Miracle-dz/UniFAR-FTUs huggingface dataset:
Modeling, Assessment, and Design of Porous Cells Based on Schwartz Primitive Surface for Bone Scaffolds

The design of bone scaffolds for tissue regeneration is a topic of great interest, which involves different issues related to geometry of architectures, mechanical behavior, and biological requirements, whose optimal combination determines the success of an implant. Additive manufacturing (AM) has widened the capability to produce structures with complex geometries, which should potentially satisfy the different requirements. These architectures can be obtained by means of refined methods and have to be assessed in terms of geometrical and mechanical properties. In this paper a triply periodic minimal surface (TPMS), the Schwarz's Primitive surface (P-surface), has been considered as scaffold unit cell and conveniently parameterized in order to investigate the effect of modulation of analytical parameters on the P-cell geometry and on its properties. Several are the cell properties, which can affect the scaffold performance. Due to the important biofunctional role that the surface curvature plays in mechanisms of cellular proliferation and differentiation, in this paper, in addition to properties considering the cell geometry in its whole (such as volume fraction or pore size), new properties were proposed. These properties involve, particularly, the evaluation of local geometrical-differential properties of the P-surface. The results of this P-cell comprehensive characterization are very useful for the design of customized bone scaffolds able to satisfy both biological and mechanical requirements. A numerical structural evaluation, by means of finite element method (FEM), was performed in order to assess the stiffness of solid P-cells as a function of the changes of the analytical parameters of outer surface and the thickness of cell. Finally, the relationship between stiffness and porosity has been analyzed, given the relevance that this property has for bone scaffolds design.
Data Mining and Visualization of Large Human Behavior Data Sets

This paper describes the deployment of a large-scale study designed to measure human interactions across a variety of communication channels, with high temporal resolution and spanning multiple years—the Copenhagen Networks Study. Specifically, we collect data on face-to-face interactions, telecommunication, social networks, location, and background information (personality, demographics, health, politics) for a densely connected population of 1 000 individuals, using state-of-the-art smartphones as social sensors. Here we provide an overview of the related work and describe the motivation and research agenda driving the study. Additionally, the paper details the data-types measured, and the technical infrastructure in terms of both backend and phone software, as well as an outline of the deployment procedures. We document the participant privacy procedures and their underlying principles. The paper is concluded with early results from data analysis, illustrating the importance of multi-channel high-resolution approach to data collection. Citation: Stopczynski A, Sekara V, Sapiezynski P, Cuttone A, Madsen MM, et al. (2014) Measuring Large-Scale Social Networks with High Resolution. PLoS ONE 9(4): e95978. doi:10.1371/journal.pone. 0095978 Editor: Yamir Moreno, University of Zaragoza, Spain Received February 15, 2014; Accepted April 2, 2014; Published April 25, 2014 Copyright: 2014 Stopczynski et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: The SensibleDTU project was made possible by a Young Investigator Grant from the Villum Foundation (High Resolution Networks, awarded to SL). Scaling the project up to 1 000 individuals in 2013 was made possible by a interdisciplinary UCPH 2016 grant, Social Fabric (PI David Dreyer Lassen, SL is co-PI) focusing mainly on the social and basic science elements of the project. This grant has funded purchase of the smartphones, as well as technical personnel. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist. * E-mail: arks@dtu.dk
Optimization and Research on Ellipse Fitting and Application Based on Algebraic Distance

Considering of the fact that sample points are easily affected by noise in a traditional ellipse fitting algorithm,the ellipse fitting approach of the least median square was proposed in this paper with the foundation of algebraic,geometric distance and RANSAC algorithm(random sample consensus). Linear transformation on the original data is adopted,and then many tests of selected different points from the painted pentagon are performed with the help of the minimum Euclidean distance between the fitting ellipse and boundary points.In the end,five parameters of the ellipse are obtained and the final ellipse is fitted.The experimental results on simulated and actual images show that the algorithm has good accuracy,robustness and small time complexity;in the meantime,it can correctly fit and recognize the planets.
PRICK AND SOAK Agroacterium tumefaciens-MEDIATED IN PLANTA TRANSFORMATION IN TOMATO (Lycopersicon esculentum Mill.)

One of the modern plant breedings through genetic engineering is Agrobacterium tumefaciens-mediated transformation. Agrobacterium tumefaciens-mediated transformation can be performed in vitro or in planta. In planta transformation arises from the weaknesses of the in vitro method such as need high hygiene standard, professional tissue culture experts, and more time to prepare explants and somaclonal variation. In planta transformation is a method to transfer the gene to the plant genome without any tissue culture stages. The aims of this research were to know the possibility of the prick and soak in planta method with the target of tomato seeds and to know the most suitable inoculation time for tomato seeds transformation by prick and soak method the transformation is done by pricking the seeds and soaking them in the A. tumefaciens suspension. The treatments in this study were 1 and 2 days inoculation time to test the efficacy of prick and soak in planta transformation method. Tomato seeds were pricked with a needle on the center once, and then soaked in A. tumefaciens strain LB4404 suspension carrying pKYS-SoSPS1 plasmid with Neomycin Phosphotransferase (NPTII) and Saccharum officinarum Sucrose Phosphate synthase (SoSPS1) genes. Visualization of tomato’s DNA samples after PCR showed that 1-day inoculation sample was positively integrated with NPTII gene and negative in the 2 days inoculation treatment.
Sport Specific Substrate Utilization During a Maximal Oxygen Consumption Test

RESULTS: A total of 189 concussions were reported, with most observed in girls (56%). Symptoms resolved within 7 days in 41% of reported concussions. Interestingly, we detected several symptom dependencies, such as higher odds of light sensitivity (OR= 20.71, 95% CI: 8.58, 50.00) with concurrent noise sensitivity, and higher odds of irritability (OR= 9.04, 95% CI: 3.74, 21.85) and drowsiness (OR= 7.46, 95% CI: 3.48, 15.98) with concurrent insomnia. We also observed lower odds of longer symptom resolution time in concussions due to player contact mechanisms than those due to non-player-contact mechanisms (Adj. OR= 0.33, 95% CI: 0.18, 0.59). CONCLUSIONS: Determinants of soccer-related concussions and their sequelae appear to be multifactorial. The observed symptom dependencies may encourage clinicians to evaluate players for specific symptoms in the presence of others while also indicating common neurological pathways affected by trauma in this context. Injury mechanism may also be associated with concussion outcomes, although future investigation is warranted.
Distribution of Clostridium Difficile Ribotypes in Macedonian Patients and their Antimicrobial Susceptibility

BACKGROUND: Clostridium difficile is a major nosocomial pathogen. In Europe, this bacterium is mostly characterised by PCR ribotyping. Most of the Clostridium difficile infections (CDI) are treated with vancomycin or metronidazole, although prolonged antibiotic use is considered as one of the main risk factors for CDI. AIM: This study aimed to detect the presence of various C. difficile ribotypes in hospitalised patients and to investigate their toxigenicity and antibiotic susceptibility. MATERIAL AND METHODS: All stool samples obtained from each patient were inoculated on Columbia blood agar and cycloserine cefoxitine fructose agar (CCFA) for isolation of C. difficile. Glutamate dehydrogenase and toxins A and B were investigated by immunochromatographic tests. Final confirmation of the isolates was performed by Vitek 2 and MALDI-TOF. A total of 21 isolates were collected for further investigation. PCR ribotyping was performed as described by Janezic and Rupnik. PCR ribotype profiles were analysed using software (Bionumerics, Applied Maths). Antibiotic susceptibility was determined by E-tests for metronidazole, vancomycin, tetracycline, clindamycin, erythromycin, imipenem, ciprofloxacin and moxifloxacin. RESULTS: About 48% of C. difficile isolates belonged to ribotype 001/072. So, this ribotype was the most common ribotype in this study. The remaining 52% of C. difficile isolates consisted of 10 different ribotypes: 017, SLO 160, SLO 187, SLO 120, 255/258, 014/020, 046, 002, 070 and 027. Furthermore, 20 (95.2 %) out of 21 isolates of C. difficile were toxigenic. Toxins A and B were detected simultaneously in 90.5 % of C. difficile isolates. Two isolates from the ribotype 017 were toxin B positive only. Treatments with any of the following antimicrobials: clindamycin, erythromycin, ciprofloxacin and moxifloxacin (as well as many other antibiotics), could be a risk factor for CDI due to the high resistance of the strains in this study. About 90% of the strains from the most common ribotype 001/072 have MICs for clindamycin and erythromycin > 256 µg/ml. CONCLUSION: All strains isolated are highly resistant to ciprofloxacin. All strains were susceptible to vancomycin (median MIC was 0.63 µg/ml) and metronidazole (median MIC was 0.084 µg/ml), so these two antimicrobials remain optimal treatment option for CDI.
Impact of Edentulism on the quality of life of elderly primary care users

INTRODUCTION: Edentulism is known as a chronic process of dental loss, which accumulated during life, causes greater consequences in elderly individuals, such as inefficiencies of masticatory, phonetic and aesthetic functions. Studies on edentulism in the elderly are justified in the observation of limitations of oral health policies and popular knowledge on the subject. OBJECTIVE: To evaluate the impact of lack of teeth on the quality of life of elderly users of basic care. MATERIALS AND METHODS: A cross - sectional study was carried out with 108 elderly users of primary care in the city of Caico, Rio Grande do Norte, Brazil, who had no teeth (partial edentulism) or all teeth (total edentulism). The data were collected through visits to the Basic Health Units, applying a structured questionnaire and the GOHAI (Geriatric Oral Health Assessment Index) instrument to verify the impact of the lack of teeth on the quality of life of the elderly. RESULTS: The majority of the elderly are female (60%) and have a low educational level (70.4%). Partial edentulism was prevalent in 64.9% of the sample, whose number of missing teeth is between 12 and 22 (60.1%). The lack of teeth had a negative impact on the quality of life of the elderly, obtaining a GOHAI of 29.32 points. The impacts on systemic health are observed with the prevalence of chronic diseases (59.2%) and high Body Mass Index (BMI) among the elderly interviewed (60%). CONCLUSIONS: The lack of teeth had a negative impact on the quality of life of the elderly interviewed.
The potential of a grounded theory approach to study teaching probability

An important part of teaching probability is teachers interacting with students about probability.Most of these interactions do not occur anywhere else but inside the classroom so that is where weshould research teacher knowledge for future development of teacher training and professionaldevelopment. To accomplish this I propose a research methodology founded on the theoreticalassumptions of symbolic interactionism combined with a grounded theory approach. The purposeof this paper is to outline such a research methodology that focuses on teaching as classroominteraction between teachers and students. The discussion aims to emphasize the possibilities bythis way of studying teachers’ knowledge for teaching probability and refine the methodologicalconstruct. Examples used are from lessons where two teachers work with unknown sample spacesand interact with students regarding chance, variation and the importance of sampling.
Application of Natural Language Processing Techniques to Enhance Web-Based Retrieval of Genealogical Data

These problems are present because most search engines, both general and genealogy-specific, use a keyword-based approach to Information Retrieval (IR). In keyword-based IR, a document is considered relevant for the query if any one of the search terms appears anywhere in the document; case (upper or lower) is generally ignored. The relevant documents might be ranked based on how many search terms appear, the frequency with which those search terms appear or in what part of the document those search terms appear (i.e. title vs. body), but in general this approach is poorly suited to genealogy searching, except in the rare cases where a surname is so unique that any document containing that term is highly relevant.
Challenges in emergency peripartum hysterectomy in initial phase of obstetrics practice: series of 9 cases

Emergency peripartum hysterectomy (EPH) is usually done to control bleeding of life threatening peripartum haemorrhage when all of all conservative measures fail. It is a technically demanding surgical procedure that carries high rate morbidity and mortality. From January 2016 to January 2019 data of all EPH done by our in different hospital of the city is collected. Total of 9 patients fulfil the definition of EPH. We tried with all sorts as bimanual uterine compression, administration of oxytocin or prostaglandins, uterine packing, compression sutures such as the B-Lynch brace suture before operation to controlled haemorrhage. On failure of the above mentioned measure we plan EPH. We took help of a surgeon in all of 9 cases. Bleeding is the greatest challenge in our series. Out of 9 patient 8 patient survived, one patient died of bleeding due to DIC. There is one urinary bladder injury and repaired intraoperatively. All patient has minor wound infection and that was managed with oral antibiotics and wound dressings. Postoperative average ICU stay was 3 days. Average PRBC transfusion is 4 units and two patient required FFP transfusion. In one patient we did subtotal hysterectomy and in rest all other patient we did total hysterectomy. With good team work EPH can be done with acceptable morbidity and mortality.
Depressive symptoms and suicidal ideation in people living with HIV/AIDS and their caregivers: a comparative study

Background: Worldwide estimate indicates that more than 40.3 million people are living with HIV/AIDS and out of these, eight million are young people in the age group of 14-24 years. India is reported to be the second largest population of HIV-infected persons. Aim: A cross-sectional study was planned to assess the level of depressive symptoms and suicidal ideation in people living with HIV/AIDS and their caregivers. Materials and methods: A group of 300 participants was assessed on the Hamilton Depression Rating Scale and Suicidal Ideation Questionnaire. Results: The data were analysed using descriptive and inferential statistics. Overall, the results showed that people with HIV negative, HIV positive, and AIDS (F=616.96, df=2,147, p<0.01) as well as their caregivers (F=1365.10, df=2,147, p<0.01) significantly differed on depressive symptoms. Similarly, there were significant variations in suicidal ideation in caregivers of people with HIV negative, positive, and AIDS. Conclusion: Findings of the study highlight the need to develop targeted prevention initiatives including education, and counselling to prevent suicidal ideation and depressive symptoms in these individuals and their caregivers.
The Guideline for Segmentation and Part Of Speech Tagging on Very Large Scale Corpus of Contemporary Chinese

The Institute of Computational Linguistics of Peking University is developing a very large scale contemporary Chinese corpus segmented and with many tags based on the owned resources,e.g.the Grammatical Knowledge base of Contemporary Chinese.There are about 40 tags in the tag set.It contains common Part Of Speech tags,special usage tags of verbs and adjectives,proper noun,placename of phrase type,organization name of phrase type and so on. The scale of the corpus is about 27 millions Chinese characters.The Institute of Computational Linguistics of PKU has completed the task of 14 millions characters and the processing quality is very high. It is necessary to work out a complete guideline of corpus processing to obtain high quality tagged corpus.This paper introduces the principles of making out the guideline and the experiences of carrying out the guideline.
Dynamics and Simulation of General Human and Humanoid Motion in Sports

This chapter relates biomechanics to robotics. The mathematical models are derived to cover the kinematics and dynamics of virtually any motion of a human or a humanoid robot. Benefits for humanoid robots are seen in fully dynamic control and a general simulator for the purpose of system designing and motion planning. Biomechanics in sports and medicine can use these as a tool for mathematical analysis of motion and disorders. Better results in sports and improved diagnostics are foreseen. This work is a step towards the biologically-inspired robot control needed for a diversity of tasks expected in humanoids, and robotic assistive devices helping people to overcome disabilities or augment their physical potentials. This text deals mainly with examples coming from sports in order to justify this aspect of research.
Expression of MHC class I, HLA-A and HLA-B identifies immune-activated breast tumors with favorable outcome

ABSTRACT Antigen recognition by MHC class I molecules is a key step for the initiation of the immune response. We hypothesized that expression of these molecules could be a marker of immune-activated breast cancers. Data from KM Plotter were extracted to develop an exploratory cohort. Information from Cancer Genome Atlas (TCGA) and METABRIC was used to create two validation cohorts. Raw data were re-processed and analyzed using plyr R and Bioconductor. We predicted epitope-HLA binding to MHC I molecules by using NetMHC 4.0. Cox proportional hazards regression was computed to correlate gene expression and survival outcome. There was a weak but positive correlation between mutational burden and the expression of most MHC class I molecules. In the exploratory cohort, expression of HLA-A and HLA-B was associated with favorable relapse-free survival (RFS) and overall survival (OS) in the basal-like subgroup. This was confirmed in the METABRIC and TCGA dataset. Expression of HLA-A and HLA-B was associated with biomarkers of T cell activation (GZMA, GZMB, and PRF1) and improved the predictive capacity of known immunologic signatures. Several neopeptides expressed in breast cancer were also identified including FUK, SNAPC3, GC, ANO8, DOT1L, HIST1H3F, MYBPH, STX2, FRMD6, CPSF1, or SMTN, among others. Expression of HLA A and B is associated with T cell activation and identifies immune activated, basal-like breast cancers with favorable prognosis. Antigen recognition markers should be incorporated into the assessment of the tumor immune state of basal-like breast patients.
The Effect of Intravenous Dexketoprofen and Tenoxicam on Propofol Injection Pain

Amac: Calismamizin amaci propofol enjeksiyon agrisinin onlenmesinde tenoksikam ve deksketoprofenin etkinligini arastirmaktir.Metod: Calismaya 20-60 yas arasi 150 hastanin dahil edilmesi planlandi. Hastalar randomize olarak 3 gruba ayrildi. Genel anestezi induksiyonu icin iv olarak propofol uygulanmasindan 2 dk once hastalara; Grup I’de 2 mL salin, Grup II’de 20 mg (2mL) tenoksikam, Grup III’te ise 50 mg (2mL) deksketoprofen uygulandi. Hesaplanan propofol dozunun 4’te 1’inin uygulanmasi sonrasi enjeksiyon agrisi 4 puanli verbal derecelendirme skalasi (VRS) ve numerik degerlendirme skalasi (NRS) ile degerlendirildi. Bulgular: Deksketoprofen grubu, calisma ilaci uygulamasi esnasinda hastalarin siddetli agri duymasi nedeniyle 18. hastada sonlandirildi. Toplam 118 hastanin verileri degerlendirildi. Propofol enjeksiyon agrisi sikligi salin grubunda %76, tenoksikam grubunda ise %38 idi ve fark istatistiksel olarak anlamliydi (p<0,01). NRS skorlari salin grubunda 3,1±2,2, tenoksikam grubunda 1,7±1,7 ve deksketoprofen grubunda 1,9±1,5 idi ve salin grubunda tenoksikam ve deksketoprofen grubu ile karsilastirildiginda istatistiksel olarak anlamli sekilde yuksekti (sirasiyla p<0,01 ve p<0,05). Sonuc: Calismamiz sonucunda 20 mg iv tenoxicam on tedavisinin, propofol enjeksiyon agrisini azaltmada etkili oldugunu tespit ettik.
Analysis of the Essential Oils of Chamaemelum fuscatum (Brot.) Vasc. from Spain as a Contribution to Reinforce Its Ethnobotanical Use

Chamaemelum fuscatum (Brot.) Vasc. is a south west Iberian chamomile that has been traditionally used as folk medicine in its natural distribution area but currently it is underestimated regarding its biological activities. For this reason, it is proposed in this paper to get insight into the scientific validation of the traditional knowledge of this plant with the aim of taking advantage of its anti-inflammatory, gastroprotective and antinociceptive activities, among others. To this aim, the chemical composition of the essential oil from the whole plant, the flowers and the green parts of this plant has been evaluated by gas chromatography–mass spectrometry (GC–MS). Plant materials were collected in Badajoz (Spain). A total of 61 components including monoterpenoids, sesquiterpenoids and aliphatic esters were identified. (E)-2-Methyl-2-butenyl methacrylate (27.57%–18.53%) and 2-methylallyl isobutyrate (9.79%–7.51%) were the most abundant compounds in the essential oils of flowers and of the whole plant, whereas α-curcumene, trans-pinocarveol, α-bergamotene and pinocarvone were the major terpenoids irrespective of the plant part considered. Certain compounds showing a relative high abundance as isobutyl methacrylate, isoamyl butyrate, α-bergamotene and pinocarvone were identified for the first time in this species. Finally, we have reviewed the bioactivity of several compounds to relate the ethnobotanical use of this plant in Spain with its volatile profile. This work is a preliminary contribution to reinforce the use to this Mediterranean endemic plant as a natural source of bioactives.