Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring Automatic Citation Classification

Currently, citation indexes used by digital libraries are very limited. They only provide raw citation counts and link scientific articles through their citations. There are more than one type of citations, but citation indexes treat all citations equally. One way to improve citation indexes is to determine the types of citations in scientific articles (background, support, perfunctory reference, etc.) This will enable researchers to query citation indexes more efficiently by locating articles grouped by citation types. For example, it can enable a researcher to locate all background material needed to understand a specific article by locating all “background” citations. Many classification schemes currently exist. However, manual annotation of all existing digital documents is infeasible because of the sheer magnitude of the digital content, which brings about the need for automating the annotating process, but not much research has been done in the area. One of the reasons preventing researchers from researching automated citation classification is the lack on annotated corpora that they can use. This thesis explores automated citation classification. We make several contributions to the field of citation classification. We present a new citation scheme that is easier to work with than most. Also, we present a document acquisition and citation annotation tool that helps with the development of annotated citation corpora. And finally, we present some experiments with automating citation classification.
Developing Computational Thinking Skills in Adolescents With Autism Spectrum Disorder Through Digital Game Programming

In the last years, many didactic activities have been proposed to develop Computational Thinking (CT) skills in children and adolescents. Among these activities, the digital game programming stands out as a promising alternative considering that it is related to a familiar and motivating context for students. These initiatives are not specifically aimed at individuals with special needs such as the autism spectrum disorder (ASD). Children and adolescents with ASD usually have some limitations related to communication, cognitive flexibility, and interpersonal relationships. However, it seems natural that the skills potentially developed through game programming activities are especially beneficial for the public with ASD. In this paper, we describe the offering and evaluation of a Game Building Workshop adapted to adolescents with this condition. The guidelines used to define the workshop activities are described. An assessment based on the classroom observation and analysis of produced artifacts indicate that the participants acquired CT skills related to programming at a high level. In addition, the collaborative nature of the activities offered a stimulating and welcoming environment for individuals with ASD.
An Advanced Driver Risk Measurement System for Usage-Based Insurance on Big Driving Data

Usage-based-insurance is an emerging automobile insurance service in which the driver premium is set individually for each policyholder. A personalized automobile insurance mechanism presents challenges that differ from those presented by the general driver assistance applications that analyze driver behaviors. In this paper, a novel framework based on boosted multiple-kernel learning is proposed to reflect the driving risk level of each driver for automobile usage-based-insurance. In the proposed framework, a set of kernels is specified to represent the inherent characteristics of vehicle-oriented, driver-oriented, and lane-oriented attributes. These multiple kernels are carefully integrated using the AdaBoost technique to realize particular collaborative features for driving risk assessment. Experimental results obtained using a lab-recorded driving data set under real-world conditions reveal that the proposed framework exhibits impressive accuracy and robustness in terms of different driving-risk levels.
Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathways

A transcription factor family and a phosphatase are identified as targets of ALK signaling in neuroblastoma. Alternatives to ALK in neuroblastoma Neuroblastoma is a common pediatric solid tumor that is often driven by oncogenic mutations or rearrangements of the gene encoding the tyrosine kinase receptor ALK. In relapsed neuroblastoma, the frequency of ALK mutation is increased, highlighting the importance of understanding ALK signaling in this cancer. Two papers identify alternative targets in ALK-driven neuroblastoma cells. By combining various proteomics analyses with protein-protein interaction networks, Emdal et al. found that IRS2, an adaptor protein in the insulin receptor signaling pathway, linked ALK signaling to neuroblastoma cell survival. Van den Eynden et al. integrated proteomics and gene expression analyses to identify ETS family transcription factors and the MAPK phosphatase DUSP4 as targets of ALK signaling. These papers identify new targets that could be exploited to treat ALK-positive neuroblastoma. Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor that is a clinical target of major interest in cancer. Mutations and rearrangements in ALK trigger the activation of the encoded receptor and its downstream signaling pathways. ALK mutations have been identified in both familial and sporadic neuroblastoma cases as well as in 30 to 40% of relapses, which makes ALK a bona fide target in neuroblastoma therapy. Tyrosine kinase inhibitors (TKIs) that target ALK are currently in clinical use for the treatment of patients with ALK-positive non–small cell lung cancer. However, monotherapy with the ALK inhibitor crizotinib has been less encouraging in neuroblastoma patients with ALK alterations, raising the question of whether combinatorial therapy would be more effective. In this study, we established both phosphoproteomic and gene expression profiles of ALK activity in neuroblastoma cells exposed to first- and third-generation ALK TKIs, to identify the underlying molecular mechanisms and identify relevant biomarkers, signaling networks, and new therapeutic targets. This analysis has unveiled various important leads for novel combinatorial treatment strategies for patients with neuroblastoma and an increased understanding of ALK signaling involved in this disease.
High Performance Parallel Database Processing and Grid Databases

This book targets the theoretical/conceptual details needed to form a base of understanding and then delivers information on development, implementations, and analytical modeling of parallel databases. It includes key information on new developments with grid databases. Also uses a theoretical and practical balance to support in-depth study of parallel query processing offered by modern DBMS as well as hands on experience of parallel query algorithms development, implementation, and analysis.
The effects of joint flexibility on robot motion control based on joint torque positive feedback

When positive feedback of joint torques is applied to the motion control of robot arms, the nonlinear dynamic couplings between links are canceled and a servo system with high stiffness is obtained. The problems which arise due to joint flexibility in robot motion control based on joint torque positive feedback are discussed. The effects of joint flexibility are investigated by numerical and experimental studies on a one-link arm with a harmonic drive. It is shown that the joint flexibility destabilizes the control system with joint torque positive feedback. A low-pass filter is used in the torque feedback loop to improve the oscillation characteristics of the control scheme. <<ETX>>
Invasiveness‐triggered state transition in malignant melanoma cells

Cancer cells are considered to have high morphological heterogeneity in human melanoma tissue. Here, we report that epithelial cancer cells are dominant in different development stages of human melanoma tissues. The cellular and molecular mechanisms that maintain melanoma cells in the epithelial state are further investigated in the A2058 cell line. We find that micropore (8 µm) transwell invasion, but not superficial migration in the scratch assay, can induce remarkable morphological changes between epithelial and mesenchymal melanoma cells within 4 days. The morphological switch is associated with dynamic changes of epithelial–mesenchymal transition (EMT) hallmarks E‐cadherin and vimentin. Further immunoflurencent staining and co‐immunoprecipitation assay showed the uncoupling of the M3 muscarinic acetylcholine receptor (mAChR) and the p75 neurotrophin receptor (p75NTR) in epithelial melanoma cells. Specific knockdown of M3 mAChR by small interfering RNA (siRNA) significantly abrogates the transition of spindle‐shaped mesenchymal cells to epithelial cells. Collectively, we report a cellular model of invasiveness‐triggered state transition (ITST) in which melanoma cell invasion can induce morphological changes between epithelial and mesenchymal cells. ITST is one of the biological basis for maintaining metastatic melanoma cells in the epithelial state. Furthermore, M3 mAChR receptor‐mediated ITST provides a novel therapeutic strategy to inhibit the development of malignant melanoma.
Detection and analysis of low-level temperature inversions with MODIS

Low-level atmospheric temperature inversions are ubiquitous at high latitudes during the polar winter. It has previously been shown that strong inversions over the Antarctic continent can be detected by examining the brightness temperature difference (BTD) between a water vapor absorption band at 6.7 /spl mu/m and the infrared window at 11 /spl mu/m. Under clear sky conditions this brightness temperature difference will be negative because the water vapor band, with a weighting function that peaks near 500 hPa, senses the warmer atmosphere near the top of the inversion while the window channel temperature is controlled primarily by surface emission. However, the method is not generally applicable to weaker or shallower inversions that are common in the Arctic and some parts of the Antarctic continent. In this paper we extend the work of Ackerman (1996) on inversion detection by incorporating two spectral bands whose weighting functions peak lower in the troposphere: the 7.2 /spl mu/m water vapor band and the 13.3 /spl mu/m carbon dioxide band of the Moderate-Resolution Imaging Spectroradiometer (MODIS). The brightness temperature differences 11-6.7 /spl mu/m, 11-7.2 /spl mu/m, and 13.2 /spl mu/m are used to detect the presence and magnitude of low-level atmospheric temperature inversions under clear sky conditions during the polar night.
PERSISTENT INCREASE IN PLASMA AND URINARY LEUKOTRIENES AFTER ACUTE ASTHMA

Purpose of the Study. With the role of leukotrienes in the inflammatory cycle of asthma well accepted, the present study set out to measure various leukotriene levels in asthmatic children during and 1 month after an acute asthmatic attack. Methods. Plasma and urinary leukotrienes were evaluated using a high-performance liquid chromatography/radioimmunoassay in 10 children 5-10 years of age with acute asthma as documented by peak expiratory flow rates at the onset of an episode and 1 month after when their peak expiratory flow rates returned to normal. The children were all from atopic backgrounds and three were on long-term inhaled anti-inflammatory therapy. They were matched by age-appropriate normal children who had the same plasma and urinary determinations performed. Results. Plasma concentrations of both leukotrines B4 and E4 were significantly increased during the acute phase but also 1 month later when compared with the normals. The urinary levels of leukotrine E4 were the most strikingly elevated initially and at the 1-month follow-up. Reviewer's Comments. Physicians caring for the diabetic patient have the hemoglobin A-1-C determination as a gauge of diabetic control to supplement daily glucose readings. Urinary leukotrine E4 levels or similar markers may well provide the physician with useful data as to the state of the inflammatory process in the asthmatic's lung. An extension of the project for a longer time period would be most interesting especially if the urinary levels continued to be reliable. This noninvasive source of information certainly is preferable to endotracheal biopsy or bronchoalveolar lavage, two current choices.
Association between problematic Internet use, sleep disturbance, and suicidal behavior in Chinese adolescents

Background and aims This large-scale study aimed to test (a) associations of problematic Internet use (PIU) and sleep disturbance with suicidal ideation and suicide attempts among Chinese adolescents and (b) whether sleep disturbance mediates the association between PIU and suicidal behavior. Methods Data were drawn from the 2017 National School-based Chinese Adolescents Health Survey. A total of 20,895 students’ questionnaires were qualified for analysis. The Young’s Internet Addiction Test was used to assess PIU, and level of sleep disturbance was measured by the Pittsburgh Sleep Quality Index. Multilevel logistic regression models and path models were utilized in analyses. Results Of the total sample, 2,864 (13.7%) reported having suicidal ideation, and 537 (2.6%) reported having suicide attempts. After adjusting for control variables and sleep disturbance, PIU was associated with an increased risk of suicidal ideation (AOR = 1.04, 95% CI = 1.03−1.04) and suicide attempts (AOR = 1.03, 95% CI = 1.02−1.04). Findings of the path models showed that the standardized indirect effects of PIU on suicidal ideation (standardized β estimate = 0.092, 95% CI = 0.082−0.102) and on suicide attempts (standardized β estimate = 0.082, 95% CI = 0.068−0.096) through sleep disturbance were significant. Conversely, sleep disturbance significantly mediated the association of suicidal behavior on PIU. Discussion and conclusions There may be a complex transactional association between PIU, sleep disturbance, and suicidal behavior. The estimates of the mediator role of sleep disturbance provide evidence for the current understanding of the mechanism of the association between PIU and suicidal behavior. Possible concomitant treatment services for PIU, sleep disturbance, and suicidal behavior were recommended.
Dopamine D2/3 Binding Potential Modulates Neural Signatures of Working Memory in a Load-Dependent Fashion

Dopamine (DA) modulates corticostriatal connections. Studies in which imaging of the DA system is integrated with functional imaging during cognitive performance have yielded mixed findings. Some work has shown a link between striatal DA (measured by PET) and fMRI activations, whereas others have failed to observe such a relationship. One possible reason for these discrepant findings is differences in task demands, such that a more demanding task with greater prefrontal activations may yield a stronger association with DA. Moreover, a potential DA–BOLD association may be modulated by task performance. We studied 155 (104 normal-performing and 51 low-performing) healthy older adults (43% females) who underwent fMRI scanning while performing a working memory (WM) n-back task along with DA D2/3 PET assessment using [11C]raclopride. Using multivariate partial-least-squares analysis, we observed a significant pattern revealing positive associations of striatal as well as extrastriatal DA D2/3 receptors to BOLD response in the thalamo–striatal–cortical circuit, which supports WM functioning. Critically, the DA–BOLD association in normal-performing, but not low-performing, individuals was expressed in a load-dependent fashion, with stronger associations during 3-back than 1-/2-back conditions. Moreover, normal-performing adults expressing upregulated BOLD in response to increasing task demands showed a stronger DA–BOLD association during 3-back, whereas low-performing individuals expressed a stronger association during 2-back conditions. This pattern suggests a nonlinear DA–BOLD performance association, with the strongest link at the maximum capacity level. Together, our results suggest that DA may have a stronger impact on functional brain responses during more demanding cognitive tasks. SIGNIFICANCE STATEMENT Dopamine (DA) is a major neuromodulator in the CNS and plays a key role in several cognitive processes via modulating the blood oxygenation level-dependent (BOLD) signal. Some studies have shown a link between DA and BOLD, whereas others have failed to observe such a relationship. A possible reason for the discrepancy is differences in task demands, such that a more demanding task with greater prefrontal activations may yield a stronger association with DA. We examined the relationship of DA to BOLD response during working memory under three load conditions and found that the DA–BOLD association is expressed in a load-dependent fashion. These findings may help explain the disproportionate impairment evident in more effortful cognitive tasks in normal aging and in those suffering dopamine-dependent neurodegenerative diseases (e.g., Parkinson's disease).
Photonic Crystal Devices in Silicon Photonics

In this paper, we review the history of 2-D photonic crystal slabs with a focus on point-defect cavities that can simultaneously realize ultrasmall modal volumes and ultrahigh quality factors. An important design concept to suppress radiation loss is introduced: the envelope of the cavity mode field should have no abrupt changes and should ideally follow a Gaussian function. Cubic-wavelength-order modal volumes, with experimental <inline-formula> <tex-math notation="LaTeX">$\mathit {Q}$ </tex-math></inline-formula> factors exceeding 11000000, are obtained by tailoring the envelope functions using heterostructure nanocavities. We also discuss light/photon manipulation techniques, which are enabled by the emergence of high-<inline-formula> <tex-math notation="LaTeX">$\mathit {Q}$ </tex-math></inline-formula> photonic crystal nanocavities, including ultracompact channel add/drop filters, ultralow-threshold silicon nanocavity Raman lasers, and strong coupling between distant nanocavities via the adiabatic transfer of photons.
Product review: avelumab, an anti-PD-L1 antibody

ABSTRACT Although immunotherapies have been employed for many decades, immune checkpoint inhibitors have only recently entered the oncologic landscape. Avelumab is a fully human monoclonal antibody that blocks the interaction between PD-L1 on tumor cells and PD-1 on T cells, thereby inhibiting immunosuppression in the tumor microenvironment and reducing tumor growth. Most early clinical trials of avelumab as monotherapy and in combination regimens were part of the international JAVELIN clinical trial program, which included more than 7000 patients in more than 30 trials with at least 15 tumor types. Avelumab has been approved by the U.S. FDA for the treatment of metastatic Merkel cell carcinoma and metastatic urothelial carcinoma that has progressed during or following treatment with a platinum-based regimen. Its acceptable safety profile and ability to induce durable responses in otherwise deadly tumors provide the rationale for its use in other tumor types and in combination with other therapies.
Developing novel Ca-zeolite/poly(amino acid) composites with hemostatic activity for bone substitute applications

Abstract The novel Ca-zeolite/poly(amino acid) (CaY/PAA) composites for bone substitute applications with hemostatic activity were prepared using the in situ melting polymerization method. In this study, Ca-zeolite (CaY) loaded with Ca2+ was obtained from Y-type zeolite (NaY) by ion-exchange method. The properties of the CaY/PAA composites and PAA, including composition, structure, compressive strength, in vitro degradability in phosphate-buffered solution (PBS), bioactivity, cytocompatibility and in vitro coagulation tests were characterized and investigated. The results showed that compressive strength of the CaY/PAA composites ranged from 145 to 186 MPa, demonstrating sufficient mechanical strength for load-bearing bone substitute. After soaking in PBS for 16 weeks, the weight loss of 25CaY/PAA and 50CaY/PAA were 4.1 and 1.6 wt%, respectively, and the pH values for CaY/PAA composites increased to about 8.0 in 2 weeks and then gradually stabilized around 7.4, indicating good stability in PBS. Scanning electron microscope and energy dispersive spectrometer results showed that the composites were bioactive and new apatite layers attached on their surfaces. Mesenchymal stem cells (MSCs) exhibited high-proliferation in the extract solution of the CaY/PAA composites and were well spread on the surfaces of the composites. Cells on the CaY/PAA composite groups showed higher alkaline phosphatase (ALP) activity indicating the potential to promote cell differentiation. The in vitro coagulation tests showed that CaY/PAA composites have shorter clotting time and better performance of promoting blood coagulation than other samples, presenting improved hemostatic activity. In summary, the results demonstrated that the CaY/PAA composites had good mechanical strength, stability, bioactivity, cytocompatibility and hemostatic activity for bone substitute applications.
Changing concepts in hematopoietic stem cells

Analyses of platelet and red blood cell lineages are redefining how we consider stemness Hematopoietic stem cells (HSCs) can produce all cell lineages within the adult blood system, and they have provided a flagship model in which to study stem cell biology. Concepts developed from studying HSCs have influenced how we consider other stem cell systems. HSCs are also one of the few stem cell types with a long history of clinical application, in the form of bone marrow transplantation. Recent technical advances have brought about a major revision in our understanding of the HSC compartment. These necessitate new models and nomenclature to describe HSC heterogeneity, self-renewal, and differentiation potential, as well as having broader implications for how we consider stemness.
Time-delay Tolerant Control of an Omnidirectional Multi-agent System for Transport Operations

This paper proposes a solution regarding the general consensus of a multi-agent time-delay system in order to achieve interactive and transport operations. The multi-agent system consists of a set of omni directional mobile robots equipped with vision based systems and interactive tools. It is well known that the vision-based systems and the communication between agents produce time-delays, causing stability issues for consensus and formation control. The present work deals with a high precision consensus by means of a time-delay tolerant control law. First, the mathematical model of every agent is presented. Then, this dynamic model is extended to the set of robots conforming the multi-agent system. After that, a control law, consisting of a time-delay tolerant strategy allows orientation and position consensus. The formulation of a simple algorithm for orientation and position formations for the set of robots is presented. Finally, simulation results validate the proposed control strategy and compare the results when time-delay is present in the system or not for an object transport scenario.
ASI Panduan Praktis Ibu Menyusui

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