Miracle-dz/UniFAR-FTUs huggingface dataset:
III-Nitride nanophotonics for beyond-octave soliton generation and self-referencing

Frequency microcombs, successors to mode-locked laser and ﬁber combs, enable miniature rulers of light for applications including precision metrology, molecular ﬁngerprinting and exoplanet dis-coveries. To enable frequency ruling functions, microcombs must be stabilized by locking their carrier-envelop oﬀset frequency. So far, the microcomb stabilization remains compounded by the elaborate optics external to the chip, thus evading its scaling beneﬁt. To address this challenge, here we demonstrate a nanophotonic chip solution based on aluminum nitride thin ﬁlms, which simultaneously oﬀer optical Kerr nonlinearity for generating octave soliton combs and Pockels nonlinearity for enabling heterodyne detection of the oﬀset frequency. The agile dispersion control of crystalline III-Nitride photonics permits high-ﬁdelity generation of solitons with features including 1.5-octave spectral span, dual dispersive waves and sub-terahertz repetition rates down to 220 gigahertz. These attractive characteristics, aided by on-chip phase-matched aluminum nitride waveguides, allow the full determination of the oﬀset frequency. Our proof-of-principle demonstration represents an important milestone towards fully-integrated self-locked microcombs for portable optical atomic clocks and frequency synthesizers.
Identification and Characterization of De Novo-Synthesized Porcine Oviductal Secretory Proteins1

Oviductal secretory products provide a biochemical environment important for establishment of pregnancy. A previous study identified three de novo-synthesized glycoproteins by one-dimensional SDS-PAGE as well as increased incorporation of [‘H]Leu into secretory protein by whole oviduct and ampulla associated with proestrus, estrus, and metestrus only. Here, our objective was to fiarther identify and characterize oviductal secretory proteins, specifically 115 000- and 85 000(cid:1)Mr estrus-associated proteins (EAP). Two-dimensional SDS-PAGE resolved the 115 000-M, protein into two proteins of 100 000 M,, one basic and one acidic, and the 85 000-M, protein into 75000-and 85 000-M, species (p1 < 4.0). Differential secretion of proteins between ampulla and isthmus was indicated. The 100 000-, 75000-, and 85 000-M, proteins were synthesized by ampulla during estrus but not by isthmus nor by uterine endometrium. De novo-synthesized EAP were labeled with glucosamine, Leu, and Met, and the 75000-85 000-M, proteins from ampulla and a 30 000-M, family from isthmus were labeled with flicose. Inorganic (“5)sulfatc labeled three EAP. Fractionation of culture medium by gel ifitration demonstrated differences between products secreted by ampulla and Isthmus and suggested that some EAP may be found as high-molecular weight forms in the native state. Results indicate that porcine oviductal tissue synthesizes specific EAP at the time of fertilization and early cleavage-stage embryonic development, that there are differences in the type and distribution of glycoproteins from ampulla and isthmus, and that post-translational modifications occur with the addition of glucosamine, fucose, and inorganic sulfate. synthesis by porcine oviduct and by ampulla and isthmus during the estrous cycle. studies understanding the function of the oviduct and its functional segments.
Simpler proof of the theorem by Pusey, Barrett, and Rudolph on the reality of the quantum state

The theorem of Pusey, Barrett, and Rudolph proves that different quantum states describe different physical realities. Their proof is based on the construction of entanglement measurement bases of two, and more than two qbits. In this note, I show that a two-qubit entanglement base is sufficient for a general proof.
MOLECULAR POINT-OF-CARE DIAGNOSTIC FOR TREPONEMA PALLIDUM SUBSP. PERTENUE (YAWS)

Author: Basing, Laud Anthony W. MSBME Institution: Purdue University Degree Received: May 2019 Title: A Molecular Point of Care Diagnostic for Treponema pallidum subspecies pertenue(yaws). Committee Chair: Linnes Jacqueline Yaws is a neglected tropical disease caused by Treponema pallidum subsp. pertenue, which affects children living in very deprived hard to reach rural communities. Infection with yaws, if untreated could lead to gross deformities and disabilities. Yaws can be treated effectively with a single dose of azithromycin and the World Health Organization has earmarked yaws for eradication by the year 2020. The eradication of yaws however is constrained by the lack of rapid, accurate diagnosis. I sought to develop a molecular point-of-care test for the diagnosis of yaws. A Loop-mediated isothermal amplification (LAMP) assay with primers targeting the conserved gene, tp0967, with visual detection by lateral flow test strip was developed and optimized. The limit of detection was evaluated while 63 samples from clinical cases of yaws and 5 samples with PCR-confirmed syphilis were used to determine the sensitivity and specificity of the assay compared to the current molecular testing protocol. Reagents were dried in tubes and tested up to 14 days. The developed LAMP assay was found to be optimal when run at 65C in a water bath for 30 minutes. The limit of detection was 2.7*10 DNA copies/ml. The sensitivity of the LAMP assay using unextracted and DNA extracted samples were 0.67 and 1.00 respectively. None of the syphilis samples tested positive in any of the assays. We show the development of a fast and sensitive LAMP assay for yaws detected by lateral flow test strip. Using extracted DNA, the assay sensitivity is at par with gold standard detection. The assay can be adapted to minimal sample processing required for infield detection without DNA extraction.
Closest conjunct agreement with attributive adjectives 1

Contrary to most French grammars claiming that French only allows masculine agreement when mixed-gender nouns are conjoined, we show that closest conjunct agreement (CCA) does exist in contemporary French, as in other Romance languages, and is the preferred strategy for prenominal adjectives. Using data from a large corpus (FrWac) and an acceptability rating experiment, we show that (feminine) CCA is well accepted in contemporary French, and should be distinguished from attraction errors, despite the norm prescribing masculine agreement. We also show the role of the adjective position, i.e. prenominal or post-nominal, and humanness. CCA is the preferred strategy for prenominal adjectives, and non-human nouns favour CCA for postnominal adjectives. Assuming a hierarchical structure for coordination, the closest noun is the highest in A-N order, whereas it is the lowest in N-A order. Thus CCA in prenominal position may be favoured by a shorter structural distance. One can also see CCA with a prenominal adjective as ‘ early ’ agreement. Regarding humanness, grammatical gender is interpreted as social gender with human nouns, and a masculine plural can refer to a mixed group. This ‘ gender neutral ’ plural may favour masculine agreement for human nouns, or the prescriptive norm is more influential for human nouns.
Effective Integration of E government across Dutch municipalities

The aim of this research is to construct an understanding of the variables that influences the development of local E governments. There is a lack of knowledge in which variables limits the local governmental bodies in The Netherlands in specific. Through an exploratory research design in which interviews are conducted with experts in the development of local E governments, new insights have been gathered. Through a judgement sampling design, interviewees are selected to gather the necessary data to come to the conclusions. The interviews have shown there are different variables to take into consideration, such as the specific characteristics of the city: whether it is a student or a tourist city for instance. Besides that, regulations concerning privacy and the high level of customization make it harder to standardize processes in the local E government. Due to the limited number of interviewees, the reliability of this research is low, however it gives deeper insights in the case study of the municipality in Roosendaal. Further research with a different sampling design, adding municipalities with a different focus (e.g. tourism and students), should be considered. Throughout this paper E government will be used for electronic government.
Extricating Opinion Word from Review Based on Word Alignment Model Using Topical Lexicon

: Social media is one of the biggest forums to express opinions. Sentiment analysis is the procedure by which information is extracted from the opinions, appraisals of people in regards to entities, events and their attributes. Sentiment analysis is also known as opinion mining. Opinion Mining is to analyze and classify the user generated data like reviews, blogs, comments, articles, etc. Mining opinions and sentiments from natural language are a challenging task. The systems continuously gather a wide array of information from the Web, such as product reviews, brand perception and political issues. Other systems might also use opinion mining and sentiment analysis as subcomponent technology to improve customer relationship management and recommendation systems through positive and negative customer feedback. To this end, this paper proposes an access control mechanism using copyright policy attribute based algorithm to enforce access control policy with efficient attribute and user revocation capability and also proposed a Partially supervised alignment model identifying the relationship between co-occurrence of opinion relation. Opinion words usually co-occur with opinion targets and there are strong modification relations and associations among them (opinion relations or opinion associations). Therefore, many methods jointly extracted opinion targets and opinion words in a bootstrapping manner. Compared to previous algorithm copyright policy is more secure one.
Prognostic Value of Programmed Death Ligand-1 Expression on Tumor-Infiltrating Immune Cells in Patients Treated with Cisplatin-Based Combination Adjuvant Chemotherapy Following Radical Cystectomy for Muscle-Invasive Bladder Cancer: A Retrospective Cohort Study

Purpose: To investigate the prognostic value of programmed death ligand-1 (PD-L1) expression in tumor-infiltrating immune cells (ICs) in men treated with adjuvant chemotherapy (AC) following radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC). Materials and Methods: We retrospectively reviewed 219 “high-risk” (≥pT3a and/or pN+) patients who underwent RC and received cisplatin-based AC for MIBC between March 2015 and September 2019. PD-L1 expression was measured using the VENTANA (SP-142) immunohistochemistry assay and categorized into the three groups according to the percentage of the tumor area covered by PD-L1 expression on ICs: IC0 (<1%), IC1 (≥1% and <5%), and IC2/3 (≥5%). Positive PD-L1 expression was defined as IC2/3 (≥5%). Kaplan– Meier survival analysis was used to assess recurrence-free survival (RFS), and Cox proportional hazard models were applied to identify factors predicting tumor recurrence. Results: In the entire cohort, the overall prevalence of PD-L1 IC0, IC1, and IC2/3 was 13.2%, 27.4%, and 59.4%, respectively. During the mean follow-up of 32.5 months, tumor recurrence was detected in 115 (52.5%) patients. On multivariable analysis, tumor stage (≥pT3; P =0.032), positive lymph nodes ( P =0.001), and positive PD-L1 on ICs ( P =0.005) were independent predictors of tumor recurrence. The 3 year RFS was 54.7% in patients with negative PD-L1 and 31.7% in patients with positive PD-L1. Conclusion: PD-L1 is widely expressed in ICs. Positive PD-L1 on ICs was significantly associated with shorter RFS in patients treated with cisplatin-based AC following RC. The present results support the use of adjuvant immunotherapy in “high-risk” patients with PD-L1-expressing ICs.
Inverse thermal problems

There has been a substantial increase in the use of mathematical methods for modelling in engineering sciences. Amongst a variety of problems to have been solved sucessfully, are inverse problems. Inverse thermal problems involve the evaluation of boundary or initial conditions as well as thermal properties of a body from the remaining boundary, or some internal, conditions. This encompasses thermal designing, process controlling, optimum planning of experiments and experimental results interpretation. The success of any method for solving inverse problems lies not only in using elegant mathematical formulae but also in the stability of results when experimental data are used. This book presents a comprehensive study of efficient methods for solving inverse thermal problems.
DEMODULATION AND DENOISING TECHNIQUES FOR A MULTIPLEXED FIBRE FIZEAU INTERFEROMETER AND FIBRE BRAGG GRATING SENSOR SYSTEM BASED ON WAVELET ANALYSIS

Wavelet analysis is applied extensively to a multiplexed fibre Fizeau interferometer and fibre Bragg grating sensor system. Specifically, the discrete wavelet transform is used to demodulate the multiplexed sensor signal simultaneously; and two wavelet denoising methods are used to reduce the noise present in the signal and measurands record. Experimental demonstration is performed through the simultaneous measurement of quasi-static strain and temperature.
MEASUREMENT OF A WALL-BOUNDED TURBULENT MIXING LAYER FLOW

Turbulence properties of a wall-bounded turbulent mixing layer associated with an opening step were extensively measured using I- and X-type hotwires. The turbulent mixing layer flow was analyzed in terms of wall static pressure distribution, turbulence intensity, Reynolds stress, streamwise velocity profile and continuous wavelet transform coefficients. Development of vortical structures embedded in the turbulent mixing layer was temporally and spatially resolved by using continuous wavelet transform. The constraint of the downstream solid wall on the mixing layer flow was delineated.
Spleen metastases secondary to gastric neuroendocrine carcinoma: case report

Neuroendocrine carcinoma (NEC) in the stomach represents a rare and rapidly growing type of gastric tumors. They are considered a distinct entity of neuroendocrine tumors characterized by an aggressive behavior and high metastases rate. On the other hand, spleen metastases of neuroendocrine tumors are extremely rare. We report the first case of spleen metastases of gastric neuroendocrine carcinoma. The patient was a 54-year-old male who presented with a 10-month history of epigastralgia. Upper gastro-intestinal endoscopy revealed a 5 cm ulcerative lesion located in the greater gastric curvature. Biopsies with immunohistochemical staining revealed gastric neuroendocrine carcinoma. Abdominal computed tomography showed thickening of the stomach with two large solid spleen lesions. Abdominal Magnetic Resonance Imaging and 18-fluorodexyglucose positron-emission tomography revealed peritoneal carcinosis and splenic metastases with splenic vein invasion. Clinicians should keep in mind that splenic metastases can arise from gastric neuroendocrine tumors (NETs).
Relative Effectiveness of Influenza Vaccines Among the United States Elderly, 2018–2019

Background. Studies among individuals ages ≥ 65 years have found a moderately higher relative vaccine effectiveness (RVE) for the high-dose (HD) influenza vaccine compared with standard-dose (SD) products for most seasons. Studies during the A(H3N2)-dominated 2017–2018 season showed slightly higher RVE for the cell-cultured vaccine compared with SD egg-based vaccines. We investigated the RVE of influenza vaccines among Medicare beneficiaries ages ≥ 65 years during the 2018–2019 season. Methods. This is a retrospective cohort study using inverse probability of treatment weighting and Poisson regression to evaluate RVE in preventing influenza hospital encounters. Results. Among 12 777 214 beneficiaries, the egg-based adjuvanted (RVE, 7.7%; 95% confidence interval [CI], 3.9%–11.4%) and HD (RVE, 4.9%; 95% CI, 1.7%–8.1%) vaccines were marginally more effective than the egg-based quadrivalent vaccines. The cell-cultured quadrivalent vaccine was not significantly more effective than the egg-based quadrivalent vaccine (RVE, 2.5%; 95% CI, −2.4% to 7.3%). Conclusions. We not find major effectiveness differences between licensed vaccines used among the elderly during the 2018–2019 season. Consistent with prior research, we found that the egg-based adjuvanted and HD vaccines were slightly more effective than the egg-based quadrivalent vaccines.
Competitive Fitness of Inﬂuenza B Viruses with Neuraminidase Inhibitor-Resistant Substitutions in a Coinfection Model of the Human Airway Epithelium

Inﬂuenza A and B viruses are human pathogens that are regarded to cause almost equally signiﬁcant disease burdens. Neuraminidase (NA) inhibitors (NAIs) are the only class of drugs available to treat inﬂuenza A and B virus infections, so the development of NAI-resistant viruses with superior ﬁtness is a public health concern. The ﬁtness of NAI-resistant inﬂuenza B viruses has not been widely studied. Here we examined the replicative capacity and relative ﬁtness in normal human bronchial epithelial (NHBE) cells of recombinant inﬂuenza B/Yamanashi/166/1998 viruses containing a single amino acid substitution in NA generated by reverse genetics (rg) that is associated with NAI resistance. The replication in NHBE cells of viruses with reduced inhibition by oseltamivir (recombinant virus with the E119A mutation generated by reverse genetics [rg-E119A], rg-D198E, rg-I222T, rg-H274Y, rg-N294S, and rg-R371K, N2 numbering) or zanamivir (rg-E119A and rg-R371K) failed to be inhibited by the presence of the respective NAI. In a ﬂuorescence-based assay, detection of rg-E119A was easily masked by the presence of NAI-sus-ceptible virus. We coinfected NHBE cells with NAI-susceptible and -resistant viruses and used next-generation deep sequencing to reveal the order of relative ﬁtness compared to that of recombinant wild-type (WT) virus generated by reverse genetics (rg-WT): rg-R371K. Based on the lack of attenuated replication of rg-E119A in NHBE cells in the presence of oseltamivir or zanamivir and the ﬁtness advantage of rg-H274Y over rg-WT, we emphasize the importance of these substitutions in the NA glycoprotein. Human infections with inﬂuenza B viruses carrying the E119A or H274Y substitution could limit the therapeutic options for those infected; the emergence of such viruses should be closely monitored.
GSK-3 (cid:1) activity is increased in skeletal muscle after burn injury in rats

activity is increased in skeletal muscle after burn injury in rats. Am Physiol Regul Integr Comp Physiol 293: 2007. doi:10.1152/ajpregu.00244. 2007. —Previ-ous reports suggest that burn-induced muscle proteolysis can be inhibited by treatment with GSK-3 (cid:1) inhibitors, suggesting that burn injury may be associated with increased GSK-3 (cid:1) activity. The inﬂuence of burn injury on muscle GSK-3 (cid:1) activity, however, is not known. We determined the effect of a 30% total body surface full-thickness burn injury in rats on muscle GSK-3 (cid:1) activity by measuring GSK-3 (cid:1) activity and tissue levels of serine 9 phosphorylated GSK-3 (cid:1) , p(Ser9)-GSK-3 (cid:1) , by Western blot analysis and immunohistochemistry. Because burn-induced muscle wasting is, at least in part, mediated by glucocorticoids, we used dexamethasone-treated cultured muscle cells in which GSK-3 (cid:1) expression was reduced with small interfering RNA (siRNA) to further assess the role of GSK-3 (cid:1) in muscle atrophy. Burn injury resulted in a seven-fold increase in GSK-3 (cid:1) activity in skeletal muscle. This effect of burn was accompanied by reduced tissue levels of p(Ser9)-GSK-3 (cid:1) , suggesting that burn injury stimulates GSK-3 (cid:1) in skeletal muscle secondary to inhibited phosphorylation of the enzyme. In addition, burn injury resulted in inhibited phosphorylation and activation of Akt, an upstream regulatory mechanism of GSK-3 (cid:1) activity. Reducing the expression of GSK-3 (cid:1) in cultured muscle cells with siRNA inhibited dexamethasone-induced protein degradation by (cid:2) 50%. The results suggest that burn injury stimulates GSK-3 (cid:1) activity in skeletal muscle and that GSK-3 (cid:1) may, at least in part, regulate glucocorticoid-mediated muscle wasting. [ 3 H]- L -tyrosine/ml for 48 h in DMEM containing 2% FBS followed by treatment with or without 1 (cid:3) M dexamethasone for 6 h. Protein degradation was determined by measuring the release of TCA-soluble radioactivity and expressed as a percentage of proteins degraded during 6 h, as described in detail previously (24, 37). A parallel set of transfected cells was treated with or without dexamethasone for 6 h and then lysed using RIPA buffer supplemented with protease and phosphatase inhibitors (Santa Cruz Biotechnology, Santa Cruz, CA). Total protein was extracted and used for determination of GSK-3 (cid:1) levels by immunoblotting. Statistics. Results are reported as means (cid:10) SE. ANOVA followed by a Tukey test was used for statistical analysis; P (cid:11) 0.05 was considered statistically signiﬁcant.
AIS Electronic Library (AISeL)

Many studies have looked at the factors that control the productivity of collaborative work. We claim that goal commitment and competition have a strong impact on group productivity in collaborative modelling. To substantiate this claim we first take a look at existing factor models to identify the factors that potentially mediate the effect on group productivity. We then investigate the relation between the factors with the help of controlled field experiments in five different organisations. We confirm the theoretical results with the help of structured equation modelling.
Kaposi’s Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 3 Inhibits Gamma Interferon and Major Histocompatibility Complex Class II Expression (cid:1) †

Kaposi’s sarcoma-associated herpesvirus (KSHV) carries four genes with homology to human interferon regulatory factors (IRFs). One of these IRFs, the viral interferon regulatory factor 3 (vIRF-3), is expressed in latently infected primary effusion lymphoma (PEL) cells and required for their continuous proliferation. Moreover, vIRF-3 is known to be involved in modulation of the type I interferon (IFN) response. We now show that vIRF-3 also interferes with the type II interferon system and antigen presentation to the adaptive immune system. Starting with an analysis of the transcriptome, we show that vIRF-3 inhibits expression of major histocompatibility complex class II (MHC II) molecules: small interfering RNA (siRNA)-mediated knockdown of vIRF-3 in KSHV-infected PEL cell lines resulted in increased MHC II levels; overexpression of vIRF-3 in KSHV-negative B cells leads to downmodulation of MHC II. This regulation could be traced back to inhibition of class II transactivator (CIITA) transcription by vIRF-3. Reporter assays revealed that the gamma interferon (IFN- (cid:1) )-sensitive CIITA promoters PIV and PIII were inhibited by vIRF-3. Consistently, IFN- (cid:1) levels increased upon vIRF-3 knockdown in PEL cultured as described previously (55). HEK293T cells were obtained from the ATCC and grown in Dulbecco’s modiﬁed Eagle’s medium supplemented with 10% fetal calf serum (FCS). Jurkat T cells (E6.1; ATCC; TIB-152) were maintained in RPMI 1640 medium (Invit-rogen) supplemented with 10% fetal bovine serum (Invitrogen), glutamine, and gentamicin. Cells from the multiple myeloma-derived cell line INA-6 (7)