Miracle-dz/UniFAR-FTUs huggingface dataset:
Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma

Abstract Glioblastoma (GBM) is the most common and aggressive intrinsic brain tumour in adults. Epigenetic mechanisms controlling normal brain development are often dysregulated in GBM. Among these, BMI1, a structural component of the Polycomb Repressive Complex 1 (PRC1), which promotes the H2AK119ub catalytic activity of Ring1B, is upregulated in GBM and its tumorigenic role has been shown in vitro and in vivo. Here, we have used protein and chromatin immunoprecipitation followed by mass spectrometry (MS) analysis to elucidate the protein composition of PRC1 in GBM and transcriptional silencing of defining interactors in primary patient-derived GIC lines to assess their functional impact on GBM biology. We identify novel regulatory functions in mRNA splicing and cholesterol transport which could represent novel targetable mechanisms in GBM.
Related-Party Transactions, Chaebol Affiliations, and the Value of Cash Holdings

This study examines whether related-party transactions (RPTs) impact the value of firms’ cash holdings. Using a 2011–2018 sample of Korean public firms, we find that greater RPTs lead to lower cash holdings value. In particular, this decline is more pronounced in Korean chaebol firms than in non-chaebol firms. Our findings suggest that a unique and complex corporate governance structure of chaebol firms makes it difficult for outside investors to monitor firms’ internal cash management decisions, resulting in a negative valuation of cash holdings. This study contributes to the extant literature by providing additional evidence that RPTs in chaebol firms with severe agency problems may lower the value of cash holdings.
Pathogen reduction of platelets: experience of a single blood bank

: Pathogen reduction technology (PRT) has the potential to prevent pathogen transfusion transmission from blood donor to patient by impeding the replication of bacteria, viruses and parasites in blood components. Additionally, PRT can help to guarantee blood safety in challenging situations for blood supply, as in the Ebola or Chikungunya epidemics, or in a scenario full of uncertainties such as the current SARS-CoV-2 pandemic. The Balearic Islands Blood Bank (BIBB) is one of the few blood establishments worldwide with more than 10 years of experience in the routine use of amotosalen/UVA (Intercept Blood System) and riboflavin/UVA-UVB (Mirasol PRT system) for platelets (PLTs), the use of riboflavin/UVA-UVB for plasma and with research experience in riboflavin/UVA-UVB applied to whole blood. Over the years, we have had the opportunity to evaluate PRT from different perspectives, such as clinical and hemovigilance research in adults and children, in vitro studies on PRT effects on PLTs and assessing the financial impact of PRT implementation. PRT methods offer remarkable benefits but also have certain limitations, which are important to bear in mind during the decision-making process for PRT implementation. The purpose of this study is to review the current knowledge on PRT for PLTs drawing on our experience acquired over the last decade.
The clinical and functional outcome of arthroscopic bankart repair in recurrent shoulder dislocation

Background: Study aimed to assess the functional and clinical outcome of arthroscopic bankart’s repair in recurrent shoulder dislocation using UCLA & SST scoring system.Methods: It is a prospective cohort study conducted on the 28 patients undergoing arthroscopic bankart’s repair for recurrent shoulder dislocation in the department of orthopaedics at vydehi institute of medical sciences and research centre, bengaluru from September 2017 to October 2019. Patients aged between 18-50 years of both genders undergoing arthroscopic bankart repair with anterior instability of glenohumeral joint with at least ≥2 episode of dislocation/subluxation, a positive clinical apprehension test and radiological evidence of glenohumeral instability and glenoid bone loss 25%, contact sports athletes, previously failed arthroscopy or open surgery, seizure disorder, multidirectional instability/habitual dislocation were exclueded. Each case was followed post operatively for atleast 1 year.Results: This series consisted of 28 patients, with the mean follow up period of 12 months, the mean pre-operative UCLA score of 18 improved to 31.75 post operatively, the mean pre-operative SST score of 4.89 improved to 10.96 post operatively. Out of 28 patients none had episodes of recurrent dislocation and anterior translation or apprehension. External rotation in 90o of abduction improved in 25 patients (89%). Conclusion: we conclude that arthroscopic bankart’s repair in recurrent shoulder dislocation with suture anchors is a reliable procedure with respect to shoulder function, recurrence rate and range of movement.
Transparent glass-ceramics based on ZnO crystals

Glass-ceramics based on hexagonal ZnO crystals can be obtained in the SiO 2 -Al 2 O 3 -ZnO-K 2 O system. The materials can be highly transparent, with ZnO crystal sizes on the order of 5-20 nm dispersed uniformly throughout an alkali aluminosilicate glass. This is one of the few transparent yet relatively highly crystalline materials based on a semiconductor crystal phase. The glass-ceramics are self-nucleating due to liquid-liquid phase separation and require no added nucleating agents. When doped with elements such as antimony or tin, these transparent glass-ceramics offer unique optical and dielectric properties, including high absorption in the near-infrared and high microwave susceptibilities.
Data Augmentation by Rubrics for Short Answer Grading

Short Answer Grading (SAG) is the task of scoring students’ answers for applications such as examinations or e-learning. Most of the existing SAG systems predict scores based only on the answers, and critical evaluation criteria such as rubrics are ignored, which plays a crucial role in evaluating answers in real-world situations. In this paper, we propose a semi-supervised method to train a neural SAG model. We extract keyphrases that are highly related to answers scores from rubrics. Weights to words of answers are calculated as attention labels instead of manually annotated attention labels, based on span-wise alignments between answers and keyphrases. Only answers with highly weighed words are used as attention supervision. We evaluate the proposed model on two analytical assessment tasks of analytic score prediction and justiﬁcation identiﬁcation . Analytic score prediction is the task of predicting the score of a given answer for a prompt, and Justiﬁcation identiﬁcation involves identifying a justiﬁcation cue in a given student answer for each analytic score. Our experimental results demonstrate that both performance of grading and justiﬁcation identiﬁcation is improved by integrating attention semi-supervised training, especially in a low-resource setting.
Quantifying Uncertainty in the Modelling Process; Future Extreme Flood Event Projections Across the UK

With evidence suggesting that climate change is resulting in changes within the hydrologic cycle, the ability to robustly model hydroclimatic response is critical. This paper assesses how extreme runoff—1:2- and 1:30-year return period (RP) events—may change at a regional level across the UK by the 2080s (2069–2098). Capturing uncertainty in the hydroclimatic modelling chain, flow projections were extracted from the EDgE (End-to-end Demonstrator for improved decision-making in the water sector in Europe) multi-model ensemble: five Coupled Model Intercomparison Project (CMIP5) General Circulation Models and four hydrological models forced under emissions scenarios Representative Concentration Pathway (RCP) 2.6 and RCP 8.5 (5 × 4 × 2 chains). Uncertainty in extreme value parameterisation was captured through consideration of two methods: generalised extreme value (GEV) and generalised logistic (GL). The method was applied across 192 catchments and aggregated to eight regions. The results suggest that, by the 2080s, many regions could experience large increases in extreme runoff, with a maximum mean change signal of +34% exhibited in East Scotland (1:2-year RP). Combined with increasing urbanisation, these estimates paint a concerning picture for the future UK flood landscape. Model chain uncertainty was found to increase by the 2080s, though extreme value (EV) parameter uncertainty becomes dominant at the 1:30-year RP (exceeding 60% in some regions), highlighting the importance of capturing both the associated EV parameter and ensemble uncertainty.
Characterization of traps at nitrided SiO2/SiC interfaces near the conduction band edge by using Hall effect measurements

The effects of nitridation on the density of traps at SiO2/SiC interfaces near the conduction band edge were qualitatively examined using a simple, newly developed characterization method that utilizes Hall effect measurements and split capacitance–voltage measurements. The results showed a significant reduction in the density of interface traps near the conduction band edge as a result of nitridation, but the interface traps were not completely eliminated by nitridation.
Automated ventilation control in mines. Challenges, state of the art, areas for improvement

The article is divided into three main parts. The first part provides an overview of the existing literature on theoretical methods for calculating the optimal air distribution in mines according to the criteria of energy efficiency and providing all sections of mines with the required amount of air. It is shown that by the current moment there are many different formulations of the problem of searching the optimal air distribution, many different approaches and methods for optimizing air distribution have been developed. The case of a single (main) fan is most fully investigated, while for many fans a number of issues still remain unresolved. The second part is devoted to the review of existing methods and examples of the automated mine ventilation control systems implementation in Russia and abroad. Two of the most well-known concepts for the development of such systems are automated ventilation control systems (AVCS) in Russia and the CIS countries and Ventilation on demand (VOD) abroad. The main strategies of ventilation management in the framework of the AVCS and VOD concepts are described and also the key differences between them are shown. One of the key differences between AVCS and VOD today is the automatic determination of the operation parameters of fan units and ventilation doors using the optimal control algorithm, which is an integral part of the AVCS. The third part of the article describes the optimal control algorithm developed by the team of the Mining Institute of the Ural Branch of the Russian Academy of Sciences with the participation of the authors of the article. In this algorithm, the search for optimal air distribution is carried out by the system in a fully automated mode in real time using algorithms programmed into the microcontrollers of fans and ventilation doors. Minimization of energy consumption is achieved due to the most efficient selection of the fan speed and the rate of ventilation doors opening and also due to the air distribution shift control and the partial air recirculation systems introduction. It is noted that currently the available literature poorly covers the issue related to emergency operation modes ventilation systems of mines and also with the adaptation of automated control systems to different mining methods. According to the authors, further development of automated ventilation control systems should be carried out, in particular, in these two areas.
Molecular dynamics simulation study on viscosity of silver nanoparticle printing ink

Ink-jet printing and ink direct writing technologies show great advantages in printing electronics and structural customization of flexible materials. The viscosity of the ink will affect the flow rate of the working medium, is an important parameter in the process of deposition. In this paper, the research status of metal particle printing ink and its rheological properties were briefly introduced. Then, water-based silver nanoparticle ink was selected as the research object, and the base liquid system was established with the TIP4P/2005 water model. The shear viscosity of the base liquid was calculated, and the accuracy of the water model in predicting the viscosity was verified. Considering the size of the silver nanoparticles, volume fraction and temperature of the three factors on the viscosity, the effects of the equilibrium molecular dynamics based on Green - Kubo formula viscosity calculation method under different conditions was calculated respectively set shear viscosity of the ink, the conclusion is temperature, volume fraction and particle size on the shear viscosity value, viscosity values associated with negative temperature, volume fraction and the viscosity value is a positive correlation, and particle size has less effect on the viscosity, particle decreases, and the viscosity value increased slightly.
Modeling 2018 Ebola virus disease outbreak with Cholesky decomposition

In this paper, we analyze a modified Susceptible‐Exposed‐Infectious‐Dead‐Recovered (SEIDR) model in the literature of the Ebola disease with uncertainties. The model is constructed using a van Kampen expansion method to have an Ebola SEIDR stochastic Fokker–Planck equation model. This model has a deterministic equation and noise covariance matrix. The basic reproduction number of the deterministic equation is calculated using the next‐generation matrix method. We prove the uniqueness and existence of the deterministic model using Lipschitz conditions and also show that it is locally asymptotically stable at it endemic equilibrium states. We constructed two equivalent stochastic differential equations (SDEs) models, whereas the Weiner process is equal to (i) the number of model equations and (ii) the number of independent changes in the model. Our aim is to solve (i) computationally using Cholesky decomposition technique with the variance–covariance matrix. Our proposed Cholesky decomposition SEIRD‐SDEs model is compared with (ii) and also with the epidemic data of the 2018 Ebola outbreak in the Democratic Republic of Congo. We also use numerical analyses to show that the importance of post‐death transmission is difficult to identify with noise terms supported by statistical hypothesis testing.
PRELIMINARY INVESTIGATIONS OF TRANSPORT IN HETEROGENEOUS RANDOM MEDIA

Random media emerge in several applications in reactor physics and safety analysis. Most often, models of stochastic media assume spatial homogeneity, whereas real-world complex materials, such as fuel chunks resulting from core degradation, typically display apparent heterogeneities. In a series of previous works, we have shown that stochastic tessellations can be successfully used in order to describe the material properties of several classes of random media. In this paper we extend these results to the case of heterogeneous random media by using Voronoi tessellations with space-dependent seed distributions, allowing for spatial gradients.
Single-Layer, Unidirectional, Broadside-Radiating Planar Quadrupole Antenna for 5G IoT Applications

In this article, an innovative quadrupole-based broadside-radiating unidirectional antenna is designed at 28.475 GHz for fifth-generation (5G) Internet of Things (IoT) applications. The planar antenna is based on a single-layer technology and realized on a flexible substrate to facilitate conformal applications. It consists of a coax-fed-driven dipole and two quadrupolar near-field resonant parasitic (NFRP) elements. The broadside-radiating design achieves a unidirectional pattern with a realized gain of 4.85 dBi and a front-to-back ratio of 9.4 dB. The total efficiency of the antenna is 85%. A differential-fed prototype was designed, fabricated, and tested at 1.579 GHz to make the measurements more manageable. The measured and simulated results are in good agreement.
Persepsi Orangtua terhadap Pelaksanaan Belajar dari Rumah pada Pendidikan Anak Usia Dini

Pandemi Covid-19 membawa dampak perubahan pada pelaksanaan pendidikan yang sedianya dilakukan secara tatap muka, disesuaikan melalui kegiatan Belajar dari Rumah (BDR). Pelaksanaan BDR yang tidak direncanakan sebelumnya oleh pendidik, peserta didik dan orang tua mendatangkan berbagai tantangan. Oleh karena itu peneliti hendak melihat persepsi orang tua terhadap pelaksanaan BDR pada anak usia 5-6 tahun pada PAUD di kota Bekasi. Kegiatan penelitian ini menggunakan metode penelitian kuantitatif dengan menggunakan kuesioner yang sudah tervalidasi selanjutnya melaksanakan penghimpunan data melalui google form. Data yang telah dihimpun diolah menggunakan program SPSS dengan analisis data chi square untuk melihat hubungan antara variabel X dan Y. Dari hasil penelitian yang dilaksanakan didapatkan hasil bahwa pelaksanaan BDR pada PAUD di kota Bekasi mendapatkan persepsi positif dari orang tua dipengaruhi oleh faktor; perencanaan pembelajaran yang disusun, media dan bahan ajar yang digunakan serta penilaian yang dilaksanakan oleh pendidik. Melalui penelitian ini memberikan gambaran bahwa pelaksanaan BDR pada PAUD dipengaruhi oleh kesiapan dan sumber daya yang dimiliki oleh lembaga PAUD, peserta didik dan orang tua murid
Modeling Particles Elements in Damaged Reinforced Concrete Structures

IN THIS PAPER, WE INTRODUCE A FINITE ELEMENT MESOSCALE MODELING OF DAMAGED CONCRETE STRUCTURES, BASED ON NODAL POSITIONS. THE MESOSCALE MODELING CONSISTS OF PARTICLE AND FIBER FINITE ELEMENTS EMBEDDED IN MATRIX FINITE ELEMENTS. WHILE THE MATRIX ELEMENTS REPRESENT THE CEMENT MATRIX, PARTICLE ELEMENTS ARE USED TO SIMULATE THE COARSE AGGREGATES AND FIBER ELEMENTS ARE USED FOR REINFORCEMENT REBARS. THE EMBEDDED THEORY IS USED TO IMMERSE THE REINFORCEMENT (BOTH PARTICLE AND FIBER ELEMENTS) WITHOUT INCREASING THE TOTAL NUMBER OF DEGREES OF FREEDOM. THIS STRATEGY DOES NOT REQUIRE NODAL COINCIDENCE, ALLOWING RANDOMLY DISTRIBUTE THE COARSE AGGREGATES. THE MATERIALS NONLINEAR BEHAVIOR IS CONSIDERED BY A SCALAR DAMAGE MODEL FOR THE CEMENT MATRIX AND COARSE AGGREGATES, AND ONE-DIMENSIONAL ELASTOPLASTIC MODEL IS USED FOR THE STEEL REBARS. FOUR EXAMPLES ARE PRESENTED, WITH GOOD CORRELATION BETWEEN NUMERICAL AND EXPERIMENTAL RESULTS. IT IS SHOWN THAT STRUCTURES SIMULATED WITH PARTICULATE ELEMENTS COULD ENDURE HIGHER LOADS FOR THE SAME DISPLACEMENT, ALTHOUGH THE MAXIMUM FORCE IS OBTAINED IN MODELS WITHOUT INCLUSION OF PARTICLE ELEMENTS.
Fast and contactless assessment of intact mango fruit quality attributes using near infrared spectroscopy (NIRS)

In recent decades, the development of fast, non-destructive and robust methods to determine agricultural products quality parameters become interesting and gaining more attentions in term of their potential applications in many field. One of those methods is near infrared spectroscopy (NIRS) which is works based on the interaction of biological matter with light radiation. The main purpose of this present study is to employ the NIRS method in assessing mango fruit quality parameters in form of soluble solids content (SSC) and vitamin C. Spectra data of absorbance NIR were acquired in wavelength range from 1000 to 2500 nm with optical gain 4x and resolution windows 0.02 nm. Prediction models were developed using partial least square regression (PLSR) followed by 10-fold cross validation. The results showed that both SSC and vitamin C of mango fruit can be determined simultaneously with maximum correlation coefficient are 0.88 and 0.87 for SSC and vitamin C respectively. Judging from its predictive abilities, it may conclude that NIRS can be used as fast and contactless method in assessing mango fruit quality parameters like SSC and vitamin C.
Situation of study (SoS) on health education implemented in a co-creation (CoC) process

ABSTRACT Situation of study (SoS) has been reported as an excellent strategy to promote students’ significant learning. This work intended to demonstrate how a SoS on health education (“Knowing cancer: a way to life”) can be implemented within the co-creation (CoC) framework. The study was carried out in a middle school, with the participation of five groups: students (14-15 years old), teachers, future teachers, university teacher trainers and health professionals. The 10 activities were carried out in school and outdoors for five months, undergoing a process of self-reflexive cycle: “reflecting and planning”, “acting and observing”, and “analyzing and reflecting”. Transcripts of debates and of students’ and teachers’ texts were subject to content analysis. This study on a topic of health education demonstrated that the Situation of Study implemented in a co-creation process was very efficient for students to develop significant learning.
Investigating the Dynamic Interlinkages between Exchange Rates and the NSE NIFTY Index

This study aims at examining the short-run and long-run dynamic linkages among exchange rates and stock market index in India through a structured cointegration and Granger causality tests. Daily exchange rates of USD, EUR, CNY, JPY, and GBP to INR along with the daily movement of NSE NIFTY for a period spanning 13 years from 6 September 2005 to 31 December 2018 were used for the analysis. The results reveal that there is no evidence for a stable long-run relationship between NSE NIFTY and the exchange rates under study. However, the VAR-based Granger causality test shows that USD, JPY, and CNY have short-run causal relationship with NSE NIFTY. The NSE NIFTY also seemed to have an influence on USD expressed in terms of Indian rupee. The impulse response analysis further supports the results of the Granger causality test and provides information on the time required for the NSE NIFTY index to recover from a shock caused by the fluctuation in exchange rates.
Translation and Validation of Personal Growth Initiative Scale-II for Pakistani Adults

Personal growth initiative is a person's active and intentional involvement in changing and developing as a person. Personal Growth Initiative Scale-II (PGIS-II; Robitschek et al., 2012) provides evidence of multidimensionality of construct of personal growth. Present research was accomplished in three phases with aim to translate and validate PGIS-II in Urdu. Phase 1 addressed the translation of measure through forward-backward translation method. To establish the cross-language validity, translated and the English version was administered on bilingual university students (N = 100). Reliability of both versions was determined by computing test-retest technique with 15 days interval. Phase-2 was aimed to establish the construct validity by carrying out. Exploratory Factor Analysis on adult women (N = 300) with age range of 21 to 52 years. Results showed four factors namely, Planfulness, Readiness for Change, Intentional Behavior, and Using Resources are reflection of personal growth initiative. Phase-3 of the research was aimed to confirm the factorial validity on sample of women (N = 300) with age range from 19 to 50 years. Findings confirmed four factor solutions and suggested that PGIS-II Urdu version can be utilized as a valid and reliable measure for the assessment of personal growth initiative among adults in Pakistan.