Miracle-dz/UniFAR-FTUs huggingface dataset:
eview lliances against depression – A community based approach to target depression nd to prevent suicidal behaviour

Depressive disorders as well as fatal and non-fatal suicidal behaviour continue to be important mental health issues. Because of the close relation between depression and suicidal behaviour, it is likely that preventive actions improving care and optimising treatment for depressed patients result in a reduction of suicidal acts. This was shown in the Nuremberg Alliance against Depression, a two-year four-level community based intervention program associated with a 24% reduction of suicidal acts (completed and eywords: epression prevention uicide prevention our-level-intervention ulti-level intervention ommunity based intervention attempted suicides combined) compared to a baseline year and a control region. Serving as a model project, this approach has up to now been adopted in more than 100 regions in Germany and Europe. Within the suicide prevention project OSPI-Europe, the four-level-approach was optimized and further implemented and evaluated in different European regions. © 2013 Elsevier Ltd. All rights reserved. ntervention programs
Simple and efficient expression of codon-optimized mouse leukemia inhibitory factor in Escherichia coli

Purpose: To obtain a higher yield of mouse leukemia inhibitory factor to maintain the proliferation potential of pluripotent stem cells at a low cost. Methods: A method was designed to produce recombinant mLIF protein (rmLIF) in Escherichia coli . Through analysis of rmLIF sequence, it was found that rare codons were interspersed. After mutation from rare codons to Escherichia coli ( E. coli ) preferred ones were selected, the mutated gene mLIF m was cloned into pET15b vector. The pET15b-mLIF m was then transformed into Rosetta-gami strain and induced with optimal conditions at 18 o C for 16 h. Mass spectrometry was carried out to identify the peptides. Results: After purification, the yield of the codon-optimized rmLIF m was 141 mg/L, compared with 110 mg/L for the original rmLIF. Mass spectral analysis showed the presence of four major peptides each with an intensity > 10 % at m/z 1031.57, 1539.82, 1412.01 and 2229.10 in mLIF m , respectively. Histagged rmLIF m fusion protein displayed the potential to maintain the morphology of undifferentiated mouse embryonic stem cells (mESCs), which were positive for mESCs markers (Oct-4, Nanog, Sox-2, stage-specific embryonic antigen-1). Conclusion: The findings provide a means to produce mLIF in a short, useful, cost-effective and environmentally-friendly manner, and thus lays a foundation for further studies of mLIF. Keywords: Leukemia inhibitory factor, Mutated gene, Protein expression, Purification, Stem cells, Peptides, Escherichia coli
SUPPLY CHAIN INTEGRATION OF CONTAINER TERMINALS LOCATED IN AEGEAN REGION OF TURKEY *

In the new competitive environment of maritime business, a need for evaluating supply chain integration of ports has emerged. The aim of this paper is to evaluate the supply chain integration of three container terminals located in the Aegean Region of Turkey. We have developed a model consisting of four constructs: “relationship with users”, “information and communication systems”, “value added services” and “multimodal connections and systems”. We have also conducted a questionnaire through the shipping companies which use the container terminals and tested the validity by means of performing Confirmatory Factor Analysis. The results indicate the two privately owned container terminals are more closely integrated with the supply chain than the publicly owned container terminal. On the other hand, multimodal connections and systems of the two privately owned container terminals are less supply chain integrated than the publicly owned container terminals since the former lack adequate rail and road connections.
Jack the Reader – A Machine Reading Framework

Many Machine Reading and Natural Language Understanding tasks require reading supporting text in order to answer questions. For example, in Question Answering, the supporting text can be newswire or Wikipedia articles; in Natural Language Inference, premises can be seen as the supporting text and hypotheses as questions. Providing a set of useful primitives operating in a single framework of related tasks would allow for expressive modelling, and easier model comparison and replication. To that end, we present Jack the Reader (JACK), a framework for Machine Reading that allows for quick model prototyping by component reuse, evaluation of new models on existing datasets as well as integrating new datasets and applying them on a growing set of implemented baseline models. JACK is currently supporting (but not limited to) three tasks: Question Answering, Natural Language Inference, and Link Prediction. It is developed with the aim of increasing research efficiency and code reuse.
Ground Beetles on Islands: On the Effects of Habitat and Dispersal

Neutral theory focuses on random dispersal and species equivalence, and challenges views on the ecological importance of life history traits and habitat properties in explaining community assembly and the spatial distribution of species. Ground beetles are a popular model taxon to test predictions of contrasting macroecological theories. Here we investigate the effects of habitat properties and life history on the occurrence and community structure of 71 carabid beetle species inhabiting 15 lake islands in NE Poland. Island properties, particularly area and habitat quality, were positively linked to the occurrences of 42% of the species and correlated with species richness and &bgr;-diversity. Life history traits (hibernation type, dispersal ability and average abundances) significantly influenced species occurrences. Thus, site and species properties influence the spatial distribution of species and macroecological patterns on islands.
Validation of the Cincinnati Prehospital Stroke Scale

Background: Early recognition of Stroke is one of the key concepts in the “Chain of Survival” as described by the American Heart Association/American Stroke Association Stroke guidelines. The most commonly used tools for prehospital assessment of stroke are “The Cincinnati Prehospital Stroke Scale,” (CPSS) the “Face, Arm, Speech Test,” and “The Los Angeles Prehospital Stroke Screen. ” The former two are used to identify stroke using physical findings while the latter is used to rule out other causes of altered consciousness. Aim: The aim of this study is to validate the CPSS in the prehospital setting by correlating with computed tomography scan findings. (1) To determine if these scores can be implemented in the Indian prehospital setting. (2) To determine if it is feasible for new emergency departments (EDs) to use these protocols for early detection of stroke. Methodology: A prospective, observational study from December, 2015 to March, 2016. Patients with suspected stroke were enrolled. Data were collected prehospital in patients that arrived to the ED in an ambulance. Sensitivity, specificity, positive predictive value, and negative predictive value of the score were calculated using standard formulae. Results: CPSS showed good sensitivity of 81% (confidence interval [CI] – 68.5%–97%) when combined and a positive predictive value (PPV) of 100% (CI: 91.9%–100%). Individually, they showed a sensitivity of 75.8%, 79%, and 74.1%, respectively, with a PPV of 100% and specificity of 95%–100%. Conclusion: As a prehospital screening tool, CPSS can be extremely useful as any diagnosis is only provisional until confirmed by an appropriate investigation in a hospital.
Evidence of Population Genetic Structure within the Florida Worm Lizard, Rhineura floridana (Amphisbaenia: Rhineuridae)

Abstract The Florida Worm Lizard (Rhineura floridana) is the only extant representative of the suborder Amphisbaenia occurring in the United States and the only living representative of the Rhineuridae. We updated the known distribution of this species from 510 records with known localities. We further examined geographic genetic structure within this species using 1360 bp of mitochondrial DNA sequence data from 18 samples of R. floridana. Our results suggest an ancient divergence between populations in the north-central Florida peninsula from populations in the south-central peninsula. High genetic distances are observed within south-central populations, whereas genetic structure within northern populations is less discrete and characterized by much shallower divergences. Our findings suggest that south-central populations may be candidates for taxonomic recognition (or recognition as distinct management units) if additional genetic and morphological data support our results.
Phase mixing of Alfven waves in axisymmetric non-reflective magnetic ´ plasma configurations

We study damping of phase-mixed Alfvén waves propagating in non-reflective axisymmetric magnetic plasma configurations. We derive the general equation describing the attenuation of the Alfvén wave amplitude. Then we applied the general theory to a particular case with the exponentially divergent magnetic field lines. The condition that the configuration is nonreflective determines the variation of the plasma density along the magnetic field lines. The density profiles exponentially decreasing with the height are not among non-reflective density profiles. However, we managed to find non-reflective profiles that fairly well approximate exponentially decreasing density. We calculate the variation of the total wave energy flux with the height for various values of shear viscosity. We found that to have a substantial amount of wave energy dissipated at the lower corona, one needs to increase shear viscosity by seven orders of magnitude in comparison with the value given by the classical plasma theory. An important result that we obtained is that the efficiency of the wave damping strongly depends on the density variation with the height. The stronger the density decrease, the weaker the wave damping is. On the basis of this result, we suggested a physical explanation of the phenomenon of the enhanced wave damping in equilibrium configurations with exponentially diverging magnetic field lines.
Enhancer RNAs (eRNAs): New Insights into Gene Transcription and Disease Treatment

Enhancers are cis-acting elements that have the ability to increase the expression of target genes. Recent studies have shown that enhancers can act as transcriptional units for the production of enhancer RNAs (eRNAs), which are hallmarks of activity enhancers and are involved in the regulation of gene transcription. The in-depth study of eRNAs is of great significance for us to better understand enhancer function and transcriptional regulation in various diseases. Therefore, eRNAs may be a potential therapeutic target for diseases. Here, we review the current knowledge of the characteristics of eRNAs, the molecular mechanisms of eRNAs action, as well as diseases related to dysregulation of eRNAs.
Unraveling large scale geographical distribution of vulnerable DNS servers using asynchronous I / O mechanism

The Domain Name System (DNS) has become one of the most important infrastructures of Internet. Despite of its importance, we are not able to comprehensive view of the situation of deployment of DNS servers in real-world and therefore assess the security level according to the monitoring results. In this paper we present some results of analyzing DNS server deployment over Internet fine-grained information of software versions, geographical locations. In experiment, we have succeeded to gather information of 10,334,293 DNS servers over the world in 24 by leveraging asynchronous event notification library. For high-speed active monitoring, we adopt Libevent which provides asynchronous I/O mechanisms and MongoDB which is fast and scalable NoSQL cluster software. From monitoring results, we show some findings which should be considered for security assessment for DNS deployment over Internet. Surprisingly, more than 1000 DNS servers employ the oldest version of BIND 4.x which could be easily compromised by malicious hosts. Besides, we show in-depth study of geographical distribution of vulnerable DNS servers which can provides comprehensive view of security level of each country. It is turned out that even advanced IT countries achieving high-security level has ” weakest link” exposed by fine-grained active monitoring, which means these countries actually have serious vulnerabilities concerning IT infrastructure. In addition, it is shown that large scale active monitoring of DNS servers have been easily achieved within only several hours.
Factors Associated with Poor Sleep Quality among Type 2 Diabetes Mellitus Patients on Insulin Therapy

The aim of this study is to investigate the possible risk factors of poor sleep quality among patients with type 2 diabetes mellitus on insulin therapy. The factors considered were age, sex, body mass index (BMI), glycosylated haemoglobin (HbA1c), duration of diabetes and depression. A total of 202 diabetic patients aged 20 years or older were included in the study. The results showed that female sex and depression were independent risk factors for poor sleep quality among type 2 diabetics on insulin therapy. Findings may contribute to sleep disorder control in female patients with type 2 diabetes mellitus which has been linked to glycemic control.
Novel method of Kirschner wire bending for treatment of displaced patella fractures

Displaced patella fractures require operative treatment. Tension band wiring is the most common technique for the fixation such fractures; however, the procedure is often complicated by wire migration. Herein, we described a novel method of Kirschner wire (K-wire) bending during tension band wiring that may help to prevent wire migration. In our five-step method, two K-wires inserted into the patella were bent and cut to form hooked ends, which could be pushed against the superior border of the patella to serve as an anchor to hold the tension band in place, thus preventing its migration. Using this technique, we had managed over 20 patients in our department over a period of 3 years, without any complications.
Possession identification in text

Abstract Just as industrialization matured from mass production to customization and personalization, so has the Web migrated from generic content to public disclosures of one’s most intimately held thoughts, opinions, and beliefs. This relatively new type of data is able to represent finer and more narrowly defined demographic slices. If until now researchers have primarily focused on leveraging personalized content to identify latent information such as gender, nationality, location, or age, this article seeks to establish a structured way of extracting possessions, or items that people own or are entitled to, as a way to ultimately provide insights into people’s behaviors and characteristics. We introduce the new task of ‘possession identification in text’, and release a novel dataset where possessions are marked at different confidence levels. We present experiments and results obtained when seeking to automatically identify and extract possessions from the text.
Neoadjuvant chemotherapy in breast cancer: a dose-dense schedule in real life and putative role of PIK3CA mutations

Background Dose-dense chemotherapy is one of the treatments of choice for neoadjuvant therapy in breast cancer (BC). Activating mutations in PIK3CA gene predict worse response to neoadjuvant chemotherapy for HER2-positive patients, while their role is less clearly defined for HER2-negative tumors. Methods We conducted a phase I/II study of neoadjuvant, sequential, dose-dense anthracycline/taxane chemotherapy, plus trastuzumab in HER2-positive patients and investigated the correlation of pre-treatment PIK3CA mutation status with pathologic complete response (pCR) and long-term outcome in a real-life setting. Results we established a dose-dense docetaxel recommended dose of 60 mg/m2 and 65 mg/m2, with or without trastuzumab, respectively, according to HER2-status, following dose-dense epirubicin-cyclophosphamide (90/600 mg/m2), every 2 weeks. The overall pCR rate was 21.4%; median disease-free survival (DFS) was 52 months and median overall survival (OS) was not yet reached. PIK3CA mutation status was not significantly associated with the pCR rate: 18% for both mutated and wild-type patients. The pCR rate was: 25% in the mutated and 24% in the wild-type (p 0.560) cohort of the HER2-positive subgroup; 33% both in the mutant and wild-type cohort of the triple-negative subgroup; no pCR neither in the mutant nor in the wild-type cohort of the HR-positive/HER2-negative subgroup. Among the HER2-positive population, a trend toward worse DFS was observed in case of mutation, as opposed to the triple negative population. Conclusions This study proposes an effective and safe neoadjuvant dose-dense anthracycline/taxane schedule and suggests that PIK3CA mutation analysis can be usefully performed in real-life clinical practice.
The genetic network of greater sage‐grouse: Range‐wide identification of keystone hubs of connectivity

Abstract Genetic networks can characterize complex genetic relationships among groups of individuals, which can be used to rank nodes most important to the overall connectivity of the system. Ranking allows scarce resources to be guided toward nodes integral to connectivity. The greater sage‐grouse (Centrocercus urophasianus) is a species of conservation concern that breeds on spatially discrete leks that must remain connected by genetic exchange for population persistence. We genotyped 5,950 individuals from 1,200 greater sage‐grouse leks distributed across the entire species’ geographic range. We found a small‐world network composed of 458 nodes connected by 14,481 edges. This network was composed of hubs—that is, nodes facilitating gene flow across the network—and spokes—that is, nodes where connectivity is served by hubs. It is within these hubs that the greatest genetic diversity was housed. Using indices of network centrality, we identified hub nodes of greatest conservation importance. We also identified keystone nodes with elevated centrality despite low local population size. Hub and keystone nodes were found across the entire species’ contiguous range, although nodes with elevated importance to network‐wide connectivity were found more central: especially in northeastern, central, and southwestern Wyoming and eastern Idaho. Nodes among which genes are most readily exchanged were mostly located in Montana and northern Wyoming, as well as Utah and eastern Nevada. The loss of hub or keystone nodes could lead to the disintegration of the network into smaller, isolated subnetworks. Protecting both hub nodes and keystone nodes will conserve genetic diversity and should maintain network connections to ensure a resilient and viable population over time. Our analysis shows that network models can be used to model gene flow, offering insights into its pattern and process, with application to prioritizing landscapes for conservation.
The Multifaceted Self Effect: Flexibility or Merely Self-Enhancement? ☆ ☆☆

Abstract Previous research has shown that people ascribe more traits to themselves than to others, and more traits to liked others than to disliked others, suggesting that the self and liked others are viewed as “multifaceted. ” A limitation of those studies was their use of generally desirable traits. The present studies asked subjects to describe themselves and liked and disliked well-known others and acquaintances on trait pairs spanning the full range of social desirability. The results for desirable traits replicated previous studies, but the results for undesirable traits did not. Subjects judged themselves to have the same number of undesirable traits as others and judged liked others to have fewer undesirable traits than disliked others. Nondepressed subjects showed these biases to enhance the self and liked others to a greater degree than did depressed subjects.
Dynamic adaptive streaming for multi-viewpoint omnidirectional videos

Full immersion inside a Virtual Reality (VR) scene requires six Degrees of Freedom (6DoF) applications where the user is allowed to perform translational and rotational movements within the virtual space. The implementation of 6DoF applications is however still an open question. In this paper we study a multi-viewpoint (MVP) 360-degree video streaming system, where a scene is simultaneously captured by multiple omnidirectional video cameras. The user can only switch positions to predefined viewpoints (VPs). We focus on the new challenges that are introduced by adaptive MVP 360-degree video streaming. We introduce several options for video encoding with existing technologies, such as High Efficiency Video Coding (HEVC) and for the implementation of VP switching. We model three video-segment download strategies for an adaptive streaming client into Mixed Integer Linear Programming (MILP) problems: an omniscient download scheduler; one where the client proactively downloads all VPs to guarantee fast VP switch; one where the client reacts to the user's navigation pattern. We recorded a one MVP 360-degree video with three VPs, implemented a mobile MVP 360-degree video player, and recorded the viewing patterns of multiple users navigating the content. We solved the adaptive streaming optimization problems on this video considering the collected navigation traces. The results emphasize the gains obtained by using tiles in terms of objective quality of the delivered content. They also emphasize the importance of performing further study on VP switching prediction to reduce the bandwidth consumption and to measure the impact of VP switching delay on the subjective Quality of Experience (QoE).
Occurrence of Root Rot of Panax notoginseng Caused by Fusarium oxysporum in China

A root rot disease was found in P. notoginseng plantations based in Guizhou province in 2015 and 2016. This disease affected mainly P. notoginseng rhizomes and leaves, causing oval or irregular spots, finally resulting in the infected plants withering and dying. We collected twenty-five infected rhizome samples of P. notoginseng from Guizhou province. The pathogen was identified as Fusarium oxysporum based on the morphology and molecular characterization including rDNA ITS, and EF sequence analysis, High throughput sequencing and Maximum Parsimony of the pathogen was conducted. In addition, we investigated the occurrence and frequency of P. notoginseng root rot in Guizhou province, and found that temperature and humidity were the main factors influencing P. notoginseng root rot. In addition, high light levels and lack of crop rotation were also associated with the occurrence of P. notoginseng root rot. © 2018 Friends Science Publishers