Miracle-dz/UniFAR-FTUs huggingface dataset:
Aggregation‐enhanced theranostics: AIE sparkles in biomedical field

Theranostics referring to the ingenious integration of diagnostics and therapeutics has garnered tremendous attention in these years as it provides a promising opportunity for modern personalized and precision medicine. By virtue of the good biocompatibility, outstanding fluorescence property, easy processability and functionalization, promoted photosensitizing efficiency, as well as facile construction of multi‐modality theranostics, fluorophores with aggregation‐induced emission (AIE) characteristics exhibit inexhaustible and vigorous vitality in the field of theranostics. Numerous significant breakthroughs and state‐of‐the‐art progression have been witnessed in the past few years. This review highlights the tremendous aggregation‐enhanced superiorities of AIE luminogens (AIEgens) in disease theranostics mainly involving diagnostic imaging (fluorescence and room temperature phosphorescence), therapeutic intervention (photodynamic therapy), and feasibility in construction of multi‐modality theranostics based on the experimental measurements and theoretical simulations. Additionally, the latest and advanced developments of AIEgens in disease theranostics in the aspect of corresponding strategies to design highly effective AIE‐active theranostics through triggering aggregation formation are comprehensively summarized. Moreover, a brief conclusion with the discussion of current challenges and future perspectives in this area is further presented.
A Strategy for Identifying the Risk of Developing Alzheimer's Disease From Healthy Controls: Distance to Novelty Detection Boundary

Background:Machine learning (ML) techniques are expected to tackle the problem of the high prevalence of Alzheimer’s disease (AD) we are facing worldwide. However, few studies of novelty detection (ND), a typical ML technique for safety-critical systems especially in healthcare, were engaged for identifying the risk of developing cognitive impairment from healthy controls (HC) population.Materials and Methods: Two independent datasets were used for this study, including the Australian Imaging Biomarkers and Lifestyle Study of Ageing (AIBL) and the Fujian Medical University Union Hospital (FMUUH), China datasets. Multiple feature selection methods were applied to identify the most relevant features for predicting the severity of AD. Four easily interpretable ND algorithms, including k nearest neighbor, Mixture of Gaussian (MoG), KMEANS, and support vector data description were used to construct predictive models. The models were visualized by drawing their decision boundaries tightly surrounding the HC data. A distance to boundary (DtB) strategy was proposed to differentiate individuals with mild cognitive impairment (MCI) and AD from HC. Results: The best overall MCI&AD detection performance in both AIBL and FMUUH was obtained on the cognitive and functional assessments (CFA) modality only using MoG-based ND with AUC of 0.8757 and 0.9443, respectively. The highest sensitivity of MCI was presented by using a combination of CFA and brain imaging modality. The DTB value reflects the risk of developing cognitive impairment for HC and the dementia severity of MCI/AD.Conclusions: Our findings suggest that applying some non-invasive and cost-effective features can significantly detect cognitive decline in an early stage. The visualized decision boundary and the proposed DtB strategy illustrated the severity of cognitive decline of potential MCI&AD patients in an early stage. The results would help inform future guidelines for developing a clinical decision-making support system aiming at an early diagnosis and prognosis of MCI&AD.
For obese postmenopausal women, what options may decrease endometrial cancer risk?

E ndometrial cancer is the most common gynecologic ma lignancy, with approximately 59,000 cases diagnosed annually, and a lifetime risk of approximately 3.1% in the United States. Type I endometrial cancer includes tumors with endometrioid histology that are grade 1 or 2. Type II endometrial cancer includes tumors that have grade 3 endometrioid or nonendometrioid histology, including serous, clear cell, mucinous, squamous transitional cell, mesonephric, and undifferentiated tumors. Type I endometrial cancer is hormone sensitive, generally stimulated by estrogen and suppressed by progestins. Endometrial cancer is diagnosed at a mean age of 63 years, and only 15% of cases occur before age 50. Women with an elevated body mass index (BMI) have a markedly increased risk of both Types I and II endometrial cancer (TABLE, page 10). Hence, endometrial cancer is highly prevalent in obese postmenopausal women. For these women health interventions that may reduce the risk of developing endometrial cancer include dieting, physical activity, bariatric surgery, and progestin therapy.
A review on security challenges and approaches in the cloud computing

Cloud Computing is a model based on computing system which provides convenient and customizable services to the users for accessing to different cloud applications. It provides a way for storing and accessing cloud data from anywhere via connecting the cloud application utilizing internet. The cloud computing and its related safety problems is one of widely discussed concerns in today generation's research field. While numerous cloud security investigations are previously widespread, there residues a definite distance in properly identifying these issues and find the appropriate solutions. Some studies discuss the problems of virtualization and approach the target, while others talk about access control mechanisms, but what's missing is a standard framework which simultaneously extends the concept of cloud security and describes its specific requirements. In addition, countermeasures given in a survey must clearly illustrate the problem it deals with. This analysis paper took all of these elements into consideration so that the necessary areas were properly connected and a number of open issues were discussed in this area. This paper also reviews the most significant security techniques to data protection and cloud security in the cloud computing. Moreover, security techniques for data protection will be recommended in order to have enhanced security in cloud computing. It will concentrate primarily on issues related to data security and provides solutions.
Biofeedback Posture Training for Adolescents with Mild Scoliosis

Adolescent idiopathic scoliosis (AIS) is characterized by uneven shoulders, spinal curvature, and uneven hips, and asymmetry in paraspinal muscle activities is common in AIS. This pilot study was aimed at examining the use of a surface electromyography (sEMG) biofeedback posture training program in adolescents with mild scoliosis (Cobb′s angle < 30°) to attenuate asymmetry in paraspinal muscle activities and control the curve progression. Seven female adolescents (age, 12–14 years) with mild scoliosis (Cobb′s angle < 30°) were recruited. The participants received 30 tailor-made sessions of sEMG biofeedback posture training at a rate of one to two sessions per week for approximately 6 months. The activities of the paraspinal muscles (the trapezius, latissimus dorsi, thoracic erector spinae, and lumbar erector spinae) measured by sEMG during habitual sitting postures and spinal deformity evaluated by 3D ultrasound imaging were compared before and after training. The mean values of the root-mean-square sEMG ratio, an index of symmetry in paraspinal muscle activities of the muscle pairs between the concave and convex sides of the spinal curve, revealed significant asymmetry over the trapezius and lumbar erector spinae before the training (p <0.05). After the training, all seven adolescents achieved relatively more symmetrical paraspinal muscle activities over these two muscle pairs (p < 0.05). In two adolescents, the spinal curvature decreased by 5.7° and 5.6°, respectively, whereas the remaining adolescents showed a minimal curve progression with changes in the spinal curvature controlled under 5°. To conclude, sEMG biofeedback posture training can reduce asymmetry in paraspinal muscle activities and control curve progression in adolescents with mild scoliosis and can potentially be considered an alternative early intervention for muscle reeducation in this cohort.
Detection of SARS-CoV-2 virus using acute respiratory infections sentinel surveillance system (PIDIRAC) in Catalonia (Spain)

In the context of the Covid-19 pandemic in Catalonia (Spain), the first SARS-CoV-2 case confirmed was notified to the Catalonia Epidemiological Surveillance Network (RVEC) on 25 February 2020. The present study describes and analyses the respiratory samples obtained in primary care using PIDIRAC epidemiological sentinel surveillance system to complement the pandemic surveillance system activated, and describe whether SARS‑CoV-2 was circulating before the first case detected in Catalonia, between October 2019 and April 2020.During this period, 878 respiratory samples from patients with acute respiratory infection or influenza syndrome obtained by PIDIRAC epidemiological sentinel surveillance system were analysed. Of the total sample, 51.9% tested positive to influenza virus and 48.1% to other respiratory viruses, with SARS-CoV-2 being present in 6 samples. The first SARS‑CoV‑2 positive case showed the first symptoms on 2 March 2020. These were 3 men and 3 women aged between 25 and 50 years old (mean age 44.5 years old). Fever, general discomfort, coughing, chills, and arthromyalgia were the most frequent symptoms in the SARS-CoV-2 cases. Likewise, 44 samples that had tested positive for coronavirus during 2018-2019 were typed. They were all typed as one of the regular CoV, none of them being SARS-CoV-2.The acute respiratory infections sentinel surveillance system (PIDIRAC) reinforces the global epidemiological surveillance, allows to corroborate whether there is virus circulation or not, and helps confirm that generalised community transmission in Catalonia took place in mid-March.
Fast 3D reconstruction based on UAV image

3D reconstruction for outdoor large environment, especially with high efficiency and robustness, has triggered increasing attention in both civilian and military scenario. This paper proposes a rapid method to perform 3D reconstruction using openMP multithreading strategy. The GPS information will be adopted to determine the adjacent relationship between images. The map will be processed through mesh blocks to save the computational time, and will be finally optimized by the mesh dissecting algorithm to remove holes. The experimental results show that the processing speed has been increased as five times faster than the methods based on openMVG and openMVS with better reconstruction outputs.
A Network Pharmacology Approach to Investigating the Mechanism of Sophorae Flavescentis Radix for the Treatment of Lung Cancer

In this study, the bioactive components and predictive targets of Sophorae Flavescentis Radix were investigated by network pharmacology analysis, so as to further elucidate its potential biological mechanism in treating lung cancer. The targets corresponding to lung cancer were obtained by OMIM and Genecards. By intersecting with the targets of Sophorae Flavescentis Radix and lung cancer, the Sophorae Flavescentis Radix-lung cancer targets were obtained. Protein-protein interaction network was constructed by an online database STRING and hub genes were screened by Cytoscape 3.7. 0 software. ClusterProfiler package was used to analyze Gene ontology (GO) and KEGG enrichment of the targets in R. A total of 45 bioactive components were screened from Sophorae Flavescentis Radix, corresponding to 482 Sophorae Flavescentis Radix targets and 25019 lung cancer targets. According to the GO and KEGG enrichment analysis, Sophorae Flavescentis Radix played a therapeutic role in treating lung cancer via proteoglycans lung cancer, human cytomegalovirus infection, microRNAs in cancer, PI3K-Akt signaling pathway, etc. Seven hub genes (IL6, CASP3, EGFR, VEGFA, MYC, CCND1 and ESR1) were screened by degree algorithm. In a word, the results of this study may provide novel insights into the mechanisms of Sophorae Flavescentis Radix in treatment of lung cancer.
Aberrant activation of the Hedgehog signaling pathway in granulosa cells from patients with polycystic ovary syndrome

ABSTRACT The molecular mechanism that triggers polycystic ovary syndrome (PCOS) is mysterious. Abnormal development of ovarian granulosa cells (GCs) is one of the causes of PCOS. Herein, our study was carried out using RNA-seq to detect the different gene expression levels in ovarian GCs between three patients with PCOS and four normal controls. To verify the RNA-seq data, GCs from 22 patients with PCOS and 21 controls with normal ovulation were collected to perform the RT-PCR analysis. Hedgehog signaling pathway (Hh) members, Ihh and Ptch2 were abnormally highly expressed in the PCOS tissue (PT). The qPCR also indicated that the expression levels of Hh signaling pathway downstream members, Ptch1, Gli1, and Gli2 in the PT were significantly higher than those in the normal tissue (NT). Besides, the expression of TNF-α mRNA in PCOS patients was higher than that in the control group. Through the chromatin immunoprecipitation assay (ChIP), we found that the Gli1-IP-DNA enriched from the granular cells of PCOS patients was higher than that of the control group. Finally, the Hh signaling pathway inhibitor, cyclopamine, can decrease the apoptosis of PCOS ovarian granulosa cells. These results suggest that abnormal activation of Hh signaling pathway, especially Ihh signal, may have a profound influence on PCOS.
Gabor Filter and Moment Invariant via LDA Classifier for Skin Cancer Detection

Skin cancer may be a serious tumor. This can be clearly seen through the mature, uncommon appearance of fur pathology, which has abnormal properties in complex situations, wrinkled or uncertain perimeters, and dual colors. A small number of tulle melanomas of uncertain diameter can imitate benign moles and cannot be perceived by optical inspection. The only assumption for analyzing them is through dermoscopy as an option. Original identification and medical surgery can alternative for the patients. Within this research a detection method through image processing with various feature extraction such as Gabor filter and Hu Moment were employed and substantially improves the diagnosis performance with 97% via LDA Classifier.
Microtubules dual chemo- and thermo-responsive depolymerization & optimization of noncovalent loading of vinblastine on single-walled carbon nanotube

The effects of the chemotherapeutic agent vinblastine versus the low temperature of 277 K on the structure of αβ-tubulin heterodimer were investigated by means of molecular dynamics simulations. Individual experiments have shown that vinblastine-bound heterodimer, and its apo structure under low temperature of 277 K, both undergo conformational changes toward destabilization of the dimer as compared to the apo tubulin at 300 K. Both factors exhibit weakening the longitudinal interactions of tubulin heterodimer through displacing dimer interfacial segments, resulting in the dominant electrostatic repulsion at the interface of the subunits. The two independent factors of temperature and anti-mitotic agent facilitate folding alterations in the functional segments of H1-S2 loop, H3, H10 helices and T7 loop, which are known to be important in either longitudinal or lateral contacts among αβ-heterodimers in microtubule protofilaments and the depolymerization mechanism of microtubules. Carbon nanotubes have become one of the candidates for transporting drugs to target sites, because of their size scale, huge surface area and high cellular uptake. Many experimental studies of carbon nanotube drug delivery have been performed in the past decade. The delivery studies of vinblastine and its target microtubule are important, because of the significant role of vinblastine in cancer therapy. However, the interactions between vinblastine and carbon nanotubes have yet to be investigated. The computational studies of the interactions between vinblastine and carbon nanotubes under different conditions are presented in this thesis. The vinblastine-carbon nanotube interactions have been studied from the following perspectives: loading capacity (one to three vinblastine molecules loaded); tube structure (armchair, chiral and zigzag tubes); tube functionalization; and temperature variations (277 K and 300 K). The functionalization of carbon nanotubes strengthened the drug-carrier interactions of all systems at 300 K. The functionalized carbon nanotubes of armchair type were identified suitable for drug delivery at both 277 K and 300 K, due to the relatively strong drug-carrier interactions. The functionalized chiral nanotubes were found especially useful for delivery at 277 K due to the enhanced drug-carrier interactions at this temperature.
Relationships among emotional blackmail, job frustration, turnover intention for tour leaders

ABSTRACT Due to the nature of their work, tour leaders need to interact closely with the tour members; thus, the former are often subjected to emotional blackmail by the latter. Therefore, this study investigated the relationship among tour leaders’ perceived emotional blackmail, job frustration, and turnover intention. Licenced tour leaders were chosen as participants of this study and were asked to answer a self-administered survey questionnaire. A total of 355 valid questionnaires were collected at the end of the study period. The results showed that the higher the tour leaders’ perceived blackmail, the higher the job frustration and the turnover intention are. Furthermore, based on the results, job frustration has a positive effect on turnover intention.
Development of Detector Control System (DCS) for forward hadron calorimeters in the BM@N and the MPD experiments

The BM@N and the MPD experiments at NICA facility (Dubna, Russia) will use the forward hadron calorimeters (FHCal) for centrality and reaction plane determination in the heavy ion collisions. The FHCal is a modular lead/scintillator sampling calorimeter with longitudinal segmentation. The light from each longitudinal section in module is detected with one silicon photomultiplier (MPPC) with sensitive area of 3x3mm2. In total, the FHCal at the BM@N experiment has 438 readout channels, while two MPD calorimeter arms have 616 readout channels. This article shows the DCS design with hardware and software development for these calorimeters. The DCS will be used to control and correct the bias voltages with temperatures of MPPCs. An integration into the main DCS systems for both experiments are discussed.
Primary drug-related crime in the Czech Republic from a geographical perspective: study of urban, suburban and rural differences

Illicit drug use and drug-related crime constitute a significant issue and create large economic and societal costs both at national and regional level. The aim of this article is to examine the differences in primary drug-related crime between urban, suburban and rural local police departments in Czechia. The primary drug-related crime rate in local police departments was constructed from the data collected in the national crime database and the geographical classification of these departments was taken from previous research. To analyze the differences among urban, suburban and rural departments, we used the general linear model. The models with measures that were not standardized for the number of inhabitants were all significant, while not all the models with standardized measures were significant. Overall primary drug-related crime, unauthorized production and other handling of illicit drugs and possession of illicit drugs models with standardized measures showed no significant differences between departments. The cultivation of plants model with standardized measure shows an increase in the predicted values of independent variables in suburban and rural departments compared to urban departments. Our research results show that local urban police departments are not related to higher rates of standardized primary drug-related crime, although there are differences in specific drug law offences. It suggests that drug-related issues are prevalent in all types of departments, however, the specific issues differ between them. Conclusions: The research showed that standardized primary drug-related crime rate in urban departments is not higher than in suburban or rural local police departments.
The Colombian Political Agendas Project: analysing presidential attention during the administrations of Uribe and Santos (2002-2018)

Abstract This article has two interrelated objectives: to introduce the Colombian Political Agendas Project (COL-PAP) and offer an exploratory example of the applications of its databases. As a prelude, we describe some characteristics of the Colombian political system and the presidents analyzed. The study presents the objectives of COL-PAP, the creation of the codebook and the databases built so far, with special attention to the databases gathering bills and CONPES documents. The example discussed explores the dynamics of presidential attention in the period 2002-2018, especially the attention distributed among public policy issues over time, and its allocation among instruments. The study shows that attention varies among issues, but also that it is assigned differently between instruments, according to the opportunity structure they offer. Inspired in the discussion and findings related to the databases built so far for COL-PAP, the study suggests future lines of research for Colombia, Latin America, and the CAP in general.
The Effect of Top Executive Turnover and Local Market Characteristics on Financial Reporting Risk

Upper echelon theory posits that defining, executing, and overseeing an organization’s strategy is a shared activity among top executives. Based upon this perspective, we expect turnover among the members of a firms’ top management team (TMT) other than the CEO and CFO to result in significant disruption to an organization’s operations, leading to greater uncertainty regarding its future performance, execution of operational strategies, and financial reporting decisions. In this study, we explore whether TMT turnover affects stakeholders’ perceptions of financial reporting risk. We find that TMT turnover is positively associated with audit fees which reflects auditors’ and audit committees’ assessments of financial reporting risk. Importantly, building upon labor economics literature, we find that TMT turnover’s effect on stakeholders’ perceptions of financial reporting risk is greater for companies headquartered where there are more limited local labor pools and companies that are market leaders in their local areas or industries. Further analyses suggest that increased audit fees offset deterioration in financial reporting quality as TMT turnover increases.