Miracle-dz/UniFAR-FTUs huggingface dataset:
Abamectin exposure during lactation triggering oxidative stress and expression pattern of Bcl-2 perturbation in rat pups brain

Pesticides, for example, are thought to be essential drivers of brain injury and dysfunction. Abamectin (ABA) is by far the most routinely used pesticide in farming and healthcare, and its toxicity to nontarget organisms has attracted considerable interest. The effect of abamectin pesticide delivered at the postnatal period on the antioxidant defense system was assessed. This study also examined apoptotic gene expression indicators in the brains of rat pups over neonatal weeks. Pregnant Wister rats were split into two groups: G1 received deionized water (control), and G2 received 0.211 mg/L of abamectin. The first day of abamectin exposure was the first day after delivery and continued until the tenth day of lactation. After 10 days (mid lactation) and the lactation period, rat pup brain samples were taken for oxidative biochemistry investigations and apoptotic gene expression (RT–qPCR). In comparison to the control group G1, Abamectin reinforces protein carbonyl levels and glutathione-based enzymes (transferase and peroxidase), whereas superoxide dismutase and glutathione levels are reduced in the pup's brain. Furthermore, Abamectin induced considerable upregulation of proapoptotic (Bax) and antiapoptotic (Bcl-2) mRNA gene expression. Overall, our findings characterize the relationship between brain changes and abamectin administration during lactation periods, even at low doses that are considered safe, and indicate that this abamectin insecticide is harmful to the growing neurological system.
Fabrication of dimple structured surface of A390 Al-Si alloy using turning process

Purpose The purpose of this paper is to produce dimple structure on a cylindrical surface for Aluminium-Silicon (Al-Si) alloy piston (A390) using turning process. The process selection is based on factors such as the capability of machining process, low cost process, minimum set up time and green working environment. Design/methodology/approach Three main machining parameters that greatly influenced the dimple structure fabrication were identified from previous researches (cutting parameters, vibration and cutting tool geometry). To facilitate dimple structure fabrication using turning process, a dynamic assisted tooling (DATT) was developed. Experiments were conducted on Al-Si A390 material for future application of automotive piston. A three-dimensional surface profiler (Alicona) was used for geometry measurement and analysis of dimple structure. The Taguchi method, with an L8 orthogonal array, was used to accommodate seven parameters used in the fabrication of dimpled structures using turning process. Signal-to-noise (S/N) ratio and observation on the shape of dimple structure array were used to determine the optimum machining condition. Findings Optimum parameters obtained using S/N ratio analysis were cutting speed of 9 m/min, depth of cut of 0.01 mm, amplitude displacement of 1 mm, nose radius of 0.4 mm and frequency of (25 Hertz). Whereas feed rate, rake and relief angles were not significant to the size, shape and dimple array; therefore, their selected values depend on requirement of the application. Based on the S/N ratio and uniformity of the array of dimple structure as the main reference, the sixth and eighth experiment conditions almost achieved the optimum condition which are able to produce the width of dimple structure of 396.82 and 560.43 μm, respectively, dimple length of 3,261.6 and 2,422.7 μm, respectively, dimple depth of 63.43 and 65.97 μm, respectively, area ratio of 10 and 10.39 per cent, respectively, and surface roughness of 3.0023 and 3.0054 μm, respectively. These results are within the range of dimple structure obtained by the previous researchers for sliding mechanical components application. Originality/value The optimum condition of machining parameters in producing uniform dimple structure led to the compilation of data base in dimple structure research via turning process. Dimple structure produced is similarly obtained with other processes like laser, burnishing, photochemical, etc. DATT developed has the ability to produce repeatable vibration frequency, stable and consistent amplitude displacement using a simple crank concept and structure that can be mounted on all types of lathe machine either conventional or computer numerical control.
Screening and Validation of a Carvacrol-Targeting Viability-Regulating Protein, SLC6A3, in Liver Hepatocellular Carcinoma

Background Liver hepatocellular carcinoma (LIHC) is the second leading cause of tumor-related death in the world. Carvacrol was also found to inhibit multiple cancer types. Here, we proposed that Carvacrol inhibited LIHC. Methods We used MTT assay to determine the inhibition of Carvacrol on LIHC cells. BATMAN-TCM was used to predict targets of Carvacrol. These targets were further screened by their survival association and expression in cancer using TCGA data. The bioinformatic screened candidates were further validated in in vitro experiments and clinical samples. Finally, docking models of the interaction of Carvacrol and target protein were conducted. Results Carvacrol inhibited the viability of LIHC cell lines. 40 target genes of Carvacrol were predicted, 8 of them associated with survival. 4 genes were found differentially expressed in LIHC vs. normal liver. Among these genes, the expression of SLC6A3 and SCN4A was found affected by Carvacrol in LIHC cells, but only SLC6A3 correlated with the viability inhibition of Carvacrol on LIHC cell lines. A docking model of the interaction of Carvacrol and SLC6A3 was established with a good binding affinity. SLC6A3 knockdown and expression revealed that SLC6A3 promoted the viability of LIHC cells. Conclusion Carvacrol inhibited the viability of LIHC cells by downregulating SLC6A3.
Free-living protozoa (ciliophora, excavata and amoebozoa) in two water sources for human supply in the municipality of Blumenau, SC

The knowledge of the diversity of free-living protozoa in aquatic ecosystems represents an important tool in environmental quality management. It has been widely used in studies evaluating the water quality of fresh-water sources with environmental variables. Therefore, this study aimed to verify the diversity of free-living protozoa in two water sources used as a public supply for human consumption in the municipality of Blumenau, SC, for 12 months. Water samples were collected monthly for analysis of environmental variables and for identification of organisms. In total, 39 taxa were recorded in P1 and P2, both in the readings performed on the day of collection and in the cultivation. In P1, 11 taxa were identified in the readings of the day of collection, and after reading the cultivation, 20 new taxa were recorded. P2 presented 12 taxa in the readings performed on the day of collection and 10 new taxa in the cultivations' readings. Ciliates were the most expressive group in the period, with 69.5% frequency in P1 and 66.1% in P2. The results of the environmental variables in conjunction with the survey of the free-living protozoa of P1 and P2 did not show marked differences between the points. Still, they contributed to the knowledge of the diversity of protozoa in aquatic environments.
Linking quantities and symbols in early numeracy learning

What is the foundational knowledge that children rely on to provide meaning as they construct an exact symbolic number system? People and animals can quickly and accurately distinguish small exact quantities (i.e., 1 to 3). One possibility is that children’s ability to map small quantities to spoken number words supports their developing exact number system. To test this hypothesis, it is important to have valid and reliable measures of the efficiency of quantity-number word mapping. In the present study, we explored the reliability and validity of a measure for assessing the efficiency of mapping between small quantities and number words – speeded naming of quantity. Study 1 (N = 128) with 5- and 6-year-old children and Study 2 (N = 182) with 3- and 4-year-old children show that the speeded naming of quantities is a simple and reliable measure that is correlated with individual differences in children’s developing numeracy knowledge. This measure could provide a useful tool for testing comprehensive theories of how children develop their symbolic number representations.
A Turnkey Explainable AI System for AI Compliance in the Financial Sector

Although AI-driven predictive models have numerous benefits, organizations of all sizes struggle with AI adoption. This is due to the legal, ethical, and regulatory concerns that arise from the black-box behavior of these techniques, and the lack of easy-to-implement tools to mitigate those risks on an enterprise scale. This study addresses this problem by developing, applying, and evaluating a turnkey explainable AI system that supports compliance with AI regulations in the financial sector a heavily regulated industry. During an internship at a major Dutch insurance firm, we developed and deployed a system that combines multiple model-agnostic explainable AI techniques (including SHAP) under one interface, allowing the use of a single system to provide insights into the inner workings and fairness of any supervised learning model. In addition, the system is highly configurable and presents insights through an interactive report that is specifically tailored to serve a variety of stakeholders, from data scientists to compliance officers. We designed the system to support AI compliance and model refinement, and subsequently demonstrated these use cases and the system’s broad applicability by applying it to four production models. We performed an extensive evaluation to quantify the system’s effectiveness, and concluded that the system has a significant positive effect on participants’ model understanding, internal communication, and ability to assess model fairness. Additionally, the participants perceived this tool to be significantly more effective and easier to use compared to previously used tools. Finally, we present a procedure that prescribes how the system can be quickly and effectively implemented in other organizations. By enhancing the ethical use of AI and supporting compliance with AI regulations, this system removes various dominant hurdles for widespread AI adoption.
Weight Training for a Multilayer Perceptron: A Comparison Study

This paper presents a critical comparison of four optimisation algorithms for training a multilayer perceptron. The chosen algorithms are backpropagation, simulated annealing, genetic algorithms and Bayesian learning. We use a petroleum reservoir data set to compare the performance of these algorithms. The data set is randomly splitted into a training set and a test set. Error bounds are generated for all the test data. We use various statistics as performance indicators. The study shows that simulated annealing is the best algorithm for fast and efficient learning of the data set.
Fast and Lightweight Path Guiding Algorithm on GPU

We propose a simple, yet practical path guiding algorithm that runs on GPU. Path guiding renders photo-realistic images by simulating the iterative bounces of rays, which are sampled from the radiance distribution. The radiance distribution is often learned by serially updating the hierarchical data structure to represent complex scene geometry, which is not easily implemented with GPU. In contrast, we employ a regular data structure and allow fast updates by processing a signiﬁcant number of rays with GPU. We further increase the efﬁciency of radiance learning by employing SARSA [SB18] used in reinforcement learning. SARSA does not include aggregation of incident radiance from all directions nor storing all of the previous paths. The learned distribution is then sampled with an optimized rejection sampling, which adapts the current surface normal to reﬂect ﬁner geometry than the grid resolution. All of the algorithms have been implemented on GPU using megakernal architecture with NVIDIA OptiX [
M4D-MKLab/ITI-CERTH Participation in TREC Deep Learning Track 2021

Our team’s ( CERTH ITI M4D ) goal in the TREC Deep Learning Track was to study how the Con-textualized Embedding Query Expansion (CEQE) [1] method performs in such setting and how our proposed modifications affect the performance. In particular, we examine how CEQE performs with the addition of bigrams as potential expansion terms, and how an IDF weight component affects the performance. The first run we submitted is produced by a query expansion pipeline that uses BM25 for retrieval and CEQE with the IDF modification for query expansion. The second submitted run used a modification of CEQE with the addition of bigrams as candidate expansion terms and a re-ranking step using CEDR. Our runs showed promising results, especially for Average Precision.
Title : A G-lectin Receptor Kinase is a Negative Regulator of Arabidopsis Immunity 6 Against Root-Knot Nematode Meloidogyne incognita 7

Dongmei Zhou1,2*, Damaris Godinez-Vidal1*, Jiangman He1, Marcella Teixeira1, Jingzhe 8 Guo3, Lihui Wei2, Jaimie M. Van Norman3,4, Isgouhi Kaloshian1,3,4† 9 10 1Department of Nematology, University of California Riverside, CA 92521, USA. 11 2Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Key Lab of 12 Food Quality and Safety of Jiangsu Province, Nanjing 210014, China. 13 3Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of 14 California Riverside, CA 92521, USA. 15 4Department of Botany and Plant Sciences, University of California Riverside, CA 16 92521, USA. 17 18 19
Assess the Caregivers Burden, Stress and Coping Mechanism among Family Caregivers of Schizophrenic Patient – A Systematic Review

Introduction: Schizophrenia is a disabling, chronic mental disorder that gives rise to numerous challenges in its management and consequences. It exerts a significant cost of the patient in terms of personal suffering, on the caregivers a result of the shift of burden of care from hospital to families, and on society at large in term of significant direct and indirect cost that include frequent hospitalizations and need for long term psychological and economic support as well as life time last productivity. Aim and Objectives: This systematic review analyzes caregivers burden, stress and coping mechanism among family caregivers of Schizophrenic patients. Methods: The systematic review was conducted to determine caregivers burden, stress and coping mechanism in family caregivers of Schizophrenic patients. No date limitations were imposed for search. The National and International Journal, Pub Med, Google search databases were searched. The key words family caregivers burden, stress, coping were used as search terms. The study inclusion criteria were: study conducted with family caregivers of Schizophrenic patient. It exclusion criteria were : studies conducted with families caregivers of other than Schizophrenic. Results: Burden, The collective studies reveal that there was 31.6% mild burden, the prevalence of moderate burden is 48.1% and studies reveal that severe burden is prevalent in 15.6%, Stress, The overall result of studies showed that 52.5% is mild stress. Moderate stress prevails in 86% and severe stress is present in 14%, Co-relation, Collective studies reveal that higher the level of stress lower the coping strategies. r = –0.341, Mean Score: Studies reveal that the mean score of ZBI scale is 44.88.
Desain IPAL Komunal Limbah Domestik Perumahan Sukolilo Dian Regency dengan Teknologi Constructed Wetland

Constructed wetland merupakan sistem pengolahan terencana atau terkontrol yang telah didesain dan dibangun menggunakan proses alami yang melibatkan vegetasi, media, dan mikroorganisme untuk mengolah air limbah domestik. Constructed wetland cocok untuk diterapkan di perumahan, sehingga teknologi ini cocok menjadi alternatif pengolahan limbah domestik. Perumahan Sukolilo Dian Regency (SDR) merupakan salah satu perumahan yang belum memiliki IPAL untuk mengolah greywater, sehingga teknologi ini bisa diterapkan di perumahan ini untuk meningkatkan kualitas sanitasi lingkungan. Perencanaan sistem IPAL di Perumahan SDR mempertimbangkan aspek kuantitas dan kualitas air limbah domestik yang dihasilkan setiap harinya. Kualitas air limbah domestik menunjukkan nilai COD 320 mg/L; BOD 123 mg/L; dan TSS 60 mg/L. Sedangkan kuantitas air limbah menunjukan 453 m3/hari. Kemudian dilakukan analisis perhitungan masing-masing unit IPAL yang akan direncanakan di perumahan SDR agar sesuai dengan kriteria baku mutu pergub jatim no. 72 tahun 2013. Sistem IPAL direncanakan terdiri dari unit bak ekualisasi, Subsurface Flow Constructed Wetland dengan tanaman cattail, dan kolam indikator. Hasil perencanaan menunjukkan efisiensi pengolahan seluruh sistem untuk COD, BOD, dan TSS masing-masing sebesar 86%, 80%, dan 46%, dengan efisiensi tersebut effluent limbah cari IPAL telah memenuhi baku mutu yang ditentukan. Biaya investasi seluruh sistem constructed wetland diperkirakan sebesar Rp 5.313. 310.000. Perencanaan ini menghasilkan panduan untuk operasional dan perawatan.
Analysis and Design of Single-Point Fed Transmission Line Grid 2D Dirac Leaky-Wave Antennas

Analysis and Design of Single-Point Fed Transmission Line Grid 2D Dirac Leaky-Wave Antennas Ayman Hassen Dorrah Master’s of Applied Science Graduate Department of Electrical & Computer Engineering University of Toronto 2016 Leaky-wave antennas (LWAs) are widely used as single-point fed linear antenna arrays. The extension of LWAs to 2D means that they can be used as single-point fed 2D antenna arrays without requiring a complex feeding network. However, generating a pencil beam from 2D LWAs is not straightforward and due care has to be given to the LWA design. On the other hand, transmission line (TL) grids have demonstrated interesting behaviors, such as negative refractive index and growing of evanescent waves. In this thesis, single-point fed TL-grid 2D LWA designs are proposed that can generate pencil beams at both broadside and tilted angles. The TL-grid is analytically treated in light of the eigenmodes of the TL-grid unit cell, the scattering and impedance parameters and 2D dispersion relation. Additionally, TL-grids are shown to inherently exhibit an open bandgap in the dispersion relation and the TL-grid is perturbed to close this bandgap.
E-commerce Store with Augmented Reality Features

: Augmented reality as a technology is itself quite a new trend in the Tech world and the integration of this technology with the Ecommerce sector is a relatively less explored field. Currently, our Ecommerce sector is not capable of providing a virtual experience to the customers but with the help of Augmented Reality, we can eliminate this problem and elevate the user experience by creating a completely new way for users to interact with the Ecommerce websites. The next revolution in the Ecommerce sector will be with the help of Augmented Reality (AR) technology as more and more customers would want a shopping experience that is tailored to their personal preferences and AR is one such technology that is capable of providing such experience to the customers. In this work we have explored how augmented reality when fused with the Ecommerce sector will affect the new age shoppers, for studying this we have created an Ecommerce web application with augmented reality features, this web application is capable of augmenting 3D models of the products available on the website onto the real-time environment thus creating a completely new user experience.
Brains as Computers: Metaphor, Analogy, Theory or Fact?

Whether electronic, analog or quantum, a computer is a programmable machine. Wilder Penfield held that the brain is literally a computer, because he was a dualist: the mind programs the brain. If this type of dualism is rejected, then identifying the brain to a computer requires defining what a brain “program” might mean and who gets to “program” the brain. If the brain “programs” itself when it learns, then this is a metaphor. If evolution “programs” the brain, then this is a metaphor. Indeed, in the neuroscience literature, the brain-computer is typically not used as an analogy, i.e., as an explicit comparison, but metaphorically, by importing terms from the field of computers into neuroscientific discourse: we assert that brains compute the location of sounds, we wonder how perceptual algorithms are implemented in the brain. Considerable difficulties arise when attempting to give a precise biological description of these terms, which is the sign that we are indeed dealing with a metaphor. Metaphors can be both useful and misleading. The appeal of the brain-computer metaphor is that it promises to bridge physiological and mental domains. But it is misleading because the basis of this promise is that computer terms are themselves imported from the mental domain (calculation, memory, information). In other words, the brain-computer metaphor offers a reductionist view of cognition (all cognition is calculation) rather than a naturalistic theory of cognition, hidden behind a metaphoric blanket.
Received Power Characterization of Terrestrial Cellular Signals on High Altitude Aircraft

The received power of terrestrial cellular 3G code division multiple access (CDMA) and 4G long-term evolution (LTE) signals on a high altitude aircraft is experimentally characterized. The conducted experiments were performed on a Beechcraft C-12 Huron, a fixed-wing U.S. Air Force aircraft. Two types of flight patterns were performed: (i) teardrop-like patterns to characterize the carrier-to-noise ratio $(C/N_{0})$ versus altitude and (ii) grid-like patterns to characterize $C/N_{0}$ versus the horizontal distance between the aircraft and cellular towers. Flight campaigns in two regions were conducted: (i) a rural region in Edwards, California, USA, and (ii) an urban region in Riverside, California, USA. It was observed that cellular signals are surprisingly powerful at both (i) high altitudes, exhibiting $C/N_{0}$ of 25–55 dB-Hz at altitudes of 2,000-23,000 ft above ground level (AGL) and (ii) faraway horizontal distances, exhibiting $C/N_{0}$ of about 30 dB-Hz for towers as far as 50 km, while flying at about 16,000 ft AGL. In addition, two propagation models were evaluated to describe the behavior of the measured $C/N_{0}$: (i) free-space path loss model and (ii) two-ray model. It was observed that the two-ray model fits the measured $C/N_{0}$ sufficiently well, for towers more than 10 km away, while flying at an altitude of 16,000 ft AGL. For towers closer than 10 km, the antenna radiation pattern should be incorporated into the two-ray model to improve model fitting.