Miracle-dz/UniFAR-FTUs huggingface dataset:
Aggression and Impulsivity in Different Groups of Alcohol and Heroin Dependent Inpatient Men

OZET: Yatarak tedavi goren erkek alkol ve eroin bagimlisi iki grupta agresyon ve durtusellik Amac: Bu calismanin amaci alkol ve eroin bagimliligi olan iki ayri grupta agresyon ve durtuselligin degerlendirilmesidir. Yontem: Calismaya yatarak tedavi goren ardisik 94 alkol bagimlisi ve 78 eroin bagimlisi erkek hasta ile 63 saglikli kontrol alindi. Hastalar ve kontroller Buss-Perry Agresyon Olcegi ve Barratt Durtusellik Olcegi-11 ile degerlendirildi. Bulgular: Alkol ve eroin bagimlilarinda durtusellik ve agresyon duzeyi kontrol grubundan daha yuksek saptandi. Gruplar arasinda farklilik gostermeyen tek alt olcek sozel agresyondu. Agresyon ve durtuselligin siddeti hem alkol bagimlilarini hem de eroin bagimlilarini kontrol grubundan ayirt ediyordu. Agresyon ve durtuselligin alt olcekleri bagimsiz degisken olarak alindiginda yas, dusmanlik ve motor durtuselligin alkol bagimlilarini; fiziksel agresyon ve planlanmamis durtuselliginin eroin bagimlilarini kontrol grubundan ayirt ettigi goruldu. Agresyon ve durtusellik duzeyleri alkol ve eroin bagimlilarini birbiriden ayirt etmemekle birlikte alkol ve eroin bagimlilarinda agresyon ve durtuselligin farkli boyutlari kontrol grubundan ayirt ediciydi. Sonuclar degerlendirilirken calisma grubunun tedavi arayisindaki erkek hastalardan olustugu ve calismanin kesitsel yapisinin durtusellik, agresyon ve bagimlilik arasindaki nedensellik iliskisinin tanimlanmasini engelleyecegi dikkate alinmalidir. Sonuc: Bulgular hem agresyon hem de durtuselligin madde bagimlilarinin tedavisinde odaklanilmasi gereken onemli kavramlar oldugunu ve farkli madde bagimliliklarinda farkli alt boyutlarin dikkate alinmasi gerektigini dusundurmektedir.
A Molecular Genetic Study of Autosomal Recessive Primary Microcephaly in three Pakistani Kindred

Microcephaly (MCPH) is a condition with architecturally normal brain but reduced head of occipito-frontal circumference below -2 or -3 standard deviation. Primary microcephaly is present at birth leading to non-progressive mental retardation, affecting 2-2.5% of the total population and is more prevalent in Asia and Arab than Europe. About 50% indi- viduals with primary microcephaly have an ASPM mutation that is the most common cause of MCPH in Pakistan. In this present study exclusion mapping of three different families of primary microcephaly was done. DNA was isolated from three affected families (MCP1, MCP2 and MCP3) and PCR was followed by non-denaturing polyacrylamide gel electrophoresis. One family MCP1 showed complete linkage with locus 5 (MCPH5) on chromosome 1q31. Second family MCP2 linked at locus 2 on chromosome 19q13.1-13.2 and third family MCP3 did not linked with any of the known locus (MCPH1-MCPH7). The heterozygous pattern of affected individuals was found for MCP3 family during screening of all known loci. This finding suggested the plausibility of a novel locus, so genome wide search of MCP1 family should be supportive in future, which would lead to the mapping of a novel region associated with primary microcephaly.
To what extent does the oral shift report stimulate learning among nursing students? A qualitative study*.

AIM AND OBJECTIVE The aim of this study was to describe oral shift reporting and to discuss whether it stimulates learning for nursing students in clinical rotations in nursing homes. The goal was to investigate aspects that are important for oral shift report to be instructive for nursing students. BACKGROUND Nursing students' clinical learning experiences are important components of their professional development. Oral shift reporting serves several purposes and provides an opportunity for professional communication that supports both educational and social functions for nursing students during clinical practice. DESIGN A qualitative study. METHODS The study features both field work with field notes and qualitative research interviews was conducted in 2006. Twelve third-year nursing students and their supervising nurses (n = 11) participated in the study. RESULTS The nursing students described a range of experiences with oral shift reports. Some perceived little educational benefit from the oral shift reports, while others felt that both the form and the content of the oral shift reports were useful. The students' experiences corroborated the statements provided by the supervising nurses in the nursing homes. CONCLUSIONS We conclude that oral shift reporting may be an important learning opportunity. This is especially true when nursing students engage in professional discussions with their colleagues and superiors. Our findings suggest solutions to improve the learning value of the oral shift reporting process for nursing students. RELEVANCE TO CLINICAL PRACTICE Oral shift reporting can stimulate learning if it includes consultation and discussion between nursing students and the nursing staff.
6-DoF velocity estimation using RGB-D camera based on optical flow

In this paper, we suggest a new 6-DoF velocity estimation algorithm using RGB and depth images. Autonomous control of mobile robots requires their velocity information. There exist numerous researches on estimating and measuring the velocity. However, more investigations are needed related to vision sensors and depth image. In this work, we propose an algorithm for velocity estimation with an RGB-D sensor based on image jacobian matrix usually used in image-based visual servoing. We validate the performance of the proposed estimation algorithm in various environments with the RGB-D benchmark dataset. The velocity estimation results show the high quality of estimated 6-DoF velocity compared to the ground truth velocity.
DNA methylation in 5-aza-2'-deoxycytidine-resistant variants of C3H 10T1/2 C18 cells

A cell line (T17) was derived from C3H 10T1/2 C18 cells after 17 treatments with increasing concentrations of 5-aza-2'-deoxycytidine. The T17 cell line was very resistant to the cytotoxic effects of 5-aza-2'-deoxycytidine, and the 50% lethal dose for 5-aza-2'-deoxycytidine was ca. 3 microM, which was 30-fold greater than that of the parental C3H 10T1/2 C18 cells. Increased drug resistance was not due to a failure of the T17 cell line to incorporate 5-aza-2'-deoxycytidine into DNA. The cells were also slightly cross-resistant to 5-azacytidine. The percentage of cytosines modified to 5-methylcytosine in T17 cells was 0.7%, a 78% decrease from the level of 3.22% in C3H 10T1/2 C18 cells. The DNA cytosine methylation levels in several clones isolated from the treated lines were on the order of 0.7%, and clones with methylation levels lower than 0.45% were not obtained even after further drug treatments. These highly decreased methylation levels appeared to be unstable, and DNA modification increased as the cells divided in the absence of further drug treatment. The results suggest that it may not be possible to derive mouse cells with vanishingly low levels of 5-methylcytosine and that considerable de novo methylation can occur in cultured lines.
Hrr 25 / CK 1-directed release of Ltv 1 from pre-40 S ribosomes is necessary for ribosome assembly and cell growth

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 208 No. 6 745–759 www.jcb. org/cgi/doi/10.1083/jcb.201409056 JCB 745 Correspondence to Katrin Karbstein: kkarbst@scripps.edu Abbreviations used in this paper: 1NA-PP1, 1(1, 1dimethylethyl)3(1naphthalenyl)1Hpyrazolo[3, 4d]pyrimidin4amine; AF, assembly factor; CK1, casein kinase 1; cryo-EM, cryogenic EM; Dox, doxycycline; rRNA, ribosomal RNA. Introduction
A parthenogenetic Varanus

We report on a case of parthenogenesis in the varanid lizard Varanus panoptes . Parthenogenesis was observed in a female kept alone for three years. A clutch was deposited from which a single egg could be secured and incubated. Incubation was successful and a male specimen hatched. Obviously the newborn was produced without contribution of a father. After the unisexual reproduction, the mother was kept with males and bisexual reproduction was observed, too. We performed DNA Fingerprinting and showed that the parthenogen and its mother exhibit almost identical DNA patterns. The bisexually produced offspring has only a subset of bands in common with the mother and another subset in common with the father. Thus DNA Fingerprinting is in accordance with our observations and confims parthenogenesis. We compare our results with existing cytological models of parthenogenesis and point out the following: 1. The mode of parthenogenesis described here is facultative, as the mother was able to reproduce in the bisexual mode as well. 2. The parthenogen is male and hence not a clone of the mother. 3. Almost complete heredity of maternal Fingerprint markers. All these points considered our case seem to fit to no known model of parthenogenesis exactly. But an additional recombination could result homogamety (would explain the sex of the parthenogen) while expressing almost all maternal bands.
The Impact of Automated Office Systems on Middle Managers and Their Work

A survey of seventy-five Montreal middle managers was conducted, investigating their perceptions of the impact of automated office systems on their jobs and work. Two key findings emerged in the results. First, middle managers perceived that office automation had led to a variety of changes that, almost without exception, made their jobs and work more enriching and satisfying. Second, middle managers with first-hand experience with various systems, either through the presence of such systems in their organization or through their own personal use of such systems, were even more positive than managers without this exposure. The importance of these findings is discussed in the context of related work drawn from the fields of psychology and organizational behavior.
The Aspergillus fumigatus chsC and chsG genes encode Class III chitin synthases with different functions

Two genes, designated chsC and chsG were isolated from DNA libraries of the opportunistic fungal pathogen, Aspergillus fumigatus. The genes were characterized with respect to their nucleotide sequences and mutant phenotypes. The complete deduced amino acid sequences of chsC and chsG show that the products of both genes are Class III zymogen‐type enzymes. A mutant strain constructed by disruption of chsC is phenotypically indistinguishable from the wild‐type strain, but chsG− and chsC− chsG− strains have reduced colony radial growth rate and chitin synthase activity, conidiate poorly and produce highly branched hyphae. Despite these defects, the double‐mutant strain retained the ability to cause pulmonary disease in neutropenic mice. However, in comparison to the wild‐type strain, there was a decrease in mortality and delay in the onset of illness in mice inoculated with the double‐mutant strain, which was associated with smaller and more highly branched fungal colonies in lung tissue.
NAEVUS CELLS IN LYMPH NODES

Summary Benign naevus cells were found in lymph nodes resected from 24 patients, mostly from the axilla and less frequently from the groin and neck. None were found in lymph nodes not draining the skin. The cells were always situated in the capsule, and often in the trabeculae of the node. Occasionally they were also found in the walls of lymphatic vessels and sinuses and in one instance also in the parenchyma. Their occurrence was not related to the nature of the malignancy for which the resection was performed, nor was their presence due to any effect produced by the operation. One explanation for their occurrence is that they are a form of benign metastasis of cells adapted to survive in connective tissue.
DIFFUSE INTRACYTOPLASMIC GANGLIONIC INCLUSIONS (LEWY TYPE) ASSOCIATED WITH PROGRESSIVE DEMENTIA AND QUADRIPARESIS IN FLEXION

Intraganglionic inclusion bodies of presumably non-viral ongm have been associated with a range of defined neurologic disturbances, including myoclonus epilepsy (1), Pick's disease (2), and Parkinson's disease (3). In each of these entities the inclusions present a pattern of characteristics (histochemical and histologic properties, topographical distribution and size) which permits a degree of diagnostic differentiation. In the Parkinsonian states, the inclusion is typically intracytoplasmic, and most frequently encountered in the pigmented neurons of the mesencephalic and rhombencephalic nuclei (4). Two elderly patients with progressive dementia associated with quadriparesis in flexion, and without any Parkinsonian stigmata, have been studied, demonstrating at autopsy widely disseminated intracytoplasmic ganglionic inclusions morphologically and histochemically indistinguishable from those initially described by Lewy in Parkinson's disease (paralysis agitans).
Development of a Humanized In Vitro Blood–Brain Barrier Model to Screen for Brain Penetration of Antiepileptic Drugs

Summary: Purpose: A biotechnologic breakthrough for the study of drug permeability across the blood–brain barrier (BBB) would be the use of a reproducible in vitro model that recapitulates the functional, structural, and pathologic properties of the BBB in situ. We developed a humanized dynamic in vitro BBB model (DIV‐BBB) based on cocultures of human microvascular endothelial cells (HBMECs) from “normal” and drug‐resistant epileptic brain tissue with human brain astrocytes (HAs) from epilepsy patients or controls.
Low utilisation of diagnostic microbiology for community acquired pneumonia in regional Victoria

Aims: Diagnostic microbiology for community acquired pneumonia (CAP) provides useful information for patient management, infection control and epidemiological surveillance. Newer techniques enhance that information and the time interval for obtaining results. An audit of diagnostic microbiology utilisation, microbiological aetiology, and influence of results on prescribing practices in CAP in a regional Australian hospital setting was performed. Methods: Clinical, microbiological and outcome data were collected by medical record review of patients discharged from Ballarat Hospital with a diagnosis of CAP over a 12 month period. Results: Of 184 identified CAP episodes, 47 (25.5%) had no diagnostic microbiology performed. Respiratory virus polymerase chain reaction (PCR) was rarely performed (2.7% of all episodes). Acute serology was frequently requested, however paired acute and convalescent serology was infrequently performed (5/75 testing episodes; 6.7%). CAP severity was not correlated with microbiological investigation intensity. The most common pathogens identified were Streptococcus pneumoniae and Mycoplasma pneumoniae (5.4% and 2.2%, respectively). Diagnostic testing appeared to rarely influence antimicrobial prescribing. Conclusions: In this setting, diagnostic microbiological tests such as respiratory virus PCR and urinary antigen tests are under-utilised. In contrast, sputum and serological investigations are commonly requested, however rarely influence practice. Interventions to facilitate efficient usage of diagnostic microbiology are required.
Benefit of Using Multiple Baselines and Multiple Aspects for SAR Interferometry of Urban Areas

In this paper, extensive real-data experiments for the investigation of the benefit of exploiting multiple aspects and multiple baselines for the reconstruction of urban surface models by synthetic aperture radar interferometry are documented. These experiments are carried out within a recently proposed reconstruction framework that allows the fusion of almost arbitrary configurations of multi-aspect multi-baseline InSAR data. The results based on airborne decimeter-resolution millimeterwave imagery prove and quantify that multiple baselines help to solve the phase ambiguity problem, while multiple aspects reduce the parts of the scene affected by radar shadowing. In addition, the inherent redundancy provides a significant improvement in the achievable reconstruction accuracy, which is evaluated relative to the reconstruction error common for conventional single-aspect single-baseline SAR interferometry.
Evaluation of thyroid dysfunction and postpartum depression in the postpartum female

Objective: To explore the potential correlation between postpartum thyroid dysfunction and postpartum depression and devise an appropriate strategy with which to detect and distinguish these conditions. Methods: Research was conducted using the following databases: CINAHL, Dissertation Abstracts, JAMA, NIH, ProQuest Nursing & Allied Health Source, PsycINFO, PsycLIT, and PubMed. Reviewed articles came from peer-reviewed journals and fell within a 12-year time frame. The research population lied within the United States and Europe and articles were written in or translated into English. Results: A direct correlation between postpartum thyroid dysfunction and postpartum depression is yet to be proven, but a distinct overlap of symptoms exists. Conclusion: The role of the clinician in proper diagnosis is essential. The clinician must keep these related diagnoses in mind when caring for patients throughout the postpartum period and utilize the Edinburgh Postnatal Depression Scale with TSH, T3, free T4, and TPO antibody testing when necessary.
Effect of Chordin-Like 1 on MC3T3-E1 and Human Mesenchymal Stem Cells

Since the discovery that bone morphogenetic proteins (BMPs) are able to induce ectopic bone formation, considerable effort has been devoted to apply it for bone regeneration. BMP activity needs to be temporally and spatially controlled and the organism has devised ways to achieve it. Here we show that the BMP inhibitor chordin-like 1 can interfere with BMP2 signalling thereby affecting the osteogenic differentiation of MC3T3-E1 cells. Besides its function as a BMP antagonist, chordin-like 1 enhanced the proliferation of human mesenchymal stem cells (hMSCs) in a BMP2-independent manner. When MC3T3-E1 cells were exposed to recombinant chordin-like 1 there was an inhibition of alkaline phosphatase (ALP) expression, whereas in the case of hMSCs no effect was observed. However, chordin-like 1 dose-dependently increased the proliferation of hMSCs. This effect is probably BMP2 independent because the chordin-like 1 concentration that stimulates proliferation does not interfere with BMP signalling monitored by a Smad-dependent reporter gene. Our data point towards a novel, BMP-independent role of chordin-like 1 in hMSC proliferation.
The insignia system of customized orthodontics.

phy, scanning, and radiology have greatly improved orthodontic diagnostic procedures,1-5 computerized systems that design orthodontic appliances for individual patients represent a more recent breakthrough.6-11 Such systems not only shorten treatment time, making cases more predictable and less labor-intensive,12-14 but allow doctors and patients to preview virtual results before treatment begins, thus facilitating communication, understanding, and cooperation. A customized appliance system uses digital models of the patient’s arches to simulate the optimal position of each dental element and the ideal final occlusion.6-11 Once the desired virtual result is achieved, the personalized archwires, brackets, and indirect-bonding transfer jigs are produced. This article describes the Insignia* system, an advanced, computerized orthodontic technology used to design and fabricate personalized appliances.
China TESTS OF FRICTION ENERGY DISSIPATORS FOR SEISMIC PROTECTION OF BUILDINGS

This paper presents unidirectional shaking table tests of two steel frames; they are reduced scale models of two building structures with one and two floors, respectively. Such frames incorporate friction dissipators at every floor. The inputs are sine-dwells and artificial and registered earthquakes; some of the sine-dwells generate near-resonance motion and some of the earthquakes contain pulses corresponding to near-fault effects. The main objectives of these experiments are: (i) to collect a wide range of results useful to calibrate a numerical model derived by the authors, (ii) to contribute to clarify some of the most controversial issues about friction dissipators (introduction of high frequencies in the response, behavior for inputs containing pulses, capacity to cut resonance peaks, self-generated eccentricities), (iii) to understand better their dynamic behavior, (iv) to give an insight on the feasibility and reliability of using simple friction dissipators for seismic protection of building structures and (v) to characterize the hysteretic behavior of these devices.
Presence of Diabetes-Inhibiting, Glutamic Acid Decarboxylase-Specific, IL-10-Dependent, Regulatory T Cells in Naive Nonobese Diabetic Mice1

Immunization of NOD mice with autoantigens such as glutamic acid decarboxylase (GAD) 221–235 peptide (p221) can induce Ag-specific CD4+ T regulatory (Tr) cells. However, it is unclear whether these Tr cells acquire their regulatory capacity due to immunization or whether they are constitutively harbored in unimmunized naive mice. To address this question, we used an I-Ag7 tetramer to isolate p221-specific T cells from naive NOD mice (N221+ cells) after peptide-specific in vitro expansion. The N221+ T cells produced IFN-γ and IL-10, but very little IL-4, in response to p221 stimulation. These T cells could function as regulatory cells and inhibit in vitro proliferation of diabetogenic BDC2.5 cells. This suppressive activity was cell contact-independent and was abrogated by Abs to IL-10 or IL-10R. Interestingly, IL-2 produced by other T cells present in the cell culture induced unactivated N221+ T cells to exhibit regulatory activities involving production of IL-10. In vivo, N221+ cells inhibited diabetes development when cotransferred with NOD splenocytes into NOD/scid recipients. Together, these results demonstrate that p221-specific IL-10-dependent Tr cells, including Tr type 1 cells, are present in naive NOD mice. The use of spontaneously arising populations of GAD peptide-specific Tr cells may represent a promising immunotherapeutic approach for preventing type 1 diabetes.
Prologue to a Unified Theory of Attitudes , Stereotypes , and Self-concept

The theoretical analysis in this chapter connects social psychology's central cognitive constructs, stereotype and self-concept, to its central affective constructs, attitude and self-esteem. In addition to proposing this unified account of social psychology's major theoretical constructs, the chapter seeks to unify the competing affective-cognitive consistency principles of social psychology's classic consistency theories: Heider's (1958) balance theory, Osgood and Tannenbaum's (1955) congruity theory, and Festinger's (1957) cognitive dissonance theory. Initial support for the unified theory comes from experiments that use a new latency-based procedure, the Implicit Association Test (IAT), to obtain indirect measures of implicit attitudes, stereotypes, self-concept, and self-esteem (Banaji & Greenwald, 1995). The IAT's findings reveal patterns of affective-cognitive consistency that are not readily observed with explicit (self-report) measures.
Molten steel breakout prediction based on genetic algorithm and BP neural network in continuous casting process

In this paper, a compound sticking breakout prediction model including two kinds of modules, the time-sequence module of single thermocouple and the space module of multi-thermocouple was presented. The GA-BP neural network method with the genetic algorithm optimizing the original weights and thresholds of BP neural network, was used for building time-sequence module. Compared with traditional BP neural network, GA-BP neural network could avoid the defects that the results of traditional BP neural network are easily fall into local minimum point, and identify temperature patterns of sticking breakout more accurately. The testing results show the quote rate and accuracy rate for sticking breakout prediction have both achieved 100%.