Miracle-dz/UniFAR-FTUs huggingface dataset:
Gene Therapy for Pancreatic Diseases: Current Status

The pancreas is a key organ involved in digestion and endocrine functions in the body. The major diseases of the pancreas include pancreatitis, pancreatic cancer, cystic diseases, pancreatic divisum, islet cell tumors, endocrine tumors, diabetes mellitus, and pancreatic pain induced by these diseases. While various therapeutic methodologies have been established to date, however, the improvement of conventional treatments and establishment of novel therapies are essential to improve the efficacy. For example, conventional therapeutic options, including chemotherapy, are not effective against pancreatic cancer, and despite improvements in the last decade, the mortality rate has not declined and is estimated to become the second cause of cancer-related deaths by 2030. Therefore, continuous efforts focus on the development of novel therapeutic options. In this review, we will summarize the progress toward the development of gene therapies for pancreatic diseases, with an emphasis on recent preclinical studies and clinical trials. We aim to identify new areas for improvement of the current methodologies and new strategies that will lead to safe and effective gene therapeutic approaches in pancreatic diseases.
The Exploratory Study Experience: Developing as a Researcher

Abstract This article presents the experience of the researcher during the exploratory study, within the scope of her research in a qualitative paradigm, using the Grounded Theory as a methodological approach, which aims to understand the process of nursing care to the end-of-life patient in the performing activity of living eating and drinking. While structuring the research project, it became important to explore the field of data collection (hospice care unit of a hospital in the Lisbon region) in order to achieve a contact with the reality (represented by the actors), allowing an overview and approximation of the phenomenon under study, the break with the investigator's prentices and the modification of these ideas as well as the construction of the researcher's acceptance by the actors (potential participants), and the decision making during the research course. The sharing of this experience as well as the critical reflections presented here, enabled the researcher to review the difficulties encountered and the strategies used to overcome them, to become aware of the lessons learned and to consolidate them. It is also hoped that the sharing of this experience will help other researchers in their path, allow them to perceive that the mishaps / difficulties of the course they are carrying out are common, that a lot of critical reflection is needed on this trajectory, eventually finding strategies for the problems they might face.
Learning-Based Approach for Face Image Relighting

In this study, we propose a system for face image relighting. Given an unseen testing image, the system automatically changes its light condition. Such system is difficult since the shadow and lighting areas of a particular lighting condition are highly depended on the lighting source position and the facial 3D geometry. To solve this problem, we introduce a learning-based approach to construct the appearance correlation between two lighting conditions in order, which is then used to transform the lighting condition from the source lighting domain to the target lighting domain. First of all, the discriminative facial features of lighting and personal characteristics are selected. Consequently, these discriminative features are then used to guide the light reconstruction process. According to the experimental results, the proposed system, where the discriminative features are integrated in the synthesis process, makes the synthesized results preserve the personal characteristics of system input.
Doublecortin Interacts with μ Subunits of Clathrin Adaptor Complexes in the Developing Nervous System

Doublecortin is a microtubule-associated protein required for normal corticogenesis in the developing brain. We carried out a yeast two-hybrid screen to identify interacting proteins. One of the isolated clones encodes the mu1 subunit of the adaptor complex AP-1 involved in clathrin-dependent protein sorting. We found that Doublecortin also interacts in yeast with mu2 from the AP-2 complex. Mutagenesis and pull-down experiments showed that these interactions were mediated through a tyrosine-based sorting signal (YLPL) in the C-terminal part of Doublecortin. The functional relevance of these interactions was suggested by the coimmunoprecipitation of Doublecortin with AP-1 and AP-2 from mouse brain extracts. This interaction was further supported by RNA in situ hybridization and immunofluorescence studies. Taken together these data indicate that a certain proportion of Doublecortin interacts with AP-1 and/or AP-2 in vivo and are consistent with a potential involvement of Doublecortin in protein sorting or vesicular trafficking.
Confirmatory Factor Analysis Applied to the Force Concept Inventory.

In 1995, Huffman and Heller used exploratory factor analysis to draw into question the factors of the Force Concept Inventory (FCI). Since then several papers have been published examining the factors of the FCI on larger sets of student responses and understandable factors were extracted as a result. However, none of these proposed factor models have been verified to not be unique to their original sample through the use of independent sets of data. This paper seeks to confirm the factor models proposed by Scott et al. in 2012, and Hestenes et al. in 1992, as well as another expert model proposed within this study through the use of confirmatory factor analysis (CFA) and a sample of 20 822 postinstruction student responses to the FCI. Upon application of CFA using the full sample, all three models were found to fit the data with acceptable global fit statistics. However, when CFA was performed using these models on smaller sample sizes the models proposed by Scott et al. and Eaton and Willoughby were found to be far more stable than the model proposed by Hestenes et al. The goodness of fit of these models to the data suggests that the FCI can be scored on factors that are not unique to a single class. These scores could then be used to comment on how instruction methods effect the performance of students along a single factor and more in-depth analyses of curriculum changes may be possible as a result. DOI
Mapping Urban Extent Using Luojia 1-01 Nighttime Light Imagery

Luojia 1-01 satellite, launched on 2 June 2018, provides a new data source of nighttime light at 130 m resolution and shows potential for mapping urban extent. In this paper, using Luojia 1-01 and VIIRS nighttime light imagery, we compared several methods for extracting urban areas, including Human Settlement Index (HSI), Simple Thresholding Segmentation (STS) and SVM supervised classification. According to the accuracy assessment, the HSI method using LJ1-01 data had the best performance in urban extent extraction, which presented the largest Kappa Coefficient value, 0.834, among all the results. For the urban areas extracted by VIIRS based HSI method, the largest Kappa Coefficient value was 0.772. In contrast, the largest Kappa Coefficient values obtained by STS method were 0.79 and 0.7512 respectively when using LJ1-01 and VIIRS data, while for SVM method the values were 0.7829 and 0.7486 when using Landsat-LJ and Landsat-VIIRS composite data respectively. The experimented results demonstrated that the utilization of nighttime light imagery can largely improve the accuracy of urban extent extraction and LJ1-01 data, with a higher resolution and more abundant spatial information, can lead to better identification results than its predecessors.
PENERAPAN ALGORITMA LEVENSTEIN PADA APLIKASI KOMPRESI FILE MP3

Compressed files require less disk space than files that are not compressed, so compressing is useful for backing up data by using storage space to be small or to send information over the Internet faster. MP3 makes the audio format often used because the data stored resembles the original data when recorded and has a size that is not too large compared to other formats. Users besides storing song files, they also store videos and other files and users also want the highest quality data and minimum quantity (size). So to make a lot of empty space and have a size of data that is not large on storage media, a compression method that means to shorten the size of the bits needed for data is needed. Algorithms used in the compression process, including the Levenstein algorithm which is a type of lossless compression. Applying the Levenstein algorithm to the compression process the author wants to know the performance of compression when done by compressing MP3 files, so that large MP3 files will be compressed into smaller sizes, so that the transmission process is carried out faster and reduces the data storage location.Keywords: MP3, File, Levenstein
Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model

Recent data suggest that cholesterol metabolism is linked to susceptibility to Alzheimer's disease (AD). However, no direct evidence has been reported linking cholesterol metabolism and the pathogenesis of AD. To test the hypothesis that amyloid beta-peptide (Abeta) deposition can be modulated by diet-induced hypercholesterolemia, we used a transgenic-mouse model for AD amyloidosis and examined the effects of a high-fat/high-cholesterol diet on central nervous system (CNS) Abeta accumulation. Our data showed that diet-induced hypercholesterolemia resulted in significantly increased levels of formic acid-extractable Abeta peptides in the CNS. Furthermore, the levels of total Abeta were strongly correlated with the levels of both plasma and CNS total cholesterol. Biochemical analysis revealed that, compared with control, the hypercholesterolemic mice had significantly decreased levels of sAPPalpha and increased levels of C-terminal fragments (beta-CTFs), suggesting alterations in amyloid precursor protein processing in response to hypercholesterolemia. Neuropathological analysis indicated that the hypercholesterolemic diet significantly increased beta-amyloid load by increasing both deposit number and size. These data demonstrate that high dietary cholesterol increases Abeta accumulation and accelerates the AD-related pathology observed in this animal model. Thus, we propose that diet can be used to modulate the risk of developing AD.
Artificial bandwidth extension for speech signals using speech recogniton

In this paper, we propose a non-realtime speech bandwidth extension method using HMM-based speech recognition and HMM-based speech synthesis. In the proposed method, ﬁrst, the phoneme-state sequence is estimated from the bandlimited speech signals using the speech recognition technique. Next, for estimating spectrum envelopes of lost high-frequency components, an HMM-based speech synthesis technique generates a synthetic speech signal (spectrum sequence) according to the predicted phoneme-state sequence. Since both speech recognition and speech synthesis take into account dynamic feature vectors, we can obtain a smoothly varying spectrum sequence. For evaluating the proposed method, we conducted subjective and objective experiments. The experimental results show the effectiveness of the proposed method for bandwidth extension. However, the proposed method needs more improvement in speech quality.
Do Physicians Prefer to Complete Online or Mail Surveys? Findings From a National Longitudinal Survey

Survey response rates for physicians are falling generally, and surveys of physicians tend to have lower response rates than those of the general population. To maximize response, respondents are often given a choice of modes in which to respond. The aim of this article is to describe mode response patterns and identify factors related to physicians’ decisions to complete surveys online rather than by mail. The data are from the fifth annual wave of the Medicine in Australia: Balancing Employment and Life longitudinal survey of physicians, in which there was a 43.5% response rate (10,746/24,711) and 33.7% of respondents completed the survey online. Online completion was more likely when the physician had completed the survey online in the previous wave, was a general practitioner rather than other medical specialist or doctor-in-training, worked in a remote location, and was young and male. Free-text spontaneous comments from respondents indicated that mode choice was based on a combination of preference, previous experience, and feasibility. These results provide support for the use of mixed mode survey designs, which can accommodate doctors with different mode preferences and cast doubt over the possibility of tailoring mode based on respondent characteristics.
The diagnosis of depression in patients with dementia: Use of the cambridge mental disorders of the elderly examination (CAMDEX)

The prevalence of depression in 80 well‐diagnosed demented patients was examined using the Cambridge Mental Disorders of the Elderly Examination (CAMDEX) based on information from patients, caregivers and professionals. The overall prevalence of DSM‐III‐R major depressive illness was 5%, but the identification of depressed patients and the prevalence rate varied with the source of information used. The symptom profiles of the patients were examined in more detail. The significance of these findings and the use of operational diagnostic criteria in the investigation of coexistent depression and dementia are discussed.
Shape from Multi-Bounce Light Paths

Prof. Ioannis Gkioulekas, CMU-RI Classical shape estimation techniques often have simplified but unrealistic assumptions, such as light interacting with the scene with only single-bounce light paths and the scene being Lambertian. However, a real scene often interacts with light in significantly more complex ways; multi-bounce light paths are ubiquitous and real world materials are typically non-Lambertian. In such cases, shape estimation is not just challenging, but also beyond the reach of commonly used techniques.
Comprehensive Commentary on Kant's Religion Within the Bounds of Bare Reason

© 2016 John Wiley & Sons, Inc. Published 2016 by John Wiley & Sons, Inc. This Index has four sections. The purpose of the first section is to assist readers in identifying words that are underlined in my revision of Pluhar’s translation of Religion: all words/phrases included on the “SP” lines in Part 1 of the Glossary (pp.502–14) are included, except those that merely follow WP; each term is followed by its German equivalent, enabling readers to locate the relevant Glossary listing more easily. Those terms that are also listed in Part 2 of the Glossary (pp.515–36) are followed by a “*”; terms followed by + in the first and fourth sections of this Index are listed in both sections. Page numbers in the first section are not exhaustive; they refer either to key footnotes where the meaning or usage of the corresponding German word is discussed or to the term’s Glossary listing(s). The second section lists every reference to a passage from the Bible and does aim to list all such citations. Whenever Kant’s text, as quoted herein, either cites the stated biblical passage or quotes directly from at least part of it, the page number appears in italics. The third section includes all names of persons, including mythical and literary persons and divinities. As in the second section, the page number appears in italics whenever the stated name appears in Kant’s text. Citations to publications that are mentioned in this commentary are nested under the author’s name, using the publication year or, for publications not listed in Works Cited (pp. 537–51), a short title. Finally, the fourth section is a general listing of subjects and terms, many of which include detailed listings broken down into subentries (alphabetized by main words). For cross references within this final (and longest) section, “see also” normally points to another entry where the current entry word occurs as part of a subentry, with additional page references given. Occasionally, a cross reference points instead to a closely related entry where the current word does not occur in any of its subentries.
BMP7 antagonizes proliferative vitreoretinopathy through retinal pigment epithelial fibrosis in vivo and in vitro

The major pathogenesis of proliferative vitreoretinopathy (PVR) is that retinal pigment epithelial (RPE) cells undergo epithelial‐mesenchymal transition (EMT) because of disordered growth factors, such as TGF‐β, in the vitreous humor. Bone morphogenetic proteins (BMPs) are pluripotent growth factors. In this study, we identified the antifibrotic activity of BMP7 in a PVR model both in vivo and in vitro. BMP7 expression was confirmed on the PVR proliferative membranes. BMP7 was down‐regulated in the PVR vitreous humor and TGF‐β–induced RPE cell EMT. In the in vivo studies, BMP7 injection attenuated PVR progression in the eyes of the rabbit model. Additionally, BMP7 treatment maintained RPE cell phenotypes and relieved TGF‐β2–induced EMT, migration, and gel contraction in vitro. BMP7 inhibited the TGF‐β2–induced up‐regulation of fibronectin and α–smooth muscle actin and the down‐regulation of E‐cadherin and zona occludens‐1 by balancing the TGF‐β2/Smad2/3 and BMP7/Smad1/5/9 pathways. These findings provide direct evidence of the ability of BMP7 in PVR inhibition and the potential of BMP7 for use in PVR therapeutic intervention. —Yao, H. , Ge, T. , Zhang, Y. , Li, M. , Yang, S. , Li, H. , Wang, F. BMP7 antagonizes proliferative vitreoretinopathy through retinal pigment epithelial fibrosis in vivo and in vitro. FASEB J. 33, 3212–3224 (2019). www.fasebj. org
Probabilistic Proof Systems: A Primer

Various types of probabilistic proof systems have played a central role in the development of computer science in the last couple of decades. These proof systems deviate from the traditional concept of a proof by introducing randomization and interaction into the verification process. Probabilistic proof systems carry an error probability (which is explicitly bounded and can be decreased by repetitions), but they offer various advantages over deterministic proof systems. This primer concentrates on three types of probabilistic proof systems: interactive proofs, zero-knowledge proofs, and Probabilistically Checkable Proofs (PCP). Surveying the basic results regarding these proof systems, we stress the essential role of randomness in each of them.
Analysis and Design of a CMOS Ultra-High-Speed Burst Mode Imager with In-Situ Storage Topology Featuring In-Pixel CDS Amplification

This paper presents an in-situ storage topology for ultra-high-speed burst mode imagers, enabling low noise operation while keeping a high frame depth. The proposed pixel architecture contains a 4T pinned photodiode, a correlated double sampling (CDS) amplification stage, and an in-situ memory bank. Focusing on the sampling noise, the system level trade-off of the proposed pixel architecture is discussed, showing its advantages on the noise, power, and scaling capability. Integrated with an AC coupling CDS stage, the amplification is obtained by exploiting the strong capacitance to the voltage relation of a single NMOS transistor. A comprehensive noise model is developed for optimizing the trade-off between the area and noise. As a proof-of-concept, a prototype imager with a 30 µm pixel pitch was fabricated in a CMOS 130 nm technology. A 108-cell memory bank is implemented allowing dense layout and parallel readout. Two types of CDS amplification stages were investigated. Despite the limited memory capacitance of 10 fF/cell, the photon transfer curves of both pixel types were measured over different operation speeds up to 20 Mfps showing a noise performance of 8.4 e−.
IDENTIFICACION E IMPORTANCIA POBLACIONAL DE LOS PETIRROJOS ERITHACUS RUBECULA LOCALES DURANTE LA INVERNADA EN EL SUR DE ESPAÑA

El estudio de las posibles interacciones entre distintas poblaciones de una misma especie de ave cuando concurren en simpatría en las áreas de migración o de invernada es un tema de gran interés teórico y aplicado del que, sin embargo, se tiene escasa información (Ketterson & Nolan, 1983; Greenberg, 1986; Safriel, 1995; Sherry & Holmes, 1996). Por ejemplo, y pese a su importancia como área de invernada, todavía se sabe poco sobre las diferencias en la selección de hábitat, rastreo de los recursos, interacciones territoriales, estrategias de acumulación de grasa, gregarismo, etc. entre los paseriformes migradores y los sedentarios en la región Mediterránea (véase, sin embargo, Finlayson, 1981; Cuadrado, 1994). Esto puede explicarse, en parArdeola 47(1), 2000, 9-18
Remote Health Watchdog Framework for Seizure Patient Using Electronic Sensors

Epilepsy is due to the neurological disorder of a patient which makes the patient uncontrolled and makes unconscious. The patient should get support through an ongoing framework. The brilliant epilepsy recognition and ready framework is a propelled innovation by which an electronic device is introduced. Utilizing that pack, the life of the individual who is truly affecting with the condition can be anticipated. As per World Health Organization (WHO), epilepsy is a standout amongst the most well-known essential sicknesses of the focal sensory system around the world, which is exasperated by the sudden variable that portrays the event of an epileptic occasion. In this manner, the capacity to recognize scene preceding its beginning is introduced as a relief variable to the upsetting effects that emerge from this situation. The casing will be tolerable, confirms the condition and also alerts to the the family doctor. To realize all the above plan, mainly utilized four modules: three sensors, data analysis and ARDUINO module with GSM and GPRS module.
PREVALENCE OF AND FACTORS ASSOCIATED WITH CIGARETTE SMOKING AMONG SPORT FACULTY STUDENTS: A STUDY FROM TURKEY

Amaç: Tütün kullanımı iskemik kalp hastalığı, kanser, inme ve solunum yolu hastalıkları gibi birçok hastalıktan ölüm riskini artırmaktadır. Sadece 2016’da tütün kullanımı dünya çapında 7,1 milyondan fazla ölüme neden olmuştur. Bu ölümlerin çoğun (6,3 milyon) sigara içilmesine, ardından da pasif içiciliğe atfedilebilir. Yöntem: Bu çalışmanın amacı, İstanbul Üniversitesi Spor Bilimleri Fakültesi’nde sigara içme prevalansını ve sigara içme ile ilişkili faktörleri değerlendirmektir. Fakültede eğitim alan 360 öğrenci bulunmakta olup, bir örneklem seçimi yapmadan tüm öğrencilere ulaşılması amaçlanmıştır. Bulgular: Araştırmaya katılmayı kabul eden öğrenci sayısı 294 (% 81,94) ‘dür. Neredeyse %8’i (n = 24) günde 10’dan fazla sigara içtiği belirlenmiştir. Sigara içme prevalansı yaş, oturma yeri, annenin eğitimi, babanın eğitim düzeyi, sigara içilmesi, tütün kullanımı gibi faktörlerle, öğretmenlerin sigara alışkanlığı ve alkol tüketimi ile ilgili bilgi durumları ile anlamlı düzeyde ilişkilidir. (p <= 0.05). Sonuç: Sonuç olarak, spor okulu öğrencilerinin, sigara kullanımının zararlı etkileri konusundaki farkındalıklarını arttırmak ve halkın yoğun olarak sigarayı bırakmasını sağlamak için sağlık eğitimi programlarının sağlanmasında aktif rol almaları gerektiğine inanıyoruz.