclosure and sleep in couples.

OBJECTIVE An emerging literature provides evidence for the association between romantic relationship quality and sleep, an important factor in health and well-being. However, we still know very little about the specific relationship processes that affect sleep behavior. Therefore, the goal of this study was to examine how self-disclosure, an important relational process linked to intimacy, relationship satisfaction, and health, is associated with sleep behavior. METHOD As part of a larger study of family processes, wives (n = 46) and husbands (n = 38) from 46 cohabiting families completed 56 days of daily diaries. Spouses completed evening diaries assessing daily self-disclosure, relationship satisfaction, and mood and morning diaries assessing the prior night's sleep. Multilevel modeling was used to explore the effects of both daily variation in and average levels across the 56 days of self-disclosure on sleep. RESULTS Daily variation in self-disclosure predicted sleep outcomes for wives, but not for husbands. On days when wives self-disclosed more to their spouses than their average level, their subjective sleep quality and sleep efficiency that night improved. Furthermore, daily self-disclosure buffered the effect of high negative mood on sleep latency for wives, but not husbands. In contrast, higher average levels of self-disclosure predicted less waking during the night for husbands, but not for wives. CONCLUSION The association between self-disclosure and sleep is one mechanism by which daily relationship functioning may influence health and well-being. Gender may play a role in how self-disclosure is associated with sleep.
Combined fair packet scheduling policy and multi‐class adaptive CAC scheme for QoS provisioning in multimedia cellular networks

In this paper, we propose a combined multi‐class adaptive connection admission control algorithm and a new fair packet scheduling policy, based on an enhanced weighted fair queuing algorithm. It takes into account a realistic behaviour of traffic while considering the spatial variation of the system characterizing both the user mobility and the signal propagation impairments due to the surrounding effects. The proposed allocation scheme provides enhanced traffic performance in heterogeneous environments and achieves a good level of capacity gain. The new adaptive quality of service (QoS) oriented connection admission control (CAC) function is proposed to meet the rapidly increasing demand for providing multimedia services with diversified quality requirements. It decides whether the connection request is to be admitted into the system, on the basis of the generated interference level and the waiting time before access. This CAC scheme, based on service class differentiation, aims at maximizing the use of available radio resource and meeting the QoS requirement of higher priority users as much as possible while maintaining the minimum requirements of lower priority users, especially when the system suffers from congestion. The results indicate that significantly increased traffic performance can be achieved in comparison with other conventional investigated policies. Copyright © 2006 John Wiley & Sons, Ltd.
Through an ITIM-Independent Mechanism the FcγRIIB Blocks B Cell Activation by Disrupting the Colocalized Microclustering of the B Cell Receptor and CD19

B cell activation is regulated through the interplay of the BCR with the inhibitory coreceptor FcγRIIB and the activating coreceptor CD19. Recent studies suggest that Ag-driven BCR microclusters are efficiently converted to a signaling active state on colocalization with CD19 microclusters. Using total internal reflection fluorescence microscopy–based, high-resolution, high-speed live-cell and molecule imaging approaches, we show that when co-ligated to the BCR, the FcγRIIB can inhibit B cell activation by blocking the colocalization of BCR and CD19 microclusters within the B cell immunological synapse. Remarkably, this inhibitory function of FcγRIIB is dependent not on its well-characterized ITIM-containing cytoplasmic domain, but its transmembrane domain. Indeed, human primary B cells from systemic lupus erythematosus patients homozygous for gene encoding the loss-of-function transmembrane domain mutant FcγRIIB-I232T fail to block the synaptic colocalization of the BCR with CD19, leading to dysregulated recruitment of downstream signaling molecule p-PI3K to membrane proximal signalosome. This inhibitory function of FcγRIIB in impairing the spatial-temporal colocalization of BCR and CD19 microclusters in the B cell immunological synapse may help explain the hyper-reactive features of systemic lupus erythematosus patient B cells in reported studies. These observations may also provide new targets for therapies for systemic autoimmune disease.
Magnetic resonance imaging to detect local tissue reactions after vaccination in sheep in vivo

Objectives Vaccination is one of the most effective methods to keep up the health status in humans and in livestock. Therefore, farm animals are vaccinated several times during their lifetime. Although vaccines are being checked regarding their local reactogenicity, side effects occur frequently—especially in the case of the application of adjuvanted products. Many reports exist about local reactions in sheep. The present study aimed at testing MRI as a method to document injection site reactions three-dimensionally. Design Two groups of Merino lambs (n=16 each) were vaccinated subcutaneously into the left neck side. Two different, licensed inactivated vaccines were used. Both groups of lambs were anaesthetised and scanned using MRI at days 1, 3, 8, 15, 22 and 29 after vaccination. Setting The study was performed on a commercial-like farm. Participants Thirty-two Merino lambs entered the experiment, 16 male and 16 female ones (one animal died at day 22 after vaccination). At first examination day they were approximately three months old. Primary and secondary outcome measures Volume differences were measured between vaccination and control neck side to evaluate the time pattern of local tissue reactions. Results Local tissue reactions were visible on the skin surface and also appeared in deeper tissue layers on MRI. These deeper reactions would not have been found without MRI or, alternatively, without sacrificing the animals. Some of these extensive local reactions lasted for more than 29 days. Conclusions The in vivo MRI results proved suitable to record local tissue reactions in terms of three-dimensional extent over a longer period of time in large farm animals without the need to sacrifice test animals. A three-dimensional MRI examination of the injection site during regulatory licensing studies offers an objective evaluation that could be used in a benefit-risk assessment of veterinary vaccines. Trial registration number District Government of Upper Bavaria:55.2-1-54-2532-2-13.
Ovarian Cancer Follow-up: A Preliminary Comparison of 2 Approaches

Objective The aim of the study was to perform a preliminary comparison of quality of life (QoL) and patient satisfaction in individualized nurse-led follow-up versus conventional medical follow-up in ovarian cancer. Methods One hundred twelve women who received a diagnosis of ovarian, fallopian tube, or peritoneal cancer, completed primary treatment by surgery alone or with chemotherapy, irrespective of outcome with regard to remission, and expected survival of more than 3 months. Fifty-seven participants were randomized to individualized follow-up and 55 patients to conventional follow-up. Well-being was measured at baseline and at 3, 6, 12, and 24 months after randomization for QoL (QLQ-C30 [European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire], QLQ-Ov28), the Hospital Anxiety and Depression Scale (HADS), and a Patient Satisfaction Questionnaire (PSQ-III). The primary endpoints were the effects of follow-up on each of the scores (via hierarchical mixed-effects model) and on relapse-free time (via Cox model). The total cost of follow-up was compared between each group. Results There was evidence for a QoL and patient satisfaction benefit for individualized versus standard follow-up (QLQ-C30, P = 0.013; 95% confidence interval, −0.03 to −0.001; PSQ-III P = 0.002; 95% confidence interval, −0.003 to −0.015; QLQ-Ov28, P = 0.14). Hospital Anxiety and Depression Scale data provided no evidence in favor of either treatment (P = 0.42). Delivered to protocol individualized follow-up resulted in a delay in the presentation of symptomatic relapse (P = 0.04), although the effect on survival in this study is unknown. Cost was £700 lower on average for the individualized follow-up group, but the difference was not statistically significant at the 5% level (P = 0.07). Conclusions Individualized follow-up was superior to conventional follow-up in 3 of the 4 QoL and patient satisfaction surveys in this preliminary study. Further prospective studies are needed in a larger population. Trial registration number is ISRCTN59149551.
Depression and the Parenting of Young Children: Making the Case for Early Preventive Mental Health Services

Portions of this column are adapted, with permission of the copyright holder, from K. Lyons-Ruth, R. Wolfe, A. Lyubchik, J. Grogan, and R. Steingard. Depressive symptoms in parents of children under three: sociodemographic predictors, current correlates, and associated parenting behaviors. In: N. Halfon, M. Schuster, and K. McLearn, eds. The health and social conditions of young children in American families. [Submitted for publication. ]
Policy based architecture for the UMTS multimedia domain

Policy-Based Networking (PBN) is a novel technology that facilitates the management and operation of networks. The paper reports on the application of Policy-Based mechanisms for QoS control in the IP Multimedia Subsystem (IMS) of the 3/sup rd/ generation UMTS networks. The IMS was introduced in UMTS to provide high quality IP-based Multimedia Services in Mobile Networks. After an introduction into PBN technology and a generic network architecture to support end-to-end QoS control, the Policy Decision Function as specified in UMTS is shown. The limitations of the current state of the standardization are explained and extensions to provide Policy-Based end-to-end QoS control in single and multi-operator environments are proposed.
Rates and Determinants of 5-Year Outcomes After Atrial Fibrillation–Related Stroke: A Population Study

Background and Purpose— Demographic trends in atrial fibrillation (AF) incidence may yield a substantial rise in the societal burden of AF-related stroke (AF-stroke). Accurate population-wide outcome data are essential to inform health service planning to improve AF-stroke prevention, and provision of rehabilitation, nursing home, and community supports for AF-stroke survivors. Methods— We investigated rates and determinants of 5-year fatality, stroke recurrence, functional outcomes, and prescribing of secondary prevention medications in AF-stroke in the North Dublin Population Stroke Study. Ascertainment included hot and cold pursuit using multiple overlapping sources. Survival analysis was performed using lifetables and Kaplan–Meier survival curves, and Cox proportional hazard modeling was performed to identify predictors of death and recurrent stroke. Results— Five hundred sixty-eight patients with new stroke were identified, including 177 (31.2%) AF-stroke. At 5 years, 39.2% (confidence interval, 31.5–46.8) of ischemic AF-stroke patients were alive. Congestive heart failure, hypertension, age <65, 65–74 years, and ≥75 years, diabetes mellitus, prior stroke, transient ischemic attack or thromboembolism, vascular disease and female sex (CHA2DS2-VASc) score (hazard ratio [HR], 1.34; P<0.001), CHADS2 score (HR 1.42, P=0.004), National Institute of Health Stroke Scale (HR, 1.09; P<0.0001), and subtherapeutic international normalized ratio (<2.0) at stroke onset (HR, 3.29; P=0.003) were independently associated with 5-year fatality, whereas warfarin (HR, 0.40; P=0.001) and statin use after index stroke (HR, 0.52; P=0.005) were associated with improved survival. The 5-year recurrence rate after ischemic AF-stroke was 21.5% (confidence interval, 14.5–31.3). Trends toward greater risk of recurrence were observed for persistent AF (HR, 3.09; P=0.07) and CHA2DS2-VASc score (HR, 1.34; P=0.07). Nursing home care was needed for 25.9% of patients. Conclusions— AF-stroke is associated with considerable long-term morbidity, fatality, stroke recurrence, and nursing home requirement. Adequately resourced national AF strategies to improve AF detection and prevention are needed.