Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of processing variables and in-vitro study of microparticulate system of nimesulide

Microparticulate systems of nimesulide (NIM) were prepared by modified solvent evaporation method using different variables such as polymer: drug (NIM) ratios (cellulose acetate, CA: nimesulide, NIM) (1:9, 1:6 and 1:3), agitation speeds (500-1500 rpm) and stirring time (15-30 min). The effects of processing variables were evaluated by microparticle size and entrapment efficiency. The average microparticle size increases from 66.8±1.45 to 87.3±1.06 µm with increase in the polymer concentration while reduces with increase in agitation speed and stirring time; but at the too higher speed gives irregular shape of particles. The highest entrapment efficiency (77.83±0.51%), size uniformity, free flowability, i.e., angle of repose (23.5±0.4o) and compressibility index (14.2±0.6%), of microparticles were found with 1:6 (polymer: drug ratio), at 1000 rpm and 20 min stirring time among all prepared microparticles (P < 0.05). The in-vitro drug release study of microparticles with optimized processing variables (agitation speed and time) were carried out and compared with conventional and marketed SR tablets. The conventional tablet releases maximum drug within 4 h while microparticulate system releases more than 14 h. All formulations followed first order release kinetic and diffusion controlled drug release (Higuchi model). These microparticles are stable at room temperature (25±1 °C) but agglomerate at elevated temperature (50±1 °C) by softening and fusion of the polymer observed under SEM study.
THE DESIGN OF VORTEX INDUCED VIBRATION FLUID KINETIC ENERGY HARVESTERS

Due to the rapid development in the field of microsystem technology during the last decade, micro energy sources become the bottleneck in most of the applications. In order to extend the usable range of environment energy sources, a fluid kinetic energy harvester is proposed. Compared to a hydro-turbine structure it is more robust and has a better performance at smaller scale. The related theoretical background is introduced as well as different simulations in order to optimize the performance are carried out. The demonstrator design based on those simulation results is tested and evaluated. First experimental results are presented and compared with simulation results.
Clause linking in Japhug

This paper presents a detailed description of clause linking in Japhug, based on a corpus of traditional narratives and conversations. It follows the methodology used in Dixon and Aikhenvald’s (2009) collective book on this topic, to ease crosslinguistic comparisons. Although Japhug has a very rich system of converbs, there is not a single meaning that requires a non-finite form: all subtypes of clause linking can be expressed exclusively with finite verb forms, and these indeed predominate in our corpus.
MONITORING OF THE ELECTRON BEAM SIZE AND POSITION IN THE AIR

A possibility of the operative control position of the electron beam with energy from 20 to 90 MeV at the exit of two-structure electron linac [1] has been investigated. The irradiated samples are situated in free air of the linac bunker. Special secondary emission monitors are developed for the operative control of the beam position on the illuminated target. The monitor signals are used by linac control system.
Using CFD as Preventative Maintenance Tool for the Cold Neutron Source Thermosiphon System

The cold neutron source (CNS) system of the Open Pool Australian Light-Water (OPAL) reactor is a 20 L cryogenically cooled liquid deuterium thermosiphon system. The CNS is cooled by forced convective helium which is held at room temperature during stand-by (SO) mode and at ~20 K during normal operation (NO) mode. When helium cooling stops, the reactor is shut down to prevent the moderator cell from overheating. This computational fluid dynamics (CFD) study aims to determine whether the combined effects of conduction and natural convection would provide sufficient cooling for the moderator cell under the influence of reactor decay heat after reactor shutdown. To achieve this, two commercial CFD software packages using an identical CFD mesh were first assessed against an experimental heat transfer test of the CNS. It was found that both numerical models were valid within the bounds of experimental uncertainty. After this, one CFD model was used to simulate the thermosiphon transient condition after the reactor is shut down. Two independent shutdown conditions of different decay-heat power profiles were simulated. It was found that the natural convection and conduction cooling in the thermosiphon were sufficient for dissipating both decay-heat profiles, with the moderator cell remaining below the safe temperature of 200°C.
CLINICAL RELEVANCE OF INTERFERON-GAMMA RELEASE ASSAY VERSUS TUBERCULIN SKIN TESTING FOR DIAGNOSIS OF LATENT TUBERCULOSIS IN CHRONIC HEMODIALYSIS PATIENTS.

Hydi Ahmed, Department of Clinical Pathology, Sohag University, Egypt E-mail: hydi.ahmed@yahoo.com There is no gold standard method for detecting latent tuberculosis infection (LTBI) in end stage renal disease (ESRD), the use of tuberculin skin test(TST) remains controversial due to its high rate of false results, new interferon gamma release assays have been developed for diagnosing LTBI as the QuantiFERON-TB Gold test(QFT-G). The aim of this work:was to evaluate the value of Quantiferon-TB Gold test and compare its performance with tuberculin skin test in the diagnosis of latent tuberculosis infection among ESRD patients receiving hemodialysis(HD). Patients and Methods:60 ESRD patients undergoing HD and 40 healthy controls were subjected to TST and QFT-G to diagnose Latent TB infection. Results:QFT-G and TST were positive in 31.7 % and 45 % of patients respectively. The overall agreement was 73.3% (statistically significant with moderate agreement, p=0.001 & k=0.44), while it was 70% in BCG vaccinated patients (statistically significant with fair agreement, p=0.003 & k=0.37) and 80% in non BCG vaccinated patients (statistically significant with moderate agreement, p=0.001 & k=0.56). There were no statistically significant differences between patients and controls as regards age, sex, duration of hemodialysis and history of contact to known TB patients. Conclusion:We conclude that QFT-G test shows overall moderate agreement with TST and it could be used in screening of LTBI in ESRD patients simultaneously with TST and QFT-G test is more specific and accurate than TST in BCG vaccinated patients as BCG vaccination reduces their agreement, increasing the risk of TST false positive results rather than QFT-G positivity but relatively high cost and need for laboratory instruments is a limitation of QFT-G test
Applications of Low Density Graph Codes in Two Source Coding Problems

In this thesis , we present the applications of low density graph codes in two different types of source coding problems. First, we consider asynchronous Slepian-'! \Tolf coding where the two encoders may not have completely accurate timing information to synchronize their individual block code boundaries, and propose LDPC design in this scenario . A new information-theoretic coding scheme based on source splitting is provided , which can achieve the entire asynchronous Slepian-Wolf rate region. Unlike existing methods based on source splitting, the proposed scheme does not require common randomness at the encoder and the decoder , or the construction of superletter from several individual symbols. We then design LDPC codes based on this new scheme, by applying the recently discovered source-channel code correspondence. Second , we consider the lossy source coding problem. In contrast with most prior work that has focused exclusively on the binary uniformly distributed source , we address the problem of lossy coding for sources with arbitrary alphabets and distributions. Built upon the idea of approximating the optimal output distribution indicated by the rate-distortion theory vvith a uniform distribution over a larger alphabet , we propose a multilevel coding scheme using LDGl\II codes t hat can approach the rate-distortion limit for a general source. Experimental results validate the effectiveness of both proposed methods.
SPECTROPHOTOMETRIC ASSAY OF TENELIGLIPTIN IN PHARMACEUTICAL TABLET DOSAGE FORM BY ION-PAIR COMPLEX METHOD USING BROMO PHENOL BLUE (BPB)

A simple Ultraviolet Spectrophotometric method has been developed for the determination of Teneligliptin in pharmaceutical formulations and in the tablet dosage form using Bromo Phenol Blue (BPB). The interaction of the drug with BPB results in the formation of an ionpair complex the composition of which is established as 1:1 (Drug: BPB) by Job’s continuous variation method. The wavelength of maximum absorbance of the Ion-pair complex is found to be 305 nm. The absorbance values of the Ion-pair complex are found to increase linearly with the increase in the amount of the drug Teneligliptin up to 300 μg/ml. This suggests the suitability of the method for the determination of the drug in the range 10 μg/ml to 300 μg/ml. This also shows the verification of the Beer-Lambert’s Law in this range. The method is successfully employed to evaluate the assay of commercial tablets in pharmaceutical formulations for Teneligliptin and the results agreed very well. The molar absorptivity and Sandell Sensitivity of the method are 1.877 x 10 4 lit. mol -1 . cm -1 and 0.02273 μg. ml -1 . cm 2 respectively.
Factors affecting user's online shopping behavior: Integrating the constraint-based and dedication-based relationship perspectives

The influence of dedication-based relationships on post-adoption behavior in recent information systems continuance literature has been explored in detail. However, such is not the case for constraint-based relationships. This study aims to examine the relationship between the antecedents and consequences of both dedication-based and constraint-based factors on information systems post-adoption using online shopping as an example. The results indicated that the antecedents of constraint-based influences - the effectiveness of online shopping websites (perceived operational competence and communication) and the perceptions of online shoppers’ closeness in the relationship (customer relationship investment and perceived cohesion) - have indirect positive effects on online shoppers’ continuance intention toward online shopping websites, as mediated by their trust in the online shopping website and their perceptions of the switching cost. The data also showed that constraint-based influences have a more significant effect than dedication-based influences (satisfaction and perceived usefulness) on the continuance intention toward online shopping websites. The paper verified the antecedents and effects of both constraint-based and dedication-based influences on online shoppers’ continued online shopping behavior. Moreover, this article validated the causal relationship between perceived cohesion and trust as well as relationship investment and perceived switching costs in the e-commerce setting. Key words: Information system continuance, post-adoption behaviors, dedication and constraint based influences, online shopping.
Analysis of the frequency-dependent response to wave forcing in the extratropics

Atmospheric CO2 concentrations, retrieved from spectral measurements made in the near infrared (NIR) by the SCIAMACHY instrument, using Full Spectral Initiation Weighting Function Modified Differential Optical Absorption Spectroscopy (FSI WFM-DOAS), are compared to ground based Fourier Transform Infrared (FTIR) data and to the output from a global chemistry-transport model. Analysis of the FSI WFM-DOAS retrievals with respect to the ground based FTIR instrument, located at Egbert, Canada, show good agreement with an average negative bias of approximately−4.0% with a standard deviation of ∼3.0%. This bias which exhibits an apparent seasonal trend, is of unknown origin, though slight differences between the averaging kernels of the instruments and the limited temporal coverage of the FTIR data may be the cause. The relative scatter of the retrieved vertical column densities is larger than the spread of the FTIR measurements. Normalizing the CO 2 columns using the surface pressure does not affect the magnitude of this bias although it slightly decreases the scatter of the FSI data. Comparisons of the FSI retrievals to the TM3 global chemistry-transport model, performed over four selected Northern Hemisphere scenes show reasonable agreement. The correlation, between the time series of the SCIAMACHY and model monthly scene averages, are ∼0.7 or greater, demonstrating the ability of SCIAMACHY to detect seasonal changes in the CO 2 distribution. The amplitude of the seasonal cycle, peak to peak, observed by SCIAMACHY however, is larger by a factor of 2–3 with respect to the model, which cannot be explained. The yearly means deCorrespondence to: P. S. Monks (psm7@le.ac.uk) tected by SCIAMACHY are within 2% of those of the model with the mean difference between the CO 2 distributions also approximately 2.0%. Additionally, analysis of the retrieved CO2 distributions reveals structure not evident in the model fields which correlates well with land classification type. From these comparisons, it is estimated that the overall bias of the CO2 columns retrieved by the FSI algorithm is <4.0% with the precision of monthly 1 ×1 gridded data close to 1.0%.
Provincial governors and their titulature in the sixth century

L 'auteur reexamine les intentions, le langage et la portee de la serie de Novelles edictees par Justinien dans les annees 535-536 en vue de reorganiser l'administration provinciale, L 'apparente contradiction presentee par l'evocation de glorieux passes locaux et l'exaltation simultanee de la grandeur romaine, par l'exhumation de litres romains traditionnels (praetor, consularis, etc.) au moment meme ou le grec remplace le latin comme langue de la juridiction, peut s'expliquer par un programme de restauration de l'autorite centrale sur la vie provinciale s'accompagnant d'une tentative d'alliance avec les assemblees provinciales pourfaire piece a la puissance insolente des aristocraties locales et asseoir l'autorite renforcee des gouverneurs : une cause perdue d'avance, cependant, comme on peut le constater des la fin du VIe siecle.
Drop-out bij de behandeling van kinderen met overgewicht

Probleemstelling. De behandeling van overgewicht bij kinderen kampt met problemen zoals vroegtijdig stoppen. Deze pilootstudie exploreert de redenen die gezinnen zelf aangeven om een behandeling te stoppen, gebaseerd op het ‘Barrieres tot Behandeling’ model van Kazdin en collega’s (1997) en onderliggende mechanismen voorgesteld door Garcia en Weisz (2002). Methode. Kind- en gezinskarakteristieken werden verzameld van 72 gezinnen die behandeling zochten voor een kind met overgewicht, 47 van hen vulden ook na afloop vragenlijsten in m.b. t. waargenomen barrieres. Resultaten. Barrierescores verschilden weinig tussen gezinnen die de behandeling afwerkten en gezinnen die uitvielen. Kinderen die vroegtijdig stopten, waren ouder, hadden meer overgewicht, en vertoonden meer gewichtsverlies. Deze gezinnen ervaarden de behandeling als minder noodzakelijk. Gezinnen met een lage SES raporteerden meer problemen van praktische aard die het volgen van een behandeling bemoeilijkten. Discussie. Hindernissen in de motivatie worden besproken. Verder betekent voor sommige jongeren het stopzetten van een behandeling niet noodzakelijk een falen van de therapie.
On the self-similar solutions of the crystalline mean curvature flow in three dimensions

We present two types of self-similar shrinking solutions of positive genus for the crystalline mean curvature flow in three dimensions analogous to the solutions known for the standard mean curvature flow. We use them to test a numerical implementation of a level set algorithm for the crystalline mean curvature flow in three dimensions based on the minimizing movements scheme of A. Chambolle, Interfaces Free Bound. 6 (2004). We implement a finite element method discretization that seems to improve the handling of edges in three dimensions compared to the standard finite difference method and illustrate its behavior on a few examples. 1. Crystalline mean curvature flow The understanding of the evolution of small crystals has been a challenging problem of material science and mathematical modeling. In this regime, the evolution seems to be governed by the surface energy, whose effects are usually modeled by mean curvature terms. Due to the lattice structure of a typical crystal, the surface energy density is anisotropic. In fact, it is postulated that the optimal shape (Wulff shape) is a convex polytope and such anisotropies are called crystalline. This causes difficulties for the definition of an anisotropic (crystalline) mean curvature and a suitable notion of solutions of the resulting surface evolution problem, and makes the development of an efficient numerical method challenging. The crystalline mean curvature was introduced independently by S. B. Angenent and M. E. Gurtin [5] and J. E. Taylor [57] to model the growth of small crystals, see also [11, 37]. The surfaces of solid and liquid bodies have a surface energy, which is usually expressed as the surface integral of a surface energy density σ : Sn−1 → (0,∞) over the boundary of a set E ⊂ R, representing the body,
Dealing with emergent design science research projects in IS

Multiple models, methods and frameworks have been proposed to guide Design Science Research (DSR) application to address relevant classes of problems in Information Systems (IS) discipline. While much of the ambiguity around the research paradigm has been removed, only the surface has been scratched on DSR efforts where researcher takes an active role in organizational and industrial engagement to solve a specific problem and generalize the solu-tion to a class of problems. Such DSR projects can have a significant impact on practice, link theories to real contexts and extend the scope of DSR. Considering these multiform settings, the implications to theorizing nor the crucial role of researcher in the interplay of DSR and IS projects have not been properly addressed. The emergent nature of such projects needs to be further investigated to reach such contributions for both theory and practice. This paper raises multiple theoretical, organizational and managerial considerations for a meta-level monitoring model for emergent DSR projects.
Spectrophotometric Determination of Furosemide in Pharmaceuticals Using Permanganate

Based on the reduction of permanganate by furosemide (FUR) in either acidic or basic medium, two simple, sensitive and cost-effective methods were proposed for the determination of FUR in bulk drug and in formulations. In method A, FUR was treated with a measured excess of permanganate in acid medium and the unreacted oxidant was measured at 550 nm, whereas in method B the reaction was carried out in alkaline medium and the resulting manganate was measured at 610 nm. In method A, the amount of permanganate reacted corresponds to the FUR content and the absorbance was found to decrease linearly with the concentration; while in method B, the absorbance increases with concentration. Under optimum conditions, working ranges was 3.0-24.0 µg ml -1 and 1.25-20.0 µg ml -1 by method A and method B, respectively. The calculated molar absorptivities are 9.06 × 10 3 and 1.36 × 10 4 L mol -1 cm -1 for method A and method B, respectively, with corresponding Sandell sensitivity values of 0.0365 and 0.0243 µg cm -2 . The limits of detection (LOD) and quantification (LOQ) have also been reported. Accuracy and precision for the assay were determined by calculating the intra-day and inter-day at three concentration levels; the intra-day RSD was < 2.7% and the accuracy was better than 2.8% (RE). The methods were successfully applied to the determination of FUR in tablets and injections dosage forms; either in monopreparations of FUR or in combination with amiloride HCl. The results tallied well with the label claim and were statistically compared with those of a reference method by applying the Student’s t-test and F-test. The accuracy was further ascertained from placebo and synthetic mixture analysis and also from spike-recovery method.
Seroprevalence of Toxoplasma Gondii in Immunocompetent and Immunocompromised Patients Using IgG - Modified Direct Agglutination Test (IgG MAT)

Background/Objective:The present study was conducted to assess the seroprevalence of Toxoplasma gondiiin and around Tirunelveli, Tamil Nadu, India by in-house IgG assay, using MAT. Methods:Serum samples from 175 immunodeficient and 175 immunocompetent patients were collected at Tirunelveli District, Tamil Nadu from May 2006 to October 2007. They were subjected to in-house IgG assay using Modified Direct Agglutination test (MAT). Results:Out of 350 patients tested by MAT, 39 patients (11.41%) had antibodies for toxoplasmosis with mean MAT titre of 53.85 ± 55.28 and the titre ranged from 1:20 to 1:160. Among the immunocompetent group of 175 patients, 18 patients (10.29%) had antibodies to toxoplasmosis whereas in immunodeficient group of 175 patients, 21 patients (12%) had antibodies for toxoplasmosis. The sensitivity, specificity of IgG MAT in detecting toxoplasmosis was 80 and 90 % respectively. Statistical analysis: The results were analysed by using the statistical software SPSS. Conclusions:The overall seroprevalence of toxoplasmosis in and around Tirunelveli District of Tamil Nadu was 11.41% based on IgG MAT. The study has proved that MAT is recommended as the most convenient method for serodiagnosis of toxoplasmosis and has the additional advantage of not requiring species-specific conjugates.
MAXIMIZING USER CONTENTMENT BY SAMBA

One of the communication techniques is that in which number of user is targeted by a sender. Cinematographic streaming services can be used for love or recorded events. In Cinematographic streaming over multicast network, user's bandwidth requirement is diverse because of bandwidth heterogeneity issue. For examples laptop, HD-TV, mobile devices all are working in different bandwidth. However, the available bandwidth needs to be assigned optimally when cinematographic streaming takes place over a multi cast network. Assignment of bandwidth based on user requirement, the users are grouped into different categories which help in handling bandwidth distribution simply. MDC (multiple description video) is used in media streaming to address this heterogeneity issue. In MDC, Cinematic source is encoded into multiple independent descriptions. A receiver is associated with one of the descriptions. A receiver joins different description to meet their bandwidth necessity. Streaming quality at receiver side is interrelated to the number of descriptions acknowledged. So it is important but big problem for MDC cinematic multicast is assigning bandwidth to each description in order to make best use of available bandwidth so that user contentment can be optimized. In this paper we present if the description number is greater than or equal to a certain threshold (e.g. minimum 100kb/s and maximum10Mb/s bandwidth requirement, such threshold is seven descriptions), there is an precise and simple solution to achieve maximum user contentment, (meeting all the bandwidth requirements) but for the situation when the description number is lesser, we present heuristic called simulated annealing for MDC bandwidth assignment (SAMBA) to allocate bandwidth to each description and we Simulate the assignment techniques