Miracle-dz/UniFAR-FTUs huggingface dataset:
Low concentration of caffeine inhibits cell viability , migration and invasion , and induces cell apoptosis of B 16 F 10 melanoma cells

We aimed to explore the effects of low concentration of 1, 3, 7-trimethylxanthine (caffeine) on melanoma cells, as well as the underlying mechanism. In this work, B16F10 murine melanoma cells were pre-treated with different concentrations (0, 50, 100, 200, 400 or 600 μM) of caffeine for 24 h, 48 h, or 72 h. The cell viability was determined by the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. The migration and invasion assay were assessed by Transwell system. The cell apoptosis were analyzed by Annexin V-Cy5 and propidium iodide (PI) staining. The protein levels of bone morphogenetic protein (BMP) 2, BMP4, BMP7, B-cell lymphoma (Bcl-2), and Bax were measured by Western blot. The results showed that caffeine (400 or 600 μM) pretreatment significantly reduced the cell viability at 48 h and 72 h (P < 0.05 or P < 0.01) but not at 24 h. The number of migrated and invaded cells was significantly decreased by caffeine (200, 400 or 600 μM) (P < 0.05 or P < 0.01). Moreover, the percentages of apoptotic cells were statistically increased by 200, 400 or 600 μM of caffeine (P < 0.05 or P < 0.01). We also observed caffeine (200, 400 or 600 μM) significantly down-regulated the levels of BMP2 and BMP4 but not BMP7, and statistically down-regulated the ratio of Bcl-2 to Bax (P < 0.05 or P < 0.01). To conclude, low concentration of caffeine inhibits cell viability, migration and invasion, and induces cell apoptosis of B16F10 melanoma cells.
Route-Based Markov Decision Processes for Dynamic Vehicle Routing Problems

We propose a new modeling framework for dynamic routing problems (DRPs). DRPs are problems in which a set of geographically dispersed customers is visited by one or more travelers or vehicles, information changes stochastically over the problem horizon, and there exist opportunities to make decisions in response to new information. Acknowledging the disconnect between model and method in DRP research, our framework extends the conventional Markov decision process (MDP) model for dynamic and stochastic optimization problems to more closely align with route-based solution methodologies predominate in the DRP literature. We construct route-based MDPs by redefining the conventional MDP action space to operate on sets of planned routes. The modification leads to a generalization of the conventional MDP state (and post-decision state) to include route plans and to a definition of the current-period reward or cost to be the marginal change in value associated with a route plan update.In addition to joining the model with both application and method, route-based MDPs are positioned to facilitate more scientific rigor in DRP studies. We anticipate route-based MDPs will provide researchers with a common language, allow for better inquiry, and improve classification and description of solution methods. Under an easily satisfiable condition, we show route-based MDPs are equivalent to the conventional MDP model, thus providing a formal means to model the evolution of routes in a sequential decision-making environment. Via an example from the literature, we illustrate the value of connecting model and solution methodology.
Bonus Cuts or Firing-The Role of Flexible Wage Components in Firm Competition and Protecting Jobs

A large share of workers receives bonus payments besides their base wage. The bene ts of exible wage components in remuneration are twofold: they can incentivize workers and make it easier to adjust wages downward in response to negative shocks. Using data on bonus payments of Hungarian workers from linked employer-employee data, I disentangle the these two factors to assess their respective importance . First, I show that bonus payments exibly adjust to revenue shocks of rms. However, this exibility does not smooth employment . In addition to that, bonus paying rms are nancially more stable, larger and more productive and have less volatile revenue than rms not paying bonuses. These facts can be explained by a wage posting model with incentive contracting, but they are hard to reconcile with models emphasizing the role of bonus payments alleviating wage rigidity. These results indicate that wage exibility regulations are unlikely to attenuate employment responses to negative shocks.
Research on the Forecasting Model of Logistics Volume Based on the Theory of Large Transportation and Logistics : Taking Qingdao City as an Example

In order to realize the effective forecast of logistics volume in Qingdao, this paper studied the forecasting method based on the combination of qualitative and quantitative analysis of the large transportation logistics theory. After analyzed the particularity of Qingdao logistics, this study selected and established a prediction model based on the multiple linear regression. Moreover, this study used the MATLAB software to calculate the equation of regression model according to the years of logisticsrelated data of Qingdao. Finally, it validated the feasibility of the forecasting model by system simulation in logistics.
Still Learning After All These Years: Dynamic Information Acquisition in Banking∗

This paper explores the implications of asymmetric information and learning in banking. We hypothesize that banks acquire private information about borrower quality when establishing firm-bank relationships. We develop a general methodology to test this hypothesis, and apply this using a dataset for 7,707 syndicated loans made between 1987 and 2003. Our tests require the construction of a variable from the future that is correlated with firm quality and is unobservable by the bank, so it cannot be used directly to price loans. We find that the loading on this proxy in the bank’s pricing equation increases with relationship time, as we would expect if banks were privately learning about firm fundamentals through their relationships with firms. The results are robust to controlling for public, i.e. market-wide, learning. Our findings are the strongest evidence to date that banks acquire valuable private information about borrowers via lending relationships. We find that private bank learning about firm quality particularly benefits higher-quality borrowers, who receive lower interest rates on subsequent loans.
On Fundamentals and Applications of Superhydrophobicity in Papermaking and Packaging

Fundamental material science investigations of superhydrophobicity in recent years has evolved toward industrial applications and recently to papermaking and packaging. The present study concerns both fundamental and applied aspects of superhydrophobicity. An industrially viable process for a one-step waterborne superhydrophobic coating was developed. It is shown that different measures of the degree of superhydrophobicity are needed depending on the ﬁnal application whether this may be self-cleaning or stain repellent action. Fundamental aspects of superhydrophobicity were investigated using silica wafers roughened by a particulate formulation containing nanosize silica particles, which were ﬁxed to the substrate by calcination. After hydrophobization by silylation, the forces between a colloidal superhydrophobized silica probe, made according to a similar procedure, and these surfaces were measured by Atomic Force Colloidal Probe Microscopy. The results show an extremely long range interaction force and a large inﬂuence of surfactant and surfactant concentration. The results would prove useful in designing robust superhydrophobic application in the papermaking and packaging industry and also imply that coating and printing technique could be used for controlled deposition of superhydrophobized layers or areas.
Appendix of FCAF3D

Comments on Eq. 3. The OBB heading angle θ is typically defined as an angle between x-axis and a vector towards a center of one of OBB faces. If a frontal face exists, then θ is defined unambiguously; however, this is not the case for some indoor objects. If a frontal face cannot be chosen unequivocally, there are four possible representations for a single OBB. The heading angle describes a rotation within the xy plane around z-axis w.r. t. the OBB center. Therefore, the OBB center (x, y, z), height h, and the OBB size s = w+ l are the same for all representations. Meanwhile, the ratio q = wl of the frontal and lateral OBB faces and the heading angle θ do vary. Specifically, there are four options for the heading angle: θ, θ+ π2 , θ+ π, θ+ 3π 2 . Swapping frontal and lateral faces gives two ratio options: q and 1q . Overall, there are four different tuples (q, θ) for the same OBB:
Lung cancer in Fujian Province , China ( 2009-2012 ) : a single-institute retrospective study

There are distinct regional differences among lung cancer patients in China. This retrospective study sought to determine the clinical characteristics and prognostic factors of lung cancer patients in Fujian Province, China. We conducted the study between January 2009 and August 2012 in Fujian Provincial Hospital. Patients were eligible if they had been diagnosed pathologically or cytologically with primary lung cancer. We extracted the following information from their medical records: sex, age, smoking status, stage, histological classification, nutritional status, treatment, and survival. We analyzed 831 patients, including 572 (68.8%) men and 259 (31.2%) women, with mean age of 60.22 ± 10.38 years. Among the study population, 9.1% had small cell lung cancer, 90.9% had non-small cell lung cancer, 26.5% had squamous cell carcinoma, and 52.5% had adenocarcinoma. The incidence of squamous cell carcinoma was higher in men, while that of adenocarcinoma was higher in women. Half of the patients with small cell lung cancer had advanced or extensive disease at diagnosis. Comorbid diseases were present in 28.2% of the patients, and included hypertension (72.8%), diabetes mellitus (20%), chronic obstructive pulmonary disease (3.4%), among others. For treatment, 13.5% of the total patients underwent surgery, 25.8% received chemotherapy, 22.5% received postoperative targeted therapy, and 29.4% were not treated at our hospital. Overall median survival was 24.60 ± 1.99 months. The 1-, 2-, 3-, and 4-year overall survival rate were 70.3%, 51%, 40.1%, and 32.2%, respectively. Surgery with adjuvant chemotherapy significantly improved prognosis of the small cell lung cancer patients. In conclusion, this analysis provides the most recent epidemiological information on lung cancer in Fujian, China.
IMPROVED AUDIO EDIT DETECTION USING THE PHASE ANALYSIS OF THE HARMONICS OF THE ELECTRIC NETWORK SIGNAL

The phase of the electric network signal (ENS) contains valuable information regarding a potential editing in the analyzed audio recording. When the fundamental component of the ENS is deliberately erased, an analysis of its harmonics, assuming they are present in the signal, can be performed instead. In this context we propose to detect an audio editing by tracking the phase discontinuities of the ENS harmonics (ENSH) not over the entire signal, but only over the silence segments from a speech recording. A direct consequence of our approach is the separation of the ENSH components from dominant speech components, which in turn allows a better detection and estimation of the ENSH parameters. We complete the algorithm with a simple energy based criterion for the ENSH detection, which in conjunction with a high accuracy spectral analysis method based on the instantaneous frequency attractors, leads to superior results in terms of audio editing detection rate. Compared with similar methods, the proposed algorithm is less time-consuming and provides good detection rates even for speech signals rich in low frequency content (e.g. male voices).
15 Silicon-Based Nanowire MOSFETs : From Process and Device Physics to Simulation and Modeling

Over the past few years tremendous progress has been made on the process, application, device physics and compact modeling of nanowire MOSFETs. We would like to review the above aspects of silicon-based nanowire, focusing on its crucial compact models and the circuit performance demonstration based on our group research work and understanding on nanowire MOSFET progress. Nanowire MOSFETs are recognized as one of the most promising candidates to extend Moore’s law into nanoelectronics era. Both the top-down (Singh et al., 2008) and bottom-up (Lu & Lieber, 2006) approaches are widely studied to prepare ultra small nanowire. With bottom-up method, nanowires are generally synthesized by using metal nanoclusters as catalysts via a vapor-liquid-solid process (Lu & Lieber, 2006). After growth nanowires are transferred to silicon substrate to form FET structure. With top-down technique there are various fabrication approaches, such as hard mask trimming, etching in H2 ambient and stress limited oxidation (Singh et al., 2008). 5-nm gate length device has been demonstrated (Liow et al., 2008). Nanowire MOSFETs prepared with both methods find application in logic circuits (Singh et al., 2008), memory (Singh et al., 2008) and sensors (Stern et al., 2008). Due to the quantum confinement in cross section of nanowire MOSFETs, especially of nanowires with diameter smaller than 15nm, electron mobility behaves differently from its bulk counterpart. Phonon-limited electron mobility decreases with reducing the wire size (Kotlyar et al., 2004) while total electron mobility is enhanced due to volume inversion at high transverse field (Jin et al., 2007). Although whether or not ballistic transport can occur in the silicon nanowire MOSFETs with ultrasmall channel length is disputable (Ferry et al., 2008), it deserves our attention. In the ballistic transport regime, carrier scattering in the device channel is totally suppressed. The study of ballistic transport in nanowire MOSFETs provides the upper limit to their performances. Under extreme scaling of nanowire MOSFETs, the atoms in nanowire cross section are countable. It is believed that the change in bandstructure of one dimensional nanowire influences the device performances (Neophytou et al., 2008). The above mentioned phenomenon are studied and simulated with various numerical approaches and also need to be accounted for in the advanced compact models.
The Robustness of Conditional Logit for Binary Response Panel Data Models with Serial Correlation

Abstract We examine the conditional logit estimator for binary panel data models with unobserved heterogeneity. A key assumption used to derive the conditional logit estimator is conditional serial independence (CI), which is problematic when the underlying innovations are serially correlated. A Monte Carlo experiment suggests that the conditional logit estimator is not robust to violation of the CI assumption. We find that higher persistence and smaller time dimension both increase the magnitude of the bias in slope parameter estimates. We also compare conditional logit to unconditional logit, bias corrected unconditional logit, and pooled correlated random effects logit.
Akademia Baru Induction and Microscopic Characterization of Globular Callus from Stem Explant of Labisia Pumila var .

Labisia pumila (BI.) F. Vill (Myrsinaceae) also known as Kacip Fatimah is a medicinal plant with an enormous therapeutics value and used widely for herbal industry in Malaysia. This study reports the induction of globular calli from stem explants of L. pumila var. alata. The embryogenic characteristics of the globular calli were further confirmed by morphological and histological analyses using the light microscope of sectioned material and scanning electron microscope. Globular callus was induced from stem explants that were pre-treated/un-pretreated with thidiazuron (TDZ) on Murashige and Skoog (MS) medium supplemented with 20 μM 2,4dichlorophenoxyacetic acid (2,4-D) and various amino acids (glutamine, arginine, proline and leucine) at the concentrations of 0.05, 0.1, 0.25 and 0.5 mM. After 6 weeks of incubation, explants pre-treated with TDZ induced 100% of globular callus while only friable calli were observed on unpretreated explants. Addition of amino acids at concentrations between 0.05-0.25 mM enhanced induction of globular callus. Off all, 0.25 mM leucine provided the highest callus score (5.93±0.12) which produced 31 to 40 globular callus per explant. Double staining test shows the positive reaction to aceto-carmine red (0.5%) in the globular callus indicating the existence of embryogenic nature. Analysis under SEM and histological evaluation has confirmed the embryogenic characteristics with the appearance of isodiametric clump cells and containing prominent nuclei. The globular callus is further regenerated to shoots clump, thus, it is suggested that the use of TDZ-pretreatment method with addition of 20 μM 2,4-D and 0.25mM leucine successfully induced embryogenic callus from stem explant of L. pumila var. alata. Copyright © 2015 Penerbit Akademia Baru All rights reserved.
EXPERIMENTAL STUDIES TO DETERMINE THE FLEXURAL AND CRACKING PERFORMANCE OF HYBRID STEEL-MESH AND POLYOLEFIN-FIBER REINFORCED CEMENTITIOUS COMPOSITES

In this experimental study, the flexural and cracking performance of Hybrid Steel Mesh and Polyolefin Fiber Reinforced Cementitious Composites (HSMPOFRCC) (test specimens) of slab size 700 mm × 200 mm × 25 mm are investigated under four point loading, and the results are compared with Steel Mesh Reinforced Cementitious Composites (SMRCC) (control specimens). Taguchi's Experimental Design technique was employed to optimize the number of experiments, and the standard L18 (6^1 3^1) orthogonal array was used. On conducting the flexural tests for HSMPOFRCC with several hybrid reinforcing mix combinations of steel mesh (SM 3, 4, 5 layers) and polyolefin fibers (0-2.5% of volume of specimens, with 0.5% interval), it was found that increase in fiber percentage leads to increase in first cracking strength and ultimate flexural load carrying capacity upto an optimum point. HSMPOFRCC have higher flexural strength than SMRCC. Multiple cracking behavior has been observed in the slab specimens subjected to flexural loading which demonstrate the strain hardening behavior of HSMPOFRCC. The Signal-to-Noise Ratios show higher flexural performance for slabs with hybrid reinforcing mix of 5 mesh layers and polyolefin fibers of 1, 1.5% and 2% in terms of residual flexural strength with higher level of deflection ductility. Statistical models are developed to predict the flexural strength of HSMPOFRCC.
Dynamics and Hysteresis of Colloidal Particles Dispersed in Nematic Liquid Crystals Driven by Centrifugal Force

Nematic liquid crystals with orientational order can be disturbed by electromagnetic fields, thermal gradients, and other forces. Here we demonstrated that the orientation of nematic liquid crystal molecules is influenced by the motion of colloidal particles subjected to a centrifugal force. The associated dynamics of the colloidal particles dispersed in nematic liquid crystals was also derived. The capacitance of the paricles/liquid crystal dispersion changes once its angular velocity exceeds a threshold dominated by the elastic force of the liquid crystal. Both numerical derivation and experiment showed that the elastic trapping force is associated with elastic energy and anchoring energy of particle surface. Furthermore, the hysteresis capacitance increases with increasing differential capacitance of the liquid crystals but is affected by the particle mobility. The characteristic of realigning the director by the changing rotational velocity offers numerous sensing applications, and the force mechanisms exerting on colloidal particles in nematic liquid crystals can be applied to biotechnology, microfluidic applications, or manipulation of the colloidal particles transport in anisotropic liquid.
N A ] 3 0 A pr 2 01 9 Generation of point sets by convex optimization for interpolation in reproducing kernel Hilbert spaces

We propose algorithms to take point sets for kernel-based interpolation of functions in reproducing kernel Hilbert spaces (RKHSs) by convex optimization. We consider the case of kernels with the Mercer expansion and propose an algorithm by deriving a second-order cone programming (SOCP) problem that yields n points at one sitting for a given integer n. In addition, by modifying the SOCP problem slightly, we propose another sequential algorithm that adds an arbitrary number of new points in each step. Numerical experiments show that in several cases the proposed algorithms compete with the P -greedy algorithm, which is known to provide nearly optimal points.
CENTERIS 2014-Conference on ENTERprise Information Systems / PRojMAN 2014-International Conference on Project MANagement / HCIST 2014-International Conference on Health and Social Care Information Systems and Technologies Persistent Scatterers Interferometry technique for urban subsidence monitoring

Methods of SAR interferometry data processing can detect and monitor low-amplitude motion of the earth's surface having the natural or man-made nature. The method of Persistent Scatterers Interferometry (PSI) successfully used for monitoring above mentioned processes in many cities around the world. The results of PSI technologies allow to providing geodynamic zoning of urban areas and identifying the objects exposed to linear deformation separate objects, extended linear features (e.g. subway). The paper present the results of PSI COSMO-SkyMed data processing for Astana city (capital of Kazakhstan), including the displacement distribution for individual buildings and structures, and areal coverage analysis of surface movements. Data of ENVISAT ASAR images for Almaty city received from ESA grant C1.P15390 “Spatiotemporal analysis of surface displacements in urban areas with high seismic risk by SAR interferometry data”. © 2014 The Authors. Published by Elsevier Ltd. Peer-review under responsibility of the Organizing Committees of CENTERIS/ProjMAN/HCIST 2014
The Relationship among Attitude , Anxiety and English Speaking Performance

It was aimed to designate the relationship among attitude towards English, foreign language anxiety and English speaking skills of university preparatory class students in this study. The study group consisted of 518 students who were enrolled at Ege University School of Foreign Languages Preparatory Class. “Attitudes towards English Questionnaire” and “Foreign Language Classroom Anxiety Scale (FLCAS)” were used as instruments. Students’ English speaking scores in the first term of 2014-2015 academic year were taken into account to determine their English speaking level. In the analysis of the data, SPSS 21.00 statistical package program was used. According to the findings, there was a weak and significant correlation among foreign language anxiety, attitude towards English and English speaking skills of the students. There was a negative, weak correlation between the subscales of FLCAS and English speaking skills. While the test anxiety had the biggest negative effect on English speaking skills, communication apprehension had the least adverse effect on it. There was a negative, medium correlation between attitudes towards English and foreign language anxiety of the students. It was observed that proficiency level did not have a statistically important difference on the students’ attitude towards English and foreign language anxiety.
Simple model for spherical detonation

whereu (x, t) is the unknown playing the role of, say, pressure or temperat ure, us = u (0−, t) is the solutionu immediately after the shock (located at x = 0), andf is the forcing function. The left-hand side of this equation arises from the Burgers equation by att aching the frame of reference to the shock. The forcing function on the right-hand side is taken to mimic the behavior of reaction rate in the Euler equations. In particular, strong sensitivity of f to the shock state, us, is its main feature. Furthermore, f is assumed to have a maximum at some distance away from the sho ck, xf = xf (us), which depends on the shock state. If us is large, the maximum is near the shock, while for small us the maximum is far from the shock.