Miracle-dz/UniFAR-FTUs huggingface dataset:
Electrospun Membrane Surface Modification by Sonocoating with HA and ZnO:Ag Nanoparticles—Characterization and Evaluation of Osteoblasts and Bacterial Cell Behavior In Vitro

Guided tissue regeneration and guided bone regeneration membranes are some of the most common products used for bone regeneration in periodontal dentistry. The main disadvantage of commercially available membranes is their lack of bone cell stimulation and easy bacterial colonization. The aim of this work was to design and fabricate a new membrane construct composed of electrospun poly (D,L-lactic acid)/poly (lactic-co-glycolic acid) fibers sonocoated with layers of nanoparticles with specific properties, i.e., hydroxyapatite and bimetallic nanocomposite of zinc oxide–silver. Thus, within this study, four different variants of biomaterials were evaluated, namely: poly (D,L-lactic acid)/poly (lactic-co-glycolic acid) biomaterial, poly(D,L-lactic acid)/poly (lactic-co-glycolic acid)/nano hydroxyapatite biomaterial, poly (D,L-lactic acid)/poly (lactic-co-glycolic acid)/nano zinc oxide–silver biomaterial, and poly (D,L-lactic acid)/poly (lactic-co-glycolic acid)/nano hydroxyapatite/nano zinc oxide–silver biomaterial. First, it was demonstrated that the wettability of biomaterials—a prerequisite property important for ensuring desired biological response—was highly increased after the sonocoating process. Moreover, it was indicated that biomaterials composed of poly (D,L-lactic acid)/poly (lactic-co-glycolic acid) with or without a nano hydroxyapatite layer allowed proper osteoblast growth and proliferation, but did not have antibacterial properties. Addition of a nano zinc oxide–silver layer to the biomaterial inhibited growth of bacterial cells around the membrane, but at the same time induced very high cytotoxicity towards osteoblasts. Most importantly, enrichment of this biomaterial with a supplementary underlayer of nano hydroxyapatite allowed for the preservation of antibacterial properties and also a decrease in the cytotoxicity towards bone cells, associated with the presence of a nano zinc oxide–silver layer. Thus, the final structure of the composite poly (D,L-lactic acid)/poly (lactic-co-glycolic acid)/nano hydroxyapatite/nano zinc oxide–silver seems to be a promising construct for tissue engineering products, especially guided tissue regeneration/guided bone regeneration membranes. Nevertheless, additional research is needed in order to improve the developed construct, which will simultaneously protect the biomaterial from bacterial colonization and enhance the bone regeneration properties.
Impaired Pharmacokinetics of Amiodarone under Veno-Venous Extracorporeal Membrane Oxygenation: From Bench to Bedside

Background: Adjusting drug therapy under veno-venous extracorporeal membrane oxygenation (VV ECMO) is challenging. Although impaired pharmacokinetics (PK) under VV ECMO have been reported for sedative drugs and antibiotics, data about amiodarone are lacking. We evaluated the pharmacokinetics of amiodarone under VV ECMO both in vitro and in vivo. Methods: In vitro: Amiodarone concentration decays were compared between closed-loop ECMO and control stirring containers over a 24 h period. In vivo: Potassium-induced cardiac arrest in 10 pigs with ARDS, assigned to either control or VV ECMO groups, was treated with 300 mg amiodarone injection under continuous cardiopulmonary resuscitation. Pharmacokinetic parameters Cmax, Tmax AUC and F were determined from both direct amiodarone plasma concentrations observation and non-linear mixed effects modeling estimation. Results: An in vitro study revealed a rapid and significant decrease in amiodarone concentrations in the closed-loop ECMO circuitry whereas it remained stable in control experiment. In vivo study revealed a 32% decrease in the AUC and a significant 42% drop of Cmax in the VV ECMO group as compared to controls. No difference in Tmax was observed. VV ECMO significantly modified both central distribution volume and amiodarone clearance. Monte Carlo simulations predicted that a 600 mg bolus of amiodarone under VV ECMO would achieve the amiodarone bioavailability observed in the control group. Conclusions: This is the first study to report decreased amiodarone bioavailability under VV ECMO. Higher doses of amiodarone should be considered for effective amiodarone exposure under VV ECMO.
An improved FMEA method based on the linguistic weighted geometric operator and fuzzy priority

ABSTRACT Using the group linguistic information aggregation method, this research improved upon conventional failure mode and effect analysis (FMEA), which had the problems of the inevitable subjectivity of expert evaluations, and of the difficulty of determining the weights of experts' evaluations. First, this research treated the three risk factors of FMEA evaluation as linguistic variables and introduced a linguistic weighted geometric (LWG) operator to implement algebraic operations on the results of expert evaluations. This treatment overcame the disadvantage of fuzzy theory-based methods in which decision-making information could be lost due to the twice conversion process. Second, the weights of experts' evaluations were calculated based on the consistency of experts' ranking using a fuzzy priority method. This method placed a lower weight for the experts whose evaluation departed from group consensus, and therefore decreased the impact of the unfairness of experts on evaluation results. Finally, this article demonstrated the effectiveness and applicability of this method by an example of failure-mode analysis on the grinding wheel system of a numerical control machine.
Sustainability appraisals of design-led responses to climate adaptation

Overviewpolicy brief is a milestone from the VCCCAR project Design-led Decision Support for Regional Climate Adaptation. The project explored a new approach to climate change adaptation at the local government scale, addressing the question ‘What could a climate-proof future look like? ’ using a design process to address problems of future uncertainty and risk. A design approach enables new ideas to arise, emphasising uncertainty as part of future thinking whilst allowing a departure from incremental approaches. Design charettes (a form of intensive workshop) were central to this exercise. Charrettes were held in Bendigo and Sea Lake, engaging community members, local government and state government staff and academics in an intensive process of envisaging and designing alternative futures for their locality based on an understanding of local conditions and potential future climate conditions. Those involved in the charrettes found the process challenging and satisfying. Reports from the charrettes are available on the VCCCAR website: www.vcccar. org.au
Flux linkage estimation based loss of excitation relay for synchronous generator

Loss of excitation (LOE) event threatens both the generator and power system stability. Numerous approaches have been proposed for LOE detection, most of which use the impedance trajectory. Such methods may maloperate under system disturbances, especially power swings. This study presents a new approach for LOE detection by estimating the field flux linkage participation (FFLP) in the stator flux linkage. Intrinsically, this newly defined index mainly depends on the generator excitation system and thus highly reduces when an LOE takes place. The FFLP parameter can easily be calculated using stator voltage and current signals. All kinds of LOE events cannot be studied using most available simulation software. To cover all of them, utilising state variables, a generator model connected to a power system is implemented. Performed simulation studies demonstrate that the proposed strategy not only considerably decreases the LOE relay operation time, but also improves the LOE relay security against system disturbances. In addition, the proposed approach is experimentally evaluated on a 10 kVA synchronous generator.
Lean manufacturing and human resources: a systematic literature review on future research suggestions

The purpose of the present study is to identify and classify future research suggestions of Lean Management (LM) which are related to human resources (HR) aspects. Based on a systematic literature review (SLR) of peer reviewed journal articles in LM, a total of 147 articles published in 35 journals during, 2016–2020 by four major management science publishers were collected. The LM-HR future research suggestions identified in the literature were classified into themes through applying the ‘affinity diagram’ which then were prioritised through the ‘Pareto diagram’. An increase in the number of articles with LM-HR future research suggestions is observed during the review period and the study highlights the need for considerable attention to be paid to future suggestions related to training, managerial, cultural and performance aspects of LM. Classification of themes reveals five broad theme categories, namely ‘top and middle management’, ‘employees’, ‘work features’, ‘LM implementation and results’ and ‘national and organisational culture’.
Greenspace Exposure and Obsessive-Compulsive Behaviors in Schoolchildren

Green environments are associated with improved child brain development and mental health. We study cross-sectionally the association of the availability of greenspace at home and school with obsessive-compulsive behaviors (OCB) in primary schoolchildren. Greenspace and tree cover surrounding home and school of 378 children aged 9 to 10 in Barcelona (Spain) were characterized using satellite-based indices [Normalized Difference Vegetation Index (NDVI), Modified Soil Adjusted Vegetation Index (MSAVI), Vegetation Continuous Field (VCF)] across buffers of 100, 300, and 500 m, and distance to the nearest green space. OCB was assessed with the Spence Children’s Anxiety Scale-Parent version. Linear and mixed effects models showed that greenspace at school, but not at home, was significantly related to a reduction in OCB across buffers, with benefits for girls and also children with graduate parents. Higher greenspace around the school might be associated with less obsessive-compulsive behavior in primary schoolchildren, especially in girls and those with higher socioeconomic status.
Melacak Pengaruh Budaya Belajar terhadap Ketangkasan Belajar: Peranan Keterlekatan Kerja sebagai Mediator

Perubahan yang terus-menerus dalam bisnis menuntuk orang-orang dalam organsasi untuk dapat adatif dengan cepat. Ketangkasan belajar (learning agility) menjadi hal strategis dalam pengembanan dan pengelolaan sumber daya manusian. Artikel ini melakukan pengujian secara statistik atas pengaruh dari budaya belajar terhadap ketangkasanan belajar. Apakah budaya belajar memiliki dampak yang langsung ataukah tidak langsung terhadap ketangkasan belajar? Artikel ini didasarkan pada studi empiris terhadap 107 orang manajemen puncak dari beberapa perusahaan terkemuka di Indonesia. Data yang diperoleh dianalisis dengan PLS based SEM dengan menggunaakan SmartPLS versi 3.0. Hasil analisis menyimpulkan bahwa budaya belajar merupakan antesiden dari keterlekatan kerja (work engagement) dan keterlekatan kerja merupakan prediktor yang baik untuk ketangkasan belajar. Karena itu keterlekatan kerja merupakan mediator pada hubungan antara budaya belajar dan ketangkasan belajar. Untuk menjadi pembelajar yang tangkas dalam organisasi bisnis dewasa ini, para pegawai didorong agar memiliki keterlekatan kerja yang baik dan terus menerus dipapar dengan budaya belajar yang intensif maka akan membangun ketangkasan belajar yang memadai.
Explainable Distance-based Outlier Detection in Data Streams

Explaining outliers is a topic that attracts a lot of interest; however existing proposals focus on the identification of the relevant dimensions. We extend this rationale for unsupervised distance-based outlier detection, and through investigating subspaces, we propose a novel labeling of outliers in a manner that is intuitive for the user and does not require any training at runtime. Moreover, our solution is applicable to online settings and a complete prototype for detecting and explaining outliers in data streams using massive parallelism has been implemented. Our solution is evaluated in terms of both the quality of the labels derived and the performance.
3rd Workshop for Young Scientists in Computer Science & Software Engineering

This is an introductory text to a collection of selected papers from the 3rd Workshop for Young Sci- entists in Computer Science & Software Engineering (CS&SE@SW 2020), which was held in Kryvyi Rih, Ukraine, on the November 27, 2020. It consists of short summaries of selected papers and some observations about the event and its future.
Multi-objective auto-scaling scheduling for micro-service workflows in hybrid clouds

ABSTRACT A novel multi-objective (cost, delay, and reliability) auto-scaling optimisation model is proposed for micro-service workflows in containerised hybrid clouds. We compare the container-based model with VM-based model and conclude that the former significantly supersedes. The benchmark of three mainstream algorithms is conducted by the Hypervolume metric, showed that the performance of MOEA/D is inferior to NSGA family, and NSGA-III is not always superior to NSGA-II. So we design an improved NSGA-II based on dynamically changing crossover and mutation operators, which outperforms NSGA-III both in stability and performance by over 60% and 80% in all multi-scale tests.
Estudo da germinação e morfologia do desenvolvimento pós-seminal de Syngonanthus mucugensis Giul. “in vitro”

Syngonanthus mucugensis (Eriocaulaceae) ocorre nos campos rupestres da Bahia. Sua importância econômica reside no uso em artesanatos das inflorescências e escapos. Isso confere a essa espécie alto valor comercial e o seu extrativismo constitui-se em uma importante atividade econômica nas regiões onde ocorre. A exploração tem sido feita de forma indiscriminada, o que expõe a espécie ao risco de extinção. O objetivo do presente trabalho foi avaliar as principais características da germinação e analisar a morfologia do desenvolvimento pós-seminal de S. mucugensis in vitro, visando fornecer subsídios para futuros trabalhos. Após assepsia e tratamento de embebição por 24 horas, as sementes foram colocadas para germinar em placas de Petri sob condições controladas no claro ou no escuro. Foram utilizadas 20 sementes em cada placa de Petri, contendo meio de cultura para germinação (7 g.L-1 de ágar), com pH 5,7 ajustado antes da autoclavagem (1 atm, 121 ºC e 15 min). Os resultados mostraram que sementes de S. mucugensis necessitam de luz para germinar, a germinação é do tipo hipógea com taxa superior a 85%, ocorrendo um embrião por semente. A primeira fase do desenvolvimento pósseminal inicia-se com a protrusão do eixo embrionário de onde se desenvolvem concomitantemente as folhas e as raízes. Aproximadamente 25 dias após a germinação, as plantas apresentaram comprimento médio de 10 mm, cerca de quatro folhas com tricomas malphighiáceos distribuídos pelas margens e um sistema radicular formado por duas raízes.
Long-term outcomes following drug-eluting balloon or thin-strut drug-eluting stents for treatment of in-stent restenosis stratified by duration of dual antiplatelet therapy (DEB-Dragon Registry)

Introduction Data regarding the duration of dual antiplatelet therapy (DAPT) in patients with drug-eluting stent restenosis (DES-ISR) treated with percutaneous coronary intervention (PCI) and drug-eluting balloons (DEB) or DES are not unambiguous. Aim To evaluate the relationship between long-term outcomes and the length of DAPT in patients treated with PCI due to DES-ISR with DEB or DES. Material and methods Overall, a total of 1,367 consecutive patients with DES-ISR, who underwent PCI with DEB or DES between 2008 and 2019 entered the study. The mean length of the follow-up was 1,298.7 ±794 days. We assessed study endpoints according to the duration of DAPT (≤ 3 vs. > 3 and ≤ 6 vs. > 6 months) before and after propensity score matching (PSM): stroke, target lesion revascularisation (TLR), target vessel revascularisation (TVR), myocardial infarction (MI), death and device oriented composite endpoints (DOCE). Kaplan-Meier estimates were created to differentiate long-term outcomes. Results Pairwise contrast analysis considering type of PCI (DES vs. DEB) and duration of DAPT (≤ 6 vs. > 6 months) before PSM revealed superiority of DES + DAPT > 6 months vs. DEB + DAPT > 6 months for DOCE (p < 0.001), TVR (p = 0.02) and TLR (p = 0.01). Also, DES + DAPT ≤ 6 months was found to be superior compared to DEB + DAPT ≤ 6 months for DOCE (p < 0.001), TVR (p = 0.02) and TLR (p = 0.01). Kaplan-Meier estimate analysis confirmed that DAPT > 6 months is related to a higher stroke rate (p = 0.01) when compared to ≤ 6 months. Conclusions Treatment with DAPT in patients with DES-ISR is related to better long-term outcomes in the case of PCI with DES than DEB. DAPT > 6 months is related to the greater rate of strokes, independently of the type of treatment (DES and DEB) than DAPT ≤ 6 months.
The physical and emotional health of South Korean mothers of preterm infants in the early postpartum period: a descriptive correlational study

Purpose This study investigated the physical and emotional health of South Korean mothers of preterm infants in the early postpartum period. Methods In this descriptive correlational study, the participants included 91 mothers of preterm infants who were admitted to the neonatal intensive care unit of a tertiary hospital in South Korea. Physical health status was measured using a self-reported questionnaire, postpartum depression using the Edinburgh Postnatal Depression Scale, anxiety using the State-Trait Anxiety Inventory, and guilt using a 4-item scale. Results Fatigue had the highest score among mothers' physical health problems, followed by shoulder pain, nipple pain, neck pain. The average postpartum depression score was 11.02 points, and 44% of women had postpartum depression with a score of 12 or above. Postpartum depression significantly was correlated with physical health (r=.35, p=.001), anxiety (r=.84, p<.001), and guilt (r=.75, p<.001) and was significantly higher for women with multiple births, and preterm infants who required ventilator and antibiotic treatment. Anxiety also showed a significant difference according to preterm infants’ condition. Conclusion The significant correlations between postpartum depression and physical health, anxiety, and guilt indicate a need for nursing interventions that provide integrated management of mothers’ physical and emotional health.
Solution of Linear Electrical Circuit Problem using Differential Transformation Method

In this paper, Differential Transformation Method DTM is introduced to study the singular system of a linear electrical circuit for time invariant and time varying cases. The discrete solutions obtained using DTM are compared with the exact solutions of the electrical circuit problem and are found to be very accurate and compatible. Graphs for inductor currents and capacitor voltages are presented to show the efficiency of DTM.
Software Project Management: Tools assessment, Comparison and suggestions for future development.

Software engineering is concerned with the development and advancement of huge and multiple software intensive systems. It shelters theories, methods and tools for the specification, architecture, design, testing, and maintenance of software systems. Today’s development of software systems are significantly large, complex and critical, that only through the use of automated approaches can such systems be developed and evolve in an economic and timely manner. While using automated software tools which is vital for successful planning and managing of projects. There are many automated software tools which have been developed for different purposes in different situation. The literature on how to select the appropriate software project management tools is fairly narrow. The identification of quality project management software among the existing tools in literature is critical. In this paper we predict which project management tools have a great quality and how this quality can be standardized in the futuristic development of project management software.
Feasibility and Acceptability of a Complex Telerehabilitation Intervention for Pediatric Acquired Brain Injury: The Child in Context Intervention (CICI)

The current study is a feasibility study of a randomized controlled trial (RCT): the Child in Context Intervention (CICI). The CICI study is an individualized, goal-oriented and home-based intervention conducted mainly through videoconference. It targets children with ongoing challenges (physical, cognitive, behavioral, social and/or psychological) after acquired brain injury (ABI) and their families at least one year post injury. The CICI feasibility study included six children aged 11–16 years with verified ABI-diagnosis, their families and their schools. The aim was to evaluate the feasibility of the intervention components, child and parent perceptions of usefulness and relevance of the intervention as well as the assessment protocol through a priori defined criteria. Overall, the families and therapists rated the intervention as feasible and acceptable, including the videoconference treatment delivery. However, the burden of assessment was too high. The SMART-goal approach was rated as useful, and goal attainment was high. The parents’ ratings of acceptability of the intervention were somewhat higher than the children’s. In conclusion, the CICI protocol proved feasible and acceptable to families, schools and therapists. The assessment burden was reduced, and adjustments in primary outcomes were made for the definitive RCT.
Rapid door-number recognition by a humanoid mobile robot

A static door-number recognition system for mobile robots in office buildings is presented. The motivation behind the development of such a system is to update the localization results of dead reckoning or improve other distance-sensor based localization. Emphasis is placed on minimizing the processing time of a template-matching based recognition method to enable real-time image-based localization for a mobile robot. A gap-based heuristic idea is put forward to increase the recognition accuracy. The experimental results show that door-numbers can be rapidly and robustly identified under different environmental conditions and postures of the camera.
A novel digital multi-mode control strategy with PSM for primary-side flyback converter

ABSTRACT This article described a novel digital multi-mode control strategy for primary-side controlled flyback converter to improve the efficiency within full-load range. The working modes of different load ranges were chosen according to the main power losses analysis and other constraint. Especially, a novel pulse skip mode control method which could reduce the number of actual switching cycles was proposed to improve the light load efficiency. A prototype with field-programmable gate array control has been made to verify the proposed digital multi-mode control strategy.
New weapons to fight malaria transmission: A historical view

The stagnation of our fight against malaria in recent years, mainly due to the development of mosquito insecticide resistance, argues for the urgent development of new weapons. The dramatic evolution of molecular tools in the last few decades led to a better understanding of parasite–mosquito interactions and coalesced in the development of novel tools namely, mosquito transgenesis and paratransgenesis. Here we provide a historical view of the development of these new tools and point to some remaining challenges for their implementation in the field.