Miracle-dz/UniFAR-FTUs huggingface dataset:
Human papillomavirus detection in dysplastic and malignant oral verrucous lesions

The role of human papillomaviruses (HPV) in dysplastic and malignant oral verrucous lesions is controversial since there is a wide range in the incidence of virus detection. This study used a multi-tiered method of HPV detection using DNA in-situ hybridisation (ISH) for low- and high-risk subtypes, consensus PCR, and HPV genotype analysis in archival tissue from 20 cases of dysplastic and malignant oral verrucous lesions. The biological significance of HPV DNA detection was assessed by p16 immunohistochemistry (IHC). While 1/7 carcinomas and 5/13 dysplasias contained HPV DNA by consensus PCR and genotype analysis, all specimens were negative for low- and high-risk HPV ISH and negative for p16 IHC. Results show that although high-risk HPV DNA is detectable in a subset of these lesions, the lack of p16 overexpression suggests that the oncogenic process is not driven by HPV oncoproteins.
Integrated approach to the design of wind farm infrastructure

A part of the wind farm layout optimization is the design of the wind farm infrastructure, that includes roads and the electrical collector system. The cost of the wind farm infrastructure is a minor part of the total cost. However, its variability with different layouts influences the optimal layout of the wind farm. The aim of this paper is to develop a realistic model for the wind farm infrastructure and propose a fast algorithm for solving the problem. First, the road layout is found using the Dijkstra's shortest path algorithm, considering the existing roads. After that, the collector system is optimized using metaheuristic Cuckoo Search algorithm, taking into account information about previously found road layout and the lifetime costs of the cables, power losses and outages. A Genetic algorithm is used as a benchmark for comparing the performance of the Cuckoo Search algorithm.
Prognostic and predictive significance of proliferation in 867 colorectal cancers

Aim Recently, the Oncotype DX recurrence score, which measures a gene expression signature including markers of tumour proliferation, was validated as a prognostic signature in colorectal cancer. This study aimed to evaluate whether the Ki67 proliferation index can provide similar prognostic and predictive information. Methods Tissue microarrays were constructed from triplicate cores of colorectal cancer. Immunohistochemistry for Ki67 was performed with the SP6 antibody and the percentage of positive tumour cells scored. Prognostic significance was evaluated in 867 cancers (601 events) using Cox proportional hazards models. Results The Ki67 labelling index, divided at the median, was not a statistically or clinically significant prognostic factor in univariate analyses of 5-year overall survival (HR 0.98, 95% CI 0.84 to 1.15, p=0.84). Multivariate analyses were similarly non-significant. However, in Dukes’ stage C patients, the high Ki67 subgroup derived a greater 5-year overall survival benefit from chemotherapy (HR 0.32, 95% CI 0.21 to 0.51, p<0.0001) than the low subgroup (HR 0.57, 95% CI 0.37 to 0.89, p=0.011). Conclusions The Ki67 proliferation index is not a useful prognostic factor in colorectal cancer, but deserves further evaluation as a predictive factor for the incremental benefit derived from adjuvant chemotherapy.
Drug Addiction in Bangladesh and its Effect

Drug addiction and drug abuse, chronic or habitual use of any chemical substance to alter states of body or mind for other than medically warranted purposes. Addiction is more often now defined by the continuing, compulsive nature of the drug use despite physical and/or psychological harm to the user and society and includes both licit and illicit drugs, and the term "substance abuse" is now frequently used because of the broad range of substances (including alcohol and inhalants) that can fit the addictive profile. Psychological dependence is the subjective feeling that the user needs the drug to maintain a feeling of well-being; physical dependence is characterized by tolerance (the need for increasingly larger doses in order to achieve the initial effect) and withdrawal symptoms when the user is abstinent. There are a lot of effects of drug addiction to the economy, society, and family. Drug addiction affects individual's physical and mental health. Drug addicts are burden for a family and society. It is a great challenge for all nations of the world to prevent drug addiction. This article reviews the effects of drug addiction in details. DOI: http://dx.doi. org/10.3329/medtoday.v25i2. 17927 Medicine Today 2013 Vol.25(2): 84-89
Treatment and treatment outcomes in children’s homes

A follow-up study of 141 young people in 48 children’s homes examined changes in their moods, relationships with their family and adjustment. The average scores of the group on these variables changed little between first interview and follow-up 6–9 months later. However, some individuals improved and others deteriorated. Improvements in family relationships were more likely in homes where the head of home could describe strategies for fostering family ties. Improvements in adjustment were also more likely in homes where the head of home could articulate ways of enabling change in key areas of the residents’ lives. Residents who spoke of attempts to bully them were more distressed at the time of the first interview and less adjusted at follow-up. The study underlines the damaging effects of bullying and the key role of the head of home.
Overcoming the linguistic divide: a barrier to consumer health information

Seeking health information online has become very popular. Despite this popularity, health consumers face many barriers to successfully retrieving good quality health information. This paper reviews the literature on the lin- guistic divide between health consumers and consumer health information. Consumer health vocabularies (CHV) and natural language processing (NLP) show potential for bridging the divide, thereby improving recall and precision from information retrieval systems. Developers of digital libraries can incorporate CHV and (or) NLP as help tools to facili- tate health consumers' search success. Deeper issues, such as health consumers' mental representation of medical do- main, must also be addressed in future research for optimal benefit from such help tools.
An integrative view of storage of low-and high-level visual dimensions in visual short-term memory

Efficient performance in an environment filled with complex objects is often achieved through the temporal maintenance of conjunctions of features from multiple dimensions. The most striking finding in the study of binding in visual short-term memory (VSTM) is equal memory performance for single features and for integrated multi-feature objects, a finding that has been central to several theories of VSTM. Nevertheless, research on binding in VSTM focused almost exclusively on low-level features, and little is known about how items from lowand high-level visual dimensions (e.g., colored manmade objects) are maintained simultaneously in VSTM. The present study tested memory for combinations of low-level features and high-level representations. In agreement with previous findings, Experiments 1 and 2 showed decrements in memory performance when non-integrated lowand high-level stimuli were maintained simultaneously compared to maintaining each dimension in isolation. However, contrary to previous findings the results of Experiments 3 and 4 showed decrements in memory performance even when integrated objects of lowand highlevel stimuli were maintained in memory, compared to maintaining single-dimension objects. Overall, the results demonstrate that lowand high-level visual dimensions compete for the same limited memory capacity, and offer a more comprehensive view of VSTM.
General practitioner and specialist care: the perceptions of people with rheumatoid arthritis

Objective: The care of patients with chronic diseases such as rheumatoid arthritis is increasingly shared between primary health care and hospital specialist teams. Studies that have informed guidelines for the shared care of patients with rheumatoid arthritis have not included patients' perceptions and preferences. The objective of this study was to explore the experiences and views of patients with rheumatoid arthritis concerning the clinical care they had received from general practitioners (GPs) and specialist hospital doctors. Design: Semi-structured interviews analysed using grounded theory techniques. Setting and Participants: A purposeful sample of twelve people receiving clinical care from specialist rheumatologists and GPs. All participants had received a diagnosis of rheumatoid arthritis at least two years previously. Results: Most participants valued regular review by rheumatologists highly, and looked to them for help with all aspects of their arthritis care. They felt that specialists had greater knowledge concerning disease management than GPs, but both groups of doctors were similarly empathic. The GPs' role was perceived to be important mainly in early diagnosis and first referral to the hospital specialist but less so in the provision of continuing care or help with psychosocial issues. Participants valued the accessibility of GP services. Advice from any source about aids and welfare benefits was often haphazard. Conclusions: People with rheumatoid arthritis prefer to have regular contact with a rheumatologist rather than obtaining care for their arthritis mainly from their GP. This has implications for the move from secondary to primary care.
Malignant melanoma showing a rapid response to nivolumab

Malignant melanoma is a highly aggressive skin tumour, with a recent rise in incidence. Nivolumab is a recently developed anti‐programmed cell death‐1 immune checkpoint inhibitor and its usage has resulted in a significant improvement in the overall survival of patients with metastatic melanomas. We report a case of advanced melanoma that showed a significant and rapid response to nivolumab treatment. The patient displayed multiple melanoma‐associated vitiligo prior to treatment; this symptom was theorised to indicate potentially immunoreactive melanoma and the need for nivolumab. In addition, interferon‐β was injected prior to nivolumab treatment. The significant rapid response to nivolumab suggested the induction of a marked immune response against melanoma by interferon‐β. Therefore, interferon‐β could be a useful and effective adjuvant for nivolumab therapy.
Prevalence of Staphylococcus aureus subsp. anaerobius in sub-clinical abscess cases of sheep.

Aim: To investigate the prevalence of Staphylococcus aureus subsp. anaerobius (Saan) in sub-clinical lymph node abscesses (SLNA) in sheep. Place and Duration of Study: Department of Microbiology (Faculty of Veterinary Medicine) and Unit Microbiology and Molecular Biology (Institute for Studies and Promotion of Animal Exports), between May 2003 and Dec. 2005. Methodology: Enlarged superficial lymph nodes (n=137) were taken from sheep carcasses at meat inspection and were subjected for bacteriological examination. Results: Pure cultures of Saan were obtained from 44% of the pus samples, Corynebacterium spp. from 33% and S. aureus subsp. anaerobius from 7%. The rest of the pus samples yielded mixed cultures of Saan with either Macrococcus caseolyticus (10%) or Corynebacterium spp. (6%). Conclusion: Although these results show S. aureus subsp. anaerobius as the prime cause of SLNA, they also show the importance of inclusion of Corynebacterium pseudotuberculosis in vaccine developments or vaccination protocols against abscess Shortcommunication
Audio Feature and Classifier Analysis for Efficient Recognition of Environmental Sounds

Environmental sounds (ES) have different characteristics, such as unstructured nature and typically noise-like and flat spectrums, which make recognition task difficult compared to speech or music sounds. Here, we perform an exhaustive feature and classifier analysis for the recognition of considerably similar ES categories and propose a best representative feature to yield higher recognition accuracy. In the experiments, thirteen (13) ES categories, namely emergency alarm, car horn, gun, explosion, automobile, helicopter, water, wind, rain, applause, crowd, and laughter are detected and tested based on eleven (11) audio features (MPEG-7 family, ZCR, MFCC, and combinations) by using the HMM and SVM classifiers. Extensive experiments have been conducted to demonstrate the effectiveness of these joint features for ES classification. Our experiments show that, the joint feature set ASFCS-H (Audio Spectrum Flatness, Centroid, Spread, and Audio Harmonicity) is the best representative feature set with an average F-measure value of 80.6%.
Efficient Buffer Output Control for Multimedia Stream Playback

Recently, it has become a major network application to use mobile devices to watch multimedia streams through the network or Internet. Buffer overflow/underflow caused by an unstable network(e.g. a weak wireless connection) is very likely to result in flickering or stuttering playback of a media stream. A general but complicated solution is to implement complex streaming protocol to control the output of stream data. However, it comes with higher development and maintenance costs and also reduces the flexibility of integrating compatible player software. In this paper, we propose an efficient playback buffer output control mechanism. The media timestamp, sleep instruction and system time are employed to regulate the output of stream data. Evaluation results prove that the proposed mechanism achieves high output accuracy and minimize output jitters of stream data.
A SPECIAL FORM OF FUNCTIONAL PSYCHONEUROSES APPEARING IN AIRPLANE PILOTS

The clinical material on which this study was based consisted of 163 unselected airplane pilots. Their ages ranged from 22 to 50 years inclusive, their flying experience from one to eighteen years and their total flying time from 400 to 5,680 hours. The data presented were derived from three principal sources; namely, close personal observation of each individual for from six months to three years, annual and semiannual physical examinations for flying, and professional attendance on all accidents and illnesses occurring in this group. HISTORICAL Among pilots of all countries involved in the World War there was an enormous percentage invalided because of functional nervous disorders. Probably the best description of these cases was presented by H. Graeme Anderson1of England in 1919. Anderson recognized and described the various neuroses that occurred and they were admittedly no different from functional neuroses in other branches of the service or those
Confidence and Expectations About Caring for Older People With Dementia: A Cross-Sectional Survey of Student Nurses

Older people who are living with dementia often need healthcare, including hospital admissions, due to additional health conditions. Caring for older people who are living with dementia is, therefore, a core nursing role. This study investigated student nurses’ expectations of, and confidence about, caring for older people with dementia and the effect of students’ age, precourse experience, and their academic year. The design was a cross-sectional survey using questionnaires to collect data. The participants (n = 328), based at one university in England, had all had at least one practice learning placement. Most student nurses (n = 202; 62%) had precourse contact with older people with dementia and had cared for them during the course (n = 291; 89%). The student's academic year significantly affected confidence about caring for older people with dementia (p = .006), but still only 52% (n = 26) of third-year students felt “generally confident. ” Precourse contact with older people with dementia had a significant impact on expectations (p = .001) and confidence in caring for people with dementia (p = .002). Students who were >25 years were significantly more likely to have had precourse contact with older people with dementia (p = < .001). Nurse educators should ensure that students entering nurse education appreciate that caring for older people who are living with dementia will be a core part of their role. They must proactively prepare nursing students to care for people with dementia, recognizing that some students have no previous contact, which may affect their confidence and experiences.
Digital Diorama system for museum exhibition

In this paper, we proposed the Digital Diorama system to convey background information vividly. The system superimposes computer generated diorama scene reconstructed from related image/video materials on real exhibits. In order to switch and superimpose real exhibits and past photos seamlessly, we implement a matching system for estimating the camera position where photos are taken. By applying this subsystem to 26 past photos about the steam locomotive exhibit, we succeeded in estimating their camera position. Thus, we implement and install a prototype system at estimated position to superimposing virtual scene and real exhibit in the Railway Museum.
Decision modelling for health economic evaluation

Edited by Andrew Briggs, Mark Sculpher and Karl Claxton. Oxford, Oxford University Press, 2006, £24.95, pp 237. ISBN 10: 0-19-852662-8, ISBN 13: 978-0-19-852662-9, 37 figures and 33 tables. Economists are great model builders. Studying human behaviour has taught them to rely on assumptions (prior beliefs) and to use sophisticated mathematics and statistical techniques to reach outcomes (posteriors). In clinical trials the researcher is often restricted by instrumental precision (priors) and applies statistical techniques to reach scientific breakthroughs (posteriors). However, in a world of finite resources, it is inevitable that there has to be a limit on the number of trials that can be carried …
[Poster] View management for webized mobile AR contents

Information presentation techniques are important in augmented reality applications as they are in the traditional desktop user interface (WIMP) and web user interface [6]. This paper introduces view management for a web-based augmented reality mobile platform. We use a webized mobile AR browser called Insight that provides separation of the application logic, including the tracking engine and AR content, so that the view management logic and contents are easy to reuse. In addition, the view management is able to accommodate in-situ context of an AR application.
A Systematic Review of Usability Studies in Augmented Reality between 2005 and 2014

Augmented Reality (AR) interfaces have been studied extensively over the last few decades, with a growing number of user-based experiments. In this paper, we systematically review most AR papers published between 2005 and 2014 that include user studies. A total of 291 papers have been reviewed and classified based on their application areas. The primary contribution of the review is to present the broad landscape of user-based AR research, and to provide a high-level view of how that landscape has changed. We also identify areas where there have been few user studies, and opportunities for future research. This poster describes the methodology of the review and the classifications of AR research that have emerged.
Cetuximab: a critical appraisal of a novel development in the treatment of squamous cell carcinoma of the head and neck

Abstract Recently published evidence has shown an improvement in locoregional control and a survival advantage in the treatment of squamous cell carcinomas of the head and neck (SCCHN) using cetuximab, a monoclonal antibody that inhibits the tumour-promoting mechanism of the epidermal growth factor receptor (EGFR). In a large randomised trial, cetuximab was delivered concurrently with radiotherapy and compared to radiotherapy alone in locally advanced SCCHN. The trial showed that the addition of cetuximab offers improved locoregional control and survival without enhancing acute toxicity compared to radiotherapy alone. These exciting results have the potential to change standard head and neck cancer practice, impacting on head and neck cancer services provided by oncology departments and multidisciplinary working. This article aims to define the mechanism of action of cetuximab, critically appraise the evidence for the use of cetuximab within Oncology departments for SCCHN, and critically evaluate how cetuximab may impact on current practice. Future possibilities and trials to assess the use of cetuximab within clinical practice will also be discussed.
Coping responses as predictors of psychosocial functioning amongst individuals suffering from chronic pain

ABSTRACT Background: Research on coping with chronic pain has focused on exploring the impact of different coping responses on various aspects of living with chronic pain. The aim of this study is to determine whether certain coping responses can be identified as predictors of the level of pain intensity reported by the chronic pain patient, as well as predictors of these individuals' psychosocial functioning. Methods: One hundred and seventy-two individuals suffering from chronic pain completed both the West Haven-Yale Multidimensional Pain Inventory and the Coping Responses Inventory—Adult Form. The prevalence of the use of Avoidance and Approach Coping, and the relationship between these responses and psychosocial functioning (Pain Severity, Interference, Support, Life Control, and Affective Distress) were explored. Hierarchical regression analyses were performed in order to determine the amount of variance explained by the specific predictor variables. Results: The findings of this research suggest that coping responses do impact upon the psychosocial functioning of individuals with chronic pain, and more specifically, on the level of interference, severity of pain, perceived amount of control over life and the amount of emotional distress experienced by these patients. Conclusion: The outcomes of this study appear to contradict the general consensus in literature that regards Approach Coping responses as being associated with decreased pain severity and improved psychosocial functioning. The manner in which specific components of each type of coping response relates to specific aspects of psychosocial functioning was investigated; an aspect that was found to be lacking in most research regarding coping and chronic pain.