Miracle-dz/UniFAR-FTUs huggingface dataset:
Using Machine Learning Classification Methods to Detect the Presence of Heart Disease

Cardiovascular disease (CVD) is the most common cause of death in Ireland, and probably, worldwide. According to the Health Service Executive (HSE) cardiovascular disease accounting for 36% of all deaths, and one important fact, 22% of premature deaths (under age 65) are from CVD. [2] Using data from the Heart Disease UCI Data Set (UCI Machine Learning), we use machine learning techniques to detect the presence or absence of heart disease in the patient according to 14 features provide for this dataset. The different results are compared based on accuracy performance, confusion matrix and area under the Receiver Operating Characteristics (ROC) curve in order to choose the best model to fix the situation and provide a predictive model for detect heart disease. Finally, it is used a hierarchical learning technique and deep learning (H2O 3.8.2.6.) to compare the previous results. [16][17][18]
Perceived Risk and Hazards Associated With Home Health Care Among Home Health Nurses of India

The objective of this study is to categorize the home health nursing care activities and hazards applicable to Indian settings, into high, medium, and low priority levels with the help of risk assessment table and risk matrix. The research design is exploratory and the study is cross-sectional, A self-administered questionnaire is prepared for Indian settings based on the literature review; the content validity and the internal consistency were ensured; the mean scores and the frequencies for the activities were calculated. The severity scores for the identified 14 perceived high-risk activities were assigned with the help of the brainstorming session. The hazard of slippery floors and exposure to blood fell into high priority area (denoted by red area) with high severity and high occurrence score, similarly overloaded and unsafe electrical outlets, rushing with clients, time pressure for reaching the client’s home, and contact with chemicals fell into medium priority category (denoted by yellow area). Finally, hazards such as uncontrolled pets and verbal abuse from patients fell into low priority levels. The providers should take measures for hazards such as slippery floors, overloaded and unsafe electrical outlets, rushing with clients, time pressure for reaching the client’s home, exposure to blood, and contact with chemicals, as these hazards fell into high-medium severity rating with high-medium probability.
Resource allocation in downlink SWIPT-based cooperative NOMA systems

This paper considers a downlink multi-carrier cooperative non-orthogonal multiple access (NOMA) transmission, where no direct link exists between the far user and the base station (BS), and the communication between them only relies on the assist of the near user. Firstly, the BS sends a superimposed signal of the far and the near user to the near user, and then the near user adopts simultaneous wireless information and power transfer (SWIPT) to split the received superimposed signal into two portions for energy harvesting and information decoding respectively. Afterwards, the near user forwards the signal of the far user by utilizing the harvested energy. A minimum data is required to ensure the quality of service (QoS) of the far user. We jointly optimize power allocation, subcarrier allocation, time allocation, the power allocation (PA) coefficient and the power splitting (PS) ratio to maximize the number of data bits received at the near user under the energy causality constraint, the minimum data constraint and the transmission power constraint. The block-coordinate descent method and the Lagrange duality method are used to obtain a suboptimal solution of this optimization problem. In the final simulation results, the superiority of the proposed NOMA scheme is confirmed compared with the benchmark NOMA schemes and the orthogonal multiple access (OMA) scheme.
Pseudomolecules and annotation of the second version of the reference genome sequence assembly of barley cv. Morex [Morex V2]

DNA sequence file in FASTA format for chromosomal pseudomolecules of barley (Hordeum vulgare) cv. Morex. This is the second release (Morex V2) of the Morex genome sequence assembly, improving on the Morex V1 release by Mascher et al. 2017, Nature [doi:10.1038/nature22043]. Sequence assembly was performed with the TRITEX pipeline (https://tritexassembly.bitbucket.io). Intermediate results (unitig, scaffold and super-scaffold sequences) are provided in the folder 'contig_and_scaffold_sequences'. The folder 'gene_annotation' holds the structural gene annotation of the Morex V2 assembly: gene models in GFF3 format, their functional descriptions as well as coding and protein sequences of high- and low-confidence genes. The folder 'repeat annotation' contains GFF files specifying the positions of transposable elements and tandem repeats. A table with the approximate centromere positions is found in the folder 'centromere_positions'.
Effects of economic growth, foreign direct investment and internet use on child health outcomes: empirical evidence from South Africa

ABSTRACT This study examines the effects of economic growth and foreign direct investment (FDI) on child health outcomes measured by Infant Mortality Rate (IMR) and Child Mortality Rate Under 5 (CMRU5) with several control variables such as corruption, inequality and HIV among others. It analyzes South Africa's annual time series data for the period 1985–2016. As variables were found with mixed order of integration, Autoregressive Distributed Lag (ARDL) model is applied to determine cointegration and estimate short-run and long-run coefficients. Results indicate that economic growth and FDI have negative significant effects on both indicators of child health outcomes in both the short run and the long run. This implies that both economic growth and FDI contribute towards reducing IMR and CMRU5 in South Africa and thus help improve child health outcomes. Toda and Yamamoto (TY) causality test confirms causal association between these variables. Policy implications are discussed.
El factor de crecimiento endotelial vascular (VEGF) y el fragmento N-terminal de la proteína relacionada con la parathormona (PTHrP) regulan la proliferación de células madre mesenquimales humanas

espanolEl tejido adiposo contiene un gran numero de celulas madre mesenquimales (Adipose Stem Cells, ASCs) que residen en su estroma vascular. Aunque existe controversia acerca de la capacidad de generar tejido oseo de estas celulas in vivo, in vitro constituyen un buen modelo de diferenciacion osteogenica debido a su semejanza fenotipica con las celulas estromales de la medula osea (Bone Marrow Stromal Cells, BMSCs) en cultivo. La diferenciacion de las poblaciones osteoprogenitoras de la medula osea esta intensamente regulada por factores locales, como el factor de crecimiento endotelial vascular (VEGF) y la proteina relacionada con la parathormona (PTHrP), que modulan la proliferacion de estas poblaciones en distintos estadios de diferenciacion. Tanto el VEGF como el fragmento N-terminal de la PTHrP ejercen efectos osteogenicos. En este estudio hipotetizamos que sus efectos sobre la proliferacion celular de los osteoprogenitores son dependientes del estadio de diferenciacion osteoblastica. Tras confirmar su capacidad de diferenciacion in vitro por expresion genica de Runx2 y acumulacion de calcio, se analizo la respuesta proliferativa a estimulos con VEGF o PTHrP(1-36) de ASCs sometidas o no a induccion osteogenica. VEGF pero no PTHrP(1-36) estimulo la capacidad proliferativa de las ASCs no inducidas mientras que PTHrP(1-36), pero no VEGF, estimulo la proliferacion de las ASCs inducidas, corroborando el papel diferencial de estos factores de crecimiento en distintos estadios de diferenciacion. EnglishAdipose tissue contains a large number of mesenchymal stem cells (ASCs) residing in their vascular stroma. Although there is controversy regarding the ability to generate bone tissue from these cells in vivo, the in vitro cells offer a good model of osteogenic differentiation due to its phenotypic similarity with the bone marrow stromal cells (BMSCs) in culture. The differentiation of osteo-progenitor populations of bone marrow is intensely regulated by local factors, such as vascular endothelial growth factor (VEGF) and parathyroid hormone-related protein (PTHrP), which modulate these populations' proliferation in different stages of differentiation. Both the VEGF and the N-terminal fragment of the PTHrP exert osteogenic effects. In this study, we posited that its effects on proliferation of osteo-progenitors are stage dependent of osteoblastic differentiation. After confirming its capacity to in vitro differentiation by Runx2 gene expression and accumulation of calcium, the proliferative response to stimuli was analyzed with VEGF or PTHrP (1-36) of ASCs submitted or not to osteogenic induction. VEGF, but not PTHrP (1- 36), stimulated the proliferative capacity of uninduced ASCs, whereas BMSCs, but not VEGF, stimulated the proliferation of induced ASCs, corroborating the differential role of this growth in different stages of differentiation.
Computer guided algorithm for segmental mandibular resection and titanium plate reconstruction

Aim: The aim of this study was to introduce and assess a new computer guided algorithm using locating holes and cutting guides, for mandibular segmental resection in cases with massive contour deformity. Patients and Methods: This was a prospective study conducted on 6 consecutive cases with mandibular odontogenic neoplasms indicating lateral segmental mandibular resection. For all the patients, computer guided resection and titanium plate reconstruction using locating holes and cutting guides was performed. The patients were followed up for 6 months; and recurrence, appearance, occlusion, maximum incisal opening (MIO), midline shift, chewing, swallowing, speech, pain were recorded. Results: No recurrence occurred in the study till the end of follow up period. 33.3 % of the observed minor change in appearance, and 66.7 % observed no appearance change. No major disruption in occlusion occurred for any patient. The mean MIO was 41.8 ± 4.35 mm after 1 month, 42.3 ± 3.98 mm after 6 months, with no statistically significant difference. Chewing, swallowing, and speech were as normal for 5 patients (83.3 %). Conclusions: The computer guided resection and titanium plate reconstruction using locating holes and cutting guides was found to be beneficial with promising results regarding function and aesthetics, we recommend the use of this technique for initial resection and reconstruction in delayed grafting. Yet, its use as a definitive reconstruction should be subjected to longer follow up period studies.
From Categories to Homotopy Theory

Category theory provides structure for the mathematical world and is seen everywhere in modern mathematics. With this book, the author bridges the gap between pure category theory and its numerous applications in homotopy theory, providing the necessary background information to make the subject accessible to graduate students or researchers with a background in algebraic topology and algebra. The reader is first introduced to category theory, starting with basic definitions and concepts before progressing to more advanced themes. Concrete examples and exercises illustrate the topics, ranging from colimits to constructions such as the Day convolution product. Part II covers important applications of category theory, giving a thorough introduction to simplicial objects including an account of quasi-categories and Segal sets. Diagram categories play a central role throughout the book, giving rise to models of iterated loop spaces, and feature prominently in functor homology and homology of small categories.
Targeted lipidomics reveals changes in N-acyl serines by acute exposure to an electric field: Molecular insights into the docking of N-18:1 serine interaction with TRPV1 or PPAR-α

Alternative therapy with medical devices using high-voltage electric potential (HELP) to generate an electric field (EF) is common in Japan. However, the mechanisms underlying potential health benefits of this therapy remain unclear. Therefore, we investigated the effect of HELP exposure (9 kV /electrode + 9 kV/electrode, 30 min) on N-acyl serines (N-acyl SERs) using selected reaction monitoring (SRM) analysis in plasma samples obtained from healthy human subjects before and after a single treatment session. N-18:1 SER, and N-16:0 SER were significantly upregulated following HELP exposure. Under these conditions, HELP exposure did not exert on levels of N-18:0 SER, N-18:2 SER, N-20:4 SER, and N-22:6 SER. Because N-18:1 ethanolamine (N-18:1 EA) is known to activate, transient receptor potential vanilloid 1 (TRPV1) and peroxisome proliferator-activated receptor-alpha (PPAR-α), we further examined an in silico docking simulation with TRPV1 and PPAR-α. The binding energies with TRPV1 were -6.359 and -6.227 kcal/mol for N-18:1 SER and N-18:1 EA, respectively. The binding energies with PPAR-α were -7.366 and -6.956 kcal/mol for N-18:1 SER and N-18:1 EA, respectively. In human HepG2 cells, N-18:1 SER enhanced fatty acid-binding protein 1 (FABP1) mRNA expression. N-18:1 SER-induced FABP1 mRNA expression was sensitive to the PPAR-α antagonist GW6471. Our findings provide new insights into the molecular mechanisms of the health benefits of EF therapy. Abbreviations: ACOX1: peroxisomal acyl-coenzyme A oxidase 1; DSPS: delayed sleep phase syndrome; EC50: half maximal effective concentration; EF: electric field; FA: fatty acid; FABP1: fatty acid-binding protein 1; HELP: high-voltage electric potential; HODE: hydroxyoctadecadienoic acid; IL: interleukin; MSL: multiple benign symmetric lipomatosis; N-18:2 EA: N-linoleoyl ethanolamine; N-18:1 EA: N-oleoyl ethanolamine; N-16:0 EA: N-palmitoyl ethanolamine; N-18:0 EA: Nstearoyl ethanolamine; NF-κB: nuclear factor-kappa B; NLRP3: nodlike receptor protein 3; N-20:4 SER: N-arachidonyl serine; N-22:6 SER: N-docosahexaenoyl serine; N-18:2 SER: N-linoleoyl serine; N-18:1 SER: N-oleoyl serine; N-16:0 SER: N-palmitoyl serine; N-18:0 SER: N-stearoyl serine; PLAAT: phospholipase A/acyltransferase; PLA2: phospholipase A2; PPAR-α: peroxisome proliferator-activated receptoralpha; qRT-PCR: quantitative real-time polymerase chain reaction; SRM: selected reaction monitoring; TLR4: toll-like receptor 4; TRPV1: transient receptor potential vanilloid 1.
Complex Modeling and Design of Catalytic Reactors Using Multiscale Approach - Part 1: Diffusion in Porous Catalyst

The presented work is dedicated to the modeling of catalytic reactors using a multiscale approach, based on the combination of cellular automata and Computational Fluid Dynamics (CFD). This work describes the first step in the development of a complex model of catalytic reactors and considers the diffusion of components inside a porous structure of an aluminosilicate catalyst. Various cellular automata were used to generate virtual porous structures of catalysts with specific surface areas equal to 250, 500, and 700 m2/g and to calculate the effective diffusion coefficient for the substance transfer inside the catalysts. The obtained effective diffusion coefficient was included in the CFD model of a laboratory scale reactor simulating extraction of aniline from the catalyst with methanol. Results of numerical experiments carried out using the CFD model were compared with the corresponding experimental data. It is shown that the proposed approach is suitable for describing macroscopic and microscopic mass transfer phenomena on consideration of the catalyst’s structure.
Urinary Tract Infection in Children: Diagnostic and Prognostic Utility of Biomarkers

In the diagnostic evaluation of urinary tract infection (UTI) in children, dipstick urinalysis and urine microscopy/culture are the initial steps. Although these investigations are not without their drawbacks, urine culture remains the gold standard. Biomarkers may also be used as diagnostic tools, predictors of complications, and renal parenchymal injury. This paper aims to review the studiesreportingtheutilityof biomarkersinthediagnosisandprognosticationof UTI.Usingthekeywords-‘urinarytractinfection’, ‘children’, and ‘biomarkers’- the PubMed database was searched for systematic reviews/meta-analyses and original studies, which werepublishedwithinthepast25years. Informationwasalsogatheredfromrelevanttextbookspublishedwithinthesameperiod. Serumprocalcitonin,urine/seruminterleukin6(IL-6)and8(IL-8),aswellasurineneutrophilgelatinase-associatedlipocalin(NGAL) are the major biomarkers of febrile UTI. In addition, procalcitonin and these cytokines are reported to be early predictors of vesico-uretericreﬂux(VUR)andrenalparenchymalinjury,whileprocalcitoninandIL-6canalsohelptodiﬀerentiatebetweenlowerUTIand upper UTI (pyelonephritis). Despite the wide range in the sensitivity and speciﬁcity of these biomarkers reported in the reviewed studies, the values are still acceptable. Some of these biomarkers may, in the future, obviate the need for invasive radiological tests, although their utility still require validation by further research. However, given the ability of imaging studies to detect structural abnormalities of the urinary tract, their use still remains relevant in the investigation of UTI despite the radiation risks associated with majority of them.
Hope, Coping Style, and Dietary Behaviors of Early and Late Postgastrectomy Stomach Cancer Patients

Stomach cancer is the second leading cause of all cancer deaths worldwide and will increase yearly as the population increases (Lambert, 2000). Psychosocial interventions to promote optimal adaptation to stomach cancer and the special circumstances of gastrectomy should be guided by research on personality characteristics, other psychological factors and the health behaviors which characterize phases of recovery. Although coping styles of gastrectomy patients had been examined in an earlier study, no study had been conducted from a biopsychosocial perspective. In the present study, a group of stomach cancer patients ( 15) surviving less than five years postsurgery were compared to a group of stomach cancer patients (10) surviving five or more years postsurgery on personality traits of goal-based hope, coping style, knowledge about cancer, quality of life, and health-related behaviors. Findings revealed that early phase survivors used a predominant coping style of anxious preoccupation, whereas long term survivors used a predominant style of fatalism. Both early and late survivors reported an average quality of life which was positively associated with goal-oriented hope, the coping style fatalism, and negatively associated with the coping style hopelessness/ helplessness. Long term stomach cancer survivors are at special risk for nutrient deficiencies that can lead to severe muscle wasting, osteoporosis and anemia. Both early and late phase patients consumed deficient levels of calcium, and vitamin D and had a substandard status of Body Mass Index (BMI). The strongest predictive factors for time since surgery for this study population of cancer patients were coping styles of anxious preoccupation, fighting spirit, and cogntitive vi avoidance; BMI; and knowledge about cancer. This study was not designed to measure the influence of factors on survival. It provides a description of patients who were in different phases of postgastrectomy surgery and offers suggestions as to how the findings can be used by clinicians to select appropriate interventions. Chapter
Synthesis, Theoretical and Antimicrobial Activity Study of New Benzimidazole Derivatives

Abstract A variety of synthetic routes to benzimidazole derivatives have been reported based on different heterocyclic rings such as Schiff bases, 2-azetidinone, 4-thiazolidinone and 1,3-oxazepan. Additionally, HOMO-LUMO and vibrational wavenumbers which represent the quantum mechanical calculations of energies were conducted by Density functional theory (DFT) method at the level of B3LYP with 6-31G(d,p) basis set. FTIR, ¹H NMR spectroscopy and spectral mass spectrometry were used to characterize these compounds; this was followed by measuring the biological activities for gram-negative, gram-positive bacteria and fungi by using diffusion protocol. The outcomes of DFT calculations showed consistency between the experimental values and theoretical of the vibrational and NMR spectroscopy.
DIAGNOSIS OF PREGNANCY AND TWINNING IN MOOSE BY ULTRASONOGRAPHY AND SERUM ASSAY

We evaluated transrectal ultrasonography and serum assay for detecting pregnancy in captive and wild moose (Alces a/ces). Ultrasonographic determination of twinning appeared most feasible during days 30-80 of gestation (4 November- 24 December). During December, January, and March, pregnancy, but not twinning, was reliably detected ultrasonographically; diagnosis was confirmed by the presence of a fetus or placentomes. In addition, serum was assayed for pregnancy­ specific protein B (PSPB). During December, January, and March, both techniques were 100% accurate in diagnosing pregnancy. However, accuracy of diagnosis during November was 95% and 90% by ultrasound and PSPB assay, respectively, based on our assumption that false positives did not occur with ultrasonography. Detection of the presence of a conceptus in utero eliminates calf detection biases associated with post-partum assessment of moose population productivity.
Effects of Water Deficit on Growth, Biomass Allocation and Photosynthesis of A. senegal Seedlings from Nguru and Gujba Provinces of Yobe State, North Eastern Nigeria

Acacia senegal (L) Willd is a multipurpose tree species that occurs throughout semi-arid Africa. Poor yields of gum from the species in the semi-arid region of Nigeria may be due to more frequent drought events. It is not yet clear whether some populations of A. senegal may respond differently to any encroaching drought. The effects of water deficit on growth, biomass allocation and photosynthesis of A. senegal seedlings from Nguru and Gujba province of Yobe state, North Eastern Nigeria were studied under glasshouse conditions for 120 days. Plants were subjected to three watering regimes; control (well-watered) conditions corresponding to 25% gravimetric water content (GWC), mild water deficit at 15% (GWC) and severe-water-deficit at 10% (GWC), respectively. There was a highly significant difference in stomata conductance among the treatments (F2, 84=11.38, P< 0.001) in relation to water deficit. There was no statistical difference in quantum yield between the two provenances (F1, 84 =0.15, P=0.695) and interaction between treatment and provenances was also not significant (F2, 84= 2.14, P=0.124). mean root length between the provenances were significantly different (F2,84 =0.60, P< 0.001) however Root length was not statistically significant between treatments (F2,84= 0.60, P= 0.550). Plant biomass, stomata conductance, quantum yield, chlorophyll fluorescence, relative water content, root length and root: shoot ratios were highly responsive to changes in soil water. It was concluded that A. senegal is capable of physiological adjustment in response to soil moisture as a form of ecological adaptation.Keywords: biomass allocation, provenances, relative water content, stomata conductance.