Miracle-dz/UniFAR-FTUs huggingface dataset:
Theory-based electronic learning intervention to support appropriate antibiotic prescribing by nurses and pharmacists: intervention development and feasibility study protocol

Introduction Nurse and pharmacist independent prescribers manage patients with respiratory tract infections and are responsible for around 8% of all primary care antibiotic prescriptions. A range of factors influence the prescribing behaviour of these professionals, however, there are no interventions available specifically to support appropriate antibiotic prescribing behaviour by these groups. The aims of this paper are to describe (1) the development of an intervention to support appropriate antibiotic prescribing by nurse and pharmacist independent prescribers and (2) an acceptability and feasibility study designed to test its implementation with these prescribers. Method and analysis Development of intervention: a three-stage, eight-step method was used to identify relevant determinants of behaviour change and intervention components based on the Behaviour Change Wheel. The intervention is an online resource comprising underpinning knowledge and an interactive animation with a variety of open and closed questions to assess understanding. Acceptability and feasibility of intervention: nurse and pharmacist prescribers (n=12–15) will use the intervention. Evaluation includes semi-structured interviews to capture information about how the user reacts to the design, delivery and content of the intervention and influences on understanding and engagement, and a pre-post survey to assess participants’ perceptions of the impact of the intervention on knowledge, confidence and usefulness in terms of application to practice. Taking an initial inductive approach, data from interview transcripts will be coded and then analysed to derive themes. These themes will then be deductively mapped to the Capability, Opportunity, Motivation-Behaviour model. Descriptive statistics will be used to analyse the survey data, and trends identified. Ethics and dissemination Ethical approval for the study has been provided by the School of Healthcare Sciences Research Governance and Ethics Committee, Cardiff University. The findings will be disseminated via publication in peer-reviewed journals and through conference presentations.
Postoperative hyperglycemia may negatively impact cytomegalovirus infection in seropositive liver transplant recipients: a retrospective cohort study

The aim of the study was to evaluate the association between postoperative hyperglycemia and CMV infection. We analyzed 741 CMV seropositive recipients, of livers from seropositive living donors, who underwent preemptive CMV treatment without CMV prophylaxis. The primary outcome was early CMV infection within 1 month after surgery. Hyperglycemia was defined when mean postoperative blood glucose concentration was >180 mg/dl based on previous research and guidelines. Survival analysis was performed using the Fine and Gray model by accounting for the competing risk of CMV infection‐unrelated death. Of the 741 recipients (hyperglycemic group, n = 287; nonhyperglycemic group, n = 454), 372 (50.2%) recipients developed cytomegalovirus (CMV) infection within 1 month after surgery. CMV infection risk was significantly higher in hyperglycemic group than in nonhyperglycemic group in univariable analysis [hazard ratio (HR) 1.34, 95% confidence interval (CI), 1.08–1.66; P = 0.007] and in multivariable analysis (HR 1.25, 95% CI 1.0–1.54; P = 0.038). CMV infection risk was also significantly associated with recipient age, graft ischemia time, model for end‐stage liver disease score, and preoperative neutrophil‐to‐lymphocyte ratio (P < 0.05). In conclusion, preventing postoperative hyperglycemia appears to be an important factor decreasing the risk of CMV infection in seropositive liver transplant recipients undergoing preemptive CMV treatment.
Green Bio-Assisted Synthesis, Characterization and Biological Evaluation of Biocompatible ZnO NPs Synthesized from Different Tissues of Milk Thistle (Silybum marianum)

The purpose of the current study was green synthesis of ZnO-nanoparticles (NPs) from different tissues of Silybum marianum (L.) Gaernt. (i.e., seeds, wild plant, in vitro derived plantlets and callus cultures) followed by extensive characterization and evaluation of their biological potency. ZnO-NPs thus synthesized were subjected to characterization using standard techniques such as XRD, FTIR and SEM. Thermal stability of synthesized NPs was also evaluated using thermo-gravimetric analysis. Highly stable crystalline NPs with size ranging between 30.8 and 46.0 nm were obtained from different tissues of S. marianum. These NPs have revealed a wide range of biological applications showing antioxidant, moderate α-amylase inhibitor, antibacterial and cytotoxic potencies. The highest antibacterial activity (20 ± 0.98 mm) was shown by seed extract-mediated ZnO NPs against Staphylococcus aureus (ATCC-6538). Seed extract-mediated ZnO NPs also showed the most potent antioxidant activity (27.7 ± 0.9 µgAAE/mg, 23.8 ± 0.7 µgAAE/mg and 12.7 ± 1.9% total antioxidant capacity (TAC), total reducing power (TRP) and DPPH-free radical scavenging assay (FRSA), respectively). All of the synthesized ZnO NPs also showed cytotoxic activity against the hepato-cellular carcinoma (HepG2) human cells. Interestingly, these ZnO NPs were also highly biocompatible, as evidenced by the brine shrimp lethality and human red blood cells hemolytic assays. Among all of the NPs synthesized and used, the effect of seed extract-mediated NPs was found to be most promising for future applications.
Comparison of Active Electrode Materials for Non-Contact ECG Measurement

For long-term and more convenience electrocardiograph (ECG) monitoring, an active- electrode-based ECG monitoring system, which can measure ECG through clothes, is proposed in this paper. The hardware of the system includes active electrodes, signal processing and data transmission modules and the software mainly includes a denoising algorithm based on empirical mode decomposition (EMD). Then the proposed system was verified using the comparison of the ECG signals measured synchronously by active electrodes and Ag/AgCl electrodes. In addition, three flexible materials, including conductive textile, copper foil tape and a flexible printed circuit (FPC) are developed for the sensing layer with active electrodes. To compare the performance of these three materials for the sensing layer, the ECG signals of 10 subjects were measured by different materials in three postures and several indexes for quality evaluation were calculated. Results show that effective and clear ECG waveforms can be measured by all three kinds of materials and the quality of ECG signals measured by FPC is the best by conducting a significant t-test for signal quality indexes of three materials.
Scopularides Revisited: Molecular Networking Guided Exploration of Lipodepsipeptides in Australian Marine Fish Gastrointestinal Tract-Derived Fungi

Chemical analysis of a cultivation of an Australian Mugil mullet gastrointestinal tract (GIT) derived fungus, Scopulariopsis sp. CMB-F458, yielded the known lipodepsipeptides scopularides A (1) and B (2). A comparative global natural product social (GNPS) molecular networking analysis of ×63 co-isolated fungi, detected two additional fungi producing new scopularides, with Beauveria sp. CMB-F585 yielding scopularides C–G (3–7) and Scopulariopsis sp. CMB-F115 yielding scopularide H (8). Structures inclusive of absolute configurations were assigned by detailed spectroscopic and C3 Marfey’s analysis, together with X-ray analyses of 3 and 8, and biosynthetic considerations. Scopularides A–H (1–8) did not exhibit significant growth inhibitory activity against a selection of Gram positive (+ve) and negative (−ve) bacteria, a fungus, or a panel of three human carcinoma cell lines.
Brentuximab vedotin in relapsed or refractory classical hodgkin lymphoma: real life experience in Norway 2011–2016

Alexander Fosså, Knut Smeland, Unn-Merete Fagerli, Renate B. Galleberg, Hanne S. Bersvendsen and Harald Holte Department of Oncology, Oslo University Hospital, Oslo, Norway; KG Jebsen Centre for B-Cell Malignancies, University of Oslo, Oslo, Norway; Department of Oncology, St. Olav’s Hospital, Trondheim, Norway; Department of Oncology and Medical Physics, Haukeland University Hospital, Bergen, Norway; Department of Oncology, University Hospital of Northern Norway, Tromsø, Norway
RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase–mediated centrosomal cohesion and ciliogenesis deficits

Abstract Mutations in the LRRK2 kinase are the most common cause of familial Parkinson’s disease, and variants increase risk for the sporadic form of the disease. LRRK2 phosphorylates multiple RAB GTPases including RAB8A and RAB10. Phosphorylated RAB10 is recruited to centrosome-localized RILPL1, which may interfere with ciliogenesis in a disease-relevant context. Our previous studies indicate that the centrosomal accumulation of phosphorylated RAB8A causes centrosomal cohesion deficits in dividing cells, including in peripheral patient-derived cells. Here, we show that both RAB8 and RAB10 contribute to the centrosomal cohesion deficits. Pathogenic LRRK2 causes the centrosomal accumulation not only of phosho-RAB8 but also of phospho-RAB10, and the effects on centrosomal cohesion are dependent on RAB8, RAB10 and RILPL1. Conversely, the pathogenic LRRK2-mediated ciliogenesis defects correlate with the centrosomal accumulation of both phospho-RAB8 and phospho-RAB10. LRRK2-mediated centrosomal cohesion and ciliogenesis alterations are observed in patient-derived peripheral cells, as well as in primary astrocytes from mutant LRRK2 mice, and are reverted upon LRRK2 kinase inhibition. These data suggest that the LRRK2-mediated centrosomal cohesion and ciliogenesis defects are distinct cellular readouts of the same underlying phospho-RAB8/RAB10/RILPL1 nexus and highlight the possibility that either centrosomal cohesion and/or ciliogenesis alterations may serve as cellular biomarkers for LRRK2-related PD.
The effect of volunteers’ care and support on the health outcomes of older adults in acute care: A systematic scoping review

Abstract Aim To examine the available evidence on the effects of care and support provided by volunteers on the health outcomes of older adults in acute care services. Background Acute hospital inpatient populations are becoming older, and this presents the potential for poorer health outcomes. Factors such as chronic health conditions, polypharmacy and cognitive and functional decline are associated with increased risk of health care‐related harm, such as falls, delirium and poor nutrition. To minimise the risk of health care‐related harm, volunteer programmes to support patient care have been established in many hospitals worldwide. Design A systematic scoping review. Methods The review followed the PRISMA Extension for Scoping Reviews (PRISMA‐ScR) (File S1). Nine databases were searched (CINAHL, MEDLINE, EMBASE, Cochrane, Scopus, Web of Science, PubMed, ScienceDirect and JBI) using the following key terms: ‘hospital’, ‘volunteer’, ‘sitter’, ‘acute care’, ‘older adults’, ‘confusion’, ‘dementia’ and ‘frail’. The search was limited to papers written in English and published from 2002–2017. Inclusion criteria were studies involving the use of hospital volunteers in the care or support of older adult patients aged ≥ 65 years, or ≥ 50 years for Indigenous peoples, with chronic health conditions, cognitive impairment and/or physical decline or frailty, within the acute inpatient settings. Results Of the 199 articles identified, 17 articles that met the inclusion criteria were critically appraised for quality, and 12 articles were included in the final review. Conclusions There is evidence that the provision of volunteer care and support with eating and drinking, mobilising and therapeutic activities can impact positively upon patient health outcomes related to nutrition, falls and delirium. Further robust research is needed to determine the impact of volunteers in acute care and the specific care activities that can contribute to the best outcomes for older adults. Relevance to clinical practice Volunteers can play a valuable role in supporting care delivery by nurses and other health professionals in acute care services, and their contribution can improve health outcomes for older adults in this setting.
Laser Shocking Induced Nanoscale Kink-Bands in WSe2 2D Crystals.

The response of materials to high stress and strain rate has been a long-term scientific interest in nature. The formation of kinks is a common deformation feature under high pressure and strain rates among foliated structures, such as rock-forming minerals. Although deformation of foliated rock layers in the geology has been investigated for a century, the deformation behavior of their nanoscale counterparts, e.g. two-dimensional (2D) layered materials under high stress and strain rate has not been investigated. 2D transition metal dichalcogenides (TMD) have very strong in-plane rigidity, while the interlayer shear modulus is three orders of magnitude lower than their in-plane Young's modulus. Here, we study the structure and property changes in multilayer WSe2 2D layers during a 3D nanoshaping process where laser shock pressure of GPa-level is applied to imprint the 2D multilayers into a designed nanomold, forming large local bending strain of 5~6%. The microstructure of the 2D multilayers after laser shocking is observed to be a nanoscale kink-band, similar to that of strained geological layered crystals, due to the high pressure induced bending and shearing. The deformed kink-band structure is investigated experimentally by high-resolution transmission electron microscopy (TEM) and atomic force microscope (AFM) and validated by molecular dynamics (MD) simulations. The changes in the resulting electronic band structure are investigated by first principle calculations. The laser shock straining technology to induce kink-bands structure can enrich the understanding and facilitate the applications of many 2D materials.
Topographical Visualization of the Reciprocal Projection between the Medial Septum and the Hippocampus in the 5XFAD Mouse Model of Alzheimer’s Disease

It is widely known that the degeneration of neural circuits is prominent in the brains of Alzheimer’s disease (AD) patients. The reciprocal connectivity of the medial septum (MS) and hippocampus, which constitutes the septo-hippocampo-septal (SHS) loop, is known to be associated with learning and memory. Despite the importance of the reciprocal projections between the MS and hippocampus in AD, the alteration of bidirectional connectivity between two structures has not yet been investigated at the mesoscale level. In this study, we adopted AD animal model, five familial AD mutations (5XFAD) mice, and anterograde and retrograde tracers, BDA and DiI, respectively, to visualize the pathology-related changes in topographical connectivity of the SHS loop in the 5XFAD brain. By comparing 4.5-month-old and 14-month-old 5XFAD mice, we successfully identified key circuit components of the SHS loop altered in 5XFAD brains. Remarkably, the SHS loop began to degenerate in 4.5-month-old 5XFAD mice before the onset of neuronal loss. The impairment of connectivity between the MS and hippocampus was accelerated in 14-month-old 5XFAD mice. These results demonstrate, for the first time, topographical evidence for the degradation of the interconnection between the MS and hippocampus at the mesoscale level in a mouse model of AD. Our results provide structural and functional insights into the interconnectivity of the MS and hippocampus, which will inform the use and development of various therapeutic approaches that target neural circuits for the treatment of AD.
Respiratory symptoms and lung functional impairments associated with occupational exposure to poultry house pollutants

This study aimed to assess respiratory symptoms and the pulmonary function test (PFT) in a group of poultry workers. The prevalence of respiratory symptoms was determined. Airborne concentrations of total and repairable dusts exceeded the threshold limit values. Gram-positive cocci and Cladosporium were the dominant genera of bacteria and fungi, respectively. The prevalence of respiratory symptoms was significantly higher in the exposed subjects. Mean baseline values of forced expiratory volume (FEV1), FEV1 to forced vital capacity (FVC) ratio (FEV1/FVC) and peak expiratory flow (PEF) were significantly lower in the exposed group. Significant cross-shift decrements were noted in vital capacity (VC), FVC, FEV1, PEF and FEV1/FVC of the exposed subjects. A dominant pattern of lung function abnormality was found to be obstructive. Exposure to poultry pollutants may result in a significant increase in the prevalence of respiratory symptoms as well as both acute reversible and chronic irreversible decrements in the PFT.
Unified Multi-View Orthonormal Non-Negative Graph Based Clustering Framework

—Spectral clustering is an effective methodology for unsupervised learning. Most traditional spectral clustering algorithms involve a separate two-step procedure and apply the transformed new representations for the ﬁnal clustering results. Recently, much progress has been made to utilize the non- negative feature property in real-world data and to jointly learn the representation and clustering results. However, to our knowledge, no previous work considers a uniﬁed model that incorporates the important multi-view information with those properties, which severely limits the performance of existing methods. Inthis paper, we formulate a novel clustering model, which exploits the non-negative feature property and, more importantly, incorporates the multi-view information into a uniﬁed joint learning framework: the uniﬁed multi-view orthonormal non-negative graph based clustering framework (Umv-ONGC). Then, we derive an effective three-stage iterative solution for the proposed model and provide analytic solutions for the three sub-problems from the three stages. We also explore, for the ﬁrst time, the multi-model non-negative graph-based approach to clustering data based on deep features. Extensive experiments on three benchmark data sets demonstrate the effectiveness of the proposed method.
The Phylum Bryozoa as a Promising Source of Anticancer Drugs

Recent advances in sampling and novel techniques in drug synthesis and isolation have promoted the discovery of anticancer agents from marine organisms to combat this major threat to public health worldwide. Bryozoans, which are filter-feeding, aquatic invertebrates often characterized by a calcified skeleton, are an excellent source of pharmacologically interesting compounds including well-known chemical classes such as alkaloids and polyketides. This review covers the literature for secondary metabolites isolated from marine cheilostome and ctenostome bryozoans that have shown potential as cancer drugs. Moreover, we highlight examples such as bryostatins, the most known class of marine-derived compounds from this animal phylum, which are advancing through anticancer clinical trials due to their low toxicity and antineoplastic activity. The bryozoan antitumor compounds discovered until now show a wide range of chemical diversity and biological activities. Therefore, more research focusing on the isolation of secondary metabolites with potential anticancer properties from bryozoans and other overlooked taxa covering wider geographic areas is needed for an efficient bioprospecting of natural products.
Theoretical Prediction of Mechanical Strength and Desalination Performance of One-Atom-Thick Hydrocarbon Polymer in Pressure-Driven Separation

One-atom-thick materials hold promise for the future of membrane-based gas purification and water filtration applications. However, there are a few investigations on the mechanical properties of these materials under pressure-driven condition. Here, by employing molecular simulation techniques and continuum mechanics simulation, we investigate the mechanical strength of two-dimensional hydrocarbon polymers containing sub-nanometer pores with various topologies. We demonstrate that the mechanical strengths of the membranes are correlated with their pore sizes and geometries. In addition, when the pore size of substrates is controlled within a reasonable range, all of the membrane candidates can withstand the practical hydraulic pressure of few megapascal. The studied materials also exhibit better seawater desalination performance as compared to the traditional polymeric reverse osmosis membrane. This work presents a new route to design new separation membrane, and also propose a simulation method to evaluate the mechanical strength and desalination performance.
Cut and break verbs in Sranan

Abstract Guerssel et al. (1985) propose that crosslinguistically, separation verbs group into cut verbs and break verbs based on their meaning. This meaning supposedly affects the constructions in which the verbs occur, e.g., only break verbs are expected to participate in the causative/inchoative alternation. In Sranan, a verb that superficially looks like ‘cut’ in English is actually a break verb. Also, not only break verbs participate in the causative/inchoative alternation, as expected, but cut verbs do also. I argue that the intransitive use of cut verbs does not yield a passive construction as proposed by some; instead, it is inchoative.
Direct and Indirect Cost of Obesity Among the Privately Insured in the United States: A Focus on the Impact by Type of Industry.

OBJECTIVE To evaluate obesity-related costs and body mass index (BMI) as a cost predictor among privately insured employees by industry. METHODS Individuals with/without obesity were identified using the Optum Health Reporting and Insights employer claims database (1/2010-3/2017). Direct/indirect costs were reported per-patient-per-year (PPPY). Multivariate models were used to estimate the association between obesity and high costs (≥80th percentile) by industry. RESULTS Overall (N = 86,221), direct and absenteeism/disability cost differences between class I obesity (BMI 30.0-34.9) and reference were $1,775 and $617 PPPY, respectively (P < 0.05). Among employees with obesity (BMI≥30), highest total costs were observed in the government/education/religious services, food/entertainment services, and technology industries. Class I obesity increased the odds of high costs (≥80th percentile) within each industry (odds ratios vs reference = 1.09-5.17). CONCLUSIONS Obesity (BMI≥30) was associated with high costs among employees of major US industries.