Miracle-dz/UniFAR-FTUs huggingface dataset:
Gene- and cell-based therapies for cardiovascular diseases: current status and future directions

Recent advances in understanding the molecular and cellular basis of cardiovascular diseases, together with the availability of tools for genetic manipulation of the cardiovascular system, offer possibilities for new treatments. Gene therapies have demonstrated potential usefulness in treating complex diseases such as hypertension, atherosclerosis and myocardial ischaemia based on studies of various animal models. Some of these experimental therapies have transitioned into clinical trials to assess their safety, feasibility and therapeutic potential in humans with cardiovascular disease. The recent isolation of adult progenitor cells with the capacity to differentiate into endothelial and cardiomyocyte phenotypes has opened an exciting era of cell therapies for vascularization and repair of ischaemic tissues and injured blood vessels. Despite these significant developments, we believe that the successful translation of these experimental therapies into clinical practice will require safer and more effective vectors and delivery tools, a deeper knowledge of progenitor cell biology and, finally, the documentation of efficacy and safety through multicentre randomized trials. c 2004 Published by Elsevier Ltd on behalf of The European Society of Cardiology.
DCount - A Probabilistic Algorithm for Accurately Disaggregating Building Occupant Counts into Room Counts

—Sensing accurately the number of occupants in the rooms of a building enables many important applications for smart building operation and energy management. A range of sensor technologies has been studied and applied to the problem. However, it is costly to achieve high accuracy by instrumenting all rooms in a building with dedicated occupant sensors. In this paper, we propose a new concept for estimating accurate room-level counts of occupants. The idea is to disaggregate accurate building-level counts via existing common sensors available at the room level. This solution is cost-effective as it scales to large buildings without requiring dedicated sensors in each room. We propose an algorithm named DCount that implements this concept. Our results document that DCount can provide room-level counts with a low normalized root mean squared error of 0.93. This is a major improvement compared to a state-of-the-art algorithm using common sensors and ventilation rate measurements resulting in a normalized root mean squared error of 1.54 on the same data set. Further more, we demonstrate how the results enable occupant-driven analysis of plug-load consumption which is one out of many applications using accurate room-level counts of occupants we hope to enable by proposing DCount.
cc sd-0 00 14 96 9 , v er si on 1-1 D ec 2 00 5 Palindromic continued fractions

It is widely believed that the continued fraction expansion of every irrational algebraic number α is either eventually periodic (and this is the case if, and only if, α is a quadratic irrationality) or contains arbitrarily large partial quotients, but we seem to be very far away from a proof (or a disproof). A preliminary step consists in providing explicit examples of transcendental continued fractions. The first result of this type is due to Liouville [11], who constructed real numbers whose sequence of partial quotients grows very fast, too fast for being algebraic. Subsequently, various authors used deeper transcendence criteria from Diophantine approximation to construct other classes of transcendental continued fractions. Of particular interest is the work of Maillet [12] (see also Section 34 of Perron [13]), who was the first to give examples of transcendental continued fractions with bounded partial quotients. Further examples have been provided by Baker [4, 5], Davison [6], Queffélec [14], Allouche et al. [3] and Adamczewski and Bugeaud [1], among others.
Expressed in Transgenic Tobacco in Field Tests following Attack by Insects1

The expression of chloramphenical acetyl transferase (CAT) protein driven by the wound-inducible promoter from the proteinase inhibitor 11 K (pin2) gene was examined in whole tobacco (Nicotiana tabacum L.) plants under field conditions. Mechanical wounding of the field-grown leaves caused an accumulation of CAT protein in these leaves which begins several hours after wounding and continues to accumulate for about 36 hours. When sections of leaves were assayed for accumulation of CAT protein following wounding, the CAT protein was found to accumulate in the apical portions of the leaves. When endogenous insects attacked the leaves of transgenic plants grown in the field, the plants responded by inducing CAT protein. The mesophyll cells of the leaf were the site of expression of the CAT protein rather than the mid-vein or major veins within the leaf blade, indicating that the wound-inducible pin2 promoter specifically directs the synthesis of novel genes in tissues preferentially consumed by larval insects. are then free to act on their substrates, the plants' cell walls, to release small mol wt oligosaccharides (1, 2, 16). These oligosaccharides have been termed PIIF2. They are believed to be the signal which interacts with unwounded cells in an as yet undetermined manner to induce the de novo synthesis of proteinase inhibitor mRNA and protein (9). These genes have been used in whole plants to express the native inhibitors (17) or foreign proteins (18) under wound-inducible control allowing examination of the mechanisms of pin2 gene activation. The present study was undertaken to better define how plants express biochemical defensive proteins in response to insect attack. MATERIALS AND METHODS
Experimental Characterization of a Chip-Level 3-D Printed Microjet Liquid Impingement Cooler for High-Performance Systems

The chip-level bare die direct liquid impingement jet cooling is regarded as a highly efficient cooling solution for high-performance applications. Furthermore, it shows potential to be integrated inside the chip package. In previous studies, we demonstrated this cooling concept using a prototype fabricated with mechanical micromachining using polymers. With the improvement of fabrication resolution, additive manufacturing or 3-D printing technology enables the fabrication of low-cost polymer microjet coolers with complex internal 3-D geometries and allows easy customization of the cooler design. In this paper, a chip-level impingement jet cooler with a <inline-formula> <tex-math notation="LaTeX">$4 \times 4$ </tex-math></inline-formula> jet array and 575-<inline-formula> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula> nozzle diameter is fabricated with high-resolution stereolithography, and assembled directly on the top of the bare die. The modeling study shows that the pressure drop in the 3-D printed cooler is reduced by 24% compared to the micromachined (MM) cooler with the same nozzle dimensions thanks to an improved more complex internal geometry. The fabrication quality and tolerances of the printed cooler are evaluated using optical measurements, scanning acoustic microscope (SAM) inspection, and cross-sectional analysis, showing a measured average nozzle diameter of 575 <inline-formula> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula> compared to the designed nozzle diameter of 600 <inline-formula> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula>. Moreover, the 3-D computational fluid dynamics (CFD) simulations used in this paper are experimentally validated by chip temperature measurements. The achieved minimal thermal resistance of 3-D printed <inline-formula> <tex-math notation="LaTeX">$4 \times 4$ </tex-math></inline-formula> cooler is 0.16 cm<inline-formula> <tex-math notation="LaTeX">$^{2}\cdot \text{K}$ </tex-math></inline-formula>/W for a flow rate of 1000 mL/min. The benchmarking study shows the cooler size can be reduced by a factor of 6.5 by using the 3-D printing technology compared to the MM cooler.
Modified Election algorithm in Distributed System using election commission & comparision with original bully algorithm & ring algorithm

: In this paper an election algorithm is presented that can be used in distributed systems to elect a coordinator. Many distributed algorithms need one process to act as a leader or coordinator to make synchronization between different processes. There are various algorithms that elect a particular node as coordinator from all the different nodes in the distributed network. This paper will present a modified version of bully election algorithm using a new concept called election commission. This approach will not only reduce the number of messages per election but also minimize total number of elections and hence it will minimize network traffic, redundant elections.
SURFACE ANTIGENS OF HUMAN MALIGNANT MELANOMA Recognition of Autoantibodies with Unusual Characteristics*

Our serological analysis of mal ignant melanoma has focused on cell surface antigens detected by reactions with autologous serum (1, 2). Cultured lines of melanoma cells and companion skin fibroblasts from the same individual serve as standard target cells in mixed hemadsorption (MHA) and immune adherence (IA) assays. Absorption tests with cells from autologous, allogeneic, and xenogeneic sources determine the specificity of reactions observed between melanoma cells and autologous serum. In this way, three distinctive melanoma surface antigens, designated AU, BD, and AH, have been defined (1, 2). AU and BD belong to a class of individually distinct surface antigens which show an absolute restriction to autologous melanoma cells (1, 2). The other, AH, represents a class of shared melanoma ant igens which has been detected on 5 out of 12 melanomas, but not on corresponding autologous fibroblasts or on other normal or mahgnan t ttssues (2)
Epithelial Cells Cellular Inflammatory Responses in Lung Leucine Zipper Expression and Modulates Ethanol Upregulates Glucocorticoid-Induced

Alcohol abuse is associated with immunosuppressive and infectious sequelae. Particularly, alcoholics are more susceptible to pulmonary infections. In this report, gene transcriptional proﬁles of primary human airway epithelial cells exposed to varying doses of alcohol (0, 50, and 100 mM) were obtained. Comparison of gene transcription levels in 0 mM alcohol treatments with those in 50 mM alcohol treatments resulted in 2 genes being upregulated and 16 genes downregulated by at least 2-fold. Moreover, 0 mM and 100 mM alcohol exposure led to the upregulation of 14 genes and downregulation of 157 genes. Among the upregulated genes, glucocorticoid-induced leucine zipper (GILZ) responded to alcohol in a dose-dependent manner. Moreover, GILZ protein levels also correlated with this transcriptional pattern. Lentiviral expression of GILZ small interfering RNA in human airway epithelial cells diminished the alcohol-induced upregulation, conﬁrming that GILZ is indeed an alcohol-responsive gene. Gene silencing of GILZ in A549 cells resulted in secretion of signiﬁcantly higher amounts of inﬂammatory cytokines in response to IL-1 b stimulation. The GILZ-silenced cells were more resistant to alcohol-mediated suppression of cytokine secretion. Further data demonstrated that the glucocorticoid receptor is involved in the regulation of GILZ by alcohol. Because GILZ is a key glucocorticoid-responsive factor mediating the anti-inﬂammatory and immunosuppressive actions of steroids, we propose that similar signaling pathways may play a role in the anti-inﬂammatory and immunosuppressive
SystemProtective Immunity in the Central Nervous and IL-10 Elicits Regulatory T Cell-Mediated Encoding an Encephalitogenic Determinant Coadministration of Plasmid DNA Constructs

We have previously shown that Ag-speciﬁc IL-10-producing regulatory T cells (Tr1) participate in the regulation of experimental autoimmune encephalomyelitis and that their speciﬁcity undergoes determinant spread in a reciprocal manner to effector T cell speciﬁcity. The current study shows that coadministration of plasmid DNA vaccines encoding IL-10 together with a plasmid encoding a myelin basic protein (MBP) encephalitogenic determinant during an ongoing disease rapidly ampliﬁes this Tr1-mediated response, in a disease-speciﬁc manner. Thus, coadministration of both plasmids, but not the plasmid DNA encoding MBP alone, rapidly suppresses an ongoing disease. Tolerance included elevation in Ag-speciﬁc T cells producing IL-10 and an increase in apoptosis of cells around high endothelial venules in the CNS after successful therapy. Tolerance could be transferred by MBP-speciﬁc primary T cells isolated from protected donors and reversed by neutralizing Abs to IL-10 but not to IL-4. Due to the nature of determinant spread in this model, we could bring about evidence implying that rapid and effective induction of Tr1-induced active tolerance is dependent on redirecting the Tr1 response to the epitope to which the effector function dominates the response at a given time. The consequences of these ﬁndings to multiple sclerosis, and possibly other inﬂammatory autoimmune diseases are discussed. The Journal of Immunology, 2006, 177: 8241–8247.
BOTH 5-AMINOLEVULINIC ACID AND BILIVERDIN OVERCOME INHIBITION BY GABACULINE IN ETIOLATED A VENA SATIVA L. SEEDLINGS

Etiolated APena sativa L. seedlings grown in the presence ofpbaculine (5-amino-1,3-cyclohexadienylcarboxylic acid) contained reduced levels of phytochrome as shown by spectrophotometric and immunochemical assays. Photochromic phytochrome levels in gabaculine-grown plants were estimated to be 20% of control plants, while immunoblot analysis showed that the phytochrome protein moiety was present at approximately 50% of control levels. Gabaculine-grown seedlings administered either 5-aminolevulinic acid or biliverdin exhibited a rapid increase of spectrophotometrically detectable phytochrome. Phytochrome concentrations estimated immunochemically did not similarly increase throughout treatment with either compound. Similar experiments with 5-antino(4-14C levulinic acid showed radiolabeling of phytochrome with kinetics that paralleled the spectally detected increase. These results are consistent with (a) the intermediacy of both 5-aminolevulinic acid and biliverdin in the biosynthetic pathway of the phytochrome chromophore and (b) the lack of coordinate regulation of chromophore and apoprotein synthesis in Avena seedlings.
Money Overhang, Credit Overhang and Financial Imbalances in the Euro Area

This paper focusses on the relation between external imbalances and domestic money and credit growth in the euro area. We compute money and credit overhang both for the euro area as a whole and for individual member countries. Our results show that both aggregate money and credit overhang have trend-like increased since the early 2000s. The increase in money overhang has been rather evenly spread over the member states but the increase in credit overhang has been unevenly spread and has mainly occurred in the GIIP countries. We apply panel analysis to detect temporal patterns between the developments in money overhang, credit overhang and external indebtedness. Looking at the groups of GIPS countries in isolation, net debt flows do play a significant role to explain money and credit overhang.
Enhancing Productivity of Concentrating Solar Distilating System Accompanied with PCM at Hot Climates

Solar energy is abundant in rural areas in Iraq. As such, solar distillation is the best solution for Iraqi rural areas that suffer from a lack of distilled water. Solar distillation has many advantages and it uses freely available solar energy. It is a simple technology and more economical than other available methods. In this study, a novel design was fabricated and installed in Baghdad city to solve a problem facing many hot climates using distillation, where the simple still productivity was paused for the period 12 AM to 3 PM. The results show that this proposed system increased productivity by 120.8% without any cooling aids. The still productivity was increased by 337.36% with the still cover cooling by forced convection (moving air with the help of a fan) after 4 PM. Moreover, using water to cool the lid after 4 PM increased productivity by 403% compared with simple solar still alone. The solar air temperature has the dominant effect on this problem. The reduction in energy lost to air, particularly during the time interval from 12 AM to 3 PM, pauses the distillation process. This results in reducing the evaporation energy that depends mainly on it. The cost of the proposed system was acceptable and within the means of people in remote areas.
Three-Dimensional Optimal Sliding-Mode Guidance for Homing Missiles Against Maneuvering Target

Abstract—A new missile guidance law is proposed for highly maneuvering target by integrating optimal and sliding-mode control theories based on state dependent Riccati equation (SDRE) to achieve robustness against external disturbances, i.e. target accelerations. The guidance acceleration command has been derived based on three-dimensional engagement kinematics. The new guidance method’s robustness against disturbances is proved by the second method of Lyapunov. The proposed guidance law requires the maximum value of target acceleration, and therefore on the contrary to traditional augmented proportional navigation guidance (APNG) law, exact information about target acceleration is not necessary, and hence it is simple to implement in practical applications. Considering several scenarios and different types of target accelerations simulations are carried out. Simulation results show that the proposed guidance law has better robustness, faster convergence, and smaller final time and control effort in comparison to the sliding-mode guidance (SMG) and APNG laws.
RISK FACTORS ASSOCIATED WITH HOOKWORM INFECTION AMONG PATIENTS ATTENDING USMANU DANFODIYO UNIVERSITY CLINIC, MAIN CAMPUS, SOKOTO, SOKOTO STATE, NIGERIA

To determine the risk factors associated with Hookworm infection among patients attending Usmanu Danfodiyo University Clinic, main Campus, a cross sectional study was conducted. A total of 100 stool samples were collected and analyzed using wet mount and Formol ether concentration techniques. An overall prevalence of 71.0% was obtained. Prevalence was higher among males (73.2%), age group 3-17 years (89.5%), farmers (90.0%) and patients who do not wash hands after meals (87.2%). Chi square and Binary logistic regression statistical analyses indicated no significant association of hookworm infection and gender, age, occupation and hand washing after meals (P>0.05). However, it was found that open defecation (χ=2.563, P= 0.045), ignorance of hookworm infection (χ=0.127, P= 0.043), having dirty finger nails (χ=17.04, P= 0.034), walking barefooted (χ=12.366, P= 0.045), not washing hands after toilet (χ=59.507, P= 0.000) and fetching water from wells and rivers (χ= 25.127, P= 0.029) were the most important risk factors associated with hookworm infection in the study area. Mass drug administration, health education, personal hygiene, and provision of portable drinking water and public toilets are highly recommended among the study population.
A decrease of the gas exchanges between galaxies and the IGM , from 12 to 6 billion years ago

Using a representative sample of 65 intermediate mass galax ies tz∼ 0.6, we have investigated the interplay between the main ingredients of chemi cal evolution: metal abundance, gas mass, stellar mass and SFR. All quantities have been esti mated using deep spectroscopy and photometry from UV to IR and assuming an inversion of the S chmitt-Kennicutt law for the gas fraction. Six billion years ago, galaxies had a mean g as fraction of 32%± 3, i.e. twice that of their local counterparts. Using higher redshift sam ples from the literature, we explore the gas-phases and estimate the evolution of the mean gas fra ction of distant galaxies over the last 11 Gy. The gas fraction increases linearly at the rat of 4% per Gyr fromz ∼ 0 to z∼ 2.2. We also demonstrate for a statistically representative s ample that< 4% of thez∼ 0.6 galaxies are undergoing outflow events, in sharp contrast wi th z∼ 2.2 galaxies. The observed co-evolution of metals and gas over the past 6 Gyr favours a sc enario in which the population of intermediate mass galaxies evolved as closed-systems, c onverting their own gas reservoirs into stars.
KNN and SVM Classification for Chainsaw Identification in the Forest Areas

We present in this paper a comparative study of two classifiers, namely, SVM (support vector machine) and KNN (K-Nearest Neighbors), which we combine to MFCC (MelFrequency Cepstral Coefficients) in order to make possible the detection of chainsaw’s sounds in a forest environment. Optimization’s calculation of the relevant characteristics of the sounds recorded in the forest and the judicious choice of the key parameters of the classifiers allows us to obtain a true positive rate of 95.63% for the SVM-LOG-KERNEL and 94.02% for the KNN. The SVM-LOG-KERNEL classifier offers a better classification result and a processing time 30 times faster than KNN. Keywords—KNN Algorithm; SVM Algorithm; MFCC; sound recognition; forest monitoring; machine learning
High-Quality Genome Sequence Assembly of R.A73 Enterococcus faecium Isolated from Freshwater sh mucus Exhibiting high Probiotic Potential

Rim El Jeni Institut National des Sciences et Technologies de la Mer, Salammbo Tunis / Institut Pasteur de Tunis Kais Ghedira Institut Pasteur de Tunis Monia El Bour Institut National des Sciences et Technologies de la Mer, Salammbo Tunis Sonia Abdelhak Institut Pasteur de Tunis Alia Ben Kahla Institut Pasteur de Tunis Balkiss Bouhaouala-Zahar (  balkiss.bouhaouala@fmt.utm.tn ) Institut Pasteur de Tunis https://orcid.org/0000-0003-3147-245X
DMD056663 1191..1201

HC-04 cells were evaluated as an in vitro model for mechanistic study of changes in the function of hepatic CYP3A during virus infection. Similar to in vivo observations, infection with a first generation recombinant adenovirus significantly inhibited CYP3A4 catalytic activity in an isoform-specific manner. Virus (MOI 100) significantly reduced expression of the retinoid X receptor (RXR) by 30% 96 hours after infection. Cytoplasmic concentrations of the pregnane X receptor (PXR) were reduced by 50%, whereas the amount of the constitutive androstane receptor (CAR) in the nuclear fraction doubled with respect to uninfected controls. Hepatocyte nuclear factor 4a (HNF-4a) and peroxisome proliferator-activated receptor g coactivator 1a (PGC-1a) were also reduced by ∼70% during infection. Virus suppressed CYP3A4 activity in the presence of the PXR agonist rifampicin and did not affect CYP3A4 activity in the presence of the CAR agonist CITCO [6-(4-chlorophenyl) imidazo [2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime], suggesting that virus-induced modification of PXR may be responsible for observed changes in hepatic CYP3A4. The HC-04 cell line is easy to maintain, and CYP3A4 in these cells was responsive to known inducers and suppressors. Dexamethasone (200 mM) and phenobarbital (500 mM) increased activity by 230 and 124%, whereas ketoconazole (10 mM) and lipopolysaccharide (LPS) (10 mg/ml) reduced activity by 90 and 92%, respectively. This suggests that HC-04 cells can be a valuable tool for mechanistic study of drug metabolism during infection and for routine toxicological screening of novel compounds prior to use in the clinic.