Miracle-dz/UniFAR-FTUs huggingface dataset:
A systematic investigation on the research publications that have used the medical expenditure panel survey (MEPS) data through a bibliometrics approach

This study aimed to examine how Medical Expenditure Panel Survey (MEPS) data have been used to support scientific discoveries in biomedical and health sciences, and provide insight to researchers who are interested in using MEPS regarding collaborations and dissemination of research output. ,A bibliometric approach was used to systematically examine the publications that used MEPS data and were indexed by PubMed and Web of Science (WoS). Microsoft Excel and bibliometric tools (WoS and VOSviewer) were utilized for quantitative and bibliometric network analysis. The measures were investigated on the total number of publications by year, research categories, source journals, other datasets/databases co-used with MEPS, funding sources, collaboration patterns, and research topics. ,A total of 1,953 eligible publications were included in this study with the numbers growing significantly over time. MEPS data were primarily used in healthcare services, public environmental and occupational health research. The journals that published the most papers using MEPS were all in the healthcare research area. Twenty-four other databases were found to be used along with MEPS. Over 3,200 researchers from 1,074 institutions in 25 countries have contributed to the publications. Research funding was supported from federal, private, local, and international agencies. Three clusters of research topics were identified among 235 key terms extracted from titles and abstracts. ,Our results illustrated the broad landscape of the research efforts that MEPS data have supported and substantiated the value of AHRQ's effort of providing MEPS to the public.
Cooperative Caching and Transmission in CoMP-Integrated Cellular Networks Using Reinforcement Learning

Mobile network caching (MNC) and Coordinated MultiPoint (CoMP) joint transmission (JT) techniques are expected to play a significant role in future networks. Yet, when considering caching in a CoMP-integrated network where both single transmission (ST) and JT are permitted, some challenges need to be tackled. In this paper, we propose a cooperative online caching strategy to realize autonomous transmission-aware content caching and updating for video content delivery. Different from existing works, this paper considers practical time-varying user request patterns, and exploits storage-level and transmission-level cooperation to jointly optimize content caching under dynamic user demands for JT and ST. The former helps reduce caching redundancy and the latter helps BSs create CoMP-JT opportunities to improve cell-edge throughput. We formulate the content caching problem to be a Markov decision process (MDP), in which the system reward is defined as the delay reduction after performing a caching action. The goal is to maximize the system reward. Then, we develop a reinforcement learning (RL)-based online learning algorithm to search the optimal caching policy. To overcome the “curse of dimensionality,” the designed RL-based algorithm is extended with linear approximation. The system performance in terms of delay and cache hit rate is evaluated in the simulations, and the results demonstrate the effectiveness of the proposed strategy.
EVALUATION OF A PROGRAM OF PHYSICAL ACTIVITIES ADAPTED TO THE MORPHOLOGICAL, PHYSIOLOGICAL AND BODY COMPOSITION PARAMETERS OF OVERWEIGHT AND OBESE ADOLESCENTS OF THE LUKUNGA SPORTS CLUB OF KINSHASA, DEMOCRATIC REPUBLIC OF CONGO

Objective. To study the effects of regular physical activity on the morphological, physiological and body composition parameters of overweight and obese adolescents. Methods. We conducted an experimental study with30 adolescents divided in two according to their body mass index. The group 1 was composed of overweight subjects with a body mass index between 25-29.9 kg/m 2 , and group 2 obese subjects with a body mass index 30 kg/m 2 subjected to a program of adapted physical activity associated with a low-calorie nutrition education low in cholesterol and in saturated fatty acids (bad fats), low-fat rich in vegetables, fruits and vitamins for a period of six months. Results. This study reveals that after six months of intervention, overweight subjects significantly decreased waist circumference (82.9 ± 4.2 cm before versus 77.6 ± 4.6 cm after), heart rate (86.8 ± 3.6 beat/min before versus 81.4 ± 3.8 beat/min after), total fat (32.2 ± 1.8% before versus 27.2 ± 1.5% after), visceral fat (16.6 ± 2.3% before versus 11.1 ± 2.5% after), and decreased muscle (15.6 ± 2.7% before versus 19.4 ± 4.1% after), while obese subjects significantly decreased waist circumference (88.9 ± 6.2 cm before versus 85.8 ± 5.9 cm after), visceral fat (17.4 ± 3.2% before versus 14.1 ± 3.1% after), respiratory capacity (61.1 ± 2.7% before versus 65 ± 2.1%). In addition this study reveals that overweight subjects compared to obese subjects more changed their waist circumference (77.6 ± 4.6 cm for overweight versus 85.8 ± 5.9 cm for obese), body mass index (24.9 ± 4.1 kg/m 2 for overweight versus 28.8 ± 1.2 kg/m 2 for obese), heart rate (81.4 ± 3.8 beat/min for overweight versus 28.8 ± 1.2 beat/min for obese), visceral fat (11.1 ± 2.5% for overweight versus 14.1 ± 3.1% for obese), and muscle (19.4 ± 4.1% for overweight versus 17.1 ± 2.1%). Conclusion. Obese adolescents have by means of regular activity significantly changed their morphological, physiological and body composition parameters of overweight and obese.
The economic effect of China's educational input, based on the research of dynamic spatial Dubin model

Based on the growth framework of M‐R‐W, this paper uses panel fixed effect and dynamic space Dubin model to analyze the impact of Chinese education investment on economic growth and spatial effects of education investment for 31 province‐level regions in China from 2008 to 2016. The results reveal the following findings: First, the role of education investment in China's economic growth is limited, and the role of education investment in economic growth is quite different in different economic regions. Changes in per capita education investment only have a significant impact on economic growth in the Yangtze River Delta, Northeast China, and Northwest China. Second, when education investment affects economic growth, there is an inverted U‐shaped Kuznets curve. The effect of education investment reflected by human capital on economic growth is lower than that of physical capital. Third, there is a positive spatial agglomeration effect on the spatial distribution of educational investment in various regions of China, but the effect is weak. Fourth, the spatial spillover effect of educational investment is greater than the direct effect. In other words, the economic growth effect of educational investment in a certain region is lower than that of other regions.
APPLYING GATA3 IN DIFFERENTIATING UROTHELIAL CARCINOMA FROM PROSTATIC ADENOCARCINOMA: AN IMMUNOHISTOCHEMICAL STUDY

Objectives: Urothelial carcinoma and prostatic adenocarcinoma are the most common tumors of genitourinary system. Both tumors can demonstrate a broad morphology or present as poorly differentiated carcinoma occurring in urinary bladder or prostate or both organs that raise the suspicion of a locally extending or metastatic carcinoma from either organs. Accurate distinction between these tumors is mandatory because of different tumor biology and therapeutic protocols. In equivocal tumor morphology, the primary option is to use immunohistochemical panel in surgical pathology that includes differentiation markers that will assist pathologists to avoid misdiagnosis. The aim of this study is immunohistochemical evaluation of GATA3 in urothelial carcinoma and prostatic adenocarcinoma with correlation to different clinicopathological parameters.Methods: We used formalin-fixed paraffin-embedded tissue blocks from 51 patients of urothelial carcinoma and 15 patients of prostatic adenocarcinoma including different grades, stages, and types. Monoclonal antibody for GATA3 was used for immunohistochemical staining of tissue sections, and GATA3 expression was semi-quantitatively scored using H-score method.Results: Of 51 urothelial carcinomas, 96% were GATA3 positive with a mean H-score = 212. No correlation between GATA3 expression and clinicopathological parameters includes grade and stage. Lower GATA3 expression was noted in urothelial carcinoma variants. All of prostatic adenocarcinoma cases did not show GATA3 reactivity.Conclusion: GATA3 reactivity is a reliable factor to confirm diagnosis of urothelial carcinoma and exclude prostatic adenocarcinoma. The routine use of GATA3 as differentiation marker for urothelial carcinoma may be advocated based on the results of this study.
Development of a broadly reactive vaccine for highly pathogenic H5N1 influenza

Emerging and re-emerging infectious diseases are increasing throughout the world and highly pathogenic influenza is among those that pose a significant threat to mankind. Pandemic outbreaks of influenza are caused by the emergence of a highly pathogenic and transmissible virus to which the human population is immunologically naive. Ongoing outbreaks of highly pathogenic avian influenza of the H5N1 subtype are of particular concern because of the high mortality rate (>60%) and novel subtype. Vaccines are considered the most effective way to prevent the morbidity and mortality associated with pandemic influenza and therefore developing an H5N1 vaccine is a public health priority. One of the hurdles facing H5N1 vaccine development is the antigenic diversity of the subtype as evidenced by the identification of ten phylogenetic clades. To overcome the challenge of antigenic diversity, a centralized hemagglutinin was developed and termed computationally optimized broadly reactive antigen (COBRA). The COBRA HA sequence was based upon HA amino acid sequences from clade 2 H5N1 human infections and the expressed protein retained the ability to bind the receptor, as well as mediate particle fusion. COBRA virus-like particle (VLP) vaccines elicited broadly reactive receptor blocking antibodies in multiple animal species: mice, ferrets and non-human primates. The reactivity profile was broader than that elicited by primary isolate-based vaccines given in either monovalent or polyvalent formulations. Although all vaccinated animals were protected from severe disease and death from experimental infection with highly pathogenic H5N1 virus, animals receiving the COBRA vaccine had reduced peak virus replication and cleared the infection more rapidly. COBRA vaccines were shown to be superior to primary isolate-based vaccines with both a broader antibody profile and more efficient protective efficacy. The development of COBRA resulted in a novel antigen generation methodology that is applicable to both pandemic and seasonal influenza.
Segmentation of Text-Lines and Words from JPEG Compressed Printed Text Documents Using DCT Coefficients

Segmenting a document image into text-lines and words finds applications in many research areas of DIA (Document Image Analysis) such as OCR, Word Spotting, and document retrieval. However, carrying out segmentation operation directly in the compressed document images is still an unexplored and challenging research area. Since JPEG is most widely accepted compression algorithm, this research paper attempts to segment a JPEG compressed printed text document image into text-lines and words, without fully decompressing the image. During JPEG compression, the non-overlapping 8×8 DCT blocks encode text contents of two adjacent text-lines and words without leaving any visible clue for segmentation. This paper proposes two stage algorithms for segmentation of text-lines and words by intelligently analyzing approximate text-line and word boundaries using the DC coefficient during the first stage. In the second stage, AC coefficients of selected DCT blocks are used to extract exact line and word boundaries. The experimental results on a JPEG compressed document data set (with variable spacing between lines and words, different font sizes and styles) shows a good computational performance.
Functional Interaction of BPV-1 E2 with the Papillomavirus Genome: A Dissertation

The bovine papillomavirus type 1 E2 protein is a multifunctional early viral protein with roles in all phases of the cell cycle. E2 is required during G1 as a transcription factor, in S phase to initiate viral replication and during mitosis to tether the viral genome to dividing DNA. The viral genome contains 17 E2 binding sites, the majority of which are concentrated in the long control region (LCR), a regulatory region that is upstream of the viral coding sequence. The role of these binding sites has been explored in vitro using small plasmids and E1 and E2 proteins expressed in bacteria and insect cells. In this study we attempt to examine the placement of E2 on its binding sites during all phases of the cell cycle and in the context of a stably replicating viral system. As part of the examination of the role of E2 during mitosis, we have also examined the role of the cohesin protein Scc1 in viral tethering. Two groups have published disparate reports identifying the cellular protein that binds to the transactivation domain of E2 to stably maintain viral genomes during cell division. Our group has published that it is the DNA helicase ChlR1 that is required for viral tethering, while it has been reported that it is the bromodomain protein Brd4 that is responsible. In this study we contribute to a report that shows that the cellular protein Scc1 binds to the viral genome through a ChlR1 independent mechanism. The cohesin protein binds to BPV-1 E2 at intermittent stages of the
The role of outer membrane homeostasis in the virulence of gram-negative bacteria

his study investigated the underlying mechanisms of outer membrane homeostasis in Gram-negative bacteria. Using both the evolved laboratory strain E. coli K12 and the broad host range pathogen Salmonella enterica serovar Typhimurium, we have identified and characterised a series of non-essential genes responsible for the maintenance of the outer membrane barrier function. We have revealed their importance for bacterial pathogenesis suggesting their use as novel targets for drug development. This study has provided the first description of a pathway for phospholipid transport from the inner membrane to the outer membrane via the lipoprotein PlpA, a gene previously of unknown function. As several of the genes highlighted by our initial studies were associated with the biogenesis of virulence factors, we complemented our investigations by characterising the contributions of the S. Typhimurium Type V proteins to virulence in a murine model. These investigations have provided the first peer reviewed characterisation of a trimeric autotransporter from Salmonella, has identified a mechanism by which Salmonella can survive on tomatoes, and has highlighted the functional redundancy of these proteins in Salmonella infection. These findings have significantly advanced our understanding of the mechanisms mediating outer membrane homeostasis and the biogenesis and functions of virulence factors.
Expert system for determining the type of cats and how to care them

Cats are one of the many animals kept by animal lovers in Indonesia because the cat is a very friendly animal with humans and has a funny character. Nevertheless, not all cat lovers understand exactly the type of cat that is owned even how to care especially for ras or domestic cats (kucing ras - in Bahasa), because each type of ras cat has different character and way of care. This causes the pet cat affected by various diseases to cause death. One way to overcome the incomprehension of cat lovers in taking care of it is with the help of expert systems that have proven reliability in helping solve problems that require solutions as an expert in his field. This expert system was developed using forward chaining method. By answering any questions asked by the system about the characteristics of the cat owned, users will get answers about the type of cat they have and the way of good and right care.
Facets of Visual Aesthetics of Mobile Website

With the advent of the era of mobile commerce, user browse mobile website on mobile devices is in the majority. The current literature focused on the web aesthetics. However, there is no related visual aesthetics scale for mobile website. Our purpose in this study was to verify the essential characteristics of aesthetics by conceptualizing, constructing, refining, and testing a multiple-item scale, VisMWA, designed to measure aesthetics in the mobile environment. The results showed that five factors and 26 key indicators of VisMWA. The VisMWA scale developed by present study will be able to provide enterprise the standard when they are designing mobile website; and makes it become high-aesthetics mobile website to increase the visitors.
Detection of Mad Lazim Harfi Musyba Images Uses Convolutional Neural Network

Reading of Al Quran is an obligation for all Muslims. Lack of knowledge about the knowledge of recitation in reading the Al Quran is certainly a problem. The purpose of this study makes it easier for everyone to learn the law of recitation, especially Madd Lazim Harfi Musyba in the Al Quran verses. The method used is one of the deep neural network methods, namely Convolutional Neural Network (CNN), as real-time detection of the law of Madd Lazim Harfi Musyba, implementation of the method using the help of Tensorflow GPU (Graphic Processor Unit) library. The results of trials with the Deep Convolutional Neural Network model show the detection performance of 9 verses with an average accuracy of 93.25%. The conclusion is that the training data on the CNN model is very reliable in detecting the Mad lazim harfi musyba law. Therefore this system can be used to assist in applying the Mad Lazim Hafi Musyba legal recitation while reading the Al Quran.
Régulation de l'apoptose par les microARN du virus associé au sarcome de Kaposi

Le virus associe au sarcome de Kaposi (KSHV) code pour un cluster de 12 precurseurs de micro (mi)ARN abondamment exprimes pendant les phases lytiques et latentes de l’infection. Des etudes precedentes ont rapporte que KSHV est capable d’inhiber l’apoptose pendant l’infection latente ; nous avons donc teste si les miARN du virus etaient impliques dans ce processus. Nous avons trouve que des cellules HEK293 et DG-75 exprimant de maniere stable les miARN de KSHV etaient protegees de l’apoptose. Les cibles cellulaires potentielles qui etaient significativement negativement regulees lors de l’expression des miARNs de KSHV ont ete identifiees par analyse transcriptomique par microarray. Parmi celles-ci, nous avons valide par tests rapporteurs luciferase, PCR quantitative, et western blot, Caspase 3 (CASP3), un facteur jouant un role critique dans le controle de l’apoptose. Via le biais de mutagenese dirigee, nous avons montre que trois miARN de KSHV, miR- 12-1, 3 et 4-3p, etaient responsables du ciblage de CASP3. L’inhibition specifique de ces miARN dans des cellules infectees par KSHV a resulte en une augmentation des niveaux d’expression de CASP3 endogene, et en une apoptose plus accrue. Vus dans leur ensemble, nos resultats suggerent que les miARN de KSHV participent directement a l’inhibition precedemment rapportee de l’apoptose par le virus, et donc qu’ils jouent probablement un role dans l’oncogenese induite par KSHV.
Investigations into the use of human embryonal carcinoma stem cells as a model to study dopaminergic neurogenesis

Parkinson's disease in reality arises as a result of a complex series of events, however it is strongly linked to the loss of a specific cellular population of midbrain dopaminergic neurons making it a candidate for stem cell based research. Stem cells can be cultured in vitro and via asymmetric cell division possess the capacity for both self renewal and the production of differentiated derivatives. The use of specific molecules and culture conditions can be applied to promote the differentiation of them towards particular cellular fates, in turn facilitating the possibility of producing enriched populations of cells displaying characteristics of a certain phenotype of interest. There has been much research focussed on the in vitro generation of dopaminergic neurons from various stem cell types. In this work the Tera2.cl. SP12 embryonal carcinoma stem cell line was the primary vehicle investigated for its ability to produce cells that were reflective of a dopaminergic phenotype. Retinoic acid was found to be able to up regulate the expression of a range of dopaminergic markers in the Tera2.cl. SP12 cell line over time. However it was clear that lowered oxygen culture, a method known to promote the production of neurons reflective of a dopaminergic phenotype in mesencephalic cultures, had no effect on the dopaminergic differentiation capacity of the embryonal carcinoma stem cells. The glycoprotein Wnt1 when applied to Tera2.cl. SP12 cultures in concert with retinoic acid was shown to increase the number and percentage of cells positive for the neuronal marker Beta III tubulin approximately 1.5 fold. This was accompanied by a concomitant rise in the mRNA expression of this marker, thus suggesting that the use of Wnt1 may be a means to produce cultures derived from embryonal carcinoma cells that are more neuronal, based on marker expression data. Other established methods to achieve dopaminergic differentiation such as suspension culture, stromal cell co-culture and the application of Sonic hedgehog and Fibroblast growth factor 8 are also able to induce a degree of neuronal and dopaminergic marker expression in Tera2.cl. SPI2 cultures. Overall these results suggest that the Tera2.cl. SP12 cell line might be one vehicle for the study of dopaminergic neurogenesis in vitro, in particular when Wnt1 and retinoic acid are used as a means to favourably enrich the population of cells displaying neuronal characteristics.