Miracle-dz/UniFAR-FTUs huggingface dataset:
IMPROVEMENT OF ANGLE STABILITY BY ADVANCED HIGH SIDE VOLTAGE CONTROL REGULATOR

An advanced High Side Voltage Control (HSVC) regulator which can improve power system angle stability by adding supplemental control to conventional generator excitation system control is developed, the working principle of advanced HSVC and its implementation are given. Comparing the simulation results of advanced HSVC with conventional automatic voltage regulator (AVR), it is shown that by applying HSVC the oscillatory stability of power system can be improved. The advanced HSVC is an effective and reliable measure, in its implementation any feedback signal from the high voltage side of booster transformer is not needed.
If a Tree Falls in the Forest: Presidential Press Conferences and Early Media Narratives about the COVID-19 Crisis

Throughout the COVID-19 crisis, as we confronted questions about social distancing, masking wearing, and vaccines, public safety experts warned that the consequences of a misinformed population would be particularly dire due to the serious nature of the threat and necessity of severe collective action to keep the population safe. Thus, the media and the political elites (e.g., President of the United States) who possess the power to set the information agenda around COVID-19 bear a huge responsibility for the general welfare. Through automated text analysis of complete transcripts of national cable, network, and local news, we explore their narratives surrounding the COVID-19 pandemic and we characterize the differences in which topics were covered and how they were covered by various media sources. Our analysis reveals polarized narratives around blame, racial and economic disparities, and scientific conclusions about COVID-19. Among the various agenda-setting mechanisms available to the president is daily press conferences, which provide a unique opportunity to leverage public exposure, accelerated by the state of crisis. We found both resonance and contrast between the narratives of media and President press conferences. However, as online search data revealed, public information-seeking behavior resemble media coverage more than the President's messages.
Occurrence of antibiotic resistant bacteria and antibiotic resistant genes in rivers found in Anambra state, Nigeria

The study involves the analysis of water samples obtained through simple random sampling (SRS) technique from selected rivers in Anambra State, Nigeria for presence of antibiotic resistant bacteria and antibiotic resisistant genes. The high morbidity and mortality rate among the populace calls for this research. The most probable number (MPN) technique was utilized. Antibiotic susceptibility test, molecular characterization and plasmid profiling tests were carried out. The result of the MPN test indicated that coliform bacteria mostly Escherichia coli occurred predominantly in the water samples connoting effective confirmation of faecal contamination of the rivers. E. coli strains were distinguished by their ability to give colour changes on some lactose broth tubes impregnated with the water samples, surviving high temperatures of 45℃. Antibiotic susceptibility test results revealed that the E. coli isolates were resistant to all the seven antibiotics used namely, clindamycin, gentamycin, ciprofloxacin, erythromycin, sulfonamides, ampicillin and tetracycline. The results of molecular characterization indicated that the most prevalent resistant genes detected in the water samples were the tet A, tet B, sul1 and sul2 of the E. coli strains. The results of the plasmid profiling of the isolates revealed the presence of plasmids on the identified genes. The inferential statistics was employed during data analysis. It was therefore evident that antibiotic resistant bacteria and antibiotic resistant genes occurred in the rivers studied. This then calls for concerted efforts to checkmate this occurrence with a view to promoting the good health of all and sundry.
UTILIZAÇÃO DA LINHA ARTERIAL NA MONITORIZAÇÃO HEMODINÂMICA DO DOENTE CRÍTICO

Enquadramento: Devido a uma considerável evolução tecnológica, a monitorização hemodinâmica realizada com recurso a dispositivos minimamente invasivos, como a linha arterial, a qual se tem mostrado como a referência na avaliação de pressão arterial invasiva, permite a obtenção de dados clínicos fidedignos, minimizando o grau de invasidade dos dispositivos clínicos, maximizando os ganhos em saúde. Objetivo: Analisar a evidência científica existente sobre utilização da linha arterial na monitorização hemodinâmica no doente crítico. Metodologia: Revisão sistemática da literatura (RSL), com análise de artigos publicados entre 2015 e 2022 nas bases PMC, PubMed, B-ON e EBSCO, com descritores MeSH e DeCS, sendo selecionados 14 artigos. Resultados: Os estudos evidenciaram que a utilização da linha arterial permite, para além de parâmetros hemodinâmicos diretos, como os valores de frequência cardíaca, pressão arterial e pressão arterial média, a obtenção de outros valores hemodinâmicos relevantes, sejam eles obtidos através de cálculo, como os valores de débito cardíaco e de volume sistólico, ou obtidos através da combinação entre métodos e dispositivos, como o índice cardíaco ou a compliance arterial, permitindo ainda colheitas sanguíneas frequentes, sem recurso a punções recorrentes. Conclusões: Ficou evidente que a linha arterial, pelo seu baixo grau de invasividade, facilidade de colocação e manuseamento, bem como a sua aplicabilidade clínica em vários campos, é, apesar das suas limitações, considerada atualmente como o dispositivo clínico referência na obtenção, tanto de valores seguros de pressão arterial, bem como de outros dados clínicos fidedignos para a estabilização hemodinâmica do doente em situação crítica.
Computational Fluid Dynamic Evaluation of Deep Inferior Epigastric Artery Perforator (DIEP) Flap End-to-Side Anastomosis

Background End-to-side (ETS) microvascular anastomoses are utilized within deep inferior epigastric artery perforator (DIEP) flap breast reconstruction procedures. Optimization of these anastomoses via a computational fluid dynamic (CFD) model can minimize ischemia and contribute to flap success. Methods A CFD model of a deep inferior epigastric artery to internal mammary artery anastomosis was constructed with OpenFOAM software (OpenCFD Ltd., Bracknell, UK). Blood was modelled as an incompressible Newtonian fluid. Viscosity and density were assumed to be constant throughout the simulation. Mean arterial pressure was held constant at 100 mmHg. Individual virtual meshes were created for 30-, 45-, 60-, 75-, and 90-degree anastomotic angle simulations. Fluid flow was visualized with line integral convolution (LIC) and pure fluid velocity (PFV) techniques. Vessel wall shear stress (WSS) was also visualized. Results The LIC revealed blood recirculation was associated with large anastomotic angles with minimal to no recirculation seen in the 45- and 30-degree simulations. Any recirculation visualized was confined to the toe of the bifurcation. This recirculation was associated with stagnation in the toe of the graft vessel as well, as visualized by the PFV model. A linear relationship was identified between anastomotic angle and percentage of stagnant fluid, with stagnation increasing as the anastomotic angle increased. Wall shear stress increased with the anastomotic angle and was concentrated in the heel and toe of the model. Conclusions The CFD modelling shows that increased acuity of anastomotic angles in ETS DIEP flaps is essential to minimize stagnation, recirculation, and WSS. Successful implementation of this recommendation may directly decrease the risk of flap failure from ischemia.
In Vivo Validation of Diffuse Optical Imaging with a Dual-Direction Measuring Module of Parallel-Plate Architecture for Breast Tumor Detection

We demonstrate a working prototype of an optical breast imaging system involving parallel-plate architecture and a dual-direction scanning scheme designed in combination with a mammography machine; this system was validated in a pilot study to demonstrate its application in imaging healthy and malignant breasts in a clinical environment. The components and modules of the self-developed imaging system are demonstrated and explained, including its measuring architecture, scanning mechanism, and system calibration, and the reconstruction algorithm is presented. Additionally, the evaluation of feature indices that succinctly demonstrate the corresponding transmission measurements may provide insight into the existence of malignant tissue. Moreover, five cases are presented including one subject without disease (a control measure), one benign case, one suspected case, one invasive ductal carcinoma, and one positive case without follow-up treatment. A region-of-interest analysis demonstrated significant differences in absorption between healthy and malignant breasts, revealing the average contrast between the abnormalities and background tissue to exceed 1.4. Except for ringing artifacts, the average scattering property of the structure densities was 0.65–0.85 mm−1.
Leaning Into Digital Dilemmas: How Educators’ Perspectives Can Inform New Civics Education

Background/Context: Digital life raises dilemmas that elude straightforward courses of action. These dilemmas are consequential to civic life, where participatory practices intersect with digital affordances to lend new power, stakes, and public consequences (Kahne et al., 2015). It is essential that students be able to recognize digital dilemmas and grapple with them in nuanced ways before acting (James, 2014). These realities engender calls for redesigning civic education for the digital age (Kahne et al., 2016). Engaging students with complex, authentic dilemmas builds on a rich tradition in moral education (Kohlberg, 1975). For educators on the front lines of this work, reflecting on polarizing digital civic dilemmas is an important precursor to effective classroom facilitation (Hess, 2005). Purpose and Research Questions: Doxing is the use of public social media to reveal personal information about an individual, often with the intent of inviting public shaming for their speech or other actions (Douglas, 2016). Doxing is a signature dilemma of today’s age that surfaces fundamental questions about freedom, privacy, and accountability. The current study examines educators’ varied responses to a doxing dilemma to illustrate how digital civic dilemmas can raise substantive themes for New Civics education. We ask: How do educators respond to a doxing dilemma? What considerations do they raise to justify different stances? Research Design: We draw on data from a larger survey about digital citizenship to examine views of educators (N = 769) who live and work with adolescents in varied contexts throughout the United States and in more than two dozen international contexts. We report on educators’ responses to the doxing dilemma based on an inductive analysis of their open-ended responses. Findings: The focal dilemma is indeed polarizing: 47% (n = 361) of educators surveyed agreed with the doxing case, while 53% (n = 408) disagreed. Respondents’ justifications reveal how the dilemma evokes reflection on the intersections of digital life with reasonable expectations of privacy, the bounds of constitutional rights and legal protections, salient moral principles, the importance of accountability and consequences for actions, and more. Conclusions/Recommendations: As educators are tasked with preparing youth for a New Civics era, we argue that digital civic dilemmas merit use in educator professional development settings and, ultimately, with students. Educators’ perspectives on the doxing dilemma surface diverse considerations, which we reframe as ten questions to guide and deepen engagement.
MicroRNA-145 Impairs Classical Non-Homologous End-Joining in Response to Ionizing Radiation-Induced DNA Double-Strand Breaks via Targeting DNA-PKcs

DNA double-strand breaks (DSBs) are one of the most lethal types of DNA damage due to the fact that unrepaired or mis-repaired DSBs lead to genomic instability or chromosomal aberrations, thereby causing cell death or tumorigenesis. The classical non-homologous end-joining pathway (c-NHEJ) is the major repair mechanism for rejoining DSBs, and the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is a critical factor in this pathway; however, regulation of DNA-PKcs expression remains unknown. In this study, we demonstrate that miR-145 directly suppresses DNA-PKcs by binding to the 3′-UTR and inhibiting translation, thereby causing an accumulation of DNA damage, impairing c-NHEJ, and rendering cells hypersensitive to ionizing radiation (IR). Of note, miR-145-mediated suppression of DNA damage repair and enhanced IR sensitivity were both reversed by either inhibiting miR-145 or overexpressing DNA-PKcs. In addition, we show that the levels of Akt1 phosphorylation in cancer cells are correlated with miR-145 suppression and DNA-PKcs upregulation. Furthermore, the overexpression of miR-145 in Akt1-suppressed cells inhibited c-NHEJ by downregulating DNA-PKcs. These results reveal a novel miRNA-mediated regulation of DNA repair and identify miR-145 as an important regulator of c-NHEJ.
Surface Engineering of Nanomaterials with Polymers, Biomolecules, and Small Ligands for Nanomedicine

Nanomedicine is a speedily growing area of medical research that is focused on developing nanomaterials for the prevention, diagnosis, and treatment of diseases. Nanomaterials with unique physicochemical properties have recently attracted a lot of attention since they offer a lot of potential in biomedical research. Novel generations of engineered nanostructures, also known as designed and functionalized nanomaterials, have opened up new possibilities in the applications of biomedical approaches such as biological imaging, biomolecular sensing, medical devices, drug delivery, and therapy. Polymers, natural biomolecules, or synthetic ligands can interact physically or chemically with nanomaterials to functionalize them for targeted uses. This paper reviews current research in nanotechnology, with a focus on nanomaterial functionalization for medical applications. Firstly, a brief overview of the different types of nanomaterials and the strategies for their surface functionalization is offered. Secondly, different types of functionalized nanomaterials are reviewed. Then, their potential cytotoxicity and cost-effectiveness are discussed. Finally, their use in diverse fields is examined in detail, including cancer treatment, tissue engineering, drug/gene delivery, and medical implants.
The role of siliciclastics in carbonate fabric diversity and preservation: A case study from the Neoproterozoic carbonate − siliciclastic Horse Thief Springs Formation, Death Valley

The sedimentary record of the Pahrump Group in Death Valley comprises well‐exposed successions of mixed carbonate and siliciclastic deposits. Despite the abundance of studies focussing on the depositional dynamics of mixed carbonate – siliciclastic deposition in the Phanerozoic, the record of similar Proterozoic examples is comparatively sparse. Using high‐resolution stratigraphy and microfacies analyses, this study investigates the Tonian Horse Thief Springs Formation within the Pahrump Group of Death Valley, California, in order to propose first‐order constraints on the interplay between carbonate and siliciclastic deposition in the early Neoproterozoic. The mixed successions are unlike many previously studied examples interpreted as being caused by glacio‐eustatic sea‐level changes, thus arguing for a more relevant tectonic influence on siliciclastic deposition. This interpretation is supported by detailed microfacies analyses of siliciclastic‐rich dolostones, which show abundant soft‐sediment deformation features suggesting sudden pulses of sandstone deposition onto a shallow marine carbonate shelf. The Tonian carbonate factory recovered quickly after being smothered by siliciclastics, particularly due to abundant stromatolite growth. A new relationship between siliciclastic input, carbonate fabric diversity, and carbonate preservation is established based on microfacies analyses, putting forward that siliciclastic deposition had a significant impact on the formation and preservation of later‐stage diagenetic dolomite cements, as well as on stromatolite morphology and carbonate fabric diversity within the microbialites. This study shows how repeated siliciclastic incursions had a significant impact on the Proterozoic carbonate factory of the Horse Thief Springs Formation, as well as on diagenetic modification and preservation of shallow marine carbonates, and establishes previously unexplored relationships between carbonate and siliciclastic strata in the Proterozoic.
SOFT WAR IN CYBERSPACE How Syrian non-state actors use hacking to influence the conflict s battle of narratives

V ACKNOWLEDGEMENTS VII CONTENT IX LIST OF FIGURES AND TABLES X INTRODUCTION 1 THE BASICS OF CYBERPOWER: TYPE OF ATTACKS AND KEY TERMS 6 THEORY AND LITERATURE REVIEW 12 IS CYBERWAR COMING? 12 WHAT IS A NON-­‐STATE ACTOR IN CYBERSPACE? 14 GUERRILLA WARFARE AS A STRATEGY IN CONFLICT 16 THE POWER OF THE PERSPECTIVE 19 THE SOFTER VERSION OF WAR 22 METHODOLOGY 26 RESEARCH QUESTION AND KEY ASSUMPTIONS 26 THE CASE STUDY 27 PRIMARY AND SECONDARY DATA COLLECTION 29 STRENGTHS AND WEAKNESSES 31 THE SYRIAN QUESTION: THE HOWS AND THE WHYS IN CYBERSPACE 34 SYRIA AND CYBERSPACE 35 THE MAIN PLAYERS 39 The pro-­‐regime faction: The Syrian Electronic Army 39 The anti-­‐regime faction 42 TRENDS IN SYRIAN CYBER ATTACKS 2011-­‐2014 46 Social media 50 DDoS, defacements of websites and data dump 53 Malware and Spyware 58 THE SYRIAN CYBER BATTLE OF NARRATIVES 61 TESTING THE ASSUMPTIONS IN SYRIA 66 IS IT A SOFT WAR IN SYRIAN CYBERSPACE? 77 FINAL THOUGHTS 82 BIBLIOGRAPHY 84 APPENDIX 93
Identification and stochastic modelling of sources in copper ore crusher vibrations

A problem of rolling element bearings diagnostics for different machines is widely discussed in the literature. Most of the methods are based on the vibration signal analysis. However for some real signals the classical methods of damage detection are insufficient because of the specific nature of examined data. This specific nature is very often manifested through overlapping, mixing or interleaving of processes with different statistical properties and may be the result of different sources that have influence on the analysed signal. The problem of different sources identification and parametrisation of processes which are related to them is very challenging and requires advanced techniques. There are many methods which can be useful in this context however each signal should be analysed separately and there is no universal technique adequate to all possible time series. In this paper we propose a method of sources identification for vibration signal from the heavy duty crusher used in mineral processing plant. A crusher is a kind of machine which use a metal surface to crumble materials into small fractional pieces. During this process, as well as during entering material stream into the crusher, a lot of impacts appear. They are present in vibration signal acquired from bearings housing. Moreover, for some cases we also observe cyclic impulses which may be related to damage of rolling element bearings in the machine. The proposed sources identification method, especially useful for crushers vibrations, is based on the statistical analysis of examined data. Moreover by using advanced techniques of time series theory we propose a stochastic model that exhibits similar statistical properties as analysed signals. The introduced technique can be a starting point to damage detection of rolling element bearings of copper ore crushers.
Order and complexity

The laws of physics govern our lives, and the fundamental constants of Nature (for example, the mass and charge of the electron) define our very morphology. If a human body were totally dehydrated there would only remain about thirty kilograms of crystals and powder, after having removed about fifty litres of water. Yet the amazing machine that is our body functions because of the forces of interaction (attraction and repulsion) that exist between the molecules in that powder when fully hydrated. These forces of interaction are mediated and directed by the vast amount of water that is present. It is the precise orientation of one hydrated molecule with respect to another hydrated molecule, at a well-defined separation, in our central nervous systems that allows a nerve impulse to tunnel quantum-mechanically through the intermediate space between two nerve cells at a synapse. Thereby allowing us to observe our environment, and contemplate our existence. It is the arrangement of the water molecules along molecules of muscle proteins that allows one protein molecule to slide over neighbouring protein molecules, thereby allowing us to do exercise and work, or to hunt and to gather. The precise distances and orientations between the molecules of which our bodies are composed are determined by subtle intermolecular electrostatic forces, whose magnitude is determined by the various constants of Nature, and whose operation is dictated by the laws of physics. We are merely living representations of these immutable physical laws.
Shared Representations for Innovation: Experience Feedback on Two Innovation-oriented Projects

To facilitate the cooperation among the participants of two different innovation projects, we proposed them to rely on specific shared representations: (project #1) the “Service System” and (project #2) the “Unified Framework”. In this paper, we present how these shared representations were experienced in the projects, and bring up a work in progress aimed at better characterizing the effectiveness of shared representations for innovation.
Clinical implementation of routine whole-genome sequencing for hospital infection control of multi-drug resistant pathogens

Background: Prospective whole-genome sequencing (WGS)-based surveillance may be the optimal approach to rapidly identify transmission of multi-drug resistant (MDR) bacteria in the healthcare setting. Materials/methods: We prospectively collected methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), carbapenem-resistant Acinetobacter baumannii (CRAB), extended-spectrum beta-lactamase (ESBL-E) and carbapenemase-producing Enterobacterales (CPE) isolated from blood cultures, sterile sites or screening specimens across three large tertiary referral hospitals (2 adult, 1 paediatric) in Brisbane, Australia. WGS was used to determine in silico multi-locus sequence typing (MSLT) and resistance gene profiling via a bespoke genomic analysis pipeline. Putative transmission events were identified by comparison of core genome single nucleotide polymorphisms (SNPs). Relevant clinical meta-data were combined with genomic analyses via customised automation, collated into hospital-specific reports regularly distributed to infection control teams. Results: Over four years (April 2017 to July 2021) 2,660 isolates were sequenced. This included MDR gram-negative bacilli (n=293 CPE, n=1309 ESBL), MRSA (n=620) and VRE (n=433). A total of 379 clinical reports were issued. Core genome SNP data identified that 33% of isolates formed 76 distinct clusters. Of the 76 clusters, 43 were contained to the three target hospitals, suggesting ongoing transmission within the clinical environment. The remaining 33 clusters represented possible inter-hospital transmission events or strains circulating in the community. In one hospital, proven negligible transmission of non-multi-resistant MRSA enabled changes to infection control policy. Conclusions: Implementation of routine WGS for MDR pathogens in clinical laboratories is feasible and can enable targeted infection prevention and control interventions.