Miracle-dz/UniFAR-FTUs huggingface dataset:
Supplementary Material to Sparse Coding and Dictionary Learning with Linear Dynamical Systems

Dynamical Systems Wenbing Huang, Fuchun Sun, Lele Cao, Deli Zhao, Huaping Liu and Mehrtash Harandi 1 Department of Computer Science and Technology, Tsinghua University, State Key Lab. of Intelligent Technology and Systems, Tsinghua National Lab. for Information Science and Technology (TNList); 3 Australian National University & NICTA, Australia; {huangwb12@mails, fcsun@mail, caoll12@mails, hpliu@mail}. tsinghua.edu. cn, 2 zhaodeli@gmail.com, 3 Mehrtash.Harandi@nicta.com. au,
Tracking performance of DA and DD multiuser timing synchronizers for short code DS-CDMA systems

We consider a direct-sequence code-division multiple-access system operating over frequency-selective multipath and slowly Rayleigh fading channels. In order to implement RAKE reception, the delays of the different paths have to be estimated and the estimates have to be updated. We extend interference mitigation to this estimation problem and design timing recovery schemes accounting for the intersymbol interference and the multiple-access interference present in the signal. Starting from the maximum likelihood approach, we derive data-aided and decision-directed early-late synchronizers and study their tracking performance. The advantage of the interference mitigating synchronizer is illustrated. The sensitivity of the synchronizer to imperfect knowledge of path gains and to near-far situations is also investigated.
Joint pathology and platelet-rich plasma therapies

Introduction: At the beginning of the new millennium, there was a breakthrough in platelet-rich plasma (PRP) therapy for tissue repair. The mechanisms governing the effects of this therapy in joint pathology remain largely unexplored. Areas covered: This review is primarily based on PubMed and Web of Knowledge searches with the terms osteoarthritis in combination with PRP, treatment, cartilage, synovium, platelets, inflammation and/or angiogenesis. This search was completed by a manual search for relevant studies. We mainly include papers from the last 5 years. The concept of dynamic reciprocity is used to shape understanding of the spatial relationship between cells and their microenvironments as well as between tissues within the joint. We describe the processes of joint injury and pathology relevant to the mechanism of action of PRP, and elaborate insights into how PRP components may influence inflammation, angiogenesis, cell death and cartilage chondroprotection. Expert opinion: PRP therapies are more complicated than previously acknowledged, and an understanding of the fundamental processes and pivotal molecules involved will hopefully be elucidated soon. This challenge is to provide a comprehensive description of the relationship between PRP components, healing mechanisms and clinical outcomes. Although PRP therapies in clinical trials await assessment, they have shed light on new avenues of management because of their effects on repair functions.
CXCR2 signaling regulates KRAS(G12D)-induced autocrine growth of pancreatic cancer

Pharmacological inhibition of RAS, the master regulator of pancreatic ductal adenocarcinoma (PDAC), continues to be a challenge. Mutations in various isoforms of RAS gene, including KRAS are known to upregulate CXC chemokines; however, their precise role in KRAS-driven pancreatic cancer remains unclear. In this report, we reveal a previously unidentified tumor cell-autonomous role of KRAS(G12D)-induced CXCR2 signaling in mediating growth of neoplastic PDAC cells. Progressively increasing expression of mCXCR2 and its ligands was detected in the malignant ductal cells of Pdx1-cre;LSL-Kras(G12D) mice. Knocking-down CXCR2 in KRAS(G12D)-bearing human pancreatic duct-derived cells demonstrated a significant decrease in the in vitro and in vivo tumor cell proliferation. Furthermore, CXCR2 antagonists showed selective growth inhibition of KRAS(G12D)-bearing cells in vitro. Intriguingly, both genetic and pharmacological inhibition of CXCR2 signaling in KRAS(G12D)-bearing pancreatic ductal cells reduced the levels of KRAS protein, strongly implying the presence of a KRAS-CXCR2 feed-forward loop. Together, these data demonstrate the role of CXCR2 signaling in KRAS(G12D)-induced growth transformation and progression in PDAC.
MAJOR LAMININ‐BINDING AND F‐ACTIN‐LINKED GLYCOPROTEINS OF NEUTROPHILS

Two major EHS‐laminin‐binding membrane glycoproteins—with apparent molecular masses of 50kD and 18kD—were shown by protein blotting in membrane fractions of porcine neutrophils. These galectin‐like glycoproteins (binding probably via the N‐acetyllactosamine sequences to laminin) could also be detected by labelled F‐actin in protein blots. Following 35min adhesion to the plastic surface, the relative amount of the 18kD protein increased considerably in the light (plasma membrane) and in the dense (intracellular) membrane fractions of the attached cells; the 50kD polypeptide (identified as a CD14‐like protein) seemed to accumulate characteristically in the dense membrane fraction. These observations imply that direct connections could be formed between membrane glycoproteins and microfilaments during cell—substrate adhesion which may be preceded by enhanced cell surface targeting of certain adhesion receptors.
Leaf Mitochondria Modulate Whole Cell Redox Homeostasis, Set Antioxidant Capacity, and Determine Stress Resistance through Altered Signaling and Diurnal Regulation Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.009464.

To explore the role of plant mitochondria in the regulation of cellular redox homeostasis and stress resistance, we exploited a Nicotiana sylvestris mitochondrial mutant. The cytoplasmic male-sterile mutant (CMSII) is impaired in complex I function and displays enhanced nonphosphorylating rotenone-insensitive [NAD(P)H dehydrogenases] and cyanide-insensitive (alternative oxidase) respiration. Loss of complex I function is not associated with increased oxidative stress, as shown by decreased leaf H2O2 and the maintenance of glutathione and ascorbate content and redox state. However, the expression and activity of several antioxidant enzymes are modified in CMSII. In particular, diurnal patterns of alternative oxidase expression are lost, the relative importance of the different catalase isoforms is modified, and the transcripts, protein, and activity of cytosolic ascorbate peroxidase are enhanced markedly. Thus, loss of complex I function reveals effective antioxidant crosstalk and acclimation between the mitochondria and other organelles to maintain whole cell redox balance. This reorchestration of the cellular antioxidative system is associated with higher tolerance to ozone and Tobacco mosaic virus.
The significance of calcium phosphate crystals in the synovial fluid of arthritic patients: the "pseudogout syndrome". II. Identification of crystals.

FULL TEXT FULL TEXT     In the course of examining over 200 consecutive specimens of synovial fluid with phase contrast and polarized light microscopy, a collection of fluids from seven patients was obtained containing significant amounts of an unknown crystalline material. Since crystalline urates had previously been identified from the joint fluids of patients with acute and chronic gout it was initially thought that some of these patients had this disorder. With increased experience with this group, however, it became evident that such was not the case: There were significant differences clinically between the gouty patients and the group under discussion; the serum urate levels The Significance of Calcium Phosphate Crystals in the Synovial Fluid of Arthritic Patients: The Pseudogout Syndrome: II. Identification of Crystals PUBMED ARTICLES Crystal structure of the yeast Rad7-Elc1 complex and assembly of the Rad7-Rad16-Elc1-Cul3 complex. DNA Repair (Amst) 2019; Novel Insights into Peptide Binding and Conformational Dynamics of UHRF1. Structure 2019;27(3):408-410. View More Results provided by: CONTENT Home Latest Issues Channels CME/MOC In the Clinic Journal Club Web Exclusives INFORMATION FOR Author Info Reviewers Press Readers Institutions / Libraries / Agencies Advertisers SERVICES Subscribe Renew Alerts Current Issue RSS Latest RSS In the Clinic RSS Reprints & Permissions Contact Us Help About Annals About Mobile Patient Information Teaching Tools Annals in the News
Perceived Barriers to Internet-Based Health Communication on Human Genetics

The Internet has emerged as potential vehicle for distributing health communication to millions of individuals because it is interactive, user controlled, and offers breadth and depth of information. However, its widespread use by the public may be limited due to three overarching concerns: privacy and confidentiality, information accuracy and perceptions of credibility, including limited credibility of some government-sponsored web sites. To explore the potential of using the Internet, especially for delivering information on human genetics communication, 15 focus groups and one interview were conducted with African American and European American adult males and females in a southeastern town. We found that the participants recognized great potential in the Internet for health communication on human
Cholesterol Presence Detection Using Iris Recognition

Arcus senilis is a whitish ring-shaped or bowshaped deposit in the cornea. It is recognized as a sign of hyperlipidemia and is also associated to coronary heart disease (CHD). Iridology is an alternative method to detect diseases using iris’s pattern observation. Iridologists believe that the whitish deposit on the iris is sign of heart diseases. We develop the simple and non-intrusive automation system to detect cholesterol presence using iris recognition (image processing). This system applies iris recognition method to isolate the iris area, normalization process and lastly determining the cholesterol presence using thresholds and histogram method to determine the threshold value. The result showed that the incidence of cholesterol was high when Eigen value exceeds a threshold value. Index Terms — Arcus-Senilis biometric-identification, Cardio-vascular diseases, Corneal-arcus, Iridology, Iris recognition.
How Well Does Renal Transplantation Cure Hyperparathyroidism?

BACKGROUND Most patients with end-stage renal disease will develop hyperparathyroidism (HPT). Transplantation reportedly resolves HPT in most cases. Currently, guidelines recommend a watchful waiting approach to HPT for the first 12 months after the transplantation to allow maximal allograft function. The purpose of our study is to examine the incidence and impact of HPT, defined as an elevated parathyroid hormone (PTH) level, after renal transplantation in a contemporary cohort. METHODS Primary kidney transplantation was performed on 1609 patients from January 1, 2004, to June 6, 2012. Patients were stratified by timing of achieving normal serum PTH levels, and a multivariate logistic regression was constructed to determine predictive variables. Kaplan-Meier analysis was then performed on overall graft survival based on PTH normalization. RESULTS Four hundred eighty-eight (30.3%) patients achieved normal PTH within 1 year posttransplant. Four hundred twenty-seven (26.6%) attained normal PTH between 1 and 2 years, with the remaining 694 (43.1%) categorized as having HPT. Patients achieving normal PTH within 12 months of transplantation had a significantly longer median graft survival (7.33 years) compared with those patients who normalized between 12 and 24 months (4.92 years, P < 0.001), and those with HPT (5.13 years, P < 0.001). Comparing normalization of PTH by 2 years to HPT patients, obesity (P < 0.001), months on dialysis (P < 0.001), and delayed graft failure (P = 0.006) were predictive of nonnormalization. Overall, allograft survival analysis revealed a survival advantage for patients who normalize PTH within 24 months of transplantation (P = 0.038). CONCLUSIONS Renal transplant resolves HPT in 56.9% of patients at 2 years. Resolution within the first year portends longer graft survival. Therefore, earlier intervention for HPT should be considered.
Scalable flow-based network processor for premium network services

This paper presents OmniFlow system that is suitable for future Internet and premium network services requiring multi-layer protocol processing. It is implemented with multi-core processors running a flow-based packet processing for high parallelism performance. It provides for shortening development time, cutting down system cost, and scalability. Its key technology is a flow-based network processor that contains 40 RISC cores, being implemented as ASIC. The network processor is the 40Gbps packet forwarding programmable engine to process incoming packets through two SPI-4.2s.
Mobilization of Tn5 insertions from Rhizobium fredii by pJB3JI

Techniques for in vivo cloning were used with the fast-growing nitrogen-fixing soybean microsymbiont R. fredii USDA 191. Selection for transfer of Tn5 insertions from R. fredii USDA 191 containing the gene-mobilizing plasmid pJB3JI provided recombinants at up to 400 times the background mutation level. These techniques may be useful for future genetic analysis of R. fredii.
Effect of dosing frequency on bisphosphonate medication adherence in a large longitudinal cohort of women.

OBJECTIVE To compare medication adherence with daily vs weekly bisphosphonate dosing for the treatment or prevention of osteoporosis in a broad US retail pharmacy database population. PATIENTS AND METHODS From October 2002 through September 2003, the medication possession ratio (MPR = days of supply/365 days) was used to assess medication adherence. The MPR was calculated by use of daily and weekly bisphosphonate doses in a longitudinal cohort of patients who received prescriptions from 14,000 US retail pharmacies. Patient prescription Information was from a database accessed through NDCHealth in Atlanta, Ga. Adequate adherence was defined as sufficient medication supply to ensure antifracture efficacy (MPR, > or =80%). The effects of patients' age, method of prescription payment, and pattern of past osteoporosis medication use on medication adherence also were evaluated. RESULTS Of 211,319 study patients, 177,552 (84%) were taking weekly bisphosphonates vs 33,767 (16%) taking the daily prescription. Although significantly more patients taking the weekly compared with the daily bisphosphonates had adequate medication adherence, only about one third of patients in the daily dosing group and fewer than one half in the weekly dosing group achieved adequate adherence. Patients new to bisphosphonates had the worst medication adherence over the year (25.2% for weekly vs 13.2% for daily dosing; P<.001). The highest proportion of adequately adherent patients was among those continuing to take their existing weekly bisphosphonates; however, even in this group, only about 48% exhibited adequate medication adherence. CONCLUSIONS Once-weekly dosing of bisphosphonates for the treatment or prevention of osteoporosis was associated with better medication adherence than daily dosing during a 1-year observation period. However, even with weekly dosing, adherence remained inadequate in more than one half of patients. These findings indicate that ways to improve medication adherence in the treatment or prevention of osteoporosis are still needed.
Virus Progeny of Murine Cytomegalovirus Bacterial Artificial Chromosome pSM3fr Show Reduced Growth in Salivary Glands due to a Fixed Mutation of MCK-2

ABSTRACT Murine cytomegalovirus (MCMV) Smith strain has been cloned as a bacterial artificial chromosome (BAC) named pSM3fr and used for analysis of virus gene functions in vitro and in vivo. When sequencing the complete BAC genome, we identified a frameshift mutation within the open reading frame (ORF) encoding MCMV chemokine homologue MCK-2. This mutation would result in a truncated MCK-2 protein. When mice were infected with pSM3fr-derived virus, we observed reduced virus production in salivary glands, which could be reverted by repair of the frameshift mutation. When looking for the source of the mutation, we consistently found that virus stocks of cell culture-passaged MCMV Smith strain are mixtures of viruses with or without the MCK-2 mutation. We conclude that the MCK-2 mutation in the pSM3fr BAC is the result of clonal selection during the BAC cloning procedure.
Play in two societies: pervasiveness of process, specificity of structure.

The present study compared Argentine (N = 39) and U.S. (N = 43) children and their mothers on exploratory, symbolic, and social play and interaction when children were 20 months of age. Patterns of cultural similarity and difference emerged. In both cultures, boys engaged in more exploratory play than girls, and girls engaged in more symbolic play than boys; mothers of boys engaged in more exploratory play than mothers of girls, and mothers of girls engaged in more symbolic play than mothers of boys. Moreover, in both cultures, individual variation in children's exploratory and symbolic play was specifically associated with individual variation in mothers' exploratory and symbolic play, respectively. Between cultures, U.S. children and their mothers engaged in more exploratory play, whereas Argentine children and their mothers engaged in more symbolic play. Moreover, Argentine mothers exceeded U.S. mothers in social play and verbal praise of their children. During an early period of mental and social growth, general developmental processes in play may be pervasive, but dyadic and cultural structures are apparently specific. Overall, Argentine and U.S. dyads utilized different modes of exploration, representation, and interaction--emphasizing "other-directed" acts of pretense versus "functional" and "combinatorial" exploration, for example--and these individual and dyadic allocentric versus idiocentric stresses accord with larger cultural concerns of collectivism versus individualism in the two societies.
The induction of tolerance by skin homografts on newborn rats.

Immunological tolerance can be produced in a small proportion of rats grafted at birth with foreign homologous skin. In spite of the regional origin of the antigenic stimulus provided by such a homograft, the tolerance which it produces is certainly systemic, because it extends to homografts transplanted later in life to a different part of the body. Evidence of a regional component in the tolerance produced by a skin homograft transplanted at birth was not obtained. Extirpation of a skin homograft one month after its transplantation at birth weakens the state of tolerance that prevails two months after birth, but does not abolish it completely. It is likely but not certain that skin homografts transplanted at birth produce tolerance of thyroid homografts transplanted from the same donors two months after birth.
Laboratory Diagnosis of Sexually Transmitted Diseases in Facilities Within the United States: Results of a National Survey

Background and Objectives: The diagnosis of many sexually transmitted diseases (STD) requires laboratory testing. The authors assessed the effects of the introduction of new tests and regulations on STD testing. Study Design: A questionnaire survey was mailed to a random sample of facilities listed in the STD Referral Database inquiring about tests offered, changes in testing, and reasons for changes. Results: Responses from 405 facilities were analyzed. Most responding facilities collected specimens for nontreponemal tests for syphilis (352 of 405 [86.9%]). Since each facility's information was last updated, the number reporting testing for Chlamydia trachomatis rose from 160 of 405 (39.5%) to 288 of 405 (71.1%), but testing for gonorrhea and chancroid decreased (365 of 405 [90.1%] to 328 of 405 [81%], and 182 of 405 [44.9%] to 32 of 405 [7.9%], respectively). Of 364 responses to a question on changes in tests performed in the last 2 years, 249 (68.4%) reported no change, 81 (22.3%) reported an increase, and 37 (10.2%) reported a decrease. The most frequently added tests were nonculture tests for C. trachomatis (34 of 81 [42%]), and the most frequent reason for adding tests was targeted funding (25 of 81 [30.9%]). The most frequently discontinued tests were cultures and gram stains for gonorrhea (15 of 37 [40.5%]) and other in‐house tests (9 of 37 [24.3%]). Most facilities that discontinued testing cited the Clinical Laboratory Improvement Act as the reason (34 of 37 [91.9%]; 95% confidence interval = 78.1%, 98.3%). Conclusions: The number of facilities testing for C. trachomatis has increased with funding and with the availability of nonculture tests, but the number of those testing for chancroid and gonorrhea has decreased. Implementation of the Clinical Laboratory Improvement Act may be associated with a decrease in the number of facilities performing tests for STD.
Modeling Negative User Stories is Risky Business

It is not always the case that a software system is used in the manner it is envisioned originally by software engineers. In this paper, in the context of an agile project, negative interactions are addressed by equipping the 'conventional' user story engineering process with conceptual models for negative user story, negative role, and negative uses.
Synthesized pulsed bias for device characterization

In this work we present a method capable of realising perfectly shaped bias pulses in practical measurement setups. With the proposed technique any user-defined pulse-shape can be generated, only limited by the bandwidth of the generation and acquisition system (i.e., speed of the DAC, modulator/driver and ADC). The detrimental effects on the pulse shape due to the connecting cables, the parasitic effects of the bias network and the non-linear loading provided by the device, can be fully eliminated. The unique capabilities of this method are experimentally demonstrated by accurately realizing sub-100ns voltage pulses with amplitudes up to 35V at the device reference plane.
Connectivity in fMRI : A Review and a Preview

In recent years there has been an increased interest in the analysis of functional brain networks. The goal of these analyses is to better understand how brain regions interact and how this depends upon experimental conditions and behavioral measures. In this work we provide firstly, a review of existing methods of functional brain network analysis pointing to limitations of current approaches. But secondly, we go beyond a review by providing a preview: sketches of a number of emerging methods, written by experts in these new approaches, which can overcome these limitations.