Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunolocalization of electroneutral Na-HCO3

HENRIK VORUM, TAE-HWAN KWON, CHRISTIAAN FULTON, BRIAN SIMONSEN, INYEONG CHOI, WALTER BORON, ARVID B. MAUNSBACH, SØREN NIELSEN, AND CHRISTIAN AALKJÆR Department of Medical Biochemistry, Department of Cell Biology, Institute of Anatomy, and Department of Physiology, University of Aarhus, DK-8000 Aarhus C, Denmark; and Department of Cellular and Molecular Physiology, Yale University, New Haven, Connecticut 06520
Part Biotechnology and genetics EFFECT OF PHYTONUTRIENT ‘VITASTIM’ ON CHICKEN MUCOSAL IMMUNITY AGAINST LOW PATHOGENIC AVIAN INFLUENZA VIRUS H4N6

Summary. The study of immunostimulating phytogenous preparation ‘Vitastim’ influence on chickens infected by subtype H4N6 avian influenza virus was provided. It was determined, that preparation usage is more actively influences on humoral mediators of immune reaction and proliferation activity of spleen lymphocytes under conditions of low pathogenic avian influenza. This is evidenced by an increase in proliferative activity of chicken splenocytes at 5–14 days and an increase in production of NO during 14 days of the experiment. According to the quantitative real-time PCR results the expression of IL-2, IL-13, IL-17α in peripheral blood was effectively increasing with the promotion of enhances anti-viral activity. Due to the immunohistochemical studies of chicken it was found the influence of the phytonutrient ‘Vitastim’ on humoral immune system by registration of high levels of IgM, IgG, IgA. Cell immunity was stimulated by the ‘Vitastim’, however, as evidenced by the low levels of CD4, macrophages, IL-2, IL-15 in chickens of experimental groups compared to the intact birds, cell immunity does not play a significant role in the pathogenesis of LPAI. The phytonutrient ‘Vitastim’ produces moderated effect on the cell immune system at influenza virus infection with stimulation of IL-2, IL-4, IL-17, IFN-γ expression with irregular tendency in different observation periods.
SOME PROPERTIES OF THE QUOTIENT SPACE ( LI ( Td ) / H ( Da ) )

Let D be the unit disc of the complex plane and T the unit circle equipped with normalized Lebesgue measure. Let d be a positive integer. We denote by D and T respectively the products of d copies of D and T. They are respectively the d-disc and d-torus. T is equipped with the product measure dm. Let 0 < p < o. We denote by HP(Dd) the classical Hardy space in the polydisc Dd. If p < 0% this is the space of the analytic functions f in D such that
Funding and Motivational Factors across Industries

Purpose The purpose of this paper is to investigate the motivational factors for participation in collaborative consumption across industries and if specific factors attracts funding. This will be done as an attempt to extend current research within sharing economy regarding what factors to consider when attracting funding. Method and Methodology Utilizing a deductive approach, the research questions connect motivational factors for participation with funding of industries within the sharing economy. Secondary data containing 776 funding rounds were analysed through univariate and bivariate analyses and linked to 40 935 observations of motivational factors for participation. Findings The findings entail how some motivational factors for participation in the sharing economy can be applicable to all investigated industries, while others are industry specific. The study thus suggest that the sharing economy cannot be viewed as one coherent industry and motivational factors should not be cross-sector generalized. Contribution The study contributes with a theoretical implication in the way it bridges the existing gap by dividing the sharing economy into different industries and connect the specific motivational factors underlying the possibility to attract funding. Furthermore, a practical implication suggests that companies can use these findings as a guideline to attract consumers and ultimately funding.
Automatic Regions-of-Interest Selection based on Pearson’s Correlation Coefficient

—Navigation of a Mobile Robot is based on its interaction with the environment, through information acquired by sensors. Particularly for Mobile Robot navigation in unknown environment, the type and number of sensors determines the data volume necessary to process and compose the image from the environment. Nevertheless, the excess of information imposes a great computational cost in data processing. Taking into account the temporal coherence between consecutive frames, a Discarding Criteria methodology based on Pearson’s Correlation Coefficient (PCC) was proposed and applied as a Dynamic Power Management solution to a robotic visual-machine perception. In this context, this work proposes an environment observer method based on PCC that instead of processing all image pixels, it selects automatically only the regions-of-interest (ROI) and processes it in real time in order to perform a task: road detection and obstacle avoidance. This real-time visual perception system has been evaluated from real data obtained by two experimental platforms.
OTT_A_232526 11777..11791

Junpeng Ma Wei Chen Ke Wang Kaibing Tian Qi Li 3 Tianna Zhao Liwei Zhang Liang Wang Zhen Wu Junting Zhang 1,5,6 1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, People’s Republic of China; 3China National Clinical Research Center for Neurological Diseases, Beijing, People’s Republic of China; 4Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 5Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, People’s Republic of China; 6Beijing Key Laboratory of Brian Tumor, Beijing, People’s Republic of China Purpose: The roles of T (brachyury) isoforms in chordomas remain unclear. This study aimed to investigate the different roles and mechanisms of them in chordomas. Patients and methods: The expression of T isoformsmRNAs in 57 chordomas was assessed, and a prognosis analysis was conducted. Cell apoptosis, proliferation and cell cycle assays were performed after specific T isoform mRNA knockdown. Whole-transcriptome sequencing, Gene Set Enrichment Analysis, Gene Ontology analysis, Kyoto Encyclopedia of Genes and Genomes analysis and competing endogenous RNA (ceRNA) analysis were conducted. Results: As revealed in this study, the T-long isoform was a significant risk factor (hazard ratio [HR], 1.09; P=0.018) and the T-short isoform was a protective factor (HR, 0.24; P=0.012) associated with tumor recurrence. After T-long isoform knockdown, the cell cycle was arrested at G0/G1 phase and cell proliferation was significantly inhibited. A bioinformatic analysis revealed that the upregulation of H19, P21 and GADD45B; downregulation of SKP2 and CDK2; and accompanying changes in the P53 signaling pathway consistently contributed to G0/G1 arrest. After T-short isoform knockdown, the cell cycle was arrested at G2/M phase and cell apoptosis tended to increase slightly (P=0.067). The upregulation of YWHAZ and downregulation of E2F1 and its target genes might contribute to cell cycle arrest in G2/M phase and apoptosis. In addition, the ceRNA network, consisting of long noncoding RNAs, mRNAs and microRNAs, was established. Conclusion: The T-long isoform was a risk factor and the T-short isoform was a protective factor for chordoma recurrence. In addition, the cell cycle was the main target of T isoforms knockdown, and the changes in the downstream transcriptome may contribute to the different effects of specific T isoform knockdown on the changes in the cell cycle distributions and apoptosis and proliferation of chordoma cells.
Sequential streaming of speech sounds based on position cues: Effect of head position and spatial attention

Torben Pastore and Willam A Yost Psychoacoustic lab, Speech and Hearing Sciences Arizona State University PO Box 870192 Tempe AZ 85287-0102 (Dated: July 11, 2019) This scientific report has been written during the visiting period of Nicolas Grimault at ASU from January the 1st to March the 29th 2018. The purpose of this document is to report preliminary data about sequential streaming based on position cues and spatial attention.
Good Practice in Large-Scale Learning for Image Classification

We benchmark several SVM objective functions for large-scale image classification. We consider one-versus-rest, multiclass, ranking, and weighted approximate ranking SVMs. A comparison of online and batch methods for optimizing the objectives shows that online methods perform as well as batch methods in terms of classification accuracy, but with a significant gain in training speed. Using stochastic gradient descent, we can scale the training to millions of images and thousands of classes. Our experimental evaluation shows that ranking-based algorithms do not outperform the one-versus-rest strategy when a large number of training examples are used. Furthermore, the gap in accuracy between the different algorithms shrinks as the dimension of the features increases. We also show that learning through cross-validation the optimal rebalancing of positive and negative examples can result in a significant improvement for the one-versus-rest strategy. Finally, early stopping can be used as an effective regularization strategy when training with online algorithms. Following these "good practices," we were able to improve the state of the art on a large subset of 10K classes and 9M images of ImageNet from 16.7 percent Top-1 accuracy to 19.1 percent.
Title Surface electronic structure of the topological Kondo-insulator candidate correlated electron system SmB 6

The Kondo insulator SmB6 has long been known to exhibit low temperature transport anomalies whose origin is of great interest. Here we uniquely access the surface electronic structure of the anomalous transport regime by combining state-of-the-art laserand synchrotron-based angle-resolved photoemission techniques. We observe clear in-gap states (up to ∼ 4 meV), whose temperature dependence is contingent upon the Kondo gap formation. In addition, our observed in-gap Fermi surface oddness tied with the Kramers’ points topology, their coexistence with the two-dimensional transport anomaly in the Kondo hybridization regime, as well as their robustness against thermal recycling, taken together, collectively provide by-far the strongest evidence for protected surface metallicity with a Fermi surface whose topology is consistent with the theoretically predicted topological surface Fermi surface. Our observations of systematic surface electronic structure provide the fundamental electronic parameters for the anomalous Kondo ground state of the correlated electron material SmB6.
Crop water and irrigation requirements of some selected crops in southwestern hydrological zone of Nigeria

This study was carried out to determine the crop water and irrigation requirement of some selected crops in southwestern Nigeria. The crops are cucumber, water melon, maize, groundnut, eggplant and tomato. Irrigation requirement and crop coefficient for each crops were determined from the interrelationships of the evapotranspiration, soil type, bulk density, field capacity and the effective root zone of the crops at the selected locations using CROPWAT for windows version 8. Soil parameters used for analysis were determined from laboratory experiment. The crop evapotranspiration and water requirement for cucumber varied from 2.52 to 7.21mm/day and 17 to 73.2mm/dec, respectively, for maize from 1.36 to 6.35mm/day and 5.1 to 63.5mm/dec respectively, for watermelon varied from 2.59 to 6.67mm/day and 25.9 to 73.3mm/dec respectively, for eggplant varied from 1.92 to 6.35 mm/day and 15.9 to 64.4mm/dec respectively. The irrigation requirement for water melon and cucumber recorded the highest value of 461.6 and 497.4mm/dec respectively, an indication that the two crops require more water for physiological activities. The reduction in the values of crop coefficient was observed during the study which could be attributed to the reduction in evapotranspiration at the late stage of growth. The findings also showed that known quantities of irrigation water could be used in producing crops optimally.
Trehalose-6-phosphatePhosphatase fromMycobacterium tuberculosis induceshumoral and cellular immune responses

Trehalose-6-phosphate phosphatase is an enzyme strictly essential for the growth of mycobacteria. Subcellular fractionation of Mycobacterium tuberculosis and M. bovis bacillus Calmette-Guérin (BCG) located the trehalose-6-phosphate phosphatase in the cell wall and membrane fractions. Trehalose-6-phosphate phosphatase induced an increased Th1-type immune response in mice, characterized by an elevated level of interferon-g in antigen-stimulated splenocyte culture and a strong IgG2a antibody response. The trehalose-6-phosphate phosphatase was recognized by the sera of tuberculosis patients and BCG-vaccinated donors. The mycobacterial trehalose-6-phosphate phosphatase is an immunodominant antigen, and it may be a candidate for vaccine development for the control of tuberculosis.
A G ] 4 F eb 2 01 3 Baxter operator formalism for Macdonald polynomials

We develop basic constructions of the Baxter operator formalism for the Macdonald polynomials associated with root systems of type A. Precisely we construct a dual pair of mutually commuting Baxter operators such that the Macdonald polynomials are their common eigenfunctions. The dual pair of Baxter operators is closely related to the dual pair of recursive operators for Macdonald polynomials leading to various families of their integral representations. We also construct the Baxter operator formalism for the q-deformed gll+1-Whittaker functions and the Jack polynomials obtained by degenerations of the Macdonald polynomials associated with the type Al root system. This note provides a generalization of our previous results on the Baxter operator formalism for the Whittaker functions. It was demonstrated previously that Baxter operator formalism for the Whittaker functions has deep connections with representation theory. In particular the Baxter operators should be considered as elements of appropriate spherical Hecke algebras and their eigenvalues are identified with local Archimedean L-factors associated with admissible representations of reductive groups over R. We expect that the Baxter operator formalism for the Macdonald polynomials has an interpretation in representation theory of higher-dimensional arithmetic fields. Introduction A new class of operators acting on eigenfunctions of quantum integrable systems was introduced by Baxter to provide a solution of a class of integrable models [Ba]. These operators commute with quantum Hamiltonians of a quantum integrable system and satisfy difference/differential equations with coefficients expressed through quantum Hamiltonians. The Baxter operators were constructed for many integrable models including periodic Toda chains [PG]. In [GLO1] we introduce Baxter operators for non-periodic gll+1-Toda chains given by oneparameter families of integral operators. We also define dual Baxter operators acting on the spectral variables of Toda chain eigenfunctions. The dual pair of Baxter operators enters a canonical construction of a pair of recursive operators relating eigenfunctions of the gll+1and gllToda chains. This gives rise to various families of integral representations for eigenfunctions. Hence the Baxter operator formalism consisting of a pair of dual Baxter operators, a pair of dual recursive operators provides a complete solution of the Toda chains. One can expect that the Baxter operator formalism can be constructed for a wide class of quantum integrable systems. Note that gll+1-Toda chains can be considered as a degeneration of the quantum integrable system constructed by Ruijsenaars [Ru] and Macdonald [M]. The corresponding quantum Hamiltonians are given by mutually commuting difference operators and their common polynomial eigenfunctions are given by the Macdonald polynomials. In this note we construct Baxter operator formalism for the Macdonald-Ruijsenaars integrable system. This includes a dual
Can graph theory discriminate between aptamer-protein configurations?

Graph theory has been extensively applied in the study of proteins, although few applications still exist on bio-molecules like aptamer-protein complexes, whose structure is in silico obtained. Aptamers represent a challenging field of research, especially for their involvement in therapy, diagnosis and early detection of illness; furthermore, the in vivo procedures to synthetize them are quite expensive and more time-consuming than those in silico. This paper is focused on the question if and how general network parameters are able to anticipate some features of those biomolecules. The rationale resides in the fact that, studying a large set of aptamer-angiopoietin complexes, two different types of conformers are manifest. Both types could be present in a real sample with their relative amount reflecting, in a typical population shift scenario, the affinity of the whole sample.
Current knowledge of Diaporthales (Ascomycota) in Bulgaria

Th e known data on the diversity of the Diaporthales in Bulgaria are summarized and briefl y discussed. For each taxon, the distribution throughout the country along with the literature sources referring to it and the herbarium acronym of the kept specimens are given. Th e information about the anamorphs of some diaporthalean species is also included. Th e species distribution by fl oristic regions is presented in a table.
Nutrient Interactions and Toxicity Various Nondigestible Saccharides Open a Paracellular Calcium Transport Pathway with the Induction of Intracellular Calcium Signaling in Human Intestinal Caco-2 Cells

Ingestion of soluble nondigestible saccharides increases calcium absorption, and it is suggested that paracellular calcium transport contributes to this effect. However, cellular mechanisms and the contribution of active transport have not been clarified. This study examined the effects of 4 nondigestible saccharides, difructose anhydride (DFA) III, DFAIV, fructooligosaccharides, and raffinose, on active and passive calcium transport, permeability of paracellular pathways, and intracellular calcium signaling in a human intestinal Caco-2 cell monolayer. Net, active, and passive calcium transport were evaluated using Ca. Transepithelial electrical resistance (TEER) and transport of lucifer yellow were measured as indicators of paracellular passage in differentiated Caco-2 cell monolayers incubated with 0–100 mmol/L of the various saccharides. The changes in intracellular calcium ion concentrations ([Ca ]i) were measured by fura-2 loading before and after the addition of each saccharide (50 or 100 mmol/L). The addition of 100 mmol/L of each saccharide to the apical medium of the Caco-2 cells enhanced net calcium transport without any changes in active calcium transport. Relative TEER was dose dependently and reversibly decreased by the addition of saccharides, and the decreases in TEER were highly correlated with net calcium transport (P 0.001). Basolateral application of the saccharides had a slight or no effect on indicators of the paracellular pathway. Each saccharide caused an immediate and dose-dependent rise in [Ca ]i in the cells. The 4 nondigestible saccharides increased net calcium transport in the cells via the paracellular route through tight junctions. The rise in [Ca ]i induced by these saccharides may be involved in the opening of tight junctions. J. Nutr. 134: 1935–1941, 2004.
Validation of Short-Term Noise Assessment Procedures: FY16 Summary of Procedures, Progress, and Preliminary Results

Abstract : Army regulations require that installations assess the impacts of training range noise on wildlife and the human community. This work provides a summary of the work performed in fiscal year 2016 for the Environment, Safety and Occupational Health Short-Term Noise Assessment Procedure Demonstration/Validation project. This report describes the procedure used to generate the noise models output dataset, and then it compares that dataset to the benchmark, the Engineer Research and Development Centers Long-Range Sound Propagation dataset. It was found that the models consistently underpredict the measured values. Multiple topics were explored towards identifying possible sources of error. The peak-level calculation algorithm is found to perform adequately, but an alternative method is recommended for future use. Significant meteorological variability is found across the landscape, leading to challenges in estimating the correct propagation class for a particular scenario. A deeper investigation of the propagation class selection algorithm is continuing in FY17. Updates to the noise assessment tools are identified. Throughout this document, procedures used for calculations and analysis are included.
Longitudinal trends in serum ferritin levels and associated factors in a national incident hemodialysis cohort

Background: The rise in serum ferritin levels among US maintenance hemodialysis patients has been attributed to higher intravenous iron administration and other changes in practice. We examined ferritin trends over time in hemodialysis patients and whether iron utilization patterns and other factors [erythropoietin-stimulating agent (ESA) prescribing patterns, inﬂammatory markers] were associated with ferritin trajectory. Methods: In a 5-year (January 2007–December 2011) cohort of 81 864 incident US hemodialysis patients, we examined changes in ferritin averaged over 3-month intervals using linear mixed effects models adjusted for intravenous iron dose, malnutrition and inﬂammatory markers. We then examined ferritin trends across strata of baseline ferritin level, dialysis initiation year, cumulative iron and ESA use in the ﬁrst dialysis year and baseline hemoglobin level. Results: In models adjusted for iron dose, malnutrition and inﬂammation, mean ferritin levels increased over time in the overall cohort and across the three lower baseline ferritin strata. Among patients initiating dialysis in 2007, mean ferritin levels increased sharply in the ﬁrst versus second year of dialysis and again abruptly increased in the ﬁfth year independent of iron dose, malnutrition and inﬂammatory markers; similar trends were observed among patients who initiated dialysis in 2008 and 2009. In analyses stratiﬁed by cumulative iron use, mean ferritin increased among groups receiving iron, but decreased in the no iron group. In analyses stratiﬁed by cumulative ESA dose and baseline hemoglobin, mean ferritin increased over time. Conclusions: While ferritin trends correlated with patterns of iron use, increases in ferritin over time persisted independent of intravenous iron and ESA exposure, malnutrition and inﬂammation.