Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterisation of Novel Resistive Switching Memory Devices

Resistive random access memory (RRAM) is widely considered as a disruptive technology that will revolutionize not only non-volatile data storage, but also potentially digital logic and neuromorphic computing. The resistive switching mechanism is generally conceived as the rupture/restoration of defect-formed conductive filament (CF) or defect profile modulation, for filamentary and non-filamentary devices respectively. However, details of the underlying microscopic behaviour of the resistive switching in RRAM are still largely missing. In this thesis, a defect probing technique based on the random telegraph noise (RTN) is developed for both filamentary and non-filamentary devices, which can reveal the resistive switching mechanism at defect level and can also be used to analyse the device performance issues. HfO2 is one of the most matured metal-oxide materials in semiconductor industry and HfO2 RRAM shows promising potential in practical application. An RTN-based defect extraction technique is developed for the HfO2 devices to detect individual defect movement and provide statistical information of CF modification during normal operations. A critical filament region (CFR) is observed and further verified by defect movement tracking. Both defect movements and CFR modification are correlated with operation conditions, endurance failure and recovery. Non-filamentary devices have areal switching characteristics, and are promising in overcoming the drawbacks of filamentary devices that mainly come from the stochastic nature of the CF. a-VMCO is an outstanding non-filamentary device with a set of unique characteristics, but its resistive switching mechanism has not been clearly understood yet. By utilizing the RTN-based defect profiling technique, defect profile modulation in the switching layer is identified and correlated with digital and analogue switching behaviours, for the first time. State instability is analysed and a stable resistance window of 10 for >106 cycles is restored through combining optimizations of device structure and operation conditions, paving the way for its practical application. TaOx-based RRAM has shown fast switching in the sub-nanosecond regime, good CMOS compatibility and record endurance of more than 1012 cycles. Several inconsistent models have been proposed for the Ta2O5/TaOx bilayered structure, and it is difficult to quantify and optimize the performance, largely due to the lack of microscopic description of resistive switching based on experimental results. An indepth analysis of the TiN/Ta2O5/TaOx/TiN structured RRAM is carried out with the RTN-based defect probing technique, for both bipolar and unipolar switching modes. Significant differences in defect profile have been observed and explanations have been provided.
No . 7203 Category 1 : Public Finance Insecure Property Rights and the Missing Middle

We analyze a theoretical model in which entrepreneurs’ property rights are threatened by “raiders” who can challenge them to a contest for control of their firms. Entrepreneurs have heterogeneous productivity, and decide how much capital to invest before raiders decide whom to attack. In equilibrium, low productivity entrepreneurs are unaffected by the existence of raiders, while midand high-productivity entrepreneurs suffer. However, while raiders essentially act like a tax for the highest productivity entrepreneurs, the investment behavior of mid-productivity entrepreneurs who try to avoid an attack is more drastically affected. Our model provides a novel theoretical explanation for the “missing middle” observed in many countries with insecure property rights.
Design of cross-coupled CMAC for contour-following – a reinforcement-based ILC approach

ABSTRACT One of the most popular applications of a bi-axial motion stage is precision motion control. The reduction of tracking error and contour error is one of the most coveted goals in precision motion control systems. The accuracy of a motion control system is often affected by external disturbances. In addition, system non-linearity such as friction also represents a major hurdle to motion precision. In order to deal with the aforementioned problem, this paper proposes a fuzzy logic-based Reinforcement Iterative Learning Control (RILC) and a Cross-Coupled Cerebellar Model Articulation Controller (CCCMAC). In particular, the proposed fuzzy logic-based RILC and a LuGre friction model-based compensation approach are exploited to improve motion accuracy. The fuzzy logic-based RILC aims at reducing tracking error and compensating for external disturbance, while the LuGre friction model is responsible for friction compensation. In addition, the CCCMAC consisting of a cerebellar model articulation controller and a cross-coupled controller aims at reducing contour error and dealing with the problem of dynamics mismatch between different axes. Performance comparisons between the proposed fuzzy logic-based Reinforcement Iterative Learning Cross-Coupled Cerebellar Model Articulation Controller (RIL–CCCMAC) and several existing control schemes are conducted on a bi-axial motion stage. Experimental results verify the effectiveness of the proposed RIL–CCCMAC.
This is a repository copy of Valuing health-related quality of life in heart failure: a systematic review of methods to derive quality-adjusted life years (QALYs) in trial-based

The accurate measurement of health-related quality of life (HRQoL) and the value of improving it for patients are essential for deriving quality-adjusted life years (QALYs) to inform treatment choice and resource allocation. The objective of this reviewwas to identify and describe the approaches used to measure and value change in HRQoL in trial-based economic evaluations of heart failure interventions which derive QALYs as an outcome. Three databases (PubMed, CINAHL, Cochrane) were systematically searched. Twenty studies reporting economic evaluations based on 18 individual trials were identified. Most studies (n = 17) utilised generic preference-based measures to describe HRQoL and derive QALYs, commonly the EQ-5D-3L. Of these, three studies (from the same trial) also used mapping from a condition-specific to a generic measure. The remaining three studies used patients’ direct valuation of their own health or physician-reported outcomes to derive QALYs. Only 7 of the 20 studies reported significant incremental QALY gains.Most interventions were reported as being likely to be cost-effective at specified willingness to pay thresholds. The substantial variation in the approach applied to derive QALYs in the measurement of and value attributed to HRQoL in heart failure requires further investigation.
University of Birmingham Adaptive thermostats for noisy gradient systems

We study numerical methods for sampling probability measures in high dimension where the underlying model is only approximately identiﬁed with a gradient system. Extended stochastic dynamical methods are discussed which have application to multiscale models, nonequilibrium molecular dynamics and Bayesian sampling techniques arising in emerging machine learning applications. In addition to providing a more comprehensive discussion of the foundations of these methods, we propose a new numerical method for the Adaptive Langevin/Stochastic Gradient Nos´e-Hoover Thermostat that achieves a dramatic improvement in numerical eﬃciency over the most popular stochastic gradient methods reported in the literature. We also demonstrate that the newly-established method inherits a superconvergence property (fourth order convergence to the invariant measure for conﬁgurational quantities) recently demonstrated in the setting of Langevin dynamics. Our ﬁndings are veriﬁed by numerical experiments.
Power Outage Detection Methods for the Operation of a Shunt Active Power Filter as Energy Backup System

This paper presents the study of power outage detection methods that can be applied to a Shunt Active Power Filter (SAPF) with energy backup capability. SAPFs can successfully compensate Power Quality problems related with distorted or unbalanced currents and low power factor. Future Smart Grids will combine devices, control strategies and functionalities to increase the grid reliability and the power management capability. One of the main tools necessary to enable these features is the information of what is occurring in all the smart grid parts. In this context the fast detection of power outages is critical, so this paper also contributes for the discussion of the best ways to extract information in the context of future smart grids. The combination of information and flexible devices in a smart grid will enable the implementation of collective awareness systems, which can deal with different electrical grid problems and situations in an organic manner.
Hepatocyte-Stimulating Factor , I 2 Interferon , and Interleukin-1 Enhance Expression of the Rat a ,-Acid Glycoprotein Gene via a Distal Upstream Regulatory Region

The rat al-acid glycoprotein (AGP) gene is transcriptionally regulated by dexamethasone, interleukin 1 (IL-1), hepatocyte-stimulating factor, and j2 interferon. The steroid and peptide hormones stimulate expression of the AGP gene synergistically as well as independently. The regulatory sequence responsible for dexamethasone-stimulated expression has been localized previously to a region that is 120 to 64 base pairs (bp) upstream of the transcription start site (H. Baumann and L. E. Maquat, Mol. Cell. Biol. 6:2551-2561, 1986). To identify the regulatory sequence that is responsive to the peptide hormones, different lengths of the AGP gene 5'-flanking DNA were linked to the chloramphenicol acetyltransferase gene and then assayed for hormone-inducible chloramphenicol acetyltransferase gene expression in transiently transfected HepG2 cells. We demonstrate that an enhancer region that is responsive to IL-1, hepatocyte-stimulating factor, and (2 interferon lies within a 142-bp sequence located 5,300 to 5,150 bp upstream of the transcription start site. This distal regulatory region can confer hormone inducibility to a heterologous promoter; exert its affect in either orientation; and function, to a lesser degree, in nonhepatic but IL-1-responsive cells.
The Green River natural analogue as a field laboratory to study the long-term fate of CO2 in the subsurface

Understanding the long-term response of CO2 injected into porous reservoirs is one of the most important aspects to demonstrate safe and permanent storage. In order to provide quantitative constraints on the long-term impacts of CO2-charged fluids on the integrity of reservoir-caprock systems we recovered some 300m of core from a scientific drill hole through a natural CO2 reservoir, near Green River, Utah. We obtained geomechanical, mineralogical, geochemical, petrophysical and mineralogical laboratory data along the entire length of the core and from non CO2-charged control samples. Furthermore, we performed more detailed studies through portions of low permeability layers in direct contact with CO2-charged layers. This was done to constrain the nature and penetration depths of CO2-promoted fluid-mineral reaction fronts. The major reactions identified include the dissolution of diagenetic dolomite cements and hematite grain coatings, and the precipitation of ankerite and pyrite and have been used as input for geochemical 1D reactive transport modelling, to constrain the magnitude and velocity of the mineral-fluid reaction front. In addition, we compared geomechanical data from the CO2-exposed core and related unreacted control samples to assess the mechanical stability of reservoir and seal rocks in a CO2 storage complex following mineral dissolution and precipitation for thousands of years. The obtained mechanical parameters were coupled to mineralogy and porosity. Key aim of this work was to * Corresponding author. Tel. : +31(0)70-447-5899 E-mail address: andreas.busch@shell.com 2822 A. Busch et al. / Energy Procedia 63 ( 2014 ) 2821 – 2830 better quantify the effect of long-term chemical CO2/brine/rock interactions on the mechanical strength and elastic properties of the studied formations. © 2013 The Authors. Published by Elsevier Ltd. Selection and peer-review under responsibility of GHGT.
DDDT_A_265423 3495..3507

1Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, People’s Republic of China; 2Department of Pharmacology, School of Basic Medicine, Capital Medical University, Beijing 100069, People’s Republic of China; 3Central Nervous System Drug Key Laboratory of Sichuan Province, Luzhou, Sichuan 646000, People’s Republic of China Purpose: MiR-34a, which acts as an important tumor suppressor gene, plays an important role in pancreatic cancer. However, the therapeutic application of miR-34a is limited by the lack of an effective delivery system. In the present study, we synthesize exosomes-coated miR-34a (exomiR-34a), and the anticancer effect of exomiR-34a was evaluated in pancreatic cancer. Materials and Methods: An ultrasound approach was used to synthesize exomiR-34a, and its transfection efficiency was examined by confocal microscopy and flow cytometry. The level of miR-34a and its targeted gene Bcl-2 was detected by real-time quantitative PCR (qRT-PCR). MTT analysis was performed to determine the effect of exomiR-34a on the growth of pancreatic cancer cells. Annexin-V/PI double staining and Western blot analysis were carried out to determine the apoptosis of the pancreatic cancer cells. The xenograft nude mice model bearing human pancreatic cancer Panc28 cells was used to determine the antitumor effect of exomiR-34a in vivo. Results: The exomiR-34a could cross the cell membrane efficiently, and downregulated the expression of the targeted gene Bcl-2. Treatment with exomiR-34a inhibited the growth of the pancreatic cancer cells significantly and the nanoparticles also induced apoptosis in cancer cells via affecting the expression of apoptotic-related genes. In vivo study using xenograft nude mice bearing Panc28 cancer cells revealed that exomiR-34a suppressed the growth of tumors significantly. Conclusion: ExomiR-34a can inhibit the growth of pancreatic cancer both in vitro and in vivo. Targeting miR-34a is a promising strategy for the treatment of pancreatic cancer. ExomiR-34a has the potential to be developed as a novel anticancer agent for the treatment of human pancreatic malignancy.
Effect of Intellectual Capital on the Profitability of Nigerian Deposit Money Banks

This study assessed the effect of intellectual capital on the profitability of Nigerian deposit money banks. The specific objectives are: To ascertain the effect of Structural Capital Efficiency (SCE) on the profitability of Nigerian deposit money banks; to determine the effect of Human Capital Efficiency Coefficient (HCE) on the profitability of Nigerian deposit money banks and to examine the effect of Capital Employed Efficiency Coefficient (CEE) on the profitability in Nigerian deposit money banks. The study adopted Ex postFacto research design. The study used sample of fifteen (15) Nigerian deposit money banks quoted on the Nigerian Stock Exchange from 2010 to 2018 The data for the study was collected from annual reports and accounts of the deposit money banks quoted on the Nigerian Stock Exchange. Regression analysis was employed to test the formulated hypotheses with the aid of eview version 9.0. The study revealed that Structural Capital Efficiency (SCE) has positive significant effect on the profitability of Nigerian deposit money banks. The study also revealed that Human Capital Efficiency Coefficient (HCE) has positive effect on the profitability of Nigerian deposit money banks, but is not statistically significant. In addition, Capital Employed Efficiency Coefficient (CEE) has positive effect on the profitability of Nigerian deposit money banks, but is not statistically significant. The study therefore recommended among others that Banks in Nigeria especially the Deposit Money Banks should adopt an intellectual capital strategy. This can be done by banks adding the position of Chief Intellectual Capital Management Officer (CICMO) on their organizational chart to help in structuring relevant strategies and policies on how to obtain and best utilize the required resources underlying IC.
OTT_A_237099 945..958

*These authors contributed equally to this work Purpose: The purpose of the present study was to investigate the biological and clinical significance of GATA binding protein 3 (GATA3) in bladder cancer patients. Patients and Methods: For the detection of the correlation between GATA3 expression and bladder cancer, we downloaded the mRNA expression data from the Cancer Genome Atlas (TCGA) database and conducted immunohistochemistry staining on formalin-fixed paraffin-embedded (FFPE) sample tissues. Then, bladder cancer cell lines were utilized to investigate the potential functions of GATA3 by cell apoptosis, proliferation and cycle assays. Results: The mRNA data from TCGA database and bladder cancer cell lines suggested that GATA3 mRNA expression was significantly higher compared with normal tissues and cells. Conversely, the Western blot assay revealed that the expression of GATA3 was significantly lower in bladder cancer than normal urothelial cell line. Additionally, we found that overexpression of GATA3 was significantly associated with tumor subtype (P = 0.001 in TCGA; P = 0.004 in FFPE tissues), earlier clinical stage (P < 0.001 in TCGA; P < 0.001 in FFPE) and lower grade tumor (P = 0.057 in TCGA; P = 0.002 in FFPE). Kaplan-Meier analysis and multivariate Cox regression analysis indicated that age (P < 0.001 in both cohort), clinical stage (P = 0.028 in TCGA; P = 0.011 in FFPE), recurrence (P < 0.001) and low GATA3 in TCGA cohort (P = 0.035) but high GATA3 in FFPE cohort (P = 0.033) were independent risk factors for overall survival in patients. The assay to detect potential functions of GATA3 indicated that this biomarker could arrest the cell cycle of G2/M and S phase in T24 cells, and inhibit bladder cancer cells proliferation. Conclusion: Collectively, our findings identified that GATA3 served as an important prognosis biomarker for bladder cancer patients. However, the mechanism of GATA3 in bladder cancer deserves further studies.
gene mutation in the teichoic acids alanylation system of results in diminished proliferation in its natural host

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. gene mutation in the teichoic acids alanylation system of results in diminished proliferation in its natural host. P. Reimundo, A. Menéndez, J. Méndez, D. Pérez-Pascual, R. Navais, E. Gómez, A.F. Braña, J.A. Guijarro
Development of Privacy-Preserving Online Monitoring Framework for Online healthcare Applications

— Privacy concern is one of the biggest obstacles in widespread adoption of online monitoring services on e-health applications, even though online monitoring can significantly improve the accuracy and quality of e-health applications. To prevent privacy loss during online monitoring, we have preliminarily proposed a privacy-preserving online monitoring framework (PPoM) that enables healthcare providers and patients to intuitively specify their own privacy policies and enforces patients’ privacy policies in systematic manner during monitoring. For practical use of the PPoM framework, in this paper, we present the prototype development of the PPoM framework in detail. For the better understanding, we provide example usages from the standpoints of both healthcare providers and patients. To prove the performance of the developed prototype, we present evaluation results.
FACTORS INFLUENCING FUNCTIONAL HEALTH STATUS OF STROKE PERSONS RECEIVING CONTINUITY OF CARE AT TUMBON HEALTH PROMOTING HOSPITALS (THPHs)

This descriptive model testing, cross-sectional study design, aimed to test the model depicting the pattern of relationships among structural variables (patients’ age and caregiver) and process variables (patients’ perception of quality of nursing care, patients’ perception of continuity of care, and patients’ perception of co-ordination of care) to influence the outcome variable (functional health status) of stroke persons receiving continuity of care at TumbonHealth Promoting Hospitals (THPHs). Nursing Role Effectiveness Model (NREM) was used as the conceptual framework of this study. Multi-stage random sampling was employed to obtain 200 stroke persons living in Chiangmai province. Data were collected by three questionnaires including 1) demographic information; 2) the modified of Chronic Care Competency Scale (CCCS); and 3) the Short Form-12 (SF-12 version 2) health survey. The AMOS software program was utilized to test the study model by using bootstrap method. The final model showed that functional health status influenced by patients’ age through patients’ perception of quality of nursing care and caregivers through patients’ perception of continuityof care, co-ordination of care, and quality of nursing care. The model explained 7% (R2=.07) of the variance for functional health status. The findings suggested that to improve functional health status of stroke persons, professional nurses who worked at THPHs should provide quality of stroke care concerning stroke’s age, their caregivers, and working as a collaborator and coordinating team with other health care providers.
AN APPROXIMATION THEOREM FOR HARDY FUNCTIONS ON C-LINEARLY CONVEX DOMAINS OF INFINITE TYPE IN C2

Let Ω ⊂ C be a smoothly bounded, C-linearly convex domain. We prove that if Ω is of F -type at all boundary points (for some type function F ), then for all 1 ≤ p < ∞, every Hardy function f ∈ H(Ω) is approximated by a sequence of holomorphic functions on Ω in the H-norm.
Gauss and Poisson approximation: applications to CDO tranches pricing

This article describes a new numerical method, based on Stein’s method and zero bias transformation, to compute CDO tranche prices. We propose first order correction terms for both Gauss and Poisson approximations and the approximation errors are discussed. We then combine the two approximations to price CDOs tranches in the conditionally independent framework using a realistic local correlation structure. Numerical tests show that the method provides robust results with a very low computational burden. Acknowledgement: this work is partially supported by La Fondation du Risque. We are also grateful to the referees for very valuable comments and suggestions.
CMAR_A_263559 7405..7417

1Department of Cardio-Thoracic Surgery, Central Hospital of Enshi Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi, Hubei, People’s Republic of China; 2Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China; 3Clinical Research Center, Wuhan Medical and Health Center for Women and Children, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 4Department of Rheumatism Immunology, Wuhan Medical and Health Center for Women and Children, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 5Department of Gastrointestinal Surgery, Central Hospital of Enshi Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi, Hubei, People’s Republic of China