Miracle-dz/UniFAR-FTUs huggingface dataset:
The Relationship between Cerebrovascular Reactivity and Cerebral Oxygenation during Hemodialysis

Significance Statement Patients with ESKD have a high burden of ischemic brain lesions related to decline in cerebral blood flow during hemodialysis. Preliminary studies in patients on hemodialysis noted impairment in cerebrovascular reactivity, a mechanism that regulates cerebral perfusion. We found that lower cerebrovascular reactivity was associated with greater decrease in cerebral oxygen saturation during hemodialysis, particularly when accounting for changes in systemic BP. These results suggest that testing cerebrovascular reactivity could be relevant to characterizing risk of cerebral ischemia during hemodialysis and the potential sequelae of brain injury and cognitive impairment over time. Visual Abstract Background Patients with kidney failure treated with hemodialysis (HD) may be at risk for cerebral hypoperfusion due to HD-induced BP decline in the setting of impaired cerebral autoregulation. Cerebrovascular reactivity (CVR), the cerebrovascular response to vasoactive stimuli, may be a useful indicator of cerebral autoregulation in the HD population and identify those at risk for cerebral hypoperfusion. We hypothesize that CVR combined with intradialytic BP changes will be associated with declines in cerebral oxygenation saturation (ScO2) during HD. Methods Participants completed the MRI scans on a non-HD day and cerebral oximetry during HD. We measured CVR with resting-state fMRI (rs-fMRI) without a gas challenge and ScO2 saturation with near-infrared spectroscopy. Regression analysis was used to examine the relationship between intradialytic cerebral oxygen desaturation, intradialytic BP, and CVR in different gray matter regions. Results Twenty-six patients on HD had complete data for analysis. Sixteen patients were men, 18 had diabetes, and 20 had hypertension. Mean±SD age was 65.3±7.2 years, and mean±SD duration on HD was 11.5±9.4 months. CVR in the anterior cingulate gyrus (ACG; P=0.03, r2=0.19) and insular cortex (IC; P=0.03, r2=0.19) regions negatively correlated with decline in intradialytic ScO2. Model prediction of intradialytic ScO2 improved when including intradialytic BP change and ultrafiltration rate to the ACG rsCVR (P<0.01, r2=0.48) and IC rsCVR (P=0.02, r2=0.35) models, respectively. Conclusions We found significant relationships between regional rsCVR measured in the brain and decline in intradialytic ScO2. Our results warrant further exploration of using CVR in determining a patient’s risk of cerebral ischemic injury during HD.
The impact of pubertal DHEA on the development of visuospatial oscillatory dynamics

The adolescent brain undergoes tremendous structural and functional changes throughout puberty. Previous research has demonstrated that pubertal hormones can modulate sexually dimorphic changes in cortical development, as well as age‐related maturation of the neural activity underlying cognitive processes. However, the precise impact of pubertal hormones on these functional changes in the developing human brain remains poorly understood. In the current study, we quantified the neural oscillatory activity serving visuospatial processing using magnetoencephalography, and utilized measures of dehydroepiandrosterone (DHEA) as an index of development during the transition from childhood to adolescence (i.e., puberty). Within a sample of typically developing youth (ages 9–15), a novel association between pubertal DHEA and theta oscillatory activity indicated that less mature children exhibited stronger neural responses in higher‐order prefrontal cortices during the visuospatial task. Theta coherence between bilateral prefrontal regions also increased with increasing DHEA, such that network‐level theta activity became more distributed with more maturity. Additionally, significant DHEA‐by‐sex interactions in the gamma range were centered on cortical regions relevant for attention processing. These findings suggest that pubertal DHEA may modulate the development of neural oscillatory activity serving visuospatial processing and attention functions during the pubertal period.
Quick Guide to Equations and Assumptions Estimating metastasis initiating cell ( MIC ) frequency

Metastasis is the defining feature of advanced malignancy, yet remains challenging to study in laboratory environments. Here we describe a high-throughput zebrafish system for comprehensive, in vivo assessment of metastatic biology. First, we generated several stable cell lines from melanomas of transgenic mitfa-BRAFV600E;p53−/− fish. We then transplanted the melanoma cells into the transparent casper strain to enable highly quantitative measurement of the metastatic process at single cell resolution. Using computational image analysis of the resulting metastases, we generated a metastasis score, μ, that can be applied to quantitative comparison of metastatic capacity between experimental conditions. Furthermore, image analysis also provided estimates of the frequency of metastasis-initiating cells (~1/120,000 cells). Finally, we determined that the degree of pigmentation is a key feature defining cells with metastatic capability. The small size and rapid generation of progeny combined with superior imaging tools make zebrafish ideal for unbiased high-throughput investigations of cell-intrinsic or microenvironmental modifiers of Corresponding Author: Richard White, M.D., Ph.D., Memorial Sloan Kettering Cancer Center, 1275 York Avenue, MB 424, New York, N.Y. 10065, Phone: 646-888-3415, whiter@mskcc.org. CONFLICT OF INTEREST DISCLOSURE: Leonard Zon is a founder and Scientific Advisory Board member of FATE Therapeutics and Scholar Rock. He has stock in both companies. HHS Public Access Author manuscript Cancer Res. Author manuscript; available in PMC 2016 October 15. Published in final edited form as: Cancer Res. 2015 October 15; 75(20): 4272–4282. doi:10.1158/0008-5472.CAN-14-3319. A uhor M anscript
of arrays on

Thermally responsive polymers present an interesting avenue for tuning the optical properties of nanomaterials on their surfaces by varying their periodicity and shape using facile processing methods. Gold bowtie nanoantenna arrays are fabricated using nanosphere lithography on prestressed polyole ﬁ n ( PO ) , a thermoplastic polymer, and optical properties are investigated via a combination of spectroscopy and electromagnetic simulations to correlate shape evolution with optical response. Geometric features of bowtie nanoantennas evolve by annealing at temperatures between 105 ° C and 135 ° C by releasing the degree of prestress in PO. Due to the higher modulus of Au versus PO, compressive stress occurs on Au bowtie regions on PO, which leads to surface buckling at the two highest annealing temperatures; regions with a 5 nm gap between bowtie nanoantennas are observed and the average reduction is 75%. Re ﬂ ectance spectroscopy and full-wave electromagnetic simulations both demonstrate the ability to tune the plasmon resonance wavelength with a window of approximately 90 nm in the range of annealing temperatures investigated. Surface-enhanced Raman scattering measurements demonstrate that maximum enhancement is observed as the excitation wavelength approaches the plasmon resonance of Au bowtie nanoantennas. Both the size and morphology tunability offered by PO allows for customizing optical response.
Edinburgh Research Explorer Genome Scan for Parent-of-Origin QTL Effects on Bovine Growth and Carcass Traits

Parent-of-origin effects (POE) such as genomic imprinting inﬂuence growth and body composition in livestock, rodents, and humans. Here, we report the results of a genome scan to detect quantitative trait loci (QTL) with POE on growth and carcass traits in Angus × Brahman cattle crossbreds. We identiﬁed 24 POE–QTL on 15 Bos taurus autosomes (BTAs) of which six were signiﬁcant at 5% genome-wide (GW) level and 18 at the 5% chromosome-wide (CW) signiﬁcance level. Six QTL were paternally expressed while 15 were maternally expressed. Three QTL inﬂuencing post-weaning growth map to the proximal end of BTA2 (linkage region of 0–9 cM; genomic region of 5.0–10.8 Mb), for which only one imprinted ortholog is known so far in the human and mouse genomes, and therefore may potentially represent a novel imprinted region.The detected QTL individually explained 1.4 ∼ 5.1% of each trait’s phenotypic variance. Comparative in silico analysis of bovine genomic locations show that 32 out of 1,442 known mammalian imprinted genes from human and mouse homologs map to the identiﬁed QTL regions. Although several of the 32 genes have been associated with quantitative traits in cattle, only two ( GNAS and PEG3 ) have experimental proof of being imprinted in cattle. These results lend addi-tional support to recent reports that POE on quantitative traits in mammals may be more common than previously thought, and strengthen the need to identify and experimentally validate cattle orthologs of imprinted genes so as to investigate their effects on quantitative traits.
THE INFLUENCE OF TECHNOLOGICAL PARAMETERS ON CHEMICAL COMPOSITION OF MOMORDICA CHARANTIA FRUITS

Bitter gourd ( Momordica charantia L.) is appreciated for the nutritional qualities and biochemical compounds of fruits that are rich in folic acid and vitamin C. In Asia this species is cultivated to heal many diseases of human body. Experiments regarding the influence of technological parameters on chemical composition of Momordica charantia fruits took place at University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Romania. Several determination concerning total yield, proteins, fibres, momordicine, charantin and vitamin C were made. The obtained results show that highest total yield was noted in case of variant conducted with two branches and organically fertilized. The content of protein is higher than in the fruits of common cucumber. Vegetable fiber and mineral content are higher compering with other succulent vegetables. The mature leaves bioactive compounds ratio is 2,5:1 for charantin and 2:1 for momordicine. The highest content of vitamin C (197.12 mg/100 dry substances) was detected in the fruits of variants conducted with one branch and organically fertilized. At the same variants the total acidity with superior level (11,6%) was noticed.
Visualization and ontology to analyse categorical attributes in geographic metadata

The paper addresses issues in the analysis of geographic metadata. Metadata, data about data, are used to maintain, organize, and provide information about geographic data and their analysis is an important task in geographic data searching activity. Due to the complexity and the diversity of the attributes of geographic metadata, the analysis of metadata can lead to the problems of data missing and of unfamiliarity with attributes. We propose an approach to analyse geographic metadata based on visual data mining techniques to facilitate the navigation in unfamiliar spaces and ontology to support user in the search criteria. In particular the analysis of categorical attributes of metadata is considered. Techniques and concepts of information visualisation, graphic interaction, data mining and ontology are analysed and exploited: the main idea is to integrate some of these techniques and concepts to facilitate data searching activity.
Autologous Cytokine-Induced Killer Cell Immunotherapy for Patients with High-Risk Diffuse Large B Cell Lymphoma After the First Complete Remission

Purpose: To evaluate whether autologous cytokine-induced killer (CIK) cell immunotherapy improves the prognosis of patients with high-risk diffuse large B cell lymphoma (DLBCL) after the ﬁ rst complete remission (CR). Patients and Methods: Peripheral blood mononuclear cells (PBMCs) were extracted from 20 patients with high-risk DLBCL (IPI ≥ 3) after the ﬁ rst CR. Twenty CR patients who were age- and sex-matched during the same period were selected as controls. PBMCs were cultured with IFN- γ , IL-2 and anti-CD3 mAb to generate CIK cells. These obtained cells were then transfused back into the patients; the transfusion was repeated every 3 months up to a total of four courses. Changes in peripheral blood lymphocyte subgroups and survival were assessed. Results: Compared with the baseline proportions, the proportion of CD3 + T cells, CD3 + CD8 + T cells, and NK cells in the peripheral blood were signi ﬁ cantly higher after transfusions ( p <0.05). The 5-year DFS was improved from 45.0 ± 11.1% to 79.3 ± 9.2% in the CIK group (HR favoring CIK, 0.29; 95% CI, 0.09 to 0.92; p = 0.035), and the 5-year OS was estimated at 90 ± 6.7% for CIK versus 55 ± 11.1% for control (HR favoring CIK, 0.20; 95% CI, 0.04 to 0.93; p = 0.040). No severe side effects were observed related to CIK treatment. Conclusion: Autologous CIK cell immunotherapy has emerged as a safe and ef ﬁ cacious option to improve the prognosis of patients with high-risk DLBCL after the ﬁ rst CR.
Taxonomy and distribution of epiphytic cacti in Uruguay - notes towards a checklist of Cactaceae of Uruguay, Part 3

The most recent treatments of the family Cactaceae for Uruguay are that of Arechavaleta (1905), Osten (1941), and Herter (1953-55). While the globular members of the family (Parodia [including Notocactus], Frailea, and Gymnocalycium) are relatively well known through numerous later individual publications, the epiphytic species of Lepismium and Rhipsalis are comparatively poorly-known. Based on herbarium material and recent collections, we present data on the geographical distribution and taxonomy for two species of Lepismium and two species of Rhipsalis. Lepismium cruciforme and Rhipsalis floccosa are new records for the flora of Uruguay. The occurrence of Epiphyllum phyllanthus in Uruguay could not be confirmed. ABSTRACT Mid-late Pleistocene fossil hominins such as Homo neanderthalensis and H. heidelbergensis are often described as having extensively pneuma- tized crania compared with modern humans. However, the signiﬁcance of pneumatization in recognizing patterns of phyletic diversiﬁcation and/or functional specialization has remained controversial. Here, we test the null hypothesis that the paranasal sinuses of fossil and extant humans and great apes can be understood as biological spandrels, i.e., their morphology reﬂects evolutionary, developmental, and functional constraints imposed onto the surrounding bones. Morphological description of well-preserved mid-late Pleistocene hominin specimens are contrasted with our comparative sample of modern humans and great apes. Results from a geometric morphometric analysis of the correlation between paranasal sinus and cranial dimensions show that the spandrel hypothesis cannot be refuted. However, visualizing speciﬁc features of the paranasal sinus system with methods of biomedical imaging and computer graphics reveals new aspects of patterns of growth and development of fossil homi- nins. Anat Rec, 000:000–000, 2008.
Near-earth binaries and triples: Origin and of spin-orbital

: In the near-Earth asteroid population, binary and triple systems have been discovered with mutual orbits that have significant eccentricities as well as large semimajor axes. All known systems with eccentric orbits and all widely separated primary-satellite pairs have rapidly rotating satellites. Here, we study processes that can elucidate the origin of these spin-orbital properties. Binary formation models based on rotational fissioning can reproduce asynchronous satellites on orbits with high eccentricities and a wide range of separations, but do not match observed properties. We explore whether any evolutionary mechanisms can link the spin and orbital parameters expected from post-fission dynamics to those observed today. We investigate four processes: tidal torques, radiative perturbations (BYORP), close planetary encounters, and Kozai oscillations. We find that a combination of post-fission dynamics and tidal evolution can explain nearly all the spin-eScholarship orbit properties in a sample of nine well-characterized near-Earth binaries and triples. The other mechanisms may act as well but are not required to explain the observed data. Lastly, we describe evolutionary pathways between observed spin-orbital states including synchronous and circular, asynchronous and circular, and asynchronous and eccentric configurations. ABSTRACT In the near-Earth asteroid population, binary and triple systems have been discovered with mutual orbits that have signiﬁcant eccentricities as well as large semi-major axes. All known systems with eccentric orbits and all widely-separated primary-satellite pairs have rapidly rotating satellites. Here we study processes that can elucidate the origin of these spin-orbital properties. Binary formation models based on rotational ﬁssioning can reproduce asynchronous satellites on orbits with high eccentricities and a wide range of separations, but do not match observed properties. We explore whether any evolutionary mechanisms can link the spin and orbital parameters expected from post-ﬁssion dynamics to those observed today. We investigate four processes: tidal torques, radiative perturbations (BYORP), close planetary encounters, and Kozai oscillations. We ﬁnd that a combination of post-ﬁssion dynamics and tidal evolution can explain nearly all the spin-orbit properties in a sample of nine well-characterized near-Earth binaries and triples. The other mechanisms may act but are not required to explain the observed data. Lastly, we describe evolutionary pathways between observed spin-orbital states including synchronous and circular, asynchronous and circular, and asynchronous and eccentric conﬁgurations.
Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M1‐acetylcholine receptor agonist: A randomized cross‐over trial

HTL0009936 is a selective M1 muscarinic receptor agonist in development for cognitive dysfunction in Alzheimer's disease. Safety, tolerability and pharmacokinetics and exploratory pharmacodynamic effects of HTL0009936 administered by continuous IV infusion at steady state were investigated in elderly subjects with below average cognitive functioning (BACF).
A New Hybrid Frequent Pattern-Apriori (FP-AP) Algorithm for High Utility Item Set Mining

: Frequent item set mining which deals with the items occurs at sequences of events, High utility item set mining is a confront process in frequent pattern mining. , Frequent Item set Mining (FIM) look at all the items having the equal priority and it is very difficult to find the High utility item (HUI) without any redundancy. If user is in need of finding the rare purchased product or to find the high profitable item that couldn’t not be done in frequent item set mining. To overthrown the concern in FIM, high utility items were calculated. The utility denotes the usefulness of the product and also represents the rarely purchased product of the users. Furthermore, in HUI, the huge number of outcome with high utility was composed. So, the user is not able to get the concise result. Meantime for a longer transaction the truncation technique was used which cause to information loss and the privacy is also a main issue. Hence to overcome this controversy, it is proposed to provide a High Utility Item without redundancy and to find the closest item set. Here, the proposed FP-AP algorithm which is the combination of frequent pattern and apriori algorithm.FP is proposed to split the longer transaction rather than truncated and also to find the high profitable item with privacy to that item set without redundancy. AP algorithm helps to provide a concise and lossless representation without affecting the utility.
The single CCA-adding enzyme of T. brucei has distinct functions in the cytosol and in mitochondria

-------------------------------------------------------------------------------------------------------------------------ABSTRACT tRNAs universally carry a CCA nucleotide triplet at their 3 ′ -ends. In eukaryotes, the CCA is added post-transcriptionally by the CCA-adding enzyme (CAE). The mitochondrion of the parasitic protozoan Trypanosoma brucei lacks tRNA genes and therefore imports all of its tRNAs from the cytosol. This has generated interest in the tRNA modifications and their distribution in this organism, including how CCA is added to tRNAs. Here, using a BLAST search for genes encoding putative CAE proteins in T. brucei , we identified a single ORF, Tb927.9. 8780, as a potential candidate. Knockdown of this putative protein, termed TbCAE, resulted in the accumulation of truncated tRNAs, abolished translation, and inhibited both total and mitochondrial CCA-adding activities, indicating that TbCAE is located both
Running Head : NOSTALGIA PROMOTES INTRINSIC MOTIVATION 1 Nostalgia Promotes Intrinsic Motivation and Effort in the Presence of Low Interactional

We examined whether nostalgia increases intrinsic motivation in situations of low (vs. high) interactional justice, with downstream implications for work effort. In Study 1, we tested employees of various organizations using experience sampling methodology (ESM). High (vs. low) momentary nostalgia predicted stronger momentary intrinsic motivation, particularly when chronic interactional justice was low (vs. high). In Study 2, another ESM study among employees, we induced nostalgia. Induced nostalgia (vs. control) strengthened momentary work effort, via momentary intrinsic motivation, when chronic interactional justice was low (vs. high). This effect emerged for organizational and personal nostalgia. In Study 3, an experiment, we induced nostalgia and interactional justice. Induced nostalgia (vs. control) increased intrinsic motivation among participants experiencing low (vs. high) interactional justice. This effect of nostalgia was mediated by past-self directedness. In the face of low interactional justice, nostalgia makes employees experience their work as pleasant and motivating, leading them to exert more work effort.
Decomposition without aggregation for performance approximation in queueing network models of semiconductor manufacturing

Accurate and speedy forecasts of production cycle time are key components that support the operation of modern semiconductor wafer fabricators. Estimates of cycle time can be obtained via simulation, but such an approach, though common, requires significant computational investment and model maintenance. Queueing network models and approximations for their performance can provide a viable alternative. As modern semiconductor manufacturing systems exhibit largely reentrant product routing, but contain essential probabilistic routes (for metrology and rework), prior mean cycle time approximation methods are not well suited to the system structure. In this paper, we extend the decomposition without aggregation (DWOA) approach – which is tailored to systems with deterministic routing – to allow for the existence of probabilistic paths. Numerical and simulation studies are conducted with numerous practically inspired datasets to assess the quality of the resulting mean cycle time approximations. The results reveal that our approach outperforms the existing mean cycle time approximations on datasets inspired by the semiconductor industry MIMAC benchmark datasets. For example, in MIMAC dataset 1, our mean cycle time approximations exhibit an average of 10.33% error compared to 18.82% error for existing approaches.