Miracle-dz/UniFAR-FTUs huggingface dataset:
Quantitative Platial Analysis: Methods for Handling and Representing Platial Heterogeneity and Linking Varying Concepts of Place

This paper explores potential approaches for quantitative platial analysis. It revisits some of the early work examining place in social media data in light of recent proposals for a platial GIS. Focussing on Massey’s concept of space that incorporates a sense of belonging and kinship, where space becomes place through social relations, it uses coded Twitter data containing the term “shithole” to generate a predictive models of diﬀerent types of platial denigration. These are used to infer the spatial distribution of diﬀerent types of platial denigration. The results show that there is little spatial pattern to denigration of diﬀerent places and sports facilities, but that denigration of one’s own local area and of one’s own personal space have highly localized distributions. The discussion indicates a number of areas for further research with a particular warning against developing platial GISs as has been suggested by many authors. Other explicitly GIScience avenues may be more productive and insightful. relations with that place. There is a strong nostalgic element to this concept of place, and for Massey impersonal, symbolically distant “space” becomes “place” when social relations and memories are interwoven with physical space. Thus place-making is ongoing and relates to belonging. A place is known and intimate and depends on the imposition of bodies and relations between those bodies in order to exist as anything other than space. Massey’s formulation of space and place oﬀer to this study an understanding that foregrounds the process of place: place is ongoing and continually shaped. of
Co-expression of the Type 2 Diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the adenosine-5’-triphosphate and sulfonylurea sensitivities of the ATP-sensitive potassium channel

This is an uncopyedited electronic version of an article accepted for publication in Diabetes. The American Diabetes Association, publisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version will be available in a future issue of Diabetes in print and online at http://diabetes.diabetesjournals. org. Diabetes Publish Ahead of Print, published online July 8, 2009
CMAR_A_267927 11883..11895

1Department of Urology, Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang Province, People’s Republic of China; 2Department of Surgery, The Third People’s Hospital of Hangzhou, Hangzhou, Zhejiang Province, People’s Republic of China Background: Emerging evidence indicates that circular RNAs (circRNAs), which form as covalently closed loops, play a regulatory role in various types of cancer, including prostate cancer (PCa). CircSLC19A1, one kind of circRNA, was subjected to the study and its role in PCa was explored. Methods: Expressions of circSLC19A1, miR-326 and MAPK1 in PCa tissues and cells were assessed by qRT-PCR. CircSLC19A1 was identified by RNase R treatment. The binding relations between circSLC19A1 and miR-326 and between miR-326 and MAPK1 were predicted by RegRNA2.0 or Targetscan7.2 and further confirmed by dual-luciferase reporter assay. Pearson correlation analysis of the correlation among circSLC19A1, miR-326 and MAPK1 was performed. CCK-8, cell colony formation, wound healing and Transwell assays were used to assess PCa cell viability, proliferation, migration and invasion, respectively. Results: CircSLC19A1 expression was up-regulated in PCa tissue and cell cytoplasm. Silencing circSLC19A1 inhibited PCa cell viability, proliferation, migration, invasion and miR-326 expression. MiR-326 inhibitor promoted the luciferase activities of circSLC19A1 and MAPK1, increased MAPK1 expression and facilitated PCa cell progression. MiR-326 expression was down-regulated in PCa tissue and there was a negative correlation between miR-326 and circSLC19A1 expressions. MAPK1 expression was up-regulated in PCa tissue. There was a negative correlation between MAPK1 and miR-326 expressions as well as a positive correlation between MAPK1 and circSLC19A1 expressions. Silencing MAPK1 promoted the viability, proliferation, migration, and invasion of PCa cells co-transfected with siRNA-circSLC19A1a and miR-326 inhibitor. Conclusion: CircSLC19A1 silencing inhibited PCa cell proliferation, migration and invasion through regulating miR-326/MAPK1 axis.
GOLD NANOPRATICLES IN SCIENCE, TECHNOLOGY AND HEALTH CARE: A REVIEW

The gold colloid is a solution of colloidal nanoparticles in gold in its liquid state. These particles are usually red in color. Due to their versatile properties in the field of optics, electronics, and molecular recognition, they are subjected to immense research. They are a preferred choice in technologies like electron microscopy, electronics, nanotechnology, material sciences, and health care. In many different types of colloidal gold synthesis, the combination of gold nanoparticles with certain ligands can increase its potent and usage in different fields. They are capable of delivering useful drugs in difficult areas like the brain, retina, tumors, and intracellular organelles. However, their efficiency highly depends on their size and shape. They are also under study as carriers for serious drugs like Paclitaxel. Gold nanoparticles are also used in drugs used for the treatment of cancer. However, if consumed in unprescribed amounts have proved to be toxic to the body. Different sizes of gold particles have shown buildup in parts of the brain, stomach, pancreas, kidneys, liver and blood. Gold nanorods have A layer of Au solution by using the seed-mediated method on the NPs. Other trials showcased the attachment process of nanospheres to the core made of silica of Amino terminated was used until the seed into one of the shell by the reduction of Au The diameter of the silica could help calculate the diameter of the Au nanoshells.
BFJ-02-2021-0198_proof 362..383

Purpose – Chinese beer consumption has undergone major changes within the last decade. The combination of a growingmiddle class and greater exposure to foreign products has resulted in a significant increase in beer imports. The authors examined transformations in this market and how beer preferences have changed over time. This study focuses on changes is origin-specific preferences (e.g. German beer and Mexican beer) as reflected by habit formation (i.e. dynamic consumption patterns) and changes in demand sensitivity to expenditure and prices. Design/methodology/approach –The authors estimated Chinese beer demand – differentiated by source – using a generalized dynamic demand model that accounted for habit formation and trends, as well as the immediate and long-run effects of expenditures and prices on demand. The authors employed a rolling regression procedure that allowed for model estimates to vary with time. Preference changes were inferred from the changing demand estimates, with a particular focus on changes in habit formation, expenditure allocating behaviour, and own-price responsiveness. Findings – Results suggest that Chinese beer preferences have changed significantly over the last decade, increasing for Mexican beer, Dutch beer and Belgian beer. German beer once dominated the Chinese market. However, all indicators suggest that German beer preferences are declining. Originality/value – Although China is the world’s third largest beer importing country behind the United States and France. Few studies have focused on this market. While dynamic analyses of alcoholic beverage demand are not new, this is the first study to examine the dynamics of imported beer preferences in China and implications for exporting countries.
Energy expenditure and net substrate utilization in men ingesting usual and high amounts of nonstarch polysaccharide 1–3

Background: Diets intrinsically high in nonstarch polysaccharides (NSPs) are frequently advised for body weight regulation and health, but the consequences for energy expenditure and fuel selection are undetermined. Objective: We determined whether energy expenditure and fuel selection differ when men consume a diet intrinsically higher in NSP than a usual mixed diet. Design: A randomized crossover design was used in which 12 healthy men were fed a maintenance diet for (cid:60) 3 wk in a metabolic suite. By judicial choice of food exchanges, the usual- and high-NSP diets were similar in protein, fat, and carbohydrate contents. Twenty-four–hour, indirect, open-circuit calorimetry was per-formed, including measurements of total hydrogen gas and methane. Participants were weight stable (within 2 kg for 3 wk), entered an 11-m 3 calorimetry chamber for 36 h with measurements taken in the last 24 h, and underwent a strictly controlled program of moderate physical activity (1.3 (cid:51) basal metabolic rate). Results: The mean total 24-h energy expenditure and percentages from protein, fat, and carbohydrate metabolism were 10 MJ/d and 16%, 35%, and 48%, respectively. Differences (mean – SEM) between the 2 diets were only (cid:50) 0.005 – 0.130 MJ/d, (cid:50) 0.3 – 1.3%, (cid:50) 0.2 – 2.0%, and 0.6 – 2.2%, respectively, and were nonsignificant ( P > 0.2). Conclusions: There was no thermogenic response to the high-NSP diet, which would be advantageous for body weight control, and no short-term influence on body composition, as may be judged from a lack of change in protein, fat, or carbohydrate metabolism. 1998;68:820–6.
The Effect of Emotional Competencies on Team Functioning The Effect of Emotional Competencies on Team Functioning

Borders, R. 2019. The Effect of Emotional Competencies on Team Functioning. Collaboration, cohesion, and trust within teams can lead to beneficial outcomes such as innovation, speed of innovation delivery, enhanced creativity, and improved performance. Because of the prevalence of teams in the workforce, it is important that teams function at their highest capacity. One way to enhance team functioning may be to improve emotional intelligence (EI) in team members. Research has shown that higher EI is related to individual benefits such as stress resilience, better communication, relationship satisfaction, and improved performance. Team benefits of higher EI include greater cohesion, cooperation, trust, and performance. This study examined whether an emotional competency training could enhance EI abilities in adults, and whether the trained EI abilities related to higher team collaboration, trust, and performance. Undergraduates ( N = 135) participated in teams of three that were randomly assigned to an EI training or control condition. Results indicated that the training did not significantly increase EI abilities, team collaboration, or trust. The training was related to better performance on one of two team tasks. It may be that simply spending time together as a team enhanced performance.
Cell Cycle Progression in the Pericycle Is Not Sufﬁcient for SOLITARY ROOT/IAA14-Mediated Lateral Root Initiation in Arabidopsis thaliana W

To study the mechanisms behind auxin-induced cell division, lateral root initiation was used as a model system. By means of microarray analysis, genome-wide transcriptional changes were monitored during the early steps of lateral root initiation. Inclusion of the dominant auxin signaling mutant solitary root1 ( slr1 ) identiﬁed genes involved in lateral root initiation that act downstream of the auxin/indole-3-acetic acid (AUX/IAA) signaling pathway. Interestingly, key components of the cell cycle machinery were strongly defective in slr1 , suggesting a direct link between AUX/IAA signaling and core cell cycle regulation. However, induction of the cell cycle in the mutant background by overexpression of the D-type cyclin ( CYCD3;1 ) was able to trigger complete rounds of cell division in the pericycle that did not result in lateral root formation. Therefore, lateral root initiation can only take place when cell cycle activation is accompanied by cell fate respeciﬁcation of pericycle cells. The microarray data also yielded evidence for the existence of both negative and positive feedback mechanisms that regulate auxin homeostasis and signal transduction in the pericycle,
The Role of Semantic Mapping Strategy Training on Students ’ EFL Vocabulary Development

This study examined the role of semantic mapping in cultivating the vocabulary competence of grade 8 students of Arsi Negelle Number 1 Elementary School. The sample of the study consisted of 112 students enrolled in two sections, which were randomly selected from five sections and assigned to both treatment and control groups. Quasi experimental design was used in this study. A vocabulary pre-test was given to both groups at the beginning of the study to make sure that they were equivalent and homogenous at the initial stage of the study. The treatment group received semantic mapping as vocabulary teaching/learning technique, but the control group did not receive this treatment. At the end of the study, the same test was given to the two groups to investigate the effect of semantic mapping vocabulary teaching technique in cultivating their word knowledge. The results revealed significant differences between the groups in favor of the treatment group, that is, the treatment group outperformed the control group in vocabulary learning. Therefore, it can be suggested that semantic mapping can be used as an efficient technique for vocabulary teaching.
k2Q: A Quadratic-Form Response Time and Schedulability Analysis Framework for Utilization-Based Analysis

—In this paper, we present a general response-time analysis and schedulability-test framework, called k 2 Q (k to Q). It provides automatic constructions of closed-form quadratic bounds or utilization bounds for a wide range of applications in real-time systems under fixed-priority scheduling. The key of the framework is a k-point schedulability test or a k-point response time analysis that is based on the utilizations and the execution times of k − 1 higher-priority tasks. The natural condition of k 2 Q is a quadratic form for testing the schedulability or analyzing the response time. The response time analysis and the schedulability analysis provided by the framework can be viewed as a " blackbox " interface that can result in sufficient utilization-based analysis. Since the framework is independent from the task and platform models, it can be applied to a wide range of applications. We show the generality of k 2 Q by applying it to several different task models. k 2 Q produces better uniprocessor and/or multiprocessor schedulability tests not only for the traditional sporadic task model, but also more expressive task models such as the generalized multi-frame task model and the acyclic task model. Another interesting contribution is that in the past, exponential-time schedulability tests were typically not recommended and most of time ignored due to high complexity. We have successfully shown that exponential-time schedulability tests may lead to good polynomial-time tests (almost automatically) by using the k 2 Q framework. Analogously, a similar concept to test only k points with a different formulation has been studied by us in another framework, called k 2 U, which provides hyperbolic bounds or utilization bounds based on a different formulation of schedulability test. With the quadratic and hyperbolic expressions, k 2 Q and k 2 U frameworks can be used to provide many quantitive features to be measured, like the total utilization bounds, speed-up factors, etc., not only for uniprocessor scheduling but also for multiprocessor scheduling.
A conceptual model for managing sexual pain with somatocognitive therapy in women with provoked vestibulodynia and implications for physiotherapy practice

ABSTRACT Somatocognitive therapy is a multimodal physiotherapy treatment developed in the early 2000s to alleviate the burden of chronic pelvic pain. In recent years, somatocognitive therapy has been further developed to treat women with provoked vestibulodynia. This prevalent gynecological pain condition is a subgroup of chronic pelvic pain and the most common form of vulvodynia. Provoked vestibulodynia is a neglected multifactorial pain condition of unknown cause, adversely affecting women’s sexual life, relation to their partners and their psychological health. Pain is located at the vulvar vestibule and is provoked by touch or pressure such as sexual intercourse. In the management of sexual pain, somatocognitive therapy combines bodily exploration, pain education, cognitive coping strategies and structured homework to improve sexual function and reduce pain. To support these processes, developing a sound therapeutic alliance with the patient is essential. The aim of this article is to provide a conceptual model for managing provoked vestibulodynia with somatocognitive therapy, including a theoretical rational for this treatment. We base our conceptual model on the biopsychosocial model, i.e., considering the complex interplay of biomedical, emotional/cognitive, psychosexual and interpersonal factors in provoked vestibulodynia management. In addition, implications for practice and a detailed description of somatocognitive therapy for provoked vestibulodynia will be provided, to allow replication in clinical practice and in clinical trials.
Preparation and in vitro and in vivo evaluation of an isoliquiritigenin-loaded ophthalmic nanoemulsion for the treatment of corneal neovascularization

Abstract Isoliquiritigenin (ISL), as a natural flavonoid, has been proven to have therapeutic potential for corneal neovascularization (CNV) treatment; however, its therapeutic use is restricted due to its poor aqueous solubility and limited bioavailability. To overcome these limitations, a novel ISL-loaded nanoemulsion (ISL-NE) was designed for inhibiting CNV in this study. ISL-NE formulation was composed of propylene glycol dicaprylate (PGD), Cremophor® EL (EL35), polyethylene glycol 400 (PEG 400) and adding water with sodium hyaluronate, its particle size was 34.56 ± 0.80 nm with a low polydispersity index of less than 0.05, which suggested a narrow size distribution. The results demonstrated that ISL-NE released higher and permeated more drug than ISL suspension (ISL-Susp) in in vitro drug release and ex vivo corneal permeation study. ISL-NE showed no cytotoxicity in human corneal epithelial cells toxicity study, which was consistent with the result of ocular irritation study in rabbit eyes. ISL-NE had bioavailability 5.76-fold, 7.80-fold and 2.13-fold higher than ISL-Sups in tears, cornea and aqueous humor after a single dose of ISL-NE, respectively. Furthermore, the efficacy of ISL-NE treatment (0.2% ISL) was comparable to that of dexamethasone treatment (0.025%) in the inhibition of CNV in mice model. Enzyme-linked immunosorbent assay (ELISA) showed that the expressions of corneal vascular endothelial growth factor (VEGF-A) and matrix metalloproteinase (MMP-2) were decreased. In conclusion, the ISL-NE demonstrated excellent physicochemical properties, good tolerance, and enhanced ocular bioavailability. It could be a promising, safe, and effective treatment for CNV.
Testing the association of relative growth rate and adaptation to climate across natural ecotypes of Arabidopsis.

• Ecophysiologists have reported a range of relationships, including intrinsic trade-offs across and within species between plant relative growth rate in high resource conditions (RGR) versus adaptation to tolerate cold or arid climates, arising from trait-based mechanisms. Few studies considered ecotypes within a species, in which the lack of a trade-off would contribute to a wide species range and resilience to climate change. • For 15 ecotypes of Arabidopsis thaliana in a common garden we tested for associations between RGR versus adaptation to cold or dry native climates and assessed hypotheses for its mediation by 15 functional traits. • Ecotypes native to warmer, drier climates had higher leaf density, leaf mass per area, root mass fraction, nitrogen per leaf area, and carbon isotope ratio, and lower osmotic potential at full turgor. RGR was statistically independent of the climate of the ecotype native range and of individual functional traits. • The decoupling of RGR and cold or drought adaptation in Arabidopsis is consistent with multiple stress resistance and avoidance mechanisms for ecotypic climate adaptation and would contribute to the species' wide geographic range and resilience as the climate changes.
A Controlled Study in CPR—Survival in Propensity Score Matched Full-Code and Do-Not-Resuscitate ICU Patients

Background Cardiopulmonary Resuscitation (CPR) causes significant injuries and increased cost among transiently resuscitated patients that do not survive their hospitalizations. Descriptive studies show zero and near-zero percent survival for CPR recipients with high Apache II scores. Despite these factors, no controlled studies exist in CPR to guide patient selection for CPR candidacy. Our objective was therefore to perform a controlled study in CPR to inform recommendations for CPR candidacy. We hypothesize that the protective effects of CPR decrease as illness severity increases, and that Full-Code status provides no survival benefit over Do-Not-Resuscitate (DNR) status for patients with the highest predicted mortality by Apache IV score. Methods We performed propensity-score matched survival analyses between Full-Code and DNR patients after stratifying by predicted mortality quartiles using Apache IV scores. Primary outcomes were mortality hazard ratios. Secondary outcomes were Median Survival Differences, ICU LOS, and tracheostomy rates. Results Among 17,710 propensity-score matched ICU encounters, DNR status was associated with greater mortality in the first through third predicted mortality quartiles. There was no difference in survival outcomes in the fourth quartile (HR 0.99, p = .96). There was a stepwise decrease in the mortality hazard ratio for DNR patients as quartiles increased. Conclusion Full-Code status provides no survival benefit over DNR status in individuals with greater than 75% predicted mortality by Apache IV score. There is a stepwise decrease in survival benefit for Full-Code patients as predicted mortality increases. We propose that it is reasonable to consider a very high predicted mortality by Apache IV score a contraindication to CPR given the lack of survival benefit seen in these patients. Larger studies with similar methods should be performed to reinforce or refute these findings.
‘Jumping the first hurdle’: Framing action research questions using the Ice Cream Cone Model

The importance of good research questions is well recognised in the research community. The difficulty lies in actually formulating these research questions, an issue which both beginning and established researchers have expressed concerns about. This article reports on an innovative framing device which was developed for international trainers and teachers to help them ‘jump the first hurdle’ and write a ‘good’ research question to specifically drive a cycle of action research. Through a staged exploration of the thoughts and perceptions of Kazakhstani trainers who used the Ice Cream Cone Model, findings highlight strong support for the use of the framing device and the ‘logical steps’ it provides for producing small-scale action-based research questions. The value of this framing device for teacher researchers and those involved in supporting teachers to carry out action research will be considered following an exploration of model-generated research questions.