Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification and characterization of potential druggable targets among Essential Hypothetical Proteins of A. baumannii

Acinetobacter baumannii is a critical pathogen responsible for a wide range of infections. A. baumannii exhibits resistance to a variety of antibiotic classes, emphasizing that new therapeutic targets are urgently needed. In A. baumannii, ATCC 179778. Among 458 essential genes, 47 are uncharacterized and considered to be an essential hypothetical protein (EHPs). In this study, the functional characterization of EHPs was conducted utilizing variable computational tools. The physicochemical parameters, subcellular localization, domain identification, 3D structure, and virulence capabilities were predicted for the EHPs. According to our results, they were shown to be of a different functional category such as: transporters, enzymes, binding proteins, and virulence factors. Enzymes made up around 47% of the total and 17.6% were predicted as virulence factors. BLASTP analysis against human proteome was tested to identify proteins that is found exclusively in pathogen. The druggable property of the proteins was examined. Of 34, 27 essential pathogen-specific proteins could be considered as new pharmacological targets. In draggability analysis, one EHP turned out to be druggable while the others were novel. Our findings might assist in the innovation of new drugs for Acinetobacter baumannii infections.
Unsupervised domain adaptation based on deep adapted features alignment

Abstract. Due to the difficulty of acquiring labeled hyperspectral image (HSI), an unsupervised classification method known as deep adapted features alignment (DAFA) was proposed. First, deep adapted features from two domains are extracted by a convolutional deep adaptation network. Then, in order to align the distribution of two domains more accurately, the class-wise covariance and centroid alignment between deep adapted features from two domains are realized by matrix transformation and translation operation while maintaining the manifold structure of source features. Finally, source covariance and centroid aligned features and labels are used to train a base classifier, and target predictions are obtained by this classifier. Experiments conducted on several real HSI dataset pairs demonstrate the proposed DAFA method can effectively reduce distribution discrepancy between different HSIs and obtain good classification results.
The efficiency of a typical meteorological year and actual climatic data in the analysis of energy demand in buildings

A typical meteorological year (TMY) for Poland was developed in 2004, on the basis of climatic data collected from 1971 to 2000. Due to the observed tendency of global warming, the buildings’ energy performance obtained with the use of TMY may differ from the actual heating and cooling demand. This research compares energy demand calculated using TMY and climatic data collected from 2001 to 2012. Calculations were made by means of a simulation computer program, designed for dynamic analyses of buildings and installation systems. The analyses concerned typical living quarters in a multifamily residential building located in Warsaw. According to the results, TMY is useful for estimating the heating demand of existing buildings. Cooling demand calculated with the use of TMY was, however, up to 37% lower in comparison with the mean cooling demand for subsequent years. This may distort the energy needs and indoor environment conditions in summer, and create discomfort while using existing and new buildings. Practical application : The paper presents comparison between energy demand calculated with the use of typical meteorological year (TMY) based on the climatic data from the period of 1971 to 2000, and real climatic data from subsequent 12 years, 2001–2012. There is substantial difference in the results presenting cooling demand in buildings evaluated with the use of both datasets. Unless national energy certification procedures are updated, this may cause serious faults in building design, due to incorrect assessment of internal conditions in new and existing buildings, and higher than expected energy use in summer.
Exploring the life contexts of patrolling police officers in the European Union – A scoping review

Abstract Background Patrolling police officers engage in different mentally, socially, and physically challenging life contexts which may affect their life and health. The aim of this scoping review is twofold, to explore life contexts of patrolling officers in the European Union, and to investigate how their lives and health are affected by environmental characteristics within these contexts. Methods The scoping review followed Arksey and O’Malley’s methodology and included a critical appraisal. The environmental model within Kielhofner’s Model of Human Occupation was used in the thematic analysis. The review was reported following PRISMA-ScR. Results In the 16 included studies, two contexts (where environments interact with persons on different levels) were discovered: the global and the immediate context. No local contexts were found. Primarily, research on the social, and occupational environments, including qualities identified in these environments were found. However, some environmental characteristics within patrolling officers’ physical environments were also discovered. Discussion This review contributes to the emerging research area of police officers’ life contexts, by mapping contexts and environments affecting their life and health. However, to get a deeper understanding of how officers are affected by their environments, interviewing them regarding how their different contexts affect their everyday living, would be important.
Cisplatin and Nano-particle Formulations of Cisplatin for Cancer Therapy: A Review

Cisplatin (cis-(diammine)dichloridoplatinum(II)) is the first platinum-based compound approved by the United States Food and Drug Administration (FDA) (U.S.). This is a first-line chemotherapeutic treatment used alone or combined with other anticancer drugs to treat a broad spectrum of malignancies, with cisplatin-based nano-formulations currently in clinical studies. Cisplatin has several drawbacks, including low aqueous solubility, drug resistance, and toxicity, all of which can be addressed by encapsulating the drug in Nemours nanocarriers. The various nano-delivery technologies developed for Cisplatin are covered in vast literature from different electronic databases. This review focuses on comparative findings over the recent advancements, developments, innovations, and updated literature for various CDDP nano-carrier systems.
Empirical Investigation of the Academic Emotions of Gaokao Applicants during the COVID-19 Pandemic

This global lockdown of educational institutions by COVID-19 has caused overwhelming disruption in students’ learning and assessment, which has substantial effects on their academic emotions. This study applied a mixed methods approach to investigate how COVID-19 influences Gaokao applicants’ academic emotions in the Chinese context. The study found that Gaokao applicants during the COVID-19 pandemic had strong positive activating emotions, positive deactivating emotions, and negative activating emotions. The results showed that there were significant gender differences in academic emotions, and students’ physical exercise was also related. This study found that there was no correlation between the Gaokao applicants’ academic emotions and their parents’ occupations, parents’ academic qualifications, or types of exams. As COVID-19 continues to be a worldwide public challenge, this study has implications on how to alleviate negative academic emotions of students who will take high-risk tests under the pressure of the pandemic.
An Approach of Exergy Analysis of Human Physiological Response in the Outdoor Conditions during Blocklaying in Ogun State, Nigeria

This work was borne out due to the fact that little or no research has been done on the outdoor condition of Nigeria workers most especially the mason activities during blocklaying. Author AIM made substantial contribution researching into the potential energy which is the exergy needed to perform a physical job of blocklaying in outdoor environment. Author AIM equally developed a model which is a modification of Fanger (1970) which has been in existence over 40 years ago. The co-authors contributed by initiating the project research, verifying every step of the research and monitoring the field work in a view to collect a very accurate environmental and physiological response data. The coauthors also developed part of the draft, proof read the complete draft and issued an approval for the submission. This work was carried out between author AIM and co-authors. Author and co-authors read and approved the final manuscript.
An Energy-Efficient Framework for WBAN in Health Care Domain

This paper provides the deep detailed information related to the importance of link-aware energy-efficient communication between sensor nodes working in the health care domain. Today, in the modern field of science and technology, wireless sensor networks are playing a vital role in real-life applications including medicine, health care, and disaster management. WBAN applications nowadays are successfully used in medical health care. WBAN application is classified into two subtypes which include wearable WBAN and implantable WBAN. For this reason, the patient health condition can be monitored anywhere and at any time. Mostly, the researchers, in the health care domain, are using latest communication standards including 3G, WiMax, Bluetooth, and Zigbee standards. In this paper, we had proposed an energy-efficient framework (M-DSDV-RMCP routing protocol) for WBAN. The proposed framework is based on the DSDV routing protocol based on the RMCP routing protocol.
Testing the Determining Factors of Knowledge Sharing Behavior

In today’s information-based economy, knowledge is considered as a critical and effective resource for assisting businesses in establishing departmental synergies, accelerating innovation, providing value to customers, and increasing revenue through market growth. Knowledge sharing behavior is defined as individual behavior that pertains to the exchange of information, experience, ideas, and skills with other individuals or groups of people inside an organization in order to enhance the company’s sustainability. The purpose of this study is to analyze and obtain empirical evidence of the factors that influence knowledge sharing behavior, which consists of intention to share knowledge, knowledge sharing self-efficacy and enjoyment in helping others by 297 middle managers in a bank setting. This research is an explanatory research that focuses on the causal relationship among variables. The data were collected through a questionnaire survey and were then analyzed using Structural Equation Modeling (SEM) with the Analysis of Moment Structure (AMOS) program. The results of this study show that knowledge sharing self-efficacy and enjoyment in helping others have positive and significant effect on intention to share knowledge. Furthermore, knowledge sharing self-efficacy, enjoyment in helping others and intention to share knowledge have positive and significant effect on knowledge sharing behavior. The mediation role of intention to share knowledge is also proven to be significant.
Brownfield reuse of dredged New York Harbor sediment by cement-based solidification/stabilization

Newly effective federal regulations restrict the ocean disposal of sediments dredged from the harbors of New York and Newark. The New York Port Authority is faced with a critical situation: find land-based disposal/uses for 10`s of millions cubic yards of sediments or lose standing as a commercial port for ocean-going ships. One of the technologies now being employed to manage the sediments is portland cement-based solidification/stabilization (S/S) treatment. At least 4 million cubic yards of the sediments will undergo cement-based S/S treatment. This treatment will immobilize heavy metals, dioxin, PCBs and other organic contaminants in the sediment. The treatment changes the sediment from a environmental liability into a valuable structural fill. This structural fill is being used at two properties. The first property is an old municipal landfill in Port Newark, New Jersey. The treated sediments are being used as structural fill to cover about 20 acres of the landfill. This will allow planned redevelopment of the landfill property into a shopping mall. The second property called the Seaboard site, was the location of a coal gasification facility and later a wood preservation facility. This 160-acre property has been designated for brownfield redevelopment. Over 4 million cubic yards of treatedmore » sediments will eventually cover this site. Portland cement is the selected S/S binding reagent. Nearly 500,000 tons of cement will eventually be used to treat the sediments. Cement was selected for its ability to (a) change the peanut butter-like consistency of the sediments into a structural material and (b) to physically and chemically immobilize hazardous constituents in the sediment. « less
Role of Emergency Surgery for Fatal Complications of Gestational Trophoblastic Neoplasia: A Single-Center Experience

Purpose High-risk gestational trophoblastic neoplasia (GTN) can lead to fatal complications; however, few reports have assessed emergency surgery as a treatment option for such complications. Thus, this study aimed to analyze the clinical features and prognosis of patients with GTN who underwent emergency surgery. Patients and Methods Thirteen patients with high-risk or ultra-high-risk GTN who underwent emergency surgery for fatal complications in the First Affiliated Hospital of Zhejiang University, School of Medicine from 2013 to 2020 were analyzed, and their medical records were reviewed. The patients’ characteristics and treatment were evaluated with respect to outcomes. Results Thirteen patients with GTN who underwent 15 emergency surgical procedures were identified in our center. The mean International Federation of Gynecology and Obstetrics score of these patients was 14.8 (range, 11–19). Of the 13 patients, six underwent brain surgeries, such as tumor resection (n = 5) and conservative surgery (n = 1). All the patients received multi-agent chemotherapy after emergency surgery, and the mean time from emergency surgery to subsequent chemotherapy was 12.7 days. Of the 13 patients, 10 (77%) were cured and disease-free, with a follow-up period ranging from 3 months to 8 years. All the patients (n = 6) who underwent emergency brain surgery survived and achieved complete remission. Conclusion For patients with high-risk GTN with fatal complications, especially brain lesions, emergency surgery combined with subsequent chemotherapy may provide a favorable prognosis.
Psychophysiological Adaptation of International Students to Learning Abroad

The article describes the problems international students encounter during psychophysiological adaptation. As the modern higher education system is characterized by academic mobility, and international students from countries with quite different geoclimatic and cultural traditions have to undergo an adaptation period, the problem under study is topical. The study was conducted at Kharkiv National Medical University (Ukraine) in 2020/2021. The research involved 1st, 2nd and 3rd-year international students (from 50 countries). The peculiarities of international students’ psychophysiological states were assessed during the stages of initial adaptation, stable adaptation and final adaptation. This study aims to provide a comprehensive analysis of the factors of the natural and socio-pedagogical environment that affect the psychological adaptation process of international students. The present study provides new information on the acclimatization patterns of international students who study in Ukraine, as well as its functional significance on selected performance measures. General theoretical methods, research methods and methods of statistical data processing have been employed. The results reveal that the destabilizing factors that negatively affect international students’ adaptation process include frequent hypothermia, dietary changes, inadequate and irregular food intake, insufficient physical activity and excessive mental stress. Practical recommendations to decrease these negative factors are proposed.
How student perceptions about online learning difficulty influenced their satisfaction during Canada's Covid‐19 response

Abstract The COVID‐19 pandemic has posed a significant challenge to higher education and forced academic institutions across the globe to abruptly shift to remote teaching. Because of the emergent transition, higher education institutions continuously face difficulties in creating satisfactory online learning experiences that adhere to the new norms. This study investigates the transition to online learning during Covid‐19 to identify factors that influenced students' satisfaction with the online learning environment. Adopting a mixed‐method design, we find that students' experience with online learning can be negatively affected by information overload, and perceived technical skill requirements, and describe qualitative evidence that suggest a lack of social interactions, class format, and ambiguous communication also affected perceived learning. This study suggests that to digitalize higher education successfully, institutions need to redesign students' learning experience systematically and re‐evaluate traditional pedagogical approaches in the online context. Practitioner notes What is already known about this topic University transitions to online learning during the Covid‐19 pandemic were undertaken by faculty and students who had little online learning experience. The transition to online learning was often described as having a negative influence on students' learning experience and mental health. Varieties of cognitive load are known predictors of effective online learning experiences and satisfaction. What this paper adds Information overload and perceptions of technical abilities are demonstrated to predict students' difficulty and satisfaction with online learning. Students express negative attitudes towards factors that influence information overload, technical factors, and asynchronous course formats. Communication quantity was not found to be a significant factor in predicting either perceived difficulty or negative attitudes. Implications for practice and/or policy We identify ways that educators in higher education can improve their online offerings and implementations during future disruptions. We offer insights into student experience concerning online learning environments during an abrupt transition. We identify design factors that contribute to effective online delivery, educators in higher education can improve students' learning experiences during difficult periods and abrupt transitions to online learning.
Synoptic comparison between two cases of subtropical cyclones in the South coast of Brazil

Subtropical Cyclones are low-pressure systems that occur in tropical or subtropical latitudes and that have characteristics of both tropical cyclones and extratropical cyclones. The subtropical class also has a thermodynamic forcing near the surface resulting from heat and humidity flows from the warm ocean. The objective of this study is to make a comparison between two cases of subtropical cyclones that occurred on the south coast of Brazil during the end of spring and summer periods in the Southern Hemisphere. The chosen cases were SC Cari and SC Eçai, which occurred respectively from March 10th to 13th of 2015 and from December 3rd to 6th of 2016. This study was carried out through the analysis of meteorological fields employing the ERA5 reanalysis data along with GOES-13 satellite imagery. In spite of both systems occurring on a similar spatial domain, their different atmospheric characteristics have an important part in their origin, intensity and trajectory. Their trajectories were of interest because of their uncommonness, where Cari moved at first towards the continent presenting risks to the society and only later moving towards the ocean till its dissipation. And Eçai formed over the land as a thermal low that moved towards the ocean gaining strength as it found warm waters, finding a new and more favorable environment.
Factors affecting the using information and communication technologies (ICTs) by livestock farmers in the Eastern Cape province

Abstract Livestock farming is a significant part of agricultural production in sub-Saharan Africa and is contributing immensely to household welfare. Livestock farmers have been exposed to different ICTs stations in developing countries. Nevertheless, efforts have been made to use ICTs but involvement does not replicate how ICTs influence livestock farmers to access and use to enhance productivity and farm returns of farmers. It is therefore imperative to investigate factors affecting the use of ICTs by livestock farmers in the Eastern Cape Province. The study made use of multi-stage sampling in selecting 170 livestock farmers. Descriptive statistics and binary logistic regression were used as analytical tools. Livestock farmers were using ICTs to enhance their production and farm returns respectively. The commonly used ICTs were radio and television, mobile phones, and computers. The use of ICTs by farmers was effective as they contributed significantly to enhancing the productivity of livestock farmers. Socio-economic and institutional factors influence the use and adoption of ICTs by livestock farmers. Therefore, the study recommends introduction training programs tailored to build knowledge and use of ICTs in increasing farmers’ awareness as well as gaining knowledge. Government must subsidize farmers so that they can be able to purchase data and ICT tools.
Ecological niche modeling for reintroduction and conservation of Aristolochia cathcartii Hook.f. & Thomson (Aristolochiaceae), a threatened endemic plant in Assam, India

Aristolochia cathcartii Hook.f. & Thomson is a medicinal plant species native to Assam (India). Karbi people have traditionally used the plant to treat a variety of ailments. The population stock of this species has been rapidly depleting in its natural habitats due to over-utilization, habitat fragmentation, and other anthropogenic activities. Extensive field surveys were carried out to investigate the population status of A. cathcartii in various forest areas of Assam’s Karbi Anglong district. In 20 km of transects, a total of 36 quadrats were observed. A. cathcartii density, frequency of occurrence, and abundance were recorded to be 0.65, 17.8, and 3.81, respectively. Ecological niche modelling was used to identify suitable habitat for the reintroduction and conservation of this plant in Assam in order to prevent its extinction in the future. The maximum entropy distribution modelling algorithm was used to identify suitable areas and habitat for the species’ reintroduction and conservation. Primary data on the occurrence of A. cathcartii was gathered from the natural habitat of Karbi Anglong district, Assam, for modelling. The model identified various forest areas in northeastern India that have suitable climatic conditions for plant reinforcement.