Miracle-dz/UniFAR-FTUs huggingface dataset:
A Case of Osteonecrosis of the Jaw in a Patient with Crohn’s Disease Treated with Infliximab

Patient: Female, 49 Final Diagnosis: Medication related osteonecrosis of the jaw Symptoms: Painful bone exposure • pus discharge Medication: Infliximab Clinical Procedure: Surgical removal of necrotic bone Specialty: Surgery Objective: Unusual clinical course Background: Medication-related osteonecrosis of the jaw (MRONJ) is a severe adverse drug reaction, occurring in patients undergoing treatments with antiresorptive or antiangiogenic agents, such as bisphosphonates, denosumab, or bevacizumab, for different oncologic and non-oncologic diseases. The aim of this study was to report a case of MRONJ in a patient taking infliximab, an anti-TNF-α antibody used to treat Crohn’s disease, rheumatoid arthritis, ulcerative colitis, ankylosing spondylitis, psoriatic arthritis, and plaque psoriasis. Case Report: A 49-year-old female patient affected by Crohn’s disease, who had been undergoing 250 mg intravenous infliximab every six weeks for 12 years, with no history of antiresorptive or antiangiogenic agent administration, came to our attention for post-surgical MRONJ, associated with a wide cutaneous necrotic area of her anterior mandible. Following antibiotic cycles, the patient underwent surgical treatment with wide bone resection and debridement of necrotic tissues; after prolonged follow-up (16 months), the patient completely healed without signs of recurrence. Conclusions: Prevention of MRONJ by dental check-up before and during treatments with antiresorptive treatments (bisphosphonates or denosumab) is a well-established procedure. Although further studies are required to confirm the role of infliximab in MRONJ, based on the results of this study, we propose that patients who are going to be treated with infliximab should also undergo dental check-up before starting therapy, to possibly avoid MRONJ onset.
Promoter-Specific Shifts in Transcription Initiation Conferred by Yeast TFIIB Mutations Are Determined by the Sequence in the Immediate Vicinity of the Start Sites

ABSTRACT The general transcription factor IIB (TFIIB) is required for transcription of class II genes by RNA polymerase II. Previous studies demonstrated that mutations in the Saccharomyces cerevisiae SUA7 gene, which encodes TFIIB, can alter transcription initiation patterns in vivo. To further delineate the functional domain and residues of TFIIB involved in transcription start site utilization, a genetic selection was used to isolate S. cerevisiae TFIIB mutants exhibiting downstream shifts in transcription initiation in vivo. Both dominant and recessive mutations conferring downstream shifts were identified at multiple positions within a highly conserved homology block in the N-terminal region of the protein. The TFIIB mutations conferred downstream shifts in transcription initiation at the ADH1 and CYC1 promoters, whereas no significant shifts were observed at the HIS3 promoter. Analysis of a series of ADH1-HIS3 hybrid promoters and variant ADH1 and HIS3 promoters containing insertions, deletions, or site-directed base substitutions revealed that the feature that renders a promoter sensitive to TFIIB mutations is the sequence in the immediate vicinity of the normal start sites. We discuss these results in light of possible models for the mechanism of start site utilization by S. cerevisiae RNA polymerase II and the role played by TFIIB.
A survey of inverse reinforcement learning techniques

Purpose – This purpose of this paper is to provide an overview of the theoretical background and applications of inverse reinforcement learning (IRL). Design/methodology/approach – Reinforcement learning (RL) techniques provide a powerful solution for sequential decision making problems under uncertainty. RL uses an agent equipped with a reward function to find a policy through interactions with a dynamic environment. However, one major assumption of existing RL algorithms is that reward function, the most succinct representation of the designer's intention, needs to be provided beforehand. In practice, the reward function can be very hard to specify and exhaustive to tune for large and complex problems, and this inspires the development of IRL, an extension of RL, which directly tackles this problem by learning the reward function through expert demonstrations. In this paper, the original IRL algorithms and its close variants, as well as their recent advances are reviewed and compared.Findings – This pape.
Patterns of decline and evidence of subgroups in patients with Alzheimer's disease taking galantamine for up to 48 months

Lacking long‐term placebo‐controlled trials of cholinesterase inhibitors (ChEIs) in Alzheimer's disease, how decline is modeled is crucial to interpreting the effects of long‐term, open‐label use. We aimed to: 1) understand changes in cognition and function in people taking galantamine; (2) identify treatment subgroups.
Simple linear flow decomposition algorithms on trees, circles, and augmented trees

The flow decomposition algorithm transforms an arc flow‐based solution to a network flow problem into flows on directed paths and cycles. When the undirected graph induced by arcs with positive flow is a tree, a circle, or an augmented tree (with n nodes), the standard implementation of the algorithm runs in O (n2) time. In this article, we exploit the structure of the network to develop an O (n) flow decomposition algorithm. The run‐time relies on the property that for these networks, paths or cycles can be represented implicitly in O (1) space. The algorithm is easy to implement and does not use complicated data structures. Because the size of the input is O (n), our algorithm is the fastest possible for flow decomposition on these special networks. Our algorithm can be used to improve run‐times for solving matching and transportation problems on trees and circles. © 2012 Wiley Periodicals, Inc. NETWORKS, 2012
A Novel Particle Swarm Optimization Approach for Multiobjective Flexible Job Shop Scheduling Problem

PCT No. PCT/GB94/02821 Sec. 371 Date Apr. 13, 1998 Sec. 102(e) Date Apr. 13, 1998 PCT Filed Dec. 23, 1994 PCT Pub. No. WO95/17779 PCT Pub. Date Jun. 29, 1995An electrical machine, such as an electric motor, dynamo or alternator has a casing (26) with cooling vents (64) enabling cooling fluid (F) to flow into and out of the casing when the rotor (10) of the electrical machine rotates. The rotor (10) may be formed from conductive elements (44) connected together at their outer regions by inter-connecting members (40) which have vanes (68, 70) arranged to direct cooling fluid over the outer regions. Each conductive element (44) is a metal strip (45) with legs (46, 48) bent in opposite directions (D1, D2) relative to the plane of the strip. Portions of the windings (28, 30) of the rotor (10) are spaced apart to allow fluid to flow between the windings to enhance the cooling effect. With a current carrying rotor, the magnetic field intensity across the rotor is varied by varying the axial separation of the rotor and the stator (74, 76).
Least mean square error-based image compression using block truncation coding

Block truncation coding is one of the image compression techniques which has low computational complexity. This lossy compression technique divides the image into equal block sizes and the pixels in each block are replaced with a high mean and low mean value based on the mean as the threshold. The bit plane thus obtained after quantisation is transmitted along with the mean and variance. This gives a bit rate of 2 bits per pixel. Nevertheless, when the block size is increased for obtaining higher compression ratio, the image is dominated by severe blocking artefacts and blurred edges thereby reducing the visual quality of the image. In the proposed method the mean square error is calculated iteratively for the blocks. The pixels are grouped into higher order and lower order blocks and the group which produces the least mean square error is transmitted along with the mean values of the higher order and lower order block. This implies that the image which is retrieved in the receiver gives the optimised visual quality in the least mean square sense.
Multivariate analyses suggest genetic impacts on neurocircuitry in schizophrenia

We investigated the relationship of functional neurocircuitries and dopamine receptor D1 (DRD1) polymorphisms in schizophrenics during a working memory task. Participants performed the Serial Item Recognition Paradigm memory task during functional magnetic resonance imaging acquisition. We performed a data-driven multivariate analysis (partial least squares) to characterize brain network (covariance) patterns. Genetic testing identified two main genotypes. Accuracy did not differ between the groups. Covariance patterns of different areas (including the dorsolateral prefrontal cortex and the inferior parietal lobule) were inversely related between the two genotypes. Two groups of schizophrenic patients with similar symptomatology and performance on a working memory task, but with distinct dopamine receptor genotypes, may use distinct neural systems to retrieve information.
The Influence of Familiarity and Emotion on Mimicry

The objective of the present study is to verify whether there is a difference in the occurrence of facial mimicry between friends and strangers and the type of expressed emotion. Two distinctions were made: friends and strangers talking about a happy story (positive emotion) and a sad story (negative emotion). An experiment was conducted to get data for analysis. Two participants were asked to have a conversation with each other, about a happy and sad topic, while being video recorded. Afterwards some questionnaires were handed out. Results showed that there exists a difference in the occurrence of mimicry between friends and strangers talking about a sad topic. No difference in the occurrence of mimicry was found between friends and strangers talking about a happy topic. Further research is needed to have more assurance of the results because of the small sample that has been used.
Evaluation of Tree-Trellis Based Decoding in Over-Million LVCSR

Very large vocabulary continuous speech recognition (CSR) that can recognize every sentence is one of important goals in speech recognition. Several attempts have been made to achieve very large vocabulary CSR. However, very large vocabulary CSR using a tree-trellis based decoder has not been reported. We report the performance evaluation and improvement of the “Julius” tree-trellis based decoder in large vocabulary CSR (LVCSR) involving more than one million vocabulary, referred to here as over-million LVCSR. Experiments indicated that Julius achieved a word accuracy of about 91% and a real time factor of about 2 in over-million LVCSR for Japanese newspaper speech transcription.
Quantum LQG Control with Quantum Mechanical Controllers

Abstract Based on a recently developed notion of physical realizability for quantum linear stochastic systems, we formulate a quantum LQG optimal control problem for quantum linear stochastic systems where the controller itself may also be a quantum system and the plant output signal can be fully quantum. This is distinct from previous works on the quantum LQG problem where measurement is performed on the plant and the measurement signals are used as input to a fully classical controller with no quantum degrees of freedom. The difference in our formulation is the presence of additional non-linear and linear constraints on the coefficients of the sought after controller, rendering the problem as a type of constrained controller problem. Due to the presence of these constraints our problem is inherently computationally hard and this distinguishes it in an important way from the standard LQG problem. We propose a numerical procedure for solving this problem based on an alternating projections algorithm and, as initial demonstration of the feasibility of this approach, we provide a fully quantum controller design example in which a numerical solution to the problem was successfully obtained.
In vivo tumor co-transfection with superantigen and CD80 induces systemic immunity without tolerance and prolongs survival in mice with hepatocellular carcinoma

Background: Since transfection of established tumors with immunostimulatory genes can elicit antitumor immunity, we treat mouse HCC with in vivo transfection of superantigen SEA and/or costimulatory molecule CD80 and evaluated the safety and efficacy. Methods Mice with HCC were treated with lipid-complexed plasmid DNA encoding staphylococcal enterotoxin A and/or CD80. Then the mice were evaluated for tumor regression, systemic immunologic responses, survival times and treatment-associated toxicity. Results Of all treated mice, the overall response rates (complete or partial remission) for SEA, CD80 and SEA/CD80 treated mice in this study were 65%, 60% and 75% separately, and were significantly higher than that of untreated mice. Most of the treat mice completed the therapy without any significant reaction. CTL activity increased with time of treatment and correlated temporally with an objective tumor response. Also our results indicated that local intratumoral expression of SEA did not lead to detectable deletion or anergy of SEA-reactive spleen T cells. Survival times for hepatoma mice in this study treated by intratumoral injection of SEA, CD80 and SEA/CD80 were prolonged significantly (P < 0.01) compared with the control mice. Conclusions Thus, local tumor transfection with superantigen and CD80 genes was capable of inducing strong systemic antitumor immunity.
Noncentrosomal microtubules in C. elegans epithelia

The microtubule cytoskeleton has a dual contribution to cell organization. First, microtubules help displace chromosomes and provide tracks for organelle transport. Second, microtubule rigidity confers specific mechanical properties to cells, which are crucial in cilia or mechanosensory structures. Here we review the recently uncovered organization and functions of noncentrosomal microtubules in C. elegans epithelia, focusing on how they contribute to nuclear positioning and protein transport. In addition, we describe recent data illustrating how the microtubule and actin cytoskeletons interact to achieve those functions. genesis, 2016. © 2016 Wiley Periodicals, Inc. genesis 54:229–242, 2016. © 2016 Wiley Periodicals, Inc.
The effects of rope or weighted rope jump training on strength, coordination and proprioception in adolescent female volleyball players.

AIM The aim was to assess the effects of a 12-week "rope jumping" and "weighted rope jumping" training programs on functional parameters including multi-joint coordination and proprioception, strength, endurance in adolescent female volleyball players. METHODS Pretest posttest experimental design. INTERVENTION Weighted Rope Training group (N.=9; 15±1 years), Rope Training group (N.=9; 14.1±1.3 years) and Controls (N.=7; 14.4±1.3 years). MAIN OUTCOME MEASURES Motor coordination, proprioception, strength and endurance of the lower extremities with concentric and eccentric performances in closed kinetic chain on multi joint system assessed by the Monitorized Squat system. Absolute average error (cm) and the standard deviation for coordination and proprioception, Peak Force (N), Total Work (Nm), Average Power (Nm/s), Maximal Speed for strength and endurance tests were calculated. Kruskal-Wallis and Mann Whitney U test were utilized. RESULTS Weighted rope jump group had significant decrease for the deviation results of coordination on the concentric and eccentric phases for both legs (P<0.05). Rope jump and weighted rope jump groups had significantly lower results on non visible second movement deviation (P<0.05). In strength tests, the difference was found for total work that there was difference on the post assessment within groups in favour of Weighted Rope Training group in comparison to controls (P<0.05). Weighted Rope Training and control groups improved in concentric maximal speed (P<0.05). Most significant changes occured on eccentric phaese of the endurance tests that peak force increased in Weighted Rope Training group (P<0.05). CONCLUSIONS Adding rope jump to training programs improves joint repositioning and coordination. Weighted Rope Training group got greater gains for coordination and eccentric endurance parameters for lower extremities in a closed kinetic chain.
Source-initiated adaptive routing algorithm (SARA) for autonomous wireless local area networks

Conventional routing protocols used in wireline and wireless networks are not designed to operate in an autonomous (or ad hoc) wireless local area network (AWLAN) environment with asymmetric (i.e. unidirectional) links. This paper presents the design of a routing protocol called source-initiated adaptive routing algorithm (SARA), for AWLAN environments that may contain asymmetric links. To allow efficient operation in a symmetric network while ensuring correct operation in asymmetric networks, SARA supports two different modes of protocol operation: one optimized for symmetric networks and the other providing additional capabilities needed for operation in asymmetric networks at a higher cost. The ability of SARA to adapt its mode of operation and optimize its execution for each network environment is one of its major advantages and distinguishes it from existing routing protocols for, wireless networks. Furthermore, within each of its operating modes, SARA supports best-effort as well as policy-based routing.
Sensor for ambient pressure and material strains using a thin film bulk acoustic resonator

In this contribution we will outline concepts for the operation of a Thin Film Bulk Acoustic Resonator (FBAR) as a sensor for ambient pressure and material strains. We develop a model to evaluate its sensitivity. Measurements with an FBAR solidly mounted on a silicon Wafer show the principal suitability of this device as a stress sensor. FBAR, Stress Sensor, ZnO
FIRST GAMMAHERPESVIRUS DETECTION IN A FREE-LIVING MEDITERRANEAN BOTTLENOSE DOLPHIN

Abstract: Recently, herpes viruses have been detected in different cetacean species from the Atlantic and in Mediterranean striped dolphins (Stenella coeruleoalba). While pathogens such as cetacean morbillivirus have been widely studied following recent epizootics, herpesvirus (HV) distribution and pathogenic effects in cetaceans are still understudied. This study reports the first molecular identification of a Gammaherpesvirus in the genital mucosa of a free-living Mediterranean bottlenose dolphin (Tursiops truncatus) stranded off the coast of central Italy. Sequenced herpesviral PCR product was closely related to other HVs recently isolated in the genital mucosa of various cetacean species.
Phytosphingosine-1-Phosphate Is a Signaling Molecule Involved in Miconazole Resistance in Sessile Candida albicans Cells

ABSTRACT Previous research has shown that 1% to 10% of sessile Candida albicans cells survive treatment with high doses of miconazole (a fungicidal imidazole). In the present study, we investigated the involvement of sphingolipid biosynthetic intermediates in this survival. We observed that the LCB4 gene, coding for the enzyme that catalyzes the phosphorylation of dihydrosphingosine and phytosphingosine, is important in governing the miconazole resistance of sessile Saccharomyces cerevisiae and C. albicans cells. The addition of 10 nM phytosphingosine-1-phosphate (PHS-1-P) drastically reduced the intracellular miconazole concentration and significantly increased the miconazole resistance of a hypersusceptible C. albicans heterozygous LCB4/lcb4 mutant, indicating a protective effect of PHS-1-P against miconazole-induced cell death in sessile cells. At this concentration of PHS-1-P, we did not observe any effect on the fluidity of the cytoplasmic membrane. The protective effect of PHS-1-P was not observed when the efflux pumps were inhibited or when tested in a mutant without functional efflux systems. Also, the addition of PHS-1-P during miconazole treatment increased the expression levels of genes coding for efflux pumps, leading to the hypothesis that PHS-1-P acts as a signaling molecule and enhances the efflux of miconazole in sessile C. albicans cells.
Design of a three-phase unity power factor single-stage telecom rectifier

This paper presents the design and implementation of a three-phase unity power factor single-stage rectifier. The main use of the converter is expected to be in the telecommunications industry where it supplies constant DC voltage to the telecom network and charges the high capacity batteries while providing unity power factor to the utility. The converter is based on the flyback topology operating in discontinuous current mode (DCM). A fast dynamic response, low cost, small size, and a very simple control are the further viable benefits of the converter. The study includes finding an optimum transformer design with the lowest leakage inductance and the selection of components with the lowest parasitic effects for high efficiency and good performance. After the design is verified using the Simulink and PLECs models of the converter, a full-scale prototype was implemented to evaluate the performance of the design. Finally, experimental results demonstrate that converter works successfully and meet the design expectations.
Psychological Features of Delinquent and Nondelinquent Male and Female Adolescent

The aim of present research is to determining Psychological Features of delinquent boys and girls in comparison to other non-delinquent groups. In doing this 120 delinquent individuals (60 boys and 60 girls) were compared with SCL-90-R after equalizing. Findings showed that delinquent boys manifest significant differences in all different aspects of depression, physical complains, obsession, persistence, anxiety, sensitivity in inter-personal relationship, psychosis, paranoid thoughts, aggression, phobia. Delinquent girls, also, in different aspect of study, like anxiety and physical complain received higher marks in compare with their similar group.
Alltagsroutinen klimafreundlicher gestalten

Das alltagliche Verhalten hat einen zentralen Einfluss auf die individuelle Klimabilanz. Bisher wird allerdings die Bedeutung dieser Alltagsroutinen im Klimaschutz nur wenig beachtet. Wie kann kommunale Klimapolitik dazu beitragen, klimabelastende Alltagspraktiken zu verandern?
A novel drag test for observing lubricant redistribution due to head-disk interactions

The redistribution of a thin perfluoropolyether lubricant film on magnetic rigid disks after sliding was studied by mapping the surface reflectivity under polarized light using an optical surface analyzer. Both lubricated and nonlubricated regions were created on the disks with a special dip-coating process, and a drag test was conducted with the head placed in the smooth data zone. Due to sliding, a portion of the lubricant film in the initially lubricated regions was displaced into the nonlubricated regions. A numerical procedure was developed to determine lubricant thickness profiles from the surface reflectivity data calibrated by FTIR. The displaced lubricant volume increases with increasing sliding time, increasing initial lubricant thickness, or decreasing sliding speed. Local removal of a lubricant film was observed after long-term parking of the head, and surface diffusion was examined for the diminishing displaced lubricant band.
Scrutinizing the Rule: Privacy Realization in HIPAA

Privacy policies, laws, and guidelines have been cultivated based on overly verbose specifications. This article claims that privacy regulations lend themselves to a firmer language based on a model of flow of personal identifiable information. The model specifies a limited number of situations and acts on personal identifiable information. As an application of the model, the model is applied to portions of the Privacy Rule of Health Insurance Portability and Accountability Act (HIPAA).