Miracle-dz/UniFAR-FTUs huggingface dataset:
Complete mitochondrial genome of the stoat (Mustela erminea) and New Zealand fur seal (Arctocephalus forsteri) and their significance for mammalian phylogeny

Abstract The complete mitochondrial genome of three mustelid species, stoats (Mustela erminea), weasels (Mustela nivalis) and ferrets (Mustela furo), and the New Zealand fur seal (Arctocephalus forsteri) were sequenced using direct mitochondrial DNA extraction and overlapping long PCRs. The usual 37 mammalian mitochondrial genes (13 protein coding genes, 22 t-RNA and 2 r-RNA) were identified in all four mitogenomes. The divergence of stoats from other members of the sub-family Mustelinae was dated 4.5 million years ago. The mitogenomic data were consistent with a bear-like origin of seals.
Cereblon suppresses the formation of pathogenic protein aggregates in a p62-dependent manner

Formation of protein aggregates is the hallmark of neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, and frontotemporal dementia. Many ubiquitin-associated proteins are recruited to protein aggregates, such as sequestosome 1/p62 (p62), parkin, and cereblon (CRBN). However, the roles of these proteins in the regulation of the formation of protein aggregates are not well understood. Here, using cell and animal models, we discover that CRBN directly interacts with p62 and inhibits the formation of protein aggregates induced by mutant huntingtin (Htt-polyQ) and TAR DNA-binding protein 43 (TDP43C) in a p62-dependent manner. Furthermore, we find the suppression of the formation of protein aggregates by CRBN is caused by the decrease of the binding affinity of p62 to ubiquitinated proteins but not by the change of p62 protein level. Our study reveals a novel role of CRBN and the underlying molecular mechanism in the regulation of misfolded proteins in neurodegenerative diseases, which may provide new insights for finding pharmacological targets for these diseases.
Mechanisms and Mediators of the Skeletal Muscle Repeated Bout Effect

Skeletal muscle adapts to exercise-induced damage by orchestrating several but still poorly understood mechanisms that endow protection from subsequent damage. Known widely as the repeated bout effect, we propose that neural adaptations, alterations to muscle mechanical properties, structural remodeling of the extracellular matrix, and biochemical signaling work in concert to coordinate the protective adaptation.
Cognitive impairment and the regional distribution of cerebellar lesions in multiple sclerosis

Background: Cerebellar lesions are often reported in relapsing-remitting multiple sclerosis (RRMS) and have been associated with impaired motor function and cognitive status. However, prior research has primarily focused on summary measures of cerebellar involvement (e.g. total lesion load, gray/white matter volume) and not on the effect of lesion load within specific regions of cerebellar white matter. Objective: Spatially map the probability of cerebellar white matter lesion (CWML) occurrence in RRMS and explore the relationship between cognitive impairment and lesion (CWML) location within the cerebellum. Methods: High-resolution structural magnetic resonance imaging (MRI) was acquired on 16 cognitively impaired (CI) and 15 cognitively preserved (CP) RRMS subjects at 3T and used for lesion identification and voxel-based lesion-symptom mapping (VLSM). Results: CI RRMS demonstrated a predilection for the middle cerebellar peduncle (MCP). VLSM results indicate that lesions of the MCP are significantly associated with CI in RRMS. Measures of cerebellar lesion load were correlated with age at disease onset but not disease duration. Conclusion: A specific pattern of cerebellar lesions involving the MCP, rather than the total CWML load, contributes to cognitive dysfunction in RRMS. Cerebellar lesion profiles may provide a biomarker of current or evolving risk for cognitive status change in RRMS.
Association of triglycerides and new lipid markers with the incidence of hypertension in a Spanish cohort

Objective: Triglycerides and high-density lipoprotein cholesterol (HDL-C) are known to be risk factors for cardiovascular disease. However, there has been limited knowledge on the relationship between triglycerides and incident hypertension. The associations of incident hypertension with triglycerides and triglycerides-related indices such as triglycerides to HDL-C ratio (TG/HDL-C) and triglyceride–glucose index (TyG) were evaluated. Methods: Data from 3637 participants from the Vascular Metabolic Clinica Universidad Navarra cohort were followed-up during a mean of 8.49 years. A Cox proportional hazard ratio with repeated measures analyses was performed to assess the risk of developing hypertension across the quintiles of triglycerides, TG/HDL-C ratio, and TyG index. Results: The risk of developing hypertension was 47% and 73% greater for those in the fourth and fifth quintiles of triglycerides, after adjusting for age, sex, BMI, cigarette smoking, daily alcohol intake, lifestyle pattern, type 2 diabetes, antiaggregation therapy, low-density lipoprotein cholesterol, SBP, and DBP. In men, those in the top quintile of triglycerides, TG/HDL-C ratio or TyG index were two times more likely to develop hypertension than those in the bottom quintile. In women, the effect was attenuated although the risk of hypertension rose with increasing quintiles (P for trend <0.05). The results were consistent when analyses were restricted to those participants without diabetes and obesity at baseline. Conclusions: Our results evidenced the associations between triglycerides-related variables and incident hypertension independently of adiposity. This association was stronger than those observed for other commonly used lipid parameters or lipid ratios, such as the TC/HDL-C ratio. Video abstract: http://links.lww. com/HJH/A620.
Copy-number variations are enriched for neurodevelopmental genes in children with developmental coordination disorder

Background Developmental coordination disorder is a common neurodevelopment disorder that frequently co-occurs with other neurodevelopmental disorders including attention-deficit hyperactivity disorder (ADHD). Copy-number variations (CNVs) have been implicated in a number of neurodevelopmental and psychiatric disorders; however, the proportion of heritability in developmental coordination disorder (DCD) attributed to CNVs has not been explored. Objective This study aims to investigate how CNVs may contribute to the genetic architecture of DCD. Methods CNV analysis was performed on 82 extensively phenotyped Canadian children with DCD, with or without co-occurring ADHD and/or reading disorder, and 2988 healthy European controls using identical genome-wide SNP microarrays and CNV calling algorithms. Results An increased rate of large and rare genic CNVs (p=0.009) was detected, and there was an enrichment of duplications spanning brain-expressed genes (p=0.039) and genes previously implicated in other neurodevelopmental disorders (p=0.043). Genes and loci of particular interest in this group included: GAP43, RBFOX1, PTPRN2, SHANK3, 16p11.2 and distal 22q11.2. Although no recurrent CNVs were identified, 26% of DCD cases, where sample availability permitted segregation analysis, were found to have a de novo rare CNV. Of the inherited CNVs, 64% were from a parent who also had a neurodevelopmental disorder. Conclusions These findings suggest that there may be shared susceptibility genes for DCD and other neurodevelopmental disorders and highlight the need for thorough phenotyping when investigating the genetics of neurodevelopmental disorders. Furthermore, these data provide compelling evidence supporting a genetic basis for DCD, and further implicate rare CNVs in the aetiology of neurodevelopmental disorders.
Molecular Regulation of Histamine Synthesis

Histamine is a critical mediator of IgE/mast cell-mediated anaphylaxis, a neurotransmitter and a regulator of gastric acid secretion. Histamine is a monoamine synthesized from the amino acid histidine through a reaction catalyzed by the enzyme histidine decarboxylase (HDC), which removes carboxyl group from histidine. Despite the importance of histamine, transcriptional regulation of HDC gene expression in mammals is still poorly understood. In this review, we focus on discussing advances in the understanding of molecular regulation of mammalian histamine synthesis.
High selectivity and ultra-wide stopband microstrip lowpass filter using high-low impedance resonators

A compact microstrip lowpass filter is designed to obtain high selectivity and extra-wide stopband up to 10th harmonic suppression. To improve the selectivity and make the filter structure compact, folded high-low impedance resonators are used. For achieving high relative stop bandwidth (163%), modified hexagonal shaped resonators and open stubs as suppressing cells are employed. The proposed filter has 3 dB cutoff frequency of 1.85 GHz. An ultra-wide stopband bandwidth of 2.04 GHz to 20 GHz has been achieved at 20 dB suppression level. A sharp transition range of 0.275 GHz is obtained between the cutoff frequency and −40 dB attenuation level. The LC equivalent circuit model of the proposed filter is developed and simple circuit analysis method is used to extract the values of parameters.
Quantitating hair loss in women: a critical approach.

BACKGROUND Assessing how many hairs are actually shed by patients complaining of hair loss is a difficult task. Many methods have been proposed, but all need standardization. METHODS We examined 234 women complaining of hair loss. Alopecia areata and scarring alopecias were excluded. Eighty-nine of the patients had an apparently normal density of hair. Seventy-four were classified as Ludwig stage I, 37 as Ludwig II and 15 as Ludwig III. In 19 patients, classification had not been recorded. They were tested with the pull test (PT), daily count (DC) and wash test (WT). Telogen percentage was obtained by a trichogram in 43 patients. RESULTS Dispersion of the data was very high. The medians of the PT, DC and WT were 0.6, 60.5 and 122 hairs, respectively. The telogen median of percentage was 16. In patients with normally dense hair, the PT, DC and WT means were significantly higher than in those with Ludwig stages I-III. Telogen means did not differ. WT values correlated significantly with those of the DC and PT, and DC values did so with those of the PT. By contrast, telogen percentage did not correlate with WT, DC and PT values. WT values and telogen percentage increased in autumn, the latter preceding the WT by 1 month. CONCLUSIONS The methods adopted and the problem of 'normality' are critically analyzed. Subjects complaining of hair loss proved to shed a higher number of hairs than those with various degrees of baldness. The PT is a poorly sensitive method, while telogen percentage is not correlated with the severity of hair loss. As the DC is a cumbersome procedure, the WT is probably the best method to adopt. Standardization of methods and assessment of normality in prepubertal children are imperative.
Body image and nonsuicidal self-injury: Validation of the Body Investment Scale in participants with eating disorders.

The Body Investment Scale (BIS) assesses body image feelings, body care, protection of the body, and comfort in touch, in order to identify and distinguish participants with self-harming and self-destructive tendencies. However, the psychometric properties of the BIS were not analysed in participants diagnosed with eating disorders. The main objective of the present study is to confirm the factor structure of the Spanish version of the BIS and analyse its psychometric properties in a sample composed of women diagnosed with eating disorders. Participants were 250 Spanish women between 12 and 60 years old (M = 26.05, SD = 11.97) diagnosed with eating disorders. A confirmatory factor analysis showed a poor fit of the original BIS. The final model showed an acceptable 4-factor structure (Body Feelings, α = .88; Body Touch, α = .82; Body Protection, α = .77; Body Care, α = .68), with a good fit to the data (SBχ2(246) = 393.21, CFI = . 906, IFI = . 908, RMSEA = . 049). The relationships between the BIS and both the Purpose-In-Life Test-10 Items and Beck Hopelessness Scale were analysed, as well as differences in the BIS score according to nonsuicidal self-injuries and suicidal ideation in the past year. The BIS is an appropriate instrument to assess the body investment dimension of body image in women with eating disorders.
Adolescents' behavioral and neural responses to e‐cigarette advertising

Although adolescents are a group heavily targeted by the e‐cigarette industry, research in cue‐reactivity has not previously examined adolescents' behavioral and neural responses to e‐cigarette advertising. This study addressed this gap through two experiments. In Experiment One, adult traditional cigarette smokers (n = 41) and non‐smokers (n = 41) answered questions about e‐cigarette and neutral advertising images. The 40 e‐cigarette advertising images that most increased desire to use the product were matched to 40 neutral advertising images with similar content. In Experiment Two, the 80 advertising images selected in Experiment One were presented to adolescents (n = 30) during an functional magnetic resonance imaging brain scan. There was a range of traditional cigarette smoking across the sample with some adolescents engaging in daily smoking and others who had never smoked. Adolescents self‐reported that viewing the e‐cigarette advertising images increased their desire to smoke. Additionally, all participants regardless of smoking statuses showed significantly greater brain activation to e‐cigarette advertisements in areas associated with cognitive control (left middle frontal gyrus), reward (right medial frontal gyrus), visual processing/attention (left lingual gyrus/fusiform gyrus, right inferior parietal lobule, left posterior cingulate, left angular gyrus) and memory (right parahippocampus, left insula). Further, an exploratory analysis showed that compared with age‐matched non‐smokers (n = 7), adolescent smokers (n = 7) displayed significantly greater neural activation to e‐cigarette advertising images in the left inferior temporal gyrus/fusiform gyrus, compared with their responses to neutral advertising images. Overall, participants' brain responses to e‐cigarette advertisements suggest a need to further investigate the long‐run impact of e‐cigarette advertising on adolescents.
Named entity recognition for Psychological domain: Challenges in document annotation for the Arabic Language

The named entity extraction to improve not only the keyword search but become an essential element for semantic annotation and it opened the door for recognition of medical named entities which is a difficult task for the extraction of information and understanding of the natural language. Considerable work has been done for the semantic annotation of the biomedical text, in particular English, thanks to the variety of tools available for this language. In this article we propose an approach for the semantic annotation of psychological texts in Arabic based on the named entity. Two techniques were applied for the recognition processes: the first requirement prior to the technique was completely dependent on direct identification with the utilization of gazetteers and the second technique is a rule-based model in which rules are techniques were put constructed on the basis of a gazetteers list. Experiments yield the overall Fmeasure values of 86,407.
Mining traffic accident data of N5 national highway in bangladesh employing decision trees

Mining traffic accident data is necessary for accident free smart cities, as traffic accidents causes harmful injuries, loss of lives and damages properties of people. N5 National Highway in Bangladesh is the largest highway, where a large number of accidents occur in every year. In this paper, we have analyzed and found the traffic accident patterns of N5 National Highway in Bangladesh using several decision tree induction algorithms. Decision tree is one of the most popular algorithms in machine learning and data mining. We have analyzed total 892 traffic accidents. The traffic accidents data of N5 National Highway of Bangladesh was collected from Modular Accident Analysis Program version 5, Accident Research Institute, Bangladesh University of Engineering and Technology. We have extracted the informative features from the traffic accident data and generated several classifiers using different decision tree algorithms. In the experimental analysis, we have compared the performance of 12 decision tree classifiers and find the best classifier. Finally, we have extracted rules for the trees to avoid traffic accidents in the N5 National Highway of Bangladesh.
Neurologic Changes and Depression

Late-life depression affects 3.0% to 4.5% adults older than 65 years in the United States. For many older adults with depression, affective symptoms are accompanied by cognitive difficulties, which can range from subjective cognitive complaints to mild cognitive impairment (MCI) to dementia. Epidemiologic findings suggest that late-life depression may be a risk factor for dementia. Given the relatively high prevalence of depression in older adults and a growing focus onmodifiable risk factors for dementia, there is interest in better understanding the complex relationship between depression and cognitive impairment. This review focuses on individuals with unipolar depression without psychotic features with comorbid MCI or dementia. To align with the
A trajectory reconstruction approach for leader-following of multi-robot system

A trajectory reconstruction approach is proposed for accurate leader-following with a desired separation distance on the trajectory. The approach aims to reconstruct the relative trajectory of the leader within a sliding time window based on the on-board sensors. The needed trajectory information of the leader relative to the follower is acquired by combining the noisy and intermittently available visual measurement with the odometry information. The situation that the leader is out of filed of view (FOV) is also taken into consideration. Moreover, instead of following the current pose of the leader, the trajectory information of a historical point on the trajectory is used as the reference input for controller, thereby avoiding the cutting-corner issue. Simulation results demonstrate the effectiveness of the proposed trajectory reconstruction approach.
The Fine-Grained Topic Evolution Based on the Probability Model

Nowadays online social media like Weibo is gradually replacing the traditional Internet services, being a convenient and swift approach for information diffusion and access. Tracking the evolution of the topic and the trend of the situation according to the user-interested aspect across the social network has been an issue of considerable interest and has not been fully investigated. Prior research on topic evolution has often refinements to the full-analysis topic models which typically perform full analysis on the whole data to identify all emerging topics. However, such methods do not perform more detailed topic evolution analysis users always want on some specific aspects. In this study, we present a model based on targeted topic model that automatically discover and summarize the fine-grained evolutionary patterns of topics in a text stream. We evaluate our method on a Weibo stream containing over ninety thousand weibos. Experimental results show that the proposed method can discover the fine-grained evolutionary patterns of topic effectively.
Mechanical thrombectomy – is time still brain? The DAWN of a new era

Abstract Purpose: The purpose of this study is to review the history of treatments for acute ischemic stroke, examine developments in endovascular therapy, and discuss the future of the management of acute ischemic stroke. Methods: A selective review of recent clinical trials for the treatment of acute ischemic stroke was conducted. Results: We reviewed completed trials of the management of acute ischemic stroke including intravenous thrombolytics, intraarterial thrombolytics, and thrombectomy. We also assessed the future direction of research by reviewing ongoing clinical trials. Conclusions: The advancement of endovascular treatment for stroke has led to improved morbidity and mortality for patients. Future challenges include delivering these treatments to stroke centers worldwide.
Cyclical Behavior of Fiscal Policy in the Western Balkans

This paper studies the cyclical behavior of fiscal policy in the Western Balkans region, investigating empirically the fiscal policy response to business cycles for the period 2003-2016. Although there is a large empirical literature which has found that fiscal policy in developing countries is pro-cyclical, not many studies are found on the Western Balkans region, with only a few done at country level. We apply the Hodrick-Prescott (HP) filter and other filters to measure the potential output and output gap for each of the respective Western Balkans countries. By performing country regressions we find that one of the main determinants fiscal pro-cyclicality in the WB6 region is the quality of the government. We conduct a series of structural vector auto-regressions (SVAR) for each of the countries in an attempt to obtain further evidence on the reaction of fiscal policy to the business cycle.
Outage Performance Analysis on Multiuser Linear Network Coded Cooperation System Considering Path Loss

Linear network coded cooperation (LNCC) is a new technology that combines linear network coding and cooperative communication. LNCC can dramatically reduce system outage probability and hence increase spectrum efficiency. The outage performance considering path loss is essential for further system optimizations for LNCC, such as optimal power allocation and optimal relay selection. However, as far as we know, this issue still remains open. In this paper, we investigate the outage performance of a two-slot multiuser LNCC system in many-to-one communication mode. We fully consider the effect of pathloss in the process of theoretical analysis and theoretically derive the tight approximated outage probability of LNCC system. And the analytic results are verified by Monte Carlo simulations. Numerical results show that two-slot LNCC system with path loss is able to greatly improve the outage performance.
A mobile robot navigation method using a fuzzy logic approach

Summary This paper treats, in a general way, the problem of mobile robot navigation in a totally unknown environment. The different aspects of this problem are dealt with one by one. We begin by introducing a simple method for perceiving and analyzing the robot's local environment based on a limited amount of distance information. Using this analysis as our base, we present a navigation algorithm containing different action modules; some of these actions use Fuzzy Logic. The results presented whether experimental or simulation show that our method is well adapted to this type of problem.
Impact of mobile tangible slider design and its reachability on pointing performance

Touch interaction is almost omnipresent on mobile devices and technological advances have made screens bigger. The users can then interact with more content displayed on screen but it is more difficult for the users to reach all the parts of the screen with one thumb. At the same time, researchers are exploring mobile interaction with deformable tangible interfaces. Bringing tangible objects to the flat screen brings a new perspective on the reachability problem of the thumb. In this work, we explore the impact on performance for thumb interaction within and outside the functional area of the thumb, while operating a tangible slider. Experimental results demonstrate that the size of the motor space has a significant impact on performance. Operations within and outside the easily reachable area of the thumb show marginal difference of performance.