Miracle-dz/UniFAR-FTUs huggingface dataset:
The solar potential of Auckland

This research investigates the maximum potential energy that can be made available by efficiently installing photovoltaic (PV) systems on buildings throughout a city, from the central business district (CBD) out to low density suburbs. The purpose of this is to evaluate the contribution that electricity from PVs can make to reduce the electricity load of a city, supply the needs of a mixture of building types, reduce peak electricity demand and contribute towards the charging of electric vehicles (EVs). Having established the maximum potential, intermediate stages in PV penetration can be backcasted. The results indicate that low dense suburbia is not only the most efficient collector of solar energy but that enough excess electricity can be generated to power daily transport needs of suburbia and also contribute to peak daytime electrical loads in the city centre. This challenges conventional thinking that suburbia is energy inefficient. While a compact city may be more efficient for the internal combustion engine vehicles, a dispersed city is more efficient when distributed generation of electricity by PVs is the main energy source and EVs are the means of transport.
Sensor for the Detection of Protective Coating Traces on Boron Steel With Aluminium–Silicon Covering by Means of Laser-Induced Breakdown Spectroscopy and Support Vector Machines

Welding processes are one of the most widespread industrial activities, and their quality control, in both online and offline methods, is an important area of research. In the particular process of laser welding of boron steel with aluminium-silicon covering in the automotive industry, one problem is the presence of residual traces from the protective antioxidant coating, an aluminium-silicon alloy, which can result in a significant reduction of the welding seam strength. This work proposes a sensor system based on a laser induced breakdown spectroscopy (LIBS) setup to detect and discriminate aluminium residues in the welding area without destroying the sample before the welding procedure. A spectral algorithm based on support vector machines (SVMs) is used as a classifier to automatically identify areas with aluminum presence.
Speech signal enhancement through wavelet domain MMSE filtering

A new speech enhancement system that combine robust signal enhancement and minimum signal distortion is proposed in this paper. The proposed method introduces frequency depended, parametric, MMSE filtering techniques that involve wavelet packets. Voice activity detection (VAD) is used to further distinguish speech from noise and help to adaptively remove noise components from color noise eruptive noisy speech, while perceptual criteria is also taken into account. Experimental results and objective quality measurement test results validate the proposed speech enhancement system and illustrate the benefit of the proposed wavelet domain MMSE filtering as an excellent speech enhancement method to provide sufficient noise reduction and good intelligibility and perceptual quality, without causing considerable signal distortion and musical background noise method.
Computed tomography diagnosis of eight dogs with brain infarction.

OBJECTIVE Medical records of eight dogs presenting with acute onset of neurological signs and a diagnosis of brain infarction as determined by computed tomography (CT) imaging were reviewed. DESIGN Retrospective single-centre case review. RESULTS Ischaemic infarction in the territory of the rostral cerebellar artery was identified in three spaniel-breed dogs. All cerebellar infarcts were non-haemorrhagic. Telencephalic infarcts were identified in five dogs, in the territories of the middle cerebral artery (2/5) and rostral cerebral artery (3/5). One of these dogs had an ischaemic infarction, but all other infarctions appeared haemorrhagic. All dogs were geriatric (≥ 8 years old), with concurrent medical conditions identified in six dogs. One dog was euthanased after diagnosis because of the severity of its neurological signs and one dog was euthanased as a result of associated renal disease 2 months after diagnosis. Six dogs were alive at least 1 year after diagnosis. CONCLUSIONS CT is useful in the diagnosis of cerebrovascular accident in dogs, which can present as a spectrum of images with early changes in attenuation and subtle mass effects detected after infarction. CT is particularly sensitive for detecting haemorrhagic infarction, but under-represent ischaemic and lacunar infarctions when compared with MRI.
Comparison of Ophthalmic Sponges for Measurements of Immune Markers from Cervical Secretions

ABSTRACT Measurements of cervical immunity are important for evaluating immune responses to infections of the cervix and to vaccines for preventing those infections. Three ophthalmic sponges, Weck-Cel, Ultracell, and Merocel, were loaded in vitro with interleukin-1β (IL-1β), IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-15, IL-18, gamma interferon (IFN-γ), granulocyte-macrophage colony-stimulating factor (GM-CSF), immunoglobulin A (IgA), or IgG, and sponges were extracted and evaluated for total recovery by enzyme-linked immunosorbent assay (ELISA). There was excellent (>75%) recovery for all immune markers from all three devices except for IL-6, which was poorly recovered (<60%) for all sponge types, IFN-γ, which was poorly recovered from both Weck-Cel and Ultracell sponges but was completely recovered from Merocel sponges, and IL-4, which was poorly recovered from Weck-Cel sponges but was completely recovered from Ultracell or Merocel sponges. We then compared the absolute recovery of selected markers (IL-10, IL-12, IgG, and IgA) from cervical secretion specimens collected from women using each type of sponge. There were no significant differences in the recoveries of IL-10, IL-12, and IgG from cervical specimens collected by any type of ophthalmic sponge, but there was reduced IgA recovery from Merocel sponges. However, the variability in these measurements attributable to sponge types (1 to 3%) was much less than was attributable to individuals (45 to 72%), suggesting that differences in sponge type contribute only in a minor way to these measurements. We infer from our data that the three collection devices are adequate for the measurements of IL-1β, IL-2, IL-5, IL-12, IL-15, IL-18, and IgG. Merocel may be a better ophthalmic sponge for the collection of cervical secretions and measurements of IL-4, IL-8, IL-10, GM-CSF, and IFN-γ, but our data from clinical specimens, not in vitro-loaded sponges, suggested the possibility of reduced recovery of IgA. These findings require confirmation.
Biomarker response and therapy prediction in renal denervation therapy – the role of MR-proadrenomedullin in a multicenter approach

Abstract Background: Renal denervation has been proposed as a therapeutic option in patients with resistant hypertension. Circulating blood borne biomarkers might be helpful to identify individuals responding to RDN therapy. MR-proADM is a strong prognostic marker in patients with cardiovascular disease. The aim of this multicenter study was to evaluate the effect of RDN on MR-proADM concentrations. Methods and results: We measured MR-proADM, BNP, and MR-proANP in 110 patients before and after RDN in a multicenter setting. All patients were followed up after 1 and 6 months by office and ambulatory blood pressure (BP) measurements. The mean office BP decreased from 165/89 to 152/87 mmHg 6 months after RDN (systolic: p < 0.001; diastolic: ns), the responder-rate was 74%. Intriguingly MR-proADM concentrations increased from 0.66 to 0.69 nmol/L (p < 0.001) and were significantly associated with reduction of systolic office BP after 6 months in multivariate analyses (coefficient −0.0018, p < 0.001). In therapy-responders MR-proADM concentrations showed a significantly higher increase over time (coefficient 0.0105, p < 0.05), as compared to non-responders. There were no significant differences in BP change for individuals with low and high baseline MR-proADM (BP-Delta low MR-proADM −23/−4 mmHg vs. high MR-proADM −24/−5 mmHg). The natriuretic biomarkers BNP and MR-proANP did not change significantly after 6 months. Biomarkers at baseline were not able to predict for therapy-responder. Conclusion: In patients undergoing RDN, baseline measurements of various biomarkers had no prognostic use for therapy success in this short time follow-up period in a multicenter approach. Intriguingly, MR-proADM showed a significant association with BP reduction after 6 months.
A COM-Based Decision Tree Model Integrated with GIS for Assessment of Soil Heavy Metals Pollution

A COM-based decision tree model was integrated with Geographical Information Systems (GIS) to assess the soil Cu pollution in Fuyang, Zhejiang, China. The integration of the decision tree model with ArcGIS Engine 9.2 using a COM implementation in Microsoft® Visual Basic 6.0 provided an approach for assessing the spatial distribution of soil Cu content with high predictive accuracy. The decision tree model (CART) accuracy of assigning samples to the right Cu classes is 85.37% and 82.00%, the Kappa coefficient is 0.8182 and 0.7698 respectively for training data and test data. This is a great improvement comparing with ordinary Kriging method for the spatial autocorrelation of the study area severely destroyed by human activities. The integrated approach also allows for relatively easy, fast, and cost-effective estimation of spatially distributed soil heavy metals pollution. The methods and results described in this study are also valuable for understanding the relationship between heavy metals pollution risk and environmental factors.
A Pragmatic Approach to Neurolinguistics: Requests (Re)Considered

In recent years there has been a series of studies in the field of neurolinguistics and neuropsychology investigating the comprehension and interpretation of indirect requests predominantly in right brain-damaged individuals. Although the findings of these studies seem to suggest that indirect requests may be perceived, comprehended, judged, or interpreted differently by some right brain-damaged individuals, until today no coherent picture pertaining to the description of the phenomenon under investigation has emerged. One reason for this dissatisfying situation may be that the features contributing to the interpretation of a request in terms of its level of directness have not been sufficiently investigated. In addition, the stimuli on which the experiments were based are not always clear-cut or specific if viewed within the framework of pragmatic theory. The article provides an introduction to some aspects of pragmatic theory and discusses five major studies on request comprehension in brain-damaged patients with reference to the components relevant to the realization of requests. Finally, suggestions concerning future research are made.
Deciphering the native GABAA receptor: Is there hope?

The bewildering number of GABAA receptor subunits, their regionally dependent expression in the brain, and their supernumerary expression in single cells present major challenges in studying the function of native GABAA receptors. Which subunit combinations actually exist in native neurons? In this mini‐review, GABAA receptor subunit diversity is considered in light of using the wealth of “structure‐function” information gained from studying recombinant receptor to predict the subunit composition and functional properties of native GABAA receptors. © 1995 Wiley‐Liss, Inc.
Impulsivity and opioid drugs: differential effects of heroin, methadone and prescribed analgesic medication

Background. Previous studies have provided inconsistent evidence that chronic exposure to opioid drugs, including heroin and methadone, may be associated with impairments in executive neuropsychological functioning, specifically cognitive impulsivity. Further, it remains unclear how such impairments may relate of the nature, level and extent of opioid exposure, the presence and severity of opioid dependence, and hazardous behaviours such as injecting. Method. Participants with histories of illicit heroin use (n = 24), former heroin users stabilized on prescribed methadone (methadone maintenance treatment; MMT) (n = 29), licit opioid prescriptions for chronic pain without history of abuse or dependence (n = 28) and healthy controls (n = 28) were recruited and tested on a task battery that included measures of cognitive impulsivity (Cambridge Gambling Task, CGT), motor impulsivity (Affective Go/NoGo, AGN) and non-planning impulsivity (Stockings of Cambridge, SOC). Results. Illicit heroin users showed increased motor impulsivity and impaired strategic planning. Additionally, they placed higher bets earlier and risked more on the CGT. Stable MMT participants deliberated longer and placed higher bets earlier on the CGT, but did not risk more. Chronic opioid exposed pain participants did not differ from healthy controls on any measures on any tasks. The identified impairments did not appear to be associated specifically with histories of intravenous drug use, nor with estimates of total opioid exposure. Conclusion. These data support the hypothesis that different aspects of neuropsychological measures of impulsivity appear to be associated with exposure to different opioids. This could reflect either a neurobehavioural consequence of opioid exposure, or may represent an underlying trait vulnerability to opioid dependence.
The metabolic causes of slow relaxation in fatigued human skeletal muscle.

1. The relationship between slowing of relaxation and changes of intracellular pH and phosphorous metabolites has been examined in human skeletal muscle during the development of fatigue and subsequent recovery. Results obtained with normal subjects have been compared with those from a subject with myophosphorylase deficiency (MPD) who produced no H+ from glycolysis during exercise and therefore afforded the opportunity of assessing the role of H+ in the slowing of relaxation. 2. Subjects fatigued the first dorsal interosseous muscle in a stepwise fashion under ischaemic conditions, with intervals between the fatiguing contractions during which the relaxation rate was measured from brief tetanic contractions and the muscle phosphorous metabolites and pH were measured by nuclear magnetic resonance spectroscopy. 3. After 21 s maximal voluntary contraction under ischaemic conditions, relaxation in the MPD subject slowed to approximately 50% of the rate in the fresh muscle at a time when the intramuscular pH had not changed. This demonstrates that there is a mechanism causing slowing of relaxation that is independent of H+ accumulation. 4. The normal subjects showed a slow recovery of relaxation compared to the MPD subject when the circulation was restored. The main difference in the intracellular metabolite concentrations between MPD and normal subjects at this time was that, for the latter, the pH remained low (around 6.5) for at least 60 s after the circulation was restored. The results suggest that the slow recovery is a consequence of continuing acidosis, i.e. the existence of a pH‐dependent mechanism of slowing. 5. The existence of a pH‐dependent mechanism was further indicated by the fact that for the normal subjects, for a similar intracellular concentration of phosphocreatine, relaxation of the recovering muscle was approximately half that of the fatiguing muscle. This was at a time when the pH of the recovering muscle was 0.3‐0.4 units less than in the partially fatigued muscle. 6. The results show that in normal muscle there are at least two processes that lead to slow relaxation in fatigued muscle: one due to H+ accumulation, the other being independent of H+.
Drawing the Line: The Cultural Cartography of Utilization Recommendations for Mental Health Problems∗

In the 1990s, sociologists began to rethink the failure of utilization models to explain whether and why individuals accessed formal treatment systems. This effort focused on reconceptualizing the underlying assumptions and processes that shaped utilization patterns. While we have built a better understanding of how social networks structure pathways to care and how disadvantaged socio-cultural groups face substantial barriers to treatment, we have less understanding of the larger cultural context in which individuals recognize and respond to symptoms. Drawing from recent innovations in the sociology of culture, we develop the concept of “cultural mapping” to describe if and how individuals discriminate among different available sources of formal treatment. Using data from the 1996 Mental Health Module of the General Social Survey, we compare Americans' willingness to recommend providers in the general medical and specialty mental health sectors. The results indicate that, despite unrealistically high levels of endorsement, individuals do discriminate between providers based on their evaluation of the problem, underlying causes, and likely consequences. While perceived severity leads individuals to suggest any type of formal care, problems attributed to biological causes are directed to general or specialty medical providers (doctors, psychiatrists, and hospitals); those matching symptoms for schizophrenia or seen as eliciting violence are allocated to the specialty mental health sector (psychiatry, mental hospital); and those seen as being caused by stress are sent to nonmedical mental health providers (i.e., counselors). These findings help to explain inconsistencies in previous utilization studies, and they suggest the critical importance of maintaining a dialogue between medical sociology and the sociology of culture.
A Study on Influences of Gender Differences on Social Presence Features

With the increase in Internet-based sales, attracting and retaining online customers has become the most important part of running a successful business. In order to maintain customer loyalty, website designers should consider providing gender sensitized user experience as men and women have been known to have different perceptions of online shopping. Women tend to prefer shopping experience that creates connection with other humans. Online shopping experience, in general, can be perceived as lacking human warmth and sociability as it is devoid of interactions with other humans. However, to date, influence of social presence (interpreting human warmth and contact electronically) on e-Loyalty across genders has been relatively underexplored. In this research-in-progress paper, we present a research model to study the effects of gender differences on social presence cues in retail websites. As a part of future work, we plan to use survey methodology to analyze and validate the research model.
Glucose homeostasis in children with falciparum malaria: precursor supply limits gluconeogenesis and glucose production.

To evaluate glucose kinetics in children with falciparum malaria, basal glucose production and gluconeogenesis and an estimate of the flux of the gluconeogenic precursors were measured in Kenyan children with uncomplicated falciparum malaria before (n = 11) and during infusion of alanine (1.5 mg/kg.min; n = 6). Glucose production was measured by [6,6-2H2]glucose, gluconeogenesis by mass isotopomer distribution analysis of glucose labeled by [2-13C]glycerol. Basal plasma glucose concentration ranged from 2.1-5.5 mmol/L, and basal glucose production ranged from 3.3-7.3 mg/kg.min. Glucose production was largely derived from gluconeogenesis (73 +/- 4%; range, 52-93%). During alanine infusion, plasma glucose increased by 0.4 mmol/L (P = 0.03), glucose production increased by 0.8 mg/kg.min (P = 0.02), and gluconeogenesis increased by 0.8 mg/kg.min (P = 0.04). We conclude that glucose production in children with uncomplicated falciparum malaria is largely dependent on gluconeogenesis. However, gluconeogenesis is potentially limited by insufficient precursor supply. These data indicate that in children with falciparum malaria, gluconeogenesis fails to compensate in the presence of decreased glycogen flux to glucose, increasing the risk of hypoglycemia.
Craniofacial Wound Healing with Photobiomodulation Therapy

The fundamental pathophysiologic response for the survival of all organisms is the process of wound healing. Inadequate or lack of healing constitutes the etiopathologic basis of many oral and systemic diseases. Among the numerous efforts to promote wound healing, biophotonics therapies have shown much promise. Advances in photonic technologies and a better understanding of light-tissue interactions, from parallel biophotonics fields such as in vivo optical imaging and optogenetics, are spearheading their popularity in biology and medicine. Use of high-dose lasers and light devices in dermatology, ophthalmology, oncology, and dentistry are now popular for specific clinical applications, such as surgery, skin rejuvenation, ocular and soft tissue recontouring, and antitumor and antimicrobial photodynamic therapy. However, a less well-known clinical application is the therapeutic use of low-dose biophotonics termed photobiomodulation (PBM) therapy, which is aimed at alleviating pain and inflammation, modulating immune responses, and promoting wound healing and tissue regeneration. Despite significant volumes of scientific literature from clinical and laboratory studies noting the phenomenological evidence for this innovative therapy, limited mechanistic insights have prevented rigorous and reproducible PBM clinical protocols. This article briefly reviews current evidence and focuses on gaps in knowledge to identify potential paths forward for clinical translation with PBM therapy with an emphasis on craniofacial wound healing. PBM offers a novel opportunity to examine fundamental nonvisual photobiological processes as well as develop innovative clinical therapies, thereby presenting an opportunity for a paradigm shift from conventional restorative/prosthetic approaches to regenerative modalities in clinical dentistry.
Minocycline protects oligodendroglial precursor cells against injury caused by oxygen‐glucose deprivation

Ischemic brain injury is widely modeled in vitro with paradigms of oxygen‐glucose deprivation (OGD), which leads to cell death. The prevention and attenuation of brain injury by the tetracycline antibiotic minocycline has been attributed largely to suppression of microglial activation, but its benefits in oligodendrocyte cells have not been well characterized. Using primary cultures of rat oligodendroglial precursor cells (OPC) exposed to OGD, we investigated the direct effects of minocycline on the survival, proliferation, and maturation of oligodendroglial lineage cells. OGD for 2 hr caused a decrease in the total number of OPC and the amount of proliferating progenitors by 50%, which was attenuated by inclusion of minocycline. The reduced numbers of immature oligodendroglial cells at 72 hr and of mature oligodendrocytes at 120 hr after OGD were partially restored by minocycline. In OPC, OGD caused an increase of reactive oxygen species (ROS) and production of TUNEL‐positive cell numbers, which was abolished by minocycline. Minocycline preferentially increased the expression of superoxide dismutase under OGD but not in control OPC. Minocycline also prevented the OGD‐induced downregulation of the transcription factors Sox10 and Olig2 and of myelin‐specific genes 2′3′ cyclic nucleotide phosphodiesterase (CNP) and myelin basic protein (MBP) in response to OGD. These studies demonstrate direct protective actions of minocycline on oligodendroglial‐lineage cells, suggesting potential benefit in white matter injury involving OGD. © 2012 Wiley Periodicals, Inc.