Miracle-dz/UniFAR-FTUs huggingface dataset:
Misleading results with the 14-3-3 assay for the diagnosis of Creutzfeldt–Jakob disease

Article abstract The definitive diagnosis of Creutzfeldt–Jakob disease (CJD) requires brain tissue analysis. A positive assay for the 14-3-3 protein in CSF has been suggested to be highly sensitive and specific in patients with CJD. The authors describe three patients for whom CSF 14-3-3 assays were falsely positive or falsely negative. Caution against overreliance on this putative biomarker is suggested in the diagnosis of CJD.
The Importance of Enrichments in the Cultivation of Bacterial Spores Previously Exposed to Lethal Agencies

Although the elemental food requirements of all microorganisms may be considered identical, the form in which the essential elements can be utilized bylthe various species is subject to almost infinite variation. Literally hundreds of different culture media have been proposed, many of which find application because they favor or prevent the growth of particular species or related groups. That the individual organisms which make up a pure culture may also vary widely in their metabolic requirements is apparently not recognized by many bacteriologists. The published reports of many investigators dealing with bacterial resistance and the cultural methods employed by a large number of our control laboratories show how little this fundamental fact affecting the nutrition of bacteria is understood. It is the purpose of the present paper to show that bacterial spores which survive destructive physical or chemical influences are much more exacting in their nutritional requirements than spores not subjected to such treatment. Evidence is presented which indicates that this phenomenon is not restricted to spores but applies to vegetative forms as well.
Bridge over troubled waters: safe and effective transitions of the inpatient with hyperglycemia.

4 Department of Medicine, Division of General Internal Medicine, Hospitalist Program, University of California, Irvine, Irvine, California. P rofessional and patient safety organizations have recognized the importance of safe transitions as patients move through the health care system, and such attention is even more critical when attempting to achieve glycemic control. Since the publication of the Diabetes Control and Complications Trial (DCCT) and the United Kingdom Prospective Diabetes Study (UKPDS), we have known that intensive glycemic control in the ambulatory setting prevents complications in both type 1 and type 2 diabetes mellitus (DM). Despite the increased risk of hypoglycemia, these trials changed practice patterns in the outpatient settings in favor of intensification of diabetes therapy. In the same way, randomized, prospective trials using intravenous (IV) insulin therapy have revolutionized our thinking about inpatient care by showing that tight glycemic control in the critically ill and patients with acute myocardial infarction reduces mortality and morbidity. These, as well as additional observational studies associating hyperglycemia with poor outcomes in a variety of medical and surgical patients, have led to increased attention on glycemic control in all venues of care. Concerns over excessive hypoglycemia and a nonsignificant increase in mortality in certain populations of medical intensive care unit (ICU) patients have raised questions over whether the initial studies can be reproduced or generalized to other groups of inpatients. Additional studies are underway to clarify these questions but consensus exists that blood glucose values should at least be less than 180 mg/dL and that the traditional practice of ignoring hyperglycemia is no longer acceptable. While a uniform focus on glycemic control will allow our patients to receive a consistent message about diabetes, the unique limitations inherent to each practice setting requires different therapeutic regimens and intentional focus on the risks as patients transition from one care area to another. This work addresses several areas of care transition that are particularly important in safely achieving glycemic control including: transition into the hospital for patients on a variety of home regimens, transitions within the hospital (related to changes in dietary intake, change from IV to subcutaneous [SC] therapy, and the perioperative setting), and the transition from the hospital to home or another healthcare facility.
Antenatal and intrapartum risk factors for perinatal asphyxia: A case controlstudy.

We have studied risk factors for perinatal asphyxia among babies fulfilling the inclusion criteria and compared them with matched controls. Maternal or antepartum factors included were maternal age, gestational age, hypertension, diabetes mellitus and antenatal clinic (ANC) visits less than 3. Intrapartum factors included malpresentation, mode of delivery, meconium stained amniotic fluid, Chorioamnionitis and Prolonged rupture of membranes. Factors independently associated with perinatal asphyxia using multiple logistic regression analysis were instrumental delivery, inadequate antenatal care, maternal anemia and meconium stained amniotic fluid. Identifying the risk factors and taking appropriate measure could help in reducing the incidence of perinatal asphyxia.
Aims and Scope

The Journal of Educational and Management Studies (ISSN: ‪2322-4770) is a peer-reviewed o pen access journal, publishes the fulltext of original researches, reviews, case reports and short communications, quarterly. JEMS is focused on learning, knowledge, skills, values, beliefs and habits as education's aims and also management goals such as planning, organizing, staffing, leading/directing and controlling. The journal aims to improve the efforts of people to accomplish goals and objectives by using available resources, efficiently and effectively.
Hybrid System Modeling and Analysis for Power Grid Side Converter Modulated by SVPWM Technology of the Double-fed Induction Wind Power Generator

A hybrid system model is given for the power grid side converter based on hybrid system theory. This converter is part of the excitation source of the double-fed induction wind power generator. With space vector pulse width modulation method, we take the modulation of a space voltage vector in the third sector as a typical example; analyze the modulation process of the approximation of the three shared zero vector method through hybrid automata theory; device the state equations of continuous-time systems, staying condition set, discrete state transition set and transition guards. A new analysis approach of the three-phase power electronic circuits through hybrid system theory has been presented.
Understanding the Role of Decision Support Systems in Green is Research: literature Review and Research Agenda

Green information systems (IS) can contribute to more sustainable actions in a globalized and complex business environment. Since sustainable actions can only result from a pluralistic decision-making process, researchers agree that decision support systems (DSSs) in particular are important for green IS research. Because this research field has grown during the last decade, we set out to identify the contribution of DSS research conducted in green IS research. We conducted a structured literature review to reveal currently available DSSs contributions, their structure, and impact. The applied literature search and selection process identified 23 papers to be relevant to the review. A conceptcentric literature analysis revealed that many DSS contributions conduct design research and demonstrate the addressed research problems’ feasibility by implemented DSS prototypes. However, the literature review identifies a lack of subscription to green IS research. Despite numerous “green” DSSs are available in the literature, their subscription to the field of green IS research is missing. Finally, a research agenda is conceptualized for systematizing future DSS research in the domain of green IS research. Further research should increase the number of contributions conducting designoriented research that should mainly result in software implementations to demonstrate the solutions’ feasibility and “green” utility.
Transarterial Endoleak Closure After Endovascular Thoracoabdominal Aneurysm Repair

Purpose: To describe the use of vascular plugs to close a complex type Ib endoleak following the sandwich procedure used in conjunction with endovascular thoracoabdominal aortic aneurysm (TAAA) repair. Case Report: A 59-year-old man with a 6.5-mm TAAA was treated with initial deployment proximally of 2 Zenith TX2 stent-grafts. In preparation for the sandwich technique to preserve flow to the celiac trunk, a 10×100-mm Viabahn covered stent was delivered from a brachial access into the celiac trunk unprotected by the sheath of the introducer. The trigger wire system became snagged on the struts of the distal aortic stent-graft; when the wire was pulled, the proximal end of the Viabahn migrated outside the aortic stent-graft, which migrated upward. The main body extension intended for the aortic component of the sandwich technique was deployed close to the distal end of the aneurysm sac, but a large type Ib endoleak formed in the gutter between the Viabahn, aortic extension, and sac wall. The leak perfused the celiac trunk, and the procedure was terminated. Increasing sac size on 3-month imaging prompted closure of the leak with 2 type II Amplatzer vascular plugs aiming to occlude the endoleak outflow into the Viabahn and the endoleak outflow at the site of the gutter. Imaging follow-up at 6 months demonstrated successful exclusion of the TAAA with no residual endoleak and excellent perfusion of the celiac trunk. Conclusion: Transarterial treatment of complex endoleaks is feasible when preceded by meticulous imaging and detailed preprocedural planning.
Radiation sensitivity of Cajanus cajan to gamma radiations.

Gamma irradiation induces various physiological, biochemical alterations in plants with modulation of certain metabolic and defensive pathway. Pre-sowing seed irradiation is considered as an effective method of improving production, yield components and chemical composition in plants. In the present study Cajanus Cajan was subjected to gamma irradiation with absorbed doses 0 Gy, 30 Gy, 50 Gy, 100 Gy, 150 Gy and 200 Gy with a dose rate 2.08 Kilo Gray per hour (2.08 KGh-1). Cajanus cajan when exposed to variable doses of gamma radiation showed persistent changes in the growth and development under both in vivo & in vitro conditions. Radiation sensitivity test based on germination percentage of irradiated and non-irradiated seeds demonstrated that significant reduction in germination percentage was observed with increasing gamma dosage under both in vivo and in vitro conditions. Biochemical analysis confirmed that protein, photosynthetic pigments, proline are very sensitive to gamma radiation, and are good indicators of tolerance. Effective stimulatory dose for plant development under in vivo conditions is 100 Gy while the absorbed doses of 150 Gy and 200 Gy can prove detrimental. However under in vitro conditions, results hold 150 Gy as threshold dose for increasing plant growth, plant vigour and development. Conclusively productivity of Cajanus cajan and consequent economic gains could be enhanced through adoption of suitable cultivar and level of gamma radiation. Gamma rays prove to be an important tool in increasing the breeding efficiency and regeneration frequency, especially that of the recalcitrant varieties. Results in the present study provide sufficient evidence to the effect that γ-irradiation does activate a biochemical system.
Automatic Isosurface Propagation Using an Extrema Graph and Sorted Boundary Cell Lists

A high-performance algorithm for generating isosurfaces is presented. In our method, guides to searching for cells intersected by an isosurface are generated as a pre-process. These guides are two kinds of cell lists: an extrema graph, and sorted lists of boundary cells. In an extrema graph, extremum points are connected by arcs, and each arc has a list of cells through which it passes. At the same time, all boundary cells are sorted according to their minimum and maximum values, and two sorted lists are then generated. Isosurfaces are generated by visiting adjacent intersected cells in order. Here, the starting cells for this process are found by searching in an extrema graph and in sorted boundary cell lists. In this process, isosurfaces appear to propagate themselves. Our algorithm is efficient, since it visits only cells that are intersected by an isosurface and cells whose IDs are included in the guides. It is especially efficient when many isosurfaces are interactively generated in a huge volume. Some benchmark tests described in this paper show the efficiency of the algorithm.
Rho GTPases in platelet function

Summary. The Rho family of GTP binding proteins, also commonly referred to as the Rho GTPases, are master regulators of the platelet cytoskeleton and platelet function. These low‐molecular‐weight or ‘small’ GTPases act as signaling switches in the spatial and temporal transduction, and amplification of signals from platelet cell surface receptors to the intracellular signaling pathways that drive platelet function. The Rho GTPase family members RhoA, Cdc42 and Rac1 have emerged as key regulators in the dynamics of the actin cytoskeleton in platelets and play key roles in platelet aggregation, secretion, spreading and thrombus formation. Rho GTPase regulators, including GEFs and GAPs and downstream effectors, such as the WASPs, formins and PAKs, may also regulate platelet activation and function. In this review, we provide an overview of Rho GTPase signaling in platelet physiology. Previous studies of Rho GTPases and platelets have had a shared history, as platelets have served as an ideal, non‐transformed cellular model to characterize Rho function. Likewise, recent studies of the cell biology of Rho GTPase family members have helped to build an understanding of the molecular regulation of platelet function and will continue to do so through the further characterization of Rho GTPases as well as Rho GAPs, GEFs, RhoGDIs and Rho effectors in actin reorganization and other Rho‐driven cellular processes.
Optimizing virtual machines scheduling on high performance network NUMA systems

Non-Uniform Memory Access (NUMA) architecture is being widely used in virtualization and cloud computing due to its scalability. In NUMA system, previous works mainly focused on how affinity between processor and memory could be optimized by scheduling. However, we observed that in NUMA system with high-performance virtualized network enable, the network affinity is also an important factor affecting the performance of VM. In this paper, we analyze the affinities among processor, memory and NIC in depth. Based on the analysis, we designed and implemented a VM scheduler, named as vNAASched, in KVM. vNAASched monitors and collects performance events of VMs at runtime and schedules VMs based on the affinities among processor, memory and NIC. Experiment results showed that vNAASched is able to improve performance of real-world Apache Spark workloads by up to 36%.
A new fusion algorithm for fuzzy clustering

In this paper we have considered the merging problem of two ellipsoidal clusters in order to construct a new fusion algorithm for fuzzy clustering.We have proposed a criterion for merging two ellipsoidal clusters $\pi_1,\pi_2$ with associated main Mahalanobis circles $E_j(c_j,\sigma_j)$, where $c_j$ is the centroid and $\sigma^2_j$ is the Mahalanobis variance of cluster $\pi_j$. Based on the well-known Davies-Bouldin index we have constructed a new fusion algorithm. The criterion has been tested on several data sets, and the performance of the fusion algorithm has been demonstrated on an illustrative example.
Semianalytic Solution for a Simple Model of Inrush Currents in Transformers

This paper presents a proposal of a semianalytic solution for the system of differential equations that governs the behavior of a power transformer under energization. The presented model takes into account nonlinearity due to magnetization curve. The proposed approach for the solution uses recursive expressions, applied to the description of the transformer inrush current. The inrush current in a 120-VA small transformer is simulated and the results of the proposed method agree with the values obtained experimentally.
A factorial study of physical constitution in women.

1. The paper describes a factorial analysis of the intercorrelations of 15 anthropometric variables in a group of 200 service women neurosis patients successively admitted to Mill Hill Emergency Hospital. 2. The criteria used in the past for classifying body build are described, and the need for an inductive approach emphasized. The difficulties encountered in classifying female body build are discussed, and anthropometric sex differences considered in the light of a comparison of male and female groups and sex growth differentials. 3. The matrix of tetrachoric correlations of the 15 anthropometric variables was analysed by Burt's summation method and two main factors were extracted: 1. General factor influencing growth in all directions and accounting for 41 per cent. of the variance. 2. Type factor which was bipolar, having positive saturation with length measurements and negative saturation with breadth, width and circumferential dimensions. This factor accounted for 16 per cent. of the variance, and is the factor responsible for the existence of two antithetical types of body build, the narrow or leptomorph and the broad or eurymorph type. 4. The relationship of the factors to growth processes is considered in relationship to physical development of children at various ages, types of growth in animal kingdom and genetic aspects. 5. The prerequisites of a body-build index are described. Utilizing the results of factor analysis, the following measurements were selected for inclusion in a body build index because of their high saturation with the type factor: Stature, symphysis height, chest and hip circumference. A regression equation containing the four measurements duly weighted according to saturation with the type factor was calculated as follows: Index of female body build = + . 59 stature + . 47 symphysis height −. 31 chest circumference −. 64 hip circumference. 6. The new index of female body build was calculated in a group of 400 women service neurosis patients. The frequency distribution curve of the index was normal and unimodal, indicating a continuous variation in physique, therefore lending no support to the theory of the existence of discrete physical types. 7. Using demarcation points at one standard deviation below the mean the frequency distribution curve was divided into— 1. Leptomorphs with index value + 5.0 and higher. 2. Mesomorphs −2.59 to + . 5.0. 3. Eurymorphs −2.59 and less. These ranges of physique, being capable of objective delineation by the new index of body build, afford convenient body-type classes for clinical practice and research.
On Model Based Regression Testing of Web Services

Regression testing is helpful in finding out if the quality of an evolved system has not regressed during maintenance. In case of web services, it becomes an issue since access to implementation is restricted to interface level information only. The problems gets further complicated if the testing is manual and the effect of maintenance is minimal. We can establish an idea about the depth of changes through the analysis of exposed interface and provide test oracle by storing test data and returned values in case of successful test cases. This paper proposes an interface analysis approach where we analyze these interfaces written in web service description language (WSDL). We utilize data collected form interface analysis to invoke service operations and develop test oracles. We use these test oracles for regression testing to ensure there is no regression in the operations where the interface has not changed. In case, the interface has changed, we can detect by rerunning interface analysis to find out evolution in the signature.
Disposition of moxalactam and N-methyltetrazolethiol in rats and monkeys

The disposition of moxalactam (MOX) and N-methyltetrazolethiol (NMTT) in rats and monkeys after intravenous injection was investigated, focusing on the in vivo liberation of NMTT, by using [NMTT-14C]MOX and [14C]NMTT. After [NMTT-14C]MOX injection, MOX levels in plasma quickly became high in both rats and monkeys and then declined, with half-lives at the beta phase of 18.8 and 67.1 min, respectively. The levels of NMTT liberated from MOX were much lower than those of MOX, but the apparent elimination was significantly slow. The levels of MOX and NMTT in rat liver were almost comparable but lower than those in plasma. With [14C]NMTT administration, the level of NMTT in plasma declined, with half-lives at the beta phase of 21.5 min in rats and 54.0 min in monkeys. After [NMTT-14C]MOX injection, most of the radioactivity was excreted in urine as MOX, with 11% of the dose in rats and 8% of the dose in monkeys eliminated as NMTT until 24 h. Total biliary excretion was 26% of the injected radioactivity in rats, and most of it was due to MOX. In one monkey, the total biliary excretion was only 0.2% of the injected radioactivity. With [14C]NMTT administration, most radioactivity was excreted in the urine as unchanged NMTT in both animals. Oral administration in rats showed that part of the biliary-excreted MOX was degraded to NMTT in the intestine and then absorbed. Repeated administration of [NMTT-14C]MOX to rats did not change the levels of MOX and NMTT in plasma or liver nor did it change the excretion profiles. Thus, accumulation of MOX and NMTT did not occur.