Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychometric properties of the Cognitive Behaviour Therapy Scale for Children and Young People (CBTS-CYP) in a Turkish sample

Abstract Background: Cognitive behavioural therapy (CBT) training is highly demanded by clinicians; however, a standardized competence assessment for professionals working with children and young people (CYP) can be problematic. Psychometric tools used for this purpose are typically adult oriented measures. Aim: The present study provides psychometric properties of the Cognitive Behaviour Therapy Scale for Children and Young People (CBTS-CYP) derived from a comparative analysis with the Cognitive Therapy Scale (CTS). Method: The CBTS-CYP was used alongside CTS in a CBT supervision training course, consisting of a cohort of 51 therapists. A total of 36 audio/video recorded full CBT sessions were assessed for the purpose of determining CBT competence and adherence to the theory and model. The training involved a total of 80 hours of supervision in 10 meetings via an online videoconferencing platform between July 2020 and February 2021. Results: Face validity and inter-rater reliability of CBTS-CYP were high, with the intraclass correlation values being good (0.60–0.74) or excellent (0.74 and above); the correlations of each CBTS-CYP and CTS items were significant; internal consistency of the scale showed that Cronbach alpha values for total-scale and its two subdimensions were above . 93. For a cut-off score of 55 out of 90, sensitivity reached 90.73% and specificity 90.73%. A score of 2 points or above from any single item could be considered as the second minimum criterion for competence. Conclusions: CBTS-CYP offers a valid and reliable scale to evaluate the competence and adherence quality of CBT sessions with children and adolescents.
Differences in Meaning of Occupations Between Children With and Without Neurodevelopmental Disorders

Engaging children in meaningful occupations is a means of improving their participation. The objective of this study is to assess differences in dimensions of meaning of occupations—challenge, value, felt time, and autonomy—between children with and without neurodevelopmental disorders and their associations with the participation of each group. Thirty children with neurodevelopmental disorders (autism spectrum disorder [ASD]/attention deficit hyperactive disorder [ADHD]) and 30 typically developing children (M age = 9.37 ± 1.41 years) reported regarding dimensions of meaning of occupations. Their parents reported regarding children’s participation. Children with neurodevelopmental disorders attach different meanings to their everyday activities than their typically developing peers, with a large effect size ( η p 2 = .07–.12). For children with neurodevelopmental disorders, the value and autonomy dimensions of meaning were correlated with participation. The findings expand knowledge of occupational meaning and participation among children. To optimize the participation of children, occupational therapists should facilitate autonomy and engage children in activities that they value.
Period poverty and mental health in times of Covid-19 in France

Abstract We investigate the relationship between period poverty and anxiety and depression in women aged from 18 to 50 years in the context of the first French Covid-19 lockdown. 890 participants completed an online survey. Anxiety was assessed with the General Anxiety Disorder scale, depression with the Major Depression Inventory. 9.6% of participants experienced difficulties accessing period protection during the first lockdown. Among the women experiencing period poverty, 49.4% showed depressive symptoms compared to 28.6% of the women who had not experienced menstrual poverty, 40% showed anxious symptoms (vs 24.1%). The relationships between period poverty, depression and are significant even in adjusted models controlled by sociodemographics variables (depression: AOR = 2.191 [1.372 − 3.499]; anxiety: AOR = 1.793, [1.110 − 2.897]). As clinicians, psychologists or social workers, it seems interesting to go beyond the first symptoms of depression and anxiety and question the patients’ access to menstrual health products.
Sodium propionate improves rheumatoid arthritis by inhibiting survivin mediated proliferation of fibroblast like synoviocytes by promoting miR-140-5p

Abstract Background Increased proliferation and impaired death of fibroblast-like synovial cells play an important role in the development of rheumatoid arthritis (RA). Survivin plays an important role in the prodromal stage and prognosis of RA and has been introduced as a biomarker of joint injury in RA patients. The purpose of this study was to explore whether propionate alleviates RA through miR-140-5p/survivin pathway. Methods The synovial tissues of RA patients were collected to detect the expression levels of miR-140-5p and survivin; normal human fibroblast-like synovial cells (HLSs) and RA fibroblast-like synovial cells (RA-FLSs) were cultured and treated with 10 mM of sodium propionate (SP), then the expressions of miR-140-5p and survivin, cell viability and apoptosis were detected; collagen induced arthritis (CIA) rat model was constructed and treated with SP, then the tissue inflammation level and the expression levels of miR-140-5p and Survivin were detected. Results The expression of miR-140-5p decreased in synovial tissues of RA patients and RA-FLSs cells, while the expression of survivin increased significantly in RA patients. SP promoted miR-140-5p expression and apoptosis in RA-FLSs cells and inhibited survivin expression and cell viability of RA-FLSs cells. In addition, miR-140-5p plays a protective role by targeting survivin. Importantly, in the CIA rat model, SP reduced joint inflammatory response, and the miR-140-5p inhibitor weakened the protective effect of SP. Conclusion SP can alleviate RA by promoting the expression of miR-140-5p and inhibiting the excessive proliferation and death impairment of RA-FLSs cells induced by survivin.
Early versus Late Tracheostomy Promotes Weaning in Intensive Care Unit Patients

Background and aim of the study: The time interval between the patients’ intubation and the performance of a tracheostomy has been considered as critical for the disease prognosis and outcome. The aim of the present study was to compare and contrast the outcomes of early vs late tracheostomy with regard to intensive care unit (ICU) patients’ weaning from respiratory support. Methods: This retrospective observational study, involved patients who were hospitalized in two general and one Covid-19 ICUs of two tertiary hospitals in Athens and were subjected to tracheostomy. Data were collected from the patients’ medical records in order to estimate the duration of patient weaning and the number of days from the patients’ intubation until the time of tracheostomy. In the present study the term early tracheostomy denotes tracheostomy performed within 14 days from patient intubation and late tracheostomy defines the tracheostomy carried out after 14 days. For Covid-19 patients, guidelines suggested that tracheostomies should be performed 21 days following intubation, due to the high risk of virus transmission. Results: One hundred and thirty-one patients who underwent tracheostomy participated in the study. Most tracheostomies were performed using the percutaneous technique. The group of patients tracheostomized within 14 days after their admission in ICU weaned faster from respiratory support compared to ones who were tracheostomized after 14 days. Conclusions: The most common distinction between early and late tracheostomy is 14 days, with early tracheostomy being more beneficial in terms of patients’ outcomes, and specifically ICU patients’ weaning. (www.actabiomedica.it)
Computational assessment of Withania somnifera phytomolecules as putative inhibitors of Mycobacterium tuberculosis CTP synthase PyrG

Abstract Genome evolution of Mycobacterium tuberculosis (Mtb) produces new strains resistant to various pre-existing anti-tubercular drugs. Hence, there is an urgent need to explore potent compounds with the most negligible side effects and effective Mtb inhibition. Mtb PyrG (CTP synthase) is a crucial enzyme for the conversion of the uridine triphosphate (UTP) into cytidine triphosphate (CTP) and is essential for the growth of Mtb. Thus, in this study, phytochemicals of Withania somnifera (W. somnifera) were screened to find the potential inhibitors against Mtb PyrG. Molecular docking resulted in the identification of quercetin 3-rutinoside-7-glucoside, rutin, chlorogenic acid and isochlorogenic acid C with a substantial docking score (from −12.6 to −10.8 kcal/mol) contributed by significant intermolecular interactions. Furthermore, 100 ns molecular dynamics simulation, ADME analysis and free binding energy calculations support the stability of docked complexes and drug-likeness for selected compounds, respectively. Collectively, these findings suggest that phytochemicals present in W. somnifera can be considered for further evaluation against Mtb in a series of in vitro and in vivo models. Communicated by Ramaswamy H. Sarma
A printability study of multichannel nerve guidance conduits using projection-based three-dimensional printing

Multichannel nerve guidance conduits (NGCs) replicating the native architecture of peripheral nerves have emerged as promising alternatives to autologous nerve grafts. However, manufacturing multichannel NGCs is challenging in terms of desired structural stability and resolution. In this study, we systematically investigated the effects of photopolymer properties, inner diameter dimensions, printing parameters, and different conditions on multichannel NGCs printability using projection-based three-dimensional printing. Low viscosity and rapid photocuring properties were essential requirements. A standard model was generated to evaluate multichannel NGC printed quality. The results showed that printing deviations decreased with increased mechanical strength and inner diameter. Subsequently, gelatin methacrylate (GelMA) NGCs was selected as a representative. It was found that printing conditions, including printing temperature, peeling, and shrinkage affected final NGC accuracy and quality. PC-12 cells cultured with the GelMA NGCs displayed non-toxic and promoted cell migration. Our research provides an effective, time-saving, and high-resolution technology for manufacturing multichannel NGCs with high fidelity, which may be used as reference templates for biomedical applications.
Modeling, Simulation, and Implementation of a Solar Thermoelectric Energy Harvesting System

New alternatives and inventive renewable energy techniques which encompass both generation and power management solutions are fundamental for meeting remote residential energy supply and demand today, especially if the grid is quasi-inexistent. Solar thermoelectric generators mounted on a dual-axis sun tracker can be a cost-effective alternative to photovoltaics for remote residential household power generation. A complete solar thermoelectric energy harvesting system is presented in this paper for energy delivery to remote residential areas in developing regions. To this end, the entire system was built, modeled, and then validated with the LTspice simulator software via the thermal-to-electrical analogy schemes. Valuable data in conjunction with a novel LTspice circuit were obtained, showing the achievability of analyzing transient heat transfer with the SPICE simulator; however a few of the problems to be solved remain at the practical level. Despite the unusual operation of the thermoelectric modules with the solar radiation, the simulation and measurements were in good agreement, thus validating the new modeling strategy.
Learning curve for robot-assisted laparoscopic radical prostatectomy in a large prospective multicentre study

Abstract Objective Differences in outcome after radical prostatectomy for prostate cancer can partly be explained by intersurgeon differences, where degree of experience is one important aspect. This study aims to define the learning curve of robot-assisted laparoscopic prostatectomy (RALP) regarding oncological and functional outcomes. Materials and methods Out of 4003 enrolled patients in the LAPPRO trial, 3583 met the inclusion criteria, of whom 885 were operated on by an open technique. In total, 2672 patients with clinically localized prostate cancer from seven Swedish centres were operated on by RALP and followed for 8 years (LAPPRO trial). Oncological outcomes were pathology-reported surgical margins and biochemical recurrence at 8 years. Functional outcomes included patient-reported urinary incontinence and erectile dysfunction at 3, 12 and 24 months. Experience was surgeon-reported experience before and during the study. The relationship between surgeon experience and functional outcomes and surgical margin status was analysed by mixed-effects logistic regression. Biochemical recurrence was analysed by Cox regression, with robust standard errors. Results The learning curve for positive surgical margins was relatively flat, with rates of 21% for surgeons who had performed 0–74 cases and 24% for surgeons with > 300 cases. Biochemical recurrence at 4 years was 11% (0–74 cases) and 13% (> 300 cases). Incontinence was stable over the learning curve, but erectile function improved at 2 years, from 38% (0–74 cases) to 53% (> 300 cases). Conclusions Analysis of the learning curve for surgeons performing RALP showed that erectile function improved with increasing number of procedures, which was not the case for oncological outcomes.
Self-advocacy with retailers by people with complex communication needs

Abstract Purpose The researchers aimed to discover what might prevent people with complex communication needs (CCNs) from making complaints if they experienced social exclusion in the retail environment. Method Qualitative research methods were used to gather data from two groups of participants: adults with CCN and retail customer service staff. Seven adults who used speech-generating devices (SGDs) and who shopped independently were interviewed about their perceptions of retail customer service communication. Nine retail customer service staff were interviewed about their communication with customers with disability. Analysis using grounded theory provided insights into experiences of people with CCN. Result All participants with CCN had experienced being ignored, patronised and excluded when shopping but faced barriers that prevented them from complaining. Those who did complain exhibited strong self-esteem. Conclusion Participants with CCN experienced social exclusion because customer complaint mechanisms were inaccessible. Retailers and government agencies monitoring inclusion, as well as speech-language pathologists and disability advocates, place insufficient emphasis on retail communication as a vehicle for social inclusion. The researchers recommend strategies to strengthen self-advocacy by people with CCN and systemic changes to improve accessibility of complaints procedures in the retail sector.
An adaptive control methodology for the injection molding process. Part 2 : Experimental application

Variations in the injection molding process can be attributed to a wide variety of possible causes, including process temperature variations. An adaptive process control system has been developed that is designed to compensate for melt temperature variations that can occur from cycle to cycle. Using, this strategy, changes in melt temperature are detected by monitoring changes in the injection mold filling speed and pressure that are associated with the melt tempearature induced viscosity changes. The pressure compensation phase of the molding process is then modified to compensate for the melt temperature change in an effort to achieve dimensional consistency. In a preceeding paper, we described the methodology used to generate material specific activation energy and pvT data. This continuation of the study addresses the experimental implementation of an adaptive process control methodology using such data.
Encrypted Key Transport for Secure RTP

SRTP Encrypted Key Transport (EKT) is an extension to SRTP that provides for the secure transport of SRTP master keys, Rollover Counters, and other information, within SRTCP. This facility enables SRTP to work for decentralized conferences with minimal control, and to handle situations caused by SIP forking and early media.
Real-Time Strategies for the Deployment of Wireless Repeaters in Uncharacterized Environments

Modern society relies heavily on communication networks that in turn rely on both wired and wireless infrastructure. This work pertains to scenarios where a group of people or robots need to communicate in an environment where there is no preexisting communications infrastructure. These include sites of emergencies and disasters (e.g., inside burning buildings, search and rescue operations) and unexplored areas on Earth and other planets. Wireless ad hoc or mesh networks offer the ability to keep such entities connected, but they falter when any single entity wishes to leave the developed coverage area. Utilizing mobile repeater nodes can help, but is costly and complicated. By eliminating the need for repeater nodes to traverse the environment, their size and cost can be vastly reduced. This work explores the use of static “breadcrumb” repeater nodes to increase the reach of such a network. Determining when and where to place a static repeater node can be difficult in an environment where radio propagation characteristics are unknown. In this work, several algorithms for node placement are compared under the constraint that placement of a static repeater node should not dictate the entity’s movement. The algorithms investigated range from calculating rolling averages to modeling channel parameters on-the-fly. The placement algorithms were configured to run in real-time on TP-Link MR-3040 portable WiFi routers and the approach is demonstrated in an outdoor uncharacterized environment.
THE ROLE OF RESEARCH DESIGN IN A PURPOSE DRIVEN ENQUIRY

This paper examines the role of research design in a purpose driven enquiry. The paper bridge the gap in knowledge about the nature, importance, characteristics and classification of the research design. A survey of literature was used to identify areas of convergence and divergence of views of researchers in the same thematic areas. A qualitative research design was employed in this study. The study revealed that a good research design helps prevent frustration by provides the glue that holds the research project together through a structure plan that show how all of the major parts of the research project the samples or groups, measures, treatments or programs, and methods of assignment work together to try to address the central research questions.
Environmental Assessment of Solid Waste Management in Nigeria: A case study of Ikere Ekiti, Ekiti state

Following apparent increase in population and with a corresponding increase in solid waste generation in Ikere Ekiti, Ekiti State of Nigeria, this study was initiated to assess the level of environmental pollution and potential impact of wastes. Health risk assessment was determined by a survey of existing facilities for solid waste management. Microbiological and physicochemical analyses of decomposing waste, soil, and well water were carried out using standard procedures. Prevalent bacteria besides fungi isolated from solid waste, soil, and well water were Staphylococcus 36(25.85%), Escherichia 49 (19.61%), Pseudomonas 40 (34.11%) and each of Shigella/Salmonella 32 (21.82%), respectively. Solid waste followed by soil, had the highest count at 5% level of probability. These findings, coupled with the high aerial bacterial counts, indicate a high risk of microbial infection from the waste dump. There is also a high risk of diseases and potential destruction of biodiversity from toxic chemicals from the waste. All the physicochemical attributes determined were within the consent limits except the heavy metal levels in leachate. In view of the economy and high technology involved, it is recommended that both governments and private sectors should review the present waste management practice in relation to traditional methods.
Model simplification method for PBGA assembly simulation under random vibration

In the plastic ball grid array package (PBGA) assembly, there are many solder balls and copper pads. The whole packaging varies a lot in size. This multi-scale structure brings difficulties in building the finite element model. The paper refers a method to avoid difficulties by replacing the unconcern copper pad/solder mask layer with a homogenous material layer. The finite element method (FEM) is used to prove simplification model's accuracy.
Incorporating African American Veterans' Success Stories for Incorporating African American Veterans' Success Stories for Hypertension Management: Developing a Behavioral Support Hypertension Management: Developing a Behavioral Support Texting Protocol Texting Protocol Let us know how access to this

Background: Peer narratives engage listeners through personally relevant content and have been shown to promote lifestyle change and effective self-management among patients with hypertension. Incorporating key quotations from these stories into follow-up text messages is a novel way to continue the conversation , providing reinforcement of health behaviors in the patients’ daily lives. Objective: strategies to self-management. to describe our for developing a text-messaging protocol intended for use after that incorporate the of these We used a video-recorded into We into texting We an iterative of story transcripts to identify vernacular features and key self-management concepts emphasized by storyteller. We worked our narrative text message development in substantive ways, as we sought to craft culturally sensitive content for texts. by input on timing and integration, supplementary educational and 2-way interactive assessment text were Within the Veterans Affairs texting system Annie , we programmed five 6-month text-messaging protocols that included cycles of 3 text message types: narrative messages, nonnarrative educational messages, and 2-way interactive messages assessing self-efficacy and behavior related to hypertension self-management. Each protocol corresponds to a single Veteran storyteller, allowing Veterans to choose the story that most resonates with their own life experiences. Conclusions: We crafted a culturally sensitive text-messaging protocol using narrative content referenced in Veteran stories to support effective hypertension self-management. Integrating narrative content into a mobile health texting intervention provides a low-cost way to support longitudinal behavior change. A randomized trial is underway to test its impact on the lifestyle changes and blood pressure of African American Veterans.