Miracle-dz/UniFAR-FTUs huggingface dataset:
The Need for Advanced 3D Neural Models and Developing Enabling Technologies

Neurological and psychiatric disorders account for an increasing proportion of the global disease burden. Correspondingly the neuropharmaceutical industry has experienced a significant contraction in recent years resulting in a poor variety of therapies available to treat an expanding range of conditions. Perhaps the greatest contributor to this failure in drug-discovery is the lack of understanding of the underlying biology of the nervous system and how molecular scale events translate into macroscale pathologies. Due to the unique nature of the human nervous system commonly used model organisms are often poorly representative of human pathologies resulting in a need for the development of advanced in vitro models that are capable of faithfully modelling complex structures within the brain. In this review strategies for the generation of neuronal circuits and cultivation of complex three-dimensional cultures are explored. Frequently these constructs provide valuable insights into systems and processes that are difficult to explore in vivo due to the isolated and delicate nature of neuronal tissues however new developments are required to assess the physiological functions of three dimensional tissues in vitro .
Vaccination decreases the risk of influenza A virus reassortment but not genetic variation in pigs

Although vaccination is broadly used in North American swine breeding herds, managing swine influenza is challenging primarily due to the continuous evolution of influenza A virus (IAV) and the ability of the virus to transmit among vaccinated pigs. Studies that have simultaneously assessed the impact of vaccination on the emergence of IAV reassortment and genetic variation in pigs are limited. Here, we directly sequenced 28 bronchoalveolar lavage fluid (BALF) samples collected from vaccinated and unvaccinated pigs co-infected with H1N1 and H3N2 IAV strains, and characterized 202 individual viral plaques recovered from 13 BALF samples. We identified 54 reassortant viruses that were grouped in 17 single and 16 mixed genotypes. Notably, we found that prime-boost vaccinated pigs had less reassortant viruses than nonvaccinated pigs, likely due to a reduction in the number of days pigs were co-infected with both challenge viruses. However, direct sequencing from BALF samples revealed limited impact of vaccination on viral variant frequency, evolutionary rates, and nucleotide diversity in any IAV coding regions. Overall, our results highlight the value of IAV vaccination not only at limiting virus replication in pigs but also at protecting public health by restricting the generation of novel reassortants with zoonotic and/or pandemic potential.
Capturing the Recognition Dynamics of para-Sulfonato-calix[4]arenes by Cytochrome c: Toward a Quantitative Free Energy Assessment

Calix[n]arenes' selective recognition of protein surfaces covers a broad range of timely applications, from controlling protein assembly and crystallization to trapping partially disordered proteins. Here, the interaction of para-sulfonated calix-[4]-arenes with cytochrome c is investigated through all-atom, explicit water molecular dynamics simulations which allow characterization of two binding sites in quantitative agreement with experimental evidence. Free energy calculations based on the MM-PBSA and the attach-pull-release (APR) methods highlight key residues implicated in the recognition process and provide binding free energy results in quantitative agreement with isothermal titration calorimetry. Our study emphasizes the role of MD simulations to capture and describe the "walk" of sulfonated calix-[4]-arenes on the cytochrome c surface, with the arginine R13 as a pivotal interacting residue. Our MD investigation allows, through the quasi-harmonic multibasin (QHMB) method, probing an allosteric reinforcement of several per-residue interactions upon calixarene binding, which suggests a more complex mode of action of these supramolecular auxiliaries.
Fluoro‐recognition: New in vivo fluorescent assay for toluene dioxygenase probing induction by and metabolism of polyfluorinated compounds

Abstract The present study examined the regulatory and metabolic response of the aromatic degrader Pseudomonas putida F1 and its tod operon, controlling toluene degradation, to fluorinated aromatic and aliphatic compounds. The tod operon is upregulated by inducer binding to the TodS sensing domain of a two‐component regulator. The induced enzymes include toluene dioxygenase that initiates catabolic assimilation of benzenoid hydrocarbons. Toluene dioxygenase was shown to oxidize 6‐fluoroindole to a meta‐stable fluorescent product, 6‐fluoroindoxyl. The fluorescent output allowed monitoring relative levels of tod operon induction in whole cells using microtiter well plates. Mono‐ and polyfluorinated aromatic compounds were shown to induce toluene dioxygenase, in some cases to a greater extent than compounds serving as growth substrates. Compounds that are oxidized by toluene dioxygenase and undergoing defluorination were shown to induce their own metabolism. 1,2,4‐Trifluorobenzene caused significant induction and computational modelling indicated productive binding to the TodS sensor domain of the TodST regulator. Toluene dioxygenase also showed preferential binding of 1,2,4‐trifluorobenzene such that defluorination was favoured. Fluorinated aliphatic compounds were shown to induce toluene dioxygenase. An aliphatic ether with seven fluorine atoms, 1,1,1,2‐tetrafluoro‐2‐trifluoromethoxy‐4‐iodobutane (TTIB), was an excellent inducer of toluene dioxygenase activity and shown to undergo transformation in cultures of P. putida F1.
An Efficient Linear Precoding Scheme Based on Block Diagonalization for Multiuser MIMO Downlink System

Block diagonalization (BD) based on singular value decomposition (SVD) is a well-known precoding method that eliminates inter user interference in multiuser multi-input multi-output (MIMO) broadcast channels, but it is computationally inefficient. In this paper we examine the use of generalized singular value decomposition (GSVD) for coordinated beam-forming in MIMO systems. GSVD facilitates joint decomposition of a class of matrices from source to destination MIMO broadcast scenarios. GSVD allows two channels of suitable dimensionality to be jointly diagonalized, through the use of jointly determined transmit precoding and receiver reconstruction matrices. Simulation results demonstrate that the proposed GSVD technique achieves considerable gains in terms of bit error rate (BER) over SVD technique with traditional interference aware block diagonalization (BD) scheme. Analysis and simulation results show that our proposal has lower complexity than the conventional BD method, with a significant increase there in sum throughput.
EEG Dynamics of Locomotion and Balancing: Solution to Neuro-Rehabilitation

The past decade has witnessed tremendous growth in analyzing the cortical representation of human locomotion and balance using Electroencephalography (EEG). With the advanced developments in miniaturized electronics, wireless brain recording systems have been developed for mobile recordings, such as in locomotion. In this review, the cortical dynamics during locomotion are presented with extensive focus on motor imagery, and employing the treadmill as a tool for performing different locomotion tasks. Further, the studies that examine the cortical dynamics during balancing, focusing on two types of balancing tasks, ie, static and dynamic, with the challenges in sensory inputs and cognition (dual-task), are presented. Moreover, the current literature demonstrates the advancements in signal processing methods to detect and remove the artifacts from EEG signals. Prior studies show the electrocortical sources in the anterior cingulate, posterior parietal, and sensorimotor cortex was found to be activated during locomotion. The event-related potential has been observed to increase in the fronto-central region for a wide range of balance tasks. The advanced knowledge of cortical dynamics during mobility can benefit various application areas such as neuroprosthetics and gait/balance rehabilitation. This review will be beneficial for the development of neuroprostheses, and rehabilitation devices for patients suffering from movement or neurological disorders.
Respiratory symptoms in post-infancy children

Aim: To study the pattern of respiratory symptoms in children in the general population. Method: We followed a cohort of children for up to 2 years through parents completing weekly online questionnaires in the Child-Is-Ill study (“Kind-en-Ziekmeting” in Dutch); the study was running 2012–2015. Inclusion criteria were “an ordinary child” (according to the parents) and < 18 years old at inclusion. We especially encouraged participation of post-infancy children. Age at inclusion, sex, smoking exposure, allergy in the family, and frequent infections in the family were noted. Pearson’s correlation, principal component analysis, latent class analysis, latent proﬁle analysis, linear regression, and linear mixed effects regression were used in the statistical analyses. Results: Data were collected on 55,524 childweeks in 755 children (50% girls; median age, 7 years; interquartile range, 4–11 years, 97% ≥ 2 years at inclusion), with reported symptom(s) in 8,425 childweeks (15%), leading to school absenteeism in 25%, doctor’s visits in 12%, and parental sick leave in 8%; symptoms lasting ≥ 3 weeks were rare (2% of episodes). Linear mixed effects regression showed signiﬁcant, but only limited, effects of season on the proportion of “symptom(s) reported” per individual child. Only runny nose showed a signiﬁcant, but very small, age effect. However, the variability between the children was considerable. There were no obvious subgroups of children with speciﬁc symptom combinations. Conclusion: In any randomly chosen week, the vast majority of children (85%) in our—mainly—post-infancy cohort derived from the general population did not have any symptom, even in the younger age group, even in winter. The children showed considerable variability; no clear subgroups of symptom patterns could be identiﬁed, underlining the difﬁcult position of healthcare providers. These results support our opinion that post-infancy children in the general population should not be evaluated as if they are infants when they have recurrent respiratory symptoms. If they clearly deviate from the above-described most common pattern, it is wise to keep an eye on potential, maybe even rare, serious underlying causes.
The Use of Blended Diets in Children With Enteral Feeding Tubes: A Joint Position Paper of the ESPGHAN Committees of Allied Health Professionals and Nutrition

Objectives: This joint position paper of the Committees of Allied Health Professionals (CAHP) and Nutrition (CON) of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) provides a comprehensive guide for health professionals to manage blended diets in children via gastrostomy tubes. Methods: A systematic literature search was performed from 1992 to 2021 using Pubmed, MEDLINE, and Cochrane Database of Systematic Reviews and recent guidelines reviewed. In the absence of evidence, recommendations reflect the authors’ expert opinion. Final consensus was obtained by multiple e-mail exchange and virtual meetings of the CAHP and CON. Results: Reported benefits of blended diets include reduced GERD and infections, improved defecation, level of alertness and attention span, skin conditions, and appearance of hair and nails. Families report a sense of greater normality. Small case series, cross-sectional surveys, questionnaire-based small case studies, reports of personal experience, and single-center pilot studies are available in the medical literature. A total of 20 recommendations for practice were made based on the results and consensus process. Conclusions: There is little evidence published to formally inform about the potential health benefits or risks of this practice and how to use it in the best way. This leaves health professionals caring for such patients in a relative vacuum regarding what to consider when providing a duty of care to patients and carers who wish to pursue this method of feeding. This article provides guidelines for safe and appropriate use of a BD, but more research is needed.
Noise-induced differences in the complexity of spoken language

Although speaking in noisy environments is a common occurrence, few studies have investigated how noise affects language production beyond the acoustic level. In seeking to differentiate between speaker- and listener-oriented modifications, this study examines the effect of noise on the complexity of language production and examines whether cognitive control predicts noise-induced modifications. Participants completed a picture description task via videoconferencing software while both the speaker (the participant) and listener (the experimenter) were exposed to multi-talker babble. Speakers produced fewer T-units, clauses, and words as well as fewer, but longer, unfilled pauses in noise. The degree of reduction in number of clauses, words, and unfilled pauses was significantly associated with weaker cognitive control. Thus, we consider these modifications to be speaker-oriented, driven by the distracting nature of noise. However, participants also produced fewer filled pauses and mazes in noise. These modifications were not significantly correlated with cognitive control, and they diverge from prior work demonstrating that speakers tend to produce more disfluencies when they alone shoulder the burden of a noisy environment. This pattern of results suggests that speakers may alter their speech to alleviate cognitive burden on themselves as well as to facilitate comprehension for their listener.
Group dynamic-relational therapy for perfectionism

The interest in treating underlying core vulnerability factors or transdiagnostic processes has been a focus of much attention. In this paper we describe our application of group dynamic-relational psychotherapy to the treatment of perfectionism, a core personality vulnerability factor associated with various forms and types of dysfunction and disorders that have profound costs to the individual both socially and subjectively. Over the course of the past three decades, we developed an evidence-based integrative group treatment that targets the psychodynamic and relational underpinnings of perfectionism. The treatment is based on an integration of psychodynamic and interpersonal perspectives and therapeutic approaches. In this paper we present our model of perfectionism and describe our group dynamic-relational therapy for the treatment of its pernicious outcomes. By drawing on illustrative case material, we describe the approach as applied to one such group as it progresses through four phases of group development that we have termed engagement and pseudo attachment, pattern interruption, self-redefinition/painful authenticity, and termination. Finally, we present some of the accumulating evidence of the effectiveness and efficacy of dynamic- relational therapy.
Enhanced Dorsal Attention Network to Salience Network Interaction in Video Gamers During Sensorimotor Decision-Making Tasks

Video game playing is most often a perceptually and cognitively engaging activity. Players enter into sensory rich competitive environments, which require them to go from trivial tasks to active decisions repeatedly and could lend themselves to improve sensorimotor decision-making capabilities. Since video game playing requires moment-to-moment switching of attention from one aspect of sensory information and task to another, enhanced attention control and attention-switching mechanism in the brain can be thought to be the neural basis for such improvements. Previous studies have suggested that attention-switching is mediated by the salience network (SN). However, how SN interacts with the dorsal attention network (DAN) in active decision-making tasks and whether video-game playing modulate these networks remain to be investigated. Using a modified version of the left-right moving dots motion task in a functional magnetic resonance imaging (fMRI) experiment, we examined the decision response times (dRT) and associated functional interactions within and between SN and DAN for video game players (VGP) and non-video game players (NVGP). We found that VGP had an overall lower response time for all task conditions and a higher decision accuracy for a medium speed setting of moving dots. Associated with this improved task performance in VGP compared with NVGP was an increase in DAN to SN connectivity. This SN-to-DAN connectivity was negatively correlated with dRT. These results suggest that enhanced DAN's influence over SN is a part of the brain basis for improved sensorimotor decision-making performance as a result of engaging long term in cognitively challenging and attention demanding activities like video-game playing.
Porous but Mechanically Robust All-Inorganic Antireflective Coatings Synthesized using Polymers of Intrinsic Microporosity.

Here, we introduce polymer of intrinsic microporosity 1 (PIM-1) to design single-layer and multilayered all-inorganic antireflective coatings (ARCs) with excellent mechanical properties. Using PIM-1 as a template in sequential infiltration synthesis (SIS), we can fabricate highly uniform, mechanically stable conformal coatings of AlOx with porosities of ∼50% and a refractive index of 1.41 compared to 1.76 for nonporous AlOx that is perfectly suited for substrates commonly used in high-end optical systems or touch screens (e.g., sapphire, conductive glass, bendable glass, etc.). We show that such films can be used as a single-layer ARC capable of reduction of the Fresnel reflections of sapphire to as low as 0.1% at 500 nm being deposited only on one side of the substrate. We also demonstrate that deposition of the second layer with higher porosity using block copolymers enables the design of graded-index double-layered coatings. AlOx structures with just two layers and a total thickness of less than 200 nm are capable of reduction of Fresnel reflections under normal illumination to below 0.5% in a broad spectral range with 0.1% reflection at 700 nm. Additionally, and most importantly, we show that highly porous single-layer and graded-index double-layered ARCs are characterized by high hardness and scratch resistivity. The hardness and the maximum reached load were 7.5 GPa and 13 mN with a scratch depth of about 130 nm, respectively, that is very promising for the structures consisting of two porous AlOx layers with 50% and 85% porosities, correspondingly. Such mechanical properties of coatings can also allow their application as protective layers for other optical coatings.
Introduction to Global Optimization (Nonconvex Optimization and Its Applications)

Introduction to help the material including, algorithms applications. Global optimization global is no, other words if tt called maximal when there. Global optimization the first textbook on methods computation and lipshitz problems decomposition. 'mathematical reviews 96g the first comprehensive textbook on optimization focus on. Global optimization each chapter contains illlustrative examples and exercises.
A Hierarchical Attention Network for Cross-Domain Group Recommendation

Many online services allow users to participate in various group activities such as online meeting or group buying, and thus need to provide user groups with services that they are interested. The group recommender systems (GRSs) emerge as required and provide personalized services for various online user groups. Data sparsity is an important issue in GRSs, since even fewer group–item interactions are observed. Moreover, the group and the group members have complex and mutual relationships with each other, which exacerbates the difficulty in modeling the preferences of both a group and its members for recommendation. The cross-domain recommender system (CDRS) is a solution to alleviate data sparsity and assist preference modeling by transferring knowledge from a source domain which has relatively dense data to another. The existing CDRSs are usually developed for individual users and cannot be directly applied for group recommendation. To alleviate the data sparsity issue in GRSs, we first study the cross-domain group recommendation problem and propose a hierarchical attention network-based cross-domain group recommendation method, called HAN-CDGR. HAN-CDGR takes the advantage of data from a source domain to benefit recommendation generation for both the individual users and groups in the target domain which has data sparsity and cannot generate accurate recommendation. In HAN-CDGR, a hierarchical attention network is constructed to learn and model individual and group preferences, with consideration of both group members’ interactions and dynamic weights and the complex relationships between individuals and groups. Adversarial learning is used to effectively transfer knowledge from a source domain to the target domain. Extensive experiments, which demonstrate the effectiveness and superiority of our proposal, providing accurate recommendation for both individual users and groups, are conducted on three tasks.
Selenium supplementation for polycystic ovary syndrome: a meta-analysis of randomized controlled trials

Abstract Introduction: The efficacy of selenium supplementation was elusive for polycystic ovary syndrome. This meta-analysis aimed to explore the efficacy of selenium supplementation for polycystic ovary syndrome. Methods: PubMed, EMbase, Web of science, EBSCO, Cochrane library database, CNKI, Chongqing VIP database and Wanfang databases have been searched through July 2022 and we included randomized controlled trials (RCTs) reporting the effect of selenium supplementation versus placebo in patients with polycystic ovary syndrome. Results: Five RCTs were included in the meta-analysis. Compared with placebo group for polycystic ovary syndrome, selenium supplementation was associated with significantly reduced total testosterone (SMD=-0.42; 95% CI=-0.78 to −0.06; p = 0.02) and cholesterol (SMD=-0.71; 95% CI=-1.41 to −0.02; p = 0.04), but revealed no remarkable influence on SHBG (SMD=-0.52; 95% CI=-1.29 to 0.25; p = 0.19), triglyceride (SMD=-1.45; 95% CI=-3.62 to 0.73; p = 0.19), LDL (SMD=-0.17; 95% CI=-0.72 to 0.37; p = 0.53), FPG (SMD=-0.95; 95% CI=-3.72 to 1.82; p = 0.50) or HOMA-IR (SMD=-0.51; 95% CI=-3.79 to 2.77; p = 0.76). Conclusions: Selenium supplementation may be able to improve the metabolic response for polycystic ovary syndrome, and this finding should be interpreted with caution.