Miracle-dz/UniFAR-FTUs huggingface dataset:
Problems Perceived by Skilled Nurses regarding the Independence of Children with Congenital Heart Disease

ABSTRACT This study was conducted to determine how skilled nurses perceive the independence of children with congenital heart disease. A questionnaire survey was administered to elicit responses to questions such as whether the skilled nurses noticed problems with the independence of children with congenital heart disease, and whether they thought that support from adults close to the children was needed to foster independence. More than 60% of the 84 nurses perceived problems regarding the independence of children with congenital heart disease. Situations in which skilled nurses noticed problems, in addition to difficulties and limitations in understanding of the disease, included instances of family members making decisions and answering questions and of the child being unable to communicate easily. Nearly all of the skilled nurses felt that support from adults close to children with congenital heart disease was needed to foster their independence.
Sleep Behaviors in Persons With Alzheimer’s Disease: Associations With Caregiver Sleep and Affect

Poor sleep in persons with Alzheimer’s disease (AD) is a common stressor for family caregivers. Retrospective reports support associations between sleep disturbance in persons with AD and worse caregiver mood; however, prospective associations between sleep in persons with AD and caregiver outcomes have not been studied. The current study determined associations between affect and sleep of persons with AD and their caregivers using daily diary data. Multilevel mediation models indicated that sleep in persons with AD is linked to caregiver affect; furthermore, these associations are mediated by sleep characteristics in caregivers and affect in persons with AD. Daily fluctuations in sleep behaviors in persons with AD—rather than average values—were most strongly associated with caregiver outcomes. Interventions to improve sleep in persons with AD may decrease their negative affect and improve caregiver mood.
BRD9 Is a Critical Regulator of Androgen Receptor Signaling and Prostate Cancer Progression

Advanced prostate cancers resistant to androgen receptor antagonists are still susceptible to nontoxic BRD9 inhibitors, making them a promising alternative for halting AR signaling in progressed disease. Switch/sucrose-nonfermentable (SWI/SNF) chromatin-remodeling complexes are critical regulators of chromatin dynamics during transcription, DNA replication, and DNA repair. A recently identified SWI/SNF subcomplex termed GLTSCR1/1L-BAF (GBAF; or “noncanonical BAF”, ncBAF) uniquely contains bromodomain-containing protein BRD9 and glioma tumor suppressor candidate region 1 (GLTSCR1) or its paralog GLTSCR1-like (GLTSCR1L). Recent studies have identified a unique dependency on GBAF (ncBAF) complexes in synovial sarcoma and malignant rhabdoid tumors, both of which possess aberrations in canonical BAF (cBAF) and Polybromo-BAF (PBAF) complexes. Dependencies on GBAF in malignancies without SWI/SNF aberrations, however, are less defined. Here, we show that GBAF, particularly its BRD9 subunit, is required for the viability of prostate cancer cell lines in vitro and for optimal xenograft tumor growth in vivo. BRD9 interacts with androgen receptor (AR) and CCCTC-binding factor (CTCF), and modulates AR-dependent gene expression. The GBAF complex exhibits overlapping genome localization and transcriptional targets as bromodomain and extraterminal domain–containing (BET) proteins, which are established AR coregulators. Our results demonstrate that GBAF is critical for coordinating SWI/SNF–BET cooperation and uncover a new druggable target for AR-positive prostate cancers, including those resistant to androgen deprivation or antiandrogen therapies. Significance: Advanced prostate cancers resistant to androgen receptor antagonists are still susceptible to nontoxic BRD9 inhibitors, making them a promising alternative for halting AR signaling in progressed disease.
Translation and Psychometric Evaluation of the German Version of the Thirst Distress Scale for Patients With Heart Failure

Background In patients with chronic heart failure, thirst can be perceived as an intensive and burdensome symptom, which may have a negative impact on patients' quality of life. To initiate thirst-relieving interventions, assessment of thirst and its related distress is essential. At the time of this study, no instrument was available to evaluate thirst distress in patients with heart failure in Germany. Objective The aims of this study were to translate the “Thirst Distress Scale for patients with Heart Failure” (TDS-HF) from English into German and to test validity and reliability of the scale. Methods The English version of the TDS-HF was translated into German. A linguistically and culturally sensitive forward-and-backward translation was performed. Psychometric evaluation included confirmatory factor analysis, reliability in terms of internal consistency, and concurrent validity. Results Eighty-four hospitalized patients (mean age, 72 ± 10 years; 29% female; mean left ventricular ejection fraction, 36% ± 12%; 62% New York Heart Association functional classes III–IV, 45% on fluid restriction) from an acute care hospital were involved in the study. The item-total correlation ranged from 0.58 to 0.78. Interitem correlations varied between 0.37 and 0.79. Internal consistency was high, with a Cronbach α of 0.89. There was a high correlation between the total score of the TDS-HF and the visual analog scale to assess thirst intensity (r = 0.72, P ≤ .001), and a low correlation with fluid restriction (r = 0.35, P = .002). Conclusions The evaluation of the German TDS-HF showed satisfactory psychometric properties in this sample. The instrument is usable for further research and additional psychometric testing.
After-Hours/Nighttime Transfers Out of the Intensive Care Unit and Patient Outcomes: A Systematic Review and Meta-Analysis

Purpose: We evaluated the effects of after-hours/nighttime patient transfers out of the ICU on patient outcomes, by performing a systematic review and meta-analysis (PROSPERO CRD 42017074082). Data Sources: MEDLINE, PubMed, EMBASE, Google Scholar, CINAHL, and the Cochrane Library from 1987-November 2019. Conference abstracts from the Society of Critical Care Medicine, American Thoracic Society, CHEST, Critical Care Canada Forum, and European Society of Intensive Care Medicine from 2011-2019. Data Extraction: Observational or randomized studies of adult ICU patients were selected if they compared after-hours transfer out of the ICU to daytime transfer on patient outcomes. Case reports, case series, letters, and reviews were excluded. Study year, country, design, co-variates for adjustment, definitions of after-hours, mortality rates, ICU readmission rates, and hospital length of stay (LOS) were extracted. Data Synthesis: We identified 3,398 studies. Thirty-one observational studies (1,418,924 patients) were selected for the systematic review and meta-analysis. Included studies had varying definitions of after-hours, with the after-hours period starting anytime between 16:00-22:00 and ending between 06:00-09:00. Approximately 16% of transfers occurred after-hours. After-hours transfers were associated with increased in-hospital mortality for both unadjusted (odds ratio [OR] 1.51, 95% confidence interval [CI] 1.30-1.75, I2 = 96%, number of studies [n] = 26, P < 0.001, low certainty) and adjusted (OR 1.32, 95% CI 1.25-1.38, I 2 = 33%, n = 10, P < 0.001, low certainty) data, compared to daytime transfers. They were also associated with increased ICU readmission (pooled unadjusted OR 1.28, 95% CI 1.18-1.38, I2 = 85%, n = 17, P < 0.001, low certainty) and longer hospital LOS (standardized mean difference 0.13, 95% CI 0.09-0.18, I 2 = 93%, n = 9, P < 0.001, low certainty), compared to daytime transfers. Conclusions: After-hours transfers out of the ICU are associated with increased in-hospital mortality, ICU readmission, and hospital LOS, across many settings. While the certainty of evidence is low, future research is needed to reduce the number and effects of after-hours transfers.
Development of a Unique Mouse Intervertebral Disc Degeneration Model Using a Simple Novel Tool

Study Design Animal case control study. Purpose To create a simple, reproducible disc degeneration model for mouse coccygeal vertebrae. Overview of Literature Back pain due to disc degeneration is probably the most common problem encountered in neurosurgical practice. An easily reproducible animal model for disc degeneration will help in understanding its pathophysiology, and serve as a platform for examining various therapeutic options. Methods A total of 18 mice were divided into injured (n=12) and non-injured (n=6) groups. The disc height index (DHI%) at coccygeal 4–5 level was measured by computed tomography (CT) scan for all mice. Coccygeal 4–5 discs of the injury group were injured using a 32G needle fixed to a novel tool and confirmed by CT. The non-injury group underwent no procedure. DHI% was measured by CT at 2-, 4-, and 6-week post-injury, and all mice tails were sectioned for histopathology grading of disc degeneration at the respective time intervals. Results The injured group showed significant variation in DHI% at 2, 4, and 6 weeks, whereas there was no change in the non-injured group. Histopathologic evaluation with Safranin O stain showed a worsening of the disc degeneration score at 2, 4, and 6 weeks in the injured group, but in the non-injured group there was no change. Percutaneous needle injury technique with our novel tool provided 100% accuracy and uniform degeneration. Conclusions A simple, easily reproducible mouse model for disc degeneration was created using a simple, cost-effective, novel tool and technique, its advantage being high precision and user friendly.
Behavioral Deficits and Brain α-Synuclein and Phosphorylated Serine-129 α-Synuclein in Male and Female Mice Overexpressing Human α-Synuclein.

BACKGROUND Alpha-synuclein (α-syn) is a molecule involved in pathology of Parkinson's disease, and 90%of α-syn in Lewy bodies is phosphorylated at serine 129 (pS129 α-syn). OBJECTIVE To assess motor and non-motor behaviors in male and female mice overexpressing human α-syn under Thy1 promoter (Thy1-α-syn) and wild type (wt) littermates. METHODS Motor and non-motor behaviors brain human α-syn levels by ELISA, and mapped α-syn and pS129 α-syn in the brain by immunohistochemistry. RESULTS Male and female wt littermates did not show differences in the behavioral tests. Male Thy1-α-syn mice displayed more severe impairments than female counterparts in cotton nesting, pole tests, adhesive removal, finding buried food, and marble burying. Concentrations of human α-syn in the olfactory regions, cortex, nigrostriatal system, and dorsal medulla were significantly increased in Thy1-α-syn mice, higher in males than females. Immunoreactivity of α-syn was not simply increased in Thy1-α-syn mice but had altered localization in somas and fibers in a few brain areas. Abundant pS129 α-syn existed in many brain areas of Thy1-α-syn mice, while there was none or only a small amount in a few brain regions of wt mice. The substantia nigra, olfactory regions, amygdala, lateral parabrachial nucleus, and dorsal vagal complex displayed different distribution patterns between wt and transgenic mice, but not between sexes. CONCLUSION The severer abnormal behaviors in male than female Thy1-α-syn mice may be related to higher brain levels of human α-syn, in the absence of sex differences in the altered brain immunoreactivity patterns of α-syn and pS129 α-syn.
Effect of Ca doping on the structure and scintillation properties of ZnWO4

The future application of ZnWO4 scintillator in a cryogenic search for rare events is the motivation for optimization of this material. We present results on the effect of Ca doping on the structure and scintillation properties of ZnWO4. X‐ray diffraction analysis revealed that there is no mixing in the CaWO4–ZnWO4 pseudobinary system due to a significant mismatch of the crystal structures of CaWO4 and ZnWO4. The lattice parameters of Ca‐doped ZnWO4 samples obtained from X‐ray powder diffraction data confirmed this finding. It is also shown that ZnWO4 retains the monoclinic wolframite structure when cooling, at 12 K exhibiting the following lattice parameters: a = 4.6826(2) Å, b = 5.7088(2) Å, c = 4.9230(2) Å and β = 90.541(2)°. The scintillation light yield of the Zn1−x Cax WO4 was measured using the multi‐photon counting technique and it is found that small concentrations of Ca (x = 0.001 – 0.02) cause no deterioration of this parameter. Ca doping of ZnWO4 is expected to facilitate production of a single‐crystalline scintillator. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Seasonal Changes in Chemical Composition and Quality Parameters in Capelin (Mallotus villosus)

Abstract Seasonal variation in capelin was examined by measuring chemical and lipid composition, including anti- and pro-oxidants. Lipid oxidation and other deterioration products were monitored. Results on chemical changes during landing of whole capelin indicated that the spoilage processes were intensive. This was evident by decomposition of endogenous antioxidants and gradual onset of rancidity and spoilage. Capelin from each season was found to have some distinctive chemical characteristics. High autolytic activity as well as high content of astax-anthin was found in the heavily feeding summer capelin. Autumn capelin contained the highest lipid content and the lowest stability towards lipid oxidation. The most uniform quality was observed in the winter capelin, while the spawning, fat depleted spring capelin contained the highest content of tocopherols.
“Mental Health” as Defined by Twitter: Frames, Emotions, Stigma

ABSTRACT This study analyzes the general public’s framing of ‘mental health’ and critically assesses the implications of these findings. A mismatch between how people think about mental health and what messages are used in mental health campaigns may hinder attempts to improve mental health awareness and reduce stigma. We have conducted frame analysis by using a combination of topic modeling and sentiment analysis, examining 10 years of mental health-related tweets (n = 695,414). The results reveal seven distinctive mental health frames: ‘Awareness’, ‘Feelings and Problematization’, ‘Classification’, ‘Accessibility and Funding’, ‘Stigma’, ‘Service’, and ‘Youth’ (arranged by salience). In analyzing these frames, we have learned that (1) the general awareness about mental health relates to mental illness, while health and well-being framing, although present, is prone to low quality of information, (2) mental health discourse is often used to problematize social issues and externalize personal anxieties, which tends toward trivialization and, possibly, treatment delays, (3) mental health discourse often revolves around popularized mental illness (e.g., depression, anxiety, but not neurocognitive diseases), (4) the mental health ‘Stigma’ frame is not overly pronounced; it revolves around violence, fear, and madness, (5) mental health is frequently politicized, especially concerning gun laws in the US and service accessibility and funding in the UK. Additionally, some narrower frames discovered may warrant further examination. For instance, PTSD is mostly framed around veterans and suicide, ADHD around youth, and substance abuse in relation to women, teens, and impoverished.
13.56 MHz Triple Mode Rectifier Circuit With Extended Coupling Range for Wirelessly Powered Implantable Medical Devices

In this work, a wide input/output range triple mode rectifier circuit operating at 13.56 MHz is implemented to power up medical implants. The proposed novel multi-mode rectifier circuit charges the load for an extended coupling range and eliminates the requirement of alignment magnets. The charging process is achieved in three different modes based on the voltage level of the received signal affected by the distance and the alignment of the inductively coupled coils. Current mode (CM) circuit is activated for loosely coupled coils whereas voltage mode (VM) rectification is proposed for high coupling ratios. Extended coupling range is covered with the activation of half wave rectification mode (HWM) in between CM and VM. The rectifier circuit utilizes these three modes in a single circuit operating at 13.56 MHz according to the receiver signal voltage. The circuit is implemented in TSMC 180 nm BCD technology with 0.9 mm2 active area and tested with printed coils. According to the measurements, the circuit operates in the received power range of 4 to 57.7 mW, which corresponds to 0.10–0.42 coupling range. The maximum power conversion efficiency (PCE) of each operation mode is 51.78%, 82.49%, and 89.34% for CM, HWM, and VM, respectively, while charging a 3.3 V load.
Bioinformatics analysis identifies potential diagnostic signatures for coronary artery disease

Background Coronary artery disease (CAD) is the leading cause of mortality worldwide. We aimed to screen out potential gene signatures and construct a diagnostic model for CAD. Method We downloaded two mRNA profiles, GSE66360 and GSE60993, and performed analyses of differential expression, gene ontology terms, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. The STRING database was used to identify protein–protein interactions (PPI). PPI network visualization and screening out of key genes were performed using Cytoscape software. Finally, a diagnostic model was constructed. Results A total of 2127 differentially expressed genes (DEGs) were identified in GSE66360, and 527 DEGs in GSE60993. Of the 153 DEGs from both datasets that showed differential expression between CAD patients and controls, 471 biological process terms, 35 cellular component terms, 17 molecular function terms, and 49 KEGG pathways were significantly enriched. The top 20 key genes in the PPI network were identified, and a diagnostic model constructed from five optimal genes that could efficiently separate CAD patients from controls. Conclusion We identified several potential biomarkers for CAD and built a logistic regression model that will provide a valuable reference for future clinical diagnoses and guide therapeutic strategies.
Zolpidem Versus Trazodone Initiation and the Risk of Fall-Related Fractures among Individuals Receiving Maintenance Hemodialysis.

BACKGROUND AND OBJECTIVES Zolpidem, a nonbenzodiazepine hypnotic, and trazodone, a sedating antidepressant, are the most common medications used to treat insomnia in the United States. Both drugs have side effect profiles (e.g., drowsiness, dizziness, and cognitive and motor impairment) that can heighten the risk of falls and fractures. Despite widespread zolpidem and trazodone use, little is known about the comparative safety of these medications in patients receiving hemodialysis, a vulnerable population with an exceedingly high fracture rate. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Using data from the United States Renal Data System registry (2013-2016), we conducted a retrospective cohort study to investigate the association between the initiation of zolpidem versus trazodone therapy and the 30-day risk of hospitalized fall-related fractures among Medicare-enrolled patients receiving maintenance hemodialysis. We used an active comparator new-user design and estimated 30-day inverse probability of treatment-weighted hazard ratios and risk differences. We treated death as a competing event. RESULTS A total of 31,055 patients were included: 18,941 zolpidem initiators (61%) and 12,114 trazodone initiators (39%). During the 30-day follow-up period, 101 fall-related fractures occurred. Zolpidem versus trazodone initiation was associated with a higher risk of hospitalized fall-related fracture (weighted hazard ratio, 1.71; 95% confidence interval, 1.11 to 2.63; weighted risk difference, 0.17%; 95% confidence interval, 0.07% to 0.29%). This association was more pronounced among individuals prescribed higher zolpidem doses (hazard ratio, 1.85; 95% confidence interval, 1.10 to 3.01; and risk difference, 0.20%; 95% confidence interval, 0.04% to 0.38% for higher-dose zolpidem versus trazodone; and hazard ratio, 1.60; 95% confidence interval, 1.01 to 2.55 and risk difference, 0.14%; 95% confidence interval, 0.03% to 0.27% for lower-dose zolpidem versus trazodone). Sensitivity analyses using longer follow-up durations yielded similar results. CONCLUSIONS Among individuals receiving maintenance hemodialysis, zolpidem initiators had a higher risk of hospitalized fall-related fracture compared with trazodone initiators. PODCAST This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2020_12_18_CJN10070620_final. mp3.
Association Between Communicative Participation and Psychosocial Factors in Patients With Voice Disorders.

Importance Communicative participation can be conceptualized as taking part in life situations in which people are socially engaged. Communicative participation is an important aspect in the lives of patients with voice disorders, although it has not been formally assessed among a broad sample of patients with voice disorders. The associations between communicative participation and associated concepts (vocal impairment, psychosocial distress, and voice-specific perceived control) are unknown yet important for integrated treatment approaches. Objective The primary objective was to examine the associations between communicative participation and vocal impairment, psychosocial distress, and voice-specific perceived control. The secondary objective was to examine whether perceived control moderates the association of distress with communicative participation and vocal impairment, the latter of which would replicate previous research. The hypotheses were that communicative participation would be associated with lower vocal impairment, lower distress, and higher perceived control and that higher perceived control would moderate the association between communicative participation and both vocal impairment and psychosocial distress. Design, Setting, and Participants This cross-sectional study was conducted from June 2014 to May 2017 among a consecutive sample of adult patients with voice disorders at an academic voice clinic affiliated with the University of Minnesota. Of the 744 patients approached to participate in the survey study, 590 patients agreed. Data analysis was performed from January to June 2020. Main Outcomes and Measures Communicative participation (measured by the 10-item general short form of the Communicative Participation Item Bank), vocal impairment (measured by the 10-item version of the Voice Handicap Index), psychosocial distress (measured by the 18-item version of the Brief Symptom Inventory), and voice-specific perceived control (measured by the 8-item present control subscale of the Perceived Control Over Stressful Events Scale). Results The sample comprised 590 patients (mean [SD] age, 51.9 [17.1] years; 390 women [66.1%]) with voice disorders. Communicative participation was associated with lower vocal impairment (r = -0.73; 95% CI, -0.77 to -0.69), lower overall psychosocial distress (r = -0.22; 95% CI, -0.30 to -0.14), and higher voice-specific perceived control (r = 0.30; 95% CI, 0.23-0.37). Moderation analyses indicated that communicative participation was negatively associated with distress at all levels of perceived control and, replicating previous findings, greater vocal impairment was associated with higher psychosocial distress only in patients with lower perceived control. Conclusions and Relevance In this study, communicative participation was associated with, but distinct from, vocal impairment and was also associated with psychosocial distress and voice-specific perceived control. The study's results suggest that communicative participation is an important addition to voice research and clinical care.