Miracle-dz/UniFAR-FTUs huggingface dataset:
Transmucosal in addition to transdermal fentanyl, administered in exacerbations of cancer pain, does not change the emotional status of patients

__________________________________________________________________________________________ Introduction: Opioids, regardless of the route of administration, are essential analgesics for the treatment of cancer pain. The transmucosal route of fentanyl administration is a relatively new but widely used technique. Purpose: The authors attempted to assess the effectiveness of a submucosal dose of fentanyl, indicated for the control of breakthrough pain in patients who are on the transdermal fentanyl patch, and to evaluate the impact of both opioids on the emotional state of the patient. Materials and methods: 48 patients were assigned to different analgesia groups, and the VAS pain scale and Beck Depression Inventory, before and after submucosal analgesia, were used to evaluate their pain. Results: It has been shown that fentanyl provides dose-dependent analgesia. This analgesia is independent of the concentration of fentanyl in the blood serum. The method of administration of fentanyl has no effect on the level of depression, according to the BDI inventory. Furthermore, there is no statistically significant effect on the mood of the patient group based on the analgesia used. Conclusions: Submucosal fentanyl added to the basic analgesic therapy is effective, well tolerated, and does not alter patient mood.
Polymorphisms of the TAP2 Genes in Chinese Patients with Systemic Lupus Erythematosus in Taiwan

Objective: The purpose of this study was to determine how polymorphisms of transporter associated with antigen processing 2 (TAP2) alleles contribute to the pathogenesis of systemic lupus erythematosus (SLE) in Taiwan. Methods: We enrolled 84 patients with SLE and 105 healthy controls. The polymorphisms were detected by polymerase chain reaction (PCR)-based restriction analysis. The relationships between SLE and TAP2 polymorphisms were evaluated. Results: No significant differences were found between normal subjects and SLE in TAP2-1 (p=0.28), TAP2-2 (p=0.55) and TAP2-3 (p=0.52) polymorphisms. However, the G allele of TAP2-1 was significantly more common than the A allele in cutaneous manifestations of SLE patients (malar rash, χ^2=6.90, p=0.001; discoid rash, χ^2=5.10, p=0.02; and photosensitivity, χ^2=5.80, p=0.02). Similarly, The G allele of TAP2-1 had a statistic significance than A allele in positive ANA of SLE patients (χ^2=9.35, p=0.002). Conclusion: Our data indicate that TAP2-1, TAP2-2 and TAP2-3 polymorphisms are not candidate genetic markers of SLE. However, the G allele of TAP2-1 may serve as a marker for cutaneous manifestations (malar rash, discoid rash and photosensitivity) and positive ANA in SLE patients.
Nano-hydroxyapatite/chitosan sponge-like biocomposite for repairing of rat calvarial critical-sized bone defect

A three-dimensional porous nano-hydroxyapatite (nHA)/chitosan (CS) biocomposite was synthesized. The rod-like nHA grains of 15–30 5–10 nm in size were observed by TEM and confirmed by characteristic XRD patterns. The diameters of the interconnecting pores of the nHA/CS biocomposite, determined by SEM, were 120–300mm. Standard critical-sized calvarial bone defect (Ø1⁄4 6.5 mm) was created in Sprague-Dawley (SD) rats. In group 1, nHA/CS was implanted and in group 2, no implant was made in the defect. After 1 week, the histological assessment of group 1 clearly showed that a large number of living cells were anchored in the pores of the nHA/CS implants. New bone formation, both at the edge and in the center of implants, was found as early as 2 weeks. Histological assays confirmed that the newly formed bone tissue was bioactive and neovascularized. After 5 weeks, the mineral content and volume of the newly formed bone tissue in the defects were significantly greater in group 1 than in group 2 (p< 0.01). These results indicate that implantation of the nHA/CS enhanced the repair of bone defect and confirm the potential of this biocomposite as a bioactive bone grafting substitute.
Psychotropic medications and breastfeeding

World health experts encourage women to breastfeed, but many primary care physicians, obstetricians, and psychiatrists are hesitant to encourage new mothers who are taking psychiatric medications to do so. Unfortunately, there are only a few casecontrolled studies on the safety of psychotropics in breastfeeding. This article outlines the benefits of breastfeeding, both for the infant and for the mother; postpartum illness and its effect on the mother and infant; and the existing data on the most commonly used psychotropics. The effect of psychotropics on the nursing infant is examined and summarized.
Efficacy and safety of topical mometasone furoate 0.01% vs. tacrolimus 0.03% and mometasone furoate 0.01%in vitiligo

Objectives To compare the efficacy and safety of topicalmometasone furoate 0.01% vs. tacrolimus 0.03% and mometasone furoate 0.01% in vitiligo. Patients and methods This interventional, quasi-experimental study was conducted at Department of Dermatology, Lady Reading Hospital, Peshawar, from January, 2008 to August, 2008. Patients were selected by non-probability purposive sampling method after obtaining an informed consent. Sixty patients of vitiligo (26 male and 34 female), aged older than five years and involving less than 30% of body surface area were enrolled. All the patients were randomly divided into two equal groups using random number table. Group I patients were treated with twice daily application of topical mometasone furoate 0.01%, whereas those of group II were advised to apply mometasone plus tacrolimus ointment on the lesions twice daily. The patients were followed up weekly for first month and later on fortnightly for five months to monitor the improvement and adverse effects. Results Tacrolimus plus mometasone was effective (grade 4-5) in 70% of patients whereas topical mometasone alone was effective (grade 4-5) in none of the patients. The results of combination therapy were much better than mometasone alone. The combination therapy was also more effective in type Π and type Ш skin than type IV skin. No side effects were observed in two groups. Conclusion We recommend that topical mometasone has no role in the treatment of vitiligo in type IV skin but when combined with tacrolimus may potentiate its efficacy.
Unusual Case of Necrotizing Pneumonia

Coccidioidomycosis is caused by inhalation of Coccidoides spores which is endemic in south western parts of USA and an uncommon cause of pneumonia in non-endemic areas. We report a young Hispanic man who lives in New York presenting with diabetic ketoacidosis and severe pulmonary Coccidioidomycosis. Through this case report and review we want to familiarize clinicians from non-endemic area to this unusual cause for necrotizing pneumonia, its association with diabetes mellitus, other risk factors for dissemination and the management strategy.
Veritas Annotator: Discovering the Origin of a Rumour

Defined as the intentional or unintentionalspread of false information (K et al., 2019)through context and/or content manipulation,fake news has become one of the most seriousproblems associated with online information(Waldrop, 2017). Consequently, it comes asno surprise that Fake News Detection hasbecome one of the major foci of variousfields of machine learning and while machinelearning models have allowed individualsand companies to automate decision-basedprocesses that were once thought to be onlydoable by humans, it is no secret that thereal-life applications of such models are notviable without the existence of an adequatetraining dataset. In this paper we describethe Veritas Annotator, a web application formanually identifying the origin of a rumour.These rumours, often referred as claims,were previously checked for validity byFact-Checking Agencies.
The Knowledge Measurement Model Provided to the ASEAN Economic Community

The purposes of this research aim to analyze the proficiency knowledge preparation step readiness for the member country of ASEAN Economic Community and to determine the questions quality for the knowledge level preparation readiness for the member country of ASEAN Economic Community. The 400 samples were the residents whose residential in the area of Kanjanaburi, Suphanburi , Nakhonpathom and Ratchaburi. The exploratory factor analysis was performed with rotation the scene by Varimax method. The statistical program was used to confirm the factor analysis of the Knowledge Measurement provided to the ASEAN Economic Community. The results showed that the knowledge elements in preparation for the ASEAN Economic Community compose of 10 factors which each element loading factors ranged between 0.11 to 2.45 The quality of the model test results with empirical data found that chi square score indicated at 36.94, the probability score indicated at 0.12, the degrees of freedom score indicated at 28, the adjusted score indicated at 0.96, the root of mean square error of approximation indicated at 0.028.
OBJECT MODEL EXTRACTION USING SEMANTIC CHUNK-BASED APPROACH

Chunk-based object model extraction is one of the attempts to bring the meaningful information from the natural language sentences. In recent years, the number of problem for information overload has been increasing and most of researchers have taken into account the automatic information extraction using the availability of semantics based models (e.g, ontologies and taxonomies). Semantics based models have been widely used in integration of discovered knowledge with information extraction process to provide the meaningful concepts and information. This paper proposes an efficient technique called chunk-based information extraction approach which relies on ontology and an extraction of object attributes from the natural language text using chunks in sentences. To recognize the object attributes, an established chunk-based recognition from the sentences and extraction of object attributes using ontology is integrated into the information extraction process. We propose to test our approach in the customer requests of the rental service with respect to the potential effect of information about the relationship of customers and product items. This technique can be efficient in extraction of information from free text sentences to be automatic and save energy and time for human beings with the effective user interface.
Design low power SRAM using MTCMOS Technique with Nanometer Regime

In this paper proposed to new high performance SRAM Cell with the help of MTCMOS Techniques. This paper represents the simulation of 6T SRAM cells using low power reduction techniques and their comparative analysis on different parameters such as Power Supply Voltage, Delay, Operating Temperature and the leakage power , leakage current and active power. In comparison to the conventional 6T SRAM bit-cell, the total leakage power is reduced. In all simulation have been carried out “Empyrean Aether” tool using 180 nm technologies. Keywords—read stability, write stability, MT CMOS techniques, SRAM and VLSI.
UNIFORMLY BOUNDED COMPOSITION OPERATORS IN THE SPACES OF FUNCTIONS OF TWO VARIABLES OF BOUNDED φ-VARIATION IN THE SENSE OF RIESZ

In this paper we prove that if a uniformly bounded the nonlinear composition operator maps a subset of the space of functions of bounded total φ-bidimensional variation with weight function in the sense of Riesz, into another space of that type (with the same weight function), then the generator function of the operator is an affine function in the third variable. This extends previous results (see [1, 5, 9, 10]) in the one and two-dimensional setting.
A NOVEL APPROACH FOR DENOISING ELECTROCARDIOGRAM SIGNAL USING HYBRID TECHNIQUE

One of the core concerns in the area of Biomedical Signal Processing has been the extraction of pure cardiologic indices from noisy measurements. Frequently, it is found that treatment of the patient suffers due to improper information of Electrocardiogram (ECG) signal since it is highly prone to the disturbances such as noise contamination, artifacts and other signals interference. Therefore, an ECG signal must be denoised so that the misrepresentations can be eliminated from the original signal for the perfect diagnosing of the condition and performance of the heart. In this paper, hybrid techniques including combination of Median filter, Savitzky-Golay filter and Extended Kalman filter along with Discrete Wavelet Transform have been focussed for separation of noise from ECG signal. The hybrid methods for obtaining a clean ECG signal are designed and implemented in MATLAB environment by utilizing MIT-BIH Arrhythmia database. Performance of different algorithms is compared on the basis of signal to noise ratio (SNR) and mean square error (MSE) and it has been noticed that Extended Kalman filter followed by Discrete Wavelet Transform provides better results for both the parameters.
Growth Through Inter-sectoral Knowledge Linkages

The majority of innovations are developed by multi-sector firms. The knowledge needed to invent new products is more easily adapted from some sectors than from others. We study this network of knowledge linkages between sectors and its impact on firm innovation and aggregate growth. We first document a set of sectoral-level and firm-level observations on knowledge applicability and firms’ multi-sector patenting behavior. We then develop a general equilibrium model of firm innovation in which inter-sectoral knowledge linkages determine the set of sectors a firm chooses to innovate in and how much R&D to invest in each sector. It captures how firms evolve in the technology space, accounts for cross-sector differences in R&D intensity, and describes an aggregate model of technological change. The model matches new observations as demonstrated by simulation. It also yields new insights regarding the mechanism through which sectoral fixed costs of R&D affect growth.
Bacteria Biotope Relation Extraction via Lexical Chains and Dependency Graphs

abstract In this article, we describe our approach for the Bacteria Biotopes relation extraction (BB-rel) subtask in the BioNLP Shared Task 2019. This task aims to promote the development of text mining systems that extract relationships between Microorganism, Habitat and Phenotype entities. In this paper, we propose a novel approach for dependency graph construction based on lexical chains, so one dependency graph can represent one or multiple sentences. After that, we propose a neural network model which consists of the bidirectional long short-term memories and an attention graph convolution neural network to learn relation extraction features from the graph. Our approach is able to extract both intra- and inter-sentence relations, and meanwhile utilize syntax information. The results show that our approach achieved the best F1 (66.3%) in the official evaluation participated by 7 teams.
Analysing the Slabs by Means of the Finite Difference Method

Slabs rank among structures which are used very frequently. The slabs can be analysed by the finite difference method which is described in this paper. Two types of square concrete slabs are used for the analysis. Deflections, specific bending moments and torsion moments were chosen for the analysis. Algorithms for the calculation were developed and calculated for various systems of equations. This paper also aims at evaluating time which each method needs for solution of a set of linear equations with algorithms developed in Matlab. Results of this method are compared with those obtained by the finite element method. Key-Words: Finite element method, finite difference method, slab, algorithms, speed calculation, deflection
Validation Study of Colombia’s ECAES English Exam

In 2005, Colombia’s Ministry of National Education developed a nationwide program to improve the teaching and learning of English. As one of this project’s initial steps, the Ministry developed two English tests included in the Common European Framework of Reference (CEFR). This paper presents the findings from a study that examined the validity of one of these tests, the ECAES English Exam. Data for this study was gathered using content evaluation sessions with teachers and think-aloud protocols with students. Our findings suggest that this test may not be a valid measure of the students’ general English language proficiency.
Changes in body composition of senior females induced by strength-endurance motor program

The aim of work was to determine the effects of 8-week strength-endurance training program on somatic indicators in senior females. Applying bioelectrical impedance analysis method (InBODY 230 device) we evaluated the following parameters: body weight, BMI, body fat, total skeletal muscle mass, body fat percentage, skeletal muscle mass in left and right upper and lower extremities, trunk muscle mass, and the mineral mass in the body. To assess regularity of physical activities, variability of lifestyle and quality of life, we used a standardized survey questionnaire. The study was carried out on 29 senior citizens, of the average 70.28 years of age and BMI 26.47 kg/m2. A group of active elderly women underwent an 8-week strength-endurance program, including exercises focused primarily on the development of strength abilities of the upper limbs, and secondarily on developing strength abilities of lower extremities and developing general aerobic abilities. The influence of the aerobic program induced statistically significant increase in the total skeletal muscle mass from the initial value of 22.966 kg to 23.552 kg, an increase by 0.552kg (p ≤ 0.01) of the monitored parameter. On the contrary, the parameter of body fat percentage of the studied group showed significant decrease of the input value of 36.207%, to the output value of 35.062%, representing a change at the level of 1.145% (p ≤ 0.01). By assessment of changes in the muscle mass of upper limbs and the trunk, we found a statistically significant increase, which reflects a change in the total quantity of the skeletal muscle (p ≤ 0.005). The mineral mass in the probands increased by only 0.091 kg. However, this increase was confirmed at 0.1% level of statistical significance (p ≤ 0.001). The above results indicate that regular performance of physical activities in groups of the elderly proves to be efficient in preventing sarcopenia, obesity and maintaining a balance of the particular tissues making up the total body composition.
Development, Characterization and Antidiabetic Potentials of Nilgirianthusciliatus Nees Derived Nanoparticles

Nilgirianthus ciliatus Nees is used in traditional Indian system of medicine for the treatment of numerous physiological disorders. Previous investigations revealed that various bioactive compounds have been isolated from this plant for the treatment of various disorders. But these compounds may be unstable in gastrointestinal tract due to the elevated pH and harsh condition that renders the bioactive compounds ineffective. In order to improve the pharmacokinetic and pharmacodynamic properties of various drugs, nanoparticles were developed by various techniques. Nanoformulation of ethanolic extract of Nilgirianthus ciliatus was prepared by solvent evaporation technique using gelatin as carriers and evaluated its antidiabetic effects in L6 myoblasts and 3T3L1 adipocytes. The mean particle size of plant extract loaded gelatin nanoparticles was approximately 110 nm and they are spherical in shape on observation by transmission electron microscope. The ethanolic extract of Nilgirianthus ciliatus was encapsulated with 80% efficiency in gelatin biodegradable nanoparticles formulation. MTT assay was also performed to study the toxicity of nanoformulation; the nanoencapsulated form does not produce any toxicity upto 1000 μg/ml concentrations. Nanoformulation of Nilgirianthus ciliatus was evaluated for its antidiabetic activity by glucose uptake assay in L6 cells and anti-adipogenic assay in 3T3L1 preadipocytes. The plant extracts loaded nanoparticles showed significant antidiabetic effect in both assays in a dose dependent manner when compared to the ethanolic extract. After nanoencapsulation the aqueous dispersion is more, this may be the reason for the better antidiabetic effect. Therefore nanoencapsulated Nilgirianthus ciliatus could be considered as potential antidiabetic drug.
Quantitative Measurement of Symmetry from Photographs following Surgery for Unilateral Cleft Lip and Palate

A computer-based program is presented to be used with digitized frontal and basal photographs. SymNose enables the user to quantify asymmetry of the front view of the lip and nose and of the nose from the base view, using the area of mismatch of one side reflected over the other. There is a facility to transfer results to a spreadsheet. The program is simple and quick to use and runs on Apple Macintosh OSX 10.4 or later, power and Intel-based systems. The outline of a feature can be drawn using the mouse or digitizing pad. The program, together with Help files, is available from the authors.
Patient safety and quality of care: How may clinical simulation contribute?

The usability of health information technology (IT) is increasingly recognized as critically important to the development of systems that ensure patient safety and quality of care. The substantial complexity of organizations, work practice and physical environments within the healthcare sector influences the development and application of health IT. When health IT is introduced in local clinical work practices, potential patient safety hazards and insufficient support of work practices need to be examined. Qualitative methods, such as clinical simulation, may be used to evaluate new technology in correlation with the clinical context and to study the interaction between users, technology and work practice. Compared with the “classic” methods, such as heuristic inspection and usability testing, clinical simulation takes the clinical context into account. Clinical simulation can be useful in many processes in the human-centred design cycle. In the requirement specification, clinical simulation can be useful to analyze user requirements and work practice as well to evaluate requirements. In the design of health IT, clinical simulation can be used to evaluate clinical information systems and serve as common ground to help to achieve a shared understanding between various communities of practice. In a public procurement process, a clinical simulation-based assessment can help give insight into different solutions and how they support work practice. Before organizational implementation, clinical simulation is a very suitable means, by which to assess an application in connection with work practice. https://doi.org/10.34105/j.kmel. 2015.07. 027
Radioimmunoassay of Atrial NatnureticPolypeptidein Heat-TreatedHumanPlasma

interference is minimized by deproteinizingthe plasma by heat treatment at 85 #{176}C for 10 mm. We directlymeasure ahANP in the supernatesby AlA, with use of antiserumthat recognizesthe N-terminal region of a-hANP. The minimal detectablevalue was 0.4 pg per tube. The intra-assayCV was 6.6% (n = 8). The mean concentrationof hANP in plasma of 54 healthy volunteers was 41 (SD 29) ng/L. Concentrationsof hANP in plasma increased after saline infusionand high salt intake for one week in patientswith essentialhypertension.High concentrationswere also measured in patients with renal failure and congestive heart failure.This method,whichrequiresno extractionor purification with column chromatography,is especially useful for simultaneousmeasurementof several samples. AdditionalKeyphrases:hypertension renal failure heart disease . sample treatment with chromatographiccartridges compared RIA of hANP in plasma has been widely used to investigate the physiological and pathophysiological roles of newly discovered a-hANP (J). 3 To determine the concentrations of a-hANP in plasma, several investigators (2-4) have used a purification method involving Sep-Pak C18cartridges. However, this extraction method is very complicated and time