Cytotoxic and antiviral properties of 4,4'-bis-aminoalkoxybiphenyls

Zanoza Svitlana O. , Bykova Tatiana I. , Lyakhov Sergey A. , Andronati Sergey A. , Zholobak Nadiya M. , Levandovskiy Igor A. Cytotoxic and antiviral properties of 4,4'-bis-aminoalkoxybiphenyls. Journal of Health Sciences. 2014;4(16):276-281. ISSN 1429-9623 / 2300-665X. DOI 10.5281/zenodo.21774 http://dx.doi. org/10.5281/zenodo.21774 https://pbn.nauka. gov.pl/works/597257 POL - index https://pbn.nauka. gov.pl/polindex/browse/article/article-7b456720-fdc3-40eb-b04d-ecbde3966e51 http://journal.rsw. edu.pl/index.php/JHS/article/view/2014%3B4%2816%29%3A276-281 The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014). © The Author (s) 2014; This article is published with open access at Licensee Open Journal Systems of Radom University in Radom, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 15.11. 2014. Revised 05.12. 2014. Accepted: 25.12. 2014. CYTOTOXIC AND ANTIVIRAL PROPERTIES OF 4,4'-BIS-AMINOALKOXYBIPHENYLS Svitlana O. Zanoza 1 , Tatiana I. Bykova 2 , Sergey A. Lyakhov 1 , Sergey A. Andronati 1 , Nadiya M. Zholobak 2 , Igor A. Levandovskiy 3 1 O.V. Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine, 86 Lustdorfska Doroga, 65080, Odesa, Ukraine. E-mail sa.zanoza@gmail.com 2 D.K. Zabolotny Institute of Microbiology and Virology of the NASU, 154D Acad. Zabolotny str. , 03680, Kyiv, Ukraine. E-mail bti77@ukr.net 3 Department of Organic Chemistry, National Technical University of Ukraine, Pr. Pobedy 37, 03056 Kyiv, Ukraine. E-mail lia@xtf.kpi. ua Summary Despite the high efficiency of the etiotropic antiviral drugs and antiviral vaccines they can lead to the selection of resistant mutant variants, initiate of evolutionary "arms race" [1] and pose a threat of the superinfections and epidemics. In this regard, the creation of means that enhance non-specific antiviral resistance is actual task and will be such in the future. The development of such agents – the functional analogues of amixyne (tilorone) – inducers of IFN type I is conducted in the past decades in O.V. Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine. As an inactive model compound 4,4'-bis-[2-(diethylamino)ethoxy]bi-phenyl was synthesized in 2005 and unexpectedly appeared as an active antiviral and interferon inductor [2]. In this regard, analogues of this compound is of considerable interest from the point of view of the structure-properties relationships. These substances (R-A-4DP4-A-R, R – amino group of different structure; A = -(CH 2 ) n O-, n = 2 - 6; 4BP4 - 4,4'-biphenyl) were synthesized via halogenoalkylation of 4,4-dioxybiphenyl with dihalogenoalkanes following with amino dehalogenation. Keywords : Cytotoxic; antiviral properties; aminoalkoksybiphenyls. References 1. Dawkins, R. The Blind Watchmaker / New York: W. W. Norton. – 1996 2. Bogorad-Kobelska O. S. , Zholobak N. M. , Dolga O. V. Diphenyl derivatives: cytotoxicity, antiviral and IFN-inducing activities in vitro // Int. J. Biomed. – 2011. – Vol. 1, № 3. – P. 153 – 157. 3. Saotome K. , Morita H. , Umeda M. Cytotoxicity test with simplified crystal violet staining method using microtitre plates and its application to injection drugs // Toxicol. In Vitro. – 1989. – V. 3, № 4. – P. 317 – 321. 4. Заноза С. О. , Мальцев Г. В. , Бикова Т. І. , Ляхов С. А. , Зубрицький М. Ю. , Андронаті С. А. Синтез і гемолітичні властивості похідних 4.4’-дигідроксибіфенілу // Ukrainica Bioorganica Acta. – 2014. – Т. 2. – с. 3 –9. 5. Богорад-Кобельська О. С. , Жолобак Н. М. , Олевінська З. М. , Співак М. Я. Активність похідних дифенілу на різних модельних системах вірус – клітина // Фізіологічний журнал. – 2012. – Т. 58, №1. – С. 36 – 42.