Miracle-dz/UniFAR-FTUs huggingface dataset:
Transcriptional regulation of sphingolipid metabolism in budding yeast

Global control for the synthesis of lipids constituting a bilayer of cell membranes is known to be with a small number of transcription factors called master transcriptional regulators, which target a wide range of genes encoding lipid metabolism enzymes and/or their regulators. Although master transcriptional regulators of glycerophospholipids and sterols have been identified in both yeast and mammals, this aspect of sphingolipid metabolism is not yet understood. In the present study, we identified the C2H2-type zinc finger transcription factor, Com2, as a master transcriptional regulator of sphingolipid metabolism in the budding yeast, Saccharomyces cerevisiae. The target of rapamycin complex 2 (TORC2)-activated protein kinase Ypk1 is known to regulate sphingolipid metabolism. Activated Ypk1 stimulates the activity of serine palmitoyl transferase (SPT), the first-step enzyme in sphingolipid biosynthesis, by phosphorylating and inhibiting Orm1/2, a negative regulator of SPT. This regulation of SPT activity is thought to be a major pathway in the regulation of sphingolipid metabolism. In the present study, we found that inhibition of sphingolipid synthesis upregulates the expression of Com2, which in turn leads to the concomitant expression of Ypk1. The upregulation of Ypk1 expression was found to be dependent on a putative Com2-binding site in the YPK1 promoter. Our results also suggested that Com2 senses intracellular sphingolipid levels through a pathway independent of TORC2-Ypk1-mediated sensing of sphingolipids. Our results revealed an additional layer of mechanistic regulation that allows cells to maintain appropriate levels of sphingolipid biosynthesis and to rapidly induce this process in response to environmental stresses. Significance Statement One of the major regulatory mechanisms involved in the control of lipid metabolism in bilayers of biological membranes is regulation at the transcriptional level by master transcriptional regulators that control the transcription of genes encoding lipid metabolism enzymes and/or their regulators. In the present study, we identified the C2H2-type zinc finger transcription factor Com2 as a master transcriptional regulator in sphingolipid metabolism. We found that Com2 regulates sphingolipid metabolism by transcriptionally controlling the expression of Ypk1, which regulates Orm1/2, a negative regulator of serine palmitoyl transferase, the first-step enzyme in sphingolipid biosynthesis, through phosphorylation. Our study revealed a new layer of regulation that allows the maintenance of an appropriate level of sphingolipid biosynthesis for a rapid response to environmental stresses.
Translation, Cultural Adaptation and Validation of Behavioral-Emotional Reactivity Index for Adolescents

1 Saima Saeed* 2 Farah Malik 3 Suzanne Bartle Haring 1. PhD Scholar, Institute of Applied Psychology, University of The Punjab, Lahore, Punjab, Pakistan 2. Professor, Institute of Applied Psychology University of The Punjab, Lahore, Punjab, Pakistan 3. Professor. Program Director, Couple and Family Therapy, College of Education and Human Sciences, Hdfs, The Ohio State University, Columbus, United States PAPER INFO ABSTRACT Received: July 29, 2021 Accepted: October 15, 2021 Online: October 20, 2021 Measuring differentiation of self in terms of behavioral/emotional reactivity towards parents is important because of the complex parent-child connection. This needs a valid and reliable measure to assess the differentiation of self particularly in a relationship with parents. Behavior\Emotional Reactivity Index is such a tool that fulfills this purpose. The present study was carried out to culturaly adapt and translate BERI into the Urdu language and establish the psychometric properties of Urdu version. A sample of 303 adolescents of age (M = 16.07, SD = 1.77) was taken from different schools and colleges. Scale was split into Mother and father forms for the convenience of respondents. Findings supported the original factor structure of the BERI-original version. Higher-order factor analysis showed good fit indices with excellent alpha ranges (α= .91 to α=.80). BERI scores were compared for the adolescents who were securely attached with parents and insecurely attached with parents which showed a significant difference between the groups. BERI-Urdu version was found to be a valid and reliable measure in the Pakistani cultural context which gives researchers new directions to work with adolescents.
Laser Spatial Profile Measurement Device

A device is described which measures the spatial profile of a laser in either the near field or far field. The laser pattern is imaged onto a pyroelectric vidicon (PEV) camera. A single frame is extracted from the camera and the image is processed using a PDP 11/20 to correct for PEV imperfections. The device will measure lasers having wavelengths of 2 µm to 10.6 µm. Detailed characteristics of the device are given.
Freely Engaged: Volition and Work Engagement Among Temporary Agency Workers of the Indian IT Industry

A lack of job security and other challenges mark the circumstances of temporary agency workers (TAWs). Yet, data from 511 TAWs of the Indian information technology (IT) industry captured via a structured questionnaire revealed the presence of volition or TAWs holding temporary jobs by choice. The study was conducted in two phases. In phase one, logistic regression was used to differentiate between voluntary and involuntary TAWs. In phase two, multiple regression was used to analyse the influence of volition on work engagement–overall and its individual components (vigour, dedication, and absorption). Logistic regression analysis showed that TAWs who were younger, single, educated in smaller cities and had worked for less than a year with a client were more likely to voluntarily choose temporary work. Further, multiple regression analysis demonstrated that such volition significantly boosts TAWs’ work engagement, in line with Self-Determination Theory’s perspective on autonomous motivation. The predictive model of categorizing TAWs into voluntary and involuntary groups based on demographic and job characteristics will help client and staffing organizations design customized policies for each group and promote factors enabling voluntary selection of temporary work arrangements.
Productivity changes in Taiwan's port industry incorporating environmental regulations on harbor water quality

Abstract This paper evaluates the productivity changes in Taiwan's port industry for the period 2003–2007. Based on a ‘three-year-window’ data envelopment analysis method, Luenberger productivity indicators are employed to estimate the productivity changes that account for the success of attempts by port agents to control harbor water quality. This is one of the typical environmental concerns in port operations that prior studies on port productivity changes over time have not considered. The results show that the productivity of Taiwan's port industry has experienced growth over the study period, regardless of whether water quality has been considered or not. At a disaggregated level, however, if a port agent has succeeded in controlling water quality, but we do not consider it, the results will misclassify the agent by understating the port's productivity.
Optimization of Millet Axial Flow Threshing and Separation Device Based on Discrete Element Method

: The difficulties of threshing and separation of millet have not been solved yet which has restricted the development of the millet industry because of the special biological structure and lack of professional agricultural machinery. In order to improve the quality of millet harvest and meet the market demand for millet, in this paper, according to the branching structure of millet, the millet earhead model was established by Discrete Element Method. Using virtual models of millet and device, the simulation tests were carried out whose results have shown that the threshing effect of the rasp-bar threshing element is better than that of the teeth threshing element. Then the rotor structure was optimized into a combined type of the rasp-bar and the teeth. A three-factor five-level quadratic orthogonal rotation combination test was carried out whose results have shown that the combined rotor can meet the requirements of millet harvest.
Vibration energy harvesting system for railroad safety based on running vehicles

This research is focused on energy harvesting from track vibration in order to provide power for the wireless sensors which monitor railroad health. Considering that track vibration has vibration energy, a new method is proposed in the paper to harvest energy based on the piezoelectric effect. The piezoelectric generator called drum transducer is the key part for track vibration energy harvesting. The model of drum transducer is established and the simulation results show that it can generate 100 mW in real track situation. In addition, an experiment rig is developed and its vibration model is also established. The simulation and experiment results show that peak open-circuit voltage of piezoelectric generator is about 50–70 V at the full load of the train. The whole track vibration energy harvesting system is analytically modeled, numerically simulated, and experimentally realized to demonstrate the feasibility and the reliability of the theoretical model. This paper is the theoretical basis of harvesting, recovering and recycling of the track vibration energy for track safety.
Signal Processing Methods for Gearbox Fault Detection.

Abstract : Methods of accounting for load variation in vibration signals from helicopter transmission systems are presented. These methods are based on autoregressive moving-average (ARMA) models, and several ARMA parameter estimation schemes are presented. Simulations of load variation are carried out, and a prediction error filter, based on the ARMA models, is used to generate a residual signal. Fault indices extracted from the residential signal are used to indicate the presence or absence of a fault. The results of the simulations suggest that this method of fault detection is able to detect both general and local fault conditions.
DTC and TDC IC Design for Ultra-Low-Power ADPLL

The technology scaling favors the Digital PLLs, which is reconfigurable. In the traditional fractional-N ADPLL, whether counter-based or divider based, DCO and TDC are the main two power consuming blocks. Modifying the phase detection part based on phase prediction makes the architecture more energy-efficient. The new architecture leads to the first wireless ADPLL breaking 1mW barrier. However, the in-band spurs are very high and DTC gain calibration does not work very well. This thesis proposes a pseudo phase domain model to determine the in-band spur level and validates the accuracy through simulations. It also improves the LMS DTC gain calibration algorithm to solve the problem when FCW fractional part is small DTC gain cannot calibrate correctly. Furthermore, pre-distortion is used to cancel DTC nonlinearity. Apart from theoretically analysis, a first-order $\Sigma-\Delta$ TDC is taped-out, to measure DTC's nonlinearity.
Comparison of Biophysical Characteristics and Predicted Thermophysiological Responses of Three Prototype Body Armor Systems Versus Baseline U.S. Army Body Armor Systems

Abstract : Modern day dismounted military are commonly required to perform high physical work at high intensities in a variety of environmental conditions while facing challenging training and combat engagements. To optimize warfighter physical performance while providing protection from kinetic threats, tradeoffs must be made between physical performance and the adverse effects of the weight and functional characteristics of equipment and clothing carried and worn by the individual Soldiers. The work outlined in this report provides: 1) a quantitative assessment of the biophysical characteristics of three prototype body armor configurations, 2) a comparison to current baseline U.S. Army body armor systems, and 3) mathematical predictions of maximal work times in three different environmental conditions. This work provides a cost effective and scientifically valid method of making comparisons of clothing and equipment changes prior to conducting human research.
LEANNESS LEVEL OF MANUFACTURING COMPANIES - A SURVEY ON LEAN MANUFACTURING IMPLEMENTATION

Lean manufacturing is a well-known methodology to optimize company processes towards the increase of company performance. Despite the fact its benefits were confirmed over many years, the rate of successful implementations is questionable. This article focuses on an evaluation of the leanness level given by a level of implementation of lean manufacturing methodology in manufacturing companies. It brings results gained from the survey made in the production companies related to the Czech Republic. The survey focused on an evaluation of the use of basic lean manufacturing tools. Based on acquired data, the leanness level of the companies was calculated. Results showed that an overall average leanness level is 56%. Big differences between large companies and small and medium companies were found. A gap between theoretical promoted tools and their utilization in real companies was found as well. There is a discussion on the possibility of improving the level of leanness.
A Descriptive Study Of Graduate Information Systems Curriculums

The purpose of this study was to conduct a review of courses currently offered in Information Systems (IS) graduate programs across the United States and compare course offerings to the MSIS 2006 Curriculum Model. The review was limited to programs offered in Colleges of Business. While MSIS 2006 is a valuable tool in designing and updating IS curriculums, results show that the model is not followed closely by universities reviewed in this research. Six of the eleven required courses from MSIS 2006 were not taught at all as full courses at any university reviewed. The five required courses from MSIS 2006 currently offered are Database, Data Communications, Systems Analysis & Design, Enterprise Systems and Project Management. Beyond these five, there is a wide variety of courses being offered.
Influence of Corporate Governance on Performance in Public Hospitals in Embu County, Kenya

Corporate governance is important to the performance of Public Hospitals (PHs) all over the world. This study investigated the Influence of Corporate Governance on Performance in PHs in Embu County, Kenya. The objective of the study was to assess how board characteristics influence performance in PHs in Embu County. The study’s main problem was to assess the performance in PHs using level of customer satisfaction, level of employees’ satisfaction and efficiency. Given that there is minimal research in corporate governance on management of PHs especially in Embu County, the study addressed challenges faced by management, thus helping formulate policies and strategic guidance for County Governments (CGs). The Stewardship Leadership Theory and Organizational Leadership Style were used to develop the theoretical framework on corporate governance. The information was gathered from 140 respondents using questionnaires. Quantitative data was analyzed using Descriptive Statistics whereas Qualitative data was analyzed using Content Analysis Method. The findings were then recapitulated to ascertain whether PHs have put in place policies and guidelines that conduct best practices of corporate governance. Some of the outcome were; PHs complied with the application of corporate governance but failed to implement it fully; the PHs adhered to most of the regulations and government policies but failed to fully adhere to corporate governance guidelines on board characteristics. Finally, the summary and recommendations were then prepared for policy formulation and future use in research on corporate governance on performance in PHs in Embu County, Kenya and globally.
High-Accuracy Determination of Potassium and Selenium in Human Serum by Two-Step Isotope Dilution ICPMS

A high-accuracy measurement technique for determining potassium and selenium in human serum was developed by using two-step Isotope Dilution Inductively Coupled Plasma-Mass Spectrometry (ICPMS) in this research. A more accessible method of the quadrupole ICPMS was employed in this research to achieve an equally high accuracy which had been achieved by a much more expensive method, namely, high-resolution sector field ICPMS (SF-ICPMS), with a comparatively easy and simple operation. In addition, we have evaluated the uncertainty of this method. The results showed that the determination limits of potassium and selenium in serum were 0.8 mg/kg and 2.7 μg/kg, respectively, and the precision for both measurements was lower than 0.2% and 0.7%. The measurement, when employed to measure potassium and selenium in standard materials NIST956D, NIST909C, and GBW09152, had caused a maximum deviation of less than 0.9%, within the stated uncertainty range of standard materials. The RELA international inter-laboratory comparisons of potassium in serum in 2018 conducted by our laboratory also yielded a satisfactory result.
Reducing Leakage Current and Improving SRAM Cell Stability using Independent-Gate Finfet Technology Over Conventional CMOS Technology

In VLSI technology conventional CMOS transistors are continuously scaling down to obtain faster speed of devices and very large scale integrated circuits. But the main drawbacks of CMOS scaling are high leakage current and heavy channel doping. So using CMOS SRAM beyond 45nm cell stability and controlling leakage current are becoming difficult in today's fast low power applications. FinFET may be an alternative of conventional CMOS transistor. In this paper independent double -gate FINFET structure based SRAM 6-Tcell has been proposed to controlling leakage current and improving SRAM cell stability. By adjusting threshold voltage (V t ) without affecting cell ratio we can reduce leakage current so that power during off state of transistor. In conventional CMOS due to heavy channel doping carrier mobilities are reduced which also increases process variations. In independent double gate FINFET technology, two separate gates are used. Threshold voltage of one gate can be altered by varying the voltage at the other gate. In this technology nearly intrinsic channel is used so carrier mobilities will be higher which results in higher speed of devices. Using the thin silicon fin, ratio of I ON /I OFF can also be increased. Due to vertical gate, there will no overlapping between source-gate and drain-gate so depletion and junction capacitances will be effectively eliminated. Wiring delay and bitline capacitance of SRAM will also be reduced.
Human-centred design: An emergent conceptual model

Understanding human needs and how design responds to human needs are essential for human-centred design (HCD). By combining Maslow’s hierarchy of needs model and Kuthe’s “design and society” model, this paper proposes a conceptual model of humancentred design which marries psychology and sociology in investigating the relationship between design and human needs. The study reveals a tendency that design evolution responds to the hierarchy of human needs. Nowadays design tends to care for more levels of human needs.
Adjunctive simvastatin treatment in schizophrenia patients; a double blind randomized and placebo controlled trial

Introduction: Statins such as simvastatin are recently introduced as agents that may have beneficial effects in schizophrenia regarding their prominent anti-inflammatory properties. Objectives: This study was designed to evaluate the effects of simvastatin on schizophrenia symptoms. Patients and Methods: In a double-blinded randomized clinical trial, 40 hospitalized schizophrenia patients (according to the DSM-IV-TR criteria) were studied for 6 weeks. One group of the patients (n=20) received simvastatin (with the dose of 40 mg/d) and the other group received (n=20) placebo. The patients were evaluated by the Positive and Negative Syndrome Scale (PANSS) for schizophrenia symptoms. Data were analyzed with mixed model repeated measure ANOVA, t test, and χ2 test or Fischer’s exact test by SPSS software. The significant cutoff was considered at P<0.05. Results: The mean age of the patients was 34.05±9.74 years and 50% of them were men. There was not a significant difference between the two groups regarding negative symptoms reduction. Conclusion: Our study demonstrated that adding simvastatin on atypical antipsychotic treatment had no significant beneficial effects on the negative and positive symptoms in patients with schizophrenia disorder. Trial Registration: The trial protocol was approved by the Iranian Registry of Clinical Trials (identifier: IRCT2017052034046N1; https://en.irct.ir/trial/26134, ethical code; ETH-457).
A New PSO-RBF Model for Groundwater Quality Assessment

There are three adjustable parameters in the radial basis function, the center of the basis function cj, the width parameter and the output unit weight wj. Through optimization the parameters of the radial basis function by Particle swarm optimization algorithm, a neural network model of underground water is generated, which is used to study the grade of underground water in the ten monitoring points of the black dragon hole. By applying the PSO-RBF model to underground water assessment in the ten monitoring points of the black dragon hole, the results of this evaluation, which correspond with the real conditions, are basically in accord with those obtained by other evaluation methods, and also show the practicability to groundwater quality assessment.
From axe to awe: assessing the co-effects of awe and authenticity on industrial heritage tourism

ABSTRACT This study aims to fill the current research gap on industrial heritage tourism, which is boasting a fast galvanizing and very current market niche, by systematically modelling and evaluating the dimensionality of the experience quality of industrial heritage tourists, with the incorporation of the variables of awe experience, authenticity experience, perceived value and behavioural intentions. An empirical study is conducted on visitors to the Mt. Tangshan Quarry Park in east China, with its mixed and contested expressions and presentations of intact axed scars left to nature, as against awed economic and socio-cultural revitalization and redemption. Study results reveal that the awe experience performs a full mediating effect between authenticity experience and experience quality, while no mediating effect was found between experience quality and behavioural intentions. This study contributes to understanding and utilization of industrial heritage sites as icons for economic and socio-cultural rebirth and rejuvenation availed by tourism development.