Miracle-dz/UniFAR-FTUs huggingface dataset:
Preference for complementary and alternative medicine among patients on long-term treatment in Jos university teaching hospital, Nigeria

Background: The use of complementary and alternative medicines(CAM) is on the increase globally particularly among those with chronic medical conditions. Imperatively, the treatment outcomes of management of chronic illness is hinged on adherence to prescribed conventional treatment with little or no attention paid to the intent to use or concomitant use of alternative medicines in most treatment settings. Hence, this study assessed the preference for CAM and its predictors as among patients on long-term treatment in Jos University Teaching Hospital. Methods: This was a cross-sectional study conducted among 176 patients accessing treatment for chronic medical conditions in Jos University Teaching Hospital using quantitative method of data collection. Epi Info statistical software version 7 was used for data analysis with odds ratio and 95% confidence interval used as point and interval estimates respectively while a P-value of <0.05 was considered statistically significant. Results: The median age of respondents was 50 (IQR 30–84) years with 83 (47.2%) being 51 years and above. Preference for CAM was reported by 26 (14.8%) with absence of side effects (AOR = 11.3; 95% CI= 5.8299–15.1185) being the sole predictor of preference for CAM. Conclusion: This study has demonstrated some level of preference for CAM among patients on long term conventional treatment with perceived absence of side effects influencing this preference level.
Association Between Anxiety and New Organ Failure, Independently of Critical Illness Severity and Respiratory Status: A Prospective Multicentric Cohort Study

Supplemental Digital Content is available in the text. Objectives: Anxiety results from the anticipation of a threat and might be associated with poor outcome in the critically ill. This study aims at showing that anxiety at admission in critically ill patients is associated with new organ failure over the first 7 days of ICU hospitalization independently of baseline organ failure at admission. Design: Prospective multicenter cohort study. Setting: Three mixed ICU from April 2014 to December 2017. Patients: Coma-, delirium-, and invasive mechanical ventilation-free patients admitted to the ICU were included. Interventions: None. Measurements and Main Results: “State anxiety” was assessed using the state component of the State-Trait Anxiety Inventory State. Severity of illness was measured using Simplified Acute Physiology Score II and Sequential Organ Failure Assessment scores. Primary endpoint was a composite of occurrence of death or new organ failure in the first 7 days after admission. Three hundred ninety-one patients were included; 159 of 391 women (40.7%); median age 63 years (49–74 yr); median Simplified Acute Physiology Score II 28 (19–37). Two hundred three out of 391 patients (51.9%) reported moderate to severe anxiety (State-Trait Anxiety Inventory State ≥ 40). One hundred two out of 391 patients (26.1%) developed a new organ failure. After adjustment to Simplified Acute Physiology Score II and Sequential Organ Failure Assessment, State-Trait Anxiety Inventory State greater than or equal to 40 was associated with the primary endpoint (odds ratio, 1.94; 95% CI, 1.18–3.18; p = 0.009) and respiratory failure. In post hoc analysis, State-Trait Anxiety Inventory State greater than or equal to 40 was associated with new organ failure independently and notably of respiratory status at admission (dyspnea-Visual Analogic Scale and Paco2 ≥ 45 mm Hg). Conclusions: Moderate to severe anxiety at ICU admission is associated with early occurrence of new organ failure in critically ill patients, independently of respiratory status and severity of critical illness. The causality link could be addressed in an interventional trial.
Real-Time Height Measurement for Moving Pedestrians

Height measurement for moving pedestrians is quite significant in many scenarios, such as pedestrian positioning, criminal suspect tracking, and virtual reality. Although some existing height measurement methods can detect the height of the static people, it is hard to measure height accurately for moving pedestrians. Considering the height fluctuations in dynamic situation, this paper proposes a real-time height measurement based on the Time-of-Flight (TOF) camera. Depth images in a continuous sequence are addressed to obtain the real-time height of the pedestrian with moving. Firstly, a normalization equation is presented to convert the depth image into the grey image for a lower time cost and better performance. Secondly, a difference-particle swarm optimization (D-PSO) algorithm is proposed to remove the complex background and reduce the noises. Thirdly, a segmentation algorithm based on the maximally stable extremal regions (MSERs) is introduced to extract the pedestrian head region. Then, a novel multilayer iterative average algorithm (MLIA) is developed for obtaining the height of dynamic pedestrians. Finally, Kalman filtering is used to improve the measurement accuracy by combining the current measurement and the height at the last moment. In addition, the VICON system is adopted as the ground truth to verify the proposed method, and the result shows that our method can accurately measure the real-time height of moving pedestrians.
A comparison of photosynthesis measurements by O 2 evolution, 14 C assimilation, and variable chlorophyll fluorescence during light acclimatization of the diatom Coscinodiscus granii

Copyright © 2015 The Korean Society of Phycology 103 http://e-algae.kr pISSN: 1226-2617 eISSN: 2093-0860 A comparison of photosynthesis measurements by O2 evolution, 14C assimilation, and variable chlorophyll fluorescence during light acclimatization of the diatom Coscinodiscus granii Erik Trampe*, Per Juel Hansen and Michael Kuhl Marine Biological Section, Department of Biology, University of Copenhagen, Strandpromenaden 5, DK-3000 Helsingor, Denmark Plant Functional Biology and Climate Change Cluster, University of Technology Sydney, PO Box 123, Ultimo Sydney NSW 2007, Australia
The Movement and Migration of Shrimp, Penaeus semisulcatus in Bushehr Coastal Waters, Persian Gulf

The pattern of movement of green tiger prawn, Penaeus semisulcatus, was carried out in Bushehr waters, Persian Gulf, in 2003 and 2004. During this experiment 2571 shrimps, P. semisulcatus were tagged with green polyethylene steamer tags and released at sea from January 2003 to July 2004. During the open season of shrimps (August and September), 68 shrimps were recaptured but four of the recaptures were excluded due to inconstancies of information. The direction of movement of recaptures was mostly to the north west of the release area and to deeper waters. The majority of recaptures exhibited speed of less than 2 km/day and maximum speed was recorded at 3-4 km/day. The longest distance of 127 km was performed by a female during 95 days liberty. In the Persian Gulf the main of sea current is from the Strait of Hormuz to the Iranian waters, and probably influences the pattern of shrimp movement in the Bushehr area.
Do Environmental Regulations Affect the Decision to Export?

This paper investigates how a common form of environmental regulation—air quality standards—affects exporters. We develop a simple theoretical model to show how the design of these standards causes (i) some firms to stop exporting and (ii) a reduction in the export volumes of affected continuing exporters. We exploit quasi-experimental variation resulting from the design of Canadian air quality standards to test these predictions empirically. Our estimates confirm our model’s predictions: we find that for the most affected manufacturers, regulation reduced export volumes by 32 percent and increased the likelihood plants stop exporting by 5 percentage points. (JEL D12, F14, F18, Q53, Q58)
Glucocorticoid receptor expression in multiple myeloma patients is a predictor of survival

Abstract Multiple myeloma (MM) is a blood neoplasia characterized by abnormal proliferation of plasma cells. Various treatments such as stem cell transplant (SCT), proteasome inhibitors, immune-modulating drugs, monoclonal antibodies and selective inhibitors of nuclear export have been routinely used to treat MM. However, relapse and treatment resistance are common problems in MM patients. Treatments are enhanced by Dexamethasone (Dex), a synthetic steroid that activates the glucocorticoid receptor (GR) which leads to apoptosis. To evaluate the potential impact of GR expression on overall survival, MM patient data from the CoMMpass study of 650 patients were analyzed. Multivariate modeling results show that increased GR expression at diagnosis is associated with a decreased risk of dying relative to those with lower levels of expression.
Functional connectivity network estimation with an inter-similarity prior for mild cognitive impairment classification

Functional connectivity network (FCN) analysis is an effective technique for modeling human brain patterns and diagnosing neurological disorders such as Alzheimer’s disease (AD) and its early stage, Mild Cognitive Impairment. However, accurately estimating biologically meaningful and discriminative FCNs remains challenging due to the poor quality of functional magnetic resonance imaging (fMRI) data and our limited understanding of the human brain. Inspired by the inter-similarity nature of FCNs, similar regions of interest tend to share similar connection patterns. Here, we propose a functional brain network modeling scheme by encoding Inter-similarity prior into a graph-regularization term, which can be easily solved with an efficient optimization algorithm. To illustrate its effectiveness, we conducted experiments to distinguish Mild Cognitive Impairment from normal controls based on their respective FCNs. Our method outperformed the baseline and state-of-the-art methods by achieving an 88.19% classification accuracy. Furthermore, post hoc inspection of the informative features showed that our method yielded more biologically meaningful functional brain connectivity.
Clinicopathological and prognostic significance of BCL2, BCL6, MYC, and IRF4 copy number gains and translocations in follicular lymphoma: a study by FISH analysis

Abstract BCL2 translocation is the genetic hallmark of follicular lymphoma (FL). Besides BCL2 translocation, copy number (CN) gains and translocations of BCL6, MYC, and IRF4 have also been detected in FL, but there is little information regarding their prognostic significance. This retrospective study used fluorescence in situ hybridization (FISH) to analyze BCL2, BCL6, MYC, and IRF4 translocations and CN gains in 105 FL cases. Genetic translocations were detected for BCL2 (n = 64; 72.7%), BCL6 (n = 14; 15.9%), and MYC (n = 2; 2.3%); no case showed IRF4 translocation. Overall, 23 (26.1%), 30 (34.1%), 12 (13.8%), and 10 (11.0%) cases showed CN gains in BCL2, BCL6, MYC, and IRF4, respectively. BCL6 CN gain was a prognostic factor for worse overall survival, demonstrating a trend toward significance in multivariate analysis (HR =8.769, p = 0.056). BCL6 CN gain in FL might be associated with aggressive biologic behavior.
Fsp1 cardiac embryonic expression delineates atrioventricular endocardial cushion, coronary venous and lymphatic valve development

Fsp1 (a.k.a S100A4 or Metastatin) is an intracellular and secreted protein widely regarded as a fibroblast marker. Recent studies have nonetheless shown that Fsp1 is also expressed by other cell types, including small subsets of endothelial cells. Since no detailed and systematic description of Fsp1 spatio‐temporal expression pattern in cardiac vascular cells is available in the literature, we have used a transgenic murine line (Fsp1‐GFP) to study Fsp1 expression in the developing and postnatal cardiac vasculature and endocardium. Our work shows that Fsp1 is expressed in the endocardium and mesenchyme of atrioventricular valve primordia, as well as in some coronary venous and lymphatic endothelial cells. Fsp1 expression in cardiac venous and lymphatic endothelium is progressively restricted to the leaflets of cardiac venous and lymphatic valves. Our results suggest that Fsp1 could play a role in the development of atrioventricular valves and participate in the patterning and morphogenesis of cardiac venous and lymphatic vessel valves.
Digital Behavioral Phenotyping Detects Atypical Pattern of Facial Expression in Toddlers with Autism

Commonly used screening tools for autism spectrum disorder (ASD) generally rely on subjective caregiver questionnaires. While behavioral observation is more objective, it is also expensive, time‐consuming, and requires significant expertise to perform. As such, there remains a critical need to develop feasible, scalable, and reliable tools that can characterize ASD risk behaviors. This study assessed the utility of a tablet‐based behavioral assessment for eliciting and detecting one type of risk behavior, namely, patterns of facial expression, in 104 toddlers (ASD N = 22) and evaluated whether such patterns differentiated toddlers with and without ASD. The assessment consisted of the child sitting on his/her caregiver's lap and watching brief movies shown on a smart tablet while the embedded camera recorded the child's facial expressions. Computer vision analysis (CVA) automatically detected and tracked facial landmarks, which were used to estimate head position and facial expressions (Positive, Neutral, All Other). Using CVA, specific points throughout the movies were identified that reliably differentiate between children with and without ASD based on their patterns of facial movement and expressions (area under the curves for individual movies ranging from 0.62 to 0.73). During these instances, children with ASD more frequently displayed Neutral expressions compared to children without ASD, who had more All Other expressions. The frequency of All Other expressions was driven by non‐ASD children more often displaying raised eyebrows and an open mouth, characteristic of engagement/interest. Preliminary results suggest computational coding of facial movements and expressions via a tablet‐based assessment can detect differences in affective expression, one of the early, core features of ASD.
ASYMMETRIC HYBRIDIZATION AND SEX-BIASED GENE FLOW BETWEEN EASTERN SPOT-BILLED DUCKS (ANAS ZONORHYNCHA) AND MALLARDS (A. PLATYRHYNCHOS) IN THE RUSSIAN FAR EAST

A�������. —The Eastern Spot-billed Duck (Anas zonorhyncha) historically was rare in the southern Russian Far East. However, during the last 60–70 years, its breeding range in East Asia has expanded northwest; Eastern Spot-billed Ducks are breeding increasingly within the range of Mallards (A. platyrhynchos). We collected 120 Eastern Spot-billed Ducks and Mallards from Primorye, Russia, and sequenced 666–667 base pairs (bp) of the maternally inherited mitochondrial DNA (mtDNA) control region and 255 bp of the ornithine decarboxylase intron six (ODC6). Control region and ODC-6 allele sequences revealed two divergent groups of haplotypes and alleles that diff er by 1.5% and 2.0%, respectively, and correspond to Avise et al.’s (1990) group A and B mtDNA haplotypes. Group A mtDNA haplotypes occurred in 22 Eastern Spot-billed Ducks and 78 Asian Mallards, and group B haplotypes occurred in 14 Eastern Spot-billed Ducks and 4 Asian Mallards. Moreover, the group B haplotypes that we observed predominantly in Eastern Spot-billed Ducks (i.e. group SB) were monophyletic and diverged by 2–16 substitutions
The Effects of Beef Muscle Variety on Beef Aging Indices

牛肉の熟度指標に及ぼす筋肉部位の影響を調べるためにご,屠殺後3日のホルスタイン種去勢牛のウデ肉から4種の筋肉(上腕三頭筋(TB),棘上筋(SS),上腕二頭筋(BB)上腕筋(BA))を採取し,ポリ塩化ビニリデンフィルムで真空包装した. これを0°Cで28日間貯蔵し,貯蔵開始当日(死後4日),7,14,21,および28日目に分析した. 分析は供試筋肉のコラーゲン含量と貯蔵中の筋肉の官能的柔らかさ,剪断力価(SFV),ATP関連化合物,筋原線維小片化率(MFI),および30,000ダルトン成分(34kDa)の変化を調べた. 全コラーゲン量は筋肉間で異なり,多い順にBA>BB>SS>TB筋となった. 官能的柔らかさはいずれの筋肉も貯蔵日数の進行と共に向上し,貯蔵による熟成の効果が認められた. 軟化の程度はコラーゲン量の多いBA筋で少なかった. 貯蔵中のMFIの増加速度は筋肉間で異なり,コラーゲン量が多い筋肉(BB, BA)ほど遅い傾向にあった. 30kDaはMFIの進行が速い筋肉で貯蔵中に増加傾向にあったが,その程度は前報8)のロース肉に比べ少なかった. 逆にMFIの進行が遅い筋肉では30kDaの出現時期は遅く,貯蔵中の増加もわずかであった. このように30kDaの発現と筋原線維の小片化との間に強い関係が見られた. これらの特性に対し,ATP関連化合物の貯蔵中の変動パターンはどの筋肉でもほとんど同じで,上述の筋肉間の軟化の差異に対応せず,軟化速度の遅い筋肉に対しては熟度指標として好ましくなかった. 以上から,牛肉の熟度指標として,ATP関連化合物よりもSFV, MFIおよび30kDaの方が有効と考えられた.
Clinical spectrum and diagnosis of diabetic neuropathies

Neuropathy is the most prevalent microvascular complication of diabetes mellitus; it encompasses distal symmetric polyneuropathy, autonomic neuropathy, radiculoplexus neuropathy, mononeuropathy, and treatment-induced neuropathy. The prevalence rate of diabetic neuropathy in Korea was reported to be approximately 43%, which is similar to rates in other countries. However, the precise pathogenic mechanism underlying diabetic neuropathy is still obscure, and many clinical trials have failed to develop methods to prevent or reduce the progression of diabetic neuropathy. Nevertheless, early diagnosis and proper management of diabetic neuropathy are essential to alleviate disabling symptoms and to improve the quality of life of patients. This review discusses clinical manifestations and classification of diabetic neuropathies, bedside neurological examination, and electrophysiological tests.
The 4D B-spline method of calculating left ventricular functional parameters of cardiac MRI to evaluate myocardial injury of the apical segment in patients with myocarditis: a case-controlled observational study.

Background Myocarditis does not have typical clinical manifestations and thus is difficult to accurately diagnose by virtue of infection history, and electrocardiogram (EKG) and peripheral blood abnormalities. Endomyocardial biopsy is the gold standard for diagnosis of myocarditis, but is invasive, high risk, and has an observational blind area. Cardiac magnetic resonance imaging (CMRI) is multiparameter and multidirectional with high spatial resolution and high contrast of soft tissue. However, the optimal method of calculating left ventricular (LV) function in patients with apical-segment-injured myocarditis is unresolved. We compared and analyzed the differences between two different methods (Simpson and 4D B-spline surface model (known as the 4D method)) of measuring LV function by CMRI in patients with myocarditis in the 17th segment of the left ventricle. Methods The basic clinical data of two groups (myocarditis and non-myocarditis) were statistically analyzed, and differences in the LV function parameters by the two imaging methods were compared in the myocarditis group. Receiver-operating characteristic curves of single parameters and combined parameters based on the Simpson and 4D methods were drawn and the area under the curve, diagnostic threshold, maximum sensitivity interval, and maximum specificity interval were calculated. Results In the myocarditis and non-myocarditis groups the respective number of patients was 22 and 17, the percentage of males was 54.55% and 47.06%, and the average age was 32.20±11.59 and 43.06±11.62 years. The difference in LV ejection fraction (LVEF) (P=0.033) and LV end systolic volume (LVESV) (P=0.030) in the myocarditis group was statistically significant. The respective AUCs based on the Simpson and 4D methods were LVEF 0.602 vs. 0.778, LVESV 0.556 vs. 0.751, LVEF-and-LVESV 0.634 vs. 0.775. Based on the 4D method, the diagnostic thresholds of LVEF and LVESV were 34.965 (sensitivity 0.882, specificity 0.591) and 69.090 (sensitivity 0.727, specificity 0.706), the maximum sensitivity intervals of LVEF and LVESV were (24.610, 27.450) and (35.355, 37.200), and the maximum specificity intervals of LVEF and LVESV were (60.530, 65.625) and (91.625, 95.835), respectively. Conclusions Compared with the Simpson method, the 4D method might be more effective for CMRI diagnosis of apical-segment-injured myocarditis. When the Simpson method is used, LVEF combined with LVESV is recommended for comprehensive evaluation to improve diagnostic efficiency. When the 4D method is used, LVEF might be the preferred parameter for evaluation of LV function.
Guidelines for Nonvariceal Upper Gastrointestinal Bleeding

Nonvariceal upper gastrointestinal bleeding (NVUGIB) refers to bleeding that develops in the gastrointestinal tract proximal to the ligament of Treitz. NVUGIB requires hospitalization and is associated with significant morbidity and mortality. Although European and Asian-Pacific guidelines have been published, there have been no previous guidelines regarding management of NVUGIB in Korea. Korea has a high prevalence of Helicobacter pylori infections, and patients have easy accessibility to endoscopy. Therefore, we believe that guidelines regarding management of NVUGIB in Korea are essential. The Korean Society of Gastroenterology reviewed the recent evidence and recommends practical management guidelines on NVUGIB in Korea.
PEBP1 suppresses HIV transcription and induces latency by inactivating MAPK/NF‐κB signaling

The latent HIV‐1 reservoir is a major barrier to viral eradication. However, our understanding of how HIV‐1 establishes latency is incomplete. Here, by performing a genome‐wide CRISPR‐Cas9 knockout library screen, we identify phosphatidylethanolamine‐binding protein 1 (PEBP1), also known as Raf kinase inhibitor protein (RKIP), as a novel gene inducing HIV latency. Depletion of PEBP1 leads to the reactivation of HIV‐1 in multiple models of latency. Mechanistically, PEBP1 de‐phosphorylates Raf1/ERK/IκB and IKK/IκB signaling pathways to sequestrate NF‐κB in the cytoplasm, which transcriptionally inactivates HIV‐1 to induce latency. Importantly, the induction of PEBP1 expression by the green tea compound epigallocatechin‐3‐gallate (EGCG) prevents latency reversal by inhibiting nuclear translocation of NF‐κB, thereby suppressing HIV‐1 transcription in primary CD4+ T cells isolated from patients receiving antiretroviral therapy (ART). These results suggest a critical role for PEBP1 in the regulation of upstream NF‐κB signaling pathways governing HIV transcription. Targeting of this pathway could be an option to control HIV reservoirs in patients in the future.