Miracle-dz/UniFAR-FTUs huggingface dataset:
Design, Synthesis, and Development of Pyrazolo[1,5-a]pyrimidine Derivatives as a Novel Series of Selective PI3Kδ Inhibitors: Part II—Benzimidazole Derivatives

Phosphoinositide 3-kinase (PI3K) is the family of lipid kinases participating in vital cellular processes such as cell proliferation, growth, migration, or cytokines production. Due to the high expression of these proteins in many human cells and their involvement in metabolism regulation, normal embryogenesis, or maintaining glucose homeostasis, the inhibition of PI3K (especially the first class which contains four subunits: α, β, γ, δ) is considered to be a promising therapeutic strategy for the treatment of inflammatory and autoimmune diseases such as systemic lupus erythematosus (SLE) or multiple sclerosis. In this work, we synthesized a library of benzimidazole derivatives of pyrazolo[1,5-a]pyrimidine representing a collection of new, potent, active, and selective inhibitors of PI3Kδ, displaying IC50 values ranging from 1.892 to 0.018 μM. Among all compounds obtained, CPL302415 (6) showed the highest activity (IC50 value of 18 nM for PI3Kδ), good selectivity (for PI3Kδ relative to other PI3K isoforms: PI3Kα/δ = 79; PI3Kβ/δ = 1415; PI3Kγ/δ = 939), and promising physicochemical properties. As a lead compound synthesized on a relatively large scale, this structure is considered a potential future candidate for clinical trials in SLE treatment.
Methods of statistical physics

1. Laws of thermodynamics 2. Thermodynamic relations 3. The ensemble theory 4. System Hamiltonians 5. The density matrix 6. The cluster variation method 7. Infinite series representations of correlation functions 8. The extended mean-field approximation 9. The exact Ising lattice identities 10. Propagation of short range order 11. Phase transition of the two-dimensional Ising model Appendix 1. The gamma function Appendix 2. The critical exponent in the tetrahedron approximation Appendix 3. Programming organization of the cluster variation method Appendix 4. A unitary transformation applied to the Hubbard Hamiltonian Appendix 5. Exact Ising identities on the diamond lattice References Subject index.
Effects Induced by the Passage of the Sun Through Dense Molecular Clouds

The problem of passages of the Solar System through dense, dusty and cold interstellar gas clouds is discussed. A considerable number of such encounters must have already occurred in the past and these events must have pushed the heliosphere inward to the region of the terrestrial planets, provided a number density of the cloud's material of the order of, or greater than, 1000 cm -3 , and relative velocities of about 20 km s -1 prevail. Under these conditions it will happen that the Earth is directly exposed to the interstellar flow. Neutral interstellar hydrogen and proton densities at the Earth's orbit are calculated under conditions of the heliosphere with the heliopause reduced to dimensions smaller than 1 AU. A simple two-fluids treatment of the incoming flow, ionized by the solar UV only, is proposed here and the amount of neutral interstellar hydrogen is assessed which is accreted by the Earth's atmosphere during one passage. The behavior of the flow variables is investigated by a 2D-hydrodynamic approach to model the interaction processes. Because of a reduction of the heliospheric dimension down to 1 AU, direct influence of the cloud's matter to the terrestrial environment and atmospheric chemistry must be envisaged. This will be briefly discussed in the paper.
Fast Rate-Distortion Optimization for Depth Maps in 3-D Video Coding

To ensure the fidelity of virtual views, rate-distortion optimization (RDO) criterion for the 3D extension of the High Efficiency Video Coding (3D-HEVC) is well designed, in which the synthesized view distortion (SVD) is introduced to derive the rate-distortion (RD) cost. To obtain accurate SVDs, the rendering operation is employed which demands a fairly high computational complexity. To address this problem, a fast RDO method for depth maps is proposed, which checks the RD cost during its calculation process. Specifically, given a coding mode, the RD cost is composed of several cumulative items. If the accumulated RD cost is equal to or exceeds the minimum RD cost of previously coded modes, it will not be necessary to continue the RD cost calculation for the mode. To reduce the encoding complexity, existing methods usually aim at reducing the number of tested modes or block partitions. To the best of our knowledge, it is the first time that the latent redundant complexity in the RD cost calculation is investigated and removed. Experimental results demonstrate that, compared with the 3D-HEVC reference software, the proposed method can save 28.1% of depth coding time with a small coding gain (0.04% BD-rate saving). An additional test is designed to evaluate four typical fast coding methods with/without the proposed method. Extensive results verify that the proposed method can be seamlessly combined with the state-of-the-art methods.
On-Chip Indoor-Outdoor Cold-Startup Circuit for Miniature Photovoltaic Cells

This work presents experimental results from an integrated low-power, low-area Dickson charge pump circuit, using 7.5 mm2 miniature photovoltaic cells, for cold-start operation. The proposed cold-start topology presents successful operation, both for indoor and outdoor lighting conditions, for input voltages as low as 440 mV. The cold-start circuit is implemented and fabricated in a 0.18 um CMOS process. The chip active area, occupied by the designed cold-start block, is 0.224 mm2. The area-efficient and low-power design of the presented cold-start circuit makes it ideal for micro-energy harvesting applications.
On-Farm Practices Associated with Multi-Drug-Resistant Escherichia coli and Vibrio parahaemolyticus Derived from Cultured Fish

Aquaculture activities have been implicated as responsible for the emergence of antimicrobial resistance (AMR), leading to broad dissemination and transference of antibiotic resistance to pathogens that affect humans and animals. The current study investigates the on-farm practices and environmental risk factors that can potentially drive the development and emergence of multi-drug-resistant (MDR) Escherichia coli and Vibrio parahaemolyticus in the aquaculture system. A cross-sectional study was conducted on 19 red hybrid tilapia (Oreochromis spp.) and 13 Asian seabass (Lates calcarifer, Bloch 1970) farms on the west coast of peninsular Malaysia. Data were collected using a structured questionnaire pertaining to farm demography, on-farm management practices and environmental characteristics. Multi-drug-resistant E. coli (n = 249) and V. parahaemolyticus (n = 162) isolates were analyzed using multi-level binary logistic regression to identify important drivers for the occurrence and proliferation of the MDR bacteria. On-farm practices such as manuring the pond (OR = 4.5; 95% CI = 1.21–16.57) were significantly associated with the occurrence of MDR E. coli, while earthen ponds (OR = 8.2; 95% CI = 1.47–45.2) and human activity adjacent to the farm (OR = 4.6; 95% CI = 0.75–27.98) were associated with an increased likelihood of MDR V. parahaemolyticus. Considering the paucity of information on the drivers of AMR in the aquaculture production in this region, these findings indicate the targeted interventions implementable at aquaculture farms to efficiently abate the risk of MDR amongst bacteria that affect fish that are of public health importance.
UNIVERSITY BRANDING AND STUDENT SATISFACTION: THE EMERGING LANDSCAPE OF UNIVERSITIES IN PAKISTAN

It gives higher education a competitive landscape brand-building for an educational institution. Adopting strategies that give them a viable advantage in the educational institute is fundamental for the universities. This study aims to understand how a university's reputation is shaped by its heritage, trustworthiness and service quality. It also investigates their relationship with students' satisfaction by using signaling theory. It also examines the impact of the university's reputation as a mediator. The data is collected from different university students in Pakistan through a questionnaire and then analyzed their results on Smart PL. Findings indicate an essential role of the university's brand image in students' minds, directly affecting the satisfaction level of students across Pakistan. Findings also indicate that university reputation plays a partial mediating role between the university's brand image Implications of findings for theory and practices were discussed in the study.
Successful Neuromuscular Blockade Reversal Using Sugammadex and Neostigmine Failed to Prevent Myasthenic Crisis After Emergency Surgery: A Case Report

Recent literature suggests that the use of sugammadex for the reversal of neuromuscular blocking agents (NMBAs) reduces the risk of postoperative myasthenic crisis (MC) in patients with myasthenia gravis (MG), particularly after thymectomy, but studies are lacking on emergency surgeries. We achieved successful intraoperative reversal of neuromuscular blockade (NMB) using a combination of sugammadex and neostigmine (with glycopyrrolate). However, MC was not avoided and reintubation was required on postoperative day 1. A 65-year-old male with a longstanding history of MG presented to the emergency department with complaints of abdominal pain, diarrhea, vomiting, chills, and fatigue for three days. A computed tomography (CT) scan of the abdomen showed acute appendicitis, for which he underwent a laparoscopic appendectomy on hospital day 1. The patient received successful general anesthesia with a rapid sequence induction using a smaller than average dose of rocuronium, given his history of MG. At the conclusion of the case, sugammadex followed by neostigmine/glycopyrrolate and a subsequent dose of sugammadex were given, with reversal of NMB. The patient was successfully extubated but required reintubation on postoperative day 1 for hypercapnic respiratory failure. Our case report on this patient with MG yields two topics that have not been extensively examined. First, dual therapy with sugammadex and neostigmine/glycopyrrolate may provide significant clinical benefit over individual therapy for NMBA reversal, given that their mechanisms of action are different and particularly when sugammadex is given prior to neostigmine/glycopyrrolate. Second, anesthesia literature is lacking on MG patients undergoing emergency surgeries. While sugammadex has been promising in medically optimized non-emergent surgeries, we discuss here a case where sugammadex failed to prevent MC in the emergency surgery setting and a look into what may provide patients with the best chance for avoiding postoperative MC.
Experimental studies of quantum chaos with trapped cesium

Dedicated my parents for their never ending support no matter what. Acknowledgments I am very grateful to have had the good fortune of working in the Atom Optics Laboratory of Mark Raizen at the University of Texas. Mark's dedication not only to physics, but to his family, his students, and the physics department provided both inspiration and challenge. His enthusiasm has provided this lab with a constant supply of both the creative and material wealth necessary for the tremendous success we've all enjoyed. One Mark's most important talents is his ability to hire talented people who can work together pleasantly and fruitfully. Though we often joke about not having a life as grad students, my coworkers in this lab have been a constant source of support, entertainment, and professional collaboration. I would like to thank Pat Morrow who got me started in this lab, and taught me the in's and out's of daily lab operation. I would also like to thank John Robinson who provided a wonderful example to follow as a person and a physicist, as well as patient and endless help. Our postdoc Fred Moore not only was an amazing experimentalist with an uncanny intuition for physics, but he could sometimes beat me at pool. Two of my contemporaries worked on the other experiment, but became great friends. Cyrus Bharucha had a wonderful ability to organize a variety of complex physical concepts into simple and intuitive packages. He was always ready to help and cheerfully at that. Kirk Madison could take the best notes in the world. But more than that he was always able to come away from any talk with the basic concepts of the subject, and his own connections to other v topics in physics. I feel very fortunate that he found time for me both in and out of the lab. He is a unique individual, and a good friend. This success of these experiments would not have been possible without the tireless help of two amazing individuals who worked with me on building this experiment. Dan Steck is the most talented and productive student I have known. He has an ever expanding wealth of knowledge, and is always willing to share when asked. He is responsible for most of the theoretical background we've uncovered, all of the simulations we present, and many of the experimental designs we used. His patient explanations of physics, …
Pharmacologic screen identifies active combinations with BET inhibitors and LRRK2 as a novel putative target in lymphoma

Inhibitors of the Bromo‐ and Extra‐Terminal domain (BET) family proteins have strong preclinical antitumor activity in multiple tumor models, including lymphomas. Limited single‐agent activity has been reported in the clinical setting. Here, we have performed a pharmacological screening to identify compounds that can increase the antitumor activity of BET inhibitors in lymphomas.
Time–Frequency Feature Enhancement of Moving Target Based on Adaptive Short-Time Sparse Representation

Accurate time–frequency (TF) feature extraction of moving target is a challenging task due to the poor resolution and serious cross-terms of the conventional TF analysis (TFA) methods. In this letter, an effective TFA algorithm based on the adaptive short-time sparse representation (ASTSR) is proposed to enhance the TF feature of moving target. First, the limitation of the Fourier-transform-based short-time TFA is revealed from the motion approximation perspective. Then, to achieve accurate motion approximation, the width of the analysis window is determined adaptively by minimizing the bandwidth of each short-time signal individually. Finally, TF representation (TFR) with high energy concentration is obtained using the sparsity of these signal segments in the chirp dictionary. Comparisons indicate that the ASTSR provides high-resolution TFRs without producing interference terms at an acceptable computational cost while performing well in weak component expressing and signal denoising. Furthermore, an ISAR imaging example confirms the potential of the proposed method.
BTI Aging Influence on Charge Pump Circuits

Charge pumps are widely used in modern nanometer technology circuits. Due to the high voltage levels that are generated in the internal nodes of these circuits, the influence of bias temperature instability (BTI) phenomena on their aging is expected to be substantial. In this paper we study the BTI related aging of various charge pump circuits and aging related simulation comparisons are presented.
Identification and Inference for Econometric Models: Essays in Honor of Thomas Rothenberg

IDENTIFICATION AND INFERENCE FOR ECONOMETRIC MODELS ESSAYS IN HONOR OF THOMAS ROTHENBERG PDF Are you looking for Ebook identification and inference for econometric models essays in honor of thomas rothenberg PDF? You will be glad to know that right now identification and inference for econometric models essays in honor of thomas rothenberg PDF is available on our online library. With our online resources, you can find identification and inference for econometric models essays in honor of thomas rothenberg or just about any type of ebooks, for any type of product.
Formation energetics/dynamics of icosahedral clusters in supercooled metallic liquids in the dynamic equilibrium regime: Gibbs free energy, entropy, enthalpy, and connection to coordination shells

Icosahedral (ICO) clusters are known to exist in many supercooled metallic liquids and believed to play an important role in stabilizing the liquid before it transitions into a glassy, crystalline or quasicrystalline solid. However, a detailed understanding of their formation energetics/dynamics is currently lacking and a set of key questions regarding these clusters remains to be answered. Here, we report our study on the formation energetics/dynamics of ICO clusters in liquid Cu_64Zr_36 and Ta by combining MD simulations with statistical and theoretical analysis. We present the formation Gibbs free energy, entropy, enthalpy of ICO clusters in the two liquids in the dynamic equilibrium regime ( T > 0.75 T _m), determine the size of the spatial domain (number of coordination shells) surrounding the clusters from which the formation enthalpy is originated, and discuss the results in connection with liquid composition, degree of randomness, potential energy landscape, and glass transition. Graphical abstract
Postnatal Dexamethasone Therapy Impairs Brown Adipose Tissue Thermogenesis and Autophagy Flux in Neonatal Rat Pups

Rationale: Very preterm infants may require dexamethasone (Dex) for facilitating extubation or treating bronchopulmonary dysplasia. However, Dex may result in disturbance of metabolisms. This study was to investigate the effects of postnatal short course Dex exposure on brown adipose tissue (BAT) in neonatal rats. Method: Neonatal rats received either three consecutive doses of daily Dex (0.2 mg/kg/day) or saline from postnatal P1 to P3. We investigated the effects of Dex on BAT including thermogenesis, mitochondrial dynamics and autophagy flux. We also compared diurnal temperature variation between preterm infants who received systemic corticosteroid and their treatment-naïve controls. Results: Postnatal Dex treatment induced growth retardation, BAT whitening, UCP1 downregulation and cold intolerance in neonatal rats. BAT mitochondria were damaged, evident by loss of normal number, structure, and alignment of cristae. Mitochondrial fission-fusion balance was disrupted and skewed toward increased fusion, reflected by increased OPA1 and MFN2 and decreased DRP1, FIS1 and phosphorylated MFF protein levels. Autophagosome synthesis was increased but clearance was inhibited, indicated by accumulation of p62 protein after Dex treatment and no further increase of LC3-II after chloroquine co-treatment. While autophagy modulators, including chloroquine and rapamycin, did not improve UCP1 downregulation and BAT whitening, AMPK activators could partially rescue these damages. We also demonstrated that preterm infants had higher diurnal temperature variation during corticosteroid treatment. Conclusions: Postnatal short course Dex impaired BAT mitochondrial function and autophagy flux in rat pups. AMPK activators had the potential to rescue the damage.
A three‐phase laminated anisotropic elliptical inhomogeneity with internal uniform stress resultants

We use the Stroh octet formalism for the coupled stretching and bending deformations of Kirchhoff laminated anisotropic thin plates together with the complex variable formulations of the decoupled stretching and bending deformations of Kirchhoff homogeneous isotropic thin plates to study the internal stress resultants inside a laminated anisotropic elliptical inhomogeneity bonded to a surrounding infinite laminated anisotropic matrix through a confocal interphase layer composed of a homogeneous isotropic plate when the matrix is subjected to uniform remote membrane stress resultants and bending moments. We prove that for given geometric and material parameters of the composite, the internal stress resultants inside the elliptical inhomogeneity are uniform when four specific conditions on the remote loading are satisfied. Furthermore, the internal uniform elastic field is determined in real‐form in terms of the two 8 × 8 fundamental elastic plate matrices for both the inhomogeneity and the matrix and the three 4 × 4 real matrices S, H, and L for the matrix.
Laba Bersih Sebagai Mediator Pengaruh Total Aset dan Total Liabilitas Terhadap Price to Book Value pada Perusahaan Sub Sektor Farmasi Di Bursa Efek Indonesia

This purpose of the research is to know and analyze net profit as mediator of effect to total assets and total liabilities on price to book value at pharmaceutical sub-sector companies in the Indonesia stock exchange. That research is using data of secondary from annual financial statements. The purposive sampling method used with four companies that are sampled at pharmaceutical sub-sector companies in the Indonesia stock exchange period 2015-2019. Data analysis in this research uses path analysis with SPSS software. The resulting research informs : 1) total assets and total liabilities simultaneously have significant effect on net profit, 2) total asset has positive and significant effect on net profit, 3) total liabilities has negative and significant effect on net profit, 4) total assets and total liabilities simultaneously have significant effect on price to book value, 5) total assets has positive and significant effect on price to book value, 6) total liabilities has positive and insignificant effect on price to book value, 7) net profit has positive and insignificant effect on price to book value and 8) indirectly total asset and total liabilities through net profit have insignificant effect on price to book value.
The host galaxies of radio-loud AGN: colour structure

We construct a sample of 3,516 radio-loud host galaxies of active galactic nuclei (AGN) from the optical Sloan Digital Sky Survey (SDSS) and Faint Images of the Radio Sky at Twenty cm (FIRST). These have 1.4 GHz luminosities in the range 10E23-1025 WHz^{-1}, span redshifts 0.02 2.22 mag). Optical emission line ratios (at >3 sigma) are used to remove type 1 AGN and star-forming galaxies from the radio sample using BPT diagnostics. For comparison, we select a sample of 35,160 radio-quiet galaxies with the same r*-band magnitude-redshift distribution as the radio sample. We also create comparison radio and control samples derived by adding the NRAO VLA Sky Survey (NVSS) to quantify the effect of completeness on our results. We investigate the effective radii of the surface brightness profiles in the SDSS r and u bands in order to quantify any excess of blue colour in the inner region of radio galaxies. We define a ratio R=r_{e}(r)/r_{e}(u) and use maximum likelihood analysis to compare the average value of R and its intrinsic dispersion between both samples. R is larger for the radio-loud AGN sample as compared to its control counterpart, and we conclude that the two samples are not drawn from the same population at >99% significance. Given that star formation proceeds over a longer time than radio activity, the difference suggests that a subset of galaxies has the predisposition to become radio loud. We discuss host galaxy features that cause the presence of a radio-loud AGN to increase the scale size of a galaxy in red relative to blue light, including excess central blue emission, point-like blue emission from the AGN itself, and/or diffuse red emission. We favour an explanation that arises from the stellar rather than the AGN light.