Miracle-dz/UniFAR-FTUs huggingface dataset:
Bioresorbable scaffolds for the treatment of coronary artery disease: current status and future perspective

Bioresorbable scaffolds represent a novel approach in the treatment of coronary artery disease which allows for vessel wall support without leaving a permanent foreign body in the coronary artery. This technology has the potential to reduce some of the shortcomings of current standard treatment with metallic drug-eluting stents, such as late in-stent restenosis, impaired vasomotion of the stented segment and hindrance of surgical revascularizations. Currently, several bioresorbable scaffolds are available and undergoing clinical or preclinical evaluation. This review will present the current status of development of bioresorbable scaffolds, describe the degradation/resorption process of each device and the clinical data available to date.
Evaluation of telephone health coaching of German health insurants with chronic conditions

Objective: This study aimed to investigate how patients with chronic conditions evaluate telephone health coaching provided by their health insurance company. Methods: A retrospective survey was conducted among coaching participants (n=834). Outcomes included the general evaluation of the coaching, the evaluation of process and effects and the impact on patient-physician communication. Results: Participants’ average age was 66.2 years and the majority were women (58.3%). The majority (78.3%) of the insured persons were satisfied with the coaching and 82.3% would recommend it to others. More than half of the participants (53.3%) had learned about new options to influence their health condition. Sub-group differences in the evaluation of the health coaching were found for age, gender and medical condition. Conclusion: Health coaching might be useful in supporting patients with chronic conditions. While the results indicate a general positive appraisal, a possibility for improvement could be a stronger focus on the individual situation and the imparting of specific skills. Target groups might be selected in a specified manner for the coaching, as older participants in need of specific care seem to benefit less from the approach. Longitudinal and controlled studies are needed to investigate clinical effects of health coaching.
Absorb bioresorbable stents for the treatment of coronary artery disease

Bioresorbable stents are considered to be the ‘fourth revolution’ in percutaneous coronary intervention. The first clinically available Absorb® bioresorbable device is made of poly-l-lactic acid polymer and elutes everolimus. The process of bioresorption is completed in 3 years. The introduction of this device into clinical practice went through several logical phases: first-in-man studies, randomized Absorb II study with moderately complex patients and lesions, registries of real life patient population and reports of challenging cases. The procedural results are excellent; many insights have been gained by intracoronary imaging. Intermediate-term outcomes are very encouraging both from imaging and from clinical perspectives. The issue of increased stent thrombosis rate was raised in one study, but other studies have been reassuring. Excellent lesion preparation, sizing and complete expansion of the Absorb device are crucial for optimal procedural and clinical results. Results of ongoing large randomized studies will determine the future role of this technology.
Confidence Analyses of Self-Interpretation and Self-Description in Depressive Behaviour

The present paper represents an investigation in the procedure to validate a new questionnaire (Salzburg Subjective Behavioural Analysis, SSBA). This questionnaire is based on a new approach to the diagnosis of depressive behaviour. It is hypothesized that a patient suffering from a depressive disorder loses the ability to produce one or more modes of behaviour at a given time and simultaneously has the urge to produce one or more modes of behaviour constantly. Although the patient is capable of describing this behavioural disorder, he/she is unable to interpret it confidently. This inability of interpretation of depressive behaviour assessed with the SSBA may represent a special kind of cognitive impairment in depression that is tested in conducting an analysis of confidence. The analysis of confidence shows that the capability of interpretation in the patient group is significantly impaired. Finally, a discriminant analysis allows to differentiate between depressive behaviour and normal behaviour based on the questionnaire.
Whiplash Injury in Low Speed Car Accidents: Assessment of Biomechanical Cervical Spine Loading and Injury Prevention in a Forensic Sample

Objectives: To evaluate the relationship between motor vehicle collision magnitude and whiplash associated disorder [WAD] outcomes. Methods: The magnitude and characteristics were retrospectively analyzed in 1,096 cases of low velocity collisions between 0 to 20 km/h change of velocity using computer modelling [PC-Crash, MADYMO] to determine the biomechanical stresses upon the occupant's head-neck region. All subjects were involved in litigation, with anticipation of financial gain. The severity of whiplash outcomes were recorded as days off work or self-claimed disability duration. Results: Rear-end collisions were disproportionately high [59%] in reporting WAD compared to general accident occurrence. The commonest cars involved in WAD outcomes were small. The change of velocity [δV] most common for expressing WAD was between 5–10 km/h [49%], and a further 24% had WAD with 0–5 km/h δV. The medium age of complainants was around 30, with 42% at or under this age; the incidence of WAD in the elderly or frail persons with degenerative neck disorders was disproportionately low, 16% being over age 50. About 20% of WAD claims were involved in collisions of sufficient magnitude to realistically cause physical injury to the neck. About 70% were not. Conclusion: In the Munich area, there may be a sub-set of the population among otherwise young healthy persons, who claim compensation for whiplash injury based on minimal if any stresses having been imposed upon their neck. The collision severity and the severity of WAD did not correlate, suggesting that the intensity of external mechanical neck loading is not a reliable marker for WAD claims.
mTHPC-mediated photodynamic detection for fluorescence-guided resection of brain tumors

A most radical resection is of great importance in the treatment of brain tumors, however they can hardly be differentiated from normal brain parenchyma by the naked eye of the neurosurgeon. Photosensitizers are highly selective taken up into malignant tissues, therefore the fluorescence properties of photosensitizers could be utilized for optical differentiation of normal and malignant tissue. Ten patients presenting with brain malignancies were sensitized for photodynamic diagnosis (PDD) and photodynamic treatment (PDT) with 0.15 mg/kg b.w. m-THPC. On day 4 intraoperative PDD and fluorescence guided tumor resection (FGR) was performed, followed by intraoperative PDT. The fluorescence was induced by a xenon lamp at an excitation wavelength ranging from 370 to 440 nm. A sensitive CCD camera was employed for imaging, equipped with a long pass filter to shut off the excitation wavelength and to improve the signal to noise ratio. The pictures are converted digitally by a standard frame grabber and processed in real time and calculated for the tissue auto fluorescence in the emission band of m-THPC at 652 nm. Out of 10 0bservations, two were false negative and 2 were false positive. Our preliminary results indicate that fluorescence guided surgery is feasible and proved to be of significant help in delineating tumor margins and in resection of residual tumor that could not be detected by the surgeon, however the sensitivity and specificity needs to be further improved.
A custom-made scalloped stentgraft to preserve left subclavian artery flow in descending thoracic aortic disease with a short neck

ABSTRACT In thoracic stentgrafting, a short proximal landing zone may necessitate intentional occlusion of the left subclavian artery, which may lead to brain, spinal cord, and left arm malperfusion. A scalloped stentgraft is designed for adequate proximal sealing and preserving the left subclavian artery flow. We performed a systematic review, describe the required pre-operative planning and details of the perioperative technique used and report our own experience. In literature, only 29 patients were reported so far using a proximal scalloped stentgraft. Results show a high technical success rate and low complication rate. These results are comparable to the results from our own institution. From these first small series the scalloped thoracic endovascular aortic repair appears to be a safe and relatively simple solution for thoracic aortic disease involving the left subclavian artery.
A report on operating a nationwide human milk bank in Korea

Purpose: A human milk bank collects, processes, eliminates, and stores breast milk from donors and provides breast milk to those in need. The authors hereby present the experiences and the objective lessons obtained through operating a na- tionwide human milk bank over a period of 2 years. Methods: The characteristics of the donors and the recipients and the amounts of breast milk donated, processed, and received at the East-West Neo Medical Center Human Milk Bank were investigated from August 2007 to August 2009. Results :The donor pool consisted of 131 first-time donors and 39 repeat donors who made 341 and 127 donations, re- spectively. Seventy-nine percent of the donors resided in the Seoul-Kyunggi area, and 60% of the donors were in their 30s. Most information and motivation came from the Internet (66%) or television (14%). A total of 2,736 L of breast milk was collected, and 1,979 L were processed. The cumulative number of recipients was 160 preterm or full-term infants and 21 adults, each group receiving the breast milk 337 and 41 times, respectively. In total, infants received 1,663 L and adults received 179 L. Conclusion :Through the present study, the role and importance of a human milk bank in collecting, pasteurizing, and storing surplus breast milk in through sanitary, medically proven methods and providing this breast milk to recipients could be appreciated and reevaluated. The authors believe that a national support system is necessary to expand this practice to a nationwide scale. (Korean J Pediatr 2010;53:488-494)
Irish staff nurses perceptions of clinical incident reporting

Clinical incident reporting identifies actual and potential risks to patient safety and then eliminates those risks through a system of procedural changes, policy enactment or changes in staff education. This constitutes the first study to explore perceptions of registered nursing staff towards efficacy of clinical incident reporting in Ireland since the launch of the national â€œSTARSwebâ€ incident reporting system in 2004. A survey of 210 nurses using open and closed questions was conducted across three separate acute hospitals in the Irish midlands region. While the majority of participants (90%) had submitted at least one clinical incident report, few received prompt feedback (12%) or prior appropriate training (30%) on this topic. A clear definition of what participants understood of the term â€œclinical incidentâ€ was not evident. However, fear of repercussion or disciplinary action from management was not considered an issue in terms of barriers to reporting. However it is evident that further training in clinical incident reporting is required and modifications to reporting systems at governance level within hospitals are necessary in supporting staff in their work. When considering effective management of clinical incident reporting, managers should ensure that staff nurses receive appropriate feedback and promote the importance of this feedback to enhance clinical incident reporting. Key words: Incident reporting, near miss, risk management, adverse event, clinical, human error.
Multi-tap sliders: advancing touch interaction for parameter adjustment

Research in multi-touch interaction has typically been focused on direct spatial manipulation; techniques have been create to result in the most intuitive mapping between the movement of the hand and the resultant change in the virtual object. However, as we attempt to design for more complex operations, the expectation of spatial manipulation becomes infeasible. We introduce Multi-tap Sliders for operation in what we call abstract parametric spaces that do not have an obvious literal spatial representation, such as exposure, brightness, contrast and saturation for image editing. This new widget design promotes multi-touch interaction for prolonged use in scenarios that require adjustment of multiple parameters as part of an operation. The multi-tap sliders encourage the user to keep her visual focus on the target, instead of the requiring to look back at the interface. Our research emphasizes ergonomics, clear visual design, and fluid transition between the selection of parameters and their subsequent adjustment for a given operation. We demonstrate a new technique for quickly selecting and adjusting multiple numerical parameters. A preliminary user study points out improvements over the traditional sliders.
PHOAKS: a system for sharing recommendations

The feasibility of automatic recognition of recommendations is supported by empirical results. First, Usenet messages are a significant source of recommendations of Web resources: 23% of Usenet messages mention Web resources, and ? >0% of these mentions are recommendations. Second, recommendation instances can be machine-recognized with nearly 90% accuracy. Third, some resources are recommended by more than one person. These multiconfirmed recommendations appear to be significant resources for the relevant community. Finally, the number of distinct recommenders of a resource is a tallying, and redistributing recom-
Semantic queries by example

With the ever increasing quantities of electronic data, there is a growing need to make sense out of the data. Many advanced database applications are beginning to support this need by integrating domain knowledge encoded as ontologies into queries over relational data. However, it is extremely difficult to express queries against graph structured ontology in the relational SQL query language or its extensions. Moreover, semantic queries are usually not precise, especially when data and its related ontology are complicated. Users often only have a vague notion of their information needs and are not able to specify queries precisely. In this paper, we address these challenges by introducing a novel method to support semantic queries in relational databases with ease. Instead of casting ontology into relational form and creating new language constructs to express such queries, we ask the user to provide a small number of examples that satisfy the query she has in mind. Using those examples as seeds, the system infers the exact query automatically, and the user is therefore shielded from the complexity of interfacing with the ontology. Our approach consists of three steps. In the first step, the user provides several examples that satisfy the query. In the second step, we use machine learning techniques to mine the semantics of the query from the given examples and related ontologies. Finally, we apply the query semantics on the data to generate the full query result. We also implement an optional active learning mechanism to find the query semantics accurately and quickly. Our experiments validate the effectiveness of our approach.
Guideline for anti-TNF-α therapy in psoriatic arthritis

Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy with a prevalence between 0.1 and 1% and an equal sex distribution [1]. Psoriasis affects 1–3% of the population, with approximately a third of patients developing PsA [2]. The course of PsA is variable and unpredictable ranging from a mild nondestructive disease to a severe debilitating erosive arthropathy. Erosive and deforming arthritis occurs in 40–60% of PsA patients (followed at hospital clinics), and is progressive from within the first year of diagnosis [3, 4]. The classification of PsA is an area of ongoing international discussion. The five subgroups proposed by Moll and Wright [5] are still frequently used, although considerable overlap between these groups is now recognized. For the purpose of these guidelines we have differentiated between peripheral joint disease in PsA and axial disease alone. Psoriatic spondylitis is similar to ankylosing spondylitis (AS), although it is often less symptomatic, less limiting and radiologically tends to be asymmetrical and less severe [6]. However, despite these differences, until such time as there is evidence that psoriatic spondylitis responds in a different manner from AS to TNFblockade, we recommend that AS guidelines for anti-TNFtreatment are used for the management of psoriatic spondylitis [7]. Much like rheumatoid arthritis (RA), PsA can lead to chronic joint damage, increased disability [8, 9] and increased mortality [10, 11]. Social and financial implications are also important, both in terms of personal loss and the impact of direct (e.g. medical care) and indirect (e.g. inability to work) costs to the state. It is recognized that psoriasis is associated with an increased risk of non-melanoma skin cancers [12], most probably a result of excessive exposure to sunlight and enhanced by use of psoralen and ultraviolet A (PUVA) therapy [13]. The guidelines recognize that these risks that may be potentiated by anti-TNFtreatment and specific recommendations have been made accordingly (see sections headed Exclusion criteria and Monitoring and Toxicity). Need for guideline
Lessons learned from a dementia training programme for health professionals

This paper presents findings from a dementia awareness training programme delivered to a multidisciplinary group of health professionals in the East Midlands, UK in 2012. The training aimed to develop dementia champions and improve care practices. The focus was on the socio-psychological model of dementia. Semi-structured interviews were undertaken with stakeholders (n=5) and training providers (n=2). Post-training questionnaires were completed by those attending the training (n=74). Thematic analysis was undertaken on interview data and open-ended questionnaire data, descriptive statistical analysis was undertaken on quantitative data. Emerging themes focused on the continued need for person-centred care in dementia training and inclusion of the voice of the person with dementia in training material. Attendance of multidisciplinary health professionals at training sessions generated greater understanding of dementia care across professional areas. Issues of health professionals’ workloads and release of staff time were identified as key determinants of staff capacity to attend training. Gaps in training provision were identified.
Use of telemedicine for haemodialysis: perceptions of patients and health-care providers, and clinical effects

Summary In Michigan, the use of telemedicine for dialysis patients began in three centres in 2005. A total of 747 clinical consultations was conducted in the following 22 months. Telephone surveys were conducted with 34 patients and four providers. The patients and providers all had positive perceptions of the telemedicine system and the care that was delivered. Most of the clinical measures of the patients met or exceeded the recommendations made by Renal Network 11. In addition to the clinical work, the telemedicine equipment was used for educational events. Twenty-six professional educational events were provided with a total audience of 105 individuals, and 35 administrative meetings were provided with 286 staff members in attendance. The study showed that patients and providers could participate in educational events that might not be available locally. Despite the success of dialysis telemedicine, the Marquette General Health System discontinued its use in 2007 when the Center for Medicare and Medicaid Services re-affirmed that dialysis centres were not approved sites for telemedicine.
Five-grass-pollen sublingual immunotherapy tablet for the treatment of grass-pollen-induced allergic rhinoconjunctivitis: 5 years of experience

Oralair® (OA) (Stallergenes, Antony, France) is a unique pre- and co-seasonal 5-grass-pollen sublingual immunotherapy tablet launched in 2008, and now approved in 31 countries worldwide for the treatment of grass-pollen allergic rhinitis and rhinoconjunctivitis. OA is the first oral treatment with a consistent, well-balanced allergen extract that mimics natural exposure and sensitization. A wealth of data exists from over 5 years of clinical and real-world experience demonstrating the efficacy and safety of OA for grass-pollen-allergy treatment. OA is highly effective from the first pollen season in all patient subgroups, including children and those with comorbid mild asthma, irrespective of sensitization status and symptom severity. OA also has sustained long-term benefits for symptom control and quality of life. This article provides an overview of the pharmacodynamics and pharmacology of OA; its efficacy, safety, tolerability and cost–effectiveness for the treatment of allergic rhinitis and rhinoconjunctivitis and its role in clinical practice.
Tillfrisknande och användning av hästar med fång

Laminitis has crippled horses through times and many cures have been used to treat it. Since the mechanism of the disease is yet not fully understood, treatments are only ways to alleviate the pain and at best, slow down the pathological process enough to make time for improvement. This paper is a retrospective study of 71 horses treated by a protocol at Hastsjukhuset Stromsholm. The protocol implies three visits at zero, five and fifteen weeks. At each the horse is evaluated and treated by a veterinarian. Lateromedial x-rays are taken and the farrier performs a dorsal hoof wall resection when appropriate. Resection of the dorsal hoof wall is a technique used with favorable results in several countries (Peremans et al 1991, Eustace & Caldwell 1989). It has however not been used in Sweden to a greater extent. Between the first two visits the horse is kept in strict confinement. If necessary the horse is hospitalized and analgesics are used whenever called for. The horses included were declared sound at least six months prior a telephone interview was conducted. During the interview notes were taken on how the convalescence work had proceeded and whether the horse had been able to return to its previous workload. Of the 71 animals 39 had recovered completely. 47% of the ponies regained full soundness and so did 75% of the horses. Significance for prognosis was tested with a binary regression laminitis, cause, number of feet involved, body condition, radiographic findings and two types of clinical scoring. Significance was proven for age insofar as the outcome was worse the older the horse. Distribution according to sex was even among the patients, but the maresran a higher risk of non-recovery. Horses and ponies in good body condition were well represented among the patients. They regained full soundness to a greater extent than animals in normal body condition. No statistical significance could be proven for the clinical evaluation systems. A certain misinterpretation of the clinical notes could have happened in the adaptation, but this probably illustrates the owner's big part in the outcome. Motivation, patience and economical possibilities seem to matter as much as the clinical picture. Horses with a previous history of laminitis do not recover to a lesser extent, but are retired or put down more frequently.