Miracle-dz/UniFAR-FTUs huggingface dataset:
Understanding Digital Marketing Adoption in India: Integrated by Technology Acceptance Model (TAM) and Theory of Planned Behaviour (TPB) Framework

: Start-ups although small, are great contributors in any economy. Marketing being essential function for their survival, this study aims to examine the use of digital marketing by start-up companies in India using two models TPB and TAM. The Proposed conceptual theoretical model is being tested empirically using a data comprised of 282 founders/owners of start-up companies, collected through structured questionnaire. Conﬁrmatory factor analysis (CFA) is carried out for model ﬁtness and structural equation modeling for path regression analysis. The results of the study suggest that perceived usefulness of digital marketing, attitude towards digital marketing, and perceived behavioral control of the founders/owners of startups signiﬁcantly positively impact their intentions to use digital marketing and digital marketing adoption. The suggestions will help start-ups for adoption of digital marketing for their businesses and will give some meaningful in sights to the strategy formulation for marketing by start-ups. This study makes valuable contribution towards the theoretical aspect of digital marketing, speciﬁcally with respect to start-ups.
MicroRNA-506-3p inhibits ovarian cancer metastasis by down-regulating the expression of EZH2

Objective: To investigate the role of miR-506-3p in ovarian cancer (OvCa) metastasis. Methods: We overexpressed miR-506-3p in OvCa cells, and cell migration and invasion capacities were assessed in vitro using Transwell assays and wound healing assay. EZH2 is a target of miR-506-3p. We overexpressed and knocked down EZH2 in SKOV3 cells, and assessed its impact on cell migration and invasion. The orthotopic OvCa mouse models were conducted to confirm the role of miR-506-3p in OvCa metastasis. Results: In this research, we found that miR-506-3p reduced EZH2 expression and obviously suppressed the cell migration and invasion in ovarian cancer (OvCa). Moreover, the knockout of EZH2 mimicked the effect of miR-506-3p on invasion and migration, whereas EZH2 overexpression rescued the inhibitory effect of miR-506-3p. The orthotopic OvCa mouse models and clinical cases also confirmed the negative correlation between miR-506-3p and EZH2 in OvCa Conclusions: MiR-506-3p can suppress cell migration and invasion by targeting EZH2 in OvCa. Our study provides evidence supporting miR-506-3p-based therapy in OvCa.
Acrylonitrile and Pullulan Based Nanofiber Mats as Easily Accessible Scaffolds for 3D Skin Cell Models Containing Primary Cells

(1) Background: Three-dimensional (3D) collagen I-based skin models are commonly used in drug development and substance testing but have major drawbacks such as batch-to-batch variations and ethical concerns. Recently, synthetic nanofibrous scaffolds created by electrospinning have received increasing interest as potential alternatives due to their morphological similarities to native collagen fibrils in size and orientation. The overall objective of this proof-of-concept study was to demonstrate the suitability of two synthetic polymers in creating electrospun scaffolds for 3D skin cell models. (2) Methods: Electrospun nanofiber mats were produced with (i) poly(acrylonitrile-co-methyl acrylate) (P(AN-MA)) and (ii) a blend of pullulan (Pul), poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAA) (Pul/PVA/PAA) and characterized by scanning electron microscopy (SEM) and diffuse reflectance infrared Fourier transform (DRIFT) spectra. Primary skin fibroblasts and keratinocytes were seeded onto the nanofiber mats and analyzed for phenotypic characteristics (phalloidin staining), viability (Presto Blue HS assay), proliferation (Ki-67 staining), distribution (H/E staining), responsiveness to biological stimuli (qPCR), and formation of skin-like structures (H/E staining). (3) Results: P(AN-MA) mats were more loosely packed than the Pul/PVA/PAA mats, concomitant with larger fiber diameter (340 nm ± 120 nm vs. 250 nm ± 120 nm, p < 0.0001). After sterilization and exposure to cell culture media for 28 days, P(AN-MA) mats showed significant adsorption of fetal calf serum (FCS) from the media into the fibers (DRIFT spectra) and increased fiber diameter (590 nm ± 290 nm, p < 0.0001). Skin fibroblasts were viable over time on both nanofiber mats, but suitable cell infiltration only occurred in the P(AN-MA) nanofiber mats. On P(AN-MA) mats, fibroblasts showed their characteristic spindle-like shape, produced a dermis-like structure, and responded well to TGFβ stimulation, with a significant increase in the mRNA expression of PAI1, COL1A1, and αSMA (all p < 0.05). Primary keratinocytes seeded on top of the dermis equivalent proliferated and formed a stratified epidermis-like structure. (4) Conclusion: P(AN-MA) and Pul/PVA/PAA are both biocompatible materials suitable for nanofiber mat production. P(AN-MA) mats hold greater potential as future 3D skin models due to enhanced cell compatibility (i.e., adsorption of FCS proteins), cell infiltration (i.e., increased pore size due to swelling behavior), and cell phenotype preservation. Thus, our proof-of-concept study shows an easy and robust process of producing electrospun scaffolds for 3D skin cell models made of P(AN-MA) nanofibers without the need for bioactive molecule attachments.
Effect of Stirring Speed on the Formation and Characteristic of Alginate Microspheres via Gelation/ Emulsification Method

Alginate microspheres are used for controlled drug delivery system; however, the formation and size control of alginate microspheres is necessary for these systems to be effective. Therefore, the influence of stirring speed on the characteristic of alginate microspheres (AMs) via emulsification/gelation method was evaluated. Alginate solution was emulsified into liquid paraffin oil to form water in oil emulsion and followed by cross-linked with Ca2+ ions. The shape and surface characteristics of AMs were determined by scanning electron microscope (SEM). Morphological observation shows that at lower stirring speed, the alginate particles were irregularly shaped with a rough surface. Whereas, increasing stirring speed resulted in spherical microspheres with smoother surface. Particle size analysis by laser diffraction method showed a decreased in mean particle size and more homogeneous distribution as the stirring speed increased. The mean particle size of AMs was found to be in the range of 28.5-69.6 μm. Fourier transform infrared (FTIR) analysis shows that there was no shifting in peak positions in the transmittance spectrum of AMs. This study suggested that the formation of AMs can be synthesis via emulsification/gelation method and the size of the AMs can be tailor by varying the stirring speed.
Simulation of Cardiac Flow under the Septal Defect Based on Lattice Boltzmann Method

In this paper, the lattice Boltzmann method was used to simulate the cardiac flow in children with aseptal defect. The inner wall model of the heart was reconstructed from 210 computed tomography scans. By simulating and comparing the cardiac flow field, the pressure field, the blood oxygen content, and the distribution of entropy generation before and after an operation, the effects of septal defect on pulmonary hypertension(PH), cyanosis, and heart load were analyzed in detail. It is found that the atrial septal defect(ASD) of the child we analyzed had a great influence on the blood oxygen content in the pulmonary artery, which leads to lower efficiency of oxygen binding in the lungs and increases the burden on the heart. At the same time, it also significantly enhanced the entropy generation rate of the cardiac flow, which also leads to a higher heart load. However, the main cause of PH is not ASD, but ventricular septal defect (VSD). Meanwhile, it significantly reduced the blood oxygen content in the brachiocephalic trunk, but rarely affects the blood oxygen contents in the downstream left common carotid artery, left subclavian artery, and descending aorta are not significantly affected by VSD. It causes severe cyanosis on the face and lips.
The impact of macroeconomic indicators on the business performance of financial institutions in the Republic of Serbia: Panel data analysis

This paper aims to estimate the impact of macroeconomic indicators (gross domestic product-GDP, inflation rate and industrial production index) on liquidity, profitability and solvency of financial institutions in the Republic of Serbia. The research is based on applying a dynamic GMM panel model, while the results of the application of static panel models were analyzed as the control results. The research results support the assumption that the growth of GDP and inflation rates affects the increase of financial institutions' profitability. Also, the estimation results implicate that the growth of GDP and the inflation rate is linked with the reduction of financial institutions' liquidity, while the growth of industrial production rate affects its increase. Finally, the results of the study indicate that GDP growth has an influence on the rise of financial sector solvency. This comparative analysis using panel data models is relevant to a broad range of researchers and policymakers interested in macroeconomic relations and the financial sector.
Coping with complexity in the COVID pandemic: An exploratory study of intensive care units

Although the COVID pandemic has challenged the resilience of health services in general, this impact has been most visible in intensive care units (ICUs). This paper presents an exploratory study of how ICUs in Brazil have coped with the complexity stemming from the pandemic. Five guidelines for coping with complexity were adopted as analytical framework. The guidelines were concerned with slack resources, diversity of perspectives, visibility, work‐as‐done, and unintended consequences. There were three main sources of data: (i) a survey with respondents from 33 ICUs, which indicated their agreement with 23 statements related to the use of the complexity guidelines; (ii) semistructured interviews with seven survey respondents and two public health officials; and (iii) 20 h of observations of the meetings of a municipal bed management committee. Seventy resilience practices were identified from these data sources. Most of these practices (n = 30) were related to the guideline on slack resources, which were commonly obtained from other hospital units. As for the survey data, the statement related to the availability of extra or standby human resources obtained the lowest score, reinforcing the key role of slack resources. Five lessons learned for coping with complexity in ICUs were drawn from our data; one lesson for each guideline. Furthermore, the survey questionnaire is a potential ICU assessment tool, which can be adapted to other health services.
Diversity in CLIL as experienced by Finnish CLIL teachers and students: matters of equality and equity

ABSTRACT This article focuses on how Finnish CLIL teachers and students orient to and experience diversity in CLIL. The data consist of teacher and student interviews that were analysed using qualitative content analysis to identify recurrent themes with regard to diversity. The findings indicate that the theme of equality in the sense of ‘the same for all’ in both teaching, assessing and homework was readily brought up by both groups, reflecting the ethos of equality prevalent in Finnish education. Equity, however, was not similarly highlighted even though it is a guiding principle alongside equality in the Finnish Core Curriculum for Basic Education. Teachers were found reluctant to topicalise diversity, at least in the form of explicit differentiation. This applied especially to academic skills, with students’ different linguistic skills more readily addressed. Both teacher and student interviews construct CLIL students as high-achievers in comparison to peers in regular classrooms. The students, however, also criticised being treated as a homogenous group and expressed wishes for personalised support. In sum, the findings show tensions between maintaining equality and securing equity in that adherence to the same type of education for all may render invisible the varying competences, ways of learning and needs for support.
Enhancing Urban Biodiversity: A Theory of Planned Behavior Study of the Factors Influencing Real Estate Actors’ Intention to Use Nature-Inclusive Design and Construction Concepts

This paper presents the results of an exploration into the adoption of biodiversity-friendly practices by the real estate sector, by researching which factors determine companies’ intentions to use nature-inclusive design and construction concepts (NID). NID represents practices in which nature and building are inextricably linked when (re)designing building projects. We applied the Theory of Planned Behavior (TPB), a well-known framework for studying behavior. A telephone survey was carried out among 103 employees at different types of companies in the real estate sector. The findings showed that attitude, social norms, and perceived behavioral control are all significant explanatory variables for the intention of using NID. Perceived behavioral control is the strongest predictor. In addition, interest in NID strengthens the predictive value of perceived behavioral control. The empirical findings in this study serve as a first attempt to provide insights into the determinants of behavior in favor of using NID and, by extension, looking for drivers for change. The study was carried out in the Netherlands, but the results may be applicable or interesting to other countries as well when looking for opportunities to enhance biodiversity in urban areas or considering how the real estate sector could give substance to their vital role in spatial developments.
Agri-Food Industry Waste as Resource of Chemicals: The Role of Membrane Technology in Their Sustainable Recycling

The agri-food sector generates substantial quantities of waste material on farm and during the processing of these commodities, creating serious social and environmental problems. However, these wastes can be resources of raw material for the production of valuable chemicals with applications in various industrial sectors (e.g., food ingredients, nutraceuticals, bioderived fine chemicals, biofuels etc.). The recovery, purification and biotransformation of agri-food waste phytochemicals from this microbial spoilage-prone, complex agri-food waste material, requires appropriate fast pre-treatment and integration of various processes. This review provides a brief summary and discussion of the unique advantages and the importance of membrane technology in sustainable recycling of phytochemicals from some of the main agri-food sectors. Membrane-based pressure -driven processes present several advantages for the recovery of labile compounds from dilute streams. For example, they are clean technologies that can operate at low temperature (20–60 °C), have low energy requirements, there is no need for additional chemicals, can be quite automated and electrifiable, and have low space requirements. Based on their permselective properties based on size-, shape-, and charge-exclusion mechanisms, membrane-based separation processes have unpaired efficiency in fractionating biological components while presenting their properties. Pressure-driven membrane processes, such as microfiltration (MF), ultrafiltration (UF) and nanofiltration (NF), as well as other advanced membrane-based processes such as membrane bioreactors (MBR), membrane emulsification (ME) and membrane distillation (MD), are presented. The integration of various membrane technologies from the initial recovery of these phytochemicals (MF, UF, NF) to the final formulation (by ME) of commercial products is described. A good example of an extensively studied agri-food stream is the olive processing industry, where many different alternatives have been suggested for the recovery of biophenols and final product fabrication. Membrane process integration will deliver in the near future mature technologies for the efficient treatment of these streams in larger scales, with direct impact on the environmental protection and society (production of compounds with positive health effects, new job creation, etc.). It is expected that integration of these technologies will have substantial impact on future bio-based societies over forthcoming decades and change the way that these chemicals are currently produced, moving from petrochemical-based linear product fabrication to a sustainable circular product design based in agri-food waste biomass.
Equity and Social Justice in Research Practice Partnerships in the United States

Research–practice partnerships (RPPs) have grown rapidly in the last decade in the United States to challenge traditional notions of education research by emphasizing the importance of researchers and practitioners working together in a spirit of mutuality to develop research questions, collect data, implement interventions, and analyze and use findings. RPP scholarship in the United States has historically advocated for the need to pay more focused attention to issues of equity and justice. To address that need, this literature review examined how RPPs in the United States have addressed equity and justice in their work. Based on five dimensions of equity and justice that could be observed within the 149 examples of RPP work we reviewed, we identified 17 exemplar projects that explicitly and effectively forefront equity and justice in RPPs, what we call equity-focused. Implications suggest that researchers and practitioners who have initiated equity-orientated RPPs may reflect on the partnerships’ existing strengths, specifically related to the five interconnected features that characterize equity-focused RPPs, to sustain and advance equity and justice through RPPs.
Collaborative Research on Mouth Shape and Lyrics in Singing Practice Based on Image Processing

Image processing is a mainstream processing method. When people enjoy artists' singing videos, there will be a problem that the subtitles of the lyrics are out of sync with the singer's mouth shape. This problem needs to be solved using image processing technology, letting the computer realize lip-reading recognition function and correct the mouth shape and lyrics subtitles in the image according to the extracted lip-reading data, so that the mouth shape and lyrics in singing practice can be synchronized. Lip-reading information can effectively improve the accuracy of language cognition, save part of capital and manpower investment, and make viewers get a good audio-visual interactive experience. The results show the following: (1) After the UI test, the system user interface function design is reasonable and there is no bad BUG. We can find that the average processing time of each frame is 628 ms, the system performance evaluation is good, and the success rate can be as high as 98.80%. 0.36724 s is the average time for each step when the system processes the image. (2) The human image can basically identify the portrait area and lip area from various angles. (3) Compared with DCT and DWT, the recognition rate of the two cascade lip region feature extraction methods is improved by nearly 10%, and the feature vector dimension is reduced by nearly 65%. (4) Classify the mouth shape more finely and optimize the image of the tester's mouth shape to make the mouth shape closer to the standard mouth shape. (5) After systematic correction of mouth shape and subtitles, the success rate is higher than 90%. Finally, we can find that the running effect is good and the method has achieved high results, which can carry out the details of the next optimization work.
LINC00630 promotes cholangiocarcinoma cell proliferation, migration and invasion by mediating the miR-199a/FGF7 axis

Cholangiocarcinoma (CCA) is a type of cancer with a relatively low morbidity, but poor prognosis. Aberrant long non-coding RNA (lncRNA) expression has been observed in the pathological development of CCA. In the present study, lncRNA long intergenic non-protein coding RNA 630 (LINC00630) was found to be significantly upregulated in CCA tissues and cultured cells. LINC00630 expression was positively associated with histological differentiation, TNM stage and lymph node invasion. Short hairpin RNA (sh)-LINC00630 transfection could effectively decrease CCA cell proliferation, migration and invasion. Further investigations found that LINC00630 could interact with microRNA (miR)-199a, which specifically targeted fibroblast growth factor 7 (FGF7) for degradation. FGF7 overexpression restored the sh-LINC00630 transfection-induced decrease in CCA cell proliferation, migration and invasion. In conclusion, LINC00630 significantly promoted CCA cell proliferation, migration and invasion by upregulating FGF7 through miR-199a sponging.
Identification, Culture and Targeting of Cancer Stem Cells

Chemoresistance, tumor progression, and metastasis are features that are frequently seen in cancer that have been associated with cancer stem cells (CSCs). These cells are a promising target in the future of cancer therapy but remain largely unknown. Deregulation of pathways that govern stemness in non-tumorigenic stem cells (SCs), such as Notch, Wnt, and Hedgehog pathways, has been described in CSC pathogenesis, but it is necessary to conduct further studies to discover potential new therapeutic targets. In addition, some markers for the identification and characterization of CSCs have been suggested, but the search for specific CSC markers in many cancer types is still under development. In addition, methods for CSC cultivation are also under development, with great heterogeneity existing in the protocols used. This review focuses on the most recent aspects of the identification, characterization, cultivation, and targeting of human CSCs, highlighting the advances achieved in the clinical implementation of therapies targeting CSCs and remarking those potential areas where more research is still required.
STEPPING CHARACTERISTIC OF ULTRASONIC MOTOR AND ITS STEPPING-POSITIONING CONTROL

Ultrasonic motor is difierent from traditi- onal electromagnetic motor and it is driven bv friction force.It is characterized by rapidly dynamic perfor- mance and high resolution.Based on its character,this paper introduces a precise position control metho- d.Firstly,the paper points out the essentials of high resolution and stepping characteristic of ultrasonic motor in theory and experiment.Next,based on this characteristic of the motor,the paper discusses high precise position control strategy named stepping- position control method and the factors that influence position precision are analyzed.By the stepping- position control method,high precise position control (0.010°) have been realized by the experimental hybrid transducer type ultrasonic motor,which demonstrates its potential for driving high precise mechanical system,such as MEMS.
“In México, I was someone, but here I am a nobody:” an immigrant mother and daughter moving beyond love to facilitate new ways of being

Abstract In this article, we present parallel narratives of an immigrant youth and her mother who have had to maneuver continual and abrupt interruptions in family cohesiveness and other daily experiences due to anti-immigrant policies and the materialization of being cast beyond love. We highlight how they created spaces of self-transformational love and coalitional love to resist measures of exclusion and redraw how they participated in a divided world. We also argue how educators must encourage these spaces of love and work against practices that contribute to the alienation and suppression of immigrant students and their families. Rather, educators must put a human face to these human struggles and break free from any pretense that this work should solely occur outside the bounds of a school’s borders.