Miracle-dz/UniFAR-FTUs huggingface dataset:
Sulindac Sulfide Is a Noncompetitive γ-Secretase Inhibitor That Preferentially Reduces Aβ42 Generation*

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been known to reduce risk for Alzheimer's disease. In addition to the anti-inflammatory effects of NSAIDs to block cylooxygenase, it has been shown recently that a subset of NSAIDs selectively inhibits the secretion of highly amyloidogenic Aβ42 from cultured cells, although the molecular target(s) of NSAIDs in reducing the activity of γ-secretase for Aβ42 generation (γ42-secretase) still remain unknown. Here we show that sulindac sulfide (SSide) directly acts on γ-secretase and preferentially inhibits the γ42-secretase activity derived from the 3-[(3-cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate-solubilized membrane fractions of HeLa cells, in an in vitroγ-secretase assay using recombinant amyloid β precursor protein C100 as a substrate. SSide also inhibits activities for the generation of Aβ40 as well as for Notch intracellular domain at higher concentrations. Notably, SSide displayed linear noncompetitive inhibition profiles for γ42-secretase in vitro. Our data suggest that SSide is a direct inhibitor of γ-secretase that preferentially affects the γ42-secretase activity.
Geolocators on Raptors: Advantages and Limitations of a New Tracking Technology

GEOLOCALIZADORES EN AVES RAPACES: VENTAJAS Y LIMITACIONES DE UNA NUEVA TECNOLOGIA DE LOCALIZACION Recientemente, se ha ampliado el uso de geolocalizadores sensibles a la luz para rastrear los movimientos de las aves, incluyendo una serie de estudios en que son colocados tanto en rapaces diurnas como en nocturnas. Estos registradores de datos ligeros ofrecen un costo relativamente bajo por unidad, un largo tiempo de seguimiento (>2 anos) y se pueden utilizar en las especies que son muy pequenas para la telemetria por satelite. Los geolocalizadores tambien presentan algunas limitaciones importantes: deben ser recuperados de los individuos y las localidades resultantes se encuentran a una escala bastante cruda de resolucion, lo que limita su uso en aves migratorias de corta y media distancia. Ademas, algunos estudios han demostrado que un metodo de fijacion comunmente utilizado puede presentar serios riesgos para las aves. Al igual que con cualquier marcador auxiliar, los investigadores que consideren el uso.
FACTORS DETERMINE ONLINE RETAIL CLOTHING PURCHASING DECISION OF ONLINE SHOPPER IN COIMBATORE

Nowadays, the rapid development of the Internet and its effect on daily. This study aims to find out the factors that determine online retail clothing purchasing decision of online shopper at Coimbatore. This article overviews and depicts the ingredients that determine online retail clothing purchasing decision or on consumers' online purchase intentions through an in-depth analysis of the relevant literature. Today, the rapid development of the Internet and its effect on daily life has delivered a new consumer profile which is referred to as the ‘online consumer’. Such consumers are impressed by different factors, and they have different purchasing habits when we compare them with traditional consumers. Moreover, this subject is undertaken to understand the behaviors of online shoppers through a self-constructed questionnaire of 150 respondents from Coimbatore. The survey proposed to assess the online buying decision by touching the impact of online purchasing or by researching the impact online purchasing has so far produced. The factors limiting the online buying decision of online shoppers on Coimbatore, India have been further explored to study and find out even the relationship between the availability of the ware and the purchasing decision.
Cytoskeleton and mitosis in the dinoflagellate Crypthecodinium cohnii: immunolocalization of P72, an HSP70-related protein

The intracellular organization of dinoflagellate protists, particularly the cytoskeleton, the cell cycle and mitosis (“dinomitosis”), presents peculiar features governed by specific proteins. We have previously biochemically isolated and characterized a protein of 72 kDa (P72) conserved from dinoflagellates to humans. The microsequencing of the NH2-terminal sequence and the reaction with a monoclonal antibody suggested that this protein belongs to the HSP70 chaperone family (Perret et al. 1991, 1995). Using a polyclonal antibody raised against P72, we have immunolocalized this protein using standard fluorescence microscopy on cryosections, confocal laser scanning microscopy on whole mounted cells and transmission electron microscopy after fast-freeze preparation with or without high pressure during freezing. We have localized P72 in specific dense aggregates at the cortical and centrosome level, in the cytoplasmic channels passing through the nucleus during mitosis and in the cleavage furrow. We completed this study by double labelling with anti-P72/anti-β-tubulin to analyse relationships between P72 and the cytoskeleton and to discuss the possible function of P72.
Issues in Information Systems

Multimedia learning greatly enhanced the learning outcome and experience of learners exposed to it. The proposed study will explore the usefulness of multimedia learning software devised to educate Lebanese pregnant women who have a low level of formal education about pregnancy and early infant care. The study will be based on the media richness theory. It is expected that through media rich programs, communication of information is facilitated, promoting the resolving of indecisiveness and ambiguity that stems out of the lack of knowledge or information about a given a subject and the inability to convey a meaning of what is being said respectively.
Deus versus Machina: How Much Health-supporting Technology Do People Allow Depending on the Severity of the Disease?

: Changes in demographic structures resulting in more and more overburdened healthcare systems require novel solutions for modern societies. Members of aging populations are confronted with an ever increasing presence of diseases and seniors frequently suffer from morbidity, which leads to a higher demand of nursing care on the long run. Bottlenecks in this area can to some extent be relieved by the use of an assistive health-related technology, but its acceptance and use is entirely dependent on the targeted users. This study considers the perspective of severely ill persons regarding their nursing care and application of health-related technology support. Using scenario-based empirical research, participants of an online-study ( N = 585) were confronted with three differently severe diseases and assessed aspects considered relevant for their nursing care and adoption of assistive health-related technologies. Results show signiﬁcantly differing opinions in dependency on the severity of a disease. This study highlights several aspects that represent the perspective of diseased persons and provides valuable insights into accepted use of health-enabling technologies and preferred models of nursing care.
MODELS FOR DISCOVERING SIGNATURE PATTERNS IN DNA SEQUENCES

The knowledge acquisition in biological sequences is a challenge and real hard problem. In this paper, we propose statistical models to discover “Signature Patterns”, which is very significant, small information for identifying types of sequences, from unknowledgeable DNA sequences. The models simply gather all possible n-grams of DNA sequences and then use six statistics-based functions to measure how the n-grams relate to types of sequences. Finally, “signatures” are extracted by selecting the most significant patterns (signatures) by consensus of measured scores. Our experiments showed that the signature patterns generated from too short sequences yield poor performance; while the use of sequences which are longer than a half of complete sequences yields good performance. The six scoring measures are comparably useful, except the “Information Gain” since the use of absent patterns brings unbalanced class and pattern score distribution. Additionally, the experiments on different datasets also showed that precision to identify Influenza virus sequences are over 90%, when the length of patterns is between 6 and 10 and the longer length does not show improvement of precision.
Artificial Intelligence: Fiction, reality and... dreams

I must continue by expressing how honored I feel to receive a medal as special as No. 1 of this Royal Academy, which was deposited by the illustrious academic Mr. Eugenio Andrés Puente, to whom the Academy paid a posthumous tribute on September 25th this year. Professor Andrés Puente was a leading figure in the Industrial Engineers school at the Polytechnic University of Madrid and a pioneer of research in industrial engineering in Spain. In addition to an excellent teaching career and a large scientific production, he stood out for his dedication to the promotion of industrial innovation and his close collaboration with the industry, as is my case. For this reason, he received prestigious awards such as the Encomienda with plaque of the Civil Order of Alfonso X the Wise and the First Merit Cross of the Order of Merit of the Federal Republic of Germany, where he obtained his doctorate. So, I receive this medal, which was his, with a great sense of responsibility and a firm commitment to be worthy of it.
Non-Invasive Corticosterone Treatment Changes Foraging Intensity in Red-Eyed Vireos Vireo olivaceus

Corticosterone is thought to play an important role in food caching and foraging behaviour. However, the direct influence of increased plasma corticosterone on feeding behaviour is still unclear. In this study the effect of increased corticosterone on feeding behaviour in migratory active red-eyed vireos Vireo olivaceus was investigated. We hypothesized that if increased corticosterone levels facilitate foraging behaviour, an increased number of visits to the food bowl by corticosterone treated birds would be seen. In addition to ad lib food during the experiment, the vireos were fed every full hour between 09.00–13.00 h with one meal worm injected either with 4 μg corticosterone dissolved in 20 μl DMSO, or with DMSO only as a control treatment. The presence or absence of a bird in the food bowl was recorded by a motion detector between 09.00–15.00 h. The non-invasive corticosterone treatment increased plasma corticosterone levels and caused vireos to visit the food bowl more frequently compared to control treated individuals between 11.00–12.00 h and 13.00–15.00 h. Our data indicate that corticosterone has an effect on feeding behaviour in birds.
A New Species of Nephroma from North America

Nephroma occultum sp. nov. is described from material collected from treetops in Oregon. This species is in the N. cellulosum group but contains usnic acid. Notes on the chemistry of N. arcticum, N. antarcticum and N. australe are also given. In recent studies of the epiphytes of old conifers in western Oregon by Denison et al. (1972, 1975, 1977), a new species of Nephroma was found in the canopy of large douglas fir trees (Pseudotsuga menziesii (Mirb.) Franco). In these studies of 400-500-year-old trees, the above authors modified and adapted rock and mountain climbing techniques for access to the canopy 60-80 meters above the ground. Among the many lichens and bryo- phytes in the tops of the trees, this Nephroma was only found high up in old trees on moderate-sized branches and never lower on the trunks; thus, it remained hidden in the canopy and was only discovered by the use of innovative techniques developed for study- ing the ecosystem in tree tops.
Transcriptional regulation of Smad2 is required for enhancement of TGFβ/Smad signaling by TGFβ inducible early gene

TGFβ inducible early gene (TIEG) is a novel Krüppel‐like transcriptional repressor that was recently shown to increase the activity of the TGFβ/Smad signal transduction pathway by relieving negative feedback through repression of the inhibitory Smad7. Interestingly, while Smad7 is required for maximal enhancement of TGFβ/Smad signaling, we observe that TIEG is still capable of increasing Smad pathway activity in the absence of Smad7. Furthermore, while Smad7 is known to block both TGFβ and bone morphogenetic protein (BMP) signaling, we observe that TIEG specifically enhances only the TGFβ pathway. Similarly, while both TIEG and the related Krüppel‐like factor, FKLF2, repress Smad7 transcription, only TIEG is capable of enhancing Smad signaling. In order to identify additional regulatory targets of TIEG important for this enhancement of the Smad pathway activity, we performed microarray analysis and identified Smad2 as a TIEG target gene. We now show evidence that TIEG increases transcription of the Smad2 gene but not the Smad3 or Smad4 genes. Furthermore, while the TGFβ/Smad pathway remains intact in Smad2 null cells, TIEG enhancement of Smad signaling is dramatically reduced. Thus we propose a new model whereby TIEG enhances Smad signaling by a dual mechanism involving both the repression of the inhibitory Smad7 as well as the activation of Smad2. J. Cell. Biochem. 87: 233–241, 2002. © 2002 Wiley‐Liss, Inc.
Automatically Prospecting Feature for Queries from Their Search Impact

We recommend that you compile the duplicate lists in the top search engine results to track the aspects of the query and implement a method known as QDMiner. More specifically, QDMiner extracts free text lists, HTML tags and reregions the top search engine results, combining them with groups according to the products they contain, then line up the blocks and products, depending on how the conversation and products are included in the best results. The recommended approach is generic and does not depend on understanding any area. The main purpose of the extraction side differs from the query recommendations. We recommend a structured solution, described as QDMiner, to trace query aspects immediately by removing and grouping repetitive lists in free text results and HTML tags and repeating search engines. We continue to evaluate the support of the list and discover better search queries by looking for exact similarities between menus and penalizing duplicate lists. Experimental results reveal that there are many listings available and QDMiner can find useful queries. The proposed approach is general and does not depend on understanding a particular area. As a result, it can handle opendomain queries. The query supports. Instead of a static system for your problems, we extract the sides of the uploaded document above each query
INDICATORS OF SUSTAINABLE AGRICULTURE

Agricultural production is based on the exploitation of biological resources (plants and animals). Their basic characteristic is the ability for renewal. Namely, since biological resources possess reproduction ability, they are considered to by inexhaustible. However, the development of civilization, innovative technologies in all human activities, current trends in growing only high-yielding species, strains, cultivars, races and hybrids, long-term unilateral selection for high productivity, development of the so-called agrotechopathies, increasing population numbers, as well as the resulting steady pollution of ecosystems have imposed the necessity for defining stable, sustainable and organic agricultural production and for determining indicators of its stability. Key-Words: -Indicators, Sustainable agriculture, Organic agriculture, Agrobiodiversity, Pollution of ecosystems
Species richness of insects and mites on trees: expanding Southwood

Summary 1 Data on the species richness of phytophagous insects and mites associated with 25 tree genera occurring as natives in Germany were compiled and compared to data for British trees published by Kennedy & Southwood (1984). For tree genera occurring in Germany and Britain patterns of species richness and composition of phytophage faunas were similar. 2 Present abundance of trees, their distributional history during the Holocene, morphological traits and taxonomic isolation were used to explain the variance of species richness and proportion of specialists across tree genera occurring as natives in Germany. Tree genera were either used as independent data points or to calculate phylogenetically independent contrasts. For the latter approach, a phylogeny for the tree genera was generated from published rbcL gene sequences. In general, the conclusions from the two types of analyses were similar. 3 The species richness of phytophages on German tree genera were positively related to present tree abundance, tree height and tree abundance derived from pollen samples. For phylogenetically independent contrasts the length of time a genus was present since the end of the last glaciation also became significant. 4 The proportions of specialists showed a negative relationship with present abundance of trees, a positive relationship with taxonomic isolation as well as the length of time of genus was present since the end of the last glaciation. For phylogenetically independent contrasts only the latter two variables remained significant. 6 Overall the results support the species–area and the coevolutionary hypotheses.
Niche Response Structure and the Analytical Potentials of Its Relationship to the Habitat

A system reacts to kinds and/or levels of environmental conditions by producing a response which is a function of those conditions. (The response may vary from passivity, to change or dissolution of the system.) This paper suggests an approach to systems in general, and uses the species (entire species, species population, or individual) as an example of such a system. The niche is considered to represent the response structure of this system. This response structure is then related to environmental conditions to make possible valuable intuitive as well as quantitative, analytical, and modeling approaches to ecological, evolutionary, and other kinds of processes. Simplified examples and models are given to illustrate the utilization of this approach toward the analysis and understanding of the processes of population growth, competition, and prey-predator interaction. Suggestions are made concerning how the approach can be used to model and understand the effects of lags which occur in the feedback systems of ecological processes and how it may be used to illuminate problems of succession, geographic variation, population genetics, both physiological and genetic adaptation (evolution), and others. In addition, if the niche or other system response structure is well enough known, then measurement of system response can be used to study the environment and/or the system-environment complex. Economic, psychological, educational, sociological, urban, human life quality, electrical, chemical, mechanical, and other systems and their processes are amenable to the same intuitive and analytical approaches as have been demonstrated and suggested here for species their response structures, and their processes (competition, predation, succession, evolution, etc.). I would greatly appreciate any comments, suggestions, or references to data, which will assist in the evaluation of the further development of this approach toward better analysis and understanding of ecological and other systems.
DEVELOPMENT OF A DNA SAMPLING KIT TO DETECT PATHOGENIC, SAPROTROPHIC, AND STAN FUNGI IN SAPWOOD OF DECLINING RED PINE (PINUS RESINOSA) IN THE UPPER MIDWEST

An inexpensive kit was developed to collect wood samples for molecular detection of pathogenic, saprotrophic and stain fungi in declining Pinus resinosa in the Upper Midwest. The kit contained materials for “clean” collection of sapwood drill shavings, which were then subjected to PCR of the rDNA ITS region with fungal-specific primers, followed by cloning and sequencing. Twenty-seven stands with declining P. resinosa lacking obvious fungal fruiting bodies were sampled by natural resources personnel throughout MN, WI, and MI. No single mortality agent predominated and causal agent(s) likely differed by location. A complex interaction of abiotic and biotic agents is likely involved in the symptomatic stands. None of the selected trees tested positive for Heterobasidion irregulare with either a pathogen-specific primer or more general ITS primers. Root rot fungi that were detected in the declining and dead trees included Armillaria solidipes (= A. ostoyae), Scytinostroma sp. , and two species of Leptographium, the genus associated with Red Pine Pocket Mortality. The brown rot fungi Coniophora arida and C. puteana, known to cause root and butt rots in conifers in the western U.S., were found on both living, declining trees and dead snags. Many ophiostomoid sapstain fungi were present and were usually associated with signs of insect activity. Saprotrophic decay fungi were prevalent with white rot fungi predominating, including Amylostereum chailletii, Hyphoderma setigerum, Hypholoma fasiculare, and Trichaptum fuscoviolaceum. Numerous ascomycetes, including endophytic fungi and yeasts, were recovered in great quantities; many of these were uncommon and site specific. Thirty-two unique sequences from basidiomycetes and 129 from ascomycetes had no species, genus, or family identification in GenBank, illustrating the complex and largely unstudied community of fungi found in declining P. resinosa. The procedures presented here can be used to address questions of fungal diversity and ecology as well as forest pathology, and the technique can be easily adapted to screening with species specific primers when screening for individual pathogens, thus reducing cost and labor.
Prediction of Crop and Weed Growth Stages using Neural Network in Machine Learning

This paper presents the structure, usage and assessment of a convolutional neural system-based methodology has been applied for the arrangement of various phenological phases of plants. Our CNN design can consequently characterize distinctive phenological phases of eleven sorts of plants. So as to assess the presentation and productivity of our profound learning-based methodology, an old-style AI approach dependent on physically removed highlights is additionally executed. Textural highlights dependent on GLCM highlights have been removed and joined arrangement of highlights are taken care of into an AI calculation. The arrangement pace of the methodology dependent on physically extricated highlights is contrasted with those of our CNN based methodology. Trial results demonstrate that CNN put together methodology is fundamentally powerful with respect to the eleven sorts of plants we investigated. There are a wide range of ways profound learning can be applied on a dataset relying upon the size of the dataset. There are many research headings that we are intending to take for arranging phenological stages. Future work may comprise of building our own CNN design without any preparation especially prepared for arranging phenological phases of plants, just as trying different things with other pre-prepared CNN models and making sense of an approach to recognize infections in crops.