Miracle-dz/UniFAR-FTUs huggingface dataset:
COMPUTER-AIDED MANUFACTURING , JUST IN TIME PRODUCTION , TOTAL QUALITY MANAGEMENT AND USE OF BALANCED SCORECARD MEASURES : AN EMPIRICAL STUDY

Performance measurement systems have been altering according to the high-level competitive characteristics of modern manufacturing environments. Balanced scorecard is one of the results of these alternations. In this study the relationship between the balanced scorecard as a new performance measurement system and the production and management techniques such as Computer Aided Manufacturing(CAM), Just in Time(JIT) and Total Quality Management(TQM) that have been largely discussed and kept in the forefront will tried to be explicated. In this frame, by using the data collected from 122 manufacturing businesses among the first 500 large businesses in Turkey in the year 2006, this paper examines how a multiple performance measurement system is associated with applications of CAM, JIT and TQM. The results show that greater emphasis on the usage of a multidimensional performance measurement system directed at performance evaluation is associated with making greater use of CAM, JIT and TQM system.
If electronic medical records are so great, why aren't family physicians using them?

OBJECTIVE The chasm theory of marketing states that fundamental differences exist between early adopters of technology and the mainstream marketplace, making it difficult for technology to transition to the mainstream market. We investigated possible differences in attitudes and beliefs about electronic medical records (EMRs) between current EMR users (early market) and nonusers (mainstream market). STUDY DESIGN Cross-sectional mail survey. POPULATION Active members in the Indiana Academy of Family Physicians 2000-2001 membership database (N = 1328). OUTCOMES MEASURED Differences in attitudes, beliefs, and demographic characteristics of EMR users and nonusers. RESULTS The overall return rate was 51.7%; 14.4% of respondents currently use an EMR. Electronic medical record users were more likely to practice in urban areas or to be hospital-based and reported seeing fewer patients. Nonusers were less likely to believe that (1) physicians should computerize their medical records; (2) current EMRs are a useful tool for physicians; (3) EMRs improve quality of medical records and decrease errors; and (4) it is easy to enter data into current EMRs. Nonusers were more likely to believe that paper records are more secure and more confidential than EMRs. Both users and nonusers believed that current EMRs are too expensive. CONCLUSIONS A chasm exists between EMR users and nonusers regarding issues that affect EMR implementation, including necessity, usefulness, data entry, cost, security and confidentiality. To reach full implementation of EMRs in family medicine, organizations should use these data to target their research, education, and marketing efforts.
A novel method of culturing human oral mucosal epithelial cell sheet using post-mitotic human dermal fibroblast feeder cells and modified keratinocyte culture medium for ocular surface reconstruction

Background/aims To cultivate human oral mucosal epithelial cell sheets with post-mitotic human dermal fibroblast feeder cells and modified keratinocyte culture medium for ocular surface reconstruction. Methods Human oral mucosal epithelial cells obtained from three healthy volunteers were cultured with x-ray-treated dermal fibroblasts (fibroblast group) and NIH/3T3 feeder layers (3T3 group) on temperature-responsive culture dishes. Media were supplemented using clinically approved products. Colony-forming efficiency was determined in both groups. Histological and immunohistochemical analyses were performed for cell sheets. Cell viability and purity of cell sheets were evaluated by flow cytometry. Results Colony-forming efficiency in the fibroblast group was similar to that in the 3T3 group. All cell sheets were well stratified and harvested successfully. The expression patterns of keratin 1, 3/76, 4, 10, 12, 13, 15, ZO-1 and MUC16 were equivalent in both groups. The percentage of p63-positive cells in the fibroblast group (46.1±4.2%) was significantly higher than that in the 3T3 group (30.7±7.6%) (p=0.038, t test). The cell viability and purity were similar between the two groups. Conclusion This novel culture method using dermal fibroblasts and pharmaceutical agents provides a safe cell processing system without xenogenic feeder cells for ocular surface reconstruction.
The Virtuous Drinker: Character Virtues as Correlates and Moderators of College Student Drinking and Consequences

Abstract Objective: The present study examined the relationship between alcohol use and positive psychology's character virtues 1 in a college student sample. Each of the virtues of wisdom, courage, humanity, justice, temperance, and transcendence were examined as protective factors and moderators of drinking consequences. Participants: This sample included 425 undergraduate students at a large Northwest University (69% female; 52% Caucasian, 34% Asian). Methods: Participants completed paper and pencil questionnaires during October and November 2006 in exchange for extra credit in psychology classes. Results: Higher temperance scores were associated with abstinence, lower risk drinking, and fewer consequences among heavy drinkers; both increased justice and transcendence were independently associated with abstinence only; and wisdom, courage, and humanity were not associated with any outcomes. Conclusions: The associations between virtues and college student drinking support a collaboration between addictive behaviors and positive psychology to address college student drinking and minimize consequences.
The Remote-Clique Problem Revisited

Given a positive integer k and a complete graph with non-negative edge weights that satisfy the triangle inequality, the remote-clique problem is to find a subset of k vertices having a maximum-weight induced subgraph. A greedy algorithm for the problem has been shown to have an approximation ratio of 4, but this analysis was not shown to be tight. In this thesis, we present an algorithm called d-Greedy Augment that generalizes this greedy algorithm (they are equivalent when d = 1). We use the technique of factor-revealing linear programs to prove that d-Greedy Augment, which has a running time of O(kdnd ), achieves an approximation ratio of (2k ? 2)/(k + d ? 2). Thus, when d = 1, d-Greedy Augment achieves an approximation ratio of 2 and runs in time O(kn), making it the fastest known 2-approximation for the remote-clique problem. Beyond proving this worst-case result, we also examine the behavior of d-Greedy Augment in practice. First, we provide some theoretical results regarding the expected case performance of d-Greedy Augment on random graphs, and second, we describe data from some experiments that test the performance of d-Greedy Augment and related heuristics. Type of Report: Other Department of Computer Science & Engineering Washington University in St. Louis Campus Box 1045 St. Louis, MO 63130 ph: (314) 935-6160 The Remote-Clique Problem Revisited Undergraduate Honors Thesis Benjamin E. Birnbaum Advisors: Jonathan S. Turner Kenneth J. Goldman
Effects of mescaline, LSD-25, and adrenochrome on depth electrograms in man.

In a recent report concerning the reversibility by chlorpromazine of psychoses induced by means of mescaline andd-lysergic acid diethylamide (LSD-25), careful attention was given to the clinical and electroencephalographic changes.1Although the clinical changes of this reversal effect were immediate and striking, the conventional electroencephalographic changes were minimal, and it was difficult to assess them. It was noted in another recent study that mescaline and LSD-25 failed to activate temporal-lobe epilepsy either clinically or electroencephalographically.2 Because of these factors, it was hoped that depth electrographic studies might be fruitful in elucidating the effects of these drugs. It was hoped also that study by means of depth electrography of the effects of adrenochrome might elucidate its reported actions of inducing a psychosis without insight in volunteers3and increasing the paroxysmal discharges in the electroencephalograms of epileptics.4Scalp electroencephalography and depth electrography were undertaken as specific
Non‐fibrosing sclerosing epithelioid fibrosarcoma: an unusual variant

Sclerosing epithelioid fibrosarcoma (SEF), first described in 1995, is a rare aggressive sarcoma morphologically defined by "epithelioid fibroblasts arranged in distinct cords and nests in a densely sclerotic, hyalinised stroma". SEF can mimic metastatic carcinoma within desmoplastic stroma, lymphoma and other mesenchymal neoplasms such as myoepithelioma, making it difficult to diagnose. In a subset of cases there is morphological overlap between SEF and low grade fibromyxoid sarcoma (LGFMS), a low grade fibroblastic sarcoma. Progression of LGFMS to SEF in single cases is well documented. Recent studies detected EWSR1-CREB3L1 fusion transcripts in a high proportion of SEF. This article is protected by copyright. All rights reserved.
Genome‐Wide Linkage Analysis in a General Population Sample Using σ2A Random Effects (SSARs) Fitted by Gibbs Sampling

We used variance components analysis to investigate the underlying determinants of the quantitative phenotypes (Q1–Q5) and their interrelationships in replicate 42 of the Genetic Analysis Workshop 12 simulated general population. Variance components models were fitted using Gibbs sampling in WinBUGS v1.3. Sigma‐squared‐A‐random‐effects (SSARs) were estimated for each phenotype, and were used as derived phenotypes in subsequent linkage analyses. Whole‐genome, multipoint linkage analyses were based upon a new Haseman‐Elston identity‐by descent sib‐pair method that takes a weighted combination of the trait‐sum and trait‐difference. The five quantitative traits simulated were closely correlated with each other and with affection status. The whole‐genome screen of quantitative traits associated with the simulated complex disease suggested that one or more major loci regulating Q1 localizes to chromosome 2p and that one or more major loci regulating Q5 may localize to chromosome Ip. © 2001 Wiley‐Liss, Inc.
Lack of Myostatin Reduces MyoD Induced Myogenic Potential of Primary Muscle Fibroblasts

Conversion of skin fibroblasts into myoblasts by transducing the cells with myogenic master regulator MyoD has been in practice for more than two decades. The purpose of such conversion is due to scarcity of muscle biopsies during muscle wasting, hence conversion of fibroblasts to myogenic lineage from various genetic backgrounds offers a great alternative for cell therapies. Here, we have investigated if eliminating Myostatin, a potent negative regulator of myogenesis, could improve the myogenic conversion of fibroblasts. In the present study, we have isolated primary muscle fibroblasts from the skeletal muscles of wild‐type (WT) and myostatin null (Mstn−/−) mice and transduced the muscle fibroblasts with MyoD using adenoviral, lentiviral transduction, and electroporation methods. In contrast to what we predicted, it is only in WT muscle fibroblasts we detected significant ectopic expression of MyoD, and myogenic conversion. Muscle fibroblasts from Mstn−/− genotype failed to take up as much MyoD using the three methods and, therefore, failed to form myotubes. The aforesaid condition of greater MyoD uptake by WT muscle fibroblasts was attributed to the presence of adenoviral receptors, which facilitated adenoviral transduction. However, in Mstn−/− fibroblasts we detected negligible levels of adenovirus receptors. Moreover, we also detected significantly higher levels of MyoD antagonists, c‐Fos, c‐Jun, and cyclin D1 in Mstn−/− muscle fibroblasts. Taken together, our results demonstrate that lack of myostatin reduces myogenic potential of muscle fibroblasts by inhibiting MyoD function. J. Cell. Biochem. 115: 1908–1917, 2014. © 2014 Wiley Periodicals, Inc.
Vallecula Entry During a Laryngectomy

INTRODUCTION Laryngeal cancer represents one of the most common head and neck malignancies, accounting for approximately 1.3% of all new cancers. Despite advances in the treatment of laryngeal cancer with techniques and therapies to preserve laryngeal function, total laryngectomy remains a standard surgical procedure for the treatment of advanced laryngeal carcinoma. Since Theodore Billroth performed the first laryngectomy for laryngeal cancer in 1873, many variations of the technique have been described. Surgeons use different techniques in terms of the type of incision, the opening of the trachea and oropharynx, the pharyngeal closure, and voice rehabilitation. One of the most difficult and critical steps of the operation remains the pharyngeal entry at the level of the vallecula, as the surgeon can easily dissect into the tongue base or the pre-epiglottic space. We describe a technique of entry into the vallecula using a laryngoscope with a Polio blade as a guide. This directs the surgeon to the exact entry point into the pharynx, avoiding potential complications at this level.
Interfacing Sentential and Discourse TAG-based Grammars

Tree-Adjoining Grammars (TAG) have been used both for syntactic parsing, with sentential grammars, and for discourse parsing, with discourse grammars. But the modeling of discourse connectives (coordinate conjunctions, subordinate conjunctions , adverbs. .) in TAG-based formalisms for discourse differ from their modeling in sentential grammars. Because of this mismatch, an intermediate, not TAG-related, processing step is required between the sentential and the discourse processes, both in parsing and in generation. We present a method to smoothly interface sentential and discourse TAG grammars, without using such an intermediate processing step. This method is based on Abstract Categorial Grammars (ACG) and relies on the modularity of the latter. It also provides the possibility, as in D-STAG, to build discourse structures that are direct acyclic graphs (DAG) and not only trees. All the examples may be run and tested with the appropriate software.
Mortality and Morbidity During Delivery Hospitalization Among Pregnant Women With Epilepsy in the United States.

IMPORTANCE Between 0.3% and 0.5% of all pregnancies occur among women with epilepsy. Evidence suggests an increase in perinatal morbidity and mortality among women with epilepsy. However, these risks have not been quantified in large population-based samples. OBJECTIVE To report on the risk for death and adverse outcomes at the time of delivery for women with epilepsy in the United States. DESIGN, SETTING, AND PARTICIPANTS Retrospective cohort study of pregnant women identified through delivery hospitalization records from the 2007-2011 Nationwide Inpatient Sample. From this representative sample of 20% of all US hospitals, we obtained a weighted sample of delivery hospitalizations from 69 385 women with epilepsy and 20 449 532 women without epilepsy. MAIN OUTCOMES AND MEASURES Obstetrical outcomes including maternal death, cesarean delivery, length of stay, preeclampsia, preterm labor, and stillbirth. RESULTS Women with epilepsy had a risk of death during delivery hospitalization of 80 deaths per 100 000 pregnancies, significantly higher than the 6 deaths per 100 000 pregnancies found among women without epilepsy (adjusted odds ratio [OR], 11.46 [95% CI, 8.64-15.19]). Women with epilepsy were also at a heightened risk for other adverse outcomes, including preeclampsia (adjusted OR, 1.59 [95% CI, 1.54-1.63]), preterm labor (adjusted OR, 1.54 [95% CI, 1.50-1.57]), and stillbirth (adjusted OR, 1.27 [95% CI, 1.17-1.38]), and had increased health care utilization, including an increased risk of cesarean delivery (adjusted OR, 1.40 [95% CI, 1.38-1.42]) and prolonged length of hospital stay (>6 days) among both women with cesarean deliveries (adjusted OR, 2.13 [95% CI, 2.03-2.23]) and women with vaginal deliveries (adjusted OR, 2.60 [95% CI, 2.41-2.80]). CONCLUSIONS AND RELEVANCE Findings suggest that women with epilepsy are at considerably heightened risk for many adverse outcomes during their delivery hospitalization, including a more than 10-fold increased risk of death, and that increased clinical attention is imperative for these pregnancies.
Transplanted Human Amniotic Epithelial Cells Secrete Paracrine Proangiogenic Cytokines in Rat Model of Myocardial Infarctio

Human amniotic epithelial cells (h-AECs) have been shown to differentiate into cardiomyocyte-like cells in vivo that can regenerate myocardial tissue and improve cardiac function in a rat model of myocardial infarction (MI). In this study, we investigated the paracrine factors released from h-AECs under hypoxic conditions to elucidate the possible mechanisms underlying this previously reported phenomenon of h-AEC-mediated cardiac repair. We used hypoxic cell culture conditions to simulate myocardial infarction in vitro. In comparison to normal conditions, we found that h-AECs secreted higher levels of several cytokines, including angiogenin (ANG), epidermal growth factor (EGF), interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1. To determine whether transplanted h-AECs express these proangiogenic cytokines in vivo, we ligated the coronary artery of rats to cause MI and injected either h-AECs or saline into the infarcted area. We found that the infarct and border zones of rat myocardium treated with h-AECs had higher expression levels of the human-origin cytokines ANG, EGF, IL-6, and MCP-1 compared to the tissues of saline-treated rats. In conclusion, h-AECs secreted proangiogenic cytokines in a rat model of MI, which may suggest that the paracrine effect by h-AECs could regenerate myocardial tissue and improve cardiac function.
Comparison of assays for antibodies to Encephalitozoon cuniculi in rabbits

Two indirect immunofluorescence (IIF) assays, two enzyme-linked immunosorbent assays (ELISAs)and the carbon immunoassay (CIA) for determination of antibodies to Encephalitozoon cuniculi were compared using 210 sera of rabbits, 135 of which originated from seven infected colonies, while 75 originated from four uninfected colonies. There was no evidence of a difference between the different assays with respect to the number of positive sera. There was a clear correlation between the quantitative response measured by IIF and CIA and the other assays, and between both IIF tests, while no such correlation was found in the quantitative response measured by ELISAs, which might be explained by the less quantitative nature of the ELISA. Therefore quantitative determination of antibodies to E. cuniculi should be performed by IIF and not by ELISA. The nosographic sensitivities N 1 and specificities N 2 of the assays were ≥ 0.94 and ≥ 0.97 respectively. Small differences in N 1 and N 2 between the assays, although not statistically significant, were responsible for differences in the calculated predictive values of a positive test and of a negative test. As expected, the magnitude of these differences depended on the fraction of positive sera sampled from a given colony. There was strong evidence of such a difference between the fraction of positive sera found in different colonies, but the sample size from some colonies was too small to allow any conclusion, whether this was due to differences in the prevalences of the infection in the colonies or something else. We conclude that any of the assays will be suitable for the routine health monitoring of laboratory rabbit colonies for E. cuniculi infection, as recommended by the Federation of European Laboratory Animal Science Associations.
A systematic review of performance-enhancing pharmacologicals and biotechnologies in the Army

Introduction In 2015, the Australian Army commissioned a systematic review to assess the evidence on effectiveness and safety of pharmacological and biotechnological products for cognitive enhancement specifically in Army personnel. Methods Searches for studies examining biotechnological and pharmacological products in Army populations were conducted in December 2015. Cochrane CENTRAL, MEDLINE, EMBASE, CINAHL and PsycINFO were searched without date or language restrictions. WHO’s International Clinical Trials Registry Platform and ClinicalTrials.gov were searched to identify ongoing trials. Studies meeting inclusion criteria were evaluated for risk of bias using Cochrane’s Risk of Bias tool. Due to heterogeneity of findings, meta-analysis could not be conducted. Findings were synthesised narratively and by vote-counting method. Results Sixteen pharmacological enhancement products were evaluated in 22 randomised controlled trials (RCTs), involving 1284 personnel. Only three of the studies were published since 2010. The interventions evaluated were varied, including supplements (eg, carbohydrate), stimulants (eg, caffeine) and hormones (eg, melatonin). Generally, caffeine provided an improvement in performance compared with placebo on 5/7 reported cognitive outcomes, followed by levothyroxine (four cognitive outcomes) and prazosin (three cognitive outcomes). Performance results were mixed (finding an improvement and no effect in comparison to placebo) for caffeine and melatonin on two outcomes. No evidence was found pertaining to biotechnological products. Studies rarely reported safety outcomes (eg, adverse events and addiction). Conclusion Findings from this review need to be interpreted with considerable caution. Future studies should include outcomes such as acute and long-term adverse events, and should evaluate cognitive performance using cognitive tests that are specific to the Army population.
Discrete vortex representation of magnetohydrodynamics.

We present an alternative approach to statistical analysis of an intermittent ideal MHD fluid in two dimensions, based on the hydrodynamical discrete vortex model applied to the Elsasser variables. The model contains negative temperature states which predict the formation of magnetic islands, but also includes a natural limit under which the equilibrium states revert to the familiar twin-vortex states predicted by hydrodynamical turbulence theories. Numerical dynamical calculations yield equilibrium spectra in agreement with the theoretical predictions.
Direct non-medical and indirect costs for families with children with congenital cardiac defects in Germany: a survey from a university centre

Abstract Introduction Parents of children with congenital cardiac disease suffer from psychological stress and financial burdens. These costs have not yet been quantified. Materials and methods In cooperation with paediatricians, social workers, and parents, a questionnaire was devised to calculate direct non-medical and indirect costs. Direct non-medical costs include all costs not directly related to medical services such as transportation. Indirect costs include lost productivity measured in lost income from wages. Parents were retrospectively queried on costs and refunds incurred during the child’s first and sixth year of life. The questionnaire was sent out to 198 families with children born between 1980 and 2000. Costs were adjusted for inflation to the year 2006. Children were stratified into five groups according to the severity of their current health status. Results Fifty-four families responded and could be included into the analysis (27.7%). Depending on severity, total direct non-medical and indirect costs in the first year of life ranged between an average of €1654 in children with no or mild (remaining) cardiac defects and an average €2881 in children with clinically significant (residual/remaining) findings. Mean expenses in the sixth year of life were as low as €562 (no or mild (remaining) cardiac defects) and as high as €5213 (potentially life-threatening findings). At both points in time, the highest costs were lost income and transportation; and day care/ babysitting for siblings was third. Discussion Families of children with congenital cardiac disease and major sequelae face direct non-medical and indirect costs adding up to €3000 per year on average. We should consider compensating families from low socioeconomic backgrounds to minimise under-use of non-medical services of assistance for their children.