Miracle-dz/UniFAR-FTUs huggingface dataset:
Electronic Supporting Information Single Quantum Dot-Based Nanosensor for Rapid and Sensitive Detection of Terminal Deoxynucleotidyl Transferase

Electronic Supporting Information Single Quantum Dot-Based Nanosensor for Rapid and Sensitive Detection of Terminal Deoxynucleotidyl Transferase Li-Juan Wang,a, † Ming-Li Luo,a, † Qianyi Zhang, b, † Bo Tang,a, * and Chun-Yang Zhang a, * a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, P. R. China b Nantou High School Shenzhen, Shenzhen, 518052, China † These authors contributed equally * To whom correspondence should be addressed. E-mail: cyzhang@sdnu.edu. cn; tangbo@sdnu.edu. cn
Roll-to-roll embedded conductive structures integrated into organic photovoltaic devices

Highly conductive screen printed metallic (silver) structures (current collecting grids) combined with poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) are a viable replacement for indium tin oxide (ITO) and inkjet printed silver as transparent electrode materials. To provide successful integration into organic photovoltaic (OPV) devices, screen printed silver current collecting grids should be embedded into a substrate to avoid topology issues. In this study micron-thick conductive structures are embedded and integrated into OPV devices. The embedded structures are produced roll-to-roll with optimized process settings and materials. Topology measurements show that the embedded grids are well suited for integration into OPV devices since the surface is almost without spikes and has low surface roughness. JV measurements of OPV devices with embedded structures on a polyethylene terephthalate/silicon nitride (PET/SiN) substrate show an efficiency of 2.15%, which is significantly higher than identical flexible devices with ITO (1.02%) and inkjet printed silver (1.48%). The use of embedded screen printed silver instead of ITO and inkjet printed silver in OPV devices will allow for higher efficiency devices which can be produced with larger design and process freedom.
Enabling electromechanical transduction in silicon nanowire mechanical resonators fabricated by focused ion beam implantation

We present the fabrication of silicon nanowire (SiNW) mechanical resonators by a resistless process based on focused ion beam local gallium implantation, selective silicon etching and diffusive boron doping. Suspended, doubly clamped SiNWs fabricated by this process presents a good electrical conductivity which enables the electrical read-out of the SiNW oscillation. During the fabrication process, gallium implantation induces the amorphization of silicon that, together with the incorporation of gallium into the irradiated volume, increases the electrical resistivity to values higher than 3 Ω m, resulting in an unacceptably high resistance for electrical transduction. We show that the conductivity of the SiNWs can be restored by performing a high temperature doping process, which allows us to recover the crystalline structure of the silicon and to achieve a controlled resistivity of the structures. Raman spectroscopy and TEM microscopy are used to characterize the recovery of crystallinity, while electrical measurements show a resistivity of 10−4 Ω m. This resistivity allows to obtain excellent electromechanical transduction, which is employed to characterize the high frequency mechanical response by electrical methods.
Interplay of hydrogen treatment and nitrogen doping in ZnO nanoparticles: a first-principles study

With the help of density functional calculations using the HSE and PBE functionals, it is shown that incorporation of nitrogen into ZnO nanoparticles is energetically less costly compared to ZnO bulk, due to charge transfer between Zn dangling bonds and the NO impurity. Neutral NO results after full passivation of the doped nanoparticles by a treatment with atomic hydrogen. A nanocomposite made from such ZnO particles could show thermally activated p-type hopping conductivity.
Symptom Profiles in Individuals Aging with Post‐Polio Syndrome

nocturia, although this cutoff should be explored in larger study populations to be validated. In addition, the use of incontinence material is not only based on the presence of urinary incontinence. The results show that the presence and frequency of nocturnal incontinence was significantly higher in the group wearing incontinence material, as expected, but four residents reported that they do not experience urinary incontinence despite the use of incontinence material. These residents are subject to comorbidities and poor mobility necessitating the use of incontinence material as continence policy. The results of the SF-36 questionnaire, on which significantly lower scores concerning physical and emotional functioning and pain were found in the group wearing incontinence material, also reflect this. New or worsening incontinence even in frail, functionally and cognitively impaired nursing home residents seriously decreases quality of life. Reducing nocturnal urine volume might improve quality of life in the subgroup of individuals wearing incontinence material because of nocturnal incontinence by reducing the need for incontinence material.
Implant-associated local drug delivery systems for different medical applications

In recent years novel implants in particular have already proven to contribute substantially to enhanced quality of life, higher efficacy of therapeutic approaches, as well as patient safety. With the purpose to optimize the implant-tissue in- teraction the focus of efforts is on implants with a controlled, site-selective drug release. Therefore, we develop within the REMEDIS consortium implant-associated local drug delivery (LDD) systems for different medical applications. En- gineering and natural scientists together with medical experts from all over Germany work in close collaboration to develop such innovative implants which combine the function as medical device and as LDD system. These include vascular stents and stimulation electrodes for the circulatory system and the ears, glaucoma stents for the eyes as well as auditory tube stents for the ears. Through its efforts to combine a LDD system into the functionality of implants, REMEDIS provides cutting-edge re- search into such medical technology.
Pre‐admission clinics in day surgery. The ‘one‐stop shop’: tools and methods for practice improvement and service development

The improvement of services aligned to day surgery is a still prominent topic in government policy debates and an important development area for many NHS trusts. This article attempts to describe the emergence of the ‘one-stop shop’ approach in surgical outpatients and preoperative assessment clinics. It portrays the ways in which one clinical team moved their ideas forward to develop an integrated, multidisciplinary service, and describes the tools and methods they adopted to cross the borderlands between practice development and service improvement, to enable success. Copyright © 2009 John Wiley & Sons, Ltd.
Quantitative electrostatic force microscopy with sharp silicon tips

Electrostatic force microscopy (EFM) probes are typically coated in either metal (radius ∼ 30 nm) or highly-doped diamond (radius ∼ 100 nm). Highly-doped silicon probes, which offer a sharpened and stable tip apex (radius ∼ 1–10 nm) and are usually used only in standard atomic force microscopy, have been recently shown to allow enhanced lateral resolution in quantitative EFM and its application for dielectric constant measurement. Here we present the theoretical modelling required to quantitatively interpret the electrostatic force between these sharpened tips and samples. In contrast to a sphere-capped cone geometry used to describe metal/diamond-coated tips, modelling a sharpened silicon tip requires a geometry comprised of a cone with two different angles. Theoretical results are supported by experimental measurements of metallic substrates and ∼10 nm radius dielectric nanoparticles. This work is equally applicable to EFM and other electrical scanned probe techniques, where it allows quantifying electrical properties of nanomaterials and 3D nano-objects with higher resolution.
Evaluating the Centers for Disease Control’s Empirical Chronic Fatigue Syndrome Case Definition

The Centers for Disease Control and Prevention (CDC) recently developed an empirical case definition that specifies criteria and instruments to diagnose chronic fatigue syndrome (CFS) in order to bring more methodological rigor to the current CFS case definition. The present study investigated this new definition with 27 participants with a diagnosis of CFS and 37 participants with a diagnosis of a Major Depressive Disorder. Participants completed questionnaires measuring disability, fatigue, and symptoms. Findings indicated that 38% of those with a diagnosis of a Major Depressive Disorder were misclassified as having CFS using the new CDC definition. Given the CDC’s stature and respect in the scientific world, this new definition might be widely used by investigators and clinicians. This might result in the erroneous inclusion of people with primary psychiatric conditions in CFS samples, with detrimental consequences for the interpretation of epidemiologic, etiologic, and treatment efficacy findings for people with CFS.
Controlled coupling of a single nanoparticle in polymeric microstructure by low one-photon absorption—based direct laser writing technique

We investigated the coupling of a single nanoparticle (NP) into a polymer-based photonic structure (PS). The low one-photon absorption microscopy with a two-step technique allowed us first to accurately determine the location of a NP and then to embed it as desired into an arbitrary PS. The coupling of a gold NP and a polymer-based PS was experimentally investigated showing a six-fold photon collection enhancement as compared to that of a NP in unpatterned film. The simulation results based on finite-difference time-domain calculation method confirmed this observation and showed a 2.86-fold enhancement in extraction efficiency thanks to the NP/PS coupling.
Early inhibition of tumor necrosis factor‐α and interleukin‐6 in muscle tissue as a therapy for dystrophinopathy in mdx mice

Pro‐inflammatory cytokines can exacerbate muscle fiber damage in dystrophinopathy. The aim of the present study was to identify cytokine/chemokine alterations in the muscle tissues of mdx mice, a model of dystrophinopathy, and the beneficial effects of anti‐proinflammatory cytokine therapy.
Quantitative sub-surface and non-contact imaging using scanning microwave microscopy

The capability of scanning microwave microscopy for calibrated sub-surface and non-contact capacitance imaging of silicon (Si) samples is quantitatively studied at broadband frequencies ranging from 1 to 20 GHz. Calibrated capacitance images of flat Si test samples with varying dopant density (1015–1019 atoms cm−3) and covered with dielectric thin films of SiO2 (100–400 nm thickness) are measured to demonstrate the sensitivity of scanning microwave microscopy (SMM) for sub-surface imaging. Using standard SMM imaging conditions the dopant areas could still be sensed under a 400 nm thick oxide layer. Non-contact SMM imaging in lift-mode and constant height mode is quantitatively demonstrated on a 50 nm thick SiO2 test pad. The differences between non-contact and contact mode capacitances are studied with respect to the main parameters influencing the imaging contrast, namely the probe tip diameter and the tip–sample distance. Finite element modelling was used to further analyse the influence of the tip radius and the tip–sample distance on the SMM sensitivity. The understanding of how the two key parameters determine the SMM sensitivity and quantitative capacitances represents an important step towards its routine application for non-contact and sub-surface imaging.
Outcome of Adult Respiratory Failure Patients Receiving Prolonged (≥14 Days) ECMO

Objective:To examine the outcomes of prolonged (≥14 days) extracorporeal membrane oxygenation (P-ECMO) for adult severe respiratory failure and to assess characteristics associated with survival. Background:The use of ECMO for treatment of severe respiratory adult patients is associated with overall survival rates of 50% to 70% with median ECMO duration of 10 days. No prior multi-institutional studies have examined outcomes of P-ECMO for severe respiratory failure. Methods:Data on all adult (≥18 years) patients who required P-ECMO for severe respiratory failure from 1989 to 2013 were extracted from the Extracorporeal Life Support Organization international multi-institutional registry. We examined outcomes over 23 years and compared the 2 more recent time periods of 1989 to 2006 versus 2007 to 2013. Results:Up to 974 patients, mean age 40.2 (18–83) years, had ECMO duration of mean 25.2 days/median 21.0 days (range: 14–208 days). Venovenous ECMO support was most common (venovenous: 79.5%, venoarterial: 9.9%). Reason for ECMO discontinuation included native lung recovery (54%), organ failure (23.7%), family request (6.7%), hemorrhage (2.7%), and diagnosis incompatible with life (5.6%). Forty patients (4.1%) underwent lung transplant with 50% postoperative in-hospital mortality. Increased prevalence of P-ECMO was noted with 72% (701/974) of all cases reported since 2008. Survival to hospital discharge was 45.4% (443/974) and did not vary with ECMO duration. Multivariate logistic regression analysis confirmed that P-ECMO patients 2007 to 2013 had a lower risk of death [odds ratio (OR): 0.650; 95% confidence interval (CI), 0.454–0.929; P = 0.010] compared with 1989 to 2006. Factors independently associated with survival were younger age (OR: 0.983; 95% CI, 0.974–0.993; P < 0.001) and lower PaCO2 (OR, 0.991; 95% CI, 0.986–0.996; P < 0.001). Conclusions:Prolonged ECMO use for adult respiratory failure was associated with a lower (45.4%) hospital survival rate, compared with prior reported survival rates of short duration ECMO. Prolonged ECMO survival significantly increased in recent years, and increasing ECMO duration did not alter the survival fraction in the 1989 to 2013 study cohort. Although P-ECMO survival rates are less than short ECMO runs, P-ECMO support is justified.
Ant Colony Algorithm for Just-in-Time Job Shop Scheduling with Transportation Times and Multirobots

Handling rapidly evolving technology and almost daily changes in demand and customer satisfaction, while maintaining competitiveness in a highly competitive environment, requires good coordination and planning of both production and logistics activities on the shop floor, namely: machines and tools. The goal is to optimize costs and reduce delivery lead times in order to provide the customer just in time; we focus on the job shop scheduling problem (JSSP), which is one of the most complex problems encountered in real shop floor. In this paper, we study a generalized (JSSP) including transportation times and a set of additional constraints on the number of transporter vehicles and their multiple transfer capabilities and also on the limited capacity of input/output of machines. The objective is to minimize in one hand tardiness and earliness penalties on delays and advances compared to the lead-time delivery of finished jobs and on the other hand the number of empty moves of transporter vehicles.
Heterogeneity of Ki-67 and p53 Expression in Glioblastoma

Summary Introduction. Heterogeneity is a characteristic feature of malignant tumours. It challenges the treatment regimens as well as can impair the diagnostic accuracy. Glioblastoma multiforme (GBM), a high-grade malignant glial tumour, is known for the extreme morphological heterogeneity giving rise also to the term itself. Aim of the study was to evaluate heterogeneity of pathogenetically and diagnostically important cardinal tumour features, namely, cellular proliferation and tumour suppressor protein expression in GBMs. Material and methods. The study group comprised 101 GBMs, retrospectively identified by archive search. The inclusion criteria comprised validated diagnosis (by World Health Organisation criteria) and lack of prior treatment. Recurrent GBMs as well as other glial and non-glial tumours were excluded from the study. Insufficient tissue materials comprising stereotactic biopsies and tissues affected by widespread necrosis (exceeding 90%) were also excluded. Proliferation activity (by Ki-67) and expression of aberrant p53 protein was detected by immunohistochemical investigation (IHC) of formalin-fixed, paraplast-embedded tumour samples. Polymeric visualisation system was used to detect bound primary antibodies. The expression of each antigen was measured by computed morphometry in at least 200 cells of hot and cold spots in each tumour. The data were expressed as the relative value. Heterogeneity was estimated as the mathematical difference between the highest and lowest expression value in each tumour. Descriptive statistics was applied. The 95% confidence intervals (CI) were determined as well. Results. The highest proliferation activity ranged 15 – 95%; mean 43.9% [95% CI = 40.3 – 47.6]. The lowest proliferation activity ranged 2 – 95%, mean 20.1% [16.8 – 23.4]. The mean proliferation heterogeneity was 23.8% [21.5 – 26.2]; range 0 – 67%. The mean heterogeneity of p53 protein expression was 11.7% [8.9 – 14.6], ranging 0 – 75%. Conclusions. GBM is characterized by marked heterogeneity regarding proliferation rate and expression of p53 protein that may affect diagnostic accuracy and grading of gliomas in small samples of tissue material as well as survival in case of small residual tumour after surgical treatment.
Implications of Multiple Complications on the Postoperative Recovery of General Surgery Patients

Objectives:To evaluate the association between multiple complications and postoperative outcomes and to assess which complications occur together in patients with multiple complications. Background:Patients who suffer multiple complications have increased risk of prolonged hospital stay and mortality. However, little is known about what places patients at risk for multiple complications or which complications tend to occur in these patients. Methods:Surgical patients were identified from the American College of Surgeons National Quality Improvement Program (ACS NSQIP) database from 2005 to 2011. The frequency of postoperative complications was assessed. Patients with less than two complications were compared with patients who had multiple complications using &khgr;2 and logistic regression analysis. Relationships among postoperative complications were explored by learning a Bayesian network model. Results:The study population consisted of 470,108 general surgery patients. The overall complication rate was 15% with multiple complications in 27,032 (6%) patients. Patients with multiple complications had worse postoperative outcomes (P < 0.001). The strongest predictors for developing multiple complications were admission from chronic care facility or nursing home, dependent functional status, and higher American Society of Anesthesiologist Physical Status classification. In patients with multiple complications, the most common complication was sepsis (42%), followed by failure to wean ventilator (31%), and organ space surgical site infection (27%). We found that severe complications were most strongly associated with development of multiple complications. Using a Bayesian network, we were able to identify how strongly associated specific complications were in patients who developed multiple complications. Conclusions:Almost half (40%) of patients with complications suffer multiple complications. Patient factors such as frailty and comorbidity strongly predict the development of multiple complications. The results of our Bayesian analysis identify targets for interventions aimed at disrupting the cascade of multiple complications in high-risk patients.
Preliminary Data from the Caring for Older Adults and Caregivers at Home (COACH) Program: A Care Coordination Program for Home‐Based Dementia Care and Caregiver Support in a Veterans Affairs Medical Center

Caring for Older Adults and Caregivers at Home (COACH) is an innovative care coordination program of the Durham Veteran's Affairs Medical Center in Durham, North Carolina, that provides home‐based dementia care and caregiver support for individuals with dementia and their family caregivers, including attention to behavioral symptoms, functional impairment, and home safety, on a consultation basis. The objectives of this study were to describe the COACH program in its first 2 years of operation, assess alignment of program components with quality measures, report characteristics of program participants, and compare rates of placement outside the home with those of a nontreatment comparison group using a retrospective cohort design. Participants were community‐dwelling individuals with dementia aged 65 and older who received primary care in the medical center's outpatient clinics and their family caregivers, who were enrolled as dyads (n = 133), and a control group of dyads who were referred to the program and met clinical eligibility criteria but did not enroll (n = 29). Measures included alignment with Dementia Management Quality Measures and time to placement outside the home during 12 months of follow‐up after referral to COACH. Results of the evaluation demonstrated that COACH aligns with nine of 10 clinical process measures identified using quality measures and that COACH delivers several other valuable services to enhance care. Mean time to placement outside the home was 29.6 ± 14.3 weeks for both groups (P = .99). The present study demonstrates the successful implementation of a home‐based care coordination intervention for persons with dementia and their family caregivers that is strongly aligned with quality measures.
Ionic compound mediated rearrangement of 3, 4, 9, 10-perylene tetracarboxylic dianhydride molecules on Ag(100) surface

Tailoring of the assembly structure of organic molecular monolayer is of great importance to improve the performance of molecular devices. In this work, a typical ionic compound, namely KCl, was used to mediate the rearrangement of 3, 4, 9, 10-perylene tetracarboxylic dianhydride (PTCDA) monolayer on Ag(100). Combined scanning tunneling microscopy (STM) and low energy electron diffraction (LEED) results indicate that both molecule and molecular superlattice would rotate after the dosing of KCl. The density functional theory calculation shows that KCl would exist in the form of molecules rather than ions on Ag(100) and demonstrates that experimentally observed structural transition induced by KCl molecules is energetically favored.