Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular Biology and Clinical Mitigation of Cancer Treatment-Induced Neuropathy

Disruption of microtubule function is the antitumor mechanism of several classes of drugs used to treat cancer today. However, the significant beneficial effect on tumor outcomes is frequently counterbalanced by neurotoxic complications. Despite an abundance of scientific data, our understanding of the biological mechanisms underlying this toxic reaction remains unclear, further hindering attempts to identify and develop effective preventive strategies. The primary goals of this review are to: (1) provide insight regarding the biology of the microtubule, (2) analyze the molecular and biochemical pathways that may be involved in the development of neurotoxicity, and (3) propose a unifying concept linking drug-induced neuropathy, microtubule dysfunction, and vitamin D.
Current indications for hyperbaric oxygen therapy Lieutenant

medicine had its origins centuries ago, it is only in the last 40 years that good science has existed to support some of its current applications. A lack of soundly constructed scientific research, overenthusiastic reactions to isolated cases, public pressure and financial issues have all contributed to the scepticism which has influenced the acceptance of hyperbaric oxygen therapy into mainstream medicine. This review provides a brief outline of the history, physiological basis, current indications and side effects of hyperbaric oxygen (HBO) therapy.
GARCH effects in another market : Modeling and forecasting kraft prices and conditional volatility

This paper empirically studies price movements and volatility in several Kraft prices by using monthly data. Paper shows that ARMA models with GARCH specifications for the conditional volatility can characterize the prices quite well. The performance of alternative models in terms of in-sample and out-of-sample are investigated by using several statistical loss functions reveal that ARMA models with GARCH effects outperform in predicting future price changes in oneto-twelve months ahead. Out-of-sample forecasting experiments reveal also that ARMA−GARCH models outperform simple AR models and exponential smoothing models in several forecast horizons ranging from one month to six months ahead. In longer terms, including nine and twelve months ahead, GARCH models perform comparable to simple exponential and AR models with varying degree of success depending upon the loss function and ex-post measure of actual volatility used.
W-band Vivaldi antenna in LTCC for CW-radar nearfield distance measurements

A CW-radar sensor concept based on interferometric measurement is presented. The usage of LTCC as sensor substrate offers the possibility to create a highly integrated sensor module, including active and passive components. It is shown, that the antenna integration can be realized by using corrugations and special housing designs for shielding and isolating effects. The used tapered slot antenna with a planar phase front in a small distance related to the wavelength and the high directivity fulfills the requirements for achieving the aspired measurement accuracy of 1 µm or better. Without the usage of calibration algorithms, this accuracy would require a not achievable antenna matching. A calibration approach for eliminating the remaining error signal is shown in this paper.
Mediterranean Conference on Information Systems ( MCIS ) 2012 THE IDENTIFICATION AND DEFINITION OF VALUE MANAGEMENT PRACTICES USED TO DEPLOY IS INVESTMENTS

While many authors focus on the outcome of information systems (IS) investments, this paper explores management practices that support the deployment of IS investments so they can ultimately create value to the organisation. Such practices are defined as value management practices that facilitate the identification, creation, and capture of value in the deployment of IS investments. Very limited academic research has been oriented towards the identification of such value management practices. Moreover, the limited results are fragmented as many scholars investigate one single practice in isolation. Practitioner frameworks emerged in an attempt to integrate multiple value management practices, yet organisations still struggle with getting such practices and frameworks implemented and embedded into their organisations. In an attempt to contribute to the scarce literature, this research has executed a literature review and exploratory case study to identify and clearly define multiple individual value management practices. These findings are structured within the context of a conceptual framework that previously has been employed by IS scholars. As a result, the practices are categorised into structures, processes, and relational mechanisms and together constitute a new value management framework. In addition, this framework portrays the organisational level on which each value management practice can be operational, i.e. at individual IS investment level, portfolio level or enterprise level. By doing so, the value management framework creates a clear vision on the coherence and interrelationship of value management practices which might help organisations in the deployment and value creation of IS investments.
Expression of Xenopus suppressor of cytokine signaling 3 (xSOCS3) is induced by epithelial wounding

The suppressor of cytokine signaling (SOCS) family of proteins are intracellular mediators of cytokine signaling. These proteins are induced rapidly by cytokine stimulation and act in a classic negative‐feedback loop to attenuate the cellular response to the cytokine signal. In this study, we present the cloning and initial characterization of the Xenopus SOCS3 gene. We show that xSOCS3 is rapidly induced in response to epithelial wounding in the tadpole. The induction of xSOCS3 in response to trauma is transient with maximal expression being reached 1 hr after the injury and diminishing after that. Unlike other genes known to be responsive to wound‐induced activation of the mitogen‐activated protein (MAP) kinase pathway, such as Egr1, SOCS3 expression in response to trauma is unaffected by blockade of the MAP kinase pathway by chemical inhibitors. Developmental Dynamics 233:1123–1130, 2005. © 2005 Wiley‐Liss, Inc.
Regional CNS Levels of Acetylcholine and Choline During Hypoglycemic Stupor and Recovery

During insulin stupor in mice, acetylcholine levels in cerebral cortex, cerebellum. brainstem, striatum, and hippocampus were unchanged from control values despite brain glucose concentrations 3‐10% of normal, whereas choline levels rose 2.4‐3.6‐fold in all five CNS regions. Brain acetylcholine and choline levels did not change during recovery following glucose injection. The data suggest that. in hypoglycemic stupor, (1) overall rates of acetylcholine synthesis and degradation remain balanced within each of the CNS regions studied: (2) the biochemical mechanism that elevates brain choline levels is unlikely to be related only to cholinergic synaptic processes: and (3) brain choline levels need not rise for stupor to occur.
Health-Promoting Self-Care in Family Caregivers

Caregiving for family members with cognitive impairment is stressful and time consuming. Because of the attention needed to manage the memory and behavior problems of the care receiver, family caregivers have little time to attend to their own health needs. Most research related to the health of family caregivers has been conducted within a stress-illness framework. Fewer researchers have studied caregiver health from a health-promotion paradigm. The purpose of this study was to compare health-promoting self-care behavior in family caregivers with demographically matched noncaregivers and to investigate the mediational effect of health-promoting self-care behavior on the relationship between stress and well-being. Findings revealed that family caregivers scored significantly lower on all measures of health promotion, with the exception of Nutrition and Number of Medications, and significantly higher on Barriers to Health-Promoting Actions. Health-promoting self-care behavior acted as a mediator to reduce the effect of caregiver stress on general well-being.
Analysis of Cloud Business Models for the Industrial B 2 B Market

Cloud technology is by today common in consumer targeted IT markets. In industrial B2B markets however, cloud technology may provide added value for the customers, but these markets behave more traditional and conservative compared to B2C markets and are therefore slower in adapting the new technology. This highlights the need for the development of appropriate business models accompanying the introduction of cloud technology to industrial B2B markets. This industrial study introduces a new framework for the analysis of cloud business models and examines three B2B cloud business models from a broad range of industries. It was found first that cloud technology may be very suitable for B2B businesses, as it poses the opportunity to address multiple roles within a customer organization at once but with different offerings. Secondly, the examined cloud business models did not replace existing offerings in the respective market, but introduced new added value for the customer. Third, the majority of the B2B cloud offerings could also be solved with a serviceclient architecture, but that a ”cloud” label can support marketing related efforts. This study builds the basis for deriving common patterns from B2B cloud business models, which may in the future enable the efficient development of B2B specific business models for industrial cloud offerings.
Propagule Pressure and Introduction Pathways of Bromus tectorum (Cheatgrass; Poaceae) in the Central United States

An introduced species’ propagule pressure strongly influences the genetic diversity and evolutionary potential of its descendants and even the likelihood of biological invasion. We examined population genetic consequences arising from introduction of the invasive annual grass Bromus tectorum into the central United States (U.S.). The origin and frequency of introductions were investigated by assembling allozyme diversity data from 60 widely spaced populations. At least five introduction events contributed to the grass’s genetic diversity in the central U.S. Populations in this region have fewer alleles (30 vs. 43) and polymorphic loci (5 vs. 13) than native populations, evidence of a genetic bottleneck. However, the populations are, on average, more genetically diverse and less structured than native populations. Assembly within central U.S. populations of previously allopatric genotypes may have allowed the formation, via outcrossing, of a rare multilocus genotype. Genetic admixtures may have occurred through any combination of east-to-west spread coincident with nineteenth-century arrival of European settlers, dispersal from southern Ontario via Great Lakes shipping and commerce, and direct introduction from the native range. Our results illustrate the population genetic consequences of relatively high propagule pressure (i.e., repeated immigrations to a new range from multiple sources).
Proteomic identification of molecular targets of gambogic acid: Role of stathmin in hepatocellular carcinoma

Gamboge has been developed as an injectable drug for cancer treatment in China. In this study, the inhibition ratio and their IC50 values of two derivatives from Gamboge in hepatocellular carcinoma (HCC) were determined. Proteomic approach was employed to reveal the target proteins of these two derivatives, gambogic acid (GA), and gambogenic acid (GEA). HCC cells were cultured under varied conditions with the addition of either GA or GEA. Twenty differentially expressed proteins were identified and the four most distinctly expressed proteins were further validated by Western blotting. GA and GEA revealed inhibitory effects on HCC cell proliferation. The expression of cyclin‐dependent kinase 4 inhibitor A and guanine nucleotide‐binding protein β subunit 1 were upregulated by both xanthones, whilst the expression of 14‐3‐3 protein sigma and stathmin 1 (STMN1) were downregulated. Furthermore, overexpression of STMN1 in HCC cells decreased their sensitivity, whilst small interfering RNAs targeting STMN1 enhanced their sensitivity to GA and GEA. In conclusion, our study suggested for the first time that STMN1 might be a major target for GA and GEA in combating HCC. Further investigation may lead to a new generation of anticancer drugs exerting synergistic effect with conventional therapy, thus to promote treatment efficacy.
Polycomb repression of flowering during early plant development

All plants flower late in their life cycle. For example, in Arabidopsis, the shoot undergoes a transition and produces reproductive flowers after the adult phase of vegetative growth. Much is known about genetic and environmental processes that control flowering time in mature plants. However, little is understood about the mechanisms that prevent plants from flowering much earlier during embryo and seedling development. Arabidopsis embryonic flower (emf1 and emf2) mutants flower soon after germination, suggesting that a floral repression mechanism is established in wild-type plants that prevents flowering until maturity. Here, we show that polycomb group proteins play a central role in repressing flowering early in the plant life cycle. We found that mutations in the Fertilization Independent Endosperm (FIE) polycomb gene caused the seedling shoot to produce flower-like structures and organs. Flower-like structures were also generated from the hypocotyl and root, organs not associated with reproduction. Expression of floral induction and homeotic genes was derepressed in mutant embryos and seedlings. These results suggest that FIE-mediated polycomb complexes are an essential component of a floral repression mechanism established early during plant development.
Functional morphology of the testis.

graded series of ethanol, cleared in propylene oxide and embedded in Epon. Onesections were cut with glass knives, mounted on slides, stained with 1% toluidine blue and examined with the light micro- scope. These sections were used to identify the stages of the cycle of the seminiferous epithelium in the monkey as described by Clermont (1969). Adjacent thin sections, showing silver to pale gold interference colors, were cut with a diamond knife, mounted on uncoated copper grids and stained with lead citrate and uranyl acetate (Reynolds, 1963). The preparations were examined and photographed on a Philips 200 or JEM 100 S electron microscope. The techniques utilizing intercellular tracer compounds such as lan- thanum nitrate and horseradish peroxidase have been described previously (Dym and Fawcett, 1970; Dym,
Reverberant Neural Network in Optical Technology

In this paper the authors present a reverberant neural network achieved into optical technology that stores binary information. The reverberant neural networks have a very important role into memorizing processes especially into short time memory. Although they achieve a short time memorizing the reverberant neural networks are used for writing of information into long time memory. The reverberant presented can be a variant by volatile memory for neural computers. The reverberant network can be used for neural computers and as buffer memory for writing process into permanent memories because of its high speeds by processing The model presented by authors has many advantages such as: the high processing speed, possibility by implementation not only into integrated optic but also into classical optic, immunity to electromagnetic fields, cheap etc
Growth Factors, Cytokines, Cell Cycle Molecules Accelerated Wound Closure in Mice Deficient for Interleukin-10

The impact of the local inflammatory response on the process of wound healing has been debated for de-cades. In particular, the question whether infiltrating macrophages and granulocytes promote or impede tissue repair has received much attention. In the present study, we show that wound healing is accelerated in mice deficient for the anti-inflammatory cytokine interleukin (IL)-10. IL-10 (cid:1) / (cid:1) mice closed excisional wounds significantly earlier compared with IL-10-competent control littermates. This effect was attributable to accelerated epithelialization as well as enhanced contraction of the wound tissue in the mutant animals. Increased (cid:2) -smooth muscle actin expression in IL-10-deficient mice suggests that augmented myofibroblast differentiation is responsible for the enhanced contraction of wounds in mutant mice. The number of macrophages infiltrating the wound tissue was significantly increased in IL-10 (cid:1) / (cid:1) mice compared with control littermates suggesting that this cell type mediates the accelerated tissue repair. These results show for the first time that IL-10 can impede wound repair. (Am J Pathol 2007, 170:188–202; a role in tissue repair. strong expression of two newly identified markers of alternatively activated macrophages, Fizz1 and Ym1, 21,22 by a fraction of macrophages in wounds of control and IL-10-deficient mice. our knowledge, this is the first description of alternatively activated macrophages in skin wounds. IL-10 the production of IFN- and TNF- (cid:1) key mediators classical macrophage activation, IL-10 (cid:1) / (cid:1) injury. Our results indicate that IL-10 is not to induce or maintain the alternatively activated macrophage phenotype. Current studies in our group investigate the impact of IL-10 deficiency on macrophage activation pathways.
Molecular dynamics simulations of heat conduction in multi-walled carbon nanotubes

Heat conduction in multi-walled carbon nanotubes (MWNTs) was studied using non-equilibrium molecular dynamics simulations. This research focuses on the effects of the multi-wall structure of the MWNTs on the heat conduction. The results show that the thermal conductivity of a MWNT is almost the same as that of the corresponding single-walled carbon nanotubes (SWNTs) rather than much smaller as has been suggested. Thus, the multi-wall structure does not significantly affect the thermal conduction in the MWNTs. Analysis of the temperature profiles and the phonon density of states confirms that there is almost no heat transport between the MWNT layers and that each layer conducts heat nearly independently along parallel channels. This is physically reasonable since the weak inter-wall interactions and large interfacial thermal resistances make the MWNT layers behave like parallel thermal circuits.
Parallel compiling techniques

Currently, the software technology is not keeping up with the hardware technology. New software must be planned to take advantage of new hardware innovations. This paper describes one such effort. Techniques are described for carrying out the compilation process on a global highly-parallel computer. The problem of data structures and organization within the parallel computer is considered, and two organizations, called the horizontal and the vertical data organizations, are investigated.
Citygen: An Interactive System for Procedural City Generation

Contemporary 3D games are often situated within large urban environments. This necessitates a time-consuming and expensive content creation process involving the modelling of vast amounts of geometric detail: including terrain, roads, buildings, and other associated features. We present a system called Citygen that aims to automate as much of this as possible by employing procedural generation methods to rapidly create the urban geometry typical of a modern city. Procedural methods have long been used within the graphics and game development communities to generate natural phenomena such as plants and trees. We employ these methods to generate the underlying road networks that form the structure of cities and urban neighbourhoods. These road networks are automatically mapped to any supplied terrain model, and adapt themselves to the specific geometry of the underlying terrain. Building footprints are automatically extracted from the resulting model and buildings can then be inserted either procedurally or by hand. Our system is unique in that it is designed to allow developers hands-on interactive control over the generation process. We achieve this by providing an interface allowing the user to directly manipulate geometric elements such as road intersection nodes, and to directly control and specify many aspects of the procedural generation. The results are updated in real time, thus facilitating an interactive design process.
5G Field Trials: OFDM-Based Waveforms and Mixed Numerologies

Service diversity is expected in the upcoming fifth-generation (5G) cellular networks, which poses great challenges to the underlying waveforms to accommodate heterogeneous service requirements in a flexible way. By dividing the bandwidth into several subbands, each having a different numerology, this paper reports a field trial in time division duplex downlink conducted on a configurable test bed in a real-world environment for the performance evaluations of orthogonal frequency-division multiplexing (OFDM)-based 5G waveform candidates, i.e., cyclically prefixed OFDM (CP-OFDM), windowing OFDM (W-OFDM), and filtered OFDM (f-OFDM), in the presence of mixed numerologies. Field trial results confirm the feasibility of mixed numerologies and reveal the impact of several important system parameters, e.g., guard bandwidth, data bandwidth, signal-to-noise ratio (SNR), and transmit power. The results also suggest that f-OFDM outperforms CP-OFDM and W-OFDM in terms of both the spectrum efficiency and robustness in a high SNR regime, and the gain increases with a higher inter-numerology out-of-band interference. In some specific scenarios, ideal spectrum utilization can be realized by f-OFDM which completely removes the guard band.