Miracle-dz/UniFAR-FTUs huggingface dataset:
Mechanisms of Resistance to Chemotherapy in Breast Cancer and Possible Targets in Drug Delivery Systems

Breast cancer (BC) is one of the most important cancers worldwide, and usually, chemotherapy can be used in an integrative approach. Usually, chemotherapy treatment is performed in association with surgery, radiation or hormone therapy, providing an increased outcome to patients. However, tumors can develop resistance to different drugs, progressing for a more aggressive phenotype. In this scenario, the use of nanocarriers could help to defeat tumor cell resistance, providing a new therapeutic perspective for patients. Thus, this systematic review aims to bring the molecular mechanisms involved in BC chemoresistance and extract from the previous literature information regarding the use of nanoparticles as potential treatment for chemoresistant breast cancer.
Retracted article: Tranilast attenuates neuropathic pain during type-2 diabetes by inhibiting hypoxia-induced pro-inflammatory cytokines in Zucker diabetic fatty rat model

Abstract We, the Editors and Publisher of the journalArchives of Physiology and Biochemistry, have retracted the following article: Wei Zhang, Jun Ma, Shan Wang, Tao Huang & Min Xia (2020) Tranilast attenuates neuropathic pain during type-2 diabetes by inhibiting hypoxia-induced pro-inflammatory cytokines in Zucker diabetic fatty rat model, Archives of Physiology and Biochemistry, DOI: 10.1080/13813455.2020. 1854309 Since publication, the authors informed the Publisher and Editor that the authors had not received ethics approval from the Institutional Animal Care and Use Committee (IACUC) at the time that their research was conducted. As the Editor and Publisher also have concerns about the integrity of the reported results which the authors have been unable to address, all parties have agreed to retract the article to ensure correction of the scholarly record. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as ‘Retracted’.
Comparison of training responses and performance adaptations in endurance-trained men and women performing high-intensity interval training

ABSTRACT The efficacy of high-intensity interval training (HIIT) to elicit physiological and performance adaptations in endurance athletes has been established in men and to a lesser extent in women. This study compared lactate threshold (LT2) and performance adaptations to HIIT between men and women. Nine male and eight female cyclists and triathletes completed trials to determine their LT2 and 40 km cycling performance before, and after 10 HIIT sessions. Each HIIT session consisted of 10 × 90 s at peak power output, separated by 60 s active recovery. Main effects showed that HIIT improved peak power output (p = 0.05; ES: 0.2); relative peak power output (W.kg−1; p = 0.04; ES: 0.3 and W.kg−0.32; p = 0.04; ES: 0.3); incremental time to fatigue (p = 0.01; ES: 0.4), time trial time (p < 0.001; ES: 0.7) and time trial power output (p < 0.001; ES: 0.7) equally in both sexes. Although LT2 power output explained 77% of the performance improvement in women, no variable explained the performance improvement in men, suggesting another mechanism(s) was involved. Although HIIT improved cycling performance in men and women, it might not be appropriate to evaluate the effectiveness of HIIT using the same variables for both sexes.
A splicing factor switch controls hematopoietic lineage specification of pluripotent stem cells

Alternative splicing (AS) leads to transcriptome diversity in eukaryotic cells and is one of the key regulators driving cellular differentiation. Although AS is of crucial importance for normal hematopoiesis and hematopoietic malignancies, its role in early hematopoietic development is still largely unknown. Here, by using high‐throughput transcriptomic analyses, we show that pervasive and dynamic AS takes place during hematopoietic development of human pluripotent stem cells (hPSCs). We identify a splicing factor switch that occurs during the differentiation of mesodermal cells to endothelial progenitor cells (EPCs). Perturbation of this switch selectively impairs the emergence of EPCs and hemogenic endothelial progenitor cells (HEPs). Mechanistically, an EPC‐induced alternative spliced isoform of NUMB dictates EPC specification by controlling NOTCH signaling. Furthermore, we demonstrate that the splicing factor SRSF2 regulates splicing of the EPC‐induced NUMB isoform, and the SRSF2‐NUMB‐NOTCH splicing axis regulates EPC generation. The identification of this splicing factor switch provides a new molecular mechanism to control cell fate and lineage specification.
Sexual segment of the kidney of the lizard, Eutropis carinata: A light microscopic and ultrastructural seasonal study

We studied seasonal variation of the secretory granules in the epithelial cells of the sexual segment of the kidney (SSK) during the annual sexual cycle in the lizard, Eutropis carinata using light and electron microscopy in correlation with measurements of androgen levels. During the breeding phase, the epithelium of the SSK consists of simple columnar cells with basal nuclei. The cytoplasm contains numerous eosinophilic secretory protein and carbohydrate granules, but lacks glycosaminoglycans. These secretory granules develop during the regenerative phase when the circulating testosterone level increase. During the breeding phase, when the circulating testosterone levels are high, three types of secretory granules can be differentiated in the cytoplasm based on size and opacity; electron translucent type I, electron dense type II, and biphasic type III granules. Type II granules are found at various stages of maturity and degeneration/utilization. All types of secretory granules are released through an apocrine process. Microvilli and tight junctions are prominent at the apical portion of the cell. The cytoplasm contains, Golgi complexes, an abundant network of rough endoplasmic reticulum, numerous tubular mitochondria, condensing, mucus filled and empty vacuoles. Intercellular canaliculi are narrow and indistinct during the regenerative and breeding phases, respectively. During the regressed phase, when the circulating testosterone levels are lowest, the cells are found regressed with wide intercellular canaliculi and devoid of secretory granules. Then the cytoplasm contains a few round mitochondria, Golgi and scanty endoplasmic reticulum.
Moderating Effect of Growth Mindset on the Relationship between Attitude toward Tourism and Meaning in Life

Background/Objectives: This study aims to measure the moderating effect of growth mindset on how attitude toward tourism affects meaning in life for working people who have high job stress and are tired of life, and to suggest a way to improve meaning in life. Methods/Statistical analysis: The subjects of the study were 284 employees, and a survey was used for data collection. SPSS Win. 21.0 and SPSS MACRO PROCESS were used for data analysis. Reliability analysis, descriptive statistics analysis, correlation analysis, and moderating effect analysis were performed. Findings: First, attitude toward tourism, meaning in life, and growth mindset showed statistically significant and positive correlation coefficients; attitude toward tourism and meaning in life showed the highest correlation coefficient. Second, the growth mindset did help to improve the relationship between attitude toward tourism and meaning in International Journal of Pure and Applied Mathematics Volume 120 No. 6 2018, 5523-5540 ISSN: 1314-3395 (on-line version) url: http://www.acadpubl. eu/hub/ Special Issue http://www.acadpubl. eu/hub/
N‐cadherin localization in taste buds of mouse circumvallate papillae

Taste buds, the receptor organs for taste, contain 50–100 taste bud cells. Although these cells undergo continuous turnover, the structural and functional integrity of taste buds is maintained. The molecular mechanisms by which synaptic connectivity between taste buds and afferent fibers is formed and maintained remain ambiguous. In the present study, we examined the localization of N‐cadherin in the taste buds of the mouse circumvallate papillae because N‐cadherin, one of the classical cadherins, is important for the formation and maintenance of synapses. At the light microscopic level, N‐cadherin was predominantly detected in type II cells and nerve fibers in the connective tissues in and around the vallate papillae. At the ultrastructural level, N‐cadherin immunoreactivity appears along the cell membrane and in the intracellular vesicles of type II cells. N‐cadherin immunoreactivity also is evident in the membranes of afferent terminals at the contact sites to N‐cadherin‐positive type II cells. At channel type synapses between type II cells and nerve fibers, N‐cadherin is present surrounding, but not within, the presumed neurotransmitter release zone, identified by large mitochondria apposed to the taste cells. The present results suggest that N‐cadherin is important for the formation or maintenance of type II cell afferent synapses in taste buds.
Selective adaptation in sentence comprehension: Evidence from event-related brain potentials

In this study, two event-related potential experiments were conducted to investigate whether readers adapt their expectations to morphosyntactically (Experiment 1) or semantically (Experiment 2) anomalous sentences when they are repeatedly exposed to them. To address this issue, we experimentally manipulated the probability of occurrence of grammatical sentences and syntactically and semantically anomalous sentences through experiments. For the low probability block, anomalous sentences were presented less frequently than grammatical sentences (with a ratio of 1 to 4), while they were presented as frequently as grammatical sentences in the equal probability block. Experiment 1 revealed a smaller P600 effect for morphosyntactic violations in the equal probability block than in the low probability block. Linear mixed-effects models were used to examine how the size of the P600 effect changed as the experiment went along. The results showed that the smaller P600 effect of the equal probability block resulted from an amplitude’s decline in morphosyntactically violated sentences over the course of the experiment, suggesting an adaptation to morphosyntactic violations. In Experiment 2, semantically anomalous sentences elicited a larger N400 effect than their semantically natural counterparts regardless of probability manipulation. Little evidence was found in favour of adaptation to semantic violations in that the processing cost associated with the N400 did not decrease over the course of the experiment. Therefore, a dynamic aspect of language-processing system was demonstrated in this study. We will discuss why the language-processing system shows a selective adaptation to morphosyntactic violations.
SOCIODEMOGRAPHIC VARIABLES VERSUS INTRINSIC AND EXTRINSIC MOTIVATION FOR ENGLISH LEARNING

409 HAKAN AYDOĞAN, AZAMAT AKBAROV ABSTRACT Intrinsic and extrinsic motivation are the two crucial factors for learning and using English language. In this study, we tried to examine associations between motivation for learning English and some sociodemographic variables. For that purpose, we conducted our research with 300 adolescents (192 females and 108 males). Their age ranged from 15 to 23 years. Our sample comprised both Turkish and Bosnian students, as well as high school and university students. We applied sociodemographic questionnaire as well as Intrinsic and extrinsic motivation for English learning scale (IEM-ELS). Our study yielded the following results: the distribution of participants' scores on intrinsic and extrinsic motivation subscales were left-skewed (the former distribution was more skewed than the latter one); the correlation between intrinsic and extrinsic motivation was small, positive, and significant; we did not find gender nor differences by nationality; age correlated positively with intrinsic but negatively with extrinsic motivation levels; and university students scored higher on Intrinsic motivation subscale and lower on Extrinsic motivation subscale, compared to high school students. The obtained results were discussed in the light of the previous studies in this branch of educational science.
Feed intake and feeding behavior traits for gestating sows recorded using electronic sow feeders

Abstract Electronic sow feeding (ESF) systems are used to control feed delivery to individual sows that are group-housed. Feeding levels for gestating sows are typically restricted to prevent excessive body weight gain. Any alteration of intake from the allocated feeding curve or unusual feeding behavior could indicate potential health issues. The objective of this study was to use data recorded by ESF to establish and characterize novel feed intake and feeding behavior traits and to estimate their heritabilities. Raw data were available from two farms with in-house manufactured (Farm A) or commercial (Farm B) ESF. The traits derived included feed intake, time spent eating, and rate of feed consumption, averaged across or within specific time periods of gestation. Additional phenotypes included average daily number of feeding events (AFE), along with the cumulative numbers of days where sows spent longer than 30 min in the ESF (ABOVE30), missed their daily intake (MISSF), or consumed below 1 kg of feed (BELOW1). The appetite of sows was represented by averages of score (APPETITE), a binary value for allocation eaten or not (DA_bin), or the standard deviation of the difference between feed intake and allocation (SDA-I). Gilts took longer to eat than sows (15.5 ± 0.13 vs. 14.1 ± 0.11 min/d) despite a lower feed allocation (2.13 ± 0.00 vs. 2.36 ± 0.01 kg/d). The lowest heritability estimates (below 0.10) occurred for feed intake traits, due to the restriction in feed allocation, although heritabilities were slightly higher for Farm B, with restriction in the eating time. The low heritability for AFE (0.05 ± 0.02) may have reflected the lack of recording of nonfeeding visits, but repeatability was moderate (0.26 ± 0.03, Farm A). Time-related traits were moderately to highly heritable and repeatable, demonstrating genetic variation between individuals in their feeding behaviors. Heritabilities for BELOW1 (Farm A: 0.16 ± 0.04 and Farm B: 0.15 ± 0.09) and SDA-I (Farm A: 0.17 ± 0.04 and Farm B: 0.10 ± 0.08) were similar across farms. In contrast, MISSF was moderately heritable in Farm A (0.19 ± 0.04) but lowly heritable in Farm B (0.05 ± 0.07). Heritabilities for DA_bin were dissimilar between farms (Farm A: 0.02 ± 0.02 and Farm B: 0.23 ± 0.10) despite similar incidence. Individual phenotypes constructed from ESF data could be useful for genetic evaluation purposes, but equivalent capabilities to generate phenotypes were not available for both ESF systems.
A study on the reaction mechanism of microwave pyrolysis of oily sludge by products analysis and ReaxFF MD simulation

ABSTRACT The products distributions of oily sludge (OS) pyrolysis was fully explored by combining the pyrolysis experiments and molecular simulation, to help to deeply understand this complicated reaction process. The results of products analysis indicated that the main reactions include chain-breaking reactions, dehydrogenation reactions, aromatization reactions, alkylation reactions, and dehydrogenation condensation reactions. Microwave pyrolysis of model OS comprised of n-dodecane and OS sediment were conducted to further explore the specific reaction during the pyrolysis process, and the results showed that the pyrolysis of saturated alkanes begins at 350℃, and dehydrogenation condensation begins at 500℃. Specifically, saturated alkanes first dehydrogenated to form large molecules of α-alkene, then α-alkenes broke chains to form smaller molecules of alkanes. Furthermore, the pyrolysis process of n-dodecane was simulated by Reactive force field molecular dynamics (ReaxFF MD), and the molecular pyrolysis products distribution obtained by simulation was in good agreement with the experimental result. GRAPHICAL ABSTRACT
Nanotargeting of Drug(s) for Delaying Dementia: Relevance of Covid-19 Impact on Dementia

By incorporating appropriate drug(s) into lipid (biobased) nanocarriers, one obtains a combination therapeutic for dementia treatment that targets certain cell-surface scavenger receptors (mainly class B type I, or “SR-BI”) and thereby crosses the blood-brain barrier. The cardiovascular risk factors for dementia trigger widespread inflammation -- which lead to neurodegeneration, gradual cognitive/memory decline, and eventually (late-onset) dementia. Accordingly, one useful strategy to delay dementia could be based upon nanotargeting drug(s), using lipid nanocarriers, toward a major receptor class responsible for inflammation-associated (cytokine-mediated) cell signaling events. At the same time, the immune response and excessive inflammation, commonly observed in the very recent human coronavirus (COVID-19) pandemic, may accelerate the progression of brain inflammatory neurodegeneration—which increases the probability of post-infection memory impairment and accelerating progression of Alzheimer’s disease. Hence, the proposed multitasking combination therapeutic, using a (biobased) lipid nanocarrier, may also display greater effectiveness at different stages of dementia.
Can reproducibility be improved in clinical natural language processing? A study of 7 clinical NLP suites

Abstract Background The increasing complexity of data streams and computational processes in modern clinical health information systems makes reproducibility challenging. Clinical natural language processing (NLP) pipelines are routinely leveraged for the secondary use of data. Workflow management systems (WMS) have been widely used in bioinformatics to handle the reproducibility bottleneck. Objective To evaluate if WMS and other bioinformatics practices could impact the reproducibility of clinical NLP frameworks. Materials and Methods Based on the literature across multiple researcho fields (NLP, bioinformatics and clinical informatics) we selected articles which (1) review reproducibility practices and (2) highlight a set of rules or guidelines to ensure tool or pipeline reproducibility. We aggregate insight from the literature to define reproducibility recommendations. Finally, we assess the compliance of 7 NLP frameworks to the recommendations. Results We identified 40 reproducibility features from 8 selected articles. Frameworks based on WMS match more than 50% of features (26 features for LAPPS Grid, 22 features for OpenMinted) compared to 18 features for current clinical NLP framework (cTakes, CLAMP) and 17 features for GATE, ScispaCy, and Textflows. Discussion 34 recommendations are endorsed by at least 2 articles from our selection. Overall, 15 features were adopted by every NLP Framework. Nevertheless, frameworks based on WMS had a better compliance with the features. Conclusion NLP frameworks could benefit from lessons learned from the bioinformatics field (eg, public repositories of curated tools and workflows or use of containers for shareability) to enhance the reproducibility in a clinical setting.
Development of a Diabetes-Focused Print Health Literacy Scale Using the Rapid Estimate of Adult Literacy in Medicine Model

Background: A diabetes mellitus (DM)-specific health literacy (HL) measure that focuses on both oral and print HL is needed in clinical and research settings. Objective: The present study developed a psychometrically sound DM-specific HL instrument that measures oral and print HL. Methods: We developed the measure in three steps. First, we reviewed clinical guidelines and conducted focus groups with experts to generate items. Next, we conducted a psychometric evaluation of the scale in three language versions (English, Spanish, and Korean). Lastly, we identified and removed items with potential cultural bias and duplicate functions to produce shorter versions of the scale, using item response theory (IRT). Key Results: We initially developed an 82-item DM-specific oral HL scale using the Rapid Estimate of Adult Literacy in Medicine (DM-REALM) model. To improve the clinical utility of the DM-REALM, we created shorter forms, a 40-item and 20-item version, and evaluated them by using IRT. All DM-REALM versions had high Cronbach alphas (.985, .974, and .945, respectively) and yielded sufficient convergent validity by positive correlations with existing functional HL scale (r = .49, p < .001), education (r = .14, p = .14 to r = .54, p < .001), and DM knowledge (r = .04, p = .70 to r = .36, p < .001). DM-REALM also demonstrated adequate sensitivity as an intervention evaluation tool that captures the changes induced by an intervention. Conclusions: All forms of the DM-REALM tool were reliable, valid, and clinically useful measures of HL in the context of DM care. Both researchers and clinicians can use this tool to assess DM-specific HL across multiple racial and ethnic populations. [HLRP: Health Literacy Research and Practice. 2020;4(4):e237–e249. ] Plain Language Summary: This article reported the process and findings of a newly developed health literacy scale for people with diabetes mellitus using three different language versions. Both long and short versions of the scale demonstrated adequate validity and reliability.
Cognitive processing speed is strongly related to driving skills, financial abilities, and other instrumental activities of daily living in persons with MCI and mild dementia.

BACKGROUND Cognitive processing speed is important for performing everyday activities in persons with Mild Cognitive Impairment (MCI). However, its role in daily function has not been examined while simultaneously accounting for contributions of Alzheimer's disease (AD) risk biomarkers. We examine the relationships of processing speed and genetic and neuroimaging biomarkers to composites of daily function, mobility, and driving. METHODS We used baseline data from 103 participants on the MCI/mild dementia spectrum from the Applying Programs to Preserve Skills trial. Linear regression models examined relationships of processing speed, structural MRI, and genetic risk alleles for AD to composites of performance-based instrumental activities of daily living (IADLs), community mobility, and on-road driving evaluations. RESULTS In multivariable models, processing speed and the brain MRI neurodegeneration biomarker Spatial Pattern of Abnormality for Recognition of Early Alzheimer's disease (SPARE-AD) were significantly associated with functional and mobility composite performance. Better processing speed and younger age were associated with on-road driving ratings. Genetic risk markers, left hippocampal atrophy, and white matter lesion volumes were not significant correlates of these abilities. Processing speed had a strong positive association with IADL function (p < .001), mobility (p < .001), and driving (p = .002). CONCLUSIONS Cognitive processing speed is strongly and consistently associated with critical daily functions in persons with MCI in models including genetic and neuroimaging biomarkers of AD risk. SPARE-AD scores also significantly correlate with IADL performance and mobility. Results highlight the central role of processing speed in everyday task performance among persons with MCI/mild dementia.