Miracle-dz/UniFAR-FTUs huggingface dataset:
The Changes of Functional Connectivity Strength in Electroconvulsive Therapy for Depression: A Longitudinal Study

Electroconvulsive therapy (ECT) is an effective treatment for depression, but the mechanism of ECT for depression is still unclear. Recently, neuroimaging studies have reported that the prefrontal cortex, hippocampus, angular gyrus, insular and other brain regions are involved in the mechanism of ECT for depression, and these regions are highly overlapped with the location of brain hubs. Here, we try to explore the effects of ECT on the functional connectivity of brain hubs in depression patients. In current study, depression patients were assessed at three time points: prior to ECT, at the completion of ECT and about 1 month after the completion of ECT. At each time point, resting-state functional magnetic resonance imaging, assessment of clinical symptoms and cognition function were performed respectively, which was compared with 20 normal controls. Functional connectivity strength (FCS) was used to identify brain hubs. The results showed that FCS of left angular gyrus in depression patients significantly increased after ECT, accompanied by improved mood. The changed FCS in depression patients recovered obviously at 1 month after the completion of ECT. It suggested that ECT could modulate functional connectivity of left angular gyrus in depression patients.
Assessing the impact of retraction on the citation of randomized controlled trial reports: an interrupted time-series analysis

Objectives To assess the impact of retraction on the citation of randomized controlled trials. Methods We used an interrupted time-series with matched controls. PubMed, CINHAL, Google and the Retraction Watch Database were searched. We identified retracted publications reporting the results of randomized controlled trials involving human participants with two years of available data before and after retraction. We obtained monthly citation counts across all articles for the 24 months before and after retraction, from Web of Science. We used a Poisson segmented regression to detect changes in the level and trend of citation following retraction. We also undertook a matched control analysis of unretracted randomized controlled trials and a sensitivity analysis to account for cases of large-scale, well-advertised fraud. Results We identified 387 retracted randomized controlled trial reports, of which 218 (56.3%) were included in the interrupted time-series analysis. A reduction of 22.9% (95% CI 4.0% to 38.2%, p = 0.02) was observed in the number of citations in the month after retraction, and a further reduction of 1.9% (95% CI 0.4% to 3.5%, p = 0.02) per month in the following 24 months, relative to the expected trend. There was no evidence of a statistically significant reduction among the matched controls. Authors with a large number of retractions saw a 48.2% reduction at the time of retraction (95% CI 17.7% to 67.3%, p = 0.01). Other cases had a more gradual reduction with no change at the time of retraction and a 1.8% reduction per month in the following 24 months (95% CI 0.2% to 3.4%, p = 0.03). Conclusions Retractions of randomized controlled trial reports can be effective in reducing citations. Other factors, such as the scale of the retractions and media attention, may play a role in the effectiveness of the reduction.
Differential gene regulation underlies variation in melanic plumage coloration in the dark‐eyed junco (Junco hyemalis)

Colour plays a prominent role in species recognition; therefore, understanding the proximate basis of pigmentation can provide insight into reproductive isolation and speciation. Colour differences between taxa may be the result of regulatory differences or be caused by mutations in coding regions of the expressed genes. To investigate these two alternatives, we studied the pigment composition and the genetic basis of coloration in two divergent dark‐eyed junco (Junco hyemalis) subspecies, the slate‐coloured and Oregon juncos, which have evolved marked differences in plumage coloration since the Last Glacial Maximum. We used HPLC and light microscopy to investigate pigment composition and deposition in feathers from four body areas. We then used RNA‐seq to compare the relative roles of differential gene expression in developing feathers and sequence divergence in transcribed loci under common‐garden conditions. Junco feathers differed in eumelanin and pheomelanin content and distribution. Within subspecies, in lighter feathers melanin synthesis genes were downregulated (including PMEL, TYR, TYRP1, OCA2 and MLANA), and ASIP was upregulated. Feathers from different body regions also showed differential expression of HOX and WNT genes. Feathers from the same body regions that differed in colour between the two subspecies showed differential expression of ASIP and three other genes (MFSD12, KCNJ13 and HAND2) associated with pigmentation in other taxa. Sequence variation in the expressed genes was not related to colour differences. Our findings support the hypothesis that differential regulation of a few genes can account for marked differences in coloration, a mechanism that may facilitate the rapid phenotypic diversification of juncos.
TUS: A Transactional Update Service for SDN Applications

In this paper, we design a network update service for SDN applications to transactionally update the network. We name our system TUS, which is a layer sitting between the SDN controller and SDN applications. SDN applications can call TUS's interfaces to achieve atomicity, consistency, isolation, and durability guarantee for network updates, which eases the application's programming. TUS provides APIs for consistent update, uses logs for atomic update, applies optimistic concurrency control (OCC) for inter-update isolation, and checks each asynchronous rule update for durability. These design choices are decided by network unique characteristics and challenges --- OCC can isolate network updates from volatile network states and checking asynchronous rule update is also used in implementing consistency guarantee in multi-phase network update. We prototype TUS, validate it consistency guarantee and failure recovery effectiveness, and also measure the overhead introduced by TUS logs.
A qualitative inquiry of old people's health literacy in situations of health uncertainty

BACKGROUND This paper examines the health literacy of seniors and the strategies they use to deal with health uncertainty in the context of changes in the health system in Israel that have created a need to examine health literacy in this sector of the population who use the health system the most. The oldest were born and grew up in an era when a physician's knowledge was unchallenged; now, they find it difficult to cope with the expectation of patients taking a role in decision making. METHODS In-depth interviews were carried out with 17 seniors between the ages of 70-87 that focused on their perception of their health and their health literacy. Data were analysed using thematic analysis. FINDINGS Seniors used different information sources when looking for medical information. Participants reported three coping mechanisms that help them deal with the uncertainty: disregarding the problem, relying on the physician and searching for information. CONCLUSIONS The study found different levels of health literacy among participants but, overall, participants who lead an active and optimistic lifestyle tend to take more responsibility for their health and have higher health information literacy.
Detection of Carbapenemase-Producing Enterobacteriaceae in Positive Blood Culture Using an Immunochromatographic RESIST-4 O.K.N.V. Assay

We evaluated the performance of the RESIST-4 O.K. N.V. assay (Coris) with 98 isolates to detect OXA-48-like and KPC-, NDM-, and VIM-type carbapenemases directly on positive human blood cultures. ABSTRACT We evaluated the performance of the RESIST-4 O.K. N.V. assay (Coris) with 98 isolates to detect OXA-48-like and KPC-, NDM-, and VIM-type carbapenemases directly on positive human blood cultures. OXA-48-like and KPC-type isolates were correctly detected, but the detection of NDM- and VIM-type carbapenemases was weak and variable. We show that repeating the test on a 4-h subculture improves the detection of NDM- and VIM-type carbapenemases to 100%.
Injectable Chitosan Hydrogels with Enhanced Mechanical Properties for Nucleus Pulposus Regeneration.

IMPACT STATEMENT A thermosensitive chitosan-based hydrogel was developed, which mimics the mechanical properties of the human nucleus pulposus (NP) tissue and provides a suitable environment for seeded NP cells to live and produce glycosaminoglycans. This scaffold is injectable through 25G needle and rapidly gels in vivo at body temperature. It has the potential to restore mechanical properties and stimulate biological repair of the degenerated intervertebral disc (IVD). It could therefore be used for the minimally invasive treatment of degenerated IVD, which affects more than one person out of five in the world.
A possible role for fumagillin in cellular damage during host infection by Aspergillus fumigatus

ABSTRACT Virulence mechanisms of the pathogenic fungus Aspergillus fumigatus are multifactorial and depend on the immune state of the host, but little is known about the fungal mechanism that develops during the process of lung invasion. In this study, microarray technology was combined with a histopathology evaluation of infected lungs so that the invasion strategy followed by the fungus could be described. To achieve this, an intranasal mice infection was performed to extract daily fungal samples from the infected lungs over four days post-infection. The pathological study revealed a heavy fungal progression throughout the lung, reaching the blood vessels on the third day after exposure and causing tissue necrosis. One percent of the fungal genome followed a differential expression pattern during this process. Strikingly, most of the genes of the intertwined fumagillin/pseurotin biosynthetic gene cluster were upregulated as were genes encoding lytic enzymes such as lipases, proteases (DppIV, DppV, Asp f 1 or Asp f 5) and chitinase (chiB1) as well as three genes related with pyomelanin biosynthesis process. Furthermore, we demonstrate that fumagillin is produced in an in vitro pneumocyte cell line infection model and that loss of fumagillin synthesis reduces epithelial cell damage. These results suggest that fumagillin contributes to tissue damage during invasive aspergillosis. Therefore, it is probable that A. fumigatus progresses through the lungs via the production of the mycotoxin fumagillin combined with the secretion of lytic enzymes that allow fungal growth, angioinvasion and the disruption of the lung parenchymal structure.
Constructing Financial Sentimental Factors in Chinese Market Using Natural Language Processing

In this paper, we design an integrated algorithm to evaluate the sentiment of Chinese market. Firstly, with the help of the web browser automation, we crawl a lot of news and comments from several influential financial websites automatically. Secondly, we use techniques of Natural Language Processing(NLP) under Chinese context, including tokenization, Word2vec word embedding and semantic database WordNet, to compute Senti-scores of these news and comments, and then construct the sentimental factor. Here, we build a finance-specific sentimental lexicon so that the sentimental factor can reflect the sentiment of financial market but not the general sentiments as happiness, sadness, etc. Thirdly, we also implement an adjustment of the standard sentimental factor. Our experimental performance shows that there is a significant correlation between our standard sentimental factor and the Chinese market, and the adjusted factor is even more informative, having a stronger correlation with the Chinese market. Therefore, our sentimental factors can be important references when making investment decisions. Especially during the Chinese market crash in 2015, the Pearson correlation coefficient of adjusted sentimental factor with SSE is 0.5844, which suggests that our model can provide a solid guidance, especially in the special period when the market is influenced greatly by public sentiment.
Enhancing the quality of service of mobile video technology by increasing multimodal synergy

ABSTRACT Bandwidth is still a limiting factor for the Quality of Service (QoS) of mobile communication applications. In particular, for Voice over IP the QoS is not yet as good as for common, well-engineered, public-switched telephone networks. Multisensory communication has been identified as a possibility to moderate this limitation. One of the strengths of mobile video technology lies in its combination of visual and auditory modalities. However, one of the most salient features of mobile video applications is its small screen size. To test the potential of multimodal synergy for mobile devices, we assessed to what extent small screens affect multimodal synergy. This potential was assessed in an experiment with 54 participants, who conducted a standardised video-listening test for three talking-heads videos with a signal-to-noise ratio of –9 dB. The videos were presented on three different screen sizes, whilst keeping the video and auditory signals equal. Compared to a ground truth based on 359 participants, intelligibility was found to be significantly higher when using a large screen than when using a small screen. This indicates that mobile video technology has the potential for a significant multimodal synergy to which screen size is a substantial constraint. To optimally benefit from their multimodal potential, we offer suggestions on how to increase the effective screen size for small screen (e.g. mobile) devices and applications through elaborating the most relevant (visual) features. We conclude that knowledge about human sensory processing can alleviate the identified constraint and maximise the potential QoS of mobile video technology.
Emotional Regulation in Women with Chronic Fatigue Syndrome and Depression: Internal Representations and Adaptive Defenses

Chronic fatigue syndrome (CFS) presents challenges in differential diagnosis and treatment. Complicating diagnosis is that its symptoms overlap with those of depression. This study applies psychoanalytic concepts to understand emotional regulation (ER) in women with CFS and/or depression. One hundred eighty-six women were assigned to four groups and compared: (a) CFS plus high er depression (CFS-HD); (b) CFS plus lower depression (CFS-LD); (c) depressive disorder (DD); and (d) healthy controls (HC). ER was operationalized by measures of capacity to form internal representations and adaptive defenses. The study’s premise was that difficulties metabolizing emotions psychologically would be associated with their greater somatic expression. Some support was found for the hypothesis that CFS participants would exhibit more impairment in representing emotions and in adaptive defenses compared to the DD and HC groups, but this held only for the CFS-HD group. Although CFS-LD participants were expected to be more purely somatizing than the CFS-HD group, they instead showed more sophisticated capacities for ER than that group and recalled less distressing early relationships, revealing more resilience. Still, however, we found support for somatization in some CFS sufferers: Within both the CFS-HD and the CFS-LD groups, weaknesses in representing emotions and in defensive functioning were associated with more severe physical symptoms. Clinically, the heterogeneity of CFS and those who suffer from it indicates the need for individual assessment and depression treatment.
EEG-based Inter-Subject Correlation Schemes in a Stimuli-Shared Framework: Interplay with Valence and Arousal

Affective computing is confronted to high inter-subject variability, in both emotional and physiological responses to a given stimulus. In a stimuli-shared framework, that is to say for different subjects who watch the same stimuli, Inter-Subject Correlation (ISC) measured from Electroencephalographic (EEG) recordings characterize the correlations between the respective signals at the different EEG channels. In order to investigate the interplay between ISC and emotion, we propose to study the effect of valence and arousal on the ISC score. To this end, we exploited various computational schemes corresponding to different subsets of the dataset: all the data, stimulus-wise, subject pairwise, and both stimulus-wise and subject pairwise. We thus applied these schemes to the HCI MAHNOB and DEAP databases. Our results suggest that the ISC score decreases with valence and increases with arousal, as already shown by previous results on functional MRI.
Example-Based English to Arabic Machine Translation: Matching Stage Using Internal Medicine Publications

Automatic machine translation becomes an important source of translation nowadays. It is a software system that translates a text from one natural language to one (many) natural language. On the web, there are many machine translation systems that give the reasonable translation, although the systems are not very good. Medical records contain complex information that must be translated correctly according to its medical meaning not its English meaning only. So, the quality of a machine translation in this domain is very important. In this paper, we present using matching stage from Example-Based Machine Translation technique to translate a medical text from English as source language to Arabic as the target language. We have used 259 medical sentences that are extracted from internal medicine publications for our system. Experimental results on BLUE metrics showed a decreased performance 0.486 comparing to GOOGLE translation which has an accuracy result about 0.536.
An Iterative Refinement Approach for Social Media Headline Prediction

In this study, we propose a novel iterative refinement approach to predict the popularity score of the social media meta-data effectively. With the rapid growth of the social media on the Internet, how to adequately forecast the view count or popularity becomes more important. Conventionally, the ensemble approach such as random forest regression achieves high and stable performance on various prediction tasks. However, most of the regression methods may not precisely predict the extreme high or low values. To address this issue, we first predict the initial popularity score and retrieve their residues. In order to correctly compensate those extreme values, we adopt an ensemble regressor to compensate the residues to further improve the prediction performance. Comprehensive experiments are conducted to demonstrate the proposed iterative refinement approach outperforms the state-of-the-art regression approach.
Quantification of protein markers monitoring the pre-analytical effect of blood storage time before plasma isolation using 15 N metabolically labeled recombinant proteins.

In the hospital, blood samples are collected to monitor patients' health states, and thus various protein-based clinical methods have been developed. However, some proteins are found to change in abundances during the process of blood collection and storage. In order to account such pre-analytical effects, we performed liquid chromatography multiple reaction monitoring mass spectrometry (LC-MRM-MS) on 15 selected proteins in plasma samples prepared by varying storage time and temperature of whole blood prior to plasma isolation. Two cytosolic proteins, profilin-1 (PFN1) and thymosin beta-4 (TMSB4X), were absolutely quantified using 15 N-labeled recombinant proteins spiked externally. The other 13 proteins were quantified in a relative way compared with the two reference proteins. Triplicated LC-MRM-MS measurements showed that the median CV of MRM peak areas was 5.7%. The amounts of PFN1 and TMSB4X increased rapidly depending on the storage time between blood collection and plasma preparation. It indicates the leakage of cellular components into the plasma fraction. Relative quantification further revealed that five proteins including PFN1, S10A8, S10A9, S10A11, and TMSB4X showed significant difference (P < 0.05). We further monitored PFN1 and TMSB4X on 40 samples collected for protein diagnostics under a typical clinical study condition. Compared with the plasma samples prepared within a day, the level of both PFN1 and TMSB4X increased in the plasma samples prepared from the blood collected the day before and kept overnight at 4°C (0.51 to 3.11 μg/mL for PFN1 and 0.98 to 5.36 μg/mL for TMSB4X in average). Our result suggests an effort of assuring plasma quality for accurate protein-based diagnosis or biomarker discovery and validation.
Microsatellite-Based Genetic Structure and Diversity of Local Arabian Sheep Breeds

The genetic diversity of the sheep breeds in the Arab countries might be considered to be a mirror of the ecology of the region. In this study, the genetic structure and diversity of sheep breeds from Saudi Arabia (Harri, Najdi, Naemi, Arb, and Rufidi) and Awassi sheep from Jordan as an out-group were investigated using 19 microsatellites. All the breeds had high intra-population genetic diversity expressed as allelic number (7.33) and richness (2.9) and, expected heterozygosity (0.77). Structure analysis revealed three main gene pools underlying the ancestral genetic diversity of the study populations. The first pool had Harri, Najdi, and Rufidi breeds; the second had Naemi and Awassi breeds, and the third had the Arb breed which was significantly differentiated from the other breeds. Factorial correspondence analysis lent further support to the presence of the three gene pools. Although the outgroup Awassi sheep was more clearly differentiated, it still genetically close to Naemi sheep. The differentiation of the Arb breed could have been resulted from geographic and reproductive isolation. On the other hand, the genetic structure of the other two gene pools could be the result of the past and recent gene flow between individuals reared in the region known to be the center for animal husbandry and trading until the current time.
The role of design fiction in participatory design processes

Participatory design is in essence very malleable as any design technique could lend itself to it, as long as users and stakeholders are involved. Design fictions however, have more often been used as either a vehicle for critical designs, or as a sheer design tool, created by designers for designers as a means to drive ideation. In the 2010s however, the HCI community has opened up for using design fictions in conjunction with participatory methods and in parallel, researchers have started to explore the practices of creating and using fictions more thoroughly. In response to this, this workshop aims to explore if, how, and when in the design process participatory design practices and design fictions can be combined. We aim to create a first overview of the combined Participatory Design / Design Fiction process, including a set of practical examples. In this we invite not only interaction design researchers and practitioners, but also participants from related fields such as creative writers and artists in general.