Miracle-dz/UniFAR-FTUs huggingface dataset:
Sleep disorders mediate the link between childhood trauma and depression severity in children and adolescents with depression

Background Childhood trauma is closely related to the onset of depression and more severe depressive symptoms; however, the specific mechanisms are unclear. We aimed to examine the relationship between childhood trauma and sleep disorders in children and adolescents with depression and to explore further the role of sleep disorders in the relationship between childhood trauma and depression severity. Methods A total of 285 children and adolescents with depression completed all scale assessments, including the Childhood Trauma Questionnaire, Self-Reported Insomnia Severity Index and Epworth Sleepiness Scale, and the Center for Epidemiologic Studies Depression Scale. A simple mediation model was used as a theoretical model to examine whether sleep disorders could mediate the relationship between childhood trauma and depression severity. Results Among children and adolescents with depression, childhood trauma is about 78.9%. Compared with patients without childhood trauma, patients with childhood trauma had a higher incidence of sleep disorders (Z = 17.59, P < 0.001), which were characterized by insomnia (Z = 14.45, P < 0.001), not hypersomnia (Z = 2.77, P = 0.096). Different childhood trauma subtypes significantly affected sleep disorders and insomnia (all P < 0.05). Insomnia partially mediated the relationship between childhood trauma and depression severity, and the mediating effect accounted for 35.90%. Conclusion This study found a high rate of concurrent childhood trauma and insomnia among children and adolescents with depression. Insomnia, as a mediator between childhood trauma and depression severity, partially mediates the relationship.
Population dynamics of Citrus tristeza virus (CTV) in single aphid-transmitted sub-isolates of the South African GFMS12 isolate

Grapefruit trees in South Africa have been cross protected against severe stem pitting genotypes of Citrus tristeza virus (CTV) since the 1920s using a mild strain initially called ‘Nartia’ but later referred to as grapefruit mild strain 12 (GFMS12). In the current study, the GFMS12 isolate was used as the source for single aphid transmissions (SAT) using Toxoptera citricida, commonly called the brown citrus aphid (BrCA). The BrCA-transmitted CTV sub-isolates were analyzed by the heteroduplex mobility assay (HMA), serological assays, genetic marker analysis (GMA), and selected sub-isolates were biologically indexed. Reverse transcription PCR of genomic regions was conducted using universal primers followed by cloning the PCR products, HMA and sequence analysis; nine genotypes of CTV were identified in the complex of GFMS12, including both severe and mild genotypes. A single BrCA transmitted up to six CTV genotypes simultaneously in one sub-isolate. The HMA was found to be a rapid, reliable tool for the identification of genotypes and can be useful in the development of CTV management strategies and budwood certification programs.
Association of the serological status of rheumatoid arthritis patients with two circulating protein biomarkers: A useful tool for precision medicine strategies

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints and presence of systemic autoantibodies, with a great clinical and molecular heterogeneity. Rheumatoid Factor (RF) and anti-citrullinated protein antibodies (ACPA) are routinely used for the diagnosis of RA. However, additional serological markers are needed to improve the clinical management of this disease, allowing for better patient stratification and the desirable application of precision medicine strategies. In the present study, we investigated those systemic molecular changes that are associated with the RF and ACPA status of RA patients. To achieve this objective, we followed a proteomic biomarker pipeline from the discovery phase to validation. First, we performed an iTRAQ-based quantitative proteomic experiment on serum samples from the RA cohort of the Hospital of Santiago de Compostela (CHUS). In this discovery phase, serum samples from the CHUS cohort were pooled according to their RF/ACPA status. Shotgun analysis revealed that, in comparison with the double negative group (RF–/ACPA–), the abundance of 12 proteins was altered in the RF+/ACPA+ pool, 16 in the RF+/ACPA– pool and 10 in the RF-/ACPA+ pool. Vitamin D binding protein and haptoglobin were the unique proteins increased in all the comparisons. For the verification phase, 80 samples from the same cohort were analyzed individually. To this end, we developed a Multiple Reaction Monitoring (MRM) method that was employed in a comprehensive targeted analysis with the aim of verifying the results obtained in the discovery phase. Thirty-one peptides belonging to 12 proteins associated with RF and/or ACPA status were quantified by MRM. In a final validation phase, the serum levels of alpha-1-acid glycoprotein 1 (A1AG1), haptoglobin (HPT) and retinol-binding protein 4 (RET4) were measured by immunoassays in the RA cohort of the Hospital of A Coruña (HUAC). The increase of two of these putative biomarkers in the double seropositive group was validated in 260 patients from this cohort (p = 0.009 A1AG1; p = 0.003 HPT). The increased level of A1AG1 showed association with RF rather than ACPA (p = 0.023), whereas HPT showed association with ACPA rather than RF (p = 0.013). Altogether, this study has allowed a further classification of the RA seropositive patients into two novel clusters: RF+A1AG+ and ACPA+HPT+. The determination of A1AG1 and HPT in serum would provide novel information useful for RA patient stratification, which could facilitate the effective implementation of personalized medicine in routine clinical practice.
From a documented past of the Jersey breed in Africa to a profit index linked future

The paper reports on the prevalence and performance of the Jersey cattle breed in Africa, highlighting its geographic distribution and describing the reported performance and other related characteristics from the early 1900s to the present day. The review examines the contribution of Jersey cattle in increasing the volume and efficiency of milk production across the continent. Data relating to the Jersey cattle breed has been reported in more than 30 African countries based on available material published between 1964 and 2020. A key encompassing parameter of any reference was a well-described consideration of the Jersey cattle breed (as pure or crossbred with other exotic and/or indigenous breeds) with reported performance within a variety of production systems and agro-ecologies in Africa. The main focus was on breed and performance parameters, breed types, percentage of different breed types in specific environments, reproduction method and fertility; survival and longevity; disease incidence; and production efficiency metrics such as: feed efficiency (milk unit per dry matter intake, DMI) and milk yield (MY) per unit of body weight (BW). The main performance descriptors identified were based on observations on resilience under both abiotic (heat, nutrition) and biotic (incidences of pests and diseases) stressors, milk production, BW, nutrition and utilisation of feed resources. From the literature consulted, we grouped key dairy cattle performance characteristics reported in each country under the following areas to aid comparisons; a. Milk production (Milk nutrient value, daily MY, lifetime MY and annual MY); b. Fertility traits and AFC; c. Survival and longevity, d. Production efficiency (Feed efficiency, milk per unit BW and milk per unit DMI and e. Disease incidences. Results of the review showed that the smaller stature and lower maintenance nutrient requirements of the Jersey breed means that it is better suited to tolerate the tropical production conditions in the African small-scale dairy farming sector. Detailed analyses on MY and survival showed that Jersey crosses with exotic and African indigenous breeds performed better than purebred cattle with strong evidence to support the suitability of the Jersey breed in crossbreeding with indigenous breeds for use in smallholder production systems.
Ultrastructural analysis of zinc oxide nanospheres enhances anti-tumor efficacy against Hepatoma

Zinc oxide nanomaterial is a potential material in the field of cancer therapy. In this study, zinc oxide nanospheres (ZnO-NS) were synthesized by Sol-gel method using yeast extract as a non-toxic bio-template and investigated their physicochemical properties through various techniques such as FTIR, XR, DLS, and TEM. Furthermore, free zinc ions released from the zinc oxide nanosphere suspended medium were evaluated by using the ICP-AS technique. Therefore, the cytotoxicity of ZnO nanospheres and released Zn ions on both HuH7 and Vero cells was studied using the MTT assay. The data demonstrated that the effectiveness of ZnO nanospheres on HuH7 was better than free Zn ions. Similarly, ZnO-Ns were significantly more toxic to HuH7 cell lines than Vero cells in a concentration-dependent manner. The cell cycle of ZnO-Ns against Huh7 and Vero cell lines was arrested at G2/M. Also, the apoptosis assay using Annexin-V/PI showed that apoptosis of HuH7 and Vero cell lines by ZnO nanospheres was concentration and time-dependent. Caspase 3 assay results showed that the apoptosis mechanism may be intrinsic and extrinsic pathways. The mechanism of apoptosis was determined by applying the RT-PCR technique. The results revealed significantly up-regulated Bax, P53, and Cytochrome C, while the Bcl2 results displayed significant down-regulation and the western blot data confirmed the RT-PCR data. There is oxidative stress of the ZnO nanospheres and free Zn+2 ions. Results indicated that the ZnO nanospheres and free Zn+2 ions induced oxidative stress through increasing reactive oxygen species (ROS) and lipid peroxidation. The morphology of the HuH7 cell line after exposure to ZnO nanospheres at different time intervals revealed the presence of the chromatin condensation of the nuclear periphery fragmentation. Interestingly, the appearance of canonical ultrastructure features of apoptotic morphology of Huh7, Furthermore, many vacuoles existed in the cytoplasm, the majority of which were lipid droplets, which were like foamy cells. Also, there are vesicles intact with membranes that are recognized as swollen mitochondria.
Understanding the complexity of provincial-level elite sport policy change: The case of Shanghai municipality

The analysis of elite sport policy changes at the provincial level remains relatively uncharted territory despite the substantial contributions of provincial-level elite sport to national elite sport success. Data were gathered from semistructured face-to-face interviews and official and semiofficial documents. The key findings were that (1) Guangdong, as a provincial compatriot of Shanghai, has made tremendous efforts and obtained notable achievements in professional football and thus serves as a powerful stimulant for policy reform regarding elite sports in Shanghai; (2) the policy stream has been strengthened by knowledge-based (epistemic) communities at the Shanghai University of Sports that can examine cause and effect relationships and further propose specific policies; and (3) the general director of the Shanghai Administration of Sports plays a central role in advocating for policy proposals. The current research offers practical insights into strategies for reviewing policy trajectories to enhance policy design and implementation.
CEO Power and Relative Performance Evaluation

We model relative performance evaluation (RPE) when a Chief Executive Officer (CEO) has the power to opportunistically influence the design of RPE by choosing the weight on an index-based peer group or by customizing the selection of peers comprising a peer group. A powerful CEO compares the benefits of reducing common risk affecting his compensation with the benefits of receiving a higher bonus by economizing on expected peer-group performance. The Board of Directors (BoD) is less likely to use RPE if a powerful CEO can influence RPE design. Our analytical model yields hypotheses predicting that powerful CEOs choose to reduce common risk only partially and that BoDs choose to not implement RPE if expected peer performance is sufficiently high. Our model has further empirical implications in (1) providing new interpretations of tests for detecting strong-form and weak-form RPE in the presence of powerful CEOs, and (2) suggesting a new empirical measure of CEO power with a focus on the delegation of RPE decision rights.
Jim Cramer’s Mad Money Charitable Trust Performance and Factor Attribution

This article analyzes the complete historical performance of Jim Cramer’s Action Alerts PLUS portfolio from 2001 through 2017, which includes many of the stock recommendations made on Cramer’s TV show, Mad Money. Both since inception of the portfolio and since the start of Mad Money in 2005 (when the portfolio was converted into a charitable trust), Cramer’s portfolio has underperformed the S&P 500 total return index both on an overall returns basis and in Sharpe ratio. Being the first to analyze Cramer’s post-crisis return history, these findings contrast with previous studies, which analyzed Cramer’s outperformance in short windows before the 2008 financial crisis. Using factor analysis, we find that Cramer’s portfolio returns are primarily driven by underleveraged exposure to market returns and, in some specifications, tilting toward small-cap stocks, growth stocks, and stocks with poor earnings quality.
Re-Design of a Serious Game for eHealth

A high fidelity re-design of the serious game ‘Stranded’ was created based on usability evaluations with older adults(55-65 years). The game is designed to be a motivational tool for this target group to perform their physical exercises on a regular basis. This project is to about researching how the usability of this game can be improved by creating a re-design. The UCD- and Creative Technology design process were combined and applied to accomplish this goal. The project consist of two phases which form the iteration cycle for this project: 1) Usability evaluation and analysis and 2) Create a re-design based on results and literature. Usability evaluations were conducted with 10 older adults to find out what issues respondents encounter while playing the game. It was found that the user interface caused most issues, especially with wayfinding and misinterpretation of information. Recommendations were made to solve these issues by conducting an expert review, then they were translated into design solutions. This translation was done by setting prerequisites/limits and validation by literature. The re-design was realized in Unity2D from scratch by implementing the design solutions. It was an iterative process which led to a re-design capable of representing the original game.
SOCIAL ANXIETY – AN INCREASING CHALLENGE FOR EDUCATORS

The traditional lecture has evolved over many centuries, and much research has been done regarding the effectiveness of the traditional lecture. One of the major influences on the lecture format – is the evolving of technology, where books became available for the people, and the resources on the Internet became an interesting player in all educational work. What we as educators must also realise – is that not only the content, learning materials and technology has evolved or changed. Our students have also changed. This paper will discuss these changes with the results of a questionnaire as a basis. The questionnaire was published to around four hundred students, both online based students and campusbased students, and it was based on the Liebowitz Social Anxiety Scale. Two hundred and sixty-four students responded, and over 70% of these students score above 30, which indicates that social anxiety is probable. A somewhat unexpected result is that it applies equally to both groups of students, and the discussion in this paper will seek to explain these results.
Gratitude within ASEAN Higher Education: an exploratory study.

Gratitude can be a powerful mediating variable within relational exchanges, with the potential to drive important relational outcomes. The cultural characteristics of countries within the ASEAN region, suggest that relational exchanges which focus on reciprocity and thus gratitude may have a particularly important role to play. This study seeks to examine evidence of gratitude within students’ and academics’ experiences within four HEIs within Thailand, Vietnam and Indonesia. It examines the impact of gratitude on an important relational outcome, word-of-mouth communication. An understanding of the nature and evidence of gratitude amongst students has the potential to inform the development of strategies aimed to enhance word-of-mouth from students about their experiences of university within the ASEAN region.
Rendimiento de la red sdn dependiendo de la ubicación del controlador openDayLight en una topología, evaluado a través de la plataforma mininet como banco de pruebas

En este trabajo de grado se realizan diversas pruebas para probar el desempeno de la red cambiando la ubicacion del controlador OpenDayLight en diferentes nodos de una red. Lo anterior, se hace con el fin de comparar los retardos presentados para lo que se usa la plataforma Mininet y sus derivados como interfaz grafica para la comprension y entendimiento del diseno. Esto permitira estudiar el problema de la ubicacion del controlador.
Implicit Statistical Learning Across Modalities and Its Relationship With Reading in Childhood

Implicit statistical learning (ISL) describes our ability to tacitly pick up regularities from our environment therefore, shaping our behavior. A broad understanding of ISL incorporates a great range of possible computations, which render it highly relevant to reading. In the light of this hypothesized relationship, ISL performance was explored in young (M = 8.47 years) typical readers (N = 31) across three different modalities (i.e., visual, auditory, and tactile) using the Artificial Grammar Learning (AGL) paradigm. Adopting repeated measures and correlational designs, the obtained data revealed modality constraints: (1) above-chance performance was observed on the visual and tactile tasks but not on the auditory task, (2) there was no significant correlation of ISL performance across modalities, and (3) split-half reliability of visual and auditory tasks was reasonably high, yet for the tactile task it was close to zero. Evaluating the relation between ISL ability and language skills, we observed a positive correlation between visual ISL performance and phonological awareness. We discuss these findings in view of current perspectives on the nature of ISL and its potential involvement in mastering successful (i.e., accurate and fluent) reading.
Eudaimonia, hedonia, and fan behavior: Examining the motives of fans of fictional texts.

Fans of fictional texts engage with the texts of which they are fans in ways that are powerful and complex. What motivates fans to attend to their preferred texts, however, is as yet unclear. In a survey of U.S. adults, participants answered questions about their fan behaviors, the degree to which they identify as fans, and the motives that drive their attention to their preferred texts. Results indicate that fans are motivated by both hedonic and eudaimonic motives, and that stronger motives are associated with stronger fan identification. In addition, both types of motive are associated with engaging in fan behaviors characterized by involvement with the text. Eudaimonic motives are also associated with more fan community engagement, but hedonic motives are only associated with that involvement in concert with fan identification.
PRONÓSTICO DE DEMANDA ELÉCTRICA UNIVARIADA A CORTO PLAZO MEDIANTE APROXIMACIONES ESTADÍSTICAS Y DE INTELIGENCIA ARTIFICIAL. CASO APLICADO A OPERADOR DE SISTEMA DE TRANSMISIÓN FRANCÉS

Short-term load forecasting (STLF) plays a fundamental role in the efficient planning and operation of power systems. Accurate short-term forecasts help with decisions regarding to unit commitment, economic dispatch, maintenance plans and demand response. Several models have been developed to obtain accurate forecasts, however, few of them are freely available to any practitioner. In this work, statistical and artificial intelligence approaches for one day-ahead electricity demand forecasting are compared. To this end, we use free software environment packages that facilitate time series modelling and non-linear model specification. We focus our comparative analysis to univariate forecast techniques that can be established as benchmark for more complex models. To provide an integrated analysis, Exploratory Data Analysis (EDA) is performed and the necessary visualizations to understand the data are provided. All methods are reviewed and compared among each technique using the RTE French database. Deterministic seasonal encoding for the load series is compared to the seasonal differencing approach. Autocorrelation function and mutual information preprocessing procedures are considered to perform feature selection of the artificial intelligence input variables. In the numerical experiments, the average mean absolute percent errors of the best models per technique reviewed were less than 3 %. Double seasonal Holt Winters outperforms all models considering one year as test period. Artificial intelligence models were more accurate when double seasonal differencing was used in the preprocessing stages. This study should be useful to system operators as well as practitioners looking for an introduction to the STLF problem with focus on models at hand.
Effect of Height on Peoples Body Specific Representation and Association between Valence and Space

The body-specificity hypothesis proposes that people with different kinds of bodies tend to think differently in predictable ways (Casasanto, 2009). Previous researches have shown that people tend to make a good judgment on things on the side of their dominant hand which experiences greater motor fluency, and bad judgment on their nondominant side. This conceptual mapping has been shown to be flexible: changing the relative fluency of the hands, or even observing a change in someone else’s motor fluency, results in a reversal of the mapping, such that good things become associated with the side of the nondominant hand (Casasanto & Chrysikou, 2011). The present study consistently tests the body-specificity hypothesis in using people’s height as a test bed. In Casasanto (2009) study, it is shown that about 90% of participants relate “up” with “good”. Is there any different pattern of the association between space and valence among tall and short people? In the present study, we assume that taller people are more likely to make eyes look down and shorter people are more likely to look upward, and the “up is good” effect has interaction with people’s height, which means heights moderate the overall association of good with up. The pre-test is to confirm the premise that taller people feel more comfortable looking down and shorter people feel more comfortable looking up. The experiments are testing whether the association of good with up is weaker in tall people and stronger in tall people. The significant effect is expected to support the body-specificity theory.