Miracle-dz/UniFAR-FTUs huggingface dataset:
“Maybe a Long Fast Is Good for You”: Health Conceptualisations in YouTube Diet Videos

In this paper, we study which health conceptualisations are promoted or supported by intermittent fasting, no-carb-no-sugar, and endomorph Diet YouTubers and how they relate to existing definitions of health. In order to openly understand how YouTubers present health concepts, we will study health conceptualisations in YouTube diet videos qualitatively, through the use of thematic analysis. We identify five main themes: weight management, prior dietary awareness, diet literacy, quality of life, and the satisfaction of functional needs. We find that YouTubers substitute the WHO’s pursuit of a complete state of well-being by an implicit, tacit version of new health concepts. The tacit form allows them to stay practical and to focus on real-world dietary concerns, such as answers to the simple question “what should I eat to stay healthy? ”. Diet YouTubers do not, however, neatly position themselves within existing health conceptualisations and they offer views on health that move beyond “formal” conceptualisations, including self-inspection, timing, preparation and planning and context-design. Differing from the universal definitions of health, the Diet YouTubers we studied target specific audiences with their presentations of healthy eating.
Beauty and Wellness in the Semantic Memory of the Beholder

Beauty and wellness are terms used often in common parlance, however their meaning and relation to each other is unclear. To probe their meaning, we applied network science methods to estimate and compare the semantic networks associated with beauty and wellness in different age generation cohorts (Generation Z, Millennials, Generation X, and Baby Boomers) and in women and men. These mappings were achieved by estimating group-based semantic networks from free association responses to a list of 47 words, either related to Beauty, Wellness, or Beauty + Wellness. Beauty was consistently related to Elegance, Feminine, Gorgeous, Lovely, Sexy, and Stylish. Wellness was consistently related Aerobics, Fitness, Health, Holistic, Lifestyle, Medical, Nutrition, and Thrive. In addition, older cohorts had semantic networks that were less connected and more segregated from each other. Finally, we found that women compared to men had more segregated and organized concepts of Beauty and Wellness. In contemporary societies that are pre-occupied by the pursuit of beauty and a healthy lifestyle, our findings shed novel light on how people think about beauty and wellness and how they are related across different age generations and by sex.
Disentangling the Possible Drivers of Indri indri Microbiome: A Threatened Lemur Species of Madagascar

Research on the gut microbiome may help with increasing our understanding of primate health with species’ ecology, evolution, and behavior. In particular, microbiome-related information has the potential to clarify ecology issues, providing knowledge in support of wild primates conservation and their associated habitats. Indri (Indri indri) is the largest extant living lemur of Madagascar. This species is classified as “critically endangered” by the IUCN Red List of Threatened Species, representing one of the world’s 25 most endangered primates. Indris diet is mainly folivorous, but these primates frequently and voluntarily engage in geophagy. Indris have never been successfully bred under human care, suggesting that some behavioral and/or ecological factors are still not considered from the ex situ conservation protocols. Here, we explored gut microbiome composition of 18 indris belonging to 5 different family groups. The most represented phyla were Proteobacteria 40.1 ± 9.5%, Bacteroidetes 28.7 ± 2.8%, Synergistetes 16.7 ± 4.5%, and Firmicutes 11.1 ± 1.9%. Further, our results revealed that bacterial alpha and beta diversity were influenced by indri family group and sex. In addition, we investigated the chemical composition of geophagic soil to explore the possible ecological value of soil as a nutrient supply. The quite acidic pH and high levels of secondary oxide-hydroxides of the soils could play a role in the folivorous diet’s gut detoxification activity. In addition, the high contents of iron and manganese found the soils could act as micronutrients in the indris’ diet. Nevertheless, the concentration of a few elements (i.e., calcium, sulfur, boron, nickel, sodium, and chromium) was higher in non-geophagic than in geophagic soils. In conclusion, the data presented herein provide a baseline for outlining some possible drivers responsible for the gut microbiome diversity in indris, thus laying the foundations for developing further strategies involved in indris’ conservation.
Terrain-Based Shadow Correction Method for Assessing Supraglacial Features on the Greenland Ice Sheet

The presence of shadows in remotely sensed images can reduce the accuracy of land surface classifications. Commonly used methods for removing shadows often use multi-spectral image analysis techniques that perform poorly for dark objects, complex geometric models, or shaded relief methods that do not account for shadows cast on adjacent terrain. Here we present a new method of removing topographic shadows using readily available GIS software. The method corrects for cast shadows, reduces the amount of over-correction, and can be performed on imagery of any spectral resolution. We demonstrate this method using imagery collected with an uncrewed aerial vehicle (UAV) over a supraglacial stream catchment in southwest Greenland. The structure-from-motion digital elevation model showed highly variable topography resulting in substantial shadowing and variable reflectance values for similar surface types. The distribution of bare ice, sediment, and water within the catchment was determined using a supervised classification scheme applied to the corrected and original UAV images. The correction resulted in an insignificant change in overall classification accuracy, however, visual inspection showed that the corrected classification more closely followed the expected distribution of classes indicating that shadow correction can aid in identification of glaciological features hidden within shadowed regions. Shadow correction also caused a substantial decrease in the areal coverage of dark sediment. Sediment cover was highly dependent on the degree of shadow correction (k coefficient), yet, for a correction coefficient optimized to maximize shadow brightness without over-exposing illuminated surfaces, terrain correction resulted in a 49% decrease in the area covered by sediment and a 29% increase in the area covered by water. Shadow correction therefore reduces the overestimation of the dark surface coverage due to shadowing and is a useful tool for investigating supraglacial processes and land cover change over a wide variety of complex terrain.
Drivers of Millet Consumption Among School Aged Children in Central Tanzania

Background: Iron and zinc deficiency are common public health problems in low-income countries largely due to poor consumption of iron and zinc rich foods. It has previously been observed that 57% of school aged children (SAC) in Tanzania suffer from anemia. In addition, estimates indicate that over 25% of the population have inadequate zinc intake. Pearl millet is an example of a nutrient dense, resilient cereal crop, that can be promoted to diversify diets and combat iron and zinc deficiency. This study overall aim was to increase pearl millet consumption among school aged (5 – 12 years) children. As part of the study, we investigated, the drivers of food choice relating to pearl millet consumption. Methods: The study was a cross-sectional study of randomly selected households in Kongwa district, Dodoma region of Tanzania. In total, 128 women of reproductive age (20 – 49 years) were randomly selected for the study. A study questionnaire consisting of 66 items, was developed and validated. The constructs in the questionnaire were categorized in two groups: internal and external factors. Respondents were asked to indicate their level of agreement or disagreement with statements read to them by interviewers. The scores on intention and behavior constructs were based on the number of times caregivers intended to, or had fed their school going children with pearl millet in the referent month. Intention was considered high if it was higher than the median intention score of the group, and low if it was equal to or lower than the median scores. Correlations and multiple linear regressions were performed to measure association between constructs and to identify predictive constructs. The Mann-Whitney U test was used for score comparison. Results: There was a significant difference between intention and behavior among those who did not consume pearl millet (P = 0.003), and those who consumed pearl millet two or more times a week, in the same month (P = 0.01). Knowledge was significantly correlated with behavior identity (ρ = 0.58, P = 0.001), while health behavior identity was significantly correlated with intention (ρ = 0.31, P = 0.001). Intention of caregivers was significantly and positively correlated (ρ = 0.44, P = 0.001) with and predicted consumption of pearl millet (ρ = 0.87, P = 0.067). Conclusion: Increasing knowledge or awareness on nutritional benefits of pearl millet among caregivers may increase consumption of pearl millet by children of school going age.
Microbiome Structure and Function in Woodchip Bioreactors for Nitrate Removal in Agricultural Drainage Water

Woodchip bioreactors are increasingly used to remove nitrate (NO3–) from agricultural drainage water in order to protect aquatic ecosystems from excess nitrogen. Nitrate removal in woodchip bioreactors is based on microbial processes, but the microbiomes and their role in bioreactor efficiency are generally poorly characterized. Using metagenomic analyses, we characterized the microbiomes from 3 full-scale bioreactors in Denmark, which had been operating for 4–7 years. The microbiomes were dominated by Proteobacteria and especially the genus Pseudomonas, which is consistent with heterotrophic denitrification as the main pathway of NO3– reduction. This was supported by functional gene analyses, showing the presence of the full suite of denitrification genes from NO3– reductases to nitrous oxide reductases. Genes encoding for dissimilatory NO3– reduction to ammonium were found only in minor proportions. In addition to NO3– reducers, the bioreactors harbored distinct functional groups, such as lignocellulose degrading fungi and bacteria, dissimilatory sulfate reducers and methanogens. Further, all bioreactors harbored genera of heterotrophic iron reducers and anaerobic iron oxidizers (Acidovorax) indicating a potential for iron-mediated denitrification. Ecological indices of species diversity showed high similarity between the bioreactors and between the different positions along the flow path, indicating that the woodchip resource niche was important in shaping the microbiome. This trait may be favorable for the development of common microbiological strategies to increase the NO3– removal from agricultural drainage water.
sCD28, sCD80, sCTLA-4, and sBTLA Are Promising Markers in Diagnostic and Therapeutic Approaches for Aseptic Loosening and Periprosthetic Joint Infection

Aseptic prosthetic loosening and periprosthetic joint infections (PJI) are among the most frequent complications after total knee/hip joint arthroplasty (TJA). Current research efforts focus on understanding the involvement of the immune system in these frequent complications. Different immune cell types have already been implicated in aseptic prosthetic loosening and PJI. The aim of this study was to systematically analyze aspirates from knee and hip joints, evaluating the qualitative and quantitative composition of soluble immunoregulatory markers, with a focus on co-inhibitory and co-stimulatory markers. It has been shown that these molecules play important roles in immune regulation in cancer and chronic infectious diseases, but they have not been investigated in the context of joint replacement. For this purpose, aspirates from control joints (i.e., native joints without implanted prostheses), joints with TJA (no signs of infection or aseptic loosening), joints with aseptic implant failure (AIF; i.e., aseptic loosening), and joints with PJI were collected. Fourteen soluble immunoregulatory markers were assessed using bead-based multiplex assays. In this study, it could be shown that the concentrations of the analyzed immunoregulatory molecules vary between control, TJA, AIF, and PJI joints. Comparing TJA patients to CO patients, sCD80 was significantly elevated. The marker sBTLA was significantly elevated in AIF joints compared to TJA joints. In addition, a significant difference for eight markers could be shown when comparing the AIF and CO groups (sCD27, sCTLA-4, sCD137, sCD80, sCD28, sTIM-3, sPD-1, sBTLA). A significant difference was also reached for nine soluble markers when the PJI and CO groups were compared (sLAG-3, sCTLA-4, sCD27, sCD80, sCD28, sTIM-3, sPD-1, IDO, sBTLA). In summary, the analyzed immunoregulatory markers could be useful for diagnostic purposes as well as to develop new therapeutic approaches for AIF and PJI.
Biochemical and Structural Characterisation of a Novel D-Lyxose Isomerase From the Hyperthermophilic Archaeon Thermofilum sp.

A novel D-lyxose isomerase has been identified within the genome of a hyperthermophilic archaeon belonging to the Thermofilum species. The enzyme has been cloned and over-expressed in Escherichia coli and biochemically characterised. This enzyme differs from other enzymes of this class in that it is highly specific for the substrate D-lyxose, showing less than 2% activity towards mannose and other substrates reported for lyxose isomerases. This is the most thermoactive and thermostable lyxose isomerase reported to date, showing activity above 95°C and retaining 60% of its activity after 60 min incubation at 80°C. This lyxose isomerase is stable in the presence of 50% (v/v) of solvents ethanol, methanol, acetonitrile and DMSO. The crystal structure of the enzyme has been resolved to 1.4–1.7 A. resolution in the ligand-free form and in complexes with both of the slowly reacting sugar substrates mannose and fructose. This thermophilic lyxose isomerase is stabilised by a disulfide bond between the two monomers of the dimeric enzyme and increased hydrophobicity at the dimer interface. These overall properties of high substrate specificity, thermostability and solvent tolerance make this lyxose isomerase enzyme a good candidate for potential industrial applications.
Hyaluronic Acid Is an Effective Dermal Filler for Lip Augmentation: A Meta-Analysis

Introduction: The lips and the mouth play an indispensable role in vocalization, mastication and face aesthetics. Various noxious factors may alter and destruct the original structure, and appearance of the lips and the anatomical area surrounding the mouth. The application of hyaluronic acid (HA) may serve as a safe method for lip regeneration. Although a number of studies exist for HA effectiveness and safety, its beneficial effect is not well-established. Aim: The present meta-analysis and systematic review was performed to investigate the effectiveness of HA on lip augmentation. We also investigated the types and nature of adverse effects (AEs) of HA application. Methods: We reported our meta-analysis in accordance with the PRISMA Statement. PROSPERO protocol registration: CRD42018102899. We performed the systematic literature search in CENTRAL, Embase, and MEDLINE. Randomized controlled trials, cohort studies, case series and case reports were included. The untransformed proportion (random-effects, DerSimonian-Laird method) of responder rate to HA injection was calculated. For treatment related AEs descriptive statistics were used. Results: The systematic literature search yielded 32 eligible records for descriptive statistics and 10 records for quantitative synthesis. The results indicated that the overall estimate of responders (percentage of subjects with increased lip fullness by one point or higher) was 91% (ES = 0.91, 95% CI:0.85−0.96) 2 months after injection. The rate of responders was 74% (ES = 0.74, 95% CI:0.66−0.82) and 46% (ES = 0.46, 95% CI:0.28−0.65) after 6 and 12 months, respectively. We included 1,496 participants for estimating the event rates of AEs. The most frequent treatment-related AEs were tenderness (88.8%), injection site swelling (74.3%) and bruising (39.5%). Rare AEs included foreign body granulomas (0.6%), herpes labialis (0.6%) and angioedema (0.3%). Conclusion: Our meta-analysis revealed that lip augmentation with injectable HA is an efficient method for increasing lip fullness for at least up to 6 months after augmentation. Moreover, we found that most AEs of HA treatment were mild or moderate, but a small number of serious adverse effects were also found. In conclusion, further well-designed RCTs are still needed to make the presently available evidence stronger.
Efficacy and Safety of Chinese Patent Medicine Combined With Oseltamivir in Treatment of Children With Influenza: A meta-Analysis

Background: Recently, Chinese patent medicines (CPMs) have been widely used to treat children with influenza in China, with curative effects. Therefore, the efficacy and safety of such treatment require further evaluation. The present meta-analysis integrated data from several independent studies to determine overall treatment trends in children with influenza. Methods: The following databases were searched for randomized controlled trials (RCTs) published from their inception to December 12, 2020: CNKI, Wanfang, SinoMed, PubMed, Cochrane library, and Embase. Two researchers independently extracted the data, assessed the methodological quality of the studies, and conducted a meta-analysis of the results using Review Manager 5.2. The results were assessed using forest plots, and publication bias was evaluated using a funnel plot. Results: A total of 21 RCTs involving 2960 cases were included. Compared to oseltamivir alone, CPMs combined with oseltamivir reduced the duration of symptoms, including that of fever (mean difference [MD] = −0.64, 95% confidence interval [CI]: −0.86 to −0.41, P < 0.00001), cough (MD = −0.82, 95% CI: −1.02 to −0.62, P < 0.00001), nasal obstruction (MD = −0.88, 95% CI: −1.15 to −0.61, P < 0.00001), and sore throat (MD = −0.92, 95% CI: −1.26 to −0.57, P < 0.00001). Combined therapy also reduced the time of viral shedding (MD = −0.53, 95% CI: −0.70 to −0.36, P < 0.00001) and the occurrence of adverse drug reactions (ADRs) (RR=0.53, 95% CI: 0.34 to 0.83, P = 0.005). Conclusions: CPMs combined with oseltamivir reduced the duration of symptoms, shortened the time of viral shedding, and reduced the number of ADRs. However, these results should be considered with caution because there was marked heterogeneity and publication bias in the research data. More rigorous RCTs should be designed to verify the effect of CPMs in children with influenza.
Physical Activity in the Treatment and Prevention of Heart Failure: An Update

Exercise training and regular physical activity improve peak V̇O2, physical functioning, and quality of life in patients with heart failure, and emerging evidence suggests a role for exercise in heart failure prevention. Abstract Heart failure (HF) is a complex clinical syndrome hallmarked by an inability to match cardiac output with metabolic demand, resulting in exercise intolerance. HF is increasingly prevalent in an aging population and accounts for substantial burden of health care costs and morbidity. Because many of the central and peripheral mechanisms of HF respond favorably to exercise training, its role in HF treatment is becoming established. The role of habitual physical activity in the primary prevention of HF is less clear; however, available evidence is supportive. This article reviews recently published studies on exercise training and usual physical activity in HF treatment and prevention, discusses potential mechanisms, and suggests areas where further research is needed.
RT-qPCR Diagnostics: The “Drosten” SARS-CoV-2 Assay Paradigm

The reverse transcription quantitative polymerase chain reaction (RT-qPCR) is an established tool for the diagnosis of RNA pathogens. Its potential for automation has caused it to be used as a presence/absence diagnostic tool even when RNA quantification is not required. This technology has been pushed to the forefront of public awareness by the COVID-19 pandemic, as its global application has enabled rapid and analytically sensitive mass testing, with the first assays targeting three viral genes published within days of the publication of the SARS-CoV-2 genomic sequence. One of those, targeting the RNA-dependent RNA polymerase gene, has been heavily criticised for supposed scientific flaws at the molecular and methodological level, and this criticism has been extrapolated to doubts about the validity of RT-qPCR for COVID-19 testing in general. We have analysed this assay in detail, and our findings reveal some limitations but also highlight the robustness of the RT-qPCR methodology for SARS-CoV-2 detection. Nevertheless, whilst our data show that some errors can be tolerated, it is always prudent to confirm that the primer and probe sequences complement their intended target, since, when errors do occur, they may result in a reduction in the analytical sensitivity. However, in this case, it is unlikely that a mismatch will result in poor specificity or a significant number of false-positive SARS-CoV-2 diagnoses, especially as this is routinely checked by diagnostic laboratories as part of their quality assurance.
DESIGN AND SYNTHESIS OF COMBINATIONAL CIRCUITS USING REVERSIBLE LOGIC

: Reversible logic has become one of the recent emerging research pursuits contributing to the field of low power dissipating circuit design in the past few years. Reversible logic find its owns applications in various fields which include quantum computing, nanotechnology, digital signal and image processing, optical computing, Low power VLSI etc., Decoders are one of the maximum essential circuit utilized in combinational logic. The whole design of combinational circuits like decoders, comparator, full adder, multiplexer are designed using Fredkin gate, CNOT, Peres gate and R-I gate which give better quantum cost when compared to other Reversible gates. The quantum cost and garbage outputs for combinational circuits in proposed designed has been compared with a previously existing design. The reversible logic circuits are designed and implemented using VHDL code and the simulation results are obtained in Xilinx ISE version 14.7.
Implications of Microfinance for Gender Inequality in Ghana

The paper seeks to investigate whether increased access to microfinance by poor households in Ghana affects intra-household gender inequality and gender asset gap between male-headed households and female-headed households. The paper uses beta regression models and the Oaxaca decomposition to answer this question. The analysis is based on data obtained from household survey conducted in Ghana from May to July 2013. Comparative analysis of households with and without microfinance shows that on average female-headed households receiving micro-credit tend to spend equally on male and female children at the primary and secondary school levels whereas education expenditure is skewed in favor of male children relative to female children in the case of female-headed households without micro-credit. This result translates into higher years of schooling for children in female-headed households with micro-credit compared to their counterparts without micro-credit. On average, females in households receiving micro-credit have a higher share of household assets relative to females in households without micro-credit. The results from this paper suggest that microfinance helps to reduce intra-household gender inequality and gender asset gaps between male-headed and female-headed households.