Miracle-dz/UniFAR-FTUs huggingface dataset:
Auditory grouping occurs prior to intersensory pairing

The authors examined how principles of auditory grouping relate to intersensory pairing. Two sounds that normally enhance sensitivity on a visual temporal order judgement task (i.e. temporal ventriloquism) were embedded in a sequence of X anker sounds which either had the same or di V erent frequency (Exp. 1), rhythm (Exp. 2), or location (Exp. 3). In all experiments, we found that temporal ventriloquism only occurred when the two capture sounds di V ered from the X ankers, demonstrating that grouping of the sounds in the auditory stream took priority over intersensory pairing. By combining principles of auditory grouping with intersensory pairing, we demonstrate that capture sounds were, counter-intuitively, more e V ective when their locations di V ered from that of the lights rather than when they came from the same position as the lights.
Nutrition, Metabolism Tumor necrosis factor alpha reduces intestinal vitamin C uptake: a role for NF- (cid:2) B-mediated signaling

necrosis factor- (cid:3) reduces intestinal vitamin C uptake: a role for NF- (cid:2) B-mediated signaling. Am J Physiol Gastrointest Liver Physiol 315: G241–G248, vitamin C transporter-1 (SVCT-1) is the major transporter mediating intestinal vitamin C uptake. Intestinal inﬂammation and prolonged infection are associated with increased serum and intestinal mucosa levels of tumor necrosis factor- (cid:3) (TNF- (cid:3) ), which also exerts profound effects on the intestinal absorption process. Elevated levels of TNF- (cid:3) have been linked to the pathogenesis of inﬂammatory bowel disease (IBD) and malabsorption of nutrients, and patients with this condition have low levels of vitamin C. To date, little is known about the effect of TNF- (cid:3) on intestinal absorption of vitamin C. We studied the impact of TNF- (cid:3) on ascorbic acid (AA) transport using a variety of intestinal prepara- tions. The expression level of human SVCT-1 mRNA is signiﬁcantly lower in patients with IBD. TNF- (cid:3) treated Caco-2 cells and mice showed a signiﬁcant inhibition of intestinal 14 C-AA uptake. This inhibition was associated with signiﬁcant decreases in SVCT-1 pro- tein, mRNA, and heterogeneous nuclear RNA levels in TNF- (cid:3) treated Caco-2 cells, mouse jejunum, and enteroids. Also, TNF- (cid:3) caused a signiﬁcant inhibition in the SLC23A1 promoter activity. Furthermore, treatment of Caco-2 cells with celastrol (NF- (cid:2) B inhibitor) blocked the inhibitory effect caused by TNF- (cid:3) on AA uptake, SVCT-1 protein, and mRNA expression, as well as the activity of SLC23A1 promoter. (cid:3) to a signiﬁcant the of hepatocyte nuclear factor-1- (cid:3) which the basal activity of SLC23A1 SLC23A1 transporter-1) was transferred by electroblotting onto immobilon PVDF membrane. Subsequently, the blot was probed with human SVCT-1 (1:200), HNF1 (cid:3) (1:200), NF- (cid:2) B (1:400), I (cid:2) B (cid:3) (1:2,000), laminin (1:200), and (cid:6) -actin (1:5,000) antibodies and mouse SVCT-1 (1:500) and (cid:6) -actin (1:3,000) antibodies. After PBS-Tween 20 washes, the blot was incubated with secondary antibodies (1:30,000, anti-rabbit IRDye 800 and/or anti-mouse IRDye 680; LI-COR Biosciences) for 45 min. The immunoreactive ﬂuorescent bands were captured using an Odyssey infrared imaging system (LI-COR Biosciences), and speciﬁc intensity was determined using LI-COR software.
Branched-Chain Amino Acids and Postoperative Quality of Life in Hepatectomied Patients Austin

Patients with chronic liver disease often reach a state of protein-energy malnutrition, which may influence patient outcomes following surgery and subsequent quality-of-life (QOL). Recent assessments of QOL integrate a biochemical health model with a social science model that is based on the patient’s subjective perception of functioning and wellbeing across a range of physical, mental and social aspects of life. Since most liver neoplasms occur in patients with chronic liver disease, hepatic resection could potentially reduce QOL in these patients by further compromising liver function. Advances in surgical technology and perioperative management have led to hepatic surgical procedures, including liver resection and radiofrequency ablation, being the mainstay of curative treatment for not only hepatocellular carcinoma (HCC), but also metastatic liver tumors. However, hepatic surgery is still associated with postoperative morbidities due to the inevitable deterioration of liver function following a reduction in functioning liver mass. Based on the clinical assessment, dieticians should therefore educate patients and carers about sodium and fluid restriction, and appropriate food choices. In this context, branched-chain amino acid (BCAA) nutritional supplementation improves postoperative QOL over the long term after hepatic resection by restoring and maintaining nutritional status and whole-body kinetics. BCAA may also inhibit carcinogenesis in heavier patients with cirrhosis and play a key role in liver regeneration. Individualized intervention is thus recommended based on patient’s nutritional status.
Bortezomib Inhibits Nuclear Factor- K B ^ Dependent Survival and Has Potent In vivo Activity in Mesothelioma Preclinical

Purpose: Purpose of this study has been the assessment of nuclear factor- n B (NF- n B) as a survival factor inhuman mesothelial cells (HMC), transformed HMC and malignant mesothelioma (MMe) cells.We aimed at verifying whether the proteasome inhibitor Bortezomib could abrogate NF- n B activity in MMe cells, leading to tumor cell death and may be established as a novel treatment for this aggressive neoplasm. Experimental Design: In HMC and MMe cells, NF- n B nuclear translocation and DNA binding were studied by electrophoretic mobility shift assay, following treatment with tumor necrosis factor- a (TNF- a ). The IKK inhibitor Bay11-7082 was also tested to evaluate its effects on HMC, transformed HMC, and MMe cell viability upon exposure to asbestos fibers. Following Bortezomib treatment, cytotoxicity of MMe cells was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, whereas apoptosis and cell-cycle blockade were investigated by high-content analysis. Bortezomib was also given to mice bearing i.p. xenografts of MMe cells, and its effects on tumor growth were evaluated. Results: Here, we show that NF- n B activity is a constitutive survival factor in transformed HMC, MMe cells, and acts as a survival factor in HMC exposed to asbestos fibers. Bortezomib inhibits NF- n B activity in MMe cells and induces cell cycle blockade and apoptosis in vitro as well as tumor growth inhibition in vivo . Conclusions: Inhibition of NF- n B constitutive activation in MMe cells by Bortezomib resulted in in vitro cytotoxicity along with apoptosis and in vivo tumor regression. Our results support the use of Bortezomib in the treatment of MMe andhas led to aphase IIclinical trial currentlyenrolling in Europe. analyses, we used log-transformed values of tumor weight; to address zero values, 0.01 mg/kg was added to each tumor- weight value before the transformation. We used the Kruskal-Wallis test of equality of populations to assess for differences among the ranked values of diaphragm involvement. Because there were no statistically significant differences among the two trials in measures (by treatment class) of ascite or diaphragm involvement, we assessed treatment differences of these measures within and across trials; because of a significant difference in tumor weight between trials, we did within-trial analyses only for this measure.
Modulation of Substrate Efﬂux in Bacterial Small Multidrug Resistance Proteins by Mutations at the Dimer Interface (cid:1)

Bacteria evade the effects of cytotoxic compounds through the efﬂux activity of membrane-bound transport- ers such as the small multidrug resistance (SMR) proteins. Consisting typically of ca. 110 residues with four transmembrane (TM) (cid:1) -helices, crystallographic studies have shown that TM helix 1 (TM1) through TM helix 3 (TM3) of each monomer create a substrate binding “pocket” within the membrane bilayer, while a TM4-TM4 interaction accounts for the primary dimer formation. Previous work from our lab has characterized a highly conserved small-residue heptad motif in the Halobacterium salinarum transporter Hsmr as 90 GLXLIXXGV 98 that lies along the TM4-TM4 dimer interface of SMR proteins as required for function. Focusing on conserved positions 91, 93, 94, and 98, we substituted the naturally occurring Hsmr residue for Ala, Phe, Ile, Leu, Met, and Val at each position in the Hsmr TM4-TM4 interface. Large-residue replacements were studied for their ability to dimerize on SDS-polyacrylamide gels, to bind the cytotoxic compound ethidium bromide, and to confer resistance by efﬂux. Although the relative activity of mutants did not correlate with dimer Modeling of Hsmr TM4 dimers. Potential dimerization sites for the Hsmr TM4 and mutants were identiﬁed using the CNS searching of helix interactions (CHI) software suite of the crystallography and nuclear magnetic resonance (NMR) system (CNS) as previously described (3, 20). The antiparallel Hsmr WT structure of TM4 (residues 85 to 105, inclusive) was chosen based on its similarity to the EmrE TM4 crystal structure (5, 20), and mutant structures were selected based on the proximity to the WT structure by measuring the intermonomer Gly90-to-Gly97 C (cid:2) distances of each mutant. Comparisons of WT and mutant deviation (RMSD) values and imaging were performed using PyMOL (DeLano Scientiﬁc).
Side Chain Cleavage Enzyme (CYPI IA I) Promoter through ras-and Ets-2L-Signaling Pathways

Expression of the ovine P-450 side-chain cleavage enzyme gene (CYPl lA1) is stimulated by epidermal growth factor (EGF) through a pathway that involves c-Jun in JEG-3 placental cells. Growth factor signaling involves /as-dependent and ras-inde-pendent signaling pathways, which in turn regulate gene transcription through related but distinct mi-togen-activated protein kinase pathways (MAPKs) including the extracellular signal-regulated kinases (ERKs) and the stress-activated protein kinases (SAPKs). We investigated the intracellular signaling pathways governing EGF induction of the CYPllAl promoter. EGF stimulation of the CYPllAl promoter (4-fold) was reduced 66% by a dominant negative mutant of ras (Nl7), and 3946% by antisense ras. EGF induced both ERK and SAPK activity in JEG-3 cells. EGF-induced CYPllAl promoter activity was reduced 69% by the MEKI inhibitor PDCl96969 and 69% by a dominant negative mutant of the ERK-specific regulator MEKI . In contrast, dominant negative mutants of the SAPK-specific activator, SEKl, induced a further increase in EGF-induced CYPllAl promoter activity. Constitutively active mutants of ras (VI 2 or L61) increased CYPl 1Al promoter activity 6- to 6-fold. Deletion of the EGF response element (EGF-RE) between -92 and -77 bp reduced ras induction by 69%; however, a residual g-fold induction remained through the proximal -77 bp. Mutation of the EGF-RE AP-l-like sequence in the context of the native promoter reduced CYPllAl promoter activation by ras 66%. The EGF-RE sequence was suffi-0686-8609/96/$3.00/O cient for 6-fold activation by ras in the context of an heterologous thymidine kinase promoter. Candidate transcription factor targets (c-Jun, c-Ets-2) for the ras-signaling cascade were examined for their effects on CYPllAl promoter activity. Overexpression of c-Jun induced the CYPllAl promoter through the EGF-RE; however, c-Ets-2 activation of the CYPllAl promoter (12-fold) required the proximal fas-respon-sive promoter sequences that are distinct from the EGF/MEK/c-Jun-responsive element. Induction of the CYPl lA1 promoter by EGF involves a ras/MEKl/ AP-1 -dependent pathway that is distinct from induction by r&c-Ets-2. (Molecular Endocrinology
B Cell–speciﬁc Transgenic Expression of Bcl2 Rescues Early B Lymphopoiesis but Not B Cell Responses in BOB.1/OBF.1-deﬁcient Mice

Mice deficient for the transcriptional coactivator BOB.1/OBF.1 show several defects in B cell differentiation. Numbers of immature transitional B cells in the bone marrow are reduced and fewer B cells reach the periphery. Furthermore, germinal center B cells are absent and marginal zone (MZ) B lymphocytes are markedly reduced. Increased levels of B cell apoptosis in these mice prompted us to analyze expression and function of antiapoptotic proteins. Bcl2 expression is strongly reduced in BOB.1/OBF.1-deficient pre–B cells. When BOB.1/OBF.1-deficient mice were crossed with Bcl2-transgenic mice, B cell development in the bone marrow and numbers of B cells in peripheral lymphoid organs were normalized. However, neither germinal center B cells nor MZ B cells were rescued. Additionally, Bcl2 did not rescue the defects in signaling and affinity maturation found in BOB.1/OBF.1-deficient mice. Interestingly, Bcl2-transgenic mice by themselves show an MZ B cell defect. Virtually no functional MZ B cells were detected in these mice. In contrast, mice deficient for Bcl2 show a relative increase in MZ B cell numbers, indicating a previously undetected function of Bcl2 for this B cell compartment.
Deep Learning Applied to PMU Data in Power Systems

The analysis of power system disturbances is fundamental to ensure the reliability and security of the supply. In fact, capturing the sequence of system states over a disturbance is an increased value to understand its origin. Phasor Measurement Units (PMUs) have the ability to record these fast transients with high precision, by providing synchronized measurements at high sampling rates. Indeed, these events can occur in a few seconds, which hampers their detection by the traditional SCADA (Supervisory Control and Data Acquisition) systems and emphasizes the uniqueness of PMUs. With the advent of Wide Area Measurement Systems (WAMS) and the consequent deployment of such monitoring devices, control centers are being flooded with massive volumes of data. Therefore, transforming data into knowledge, preferably automatically, is an actual challenge for system operators. Under abnormal operating conditions, the data collected from several PMUs scattered across the grid can shape a sort of a "movie" of the disturbance. The importance of WAMS is therefore sustained on their ability to capture the sequence of events resulting from a disturbance, helping the further analysis procedures. Driven by the amounts of data involved, this dissertation proposes the application of Deep Learning frameworks to perform automatic disturbance classification. In order to do so, a set of measurements from several PMUs installed in the Low Voltage grid of an interconnected system is used, from which representative patterns are extracted so as to endow a classifier of knowledge related to system disturbances. In particular, the strategies herein adopted consist of the application of Multilayer Perceptrons, Deep Belief Networks and Convolutional Neural Networks, the latter having outperformed the others in terms of classification accuracy. Additionally, these architectures were implemented in both the CPU and the GPU to ascertain the resulting gains in speed.
coatings Efﬁciency of Application of (Mo, Al)N-Based Coatings with Inclusion of Ti, Zr or Cr during the Turning of Steel of Nickel-Based Alloy

: The article compares the properties of multilayer composite wear-resistant coatings of Zr–ZrN–(Zr, Mo, Al)N, Ti–TiN–(Ti, Mo, Al)N, and Cr–CrN–(Cr, Mo, Al)N. The investigation was focused on hardness, resistance to fracture during scratch tests, elemental composition, and structure of the coatings. Experiments were carried out to study the wear resistance of coated carbide tools during the turning of 1045 steel and of NiCr20TiAl heat-resistant nickel alloy. With the elemental compositions identical in the content of molybdenum (Mo) and aluminium (Al), identical thicknesses and nanolayer periods of λ , the coatings being studied demonstrated a noticeable difference in wear resistance. Both during the turning of steel and nickel-based alloy, the highest wear resistance was detected for tools with the Zr–ZrN–(Zr, Mo, Al)N coating (the tool life was 3–5 times higher than for uncoated tools). The good wear resistance of the Zr–ZrN–(Zr, Mo, Al)N coating may be related to the optimal combination of hardness and plasticity and the active formation of molybdenum oxide (MoO 3 ) on the coating surface during the cutting, with good tribological and protective properties.
Institutional Knowledge at Singapore Management University Probabilistic Latent Document Network Embedding

—A document network refers to a data type that can be represented as a graph of vertices, where each vertex is associated with a text document. Examples of such a data type include hyperlinked Web pages, academic publications with citations, and user proﬁles in social networks. Such data have very high-dimensional representations, in terms of text as well as network connectivity. In this paper, we study the problem of embedding, or ﬁnding a low-dimensional representation of a document network that “preserves” the data as much as possible. These embedded representations are useful for various applications driven by dimensionality reduction, such as visualization or feature selection. While previous works in embedding have mostly focused on either the textual aspect or the network aspect, we advocate a holistic approach by ﬁnding a uniﬁed low-rank representation for both aspects. Moreover, to lend semantic inter- pretability to the low-rank representation, we further propose to integrate topic modeling and embedding within a joint model. The gist is to join the various representations of a document (words, links, topics, and coordinates) within a generative model, and to estimate the hidden representations through MAP estimation. We validate our model on real-life document networks, showing that it outperforms comparable baselines comprehensively on objective evaluation metrics.
Performance Evaluation and Field Characterization of the Sifang Mini Rice Combine Harvester

Abstract. Performance of a Sifang mini rice combine, originally developed in China, was evaluated under local farmer field conditions in Benin. Results from field evaluation show that the combine worked satisfactorily on less dense rice fields with minimal weeds at grain moisture contents between 19.1% and 20.1% w.b. on soils with moisture content from 23% to 33% d.b. while causing no significant changes to soil physical properties. With harvesting speed ranging from 0.8 to 4. 5Â km/h, the harvester had a field capacity of 0.10 to 0.39 ha/h and consumed fuel of up to 11 L/ha while having track slip of 6% to 9%. Harvesting using 2- and 1-L gear offered the best efficiency for IR841 and Nerica L20 rice varieties, respectively. As harvesting speed increased, harvesting efficiency decreased and crop throughput increased irrespective of rice variety. The combine produced low mechanical grain damage with total grain loss ranging from 1.43% to 4.43% and 1.85% to 5.6% for the IR841 and Nerica L20 rice varieties, respectively. At an investment cost of US$5000 and hiring at US$10 per h, owning the mini combine harvester becomes profitable after 342 h of machine use; equivalent to approximately 133Â ha of paddy field harvested at a harvesting capacity of 0.39 ha/h. Further testing of the combine under a wide range of crop and soil conditions across different agro-ecological zones and economic comparison with manual harvesting is recommended. This would offer smallholder farmers diverse options of rice harvesting mechanization to facilitate future adoption of improved technologies.
Synthesis of Ag/ZIF-67 as a Heterogeneous Catalyst for Methyl Orange Degradation in Presence of H 2 O 2

— A metal-organic framework Ag/ZIF-67 was successfully synthesized and characterized by several methods including X-ray powder diffraction (PXRD), Fourier transform infrared (FT-IR), Scanning electron microscopy (SEM), and Thermogravimetric analysis (TGA). The results showed that Ag/ZIF-67 had a polyhedron structure was similar with ZIF-67 and 5.1% of Ag nanoparticles was loaded into its structure. The catalytic activity of Ag/ZIF-67 was then investigated into methyl orange (MO) minerization process in presence of H 2 O 2 . High efficiency was obtained with over 99% when using H 2 O 2 concentration 0,08 mol.L -1 , methyl orange concentration 10 mg.L -1 , Ag/ZIF-67 concentration 200 mg.L -1 at 30 o C, pH 7 in 180 min. The solid and could be recycled and reused without a significant degradation in catalytic activity with the efficiency is over 90% after 3 times.
Carcass and Meat Quality in Goat Carcass and Meat Quality in Goat

Goat is a worldwide spread species with different specialities and aptitudes, among the meat production. Its consumption varies widely depending on the region of the world considered. However, a common factor is the presence of few studies in comparison with ovine, especially those that characterize the quality of its products (related to carcass and meat). Generation, availability, and diffusion of characteristics of the species and its production, generated from scientific studies, could help breeders and society on their education and raising global awareness of its importance, conservation, and productive possibilities. Goat has its own specific characteristics related to quality with a presumed good acceptability of its products by consumers. On the current chapter, the effects of the main factors that modify carcass and meat quality in goat are compiled. Both, intrinsic factors (breed or breed type, age, weight at slaughter or gender) and some extrinsic fac - tors (as production system, type of suckling, and aging) are discussed.
BIOLOGICAL EVALUATION OF LOW – FAT CAKE

Low- fat cake prepared by partial replacement of shortening with Maltodextrin or Simplesse were organoleptically evaluated and subjected to analysis for gross composition and caloric value. A nutrition experiment on rats was conducted to determine the effect of low – fat cake diet on growth parameters and serum lipid profile. The sensory evaluation results indicated that no significant difference (P≤ 0.05) was found among replacement treatments up to 50% replacement level and the full fat cake, and the panelists considered that, all treatments were acceptable up to 75% replacement level. The results of gross chemical composition and caloric value showed a significant decreased (P≤ 0.05) in fat content and caloric value by increasing fat replacement level. The final body weight, weight gain, feed efficiency ratio and the organ weight (% of body weight) of rats were not significantly (P≤ 0.05) affected by fat replacement. Triglycerides (T.G), total cholesterol and low density lipoprotein cholesterol (LDL-C) of serum were significantly (P≤ 0.05) decreased by replacement 50% or 75% of shortening using both fat replacers. The calculated Atherogenic Index was significantly decreased (P≤ 0.05) by fat replacement at ratio of 25%, 50% and 75% by using maltodextrin or at ratio of 50% and 75% by simplesse.