Miracle-dz/UniFAR-FTUs huggingface dataset:
Considerations Regarding the Research for the Conservation of Heritage Textiles in Romania

Textiles are valuable elements that make up Romania’s cultural heritage, being unique through the production techniques, materials used and their significance for the Romanian population. Heritage textiles represent bridges between past and present, kept in collections from different types of buildings. Many of them are preserved and exposed in heritage buildings that are open for public viewing and do not benefit from internal microclimate monitoring systems. These things can have serious repercussions on the integrity and conservation status of these fragile materials. The chapter proposes to analyze the approaches used in different studies to evaluate the risks to which the historical textile collections from Romania are exposed, depending on the place and the way in which they are kept. All these approaches aim to determine the degree of conservation of the materials and their implications on the health of the people with whom they come into contact. Based on the methodology applied in the studies already published, examined in the first part of the chapter, in the second part, a case study was performed on a different sample of historical textiles from Romania. This comes to complete the sphere of knowledge in the field.
Potential Inhibitors Targeting RNA-Dependent RNA Polymerase Activity (NSP12) of SARS-CoV-2

A novel coronavirus (SARS-CoV-2) that is initially found to trigger human severe respiratory illness in Wuhan City of China in 2019, has killed 2,718 people in China by February 26, 2020, and which has been recognized as a public health emergency of international concern as well. And the virus has spread to more than 38 countries around the world. However, the drug has not yet been officially licensed or approved to treat SARS-Cov-2 infection. NSP12-NSP7-NSP8 complex of SARS-CoV-2, essential for viral replication and transcription, is generally regarded as a potential target to fight against the virus. According to the NSP12-NSP7-NSP8 complex (PDB ID: 6NUR) structure of SARS, two homologous models were established for virtual screening in the present study, namely NSP12-NSP7 interface model and NSP12-NSP8 interface model. Seven compounds (Saquinavir, Tipranavir, Lonafarnib, Tegobuvir, Olysio, Filibuvir, and Cepharanthine) were selected for binding free energy calculations based on virtual screening and docking scores. All seven compounds can combine well with NSP12-NSP7-NSP8 in the homologous model, providing drug candidates for the treatment and prevention of SARS-CoV-2.
Advantages and limitations of implant surgery with CAD/CAM surgical guides: A literature review

Background The purpose of this study is to review the available literature associated with implant surgery using computer-aided design/computer-aided manufacturing (CAD/CAM) surgical guides and discuss the advantages and disadvantages of this advanced technique. Material and Methods An electronic literature search was conducted in the PubMed database for the relevant information on implant placement with CAD/CAM surgical guides. This review was constructed following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Articles were limited to those published within the past 10 years and in the English language. Only clinical studies were included. Inclusion criteria were: studies including 10 implants or more and studies presenting angular deviations in degrees and linear deviations in millimeter. Observational studies, reviews, animal studies, in vitro studies, case reports, simulation studies were excluded. Nine articles were included for qualitative synthesis. Results The initial search detected 61 articles, and after screening abstracts, a total of 15 articles were selected for full-text review. After the full-text analysis of the 15 articles, six articles were excluded as they did not meet inclusion criteria for study design, study population, and implant placement with data presentation for angular and linear deviations. Ultimately, nine articles providing angular and linear deviations between planned and actual placed implants were used in this review. Common problems that may be encountered by clinicians were listed, and recommendations were made on how to avoid those problems. Conclusions It has been suggested that although unrealistic expectations are often associated with implant placement with CAD/CAM surgical guides, there is no impeccable accuracy in the clinic. This review demonstrated that the practitioners should be aware of the angular and linear deviations up to 5 ° and 2.3 mm. Therefore, inexperienced dentists should obtain adequate training and be familiar with the basic steps with CAD/CAM surgical guides to avoid complications. Key words:CAD/CAM, CBCT, implant, stereolithography, surgical guide.
Effect of incentive spirometry after cardiac surgery: protocol for a systematic review

Introduction: Patients receiving cardiac surgeries present high risk of developing postoperative complications. Incentive spirometry (IS) is used for the prevention and treatment of postoperative pulmonary complications in patients undergoing cardiac surgeries. Publications have suggested that IS is ineffective. In contrast, some studies have shown that when IS is adequately used, it may lead to beneficial outcomes. Objectives: To assess the effect of IS in patients undergoing cardiac surgeries. Methods/design: Systematic Reviews with randomised and quasi-randomised trials with adult patients undergoing cardiac surgeries, evaluating the effect of flow or volumeoriented IS. Outcome measures: postoperative pulmonary complications; adverse events; mortality; length of hospital stay; length of intensive care unit stay; reintubation rate; pulmonary function; antibiotic use; oxygenation; and respiratory muscle strength. Search: MEDLINE, EMBASE, CENTRAL, PEDro, CINAHL, LILACS, SCIELO, Allied, AMED, Scopus, Open Grey database, the World Health Organization International Clinical Trials Registry Platform (WHO ICTRP), ClinicalTrials.gov, clinicaltrialsregister.eu, and ReBec. Two authors will independently extract data. PEDro scale will be used to evaluate the methodological quality of the studies. Metaanalysis will be performed using the inverse variance method and the random effects model in RevMan 5.3. We will use the I statistic to estimate the amount of heterogeneity across studies in each meta-analysis. Ethics and dissemination: The approval of an ethical committee is not required. Only clinical trials that have complied with ethical guidelines and followed the Declaration of Helsinki, will be included in this systematic review. The findings of this study will help clarify uncertainties about the effects of incentive spirometry in the postoperative period of cardiac surgery and may be disseminated to clinicians, assisting in decision making and including the best evidence in the treatment of their patients. Discussion: This review will clarify the uncertainty over whether IS is a useful technique for patients undergoing cardiac surgeries. While good quality studies have shown IS is an effective prophylactic technique, other studies have suggested that there is no evidence to support IS utilization.
Efficient weighted probabilistic frequent itemset mining in uncertain databases

Uncertain data mining has attracted so much interest in many emerging applications over the past decade. An issue of particular interest is to discover the frequent itemsets in uncertain databases. As an item would not appear in a transaction of such database for certain, several probability models are presented to measure the frequency of an itemset, and the frequent itemset over probabilistic data generally has two different definitions: the expected support‐based frequent itemset and probabilistic frequent itemset. Meanwhile, it is noted that the frequency itself cannot identify useful or meaningful patterns in some scenarios. Other measures such as the importance of items should be also taken into account. To this end, some studies recently have been done on weighted (importance) frequent itemset mining in uncertain databases. However, they are only designed for the expected support‐based frequent itemset, and suffer from low efficiency due to generating too many frequent itemset candidates. To address this issue, we propose a novel weighted probabilistic frequent itemsets (w‐PFIs) algorithm. Moreover, we derive a probability model for the support of a w‐PFI candidate in our method and present three pruning techniques to narrow the search space and remove the unpromising candidates immediately. Extensive experiments have been conducted on both real and synthetic datasets, to evaluate the performance of our w‐PFI algorithm in terms of runtime, accuracy and scalability. Results show that our algorithm yields the best performance among the existing algorithms.
Infectious diseases in primates: behavior, ecology and evolution.

1. Questions, Terminology, and Underlying Principles 2. Diversity and Characteristics of Primate Parasites 3. Primate Socioecology and Disease Risk: Predictions and Rationale 4. Host-Parasite Dynamics and Epidemiological Principles 5. Host Defenses: The Immune System and Behavioral Counterstrategies 6. Infectious Disease and Primate Social Systems 7. Parasites and Primate Conservation 8. From Nonhuman Primates to Human Health and Evolution 9. Concluding Remarks and Future Directions
Simulating the spread of Hieracium lepidulum in heterogeneous landscapes

for a thesis submitted in partial fulfilment of the requirements for the Degree of Doctor of Philosophy. Simulating the spread of Hieracium lepidulum in heterogeneous landscapes by Steven R. Wangen The invasion of non-indigenous species represents a severe threat to the health of native communities world-wide. In order for us to be e↵ective and e cient at mitigating the economic and ecological impacts of these invasions, it is critical that we improve our understanding of how specific traits of the invader interact with characteristics of their new environment. Understanding these dynamics can help to improve the e cacy and economy with which we are able to apply control e↵orts. At the same time, we can examine if there are predictable patterns of spread which are produced from those interactions, and generalise those patterns to other invasions. In order to address these aspects of invasion, I developed a simulation model utilising a highly detailed and expansive data set which reflects the demography and dispersal of one particular species, Hieracium lepidulum, as it invades a mountainous area on the South Island of New Zealand. The scope and fidelity of this dataset is such that it permits me to develop models of the demography and dispersal of the species reflecting habitat-specific variation within the invaded area. These models are then combined using a customised simulation software to create a spatially and temporally explicit simulation of H. lepidulum spread. These simulations are applied across a range of hypothetical landscapes which are constructed to represent varying degrees of abstraction of the actual landscape; the simulations are applied at di↵erent scales, and the landscapes represent mixtures of the component habitats at varying degrees of complexity and spatial configurations. The outcomes of these simulations are then used to address a number of general questions intended to identify if there are some simplifying principles that can be used when evaluating invasive spread, and to examine how these results compare to currently postulated theories regarding the spread of invasions, and how their progression is influenced by context of the landscape.
Metabolic flux and nutrient uptake modeling of normal and apoptotic CHO cells

Abstract Applying metabolic flux analysis as the basis, a dynamic mathematical model was developed for describing the growth and metabolic behavior of CHO cells producing monoclonal antibodies (MAb) in batch culture. The viable cell population was assumed to consist of normal growing, normal non-growing and apoptotic cell subpopulations. A logistic cell growth model was derived that differentiates between actively dividing, resting, and apoptotic cells. The rate of apoptotic cell formation was assumed to have a second order dependence on the normal cell concentration. The proposed mathematical model for metabolites included distinct terms that reflected the metabolic rates of growing and non-growing cell populations. The results of the prediction were in good agreement with experimental data for different initial conditions.
The molluscan-dominated benthic assemblages of the estuarine and shallow marine Upper Burdigalian deposits of the Korneuburg Basin in Lower Austria

Ein detailliertes Profil uber eine Lange von 1,8 km wurde in der Nahe des Ortes Stetten (NO) aufgenommen. Es handelt sich dabei um benthische Ablagerungen des Karpatiums (Oberes Burdigal) aus einem astuaren Bereich des sudlichen Korneuburger Beckens in der Zentralen Paratethys. Zwei statistische Methoden zeigen eine deutliche Wechselfolge von intertidalen und flach-subtidalen Molluskenassoziationen und einen Umweltgradienten von intertidalen zu subtidalen Bedingungen. Diese Faunenzusammensetzung mit ihrer typischen Wechselfolge weist auf ein dynamisches, subtropisches Okosystem aus einem Palaoastuar des sudlichen Korneuburger Beckens hin.
Investigation on Organochlorine Pesticides Residues and Trace Metals in Melon (Colocynthis citrollus L.): A Survey

Several nations of the world are facing crisis level of acute food security and malnutrition which required urgent attention. Melon very rich in protein, oil, minerals, vitamins and good source of energy. As a result, the high contamination of melon with heavy metals and pesticide residues threatens human and ecosystem. Organochlorine Pesticides (OCPs) and trace metals were undertaken in melon obtained from five major towns in Nigeria. Analytical instruments were used to analyze the extracted OCPs from dichloromethane and digested melon samples, respectively. The overall metal content per site of the studied elements in the selected sites was determined and it was in the following decreasing order: Mokwa > Bida > Suleja > Borgu > Saki. The mean metal concentrations were in the following decreasing order: Pb > Zn > Ni > Co > Cd. With exceptions of locations where Ni and Pb were below detection limit, the concentrations of Pb, Cd and Ni in other locations were above WHO/FAO recommended limit. Concentrations of Zn and Co were below WHO/FAO limits. Out of 17 isomers of OCPs analyzed only five isomers were detected. The overall OCPs content per site of the studied elements in the selected sites was determined and it was in the decreasing order: Bida > Borgu > Saki > Suleja. OCP was not detected in melon samples obtained from Mokwa. With exception of endosulfan II, endrin aldehyde, heptachlor, DDE and λ –BHC were above their respective maximum residual limit. Environmental monitoring and education are highly recommended.
TEGDroid: Test Case Generation Approach for Android Apps Considering Context and GUI Events

The advancement in mobile technologies has led to the production of mobile devices (e.g. smartphone) with rich innovative features. This has enabled the development of mobile applications that offer users an advanced and extremely localized context-aware content. The recent dependence of people on mobile applications for various computational needs poses a significant concern on the quality of mobile applications. In order to build a high quality and more reliable applications, there is a need for effective testing techniques to test the applications. Most existing testing technique focuses on GUI events only without sufficient support for context events. This makes it difficult to identify other defects in the changes that can be inclined by context in which an application runs. This paper presents an approach named TEGDroid for generating test case for Android Apps considering both context and GUI Events. The GUI and context events are identified through the static analysis of bytecode, and the analysis of app’s permission from the XML file. An experiment was performed on real world mobile apps to evaluate TEGDroid. Our experimental results show that TEGDroid is effective in identifying context events and had 65%-91% coverage across the eight selected applications. To evaluate the fault detection capability of this approach, mutation testing was performed by introducing mutants to the applications. Results from the mutation analysis shows that 100% of the mutants were killed. This indicates that TEGDroid have the capability to detect faults in mobile apps.
Investigating the role of Epstein-Barr virus in the pathogenesis of NK and T cell lymphoproliferations

Epstein-Barr virus (EBV) is strongly associated with rare but aggressive lymphoproliferative diseases of NK and T cell origin. The finding of clonal and episomal forms of the virus in tumour cells from these clinically diverse diseases indicates involvement of EBV at an early stage of lymphomagenesis. However, many fundamental questions about EBV’s contribution to pathogenesis remain unanswered. In vivo analyses herein found that infection of tonsillar (but not peripheral blood) T cells occasionally occurred in primary and persistent infection, whilst infection of NK cells was a rare event. By contrast, a high EBV load was found in peripheral blood NK cells from 3 adult patients with EBV-associated haemophagocytic-lymphohistiocytosis, a disease previously associated with CD8+ T cell infection in children. Complementary studies examined EBV latent gene expression in EBV+ T/NK malignancies. Notwithstanding an apparent absence of latent membrane protein 2A and 2B (LMP2A/B), these tumour cells were recognised and killed by LMP2-specific cytotoxic T lymphocytes. This paradox was resolved by identifying a novel LMP2 mRNA, initiated from within the terminal repeat (TR) region of the viral genome and containing downstream epitope-encoding exons. Expression of LMP2-TR in T/NK cell lines and primary tissue implicates this truncated viral protein in T/NK lymphomagenesis.
Co‐immobilization and Colocalization of Multi‐Enzyme Systems for the Cell‐Free Biosynthesis of Aminoalcohols

The manufacturing of aminoalcohols is an appealing transformation for industrial biocatalysis due to their high value as building blocks in synthetic chemistry. By co‐immobilizing dehydrogenases, ω‐transaminases and oxidases on porous carriers, we fabricated and characterized a multi‐functional heterogeneous biocatalyst that was further applied to the cell‐free biosynthesis of amines and aminoalcohols from alcohols and diols, respectively. This immobilized cascade integrates both redox cofactor and amine donor recycling systems into the amino alcohol biosynthesis. Spatial co‐localization of the multi‐enzyme system significantly increases the cofactor recycling efficiency, the system productivity and the product conversion. Using this multi‐functional heterogeneous biocatalyst, we achieved 80 % conversion of alcohols into amines and accessed a palette of up to 5 aminoalcohols starting from their corresponding diols in one‐pot. The results herein presented contribute to understanding the effects of the confinement of co‐immobilized enzymes on the cascade processes.
The cross-over frequency between pulse and high-frequency components of near-fault forward-directivity ground motions

Due to the scarcity of near-fault records with forward-directivity effects, synthetic near-fault pulse-like ground motions through superimposing pulse models and high-frequency components are commonly used in the earthquake engineering. However, in existing studies, the cross-over frequency in generating high-frequency components is usually empirical and unclear. In this article, a hybrid decomposition and resynthesis method is developed to quantify the cross-over frequency, in which the wavelet decomposition and high-pass filter are, respectively, used to get the pulse and high-frequency components for near-fault records. Using the 30 near-fault pulse-like records, the distribution of cross-over frequencies is obtained. It is interestingly found that the cross-over frequency is inversely proportional to the pulse period.
Cumulative Influence of Summer Subsurface Soil Temperature on North America Surface Temperature in the CFSv2

Analyzing a long simulation and a set of seasonal reforecasts of the Climate Forecast System version 2 (CFSv2), this study demonstrates a large model cold bias in the deep soil layer (100–200 cm) over most of North America continent during summer due to weaker seasonal change in summer. The summer subsurface temperature (SUBT) cold bias influences the land surface temperature (LST) during the summer and subsequent seasons in different ways over different geographical regions in North America: West of the Rocky Mountains, the SUBT's effect on LST is largely overruled by the stronger upstream marine influence from the Pacific. Over the central Great Plains, however, it is a major cause for severe cold LST bias during summer in the model simulation and reforecasts. As a result, model underestimates sensible heat flux into the atmosphere but overestimates latent heat flux. The latter may contribute to an excessive summer rainfall in the region. Over the northeast region, the SUBT cold bias persists to August and September, which causes an additional surface cooling in the fall and helps to bring LST to the freezing point early. This sets up the stage for a prolonged snow‐albedo feedback. In particular, the model long simulation that passes through previous summer and fall demonstrates longer persistence of snow cover over the northeast region than reforecasts initialized in late winter and spring do. A cold bias of the water temperature in the North Atlantic seems also to play a role to prolong cold bias in the northeast region.
Impact of 3D-printing structure on the tribological properties of polymers

The purpose of this paper is to examine the impact of three-dimensional (3D)-printing process settings (particularly print orientation) on the tribological properties of different polymers. ,In this study, fused deposition modelling 3D-printing technology was used for fabricating the specimens. To evaluate the influence of print orientation, the test pieces were manufactured horizontally (X) and vertically (Z). The tribological properties of various printed polymers, which are polylactide acid, high tensile/high temperature-polylactide acid and polyethylene terephthalate-glycol have been studied. The tribological tests have been carried out under reciprocating sliding and dry condition. ,The results show that the presence of various orientations during the 3D-printing process makes a difference in the coefficient of friction and the wear depth values. Findings suggest that printing structure in the horizontal orientation (X) assists in reducing friction and wear. ,To date, there has been very limited research on the tribology of objects produced by 3D printing. This work was made as an attempt to pave the way for future research on the science of tribology of 3D-printed polymers.