Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of Extracranial Veins Endovascular Procedures on the Quality of Life in Patients with Multiple Sclerosis – Follow Up After 1 Year

Background: Chronic cerebrospinal venous insufficiency is a new term which highlights the role of extracranial venous anomalies. Stenoses of the jugular and the azygous veins hinder venous drainage and may influence brain perfusion and cerebrospinal fluid flow. Materials and Methods: In patients with relapsing-remitting and progressive course of multiple sclerosis with a proven obstruction of neck veins percutaneous transluminal angioplasty was performed. We evaluated the clinical disability and quality of life in terms of fatigue, cognitive, psychosocial and bladder dysfunction one year after angioplasty. Results: In the relapsing-remitting group of patients an improvement of disability was observed, whereas in patients with the progressive course of the disease a stable clinical status was noticed. Both patient groups showed a significant improvement of fatigue. Cognitive and psychosocial impact on the quality of life showed better outcome in patients with advanced course of the disease than in less affected patients. Important amelioration of bladder dysfunction was achieved in both groups. Conclusion: Endovascular procedures of extracranial venous anomalies demonstrated an encouraging effect in patients with relapsing-remitting and progressive course of the disease. It seems that the removal of vein obstructions improves many non-motor symptoms which importantly contribute to the quality of life in MS patients. is discussed [8]. Due to venous occlusions, the amount of toxic radicals in the central nervous system (CNS) accumulates and enhances the process of inflammation. MS is a chronic inflammatory progressive immune-mediated demyelinating disease of CNS characterized by inflammation, demyelination, diffuse axonal damage and neuronal loss. The cause and pathogenesis of MS are still unknown. Most of the patients have a relapsing-remitting (RR) course of the disease. About 15% of patients start with a primary progressive form of the disease (PP). After 10-Research
RF-Heartbeat: Robust and Contactless Heartbeat Monitoring RF-Heartbeat: Robust and Contactless Heartbeat Monitoring Based on FMCW Radar Based on FMCW Radar

—Heartbeat is a significant vital sign. In the era of 5G and Internet of Things (IOT), wireless heartbeat monitoring becoming more and more feasible. As a contactless approach, it can relieve users from wearing sensors. The unique advantages of milimeter-wave (mmWave) frequency-modulated continous-wave (FMCW) radar over other wireless devices draw our attention. We propose RF-Heartbeat, a robust heartbeat monitoring system based on commodity mmWave FMCW radar device. RF-Heartbeat has novel signal process modules, including body movements (BMs) handling method, and optimal range bin selection method, for obtaining a relatively high-quality heartbeat signal. Then, a global optimization model based on a template matching algorithm is implemented for improving IBI estimation accuracy. In the heartbeat monitoring experiment for a total of 72 hours and 56 minutes involving 10 participants, under a time coverage of 91.2%, the median error of IBI was 12 ms. RF-Heartbeat achieves a higher performance than state-of-the-art heartbeat monitoring systems. It has strong robustness to different individuals in different postures and positions. Our work provides effective solutions to some limitations in practical applications of contactless heartbeat monitoring. It can be deployed on IOT system in clinical environment and smart home, and has the potential to enable ubiquitous and unobtrusive heartbeat monitoring.
Theory and practice of force measurement

The senior author, A. Bray, has been with the Institute of Metrology "G. Colonetti" in Turin, Italy, for many years, having established the first nucleus of the institute, which is today the Force Measurement Section. His colleagues G. Barbato and R. Levi are associated also with Politecnico di Torino. Reflective of the authors' experience, the major focus of the book is on high accuracy force measurement and calibration in standards laboratories. This relatively narrow focus limits the range of readership to which the book is addressed, but allows a high technical level in the treatment of those topics which are covered. Of the eight chapters, only the fifth, "Force-Measuring Devices," would be of prime interest to the more general force-measurement community. The entire book, however, is of uniformly high quality and fills an important gap in the measurement literature. While the authors' foreword indicates a translation from Italian, I could really detect no evidence of this in the text's usage. I found the material very well organized and presented and a pleasure to read. Illustrations are quite numerous and well executed, equations are clearly numbered, references are profuse and significant, and the index is extensive and useful. As mentioned earlier, however, the book does not attempt to cover, except by brief mention, all the common methods used to measure force in laboratory and industrial applications and the difficult practical problems attendant to such uses. Measurement of unsteady (dynamic) forces, for example, is not covered. Each chapter is briefly reviewed below:
Heavy metal concentrations in environmental samples and amphibian tissues in the Niger Delta, Nigeria: correlations with parasite species

: Soil samples and amphibian host specimens were collected monthly from Agbada, an oil flow station in the Niger Delta region of Nigeria, for heavy metal analysis and also for the recovery of the helminth endo-parasites of the amphibians. Collection of samples was done monthly for a period of twelve months and heavy metal analysis was done by wet digestion of environmental and biological samples using atomic absorption spectrophotometer. Parasites were collected using standard protocols. Both environmental and biological samples accumulated varying concentrations of the heavy metals. All the concentrations of the metals in environmental samples were lower than the target values, whereas concentrations of all the metals in the biological samples exceeded the permissible limits. Seventeen parasite species were recovered from infected hosts and included nematodes, trematodes, cestodes, pentastomids, and acanthocephalan cysts. Pearson’s correlation coefficients were computed for pairs of heavy metal concentrations in the environmental and biological samples with the parasite burdens and the results revealed among other findings that the lung trematodes, Haematoloechus exoterorchis and H. micrurus , correlated significantly positively with Cu in the soil samples and negatively with Pb and Cd in lungs and Cr in soil. This reflects the conditions that favour and hinder the ability of the parasites to establish infection in their host specimens.
Trends and Progress in Research on Intellectual Capital Disclosures in the Indian Context

Article History Intellectual capital is essential to enable firms to remain competitive. It represents the future earning potential of the company and is of great value to investors, analysts and stockholders. In India, the disclosure of intellectual capital is at a nascent stage and so it the research related to intellectual disclosure. This paper aims to examine the research examining intellectual disclosure in the Indian context and identifies avenues for research in the domain.
Astrocytes Are Protective Against Chlorpyrifos Developmental Neurotoxicity in Human Pluripotent Stem Cell-Derived Astrocyte-Neuron Cocultures

Human neural progenitor cells are capable of independent, directed differentiation into astrocytes, oligodendrocytes and neurons and thus offer a potential cell source for developmental neurotoxicity (DNT) systems. Human neural progenitor-derived astrocyte-neuron cocultured at deﬁned ratios mimic cellular heterogeneity and interaction in the central nervous system. Cytochrome P450 enzymes are expressed at a relatively high level in astrocytes and may play a critical role in the biotransformation of endogenous or exogenous compounds, including chlorpyrifos, an organophosphate insecticide that affects the central nervous system. P450 enzymes metabolize chlorpyrifos to chlorpyrifos-oxon, which is then metabolized primarily to 3, 5, 6-trichloropyridinol in addition to diethylphosphate and diethylthiophosphate. These end metabolites are less neurotoxic than chlorpyrifos and chlorpyrifos-oxon. Our objective was to identify the interactive role of astrocytes and neurons in chlorpyrifos-induced human DNT. In neuron-only cultures, chlorpyrifos inhibited neurite length, neurite number and branch points per neuron in a dose-dependent manner during a 48h exposure, starting at 10 l M. However, in astrocyte-neuron cocultures, astrocytes protected neurons from the effects of chlorpyrifos at higher concentrations, up to and including 30 l M chlorpyrifos and endogenous astrocyte P450 enzymes effectively metabolized chlorpyrifos. The P450 inhibitor SKF525A partly negated the protective effect of astrocytes, allowing reduction in branch points with chlorpyrifos (10 l M). Thus, the scalable and deﬁned astrocyte-neuron cocultures model that we established here has potentially identiﬁed a role for P450 enzymes in astrocytic neuroprotection against chlorpyrifos and provides a novel model for addressing DNT in a more accurate multicellular environment.
Epstein-Barr Virus-Induced Resistance to Drugs That Activate the Mitotic Spindle Assembly Checkpoint in Burkitt’s Lymphoma Cells (cid:1) cell lines

Epstein-Barr virus (EBV) is associated with a number of human cancers, and latent EBV gene expression has been reported to interfere with cell cycle checkpoints and cell death pathways. Here we show that latent EBV can compromise the mitotic spindle assembly checkpoint and rescue Burkitt’s lymphoma (BL)-derived cells from caspase-dependent cell death initiated in aberrant mitosis. This leads to unscheduled mitotic progression, resulting in polyploidy and multi- and/or micronucleation. The EBV latent genes responsible for this phenotype are expressed from the P3HR1 strain of virus and several viruses with similar genomic deletions that remove the EBNA2 gene. Although EBNA2 and the latent membrane proteins are not expressed, the EBNA3 proteins are present in these BL cells. Survival of the EBV-positive cells is not consistently associated with EBV lytic gene expression or with the genes that are expressed in EBV latency I BL cells (i.e., EBNA1, EBERs, and BARTs) but correlates with reduced expression of the cellular proapoptotic BH3-only protein Bim. These data suggest that a subset of latent EBV gene products may increase the likelihood of damaged DNA being inherited because of the impaired checkpoint and enhanced survival capacity. This could lead to greater genetic diversity in progeny cells and contribute to tumorigenesis. Furthermore, since it appears that this restricted
Decentralized Meta Frank Wolfe for Online Neural Network Optimization

—The design of decentralized learning algorithms is important in the fast-growing world in which data are distributed over participants with limited local computation resources and communication. In this direction, we propose an online algorithm minimizing non-convex loss functions aggregated from individual data/models distributed over a network. We provide the theoretical performance guarantee of our algorithm and demonstrate its utility on a real life smart building.
Can rational sticky-price models explain

The canonical in(cid:13)ation speci(cid:12)cation in sticky-price rational expectations models (the new-Keynesian Phillips curve) is often criticized on the grounds that it fails to account for the dependence of in(cid:13)ation on its own lags. In response, many recent studies have employed a \hybrid" sticky-price speci(cid:12)cation in which in(cid:13)ation depends on a weighted average of lagged and expected future values of itself, in addition to a driving variable such as the output gap. In this paper, we consider some simple tests of the hybrid model that are derived from the model’s closed-form solution. Our results suggest that the hybrid model provides a poor description of empirical in(cid:13)ation dynamics, and that there is little evidence of the type of rational forward-looking behavior implied by the model.
PON1 de ciency promotes TREM2 pathway- mediated microglial phagocytosis and inhibits LPS- induced pro-in ammatory cytokines release

lianfeng zhang (  zhanglf@cnilas.org ) Chinese Academy of Medical Sciences Institute of Laboratory Animal Sciences https://orcid.org/00000002-5774-2924 Li Zhang Chinese Academy of Medical Sciences Institute of Laboratory Animal Sciences Wei Dong Chinese Academy of Medical Sciences Institute of Laboratory Animal Sciences Yuanwu Ma Chinese Academy of Medical Sciences Institute of Laboratory Animal Sciences Lin Bai Chinese Academy of Medical Sciences Institute of Laboratory Animal Sciences Xu Zhang Chinese Academy of Medical Sciences Institute of Laboratory Animal Sciences Caixian Sun Chinese Academy of Medical Sciences Institute of Laboratory Animal Sciences Jingwen Li Chinese Academy of Medical Sciences Institute of Laboratory Animal Sciences
VHRM_A_327661 601..617

1Department of Cardiology and Cardiovascular Surgery, Samara State Medical University, Samara, 443099, Russia; 2Department of Histology and Embryology, Samara State Medical University, Samara, 443099, Russia Abstract: The causes and mechanisms of increased cardiac troponin T and I (cTnT and cTnI) concentrations are numerous and are not limited to acute myocardial infarction (AMI) (ischemic necrosis of cardiac myocytes). Any type of reversible or irreversible cardiomyocyte injury can result in elevated serum cTnT and cTnI levels. Researchers and practitioners involved in the diagnosis and treatment of cardiovascular disease, including AMI, should know the key causes and mechanisms of elevated serum cTnT and cTnI levels. This will allow to reduce or completely avoid diagnostic errors and help to choose the most correct tactics for further patient management. The purpose of this article is to discuss the main causes and mechanisms of increase in cardiac troponins concentrations in frequently occurring physiological (physical exertion, psycho-emotional stress) and pathological conditions (inflammatory heart disease, pulmonary embolism, chronic renal failure and sepsis (systemic inflammatory response)) not related to myocardial infarction.
Is there an association of asthma with dental caries and molar incisor 1 hypomineralisation? 2

This epidemiological study aimed to compare the caries and molar incisor hypomineralisation 35 (MIH) experience in asthmatic and non-asthmatic adolescents assessed at 10 and 15 years of 36 age. 7 30 adolescents from ongoing birth cohort studies (GINIplus / LISA) from Munich were 37 examined for carious lesions at the age of 10 and 15 to determine the caries experience under 38 inclusion of non-cavitated carious lesions D 1-2 T and the tooth-related decay-missing-filled 39 (DMFT) index. Furthermore, MIH was scored on all permanent teeth according to the criteria of 40 the European Academy of Paediatric Dentistry. The association of caries and MIH prevalence at 41 the 10-year and 15-year follow-up as well as caries incidence with ever having an asthma 42 diagnosis was analysed using hurdle regression models adjusted for potential confounders. Of 43 the 730 adolescents, 52 and 78 were identified as asthmatics at the 10- and 15-year follow-up, 44 respectively. There were no significant differences in caries prevalence or experience between 45 asthma-free participants and any of the asthma groups (taking metered-dose inhaler (MDI) 46 medication vs. taking no MDI medication). However, a significant, positive association was 47 found for asthmatic adolescents who did not take MDI medication with higher MIH/T values 48 (OR=2.56, 95%CI=1.03-6.37, p=0.043) compared to non-asthmatics. In conclusion, asthma did 49 not influence the caries status of adolescents in the present study. Interestingly, a significant 50 association was found for adolescents with asthma who did not take MDI medication and the 51 number of MIH-affected teeth. The association between asthma, medication and MIH needs 52 further confirmation. 53
Prevalence and Predictors of Sarcopenia Among Older Buddhist Monks in Thailand

: Sarcopenia is a progressive loss of musculoskeletal condition, and the Asian Working Group for Sarcopenia has established the following diagnostic criteria for sarcopenia: ( 1 ) handgrip strength (< 26 kg) and/or ( 2 ) gait speed (< 0.8 meter/second) and ( 3 ) skeletal muscle mass index (< 7 kg/m 2 ). Sarcopenia is known to have a negative impact on quality of life, including falls and progressive disability. Older Buddhist monks may be at a higher risk for sarcopenia because of dietary problems, low levels of exercise, and chronic illnesses. This study used a descriptive correlational design aiming to investigate the prevalence of sarcopenia and the predictability of this and its three components in 324 older monks in Bangkok and a surrounding province. Measures for data collection were demographic and health questionnaires containing 13 questions, and measures of body composition, muscle strength, and physical performance . Data analysis included descriptive statistics, logistic regression, and multiple linear regression. Results revealed that the prevalence of sarcopenia was zero. All participants had a normal skeletal muscle mass index; however, 31.2% had low handgrip strength; and 55.2% had low gait speed. Age and physical activity together predicted low handgrip strength. Age and chronic illness together predicted low gait speed. Body mass index, physical activity, and weight loss together predicted skeletal muscle mass index. Age and physical activity are strongly predictability with the components of sarcopenia, and nurses should promote moderate to vigorous physical activity for maintaining muscle strength and gait ability. 24(3) 363-375
Misery Is Not Miserly The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters

Misery is not miserly: sadness increases the amount of money decision makers give up to acquire a commodity (Lerner, Small, & Loewenstein, 2004). The present research investigated when and why the “misery-is-not-miserly” effect occurs. Drawing on William James’s (1890) concept of the material self, we tested a model specifying relationships among sadness, self-focus, and the amount of money decision makers spend. Consistent with our Jamesian hypothesis, results revealed that self-focus both moderates and mediates the effect of sadness on spending. Results were consistent across males and females. Because the study used real commodities and real money, results hold implications for everyday decisions. They also hold implications for theoretical development. Economic theories of spending may benefit from incorporating psychological theories – specifically theories of emotion and the self.
FEASA: AN APPROACH TO RESOLVE SENTIMENT AND GENERATE FEATURE EXTRACTION MATRIX

Sentiment analysis is the study of classifying human’s sentiments, evaluations, attitudes, opinions about some topic, product, expressed in form of text or speech. As e-commerce is becoming more and more popular, the number of customer reviews that a product receives grows rapidly. For a popular product, the number of reviews can be in hundreds or even thousands. This makes it difficult for a potential customer to read them to make an informed decision on whether to purchase the product. In order to improve the customer satisfaction, many e-commerce sites provides the provision to write reviews about products. Instead of manually reading and evaluating numerous reviews, an automated procedure can be helpful and can be easy to get the overall polarity of the reviews for the product. The goal of the research is to present an approach with the target of deriving qualitative sentiment analysis which will be helpful for recommendation. This paper introduces the FEASA (Feature extraction and sentiment analysis), an approach to resolve sentiment and generate feature extraction matrix for each product. FEM will help in determining the features, being commented upon and also help in detecting the popular features among the reviews. The paper aims at mining sentiment for each product review and summarizes overall sentiment score associated with each product review. The efficient ranking of the features will be deduced, based on the opinions.
THE ABUNDANCE OF X-SHAPED RADIO SOURCES: IMPLICATIONS FOR THE GRAVITATIONAL WAVE BACKGROUND

Coalescence of supermassive black holes (SMBHs) in galaxy mergers is potentially the dominant contributor to the low frequency gravitational wave background (GWB). It was proposed by Merritt & Ekers that X-shaped radio galaxies are signposts of such coalescences and that their abundance might be used to predict the magnitude of the GWB. In Roberts et al. we presented radio images of all 52 X-shaped radio source candidates out of the sample of 100 selected by Cheung for which archival VLA data were available. These images indicate that at most 21% of the candidates might be genuine X-shaped radio sources that were formed by a restarting of beams in a new direction following a major merger. This suggests that fewer than 1.3% of extended radio sources appear to be candidates for genuine axis reorientations (“spin flips”), much smaller than the 7% suggested by Leahy & Parma. Thus, the associated GWB may be substantially smaller than previous estimates. These results can be used to normalize detailed calculations of the SMBH coalescence rate and the GWB.
Released Protein Having Homology with the Human Platelet Surface Protein GPIbot

In Yersinia pestis KIM, there are 11 Yops (yersinial outer membrane proteins) encoded by the low-Ca2+ response virulence plasmid pCD1. Only Yops M and N are found in easily detectable amounts in the culture medium. In this study, we located and characterized theyopM gene to obtain clues about its role in the virulence of Y. pestis. Rabbit antibody was raised against Yops M and H, copurified from the supernatant of Y. pseudotuberculosis 43(pGW600, pCD1 yopE::Mu dIl[Apr lac]). This antiserum was adsorbed with an Escherichia coli clone that strongly expressed YopH. The resulting YopM-specific antibody was used to screen a HindIII library of pCD1. HindIII-F and several subclones from it expressed YopM in E. coli minicells. A DNA fragment of 1.39 kilobases from HindIII-F was sequenced and found to contain a 367-amino-acid open reading frame capable of encoding a protein with molecular mass (41,566 daltons) and isoelectric point (4.06) similar to those of YopM. The + 1 site of the yopM gene was determined by primer extension. The DNA sequence contained repeating structures: 11 pairs of exact direct repeats, two exact inverted repeats, and three palindromes, ranging from 10 to 42 bases in size. One consensus 14-amino-acid sequence was repeated six times
Nuclear norm subspace identification of innovation models

The identiﬁcation of multivariable state space models in innovation form is solved in a subspace identiﬁcation framework using convex nuclear norm optimization. The convex optimization approach allows to include constraints on the unknown matrices in the data-equation characterizing subspace identiﬁcation methods, such as the lower triangular block-Toeplitz of weighting matrices constructed from the Markov parameters of the unknown observer. The classical use of instrumental variables to remove the inﬂuence of the innovation term on the data equation in subspace identiﬁcation is avoided. The avoidance of the instrumental variable projection step has the potential to improve the accuracy of the estimated model predictions, especially for short data length sequences