Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of Yellow and Blue Sticky Cards for Detection and Monitoring Parasitoid Wasps of the Invasive Halyomorpha halys (Hemiptera: Pentatomidae)

Abstract The invasive Halyomorpha halys (Stål) is a significant agricultural and urban nuisance pest in many parts of the world. In North America, biological control of H. halys by parasitoid wasps in the families Scelionidae and Eupelmidae has shown promise. An effective technique for detection and monitoring native and exotic parasitoids is the deployment of yellow sticky cards; however, yellow cards also attract nontarget arthropods, reducing efficiency and accuracy of parasitoid screening. This study sought to identify an alternative yet effective trapping technique by comparing the number of target parasitoid wasps [Anastatus spp. Motschulsky (Hymenoptera: Eupelmidae), Telenomus spp. Haliday (Hymenoptera: Scelionidae), and Trissolcus spp. Ashmead (Hymenoptera: Scelionidae)] and arthropod bycatch on yellow and blue sticky cards deployed in urban, orchard, and vegetable landscapes in northern Utah from late May to early October in 2019 and 2020. Yellow sticky cards captured 54–72% more target parasitoids than blue cards from June through August in all three landscape types in both years; however, a positive correlation in parasitoid capture indicated blue cards detect target parasitoids, just in fewer numbers. Both card colors detected adventive Trissolcus japonicus (Ashmead) (Hymenoptera: Scelionidae) in initial findings of 2019, and in expanded locations of 2020. Furthermore, blue cards captured 31–48% less Diptera and nontarget Hymenoptera than yellow cards in both years across all three landscapes, translating to reduced card processing time and impacts to beneficial insect populations. Our results suggest that blue vs yellow sticky cards offer an alternative monitoring technique to survey for H. halys parasitoids.
The cricothyroid versus the spray-as-you-go method for topical anesthesia during flexible bronchoscopy: A systematic review and meta-analysis of randomized controlled trials

Background: Lignocaine can be administered during bronchoscopy using either a direct injection through the cricothyroid membrane (the cricothyroid method) or a spray of lignocaine solution through the bronchoscope working channel (the spray-as-you-go method). In this meta-analysis of randomized controlled trials (RCTs), we compared the efficacy of these two methods for topical anesthesia during flexible bronchoscopy. Methods: We performed a systematic search to extract the relevant RCTs comparing the two techniques. Results: Five RCTs meeting the inclusion criteria (747 subjects) were identified. The cricothyroid method was associated with significantly less cough (standardized mean difference [SMD] = −1.18, 95% confidence interval [CI] [−1.75, −0.62], P < 0.001, significant heterogeneity I2 = 86%, P < 0.001). On analysis of secondary outcomes, the cricothyroid method was associated with a greater operator-rated procedure satisfaction (SMD = 1.00, 95% CI [0.74, 1.25], P < 0.001), less time for upper airway negotiation (mean difference, MD = −0.99, 95% CI [−1.37, −0.6], P < 0.001), and a significantly less cumulative dose of lignocaine administered (MD = −68.12, 95% CI [−130.18, −6.06], P = 0.03). The overall procedure duration (MD = 0.08, 95% CI [−0.09, 0.24], P = 0.36) and patient discomfort (MD = −0.08, 95% CI [−0.38, 0.22], P = 0.59) were not different between the two methods. There was no significant publication bias (P = 0.94). Conclusions: The cricothyroid method is associated with less cough during flexible bronchoscopy. Other advantages are a greater operator-rated procedure satisfaction at a less cumulative lignocaine dose. These findings highlight the superior performance characteristics of the cricothyroid method for lignocaine administration for flexible bronchoscopy.
A scoping review of Clinical Studies, Hospital Group Reports and National Strategic Documents on vascular access devices in cancer patients

Introduction: The extent of vascular/venous access device (VAD) research output from the Island of Ireland is unknown. The identification of the papers available is important to create a future research agenda. Objectives: The main objective of this study is to answer three questions: What is the number and descriptive quality of reported Vascular Access Device literature from the Island of Ireland? Is the reporting of Catheter Related Infection rates for cancer patients common in Irish Hospital Groups, National Cancer Reports and Publication Outputs? What are the implications for future research in this area? Methods: We used a scoping review and searched selected databases, grey literature and hospital regulatory bodies websites following the Joanna Briggs Institute Guidelines 2017. A data charting form was developed based on a template from the Joanna Briggs Institute and this was used to extract data from the included reports. Results: A total of 660 reports were screened. Sixty-one full text articles were reviewed from which 20 reports were included for data extraction. Of the reports included the following designs were used: nine retrospective study designs, four guidelines, two prospective study designs, two literature reviews and one of the following; survey, case study and cross sectional analysis designs. We did not identify any randomised controlled trials, systematic reviews, meta-analysis, meta-synthesis and scoping reviews. Five studies included catheter related infection rates. Gaps in the research include the collection of data sets and the need to establish a VAD registry; develop core outcomes for VADs; assessment and evaluation of VAD care bundles among cancer patients; and, the inclusion of public and patient involvement in future VAD research. Conclusion: The reporting of VAD outcomes in published literature regarding cancer patients receiving treatment in Ireland is inconsistent and varied with no interventional studies addressing vascular access complications in cancer care.
Isolation and characterization of mercury-resistant microbes from gold mine area in Mount Pongkor, Bogor District, Indonesia

Sanjaya WTA, Khoirunnisa NS, Ismiani S, Hazra F, Santosa DA. 2021. Isolation and characterization of mercury-resistant microbes from gold mine area in Mount Pongkor, Bogor District, Indonesia. Biodiversitas 22: 2656-2666. Exploring novel wild-type microbes is very important to give more flexibility for bioremediation implementation. It is related to discovering strain with higher detoxification ability and more reliable degradation mechanisms. Moreover, novel strain can be used as genetic material for strain development by molecular genetic engineering and production design formulation. The aims of this experiment were to characterize and identify new mercury-resistant microbes, investigate their capacity to accumulate mercury, and analyze the reducing mercury toxicity in bioassay. Four strains of bacteria selected through the screening stage were characterized for their morphological, biochemical, physiological, and molecular genetic characteristics. Considering their characteristics and mercury resistance levels, there are two selected microbial strains: fungus strain Cladosporium halotolerans Hg32 and the bacterial strain Mycolicibacterium peregrinum Hg37 with a mercury resistance level up to 3000 mg L. The C. halotolerans Hg32 could remove mercury with the highest potency up to 90.72% at a mercury concentration of 100 mg L, while M. peregrinum Hg37 removes up to 77.10% at mercury concentrations of 10 mg L. Toxicity bioassay tests using fish confirmed that C. halotolerans Hg32 and M. peregrinum Hg37 had the ability to detoxify mercury in contaminated water. Both have successfully proven to reduce the mortality rate to below 5%.
Cardiovascular disease related circulating biomarkers and cancer incidence and mortality: is there an association?

AIMS Recent studies suggest an association between cardiovascular disease (CVD) and cancer incidence/mortality, but the pathophysiological mechanisms underlying these associations are unclear. We aimed to examine biomarkers previously associated with CVD and study their association with incident cancer and cancer-related death in a prospective cohort study. METHODS AND RESULTS We used a proteomic platform to measure 71 cardiovascular biomarkers among 5,032 participants in the Framingham Heart Study who were free of cancer at baseline. We used multivariable-adjusted Cox models to examine the association of circulating protein biomarkers with risk of cancer incidence and mortality. To account for multiple testing, we set a 2-sided false discovery rate (FDR Q-value) <0.05. Growth differentiation factor-15 (GDF15; also known as macrophage inhibitory cytokine-1 [MIC1])) was associated with increased risk of incident cancer (hazards ratio [HR] per 1 standard deviation increment 1.31, 95% CI 1.17-1.47), incident gastrointestinal cancer (HR 1.85, 95% CI 1.37-2.50), incident colorectal cancer (HR 1.94, 95% CI 1.29-2.91) and cancer-related death (HR 2.15, 95% CI 1.72-2.70). Stromal cell-derived factor-1 (SFD1) showed an inverse association with cancer-related death (HR 0.75, 95% CI 0.65-0.86). Fibroblast growth factor-23 (FGF23) showed an association with colorectal cancer (HR 1.55, 95% CI 1.20-2.00), and granulin (GRN) was associated with hematologic cancer (HR 1.61, 95% CI 1.30-1.99). Other circulating biomarkers of inflammation, immune activation, metabolism, and fibrosis showed suggestive associations with future cancer diagnosis. CONCLUSION We observed several significant associations between circulating CVD biomarkers and cancer, supporting the idea that shared biological pathways underlie both diseases. Further investigations of specific mechanisms that lead to both CVD and cancer are warranted. TRANSLATIONAL PERSPECTIVE In our prospective cohort study, baseline levels of biomarkers previously associated with CVD were found to be associated with future development of cancer. In particular, GDF15 was associated with increased risk of cancer incidence and mortality, including gastrointestinal and colorectal cancers; SDF1 was inversely associated with cancer-related death, and FGF23 and GRN were associated with increased risk of colorectal and hematologic cancers, respectively. Other biomarkers of inflammation, immune activation, metabolism, and fibrosis showed suggestive associations. These results suggest potential shared biological pathways that underlie both development of cancer and CVD.
On the Correlation Among Edge, Pose and Parsing

Semantic parsing, edge detection, and pose estimation of human are three closely-related tasks. They present human characteristics from three complementary aspects. Compared to learning them individually, solving these tasks jointly can explore the interaction of their contextual cues. However, prior works usually study the fusion of two of them, e.g., parsing and pose, parsing and edge. In this paper, we explore how pixel-level semantics, human boundaries and joint locations can be effectively learned in a unified model. Specifically, we propose an end-to-end trainable Human Task Correlation Machine (HTCorrM) to implement the three tasks. It is asymmetric in that it supports a main task using the other two as auxiliary tasks. We also introduce a Heterogeneous Non-Local module (HNL) to discover the correlations of the three heterogeneous domains. HNL fully explores the global dependency among tasks between any two positions in the feature map. Experimental results on human parsing, pose estimation and body edge detection demonstrate that HTCorrM achieves competitive performance. We show that when designated as the main task, the accuracy of each of the three tasks is improved. Importantly, comparative studies confirm the advantages of our proposed feature correlation strategy over feature concatenation or post processing.
Power quality metrics for DC grids with pulsed power loads

DC grids can effectively feed pulsed power loads (PPLs), integrating local energy storage to minimize the impact on other connected loads and implementing buffered sub-grids to isolate susceptible loads even more. The identification of regulatory limits for PPL integration and DC grid response and the assessment of PPL impact necessitate suitable Power Quality (PQ) metrics. Existing indexes and limits (e.g. ripple and distortion, voltage fluctuation) are compared to other metrics, derived from control methods and knowledge of the peculiar characteristics of PPL and interaction with DC grids in some examples. The objective is a unified approach for PQ metrics suitable for a wide range of DC grids and in particular to the behavior of PPLs.
Hematological cancers in individuals infected by HIV.

HIV infection increases cancer risk and is linked to cancers associated to infectious agents classified as carcinogenic to humans by the International Agency for Research on Cancer. Lymphomas represent one of the most frequent malignancies among individuals infected by HIV. Diffuse large B-cell lymphoma remains a leading cancer after the introduction of combined antiretroviral therapy (cART). The incidence of other lymphomas including Burkitt lymphoma, primary effusion lymphomas, and plasmablastic lymphoma of the oral cavity remain stable, while the incidence of Hodgkin lymphoma and Kaposi sarcoma-associated herpesvirus (KSHV)-associated Multicentric Castleman Disease has increased. The heterogeneity of lymphomas in individuals infected by HIV likely depends on the complexity of involved pathogenetic mechanisms, i.e. HIV-induced immunosuppression, genetic abnormalities, cytokine dysregulation, co-infection with the gamma-herpesviruses, Epstein Barr virus and KSHV, and the dysregulation of the immune responses controlling these viruses. In the modern cART era, standard treatments for HIV-associated lymphoma including stem cell transplantation in relapsed/refractory disease, mirrors that of the general population. The combination of cART and anti neoplastic treatments has resulted in remarkable prolongation of long-term survival. However, oncolytic and immunotherapic strategies, and therapies targeting specific viral oncogenes will need to be developed primarily.
Neighborhood disadvantage, household chaos, and personal stressors: exploring early-life contextual factors and current mental health symptoms in college students

Abstract Objective Using Bronfenbrenner’s socio-ecological model as a frame, we explored the impact of neighborhood disadvantage, household chaos, and personal stressors on current mental health symptoms in college students. Participants 144 students at a large, public university in the southern U.S. Methods Participants completed measures of demographics, family-of-origin household chaos, stressors, anxiety, and depression, and provided their childhood home ZIP code. Using U.S. Census Data, four structural indicators of neighborhood disadvantage were extracted and appended to each participant’s ZIP code. Results Hierarchical regression revealed that all three variables predicted anxiety symptoms. However, only household chaos and personal stressors predicted current depressive symptoms. Unexpectedly, greater neighborhood disadvantage predicted lower levels of current anxiety. Mediation analyses demonstrated that personal stressors partially mediated the relationships between household chaos and mental health symptoms. Conclusions College administration and counseling centers may wish to consider pre-college factors that influence college students’ current anxious and depressive symptoms.
Evidence in disease and non-disease contexts that nonsense mutations cause altered splicing via motif disruption

Abstract Transcripts containing premature termination codons (PTCs) can be subject to nonsense-associated alternative splicing (NAS). Two models have been evoked to explain this, scanning and splice motif disruption. The latter postulates that exonic cis motifs, such as exonic splice enhancers (ESEs), are disrupted by nonsense mutations. We employ genome-wide transcriptomic and k-mer enrichment methods to scrutinize this model. First, we show that ESEs are prone to disruptive nonsense mutations owing to their purine richness and paucity of TGA, TAA and TAG. The motif model correctly predicts that NAS rates should be low (we estimate 5–30%) and approximately in line with estimates for the rate at which random point mutations disrupt splicing (8–20%). Further, we find that, as expected, NAS-associated PTCs are predictable from nucleotide-based machine learning approaches to predict splice disruption and, at least for pathogenic variants, are enriched in ESEs. Finally, we find that both in and out of frame mutations to TAA, TGA or TAG are associated with exon skipping. While a higher relative frequency of such skip-inducing mutations in-frame than out of frame lends some credence to the scanning model, these results reinforce the importance of considering splice motif modulation to understand the etiology of PTC-associated disease.
SYNTHESIS AND ANTIDEPRESSANT ACTIVITY OF 2-BROMO-1-(THIETAN-3-YL) IMIDAZOLE-4, 5-DICARBOXYLIC ACID DERIVATIVES

Objective: Synthesis of the salts and diylidenehydrazidеs of 2-bromo-1-(thietan-3-yl) imidazole-4,5-dicarboxylic acid to evaluate the antidepressant activities. Methods: The structures of the synthesised compounds were confirmed by elemental analysis and 1 Н NMR spectral data. The melting points of the compounds were determined on a Stuart SMP30 apparatus. The X-ray diffraction data for compound IIc were obtained at room temperature on a Xcalibur Gemini Еos. The antidepressant activity was investigated in the tail suspension and forced swimming tests. The locomotor activity and anxiety were studied in the open field test. Results: All synthesised compounds showed antidepressant activity after single intraperitoneal injection to male mice at doses equimolar to 10 mg/kg of imipramine. One of the compounds, 2-bromo-1-(thietan-3-yl) imidazole-4,5-dicarboxylic acid di[(4-hydroxy-3-methoxyphenyl) methylidenehydrazide], reduced the anxiety and decreased the locomotor activity at statistically significant levels. Other compounds did not have sedative and/or stimulating effects. Conclusion: Among the synthesised 2-bromo-1-(thietan-3-yl) imidazole-4,5-dicarboxylic acid derivatives, compounds with marked antidepressant activity were identified. An obvious advantage of these products is low toxicity.
Confirmation of species independence and affinity of Musa huangbaioa (Musaceae) – rare endemic banana of China – according to the molecular phylogenetic data

1 Komarov Botanical Institute of the Russian Academy of Sciences, Prof. Popova St., 2, St. Petersburg, 199376, Russia 2 Altai State University, Lenina Pr. , 61, Barnaul, Russia 3 Institute of Botany of Chinese Academy of Sciences, Nanxincun, No.20, Xiangshan, Beijing, China 4 St.-Petersburg State University, Universitetskaya quay, 7−9, St.-Petersburg, Russia 5 ORCID iD: https://orcid.org/0000-0003-2859-9820 6 E-mail: nnosov2004@mail.ru; ORCID iD: https://orcid.org/0000-0002-7096-9242 7 ORCID iD: https://orcid.org/0000-0002-1052-4575 8 ORCID iD: https://orcid.org/0000-0003-3425-1011 9 ORCID iD: https://orcid.org/0000-0003-1146-1622 * Corresponding author
Recurrent Hypoglycemia Due to a High Titer of Insulin Antibody in Response to Exogenous Insulin Administration in Two Cases of Type 1 Diabetes

In the first case, a 60-year-old man who was using continuous subcutaneous insulin infusion (CSII), developed recurrent hypoglycemia due to insulin antibodies. This is the first report of such a case using CSII. In the second case, a 70-year-old man was follow-up case who developed hypoglycemia while using human insulin. In both cases, the hypoglycemia subsided after switching to multiple daily insulin injection and/or insulin preparation. The results of Scatchard analyses of the two cases were similar to those of cases of insulin autoimmune syndrome (IAS) that improved after recovery from hypoglycemia. The clinical characteristics and Scatchard analysis data were essentially the same as those for IAS, except for the presence of insulin administration.
Effectiveness of an optimized text message and Internet intervention for smoking cessation: A randomized controlled trial

Abstract Aims To evaluate the effectiveness of a combined internet and text message intervention for smoking cessation compared with an internet intervention alone. The text message intervention was optimized for engagement in an earlier multiphase optimization (MOST) screening phase. Design A parallel, two‐group, individually randomized clinical trial (RCT) was conducted in a MOST confirming phase. Recruitment spanned December 2018 to March 2019. Follow‐up was conducted at 3 and 9 months, beginning March 2019 and ending January 2020. Setting United States: a digital study conducted among new registrants on a free tobacco cessation website. Participants Eligible individuals were 618 adult current smokers in the United States, age 18 years or older who signed up for text messages during website registration (67.2% female, 70.4% white). Interventions The treatment arm (WEB+TXT; n = 311) received access to the website and text messaging. The control arm (WEB; n = 307) received access to the website alone. Measurements The primary outcome was self‐reported 30‐day point prevalence abstinence (ppa) at 9 months post‐randomization analyzed under intent to treat (ITT), counting non‐responders as smoking. Secondary outcomes included 3‐month measures of 30‐day ppa, intervention engagement and intervention satisfaction. Findings Abstinence rates at 9 months were 23.1% among WEB+TXT and 23.2% among WEB (OR = 1.00, 95% CI = 0.69–1.45; P = 0.99). WEB+TXT increased engagement with 5 of 6 interactive features (standardized mean difference (SMD) = 0.26–0.47, all P < 0.001) and repeat website visits (48.7% vs 38.9%, SMD = 0.14, P = 0.02). Satisfaction metrics favored WEB+TXT (satisfied: 96.3% vs 90.5%, SMD = 0.17, P = 0.008; recommend to friend: 95.9% vs 90.1%, SMD = 0.16, P = 0.028). Conclusions A randomized controlled trial found no evidence that a combined internet and text message intervention for smoking cessation compared with an internet intervention alone increased 9‐month abstinence rates among adult current smokers in the United States, despite evidence of higher levels of intervention engagement and satisfaction at 3 months.
Detection of quaranjavirus-like sequences from Haemaphysalis hystricis ticks collected in Japan.

Viruses belonging to the genus Quaranjavirus in the family Orthomyxoviridae are known as argasid tick-borne viruses. Some viruses in this genus or an unassigned quaranjavirus-like virus have the ability to infect humans although little is known about their pathogenicity. During the surveillance of tick-borne viruses in ixodid ticks in Ehime Prefecture, Japan, novel quaranjavirus-like sequences were detected in three pooled samples of Haemaphysalis histricis nymphs. Phylogenetic analysis revealed that the detected viruses formed a cluster with quaranjaviruses and other related viruses. Specifically, the viruses were closely related to Zambezi tick virus 1 and Uumaja virus, which are quaranjavirus-like viruses recently discovered in ixodid ticks in Africa and Europe, respectively. These findings indicate that the viruses detected in this study were probably a new member of the Quaranjavirus genus or a related group. The viruses were tentatively named Ohshima virus even though only limited sequences of their genome were available. This is the first report on the detection of a quaranjavirus-like virus in the East Asian region. Further investigations are needed to discern its infectivity and pathogenicity against humans or other animals and to determine the potential risk of an emerging tick-borne viral disease.