Miracle-dz/UniFAR-FTUs huggingface dataset:
Preserving Security in Routing in Mobile Ad-hoc Environment through Non-Linear Dimension Reduction Techniques

- A mobile Ad-Hoc Network (MANET) is a collection of wireless nodes that communicate with each other without any infrastructure. Present day mobile ad hoc networks grow in size and the associated complexity warrant the need to explore the suitability of the various simulation parameters during their execution. One of the major issues related to the MANET is security of data that has been transferred via wireless communication medium. In this paper we conclude that dimension reduction is one of the factors through we can achieve the security and maintain the integrity of dataset. We highlight various Non-Linear dimension reduction techniques which applied on common MANET parameters.
Survey on Machine learning Techniques used for Information Security

: Today Machine learning algorithms are the driving force of many applications because of their adjustable and expandable characteristics. They are influencing almost every aspect of the research. Information security one of the evolving fields in research. Data is being generated by heterogeneous sources, which provides a great scope for the information security research and machine learning algorithms can play a vital role for this. This paper provides a literature review for information security threats and the effects of machine learning algorithms against these threats.
Partial Laminate Veneers for a Maxillary Midline Diastema Closure: A Case Report

Background: A variety of approaches can be employed to close diastemas using conservative and non-conservative restorative techniques such as composite restorations, laminate veneers, and crowning if there is no indication for orthodontic treatment. Objectives: This paper aimed to discuss the mechanical properties of sectional laminate veneers, the preparation, and the ceramic material used for their manufacturing. Material and methods: A case of a maxillary midline diastema closure using feldspathic partial laminate veneers with an ultra-conservative preparation is described. Results: Feldspathic sectional laminate veneers achieve an esthetically pleasant diastema closure. The ultra-conservative preparation and adequate polishing technique preserve dental and gingival tissues. Conclusion: It can be concluded that sectional partial veneers are an esthetic option with low mechanical properties that must be carefully indicated.
The PEP-II project: Design status and R&D results

The PEP-II project, a joint proposal of SLAC, LBL, and LLNL, will involve an upgrade of the PEP storage ring at SLAC to serve as an asymmetric B factory. The upgrade will involve replacing the vacuum and rf systems of PEP, which will serve as the high-energy ring (containing 9 GeV electrons), along with the addition of a new low-energy ring (containing 3.1 GeV positrons) mounted atop the high-energy ring. The present design status of the project and a summary of recent R&D results are presented here. If approved, the PEP-II project is ready to begin construction in October 1993.
Pipersentan: A De Novo Synthetic Endothelin Receptor Antagonist that Inhibits Monocrotaline- and Hypoxia-Induced Pulmonary Hypertension

Background: Although major advances have been made in the pathogenesis and management of pulmonary arterial hypertension (PAH), the endothelin system is still considered to play a vital role in the pathology of PAH due to its vasoconstrictive action. Endothelin receptor antagonists (ERAs), either as monotherapy or in combination with other drugs, have attracted much attention in the treatment of this lethal disease, and research is continuing. Methods: A novel ERA, pipersentan 5-(1,3-Benzodioxol-5-yl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(2-methoxyethylsulfamoyl)pyrimidin-4-amine, was recently synthesized and the physicochemical characterizations and the pharmacology both in vitro and in vivo were studied. Results: This orally administered ERA can both competitively and selectively inhibit the binding of endothelin-1 (ET-1) to its receptors with good physicochemical characteristics. Pipersentan efficaciously antagonized the effects of ET-1 on pulmonary artery smooth muscle cell proliferation, migration and calcium mobilization and effectively improved right ventricular hypertrophy and pulmonary arterial pressure in both monocrotaline- and hypoxia-induced pulmonary hypertension (PH) rat models. Conclusions: This profile identifies pipersentan as a new agent for treating ET-1 system activation-related PH.
Effectiveness of Video-discharge Instructions about Colostomy Self-care on Awareness and Self-efficacy of Low-Literacy Patients

Background: Low literacy patients need new methods to improve their awareness and enhance selfefficacy regarding problems related to the colostomy care. Aim: To evaluate effectiveness of video-discharge instructions about colostomy selfcare on awareness and self-efficacy of low-literacy patients. Research design: Quasi-experimental study design (pre–post test). Setting: The study was carried out in the General Surgical Department and Outpatient Clinic at Assiut University Hospital Subjects: Purposive thirty low-literacy patients with colostomy. Tools: (I) Patients' awareness questionnaire which included demographic and medical data of the patients and Pre – post stomarelated awareness and (II): Stoma self Efficacy Scale. Result: Majority of the studied patients were males their ages more than 40 years old and not work (76.7%, 66.6% and 66.7% respectively). Half (50%) of them diagnosed with cancer colon. A significant statistically difference was found regarding total awareness, and selfefficacy scores of the studied patients between pre and post implementation of the videodischarge instructions with a positive correlation among them. Conclusion: That implementation of video-discharge instructions about colostomy self-care had a positive effect on awareness and self-efficacy of low literacy patient. Recommendation: For managing every aspects of stoma care should be a top priority, preferably before leaving the hospital. For low literacy patients who should be included in hospital programs provided by ostomy care team for improving their awareness, self-efficacy, prevention and treatment of their complications.
A Novel Method for Baroreflex Sensitivity Estimation Using Modulated Gaussian Filter

The evaluation of baroreflex sensitivity (BRS) has proven to be critical for medical applications. The use of α indices by spectral methods has been the most popular approach to BRS estimation. Recently, an algorithm termed Gaussian average filtering decomposition (GAFD) has been proposed to serve the same purpose. GAFD adopts a three-layer tree structure similar to wavelet decomposition but is only constructed by Gaussian windows in different cutoff frequency. Its computation is more efficient than that of conventional spectral methods, and there is no need to specify any parameter. This research presents a novel approach, referred to as modulated Gaussian filter (modGauss) for BRS estimation. It has a more simplified structure than GAFD using only two bandpass filters of dedicated passbands, so that the three-level structure in GAFD is avoided. This strategy makes modGauss more efficient than GAFD in computation, while the advantages of GAFD are preserved. Both GAFD and modGauss are conducted extensively in the time domain, yet can achieve similar results to conventional spectral methods. In computational simulations, the EuroBavar dataset was used to assess the performance of the novel algorithm. The BRS values were calculated by four other methods (three spectral approaches and GAFD) for performance comparison. From a comparison using the Wilcoxon rank sum test, it was found that there was no statistically significant dissimilarity; instead, very good agreement using the intraclass correlation coefficient (ICC) was observed. The modGauss algorithm was also found to be the fastest in computation time and suitable for the long-term estimation of BRS. The novel algorithm, as described in this report, can be applied in medical equipment for real-time estimation of BRS in clinical settings.
Green space accessibility in Europe: a comparative study of five major cities

ABSTRACT In the current era of climate breakdown, access to green space is not optional – it is vital. This study investigates the current disparities in urban green space access in five medium-sized European cities: Birmingham, Brussels, Milan, Prague and Stockholm. Through a GIS-based network analysis, we explore whether disparities in urban green space access (1) relate to income inequalities within cities and/or (2) are based on a city’s regional location within Europe. We find that Prague presents the highest green space accessibility, followed by Stockholm, Brussels, Birmingham, and finally Milan. Higher-income residents have more access to green space in Brussels, Milan, Prague, and Stockholm. In Birmingham, however, lower-income neighbourhoods presented higher green accessibility. Urban green spaces were distributed differently across the various European regions, each of which has a unique history and planning culture. Urban planners are challenged to redress these disparities – while considering the unique environmental, economic, social, and cultural dimensions of each place.
Combination of the NRF2 Inhibitor and Autophagy Inhibitor Significantly Inhibited Tumorigenicity of Castration-Resistant Prostate Cancer

Prostate cancer (PCa) is the most frequent cancer in men. Developing new treatment methods for CRPC will be a significant challenge in the clinical treatment of PCa. In conclusion, the results of this study show that NRF2 is downregulated in untreated PCa samples compared to normal PCa samples; however, it was upregulated in mCRPC samples compared to HSPC samples. These results demonstrated that NRF2 may serve as a tumor suppressor in tumorigenesis but promote PCa androgen-independent transferring after ADT treatment. Bioinformatics analysis showed that NRF2 was related to multiple signaling, such as the AGE-RAGE pathway, MAPK pathway, NF-kappa B signaling, PI3K-Akt signaling pathway, and VEGF signaling pathway. Moreover, we revealed that the NRF2 inhibitor significantly inhibited tumorigenicity of CRPC cells in vitro. Of note, combination of the NRF2 inhibitor and autophagy inhibitor had a more significantly suppressive role than either ML385 or CQ, indicating that combination of CQ (autophagy inhibitor) and ML385 (NRF2 inhibitor) is a potential treatment of CRPC. Finally, we conformed that high levels of autophagy regulators LC3B, ULK1, and beclin1 significantly correlated to longer PSA recurrence-free survival time. We think that this study could provide more evidence to confirm that NRF2 is a crucial regulator and targeting NRF2 and autophagy is a potential therapy option for CRPC.
CTCF-FOXM1 axis regulates tumor growth and metastasis in hepatocellular carcinoma

CCCTC-binding factor (CTCF) is a DNA-binding protein that interacts with a large number of highly divergent target sequences throughout the genome. It is implicated in a variety of functions, including chromatin organization and transcriptional control. The functional role of CTCF in tumor pathogenesis remains elusive. We showed that CTCF is frequently upregulated in a subset of primary hepatocellular carcinoma (HCC) compared with non-tumoral liver. Overexpression of CTCF was associated with shorter disease-free survival of patients. Short hairpin RNA-mediated suppression of CTCF inhibited cell proliferation, motility and invasiveness in HCC cell lines; effects that were correlated with prominent reductions in the expression of telomerase reverse transcriptase (TERT), shelterin complex member (TRF1), and forkhead box protein M1 (FOXM1), whereas upregulation of CTCF was positively correlated with FOXM1 and TERT expression in clinical HCC biopsies. Depletion of CTCF resulted in reduced motility and invasiveness in HCC cells that could be reversed by ectopic expression of FOXM1, suggesting that FOXM1 is one of the important downstream effectors of CTCF in HCC. Reporter gene analysis suggested that depletion of CTCF is associated with reduced FOXM1 and TERT promoter activity. Chromatin immunoprecipitation (ChIP)-PCR analysis further revealed occupancy of the FOXM1 promoter by CTCF in vivo. Importantly, depletion of CTCF by shRNA significantly inhibited tumor progression and metastasis in HCC mouse models. Our work uncovered a novel functional role of CTCF in HCC pathogenesis, which suggests that targeting CTCF could be further explored as a potential therapeutic strategy for HCC.
Enabling the Existing Point-to-Point VSC-HVDC Control for Multi-Terminal Operation

Existing point-to-point (PtP) VSC-HVDC link's control is usually not prepared for a multi-terminal HVDC (MTDC) operation, e.g. the DC voltage droop control might not exist in the PtP link or active power control might not exist in the offshore wind farm (OWF) link. Therefore, an existing PtP link's converter control needs to be adjusted when this link is expanded into an MTDC system by interconnecting new converters into the existing system. If only one vendor is involved in the MTDC system, these MTDC specific controls can be applied directly since the vendor has the knowledge of the installed system. However, if several converter vendors are involved, they need to define a common requirement and adjust their converters to fulfil this requirement. Another option is to implement the MTDC specific control as an extension of the existing converter control. The converter control is operated in DC voltage control, which is commonly found in every PtP link, and the extension gives the appropriate DC voltage reference such that the converter operating point lies along a predefined characteristic. Simulation results show that both implementation approaches can be adopted when a PtP link is expanded into an MTDC system, although each of them has different advantages.
Urban water security - what does it mean?

ABSTRACT This research is focussed on understanding what urban water security means – a surprisingly elusive concept given the global shift from rural to urban living. We first make the case for a distinct urban water security definition. We then identify 25 unique water security definitions, of which three relate to the urban context but all with scope for improvement. Applying novel indices, we assess the prevalence, complexity and evolution of themes and dimensions within all definitions and find a stable spectrum of themes; but note a shifting emphasis towards environmental and social dimensions, away from quality and quantity of supply. Overall the definitions are becoming more comprehensive by simply listing more outcomes to be achieved. Instead of this ‘shopping-list’ approach, we propose a simplified urban water security definition with a focus on agreement of needs with community stakeholders, while using the themes to guide what the objectives might be.
Fully Decentralized P2P Energy Trading in Active Distribution Networks With Voltage Regulation

Peer-to-peer energy trading in an active distribution network can contribute to benefit sharing among multiple prosumers and efficient accommodation of distributed renewable energy. Nevertheless, the distribution voltage constraints should be satisfied such that the energy transactions can be securely implemented in the physical system. To this end, this paper develops a fully decentralized dual-loop peer-to-peer energy trading mechanism with voltage regulation capability. In the inner-loop process, the self-interested energy prosumers iteratively achieve optimal energy trading via multi-bilateral negotiation without considering network constraints. Then, the prosumers coordinatedly optimize their reactive power in a decentralized way endeavoring to satisfy the voltage constraints. If no physically feasible solution is detected, an outer-loop iterative process is activated, where the over-/under-voltage prosumers autonomously adjust their trading quantities to clear the voltage problem. Various case studies are performed in the standard IEEE 33-bus and IEEE 69-bus test feeders involving multiple energy prosumers to validate the effectiveness and efficiency of the proposed scheme.
The Effect of Remote-work Attitude on Life Satisfaction: Investigating the Mediating Role of Job Satisfaction

The Covid-19 pandemic emerged amid the transformations created by technological advances in working life and has led to the peak of remote and hybrid working settings worldwide. The present study aims to focus on the mediating role of job satisfaction regarding the relation between remote working and life satisfaction. The sample of the study consists of 415 white-collar workers living in different regions of Turkey, with at least an undergraduate degree, and has remote-working experience during the Covid-19 pandemic. SmartPLS 3 package program was used in the analysis of the data. As a result, we found that only skill development and organizational support dimensions of the remote working attitude affect job and life satisfaction. Also, we found that job satisfaction has a partial mediating role between skill development and life satisfaction. However, in the case of the relationship between organizational support and life satisfaction, job satisfaction emerged as a full mediator.
Integration Time and Time-Bin Width in Ranging Histograms for a Photon-Counting LiDAR

High-performance light detection and ranging (LiDAR) modules are highly demanded for advanced driving assistance system and autonomous driving. With CMOS-fabricated single-photon avalanche diodes (SPADs) and pulsed-operated semiconductor lasers, photon-counting based vehicle LiDARs are one of the most promising candidates for low-cost solution. The high data rate and the long integration time of SPAD LiDARs are two of main obstacles for realizing commercially affordable 3-D imagers. In this work, we develop an evaluation method for the minimum ranging time and investigate the time-bin width effect on the ranging precision. A simple formula for predicting the shortest integration time is proposed and compared with the experimental data. We also demonstrate that a proper time-bin width can reduce the data rate and required memory size without degrading the distance resolution. Our work paves the way for making low-cost vehicle LiDARs through system optimizing and engineering.
Pharmacological Modulation of Melanocortin 1 Receptor Signaling by Mrap Proteins in Xenopus tropicalis

The melanocortin system consists of five G protein–coupled receptors (MC1R-MC5R), the bidirectional endogenous ligands (MSH and Agouti families), and accessory proteins (MRAP1 and MRAP2). Accumulative studies of vertebrate species find high expression level of melanocortin 1 receptor (MC1R) in the dermal melanocyte and elucidate the essential roles in the skin and fur pigmentation, morphological background adaptation, and stress response. The diploid amphibian Xenopus tropicalis (xt) has been utilized as a fantastic animal model for embryonic development and studies of physiological cryptic colouring and environmental adaptiveness. However, the interaction of xtMc1r signaling with xtMrap proteins has not been assessed yet. In this study, we carried out in silico evolutionary analysis of protein alignment and genetic phylogenetic and genomic synteny of mc1r among various vertebrates. Ubiquitous expression of mrap1 and mrap2 and the co-expression with mc1r transcripts in the skin were clearly observed. Co-immunoprecipitation (ip) and fluorescent complementary approach validated the direct functional interaction of xtMc1r with xtMrap1 or xtMrap2 proteins on the plasma membrane. Pharmacological assay showed the improvement of the constitutive activity and alpha melanocyte-stimulating hormone (α-MSH) stimulated plateau without dramatic alteration of the cell surface translocation of xtMc1r in the presence of xtMrap proteins. Overall, the pharmacological modulation of xtMc1r by dual xtMrap2 proteins elucidated the potential role of this protein complex in the regulation of proper dermal function in amphibian species.
Diagnosis of Basin Eco-Hydrological Variation Based on Index Sensitivity of Similar Years: A Case Study in the Hanjiang River Basin

The variation of hydrological conditions in the basin affects the original stable state of the basin, and the change of eco-hydrological conditions also plays a decisive role in the stability of the basin. In this manuscript, Indicators of Hydrologic Alteration (IHA) was used to diagnose watershed variation from the eco-hydrological perspective, and a new diagnostic method was proposed in the current study, which was the extraction method of the most relevant eco-hydrological indicators based on a similar year sensitive index and the diagnosis method of variation period. This method used the sensitivity of statistical characteristics between similar years to provide the basis for the selection of the most ecologically-relevant hydrogeological indicators (ERHIs), then selected the strong variation indicators from the most relevant eco-hydrological indicators, and finally used the strong variation indicators to diagnose the watershed variation. The runoff data (1960 to 2020) in the Ankang gauging station of the Hanjiang River were analyzed, and the results showed that the indicators of high variation were the average duration index of low discharge in a year and the minimum discharge index of one day in a year. The variation period was from 1973 to 1986. It was concluded that the diagnosis results from the perspective of eco-hydrology were consistent with the actual hydrological situation changes, and this method had certain reliability.
Information systems for supply chain management: a systematic literature analysis

Information systems (IS) impact supply chain management (SCM) on processes such as planning, sourcing, and delivering, and at levels ranging from tactical operations to organisational strategy. The vast scope of IS and SCM relationships have resulted in diverse and disintegrated research on the topic. This paper offers a systematic literature analysis at the intersection of supply chain and information systems (SCIS), aiming to provide a classification for existing areas of research. This research is based on an analysis of more than 1500 articles published in peer-reviewed journals over the past four decades to classify topics and methods and to identify major trends and distinguish important research themes. The classification of the literature has identified major clusters of research in SCIS, and suggestions are made for future research in each of the identified clusters. In general, the findings point out that there is a dearth of research on topics such as ‘impact of IT on vertical disintegration of supply chains,’ ‘implications of new technologies for supply chains,’ and ‘concerns related to trust, governance, ownership, privacy, and security of data in supply chains. ’ This work provides both researchers and practitioners with an insightful description of the current state of research in SCIS and related future trends in research and practice.
Influence of relative thickness on multiferroic properties of bilayered Pb(Zr0.52Ti0.48)O3–CoFe2O4 thin films

Multiferroic bilayered thin films consisting of Pb(Zr0.52Ti0.48)O3 (PZT) and CoFe2O4 (CFO) layers of different relative thicknesses were prepared on a general Pt/Ti/SiO2/Si substrate via a simple solution processing. The influence of the thickness fraction on their properties including ferroelectric, ferromagnetic, and magnetoelectric properties in the PZT-CFO bilayered thin films was investigated. Our results showed that the thickness fractions (or relative thicknesses) of the layers have a significant effect not only on the magnetic and electric properties of the bilayered films but also on their magnetoelectric response. The bilayered thin films with the intermediate thickness fraction of around 0.6 exhibited a maximum magnetoelectric effect.