Miracle-dz/UniFAR-FTUs huggingface dataset:
Electronic Publication and the Narrowing of Science and Scholarship

Online journals promise to serve more information to more dispersed audiences and are more efficiently searched and recalled. But because they are used differently than print—scientists and scholars tend to search electronically and follow hyperlinks rather than browse or peruse—electronically available journals may portend an ironic change for science. Using a database of 34 million articles, their citations (1945 to 2005), and online availability (1998 to 2005), I show that as more journal issues came online, the articles referenced tended to be more recent, fewer journals and articles were cited, and more of those citations were to fewer journals and articles. The forced browsing of print archives may have stretched scientists and scholars to anchor findings deeply into past and present scholarship. Searching online is more efficient and following hyperlinks quickly puts researchers in touch with prevailing opinion, but this may accelerate consensus and narrow the range of findings and ideas built upon.
A Review of Wearable Solutions for Physiological and Emotional Monitoring for Use by People with Autism Spectrum Disorder and Their Caregivers

The goal of real-time feedback on physiological changes, stress monitoring and even emotion detection is becoming a technological reality. People in their daily life experience varying emotional states, some of which are negative and which can lead to decreased attention, decreased productivity and ultimately, reduced quality of life. Therefore, having a solution that continuously monitors the physiological signals of the person and assesses his or her emotional well-being could be a very valuable tool. This paper aims to review existing physiological and motional monitoring devices, highlight their features and compare their sensing capabilities. Such technology would be particularly useful for certain populations who experience rapidly changing emotional states such as people with autism spectrum disorder and people with intellectual disabilities. Wearable sensing devices present a potential solution that can support and complement existing behavioral interventions. This paper presents a review of existing and emerging products in the market. It reviews the literature on state-of-the-art prototypes and analyzes their usefulness, clinical validity, and discusses clinical perspectives. A small number of products offer reliable physiological internal state monitoring and may be suitable for people with Autism Spectrum Disorder (ASD). It is likely that more promising solutions will be available in the near future. Therefore, caregivers should be careful in their selection of devices that meet the care-receiver’s personal needs and have strong research support for reliability and validity.
Validation of model for end‐stage liver disease score to serum sodium ratio index as a prognostic predictor in patients with cirrhosis

Aim: To evaluate the prognostic ability of model for end‐stage liver disease (MELD) to serum sodium (SNa) ratio (MESO) index and to compare the predictive accuracy of the MESO index with the MELD score and the modified Child–Turcotte–Pugh (CTP) score for short‐term survival in cirrhotic patients.
Some advances on Sidorenko's conjecture

A bipartite graph H is said to have Sidorenko's property if the probability that the uniform random mapping from V(H) to the vertex set of any graph G is a homomorphism is at least the product over all edges in H of the probability that the edge is mapped to an edge of G . In this paper, we provide three distinct families of bipartite graphs that have Sidorenko's property. First, using branching random walks, we develop an embedding algorithm which allows us to prove that bipartite graphs admitting a certain type of tree decomposition have Sidorenko's property. Second, we use the concept of locally dense graphs to prove that subdivisions of certain graphs, including cliques, have Sidorenko's property. Third, we prove that if H has Sidorenko's property, then the Cartesian product of H with an even cycle also has Sidorenko's property.
Healing: A Theory and Practice

Inspired by the unitary-transformative paradigm and phenomenological research, and recognizing that caring must embrace the whole of what is, the authors present a theory and a practice of healing. They assume that healing is a natural process that comes from within the person, that to be human is to be concerned with meaning and that everything and everyone are interconnected. Three theoretical and practical processes are presented: “Breathing,” “Joining With What Is” and “Experiencing Self. ” Together the three assumptions and the three processes facilitate being fully who we are, being true to ourselves and consciously living the lives we desire to create. The authors share this work with full recognition that it is possible, realistic and worthwhile to grow into a fuller understanding of our true selves and of the power we really have as individuals, communities, professions, nations and a world. Life is a healing journey; embraced it is one that enriches our personal lives as well as the care that we provide. Nursing and our health care systems must embrace a whole perspective if we are to continue to deepen our knowledge and understanding of the experience of being human.
Roll-your-own cigarette use and smoking cessation behaviour: a cross-sectional population study in England

Objectives Roll-your-own (RYO) cigarettes have become popular in the UK and reduce the cost of smoking, potentially mitigating the impact of tax increases on quitting. We examined whether RYO cigarette use was associated with reduced motivation to quit smoking, incidence of quit attempts and quit success. Design Cross-sectional survey. Setting England. Participants 38 590 adults who reported currently smoking or having stopped within the past 12 months. Main outcome measures Motivation to quit smoking, quit attempt in the last year, motives for quitting and quit success were regressed onto RYO cigarette use, adjusting for sociodemographic variables and level of cigarette addiction. Mediation by weekly spending on smoking was tested. Results Compared with manufactured cigarette smokers, RYO smokers had lower odds of high motivation to quit (OR=0.77, 95% CI 0.73 to 0.81) or having made a quit attempt (OR=0.87, 95% CI 0.84 to 0.91). Among those who had attempted to quit smoking, quit success did not differ by cigarette type (OR=1.00, 95% CI 0.89 to 1.12), but RYO smokers were less likely to report cost of smoking as a motive to quit (OR=0.68, 95% CI 0.61 to 0.74). Spending on smoking mediated the association between RYO use and quit attempts (β=−0.02, SE=0.003, 95% CI −0.03 to −0.02). Conclusions In England, compared with smokers of manufactured cigarettes, RYO cigarette smokers appear to have lower motivation to quit and lower incidence of quit attempts but similar success of quit attempts. The lower cost of RYO smoking appears to mediate the lower incidence of quit attempts among RYO users.
Gender‐specific considerations in physical activity, thermogenesis and fat oxidation: implications for obesity management

With current ‘one‐size‐fits‐all’ obesity prevention and management strategies proving largely ineffective, the focus has shifted towards a more tailored, individualized approach. However, investigation of the mechanisms underlying inter‐individual variability in metabolic profile and response to intervention often yield conflicting results. Indeed, it is perhaps surprising that despite at least a century of recognition that sex hormones influence metabolism, firm conclusions regarding the effects of the menstrual cycle, hormonal contraception and menopause on many aspects of energy expenditure and substrate utilization remain to be drawn. In this review, we examine current evidence relating to gender‐specific considerations in the promotion of physical activity, thermogenesis and fat oxidation for body‐weight regulation, including the relationship between sex hormone status and non‐exercise activity thermogenesis – an energy expenditure compartment that is often overlooked in favour of traditional exercise/sport physical activities yet presents a viable target in the search for effective weight management.
Optimization techniques for novel c-Met kinase inhibitors

ABSTRACT Introduction: c-Met kinase plays an important part in the regulation of cell growth, invasion and anti-apoptosis. This enzyme is also an important target in cancer treatment. Through structural optimization and structure-activity studies of drugs currently on the market and those still in clinical trials, a great number of novel c-Met kinase inhibitors have been developed. This review focuses on recent developments in research regarding novel c-Met inhibitor synthesis, optimization, and structure-activity relationship (SAR) studies. Area covered: In this review, the authors discuss the representative research of c-Met inhibitors published in recent years. Furthermore, it provides background research of c-Met kinase inhibitors, the introduction of drugs on the market and in clinical research, and the research progress of novel small molecule inhibitors. In particular, this review emphasizes the important role of ‘5-atoms linker’ in the design of some novel c-Met enzyme inhibitors. Expert opinion: Discovering novel c-Met kinase inhibitors via natural product chemistry may become a new research field. Though it is difficult, the key to developing better c-Met kinase inhibitors is structural optimization.
Use of a genome-wide haploid genetic screen to identify treatment predicting factors: a proof-of-principle study in pancreatic cancer

The ability to develop a comprehensive panel of treatment predicting factors would significantly improve our ability to stratify patients for cytotoxic or targeted therapies, and prevent patients receiving ineffective treatments. We have investigated if a recently developed genome-wide haploid genetic screen can be used to reveal the critical mediators of response to anticancer therapy. Pancreatic cancer is known to be highly resistant to systemic therapy. Recently epigenetic changes have been shown to be a key determinant in the maintenance of subpopulations of cancer cells with high-level resistance to cytotoxic therapy. We show that in human pancreatic cancer cell lines, treatment with the potent class I histone deacetylase inhibitor, entinostat, synergistically enhances gemcitabine-induced inhibition of cell proliferation and apoptosis. Using a genome-wide haploid genetic screen, we identified deoxycytidine kinase (DCK) as one of the genes with the highest degree of insertional enrichment following treatment with gemcitabine and entinostat; DCK is already known to be the rate-limiting activating enzyme for gemcitabine. Immunoblotting confirmed loss of DCK protein expression in the resistant KBM7 cells. CRISPR/Cas-9 inactivation of DCK in pancreatic cancer cell lines resulted in resistance to gemcitabine alone and in combination with entinostat. We have identified gemcitabine and entinostat as a potential new combination therapy in pancreatic cancer, and in this proof-of-principle study we have demonstrated that a recently developed haploid genetic screen can be used as a novel approach to identify the critical genes that determine treatment response.
Rhinitis, sinusitis, and ocular allergy Sublingual allergen immunotherapy with a liquid birch pollen product in patients with seasonal allergic rhinoconjunctivitis with or without asthma

Oliver Pfaar, MD, Claus Bachert, MD, PhD, Piotr Kuna, MD, Petr Panzner, MD, PhD, M! aria D"zupinov! a, MD, MSc, MBA, Ludger Klimek, MD, Maroesja J. van Nimwegen, PhD, Johan D. Boot, PhD, Donghui Yu, PhD, Dirk Jan E. Opstelten, PhD, and Pieter-Jan de Kam, PhD, MBA Marburg, Mannheim, and Wiesbaden, Germany, Ghent, Belgium, Lodz, Poland, Pilsen, Czech Republic, Bardejov, Slovakia, and Leiden, The Netherlands
Residual Normality Assumption and the Estimation of Multiple Membership Random Effects Models

Abstract While conventional hierarchical linear modeling is applicable to purely hierarchical data, a multiple membership random effects model (MMrem) is appropriate for nonpurely nested data wherein some lower-level units manifest mobility across higher-level units. Although a few recent studies have investigated the influence of cluster-level residual nonnormality on hierarchical linear modeling estimation for purely hierarchical data, no research has examined the statistical performance of an MMrem given residual non-normality. The purpose of the present study was to extend prior research on the influence of residual non-normality from purely nested data structures to multiple membership data structures. Employing a Monte Carlo simulation study, this research inquiry examined two-level MMrem parameter estimate biases and inferential errors. Simulation factors included the level-two residual distribution, sample sizes, intracluster correlation coefficient, and mobility rate. Results showed that estimates of fixed effect parameters and the level-one variance component were robust to level-two residual non-normality. The level-two variance component, however, was sensitive to level-two residual non-normality and sample size. Coverage rates of the 95% credible intervals deviated from the nominal value assumed when level-two residuals were non-normal. These findings can be useful in the application of an MMrem to account for the contextual effects of multiple higher-level units.
The effectiveness of peer-supported interventions for encouraging dietary behaviour change in adults: a systematic review

Abstract Objective There is an urgent need to find effective methods of supporting individuals to make dietary behaviour changes. Peer-supported interventions (PSI) have been suggested as a cost-effective strategy to support chronic disease self-management. However, the effect of PSI on dietary behaviour is unclear. The present systematic review aimed to assess the effectiveness of PSI for encouraging dietary behaviour change in adults and to consider intervention characteristics linked with effectiveness. Design Electronic databases were searched until June 2018 for randomised controlled trials assessing the effectiveness of PSI compared with an alternative intervention and/or control on a dietary related outcome in adults. Following title and abstract screening, two reviewers independently screened full texts and data were extracted by one reviewer and independently checked by another. Results were synthesised narratively. Setting Randomised controlled trials. Participants Adult studies. Results The fifty-four included studies varied in participants, intervention details and results. More PSI reported a positive or mixed effect on diet than no effect. Most interventions used a group model and were lay-led by peer supporters. Several studies did not report intervention intensity, fidelity and peer training and support in detail. Studies reporting positive effects employed more behaviour change techniques (BCT) than studies reporting no effect; however, heterogeneity between studies was considerable. Conclusions As evidence was mixed, further interventions need to assess the effect of PSI on dietary behaviour, describe intervention content (theoretical basis, BCT, intensity and peer training/support) and include a detailed process evaluation.
Augmented Reality to Improve Surgical Simulation: Lessons Learned Towards the Design of a Hybrid Laparoscopic Simulator for Cholecystectomy

Hybrid surgical simulators based on augmented reality (AR) solutions benefit from the advantages of both the box trainers and the virtual reality simulators. This paper reports on the results of a long development stage of a hybrid simulator for laparoscopic cholecystectomy that integrates real and the virtual components. We first outline the specifications of the AR simulator and then we explain the strategy adopted for implementing it based on a careful selection of its simulated anatomical components, and characterized by a real-time tracking of both a target anatomy and of the laparoscope. The former is tracked by means of an electromagnetic field generator, while the latter requires an additional camera for video tracking. The new system was evaluated in terms of AR visualization accuracy, realism, and hardware robustness. Obtained results show that the accuracy of AR visualization is adequate for training purposes. The qualitative evaluation confirms the robustness and the realism of the simulator. In conclusion, the proposed AR simulator satisfies all the initial specifications in terms of anatomical appearance, modularity, reusability, minimization of spare parts cost, and ability to record surgical errors and to track in real-time the Calot's triangle and the laparoscope. Thus, the proposed system could be an effective training tool for learning the task of identification and isolation of Calot's triangle in laparoscopic cholecystectomy. Moreover, the presented strategy could be applied to simulate other surgical procedures involving the task of identification and isolation of generic tubular structures, such as blood vessels, biliary tree, and nerves, which are not directly visible.
Widened QRS-T Angle May Be a Measure of Poor Ventricular Stretch During Exercise Among On-duty Firefighters

Background: The spatial QRS-T angle is a measure of repolarization heterogeneity and may be a predictor of poor ventricular health. It is unknown whether a relationship exists between QRS-T angle and blood pressure (BP) during exercise. Objective: The purpose of this study was to evaluate the potential relationship between QRS-T angle and BP during exercise, which may be indicative of ventricular stretch. Methods: Ambulatory 12-lead 24-hour Holter electrocardiographic monitoring for QRS-T angle measurement was followed by exercise testing with BP (mm Hg) recordings taken preexercise, maximum achieved BP during exercise, and 2 minutes postexercise. Blood pressure recovery was calculated by subtracting the maximal and 2-minute postexercise BPs. Means (± standard deviation) and percentages are presented. Pearson correlations (r) among all QRS-T angles and all BP measures were performed. One-way analysis of variance was conducted on classification of QRS-T angle and all BP measures. Results: One hundred eleven firefighters (95.5% male; mean age, 44 years) were included in this analysis. Twenty-seven percent of the firefighters had either a borderline (100°–139°) or widened (≥140°) QRS-T angle. Although the analysis of variance was not statistically significant, a near–statistically significant negative correlation existed between QRS-T angle and maximum diastolic BP (r = −0.190, P = .05), and a statistically significant relationship existed between QRS-T angle and postexercise diastolic BP (r = −0.261, P = .008). Conclusions: A negative correlation existed between QRS-T angle and maximal diastolic BP and postexercise diastolic BP. Lower maximum diastolic BP during and after exercise may be a sign of poor ventricular stretch. A widened spatial QRS-T angle may represent poor ventricular stretch.
Toward Catalog of Enterprise Resource Planning (ERP) Implementation Benefits for Measuring ERP Success

The growth of information technology (IT) and trend of e-business transform the business and shifts the business focus from the production into integrated operations. As the impact, enterprises have to adjust themselves by implementing IT systems in their businesses, including develop an integrated application infrastructure named Enterprise Resource Planning (ERP). As a complete, integrated, and all-encompassing systems, ERP are designed to support the key functional areas of the organization and helping companies for reaching competitive advantage for their business. The importance of ERP and numbers of ERP advantages encourages many organizations worldwide to implement the systems and make large amount of investment. However, the ERP systems huge impact on the organization coupled with a potentially high risk of project resulting in various outcome for the companies, from gaining huge amount of profit to get huge disaster. Therefore, it should be imperative that proper evaluation be undertaken on ERP projects to identify, manage and realize the benefits of ERP and their contribution to organizations. This research aims to formulate a catalog of ERP implementation benefits to measure ERP implementation success in the organizations. The benefits catalog was developed by using the five dimensions from Shang and Seddon of ERP benefits framework and 73 subcategories of dimension from Ranti’s Generic IS/IT value. Initiated in an agricultural company Indonesia, the research identify the ERP bring benefit to the company in five dimension: operational, managerial, strategic, IT infrastructure, and organizational with the total of 25 categories and 41 subcategories were accepted.
Rethinking birdsong evolution: meta-analysis of the relationship between song complexity and reproductive success

The theory of sexual selection predicts a relationship between male sexual traits and reproductive success. This prediction has been tested extensively using the complexity of birdsong as a model for trait elaboration. However, contradictory results have emerged. Some studies have demonstrated that males with large repertoires enjoy a reproductive advantage, whereas other studies have failed to support this prediction. To make general inferences from this mixed evidence, we quantitatively reviewed the relevant literature using a meta-analytic approach. The mean effect size for the song/mating success association was significant, but the effects were generally weak, affected by publication bias, confounded by uncontrolled variables, and differing across the traits examined. Effect sizes were heterogeneous across studies due to species-specific effects, differences in mating systems, and song phenotypes. The degree of association between song complexity and reproductive success was independent of the strength of sexual selection, as assessed by the degree of polygyny and extrapair paternity. Our results highlight the importance of considering various biological factors to understand the role of repertoires in mediating mating success in different species. Copyright 2011, Oxford University Press.
Biodegradable polyurethane materials from bark and starch. II. Coating material for controlled‐release fertilizer

Biodegradable polyurethane foams (PUFs) as coating materials for the controlled release of fertilizer were prepared from a four-component system consisting of diisocyanate, polyester, Acacia mearnsi bark, and corn starch. Ammonium sulfate [(NH4)2SO4] was used as a fertilizer to evaluate the effects of the preparation conditions on the release ratio. The release ratio of (NH4)2SO4 decreased with an increasing amount of biomass in PUFs and increasing sizes of sample particles; the ratio increased with increasing doses of water, which was used as a foaming agent in the preparation of polyurethane, regardless of the amount of coating material. The remaining fertilizer in the polyurethane seemed to be released completely because the PUFs were degradable, to some extent, by soil microorganisms. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 2948–2952, 2002