Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of Imaging Biomarkers in the Assessment of Sarcopenia

Background: The diagnosis of sarcopenia through clinical assessment has some limitations. The literature advises studies that include objective markers along with clinical assessment in order to improve the sensitivity and specificity of current diagnostic criteria. The decrease of muscle quality precedes the loss of quantity, so we studied the role magnetic resonance imaging biomarkers as indicators of the quantity and quality of muscle in sarcopenia patients. Methods: a cross-sectional analysis was performed to analyze what MR-derived imaging parameters correlate better with sarcopenia diagnostic criteria in women of 70 years of age and over (independent walking and community-dwelling women who were sarcopenic in accordance with EWGSOP criteria with muscle mass adjusted to Spanish population were chosen). Results: The study included 26 women; 81 ± 8 years old. A strong correlation was obtained between cineanthropometric variables (BMI; thigh perimeter and fat mass) and imaging biomarkers (muscle/fat ratio, fatty infiltration, muscle T2*, water diffusion coefficient, and proton density fat fraction) with coefficients around 0.7 (absolute value). Conclusions: Knowing the correlation of clinical parameters and imaging-derived muscle quality indicators can help to identify older women at risk of developing sarcopenia at an early stage. This may allow taking preventive actions to decrease disability, morbidity, and mortality in sarcopenia patients.
A new surgical approach of direct perineal wound full‐thick closure for perineal wound of abdominoperineal resection for rectal carcinoma: A prospective cohort trial

Perineal wound complications after APR have high morbidity in the colorectal surgical department. Although some approaches have been figured out to solve this clinical focus, the outcomes are still not satisfied. Herein, this prospective comparative clinical trial has been designed to evaluate a new surgical procedure of direct perineal wound full‐thick closure (DPWC), compared with conventional perineal wound closure (CPWC), with hopes of making wound healing with less complications. In addition, an evaluation of an incision negative wound pressure therapy, as another focus in this field, was also analysed in the DPWC group. A total of 44 participants in our department were recruited from March 2018 to March 2020, divided into two groups randomly, CPWC group and DPWC group. The patients' characteristics, such as age, gender, BMI, smoking, alcohol consumption, comorbidities, CEA level, and high‐risk of invasion, were recorded without statistical significance between the CPWC group and DPWC group. After the same standard abdominal phase, these two groups were performed in different perineal phases. And then, operative and postoperative outcomes were analysed with different statistical methods. Data on wound healing time and length of stay in the DPWC group were shorter than those in the CPWC group (P < .05). Furthermore, cases of wound infection within 30 days in the DPWC group were also less than that in the CPWC group (P < .05). However, no difference was found between the incisional negative pressure wound therapy assisted group (NPA group) and non‐ incisional negative pressure wound therapy assisted group (non‐NPA group). During this study, hypoalbuminemia, as an independent high‐risk factor, impacted perineal wound healing. (P = .0271) In conclusion, DPWC is a new surgical approach, which can lead to a better outcome than DPWC, and it can be another surgical procedure for clinicians. In addition, hypoalbuminemia should be interfered for avoiding perineal wound complications.
Effects of Depressive Symptoms, Feelings, and Interoception on Reward-Based Decision-Making: Investigation Using Reinforcement Learning Model

Background: In this study, we examined the relationships between reward-based decision-making in terms of learning rate, memory rate, exploration rate, and depression-related subjective emotional experience, in terms of interoception and feelings, to understand how reward-based decision-making is impaired in depression. Methods: In all, 52 university students were randomly assigned to an experimental group and a control group. To manipulate interoception, the participants in the experimental group were instructed to tune their internal somatic sense to the skin-conductance-response waveform presented on a display. The participants in the control group were only instructed to stay relaxed. Before and after the manipulation, the participants completed a probabilistic reversal-learning task to assess reward-based decision-making using reinforcement learning modeling. Similarly, participants completed a probe-detection task, a heartbeat-detection task, and self-rated scales. Results: The experimental manipulation of interoception was not successful. In the baseline testing, reinforcement learning modeling indicated a marginally-significant correlation between the exploration rate and depressive symptoms. However, the exploration rate was significantly associated with lower interoceptive attention and higher depressive feeling. Conclusions: The findings suggest that situational characteristics may be closely involved in reward exploration and highlight the clinically-meaningful possibility that intervention for affective processes may impact reward-based decision-making in those with depression.
Compressive Strength and Durability of FGD Gypsum-Based Mortars Blended with Ground Granulated Blast Furnace Slag

One new flue gas desulfurization (FGD) gypsum-based binder is attempted in this article, which is made up of FGD gypsum, ground granulated blast furnace slag (GGBS) and ordinary Portland cement (OPC). Influences of raw materials, chemical activators, and curing conditions on the compressive strength of this new binder-based mortar, as well as its durability performances and microscopic characteristics, are investigated in consideration of utilizing FGD gypsum as much as possible. Results show that the compressive strength of this new binder-based mortar under normal curing conditions could increase along with GGBS dosages from three days to 90 days. The compressive strength of one selected mix proportion (FG-4550), which contains the highest dosage of FGD gypsum (45 wt.%), is much the same as those containing the highest dosage of GGBS. A better compressive strength of FG-4550 under normal curing conditions could be gained if the fineness of GGBS is improved. The activated effect of CaCl2 on the compressive strength of FG-4550 is superior to that of Ca(OH)2 under steam curing conditions. FG-4550 shows a good capacity for resistance to water, a low shrinkage ratio, but poor compressive strength after 30 freeze-thaw cycles. Based on the mineralogy of X-ray diffraction, the morphology of scanning electron microscopy and the pore diameter distributions of 1H nuclear magnetic resonance, the compressive strength of this FGD gypsum-based mortar mainly depends on clusters of ettringite.
Medium‐Term Complications Associated With Coronary Artery Aneurysms After Kawasaki Disease: A Study From the International Kawasaki Disease Registry

Background Coronary artery aneurysms (CAAs) may occur after Kawasaki disease (KD) and lead to important morbidity and mortality. As CAA in patients with KD are rare and heterogeneous lesions, prognostication and risk stratification are difficult. We sought to derive the cumulative risk and associated factors for cardiovascular complications in patients with CAAs after KD. Methods and Results A 34‐institution international registry of 1651 patients with KD who had CAAs (maximum CAA Z score ≥2.5) was used. Time‐to‐event analyses were performed using the Kaplan–Meier method and Cox proportional hazard models for risk factor analysis. In patients with CAA Z scores ≥10, the cumulative incidence of luminal narrowing (>50% of lumen diameter), coronary artery thrombosis, and composite major adverse cardiovascular complications at 10 years was 20±3%, 18±2%, and 14±2%, respectively. No complications were observed in patients with a CAA Z score <10. Higher CAA Z score and a greater number of coronary artery branches affected were associated with increased risk of all types of complications. At 10 years, normalization of luminal diameter was noted in 99±4% of patients with small (2.5≤Z<5.0), 92±1% with medium (5.0≤Z<10), and 57±3% with large CAAs (Z≥10). CAAs in the left anterior descending and circumflex coronary artery branches were more likely to normalize. Risk factor analysis of coronary artery branch level outcomes was performed with a total of 893 affected branches with Z score ≥10 in 440 patients. In multivariable regression models, hazards of luminal narrowing and thrombosis were higher for patients with CAAs of the right coronary artery and left anterior descending branches, those with CAAs that had complex architecture (other than isolated aneurysms), and those with CAAs with Z scores ≥20. Conclusions For patients with CAA after KD, medium‐term risk of complications is confined to those with maximum CAA Z scores ≥10. Further risk stratification and close follow‐up, including advanced imaging, in patients with large CAAs is warranted.
Comparison of Vertebral and Femoral Strength Between White and Asian Adults Using Finite Element Analysis of Computed Tomography Scans

Given non‐optimal testing rates for dual‐energy X‐ray absorptiometry (DXA) and the high use of computed tomography (CT) in some Asian countries, biomechanical computed tomography analysis (BCT)‐based bone strength testing, which utilizes previously taken clinical CT scans, may improve osteoporosis testing rates. However, an understanding of ethnic differences in such bone strength measurements between Whites and Asians is lacking, which is an obstacle to clinical interpretation. Using previously taken CT and DXA scans, we analyzed bone strength and bone mineral density (BMD) at the hip and spine in two sex‐ and age‐matched community‐based cohorts, aged 40 to 80 years: Whites (Rochester, MN, USA) and Koreans (Seoul, South Korea). For both the spine and femur, the age dependence of bone strength was similar for both groups, White (n = 371; women n = 202, 54.5%) and Korean (n = 396; women n = 199, 50.3%). For both sexes, mean spine strength did not differ between groups, but femur strength was 9% to 14% higher in Whites (p ≤ 0.001), an effect that became non‐significant after weight adjustment (p = 0.375). For Koreans of both sexes, the fragile bone strength thresholds for classifying osteoporosis, when derived from regional DXA BMD T‐score references, equaled the clinically validated thresholds for Whites (in women and men, femoral strength, 3000 N and 3500 N; vertebral strength 4500 N and 6500 N, respectively). Using these thresholds, classifications for osteoporosis for Koreans based on bone strength versus based on DXA BMD T‐scores were consistent (89.1% to 94.4% agreement) at both the hip and spine and for both sexes. The BCT‐based, clinically validated bone strength thresholds for Whites also applied to Koreans, which may facilitate clinical interpretation of CT‐based bone strength measurements for Koreans. © 2020 American Society for Bone and Mineral Research (ASBMR).
Spatially Aware Dense-LinkNet Based Regression Improves Fluorescent Cell Detection in Adaptive Optics Ophthalmic Images

Retinal pigment epithelial (RPE) cells play an important role in nourishing retinal neurosensory photoreceptor cells, and numerous blinding diseases are associated with RPE defects. Their fluorescence signature can now be visualized in the living human eye using adaptive optics (AO) imaging combined with indocyanine green (ICG), which motivates us to develop an automated RPE detection method to improve the quantitative evaluation of RPE status in patients. This paper proposes a spatially-aware, Dense-LinkNet-based regression approach to improve the detection of <italic>in vivo</italic> fluorescent cell patterns, achieving precision, recall, and F1-Score of 93.6 <inline-formula><tex-math notation="LaTeX">$\pm$</tex-math></inline-formula> 4.3%, 81.4 <inline-formula><tex-math notation="LaTeX">$\pm$</tex-math></inline-formula> 9.5%, and 86.7 <inline-formula><tex-math notation="LaTeX">$\pm$</tex-math></inline-formula> 5.7%, respectively. These results demonstrate the utility of incorporating spatial inputs into a deep learning-based regression framework for cell detection.
Thermoregulation in winter-acclimatized common eiders (Somateria mollissima) in air and water

Metabolic heat production, body temperature, and skin temperatures of the back and breast were measured and the thermal conductance, and thus insulation, estimated in winter-acclimatized common eiders (Somateria mollissima) exposed to air and water. When exposed to low air temperatures, the plumage was responsible for most of the insulation. When exposed to water, the insulation in the plumage was reduced. This decrease was, however, compensated through increased peripheral vasoconstriction. A low total thermal conductance lowers the energetic costs of existence in cold environments. This reduces the nutritional demands, and may be an adaptation to living in polar and subpolar regions where temperatures are low and where the short day length during winter may reduce the time available for feeding.
Distribution, growth and mortality of larval jack mackerel Trachurus japonicus in the southern East China Sea in relation to oceanographic conditions

Distribution, growth and mortality of jack mackerel Trachurus japonicus larvae ,10 mm standard length (SL) were investigated in relation to habitat conditions in the southern East China Sea (ECS) in 2005, 2007 and 2009. In all the years, the center of larval distribution shifted northeastward with growth, indicating northeastward entrainment by the Kuroshio branch current. In 2005, the mean habitat temperature of the larvae was 28C lower than the other two years. Mean density of the major prey item Paracalanus spp. in the larval habitat varied interannually, with the highest and lowest values in 2007 and 2005, respectively. The mean absolute growth rate and weight-specific instantaneous growth coefficient (Gw) were highest in 2007 (0.30 mm d 21 and 0.217 d, respectively) and lowest in 2005 (0.19 mm d and 0.120 d, respectively), corresponding with the habitat temperature and food availability. There was no significant interannual difference in the daily instantaneous mortality coefficient (Z) which ranged from 0.107 d in 2009 to 0.136 d in 2007. The ratio Gw/Z, an index of stage-specific larval survival, was highest (1.60) in 2007 and lowest (1.02) in 2005. The lowest Gw/Z in 2005 corresponded with the lowest recruitment of the juveniles (mainly 50–75 mm SL) in the ECS in 2005. However, Gw/Z in 2007 and 2009 did not clearly correspond with recruitment levels, suggesting that a high Gw/Z is a necessary, but may not be a sufficient, criterion of a strong year-class.
Distributed Cooperative Economic Optimization Strategy of a Regional Energy Network Based on Energy Cell–Tissue Architecture

The conventional centralized control method can effectively solve the influence of system power imbalance on the optimal dispatching of a power network and stabilize the power fluctuation of tie lines when the control precision is relatively high. However, when there are disturbances and uncertainties in the system, the robustness is insufficient. The distributed control method in economic optimization scheduling has the advantages of simple communication and high reliability and is well adapted to the energy dispersion characteristics of a distributed generator within the regional energy network. However, the control accuracy is slightly less than that of the centralized control method, and when the distributed power encounters a random input or exit, the corresponding sparse network matrix needs to be updated every time, complicating the use of this system for economic operation. In addition, when message loss or communication noise occurs in the communication path, the robustness of distributed control is greatly reduced. To address these issues, this paper proposes a novel power allocation framework to solve the economic optimization problem of a regional energy network that requires only local information exchange among neighboring energy cells and tissues. Correspondingly, to meet the supply–demand balance, a distributed cooperative approach based on the equal incremental principle is used to impart decentralized autonomy to the whole system. In addition, the concept of virtual consistency variables is introduced to manage topological change caused by power excursions in the energy cell and to implement plug-and-play capabilities. Relative to the conventional collaborative control method, the case studies demonstrate the scalability, plug-and-play capability, and robustness of decentralized autonomous control strategies in terms of communication delay, communication failure, and message loss, among other aspects.
Multi-Grain Rice Diet Decreases Risk of Breast Cancer in Korean Women: Results from the Health Examinees Study

Although a number of studies explain the association between dietary patterns, which take into account that foods are eaten in combination, and breast cancer risk, the findings are inconsistent. We examined the association between dietary patterns and multi-grain rice intake, and the risk of breast cancer in a large-scale prospective cohort study in Korean women. A total of 93,306 women aged 40–69 years from the Health Examinees-Gem (HEXA-G) study (2004 and 2013) were included. We obtained Information on cancer diagnosis via linkage to the Korea Central Cancer Registry. Factor analysis was conducted to obtain dietary patterns, and Cox proportional models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (95% CI) for breast cancer risk. For 494,490 person-years, 359 new cases of breast cancer occurred. We identified three major dietary patterns, that explained 23.9% of the total variance based on daily total food intake (g/day) from 37 food groups: the meat dietary pattern (higher intake of bread and red meat), the white rice dietary pattern (higher intake of white rice and lower intake of multi-grain rice), and the other pattern. Women who had higher white rice dietary pattern scores had a 35% higher risk of breast cancer, than did women with lower white rice dietary pattern scores (multivariable HR 1.35; 95% CI 1.00–1.84 for the highest vs. lowest quartile of the white rice dietary pattern scores, p for trend = 0.0384). We found that women who consumed three or more servings of multi-grain rice per day had 33% lower risk of breast cancer than did those who consumed one or less multi-grain rice serving per day among women under 50 years of age (multivariable HR 0.67; 95% CI 0.45–0.99, p for trend = 0.0204). Our study suggests that a multi-grain rice diet may be associated with lower risk of breast cancer in Korean women.
“It’s Important but, on What Level?”: Healthy Cooking Meanings and Barriers to Healthy Eating among University Students

The negative impact of a sedentary lifestyle and poor diet on health is evident across the lifespan, but particularly during the university period. Usually, the diet of university students is rich in sweetened drinks and processed foods and low in fruits, vegetables and legumes. Although there is an association between maintaining a healthy diet and the frequency of cooking at home, the time currently spent on cooking or learning how to cook is decreasing globally. The main aim of this study was to explore university students’ perceptions about healthy cooking and barriers to eating healthily. A group of 26 students participated in four focus groups. Content analysis was conducted using Atlas.ti v.8. Students perceived cooking healthily as a more complicated and time-consuming process than cooking in general. Individual and environmental factors were the most reported barriers. Costs and time, among others, were the main barriers pointed out by students with regard to healthy eating. This study highlights the need to develop interventions that modify these false perceptions about cooking healthily, and to train students so that they are able to cook healthy meals in a quick, easy, and cost-effective way. Further, specific actions are required in the university setting to minimize access to unhealthy options and to promote those linked to healthy eating.
Smokers’ and Nonsmokers’ Receptivity to Smoke-Free Policies and Pro- and Anti-Policy Messaging in Armenia and Georgia

Garnering support for smoke-free policies is critical for their successful adoption, particularly in countries with high smoking prevalence, such as Armenia and Georgia. In 2018, we surveyed 1456 residents (ages 18–64) of 28 cities in Armenia (n = 705) and Georgia (n = 751). We examined support for cigarette and electronic nicotine delivery systems (ENDS)/heated tobacco product (HTP) smoke-free policies in various locations and persuasiveness of pro- and anti-policy messaging. Participants were an average age of 43.35, 60.5% female, and 27.3% current smokers. Nonsmokers versus smokers indicated greater policy support for cigarette and ENDS/HTP and greater persuasiveness of pro-policy messaging. Armenians versus Georgians generally perceived pro- and anti-policy messaging more persuasive. In multilevel linear regression, sociodemographics (e.g., female) and tobacco use characteristics (e.g., smoking less frequently, higher quitting importance) correlated with more policy support. Greatest policy support was for healthcare, religious, government, and workplace settings; public transport; schools; and vehicles carrying children. Least policy support was for bar/restaurant outdoor areas. The most compelling pro-policy message focused on the right to clean air; the most compelling anti-policy message focused on using nonsmoking sections. Specific settings may present challenges for advancing smoke-free policies. Messaging focusing on individual rights to clean air and health may garner support.
Dynamics of the Honeybee (Apis mellifera) Gut Microbiota Throughout the Overwintering Period in Canada

Microbial symbionts inhabiting the honeybee gut (i.e., gut microbiota) are essential for food digestion, immunity, and gut protection of their host. The taxonomic composition of the gut microbiota is dynamic throughout the honeybee life cycle and the foraging season. However, it remains unclear how drastic changes occurring in winter, such as food shortage and cold weather, impact gut microbiota dynamics. The objective of this study was to characterize the gut microbiota of the honeybee during the overwintering period in a northern temperate climate in Canada. The microbiota of nine honeybee colonies was characterized by metataxonomy of 16S rDNA between September 2017 and June 2018. Overall, the results showed that microbiota taxonomic composition experienced major compositional shifts in fall and spring. From September to November, Enterobacteriaceae decreased, while Neisseriaceae increased. From April to June, Orbaceae increased, whereas Rhizobiaceae nearly disappeared. Bacterial diversity of the gut microbiota decreased drastically before and after overwintering, but it remained stable during winter. We conclude that the honeybee gut microbiota is likely to be impacted by the important meteorological and dietary changes that take place before and after the overwintering period. Laboratory trials are needed to determine how the observed variations affect the honeybee health.