Miracle-dz/UniFAR-FTUs huggingface dataset:
BOREHOLE DATA AND SITE AMPLIFICATIONS IN THE TAIPEI METROPOLITAN AREA

There are 18 boreholes inside the Taipei Metropolitan Area (TMA), which is on and around the Taipei Basin. Among them, 7 boreholes are located outside but near the TMA. The core samples of the 18 sites show that geological materials below them belong to the Sungshan formation, which is a soft layer and composes of unconsolidated sand, silt and clay. The depths of the 18 boreholes range from 30 to 56 m. The majority of the boreholes have a depth of 30 m. The depths of 2 boreholes at a Class-C site and a Class-E one are greater than 40 m. The shear velocities and densities were measured at each borehole. The shear velocity was measured every 0.5 m. The total number of samples of shear-velocity loggings is 1126 and the measured values are in the range 93–1235 m/s. Except for few sites, the velocity range is smaller inside than outside the basin. Inside the basin, except for sites 09 and 22, the maximum velocity is less than 500 m/s. The maximum velocity is larger to the east than to the west of the basin. Among the 18 sites, there is a Class-B site, 6 Class-C sites, 10 Class-D sites, and a Class-E site. The Class-B and C stations sites are located at the mountains outside the Taipei Basin, while the Class-C and D ones inside the basin. The density was measured only at one point in a certain geological layer. The total number of logging samples of densities is 308 and the measured values are in the range 1.3–2.3 gm/cc. At some welllogging points, where the shear-velocity was measured, yet lack of density, the density measured at a nearby one, which belongs to the same geological layer as the former, is assigned. A complete well-logging profile including the two parameters can, thus, be constructed at each borehole site. Based on the well-logged data, the frequent-dependent site amplifications, A[f(z)], are evaluated. Results show that at a unique Class-B site, A[f(z)] first decreases and then increases with increasing frequency, and the value varies from 15 to 1.6. At the Class-E site, A[f(z)] first increases and then decreases with increasing frequency, with a peak almost at f=5 Hz. At the Class-C and D sites, except for the data point with f>100 Hz, the amplification–frequency functions first increase with frequency, and then become flat when f>10 Hz.
A Seed Expansion Graph Clustering Method for Protein Complexes Detection in Protein Interaction Networks

Most proteins perform their biological functions while interacting as complexes. The detection of protein complexes is an important task not only for understanding the relationship between functions and structures of biological network, but also for predicting the function of unknown proteins. We present a new nodal metric by integrating its local topological information. The metric reflects its representability in a larger local neighborhood to a cluster of a protein interaction (PPI) network. Based on the metric, we propose a seed-expansion graph clustering algorithm (SEGC) for protein complexes detection in PPI networks. A roulette wheel strategy is used in the selection of the seed to enhance the diversity of clustering. For a candidate node u, we define its closeness to a cluster C, denoted as NC(u, C), by combing the density of a cluster C and the connection between a node u and C. In SEGC, a cluster which initially consists of only a seed node, is extended by adding nodes recursively from its neighbors according to the closeness, until all neighbors fail the process of expansion. We compare the F-measure and accuracy of the proposed SEGC algorithm with other algorithms on Saccharomyces cerevisiae protein interaction networks. The experimental results show that SEGC outperforms other algorithms under full coverage.
Cdk5‐Dependent Activation of Neuronal Inflammasomes in Parkinson's Disease

Inflammasomes, which mediate the activation of caspase‐1 and maturation of IL‐1β and IL‐18, have been unambiguously verified to participate in many diseases, such as lung diseases, infectious diseases and Alzheimer's disease, but the relation between Parkinson's disease and inflammasomes is poorly understood.
Branch correlation measurements in an indoor raleigh fading channel for polarization diversity using a dual polarized patch antenna

Spatial diversity techniques like polarization diversity, Space-Time Coding or Maximum Ratio Combining are advantageous if the received signals of the diversity branches are sufticiently uncorrelated. lndoor non-lineof-sight measurements were carried nut to study the cross-correlation between two received signals of orthogonal polarization using a dual linear polarized patch antenna. The antenna has been designed, built and measured at IRCTR. This paper gives the results of the channel measurements. It is concluded that received signals with orthogonal polarization in indoor Rayleigh fading channels have no significant envelope correlation.
Efficacy and safety of enoxaparin to prevent deep venous thrombosis after hip replacement surgery. Enoxaparin Clinical Trial Group.

OBJECTIVE To determine the most effective and safe dose of enoxaparin to prevent deep venous thrombosis in high-risk surgical patients. DESIGN A double-blind, randomized, multicenter clinical trial. SETTING Private, university, and government hospitals in the United States. PATIENTS 572 patients having elective hip replacement surgery, 568 of whom received study medication and had efficacy data available for evaluation. INTERVENTIONS Patients were randomly assigned to one of three subcutaneous enoxaparin regimens: 10 mg once daily (161 patients); 40 mg once daily (199 patients); and 30 mg every 12 hours (208 patients). Treatment was initiated within 24 hours after surgery and continued for as long as 7 days. Treatment with 10 mg enoxaparin once daily was discontinued prematurely after an interim analysis showed an increased deep venous thrombosis incidence in this treatment group. MEASUREMENTS Efficacy was determined by bilateral lower extremity venography, noninvasive vascular imaging methods, or clinical evidence on day 7 of treatment or earlier if clinically indicated. RESULTS Deep venous thrombosis occurred in 25% (40 of 161) of the patients who received 10 mg of enoxaparin once daily; in 14% (27 of 199) of those receiving 40 mg of enoxaparin once daily; and in 11% (22 of 208) in those receiving 30 mg of enoxaparin every 12 hours. The incidence of deep venous thrombosis was significantly higher in patients who received 10 mg of enoxaparin once daily compared with those who received 40 mg of enoxaparin once daily (P = 0.02) or those who received 30 mg of enoxaparin every 12 hours (P < 0.001). The difference between the patients who received 40 mg once daily and those who received 30 mg every 12 hours was not significant. Only two cases of pulmonary embolism were diagnosed, one in patients receiving 40 mg of enoxaparin and one in those receiving 10 mg once daily. The incidence of hemorrhagic complications differed significantly between patients who received 10 mg of enoxaparin once daily (5%, 8 of 161 patients) and those who received 30 mg of enoxaparin every 12 hours (13%, 26 of 208; P < 0.05). CONCLUSIONS After surgery, enoxaparin, 40 mg once daily or 30 mg every 12 hours, is more effective than a regimen of 10 mg once daily to prevent deep venous thrombosis in patients having elective hip replacement surgery. The regimens of 40 mg once daily and 30 mg every 12 hours provided prophylaxis similar to the most effective drug treatments previously reported. The incidence of hemorrhagic episodes with the regimens of 40 mg once daily and 30 mg twice daily was higher than that observed with 10 mg once daily; however, major hemorrhage occurred in only 4% to 5% of patients receiving the higher-dose regimens. The risk-to-benefit ratio supports the use of enoxaparin as a therapeutic agent to prevent deep venous thrombosis in these patients.
Development of a Universal Connectivity and Data Management System

Point-of-care testing (POCT) is an increasingly popular method of delivering laboratory testing. Management of POCT is challenging given the variety of devices, locations, and staff that need to be coordinated to ensure quality results and meet regulatory guidelines. Electronic capture and transfer of data are preferred for managing POCT, but there is currently no standard method of connecting different devices. Johns Hopkins Medical Institutions (JHMI) developed a common data management system with interfaces to all of its POCT devices. All POCT data are collected in one database and analyzed in a similar fashion. Where data were once collected by carrying laptops to each nursing unit, the POCT devices can now connect directly to the database over the Internet. Algorithms have been created to automate the data analysis and review process. Over the several years that this software has been used, JHMI has experienced improved quality, accuracy, and management of its POCT program. The labor saved by increased automation of data review is refocused on enhancing the performance and scope of the program. Current connectivity and analysis algorithms have future application to remote consultation, management of home self-monitoring patients, and examination of real-time data.
A further account of the idiots savants, experts with the calendar.

The authors present a further account of twins, classifiable as idiots savants, whose ability to name the day of the week for a given date in any year, and the converse, has led to conjecture on the mechanism by which they perform the feat. Their method is explained as the ability to subtract multiples of a 400-year calendar cycle from any given year.
Calibration of immunohistochemistry for assessment of HER2 in breast cancer: results of the French Multicentre GEFPICS * Study

Aims: HER2 protein is over‐expressed in 15–30% of breast carcinomas. Immunohistochemistry (IHC) is a common and inexpensive method able to specifically detect HER2 protein. However, lack of standardization of IHC has been considered responsible for discrepancies in HER2 status assessment performed by IHC and fluorescence in‐situ hybridization (FISH). This prompted us to perform a multicentric IHC calibration test to achieve a maximum accuracy of HER2‐IHC compared with HER2‐FISH taken as the reference method.
Recurrent trauma in elderly patients.

HYPOTHESIS Older patients (those aged > or = 70 years) who have experienced trauma have an increased risk of recurrent trauma. Demographic, medical, and functional factors are potential contributors to the risk of subsequent trauma among injured elderly patients. DESIGN Retrospective follow-up study. PARTICIPANTS Study participants were derived from the Longitudinal Study of Aging, an extension of the 1984 National Health Interview Survey focusing on persons who were aged 70 years and older in 1984. A cohort of elderly patients participating in the Longitudinal Study of Aging and hospitalized for injury in 1985 (n = 100) was identified using Medicare hospital discharge data. An uninjured cohort (n = 401) was also identified from the Longitudinal Study of Aging and matched for age (1 year) and sex. MAIN OUTCOME MEASURES Risk of admission for trauma among the injured cohort compared with the uninjured cohort and associations between demographic, medical, and functional characteristics and trauma recurrence. RESULTS Following adjustment for potential confounding factors, the injured cohort was 3.25 times more likely (95% confidence interval, 1.99-5.31) to be hospitalized for injury during the follow-up period compared with the uninjured cohort. Among the injured cohort, those at greatest risk of subsequent trauma included women and those with chronic medical conditions or functional impairments, the latter being the only factor independently associated with recurrence. CONCLUSIONS Elderly patients who have experienced trauma are at increased risk of subsequent injury. Interventions to reduce the likelihood of trauma recurrence should focus on those with chronic illnesses and functional impairments.
Dimethyl 1-(3-hydroxy-2-iodo-1-phenylpropyl)-1H-1,2,3-triazole-4,5-dicarboxylate

In the title compound, C15H16IN3O5, the central triazole ring is essentially planar (r.m.s deviation = 0.0034 Å) and makes a dihedral angle of 70.14 (5)° with the pendant benzene ring. The mean planes of the two methoxycarbonyl groups make dihedral angles of 22.52 (7) and 40.93 (4)° with the triazole ring. In the crystal, inversion dimers linked by pairs of O—H⋯O hydrogen bonds generate R 2 2(18) loops. The dimers are linked by C—H⋯O and C—H⋯N interactions into sheets lying parallel to the ac plane.
Hand force estimation using fast orthogonal search

The use of the fast orthogonal search (FOS) method is presented for the estimation of human hand force based on electromyogram (EMG) signal readings and sensed elbow angular position. The use of inexpensive and easily portable EMG electrodes and position sensors would be advantageous in many applications compared to the use of force sensors which are often very expensive and require bulky frames to be used. A single degree-of-freedom robotic experimental testbed has been constructed which allows for data collection, model identification and validation of EMG-force models. FOS identifies the models extremely rapidly with similar or better accuracy compared to existing methods.
Modified Adenovirus Reduces De Novo Peritoneal Adhesions in Rats and Limits Off-Target Transfection. Role of EZH2 in Adhesion Formation

ABSTRACT Aim of the study: Adenovector encoding tissue plasminogen activator (tPA) was shown to reduce experimental peritoneal adhesion. We investigated the targeting potential of our modified adenovector, its ability to reduce adhesions and the epigenetic role of histone methyltransferase EZH2 in adhesion formation. Materials and methods: Control lacZ, nonmodified tPA or modified tPA vectors were instilled in the peritoneal cavity after injury in de novo adhesions or after lysis of adhesions in recurrent adhesions. Adhesion severity was scored and adhesions and liver tissues were examined for adenovirus E4 gene and tPA mRNA expression. Levels of tPA, plasminogen activator inhibitor-1 (PAI-1), transforming growth factor-β1 (TGF-β1), and EZH2 expression were measured. Results: E4 transcripts were detected in adhesions of nonmodified and modified and in livers of nonmodified but not in livers of modified de novo adhesions. Both nonmodified (p = 0.021) and modified vectors (p = 0.036) reduced the severity of de novo adhesions compared to lacZ vector. Levels of tPA in nonmodified (p = 0.021) and modified adhesions (p = 0.001) were elevated while PAI-1 (p = 0.013 and p = 0.001, respectively) and TGF-β1 levels (p = 0.002 and p = 0.016, respectively) were reduced compared with lacZ group. All vectors were not expressed in recurrent adhesions and severity score were not different among groups. EZH2 levels were elevated in de novo nontreated (p = 0.001) and was further increased in recurrent (p = 0.001) nontreated adhesions compared with noninjured peritoneum. Conclusion: Modified adenovirus successfully targeted de novo adhesions but not liver tissues and reduced the severity of de novo adhesions. EZH2 is involved in the development and progression of peritoneal adhesions.
WWTS (What Would Turing Say?)

Turing’s Imitation Game was a brilliant early proposed test of machine intelligence — one that is still compelling, today, despite the fact that in the hindsight of all that we’ve learned in the intervening 65 years we can see the flaws in his original test. And our field needs a good “Is it AI yet? ” test more than ever, today, with so many of us spending our research time looking under the “shallow processing of big data” lamppost. If Turing were alive today, what sort of test might he propose?
Improving tag recommendation using social networks

In this paper we address the task of recommending additional tags to partially annotated media objects, in our case images. We propose an extendable framework that can recommend tags using a combination of different personalised and collective contexts. We combine information from four contexts: (1) all the photos in the system, (2) a user's own photos, (3) the photos of a user's social contacts, and (4) the photos posted in the groups of which a user is a member. Variants of methods (1) and (2) have been proposed in previous work, but the use of (3) and (4) is novel. For each of the contexts we use the same probabilistic model and Borda Count based aggregation approach to generate recommendations from different contexts into a unified ranking of recommended tags. We evaluate our system using a large set of real-world data from Flickr. We show that by using personalised contexts we can significantly improve tag recommendation compared to using collective knowledge alone. We also analyse our experimental results to explore the capabilities of our system with respect to a user's social behaviour.
An integrated approach to an analysis of symptom management in patients with cancer.

PURPOSE/OBJECTIVES To provide a definition, describe uses, and identify essential attributes of symptom management by emphasizing the philosophical base for the concept. DATA SOURCES 51 references (i.e., books and articles) published from 1980-2003 and located through the Ovid database. DATA SYNTHESIS Symptoms are subjective and personal phenomena, incorporating the dimensions of symptom occurrence, symptom distress, and symptom experience. Symptom management has been conceptualized and described as self-activity. Symptom status is the direct outcome of symptom management, with symptom distress, quality of life, and performance as major indicators. CONCLUSIONS The essential attributes of symptom management in patients with cancer are subjectivity, experientiality, intentionality, multidimensionality, dynamic process, and positive and negative outcomes. IMPLICATIONS FOR NURSING Findings can help oncology nurses and other healthcare professionals to better understand the process of managing a symptom and the influential factors that affect positive outcomes. The information from this analysis can be used to design educational and interventional programs for symptom management. Future research is needed to establish interventions that relieve and decrease the distress from or prevent the occurrence of symptoms.
A three-staged approach to medicine box recognition

This paper proposes a novel take on the task of medicine box recognition using a three-staged approach. We present the algorithms that will be used for each stage: barcode recognition, text recognition and feature matching techniques. The final goal of the system is to use a camera mounted on a device using an Android system to correctly identify medicine boxes and then provide people with difficulties (elderly, visually impaired) with relevant information about it. We report a good success rate of 80% in identifying boxes using their barcodes (in still pictures) or by running an OCR to detect the drug name. The success rate is higher (100%) in the case of feature matching, but the developed method is slow in its present form.
Regional Stability Analysis of Implicit Polynomial Systems

This paper focuses on the regional stability analysis of implicit polynomial systems subject to constant uncertain parameters. A polynomial Lyapunov function is computed that assures the robust local stability of the system and also provides an estimate of the domain of attraction. The stability conditions are cast as a set of linear matrix inequalities. A numerical example illustrates the effectiveness of the proposed method
Staurosporine Induces Programmed Cell Death in Embryonic Neurons and Activation of the Ceramide Pathway

Abstract: We activated the death pathway in embryonic chick cerebral hemisphere neuron (E7CH) cultures with staurosporine (0.1–1.0 µM) and observed the morphological changes, DNA laddering patterns, and DNA fragmentation (determined by Hoechst 33258 dye) associated with apoptosis. N‐Acylsphingosine (C2‐ceramide), a soluble ceramide analogue, was also able to induce apoptosis in these cells with the same characteristics and in the same time frame. We then observed that staurosporine was effective in inducing hydrolysis of sphingomyelin to ceramide as measured by a threefold increase in ceramide mass and increased incorporation of [3H]‐palmitate into ceramide, concurrent with activating the cell death program. Furthermore, the coaddition of a specific ceramidase inhibitor, oleoylethanolamine (15 µM), enhanced the formation of ceramide as well as the degree of DNA fragmentation and cell death. Exogenous addition of sphingomyelinase activated the death pathway whereas ceramide glycanase did not, and inhibitors of sphingomyelin or protein synthesis failed to block this type of killing. Our data suggest that the formation of ceramide from sphingomyelin is a key event in staurosporine‐induced and potentially all programmed cell death.
Discharge patterns of human C-fibers induced by itching and burning stimuli.

1. The aim of this investigation was to study the peripheral neural mechanisms of the C-fiber-mediated modalities of burning pain and itch by the use of microneurography of human unmyelinated afferents. 2. Sixteen stable recordings of single C-fibers and 6 multiunit recordings were obtained from the superficial radial nerves of volunteers. All units were excited by stimulating their receptive fields with von Frey bristles (range 10-600 mN), and all but four units were also driven by radiant heat stimulation. 3. Histamine was iontophoretically applied to the receptive fields of these units for 20 or 30 s and was found to provoke itching sensations lasting several minutes, together with wheal and flare responses. Subsequently a solution containing 20 or 30% mustard oil was applied to the receptive field of the respective unit, which provoked a sensation of burning pain. 4. One-half of the units were excited by histamine, and the median discharge rates derived from interspike intervals ranged from approximately 0.1 to 0.8 Hz. Mustard oil-induced activity was observed in all histamine-sensitive units and also in three single units and in one multiunit recording that revealed no histamine response. Median interval-derived discharge rates ranged from 0.2 to 1.2 Hz. 5. Analysis of the interspike interval distribution and of the autocorrelation function derived from the chemically induced discharges of single units provided no evidence for an encoding of itch and burning pain in different discharge patterns of units responding to histamine and to mustard oil. (ABSTRACT TRUNCATED AT 250 WORDS)