Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimization of pseudo-Boolean Functions by Stochastic Natural Gradient Descent

Stochastic relaxation is an approach to optimization which a ms at finding the minimum of a function by identifying a proper sequence of probability distri butions, in a given model, that minimize the expected value of the given function. In this paper we pre sent two algorithms, in the stochastic relaxation framework, for the optimization of real-valued functions defined over binary variables: Stochastic Gradient Descent (SGD) and Stochastic Natural G radient Descend (SNDG). These algorithms use an exponential family to sample points from the se arch space and search for the optimum. Due to the properties of the exponential family, both gradie nt and natural gradient can be evaluated in terms of covariances between the function and the sufficie nt statistics of the exponential family. This allows gradient based techniques to be applied in order to find the minimum of the expected value of the function over a set of distributions in a statist ical model. In practice the computation of the exact gradient is unfeasible, but in can be approximated by evaluating empirical covariances.
OTT_A_233338 423..434

Department of General Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, People’s Republic of China Background: Emerging studies have revealed that circular RNAs (circRNAs) correlate with diverse diseases including cancers. However, little is known about the functions of circRNAs in colorectal cancer (CRC). In our previous research, downregulation of hsa_circ_0140388 (circHUEW1) has been detected in CRC tissues through highthroughput sequencing. However, the underlying mechanism by which circHUWE1 regulates the proliferation and apoptosis in CRC has not been investigated. Materials and Methods: The levels of circHUWE1 in 58 pairs of CRC tissues and corresponding adjacent healthy tissues were detected by RT-qPCR. In addition, the effects of circHUWE1 on cell proliferation, apoptosis migration and invasion were evaluated by cell proliferation assays, flow cytometry, and transwell assays in HCT116 and SW480 cell lines respectively. Meanwhile, the dual-luciferase reporter system assay was used to explore the interaction between circHUWE1 and miR-486 (hsa-miR-486-5p). Results: In this study, we demonstrate that the expression of circHUEW1 is upregulated in CRC tissues. High expression of circHUEW1 was significantly associated with lymphovascular invasion (P =0.036), lymph node metastasis (P =0.017), distant metastasis (P =0.024), and TNM stage (P =0.009). Moreover, the area under the curve (AUC) of the receiver operating characteristic (ROC) curve was 0.732, which indicated that circHUWE1 could serve as a potential biomarker in the detection of CRC. Silencing circHUWE1 significantly inhibited the proliferation, migration and invasion capacity of CRC cells in vitro. Mechanistically, we demonstrated that circHUWE1 could sponge miR-486 and the downregulation of miR-486 could reverse the cancer suppressive effects caused by silencing circHUWE1. Conclusion: In this study, our results revealed that circHUWE1 may be a potential therapeutic target and diagnostic biomarker for CRC.
Assessment of Handover Prediction Models in Estimation of Cycle Times for Manual Assembly Tasks in a Human–Robot Collaborative Environment

The accuracy and fluency of a handover task affects the work efficiency of human–robot collaboration. A precise and proactive estimation of handover time points by robots when handing over assembly parts to humans can minimize waiting times and maximize efficiency. This study investigated and compared the cycle time, waiting time, and operators’ subjective preference of a human–robot collaborative assembly task when three handover prediction models were applied: traditional method-time measurement (MTM), Kalman filter, and trigger sensor approaches. The scenarios of a general repetitive assembly task and repetitive assembly under a learning curve were investigated. The results revealed that both the Kalman filter prediction model and the trigger sensor method were superior to the MTM fixed-time model in both scenarios in terms of cycle time and subjective preference. The Kalman filter prediction model could adjust the handover timing according to the operator’s current speed and reduce the waiting time of the robot and operator, thereby improving the subjective preference of the operator. Moreover, the trigger sensor method’s inherent flexibility concerning random single interruptions on the operator’s side earned it the highest scores in the satisfaction assessment.
Modifying ICCA with Trp-Phe-Phe to Enhance in vivo Activity and Form Nano-Medicine

Background 1-(4-isopropylphenyl)-β-carboline-3-carboxylic acid (ICCA) was modified by Trp-Phe-Phe to form 1-(4-isopropylphenyl)-β-carboline-3-carbonyl-Trp-Phe-Phe (ICCA-WFF). Purpose The object of preparing ICCA-WFF was to enhance the in vivo efficacy of ICCA, to explore the possible targeting action, and to visualize the nano-feature. Methods The advantages of ICCA-WFF over ICCA were demonstrated by a series of in vivo assays, such as anti-tumor assay, anti-arterial thrombosis assay, anti-venous thrombosis assay, P-selectin expression assay, and GPIIb/IIIa expression assay. The nano-features of ICCA-WFF were visualized by TEM, SEM and AFM images. The thrombus targeting and tumor-targeting actions were evidenced by FT-MS spectrum analysis. Results The minimal effective dose of ICCA-WFF slowing tumor growth and inhibiting thrombosis was 10-fold lower than that of ICCA. ICCA-WFF, but not ICCA, formed nano-particles capable of safe delivery in blood circulation. In vivo ICCA-WFF, but not ICCA, can target thrombus and tumor. In thrombus and tumor, ICCA-WFF released Trp-Phe-Phe and/or ICCA. Conclusion Modifying ICCA with Trp-Phe-Phe successfully enhanced the anti-tumor activity, improved the anti-thrombotic action, formed nano-particles, targeted tumor tissue and thrombus, and provided an oligopeptide modification strategy for heterocyclic compounds.
N . Abbes Thermodynamic Study of Uranium Extraction from Tunisian Wet Process Phosphoric Acid D

In the present paper, an experimental investigation was conducted to study the thermodynamic of uranium extraction from Tunisian wet phosphoric acid using the synergistic solvent mixture of di-2-ethylhexyl phosphoric acid (DEHPA) and trioctyl phosphine oxid (TOPO) diluted in kerosene. The effect of different factors affecting the extraction process (temperature, TOPO and DEHPA concentrations) has been investigated. The obtained data of temperature effect on the extraction showed that the enthalpy change is -35.8 kJ.mol. The slope analysis method was used for determining the stoichiometry of the extracted species. Keywords—DEHPA-TOPO, extraction, phosphoric acid, stoichiometry, uranium.
Title REVISED ESTIMATES OF THE BIOLOGICAL PARAMETERS FOR ANTARCTIC TOOTHFISH ( DISSOSTICHUS MAWSONI ) IN THE ROSS SEA Author ( s )

This report updates the estimates of the biological parameters for Antarctic toothfish (Dissostichus mawsoni) in the Ross Sea (Subareas 88.1 and SSRUs 88.2A–B). We present revised estimates of the von Bertalanffy growth curves, length weight relationship, and natural mortality based on CCAMLR observer data collected from commercial fishing operations in the Ross Sea. In addition, we review meta-data for plausible estimates of the steepness parameter of the stock-recruitment relationship and recruitment variability of Antarctic toothfish. SUMMARY OF FINDINGS AS RELATED TO NOMINATED AGENDA ITEMS Agenda Item Findings 2.4. 1 We recommend separate age-length keys are used for Antarctic toothfish in the north and slope/shelf areas of the Ross Sea. 2.5. 1 We recommend new von Bertalanffy growth parameters and length-weight parameters for Antarctic toothfish. 2.5. 2 We recommend using a value of M = 0.13 y for Antarctic toothfish. 2.5. 3 We recommend values of σR = 0.60 and h = 0.75 for Antarctic toothfish. This paper is presented for consideration by CCAMLR and may contain unpublished data, analyses, and/or conclusions subject to change. Data in this paper shall not be cited or used for purposes other than the work of the CCAMLR Commission, Scientific Committee or their subsidiary bodies without the permission of the originators and/or owners of the data.
The Examination of Restrained Joints Created in the Process of Multi-Material FFF Additive Manufacturing Technology

The paper is focused on the examination of the internal quality of joints created in a multi-material additive manufacturing process. The main part of the work focuses on experimental production and non-destructive testing of restrained joints of modified PLA (polylactic acid) and ABS (Acrylonitrile butadiene styrene) three-dimensional (3D)-printed on RepRap 3D device that works on the “open source” principle. The article presents the outcomes of a non-destructive materials test in the form of the data from the Laser Amplified Ultrasonography, microscopic observations of the joints area and tensile tests of the specially designed samples. The samples with designed joints were additively manufactured of two materials: Specially blended PLA (Market name—PLA Tough) and conventionally made ABS. The tests are mainly focused on the determination of the quality of material connection in the joints area. Based on the results obtained, the samples made of two materials were compared in the end to establish which produced material joint is stronger and have a lower amount of defects.
The Interdependent Coexistence of the Rational Civilizations: The Mental Origin of Civilizations

The paper purposes that the three major civilizations are territorial rational civilization originated from the tribes before the Axial Age, discrete Western rational civilization originated from the mega empires in Middle East and Greece during the Axial Age, and the connective Eastern rational civilization originated from the mega empires in India and China during the Axial Age. Territorial rational civilization with territorial worldview for ingroup and outgroup individuals produces territorial nationalist democracy based on rule of boundary to deal with ingroup and outgroup individuals. Discrete Western rational civilization with discrete worldview for discrete and independent individuals produces discrete liberty-equality democracy based on rule of law to deal with discrete individuals. Connective Eastern rational civilization with connective worldview for connective and related individuals produces connective common wellbeing democracy based on rule of relation to deal with connective individuals. The current highly international interdependence produces the purposed internationalized interdependent community which allows the interdependent coexistence of the three rational civilizations by establishing the promotion of rational civilizations, the basic rules of relation and law, the potential civilizational and the regional defense boundaries, and the cooperation in international relations. The mental origin of the rational civilization consists of the social brain for instinctive intragroup relations and worldviews to form the original human social group, the mental immune system for instinctive mental therapy, theory of imaginary mind for imaginary religious and political entities with their own minds to form cohesive large social groups, and the thinking brain for rule to form rational civilization.
A Sonochemically-Synthesized Microporous Metal-Organic Framework for the Rapid and Efficient Ultrasonic-Assisted Removal of Mercury (II) Ions in a Water Solution and a Study of the Antibacterial Activity

Nowadays, water pollution due to heavy metal ions is a great concern in all human communities. In this project, a metal-organic frameworks (MOFs), which were named Zn2(oba)2bpy, (1; H2oba = 4,4-oxybisbenzoic acid and bpy = 4,4-bipyridine) linkers, were successfully synthesized. The properties of these MOFs were investigated using different techniques, such as FT-IR, XRD, and SEM analysis. The frameworks have special characteristics, like the rapid, efficient, and selective removal of metal ions from contaminated water. The use of an ultrasonic device plays an important role in shortening the absorption time of mercury (II) ions by increasing absorbent dispersion in the solution. The adsorption capacity was affected by variables such as the pH of the solution, Hg2+ initial concentration, adsorbent dosage, and contact time. For Hg(II) metal ions, the sorption capacity of 338 mgg−1 was effectively obtained by Zn2(oba)2bpy structures. The experimental adsorption data for the Zn2(oba)2bpy MOF is well-suited to the pseudo-second-order kinetic model (R2 = 0.99), and the adsorption isotherms of Hg2+ metal ions are in good agreement with the Langmuir model. This work displays the effective removal of Hg2+ ions from pollutant water in under 30 min. The antibacterial activities of Zn2(oba)2bpy (1) were tested against gram-positive and gram-negative species. The as-synthesized 1 exhibited excellent antibacterial effectiveness against Escherichia coli and Staphylococcus aureus.
SGH_275_2012_10_114 OiK3.indb

Modern enterprises increasingly pursue its development strategy in taking voluntary action for the environment, the local community, the various groups of stakeholders. The measures taken are building a positive image of the enterprise, but also can positively affect the organizational commitment of employees. This article aims to examine whether there is correlation between the level of sustainable development of enterprises and organizational commitment of employees. For this purpose, a survey was conducted among selected enterprises. The results indicate that the initiatives for sustainable development don’t directly translate to the level of organizational commitment. Positive, moderate relationship applies only to affective
Lesion orientation of O4-alkylthymidine influences replication by human DNA polymerase η

Conformation of the α-carbon of O4-alkylthymidine was shown to exert an influence on human DNA polymerase η (hPol η) bypass. Crystal structures of hPol η·DNA·dNTP ternary complexes reveal a unique conformation adopted by O4-methylthymidine, where the nucleobase resides nestled at the active site ceiling where hydrogen-bonding with the incoming nucleotide is prevented.
L-Glutamine Supplementation Improves the Benefits of Combined-Exercise Training on Oral Redox Balance and Inflammatory Status in Elderly Individuals

Although regular combined aerobic-resistance exercises can ameliorate the inflammatory status and redox balance in elderly population, it is unclear whether protein or specific amino acid supplementation could improve such benefits. Therefore, we aimed to evaluate the inflammatory status and redox indexes through of the saliva of 34 elderly subject nonpractitioners (NP group, 73.3 ± 6.6 years) and 49 elderly subject practitioners of a combined-exercise training in moderate intensity (CET group, 71.9 ± 5.8 years) before (pre) and after (post) 30 days of supplementation with L-glutamine (Gln) or placebo (PL). Our results showed that, both in pre- and postsupplementation, the salivary levels of nitric oxide (NO·) and TNF-α were lower, whereas the levels of uric acid and IL-10 (as well as IL-10/TNF-α ratio) were higher in the CET groups than in the NP groups. In postsupplementation, both groups supplemented with Gln (NP-Gln and CET-Gln) showed higher salivary uric acid levels compared to baseline. In addition, lower NO· levels were found in the CET-Gln group postsupplementation than presupplementation values. Whereas the CET-Gln group showed lower GSH levels postsupplementation, NP-Gln subjects showed lower GSSG levels at the same time point, both compared to baseline. Interestingly, salivary peroxidase activity was lower only in NP groups (NP-PL and NP-Gln) postsupplementation than baseline values. A positive significant correlation between salivary peroxidase activity and GSH levels, and also between salivary peroxidase activity and uric acid levels were observed in the CET-Gln group both pre- and postsupplementation. No differences were found in albumin, total antioxidant activity (TEAC), and reducing power analysis between groups, pre- or postsupplementation. In conclusion, the elderly subjects from the CET group showed a better inflammatory response and redox balance and, for the first time, it was shown that daily supplementation with Gln for 30 days can improve these benefits with putative association with a healthy aging.
Rapid and comprehensive indicator for evaluation of performance of treatment processes and of river waters

Naturally occurring UV active compounds, commonly present in almost all source waters, can be rapidly monitored by their ultraviolet absorbance at 260 nm (E260). Herein, the extent of correlation between the E260 and the removal efficiency of the hazardous contaminants, endocrine disrupters and dioxins, were investigated using various treatment and river source waters. The detection of various types of hazardous contaminants using sophisticated analytical methods, such as high resolution gas chromatography (HRGC)/high resolution mass spectrometry (HRMS) and high performance liquid chromatography (HPLC)/inductively coupled plasma (ICP)/mass spectrometry (MS), as well as various short-term bioassays, can require hours or even days for results to be obtained. The removal of the E260 correlated well with those of individual contaminants, such as endocrine disruptor chemicals and dioxins, with the various treatment processes employed. In the plots of the endocrine disrupters against the DOC/E260, a correlation was found with the endocrine activity of the Korean/Japanese river waters employed in this study.
Automated Table Understanding using Stub Patterns Analysis

Tables are a widely-used structure for data presentation and summarisation in documents from many different domains. However, most of tables are designed for human readers and their layout and logical structure are not well defined for machine processing. As a result, the tasks of extracting data from tables are not yet fully automated, and existing solutions tend to focus on a domain or application, relying on external knowledge sources. Considering the diversities of tables in their topological structure, finding an automated solution that works for all different tables is difficult. In this paper, we identify some of the common features in the logical structures of tables by analysing the header arrangement patterns as a step towards building an automatic processing technique. This allows us to describe a set of table understanding rules and heuristics in an unambiguous way. Based on the patterns, we have developed our own table understanding system. We report on its performance on well-known datasets.
Differential Expression of Genes in Response to Temperature Conditions Selected by Transcriptome Analysis of Grapevine Leaves

Temperatures worldwide have been rising due to global warming. The Korean grapevine (Vitis labruscana) cultivars are sensitive to high temperature during the vegetative growing period and are challenged with various physiological disorders, resulting in decreased production and poor quality of fruit. This study was conducted to identify genes that are differentially expressed in response to high temperature to help elucidate the mechanism of tolerance to temperatures in grapevines. ‘Kyoho’ grapevine leaves were maintained at 25°C and 35°C for 24 h in a plastic house and then used for transcriptome analysis by RNA-seq. More than 92 million transcripts were used for transcriptome analysis, with a total length of 7 billion bp and an average length of 89.6 bp; an average of 85.5% of the data were used in the final analysis. Investigation of differentially expressed genes (DEG) in response to high temperature discovered 243 induced genes and 378 inhibited genes. The selected DEGs were related to metabolism (49 genes), cell structure (22 genes), and molecular functions (15 genes). The selected DEGs clustered in the pathways of carbohydrate metabolism, amino acid metabolism, and the citrate cycle in the KEGG metabolic pathway. Among the selected DEGs, we selected the top 10 highly up-regulated and the top 10 down-regulated genes and confirmed their expression levels by reverse transcription quantitative PCR. At high temperature, the top 10 genes, including BCL-2-associated athanogene 6, heat shock protein 21, HAD superfamily, and subfamily IIIB acid phosphatase, showed induced expression, whereas the other 10 genes, including APS reductase3, ribosomal protein S7e family protein, and ribosomal protein L2 family, showed inhibited expression pattern. This is consistent with the results from the transcriptome analysis. We propose that these genes can potentially be used for the development of molecular markers to elucidate defense mechanisms against high temperature stress, and for breeding grapevine varieties tolerant to high temperature. Additional key words: defense mechanism, physiological disorder, RNA-Seq. , tolerance, viticulture
Estimation Method for Radiation Resistance of Multi-junction Solar Cells using I-V Characteristics of Subcells

The radiation degradation characteristic of a multi-junction (MJ) solar cell is more complicated compared to a single-junction (1J) solar cell. To perform the quantitative radiation resistance evaluation of a MJ solar cell, it is necessary to estimate the parameter of subcells in the MJ solar cell, such as the reverse saturation current density (J0), photo current (Iphoto) and shunt resistance (Rsh). In this work, the technique used to estimate each parameter (J0, Iphoto, Rsh) of each of the subcells in the MJ solar cell is suggested by combining the electroluminescence (EL) method, which proposed by Fraunhofer group, and the LED bias light (LBL) method. Furthermore, the decline in the maximum power (Pmax) of the MJ solar cell was predicted on the circuit simulator using this technique before and after 1 MeV electron irradiation.
CEOR_A_222879 683..694

1Pharmacy Department, Clínico San Carlos Hospital, Madrid, Spain; 2Pharmacy Department, University De Getafe Hospital, Madrid, Spain; 3Hematology Department, Clinic Hospital, Barcelona, Spain; 4Health Economics and Outcome Research, Novartis Farmacéutica S.A. , Madrid, Spain; 5Pharmacy Department, University Hospital Araba, Vitoria, Spain; 6Oblikue Consulting, S.L. , Barcelona, Spain; 7Hematology Department, University Hospital 12 de Octubre, CNIO, Complutense University, Madrid, Spain; 8Hematology Department, University Hospital La Fe, Valencia, & CIBERONC, Instituto Carlos III, Madrid, Spain; 9Hematology Department, University Hospital Santa Creu i Sant Pau, Barcelona, Spain; 10Pharmacy Department, Sant Joan de Déu Hospital, Barcelona, Spain Purpose: The addition of midostaurin to standard chemotherapy (cytarabine and daunor-
Structure, magnetic and cytotoxic behaviour of solvothermally grown Fe3O4@Au core-shell nanoparticles

Magnetic nanoparticles (MNPs) have demonstrated their potential in a wide variety of biomedical applications including in tumour hyperthermia. However, highly reactive nature and aggregation affinity of these nanostructures are the principal limitations for such applications. To overcome these limitations, those MNPs should be covered with an inert shell in order to protect the magnetic core against chemical alterations. Considering the noble, chemically inert nature of gold, which also has good biocompatibility, we fabricated chemically stable gold-coated Fe3O4 (Fe3O4@Au) nanoparticles of 20–50 nm size range with considerable saturation magnetization, though a simple one-pot solvothermal method. The morphology, elemental distribution and the structure of the core-shell nanoparticles were characterized using aberration-corrected (Cs) Scanning transmission electron microscopy (STEM), and compared with their simulated images. Cytotoxicity assay in MDCK cell line was performed to evaluate the biocompatibility of the nanoparticles. The results showed higher cell viability for the Fe3O4@Au nanoparticles, suggesting their good biocompatibility and potentials for biomedical applications.