Miracle-dz/UniFAR-FTUs huggingface dataset:
INTELLIGENT DISTURBANCE DIAGNOSIS IN POWER TRANSFORMERS BASED ON THE WAVELET TRANSFORM AND SUPPORT VECTOR MACHINE

— This paper proposes a method based support vector machine and wavelet transform in order to discriminate diﬀerent disturbances in power transformers appropriately, such as internal and external faults, and transformer energizations. The proposed method recreates the conventional diﬀerential function using a disturbance detector, by means of the energies of the wavelet coeﬃcients, which enables the support vector machine (SVM)-based diﬀerential phase functions. Furthermore, the proposed method can work in conjunction with other system protections by sending warning signals, for example in external fault conditions of the transformer, so it makes the protection system more reliable and intelligent. Several events were simulated in the alternative transient program, such as external and internal faults, turn-to-turn and turn-to-ground fault with variations of fault resistance, fault inception angle, and fault type parameters, as well as transformer energizations. The method presented better success rate and a faster trip in the internal fault detection then the conventional diﬀerent protection.
Polydopamine-Based “Four-in-One” Versatile Nanoplatforms for Targeted Dual Chemo and Photothermal Synergistic Cancer Therapy

The development of versatile nanoscale drug delivery systems that integrate with multiple therapeutic agents or methods and improve the efficacy of cancer therapy is urgently required. To satisfy this demand, polydopamine (PDA)-modified polymeric nanoplatforms were constructed for the dual loading of chemotherapeutic drugs. The hydrophobic anticancer drug docetaxel (DTX) was loaded into the polymeric nanoparticles (NPs) which were fabricated from the star-shaped copolymer CA-PLGA. Then DTX-loaded NPs were coated with PDA, followed by conjugation of polyelethyl glycol (PEG)-modified targeting ligand aptamer AS1411(Apt) and adsorption of the hydrophilic anticancer drug doxorubicin (DOX). This “four-in-one” nanoplatform, referred to as DTX/NPs@PDA/DOX-PEG-Apt, demonstrated high near-infrared photothermal conversion efficiency and exhibited pH and thermo-responsive drug release behavior. Furthermore, it was able to specifically target MCF-7 human breast carcinoma cells and provide synergistic chemo-photothermal therapy to further improve the anticancer effect both in vitro and in vivo, providing a novel promising strategy for cancer therapy.
Finite-Time Coverage Control for Multiagent Systems With Unidirectional Motion on a Closed Curve

The finite-time coverage control problem for networked mobile agents with continuous-time dynamics and unidirectional motion constraint on a closed curve is addressed in this article. The objective is to minimize a coverage cost function in finite time which characterizes the largest arrival time from the multiagent system to any point on the curve. Low gain feedback is employed to design the distributed coverage control laws for the agents with different input constraints due to their limited movement capabilities. An upper bound on each low gain is also provided by showing that the distance between the neighboring agents is always lower and upper bounded. Under the proposed control laws, the networked mobile agents can be driven to the optimal configuration, minimizing the coverage cost function in finite time. Due to the unidirectional motion of the agents, there exists at least one agent which remains static throughout the coverage task. As a result, a less conservative upper bound on the low gains is derived, which provides the possibility of better convergence rates of the proposed coverage control laws.
Lack of a significant legacy effect of baseline blood pressure 'treatment naivety' on all-cause and cardiovascular mortality in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.

OBJECTIVES To investigate legacy effects at 14-year follow-up of all-cause and cardiovascular disease (CVD) mortality in 'treatment-naive' or 'previous treatment' groups based on blood pressure (BP)-lowering treatment status at baseline. METHODS A post-hoc observational study of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. We excluded participants with a previous history of CVD events. Cox proportional hazard model and 95% confidence interval were used to estimate the effects of treatment naive on mortality outcomes. Moreover, a subgroup analysis by estimated 10-year Framingham risk score was performed. RESULTS In multivariable models adjusting for baseline and in-trial characteristics (BP values and number of BP medications as time-dependent variables), there was no statistically significant difference in 5 and 14-year all-cause mortality with a hazard ratio of 0.93 (95% confidence interval 0.80-1.09) and hazard ratio 0.95 (0.88-1.03) and in 5 and 14-year CVD mortality hazard ratio 0.94 (0.72-1.23) and hazard ratio 0.93 (0.80-1.08). In subgroup by absolute CVD risk, no heterogeneity of the association between treatment naive and short-term or long-term all-cause or CVD mortality were found. All comparisons are between the treatment-naive and previous treatment groups. CONCLUSION Physicians are concerned about 'legacy effects' of not treating individuals with a BP of 140 mmHg or over and low absolute risk. When treatment intensification was taken into consideration in the primary prevention population in this study, no adverse legacy effect as a result of baseline BP 'treatment naivety' was evident in 14 years of follow-up. The nonsignificant associations were consistent across the CVD risk subgroups. However, the results may be biased due to unobserved residual confounding and therefore should be interpreted with caution.
Long Non-Coding RNAs and Related Molecular Pathways in the Pathogenesis of Epilepsy

Epilepsy represents one of the most common neurological disorders characterized by abnormal electrical activity in the central nervous system (CNS). Recurrent seizures are the cardinal clinical manifestation. Although it has been reported that the underlying pathological processes include inflammation, changes in synaptic strength, apoptosis, and ion channels dysfunction, currently the pathogenesis of epilepsy is not yet completely understood. Long non-coding RNAs (lncRNAs), a class of long transcripts without protein-coding capacity, have emerged as regulatory molecules that are involved in a wide variety of biological processes. A growing number of studies reported that lncRNAs participate in the regulation of pathological processes of epilepsy and they are dysregulated during epileptogenesis. Moreover, an aberrant expression of lncRNAs linked to epilepsy has been observed both in patients and in animal models. In this review, we summarize latest advances concerning the mechanisms of action and the involvement of the most dysregulated lncRNAs in epilepsy. However, the functional roles of lncRNAs in the disease pathogenesis are still to be explored and we are only at the beginning. Additional studies are needed for the complete understanding of the underlying mechanisms and they would result in the use of lncRNAs as diagnostic biomarkers and novel therapeutic targets.
Association between dietary fiber and endometrial cancer: a meta-analysis

Abstract To explore a potential relationship between dietary fiber consumption and risk of endometrial cancer (EC), eligible studies published up to 30 June 2018 were retrieved via computer searches and manual review of references. Random-effects models were used to calculate summary relative risk (RR) estimates based on contrasting high- and low-fiber intake values. Sensitivity analysis was conducted, and heterogeneity among study results was explored through stratified analyses by study design, geographic region, Newcastle-Ottawa Scale (NOS) score, impact factor, and adjustment for several confounders (age, body mass index, smoking, energy intake, and education). We extracted data from 16 studies (involving 6,563 cases). There was a significant association between dietary fiber intake and EC (RR = 0.86, 95% confidence interval [CI]: 0.78, 0.93). In stratified analysis, this trend was more pronounced in the case–control studies, and in studies conducted in the Americas and Asia. The relationship was further confirmed after adjusting for education level (RR = 0.74; 95% CI: 0.60, 0.88) and age (RR = 0.70; 95% CI: 0.57, 0.83), and NOS scores of 6 (RR = 0.81; 95% CI: 0.67, 0.95) and 7 (RR = 0.75; 95% CI: 0.62, 0.88). In conclusion, our meta-analysis revealed an inverse association between dietary fiber consumption and EC risk. Further efforts should be made to confirm these findings.
Left Atrial Thrombus on TransEsophageal Echocardiography: rationale and design of the LATTEE registry - the first multicenter project on the Scientific Platform of the "Club 30" of the Polish Cardiac Society.

1078 the risk of both left atrial (LA) thrombus and ischemic stroke.3‐5 Yet, some patients develop LA thrombus and experience thromboembolic events despite OAC.6‐9 The CHA2DS2‐VASc ‐RAF (conges‐ tive heart failure, hypertension, age ≥75 years, di‐ abetes mellitus, history of stroke or thromboem‐ bolism, vascular disease, age 65 to 74 years, fe‐ male sex, renal dysfunction, type of AF) score has been recently proposed to improve LA thrombus prediction in AF.9 The aim of the study is to assess the preva‐ lence of LA thrombus in real ‐world patients with AF or AFl referred for transesophageal echocardiography (TEE), to identify predictors Introduction Since its establishment 25 years ago, the “Club 30” of the Polish Cardiac Society has gathered young Polish scientists with mean‐ ingful achievements in cardiology.1 The “Club 30” Scientific Platform has been created to facilitate initiation of and participation in multicenter stud‐ ies among its users, and to promote integration of scientific community.2 Multicenter cooperation, empowered by the platform, results in an increase in the number of enrolled patients and, conse‐ quently, enhances research quality and chances for publication in high ‐profile journals. In patients with atrial fibrillation (AF) and atri‐ al flutter (AFl), oral anticoagulation (OAC) reduces Correspondence to: Agnieszka Kapłon ‐Cieślicka, MD, PhD, 1st Chair and Department of Cardiology, Medical University of Warsaw, ul. Banacha 1a, 02‐097 Warszawa, Poland, phone: +48 22 599 29 58, email: agnieszka.kaplon@gmail.com Received: August 5, 2019. Revision accepted: October 4, 2019. Published online: October 4, 2019. Kardiol Pol. 2019; 77 (11): 1078‐1080 doi:10.33963/KP.15011 Copyright by the Author(s), 2019 S H O R T C O M M U N I C A T I O N
Joint Online RUL Prediction for Multivariate Deteriorating Systems

Stochastic processes and filtering methods are popular tools for degradation modeling and online remaining useful life (RUL) prediction. However, most models are for one-dimensional degradation and various filtering methods can only handle observations from a single system. This paper studies joint online RUL prediction of multideteriorating systems with multisystem observations and measurement errors. A multivariate degradation model equipped with a batch particle filter is developed and built for characterizing multiple dependent performance deteriorations with measurement errors in each system. The batch particle filter is developed for simultaneous online parameter estimation and degradation state identification by leveraging multisystem observations. A numerical example and a case study are provided to demonstrate the proposed method. The results show that homogeneous multisystem observations from a population of multideteriorating systems can be jointly processed on-the-fly. Individualized online RUL prediction with improved precision for each system can be achieved through the joint online inference.
Evolutionary processes of melanomas from giant congenital melanocytic nevi

Melanoma can develop in a congenital melanocytic nevus (CMN). In fact, a large CMN is associated with a high risk of developing melanoma. Although melanomas arising from CMNs are thought to have a pathogenesis distinct from conventional melanomas, no studies have been conducted on the evolution or tumor heterogeneity of CMN melanomas. We applied multi‐region whole‐exome sequencing to investigate the clonal nature of driver events and evolutionary processes in CMNs and melanomas arising from CMNs. In two patients, we observed an independent subclonal evolution in cancerized fields of CMNs and chromosome 8q amplification in both melanomas arising from CMNs. The amplification of MYC, located in chromosome 8q, was correlated with the percentage of tumor cells expressing high levels of MYC protein detected in melanoma cells by immunohistochemistry. Our analysis suggests that each CMN cell may evolve sporadically and that amplification of MYC might be a key event for melanoma development in CMNs.
Genome Sequence of “Candidatus Nitrosocosmicus franklandus” C13, a Terrestrial Ammonia-Oxidizing Archaeon

“Candidatus Nitrosocosmicus franklandus” C13 is an ammonia-oxidizing archaeon (AOA) isolated from soil. Its complete genome is 2.84 Mb and possesses predicted AOA metabolic pathways for energy generation and carbon dioxide fixation but no typical surface layer (S-layer) proteins, only one ammonium transporter, and divergent A-type ATP synthase genes. ABSTRACT “Candidatus Nitrosocosmicus franklandus” C13 is an ammonia-oxidizing archaeon (AOA) isolated from soil. Its complete genome is 2.84 Mb and possesses predicted AOA metabolic pathways for energy generation and carbon dioxide fixation but no typical surface layer (S-layer) proteins, only one ammonium transporter, and divergent A-type ATP synthase genes.
A Short Paper on Testability of a SoC

The latest advances in semiconductor mix improvement accomplished assembling of expansive number of areas on a solitary chip Test organizing is an essential issue in System on-a-chip (SOC) test mechanization. Effective test masterminds minimize the general structure test application time, keep away from test asset clashes, and most outrageous power scrambling amidst test mode. For solid system onchip, the circuit ought to be without fault since a solitary blame is likely going to make the entire chip vain. Finding the obstructions and utilization of helpful measures for same chip would diminish the running cost of the structure. The remarkable move toward test cost emergency, where semiconductor test costs start to approach or beat in more expenses has driven test organizers to apply new reactions for the issue of testing System-On-Chip (SoC) masterminds containing different IP (Intellectual Property) centers. since it is not yet possible to apply non particular test structures to an IP focus inside a SoC, the progress of different close frameworks, and the landing of new industry measures, for instance, IEEE 1500 and IEEE 1450.6, may begin to change this condition. This paper looks rules and at several systems at present utilized by SoC tests engineers [14].
Understanding barriers and facilitators to therapeutic relationships in state psychiatric hospitals.

OBJECTIVE(S) This qualitative study aimed to elucidate barriers and facilitators faced by individuals with serious mental illness in establishing positive therapeutic relationships within the public sector. METHOD Twenty-two individuals, receiving inpatient treatment and near discharge from three state psychiatric facilities, participated. The sample was diverse with respect to gender (60 % male) and race/ethnicity, with a mean age of 40 years (standard deviation = 12.91). Thematic analysis and a contextualist lens were used to analyze the data. RESULTS Results indicated that inadequate meeting time, lack of clinically relevant communication, and discrepancies in client/provider perspectives, impeded positive therapeutic relationships. Facilitators to therapeutic relationships included feelings heard and understood by providers, comprehensive, timely discharge plans, and thinking broadly about aftercare. CONCLUSIONS Cultivating positive therapeutic relationships is especially difficult in resource-challenged settings. Enhanced client-provider communication and individually tailored aftercare planning can enhance inpatient therapeutic relationships, convey a greater sense of understanding of clients, and facilitate client-provider collaboration.
A fast and memory efficient MLCS algorithm by character merging for DNA sequences alignment

MOTIVATION Multiple Longest Common Subsequence (MLCS) problem is searching all longest common subsequences of multiple character sequences. It appears in many fields such as data mining, DNA alignment, bioinformatics, text editing and so on. With the increasing of sequence length and number of sequences, the existing dynamic programming algorithms and the dominant point based algorithms become ineffective and inefficient, especially for large-scale MLCS problems. RESULTS In this paper, by considering the characteristics of DNA sequences with many consecutively repeated characters, we first design a character merging scheme which merges the consecutively repeated characters in the sequences. As a result, it shortens the length of sequences considered and saves the space of storing all sequences. To further reduce the space and time costs, we construct a Weighted Directed Acyclic Graph (WDAG) which is much smaller than widely used DAG for MLCS problems. Based on these techniques, we propose a fast and memory efficient algorithm for MLCS problems. Finally, the experiments are conducted and the proposed algorithm is compared with several state-of-the art algorithms. The experimental results show that the proposed algorithm performs better than the compared state-of-the art algorithms in both time and space costs.
ADHD Is Associated With a Widespread Pattern of Risky Behavior Across Activity Domains

Objective: ADHD has been linked to higher engagement in risky behaviors in circumscribed domains such as dangerous driving, substance abuse, and gambling. This study tests whether ADHD is associated with a pervasive tendency to engage in risky behavior across a spectrum of activities and domains, and whether this tendency is driven by comorbid disorders. Method: A sample of 97 adults with ADHD and 103 typically developing controls completed a self-report questionnaire measuring the likelihood and frequency of engaging in a broad range of risky behaviors. ADHD, comorbid psychiatric disorders, and demographic variables were extensively assessed using standardized instruments. Results: Participants with ADHD reported a pervasive tendency to engage in risky behaviors across multiple activities. This tendency was associated with ADHD over and above the contribution of comorbid psychiatric disorders. Conclusion: These results suggest that ADHD is uniquely linked to a pervasive pattern of engagement in risky behaviors.
Effect of aging on the association between ankle muscle strength and the control of bipedal stance

Previous studies reported a significant association between postural control and lower-limb strength of several muscle groups, however, they were focused especially on knee muscles and ankle plantar and dorsal flexors. The aim of the present study is to examine the correlation between the muscle strength of ankle invertors, evertors, plantar flexors, and dorsal flexors and the control of bipedal stance in young and older adults. Thirty one young (aged 22.8 ± 2.6 years) and thirty one older adults (aged 70.5 ± 7.2 years) voluntarily participated in this study. Ankle muscle strength was evaluated by an isokinetic dynamometer. Normalized peak torque and work were averaged for four repetitions and for both lower limbs. The control of bipedal stance was evaluated by the sample entropy derived from an accelerometer placed on the lumbar spine while the subject stood on a foam pad with eyes open. Results showed significant age-related differences in ankle muscle strength and sample entropy in medial-lateral direction. More interestingly, the correlation between ankle muscle strength and the sample entropy was significantly different between young and older adults. Indeed, no significant correlation was observed in the younger adults. Conversely, in the older adults, the work of the ankle evertors positively correlated with sample entropy in the medial-lateral direction during bipedal stance (r = 0.36), whereas the peak torque and work of the dorsal flexors were significantly correlated with sample entropy in the anterior-posterior direction during bipedal stance (r = 0.44 for both variables). In the young adults, results suggest that, standing on foam with eyes open is a relatively easy postural task that does not require the full ankle muscle strength capacity. Taken together, the present findings suggest that older adults have a different association between ankle muscle strength and the sample entropy during bipedal stance.
Inflammatory serum markers and risk and severity of prostate cancer: The PROCA‐life study

Whether chronic inflammation mirrored by high levels of systemic inflammatory markers such as high sensitive‐CRP (hs‐CRP) and white blood cell count (WBC) are associated with prostate cancer development remains unclear. In the Prostate Cancer Study throughout Life (PROCA‐life), a prospective population‐based cohort study, 7,356 men were included. Prediagnostic WBC and hs‐CRP were assessed from blood collected at study entry; 2,210 participants also had a second CRP measure during follow‐up. During a mean 11.8 years follow‐up, 509 men developed prostate cancer (mean age at diagnosis 71.7 years). Multivariable Cox proportional hazard regression models were used to study whether individual biomarkers (WBC, hs‐CRP), a combined score based on analyte tertiles (score range 2–6), or change in CRP were associated with risk and severity of prostate cancer. We observed a positive dose–response relationship between hs‐CRP and prostate cancer risk with a Hazard Ratio (HR) per mg/l of 1.3, 95% CI 1.00–1.07. Men with an increase in hs‐CRP between two measurements (Δhs‐CRP) of ≥1.00 mg/l had a 36% increased risk of prostate cancer (HR 1.36, 95% CI 1.02–1.82), compared to men with no change or decrease in hs‐CRP. Men with a systemic inflammatory score of 5 or 6 had a 68% higher risk of being diagnosed with metastatic disease (HR 1.68, 95% CI, 1.04–2.73) compared to men with lower scores. Our study supports that hs‐CRP including repeated measurements alone or in combination with WBC may be a useful inflammation‐related biomarker for prostate cancer risk and prognosis.
Improving Organizational Performance Through the Use of Big Data

ABSTRACT The number of firms that plan to invest in big data usage has been reduced as many of them are still trying to understand the necessary conditions needed to improve their performance through the processing and use of big data. In this study, we leverage the resource-based view to investigate the role of tools sophistication, big data utilization, and employee analytical skills in improving organizational performance. The research model is validated empirically from 140 senior IT professionals using survey data. The findings show that when firms process big data, organizational performance is at its highest when firms use sophisticated tools, while this is not the case when firms do not process big data. Furthermore, findings show that, interestingly, at the lower levels of employee analytical skills, there is no significant impact of big data utilization on organizational performance, suggesting important implications for theory and for the guidance of business action.