Miracle-dz/UniFAR-FTUs huggingface dataset:
Oxytocin improves cytological and histological profiles of vaginal atrophy in postmenopausal women

Objective To investigate if topical oxytocin can reverse vaginal atrophy, as assessed by cytological and histological examination of the vaginal mucosal epithelium, in postmenopausal women after 12 weeks of treatment as compared to placebo. Study design Sixty-eight postmenopausal women diagnosed with vaginal atrophy were randomized for this multicenter, double-blinded, placebo-controlled trial. Thirty-three women received 600 IU vagitocin, an oxytocin containing gel, and 35 women received a placebo gel intravaginally. The dose was 600 IU daily for the first two weeks and thereafter 600 IU twice a week for 10 weeks. All participant women underwent four visits and a subgroup of 20 women had a further fifth visit. Vaginal smears for cytological evaluation were collected at all visits. Vaginal biopsies were taken in 20 women before and after 12 weeks of treatment for histological analysis. In these women a vaginal smear was also collected after 14 weeks. Results The increase in the percentage of superficial cells between 0 and 2 weeks was significantly greater after treatment with vagitocin in comparison with placebo (p = 0.04). The difference in the maturation value between 0 and 12 weeks was significantly higher in the vagitocin than in the placebo group (p = 0.01). The reduction in the scores of atrophy was according to the histological investigation significantly greater in the vagitocin group than in the placebo group at 12 weeks (p < 0.04). Conclusion Daily intravaginal treatment with vagitocin 600 IU improves expressions of vaginal atrophy as recorded by cytological investigation of vaginal smears and histological analysis of vaginal biopsies. Treatment twice weekly seems to be less effective regarding the increase in superficial cells.
Uni- and Bidirectional Flux Variation Loci Method for Analytical Prediction of Iron Losses in Doubly-Salient Field-Excited Switched-Flux Machines

Field-Excited Flux-Switching machines are doubly-salient machines with complex flux-density waveforms in the core. Hence, prediction of iron losses is difficult. In this article, we propose a method to determine flux loci in iron parts in an analytical manner, accounting for bidirectional field in back-irons of stator and rotor. The analytical model for flux-density prediction in the core at no-load was first validated with 2D FE simulations. Then measured iron losses on a prototype machine were used to calibrate an iron loss model. It was shown that in FE-SF machines rotor iron losses are not negligible and represent 28% of total iron losses. This model could be advantageously used in a design optimization procedure.
Gait planning of biped robot based on feed-forward compensation of gravity moment

To improve the walking stability of biped robot, the adjusting angle is added to the ankle joint for eliminating the lateral disequilibrium. Three dimensional linear inverted pendulum model(3D-LIPM) is applied for depicting the motion of the biped robot. The motions of the stance and swing leg have an influence on the height of center of mass(COM), which is verified by the computer simulation. The model of the pendulum is also established for analyzing key factors which lead to the unbalance of the biped robot in the lateral plane, and analyzing results can be used to optimize the gait data. The motion trajectory of the each joint of the biped robot is generated by using the cosine and cycloid functions. The landing velocity of the swing leg is set to zero, and the impact is effectively reduced. Based on the inertial measure unit(IMU), the horizontal posture of the foot is kept by adjusting the ankle motors of the stance leg, and the walk stability of the biped robot is greatly improved. The inverse solution for discrete points of the walking trajectory is obtained by a numerical iterative means, which can satisfy the requirement of the control cycle of 10ms. The walking test is implemented on the flat ground, and the biped robot can steady walk with the single stance phase of 3s, the double-stance phase of 2s and the step-length of 200mm. the experiment results prove that compensation means of the gravity moment is available for the walking gait of biped robot.
Nuclear transport factor 2 represents a novel cross‐reactive fungal allergen

Background: Ubiquitously occuring moulds are important allergenic sources known to elicit IgE‐mediated allergic diseases and to share cross‐reactive allergens. Limited information is available about the molecular structures involved in cross‐reactivity. We aimed to clone and characterize cross‐reactive mould allergens.
A comparison of dehydroepiandrosterone and 7-keto dehydroepiandrosterone with other drugs that modulate ethanol intake in rats responding under a multiple schedule

Dehydroepiandrosterone (DHEA), 7-keto DHEA, and several comparison drugs (ethanol, chlordiazepoxide, rauwolscine, and RO15-4513) were administered to male rats responding under a multiple schedule of food and ethanol presentation to determine their selectivity for decreasing ethanol-maintained responding. DHEA and 7-keto DHEA significantly decreased both ethanol-maintained and food-maintained responding, compared with the control, while also decreasing the blood ethanol concentration (BEC). Acute ethanol administration also decreased responding for both food and ethanol; however, ethanol-maintained responding was more potently decreased than food-maintained responding. BEC remained relatively stable after increasing ethanol doses. Among the other drugs tested, RO15-4513 was the most selective for decreasing ethanol-maintained responding compared with food-maintained responding, and it decreased BECs as ethanol-maintained responding decreased. The largest dose of rauwolscine significantly decreased responding for food, whereas it did not affect ethanol-maintained responding compared with the control. Low to intermediate doses of rauwolscine produced small, nonsignificant increases in ethanol-maintained responding and BECs. Chlordiazepoxide produced significant decreases in food-maintained responding and the dose of ethanol presented, but only at the highest dose tested. Although DHEA and 7-keto DHEA did not decrease ethanol-maintained responding as selectively as ethanol or RO15-4513 under the multiple schedule, these neurosteroids may be valuable pharmacological tools in the development of new treatments for alcohol abuse and dependence.
Outdoor camera calibration method for a GPS & camera based surveillance system

A reliable outdoor binocular camera calibration method for a multi-GPS (Global Positioning System) apparatuses and multi-cameras based surveillance system is introduced in this paper. Different to other system, the user needs our system to track the motion and estimate the shape of the selected vehicle in real time by our binocular cameras. So we implement our system by these steps below: 1) fixing a GPS apparatus in each vehicle to collect the location information. 2) Calibrating the interior and exterior parameters of the binocular cameras. 3) Computing the coordinate transform matrix between the GPS coordinate system and the camera coordinate system. 4) Using the GPS information to guide the binocular cameras to track the moving vehicle. To calibrate the binocular camera in an outdoor environment, we use the Scale Invariant Feature Transform (SIFT) descriptor to compute the features. The RANSAC matching technique is used to eliminate the mismatch point pairs. After that, we use an essential matrix based self-calibration technique to compute the camera parameter. Finally, we analyze the relationship between the blur affection level of the calibration image and our proposed method. Many experiment results have shown the robustness of our method.
5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) Effect on Glucose Production, but Not Energy Metabolism, Is Independent of Hepatic AMPK in Vivo *

Background: AMPK is implicated as the mediator of AICAR action on liver metabolism. Results: AICAR suppresses glucose production independent of AMPK. Regulation of mitochondrial function is AMPK-dependent. Conclusion: Nucleotide monophosphates rely on AMPK to regulate energy metabolism but not to suppress glucose production. Significance: Targeted AMPK activation will not lower glucose production in metabolic diseases but could improve hepatic energetics. Metabolic stress, as well as several antidiabetic agents, increases hepatic nucleotide monophosphate (NMP) levels, activates AMP-activated protein kinase (AMPK), and suppresses glucose production. We tested the necessity of hepatic AMPK for the in vivo effects of an acute elevation in NMP on metabolism. 5-Aminoimidazole-4-carboxamide 1-β-d-ribofuranoside (AICAR; 8 mg·kg−1·min−1)-euglycemic clamps were performed to elicit an increase in NMP in wild type (α1α2lox/lox) and liver-specific AMPK knock-out mice (α1α2lox/lox + Albcre) in the presence of fixed glucose. Glucose kinetics were equivalent in 5-h fasted α1α2lox/lox and α1α2lox/lox + Albcre mice. AMPK was not required for AICAR-mediated suppression of glucose production and increased glucose disappearance. These results demonstrate that AMPK is unnecessary for normal 5-h fasting glucose kinetics and AICAR-mediated inhibition of glucose production. Moreover, plasma fatty acids and triglycerides also decreased independently of hepatic AMPK during AICAR administration. Although the glucoregulatory effects of AICAR were shown to be independent of AMPK, these studies provide in vivo support for the AMPK energy sensor paradigm. AICAR reduced hepatic energy charge by ∼20% in α1α2lox/lox, which was exacerbated by ∼2-fold in α1α2lox/lox + Albcre. This corresponded to a ∼6-fold rise in AMP/ATP in α1α2lox/lox + Albcre. Consistent with the effects on adenine nucleotides, maximal mitochondrial respiration was ∼30% lower in α1α2lox/lox + Albcre than α1α2lox/lox livers. Mitochondrial oxidative phosphorylation efficiency was reduced by 25%. In summary, these results demonstrate that the NMP capacity to inhibit glucose production in vivo is independent of liver AMPK. In contrast, AMPK promotes mitochondrial function and protects against a more precipitous fall in ATP during AICAR administration.
ROTIFERS, AND OTHER AQUATIC INVERTEBRATES, FROM THE lARSEMANN HILLS, ANTARCTICA

Seventeen species of rotifer (11 Monogononta and six Bdelloidea) three tardigrades, two arthropods, as well as protozoans, a plathyhelminth and nematodes were found in 13 freshwater lakes in the Larsmann Hills, Antartctica
Growth inhibition due to complementation of transforming growth factor‐β receptor type II‐defect by human chromosome 3 transfer in human colorectal carcinoma cells

The transforming growth‐β receptor type II (TGF‐βRII) gene is one of the target genes of the DNA mismatch repair (MMR) defect. The human colorectal carcinoma cell line HCT116 has mutations in the hMLH1 gene and in the microsatellite region of the TGF‐βRII gene, both located on the short arm of chromosome 3. Introduction of the wild‐type hMLH1 gene on transferred human chromosome 3 restores many characteristics of MMR‐deficiency in HCT116. In this study, we determined whether transfer of chromosome 3 into HCT116 also complements the TGF‐βRII gene defect. We compared in vitro growth characteristics between HCT116 and HCT116 with a transferred chromosome 3 (HCT116 + ch3). The growth was suppressed in HCT116 + ch3 compared with parental HCT116. This suppression was abolished by frequent replacement with fresh medium, suggesting that the autocrine TGF‐β‐TGF‐βRII system may be responsible for growth suppression. To explore this possibility, we determined several characteristics essential for the autocrine system. We found that HCT116 + ch3 expresses wild‐type as well as mutated TGF‐βRII mRNA. In addition, phosphorylation of TGF‐βRI and growth inhibition were observed in HCT116 + ch3 but not in HCT116 by exposure to exogenous TGF‐β. The amount of TGF‐β1 in HCT116 + ch3 cultures was remarkably less than that in the HCT116, suggesting that TGF‐β produced by HCT116 + ch3 cells may be consumed by the cells. The conditioned medium from HCT116 cultures inhibits HCT116 + ch3 growth. This inhibition was neutralized by the anti‐TGF‐β antibody. Taken together, these results strongly suggest that the TGF‐βRII gene defect in HCT116 is complemented by a wild‐type gene on the transferred chromosome 3 and that HCT116 + ch3 gained the ability to respond to TGF‐β. Simultaneous complementation of defects of a responsible gene and a major target gene by the chromosome transfer is useful to prove the inactivated phenotypes acquired during colorectal tumorigenesis. © 2001 Wiley‐Liss, Inc.
PRIMARY CARE & HEALTH SERVICES SECTION Original Research Article Primary Care Monitoring of Long-Term Opioid Therapy among Veterans with Chronic Pain

Objective. To characterize long-term opioid pre- scribing and monitoring practices in primary care. Design. Retrospective medical record review. opioid, and 50 (30%) received two different opioids. Indicators of some form of potential opioid misuse were present in the medical records of 55 (33%) patients. Of the seven guideline-recommended opioid-monitoring practices we examined, the mean number documented within 6 months was 1.7 (stan- dard deviation (SD) 1.5). Pain reassessment was the most frequently documented process (N = 105, 52%), and use of an opioid treatment agreement was the least frequent (N = 19, 11%). Patients with indicators of potential opioid misuse had more documented opioid-monitoring processes than those without potential misuse indicators (2.4 vs 1.3, P < 0.001). After adjustment, potential opioid misuse was positively associated with the number of documented guideline-recommended processes (mean = 1.0 additional process, 95% confidence interval (CI) 0.4, 1.5). Conclusions. Guideline-recommended opioid man- agement practices were infrequently documented overall but were documented more often for higher risk patients who had indicators of potential opioid misuse. The relationship between guideline- concordant opioid management and high-quality care has not been established, so our findings should not be interpreted as evidence of poor quality opioid management. Research is needed to determine optimal methods of monitoring opioid therapy in primary care.
Direct electric in-wheel driving of a bicycle using reluctant motors

The paper deals with an overview regarding the implementation of individual urban transportation using reluctant motor driven electric bicycles. A particular case of Cluj- Napoca city is taken as reference. Study of opportunity, state of the art in the field of electrical driven bikes and a proposed solution for electric motorizing in this field are presented. Preliminary calculus and results are given.
The influence of organisational factors in small tourism businesses on the success of Internet marketing

Much of the previous research into the use of the Internet for marketing is either anecdotal in nature, conceptual or based on case studies. The focus of this study is to identify whether marketing objectives have an impact on the success of the use of the Internet for marketing of small tourism businesses tourism services. A hypothesis is developed and tested by making use of a large-scale empirical study. The results indicate that setting appropriate and realistic goals will have an impact on Internet marketing success.
DOLPHIN: an autonomous indoor positioning system in ubiquitous computing environment

Determining physical location of indoor objects is one of the key issues in development of context-aware applications in ubiquitous computing environments. This is mainly because context information obtained from sensor networks is meaningful only when the physical location of the context information source is determined. Recently, several indoor location information systems, such as Active Bat and Cricket, have been developed for precise indoor object localization. However, to provide accurate physical location tracking in large-scale space, those systems requires a lot of manual configuration for all the ultrasonic sensor nodes. To reduce configuration costs, we developed a new indoor positioning system called DOLPHIN. The DOLPHIN system consists of distributed wireless sensor nodes which are capable of sending and receiving RF and ultrasonic signals. These nodes are attached to various indoor objects. And using a novel distributed positioning algorithm in the nodes, DOLPHIN enables autonomous positioning of the objects with minimal manual configuration. This paper describes the design and implementation of the DOLPHIN system, and evaluates basic performance through several experiments in an indoor environment.
A vision‐based, 3D reconstruction technique for scanning electron microscopy: Direct comparison with atomic force microscopy

High‐resolution, detailed 3D reconstructions of biological specimens obtained from scanning electron microscopy stereo‐micrographs and proprietary software were compared with Tapping‐Mode AFM datasets of the same fields. The reconstruction software implements several original solutions including a neural adaptive point‐matching technique, the ability to build an irregular triangulated mesh rather than a regular orthogonal grid, and the ability to re‐map one of the original images exactly onto the reconstructed surface. The technique was applied to human nerve tissue to obtain 1,424 × 968‐pixel, texture‐mapped datasets, which were subsequently compared against 512 × 512‐pixel AFM datasets from the same viewfields. Accounting for the inherent differences of the two techniques, direct comparison revealed an excellent visual match. The correspondence was also quantified by calculating the cross‐correlation coefficient between corresponding altimetric profiles in SEM and AFM data, which consistently exceeded a figure of 0.9, with a rate of point mismatch in the order of 0.01%. Research is still underway to improve the robustness of the technique when applied to arbitrary images. Microsc. Res. Tech. 67:1–7, 2005. © 2005 Wiley‐Liss, Inc.
IN-VITRO ANTIBACTERIAL ACTIVITY OF ANOGEISSUS LEIOCARPUS DC ( STEM BARK ) EXTRACTS AGAINST ESCHERICHIA COLI AND STAPHYLOCOCCUS AUREUS 1

Antibacterial secreening of ethanolic, aqueous and chloroform extracts of Anogeissus leiocarpus was carried out against Escherichia coli and Staphylococcus aureus. The result shows that all the extract exhibited antibacterial activity against the test organisms with the exception of the lowest concentration of aqueous and chloroform extract. Ethanolic extracts at concentration of 300ug/ml showed greater activity against E. coli (16mm) and Staphylococcus aureus (15mm) than the remaining extracts. Activity was greater against E.coli in response to all fractions (16mm, 15mm, and 12mm respectively at the highest concentrations than the Staphylococcus aureus (14mm, 11mm, and 9mm). Results showed that, antibacterial activity of the extracts was dose dependant. Augmentin and gentamicine were the antibiotics used as the positive control discs against the test organisms. These antibiotics showed greater activity than the crude extracts respectively. The bioactive compounds detected in the extracts were alkaloids, tannins, flavonoids, glycosides and saponins. As there is growing interest in obtaining sample of plant materials with a view to explore the possibilities for medicinal products and in addition the current global upsurge of bacterial resistance to antibacterial drugs, the plant may be used as promising candidate for drug development.
Study and analysis of Social network Aggregator

Organizing contacts, friends, sharing thoughts, emotions searching content and data are the basic means that a social networking site provides. By sharing, and managing content the users form a social network for example, Facebook, Linkedin, twitter, Orkut, etc. A user may exist on several different social networking sites and the problem to maintain the account on these networks prevails. This brings us to define a Social network aggregation i.e. collecting the social content from different social networks and integrate it at a single location/site. It is an attempt to organize a user's social networking experience as whole. This paper gives a review on different Social network Aggregators and issues in integrating social network. Exposing criminal behaviours in e-commerce, computer intrusions identification, detecting health problems, analysing satellite images.
Differentiating between Verbal and Spatial Encoding using Eye-Movement Recordings

Visual information processing is guided by an active mechanism generating saccadic eye movements to salient stimuli. Here we investigate the specific contribution of saccades to memory encoding of verbal and spatial properties in a serial recall task. In the first experiment, participants moved their eyes freely without specific instruction. We demonstrate the existence of qualitative differences in eye-movement strategies during verbal and spatial memory encoding. While verbal memory encoding was characterized by shifting the gaze to the to-be-encoded stimuli, saccadic activity was suppressed during spatial encoding. In the second experiment, participants were required to suppress saccades by fixating centrally during encoding or to make precise saccades onto the memory items. Active suppression of saccades had no effect on memory performance, but tracking the upcoming stimuli decreased memory performance dramatically in both tasks, indicating a resource bottleneck between display-controlled saccadic control and memory encoding. We conclude that optimized encoding strategies for verbal and spatial features are underlying memory performance in serial recall, but such strategies work on an involuntary level only and do not support memory encoding when they are explicitly required by the task.
Varactor-loaded dual-polarized unit-cell for reconfigurable reflectarrays

This paper presents a novel varactor-load radiating element for reconfigurable reflectarray. The unit-cell for reflectarray consists of patch groups integrated with varactors and the circuitry for DC biasing voltage control. The proposed unit-cell can generate the dual-polarized tunable reflection thanks to the wide reflected phase tuning range, resonant frequencies shift and the symmetry in the structure. The performance has been evaluated by full wave simulations, and the detailed results are demonstrated and discussed.
Detection of buried inhomogeneous elliptic cylinders by a memetic algorithm

The paper studies the application of a global optimization procedure to the detection of buried inhomogeneities. The object inhomogeneities are schematized as multilayer infinite dielectric cylinders with elliptic cross sections. An efficient recursive analytical procedure is used for the forward scattering computation. A functional is constructed in which the field is expressed in a series solution of Mathieu functions. Starting with the input scattered data, the iterative minimization of the functional is performed by a new optimization method called memetic algorithm.