Miracle-dz/UniFAR-FTUs huggingface dataset:
Intelligence and creativity share a common cognitive and neural basis.

Are intelligence and creativity distinct abilities, or do they rely on the same cognitive and neural systems? We sought to quantify the extent to which intelligence and creative cognition overlap in brain and behavior by combining machine learning of fMRI data and latent variable modeling of cognitive ability data in a sample of young adults (N = 186) who completed a battery of intelligence and creative thinking tasks. The study had 3 analytic goals: (a) to assess contributions of specific facets of intelligence (e.g., fluid and crystallized intelligence) and general intelligence to creative ability (i.e., divergent thinking originality), (b) to model whole-brain functional connectivity networks that predict intelligence facets and creative ability, and (c) to quantify the degree to which these predictive networks overlap in the brain. Using structural equation modeling, we found moderate to large correlations between intelligence facets and creative ability, as well as a large correlation between general intelligence and creative ability (r = .63). Using connectome-based predictive modeling, we found that functional brain networks that predict intelligence facets overlap to varying degrees with a network that predicts creative ability, particularly within the prefrontal cortex of the executive control network. Notably, a network that predicted general intelligence shared 46% of its functional connections with a network that predicted creative ability-including connections linking executive control and salience/ventral attention networks-suggesting that intelligence and creative thinking rely on similar neural and cognitive systems. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
Reduced activity of GIRK1‐containing heterotetramers is sufficient to affect neuronal functions, including synaptic plasticity and spatial learning and memory

G‐protein inwardly rectifying K+ (GIRK) channels consist of four homologous subunits (GIRK1‐4) and are essential regulators of electrical excitability in the nervous system. GIRK2‐null mice have been widely investigated for their distinct behaviour and altered depotentiation following long‐term potentiation (LTP), whereas GIRK1 mice are less well characterized. Here we utilize a novel knockin mouse strain in which the GIRK1 subunit is fluorescently tagged with yellow fluorescent protein (YFP‐GIRK1) and the GIRK1‐null mouse line to investigate the role of GIRK1 in neuronal processes such as spatial learning and memory, locomotion and depotentiation following LTP. Neurons dissected from YFP‐GIRK1 mice had significantly reduced potassium currents and this mouse line phenotypically resembled GIRK1‐null mice, making it a ‘functional knockdown’ model of GIRK1‐containing channels. YFP‐GIRK1 and GIRK1‐null mice had increased locomotion, reduced spatial learning and memory and blunted depotentiation following LTP.
Effects of S-PBL in Maternity Nursing Clinical Practicum on Learning Attitude, Metacognition, and Critical Thinking in Nursing Students: A Quasi-Experimental Design

Due to the coronavirus disease (COVID-19) pandemic, there are many restrictions in effect in clinical nursing practice. Since effective educational strategies are required to enhance nursing students’ competency in clinical practice, this study sought to evaluate the effectiveness of simulation problem-based learning (S-PBL). A quasi-experimental control group pretest-post-test design was used. Nursing students were allocated randomly to the control group (n = 31) and the experimental group (n = 47). Students in the control group participated in a traditional maternity clinical practicum for a week, while students in the experimental group participated S-PBL for a week. The students in the experimental group were trained in small groups using a childbirth patient simulator (Gaumard® Noelle® S554.100, Miami, USA) based on a standardized scenario related to obstetric care. The students’ learning attitude, metacognition, and critical thinking were then measured via a self-reported questionnaire. Compared with the control group, the pre-post difference in learning attitude and critical thinking increased significantly (p < 0.01) in the experimental group. S-PBL was found to be an effective strategy for improving nursing students’ learning transfer. Thus, S-PBL that reflects various clinical situations is recommended to improve the training in maternal health nursing.
Virus–Host Protein–Protein Interactions between Human Papillomavirus 16 E6 A1 and D2/D3 Sub-Lineages: Variances and Similarities

High-risk strains of human papillomavirus are causative agents for cervical and other mucosal cancers, with type 16 being the most frequent. Compared to the European Prototype (EP; A1), the Asian-American (AA; D2/D3) sub-lineage seems to have increased abilities to promote carcinogenesis. Here, we studied protein–protein interactions (PPIs) between host proteins and sub-lineages of the key transforming E6 protein. We transduced human keratinocyte with EP or AA E6 genes and co-immunoprecipitated E6 proteins along with interacting cellular proteins to detect virus–host binding partners. AAE6 and EPE6 may have unique PPIs with host cellular proteins, conferring gain or loss of function and resulting in varied abilities to promote carcinogenesis. Using liquid chromatography-mass spectrometry and stringent interactor selection criteria based on the number of peptides, we identified 25 candidates: 6 unique to AAE6 and EPE6, along with 13 E6 targets common to both. A novel approach based on pathway selection discovered 171 target proteins: 90 unique AAE6 and 61 unique EPE6 along with 20 common E6 targets. Interpretations were made using databases, such as UniProt, BioGRID, and Reactome. Detected E6 targets were differentially implicated in important hallmarks of cancer: deregulating Notch signaling, energetics and hypoxia, DNA replication and repair, and immune response.
Performance of Optical Coupling Materials in Scintillation Detectors Post Temperature Exposure

In this paper, the room-temperature performance of different optical coupling materials post temperature exposure was tested. The tested couplers included OC431A-LVP, OG0010 optical grease, BLUESIL V-788, and SAINT-GOBAIN BC-630. This was done by subjecting the whole detector with newly applied optical coupling materials to a 2-h temperature exposure—ranging from −20 to 50 °C and then by letting it return to room temperature before collecting a spectrum from a Cs-137 source. The energy resolution at 662 keV was computed as the metric for evaluating the performance. Three trials were run at each coupler–temperature combination. Our results reveal that the performance of all coupling agents do indeed change with temperature after the 2-h exposure. Over all the tested temperature trials, the energy resolution ranged from 11.4 to 14.3% for OC431A-LVP; 10.2 to 14.6% for OG0010; 10 to 13.4% for BLUESIL V-788; and 9.8 to 13.3% for SAINT-GOBAIN BC-630. OC431A-LVP had the lowest variance over the full range, while BC-630 was the most constant for temperatures above 20 °C. Ultraviolet-visible (UV-Vis) spectra experiments were also performed on isolated optical coupling materials to measure the light absorption coefficient. The results show that the temperature-induced variance in light absorption coefficient of each optical coupling materials is one of the reasons for the variance in energy resolution performance. Our findings suggest the need for further investigation into this effect and the recommendation that optical coupling materials need to be selected for the task at hand with greater scrutiny.
Plasma pro- and anti-inflammatory cytokines may relate to cocaine use, cognitive functioning, and depressive symptoms in cocaine use disorder

ABSTRACT Background Inflammation is implicated in cocaine use and associated problems, including depression and cognitive impairment. Objective We assessed 18 cytokines, cocaine use, cognition, and depression in individuals with Cocaine Use Disorder. Our general hypothesis was that higher pro-inflammatory cytokines would relate to more cocaine use, poorer cognition, and more depression, while higher anti-inflammatory cytokines would relate to less cocaine use, better cognition, and less depression. Methods Data were collected from 85 individuals (76.5% male, 80% African American) aged 18–65. The ASI, Shipley-2, and BDI-II assessed frequency and duration of cocaine use, cognition, and depression. Cytokines were tested using Bio-Plex Pro™ assays. Elastic net regression identified which cytokines related to each measure, controlling for confounds. Results Lower IL-29 (B = −0.08, bootstrapped 95%CI = [−0.24,0.07]), scD163 (B = −0.11, bootstrapped 95%CI = [−0.27,0.04]), Eotaxin-1 CCL11 (B = −0.11, bootstrapped 95%CI = [−0.30,0.08]), and higher APRIL/TNFSF13 (B = 0.11, bootstrapped 95%CI = [−0.08,0.30]) related to more frequent cocaine use. Lower IL-29 (B = −0.24, bootstrapped 95% CI = [−2.26,1.79]) and IL-20 (B = −1.62, bootstrapped 95%CI = [−3.53,0.29]) related to longer duration of cocaine use. Higher Eotaxin-2 CCL24 (B = 2.79, bootstrapped 95%CI = [−0.59,6.17]) and TWEAK (B = 2.83, bootstrapped 95%CI = [−0.80,6.45]) related to better cognition. Finally, higher IL-20 (B = −1.83, bootstrapped 95%CI = [−3.70,0.04]) and Osteocalcin (B = −1.56, bootstrapped 95%CI = [−3.81,0.70]) related to lower depressive symptoms. However, none of these relationships survived bootstrapped analyses. Conclusion Pro- and anti-inflammatory cytokines may relate to cocaine use, cognition, and depression, but inconsistent with our hypotheses, higher pro-inflammatory cytokines related to better functioning in several domains. Additionally, cytokines were selected at low frequencies and demonstrated weak relationships with outcomes. These preliminary findings suggest complex relationships between inflammation and cocaine use.
Kriging Predictor for Facial Emotion Recognition Using Numerical Proximities of Human Emotions

Emotion recognition from facial expressions has gained much interest over the last few decades. In the literature, the common approach, used for facial emotion recognition (FER), consists of these steps: image pre-processing, face detection, facial feature extraction, and facial expression classification (recognition). We have developed a method for FER that is absolutely different from this common approach. Our method is based on the dimensional model of emotions as well as on using the kriging predictor of Fractional Brownian Vector Field. The classification problem, related to the recognition of facial emotions, is formulated and solved. The relationship of different emotions is estimated by expert psychologists by putting different emotions as the points on the plane. The goal is to get an estimate of a new picture emotion on the plane by kriging and determine which emotion, identified by psychologists, is the closest one. Seven basic emotions (Joy, Sadness, Surprise, Disgust, Anger, Fear, and Neutral) have been chosen. The accuracy of classification into seven classes has been obtained approximately 50%, if we make a decision on the basis of the closest basic emotion. It has been ascertained that the kriging predictor is suitable for facial emotion recognition in the case of small sets of pictures. More sophisticated classification strategies may increase the accuracy, when grouping of the basic emotions is applied.
Interaction of Tone and Voicing in Mizo

Since the production of fundamental frequency and voicing is determined by the tension in the vocal folds, it is noticed that VOT is affected by the F0 in tone languages. Similarly laryngeal contrasts also affect the F0 of tone. This work studies the interaction between tone and voicing in a lesser-known tone language, Mizo. Mizo has eight stops, that can be categorized into three laryngeal contrasts namely, voiced, voiceless unaspirated, and voiceless aspirated. In the current work, we look into CV syllables produced with the eight Mizo stops with all five vowel categories of the language, produced with four distinct tones in Mizo. The results show a predictable effect of onsets on the F0 of tone and weak effect of tone on VOT duration.
Focal Loss for Punctuation Prediction

Many approaches have been proposed to predict punctuation marks. Previous results demonstrate that these methods are effective. However, there still exists class imbalance problem during training. Most of the classes in the training set for punctuation prediction are non-punctuation marks. This will affect the performance of punctuation prediction tasks. Therefore, this paper uses a focal loss to alleviate this issue. The focal loss can down-weight easy examples and focus training on a sparse set of hard examples. Experiments are conducted on IWSLT2011 datasets. The results show that the punctuation predicting models trained with a focal loss obtain performance improvement over that trained with a cross entropy loss by up to 2.7% absolute overall F 1 -score on test set. The proposed model also outperforms previous state-of-the-art models.
LEARNING INDICATORS OF COOPERATIVE MANAGEMENT IN THE REVIEW OF THE ECONOMIC PERSPECTIVE

The background of the research is to see and examine the economic wheels of the citizens, which in part seems to still have to struggle in carrying out the economic sufficiency of their families, and the purpose of the research is, to provide a solution, how to make a good system in managing a cooperative management system, as an alternative. which need to be studied and studied in a comprehensive manner is, the economic implementation of the cooperative model, around our citizens need to be encouraged, in all fields of life. In this study the authors made a personal approach to the participants, with descriptive qualitative case study models, and this research was conducted with involving 15 participants, for about 14 weeks. The results of this study indicate a significant change in the participants, especially in the field of transactions or purchases, all kinds of their needs
Sagittal Subtalar and Talocrural Joint Assessment Between Barefoot and Shod Walking: A Fluoroscopic Study

The contents of this article were developed under a grant from the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR grant number 90AR5022-01-00 Formerly H133P140023-14). NIDILRR is a Center within the Administration for Community Living (ACL), Department of
Species distribution modelling: Bombina bombina (Linnaeus, 1761) and its main invasive threat Perccottus glenii (Dybowski, 1877) in Latvia under global climate change

Amphibians have been greatly affected by invasive species through direct predation and competition. The invasion in Eurasia of Perccottus glenii (the Chinese sleeper) triggered by climate change may have detrimental consequences for the Fire-bellied toad (Bombina bombina) because the invader can feed upon B. bombina eggs, toads and juveniles. We used correlative species distribution models (SDMs) to infer competitive interaction between the invader and native species and found a significant level of correlation (r=0.636) between both SDMs, meaning there is a considerable overlap of areas of similar habitat suitability related to the species and a potential for competition. For strategical management purposes we mapped areas in Latvia where there are lesser chances for negative interactions between the both species, and where unwanted contact and/or competition between the invader and the toad can be avoided. DOI: http://dx.doi. org/10.5755/j01.erem. 74.4. 21093
Respon Imun Non-spesifik Ikan Gurami (Osphronemus gouramy) yang Diberi Fucoidan dari Ekstrak Rumput Laut Cokelat Padina sp.

Fucoidan merupakan senyawa polisakarida sulfat yang diekstrak dari rumput laut cokelat Padina sp. Fucoidan diketahui mempunyai beberapa bioaktivitas, salah satunya sebagai imunostimulan. Ikan gurami ( Osphronemus gouramy ) ukuran + 100 gr diberi perlakuan fucoidan yang dicampur kedalam pakan dengan dosis 0,2 gr kg -1 pakan (P1), 0,4 gr kg -1 pakan (P2) , 0,6 gr kg -1 pakan (P3) serta kontrol (Po) masing-masing dengan 3 kali ulangan. Hasil penelitian menunjukkan, fucoidan dari ekstrak rumput laut cokelat Padina sp. secara signifikan dapat meningkatkan respon imun non-spesifik terhadap persentase hematokrit, leukokrit dan superoksida anion pada ikan gurami. Perlakuan P3 (0,6 gr kg -1 ) merupakan dosis optimum yang dapat meningkatkan respon imun non-spesifik ikan, menunjukkan fucoidan dapat digunakan dalam budidaya ikan gurami. Kata kunci : fucoidan, Padina sp. , ikan gurami, imun non-spesifik
Estimating basis functions in massive fields under the spatial random effects model

Spatial prediction is commonly achieved under the assumption of a Gaussian random field (GRF) by obtaining maximum likelihood estimates of parameters, and then using the kriging equations to arrive at predicted values. For massive datasets, fixed rank kriging using the Expectation-Maximization (EM) algorithm for estimation has been proposed as an alternative to the usual but computationally prohibitive kriging method. The method reduces computation cost of estimation by redefining the spatial process as a linear combination of basis functions and spatial random effects. A disadvantage of this method is that it imposes constraints on the relationship between the observed locations and the knots. We develop an alternative method that utilizes the Spatial Mixed Effects (SME) model, but allows for additional flexibility by estimating the range of the spatial dependence between the observations and the knots via an Alternating Expectation Conditional Maximization (AECM) algorithm. Experiments show that our methodology improves estimation without sacrificing prediction accuracy while also minimizing the additional computational burden of extra parameter estimation. The methodology is applied to a temperature data set archived by the United States National Climate Data Center, with improved results over previous methodology.
Hydrothermal assisted biological synthesis of Silver nanoparticles by using honey and gomutra (Cow Urine) for qualitative determination of its antibacterial efficacy against Pseudomonas sp. isolated from contact lenses

Background: Biological synthesis of Silver Nanoparticles (AgNPs) by using honey and gomutra shall become biocompatible and cost effective alternative method wherein no extra reducing agents were used which may create problems for living systems and also adds extra cost to the system. Materials and Methods: The crude gomutra and purified honey (1 mg/mL) in sterile distilled water were used for the synthesis of Ag NPs by hydrothermal method. The characterization of Ag NPs was done by UV-Vis Spectroscopy and Scanning Tunneling Microscopy (STM) to study optical and morphological characteristics, correspondingly. The isolation of bacterial culture was carried out by incubation of swabs taken from contact lenses of healthy volunteers, followed by its identification through microscopic and biochemical studies. Antibacterial activity of Ag NPs was performed against Pseudomonas species by anti-well diffusion assay and broth dilution method. Studies were also performed for determination of biofilm reduction by Ag NPs by congo red agar test and tube assay. Results: Silver Nanoparticles were synthesized by using honey and gomutra by hydrothermal method The absorption spectrum of Ag NPs and band gap was found to be at 350 nm and 3.54 eV respectively, for honey and 275 nm and 4.50 eV, respectively, for gomutra by UV-Vis Spectroscopy. STM image showed Ag NP’s cluster morphology on surface at 200 nm for honey and 50 nm for gomutra. Ag NPs was found to be effective antibacterial agent at the concentration of 1mg/mL against Pseudomonas predominantly present in contact lenses and therefore have a may have applications in ophthalmology.
LINKING PERCEIVED SOCIAL SUPPORT TO SOCIAL ENTREPRENEURIAL INTENTION: THE MEDIATING ROLE OF ATTITUDE BECOMING SOCIAL ENTREPRENEUR

Abstract. The present study aims at identifying the social entrepreneurial intention among undergraduates students in Bung Hatta University context by using the theory of planned bahaviour as the research framework. A 10-questionnaire was responded by 150 studens of Bung Hatta University. The data were collected by purposive random sampling method. The questions measured perceived social support, attitude towards becoming a social entrepreneur, and social entrepreneurial intention. The result shows that attitude towards becoming a social entrepreneur full mediation between perceived social support to social entrepreneurial intention. Perceived social support and attitude towards becoming a social entrepreneur showed the positive significant relationship with social entrepreneurial intentions. This research study contributes to the social entrepreneurship literature by introductiong perceived social support and attitude towards becoming a social entrepreneur as antecedents that also explains social entrepreneurial intention formation. Keywords: Perceived social support, attitude towards becoming a social entreprenuer (ATB), social entrepreneurial intention, the theory of planned behaviour
Microblotches on Dermoscopy of Melanocytic Lesions are Associated with Melanoma: A Cross-sectional Study

Numerous dermoscopic structures for the early detection of melanoma have been described. The aim of this study was to illustrate the characteristics of dermoscopic structures that are similar to blotches, but smaller (termed microblotches), and to evaluate their association with other well-known dermoscopic structures. A cross-sectional study design, including 165 dermoscopic images of melanoma was used to define microblotches, and 241 consecutive images of naevi from the HAM10000 database, were studied to evaluate the prevalence of this criterion in both groups. Microblotches were defined as sharply demarcated structures ≤1 mm, with geographical borders visible only with dermoscopy. Microblotches were present in 38.7% of the melanomas and 6.7% of the naevi. Moreover, microblotches were associated with an odds ratio (OR) of malignancy of 5.79, and were more frequent in invasive melanoma than in the in-situ subtype (OR 2.92). Histologically, they correspond to hyperpigmented parakeratosis or epidermal consumption. In conclusion, microblotches are related to melanomas. This finding could help dermatologists to differentiate between naevi and melanomas.
Disentangling the contribution of each descriptive characteristic of every single mutation to its functional effects

Mutational effects predictions continue to improve in accuracy as advanced artificial intelligence (AI) algorithms are trained on exhaustive experimental data. The next natural questions to ask are if it is now possible to gain insights into which attribute of the mutation contributes how much to the mutational effects, and if one can develop universal rules for mapping the descriptors to mutational effects. In this work, we mainly address the former aspect using a framework of interpretable AI. Relations between the physico-chemical descriptors and their contributions to the mutational effects are extracted by analyzing the data on 29,832 variants from 8 systematic deep-mutational scan studies. It is found that the intuitive dependences of fitness and solubility on the distance of the amino acid from active site could be extracted and quantified. The dependence of the mutational effect contributions on the number of contacts an amino acid has or the BLOSUM score descriptor of the change showed universal trends. Our attempts in the present work to explain the quantitative differences in the dependence on conservation and SASA across proteins were not successful. The work nevertheless brings transparency into the predictions, development of rules, and will hopefully lead to uncovering the universalities among these rules.