Miracle-dz/UniFAR-FTUs huggingface dataset:
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to isolated soy protein and reduction of blood LDL-cholesterol concentrations pursuant to Article 14 of Regulation (EC) No 1924/2006

differences in the results obtained between trials appear unrelated to the dose of ISP used, to sample size or to study duration, and that the evidence provided in support of a possible mechanism was not convincing. A cause and effect relationship has not been established between the consumption of ISP (as defined by the applicant) and a reduction in blood LDL-cholesterol concentrations. region of the soybean α’ subunit on LDL-receptor mediated LDL uptake and degradation in a human hepatoma cell line (Hep G2). The also presented one animal study in male Sprague-Dawley rats, which assessed the effect of soybean 7S globulin and soybean 7S globulin α’ subunit on blood cholesterol concentrations and β-VLDL receptor activity. The that results from rat studies cannot be extrapolated to humans because of differences in lipid metabolism between these two species, that the evidence provided did not establish that peptides derived from the intestinal digestion of ISP can be absorbed intact and that the evidence provided in the in vitro studies is not sufficient to predict an effect of peptides derived from the soybean 7S globulin α’ subunit on the LDL-receptor mediated LDL uptake and degradation in humans.
Coupled soliton solutions of modeled equations in a Noguchi electrical line with crosslink capacitor

An electrical line is one of the transmission media used worldwide for the transmission of signals. This is for the fact that it is less expensive and easy to manufacture than the other transmission media. In linear domain, the electrical lines transmit sinusoidal signals whose amplitude decreases exponentially and loss a lot of energy. It is therefore necessary to valorize electrical lines by enabling them to transmit solitary waves which are more stable and do not dissipate energy. This will be possible if the media of transmission line are dispersive and nonlinear. We define the analytical expressions that the charges of capacitors must obey so that the Noguchi electrical line with crosslink capacitor accepts to propagate a coupled solitary wave of the need type. The application of those definitions and Kirchhoff laws to the networks of a modified Noguchi electrical line with crosslink capacitor have enable to obtain new set of higher-order nonlinear partial differential equations which govern the dynamics of a coupled solitary wave in the said line. The construction of coupled solitary waves solutions of those set of equations by direct and effective mathematical methods notably that of Bogning-Djeumen Tchaho-Kofane [16–22] has permitted to discover that, solitary waves of type (Kink; Kink) and type (Pulse; Pulse) are easily propagated in that line when certain conditions we have elaborated are respected. The Noguchi electrical line with crosslink capacitor that we have studied is advantageous for the fact that it permits simultaneously the propagation of a set of two solitary waves contrary to a non-coupled Noguchi electrical line which only enables the propagation of one solitary wave when the signal considered is the voltage; the more we will multiply the crosslink in the line, the more we will multiply the simultaneous propagation of solitary wave in the line.
Shape model-based point set registration with local density weighting applied to the incomplete femur

Pre-operative planning aids clinicians by providing insight into patient-speciﬁc problems before surgery is performed. For treatment of femoroacetabular impingement (FAI), a range of motion (ROM) simulation is used, based on collision detection on segmented CT or MRI-data. Imaging data of the femur is often incomplete, due to the fact that radiol-ogists want to minimize radiation dose and scanning time. The lack of data negatively inﬂuences the range of motion simulation. In this research we present a statistical shape model (SSM) based point set registration method that is able to accurately register to incomplete femur data. It is based on an iterative schema that minimizes the squared distance between the target data and the modes of variation in the SSM. We introduce a weighting vector that is derived from point density in the target data to force each point to equally contribute to the ﬁnal solution. This greatly improved registration performance in the distal femur region. Furthermore, we introduced an iteratively increasing amount of modes of variation in the solving approach. This lead to faster convergence while achieving more accurate registration. The implemented method outperforms current state-of-the-art registration algorithms.
Three Polymorphisms of Vascular Endothelial Growth Factor (+936C 9 T, j 460C 9 T, and j 2578C 9 A) and Their Susceptibility to Ovarian Cancer A Meta-Analysis

Objective: Vascular endothelialgrowth factor (VEGF) is a potent endothelial cell mitogenthat plays a vital role in angiogenesis, tumor growth, and metastasis. The associations between 3polymorphismsofVEGF(+936C 9 T, j 2578C 9 A,and j 460C 9 T)andovariancancer(OC) risk have been extensively investigated, but the currently available results are inconsistent. To obtainamoreaccurateestimationoftheassociation,ameta-analysiswasconductedinthisstudy. Methods: PubMed, Cochrane Library, Embase, and Chinese National Knowledge Infra-structure were searched for all relevant studies published before November 30, 2014. Odds ratios(ORs) and 95% confidenceintervals (CIs)were calculatedfor the VEGFpolymorphisms to assess the strength of the association. Results: With regard to the +936C 9 T polymorphism, 5 articles were available for analysis (882 cases and 1155 controls), whereas for j 2578C 9 A (559 cases and 632 controls) and j 460C 9 T (350 cases and 409 controls), only 2 articles were eligible for analysis, re-spectively. A significant association between the VEGF +936C/T polymorphism and OC was demonstrated in white populations (CT vs CC: OR, 0.638 [95% CI, 0.437 Y 0.932; P = 0.020]; TT + CT vs CC: OR, 0.694 [95% CI, 0.483-0.995; P = 0.047]). No relationship was found between j 2578C 9 A and j 460C 9 T and susceptibility to develop OC. Conclusions: This meta-analysis provides supportive evidence that the VEGF +936C/T polymorphism may influence the risk for the development of OC in a protective model among whites.
Cloud Storage Confidentiality and Secrecy using Encryption, Obfuscation Techniques: A survey

- Cloud computing provides an vast amount of virtual storage to the users for storing its valuable data. Which helps to small and medium scale industry to use with pay as you go basis. Users’ information are stored in the premises of Cloud service provider in public environment. Data stored in the cloud storage is available to all the users from anywhere. This will lead to the data safety issue in cloud storage for both Users and for providers. If the privacy of cloud user’s data is broken, then it will affect on reputation of Providers. Cloud data security can be discussed using various parameters like Data on rest i
Competitive Targeted Marketing and Technology Diffusion (cid:13)

In this paper, we consider two innovating firms diffusing incompatible technologies and their decision of consumer targeting. The technology adoption is made in two steps. First, once the firms sell their products to their respective targeted consumer, the technology is diffused successively by word-of-mouth communication from the initial consumer to other consumers linked along the network. Then, in the second step, each consumer imitates the technology the neighbors use which fares better, and through this process of imitation, the technology distribution keeps evolving until it reaches the long-run steady state. We consider two cases; when firms are myopic enough to neglect the imitation possibility and when they are sophisticated enough to take the possibility into account. We demonstrate that if firms are myopic, the early innovator chooses the minmax location which surprisingly turns out to be equivalent to the node with the highest closeness centrality. On the other hand, if firms are sophisticated, the best target will tend towards a hub, although the minmax principle in general keeps valid in the sense that it should be the minmax location after considering imitation.
A model of information diﬀusion in interconnected online social networks

Online social networks (OSN) have today reached a remarkable capillary diﬀusion. There are numerous examples of very large platforms people use to communicate and maintain relationships. People also subscribe to several OSNs, e.g, people create accounts on Facebook, Twitter, and so on. This phenomenon leads to online social internetworking (OSI) scenarios where users who subscribe to multiple OSNs are termed as bridges . Unfortunately, several important features make the study of information propagation in an OSI scenario a diﬃcult task, e.g., correlations in both the structural characteristics of OSNs and the bridge inter-connections among them, heterogeneity and size of OSNs, activity factors, cross-posting propensity, etc. In this paper we propose a directed random graph-based model that is amenable to eﬃcient numerical solution to analyze the phenomenon of information propagation in an OSI scenario; in the model development we take into account heterogeneity and correlations introduced by both topological (correlations among nodes degrees and among bridge distributions) and user-related factors (activity index, cross-posting propensity). We ﬁrst validate the model predictions against simulations on snapshots of interconnected OSNs in a reference scenario. Subsequently, we exploit the model to show the impact on the information propagation of several characteristics of the reference scenario, i.e., size and complexity of the OSI scenario, degree distribution and overall number of bridges, growth and decline of OSNs in time, and time-varying cross-posting users propensity.
Correlation between tug-back and cone fitness in curved root canals prepared with reciprocating files

The purpose of this study was to compare the gutta-percha-occupied area (GPOA) of two gutta-percha cones with different size and taper using micro-computed tomographic (micro-CT) imaging and to evaluate the relationship between GPOA and tug-back in curved root canals instrumented with reciprocating files. Under the conditions of this study, tug-back can be a definitive determinant for indicating higher cone fitness in the curved root canal prepared with reciprocating files regardless of the cone type.
Interactive comment on “Tropical temperature variability and Kelvin wave activity in the UTLS from GPS RO measurements” by Barbara

Scherllin-Pirscher et al. use GPS radio occultation data to examine temperature variability in the tropical UTLS. Using spectral analysis, the authors identify contributions of temperature variability from quasi-stationary and sub-seasonal (<100 days) scales to the total variance. This study particularly focuses on Kelvin waves and their relation-ship with the QBO and convective forcing. The paper is nicely organized and easy to follow. It is interesting that their analysis on Kelvin wave activity in the tropopause does not show a QBO signal. I wonder if the result is affected by the calculation method to get Kelvin wave variance. Therefore, I recommend that the authors check the following points before publication in ACP.
Smart Vehicular Communication: A Survey

- Vehicular communication has received widespread recognition from Industry and Research due to their strong potential to provide effective commutation facility by improving safety on roads and traffic efficiency. In this paper, an all-inclusive survey of recent works related to smart Vehicular communication and implementation of various Machine learning techniques for road type prediction and levels of traffic congestion are examined. Some important features such as estimation of Vehicular channel modeling alongside with resource allocation, intelligent wireless resource management are studied and various methodologies such as Finite-State Markov Chain (FSMC), Deep-Q-Network (DQN) algorithm are analyzed. Several performance parameters are examined for Device-to-Device (D2D) based network such as Instance resource allocation schemes, design criterion for network selection. We aim to discover the challenges faced by the modern vehicular communication system.
12 th European Congress on Energy Efficiency and Sustainability in Architecture and Urbanism (EESAP 12) and 5 th International Congress on Advanced Construction (CICA 5)

: This paper presents a novel framework for the analysis of heat consumption data of buildings connected to a district-heating network using machine learning techniques. The high variability and uncertainty of energy production in new district-heating networks make highly important to have deep insightful knowledge of the instant demand of all the buildings connected to the grid. Thus, the present paper presents a methodology for discovering heat consumption patterns in the buildings as well as a black-box model for heat load prediction. The approach to analyzing the consumption data is carried out by a combination of unsupervised and supervised learning models. The unsupervised learning of the heat consumption patterns is carried out using the widely used k-means algorithm, whereas supervised random-forest algorithm is applied for heat-load forecasting. The proposed framework is applied to a real residential building located in Tartu (Estonia) and connected to a subnetwork of the district-heating network of this location. The unsupervised clustering results in three main day-types with different consumption patterns throughout these days. Silhouette index is used for the validation of the clusters. The outcome from the heat load prediction model results in prediction accuracy over 0.95 for the R 2 value.
InflammationCigarette Smoke-Mediated Lung Shp2 Plays an Important Role in Acute

Cigarette smoke (CS), the major cause of chronic obstructive pulmonary disease, contains a variety of oxidative components that were implicated in the regulation of Src homology domain 2-containing protein tyrosine phosphatase 2 (Shp2) activity. However, the contribution of Shp2 enzyme to chronic obstructive pulmonary disease pathogenesis remains unclear. We investigated the role of Shp2 enzyme in blockading CS-induced pulmonary inﬂammation. Shp2 levels were assessed in vivo and in vitro. Mice (C57BL/ 6) or pulmonary epithelial cells (NCI-H292) were exposed to CS or cigarette smoke extract (CSE) to induce acute injury and inﬂammation. Lungs of smoking mice showed increased levels of Shp2, compared with those of controls. Treatment of lung epithelial cells with CSE showed elevated levels of Shp2 associated with the increased release of IL-8. Selective inhibition or knockdown of Shp2 resulted in decreased IL-8 release in response to CSE treatment in pulmonary epithelial cells. In comparison with CS-exposed wild-type mice, selective inhibition or conditional knockout of Shp2 in lung epithelia reduced IL-8 release and pulmonary inﬂammation in CS-exposed mice. In vitro biochemical data correlate CSE-mediated IL-8 release with Shp2-regulated epidermal growth factor receptor/Grb-2–associated binders/MAPK signaling. Our data suggest an important role for Shp2 in the pathological alteration associated with CS-mediated inﬂammation. Shp2 may be a potential target for therapeutic intervention
“It’s not just about decline…” Exploration of Party Membership Lifecycles in a Multi-level System. The case of Belgium, 1990-2004

The impact of infra-national dynamics on party membership has been understudied so far. This is rather surprising as recent studies have shown the importance of local and regional context for political participation and party competition (Remmer, 2009; Müller, 2013; Oliver, 2014). This paper suggests to explore this issue by testing the differentiated effect of electoral district size, national and regional election cycles on party membership fluctuations in the Belgian multilevel system. Based on a subset of MAPP data on Belgian party members disaggregated at the electoral district level over a period from 1990 to 2004, this paper shows that fluctuations of party membership ratios are linked to party level factors and to regional context. It also shows a differentiated impact of national and regional elections as mobilization factors.
Characterization of b-Aminolevulinic Acid Formation in Soybean Root Nodules1

Formation of the heme precursor &-aminolevulinic acid (ALA) was studied in soybean root nodules elicited by Bradyrhizobium japonicum. Glutamate-dependent ALA formation activity by soy- bean (Glycine max) in nodules was maximal at pH 6.5 to 7.0 and at 55 to 600C. A low level of the plant activity was detected in uninfected roots and was 50-fold greater in nodules from 17-day-old plants; this apparent stimulation correlated with increases in both plant and bacterial hemes in nodules compared with the respective asymbiotic cells. The glutamate-dependent ALA for- mation activity was greatest in nodules from 17-day-old plants and decreased by about one-half in those from 38-day-old plants. Unlike the eukaryotic ALA formation activity, B. japonicum ALA synthase activity was not significantly different in nodules than in cultured cells, and the symbiotic activity was independent of nodule age. The lack of symbiotic induction of B. japonkum ALA synthase indicates either that ALA formation is not rate-limiting, or that ALA synthase is not the only source of ALA for bacterial heme synthesis in nodules. Plant cytosol from nodules catalyzed the formation of radiolabeled ALA from U-['4C]glutamate and 3,4- [3H]glutamate but not from 1-[14C]glutamate, and thus, operation of the C5 pathway could not be confirmed.
BasophilsTransendothelial Migration of Human

During allergic reactions, basophils migrate from the blood compartment to inﬂammatory sites, where they act as effector cells in concert with eosinophils. Because transendothelial migration (TEM) represents an essential step for extravasation of cells, for the ﬁrst time we have studied basophil TEM using HUVEC. Treatment of HUVEC with IL-1 (cid:1) signiﬁcantly enhanced basophil TEM, which was further potentiated by the presence of a CCR3-speciﬁc ligand, eotaxin/CCL11. In addition to CCR3 ligands, MCP-1/ CCL2 was also active on basophil TEM. Although stromal cell-derived factor-1/CXCL12, a CXCR4 ligand, failed to induce TEM in freshly isolated basophils, it caused strong TEM in 24-h cultured cells. IL-3 enhanced basophil TEM by increasing the chemokinetic response. Spontaneous TEM across activated HUVEC was inhibited by treatment of cells with anti-CD18 mAb, but not with anti-CD29 mAb, and also by treatment of HUVEC with anti-ICAM-1 mAb. Anti-VCAM-1 mAb alone failed to inhibit TEM, but showed an additive inhibitory effect in combination with anti-ICAM-1 mAb. In contrast, eotaxin- and IL-3-mediated TEM was signiﬁcantly inhibited by anti-CD29 mAb as well as anti-CD18 mAb. These results indicate that (cid:1) 2 integrins play the primary role in basophil TEM, but (cid:1) 1 integrins are also involved, especially in TEM of cytokine/chemokine-stimulated basophils. In conclusion, the regulatory proﬁle of basophil TEM is very similar to that reported for eosinophils. Our results thus support the previous
Analysis of the Roles of 14-3-3 in the Platelet Glycoprotein Ib-IX–mediated Activation of Integrin (cid:97) IIb (cid:98) 3 Using a Reconstituted Mammalian Cell Expression Model

We have reconstituted the platelet glycoprotein (GP) Ib-IX–mediated activation of the integrin (cid:97) IIb (cid:98) 3 in a recombinant DNA expression model, and show that 14-3-3 is important in GPIb-IX signaling. CHO cells expressing (cid:97) IIb (cid:98) 3 adhere poorly to vWF. Cells expressing GPIb-IX adhere to vWF in the presence of botrocetin but spread poorly. Cells coexpressing integrin (cid:97) IIb (cid:98) 3 and GPIb-IX adhere and spread on vWF, which is inhibited by RGDS peptides and antibodies against (cid:97) IIb (cid:98) 3 . vWF binding to GPIb-IX also activates soluble ﬁbrinogen binding to (cid:97) IIb (cid:98) 3 indicating that GPIb-IX mediates a cellular signal leading to (cid:97) IIb (cid:98) 3 activation. Deletion of the 14-3-3–binding site in GPIb (cid:97) inhibited GPIb-IX–mediated ﬁbrinogen binding to (cid:97) IIb (cid:98) 3 and cell spreading on vWF. Thus, 14-3-3 fibrinogen in the presence of 1 mg/ml ristocectin but in the absence of vWF. RGDS peptide (1 mM) was added in parallel assays for estimation of specific fibrinogen binding to the integrin. We showed previously that 1 mM RGDS completely abolished fibrinogen binding to integrin (cid:97) IIb (cid:98) 3 while 1 mM RGES had no effect (Du et al., 1991). Fibrinogen binding was ana- lyzed by flow cytometry.
May 09, 2020 Recombination-stable multimeric green fluorescent protein for characterization of weak promoter outputs

23 Green fluorescent proteins (GFPs) are widely used for visualization of proteins to 24 track localization and expression dynamics. However, phenotypically important 25 processes can operate at too low expression levels for routine detection, i.e. be 26 overshadowed by autofluorescence noise. While GFP functions well in translational 27 fusions, the use of tandem GFPs to amplify fluorescence signals is currently avoided 28 in Saccharomyces cerevisiae and many other microorganisms due to the risk of loop- 29 out by direct-repeat recombination. We increased GFP fluorescence by translationally 30 fusing three different GFP variants, yeast-enhanced GFP, GFP+ and superfolder GFP 31 to yield a sequence-diverged triple GFP molecule 3vGFP with 74-84 % internal repeat 32 identity. Unlike a single GFP, the brightness of 3vGFP allowed characterization of a 33 weak promoter in S. cerevisiae . Utilizing 3vGFP, we further engineered a less leaky 34 Cu 2+ -inducible promoter based on CUP1. The basal expression level of the new 35 promoter was approx. 61 % below the wild-type CUP1 promoter , thus expanding the 36 absolute range of Cu 2+ -based gene control. The stability of 3vGFP towards direct- 37 repeat recombination was assayed in S. cerevisiae cultured for 25 generations under 38 strong and slightly toxic expression after which only limited reduction in fluorescence 39 was detectable. Such non-recombinogenic GFPs can help quantify intracellular 40 responses operating a low copy number in recombination-prone organisms. 41
Metacognitive Support of Mathematical Abstraction Processes: Why and How - A Basic Reasoning

—A signiﬁcant and distinctive feature of human be- ings is the ability of performing abstraction operations, e.g., when forming categories of objects or even conscioulsy creat- ing abstract objects as it is typical in mathematics. Although the possible range of corresponding abilities is certainly pre- determined by individual genetic factors, a high-level abstraction performance will typically be achieved gradually by an intensive long-run practice in solving abstraction prone problems. On the other hand, mathematical abstraction is often considered to be a serious obstacle in mathematics education. As metacognition has turned out to be helpful in overcoming some other obstacles in the students’ process of knowledge acquisition, one may ask whether metacognition may also serve as a remedy against the abstraction obstacle and, in particular, whether it may help to accelerate the acquisition of abstraction abilities. The paper provides some inital reasoning w.r. t. this possibility, proposes some basic principles of abstraction that could be taught on a metacognitive level, and presents a concept of a corresponding teaching experiment. Hopefully, it will provide more effective teaching as well as a better understanding of cognitive processes underlying mathematical abstraction.