Miracle-dz/UniFAR-FTUs huggingface dataset:
Biomarkers for the detection of graft-versus-host disease in cancer patients after bone marrow transplantation

Correspondence: Sophie Paczesny University of Michigan Comprehensive Cancer Center 6303,1500 E Medical Center Dr, Ann Arbor, MI 48109-5942, USA Tel +1 734 615 5283 Fax +1 734 647 9271 Email sophiep@med.umich. edu Abstract: Allogeneic hematopoietic stem cell transplantation (HSCT) is the most effective form of tumor immunotherapy available to date, and the frequency of transplants continues to increase worldwide. However, while allogeneic HSCT can induce beneficial graft-versustumor (GVT) effects, the adverse effect of graft-versus-host disease (GVHD), which is closely linked to GVT, is the major source of morbidity and mortality following HSCT. Acute GVHD (aGVHD) develops when the donor’s immune cells from the graft attack the patient’s skin, liver, or intestines. Target organs involved in chronic GVHD (cGVHD) are variable, resemble autoimmune manifestations, and typically include skin; mucosa (mouth, eyes, genitalia); muscles/ fascia/joints; lungs; and gastrointestinal tract/liver. GVHD occurs in two forms, classically distinguished as aGVHD, beginning before day 100 after HSCT, and cGVHD, occurring after day 100, although it is now accepted that these are two separate pathophysiologic entities. Currently available diagnostic and staging tools frequently fail to identify those at higher risk of GVHD progression, unresponsiveness to different forms of therapy, or death. Furthermore, there are shortcomings in the prediction of the future occurrence of GVHD before clinical signs develop. In parallel, in recent years there has been an explosive evolution of proteomics technologies, largely due to important advances in chemistry, engineering, high-throughput technical devices, and bioinformatics. Building on these opportunities, plasma biomarkers have been identified and validated both as promising diagnostic tools of GVHD and as prognostic tools for nonrelapse mortality. These biomarkers might facilitate timely and selective therapeutic intervention. However, such biomarkers should be more widely validated and incorporated into a new grading system to risk-stratify patients and better customize treatment. This review identifies biomarkers for the detection of GVHD; summarizes the current information on available GVHD biomarkers, which are mostly aGVHD biomarkers; proposes future prospects for the blinded evaluation of these biomarkers in samples collected as part of a multicenter prospective study; and discusses the need for biomarkers of cGVHD.
Development and Validation of The Sexual Excitation / Sexual Inhibition Inventory for Women

This article reports on the development of a new questionnaire designed to assess the propensity for sexual excitation and sexual inhibition in women: The Sexual Excitation/Sexual Inhibition Inventory for Women (SESII-W). The theoretical model underlying this research, the Dual Control Model, postulates that sexual response depends on a balance between excitatory and inhibitory mechanisms and that individuals vary in their propensity for excitation and inhibition. This study describes the development and initial validation of the SESII-W in a sample of 655 women (M age, 33.9 yrs). Factor analysis identified eight factors and two higher-order factors, one related to sexual excitation and one to sexual inhibition. The measure demonstrated good test-retest reliability and discriminant and convergent validity. Our data underscore that a number of factors affect women‟s sexual arousal and these appear to be related to opposing processes of sexual excitation and sexual inhibition. Theoretical issues, possible gender differences, and the value of using qualitative data to inform questionnaire development are discussed.
, a new manganese-bearing sulfosalt from the Uchucchacua polymetallic deposit , Lima Department , Peru : Description and crystal structure

Manganoquadratite, ideally AgMnAsS3, is a new mineral from the Uchucchacua polymetallic deposit, Oyon district, Catajambo, Lima Department, Peru. It occurs as dark gray, anhedral to subhedral grains up 0.5 mm across, closely associated with alabandite, Mn-rich calcite, Mn-rich sphalerite, proustite, pyrite, pyrrhotite, tennantite, argentotennantite, stannite, and other unnamed minerals of the system Pb-Ag-Sb-Mn-As-S. Manganoquadratite is opaque with a metallic luster and possesses a reddish-brown streak. It is brittle, the Vickers microhardness (VHN10) is 81 kg/mm2 (range 75–96) (corresponding Mohs hardness of 2–21⁄2). The calculated density is 4.680 g/cm3 (on the basis of the empirical formula). In plane-polarized reflected light, manganoquadratite is moderately bireflectant and very weakly pleochroic from dark gray to a blue gray. Internal reflections are absent. Between crossed polars, the mineral is anisotropic, without characteristic rotation tints. Reflectance percentages (Rmin and Rmax) for the four standard COM wavelengths are 29.5, 31.8 (471.1 nm), 28.1, 30.5 (548.3 nm), 27.3, 29.3 (586.6 nm), and 26.0, 28.2 (652.3 nm), respectively. Manganoquadratite is tetragonal, space group P4322, with unit-cell parameters: a = 5.4496(5), c = 32.949(1) Å, V = 978.5(1) Å3, c:a = 6.046, Z = 8. The structure, refined to R1 = 0.0863 for 907 reflections with Fo > 4σ(Fo), consists of a stacking along [001] of alabandite-like Mn2S2 layers connected to each to other by a couple of AgAsS2 sheets where As3+ forms typical AsS3 groups, whereas Ag+ cations are fivefold coordinated. The six strongest lines in the observed X-ray powder-diffraction pattern [d in Å (I/I0) (hkl)] are: 3.14 (60) (116), 2.739 (50) (0 0 12), 2.710 (100) (200), 1.927(70) (2 0 12 + 220), 1.645 (25) (3 0 16), and 1.573 (20) (2 2 12). Electron microprobe analyses gave the chemical formula (on the basis of six atoms) (Ag0.95Cu0.05)Σ=1.00 (Mn0.96Pb0.04)Σ=1.00(As0.87Sb0.14)Σ=1.01S2. 99, leading to the simplified formula AgMnAsS3. The name was chosen to indicate the close analogy of the formula and unit-cell dimensions with quadratite, Ag(Cd,Pb)(As,Sb)S3. The new mineral and mineral name have been approved by the Commission on New Minerals, Nomenclature and Classification, IMA 2011-008.
Excess Turnover and Employment Growth: Firm and Match Heterogeneity

Portuguese firms engage in intense reallocation, most employers simultaneously hire and separate from workers, resulting in a large heterogeneity of flows and excess turnover. Large and older firms have lower flows, but high excess turnover rates. In small firms, hires and separations move symmetrically during expansion and contraction periods, on the contrary, large firms adjust their employment levels by reducing entry and not by increasing separations. Most hires and separations are on fixed-term contracts and shrinking firms replace a larger share of their separations under fixed-term contracts, while expanding firms replace most of the separations under open-ended contracts. The comparison with the U.S. shows that while worker and job flows are lower in Portugal, the excess turnover is remarkably close in the two countries.
Anticellulite efficacy of Trichilia catigua and Ptychopetalum olacoides Bentham extracts: Eficácia anticelulite de extratos de Trichilia catigua e Ptychopetalum olacoides Bentham

Among all forms of treatment for cellulite, the most commonly used and easy to access are the cosmetic products containing active substances which are vessel-protective, anti-inflammatory, peripheral microcirculation stimulants and lipolytic agents. In this work, the clinical anticellulite efficacy of a commercial extract of Trichilia catigua (Catuaba) and Ptychopetalum olacoides Bentham (Marapuama) was evaluated. Twenty-seven woman subjects between the ages of 20 and 40 years old with moderate gynoid lipodystrophy participated in this study. The Trichilia catigua and Ptychopetalum olacoides Bentham extract was incorporated into a cosmetic emulsion, and the subjects applied this formulation once a day for 60 days. The following parameters were assessed: hypodermic layer thickness by B-mode ultrasonography, cutaneous temperature, and anthropometric measurements. The test product caused an increase in skin temperature after 60 days application without affecting the hypodermic layer thickness. In addition, a statistically significant reduction in circumference of specific body areas was observed (stomach, waist, upper thigh, upper leg, and upper hip). Thus, the results indicated that the Trichilia catigua and Ptychopetalum olacoides Bentham extract was effective in the reduction of the gynoid lipodystrophy aspect, likely by reducing edema and improving local microcirculation.
EMSP Project Number 65015 Final Report: Three-dimensional position-sensitive germanium detectors

FINAL REPORT U.S. Department of Energy Three-Dimensional Position-Sensitive Germanium Detectors Principal Investigator: Mark Amman Principal Investigator Contact Information: Address: Ernest Orlando Lawrence Berkeley National Laboratory 1 Cyclotron Road, MS 70A-3363 Berkeley, CA 94720 Phone: Fax: E-mail: Mark_Amman@lbl.gov Co-Principal Investigator: Paul Luke Co-Principal Investigator Contact Information: Address: Ernest Orlando Lawrence Berkeley National Laboratory 1 Cyclotron Road, MS 70A-3363 Berkeley, CA 94720 Phone: Fax: E-mail: PNLuke@lbl.gov Project Number: 65015 Grant Number: Not applicable (Department of Energy Contract Number DE-AC03-76SF00098) Grant Project Officers: Not applicable (Department of Energy Contacts: Paul Ko, Oakland Office; Robert Price, Headquarters, SC; and Chester E. Miller, Headquarters, EM) Project Duration: September 15, 1998 through September 30, 2001
Impacts of Monetary Policies on Housing Affordability in Australia

Housing affordability has become a major policy issue in many countries across the world since the rapid inflation of house prices. This paper empirically investigates how monetary policies affect housing affordability in Australia from 1998 to 2009. Three primary variables associated with the housing sector and monetary policy, which are money supply, interest rates and house prices, are studied for all eight capital cities in Australia in this research. Shocks of such variables are identified by a structural vector autoregression (SVAR) model with restrictions that are consistent with economic theoretical framework. Based upon the analysis using the structural decomposition of impulse response on quarterly data, it can be discovered that the monetary policy plays an active role in housing affordability via adjustments of money supply and interest rates during the observed period in Australia. The empirical results from this research may be used for decision makers to determine money supply and interest rates from the perspective of housing affordability.
A CONCEPTUAL FRAMEWORK FOR LINE MANAGERS' HRM IMPLEMENTATION EFFECTIVENESS: INTEGRATING SOCIAL CONTEXT AND AMO THEORIES DOI: 10.17261/Pressacademia.2015211620

Over recent decades, there has been an important stream of research that has examined the human resources management (HRM) and organizational effectiveness relationship. However, few of these studies have paid attention to developing perspectives regarding effective HRM implementation. Such implementation is a process that is not only executed by HR managers, for it is also the responsibility of line managers and other employees of the organization. Increasingly, the responsibilities of HRM are being passed on to line managers, who have thus become more involved in dealing with their employees’ HRM issues. This study is aimed at investigating the factors that can influence the degree to which effective HR practices are implemented, going further than previous theoretical studies by proposing a conceptual model of HR implementation effectiveness. We incorporate the social context theory and AMO theory into the model. Social context factors of organizational culture, organizational climate, and political considerations as features of the work environment and top management’s HR support as a higher-order social context dimension are proposed as drivers for effective implementation of HR systems and practices. The model also considers abilitymotivation-opportunity factors as one set of variables that mediates the relationship between social context variables and line managers’ HR implementation effectiveness. This study tries to step into an area of study which has not been comprehensively explored by the scholars. It involves putting forward a model of HR implementation effectiveness by considering the role of line managers and a set of propositions for testing in field. The propositions developed in the model provide guidelines for further study in the focal HRM topic that we believe will generate beneficial findings for both practitioners and academics. Year: 2015 Volume: 4 Issue: 2
A Bitmap Approach for Closed and Maximal Frequent Itemset Mining

Association Rule Mining (ARM) plays a fundamental role in many data mining tasks that attempt to find interesting patterns from databases, such as correlations, sequences, episodes, classifiers, clusters, etc. Frequent Itemset Mining (FIM) is one of the essential parts of ARM which is an active research area and a large number of algorithms have been developed. FIM algorithms may be depth-first or breadth-first approach. Most depth-first based approaches do not effectively address the cost of database projections. Consequently, their performance gets degraded severely as the total number of frequent itemsets in a database increases significantly. To solve this problem, a three - strategy adaptive algorithm, Bitmap Itemset Support Counting (BISC) with the closed and maximal frequent itemset is presented in this paper. The core strategy of the proposed algorithm is the usage of the closed and maximal frequent itemset detection which could be able to find least number of association rules. The proposed approach is compared with the conventional approach to evaluate the performance and accuracy. The experimental results show that the proposed approach outperforms the existing approach. Keywords: Data Mining Algorithms; Bitmap; Frequent Itemset Mining; Association Rule Mining.
Fractal Techniques for Human Face Recognized Mail Accessor with Pattern Based Spam Filtering

High effective authentication with the purpose of log on to the email service securely and efficient spamming are taken into Consideration. Normal authentication for logging into the email service by means of username and password characters are applicable in the existing system. But it is not secure because if anyone knows the password means they can access the mail. In proposed system, authentication in the form of fractal detection and recognition after contour detection of the face using the image of the user is introduced. Since fractal detection and recognition is an unique method to identify every human being, this concept is more effective in terms of authenticating into the service. Spam mail id and keyword filtering are the methods used in the existing system. Domain and url based spam filtering are the filtering techniques used in the proposed system.
The Effects of a Pedagogical Agent's Smiling Expression on the Learner's Emotions and Motivation in a Virtual Learning Environment.

The present study aimed to test the hypothesis that a smiling expression on the face of a talking pedagogical agent could positively affect a learner’s emotions, motivation, and learning outcomes in a virtual learning environment. Contrary to the hypothesis, results from Experiment 1 demonstrated that the pedagogical agent’s smile induced negative emotional and motivational responses in learners. Experiment 2 showed that the social meaning of a pedagogical agent’s smile might be perceived by learners as polite or fake. In addition, qualitative data provided insights into factors that may cause negative perceptions of a pedagogical agent’s smile, which in turn lead to negative affective (emotional and motivational) states in learners. Theoretical and design implications for pedagogical agents in virtual learning environment are discussed in the concluding section of the paper.
PALYNOFACIES AND THERMAL MATURATION ANALYSIS OF SEDIMENTS FROM THE NANKAI TROUGH 1

Analysis of the palynofacies and miospore thermal alteration indices (TAI) of sediments from ODP Site 808 in the Nankai Trough was undertaken to determine (1) the source, depositional environment, and diagenesis of organic matter in the accreted sediments, and (2) the thermal structure and history of the prism and its relationship to fluid flow. Using the Hartax classification system, two palynofacies were recognized in the sedimentary sequence. Facies 1 occurs within the upper 600 m of trench-wedge turbidites (sedimentation rate > 1 km/m.y.) and contains >50% inertite particles. The rest of the assemblage is dominated by well-preserved phytoclasts and contains small amounts of poorly preserved phytoclasts and well-preserved scleratoclasts. Facies 2 occurs within the Shikoku Basin hemipelagites (600-1300 m below seafloor; sedimentation rate <150 m/m.y.) and contains over two-thirds inertite particles. The rest of the assemblage is dominated by poorly preserved phytoclasts. Miospores and marine phytoplankton compose only a small percentage of both palynofacies. Degraded organic matter is most noticeable in Facies 2, whereas its presence in Facies 1 is overshadowed by the high influx of well-preserved primary organic matter. Most of the degraded organic matter and inertite is interpreted to be reworked. Some of the degraded organic matter may be primary, and may have experienced more biodegradation and thermal alteration in Facies 2 than in Facies 1. TAI values indicate an immature stage of organic maturation (< 2) down to about 900 mbsf. Below this, samples show an increase with depth to a mature stage, reaching peak levels of about 3~ just above basement. Samples from within the thrust fault and décollement zones do not show levels of maturity significantly greater than those of surrounding samples, leaving uncertain whether hot fluids have migrated along these fault boundaries in the past.
Evaluation of Antimicrobial Activity of Probiotic Lactobacillus Strains against Growth and Urease Activity of Proteus spp.

Background : Nowadays, the use of probiotic bacteria for the prevention and treatment of urinary tract infections is growing. Lactobacillus , as probiotic bacterial genus, is well known for its benefits for the human health. Methods : The effects of partially purified antimicrobial compounds (bacteriocins and biosurfactants) of Lactobacillus strains was assessed and their capacity to in vitro inhibit growth and urease production of various strains of Proteus spp, was studied. Inhibition of the urease production of Proteus spp. at sub-MIC levels was screened using spectrophotometry method. Results : Results revealed that semi-purified bacteriocins of L. acidophilus and L. plantarum showed a greater inhibitory activity on the bacterial urease, compared to biosurfactants of L. rhamnosus , L . casei and L. fermentum (P < 0.05). Conclusion : It can be concluded that bacteriocins may affect Proteus pathogenesis by inhibition of the bacterial urease activity and therefore eliminate the stone formation by these bacteria.
Truck Loading Dock Process – Investigating Integration of Sustainability

Truck loading docks as a bottleneck and a logistics interface notoriously plagued with misunderstandings and scheduling issues recently came to the attention of research in the wake of the 2011 report of the German federal office for goods transport. At the truck loading dock the different objectives of road haulers and warehouse operators collide having implications for the whole supply chain. This study aims to verify problems identified in earlier studies with a special focus on SME and explore the question how practitioners would include sustainability measures in that process. A qualitative interview method was used for the investigation, including various players from the logistics industry. A focus group discussion as well as nine face-to-face semi-structured interviews were used to gather optimization and sustainability integration suggestions for the loading dock processes. An increased need for information, a primary focus on efficiency as a method to become more sustainable, especially ecological sustainability as well as a lack of consideration of social issues were found. The research is limited due to the small sample that naturally cannot take all perspectives into account. The perspective of truck drivers is not included. Practitioners are to gather new ideas for the sustainability concepts as well as optimization methods for the loading dock processes in their enterprises; a long term outcome of this research project will be a best-practice catalogue.
Investigation of Heat and Airflow Characteristics in Partitioned Zone with Mixed Ventilation for Building Applications

The heat and airflow characteristics inside a room were investigated numerically and experimentally for their potential building applications. Constant heat sources at different intensities and locations were considered over a range of Reynolds numbers 10 2 ≤ Re ≤10 4 and a Grashof number of Gr = 10 6 considering mixed ventilation. The main model considered a single heat source in the middle of the room with an air supply inflow located in the ceiling. The two-dimensional governing equations were solved numerically using the finite volume technique under steady state conditions. An experimental set-up was designed and constructed to study the validity of the main model. A reasonable agreement was found between the theoretical and experimental results. To support this conclusion, two applications testing four different case studies were considered by using two different workstation scenarios and different heat source locations. The optimal transitional region ranging between predominately natural convection to forced convection was investigated. The parameter Gr/Re 2 was introduced as a measure of the strength of the mixed convection. The results showed the isotherm and streamline contours inside the ventilated zone were affected by the value of the Reynolds number. The first experimental application determined the maximum surface temperature of the highest heat source intensity occurs at its far side from the air supply. The Reynolds number test values were found to be independent of the workstation scenario conditions tested, especially at Re > 10 3 . During testing of the second application, the maximum computer surface temperature was decreased with an increase in the Reynolds number.