Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of Multiparametric US of the Liver for the Evaluation of Nonalcoholic Steatohepatitis.

Background Nonalcoholic steatohepatitis (NASH) is diagnosed with histopathologic testing, but noninvasive surrogate markers are desirable for screening patients who are at high risk of NASH. Purpose To investigate the diagnostic performance of dispersion slope, attenuation coefficient, and shear-wave speed measurements obtained using two-dimensional (2D) shear-wave elastography (SWE) in assessing inflammation, steatosis, and fibrosis and in the noninvasive diagnosis of NASH in patients suspected of having nonalcoholic fatty liver disease (NAFLD). Materials and Methods This prospective study collected data from 120 consecutive adults who underwent liver biopsy for suspected NAFLD and were enrolled between April 2017 and March 2019. Three US parameters (dispersion slope [(m/sec)/kHz], attenuation coefficient [dB/cm/MHz], and shear-wave speed [in meters per second]) were measured using a 2D SWE system immediately before biopsy. The biopsy specimens were scored by one expert pathologist according to the Nonalcoholic Steatohepatitis Clinical Research Network criteria (119 participants underwent a histologic examination). Diagnostic performance was assessed using the area under the receiver operating characteristic curve (AUC) for the categories of inflammation, steatosis, and fibrosis. Results One hundred eleven adults (mean age, 53 years ± 18 [standard deviation]; 57 men) underwent a US examination. Dispersion slope enabled the identification of lobular inflammation, with an AUC of 0.95 (95% confidence interval [CI]: 0.91, 0.10) for an inflammation grade greater than or equal to A1 (mild), 0.81 (95% CI: 0.72, 0.89) for an inflammation grade greater than or equal to A2 (moderate), and 0.85 (95% CI: 0.74, 0.97) for an inflammation grade equal to A3 (marked). Attenuation coefficient enabled the identification of steatosis, with an AUC of 0.88 (95% CI: 0.80, 0.97) for steatosis grade greater than or equal to S1 (mild), 0.86 (95% CI: 0.79, 0.93) for steatosis grade greater than or equal to S2 (moderate), and 0.79 (95% CI: 0.68, 0.89) for steatosis grade equal to S3 (severe). Shear-wave speed enabled the identification of fibrosis, with an AUC of 0.79 (95% CI: 0.69, 0.88) for fibrosis stage greater than or equal to F1 (portal fibrosis), 0.88 (95% CI: 0.82, 0.94) for fibrosis stage greater than or equal to F2 (periportal fibrosis), 0.90 (95% CI: 0.84, 0.96) for fibrosis stage greater than or equal to F3 (septal fibrosis), and 0.95 (95% CI: 0.91, 0.99) for fibrosis stage equal to F4 (cirrhosis). The combination of dispersion slope, attenuation coefficient, and shear-wave speed showed an AUC of 0.81 (95% CI: 0.71, 0.91) for the diagnosis of NASH. Conclusion Dispersion slope, attenuation coefficient, and shear-wave speed were found to be useful for assessing lobular inflammation, steatosis, and fibrosis, respectively, in participants with biopsy-proven nonalcoholic fatty liver disease. © RSNA, 2020 Online supplemental material is available for this article.
Isolated Exercise-Induced Pulmonary Hypertension Associates with Higher Cardiovascular Risk in Scleroderma Patients

Background and Aim: Isolated exercise-induced pulmonary hypertension (ExPH) associates with cardiovascular (CV) events in patients with left heart disease. We investigated its prognostic significance in scleroderma patients at risk for pulmonary arterial hypertension (PAH). Methods: In 26 consecutive scleroderma female patients with either low (n = 13) or intermediate probability (n = 13) of pulmonary hypertension (PH) at rest, we evaluated, both at time 0 and 1 year, prognostic determinants of CV risk: onset or progression of heart failure/syncope; worsening of functional class; functional performance at the 6-minute walking test and at cardiopulmonary exercise test; right atrial area; and pericardial effusion. We assigned a severity score 1–3 to each prognostic determinant, derived an overall CV risk score, and its 0–1 year change. Isolated ExPH during the cardiopulmonary exercise test (CPET) was defined as absence of PH at rest, reduced peak VO2, VE/VCO2 >30 at anaerobic threshold, reduced O2 pulse, and ΔVO2/ΔW <9 mL/min/W. We then correlated ExPH at time 0 with clinical worsening (risk score increase >20% after 1 year). Results: ExPH was strongly associated with clinical worsening compared to patients without ExPH (p = 0.005). In patients without ExPH, none had > 20% increased CV risk score after 1 year. Conversely, about 50% of patients with ExPH had such an increase, suggesting a worsening of prognosis. Conclusions: Isolated ExPH associates with higher cardiovascular risk and thus clinical worsening in scleroderma patients. The assessment of ExPH by CPET can thus contribute to a better risk stratification and the planning of a more adequate follow-up.
Insights into drylands biocrust microbiome: geography, soil depth, and crust type affect biocrust microbial communities and networks in Mojave Desert, USA.

Biocrusts are the living skin of drylands, comprising diverse microbial communities that are essential to desert ecosystems. Despite extensive knowledge on biocrust ecosystem functions and lichen and moss biodiversity, little is known about factors structuring diversity among their microbial communities. We used amplicon-based metabarcode sequencing to survey microbial communities from biocrust surface and subsurface soils at 4 sites located within the Mojave Desert. Five biocrust types were examined: Light-algal/Cyanobacteria, Cyano-lichen, Green-algal lichen, Smooth-moss, and Rough-moss crust types. Microbial diversity in biocrusts was structured by several characteristics 1) central versus southern Mojave sites displayed different community signatures, 2) indicator taxa of plant associated fungi (plant pathogens and wood saprotrophs) were identified at each site, 3) surface and subsurface microbial communities were distinct, and 4) crust types had distinct indicator taxa. Network analysis ranked bacteria-bacteria interactions as the most connected of all within-domain and cross-domain interaction networks in biocrust surface samples, with Actinobacteria, Proteobacteria, Cyanobacteria, and Ascomycota as hubs among all phyla. Specifically, the genera with highest node degree was Pseudonocardia sp. (Pseudonocardiales, Actinobacteria) in bacteria and Alternaria sp. (Pleosporales, Ascomycota) among fungal genera. Our findings provide crucial insights for dryland microbial community ecology, conservation, and sustainable management.
Comorbid Sleep Disturbance in Adolescents with Functional Abdominal Pain

ABSTRACT Objective/Background Sleep disturbances have been commonly reported as comorbid in youth with pain conditions, but prior research specific to functional abdominal pain (FAP) is limited. This study describes individual factors associated with increased risk for sleep disturbance and characterizes the relationship between sleep disturbance and pain-related variables. Participants Participants included 278 adolescents (age 11 to 17 years, M age = 15 years; 89% Caucasian; 65% female) with FAP. Methods Participants reported on sleep disturbances, abdominal pain severity, functional disability, somatic symptoms, and healthcare utilization. Results Female adolescents reported greater sleep disturbance than male adolescents (t(276) = 5.52, p < . 001, Cohen’s d = 0.70) and increased age was associated with greater sleep disturbance (r =.20, p =.001). In hierarchical regressions controlling for age, sex, and abdominal pain, greater sleep disturbance was significantly associated with greater functional disability (β =.32), non-gastrointestinal somatic symptoms (β =.35), and emergency department visits (β =.29). Conclusions Results suggest that sleep disturbance is common and should be assessed in youth presenting with FAP and may be a potential target for intervention.
Appendix to SpaceEx: Scalable Veriﬁcation of Hybrid Systems

In SpaceEx: Scalable Veriﬁcation of Hybrid Systems , we present a scalable reachability algorithm for hybrid systems with piecewise aﬃne, non-deterministic dynamics. It combines polyhedra and support function representations of continuous sets to compute an overapproximation of the reachable set of states in the form of template polyhedra. The algo-rithm improves over previous work by using variable time steps, adapted separately for each template direction to guarantee a given error bound. In addition, we propose coordinate transformations to reduce the approximation error and a clustering technique to avoid an explosion in the number of continuous sets. The algorithm is implemented as part of SpaceEx, a new veriﬁcation platform for hybrid systems, available at spaceex.imag. fr . Experimental results of full ﬁxed-point computations with hybrid systems with more than 100 variables illustrrate the scalability of the approach.
The effect of linguistic modification on English as a second language (ESL) nursing student retention

Abstract English-as-a-second-language (ESL) nursing students fail out of nursing programs at a far higher rate than native English speakers. There are many reasons for this trend, however academic failure related to poor performance on multiple-choice (MC) exams, is the most common. Objective The purpose of this interventional comparative research study was to determine the effect of linguistic modification (LM) of MC exam questions on score and timing of ESL compared to native English-speaking nursing students. Method Two-factor analysis of variance and a mixed-effects regression were applied to the data from 69 participants. Results Statistical significance was noted as related to time. All students took significantly less time to complete the LM questions in comparison to the standard questions. Conclusion LM is a process that should be used by nursing faculty to create fair evaluation instruments for all nursing students.
Expression of NF‐κB, IL‐6, and IL‐10 genes, body composition, and hepatic fibrosis in obese patients with NAFLD—Combined effects of oleoylethanolamide supplementation and calorie restriction: A triple‐blind randomized controlled clinical trial

Nonalcoholic fatty liver disease (NAFLD) is one of the most common noncommunicable diseases worldwide. The present study aimed to investigate the effects of oleoylethanolamide (OEA) supplementation combined with calorie restriction on inflammation, body composition, and hepatic fibrosis among obese patients with NAFLD. In this 12‐week randomized clinical trial, 76 obese patients newly diagnosed with NAFLD were randomly allocated into either OEA or placebo group. The weight‐loss diet was also designed for both groups. Pre‐ and postintervention messenger RNA expression levels of the transcription factor nuclear factor‐κB (NF‐κB), interleukin‐6 (IL‐6) and IL‐10, body composition, and NAFLD fibrosis score were assessed. At the end of the study, the OEA group showed lower NF‐κB and IL‐6 expression levels compared to the placebo (p < .01). However, IL‐10 expression level was approximately twofold higher in the OEA group compared to the placebo group (p = .008). A significant reduction was observed in the fat mass of the OEA group compared to the placebo (p = .044) postintervention. In addition, OEA supplementation led to a significant increase in fat‐free mass in the OEA group compared to the placebo (p = .032). A remarkable increase was observed in resting metabolic rate (RMR) in the OEA group (p = .009); however, it was not found in the placebo group. There were no significant between‐group differences in RMR postintervention. In addition, no significant within‐and between‐group differences were observed in the NAFLD fibrosis score at the end of the trial. Treatment with OEA along with weight‐loss intervention could significantly improve inflammation and body composition in patients with NAFLD.
Triarylpyridine Compounds and Chloroquine Act in Concert to Trigger Lysosomal Membrane Permeabilization and Cell Death in Cancer Cells

Lysosomes play a key role in regulating cell death in response to cancer therapies, yet little is known on the possible role of lysosomes in the therapeutic efficacy of G-quadruplex DNA ligands (G4L) in cancer cells. Here, we investigate the relationship between the modulation of lysosomal membrane damage and the degree to which cancer cells respond to the cytotoxic effects of G-quadruplex ligands belonging to the triarylpyridine family. Our results reveal that the lead compound of this family, 20A promotes the enlargement of the lysosome compartment as well as the induction of lysosome-relevant mRNAs. Interestingly, the combination of 20A and chloroquine (an inhibitor of lysosomal functions) led to a significant induction of lysosomal membrane permeabilization coupled to massive cell death. Similar effects were observed when chloroquine was added to three new triarylpyridine derivatives. Our findings thus uncover the lysosomal effects of triarylpyridines compounds and delineate a rationale for combining these compounds with chloroquine to increase their anticancer effects.
The Definition of Informatics Competencies in Finnish Healthcare and Social Welfare Education

Finland is a world leader in the use of public electronic services. Continuous improvement to competencies is a prerequisite for the success of digitalisation in the service development sector. The increasing use of information technology in health and social care needs to be taken into account in the education of the health and social care sector work force. The mandate of the national SotePeda 24/7 project is to identify and define the informatics competencies required for multidisciplinary education of this sector in Finland. The project has adapted international recommendations for use in the national context. The national recommendation covers 12 areas of competency and related content. In addition to defining competencies, the project has produced a toolbox of materials for use by educators of these topics in universities that cover applied sciences and lifelong learning. The results of the project are expected to significantly improve the preparedness of graduating health and social care and related engineering and business sector students to make full use information technology, all of which benefits the national health and social welfare system.
Source attribution of human echinococcosis: A systematic review and meta-analysis

Background A substantial proportion of echinococcosis transmission to humans via contamination of food has been assumed. However, the relative importance of food as a transmission vehicle has previously been estimated through expert opinion rather than empirical data. Objective To find and evaluate empirical data that could be used to estimate the source attribution of echinococcosis, in particular the proportion that is transmitted through contaminated food. Methods A systematic review was undertaken to identify reports on the risk factors for human cystic (CE) and alveolar (AE) echinococcosis. Data bases searched included PubMed, Scopus, Web of Knowledge, Cab Direct, Science Direct, Google Scholar, eLIBRARY.RU, CyberLeninka, CNKI and VIP. Search terms included Echinococc*, hydatid, epidemiology, logistic regression, risk factors, odds ratio, relative risk, risk factors. Reports, including grey literature where available, that had suitable data were selected and data were extracted. The main pathways of transmission were hypothesised to be contact with the definitive host, contaminated water, contaminated food and contaminated environment (other than food). For each study the attributable fraction for these potential sources of infection was calculated from the data presented. A meta-analysis was then undertaken to obtain pooled estimates for the relative contribution of these transmission pathways. Results Data from 28 cross-sectional studies and 14 case-control studies were extracted. There was strong evidence for transmission by direct contact with dogs for both CE and AE. The estimated attributable fractions were 26.1% (CI 13.8%-39.6%) and 34.4% (CI 20.7% -48.2%) respectively. Transmission through contaminated water was estimated to be responsible for approximately 29.4% (CI 12.1%-51.7%) for CE and 24.8% (CI 10.6% to 42.6%) for AE. Contaminated food may be responsible for approximately 23.4% of CE cases (CI 2.1%-47.3%). Globally, there was insufficient evidence to conclude AE can be transmitted by food, although case control studies from low human incidence areas suggested that possibly 32.5% (CI 10.0%-53.2%) could be transmitted by food. There was also insufficient evidence that direct contact with foxes was a significant source of human disease. There were no suitable studies with a risk of environmental contact reported, but the residual attributable fraction thatwould likely include this pathway was approximately 21.1% for CE and 11.1% for AE. Conclusions The results support the hypothesis that dog contact and drinking contaminated water are major pathways of transmission of both CE and AE. For contaminated food, the results are less consistent, but suggest that it is an important transmission pathway and provide better evidence than expert elicitations as previously used.
Using Visual Reflective Diaries of Photographs of School Buildings as a Tool for Empowering Students in Teacher Training

This article explores the uses of photography as a basis for creating a reflective diary for students in teacher training programs. The students engage in creating still photographs of the school building of their placement, during various stages of the course. The study focuses on the analysis of selected photographs of three case studies, in conjunction with written narratives, which are integrated in the visual diaries. The aim of the study is to create an alternative approach for modeling student supervision in the second year of teacher training, enabling freedom of expression that encourages personal professional growth through the use of photography.
A simple area-based model for predicting airborne LiDAR first returns from stem diameter distributions: an example study in an uneven-aged, mixed temperate forest

Tree size distributions are of fundamental importance in forestry. Airborne laser scanning (i.e., light detection and ranging, LiDAR) provides high-resolution information on canopy structure and may have potential as a tool for mapping and monitoring tree stem diameter distributions across forest landscapes. We present an area-based allometric model (with three levels of species specificity) that links ground-based plot data to the height distribution of LiDAR first returns, demonstrating the approach with survey data from a mixed, uneven-aged forest in central Ontario, Canada. Our model translates stem diameters into estimates of exposed crown area within 1 m height intervals; we then compared those estimates with the height distribution of LiDAR first returns. This basic approach gave reasonable goodness of fits (root mean squared error = 32%), but accuracy was improved by adding mechanistic features (root mean squared error = 17%) to adjust crown shapes and crown permeability and allow for crown overla.
Seed Germination Ecology of Purple-Leaf Button Weed (Borreria ocymoides) and Indian Heliotrope (Heliotropium indicum): Two Common Weeds of Rain-Fed Rice

Abstract Purple-leaf button weed and Indian heliotrope are widespread and common weed species of rain-fed rice in many tropical countries. The influence of various environmental factors on seed germination of these species was studied. Seeds of both species germinated at a range of alternating temperatures (25/15, 30/20, and 35/25 C day/night). Germination of purple-leaf button weed was similar among light conditions after an after-ripening period of 3 mo, whereas germination of Indian heliotrope was always greater in light. Seed germination of both species was not affected by a high level of salt and a range of pH between 5 and 9, but was sensitive to high degrees of water stress. Seed burial strongly inhibited germination and emergence of these species. Seedling emergence of purple-leaf button weed (82 to 86%) and Indian heliotrope (70%) was optimal when seeds were sown in the top 0.2-cm soil layer. A burial depth of 2 cm completely inhibited emergence of Indian heliotrope, whereas, for purple-leaf button weed, this depth was 5 cm. Most of these seeds germinated, however, when brought to the soil surface. The information gained from this study would help in predicting the potential of these species for spreading into new areas, and could contribute to their control. Nomenclature: Purple-leaf button weed, Borreria ocymoides (Burm. f.) Dc. ; Indian heliotrope, Heliotropium indicum L. HEIN; rice, Oryza sativa L.
Perceptual Evaluation of Signal-to-Noise-Ratio-Aware Dynamic Range Compression in Hearing Aids

Dynamic range compression is a compensation strategy commonly used in modern hearing aids. Fast-acting systems respond relatively quickly to the fluctuations in the input level. This allows for more effective compression of the dynamic range of speech and hence enhanced the audibility of its low-intensity components. However, such processing also amplifies the background noise, distorts the modulation spectra of both the speech and the background, and can reduce the output signal-to-noise ratio (SNR). Recently, May et al. proposed a novel SNR-aware compression strategy, in which the compression speed is adapted depending on whether speech is present or absent. Fast-acting compression is applied to speech-dominated time–frequency (T-F) units, while noise-dominated T-F units are processed using slow-acting compression. It has been shown that this strategy provides a similar effective compression of the speech dynamic range as conventional fast-acting compression, while introducing fewer distortions of the modulation spectrum of the background and providing an improved output SNR. In this study, this SNR-aware compression strategy was compared with conventional fast- and slow-acting compression in terms of speech intelligibility and subjective preference in a group of 17 hearing-impaired listeners with varying degree of hearing loss. The results show a speech intelligibility benefit of the SNR-aware compression strategy over the conventional slow-acting system. Furthermore, the SNR-aware approach demonstrates an increased subjective preference compared with both conventional fast- and slow-acting systems.
Observations on the Breeding Biology of the Collared Crescentchest (Melanopareia torquata)

Abstract The Collared Crescentchest (Melanopareia torquata) is an endemic bird of the Cerrado (Family: Melanopareiidae), and is listed in the State of São Paulo, Brazil as “endangered”. We studied the breeding biology of Collared Crescentchest at two nests in the State of São Paulo, southeast Brazil. Males were identified genetically and equipped with radio-transmitters. The incubation period was 12–16 days and the nestling period was 12–14 days. Nestling body mass was measured every second day for the first 10 days. Males participated in incubation and helped with nesting care. Measurements of eggs and nests are compared to those from the single previously known nest. These data are the first for any member of the Family Melanopareiidae.