Miracle-dz/UniFAR-FTUs huggingface dataset:
Fault Diagnosis of Open-Switch Failure in a Grid-Connected Three-Level Si/SiC Hybrid ANPC Inverter

A diagnostic method for an open-circuit switch failure in a hybrid active neutral-point clamped (HANPC) inverter is proposed in this paper. The switching leg of the HANPC inverter consists of four silicon insulated gate bipolar transistors and two silicon carbide metal-oxide-semiconductor field-effect transistors to achieve higher efficiency and power density compared to conventional neutral-point clamped inverters. When an open-circuit failure occurs in a switching device, the output current is severely distorted, causing damage to the inverter and the connected loads. The proposed diagnostic method aims to detect the open-switch failure and protect the related devices without additional sensors or circuits. The faulty conditions of six different switches are investigated based on the current distortion in the stationary reference frame. By analyzing the individual characteristic of each switch failure, it is possible to detect the exact location of the failed switch in a short period. The effectiveness and feasibility of the proposed fault-diagnostic method are verified using simulation and experimental results.
Effects of Fermentation Conditions on the Production of Secondary Metabolites of Penicillium brevicaule alba-CC200 and Aspergillus egypticus–HT166 Inhibiting Pancreatic α-Amylase

Microbial fermentation is a complex process and metabolic processes in microorganisms seriously depend on cultural parameters (Scherlach et al., 2009). Variations of fermentation conditions such as medium composition, aeration, temperature, or the shape of the culture vessel, can lead to changes in the metabolic profile of a strain and influence the yields of certain compounds (Yuniati et al., 2018; Amna et al., 2012). Recently, the term ‘‘OSMAC’’ (one strain many compounds) was proposed to describe the long known effects of the fermentation parameters on secondary metabolites biosynthesis by any given microorganism, from increasing in the number of produced compounds to the accumulation of hitherto unknown natural products (Grond et al., 2002; Bode et al., 2000; Rateb et al., 2011). It was shown that different cultural conditions lead to the discovery of new natural substances. This is especially true for endophytic microorganisms with their wide spectrum of interactions with the host plant International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 9 Number 2 (2020) Journal homepage: http://www.ijcmas. com
RETROSPECTIVE COMPARATIVE STUDY OF BONE LOSS IN IMPLANTS WITH AND WITHOUT IMMEDIATE LOADING IN THE EGAS MONIZ UNIVERSITY CLINIC

To evaluate bone loss after three years in implants placed at the implantology consult at the Egas Moniz University Clinic, relating bone loss to the type of loading (conventional or immediate load). A comparative and retrospective study, performed on a sample of 65 implants, placed in 24 of 327 patients, who attended the implantology consult at the Egas Moniz University Clinic in 2015, representing 7.3% of the study population through the measurement of distance between implant platform and bone using radiographs. Three years after implant placement with and without immediate loading there is statistically significant bone loss mesially and distally. It was found that when compared bone loss in loaded vs unloaded mesially and distally implants, there were no statistically significant differences. The bone loss of the unloaded implants was compared three years after being placed, with the bone level of the loaded implants also three years later. No significant difference was found. Although no statistically significant differences were found between bone loss in loaded implants vs unloaded mesially and distally, as it is supported by the literature, it was possible to conclude that there was, in fact, a statistically significant bone loss, mesially and distally, three years after implant placement with and without immediate loading. This may be due to poor oral hygiene, a history of periodontitis, smoking and peri-implantitis.
PRODUTIVIDADE DE Pleurotus ostreatus EM RESÍDUOS DA AMAZÔNIA

La viabilidad de aprovechamiento de residuos madereros y agroindustriales, disponibles en la region amazonica, para la formulacion de sustratos alternativos para el cultivo de Pleurotus ostreatus fue probada. Para eso, fueron selecionados dos residuos madereros: aserrin de marupa (SIAMP) y de balso (SAPB); y dos residuos de origen agro-industrial: bagazo de cana de azucar (SIACN) y tallo de pijiguao (SIAPP). Estos fueron suplementados con una mezcla de salvado de arroz, trigo y maiz, como fuente de proteina, con adicion de 2-3% de CaCO3 para la correccion del pH (6,5). Los sustratos fueron acondicionados en bolsas PEAD, esterilizados a 121°C por 1h e inoculados en camara de flujo laminar. El cultivo fue conducido de forma axenica, en atmosfera modificada. La productividad de los sustratos fue evaluada de acuerdo a la eficiencia biologica donde fueron alcanzados los respectivos resultados promedio en porcentajes: 125,60%, 99,80%, 94,00% y 64,60%, para SIAPP, SIACN, SIAMP y SIAPB, respectivamente. La alta eficiencia biologica de los sustratos, asi como el proceso de cultivo, evidencio la viabilidad de aprovechamiento de los residuos, sugiriendo el cultivo comercial de ese hongo, que podria contribuir para una mejoria de las condiciones socioeconomicas y sustentabilidad de los recursos de la biodiversidad regional de la Amazonia
Innate immunity against respiratory pathogens

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Defending the Queen’s Pride: Effect of the menstrual cycle phase on conspicuous consumption

Women experience both physical and psychological changes during different phases of the menstrual cycle (MC), which can affect their decision making. The present study aims to investigate the impact of the MC on women’s preferences for conspicuous consumption. In three studies, women in the low-fertility phase were found to be more inclined toward conspicuous consumption, with the MC effect on conspicuous consumption being mediated by the extent of pride. We assumed that women in the low-fertility phase would feel less proud due to an evolutionary drive and that they would consume conspicuous products as a means of compensation. Meanwhile, women who were only children did not manifest such behavior. We infer that women from one-child families may have a greater sense of security and confidence, which buffers the mediating effect. This research contributes to both evolutionary psychology and marketing research and provides new insights for future studies.
Breast Tumor Ablation by Selective Autophagic Degradation of Postmitotic Midbodies

Abstract : Breast cancer develops from epithelial lesions in breast ducts and lobules that become invasive and can be metastatic. Breast cancer is a disease of uncontrolled cell division. Cell division normally creates two genetically identical daughter cells through severing of a cytoplasmic bridge that interconnects them. The midbody is an organelle involved in severing. Previously midbodies were thought to be lost from cells after division, but we show they can be retained. Here we show that MBs exhibit stem cell properties and are in breast cancer stem cells (Task 1). They are scaffolds for anchoring breast cancer oncogenes, tumor suppressors and breast cancer stem cell proteins. Increasing MB+ cells increases in vitro tumor potential ( Task 2). We activated a MB-degradation pathway that decreased MBs and tumorigenic properties of breast cancer cells (Task 3). Because MBs are in breast cancer stem cells, we believe this MB targeting strategy may be an innovative strategy for therapies focused on the most difficult of all tumors, those thought to be caused by cancer stem cells, namely recurrent, resistant and metastatic cancers.
Biochemical and Structural Characterisation of Dehalogenases from Marine Bacteria

An L-haloacid dehalohenase from the psychrophilic marine bacteria Psychromonas ingrahamii has been cloned, over-expressed in a bacterial expression system and biochemically characterised. The enzyme is stable at temperatures of up to 60oC for 90 min and shows highest activity towards substrates with short carbon chains (≤C3). The enzyme is stable in up to 30% ethanol, methanol and DMSO when incubated for 1 h. The Km for the enzyme is 1.36 mM. The genome of AQP5750 from the Aquapharm Biodiscovery Ltd Microbial library was sequenced. An L-haloacid dehalohenase and a haloalkane dehalogenase gene were identified within the genome. The AQP5750 L-haloacid dehalohenase has been cloned, over-expressed in a bacterial expression system, biochemically characterised, crystallized and the native and crystal complex structure with chloropropionic acid (MCP) determined. The Lhaloacid dehalohenase from AQP5750 shows highest activity at 55oC towards brominated substrates with short carbon chains (≤C3). The enzyme shows increased activity of 150% in 40% DMSO and 123% in 30% methanol. The L-haloacid dehalohenase crystal complex structure with covalently bound MCP confirmed Asp 18 as the main catalytic residue. Residues His 183, Asp 186 and Glu 21 in the active site are proposed to be involved in activation of the catalytic water which attacks the ester intermediate in the second part of the SN2 dehalogenase mechanism. The AQP5750 haloalkane dehalogenase has been cloned, over-expressed in a bacterial expression system, crystallized and the native and complex structure with 1-hexanol has been determined. Substrate specificity experiments showed that the haloalkane dehalogenase from AQP5750 does not show high activity towards substrates used by other haloalkane dehalogenases with high amino acid sequence identity. The large active site cavity and the presence of Ser 176 and Arg 136 in the hydrophobic binding pocket may alter the binding of substrates tested which could account for the low activity observed.
IN VITRO PRODUCTION AND SPECIFICITY OF ANTI-DNA AUTO ANTIBODIES BY NEW ZEALAND BLACK/NEW ZEALAND WHITE F1 MICE

The New Zealand Black/ New Zealand White F1 (B/W) mice are animal models for human systemic lupus erythematosus (SLE). The female mice die early in life from glomerulonephritis caused by deposition of immune complexes which consist of antibodies reactive with DNA. Studies that have been done on the specificity of anti-DNA antibodies have used either sera which is a heterogeneous population of antibodies or monoclonal antibodies from hybridomas which may not be true representa­ tives of in vivo clonal populations. Therefore, another approach was used in this study in which spleen cells of B/W mice of different ages were stimulated in vitro with DNA and the production and specificity of the resulting antibodies was studied using modified Elisa method. Direct correlation was observed between the age of the mice and the anti-DNA antibody production in vitro, and serum titer of anti-DNA antibodies. Fewer cells were needed from older mice to produce detectable antibody, indicating the presence of more anti-DNA antibody producing clones. The antibodies produced had high specificity to single stranded and double stranded DNA but tRNA did not stimulate antitRNA antibody production. The B/W spleen cells were able to release anti-DNA antibodies in vitro without DNA stimulation indicating that clones exist in these mice that spontaneously release anti-DNA antibodies. Upon stimulation with DNA the production of anti-DNA antibodies was increased.
Production of monoclonal antibodies to bud necrosis virus

The bud necrosis disease of groundnut (Arachis hypogaea L.) was first reported from India by Reddy et al. (1968). It was subsequently reported that bud necrosis disease was caused by tomato spotted wilt virus (TSWV) (Ghanekar et al. 1979). Recent studies using advanced serological techniques have shown that the causal agent of bud necrosis disease is distinct from TSWV and it has therefore been named bud necrosis virus (BNV) (Sreenivasulu et al. 1991, Reddy et al. in press). Hence BNV is considered to be a distinct member of the tospovirus group
Impacting Factors on Student Volunteers at the Academic Library

This study is aimed at identifying the impacting factors on student volunteers at an academic library in the Mekong Delta, Vietnam. Underpinned by the conceptual framework of volunteer and volunteering defined by Wilson (2000),the study was carried out using quantitative methods. Through emails and in-person meetings, a survey questionnaire was delivered to all volunteers in the LRC. There were 100 responses which reach the ideal samples as noted by Hair and his colleagues (2009). Data collected in this study were analyzed using SPSS with Cronbach’s Alpha, Exploratory Factor Analysis and multivariate regression to determine factors influencing students' decisions and their impacting level to volunteer at the library. Research findings indicate two factors influencing on student volunteering are experiences and relationships. An evaluation research on quality of student volunteering will be proposed to further research, so as to get further information about how productively the student volunteers can support their library. This study fills the gap by examining the impacting factors on volunteering that benefits the LRC and volunteering students. As a result of this influence, students are expected to know more about benefits and responsibilities of volunteering at the library, thereby obtaining greater experience, communication ability and confidence in their future work and life. This research contributes to literature about impacting factors on the student volunteers at the academic library in an Asian country context, which has not been discussed so far. It also provides possible solutions to attract and retain the student force for the library functions.
Characterization and Variable Expression of the CslF6 Homologs in Oat (Avena sp.)

Characterization and Variable Expression of the CslF6 Homologs in Oat (Avena sp.) Melissa Coon Department of Plant and Wildlife Sciences, BYU Master of Science (1,3;1,4)-βD-glucan (β-glucan) is a plant cell wall hemicellulose and a main component of endosperm cell walls. The Cellulose Synthase F family of genes is involved in the synthesis of β-glucan. In this study full-length genomic sequences of CslF6 were obtained from multiple Avena species. Three unique alleles were found in each A. sativa line. Comparisons of these alleles to diploid Avena species allowed for identification of the genomic origin of each allele. The A and D genome alleles had identical amino acid sequences while the C-genome had 13 different amino acids. Global expression of CslF6 was completed at three developmental time point and three tissue types. RNAseq technology was utilized to determine genome specific expression patterns. Differential expression of genome specific-copies of CslF6 was found at all time points tested. Lower levels of C-genome expression of CslF6 were associated with increased levels of B-glucan.
Symptom Experiences and Symptom Management among Persons with Lung Cancer in Bangladesh

Objective: Lung cancer is one of the most common cancers. Previous studies findings are not suitable to explain symptom experience and symptom management of Bangladeshi persons with lung cancer. This study was aimed to identify the symptom experiences and determines the management strategies among persons with lung cancer. Methods: A descriptive study design, using combined both quantitative and qualitative research methods, was chosen for this study. Convenient sampling was used to recruit 382 persons with lung cancer from two public and two private tertiary hospitals and 16 participants were invited for an in-depth interview in the qualitative part. Data collection was conducted from October 2015 to July 2016, using the MD Anderson Symptom Inventory Lung Cancer (MDASI-LC) questionnaire and using a semistructured interview guide to explore their symptom management strategies. The quantitative data were analyzed using descriptive and inferential statistics and qualitative data by content analysis. Results: Pain was the most frequently reported physical symptom and the most severe one, followed by sleep disturbance and fatigue. Psychological symptoms such as sadness and distress were also frequent. Participants also reported other symptoms that interfered with daily living in terms of mood, general activity, work, enjoyment of life, walking and relationships with others. The symptom management consisted of three categories, which were taking modern medicine, adopting complementary therapies, and cultivating mind and body balance. Most of the participants addressed uses of more than one strategy. Conclusions: Participants experienced several physical and psychological symptoms that interfered with their lives. This finding will be beneficial for health care personnel regarding clinical practice to manage symptoms and further research may be conducted to obtain proper interventions to alleviate symptoms, and improve quality of life.
Legal aspects and support instruments for social entrepreneurship in the Baltic States

Social entrepreneurship plays an increasing role in society. It is evidenced not only by the inclusion of a section on social entrepreneurship in the Europe 2020 strategy but also by the engagement of European countries in making legal documents on social entrepreneurship as well as designing support programmes in order to help entrepreneurs to start up a social entrepreneurship business. The research aim is to characterise the legal aspects of social entrepreneurship and support instruments for the promotion of social entrepreneurship in the Baltic States. In order to achieve the aim, the research analysed legal acts and strategic policy documents regulating social entrepreneurship in Latvia as well as analysed the legal framework for social entrepreneurship in Lithuania. To do the analysis, the research examined the kinds of support for starting up a social entrepreneurship business in the Baltic States. The research has found that no uniform definition of social entrepreneurship is available in Europe, which does not result in a unanimous opinion on what a social enterprise should be. In the Baltic States, the Social Enterprise Law has been passed in Latvia and Lithuania; besides, the laws mainly focus on the integration of target groups into society, addressing no other essential problems that could be solved by means of social entrepreneurship, e.g. environmental protection.
Growth factor priming of murine mesenchymal stem cells critically determines their functionality

Mesenchymal stem cells (MSCs) are a subset of multipotent cells with a variety of trophic and immunosuppressive functions. Isolation of murine MSCs has traditionally been hampered by the presence of contaminating cells in culture. In this study, I prospectively isolate murine MSCs based on the co-expression of platelet-derived growth factor (PDGF) receptor alpha and stem cell antigen‐1 (PαS MSCs) and present novel data regarding their \(in\) \(vitro\) phenotype, karyotype and immunomodulatory functions. However, PαS MSCs undergo senescence after extended culture, resulting in a loss of function. Addition of fibroblast growth factor 2 (FGF2), PDGF‐BB or transforming growth factor-beta 1 (TGF-β1) was able to overcome senescence in MSC cultures. These factors also ‘lineage primed’ MSCs down specific fates at the genetic and phenotypic levels, with un‐supplemented MSCs primed towards bone, FGF2 or PDGF‐BB supplemented cells primed towards fat, and FGF2 supplemented cells primed towards cartilage. TGF‐β1 supplementation attenuated tri‐lineage differentiation of PαS MSCs but maintained their immunosuppressive functions. These findings were confirmed in a mouse model of inflammatory liver injury, with late‐passage TGF‐β1 MSCs improving liver injury compared to controls. In summary, these results have significant translational relevance as I reveal that culture conditions can functionally ‘prime’ MSCs down specific fates.
Developing and Applying IR-Tree Models: Guidelines, Caveats, and an Extension to Multiple Groups

IR-tree models assume that categorical item responses can best be explained by multiple response processes. In the present article, guidelines are provided for the development and interpretation of IR-tree models. In more detail, the relationship between a tree diagram, the model equations, and the analysis on the basis of pseudo-items is described. Moreover, it is shown that IR-tree models do not allow conclusions about the sequential order of the processes, and that mistakes in the model specification can have serious consequences. Furthermore, multiple-group IR-tree models are presented as a novel extension of IR-tree models to data from heterogeneous units. This allows, for example, to investigate differences across countries or organizations with respect to core parameters of the IR-tree model. Finally, an empirical example on organizational commitment and response styles is presented.
Does Prenatal WIC Participation Improve Child Outcomes?

A large body of literature documents positive effects of the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) on birth outcomes, and separately connects health at birth and future outcomes. But little research investigates the link between prenatal WIC participation and childhood outcomes. We explore this question using a unique data set from South Carolina that links administrative birth, Medicaid, and education records. We find that relative to their siblings, prenatal WIC participants have a lower incidence of ADHD (attention-deficit/hyperactivity disorder) and other common childhood mental health conditions and a lower incidence of grade repetition. These findings demonstrate that a “WIC start” results in persistent improvements in child outcomes across a range of domains.
Unpacking the dynamics of collegial networks in relation to beginning teachers’ job attitudes

ABSTRACT Previous research has pointed at the pivotal role of professional collegial support relationships to keep beginning teachers in the profession. In this study, we build on previous research by using follow-up mixed-method social network data to explore (1) to what extent, in what ways and for which reasons beginning teachers’ work-related network (position) changes throughout a school year, and (2) how the network (position) of beginning teachers influences their job attitudes, as important precursors of teacher retention. Five follow-up case-studies of beginning teachers and their school teams were explored. The network data showed that some teachers had a central and stable position in their team, while others were more peripheral and showed considerable changes in their work-related relations. The interviews with the beginning teachers revealed several reasons for the formation, loss and retention of their work-related ties, such as physical proximity, network intentionality and the presence of a staffroom. Finally, the results indicated that the professional support in these work-related ties can play an important role in beginning teachers’ job attitudes, or can act as a mitigating factor in case of experienced challenges. In this respect, the structural and cultural conditions needed for teachers to professionally connect require our attention.