Miracle-dz/UniFAR-FTUs huggingface dataset:
The impact of COVID-19 restrictions and care home strategies on residents with dementia as experienced by family carers in Italy

Abstract Objectives The COVID-19 pandemic and public health measures caused serious consequences for several population cohorts, including people with dementia in care homes and their families. The aim of this study was to explore the impact of COVID-19 on care home residents with dementia as experienced by family carers in Italy. Specifically, strategies implemented to overcome the pandemic’s constraints, their influence upon care, and consequences for everyday life of residents with dementia and carers were investigated. Methods Semi-structured interviews explored participants’ experiences of the pandemic, its restrictions and the services’ status during lockdown. Transcripts were analysed via thematic analysis. Results 26 family carers were interviewed. Three themes emerged: (1) COVID-19 restrictions negatively affected both residents with dementia and family carers, (2) Changing policies in care homes during COVID-19, and (3) Technology use in care homes during COVID-19. COVID-19 restrictions severely affected care home residents with dementia, disrupted their daily living, and accelerated their cognitive decline. Consequently carers’ emotional burdens increased. Care home response strategies (safe visiting and digital solutions) were critical, though they were not enough to compensate for the lack of close in-person contacts. Conclusions Mixed evidence emerged about the feasibility of care home strategies and their associated benefits. To meet arising needs and possible future pandemic waves, there is a need for updated health strategies. These should prioritise a continuity of therapeutic activities and minimize negative effects on residents’ quality of life, whilst incorporating feasible and accessible digital solutions to provide remote communication and psychological support for family carers.
A triple band circular polarized monopole antenna for GNSS/UMTS/LTE

A circularly polarized Y‐shaped monopole antenna with L‐shaped slot loaded ground‐plane is proposed in this letter. The multi‐band operation is achieved due to the resonances of asymmetrical monopole arms as well as the slot in the ground plane. The circular polarization for LTE (band‐7, 2600 MHz) is achieved by using orthogonal and out of phase currents on surface of Y shaped monopole, whereas circular polarization for GNSS and UMTS‐2100 bands is the result of interaction of currents on longer arm of Y shaped monopole and loop currents on ground, which acts as a magnetic monopole. The antenna has been designed and optimised on a low cost FR‐4 epoxy substrate. The proposed antenna exhibits impedance bandwidths of 13.1, 9.7, and 7.4% at the resonant frequencies of 1.57, 2.02, and 2.55 GHz, respectively. At these three resonances, 3 dB axial ratio bandwidths of 3.7, 4.9, and 5.06% are achieved. The antenna has dual sense circular polarization, bidirectional radiation patterns, stable gain and good efficiency in the operating bands. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:298–304, 2017
Competitive ability depends on mating system and ploidy level across Capsella species

Abstract Background and Aims Self-fertilization is often associated with ecological traits corresponding to the ruderal strategy, and selfers are expected to be less competitive than outcrossers, either because of a colonization/competition trade-off or because of the deleterious genetic effects of selfing. Range expansion could reduce further competitive ability while polyploidy could mitigate the effects of selfing. If pollinators are not limited, individual fitness is thus expected to be higher in outcrossers than in selfers and, within selfers, in polyploids than in diploids. Although often proposed in the botanical literature and also suggested by meta-analyses, these predictions have not been directly tested yet. Methods In order to compare fitness and the competitive ability of four Capsella species with a different mating system and ploidy level, we combined two complementary experiments. First, we carried out an experiment outdoors in north-west Greece, i.e. within the range of the obligate outcrossing species, C. grandiflora, where several life history traits were measured under two different disturbance treatments, weeded plots vs. unweeded plots. To better control competition and to remove potential effects of local adaptation of the outcrosser, we also performed a similar competition experiment but under growth chamber conditions. Key Results In the outdoor experiment, disturbance of the environment did not affect the phenotype in any of the four species. For most traits, the obligate outcrossing species performed better than all selfing species. In contrast, polyploids did not survive or reproduce better than diploids. Under controlled conditions, as in the field experiment, the outcrosser had a higher fitness than selfing species and was less affected by competition. Finally, contrary to the outdoor experiment where the two behaved identically, polyploid selfers were less affected by competition than diploid selfes. Conclusions In the Capsella genus, selfing induces lower fitness than outcrossing and can also reduce competitive ability. The effect of polyploidy is, however, unclear. These results highlight the possible roles of ecological context in the evolution of selfing species.
Distinct neural couplings to shared goal and action coordination in joint action: evidence based on fNIRS hyperscanning

Abstract Joint action is central to human nature, enabling individuals to coordinate in time and space to achieve a joint outcome. Such interaction typically involves two key elements: shared goal and action coordination. Yet, the substrates entrained to these two components in joint action remained unclear. In the current study, dyads performed two tasks involving both sharing goal and action coordination, i.e. complementary joint action and imitative joint action, a task only involving shared goal and a task only involving action coordination, while their brain activities were recorded by the functional near-infrared spectroscopy hyperscanning technique. The results showed that both complementary and imitative joint action (i.e. involving shared goal and action coordination) elicited better behavioral performance than the task only involving shared goal/action coordination. We observed that the interbrain synchronization (IBS) at the right inferior frontal cortex (IFC) entrained more to shared goal, while left-IFC IBS entrained more to action coordination. We also observed that the right-IFC IBS was greater during completing a complementary action than an imitative action. Our results suggest that IFC plays an important role in joint action, with distinct lateralization for the sub-components of joint action.
Enhanced multi-antenna capabilities through small cell collaboration

Downlink Multi-User MIMO (MU-MIMO) is a spatial multiplexing technique in which multiple transmit antennas at an evolved Node Base station (eNB) are used to simultaneously serve multiple User Equipments (UEs), each on a different spatial layer, in such a way that the interference between the beams directed at co-scheduled UEs is kept as low as possible. Due to MU-MIMO's ability to provide large spatial multiplexing gains without requiring additional antennas on the UE, and its ability to overcome rank deficiency problems (which often limit single point-to-point spatial multiplexing), MU-MIMO capabilities have been highly emphasised in recent standardisation.
The psychological benefits of neuropsychological assessment feedback as a psycho-educational therapeutic intervention: A randomized-controlled trial with cross-over in multiple sclerosis

ABSTRACT Evidence supporting the direct therapeutic benefits of neuropsychological assessment (NPA) feedback relies mostly upon post-feedback consumer surveys. This randomized-controlled trial with cross-over investigated the benefits of NPA feedback in multiple sclerosis (MS). Seventy-one participants were randomly allocated to NPA with feedback or a “delayed-treatment” control group. The primary hypotheses were that NPA feedback would lead to improved knowledge of cognitive functioning and improved coping. Outcome instruments were administered by a research assistant blinded to group allocation. At 1-week post-NPA feedback there were no significant group-by-time interaction effects, indicating no improvement. But nor was there any significant deterioration in psychological wellbeing, despite most participants receiving “bad news” confirming cognitive impairment. At 1-month follow-up, within-subjects’ analyses not only found no evidence of any delayed deterioration, but showed clinically significant improvement (small-medium effects) in perceived everyday cognitive functioning, MS self-efficacy, stress and depression. Despite lack of improvement in the RCT component at 1-week post-NPA feedback, the absence of deterioration at this time, in addition to significant improvements in perceived cognitive functioning, self-efficacy and mood at follow-up, together with high satisfaction ratings, all support NPA feedback as a safe psycho-educational intervention that is followed by improved psychological wellbeing over time. Trial registration: Uniform Trial Number identifier: U1111-1127-1585. Trial registration: Australian New Zealand Clinical Trials Registry identifier: ACTRN12612000161820.
Applications of capillary electrophoresis in the fields of environmental, pharmaceutical, clinical and food analysis (2019-2021).

So far, the potential of capillary electrophoresis (CE) in the application fields has been increasingly excavated due to the advantages of simple operation, short analysis time, high-resolution, less sample consumption and low cost. This review examines the implementations and advancements of CE in different application fields (environmental, pharmaceutical, clinical and food analysis) covering the literature from 2019 to 2021. In addition, ultrasmall sample injection volume (nanoliter range) and short optical path lead to relatively low concentration sensitivity of the most frequently used UV-absorption spectrophotometric detection, so the pretreatment technology being developed has been gradually utilized to overcome this problem. Despite the review is focused on the development of CE in the fields of environmental, pharmaceutical, clinical and food analysis, the new sample pretreatment techniques of microextraction and enrichment which fit excellently to CE in recent three years are also described briefly. This article is protected by copyright. All rights reserved.
pRB-Depleted Pluripotent Stem Cell Retinal Organoids Recapitulate Cell State Transitions of Retinoblastoma Development and Suggest an Important Role for pRB in Retinal Cell Differentiation

Abstract Retinoblastoma (Rb) is a childhood cancer of the developing retina, accounting for up to 17% of all tumors in infancy. To gain insights into the transcriptional events of cell state transitions during Rb development, we established 2 disease models via retinal organoid differentiation of a pRB (retinoblastoma protein)-depleted human embryonic stem cell line (RB1-null hESCs) and a pRB patient-specific induced pluripotent (iPSC) line harboring a RB1 biallelic mutation (c.2082delC). Both models were characterized by pRB depletion and accumulation of retinal progenitor cells at the expense of amacrine, horizontal and retinal ganglion cells, which suggests an important role for pRB in differentiation of these cell lineages. Importantly, a significant increase in the fraction of proliferating cone precursors (RXRγ+Ki67+) was observed in both pRB-depleted organoid models, which were defined as Rb-like clusters by single-cell RNA-Seq analysis. The pRB-depleted retinal organoids displayed similar features to Rb tumors, including mitochondrial cristae aberrations and rosette-like structures, and were able to undergo cell growth in an anchorage-independent manner, indicative of cell transformation in vitro. In both models, the Rb cones expressed retinal ganglion and horizontal cell markers, a novel finding, which could help to better characterize these tumors with possible therapeutic implications. Application of Melphalan, Topotecan, and TW-37 led to a significant reduction in the fraction of Rb proliferating cone precursors, validating the suitability of these in vitro models for testing novel therapeutics for Rb.
Incidental learning in music reading: The music contingency learning task

The present report investigated whether nonmusicians can incidentally learn musical skills needed for sight-reading. On each trial, participants identified a note name written inside of a note on the musical staff. In Experiment 1, each note was presented frequently with the congruent note name (e.g., “do” with the note for “do”) and rarely with the incongruent names (e.g., “do” with the note for “fa”). With or without deliberate learning instructions, a robust contingency learning effect was observed: faster responses for congruent trials compared with incongruent trials. Participants also explicitly identified the meaning of the note positions more accurately than chance. Experiment 2 ruled out the potential influence of preexisting knowledge on the contingency learning effect by presenting notes most often with an incongruent note name. Robust learning was again observed, suggesting that participants acquired sufficient knowledge of musical notation to produce automatic influences on behaviour (e.g., akin to the interference effect previously found in skilled musicians). A congruency effect was additionally observed in Experiment 2, however. Experiment 3 further explored to what extent this congruency effect might be due to prior music knowledge and/or spatial stimulus–response compatibility between note and response locations (analogous to the SMARC effect). Overall, our results open up new avenues for investigating the incidental learning of complex material, musical or otherwise, and for reinforcing learning even further.
Association Between Intimate Partner Violence and Suicidal Ideation Among Female and Male Adults in South Korea: A Nationally Representative Longitudinal Study

This study sought to assess the prevalence of intimate partner violence (IPV) victimization and to examine the sex-stratified associations between IPV and suicidal ideation in South Korea. This study used nationally representative longitudinal survey data from 2011 to 2020 of the Korean Welfare Panel Study of 9732 married adults at baseline. Participants were annually asked about IPV experiences of verbal abuse, physical threat, or physical assault over the past year in 2011–2019. Suicidal ideation in the past year was assessed in the following year 2012–2020 of IPV experiences. Using multilevel logistic regression models, we examined the associations between IPV and suicidal ideation among married adults. The prevalence of verbal abuse, physical threat, and physical assault was respectively 19.8%, 3.0%, and 1.4% in females (n = 5056); and 18.8%, 2.7%, and 1.0% in males (n = 4676). After adjusting for potential confounders (e.g., lifetime suicidal ideation and random effects of individuals and households) in the same year when participants had IPV experiences, all types of IPV experiences were statistically associated with suicidal ideation in the following year among both females and males, except for physical threat among males. We found a statistically significant association between physical threat and suicidal ideation among females (adjusted odds ratio: 2.22, 95% confidence interval: 1.62, 3.04), whereas no association was observed among males. Our findings suggest that public health interventions related to suicidal behaviors that can be attributable to experiencing IPV are necessary among both females and males in South Korea.
CancerBERT: a cancer domain-specific language model for extracting breast cancer phenotypes from electronic health records

Abstract Objective Accurate extraction of breast cancer patients’ phenotypes is important for clinical decision support and clinical research. This study developed and evaluated cancer domain pretrained CancerBERT models for extracting breast cancer phenotypes from clinical texts. We also investigated the effect of customized cancer-related vocabulary on the performance of CancerBERT models. Materials and Methods A cancer-related corpus of breast cancer patients was extracted from the electronic health records of a local hospital. We annotated named entities in 200 pathology reports and 50 clinical notes for 8 cancer phenotypes for fine-tuning and evaluation. We kept pretraining the BlueBERT model on the cancer corpus with expanded vocabularies (using both term frequency-based and manually reviewed methods) to obtain CancerBERT models. The CancerBERT models were evaluated and compared with other baseline models on the cancer phenotype extraction task. Results All CancerBERT models outperformed all other models on the cancer phenotyping NER task. Both CancerBERT models with customized vocabularies outperformed the CancerBERT with the original BERT vocabulary. The CancerBERT model with manually reviewed customized vocabulary achieved the best performance with macro F1 scores equal to 0.876 (95% CI, 0.873–0.879) and 0.904 (95% CI, 0.902–0.906) for exact match and lenient match, respectively. Conclusions The CancerBERT models were developed to extract the cancer phenotypes in clinical notes and pathology reports. The results validated that using customized vocabulary may further improve the performances of domain specific BERT models in clinical NLP tasks. The CancerBERT models developed in the study would further help clinical decision support.
Recent Epidemiology and Risk Factors of Nonalcoholic Fatty Liver Disease

Because of the global obesity epidemic, the incidence and prevalence of nonalcoholic fatty liver disease (NAFLD) have increased worldwide, including among Koreans. Recently, the incidence rate of NAFLD in Korea was reported to be 45.1 per 1,000 person-years, and the prevalence as approximately 30% depending on the diagnostic methods used. The incidence of advanced fibrosis and hepatocellular carcinoma, as well as all-cause and liver-related mortality in NAFLD patients has increased substantially, imposing considerable public health costs in Korea. Genetic, demographic, environmental, and clinical factors are involved in the pathogenesis of NAFLD. Some genetic variants, such as patatin-like phospholipase domain-containing 3 (PNPLA-3) and sorting and assembly machinery component 50 (SAMM-50), play a major role in the occurrence of NAFLD. The risk of NAFLD and fibrosis increases with advancing age and in men. Nutritional factors, inadequate exercise, and sleep duration are also associated with increased risk of NAFLD. Obesity is a major risk factor for NAFLD; however, NAFLD in lean individuals has been noted in recent studies. Insulin resistance, type 2 diabetes, and metabolic syndrome and its components are closely associated with NAFLD development and liver fibrosis with various underlying mechanisms. Sarcopenia likely shares a common pathophysiology with NAFLD. The rapidly increasing incidence and prevalence of NAFLD and its complications, as well as the associated healthcare burden, warrant early assessment of NAFLD and its risk factors to prevent NAFLD-related complications in high risk groups.
Antenatal thyroid hormone therapy and antithyroid drug use in Norway from 2004 to 2018

Objective Thyroid disease during pregnancy is associated with adverse pregnancy outcomes and suboptimal fetal development. During the last decades, guidelines for diagnosing thyroid disease during pregnancy have changed considerably and there has been increased awareness. This study aimed to describe the prevalence of thyroid disease treatment over time among pregnant women in Norway. Design Nationwide register-based study. Methods We combined historical data from the Medical Birth Registry of Norway and the Norwegian Prescription Database, identifying pregnant women using thyroid therapy from 2004 to 2018. Results A total of 855,067 pregnancies were included in the analyses. The proportion of women using thyroid hormone replacement therapy during pregnancy increased from 1.46% (n = 800) in 2004 to 3.57% (n = 1940) in 2018. The proportion of women using antithyroid medications also increased from 0.04% (n = 20) in 2004 to 0.10% (n = 56). During these 15 years, the mean maternal age increased by 0.9 years. When adjusting for age, the risk for being on thyroid hormone replacement therapy during pregnancy increased by an average of 5% per year (odds ratio: 1.05, 95% CI: 1.05–1.05). Conclusion During the recent 15 years, there has been a substantial increase in the use of thyroid hormone therapy in Norwegian pregnant women. We speculate that this could be due to an increased awareness in combination with overdiagnosis because of inappropriate diagnostic criteria. To truly understand the possible causes and consequences of this development, further research is warranted.
Ruthenium Polypyridyl Complex Bound to a Unimolecular Chair-Form G-Quadruplex

The DNA G-quadruplex is known for forming a range of topologies and for the observed lability of the assembly, consistent with its transient formation in live cells. The stabilization of a particular topology by a small molecule is of great importance for therapeutic applications. Here, we show that the ruthenium complex Λ-[Ru(phen)2(qdppz)]2+ displays enantiospecific G-quadruplex binding. It crystallized in 1:1 stoichiometry with a modified human telomeric G-quadruplex sequence, GGGTTAGGGTTAGGGTTTGGG (htel21T18), in an antiparallel chair topology, the first structurally characterized example of ligand binding to this topology. The lambda complex is bound in an intercalation cavity created by a terminal G-quartet and the central narrow lateral loop formed by T10–T11–A12. The two remaining wide lateral loops are linked through a third K+ ion at the other end of the G-quartet stack, which also coordinates three thymine residues. In a comparative ligand-binding study, we showed, using a Klenow fragment assay, that this complex is the strongest observed inhibitor of replication, both using the native human telomeric sequence and the modified sequence used in this work.