Miracle-dz/UniFAR-FTUs huggingface dataset:
Study Protocol: Determining Research Priorities of Young Albertan Families (The Family Research Agenda Initiative Setting Project—FRAISE)—Participatory Action Research

Introduction: Pregnancy and childrearing can be an exciting and stressful time for new parents. The maternal-child health landscape has changed dramatically over the last few decades and research priorities need to address these rapid changes. There have been limited attempts to engage and collaborate with members of the public to develop research priorities for families who are expecting or parenting an infant to age 24 months. The work that has been completed has attempted to identify parental preference for information delivery and barriers to uptake of parenting programs but has not investigated parental research priorities. Methods: In collaboration with provincial research units and strategic clinical networks (SCN), we will use principles of participatory action research (PAR) as our theoretical framework/method, and a modified James Lind Alliance priority setting approach to prioritize a list of research questions that parents/knowledge users believe will support the health of their families. This will result in a top 10 list of parent/knowledge user-identified research priorities. This project will consist of three phases. In the first phase, we developed a steering committee of parents/knowledge users, healthcare providers, community agencies, and researchers to design a survey about health priorities for families. In the second phase, we will distribute the survey to diverse groups of parents/knowledge users/providers and hold a series of meetings to identify and prioritize potential questions from new parents about health issues from conception to age 24 months. In the third phase, we will collaboratively disseminate and translate findings. Discussion: This study will highlight parental health concerns and recommend parent-identified research priorities to inform future research projects needed to support the health of families between conception to age 24 months. Understanding the health research priorities of families in the community will help ensure future research contributes to meaningful changes in the health of young children, parents/knowledge users, and families. Ethics: This study and protocol have received ethical approved from the Conjoint Health Research Ethics Board at the University of Calgary (REB17-0014). Dissemination: The top 10 research priorities will be published and additional findings from the study will be distributed through pamphlets and newsletters.
Placing search in context: the concept revisited

Keyword-based search engines are in widespread use today as a popular means for Web-based information retrieval. Although such systems seem deceptively simple, a considerable amount of skill is required in order to satisfy non-trivial information needs. This paper presents a new conceptual paradigm for performing search in context, that largely automates the search process, providing even non-professional users with highly relevant results. This paradigm is implemented in practice in the IntelliZap system, where search is initiated from a text query marked by the user in a document she views, and is guided by the text surrounding the marked query in that document (“the context”). The context-driven information retrieval process involves semantic keyword extraction and clustering to automatically generate new, augmented queries. The latter are submitted to a host of general and domain-specific search engines. Search results are then semantically reranked, using context. Experimental results testify that using context to guide search, effectively offers even inexperienced users an advanced search tool on the Web.
FGF10 Is Required for Circumvallate Papilla Morphogenesis by Maintaining Lgr5 Activity

Taste buds develop in different regions of the mammal oral cavity. Adult stem cells in various organs including the tongue papillae are marked by leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) and its homolog, Lgr6. Recent studies have reported that adult taste stem/progenitor cells in circumvallate papilla (CVP) on the posterior tongue are Lgr5-positive. In this study, we confirm the Lgr5 expression pattern during CVP development. A previous study reported that mesenchymal Fgf10 is necessary for maintaining epithelial Lgr5-positive stem/progenitor cells. To confirm the interaction between Lgr5-positive CVP epithelium and mesenchymal factor FGF10, reverse recombination (180-degree) was performed after tongue epithelium detachment. FGF10 protein-soaked bead implantation was performed after reverse recombination to rescue CVP development. Moreover, we reduced mesenchymal Fgf10 by BIO and SU5402 treatment which disrupted CVP morphogenesis. This study suggests that the crosstalk between epithelial Lgr5 and mesenchymal Fgf10 plays a pivotal role in CVP epithelium invagination during mouse tongue CVP development by maintaining Lgr5-positive stem/progenitor cells.
Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells

The Wnt/β-catenin signaling pathway is known to play critical roles in a wide range of cellular processes: cell proliferation, differentiation, migration and embryonic development. Importantly, dysregulation of this pathway is tightly associated with pathogenesis in most human cancers. Therefore, the Wnt/β-catenin pathway has emerged as a promising target in anticancer drug screening programs. In the present study, we have isolated three previously unreported metabolites from an undescribed sponge, a species of Monanchora (Order Poecilosclerida, Family Crambidae), closely related to the northeastern Pacific species Monanchora pulchra, collected from deep waters off the Aleutian Islands of Alaska. Through an assortment of NMR, MS, ECD, computational chemical shifts calculation, and DP4, chemical structures of these metabolites have been characterized as spirocyclic ring-containing sesterterpenoid (1) and cholestane-type steroidal analogues (2 and 3). These compounds exhibited the inhibition of β-catenin response transcription (CRT) through the promotion of β-catenin degradation, which was in part implicated in the antiproliferative activity against two CRT-positive colon cancer cell lines.
Hand range interface: information always at hand with a body-centric mid-air input surface

Most interfaces of our interactive devices such as phones and laptops are flat and are built as external devices in our environment, disconnected from our bodies. Therefore, we need to carry them with us in our pocket or in a bag and accommodate our bodies to their design by sitting at a desk or holding the device in our hand. We propose Hand Range Interface, an input surface that is always at our fingertips. This body-centric interface is a semi-sphere attached to a user's wrist, with a radius the same as the distance from the wrist to the index finger. We prototyped the concept in virtual reality and conducted a user study with a pointing task. The input surface can be designed as rotating with the wrist or fixed relative to the wrist. We evaluated and compared participants' subjective physical comfort level, pointing speed and pointing accuracy on the interface that was divided into 64 regions. We found that the interface whose orientation was fixed had a much better performance, with 41.2% higher average comfort score, 40.6% shorter average pointing time and 34.5% lower average error. Our results revealed interesting insights on user performance and preference of different regions on the interface. We concluded with a set of guidelines for future designers and developers on how to develop this type of new body-centric input surface.
Endometrial transcript profile of progesterone‐regulated genes during early pregnancy of Water Buffalo (Bubalus bubalis)

Progesterone (P4 ) plays a key role in the establishment and maintenance of pregnancy in most mammals. Unravelling the expression of progesterone-regulated genes can expand the understanding of the embryonic mortality. Accordingly, we studied the relative mRNA expression of the P4 -regulated genes in the buffalo. Uteri were collected from the abattoir and categorized into nonpregnant late luteal phase, stage I (28-38th days of gestation) and stage II (48-56th days of gestation) of pregnancy (n = 6/group). After extraction of total RNA from the endometrial tissues, we carried out qRT-PCR for determining the relative mRNA expression of the P4 -regulated genes using nonpregnant late luteal phase as calibrator group. The expression of LGALS3BP (essential for maternal recognition of pregnancy) gene was found to be significantly upregulated (p < 0.05), while MUC1 (important for embryo attachment) gene was downregulated in stage I and II of pregnancy. We observed no significant change in the expression of LGALS1, LGALS9 and CTSL genes. The SLC5A11 and SLC2A1 genes (involved in the transport of glucose to endometrium) in early pregnancy were upregulated in the pregnancy stage I (p < 0.05) relative to nonpregnant late luteal phase. The CST3 gene was significantly upregulated in pregnancy stage II (p < 0.01). These results provide molecular insights into the specific pathways involved in foeto-maternal communication during early pregnancy in buffaloes.
Buffering gene expression noise by microRNA based feedforward regulation

Cells use various regulatory motifs, including feedforward loops, to control the intrinsic noise that arises in gene expression at low copy numbers. Here we study one such system, which is broadly inspired by the interaction between an mRNA molecule and an antagonistic microRNA molecule encoded by the same gene. The two reaction species are synchronously produced, individually degraded, and the second species (microRNA) exerts an antagonistic pressure on the first species (mRNA). Using linear-noise approximation, we show that the noise in the first species, which we quantify by the Fano factor, is sub-Poissonian, and exhibits a nonmonotonic response both to the species lifetime ratio and to the strength of the antagonistic interaction. Additionally, we use the Chemical Reaction Network Theory to prove that the first species distribution is Poissonian if the first species is much more stable than the second. Finally, we identify a special parametric regime, supporting a broad range of behaviour, in which the distribution can be analytically described in terms of the confluent hypergeometric limit function. We verify our analysis against large-scale kinetic Monte Carlo simulations. Our results indicate that, subject to specific physiological constraints, optimal parameter values can be found within the mRNA-microRNA motif that can benefit the cell by lowering the gene-expression noise.
Intercolony variations in movement patterns and foraging behaviors among herring gulls (Larus argentatus) breeding in the eastern Wadden Sea

Abstract Herring gulls (Larus argentatus) are opportunistic predators that prefer to forage in the intertidal zone, but an increasing degree of terrestrial foraging has recently been observed. We therefore aimed to analyze the factors influencing foraging behavior and diet composition in the German Wadden Sea. Gulls from three breeding colonies on islands at different distances from the mainland were equipped with GPS data loggers during the incubation seasons in 2012–2015. Logger data were analyzed for 37 individuals, including 1,115 foraging trips. Herring gulls breeding on the island furthest from the mainland had shorter trips (mean total distance = 12.3 km; mean maximum distance = 4.2 km) and preferred to feed on the tidal flats close to the colony, mainly feeding on common cockles (Cerastoderma edule) and shore crabs (Carcinus maenas). In contrast, herring gulls breeding close to the mainland carried out trips with a mean total distance of 26.7 km (mean maximum distance = 9.2 km). These gulls fed on the neobiotic razor clams (Ensis leei) in the intertidal zone, and a larger proportion of time was spent in distant terrestrial habitats on the mainland, feeding on earthworms. δ 13C and δ 15N values were higher at the colony furthest from the mainland and confirmed a geographical gradient in foraging strategy. Analyses of logger data, pellets, and stable isotopes revealed that herring gulls preferred to forage in intertidal habitats close to the breeding colony, but shifted to terrestrial habitats on the mainland as the tide rose and during the daytime. Reduced prey availability in the vicinity of the breeding colony might force herring gulls to switch to feed on razor clams in the intertidal zone or to use distant terrestrial habitats. Herring gulls may thus act as an indicator for the state of the intertidal system close to their breeding colony.
Improving interactive reinforcement learning: What makes a good teacher?

ABSTRACT Interactive reinforcement learning (IRL) has become an important apprenticeship approach to speed up convergence in classic reinforcement learning (RL) problems. In this regard, a variant of IRL is policy shaping which uses a parent-like trainer to propose the next action to be performed and by doing so reduces the search space by advice. On some occasions, the trainer may be another artificial agent which in turn was trained using RL methods to afterward becoming an advisor for other learner-agents. In this work, we analyse internal representations and characteristics of artificial agents to determine which agent may outperform others to become a better trainer-agent. Using a polymath agent, as compared to a specialist agent, an advisor leads to a larger reward and faster convergence of the reward signal and also to a more stable behaviour in terms of the state visit frequency of the learner-agents. Moreover, we analyse system interaction parameters in order to determine how influential they are in the apprenticeship process, where the consistency of feedback is much more relevant when dealing with different learner obedience parameters.
Iterative scatter correction for grid-less skeletal radiography allows improved image quality equal to an antiscatter grid in adjunct with dose reduction: a visual grading study of 20 body donors

Background Iterative scatter correction (ISC) is a new technique applicable to plain radiography; comparable to iterative reconstruction for computed tomography, it promises dose reduction and image quality improvement. ISC for bedside chest X-rays has been applied and evaluated for some time and has recently been commercially offered for plain skeletal radiography. Purpose To analyze the potential of ISC for plain skeletal radiography with regard to image quality improvement, dose reduction, and replacement for an antiscatter grid. Material and Methods A total of 385 radiographs with different imaging protocols of the pelvis and cervical spine were acquired from 20 body donors. Radiographs were rated by four radiologists. Ratings were analyzed with visual grading characteristics (VGC) analysis. The area under the VGC curve was used as a measure of difference in image quality. Results Without ISC, the grid-less images were rated significantly worse than their grid-based counterparts (0.389, P = 0.005); adding ISC made image quality equal (0.498; P = 0.963). In grid-less imaging, reduction of dose by 50% led to significant image quality impairment (0.415, P = 0.001); this was fully counterbalanced when ISC was added (0.512; P = 0.588). Conclusion ISC for plain skeletal radiography has the ability to replace the antiscatter grid without image quality impairment, to improve image quality in grid-less imaging, and to reduce patient radiation dose by 50% without substantial loss in image quality.
Tracking Modified Vaccinia Virus Ankara in the Chicken Embryo: In Vivo Tropism and Pathogenesis of Egg Infections

The Modified Vaccinia virus Ankara (MVA) is a highly attenuated vaccinia virus serving as a promising vector vaccine platform to develop vaccines against infectious diseases. In contrast to the well-established replication deficiency and safety of MVA in mammals, much less is known about MVA infection in avian hosts. Here, we used a recombinant MVA expressing fluorescent reporter proteins under transcriptional control of specific viral early and late promoters to study in vivo tropism, distribution, and pathogenesis of MVA infections in embryonated chicken eggs. The chorioallantoic membrane (CAM) of embryonated chicken eggs was inoculated with recombinant MVA, MVA or phosphate-buffered saline. The infection was analyzed by fluorescence microscopy, histology, immunohistochemistry, and virus titration of embryonic tissues. After infection of the CAM, MVA spread to internal and external embryonic tissues with the liver as a major target organ. Macrophages and hematopoietic cells were identified as primary target cells of MVA infection and may be involved in virus spread. Increasing doses of MVA did not result in increased lesion severity or embryonic death. Despite MVA generalization to embryonic tissues, the CAM seems to be the major site of MVA replication. The absence of considerable organ lesions and MVA-associated mortality highlights an excellent safety profile of MVA in chicken hosts.
Studying appraisal-driven emotion processes: taking stock and moving to the future

ABSTRACT Appraisal theories of emotion, and particularly the Component Process Model, have claimed over the past three decades that the different components of the emotion process (action tendencies, physiological reactions, expressions, and feeling experiences) are essentially driven by the results of multi-level cognitive appraisals and that the feeling component constitutes a central integration and representation of these processes. Given the complexity of the proposed architecture of emotion generation, comprehensive experimental tests of these predictions are difficult to perform and thus evidence has been slow to appear. Complementing earlier work on self-reported appraisal, a massive amount of empirical results from studies with experimental designs based on appraisal manipulation, using electroencephalographic and electromyographic measures, now confirms many of the theoretical predictions with respect to the effect of different appraisal checks, their interactions, and their exact timing. A major issue for future research is the nature of the coherence or synchronisation of the appraisal-driven components in the unfolding emotion process. It is suggested that interdisciplinary multi-team research will be needed to face the theoretical and methodological challenges of experimentally investigating the dynamics of the emotion process.
AutoFrame: Automatic Frame Inference for Object-Oriented Languages

Automatic program verification has made tremendous strides, but is not yet for the masses. How do we make it less painful? This article addresses one of the obstacles: the need to specify explicit "frame clauses", expressing what properties are left unchanged by an operation. It is fair enough to ask the would-be (human) prover to state what each operation changes, and how, but the (mechanical) prover also requires knowledge of what it does not change. The process of specifying and verifying these properties is tedious and error-prone, and must be repeated whenever the software evolves. it is also hard to justify, since all the information about what the code changes is in the code itself. The AutoFrame tool presented here performs this analysis entirely automatically. It applies to object-oriented programming, where the issue is compounded by aliasing: if x is aliased to y, any update to x.a also affects y.a, even though the updating instruction usually does not even mention y. This aspect turns out to be the most delicate, and is addressed in AutoFrame by taking advantage of a companion tool, AutoAlias, which performs sound and sufficiently precise alias analysis, also in an entirely automatic way. Some practical results of AutoFrame so far are: (1) the automatic reconstruction (in about 25 seconds on an ordinary laptop) of the exact frame clauses, a total of 169 clauses, for an 8,000-line data structures and algorithms library which was previously (with the manually written frame clauses) verified for functional correctness using a mechanical program prover; and (2) the automatic generation (in less than 4 minutes) of frame conditions for a 150,000-line graphical and GUI library. The source code of AutoFrame and these examples are available for download.
An Auto-Encoder Matching Model for Learning Utterance-Level Semantic Dependency in Dialogue Generation

Generating semantically coherent responses is still a major challenge in dialogue generation. Different from conventional text generation tasks, the mapping between inputs and responses in conversations is more complicated, which highly demands the understanding of utterance-level semantic dependency, a relation between the whole meanings of inputs and outputs. To address this problem, we propose an Auto-Encoder Matching (AEM) model to learn such dependency. The model contains two auto-encoders and one mapping module. The auto-encoders learn the semantic representations of inputs and responses, and the mapping module learns to connect the utterance-level representations. Experimental results from automatic and human evaluations demonstrate that our model is capable of generating responses of high coherence and fluency compared to baseline models.
Investigating controller less input methods for smartphone based virtual reality platforms

With the advent of the low-cost headsets, Virtual Reality (VR) applications have gained enormous attention and popularity. Object selection is the primary task in VR interfaces. Although numerous studies have been done for the selection of objects, there is limited understanding of how the input methods affect the object selection in sparse, dense and occluded dense Virtual Environment (VE). In this paper, we investigate the commonly used input methods (capacitive touch and dwell gaze) for a smartphone-based VR head-mounted device. We evaluate the task completion time, error rates, ease of use, comfort and user preference correlated to the proposed VEs. The results indicated that capacitive touch was a preferred method of selection in dense and occluded dense VEs. The users preferred dwell gaze in the sparsely populated VE.
A Computing Model of Selective Attention for Service Robot Based on Spatial Data Fusion

Robots and humans are facing the same problem: they all need to face a lot of perceptual information and choose valuable information. Before the robots provide services, they need to complete a robust real-time selective attention process in the domestic environment. Visual attention mechanism is an important part of human perception, which enables humans to select the visual focus on the most potential interesting information. It also could dominate the allocation of computing resource. It also could focus human’s attention on valuable objects in the home environment. Therefore we are trying to transfer visual attention selection mechanism to the scene analysis of service robots. This will greatly improve the robot’s efficiency in perception and processing information. We proposed a computing model of selective attention which is biologically inspired by visual attention mechanism, which aims at predicting focus of attention (FOA) in a domestic environment. Both static features and dynamic features are composed in attention selection computing process. Information from sensor networks is transformed and incorporated into the model. FOA is selected based on a winner-take-all (WTA) network and rotated by inhibition of return (IOR) principle. The experimental results showed that this approach is robust to the partial occlusions, scale-change illumination, and variations. The result demonstrates the effectiveness of this approach with available literature on biological evidence. Some specific domestic service tasks are also tailored to this model.