Miracle-dz/UniFAR-FTUs huggingface dataset:
Blau Syndrome and Early-Onset Sarcoidosis: A Six Case Series and Review of the Literature.

Objectives This study aims to discuss the clinical, laboratory and genetic findings, and treatment options for six patients who were diagnosed with Blau syndrome (BS)/early-onset sarcoidosis (EOS). Patients and methods The study included four patients (2 males,2 females; mean age 7 years; range 4 to 10 years) with EOS and two siblings (1 male, 1 female; mean age 10 years; range, 9 to 11 years) with BS. Age, age of initial symptoms, age of diagnosis; articular involvement, presence of uveitis, dermatitis, or fever, other organ involvement, laboratory findings, results of metabolic tests for mucopolysaccharidosis and mucolipidosis, results of genetic, pathologic, and immunologic tests, radiologic findings to evaluate skeletal dysplasia, and treatment options were collected. Results The median age at diagnosis of all patients was 6 years (range, 1 to 10 years). Five patients had camptodactyly and bilateral boggy synovitis in the wrists and ankles, one had granulomatous inflammatory changes in the liver and kidney biopsy, and one had attacks of fever and granulomatous dermatitis. None had uveitis. The detected mutations in nucleotide-binding oligomerization domain containing 2 (NOD2) were P268S (rs2066842), M513T (rs104895473), R702W (rs2066844), V955I (rs5743291), H343Y (rs199858111), and M491L (16:50745293). The treatments of patients included corticosteroids, non-steroid anti-inflammatory drugs, methotrexate, infliximab, adalimumab, anakinra, and canacinumab. Conclusion Camptodactyly and boggy synovitis are important signs of BS/EOS. Methotrexate and tumor necrosis factor blockers are more effective in patients with predominantly articular symptoms. In patients 5 and 6 and their mother, we determined a novel M491L mutation in the NOD2 gene. Currently, this work is in progress towards identifying the pathogenesis and treatment options for this disease.
Double exponential jump model (Kou)

The double exponential jump model, initiated by Steven KOU (see [1]), is an exponential Levy model, which is a compromise between reality and tractability. It gives an explanation of the two empirical phenomena which received much attention in financial markets : the asymmetric leptokurtic feature and the volatility smile. It permits to obtain analytical solutions to the prices of many derivatives : European call and put options; interest rate derivatives, such as swaptions, caps, floors, and bond options; as well as path-dependant options, such as perpetual American options, barrier, and lookback options .
Effect of Educational Intervention on Nursing Students' Performance Regarding Umbilical Cord Blood Collection for Stem Cells

Background: Umbilical cord blood is a readily available source of hematopoietic stem cells that treat a variety of malignant and non-malignant diseases in children and adult. Nurses as frontline health care professionals need to understand umbilical cord stem cells and their application in medicine. Aim of the study: To evaluate the effect of educational intervention on nursing students' performance regarding umbilical cord blood collection for stems cells. Research design: A quasi-experimental research design was used with pre/posttests. Setting: The study was conducted at the faculty of Nursing, Zagazig University. Subjects: 100 undergraduate nursing students at the fourth academic year were recruited for the study. Tools of data collection: Three tools were used. Tool (I): A student nurse self-administered questionnaire which consisted of four parts. Tool (II): Nurses student's attitudes towards cord blood collection. Tool (III): Observational checklist. Results: It was found that 90% of the students had poor knowledge before intervention which decreased to 0% and 1.8% immediately after and three months later of intervention respectively. Also, only 22% of the studied students had a positive attitude before intervention, which changed to 97% and 89% respectively at immediately after and three months later of intervention. In addition, all students(100%) had poor practices toward the collection of cord blood at pretest which changed to 0% and 3.6% at the post and follow up test with a highly statistically significant improvements (p <0.001) which justify the research hypothesis of intervention. Conclusion: Educational intervention significantly get out improvements in pre, post-tests and after three months for students' knowledge, attitudes and practices regarding umbilical cord blood collection for stem cells. Recommendations: Umbilical cord blood collection and any current technologies must be incorporated into nursing curriculum in order to update the future nurse with this current medical innovation and evidences.
Prospects and Threats of Implementing the Export-Oriented Import Substitution Policy in the EEU Territory

The article assesses the potential for deepening the integration of the Eurasian Economic Union (EEU) member countries using the example of the agro-industrial complex, identifies integration and disintegration trends, as well as problems that impede the strengthening of partnership relations. The authors have analyzed state support measures aimed at solving these problems. The present study shows possibilities and directions of deepening integration based on the Russia's export-oriented import substitution policy. It was concluded that the development and improvement of measures of state support for the food industry and the agro-industrial complex should be formed considering the assessment of such supportive policy from the perspective of trade in value added. The authors have analyzed possible use of integration tools for enterprises of the agro-industrial complex. The study identifies industries with stable export potential. The analysis of the EEU export-import flows by disaggregated product segments shows the availability of mutual exchange of finished products within the same commodity group, which can be considered horizontal cooperation, but not vertical cooperation. Key-Words: export-oriented import substitution, the Eurasian Economic Union (EEU), economic integration, agro-industrial complex.
Runoff Generation Using Soil Moisture and Neural Network Models

Rainfall-runoff modeling is an integral part of a hydrologic model such as the Integrated Quantity and Quality Model (IQQM) being developed for the Lombok catchment in Indonesia. The main objective is to develop a tool for efficient water distribution and management. One of the problems encountered for runoff generation was a shortage of daily data for the purposes of model calibration and validation. Given this limitation, a comparative analysis is being undertaken to select the most appropriate rainfall-runoff model for the Lombok catchment. The paper examines rainfall-runoff generation processes using traditional soil moisture accounting models such as the Sacramento model as well as an artificial neural network backpropagation model (NNM). Simulated streamflows resulted in higher level of fitness in the case of the NNM.
Detection of Hydrothermal Alteration Zones using Image Processing Techniques, Chahr Gonbad, Iran

Use of satellite images to detect hydrothermal alteration zones can be helpful for efficient mineral explorations. Remote Sensing (RS) techniques make it possible to save cost and time for accurate primary explorations. The purpose of this research is to use the image processing techniques to detect porphyry copper minerals through the index of hydrothermal alteration mapping in Chahr Gonbad, Sirjan, Iran. We have obtained Landsat imagery data of Enhanced Thematic Mapper (ETM) and Operational Land Imager (OLI) for the analysis. For enhancement and detection of the alteration zones, we have applied useful RS methods including image difference and band color composite, band ratios, Principal Component Analysis (PCA), Crosta, and Matched Filtered. The results discovered argillite and propylitic alteration zones through iron-oxide and hydroxyl minerals in the study area. The image processing has revealed that the detected alteration minerals have relation with mineralization of porphyry copper. The zones are mainly developed in a northwest-southeast orientation and mostly concentrated in center and south of the Chahr Gonbad.
Critical challenges for SMEs in the UK chemical distribution industry

ing and Indexing The Journal of Business Chemistry is covered by the following abstracting and indexing services: EBSCO Publishing (www.ebsco.com) Hamburg Institute of International Economics (online databases and print archive) German National Library of Economics Chemical Business NewsBase (CBNB) by Elsevier Engineering Information, Inc.
Supply chain & inventory management in food industry: A case study

A company which provides food typically stores its products in a warehouse before shipping them to consumers. Inventory control play prominent role for the food processing& distribution firm because of the huge amount of food items typically stored. This excess amounts of stored items enhance inventory and supply chain management cost and results minimizing warehouse efficiency. Summing up, inventory control management should be the fundamental focus of the food processing & distributing firm, exceptionally for perishable packaged foods. The literature is however crucial to structure a system to express outcome in advance for forthcoming inventory. Some key issues associated with inventory control & supply management in the food processing & distribution firm have been revealed form surveying through experts, and analyzed sequential patterns to find fundamental concepts based on analytical results from the survey. This work proposed precise inventory predictive model, to uplift inventory prediction up to 64.9%. Through the sequential patterns based on thorough research, the food processing & distribution firm can manage inventory efficiently and accurately.
Contribution to the Engineering of User Interfaces. (Contribution à l'ingénierie des interfaces homme-machine)

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Contribution to the Engineering of User Interfaces Arnaud Blouin
Magnetic resonance findings and outcome in ten cats with traumatic spondylomyelopathy

Acute spinal cord injuries (SCIs) caused by exogenous traumas, mainly road traffic accidents (RTA), are the fourth most common cause of feline death (Rochlitz, 2004). Other causes of acute spinal trauma include falls, gunshots, falling objects and accidental owner-induced injuries (Rochlitz, 2004; Marioni et al., 2004; Adamantos et al., 2007; Eminaga et al., 2011). In cats, vertebral fractures and/or luxations account for 6% of all spinal cord disorders (Marioni BSTRACT
Workplace Deviance Behavior: Role of Psychological Empowerment and Transformational Leadership

Employees are likely to engage in deviance behavior, when they feel that they are not punished for their acts. Deviance behavior by employees overcomes the organization efficiency and performance. In order to overcome such deviance behavior in an organization, leader role becomes very important to change the attitudes, beliefs and behaviors of employees. The purpose of this research study is to investigate the relationship between psychological empowerment, transformational leadership and workplace deviance behavior. For this research study, the data is collected from the telecommunication sector of Pakistan. It is empirically investigated in this research study that psychological empowerment given to employees is the significant factor for decreasing the workplace deviance behavior in an organization and transformational leadership also plays a significant role to overcome such deviance behavior by employees.
Testing hypotheses for chaotic genetic structure : patterns of spatial and temporal genetic heterogeneity among recruits , subadults and adults of the intertidal anomuran Petrolisthes cinctipes

Hypotheses to explain chaotic genetic structure (i.e. a surprising degree of non-geographic temporal or spatial population differentiation) include: 1) variation in source of larval recruits, 2) self-recruitment and local subdivision, 3) variance in reproductive success (sweepstakes reproduction), and 4) preor post-settlement natural selection. We evaluated the relative contribution of each of these four processes to the observed patterns of population differentiation among geographic populations of the porcelain crab, Petrolisthes cinctipes. Approximately 50 individuals of each size class (new recruits, sub-adults, adults) were collected at each of nine sites across northern California in each of three consecutive years for genotyping (N= 3602). Significant and consistent population structure (θ ~ 0.08) was detected among sites from each replicate year of sampling (1997-1999). Significant population structure was also detected both among years and among sites, but the pattern of population structuring differed by size class. Among years, the differentiation of new recruits was highest (θ = 0.12) year-to-year, followed by the sub-adults (θ = 0.09) and finally adults (θ = 0.08). In contrast, the among sites component was greatest among the adults (θ = 0.05), followed by the sub-adults (θ = 0.03), and least among new recruits (θ < 0.01, not significant). An overall hierarchical analysis of molecular variance found genetic partitioning was structured among years (θ = 0.05), and size classes (θ = 0.08), but not among sites (θ < 0.01). Recruits at each site were most genetically similar to a different population of adults each year, and although some were apparently self-recruits, no consistent patterns of assignment or genetic similarity to natal populations were observed across years, indicating that there is no predictable source of recruitment. Temporal differentiation was stronger than spatial differentiation, and in the full hierarchical analysis, the among years and among size class components of variance explain the majority of observed population structure. Most studies of population genetic structuring are snap-shots based on single collections that lack explicit temporal components, and may provide an incomplete picture of population structure as a result. Overall, these data are consistent with the combined influence of all four hypothesized mechanisms acting synergistically to create fine-scale population genetic structure in marine species, because none of them alone appears sufficient to account for the observed population structure in P. cinctipes.
Evaluating the City Characteristics through Geo-Tagged Tweets

We try to evaluate the city characteristics from emotional expressions in texts on the net which are posted at the city. An emotional dictionary developed at WordNet Affect[1] project is used to extract emotional states from them. We have tested the proposed method on three cities in U.S.A. and two cities in U.K. Principal component analysis (PCA) has been used to investigate the difference of characteristics between the cities.
Cytotoxic Effects of the Dual ErbB Tyrosine Kinase Inhibitor, Lapatinib, on Walker 256 Rat Breast Tumour and IEC-6 Rat Normal Small Intestinal Cell Lines

Lapatinib is an orally administered, dual ErbB1/ErbB2 tyrosine kinase inhibitor (TKI). It is effective in ErbB2 + ve breast cancer treatment. However, lapatinib is associated with diarrhoea with an incidence of 47–75%. The mechanism of ErbB1 TKI-induced diarrhoea remains unclear. ErbB1 or epidermal growth factor receptor (EGFR) is expressed in gastrointestinal mucosa whereby the primary site for drug absorption is intestine. Thus, administration of ErbB1 oral TKI may disrupt gut homeostasis, leading to diarrhoea. Nevertheless, further investigations are required. We observed that lapatinib inhibited 50% Walker 256 breast tumour cells and IEC-6 small intestinal cell growth. Higher percentage of necrosis was observed in lapatinib-treated Walker 256. Lapatinib-treated IEC-6 showed higher percentage of late apoptosis. Only ErbB2 mRNA was detected in Walker 256 but both ErbB1 and ErbB2 mRNAs were detected in IEC-6, yet both protein staining were detected in both cells. Lapatinib exhibited cytotoxic properties on ErbB1/ErbB2 expressing cell lines, with intestinal cells being more sensitive to lapatinib compared to tumour cells. Lapatinib induced necrosis in tumour cells, while inducing late apoptosis in intestinal cells may explain lapatinib-induced diarrhoea in patients administered with the drug which could be due to apoptosis of intestinal epithelial cells leading to barrier disruption and consequently diarrhoea.
Integrating Life Cycle Assessment and Input-Output Analysis for the assessment of ethanol greenhouse gases emission in Brazil

The increasing ethanol production in Brazil is deeply related to the global demand for alternative energy sources which can both decrease the reliance of economic sectors on non-renewable energy and drive global energy production towards a more sustainable situation. Simultaneously, it is important to improve techniques that allow the assessment of environmental impacts from different scenarios of biofuel production, aiming to improve its sustainability. The Life Cycle Assessment (LCA) is recognized as a powerful methodology that provides detailed information about the environmental impacts related to agricultural production, industrial stage and consumption phase of sugarcane-based products and co-products. However, LCA has some limitations regarding the definition of system boundaries and also requires huge effort during the data collection for Life Cycle Inventory. In this sense, a different technique such as the LCA integration with Input-Output Analysis (IOA) emerges as an alternative approach which allows expanding the boundaries of LCA studies to the country's economy without losing important information provided in the life cycle inventory. This approach is based on the country's inputoutput matrix, which allows calculating the direct and indirect impacts related to all production sectors of a country. In this paper, such integrated approach will be used to simulate the greenhouse gases emission related to different technological scenarios of bioethanol production in the Virtual Sugarcane Biorefinery (VSB), under development by the Brazilian Bioethanol Science and Technology Laboratory (CTBE). Data for the assessment were obtained from literature and computing simulation. Preliminary results show that integrated first and second generation ethanol production (1G2G) has the lowest global warming potential (measured in CO2-eq) when compared with first generation ethanol production technologies in Brazil.
Allegato 4a 6 A protocol to monitor the phenology and nutritional content of grasslands

Studying the changes in phenology of vegetal communities is fundamental for the knowledge and the conservation of the populations which live into those habitats. In particular, in Gran Paradiso National Park the beginning of alpine grasslands growing season have been anticipating during the last 30 years, and in particular between 1990 and 2000 (see action 4.a.2). This change can be linked with the reduction of Alpine ibex population (Capra ibex ), which drastically reduced from 1992 to 2008 (Mignatti et al. 2012; Pettorelli et al. 2007). Continuing to study grassland phenology in the future will be important to better understand this link. To do it, prediction of nutritional content from remotely sensed data can be an easy way to obtain this information; however, results of model validations have shown that their strength to different climatic situations need to be tested using data of different seasons (with the exception of biomass, which seems quite strength to these variations). So, other field data collections appear to be useful for two reason: not only for the continuous improvement of the built models, but also to obtain sample data of real nutritional and phenological contents. For this purpose, a possible protocol for performing this phenological and nutritional grassland monitoring have be shown in this document.
THE SAGUENAY FJORD: INTEGRATING MARINE GEOTECHNICAL AND GEOPHYSICAL DATA FOR SPATIAL SLOPE STABILITY HAZARD ANALYSIS

In 1996 a major flood occurred in the Saguenay region, Québec, Canada, delivering several millions of m of sediment to the Saguenay Fjord. Such sediments covered large extensions of the, until then, largely contaminated fjord bottom, thus providing a natural capping layer. Recent swath bathymetry data has also evidenced that sediment landslides are widely present in the Saguenay Fjord. It seems that, as indicated by the expanded seismic record of this region, the most probable cause of such landslides is seismic shaking. The occurrence of new seismic events could, in consequence, compromise the stability of the fjord bottom as well as the newly deposited sediment layer. Therefore, in this study, we try to characterise the critical accelerations induced by these earthquakes from which shallow sediment landslides could be triggered. The analysis is based on gradients obtained from multibeam data as well as sediment physical properties measured in box cores. Resolving the region of the 1988 Saguenay earthquake as the most likely source area of such earthquakes, we have analysed several magnitude and focal depth scenarios to deduce that sediment displacements will start from local magnitudes of 4.8. Major displacements, failure, and subsequent landslides will occur only from local earthquake magnitudes of 6.6. RÉSUMÉ En 1996, une inondation majeure est survenue dans la région du Saguenay (Québec, Canada) entraînant par le fait même plusieurs millions de m de sédiments dans le fjord du Saguenay. Ces sédiments sont venus recouvrir en bonne partie les sédiments contaminés de cette partie du fjord. Des levés multifaisceaux dans le même secteur ont aussi révélé la présence de plusieurs glissements sous-marins dont l’origine est due presque exclusivement à de forts séismes, fréquents dans la région. On se pré-occupe donc de l’effet d’un éventuel séisme sur l’intégrité de la couche de 1996, laquelle pourrait être mobilisée directement ou indirectement lors d’instabilités sous-marines. Les travaux présentés ci-après s’intéressent à l’effet des accélérations critiques causées par des séismes sur la stabilité de la couche de 1996. L’analyse se base sur les levés multifaisceaux et les nombreux profils géotechniques disponibles (carottier à boîte) dans le secteur. Nous avons estimé qu’un séisme ayant une magnitude de 4.8 initierait des déplacements significatifs et qu’avec une magnitude de 6.6 et plus, de nombreux glissements seraient produits.
NEED OF UNDERSTANDING HOW TO ENHANCE INNOVATION AT EARLY PHASES OF PRODUCTION SYSTEM DEVELOPMENT

The main purpose this paper is to discuss a research potential in the area of understanding how a company can enhance innovation at the early phases of production system development. Due to this purpose, the structure of this paper deviates from the conventional ones that include methods, findings, and contributions. The chain of logic in this paper is structured as follows. Firstly, the importance of the early phases in terms of constantly developing new production systems is mentioned. Then, the early phases are defined and described in theoretical frameworks. Later, two industrial cases are introduced to emphases the aforementioned importance. Finally, the research potential is discussed based on the theories and practices introduced in the earlier parts of the