Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysing the determinants of students’ loyalty in the higher education context: The Catalan University system case

The aim of this paper is twofold: (i) identify the determinants of students’ loyalty, and ii) characterise the profile of the recently graduate students within the Catalan University system. The empirical evidence is collected through the Satisfaction Graduate Survey promoted by the Catalan University Quality Assurance Agency. The analysis presented corresponds to the 2013 edition. Concretely, the survey was launched in October of 2013, and 2,557 questionnaires were collected, from which 2,337 were fully completed. The sample is mainly composed by women (62,9%) between 21 and 24 years old born in Catalonia. The main reason for choosing their studies are the preference for the study (62,3%) and job opportunities (15,1%). Moreover, most of the graduates combined learning and work (57,8%) and only 20,7% joined a mobility program during their studies. In terms of loyalty, 68,8% of the students would chose the same degree again, and 77,7% of them would remain at the same university. In fact, 62,3% of the sample are satisfied or very satisfied with the studied degree. Related to the determinants of students’ loyalty, our results show that higher is the loyalty of the student as higher is his/her satisfaction with the degree and the better the previous academic records of the student. However, results are inconclusive in terms of balancing study and work, engaging in mobility programs or getting involved in university associations. Female students are also shown to display higher levels of loyalty. As for the second research objective, students are grouped into three main groups: loyal and satisfied but not first choice of studies (cluster 1); unsatisfied (cluster 2); and loyal and satisfied (cluster 3).
Beneficial Health Effect of Aquarobics (Role of Adiponectin on Women with Obesity)

Background the effects of exercise on adiponectin levels have been reported to be variable. Obesity is associated with adipose tissue inflammation and increased risk of infection. The prevalence of obesity increased in premenopausal women both in developed countries and developing countries, including Indonesia. The purpose of the study to investigate the effect of aquarobics exercise on adiponectin levels in women with obesity. Methods of the research, experimental randomized pretest-posttest control group design performed in twenty four women with obesity (Obese II BMI> 30kg/m2) aged 45-50 years, who were divided into 2 groups, aquarobic exercise group, twice days for 8 weeks (n=12), aquarobic intensity 75%HRmax, and control group (n=12). Percentage of body fat, BMI, adiponectin levels, blood glucose and lipids profile were measured before and after exercise. Data were analyzed using repeated measures and while Pearson’s correlations were performed to identify possible relationship among the assessed variables. Results of the study, the percentage of body fat was higher in aquarobic exercises than control group (p<0.05). Decreased of BMI on the aquarobic exercises group compared to controls (p<0.05) and adiponectin levels in the aquarobic exercise group increase significantly (p<0.05). Conclusion: Aquarobic exercise is effective to decreased body weight and increase adiponectin levels.
Suivi du syndrome métabolique induit par les antipsychotiques atypiques : recommandations et perspectives pharmacogénétiques

Malgre une tolerance globale amelioree par rapport aux antipsychotiques classiques, les atypiques ne sont pas denues d'effets secondaires, notamment metaboliques (prise de poids, alteration du profil lipidique et glycemique). Ceux-ci sont particulierement preoccupants en termes de morbidite et mortalite a long terme. En se basant sur des consensus recemment publies, le departement de psychiatrie du Centre hospitalier universitaire vaudois (CHUV) a etabli une directive sur le suivi clinique des patients recevant des atypiques, directive que nous presentons ici. En outre, des etudes en pharmacogenetique montrent que la prise de poids et les alterations metaboliques induites par ce type de medication peuvent etre influencees par le patrimoine genetique des patients. Ceci permet d'esperer que, dans un avenir proche, le traitement pourra etre adapte individuellement a chaque patient.
Towards pathway and network-based medicine in breast cancer

III ACKNOWLEDGEMENTS V PREFACE VII INDEX IX PAPERS INCLUDED IN THE THESIS XI LIST OF ABBREVIATIONS XII LIST OF FIGURES AND TABLES XIII 1 OVERVIEW 1 1.1 Complexities underlying the molecular portraits of breast cancer 2 1.1.1 Motivation underlying the study of molecular profiles of tumor 2 1.1.2 Reasons for the limited clinical utility of molecular portraits 3 1.2 The histopathological classification 4 1.2. 1 Histopathological classes of breast cancer 4 1.2. 2 Pros and cons of histological classification 5 1.3 IHC in breast cancer 6 1.4 Combining the histopathology, IHC and molecular portraits in the clinics 7 1.4. 1 Commercially available assays for diagnostics 8 1.4. 2 Correspondence between IHC and molecular portraits 9 1.4. 3 Correspondence between the histopathology, IHC and molecular portraits 12 1.5 Pathway approach in breast cancer 13 1.5. 1 Pathways concept in context of cancer genomics 14 1.5. 2 Publicly available pathway databases 15 1.5. 3 Advantages of pathways-based analysis over individual gene-based analysis 15 1.6 Deregulation of transcriptional networks in cancer pathways 16 1.6. 1 Inference of transcriptional factors underlying deregulation 17 1.6. 2 Defining novel cancer classes by the activity of transcriptional hubs 18 1.7 Transcriptional deregulation by p53 in breast cancer 19 1.7. 1 Determinants of functional specificity and promoter selectivity of p53 20 1.8 Pathway-based molecular diagnostics 21 1.8. 1 Characteristics of malignancy and pathway aberrations 22 1.8. 2 Overview about pathway analysis approaches for genomic data 23 1.8. 3 Limitations of pathway-based analysis 25 1.9 Implications of pathway-based diagnostics on breast cancer therapeutics 26
Prevalence of Quinolone Resistance Genes in Klebsiella pneumoniae Strains Isolated from Hospitalized Patients During 2013 - 2014

Background: The increasing emergence of resistance among clinical isolates of Klebsiella pneumoniae (K. pneumoniae) has limited the therapeutic options used to treat infections caused by these bacteria. Objectives: The aim of this study was the molecular detection of quinolone resistance genes acrA, acrB, qepA, and aac(6’)-Ib-cr in K. pneumoniae strains isolated from hospitalized patients in selected hospitals in Tehran during 2013 - 2014. Methods: One hundred and seventeen strains of K. pneumoniae were isolated between August 2013 and March 2014 from hospitalized patients in Taleghani hospital, Mofid children’s hospital, and Imam Hossein hospital in Tehran. Antimicrobial susceptibility tests were performed using disk diffusion and broth microdilution methods based on CLSI guidelines. The identification of the genes that encode efflux pumps acrA, acrB, qepA, and aac(6’)-Ib-cr was done using the PCR technique. Results: Antimicrobial susceptibility tests showed that colistin and tigecycline had the best effect against clinical isolates of K. pneumoniae. The PCR assay detected the acrA and acrB genes in 110 (94%) and 102 (87%) isolates, respectively. Additionally, the qepA and aac(6’)-Ib-cr genes were detected in 5 (4%) and 100 (85%) isolates, respectively. Conclusions: The prevalence of the acrA, acrB, qepA, and aac(6’)-Ib-cr genes in K. pneumoniae, which causes resistance to fluoroquinolones, in this study is cause for concern. Based on our results, accurate identification of resistant Gram-negative bacteria such as K. pneumoniae and detection of its susceptibility to common antibiotics could lead to proper treatment and control of resistant nosocomial infections.
Current issues in the basic mechanisms, pathophysiology, diagnosis and management of primary ciliary dyskinesia

Depts of *Paediatrics, Cell Biology and Physiology, and **Internal Medicine, Washington University School of Medicine, St. Louis, MO, and Depts of Pediatricsand Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC, USA. Dept of Paediatrics and Child Health, Royal Free and University College Medical School, University College LondonDept of Paediatrics and Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
Obesity uncovered: diagnosis without treatment in plans offered on the 2015 health insurance marketplace

Background: Obesity is a public health problem that currently affects more than one-third of American adults. The Patient Protection and Affordable Care Act (ACA) requires all private health plans to cover diagnostic screening and counseling for obesity. However, the ACA does not guarantee access to effective treatment for obesity. Objective: To examine the health plans sold on the 2015 Health Insurance Marketplace (Marketplace) by describing the coverage and access barriers for surgical and non-surgical treatments for obesity. Methods: Using data from the 2015 Marketplace Public Use Files that consist of a census of all health plans sold on the 2015 Marketplace in 37 states, which excludes plans sold on the 14 State-based Marketplaces. Descriptive statistics are employed to characterize the plans’ coverage, exclusions, limitations, and out-of-pocket costs for bariatric surgery (surgical category), dietician services, nutritional counseling, gym access, gym membership, gym membership reimbursement, and weight loss programs (non-surgical category). Results: Bariatric surgery was covered by 30.4% of plans. Of these plans, over one-third applied a limit on the coverage amount. Of the plans covering bariatric surgery with a copayment, 60.3% of these plans had a copayment of $1,000 or more. In contrast, the non-surgical treatments were covered by more than 80% of plans. Of these plans with a copayment, 71.6% had a copayment between $1 and $49. Of the plans covering treatments in the surgical or non-surgical categories, coinsurance rates were more prevalent than copayments, with almost two-thirds of plans having a coinsurance rate of 50% or more. Conclusions: A majority of plans on the 2015 Marketplace covered non-surgical obesity treatments. However, bariatric surgery, the treatment that results in the greatest amount of weight loss, was covered by less than one-third of plans. Furthermore, bariatric surgery, even when covered, may be less accessible to patients with a Marketplace plan due to high cost sharing and limits on the coverage amount. This study is significant to public health because it provides an early description of the coverage and access barriers to obesity treatments available to Marketplace enrollees, highlighting the importance of promoting policy that expands coverage of and access to obesity treatments given the high prevalence of obesity in the U.S.
Comparative analysis of 6-0 nylon and 6-0 vicryl rapide in congenital unilateral cleft lip repair

Context: The type of suture material used in surgery has been a long standing debate among surgeons. In this study we compared rapidly absorbable suture material (Vicryl Rapide TM or Irradiated Polygalactin 910) with non-absorbable suture material (Nylon or Polyamide) in patients with nonsyndromic congenital unilateral cleft lip. Aims: To compare the appearance and course of scar, wound infection and patient′s parent perception between the two groups. Settings and Design: Randomized prospective controlled study. Methods and Material: 20 patients, in the age group of 3-18 months were randomly allocated to two groups with 10 patients each. Skin suturing was done with 6-0 Polyamide and 6-0 Irradiated polygalactin the respective groups. Patients were evaluated at 1 week, 1 month, 3 months, 6 months and 1 year postoperatively by the observer as well as by the patient′s parent. Results and Conclusion: It was found that Vicryl Rapide showed poorer cosmetic outcomes regarding height and pigmentation of scar as compared to nylon sutures.However, this sample size and follow-up period is very small to generalize these findings.
TH588 Potently Kills Melanoma Cells Grown in 3-Dimensional Culture Through Apoptosis Induced by ROS

MutT homolog 1 sanitizes oxidized dNTP pools through converting 8-oxo-deoxy-guanine (8-oxo-dGTP) and 2-OHdeoxy- adenosine (2-OH-dATP) into the corresponding monophosphates, thus protecting cells from DNA damage caused by reactive oxygen species (ROS).
Optimal Peak and Mean Power on the Wingate Test: Relationship with Sprint Ability, Vertical Jump, and Standing Long Jump in Boys

The first purpose of the present study was to test sensitivity of the Wingate anaerobic test (WAnT) to alterations in resistance settings. The second purpose was to investigate whether using optimal braking force on WAnT enhances its relation with a 50-m dash, a vertical jump (VJ), or a standing long jump (LJ) tests. Twenty-three 12 year-old boys performed a 50-m dash, VJ, LJ, and WAnT using four braking force resistances (BFR; .065, .070, .075, and .080 kp/kg BM). Results revealed significant (p ≤ .05) differences among the four BFRs in peak power (PP) and in mean power (MP). Post hoc tests indicated significant differences among all of the four BFRs in PP and between the 0.065 and both the 0.075 and the 0.08 kp/kg BM in MP. Results of Pearson correlation coefficients indicated that using the optimal BFR for both PP and MP enhanced their relation with performance during the 50-m dash, VJ, and LJ tests. Also, partial correlation coefficients, controlling for body weight, height, percent fat, or body mass .
Calcium-Sensing Receptor Antagonists Abrogate Airway Hyperresponsiveness and Inflammation in Allergic Asthma

PL Yarova, AL Stewart, V Sathish. Sci Transl Med. 2015;7(284):1–11 The symptoms of asthma are potentially controllable in most asthmatic patients using conventional therapy, but there is an unmet need for identification of novel asthma therapies that target the root cause of the disease rather than its clinical sequelae. Primary human airway smooth muscle (ASM) cells were obtained from surgical lung specimens of patients undergoing lobectomy for focal noninfectious disease, including 5 each from patients with moderate asthma and …
A genetic investigation of the muscle and neuronal channelopathies: from Sanger to next-generation sequencing

The neurological channelopathies are a group of hereditary, episodic and frequently debilitating diseases often caused by dysfunction of voltage-gated ion channels. This thesis reports genetic studies of carefully clinically characterised patient cohorts with different episodic neurological and neuromuscular disorders including paroxysmal dyskinesias, episodic ataxia, periodic paralysis and episodic rhabdomyolysis. Genetic and clinical heterogeneity has in the past, using traditional Sanger sequencing methods, made genetic diagnosis difficult and time consuming. This has led to many patients and families being undiagnosed. Here, different sequencing technologies were employed to define the genetic architecture in the paroxysmal disorders. Initially, Sanger sequencing was employed to screen the three known paroxysmal dyskinesia genes in a large cohort of paroxysmal movement disorder patients and smaller mixed episodic phenotype cohort. A genetic diagnosis was achieved in 39% and 13% of the cohorts respectively, and the genetic and phenotypic overlap was highlighted. Subsequently, next-generation sequencing panels were developed, for the first time in our laboratory. Small custom-designed amplicon-based panels were used for the skeletal muscle and neuronal channelopathies. They offered considerable clinical and practical benefit over traditional Sanger sequencing and revealed further phenotypic overlap, however there were still problems to overcome with incomplete coverage. Large custom and non-custom pull-down panels were used to investigate patients with recurrent rhabdomyolysis patients. The contribution of genetic abnormalities was determined, and it was concluded that while the contribution of the RYR1 was substantial, it was minimal for the classic voltage-gated ion channels SCN4A and CACNA1S Lastly, whole-exome sequencing was applied to two large undiagnosed possible channelopathy families. One family was found to indeed harbour a channelopathy mutation, whilst the other did not. Overall, next-generation sequencing proved to be a more thorough and efficient method for channelopathy genetic diagnosis and several novel findings throughout the thesis expanded the current knowledge within the field.
Orotracheal Continuous Positive Airway Pressure With a Compensation Bag: A Preliminary Report About a New Technique for Assisted Ventilation in Premature Infants

Objective: We used a rubber bag adapted for ventilation with orotracheal continuous positive airway pressure (CPAP), to provide constant alveolar distention pressure and alveolar stability while compensating for pressure or volume changes from physiological events like coughing or crying. Materials and Methods: We administered orotracheal CPAP with compensation bag to nine newborns with mean weight of 1077 g (range, 779-1311 g) and mean gestational age of 28.5 weeks (range, 26 30 weeks). All infants underwent measurement of blood gases and vital signs, and chest radiographs. Results: Orotracheal CPAP with compensation bag was effective in eight patients; high-frequency oscillatory ventilation for pulmonary arterial hypertension was required in one patient. No adverse events were attributable to the procedure. Mean time to extubation was 86 hours. Conclusions: This simple compensation bag may provide alveolar protection and stability for infants who require mechanical ventilation. This technique opens a new line of research in assisted ventilation.
UV Irradiation of Skin Regulates a Murine Model of Multiple Sclerosis

Objective: The prevalence of multiple sclerosis follows a latitude gradient, with increased disease at higher latitudes. Previous studies have focused on a vitamin D hypothesis; although recent evidence suggests that exposure to ultraviolet radiation (UVR) itself may be important. In this study, the effects of UVR on the development of experimental autoimmune encephalomyelitis (EAE) were examined. Methods: C57BL/6 mice were irradiated with a single erythemal dose of UVR (8 kJ/m2), or 4 daily sub-erythemal doses (1 kJ/m2), before sensitisation to myelin oligodendrocyte glycoprotein peptide. The UV irradiation protocols used do not increase 25-hydroxyvitamin D concentrations in serum of vitamin D-sufficient mice. The onset of EAE was recorded and mice were clinically monitored for 40 days. Results: A single dose of erythemal UVR (8 kJ/m2) significantly suppressed EAE onset and severity. Four daily exposures of sub-erythemal UVR (1 kJ/m2) also significantly delayed disease onset but was less effective than the erythemal dose. Conclusion: UV irradiation delayed the onset and reduced the severity of EAE. Continued administration of lower dose UVR following disease onset may be necessary to achieve similar results to a single higher dose delivered presensitisation. Our results give further weight to suggestions that UVR exposure may delay MS onset and progression and UVB phototherapy may provide an option for treatment of MS.
SURGERY FOR CONGENITAL HEART DISEASE

Objective: We investigated the subdiaphragmatic venous physiology in patients subjected to the Fontan operation to understand some of the early and late problems of this circulation. Methods: Flows were evaluated by Doppler ultrasonography in the subhepatic inferior vena cava, hepatic vein, and portal vein during respiratory monitoring and with a tilt table. Twenty control subjects (group A) and 56 patients who had the Fontan operation, 27 in functional class I (group B) and 29 in class III or IV (group C), were studied. Inspiratory/expiratory flow ratio was calculated to reflect respiratory effects, and upright/supine flow ratio was calculated to assess gravity effects. Inferior vena caval, hepatic venous, and wedged hepatic venous pressures were measured during catheterization in 21 control subjects and 25 Fontan patients. The difference between wedged and hepatic venous pressures represents the transhepatic venous pressure gradient. Results: Fontan hepatic venous flow depended more on inspiration than control, but without difference between groups B and C (inspiratory/expiratory flow ratios: 1.7, 2.9, and 2.9, respectively; P < .02). Normal portal venous flow was higher in expiration; this effect was lost in group B and reversed in group C (inspiratory/expiratory flow ratios: 0.8, 1.0, and 1.3; P < .0005). Gravity reduced portal venous flow in groups A and B, but progression to functional class III or IV (group C) exacerbated this effect (upright/supine flow ratios: 0.8, 0.7, and 0.5; P < .01). Inferior vena caval, hepatic venous, and wedged hepatic venous pressures (in millimeters of mercury) in the Fontan groups were all elevated compared with the control group (inferior vena cava, 14.4 ± 4.4 vs 5.9 ± 2.3; hepatic vein, 14.7 ± 4.5 vs 5.9 ± 1.9; wedged hepatic vein, 14.7 ± 4.0 vs 8.3 ± 2.6; P < .0001). However, transhepatic venous pressure gradient in the Fontan group was lower than in the control group (0.5 ± 0.5 vs 2.4 ± 2.0; P < .001). Univariate analysis of inferior vena caval pressure and transhepatic venous pressure gradient showed significant inverse correlation (r = 0.6, P < .002). Conclusions: In patients who are in functionally poorer condition after the Fontan operation, portal venous flow loses normal expiratory augmentation and adverse gravity influence is enhanced. These suboptimal flow dynamics, coupled with higher splanchnic venous pressures and lower transhepatic
Assessment of the Impacts from the Addition of Novel Assistive Technologies in Mental Health Care

This proceeding seeks to understand changes to the current model of mental health care that will occur if computer programs and smartphone applications that augment therapy become widely used in practice. Current human factors research in home healthcare, as well as the application of the SEIPS 2.0 model to the current system of mental health care are used to predict the potential risks involved in these new technologies. This proceeding explores technologies that seek to assist in normal treatment protocols as well as technologies that are intended to replace normal psychological visits. Using this model to compare assistive versus replacement technologies for mental health treatment, it was found that replacement technologies pose greater risk and should be thoroughly assessed within the system context of mental health. This paper points to areas that should be explored further to assess the safety of these applications and to fuel designs that are safe and usable by a broader population.