Miracle-dz/UniFAR-FTUs huggingface dataset:
Perioperative chemotherapy of oxaliplatin combined with S-1 (SOX) versus postoperative chemotherapy of SOX or oxaliplatin with capecitabine (XELOX) in locally advanced gastric adenocarcinoma with D2 gastrectomy: A randomized phase III trial (RESOLVE trial)

Abstract Background Surgery alone is not sufficient to achieve satisfactory prognosis for locally advanced gastric cancer (LAGC), and perioperative therapies have been proposed to improve survival outcome. However, the optimal modality and regimen of perioperative chemotherapy are yet to be identified. This study compared the efficacy and safety of SOX as perioperative chemotherapy versus SOX or XELOX as postoperative chemotherapy after D2 gastrectomy in patients with LAGC. Methods The RESOLVE Trial is a three-arm, randomized, multicenter, open-label phase III trial. Patients with stage cT4a/N+M0 or cT4bNxM0 gastric or gastro-esophageal junction adenocarcinoma were enrolled. All patients received standard gastrectomy with D2 lymphadenectomy. Arms A and B respectively received 8 cycles of adjuvant XELOX (capecitabine 1000 mg/m2, bid, d1-14, oxaliplatin 130 mg/m2, d1, q3W) or SOX (TS-1: 40-60 mg bid, d1-14, oxaliplatin: 130 mg/m2 d1, q3W). Arm C received 3 cycles of neoadjuvant SOX and 5 cycles of adjuvant SOX followed by 3 cycles of TS-1. The primary endpoint was 3-year disease-free survival rate (3yDFS%) in the mITT population. Results A total of 1094 patients were randomized between 08/2012 and 02/2017, 364/365/365 in arm A/B/C, and 454 recurrences/deaths were observed by 07/2019. Baseline characteristics were similar between arms (overall, male 75.2%; median age 60.0 years; GEJ 36.5%). Peri-operative SOX improved 3yDFS% compared with post-operative XELOX (3yDFS%, 62.0% in Arm C, 54.8% in Arm A; HR 0.79, 95%CI [0.62-0.99]; p = 0.045). Post-operative SOX was non-inferior to post-operative XELOX (3yDFS%, 60.3% in Arm B, 54.8% in Arm A; HR 0.85, 95%CI [0.67-1.07]; p = 0.162). Resection rate was 90.4% in Arm A, 92.7% in Arm B, and 85.5% in Arm C, respectively. Thirty-day mortality rate was all 0.9% for Arms A, B and C. Conclusions Perioperative SOX is superior to post-operative XELOX while post-operative SOX is non-inferior to post-operative XELOX for LAGC after D2 gastrectomy. It provides the evidence of perioperative SOX in LAGC. Clinical trial identification NCT01534546. Legal entity responsible for the study The authors. Funding Taiho Pharmaceutical Co., Ltd. Disclosure All authors have declared no conflicts of interest.
Development of a Saudi food frequency questionnaire to evaluate the risk of CVD and T2DM in Saudi and British nutritionists and investigating its reliability and effectiveness

Globally, non-communicable diseases (NCDs) such as cardiovascular disease (CVD), type two diabetes mellitus (T2DM) and chronic respiratory disease are a leading cause of death. These diseases result in the death of around 2.8 million people each year, worldwide (WHO, 2012a). Western dietary habits and food supplies have resulted in the increased consumption of foods which are unhealthy. The consumption of unhealthy foods which are high in salt, saturated fats, low in fibres and vitamins have a major impact on the health of a person, which then increases the risk of various NCDs diseases such as CVD and T2DM. In terms of the Saudi Arabian population, this trend has caused an increase in the number of Saudi people who are now overweight and obese. Also, not enough dietary surveys have been carried out in KSA and thus the data available is not sufficient to explore the eating habits of the Saudi population. This research aims to develop and validate a culture-specific FFQ for dietary habits of the Saudi people to examine the risk factors associated with T2DM and CVD. Nutritionists were targeted as the sample group because they might have better eating habits than the public (Washi, 2000). In addition, general public members were also targeted to better understand the eating habits of a majority of Saudi people. Participants from both groups in the UK were also solicited. The study aimed to establish a baseline of self-reported behaviour for the sample group in KSA which can be followed in the future. Data was also collected on other related issues such as BMI and physical activity levels. The study achieved an estimated 47.7% response rate with the use of social media to acquire data. The study established a valid, reliable FFQ for the Saudi population, which allows for collecting sufficient data on the risk factors related to CVD and T2DM. The FFQ proved as a good tool in establishing a baseline for Saudi nutritionists and public for future cohort measurements. Comparing the results of the FFQs for screening the risk factors of CVD and T2DM in Saudi population showed an interesting trend. The analysis showed that there is a greater ratio of population who are smokers, overweight, obese and inactive in Saudi Arabia as compared to the British living in the UK. Hence, the implementation of important policies and intervention programmes is highly recommended in KSA. Awareness schemes to increase the community’s knowledge about CVD and T2DM risk factors is necessary to encourage nutritionists and specifically young adults in KSA to adopt healthy balanced diets while promoting physical activity and avoiding harmful activities.
Dermatology Life Quality Index in Patients Infected with HIV: A Comparative Study

Background HIV-infected patients with skin diseases have impaired dermatology quality of life due to severe and refractory nature of dermatoses occurring in them but literature on this aspect is sparse. Aims To assess the dermatology life quality index (DLQI) in HIV-infected patients with skin diseases and to assess the effect of antiretroviral therapy (ART) on DLQI.
Gestational diabetes : long-term, metabolic consequences for the mother and child

Gestational diabetes (GDM) indicates increased risk for diabetes and the metabolic syndrome in women. Research on prenatal exposure to GDM as a risk factor for metabolic diseases is conflicting. Overweight (body mass index ≥ 25 kg/m2) is a strong risk factor for GDM and metabolic diseases; however, there are few published previous studies distinguishing the separate effects of overweight and GDM on the later risk for metabolic diseases in women and their children. The present study evaluated pre-pregnancy overweight and GDM as determinants of long-term risk for diabetes and hypertension in women, and the metabolic consequences of prenatal exposures to maternal pre-pregnancy overweight and different types of maternal diabetes in children. The results are based on prospective, clinical data from Oulu University Hospital (n = 63 mothers and their children), and the Northern Finland Birth Cohort 1986 (NFBC 1986, n = 9,362 mothers and their 9,479 children). Compared to normal-weight mothers with normal glucose tolerance in pregnancy, the NFBC 1986 mothers with simultaneous pre-pregnancy overweight and GDM had strikingly high risks for developing diabetes (hazard ratio, HR 47.2; 95% confidence interval 25.5–87.4) and hypertension (HR 9.2 [6.1–13.9]) twenty years after delivery. The risks for these diseases were elevated in mothers with pre-pregnancy overweight even when they had normal glucose tolerance during pregnancy (HR diabetes 12.6 [7.4–21.6], HR hypertension 2.9 [2.1–3.9]). GDM per se indicated increased risk only for diabetes (HR 10.6 [4.2–27.0]). In the cohort from Oulu University Hospital, increased fasting insulin concentration (P = 0.04), first phase insulin response (P = 0.03), and homeostasis model value for insulin secretion (P = 0.008) were already observed at pre-school age in the offspring of mothers with Type 1 diabetes compared with offspring of mothers with GDM. In the NFBC 1986 offspring, the prevalence of metabolic syndrome was 2.4% at age 16 years, using the International Diabetes Federation pediatric definition. Abdominal obesity, a waist girth over half one’s length, defined approximately 85% of the adolescents with metabolic syndrome. The risks for overweight and abdominal obesity were high in those with prenatal exposure to both maternal pre-pregnancy overweight and GDM (odds ratio for overweight 4.1 [1.9–8.6], for abdominal obesity 3.8 [1.7–8.8]). In children of normal-weight women, prenatal exposure to GDM was not associated with increased risk of these outcomes. Based on this study, preventing and reducing overweight in fertile age seems to be a key target for preventing metabolic diseases in women and their children.
Study of Lenalidomide Plus Dexamethasone Versus Dexamethasone Alone in Relapsed or Refractory Multiple Myeloma (MM): Results of a Phase 3 Study (MM-010).

High-dose dexamethasone (Dex) remains a standard therapy for relapsed or refractory MM. Lenalidomide is a novel, orally administered, immunomodulatory drug (IMiD) that has single-agent activity against MM and additive effects when combined with Dex. In this phase 3, multicenter, randomized, double-blind trial, 351 patients with relapsed or refractory MM were enrolled from clinical centers in Europe, Israel, and Australia. Patients were treated with Dex 40 mg daily on days 1–4, 9–12, and 17–20 every 28 days and were randomized to receive either lenalidomide 25 mg daily orally on days 1–21 every 28 days or placebo. Beginning at cycle 5, the dose intensity of Dex was reduced to 40 mg daily on days 1–4 only every 28 days. Patients resistant to Dex were excluded. Patients were stratified with respect to B2M (≤ 2.5 vs. > 2.5 mg/mL), prior stem cell transplant (none vs. ≥1), and number of prior regimens (1 vs > 1). A pre-planned interim analysis of time to progression (TTP; primary endpoint), response (Blade criteria), and safety data was performed by an independent Data Monitoring Committee (IDMC) when at least half the number of disease progressions required for full statistical power had occurred (50% information). The treatment arms were well balanced for prognostic features. With a study duration of 18 months, the median TTP for patients treated with the combination of lenalidomide plus Dex was 13.3 months compared to 5.1 months for patients treated with Dex and placebo (p < 0.000001). The overall response rate was greater in patients who received lenalidomide plus Dex than in patients who were given Dex alone (58% vs. 22%; p < 0.001). Grade 3 or 4 neutropenia adverse events were reported more frequently in patients given combination therapy than in patients treated Dex alone (16.5% vs. 1.2%), however grade 3 or 4 infections were reported with similar frequencies between treatment groups. Thromboembolic events occurred in 8.5% of patients in the lenalidomide/Dex group and in 4.5% of patients in the Dex alone group. Otherwise, the safety profile of lenalidomide/Dex was similar to that of Dex alone. Conclusion: Combination lenalidomide/Dex is a relatively well-tolerated and active oral regimen for patients with relapsed or refractory MM. The difference in TTP between the 2 arms surpassed the pre-specified O’Brien-Fleming boundary for superior efficacy (p < 0.0015) and the IDMC recommended the data be released to all study participants. Prophylactic antithrombotic therapy should be considered for patients undergoing treatment with lenalidomide/Dex. These data support further evaluation of this combination in previously untreated patients with MM.
Psychometric Evaluation Of Appetite Questionnaires In Elderly Polish Patients With Heart Failure Patient Preference and Adherence

Purpose: Loss of appetite is caused by multifaceted disorders and affects an average of 40% of patients with heart failure (HF). The Council on Nutrition Appetite Questionnaire (CNAQ) and the Simpli ﬁ ed Nutritional Appetite Questionnaire (SNAQ) are designed to assess appetite among older adults. We aimed to assess the psychometric properties of both CNAQ and SNAQ questionnaires in elderly Polish patients with HF. Methods: The study sample involved 103 patients aged ≥ 65 years with HF diagnosed according to the New York Heart Association (NYHA) functional classes II – IV. The study was conducted among hospitalized patients with HF. In the study, the Mini Nutritional Assessment (MNA) questionnaire was used to assess the validity of the questionnaire. The evaluation of the following psychometric values was taken into account: data quality and homogeneity, factor structure, construct validity and internal consistency. Results: Parallel analysis con ﬁ rmed the unidimensional structure of both CNAQ and SNAQ. The adjusted eigenvalues for CNAQ were 3.50 for the ﬁ rst factor and 0.62 for the second factor, and for SNAQ they were 2.2 and 0.31, respectively. For CNAQ, the desired CFA values were obtained after modi ﬁ cation (RMSEA <0.06, CFI, TLI> 0.95), for SNAQ without modi ﬁ cation (RMSEA <0.06, CFI, TLI> 0.95). The correlation between CNAQ and SNAQ and MNA was strong (rs = 0.8 and rs = 0.81, p <0.001, respectively). The internal consistency of the CNAQ and SNAQ tools was 0.88 and 0.86, respectively. Conclusion: The CNAQ and SNAQ questionnaires have positive psychometric properties and can be used to evaluate appetite among elderly Polish patients with HF.
Machine learning-based prediction of response to PARP inhibition across cancer types

PARP inhibitors (PARPi) are FDA approved for the treatment of BRCA1/2 deficient breast and ovarian cancer, but a growing body of pre-clinical evidence suggests the drug class holds therapeutic potential in other cancer types, independent of BRCA1/2 status. Large-scale pharmacogenomic datasets offer the opportunity to develop predictors of response to PARPi’s in many cancer types, expanding their potential clinical applicability. Response to the PARPi olaparib was used to identify a multi-gene PARPi response signature in a large in vitro dataset including multiple cancer types, such as breast, ovarian, pancreatic, lung cancer, osteosarcoma and Ewing sarcoma, using machine learning approaches. The signature was validated on multiple independent in vitro datasets, also testing for response to another PARPi, rucaparib, as well as two clinical datasets using the cisplatin response as a surrogate for PARPi response. Finally, integrative pharmacogenomic analysis was performed to identify drugs which may be effective in PARPi resistant tumors. A PARPi response signature was defined as the 50 most differentially transcribed genes between PARPi resistant and sensitive cell lines from several different cancer types. Cross validated predictors generated with LASSO logistic regression using the PARPi signature genes accurately predicted PARPi response in a training set of olaparib treated cell lines (80-89%), an independent olaparib treated in vitro dataset (66-77%), and an independent rucaparib treated in vitro dataset (80-87%). The PARPi signature also significantly predicted in vitro breast cancer response to olaparib in another separate experimental dataset. The signature also predicted clinical response to cisplatin and survival in human ovarian cancer and osteosarcoma datasets. Robust transcriptional differences between PARPi sensitive and resistant tumors accurately predict PARPi response in vitro and cisplatin response in vivo for multiple tumor types with or without known BRCA1/2 deficiency. These signatures may prove useful for predicting response in patients treated with PARP inhibitors.
Receptive Methods in Music Therapy: Techniques and Clinical Applications for Music Therapy Clinicians, Educators, and Students [Book Review]

Review(s) of: Receptive Methods in Music Therapy: Techniques and Clinical Applications for Music Therapy Clinicians, Educators, and Students, by Grocke, D. , and Wigram, T. (2007), London: Jessica Kingsley Publishers. AUS$53.95, 270 pages, ISBN: 978-184310-413-X.
Investigating Whether Consuming Meals in a Dining Room Impacts Patients’ Mood, Level of Interaction, and Subsequent Nutrient Intake in a Stroke Rehabilitation Ward.

Background/objectives: Malnutrition is evident in hospitals and stroke patients are at increased risk. Protected mealtimes may help increase nutrient intake especially when patients interact and enjoy the dining room atmosphere. The aim of this research is to investigate if eating in a communal dining room increases nutritional intake compared to eating at the bedside and to investigate whether patient interaction and mood affects patient nutrient intake. Population/methods: A randomised cross-sectional study of 20 patients, assessing a comparison of patient’s mealtime consumption at lunchtime in the dining room and at the beside. Patients’ meals were weighed before and after consumption as well as an estimated percentage of their meals consumed. Patients’ interaction was observed and noted using a modified case report form. The Hammond depression scale was used to score patients’ mood. Patient and staff satisfaction surveys were completed at the end of the study period. Results: There was no significant difference in protein and energy consumption in the dining room (16.4g protein and 379.2kcal) compared to at the bedside (13.2g protein and 333.8kcal), p=0.160 and p=0.110 respectively. Interaction was higher in the dining room. The percentage mealtime consumption increased the more interactive a patient was from a mean of 74% in less interactive patients to 98% in highly interactive patients (p=0.193). There was no significant association between depression score and mealtime consumption. All 19 patients enjoyed eating in the dining room and 14 out of the 19 patients preferred eating in the dining room. Conclusion: Further studies are required to explore how intake can be improved among stroke rehabilitation patients.
Does fixation of fibular fractures accompanying distal tibial fractures affect the ankle stability?

The aim of the surgical fixation of combined distal tibial fibular fracturesis to achieve good alignment and early mobilization of the patient (1). Various types of osteosyntheses are available for the sefractures. The fixation methods included open reduction– internal fixation, external fixation, close dreduction–intramedullary nailing, andminimally invasive plating systems (2, 3). Every method has its own advantages and disadvantages, with no consensus for the best fixation method (2-4).
Research foci for Career and Technical Education: Findings from a national Delphi study

Research Foci for Career and Technical Education: Findings from a National Delphi Study. (August 2008) Jeanea Marie Lambeth, B.S.; M.A., The University of Arizona Co-Chairs of Advisory Committee: Dr. Theresa Pesl Murphrey Dr. Matt Baker Identifying a research agenda and critical research activities is crucial for continuous development of Career and Technical Education (CTE) programs that meet the needs of students, industry, and society. Previous studies have expressed a need for relevant and focused research for the CTE profession. The primary purpose of this study was to identify consensus among CTE experts using a Delphi technique regarding problems, objectives, and activities that serve as a research agenda for CTE. The study panel was composed of experts from 25 states in the United States and represented 57 affiliations and organizations with direct ties to CTE. The Delphi process for this study was conducted in three rounds. Data were collected using the online survey collector, Survey MonkeyTM. The qualitative data were analyzed using the Affinity Diagram method of data analysis. At the conclusion of the data analysis from the Delphi rounds, the basic structure for the National CTE Research Agenda was developed. Rounds Four and Five served as validation rounds for the findings from the Delphi process. Data collection methods included online instruments using an internet-based survey tool. Data analysis revealed five research problem areas, 15 research objectives
IT Competencies And The Conditions For Training Effectiveness : A Study On Malaysian University Clerical Workers

This thesis investigates the levels of IT competencies and the conditions for training effectiveness among Malaysian university clerical workers using both quantitative and qualitative research methods. Seven conditions that affect the transfer of IT training to the workplace according to the order of importance were identified based on an Expert of Opinion Analysis: organisational management, trainee characteristics, IT facilities, trainer competency, training methodology, organisational system and work culture. These conditions or constructs were formulated into semistructured interview and survey questionnaire, which was answered by 21 interviewees and 554 respondents respectively. Qualitative data were transcribed and categorised to identify themes and patterns while quantitative data underwent traditional reliability and validity tests using Cronbach alpha and factor analyses. A major finding is that clerical workers acquire IT competence through informal training process particularly mentoring, self and experiential learning. However, informal training mode functions as a complement to formal training. A clerical worker normally acquires basic skills through formal training and will try to master advanced IT skills through informal training. Analysis of data indicated that most of the interviewees have high levels of competence in word processing, spreadsheet and communication and Internet. Findings from the Pearson correlation analysis is consistent with the Expert Opinion Assessment whereby the highest Pearson correlation value is for organisational management, while the lowest Pearson correlation value is for work culture. Differences of mean ranking for items measuring IT competence are attributed to age, work unit and academic qualification. Finally, all seven constructs are equally important but have varying impact on IT competence. Therefore, all seven constructs should be viewed in an integrated manner in accordance to the conceptual model proposed in this study.
Insights into healing response in severe sepsis from a connective tissue perspective : a longitudinal case-control study on wound healing, collagen synthesis and degradation, and matrix metalloproteinases in patients with severe sepsis

The study population consisted of 44 patients with severe sepsis and 15 healthy controls. Serum samples were obtained during ten days of severe sepsis and twice again, three months and six months later. Experimental suction blisters were performed twice during severe sepsis and at 3 and 6 months. Serum samples were obtained and suction blisters were induced once in controls. Biochemical analyses were performed to assess the level of procollagen I and III aminoterminal propeptides (PINP, PIIINP), reflecting the synthesis of corresponding collagens; in serum and suction blister fluid. In addition collagen I degradation product in serum was measured. Physiological measurements of transepidermal water loss and blood flow were done in order to evaluate the re-epithelisation rate and blood flow in an experimental wound. Levels of matrix metalloproteinases (MMPs) 2, 8 and 9 were measured from serum and suction blister fluid.