Miracle-dz/UniFAR-FTUs huggingface dataset:
µSWIMMING POOLS FOR CILIATES

Ciliates are very motile cells and as such hard to observe under a microscope. Microfluidic devices give the possibility to constrain these cells in µpools. This device had 40 of such pools in which behaviours of ciliates could be observed, without the cell leaving the field of view. One extraordinary phenomenon is the creation of a vortex at the gullet of the cell, to pull in nutrients. Here we show that the relaxation time of the cilia in motion is 2 to 3.3 seconds.
SARS-CoV-2 Screening Test for Japanese Returnees From Wuhan, China, January 2020

Abstract Background Severe acute respiratory syndrome–related coronavirus 2 (SARS-CoV-2) was found to be the causative microorganism of coronavirus disease 2019 (COVID-19), which started to spread in Wuhan, China. This study was to evaluate the effectiveness of questionnaire, symptoms-based screening, and polymerase chain reaction (PCR) screening of returnees from COVID-19-endemic areas on a chartered flight, to examine the proportion of infected persons and the proportion of asymptomatic persons among infected persons who returned from Wuhan. Methods A retrospective cohort study was done in 7 tertiary medical institutions in Japan. A total of 566 Japanese who returned from Wuhan participated in the study. Results Overall, 11 of the 566 passengers had a positive SARS-CoV-2 PCR result for pharyngeal swabs and 6 were asymptomatic. Only fever differed between SARS-CoV-2-positive and -negative individuals (P < .043). Six of the 11 PCR-positive individuals were asymptomatic; 4 remained positive on day 10, and 1 asymptomatic person tested positive up to day 27. Two of the 11 were negative on the first PCR test and positive on the second. Conclusions Our results will be important insights on screening returnees from locked-down cities, as well as providing important data on the proportion of asymptomatic individuals infected with SARS-CoV-2. A 13-day observation period and a second round of PCR may be effective to screen patients, including asymptomatic infections.
Management of major sucking pests in Cotton by insecticides

All the insecticides tested were superior to untreated check by recording lower population of sucking pests. Among the insecticides tested, acetamiprid 25 SP @ 0.2g/L was effective against aphids, fipronil 5 SC @ 2ml/L and acephate 75 SP @ 1.5g/L were found to be effective against thrips. In case of leafhoppers, fipronil 5 SC @ 2ml/L and imidacloprid 17.8 SL @ 0.4ml/L were found to be promising. Whereas thiamethoxam 5 SG @ 0.2g/L was effective on whiteflies. Increase in plant height was observed in all insecticidal treated plots compared to untreated control.
Early Holocene glacial retreat isolated populations of river otters (Lontra canadensis) along the Alaskan coast

Pleistocene climatic oscillations have resulted in high rates of speciation. Lesser known are speciation events related to recent glacial retreats. During the early Holocene many Alaskan coastal glaciers receded, exposing much of the Kodiak Island Archipelago (KOD), the Kenai Peninsula, and Prince William Sound (PWS). Using fecal DNA analyses on samples collected in KOD, PWS, Kenai Fjords National Park (KEFJ), Katmai National Park and Preserve (KATM), and Vancouver Island, British Columbia (BC), we found isolation by distance to be an important mechanism for the divergence of populations of river otters (Lontra canadensis (Schreber, 1777)) along the Pacific coast. Nonetheless, our results also demonstrated that KOD river otters appear to be more isolated genetically from their mainland conspecifics (approximately 50 km away), as river otters inhabiting PWS are from those in BC (over 2500 km away). In addition, KATM and KOD otters likely differentiated from one ancestral stock that inhabited the southweste.
AJP MS # Revision 1 TRANSLATIONAL PHYSIOLOGY Angiotensin Converting Enzyme-2 (ACE2) confers endothelial protection and attenuates atherosclerosis

Division of Cardiac Surgery and Cardiology, Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Ontario, Canada; Departments of Surgery, Medicine and Physiology, Division of Cardiology, University Health Network, R. Samuel McLaughlin Centre for Molecular and Regenerative Medicine, Heart & Stroke Richard Lewar Centre of Excellence, Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada; IMBA, Institute for Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
Production of Enterobacterial Common Antigen as an Aid to Classification of Newly Identified Species of the Families Enterobacteriaceae and Vibrionaceae

A study on the production of enterobacterial common antigen by recently described or as-yet-undescribed species belonging to the families Enterobacteriaceae and Vibrionaceae was carried out by hemagglutination and hemagglutination inhibition tests with rabbit antisera specific for this antigen. All 28 strains known or presumed to belong to Enterobacteriaceae produced this antigen, and none of the seven strains belonging to Vibrionaceae did so. The results obtained with Tatumella ptyseos and Xenorhabdus species are particularly noteworthy, since they represent species which are atypical for Enterobacteriaceae. It is suggested that the determination of the production of enterobacterial common antigen is a significant aid to classification, particularly when the assignation of a new genus or species to Enterobacteriaceae or to another family presents a problem.
Genetic variability and heterozygosity of cocoa accessions of Parinari (Pa) population, based on microsatellite markers

The objective of this work was to study the genetic variability and the heterozygosity of accessions of the Parinari (Pa) series in the collection of the Active Germplasm Bank (BAG) of the Cocoa Research Center (CEPEC), CEPLAC, Bahia using microsatellite markers. In the present study, 34 accessions of Theobroma cacao L. were used, being 25 of the Parinari series. Twelve microsatellite loci were analyzed generating a total of 49 alleles. Results indicated genetic variability among the Parinari accessions with genetic distances varying from 0.00 to 0.64 and heterozygosity levels between 11 and 72%. About 40% of the accessions presented heterozygosity equal or greater than 50%.
Unconventional superconductivity in a strongly correlated band-insulator without doping

We present a novel route for attaining unconventional superconductivity (SC) in a strongly correlated system without doping. In a simple model of a correlated band insulator (BI) at half-filling we demonstrate, based on a generalization of the projected wavefunctions method, that SC emerges when e-e interactions and the bare band-gap are both much larger than the kinetic energy, provided the system has sufficient frustration against the magnetic order. As the interactions are tuned, SC appears sandwiched between the correlated BI followed by a paramagnetic metal on one side, and a ferrimagnetic metal, antiferromagnetic (AF) half-metal, and AF Mott insulator phases on the other side.
On the Analysis of Model-free Methods for the Linear Quadratic Regulator

Many reinforcement learning methods achieve great success in practice but lack theoretical foundation. In this paper, we study the convergence analysis on the problem of the Linear Quadratic Regulator (LQR). The global linear convergence properties and sample complexities are established for several popular algorithms such as the policy gradient algorithm, TD-learning and the actor-critic (AC) algorithm. Our results show that the actor-critic algorithm can reduce the sample complexity compared with the policy gradient algorithm. Although our analysis is still preliminary, it explains the benefit of AC algorithm in a certain sense.
Power Side-Channel Attacks in Negative Capacitance Transistor

Side-channel attacks have empowered bypassing of cryptographic components in circuits. Power side-channel (PSC) attacks have received particular traction, owing to their noninvasiveness and proven effectiveness. Aside from prior art focused on conventional technologies, this is the first work to investigate the emerging negative capacitance transistor (NCFET) technology in the context of PSC attacks. We implement a CAD flow for the PSC evaluation at design time. It leverages industry-standard design tools, while also employing the widely accepted correlation power analysis (CPA) attack. Using standard-cell libraries based on the 7-nm FinFET technology for NCFET and its counterpart CMOS setup, our evaluation reveals that NCFET-based circuits are more resilient to the classical CPA attack, due to the considerable effect of negative capacitance on the switching power. We also demonstrate that the thicker the ferroelectric layer, the higher the resiliency of the NCFET-based circuit, which opens new doors for optimization and tradeoffs.
Does Palatini Higgs inflation conserve unitarity?

In the conventional metric formulation of gravity, the Higgs Inflation model violates unitarity in the electroweak vacuum in Higgs scattering at the energy scale Λ ∼ MPl /ξ, where ξ ∼ 104 is the non-minimal coupling of the Higgs to the Ricci scalar. In the Palatini formulation it is commonly believed that Λ ∼ MPl /√(ξ), where ξ ∼ 109. Here we reconsider unitarity violation in the electroweak vacuum in the Palatini formulation. We argue that there is no unitarity violation in Higgs scattering in the Palatini non-minimally coupled Standard Model in the electroweak vacuum at energies below the Planck scale. In this case Palatini Higgs Inflation completely conserves unitarity and is consistent at all energies up to those at which quantum gravity becomes important. If true, this would imply that Palatini Higgs Inflation has a significant advantage over metric Higgs Inflation.
Home ranges in adult Scandinavian brown bears (Ursus arctos): effect of mass, sex, reproductive category, population density and habitat type

Annual home-range size indices for 36 male and 52 female adult brown bears Ursus arctos in two study areas in central and northern Scandinavia were estimated to evaluate factors believed to influence home-range size. Male home ranges were larger than home ranges of lone females after controlling for the sexual size dimorphism acting on metabolic needs. Further, home ranges of females with cubs were smaller than home ranges of lone females and females with yearlings. Thus, differences in metabolic need were not able to explain the variation in range size among females of different reproductive categories or between males and females, suggesting roaming behaviour of males in this promiscuous species. Home-range size in both males and females was inversely related to population density along a density gradient that was not linked to food availability. This contradicts the hypothesis that females use the minimum areas that sustain their energy requirements. However, on a large geographical scale a negative relationship between range size and food availability was evident. The annual home ranges in inland boreal environments in Scandinavia are the largest reported for brown bears in Eurasia, and similar to those in inland boreal and montane environments in North America.
The use of bimolecular fluorescence complementation (BiFC) to investigate the functional implications of neuropeptide Y receptor dimerisation and beta-arrestin recruitment

The functional significance of G protein coupled receptor (GPCR) dimerisation remains debatable partly due to the inability to assign pharmacological properties directly to defined dimers. To address this problem, this thesis uses bimolecular fluorescence complementation (BiFC), whereby protein-protein interactions are identified by the fluorescence generated from the association of complementary fluorescent protein fragment tags. The irreversibility of BiFC constrains receptor complexes of precise composition. The 4 Y receptor family members were chosen as model GPCRs as their relative β-arrestin recruitment and regulation by endocytosis remains questionable. BiFC based high content imaging assays quantified the pharmacology of β-arrestin2 recruitment to Y receptors, which correlated with their agonist induced endocytosis (Chapter 3). Targeted mutagenesis, showed key intracellular receptor domains shared in arrestin recruitment and internalisation. Fluorescence recovery after photobleaching, and fluorescence correlation spectroscopy measured the diffusion of fluorescent Y receptor complexes and showed agonist stimulation slowed receptor motility (Chapter 4). A novel BiFC system allowed the correlation of this slowed motility with the behaviour of defined Y receptor/arrestin signalling complexes. BiFC also constrained Y1 receptors or β2-adrenoceptors as dimers of precise composition. Quantitative platereader imaging, measured BiFC dimer internalisation as an indirect readout of β-arrestin recruitment and dimer function (Chapters 5 and 6). Selective mutagenesis showed occupation of a single ligand binding site and the presence of one phosphorylated C terminal domain was sufficient, implying symmetrical binding of β-arrestin to Y1 receptor dimers. Finally Y1/Y5 receptor BiFC heterodimers showed modified pharmacology not evident for other heterodimer combinations. The most striking alterations were switching of Y5 selective antagonists from surmountable to insurmountable antagonism and the ineffectiveness of Y1 antagonists at inhibiting Y1/Y5 dimer responses, suggesting allosteric interactions between the respective protomers. Previous anti-obesity therapies targeting either Y1 or Y5 subtypes have lacked long term efficacy. However novel responses of the Y1/Y5 dimer, and the use of BiFC to screen for selective antagonism, may help identify future treatments for obesity.
Production of methyl-3-orsellinate by organic synthesis or by altered biosynthetic pathways using lichen immobilisates

Methyl-3-orsellinate can be generated from methyl-3-orcinol through the nitration of aryl function to be then reduced to amine group. This last derivative could be the substrat of a diazotonization for the corresponding diazonium salt. After this, a cyanide group could be introduced by nucleophilic substitution using potassium cyanide and then, the carboxyl function could be produced after hydrolysis. Alternatively, methyl-3-orsellinate could be produced by alginate-immobilized, atranorin-producing lichen cells loaded with acetate and treated with sodium azide. Acetate is used by acetyl-CoA carboxylase and aromatic synthase (methyl transfer) to produce methyl-3-orsellinate and its oxidation to haematommoyl alcohol is inhibited by sodium azide.
Anesthesia efficacy of bupivacaine in pregnant participants with breech presentation receiving external cephalic version

Abstract Background The objective of this study is to appraise the efficacy and safety of bupivacaine in pregnant participants with breech presentation (BP) receiving external cephalic version (ECV). Methods: The following electronic databases will be searched from the origin to the January 31, 2020: PUBMED, EMBASE, Cochrane Library, CINAHL, ACMD, PsycINFO, Scopus, OpenGrey, and China National Knowledge Infrastructure. No language and publication time limitations will be applied to all of them. Randomized controlled trials comparing bupivacaine to other interventions for pain relief in pregnant participants with BP undergoing ECV will be included in this study. Two authors will employ the selection of searched records, extraction of essential data from included RCTs, and risk of bias assessment for each eligible trail independently and respectively. Any doubts between 2 authors will be figured out by a third author through discussion. The risk of bias assessment will be judged using Cochrane risk of bias tool. The data pooling and analysis will be performed using RevMan 5.3 software. Results: This study will summarize the up-to-date high-quality evidence and will synthesis the outcome data from that evidence to explore the efficacy and safety of bupivacaine for pain relief in pregnant participants with BP undergoing ECV. Conclusion: The findings of this study may present important guidance for patients, clinical practice, as well as health-policy makers regarding the utilization of bupivacaine for pain relief in pregnant participants with BP receiving ECV. Systematic review registration: PROSPERO CRD42020164409.
Systematic Review of Genus Cerradomys Weksler, Percequillo and Voss, 2006 (Rodentia: Cricetidae: Sigmodontinae: Oryzomyini), with Description of Two New Species from Eastern Brazil

Abstract Cerradomys is a monophyletic genus that includes four known species, Cerradomys subflavus, C. maracajuensis, C. marinhus, and C. scotti, distributed throughout the open vegetation belt across South America, from northeastern Brazil to southeastern Bolivia, and from eastern to northwestern Paraguay. We revised the status of the species currently assigned to this genus by analyzing skins, skulls, karyotypes, and cytochrome b DNA sequences. We also described two novel species, one distributed in the Brazilian states of Minas Gerais, Bahia, and Sergipe, and the other in the states of Paraíba, Pernambuco, Piauí, Ceará, and Maranhão. Molecular analysis suggested the following phylogenetics arrangement: (((C. subflavus–C. sp.n.2) C. sp.n. 1) C. scotti)(C. marinhus–C. maracajuensis)). Apparently, both novel species inhabit the Caatinga domain and penetrated the coastal Atlantic rainforest, differing from the remaining congeneric species that are typical open-area inhabitants.
The Impact of Copyright and Personal Data Laws on the Creation and Use of Models for Language Technologies

The authors address the legal issues relating to the creation and use of language models. The article begins with an explanation of the development of language technologies. The authors analyse the technological process within the framework copyright, related rights and personal data protection law. The authors also cover commercial use of language models. The authors’ main argument is that legal restrictions applicable to language data containing copyrighted material and personal data usually do not apply to language models. Language models are generally not considered derivative works. Due to a wide range of language models, this position is not absolute.
Bayesian Regression Using a Prior on the Model Fit: The R2-D2 Shrinkage Prior

Abstract Prior distributions for high-dimensional linear regression require specifying a joint distribution for the unobserved regression coefficients, which is inherently difficult. We instead propose a new class of shrinkage priors for linear regression via specifying a prior first on the model fit, in particular, the coefficient of determination, and then distributing through to the coefficients in a novel way. The proposed method compares favorably to previous approaches in terms of both concentration around the origin and tail behavior, which leads to improved performance both in posterior contraction and in empirical performance. The limiting behavior of the proposed prior is , both around the origin and in the tails. This behavior is optimal in the sense that it simultaneously lies on the boundary of being an improper prior both in the tails and around the origin. None of the existing shrinkage priors obtain this behavior in both regions simultaneously. We also demonstrate that our proposed prior leads to the same near-minimax posterior contraction rate as the spike-and-slab prior. Supplementary materials for this article are available online.
Probabilistic Powerdomains and Quasi-Continuous Domains

The probabilistic powerdomain $\mathbf V X$ on a space $X$ is the space of all continuous valuations on $X$. We show that, for every quasi-continuous domain $X$, $\mathbf V X$ is again a quasi-continuous domain, and that the Scott and weak topologies then agree on $\mathbf V X$. This also applies to the subspaces of probability and subprobability valuations on $X$. We also show that the Scott and weak topologies on the $\mathbf V X$ may differ when $X$ is not quasi-continuous, and we give a simple, compact Hausdorff counterexample.
Transcript Enrichment Following Biotic Stress of a Gene that Encodes a Calmodulin-Binding, Chloroplast-Targeted Protein in Beta vulgaris L.

An understanding of plant molecular genetics underlying programmed responses to pathogens is sought in order to more fully realize the genome’s potential to resist microbial pathogens A previously devised hypothesis was that a cluster of orthologous genes (COG) consisting of four core plant genes in B. vulgaris as well as several other eudicots may contribute to coordinated expression of two or more genes whose products are critical for managing biotic and other environmental stresses. One of these genes, CaMP encodes a 525-amino acid protein product with an N-terminal signal, an IQ domain from amino acid positions 131 to 153, four regions of intrinsic disorder and four phosphorylation sites that roughly correlate with the regions of intrinsic disorder. The most likely calmodulin-binding site on was predicted by Calmodulin Target Database at amino acid positions 201-209. Sugarbeet plants under biotic stress, i.e., experimental Erwinia betavasculorum infection, showed enrichment of a higher level of CaMP-specific RNA transcript compared with un-inoculated control plants. The results of this study suggest that CaMP encodes a chloroplast
Sensitivities of KM3NeT on decaying dark matter

The discovery of high-energy astrophysical neutrinos by IceCube has opened a new window to the Universe. However, the origin of these neutrinos is still a mystery, and some of them could be a result of dark matter interactions such as decay. Next generation gigaton water-Cherenkov neutrino telescope, KM3NeT, is expected to offer significantly improved energy resolution in the cascade channel, and advantageous viewing condition to the Galactic Center; both important for searches of dark matter decay signals. We study the sensitivity of KM3NeT on dark matter decays by performing a mock likelihood analysis for both cascade and track type events, taking into account both angular and energy information. We find that, combining both channels, KM3NeT is expected to produce world leading limits on dark matter decay lifetime in the PeV mass range, and could test some of the dark matter hints in the current IceCube data.
Fast Monte Carlo Simulation of Dynamic Power Systems Under Continuous Random Disturbances

Continuous-time random disturbances from the renewable generation pose a significant impact on power system dynamic behavior. In evaluating this impact, the disturbances must be considered as continuous-time random processes instead of random variables that do not vary with time to ensure accuracy. Monte Carlo simulation (MCs) is a nonintrusive method to evaluate such impact that can be performed on commercial power system simulation software and is easy for power utilities to use, but is computationally cumbersome. Fast samplings methods such as Latin hypercube sampling (LHS) have been introduced to speed up sampling random variables, but yet cannot be applied to sample continuous disturbances. To overcome this limitation, this paper proposes a fast MCs method that enables the LHS to speed up sampling continuous disturbances, which is based on the Itô process model of the disturbances and the approximation of the Itô process by functions of independent normal random variables. A case study of the IEEE 39-Bus System shows that the proposed method is 47.6 and 6.7 times faster to converge compared to the traditional MCs in evaluating the expectation and variance of the system dynamic response.