Miracle-dz/UniFAR-FTUs huggingface dataset:
Crystal structure of tofacitinib dihydrogen citrate (Xeljanz®), (C16H21N6O)(H2C6H5O7)

The crystal structure of tofacitinib dihydrogen citrate (tofacitinib citrate) has been solved and refined using synchrotron X-ray powder diffraction data, and optimized using density functional techniques. Tofacitinib dihydrogen citrate crystallizes in space group P212121 (#19) with a = 5.91113(1), b = 12.93131(3), c = 30.43499(7) Å, V = 2326.411(6) Å3, and Z = 4. The crystal structure consists of corrugated layers perpendicular to the c-axis. Within the layers, cation⋯anion and anion⋯anion hydrogen bonds link the fragments into a two-dimensional network parallel to the ab-plane. Between the layers, there are only van der Waals contacts. A terminal carboxylic acid group in the citrate anion forms a strong charge-assisted hydrogen bond to the ionized central carboxylate group. The other carboxylic acid acts as a donor to the carbonyl group of the cation. The citrate hydroxy group forms an intramolecular charge-assisted hydrogen bond to the ionized central carboxylate. Two protonated nitrogen atoms in the cation act as donors to the ionized central carboxylate of the anion. These hydrogen bonds form a ring with the graph set symbol R2,2(8). The powder pattern has been submitted to ICDD® for inclusion in the Powder Diffraction File™ (PDF®).
ROMANIAN RURAL TOURISM IN THE CONTEXT OF SUSTAINABLE DEVELOPMENT. PRESENT AND PROSPECTS

Today’s Romanian tourists do not seem to clearly differentiate one type of accommodation facility from another. Given this, the hospitality services providers either intentionally or by mistake promote their units as a different type than the one they are registered and classified under. Perhaps this is why boarding houses or villas are promoted online as hotels or why concrete villas replace rural boarding houses and invade and disrupt rural landscapes. Moreover, with an inadequate and incomplete situation of Romania’s accommodation establishments, doubled by a weak legal framework regarding the development of lodging facilities, it becomes merely impossible to keep the development of the supply under control. In this context, when most of the most popular types of accommodation facilities present in Romania seem to have lost their identity, we have identified tourist inns as a potential breath of rural authenticity. Making use of an analysis grid, a website-based investigation is run among the accommodation facilities identified as more or less related to tourist inns. The main purpose of our research is to determine the extent to which these lodgings can contribute to the authenticity of the Romanian rural tourism.
10_V3_JORDAN_PIEB_Arqam Rabbaie and Alwaked

The underlying employment trend (UET) is investiga ted in Jordanian economy over the period 19892004 using structural time series model (STSM). This app roach allows to modelling the trend in its stochast ic form introduced by Harvey (1989). The results show that a stochast ic trend is preferred to deterministic trend. In ad dition, the inclusion or exclusion of the conventional deterministic trend l eads to overestimated output elasticity. Furthermor e, the UET is found to be non-linear, down downward sloping. ISSN: 1804-0527 (online) 1804-0519 (print) PP. 35-37
Testing a Neoclassical Growth Model with the Institution Effect of Government Size: a Dynamic Panel Data Model

This paper develops and tests a Neoclassical growth model with the institution effect of government size in the framework of a dynamic panel data model, using two Generalized method of moments (GMM) estimators to address endogeneity of explanatory variables in estimation. I find a robust significant negative correlation between government size and economic growth for all OECD countries between 1960 and 2012, with much higher estimates of growth elasticity of government expenditure, tax revenue and total welfare than those obtained in previous empirical studies on this subject. The estimated convergence speed is consistent with those obtained from other growth studies using panel data and the implied capital share is close to one third of real value. Although the negative correlation does not necessarily imply causality, tax revenue as a percentage of GDP is identified as having causal negative impact on growth. This correlation or causality also applies to Nordic countries. The evidences strongly suggest that the economic success of Nordic countries in terms of growth is not due to welfare state characterized by big government, high tax and high welfare, but attributed to other time-invariant and time-varying institutional or policy factors. In the long run, whether Nordic characteristics that are in favor of growth can keep on dominating the negative growth effect of welfare state is still an open question.
Private Placements of Public Equity in China

In this study of private equity placements (PEPs) in China, we find that Chinese firms’ PEPs are issued at a substantial discount and have positive announcement period returns, which is consistent with previous studies using data mainly from the United States and Europe. However, there is a long-term outperformance by PEP-issuing firms, and such long-term abnormal return is even higher when controlling shareholders participate in the deal and the externally raised capital is allocated to asset restructuring and M&A. We further show that firms approved for private placements are financially stronger than those rejected by regulatory authorities. In addition to the benefits accruing to investors, investment efficiency is improved after private placements, especially in firms that had financial constraints to begin with. Overall the evidence suggests that the policy preferences of market regulators influence the allocation of capital to the corporate sector.
SOEPpapers 325: German male earnings volatility

Deploying data from the German Socio-Economic Panel (SOEP) we analyze the variability of individual earnings and equivalent household income. Permanent and transitory variances of male income over the period 1984-2008 are estimated for Old German Laender in order to determine their importance to income dynamics. To uncover the role of the welfare state in smoothening earnings shocks we compute different income concepts reaching from gross earnings to net equivalent household income. We find evidence that the overall inequality of earnings in Germany has been rising throughout the period due to both higher permanent inequality and higher volatility. However, taking the welfare state and its institutions into account, we find that net household income has remained fairly stable.
The trend towards the development and liberalization of equity markets in developing countries has raised a number of issues for the conduct of economic policy. Understanding

This paper seeks to investigate the institutional determinants of emerging market microstructures. After a brief discussion of the economic implications of microstructures, we develop six recursive annual indicators of informational efficiency, market volatility and transaction costs, using daily data for a panel of 27 emerging markets over the 1996-2006 period. We then analyze the impact of market development variables and specific reform dates on those indicators with panel regressions. Overall, our results suggest that emerging market microstructures (i) are affected by economic and political context (ii) are strongly related to one another and (iii) are positively impacted by market size, domestic financial sector development and the modernization of trading systems. JEL classification: G11;G12;G15
Hofmeister series at the liquid/liquid interface

OF THE DISSERTATION . ii DEDICATION. v ACKNOWLEDGEMENTS . vi TABLE OF CONTENTS . vii LIST OF FIGURES . x LIST OF TABLES . xvi Chapter 1 General Introduction . 1 1.1 HOFMEISTER SERIES . 1 1.1.
The complete mitochondrial genomes of Gobiobotia meridionalis (Cypriniformes: Cyprinidae)

Abstract In this study, we sequenced the complete mitogenome of Gobiobotia meridionalis (Chen et Tsao, 1982). The genome is 16,609 base pair (bp) in length, encoding 13 protein-coding genes (PCGs), 22 tRNA genes, 2 rRNA genes, and 1 non-coding control region (D-loop). The nucleotide composition is A: 30.34%, T: 26.88%, G: 16.49%, and C: 26.29% (AT content: 55.22%). The complete mitogenome of G. meridionalis provides essential and important DNA molecular data for the genetic diversity conservation of this species.
Association of the Ratio of Triglycerides to High-Density Lipoprotein Cholesterol Levels with the Risk of Type 2 Diabetes: A Retrospective Cohort Study in Beijing

Background Previous studies have shown that the ratio of triglyceride to high-density lipoprotein cholesterol level (TG/HDL-C) is a risk factor for type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the nonlinear relationship between TG/HDL-C and the incidence of T2DM in a Chinese population. Methods We used logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the incidence of T2DM among 7,791 participants from the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION) cohort study at baseline. Results After adjusting for age, sex, body mass index, smoking status, alcohol intake, low-density lipoprotein cholesterol level, strenuous activity, education level, family histories of T2DM and tumors, and the presence of hypertension, tumor, stroke, and coronary heart disease, we showed that TG/HDL-C was positively associated with the incidence of T2DM at the 4-year follow-up (OR = 1.49, 95%CI = 1.26–1.78). TG/HDL-C and incidence of T2DM showed a nonlinear relationship; the inflection point of TG/HDL-C was 1.50. The ORs (95% CI) on the left and right sides of the inflection point were 2.50 (1.70–3.67) and 0.96 (0.67–1.37), respectively. After adjusting for age, sex, and body mass index (BMI) in the linear relationship, the OR of the incidence of T2DM was 1.60 (95%CI = 1.37–1.87). When the TG/HDL-C was less than 1.50 or greater than 1.76, the ORs (95% CI) were 2.41 (1.82–3.18) or 0.81 (0.53–1.25), respectively. Subgroup analysis showed no relationships of T2DM incidence with sex, BMI, family history of T2DM, or TG/HDL-C. Conclusion TG/HDL-C is positively associated with diabetes risk. In our study, with each increasing quintile, the risk of T2DM after 4 years was 1.60 or 1.49 depending on the variables adjusted. In addition, our cohort study showed a nonlinear relationship between TG/HDL-C and T2DM incidence, with an inflection point of 1.76 or 1.50, depending on the variables adjusted. When the TG/HDL was less than 1.50, the ORs (95% CI) were 2.41 (1.82–3.18) and 2.50 (1.70–3.67). When the TG/HDL-C was greater than 1.76 or 1.50, there was no significant difference in the change in OR.
Electrical Stimulation Promotes Stem Cell Neural Differentiation in Tissue Engineering

Nerve injuries and neurodegenerative disorders remain serious challenges, owing to the poor treatment outcomes of in situ neural stem cell regeneration. The most promising treatment for such injuries and disorders is stem cell-based therapies, but there remain obstacles in controlling the differentiation of stem cells into fully functional neuronal cells. Various biochemical and physical approaches have been explored to improve stem cell-based neural tissue engineering, among which electrical stimulation has been validated as a promising one both in vitro and in vivo. Here, we summarize the most basic waveforms of electrical stimulation and the conductive materials used for the fabrication of electroactive substrates or scaffolds in neural tissue engineering. Various intensities and patterns of electrical current result in different biological effects, such as enhancing the proliferation, migration, and differentiation of stem cells into neural cells. Moreover, conductive materials can be used in delivering electrical stimulation to manipulate the migration and differentiation of stem cells and the outgrowth of neurites on two- and three-dimensional scaffolds. Finally, we also discuss the possible mechanisms in enhancing stem cell neural differentiation using electrical stimulation. We believe that stem cell-based therapies using biocompatible conductive scaffolds under electrical stimulation and biochemical induction are promising for neural regeneration.
Metal Contents of Lake Fish in Area Close to Disposal of Industrial Waste

This research was conducted to analyze the content of Fe, Cu, Cd, Cr, and Pb in several species of fish taken from three lakes that are close to the disposal of industrial waste in Indonesia. The fish samples were taken from three lakes, namely, Muara Angke, Weda, and Morowali. The samples from Morowali were analyzed in April 2019, those from Weda from November to December 2019, and those from Muara Angke in June 2018. All the samples were then analyzed at the Chemistry Laboratory of the Department of Chemistry, Faculty of Mathematics and Natural Science, University of Indonesia, and the Integrated Laboratory of IPB. The main results showed that all types of fish from Morowali and Weda were no longer safe to consume because they contained Fe, Cu, Cd, and Cr exceeding the threshold of metal contamination. Meanwhile, all types of fish from Muara Angke, except for ayam-ayam, are still safe for consumption. The results of this study can be a source of information regarding metal content in fish and fish feed for safe consumption. Given the high consumption rate of fish and the hazards of heavy metals on humans' health, such research must be furthered.
The complete mitochondrial genome of the vulnerable Australian crest-tailed mulgara (Dasycercus cristicauda)

Abstract In this announcement, we report the complete mitogenome of the vulnerable Crest-tailed Mulgara (Dasycercus cristicauda) (Krefft, 1867). The mitogenome was 17,085 bp in length and contained 13 protein-coding genes, two rRNA genes, 22 tRNAs and a 1583 bp variable control region (D-loop). The features of the D. cristicauda mitogenome are consistent with other vertebrate mitogenomes but, in contrast to other marsupials, appears to contain a functional tRNA-Lysine with a UUU anticodon. Phylogenetic analysis of available entire mitogenomes reveals it forms a cluster with other marsupials in the Dasyuromorphia order within the Australidelphian clade, being most closely related to the Northern Quoll and the Tasmanian Devil.
Characterization of the complete chloroplast genome of a hybrid species Cymbidium tracyanum var ‘huanghua’ × Cymbidium faberi cv ‘huanghui’

Abstract Cymbidium tracyanumvar ‘huanghua’ × Cymbidium fabericv ‘huanghui’ is a hybrid species with important ornamental value. In the research, Illumina high-throughput sequencing technologies was used to sequence the chloroplastic genome of Cymbidium tracyanumvar ‘huanghua’ × C. fabericv ‘huanghui’. The genome features of Cymbidium tracyanumvar ‘huanghua’ × C. fabericv ‘huanghui’ and the phylogenetic relationships were reported and established. The total length of the complete chloroplast genome is 154,741 bp, consisting of a pair of inverse duplication regions 26,968 bp, a large single-copy region 84,410 bp and a small single-copy region 16,395 bp. The complete genome contains 73 protein-coding genes (PCGs), The entire genome contains 73 genes that encode proteins, 30 tRNA genes and 4 rRNA genes. The phylogenetic tree revealed that Cymbidium tracyanumvar ‘huanghua’ × C. fabericv ‘huanghui’ is more closely related to Cymbidium erythraeum.
Does 0.05 Tesla magnetic field have any effect on growth and blood glucose level

BALB/C دندش ميسقت هورگ ود هب . رگ تدم هب نومزآ هو ۱۰ تدم هب لقادح هنازور و زور ۱۰ يسيطانغم ناديم رد تعاس يسيطانغم ياقلا اب تخاونكي تباث ۰۵ / ۰ تفرگ يم رارق ،دوب هدش داجيا يمياد يابر نهآ طسوت هك لاست . رد دهاش هورگ تشاد رارق ناديم نودب يلو هباشم طيارش . هورگ ود ۱۰ و شيامزآ لوط رد ،لبق زور ۱۰ ور رظن تحت شيامزآ زا سپ ز دندش يم نزو هنازور و دندوب . يارب ًاددجم نومزآ هورگ سپس ۱۵ زا مهدزناپ زور رد و تفرگ رارق يسيطانغم ناديم رد زور دش هتفرگ نوخ دنق يريگ هزادنا تهج نوخ ةنومن ،ندرك ينابرق شور هب هورگ ود . اه هتفاي : نومزآ هورگ يارب يريگ نزو ۰۳ / ۰ ± ۳ / ۰ د مرگ زور ر ) رايعم ياطخ ± طسوتم ( دهاش هورگ يارب و ۰۳ / ۰ ± ۲۵ / ۰ توافت يرامآ رظن زا هك دوب زور رد مرگ راد ينعم ي تشادن . نومزآ هورگ يارب نوخ دنق حطس mg/dl ۱۸ / ۸ ± ۳۶ / ۱۱۴ دهاش هورگ يارب و mg/dl ۶۴ / ۴ ± ۸۱ / ۱۱۳ دادن ناشن راد ينعم توافت هك دوب . يريگ هجيتن : هدش رشتنم تلااقم رد ناديم رد نوخ دنق شيازفا ۰۱ / ۰ و ۰۰۱ / ۰ و لاست ناديم رد نزو شهاك ۹ / ۰ تسا هدش شرازگ يكيرتكلا يابر نهآ اب لاست . تخاونكي تباث يسيطانغم ناديم رضاح ةعلاطم رد ۰۵ / ۰ شوم نوخ دنق و دشر يور رب لاست BALB/C تسا ناديم نيا ندوب ررض يب رگناشن هك دوب رثا يب . هك دراد لامتحا ت دشاب يكيرتكلا يابر نهآ يترارح و يتوص تلالاتخا زا يشان هدش رشتنم تلااقم رد هدش شرازگ تارييغ .
Characterization of the complete mitochondrial genome of the Qiaoke sheep (Ovis aries)

Abstract Qiaoke sheep (Ovis aries) is a local sheep breed in Gansu province, China. It is a kind of Tibetan sheep that used for both meat and wool after long-term breeding. In this paper, the complete mitochondrial genome of Qiaoke sheep was sequenced. The total length of the mitochondrial genome is 16616 bp, and the base composition is 33.65% A, 13.14% G, 25.88% C and 27.33% T. The genome has a total of 37 genes, including 13 protein-coding genes, 22 tRNA genes, two ribosomal RNA genes and a control region (D-loop region). This complete sequence would enlarge useful genomic information for further studies.
Complete plastome sequence of Balakata baccata (Roxb.) Esser (Euphorbiaceae)

Abstract Balakata baccata belongs to the family Euphorbiaceae and is distributed in Yunnan province, China, and other southeast Asian countries, e.g., Bangladesh, Cambodia, India, Indonesia, etc. Here, we report and characterize the complete plastome of B. baccata. The complete plastome is 163,988 bp in length and contains a typical quadripartite structure and gene content found in angiosperms, including two inverted repeat (IR) regions of 27,274 bp, a large single-copy (LSC) region of 90,946 bp and a small single-copy (SSC) region of 18,494 bp. The plastome contains 129 genes, consisting of 84 protein-coding genes, 37 tRNA genes, and eight rRNA genes. The overall G/C content in the plastome of B. baccata is 35.6%. Phylogenetic results show that B. baccata is the earliest diverging lineage of Euphorbioideae. Euphorbia helioscopia + E. esula, E. tirucalli + E. milii and B. baccata have a closer phylogenetic relationship than other taxa within Euphorbiaceae. The complete plastome sequence of B. baccata will provide a useful resource for the conservation genetics of this species as well as for phylogenetic studies in Euphorbiaceae.
Enhanced Segmentation of Inflamed ROI to Improve the Accuracy of Identifying Benign and Malignant Cases in Breast Thermogram

Effective analysis of breast thermography needs an accurate segmentation of the inflamed region in Infrared Breast Thermal Images (IBTI) which helps in the diagnosis of breast cancer. However, IBTI suffers from intensity inhomogeneity, overlapping regions of interest, poor contrast, and low signal-to-noise ratio (SNR) due to the imperfect image acquisition process. To mitigate this, this work proposes an enhanced segmentation of the inflamed Region of Interest (ROI) using an active contour method driven by the multiscale local and global fitted image (MLGFI) model. The first phase proposes a bilateral histogram difference-based thresholding (BHDT) method for locating the inflamed ROI. This is then used for automatic initialization of active contours driven by MLGFI to segment the inflamed ROI from IBTI effectively. To prove the effectiveness of this segmentation method, its performance is compared with ground truth image and its accuracy is also evaluated with the state-of-the-art methods (Fuzzy C Means (FCM), Chan-Vese (CV-ACM), and K-means). From the analysis, it is found that the proposed method not only increases the precision and the segmentation accuracy but also reduces the oversegmentation and undersegmentation rate significantly. In the second phase, area-based feature (AF) and average intensity-based feature (AIF) along with the GLCM (gray level cooccurrence matrix) based second-order statistical features are extracted from the inflamed ROI. Based on these features, a system is developed to effectively classify the benign and malignant breast conditions. From the results, it is observed that the proposed model exhibits an improved accuracy of 91.5%, sensitivity of 91%, and specificity of 92% compared to the whole breast thermogram. Hence, it is concluded that the proposed method will improve the efficacy of thermal imaging in the diagnosis of breast cancer.
The complete mitochondrial genome sequences of Brassica napus varieties NY18 and 088018

Abstract Brassica napus variety NY18 and 088018 are female and male parents of the national registered variety Ningza 1818, respectively. Here, we determined the complete mitochondrial genomes of these two varieties. The genome sizes of NY18 and 088018 were 221,864 bp and 222,015 bp, respectively. Both genomes contained 40 protein-coding genes, 21 tRNA genes, and three rRNA genes. Considerable structural variations existed between the two mitochondrial genomes, which were separated into five syntenic regions. Phylogenetic analysis using the maximum-likelihood method showed that the mitochondrial sequences of B. napus were closely clustered, forming a single clade which had a relatively close relationship with the clade formed by B. rapa, B. juncea, and B. oleracea.
Journal of Psychological and

The lower moral emotions i.e. shame and guilt proneness has been linked by Cohen, Wolf, Panter, and Insko (2011) with a higher tendency of doing corruption. This present study hypothesized that meaningful work and perceived unethicality of no harm no foul behavior (NHNF) can predict the proneness in positive directions. Simple linear regression analyses on data from 210 employees (122 males, 88 females; Mage=27.96 years old; SDage=5.265 years) in the Greater Area of Jakarta, Indonesia showed that meaningful work, but not NHNF unethicality perception, can predict most of moral emotions proneness. This study provides empirical evidence against speculative claims that meaning, both in the general and work life, contributes to human morality. Corruption can be minimized by improving work meaning. The underlying assumption is that both meaning and morality make up “a good life”. This article uses an explanation of the work spirituality inspired by religious teachings which indeed greatly influence the psychological reality of Eastern society, like Indonesian. This study provides optimism for the prevention of unethical behaviors since meaning is an entity that can be constructed and intervened. We need a serious commitment to have appropriate cultural strategies for developing favored meaning.
Log, Stock and Two Simple Lotteries: Technical Supplement

These supplemental materials include technical details on the algorithm for decision-making under risk utilized in the main paper, as well as a concise review of neural foundations underlying the main paper's theoretical framework. Several peripheral extensions to the main work are also placed here.You may find the paper "Log, Stock and Two Simple Lotteries" at: http://ssrn.com/abstract=2763959.