Miracle-dz/UniFAR-FTUs huggingface dataset:
Engagement in a medium secure personality disorder service: a comparative study of psychological functioning and offending outcomes.

BACKGROUND Specialist treatment programmes for personality disordered offenders suffer from high rates of non-completion. This has important consequences for service providers and individual patients. METHOD Data from hospital records and the Offenders Index were compared for groups of treatment completers (n = 22) and non-completers (n = 59) discharged from a specialist treatment programme. RESULTS Twenty-seven percent of patients completed treatment, 37% were expelled for rule breaking and 35% disengaged early from treatment. Psychometric assessments of anger expression and anxiety showed no differences between the groups, however, treatment completers showed lower levels of impulsivity and psychopathy than either of the non-completer groups. Rates of post-discharge offending for grave and standard list offences were 56.8 and 10.8%, respectively. CONCLUSIONS Despite careful selection methods, a large proportion of personality-disordered patients admitted to specialist units failed to complete treatment. Psychometric assessments of anger expression, anxiety and impulsivity showed limited utility in differentiating treatment completers and non-completers. Sample size limitations in this naturalistic follow-up impacted on the interpretation of differences observed between the groups on the primary outcome measure of re-offending after discharge.
The gate-keeping role of surgeons with regard to endometrial cancers in Lynch syndrome

After the discovery of Lynch syndrome in the 1960s [1], its definition started from hereditary nonpolyposis colorectal cancer (HNPCC) specifically focusing affected organs. However, affected organs include nearly the whole body the endometrium, ovary, ureter, stomach, pancreas, biliary system, small bowel, brain, and skin. The past several decades have shifted our focus from organs to genes. In the case of Lynch syndrome, mismatch repair genes (MLH1, MSH2, MSH6, and PMS2) and EPCAM play a role. Before gene discovery, several screening methods including family history, immunohistochemistry (IHC), microsatellite instability (MSI) and other criteria (Amsterdam [2] and Bethesda [3]) were developed to diagnose Lynch syndrome efficiently; some of these tools remain popular despite the development of gene based diagnostic tools.
Fluorescence microscopy applied to the analysis of mitotic spindle dynamics

The mitotic spindle is a cellular structure that guides proper chromosome segregation to daughter cells, thus ensuring genomic stability during cell proliferation. The mitotic spindle is made of microtubules, polymers of alpha and beta tubulin, and it is highly dynamic during the cell cycle, indeed it is build de novo and it is destroyed at each cell division. The spindle form, position and function are tightly coordinated with other cell cycle events and with cell cycle progression. Recent advances in fluorescence microscopy are very useful to study several aspects of mitotic spindle cycle. In this chapter, we will describe the use of fluorescence microscopy and live cell imaging applied to the study of mitotic spindle dynamics in budding yeast, a unicellular eukaryotic organism. Despite the small size of yeast cells, their morphology, subcellular structures and protein localization can be successfully imaged using proper strategies.
Aara’– a system for mining the polarity of Saudi public opinion through e-newspaper comments

Aara’ is a system for mining opinion polarity through the pool of comments that readers write anonymously at the online edition of Saudi newspapers. We use a nave Bayes classifier with a revised n-gram approach to extract the public opinion polarity, which is expressed in Arabic, classifying it into four categories. For training we manually marked the comments as belonging to one of the categories. All the words in the documents of the training set were removed except those with explicit connotations. After the training the words designated as vocabulary were classified into one of the categories. Our system carries out polarity classification over informal colloquial Arabic that is unstructured and with a reasonable proportion of spelling errors. The result of testing our system showed a macro-averaged precision of 86.5%, while the macro-averaged F-score was 84.5%. The accuracy of the system is 82%.
Preparation and Physicochemical Characterization of Topical Niosomal Formulation of Minoxidil and Tretinoin

Skin is one of the most important tissue in the body which protects from other tissues and organs against fluid loss and foreign agents. Also it can play role as absorptive area for topical drug application [1]. Skin has several structural and functional layers included epidermis, derma and hypodermis in which derma contain the hair follicles in all part except palm, red parts of the lips, sole’s skin and parts of genital system [2]. Hair cycle has 3 phases included anagen, catagen and telogen. Anagen (growth phase) continued for 2-6years and 85% of hairs are in this step [3,4]. Catagen (transition phase) is the apoptotic step which duration of 1-2 weeks and 0-5% of hairs have this step [5]. Finally, 5-10% of hairs are in telogen step which continued for 3 months and is the rest step [6]. Matrix cells stop proliferating during catagen, and catagen-inducing factors stimulate apoptosis in the hair matrix cells [7].
Universal GFP reporter for the study of vascular development

Summary: We report the generation and characterization of transgenic mouse and zebrafish expressing green fluorescent protein (GFP) specifically in vascular endothelial cells in a relatively uniform fashion. These reporter lines exhibit fluorescent vessels in developing embryos and throughout adulthood, allowing visualization of the general vascular patterns with single cell resolution. Furthermore, we show the ability to purify endothelial cells from whole embryos and adult organs by a single step fluorescence activated cell sorting. We expect that these transgenic reporters will be useful tools for imaging vascular morphogenesis, global gene expression profile analysis of endothelial cells, and high throughput screening for vascular mutations. genesis 28:75–81, 2000. © 2000 Wiley‐Liss, Inc.
Failure to find the relationship between dispersal and spatial autocorrelation in species abundance

Spatial autocorrelation in species abundances indicates a lack of independence between sample locations and causes problems in distribution modelling. Knowing the cause of such spatial autocorrelation is vital for selecting the best suited modelling methods. Most autocorrelation in distributions is caused by autocorrelation in the underlying environmental conditions. The aim of the study was to determine whether dispersal could be responsible for additional spatial autocorrelation. I used data from 107 species of the North American Breeding Bird Survey covering the conterminous United States to investigate this question. As is the case for most species, no direct information on the dispersal activity of the study species was available. Therefore, I derived dispersal indices from three ecological theories: the deviation from an abundance-ccupancy relationship, the spatial exponent of Taylor’s power law, and density dependence. Spatial autocorrelation was captured in conditional autoregressive regression models (CAR) and measured with a standardized version of the regression coefficient ρ, the extent of the optimized neighbourhood, and the additional variance explained in CAR models over traditional regression models. No consistent association between these measures of autocorrelation and the indices for dispersal was found. Results indicated that the indirect ecological indices for dispersal carried too much noise and too little information for successful analysis. Future research on the effects of dispersal on autocorrelation need to be based on improved indirect indicators or direct, empirical dispersal information.
SAR in the mother and foetus for RF plane wave irradiation

This paper describes the finite-difference time-domain calculation of SAR from 20 MHz to 3 GHz in hybrid voxel-mathematical models of the pregnant female. Mathematical models of the developing foetus at 8-, 13-, 26- and 38-week gestation were converted into voxels and combined with the reference adult female model, NAOMI at a resolution of 2 mm. Whole-body averaged SAR in the mother is presented as well as the average over the foetus, over the foetal brain and in 10 g of the foetus. The electric field values required to produce the ICNIRP public exposure restriction of 2 W kg−1 when averaged over 10 g of the foetus were calculated. Comparison suggests that the ICNIRP public reference level is a conservative predictor of local SAR in the foetus.
Bidirectional DC-DC converter utilizing magnetic and capacitive power transfer — 97.1% Efficiency at 1.2-MHz switching

A high-performance DC-DC converter is presented to improve the efficiency and modularity of the vehicular power system. The converter is capable of bidirectional power transfer between the isolated voltage sources. GaN semiconductor switches in the converter turn on and off softly by utilizing the energy stored in the leakage inductance of a transformer. A quasi-resonant operation is also explained which is suitable for low-power condition. The switches turn on at the valley of the drain-source waveform to secure soft switching. A 180-W prototype hardware was fabricated with a 63 mm × 31 mm printed circuit board (PCB) and 200-V GaN FET devices. Peak efficiency was 97.1% at 24-V/155-W output voltage/power and 1.2-MHz switching frequency. Another prototype converter demonstrated the quasi-resonant operation at 25-V/46.8-W output and 914-kHz switching frequency.
crp genes of Shigella flexneri, Salmonella typhimurium, and Escherichia coli

The complete nucleotide sequences of the Salmonella typhimurium LT2 and Shigella flexneri 2B crp genes were determined and compared with those of the Escherichia coli K-12 crp gene. The Shigella flexneri gene was almost like the E. coli crp gene, with only four silent base pair changes. The S. typhimurium and E. coli crp genes presented a higher degree of divergence in their nucleotide sequence with 77 changes, but the corresponding amino acid sequences presented only one amino acid difference. The nucleotide sequences of the crp genes diverged to the same extent as in the other genes, trp, ompA, metJ, and araC, which are structural or regulatory genes. An analysis of the amino acid divergence, however, revealed that the catabolite gene activator protein, the crp gene product, is the most conserved protein observed so far. Comparison of codon usage in S. typhimurium and E. coli for all genes sequenced in both organisms showed that their patterns were similar. Comparison of the regulatory regions of the S. typhimurium and E. coli crp genes showed that the most conserved sequences were those known to be essential for the expression of E. coli crp.
The effect of whole-body vibration therapy on bone metabolism, motor function, and anthropometric parameters in women with postmenopausal osteoporosis

Abstract Purpose: To review the research literature on the effectiveness of whole-body vibration (WBV) therapy in women with postmenopausal osteoporosis. Methods: A systematic review was conducted by two independent reviewers. Mean differences (MDs), standardized mean differences (SMDs), and 95% confidence intervals (CIs) were calculated, and heterogeneity was assessed with the I2 test. The Cochrane risk of bias tool was used to assess the methodological quality of the selected studies. Results: Nine randomized controlled trials involving 625 patients met the inclusion criteria. No significant improvement was found in bone mineral density (BMD) (SMD = −0.06, 95%CI= −0.22–0.11, p = 0.50); bone turnover markers (MD = −0.25, 95%CI= −0.54–0.03, p = 0.08); anthropometric parameters, including muscle mass, fat mass, body mass index (BMI), and weight (SMD = 0.02, 95%CI= −0.16–0.21, p = 0.81); or maximal isotonic knee extensor strength (SMD = 0.16, 95%CI= −0.63–0.95, p = 0.69). However, maximal isometric knee extensor strength improved (SMD = 0.71, 95%CI = 0.34–1.08, p = 0.0002). Conclusions: WBV is beneficial for enhancing maximal isometric knee extensor strength, but it has no overall treatment effect on BMD, bone turnover markers, anthropometric parameters, or maximal isotonic knee extensor strength in women with postmenopausal osteoporosis. Implication of rehabilitation Osteoporosis is the leading underlying cause of fractures in postmenopausal women, whole body vibration (WBV) has received much attention as a potential intervention for the management of osteoporosis in recent years. Whole body vibration is beneficial for enhancing maximal isometric knee extensor strength in women with postmenopausal osteoporosis. Whole body vibration has no overall treatment effect on bone mineral density, bone turnover markers, anthropometric parameters and maximal isotonic knee extensor strength in women with postmenopausal osteoporosis.
A robust intelligent face recognition framework using GNP-based multi-agent system

Previously, a principal component analysis (PCA) based face recognition framework using Genetic Network Programming (GNP) and Fuzzy Data Mining (GNP-PCA) was proposed to improve both the accuracy and robustness of the conventional PCA-based face recognition algorithm in the complicated illumination database. However, it is still not robust enough in the noisy testing environments. Therefore, a GNP-based multi-agent system is constructed by GNP-PCA and multi-resolution analysis in this paper. In the proposed approach, the different scales of images in the training set are regarded as different environments and each GNP-PCA is performed as an agent in each environment. Recognition is eventually realized by evaluating the prediction scores for different classes. According to the experimental results, the proposed method has almost no accuracy loss in the Gaussian noisy testing environments compared with GNP-PCA.
A Neural Verb Lexicon Model with Source-side Syntactic Context for String-to-Tree Machine Translation

String-to-tree MT systems translate verbs without lexical or syntactic context on the source side and with limited target-side context. The lack of context is one reason why verb translation recall is as low as 45.5%. We propose a verb lexicon model trained with a feed-forward neural network that predicts the target verb conditioned on a wide source-side context. We show that a syntactic context extracted from the dependency parse of the source sentence improves the model’s accuracy by 1.5% over a baseline trained on a window context. When used as an extra feature for re-ranking the n-best list produced by the string-to-tree MT system, the verb lexicon model improves verb translation recall by more than 7%.
Rating the Magnitude of Life Stress *

Three hundred and seventy-three subjects were rated on a scale of 0–20 — the degree to which each of 61 life events was regarded as upsetting. Mean scores for the events ranked in a significant way from catastrophic events such as death of child or spouse at the top end of the scale to trivial or desirable events at the bottom. There was substantial agreement between different sociodemographic groups and acceptable overall individual variation. In a pilot study of validity, scores were examined for two classes of events — exits and entrances from the social field. A previous controlled study had indicated an excess of exits but not entrances preceding clinical depression. In keeping with this difference, scale scores for exits were found to be high and for entrances low with only minimal overlap. A small study using an alternative scaling concept of adjustment to life change suggested that the scale based on upsetting was more valid for depression.
Evaluation of the Relationship between Brain-Derived Neurotropic Factor Levels and the Stroop Interference Effect in Children with Attention-Deficit Hyperactivity Disorder.

INTRODUCTION Brain-derived neurotropic factor (BDNF) has been suggested to play a role in the pathogenesis of attention-deficit hyperactivity disorder (ADHD). In addition, impairment in executive functions has been reported in children with ADHD. This study investigated the presence of a relationship between Stroop test scores and BDNF levels in children with ADHD. METHODS The study was conducted in the Department of Child Psychiatry at Dicle University. The study included 49 children between 6 and 15 years of age (M/F: 42/7), who were diagnosed with ADHD according to DSM-IV, and who did not receive previous therapy. Similar in terms of age and gender to the ADHD group, 40 children were selected in the control group. The Kiddie Schedule for Affective Disorders and Schizophrenia, Present and Lifetime version was administered to all participants. Parents and teachers were administered Turgay DSM-IV-based Child and Adolescent Behavior Disorders Screening and Rating Scale to measure symptom severity in children with ADHD. Children with ADHD underwent the Stroop test. BDNF levels were evaluated in serum by ELISA. RESULTS The ADHD and control groups did not differ in terms of BDNF levels. BDNF levels did not differ between ADHD subtypes. There was also no relationship between the Stroop test interference scores and BDNF levels. CONCLUSION The findings of the present study are in line with those in studies that demonstrated no significant role of BDNF in the pathogenesis of ADHD.
Enough of RE Processes- Let's Do Practices

The world of software development is constantly changing and evolving. New ideas arise all the time and existing ideas go in and out of fashion. Software development processes find it very hard to keep up with this rapid rate of change, especially as they find themselves quickly going of fashion or becoming bloated as they bolt on more and more information. Teams find themselves struggling as they try to mix-andmatch practices from various sources into a coherent way-of-working or work out where to start their improvements.
Dexamethasone, the poor man’s drug: an alternative to methylprednisolone in optic neuritis

Aim: To assess the visual function outcome and response of intravenous dexamethasone in the treatment of optic neuritis in a tertiary health care centre. Materials and Methods: Study included 30 patients of acute optic neuritis presenting within eight days of onset and with visual acuity less than 20/60 in the affected eye. Patients received intravenous dexamethasone 100 mg in 250 ml of 5% dextrose over 1-2 hours daily, for three consecutive days[7] . Parameters tested were pupillary reactions, visual acuity, fundus ndings, color vision, contrast sensitivity and visual elds for all patients at presentation and follow-up over a period of 1 year and results compared with standard pattern of outcome already laid down by randomised controlled trials such as ONTT(Optic Neuritis Treatment Trial) which used intravenous methylprednisolone 250 mg/six-hourly for three days followed by oral prednisolone for 11 days for treatment of optic neuritis and proved its efcacy. Results: Improvement in visual acuity was statistically signicant for distance on day 3 ( P =0.000434 ) and for near vision on day 3 ( P = 0.000045); improvement in color vision was statistically signicant on day 3 ( P =0.000143) . Signicant improvement in RAPD,contrast sensitivity and visual elds were seen by 1 month (p<0.05). No serious side effects were observed. At one year, 78.12% (25 out of 32) eyes had visual acuity ≥ 20/40. Conclusion: Intravenous dexamethasone is a cost effective alternative to methylprednisolone treatment for optic neuritis.
Novel models for the extension pneumatic muscle actuator performances

This paper illustrates the design, implementation and modelling of the extensor pneumatic muscle actuator (PMA). The extensor soft actuator has a vital feature of ability to bend and extend, and that give it the flexibility to use in numerous applications. The extended behaviour of this actuator is modelled mathematically to be used to predict the length of a wide range of actuators at different air pressure amounts and make the position control of such type of actuator easier and precise. Moreover, the contraction force formula is modified to describe the pushing force for the extensor actuator. The bending behaviour of single muscle is explained and a 4-PMA continuum arm has been constructed to study its performance and model the bending angle.
Demonstration of a Selective Oversized Cavity in a Terahertz Second-Harmonic Gyrotron

A method of increasing the selectivity of highly-oversized open cavities is experimentally demonstrated in the electron cyclotron maser (gyrotron) operating at the second cyclotron harmonic in a high transverse mode (presumably, TE58,13) of a circular cylindrical cavity at a frequency near 1.2 THz in the magnetic field of 24 T. This method is purely electrodynamical and based on a simple deformation of the cavity wall. The proposed approach paves the way for increase of the gyrotron frequencies and for enhancing the selectivity of open cavities in other applications.
Effect of Long-term Transcranial Direct Current Stimulation on Glx and GABA: A Pilot Study

Previous studies have demonstrated that transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (dlPFC) can enhance working memory. However, the mechanism underlying the long-term tDCS is still unclear. This pilot study aims to examine neurotransmitters such as gamma-aminobutyric (GABA) and Glx (a measure of glutamate and glutamine combined) and working memory in response to the long-term anodal tDCS over dlPFC. Six healthy, right-handed young adults enrolled in this study received 2-mA anodal tDCS over dlPFC within 4 weeks. Long-term tDCS means that it was applied 5 times per week for the first two weeks and once for the last two weeks with 30 min each time. The other six participants were enrolled as the control group without stimulation for testing the baseline enhancement of working memory due to learning. The GABA and Glx levels were assessed by Magnetic Resonance Spectroscopy (MRS), while a 3-back task was performed to assess working memory. Data were collected at the beginning of the experiment, after two-week tDCS and at the end of the experiment. We found that the working memory was not significantly enhanced by the first two-week tDCS because the accuracy of response in 3-back was not significantly increased compared to the control group. Meanwhile, there were no significant changes in the levels of GABA. However, the Glx level was found significantly decreased in both 2- and 4-week MRS measurements. The observation that the long-term tDCS causes the decrease of excitatory neurotransmitters implies the different underlying mechanisms between the long-term tDCS and the single one.