Miracle-dz/UniFAR-FTUs huggingface dataset:
A Rare Pulmonary Manisfestation of Kahler's disease

Kahler’s disease also known as Multiple Myeloma (MM) is a neoplastic plasma-cell disease known for its infiltration of malignant plasma cells in the bone marrow (BM) accompanied by multiorgan dysfunction. The median age at diagnosis is approximately 70 years. [1] Less than 2% of the patients are younger than 45 years of age at diagnosis. [2] MM may present as a diffuse disease of the bone (myelomatosis) or may be as a single plasmacytoma of bone or as an extramedullary plasmacytoma (EMP). The very common thoracic involvement by MM is the bone involvement or infiltration of the lungs secondary to an infection. Although the pulmonary parenchyma is quite a rare site of extramedullary involvement in MM patients, interstitial lung disease (ILD) as a pulmonary manifestation of MM is even rarer. Only few proved cases have been reported in the literature so far. Therefore, we present a rarest case possible of a MM presenting as ILD.
Three Mindsets of Entrepreneurial Leaders

Discontinuous change is becoming the norm. This has consequences for how organisations are managed and led. Strategic entrepreneurship—the simultaneous practice of advantage-seeking behaviour and opportunity-seeking behaviour—has been proposed as a solution. But practice of strategic entrepreneurship confronts challenges requiring a special type of leadership for its successful implementation—entrepreneurial leadership. People who display such leadership behaviours are called entrepreneurial leaders. We know little about such individuals. We purposively studied three different types of organisations that renewed themselves under such leaders and inductively arrived at three unique mindsets—purpose-oriented, people-oriented and learning-oriented—which help us unpack one aspect of what makes a leader entrepreneurial. We contribute to the entrepreneurial leadership literature by contributing a more nuanced view to mindsets of such leaders which is an important cognitive filter. Our findings also contribute to the literature on strategic entrepreneurship by indicating how leaders with certain combination of mindsets are better at implementing renewal. We advance practice by enabling organisations better identify and develop mindsets among potential leaders who can take on entrepreneurial roles. Limitations and future research are discussed.
Evaluating Meta-Analysis Research of Escherichia coli

This chapter summarizes the progress in Escherichia coli research that used the meta-analysis approach. Using systematic searches for E. coli literature, we tracked meta-analysis publications and analyzed them based on a number of parameters. These included subject/topic (epidemiology, clinical/intervention/prevention and environmen-tal), geographical region (the Americas, Europe and Australasia) and clinical syndrome (enteric, renal, and sepsis/meningitis). These parameters were plotted in terms of time span to obtain a sense of dynamic change or its absence through the years since the turn of the twentieth century. In terms of region, topic and syndrome, highest meta-analysis productivity was attributed to the Americas, clinical/intervention/prevention and enteric, all of which took place in the last 5 years (2011–2016). Over the combined time span of 16 years, the Americas significantly dominated meta-analysis outputs when compared to Europe and Australasia (P = 0.003). In conclusion, our findings facilitate awareness of the progress in this field wherein the studied parameters were analyzed for patterns over time and differential rates of publication productivity.
Bursty Expression Enhances Reliability of Messaging in Gene Networks

The promoter state of a gene and its expression levels are modulated by the amounts of transcription factors interacting with its regulatory regions. Hence, one may interpret a gene network as a communicating system in which the state of the promoter of a gene (the source) is communicated by the amounts of transcription factors that it expresses (the message) to modulate the state of the promoter and expression levels of another gene (the receptor). The reliability of the gene network dynamics can be quantified by the Shannon’s entropy of the message and the mutual information between the message and the promoter state. Here we consider a stochastic model for a binary gene and use its exact steady state solutions to calculate the entropy and mutual information. We show that a slow switching promoter having long and equally standing ON and OFF states maximizes the mutual information and reduces entropy. That is a bursty regime generating a high variance message governed by a bimodal probability distribution with peaks of the same height. Our results indicate that Shannon’s theory can be a powerful framework for understanding how bursty gene expression conciliates with the striking spatio-temporal precision exhibited in pattern formation of developing organisms.
Arthroplasty for severe deforming arthropathy in overlap syndrome of systemic lupus erythematosus and anti-Jo-1 antibody positive dermatomyositis

Abstract We experienced a rare case of severe contractured and flexed metacarpophalangeal joint (MPJ) arthropathy in a patient with overlap syndrome of systemic lupus erythematosus and dermatomyositis. The patient was a 60-year-old female with high anti-nuclear antibody and anti-Jo-1 antibody titers whose hands had gradually deformed without arthralgia during the past 6 years. Both hands were extremely contractured; in particular, the right hand had dislocations of the second to fifth MPJs, ankyloses of some proximal interphalangeal and distal interphalangeal joints, and z-shaped deformity of the thumb. We performed thumb arthroplasty and artificial joint replacement of the second to fifth MPJs of the dominant right hand. These operations enabled improvement of the patient’s ability to perform daily activities, with an improvement from 1.125 to 0.625 of the Japanese version of the Stanford Health Assessment Questionnaire score. Although surgery to treat contractured deformities can only partially recover the functional ability, it also has indications for arthroplasties.
The morphological evolution of the Adephaga (Coleoptera)

The evolution of the coleopteran suborder Adephaga is discussed based on a robust phylogenetic background. Analyses of morphological characters yield results nearly identical to recent molecular phylogenies, with the highly specialized Gyrinidae placed as sister to the remaining families, which form two large, reciprocally monophyletic subunits, the aquatic Haliplidae + Dytiscoidea (Meruidae, Noteridae, Aspidytidae, Amphizoidae, Hygrobiidae, Dytiscidae) on one hand, and the terrestrial Geadephaga (Trachypachidae + Carabidae) on the other. The ancestral habitat of Adephaga, either terrestrial or aquatic, remains ambiguous. The former option would imply two or three independent invasions of aquatic habitats, with very different structural adaptations in larvae of Gyrinidae, Haliplidae and Dytiscoidea.
Study of the correlation of epicardial adipose tissue with left ventricular mass and left ventricular mass index in patients with essential hypertension

Background: Epicardial adipose tissue (EAT) is recognized to be a cardiovascular risk factor. In addition to providing fuel to heart, it plays a pivotal role in the pathogenesis of atherosclerosis though the secretion of adipokines. This study aims to find the correlation of EAT with left ventricular mass (LVM) and left ventricular mass index (LVMI) in patients with essential hypertension. Increasing LVM and LVMI are predictors of poor cardiovascular outcome. So, if we find a positive correlation, we can say that measurement of epicardial fat in essential hypertension may help us identify high risk hypertensive patients. Methods: This study was carried out in SMS Hospital, Jaipur, after approval from the Ethics Committee. 100 consecutive eligible patients were included in the study after application of inclusion and exclusion criteria and taking proper informed consent. After history, examination and routine laboratory investigations, all patients underwent transthoracic 2D and Doppler echocardiography. EAT thickness, LVM and LVMI were measured and correlated using Spearman correlation coefficient. Results: The mean LVM was 139±42.12 g and mean LVMI was 35.76±11.28 g/m. The spearman correlation coefficient (r) was calculated to be 0.691 between EAT and LVM and 0.677 between EAT and LVMI, indicating strong positive correlation between EAT and both LVM and LVMI. This implies that as; EAT increases, LVM and LVMI increases significantly. Conclusions: Thus, we have found that EAT is positively correlated with LVM and LVMI. So, we can say that increase in EAT may lead to adverse cardiovascular outcome in patients with essential hypertension.
Analysis for Science Librarians of the 2019 Nobel Prize in Physics: From Cosmic Scales to Nearby Stars

ABSTRACT The 2019 Nobel Prize in Physics was awarded to P. James E. Peebles, Michel Mayor, and Didier Queloz for discoveries that have changed our perspective on the world we live in. Peebles’ research questions span across cosmology, from the cosmic microwave background (CMB) to studies of anisotropy and galaxy clustering to dark energy and quintessence. Mayor and Queloz discovered the first planet orbiting a Sun-like star – a hot, Jupiter-like planet that completes a single orbit in a manner of days. This paper describes the science behind the prize in the context of these scientists’ careers. A citation analysis of each laureate is presented, drawing on Web of Science and Scopus data, with network graphs.
Grouping ambiguous neural representations: neither identical chromaticity (the stimulus) nor color (the percept) is necessary.

Multiple regions, each with the same ambiguous chromatic neural representation, are resolved to have the identical perceived color more often than chance [Proc. Natl. Acad. Sci. USA93, 15508 (1996)PNASA60027-842410.1073/pnas.93. 26.15508; J. Opt. Soc. Am. A35, B85 (2018)JOAOD60740-323210.1364/JOSAA.35. 000B85]. This reveals that the regions are grouped, but it is unclear whether they are grouped because each one has the identical competing representations of the same stimuli (that is, the same chromaticities) or, alternatively, identical competing representations of the same colors one sees. The current study uses chromatic induction, as in Nat. Neurosci.6, 801 (2003)NANEFN1097-625610.1038/nn1099, to disentangle whether grouping depends on identical (though ambiguous) stimulus chromaticities or on perceived colors, by (1) inducing one chromaticity to appear in two different colors or (2) inducing two different chromaticities to appear in the same color. All stimuli were equiluminant gratings with chromatic inducing and test fields. Three observers were tested, first completing color matches to measure induced color-appearance shifts and second completing grouping measurements using interocular-switch rivalry, a method with rivalrous dichoptic images swapped between the eyes at 3.75 Hz [J. Vis.17, 9 (2017)1534-736210.1167/17.5. 9]. Each of two separate areas, one above and one below fixation, had dichoptic rivalry. The two sets of regions had either identical or different chromaticities that could appear either as the same color or not. Observers reported their percepts when both areas above and below fixation were grouped by color or by chromaticity (or neither in an additional experimental condition). All conditions showed significant groupings for every observer, including when neither color nor chromaticity was identical in a "group. " Moreover, there was never a significant effect of chromaticity versus color for any observer. This is the result expected if neither color nor chromaticity must match between two regions in order for them to be grouped and suggests that, instead, some other feature drives grouping.
Nano- and Micro-Scale Simulations of Ge/3C-SiC and Ge/4H-SiC NN-Heterojunction Diodes

During the last decade, silicon carbide (SiC) and its heterostructures with other semiconductors have gained a significant importance for wide range of electronics applications. These structures are highly suitable for high frequency and high power applications in extremely high temperature environments. SiC exists in more than 200 different polycrystalline forms, called polytypes. Among these 200 types, the most prominent polytypes with exceptional physical and electrical attributes are 3C-SiC, 4H-SiC and 6H-SiC. Heterostructures of these SiC polytypes with other conventional semiconductors (like Si, Ge) can give rise to interesting electronic characteristics. In this article, Germanium (Ge) has been used to make heterostructures with 3C-SiC and 4H-SiC using a novel technique called diffusion welding. Microscale and nanoscale simulations of nn-heterojunction of Ge/3C-SiC and Ge/4H-SiC have been done. Microscale devices have been simulated with a commercially available semiconductor device simulator tool called Silvaco TCAD. Whereas nanoscale devices have been simulated with QuantumWise Atomistix Toolkit (ATK) software package. Current-voltage (IV) curves of all simulated devices have been calculated and compared. In nanoscale device, the effects of defects on IV-characteristics due to non-ideal bonding (lattice misplacement) at heterojunction interface have been analyzed. Our simulation results reveal that the proposed heterostructure devices with diffusion welding of wafers are theoretically possible. These simulations are the preparations of our near future physical experiments targeted to fabricate SiC based heterostructure devices using diffusion bonding technique.
Critical examination of experimental data on strain bursts (pop-in) during spherical indentation

Pop-in during indentation testing is a term used to indicate the sudden displacement burst during loading. Experimental data are measured during an indentation pop-in event, using displacement sensors with 20 µs time constant at 100 kHz data acquisition rate. The load–depth response during the pop-in event that occurs within 160 µs is determined after accounting for the instruments’ dynamic response. Unlike the response reported in the literature for force-controlled tests, wherein the load on the sample remains constant during the pop-in, a steep load drop is observed after the onset of pop-in, followed by a significant increase in the load well beyond the load at the onset of pop-in. A model for the material and instrument’s dynamic response is presented that agrees well with the experimental observations. The implications of these findings for determination of pop-in length or velocity and for performing displacement-controlled testing involving closed loop control are discussed.
Screening of a novel BRCA2 mutation by rapid in-house PCR-RFLP Screening al unei noi mutaţii BRCA2 prin tehnică rapidă PCR-RFLP elaborată in-house

Abstract BRCA1 and BRCA2 are major cancer predisposition genes, responsible for a large percentage of heredi-tary breast and ovarian cancer (HBOC) families. The distribution of BRCA mutations has been studied in many populations, though only recently so in Romania. We started the first local oncogenetic study, searching for muta-tions of BRCA genes in HBOC families, by using mutation-specific PCR-based methods and dideoxy sequencing. We investigated 104 samples from familial (29 HBOC) and non-familial cancer cases (50 breast, 25 ovary), from North-Eastern Romania. Among the diversity of BRCA deleterious mutations, a novel BRCA2 mutation in exon 21, c.8680C>T, was identified. The T for C substitution creates a stop codon at position 2894, truncating the last C-ter-minal 525 amino acids of BRCA2 protein. The mutation is not yet stored in international databases. The mutation was firstly identified in a breast cancer predisposition family. We imagined a simple and rapid screening for c.8680C>T identification. This substitution creates an additional TaaI restriction site, allowing a quick identifica-tion of the mutation by PCR-RFLP and agarose gel electrophoresis. Rapid screening allowed the identification of the same mutation in a sporadic ovarian cancer patient. Our results could open the way for a population study to determine the frequency of c.8680C>T, its possible recurrence, and an eventual founder effect in Romania.
Comparison study of memory status in war-PTSD veterans with depression and non- veterans depressed patients

Background : Cognitive problems in patients with post-traumatic stress disorder (PTSD) include poor concentration and impaired memory. Prevalence of PTSD in all aspects of life is 8% in USA. Regarding the importance of memory in functional levels, this study was performed to review memory status in these patients. Methods : Fifty male war veterans with PTSD and major depression and 50 male non-veterans with depression participated in this study performed at psychiatric outpatient ward in Baqiyatallah hospital during 2008-2009. The patients met the DSM-IV diagnostic criteria. Depression severity, sex, age, educational level, and marital status were matched in both groups. A psychologist completed demographic and Mississippi questionnaires, PTSD checklist (PCL), beck depression Inventory and wechsler memory scale. The collected data were analyzed using SPSS software (version 11.0). A P-value smaller than 0.05 was considered significant. Results : The mean age of the veterans and non-veterans was 43.9±4.7 and 42±9.4 years, respectively. Memory status did not differ between the two groups (P>0.05). There was no statistically significant correlation between duration and severity of PTSD with memory impairment (P>0.05). A negative correlation was found between personal and general information with re-experiencing in the veterans (P Conclusion : Although both PTSD and major depression affected memory, but memory status did not differ between patients with PTSD and depression and patients with chronic depression.
Water sanitation and hygiene interventions to combat childhood diarrhoea in developing countries.

This report is a synthetic review of impact evaluations examining effectiveness of water sanitation and hygiene (WSH) interventions in reducing childhood diarrhoea. The review has been conducted to Campbell / Cochrane Collaboration standards of systematic review as well as employing mixed methods of data analysis to assess not only which interventions are effective or not but why and under what circumstances. The review provides an update of previous reviews conducted in this area. (Excerpt)
Measuring brand strategy: can brand equity and brand score be a tool to measure the effectiveness of strategy?

Measuring the effectiveness of brand strategy is a difficult task. This paper examines the approach to measurement of strategy through application of brand score and brand equity as a tool. The study was done in two phases. In the first phase brand score was calculated by 150 postgraduate management students. The second phase of study was to calculate brand equity using the same respondents for the same brands. The top three brands in food, cold drink and telecommunication service provider segments were selected for the study. Higher McDonald's brand score also had higher brand equity index when compared to Domino's and Pizza Hut. It means strategy is working quite well as reflected in two measurable tools. The individual component study for brand score and brand equity index can give insight on impact of strategy on these two measurable approaches of strategy. It can also help in reducing wastage of promotional expenditure. This could give scope for further research because of less work done in this area.
The i-screen: A Versatile Preclinical Platform for Gut Microbiota Studies

The gut microbiota is the complex community of microorganisms that inhabit the human intestine. Gut microbes participate in many aspects of human physiology, including health and disease. Food ingredients, drugs and other environmental factors can affect the gut microbiota, with possible consequences on human health. Progress in microbiome research has significantly stimulated and expanded the interest in technologies to study the potential of different products to modulate the gastro-intestinal ecosystem. In this context we have developed a method, called the i-screen, to evaluate the effects of compounds on the human gut microbiota. The i-screen is an in vitro system that allows the anaerobic cultivation of microorganisms obtained from fecal material, and therefore representative of the highly diverse colonic microbiota. By means of specific analyses, the effects of test compounds on the gut microbiota composition and metabolic activity can be assessed. The i-screen has proven to be an effective and versatile experimental model of the gut microbiota, routinely applied to evaluate the effects of food ingredients and drugs. This system constitutes a valid contribution to product development and a starting point for a better understanding of the role of gut microbiota in host health.
Communication-Delay-Dependent Rendezvous With Possible Negative Controller Gain in Cyclic Pursuit

In this article, we address the multiagent rendezvous problem for a group of single-integrator agents in the presence of a constant arbitrarily large bounded homogeneous communication delay. The agents are required to meet at a tunable desired point, which is unknown to all agents. To achieve this objective, we choose the cyclic pursuit strategy, which requires the minimum number of communication links. It is shown that the rendezvous can be achieved with at most one zero or negative gain in the presence of delay. A negative controller gain implies an antagonistic interaction of the agent with its neighbor, whereby it moves away from the neighbor. We find the bound on the negative gain such that rendezvous among all agents is possible. The margin on the negative gain decreases due to the presence of delay. An analytical expression has been obtained for the reachable rendezvous points in terms of an initial configuration of the agents, controller gains, and the delay. For fixed controller gains and increasing delay, the rendezvous point lies along the line joining the weighted centroid and the centroid of the initial configuration with the asymptotic nature toward the centroid when all gains are positive, while away from it when one gain is negative. For finite controller gains, the reachable set remains unchanged even in the presence of any finite delay. Numerical examples illustrate the presented results.
Identifying Strategic Traders in China’s Pilot Carbon Emissions Trading Scheme

This paper uses a sample of 1,867 firms that participate in the “Top-10,000 Energy-Consuming Enterprises Program” in China and aims to identify strategic traders in its pilot emissions trading scheme. Firms included in the ETS can exert their market power and manipulate allowance prices to achieve low compliance costs, which will consequently influence the effectiveness of this platform. This is of great importance to regulators or designers of this system in identifying these strategic traders and understanding their impact. We follow the basic principle proposed by Godal (2005) and develop a simple and implementable empirical procedure to study firm-level data from seven pilot programs in China. The results show that strategic traders exist with clear regional and sectoral differences. As a consequence of strategic trading by these firms, the overall volume of trading falls remarkably, with a clear increase in total compliance costs.