Miracle-dz/UniFAR-FTUs huggingface dataset:
Internet of Things: An exploration study of opportunities and challenges

Internet of Things (IoT) has drawn great attention in industry, academia, and research As the IoT technology still in beginning of its implementation in all industries and so much research are ongoing to study and develop business model to grasp the opportunities brought by IoT. A research market conducted by Gartner expects that around 25 billion IoT devices or sensors to be connected by 2020. As expected IoT technology will enter every aspect of our life. Therefore, the main objective of this paper is to provide an exploration of how businesses will be affected by IoT introduction and listing the opportunities brought IoT technology and what challenges are facing its implementation.
Cell-Penetrating TAT-FOXO3 Fusion Proteins Induce Apoptotic Cell Death in Leukemic Cells

FOXO proteins are Akt-regulated transcription factors involved in the control of cell cycle, DNA repair, stress defense, apoptosis, and tumor suppression. We reported that plasmid-based overexpression of constitutively active FOXO3 in cells from chronic lymphocytic leukemia (CLL) reduced their survival, suggesting that increasing FOXO3 activity in hematologic malignancies may represent a promising therapeutic strategy. The transactivating transcription factor (TAT) protein transduction domain (PTD) derived from the HIV TAT protein was shown to efficiently deliver macromolecular cargo in various cell types. In this study, wild-type FOXO3 and FOXO3 mutated on Akt sites [FOXO3 T32A/S253A/S315A or TM (triple mutant)] were fused to the TAT-PTD. Using biochemical techniques, flow cytometry, and microscopy analysis, we found a rapid and dose-dependent cell penetration into leukemic cells of unlabeled and fluorescein isothiocyanate-labeled TAT-FOXO3 fusion proteins followed by their accumulation within nuclear and cytoplasmic compartments. Treatment with TAT-FOXO3 TM—but not wild-type TAT-FOXO3—proteins induced Jurkat and K562 leukemic cell death and affected cell viability of other hematologic malignancies including primary cells from CLL. Cell transduction with TAT-FOXO3 TM induced apoptotic cell death as shown by morphologic changes, Annexin V/7-AAD (7-amino-actinomycin D) staining, activation of effector caspases, and PARP cleavage, caspase blockade through the use of the inhibitor Z-VAD, and expression of Bim and p27KIP1. By contrast, TAT-FOXO3 TM blocked cell proliferation of primary T cells, without affecting their viability. Together, our data show that cell penetrating TAT-FOXO3 TM fusion proteins constitute novel potential therapeutic agents in the treatment of lymphoproliferative disorders and hematologic malignancies. Mol Cancer Ther; 10(1); 37–46. ©2011 AACR.
MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells

Type 1 diabetes (T1D) is an autoimmune disease leading to β-cell destruction. MicroRNAs (miRNAs) are small noncoding RNAs that control gene expression and organ formation. They participate in the pathogenesis of several autoimmune diseases, but the nature of miRNAs contributing to β-cell death in T1D and their target genes remain to be clarified. We performed an miRNA expression profile on human islet preparations exposed to the cytokines IL-1β plus IFN-γ. Confirmation of miRNA and target gene modification in human β-cells was performed by real-time quantitative PCR. Single-stranded miRNAs inhibitors were used to block selected endogenous miRNAs. Cell death was measured by Hoechst/propidium iodide staining and activation of caspase-3. Fifty-seven miRNAs were detected as modulated by cytokines. Three of them, namely miR-23a-3p, miR-23b-3p, and miR-149-5p, were downregulated by cytokines and selected for further studies. These miRNAs were found to regulate the expression of the proapoptotic Bcl-2 proteins DP5 and PUMA and consequent human β-cell apoptosis. These results identify a novel cross talk between a key family of miRNAs and proapoptotic Bcl-2 proteins in human pancreatic β-cells, broadening our understanding of cytokine-induced β-cell apoptosis in early T1D.
Towards reading trackers in the wild: detecting reading activities by EOG glasses and deep neural networks

Reading in real life occurs in a variety of settings. One may read while commuting to work, waiting in a queue or lying on the sofa relaxing. However, most of current activity recognition work focuses on reading in fully controlled experiments. This paper proposes reading detection algorithms that consider such natural readings. The key idea is to record a large amount of data including natural reading habits in real life (more than 980 hours from 7 participants) with commercial electrooculography (EOG) glasses and to use them for deep learning. Our proposed approaches classified controlled reading vs. not reading with 92.2% accuracy on a user-dependent training. However, the classification accuracy decreases to 73.8% on natural reading vs. not reading. The results indicate that there is a strong gap between controlled reading and natural reading, highlighting the need for more robust reading detection algorithms.
Respiratory effects of bioaerosols: exposure-response study among salmon-processing workers.

OBJECTIVES The aim of the study was to determine exposure-response relationships in salmon-processing workers. METHODS Cross-shift FEV1, acute respiratory symptoms, and exposure to total protein, parvalbumin and endotoxin were main variables measured during one workweek. Exposure-response relationships were analyzed by Generalized Estimation Equations of cross-week data and by multiple regressions of day-to-day data. RESULTS Exposure levels were higher in those workers who reported use of water hose. GEE showed negative coefficients for interaction between TP exposure and time (days) on cross-week change of FEV1. Multiple regressions showed significant associations between TP levels and cross-shift change of FEV1 and symptoms (cough, chest tightness) only for Monday shifts. CONCLUSIONS A tolerance effect during the course of a workweek is suggested. Use of water hose is a risk process with regard to the liberation of measured components of bioaerosols.
Joint Effects of PON1 Polymorphisms and Vegetable Intake on Ischemic Stroke: A Family-Based Case Control Study

Paraoxonase 1 gene (PON1) polymorphisms and dietary vegetable and fruit intake are both established determinants of ischemic stroke (IS). However, little is known about whether these factors jointly influence the risk of IS. We analyzed the main effects of PON1, as well as the interactions between PON1 and dietary vegetable or fruit intake with the risk of total IS and its subtypes in a family-based case-control study conducted among 2158 Chinese participants (1007 IS cases and 1151 IS-free controls) from 918 families. Conditional logistic regression models, with each family as a stratum, were used to examine the association between rs662 and IS. Gene-diet interactions were tested by including a cross-product term of dietary vegetable or fruit intake by rs662_G allele count in the models. Each copy of the PON1 rs662_G allele was associated with 28% higher risk of total IS (p = 0.008) and 32% higher risk of large artery atherosclerosis subtype (LAA) (p = 0.01). We observed an interaction between rs662 and vegetable intake for both total IS (p = 0.006) and LAA (p = 0.02) after adjustment for covariates. Individuals who carry the rs662_A allele may benefit to a greater extent from intake of vegetables and thus be more effectively protected from ischemic stroke, whereas carriers of the G allele may still remain at greater risk for ischemic stroke due to their genetic backgrounds even when they consume a high level of vegetables. More studies are needed to replicate our findings among other populations.
Power line network topology identification using admittance measurements and total least squares estimation

In this paper, we consider the identification of a smart grid network topology by means of admittance measurements performed at the network nodes. We show how the application of the transmission line theory allows the identification of the node-to-node connections. Thereby, a topology identification algorithm is presented. The identification error due to the network noise is reduced by performing repeated measurements, either at different time instants or over a set of frequencies, at each network node. The information is then fused by means of the total least square regression technique, which is also compared to a simpler estimator. A thorough analysis of the results is then presented, which shows good reliability of the proposed algorithm.
Does Tai Chi improve psychological well-being and quality of life in patients with cardiovascular disease and/or cardiovascular risk factors? A systematic review protocol

Introduction Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. Psychological risk factors such as stress, anxiety and depression are known to play a significant and independent role in the development and progression of CVD and its risk factors. Tai Chi has been reported to be potentially effective for health and well-being. It is of value to assess the effectiveness and safety of Tai Chi on psychological well-being and quality of life in people with CVD and/or cardiovascular risk factors. Methods and analysis We will include all relevant randomised controlled trials on Tai Chi for stress, anxiety, depression, psychological well-being and quality of life in people with CVD and cardiovascular risk factors. Literature searching will be conducted until 31 December 2016 from major English and Chinese databases. Two authors will conduct data selection and extraction independently. Quality assessment will be conducted using the risk of bias tool recommended by the Cochrane Collaboration. We will conduct data analysis using Cochrane’s RevMan software. Forest plots and summary of findings tables will illustrate the results from a meta-analysis if sufficient studies are identified. Ethics and dissemination Ethics approval is not required as this study will not involve patients. The results of this study will be submitted to a peer-reviewed journal for publication, to inform both clinical practice and further research on Tai Chi and CVDs. Discussion This review will summarise the evidence on Tai Chi for psychological well-being and quality of life in people with CVD and their risk factors. We anticipate that the results of this review would be useful for healthcare professionals and researchers on Tai Chi and CVDs. Trial registration number International Prospective Register for Systematic Reviews (PROSPERO) number CRD42016042905.
The clonal expansion of human T lymphotropic virus type 1-infected T cells: a comparison between seroconverters and long-term carriers.

BACKGROUND The clonal expansion of human T lymphotropic virus type 1 (HTLV-1)-infected T cells is considered to be important for the maintenance of infection. However, the process by which the clonality of HTLV-1-infected T cells is established is not understood. METHODS HTLV-1 clonality in 4 adult seroconverters was analyzed by inverse long polymerase chain reaction (PCR) followed by cloning of the PCR products and evaluation of restriction fragment-length polymorphism. The results were compared with those for 8 long-term HTLV-1 carriers. RESULTS The clonality of HTLV-1-infected T cells in the seroconverters arose stochastically and was variable 3-5 years after seroconversion. On the basis of the frequency with which clones of cells infected with unique HTLV-1 provirus integration sites appeared, it was clear that the seroconverters had a greater number of unique clones with fewer infected cells than did the long-term carriers. CONCLUSIONS The clonality of the HTLV-1-infected T cells in the adult seroconverters, who had been newly infected via HTLV-1-carrier spouses, was more heterogeneous and less stable than that of the HTLV-1-infected T cells in long-term carriers, who were more likely to have been infected during infancy. The mechanism for the selective maintenance of certain clones in asymptomatic HTLV-1 carriers likely plays a role in the initiation of leukemogenesis.
50 / 0 C 4 Acid Metabolism and Dark CO 2 Fixation in a Submersed Aquatic Macrophyte ( Hydrila verticillata ) '

The CO0 compensation point of the submersed aquatic macrophyte HydriAW vertkiclata varied from bigh (above 50 microlters per liter) to low (10 to 25 microliters per liter) values, depnding on the growth conditions. Plants from the lake in winter or after incubation in an 11 C/9-hour photoperlod had higb vahls, whereas summer plants or those incubated in a 27 C/14-hour photoperiod had Ow Values The plants With lOw CO, comensation points exhibited dark '4C0, fixation rates that were up to 30% of the light fixation rates. This fixtion reduced respiratory CO, loss, but did not result in a net uptake of CO, at night. Tbe low compensation point plants also showed diunal fluctuations in titratable acid, such as occur in Crassulacea acid metaboism plants. However, dark fixation and diurnal acid fluctuations were n le in Hydria plants with high CO, compensation points. Exposure of the low compensation point plants to 20 micromolar A4C02 resulted in 60% of the 14C being incorporated into maate and aspartte, with only 16% in sugar phospates. At a high CO level, the C4 acid label was decreased. A pulse.chase study indicated that the 14C in malate, but not aspartate, decreased after a long (270-second) chase period; thus, the C4 acid turnover was much slower than in C4 plants. Pho enolpyruvate carboxyhse activity was high (330 micromoles per millugam chlorophyll per hour), as compared to nlrbose bisphosphate carboxylase (20 to 25), in the plants with low compensation points. These plants also had a pyruvate, Pi dlinase activity in the leaves of 41 micromoles per milliram chrwophyU per hour, which suggests they are not C, plants. NADand NADP+-malate debydrogenase acthities were 6136 and 24.5 micromoles per chlorophyli per hour, respectively. Of the three decarboxylating enzymes assayed, the activities of NADand NADP+-malic enzyme were 104.2 and 23.7 micromoles per milligram chlorophyli per hour, while phospboenolpyruvate carboxykinase was only
Parallel Elastic Elements Improve Energy Efficiency on the STEPPR Bipedal Walking Robot

This paper describes how parallel elastic elements can be used to reduce energy consumption in the electric-motor-driven, fully actuated, Sandia Transmission-Efficient Prototype Promoting Research (STEPPR) bipedal walking robot without compromising or significantly limiting locomotive behaviors. A physically motivated approach is used to illustrate how selectively engaging springs for hip adduction and ankle flexion predict benefits for three different flat-ground walking gaits: human walking, human-like robot walking, and crouched robot walking. Based on locomotion data, springs are designed and substantial reductions in power consumption are demonstrated using a bench dynamometer. These lessons are then applied to STEPPR, a fully actuated bipedal robot designed to explore the impact of tailored joint mechanisms on walking efficiency. Featuring high-torque brushless DC motors, efficient low-ratio transmissions, and high-fidelity torque control, STEPPR provides the ability to incorporate novel joint-level mechanisms without dramatically altering high-level control. Unique parallel elastic designs are incorporated into STEPPR, and walking data show that hip adduction and ankle flexion springs significantly reduce the required actuator energy at those joints for several gaits. These results suggest that parallel joint springs offer a promising means of supporting quasi-static joint torques due to body mass during walking, relieving motors of the need to support these torques and substantially improving locomotive energy efficiency.
Electric vehicle drive selection related issues

Energy crisis's due to the depletion of fossil fuel and need of pollution free environment has leaded the world automobile technology to switch over to Electrical propulsion system into vehicles. For the consumer expected performance of electrical vehicles proper selection of suitable electric motor is the first and important criterion. So in this studies selection of appropriate motor for electrical vehicle has been discussed based on tractive efforts requirements of vehicle and delivered by motor. Three leading candidates of traction motors as Induction motor (IM), Permanent magnet synchronous motor (PMSM) and Switch reluctance motor (SRM) are compared for maximum speed, dynamic efficiency, material cost and fault reliability. Induction motors could be appropriate choice but still not satisfactory. Multiphase induction motor can be the better selection considering all the key factors. Other important issues related to electric vehicles like Electro Magnetic Compatibility, Thermal management and fault tolerance are discussed in brief.
Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development

The severe disorders associated with a loss or dysfunction of midbrain dopamine neurons (DNs) have intensified research aimed at deciphering developmental programs controlling midbrain development. The homeodomain proteins Lmx1a and Lmx1b are important for the specification of DNs during embryogenesis, but it is unclear to what degree they may mediate redundant or specific functions. Here, we provide evidence showing that DN progenitors in the ventral midbrain can be subdivided into molecularly distinct medial and lateral domains, and these subgroups show different sensitivity to the loss of Lmx1a and Lmx1b. Lmx1a is specifically required for converting non-neuronal floor-plate cells into neuronal DN progenitors, a process that involves the establishment of Notch signaling in ventral midline cells. On the other hand, lateral DN progenitors that do not appear to originate from the floor plate are selectively ablated in Lmx1b mutants. In addition, we also reveal an unanticipated role for Lmx1b in regulating Phox2a expression and the sequential specification of ocular motor neurons (OMNs) and red nucleus neurons (RNNs) from progenitors located lateral to DNs in the midbrain. Our data therefore establish that Lmx1b influences the differentiation of multiple neuronal subtypes in the ventral midbrain, whereas Lmx1a appears to be exclusively devoted to the differentiation of the DN lineage.
Diagnosis of bladder tumours in patients with macroscopic haematuria: A prospective comparison of split-bolus computed tomography urography, magnetic resonance urography and flexible cystoscopy

Abstract Objective. The aim of this study was to compare split-bolus computed tomography urography (CTU), magnetic resonance urography (MRU) and flexible cystoscopy in patients with macroscopic haematuria regarding the diagnosis of bladder tumours. Materials and methods. In this prospective study, 150 patients underwent CTU, MRU and flexible cystoscopy. Two uroradiologists individually reviewed the images without any clinical information, using a questionnaire. Patient records and pathology reports were also reviewed. Results. At flexible cystoscopy, MRU and CTU, 32, 19 and 15 bladder lesions were identified, respectively. Histopathology showed that 13 of the 29 biopsied lesions were transitional cell carcinomas. Compared with the histopathology, the sensitivity and specificity for detection of tumours by CTU and MRU were 61.5% and 94.9%, and 79.9% and 93.4%, respectively. False-positive detection of bladder tumours, compared with histopathology, was reported in seven CTUs and nine MRUs, whereas the number of false-negative findings was five for CTUs and three for MRUs. Conclusions. Split-bolus CTU or MRU cannot replace cystoscopy in cases of macroscopic haematuria. MRU has a higher sensitivity than split-bolus CTU, and is a potential alternative to flexible cystoscopy. Patients with a low risk of bladder cancer may forgo flexible cystoscopy if a bladder tumour is identified by either CTU or MRU, and proceed straight to transuretheral resection of the bladder.
On the Importance of Household Production in Collective Models: Evidence from U.S. Data

The present paper develops a theoretical model of labor supply with domestic production. It is shown that the structural components of the model can be identified without a distribution factor, thereby generalizing the initial results of Apps and Rees (1997) and Chiappori (1997). The theoretical model is then estimated using the ATUS data. The empirical results are compared to those obtained from a similar model without domestic production.
Streaming Algorithms from Precision Sampling

A technique introduced by Indyk and Woodruff [STOC 2005] has inspired several recent advances in data-stream algorithms. We show that a number of these results follow easily from the application of a single probabilistic method called Precision Sampling. Using this method, we obtain simple data-stream algorithms that maintain a randomized sketch of an input vector $x=(x_1,.x_n)$, which is useful for the following applications. 1) Estimating the $F_k$-moment of $x$, for $k>2$. 2) Estimating the $\ell_p$-norm of $x$, for $p\in[1,2]$, with small update time. 3) Estimating cascaded norms $\ell_p(\ell_q)$ for all $p,q>0$. 4) $\ell_1$ sampling, where the goal is to produce an element $i$ with probability (approximately) $|x_i|/\|x\|_1$. It extends to similarly defined $\ell_p$-sampling, for $p\in [1,2]$. For all these applications the algorithm is essentially the same: scale the vector x entry-wise by a well-chosen random vector, and run a heavy-hitter estimation algorithm on the resulting vector. Our sketch is a linear function of x, thereby allowing general updates to the vector x. Precision Sampling itself addresses the problem of estimating a sum $\sum_{i=1}^n a_i$ from weak estimates of each real $a_i\in[0,1]$. More precisely, the estimator first chooses a desired precision $u_i\in(0,1]$ for each $i\in[n]$, and then it receives an estimate of every $a_i$ within additive $u_i$. Its goal is to provide a good approximation to $\sum a_i$ while keeping a tab on the "approximation cost" $\sum_i (1/u_i)$. Here we refine previous work [Andoni, Krauthgamer, and Onak, FOCS 2010] which shows that as long as $\sum a_i=\Omega(1)$, a good multiplicative approximation can be achieved using total precision of only $O(n\log n)$.
Analysis of Residual Ion Dump (RID) of Diagnostic Neutral Beam (DNB) injector for ITER

Residual Ion Dump (RID) of the 100 kV negative hydrogen ion source based Diagnostic Neutral Beam (DNB) injector, utilizes electrostatic fields for the ion beam deflection. There are four channels formed by five panels of length 1000mm. Each panel consists of 10 actively cooled elements called Tube Elements (TEs) made up of CuCrZr alloy. All TEs are of 1.5 m length with cross-section of 20 mm × 100 mm with a central bore of 16 mm provided for the coolant passage. Water with an inlet temperature of 55 C is used as coolant. Total flow rate and inlet pressure provided for RID are 5 kg/s and 2 MPa respectively. RID is designed for two types of cycles viz; 8.6× 105 pulse trains of 3s ON/20s OFF and 1.29×107 modulations of 100ms ON/100ms OFF.