Miracle-dz/UniFAR-FTUs huggingface dataset:
Advancements in ocular gene therapy delivery: vectors and subretinal, intravitreal, and suprachoroidal techniques

ABSTRACT Introduction Ocular gene therapy represents fertile ground for rapid innovation, with ever-expanding therapeutic strategies, molecular targets, and indications. Areas covered Potential indications for ocular gene therapy have classically focused on inherited retinal disease (IRD) but more recently include acquired retinal diseases, such as neovascular age-related macular degeneration, geographic atrophy, and diabetic retinopathy. Ocular gene therapy strategies have proliferated recently, and include gene augmentation, gene inactivation, gene editing, RNA modulation, and gene-independent gene augmentation. Viral vector therapeutic constructs include adeno-associated virus and lentivirus and continue to evolve through directed evolution and rationale design. Ocular gene therapy administration techniques have expanded beyond pars plana vitrectomy with subretinal injection to intravitreal injection and suprachoroidal injection. Expert opinion The success of treatment for IRD, paired with the promise of clinical research in acquired retinal diseases and in administration techniques, has raised the possibility of in-office gene therapy for common retinal disorders within the next 5 to 10 years.
High energy three-body breakup of three-nucleon systems

OF THE DISSERTATION HIGH ENERGY THREE-BODY BREAKUP OF THREE-NUCLEON SYSTEMS by Tigran Abrahamyan Florida International University, 2007 Miami, Florida Professor Misak M. Sargsian, Major Professor The main goal of this dissertation was to study twoand three-nucleon Short Range Correlations (SRCs) in high energy three-body breakup of 3He nucleus in 3 He(e, e'NN)N reaction. SRCs are characterized by quantum fluctuations in nuclei during which constituent nucleons partially overlap with each other. A theoretical framework is developed within the Generalized Eikonal Approximation (GEA) which upgrades existing medium-energy methods that are inapplicable for high momentum and energy transfer reactions. High momentum and energy transfer is required to provide sufficient resolution for probing SRCs. GEA is a covariant theory which is formulated through the effective Feynman diagrammatic rules. It allows self-consistent calculation of single and double re-scatterings amplitudes which are present in three-body breakup processes. The calculations were carried out in detail and the analytical result for the differential cross section of 3 He(e, e'NN)N reaction was derived in a form applicable for programming and numerical calculations. The corresponding computer code has been developed and the results of computation were
Bhutanese Pre-service Teachers’ Self-Efficacy Beliefs towards Teaching Secondary Mathematics

Prospective teachers’ self-efficacy beliefs determine the success of teaching and learning in their future professional practices. Teachers with high self-efficacy are believed to have more confidence and success in teaching as compared to those teachers with low self-efficacy. Thus, this study aimed at examining the Bhutanese pre-service teachers’ self-efficacy beliefs towards teaching secondary mathematics. The study employed a survey design within the positivist methodological framework. The study consisted of 81 pre-service teachers who responded to the secondary mathematics teachers’ self-efficacy beliefs questionnaire (SMTSEBQ), an abridged version of several past instruments. This instrument assessed their perceived self-efficacy in terms of process standards of school mathematics. Findings of the study revealed that the Bhutanese pre-service teachers generally perceived their self-efficacy beliefs towards teaching mathematics somewhat positively. Comparison of the pre-service teachers’ mean scores on the five SMTSEBQ scales in terms of gender revealed that there was a statistically significant difference for problem-solving and reasoning-proof scales. In regard to programme level, there was a statistically significant difference in their self-efficacy beliefs on the four scales, except for the communication scale. The study is distinctive because it is the first study investigating into the pre-service teachers’ self-efficacy beliefs towards teaching secondary mathematics in Bhutanese context.
Screening for acetylcholinesterase inhibition, lipid peroxidation inhibition and antioxidant activity of medicinal plants from Morocco

Acetylcholinesterase (AChE), hydrolyzes acetylcholine to choline and acetate, thereby terminating this neurotransmitter effect at cholinergic synapses. Therefore, AChE inhibition is used for counterbalance the cholinergic deficit in Alzheimer’s disease (AD) patients. In the present work, in order to find new plant acetylcholinesterase inhibitors, the hydroalcoholic extracts from seventeen medicinal plant species were screened for their acetylcholinesterase inhibition activity, as well as total phenolic (TPC) and flavonoids contents (TFC) and antioxidant activity using ORAC (Oxygen Radical Absorbance Capacity) assay, and their ability to inhibit lipid peroxidation. The results revealed that Rumex acetosa, Taraxacum officinaleand Hypericum perforatumextracts possessing the highest TPC and TFC, were the most effective in terms of ORAC antioxidant activity, and acetylcholinesterase inhibition, in addition to their ability to inhibit liposomes peroxidation, suggesting that those plant species may provide a substantial source of secondary metabolites, which act as natural antioxidants and acetylcholinesterase inhibitors, and may be beneficial in the treatment of AD.
Incidence and Predictors of Pregnancy among HIV Positive Women on ART in North West Ethiopia, a Retrospective Cohort Study

Objective: The objective of this study was to identify the prevalence and significant factors of incidence of pregnancy among HIV positive women under ART follow up. Methods: A retrospective cohort study was employed and a sample size of 429 was selected using simple random sampling technique. Both chi-square test of association and multiple binary logistic regression analysis were used. Results: The study has shown that 21.2% of women were pregnant during the follow-up. Variables like, WHO clinical stage, spouse’s HIV status, marital status, contraception use, body weight, occupation, CD4 count, age and time of ART were significant predictors of incidence of pregnancy. Conclusion: Women with advance WHO clinical stage were less likely to be pregnant. Women, who are married, employed, had never used contraceptive methods were more likely to had pregnancy. When CD4 cell count and body weight increase, incidence of pregnancy also increases and women who had longer time on ART were more likely to be pregnant. Health institutions and clinicians should be cautious when the patients have faced advanced WHO clinical stage and low CD4 count. We would like to put remarks of increasing employment of HIV Positive women, providing effective services of ART health care, and studying further investigation for the general wellbeing of mothers and their respective potentially born children.
CASE REPORT Use of ozone therapy to control chronic pain in equine laminitis

Purpose Laminitis is the inflammation of the dermal and epidermal blades of the hull. The use of ozone has already demonstrated promising effects in horses, through postoperative analgesia, antioxidant effect in athletic animals and even chronic laminitis. Thus, the objective of this article is to describe the use of ozone therapy in different methodologies (intramuscular points, acupoints and footbath) in the aid of pain control in an equine with chronic laminitis.
Mobile Virtual Assistant for Continuous Ambulatory Peritoneal Dialysis Complication Detection

Peritoneal dialysis (PD) is an alternative treatment of home-based dialysis for Acute Kidney Injury (AKI). A patient who undergoes PD requires self-management skills to deliver and manage dialysis at home effectively. The effluent dialysate of PD patients can be an indicator for early diagnosis complications in Peritoneal dialysis. Under normal circumstances, the appearance of effluent dialysate is transparent to yellowish clear. Changes in turbidity level or color of effluent dialysate indicate an extra or intraperitoneal abnormality. This study aims to develop an image processing model to detect and classify effluent dialysate of PD patients for early warning of complications. The model was built into the mobile application system. The dataset was obtained from patients, and secondary data were used. Image augmentation is used to enhance the quantity of data by nine times. The data set were divided for train and validation within the 8:2 ratio. The result shows that our system has a high accuracy of 94.7% and minimal loss. testing, and System Usability Scale testing. Those criteria show that the SahabatCAPD Application can perform functionally and assist medical personnel as a CAPD patient monitoring system.
Managing relapsed refractory lymphoma with palliative oral chemotherapy: A multicentre retrospective study

PEP‐C (prednisolone, etoposide, procarbazine and cyclophosphamide) is an orally administered daily chemotherapy regimen used with palliative intent in relapsed refractory lymphoma. To our knowledge, no data on PEP‐C have been reported since the original group described the regimen. Here we present a multicentre retrospective cohort reporting our use of PEP‐C in 92 patients over an 8‐year period. We find that even heavily pretreated lymphoma can respond to PEP‐C, particularly low‐grade lymphoma (including mantle cell) and lymphoma that was sensitive to the previous line of systemic therapy (chemosensitive). These characteristics may help in the selection of patients likely to derive benefit. The median overall survival of patients with chemosensitive lymphoma treated with PEP‐C is 217 days. Within the limitations of a retrospective cohort, we find that PEP‐C is well tolerated: the most common toxicity leading to discontinuation is marrow suppression. We suggest that PEP‐C should be considered for patients with relapsed refractory lymphoma in two settings: first, where there is no licensed alternative; and second, where the licensed alternative is an intravenous drug and the patient would prefer to choose an oral chemotherapy option.
The complex nature of the Seyfert galaxy NGC 7592

Long slit spectra of NGC 7592 were taken on Sep. 26 to 30, 1989 at the 1.52 cm European Southern Observatory (ESO) telescope, equipped with a Boller and Chivens spectrograph and an RCA High Resolution charge coupled device (CCD) camera. The problem of the nature of Region C is addressed at first. C shows an heliocentric radial velocity very similar to that of Regions A and B. Moreover, the arm departing from C is most probably a tidal tail, because its extension is large and its orientation is peculiar. The high H alpha luminosity of C is typical of a starburst nucleus. These facts argue in favor of C being the nucleus of a third galactic component (southern component S) physically interacting with the SE component of NGC 7592. The directions of the velocity vectors in various regions of NGC 7592 are marked. It is noteworthy that the SE component rotates clockwise, if the radial velocity difference delta v sub r from its nucleus B is due to rotation. Under the same assumption for the delta v sub r = v sub r-v sub r, A, the NW component seems to rotate counterclockwise. Thus, the gas in the regions where the two galactic bodies are in contact moves in the same way, suggesting that a prograde encounter is occurring. It is known (e.g., Toomre and Toomre, 1972) that prograde encounters have the most disruptive effects on the interacting galaxies, leading to the formation of tidal tails. The interpretation of the wing of the NW component in terms of a tidal tail thus appears very likely. A similar situation holds for the interaction between SE and S too, where S rotates counterclockwise. The interpretation of the arm departing from C as a tidal tail is supported also in this case. The difference in radial velocity between A and B (delta v sub r approx. equal - 40 km s(exp-1)) and the morphology of NGC 7592 suggests that the NW component is beyond the SE one and is approaching it. The most heavily reddened regions (E(B - V) approx. equals 0.7, derived from the H alpha/H beta ratio) are B2 and B4, namely the regions between A and B. Moreover, the small difference in radial velocity between A,B,C suggests that the three galaxies form a bound system, and their kinematics hints that they are most probably in the early stage of a merging phenomenon.
An Optimization Methodology for Turbines Driven by Pulsed Detonation Combustors

A step-change in efficiency of gas turbine technology and, subsequently, an emissions reduction from this technology requires conceptual changes. Substituting conventional combustion chambers with pressure gain combustion in the form of pulsed detonation combustion (PDC) is one of the promising methods that can reduce gas turbine emissions significantly. Nevertheless, the component matching for the respective systems and specifically that of turbine expanders working with the exhaust flow of PDC tubes is still not solved. The unsteady nature of PDC exhaust flow makes 3D-CFD simulations too expensive to be applied in optimization loops in early design stages. To address this question, the present paper introduces a new cost-effective but reliable methodology for turbine analysis and optimization, based on the unsteady exhaust flow of pulsed detonation combustors. The methodology unitizes a robust unsteady one-dimensional solver, a meanline performance analysis, and an adaptive surrogate optimization algorithm. A two-stage axial turbine is optimized considering all unsteady flow features of a hydrogen-air PDC configuration with five PDC tubes. A three-dimensional URANS simulation is performed for the optimized geometry and the baseline to evaluate the methodology. The results showed that the optimized turbine produces 16% lower entropy than the original one. Additionally, the turbine output power is increased by 14% by the optimized design. Based on the results, it is concluded that the approach is fast and reliable enough to be applied in optimizing any turbine working with unsteady flows, more specifically in PDC applications.
TheInhibitoryEffectofPolyphenon60fromGreenTeaonMelanin and Tyrosinase in Zebrafish and A375 Human Melanoma Cells

Institute of Biochemistry, University of Sindh, Jamshoro 76080, Pakistan Department of Zoology, University of Sindh, Jamshoro 76080, Pakistan Department of Biology, College of Science, University of Bahrain, Sakhir 32038, Bahrain Department of Agro-Environmental Sciences, Kyushu University, Fukuoka, Japan Department of Biochemistry, Shah Abdul Latif University, Khairpur, Pakistan Department of Food Science and Biotechnology, Gachon University, Gyeonggi-do 13120, Republic of Korea Department of Biology, Kongju National University, Gongju, Chungnam 32588, Republic of Korea Department of Pharmacy, Faculty of Allied Health Sciences, Daodil International University, Dhaka 1207, Bangladesh
Simple Algorithms for Multi-term Bell-like Bases and Their Quantum Correlations

We introduce two multiple qubit controlled-unitary gates with different working principles. We employ these gates and existing quantum gates to propose simple and efficient algorithms that generate multi-term orthonormal entangled Bell-like bases. All algorithms thus far known for constructing entangled bases turn out to be special cases of our method. The Bell-like states in any basis is superposition of $2^m$-terms with equal probabilities (that is, their amplitudes being $\pm 1/\sqrt{2^m}$). The orthogonality of the basis does not permit arbitrary amplitudes. The quantum correlations of these bases are investigated; we find that the Bell-like bases obtained using different controlled-unitaries have different entanglement contents. We also learn that monogamy score is able to distinguish these bases in the situations where other quantum correlations fail to do so indicating that monogamy score is a more fundamental quantum correlation measure. Our approach can be extended to qudit systems as well.
The Effect of Voluntary Leadership on the Performance of SACCOS in Wakiso District, Uganda

actively with others arrive at decisions particular interest. Studies suggest that might be steward ethical/authentic Abstract: Purpose: The purpose of this paper is to establish the effect of voluntary leadership onthe performance of SACCOS in Wakiso District, Uganda through the volunteer leaders’ reflection of commitment, self-efficacy and practice. Design/Methodology/Approach: The study is undertaken using a quantitative research design with hypothesis being tested using structural equation modelling on data (n = 176) from 120active SACCOS in Wakiso District in Uganda. Findings: The research findings show that volunteer leaders’ ability to reflect commitment, self-efficacy and undertake effective leadership practice correlate strongly with SACCOS’ performance and that these relationships are significant. Originality/value: The study findings are critical in providing empirical evidence on the concept of voluntary leadership and its influence on performance of organisations generally and SACCOS in particular. The findings do not only expose the nature of voluntary leadership as a formidable practice but also dispel erstwhile beliefs that leaders are better motivated by extrinsic benefits rather than intrinsic ones. To the best of the authors’ understanding and against available literature, no studies have been undertaken on the concepts of voluntary leadership and SACCOS’ performance within the specific context of Wakiso District in Uganda.
The issues of fast flow paths through UZ fractures, their importance relative to matrix flow, the degree of matrix-fracture interactions, and how the repository will affect the flow regime still

The presentations, without exception, were very useful in terms of providing a general overview of ongoing work at Yucca Mountain (YM). They generally did not provide a lot of detail of the current status of fundamental and applied flow and transport research dealing with YM. As such I will provide only limited feedback on individual papers or projects, but rather give overall impressions of ongoing research. These impressions are based on the presentations, the handouts, and perusal of several documents and papers focusing on YM, including especially review papers by Flint et al. (2001) and Eddebbarh et al. (2003), and several papers in a special JCH issue on YM edited by Bodvarsson et al. (2003). References are given at the end of this memo.
Amygdala-cortical collaboration in reward learning and decision making

Adaptive reward-related decision making requires accurate prospective consideration of the specific outcome of each option and its current desirability. These mental simulations are informed by stored memories of the associative relationships that exist within an environment. In this review, I discuss recent investigations of the function of circuitry between the basolateral amygdala (BLA) and lateral (lOFC) and medial (mOFC) orbitofrontal cortex in the learning and use of associative reward memories. I draw conclusions from data collected using sophisticated behavioral approaches to diagnose the content of appetitive memory in combination with modern circuit dissection tools. I propose that, via their direct bidirectional connections, the BLA and OFC collaborate to help us encode detailed, outcome-specific, state-dependent reward memories and to use those memories to enable the predictions and inferences that support adaptive decision making. Whereas lOFC→BLA projections mediate the encoding of outcome-specific reward memories, mOFC→BLA projections regulate the ability to use these memories to inform reward pursuit decisions. BLA projections to lOFC and mOFC both contribute to using reward memories to guide decision making. The BLA→lOFC pathway mediates the ability to represent the identity of a specific predicted reward and the BLA→mOFC pathway facilitates understanding of the value of predicted events. Thus, I outline a neuronal circuit architecture for reward learning and decision making and provide new testable hypotheses as well as implications for both adaptive and maladaptive decision making.
Kuhuang injection exerts a protective effect by activating PPAR-γ in an in vitro model of chlorpromazine-induced cholestatic liver injury constructed by tissue engineering

Abstract Context Kuhuang (KH) injection is a widely used anticholestatic drug in the clinic and the mechanisms are still unclear. Objective This study uses a new 3D tissue-engineered (TE) liver platform to study the ability of kuhuang to ameliorate liver injury induced by chlorpromazine (CPZ) and the possible mechanisms involved. Materials and methods The TE livers (n = 25) were divided into 5 groups (n = 5 livers/group) as 3D, 3D + CPZ, 3D + CPZ + KH, 3D + CPZ + GW9662 (a PPARγ inhibitor) and 3D + CPZ + KH + GW9662. The treatments with kuhuang (1 mg/mL) and GW9662 (10 μmol/L) were given to the desired groups on the 7th day of the experimental process. 20 μmol/L CPZ was added on the 8th day. Results According to the 2D experimental results, the minimum effective concentration of kuhuang is 10 μg/mL and the optimal effective concentration is 1 mg/mL. Kuhuang ameliorated tissue damage in the TE livers both in terms of tissue structure and culture supernatant. Kuhuang significantly reduced TBA accumulation (38%) and downregulated CYP7A1 (38%) and CYP8B1 (79%). It reduced hepatic levels of ROS (14%), MDA (27%) but increased the levels of GSH (41%), SOD (12%), BSEP (4.4-fold), and MRP2 (74%). Moreover, kuhuang downregulated DR5 (99%) but increased the mRNA expression of PPARγ (4-fold). Molecular docking analyses determined the bioactivity of the active compounds of kuhuang through their specific bindings to PPARγ. Conclusions Kuhuang could alleviate CPZ-induced cholestatic liver injury by activating PPARγ to reduce oxidative stress. Applying kuhuang for the treatment of CPZ-induced liver injury could be suggested.
On large deviations of coupled diffusions with time scale separation

We consider two Ito equations that evolve on different time scales. The equations are fully coupled in the sense that all coefficients may depend on both the "slow" and the "fast" processes and the diffusion terms may be correlated. The diffusion term in the "slow" process is small. A large deviation principle is obtained for the joint distribution of the slow process and of the empirical measure of the fast process. By projecting on the slow and fast variables, we arrive at new results on large deviations in the averaging framework and on large deviations of the empirical measures of ergodic diffusions, respectively. The proof of the main result relies on the property that exponential tightness implies large deviation relative compactness. The identification of the large deviation rate function is accomplished by analysing the large deviation limit of an exponential martingale.