Miracle-dz/UniFAR-FTUs huggingface dataset:
Triggering receptor expressed on myeloid cells (TREM‐1) is regulated post‐transcriptionally and its ligand is present in the sera of some septic patients

Inflammation is necessary for survival, but it is also an important cause of human morbidity and mortality, as exemplified by sepsis. During inflammation, cells of the innate immune system are recruited and activated in response to infection, trauma or injury. These cells are activated through receptors, such as Toll‐like receptors (TLRs), which recognize microbial ligands such as lipopolysaccharide (LPS). Triggering receptor expressed on myeloid cells (TREM)‐1 amplifies the inflammatory response initiated by TLRs, and its expression on the surface of monocytes increases in the presence of TLR ligands. Here we have shown that in monocytes TREM‐1 mRNA levels, measured by reverse transcription–polymerase chain reaction (RT–PCR), remained unchanged and TREM‐1 protein levels, measured by flow cytometry, increased, indicating that LPS increases TREM‐1 expression by a post‐transcriptional mechanism. We also showed that TREM‐1/Fc fusion protein decreased the ability of the sera of some patients with sepsis to activate monocytes, indicating that the TREM‐1 ligand, whose identity is unknown, may be present in the sera of some of these patients. We describe a mechanism for the regulation of TREM‐1 expression on monocytes and the possible presence of its ligand in serum; these findings help to explain the contribution of TREM‐1 during systemic inflammation.
A 5 GHz wide-range CMOS active phase shifter for wireless beamforming applications

A CMOS 5.2 GHz active phase shifter is presented. Based on a tunable all-pass filter, this implementation achieves a wide phase-shift range with low loss, and minimizes the number of on-chip passive elements. Fabricated in a subset of a 0.25 /spl mu/m SiGe BiCMOS process, measurements of the active phase shifter show an insertion loss of 2 dB, an IIP3 of 1 dBm, and a phase shift range of 240/spl deg/. Power consumption of the core circuitry is 36.3 mW from a single 2.5 V power supply.
Metabolic Syndrome in Children and Adolescents Living with HIV

Background: Metabolic syndrome (MetS) is considered an independent risk factor for developing cardiovascular disease. It is well known that the prevalence of metabolic disorders have increased in pediatric HIV-infected children. The objective of this study is to assess the prevalence and characteristics of MetS in HIV-infected children and adolescents in Spain. Methods: A cross-sectional multicenter study in 152 patients from the pediatric cohort of the Spanish AIDS Research Network (CoRISpe) was performed. MetS was defined according to the new International Diabetes Federation (IDF) diagnostic criteria and the modified National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) criteria. Measurements included anthropometry, waist circumference, blood pressure, fasting lipids, glucose and insulin and lipodystrophy assessment. Demographic, clinical, immunological, virological and antiretroviral therapy data were obtained from the Network database. Results: An abnormally low high-density lipoprotein-cholesterol level was the most prevalent disturbance (21.05%) found. Three patients met IDF criteria for MetS (1.97%), and MetS was significantly associated with lipohypertrophy (P=0.029) in the analysis. When the modified NCEP-ATP III criteria were used, the prevalence of MetS was 5.92% (9 patients), and MetS was significantly associated with Tanner stage ≥2 (P=0.041), lipohypertrophy (P=0.001) and higher Z scores for weight and body mass index (P=0.002 and P<0.001). Insulin resistance was observed in 17 patients (11.18%) and was associated with MetS (as per the modified NCEP-ATP III criteria) (P=0.03) and lower high-density lipoprotein-cholesterol values (P=0.036). Conclusions: The prevalence of MetS in our cohort was 1.97% or 5.92%, depending on the diagnostic criteria used. MetS should be actively assessed, particularly in children who show lipohypertrophy.
Section 3: -Cell Function and Turnover: Genetic and Metabolic Factors Early Development of -Cells Is Impaired in the GK Rat Model of Type 2 Diabetes

The Goto-Kakisaki (GK) rat is a genetic model of type 2 diabetes obtained by selective inbreeding of mildly glucose-intolerant Wistar rats. Previous studies have shown that at birth, the � -cell mass of the GK rat is severely reduced compared with that of the Wistar rat. Therefore, � -cell deficit could be the primary defect leading to type 2 diabetes in this model. To identify the abnormality at the origin of the � -cell mass deficit, we compared the fetal development of GK and Wistar rats. Our study reveals that during early development (embryonic day 12‐14 [E12‐14]), GK fetuses present a delayed global growth that progressively recovers: at birth, no size or weight difference persists. However, from E18 onward, the weight and DNA content of the pancreas and liver are reduced by 30% in the GK fetuses. Cell proliferation is reduced in the GK pancreas from E16 to E20. Whereas apoptotic cells are scarce in the Wistar fetal pancreas, a wave of apoptosis from E16 to E18 was detected in the GK pancreas. Analysis of pancreas differentiation revealed that from E12 to E14, there are no significant differences in the number of � - and � -cells between the GK and Wistar pancreas. However, by E16, the average number of � -cells in the GK pancreas represents only 50% that of the Wistar pancreas, and this difference persists until birth. The number of � -cells was reduced by 25% from E18 to E21. To determine whether the defect in GK pancreas development depends on intrinsic pancreatic factors or on endocrine extrapancreatic factors, we performed in vitro cultures of E12 pancreatic rudiments. The cultures show that in vitro, the growth and endocrine differentiation of the GK and Wistar pancreatic rudiments are identical. Thus, impaired development of the GK
RESEARCH AND DEVELOPMENT OF DSP-BASED FACE RECOGNITION SYSTEM FOR ROBOTIC REHABILITATION NURSINGBEDS

This article describes the development of DSP as the core of the face recognition system, on the basis of understanding the background, significance and current research situation at home and abroad of face recognition issue, having a in-depth study to face detection, Image preprocessing, feature extraction face facial structure, facial expression feature extraction, classification and other issues during face recognition, and have achieved research and development of DSP-based face recognition system for robotic rehabilitation nursing beds. The system uses a fixed-point DSP TMS320DM642 as a central processing unit, with a strong processing performance, high flexibility and programmability.
Low Loss, Compact TM-Pass Polarizer Based on Hybrid Plasmonic Grating

A low-loss, compact TM-pass polarizer is demonstrated based on hybrid plasmonic grating on silicon-on-insulator platform. Since the large mode distribution mismatch and plasmonic effect significantly influence the transmission and reflection spectrum of the device, the traditional theory of Bragg grating cannot fully explain this phenomenon. Here, we proposed an analysis method which takes effective index and mode overlap together into consideration to design this polarizer. A compact length of $2.5~\mu \text{m}$ with extinction ratio over 25 dB is realized simultaneously. Moreover, the insertion loss is only 0.088 dB, which is comparable to dielectric-based devices.
A comparison between amount of television viewing time and attentional abilities

The purpose of this study was to investigate the relationship between television viewing time and auditory attention with the effects of development examined. The study used 64 females and 29 males who were in regular and special education classes (i.e., 24 third graders, 32 fourth graders and 37 fifth graders). The researcher constructed two instruments to obtain data about TV viewing time. The Stanford Achievement Test Ninth Edition (SAT9) Listening Subtest raw score was used as a measure of attention, while the SAT9 Total Basic Skills (TBS) raw score was used as a measure of overall achievement. Data about TV viewing time was gathered during a class period. No gender differences were found on any variable so data were combined. Significant relationships were found between Grade 4 and SAT9 scores (r=.29, p<.005) and Grade 5 and SAT9 scores (r=-.30, p<.005). An Analysis of Variance (ANOVA) was performed. A significant difference between the three grade levels in scores on the SAT9 (F=5.52, p<.005) resulted. Tukey’s post hoc analysis resulted in a significant difference between Grade 4 (M=30.00) and Grade 5 (M=25.81), which suggested a curvilinear relationship. A significant relationship between the SAT9 Listening Subtest Scores and the TBS Scores (r=.50, p<.001) was found. The results of the study provide additional evidence that no relationship exists between the amount of television viewing and attentional abilities. Future studies should a) consider developmental level, gender, socioeconomic status, ethnicity and intelligence; b) control for confounding variables; c) employ a longitudinal design; and d) use interval scale for assigning TV viewing time.
Replication strategy of human hepatitis B virus

To study the replication strategy of the human hepatitis B virus, the 5' end of the RNA pregenome and the initiation sites of DNA plus and minus strands have been mapped. The RNA pregenome was found to be terminally redundant by 120 nucleotides; it is initiated within the pre-C region and may also function as mRNA for synthesis of the major core protein and the hepatitis B virus reverse transcriptase. The hepatitis B virus DNA minus strand is initiated within the direct repeat sequence DR1, it contains a terminal redundancy of up to eight nucleotides, and its synthesis does not require any template switch. The DNA plus strand is primed by a short oligoribonucleotide probably derived from the 5' end of the RNA pregenome, and its synthesis is initiated close to the direct repeat sequence DR2. For its elongation to pass the discontinuity in the DNA minus strand an intramolecular template switch occurs using the terminal redundancy of this template. Thus, the route of reverse transcription and DNA replication of hepatitis B viruses is fundamentally different from that of retroviruses.
Growth of Pseudomonas aeruginosa mutants lacking glutamate synthase activity

Mutant strains SU1, SU4, and US1 lacking glutamate synthase (GOGAT) activity were isolated from strains of P. aeruginosa for which histidine is a growth rate-limiting source of nitrogen. Strains SU1 and SU4 were unable to grow when a low concentration of ammonia and a variety of compounds, including histidine, were supplied as sole sources of nitrogen. A revertant of strain SU1, strain 39, produced no GOGAT but high levels of nicotinamide adenine dinucleotide-dependent glutamate dehydrogenase and had restored ability to grow on a limited number of nitrogen sources. Strain US1 grew at the same rate in histidine medium as did its parent; it was derepressed for glutamine synthase synthesis, and histidase was less sensitive to repression by ammonia than in the parent strain. We conclude that GOGAT is not essential for growth on histidine but high levels of glutamine synthase are required nd high levels of nicotinamide adenine dinucleotide-dependent glutamate dehydrogenase can sustain growth at low concentrations of ammonia in the absence of GOGAT.
Efficacy and safety of cryoballoon ablation versus radiofrequency catheter ablation in atrial fibrillation: an updated meta-analysis

Introduction Cryoballoon ablation (CBA) and irrigated radiofrequency catheter ablation (RFCA) are the main treatments for drug-refractory symptomatic atrial fibrillation (AF). Aim To compare the efficacy and safety between CBA and RFCA for the treatment of AF. Material and methods We searched the Embase and Medline databases for clinical studies published up to December 2016. Studies that satisfied our predefined inclusion criteria were included. Results After searching through the literature in the two major databases, 20 studies with a total of 9,141 patients were included in our study. The CBA had a significantly shorter procedure time (weighted mean difference (WMD) –30.38 min; 95% CI: –46.43 to –14.33, p = 0.0002) and non-significantly shorter fluoroscopy time (WMD –3.18 min; 95% CI: –6.43 to 0.07, p = 0.06) compared with RFCA. There was no difference in freedom from AF between CBA and RFCA (CBA 78.55% vs. RFCA 83.13%, OR = 1.15, 95% CI: 0.95–1.39, p = 0.14). The CBA was associated with a high risk of procedure-related complications (CBA 9.02% vs. RFCA 6.56%, OR = 1.56, 95% CI: 1.05–2.31, p = 0.03), especially phrenic nerve paralysis (PNP, OR = 10.72, 95% CI: 5.59–20.55, p < 0.00001). The risk of pericardial effusions/cardiac tamponade was low in the CBA group (CBA 1.05% vs. RFCA 1.86%, OR = 0.62, 95% CI: 0.41–0.93, p = 0.02). Conclusions For AF, CBA was as effective as RFCA. However, CBA had a shorter procedure time and a non-significantly shorter fluoroscopy time, a significantly high risk of PNP and a low incidence of pericardial effusions/cardiac tamponade compared with RFCA.
Bag-of-Features based Activity Classification using Body-joints Data

In this paper, we propose a Bag-of-Joint-Features model for the classification of human actions from bodyjoints data acquired using depth sensors such as Microsoft Kinect. Our method uses novel scale and translation invariant features in spherical coordinate system extracted from the joints. These features also capture the subtle movements of joints relative to the depth axis. The proposed Bag-of-Joint-Features model uses the well known bag-of-words model in the context of joints for the representation of an action sample. We also propose to augment the Bag-of-Joint-Features model with a Hierarchical Temporal histogram model to take into account the temporal information of the body-joints sequence. Experimental study shows that the augmentation improves the classification accuracy. We test our approach on the MSR-Action3D and Cornell activity datasets using support vector machine.
Network Traffic Classification using Machine Learning Techniques over Software Defined Networks

Nowadays Internet does not provide an exchange of information between applications and networks, which may results in poor application performance. Concepts such as application-aware networking or network-aware application programming try to overcome these limitations. The introduction of Software-Defined Networking (SDN) opens a path towards the realization of an enhanced interaction between networks and applications. SDN is an innovative and programmable networking architecture, representing the direction of the future network evolution. Accurate traffic classification over SDN is of fundamental importance to numerous other network activities, from security monitoring to accounting, and from Quality of Service (QoS) to providing operators with useful forecasts for long-term provisioning. In this paper, four variants of Neural Network estimator are used to categorize traffic by application. The proposed method is evaluated in the four scenarios: feedforward; Multilayer Perceptron (MLP); NARX (Levenberg-Marquardt) and NARX (Naive Bayes). These scenarios respectively provide accuracy of 95.6%, 97%, 97% and 97.6%.
Quadrupole moments and hyperfine constants of metastable states of Ca{sup +}, Sr{sup +}, Ba{sup +}, Yb{sup +}, Hg{sup +}, and Au

Atomic quadrupole moments and hyperfine constants of the metastable {sup 2}D{sub 3/2,5/2} states of Ca{sup +}, Sr{sup +}, Ba{sup +}, Yb{sup +}, and Hg{sup +} are calculated by the multiconfiguration Dirac-Hartree-Fock and relativistic configuration-interaction methods. For Hg{sup +}, the configuration is 5d{sup 9}6s{sup 2}. For the other ions, the configuration consists of a single d-electron outside a set of closed shells. Current interest in the quadrupole moments of these states is due to the fact that optical transitions of these ions may be useful as references for frequency standards. Energy shifts of the metastable states due to the interactions of the quadrupole moments with external electric field gradients are among the largest sources of error in these frequency standards. For the quadrupole moments, agreement is obtained to within about 10% with the available measurements. For the hyperfine constants, good agreement is obtained with measurements and with other calculations, except for the A factors of the {sup 2}D{sub 5/2} states of Sr{sup +}, Ba{sup +}, and Yb{sup +}, where the correlation effects are so large that they reverse the sign of the constant relative to the Dirac-Hartree-Fock value. As a test of the Hg{sup +} calculational methods, quadrupole moments and hyperfinemore » constants are calculated for the 5d{sup 9}6s{sup 2} {sup 2}D{sub 3/2,5/2} states in isoelectronic neutral Au. This yields a value of the nuclear quadrupole moment Q({sup 197}Au)=+0.587(29) b. « less
Multiview ToF sensor fusion technique for high-quality depth map

The Time-of-Flight (ToF) sensor has been widely used in computer vision fields since it can provide depth information in real time. However, the depth map obtained from ToF sensor is distressed with error, and has a lower resolution than general cameras. In this paper, we propose a novel framework to fuse and upsample multi-view depth maps obtained from multiple ToF sensors. The proposed method can be robust to the camera calibration error and effectively applied to the Multi-view Video plus Depth (MVD) system. For that, we perform depth balancing and confidence map based multi-view depth fusion. The depth balancing adjusts the distribution of depth values between multiple ToF sensors. It can provide a coherent depth for the corresponding points between depth maps. Confidence map based multi-view depth fusion technique can restore the depth acquisition error and align multiple depth maps well with the corresponding color image by using only reliable depth values. Experimental results show that the proposed method using multiple ToF sensors is superior to the conventional method based on the 2D-plus-depth system consisting of one color camera and one depth sensor.
Factor VIII and IX Variants. Relationship between Haemophilia BM and Haemophilia B+

Abstract. Haemophilia A and B can be divided into at least two groups which are different from the moderate and severe forms already known. Most patients have a true deficiency, lacking both coagulant and antigenic activities, while 10% of them display a reduced coagulant activity with antigenic determinants in common with normal factor VIII or IX. These factor VIII or IX variants are genetically determined but speculation about the exact mode of inheritance would be premature.
Irradiation of the pituitary in the treatment of malignant exophthalmos.

PROGRESSIVE protrusion of the eyes may occur in the presence of severe or mild thyrotoxicosis, after successful treatment of this toxic state, or in patients exhibiting no evidence of thyroid disease. This progressive exophthalmos may be spontaneously or artificially interrupted before any other eye signs or symptoms develop. If further progression of the exophthalmos occurs, however, certain accessory signs and symptoms may appear which characterize the clinical picture of “malignant exophthalmos. ” These features have been described by Mulvaney (1) and others (2–4). The initial symptoms are usually orbital, retro-orbital, or frontal pain; burning; lacrimation; photobia; and, less commonly, diplopia. The eyes become obviously proptosed. The lids swell. Edema fluid appears under both bulbar and palpebral conjunctivae. These conjunctival sacs may protrude between the lids in transverse bands or hang down over the cheeks for a distance of several centimeters. The palpebral aperture may increase in size. When.
NASCAP/GEO charging analysis of INSAT-4B

NASCAP/GEO code has been employed for the on-orbit charging analysis of INSAT-4B. Surface charging of the spacecraft under sunlit and eclipse conditions have been investigated. The INSAT-4B spacecraft is modelled by specifying geometry and the surface materials. The worst case and normal-case GEO plasma environments have been simulated for estimating the potential build up. The analysis has been carried out and extended for to the area of ungrounded ITOC islands on the multilayer insulation that covers the spacecraft body.
Prognostic factors for the long-term development of ocular lesions in 327 children with congenital toxoplasmosis

The aim of this study was to identify the high-risk factors associated with the development of ocular lesions in a large cohort of children with congenital toxoplasmosis (CT), irrespective of their gestational age at the time of maternal infection. Children were managed according to a standardized protocol and monitored for up to 14 years at the Croix-Rousse Hospital, Lyon, France. Cox model and a flexible regression, spline-based method were used for the analysis. During a median follow-up time of 6 years, 79 of the 327 children (24%) had at least one retinochoroidal lesion. No bilateral impairment of visual acuity was observed. The risk of a child developing ocular disease was higher not only when mothers were infected early during pregnancy, which was expected, but also when CT was diagnosed prior to or at the time of birth, when non-ocular manifestations were present at baseline and when birth was premature.
Mechanistic kinetic models of enzymatic cellulose hydrolysis—A review

Bioconversion of lignocellulose forms the basis for renewable, advanced biofuels, and bioproducts. Mechanisms of hydrolysis of cellulose by cellulases have been actively studied for nearly 70 years with significant gains in understanding of the cellulolytic enzymes. Yet, a full mechanistic understanding of the hydrolysis reaction has been elusive. We present a review to highlight new insights gained since the most recent comprehensive review of cellulose hydrolysis kinetic models by Bansal et al. (2009) Biotechnol Adv 27:833–848. Recent models have taken a two‐pronged approach to tackle the challenge of modeling the complex heterogeneous reaction—an enzyme‐centric modeling approach centered on the molecularity of the cellulase‐cellulose interactions to examine rate limiting elementary steps and a substrate‐centric modeling approach aimed at capturing the limiting property of the insoluble cellulose substrate. Collectively, modeling results suggest that at the molecular‐scale, how rapidly cellulases can bind productively (complexation) and release from cellulose (decomplexation) is limiting, while the overall hydrolysis rate is largely insensitive to the catalytic rate constant. The surface area of the insoluble substrate and the degrees of polymerization of the cellulose molecules in the reaction both limit initial hydrolysis rates only. Neither enzyme‐centric models nor substrate‐centric models can consistently capture hydrolysis time course at extended reaction times. Thus, questions of the true reaction limiting factors at extended reaction times and the role of complexation and decomplexation in rate limitation remain unresolved. Biotechnol. Bioeng. 2017;114: 1369–1385. © 2017 Wiley Periodicals, Inc.
Partial-Coupled Mode Space for quantum transport simulation in nanoscale double-gate MOSFETs

A novel computationally efficient approach for simulation of quantum transport in nanoscale devices is proposed. The idea is based on partial coupling between the modes of the nanoscale device. The proposed approach, termed Partial-Coupled Mode Space (PCMS), is applied to the double-gate MOSFETs and device targets from the ITRS roadmap were simulated. A Comparison with the fully Coupled-Mode Space (CMS) was carried out. The PCMS reduces more than 65 % of the computational burden while an accuracy of better than 0.1 % and 0.01 % is maintained in the device charge and terminal current respectively.