Miracle-dz/UniFAR-FTUs huggingface dataset:
Hearing problems at working age: Audiometric features and the aetiology of hearing impairment

Sixty patients, 37 women and 23 men, aged 30−65 years, were included in the study. All had adult-onset hearing loss to an extent that necessitated hearing-aid fitting. The objective was to describe the audiometric features and extent of hearing loss, and to determine the aetiology of hearing impairments in hard-of-hearing patients in working life. The extent of hearing loss varied considerably; about one-third of the patients had moderate to severe hearing loss in both ears, about one-third had bilateral, mild hearing loss, and somewhat less than one-third had unilateral or asymmetrical hearing loss, with mild loss or even normal hearing in one ear. In 77% of the cases a diagnosis, verified or tentative, could be established. Middle ear disease with conductive or mixed hearing loss was found in 20% of the cases. Noise-induced hearing loss was diagnosed in 10% of the cases. The most common, but highly tentative, diagnosis was hereditary hearing loss. Including cases of otosclerosis, genetic hearing loss was suspected in 50% of the patients. Other diagnoses were occasionally encountered. Most of the patients had gently sloping audiograms of the better ear, followed by steeply sloping and U-shaped audiograms. It is concluded that a thorough audiological and medical investigation is an essential part of the process of aural rehabilitation.
Comparison of SAFER Behavior Assessment Results in Shelter Dogs at Intake and After a 3-Day Acclimation Period

In this study, it was hypothesized that different results would be obtained by canine behavior assessments performed within 24 hr of shelter intake (Day 0) and after a 3-day acclimation period (Day 3). Safety Assessment for Evaluating Rehoming assessments were performed on 33 dogs at 2 municipal shelters. Agreements between Day 0 and Day 3 varied among subtests, and no consistent temporal patterns were observed. Weighted kappa statistics for each subtest ranged from . 28 to . 78, and percentage discordance was 0% to 18%. In a 2nd analysis, subtests skipped due to serious aggression were replaced with scores corresponding to serious aggression, and missing values for the Food subtest were replaced with scores for no aggression if the dog did not eat. For subtests skipped due to severe aggression, more than 50% of the dogs had scores indicating low aggression on the other assessment. Eight of 16 dogs who did not eat on Day 0 ate on Day 3; 2 showed aggression. Until the ideal time to test can be identified, it should be based on the individual dog's welfare status, and testing of dogs showing severe stress should be avoided.
Assessing the External Validity of Successive Negative Contrast – Implications for Animal Welfare

ABSTRACT When unexpectedly switched from a preferred to a less-preferred food reward, non-human animals may decrease consumption below that when only receiving the less-preferred reward – a successive negative contrast (SNC) effect. SNC has been proposed as an animal welfare indicator, however, to be effective it should show external validity; being demonstrable outside of highly standardized laboratory settings. We therefore investigated whether the SNC effect typically shown in laboratory rats was observed in owned (pet) rats from heterogeneous non-laboratory environments. Subjects (N = 14) were tested in a consummatory SNC paradigm with solid food rewards. “Shifted” rats received a high-value reward for 10 days (pre-shift), a low-value reward for six days (post-shift), then one additional day of high-value reward (re-shift). “Unshifted” rats always received the same low-value reward. “Shifted” rats consumed more food during pre-shift and re-shift trials, but ate less of the low-value food than “unshifted” animals in the post-shift trials – a SNC effect. This confirms the external validity of the SNC paradigm, extending reproducibility to outside the laboratory, indicating translatability across contexts, thus enhancing its potential use as a welfare indicator.
Bootstrap and Second‐Order Tests of Risk Difference

Summary Clinical trials data often come in the form of low‐dimensional tables of small counts. Standard approximate tests such as score and likelihood ratio tests are imperfect in several respects. First, they can give quite different answers from the same data. Second, the actual type‐1 error can differ significantly from nominal, even for quite large sample sizes. Third, exact inferences based on these can be strongly nonmonotonic functions of the null parameter and lead to confidence sets that are discontiguous. There are two modern approaches to small sample inference. One is to use so‐called higher order asymptotics ( Reid, 2003 , Annal of Statistics 31, 1695–1731) to provide an explicit adjustment to the likelihood ratio statistic. The theory for this is complex but the statistic is quick to compute. The second approach is to perform an exact calculation of significance assuming the nuisance parameters equal their null estimate ( Lee and Young, 2005 , Statistic and Probability Letters 71, 143–153), which is a kind of parametric bootstrap. The purpose of this article is to explain and evaluate these two methods, for testing whether a difference in probabilities p2− p1 exceeds a prechosen noninferiority margin δ0. On the basis of an extensive numerical study, we recommend bootstrap P‐values as superior to all other alternatives. First, they produce practically identical answers regardless of the basic test statistic chosen. Second, they have excellent size accuracy and higher power. Third, they vary much less erratically with the null parameter value δ0.
Bent Line Quantile Regression with Application to an Allometric Study of Land Mammals' Speed and Mass

Summary Quantile regression, which models the conditional quantiles of the response variable given covariates, usually assumes a linear model. However, this kind of linearity is often unrealistic in real life. One situation where linear quantile regression is not appropriate is when the response variable is piecewise linear but still continuous in covariates. To analyze such data, we propose a bent line quantile regression model. We derive its parameter estimates, prove that they are asymptotically valid given the existence of a change‐point, and discuss several methods for testing the existence of a change‐point in bent line quantile regression together with a power comparison by simulation. An example of land mammal maximal running speeds is given to illustrate an application of bent line quantile regression in which this model is theoretically justified and its parameters are of direct biological interests.
Identification of Differential Aberrations in Multiple‐Sample Array CGH Studies

Summary Most existing methods for identifying aberrant regions with array CGH data are confined to a single target sample. Focusing on the comparison of multiple samples from two different groups, we develop a new penalized regression approach with a fused adaptive lasso penalty to accommodate the spatial dependence of the clones. The nonrandom aberrant genomic segments are determined by assessing the significance of the differences between neighboring clones and neighboring segments. The algorithm proposed in this article is a first attempt to simultaneously detect the common aberrant regions within each group, and the regions where the two groups differ in copy number changes. The simulation study suggests that the proposed procedure outperforms the commonly used single‐sample aberration detection methods for segmentation in terms of both false positives and false negatives. To further assess the value of the proposed method, we analyze a data set from a study that identified the aberrant genomic regions associated with grade subgroups of breast cancer tumors.
Female-partnered women conceiving kinship: Does sharing a sperm donor mean we are family?

ABSTRACT This qualitative study explored how 36 initially female-partnered mothers defined their own, and their children's, relationships with families who share their unknown sperm donor (i.e., “linked” families). Shared genetics among children were sometimes sufficient to describe relationships among linked families as familial, especially from the children's perspectives. Most women described their own relationships with linked families as significant but not necessarily in traditional family terms. Family terms were sometimes seen as undermining ties to siblings and genetically unrelated mothers. As shared experiences have come to define “chosen family,” definitions of significant relationships must expand to include those defined by shared genetics alone.
Blessed by the Holy People

ABSTRACT Men-women and women-men have a long tradition in Diné (Navajo) culture where they were, and sometimes still are, held in high esteem. Their supernatural prototypes figure prominently in parts of the Diné Origin Story. It is in this cosmological worldview and tradition of acceptance that Carrie, a multi-dualistic spirit, grew up to be a female-bodied man supported and respected by his/her family and community. He/she has worked in various professions defined as “masculine” in Diné and Western contexts, such as fire fighter, heavy equipment operator, truck driver, and building contractor. In addition, Carrie is a keeper of Diné traditions, and has also been active educating Native and Non-Native audiences on 2SpiritLesbianGayBiTransIntersexQueer issues.
Identification of Partially Linear Structure in Additive Models with an Application to Gene Expression Prediction from Sequences

Summary The additive model is a semiparametric class of models that has become extremely popular because it is more flexible than the linear model and can be fitted to high‐dimensional data when fully nonparametric models become infeasible. We consider the problem of simultaneous variable selection and parametric component identification using spline approximation aided by two smoothly clipped absolute deviation (SCAD) penalties. The advantage of our approach is that one can automatically choose between additive models, partially linear additive models and linear models, in a single estimation step. Simulation studies are used to illustrate our method, and we also present its applications to motif regression.
Development of a Software Tool Using Deterministic Logic for the Optimization of Cochlear Implant Processor Programming

Objective: An intelligent agent, Fitting to Outcomes eXpert, was developed to optimize and automate Cochlear implant (CI) programming. The current article describes the rationale, development, and features of this tool. Background: Cochlear implant fitting is a time-consuming procedure to define the value of a subset of the available electric parameters based primarily on behavioral responses. It is comfort-driven with high intraindividual and interindividual variability both with respect to the patient and to the clinician. Its validity in terms of process control can be questioned. Good clinical practice would require an outcome-driven approach. An intelligent agent may help solve the complexity of addressing more electric parameters based on a range of outcome measures. Methods: A software application was developed that consists of deterministic rules that analyze the map settings in the processor together with psychoacoustic test results (audiogram, A§E phoneme discrimination, A§E loudness scaling, speech audiogram) obtained with that map. The rules were based on the daily clinical practice and the expertise of the CI programmers. The data transfer to and from this agent is either manual or through seamless digital communication with the CI fitting database and the psychoacoustic test suite. It recommends and executes modifications to the map settings to improve the outcome. Results: Fitting to Outcomes eXpert is an operational intelligent agent, the principles of which are described. Its development and modes of operation are outlined, and a case example is given. Fitting to Outcomes eXpert is in use for more than a year now and seems to be capable to improve the measured outcome. Conclusion: It is argued that this novel tool allows a systematic approach focusing on outcome, reducing the fitting time, and improving the quality of fitting. It introduces principles of artificial intelligence in the process of CI fitting.
On the Efficiency of Score Tests for Homogeneity in Two‐Component Parametric Models for Discrete Data

Summary In many applications of two‐component mixture models for discrete data such as zero‐inflated models, it is often of interest to conduct inferences for the mixing weights. Score tests derived from the marginal model that allows for negative mixing weights have been particularly useful for this purpose. But the existing testing procedures often rely on restrictive assumptions such as the constancy of the mixing weights and typically ignore the structural constraints of the marginal model. In this article, we develop a score test of homogeneity that overcomes the limitations of existing procedures. The technique is based on a decomposition of the mixing weights into terms that have an obvious statistical interpretation. We exploit this decomposition to lay the foundation of the test. Simulation results show that the proposed covariate‐adjusted test statistic can greatly improve the efficiency over test statistics based on constant mixing weights. A real‐life example in dental caries research is used to illustrate the methodology.
Fisteldrosselung : erfolgversprechendes konzept bei peripherer minderperfusion

Aim: Evaluation of the diagnostic and therapeutic management of peripheral steal syndrome after placement of an autologous arteriovenous (av-) fistula and presentation of treatment results after its surgical correction. Methods: During a time period from 1994 to 1999, 1253 av-fistulas for hemodialysis were placed in our surgical department. Twenty-one patients (1.68%) underwent service operations because of considerable lower perfusion of the hand. In 14 patients the av-fistula was ligated, whereas in 7 patients, a polytetrafluorethylene (PTFE) sleeve was implanted at the venous site for fistula "banding" to diminish blood flow. In addition to the clinical finding, pre-, intra- and postoperative blood flow rates were determined using Duplex ultrasonography. Results: In patients showing flow rates of < 250 ml (carefully disclosed empiric value) ligation was chosen, whereas in cases with distinctly increased flow rates, banding of the arterialized vein was performed (authors' individually selected borderline flow). The extension of the banding was specified according to the intraoperatively determined flow rates. Recurrent steal syndrome was not observed over the entire postoperative observation period of 1-3 years. Conclusion: Arterial steal syndrome is a rare complication after placement of an av-fistula. In the majority of cases, surgical therapy is necessary. Pre- and intraoperative analysis of flow rates using Duplex ultrasonography may help to select the appropriate surgical approach and may, thus, determine the success rate of service operation.
An Omnibus Consistent Adaptive Percentile Modified Wilcoxon Rank Sum Test with Applications in Gene Expression Studies

Summary We present an adaptive percentile modified Wilcoxon rank sum test for the two‐sample problem. The test is basically a Wilcoxon rank sum test applied on a fraction of the sample observations, and the fraction is adaptively determined by the sample observations. Most of the theory is developed under a location‐shift model, but we demonstrate that the test is also meaningful for testing against more general alternatives. The test may be particularly useful for the analysis of massive datasets in which quasi‐automatic hypothesis testing is required. We investigate the power characteristics of the new test in a simulation study, and we apply the test to a microarray experiment on colorectal cancer. These empirical studies demonstrate that the new test has good overall power and that it succeeds better in finding differentially expressed genes as compared to other popular tests. We conclude that the new nonparametric test is widely applicable and that its power is comparable to the power of the Baumgartner‐Weiß‐Schindler test.
Successful research recruitment strategies in a study focused on abused rural women at risk for sexually transmitted infections.

INTRODUCTION The purpose of this article is to describe the successful recruitment methods of a study focused on a pilot intervention for rural women who were experiencing abuse and who also were at risk for sexually transmitted infections. Initial recruitment into the study was the primary challenge, and strategies to overcome recruitment difficulties are discussed. METHODS Eighty-seven women were screened, and 20 women were recruited from clinics into a 1-group pretest/posttest pilot study. The main inclusion criterion for the intervention was a past-year history of intimate partner violence (IPV). RESULTS After 1 month of recruitment, only 10 women agreed to be screened for IPV. Several creative strategies were utilized in the revision of the recruitment plan, with the most successful being knitting by the research staff and incentives to participants for screening. An additional 77 women agreed to be screened for study participation within 3 months of implementing the recruitment changes. DISCUSSION Personal involvement by the research staff and a nonthreatening and welcoming environment were necessary components for timely recruitment. Researcher flexibility and reevaluation allowed for changes to the recruitment plan that ultimately proved successful.
Analysis of the BRAFV600E Mutation in Central Nervous System Tumors

BRAFV600E mutations are involved in the development of melanoma, colon cancer, and papillary thyroid carcinoma. These mutations are also found in primary brain tumors at low to moderate frequencies. In this study, we investigated a series of brain tumors to determine the prevalence and associated clinicopathologic features of BRAFV600E mutations. By direct sequencing, we analyzed 223 brain tumors, including 51 gangliogliomas (GGs), 45 pilocytic astrocytomas (PAs), 12 pleomorphic xanthoastrocytomas (PXAs), 35 glioblastomas (GBs), 28 anaplastic astrocytomas (AAs), 44 oligodendroglial tumors (ODGs), 3 anaplastic oligoastrocytomas, and 5 diffuse astrocytomas. Thirty-six cases (16.1%) exhibited the BRAFV600E mutation, including 66.7% of PXAs, 23.5% of GGs, 15.6% of PAs, and 9.7% of the malignant gliomas; the latter included 14.3% of AAs, 8.6% of GBs, and 4.5% of ODGs. Copy number aberration at the 7q34 (BRAF) locus was found in 73.1% of PAs and 50% of PXAs. 9p Homozygous deletion was found in 66.7% of PXAs, but it was not correlated with the BRAFV600E mutation. Patients' age, sex, histologic grade, and progression-free survival were also not correlated with the BRAFV600E mutation. The BRAFV600E mutation in brain tumors did not have prognostic value but is certainly a diagnostic marker and therapeutic target, not only for pediatric low-grade gliomas but also for malignant gliomas, even though the rate of mutation was not high. These results should be verified in a larger study with more cases and a longer follow-up period to overcome the limitation of small sample size.
Correlation Relationship Assessment between Left Ventricular Hypertrophy Voltage Criteria and Body Mass Index in 41,806 Swiss Conscripts

Introduction: Electrocardiographic criteria for left ventricular hypertrophy (LVH) have been limited by low sensitivity at acceptable levels of specificity. A number of studies have demonstrated that body mass index (BMI) is associated with decreased sensitivity of ECG LVH classification in hypertensive patients. The objective of this study is to investigate the correlation relationship between LVH voltage criteria and BMI in Swiss conscripts.
The Influence of Partner Knowledge Complementarities on the Effectiveness of IT Outsourcing

Despite the importance of knowledge complementarities to inter-firm cooperation, few researchers in information systems (IS) have examined, to date, the construct of knowledge complementarities (KC), and none have examined its role in the success of IT outsourcing alliances. In this paper, we distinguish between potential knowledge complementarities (PKC) and synergistic value, which comprise KC. PKC is conceptualized as a multidimensional construct encompassing knowledge types (similar and specialized) and knowledge domains (business and IT). Further, we examine the extent to which PKC between the client and the vendor promotes success in IT outsourcing alliances. This research also includes relative absorptive capacity because it is relevant when complementary knowledge flows between organizations. We used data from a field study of 81 firms in Korea to test the proposed model. Our findings indicate that each dimension of PKC contributes uniquely to knowledge complementarities. The results also show that PKC is significantly associated with IT outsourcing effectiveness. Relative absorptive capacity is found to be a moderator between PKC and IT outsourcing effectiveness. The theoretical and practical implications of these findings are discussed in the paper.
A Strategic Social Action Framework: Theorizing and analyzing the alignment of social media affordances and organizational social action

ABSTRACT Social media is a relatively new and dynamic field dealing with the development and use of social media technologies by individuals and more recently by organizations. Although several frameworks and models have been proposed for studying social media, most provide only limited insights into the complex social activities that are supported by the strategic usage of social media in organizational settings. In this article, we take up this challenge and introduce a Strategic Social Action Framework for analyzing social media technologies and their strategic usage in and by organizations. This framework is based on Habermas’ theory of social action and the idea that social media platforms serve as sets of rules and resources that mediate strategic organizational (inter-)actions involving these platforms. We demonstrate the value of the framework by theoretically delineating the appropriateness of the framework to specific social media tools, as well as by empirically analyzing the strategic use of two publicly available social media platforms—Facebook and Twitter—by three large airlines—Delta, KLM Royal Dutch Airlines, and JetBlue. Our findings reveal that when implementing social media in organizational contexts, developers and managers should critically evaluate (a) the need for supporting a rich variety of action types, (b) the possible role of social media support in the specific action situation, and (c) the strategic alignment of social media affordances and specific social action categories. Finally, we discuss theoretical and practical implications as well as directions for future research.