Miracle-dz/UniFAR-FTUs huggingface dataset:
CLONING AND EXPRESSION ANALYSIS OF JcAACT , JcMDC AND JcFPS , INVOLVED IN TERPENOID BIOSYNTHESIS IN JATROPHA CURCAS L .

To better understand the functions of key genes involved in terpenoid biosynthesis in Jatropha curcas, we cloned and characterized three genes, namely acetyl CoA acyltransferase (JcAACT), diphosphate mevalonate decarboxylase (JcMDC) and farnesyl pyrophosphate synthase (JcFPS). The opening reading frames (ORFs) of JcAACT, JcMDC and JcFPS were 1239 bp,1248 bp and 1029 bp, respectively, encoding a 412-amino acid, 415-amino acid and 342-amino acid polypeptide, respectively. Results of homology analysis showed that JcAACT, JcMDC and JcFPS encoded proteins that all had the highest identity and closest relationship with the corresponding genes in Hevea brasiliensis, with identities of 89%, 92% and 93%, respectively. JcAACT, JcMDC and JcFPS were expressed in all organs tested of J. curcas; the highest expression level for each gene occurred in seeds. In the early growth stage of seeds, the expression level of each of these three genes increased with time, with JcAACT and JcMDC expression level reaching a peak at the late stage of seed development (50 d), while JcFPS expression level reached a peak at the mid-late stage (40 d). Following the peak, the expression of each gene then declined. The expression level of JcAACT was the highest of the three genes, regardless of the organ or the stage of seed growth, indicating its important role in J. curcas. This study lays the foundation for a better understanding of the important role of the JcAACT, JcMDC and JcFPS genesin the terpenoid biosynthesis pathway of J. curcas.
Process Mining with Semantics : Real-time Application on a Learning Process Domain

Automated means for extraction, analysing or harmonization of various kinds of data that are stored in today’s information systems is indispensable to perform an effective process mining (PM). In view of that, this paper introduces a semantic-based process mining approach that is capable of detecting useful patterns or trends within any given data or process base. The work illustrates the method using a case study of the learning process domain. Essentially, the paper takes into account the context of the individual learners activities within a learning knowledge-base in order to find the best possible ways to efficiently realize (meta-analysis) the individual properties or attributes the process instances share amongst themselves within the knowledge-base. The goal is to identify patterns that have an effect on users performance and then respond by making decisions based on individual properties (assertions) and the classification process. Thus, the method of this paper is grounded on the semantic modelling and process mining techniques. Practically, the method uses the semantics of the captured events logs about the learning process and discovered models to create new knowledge that is applied for enhancement of the existing information knowledge-base. Theoretically, the work focus on augmenting the information values of the resulting process models based on the individual attributes (object and data properties) that are well-defined within an ontology. On one hand, in order to ensure validity, the work looks at the extent to which the individual process elements and harmonization is met. Whereas, reliability refers to the level of consistency in providing a well-suited inference mechanism or knowledge-base management system that is useful towards drawing valuable and/or accurate conclusions as a result of the improved method of process analysis.
Cahiers de praxématique, 72 | 2019

This paper focuses on the use of anaphoric constructions by learners of English. The objective is to propose a comparative analysis of it, this and that proforms between native English speakers (NS) and Spanish speakers learning English as a foreign language. Our analysis relies on a multicorpus approach in which texts from two corpora underwent a multi-level tagging process including morophosyntactic and pragmatic annotation with situational vs contextual and given vs new information distinctions. A dataset containing 428 occurrences of it, this and that was automatically built with features from the annotation layers. We conducted three pairwise binomial logistic regression modelling analyses in order to identify factors in the selection of the three forms. Results show that some pragmatic features are significant factors in the way speakers select the forms. The fact that a proform refers to a new or inferred entity in the context plays a key role in its selection. Concerning learner-specific factors, the subject position of the proform this influences its selection. Cet article aborde la question des constructions anaphoriques chez les apprenants de l’anglais. L’objectif est de mener une analyse comparative des proformes it, this et that entre des locuteurs natifs de langue anglaise et des apprenants d’anglais de L1 espagnol. Notre analyse se fonde sur une étude mettant en jeu deux corpus étiquetés par application de plusieurs couches d’annotation. Le schéma d’annotation comprend un étiquetage morphosyntaxique et pragmatique en intégrant les distinctions exophore/endophore et information nouvelle ou connue. Un jeu de données de 428 occurrences des trois proformes est automatiquement constitué à partir de l’extraction des formes et de leurs traits figurant dans les différentes couches d’annotation. Trois analyses par régression logistique binomiale sont effectuées sur les trois paires de proformes afin d’identifier les facteurs de sélection des formes. Les résultats des analyses montrent que les traits d’ordre pragmatique jouent un rôle significatif. Le renvoi à une entité nouvelle ou inférée est un facteur déterminant de sélection. En outre, la position sujet de this proforme apparaît comme un facteur spécifique aux apprenants. A Multifactorial analysis of this, that and it proforms in anaphoric construc. Cahiers de praxématique, 72 | 2019 20
Fatal attraction: identifying mobile devices through electromagnetic emissions

Smartphones are increasingly augmented with sensors for a variety of purposes. In this paper, we show how magnetic field emissions can be used to fingerprint smartphones. Previous work on identification rely on specific characteristics that vary with the settings and components available on a device. This limits the number of devices on which one approach is effective. By contrast, all electronic devices emit a magnetic field which is accessible either through the API or measured through an external device. We conducted an in-the-wild study over four months and collected mobile sensor data from 175 devices. In our experiments we observed that the electromagnetic field measured by the magnetometer identifies devices with an accuracy of 98.9%. Furthermore, we show that even if the sensor was removed from the device or access to it was discontinued, identification would still be possible from a secondary device in close proximity to the target. Our findings suggest that the magnetic field emitted by smartphones is unique and fingerprinting devices based on this feature can be performed without the knowledge or cooperation of users.
NONLINEAR ACTUATOR MODEL FOR FLEXOELECTRIC MEMBRANES

Synthetic and biological fl exoelectric membranes are actuators that bend under the action of external electric fi elds, a phenomenon of interest to the development of emerging adaptive materials as well as biological mechano-transduction. This paper presents an actuator model of fl exoelectric membranes based on a Helmholtz free energy that incorporates tension, bending, and torsion as well as polarization and dielectric energies. The electro-elastic components of the membrane tension, moment tensor and tensor are derived and used to construct an actuator model that includes dissipation due to viscous fl uids in contact with the membrane. The actuator model is expressed by a balance between the externally imposed electric forces, the viscous dissipation of the contacting fl uid phases, and the elastic storage of the membrane. The nonlinearity is shown to originate in the viscous dissipation. The model is analyzed for externally imposed oscillating electric fi elds. The Deborah number De given by the ratio of driving frequency and the resonant frequency is shown to control the viscoelastic response. The key fi ndings are: (i) for De 1 the response is purely elastic and the electric energy is stored in the elastic deformations of the membrane; (ii) at larger De, the response is anharmonic and viscoelastic; (iii) due to the nature of the viscous nonlinearity only even harmonics are generated in the response; and (iv) secondary resonant frequencies appear at lower driving frequencies. These fi nding contribute towards the emerging understanding of fl exoeletricity in biological membranes, pioneered by Petrov and co-workers (Petrov, A.G., The Lyotropic State of Matter, Gordon and Breach Science Publishers: Amsterdam, 1999).
INVESTIGATION OF THE MEMBRANES PERMEABILITY OF THE FLOW CONTROL DEVICE BASED ON PIEZO ACTUATOR

Piezoelectric actuators are simple design, small size, and relatively low cost elements, suitable for precision positioning systems. Therefore, actuators of such type were chosen for the design of the flow control device. Flow control membrane of the device consists of two plates with micro pores or notches. One of the plates, depending on the type of the actuator, may carry out a rotary motion. While mowing, membrane plates with notches or formed micro pores create a Moiré pattern between them, which depends on the flow throughput parameters. Adjusting piezoelectric actuator’s position and the Moiré effect resulted between the membranes, it was created a quick, accurate, and relatively inexpensive flow control device. The created flow control device with piezoelectric actuators and Moiré geometric effect is used in gas, liquid, and light flow control systems, and is characterized by its throughput and precision. Such devices are simple and are suitable particularly for precise dosing of flows. The design of the flow control device is patented protected.
1 ESTABLISHING A PARTICIPATORY LIBRARY MODEL : A GROUNDED THEORY STUDY

Purpose: The purpose of this research is to explore the idea of the participatory library in higher education settings. This research aims to address the question, what is a participatory university library? Design/methodology/approach: Grounded theory approach was adopted. In-depth individual interviews were conducted with two diverse groups of participants including ten library staff members and six library users. Data collection and analysis were carried out simultaneously and complied with Straussian grounded theory principles and techniques. Findings: Three core categories representing the participatory library were found including “community”, “empowerment”, and “experience”. Each category was thoroughly delineated via sub-categories, properties, and dimensions that all together create a foundation for the participatory library. A participatory library model was also developed together with an explanation of model building blocks that provide a deeper understanding of the participatory library phenomenon. Research limitations: The research focuses on a specific library system, i.e., academic libraries. Therefore, the research results may not be very applicable to public, special, and school library contexts. Originality/value: This is the first empirical study developing a participatory library model. It provides librarians, library managers, researchers, library students, and the library community with a holistic picture of the contemporary library.
Differential Ca signaling by thrombin and protease-activated receptor-1-activating peptide in human brain microvascular endothelial cells

Kim, Yuri V. , Francescopaolo Di Cello, Coryse S. Hillaire, and Kwang Sik Kim. Differential Ca signaling by thrombin and protease-activated receptor-1-activating peptide in human brain microvascular endothelial cells. Am J Physiol Cell Physiol 286: C31–C42, 2004. First published August 27, 2003; 10.1152/ajpcell.00157. 2003. —Thrombin and related protease-activated receptors 1, 2, 3, and 4 (PAR1–4) play a multifunctional role in many types of cells including endothelial cells. Here, using RT-PCR and immunofluorescence staining, we showed for the first time that PAR1–4 are expressed on primary human brain microvascular endothelial cells (HBMEC). Digital fluorescence microscopy and fura 2 were used to monitor intracellular Ca concentration ([Ca ]i) changes in response to thrombin and PAR1-activating peptide (PAR1-AP) SFFLRN. Both thrombin and PAR1-AP induced a dose-dependent [Ca ]i rise that was inhibited by pretreatment of HBMEC with the phospholipase C inhibitor U-73122 and the sarco(endo)plasmic reticulum Ca -ATPase inhibitor thapsigargin. Thrombin induced transient [Ca ]i increase, whereas PAR1-AP exhibited sustained [Ca ]i rise. The PAR1-AP-induced sustained [Ca ]i rise was significantly reduced in the absence of extracellular calcium or in the presence of an inhibitor of store-operated calcium channels, SKF-96365. Restoration of extracellular Ca to the cells that were initially activated by PAR1-AP in the absence of extracellular Ca resulted in significant [Ca ]i rise; however, this effect was not observed after thrombin stimulation. Pretreatment of the cells with a low thrombin concentration (0.1 nM) prevented [Ca ]i rise in response to high thrombin concentration (10 nM), but pretreatment with PAR1-AP did not prevent subsequent [Ca ]i rise to high PAR1-AP concentration. Additionally, treatment with thrombin decreased transendothelial electrical resistance in HBMEC, whereas PAR1-AP was without significant effect. These findings suggest that, in contrast to thrombin, stimulation of PAR1 by untethered peptide SFFLRN results in stimulation of store-operated Ca influx without significantly affecting brain endothelial barrier functions.
Discriminating Between the Hakes Merluccius Hubbsi and M . Australis on the Basis of their Otolith Morphometrics

In the Southwest Atlantic south of 47°S, the distributions of Merluccius hubbsi and Merluccius australis partially overlapped. As adult fish of both hakes have a similar appearance, it is suspected that they are often misclassified, particularly by observers on board of commercial vessels. Since otoliths are considered to be potentially determinant features at the specific level, we utilized sagittae morphometry to distinguish between adults (50 to 70 cm) of either species. By considering properly identified specimens of M. hubbsi and M. australis captured during research surveys, some otolith size variables, as well as, shape indices and an outline analysis (Elliptic Fourier Analysis) were used to obtain a discriminant function. This function was then applied to other sets of otolith samples collected from the commercial fleet and presumed to include some misclassifications. Discriminant analysis including all variables (Model 1) correctly classified the surveys samples of M. australis and M. hubbsi with 100% accuracy, whereas Eliptic Fourier Analysis (Model 2) was more effective (91%) than size variables and shape indices (82%, Model 3). This work highlights the advantages of considering together shape indices and Fourier coefficients to achieve more accurate differentiation between species that show similar otoliths. The discriminant function (Model 1) applied to otoliths from commercial fishing suggested that a significant number of M. australis would have been misidentified as M. hubbsi (72% error). Circularity and mainly otolith weight also showed significant differences between species, the later appearing as a usefull, easier-to-record alternative to this purpose. On the other hand, neither the presence or absence of Excisura ostii on the ventral side of the otoliths, nor the border type (serrated or flat) were so powerfull, in spite of being a flat border (97%) and the presence of E. ostii (84%) more frequent in common hakes (M. hubbsi) than among southern hakes (48 and 52%, respectively).
Hybrid intravascular management of pediatric complex tubular aortic coarctation in the shadow of SARS-CoV-2 pandemic

Introduction. Coarctation of the aorta (CoA) is a congenital heart defect defined as a narrowing in the region of aortic isthmus, clinically presenting with peripheral perfusion disturbances in physical examination. Newborns are majority of the affected and surgery is the management of choice in these patients. However, some may not present with CoA symptoms until later childhood, with mostly percutaneous interventions as a favorable method of treatment. Aneurysms, heart failure and stroke are the main complications of untreated CoA, which explains low survival rate of undiagnosed patients. Case report. A 5-year-old female patient in good general condition presented with a heart murmur during a prophylactic pediatric control. The patient was referred to pediatric cardiologist, but unfortunately due to ongoing coronary disease 2019 pandemic only telemedical consultation was available, precluding physical examination. Finally, the patient was referred to hybrid pediatric cardiac surgery department as an urgent consultation of the dubious anamnesis. The echocardiographic study revealed continuous, non-pulsatile flow in the abdominal aorta with a narrowed descending aorta behind the left atrium, and the CoA was a suspected diagnosis. The angio-computed tomography (CT) confirmed tubular (55 mm long) narrowed section of thoracic aorta (up to 2.5 mm diameter) with concomitant collateral circulation. Due to the anatomy of the aortic lesion the patient was referred for transcatheter stent graft (Bentley BeGraft 9 mm/ /57 mm) implantation with ECC-backup. An initial dilatation to 9 mm except the region around 6mm long narrowed to 5.2 mm was performed. After 2 months, the stent graft was dilated again, and echocardiography confirmed uniformed aortic lumen (9 mm). The postprocedural course was uncomplicated; the patient was discharged home and referred for further follow-up. Conclusions. The CoA rarely occupies a non-typical region and therfore may be diagnostically challenging without a profound phisical examination, particularly in later childhood and pandemic settings, and may result in serious complications, if untreated.
Factors in Homo and Heterotypic Aggregate Formation in Sepsis

Sepsis, a severe systemic inflammatory response to an infection that can be bacterial, viral or fungal in origin, remains a serious condition with high mortality. The dynamics in the immune response (immune activation, over activation and exhaustion) during development and progression of sepsis pose a problem in the design of new treatment approaches. This review focuses on the understanding of molecular interactions that lead to the formation of cellular aggregates in sepsis and puts novel treatment targets in the context of these interactions.
Modeling of a DC-RF Plasmathruster with the Navier-Stokes Code SINA IEPC-2013-324

High power electric propulsion systems are currently under investigation with respect to planned and foreseen piloted exploration missions such as the human flight to Mars. For the further development and optimization of such electric thrusters numerical simulations can make a valuable contribution. The numerical models used for the simulations have to account for all important thermophysical aspects of the flow field within the thrusters. In order to simulate DC-RF plasma thrusters, not only the thermal and chemical nonequilibrium plasma flow has to be modeled, but also the DC and RF discharge. This paper describes the models that are implemented in the loosely coupled Navier-Stokes code SINA, which is being developed at the Institute of Space Systems (IRS). Preliminary results of a numerical simulation of the hybrid DC-RF thruster TIHTUS are presented and discussed.
Climate shocks, food price stability and international trade: evidence from 76 maize markets in 27 net-importing countries

Do food imports increase the variability of domestic food prices? The answer to this question depends onwhether foreign production ismore volatile than domestic production. If imports are likely to destabilize domestic prices, storing crops for future consumptionmay prove an appealing strategy to copewith the adverse supply effects of amore unstable climate. Unfortunately, public storage has proven to be unsustainable due to the high costs of carrying crop inventories over time and the inability of policy planners to correctly forecast changes in domestic supply. Therefore, understanding the roles of imports and stocks on domestic food price instability is important as domestic shortfalls in food production are likely to becomemore frequent as theworld’s climate becomeswarmer. Using maize prices observed in 76maizemarkets of 27maize net importers across Africa, Asia and Latin America during 2000–2015, we find that, on average, a 1% increase in the ratio of imports to total consumption is correlatedwith a 0.29% reduction of the intra-annual coefficient of variation ofmaize prices; likewise a 1% increase in the amount ofmaize available in stocks at the beginning of the season is correlated with a 0.22% reduction in the said coefficient.We alsofind that climate-induced supply shocks towardmid-centurymay increasemaize price variability in the focus countries by around 10%; these increases could be offset with similar increases in the ratio of imports to total consumption or in the stock-to-use ratio at the beginning of the cropmarketing year. The fact that both imports and stocks help to stabilize domestic prices suggests that their uses should hinge on a careful cost-benefit analysis, including the risk of facingworld productionmore variable than domestic production and the costs of carryingmaize inventories over time.