Miracle-dz/UniFAR-FTUs huggingface dataset:
Missing data in bioarchaeology II: A test of ordinal and continuous data imputation

Abstract Objectives Previous research has shown that while missing data are common in bioarchaeological studies, they are seldom handled using statistically rigorous methods. The primary objective of this article is to evaluate the ability of imputation to manage missing data and encourage the use of advanced statistical methods in bioarchaeology and paleopathology. An overview of missing data management in biological anthropology is provided, followed by a test of imputation and deletion methods for handling missing data. Materials and Methods Missing data were simulated on complete datasets of ordinal (n = 287) and continuous (n = 369) bioarchaeological data. Missing values were imputed using five imputation methods (mean, predictive mean matching, random forest, expectation maximization, and stochastic regression) and the success of each at obtaining the parameters of the original dataset compared with pairwise and listwise deletion. Results In all instances, listwise deletion was least successful at approximating the original parameters. Imputation of continuous data was more effective than ordinal data. Overall, no one method performed best and the amount of missing data proved a stronger predictor of imputation success. Discussion These findings support the use of imputation methods over deletion for handling missing bioarchaeological and paleopathology data, especially when the data are continuous. Whereas deletion methods reduce sample size, imputation maintains sample size, improving statistical power and preventing bias from being introduced into the dataset.
Substitutional Sodium Doping on Tungsten Ditelluride: A First-principles Study

Methylation at O6 atom of guanine is a type of DNA damage which can cause a cancer. This damage at O6 atom of guanine in a DNA can be transferred to SG atom of cysteine in O6-alkylguanine-DNA alkyltransferase (AGT). Flipping out of methylated guanine from its base stack is essential to give off the methyl adduct (CH3) to AGT. AGT receives the methyl adduct at cysteine leaving guanine demethylated, but still in flipped out orientation. The repair mechanism of DNA would be completed only when the extrahelically flipped guanine returns back into the base stack, which is considered as the final step of the DNA repair mechanism. Here, the intrahelical flipping mechanism of repaired guanine has been studied. The work is further extended to examine the stability of hydrogen bonds between guanine and its pair partner cytosine. The overall result shows that intrahelical rotation of repaired guanine is possible and the base pairing is stable as the ordinary hydrogen bonding. BIBECHANA 19(2022)184-194
Integrated Antitumor Activities of Cellular Immunotherapy with CIK Lymphocytes and Interferons against KIT/PDGFRA Wild Type GIST

Gastrointestinal stromal tumors (GISTs) are rare, mesenchymal tumors of the gastrointestinal tract, characterized by either KIT or PDGFRA mutation in about 85% of cases. KIT/PDGFRA wild type gastrointestinal stromal tumors (wtGIST) account for the remaining 15% of GIST and represent an unmet medical need: their prevalence and potential medical vulnerabilities are not completely defined, and effective therapeutic strategies are still lacking. In this study we set a patient-derived preclinical model of wtGIST to investigate their phenotypic features, along with their susceptibility to cellular immunotherapy with cytokine-induced killer lymphocytes (CIK) and interferons (IFN). We generated 11 wtGIST primary cell lines (wtGISTc). The main CIK ligands (MIC A/B; ULBPs), along with PD-L1/2, were expressed by wtGISTc and the expression of HLA-I molecules was preserved. Patient-derived CIK were capable of intense killing in vitro against wtGISTc resistant to both imatinib and sunitinib. We found that CIK produce a high level of granzyme B, IFNα and IFNγ. CIK-conditioned supernatant was responsible for part of the observed tumoricidal effect, along with positive bystander modulatory activities enhancing the expression of PD-L1/2 and HLA-I molecules. IFNα, but not In, had direct antitumor effects on 50% (4/8) of TKI-resistant wtGISTc, positively correlated with the tumor expression of IFN receptors. wtGIST cells that survived IFNα were still sensitive to CIK immunotherapy. Our data support the exploration of CIK immunotherapy in clinical studies for TKI-resistant wtGIST, proposing reevaluation for IFNα within this challenging setting.
MUZAKI BEHAVIOR IN PAYING ZAKAT THROUGH THE APPLICATION OF THE UNIFIED THEORY MODEL ACCEPTANCE AND USE OF TECHNOLOGY IN JAKARTA PROVINCE

This paper investigated the intents and behavior of muzakki who pay zakat through e-zakat using the Unified Theory of Acceptance and Use of Technology (UTAUT). In DKI Jakarta, the study was done. This article utilizes sampling convenience. The research data were collected using a questionnaire-based survey. Using SmartPLS 3.0, route analysis serves as a statistical instrument for evaluating hypotheses. The findings indicated that neither the performance expectation variable nor the social influence variable substantially affected the desire to use e-zakat. The variable business expectation had a substantial beneficial impact on both the willingness to use e-zakat and the conditions that allow for a substantial beneficial impact on e-zakat use behavior.
Investigating the effect of humility of Muslim leaders on the moral behaviours of followers and spirituality at work in Islamic society

, identifying and correcting problems and paying rewards or punishments. Leadership skills also play an important role in managing deviant behaviours (Fleming 2004). Researchers believe that leaders’ humility towards employees occurs when employees understand that leaders value their participation and care about their well-being, interests and comfort, because leaders are the Organisations are increasingly involved in what they call ‘ethical dilemmas’, that is, the conditions under which wrongdoing and righteous deeds must be defined once again because the line between right and wrong has blurred more than ever. In general, human beings have special moral characteristics in the individual and personality dimension that shape their thoughts, speech and behaviour. It is possible that the same people in the same position and organisation could be affected differently, and their ideas, speech and behaviour affect the efficiency and effectiveness of the organisation. Ethics can have positive or negative consequences at each organisational level. One of the effective factors on the occurrence of employees’ ethical behaviours is the role of spirituality in the work environment and humility of leaders. The purpose of this study is to investigate the effect of humility of Muslim leaders on the moral behaviours of followers and spirituality at work in Islamic society. The statistical population of the study was 370 Muslim employees of International Islamic University Malaysia. After distributing the questionnaires among the statistical population, 352 questionnaires were returned. The validity of the questionnaires was confirmed by the content validity method, and its reliability was confirmed by Cronbach’s alpha. In this research, the structural equation modeling approach and Amos software were used to analyse the data. All hypotheses were confirmed at a 95 % significance level. The results showed that the humility of leaders has a positive and significant effect on spirituality in the workplace and work ethic of followers. Spirituality in the workplace has also a positive effect on employees’ work ethic. Contribution: It is recommended that the officials of organisations should pay attention to spirituality in the workplace and the humility of managers and supervisors towards employees in order to promote work ethics. Further, it can be concluded that organisations can increase the ethical behaviours of employees by promoting the components of organisational spirituality.
10 Gbps all silicon APD optical receiver

Summary form only given. In this paper, we report an all silicon optical receiver operating at 10 Gbps. A high quantum efficiency-bandwidth product was achieved by operating the photodiode in the avalanche regime. Planar p-i-n photodiodes were fabricated using standard CMOS technology on commercially available 2 /spl mu/m SOI substrates. The photodiodes exhibited 3 dB optical bandwidth greater than 8 GHz. At higher bias, avalanche gain was observed. In this work, the photodiode was wire-bonded to a 10 Gbps transimpedance amplifier (TIA).
Diagnosis of Histopathological Images to Distinguish Types of Malignant Lymphomas Using Hybrid Techniques Based on Fusion Features

Malignant lymphoma is one of the types of malignant tumors that can lead to death. The diagnostic method for identifying malignant lymphoma is a histopathological analysis of lymphoma tissue images. Because of the similar morphological characteristics of the lymphoma types, it is difficult for doctors and specialists to manually distinguish the types of lymphomas. Therefore, deep and automated learning techniques aim to solve this problem and help clinicians reconsider their diagnostic decisions. Because of the similarity of the morphological characteristics between lymphoma types, this study aimed to extract features using various algorithms and deep learning models and combine them together into feature vectors. Two datasets have been applied, each with two different systems for the reliable diagnosis of malignant lymphoma. The first system was a hybrid system between DenseNet-121 and ResNet-50 to extract deep features and reduce their dimensions by the principal component analysis (PCA) method, using the support vector machine (SVM) algorithm for classifying low-dimensional deep features. The second system was based on extracting the features using DenseNet-121 and ResNet-50 and combining them with the hand-crafted features extracted by gray level co-occurrence matrix (GLCM), fuzzy color histogram (FCH), discrete wavelet transform (DWT), and local binary pattern (LBP) algorithms and classifying them using a feed-forward neural network (FFNN) classifier. All systems achieved superior results in diagnosing the two datasets of malignant lymphomas. An FFNN classifier with features of ResNet-50 and hand-crafted features reached an accuracy of 99.5%, specificity of 100%, sensitivity of 99.33%, and AUC of 99.86% for the first dataset. In contrast, the same technique reached 100% for all measures to diagnose the second dataset.
Flocking of Multiagent Systems With Nonuniform and Nonconvex Input Constraints

This article investigates the nonuniform and nonconvex input-constrained flocking control problem of continuous-time multiagent systems. A distributed flocking control algorithm is proposed for each agent using the local information from its neighbor agents subject to nonuniform and nonconvex control constraints. Based on a constraint scaling factor and a specific coordinate transformation, a Lyapunov function is constructed to address the nonlinearities caused by input constraints. It is proved that all agents from an explicitly specified region of initial states eventually converge to a common point with the same velocity, while each agent's inputs remain within its own constrained nonconvex set. A simulation example is given to demonstrate the effectiveness of the theoretical results.
Peripheral Blood DNA Methylation Profiles Do Not Predict Endoscopic Post-Operative Recurrence in Crohn’s Disease Patients

Prediction of endoscopic post-operative recurrence (POR) in Crohn’s disease (CD) patients following ileocolonic resection (ICR) using clinical risk factors alone has thus far been inadequate. While peripheral blood leukocyte (PBL) DNA methylation has shown promise as a tool for predicting recurrence in cancer, no data in CD patients exists. Therefore, this study explored the association and predictive value of PBL DNA methylation in CD patients following ICR. From a cohort of 117 CD patients undergoing ICR, epigenome-wide PBL methylation profiles from 25 carefully selected patients presenting either clear endoscopic remission (n = 12) or severe recurrence (n = 13) were assessed using the Illumina MethylationEPIC (850K) array. No statistically significant differentially methylated positions (DMPs) or regions (DMRs) associated with endoscopic POR were identified (FDR p ≤ 0.05), further evidenced by the low accuracy (0.625) following elastic net classification analysis. Nonetheless, interrogating the most significant differences in methylation suggested POR-associated hypermethylation in the MBNL1, RAB29 and LEPR genes, respectively, which are involved in intestinal fibrosis, inflammation and wound healing. Notably, we observed a higher estimated proportion of monocytes in endoscopic POR compared to remission. Altogether, we observed limited differences in the genome-wide DNA methylome among CD patients with and without endoscopic POR. We therefore conclude that PBL DNA methylation is not a feasible predictive tool in post-operative CD.
Geometry of Metrics

During the past thirty years hyperbolic type metrics have become popular tools also in modern mapping theory, e.g., in the study of quasiconformal and quasiregular maps in the euclidean $n$-space. We study here several metrics that one way or another are related to modern mapping theory and point out many open problems dealing with the geometry of such metrics.
Rotational dynamics of rod particles in fluid flows

Rotational dynamics of rod particles in fluid flows Shima ParsaMoghaddam, Ph.D. Wesleyan University May 2013 The primary aim of this research is to study the dynamics of rods in fluid flows, quantify the alignment of rods with the flow and the effects of alignment on the rotation rates. We perform experimental measurements of the rotation of rods in three-dimensional turbulence and resolve the rotational properties. In a 2D chaotic flow we measured the translational and rotational dynamics of rods along with the velocity of the carrier flow. Rods are strongly aligned with the stretching direction of the Cauchy-Green deformation tensor. We report the first three-dimensional measurements of the rotational dynamics of rod-like particles as they are advected in a turbulent fluid flow. Tracer rods preferentially sample the flow since their orientations become correlated with the velocity gradient tensor. The probability distribution of the mean square rotation rate has a long tail which implies the presence of rare events with large rotation
SARS-CoV-2 Production, Purification Methods and UV Inactivation for Proteomics and Structural Studies

Severe acute respiratory syndrome coronavirus-2 is the causative agent of COVID-19. During the pandemic of 2019–2022, at least 500 million have been infected and over 6.3 million people have died from COVID-19. The virus is pleomorphic, and due to its pathogenicity is often handled in very restrictive biosafety containments laboratories. We developed two effective and rapid purification methods followed by UV inactivation that allow easy downstream handling of the virus. We monitored the purification through titering, sequencing, mass spectrometry and electron cryogenic microscopy. Although pelleting through a sucrose cushion, followed by gentle resuspension overnight gave the best particle recovery, infectivity decreased, and the purity was significantly worse than if using the size exclusion resin Capto Core. Capto Core can be used in batch mode, and was seven times faster than the pelleting method, obviating the need for ultracentrifugation in the containment laboratory, but resulting in a dilute virus. UV inactivation was readily optimized to allow handling of the inactivated samples under standard operating conditions. When containment laboratory space is limited, we recommend the use of Capto Core for purification and UV for inactivation as a simple, rapid workflow prior, for instance, to electron cryogenic microscopy or cell activation experiments.
The Role of Slab Steps on Tectonic Loading Along Subduction Zones: Inferences on the Seismotectonics of the Sunda Convergent Margin

How seismotectonics of convergent margins reconciles with the force balance of subduction is contentious. The comparison of seismotectonics and available slab pull forces along the Sunda convergent margin shows an enigmatic inverse relationship: upper plate thickening and seismicity magnitude are highest along Sumatra and Andaman, where the slab is shorter than ∼300 km; conversely, these are negligible along the Java segment, where the slab reaches deeper, ∼660 km. Using numerical models, we test the role of such slab pull gradients in the force balance of subduction in three‐dimensions, where the slab depth, and therefore its net pull, varies along the trench. We show that in the presence of a “slab step,” the deeper slab drives the convergence of the rigid plate, causing upper plate compression and trench advance in the neighboring trench segments, where a short slab may have no pull to subduct the incoming plate. While neglecting convergence obliquity, the simplified models show relevant along‐trench variations of coupling, trench rotations, and minor strike‐slip shearing due to the slab step, providing a diagnostic strain pattern, with compression/extension atop the short/long slab and minor strike‐slip, increasing in magnitude with depth difference. The modeled tectonic patterns are compared to Sunda margin deformation across scales, from the Cenozoic tectonics to the seismic strain rates, showing remarkable consistency with deformation gradients from Sumatra to Java, potentially illustrating the contribution of the slab step to the seismotectonics of the region.
A SEARCH FOR H2O MEGAMASERS IN HIGH-z TYPE-2 ACTIVE GALACTIC NUCLEI

We report a search for H2O megamasers in 274 SDSS type-2 active galactic nuclei (AGNs; 0.3 <z< 0.83), half of which can be classified as type-2 quasi-stellar objects (QSOs) from their [O iii] 5007 luminosity, using the Robert C. Byrd Green Bank Telescope (GBT) and the Effelsberg 100 m radio telescope. Apart from the detection of the extremely luminous water vapor megamaser SDSS J080430.99+360718.1, already reported by Barvainis & Antonucci, we do not find any additional line emission. This high rate of nondetections is compared to the water maser luminosity function created from the 78 water maser galaxies known to date and its extrapolation toward the higher luminosities of “gigamasers” that we would have been able to detect given the sensitivity of our survey. The properties of the known water masers are summarized and discussed with respect to the nature of high-z type-2 AGNs and megamasers in general. In the Appendix, we list 173 additional objects (mainly radio galaxies, but also QSOs and galaxies) that were observed with the GBT, the Effelsberg 100 m radio telescope, or Arecibo Observatory without leading to the detection of water maser emission.
SECI Model Combined with ISO 9001 2015 to Support Organizational KM for Manual Assembly Manufacturing Operations

In a large number of industrial sectors, manual assembly manufacturing operations highly engage tacit knowledge at an individual level. Companies in these sectors need to effectively manage organizational knowledge since it represents a real performance and sustainability lever. Although knowledge management (KM) specialists developed several models, these latter remain difficult to implement due to several barriers and limitations related to industrial reality and models ambiguity. This paper proposes an organizational knowledge management (OKM) framework for manual assembly manufacturing operations that is based on ISO 9001:2015 and SECI conversion cycle. This framework offers guidance for implementing a KM approach within the quality management system (QMS) allows to manage knowledge differently with regards to its tacitness level and overcomes many of the most common KM limitations. An experimental application based on a single case research design in an aeronautical assembly company is conducted to confirm the applicability and effectiveness of the framework suggested.
Delayed metal recycling in galaxies: the inefficiency of cold gas enrichment in colliding supershell simulations

The fate of metals ejected by young OB associations into the Interstellar Medium (ISM) is investigated numerically. In particular, we study the enrichment of the cold gas phase, which is the material that forms molecular clouds. Following previous work, the expansion and collision of two supershells in a diffuse ISM is simulated, in this case also introducing an advected quantity which represents the metals expelled by the young stars. We adopt the simplest possible approach, not differentiating between metals coming from stellar winds and those coming from supernovae. Even though the hot, diffuse phase of the ISM receives a significant amount of metals from the stars, the cold phase is efficiently shielded, with very little metal enrichment. Significant enrichment of the cold ISM will therefore be delayed by at least the cooling time of this hot phase. No variations in cloud metallicity with distance from the OB association or with direction are found, which means that the shell collision does little to enhance the metallicity of the cold clumps. We conclude that the stellar generation that forms out of molecular structures, triggered by shell collisions cannot be significantly enriched.
Concentrations of CH4, CO, CO2, H2, H2O and N2O in the upper stratosphere

Abstract On 23 May 1973 a cryogenic air sampler was flown on an Aerobee rocket from White Sands Missile Range. A large air sample was collected between 40 and 50 km altitude and successfully recovered for water vapor and trace gas analysis. The results were as follows: water vapor, 4.0+1.3−0.9 ppmV; methane, 0.37±0.01 ppmV; molecular hydrogen, 0.47±0.02 ppmV; carbon monoxide, 0.05±0.01ppmV; carbon dioxide, 316.2±2.8 ppmV; and nitrous oxide, 3±7ppb.
Percolative model of the effect of disorder on the resistive peak broadening in La2/3Ca1/3MnO3 near the metal-insulator transition

The effect of the lattice disorder on the resistivity of La1−xCaxMnO3 (LCMO) near x=13 at the metal-insulator transition was studied by using a percolation model. The percolation model was applied to calculate the temperature dependence of the resistivity ρ(T) of the mixed state, where metallic ferromagnetic and insulating paramagnetic clusters simultaneously exist. The temperature dependence of the fraction of the metallic phase was obtained by assuming a Gaussian distribution of random transition temperatures, whose width increases with an increasing lattice disorder. The resistivity ρ(T) calculated from the model reproduces well the experimental ones for LCMO crystals and disordered films.The effect of the lattice disorder on the resistivity of La1−xCaxMnO3 (LCMO) near x=13 at the metal-insulator transition was studied by using a percolation model. The percolation model was applied to calculate the temperature dependence of the resistivity ρ(T) of the mixed state, where metallic ferromagnetic and insulating paramagnetic clusters simultaneously exist. The temperature dependence of the fraction of the metallic phase was obtained by assuming a Gaussian distribution of random transition temperatures, whose width increases with an increasing lattice disorder. The resistivity ρ(T) calculated from the model reproduces well the experimental ones for LCMO crystals and disordered films.