Miracle-dz/UniFAR-FTUs huggingface dataset:
young adults ' decisions to become organ donors Gifts of giving : The role of empathy and perceived benefits to others and self in

Trait empathy and self-interest exert a strong influence on different prosocial behaviors, but their role in the promotion of organ donation registration is unclear. A survey examined how perceived benefits of organ donation for others and the self affect people’s willingness to register as donors. Perceived other-benefits did not predict registration. Those with lower risk and greater self-benefit perceptions were more willing to donate. Empathic concern predicted donation willingness and moderated the effect of other-benefit perceptions, such that other-benefit perceptions predicted donation willingness among those with greater empathic concern. Applications of these findings to organ donation promotion are discussed.
Title : Thermal limits of leaf metabolism across biomes Running head : Thermal limits of plants

High-temperature tolerance in plants is important in a warming world, with extreme heatwaves predicted to increase in frequency and duration, potentially leading to lethal heating of leaves. Global patterns of high-temperature tolerance are documented in animals, but generally not plants, limiting our ability to assess risks associated with climate warming. To assess whether there are global patterns in high-temperature tolerance of leaf metabolism, we quantified Tcrit (high temperature where minimal chlorophyll a fluorescence rises rapidly, and thus where photosystem II is disrupted) and Tmax (temperature where leaf respiration in darkness is maximal, beyond which respiratory function rapidly declines) in upper-canopy leaves of 218 plant species spanning seven biomes. Mean site-based Tcrit values ranged from 41.5 °C in the Alaskan arctic to 50.8 °C in lowland tropical rainforests of Peruvian Amazon. For Tmax, the equivalent values were 51.0 and 60.6 °C in the Arctic and Amazon, respectively. Tcrit and Tmax followed similar biogeographic patterns, increasing linearly (~8 °C) from polar to equatorial regions. Such increases in high temperature tolerance are much less than expected based on the 20 °C span in high temperature extremes across the globe. Moreover, with only modest high-temperature tolerance despite high summer temperature extremes, species in mid-latitude (~20°-50°) regions have the narrowest thermal safety margins in upper-canopy leaves; these regions are at the greatest risk of damage due to extreme heat-wave events, especially under conditions when leaf temperatures are further elevated by a lack of transpirational cooling. Using predicted heat-wave events for 2050 and accounting for possible thermal acclimation of Tcrit and Tmax, we also found that these safety margins could shrink in a warmer world, as rising temperatures are likely to exceed thermal A cc ep te d A rt ic le This article is protected by copyright. All rights reserved. tolerance limits. Thus, increasing numbers of species in many biomes may be at risk as heatwave events become more severe with climate change.
Novel role for the testis-enriched HSPA 2 protein in regulating epidermal keratinocyte differentiation † Running head : HSPA 2 in keratinocyte differentiation

1 Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, 44101 Gliwice, Poland. 2 Medical University of Silesia in Katowice, Department of Molecular Biology and Genetics, 40-752 Katowice, Poland. 3 Nencki Institute of Experimental Biology Polish Academy of Science, 02-093 Warsaw, Poland. 4 International Institute of Molecular and Cell Biology in Warsaw, 02-109 Warsaw, Poland.
Estimating response times of Vadret da Morteratsch, Vadret da Palu ¨ , Briksdalsbreen and Nigardsbreen from their length records

Length records of two pairs of glaciers are used to reconstruct the equilibrium-line altitude (ELA) and to estimate glacier response times. The method is based on the assumption that neighbouring glaciers should be subject to the same climatic forcing, and that differences in the length records are thus caused by differences in response times and climate sensitivities. By means of a control method, in which the difference between the reconstructed histories of the ELA is minimized, realistic response times are found. The pairs of glaciers studied are: (i) Vadret da Morteratsch and Vadret da Paluin the Swiss Alps and (ii) Briksdalsbreen and Nigardsbreen in southern Norway. In both cases the reconstructed ELA histories of the individual glaciers are very similar, in spite of the large differences in the length records. Short e-folding response times are found for the steep glaciers: 4.4 years for Vadret da Palii, 5.0 years for Briksdalsbreen. For the larger glaciers with a more gentle slope the response times are substantially larger: 33.0 years for Vadret da Morteratsch, 34.8 years for Nigardsbreen.
The Effect of Exchange Rate Uncertainty On Interest Rate in Turkey

The emergence of freely floating exchange rate systems along with the globalization of financial markets has increased the significant movements in the exchange rates. Concerning with this process, our paper tries to empirically indicate how monthly exchange rate volatility and interest rate are linked in Turkey during 2002 to 2011. We proxy the uncertainty of exchange rate with the conditional variance of monthly exchange rate data using GARCH Model specification. Then we test the causality between inflation uncertainty and interest rate using Granger Causality Test and Impulse Response Analysis. Empirical results indicate that the interest rates increase with the higher level of exchange rate uncertainty leading to additional risk premium. These findings also present significant concerns for policy makers adopting the Inflation Targeting after 2001 in Turkey.
Similar Effects of Colchicine and Low Temperature on Initiation and Elongation of Stems in Bulblets Developed on Scales of 'White Aga' (Lilium x formolongi) Cultured In Vitro

Factors affecting the initiation and elongation of stems from bulblets developed on the scales of ‘White Aga’ (Lilium x formolongi) were examined by low-temperature treatment of bulbscales cultured in darkness or by culturing them in a medium with colchicine at 25°C. Scale explants excised from in vitro-cultured bulblets were cultured for a total of 180 days in darkness. First, they were cultured in MS medium with 0.54 µM NAA and 4.4 or 44 µM BA at 25°C for 30 days, and then further subcultured under the following conditions: (1) continuously cultured at 25°C for 150 days (control) on MS medium with 4.4 µ µ µ µM BA; (2) cultured at 8°C for 60 days, followed by culture at 25°C for 90 days (low-temperature treatment) on MS medium with 4.4 µM BA; (3) cultured on MS medium with 4.4 µM BA and 1 µ µ µ µM or 10 µM of colchicine at 25°C for 30 days, followed by culture on MS medium with 4.4 µM BA at 25°C for 120 days (colchicine treatment). Stem elongation from bulblets developing on the scales was observed in bulblets subjected to both low-temperature and colchicine treatment. Since both treatments, which inhibit the polymerization of microtubules (MTs) and stimulate the depolymerization of MTs, affected stem elongation from bulblets, there might be some relationship between the inhibition of polymerization as well as the stimulation of depolymerization of MTs and the induction and elongation of stems in bulblets.
blood samples of sheep , cattle , and alpaca real-time reverse transcription polymerase chain reaction assay results in Bluetongue virus Variation in

Bluetongue is a vector-borne viral disease that affects domestic and wild ruminants. The epidemiology of this disease has recently changed, with occurrence in new geographic areas. Various real-time quantitative reverse transcription polymerase chain reaction (real-time qRT-PCR) assays are used to detect Bluetongue virus (BTV); however, the impact of biologic differences between New World camelids and domestic ruminant samples on PCR efficiency, for which the BTV real-time qRT-PCR was initially validated are unknown. New world camelids are known to have important biologic differences in whole blood composition, including hemoglobin concentration, which can alter PCR performance. In the present study, sheep, cattle, and alpaca blood were spiked with BTV serotypes 10, 11, 13, and 17 and analyzed in 10-fold dilutions by real-time qRT-PCR to determine if species affected nucleic acid recovery and assay performance. A separate experiment was performed using spiked alpaca blood subsequently diluted in 10-fold series in sheep blood to assess the influence of alpaca blood on performance efficiency of the BTV real-time qRT-PCR assay. Results showed that BTV-specific nucleic acid detection from alpaca blood was consistently 1–2 logs lower than from sheep and cattle blood, and results were similar for each of the 4 BTV serotypes analyzed.
Measuring business-to-business customer service: A structural re-examination of the INDSERV scale

Theory and empirical evidence suggest that the dimensions of business-to-business customer service differ to individual service. In response, Gounaris (2005a; b) developed the INDSERV business-tobusiness customer service scale, the sub-scales of which are potential quality, hard process quality, soft process quality and outcome quality. INDSERV seems to be a valid and superior scale for business-to-business settings. However, Gounaris treats the four internal dimensions as indicators of a single latent “B2B service” factor. This paper argues that researchers should model the INDSERV dimensions as a process, rather with potential quality being an antecedent of hard and soft process quality, and all three being antecedents of outcome quality. This argument is tested through structural equation tests both of original Gounaris (2005c) covariances and a new dataset from 170 supply dyads in South Africa. The results generally support the alternate conception of business-to-business customer service. Modelling customer service in this way allows more complex and interesting model generation. Allowing direct relationships between the indicators of INDSERV, and differential relationships of these with other variables, allows for broader hypothesis development and therefore greater expansion of the theory. Various implications arise for marketing and other practices and researches.
Dual spacecraft determinations of magnetopause motion

We examine the motion of Earth's magnetopause for 16 dawnside traversals of this boundary by the sister spacecraft AMPTE/UKS and IRM in December, 1984, when their separation was 400–900 km. We compare magnetopause normal vectors, n, and speeds of motion, un, obtained separately from each spacecraft by use of three different methods, and also compare those un to corresponding speeds, un*, obtained from observed time lags between the two spacecraft. Agreement between un values and n vectors determined from the three methods ranges from poor to excellent. Comparing un* and un values, we find a clear tendency for |un*| to be larger than |un|: While slightly less than half of the results show reasonable agreement (0.5 < un/un* < 2), there are about as many results in the range 0 < un/un* < 0.5, and a few cases give the wrong sign of un.
Word Image Segmentation Word Image Query DoLF Extraction Matching Ranking List Database DoLF Extraction Document Image Dataset ONLINE

Word spotting strategies employed in historical handwritten documents face many challenges due to variation in the writing style and intense degradation. In this paper, a new method that permits effective word spotting in handwritten documents is presented that it relies upon document-oriented local features which take into account information around representative keypoints as well a matching process that incorporates spatial context in a local proximity search without using any training data. Experimental results on four historical handwritten datasets for two different scenarios (segmentation-based and segmentation-free) using standard evaluation measures show the improved performance achieved by the proposed methodology.
Countering hepatit RNAi : how far are Reviews in Medical Virology

Globally, persistent HBV infection is a significant cause of public health problems. Currently available HBV therapies have variable efficacy and there is a need to develop improved treatment to prevent cirrhosis and hepatocellular carcinoma. Although RNA interference (RNAi)-based approaches have shown promise, accomplishing safe and sustained silencing by RNAi activators, as well as their efficient delivery to hepatocytes have hampered clinical translation of this very promising technology. Expressed silencers may be produced in a sustained manner from stable DNA templates, which makes them suited to treatment of chronic HBV infection. DNA expression cassettes can be incorporated into both viral and non-viral vectors, but in vivo delivery of these cassettes with non-viral vectors is currently inefficient. Synthetic short interfering RNAs (siRNAs), which may be chemically modified to improve stability, specificity and efficacy, are more conveniently delivered to their cytoplasmic sites of action with synthetic non-viral vectors. However, the short duration of action of this class of RNAi activator is a drawback for treatment of chronic HBV infection. Despite the impressive progress that has been made in developing highly effective HBV gene silencers, challenges continue to face implementation of RNAi-based HBV therapy. This review will discuss the current status of the topic and consider the developments that are required to advance RNAi-based HBV therapy to clinical application. Copyright © 2011 John Wiley & Sons, Ltd.
in MET-Dependent Proliferation miRNA Profiling in Colorectal Cancer Highlights miR-1 Involvement

Altered expression of miRNAs is associated with development and progression of various human cancers by regulating the translation of oncogenes and tumor suppressor genes. In colorectal cancer, these regulators complement the Vogelstein multistep model of pathogenesis and have the potential of becoming a novel class of tumor biomarkers and therapeutic targets. Using quantitative real-time PCR, wemeasured the expression of 621 mature miRNAs in 40 colorectal cancers and their paired normal tissues and identified 23 significantly deregulated miRNAs. We subsequently evaluated their association with clinical characteristics of the samples and presence of alterations in the molecular markers of colorectal cancer progression. Expression levels of miR-31 were correlated with CA19-9 and miR-18a, miR-21, and miR-31 were associated with mutations in APC gene. To investigate the downstream regulation of the differentially expressed miRNAs identified, we integrated putative mRNA target predictions with the results of a meta-analysis of seven public gene expression datasets of normal and tumor samples of colorectal cancer patients.Many of the colorectal cancer deregulatedmiRNAs computationallymapped to targets involved in pathways related to progression. Here one promising candidate pair (miR-1 andMET) was studied and functionally validated. We show that miR-1 can have a tumor suppressor function in colorectal cancer by directly downregulatingMEToncogene both at RNAandprotein level and that reexpression ofmiR-1 leads toMET-driven reduction of cell proliferation and motility, identifying the miR-1 downmodulation as one of the events that could enhance colorectal cancer progression. Mol Cancer Res; 10(4); 504–15. 2012 AACR.
V Improved Live VM Migration using LRU and Splay Tree Algorithm

Live migration is a technology with which an entire running virtual machine (VM) is moved from one physical machine to another. Migration at the level of an entire VM means that in-memory state can be transferred in a consistent and efficient fashion. In pre-copy approach that is mainly used in live migration, total migration time which affect on the performance of VM, is prolonged by iterative copy operations and the significant amount of transferred data during the whole migration process. In this paper, we presented a framework that includes pre-processing phase in traditional pre-copy based live migration for reducing the amount of transferred data. In preprocessing phase, we propose the prediction working set algorithm. Applying the proposed algorithm which combined LRU (Least Recent Used) cache with splay tree algorithm, the system can reduce the amount transferred memory page. We evaluated the effectiveness of the working set prediction algorithm with various workloads. Experiment demonstrates that compared with XEN’s default pre-copy based migration algorithm, the proposed framework can reduce 23.67% of the total data transferred during migration and 11.45% of total migration time on average.
Financial Development and Armed Conflict A Cross-country Analysis

In this paper we have examined how armed conflict and financial development is associated using a panel of 66 developing countries for the period 1985-2010. Financial development has been measured by two proxy indicators: M2 as a share of GDP and credit allocated to private sector by banks as a share of GDP. Our findings suggest that armed conflict has significant adverse effect on financial development. In addition, quality of governance is found highly significant and conducive to the financial development. In one hand, govern-ance quality appears with greater impact towards credit allocated to private sec-tor as the effect of armed conflict seems insignificant. On the other hand, ef-fect of armed conflict towards M2 as a percentage of GDP gets smaller; however, significant in the presence of governance quality. This paper also ex-plores that the negative effect of armed conflict increases as armed conflict intensifies. However, governance performances seem trading off with low and medium intensity of armed conflict. That implies governance quality does mat-ter but cannot offset entirely the effect of high intensity armed conflict and its effect by retarding M2 as a share of GDP.
Contrast Effects of Vegetation Cover Change on Evapotranspiration during a Revegetation Period in the Poyang Lake Basin, China

It is known that evapotranspiration (ET) differs before and after vegetation change in watersheds. However, impacts of vegetation change on ET remain incompletely understood. In this paper, we investigated the process-specific, nonclimatic contribution (mainly vegetation coverage changes) to ET at grid, sub-basin, and basin scales using observation and remote sensing data. The Poyang Lake Basin was selected as the study area, which experienced a fast vegetation restoration from 1983 to 2014. Our results showed that vegetation cover change produced contrasting effects on annual ET in magnitude and direction during shifts from a less covered to a more covered stage. At the early stage (1983–1990), with vegetation cover of 30%, vegetation cover change produced negative effects on ET over the basin. At the middle stage (1990–2000), the vegetation coverage increased at a fast pace and the negative effects gradually shifted to positive. At the late stage (2000–2014), the vegetation coverage remained high (over 60%) and maintained a positive relationship with ET. In summary, the vegetation effects are collaboratively influenced by both vegetation coverage and its change rate. Our findings should be helpful for a comprehensive understanding of complicated hydrological responses to anthropogenic revegetation.
A retrospective study of endometrial histopathology in abnormal uterine bleeding patients

Background: Abnormal uterine bleeding (AUB) is one of the most commonly encountered gynecological problem and almost 33 % of women in gynecological outpatient department presented with abnormal uterine bleeding. Dilatation and curettage (D and C) have been the main diagnostic procedure in the evaluation of abnormal uterine bleeding patients for decades. The objective of the present study was to analyze the different types of endometrial histopathology of patients presented with the abnormal uterine bleeding and its correlation with the different types of abnormal uterine bleedingMethods: This is a retrospective study, conducted in a medical college in the Department of Obstetrics and Gynecology over a period of one year from June ’17 to June ’18. All cases of AUB more than 35 years of the age group who underwent D and C procedure were included in this study. Total 100 patients were analyzed.Results: Total 100 patients were analyzed. Age group ranges from 35-58 years and most common age group presenting with AUB was 35-39 years. The most common presenting complaint was menorrhagia 54% (54/100). Histopathology of endometrium showed non-organic causes in 80% (80/100) of AUB patients and the remaining 20% (20/100) had organic causes. Most common endometrial histopathology among non-organic causes was proliferative endometrium 43.75% (35/80) and the most common organic cause was endometrial polyp 40% (8/20). Endometrial hyperplasia was found in 30% (6/20) and endometrial carcinoma was found in 20% (4/20) of cases among organic causes.Conclusions: D and C is the useful and the cost-effective diagnostic procedure in the evaluation of AUB. Histopathological evaluation of endometrial samples is especially indicated in AUB patients to rule out carcinoma and preneoplastic conditions as histopathology is 100% diagnostic in cases of endometrial hyperplasia and carcinoma.
Preprocessed discrete Moser-Veselov algorithm for the full dynamics of a rigid body

The discrete Moser? Veselov algorithm is an integrable discretization of the equations of motion for a free rigid body. It is symplectic and time reversible, and it conserves all first integrals of the system. The only drawback is its low order. We present a modification of this algorithm to arbitrarily high order which has negligible overhead but considerably improves the accuracy.
Cardiovascular Actions of Hydrogen Sulfide and Other Gasotransmitters The interaction of estrogen and CSE / H 2 S pathway in the development of atherosclerosis

Hongzhu Li,* Sarathi Mani,* Lingyun Wu, Ming Fu, Tian Shuang, Changqing Xu, and Rui Wang Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada; Department of Pathophysiology, Harbin Medical University, Harbin, People’s Republic of China; Cardiovascular and Metabolic Research Unit, Laurentian University, Sudbury, Ontario, Canada; Health Sciences North Research Institute, Sudbury, Ontario, Canada; and Department of Biology, Laurentian University, Sudbury, Ontario, Canada
Patients With 2-to 5-Year Follow-up Arthroscopic Glenoid Bone Grafting With Nonrigid Fixation for Anterior Shoulder Instability : 52

http://ajs.sagepub. com/content/42/4/831 The online version of this article can be found at: DOI: 10.1177/0363546513519227 2014 42: 831 originally published online February 7, 2014 Am J Sports Med Jinzhong Zhao, Xiaoqiao Huangfu, Xingguang Yang, Guoming Xie and Caiqi Xu Patients With 2to 5-Year Follow-up Arthroscopic Glenoid Bone Grafting With Nonrigid Fixation for Anterior Shoulder Instability: 52
BPA causes adverse effects on reproductive tracts including decreased epididymal weight , daily sperm production ( vom

Bisphenol-A (BPA) is well known as one of endocrine-disrupting chemicals and testicular toxicant. In this present study, we determined whether BPA caused cell injury through mitochondria impairment and ROS overproduction. The cellular ROS production, mitochondrial ATP synthetase activity and Ca concentration were examined. We have found BPA caused the cellular mitochondria dysfunction and followed by cell death in Sertoli cells. Moreover cytoplasm Ca overload was also involved. Furthermore, pretreatment with N-acetyl-L-cysteine (NAC) could alleviate the damage by causing a remarkable decrease in ROS production and mitochondrial dysfunction. Collectively, our results showed that BPA exposure induced Sertoli cell apoptosis because of excessive ROS generation and mitochondrial dysfunction. VC 2016 Wiley Periodicals, Inc. Environ Toxicol 00: 000–000, 2016.