Miracle-dz/UniFAR-FTUs huggingface dataset:
Organometallic Compounds and Metal Complexes in Current and Future Treatments of Inflammatory Bowel Disease and Colorectal Cancer—a Critical Review

In recent years, there has been a significant increase in the clinical use of organometallic compounds and metal complexes for therapeutic purposes including treatment of inflammatory bowel diseases (IBD). Their action is based on the inhibition of the inflow of pro-inflammatory cytokines, the elimination of free radicals or the modulation of intestinal microbiota. In addition, these compounds are intended for use in the diagnosis and treatment of colorectal cancer (CRC) which is often a consequence of IBD. The aim of this study is to critically discuss recent findings on the use of organometallic compounds and metal complexes in the treatment of IBD and CRC and suggest future trends in drug design.
For Better or Worse: The Potential for Dose Limiting the On-Target Toxicity of PI 3-Kinase Inhibitors

The hyper-activation of the phosphoinositide (PI) 3-kinase signaling pathway is a hallmark of many cancers and overgrowth syndromes, and as a result, there has been intense interest in the development of drugs that target the various isoforms of PI 3-kinase. Given the key role PI 3-kinases play in many normal cell functions, there is significant potential for the disruption of essential cellular functions by PI 3-kinase inhibitors in normal tissues; so-called on-target drug toxicity. It is, therefore, no surprise that progress within the clinical development of PI 3-kinase inhibitors as single-agent anti-cancer therapies has been slowed by the difficulty of identifying a therapeutic window. The aim of this review is to place the cellular, tissue and whole-body effects of PI 3-kinase inhibition in the context of understanding the potential for dose limiting on-target toxicities and to introduce possible strategies to overcome these.
Association between Psychosocial Stress and Cardiovascular Disease in Relation to Low Consumption of Fruit and Vegetables in Middle-Aged Men

Stress has been reported to affect dietary intake and chronic disease. This study aimed to investigate the association between psychosocial stress and cardiovascular disease (CVD) in relation to dietary intake. This cross-sectional analysis was performed on 23,792 men enrolled in the Korean Genome and Epidemiology Study from 2004 to 2013. Stress was assessed by the Psychosocial Well-Being Index. Stress level was positively associated with the risks of CVD (odds ratio (OR) for quartile 4 compared to quartile 1 = 1.30 (95% confidence interval 1.24–1.37), p-trend < 0.0001), including hypertension (OR = 1.26 (1.20–1.33), p-trend < 0.0001), heart disease (OR = 1.55 (1.34–1.80), p-trend = 0.0001), and cerebrovascular disease (OR = 2.47 (1.97–3.09), p-trend < 0.0001). As the level of stress increased, the intake of fruits and vegetables, as well as antioxidant nutrients, was decreased. Stress level showed an inverse association with dietary variety score (p-trend = 0.0001). In addition, dietary variety score was inversely associated with fruits and vegetables consumption (p-trend < 0.0001). These results suggest that the CVD risks for those with higher stress levels may be partially related to the decreased consumption of fruits and vegetables and dietary variety score.
No evidence for cell‐to‐cell transmission of the unfolded protein response in cell culture

The unfolded protein response (UPR) is one of the major cell‐autonomous proteostatic stress responses. The UPR has been implicated in the pathogenesis of neurodegenerative diseases and is therefore actively investigated as therapeutic target. In this respect, cell non‐autonomous effects of the UPR including the reported cell‐to‐cell transmission of UPR activity may be highly important. A pharmaca‐based UPR induction was employed to generate conditioned media (CM) from CM‐donating neuronal (‘donor’) cells (SK‐N‐SH and primary mouse neurons). As previously reported, upon subsequent transfer of CM to naive neuronal ‘acceptor’ cells, we confirmed UPR target mRNA and protein expression by qPCR and automated microscopy. However, UPR target gene expression was also induced in the absence of donor cells, indicating carry‐over of pharmaca. Genetic induction of single pathways of the UPR in donor cells did not result in UPR transmission to acceptor cells. Moreover, no transmission was detected upon full UPR activation by nutrient deprivation or inducible expression of the heavy chain of immunoglobulin M in donor HeLa cells. In addition, in direct co‐culture of donor cells expressing the immunoglobulin M heavy chain and fluorescent UPR reporter acceptor HeLa cells, UPR transmission was not observed. In conclusion, carry‐over of pharmaca is a major confounding factor in pharmaca‐based UPR transmission protocols that are therefore unsuitable to study cell‐to‐cell UPR transmission. In addition, the absence of UPR transmission in non‐pharmaca‐based models of UPR activation indicates that cell‐to‐cell UPR transmission does not occur in cell culture.
Validity of Wrist-Worn Activity Trackers for Estimating VO2max and Energy Expenditure

Activity trackers are a simple and mostly low-priced method to capture physiological parameters. Despite the high number of wrist-worn devices, there is a lack of scientific validation. The purpose of this study was to assess whether the activity trackers represent a valid alternative to gold-standard methods in terms of estimating energy expenditure (EE) and maximum oxygen uptake (VO2max). Twenty-four healthy subjects participated in this study. In total, five commercially available wrist-worn devices were tested with regard to their validity of EE and/or VO2max. Estimated values were compared with indirect calorimetry. Validity of the activity trackers was determined by paired sample t-tests, mean absolute percentage errors (MAPE), Intraclass Correlation Coefficient, and Bland-Altman plots. Within the tested devices, differences in scattering in VO2max and EE could be observed. This results in a MAPE > 10% for all evaluations, except for the VO2max-estimation of the Garmin Forerunner 920XT (7.3%). The latter significantly underestimates the VO2max (t(23) = –2.37, p = 0.027), whereas the Garmin Vivosmart HR significantly overestimates the EE (t(23) = 2.44, p = 0.023). The tested devices did not show valid results concerning the estimation of VO2max and EE. Hence, the current wrist-worn activity trackers are most likely not accurate enough to be used for neither purposes in sports, nor in health care applications.
Maternal Haplotypes in DHFR Promoter and MTHFR Gene in Tuning Childhood Acute Lymphoblastic Leukemia Onset-Latency: Genetic/Epigenetic Mother/Child Dyad Study (GEMCDS)

Childhood acute lymphoblastic leukemia (ALL) peaks around age 2–4, and in utero genetic epigenetic mother-fetus crosstalk might tune ALL onset during childhood life. Folate genes variably interact with vitamin status on ALL risk and prognosis. We investigated DHFR and MTHFR gene variants in 235 ALL children and their mothers to disclose their role in determining ALL onset age and survival. Pyrosequence of DHFR 19bp ins/del (rs70991108; W/D), MTHFR C677T (rs1801133; C>T), and MTHFR A1298C (rs1801131; A>C) was assessed in children and in 72% of mothers for dyad-analysis comparison. DHFR DD-children had delayed ALL onset compared to WW-children (7.5 ± 4.8 vs. 5.2 ± 3.7 years; P = 0.002) as well as MTHFR 1298 CC-children compared to AA-children (8.03 ± 4.8 vs. 5.78 ± 4.1 years; P = 0.006), and according to the strong linkage disequilibrium between MTHFR 677 T-allele and 1298C-allele, MTHFR TT-children showed early mean age of onset though not significant. Offspring of MTHFR 677 TT-mothers had earlier ALL onset compared to offspring of 677 CC-mothers (5.4 ± 3.3 vs. 7 ± 5.3 years; P = 0.017). DHFR/MTHFR 677 polymorphism combination influenced onset age by comparing DD/CC vs. WW/TT children (8.1 ± 5.7 vs. 4.7 ± 2.1 years; P = 0.017). Moreover, mother-child genotype combination gave 5.5-years delayed onset age in favor of DD-offspring of 677 CC-mothers vs. WW-offspring of 677 TT-mothers, and it was further confirmed including any D-carrier children and any 677 T-carrier mothers (P = 0.00052). Correction for multiple comparisons maintained statistical significance for DHFR ins/del and MTHFR A1298C polymorphisms. Unexpectedly, among the very-early onset group (<2.89 years; 25th), DD-genotype inversely clustered in children and mothers (4.8% vs. 23.8% respectively), and accordingly ALL offspring of homozygous DD-mothers had increased risk to have early-onset (adjusted OR (odds ratio) = 3.08; 1.1–8.6; P = 0.03). The opposite effect DHFR promoter variant has in tuning ALL onset-time depending on who is the carrier (i.e., mother or child) might suggest a parent-origin-effect of the D-allele or a two-faced epigenetic role driven by unbalanced folate isoform availability during the in-utero leukemogenesis responsible for the wide postnatal childhood ALL latency.
Prevalence of tooth wear among Libyan dental students in Benghazi

Background: The problem of tooth wear (TW) encountered increasingly by clinicians and researchers. An early recognition as well as an understanding of the etiologies and risk factors of tooth wear is important to prevent serious irreversible damage to the dentition and for the adequate provision of preventive and therapeutic measures. Aims: To determine the prevalence of tooth wear and identify the associated factors among dental students in Faculty of Dentistry, University of Benghazi. Methods: The study comprised of 300 participants aged 18-27 years, of which 250 (83%) were females and 50 (17%) were males. All participants completed a questionnaire before examination. The questionnaire consisting of 14 questions about dietary habits, hygiene habits, medications usage, tooth sensitivity and para-functional habits. Tooth wear was measured using Smith and Knight Tooth wear Index. Data were tabulated and analyzed using Chi Square test; P value was set at 0.05. Results: The prevalence of tooth wear was 87%. Score 1 was the prevalent score. Lower anterior teeth were the most commonly affected teeth. TW is more frequent in males than females. Significant associations were found between TW and Drinking of coffee, Nescafe, and black tea (p=0.048), biting on hard objects (p=0.039), and subjective xerostomia (p=0.010). Conclusion: Tooth wear is a prevalent condition in this population group. Data supports an association between TW and consumption of hot drinks, biting on hard objects, and xerostomia. Although of many factors investigated in this study, the majority of tooth wear remaining unexplained and further large-scale studies are recommended.
Management Towards a Social-Resource-Based View ( SRBV )

The purpose of this work is to insert the social dimension into the Resourced-Based View (RBV) in order to construct a Social-Resouce-Based View (SRBV.) The method used follows a qualitative exploratory emphasis, which unit of analysis refers to the management action for the development of social innovations in Brazilians Living Labs. Data collection is based on semi-structured interviews with officers in Living Labs. The relationship between Living Labs with social innovation is studied building on RBV extension named Natural-ResouceBased View (NRBV.) According to the reference cited in this article, there are many articles that explore the notion of social resources and their management. In this way, they overcome three theoretical limitations; first limitation is the resource management to become a source of sustainable competitive advantage, in this case it is derived from relationships and joint integration of complementary resources. The second limitation is the connection formed between the social innovation with RBV. The last limitation is the notion of resource orchestration. The RBV reassembles facing the inclusion of the social dimension by proposing a conceptual framework of a SRBV which is composed of three interconnected strategies: social and ethical performance, social innovation and sustainable development. 2 | P a g e Mega Journal of Business Research It also suggests the creation of knowledge of RBV that extends beyond the manipulated motives related to the social innovation.
The Newton power flow method for unbalanced three-phase distribution networks

A general framework is given for applying the Newton-Raphson method to solve three-phase power flow problems, using power and current-mismatch functions in polar, Cartesian coordinates and complex form. These two mismatch functions and three coordinates, result in six versions of the Newton-Raphson method. A three-phase power flow formulation of all versions is described for PQ-buses and PV-buses. This framework enables us to compare all variants theoretically. Furthermore, the convergence behavior is investigated by numerical experiments. Newly developed/improved versions of the Newton power flow method are compared with the BackwardForward Sweep based algorithm. We conclude that the polar current-mismatch and Cartesian current-mismatch versions that are developed in this paper, performed the best result for both balanced and unbalanced distribution networks.
Optimal control of a planar robot manipulator based on the Linear Quadratic Inverse-Dynamics design

To ensure the correct positioning of the end-effector of robot manipulators is one of the most important objectives of the robotic systems control. Lack of reliability in track the reference trajectory, as well as in the desired final positioning compromises the quality of the task to be performed, even causing accidents. The purpose of this work was to propose an optimal controller with an inner loop based on the dynamic model of the manipulator and a feedback loop based on the Linear Quadratic Regulator, in order to ensure that the end effector is in the right place, at the right time. The controller was compared to the conventional PID, presenting better performance, both in the transient response, eliminating overshoot, and steady state, eliminating stationary error.
Performance of Red Tilapia ( Oreochromis sp . ) Fed Diet with Fermented Banana ( Musa Acuminata × Balbisiana ) Peel at Different Stages of Ripeness Following Aeromonas Hydrophila Infection

This study evaluated the dietary effect of fermented banana (Musa acuminata × balbisiana) peel at different stages of ripeness on growth, antioxidant capacity, metabolic response and survival of Red tilapia (Oreochromis sp.) reared for nine weeks following Aeromonas hydrophila infection. The fermented banana peel (FBP) with 100 ml DW was sprayed unto one kg of commercial tilapia feed; 200 ml immature FBP (iFBP), 200 ml ripe FBP (rFBP), 200 ml over ripe FBP (oFBP), while 300 ml DW for the control diet (C). Significant effects of treatments on growth were observed from 3rd to 9th week of rearing. Final weight, specific growth rate and protein efficiency ratio of oFBP-fish were significantly higher and FCR was significantly lower than that of C-fish. WG of oFBP, rFBP, iFBP-fish was increased by 80%, 43% and 29% than that of C-fish, respectively. On the other hand, disregarding ripeness, percentage survival of FBP-fish was significantly higher than that of C-fish after nine weeks of rearing. SOD of oFBP, rFBP and iFBPfish was decreased by 59, 43 and 35 % as compared to that of C, respectively. GPx and GR activity of oFBP-fish were higher than that of the C-+fish. oFBP and rFBP-fish had 52 and 44 % lower Gluc level as compared to that of C-fish, respectively while Lac level of oFBP-fish was lower than that of C-fish. However, no significant difference was found on Trigs. Interestingly, all FBP-fed groups exhibited higher percentage survival than that of C-fish group and the highest post-challenge survival (70%) was recorded in the oFBP-fish group. Disregarding ripeness, higher extrapolated fish yield per 1000 m2 was obtained in FBP-fish than that of C-fish, oFPB>rFBP>oFBP>C while the results for cost-benefit ratio was as follow: oFBP<rFBP<oFBP<C. Overall, these results indicated that FBP at different stages of ripeness, especially oFBP enhances growth performance, stabilizes both antioxidant capacity and metabolic response, improves resistance of Red tilapia against A. hydrophila infection and provides better cost-benefit ratio. FBP could be therefore considered as potential alternative to synthetic growth promoter and antioxidant products used in aquaculture industry.
PADA KERANGKA KERJA TRAKING-LEARNING-DETECTION ( TLD ) ( PARAMETER ANALYSIS OF SCALE AND SHIFT FOR OBJECT DETECTOR IN THE TRACKING-LEARNING-DETECTION ( TLD ) FRAMEWORK )

Learning on TLD is one process that differentiates TLD with other object tracking method. Learning process occurs when the object observed in a video occurs out-of-view or occlusion occurs, when the object will reappear it will be detected again as the object being observed. To represent the observed objects geometric shapes are used, such as bounding boxes. This shape is measured by scale, rotation, and shift of object location. Therefore, analysis of scale and shift parameters is performed. TLD system is given input in the form of image sequences and given the value of scale parameters and shift parameters that have been determined. Next is initialized to an object that is represented in the bounding box of the first frame. After the TLD system has been completed, then the output obtained in the form of image sequences that already exist bounding box, and the point bounding box value. The result of this final project is represented in the form of one-pass evaluation graph (OPE) which shows the result of performance parameter, that is success plot and precision plot. Overall, the best plot and precision plot values are obtained at the value of the 0.5 scale parameter and the parameter value of shift 10 which means, the smaller the value of the scale parameter and the shift parameter value the better the performance.
Automatic Music Transcription and Ethnomusicology: a User Study

Converting an acoustic music signal into music notation using a computer program has been at the forefront of music information research for several decades, as a task referred to as automatic music transcription (AMT). However, current AMT research is still constrained to system development followed by quantitative evaluations; it is still unclear whether the performance of AMT methods is considered sufﬁcient to be used in the everyday practice of music scholars. In this paper, we propose and carry out a user study on evaluating the usefulness of automatic music transcription in the context of ethnomusicology. As part of the study, we recruited 16 participants who were asked to transcribe short musical excerpts either from scratch or using the output of an AMT system as a basis. We collect and analyze quantitative measures such as transcription time and effort, and a range of qualitative feedback from study participants, which includes user needs, criticisms of AMT technologies, and links between perceptual and quantitative evaluations on AMT outputs. The results show no quantitative advantage of using AMT, but important indications regarding appropriate user groups and evaluation measures are provided.
European Conference on Information Systems ( ECIS ) 2002 Measuring the eCommerce Customer Service Lifecycle

This paper describes the preliminary conceptual development of an instrument to measure the ability of an e-commerce site to meet the service aspects of the Customer Service Life Cycle (CSLC) through the use of information technology (IT). In light of the emergence of e-commerce, there is a pressing need for the evaluation of IT-supported services from a customer service perspective. The CSLC purports to be a source of competitive advantage through the differentiation of service offerings (Ives and Learmonth 1984). The CSLC framework can also serve as a basis for the strategic development of interorganizational IT applications. While the CSLC has been discussed in the information systems literature since 1984, little empirical work has been done to develop measures of its constructs of interest
Natural gas consumption and economic growth in Iran

The causality relationship between economic growth and natural gas consumption was investigated using the ARDL (autoregressive distributed lag bounds) testing approach for the 1975 to 2011 period in Iran. Our results show that variables are cointegrated for long run relationship. The results indicate that natural gas consumption, capital formation, employment, financial development, exports are contributing factors to domestic production and hence economic growth in Iran. The unidirectional causality is also found between gas consumption, capital formation and exports to economic growth. The causality analysis indicates that feedback hypothesis is validated between gas consumption and economic growth which indicates that adoption of energy conservation policies should be discouraged. Key-Words: Natural gas consumption, Economic growth, Export, Iran, ARDL
3. SITE 1075

Principal results: Site 1075 is the deep-water drill site on a depth transect in the Lower Congo Basin. It is located in 2995-m deep water in a complex environment dominated by (1) freshwater input from the Congo River, (2) seasonal coastal upwelling and associated filaments and eddies moving offshore, and (3) incursions of open-ocean waters, especially from the South Equatorial Countercurrent. We expect a close tie-in of climatic records from the continent and the ocean in this area. In the fan-margin deposits, the intercalation of pelagic and terrigenous information provides an excellent opportunity for studying cross-correlations of climatic effects on land and at sea. Site 1075, in connection with the upcoming two sites (1076 and 1077) in the Lower Congo Basin, will allow us to reconstruct the changing influence of Congo River, coastal upwelling, and openocean contributions to the dynamics of the region. Three holes were cored with the advanced hydraulic piston corer (APC) at Site 1075 to a maximum depth of 207.2 meters below seafloor (mbsf), which recovered an apparently continuous interval of Pleistocene to upper Pliocene age. Hole 1075A was cored with the APC to 201.5 mbsf. Twenty-two cores were taken at Hole 1075B with the APC to a depth of 204.5 mbsf, and Hole 1075C was cored to 207.2 mbsf. Sediments from Site 1075 consist of one lithostratigraphic unit composed entirely of greenish gray diatomaceous clay and nannofossil-bearing diatomaceous clay. The sediment is bioturbated and shows a gradual increase in lithification with depth but no structural or lithologic change. The sediments have overall low calcium carbonate contents of generally <2.5 wt%. Biogenic portions of the sediment contain abundant diatoms with variable amounts of nannofossils, rare silicoflagellates, siliceous sponge spicules, phytoliths, and traces of radiolarian and foraminiferal fragments. Sedimentation rates for the recovered sequence average 100 m/m.y. Detailed comparisons between the magnetic susceptibility record generated on the multisensor track (MST) and high-resolution color reflectance measured with the Minolta spectrophotometer demonstrated complete re-