Miracle-dz/UniFAR-FTUs huggingface dataset:
Correction of genetic instability of the genome by fractional irradiation of MDBK cells

With respect to given contradictory data in radiobiology, that according to some authors, irradiation of cells of plant and animal origin initiates DNA changes and according to others, repeated irradiation of cells in small doses has a stimulating effect on metabolismwithout increasing the purity of mutations, we conducted the present study, with the aim to study the stability of the genome of MDBK cell line against a background of single and double (fractional) irradiation. The object of the study was a continuous MDBK cell line (Madin-Darby Bovire Kidney Cell, cattle, kidney), which was grown in medium199, manufactured by Federal State Budget Institution FCTRB-ARRVI (Kazan) with 10% bovine serum and the addition of antibiotics (benzylpenicillin sodium salt, kanamycin at 100 units/ml) (streptomycin sulfate at 100 μg/ml) according to standard procedure. A monolayer culture of MDBK cells in the logarithmic growth phase (3-4 days after culture) served as contacting cells. As a result, a radio-modi ied cell line, called MDBK-2, was obtained. Moreover, in an unirradiated MDBK cell culture, the level of chromosomal breakdowns was in the range of 1.03-3.1% with respect to the total number of studied anaphases. Based on the obtained data, it can be concluded, that during prolonged cultivation of MDBK cells, irradiated in a small (adaptive) dose and re-irradiated in 3-minute higher dose (5.95 Gy), there is a signi icant decrease in the yield of aberrant cells, induced by a test dose of γ-rays.
An Examination on the Effects of Technology Acceptance Model in Electronic Human Resource Management

The aim of the current study was to explore the relationship between clarity of electronic human resource management (e-HRM) goals, social influence, apparent usefulness, user satisfaction, user support, apparent ease of use, and mediating conditions and their influence on users’ attitude regarding e-HRM. Accordingly, a sample of 167 HRs from Fortune Global 500 companies in Malaysia were selected. The technology acceptance model (TAM) was used to demonstrate these relationships. The findings revealed that, all the constructs had a positive relationship with each other. Furthermore, apparent ease of use, user satisfaction and apparent usefulness are all essential indicators that reveal the attitude of HR professionals regarding e-HRM usage, thus user education and support are essential processes in e-HRM implementation.
Classification Of Medical Image Data Using K Nearest Neighbor And Finding The Optimal K Value

: Rapid developments made in data mining technologies has explored the growth of real time applications. In general, clustering and classification are the two important tasks used for understanding the hidden patterns of the data. One of the most widely employed algorithm is, k Nearest Neighbor (k NN) which serves better for any classification purpose. This paper proposes a finding of optimal k value using k NN on medical data. Initially, a set of medical images are collected from a public repository. The collected images composed of irrelevant noises, low contrast with degraded quality. Gaussian filtering is employed to reduce the noise with enhanced image quality. The contrast enhanced image is processed under morphological operations in segmentation process. Feature extraction process play a vital role for selecting the optimal k values. Using Gray Level Co-Occurrence Matrix (GLCM), the relevant features are estimated and selected. These selected features are given as input to k NN algorithm and obtains the optimal k value based on accuracy. For a possible set of data folds, the achieved optimal k value dictates the effectiveness of the research objectives.
Knowledge-based Quadratic Discriminant Analysis for phonetic classification

Modeling the second-order statistics of articulatory trajectories is likely to improve the performance in classifying phone segments compared to using only linear combinations of MFCCs. Nevertheless, the extremely high dimensionality of the feature space spanned by a combination of monomials of degree-1 and degree-2 makes it difficult to effectively exploit the discriminative information in the full covariance matrix. This paper proposes a novel algorithm, dubbed Knowledge-based Quadratic Discriminant Analysis (KnQDA), for reducing the number of dimensions of the space spanned by degree-1 and degree-2 monomials by using phonetic knowledge for selecting the set of degree-2 monomials that are most likely to improve classification. KnQDA seeks a trade-off between overfitting and undertraining, which further improves the learnability. Binary classifications on all pairs of phones in TIMIT show the effectiveness of the proposed method, especially on those phone pairs that overlap strongly in the linear feature space.
Nucleation mechanism for 
hcp→bcc
 phase transformation in shock-compressed Zr

We present large-scale atomic simulations of shock-induced phase transition in Zr assisted by the machine learning method. The results indicate that there exists a critical piston velocity of ${U}_{\mathrm{p}}\ensuremath{\sim}0.85\phantom{\rule{0.16em}{0ex}}\mathrm{km}/\mathrm{s}$, above which the product phase has changed from \ensuremath{\omega} to bcc. Unlike the case in Fe, the shock-induced $\mathrm{hcp}\ensuremath{\rightarrow}\mathrm{bcc}$ nucleation mechanism in hcp-Zr single-crystal shows significant dependence on crystal orientation. For shock along the $[10\overline{1}0]$ direction, the hcp phase directly transforms into bcc as expected. However, for shock compression along [0001] and $[1\overline{2}10]$ directions, the $\mathrm{hcp}\ensuremath{\rightarrow}\mathrm{bcc}$ transformation occurs in quite a different manner, i.e., the Zr single crystal transforms into a disordered intermediate that subsequently exhibits ultrafast crystallization of the bcc phase within the timescales of subnanoseconds. We associate such presence of disordered intermediate structure with the sluggishness of shear stress relaxation, which leads to an elastic unstable condition of the crystal during the first few picoseconds of uniaxial compression, and suggests that the fewer possible shear planes (related to Burgers mechanism) for [0001] and $[1\overline{2}10]$ shock loading is an underlying factor for the orientation dependence.
Airport Service Quality Dimensions and its Influence on Airline Passengers’ Satisfaction in India

This paper is aiming at the refinement of Airport Service Quality (ASQ) dimensions based on passengers’ experience. This new ASQ dimensions evolved are in contrast with the conventional method of setting apart areas concerning ASQ as recognized at every interaction points in the functional flow of passengers through various agencies in the airport. The new dimensions arrived in this study were obtained by analyzing the data regarding airport service quality attributes identified and surveyed with the support of instruments developed by Airports Council International (ACI) and are commonly used by airports in India. This study further analyzed and factorized those items into meaningful ASQ dimensions from passengers’ perspective using exploratory factor analysis method and then confirmed the measurement model using confirmatory factor analysis. This study also attempts to find out the relationship between these core dimensional factors of airport service quality and its influence on overall satisfaction of passengers. The interrelationship between these ASQ factors and overall satisfaction level of passengers were estimated using structural equation modeling. The strength of each factor dimension was plotted and drawn implications for the airport operators.
Surfactants with Natural Hydrophobic Tails Polyoxyethylenated Cholesterol-Surface Tension and CMC

Eleven polyoxyethylenated cholesterol nonionics, having different oxyethylene contents, were prepared and their critical micelle concentration (cmc) values were determined in aqueous solutions at 28, 38, 48 and 58C, using the Spinning Drop technique. Surface tension (~)log concentration (c ) isotherms were constructed and values of cmc and cmc were determined through the least squares regression analysis. Some equations relating the obtained cmc values with the number (n) of oxyethlene (EO) units condensed per cholesterol molecule were developed. The developed equations revealed that the cmc values, of this group of nonionic surfactants, decrease with increasing n and temperature. Over the investigated temperature range, less decrease in cmc per oxyethylene unit was achieved at 58C if compared with the sharp decrease obtained at 28-48C. More linearized relations were noticed in Ln cmc%EO plots. Also, the surface tension at cmc, ~cmc, of the investigated nonionics, decreases with increasing n and temperature.
Inherited and Somatic Genetic factors in Colorectal Cancer Development

ABSTRACT Colorectal cancer (CRC) is the 3rd most common cancer and the 4th highest cause of cancer deaths in the world. Genetic factors play a major role in its predisposition, initiation and development. Inherited variants in the CASP8 gene, a key regulator of apoptosis, have a potential yet controversial association with CRC risk. Sporadic CRC develop through different molecular pathways of genomic instabilities and mutations in key cancer driver genes. Classification of sporadic CRC into these molecular pathways has potential implications for diagnosis and treatment and it is an integral part of CRC studies, however, current published research suffers from lack of standardisation. Chromosomal Instability (CIN) drives CRC by affecting cancer driver genes, many of which are still to be identified. This project aimed to: (a) further investigate the role of CASP8 inherited variants in CRC risk, (b) to molecularly classify sporadic CRC tumour DNA samples using standard techniques and definitions, and (c) to identify novel CRC driver genes affected by CIN. A CASP8 promoter in/del variant was genotyped in 1193 CRC cases and 1388 matching controls. The coding region of the CASP8 gene was sequenced in 94 CRC cases to identify potential novel variants and a copy number variant was also investigated. A cohort of 53 paired CRC tumour and normal DNA samples were molecularly classified using standard techniques and definitions. Common aberration analysis was performed on high resolution array comparative genome hybridisation data from 45 chromosomally unstable CRC cases to identify focal minimal common regions (FMCR). CASP8 inherited variants did not significantly affect CRC risk in the investigated cohort. CRC molecular classification confirmed the heterogeneity of sporadic CRC vii and a novel molecular subtype was proposed. FMCR were shown to target cancer related genes and novel CRC driver genes were proposed. Finally, preliminary studies supported the tumour suppressor role of NFKBIA, one of the novel candidate driver genes affected by a deletion FMCR.
Transformational Leadership, Mediating Effect Of Knowledge Management System And Moderating Effect Of Training In Human Capital Development: SEM-SMART PLS Approach

This is a knowledge-based economy era; consequently, the role of human capital cannot be neglected, constituting as it does an important competitive asset in today's global market. After leisure tourism and health tourism, the newest growth sector is education tourism, which attracts a huge number of international students. In the ASEAN region, Singapore and Malaysia are leading countries in this new growth industry. Education tourism is also recognized as a source of GDP growth. To compete with 21st century educational and technological challenges, the government of Thailand has to focus upon improving teachers’ knowledge, skills, and abilities. Human capital can play a vital role in achieving this objective; in turn, this research has developed a framework which identifies the mediating effects of knowledge management systems and the moderating effects of training in developing human capital. Quantitative methods have been used in this study, with data collected from different schools located in Bangkok and other provinces. In order to test the structural model, SMART PLS software has been used in this study. The results of this study reveal that knowledge management systems mediate the relationship between transformational leadership and human capital development. Results also evidence that variable training moderates the relationship between 360 degrees perforce appraisal and human capital development. This study, therefore, contributes to transformational leadership and human capital theory.
Hawkes binomial topic model with applications to coupled conflict-Twitter data

We consider the problem of modeling and clustering heterogeneous event data arising from coupled conﬂict event and social media data sets. In this setting conﬂict events trigger responses on social media, and, at the same time, signals of grievance detected in social media may serve as leading indicators for subsequent conﬂict events. For this purpose we introduce the Hawkes Binomial Topic Model (HBTM) where marks, Tweets and conﬂict event descriptions are represented as bags of words following a Binomial distribution. When viewed as a branching process, the daughter event bag of words is generated by randomly turning on/off parent words through independent Bernoulli random variables. We then use expectation–maximization to estimate the model parameters and branching structure of the process. The inferred branching structure is then used for topic cascade detection, short-term forecasting, and investigating the causal dependence of grievance on social media and conﬂict events in recent elections in Nigeria and Kenya.
What works to prevent violence against women and girls evidence reviews

18/2/166. Wilkinson, D. , Bearup, L. , Soprach, T. 2005. Youth gang rape in Phnom Penh. In S.J. Jejeebhoy, I. Shah, and S. Thapa, eds. Sex without consent: Young people in developing countries. New York: Zed Books. Wood, K. 2005. Contextualizing group rape in post-apartheid South Africa. Culture, health and sexuality, 7(4), 303–317. World Health Organization. 2002. World report on violence and health. Geneva: WHO. World Health Organization, London School of Hygeine and Tropical Medicine. 2010. Preventing intimate partner and sexual violence against women. Geneva: WHO. World Health Organization. 2013. Global and regional estimates of violence against women: prevalence and health effects of intimate partner violence and non-partner sexual violence. Geneva: WHO.
Functional analysis of the OA associated variant rs143383

i Dedication ii Acknowledgements ii Abbreviations ix Chapter 1 General Introduction 1.1 Arthritis 1 1.1.1 Osteoarthritis and its Prevalence 1 1.1.2 Defining OA 2 1.1.3 OA Treatment 3 1.2 Joint Structure and Function 5 1.2. 1 Articular Cartilage 6 1.2. 2 Subchondral Bone 8 1.2. 3 The Joint Capsule and the Synovial Membrane 9 1.3 Joint Homeostasis 9 1.4 Development of the Joint 10 1.5 Pathology of OA 12 1.5. 1 Articular Cartilage 13 1.5. 2 Subchondral Bone 14 1.5. 3 Synovium 15 1.5. 4 Other tissues of the Joint 16 1.6 Risk Factors for OA 16 1.7 Genetics of OA 18 1.7. 1 Family Aggregation Studies 18 1.7. 2 Twin Studies 19 1.7. 3 Candidate Gene Studies 20 1.7. 4 Linkage Studies 21 1.7. 5 Genome Wide Association Scans 23 1.8 Bone Morphogenetic Proteins 25 1.8. 1 BMP Signalling 25 1.8. 2 BMP Inhibitors 26 1.9 GDF5 27 1.9. 1 Examination of the GDF5 gene 28
CHANGES IN TITLE 1) MANAGEMENT OF FRACTURED CENTRAL INCISORS WITH OPEN APEX UNDERGOING ORTHODONTIC TREATMENT FOR THE APICAL BARRIER FORM CALCIUM HYDROXIDE

Dental injury to immature permanent incisors is the commonly encountered problem in young children during the turbulent years of transition into adolescence. The management of such teeth is complicated due to the has to be postponed till an apical ‘stop’ or hard tissue barrier is formed for condensation of gutta percha. This article presented two cases of fractured immature permanent inciso treated successfully with calcium hydroxide to induce apical hard tissue bridge formation.
Groundwater Levels in a Drained Beach in Long and Short Waves Conditions

Drainage of beaches is thought to be a soft engineering solution to counteract erosion. The present work aims to show the response of the groundwater table level when it is influenced by a drain inside the sand, in the vicinity of the shoreline. The knowledge of the water table dynamics helps to identify the role played by the drain, and consequently it is useful to address its function on the overall BDS functioning. The water table dynamics has been mathematically investigated, in presence of both long and short waves. An analytical solution for the Boussinesq equation with long waves and a drainage boundary condition within the porous medium is presented. A VOF numerical tool has been used to study the groundwater table fluctuations driven by the short waves swash. A comparison between the analytical solution and the numerical results in terms of groundwater level has been carried out. The numerical model reproduces the drain-induced dynamics inside the beach. The analytical model, on the other hand, although it is developed under the long wave hypothesis, seems to catch, at least qualitatively, the water table evolution in case of short period regular waves. It enables to think of it as a preliminary evaluation tool for the BDS design.
Energy intake, energy expenditure and BMI of 1st year medical and paramedical students

Introduction: Medical and paramedical students are the backbone of health sector. They generally skip the meals due to their hectic schedule. So the aim of present study was to examine the Energy Intake (i.e. calorie intake), Energy Expenditure (i.e. REE) and BMI of 1 Year Medical and Paramedical Students. Methods: 80 medical and 80 paramedical students were assessed for BMI, CI and REE. BMI was calculated using the measurements of height and weight. Calorie intake was assessed with the help of modified food frequency questionnaire (FFQ) and resting energy expenditure (REE) was obtained using indirect calorimetry. Results: Mean ages of participants under the medical and paramedical groups were 19.9±2.11 and 19.72±1.46 years respectively. Age and height of the participants from both the groups were not significantly different, but a significant difference existed in weight of them. Participants from both the groups were falling under the normal category of BMI, but still a significant difference existed in the BMI of 2groups. Similarly, per day calorie intake of both groups was not significantly different, but there was a significant difference in resting energy expenditure (kcal/day) in both the groups. Conclusion: Though the calorie intake was almost similar in the medical and paramedical students, BMI and REE were found to be higher in medical students than in paramedical students. Reason behind it may be that the medical students have a busier schedule or more of a sedentary lifestyle than the paramedical students.
Influences of Economic Theories on Accounting Theory: the case of the Objective Function of the Firm

This essay aims to establish the relationship between the theoretical precepts that guide the accounting disclosure procedures for its stakeholders, both internal and external, and the two main theoretical trends that address the firm’s objective function: the Shareholder theory and the Stakeholder theory. In the perspective of the Shareholder theory, the firm has to define a single objective, which is to maximize shareholder wealth. In the context of Stakeholders theory, the firm must establish a multiple objective, which is to meet the interests of all those involved with its activities. We discuss to what extent theories, standards and accounting practices emanate from the concepts of the two models, especially regarding the users’ demand for useful and relevant information. There is a predominance of Shareholder theory in influencing accounting principles that guide the disclosure of information, although different accounting reports are already discussed and presented, oriented to the Stakeholders of the firm, without establishing a set of concepts that explain and justify them within the scope of Accounting theory. Additionally, it is argued that, all things taken into consideration, both currents of the Economic theory point in the same direction: to seek the wellbeing of the firm’s stakeholders. The research contributes to the accounting literature, in the sense of clarifying the impacts arising from the two economic models that deal with the objective function of the firm in the evolution of Accounting theory, not yet captured directly in the discussion of the fundamentals of accounting theory.
The effect of functional movement screen and lower extremity training on hamstring/quadriceps ratio in football players

Purpose: The aim of this study is to determine the effect of functional movement screen and lower extremity training on hamstring/quadriceps (H/Q) ratio in football players. Material: 11 players from Sivas Belediyespor, affiliated to the Turkish Football Federation, participated in this study. The average age of the players involved in the study was 25.75±4.45, height averages 178.49±8.72 cm, and body weight averages 69.83±6.47 kg. Players who participated in the study had previously suffered a knee area injury. In addition to team training for 8 weeks, extra exercises to strengthen their hamstring and quadriceps muscles were conducted 3 times a week. Isokinetic force tests and Functional Movement Screen (FMS) tests were conducted in the study. Data obtained were evaluated in SPSS package 24 program. Results: There was a significant difference in the total score of FMS at the level of p<0.05. Deep squat 13.5%, hurdle step 10.49%, in line lunge 9%, shoulder mobility 3.44%, active straight 6.84%, trunk stability push up 6.84%, rotatuar stability 14.73% and FMS total score 17.24% showed improvement. There was a significant difference in the H/Q ratio between both the right knee and left knee pre-test and post-test at p<0.01 level. The right knee developed at a rate of 600 H/Q at a rate of 17.24% and the left knee developed at a rate of 600 H/Q. Conclusions: As a result, 8 weeks of extra lower extremity exercises can be said to increase the H/Q ratio of football players. It is also seen that the FMS score has increased. Thus, it is thought that the risk of football players having a sports injury again is reduced.