Miracle-dz/UniFAR-FTUs huggingface dataset:
The Antisignaling Agent SC- (cid:1)(cid:1)(cid:2) 9, 4-(Benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)-2-decanoylaminobutyricAcid,IsaStructurallyUniquePhospholipidAnaloguewithPhospholipaseCInhibitoryActivity

Phospholipids and lipid second messengers mediate mitogenic signal transduction and oncogenesis, but there have been few successful examples of small molecules that affect biologically important phospholipid metabolism. Here we investigated the actions of a previously described antitumor agent, 4-(benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)-2- decanoylaminobutyric acid (SC- (cid:1)(cid:1)(cid:2) 9), which has antisignaling properties, on phospholipases. Although SC- (cid:1)(cid:1)(cid:2) 9 had been shown to be a potent and selective inhibitor of the Cdc25 family of dual-specificity phosphatases, many of its cellular effects are not readily reconciled with phosphatase inhibition. Molecular modeling studies suggested that SC- (cid:1)(cid:1)(cid:2) 9 shared several structural features with membrane phospholipids. Enzyme inhibition studies in vitro revealed that SC- (cid:1)(cid:1)(cid:2) 9 was a potent inhibitor of phospholipase C (PLC; IC 50 (cid:3) 25 (cid:4) M ) but did not inhibit phospholipase D activity at concentrations up to 100 (cid:4) M . In H- ras (Q61L)-transformed Rat-1 fibroblasts with constitutively elevated levels of phosphorylated extracellular signal-regulated kinase (Erk), SC- (cid:1)(cid:1)(cid:2) 9 inhibited both proliferation and oncogenic Erk activation at concentrations that inhibited PLC in vitro . A SC- (cid:1)(cid:1)(cid:2) 9 congener that lacked antiproliferative activity also did not inhibit PLC in vitro . In the PLC-dependent scratch wound healing model, SC- (cid:1)(cid:1)(cid:2) 9 was 10-fold more potent than the phosphatidylcholine-specific PLC inhibitor D-609. We propose that the structural resemblance of SC- (cid:1)(cid:1)(cid:2) 9 to phospholipids allows it to inhibit cellular PLC, thereby providing a possible molecular mechanism for SC- (cid:1)(cid:1)(cid:2) 9’s effects on oncogenic Erk activation.
Acoustic Sensor Network for Vehicle Trafﬁc Monitoring

—Real time trafﬁc monitoring is a fundamental requirement for improving the efﬁciency of transportation systems. The emerging technology of wireless sensor networks (WSNs) allows of distributed trafﬁc monitoring systems at large scale with low cost of installation and maintenance. The develop of cheap sensor nodes with integrated computing and wireless communication capabilities has changed the scenery of real-time trafﬁc data acquisition. This paper describes a WSN based on an array of acoustic sensor employing an effective signal processing and a novel parameter estimation procedure. Key features are trafﬁc monitoring and localization of trafﬁc congestion event performed in real time, with an impressive space scale. A particular case study is presented starting from a real problem and achieving the best architectural solution. Finally the results of theoretical analysis and extensive experimental results of a prototype installation on a motorway are provided.
Adaptive introgression facilitate adaptation to high latitudes in European aspen

Understanding local adaptation has become a key research area given the ongoing climate challenge and 31 the concomitant requirement to conserve genetic resources. Perennial plants, such as forest trees, are 32 good models to study local adaptation given their wide geographic distribution, largely outcrossing 33 mating systems and demographic histories. We evaluated signatures of local adaptation in European 34 aspen ( Populus tremula ) across Europe by means of whole genome re-sequencing of a collection of 411 35 individual trees. We dissected admixture patterns between aspen lineages and observed a strong genomic 36 mosaicism in Scandinavian trees, evidencing different colonization trajectories into the peninsula from 37 Russia, Central and Western Europe. As a consequence of the secondary contacts between populations 38 after the last glacial maximum (LGM), we detected an adaptive introgression event in a genome region 39 of ~500kb in chromosome 10, harboring a large-effect locus that has previously been shown to 40 contribute to adaptation to the short growing seasons characteristic of northern Scandinavia. 41 Demographic simulations and ancestry inference suggest an Eastern origin - probably Russian - of the 42 adaptive Nordic allele which nowadays is present in a homozygous state at the north of Scandinavia. The 43 strength of introgression and positive selection signatures in this region is a unique feature in the 44 genome. Furthermore, we detected signals of balancing selection, shared across regional populations, that highlight the importance of standing variation as a primary source of alleles that facilitate local adaptation. Our results therefore emphasize the importance of migration-selection balance underlying the 47 genetic architecture of key adaptive quantitative traits.
The Young and Nearby Normal Type Ia Supernova 2018 gv : UV-Optical Observations and the Earliest

The non-detection of companion stars in Type Ia supernova (SN) progenitor systems lends support to the notion of double-degenerate (DD) systems and explosions triggered by the merging of two white dwarfs. This very asymmetric process should lead to a conspicuous polarimetric signature. By contrast, observations consistently find very low continuum polarization as the signatures from the explosion process largely dominate over the pre-explosion configuration within several days. Critical information about the interaction of the ejecta with a companion and any circumstellar matter is encoded in the early polarization spectra. In this study, we obtain spectropolarimetry of SN2018gv with the ESO Very Large Telescope at −13.6 days relative to the B−band maximum light, or ∼5 days after the estimated explosion — the earliest spectropolarimetric observations to date of any Type Ia SN. These early observations still show a low continuum polarization (.0.2%) and moderate line polarization (0.30±0.04% for the prominent Si II λ6355 feature and 0.85±0.04% for the high-velocity Ca component). The high degree of spherical symmetry implied by the low line and continuum polarization at this early epoch is consistent with explosion models of delayed detonations and is inconsistent with the merger-induced explosion scenario. The dense UV and optical photometry and optical spectroscopy within the first ∼100 days after the maximum light indicate that SN2018gv is a normal Type Ia SN with similar spectrophotometric behavior to SN2011fe.
Characterization and functional analysis of the b -1,3-glucanosyltransferase 3 of the human pathogenic fungus Paracoccidioidesbrasiliensis

The fungus Paracoccidioides brasiliensis causes paracoccidioidomycosis, a systemic granulomatous mycosis prevalent in Latin America. In an effort to elucidate the molecular mechanisms involved in fungus cell wall assembly and morphogenesis, b -1,3-glucanosyltransferase 3 ( Pb Gel3p) is presented here. Pb Gel3p presented functional similarity to the glucan-elongating/glycophospholipid-anchored sur-face/pH-regulated /essential for pseudohyphal development protein families, which are involved in fungal cell wall biosynthesis and morphogenesis. The full-length cDNA and gene were obtained. Southern blot and in silico analysis suggested that there is one copy of the gene in P. brasiliensis . The recombinant Pb Gel3p was overexpressed in Escherichia coli , and a polyclonal antibody was obtained. The PbGEL3 mRNA, as well as the protein, was detected at the highest level in the mycelium phase. The protein was immunolocalized at the surface in both the mycelium and the yeast phases. We addressed the potential role of Pb Gel3p in cell wall biosynthesis and morphogenesis by assessing its ability to rescue the phenotype of the Saccharomyces cerevisiae gas1 D mutant. The results indicated that Pb Gel3p is a cell wall-associated protein that probably works as a b -1,3-glucan elongase capable of mediating fungal cell wall integrity.
ASTM F138 Steel Metallurgical Characterization and CTOD Analysis Applicable to Orthopedic Implants

The purpose of this paper is to verify the proceedings of the fracture toughness test CTOD applied to austenitic stainless steel F138, commonly used for orthopedic implants. A metallurgical characterization of sample materials was performed in which chemical composition analysis, micrographs, micro Vickers hardness tests, inclusion analysis, and scanning electron microscopy were also evaluated. In order to illustrate the technique, some rejected samples by the quality control from different suppliers were obtained and tested. This study was based on procedures governed by standards [1,2] which regulate the performance of CTOD toughness tests, with the purpose of evaluating the mechanical resistance and useful life of prosthetics. The standard [3] governing the basic properties of materials accepted for prosthetic production has also been studied. identified the micro mechanisms present the test and the crack opening;
Finding Rare Information from the Web Using Social Bookmarks and Word Co-occurrence 1

: We propose methods to find rare information from the Web using two approaches. We define rare information as relevant and atypical information. In the first approach, we use social bookmark data. Especially, we focus on tags which are sometimes used to annotate topics of the pages. The second approach is based on word co-occurrence in a corpus. In both approaches, we use conditional probabilities to express relevancy and atypicality. In experiments, we compared our methods with the relevance-oriented method, the diversity-oriented method, and another rarity-oriented method. We prepared typical and atypical pages for ten queries, and ranked them using each method. Our methods using word co-occurrence obtained better nDCG scores than the other methods.
Impact of Empowerment on Employee’s Psychological Wellbeing

Empowerment as a positive triggering instrument in employees which is also considered an integral and vital part of employee‟s psychological wellbeing. Empowerment results in productivity, satisfaction and determination of the employees working for an organization provided that it is properly monitored and there is a check and balance system. Psychological well-being includes the wellness and fitness and well-being of particular people in the office. Quantitative research was carried out with the aim to find the impact of empowerment on employee‟s psychological wellbeing. Adopted questionnaire was used for the collection of primary data. Random sample techniques were used. In this regards, data was collected from 50 executive level employees of Pakistan State Oil and Attock Refinery Limited. Two hypotheses were tested by using regression analysis. The value of R shows . 461 correlations between empowerment and psychological wellbeing. R 2 shows the impact of empowerment (Independent variable) on psychological wellbeing (Dependent variable). According to the results of regression, Model1 (F = 12.924, p<0.001), were statistically signiﬁcant. The coefficient of empowerment was positive and significant at 1 percent. It means that empowerment has statistically significant impact on Psychological wellbeing. The value of F statistics is about 13 and the P value 0.00 it means that the model was fit to predict. The value R² is 21 percent states that about 21 percent change in the psychological employee wellbeing is due to the empowerment, the remaining 79 percent changes in the employee psychological wellbeing is due to other factors which is unexplained by this model. So the analysis reject the null hypothesis that sate that empowerment has no impact on employee psychological wellbeing. And accepted alternative hypothesis of this study which was “Empowerment have positive impact on Employee Psychological Wellbeing”. Company identified a positive relationship between empowerment and psychological wellbeing. The finding of this study shows that company should empower employees to give them that psychological feeling is being committed to the organization. Committed to an organization is strength because psychological empowerment plays a vital role in commitment of employees towards that every organization.
Automatic Identiﬁcation of Cohesive Structures within Modularity Reengineering

—The quality of software systems depends heavily on the quality of their structure, which affects maintainability and readability. To improve the quality of structure, a system can be restructured. This paper describes a restructuring process, which uses a combination of strongly connected component analysis, dominance analysis, and intra-modular similarity clustering to identify and preserve structures that have been thoughtfully placed together, but would be separated by pure metric-based or similarity-based techniques. The use of the proposed method allows a signiﬁcant reduction of the number of components that should be moved. Therefore, the number of false movements is alleviated. The proposed approach was implemented in a prototype and illustrated by statistics and examples from 18 open source Java projects. A coherence metric is introduced to further improve restructuring results.
A monostable piezoelectric energy harvester for broadband low-level excitations

This letter presents a monostable piezoelectric energy harvester (PEH) for achieving enhanced energy extraction from low-level excitations. The proposed PEH is realized by introducing symmetric magnetic attraction to a piezoelectric cantilever beam and a pair of stoppers to confine the maximum deflection of the beam. The lumped parameter model of such a system is presented and experimentally validated. Theoretical simulations and experimental measurements demonstrate that the proposed design can bring about a wider operating bandwidth and higher output voltage than the linear PEH. Under a sinusoidal vibration with an amplitude of 3 m/s2, a 54% increase in the operating bandwidth and a 253% increase in the magnitude of output power are achieved compared to its linear counterpart. Moreover, the proposed PEH exhibits rich dynamic features, including the tunable operating bandwidth, adjustable voltage and power levels, and softening hysteresis.This letter presents a monostable piezoelectric energy harvester (PEH) for achieving enhanced energy extraction from low-level excitations. The proposed PEH is realized by introducing symmetric magnetic attraction to a piezoelectric cantilever beam and a pair of stoppers to confine the maximum deflection of the beam. The lumped parameter model of such a system is presented and experimentally validated. Theoretical simulations and experimental measurements demonstrate that the proposed design can bring about a wider operating bandwidth and higher output voltage than the linear PEH. Under a sinusoidal vibration with an amplitude of 3 m/s2, a 54% increase in the operating bandwidth and a 253% increase in the magnitude of output power are achieved compared to its linear counterpart. Moreover, the proposed PEH exhibits rich dynamic features, including the tunable operating bandwidth, adjustable voltage and power levels, and softening hysteresis.
Preliminary Test Suite Reduction

—Test suite reduction is an activity which reduces test suites while maintaining their coverage properties. This problem is equivalent to the set covering problem and therefore NP-complete. Many strategies for solving the problem are known. They are usually applied to minimizing the number of action calls within a given test suite for a certain coverage goal. While some algorithms like branch and bound compute an exact minimal solution, other algorithms like the greedy approach compute an approximation for the minimal set of actions. In this work, we deal with the problem of eﬃcient test suite reduction in industrial practice. For this purpose, we introduce the concept of preliminary test suite reduction. Its aim is to reduce redundancy in test suites before starting the actual reduction. In the paper, we further describe experimental results that give implication on how the proposed technique can reduce the runtime of test suite reduction in the industrial practice.
A template-free metal-etching-oxidation method to synthesize aligned oxide nanowire arrays: NiO as an example

eterministic synthesis of one-dimensional (1D) crystalline nanowires ABSTRACT Although NiO is one of the canonical functional binary oxides, there has been no report so far on the effective fabrication of aligned single crystalline NiO nanowire arrays. Here we report a novel vapor-based metal-etching-oxidation method to synthesize high-quality NiO nanowire arrays with good vertical alignment and morphology control. In this method, Ni foils are used as both the substrates and the nickel source; NiCl 2 powder serves as the additional Ni source and provides Cl 2 to initiate mild etching. No template is deliberately employed; instead a nanograined NiO scale formed on the NiO foil guides the vapor inﬁltration and assists the self-assembled growth of NiO nanowires via a novel process comprising simultaneous Cl 2 etching and gentle oxidation. Furthermore, CoO and Co-doped NiO as examples, we show that this general method can be employed to produce nanowires of other oxides as well as the doped counterparts.
In-Vitro and In-Vivo Pathogenicity of Mar, Biofilm Forming Non-Cholera Vibrios (NCV) From Asian Tiger Shrimp ( Penaeus monodon ): Implications for Food Safety and Sanitation

Contamination of aquatic environment with antibiotic resistant bacteria is a multi-factorial global threat with deleterious effects on human and animal health. In this preliminary study, we examined the in-vitro susceptibility of 14 antibiotics against 4 biofilm forming non-cholera Vibrios , ( Vibrio alginolyticus and Vibrio parahemolyticus ) isolated from fresh and healthy Asian Tiger Shrimp ( Penaeus monodon ), sourced from retail fish markets in Cochin during a three-month period. Biofilm forming capacities were evaluated by qualitative and quantitative assays as well as by characterization of biofilms under different food related stress conditions. Growth temperature and NaCl concentration influenced biofilm formation profoundly. Antibiotic resistance/susceptibility profiles of 4 biofilm formers assessed by Kirby-Bauer disc diffusion method, showed resistance to 13 of the 14 antibiotics tested. The pathogenicity profile of the isolates was elucidated by in-vitro assays like exo-enzyme profiling, auto-aggregation and surface hydrophobicity. In addition, a Caenorhabditis elegans based in-vivo pathogenicity testing by survival score analysis was also included. All these findings reveal that shrimp or related seafood harbors antibiotic resistant, biofilm forming Vibrios , indicating high-risk of food-related illnesses in humans. Further understanding of these processes will provide novel insights into the therapeutics and prevention of biofilm-related Vibrio infections in the aquaculture/seafood industry. to study ‘host pathogen interactions’ using Caenorhabditis elegans as a resourceful This pilot study was undertaken to evaluate antibiotic susceptibility and virulence potential of biofilm forming NCV’s from
Big data analysis on online TV - Predict likes in FaceBook

Online video is a powerful way to communicate or express any brand story, explain business value proposition clearly, and build relationships with your customers and prospects better than any other means. Recent statistics shows that including video on a landing page can increase conversion rates by 80%? Or that 92% of mobile video consumers share videos with others. Other stats show video is shared 1200% more than both links and text combined. Hence, video content is a powerful tool for any brand. The most popular ways to take video online are YouTube channels and Facebook pages. It is critical for business to track how their videos are performing. Both Facebook and YouTube provide enormous data on videos in their platform from video views, unique video views, the average duration of the video view and audience retention. We studied related work done in predicting no. of likes in Facebook and experimented our new predicting system on various scenarios and observed lot of interesting facts.
Broadening and deepening the understanding of agency in dementia

Agency has become an essential component of discussions concerning selfhood, well-being, and care in dementia studies but the concept itself is rarely clearly defined and the use of this term can be confusing and conflicting. This paper outlines some of the key ways in which agency has been conceptualised in relation to dementia, highlighting the complexities surrounding this concept and focusing on agency in a way that is tied to our ideas about citizenship, legal and human rights. Seven key dimensions of agency are examined: embodiment, emotions, sense of agency, intentional conscious action, the social context of agency, decision-making and moral responsibility. Using a critical realist approach, this paper brings together the diverse ways in which agency has been understood into an interdisciplinary, laminated understanding of agency. This model is then used in an applied example demonstrating that this model can be used to identify the ways in which an arts intervention can support the agency of people living with dementia. This paper proposes that agency is layered, multidimensional and exists on a continuum.
Genomic prediction for canopy height and dry matter yield in alfalfa using family bulks

Genomic selection (GS) has proven to be an effective method to increase genetic gain rates and accelerate breeding cycles in many crop species. However, its implementation requires large investments to phenotype of the training population and for routine genotyping. Alfalfa (Medicago sativa L.) is one of the major cultivated forage legumes, showing high‐quality nutritional value. Alfalfa breeding is usually carried out by phenotypic recurrent selection and is commonly done at the family level. The application of GS in alfalfa could be simplified and less costly by genotyping and phenotyping families in bulks. For this study, an alfalfa reference population composed of 142 full‐sib and 35 half‐sib families was bulk‐genotyped using target enrichment sequencing and phenotyped for dry matter yield (DMY) and canopy height (CH) in Florida, USA. Genotyping of the family bulks with 17,707 targeted probes resulted in 114,945 single‐nucleotide polymorphisms. The markers revealed a population structure that matched the mating design, and the linkage disequilibrium slowly decayed in this breeding population. After exploring multiple prediction scenarios, a strategy was proposed including data from multiple harvests and accounting for the G×E in the training population, which led to a higher predictive ability of up to 38 and 24% for DMY and CH, respectively. Although this study focused on the implementation of GS in alfalfa families, the bulk methodology and the prediction schemes used herein could guide future studies in alfalfa and other crops bred in bulks.