Miracle-dz/UniFAR-FTUs huggingface dataset:
Validity of the self-reported number of natural teeth in Japanese adults.

AIM The aims of this research were to assess the validity of self-reporting of the number of teeth by comparing the number with that obtained through clinical dental examinations, and to investigate factors affecting the discordance between the two measures. METHODS Self-administered questionnaires and dental examinations were conducted among 1152 dentate community residents in Japan. The validity of the patients' reports of the number of teeth was assessed by comparing the self-reported number with that determined at the clinical examination. Factors affecting the absolute value of the difference between the self-reported number of teeth and the number at clinical examination were investigated using a multivariate analysis. RESULTS Overall, 47.5% of participants had perfect agreement in their self-report with the clinical examination. There was a slight tendency toward underestimation of the number of natural teeth by self-reporting. Pearson's correlation coefficient was 0.80, and the intraclass correlation coefficient was 0.78 for all patients. Decayed, filled, sound teeth, and fixed prosthetic pontics were significantly associated with the absolute value of the difference between self-reports and clinical examinations. CONCLUSIONS Patients' reported number of remaining teeth, the data for which were collected via the questionnaire, provided reasonably valid data on the actual number of teeth within a population group.
Differential item functioning of the Spanish version of the Child Perceptions Questionnaire.

AIM Owing to the greater use of translated and adapted instruments for measuring oral health on children's quality of life, there is a need to ensure that such scales (and then items) function in the same way, irrespective of age, sex, socioeconomic status, language, or ethnicity, so they can be used validly and reliably in cross-cultural research. The aim of the present study was to identify whether the Spanish version of the Child Perceptions Questionnaire 11-14 presents differential item functioning. METHODS Child Perceptions Questionnaire 11-14 data from New Zealand (n = 322) and Mexican (n = 335) school-based surveys were compared. Ordinal logistic regression was undertaken in order to identify uniform or non-uniform differential item functioning. RESULTS Eleven items showed moderate-to-large uniform differential item functioning in the Spanish version of the Child Perceptions Questionnaire 11-14. Non-uniform differential item functioning was not detected. The psychometric properties of the questionnaire, when removing items showing differential item functioning, showed that the free differential item functioning version was good to excellent. CONCLUSIONS The Child Perceptions Questionnaire 11-14 Spanish version showed moderate-to-large uniform differential item functioning; however, further research is needed to identify the causes of differential item functioning.
Outbreak of Escherichia coli Infections Associated with a Contaminated Transesophageal Echocardiography Probe

Infection Control & Hospital Epidemiology / Volume 34 / Issue 10 / October 2013, pp 1121 1123 DOI: 10.1086/673160, Published online: 02 January 2015 Link to this article: http://journals.cambridge. org/abstract_S019594170003407X How to cite this article: Elizabeth A. Bancroft, L'Tanya English, Dawn Terashita and Lori Yasuda (2013). Outbreak of Escherichia coli Infections Associated with a Contaminated Transesophageal Echocardiography Probe. Infection Control & Hospital Epidemiology, 34, pp 1121-1123 doi:10.1086/673160 Request Permissions : Click here
Sex-Chromosome Turnovers: The Hot-Potato Model

Sex-determining systems often undergo high rates of turnover but for reasons that remain largely obscure. Two recent evolutionary models assign key roles, respectively, to sex-antagonistic (SA) mutations occurring on autosomes and to deleterious mutations accumulating on sex chromosomes. These two models capture essential but distinct key features of sex-chromosome evolution; accordingly, they make different predictions and present distinct limitations. Here we show that a combination of features from the two models has the potential to generate endless cycles of sex-chromosome transitions: SA alleles accruing on a chromosome after it has been co-opted for sex induce an arrest of recombination; the ensuing accumulation of deleterious mutations will soon make a new transition ineluctable. The dynamics generated by these interactions share several important features with empirical data, namely, (i) that patterns of heterogamety tend to be conserved during transitions and (ii) that autosomes are not recruited randomly, with some chromosome pairs more likely than others to be co-opted for sex.
Diagnosis of ventilator-associated pneumonia: is there a gold standard and a simple approach?

Purpose of reviewDiagnosis of ventilator-associated pneumonia remains controversial. Different approaches are advocated, but none has yet demonstrated superiority. Diagnosis based on clinical data and aetiological diagnosis of ventilator-associated pneumonia episodes are two concepts that should be combined in an integrative evaluation for ventilator-associated pneumonia. Recent findings in diagnosis are reviewed here. Recent findingsStudies of various diagnostic strategies have been conducted to evaluate whether they influence outcome. Strategies include use of biomarkers (e.g. C-reactive protein and procalcitonin) and use of clinical scores to render the diagnostic process more objective. The appropriateness of the available aetiological diagnostic techniques and their reliability in the absence of a ‘gold standard’ for diagnosis were also recently addressed. It remains controversial whether type of culture (quantitative or nonquantitative) or sampling method (invasive or noninvasive) influences aetiological diagnosis or outcomes in ventilator-associated pneumonia. It is unlikely that any single approach is the optimal diagnostic assessment whenever ventilator-associated pneumonia is suspected. SummaryMicrobiological data should always be used in association with clinical data when assessing patients with suspected ventilator-associated pneumonia. Integration of these data might be the most simple and effective strategy for diagnosing ventilator-associated pneumonia.
Coagulation and the Vessel Wall in Pulmonary Embolism

Venous thromboembolism comprises deep-vein thrombosis, thrombus in transit, acute pulmonary embolism, and chronic thromboembolic pulmonary hypertension (CTEPH). Pulmonary thromboemboli commonly resolve, with restoration of normal pulmonary hemodynamics. When they fail to resorb, permanent occlusion of the deep veins and/or CTEPH are the consequences. Apart from endogenous fibrinolysis, venous thrombi resolve by a process of mechanical fragmentation, through organization of the thromboembolus by invasion of endothelial cells, leukocytes, and fibroblasts leading to recanalization. Recent data utilizing various models have contributed to a better understanding of venous thrombosis and the resolution process that is directed at maintaining vascular patency. This review summarizes the plasmatic and cellular components of venous thrombus formation and resolution.
A Comprehensive Review: The Evolution of Animal Models in Pulmonary Hypertension Research; Are We there Yet?

Pulmonary hypertension (PH) is a disorder that develops as a result of remodeling of the pulmonary vasculature and is characterized by narrowing/obliteration of small pulmonary arteries, leading to increased mean pulmonary artery pressure and pulmonary vascular resistance. Subsequently, PH increases the right ventricular afterload, which leads to right ventricular hypertrophy and eventually right ventricular failure. The pathophysiology of PH is not fully elucidated, and current treatments have only a modest impact on patient survival and quality of life. Thus, there is an urgent need for improved treatments or a cure. The use of animal models has contributed extensively to the current understanding of PH pathophysiology and the investigation of experimental treatments. However, PH in current animal models may not fully represent current clinical observations. For example, PH in animal models appears to be curable with many therapeutic interventions, and the severity of PH in animal models is also believed to correlate poorly with that observed in humans. In this review, we discuss a variety of animal models in PH research, some of their contributions to the field, their shortcomings, and how these have been addressed. We highlight the fact that the constant development and evolution of animal models will help us to more closely model the severity and heterogeneity of PH observed in humans.
Synergism of Natural Selection and Introgression in the Origin of a New Species*

This article explores how introgressive hybridization enhances the evolutionary effects of natural selection and how, reciprocally, natural selection can enhance the evolutionary effects of introgression. Both types of interaction were observed during a 40-year study of Darwin’s finches (Geospiza) on the small Galápagos island of Daphne Major. Hybrids, produced rarely by Geospiza fortis (medium ground finch) breeding with Geospiza scandens (cactus finch) and Geospiza fuliginosa (small ground finch), survived and bred as well as the parental species in the past 3 decades. By backcrossing, they increased the standing genetic variation and thereby the evolutionary responsiveness of the populations to natural selection. Natural selection occurred in droughts and oscillated in direction as a result of climatically induced fluctuations in food composition. Introgressive hybridization has led to the formation of a new lineage. It was initiated by a large, introgressed, hybrid male with a unique song and genetic marker that immigrated from the nearby island of Santa Cruz and bred with local hybrids and with G. fortis. All members of the lineage died in the 2003–2005 drought except a brother and a sister, who then bred with each other. Subsequent increase in the lineage was facilitated by selective mortality of the largest G. fortis. Breeding endogamously, the lineage is behaving as a biological species.
Are we any closer to beating the biofilm: novel methods of biofilm control

Purpose of review A multidisciplinary approach to the treatment and management of biofilms has resulted from the growing appreciation of the role that biofilms play in modern medicine. Conventional antimicrobial agents are generally ineffective against biofilms, and as a result novel laboratory-based and clinical strategies have emerged. The purpose of this review is to analyse the recent literature relating to novel treatment strategies targeting the growing spectrum of clinically relevant biofilms. Recent findings Microscopy and molecular techniques have provided greater insights into identifying the key bacterial and fungal biofilm pathogens. Knowledge of these microorganisms has provided a foundation for the development of specific molecules, often microbial derived, with antimicrobial and/or biofilm disruptive properties, augmenting conventional antibiotics treatments. The validity of some such rationally designed therapeutics has been explored in clinical trials. Summary Biofilms are inherently difficult to treat, and mechanical disruption is the mainstay of clinical management. With scientific progress in molecular microbiology, there is an abundance of newly discovered molecules and pathways, providing novel therapeutic and prophylactic targets.
Adaptations between Ecotypes and along Environmental Gradients in Panicum virgatum*

Determining the patterns and mechanisms of natural selection in the wild is of fundamental importance to understanding the differentiation of populations and the evolution of new species. However, it is often unknown the extent to which adaptive genetic variation is distributed among ecotypes between distinct habitats versus along large-scale geographic environmental gradients, such as those that track latitude. Classic studies of selection in the wild in switchgrass, Panicum virgatum, tested for adaptation at both of these levels of natural variation. Here we review what these field experiments and modern agronomic field trials have taught us about natural variation and selection at both the ecotype and environmental gradient levels in P. virgatum. With recent genome sequencing efforts in P. virgatum, it is poised to become an excellent system for understanding the adaptation of grassland species across the eastern half of North America. The identification of genetic loci involved in different types of adaptations will help to understand the evolutionary mechanisms of diversification within P. virgatum and provide useful information for the breeding of high-yielding cultivars for different ecoregions.
Selective Endothelin-A Receptor Blockade Attenuates Endotoxin-Induced Pulmonary Hypertension and Pulmonary vascular dysfunction

Endothelin-1 is a potent mediator of sepsis-induced pulmonary hypertension (PH). The pulmonary vascular effects of selective blockade of endothelin receptor subtype A (ETAR) during endotoxemia remain unknown. We hypothesized that selective ETAR antagonism attenuates endotoxin-induced PH and improves pulmonary artery (PA) vasoreactivity. Adult male Sprague-Dawley rats (250–450 g) received lipopolysaccharide (LPS; Salmonella typhimurium; 20 mg/kg intraperitoneally) or vehicle 6 hours before hemodynamic assessment and tissue harvest. The selective ETAR antagonist sitaxsentan (10 or 20 mg/kg) or vehicle was injected intravenously 3 hours after receipt of LPS. Right ventricular systolic pressure, mean arterial pressure (MAP), cardiac output (CO), oxygenation (P/F ratio), and serum bicarbonate were measured. Bronchoalveolar lavage (BAL) cell differential and lung wet-to-dry ratios were obtained. Endothelium-dependent and endothelium-independent vasorelaxations were determined in isolated PA rings. PA interleukin (IL)-1β, IL-6, tumor necrosis factor α (TNF-α), and inducible nitric oxide synthase (iNOS) messenger RNA (mRNA) were measured. LPS caused PH, decreased MAP, CO, and serum bicarbonate, and increased PA IL-1β, IL-6, TNF-α, and iNOS mRNA. Sitaxsentan attenuated sepsis-induced PH and increased MAP. The P/F ratio, CO, serum bicarbonate, and BAL neutrophilia were not affected by sitaxsentan. In isolated PA rings, while not affecting phenylephrine-induced vasocontraction or endothelium-dependent relaxation, sitaxsentan dose-dependently attenuated LPS-induced alterations in endothelium-independent relaxation. PA cytokine mRNA levels were not significantly attenuated by ETAR blockade. We conclude that ETAR blockade attenuates endotoxin-induced alterations in systemic and PA pressures without negatively affecting oxygenation. This protective effect appears to be mediated not by attenuation of sepsis-induced cardiac dysfunction, acidosis, or alveolar inflammation but rather by improved endothelium-independent vasorelaxation.
Adverse Childhood Experiences and Subsequent Substance Abuse in a Sample of Sexual Offenders: Implications for Treatment and Prevention

Abstract The purpose of this study was to explore the prevalence of substance abuse indicators in a sample of male sexual offenders (N = 679) and to examine the influence of adverse childhood experiences (ACE) on the likelihood of substance abuse outcomes. Half of these sex offenders reported a history of drug or alcohol abuse, and nearly one in five reported a substance-related arrest. Higher ACE scores were associated with endorsement of a greater number of substance-abuse-related problems, suggesting that accumulation of early trauma may increase the likelihood for substance misuse. By enhancing our understanding of the frequency and antecedents of dynamic risk factors such as substance abuse, we can better devise clinical interventions that respond to the comprehensive needs of sexually abusive individuals and reduce risk for sexual reoffense. As well, early interventions for at-risk families and maltreated youth may interrupt their trajectory toward adulthood substance abuse and criminal behavior, including sex offending.
Reconciling Diversification: Random Pulse Models of Speciation and Extinction

Inferring the underlying speciation-extinction dynamics of a clade from the phylogenetic relationships of contemporary species has proven difficult, primarily because the record of extinction is absent. Moreover, models of diversification tend to emphasize either time homogeneity or gradual trends in speciation and extinction rates. In contrast, the fossil records of many groups exhibit repeated increase and decrease of species richness within clades. Modeling this dynamic in the structure of phylogenetic trees has had limited application. Here, I consider the idea that pulses of diversification followed by declines in clade size—such pulses having short life spans in evolutionary time—occur frequently and more or less randomly among lineages. I suggest that this model might characterize diversification quite generally. Analyses of a recent phylogeny of the ovenbirds and treecreepers (Aves: Furnariidae) supports the random pulse model in that ancestral lineages at 15, 10, and 5 Ma exhibit diversification rate heterogeneity, but the sizes of ancestral and descendant lineages are uncorrelated. Simulations of such a process and its manifestations in reconstructed phylogenies would help to characterize diversification pulses in an abstract sense and draw attention to the underlying biological processes that produce them.
Can We Make Time for Physical Activity? Simulating Effects of Daily Physical Activity on Mortality

Background. The link between physical activity and health outcomes is well established, yet levels of physical activity remain low. This study quantifies effects on mortality of the substitution of low activity episodes by higher activity alternatives using time-use data. Methods. Sample time profiles are representative of the Canadian population (). Activity time and mortality are linked using metabolic equivalents(METs). Mortality risk is determined by peak daily METs and hours spent sedentary. The impact of altering activity patterns is assessed using simulated life expectancy. Results. If all leisure screen time was replaced with an equal amount of time spent going for a walk, an increase in life expectancy of about 2.5 years (95% CI, 1.4 to 3.8) would be expected. No other activity category would have as large as an effect. Conclusions. Reducing leisure screen time has a large effect, because seniors particularly have a large potential for mortality reduction and watch more television than other age groups. The general problem of inactivity cannot be solved simply by reallocating time to more active pursuits, because daily activity patterns can be heterogeneous or fragmented and activities may be nondiscretionary (e.g., work or childcare).
RFID Continuance Usage Intention in Health Care Industry

Radio-frequency identification (RFID) has been proved to be an effective tool both for improving operational efficiency and for gaining competitive advantage in the health care industry despite its relatively low-usage rate in hospitals. The sustained use of RFID by health care professionals will promote its development in the long term. This study evaluates the acceptance continuance of RFID among health care professionals through technology continuance theory (TCT). Data were collected from 178 medical professionals in Malaysia and were then analyzed using the partial least squares technique. The analysis showed that the TCT model provided not only a thorough understanding of the continuance behavior of health care professionals toward RFID but also the attitudes, satisfaction, and perceived usefulness of professionals toward it. The results of this study are expected to assist policy makers and managers in the health care industry in implementing the RFID technology in hospitals by understanding the determinants of continuance of RFID usage intention.
Influence of the success of psychoeducational interventions on the course of family care.

A reanalysis is presented of a previously reported study in order to investigate whether the short-term success of caregiver interventions is associated with positive longer-term outcomes. This new analysis focuses on whether or not families institutionalized their relative in the year following treatment, and the influence of response to treatment on the placement decision. Treatment outcomes (i.e., whether caregivers improved, failed to improve, or dropped out of treatment) were found to predict patient placement one year following initial assessment. Thus, caregiver interventions may have longer-term positive effects related to rates of patient institutionalization.
Development of Practice Guidelines for Assessment and Management of the Vegetative and Minimally Conscious States

The Aspen Neurobehnvioml Conference was convened as a venue to consider interactions of mind and brain with regard to health and disease. The primary purpose of the conference was to provide a forum for discussion and scientific collaboration, particularly in areas marked by uncertainty and controversy, with eventual dissemination of conclusions. One of the selected topics for the inaugural session of the conference concerned the development of guidelines for evaluation and management of the vegetative and minimally conscious states. The purpose of this article is to acquaint neurorehabilitation specialists with the unique approach to consensus-based guideline development utilized at the Aspen Conference and to summarize the proceedings of the Aspen Workgroup on the Vegetative and Minimally Conscious States conducted since 1994
Environment-Dependent Sexual Selection: Bateman’s Parameters under Varying Levels of Food Availability

Sexual selection is a potent evolutionary force that has been shown to vary in strength and direction depending on demographic factors such as density and sex ratio. However, the effect of other environmental factors on the mode of sexual selection remains largely unexplored. Here, we tested experimentally how food restriction affects the potential for sexual selection in the male and the female sex function of the simultaneously hermaphroditic freshwater snail Physa acuta. We manipulated food availability and compared Bateman’s metrics of sexual selection between groups of five well-fed and five food-restricted snails. Food-restricted individuals had a reduced female reproductive output, suggesting that we successfully manipulated the reproductive resources. Importantly, food restriction reduced the male opportunity for sexual selection (in terms of a lowered variance in male mating success) and led to diminishing returns of mating in both sexes (in terms of nonsignificant Bateman gradients). Furthermore, we observed significant changes in the relative contribution of different fitness components, suggesting stronger postcopulatory selection in the male sex role and stronger fecundity selection in the female sex role under restricted food conditions. This study highlights the need to incorporate ecological factors to better understand how sexual selection operates in the wild.