Miracle-dz/UniFAR-FTUs huggingface dataset:
Green Industrial Internet of Things Architecture: An Energy-Efficient Perspective

The Internet of Things (IoT) can support collaboration and communication between objects automatically. However, with the increasing number of involved devices, IoT systems may consume substantial amounts of energy. Thus, the relevant energy efficiency issues have recently been attracting much attention from both academia and industry. In this article we adopt an energy-efficient architecture for Industrial IoT (IIoT), which consists of a sense entities domain, RESTful service hosted networks, a cloud server, and user applications. Under this architecture, we focus on the sense entities domain where huge amounts of energy are consumed by a tremendous number of nodes. The proposed framework includes three layers: the sense layer, the gateway layer, and the control layer. This hierarchical framework balances the traffic load and enables a longer lifetime of the whole system. Based on this deployment, a sleep scheduling and wake-up protocol is designed, supporting the prediction of sleep intervals. The shifts of states support the use of the entire system resources in an energy-efficient way. Simulation results demonstrate the significant advantages of our proposed architecture in resource utilization and energy consumption.
Self-folding cell origami: Batch process of self-folding 3D cell-laden microstructures actuated by cell traction force

We use cell traction force (CTF) to self-fold flat microplates into diverse three-dimensional (3D) cell-laden microstructures (Figure 1). Cells were selectively cultured onto the flat microfabricated plates. Immediately after detaching the plates from the glass substrate, the plates were lifted and folded up into the 3D microstructures due to the CTF caused by stretched cells that adhered between two plates. We achieved precise folding angles between the folding microplate and glass substrate by producing a flexible joint between the plates. Using the microplates with the flexible joint, we also achieved batch process of self-folding 3D cell-laden microstructures. In addition, we succeed to produce micro-flapping structures using cardiomyocytes as an actuator.
Evolution process of a wideband dual polarized MIMO antenna system for wireless Access Point applications

In this Paper evolution process of a wideband multiple-input multiple-output (MIMO) antenna system applicable for indoor wireless Access Point (WAP) is presented. The MIMO antenna system consists of two common element microstrip-fed monopole antennas with dual polarization. Due to the physically common integration of the MIMO antenna system, maintaining a high level of isolation between the antennas is a difficult design challenge. Here, a new parasitic element is introduced in order to improve the performance of the isolation between the ports. The proposed MIMO antenna system is simulated and optimized using CST Microwave Studio. The designed antenna system was fabricated and measurement was conducted to compare the simulation and measurement results. The simulated and measured -15 dB coupling coefficient is 23% (2.3 to 2.9 GHz) to cover WiFi 2.4 GHz and long term evolution (LTE) 2.6GHz applications.
Protection from diclofenac-induced small intestinal injury by the JNK 10 inhibitor SP 600125 in a mouse model of NSAID-associated enteropathy 11 12 13

39 40 Small intestinal ulceration, bleeding, and inflammation are major adverse effects 41 associated with the use of diclofenac (DCF) or other nonsteroidal anti-inflammatory 42 drugs (NSAIDs). The underlying mechanisms of DCF enteropathy are poorly understood, 43 but there is increasing evidence that topical effects are involved. The aim of this study 44 was to explore the role of c-Jun-N-terminal kinase (JNK) in DCF-induced enterocyte 45 death because JNK not only regulates mitochondria-mediated apoptosis but also is a key 46 node where many of the proximal stress signals converge. Male C57BL/6 mice were 47 injected intraperitoneally with DCF or vehicle (solutol HS-15), and the extent of small 48 intestinal ulceration was determined. A single dose of DCF (60 mg/kg) produced 49 numerous ulcers in the third and fourth quartiles of the jejunum/ileum, with maximal 50 effects after 18 h and extensive recovery after 48 h. To study the molecular pathways 51 leading to enterocyte injury, we isolated villi-enriched mucosal fractions from DCF52 treated mice. Immunoblot studies with a phosphospecific JNK antibody revealed that 53 JNK1/2 (p46) was activated at 6 h, leading to phosphorylation of the downstream target 54 c-Jun. The levels of the JNK-regulated proapoptotic transcription factor CHOP were also 55 increased after DCF. The selective JNK inhibitor, SP600125 (30 mg/kg, ip), given both 1 56 h before and 1 h after DCF, blocked JNK kinase activity and afforded significant 57 protection against DCF enteropathy. In conclusion, these data demonstrate that the JNK 58 pathway is critically involved in the pathogenesis of DCF-induced enteropathy and 59 suggest a potential application of JNK inhibitors in the prevention of NSAID-induced 60 enteropathy. 61 62 63 64
Viscous Lengths in Hydrodynamic Turbulence are Anomalous Scaling Functions.

It is shown that the idea that scaling behavior in turbulence is limited by one outer length $L$ and one inner length $\eta$ is untenable. Every n'th order correlation function of velocity differences $\bbox{\cal F}_n(\B.R_1,\B.R_2,\dots)$ exhibits its own cross-over length $\eta_{n}$ to dissipative behavior as a function of, say, $R_1$. This length depends on $n$ {and on the remaining separations} $R_2,R_3,\dots$. One result of this Letter is that when all these separations are of the same order $R$ this length scales like $\eta_n(R)\sim \eta (R/L)^{x_n}$ with $x_n=(\zeta_n-\zeta_{n+1}+\zeta_3-\zeta_2)/(2-\zeta_2)$, with $\zeta_n$ being the scaling exponent of the $n$'th order structure function. We derive a class of scaling relations including the ``bridge relation" for the scaling exponent of dissipation fluctuations $\mu=2-\zeta_6$.
articleMacular thickness measurements in healthy Norwegian volunteers : an optical coherence tomography study

Background: Ethnic, intersubject, interoperator and intermachine differences in measured macular thickness seem to exist. Our purpose was to collect normative macular thickness data in Norwegians and to evaluate the association between macular thickness and age, gender, parity, and contraception status. Methods: Retinal thickness was measured by Stratus Optical Coherence Tomography in healthy subjects. Mean macular thickness (MMT) was analyzed by repeated measures ANOVA with three dependent regional MMT-variables for interaction with age, gender, parity and oral contraception use. Exploratory correlation with age by the Pearson correlation test, both before and after stratification by gender was performed. Differences in MMT between older and younger subjects, between oral contraception users and non-users, as well as parous and nulliparous women were studied by post-hoc Student's t-tests. Results: Central MMT in Norwegians was similar to values earlier reported in whites. MMT in central areas of 1 and 2.25 mm in diameter were higher in males than in females. In younger subjects (≤43 years) differences in MMT between genders were larger than in the mixed age group, whereas in older subjects (>43 years) the small differences did not reach the set significance level. No differences were found in minimal foveolar thickness (MMFT) between the genders
MLN64 Mediates Mobilization of Lysosomal Cholesterol to Steroidogenic Mitochondria* 210

This study demonstrates that the steroidogenic acute regulatory protein-related lipid transfer (START) domain-containing protein, MLN64, participates in intracellular cholesterol trafficking. Analysis of the intracellular itinerary of MLN64 and MLN64 mutants tagged with green fluorescent protein showed that the N-terminal transmembrane domains mediate endocytosis of MLN64 from the plasma membrane to late endocytic compartments. MLN64 constitutively traffics via dynamic NPC1-containing late endosomal tubules in normal cells; this dynamic movement was inhibited in cholesterol-loaded cells, and MLN64 is trapped at the periphery of cholesterol-laden lysosomes. The MLN64 START domain stimulated free cholesterol transfer from donor to acceptor mitochondrial membranes and enhanced steroidogenesis by placental mitochondria. Expression of a truncated form of MLN64 (ΔSTART-MLN64), which contains N-terminal transmembrane domains but lacks the START domain, caused free cholesterol accumulation in lysosomes and inhibited late endocytic dynamics. The ΔSTART-MLN64 dominant negative protein was located at the surface of the cholesterol-laden lysosomes. This dominant negative mutant suppressed steroidogenesis in COS cells expressing the mitochondrial cholesterol side chain cleavage system. We conclude that MLN64 participates in mobilization and utilization of lysosomal cholesterol by virtue of the START domain's role in cholesterol transport.
Application of different machine learning techniques in identifying features of protein sequence data

This study is carried out on application of different machine learning techniques for prediction of features using bioinformatics data such as that of cancer. The prediction process is undertaken based on feature extraction and then on feature selection process. After selecting the relevant features, machine learning techniques like Support vector machine (SVM), Extreme learning machine (ELM) are applied for classification of the right kind of features. The results obtained with these classifiers are then tested using various test datasets like egfr, TP53, cosmic2plus etc, in order to identify cancer-associated mutations and passenger mutations i.e. neutral polymorphism.
Imaging Procedures in Neuroendocrine Tumours

Purpose: To give recommendations for diagnostic imaging workflow in suspected neuroendocrine tumours. Materials and Methods: Recommendations for imaging workflow were elaborated by consensus of researchers in neuroendocrine tumours. Results: Workflow charts are presented for: (1) nonfunctional and functional endocrine tumours of the pancreas (except insulinoma); (2) insulinoma; (3) ECL cell tumour; (4) assessment of unknown primaries in functional and nonfunctional neuroendocrine tumours of the gut; (5) assessment of metastases in functional and nonfunctional neuroendocrine tumours of the gut. Conclusions: The workflow charts facilitate diagnosis of neuroendocrine tumours as well as the design of controlled studies.
Neural network based handwritten character recognition system without feature extraction

Handwriting recognition has been one of the active and challenging research areas in the field of image processing and pattern recognition. It has numerous applications which include, reading aid for blind, bank cheques and conversion of any hand written document into structural text form. In this paper an attempt is made to recognize handwritten characters for English alphabets without feature extraction using multilayer Feed Forward neural network. Each character data set contains 26 alphabets. Fifty different character data sets are used for training the neural network. The trained network is used for classification and recognition. In the proposed system, each character is resized into 30×20 pixels, which is directly subjected to training. That is, each resized character has 600 pixels and these pixels are taken as features for training the neural network. The results show that the proposed system yields good recognition rates which are comparable to that of feature extraction based schemes for handwritten character recognition.
Analysis of thresholding techniques for asymmetrical annular flow image

This paper present the result of a study the behaviour of asymmetrical annular two-phase gas-liquid flow at different gas and liquid flow rate by using several thresholding techniques. The behaviour of annular flow is analysed base on liquid film thickness which is calculated after thresholding process. Thresholding techniques are applied on the images which are captured by Electrical Capacitance Tomography (ECT) in vertical upward flow. The results at the end of this report show which thresholding techniques that able to yield good thresholding images and show the liquid film thickness of annular two-phase flow at different gas and liquid flow rate.
Enzymatic assay for gentamicin and related aminoglycoside antibiotics.

An improved enzymatic assay has been developed for the rapid quantitative measurement of gentamicin or tobramycin in serum and other biological fluids. The assay uses a crude enzyme from Escherichia coli W677/HJR66 that adenylates gentamicin or tobramycin in the presence of adenosine-5'-triphosphate (ATP). Enzymatic adenylation of gentamicin is optimal at 8 mM Mg2+, and the Michaelis constant (K,,) of the enzyme for ATP is 0.043 mM. The modifications introduced here increase the sensitivity and decrease the background radioactivity of the previously described assay. The amount of 14C-ATP required per assay is also reduced, thereby decreasing the cost of the assay. The accuracy of the present method has been demonstrated both in control experiments and with 96 specimens of serum from 59 patients treated with gentamicin. Ten other commonly used antibiotics structurally unrelated to aminoglycosides were tested and do not interfere with the assay. The present method is not suitable for kanamycin assays because the crude enzyme used contains activities that catalyze two different ATP-dependent reactions leading to phosphorylation or adenylation of kanamycin.
Hormonal and environmental control of song control region growth and new neuron addition in adult male house finches, Carpodacus mexicanus

In songbirds, testosterone (T) mediates seasonal changes in the sizes and neuroanatomical characteristics of brain regions that control singing (song control regions; SCRs). One model explaining the mechanisms of the growth of one SCR, the HVC, postulates that in the spring increasing photoperiod and circulating T concentrations enhance new neuron survival, thus increasing total neuron number. However, most research investigating the effects of T on new neuron survival has been done in autumn. The present study investigated the effects of photoperiod and T treatment on SCR growth and new neuron survival in the HVC in photosensitive adult male House Finches, Carpodacus mexicanus, under simulated spring‐like conditions. Birds were castrated, given T‐filled or empty Silastic capsules and maintained on short days (SD; 8L:16D) or long days (LD; 16L:8D). To mark new cells, birds received bromodeoxyuridine injections 11 days after experimental manipulations began and were sacrificed 28 days later. Testosterone treatment increased the sizes of two SCRs, the HVC and Robust nucleus of the arcopallium (RA). Exposure to LD did not affect HVC volume, but did increase RA volume. Testosterone treatment increased the total number of HVC neurons, but did not affect the number of new HVC neurons. Thus, T initiates SCR growth and increases neuron survival, but effects of T on new neuron incorporation may be limited in photosensitive birds under spring‐like conditions. These results provide new insight into the effects of photoperiod and T treatment on vernal SCR growth and new neuron incorporation and support current models explaining this growth. © 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2007.
Monte Carlo dosimetric parameter study of a new (32)P brachytherapy source.

OBJECTIVE Recently, a new catheter-based (32)P brachytherapy source has been developed (College of Chemistry, Sichuan University) for use in high-dose-rate afterloader. This study presents the results of the dosimetric data of the Geant4 Monte Carlo (MC) simulation toolkit for this new (32)P brachytherapy source. METHODS The new (32)P source had dimensions of 0.50-cm length and 0.08-cm diameter and was encapsulated in teflon. In this study, we attempted to obtain dosimetric data for this new source, as required by the formalism proposed by the American Association of Physicists in Medicine reports TG60 and TG149. The source was located in a 30-cm radius theoretical sphere water phantom, and the absorbed dose of the source was calculated using MC code. RESULTS The dosimetric data included the reference absorbed dose rate, the radial dose function in the range of 0.10-0.50 cm at a longitudinal axis, the polynomial function for the radial dose function and the anisotropy function with a θ value of 0-90° in 5° intervals and an r of 0.10-0.35 cm in 0.01-cm intervals. The radial and axial dose profiles and away-along quality assurance table are also calculated for the unsheathed (32)P source. The dose rate D(r0,θ0) at the reference point for the unsheathed (32)P source is determined to be equal to 1.2660 ± 0.0006 cGy s(-1) mCi. The radial dose function of the new (32)P source shows good agreement with the other (32)P source presented in this work with an average difference of 1.78%. CONCLUSION Dosimetric data are provided for the new (32)P source. These data could be used in treatment-planning systems in clinical practice. ADVANCES IN KNOWLEDGE Provided a new beta-emitting brachytherapy source that is intended for treatment of liver cancer. A dosimetric study of the unsheathed (32)P source for which no published dosimetric data existed was performed.
Feeling Fine: Anxiety and Depressive Symptoms in Youth with Established IBD

Background:Previous research is discrepant with respect to the prevalence of internalizing symptoms (i.e., depressive and anxiety symptoms) in pediatric inflammatory bowel disease (IBD) samples. Moreover, few studies have examined the combined influence of demographic and disease-related risk factors for internalizing symptoms. This study described rates of depressive, anxiety, and overall internalizing symptomatology in a multisite sample of youth with established IBD diagnoses. Additionally, the study examined risk factors for elevated depressive, anxiety, and internalizing symptoms, including those in demographic (i.e., family income and sex) and disease (i.e., disease activity and functional disability) domains. Methods:One hundred sixty-one youth (aged 11–18 yr) with established IBD diagnoses, primarily inactive disease, prescribed oral medications, and who were not taking corticosteroids were recruited from outpatient Gastroenterology Clinics at 3 children's hospitals. This article reflects a secondary analysis of data collected from 2 larger studies examining oral medication adherence and psychosocial functioning in pediatric IBD. After providing written consent/assent, participants completed questionnaires assessing demographics, functional disability, and internalizing symptoms. Medical records were reviewed for disease information and clinical disease activity ratings. Results:Only 13% of the sample reported clinically elevated anxiety or depressive symptoms. Perceived functional disability, but not clinical disease activity, was associated with higher depressive and anxiety symptoms, and higher overall internalizing symptomatology. Conclusions:Current results highlight the need to look beyond disease severity and examine the perception of functional disability of patients with IBD when seeking to identify youth at risk for internalizing symptoms such as depression and anxiety.
Cognitive Distances in Prior Art Search by the Triadic Patent Offices: Empirical Evidence from International Search Reports

Despite large numbers of empirical studies being conducted on examiner patent citations, few have scrutinized the cognitive limitations of officials at patent offices in searching for prior art to add patent citations during patent prosecution. This research takes advantage of the longitudinal gap between international search reports (ISRs) required by the Patent Cooperation Treaty (PCT) and subsequent examination procedures in national phases. It inspects whether several kinds of distances actually affect the probability that a piece of prior art is caught at the time of ISRs, which is much earlier than national phase examinations. Based on triadic PCT applications for all of the triadic patent offices (European Patent Office (EPO), United States Patent and Trademark Office (USPTO), and Japan Patent Office (JPO)) between 2002 and 2005 and their citations made by the triadic offices, evidence shows that geographical distances negatively affect the probability of prior patents being caught in ISRs, while a lag of prior art positively affects the probability. Also, the technological complexity of an application negatively affects the probability, whereas the size of forward citations of prior art affects it positively. These results show the existence of cognitive restrictions borne by officials at the patent offices, and suggest issues for designing work sharing by patent offices, in that the duplication of search costs exists only where search horizons of patent offices overlap each other.
The Rickettsia-like Organisms TATLOCK (1943) and HEBA (1959): Bacteria Phenotypically Similar to but Genetically Distinct from Legionella pneumophila and the WIGA Bacterium

Two "rickettsia-like organisms," TATLOCK and HEBA, isolated from human blood via guinea pigs and embryonated eggs in 1943 and 1959, respectively, have been cultured on artificial media (charcoal yeast extract agar) for the first time and characterized. TATLOCK and HEBA have identical cultural, biochemical, and antigenic characteristics, as well as identical cellular fatty-acid composition and antimicrobial susceptibilities. These two bacteria have most of the cultural and biochemical characteristics of Legionella pneumophilia, and their gas-liquid chromatography cellular fatty-acid profile is similar to that of WIGA, another bacterium similar to L. pneumophila. Direct fluorescent-antibody reagents prepared for HEBA and TATLOCK gave equal high-titered reciprocal staining and were negative on 220 other bacteria, including L. pneumophila. Deoxyribonucleic acid relatedness studies, however, showed that these bacteria are not genetically related to either L. pneumophila or the WIGA bacterium.
Simple Techniques to enhance convergence of Integrals used in the Frequency Domain Moment Method for Rectangular Microstrip Antennas

Moment method in the spectral domain (SDA) is very popular for the analysis of microstrip antennas and offers some relative advantages in comparison with the space domain technique. Appropriate basis functions for microstrip antennas can be used to incorporate the qualitative nature of the true current distribution in the patch such as the edge condition. This eliminates the use of a large number of basis functions to accurately represent unknown current distributions. The SDA analysis for rectangular microstrip antennas normally requires a double infinite integration involving a product of two Bessel functions of order zero. This paper presents a new algorithm to directly perform this double infinite integration by using a simple technique to accelerate convergence of the integrand and an mW transformation to extrapolate its convergence. The new approach is found to be very efficient and easy to use, and is suitable to a variety of basis functions including mixed type basis functions sets. Other different structures can also benefit from this technique