Miracle-dz/UniFAR-FTUs huggingface dataset:
The need for individualized studies to compare radiogenic second cancer (RSC) risk in proton versus photon Hodgkin Lymphoma patient treatments

For Hodgkin Lymphoma (HL), proton therapy has been shown to potentially reduce therapeutic dose to healthy tissue and therefore the risk of developing a radiogenic second cancer (RSC) relative to photon therapy. Currently, commercial treatment planning systems (TPS) do not account for stray radiation doses for these treatments and their risks of late effects. Treatment plans were created and therapeutic doses were calculated with commercial TPSs for the breast, lung, and thyroid of nine HL patients. Stray dose contributions were added by thermoluminescent dosimeter (TLD) measurements in an anthropomorphic phantom for the intensity modulated radiation therapy (IMRT) treatments and personalized Monte Carlo simulations for the proton treatments. The mean relative risk (RR) of developing a RSC following HL treatment with proton therapies was then calculated and compared to photon IMRT, and reported with the metric ratio of relative risk (RRR). Results showed generally lower RSC risks after proton therapy than photon IMRT when averaged over all patients in the cohort for the breast (RRR = 0.84±0.03), lung (RRR = 0.77±0.03), and thyroid (RRR = 0.83±0.05), but were not universal across all patients examined. Our findings revealed that it is important to include stray dose contributions when comparing the RSC risks for different HL treatment techniques and demonstrated the importance of personalized dose and risk calculations for modern HL radiotherapy.
Interactive comment on “Stream temperature prediction in ungauged basins: review of recent approaches and description of a new physically-based analytical model” by A. Gallice et al

The referee questions our general statement that the model is physically-based, pointing at the fact that it actually involves regression. We certainly acknowledge this comment and fully agree with the referee. The analytical solution to the heat-balance equation leads to an expression, certain terms of which cannot be readily evaluated. These terms are approximated using linear (and nonlinear) regression expressions of known physiographic properties of the catchments, hereby introducing statistical aspects into the model. Moreover, among the different regression expressions used to approximate each unknown term, the best one is selected using the Akaike information criterion, which is a well-established statistical technique. To answer the referee’s comment, we therefore propose to modify the general tone of the manuscript. For example, we intend to refer to our model as “physics-derived statistical model” instead of “physically-based model” — unless the referee has a better suggestion. We will also remove the assertion that our model avoids the typical limitations of statistical models. More generally, the main message of the article will be changed; it will be presented as investigating the potential gains resulting from the derivation of the structure of a statistical model based on physical considerations.
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF RAMIPRIL HCL AND METOPROLAL TARTRATE IN PURE AND IN COMBINATIONS BY UV SPECTROPHOTOMETRY AND RP-HPLC

Simple, rapid and accurate UV Spectroscopic (Simultaneous Equation method and First order derivative method) and an isocratic RP – HPLC methods showed excellent sensitivity, reproducibility, accuracy, and repeatability. In simultaneous UV method, the overlaid spectra of mixture of Ramipril HCl and Metoprolol Tartrate were recorded. From the spectra, 206nm for Ramipril HCl and 222nm for Metoprolol Tartrate was selected as wavelength to construct simultaneous equation. The percentage label claim present in tablet formulation was found to be 101% and 103% for Ramipril HCl and Metoprolol Tartrate respectively. In second method, the same spectrums were derivatised and 205 nm selected for detection of Ramipril HCl where Metoprolol Tartrate shows zero crossing and also 210 nm selected for detection of Metoprolol Tartrate where Ramipril HCl shows zero crossing. The percentage label claim present in formulation was found to be 98.5% and 101% for Ramipril HCl and Metoprolol Tartrate respectively. In RP-HPLC method, mobile phase used is acetonitrile: methanol: acetate buffer pH 5.0 (30:50:20 V/V) with flow rate of 0.9 ml per min, the retention time of Metoprolol Tartrate and were found to be 2.84 and, 3.55respectively. The percentage purity was found to be 99.76% and 99.82% for Metoprolol Tartrate and Ramipril HCl, respectively. The low % RSD values for recovery indicated that the method was found to be accurate.
Molecular Identification and Phylogenetic Affinity of Two Growth Promoting Fungal Endophytes of Sweet Potato (Ipomea batatas (L.) Lam.) from Baguio City, Philippines

A total of 36 fungal endophytes were isolated from apparently healthy sweet potato plants from leaves, stems and roots collected from Baguio City. Among the isolates, only P3AL2c (GenBank accession no. JN672600.1) and P3BS1c (GenBank accession no. JN672605) significantly enhanced growth of paclobutrazol treated rice seedlings. The genomic DNA of these two fungal endophytes were isolated and ran on PCR using ITS 1 and ITS 4 primers. The PCR products were sequenced and subjected to BLASTn for detection of homology to Genbank accessions. P3AL2c was closest to Fusarium oxysporum isolate UOA/HCPF and P3BS1c was most homologous with Emericella nidulans strain FH5. Phylogenetic analysis using maximum likelihood algorithm with 1000 bootstrap replications generated the phylogenetic affinities of the isolates with Fusarium/Gibberella clade and Emericella nidulans, respectively.
THE LINEAR MODEL FOR THE ROUTINE MAINTENANCE EVALUATION OF EARTHQUAKE RESCUE EQUIPMENTS

The linear model for the routine maintenance evaluation of earthquake rescue equipments is presented. Based on the maintenance data of CISAR rescue equipments in the past five years, the routine maintenance costs is analyzed and the linear model is set up through divide the costs to four parts and their separate statistics. There are both simple linear model and weighted linear model and also the compare of deviation for the two models is there.
Research on Evolutionary Immune Mechanism in KDD

In this paper, we introduce an evolutionary immune method to solve the problems from dynamic data mining. We first present a new concept to describe our specific problem domain. Then, we identify the evolutionary immune mechanism in KDD by illustrating how the elements involved in the domain can be modeled as the ones in an immune model. Accordingly, we describe a dynamic mining algorithm in detail and prove it correct and effective. Finally, we conclude our work and present proposals for future work.
Blood pressure lowering and cardio-protective effects of garlic (Allium sativum) and ginger (Zingiber officinale) extracts in some laboratory animals

This study evaluated the blood pressure effects and cardio-protective function of ginger and garlic extracts in laboratory animals. Wistar rats of both sexes were assigned into the following groups: Group I: Served as control + distilled water; Group II: 20 mg/kg of garlic; Group III: 40 mg/kg of garlic; Group IV: 20 mg/kg of ginger; Group V: 40 mg/kg of ginger; Group VI: garlic 10 mg and ginger 10 mg/kg; Group VII: garlic 20 mg and ginger 20 mg/kg. Animals were euthanized after four weeks of treatment. Blood samples were collected and serum separated for lipid profile assay. The effect of extracts on perfused rabbit heart was also investigated. Moreover, the effect of extract on blood pressure was tested in anaesthetized cats. The results obtained in the study showed a statistically significant decrease (p<0.05) of serum total cholesterol (TC), triglyceride and low density lipoprotein-cholestero (LDL-C) levels at all single and combined doses of the extract when compared with the control group. The extract single and combined doses significantly increased (p<0.05) serum high density lipoprotein-cholesterol (HDL-C) level in the treated animals when compared with the control group. The results showed a significantly decreased rate and force of contraction at the combined doses when compared with the baseline line control level (p<0.05). The study also revealed that the administration of only garlic at dose of 0.1 and 1 mg/ml produced a significant decrease (p<0.05) in the diastolic blood pressure. There was a statistically significant decrease (p<0.05) in diastolic blood pressure in all single doses of garlic as well as the combined doses of garlic and ginger extract administered. The result obtained showed that administration of only single doses of ginger produced a significant decrease in p < 0.05. Administration of single doses of garlic (0.1 and 1 mg/ml) produced significant reduction (P < 0.05) in mean arterial pressure (MAP) when compared with control group. In conclusion, the findings suggest that the extract as well as its combination improved lipid profile and may have a cardio-protective effect. Key words: Garlic, ginger, isolated perfuse heart, total cholesterol, triglyceride, low-density lipoprotein, blood pressure.
Incidence, Associated Clinical Factors and Outcome of Hypertensive Crises in Critically Ill Patients: A Prospective Survey

Background: Hypertensive crises (HCs) are common among critically ill patients. However, little is known of their epidemiology, particularly actual rate and outcome of affected patients. Primary end-point of the study was to assess incidence of and clinical factors associated with HCs in a cohort of patients admitted to a general ICU. Secondary end-point was to assess the impact of HC on patients’ outcome. Methods: All patients consecutively admitted to a general ICU over a 13 months period were included in the study. Incidence of HCs was assessed and associated clinical factors were determined using univariate and multivariate analysis. Length-of-stay and ICU- and in-hospital mortality were evaluated. Results: Incidence of HCs was 15.4%. Factors independently associated with HCs were: ICU-admission for acute medical conditions, cigarette smoking, cancer, coronary artery disease, chronic atrial fibrillation (p<0.05). ICU length-of-stay and ICU-/ in-hospital mortality rate were higher among patients with HCs (p<0.05). Conclusion: HCs are common in critically ill patients, even if previously normotensive, and are associated with a worse outcome. Associated clinical factors include acute medical conditions leading to ICU admission, cigarette smoking, cancer, coronary artery disease and chronic atrial fibrillation.C
Silicon isotopic abundance toward evolved stars and its application for presolar grains

Galactic chemical evolution (GCE) is important for understanding the composition of the present-day interstellar medium (ISM) and of our solar system. In this paper, we aim to track the GCE by using the 29Si/30Si ratios in evolved stars and tentatively relate this to presolar grain composition. We used the APEX telescope to detect thermal SiO isotopologue emission toward four oxygen-rich M-type stars. Together with the data retrieved from the Herschel science archive and from the literature, we were able to obtain the 29Si/30Si ratios for a total of 15 evolved stars inferred from their optically thin 29SiO and 30SiO emission. These stars cover a range of masses and ages, and because they do not significantly alter 29Si/30Si during their lifetimes, they provide excellent probes of the ISM metallicity (or 29Si/30Si ratio) as a function of time. The 29Si/30Si ratios inferred from the thermal SiO emission tend to be lower toward low-mass oxygen-rich stars (e.g., down to about unity for W Hya), and close to an interstellar or solar value of 1.5 for the higher-mass carbon star IRC+10216 and two red supergiants. There is a tentative correlation between the 29Si/30Si ratios and the mass-loss rates of evolved stars, where we take the mass-loss rate as a proxy for the initial stellar mass or current stellar age. This is consistent with the different abundance ratios found in presolar grains. We found that older objects (up to possibly 10 Gyr old) in our sample trace a previous, lower 29Si/30Si value of about 1. Material with this isotopic ratio is present in two subclasses of presolar grains, providing independent evidence of the lower ratio. Therefore, the 29Si/30Si ratio derived from the SiO emission of evolved stars is a useful diagnostic tool for the study of the GCE and presolar grains.
Comment on Elena Giomi and Fabrizio Tonello/1. The boundaries at stake: towards a structural understanding of femicide as moral panic

The article by Elisa Giomi and Fabrizio Tomello is decidedly intriguing and will undoubtedly foster future debates. The authors start from the definition of “moral panic” and the process on which the definition given by Stanley Cohen is rooted [Cohen, 1980]. On the basis of these premises, they address the problem of “proportionality” and try to explain when the attention given by the media to a social issue is disproportionate to its real diffusion and to the real threat it represents. The findings of the study, however, are not convincing and do not provide adequate arguments to answer the starting question for mainly methodological reasons.
Temporal changes in spring migration phenology in the Norwegian Greylag Goose Anser anser, 1971-2004

During spring, Greylag Geese Anser anser migrate from staging grounds in the Netherlands to breeding sites in Norway. The timing of this migration is critical as it corresponds to the most energetically expensive period in the birds’ seasonal cycle, and governs the time available for breeding during the short northern summer. This paper reports how the spring migration and the subsequent breeding season of Greylag Geese nesting in Norway have gradually become earlier since 1971, by about 5–7 days per decade up to 2004. First arrival date, median arrival date and fi rst hatching date at the most important breeding site in Norway were inversely related to spring temperatures in the Netherlands, suggesting that this trend may be a function of climate change.
A Comparison Of Students In Physical Education and Sports College and The Students In Other Departments In Terms Of Problem Solving Skills

In this research, it is aimed to analyze the problem solving skills of university students in terms of different variables and to analyze the differences among the levels of perceived problem solving skill of the students of Physical Education and Sports College and other branch students. The sample consists of the university students from the School of Physical Education and Sports (128) and from the Department of Tourism and Hotel Management (104) from the Faculty of Economics and Administrative Sciences Department (162), summing up 394 students (n female =193, n male =201) in total, based on the simple random sampling method. "Personal Information Form" and "Problem Solving Inventory (PSI)" were used as data collection tools. The T-test and One-Way ANOVA were used for normal distribution and LSD Test was used for determining the differences across groups. When the data were analyzed in terms of the variables of the study, it was found that a significant difference between the gender variable and problem solving skill in favour of males although there was no statistically significant difference between the problem solving skills and the place of birth of the students and the number of family members. It was found a significant difference between the students from School of Physical Education Sports and Department, students from Tourism and Hotel Management Department and students from the Faculty of Economics and Administrative Sciences Department in favour of the students from The Faculty of Economics and Administrative Sciences Department. Based on the findings of the research; Problem-solving skills of the students of the Physical Education and Sports College were found to be lower than the other departments.
Primary Non-Adherence of PrescribedPharmaceutical Treatments and Interventions:An Investigative Review to Improve Quality inPrimary Care

Aim: To review non-disease-specific predictors and causes of primary non-adherence of prescribed pharmaceutical treatments and interventions. Method: A PubMed literature search (up to October 2015) using the terms primary, initial, first-fill and index with terms related to non-initiation, adherence, compliance, redemption and dispensing. The references, citations and similar articles for the identified articles were used to identify additional sources. Study selection and data extraction: Prescription record-based and survey-based studies considering at least four medication classes or diseases while evaluating factors (predictors and causes) associated with primary non-adherence were examined. Results: 53 articles were identified, including 16 specific to cost-related primary non-adherence. Regularly cited factors were age, gender, race and ethnicity, mental health, comorbidities, polypharmacy, medication beliefs, side effects, affordability, education, number of clinic, hospital and emergency department visits, patient-physician relationship, prescriber traits, forgetfulness and convenience. Issues related to affordability were raised most frequently, being brought up in 37of 53 sources. Many of the articles provided conflicting reports as to the direction of predictors and the importance of causes of primary non-adherence. Conclusion: To date, numerous factors have been identified and associated with primary non-adherence to medications. Some factors may appear to be more influential than others, though the relevance of each predictor and cause varied between studies. To date, discrepant data in the literature has prevented the homogeneous analysis of primary adherence to prescribed pharmaceutical treatments. By compiling the factors and barriers related to primary non-adherence, this investigative review will prompt and promote future research in this area. Ultimately, primary care physicians will be better equipped to understand, act and potentially prevent patients from avoiding treatment regimes at the outset.
The Application of Bayesian Classification Theories in Distance Education System

With the vigorous application of distance education in recent years, the biggest challenge that the learners and managers are facing today is how to institute the training courses and choose the learning resources according to the personal characteristics of learners. It is subjective to arbitrarily decide the learning resources. This study presents a new constructional method, based on the Bayesian networks of courses relationship. This method uses the feedback of learning resources from the learners and examination results of training courses as data samples. And a new procedure is presented, joining quantitative value of RFM model and naive Bayesian algorithm, to classify the learners and offer more support to make decision. Moreover, the experimental results demonstrate that the algorithm is efficient and accurate, and the Bayesian network method can be used in other Electronic Commerce System Index Terms—Bayesian networks; naive Bayesian; classification; distance education; RFM model
THE TRANSIT LIGHT-CURVE PROJECT. XIV. CONFIRMATION OF ANOMALOUS RADII FOR THE EXOPLANETS TrES-4b, HAT-P-3b, AND WASP-12b

We present transit photometry of three exoplanets, TrES-4b, HAT-P-3b, and WASP-12b, allowing for refined estimates of the systems’ parameters. TrES-4b and WASP-12b were confirmed to be “bloated” planets, with radii of 1.706 ± 0.056RJup and 1.736 ± 0.092RJup, respectively. These planets are too large to be explained with standard models of gas giant planets. In contrast, HAT-P-3b has a radius of 0.827 ± 0.055RJup, smaller than a pure hydrogen–helium planet and indicative of a highly metal-enriched composition. Analyses of the transit timings revealed no significant departures from strict periodicity. For TrES-4, our relatively recent observations allow for improvement in the orbital ephemerides, which is useful for planning future observations.
INFLUENCE OF EXOGENOUSLY APPLIED SALICYLIC ACID AND PLANT GROWTH PROMOTING RHIZOBACTERIA INOCULATION ON THE GROWTH AND PHYSIOLOGY OF SUNFLOWER (HELIANTHUS ANNUUS L.) UNDER SALT STRESS

Present attempt is to evaluate the effect of Salicylic acid (SA) alone and in combination with plant growth promoting rhizobacteria (Azospirillum and Pseudomonas) on sunflower plant under salt stress. Two hybrids of sunflower were inoculated with Azospirillum spp. and Pseudomonas spp. applied as seed soaking treatment prior to sowing. Salt stress (20dSm -1 ) was induced 28d after sowing. Foliar application of Salicylic acid (10 -4 M) was made 4h after induction of salt stress. The osmotic potential, antioxidants (SOD, POD) analyses were made from the plant leaves. Salicylic acid application alone and in combination with Azospirillum and Pseudomonas minimized the inhibitory effects of salt stress. The survival efficiency of Azospirillum and Pseudomonas under salt stress in the presence of Salicylic acid was higher as compared to salt treatment made alone. The salt tolerance in these treatments was mediated by increase in the superoxide dismutase and peroxidase activities in leaves of sunflower and increase in growth of sunflower hybrids. The adverse effects of salt stress could be alleviated by foliar application of Salicylic acid used alone and more effectively in combination with Azospirillum and Pseudomonas inoculations.
Induction of hepatic lipogenic gene expression upon pharmacological inhibition of glucose-6-phosphate translocase is independent of liver X receptor alpha Chapter 7

In mammals, hepatic expression of lipogenic genes is regulated by the coordinate action of thetranscription factors sterol-regulatory element-binding protein-1c (SREBP-1c), carbohydrate responsive element binding protein (ChREBP) and liver X receptor (LXR). The “master-switch” LXR controls not only transcription of Srebp-1c and Chrebp but also ChREBP activity. Treatment of mice with S4048, a pharmacological inhibitor of glucose-6phosphate translocase, results in increased hepatic triglyceride concentrations associated with markedly enhanced transcription of lipogenic genes. We used C57BL/6J OlaHsd mice as well as LXRα -/mice and their wild-type littermates to investigate which lipogenic transcription factor is critical for S4048-induced de novo lipogenesis and hepatic steatosis. S4048-treatment resulted in similar induction of hepatic steatosis and lipogenic gene expression in all strains of mice, i.e., does not require the presence of LXRα. Expression of the ChREBP target gene pyruvate kinase was significantly increased, but expression of Srebp-1c and its target gene glucokinase was not affected or even decreased by S4048. Nuclear translocation of ChREBP was not affected, probably related to concomitantly increased AMPK activity. These data strongly indicate involvement of ChREBP but not of SREBP-1c and LXRα in S4048-induced de novo lipogenesis and hepatic steatosis.
Full Reference Image Quality Assessment of Perceptual Distortion based on Image Retargeting

Image quality assessment is used for automatic evaluation of the image accurately. In this article, objective reference image quality assessment metric is used to evaluate the quality of retargeted images. The metric measures perceptual geometric distortion and information loss of retargeted images using deformable spatial pyramid (DSP) algorithm. NRID and RetargetMe database are employed to measure the performance of the metric. Experimental results shows that the performance of DSP algorithm is superior thanScale-invariant feature transform (SIFT) in terms of runtime and accuracy. Image retargeting, fast dense correspondence, Image quality assessment, deformable spatial pyramid, full reference image quality assessment