Miracle-dz/UniFAR-FTUs huggingface dataset:
QUERCETIN REDUCES NUCLEAR NRF2 AND INCREASES NFκB IN BOVINE AORTIC ENDOTHELIAL CELLS CHALLENGED WITH PALMITATE by

Elevated circulating fatty acids can cause oxidative stress and impair endothelial function, leading to cardiovascular disease. Quercetin, a flavonoid in fruits and vegetables, has been found to lower blood pressure in human and animal models, likely through protecting endothelial cell function. The aim of this study was to determine if quercetin protects endothelial cells challenged by a palmitate-induced oxidative state by activating Nrf2, an endogenous regulator of antioxidant defense. We hypothesized that increased Nrf2 activation by quercetin will prevent NFκB activation and result in lower inflammation in palmitate challenged cells. Confluent bovine aortic endothelial cells (BAECs) were treated with 1 μM quercetin and 500 μM palmitic acid either separately or concurrently for five hours. Nrf2 translocation, reactive oxygen species production (ROS), NFκB translocation, and mRNA expression of inflammatory markers were determined. Treatment with quercetin or palmitate alone increased nuclear translocation of Nrf2. However, concurrent treatment with quercetin and palmitate reduced Nrf2 back to control levels. There were no differences in ROS production between any treatment groups. NFκB nuclear translocation was increased with palmitate treatment alone and after co-treatment with palmitate and quercetin. mRNA expression of IL-8 and MCP-1 (markers of inflammation) increased after palmitate and after concurrent treatment with palmitate and quercetin. In conclusion, quercetin reduced nuclear Nrf2 during palmitate
BLM helicase regulates DNA repair by counteracting RAD51 loading at DNA double-strand break sites

homologous recombination (HR) pathway. During HR, BLM has both pro- and anti-recombinogenic activities, either of which may contribute to maintenance of genomic integrity. We find that in cells expressing a mutant ver-sion of BRCA1, an essential HR factor, ablation of BLM rescues genomic integrity and cell survival in the presence of DNA double-strand breaks. Improved genomic integrity in these cells is linked to a substantial increase in the stability of RAD51 at DNA double-strand break sites and in the overall efficiency of HR. Ablation of BLM also rescues RAD51 foci and HR in cells lacking BRCA2 or XRCC2. These results indicate that the anti-recombinase activity of BLM is of general importance for normal retention of RAD51 at DNA break sites and regulation of HR.
Permeation of CO2 and N2 Through Glassy Poly(Dimethyl Phenylene) Oxide (PPO) under Steady and Pre-Steady State Conditions

Glassy polymers are often used for gas separations because of their high selectivity. Although the dual mode permeation model correctly fits their sorption and permeation isotherms, its physical interpretation is disputed, and it does not describe permeation far from steady state, a condition expected when separations involve intermittent renewable energy sources. To develop a more comprehensive permeation model, we combine experiment, molecular dynamics, and multiscale reaction-diffusion modeling to characterize the time-dependent permeation of N2 and CO2 through a glassy poly(dimethyl phenylene oxide) (PPO) membrane, a model system. Simulations of experimental time-dependent permeation data for both gases in the pre-steady state and steady state regimes show that both single-mode and dual-mode reaction-diffusion models reproduce the experimental observations, and that sorbed gas concentrations lag the external pressure rise. The results point to environment-sensitive diffusion coefficients as a vital characteristic of transport in glassy polymers. 16 17
Dual-wideband bandpass filter with independently controllable center frequencies and wide stopband

In this paper, a dual-wideband bandpass filter (BPF) with independently controllable center frequencies (CFs) and wide stopband suppression is presented using a new quintuple-mode resonator (QMR). By applying the classical odd-/even-mode analysis method, the resonant characteristics of the new QMR have been analyzed. It shows that five modes can be excited, and two of them can be employed to form the lower passband, while the other three modes contribute to the higher passband. For verification, a dual-wideband BPF using the new QMR is designed, fabricated, and tested. Experimental results show that the CFs of the dual-wideband BPF centered at 2.96 GHz and 5.695 GHz with 3 dB fractional bandwidths of 27.7 and 23.4%, respectively. In addition, 20-dB suppression in upper-stopband ranges from 2.23 to 4.04f0, where f0 is the center frequency of the first passband. The measurement results are in good agreement with the prediction results.
ulti~le ~ u t u ~runsmissi~n from s in ~mergency Medicine ~ituutions

Title Telemedicine by mobile communication Author(s) Shimizu, K. Citation IEEE Engineering in Medicine and Biology Magazine, 18(4), 32-44 https://doi.org/10.1109/51.775487 Issue Date 1999-08 Doc URL http://hdl.handle. net/2115/5579 Rights IEEE, Engineering in Medicine and Biology Magaziner,18 , 4, 1999, p32-44 ©1999 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE. ” Type article File Information IEMBM18-4.pdf
Standardization of Smartphone-Related Pictures for Cognitive Bias Tasks of Smartphone Addiction

This study aimed to develop a set of standardized smartphone-related pictures and investigate the possible rating biases for smartphone-related cues among college students with smartphone addiction. College students with (N=18) and without (N=23) smartphone addiction rated four kinds (pictures of apps, pictures of using smartphone, pictures of smartphone brands and pictures of smartphone) of smartphone-related pictures (N=96) on four dimensions: pleasantness, attractiveness, familiarity and craving, and the rating biases for smartphone-related pictures were tested. The results demonstrated significant rating differences on smartphone-related pictures between college students with and without smartphone addiction. Participants’ rating scores in four dimensions were significantly correlated. The overall result of the study is a database of 96 smartphone-related pictures that could be used to validate an implicit measure of cognitive biases for smartphone in college students with smartphone addiction.
ASSOCIATION OF ISCHEMIC STROKE IN CASES WITH ATRIAL FIBRILLATION

This review describes present evidence relating to the atrial fibrillation (AF) and how is it risk factor that may lead to ischemic cerebral stroke, moreover underlying problems and consequences and the progression and development of AF. We performed comprehensive search using biomedical databases; Medline, and Embase, for studies concerned with Association of ischemic stroke in cases with atrial fibrillation published in English language up to, January, 2020. AF is a very common cardiac arrhythmia with substantial cardio morbidity as well as death. The associated threat of embolic occasions, especially embolic cerebrovascular accidents, is its most major complication. The threat of bleeding must be analyzed in every patient with AF prior to initiating anticoagulation to aid direct the appropriate resolution of the technique of stroke prevention and prevent bleeding issues. Stroke avoidance is just one component of an incorporated handling technique to AF, and also interest to signs and symptoms and also indicators and cardio or comorbidity monitoring should certainly likewise be stressed. Corresponding author: Sarah Jafar Sabihah, Please cite this article in press Sarah Jafar Sabihah et al, Association Of Ischemic Stroke In Cases With Atrial Fibrillation. , Indo Am. J. P. Sci, 2020; 07(09). QR code IAJPS 2020, 07 (09), 928-934 Sarah Jafar Sabihah et al ISSN 2349-7750 w w w . i a j p s . c o m Page 929 INTRODUCTION: Atrial fibrillation (AF) is one of the most prevalent scientifically substantial arrhythmias, with a total frequency of around 1 % in the general populace . One of the most scientifically essential troubles from AF hinges on the risk of heart thrombus development and also systemic blood clot. Stroke prevention is an important part of the administration for patients with AF [2]. Independent risk variables for stroke in people with AF consist of age ≥ 65 years, female sex, congestive heart failure, prior stroke or temporary ischemic stroke, high blood pressure, diabetes mellitus and vascular disease. In people with non-valvular AF, anticoagulation treatment (OAC) with warfarin reduces stroke by 64% contrasted to no antithrombotic agents [3,4]. OAC therapy is underused in AF just 50% (USA), 67% (Europe), 75% (Japan), and also 2.5% (China) of AF individuals with CHADS2 or CHA2DS2VASc scores of ≥ 2 get OAC therapy. Determining AF patients in danger for stroke has critical healing and prognostic results. Atrial fibrillation (AF) is among one of the most typical scientific arrhythmias and also belongs to enhanced morbidity as well as death. There is expanding evidence that lots of cardiovascular diseases and also risk variables associated with the event of AF which alone AF is rare [5]. This review describes present evidence relating to the atrial fibrillation and how is it risk factor that may lead to ischemic cerebral stroke, moreover underlying problems and consequences and the progression and development of AF.
Semantic Web against Classic Web ( Contender or Natural Evolution )

Semantic Web have been quietly maturing and spreading, and now they provide a clear way to apply a basic level of formal semantics to the infrastructure and pages of the web and make cooperation between human and computers easier. The Semantic Web is a web of data and also referred to as Web 3.0 which is not a separate Web but an extension of the current one. Moreover, Semantic Web is considered a part of artificial intelligence (AI) research field. The Semantic Web is about two things: it is about common formats for integration and combination of data drawn from diverse sources and it is also about language for recording how the data relates to real world objects. This paper briefly describes and compares Semantic Web, Web 1.0 and Web2.0, in addition to different experts’ points of views in semantic web as well as it discusses the features and capabilities of Semantic Web. Keywords— WWW; Web 1.0; Web 2.0; Semantic Web; Ontology; RDF; Twine; Metadata.
O BJECT -C ENTRIC L EARNING AS N ESTED O PTIMIZATION

Various iterative algorithms have shown promising results in unsupervised decomposition simple visual scenes into representations of humans could intuitively consider objects, but all with different algorithmic and implementational design choices for making them work. In this paper, we ask what the underlying computational problem that all of these iterative approaches are solving. We show that these approaches can all be viewed as instances of algorithms for solving a particular nested optimization problem whose inner optimization is that of maximizing the ELBO with respect to a set of independently initialized parameters for each datapoint. We lastly discuss how our nested optimization formulation reveals connections to similar problems studied in other fields, enabling us to leverage tools developed in these other fields to improve our object-centric learning methods.
Stress ( Takotsubo ) Cardiomyopathy in Poisoned Patients

Purpose: Stress or Takotsubo Cardiomyopathy (TTC) is occasionally described after poisoning, but epidemiologic data are still lacking. We decided to describe the TTC echocardiographic patterns in a toxicological intensive care unit. Methods: Monocentric retrospective study. Results: During 42 months, 973 consecutive patients were admitted and five patients (0.5%) had TTC pattern on echocardiography, typical in 80%. TTC occurred mainly after cardiotoxicant ingestion. Stress cardiomyopathy was associated with poisoning with beta-blockers (n=2), olanzapine (n=1) and chloroquine (n=1) in the multivariate analysis and only in the univaried analysis with venlafaxine (n=1) and tramadol (n=1). Median LVEF was 20%. All TTC patients experienced shock and had more frequently pulmonary edema than the control group. TTC occurrence was significantly associated with mortality (40% versus 6%; OR=10; CI 1.7-61; p=0.01) but this association was not significant in multivariate analysis. Mechanisms are herein hypothesized: catecholamine (endogenous or exogenous) cardiotoxicity, metabolism disturbances (including fatty acid cardiac metabolism), neurological impairment or direct toxicological damage such as myocarditis. Conclusion: TTC echocardiographic patterns mainly caused by cardiotoxicant are rarely reported in poisoned patients (0.5 percent) but can significantly lead to death. Pathophysiology of the causative specific or non specific involved mechanism seems multifactorial.
DMD054213 2187..2196

In this study we compared the in silico predictions of the effect of ABCC1 nonsynonymous single nucleotide polymorphisms (nsSNPs) with experimental data on MRP1 transport function and response to chemotherapeutics and multidrug resistance protein 1 (MRP1) inhibitors. Vectors encoding seven ABCC1 nsSNPs were stably expressed in human embryonic kidney (HEK) cells, and levels and localization of the mutant MRP1 proteins were determined by confocal microscopy and immunoblotting. The function of five of the mutant proteins was determined using cell-based drug and inhibitor sensitivity and efflux assays, and membrane-based organic anion transport assays. Predicted consequences of the mutations were determined by multiple bioinformatic methods. Mutants C43S and S92F were correctly routed to the HEK cell plasma membrane, but the levels were too low to permit functional characterization. In contrast, levels and membrane trafficking of R633Q, G671V, R723Q, A989T, and C1047S were similar to wild-type MRP1. In cell-based assays, all five mutants were equally effective at effluxing calcein, but only two exhibited reduced resistance to etoposide (C1047S) and vincristine (A989T; C1047S). The GSH-dependent inhibitor LY465803 (LY465803 [N-[3-(9-chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]quinolin-5-yl)-cyclohexylmethyl]-benzamide)] was less effective at blocking calcein efflux by A989T, but in a membrane-based assay, organic anion transport by A989T and C1047S was inhibited by MRP1 modulators as well as wild-type MRP1. GSH accumulation assays suggest cellular GSH efflux by A989T and C1047S may be impaired. In conclusion, although six in silico analyses consistently predict deleterious consequences of ABCC1 nsSNPs G671V, changes in drug resistance and inhibitor sensitivity were only observed for A989T and C1047S, which may relate to GSH transport differences.
PII: S1010-7940(02)00400-1

Objective: The objective of this study was to assess improved myocardial protection by performing coronary artery bypass grafting (CABG) on the beating heart. A case-matched study was conducted among patients who underwent CABG either on-pump (group 1), or offpump (group 2). Methods: Forty-five pairs of patients, having a similar clinical profile, were selected on the basis of five variables: age, gender, body surface area, ejection fraction, extent of coronary disease. Operative risk predicted by the The Society of Thoracic Surgeons national database was 1.80 ^ 0.35% in group 1, and 1.89 ^ 0.37% in group 2 (NS). Cold blood cardioplegia and 288C cardiopulmonary bypass were used in group 1. In group 2, beating heart coronary grafting was achieved with the Octopuse 1 and 2 stabilizers. The average number of distal anastomoses was 2.8 ^ 0.1 in group 1 and 2.3 ^ 0.1 in group 2 (P 1⁄4 0:015). Results: There was no significant difference among the groups regarding the trend in cardiac index, left and right ventricular stroke work indexes, and systemic and pulmonary vascular resistance indexes. However, heart rate trend was slower in group 2 (P 1⁄4 0:05). Pharmacological support was required in 65% of the patients in group 1, and in 33% in group 2 (P , 0:001). The total amount of Dobutamine and/or Dopamine administered during the first 48 h was 3914 ^ 1306 g/kg in group 1 and 1645 ^ 697 g/kg in group 2 (P 1⁄4 0:049). Release of creatine kinase MB mass isoenzyme (CK-MB mass) was markedly reduced in group 2 (P , 10). Conclusions: Hemodynamic outcome following off-pump CABG is similar to on-pump CABG but the need for inotropic support is significantly reduced and CPK-MB mass release is markedly lower. q 2002 Elsevier Science B.V. All rights reserved.
Afunctional coreofthemitochondrialgenomemaintenanceprotein Mgm101p inSaccharomyces cerevisiae determinedwitha temperature-conditional allele

Analysis of Mgm101p isolated from mitochondria shows that the mature protein of 27.6 kDa lacks 22 amino acids from the N-terminus. This mitochondrial targeting sequence has been incorporated in the design of oligonucleotides used to determine a functional core of Mgm101p. Progressive deletions, although retaining the targeting sequence, reveal that 76 N-terminal and six C-terminal amino acids of Mgm101p can be removed without altering the ability to complement an mgm101-1 temperature-sensitive mutant. However, this active core is unable to complement mgm101 null mutants, suggesting that the Mgm101p might need to form a dimer or multimer to be functional in vivo. The active core, enriched in basic residues, contains 165 amino acids with a pI of 9.2. Alignment with 22 Mgm101p sequences from other lower eukaryotes shows that a number of amino acids are highly conserved in this region. Random mutagenesis confirms that certain critical amino acids required for function are invariant across the 23 proteins. Searches in the PFAM database revealed a low level of structural similarity between the active core and the Rad52 protein family.
1 Characterization of Pulp Derived Nanocellulose Hydrogels using 1 AVAP ® Technology 2 3

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ISSN 2320-5407 International Journal of Advanced Research (2015), Volume 3, Issue 5, 658-664

N. Sunitha Objective : to compare characteristics of the gram stain , culture, Real-time PCR to detection pathogenic bacteria in CSF samples of patients were suspected of acute bacterial meningitis. Methods: 100 CSF sample were suspected of acute bacterial meningitidis Gram stain , bacterial culture, Real-time PCR based on SYBR Green I fluorescent dye for detection of Nisseria meningitidis in all samples. Results: Gram stain and bacteria culture for all samples were positive in 5 case (5%) including two bacterial genus Listeria monocytogenes in four case (80%) and Staphylococcus aureus in one case (20%) while in RT-PCR based on SYBR Green for detection of SodC gene which is specific gene to diagnosis of N. meningitidis were positive in 42 case (42%) . Conclusion: RT-PCR method is rapid , sensitive and specific diagnostic test for acute meningitis . RTPCR test was positive in 42 case (42%) and all these case was N. meningitidis .
Acceptance of Social Network Web Sites the Effects of Social Acceptance of Social Network Web Sites the Effects of Social Influence Influence

This study has proposed and empirically tested a social network (SN) Web site acceptance model that incorporates social influence, social motives and technology acceptance factors. The three processes of social influence: compliance, identification and internalization are used to explain the causal antecedents of social motives, technology acceptance factors and intention. An online survey generates 274 usable responses. The results indicate that social influence has positive effects on intention, social motives, and perceived usefulness and enjoyment through compliance, identification and internalization respectively. The two social motives: sociability and status play a significant role in the proposed model.
Adaptive Neuro Fuzzy Inference System for Software Development Effort Estimation

: Software estimation such as cost estimation, effort estimation, quality estimation and risk analysis is a major challenge for Software Projects. The literature shows several algorithmic cost estimation models such as Boehm’s COCOMO(Constructive Cost Model), Albrecht's' Function Point Analysis, Putnam’s SLIM(Software Lifecycle Management), ESTIMACS(Macro Estimation Model) etc., where each model has its own pros and cons for estimation, there is still a need to find a model that gives accurate estimates. This paper is a modest attempt in explaining the soft computing models using Adaptive Neuro Fuzzy Inference System (ANFIS) which are designed to improve the performance of the network that suits to the COCOMO Model for software development effort prediction. ANFIS Models are created using Triangular, GBell, Trapezoidal and Gauss membership functions. A case study based on NASA 93 projects compares the proposed models with the Intermediate COCOMO. In the results which were analyzed using five different criterions Variance Accounted For (VAF), Mean Absolute Relative Error (MARE), Variance Absolute Relative Error(VARE), Mean Balance Relative Error (Mean BRE) and Prediction ,it is observed that the proposed ANFIS models combined with the neural network adaptive capabilities and the fuzzy inference system indicate a high level of efficiency with an accuracy of 99% and particularly ANFIS Model using Triangular Membership function provided better results.
Smart training environment for power electronics

The idea of the paper is to present a successful symbiosis of the products of the leading firms in the electronics – National Instruments and Texas Instruments. The developed test bench is composed of hardware for data acquisition and control (sbRIO), working with the LabVIEW environment and the novel Power Management Lab Kit (PMLK) educational boards. The manipulation of these hi-tech boards becomes more accessible for a broader range of students, including undergraduates in schools, with the use of LabVIEW virtual instruments (VI), which assist the trainees in the manipulation of the kits – for example if a incompatible working configuration is set, the VI will pop up a message describing the result if its execution. Moreover it will provide guidance for choosing the right setup along the active decisions from the student and also with the VI can be taken measurements, without the need of external hardware.
Comparison of Gamma Nail and Locking Plate in Treatment of Intertrochanteric Fractures

Background and Objectives: The effective method for the surgical treatment of intertrochanteric femoral fractures has not been established. Two commonly used techniques are Gamma nail and locking plate. We performed a retrospective study to compare these two treatment strategies. Materials and Methods: A total of 42 patients were selected for review. Each patient was treated by one of the two methods. Data including operative time, blood loss, pain scale, radiological result, Harris hip score and operative complications were collected. Results: Twenty-two patients were treated with Gamma nail and the rest (20) were treated with locking plate fixation. Gamma nail group was associated with significantly shorter operative time and length of hospital stay, lesser blood loss and lower postoperative pain (P < 0.05). There was no significant difference in Harris hip score, radiological result and complications between the two groups. Conclusion: Gamma nail technique is similar in effectiveness to the locking plate in the treatment of intertrochanteric femoral fractures, but with a shorter operative time and hospital stay, lesser blood loss and lower