Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Intraoperative Fentanyl Consumption on Prognosis of Colorectal Liver Metastasis treated by Simultaneous Resection: A Propensity Score Matching Analysis

Background: No previous studies have reported the effect of intraoperative opioid consumption in colorectal liver metastasis (CRLM). Methods: Medical records of patients who received simultaneous resection of CRLM were retrospectively reviewed. Patients with epidural anesthesia, intraoperative morphine, or intraoperative oxycodone were excluded. Patients were separated into high- and low-dose groups by median intraoperative equianalgesic fentanyl dose. Short-term outcomes, progression-free surcical (PFS) and overall survival (OS) were compared between groups before and after 1:1 propensity score matching (PSM). Univariable and multivariable Cox regression analysis were performed to identify independent predictors of survival. Results: The final study population included 343 patients. Patients were separated into the low dose group (n=172) and the high dose group (n=171) by median intraoperative equianalgesic fentanyl dose (8.33 μg/kg). After PSM, 55 patients in the low dose group were matched to 55 patients in the high dose group and the baseline characteristics of the two groups were balanced. The two groups had no statistically significance difference in severity and categories of postoperative complications before and after PSM. Before PSM, the two groups had similar PFS (median 10.2 vs. 12.4 months, P=0.54) and OS (median 59.0 vs. 58.3 months, P=0.76). Univariate and multivariate Cox regression analyses revealed no statistically significant association between intraoperative equianalgesic fentanyl and PFS (multivariate HR=0.852, 95% CI 0.655-1.11, P=0.235) and OS (multivariate HR=1, 95% CI 0.68-1.49, P = 0.981). After PSM, the two groups also had similar PFS (median 9.2 vs. 10.7 months, P=0.98) and OS (median 51.0 vs. 46.0 months, P=0.39). Univariate and multivariate Cox regression analyses revealed no statistically significant association between intraoperative equianalgesic fentanyl and PFS (multivariate HR=1.05, 95% CI 0.632-1.73, P=0.861) and OS (multivariate HR=1.74, 95% CI 0.892-3.38, P = 0.105). Conclusion: Intraoperative opioids consumption was not correlated with outcomes of CRLM patients treated with simultaneous resection.
ABSOLUTE DIMENSIONS OF A FLAT HIERARCHICAL TRIPLE SYSTEM KIC 6543674 FROM THE KEPLER PHOTOMETRY

Many of the Kepler close binaries are suggested to constitute hierarchical triple systems through their eclipse timing variations (ETVs). Eclipses by the third body in those systems, if observed, provide precise constraints on its physical and orbital properties, which are otherwise difficult to obtain. In this Letter, we analyze such a “tertiary event” observed only once in the KIC 6543674 system. The system consists of a short-period ( 2.4 days ? > ) inner eclipsing binary and a third body on a wide ( 1100 days ? > ) and eccentric ( e ≃ 0.6 ? > ) orbit. Analysis of three tertiary eclipses around a single inferior conjunction of the third body yields the mutual inclination between the inner and outer binary planes to be 3 &fdg; 3 ± 0 &fdg; 6 ? > , indicating an extremely flat geometry. Furthermore, combining the timings and shapes of the tertiary eclipses with the phase curve and ETVs of the inner binary, we determine the mass and radius ratios of all three bodies in the system using the Kepler photometry alone. With the primary mass and temperature from the Kepler Input Catalog, the absolute masses, radii, and effective temperatures of the three stars are obtained as follows: M A = 1.2 ± 0.3 M ⊙ ? > , R A = 1.8 ± 0.1 R ⊙ ? > , M B = 1.1 − 0.2 + 0.3 M ⊙ ? > , R B = 1.4 ± 0.1 R ⊙ ? > , M C = 0.50 − 0.08 + 0.07 M ⊙ ? > , R C = 0.50 ± 0.04 R ⊙ ? > , T A ≃ T B ≃ 6100 K ? > , and T C < 5000 K ? > . Implication for the formation scenario of close binaries is briefly discussed.
A case study of the integration of Algorithm Visualizations in Hungarian programming education

In this study, I will introduce how Algorithm Visualizations (AV) can help programming education or, in this case, the acquisition of basic programming theorems. I used two di erent methods to test this: in the first round, I examined in a larger group how much the students' ability to solve specific tasks changes after being introduced to a visualization tool, and then, what was their motivation and experience during this process. In the second round, I looked for the components that could be important when choosing a tool with the help of an in-depth interview with a smaller number of individuals. In both cases, I describe the research, experience, and results of the study, and then summarize them at the end. Subject Classification: 97P10
Electrochemical Sensors and Their Applications: A Review

The world of sensors is diverse and is advancing at a rapid pace due to the fact of its high demand and constant technological improvements. Electrochemical sensors provide a low-cost and convenient solution for the detection of variable analytes and are widely utilized in agriculture, food, and oil industries as well as in environmental and biomedical applications. The popularity of electrochemical sensing stems from two main advantages: the variability of the reporting signals, such as the voltage, current, overall power output, or electrochemical impedance, and the low theoretical detection limits that originate from the differences in the Faradaic and nonFaradaic currents. This review article attempts to cover the latest advances and applications of electrochemical sensors in different industries. The role of nanomaterials in electrochemical sensor research and advancements is also examined. We believe the information presented here will encourage further efforts on the understanding and progress of electrochemical sensors.
Latch-Up Prevention With Autodetector Circuit to Stop Latch-Up Occurrence in CMOS-Integrated Circuits

Due to the parasitic silicon-controlled-rectifier structure, latch-up issues have been an inherent problem with bulk CMOS ICs. In this work, a novel design of an autodetector circuit to stop latch-up occurrence for latch-up prevention was proposed and successfully verified in a 0.18-μm 1.8/3.3-V CMOS technology. By adding a hole/electron detector between the input/output (I/O) pads and internal circuitry, it is used to detect the latch-up trigger current injected toward internal circuits. When an abnormal current is injected from the I/O pads to the internal circuits, this event can be detected by the proposed autodetector circuit.
“Balancing Field-General and Subfield-Specific Contributions When Addressing, Utilizing, or Assessing a Theory’s Explanatory Power”

ABSTRACT Explanatory power is a key criterion for assessing the strength of a theory. This essay provides an expanded detailing of explanatory power’s three components: Plausibility, range, and postdiction. In addition, a case is made for how plausibility advancements signal field-general contributions, range-based works gravitate toward subfield-specific offerings, and postdiction assessments can be field-general or subfield-specific. This discussion is grounded with a focus on four theories: Agenda Setting, Cultivation, Uses and Gratifications, and Social Cognitive Theory. Implications for future theory advancement are discussed and short- and long-term research initiatives are detailed.
On strong embeddings by Stein’s method

Strong embeddings, that is, couplings between a partial sum process of a sequence of random variables and a Brownian motion, have found numerous applications in probability and statistics. We extend Chatterjee's novel use of Stein's method for $\{-1,+1\}$ valued variables to a general class of discrete distributions, and provide $\log n$ rates for the coupling of partial sums of independent variables to a Brownian motion, and results for coupling sums of suitably standardized exchangeable variables to a Brownian bridge.
The influence of sustainability knowledge and attitude on sustainable intention and behaviour of Malaysian and Indonesian undergraduate students

The study aims to examine Malaysian and Indonesian undergraduate students’ sustainability knowledge and sustainable attitudes and the impact on their sustainability intention and sustainable behaviour. An online survey was conducted using 953 respondents. The SmartPLS (Partial Least Squares) analysis demonstrated that sustainability knowledge and sustainable attitude significantly impact the students’ sustainability intention. Nevertheless, the effect of sustainability knowledge was less than the sustainable attitude. The results confirmed that sustainability intention is important to influence sustainable behaviour among university students. Interestingly, Malaysian undergraduate students recorded higher effect levels of sustainability knowledge and attitude on sustainable intention and sustainability intention on sustainable behaviour compared to Indonesian students.
A four‐coil structure wireless power transfer system with constant current and constant voltage charging: Analysis, design, and experiment

Wireless power transfer (WPT) technology can transmit power through high‐frequency magnetic fields, which is safer and more flexible than conventional conductive charging method. The WPT systems for charging lithium batteries need to meet the charging function of first constant current (CC) and then constant voltage (CV). In addition, to avoid reactive power loss, the input impedance of the system is preferably purely resistive, that is, to meet the zero phase angle (ZPA) condition. In view of the above problems, this paper proposes a four‐coil structure WPT system based on dual‐frequency switching method to realize load‐independent CC and CV charging outputs at two fixed ZPA frequency points, respectively. It is worth noting that there is only one compensation capacitor on the receiving side, which ensures the compactness and portability of the receiving side of the WPT system. An experimental prototype with charging current of 2.2 A in CC mode and charging voltage of 28 V in CV mode is established to verify the correctness and practicality of the proposed four‐coil structure WPT system. The experimental results are basically in good agreement with the theoretical analysis.
Integrated dual‐band multiple‐input multiple‐output antenna module using higher mode control for 5G applications

This study presents a self‐decoupled and highly integrated multiple‐input multiple‐output (MIMO) antenna pair for the 3.5 GHz (3.4–3.6 GHz) and 5 GHz (4.8–5 GHz) frequency bands, where a loop‐type antenna and a dipole‐type antenna are assembled into the front and backside of a compact modular board. A tuning inductor and a tuning capacitor are employed in the loop‐type antenna and the dipole‐type antenna, respectively, for higher mode resonance control, such that the dominant mode and higher mode of each antenna element are excited to achieve dual‐band operation. Herein, the dominant modes of the loop‐type antenna and the dipole‐type antenna are orthogonal to each other, contributing to the self‐decoupling effect in the lower band. Otherwise, the modal orthogonality of the higher modes of the two antennas is responsible for the high‐isolated performance of the higher band. In this way, the proposed dual‐band MIMO antenna module obtains a high spatial utilization ratio, even though they are disposed of in the same volume. The MIMO antenna module can produce impedance bandwidths above 200 MHz at both frequency bands, and the isolation within the lower and higher bands is above 16.5 and 13.5 dB, respectively. Additionally, an 8 × 8 MIMO antenna array is further constructed and measured. In measurement, the total efficiencies are higher than 60%, and the envelope correlation coefficient values are all below 0.1. Therefore, it is demonstrated that the proposed technique can be promisingly applied in large‐scale MIMO antenna systems for current and future terminal devices, having advantages in multiband operation, high integration, and inherent isolation.
Targeted Next-Generation Sequencing-Based Multiple Gene Mutation Profiling of Patients with Rectal Adenocarcinoma Receiving or Not Receiving Neoadjuvant Chemoradiotherapy

This study investigated whether oncogenic and tumor-suppressive gene mutations are involved in the differential outcomes of patients with rectal carcinoma receiving neoadjuvant chemoradiotherapy (nCRT). Genomic DNA was obtained from formalin-fixed paraffin-embedded (FFPE) specimens of patients with rectal carcinoma who received a complete nCRT course. Gene mutation status was examined in specimens from patients before and after nCRT by using the AmpliSeq platform. Our data revealed that the nonsynonymous p53, APC, KRAS, CDKN2A, and EGFR mutations were observed in 93.1%, 65.5%, 48.6%, and 31% of the patients with rectal adenocarcinoma, respectively. BRAF, FBXW7, PTEN, and SMAD4 mutations were observed in 20.7% of patients with rectal carcinoma. The following 12 gene mutations were observed more frequently in the patients exhibiting a complete response than in those demonstrating a poor response before nCRT: ATM, BRAF, CDKN2A, EGFR, FLT3, GNA11, KDR, KIT, PIK3CA, PTEN, PTPN11, SMAD4, and TP53. In addition, APC, BRAF, FBXW7, KRAS, SMAD4, and TP53 mutations were retained after nCRT. Our results indicate a complex mutational profile in rectal carcinoma, suggesting the involvement of BRAF, SMAD4, and TP53 genetic variants in the outcomes of patients with nCRT.
Detection of Water Spread Area Changes in Eutrophic Lake Using Landsat Data

Adequate water resource management is essential for fulfilling ecosystem and human needs. Nainital Lake is a popular lake in Uttarakhand State in India, attracting lakhs of tourists annually. Locals also use the lake water for domestic purposes and irrigation. The increasing impact of climate change and over-exploration of water from lakes make their regular monitoring key to implementing effective conservation measures and preventing substantial degradation. In this study, dynamic change in the water spread area of Nainital Lake from 2001 to 2018 has been investigated using the multiband rationing indices, namely normalized difference water index (NDWI), modified normalized difference water index (MNDWI), and water ratio index (WRI). The model has been developed in QGIS 3.4 software. A physical GPS survey of the lake was conducted to check the accuracy of these indices. Furthermore, to determine the trend in water surface area for a studied period, a non-parametric Mann–Kendall test was used. San’s slope estimator test determined the magnitude of the trend and total percentage change. The result of the physical survey shows that NDWI was the best method, with an accuracy of 96.94%. Hence, the lake water spread area trend is determined based on calculated NDWI values. The lake water spread area significantly decreased from March to June and July to October at a 5% significance level. The maximum decrease in water spread area has been determined from March to June (7.7%), which was followed by the period July to October (4.67%) and then November to February (2.79%). The study results show that the lake’s water spread area decreased sharply for the analyzed period. The study might be helpful for the government, policymakers, and water experts to make plans for reclaiming and restoring Nainital Lake. This study is very helpful in states such as Uttarakhand, where physical mapping is not possible every time due to its tough topography and climate conditions.
Categorical segregation in social networks

This paper exploits a network formation game to analyze categorical thinking as a source of segregation. The link between categorical thinking and segregation was recently suggested by Fryer and Jackson (2008). The present model shows how segregation may emerge even when self-interested agents have no a priori motivation to do so; consequently, this paper supports the argument that segregation may not be malevolent in origin.
Transformation of survival data

It is good statistical practice to perform more than one analysis on a given data set. Normal theory methods usually provide one alternative. By employing transformations their domain of application can be greatly extended. Under normal theory, we have the advantage of simple interpretations of linear regression and interactions. Coupled with the relative ease of computation and availability of diagnostic techniques, for complete samples, normal theory has much to recommend it. Except for computational ease, the other advantages are retained in the survival analysis setting. By transforming survival data, and then applying parametric estimation methods, we obtain an estimated survival curve which may be compared to the Kaplan-Meier (1958) estimate. In a regression setting comparisons could be made with the analysis based on the Cox (1972) proportional hazards model, or the methods of Miller (1976), Buckley and James (1979) and Koul, Susarla and Van Ryzin (1981).
Some new regularity criteria for the 3D Navier-Stokes Equations

Several types of new regularity criteria for Leray-Hopf weak solutions $u$ to the 3D Navier-Stokes equations are obtained. Some of them are based on the third component $u_3$ of velocity under Prodi-Serrin index condition, another type is in terms of $\omega_3$ and $\partial_3u_3$ with Prodi-Serrin index condition. And a very recent work of the authors, based on only one of the nine entries of the gradient tensor, is renovated.
The Relationship between Social Support and Anxiety among Rural Older People in Elderly Caring Social Organizations: A Cross-Sectional Study

Background: Social support and anxiety have a major impact on later life quality in rural, older people in elderly caring social organizations (SOs). This study aimed to explore the relationship between social support and anxiety and their relevant influential factors among rural older people in elderly caring SOs in Anhui Province, China. Methods: This cross-sectional study was conducted through a multi-stage stratified cluster random sampling method. Independent t-tests, one-way ANOVA, Mann–Whitney U test, Kruskal–Wallis H test, and a generalized linear model were employed. Results: A significantly negative association between friends’ support and anxiety were found among rural older people in elderly caring SOs. Statistically significant relationships were found between social support and gender, marital status, education level, whether visited by relatives, and institutional satisfaction. Similarly, anxiety was associated with gender, institutional satisfaction, comorbid chronic diseases, and friends’ support. Conclusions: Social support from friends plays an important role in preventing and regulating anxiety among rural older people, especially those from elderly caring SOs. To reduce the occurrence and level of anxiety among rural elderly in elderly caring SOs, an effort should be given to strengthening social support, improving institutional satisfaction, and emphasizing comorbid chronic diseases.
Anticipatory Anxiety, Familiarization, and Performance: Finding the Sweet Spot to Optimize High-Quality Data Collection and Minimize Subject Burden

Accurate baseline data are essential for researchers to determine an intervention’s effects yet may be affected by anticipatory anxiety and assessment familiarity. Familiarization sessions help establish accurate baseline data. High-intensity functional training (HIFT) elicits performance outcomes based on constantly varied workouts. It is unclear how familiarization affects anticipatory anxiety and workout performance among HIFT novices. Familiarization was hypothesized to decrease anxiety and improve workout performance. Sixteen college-aged subjects (62.5% women, 20.2 ± 1.14 years) completed one introductory and four sessions of the same workout. All subjects were recreationally trained with no HIFT experience. State and trait anxiety were assessed at the first session. During the workout sessions, state anxiety (SQALS) was assessed upon arrival at the gym (SQALS 1), after learning the workout protocol (SQALS 2), and when the workout concluded (SQALS 3). A significant main effect of the number of previous sessions on workout performance was observed (p = 0.011). A repeated-measures ANOVA showed a main effect of time on SQALS 1 (p < 0.001), SQALS 2 (p < 0.001), and SQALS 3 (p < 0.001). Our results suggest implementing two familiarization sessions for our HIFT-based workout was sufficient to decrease anxiety and establish a baseline measurement. Future research should examine if this remains true for other types of HIFT-based workouts.
Feasibility of telemedicine research visits in people with Parkinson’s disease residing in medically underserved areas

Abstract Introduction: Gait, balance, and cognitive impairment make travel cumbersome for People with Parkinson’s disease (PwPD). About 75% of PwPD cared for at the University of Arkansas for Medical Sciences’ Movement Disorders Clinic reside in medically underserved areas (MUAs). Validated remote evaluations could help improve their access to care. Our goal was to explore the feasibility of telemedicine research visits for the evaluation of multi-modal function in PwPD in a rural state. Methods: In-home telemedicine research visits were performed in PwPD. Motor and non-motor disease features were evaluated and quantified by trained personnel, digital survey instruments for self-assessments, digital voice recordings, and scanned and digitized Archimedes spiral drawings. Participant’s MUA residence was determined after evaluations were completed. Results: Twenty of the fifty PwPD enrolled resided in MUAs. The groups were well matched for disease duration, modified motor UPDRS, and Montreal Cognitive assessment scores but MUA participants were younger. Ninety-two percent were satisfied with their visit, and 61% were more likely to participate in future telemedicine research. MUA participants traveled longer distances, with higher travel costs, lower income, and education level. While 50% of MUA participants reported self-reliance for in-person visits, 85% reported self-reliance for the telemedicine visit. We rated audio-video quality highly in approximately 60% of visits in both groups. There was good correlation with prior in-person research assessments in a subset of participants. Conclusions: In-home research visits for PwPD in MUAs are feasible and could help improve access to care and research participation in these traditionally underrepresented populations.
An Independence Test for Continuous and Categorical Ordinal Data Based on a Sign Correlation Related to Kendall's Tau

The standard two-variable chi-square test is typically consistent for all alternatives to independence, but effectively treats the data as nominal which may lead to loss of power for ordinal data. Alternatively, a test based on Kendall's tau does take ordinality into account, but only has power against a narrow set of alternatives. This paper introduces a new test aimed at filling this gap, i.e., it is designed for ordinal data and to have omnibus asymptotic power. Our test is a permutation test based on a modification of Kendall's tau, denoted τ*. Based on partial proofs and numerical evidence, we conjecture τ* to be nonnegative, and zero if and only if independence holds. An interpretation of τ* in terms of concordance and discordance for sets of four observations is given. The new coefficient is a sign version of a correlation coefficient introduced by Bergsma (2006).