Miracle-dz/UniFAR-FTUs huggingface dataset:
Soil moisture gradients and climate change: predicting growth of a critical boreal tree species

Understanding the complex relationships among climate, tree growth, and water availability is key for predicting the performance of environmentally and economically salient tree species like Pinus banksiana Lamb. Ecologically, P. banksiana occupies the extreme habitats of soil moisture gradient, from very sandy dry soils to waterlogged bogs. However, little is known about how its growth may be affected by future climate in these two habitats. We assessed the effect of climatic variability on the growth of this species under different moisture conditions (sandy dry soils and bogs). Trees in the bog site had the highest growth rates. Individuals in all sites responded positively to increased spring temperature, whereas those in the bog site showed the highest response to increased summer moisture. However, in dry years, growth response in the bog site declined by 17%, whereas in the two drier sites, growth declined between 1% and 9.6%, equalizing growth rates across sites. Further, the decline in growth associated with drier summers eliminated the benefits of warmer springs at the bog site. Sites near bogs are currently associated with high growth performance and are commonly planted with this species. Yet, under the projected climate for the region, trees growing in these sites will likely lose their advantage.
Communities and regularities in the behavior of investment fund managers

Significance This paper relies on a unique database of fund managers’ holdings to map their behavior across asset classes. We unravel the existence of stable and persistent communities. This paper characterizes three different main behavioral attitudes: conservative, reactive, and proactive. Macroeconomic shocks temporarily perturb the configuration of the system, altering the differences between communities. This paper represents a significant step forward in understanding how heuristics, attitudes, and routines shape the behavior of expert investors. It opens a research trajectory in the analysis of behavioral interdependencies in financial markets. We analyze a large microlevel dataset on the full daily portfolio holdings and exposures of 22 complex investment funds to shed light on the behavior of professional investment fund managers. We introduce a set of quantitative attributes that capture essential distinctive features of manager allocation strategies and behaviors. These characteristics include turnover, attitude toward hedging, portfolio concentration, and reaction to external events, such as changes in market conditions and flows of funds. We find the existence and stability of three main investment attitude profiles: conservative, reactive, and proactive. The conservative profile shows low turnover and resilience against external shocks; the reactive one is more prone to respond to market condition changes; and members of the proactive profile frequently adjust their portfolio allocations, but their behavior is less affected by market conditions. We find that exogenous shocks temporarily alter this configuration, but communities return to their original state once these external shocks have been absorbed and their effects vanish.
Overcoming Barriers to the Community Acceptance of Wind Energy: Lessons Learnt from a Comparative Analysis of Best Practice Cases across Europe

Empirical evidence has shown that local community opposition is one of the key obstacles for new wind energy development. Consequently, the community acceptance of renewables, such as wind energy, has become a crux for Europe in both achieving and going beyond its renewable energy targets. Significant academic literature has already been devoted to conceptualising the community acceptance of wind energy. This article builds on the existing research by showcasing how regions and municipalities across Europe have successfully and effectively been able to overcome barriers to community acceptance. In doing so, 10 best practice case studies across six European countries have been carefully identified and investigated. The results of individual assessment of these different cases, each of which employ different types of measures/approaches, are comparatively analysed in order to identify the key success factors (drivers) for achieving community acceptance of wind energy in Europe. The identification of the success factors serves to start paving the way for the transfer of these measures/approaches to other municipalities and regions across Europe, particularly those who may encounter similar barriers of community acceptance of wind energy. Thus, our findings deliver to policy makers and developers a number of lessons learnt on how to organise future actions by proposing ways their activities can enhance community acceptance.
Regenerative Endodontic Procedures Using Contemporary Endodontic Materials

Calcium hydroxide apexification and Mineral Trioxide Aggregate (MTA) apexification are classical treatments for necrotic immature permanent teeth. The first tend to fail for lack of compliance given the high number of sessions needed; the second has technical difficulties such as material manipulation and overfilling. With both techniques, the root development is interrupted leaving the tooth with a fragile root structure, a poor crown-to-root ratio, periodontal breakdown, and high risk of fracture, compromising long-term prognosis of the tooth. New scientific literature has described a procedure that allows complete root development of these specific teeth. This regenerative endodontic procedure (REP) proposes the use of a combination of antimicrobials and irrigants, no canal walls instrumentation, induced apical bleeding to form a blood clot and a tight seal into the root canal to promote healing. MTA is the most used material to perform this seal, but updated guidelines advise the use of other bioactive endodontic cements that incorporate calcium and silicate in their compositions. They share most of their characteristics with MTA but claim to have fewer drawbacks with regards to manipulation and aesthetics. The purpose of the present article is to review pertinent literature and to describe the clinical procedures protocol with its variations, and their clinical application.
Central and Peripheral Changes in FOS Expression in Schizophrenia Based on Genome-Wide Gene Expression

Schizophrenia is a chronic, debilitating neuropsychiatric disorder. Multiple transcriptomic gene expression profiling analysis has been used to identify schizophrenia-associated genes, unravel disease-associated biomarkers, and predict clinical outcomes. We aimed to identify gene expression regulation, underlying pathways, and their roles in schizophrenia pathogenesis. We searched the Gene Expression Omnibus (GEO) database for microarray studies of fibroblasts, lymphoblasts, and post-mortem brains of schizophrenia patients. Our analysis demonstrated high FOS expression in non-neural peripheral samples and low FOS expression in brain tissues of schizophrenia patients compared with healthy controls. FOS exhibited predictive value for schizophrenia patients in these datasets. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed that “amphetamine addiction” was among the top 10 significantly enriched KEGG pathways. FOS and FOSB, which are implicated in the amphetamine addiction pathway, were up-regulated in schizophrenia fibroblast samples. Protein–protein interaction (PPI) network analysis revealed that proteins closely interacting with FOS-encoded protein were also involved in the amphetamine addiction pathway. Pearson correlation test indicated that FOS showed positive correlation with genes in the amphetamine pathway. The results revealed that FOS was acceptable as a biomarker for schizophrenia and may be involved in schizophrenia pathogenesis.
Effect of acetylsalicylic acid intake on platelet derived microvesicles in healthy subjects

Abstract Platelet-derived microvesicles (pMVs) are released from platelets in physiological and pathological conditions and exhibit a wide range of prothrombotic, antithrombotic, proatherogenic, and pro-inflammatory properties. Antiplatelet agents, such as acetylsalicylic acid (ASA), are widely used for the prevention and treatment of vascular diseases, but their impact on pMV release remains poorly understood and contradictory mainly because of discrepancies in the methodology and lack of well-standardized MV assessment protocols. The present study investigated the effects of ASA not only on total pMV release but also on their phenotypes defined using the surface expression of pro-inflammatory (CD40L, CD62P, CD31) and procoagulant (PS, PAC-1) markers in healthy subjects. Fifty healthy volunteers were enrolled in the study and received a daily dose of 150 mg ASA for 3 consecutive days. Circulating pMVs were characterized and quantified before and after the intervention period using flow cytometry. Serum levels of thromboxane B2 (TXB2) and whole blood impedance platelet aggregation under arachidonic acid (AA) stimulation were also investigated to assess ASA compliance. In general, ASA did not effect pMV numbers in healthy subjects despite its effective inhibition of platelet aggregation Moreover, in premenopausal women, we noticed an increase in the number of pMVs. Further studies are needed to assess whether dose modification of ASA or combinations or changes in antiplatelet therapy would reduce pMV formation, especially in patients with cardiovascular risk factors.
An Intelligent Coupling 3-Grade Fuzzy Comprehensive Evaluation Approach With AHP for Selection of Levitation Controller of Maglev Trains

During recent years, maglev transportation has made great progress, and as a result, many intelligent levitation control algorithms have emerged. However, enterprises often find it difficult to make a choice when faced with the selection of a controller. The main reason is that the performance evaluation of control algorithms is a complex, multiple-criteria, multifactor coupling problem that cannot be represented by a precise mathematic model. In this paper, a novel artificial intelligent evaluation method for the selection of a levitation controller is developed based on a 3-grade fuzzy method and analytic hierarchy process (AHP). Three kinds of intelligent levitation control algorithms are applied to a full-size test maglev train to collect experimental results with real data. The proposed artificial intelligence method to develop a 3-grade fuzzy multicriteria approach is used to select the best levitation controller for the maglev train. This method can then provide information consultation services to maglev train firms. To the best of our knowledge, for maglev trains, this is the first intelligent evaluation approach with real experimental data. The proposed method can also be applied to other information consultation and decision making systems with appropriate modifications.
Summary and Trends of the Russian Gonococcal Antimicrobial Surveillance Programme, 2005 to 2016

The Russian Gonococcal Antimicrobial Surveillance Programme (RU-GASP) was established in 2004 and operated continuously during the years from 2005 to 2016. The aims of this study were to summarize the RU-GASP results over this 12-year period and evaluate the trends in Neisseria gonorrhoeae antimicrobial resistance in Russia. ABSTRACT The Russian Gonococcal Antimicrobial Surveillance Programme (RU-GASP) was established in 2004 and operated continuously during the years from 2005 to 2016. The aims of this study were to summarize the RU-GASP results over this 12-year period and evaluate the trends in Neisseria gonorrhoeae antimicrobial resistance in Russia. In total, 5,038 verified N. gonorrhoeae isolates from 40 participating regions were tested for susceptibility to six antimicrobials via an agar dilution method. DNA loci involved in antimicrobial resistance were identified via minisequencing or DNA microarray techniques. From 2005 to 2016, increasing susceptibility to penicillin G (from 22.6% to 63.0%), tetracycline (from 34.8% to 53.0%), and ciprofloxacin (from 50.6% to 68.6%) was observed, but resistance to these drugs remained high. The proportions of isolates nonsusceptible to azithromycin and spectinomycin peaked in 2011 and decreased thereafter. Of the isolates, only 6 and 23 were identified as nonsusceptible to ceftriaxone according to the CLSI definitions and EUCAST breakpoint (0.57% of the total population), respectively. Comparison of N. gonorrhoeae antimicrobial resistance genetic determinants in 2005 versus those in 2016 showed a significant decrease in the number of isolates carrying chromosomal mutations. The proportion of isolates with wild-type genotypes increased from 11.7% in 2005 to 30.3% in 2016. Thus, the RU-GASP can be considered a successful gonorrhea surveillance program, and the current state of N. gonorrhoeae antimicrobial resistance in Russia is less serious than that in other WHO GASP regions.
Strangers in a Strange Land: Relations Between Perceptions of Others' Values and Both Civic Engagement and Cultural Estrangement

Healthy democracies require civic engagement (e.g., voting) from their citizens. Past research has suggested that civic engagement is positively associated with self-transcendence values of care and concern for the welfare of others, and negatively associated with self-enhancement values of self-interest, dominance, and personal success. However, research has yet to address whether people's perceptions of others' values are related to civic engagement. Across three studies with nationally representative samples in the UK and US (Ns ≥ 1,000), we explored how civic engagement relates to (a) perceptions of national values, (b) perceptions of the values of one's typical compatriot, and (c) perceptions of the values encouraged by social and cultural institutions. Study 1 showed that the tendency for British citizens to perceive British culture as valuing self-transcendence was associated with an increased likelihood of voting in the 2015 general election. These findings were replicated for “a typical British person” (Study 2) and “a typical American person” (Study 3); Studies 2 and 3 also found that perceived self-enhancement values of typical compatriots were negatively correlated with reported voting. We also examined how perceptions of others' values relate to cultural estrangement—the feeling of not fitting in one's culture or of being atypical. Like civic engagement, those who perceived less self-transcendence and more self-enhancement in their culture felt more culturally estranged. Mediation analyses in Studies 2 and 3 revealed that estrangement helped to explain the relationship between perceptions of others' values and voting. In sum, the extent to which Brits and Americans perceive that self-transcendence values are strongly held by other citizens is associated with feeling less estranged and with reports of being more civically engaged. In contrast, the perception that these targets hold or promote self-enhancement values is positively associated with feelings of estrangement, to the detriment of civic engagement. Implications for future research and democratic processes are discussed.
Immunohistochemical Expression of Autophagy-Related Proteins in Advanced Tubular Gastric Adenocarcinomas and Its Implications

In neoplastic conditions, autophagy may act as a tumor suppressor avoiding the accumulation of damaged proteins and organelles or as a mechanism of cell survival promoting the tumor growth. Although ultrastructural analysis has been considered the traditional method to identify autophagy, some proteins such as microtubule-associated protein 1 light chain 3 (LC3A/B), Beclin-1 and activating molecule in Beclin-1-regulated autophagy protein-1 (AMBRA-1) may be considered as markers of autophagy-assisted cancerogenesis. Herein, we analyzed a cohort of advanced tubular gastric adenocarcinomas by the abovementioned immunohistochemical antisera; through immunohistochemistry, autophagy (A-IHC) is diagnosed when at least two out of the three proteins are positive in the samples. Immunostaining for LC3A/B, Beclin-1, and AMBRA-1 was exclusively found in neoplastic elements, but not in surrounding stromal cells. In detail, LC3A/B and Beclin 1 were expressed both in the cytoplasm and in the nucleus of the cancer cells, while AMBRA-1 was preferentially localized in the nucleus, mainly in high grade cases. LC3A/B, Beclin 1, and AMBRA-1 expression were positive in 18 (56.2%), 17 (53.1%), and 12 (37.5%) cases, respectively. The sensibility and specificity of LC3A/B and Beclin-1 ranged from 81.25% to 93.75%, with high efficiency (90.63%) for Beclin-1. Moreover, the ultrastructural autophagic index (AI) was also available in all cases. All high-grade cases documented a Ki-67 labelling index (LI) ≥ 30%, even if three low-grade cases revealed a high Ki-67 value; p53 positivity was encountered in 21/32 (65.62%) of cases, independently of the tumor grade. A statistically significant correlation among A-IHC and clinicopathological parameters such as grade, stage, clinical course, Ki-67 LI and AI was revealed. Univariate analysis documented a significant p-value for the same autophagic variables. Additionally, multivariate survival analysis identified the grade, AI and A-IHC as independent significant variables. Finally, the overall survival curves of all cases of gastric tubular adenocarcinoma were greatly dependent on A-IHC. Therefore, we suggest that autophagic-related proteins might be considered promising predictive prognostic factors of advanced gastric cancer. Further investigations may be required to determine whether new targeted therapies should be addressed to autophagy-related proteins.
Immunostaining characteristics of irisin in benign and malignant renal cancers

ABSTRACT We investigated the expression of irisin in renal cancers using immunocytochemistry. Irisin has been reported to exhibit anticancer properties. The study groups consisted of 22 cases each of control renal tissue, oncocytoma, chromophobe renal cell carcinoma (RCC), clear cell RCC (Fuhrman nuclear grades 1, 2, 3 and 4) and papillary RCC. We evaluated 10 slides for each of 176 cases. Slides were immunostained for irisin and histoscores were calculated for the prevalence and strength of immunostaining. Fuhrman nuclear grade 1, 2, 3 clear cell RCC and papillary RCC exhibited no irisin immunoreactivity. Irisin immunoreactivity was observed in some Fuhrman nuclear grade 4 RCCs. We found a significant decrease in irisin staining in chromophobe RCC compared to the control. Immunoreactivity in the oncocytoma tissue was comparable to the control group. Irisin immunoreactivity in chromophobe RCC decreased and no immunoreactivity was observed in Fuhrman nuclear grade 1, 2, 3 clear cell RCC and papillary RCC. Immunistochemical screening of irisin in renal oncocytomas and renal cancers may be useful for differential diagnosis.
Disorder in milk proteins: adipophilin and TIP47, important constituents of the milk fat globule membrane

Abstract Milk fat globules (MFGs), which are secreted by the epithelial cells of the lactating mammary glands, account for the most of the nutritional value of milk. They are enveloped by the milk fat globule membrane (MFGM), a complex structure consisting of three phospholipid membrane monolayers and containing various lipids. Depending on the origin of milk, specific proteins accounts for 5–70% of the MFGM mass. Proteome of MFGMs includes hundreds of proteins, with nine major components being adipophilin, butyrophilin, cluster of differentiation 36, fatty acid binding protein, lactadherin, mucin 1, mucin 15, tail-interacting protein 47 (TIP47), and xanthine oxidoreductase. Two of the MFGM components, adipophilin and TIP47, belong to the five-member perilipin family of lipid droplet proteins. Adipophilin is involved in the formation of cytoplasmic lipid droplets and secretion of MFGs. This protein is also related to the formation of other lipid droplets that exist in most cell types, playing an important role in the transport of lipids from ER to the surface of lipid droplets. TIP47 acts as a cytoplasmic sorting factor for mannose 6-phosphate receptors and is recruited to the MFGM. Therefore, both adipophilin and TIP47 are moonlighting proteins, each possessing several unrelated functions. This review focuses on the main functions and specific structural features of adipophilin and TIP47, analyzes similarities and differences of these proteins among different species, and describes these proteins in the context of other members of the perilipin family. Communicated by Ramaswamy H. Sarma
Diagnostic and prognostic value of CEP55 in clear cell renal cell carcinoma as determined by bioinformatics analysis

Clear cell renal cell carcinoma (ccRCC) is one of the most common types of malignant adult kidney tumor. Tumor recurrence and metastasis is the primary cause of cancer-associated mortality in patients with ccRCC. Therefore, identification of efficient diagnostic and prognostic molecular markers may improve survival times. The GSE46699, GSE36895, GSE53000 and GSE53757 gene datasets were downloaded from the Gene Expression Omnibus database and contained 196 ccRCC samples and 164 adjacent normal kidney samples. Bioinformatics analysis was used to integrate the four microarray datasets to identify and analyze differentially expressed genes. Functional analysis revealed that there were 12 genes associated with cancer, based on the tumor-associated gene database. Erb-B2 receptor tyrosine kinase 4, centrosomal protein 55 (CEP55) and vascular endothelial growth factor A are oncogenes, all of which were associated with tumor stage, whereas only CEP55 was significantly associated with survival time as determined by Gene Expression Profiling Interactive Analysis. The mRNA expression levels of CEP55 in ccRCC samples were significantly higher than those observed in adjacent normal kidney tissues based on The Cancer Genome Atlas data and reverse transcription-polymerase chain reaction results. The receiver operating characteristic curve analysis revealed that CEP55 may be considered a diagnostic biomarker for ccRCC with an area under the curve of >0.85 in the training and validation sets. High CEP55 expression was strongly associated with sex, histological grade, stage, T classification, N classification and M classification. Univariate and multivariate Cox proportional hazards analyses demonstrated that CEP55 expression was an independent risk factor for poor prognosis. In addition, gene set enrichment analysis indicated that high CEP55 expression was associated with immunization, cell adhesion, inflammation, the Janus kinase/signal transducer and activator of transcription signaling pathway and cell proliferation. In conclusion, CEP55 was increased in ccRCC samples, and may be considered a potential diagnostic and prognostic biomarker for ccRCC.
Is the Botryococcus braunii Dry Biomass an Adjuvant for Anti-UVB Topical Formulations?

Several topical products have been developed to avoid the harmful effects from ultraviolet (UV) radiation, such as sunscreens. Research for actives from natural sources is increasing due to the fact that chemical filters could induce adverse events. The microalgae Botryococcus braunii has potential interest in cosmetic applications. Specialized literature reported that B. braunii aqueous extract induced a reduction in skin dehydration and collagen production and promoted antioxidant activity. This research aimed to produce B. braunii biomass and to investigate its contribution regarding photoprotection. Formulations containing B. braunii dry biomass, with or without UV filters into vehicles composed of an emulsifying polymer or a self-emulsifying base, were evaluated in vitro by means of photoprotective activity and photostability. B. braunii dry biomass did not provide adequate photoprotection efficacy; however, it was observed that the self-emulsifying base promoted better sun protection factor (SPF) in comparison with the emulsifying polymer.