Miracle-dz/UniFAR-FTUs huggingface dataset:
Biochemical of Phytosterol Oxidation Products Are Absorbed in the Intestinal Lymphatics in Rats but Do Not Accelerate Atherosclerosis in Apolipoprotein E–Deﬁcient Mice 1

Phytosterol oxidation products (oxyphytosterols) are formed during the processing and storage of foods. However, it is unknown whether oxyphytosterols affect human health. To address these issues, we prepared (cid:1) -sitosterol and campesterol oxides, evaluated their lymphatic absorption in rats, and examined the effect of an oxyphytosterol diet on atherosclerosis in apolipoprotein (apo) E–deﬁcient mice. The lymphatic absorption of cholesterol and 6 oxyphytosterols (7 (cid:2) -hydroxy, 7 (cid:1) -hydroxy, (cid:1) -epoxy, (cid:2) -epoxy, dihydroxy, and 7-keto) of (cid:1) -sitos-terol or campesterol was assessed in thoracic duct–cannulated rats fed an AIN-93G–based diet containing 2.5 g of cholesterol, oxyphytosterols, or intact phytosterols per kg. Lymphatic recoveries (on a mass basis) of oxycampesterols (15.9 (cid:1) 2.8%, n (cid:2) 10) and oxysitosterols (9.12 (cid:1) 1.77%, n (cid:2) 10) were higher than for campesterol (5.47 (cid:1) 1.02%, n (cid:2) 12, P (cid:3) 0.05) and (cid:1) -sitosterol (2.16 (cid:1) 0.37%, n (cid:2) 12, P (cid:3) 0.05), but lower than for cholesterol (37.3 (cid:1) 8.3%, n (cid:2) 6, P (cid:3) 0.05). Apo E–deﬁcient mice were fed an AIN-93G–based diet containing 0.2 g oxyphytosterols or intact phytosterols per kg for 9 wk. Diet-derived oxyphytosterols accumulated in the serum, liver, and aorta. Furthermore, the oxyphytosterol diet increased oxycholesterol in the serum compared to the phytosterol diet. However, there was no signiﬁcant difference between the 2 groups in the serum and aortic cholesterol concentration, the lesion area in the aortic root, or 8-iso-prostaglandin F2 (cid:2) concentration in the urine. These results indicate that exogenous oxyphytosterols are well-absorbed and accumulate in the body, but do not promote the development of atherosclerosis in apo E–deﬁcient mice. J. Nutr. 134: 1690–1696, 2004. at m / z 569 (M-181). We used 8-iso-PGF2 (cid:2) -d4 (Cayman Chem- icals) as an internal standard and ions at m / z 573 were monitored. Quantiﬁcation of endogenous 8-iso-PGF2 (cid:2) was accomplished by se- lected ion monitoring analysis of the ratio of m / z 569 to m / z 573. The lower limit of detection (signal-to-noise ratio of 4:1) of 8-isoPGF2 (cid:2) was within the range for 50 (cid:3) L urine. A standard curve was con-structed by adding varying amounts of unlabeled 8-iso-PGF2 (cid:2) to 1 ng of 8-isoPGF2 (cid:2) -d4, and the measured ratio of m / z 569 to m / z 573 and the expected ratio were compared. The standard curve was linear over a 30-fold range in concentration. A concentration of urine 8-iso-PGF2 (cid:2) was expressed as a function of urinary creatine (Wako Pure Chemicals).
HIV_A_255751 295..306

1Mizan Tepi University, College of Health Sciences, Mizan Tefri, Ethiopia; 2Kotebe Metropolitan University, Menelik II College of Medicine and Health Sciences, Addis Ababa, Ethiopia Purpose: After the initiation of highly active antiretroviral therapy (HAART), successful HAART is characterized by an increase in the CD4 count. Several factors affect the CD4 T-cell count. This study aimed to assess the immunological response during HAART and determinants of the current CD4 T-cell count among HIV/AIDS patients on HAART. Patients and Methods: A hospital-based cross-sectional study was conducted from February 1 to April 1, 2017. A total of 423 HIV/AIDS patients on HAART were enrolled using simple random sampling. Descriptive statistics, and bivariate and multiple regression analyses were conducted. Variables with p-value <0.2 in the bivariate analysis were entered in the multiple regression models. p-Values <0.05 and 95% confidence intervals were used to identify determinants of the current CD4 T-cell count. Results: The mean CD4 T-cell count gradually increased until 8 years on HAART but declined thereafter. An increased current CD4 T-cell count was observed among patients with an initial regimen of pediatric d4T-3TC-NVP [β=185.5, 95% CI (8.8, 362.2)] (p=0.040), with increased baseline CD4 T-cell count [β=0.468, 95% CI (0.342, 0.594)] (p<0.0001), and with long duration on HAART [β=18.0, 95% CI (9.9, 26.1)] (p<0.0001), whereas a decreased level of current CD4 T-cell count was observed among males [β=−72.7, 95% CI (−114.5, –30.9)]) (p<0.0001) and those with poor baseline adherence [β=−108.9, 95% CI (−210.9, −7.0)] (p=0.036) and viral load >1000 copies [β=−189.2, 95% CI (−243.5, −134.9)] (p<0.0001). Conclusion: The trend in immunological response was not increased linearly throughout the HAART duration. Sex, type of initial regimen, baseline adherence, baseline CD4 count, viral load, and duration on HAART were independent determinants of current CD4 count. These determinants could be addressed by regular monitoring of HIV patients on HAART, and special attention should be paid to male patients.
Assessment of Olive Pomace and Chicken Manure Compared to Topsin-M70 in Controlling Fusarium Wilt of Lupine with Enhancement of some Yield Components

rganic wastes, a primarily by-products of many industrial activities, include animal manures and olive pomace that were used as compost. The compost-amended soils are the highly induced suppression of numbers of soil-borne pathogens. Olive pomace and chicken manure were used in this study compared to Topsin-M70 for controlling lupine wilt disease caused by Fusarium oxysporum f.sp. lupini under greenhouse and field conditions, Ismailia, Egypt. In general, application of the two olive pomace and chicken manure amendments suppressed Fusarium activity in both seasons (2008/09 and 2009/10) in comparison with Topsin-M70. Under greenhouse conditions, the highest disease reduction (85.7%) and the highest percentage of healthy lupine plants (88%) were recorded due to treatment by olive pomace at the rate of 25% and chicken manure at the rate of 10%. On the other hand, olive pomace and chicken manure compared to the fungicide Topsin-M70 caused a significant increase in root length (RL), plant height (PH), number of branches/ plant (NB), number of pods/plant (NP), and single yield plant (SYP) over the control under green house conditions. The effect of olive pomace and chicken manure on lupine wilt diseases incidence under field conditions was positive, where, crop yields and its components, i.e . PH, NB, NP and 100-seed weight (HSW) were increased in amended plots. Generally, olive pomace and chicken manure enhanced fungal pathogens suppressiveness and reduced the diseases incidence as well as increased seed yield compared to the fungicide Topsin-M70.
A Proposal for Discovering Hotspots Using 3D Coordinates from Geo-tagged Photographs

—A hotspot is an interesting place where many people go for sightseeing. To extract hotspots, most of the existing research applies a density-based clustering algorithm, such as Density-based spatial clustering of applications with noise (DBSCAN) with latitude and longitude as its features. Therefore, the extracted hotspots are visualized as a two-dimensional space. However, large areas, landmarks, and buildings may include high hotspots or multiple hotspots with different altitudes. Therefore, in this research, we propose extracting hotspots based on altitude in addition to latitude and longitude and visualize these extracted hotspots in a three-dimensional space. To use those features, we apply ST-DBSCAN to extract hotspots and discuss the usefulness of extracting hotspots using altitude. In addition, as an application example, we classiﬁed hotspots as shooting spots, observation spots, areas of interest, among others and visualized the results.
Scheduling over scenarios

We consider scheduling problems over scenarios where the goal is to ﬁnd a single assignment of the jobs to the machines which performs well over all scenarios in an explicitly given set. Each scenario is a subset of jobs that must be executed in that scenario. The two objectives that we consider are minimizing the maximum makespan over all scenarios and minimizing the sum of the makespans of all scenarios. For both versions, we give several approximation algorithms and lower bounds on their approximability. We also consider some (easier) special cases. Combinatorial optimization problems un-E
Optimal State Estimation under Observation Budget Constraints

—In this paper, we consider the problem of monitoring an intruder in a setting where the number of opportunities to conduct surveillance is budgeted. Speciﬁcally, we study a problem in which we model the state of an intruder in our system with a Markov chain of ﬁnite state space. These problems are considered in a setting in which we have a hard limit on the number of times we may view the state. We consider the Markov chain together with an associated metric that measures the distance between any two states. We develop a policy to optimally (with respect to the speciﬁed metric) keep track of the state of the chain at each time step over a ﬁnite horizon when we may only observe the chain a limited number of times. The tradeoff captured is the budget for surveillance versus having a more accurate estimate of the state; the decision at each time step is whether or not to use an opportunity to observe the process. We also examine a scenario in which there is a budget constraint as described as well as a cost on observation. Finally, theoretical properties of the solution are presented. Hence, we present the problem of monitoring the state of an intruder using a Markov chain approach and present an optimal policy for estimating the intruder’s state.
VITAMIN D STATUS IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS IN

Vitamin D status is potentially commanded by the similar factors as JIA; vitamin D receptor genotype, ethnically related skin tone and clothes, environmental differences in exposure to ultraviolet B radiation relating to the housing conditions, season, and vitamin D nutritional intake are factors that modulate serum vitamin D levels. For this reasons special awareness had been given to the involvement of vitamin D in good health and well-being. Vitamin D is incriminated in the pathogenesis of autoimmune diseases including, as examples, multiple sclerosis, type 1 diabetes, Crohn‟s disease, and asthma because of its notable role as in inflammation and immune mediation. [8-11]
PMU Measurement-Based Intelligent Strategy for Power System Controlled Islanding

Controlled islanding is an effective remedy to prevent large-area blackouts in a power system under a critically unstable condition. When and where to separate the power system are the essential issues facing controlled islanding. In this paper, both tasks are studied to ensure higher time efficiency and a better post-splitting restoration effect. A transient stability assessment model based on extreme learning machine (ELM) and trajectory fitting (TF) is constructed to determine the start-up criterion for controlled islanding. This model works through prompt stability status judgment with ELM and selective result amendment with TF to ensure that the assessment is both efficient and accurate. Moreover, a splitting surface searching algorithm, subject to minimal power disruption, is proposed for determination of the controlled islanding implementing locations. A highlight of this algorithm is a proposed modified electrical distance concept defined by active power magnitude and reactance on transmission lines that realize a computational burden reduction without feasible solution loss. Finally, the simulation results and comparison analysis based on the New England 39-bus test system validates the implementation effects of the proposed controlled islanding strategy.
CHANGES IN METABOLIC SYNDROME PHENOTYPES IN ELDERLY OF ASIAN INDIAN ORIGIN: THE SANTINIKETAN LONGITUDINAL STUDY ON AGEING

age there no studies on changes in MS phenotypes the Indian population. the present longitudinal study aimed to examine the longitudinal (yearly ABSTRACT Objective : Virtually no studies have been undertaken to investigate the changes (longitudinal) in metabolic syndrome (MS) phenotypes in elderly people of Asian Indian origin. The present study was aimed to examine the longitudinal changes (yearly change) in MS phenotypes in elderly people of Asian Indian origin. Methods : A total of 254 participants aged 55 years and above took part in this longitudinal study. Anthropometric measures were collected using standard techniques. Measures and obesity and body composition were subsequently calculated. Metabolic profiles and blood pressure were also measured. All anthropometric, metabolic and blood pressure measures were twice measured in a gape of one exact year. Results : The ANOVA revealed significant phase differences in both sexes for BMI, TER, and LDL whereas, phase differences for TC, TG, HDL, and VLDL. It was further observed that there existed significant phase differences for WC (only for male), TG and HDL (only for male) status. Conclusion : This thing vindicated the fact that people of Asian Indian origin maintain a considerable level of central or abdominal obesity along with increased level of metabolic profiles and haemodynamic factors (i.e. blood pressure) notwithstanding of progressive age.
Revision of some morphometric characteristics and building the standard haematological reference value in Rita rita from Pakistan

This study was aimed to measure some morphometric and haematological characters of Rita rita captured in the L.B. D canal from river Ravi. The morphometric measurement was carried through measuring tape and scale rod and weight was taken with the help of digital balance. The haematological analysis was carried out through the Neubauer haemocytometer. The weight of fish was 86.55±52.23 g, length with tail 18.72±3.66 cm, total length without tail 15.40±2.79 cm, length of tail/caudal fin 3.34±1.05 cm, and the girth/width 10.88±2.23cm. The distance between eyes was 2.08±0.41cm, between nostrils 1.23±0.30 cm. Length of mandibles was 2.14±0.69 cm, maxilla 2.31±0.74 cm, width of head 4.25±1.65 cm, diameter of eye 0.25±0.10 cm. Length of dorsal fin was 4.57±1.51 cm, width 2.71±0.83 cm, length of adipose fin 2.17±0.50 cm, width fin 0.72±0.2cm, length of anal fin 2.34±0.54 cm, width 1.84±0.57 cm, length of pectoral fin 3.63±0.90 cm, width 2.15±0.53cm, length of pelvic fin 2.16±0.87cm and width 1.40±0.42cm. The number of rays of the dorsal fin was 6+1±0.30, anal fin 9±1.36, pectoral fin 6+1±0.98, pelvic fin 7±1.02, and tail /caudal fin 17±1.31. The relationship between length and weight showed that the relationship was non-linear and growth was allometric. Regarding the haematological analysis, RBCs were 4.92±0.45 x10 6 /mm 3 , haemoglobin 8.6±2.11g/dL, WBCs 2.32±0.30, platelets 53.4±11.07, neutrophils 7.4±3.2%, Lymphocytes 89.2±4.26%, Monocytes 2±1.55% and Eosinophils 1.2±0.4%. The alkaline phosphatase (ALP) and acid phosphatase (ACP) was above than reference value which showed that river pollution has started damaging the body organs of fish.
Planck intermediate results. LIII. Detection of velocity dispersion from the kinetic Sunyaev-Zeldovich eﬀect

Using the Planck full-mission data, we present a detection of the temperature (and therefore velocity) dispersion due to the kinetic Sunyaev-Zeldovich (kSZ) eﬀect from clusters of galaxies. To suppress the primary CMB and instrumental noise we derive a matched ﬁlter and then convolve it with the Planck foreground-cleaned “ 2D-ILC ” maps. By using the Meta Catalogue of X- ray detected Clusters of galaxies (MCXC), we determine the normalized rms dispersion of the temperature ﬂuctuations at the positions of clusters, ﬁnding that this shows excess variance compared with the noise expectation. We then build an unbiased statistical estimator of the signal, determining that the normalized mean temperature dispersion of 1526 clusters is h (∆ T/T ) 2 i = (1 . 64 ± 0 . 48) × 10 − 11 . However, comparison with analytic calculations and simulations suggest that around 0 . 7 σ of this result is due to cluster lensing rather than the kSZ eﬀect. By correcting this, the temperature dispersion is measured to be h (∆ T/T ) 2 i = (1 . 35 ± 0 . 48) × 10 − 11 , which gives a detection at the 2 . 8 σ level. We further convert uniform-weight temperature dispersion into a measurement of the line-of-sight velocity dispersion, by using estimates of the optical depth of each cluster (which introduces additional uncertainty into the estimate). We ﬁnd that the velocity dispersion is h v 2 i = (123 000 ± 71 000) ( kms − 1 ) 2 , which is consistent with ﬁndings from other large-scale structure studies, and provides direct evidence of statistical homogeneity on scales of 600 h − 1 Mpc. Our study shows the promise of using cross-correlations of the kSZ eﬀect with large-scale structure in order to constrain the growth of structure.
Streaming Networks Sampling using top-K Method

: The combination of top-K network representation of the data stream with community detection is a novel approach to streaming networks sampling. Keeping an always up-to-date sample of the full network, the advantage of this method, compared to previous, is that it preserves larger communities and original network distribution. Empirically, it will also be shown that these techniques, in conjunction with community detection, provide effective ways to perform sampling and analysis of large scale streaming networks with power law distributions.
Verifying driver performance for heavy haulage fatigue management

Working performance of drivers is an important concern of commercial logistics firms as it directly relates to operational efficiency targets. However, in heavy vehicle activity, the enforcement of fatigue management rules by the Australian government can potentially influence this efficiency as the regulation scheme controls maximum work time and minimum rest time of drivers. Therefore, evaluating a driver’s performance in the context of fatigue compliance is an essential need that aims to assist transport operators increase their operational efficiencies. This research proposes a method in assessing how well a driver performs their job by using anomaly detection principles from Intrusion Detection Systems in Network Security. This approach utilises output data of the Logistics Fatigue Manager Application and compliance outcomes of the Fatigue Compliance Verification System to measure driver performance. In addition to performance concerns, the system also monitors safety levels based on fatigue conditions of drivers to ensure that the positive evaluation outcomes can become applied standards for the whole fleet in practice. The results highlight the opportunity to monitor driver fatigue levels for verifying fatigue risk within existing fatigue compliance requirements.
Impacts of dietary forage and crude protein levels on the shedding of Escherichia coli O157:H7 and Listeria in dairy cattle feces

The shedding of Escherichia coli O157:H7 and Listeria monocytogenes in the feces of ruminants and the consequential risk to the public and environmental health is well reported. However, the in ﬂ uence of dietary manipulation on the shedding of fecal bacteria is not well understood. This study was conducted to improve understanding of the relationship between dietary feed composition and shedding of E. coli O157:H7 and Listeria spp. in dairy feces. Twelve cows were randomly assigned to four treatment diets of two dietary forage levels: low forage (37.4% dry matter, DM) vs. high forage (53.3% of DM) and two dietary crude protein (CP) levels: low protein (15.2% of DM) vs. high protein (18.5% of DM) in a 4×4 replicated Latin square design with four periods each including a 14 d adaptation and 3 d sample collection periods. Generic E. coli was detected in some of the feed ingredients, such as cotton seed, alfalfa hay, almond, and CaCO 3 , while Listeria was detected in the alfalfa hay and mineral mix. A signi ﬁ cant interaction e ﬀ ect was observed between dietary forage and CP on the presence of fecal E. coli O157:H7 ( P =0.01) but not with Listeria . On average, the greatest E. coli O157:H7 level (6.6 log 10 CFU/g of feces) was observed from the high forage and high protein diet and the lowest level was 6.1 log 10 CFU/g from the low forage and high protein diet. The average Listeria shedding rate was within the range of 1.7 – 2.3 log 10 CFU/g among the dietary forage and CP treatments. For the CP treatments, signi ﬁ cantly low levels of Listeria were observed from cows fed the high protein (0.9 − 1.6 log 10 CFU/g) compared to the low protein (1.3 – 2.1 log 10 CFU/g) diet. Considering temporal ﬂ uctuations, no signi ﬁ cant diurnal pattern was observed for either E.coli O157:H7 or Listeria . In addition, no time of sampling over day by dietary forage or CP content interaction on fecal E.coli O157:H7 or Listeria level was observed. This study showed that diets can in ﬂ uence the shedding of potentially pathogenic bacteria in dairy cow excreta.
of with a review of selected aspects.

It is well known that phenylhydrazine induces hemolytic anemia. This is thought to result from the reaction of phenylhydrazine with hemoglobin. The accompanying oxidation of phenylhydrazine leads to the formation of a number of products, including benzene, nitrogen, hydrogen peroxide, superoxide anion and the phenyl radical. The products formed depend critically on the conditions of the experiment, es-pecially the amount of oxygen present. It is now known that oxyhemoglobin and myoglobin react with phenylhydrazine to yield a derivative of hemoglobin containing N-phenylprotoporphyrin in which the heme group is modified. The recent identification of cr-phenyliron(III) porphyrins in phenylhydrazine- modified metmyoglobin has aided elucidation of the mechanism of hemoglobin modification. Mechanistic schemes are proposed to account for product formation.
Variable Gene Repertoires Rotavirus Share Common Immunodominant Infant and Adult Human B Cell Responses to

Ab repertoires exhibit marked restrictions during fetal life characterized by biases of variable gene usage and lack of junctional diversity. We tested the hypothesis that Ab repertoire restriction contributes to the observed poor quality of speciﬁc Ab responses made by infants to viral infections. We analyzed the molecular determinants of B cell responses in humans to two Ags of rotavirus (RV), a common and clinically important infection of human infants. We sequenced Ab H and L chain V region genes (V H and V L ) of clones expanded from single B cells responding to RV virus protein 6 or virus protein 7. We found that adults exhibited a distinct bias in use of gene segments in the V H 1 and V H 4 families, for example, V H 1–46, V H 4–31, and V H 4–61. This gene segment bias differed markedly from the V H 3 dominant bias seen in randomly selected adult B cells. Recombinant Abs incorpo-rating any of those three immunodominant V H segments bound to RV-infected cells and also to puriﬁed RV particles. The RV-speciﬁc B cell repertoires of infants aged 2–11 mo and those of adults were highly related when compared by V H , D, J H , V L , and J L segment selection, extent of junctional diversity, and mean H chain complementarity determining region 3 length. These data suggest that residual fetal bias of the B cell repertoire is not a limiting determinant of the quality of Ab responses to viruses of infants beyond the neonatal period. The Journal of Immunology, 2003, 171: 4680–4688. was 11 conﬁrmed clones ampliﬁed of 2359 B cells sorted (0.5%) and for RV VP6-speciﬁc V H segments 3 conﬁrmed clones ampliﬁed from 2359 sorted B cells (0.1%). The efﬁciency data for RV VP7- or VP6-speciﬁc V L segments were 11 of 2359 sorted B cells (0.5%) and 2 of 2359 sorted B cells (0.1%), respectively.