Miracle-dz/UniFAR-FTUs huggingface dataset:
11β-Hydroxysteroid dehydrogenase type 1 and bone

Summary Intracellular enzymatic metabolism of glucocorticoids is an important contributor to glucocorticoid action. The most extensively studied glucocorticoid metabolising enzymes are the 11β-hydroxysteroid dehydrogenases (11β-HSDs). These enzymes interconvert hormonally inactive glucocorticoids such as cortisone and dehydrocorticosterone with their active counterparts cortisol and corticosterone. 11β-HSDs have been reported to be expressed in bone and bone cells. This article reviews the literature relating to the expression, activity and functional consequences of 11β-HSD expression in bone. This activity appears to have clinical consequences in terms of predisposition towards osteoporosis and fracture and in the variation between individuals in the sensitivity of bone to therapeutic glucocorticoids. The existence of this enzyme system within bone opens up opportunities for new treatments to protect bone from the adverse effects of glucocorticoids.
Quantifying poached wildlife mammal species in Center-western region of Cte dIvoire

Poaching or illegal hunting of wildlife for bushmeat is common in Cote d’Ivoire and particularly in center-western regions where it is actually a major income source contrary to traditional livelihood need. In order to assess the threat and impact of illegal bushmeat off take on sustainable biodiversity and conservation of wildlife resources to fill the information gap we examined the quality and quantity of extracted wildlife fauna for bushmeat in these regions from September 2018 to April 2019. Forty- seven bushmeat data collection sites were considered. Data collection was designed to collect information on the species poached, quantity, sex of poached animals, age estimate as well as poaching methods. A total of 352 wildlife mammals corresponding to 8 orders and 18 species was collected from bushmeat traders and markets. The order of rodents comes largely in the lead with more than half of the specimens encountered that is, 67.05% and the grass cutter species, Thryonomys swinderianusis the most poached and the only one found in all the sites investigated. A significant sex-specific pressure (p<0.009) was noted. Despite 77.78% of the species collected are classified minor concern, it is undeniable that the conservation status of wildlife biodiversity will always be threatened by illegal hunting. It is therefore up to the state authorities to officially cover hunting with clear control measures for the sustainable management of wildlife biodiversity. Key words: Bushmeat, illegal hunting, poaching, biodiversity, wildlife, harvest, conservation.
A Review of Dynamic Capabilities, Innovation Capabilities, Entrepreneurial Capabilities and Their Consequences

The paper proposes a conceptual model which provides direction for researchers to empirically establish the connections between dynamic capabilities, innovation capabilities, entrepreneurial capabilities and financial and strategic performance. The author uses systematic literature review process to select the articles used in this study. First, the present paper review and discuss some major contributions to the theories of dynamic capabilities, innovation capabilities, entrepreneurial capabilities and their consequences. The author seeks to highlight different understandings of the concepts to clarify the distinctions between them. Second, the conceptual model and propositions for future studies were developed. The proposed model highlights the different measures of dynamic capabilities, innovation capabilities, entrepreneurial capabilities and their consequences. The model with its associated propositions was developed base on limitations and gaps observed from past studies. It is focused on empirically testing the direct impact of dynamic capabilities, innovation capabilities, and entrepreneurial capabilities on the performance of SMEs in Vietnam. Nevertheless, the proposed model can be applied to similar situations in different contexts and countries. Further empirical testing of proposed model would contribute to enriching existing knowledge of dynamic capabilities, innovation capabilities and entrepreneurial capabilities within SMEs and how these capabilities foster superior performance.
Polytechnic Students' Mathematical Thinking Processes in Linear Algebra: A Qualitative Approach

The main challenge in teaching is to build experiences that include students and promote their thinking processes required to make meaning of those experiences. Thinking is unique for human beings and is characterized as a continuous rebuilding of high-level mental abilities that are consciously developed over time to create a more sophisticated structure of knowledge. The polytechnic curriculum is generally aimed at training students to become engineering technicians as well as critical thinkers; and at the same time assume personal responsibilities in exercising technical judgments that may contribute to the needs, expectations and growth of the diverse economy of any nation. This study adopts a qualitative approach using thematic analysis to explore polytechnics students' mathematical thinking processes (MTPs) in linear algebra based on Mason's approach. The researchers interviewed seven students; and the selection of the students for the interview was based on their posttest scores previously published in our quantitative study consisting of two students who achieved the highest scores, three students who achieved moderate scores and two students who achieved the least scores. A semi structured interview was used to acquire rich and detail insight in the students' understanding with regards to their MTPs. Deductive coding method was used to generate codes and themes from the interview data as the verbatim quotes of each student are examined. Results of this study showed development of MTPs among the students with respect to specializing, generalizing and conjecturing while convincing shows a non-significant result.
Mechanochromic double network hydrogels as a compression stress sensor

Tough double network (DN) hydrogels were prepared with various contents of rhodamine (Rh) mechanophores (0.3, 0.5, and 1.0 mol%) that undergo colour changes from colourless-to-pink with external stresses. We further demonstrated a facile platform between the colour changes and external stresses through converting photographs to mechanographs.
What Is Aging in Place? Confusions and Contradictions

ABSTRACT Aging in place is a policy goal for many governments and a personal goal for numerous older people. But what does it mean? Drawing on both scholarly and gray literature, this article outlines seven themes underlying definitions of aging in place. Some are descriptive: never moving, staying put for as long as possible, or remaining in the same vicinity. Two are related to care: staying out of a nursing home or receiving progressively higher levels of care in the same residential care facility without moving. Others are more normative approaches: aging in place as a policy ideal or as an exercise of choice. Definitions have implications for policy debates, urban planning activities, development approaches, and personal decisions. Recognizing that the term has many different definitions and nuances will help clarify policy, planning, and development options.
Towards an Auditable Cryptographic Access Control to High-value Sensitive Data

We discuss the challenge of achieving an auditable key management for cryptographic access control to high-value sensitive data. In such settings it is important to be able to audit the key management process - and in particular to be able to provide verifiable proofs of key generation. The auditable key management has several possible use cases in both civilian and military world. In particular, the new regulations for protection of sensitive personal data, such as GDPR, introduce strict requirements for handling of personal data and apply a very restrictive definition of what can be considered a personal data. Cryptographic access control for personal data has a potential to become extremely important for preserving industrial ability to innovate, while protecting subject's privacy, especially in the context of widely deployed modern monitoring, tracking and profiling capabilities, that are used by both governmental institutions and high-tech companies. However, in general, an encrypted data is still considered as personal under GDPR and therefore cannot be, e.g., stored or processed in a public cloud or distributed ledger. In our work we propose an identity-based cryptographic framework that ensures confidentiality, availability, integrity of data while potentially remaining compliant with the GDPR framework.
Impregnação de bactérias probióticas em melão minimamente processado

10 1. INTRODUÇÃO . 12 2. OBJETIVOS . 14 2.1. Objetivo geral . 14 2.2. Objetivos específicos . 14 2. REVISÃO DE LITERATURA . 15 2.1. Vegetais Minimamente Processados . 15 2.1. 1. Melão . 17 2.2. Probióticos . 19 2.3. Impregnação a Vácuo . 21 2.4. Imersão . 25 3. MATERIAL E MÉTODOS . 26 3.1. Esquema do experimento . 26 3.2. Matéria Prima . 27 3.3. Processamento mínimo de melão . 27 3.4. Bactérias probióticas utilizadas e preparo da solução probiótica . 27 3.5. Determinação do tempo de impregnação a vácuo (IV) . 28 3.6. Impregnação à vácuo. 28 3.7. Impregnação a pressão atmosférica (imersão) dos melões em solução probiótica . 29 3.8. Avaliação da viabilidade de L. acidophilus e de L. plantarum em melão minimamente processado . 29 3.9. Análises físico-químicas . 29 3.9. 1. Determinação de pH, acidez total titulável e sólidos solúveis totais . 30
Time-varying coefficient cumulative gap time models for intensive longitudinal ecological momentary assessment data with missingness

Ecological momentary assessment (EMA) studies investigate intensive repeated observations of the current behavior and experiences of subjects in real time. In particular, such studies aim to minimize recall bias and maximize ecological validity, thereby strengthening the investigation and inference of microprocesses that influence behavior in real-world contexts by gathering intensive information on the temporal patterning of behavior of study subjects. Throughout this paper, we focus on the data analysis of an EMA study that examined behavior of intermittent smokers (ITS). Specifically, we sought to explore the pattern of clustered smoking behavior of ITS, or smoking ‘bouts’, as well as the covariates that predict such smoking behavior. To do this, in this paper we introduce a framework for characterizing the temporal behavior of ITS via the functions of event gap time to distinguish the smoking bouts. We used the time-varying coefficient models for the cumulative log gap time and to characterize the temporal patterns of smoking behavior, while simultaneously adjusting for behavioral covariates, and incorporated the inverse probability weighting into the models to accommodate missing data. Simulation studies showed that irrespective of whether missing by design or missing at random, the model was able to reliably determine prespecified time-varying functional forms of a given covariate coefficient, provided the the within-subject level was small.
The Relation Between Physical Activities and the Occurrence of Dysmenorrhea

Background : According to a research conducted in Palestine, there are 85.1% university students reportedly having pain during menstruation. The occurrence of dysmenorrhea in Indonesia is 86%. The high occurrence of dysmenorrhea has less attention from the public and even from the adolescents themselves. One of the factors that influence the occurrence of dysmenorrhea is physical activities. Women who do not do exercise regularly have 3.48 times of risk to experience dysmenorrhea. This study aims to reveal the correlation between physical activities and dysmenorrhea. Method: This was quantitative research with cross sectional design. The population in this study was 136 female students of D4 Medical Laboratory Technology study program. Sixty eight respondents were contributed in this study with exclusion and inclusion criteria. The sampling technique used was total sampling. Bivariate analysis used was the Fisher’s Exact correlation test. The research hypothesis was there was a correlation between physical activities and the occurrence of dysmenorrhea. Results: There were 51 respondents who experienced dysmenorrhea (75%) and there were 53 respondents who were categorized at moderate physical activities obtained p < 0.05). Conclusion: It can be concluded that there is a relation between physical activities and dysmenorrhea
A challenge in teaching scientific communication: academic experience does not improve undergraduates’ ability to assess their or their peers’ writing

Abstract Introducing undergraduates to the peer-review process helps them understand how scientific evidence is evaluated and communicated. In a large biology course, technical writing was taught through mock peer-review. Students learned to critique original research through a multistep framework, calibrating their assessment skills with class standards. We hypothesized students’ assessment of their own and their peers’ writing becomes more accurate as they gain academic experience, and that novice students are more overconfident in their writing abilities. Counter to many instructors’ assumptions, our results indicated that regardless of level of academic experience, students’ self-assessed grades were higher than peer-assessed grades (p < 0.01). Both self- and peer-assessed grades were significantly higher than the instructor’s grade (p < 0.01). Overall, the peer-review exercise was positively viewed by students. Most students found the peer-review process beneficial, and 88% reported taking it seriously, despite knowing they would receive instructor’s feedback at the final stage of the writing exercise. Ultimately, the peer-review process provides an effective way to teach technical writing to undergraduates, but instructors should not assume that returning students with greater academic experience are better judges of their own performance. This study illustrates that all students are equally challenged to accurately assess the quality of their own work.
İşe Angaje Olma ve Algılanan İçsellik Statüsü İlişkisinde Çalışan Sesliliğinin Aracı Rolü

Pozitif orgutsel davranis konulari arasinda yer alan ve calisma iliskilerinde calisanlarin rol gereklerinin bir sonucu olarak ortaya cikan ise angaje olma, calisanlarin performanslari basta olmak uzere bircok orgutsel sonuc uzerinde etkisi bulunan bir davranis turudur. Bu nedenle calisanlarin orgutlerdeki rol gereklerinin hangi onculler tarafindan belirlendiginin arastirilmasi onem tasimaktadir. Ise angaje olmanin onemli onculleri arasinda calisan sesliligi gelmektedir. Algilanan icsellik statusu ise orgutsel davranis yazinindaki calismalarda nispeten daha az ilgi gorse de ise angaje olmanin bir diger onemli onculudur. Bu kapsamda bu calismanin amaci, algilanan icsellik statusunun ise angaje olma uzerindeki etkisinin incelenmesi ve bu iliskide calisan sesliliginin etkisi olup olmadiginin arastirilmasidir. Arastirmada Konya ornekleminde bilisim sektorunde calisan 403 calisandan basit tesadufi ornekleme yoluyla anket yontemi ile veri toplanmistir. Arastirma degiskenlerini olcumlemek icin ise angaje olma olcegi (Schaufeli ve Bakker, 2003), calisan sesliligi olcegi (Van Dyne ve Le Pine, 1998) ve algilanan icsellik statusu olcegi (Stamper ve Masterson, 2002) kullanilmistir. Orneklemden elde edilen veriler yapisal esitlik modeli ile ve SPSS 23.0 ve AMOS 22.0 paket programlari araciligiyla analiz edilmistir. Arastirma sonucunda algilanan icsellik statusunun ve calisan sesliliginin ise angaje olma uzerinde pozitif yonlu ve istatistiksel bakimdan anlamli bir etkisi oldugu tespit edilmistir. Benzer sekilde algilanan icsellik statusunun calisan sesliligi uzerindeki etkisinin de pozitif yonlu ve istatiksel bakimdan anlamli oldugu gozlemlenmistir. Ayrica calismada algilanan icsellik statusu ve ise angaje olma arasindaki iliskide calisan sesliliginin kismi aracilik rolune sahip oldugu sonucuna ulasilmistir. Bu dogrultuda, yuksek duzeyde icsellik statusu algisina sahip calisanlarin orgutsel uygulamalara daha fazla katilim saglayarak seslilik davranislarini artacagini ve bu durumun bir sonucu olarak calisanlarin rol gereklerine angaje olacaklari ifade edilebilir.
A projected Bouligand–Landweber iteration for non-smooth ill-posed problems

In this work, we formulate a projected Bouligand–Landweber iteration for non-smooth ill-posed problems. The approach is a combination of Bouligand–Landweber iteration and the projection onto stripes the width of which is controlled by both the noise level and the structure of the operator. Since the forward mapping is not Fréchet differentiable, the convergence analysis will be based on the concept of asymptotic stability and a generalized tangential cone condition. Finally, numerical examples will be presented.
Bidirectional changes of hepatic and peripheral insulin clearance characterize abnormal temporal patterns of serum insulin concentration in diabetic subjects

Insulin plays a central role in glucose homeostasis, and impairment of insulin action causes glucose intolerance and leads to type 2 diabetes mellitus (T2DM). A decrease in the transient peak and sustained increase of circulating insulin by glucose infusion accompany T2DM pathogenesis. However, the mechanism underlying this abnormal temporal pattern of circulating insulin concentration remains unknown. Here we show that bidirectional changes of hepatic and peripheral insulin clearance characterize this abnormal temporal pattern of circulating insulin concentration during the progression of T2DM. We developed a mathematical model using a hyperglycemic and hyperinsulinemic-euglycemic clamp in 111 subjects, including healthy normoglycemic and diabetic subjects. The hepatic and peripheral insulin clearance significantly increase and decrease, respectively, during the progression of glucose intolerance. The increased hepatic insulin clearance reduces the amplitude of circulating insulin concentration, whereas the decreased peripheral insulin clearance changes the temporal patterns of circulating insulin concentration from transient to sustained. These results provide insight that may be useful in treating T2DM associated with aberrant insulin clearance.
On the simulation of the hysteresis loop of polycrystalline PZT thin films

We investigate experimentally and numerically the polarization hysteresis loop of a PZT thin film utilized in MEMS actuators. A fully coupled electromechanical phase-field technique is employed for the numerical prediction part, starting from a simplified model of the thin film proposed on the basis of several experimental evidences. It is shown that polycrystalline nature of the film plays a fundamental role. In particular the simulations demonstrate that grains with dielectric interfaces and stochastic orientation of the crystallographic directions have a significant impact on the overall hysteresis loop.
Preliminary study on phylogeny of Barbus genus in the Po River

RIASSUNTO Studio preliminare della filogenesi del genere Barbus nel fiume Po Il genere Barbus è caratterizzato da una complessa struttura tassonomica. Nel distretto ittiogeografico Padano-Veneto sono state identificate due specie autoctone: Barbus caninus, specie prettamente reofila, e Barbus plebejus, reofilo anch’esso, ma distribuito più a valle rispetto al primo; entrambi risultano presenti nel Fiume Po. Al fine di valutare le relazioni filogenetiche di queste due specie di barbo è stato effettuato uno studio preliminare tramite il sequenziamento del gene del citocromo b (1103 pb) del DNA mitocondriale. Gli alberi filogenetici ottenuti sono stati integrati e confrontati con i dati molecolari disponibili in GenBank.
Personalized external aortic root support.

OBJECTIVES Implantation of a personalized external aortic root support (PEARS) can prevent dilatation of the aortic root and ascending aorta in patients with aortopathy of various aetiologies. Because PEARS is an emerging technology, all aspects concerning indications, surgical technique and safety should be elucidated. Our goal was to summarize all of these aspects so that physicians and patients would have sufficient information to evaluate this alternative approach. METHODS Between April 2004 and March 2020, 317 patients underwent PEARS operations at 25 surgical centres in 9 countries. RESULTS The most common indication was Marfan syndrome (57%). The single perioperative death represented a mortality of 0.3%. The long-term experience comprises 871 patient/years with 1 patient living for 15 years and 19 patients living for more than 10 years. CONCLUSIONS PEARS seems to be a promising method of treatment of dilatation of the aortic root and/or ascending aorta. Multicentre observational studies are needed to gain more experience because this operation is still uncommon and the number of operations per surgeon/centre is low.
The Effect of Capital Structure on Financial Performance with Firm Size as a Moderating Variable of Non-Financial Firms Listed at the Nairobi Securities Exchange

This paper examines the effect of capital structure on the financial performance of the non-financial firms listed at the Nairobi Securities Exchange and how this relationship is moderated by firm size. In addition, the paper evaluates the existence of equilibrium and disequilibrium relationship among the variables. The study analyzed unbalanced panel data sourced from across 53 non-financial firms listed at the Nairobi Securities Exchange which covers the period from 2010 to 2017. Total debt to total equity, total equity to total assets, and total debt to total assets were used for assessing capital structure of the listed non-financial firms. Firm size was measured using natural logarithm of total sales. Financial performance attribute was measured by Tobin’s Q. Data was analyzed using descriptive statistics, multiple and simple regression analysis. Regression analysis was used to ascertain the direction and magnitude of the relationships. The study revealed that leverage had a significant positive effect on the financial performance of the NSE listed non-financial firms. Furthermore, firm size has a positive moderating effect on the relationship between capital structure and financial performance. The study concludes that firms should strive to increase their leverage since it has a statistically significant positive effect on financial performance of the nonfinancial firms listed on the NSE. The study further concludes that firms should strive to grow their firm size by increasing their total sales. This is because it has a statistically significant positive effect on the financial performance of NSE listed non-financial firms.
Loneliness is associated with the subjective evaluation of but not daily dynamics in partner relationships

Loneliness describes a perceived deficiency in quantitative or qualitative aspects of individuals’ social relationships. Whereas the health-related consequences of loneliness are well-documented, surprisingly little is known about its interpersonal features and its consequences for relationship outcomes. In the present study, we investigated the association between loneliness and relationship experiences in partner relationships with a sample of 937 individuals from 480 mixed-sex couples. By employing actor-partner interdependence models and dyadic cross-lagged moderated multilevel models, we found higher loneliness to be robustly related to (a) lower relationship satisfaction for both oneself and the partner, (b) more self-reported, but not partner-reported conflicts, (c) lower average levels of one’s own, but not the partner’s closeness, and (d) less own self-disclosure. In contrast, loneliness was not associated with (a) sexual contact frequency, (b) average levels of physical affection, or (c) the daily dynamics between closeness and self-disclosure/physical affection. Thus, the results of the present study indicated that loneliness is primarily associated with the perception of the partner relationship but not its rather objective features or daily dynamics.