Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of Carbon Dioxide on Respiratory Function during Posterior Retroperitoneoscopic Adrenalectomy in Prone Position

Objective: To evaluate the influences of CO<sub>2</sub> insufflation on changes in blood gas analysis and end tidal CO<sub>2</sub> tension (PetCO<sub>2</sub>) during posterior retroperitoneoscopic adrenalectomy in the prone position. Methods: Arterial blood gas analysis and measurements of PetCO<sub>2</sub> were carried out during CO<sub>2</sub> insufflation in 16 patients who underwent posterior retroperitoneoscopic adrenalectomy in the prone position (PRA group). The results were compared to 10 patients who underwent open posterior adrenalectomy (OPA group). Ventilation was artificially controlled during the study period in all cases. Results: Arterial pH, PaCO<sub>2</sub>, PetCO<sub>2</sub> and PaO<sub>2</sub> were not significantly different between the PRA and OPA groups. However, the PaCO<sub>2</sub>–PetCO<sub>2</sub> gradient in the PRA group was significantly higher than that in the OPA group (p < 0.01). Conclusion: Transperitoneal absorption of CO<sub>2</sub> occurs in patients undergoing retroperitoneoscopy in the prone position. The alveolo-arterial CO<sub>2</sub> gradient may be the only parameter which indicates the absorption of CO<sub>2</sub> during PRA.
Voltage collapse issue in a photovoltaic source operating in an islanded microgrid

Microgrids provide an effective way to integrate distributed energy sources, particularly renewable energy sources, into the power system. Renewable energy sources differ from traditional microsources as their generation is variable depending on weather conditions. To achieve the highest renewable energy utilisation, photovoltaic (PV) panels tend to be operated at their maximum power point which also forms the boundary for stable operation. In this arrangement the DC bus voltage can collapse should the PV panels be overloaded. In an islanded microgrid, a droop controller is adopted to limit reactive power as well as distribute real power demand amongst the microsources. This paper proposes a modification to the droop controller to ensure a PV source remains within its maximum power limit. Simulation results are presented to demonstrate the controller's effectiveness.
Protecting data from malware threats using machine learning technique

Cyber attacks against sensitive data have become as serious threats all over the world due to the rising applications of computer and information technology. New malware or malicious programs are released everyday by cyber criminals through the Internet in an attempt to steal or destroy important data. Hence, research on protecting data receives tremendous interest in the cyber community. In order to cope with new variants of malicious software, machine learning techniques can be used for accurate classification and detection. This paper proposes an efficient scheme for malware detection for protecting sensitive data from malicious threats using data mining and machine learning techniques. Experimental results shows that the proposed approach gives better performance compared to other similar methods.
Generalized Absolute Stability Using Lyapunov Functions With Relaxed Positivity Conditions

Conditions are given for verifying stability and computing upper bounds on the induced (regional) <inline-formula> <tex-math notation="LaTeX">$\mathcal {L}_{2}$ </tex-math></inline-formula> gain for systems defined by vector fields which are, along with their Jacobian, rational in the states and sector bounded nonlinearities. A class of candidate Lyapunov functions is considered that are polynomial on the states and the nonlinearities and have a polynomial scaled Lurie–Postnikov term. The main result of this letter is a set of conditions that relax the requirement on the candidate Lyapunov function from being sum-of-squares with respect to the nonlinearities and the Lurie–Postnikov terms from being non-negative.
Differentiating households to analyze consumption patterns: a data mining study on official household budget data

Official data, administered by National Statistic Institutes (NSIs), play crucial role for being a major element of the governmental economic and social decision‐making process. This strategic role raises a significant necessity for statistical authorities to adopt new data tools to shift the statistical quality of the published data to a higher level. Data mining (DM) techniques and algorithms are promising tools to provide new ways to mine the crucial, complex, and voluminous official data to complement or substitute the traditional and lagged‐behind tools that NSIs have been using. This study addresses this potential utilization of DM tools on official data with a specific problem in an important survey for official statistics: Household Budget Survey. Through this study, clustering techniques are employed to characterize the household types and association rule mining technique is used to mine consumption patterns for each differentiated type. It is aimed to integrate the proposed model into data preprocessing procedure of the NSI to be able to engage in the real time analyses and to contribute exactness and timeliness of the data. WIREs Data Mining Knowl Discov 2018, 8:e1227. doi: 10.1002/widm.1227
Characterization With Scanning Electron Microscopy/Energy-Dispersive X-ray Spectrometry of Microtraces From the Ligature Mean in Hanging Mechanical Asphyxia: A Series of Forensic Cases

Abstract The authors applied scanning electron microscopy with energy-dispersive x-ray spectrometry to the furrow derived from hanging means. The study was conducted with the purpose to detect possible extraneous microtraces, deriving from the ligature, that could have had an interaction with the cutaneous biological matrix, thanks to a transfert mechanism, in the proximities of the lesion. Fifteen cutaneous samples of the furrow and an equal number of fragments of graphite tape, directly positioned on the lesion produced by the ligature mean and used as a “conductor” of possible traces, were analyzed using scanning electron microscopy with energy-dispersive x-ray spectrometry. The research of microscopic traces on the furrow using this technique highlights extraneous traces leading to 3 main categories: natural fabrics, and synthetic and metallic materials, excluding possible environmental pollutants. The analysis, run on 7 hanging deaths, made available by the judicial authority, found a morphological and compositional compatibility with the traces found on the cutaneous furrow produced during hanging. The technique used in this study is innovative in the pathological-forensic field, and can be considered useful in clarifying and studying this typology of asphyxia leading to a specific ligature material, when missing, or attributing the cause of death to hanging when the furrow is not macroscopically obvious.
The Transtheoretical Model of Health Behavior Change

The transtheoretical model posits that health behavior change involves progress through six stages of change: precontemplation, contemplation, preparation, action, maintenance, and termination. Ten processes of change have been identified for producing progress along with decisional balance, self-efficacy, and temptations. Basic research has generated a rule of thumb for at-risk populations: 40% in precontemplation, 40% in contemplation, and 20% in preparation. Across 12 health behaviors, consistent patterns have been found between the pros and cons of changing and the stages of change. Applied research has demonstrated dramatic improvements in recruitment, retention, and progress using stage-matched interventions and proactive recruitment procedures. The most promising outcomes to date have been found with computer-based individualized and interactive interventions. The most promising enhancement to the computer-based programs are personalized counselors. One of the most striking results to date for stage-matched programs is the similarity between participants reactively recruited who reached us for help and those proactively recruited who we reached out to help. If results with stage-matched interventions continue to be replicated, health promotion programs will be able to produce unprecedented impacts on entire at-risk populations.
Automatic Test Pattern Generator for Fuzzing Based on Finite State Machine

With the rapid development of the Internet, several emerging technologies are adopted to construct fancy, interactive, and user-friendly websites. Among these technologies, HTML5 is a popular one and is widely used in establishing modern sites. However, the security issues in the new web technologies are also raised and are worthy of investigation. For vulnerability investigation, many previous studies used fuzzing and focused on generation-based approaches to produce test cases for fuzzing; however, these methods require a significant amount of knowledge and mental efforts to develop test patterns for generating test cases. To decrease the entry barrier of conducting fuzzing, in this study, we propose a test pattern generation algorithm based on the concept of finite state machines. We apply graph analysis techniques to extract paths from finite state machines and use these paths to construct test patterns automatically. According to the proposal, fuzzing can be completed through inputting a regular expression corresponding to the test target. To evaluate the performance of our proposal, we conduct an experiment in identifying vulnerabilities of the input attributes in HTML5. According to the results, our approach is not only efficient but also effective for identifying weak validators in HTML5.
A Low Phase Noise Feedback Oscillator Based on SIW Bandpass Response Power Divider

A low phase noise X-band oscillator based on the bandpass response power divider in single-layer substrate integrated waveguide (SIW) technology is presented in this letter. The power divider is embedded in the SIW filter; therefore, lower insertion loss and more compact area size can be realized than those using the independent design of both components. To achieve better phase noise performance, transmission zeros are introduced by cross coupling through the resonant cavities to increase peak group delay. In addition, by placing external feeding at the center of cavity edge, the second harmonic can be suppressed efficiently. The measured results verify the performance of the proposed bandpass response power divider and show that the phase noise of the oscillator can achieve −143.3 dBc/Hz at 1-MHz offset frequency.
Clinical Experience of Long-Term Transdermal Treatment with Nitric Oxide Donor for Women with Preeclampsia

Isosorbide dinitrate (ISDN), a nitric oxide donor, was applied transdermally for 4–16 days to 4 preeclamptic women with oligohydramnios, intrauterine fetal growth retardation (IUGR), and elevated resistance of blood flow in the uterine arteries. Pulsed Doppler ultrasonography revealed immediate and drastic improvement of pulsatility index (PI) of uterine arteries following treatment with ISDN. The average PI in uterine arteries of the 4 patients was reduced to approximately 67% of that of the untreated state. In 2 patients the amniotic fluid gradually increased over a few days which suggested improvement of fetoplacental circulation during administration of ISDN. This study suggests that long-term transdermal ISDN is an effective therapy, at least in a portion of preeclamptic women, to avoid maternal hypertension, fetal distress, oligohydramnios, and IUGR, and consequentially to prolong the gestational period.
Mitochondrial genome of the blackfin tuna Thunnus atlanticus Lesson, 1831 (Perciformes, Scrombidae)

Abstract Blackfin tuna, Thunnus atlanticus is a widespread epipelagic oceanic species in the western Atlantic. So far the mitochondrial genome of this species remained unknown, although the mitogenomes of all congeners are known. The mitochondrial genome encodes for 13 proteins, 21 tRNAs, 2 ribosomal RNAs and the gene synteny is conserved with other previously reported mitogenomes of tunas.
Neurobiological Commonalities and Distinctions Among Three Major Psychiatric Diagnostic Categories: A Structural MRI Study

BACKGROUND Schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD) are distinct diagnostic categories in current psychiatric nosology, yet there is increasing evidence for shared clinical and biological features in these disorders. No previous studies have examined brain structural features concurrently in these 3 disorders. The aim of this study was to identify the extent of shared and distinct brain alterations in SZ, BD, and MDD. We examined gray matter (GM) volume and white matter (WM) integrity in a total of 485 individuals (135 with SZ, 86 with BD, 108 with MDD, and 156 healthy controls [HC]) who underwent high-resolution structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) at a single site. RESULTS Significant 4-group (SZ, BD, MDD, and HC groups) differences (P < .05, corrected) in GM volumes were found primarily in the paralimbic and heteromodal corticies. Post hoc analyses showed that the SZ, BD, and MDD groups shared GM volume decreases in 87.9% of the total regional volume with significant 4-group differences. Significant 4-group differences in WM integrity (P < .05 corrected) were found in callosal, limbic-paralimbic-hetermodal, cortico-cortical, thalamocortical and cerebellar WM. Post hoc analyses revealed that the SZ and BD groups shared WM alterations in all regions, while WM alterations were not observed with MDD. CONCLUSIONS Our findings of common alterations in SZ, BD, and MDD support the presence of core neurobiological disruptions in these disorders and suggest that neural structural distinctions between these disorders may be less prominent than initially postulated, particularly between SZ and BD.
Efficacy of Radiation Therapy for the Treatment of Sialocele in Dogs

Background Sialocele is a collection of saliva that has leaked from a damaged salivary gland or duct and is surrounded by granulation tissue. Surgery is the recognized first‐line treatment. Recurrence rate after surgery is 5–14%. Salivary gland tissue is very sensitive to radiation therapy (RT). Hypothesis/Objectives Radiation therapy will be useful for the treatment of sialocele. The aims were to characterize response rate and clinical course of dogs with sialocele treated with RT and to determine a starting dose for clinical use. Animals Eleven dogs with sialocele. Methods Retrospective study of response and outcome after RT. Results All dogs had cervical sialocele. Seven dogs (63.6%) were treated with 3 weekly fractions of 4 Gray (Gy); (total dose, 12 Gy). Three dogs (27.3%) received 4 fractions of 4 Gy (16 Gy) and 1 dog received 5 fractions of 4 Gy (20 Gy) on a Monday‐Wednesday‐Friday schedule. Six dogs (54%) achieved a complete response (CR), and 5 dogs (45%) achieved a partial response (PR). Three dogs had progression of their sialocele 2, 3, and 9 months after RT; all three had received 12 Gy initially and 2 received 2 additional fractions of 4 Gy (cumulative total dose, 20 Gy) and subsequently achieved remission for >2 years. Conclusions and Clinical Importance Radiation therapy is useful for the treatment of recurrent sialocele refractory to surgical management and a minimum total dose of 16 or 20 Gy in 4 Gy fractions appears effective.
Assignment of the CD47 gene to pig chromosome band 13q42→1/2q46 with somatic cell hybrids

CD47 is a integrin-associated protein originally discovered as a plasma membrane molecule that co-purified with the integrin ·vs3 from leukocytes and placenta (Brown et al., 1990). CD47 is an unusual member of the immunoglobulin (Ig) superfamily of membrane proteins, with a single IgV-like domain at its N-terminus, a highly hydrophobic stretch with five membrane-spanning segments and an alternatively spliced cytoplasmic C-terminus ranging in length from 3 to 36 amino acids (Schwartz and Baron, 1999). In human, CD47 is a receptor for thrombospondin family members, a ligand for the transmembrane signaling protein SIRP· and a component of a supramolecular complex containing specific integrins, heterotrimeric G proteins and cholesterol (Brown and Frazier, 2001). Mouse, rat, porcine and bovine CD47 molecules have been cloned and show about 70% overall amino acid identity with the human molecule suggesting that this gene might play a similar role in different species. Materials and methods
BIRC6 Targeting as Potential Therapy for Advanced, Enzalutamide-Resistant Prostate Cancer

Purpose: Enzalutamide resistance has emerged as a major problem in the management of castration-resistant prostate cancer (CRPC). Research on therapy resistance of CRPCs has primarily focused on the androgen receptor pathway. In contrast, there is limited information on antiapoptotic mechanisms that may facilitate the treatment resistance. The inhibitor of apoptosis proteins (IAP) family is well recognized for its role in promoting treatment resistance of cancers by inhibiting drug-induced apoptosis. Here, we examined whether BIRC6, an IAP family member, has a role in enzalutamide resistance of CRPCs and could provide a therapeutic target for enzalutamide-resistant CRPC. Experimental Design: Use of enzalutamide-resistant CRPC models: (i) the transplantable, first high-fidelity LTL-313BR patient-derived enzalutamide-resistant CRPC tissue xenograft line showing primary enzalutamide resistance, (ii) MR42D and MR49F CRPC cells/xenografts showing acquired enzalutamide resistance. Specific BIRC6 downregulation in these models was produced using a BIRC6-targeting antisense oligonucleotide (ASO-6w2). Gene expression was determined by qRT-PCR and gene expression profiling. Molecular pathways associated with growth inhibition were assessed via gene enrichment analysis. Results: Of eight IAPs examined, BIRC6 was the only one showing elevated expression in both enzalutamide-resistant CRPC models. Treatment with ASO-6w2 markedly suppressed growth of LTL-313BR xenografts and increased tumor apoptosis without inducing major host toxicity. Pathway enrichment analysis indicated that GPCR and matrisome signaling were the most significantly altered pathways. Furthermore, ASO-6w2 inhibited expression of prosurvival genes that were upregulated in the LTL-313BR line. Conclusions: BIRC6 targeting inhibited the growth of enzalutamide-resistant CRPC models and may represent a new option for clinical treatment of advanced, enzalutamide-resistant prostate cancer. Clin Cancer Res; 23(6); 1542–51. ©2016 AACR.
Cuckoo Search Optimization Metaheuristic Adjustment

Hard optimization problems that cannot be solved within reasonable time by standard, mathematical, deterministic methods are of great practical interest. Metaheuristics inspired by nature were recently successfully used for such problems. These metaheuristics are based on random Monte-Carlo search guided by simulation of some nature intelligence, especially evolution and swarm intelligence. One of the latest swarm intelligence algorithms is the Cuckoo Search Algorithm which has not yet been investigated thoroughly. For all such nature inspired algorithms fundamental issue is balance between use of good found solutions (exploration) and investigation of new areas of the search space in order to avoid being trapped in local minima (exploration). Specific of the Cuckoo Search Algorithm is exploitation/exploration based on Lévi flight i.e. combination of short and long steps according to Lévi distribution with infinite mean and variance. This plenary lecture concentrates on investigation of the Cuckoo Search Algorithm parameters adjustment and specifically sensitivity to Lévi distribution parameters. Key-Words: Cuckoo search algorithm, metaheuristic optimization, swarm intelligence, nature inspired
Characterisation of the biofouling community on a floating wave energy device

Abstract Wave energy devices are novel structures in the marine environment and, as such, provide a unique habitat for biofouling organisms. In this study, destructive scrape samples and photoquadrats were used to characterise the temperate epibenthic community present on prototypes of the Pelamis wave energy converter. The biofouling observed was extensive and diverse with 115 taxa recorded including four non-native species. Vertical zonation was identified on the sides of the device, with an algae-dominated shallow subtidal area and a deeper area characterised by a high proportion of suspension-feeding invertebrates. Differences in species composition and biomass were also observed between devices, along the length of the device and between sampling dates. This research provides an insight into the variation of biofouling assemblages on a wave energy device as well as the potential technical and ecological implications associated with biofouling on marine renewable energy structures.
Two-probe STM experiments at the atomic level

Direct characterization of planar atomic or molecular scale devices and circuits on a supporting surface by multi-probe measurements requires unprecedented stability of single atom contacts and manipulation of scanning probes over large, nanometer scale area with atomic precision. In this work, we describe the full methodology behind atomically defined two-probe scanning tunneling microscopy (STM) experiments performed on a model system: dangling bond dimer wire supported on a hydrogenated germanium (0 0 1) surface. We show that 70 nm long atomic wire can be simultaneously approached by two independent STM scanners with exact probe to probe distance reaching down to 30 nm. This allows direct wire characterization by two-probe I–V characteristics at distances below 50 nm. Our technical results presented in this work open a new area for multi-probe research, which can be now performed with precision so far accessible only by single-probe scanning probe microscopy (SPM) experiments.
Assignment1 of the hepatocyte nuclear factor 3 genes to rat chromosome bands 6q23→q24 (alpha: Hnf3a), 3q41 (beta: Hnf3b) and 1q21→q22 (gamma: Hnf3g) by in situ hybridization

The Hnf3 genes encode liver-enriched transcription factors which were shown to bind to the transthyretin and ·1-antitrypsin gene promoters (Lai et al., 1991; Costa et al., 1989). They are expressed early during development and appear to be involved in regulation of endodermal differentiation (Ang et al., 1993). The Hnf3·, -ß and -Á genes were previously mapped on mouse chromosomes 12, 2 and 7 and on human chromosomes 14q12→q13, 20p11 and 19q13.2→q4 (Avraham et al., 1992; Mincheva et al., 1996). Using fluorescence in situ hybridization (FISH), we assigned the Hnf3 genes to rat chromosome regions 6q23→q24 (Hnf3a), 3q41 (Hnf3b) and 1q21→q22 (Hnf3g). These results extend the homology between the chromosomes carrying the Hnf3 genes. Materials and methods