Miracle-dz/UniFAR-FTUs huggingface dataset:
Backside Protection for Wendelstein 7-X In-Vessel Components

Successful physical experiment campaigns have been performed on the most advanced modular stellarator Wendelstein 7-X (W7-X) during the second operation phase (OP1.2). The completion phase (CP2) lasting until 2021 is devoted to the installation of cryo-vacuum pumps (CVPs), new diagnostics, and actively cooled in-vessel components instead of the inertially cooled ones used in OP1.2. This update allows us to move forward to achieve the steady state operation during the next operation phase (OP2). Several first wall components which are exposed to heat flux in the range from 250 to 500 kW/m2 are covered by graphite tiles facing the plasma. Due to construction constraints, the backside area of the graphite tiles is not fully covered by the actively cooled CuCrZr heat sinks. This results in the presence of high-temperature graphite rims, which become an additional heat radiation source for the components behind the first wall. This article presents stepwise development of backside protections (BSPs) to mitigate the problem mentioned above. The process is supported by: 1) the study of BSP shielding performances through thermal analysis taking into account plasma radiation and electron-cyclotron resonance heating (ECRH) loads; 2) BSP sizing restricted by electromagnetic forces during main coil/plasma current decay; and 3) mechanical analysis to confirm the structural fixation of BSP. In addition, several analysis iterations for CVP have been repeated to minimize BSP cost by identification of first wall components with minor heat radiation to the CVP and marginal influence on its cooling system capacity.
Episodic Lithospheric Deformation in Eastern Tibet Inferred From Seismic Anisotropy

Mechanisms for uplift and deformation of the Tibetan Plateau remain vigorously debated; hypotheses include stepwise growth, distributed thickening, and crustal channel flow, each with a distinct anisotropic signature. We have developed a new azimuthally anisotropic shear velocity model for the lithosphere beneath eastern Tibet, based on ambient noise tomography from 643 seismic stations. In our model, the Tibetan upper crust is characterized by strong anisotropy with fast axes that correlate with surface geology and mantle anisotropy, suggesting the occurrence of coherent deformation. However, a much different picture emerges in the middle and lower crust, where anisotropy is disordered and weaker beneath the plateau than along its margins, inconsistent with the prediction of large‐scale eastward crust flow in eastern Tibet. Our observations are best explained by heterogeneous crustal thickening beneath the plateau with complex flow in the middle and lower crust, accompanied by asthenospheric upwelling along the southeastern plateau margin.
VALIDATION OF THE CHILD –ORAL IMPACTS ON DAILY PERFORMANCES QUESTIONNAIRE AMONG GROUP OF11-12YEAR-OLD EGYPTIAN CHILDREN

INTRODUCTION: Oral health related quality of life measure has a great importance at all levels of dental research, it helps to plan evidence based public health policies and indicates how resource allocation should be done. OBJECTIVES: The aim of this study was to assess the Child-OIDPQ reliability and validity for application among Egyptian children aged 11-12-year-old, as well as determining the prevalence and causes of oral impacts on daily performances in public and private school children in Alexandria. MATERIALS AND METHODS: Cross-sectional survey performed on 410 randomly selected student aged 11–12 years in the middle district of Alexandria city, Egypt. Data were collected through a self-administered questionnaire; Child-Oral Impacts on Daily Performances questionnaire (Child-OIDP). RESULTS: The instrument showed acceptable psychometric properties and is considered as a valid, reliable and practical inventory for use among the Egyptian sample. (Cronbach's alpha 0.71 for severity and 0. 70 for frequency). The prevalence of oral impacts was high (85.4 %) of children experiencing some kind of oral conditions affecting their daily life during the past three months. The highest impact was reported on eating (61.9%) followed by cleaning (46.3%) and the lowest impact was on speaking (21.0%). Tooth pain was one of the main perceived causes of impacts on the following 5 performances: duties (35.9%), emotional status (11.1%), sleeping (42.2%), eating (32.0%) and speaking (16.7%). there was no statistically significant difference detected by Mont Carlo exact probability test in the intensity effect of impact between public and private schools CONCLUSIONS: It was concluded that the Child-OIDP questionnaire can be applied to Egyptian children as a valid measure of oral health related quality of life.
A Framework for Clinical Practice With Sexual and Gender Minority Asylum Seekers

In many countries around the world, sexual and gender minority individuals experience gross human rights violations and therefore must conceal their identities to survive. Without adequate protections, these individuals are forced to flee to countries such as the United States and Canada. By the time sexual and gender minority asylum seekers (SGMAS) arrive in these countries, they may suffer from depression, posttraumatic stress disorder, and complex trauma. SGMAS may struggle with these mental health problems while also attempting to navigate the difficulties of migration (e.g., locating housing and employment, filing an asylum claim). The extant literature on refugee and sexual and gender minority populations, however, may not provide adequate guidance to therapists who assist SGMAS. Therefore, this article presents a framework for clinical practice with SGMAS. This framework is informed by research on complex trauma, minority stress, acculturation/integration, and resilience. The 3 components of the framework are establishing safety and stability in treatment and in the environment, developing skills for managing the asylum claims process, and providing strategies for dealing with the challenges of resettlement. These components are intended to help clients to heal from trauma, handle the demands of acculturation, and cope with minority stress.
A virus-encoded protein suppresses methylation of the viral genome in the Cajal body through its interaction with AGO4

In plants, establishment ofde novoDNA methylation is regulated by the RNA-directed DNA methylation (RdDM) pathway. RdDM machinery is known to concentrate in the Cajal body, but the biological significance of this localization has remained elusive. Here, we show that the anti-viral methylation of theTomato yellow leaf curl virus(TYLCV) genome occurs specifically in the Cajal body ofNicotiana benthamianacells. Methylation of the viral genome is countered by a virus-encoded protein, V2, which interacts with the central RdDM component AGO4, interfering with its binding to the viral DNA; Cajal body localization of the V2-AGO4 interaction is required for the viral protein to exert this function. Taken together, our results draw a long sought-after functional connection between RdDM, the Cajal body, and anti-viral DNA methylation, paving the way for a deeper understanding of DNA methylation and anti-viral defences in plants.
Trends, motivations and experiences of Czech migrant nurses : a mixed methods study

The migration of nurses is currently an important political theme, and it is only expected to intensify in the future, because of the current demographic trends. Considering the facilitating policies and the differences between salaries, the intra-European migration of nurses is rather small, but its monitoring is not very exact. The migration of Czech general care nurses remains under-researched. I used mixed research with explorative sequential design in this study. In the initial embedded qualitative strand, I interviewed informants with expert knowledge on the migration of Czech nurses. The second quantitative strand consisted of a survey of self-selected Czech migrating nurses using an electronic questionnaire. The last strand used a focus group technique with Czech nursing migrants to clarify some of the previously researched topics. Some findings from this study are similar to the previously conducted research, and some differ substantially. Almost all of the respondents and participants felt that their professional skills improved because of their migration. More than half eventually returned to the Czech Republic, often they provided direct care in the Czech Republic, and mostly they reported not being able to utilize all of the new knowledge gained abroad. The main destination country was Saudi Arabia, therefore the respondents often cooperated with a recruiting agency. Their families were typically not involved in the decision to migrate and the migrants only rarely sent remittances home. Instead, they invested their earnings in real estate. Consistent with the literature, the professional communication in a foreign language and the different nursing practices of the destination country were rated as difficult. Findings from all three strands suggested that the nurses were transformed by the migration. It is generally understood that nurses are vital for providing health care services, thus we should offer them motivating working conditions to prevent more extensive migration and use the potential of brain circulation.
Object Selection by Automatic Spreading of Top-Down Attentional Signals in V1

What is selected when attention is directed to a specific location of the visual field? Theories of object-based attention have suggested that when spatial attention is directed to part of an object, attention does not simply enhance the attended location but automatically spreads to enhance all locations that comprise the object. Here, we tested this hypothesis by reconstructing the distribution of attention from primary visual cortex (V1) population neuronal activity patterns in 24 human adults (17 female) using functional magnetic resonance imaging (fMRI) and population-based receptive field (prf) mapping. We find that attention spreads from a spatially cued location to the underlying object, and enhances all spatial locations that comprise the object. Importantly, this spreading was also evident when the object was not task relevant. These data suggest that attentional selection automatically operates at an object level, facilitating the reconstruction of coherent objects from fragmented representations in early visual cortex. SIGNIFICANCE STATEMENT Object perception is an astonishing feat of the visual system. When visual information about orientation, shape, and color enters through our eyes, it has yet to be integrated into a coherent representation of an object. But which visual features constitute a single object and which features belong to the background? The brain mechanisms underpinning object perception are yet to be understood. We now demonstrate that one candidate mechanism, the successive activation of all parts of an object, occurs in early visual cortex and results in a detailed representation of the object following Gestalt principles. Furthermore, our results suggest that object selection occurs automatically, without involving voluntary control.
New species and new records of Sciophila Meigen (Diptera: Mycetophilidae) from the Afrotropical region.

A comprehensive material of Afrotropical Sciophila including 262 male specimens of 15 species collected from 7 countries are studied. Two new species-S. geiri sp. n. and S. tchabalensis sp. n. -are described from Madagascar and Cameroon, respectively. New records of the following 13 species are presented: S. digitilenta Søli, 1997 (Uganda), S. fenestralis Søli, 1997 (South Africa), S. kakumensis Søli, 1997 (Cameroon, Uganda), S. kjaerandseni Søli, 1997 (Uganda), S. koundensis Søli, 1997 (Uganda), S. leptosoma Søli, 1997 (Democratic Republic of Congo), S. longistyla Søli, 1997 (South Africa), S. mazumbaiensis Søli, 1997 (Uganda), S. ocreata Philippi, 1865 (France: La Réunion), S. papula Søli, 1997 (Democratic Republic of Congo), S. pinniger Søli, 1997 (South Africa, Cameroon, Uganda, Kenya), S. quadra Søli, 1997 (Democratic Republic of Congo), S. stellata Søli, 1997 (Uganda). The majority of the new records represent the first ones since initial description of the species. S. ocreata is considered to be introduced to the Island of La Réunion. The number of Afrotropical Sciophila species is set at 23.
Automating dictionary production: a Tagalog-English-Korean dictionary from scratch

In this paper we present lexicographic work on a Tagalog-English-Korean dictionary. The dictionary is created entirely from scratch and all of its content (besides audio pronunciation) is initially generated fully automatically from a large web corpus that we built for these purposes, and then post-edited by human editors. The full size of the dictionary is 45,000 entries, out of which 15,000 most frequent entries are manually post-edited, while the remaining 30,000 entries are left only as automated. The project is currently ongoing and will be finished in December 2019. The dictionary will be part of the online platform run by the Naver Corporation1 and freely available.
Computing Quality of Navigation Designed into a WEB-Site

People around the world are at web sites for want of information, doing shopping, conduct literature surveys, gain knowledge, post activities and actions, do chatting, develop communities, and organize events and many such purposes. A vast number of websites are in use for information dissemination. It has become difficult to figure the web site where the information is available for which the user is looking. The search engine invented and implemented to help the user to locate the website where the information is available desired by the users. One of the most critical aspects of extensive usage of the web site is the navigation implemented within the development of web sites. People must be able to navigate across the web sites with ease and land up at the location where the information posted. Users get satisfied when the information that they are looking for is available with ease and within the negligible amount of time. Many factors influence the quality of a web site out, which the factor “Navigation” is the key as it forms the backbone of any web site. If the web sites poorly designed, it leads to the implementation of poor navigation, and the user usually tends to ignore surfing such a website. Some contributions exist in the literature relating the definition and meaning of the factor “Navigation,” but no formal methods, techniques, frameworks exist used for computing the quality of the website. An approach / Model presented in this paper for computing quality of a web site considering “Navigation” of the website as the primary focus
Application Phase Behavior-Guided Thermal Management of Embedded Platforms

This letter presents a scheduling policy for multicore embedded applications based on their thermal phase behavior. The thermal phase-guided task allocation allows the scheduler to allocate tasks that run at elevated temperature to low-power cores while others running at normal temperature to high performing cores. The proposed phase-based thermal aware technique shows 15.4 °C reduction in average temperature and 30.5 °C in peak temperature when experimented with PARSEC benchmark applications targeted on the ODROID XU4 embedded platform.
Autonomy, Integrity, and Values in Public Administration: A Dilemma and a Case

This article addresses a classic problem of public administration, which is the quest for institutional integrity in the presence of bureaucratic autonomy. It does so in combination with a history of ideas account of the subject with a case study of derailed autonomy at the expense of institutional integrity It does so in combination with a history of ideas account of the subject with a case study of derailed autonomy at the expense of institutional integrity with particularly serious consequences in the form of human casualties. Referring to literature on public values and moral hazard under the condition of bureaucratic discretion, the article argues that harmonizing bureaucratic autonomy and institutional integrity requires commitment to public values that prioritize the protection of basic individual rights over temptations of pragmatic decision making. It is, therefore, a plea for linking traditional lines of thoughts on public administration with a more fine-grained assessment of the ambivalence of governmental agencies as both guardians of, and a menace to, rule-of-law-based protection of civic values.
Effect of Various Invitation Schemes on the Use of Fecal Immunochemical Tests for Colorectal Cancer Screening: Protocol for a Randomized Controlled Trial

Background Fecal occult blood testing has been offered for many years in the German health care system, but participation rates have been notoriously low. Objective The aim of this study is to evaluate the effect of various personal invitation schemes on the use of fecal immunochemical tests (FITs) in persons aged 50-54 years. Methods This study consists of a three-armed randomized controlled trial: (1) arm A: an invitation letter from a health insurance plan including a FIT test kit, (2) arm B: an invitation letter from a health insurance plan including an offer to receive a free FIT test kit by mail upon easy-to-handle request (ie, by internet, fax, or reply mail), and (3) arm C: an information letter on an existing colonoscopy offer (ie, control). Within arms A and B, a random selection of 50% of the study population will receive reminder letters, the effects of which are to be evaluated in a substudy. Results A total of 17,532 persons aged 50-54 years in a statutory health insurance plan in the southwest of Germany—AOK Baden-Wuerttemberg—were sent an initial invitation, and 5825 reminder letters were sent out. The primary end point is FIT usage within 1 year from receipt of invitation or information letter. The main secondary end points include gender-specific FIT usage within 1 year, rates of positive test results, rates of colonoscopies following a positive test result, and detection rates of advanced neoplasms. The study was launched in September 2017. Data collection and workup were completed in fall 2019. Conclusions This randomized controlled trial will provide important empirical evidence for enhancing colorectal cancer screening offers in the German health care system. Trial Registration German Clinical Trials Register (DRKS) DRKS00011858; https://bit.ly/2UBTIdt International Registered Report Identifier (IRRID) DERR1-10.2196/16413
The Neurobiology of Panic: A Chronic Stress Disorder

Panic disorder is an often chronic and impairing human anxiety syndrome, which frequently results in serious psychiatric and medical comorbidities. Although, to date, there have been many advances in the diagnosis and treatment of panic disorder, its pathophysiology still remains to be elucidated. In this review, recent evidence for a neurobiological basis of panic disorder is reviewed with particular attention to risk factors such as genetic vulnerability, chronic stress, and temperament. In addition, neuroimaging data are reviewed which provides support for the concept of panic disorder as a fear network disorder. The potential impact of the National Institute of Mental Health Research Domain Criteria constructs of acute and chronic threats responses and their implications for the neurobiology of panic disorder are also discussed.
Trastuzumab Resistance: What Are We Offering to Breast Cancer Patients?

Human epidermal growth factor receptor-2 (HER2/ErbB-2) is a receptor tyrosine kinase involved in cell growth and differentiation and over-expressed in about 15-30% of breast cancers. Trastuzumab is an anti-HER2 monoclonal antibody that has significantly improved survival of patients with early and metastatic breast cancer (BC). However, 65% patients experience primary and secondary resistance. This article explores existing and emerging combination therapy for HER2 positive breast cancer, highlighting the success of trastuzumab in combination with another monoclonal antibody, pertuzumab and small molecule tyrosine kinase inhibitors lapatinib and neratinib. Recent studies have indicated that combination of trastuzumab, pertuzumab and lapatinib increases the 3-year overall survival from 90% to 95% in metastatic BC patients. The EPHOS-B trial has shown a remarkable shrinkage of the tumour when lapatinib is used before surgery and chemotherapy. Despite this success, pertuzumab has just been approved for use in the British National Health Service (NHS) while pertuzuamb, lapatinib and neratinib have been approved for European and American markets for a number of years. Lapatinib and neratinib are not available yet in UK. Strict assessment criteria on cost-benefits might limit the access to these drugs to British cancer patients.
INFLUENCE OF BIAFRA-RELATED SOCIAL MEDIA CONTENTS ON THE ACCEPTANCE OF IPOB AGENDA IN SOUTH-EAST NIGERIA

Improvement in internet capacity had led to the creation of various social media platforms. The various social media platforms influenced how individuals, groups and communities interacted with each other and events in their environment. Therefore, this study examined the influence of social media contents of agitators and secescionists on consumers of such contents and how the contents influenced their perception of the struggle with focus on Biafra related contents through qualitative study. The study adopted focus group discussion to gather data using a combination of Constant Comparison Analysis (CCA) and Micro-Interlocutor Analysis to analyse the data. Participants in the study were selected using purposive sampling to assemble four cohorts with each cohort having homogeneous features except age. The study found out that consumers of Biafra social media contents, apart from interacting with the contents, also interrogate the contents. The study also found out that consumers of social media contents who were supporters of the secessionist group rely on perceived beliefs to argue in support of the veracity of the consumed contents even if there had been facts to argue against the authenticity of such contents. The study concluded that social media reinforce perceived beliefs through consumed contents.