Miracle-dz/UniFAR-FTUs huggingface dataset:
Ochrobactrum anthropi Bacteremia in a Child with Inborn Error of Mitochondrial Fatty Acid Oxidation

Objective: To report an incident of bacteremia caused by Ochrobactrum anthropi.Case Presentation and Intervention: The case of a female child aged 2 years and 10 months with a known history of long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency who developed O. anthropi bacteremia during hospital stay is presented. Patient’s history, clinical findings, laboratory and radiological investigations were thoroughly reviewed. The cultured organism was identified using MicroScan WalkAway 96 SI (Dade Behring) as well as by conventional techniques. Imipenem resistance was confirmed by the conventional Kirby-Bauer disk diffusion technique on Muller-Hinton agar with no zone of inhibition around a 10-µg imipenem disk (Hi Media) using the 0.5 McFarland standard. Conclusion: This report shows O. anthropi as a rare nosocomial pathogen that affected a patient who was immunocompromised. The O. anthropi showed multidrug resistance.
Development of simulation methods for dielectrics

Small organic molecules, e.g. antioxidants, byproducts or additives, are often present in polymeric materials that are used as insulation in power products. The impact on the performance of the insulation due to these molecules can be significant. In the current study the impact of a polyol (mesoerythritol) on a polypropylene system was studied with the focus on the dielectric permittivity and losses. Material modeling was applied in order to compute these properties for various polyol concentrations. Experiments results were in order to verify the findings of the simulations and the results show that the agreement is very good, especially for the simulations performed in high-resolution. With a so-called multi-scale scheme almost equivalent results was obtained but at significantly lower computational cost. The long term goal is to develop an effective and fast simulation tool.
Toward greater integration of basic and applied behavioral research: An introduction.

The disconnection between basic and applied research in behavior analysis has been lamented for over a decade now (e.g., Deitz, 1978; Michael, 1980; Pierce & Epling, 1980). The articles appearing in this special issue of theJournal ofApplied Behavior Analysis represent a significant step toward increasing the interactions between the basic and applied sectors of our field. These papers cover a wide range of topics and illustrate, in a very practical sense, how basic science discoveries can stimulate the development of behavioral technologies (Mace, 1994). Although this series of articles exemplifies the influence basic research can have on technology, this influence can certainly be bidirectional. That is, specific applied problems that have proven resistant to solution with existing behavioral technologies can occasion the design of laboratory studies to examine the basic behavioral relations that maintain these problems. Such reciprocal influences should be reflected in the cross-citation patterns in JABA and JEAB (i.e., JEAB papers cited in JABA, and vice versa). The article by Poling, Ailing, and Fuqua in this issue reports a recent increase in cross-citations that seems to reflect the growth in basic-applied interactions that this special issue tangibly represents. Our hope is that as these interactions prove to be profitable, basic scientists will also increasingly pose research questions with direct relevance to human problems.
An Integrated Platform for Distributed Resources Monitoring and Software Aging Mitigation in Private Clouds

The use of distributed systems has become increasingly diffused and accessible, especially cloud computing, which is used to deliver computational services to small, medium, and large enterprises. Building and maintaining a private cloud infrastructure may not be trivial, due to requirements of being accessible from anywhere and at any time. Therefore, monitoring and management activities are essential to identify and mitigate failures that may occur, and thus keeping service availability. Several studies show that some failures are caused by a phenomenon called software aging, which refers to the system's degradation during its operational life. This paper describes the design and implementation of the DR Monitor, an integrated platform to monitor and mitigate software aging effects in private cloud computing infrastructures. Several test scenarios demonstrate the operation and effectiveness of this tool, which empowers the proactive management of distributed computing resources.
Involvement of Learners’ Characteristics within the Allocation of Submissions in the context of Peer Assessment in MOOCs

The contribution in the context of this paper relates to the stage of allocating submissions to the assessors within the peer assessment process in MOOCs. We propose an algorithm for the distribution of assignments that involves the learner characteristics related to the evaluation in the methodology of allocating assignments. The inputs of this algorithm are the assessment profiles of learners which include their basic characteristics linked to the evaluation process. The creation of these profiles stands on the use of an assessor model inspired from the literature on learners modeling, a model that we are also discussing in this paper. General Terms E-learning, online education, student assessment, algorithms, learners modeling.
Leveraging Service Discovery in MANETs with Mobile Directories

This paper advances a novel approach that facilitates the location of services and/or digital assets advertised by directories in a Mobile Ad hoc Network. The proposed Service Directory Placement Protocol (SDPP) improves scalability and reduces packet traffic overhead by advancing a multi-directory extension of an earlier approach that relied on the migration of a single directory through the network. This investigation demonstrates that modelling the directory replication problem as a Semi-Markov Decision Problem solved by means of a Reinforcement Learning technique known as Q-learning improves the performance of SDPP. Computer simulations validate the feasibility of the proposed scheme that enables packet overhead reductions between 15 and 75 %, whereas the directory location success rate improves by up to 11% when compared with pure broadcast flooding and other existing approaches in wireless networks where hosts move at walking speeds.
Climate change and the abundance of edible insects in the Lake Victoria Region

Global warming is adversely affecting the earth’s climate and its profound effects are virtually on all ecosystem. Every living animal will be affected in one way or another by climatic changes and insects being an integral biotic component of nearly all ecosystems are not an exemption. However, the various ways by which change will occur is yet to be determined by scientists. Insects being an integral biotic component of nearly all ecosystems will be affected by the change in a variety of ways not yet determined by scientists. This partial review and empirical observation paper discusses how edible lake flies in Lake Victoria and termites in the lake region are responding to climate change and how they are likely to impact on entomophagy and gastrophagy as part of food chain among the riparian communities. The dynamics of the insect population have been observed by several households that collect the insects for domestic purposes. The focus is given to the lake flies (Ephemeroptera and Diptera), termites (Isoptera) and formicidae ants (Hymenoptera) which form part of livestock and human feed. Several factors of climate change are identified and discussed in relation to how they influence insect abundance. Ability to respond successfully to challenges requiring a lot of collaboration across different fields of study is solicited. It requires understanding of all stakeholders, how they will be affected by climate change and strategic adaptive measures open to all. Analysis of impact on humans’ livelihoods with specific focus on developing countries is discussed. The interrelationship in the metamorphosis of entomology and entomophagy in food production in the region is proposed. Key words: Lake flies, termites, climate change, edible insects, entomophagy.
Efficient Measures for Improvement and Optimization of Big Data Hive Queries

Big Data is the term used for representing huge datasets that are not processed using traditional techniques. These days, every sector like Industry, education, hospitals, companies and devices like IOT and Sensors are generating huge amount of data in the order of terabytes, petabytes, yottabytes etc. It is a difficult task to store and analyze the data using traditional RDMS and programming languages. Storing and analyzing big data requires special tools to process the data in an effective manner. Hadoop is one such tool to store and process big data in an efficient way. Map Reduce is a programming model under Hadoop framework which processes the data using < key, value> pairs. But the difficulty level of the programming in the Map Reduce approach, users needs another easy and effective solution to handle big data. Hive is such a solution that processes large amounts the structured data. The environment and commands of hive provide facility to the users easy and flexible query interaction of analyzing big data. But the problem associated with hive is lack of optimization of queries. In this paper, initially, we formulate the approach of map reducer for analyzing big data then discuss problems and difficulty associated with the map reducers. We then discuss implementation and evaluation of Hive queries and then how to create Hive tables with optimized. The results are evaluated using Hadoop Ubuntu Virtual Machine.
Studies on Ester Sulphates 12. Excretion of Sulphate Acceptors in Phenylketonuria

1. The pattern of sulphate acceptors present in the urine of phenylketonurics and control cases was visualized by chromato‐autoradiographic methods, after treatment of urine specimens in a sulphur ‐ylating rat‐liver system in the presence of S35‐labelled sulphate.
Study of Renal Toxicity in Wistar Rats Following the Action of Amphotericin B Solution Prepared under Extreme pH Conditions

Our study related to the renal toxicity of Wistar rats induced by solutions of amphotericin B prepared under extreme conditions of pH (5.4 and 10.8). The results obtained show that with pH 5.4 of stock solution, urea and creatinin rate blood is not disturbed. These means that the renal function is not deteriorated by the amphotericin B. Furthers, treatment of animals infected by the yeast Candida albicans, with the solution of amphotericin B prepared at pH 5.4 and injected at 0.5 mg of AmB/Kg every 24 hours, seems to be effective.
Seismic evidence for a sharp lithospheric base persisting to the lowermost mantle beneath the Caribbean

SUMMARY Broad-band data from South American earthquakes recorded by Californian seismic networks are analysed using a newly developed seismic wave migration method—the slowness backazimuth weighted migration (SBWM). Using the SBWM, out-of-plane seismic P-wave reflections have been observed. The reflection locations extend throughout the Earth’s lower mantle, down to the core–mantle boundary (CMB) and coincide with the edges of tomographically mapped high seismic velocities. Modelling using synthetic seismograms suggests that a narrow (10–15 km) low- or high-velocity lamella with about 2 per cent velocity contrast can reproduce the observed reflected waveforms, but other explanations may exist. Considering the reflection locations and synthetic modelling, the observed out-of-plane energy is well explained by underside reflections off a sharp reflector at the base of the subducted lithosphere. We also detect weaker reflections corresponding to the tomographically mapped top of the slab, which may arise from the boundary between the Nazca plate and the overlying former basaltic oceanic crust. The joint interpretation of the waveform modelling and geodynamic considerations indicate mass flux of the former oceanic lithosphere and basaltic crust across the 660 km discontinuity, linking processes and structure at the top and bottom of the Earth’s mantle, supporting the idea of whole mantle convection.
Characterization, chromosomal localization, and genetic variation of the alpha subunit of porcine eighth component of complement.

The complete amino acid sequence of the porcine alpha subunit of the eighth component of complement (C8A) was determined by characterizing the full length cDNA clone isolated from a porcine liver cDNA library. Porcine C8A was found to be similar to human and rabbit C8A in length, leader sequence, conserved cysteine residues, cysteine-rich modules, and overall sequence. Differences in the amino acid sequence among the three species were detected in the proposed candidate site for CD59 recognition (amino acids 352-389). The porcine C8A gene was physically mapped to chromosome 6q33-35 by in situ hybridization using the porcine bacterial artificial chromosome (BAC) clone as a hybridization probe. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis of C8A was performed using the restriction enzyme Hha I. Distribution of the alleles was determined in pigs (n = 173) of several different breeds. Estimates of allele frequency of the 201 bp fragment were 0.22,. 0.43,. 0.04,. 0.50,. 0.58,. 0.50,. 0.98, and 0.91 in Landrace, Large White, Duroc, Berkshire, Jinhua, Crown Miniature Pig, wild boar, and Meishan, respectively.
Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production

A humanized monoclonal antibody that targets the membrane IgE B cell receptor was associated with improvements in asthmatic airway responses. Asthma Antibody Clears the Air A humanized antibody may be the key for treating allergic asthma. Gauvreau et al. report that quilizumab—a humanized monoclonal antibody that targets the membrane immunoglobulin E (IgE) B cell receptor—led to reductions in total and allergen-specific serum IgE that were sustained for 6 months after dosing and were associated with improvements in allergen-induced early and late asthmatic airway responses. A monoclonal antibody that neutralizes IgE can effectively treat asthma in the clinic; however, use is limited by dosing restrictions and it does not prevent new IgE production. Inhibiting IgE production by targeting membrane IgE–expressing cells may enable more subjects to be treated and less frequent dosing, and has the potential for sustained effects upon the cessation of therapy. Elevated serum levels of both total and allergen-specific immunoglobulin E (IgE) correlate with atopic diseases such as allergic rhinitis and allergic asthma. Neutralization of IgE by anti-IgE antibodies can effectively treat allergic asthma. Preclinical studies indicate that targeting membrane IgE–positive cells with antibodies against M1 prime can inhibit the production of new IgE and significantly reduce the levels of serum IgE. We report results from two trials that investigated the safety, pharmacokinetics, and activity of quilizumab, a humanized monoclonal antibody targeting specifically the M1 prime epitope of membrane IgE, in subjects with allergic rhinitis (NCT01160861) or mild allergic asthma (NCT01196039). In both studies, quilizumab treatment was well tolerated and led to reductions in total and allergen-specific serum IgE that lasted for at least 6 months after the cessation of dosing. In subjects with allergic asthma who were subjected to an allergen challenge, quilizumab treatment blocked the generation of new IgE, reduced allergen-induced early and late asthmatic airway responses by 26 and 36%, respectively, and reduced allergen-induced increases in sputum eosinophils by ~50% compared with placebo. These studies indicate that targeting of membrane IgE–expressing cells with anti-M1 prime antibodies can prevent IgE production in humans.
Personal computer teleradiology interhospital image transmission to facilitate tertiary pediatric telephone consultation and patient transfer: Soft‐tissue lateral neck and elbow radiographs

Although teleradiology systems are available commercially, they are expensive ($30,000), and different makes are incompatible with each other, making them unusable for interhospital image transfers. Standard components were added to a personal computer (PC) to build a functional teleradiology unit capable of interhospital image transmission at a low cost ($600 upgrade). This PC teleradiology system was studied to assess its accuracy in the interpretation of soft-tissue lateral neck x-rays with epiglottitis or retropharyngeal abscesses and elbow x-rays with joint effusions, fractures, or both. A radiologist and a pediatric emergency physician were asked to read the PC teleradiology images. Both physicians read 13 of 13 soft-tissue lateral neck x-rays and 15 of 15 elbow x-rays correctly. This study supports the premise that PC teleradiology can be used to facilitate telephone consultation and patient transfers between tertiary pediatric emergency centers by transmitting pertinent radiographic information over a phone line. Although verbal communication can often suffice in a telephone consultation or transfer, there are many instances when visualizing a radiographic image such as an x-ray or computed tomography scan can provide important information that cannot be optimally described verbally. Rural hospitals can form interhospital image transmission links with tertiary center resources. Tertiary centers may elect to organize interhospital image transmission and referral networks with their rural hospital sources.
Phosphorylation of measles virus nucleoprotein upregulates the transcriptional activity of minigenomic RNA

We report the first identification of phosphorylation sites of the nucleoprotein (N) of the family Paramyxoviridae. The N protein is known to be the most abundant protein in infected cells; it constructs the N–RNA complex (nucleocapsid) and supports transcription and replication of viral genomic RNA. To determine the role of phosphorylation of the N protein, we expressed the N protein of the HL strain of measles virus (MV) in mammalian cells and purified the nucleocapsid. After separation of the C‐terminal region from the core region, phosphorylated amino acids were assayed using MALDI‐TOF/TOF and ESI‐Q‐TOF MS analyses. Two amino acids, S479 and S510, were shown to be phosphorylated by both methods of analysis. Metabolic labeling of the N protein with 32P demonstrated that these two sites are the major phosphorylated sites within the MV‐N protein. In transcriptional analysis using negative‐strand minigenomic RNA containing the ORF of the luciferase gene, mutants of each phosphorylation site showed approximately 80% reduction in luciferase activity compared with the wild‐type N, suggesting that the phosphorylation of N protein is important in the activation of the transcription of viral mRNA and/or replication of the genome in vivo.
Unsupervised delineation of stratum corneum using reflectance confocal microscopy and spectral clustering

Measuring the thickness of the stratum corneum (SC) in vivo is often required in pharmacological, dermatological, and cosmetological studies. Reflectance confocal microscopy (RCM) offers a non‐invasive imaging‐based approach. However, RCM‐based measurements currently rely on purely visual analysis of images, which is time‐consuming and suffers from inter‐user subjectivity.
Separating Figures, Mathematical Formulas And Japanese Text From Free Handwriting In Mixed Online Documents

This paper describes a method for separating online handwritten patterns into Japanese text, figures and mathematical formulas. Today, Tablet PCs and electronic whiteboards provide much larger writing area for pen interfaces unlike PDAs (Personal Digital Assistants), through which users can easily input text, write mathematical formulas and draw figures on the screen. The fact that these objects can be written by a single pen (marker) without switching the device, mode, software or whatever else, and without any writing restrictions such as grids or boxes is one of the most important benefits of the pen interfaces. However, the task of segmenting these objects is challenging. To address this issue, we have applied a probabilistic model employing stroke features, stroke crossings and stroke densities. Further, we partially apply the approach of segmentation by recognition. Although the current recognizer for formulas is not a true recognizer, we have achieved about 81% correct segmentation for all the strokes when applied to our newly prepared database of mixed patterns. This method has been compared with a neural-network. The results show that our method is generally better but less effective in distinguishing figures from other components.
A Bayesian modification to the Jelinski-Moranda software reliability growth model

The Jelinski-Moranda (JM) model for software reliability growth is one of the most commonly cited (often in its guise as the `Musa model? ). Recent studies show that the reliability estimates and predictions given by the model are often grossly inaccurate. It has been suggested that one reason for this poor performance may be the use of the maximum-likelihood method of inference. This paper describes a Bayesian version of the model and shows that it is sometimes an improvement on JM. However, both versions have a tendency to give optimistic answers, probably owing to a key, but implausible, underlying assumption common to both models. The authors conclude that the generally poor performance of the models is such that they should only be used with great caution.
Long-term trends in the incidence of and survival with heart failure.

BACKGROUND Heart failure is a major public health problem. Long-term trends in the incidence of heart failure and survival after its onset in the community have not been characterized. METHODS We used statistical models to assess temporal trends in the incidence of heart failure and Cox proportional-hazards regression to evaluate survival after the onset of heart failure among subjects in the Framingham Heart Study. Cases of heart failure were classified according to the date of onset: 1950 through 1969 (223 cases), 1970 through 1979 (222), 1980 through 1989 (307), and 1990 through 1999 (323). We also calculated 30-day, 1-year, and 5-year age-adjusted mortality rates for each period. RESULTS Heart failure occurred in 1075 subjects (51 percent of whom were women). As compared with the rate for the period from 1950 through 1969, the incidence of heart failure remained virtually unchanged among men in the three subsequent periods but declined by 31 to 40 percent among women (rate ratio for the period from 1990 through 1999, 0.69; 95 percent confidence interval, 0.51 to 0.93). The 30-day, 1-year, and 5-year age-adjusted mortality rates among men declined from 12 percent, 30 percent, and 70 percent, respectively, in the period from 1950 through 1969 to 11 percent, 28 percent, and 59 percent, respectively, in the period from 1990 through 1999. The corresponding rates among women were 18 percent, 28 percent, and 57 percent for the period from 1950 through 1969 and 10 percent, 24 percent, and 45 percent for the period from 1990 through 1999. Overall, there was an improvement in the survival rate after the onset of heart failure of 12 percent per decade (P=0.01 for men and P=0.02 for women). CONCLUSIONS Over the past 50 years, the incidence of heart failure has declined among women but not among men, whereas survival after the onset of heart failure has improved in both sexes. Factors contributing to these trends need further clarification.