Miracle-dz/UniFAR-FTUs huggingface dataset:
Activation of the Immune-Inflammatory Response System and the Compensatory Immune-Regulatory Reflex System in Antipsychotic Naive First Episode Psychosis

Background: First episode psychosis (FEP), schizophrenia and affective disorders are accompanied by activation of the immune inflammatory response system (IRS). The compensatory immune-regulatory reflex system (CIRS) is a regulatory immune response that is induced by the IRS but exerts negative feedback through, for example, increased levels of anti-inflammatory cytokines such as IL-4, IL-13 and IL-10. Different phenotypes of schizophrenia may exhibit distinct IRS and CIRS immune profiles.Aims: This study aims to examine the IRS and CIRS components, including macrophagic M1, T-helper (Th)-1, Th-2, Th-17 and T-regulatory (Treg) phenotypes, in antipsychotic-naïve FEP patients before and after risperidone treatment.Methods: We included 31 antipsychotic-naïve FEP patients who had measurements of IRS and CIRS biomarkers before and after treatment with risperidone for 10 weeks, and 22 healthy controls.Results: Antipsychotic-naive FEP patients showed interrelated increments in M1, Th-1, Th-2, Th-17 and Treg phenotypes and a relatively greater IRS response (especially granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-6 and IL-12) as compared with the CIRS response (IL-4, IL-13, IL-5 and IL-10). Inflammatory markers, especially IL-6 and IL-8, were significantly correlated with negative, psychotic, affective and excitation symptom dimensions. Treatment with risperidone significantly suppressed the IRS and CIRS. Baseline levels of CIRS biomarkers, especially higher soluble tumor necrosis factor receptor-1 and IL-10 predicted clinical improvement during treatment.Discussion: Our findings indicate that FEP is characterized by robust IRS (M1 + Th-1 + Th-17) and CIRS responses, suggesting that monocytes, macrophages, Th-1, Th-2, Th-17 and Treg cells are activated. The findings indicate that a) FEP patients are prone to the detrimental effects of M1, Th-1, Th-17 and Th-2 cells, which may contribute to long-lasting abnormalities in brain circuitry; and b) in FEP, the CIRS may contribute to recovery from the acute phase of illness. Enhancing the CIRS is a new drug target to treat FEP.
Pellet Feed Improvements through Vitamin C Supplementation for Snakehead, Channa striata (Bloch 1793), Culture

Vitamin C, or ascorbic acid (AA), is important in growth and physiological functions of fish. Six soybean meal-based (SBM) diets containing 0, 125, 250, 500, 1000 and 2000 mg.kg -1 of AA were fed to snakehead, Channa striata (Bloch 1793) (initial weight 6.63 + 0.16 g) for 8 weeks in the laboratory. Survival of snakehead in the 250 and 500 mg.kg -1 treatments was significantly higher ( P < 0.05) than the control, but not in the other treatments. Final weight and specific growth rate (SGR) of fish in all the AA-supplemented diet treatments were significantly higher ( P < 0.05) than the control. Feed intake (FI), feed conversion ratio (FCR), and protein efficiency ratio (PER) also differed significantly, but not in a clearly dose-dependent manner. The requirement of AA for snakehead was calculated to be 277 mg.kg -1 . No vertebral anomalies were observed. Erythrocyte count was significantly ( P < 0.05) higher at 1000 and 2000 mg.kg -1 than at 0 and 125 mg.kg -1 . Fish in 250 mg.kg -1 had significantly ( P < 0.05) higher leukocyte count than those in 0, 1000, and 2000 mg.kg -1 . A bacterial challenge test with Aeromonas hydrophila revealed that 500 and 1000 mg.kg -1 had the lowest cumulative mortality. In an on-farm trial, SBM-based and commercial diets augmented with 0, 500, 750, or 1000 mg.kg -1 AA were fed to C. striata for 23 weeks. All AA-supplemented SBM-based diets provided significantly ( P < 0.05) higher final weights and overall yield than did all the AA-supplemented commercial diets. Maximum survival (85.3 %), final fish weight (573.5 g), yield (293.3 kg.hapa -1 ) and profit (0.38 USD.kg fish -1 ), as well as minimum FCR (1.16), production cost (1.12 USD.kg fish -1 ) and feed cost (0.98 USD.kg fish -1 ) were obtained with the 500 mg.kg -1 SBM diet
Natasha

Oh darlink, oh darlink, won’t you give up moose and squirrel business? I am in kitchen sharpenink knives, I am in bedroom sharpenink myself, but you sit on couch, you watch on TV moose pull America out of hat, recite I wandered lonely as cloud. Daffodils I do not want, my darlink. I want to be nogoodnik with you, and you alone. Squirrel sounds like MiG plane but laughs like Boy Scout, and every time, it is your face bomb explodes in, you and I left holdink bag. Won’t you come outside, see cloud that looks like anvil going to drop on neighbors? I have recipe for happiness, and it is this: forget blueprints, rubber masks, bombs like great, black cherries. Forget even Fearless Leader and his dusty monocle. Let us go, let us take walk and I will show you all of dead baby birds left behind in nests, show you prisons, tent cities, oil slicks big as heartland. Just give me chance, my darlink, and I will show you sometink you will really like.
Integrated Design of Smart Campus Operation and Maintenance Management System Based on BIM in Big Data Environment

: Smart campus comprehensively uses technologies such as mobile internet and big data to integrate, analyze and share all kinds of data in universities. The campus building is a place that needs to carry history and reflect the characteristics of the times. With the continuation of historical time and the change of management personnel, there may be breakpoints in campus operation and maintenance management, such as the mismatch between the completed drawings and the actual construction, the unclear level of underground pipeline network, the inability to accurately determine the cause and source of accidents, and the lack of obvious effectiveness of space management. To solve the problems existing in traditional campus operation and maintenance management and improve management efficiency, this paper proposes an integrated design of intelligent campus operation and maintenance management system based on BIM. Reverse application of BIM technology, review and import the completed campus project information, get rid of BIM's thinking inertia of forward planning, design, construction and maintenance, find out the errors between the construction drawings and the actual completion, revise and improve the as-built drawings, and ensure the accuracy of normal campus operation and maintenance.
The Effects of the Korean Medicine Health Care Program on Stroke-Related Factors and Self-Care Enhancement

Objectives This study was performed to examine the effects of the Korean medicine healthcare program on stroke-related factors and self-care enhancement. Methods This study was a quasi-experimental, pretest-posttest nonequivalent control group design study (N = 58 participants), with 28 in the treatment group (Korean medicine health care program) and 30 in the control group (no intervention). The program was conducted twice a week for 2 hours, for a total of 12 weeks. Results There were statistically significant differences in systolic (p = 0.005) and diastolic blood pressure (p = 0.006), cholesterol (p < 0.001), blood glucose (p < 0.001), self-esteem (p = 0.001), self-efficacy (p < 0.001), health perception (p < 0.001), and the health behavior (p < 0.001) between the experimental group and the control group. Conclusion Thus, the Korean medicine healthcare program was effective in managing stroke-related factors and enhancing self-care, and should be actively used to develop community health promotion strategies to prevent strokes and prepare long-term measures.
A Kinematic Evaluation of Linear and Parabolic Pointing in Virtual Reality

We present the results of a study investigating the influence of task and effector constraints on the kinematics of pointing movements performed in immersive virtual environments. We compared the effect of target width, as a task constraint, to the effect of movement distance, as an effector constraint, in terms of overall effect on movement time in a pointing task. We also compared a linear ray-cast pointing technique to a parabolic pointing technique to understand how interaction style may be understood in the context of task and effector constraints. The effect of target width as an information constraint on pointing performance was amplified in VR. Pointing technique acted as an effector constraint, with linear ray-cast pointing resulting in faster performance than parabolic pointers.
Multilingual Multi-Domain NMT for Indian Languages

India is known as the land of many tongues and dialects. Neural machine translation (NMT) is the current state-of-the-art approach for machine translation (MT) but performs better only with large datasets which Indian languages usually lack, making this approach infeasible. So, in this paper, we address the problem of data scarcity by efficiently training multilingual and multilingual multi domain NMT systems involving languages of the 𝐈𝐧𝐝𝐢𝐚𝐧 𝐬𝐮𝐛𝐜𝐨𝐧𝐭𝐢𝐧𝐞𝐧𝐭. We are proposing the technique for using the joint domain and language tags in a multilingual setup. We draw three major conclusions from our experiments: (i) Training a multilingual system via exploiting lexical similarity based on language family helps in achieving an overall average improvement of 𝟑. 𝟐𝟓 𝐁𝐋𝐄𝐔 𝐩𝐨𝐢𝐧𝐭𝐬 over bilingual baselines, (ii) Technique of incorporating domain information into the language tokens helps multilingual multi-domain system in getting a significant average improvement of 𝟔 𝐁𝐋𝐄𝐔 𝐩𝐨𝐢𝐧𝐭𝐬 over the baselines, (iii) Multistage fine-tuning further helps in getting an improvement of 𝟏-𝟏. 𝟓 𝐁𝐋𝐄𝐔 𝐩𝐨𝐢𝐧𝐭𝐬 for the language pair of interest.
Anxiety-impulsivity subtypes in adolescent internalizing disorder are characterized by distinguishable neurodevelopmental, neurocognitive and clinical trajectory signatures

Background Anxiety and impulsivity represent transdiagnostic pathology dimensions yet their interaction and contribution to emotional disorders in adolescence and to disease development remain controversial, and previous studies indicate heterogeneity within the broad category of internalizing disorders. Methods A combination of hierarchical and non-hierarchical clustering strategies was employed to determine impulsivity-related subtypes (based on the facets of negative urgency, lack of planning, lack of perseverance, sensation seeking and positive urgency in UPPS-P scales) in a large cohort of adolescents with internalizing disorders (n=2437) from Adolescent Brain Cognitive Development (ABCD) Study. Linear mixed-effect models were employed to determine cortical thickness alterations of the subtypes. Results Data-driven clustering identified two distinct subtypes of internalizing patients (subtype 1/subtype 2) with comparable levels of increased anxiety yet distinguishable levels of impulsivity, i.e., enhanced (subtype 1) or decreased (subtype 2) compared to healthy controls. Subtype 1 was further characterized by thicker prefrontal and temporal cortical regions involved in regulatory control and fear processing, while subtype 2 did not demonstrate significant thickness alterations. The differential neuroanatomical profiles remained stable over the two-year follow-up, while the two subtypes had different neurodevelopmental trajectories. Subtype 1 additionally reported more psychopathology and dysfunctionality including higher suicidal ideation, depressive symptoms and transition rates to externalizing disorders during follow-up as well as impaired neurocognitive and educational performance compared to subtype 2. Moreover, for subtype 1, anxiety at baseline (9-10 years) was significantly positively associated with impulsivity (lack of perseverance) at 2-year follow-up, while in subtype 2, baseline anxiety was significantly negatively associated with impulsivity (sensation seeking) at 2-year follow-up. Conclusions Our results demonstrate an impulsivity-dependent heterogeneity in adolescent internalizing disorders, with high-impulsivity patients being characterized by neurodevelopmental delay at the neural and cognitive levels. Individuals with elevated impulsivity are at a greater risk to develop behavioral dysregulation over the following two years and may thus require specific early interventions.
An assessment of water footprint for irrigated rice in Punjab

Water scarcity has become one of the highest risks for environmental and economic security worldwide. The water footprint for rice production, i.e., the total volume of freshwater consumed to produce a unit quantity rice has been estimated for three different agroclimatic zones of Punjab for the years 2000 to 2017. The results revealed that effective rainfall (Peff) improved in later years due to a change in crop calendar,legally enforced by an Act prohibiting the transplanting of paddy before a specified date. During the period of study, minimum crop evapotranspiration (ET c) was 4645 and maximum was ETc of 9511 m3ha -1 during 2014 and 2011, respectively. The green water footprint (W F green) for rice varied from 646litreskg -1of rice during low rainfall years (2012) to 1149 litre kg -1 of rice during heavy rainfall (1192 mm) during 2011.Out of a total water footprint (WF total) of 2650 litre kg -1, the share of blue water footprint (WFblue) was higher 1804 litre kg -1 (68%), indicating a need to improve on-farm irrigation management to conserve water resources.
Clinical, histopathological, and molecular characterization of Mycoplasma species in sheep and goats in Egypt

Abstract Background and Aim: Mycoplasma infection in small ruminants is a serious problem in sheep and goat herds around the world. It is responsible for high economic losses and decreased animal productivity. This study aimed to highlight the clinical, histopathological, minimum inhibitory concentration (MIC), and molecular characterization of Mycoplasma species in sheep and goats in Menoufiya Governorate, Egypt. Materials and Methods: A total of 234 samples were collected; 104 samples were collected from pneumonic lung tissues from the abattoir, in addition, 10 and 20 samples collected from apparently and diseased sheep, respectively, and 40 and 60 samples were collected from apparently and diseased goats, respectively, which were subjected to isolation onto pleuropneumonia-like organism medium. Polymerase chain reaction (PCR), histopathological examination, and determination of the MIC were also performed. Results: Of 104 samples of lung tissues showing pneumonic lesions, 56 (53.84%) were positive for Mycoplasma isolation. The positive isolation of Mycoplasma from 10 and 20 samples from apparently and diseased sheep was 30% and 40%, respectively as well as the positive isolation of Mycoplasma was 17% and 56.66% out of 40 and 60 apparently healthy and diseased field goat’s cases, respectively. All the diseased sheep and goats showed respiratory manifestations, including cough, bilateral nasal discharge, conjunctivitis, and systemic reaction. Evaluation of the MIC for Mycoplasma ovipneumoniae revealed that lincospectin and tylosin were the most effective antibiotics at 2.5 mg/mL. Histopathological examination of affected lung tissue showed extensive hemorrhagic pneumonia with extensive alveolar hemorrhage. The PCR technique proved to be a rapid, specific, and sensitive method for the detection of M. ovipneumoniae and Mycoplasma arginini at 390 and 326 bp, respectively. Conclusion: M. ovipneumoniae and M. arginini were the most prevalent species associated with respiratory infections in sheep and goats in the study area. Further studies are needed to investigate the role of these species in dissemination of the disease within herds of small ruminants.
Rapid Calorimetric Detection of Bacterial Contamination: Influence of the Cultivation Technique

Modern isothermal microcalorimeters (IMC) are able to detect the metabolic heat of bacteria with an accuracy sufficient to recognize even the smallest traces of bacterial contamination of water, food, and medical samples. The modern IMC techniques are often superior to conventional detection methods in terms of the detection time, reliability, labor, and technical effort. What is missing is a systematic analysis of the influence of the cultivation conditions on calorimetric detection. For the acceptance of IMC techniques, it is advantageous if already standardized cultivation techniques can be combined with calorimetry. Here we performed such a systematic analysis using Lactobacillus plantarum as a model bacterium. Independent of the cultivation techniques, IMC detections were much faster for high bacterial concentrations (>102 CFU⋅mL–1) than visual detections. At low bacterial concentrations (<102 CFU⋅mL–1), detection times were approximately the same. Our data demonstrate that all kinds of traditional cultivation techniques like growth on agar (GOA) or in agar (GIA), in liquid media (GL) or on agar after enrichment via membrane filtration (GF) can be combined with IMC. The order of the detection times was GF < GIA ≈ GL ≈ GOA. The observed linear relationship between the calorimetric detection times and the initial bacterial concentrations can be used to quantify the bacterial contamination. Further investigations regarding the correlation between the filling level (in mm) of the calorimetric vessel and the specific maximum heat flow (in μW⋅g–1) illustrated two completely different results for liquid and solid media. Due to the better availability of substrates and the homogeneous distribution of bacteria growing in a liquid medium, the volume-related maximum heat flow was independent on the filling level of the calorimetric vessels. However, in a solid medium, the volume-related maximum heat flow approached a threshold and achieved a maximum at low filling levels. This fundamentally different behavior can be explained by the spatial limitation of the growth of bacterial colonies and the reduced substrate supply due to diffusion.
PHYTOCHEMICAL STUDIES ON GROWTH, YIELD AND CHEMICAL CONSTITUENTS OF FENNEL PLANTS (Foeniculum vulgare Mill) AS EFFECTED BY ANTIOXIDANTS SUBSTANCES

In pot experiment were carried out in the Experimental farm, Faculty of Agriculture, Fayoum University, during two successive seasons of 2006/2007 and 2007/2008 to investigate the effect antioxidants, namely, ascorbic acid, citric acid and vitamin B each alone, at the rates of, 100, 250 and 500 ppm on improving the growth, yield and some chemical constituents of fennel plants grown under saline reclaimed soil conditions. The obtained results showed that the treated fennel plants with ascorbic acid, citric acid and vitamin B reduced the harmful effect of soil salinity and improved plant growth characters expressed as plant height, number of branches, fresh and dry weights of herb plant -1 , number of umbels plant -1 , diameter of umbel, fresh and dry weights of umbels plant -1 and weight of seeds plant -1 , as well as, yield of essential oil, total chlorophylls and carotenoids content, total carbohydrate and N percentage. Generally, the highest rate of antioxidants substances (500 ppm) gave the best results on the above characters which studied and were arranged as vitamin B followed by ascorbic acid then citric acid.
Mobile Internet Access and Desire to Migrate∗†

How does internet access affect migration intentions and behavior? To answer to this question, we combine a unique survey data set from 120 countries comprising more than 600,000 individuals with data on worldwide 3G mobile internet roll-out spanning from 2008 to 2018. We find a positive effect on plans to migrate (both in general and internationally) within 12 months and the preparation to migrate. We furthermore argue that pre-trends in migration intentions prior to expansion of 3G networks are unlikely to be present. Importantly, no statistically significant effects of 2G coverage have been found, excluding communication as a possible mechanism, allowing for internet access and use-related explanations.
Proceedings of the Annual Meeting of the Cognitive Science Society

Recently, there has been research on what factors inﬂuence a user’s password setting practices, which include various types of emotions such as anger, risk-taking tendencies, etc. However, research has shown that factors such as memorability and perceived memorability have a greater inﬂuence on password choice. Some recent research has shown a negative correlation between the perceived memorability and the perceived security of passwords, particularly passphrases (that are technically more secure). However, it is unclear whether this effect can be extended to groups with good experiences with digital spaces (IT professionals, entrepreneurs, etc.). Furthermore, it has not been determined whether random, uncommonly-worded, or complex structure passphrases would also maintain the correlation, as opposed to relatively less secure, common/simple passphrases. This study examines this problem using a diverse demographic and different categories of passphrases.
Simplified Human Computer Interface Design Using EEG Signals

Brain Computer Interfaces (BCI) are applications that allow users to communicate and control external devices directly by analyzing changes in brain activity without using muscle and nerve cells, which are normal pathways of the brain. It can also be said that BCIs are an alternative means of communication between the human brain and the outside world based on the electrical activities of brain activity, which can be measured by electroencephalography (EEG) devices. In the EEG measured from the human brain, when a person wants to move a limb, the potentials associated with the event are observed in the EEG. This suggests that information about changes in the activity of the human brain in the cognitive or movement decision process can be detected in the observed EEG.In this study, the attributes of the signals obtained using a four-channel EEG recorder are extracted and classified. Because the experimental study was performed while the user was awake, it processed beta signals. Considering the artifacts, the processed data was used as input data for the interface by realizing
On Using the Ridge Regression to solve the Multi-collinearity Problem

Original Research Article Multicollinearity is a phenomenon when two or more predictors are highly correlated that leading the matrix to be singular, and hence identifying the least squares estimates will encounter numerical problems. In this work, we proposed two remedial measures for handling severe multicollinearity in the least-squares estimation, namely, the Ridge regression, and Least Absolute Shrinkage and Selection Operator (Lasso). A simulation study was conducted to compare the two proposed methods under different settings. These settings include different sample sizes, a variety of several explanatory variables used in the model along with the difference in the degree of correlation that exists among the explanatory variables, and finally the dependency of the error terms on the normal or non-normal distributions. This simulation study is novel in the field of Shrinkage Estimators, also may increase the effective capabilities of Ridge Regression, and several interesting results have been achieved.
A Hedonic Pricing Approach to Value Ecosystem Services Provided by Water Sensitive Urban Design: Comparison of Geelong, Australia and Singapore

Water Sensitive Urban Design (WSUD) features are increasingly used for urban water management, green urban design, and improved community liveability, but relatively less data are available on the ecosystem services that WSUD provides. We used hedonic pricing, supported by qualitative surveys, in Geelong, Australia and Singapore, to evaluate benefits related to large WSUD features. For both locations there was a significant (α=0.05) inverse relationship between the sales price of a residence and distance to the WSUD features. Qualitative surveys corroborated the hedonic pricing analysis, as a majority of people appreciated benefits accrued from living near WSUD features.