Miracle-dz/UniFAR-FTUs huggingface dataset:
Multi-objective optimisation for heterogeneous cellular network planning

Small cell aims at improving the cell coverage and capacity of macrocell. Network operators investigate cell planning for improving system performance and for satisfying user requirements with minimal construction cost and least unserved users. Most of the existing literature merely considered a single objective function or investigated cell planning for small-scale and homogeneous networks. This study aims to optimise multiple objective functions of a large-scale and heterogeneous wireless network with multiple macrocells and multiple small cells. The authors formulate the multi-objective optimisation problem of cell planning for heterogeneous cellular networks. The three objects include construction cost, number of unserved users and network capacity. Then they propose the large-scale cell planning genetic algorithm (LSCPGA) to find a planning result with the lowest fitness value. Simulation results show that LSCPGA economises 9-20% construction cost, eliminates the number of unserved users from 4 to 10% and enhances 2-15% in network capacity compared to other planning algorithms.
Persuasive Electronic Word-of-Mouth Messages in Social Media

ABSTRACT Despite the influence of electronic word-of-mouth (eWOM) messages in decision-making processes, few studies have tested the determinants of persuasive eWOM messages among social media users. Although most of the researches focused on western and eastern cultural convergence or divergence of online communications, little attention has been paid on the validity and applicability of cultural orientations in countries with perceived inherent similar values. This study examines how Chinese and Malaysian users process eWOM messages and decide on continuing their overseas study. The significance of the study is to identify critical factors that influence Chinese and Malaysian users’ attitudes and behavior when processing persuasive eWOM messages. Results revealed that Facebook is the most used social networking site (SNS) for Malaysian users, while QQ Qzone for Chinese counterparts. This study found that argument quality, source credibility, source attractiveness, source perception, and source style exerted varying influences on Chinese and Malaysian users’ attitudes and intentions to continue their study abroad.
A rticle Origin and Differential Selection of Allelic Variation at TAS 2 R 16 Associated with Salicin Bitter Taste Sensitivity in Africa

Bitter taste perception influences human nutrition and health, and the genetic variation underlying this trait may play a role in disease susceptibility. To better understand the genetic architecture and patterns of phenotypic variability of bitter taste perception, we sequenced a 996 bp region, encompassing the coding exon of TAS2R16, a bitter taste receptor gene, in 595 individuals from 74 African populations and in 94 non-Africans from 11 populations. We also performed genotype–phenotype association analyses of threshold levels of sensitivity to salicin, a bitter anti-inflammatory compound, in 296 individuals from Central and East Africa. In addition, we characterized TAS2R16 mutants in vitro to investigate the effects of polymorphic loci identified at this locus on receptor function. Here, we report striking signatures of positive selection, including significant Fay and Wu’s H statistics predominantly in East Africa, indicating strong local adaptation and greater genetic structure among African populations than expected under neutrality. Furthermore, we observed a “star-like” phylogeny for haplotypes with the derived allele at polymorphic site 516 associated with increased bitter taste perception that is consistent with a model of selection for “high-sensitivity” variation. In contrast, haplotypes carrying the “low-sensitivity” ancestral allele at site 516 showed evidence of strong purifying selection. We also demonstrated, for the first time, the functional effect of nonsynonymous variation at site 516 on salicin phenotypic variance in vivo in diverse Africans and showed that most other nonsynonymous substitutions have weak or no effect on cell surface expression in vitro, suggesting that one main polymorphism at TAS2R16 influences salicin recognition. Additionally, we detected geographic differences in levels of bitter taste perception in Africa not previously reported and infer an East African origin for high salicin sensitivity in human populations.
Testing of CoAP Implementations and Applications through Fuzzing Techniques

The Constrained Application Protocol (CoAP) is an application-layer protocol standardized by the IETF in 2014. It follows the RESTful architectural style and aims for simplicity and low overhead, in order to be used as an enabler of the Internet of Things (IoT). Thus, even though it has features in common with HTTP, it is binary-encoded, runs over UDP etc. With the goal of studying and improving practical IoT software security, in this dissertation we design and implement a tool called FuzzCoAP. It is a system comprising a complete environment for testing robustness and security aspects of CoAP server-side implementations and applications. Five black-box fuzzing techniques were implemented in FuzzCoAP: Random, Informed Random, Mutational, Smart Mutational and Generational fuzzers. We use this tool to test a set of selected samples—CoAP applications running different implementations of the protocol. To select these samples, we conducted online searches looking for available CoAP implementations and related details, such as maturity status and popularity. We selected 25 samples (applications), covering 25 different CoAP libraries (implementations) distributed across 8 programming languages, including samples from IoT-specific operating systems RIOT OS and Contiki-NG. FuzzCoAP was able to detect a total of 100 errors in 14 out of the 25 tested samples. Experimental results show an average of 31.3% false positive rate and 87% error reproducibility when considering a “conservative error counting” and 1.9% false positive rate with 100% error reproducibility for an “optimistic” one. Fuzzing campaigns are executed in the order of minutes for most techniques (with an average of 45 minutes per campaign). The exception is the generational fuzzer, which attains an average of 12 hours per campaign, given it uses a considerably larger amount of test cases than the other techniques. We provide a discussion on how those five fuzzing techniques compare to each other in our scenario, and how robust (and secure) the CoAP implementations targeted are. Our data indicates the techniques are complementary to each other, corroborating with other studies suggesting that several techniques should be combined to achieve greater coverage and find more vulnerabilities. Finally, the entire research was conducted with an effort to be as open and reproducible as we could make it. Thus, both FuzzCoAP’s source-code as well as the collection of samples are freely available to the public. Likewise, to maximize the real-world impact on IoT security, all errors were reported to library maintainers. Some have already been fixed, while others are currently being handled, as of this text was written.
Correlation of NRF2 and progesterone receptor and its effects on ovarian cancer biology

Purpose This study aimed to investigate the potential prognostic impact of nuclear factor erythroid 2-related factor 2 (NRF2) and progesterone receptor A (PRA)/progesterone receptor B (PRB) in ovarian cancer patients which might be the rationale for putative new treatment strategies. Patients and methods The presence of NRF2 and PRA/PRB was investigated in 156 ovarian cancer samples using immunohistochemistry (IHC). Staining of NRF2 and PRA/PRB was rated using the semi-quantitative immunoreactive score (IR score, Remmele’s score) and correlated to clinical and pathological data. NRF2 and PRA/PRB expression were compared with respect to the overall survival (OS). Results NRF2 staining was different in both, the cytoplasm and nucleus between the histological subtypes (p=0.001 and p=0.02, respectively). There was a significant difference in the PRA expression comparing all histological subtypes (p=0.02). Histological subtypes showed no significant differences in the PRB expression. A strong correlation of cytoplasmic NRF2 and PRA expression was detected (cc=0.247, p=0.003) as well as of cytoplasmic NRF2 and PRB expression (cc=0.25, p=0.003), confirmed by immunofluorescence double staining. Cytoplasmic NRF2 expression was associated with a longer OS (median 50.6 vs 32.5 months; p=0.1) as it was seen for PRA expression (median 63.4 vs 33.1 months; p=0.08), although not statistically significant. In addition, high PRB expression (median 80.4 vs 32.5 months; p=0.04) and concurrent expression of cytoplasmic NRF2 and PRA were associated with a significantly longer OS (median 109.7 vs 30.6 months; p=0.02). The same relationship was also noted for NRF2 and PRB with improved OS for patients expressing both cytoplasmic NRF2 and PRB (median 153.5 vs 30.6 months; p=0.009). Silencing of NFE2L2 induced higher mRNA expression of PGR in the cancer cell line OVCAR3 (p>0.05) confirming genetic interactions of NRF2 and PR. Conclusion In this study, the combination of cytoplasmic NRF2 and high PRA/PRB expression was demonstrated to be associated with improved overall survival in ovarian cancer patients. Further understanding of interactions within the NRF2/AKR1C1/PR pathway could open new additional therapeutic approaches.
The Plasmodium falciparum protein VCAP1 controls Maurer’s cleft morphology, knob architecture and PfEMP1 trafficking

The malaria parasite, Plasmodium falciparum, traffics the virulence protein, P. falciparum erythrocyte membrane protein 1 (PfEMP1) to the surface of infected red blood cells (RBCs) via membranous organelles, known as the Maurer’s clefts. We developed a method for efficient enrichment of Maurer’s clefts and profiled the protein composition of this trafficking organelle. We identified 13 previously uncharacterised or poorly characterised Maurer’s cleft proteins. We generated transfectants expressing GFP-fusions of 7 proteins and confirmed their Maurer’s cleft location. Using co-immunoprecipitation and mass spectrometry we have generated a protein interaction map of proteins at the Maurer’s clefts. We identified two key clusters that may function in the loading and unloading of PfEMP1 into and out of the Maurer’s clefts. We focus on a putative PfEMP1 loading complex that includes the newly characterised virulence complex assembly protein 1 (VCAP1). Disruption of VCAP1 causes Maurer’s cleft fragmentation, aberrant knobs, ablation of PfEMP1 surface expression and loss of the PfEMP1 directed adhesion. ΔVCAP1 parasite lines have a growth advantage compared to wildtype parasites; and the infected RBCs are more deformable and more osmotically fragile. Importance The trafficking of the virulence antigen PfEMP1 and its presentation at the knob structures at the surface of parasite infected RBCs is central to severe adhesion related pathologies such as cerebral and placental malaria. This work adds to our understanding of how PfEMP1 is trafficked to the RBC membrane by defining the protein-protein interaction networks that function at the Maurer’s clefts controlling PfEMP1 loading and unloading. This work adds significantly to our understanding of virulence protein trafficking and will provide crucial knowledge that will be required to determine the mechanisms underpinning parasite driven host cell remodelling, parasite survival within the host and virulence mechanisms.
An Unsupervised Approach to Leak Detection and Location in Water Distribution Networks

Abstract The water loss detection and location problem has received great attention in recent years. In particular, data-driven methods have shown very promising results mainly because they can deal with uncertain data and the variability of models better than model-based methods. The main contribution of this work is an unsupervised approach to leak detection and location in water distribution networks. This approach is based on a zone division of the network, and it only requires data from a normal operation scenario of the pipe network. The proposition combines a periodic transformation and a data vector extension together with principal component analysis of leak detection. A reconstruction-based contribution index is used for determining the leak zone location. The Hanoi distribution network is employed as the case study for illustrating the feasibility of the proposal. Single leaks are emulated with varying outflow magnitudes at all nodes that represent less than 2.5% of the total demand of the network and between 3% and 25% of the node’s demand. All leaks can be detected within the time interval of a day, and the average classification rate obtained is 85.28% by using only data from three pressure sensors.
Unified and fast handover authentication based on link signatures in 5G SDN-based HetNet

Existing handover authentication schemes are implemented in the upper layer through cryptographic techniques with different protocols and parameters involved under different handover scenarios, introducing high latency and complexity especially in the next generation (5G) highly heterogeneous network (HetNet). The authors propose to introduce wireless link signatures decided by users' locations as handover authentication data to achieve unified and fast handover authentication at the physical layer in 5G software defined networking-based HetNet. Specifically, the unique wireless channel characteristics between a user and the serving access point (AP) are extracted as the secure context information (SCI) and transferred to the target AP. The latter determines whether the user is the legitimate one who has already been authenticated according to the received SCI. They then analyse the authentication performance relating to multiple attributes and results demonstrate that the authentication strength can be adaptively adjusted. Furthermore, they find that optimum performance can be achieved by setting a proper decision threshold and derive the sub-optimal performance by iterative search. Lastly, analysis and simulations on latency and overhead compared with existing ones are conducted and results prove the effectiveness of the proposed scheme.
Tailoring of PEGylated bilosomes for promoting the transdermal delivery of olmesartan medoxomil: in-vitro characterization, ex-vivo permeation and in-vivo assessment

Introduction The intention of this work was to load olmesartan medoxomil (OLM), a sparsely water soluble antihypertensive bioactive with low oral bioavailability (26%), into PEGylated bilosomes (PBs) for augmenting its transdermal delivery. PBs contain PEGylated single chain edge activator besides the components of traditional bilosomes (Span 60, cholesterol and bile salts). The PEG gives further resilience to vesicle membrane and is speculated to augment both permeability and bioavailability of OLM. Methods A 24 factorial experiment was constructed to inspect the impact of diverse variables on vesicles’ features and sort out the optimal formula adopting Design Expert® software utilizing thin film hydration technique. Vesicles’ evaluation was done by finding out entrapment efficiency percent (EE%), particle size (PS), polydispersity index (PDI), zeta potential (ZP) and amount of drug released after 6 hrs (Q6h). The optimal formula was selected and characterized for further investigations. Results The optimal formula (PB15) showed spherical vesicles with EE% of 72.49±0.38%, PS of 559.30±10.70 nm, PDI of 0.57±0.15, ZP of −38.35±0.65 mV and Q6h of 59.60±0.24%. PB15 showed higher deformability index (28.39±5.71 g) compared to traditional bilosomes (5.88±0.90 g) and transethosomes (14.94±0.63 g). Further, PB15 showed superior skin permeation from rat’s skin relative to the drug suspension. Moreover, confocal laser scanning microscopy examination revealed efficient penetration of the fluoro-labeled PB15 through skin. Histopathological study ensured the safety of PB15. In addition, in-vivo skin deposition studies showed higher OLM deposition in rat’s skin from PB15 compared to transethosomes and OLM suspension. Furthermore, pharmacodynamic and pharmacokinetic studies performed using male Wistar rats and male Albino rabbits, respectively, showed the superiority of PB15 over oral tablets. PB15 was found to have significantly higher AUC0–48 and AUC0–∞ relative to the oral tablets. As well, the relative bioavailability of PB15 was found to be 235.04%. Conclusion Overall, the obtained results confirmed the creditable effect of PB15 for transdermal delivery.
An Investigation into the Problem of Human Capital Burnout in the Public Service of Zimbabwe: A Case of Secondary School Teachers in Marondera District, Mashonaland East Province.

This study used both the qualitative and the quantitative research approaches in which the standardised Maslach Burnout Inventory (MBI) questionnaire was used to collect data from respondents to measure the dimensions and prevalence of burnout. A sample of eighty-eight secondary school teachers in MaronderaDistrict was used. This was followed by face-to-face interviews which targeted five secondary school heads. The findings of the study indicated that a significant number of teachers experienced different levels of burnout ranging from moderate to high burnout. The research showed that the socio-demographic factors as well as gender, marital status and age were associated with the nature and level of burnout which secondary school teachers succumb to unknowingly in their career. This caused symptoms such as fatigue, stress, emotional imbalance, desire to leave the job for greener pastures, loneliness and general lack of enthusiasm, dislike of the job, poor performance,fanned illnesses and absenteeism to be prevalent among affected teachers. The findings also showed that poor reward system, work overload, lack of resources, lack of recognition, lack of awareness on the appropriate burnout coping strategies, lack of stress management skills, poor motivation techniques, inappropriate leadership styles and unfavourable work environment were some of the drivers of burnout among teachers.The study recommended training of educational managers and leaders such as school heads, heads of departments, inspectorsand education officers about the implications of burnout, its signs and symptoms, control, management and eradication strategies. Use of ICTs in teaching to reduce work overload, recreational facilities in schools, reduction of teacher pupil ratios, improvement of conditions of service such as leaves and remuneration were also recommended. The study also recommended that authorities should engage in burnout policy formulation, implementation, monitoring and evaluation aimed at managing burnout as a way to rejuvenate the teaching profession where many teachers are suffering unknowingly to a level that students continue to benefit less.
Sistem Rekomendasi Komunitas Pemuda di Kota Semarang berbasis Item-based Collaborative Filtering dengan Metode Adjusted Cosine Similarity

Youth is national asset that will continue our development relay. But in reality, many of them spent their youth in vain to lapse drugs, or promiscuity. In the other side, youth community is one platform where youth can actively participate with the others to solve social problem. However, many of them still face difficulties to find contribution opportunity also clueless about which youth community that match them the most. To overcome that problem, we need a youth community recommendation system as an reference when they want to contribute through youth community which accordance to their preference. In this research, researcher will make a youth community recommendation system in Semarang so it can be used as reference for the youth in Semarang who want to contribute through youth community. Recommendation algorithm that will be used here is item-based collaborative filtering. These algorithm compute recommendation based on community similarity computing using adjusted cosine similarity method. The similarity value will computed from the value of user rating. From the recommendation test using 25 community data and 5 users, we can conclude that collaborative filtering algorithm can provide youth community recommendation which differ on each user in accordance to each rating given. Keyword : Recommendation system, youth community, collaborative filtering Generated by SiAdin Systems ï¿1⁄2 PSI UDINUS 2015
Inheritance pattern of genes for morpho-physiological and yield traits in wheat (Triticum aestivum L.)

In order to study the inheritance pattern of morpho-physiological traits in bread wheat, a 10×10 diallel cross, excluding reciprocals was made and grown in a randomized complete block design (RCBD) with three replications. Observations were recorded on Days to 75% flowering (DF), Days to maturity (DM), Duration of reproductive phase (DRP), Plant height (cm) (PH), Effective tiller/plant (TLS), No. of spikelets per spike (SLS), No. of grains per spike (GS), Grain weight per spike (g) (GW), Spike length (cm) (SL), Biological yield per plant (g) (BY), Harvest index (%) (HI), 1000-Grain weight (g) (TGW), Spike density (SD), Canopy temperature depression (°C) (CTD), Chlorophyll intensity (%) (CI), Chlorophyll fluorescence (Fv/Fm) (CF), Protein content (%) (PC), Grain yield per plant (g) (GY). Highly significant differences were observed among the genotypes for all traits. The resulted 45 F1s and their F2s used for study the nature of gene for grain yield and its contributing traits in bread wheat. The result indicated that considerable gene action and average degree of dominance respond to achieving significant result for grain yield and its component traits. In both the generations F1s and F2s, grain yield per plant (g) was governed by non-additive gene action based on combining ability analysis, (σ2 g/σ2 s)0.5 [GCA and SCA variance ratio] and (H1/D)0.5 [Degree of dominance] were exhibited over dominance type average degree of dominance for grain yield and its component traits in both generations. Genetic analyses of the traits confirm the involvement of both additive and non-additive gene effects in governing the inheritance.
Nest, egg, incubation behaviour and vocalisations of the New Guinea endemic Black Pitohui Melanorectes nigrescens

The Black Pitohui Melanorectes nigrescens (Pachycephalidae) is endemic to mid-mountain forests in mainland New Guinea. Spectrograms of three different songs recorded in the Yopno Urawa Som Conservation Area (YUS CA), Huon Peninsula, Papua New Guinea, are presented. We describe the elevation and nest-site, height above the ground, structure and materials of a nest with an egg, discovered in the YUS CA. The colour and dimensions of the egg are documented. We present photographs of the nest-site, nest, and egg, and compare these with previously described eggs and a nest. We observed only the female Black Pitohui incubating the single-egg clutch. We compare the meagre information on pitohui breeding biology with that of Australian whistlers and shrike-thrushes.