Miracle-dz/UniFAR-FTUs huggingface dataset:
An evolvable hardware chip for prosthetic hand controller

This paper describes an Evolvable Hardware (EHW) chip, and the application of this chip as a controller for a myoelectric prosthetic hand. The chip consists of Genetic Algorithm (GA) hardware, reconfigurable hardware logic, a chromosome memory, a training data memory, and a 16-bit CPU core (NEC V30). This paper also briefly introduces other EHW chips being developed as part of the Ministry of International Trade and Industry's (MITI) Real World Computing Project (RWCP), which include an analogue EHW chip for cellular phones, a neural network EHW chip capable of autonomous reconfiguration, and a data compression EHW chip for electrophotographic printers.
Human Vγ9Vδ2 T Lymphocytes in the Immune Response to P. falciparum Infection

Malaria is an infectious disease caused by the protozoan parasite Plasmodium sp, the most lethal being Plasmodium falciparum. Clinical malaria is associated with the asexual replication cycle of Plasmodium parasites inside the red blood cells (RBCs) and a dysregulated immune response. Although the mechanisms of immune responses to blood—or liver-stage parasites have been extensively studied, this has not led to satisfactory leads for vaccine design. Among innate immune cells responding to infection are the non-conventional gamma-delta T-cells. The Vγ9Vδ2 T-cell subset, found only in primates, is activated in response to non-peptidic phosphoantigens produced by stressed mammalian cells or by microorganisms such as Mycobacteria, E.coli, and Plasmodium. The potential protective role of Vγ9Vδ2 T-cells against infections and cancer progression is of current research interest. Vγ9Vδ2 T-cells have been shown to play a role in the early control of P. falciparum parasitemia and to influence malaria adaptive immunity via cytokine release and antigen presentation. They are activated and expanded during a primary P. falciparum infection in response to malaria phosphoantigens and their activity is modulated upon subsequent infections. Here, we review the wide range of functions by which Vγ9Vδ2 T-cells could both contribute to and protect from malaria pathology, with a particular focus on their ability to induce both innate and adaptive responses. We discuss how the multifunctional roles of these T-cells could open new perspectives on gamma-delta T-cell-based interventions to prevent or cure malaria.
Virtual viewpoint synthesis in multi-view video system

In this paper, we present a virtual viewpoint video synthesis algorithm to satisfy the following three aims: low computing consuming; real time interpolation and acceptable video quality. In contrast with previous technologies, this method obtain incompletely 3D structure using neighbor video sources instead of getting total 3D information with all video sources, so that the computation is reduced greatly. So we demonstrate our interactive multi-view video synthesis algorithm in a personal computer. Furthermore, adopting the method of choosing feature points to build the correspondence between the frames captured by neighbor cameras, we need not require camera calibration. Finally, our method can be used when the angle between neighbor cameras is 25-30 degrees that it is much larger than common computer vision experiments. In this way, our method can be applied into many applications such as sports live, video conference, etc.
DNA Aptamers for the Functionalisation of DNA Origami Nanostructures

DNA origami has emerged in recent years as a powerful technique for designing and building 2D and 3D nanostructures. While the breadth of structures that have been produced is impressive, one of the remaining challenges, especially for DNA origami structures that are intended to carry out useful biomedical tasks in vivo, is to endow them with the ability to detect and respond to molecules of interest. Target molecules may be disease indicators or cell surface receptors, and the responses may include conformational changes leading to the release of therapeutically relevant cargo. Nucleic acid aptamers are ideally suited to this task and are beginning to be used in DNA origami designs. In this review, we consider examples of uses of DNA aptamers in DNA origami structures and summarise what is currently understood regarding aptamer-origami integration. We review three major roles for aptamers in such applications: protein immobilisation, triggering of structural transformation, and cell targeting. Finally, we consider future perspectives for DNA aptamer integration with DNA origami.
On the Interaction Between Joint Tx/Rx IQI and Channel Estimation Errors in DVB-T Systems

Digital video broadcasting terrestrial (DVB-T) systems use hierarchical modulation, which involve a “high-priority” and a “low-priority” (LP) bit stream. An inherent weakness of this scheme is the severe performance degradation of the less protected LP stream. In addition, the presence of inphase quadrature imbalance (IQI) at both transmitter/receiver front end may significantly reduce the detection accuracy. Here, we propose an improved receiver design for OFDM-based DVB-T systems confronting the effects of both imperfect channel estimation and IQI. First, we propose a specific pilot-symbol arrangement inside the OFDM symbol that facilitates derivation of the posterior distribution of the perfect channel conditioned on its maximum-likelihood (ML) estimate. The latter posterior distribution plays an important role toward an improved receiver design for taking into account channel estimation errors in the presence of IQI at the receiver side. Second, we derive the formulation of an improved and efficient detector under channel estimation errors when IQI is also present only at the receiver side. Third, we generalize our proposed improved detector for the case where IQI is present at both transmitter and receiver sides. The proposed approach is able to reduce the impact of channel uncertainty on the receiver's performance in the presence of IQI. Our results are compared to those achieved by the conventional mismatched ML detector, which uses the imperfect channel as perfect channel and to those obtained by the detector based on the expectation-maximization algorithm. Numerical results over a realistic COST 207 channel model show that significant performance improvement is achieved for bit error rate of the LP stream in the considered DVB-T system.
Fully Integrated Asymmetric Doherty Amplifier Based on Two-Power-Level Impedance Optimization

A fully integrated asymmetric Doherty power amplifier has been developed by using GaN HEMT MMIC technology. To minimize the circuit size, a two-power-level impedance optimization method was applied instead of using a quarter-wavelength transmission line impedance inverter for load modulation in the Doherty amplifier. For this optimization, asymmetric configuration is required to realize optimum impedance conditions. The 4-GHz-band GaN HEMT Doherty amplifier MMIC exhibited a maximum drain efficiency of 56% and a maximum power-added efficiency (PAE) of 53% at 4.3 GHz, with a saturation output power of 36dBm. In addition, PAE of 44% was achieved at 4.2 GHz on a 6-dB output back-off condition.
Subchronic treatment with St John’s wort produces a positive shift in emotional processing in healthy volunteers

Background: The neurocognitive model of antidepressant treatment in depression states that antidepressants work by producing relatively immediate positive shifts in emotional processing, which translate into clinical improvement with time. St John’s Wort has shown antidepressant potential in randomised controlled trials; however, its pharmacological actions are broad and it is unknown whether treatment also produces changes in emotional processing. Aims: We investigated whether short-term treatment with St John’s wort has similar effects on emotional processing to those reported with other antidepressants such as selective serotonergic reuptake inhibitors. Methods: Forty-eight healthy participants were given St John’s wort or placebo treatment for seven days. On day 7 they completed a battery of tasks to measure emotional processing and other elements of cognition. Results: St John’s wort treatment produced similar changes to other antidepressants, for example reducing recognition of disgusted faces and attention to fearful faces, while increasing memory for positive words. We failed to find evidence for an effect of St John’s wort on other aspects of cognition including working memory. Conclusions: These findings lend support to the theory that the production of early positive biases in emotional processing may be a common feature of all clinically effective antidepressants with diverse pharmacological mechanisms.
Multimodel Substance Use Intervention Program for Male Delinquents

ABSTRACT In this prevention-early intervention project, for inner-city, low SES, court-adjudicated male adolescents, conducted in a residential treatment center, new admissions were randomly assigned to either a program participant group (in a triple-modality social learning program in the classroom), or to a control group. Results: The follow-up assessment (N = 251), at six months after discharge to home and community, showed that the program group reported a significantly greater degree of reduction in drug use/abuse, and in the selling of drugs, but not in alcohol use, or in illegal violent behavior, or in school problems. By means of dosage and process analyses, it was determined that (1) it was the Botvin LST program that was effective in reducing substance use/abuse and the selling of drugs; and (2) that those participants who participated more positively in the Prothrow-Stith Anti-Violence program reduced their violent behavior at follow-up to a significantly greater degree.
Navigation of a car-like mobile robot using a decomposition of the environment in convex cells

A method for rapidly computing the possible maneuvers of car-like robots within convex polygonal cells is presented. In a convex polygonal cell, maneuvering can be completely handled with geometric reasoning, and, since only a few boundary configurations have to be checked to avoid collision, the method allows precise computation of the maneuvers without using the whole configuration space. General environments are then described by means of a graph connecting overlapping convex cells. To find a path to a goal, the graph is searched to determine the cells that have to be traversed. Intermediate configurations are then computed inside the intersection of each pair of adjacent cells. Finally, the trajectories generated inside each cell are assembled to produce global collision-free paths in complex environments. <<ETX>>
For Love or Money? Gender Differences in How One Approaches Getting a Job

Extant supply-side labor market theories conclude that women and men apply to different jobs but are unable to explain gender differences in how they may be have when applying to the same job. We correct this discrepancy by considering gendered approaches to the hiring process. We propose that applicants can emphasize either the relational or the transactional aspects of the job and that this affects whether they are hired. Relational job seekers focus on developing a social connection with their employer. In contrast, transactional job seekers focus on quantitative and mechanical aspects of the job. We expect women to be more relational and men to be more transactional and that this behavior will contribute to differences in hiring outcomes. Specifically, we contend that being relational suggest that one is more committed to the job at hand and therefore should increases the chances of being hired – holding constant competence. We examine behaviors in an online contract labor market for graphic designers, Elance.com where we find that women are more likely to be hired than men by about 4.1%. Quantitative linguistic analysis on the unstructured text of job proposals reveals that women (men) adopt more relational (transactional) language in their applications. These different approaches affect a job seeker’s likelihood of being hired and attenuate the gender gap we identified. Attenuation suggests that how one approaches the hiring process matters and that gender is correlated with a particular style of engagement.
Roux-en-Y Gastric Bypass Surgery Induces Distinct but Frequently Transient Effects on Acylcarnitine, Bile Acid and Phospholipid Levels

Roux-en-Y gastric bypass (RYGB) is an effective method to achieve sustained weight loss, but the mechanisms responsible for RYGB effects have not yet been fully characterized. In this study, we profiled the concentrations of 143 lipid metabolites in dry blood spots (DBS) of RYGB patients. DBS from obese patients (BMI range 35–44 kg/m2) were collected 7 days before, 15 and 90 days after the surgery. LC-MS/MS was used to quantify acylcarnitines, phosphatidylcholines, sphingomyelins and bile acids. RYGB caused a rapid increase in acylcarnitine levels that proved to be only transient, contrasting with the sustained decrease in phosphatidylcholines and increase of sphingomyelins and bile acids. A PLS-DA analysis revealed a 3-component model (R2 = 0.9, Q2 = 0.74) with key metabolites responsible for the overall metabolite differences. These included the BCAA-derived acylcarnitines and sphingomyelins with 16 and 18 carbons. We found important correlations between the levels of BCAA-derived acylcarnitines and specific sphingomyelins with plasma cholesterol and triacylglycerol concentrations. Along with the marked weight loss and clinical improvements, RYGB induced specific alterations in plasma acylcarnitines, bile acid and phospholipid levels. This calls for more studies on RYGB effects aiming to elucidate the metabolic adaptations that follow this procedure.
On the Evaluation of an Entropy-Based Spectrum Sensing Strategy Applied to Cognitive Radio Networks

In this paper, the evaluation of a spectrum sensing strategy based on the frequency domain entropy applied to cognitive radio networks is presented. Entropy estimation is performed using Bartlett periodogram. A tradeoff between variance and the spectral resolution for Bartlett periodogram is presented. This tradeoff affects the probability of detection and false alarm of the spectrum sensing strategy in environments with low signal-to-noise ratio and noise uncertainty. The Entropy detector is optimal when the product of the number of segments and the number of points used is equal to the number of available samples of the received signal.
Abstract 780: An EGFR inhibitor enhances the efficacy of SN38, an active metabolite of irinotecan, in SN38-refractory gastric carcinoma cells

Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Background: Acquired drug resistance to irinotecan is one of the significant obstacles in the treatment of advanced gastric cancer. This study was performed to clarify the effect of epidermal growth factor receptor (EGFR) inhibitors in combination with SN38, an active metabolite of irinotecan, on the proliferation of irinotecan-refractory gastric cancer. Methods: Two irinotecan-resistant gastric cancer cell lines, OCUM-2M/SN38 and OCUM-8/SN38, were respectively established by stepwise exposure to SN38 from the parent gastric cancer cell lines OCUM-2M and OCUM-8. The combination effects of two EGFR inhibitors, gefitinib and lapatinib, with SN38 on proliferation, apoptosis, and cell-cycle on gastric cancer cells were examined. Results: Gefitinib or lapatinib showed synergistic anti-tumor effects against OCUM-2M/SN38 and OCUM-8/SN38 cells when used in combination with SN38, but not against OCUM-2M or OCUM-8 cells. SN38 increased the expression of EGFR and HER2 in OCUM-2M/SN38 and OCUM-8/SN38 cells. The combination of an EGFR inhibitor and SN38 significantly increased the levels of apoptosis-related molecules, caspase-6, p53, and DAPK-2, and resulted in the induction of apoptosis of irinotecan-resistant cells. The EGFR inhibitors increased the S-phase and decreased the UGT1A1 and ABCG expression in irinotecan-resistant cells. The SN38 plus Lapatinib group more effectively suppressed in vivo tumor growth by OCUM-2M/SN38 cells than either alone group.Conclusion: The combination treatment with an EGFR inhibitor and irinotecan might produce synergistic anti-tumor effects for irinotecan-refractory gastric cancer cells. The regulation of SN38 metabolism-related genes and cell cycle by EGFR inhibitors might be responsible for the synergism. [Figure][1] Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 780. doi:1538-7445.AM2012-780 [1]: pending:yes
Unsupervised brain lesion segmentation from MRI using a convolutional autoencoder

Lesions that appear hyperintense in both Fluid Attenuated Inversion Recovery (FLAIR) and T2-weighted magnetic resonance images (MRIs) of the human brain are common in the brains of the elderly population and may be caused by ischemia or demyelination. Lesions are biomarkers for various neurodegenerative diseases, making accurate quantification of them important for both disease diagnosis and progression. Automatic lesion detection using supervised learning requires manually annotated images, which can often be impractical to acquire. Unsupervised lesion detection, on the other hand, does not require any manual delineation; however, these methods can be challenging to construct due to the variability in lesion load, placement of lesions, and voxel intensities. Here we present a novel approach to address this problem using a convolutional autoencoder, which learns to segment brain lesions as well as the white matter, gray matter, and cerebrospinal fluid by reconstructing FLAIR images as conical combinations of softmax layer outputs generated from the corresponding T1, T2, and FLAIR images. Some of the advantages of this model are that it accurately learns to segment lesions regardless of lesion load, and it can be used to quickly and robustly segment new images that were not in the training set. Comparisons with state-of-the-art segmentation methods evaluated on ground truth manual labels indicate that the proposed method works well for generating accurate lesion segmentations without the need for manual annotations.
X monosomy in the endangered Kiso horse breed detected by a parentage test using sex chromosome linked genes and microsatellites

A routine parentage test as part of a conservation program for Kiso horses identified a possible sex chromosome anomaly in a 7 months-old filly because of an aberrant result using LEX3, an X-linked marker. We then analyzed X-linked markers (LEX26, TKY38, and TKY270), Y-linked markers (Eca.YH12, Eca.YM2, Eca.YA16, and the sex-determining region Y gene), and an X/Y marker (Amelogenin gene). This analysis demonstrated that the filly had not inherited an X chromosome from her sire. A karyotyping analysis confirmed that the filly was 63,XO. As it was suspected that the horse would be sterile, we avoided using the horse as a broodmare; the information should also serve to prevent unnecessary conflict between owners transferring and receiving the horse.
Appliance Reader 3 1

Nowadays, almost all appliances are embedded with digital displays. Unfortunately, due to its non-tactile nature, digital display is impractical for blind/visually-impaired user. The goal of Appliance Reader project is to build a mobile application that aids blind/visuallyimpaired people reading digital display. Appliance Reader allows users to interpret the reading of a digital display by taking an image of the display using their smartphone. Using computer vision and machine learning algorithms over the images captured by the phone, the semantic of the display is interpreted and delivered to the user using text-to-speech engine.
Advancements in Curriculum and Assessment by the Use of IMMEX Technology in the Organic Laboratory

The use of web-based software and course management systems for the delivery of online assessments in the chemistry classroom is becoming more common. IMMEX software, like other web-based software, can be used for delivering assessments and providing feedback, but differs in that it offers additional features designed to give insights and promote improvements in problem solving strategies. This report describes some of the features offered with IMMEX software and provides a detailed description of how IMMEX problems are best implemented into the organic laboratory.
An Area Efficient Thermal Energy Harvester With Reconfigurable Capacitor Charge Pump for IoT Applications

This brief introduces an integrated energy harvester system targeting Internet of Things sensor applications such as a wireless temperature sensor. The proposed design provides 1-V regulated voltage boosting the input voltage (0.27–1 V) from a thermoelectric generator (TEG). To ensure the maximum power extraction, the proposed energy harvester includes multiple circuit level techniques. First, the reconfigurable capacitor charge pump distributes on-chip capacitors to required step-up stages. This approach optimizes the silicon area by utilizing 100% of on-chip capacitors regardless of charge pump conversion gain. Second, the design is capable of 3-D maximum power point tracking, matching a source impedance to input impedance of the energy harvester. Thus, the proposed design is able to extract power from a small form factor TEG, having low source impedance. The reconfigurable capacitor charge pump has the highest power density while delivering power up to <inline-formula> <tex-math notation="LaTeX">$500~{\mu W}$ </tex-math></inline-formula>. Experimental results show end-to-end power efficiency of 64% @ 1–V output voltage, and an input impedance matching range of <inline-formula> <tex-math notation="LaTeX">$1 {\Omega } - 5~{\mathbf{k}}{\Omega }$ </tex-math></inline-formula>. The energy harvester was fabricated in 130-nm CMOS standard technology with an active area of 0.835 mm<sup>2</sup>.
Research on Offline Storage of Web Page

Offline storage technology has many uses in the Web application and it can store the user status, cache data, temporary data, and persistent data and so on. In this paper several typical web client storage technologies are discussed and it includes the IE browser's unique storage technology UserData, localStorage and sessionStorage of HTML5, Web SQL Databases, Indexed Database, as well as classic storage technology Cookie and so on. Their concrete using methods are explained and their individual strengths and differences are compared. Their respective applications occasions and some issues that need attention are discussed. The general cross-browser offline storage method is presented and it can use the same application programming interface to complete different browser offline storage technologies.
Towards the Internet of Flying Robots: A Survey

The Internet of Flying Robots (IoFR) has received much attention in recent years thanks to the mobility and flexibility of flying robots. Although a lot of research has been done, there is a lack of a comprehensive survey on this topic. This paper analyzes several typical problems in designing IoFR for real applications, including wireless communication support, monitoring targets of interest, serving a wireless sensor network, and collaborating with ground robots. In particular, an overview of the existing publications on the coverage problem, connectivity of flying robots, energy capacity limitation, target searching, path planning, flying robot navigation with collision avoidance, etc., is presented. Beyond the discussion of these available approaches, some shortcomings of them are indicated and some promising future research directions are pointed out.