Miracle-dz/UniFAR-FTUs huggingface dataset:
Simulation in cardiology : state of the art

Simulation is the technique of imitating a process or situation for education, training, modelling of an uncommon or risky scenario, or testing systems when new elements are introduced (such as a new protocol). Simulation training is not new to medicine. Anatomical models were created in ancient times, and in the 1960s the Norwegian toy manufacturer Laerdal pioneered simulation to practise cardiopulmonary resuscitation and critical event drills. Early models were crude, but they were widely adopted. The HARVEY cardiovascular simulator was one of the first manikins developed which was computer driven and provided replication of anatomy with palpable pulses and auscultatable areas. This allowed medical students to experience some of the findings from clinical examination for the first time in a standardized setting. More recently, with advances in technology, there has been a rapid expansion in simulating other aspects of healthcare, with increasing sophistication. Modern computing power allows the recreation of complex anatomical and physiological systems programmed to respond to inputs from the user. There have also been advances in manikins and devices to physically replicate the steps of performing complex procedures. Fidelity is the degree of accuracy with which a simulation replicates a clinical scenario. This is defined in terms of the realism of the environment in which the simulation takes place, the equipment used and the psychological engagement of the learner. It is not necessarily synonymous with the technology of the simulator. Indeed, evidence suggests that the indiscriminate use of high-technology simulators alone is unlikely to be more effective than other methods. The ability to use realistic clinical environments (or practice in situ), using equipment which closely replicates the look, feel and feedback of clinical situations will facilitate the immersion of the learner into the simulation, but it is important to consider their emotional response and behaviour. There is little to be gained if the learner reacts in an artificial manner, or is encouraged to perform risky actions as a result of a lack of engagement. This may result in the learning of poor practice, or a failure to achieve the intended learning. This lack of psychological engagement may be as a result of a scepticism towards the use of simulation or unfamiliarity with the process, including anxiety related to audio–video recordings. Thoroughbriefing prior to simulations, with an introduction to the equipment and environment used, what to expect, and what capabilities the simulators do not have will help to alleviate some of these issues.
Financing Corporate Tax Cuts with Shareholder Taxes Working Paper 2018-08

We study the aggregate and distributional consequences of replacing corporate pro t taxes with shareholder taxes, namely, taxes on dividends and capital gains, in a setting with incomplete markets and heterogeneity at both the household and the rm level. The reform yields distributional gains with a large majority of households bene ting. Moreover, if dividend and capital gains are taxed at the same rate, the reform is also e¢ ciencyenhancing and the implied optimal corporate income tax rate is zero. In contrast, an asymmetric tax treatment of dividend and capital gains induces a trade-o¤ between e¢ ciency and distributional concerns that is optimally resolved at a positive optimal corporate tax rate, implying double taxation. JEL classi cation: E6 Keywords: Optimal corporate taxes; Optimal Shareholder Taxes; Double taxation; Heterogeneity; Misallocation. This paper was previously circulated under the title "On the Double Taxation of Corporate Pro ts". We wish to thank Arpad Abraham, Juan Carlos Conesa, Allan Drazen, Ayse Imrohoroglu, Ayse Kabukcuoglu, Andrea Lanteri, Han Ozsoylev, Joseph Zeira as well as seminar participants at the EUI, Koc, Southampton, St. Andrews, Sabanci, Bilgi and Bogazici Universities and conference participants at the Midwest Macro, SED, CRETE and North American Summer meetings for helpful comments and suggestions. yEmail: alexis.anagnostopoulos@stonybrook.edu. zEmail: erem.atesagaoglu@bilgi.edu. tr xEmail: ecarcelespov@gmail.com.
Kobe University Repository : Kernel タイトル Tit le Fast Training of Support Vector Machines by Extract ing Boundary Data 著者

Support vector machines have gotten wide acceptance for their high generalization ability for real world applications. But the major drawback is slow training for classification problems with a large number of training data. To overcome this problem, in this paper, we discuss extracting boundary data from the training data and train the support vector machine using only these data. Namely, for each training datum we calculate the Mahalanobis distances and extract those data that are misclassified by the Mahalanobis distances or that have small relative differences of the Mahalanobis distances. We demonstrate the effectiveness of the method for the benchmark data sets.
Striatins as plaque molecules of zonulae adhaerentes in simple epithelia , of tessellate junctions in stratified epithelia , of cardiac composite junctions and of various Citation

Proteins of the striatin family (striatins 1–4; sizes ranging from 90 to 110 kDa on SDS-polyacrylamide gel electrophoresis) are highly homologous in their amino acid sequences but can differ in their cell-type-specific gene expression patterns and biological functions. In various cell types, we have found one, two or three polypeptides of this evolutionarily old and nearly ubiquitous family of proteins known to serve as scaffold proteins for diverse protein complexes. Light and electron microscopic immunolocalization methods have revealed striatins in mammalian cellcell adherens junctions (AJs). In simple epithelia, we have localized striatins as constitutive components of the plaques of the subapical zonulae adhaerentes of cells, including intestinal, glandular, ductal and urothelial cells and hepatocytes. Striatins colocalize with E-cadherin or E–N-cadherin heterodimers and with the plaque proteins αand β-catenin, p120 and p0071. In some epithelia and carcinomas and in cultured cells derived therefrom, striatins are also seen in lateral AJs. In stratified epithelia and in corresponding squamous cell carcinomas, striatins can be found in plaques of some forms of tessellate junctions. Moreover, striatins are major plaque proteins of composite junctions (CJs; areae compositae) in the intercalated disks connecting cardiomyocytes, colocalizing with other CJ molecules, inc luding plec t in and ankyr in-G. We discuss the “multimodulator” scaffold roles of striatins in the initiation and regulation of the formation of various complex particles and structures. We propose that striatins are included in the diagnostic candidate list of proteins that, in the CJs of human hearts, can occur in mutated forms in the pathogeneses of hereditary cardiomyopathies, as seen in some types of genetically determined heart damage in boxer dogs.
Quantifying the Losses from International Trade

This paper studies the welfare losses associated with exposure to international import competition. Empirically, we construct a measure of consumption at the local labor market level in the US, and exploit regional variation in exposure to imports from China in the early 2000s to study the response of consumption to trade shocks. We interpret this evidence within a standard incomplete market model with Ricardian trade across countries. The model features several mechanisms of partial insurance against adverse shocks to comparative advantage: self-insurance, variable labor supply, and migration. We calibrate model to match the observed consumption and labor market response (as measured in David, Dorn, and Hanson (2013)) to Chinese import competition and then quantify how much the losers from trade actually lost.
Germplasm Resources for MappingQuantitative Traits in Maize

The expression of quantitative traits is complex, often the result of multiple genes acting in concert, and interacting with the environment. Determining the genetic control of quantitative traits can be accomplished using a number of methods to link genotype to phenotype, such as linkage-based quantitative trait locus (QTL) mapping, genome-wide association mapping (GWAS), and multi-parent mapping including nested association mapping (NAM) and multi-parent advanced generation intercrosses (MAGIC). A wide array of germplasm resources are available for mapping QTL in maize. The purpose of this chapter is to provide a brief overview of QTL mapping methods, to provide background about commonly used germplasm resources, and to discuss the strengths and weakness of each. 10.
IMPLICATIONS IN THE PHILOSOPHY OF SCIENCE FROM THE USE OF ARTIFICIAL NEURAL NETWORKS

The technological advance allowed new artificial intelligence algorithms to emerge. Among the new models, those of artificial neural networks are presented as one of the most disseminated, due to their accuracy in the prediction. However, this type of algorithm is commonly called the "black box", by using multiple obscure layers, rendering its logic-mathematical inaccessible and generating problems that affect the philosophy of science. The purpose of this paper is to present epistemological problems that emerge from the use of artificial intelligence and, more specifically, the artificial neural network (ANN) method.
IFRD 1 gene polymorphisms are associated with nasal polyposis in cystic fibrosis patients *

Background: Nasal polyposis (NP) is an inflammatory disease of the upper nasal airways frequently present in CF patients. Interferon-Related Developmental Regulator 1 (IFRD1) gene was reported as a possible modifier of CF lung disease severity. Three IFRD1 SNPs were analyzed to investigate a possible effect on the development of NP in CF patients. Methods and Patients: The DNA of 143 patients with CF (40 with and 103 without NP) was purified from peripheral blood samples. IFRD1 SNPs (rs7817, rs3807213, rs6968084) were genotyped by restriction enzyme analysis. Results: The T allele of the common polymorphism rs7817 and the rs7817-rs3807213 haplotype were associated with NP (p=0.002 and 0.004 respectively). Conclusions: These results showed the association of the IFRD1-rs7817 polymorphism with NP in CF patients.
Edinburgh Research Explorer Benchmarking for power consumption monitoring

This paper presents a set of benchmarks that are designed to measure power consumption in parallel systems. The benchmarks range from low-level, single instructions or operations, to small kernels. In addition to describing the motivation behind developing the benchmarks and the de-sign principles that were followed, the paper also introduces a metric to quantify the power-performanceof a parallel sys-tem. Initial results are presented and help to illustrate the contribution of the paper.
Exploring the utility of three plastid loci for biocoding the filmy ferns (Hymenophyllaceae) of Moorea

The Moorea Biocode seeks to compile an integrative taxonomy based on morphological, ecological, and molecular data for the entire macrobiota of the island of Moorea, French Polynesia. As a case study exploring the utility of selected molecular data for species identification within this integrative taxonomic framework, chloroplast DNA from three regions (rbcL, trnSGG, trnH-psbA) were sequenced for all species of filmy ferns (Hymenophyllaceae) known from Moorea. The relative utility of each of these regions for the purposes of phylogenetic analysis and DNA-based identification was inferred by estimating support for phylogenetic trees reconstructed from each region and by calculating intraspecific and interspecific distance values (uncorrected p) between taxa for each region. All three of these regions were found to be potentially useful for phylogenetic studies at the appropriate taxonomic level. trnH-psbA was determined to have the greatest utility as a potential marker for DNA-based identification because of its high interspecific variability and high degree of amplification success. rbcL and trnH-psbA were successfully used in combination with morphological characters to identify a previously unidentified Moorean filmy fern species, Polyphlebium borbonlcum. The presented results support trnH-psbA as appropriate for completing the plant section of the Moorea Biocode, although the use of additional markers will be necessary.
Customized CAD Modeling and Design of Production Process for One-Person One-Clothing Mass Production System

Following the development of the Industrial Revolution 4.0, many new types of systems are being designed, introduced, or attempted, even in almost every traditional industry. The clothing industry is no exception. The use of continuously developing production equipment and Information and Communication Technology (ICT) has a single objective, providing a customized service to all customers. Thus, in this study, the primary research task was to identify ill-balanced aspects or disadvantages of the services previously analyzed to construct a more complete online customized service. This was accomplished by analyzing an automated Computer-Aided Design (CAD) output file containing customer requirements regarding individual clothing items. The secondary research task was to plan and design a clothing manufacturing process to which a one-person one-item mass production system has been applied to achieve a customized service. As a result, for the primary research task, the customers’ requirements for each dress were reflected in attributes, such as color, pattern, or size, and it was possible to obtain an automated CAD output file for each element. Such CAD output files can be used in the production process directly. To find the possibility of upgrading the existing dressmaking process and implement the one-person one-item system, the entire manufacturing process was simulated for the test.
ELECTROPHYSICAL PROPERTIES OF ZINC OXIDE THIN FILMS OBTAINED BY CHEMICAL METHODS

The electrophysical characteristics comparative studies were carried out for ZnO films obtained by chemical precipitation from zinc acetate solutions and thermal oxidation of zinc films. The ZnO films showed optical absorption and band gap (2.9 to 3.2 eV) specific for this material, which indicates the presence of crystalline structure in them. The use of polyvinyl alcohol made it possible to obtain samples with the highest values of E g and electrical resistance, which is caused by the nanosize crystallites of the films. The investigated electrophysical characteristics of the ZnO films made it possible to establish the contribution of their own defects and surface states to the conductivity.
Revisiting ignited–quenched transition and the non-Newtonian rheology of a sheared dilute gas–solid suspension

The hydrodynamics and rheology of a sheared dilute gas–solid suspension, consisting of inelastic hard spheres suspended in a gas, are analysed using an anisotropic Maxwellian as the single particle distribution function. For the simple shear flow, the closed-form solutions for granular temperature and three invariants of the second-moment tensor are obtained as functions of the Stokes number ( $St$ ), the mean density ( $\unicode[STIX]{x1D708}$ ) and the restitution coefficient ( $e$ ). Multiple states of high and low temperatures are found when the Stokes number is small, thus recovering the ‘ignited’ and ‘quenched’ states, respectively, of Tsao & Koch (J. Fluid Mech., vol. 296, 1995, pp. 211–246). The phase diagram is constructed in the three-dimensional ( $\unicode[STIX]{x1D708},St,e$ )-space that delineates the regions of ignited and quenched states and their coexistence. The particle-phase shear viscosity and the normal-stress differences are analysed, along with related scaling relations on the quenched and ignited states. At any $e$ , the shear viscosity undergoes a discontinuous jump with increasing shear rate at the ‘quenched–ignited’ transition. The first ( ${\mathcal{N}}_{1}$ ) and second ( ${\mathcal{N}}_{2}$ ) normal-stress differences also undergo similar first-order transitions: (i) ${\mathcal{N}}_{1}$ jumps from large to small positive values and (ii) ${\mathcal{N}}_{2}$ from positive to negative values with increasing $St$ , with the sign change of ${\mathcal{N}}_{2}$ identified with the system making a transition from the quenched to ignited states. The superior prediction of the present theory over the standard Grad’s method and the Burnett-order Chapman–Enskog solution is demonstrated via comparisons of transport coefficients with simulation data for a range of Stokes number and restitution coefficient.
Effect of troglitazone on plasma lipid metabolism and lipoprotein lipase

To clarify how troglitazone, an insulin-sensitizing agent, affects lipid metabolism and post-heparin plasma lipoprotein lipase(LPL), fifteen patients ( 3 male, 12 female) [ the average age 62±7 y; the mean body mass index ( BMI) 25 ± 3 kg/m2] were recruited and the serum lipids and postheparin plasma lipoprotein lipase(LPL) mass before and 4 weeks after oral administration of troglitazone ( 200 mg per day ) were measured. Mouse preadipocyte cell line, 3T3-L1 cells were treated with this compound and LPL enzyme protein mass in the culture media was measured by an enzyme linked immunosorbent assay. A reverse transcription polymerase chain reaction (RT-PCR) and Northern blot analysis was conducted to investigate the effect of this compound on the expression of LPL.The average levels before treatment of fasting serum total cholesterol, triglycerides and high density lipoprotein-cholesterol, plasma glucose and glycohemoglobin Alc were 216 ± 34, 160±84, 57± 19, 145±30 mg/dl and 7.8 ± 1.6 %. Four weeks after treatment, those levels were 209 ±36, 105 ±27 ( p=0.004 ), 63 ± 19 ( p=0.02 ) mmol/l, 139±41 mg/dl and 7.3 ±0.6 % ( p=0.01), respectively. The postheparin plasma LPL mass increased from 226 ± 39 to 257 ± 68 ng/ml( p = 0.03 ) during that period. RT-PCR and Northern blot analysis revealed that in the cultured 3T3-L1 cells, the expression of LPL was enhanced in the presence of troglitazone. These results suggests that troglitazone improves plasma triglyceride-rich lipoproteins metabolism by enhancing the expression of LPL in adipocytes.
Swift/XRT observations of unidentified INTEGRAL/IBIS sources

The most recent IBIS/ISGRI survey, i.e. the fourth one, lists 723 hard X-ray sources, many still unidentified, i.e. lacking an X-ray counterpart or simply not studied at lower energies, i.e. below 10 keV. In order to overcome this lack of X-ray information, we cross-correlated the list of IBIS sources included in the fourth IBIS catalogue with the Swift/X-ray Telescope (XRT) data archive, finding a sample of 20 objects, not yet reported in the literature, for which XRT data could help in the search for the X-ray and hence optical counterpart and/or, for the first time, in the study of the source spectral and variability properties below 10 keV. 16 of these objects are new INTEGRAL detections, while four were already listed in the third survey but not yet observed in X-rays. Four objects (IGR J00465-4005, LEDA 96373, IGR J1248.2-5828 and IGR J13107-5626) are confirmed or likely absorbed active galaxies, while two (IGR J14080-3023 and 1RXS J213944.3+595016) are unabsorbed active galactic nuclei (AGN). We also find three peculiar extragalactic objects, NGC 4728 being a narrow-line Seyfert galaxy, MCG+04-26―006 a type 2 Low Ionization Nuclear Emission Region and PKS 1143-693 probably a quasi-stellar object; furthermore, our results indicate that IGR J08262+4051 and IGR J22234-4116 are candidate AGN, which require further optical spectroscopic follow-up observations to be fully classified. Only in the case of 1RXS J080114.6―462324, we are confident that the source is a Galactic object. For IGR J10447-6027, IGR J12123―5802 and IGR J20569+4940, we pinpoint one X-ray counterpart, although its nature could not be assessed despite spectral and sometimes variability information being obtained. Clearly, we need to perform optical follow-up observations in order to firmly assess their nature. There are five objects for which we find no obvious X-ray counterpart (IGR J07506-1547 and IGR J17008―6425) or even no detection (IGR J17331-2406, IGR J18134-1636 and IGR J18175―1530); apart from IGR J18134-1636, all these sources are found to be variable in the IBIS energy band, therefore it is difficult to catch them even in X-rays.
DEVELOPMENT AND EVALUATION OF A POLOXAMER- AND CHITOSAN-BASED IN SITU GEL-FORMING INJECTABLE DEPOT

Objective: The present study is intended to investigate the applicability of poloxamer- and chitosan-based temperature induced in situ injectable gelling depot for once a week therapy as an intramuscular injection employing olanzapine as a model drug. Methods: The thermosetting gel was prepared by admixture of a solution of poloxamer P127 and a solution of olanzapine and chitosan in aqueous acetic acid. The resultant formulation was characterized for gelation temperature, gelation time, viscosity, syringeability, pH, drug content, and in vitro drug release. The in vitro release of olanzapine from the gelled depot was followed using USP paddle type II apparatus in conjunction with a dialysis bag. The gel was injected ex vivo into chicken muscle and observed by subsequent dissection. Results: The formulation was designed to have a phase transition temperature of 34°C and gelled in <10 s at 37°C. Addition of chitosan imparted favorable rheological properties to the poloxamer gel and resulted in a pseudoplastic mixture with low viscosity in the sol state and higher viscosity post gelation. The preparation had a pH of 5.4, appropriate drug content and readily passed through a 20 gauge needle. The release of olanzapine was unhindered by the dialysis bag. Following an initial bust, a sustained, zero-order release of the remainder of drug was observed up to 9 days. The injectable was found to form a compact depot when evaluated ex vivo. Conclusion: The developed system showed several features which make it a suitable vehicle for sustained intramuscular delivery of drugs.
DIGITAL TOOL FOR BLENDED LEARNING FOR TEACHING VISUAL EFFECTS

The use of digital and blended digital learning modes is becoming more popular in teaching practice at various levels of instruction. This article reports a case study with a strong experimental approach in which a digital learning object (DLO) was developed to assist in the pedagogical practice in higher education (in the audiovisual area). The objective of the research was mainly to evaluate the pedagogical contribution of DLO, however, this article is restricted to demonstrate what were the methodological paths taken during the research process for the development and conception of the tool (DLO), using theoretical references from the design area, pedagogy (regarding the construction and validation of digital learning objects), and the methodologies defined for their subsequent evaluation and validation. This article intends to contribute mainly by pointing out the design strategies adopted for the conception and creation of a Digital Learning Object for Blended Learning. Future works will present the subsequent validation results, pointing out the paths taken and new research paths to be followed to complement and further contribute to research regarding the importance of DLOs in the teaching practice of higher education. Besides, it is believed that the more research and experimentation with the construction of new DLOs and the sharing of the methods used, the better for the development, reflection and definition of better design strategies to more effectively reach the objectives initially proposed for the digital learning tool.