Miracle-dz/UniFAR-FTUs huggingface dataset:
Development and Aging on Motor Control Function with Precise Observations of Synchronization Hands’ Movements

— In advanced countries, populations are getting older. Cognitive disorder is a large problem in the countries. To understand the cognitive disorder with aging, we need to have a whole image of the development and the aging of our cognitive functions. We need to measure the performance of brain functions with the process of development and aging. For synchronizing with other motion, we need to feel the other motion, to recognize, to memorize, and to generate the synchronizing motion. We need many kinds of brain functions to make synchronizing movement. The authors proposed the cooperative visual synchronization task, its measuring method, implementation and experiments to measure and evaluate the performance of motor control function. The new task and the measuring method enable to measure the precise movements and evaluate the performance of motor control function easily in a short period. The proposed method is safe, because there is no need to attach the device to a subject nor to make exaggerated motions. This paper presents the results of experiments about primary school pupil, high-school students, young students, manhood people and elderly people. In addition, the authors show the overview of development and aging process of motor control function from objective measurement of cooperative movement in both hands.
AUDIO-TACTILE FEEDBACK IN MUSICAL GESTURE PRIMITIVES: FINGER PRESSING

We present a study on the effect of auditory and vibrotactile cues in a ﬁnger-pressing task. During a training phase subjects learned three target forces, and had to reproduce them during an experiment, under different feedback conditions. Results show that audio-tactile augmentation allowed subjects to achieve memorized target forces with improved accuracy. A tabletop device capable of recording normal force and displaying vibrotactile feedback was implemented to run several experiments. This study is ﬁrst in a series of planned investigations on the role of audio-haptic feedback and perception in relation to musical gestures primitives.
Development of Analog-Based Online Electronic Learning Models in Improving Students Learning Outcomes in Informatics Engineering Study Programs

– This study aims at developing an online based learning model in analogue electronics subjects. Respondents in this study were limited to students at STMIK Dipanegara Makassar who took analogue electronics courses. The research method used was research and development method which referred to Borg & Gall, Dick and Carry and Hannafin and Peck Models. To see the feasibility of the model that has been developed, researchers conducted expert tests, 1-1 tests, small group tests, and field trials in which the indicator is student learning outcomes of informatics engineering study programs. The results of this study indicate that this model is a potential design that is effective to be used during learning. It is proven by the increase of the completeness value of learning outcomes reached by the students. The average score of the learning outcome is 79.05 after using the learning model. The average score before using this learning model is only 55.05. Therefore, it can be concluded that the model developed has been effective in improving student learning outcomes in analogue electronics courses.
Rule-Based Recommender for Feature Engineering in Big Data

Feature engineering is of high importance for the success of many machine learning algorithms and requires domain-specific knowledge. Generally, this knowledge is only familiar to domain experts or incorporated into programs. We developed a knowledgedrive approach to support users during feature engineering and implemented a software application to evaluate this approach. The knowledge is represented in Web Ontology Language (OWL) and its main purpose is to offer the user a flexible way to tackle domain-specific datasets by building a reusable and comprehensible knowledge base. A semantic reasoner makes use of this knowledge to infer properties and provide users with recommendations. All data-related operations are performed in a scalable cluster computing engine backed up by Apache Spark. The evaluation is done on 6 freely available datasets from the domain of demographics. We were able to identify only a small fraction of recommendations that proved to be wrong.
I NFLUENCE OF PROCESS CONDITIONS ON REDUCTION OF SILICON AND CALCIUM IMPURITIES IN ALUMINUM SOLUTION

: As it is known, during regular conditions Bayer's process is used for production of alumina of a 99.0 % grade of purity. In order to obtain high-purity alumina which can then be used for special purposes, additional purification is performed in relation to the application of impurities, and, in the first hand removal of silica (Si) and calcium (Ca). One of the most effective ways of removing these compounds is the process of desilication. The method consists of treating an aluminate solution with lime that binds silica and calcium to tricalcium-aluminate (TCA) which is insoluble and therefore easily separated of the solution. The experimental research examined the impact of process parameters (temperature, time, concentration of added lime) on the efficacy of purifying aluminate solution from Si and Ca, which has a practical and theoretical contribution to aluminate solution research. Synthetic aluminate from non-metallurgic alumina and pure sodium-alkaline (NaOH) is used, in the caustic ratio in the range of 1.45-1.55. Classic volume analysis and analysis using optical emigration spectroscopy (ICP-OES) were used to determine the contents of aluminum and impurities. The experimental research found that short intervals are adverse because soluted compounds Ca(OH) 2 and tetra-calcium aluminum are formed. Also, during longer reaction time and higher temperatures there was an increase in the contents of Si and Ca in the aluminum, because some components from the limestone were dissolved. Small amounts of lime are adverse because there is an increase in calcium content in the solution since part of the lime dissolved, without interacting with the present impurities, while large quantities led to large aluminum loss due to the formation of TCA.
AN EPIDEMIOLOGICAL STUDY ON DEADLY DRUG (cid:487) DEFYING UNTREATABLE CARBAPENEM (cid:487) RESISTANT GRAM (cid:487) NEGATIVE BACTERIA ENCOUNTERED IN SOUTH INDIA

Objective: The rise of deadly “superbugs” among the pathogenic bacterial community is becoming a serious threat and the most centered concern in the field of clinical microbiology. The aim of this study was to investigate the epidemiological report on the current scenario of the multidrug- resistance (MDR) and extensive drug-resistance (XDR) characteristics of the frequent clinical isolates in South India. Methods: In this study, isolates were analyzed using standard microbiological techniques for a 3-month period (January 2013-March 2013). Antimicrobial susceptibility test in accordance with Clinical Laboratory Standards Institute guidelines (MICRO S23) 2013 were conducted. Resistant pattern analysis was done using penicillin, aminoglycosides, monobactam, cephalosporins, quinolones, carbapenems, tetracyclines, amphenicols, sulfonamides, and nitrofurantoin classes. Results: The highest frequency of MDR characters was owned equally by both the Escherichia coli and Klebsiella sp. with 29% resistance. However, Acinetobacter sp. , among the MDRs, though it contributed to only 6% prevalence, it exhibited 100% resistance toward carbapenems compared to all other organisms. Our study revealed that the prevalence of carbapenem-resistant Gram-negative bacteria (GNB) in South India is 21.42%. Conclusion: This study mainly underlines the increasing resistance in GNB to carbapenem with the data analysis over a 3-month period. This epidemiological report also insists on the dissemination of MDR among GNB in the South India. Hence, our team is working on the data for the similar period in the coming years also for having a strong hold on the status of MDR and XDR each year.
Uniﬁed Mathematical Formulation of Monogenic Phase Congruency

: Phase congruency is a technique that has been used for edge, corner and symmetry detection. Its implementation through the use of monogenic ﬁlters has improved its computational cost. For this purpose, different methods of implementation have been published, but they do not use a common notation, which makes it difﬁcult to understand. Therefore, this paper presents a uniﬁed mathematical formulation that allows a general understanding of the Monogenic phase congruency concepts and establishes criteria for its use. A new protocol for parameter tuning is also described, allowing better practical results to be obtained with this technique. Some examples are presented allowing one to observe the changes produced in the parameter tuning, evidencing the validity of the proposed criteria.
Auditory mismatch impairments are characterized by core neural dysfunctions in schizophrenia

Major theories on the neural basis of schizophrenic core symptoms highlight aberrant salience network activity (insula and anterior cingulate cortex), prefrontal hypoactivation, sensory processing deﬁcits as well as an impaired connectivity between temporal and prefrontal cortices. The mismatch negativity is a potential biomarker of schizophrenia and its reduction might be a consequence of each of these mechanisms. In contrast to the previous electroencephalographic studies, functional magnetic resonance imaging may disentangle the involved brain networks at high spatial resolution and determine contributions from localized brain responses and functional connectivity to the schizophrenic impairments. Twenty-four patients and 24 matched control subjects underwent functional magnetic resonance imaging during an optimized auditory mismatch task. Haemodynamic responses and functional connectivity were compared between groups. These data sets further entered a diagnostic classiﬁcation analysis to assess impairments on the individual patient level. In the control group, mismatch responses were detected in the auditory cortex, prefrontal cortex and the salience network (insula and anterior cingulate cortex). Furthermore, mismatch processing was associated with a deactivation of the visual system and the dorsal attention network indicating a shift of resources from the visual to the auditory domain. The patients exhibited reduced activation in all of the respective systems (right auditory cortex, prefrontal cortex, and the salience network) as well as reduced deactivation of the visual system and the dorsal attention network. Group differences were most prominent in the anterior cingulate cortex and adjacent prefrontal areas. The latter regions also exhibited a reduced functional connectivity with the auditory cortex in the patients. In the classiﬁcation analysis, haemodynamic responses yielded a maximal accuracy of 83% based on four features; functional connectivity data performed similarly or worse for up to about 10 features. However, connectivity data yielded a better performance when including more than 10 features yielding up to 90% accuracy. Among others, the most discriminating features represented functional connections between the auditory cortex and the anterior cingulate cortex as well as adjacent prefrontal areas. Auditory mismatch impairments incorporate major neural dysfunctions in schizophrenia. Our data suggest synergistic effects of sensory processing deﬁcits, aberrant salience attribution, prefrontal hypoactivation as well as a disrupted connectivity between temporal and prefrontal cortices. These deﬁcits are associated with subsequent disturbances in modality-speciﬁc resource allocation. Capturing different schizophrenic core dysfunctions, functional magnetic resonance imaging during this optimized mismatch paradigm reveals processing impairments on the individual patient level, rendering it a potential biomarker of schizophrenia.
Clinical Resistance to Enfuvirtide Does Not Affect Susceptibility of Human Immunodeﬁciency Virus Type 1 to Other Classes of Entry Inhibitors (cid:1)

The clinical use of the human immunodeﬁciency virus (HIV) fusion inhibitor enfuvirtide (ENF) can select for drug-resistant HIV-1 strains bearing mutations in the HR1 region of the viral envelope (Env) protein. We analyzed the properties of multiple Env proteins isolated from ﬁve patients who experienced an initial decline in viral load after ENF therapy followed by subsequent rebound due to emergence of ENF-resistant HIV-1. Prior to ENF therapy, each patient harbored genetically and phenotypically diverse Env proteins that used CCR5 and/or CXCR4 to elicit membrane fusion. Coreceptor usage patterns of the Envs isolated from two patients underwent homogenization following ENF therapy, whereas in the other three patients, recombination appeared to allow the introduction of a single HR1 sequence with ENF resistance mutations into phenotypically distinct Env proteins. Analysis of individual Env clones also revealed that prior to ENF therapy, there was sometimes marked heterogeneity in the susceptibility of individual Env proteins to coreceptor inhibitors. After virologic failure, all Envs acquired resistance to ENF but exhibited no consistent change in their sensitivity to the fusion inhibitor T-1249 or to coreceptor inhibitors. In summary, using patient-derived Env proteins, we found that ENF failure was associated with emergence of high-level resistance to ENF enfuvirtide therapy. All ﬁve patients in study experienced a temporary, though signif-icant, decline in viral load (VL) following ENF therapy, followed by a full rebound presumably owing to the emergence of ENF-resistant virus. Viral load was determined using a branched DNA assay as described previously.
A Simple Clinical Classi cation System for Early De nitive Treatment Improves Quality of Care in Acute Biliary Pancreatitis

Shengjie Dai wenzhou medical collage Hongru Kong Wenzhou Medical College First A liated Hospital: The First A liated Hospital of Wenzhou Medical University Meng Wang Wenzhou Medical College First A liated Hospital: The First A liated Hospital of Wenzhou Medical University Zhe Chen Wenzhou Medical College First A liated Hospital: The First A liated Hospital of Wenzhou Medical University Huajun Yu Wenzhou Medical College First A liated Hospital: The First A liated Hospital of Wenzhou Medical University Yuepeng Jin Wenzhou Medical College First A liated Hospital: The First A liated Hospital of Wenzhou Medical University Yunfeng Shan Wenzhou medical collage Keqing Shi wenzhou medical collage Hong-Wei Sun (  sunhongwei1@163.com ) The First A liated Hospital of Wenzhou Medical University https://orcid.org/0000-0001-5700-8247
A Strategy for Veriﬁcation of Weather Element Forecasts from an Ensemble Prediction System

Using a Bayesian context, new measures of accuracy and skill are proposed to verify weather element forecasts from ensemble prediction systems (EPSs) with respect to individual observations. The new scores are in the form of probabilities of occurrence of the observation given the EPS distribution and can be applied to individual point forecasts or summarized over a sample of forecasts. It is suggested that theoretical distributions be ﬁt to the ensemble, assuming a shape similar to the shape of the climatological distribution of the forecast weather element. The suggested accuracy score is simply the probability of occurrence of the observation given the ﬁtted distribution, and the skill score follows the standard format for comparison of the accuracy of the ensemble forecast with the accuracy of an unskilled forecast such as climatology. These two scores are sensitive to the location and spread of the ensemble distribution with respect to the verifying observation. The new scores are illustrated using the output of the European Centre for Medium-Range Weather Forecasts EPS. Tests were carried out on 108 ensemble forecasts of 2-m temperature, precipitation amount, and windspeed, interpolated to 23 Canadian stations. Results indicate that the scores are especially sensitive to location of the ensemble distribution with respect to the observation; even relatively modest errors cause a score value signif- icantly below the maximum possible score of 1.0. Nevertheless, forecasts were found that achieved the perfect score. The results of a single application of the scoring system to veriﬁcation of ensembles of 500-mb heights suggests considerable potential of the score for assessment of the synoptic behavior of upper-air ensemble forecasts.Thepaper concludes with a discussion of the new scoring method in the more general context of veriﬁcation of probability distributions.
Development and Evaluation of a Flocked Nasal Midturbinate Swab for Self-Collection in Respiratory Virus Infection Diagnostic Testing (cid:1)

We developed and evaluated ﬂocked nasal midturbinate swabs obtained from 55 asymptomatic and 108 symptomatic volunteers. Self-collected swabs obtained from asymptomatic volunteers yielded numbers of respiratory epithelial cells comparable to those of staff-collected nasal ( n (cid:1) 55) or nasopharyngeal ( n (cid:1) 20) swabs. Speciﬁc viruses were detected in swabs self-collected by 42/108 (38.9%) symptomatic volunteers by multiplex PCR. We report herein the design and evaluation of a novel self-collected nasal midturbinate swab for respiratory virus diagnosis. We previously demonstrated that Copan ﬂocked nasopharyngeal swabs (NPS) collected signiﬁcantly more respiratory epithelial cells than conventional rayon swabs and improved sample collection for
Austin Neurosurgery: Open Access The Medial Cord –Anterior Upper Trunk (MC-aUT) Nerve Transfer in Brachial Plexus Injuries. Technique and Results

Aim of this paper is to report on a technical variant of the Medial Cord to the Musculocutaneous (MCMc) nerve transfer. The MCMc is a new type of neurotization that we described in 2014, capable of reanimating the elbow flexion in multilevel avulsive injuries of the upper and middle plexus. In the over mentioned procedure the reinnervation of the musculocutaneous nerve is obtained via a nerve transfer from the medial cord. The selected fascicles are those directed principally to the flexor carpi radial is, ulnaris, and to a lesser degree the flexor digitorum profundus. They are located in the inverted V-shaped bifurcation between the internal contribution of the median nerve and the ulnar nerve. The results of this technique are excellent. There are no failures and no complications when the hand shows a normal wrist and finger flexion and a normal intrinsic function, namely in C5-C6 or C5-C6-C7 avulsive injuries of the brachial plexus. However, the sole problem appears with an agenesia of the musculocutaneous nerve (4% of our series). In these patients, the lateral cord tapers directly into the median nerve one or more branches entering directly the biceps and the brachialis muscles at the upper third of the arm. This arrangement is hostile to the MCMc nerve transfer so as it was originally conceived. The present paper reports the results of a technical variant of the MCMc technique, namely the targeting, as recipient, of the anterior contribution of the upper trunk, cut and rerouted under the clavicle to reach the donor medial cord.
Birmingham The use of natural antioxidants to combat lipid oxidation in O/W emulsions

This research investigated the efficacy of four natural antioxidants, quercetin, curcumin, rutin 19 hydrate and ascorbic acid in their ability to combat Lipid Oxidation (LO) within different oil-in- 20 water (O/W) emulsion environments. The free radical scavenging and metal chelating ability 21 of the four antioxidants was first assessed through DPPH and Ferrozine assays respectively 22 and used to help explain each antioxidants efficacy in particular environments. Generally, in 23 emulsions with no added iron, compounds that exhibited the greatest levels of DPPH and 24 Ferrozine inhibition provided the best oxidative stability. In the presence of added iron, 25 antioxidant effectiveness reduced dramatically and in some cases resulted in prooxidant 26 activity. It was concluded that the antioxidant metal chelating mechanism of antioxidants in 27 emulsions with added iron was largely insignificant compared to the prooxidant effect gained 28 by these compounds through their interaction with iron. The most non-polar compounds, 29 curcumin and quercetin provided peroxide value (PV) reductions of 65% and 74% 30 respectively in 5% oil phase volume emulsions compared to just 28% and 43% PV 31 reductions in 40% oil phase volume emulsions; thus providing more evidence of the widely 32 reported ‘polar paradox’. Combinations of ascorbic acid with quercetin or curcumin resulted 33 in antioxidant synergism, whereas other antioxidant combinations led only to additive or 34 antagonistic effects. This research builds on the understanding of the fundamental behaviour 35 of natural antioxidants within different emulsion formulations.
VMRR_A_319761 205..215

University of Gondar, College of Veterinary Medicine and Animal Sciences, Para-Clinical Studies, Gondar, Ethiopia Abstract: Foot and mouth disease (FMD) is an extremely contagious viral disease of livestock caused by foot and mouse disease virus genus: Aphthovirus, which causes a serious economic impact on both individual farmers and the national economy. Many attempts to advance a vaccine for FMD have failed to induce sterile immunity. The classical methods of vaccine production were due to selective accumulation of mutations around antigenic and binding sites. Reversion of the agent by positive selection and quasi-species swarm, use of this method is inapplicable for use in non-endemic areas. Chemical attenuation using binary ethyleneimine (BEI) protected the capsid integrity and produced a pronounced immunity against the challenge strain. Viral antigens which have been chemically synthesized or expressed in viruses, plasmid, or plants were tried in the vaccination of animals. DNA vaccines expressing either structural or nonstructural protein antigens have been tried to immunize animals. Using interleukins as a genetic adjuvant for DNA vaccines have a promising effect. While the challenges of inducing sterile immunity lies on nonstructural (NS) proteins of FMDV which are responsible for apoptosis of dendritic cells and have negative effects on lympho-proliferative responses which lead to transient immunosuppression. Furthermore, destruction of host protein trafficking by nonstructural proteins suppressed CD8 T-cell proliferation. In this review, it tried to address multiple approaches for vaccine development trials and bottle necks of producing sterile immunity.