Miracle-dz/UniFAR-FTUs huggingface dataset:
Validation of the French Version of Conners’ Parent Rating Scale Revised, Short Version: Factorial Structure and Reliability

Objective: Attention-deficit hyperactivity disorder is one of the most frequent neurodevelopmental disorders. Its diagnosis requires reference questionnaires such as the Conners’ Parent Rating Scale (CPRS). Presently, in French-speaking countries, a few translations of the revised short CPRS have been put to use without previous formal validation. We sought here for the validation of a French version (Lausanne, Switzerland) of the revised short CPRS regarding construct validity, internal consistency, and item reliability in a sample of French schoolchildren. Method: The study involved 795 children and adolescents aged 9 to 19 years from a single school. The factorial structure and item reliability were assessed with a confirmatory factor analysis for ordered categorical variables. The dimension internal consistency was assessed with Guttman’s lambda 6 coefficient. Results: The results confirmed the original and strong 3-dimensional factorial structure (Oppositional, Cognitive Problems/Inattention, and Hyperactivity), showed satisfactory item reliability, and indicated a good dimension internal consistency (Guttman’s lambda 6 coefficient: 0.87, 0.90, and 0.82, respectively, to the 3 dimensions). Conclusions: Thus, the Lausanne French version of the revised short CPRS may be considered validated regarding construct validity and item and dimension reliability; it can be now more confidently used in clinical practice.
Racial Discrimination, Cultural Resilience, and Stress

Objective: Racial discrimination is a social determinant of health for First Nations people. Cultural resilience has been regarded as a potentially positive resource for social outcomes. Using a compensatory model of resilience, this study sought to determine if cultural resilience (compensatory factor) neutralized or offset the detrimental effect of racial discrimination (social risk factor) on stress (outcome). Methods: Data were collected from October 2012 to February 2013 (N = 340) from adult members of the Kettle and Stony Point First Nation community in Ontario, Canada. The outcome was perceived stress; risk factor, racial discrimination; and compensatory factor, cultural resilience. Control variables included individual (education, sociability) and family (marital status, socioeconomic status) resilience resources and demographics (age and gender). The model was tested using sequential regression. Results: The risk factor, racial discrimination, increased stress across steps of the sequential model, while cultural resilience had an opposite modest effect on stress levels. In the final model with all variables, age and gender were significant, with the former having a negative effect on stress and women reporting higher levels of stress than males. Education, marital status, and socioeconomic status (household income) were not significant in the model. The model had R2 = 0.21 and adjusted R2 = 0.18 and semipartial correlation (squared) of 0.04 and 0.01 for racial discrimination and cultural resilience, respectively. Conclusions: In this study, cultural resilience compensated for the detrimental effect of racial discrimination on stress in a modest manner. These findings may support the development of programs and services fostering First Nations culture, pending further study.
Ice Flow of the Antarctic Ice Sheet

A high-resolution map of ice motion in Antarctica shows the details of ice movement in a warming climate. We present a reference, comprehensive, high-resolution, digital mosaic of ice motion in Antarctica assembled from multiple satellite interferometric synthetic-aperture radar data acquired during the International Polar Year 2007 to 2009. The data reveal widespread, patterned, enhanced flow with tributary glaciers reaching hundreds to thousands of kilometers inland over the entire continent. This view of ice sheet motion emphasizes the importance of basal-slip–dominated tributary flow over deformation-dominated ice sheet flow, redefines our understanding of ice sheet dynamics, and has far-reaching implications for the reconstruction and prediction of ice sheet evolution.
Automatic synthesis and verification of compliance mappings

When the uncertainty is large compared to clearances between objects, some form of compliance is required for a robot to manipulate these objects. Such situations include, but are not restricted to, assembly operations. Compliance can be thought of as a task-dependent mapping from sensed forces to corrective motions which bring the robot closer to its goal. A methodology for the automated synthesis of this mapping is described. The possible erroneous configurations of the robot together with their resulting contact forces are computed, and a corrective motion is identified for each configuration. The validity of the mapping is checked to ensure that the sensed forces will provide unambiguous information during the actual execution of the planned compliant motion. <<ETX>>
Dopamine 2 Receptor Genes Are Associated with Raised Blood Glucose in Schizophrenia

Objective: Type 2 diabetes is commonly found in schizophrenia and is an important contributor to mortality and morbidity in this condition. Dopamine has been implicated in the aetiology of both diabetes and schizophrenia. It is possible that both disorders share a common genetic susceptibility. Methods: In a cross-sectional study, we examined 2 dopamine D2 receptor (DRD2) single-nucleotide polymorphisms (SNPs) previously associated with schizophrenia (C939 T, rs6275 and C957 T, rs6277) along with fasting blood glucose and body mass index (BMI) in 207 antipsychotic-treated patients with schizophrenia. All participants met DSM-IV criteria for schizophrenia, and those with other psychiatric disorders were excluded. Analysis of covariance was used to compare fasting glucose results by DRD2 genotypes, after controlling for known confounds. For significant associations, follow-up Bonferroni post hoc tests examined differences in fasting glucose levels between genotypes. Specific comparisons were also made using analysis of variance and chi-square (Fisher’s exact test). Results: The 2 DRD2 risk genotypes were associated with significant increases in blood glucose, after controlling for BMI, age, sex, dosage and type of antipsychotic medication, number of hospitalisations, and negative symptoms (rs6275, F(2, 182) = 5.901, P = 0.003; rs6277 SNP, F(2, 178) = 3.483, P = 0.033). Conclusions: These findings support the involvement of DRD2 not only in schizophrenia but also in elevated levels of blood glucose commonly found in antipsychotic-treated patients with schizophrenia. Our data support the notion that diabetes may not merely be a comorbid condition but could be fundamentally associated with the pathogenesis of schizophrenia itself.
Disentangling the Drivers of β Diversity Along Latitudinal and Elevational Gradients

Increases in species turnover of woody plants at low latitudes and elevations are explained by the size of species pools alone. Understanding spatial variation in biodiversity along environmental gradients is a central theme in ecology. Differences in species compositional turnover among sites (β diversity) occurring along gradients are often used to infer variation in the processes structuring communities. Here, we show that sampling alone predicts changes in β diversity caused simply by changes in the sizes of species pools. For example, forest inventories sampled along latitudinal and elevational gradients show the well-documented pattern that β diversity is higher in the tropics and at low elevations. However, after correcting for variation in pooled species richness (γ diversity), these differences in β diversity disappear. Therefore, there is no need to invoke differences in the mechanisms of community assembly in temperate versus tropical systems to explain these global-scale patterns of β diversity.
Presence and Predictive Value of Obsessive-Compulsive Symptoms in Anxiety and Depressive Disorders

Objective: Obsessive-compulsive symptoms (OCS) co-occur frequently with anxiety and depressive disorders, but the nature of their relationship and their impact on severity of anxiety and depressive disorders is poorly understood. In a large sample of patients with anxiety and depressive disorders, we assessed the frequency of OCS, defined as a Young Adult Self-Report Scale–obsessive-compulsive symptoms score >7. The associations between OCS and severity of anxiety and/or depressive disorders were examined, and it was investigated whether OCS predict onset, relapse, and persistence of anxiety and depressive disorders. Methods: Data were obtained from the third (at 2-year follow-up) and fourth wave (at 4-year follow-up) of data collection in the Netherlands Study of Anxiety and Depression cohort, including 469 healthy controls, 909 participants with a remitted disorder, and 747 participants with a current anxiety and/or depressive disorder. Results: OCS were present in 23.6% of the total sample, most notably in those with current combined anxiety and depressive disorders. In patients with a current disorder, OCS were associated with severity of this disorder. Moreover, OCS predicted (1) first onset of anxiety and/or depressive disorders in healthy controls (odds ratio [OR], 5.79; 95% confidence interval [CI], 1.15 to 29.14), (2) relapse in those with remitted anxiety and/or depressive disorders (OR, 2.31; 95% CI, 1.55 to 3.46), and (3) persistence in patients with the combination of current anxiety and depressive disorders (OR, 4.42; 95% CI, 2.54 to 7.70) within the 2-year follow-up period Conclusions: OCS are closely related to both the presence and severity of anxiety and depressive disorders and affect their course trajectories. Hence, OCS might be regarded as a course specifier signaling unfavorable outcomes. This specifier may be useful in clinical care to adapt and intensify treatment in individual patients.
A smooth robust nonlinear controller for robot manipulators with joint stick-slip friction

The design of a smooth robust nonlinear controller for the regulation of an n-degree-of-freedom rigid robot with internal joint stick-slip friction is presented. It is shown that not only positioning accuracy, but also smoothness of motion is improved through nonlinear feedback. The Lyapunov direct method is employed to prove the global stability of the closed-loop system. The desired accuracy can be achieved by adjusting the parameters of the controller. The nonlinear compensator is robust with respect to the character of the slipping torque. Only the maximum static friction torque of the internal joint is required for controller design. The numerical implementation of this controller on a two-link robot is presented. <<ETX>>
A principle of distributed decision making of Cellular Robotic System (CEBOT)

The Cellular Robotic System (CEBOT) is studied with the aim of realizing a self-organizing robotic system. A principle of the distributed decision making method for a multi-agents robotic system is reported. Some simple control laws which each unit should obey are proposed. The conditions of parameters of the control laws to keep the total system stable are also discussed. To demonstrate the efficiency of the proposed method, a simple task (carry the object) is carried out by some mobile cells which obey the methods from simulation experiments. The optimal number of cells to execute the task is evaluated and discussed. <<ETX>>
Asynchronous Diversification in a Specialized Plant-Pollinator Mutualism

Insect sensory biases played a major role in driving reproductive adaptations in flowering plants. Most flowering plants establish mutualistic associations with insect pollinators to facilitate sexual reproduction. However, the evolutionary processes that gave rise to these associations remain poorly understood. We reconstructed the times of divergence, diversification patterns, and interaction networks of a diverse group of specialized orchids and their bee pollinators. In contrast to a scenario of coevolution by race formation, we show that fragrance-producing orchids originated at least three times independently after their fragrance-collecting bee mutualists. Whereas orchid diversification has apparently tracked the diversification of orchids’ bee pollinators, bees appear to have depended on the diverse chemical environment of neotropical forests. We corroborated this apparent asymmetrical dependency by simulating co-extinction cascades in real interaction networks that lacked reciprocal specialization. These results suggest that the diversification of insect-pollinated angiosperms may have been facilitated by the exploitation of preexisting sensory biases of insect pollinators.
Addressing Mental Health Needs of Refugees

Throughout history, refugees have alternatively been seen as entitled victims of adversity or as threats or abusers of host countries scarce resources. Within the present globalized context, ambivalent public perceptions of refugees are shattering the protective nature of the post migratory environment in refugee receiving countries. This raises new challenges for refugees’ mental health and calls for systemic responses to address both pre-migratory trauma and losses and post migratory adversities. Recent evidence on the effectiveness of mental health treatment for refugees confirms the utility of trauma-focused psychotherapy and the limits of psychopharmacology for stress related disorders in this group. Training of mental health professionals may improve the quality of care for refugees by deconstructing prevalent prejudices about them and promoting empathic understanding. Mental health professionals may also advocate by providing information about social determinants refugee mental health to policy makers and promoting psychosocial interventions and protective social policies.
Static and dynamic characteristics of McKibben pneumatic artificial muscles

This paper reports mechanical testing and modeling results for the McKibben artificial muscle pneumatic actuator. This device first developed in the 1950's, contains an expanding tube surrounded by braided cords. The authors report static and dynamic length-tension testing results and derive a linearized model of these properties for three different models. The results are briefly compared with human muscle properties to evaluate the suitability of McKibben actuators for human muscle emulation in biologically based robot arms. <<ETX>>
Performance trade-offs for hand controller design

Realistic specifications are developed for hand controller mechanical and control design, based on limitations of human operator motion and perception capabilities observed in initial experimental studies. A representative dynamic model is used to develop expressions for the limits on closed loop hand controller impedance. Specific trade-offs are derived between mechanical design options and control design options for achieving realistic performance specifications. Implications of these trade-offs in designing "ideal-equivalent" hand controllers are discussed, and applied to a high-performance laboratory hand controller prototype. <<ETX>>
Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

Evidence for a possible route for DNA demethylation in animals is suggested. 5-methylcytosine (5mC) in DNA plays an important role in gene expression, genomic imprinting, and suppression of transposable elements. 5mC can be converted to 5-hydroxymethylcytosine (5hmC) by the Tet (ten eleven translocation) proteins. Here, we show that, in addition to 5hmC, the Tet proteins can generate 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) from 5mC in an enzymatic activity–dependent manner. Furthermore, we reveal the presence of 5fC and 5caC in genomic DNA of mouse embryonic stem cells and mouse organs. The genomic content of 5hmC, 5fC, and 5caC can be increased or reduced through overexpression or depletion of Tet proteins. Thus, we identify two previously unknown cytosine derivatives in genomic DNA as the products of Tet proteins. Our study raises the possibility that DNA demethylation may occur through Tet-catalyzed oxidation followed by decarboxylation.
Locomotor Primitives in Newborn Babies and Their Development

Mammalian locomotion patterns share common roots. How rudimentary movements evolve into sophisticated ones during development remains unclear. It is often assumed that the primitive patterns of neural control are suppressed during development, replaced by entirely new patterns. Here we identified the basic patterns of lumbosacral motoneuron activity from multimuscle recordings in stepping neonates, toddlers, preschoolers, and adults. Surprisingly, we found that the two basic patterns of stepping neonates are retained through development, augmented by two new patterns first revealed in toddlers. Markedly similar patterns were observed also in the rat, cat, macaque, and guineafowl, consistent with the hypothesis that, despite substantial phylogenetic distances and morphological differences, locomotion in several animal species is built starting from common primitives, perhaps related to a common ancestral neural network.
Two Space-time Interaction Tests for Epidemicity *

1. INTRODUCToN Knox (1964), in discussing the pattern of incidence of childhood leukaemia in Northumberland and Durham, used a test for interaction in time and space which he had set out in an earlier paper (Knox, 1963). He was able only to conjecture the distribution of his test criterion. We have been able to show that his conjecture is substantially correct and that the distribution is Poisson in large samples. It is the purpose of this note first to give the exact mean and variance of Knox's criterion. If the distribution is assumed to be Poisson then the mean and variance should be approximately equal and in any practical problem the calculation of them both will serve as a guide to the adequacy of the assumption. Secondly, we give a space-time test of our own and apply it to Knox's data which he very kindly put at our disposal.
Canadian Nursing Students and the Care of Older Patients

The aim of this research was to contribute to an understanding about the professionalization of gerontological nursing. The specific objective was to explore attitudes about older people among undergraduate nursing students. Three focus groups were carried out with 3rd-year nursing students in a generalist program in a small Canadian city and discussions focused on experiences and attitudes surrounding the care of older patients. A qualitative descriptive approach was used to analyze the verbatim transcripts. Results indicated that students had positive reactions to caring for older patients, at least when dementia is not present, but they received a strong message from their mentors that this type of nursing is neither prestigious nor valued. Discussions surrounding the care of older adults highlighted students’ perceptions of conflicts between the art and science of nursing, and their concerns regarding the divisions of tasks between nursing students, registered nurses, and licensed practical nurses.
Coronary Brachytherapy and Restenosis

The antiproliferative effects of radiotherapy have been used clinically for over 100 years to treat several benign disorders. More recently, several experimental studies have convincingly demonstrated that the use of intracoronary radiotherapy results in marked modulation of the restenotic process. Currently, several systems are undergoing clinical evaluation. Radiotherapy with gamma radiation has been conclusively shown to have a major impact on the long-term prevention of restenosis following percutaneous intervention. Several systems using beta radiation, delivering a more localised form of radiotherapy, have also been used with very promising results in the short to mid-term. Whilst inhibition of restenosis at the target site is a consistent finding, both forms of radiotherapy can be complicated by recurrences at the edges and by late thrombotic occlusion. Both these limitations should be minimised by improved lesion coverage by the radiation source and by prolonged (6 months) anti-platelet therapy. Although there is clear convergence of evidence to suggest that many radiotherapy systems are highly effective in the short and mid-term, a prolonged follow-up period over several years will be necessary to make a definitive conclusion about their wide-scale clinical application.
Active Starvation Responses Mediate Antibiotic Tolerance in Biofilms and Nutrient-Limited Bacteria

During growth arrest, bacteria tolerate the presence of antibiotics, thanks to mechanisms that protect against oxidant stress. Bacteria become highly tolerant to antibiotics when nutrients are limited. The inactivity of antibiotic targets caused by starvation-induced growth arrest is thought to be a key mechanism producing tolerance. Here we show that the antibiotic tolerance of nutrient-limited and biofilm Pseudomonas aeruginosa is mediated by active responses to starvation, rather than by the passive effects of growth arrest. The protective mechanism is controlled by the starvation-signaling stringent response (SR), and our experiments link SR-mediated tolerance to reduced levels of oxidant stress in bacterial cells. Furthermore, inactivating this protective mechanism sensitized biofilms by several orders of magnitude to four different classes of antibiotics and markedly enhanced the efficacy of antibiotic treatment in experimental infections.
Self-assembling machine

The design of a machine which is composed of homogeneous mechanical units is described. We show the design of both hardware and control software of the unit. Each unit can connect with other units and change the connection by itself. In spite of its simple mechanism, a set of these units realizes various mechanical functions. We developed the control software of the unit which realizes "self-assembly," one of the basic functions of this machine. A set of these units can form a given shape of the whole system by themselves. The units exchange information about local geometric relation by communication, and cooperate to form the whole shape through a diffusion-like process. There is no upper level controller to supervise these units, and the software of each unit is completely the same. Three actual units have been built to test the basic movements, and the function of self-assembly has been verified by computer simulation. <<ETX>>
Interactive graphical model building using telepresence and virtual reality

Presents a prototype system developed at Sandia National Laboratories to create and verify computer-generated graphical models of remote physical environments. The goal of the system is to create an interface between an operator and a computer vision system so that graphical models can be created interactively. Virtual reality and telepresence are used to allow interaction between the operator, computer, and remote environment. A stereo view of the remote environment is produced by two CCD cameras. The cameras are mounted on a three degree-of-freedom platform which is slaved to a mechanically-tracked, stereoscopic viewing device. This gives the operator a sense of immersion in the physical environment. The stereo video is enhanced by overlaying the graphical model onto it. Overlay of the graphical model onto the stereo video allows visual verification of graphical models. Creation of a graphical model is accomplished by allowing the operator to assist the computer in modeling. The operator controls a 3-D cursor to mark objects to be modeled. The computer then automatically extracts positional and geometric information about the object and creates the graphical model. <<ETX>>