Miracle-dz/UniFAR-FTUs huggingface dataset:
Palbociclib in Patients With Non-Small-Cell Lung Cancer With CDKN2A Alterations: Results From the Targeted Agent and Profiling Utilization Registry Study.

PURPOSE The Targeted Agent and Profiling Utilization Registry (TAPUR) Study is a phase II pragmatic basket trial evaluating antitumor activity of commercially available targeted agents in patients with advanced cancer with genomic alterations known to be drug targets. Results in a cohort of patients with non-small-cell lung cancer (NSCLC) with CDKN2A alterations treated with palbociclib are reported. METHODS Eligible patients were ≥ 18 years old with advanced NSCLC, no remaining standard treatment options, measurable disease, Eastern Cooperative Oncology Group performance status of 0 to 2, and adequate organ function. Patients with NSCLC with CDKN2A alterations and no Rb mutations received palbociclib 125 mg orally once daily for 21 days, followed by 7 days off. Simon's two-stage design was used with a primary study end point of objective response or stable disease (SD) of at least 16 weeks in duration. Secondary end points are progression-free survival (PFS), overall survival (OS), and safety. RESULTS Twenty-nine patients were enrolled from January 2017 to June 2018; two patients were not evaluable for response but were included in safety analyses. One patient with partial response and six patients with SD were observed, for a disease control rate of 31% (90% CI, 19% to 40%). Median PFS was 8.1 weeks (95% CI, 7.1 to 16.0 weeks), and median OS was 21.6 weeks (95% CI, 14.1 to 41.1 weeks). Eleven patients had at least 1 grade 3 or 4 adverse event (AE) or serious AE (SAE) possibly related to palbociclib (most common, cytopenias). Other AEs or SAEs possibly related to the treatment included anorexia, fatigue, febrile neutropenia, hypophosphatemia, sepsis, and vomiting. CONCLUSION Palbociclib monotherapy demonstrated evidence of modest antitumor activity in heavily pretreated patients with NSCLC with CDKN2A alterations. Additional investigation is necessary to confirm efficacy and utility of palbociclib in this population.
Cultivation of two species of Spirulina (Spirulina platensis and Spirulina platensis var lonar) on sea water medium and extraction of C-phycocyanin

Spirulina has been cultivated worldwide for their c ommercially valuable products like crude protein, b io-pigments and other food supplements. Commercial Spirulina Pr oducers tired to cultivate it in cheap natural reso urces and thus reduce the cost of production and environmenta l pollutions. In this experiment there were two spe cies of Spirulina viz., Spirulina platensis (filamentous ty pe) and Spirulina platensis var lonar has been trie d to cultivate on cultivation medium formulated with sea water. The cwas carried out for a period of 15 days, at 27 °C and at constant light intensity of 1.7 klux. The physic o-chemical characteristics of seawater were analyze d before media formulation as per the standard protocols provided by American Public Health Association (APHA-1989). The growth of the microalgae was monitored by Direct Mi croscopic Count (DMC), Optical Density (OD) at 560n m and Biomass estimation. The generation time of the two micro-algae and their C-phycocyanin yield in contro l as well as seawater media were also determined. The results re vealed that the sea water medium forms better alter native natural cheap resource to cultivate the Spirulina. As for as biomass yield is concern, the Spirulina p latensis (filamentous type) provided increased yield (2.72g/ l) when compared to the control (2.48g/l) (Zarrouk) medium.
Mitochondrial D-loop analysis reveals single maternal lineage for coastal region goats of India

D-loop is important for evaluating the diversity and relatedness among the breeds in different geographic locations. The D-loop region has not been studied and the relatedness is not known among Indian goat populations on this basis. In the present study, we sequenced and analyzed 835bp mitochondrial DNA D-loop sequences in 95 samples of 3 coastal regions and one semi-arid region of India as an out-group and identified 68 haplotypes with 92 polymorphic sites. All goat populations in this study were highly diverse on the basis of haplotype and nucleotide diversity. Analysis of molecular variance revealed large genetic differentiation within the populations. We implemented neutrality tests to assess recent historical demographic events. Tajima’s D test and Fu’s Fs test both suggested recent population growth for the populations. The network analysis revealed high levels of singleton haplotypes in the goat populations of coastal regions and semi-arid regions of India and deciphered a single maternal lineage.
Physical attractiveness and reproductive success in humans: evidence from the late 20th century United States

Physical attractiveness has been associated with mating behavior, but its role in reproductive success of contemporary humans has received surprisingly little attention. In the Wisconsin Longitudinal Study (1244 women, 997 men born between 1937 and 1940), we examined whether attractiveness assessed from photographs taken at age ∼18 years predicted the number of biological children at age 53–56 years. In women, attractiveness predicted higher reproductive success in a nonlinear fashion, so that attractive (second highest quartile) women had 16% and very attractive (highest quartile) women 6% more children than their less attractive counterparts. In men, there was a threshold effect so that men in the lowest attractiveness quartile had 13% fewer children than others who did not differ from each other in the average number of children. These associations were partly but not completely accounted for by attractive participants' increased marriage probability. A linear regression analysis indicated relatively weak directional selection gradient for attractiveness (β=0.06 in women, β=0.07 in men). These findings indicate that physical attractiveness may be associated with reproductive success in humans living in industrialized settings. © 2009 Elsevier Inc. All rights reserved.
Genotypic and Phenotypic Variation among Pepper Accessions Resistant to Phytophthora capsici

Developing high levels of resistance to Phytophthora blight (Phytophthora capsici Leonian) of pepper (Capsicum annuum L.) is a goal of many pepper breeding programs. Genetic diversity and plant characteristics were evaluated on 21 pepper accessions previously identified as having high levels of Phytophthora root rot resistance. Accessions were evaluated for plant height, fruit size and shape, pericarp thickness, and pungency. Accessions varied widely from very unadapted material to those with more obvious breeding potential. Genetic diversity among the accessions was estimated using 22 simple sequence repeat (SSR) loci. Phytophthora capsici resistant accessions were identified that were not closely related to previously described sources of resistance. This information will allow breeders and researchers to further identify and incorporate novel sources of resistance to P. capsici into breeding programs. Accessions PI 201237 and PI 640532 appear to have the most potential for introgressing P. capcisi resistance into bell pepper.
Effect of Time of Harvest on Fruit Size, Yield and Trunk Starch Concentrations of 'Fuerte' Avocados

Fruit from cv. 'Fuerte' avocado (Persea americana Mill) trees were harvested at different stages of maturity judged by flesh dry matter (DM). Treatments included strip-picking trees when fruit reached 21 (the minimum legal standard for avocados in Australia), 24 and 30% DM as well as two other treatments where 50% of the fruit was picked when they reached 21 and 24% DM, respectively, with the balance harvested from these trees at 30% DM. The treatments were applied to the same trees for 3 consecutive years. The seasonal flux of trunk starch concentration was monitored in each of the treatments and the data for the first year of the experiment are presented. Strip-picking of the trees at 21% and 24% DM, and where 50% of the crop was harvested at 21% DM with the balance at 30% DM, produced about 3.6 t/ha more fruit annually (averaged over the three years) than from those trees harvested when fruit was more mature. The later harvesting of fruit, viz. the crop picked at 30% DM, resulted in pronounced biennial cropping over the 3 years studied. Mean fruit size was significantly greater from those trees where 50% of the fruit were previously harvested at 24% DM with the balance at 30% DM as well as where fruit were harvested after reaching 30% DM compared to fruit from trees which were strip-picked at 21 and 24% DM (about 345 vs. 304 g). Trunk starch concentrations ranged between 4.5 to 6.3% during the time of active tree and fruit growth. In all treatments, except where the crop was left on the tree until 30% DM, the trunk starch concentration rose to about 7.7% in late winter prior to flowering. The treatment harvested late had a trunk starch concentration of 5.3%. During flowering and fruit set the flux of trunk starch concentrations was negatively correlated to the respective flowering and fruit retention performance of the treatments. Biennial bearing in fruit tree crops is a persistent problem which by no means has been resolved. While many of the fundamental physiological principles extend over all fruit tree crops, the evergreen trees have a vastly different phenology compared to deciduous trees which creates specific problems in relation to flowering and fruiting. For instance, it is not uncommon for evergreen trees to be carrying fruit while flowering,
Kinetics of ethylene biosynthesis and its effects during maturation of white spruce somatic embryos

The objective of the current investigation was to study the role of ethylene in the maturation of white spruce (Picea glauca [Moench.] Voss) somatic embryos. This was carried out by examining the effects of (1) 1-aminocyclopropane-1-carboxylic acid (ACC), a direct precursor of ethylene in plant tissue, (2) silver nitrate (AgNO 3 ), an inhibitor of ethylene action, (3) α-aminooxyamino acid (AOA), a potent inhibitor of ethylene biosynthesis, and (4) enrichment with ethylene. Ethylene biosynthesis was biphasic and gradually increased during embryo development, whereas endogenous ACC and N-malonylaminocyclopropane-1-carboxylic acid (mACC) decreased. Addition of ACC or AOA to the culture medium increased or decreased, respectively, ethylene biosynthesis by altering endogenous ACC levels during the culture period. In contrast to AOA and AgNO 3 , ACC and ethylene enrichment significantly decreased the production of mature somatic embryos and increased the browning of the cultures. However, the structure of the shoot apex in mature cotyledonary stage embryos formed under ethylene enrichment was similar to that in control systems. This shows that a reduction in ethylene is beneficial to maturation of white spruce somatic embryos. This is further substantiated by the finding that the inhibitory effects of AOA were partially reversed by the addition of ethylene. The possible effects of the interaction between ethylene and polyamines on somatic embryo development are also discussed.
Light Micro and Ultrastructural Studies on the Coagulating Gland of Albino Rat (Rscopic and rattus Norvegicus)

The coagulating gland in the rat was compound tubular accessory sex gland. The parenchyma consisted of the secretory units and ducts lined by simple cuboidal or low columnar epithelium which formed folds inside the compartments. The secretory activity was merocrine and apocrine. Ultrastructural study revealed secretory cells of different electron density. These cells had oval nuclei with small nucleoli and the peripheral chromatin. In the cytoplasm, the endoplasmic reticulum was mostly located in the perinuclear area and was granular having studded with ribosomes. The mitochondria, smooth endoplasmic reticulum and the Golgi apparatus were also observed at various locations. The cytoplasm also contained the secretory granules and the vacuoles of different sizes towards the luminal side. The luminal surface had the surface microvilli.
A test for multidimensional reducible diffusion models

We develop a test for multidimensional diffusion models with known drift term based on transformation of diffusion matrix. The test in this article is different from the traditional method. We use a one-to-one transformation to transform the original model into a unit diffusion. Our approach is not only effective for stationary processes. On the other hand, our test performs well both on size and power.
Plant species responses along a grazing disturbance gradient in Australian grassland

Floristic data from paired roadside-paddock analyses from grassland in central Queensland, Australia, were ordinated. The mean direction of the vectors between these pairs was almost perfectly aligned with the indirect gradient represented by the first axis of Non-metric Multi-dimensional Scaling. It confirms anecdotal evidence of a trend from infrequently grazed roadsides to constantly grazed paddocks. The increasing abundance of annual herbs and grasses along this putative gradient is consistent with documented trends from elsewhere in the world. The response patterns of individual species along the disturbance gradient is consistent with ecological theory predicting unimodal peaks in abundance along physical environmental gradients. The ancestral perennial dominants of the grasslands, Dichanthium sericeum and D. queenslandicum, exhibited a declining response to grazing disturbance. Even the generally unpalatable perennial grass Aristida leptopoda declined considerably in the upper segments of the grazing disturbance gradient. A suite of herbaceous trailing legumes had peaks in their abundance near the middle of the grazing disturbance gradient, trends that can be readily explained by the combination of their palatability and intolerance to competition from tall perennial grasses. Several species including the noxious exotic herb Parthenium hysterophorus showed increasing abundance along the grazing disturbance gradient. The methodology may have application as a rapid method of assessing disturbance impacts elsewhere, and is most suited where a management differential between paired plots can be reliably generalized and where the physical environment is relatively monotonous.
Illuminating subcellular structures and dynamics in plants: a fluorescent protein toolbox1

The discovery and development of multicoloured fluorescent proteins has led to the exciting possibility of observing a remarkable array of subcellular structures and dynamics in living cells. This minireview highlights a number of the more common fluorescent protein probes in plants and is a testimonial to the fact that the plant cell has not lagged behind during the live-imaging revolution and is ready for even more in-depth exploration.
phagocytosis of apoptotic leukocytes

Various types of phagocytes mediate the clearance of apoptotic cells. We previously reported that human and murine high endothelial venule (HEV) cells ingest apoptotic cells. In this report, we examined endothelial cell fucoidin re- ceptor-mediated phagocytosis using a murine en- dothelial cell model mHEV. mHEV cell recognition of apoptotic leukocytes was blocked by fucoidin but not by other phagocytic receptor inhibitors such as mannose, fucose, N-acetylglucosamine, phosphatidylserine (PS), or blocking anti-PS re- ceptor antibodies. Thus, the mHEV cells used fu- coidin receptors for recognition and phagocytosis of apoptotic leukocytes. The fucoidin receptor- mediated endothelial cell phagocytosis was specific for apoptotic leukocytes, as necrotic cells were not ingested. This is in contrast to macrophages, which ingest apoptotic and necrotic cells. Endothelial cell phagocytosis of apoptotic cells did not alter viable lymphocyte migration across these endothelial cells. Antibody blocking of CD44 and 4 integrin on the apoptotic leukocyte inhibited this endothe- lial cell phagocytosis, suggesting a novel function for these adhesion molecules in the removal of apoptotic targets. The removal of apoptotic leuko- cytes by endothelial cells may protect the micro- vasculature, thus ensuring that viable lymphocytes can successfully migrate into tissues. J. Leukoc. Biol. 74: 810-820; 2003.
Eurytrema coelomaticum (Digenea, Dicrocoeliidae): the effect of infection on carbohydrate contents of its intermediate snail host, Bradybaena similaris (Gastropoda, Xanthonychidae)

The interface Eurytrema coelomaticum/Bradybaena similaris was studied by quantifying the amount of glucose on the hemolymph and the content of glycogen in the cells of the digestive gland and the cephalopedal mass of infected and uninfected snails. Samples were analyzed on days 0, 30, 90 and 150 post-infection. The infected snails had less glucose in the hemolymph, with a reduction of 67.05 por cento at 30 days, and 62.09 por cento at 90 days post-infection. The reduction in glycogen content was 86.41 por cento in the digestive gland and 79.1 por cento in the cephalopedal mass at 30 days, and 92.71 por cento and 90.89 por cento in these organs respectively at 90 days post-infection. It is proposed that the sporocysts absorb glucose directly from the hemolymph.
Predicting the Outcomes of Single- and Multistage Selections When Applicant Pools Are Small and Heterogeneous

This article presents analytic methods and accompanying computational tools for estimating the expected quality and diversity outcome of general multistage selections when the applicant pool is a finite, typically small sample from a mixture of majority and minority applicant populations. The new methods generalize the analytic estimation of the expected quality of small heterogeneous applicant pool selections from simple, single-stage selection situations to the more general, multistage selection context. In addition, the new methods also compute the sampling variability of the selection quality outcome for these selection decisions.
Review Paper on Spectrum Sharing for 5G Massive MIMO System based on Cognitive Radio Networks

— Cognitive Radio is a promising way to overcome the spectrum scarcity for wireless communication and improving the spectral efficiency by using the vacant licensed spectrum band. Non-Cooperative communication is a new communication technique which utilizes the help of neighboring nodes to reduce the bit error rate (BER) in a harmful fading environment. The challenging factor is to combine the Non-cooperative communication in cognitive radio to improve the spectral efficiency and to reduce the BER factor of unlicensed user’s communication. In this paper, a comparative study of different communication techniques are done by considering Rayleigh fading channel environment and the advantages of non-cooperative communication is analyzed.
A Revision of the Bavayia validiclavis group (Squamata: Gekkota: Diplodactylidae), a Clade of New Caledonian Geckos Exhibiting Microendemism

The genus Bavayiaas currently construed is paraphyletic relative to other New Caledonian diplodactylid geckos. Bavayia validiclavis, from the Massif du Panie in northeastern New Caledonia, is a relatively basal member of the entire New Caledonian diplodactylid radiation and is here recognized as the type species of a new genus characterized by small size and a unique combination of digital and coloration features. Recent surveys of the ultramafic massifs of northwestern New Caledonia have revealed seven additional species assignable to this genus. The new species are morphologically conservative but genetically distinctive from one another. Allopatric apecies occur on the Massif de Koniambo, Mt. Taom, Kaala, the Dome de Tiebaghi and the adjacent Riviere Nehoue, and on the Iles Belep and Ile Yande, off the northern coast of the New Caledonian mainland. Two new species occur sympatrically on Sommet Poum, the northernmost of the mainland ultramafic massifs. Sequence data from the mitochondrial ND2 gene and the nuclear RAG-1 gene yield a single, well-supported phylogenetic hypothesis for the genus and suggest a time of 18.6–19.2 million years to common ancestry. The most recent speciation events in the genus are estimated to have occurred 5.7–10.1 million years ago. Cladogenesis within the genus may be associated with the erosion and fragmentation of ultramafic substrates and/or with climatic and vegetational changes in the region. Because of their very limited distributions, all of the new species are considered to be Endangered or Critically Endangered.
HOW THE COMPETITION OF XANTHIUM STRUMARIUM L. AFFECTS THE PHENOLOGICAL CHARACTERS OF MAIZE CROP

Maize is greatly influenced by competition of Xanthium strumarium L. , having an adverse impact on its phonology and growth. Hence, to evaluate the effect of X. strumarium on phenological characters of maize, field experiments were conducted at the Research Farm of the University of Agriculture Peshawar, Pakistan during summer 2006 and 2007 using a randomized complete block design with split plot arrangement replicated three times. Four maize densities and seven varying densities of X. strumarium were tested. Data were recorded on emergence m -2 , days to tasseling, days to silking, days to maturity, and plant height of maize crop. All the maize phonological characters were significantly affected by the alternate crop and weed densities. The emergence m -2 was significantly reduced with increase in the densities of both the crop and weed. The tasseling stage of maize was delayed significantly at the highest maize density of 12.5 plants m -2 and at the X. strumarium densities ranging from 8 to 12 plants m -2 . The effect on silking stage of maize was significant statistically and it took 4-7 days for the maize plants in all the treatments to switch over from tasseling to silking stage. Weed density of 0 to 4 plants m -2 had a significant effect on days to maturity and the maturity stage was significantly delayed by increasing weed density from 6 to 12 plants m -2 . Plant height of maize was also influenced by the varying densities of either species, and plant heights were greater at 7.5 and 10 maize plants m -2 . Moreover, increasing the X. strumarium density from 0 to 6 plants m -2 , maize plant height progressively increased, however the plant heights declined at 8 to 12 X. strumarium plants m -2 . In light of the results it is concluded that both the crop and weed density do influence the phonological parameters of maize. However, crop density alone is not enough to cope effectively with the higher populations of X. strumarium weed; therefore, multiple cultural approaches should be employed to desirably improve the crop phenology when in competition with this weed.