Miracle-dz/UniFAR-FTUs huggingface dataset:
The Use of Hosted Enterprise Applications by SMEs: A Dual Market and User Perspective

This deliberately dual perspective paper seeks to deepen our understanding of the engagement of SMEs in hosted enterprise applications in the UK. The emergence and development of the ASP sector has attracted much interest and highly optimistic forecasts for revenues. The paper starts by considering ICT adoption by SMEs in general before reviewing the provision of hosted enterprise applications in the US and UK (market perspective). The study is extended by qualitative empirical data collected by semi‐structured interviews with SME users of hosted enterprise applications (user perspective) and subsequent analysis in order to develop the key findings and conclusions. From an SME user perspective the key findings to emerge from the study include: 1) confirmation that ICT infrastructure was no longer a barrier to adoption; 2) the pragmatic approach taken to security issues; 3) the use of both multiple information systems and multiple service providers; 4) the financial attractiveness of the rental model; and .
Exploring E-Government Impact on Shanghai Firms' Informatization Process

Abstract On the premise of the process model and the resource‐based view, the study uses government regulation policies, as well as e‐government actions, as an environmental resource to investigate the impacts on firms' IT usage. By analysing the survey data from 1,540 firms across 14 industries in Shanghai, the study contributes several insights to the IT usage and e‐business practice of Chinese firms. First of all, this study sheds light on the value creation process of firms' informatization in Shanghai and validates the route from IT investment to value realization. Second, the findings suggest that e‐government actions influence firms' IT infrastructure development, while government promotion and regulation policies influence a firm's IT management decision. However, there is no evidence showing the government impact on firms' IT usage level. Third, the study finds that e‐government approaches and government promotion policies have significant impact on manufacturing firms.
Local therapy and treatment costs of chronic, venous leg ulcers with electrical stimulation (Dermapulse®): A prospective, placebo controlled, double blind trial

The purpose of our study was the evaluation of the therapeutic benefit and the economical profit of low‐frequency pulsed current applied to therapy‐resistant venous leg ulcers. We investigated 39 patients in a prospective, placebo‐controlled, double blind study on the effect of low‐frequency pulsed current (Dermapulse®) on healing in chronic venous ulcers during a 4‐month course of treatment. All patients had chronic venous ulcers. The following criteria were recorded: ulcer size, pain, capillary density, and transcutaneous oxygen partial pressure. In verum group 3, ulcers healed and ulcer area was reduced significantly. In placebo group two ulcers healed. Ulcer size was reduced significantly in each group (paired test), the difference of ulcer area reduction between the “verum” and the placebo group (unpaired test) was not significant. Capillary density in the ulcer increased in both groups. In verum group, electrical stimulation led to rapid and lasting reduction of pain (unpaired test, p=0.049). By means of the process calculation method for the subgroup of outpatients this treatment method was economically effective. Electrical stimulation seems to be a viable treatment option for therapy‐resistant venous leg ulcers.
Mentoring and Professional Development in Careers Services in Higher Education.

Abstract Mentoring is examined as a support mechanism for trainees undertaking new in-service professional qualifications for the Association of Graduate Careers Advisory Services (AGCAS). An initial pilot scheme proved that mentoring was viable in the AGCAS context. An outline is presented of how the transition was made from a pilot group of eight trainees in one region to a national scheme, providing mentors for over fifty trainees. The selection procedure for mentors, the process of matching them with trainees, the regional network for induction training and support, and the documentation associated with the mentoring scheme, are described.
Prechemotherapy antimullerian hormone, age, and body size predict timing of return of ovarian function in young breast cancer patients

Endocrine measures of ovarian reserve before breast cancer treatment may predict postchemotherapy ovarian function, providing prognostic information at the time of cancer diagnosis. The objectives of this study were 1) to determine whether prechemotherapy levels of antimullerian hormone (AMH), follicle‐stimulating hormone (FSH), and inhibin B (inhB) are associated with the return of ovarian function after chemotherapy and 2) to generate a prognostic score for ovarian recovery in young women with breast cancer.
Provider‐based research networks may improve early access to innovative colon cancer treatment for African Americans treated in the community

African American (AA) patients with colon cancer (CC) experience worse outcomes than whites partly due to differential treatment. The National Cancer Institute's Community Clinical Oncology Program (CCOP), a provider‐based research network, adopts and diffuses innovative CC treatments quickly. The authors hypothesized that CCOP participation would lessen racial differences in the receipt of oxaliplatin, an innovative treatment for CC, among patients with stage III CC in the community.
An Introduction to Human Services

Woodside and McClam's text provides a solid introduction to the profession of human services. It provides a historical context of the field as well as a practical overview of the profession and the skills needed to succeed as a human services worker. Readers explore such concepts as serving the whole person, using an interdisciplinary approach, interacting with helper and client, training generalists, and empowering clients.
Analysis of thyroid malignant pathologic findings identified during 3 rounds of screening (1997‐2008) of a cohort of children and adolescents from Belarus exposed to radioiodines after the Chernobyl accident

Recent studies of children and adolescents who were exposed to radioactive iodine‐131 (I‐131) after the 1986 Chernobyl nuclear accident in Ukraine exhibited a significant dose‐related increase in the risk of thyroid cancer, but the association of radiation doses with tumor histologic and morphologic features is not clear.
Anesthesia Case of the Month.

A 9.5-year-old 20.8-kg (45.8-lb) spayed female Border Collie was referred to the Washington State University Veterinary Teaching Hospital for evaluation of excessive and uncontrollable panting. According to the owner, the panting had begun suddenly 2 nights before with no obvious cause. The dog had had a heart murmur for 2 years for which it had been prescribed enalapril (10 mg, PO, q 24 h). The referring veterinarian obtained 2 radiographic views of the thorax to rule out congestive heart failure, but did not notice any radiographic abnormalities, and the dog was subsequently referred to the cardiology service at the Washington State University Veterinary Teaching Hospital for further evaluation of the heart murmur and excessive panting. The owner reported that the dog had been very restless and was unable to sleep or eat properly because of the nonstop panting and was drinking an excessive amount of water. The dog had a littermate that had died suddenly of an unknown cause, but a heart murmur had been identified prior to the dog’s death. On initial physical examination at the Veterinary Teaching Hospital, the dog was alert and responsive. Body condition score was 5 on a scale from 1 to 9. The dog’s mucous membranes were pink and moist, and capillary refill time was < 2 seconds. The dog had a rectal temperature of 38.2°C (100.7°F) and pulse rate of 76 beats/min and was panting excessively. No crackles or wheezes were identified during thoracic auscultation, but a grade III/VI heart murmur loudest at the left apex was heard. Results of abdominal palpation were unremarkable, and no peripheral lymphadenopathy was noted. Neurologic and musculoskeletal examinations did not reveal any abnormalities. No abnormalities were detected on a CBC, but serum biochemical analyses revealed slightly high alanine aminotransferase activity (307 U/L; reference range, 0 to 112 U/L), high SUN concentration (34 mg/dL; reference range, 9 to 26 mg/dL), and slightly low total protein concentration (5.1 g/dL; reference range, 5.5 to 7.5 g/dL). Serum D-dimer concentration was unremarkable (< 250 ng/mL; reference range, < 250 ng/mL), and prothrombin time (7.3 seconds; reference range, 6.4 to 8.2 seconds) and activated partial thromboplastin time (10.8 seconds; reference range, 8.4 to 14.8 sec-
The value of a wound score for diabetic foot infections in predicting treatment outcome: A prospective analysis from the SIDESTEP trial

Scoring the severity of a diabetic foot wound infection may help assess the severity, determine the type and urgency of antibiotic and surgical treatment needed, and predict clinical outcomes. We developed a 10‐item diabetic foot infection wound score (results could range from 3 to 49 [least to most severe]) incorporating semi‐quantitative grading of both wound measurements and various infection parameters. Using data from a prospective diabetic foot infection antibiotic trial (SIDESTEP), we evaluated the score's accuracy in predicting outcome, analyzed its components and tested it for consistency, construct, and validity. Wound scores for 371 patients significantly correlated with the clinical response; it was favorable at the follow‐up assessment in 94.8% with a baseline score ≤12 compared with 77.0% with a score >19. Scores demonstrated good internal consistency (Cronbach's α >0.70 to <0.95). Patients with more severe wounds had higher scores, supporting construct validity. Excluding scores for wound discharge (purulent and nonpurulent), leaving an eight‐item score, provided better measurement statistics. This easily performed wound score appears to be a reliable, valid, and useful tool for predicting clinical outcomes. Further validation studies in different patient populations should refine the items included.
Project storyboards: catalysts for collaborative improvement

This action‐orientated evaluation uses case studies from project facilitators involved in three different collaborative improvement programmes in the UK; medicines management services, cancer processes and services for older adults. The objective of this evaluation was to compare and contrast their perspectives of the benefits and limitations of storyboards, with the aim of feeding back to organisers of large‐scale improvement programmes and users of the collaborative methodology, how the impact of the storyboard process can be positive and constructive. Storyboards are an effective technique for improvement project teams to describe their project, demonstrate progress and share information with other improvement teams working on similar topics, as part of a collaborative improvement process. Additional benefits include using the design and production of storyboards as an opportunity to develop team relationships and to provide those team members who desire it, with a chance to use their creative abilities in a positive way.
The bacteriology of chronic venous leg ulcer examined by culture‐independent molecular methods

The bacterial microbiota plays an important role in the prolonged healing of chronic venous leg ulcers. The present study compared the bacterial diversity within ulcer material from 14 skin graft operations of chronic venous leg ulcers using culture‐based methods and molecular biological methods, such as 16S rRNA gene sequencing, fingerprinting, quantitative polymerase chain reaction, and fluorescence in situ hybridization. Each wound contained an average of 5.4 species but the actual species varied between wounds. The diversity determined by culture‐based methods and the molecular biological methods was different. All the wounds contained Staphylococcus aureus, whereas Pseudomonas aeruginosa was in six out of 14 wounds. Molecular methods detected anaerobic pathogens in four ulcers that were not detected with anaerobic culture methods. Quantitative polymerase chain reaction was used to compare the abundance of S. aureus and P. aeruginosa at different locations in the ulcers and their numbers varied greatly between samples taken at different locations in the same ulcer. This should be considered when ulcers are investigated in routine clinical care. The differences between the results obtained with culture‐based and molecular‐based approaches demonstrate that the use of one approach alone is not able to identify all of the bacteria present in the wounds.
Managing Suicidal Risk: A Collaborative Approach

managing suicidal risk a collaborative approach What to say and what to do when mostly your friends love reading? Are you the one that don't have such hobby? So, it's important for you to start having that hobby. You know, reading is not the force. We're sure that reading will lead you to join in better concept of life. Reading will be a positive activity to do every time. And do you know our friends become fans of managing suicidal risk a collaborative approach as the best book to read? Yeah, it's neither an obligation nor order. It is the referred book that will not make you feel disappointed.
Inflammation‐induced activation of the indoleamine 2,3‐dioxygenase pathway: Relevance to cancer‐related fatigue

Cancer‐related fatigue (CRF) is a common complication of cancer and its treatment that can significantly impair quality of life. Although the specific mechanisms remain poorly understood, inflammation is now considered to be a distinct component of CRF in addition to effects of depression, anxiety, insomnia, and other factors. One key biological pathway that may link inflammation and CRF is indoleamine 2,3‐dioxygenase (IDO). Induced by inflammatory stimuli, IDO catabolizes tryptophan to kynurenine (KYN), which is subsequently converted into neuroactive metabolites. Here we summarize current knowledge concerning the relevance of the IDO pathway to CRF, including activation of the IDO pathway in cancer patients and, as a consequence, accumulation of neurotoxic KYN metabolites and depletion of serotonin in the brain. Because IDO inhibitors are already being evaluated as therapeutic agents in cancer, the elucidation of the relationship between IDO activation and CRF in cancer patients may lead to novel diagnostic and clinical approaches to managing CRF and its debilitating consequences. Cancer 2015;121:2129–2136. © 2015 American Cancer Society.
Differential effects of planktonic and biofilm MRSA on human fibroblasts

Bacteria colonizing chronic wounds often exist as biofilms, yet their role in chronic wound pathogenesis remains unclear. Staphylococcus aureus biofilms induce apoptosis in dermal keratinocytes, and given that chronic wound biofilms also colonize dermal tissue, it is important to investigate the effects of bacterial biofilms on dermal fibroblasts. The effects of a predominant wound pathogen, methicillin‐resistant S. aureus, on normal, human, dermal fibroblasts were examined in vitro. Cell‐culture medium was conditioned with equivalent numbers of either planktonic or biofilm methicillin‐resistant S. aureus and then fed to fibroblast cultures. Fibroblast response was evaluated using scratch, viability, and apoptosis assays. The results suggested that fibroblasts experience the same fate when exposed to the soluble products of either planktonic or biofilm methicillin‐resistant S. aureus, namely limited migration followed by death. Enzyme‐linked immunosorbent assays demonstrated that fibroblast production of cytokines, growth factors, and proteases were differentially affected by planktonic and biofilm‐conditioned medium. Planktonic‐conditioned medium induced more interleukin‐6, interleukin‐8, vascular endothelial growth factor, transforming growth factor‐β1, heparin‐bound epidermal growth factor, matrix metalloproteinase‐1, and metalloproteinase‐3 production in fibroblasts than the biofilm‐conditioned medium. Biofilm‐conditioned medium induced more tumor necrosis factor‐α production in fibroblasts compared with planktonic‐conditioned medium, and suppressed metalloproteinase‐3 production compared with controls.
Combined chemotherapy for acute promyelocytic leukemia: a meta-analysis

ABSTRACT Background: This study evaluates the efficacy of combined chemotherapy for the management of acute promyelocytic leukemia (APL). Method: Literature search was carried out in several electronic databases. Meta-analyses were performed to achieve weighted effect sizes of overall survival (OS), disease-free survival (DFS), complete remission (CR) rate, and relapse rate. Metaregression analyses were performed to evaluate the factors affecting CR and relapse rates. Results: Data from 37 studies (7566 patients) were used for meta-analysis. Median follow-up was 49.24 [95% confidence interval (CI): 41.33, 57.16] months. Five-year OS and DFS were 86.41 [83.97, 88.85] % and 75.42 [67.44, 83.40] %, respectively (pooled effect size [95% CI]). Following induction therapy, 89.77 [87.04, 92.50] % patients achieved CR in 38.25[37.84, 38.65] days and 6.34 [5.98, 6.70] % of the patients died during induction. Induction with all-trans retinoic acid (ATRA), arsenic trioxide (ATO), and daunorubicin (DNR) combination was associated with the highest rate of CR (96.16 [89.92, 92.40] %), followed by ATRA-DNR (94.29 [93.15, 95.43] %), ATRA-DNR-cytarabine (92.04 [88.38, 95.71] %), and ATRA-idarubicin (91.16 [89.92, 92.40] %). Overall relapse rate in the study population was 14.42 [11.97, 16.86] %. Baseline leukocyte count was inversely related to the CR rate. Conclusion: Combined chemotherapy for APL is associated with 90% CR, 14.4% relapse rate, 86% 5-year OS, and 75% 5-year DFS. Induction with ATRA-DNR-ATO is found better than other combinations with respect to CR and relapse rates. Initial leukocyte count may affect prognosis.
Body composition measurements: Clinical and technical considerations

Standard weight-for-age and height-for-age charts have been used for many years to assess growth and body compositions of children, including curves specific to the Prader-Willi syndrome (PWS). However, a number of direct measures of body compositions have been developed in recent years. Dural-energy x-ray absorptiometry (DXA) provides a measure of bone mineral content and bone mineral density for the whole body and at specific bone regions (spine, hip, forearm). This technology now has been extended to include assessment of the body's lean tissue mass and body fat mass. An alternate technique, called bioelectrical impedance analysis (BIA), has gained wide use in recent years as an indirect measure of the fat-free mass. The older, underwater weighing method is giving way to the air-displacement plethysmographic technique for assessing body fatness. Total body potassium still remains the method of choice for a direct assessment of body cell mass, and body nitrogen is recognized as the best assay for body protein mass. Imaging techniques, such as a computer tomography and magnetic resonance imaging, continue to receive increasing attention for body composition assays, especially for the subcutaneous vs. visceral distribution of body fat. Although total body water and extracellular water can be measured by dilution techniques, these methods are slowly being replaced by the BIA assay. When these various techniques are used in combination, the patient's nutritional status can be obtained based on a comprehensive 5-level multicompartment model of the body composition. Each of these methods will be reviewed, and their specific strengths and limitations presented, relative to their application for assessing changes in body composition of the PWS patient. ▪ The Endocrinologist 2000; 10: 57S-62S
Propagation Modeling for ITS Applications in the Roadway Environment

It is expected that the Intelligent Transportation Systems (ITS) of the future will involve communication between vehicles and the roadside. In designing these communication systems it is imperative that one has a sound and detailed understanding of radio-wave propagation in both short-distance roadside and complicated urban environments. In this paper we discuss the type of propagation models that are needed for ITS designers to predict system performance. This paper has approached this problem by examining the radio-wave propagation in the roadway environment over the range of distances and at frequencies that will have the potential to meet the needs of ITS. The requirements of the individual functions of ITS were taken into consideration in addition to what portions of the radio frequency spectrum will be available.
A Short Mental Status Questionnaire

ABSTRACT A mental status questionnaire (MSQ) developed tor use in surveys of the non-institutionalized elderly has been validated against clinical assessment. The MSQ identities moderate and severe cognitive impairment in the elderly. However, using the suggested scoring subjects with mild impairment cannot be separated from normals. The test is short, acceptable and reproducible and rate for false-positives and false-negatives fall well within acceptable limits for use in estimating the prevalence of dementia in the non-institutionalized elderly population. RÉSUMÉ Un examen des fonctions mentales, le MSQ élaboré à l'intention des personnes âgées vivant hors de l'institution a été validé à partir des résultats de l'examen clinique. Il permet de déceler les pertes cognitives modérées et graves, mais les cotes proposées ne distinguent pas les sujets présentant des pertes faibles et les sujets normaux. Le test est court, stable et acceptable. Le taux des écarts positifs and négatifs est compris dans les limites admissibles en vue de l'évaluation du taux de démence précoce dans la population non hospitalisée.
The clinical usefulness of the intraoperative detection of sentinel lymph node metastases by a rapid RT‐PCR system in patients with gastric cancer

The incidence of pathological lymph node metastases in patients with gastric cancer is 5% to 10%, which means that approximately 90% of patients with gastric cancer may undergo unnecessary lymphadenectomy. The precise intraoperative diagnosis of sentinel lymph node (SN) metastases is essential. The purpose of the current study was to verify the usefulness of a rapid reverse transcriptase‐polymerase chain reaction (RT‐PCR) system compared with hematoxylin and eosin staining for such diagnoses.
Development of a scale for job satisfaction assessment in nurses: Development of a scale for job satisfaction assessment in nurses

Objective:To identify the components for nurse job satisfaction,and to develop a scale for job satisfaction assessment in Chinese nurses.Methods:Using literature review and expert consulting,we developed a primary scale consisting of 10 factors and 56 items.After testing with 135 nurses,a nurse job satisfaction scale composing of 8 factors and 38 items was developed,and was used to test 1 185 nurses;the reliability and efficacy of the scale were also assessed.Results:The developed nurse job satisfaction scale was composed of 8 factors(administration,work loads,relationship with colleagues,job,salary and welfare,professional opportunities,work recognition by others,and balance between family and work) and 38 items,and it had good reliability and efficacy.Conclusion:The developed scale can not only help to evaluate job satisfaction among nurses,but also provide evidence for corresponding intervention.