Miracle-dz/UniFAR-FTUs huggingface dataset:
CHAPTER 3 Measurably Superior lnstructional Methods : Do We Need Sales and Marketing ?

This chapter expands on previous discussions of the importance of taking a sales and marketing approach to the dissemination and promotion of effective instructional technology @inder & Wafins, 1989; Binder, 1.990, l99lq I991b). Betravioral edtrcators who have developed measurably effective instructional methods and materials mustdo a betterjob of targeting markets and customers, identifying their needso developing and packaging specific solutions for those needs, describing trcse offerings wifi language drat will influencecustomers' buying decisions, and inducing customers to adopt or literally purchase the solution. Stated rvith a more corrunercial intent, we need to learn how to package and promote what we do to sell it in sufficient quantity and generate sufficient revenues to guarantee continued, independent funding of our research and development. This is the most pressing challenge for instructional technologists today if we seek to make significant, Iasting contributions.
THE BIO-PSYCHO-SOCIAL ASPECTS OF OBSESSIVE COMPULSIVE DISORDER: A PRIMER FOR PRACTITIONERS

It is estimated that approximately 2.5% of the general population can be diagnosed as having Obsessive compulsive disorder (OCD). As a result, many practitioners will come into contact with clients exhibiting symptoms of OCD. This review presents a summary of diagnostic information, bio-psycho-social influences and treatment approaches regarding OCD which practitioners will find a helpful introduction to OCD thereby aiding professional practice. Also provided is a case example of how to perform cognitive-behavioral therapy for OCD. THE BIO-PSYCHO-SOCIAL ASPECTS OF OBSESSIVE COMPULSIVE DISORDER: A PRIMER FOR PRACTITIONERS Obsessive compulsive disorder (OCD) is an anxiety disorder that affects approximately 2-3% of the general population (Mental Health Association of New South Wales [MHANSW], 2006). It has been argued, however, that a figure of approximately 2.5% is an underestimate and thus OCD remains an undertreated diagnosis. The under-estimate can be explained by a number of factors, including social stigma, failure to identify symptoms or lacking a comprehensive understanding of the disorder (Abramowitz, 1997). Logically, a comprehensive knowledge of OCD and related factors will aid in the diagnosis and thus subsequent treatment of OCD. This literature review provides a comprehensive review of OCD and its related biological, psychological and sociological factors. Specifically, this approach will address OCD in accordance to diagnostic criteria, factors specific to the disorder from within a biopsycho-social framework, current treatment approaches as well as incidence and prognosis.
A Review of the Literature on Corruption in Healthcare Organizations

This paper provides a systematic and bibliometric review of 80 research articles on corruption in healthcare published in peer-reviewed journals between 2006 and 2017. Findings suggest that the number of studies has increased over time with a focus on low- and middle-income countries; academic researchers have published papers in a large variety of journals and have investigated different types of corruption with various methodologies. The interest is especially focused on low- and middle-income countries where corrupt behaviors are more common. The paper suggests future research directions to a dynamic research community to facilitate anticorruption actions by public authorities.
Intra-abdominal desmoid tumor on the back- ground of lynch syndrome. An unusual association mimicking recurrent colon cancer

Desmoid tumors are rare benign tumors that tend to be locally invasive rather than metastatic, and have a high recurrence rate despite complete excision [1]. Intra-abdominal desmoids are sporadic in most cases with only 20% associated with familial syndromes, in particular Familial Adenomatous Polyposis (FAP). Sporadic cases seem to be less aggressive and associated with a lower mortality and recurrence rate than FAP-associated desmoids [2]. The etiology is unknown, however, a history of previous trauma is sometimes identified [3]. Desmoid tumor diagnosis in the context of Hereditary Nonpolyposis Colorectal Cancer (HNPCCLynch syndrome) has not been previously deAbdulmohsin Aldilaijan1*; Mohammed Tahtouh1; Hassan Alzahrani2; Deena T Boqari3; Antonio Privitera1 1Department of Surgery, King Fahad Specialist Hospital-Dammam, Saudi Arabia 2Department of Medical imaging, King Fahad Specialist Hospital-Dammam, Saudi Arabia 3Department of Pathology, King Fahad Specialist Hospital-Dammam, Saudi Arabia
COVID-19 resources.

Remote Public Meetings Toolkit [1] WEBINAR: Remote Working Best Practices [2] (watch recorded webinar) Guidance and Resources from Partner Organizations [3] [4] What Does the Families First Coronavirus Response Act Mean for Municipalities? [4] Guidance and FAQs for "Stay Home, Stay Safe" [5] What Are Essential Local Government Services and Functions? [6] Open Meeting Law and COVID-19 FAQs [7] Open Meeting Law and COVID-19 Legislative Update [8] Town Finance COVID-19 FAQs [9] Town Office Closure COVID-19 FAQs [10] Human Resource Laws and COVID-19 FAQs [11] Cybersecurity – Especially Important for Remote Workers [12] Volunteer Risk Management: Best Practices and PACIF Coverage [13] Mutual Aid Agreement Sample for Sharing Resources Between Municipalities [14] Review and update your Local Emergency Plan [15] Vermont health insurers' COVID-19 web pages [16]
Protein Tyrosine Kinase-Dependent Modulation of Isoflurane Effects on Cardiac Sarcolemmal KATP Channel

Background Cardiac adenosine triphosphate-sensitive potassium (KATP) channels and protein tyrosine kinases (PTKs) are mediators of ischemic preconditioning, but the interaction of both and a role in myocardial protection afforded by volatile anesthetics have not been defined. Methods Whole cell and single channel patch clamp techniques were used to investigate the effects of isoflurane and the PTK inhibitor genistein on the cardiac sarcolemmal KATP channel in acutely dissociated guinea pig ventricular myocytes. Results At 0.5 mm internal ATP, genistein (50 &mgr;m) elicited whole cell KATP current (22.5 ± 7.9 pA/pF). Genistein effects were concentration-dependent, with an EC50 of 32.3 ± 1.4 &mgr;m. Another PTK inhibitor, tyrphostin B42, had a similar effect. The inactive analog of genistein, daidzein (50 &mgr;m), did not elicit KATP current. Isoflurane (0.5 mm) increased genistein (35 &mgr;m)- activated whole cell KATP current from 14.5 ± 3.1 to 32.5 ± 6.6 pA/pF. Stimulation of receptor PTKs with epidermal growth factor, nerve growth factor, or insulin attenuated genistein and isoflurane effects, and the protein tyrosine phosphatase inhibitor orthovanadate (1 mm) prevented their actions on KATP current. In excised inside-out membrane patches, and at fixed 0.2 mm internal ATP, genistein (50 &mgr;m) increased channel open probability from 0.053 ± 0.016 to 0.183 ± 0.039, but isoflurane failed to further increase open probability (0.162 ± 0.051) of genistein-activated channels. However, applied in the presence of genistein and protein tyrosine phosphatase 1B (1 &mgr;g/ml), isoflurane significantly increased open probability to 0.473 ± 0.114. Conclusions These results suggest that the PTK-protein tyrosine phosphatase signaling pathway may be one of the regulators of cardiac sarcolemmal KATP channel and may play a role in modulating its responsiveness to isoflurane. Relative importance of this modulation for cardioprotection by volatile anesthetics remains to be established.
Mapping the global potential transmission hotspots for severe fever with thrombocytopenia syndrome by machine learning methods

ABSTRACT Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with increasing spread. Currently SFTS transmission has expanded beyond Asian countries, however, with definitive global extents and risk patterns remained obscure. Here we established an exhaustive database that included globally reported locations of human SFTS cases and the competent vector, Haemaphysalis longicornis (H. longicornis), as well as the explanatory environmental variables, based on which, the potential geographic range of H. longicornis and risk areas for SFTS were mapped by applying two machine learning methods. Ten predictors were identified contributing to global distribution for H. longicornis with relative contribution ≥1%. Outside contemporary known distribution, we predict high receptivity to H. longicornis across two continents, including northeastern USA, New Zealand, parts of Australia, and several Pacific islands. Eight key drivers of SFTS cases occurrence were identified, including elevation, predicted probability of H. longicornis presence, two temperature-related factors, two precipitation-related factors, the richness of mammals and percentage coverage of water bodies. The globally model-predicted risk map of human SFTS occurrence was created and validated effective for discriminating the actual affected and unaffected areas (median predictive probability 0.74 vs. 0.04, P < 0.001) in three countries with reported cases outside China. The high-risk areas (probability ≥50%) were predicted mainly in east-central China, most parts of the Korean peninsula and southern Japan, and northern New Zealand. Our findings highlight areas where an intensive vigilance for potential SFTS spread or invasion events should be advocated, owing to their high receptibility to H. longicornis distribution.
Design, Synthesis and Biological Evaluation of Quinazolin-4-one Based Hydroxamic Acids as Dual PI3K/HDAC Inhibitors.

A series of quinazolin-4-one based hydroxamic acids was rationally designed and synthesized as novel dual PI3K/HDAC inhibitors by incorporating an HDAC pharmacophore into a PI3K inhibitor (Idelalisib) via an optimized linker. Several of these dual inhibitors were highly potent (IC50 < 10 nM) and selective against PI3Kγ, δ and HDAC6 enzymes, and exhibited good anti-proliferative activity against multiple cancer cell lines. The lead compound 48c, induced necrosis in several mutant and FLT3-resistant AML cell lines and primary blasts from AML patients, while showing no cytotoxicity against normal PBMCs, NIH3T3 and HEK293 cells. Target engagement of PI3K and HDAC6 by 48c was demonstrated in MV411 cells using the Cellular Thermal Shift Assay (CETSA). Compound 48c showed good pharmacokinetics properties in mice via intraperitoneal (ip) administration and provides a means to examine the biological effects of inhibiting these two important enzymes with a single molecule, either in vitro or in vivo.
Ultrasound-guided “Low Approach” Femoral Vein Catheterization in Critical Care Patients Results in High Incidence of Deep Vein Thrombosis

before insertion, and the whole length of the catheter was then inserted through the endotracheal tube adapter. On postoperative removal, the distal segment became separated completely and was left behind within the endotracheal tube. Routine endotracheal suctioning may then have led to migration of the catheter into the distal airway. It is also possible that the catheter snapped at the junction with the hub upon removal, because this junction is usually considered a weak point. Unfortunately, there is no documentation of the length to which the catheter was trimmed before insertion to decide which mechanism was most likely. This case demonstrates an important complication of distal end-tidal carbon dioxide monitoring in the very low-birth-weight infant and reemphasizes the dangers of using catheters that were not developed for use in this population. Because there are no custom-made catheters for this population, it does emphasize the need to ensure that if a catheter is cut, the distal end should be accounted for and appropriately disposed of. It particularly stresses the importance of measuring the length to which the catheter is cut before insertion, and the need to remeasure catheter length upon removal. It also emphasizes the need to review all aspects of the x-ray, in particular the status of indwelling tubes and line. Dana Al-Nabhani, M.D., Sandesh Shivananda, M.D., D.M. , Helen Holtby, M.B. , B.S., F.R. C.P.(C). , Patrick J. McNamara, M.B. , B.Ch., M.Sc., M.R. C.P.C.H. * *The Hospital for Sick Children Research Institute and the University of Toronto, Toronto, Canada. patrick.mcnamara@sickkids.ca
Quality of life and psychological functioning in postmenopausal women undergoing aromatase inhibitor treatment for early breast cancer

Introduction Aromatase inhibitors (AIs) dramatically increased breast cancer (BC) survival, leading to enhanced attention to their long-term consequences on psychological functioning. Conflicting data has been examined regarding the association between AIs administration and the clinical psychological features in BC survivors (BCSs). Purpose As psychological symptoms often occur in such chronic diseases, our study aimed at exploring anxious and depressive symptoms and the perceived quality of life (QoL) in BCSs assessed for osteoporosis. Methods The total sample consisted of a clinical sample of 51 outpatient postmenopausal women, diagnosed with BC, and a control group composed of 51 healthy postmenopausal women. All recruited participants were evaluated through the clinical gold standard interview and completed the following self-rating scales: the Hamilton Anxiety Rating Scale, Beck Depression Inventory II edition, and 36-Item Short Form Health Survey, which were administered at baseline and after 6 months in BCSs in AIs treatment, compared with controls. Moreover, all participants were assessed for vitamin D status, bone mineral density (BMD) and subclinical vertebral fractures. Data regarding age, age at menopause, body mass index (BMI), smoking habits and alcohol consumption was collected. Results BCSs (n = 51) showed higher anxious and depressive symptoms, and lower perceived QoL vs. controls (n = 51) (p<0.05 for all). After 6 months of treatment with AIs, BCSs showed significant reduction of anxious and depressive symptoms and a significantly higher perceived QoL for both physical and mental components, vs. controls. Conclusions The improvement of clinical psychological features and perceived QoL was associated with AIs treatment in women being treated with, for early breast cancer. Further studies are needed to obtain a deeper comprehension of the correlation between clinical psychological and physical features in BCSs.
[Efficacy and safety of low-intensity extracorporeal shock wave therapy in the treatment of ED: A meta-analysis of randomized controlled trials].

Objective To evaluate the clinical efficacy and safety of low-intensity extracorporeal shock wave therapy (LI-ESWT) in the treatment of ED based on the available clinical evidence. METHODS We searched PubMed, MEDLINE, EMBASE, Cochrane Library, CNKI, VIP, CBM and Wanfang Database up to June 2018 for published randomized controlled trials on the treatment of ED by LI-ESWT. We performed literature screening, data extraction and quality evaluation according to inclusion and exclusion criteria, and conducted a meta-analysis of the data obtained using the RevMan 5.3 software. RESULTS A total of 595 ED cases in 8 double-blind randomized controlled trials (RCT) were included in this study, 362 in the LI-ESWT and 233 in the control group. Compared with the controls, the patients treated by LI-ESWT showed significantly improved IIEF (WMD = 1.70, 95% CI: 0.44－2.96, P = 0.008) and erection hardness score (EHS) (RR = 11.72, 95% CI: 5.13－26.80, P < 0.01). The IIEF scores of the patients were markedly increased at 4 and 24 weeks after LI-ESWT (WMD = 1.43, 95% CI: 0.10－2.75, P = 0.03; WMD = 3.09, 95% CI: 1.49－4.68, P = 0.0002), as well as after the 10th to 12th treatment (WMD = 1.81, 95% CI: 0.31－3.31, P = 0.02) though not after the 5th to 6th (WMD = 1.88, 95% CI: －2.10 to 5.86, P = 0.35). LI-ESWT also significantly increased the IIEF scores in the patients with the baseline IIEF ≥12 (WMD = 2.13, 95% CI: 0.51－3.75, P = 0.01) but not in those with the baseline IIEF ≤11 (WMD = 1.04, 95% CI: －0.96 to 3.03, P = 0.31). No significant adverse events were reported in the 8 RCTs. CONCLUSIONS As a non-invasive treatment, LI-ESWT is safe and effective and can significantly improve IIEF and EHS in ED patients.
A systematic review on different models of inducing obesity in animals: Advantages and limitations

Several animals have been in the limelight of basic research associated with metabolic diseases like obesity. Obesity can be considered as a significant public health concern in the world. It raises the chances for a variety of disease conditions that includes diabetes, hypertension, liver disease, and cancers, which, in turn, decreases the overall lifespan of adult men and women. The World Health Organization has considered obesity as a global epidemic. Researchers have made several attempts to classify human obesity, but none have been successful. Animal obesity can be classified based on their etiology; however, till now, no animal model of obesity can replicate models of the human condition, they have only provided clues into the causes, aftermaths, and preventive remedy to human adiposity. Over the years, there are varieties of animal models used to induce obesity. Some of them include monogenic, polygenic, surgical, seasonal, and other models of obesity. Apart from the advantages of these models, most of them are accompanied by limitations. The primary purpose of this review is, therefore, to highlight the several models with their advantages and limitations. By knowing the benefits and limitations of animal models of obesity, researchers may be at liberty to select the appropriate one for the study of obesity.
Criterion-referenced mCAFT cut-points to identify metabolically healthy cardiorespiratory fitness among adults aged 18-69 years: An analysis of the Canadian Health Measures Survey.

OBJECTIVE This study aimed to develop and validate health-related criterion-referenced cut-points for the modified Canadian Aerobic Fitness Test (mCAFT), a field-based measure to predict cardiorespiratory fitness (CRF) among adults (18-69 years). METHODS Criterion-referenced mCAFT cut-points were developed using nationally representative data from cycles 1 (2007-09) and 2 (2009-11) of the Canadian Health Measures Survey (CHMS). Receiver operating characteristic curves were used to identify age- and sex-specific cut-points for measured waist circumference, blood pressure, and high-density lipoprotein. Cut-points were validated against metabolic syndrome using a fasted sub-sample (n=1,093) from cycle 5 (2016-17). RESULTS 4,967 participants (50% women) were retained for the main analyses. The mCAFT cut-points ranged from 28 to 43 mL•kg-1•min-1 (AUC: 0.60-0.87) among men, and 23 to 37 mL•kg-1•min-1 (AUC: 0.61-0.86) among women. The likelihood of meeting the new mCAFT cut-points decreased with an increase in the presence of metabolic risk factors. In total, 54% (95%CI: 42 to 67%) of Canadian adults met the new mCAFT cut-points in 2016-17. CONCLUSION This study developed and validated the first health-related criterion-referenced mCAFT cut-points for metabolic health among Canadian adults aged 18-69 years. These mCAFT cut-points may be useful in health surveillance, clinical, and public health settings. Novelty bullets • We developed and validated new criterion-referenced cut-points for the modified Canadian Aerobic Fitness Test to help identify adults at potential risk of poor metabolic health. • These new cut-points could help support national health surveillance efforts.
Deletion of BAF250a affects oocyte epigenetic modifications and embryonic development

BRG1‐associated factor 250a (BAF250a) is a component of the SWI/SNF adenosine triphosphate‐dependent chromatin remodeling complex, which has been shown to control chromatin structure and transcription. BAF250a was reported to be a key component of the gene regulatory machinery in embryonic stem cells controlling self‐renewal, differentiation, and cell lineage decisions. Here we constructed Baf250aF/F;Gdf9‐cre (Baf250aCKO) mice to specifically delete BAF250a in oocytes to investigate the role of maternal BAF250a in female germ cells and embryo development. Our results showed that BAF250a deletion did not affect folliculogenesis, ovulation, and fertilization, but it caused late embryonic death. RNA sequencing analysis showed that the expression of genes involved in cell proliferation and differentiation, tissue morphogenesis, histone modification, and nucleosome remodeling were perturbed in Baf250aCKO MII oocytes. We showed that covalent histone modifications such as H3K27me3 and H3K27ac were also significantly affected in oocytes, which may reduce oocyte quality and lead to birth defects. In addition, the DNA methylation level of Igf2r, Snrpn, and Peg3 differentially methylated regions was decreased in Baf250aCKO oocytes. Quantitative real‐time polymerase chain reaction analysis showed that the relative messenger RNA (mRNA) expression levels of Igf2r and Snrpn were significantly increased. The mRNA expression level of Dnmt1, Dnmt3a, Dnmt3l, and Uhrf1 was decreased, and the protein expression in these genes was also reduced, which might be the cause for impaired imprinting establishment. In conclusion, our results demonstrate that BAF250a plays an important role in oocyte transcription regulation, epigenetic modifications, and embryo development.