Miracle-dz/UniFAR-FTUs huggingface dataset:
translatomic profiling of Drosophila oenocytes under aging and oxidative stress 1

32 Background: Aging is accompanied with loss of tissue homeostasis and accumulation of 33 cellular damages. As one of the important metabolic centers, aged liver shows altered lipid 34 metabolism, impaired detoxification pathway, increased inflammation and oxidative stress 35 response. However, the mechanisms for these age-related changes still remain unclear. In fruit 36 flies, Drosophila melanogaster, liver-like functions are controlled by two distinct tissues, fat 37 body and oenocytes. Although the role of fat body in aging regulation has been well studied, 38 little is known about how oenocytes age and what are their roles in aging regulation. To address 39 these questions, we used cell-type-specific ribosome profiling (RiboTag) to study the impacts of 40 aging and oxidative stress on oenocyte translatome in Drosophila. 41 Results: We show that aging and oxidant paraquat significantly increased the levels of reactive 42 oxygen species (ROS) in adult oenocytes of Drosophila, and aged oenocytes exhibited reduced 43 sensitivity to paraquat treatment. Through RiboTag sequencing, we identified 3324 and 949 44 differentially expressed genes in oenocytes under aging and paraquat treatment, respectively. 45 Aging and paraquat exhibit both shared and distinct regulations on oenocyte translatome. Among 46 all age-regulated genes, mitochondrial, proteasome, peroxisome, fatty acid metabolism, and 47 cytochrome P450 pathways were down-regulated, whereas DNA replication and glutathione 48 metabolic pathways were up-regulated. Interestingly, most of the peroxisomal genes were down49 regulated in aged oenocytes, including peroxisomal biogenesis factors and beta-oxidation genes. 50 Further analysis of the oenocyte translatome showed that oenocytes highly expressed genes 51 involving in liver-like processes (e.g., ketogenesis). Many age-related transcriptional changes in 52 oenocytes are similar to aging liver, including up-regulation of Ras/MAPK signaling pathway 53 and down-regulation of peroxisome and fatty acid metabolism. 54 Conclusions: Our oenocyte-specific translatome analysis identified many genes and pathways 55 that are shared between Drosophila oenocytes and mammalian liver, highlighting the molecular 56 and functional similarities between the two tissues. Many of these genes are altered in both aged 57 oenocytes and aged liver, suggesting a conserved molecular mechanism underlying oenocyte and 58 liver aging. Thus, our translatome analysis will contribute significantly to the understanding of 59 oenocyte biology, and its role in lipid metabolism, stress response and aging regulation. 60
RareEventsof Intragenusand IntraspeciesHorizontalTransfer of the 16S rRNA Gene

Horizontal gene transfer (HGT) of operational genes has been widely reported in prokaryotic organisms. However, informational genes such as those involved in transcription and translation processes are very difficult to be horizontally transferred, as described by Woese’s complexity hypothesis. Here, we analyzed all of the completed prokaryotic genome sequences (2,143 genomes) in the NCBI (National Center forBiotechnology Information)database, scanned forgenomeswithhigh intragenomicheterogeneityof16S rRNAgenecopies, andexploredpotentialHGTeventsof ribosomalRNAgenesbasedonthephylogeny,genomicorganization,andsecondary structuresof the ribosomal RNA genes. Our results revealed 28 genomes with relatively high intragenomic heterogeneity of multiple 16S rRNA gene copies (lowest pairwise identity<98.0%), and further analysis revealed HGT events and potential donors of the heterogeneous copies (suchasHGTfromChlamydiasuis toChlamydia trachomatis) andmutationeventsof someheterogeneouscopies (suchasStreptococcus suis JS14). Interestingly, HGT of the 16S rRNA gene only occurred at intragenus or intraspecies levels, which is quite different from the HGT of operational genes. Our results improve our understanding regarding the exchange of informational genes.
SYNTHETIC FIBROUS FLUORAMPHIBOLES AND THEIR PROPERTIES

Asbestiform fluoramphiboles with isomorphic substitutions of cations both in A, M(4) and M(l-3) positions have been synthesized by heating the fluorsilicate mlxtures at 90G1100'C under atmospheric pressure. Chemical, opticai and X-ray data showed that monoclinic syntlretic fluoramphiboles in which Mgz+ is partly substituted by Ni*, Coz+, Znz+, Cd2+ and Fe* can be referred to the richterite series. Isomorphous substitution Fe 3+ for Mg2+ gives the Mg-fluorarfvedsonite, but substitution Cr# for Mg'z+ gives intermediate member of the richterite-arfvedsonite fluoramphibole. There is a distinct tendency for increasing refractive indexes with increasing electronegativity of the substitute atom. The analysis of unit cell dimensions showed that the M(4) and M(2) are most probable structure positions for cation substitution of the fluorrichterite series under study. Some of the physical and chemical properties of the fluoramphiboles were'measured. The temperature ranges of the fluoramphibole decomposition are established to be 100-150' higher than those of the hydroxyamphiboles of the analogous compositions. Synthetic fibrous fluoramphiboles are nonhygroscopic and are stabie in acid and alkali media.
Gait Recognition via Disentangled Representation Learning

Gait, the walking pattern of individuals, is one of the most important biometrics modalities. Most of the existing gait recognition methods take silhouettes or articulated body models as the gait features. These methods suffer from degraded recognition performance when handling confounding variables, such as clothing, carrying and view angle. To remedy this issue, we propose a novel AutoEncoder framework to explicitly disentangle pose and appearance features from RGB imagery and the LSTM-based integration of pose features over time produces the gait feature. In addition, we collect a Frontal-View Gait (FVG) dataset to focus on gait recognition from frontal-view walking, which is a challenging problem since it contains minimal gait cues compared to other views. FVG also includes other important variations,e.g., walking speed, carrying, and clothing. With extensive experiments on CASIA-B, USF and FVG datasets, our method demonstrates superior performance to the-state-of-the-arts quantitatively, the ability of feature disentanglement qualitatively, and promising computational efficiency.
Title Compact frequency reconfigurable slot antenna with continuoustuning range for cognitive radios

The design of a compact frequency-reconfigurable slot antenna for cognitive radios is proposed in this paper. The antenna consists of a rectangular-ring slot, a T-shaped feed line, an inverted T-shaped stub and two varactors. The length of the rectangular-ring slot is designed to resonate at about 2.4 GHz. The inverted T-shaped stub is used to extend the current path, making the total size of the antenna smaller for low frequency operation. The two varactors are used to achieve continuous tuning. The proposed antenna is studied and designed using computer simulation. The simulated return loss, radiation pattern, realized peak gain and efficiency of the antenna are presented. Results show that the antenna has a wide tuning range from 2.14 to 3.33 GHz (43.51%) and is a potential candidate for use in cognitive radios.
Cleanliness and Vacuum Acceptance Tests for the UHV Cavity String of the XFEL Linac

The main linac of the European XFEL will consist of 100 accelerator modules, i.e. 800 superconducting accelerator cavities operated at a design gradient of 23.6 MV/m. In this context CEA-Saclay built an assembly facility designed to produce one module per week, ready to be tested at DESY. The facility overcame the foreseen production rate to one cryomodule each 4 days. We would like to highlight and discuss the critical fields: cleanliness and vacuum. A new assembly method to protect final assembly against particulates contamination has been implemented on the production line. Modules RF tests results are compared. Particle transport measurements on components used for the European XFEL accelerator module are presented. The results indicate that the nominal operation of the automated pumping and venting units will not lead to particle transport. Vacuum acceptance tests are of major interest: leak tests and residual gas analysis (RGA) is used to control the absence of contamination and air leak. The RGA specifications have been slightly relaxed.
Precision Optical Antenna Alignment System for Tracking Antennas in 6-DOF

We present on an all-optical spatial metrology system, the PiCMM, that aids in the alignment and tracking of antennas with accuracies on the order of 25 microns and 0.01 deg. This system speeds up millimeter-wave antenna alignment, does not require contact, and links spatial measurements to a laser tracker world coordinate frame. An automated Pixel Probe and dark-field imaging are used to directly measure the aperture geometry and its pose. These measurements are absolute in the world-frame of a laser tracker and associated coordinate metrology space of the antenna scanner. Thus, aperture geometries can be linked directly to any laser tracker target (i.e. 6DOF, 3DOF) and data such as that used to calibrate positioner kinematics. For example, the links and joints defining the Denavit-Hartenberg kinematic model of a robotic arm scanner. The new automated aspect of the system reduces alignment time to under an hour. The synergy with laser tracker targets allows for a high level of repeatability. Furthermore, antennas can be exchanged or realigned in the antenna scanner autonomously because antenna geometry and kinematic models reside in the same laser tracker coordinate metrology space.
Learning proposals for sequential importance samplers using reinforced variational inference

The problem of inferring unobserved values in a partially observed trajectory from a stochastic process can be considered as a structured prediction problem. Traditionally inference is conducted using heuristic-based Monte Carlo methods. This work considers learning heuristics by leveraging a connection between policy optimization reinforcement learning and approximate inference. In particular, we learn proposal distributions used in importance samplers by casting it as a variational inference problem. We then rewrite the variational lower bound as a policy optimization problem similar to Weber et al. (2015) allowing us to transfer techniques from reinforcement learning. We apply this technique to a simple stochastic process as a proof-of-concept and show that while it is viable, it will require more engineering effort to scale inference for rare observations 1 .
SE2TeC: A Scalable Engine for Efficient and Expressive Time Series Classification

Time Series (TS) data are ubiquitous in enormous application fields, such as medicine, multimedia, and finance. In this paper, we present SE4TeC: A Scalable Engine for efficient and expressive Time Series Classification, which brings novel optimizations to the state-of-the-art shapelet-based algorithm: (i) More efficient feature extraction; (ii) Better interpretability of both feature extraction and classification process; (iii) Scalability in the context of Big Data. SE2TeC’s effectiveness and efficiency are experimentally demonstrated over real-life datasets.
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In this paper, we show the relation between state space approach and transfer function approach for functional observer and state feedback design. Two approaches can be transformed into each other, based on this result. More importantly, we find that th= scate space approach introduces some severe, unnecessary restrictions in solving the problem. The restrictions are, however, reduced to be a trivial condition in transfer function approach. It is believed that the result presented in this paper will be useful in developing both approaches, and motivate some new results for solving the problem.
There exist no gaps between Gevrey differentiable and nowhere Gevrey differentiable

We verify that there exist no gaps between Gevrey differentiable and nowhere Gevrey differentiable in the sense that for given s > 1, there is a nowhere Gevrey differentiable function on R of order s that is Gevrey differentiable of order r for any r > s, which also gives a strong example that is Gevrey differentiable but nowhere analytic.
Regulation of Nuclear Factor k B Transactivation IMPLICATION OF PHOSPHATIDYLINOSITOL 3-KINASE AND PROTEIN KINASE C z IN c-Rel ACTIVATION BY TUMOR NECROSIS FACTOR a *

Transactivation by c-Rel (nuclear factor k B) was dependent on phosphorylation of several serines in the transactivation domain, indicating that it is a phospho-rylation-dependent Ser-rich domain. By Ser 3 Ala mu- tational and deletion analysis, we have identified two regions in this domain: 1) a C-terminal region (amino acids 540–588), which is required for basal activity; and 2) the 422–540 region, which responds to external stimuli as tumor necrosis factor (TNF) a or phorbol myristate acetate plus ionomycin. Ser from 454 to 473 were shown to be required for TNF a -induced activation, whereas Ser between 492 and 519 were required for phorbol myristate acetate plus ionomycin activation. Phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) z were identified as downstream signaling mol-ecules of TNF a -activation of c-Rel transactivating activity. Interestingly, dominant negative forms of PI3K inhibited PKC z activation and dominant negative PKC z inhibited PI3K-mediated activation of c-Rel transactivating activity, indicating a cross-talk between both enzymes. We have identified the critical role of different Ser for PKC z - and PI3K-mediated responses. Interest-ingly, those c-Rel mutants not only did not respond to TNF a but also acted as
Energy-selective neutron imaging for three-dimensional non-destructive probing of crystalline structures

Common neutron imaging uses the full polychromatic neutron beam spectrum to reveal the material distribution in a non-destructive way. Performing it with a reduced energy band, i.e. energy-selective neutron imaging, allows access to local variation in sample crystallographic properties. Two sample categories can be discerned with different energy responses. Polycrystalline materials have an energy-dependent cross-section featuring Bragg edges. Energy-selective neutron imaging can be used to distinguish between crystallographic phases, increase material sensitivity or penetration, improve quantification etc. An example of the latter is shown by the examination of copper discs prior to machining them into linear accelerator cavity structures. The cross-section of single crystals features distinct Bragg peaks. Based on their pattern, one can determine the orientation of the crystal, as in a Laue pattern, but with the tremendous advantage that the operation can be performed for each pixel, yielding crystal orientation maps at high spatial resolution. A wholly different method to investigate such samples is also introduced: neutron diffraction imaging. It is based on projections formed by neutrons diffracted from the crystal lattice out of the direct beam. The position of these projections on the detector gives information on the crystal orientation. The projection itself can be used to reconstruct the crystal shape. A three-dimensional mapping of local Bragg reflectivity or a grain orientation mapping can thus be obtained. c © 2015 The Authors. Published by Elsevier B.V. Selection and peer-review under responsibility of Paul Scherrer Institut.
Forecasting equilibrium quantity and price on the world natural rubber market

The purpose of this study was to determine the relationship between distributed leadership, a quality academic process, and institutional effectiveness as well as the mediating role f t quality academic process on th relationship between distributed leadership and institutional effectiveness in public u iversities in Nigeria. The study built on the research conducted by Calvo-Moral, Leal and Roldan in 2006 on a quality educational process based on a European quality management model. A survey of 346 lecturers from public universities in Nigeria was used to validate this model. The data collected were analyzed using the Smartpls software. The results confirmed that the three main constructs for this study were second order. It was also evident that there was a positive significant rel tionship between distributed lead rshi , the quality cademic process and institution l effective ess. The findings also evealed that distributed leadership practices can enhance the effectiveness of public universities through a quality academic process. This study was limited to public universities in Nigeria and as such further research could be carried out to involve private universities. Based on the outcomes of this study, to enhance university effectiveness, university leaders should be proactive in undertaking measures that will bring about a quality aca emic process. © 2019 Kasetsart Universi y. Article Info
Development of a measuring system for a micro hole using an optical fiber probe

INTRODUCTION In recent years, there have been increasing demands to measure the accuracy of micro holes of fuel injector nozzles, chemical fiber nozzles, optical fiber ferrules, and so on. It is very difficult to measure precisely the shape of a micro hole with a large length/diameter (L/D) ratio [1-4]. This paper presents a micro hole measuring system using an optical fiber probe. We examine the optimization of design parameters of an optical system using ray tracing. In a trial measuring system, the measuring accuracy is examined in an experiment.
Complete Polarization Control for a Nanofiber Waveguide Using Directional Coupling

Optical nanofiber waveguides are widely used for near-field delivery and measurement of light. Despite their versatility and efficiency, nanofibers have a critical drawback - their inability to maintain light's polarization state on propagation. Here, we design a directional coupler consisting of two crossed nanofibers to probe the polarization state at the waist region. Directionality of coupling occurs due to asymmetric dipolar emission or spin-locking when the evanescent field pattern breaks the mirror symmetry of the crossed-nanofiber system. We demonstrate that, by monitoring the outputs from the directional coupler, two non-orthogonal polarization states can be prepared at the nanofiber waist with a fidelity higher than 99%. Based on these states, we devise a simple and reliable method for complete control of the polarization along a nanofiber waveguide.
Estrogen Receptor Expression Activates the Transcriptional and Growth-inhibitory Response to Retinoids without Enhanced Retinoic Acid Receptor a Expression1

Estrogen receptor (KR)-positive human breast cancer cells are hormon-ally regulated and are inhibited by retinoids, whereas most ER-negative breast cancer cells arc not. Here, we compared retinoid-induced tran- scriptional activation and growth inhibition in the ER-negative breast cancer cell line \1DA-MB-231, stably transfected to express wild-type ER (S3Ãœ),with that of the ER-positive MCE-7 line and the ER-negative parental line. Retinoids inhibited growth of the ER-expressing S30 clone but not of the parental MDA-MB-231 cells. Unlike a previously reported MDA-MB-231 subclone that was transfected to express a mutated ER (G40ÃœV),S30 did not express increased levels of retinoid receptor RNA or protein, nor was there increased binding activity to retinoid-responsive DNA elements. However, stable expression of ER increased retinoid acti vation of transcription of a retinole acid (RA) response elements from the low level in MDA-MB-231 to approach the level of MCF-7. The restored growth inhibition and transcriptional regulation by RA were unaffected by treatment with ER agonists or antagonists. Transient expression of ER but not of other nuclear receptors in MDA-MB-231 cells also activated retinoid-induced transcription, showing that this response is specific to ER. Furthermore, the effect of exogenously expressed ER on retinoid response was much greater than that obtained by overexpression of RA receptor a and/or retinoid X receptor a. Finally, a panel of ER mutants showed that enhancement of retinoid-induced transcriptional activity was dependent on the integrity of the DNA binding domain.
Formulation and evaluation of lamivudine enclosed alginate microbeads

The objective of the present study was to prepare and evaluate microbeads for the controlled release of lamivudine from the prepared microbeads using different polymers. The microbeads were prepared by ionic gelation method. The prepared microbeads were characterized for FTIR, scanning electron microscopy (SEM), the percentage drug content, entrapment efficiency, and in vitro dissolution studies. Accelerated stability studies were also carried out for the formulations. The microbeads were spherical in shape and free flowing. The entrapment efficiency was varying from 76 to 86%. The release of drug from the microbeads was extended up to 8 to 12 hours. FTIR studies showed the stable character of lamivudine in the microbeads. SEM studies revealed that the microbeads were porous in nature. The release kinetics studies revealed that the prepared microbeads were best fitted to the zero order for all eight formulations and peppa’s model. The release kinetics data and characterization studies indicated that the drug release from microbeads was diffusion – controlled and the microbeads were stable in nature.
Millennial-scale variability in the productivity signal from the Alboran Sea record 48,000-28,000 years ago

Primary productivity of the Alboran Sea (Western Mediterranean) is reconstructed for the time interval 48,000 to 28,000 years BP using the following geochemical proxies: calcium carbonate, barium excess (Baexcess), total organic carbon (TOC) and alkenone concentration. The records show a consistent pattern that indicates enhanced productivity during Dansgaard/Oeschger (D/O) warm periods. At the same time, deep-water conditions were favorable for organic matter preservation in the sediments, as indicated by the variation in redox-sensitive elements, such as Mn, Cr or V, and by the δC record of benthic foraminifers. The Alboran Sea productivity variation during D/O cycles is explained by the succession of two climatic scenarios that led to latitudinal shifts of the westerly wind system. This mechanism would also account for the variability in the deep-water ventilation of the Western Mediterranean Sea.
Aero-Structural Blade Design of a High-Power Wind Turbine

The present work focused on the development of an aero-structural design framework for a high-power horizontal axis wind turbine. To achieve this, it was necessary to carefully characterize the blade, to develop a suitable fluid-structure interaction solver and, finally, to combine both with post-processing tools. A fluid-structure interaction solver was developed for OpenFOAM, dedicated to simulate wind turbine rotors. The fluid-structure coupling was achieved through a loose coupling strategy, which means that there are separated solvers for the flow and structure analysis, which are combined through the update of boundary conditions. To simulate the blades rotation movement, an approach based on the single rotating frame method was used, meaning that the whole domain rotated with the turbine rotor with a constant angular velocity. The simulations of the rotor produced valid and interesting results namely, correct flow fields and pressure distributions. Considering that it is expected horizontal axis wind turbine rotors to continue growing to even larger sizes than the one modeled, it was shown that blade displacements due to flow induced forces are definitely a problem that needs to be taken into account when designing new wind turbine blades.