Miracle-dz/UniFAR-FTUs huggingface dataset:
Characteristic of Pressure Control System with Pneumatic Vessel and Proportional Valve.

In case of charging of or discharging from a chamber with a compressible fluid, the temperature change of fluid in chamber affects pressure change as a result of convective heat transfer within the chamber wall. Therefore, in a pressure control system using a compressible fluid, the temperature change has an effect on the control characteristics of the pressure.This study analyzed how a temperature change, owing to heat transfer with the chamber wall, can affect the control characteristics of the pressure in it with a normal chamber and isothermal chamber. An isothermal chamber is a chamber that can almost realize isothermal conditions due to the larger heat transfer area and heat transfer coefficient by filling it with steel wool. As a result, this study could confirm that a slight temperature change can affect the pressure control characteristics and dynamic characteristics of pressure response, making it better by a suppression of the temperature change in a chamber.
Beyond the outcomes: generic change indicators in a video-feedback intervention with a depressed mother and her baby: a single case study

Child and dyadic psychotherapy have been scarcely investigated from the psychotherapy process research perspective. Thus, content and mechanisms related to therapeutic change have been overlooked by research. This study aimed at testing the applicability of the generic change indicators (GCI) model to identify moments of change in the parent during dyadic interventions, as well as to explore, describe and illustrate the therapeutic process through a brief mentalization-informed intervention with a depressive mother and her baby, using video-feedback as its main strategy, which has ample evidence about its effectiveness. We conducted a single case qualitative study using the GCI model. The mother’s ongoing change was determined by identifying episodes of change (EC) and moments of change (MC). Each MC was then labelled with one of the 19 GCIs. GCIs were observed from the intervention’s start. GCI’s hierarchical levels were increasing over the intervention, in association with the video-feedback situation. Our findings suggest that the GCI model is feasible to observe and understand dyadic interventions, contributing to the growing body of evidence supporting psychotherapists’ training and supervision.
Oriented Object Detection in Remote Sensing Images with Anchor-Free Oriented Region Proposal Network

Oriented object detection is a fundamental and challenging task in remote sensing image analysis that has recently drawn much attention. Currently, mainstream oriented object detectors are based on densely placed predefined anchors. However, the high number of anchors aggravates the positive and negative sample imbalance problem, which may lead to duplicate detections or missed detections. To address the problem, this paper proposes a novel anchor-free two-stage oriented object detector. We propose the Anchor-Free Oriented Region Proposal Network (AFO-RPN) to generate high-quality oriented proposals without enormous predefined anchors. To deal with rotation problems, we also propose a new representation of an oriented box based on a polar coordinate system. To solve the severe appearance ambiguity problems faced by anchor-free methods, we use a Criss-Cross Attention Feature Pyramid Network (CCA-FPN) to exploit the contextual information of each pixel and its neighbors in order to enhance the feature representation. Extensive experiments on three public remote sensing benchmarks—DOTA, DIOR-R, and HRSC2016—demonstrate that our method can achieve very promising detection performance, with a mean average precision (mAP) of 80.68%, 67.15%, and 90.45%, respectively, on the benchmarks.
Acquisition Time for Swept-Source Optical Biometry Plus Corneal Power Measurement During Cataract Evaluation

Purpose To compare the acquisition time necessary to obtain the optical biometry plus corneal power measurement using the IOLMaster 700 with central topography with that found using the standard IOLMaster 700 in combination with two corneal topographers, when acquiring biometry measurements during cataract evaluation. Methods This prospective, observational, controlled study included 96 eyes of 96 cataract patients. Acquisition times were registered for different conditions: time required for one complete measurement with IOLMaster 700 with central topography, time required for one complete measurement with standard IOLMaster 700 (without central topography), time required for one complete measurement with standard IOLMaster 700 plus time required for one complete measurement with Cassini, and time required for one complete measurement with standard IOLMaster 700 plus time required for one complete measurement with Pentacam HR. In addition, the agreement between keratometry (K), total keratometry (TK) and equivalent K reading (EKR) parameters using the three devices was performed. Results The post hoc Tukey’s test revealed that there were statistically significant differences for all pairwise comparisons (p < 0.001) except for the acquisition times of the IOLMaster with central topography and the standard IOLMaster 700 (p = 0.501). The acquisition time by the IOLMaster 700 with central topography takes approximately three less times than the use of a corneal topographer combined with a biometer. The agreement of K1, K2, TK1, TK2, EKR1 and EKR2 measurements between the three devices revealed statistically significant differences for all possible comparisons (p < 0.001) except for the comparison between the IOLMaster 700 and the Cassini for all parameters (p > 0.05). Conclusion We consider that this is an efficient procedure that improves clinical flow. We also conclude that K readings obtained with the three devices cannot be used interchangeably since there are clinically relevant differences that may affect cataract surgery outcomes.
Portable hand‐held bioprinters promote in situ tissue regeneration

Abstract Three‐dimensional bioprinting, as a novel technique of fabricating engineered tissues, is positively correlated with the ultimate goal of regenerative medicine, which is the restoration, reconstruction, and repair of lost and/or damaged tissue function. The progressive trend of this technology resulted in developing the portable hand‐held bioprinters, which could be used quite easily by surgeons and physicians. With the advent of portable hand‐held bioprinters, the obstacles and challenges of utilizing statistical bioprinters could be resolved. This review attempts to discuss the advantages and challenges of portable hand‐held bioprinters via in situ tissue regeneration. All the tissues that have been investigated by this approach were reviewed, including skin, cartilage, bone, dental, and skeletal muscle regeneration, while the tissues that could be regenerated via this approach are targeted in the authors' perspective. The design and applications of hand‐held bioprinters were discussed widely, and the marketed printers were introduced. It has been prospected that these facilities could ameliorate translating the regenerative medicine science from the bench to the bedside actively.
Study on Contamination with Some Mycotoxins in Maize and Maize-Derived Foods

Crops can be contaminated by fungi which produce mycotoxins. Many fungal strains are responsible for producing varied mycotoxins. The research carried out so far has described over 400 different mycotoxins. They have chemical and physical properties that significantly differ, and they are produced by several different existing fungi. The intake of mycotoxins through food can be achieved directly, by feeding on contaminated food, or indirectly from foods of animal origin. The mycotoxin contamination of food and food products for certain animals is a phenomenon studied worldwide, in countries in Europe but also in Asia, Africa and America. The purpose of this study is to develop an evaluation of the mycotoxins prevalent in corn and corn-derived products produced in Romania. A total of 38 maize samples and 19 corn-derivative samples were investigated for the presence of mycotoxins specific to these products, such as deoxynivalenol, zearalenone and fumonisins. Fumonisins had the highest presence and zearalenone had the lowest. The limits determined for the three mycotoxins were always in accordance with legal regulations.
Differences Between Emergency Medicine Residency Programs That Accept the Comprehensive Osteopathic Medical Licensing Examination of the United States and Those That Prefer or Only Accept the United States Medical Licensing Examination

Introduction The Comprehensive Osteopathic Medical Licensing Examination of the United States (COMLEX-USA) is a three-part series of examinations similar to the United States Medical Licensing Examination (USMLE) that osteopathic medical students must pass for medical licensure. Osteopathic students are not required to take the USMLE, but during the residency admission process, many emergency medicine (EM) residency programs will not consider osteopathic applicants who only take the COMLEX-USA. Therefore, we examined program-level characteristics between programs that accept the COMLEX-USA alone for osteopathic applicants and those that prefer the USMLE using free, publicly available online databases and residency program websites. Methods Emergency Medicine Residents’ Association (EMRA) Match was the primary database used; however, missing exam preferences were supplemented from Fellowship and Residency Electronic Interactive Database Access (FREIDA) and individual program websites. Program characteristics were compared between EM residencies that accept the COMLEX-USA and those that prefer the USMLE using the Chi-square test for categorical variables and the Mann-Whitney test for interval variables. Results Two hundred sixty of the 278 EM programs in the dataset were included in the analyses. One hundred and seven programs reported preferring the USMLE, while 151 reported accepting the COMLEX-USA alone. Programs differed by the educational environment of the primary training site (p <0.001), number of Standardized Letter(s) of Evaluation (SLOE) needed for an interview (p = 0.042), emergency department (ED) shift length (p = 0.021), former American Osteopathic Association accreditation (p <0.001), percentage of osteopathic residents (p <0.001), annual ED volume (p = 0.001), number of intern positions (p <0.001), and number of elective weeks (p = 0.028). Conclusion EM residency programs that reported accepting the COMLEX-USA alone for osteopathic applicants differed from those that prefer the USMLE. Therefore, osteopathic medical students interested in EM should consider these differences when deciding whether to take the USMLE.
Surface-Enhanced Raman Scattering from Dye Molecules in Silicon Nanowire Structures Decorated by Gold Nanoparticles

Silicon nanowires (SiNWs) prepared by metal-assisted chemical etching of crystalline silicon wafers followed by deposition of plasmonic gold (Au) nanoparticles (NPs) were explored as templates for surface-enhanced Raman scattering (SERS) from probe molecules of Methylene blue and Rhodamine B. The filling factor by pores (porosity) of SiNW arrays was found to control the SERS efficiency, and the maximal enhancement was observed for the samples with porosity of 55%, which corresponded to dense arrays of SiNWs. The obtained results are discussed in terms of the electromagnetic enhancement of SERS related to the localized surface plasmon resonances in Au-NPs on SiNW’s surfaces accompanied with light scattering in the SiNW arrays. The observed SERS effect combined with the high stability of Au-NPs, scalability, and relatively simple preparation method are promising for the application of SiNW:Au-NP hybrid nanostructures as templates in molecular sensorics.
A Bioinformatics Approach Toward Unravelling the Synaptic Molecular Crosstalk Between Alzheimer’s Disease and Diabetes

Background: Increasing evidence links impaired brain insulin signaling and insulin resistance to the development of Alzheimer’s disease (AD). Objective: This evidence prompted a search for molecular players common to AD and diabetes mellitus (DM). Methods: The work incorporated studies based on a primary care-based cohort (pcb-Cohort) and a bioinformatics analysis to identify central nodes, that are key players in AD and insulin signaling (IS) pathways. The interactome for each of these key proteins was retrieved and network maps were developed for AD and IS. Synaptic enrichment was performed to reveal synaptic common hubs. Results: Cohort analysis showed that individuals with DM exhibited a correlation with poor performance in the Mini-Mental State Examination (MMSE) cognitive test. Additionally, APOE ɛ2 allele carriers appear to potentially be relatively more protected against both DM and cognitive deficits. Ten clusters were identified in this network and 32 key synaptic proteins were common to AD and IS. Given the relevance of signaling pathways, another network was constructed focusing on protein kinases and protein phosphatases, and the top 6 kinase nodes (LRRK2, GSK3B, AKT1, EGFR, MAPK1, and FYN) were further analyzed. Conclusion: This allowed the elaboration of signaling cascades directly impacting AβPP and tau, whereby distinct signaling pathway play a major role and strengthen an AD-IS link at a molecular level.
Development of an optimization framework for landing gear design

An opportunity was identified to improve the traditional landing gear design process. Especially in the conceptual design phase, lots of man-hours are consumed by making the same calculations over and over again, for different concepts. Often, an existing gear is therefore used as initial starting point, to simplify the design process. This results in little technical progress. Additionally, integration between the different disciplines involved is sub-optimal which can lead to inconsistent results. In this thesis, an optimization framework is described that can do the preliminary design of a landing gear fully automated. It ensures that communication between disciplines is respected by adding a top-level optimizer which is in charge of changing the design variables. The realization of this framework greatly reduces the repetitive tasks in the design phase of a landing gear. This makes the design phase less limited to traditional architectures while leaving more time to evaluate non-standard solutions that may be lighter, safer and/or cheaper.
Genome-Wide Association Mapping Indicates Quantitative Genetic Control of Spot Blotch Resistance in Bread Wheat and the Favorable Effects of Some Spot Blotch Loci on Grain Yield

Spot blotch caused by the fungus Bipolaris sorokiniana poses a serious threat to bread wheat production in warm and humid wheat-growing regions of the world. Hence, the major objective of this study was to identify consistent genotyping-by-sequencing (GBS) markers associated with spot blotch resistance using genome-wide association mapping on a large set of 6,736 advanced bread wheat breeding lines from the International Maize and Wheat Improvement Center. These lines were phenotyped as seven panels at Agua Fria, Mexico between the 2013–2014 and 2019–2020 crop cycles. We identified 214 significant spot blotch associated GBS markers in all the panels, among which only 96 were significant in more than one panel, indicating a strong environmental effect on the trait and highlights the need for multiple phenotypic evaluations to identify lines with stable spot blotch resistance. The 96 consistent GBS markers were on chromosomes 1A, 1B, 1D, 2A, 3B, 4A, 5B, 5D, 6B, 7A, 7B, and 7D, including markers possibly linked to the Lr46, Sb1, Sb2 and Sb3 genes. We also report the association of the 2NS translocation from Aegilops ventricosa with spot blotch resistance in some environments. Moreover, the spot blotch favorable alleles at the 2NS translocation and two markers on chromosome 3BS (3B_2280114 and 3B_5601689) were associated with increased grain yield evaluated at several environments in Mexico and India, implying that selection for favorable alleles at these loci could enable simultaneous improvement for high grain yield and spot blotch resistance. Furthermore, a significant relationship between the percentage of favorable alleles in the lines and their spot blotch response was observed, which taken together with the multiple minor effect loci identified to be associated with spot blotch in this study, indicate quantitative genetic control of resistance. Overall, the results presented here have extended our knowledge on the genetic basis of spot blotch resistance in bread wheat and further efforts to improve genetic resistance to the disease are needed for reducing current and future losses under climate change.
Turbulent Flow Simulations of a Mixture of Perfect Gases

In this work, the finite-volume flow solver QUADFLOW is extended by applying Reynolds-averaging to the equations governing the flow of a mixture of reacting thermally-perfect gases. The Reynolds-averaged Navier-Stokes equations are closed by the Shear Stress Transport turbulence model by Menter to account for the additional terms from the averaging procedure. As an initial step, the effects of turbulence on the species source terms and the species mass diffusion are neglected in this work. To investigate high-temperature effects on the flow and to validate the extensions to QUADFLOW, the flow on a 40° compression corner is computed. In a second test case, gas injection on a scramjet intake is simulated to support the experimental design of the test case. Currently, a new test campaign is designed at the RWTH Aachen University investigating the effect of injecting fuel on the exterior intake compression ramps. The simulations presented in this work are performed analysing various design parameters, including the injection angle and wall temperatures. In addition, the effects of using a thermally-perfect gas mixture model are presented in comparison with a calorically-perfect single component gas model.
Knowledge, Attitude, and Practices Among the General Population During the Later Stage of the COVID-19 Pandemic in Malaysia: A Cross-Sectional Study

Purpose A different pattern of mental health issues was reported during the later stage of the COVID-19 pandemic; however, few studies have examined Malaysians’ knowledge, attitudes, and practices (KAP) prevalent during this time. Patients and Methods A nationwide online cross-sectional study was conducted in Malaysia from June 1, 2021 to June 14, 2021, ie, 18-months from the first reported COVID-19 case in the country. Citizens aged 18 years and above were recruited by means of the snowball sampling method. ANOVA, Pearson correlation, and linear regression tests were used. Results Of the 2168 respondents, most were young adults (62.7%), females (62.4%), tertiary educated individuals (84%), non-health care workers (85.9%), and individuals who knew someone diagnosed with COVID-19 (75.2%). The mean score for knowledge was 10.0 ± 1.52 (maximum score = 12); correct response rate for each question ranged from 54.2% to 99%. The mean score in terms of attitude was 1.3 ± 0.85 (maximum score = 2); 68.7% respondents agreed that control over COVID-19 would finally be achieved; and 62.3% believed that Malaysia could conquer COVID-19. The mean score for practices was 5.1 ± 1.10 (maximum score = 6); 81.5%, 88.1%, and 74.1% respondents avoided crowded places, confined spaces, and conversations in close physical proximity, respectively. Furthermore, 94.2% wore masks when leaving home; 89.0% practiced hand hygiene; and 83.8% adhering to COVID-19 warnings. Small but significant correlations were found between knowledge and attitude (r = 0.078, p < 0.001) as well as between knowledge and practices (r = 0.070, p = 0.001). Conclusion Malaysians exhibited sound knowledge but negative attitudes and inadequate practices pertaining to COVID-19 during the pandemic’s later stage. At this phase, unlike at the early stage, the public’s sound knowledge ensured little improvement in their attitudes and practices. Therefore, health education at the later pandemic stage should focus on promoting positive attitudes and developing better practices.
Mobile Telemedicine Screening for Diabetic Retinopathy Using Nonmydriatic Fundus Photographs in Burgundy: 11 Years of Results

We analyzed the results of mobile screening for diabetic retinopathy (DR) using retinal photographs, comparing these results between rural and periurban areas, and before and after the first national COVID-19 pandemic lockdown. The Burgundy Union Régionale des Professionnels de Santé (URPS) has organized an annual DR screening since 2004. The examination, performed by an orthoptist, consisted of taking the patient′s history, intraocular pressure measurement, and taking retinal photographs. After remote transmission, the examinations were interpreted by participating ophthalmologists at the Dijon University Hospital. In September 2016, the screening was open to periurban townships. In 11 years, 10,220 patients were screened: 1420 patients (13.9%) had DR of any type, with an average age of 68.5 (±11.3) years, and 59.2% were men. These patients had a statistically significantly higher glycated hemoglobin level (7.4% vs. 7.0%) and a longer duration of diabetes (13.8 vs. 9.3 years) than patients without DR. When comparing rural and periurban areas and periods before and after the beginning of the COVID-19 pandemic, we did not find any significant difference in the screening results. The results of this study are in line with the average findings of similar studies comparing screening strategies for DR. The early detection of DR can benefit from mobile telemedicine screening, identifying a considerable number of patients at an elevated risk, especially in rural areas where access to ophthalmological care is limited.
Pathological Internet Use, Aggression, and Cyberbullying in Children and Adolescents With Attention Deficit Hyperactivity Disorder - Editorial Comment

The purpose of the study by Yasin et al 1 was to assess the relationship between pathological internet use, aggression, and cyberbullying in children and adolescents diagnosed with Attention Deficit Hyperactivity Disorder (ADHD). It was thought to help identify factors that increase the risk of victimization of individuals with ADHD. The study found a median of 14 hours/week duration of internet use in the ADHD group, i.e. double that in the control group, a 1 SD higher internet addiction score, and a 0.61 correlation between internet use and internet addiction score, only in the ADHD group. Also, many more participants in the ADHD group reported being cyberbullied at least once (43% vs 13%), but there was no significant differ-ence in the rate of self-reported active cyberbullying. Finally, the median parent-reported aggression score was four times as high in the ADHD group than in the healthy control group, but it was not systematically related to self-reported cyberbullying or cyber victimization. The finding of higher risk of (pathological) internet use and –addiction as well as higher levels of cyber-victimization do not come as a surprise. However, the study did not find many meaningful associations indicating (modifiable) factors of risk. For example, the finding that the ADHD group was three times more often cyberbullied than the control group might be due to their substantially longer duration of internet use, but the association between cyber-victimization and internet use duration was not significant. Also, cyberbullying and –victimization were not explained by participants’ aggression. Then, was it justified to expect higher risk and clarifying associations, and why did the study not find the latter? levels of (patho-logical)