Miracle-dz/UniFAR-FTUs huggingface dataset:
Uppsala Center for Fiscal Studies

This paper develops a Mirrlees (1971) framework with heterogeneous agents to analyze optimal redistributive taxes, optimal provision of public goods and the marginal cost of public funds (MCF). Standard MCF measures are shown to suﬀer from three defects: i) The MCF for the (non-individualized) lump-sum tax is generally not equal to one. ii) The MCF for distortionary taxes is not directly related to the marginal excess burden. iii) MCF measures for both lump-sum and distortionary taxes are highly sensitive to the choice of the untaxed numéraire good. These problems are caused by using the private rather than the social marginal value of private income to calculate the MCF, and disappear by using the social marginal value of private income. Moreover, by allowing for redistributional concerns, the marginal excess burden of distortionary taxes equals the marginal distributional gain at the optimal tax system. MCF therefore equals one, both for lump-sum and distortionary taxes, and the modiﬁed Samuelson rule should not be corrected for the marginal cost of public funds.
Monthly cholecalciferol administration in haemodialysis patients: a simple and efficient strategy for vitamin D supplementation

Background. There is growing evidence of the usefulness of vitamin D supplementation in dialysis patients who are most often vitamin D deficient. Due to the long half-life of vitamin D, there is much interest in administering it intermittently for long-term adherence. However, there are no data to indicate which dosage would be most efficient. Objective. The aim was to assess the long-term efficiency and safety of a monthly oral dose of cholecalciferol (100 000 IU) in vitamin D-deficient haemodialysis (HD) patients. Methods. HD patients with a serum 25-hydroxyvitamin D (25(OH)D) level < 75 nmol/L were enrolled in a 15-month prospective study. The exclusion criteria were as follows: use of any vitamin D derivatives, prescription of cinacalcet and bisphosphonates, uncontrolled hypercalcaemia ( > 2.55 mmol/L), hyperphosphataemia ( > 2 mmol/L) and severe secondary hyperparathyroidism (SHPT; serum study and led to optimal compliance. The most evident consequences were a slight decrease in the levels of PTH and bone markers and an increase in the level of serum 1,25(OH) 2 D. Abstract Background. It is not known if the adjustment of antihypertensive therapy based on home blood pressure monitoring (HBPM) can improve blood pressure (BP) control among haemodialysis patients. Methods. This is an open randomized clinical trial. Hyper-tensive patients on haemodialysis were randomized to have the antihypertensive therapy adjusted based on predialysis BP measurements or HBPM. Before and after 6 months of follow-up, patients were submitted to ambulatory blood pressure monitoring (ABPM) for 24 h, HBPM during 1 week and echocardiogram. Results. A total of 34 and 31 patients completed the study in the HBPM and predialysis BP groups, respectively. At the end of study, the systolic (SBP) and diastolic (DBP) blood pressure during the interdialytic period measured by ABPM were significantly lower in the HBPM group in relation to the predialysis BP group (mean 24-h BP: 135 ± 12 mmHg/76 ± 7 mmHg versus 147 ± 15 mmHg/79 ± 8 mmHg; P < 0.05). In the HBPM analysis, the HBPM group showed a significant reduction only in SBP compared to the predialysis BP group (weekly mean: 144 ± 21 mmHg versus 154 ± 22 mmHg; P < 0.05). There were no differences between the HBPM and predialysis BP groups in relation to the left ventricular mass index at the end of the study (108 ± 35 g/m 2 versus 110 ± 33 g/m 2 ; P > 0.05). Conclusions. Decision making based on HBPM among haemodialysis patients has led to a better BP control during the interdialytic period in comparison with predialysis BP measurements. HBPM may be a useful adjuvant instrument for blood pressure control among haemodialysis patients.
Factors that Influence MSME Performance Improvement (Study on MSMEs of Women Entrepreneurs in Banyumas Regency)

: The aim of this study is analysing factors influencing on the MSMEs Performance Improvement of the Female Entrepreneurship in Banyumas Regency. This study use quantitative method with regression model. Samples consist of 75 persons of MSMEs with the owner or manager as respondents, data gathered by using questionnaire instrument. Base on regression analysis, showed that funding, financial literation and business scale are significantly influence to increasing MSMEs performance, of the Female Entrepreneur in Banyumas Regency. Three other variables, namely: HR competence, entrepreneurial orientation and cost control do not affect the increase in MSME performance. MSME performance can be improved by staying focused on the financial aspects: funding, financial literacy and business size. Other business improvement can be pursued by enhancing HR competencies through training programs and applying entrepreneurial orientation in their business. Female entrepreneurs as owners and MSME entrepreneurs are also very important to control costs as an internal factor that can be controlled.
Calcification and Disease-Related Mortality.

Objective —Arterial calcification is highly correlated with underlying atherosclerosis. Arterial calcification of the thoracic aorta is evident in many older individuals at high susceptibility to aging-related diseases and non-cardiovascular disease (CVD)–related mortality. In this study, we evaluated the association of thoracic aorta calcification (TAC) with non-CVD morbidity and mortality. data from participants in the Multi-Ethnic Study of Atherosclerosis, a prospective cohort study of subclinical atherosclerosis, in which participants underwent cardiac computed tomography at baseline and were followed longitudinally for incident CVD events and non-CVD events. Using modified proportional hazards models accounting for the competing risk of CVD death and controlling for demographics, CVD risk factors, coronary artery calcium, and CVD events, we evaluated whether TAC was independently associated with non-CVD morbidity and mortality. Among 6765 participants (mean age, 62 years), 704 non-CVD deaths occurred for a median follow-up of 12.2 years. Compared with no TAC, the highest tertile of TAC volume was associated with a higher risk of non-CVD mortality (hazard ratio, 1.56; 95% confidence interval, 1.23–1.97), as well as several non-CVD diagnoses, including hip fracture (2.14; 1.03–4.46), chronic obstructive pulmonary disease (2.06; 1.29–3.29), and pneumonia (1.79; 1.30–2.45), with magnitudes of association that were larger than for those of coronary artery calcium. Conclusions —TAC is associated with non-CVD morbidity and non-CVD mortality, potentially through a pathway that is unrelated to atherosclerosis. TAC may be a general marker of biological aging and an indicator of increased risk of non-CVD and death. ( Arterioscler Thromb Vasc Biol . 2018;38:00-00. DOI: 10.1161/ATVBAHA.118.310850.) calcification through a parallel pathway. Although atherosclerosis leads to CVD events, biological aging may lead to an increased susceptibility to non-CVD events (eg, cancer), leading to non-CVD–related mortality. Aging is also a risk factor for atherosclerosis, which in turn leads to CVD events that can also increase an individual’s susceptibility to non-CVD mortality (eg, heightened cancer mortality among individuals with a history of clinical CVD). HDL cholesterol, systolic blood pressure, hypertension medication, smoking, diabetes mellitus, statin medication, body mass index, and C-reactive protein. Nonfatal CVD events were defined as incident coronary heart disease (CHD) events (definite and probable myocardial infarction, resuscitated cardiac arrest, and definite angina) and stroke (nonfatal). CAC indicates coronary artery calcium; CVD, cardiovascular disease; HDL, high-density lipoprotein; and TAC, thoracic aorta calcium. diagnosis or non-fatal CVD event. Non-CVD morbidity diagnoses were abstracted from inpatient medical records via ICD-9 codes. Nonfatal CVD events were adjudicated by physician committee and defined as incident coronary heart disease (CHD) events (definite and probable myocardial infarction, resuscitated cardiac arrest, and definite angina) and stroke.
TE20 mode substrate integrated waveguide based high gain eight‐beam leaky‐wave antenna for multi‐directional radiation coverage

In this article, a TE20 mode substrate integrated waveguide (SIW) is utilized to design a leaky‐wave antenna (LWA) which is capable to scan all the four directions (eight quadrants) simultaneously. With the eight radiated main beams, frequency beam scanning range of the proposed antenna is 56° in all the eight quadrants. By exploiting co‐axial probe feeding and step impedance transformer, four ways microstrip power divider is designed which is further exploited to feed all the four TE20 mode SIW sections containing microstrip‐coupled slotline‐SIW transitions. For radiation, ±45° rectangular slots are systematically placed on the top as well as bottom plane of the structure. The proposed antenna is working within the frequency range of 10‐11.7 GHz having the maximum peak gain of 14 dBi. The proposed design is verified by experimental results which are in good agreement with the simulation. Along with the utilization of higher order mode of SIW to achieve compactness and design simplicity, the four directional frequency beam scanning capability makes it a promising candidate in various microwave circuits and several beam‐scanning applications including navigational and surveillance purpose.
Agile Requirements Engineering

—The Agile Software Development Methodology is fast becoming the more popular and eagerly embraced software development methodology. It is underpinned by the Agile Manifesto which clearly articulates the methodology’s underlying principles and values. Requirements engineering is a key component of any development life cycle, yet it has gained little attention in the studies conducted in the Agile Movement. This paper aims to introduce the key features of requirements engineering in an agile setting and how requirements engineering is carried out in two of the more popular agile methods Scrum and Extreme Programming.
The compliance of our practice of hepatitis B virus screening with the current guidelines in patients undergoing chemotherapy for hematological malignancies

Corresponding Author Funda Pepedil Tanrikulu University of Health Sciences, Adana City Education and Research Hospital, Clinics of Internal Medicine-Hematology, Adana, Turkey E-mail: pepefunda@yahoo.com � Ethics Committee Approval This study was approved by ‘Non-Invasive Research Ethics Committee of Cukurova University Medical Faculty’ on November 6, 2020 (document number 105/66). All procedures in this study involving human participants were performed in accordance with the 1964 Helsinki Declaration and its later amendments. � Conflict of Interest No conflict of interest was declared by the authors. � Financial Disclosure The authors declared that this study has received no financial support. � Published 2021 November 15
REFLECTIONS, SUCCESSES AND PITFALLS OF COORDINATING ONLINE DISCUSSION FORUMS IN A FOREIGN LANGUAGE

The advent of e-learning has seen the adaptation and use of a plethora of educational techniques. Of these, online discussion forums have met with success and been used widely in both undergraduate and postgraduate education. The authors of this paper, having previously used online discussion forums in the postgraduate arena with success, adopted this approach for the design and subsequent delivery of a learning and teaching subject. This learning and teaching subject, however, was part of an international collaboration and designed for nurse academics in another country – Vietnam. With the nursing curriculum in Vietnam currently moving to adopt a competency based approach, two learning and teaching subjects were designed by an Australian university for Vietnamese nurse academics. Subject materials constituted a DVD which arrived by post and access to an online platform. Assessment for the subject included (but was not limited to) mandatory participation in online discussion with the other nurse academics enrolled in the subject. The purpose behind the online discussion was to generate discourse between the Vietnamese nurse academics located across Vietnam. Consequently the online discussions occurred in both Vietnamese and English; the Australian academic moderating the discussion did so in Australia with a Vietnamese translator. For the Australian University delivering this subject the difference between this and past online discussions were twofold: delivery was in a foreign language; and the teaching experience of the Vietnamese nurse teachers was mixed and frequently very limited. This paper will provide a discussion addressing the design of an online learning environment for foreign correspondents, the resources and translation required to maximise the success of the online discussion, the lessons learnt and consequent changes made, as well as the rationale of delivering complex content in a foreign language. While specifically addressing the first iteration of the first learning module designed, this paper will also address subsequent changes made for the second iteration of the first module and comment on their success. While a translator is clearly a key component of success, the elements of simplicity and clarity in hand with supportive online moderation must not be overlooked.
Binding of l25l-Labeled Recombinant Interferon (IFN-3 Ser17) to Human Cells

We investigated the binding of 12'I-labeled I8 interferon (IFN-I Ser17), a nonglycosylated recombinant human fibroblast interferon in which cysteine at position 17 is replaced by serine by site-specific mutagenesis. An optimized chloramine T radiolabeling method produced a highly labeled, fully active 12'I-IFN suitable for these studies. Unlike the case with the chloramine T method, incorporation of a single mole of Bolton-Hunter reagent into a mole of IFN-, Ser17 led to nearly complete loss of biological activity. 125I-FN-j Ser17, prepared by the chloramine T method, bound specificaOly to human lymphoblastoid cells (Daudi) with a dissociation constant of 0.24 nM. The number of binding sites per cell was 4,000. In competition assays, unlabeled interferons (native, recombinant IFN-,1 Cys,7, and various preparations of IFN-(3 Ser17) equally displaced labeled IFN-, Ser17 on Daudi cells. Recombinant IFN-a-1 displaced 125I-IFN-j binding to Daudi ceOls less efficiently than did unlabeled native or recombinant interferon. However, at the concentrations tested, native 'y interferon showed no competition with '25I-IFN. Our results indicate that IFN-,I Ser17 and native IFN-, posses similar binding properties.
Point‐Pattern Synthesis using Gabor and Random Filters

Point pattern synthesis requires capturing both local and non‐local correlations from a given exemplar. Recent works employ deep hierarchical representations from VGG‐19 [SZ15] convolutional network to capture the features for both point‐pattern and texture synthesis. In this work, we develop a simplified optimization pipeline that uses more traditional Gabor transform‐based features. These features when convolved with simple random filters gives highly expressive feature maps. The resulting framework requires significantly less feature maps compared to VGG‐19‐based methods [TLH19; RGF∗20], better captures both the local and non‐local structures, does not require any specific data set training and can easily extend to handle multi‐class and multi‐attribute point patterns, e.g., disk and other element distributions. To validate our pipeline, we perform qualitative and quantitative analysis on a large variety of point patterns to demonstrate the effectiveness of our approach. Finally, to better understand the impact of random filters, we include a spectral analysis using filters with different frequency bandwidths.
Towards Monolithically Integrated GaAs on Si Tandem Solar Cell

GaAs and Si solar cells are the technologies that achieve the highest single-junction efficiencies. Due to the nonideal bandgap combination, incorporating those two materials into a monolithic integrated tandem is, however, not straightforward. In this paper, we discuss the potential of GaAs/GaAs/Si triple-junction architecture. As the reachable short-circuit current in a GaAs solar cell is about two thirds of that reachable with Si, current matching can be achieved by combining a double-junction GaAs/GaAs top cell with a Si bottom cell. As the first result, we fabricated a prototype of GaAs/GaAs dual-junction top cell with an efficiency of 17.8% and demonstrated a four-terminal tandem solar cell with an efficiency of 20.4%. However, with state-of-the-art material properties, the integrated GaAs/GaAs/Si concept is envisioned to reach a standard-testing-condition efficiency of 33.0% under AM1.5G.
Endoplasmic Reticulum Homeostasis in Huntington’s Disease

Huntington’s disease (HD) is a neurodegenerative pathology associated with an increased number of polyglutamine repeats (polyQ) within the mutant huntingtin protein (mHtt). Expanded polyQ repeats increase the propensity of the mHtt protein to form aggregates, resulting in the subsequent formation of larger, insoluble, amyloid-like aggregates termed inclusion bodies. Over the years several studies have identified perturbation of endoplasmic reticulum homeostasis (ER stress) as a determinant of polyQ toxicity in various HD models, from yeast cells to patient post-mortem samples. Importantly, targeting ER stress in experimental models of HD has resulted in increased neuronal cell viability both in vitro and in vivo . Here, we discuss the recent advances in the field that link ER stress signaling pathways to mHtt aggregation and toxicity.
Inter Cross-Resistance Determines Treatment Sequence Therapies in Advanced Prostate Cancer

Current treatments for castration resistant prostate cancer (CRPC) largely fall into two classes; AR-targeted therapies such as the next-generation anti-androgen therapies (NGATs), enzalutamide and abiraterone, and taxanes, docetaxel and cabazitaxel. Despite improvements in outcomes, patients still succumb to the disease due to the development of resistance. Further complicating the situation is lack of a well-defined treatment sequence and potential for cross-resistance between therapies. We have developed several models representing CRPC with acquired therapeutic resistance. Here, we utilized these models to assess putative cross-resistance between treatments. We find that resistance to enzalutamide induces resistance to abiraterone and vice versa but resistance to neither alters sensitivity to taxanes. Acquired resistance to docetaxel induces cross-resistance to cabazitaxel but not to enzalutamide or abiraterone. Correlating responses with known mechanisms of resistance indicates that androgen receptor (AR) variants are associated with resistance to NGATs while the membrane efflux protein ABCB1 is associated with taxane resistance. Mechanistic studies show that AR variant-7 (AR-v7) is involved in NGAT resistance but not resistance to taxanes. Our findings suggest the existence of intra cross-resistance within a drug class (i.e., within NGATs or within taxanes), while inter cross-resistance between drug classes does not develop. Furthermore, our data suggests resistance mechanisms differ between drug classes. These results may have clinical implications by showing that treatments of one class can be sequenced with those of another, but caution should be taken when sequencing similar classed drugs. Additionally, the development and use of biomarkers indicating resistance will improve patient stratification for treatment. in prostate cancer Our data suggest that AR-variants expression is associated with resistance to NGATs but not with taxane resistance, while ABCB1 is associated with robust resistance to taxanes. taxanes. An additional clinical study supporting our work showed that AR-v7 status appears not to predict response to cabazitaxel Thus, our work supports the use of AR-variants to stratify patients between NGATs and taxanes. correlates with taxane resistance. A. Western blots for expression of AR and ABCB1 were performed in C4-2B, MDVR, AbiR, and TaxR whole cell lysates. Tubulin served as a loading control. B. C4-2-NEO and C4-2-ARv7 cells were subjected to cell growth assays testing dose response to either docetaxel or cabazitaxel. Western blot was used to show that C4-2-ARv7
Facts from the Early Years of the History of Combinatorial Chemistry

Looking into the combinatorial chemistry literature one can see that it is still mostly believed that the first combinatorial synthesis was invented by several groups exactly at the same time. In fact the principles of combinatorial chemistry, that is, synthesis of large number, even millions, of compounds and then by applying a proper deconvolution method identify the useful components, was invented, first described and notarized as early as 1982 by the Author of this article. The first publication of the synthetic method was in 1988. In February 1990 the manuscript of an article also describing the combinatorial split-mix synthesis was submitted to the International Journal of Peptide and Protein Research that appeared after a one and a half year delay. In this period four patent applications were filed, two conference lectures, two Nature papers and a book chapter were submitted then published. The editor in chief of the mentioned journal was among the authors of one patent application, one lecture, one Nature article and a book chapter. The evidences described below will hopefully convince the readers that the inventions in the patent submissions and in the mentioned publications were all 2-3 years earlier described in our 1988 publications and these publications were known by the authors.
Using PPG Signals and Wearable Devices for Atrial Fibrillation Screening

Cardiovascular diseases are the primary cause of deaths in the world. Atrial fibrillation (AF) is the most common type of cardiac arrhythmia. Due to its high prevalence and associated risks, early detection of AF is an important objective for healthcare systems worldwide. The growing demand for medical assistance implies increased expenses, which could be limited by implementing ambulatory monitoring techniques based on wearable devices, thus, reducing the number of people requiring observation in hospitals. One of the main challenges in this context is related to the large amount of data from patients to be analyzed, which points to the suitability of using computational intelligence techniques for it. The selection of the features to be extracted from data plays a key role in order for any classifier of heart rhythm to provide good results in this regard. This paper demonstrates that it is possible to achieve an accurate detection of AF using a very low number of relatively simple features extracted from photoplethysmographic signals, enabling the use of affordable wearable devices (with scarce processing and data storage resources) with this purpose over long periods of time. This fact has been validated in experiments using data from real patients under medical supervision.
Re] Explaining Groups of Points in Low-Dimensional Representations

This report covers our reproduction of the paper ʼExplaining Low dimensional Representationʼ [1] by Plumb et al. In this paper, a method (Transitive Global Translations, TGT) is proposed for explaining different clusters in low dimensional representations of high dimensional data. They show their method outperforms the Difference Between the Means (DBM) method, is consistent in explaining differences with few features and matches real patterns in data. We verify these claims by reproducing their experiments and testing their method on new data. We also investigate the use of more complex transformations to explain differences between clusters.