Miracle-dz/UniFAR-FTUs huggingface dataset:
Specifying the Relations among PTSD Symptom Clusters and Parenting Stress in Mothers Engaged in Substance Use Treatment

Abstract Introduction Parenting stress is often heightened in mothers receiving treatment for substance use. Experiences of trauma are commonly seen in this population, which may give rise to Posttraumatic Stress Disorder (PTSD) symptoms, including intrusion, avoidance, negative cognition and mood, and affective arousal. While past research has demonstrated a significant relation between PTSD symptoms and parenting stress, no studies have examined the relative contributions of these symptoms to parenting stress in mothers engaged in substance use treatment. Methods Seventy-four mothers attending outpatient substance use treatment who were parenting children aged 0–3 years completed measures of parenting stress, PTSD, substance use, and depression symptoms. Results A canonical correlation analysis indicated two canonical variates accounting for significant variance between PTSD symptom clusters and parenting stress measures. The first canonical variate, primarily reflecting depressive and PTSD cognition and mood symptoms, was predominantly related to the parental distress aspect of parenting stress (40%). The second canonical variate, primarily reflecting intrusion and avoidance PTSD symptoms, was associated with increased parental perceptions of their child as difficult (10%). Conclusion Future research directions and clinical implications of these results are discussed for designing parenting interventions with mothers attending substance use treatment who present with PTSD symptoms.
Potential and challenges for an integrated management of tuberculosis, diabetes mellitus, and hypertension: A scoping review protocol

In many low- and middle-income countries (LMICs), the epidemiological transition is characterized by an increased burden of non-communicable diseases (NCDs) and the persistent challenge of infectious diseases. The transmission of tuberculosis, one of the leading infectious diseases, can be halted through active screening of risk groups and early case findings. Studies have reported comorbidities between tuberculosis (TB) and NCDs, which necessitates the development of an integrated disease management model. This scoping review discusses the possibilities and problems of integration in managing TB and NCDs, with a particular emphasis on diabetic mellitus (DM) and hypertension screening and control. We will conduct this review following Arksey and O’Malley’s framework for scoping review. We will use key terms related to integrated management, i.e., screening, diagnosis, treatment, and care, of TB, DM, and hypertension in PubMed, Scopus Database, and ScienceDirect for research published from January 2005 to July 2021. This review will also consider grey literature, including unpublished literature and international disease management guidelines on TB, DM, and hypertension from WHO or other health professional organization. We will export the search results to citation manager software (EndNote). We will remove duplicates and apply the inclusion and exclusion criteria to identify the set of papers for the review. After screening the titles and abstract, two authors will independently review the full text of selected studies and extract the data. We will synthesize all selected studies qualitatively and the results will be discussed with the experts. The results will be used as the basis of the development of a guideline for integrated TB, DM, and hypertension management.
Do Agency and Communion Explain the Relationship Between Perceiver and Target Effects in Interpersonal Perception? A Meta-Analysis on Generalized Reciprocity

This meta-analysis examines generalized reciprocity, that is, the relationship between how people perceive others and how they are perceived by others. It tests the hypothesis that generalized reciprocity varies as a function of the content domain under investigation. Generalized reciprocity for attributes with primarily communal content (e.g., friendliness) was hypothesized to be more positive than generalized reciprocity for attributes with primarily agentic content (e.g., assertiveness). Sixty-four primary studies reporting correlations between perceiver and target effects with a total number of 17,561 participants were included in the analysis. Results of a multilevel meta-analytical random effects model showed that reciprocity correlations were slightly negative, but around zero, for primarily agentic attributes (r = −.05) and became more positive with increasing communal content (up to r = .18 for primarily communal attributes). Generalized reciprocity thus varied depending on the extent to which the regarded attribute is agentic versus communal.
Intelligibility of pseudo-whispered speech after total laryngectomy

ABSTRACT This study aimed to assess the intelligibility of so-called ‘pseudo-whispered speech’ (pseudo-WS), as produced without voice nor pulmonic airstream by some alaryngeal patients prior to rehabilitation. Several perception tests were submitted to three experienced clinicians and three naive listeners, relying on the speech samples of 20 French native speakers: 10 alaryngeal speakers, solely using pseudo-WS when starting speech therapy up to six months after total laryngectomy, and 10 control speakers, recorded in the closest speech mode available, whispered speech (WS). Experts were asked to identify consonants (C) in the /a/+C+/a/ context and to rate intelligibility, unintended additive noise, and fluency on a likert-scale, while naive listeners completed a quantitative test of intelligibility. Intelligibility of WS was found to be high, with scores ranging from 46.33/54 to 53.67/54 (median 52.5, interquartile range 2.33) for the quantitative test, and segmental intelligibility ranging from 68.75% to 94.79% (median 87.5, interquartile range 17.71). Segmental confusion affected voicing in favour of unvoiced consonants, as previously reported in the literature. By contrast, intelligibility of pseudo-WS was found to be poor, with scores ranging from 1/54 (unintelligibility) to 28.33/54 (median 8.66, interquartile range 14.67) for the quantitative test, and segmental intelligibility ranging from 3.13% to 28.13% (median 9.24, interquartile range 14.58). Segmental intelligibility was not uniformly affected: stops, labials and unvoiced consonants were better identified than other categories. Finally, a significant correlation was found between global intelligibility and articulatory precision, while unintended additive noise and fluency seemed to play no role.
Dying from ALS in Sweden: clinical status, setting, and symptoms

Abstract Objectives This retrospective cohort study aims to provide a comprehensive account of death in Swedish patients with ALS, including clinical status preceding death, the death setting, as well as symptoms. Methods The study presents detailed information on a cohort of patients with ALS from Stockholm, Sweden, deceased in 2018–2020. In addition, selected information is presented on a larger complementary cohort of ALS patients from all regions of Sweden deceased in 2011–2020. Data were obtained from patient medical records, the Swedish Motor Neuron Disease Quality Registry, and the Swedish Quality Registry of Palliative Care. Results Ninety-three patients were included in the main cohort and 2224 patients in the complementary cohort. In the main cohort, there was a slow decline in weight and motor function during the 12 months preceding death. Most (93.4%) anticipated/prolonged deaths occurred in a palliative care unit, at home, or in an assisted living facility while 44.8% of precipitous deaths occurred in a hospital ward. Next of kin or health care staff were present at death for most patients (78.7%). In the final week of life, 41.1% experienced at least one symptom (either pain, anxiety, confusion, or dyspnea) that was only partially relieved or not at all. Conclusion The majority of patients died in their own homes or at a palliative unit in the presence of next of kin and most symptoms were adequately managed. This paper might be used in educating patients, next of kin as well as health professionals, decreasing uncertainty surrounding the end of life.
Discriminative Coefficient Collaborative Representation for Image Recognition

As classical technique, dictionary learning has been widely used for image classification. But the time consumption and the powerful for image classification are still problems in dictionary learning process. In this paper we optimized an advanced dictionary learning method with employing collaborative method into the process. Then, the discriminative information of the representation coefficients is obtained. We embedded the discriminative information to the CRC algorithm to do image recognition. The proposed method has been proven its superiority by some exhaustive experiments at AR and Caltech 101 databases.
‘I bring her up with love:’ Perspectives of caregivers of children with neurodevelopmental delays in western Kenya

Abstract Objective This study aims to understand the challenges and perspectives of caregivers with neurodevelopmental delays (NDD) in rural Kenya. Methods Semi‐structured interviews and the Affiliate Stigma Scale were administered to the primary caregivers of children with NDDs recruited from the communities near Eldoret, Kenya. Constant comparison and triangulation methods were used to inductively develop relevant themes and concepts. Results Sixteen caregivers participated. Challenges, which included hardships related to safety and supervision, challenging emotions and financial difficulties, were compounded by a lack of social support and community stigma towards these children. However, caregivers still felt deep love for their children, desired acceptance from the community and found sources of strength from faith and religious institutions. Conclusion The study uncovered crucial insights into the perspectives of caregivers within this population and revealed a paucity of disability awareness and understanding within the community, possibly informing future programmes and intervention policies.
International controlled study of revascularization and outcomes following COVID‐positive mechanical thrombectomy

Previous studies suggest that mechanisms and outcomes in patients with COVID‐19‐associated stroke differ from those in patients with non‐COVID‐19‐associated strokes, but there is limited comparative evidence focusing on these populations. The aim of this study, therefore, was to determine if a significant association exists between COVID‐19 status with revascularization and functional outcomes following thrombectomy for large vessel occlusion (LVO), after adjustment for potential confounding factors.
Cost effectiveness of the first stage recovery of a small satellite launcher

An increase in the amount of launched satellites can be seen in the last decade. And it is expected that even more satellites will be launched in the upcoming years. Most of these small satellites are launched as piggy back together with a large spacecraft. The location and time of launch and orbit will therefore be determined by another mission. A dedicated launcher for small satellites will contribute to the success of small satellites by bringing the satellite at the right time in the right orbit. Fourteen European companies and institutes are working together in a European Union (EU) Horizon 2020 project called “SMall Innovative Launcher for Europe” (SMILE). The project aims at designing a launcher for satellites up to 70 kg and a European-based launch facility at Andoya. To make this project a success the launch cost must be below the " 50 000 per kg and a total launch cost of 3.5 "M. One of the ways to cut the costs of the launcher is by the re-use of the first stage. This research will answer the question if recovering of the first stage will be cost-beneficial, answering the following research question; What is the performance gain in terms of cost when reusing the first stage of the launcher within the SMILE project? To answer this question, three different steps are taken. The first step is to investigate the boundaries of the recovery of the first stage. The impact region, velocity and maximum altitude and loads are investigated to understand the recovery mechanisms needed. It is found that the impact region of the first stage is between the coast of Norway and Jan Mayen. This means that the first stage needs to land on water. Using the information found, seven different recovery options are designed. During the second phase the different designs are optimised to the minimumtake-off weight. This optimisation is done by first making use of Monte Carlo simulations to find the region were the minimal is found. The results of the Monte Carlo simulation are used in a genetic algorithm the find the minimum system weight. After this evaluation two different options remained; retro-propulsion option and a parachute system option. The last step is to evaluate these two options in more detail with a six degrees of freedom simulation. After the evaluation of the two options, the options are designed in more detail. Three different landing techniques are discussed; resulting in three different options. The first option found is the retro-propulsion with an airbag landing. The second option considered is the parachute system with an air bed landing. The last option found is the parachute system with a mid air capture performed by a helicopter. The different options are re-designed and the extra weight and volume needed is computed. The cost of the different options is calculated and compared. It is shown that if the first stage is used four times of more per year, recovering is cost-beneficial for all options.
Role of Sarcopenia in Advanced Malignant Cutaneous Melanoma Treated with Immunotherapy: A Meta-Analysis

Introduction: The role of sarcopenia in malignant cutaneous melanoma is unclear. The aim of the present meta-analysis was to analyze the prevalence and clinical role of sarcopenia in patients with advanced cutaneous melanoma based on a large cohort. Methods: MEDLINE, Cochrane, and SCOPUS databases were checked for relationships between sarcopenia and clinical outcomes in melanoma up to September 2021. Overall, 6 studies including 719 patients met the inclusion criteria. The meta-analysis was performed using RevMan 5.3 software. Results: The prevalence of sarcopenia was 40.23%. Sarcopenia did not influence dose-limiting toxicity of treatment, hazard ratio (HR) 1.01, 95% CI (0.70–1.47). Sarcopenia was associated with lower progression-free survival (PFS): HR 1.49, 95% CI (0.98–2.26), and lower overall survival (OS): HR 1.67, 95% CI (1.11–2.52). Conclusions: The cumulative prevalence of sarcopenia in malignant cutaneous melanoma is 40.77%. Sarcopenia is slightly associated with PFS and OS and it is not associated with treatment toxicity.
Structure‐guided engineering of key amino acids in UGT85B1 controlling substrate and stereo‐specificity in aromatic cyanogenic glucoside biosynthesis

SUMMARY Cyanogenic glucosides are important defense molecules in plants with useful biological activities in animals. Their last biosynthetic step consists of a glycosylation reaction that confers stability and increases structural diversity and is catalyzed by the UDP‐dependent glycosyltransferases (UGTs) of glycosyltransferase family 1. These versatile enzymes have large and varied substrate scopes, and the structure–function relationships controlling scope and specificity remain poorly understood. Here, we report substrate‐bound crystal structures and rational engineering of substrate and stereo‐specificities of UGT85B1 from Sorghum bicolor involved in biosynthesis of the cyanogenic glucoside dhurrin. Substrate specificity was shifted from the natural substrate (S)‐p‐hydroxymandelonitrile to (S)‐mandelonitrile by combining a mutation to abolish hydrogen bonding to the p‐hydroxyl group with a mutation to provide steric hindrance at the p‐hydroxyl group binding site (V132A/Q225W). Further, stereo‐specificity was shifted from (S) to (R) by substituting four rationally chosen residues within 6 Å of the nitrile group (M312T/A313T/H408F/G409A). These activities were compared to two other UGTs involved in the biosynthesis of aromatic cyanogenic glucosides in Prunus dulcis (almond) and Eucalyptus cladocalyx. Together, these studies enabled us to pinpoint factors that drive substrate and stereo‐specificities in the cyanogenic glucoside biosynthetic UGTs. The structure‐guided engineering of the functional properties of UGT85B1 enhances our understanding of the evolution of UGTs involved in the biosynthesis of cyanogenic glucosides and will enable future engineering efforts towards new biotechnological applications.
E cacy and Acceptability of Parent-only Group Cognitive Behavioral Intervention for Treatment of Anxiety disorder in Children and Adolescents: A Meta-analysis of Randomized Controlled Trials

Bangmin Yin Chongqing Medical University First A liated Hospital Teng Teng Chongqing Medical University First A liated Hospital Lyu Tong China Medical University Xuemei Li Chongqing Medical University First A liated Hospital Li Fan Chongqing Medical University First A liated Hospital Xinyu Zhou Chongqing Medical University First A liated Hospital Peng Xie (  xiepeng973@126.com ) The First A ated Hospital of Chongqing Medical University https://orcid.org/0000-0002-8104-9230
Molecular and serological detection of Toxoplasma gondii infection in mammals in the Taipei Zoo

Toxoplasmosis caused by Toxoplasma gondii affects both conservation and public health efforts. In the Taipei Zoo, toxoplasmosis was diagnosed in ring‐tailed lemurs and a meerkat in 2019 while a freeze–thaw meat strategy had been applied to carnivores before the event. To investigate the possible risk factors associated with T. gondii infection in the Taipei Zoo, 179 veterinary visiting mammals from 2019–2021 and six stray cats were included to detect anti‐T. gondii IgG and IgM in their serum via ELISA, and T. gondii in their faeces and blood via PCR. Although the overall T. gondii IgG seroprevalence was 33.5% and PCR positivity was 16.2% in the zoo mammals, the correlation between T. gondii PCR and systemic IgG results was low. An omnivorous diet (adjusted OR = 0.4; 95% CI: 0.2–1.0), a herbivorous diet (adjusted OR = 3.2; 95% CI: 1.1–9.6), and animals in the Conservation Area where stray cats appeared (adjusted OR = 18.3; 95% CI: 3.9–85.9) were independent risk factors for T. gondii infection. The low T. gondii‐specific IgM positivity (0.6%) suggests that most animals did not have acute T. gondii infection. In conclusion, our findings indirectly support that feeding frozen meat to carnivores, cleaning fresh food, and restricting access to stray cats to prevent faecal contaminants could prevent animals from T. gondii exposure.
The Effects of Skin Temperature Changes on the Integrity of Skin Tissue: A Systematic Review

ABSTRACT OBJECTIVE To determine whether changes in skin temperature can affect the integrity of skin. METHODOLOGY The authors conducted a systematic literature search as per the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines. They searched the CINAHL (Cumulative Index to Nursing and Allied Health Literature), Cochrane, MEDLINE Complete, Academic Search Ultimate, and HyDi databases for articles examining the effects of skin temperature on skin integrity published through April 2020. Two independent reviewers scored the methodologic quality of the 13 included studies. RESULTS Only 11 studies were included in the qualitative analysis, as the other two articles had a critical risk of bias. There is strong evidence to indicate that an increase in skin temperature leads to changes in skin structure and function. However, ulcer formation was more affected by intrinsic and extrinsic factors, rather than by temperature alone. CONCLUSION Further high-quality randomized controlled trials are required to investigate the direct effect of skin temperature on ulceration.
LINC00963 May Be Associated with a Poor Prognosis in Patients with Cervical Cancer

Background Recently, the upregulation of LINC00963 expression has been reported in various cancer subtypes. LINC00963 expression can promote cancer cell invasion and metastasis. However, the clinical significance of LINC00963 in cervical and endocervical cancer (CESC) has remained relatively unexamined. Material/Methods We assessed the mRNA expression of LINC00963 in patients with CESC based on data acquired from The Cancer Genome Atlas (TCGA) to determine pathways involved in CESC pathogenesis with respect to LINC00963. We included 3 normal and 304 tumor samples in this study. Results The scatter plot and paired plot showed differences in LINC00963 expression between normal and tumor samples (P<0.01). Overall survival (OS) analysis revealed that CESC patients with high expression of LINC00963 demonstrated worse prognosis than CESC patients with low expression of LINC00963 (P<0.01). Multivariate analysis with the Cox proportional hazards model indicated that the expression of LINC00963 (HR 0.297; 95% CI 0.115–0.776; P=0.012) and primary therapy outcome (HR 0.162; 95% CI 0.059–0.446; P=0.001) were independent prognostic factors for patients with CESC. GSEA results showed that reactome biological oxidations, inflammasomes, apoptosis, toll-like receptor signaling pathway, JAK/STAT signaling pathway, and NF-κB activation were differentially enriched in CESC samples with the high LINC00963 expression phenotype. Conclusions Our results confirmed the association of significantly high levels of LINC00963 expression in CESC with several observed clinical features. LINC00963 may be a potentially useful prognostic molecular biomarker associated with poor survival in patients with CESC.
Adaptive Iterative Learning Fault-Tolerant Consensus Control of Multiagent Systems Under Binary-Valued Communications

In this article, the iterative learning averaging consensus problem is studied for multiagent systems with system uncertainties, actuator faults, and binary-valued communications. Considering only binary-valued measurement information with stochastic noise can be received from its neighbors for each agent, a new two-iteration-scale framework that alternates estimation and control is designed. Under the proposed framework, each agent estimates the neighbors’ states based on the empirical measurement method during a dwell iteration interval, during which each agent’s states will keep constant along the iteration axis. Further, in view of the impacts of system uncertainties and actuator faults, a novel adaptive iterative learning fault-tolerant averaging consensus control scheme is designed based on its own states and the estimated neighbors’ states. Finally, the resulting closed-loop system is rigorously proved to be stable, and numerical simulations are conducted to demonstrate the effectiveness of the developed control strategy.