Miracle-dz/UniFAR-FTUs huggingface dataset:
Health Related Quality of Life for Young People receiving Dialectical Behaviour Therapy ( DBT )

Purpose: Adults presenting with borderline personality disorder (BPD) score poorly on measures of health related quality of life (HRQoL). Little is known about HRQoL in adolescents with BPD type presentations and how treatment impacts quality of life. Our primary aim was to use routinely collected quality-of-life outcome measures pre and posttreatment in dialectical behaviour therapy (DBT) for adolescents to address this gap. Secondary aims were to benchmark these data against EuroQol 5 dimensions (EQ-5DTM) outcomes for clients treated in clinical trials and to assess the potential of the EQ-5DTM as a benchmarking tool. Method: Four adolescent DBT teams, routinely collecting outcome data using a pseudonymised secure web-based system, supplied data from consecutive discharges. Results: Young people in the DBT programmes (n = 43) had severely impaired HRQoL scores that were lower at programme admission than those reported in published studies using the EQ-5DTM in adults with a BPD diagnosis and in one study of adolescents treated for depression. 40 % of adolescents treated achieved Reliable Clinical Change. HRQoL improved between admission and discharge with a large effect size. These results were not statistically significant when clustering in programme outcomes was accounted for. Conclusion: Young people treated in NHS DBT programmes for BPD type presentations had poorer HRQoL than adults with a BPD diagnosis and adolescents with depression treated in published clinical trials. The EQ-5DTM detected reliable change in this group of adolescents. Programme outcome clustering suggests that both the measure and the web-based monitoring system provide a mechanism for benchmarking clinical programmes.
for stakeholder dialogue : Rich pictures A polyphonic picture book

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ESTIMATION OF GENETIC PARAMETERS R. THOMPSON and N.D. CAMERON, UK

This is a review of various aspects o f estim ation o f genetic parameters, concentrating on developments since the la s t World Congress. Improvements in algorithms to estimate variance and covariance components are described. We discuss the relevance of these procedures, developed fo r unselected populations, when they are applied to se lected populations and ind icate unresolved d i f f ic u lt ie s . We comment on the use o f mixed model methodology to estim ate rea lised h e r ita b il it ie s . We consider the design o f experiments to estimate multivariate parameters. In particular, we. show that fo r b iva r ia te uncorrelated data the variance o f the estimated genetic parameters can be reduced by 0.4 relative to more conventional designs.
Uncovering transcriptional cis-regulatory elements active in adult zebrafish exocrine pancreas

11 Resumo . 13 List of figures . 15 List of tables . 17 List of abbreviations . 18 Introduction. 20 1. Pancreas . 20 1.1 Early pancreas development and morphology.20 1.2. Danio rerio as a model system to study pancreas development and function . 22 1.2.1. Zebrafish development . 22 1.2.2. The zebrafish pancreas . 24 1.3. Pancreatic diseases . 26 2. Gene regulation: general aspects . 27 2.1. The role of cis-regulatory elements in the genome . 28 2.2. Genome-wide techniques to predict cis-regulatory elements . 29 2.2.1. Chromatin epigenetic marks for enhancers and promoters . 31 2.2.2. Accessing open chromatin regions using ATAC-seq to find cisregulatory elements . 34 2.2.3. Contemporary tools to identify chromatin interactions genome-wide 35 2.3. Genetic tools to study cis-regulatory elements in vivo . 36 2.3. 1. Enhancer assays to test for CREs activity . 37 2.3. 2. Genome editing as a tool for loss of function assays . 39 3. Objectives . 41 4. Material and Methods . 42 4.1. Zebrafish stocks, husbandry, breeding and embryo culture . 42 4.2. DNA extraction from zebrafish embryos . 42 4.3. Generation of the plasmids carrying the selected putative enhancer sequences . 43 4.3. 1. PCR amplification of the selected sequences . 43 4.3. 2. Cloning of fragments into pCR8/GW/TOPO vector . 45 4.3. 3. Recombination of the selected sequences into Z48 and ZED vectors . 46 4.3. 4. Purification of the plasmids for injection . 48
Continuing Professional Development : An integrative approach

This paper reports on the design, development, delivery and evaluation of an online continuing professional development (CPD) course in the area of online teaching by three Irish Higher Education Institutes (HEIs). The course was developed in the context of a nationally coordinated effort to promote CPD of those that teach in Higher Education through digital badges. Survey results suggest a very high overall satisfaction rate with the course as a whole, increased levels of knowledge and confidence in relation to teaching online, and also intended transference to practice. While the external motivator of demonstrating engagement through the digital badge arose in the surveys and focus groups, it did not feature particularly strongly. Implications for CPD are discussed in relation to internal and external drivers and motivations around CPD for higher education teachers, and the need for opportunities for participants to interact and engage in the manner reminiscent of a community of practice approach.
THE RELATIONSHIP BETWEEN PLASMA LEVELS OF TESTOSTERONE AND CORTISOL CONCENTRATIONS RATIO AND PSYCHOLOGICAL OVERTRAINING SYMPTOMS IN ELITE FOOTBALL

Overtraining syndrome is a chronic situation that results from long periods of high intensity and volume work without rest periods. The purpose of this study was to determine the relationship between plasma testosterone and cortisol concentrations with psychological overtraining items (by Consensus group on overtraining of the Societe Francaise de Medecine du Sport) in football referees. Thirty football referees (X±SD: age 28.9±4.54 year; height 178.9±6.45cm; weight 77.5±9.23 kg; BMI 22.96±2.14 kg/m; Vo2max 51.21±2.53 ml/kg/min) volunteered for the study during a rest day (24 hours without training). They were asked to complete the overtraining questionnaire contains 54 question requiring answers of "yes" or "no". Then plasma samples were taken at rest and immediately after agame of Isfahan premier league (vision of Asia). The results of data analyses showed that the overtraining score from questionnaire correlates with cortisol concentration on rest day respectively (r=0.71), and testosterone/cortisol ratio (r=-0.42; p<0.05). Result show that the questionnaire may be a useful tool for monitoring and preventing of overtraining syndrome.
On the Use of Issue Tracking Annotations for Improving Developer

Understanding and measuring how teams of developers collaborate on software projects can provide valuable insight into the software development process. Currently, researchers and practitioners measure developer collaboration with social networks constructed from version control logs. Version control change logs, however, do not tell the whole story. The collaborative problem-solving process is also documented in the issue tracking systems that record solutions to failures, feature requests, or other development tasks. We propose two annotations to be used in issue tracking systems: solution originator and solution approver. We annotated which developers were originators or approvers of the solution to 602 issues from the OpenMRS healthcare system. We used these annotations to augment the version control logs and found 47 more contributors to the OpenMRS project than the original 40 found in the version control logs. Using social network analysis, we found that approvers are likely to score high in centrality and hierarchical clustering. Our results indicate that our two issue tracking annotations identify project collaborators that version control logs miss. Thus, issue tracking annotations are an improvement in developer activity metrics that strengthen the connection between what we can measure in the project development artifacts and the team’s collaborative problem-solving process.
MICROTEXTURES OF Fe-Ti OXIDE MINERALS

Ilmenite and magnetite in anorthositic and related rocks (South-Rogaland igneous complex S.W. Norway) are investigated from the point of view of their microtextures. The microtextures of the ilmenite result from simple exsolution of ilmenite-hematite solid solutions. Hematite lenses appear when the hematite content is higher than 7 to 9 mole percent Hem. Magnetite contains intergrowths of ilmenite according to two extreme types of microtexture : the cloth microtexture and the trellis microtexture (including its sandwich variant). Both types may coexist in the same grain. This ilmenite is formed by oxidation of ulviispinel, initially contained in the magnetite, at temperatures above or below the solvus magnetite-ulviispinel. Arguments leading to rejection of the y-FeTi0 3-Fe30 4 solid solution hypothesis are given. Primary ilmenite adjacent to a magnetite grain shows a zonal variation of hematite (*) Communication presentee a la seance du 7 juillet 1970. Manuscrit depose en seance. (**) Universite de Liege, Laboratoire de Geologie, Petrologie et Geochimie, 7, place du XX Aof1t, 4000 Liege.
On commutativity based edge lean search

Exploring a graph through search is one of the most basic building blocks of various applications. In a setting with a huge state space, such as in testing and verification, optimizing the search may be crucial. We consider the problem of visiting all states in a graph where edges are generated by actions and the (reachable) states are not known in advance. Some of the actions may commute, i.e., they result in the same state for every order in which they are taken (this is the case when the actions are performed independently by different processes). We show how to use commutativity to achieve full coverage of the states while traversing considerably fewer edges.
Characterization of genes coding phenylalanine ammonia lyase and chalcone synthase in four Pogostemon cablin cultivars

Pogostemon cablin (Blanco) Benth is a medicinal plant rich in terpenoids and flavonoids. Currently, the molecular mechanism of flavonoid biosynthesis in P. cablin remains unclear. In this study, three copies of the phenylalanine ammonia lyase (PAL) gene designated as PcPAL1 PcPAL3, one copy of the chalcone synthase (CHS) gene referred to as PcCHS, and four copies of the CHS-like gene referred to as PcCHSL1 PcCHSL4 were isolated from P. cablin. PcPAL1, PcPAL2, and PcPAL3 comprised 2 136, 2 136, and 2 148 bp full-length open reading frames (ORFs) encoding 711, 711, and 715 amino acids, respectively. PcCHS, PcCHSL1, PcCHSL2, PcCHSL3, and PcCHSL4 contained 1 173, 1 176, 1 179, 1 173, and 1 170 bp ORFs encoding 390, 391, 392, 390, and 389 amino acids, respectively. A phylogenetic analysis indicates that PcPAL2 was closer to PcPAL3 than PcPAL1, and that PcCHS was clustered with other plant CHS genes but independently to the PcCHSLs subgroup. A sequence analysis shows that PcCHSLs diverged in functional residues when compared to plant CHSs including PcCHS, suggesting that PcCHSLs may be divergent in tertiary structures. A quantitative reverse-transcription polymerase chain reaction analysis indicates that the expression profiles of PcPALs, PcCHS, and PcCHSLs in leaves and stems differed among four cultivars. Our results suggest that divergence in sequence and expression profiles of the tested genes may contribute to the diversity in flavonoids among the four cultivars. Additional key words: CHS, CHS-like, flavonoids, PAL, phylogenetic tree.
A Comparative Performance Analysis and Flicker Assessment of SCIG and DFIG-Based Wind Turbines

ABSTRACT This paper presents a comparative performance analysis of squirrel cage induction generator (SCIG) and doubly fed induction generator (DFIG) systems driven by wind turbines under different operating conditions. Also, the constant and variable-speed configurations are compared regarding short-term flicker severity, Pst. The constant speed configurations are based on SCIG in addition to SCIG equipped with static synchronous compensator (STATCOM) with the same generation capacity. In this paper, comprehensive models of wind turbine are used to analyze power and voltage fluctuations. The short-time flicker index is used to assess the emitted voltage fluctuation. The effects of grid short circuit capacity and impedance angle on flicker emission are investigated. The influences of site mean-wind-speed and turbulence intensity on voltage fluctuation are also examined. A flickermeter model is implemented according to the guidelines provided by IEC 61000-4-15 to evaluate the severity of voltage fluctuation emission. The models of different system components along with their control schemes are simulated using Matlab/Simulink® package.
Discrete scattering and simple non-simple face-homogeneous random walks

In this paper we will derive some results for characterising the almost closed sets of a face-homogeneous random walk. We will present a conjecture on the relation between discrete scattering of the fluid limit and the absence of non-atomic almost closed sets. We will illustrate the conjecture with random walks with both simple and non-simple decomposition into almost closed sets.
THE PURDUE UNIVERSITY GRADUATE SCHOOL STATEMENT OF COMMITTEE APPROVAL

Mirzaeibonehkhater, Marzieh. M.S.E.C. E. , Purdue University, August 2018. Developing a Dynamic Recommendation System for Personalizing Educational Content within an E-Learning Network. Major Professors: Brian King and Ali Jafari. This research proposed a dynamic recommendation system for a social learning environment entitled CourseNetworking (CN). The CN provides an opportunity for the users to satisfy their academic requirement in which they receive the most relevant and updated content. In our research, we extracted some implicit and explicit features from the system, which are the most relevant user feature and posts features. The selected features are used to make a rating scale between users and posts so that represent the link between user and post in this learning management system (LMS). We developed an algorithm which measure the link between each user and post for the individual. To achieve our goal in our system design, we applied natural language processing technique (NLP) for text analysis and applied various classification technique with the aim of feature selection. We believe that considering content of the posts in learning environments as an impactful feature will greatly affect to the performance of our system. Our experimental results demonstrated that our recommender system predict the most informative and relevant posts to the users. Our system design addressed the sparsity and cold-start problems, which are the two main challenging issues in recommender systems.
Introducing two isolates of Bdellovibrio from Iran-Rafsanjan

Bdellovibrio bacteriovorus is an obligate predator of other Gram-negative bacteria. It grows in the periplasm of the prey cell and finally lyses them, so it has high potentials to be used in biocontrol of plant pathogenic bacteria. The objective of the present study was to isolate and characterize Bdellovibrios bacteria from soil and water samples of Rafsanjan, Kerman province, Iran. To do this, after sampling, two Bdellovibrios isolates (Sar and Pj) were isolated by using Escherichia coli strain K12 as prey on the two layer agar. The isolates were identified by phenotypic and 16S rDNA sequencing. The sequencing and phylogenetic studies showed that the strains have more than 99% similarity to B. bacteriovorus. Then, the host range and specificity of the strain were evaluated on 9 different Gram negative bacterial species. The results showed that the strains have predatory effects only on E. coli as prey and do not have any effect on Pseudomonas
IMPACT OF OBESITYAND NITRIC OXIDE SYNTHASE GENE G894TPOLYMORPHISM ON ESSENTIALHYPERTENSION

Essential hypertension (EH) is one of the most common diseases af fecting humans worldwide and a major risk factor for cardiovascular diseases, including stroke, myocardial infarction, heart failure and coronary artery disease (1). It has been recognized that number of patients with essential hypertension is increasing, however , the reason for this increase remained uncertain (2). Hypertension is thought to be a multifactorial disease caused by environmental, metabolic and genetic determinants (3). However , little is currently known on the complex interplay between genetic, environmental and metabolic factors and its implication for healthcare. A rising prevalence of overweight and obesity is evident in men and women, and obesity has been recognized as a major public health problem (4, 5). Obesity is associated with a high prevalence of hypertension (6, 7). However , not all obese individuals are hypertensive, indicating that there is a considerable variation in responses to metabolic dysregulation. It can be hypothesized that interaction between obesity and genetic factors involved in the regulatory pathways of blood pressure plays a significant role in hypertension development in obese individuals. Obesity is a condition of increased adipose tissue mass. Human adipose tissue expresses all components of the renin/angiotensin system(RAS), including angiotensinogen, angiotensin-converting enzyme (ACE) as well as AT1 (angiotensin type 1), and AT2 (angiotensin type 2) receptors (6, 8, 9). Moreover , there is evidence that obesity is associated with endothelial cell dysfunction (10, 1 1), unbalanced circulating levels of nitric oxide (NO) metabolites due to increased oxidative stress (12), and decreased NO production (13). NO is a key paracrine regulator of vascular homeostasis and NO bioavailability is determined by a balance between NO biosynthesis by endothelial JOURNALOF PHYSIOLOGYAND PHARMACOLOGY 2015, 66, 5, 681-689
In this manuscript, titled "Skill assessment of global, regional and coastal circulation forecast models: evaluating the benefits of dynamical downscaling in IBI surface

forecast models: evaluating the benefits of dynamical downscaling in IBI surface waters", the authors describe an inter-comparison of different oceanographic operational systems in the Iberian shelf and in the Gibraltar Strait. Although the numerical results are deeply investigated showing the different model performance in reproducing Surface water properties, to my opinion the manuscript suffers from a lack of identification of the novel aspects of the research. Al stated by the authors, the three considered operational systems have been already described in many publications. Similarly, the benefits of downscaling (i.e. increasing resolution) in coastal waters have been widely treated in literature.
The complete chloroplast genome of the Jerusalem 3 artichoke ( Helianthus tuberosus L . ) and an adaptive 4 evolutionary analysis of the ycf 2 gene 5 6

1 Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Qinghai Key Laboratory of Qinghai-Tibet Plateau Biological Resources, Xining, Qinghai, China 2 Agriculture and Forestry Sciences of Qinghai University, Qinghai Key Laboratory of Vegetable Genetics and Physiology, Xining, Qinghai, China 3 Qinghai University, The Open Project of State Key Laboratory of Plateau Ecology and Agriculture, Xining, Qinghai, China
Understanding KIBS through their Differentiated Knowledge Bases : Applying and Extending a Conceptual Framework

The focus of our research is knowledge intensive business services and particularly similarities and differences among these, at the levels of firms and industries. Knowledge has long held a central place in innovation studies, and in recent years Asheim and colleagues have developed a conceptualisation based on three different ? knowledge-bases’, which go beyond the established distinction between ? tacit’ and ? codified’ knowledge. Very few studies have however either applied this conceptualisation at the firm level, or asked whether other ? types of knowledge’ exist and can be identified. This paper addresses this by identifying a hitherto unrecognised ? knowledge base’: compliance knowledge. By bringing together the literature on KIBS and the literature on ? knowledge bases’, this paper claims to make two contributions. First, it develops a novel conceptual understanding of KIBS firms through their differentiated knowledge bases. Second, it develops the conceptualisation of knowledge bases, particularly through the identification of a hitherto unrecognised ? knowledge base’: compliance knowledge. Understanding KIBS through their Differentiated Knowledge Bases: Applying and Extending a Conceptual Framework
Illness Perception , Level of Education and Presence of Cardiovascular Disease among Patients with Familial Hypercholesterolaemia

Illness perception determines the healthy lifestyle of patients with Familial Hypercholesterolaemia (FH). Despite the availability of advanced treatment and preventive measures, there is still sparse data on illness perception of FH patients. Hence, this study aimed to describe the illness perception of FH patients and investigate its association with sociodemographic and illness-related factors. 100 FH patients were assessed using Pro forma questionnaires and revised illness perception questionnaire (IPQ-R). Illness perception of FH patients varies according to the level of education and the presence of cardiovascular disease (CVD). These findings may help clinicians to improve the interventions suitable for FH patients.
Search for B 0 s → γγ and a measurement of the branching fraction for B 0 s → φγ

D. Dutta, B. Bhuyan, A. Abdesselam, I. Adachi, H. Aihara, S. Al Said, K. Arinstein, D. M. Asner, V. Aulchenko, T. Aushev, R. Ayad, T. Aziz, S. Bahinipati, A. M. Bakich, V. Bansal, V. Bhardwaj, A. Bobrov, G. Bonvicini, M. Bračko, T. E. Browder, D. Červenkov, A. Chen, B. G. Cheon, K. Chilikin, R. Chistov, K. Cho, V. Chobanova, Y. Choi, D. Cinabro, J. Dalseno, Z. Doležal, Z. Drásal, A. Drutskoy, K. Dutta, S. Eidelman, H. Farhat, J. E. Fast, O. Frost, V. Gaur, S. Ganguly, A. Garmash, D. Getzkow, Y. M. Goh, B. Golob, H. Hayashii, X. H. He, W. -S. Hou, T. Iijima, A. Ishikawa, Y. Iwasaki, I. Jaegle, D. Joffe, K. H. Kang, E. Kato, C. Kiesling, D. Y. Kim, J. B. Kim, J. H. Kim, K. T. Kim, M. J. Kim, S. H. Kim, Y. J. Kim, K. Kinoshita, B. R. Ko, P. Kodyš, S. Korpar, P. Križan, P. Krokovny, T. Kuhr, A. Kuzmin, Y. -J. Kwon, J. S. Lange, I. S. Lee, P. Lewis, Y. Li, L. Li Gioi, J. Libby, D. Liventsev, D. Matvienko, H. Miyata, R. Mizuk, G. B. Mohanty, A. Moll, T. Mori, R. Mussa, E. Nakano, M. Nakao, T. Nanut, M. Nayak, N. K. Nisar, S. Nishida, S. Ogawa, S. Okuno, P. Pakhlov, G. Pakhlova, T. K. Pedlar, R. Pestotnik, M. Petrič, L. E. Piilonen, E. Ribežl, M. Ritter, A. Rostomyan, Y. Sakai, S. Sandilya, L. Santelj, T. Sanuki, Y. Sato, V. Savinov, O. Schneider, G. Schnell, C. Schwanda, A. J. Schwartz, D. Semmler, V. Shebalin, T. -A. Shibata, J.-G. Shiu, B. Shwartz, A. Sibidanov, F. Simon, Y. -S. Sohn, A. Sokolov, E. Solovieva, M. Starič, M. Sumihama, T. Sumiyoshi, Y. Teramoto, K. Trabelsi, M. Uchida, Y. Unno, S. Uno, Y. Usov, C. Van Hulse, P. Vanhoefer, G. Varner, A. Vinokurova, A. Vossen, M. N. Wagner, C. H. Wang, P. Wang, Y. Watanabe, S. Wehle, K. M. Williams, E. Won, H. Yamamoto, J. Yamaoka, S. Yashchenko, Y. Yusa, Z. P. Zhang, V. Zhilich, and A. Zupanc