Miracle-dz/UniFAR-FTUs huggingface dataset:
The Feasibility Of Malang City As College Town

This literature research aims to determine the condition of Malang city as a city of higher education in Indonesia. Higher education is the main driving force for the development of property, land, and buildings as well as the growth of commercial areas, and is in a good spot for collaborating with communities in dealing with urban problems. The development of higher education in Malang city has improved because many students are interested in continuing their studies in this city. The increase in the number of students reaches 10% per year; this is due to the qualit y of public and private tertiary institutions, the availability of various types of study programs, high and fast access (from Jakarta, Surabaya, and other cities in eastern Indonesia), comfort, safety, and relatively low cost of living compared to other large cities. Malang has 62 colleges with 300,000 students from various places; this brings changes in the physical environment, socio-culture, and economy in Malang. The results of the analysis indicate that Malang City has met the college town criteria, and this will be used as part of research studentification in Malang. This research is intended to confirm the capability of Malang as a city of higher education, referring to the college town characteristics in the related literature, as well as the use of SW OT analysis to identify the potential and obstacles encountered by Malang city as a college town. Index Terms : college towns, neighborhood change, social changes, student, studentification, urban, university. ——————————  ——————————
Bioremediation of Wastewater Stream from Syngas Cleaning Via Wet Scrubbing

Biomass gasification is a process known for its high potential in enabling the exploitation of residual biomass in the production of renewable electricity. At present one of the most favorable patterns from both an environmental and a sustainability point of view is air gasification coupled with an Internal Combustion Engine (ICE) for decentralized production. In order to have the best performances of the ICE to be run with the produced gas, the required technical specifications on gas purity can be achieved at an appropriate level by means of wet scrubbing. In wet gas cleaning approach, stages based on organic liquids (e.g. biodiesel) and water can be jointly adopted for the removal of contaminants. In the present work preliminary results for the regeneration of the wastewater stream produced at a gasification plant whose gas cleaning is carried out with a purification train based on biodiesel and water scrubbing are presented. To this aim three different fungal strains were selected and tested for their bioremediation potential, i.e. Bjerkandera adusta, Arthrinium sp, and Pleurotus ostreatus. Laboratory tests gave an overall positive response on the effectiveness of wastewater treatment by Bjerkandera adusta and Arthrinium sp. thus demonstrating that these microorganisms are able to metabolize, and therefore remove, both aromatic molecules typical of tar produced in gasification processes, and esters of fatty acids constituting the biodiesel used for gas washing in the first stage.
Proteomics Reveal Enhanced Oxidative Stress Responses and Metabolic Adaptation in Acidithiobacillus ferrooxidans Biofilm Cells on Pyrite

Reactive oxygen species (ROS) cause oxidative stress and growth inhibition by inactivation of essential enzymes, DNA and lipid damage in microbial cells. Acid mine drainage (AMD) ecosystems are characterized by low pH values, enhanced levels of metal ions and low species abundance. Furthermore, metal sulfides, such as pyrite and chalcopyrite, generate extracellular ROS upon exposure to acidic water. Consequently, oxidative stress management is especially important in acidophilic leaching microorganisms present in industrial biomining operations, especially when forming biofilms on metal sulfides. Several adaptive mechanisms have been described, but the molecular repertoire of responses upon exposure to pyrite and the presence of ROS are not thoroughly understood in acidophiles. In this study the impact of the addition of H2O2 on iron oxidation activity in Acidithiobacillus ferrooxidans DSM 14882T was investigated. Iron(II)- or sulfur-grown cells showed a higher sensitivity toward H2O2 than pyrite-grown ones. In order to elucidate which molecular responses may be involved, we used shot-gun proteomics and compared proteomes of cells grown with iron(II)-ions against biofilm cells, grown for 5 days in presence of pyrite as sole energy source. In total 1157 proteins were identified. 213 and 207 ones were found to have increased levels in iron(II) ion-grown or pyrite-biofilm cells, respectively. Proteins associated with inorganic sulfur compound (ISC) oxidation were among the latter. In total, 80 proteins involved in ROS degradation, thiol redox regulation, macromolecule repair mechanisms, biosynthesis of antioxidants, as well as metal and oxygen homeostasis were found. 42 of these proteins had no significant changes in abundance, while 30 proteins had increased levels in pyrite-biofilm cells. New insights in ROS mitigation strategies, such as importance of globins for oxygen homeostasis and prevention of unspecific reactions of free oxygen that generate ROS are presented for A. ferrooxidans biofilm cells. Furthermore, proteomic analyses provide insights in adaptations of carbon fixation and oxidative phosphorylation pathways under these two growth conditions.
Fungal Community Structural and Microbial Functional Pattern Changes After Soil Amendments by Oilseed Meals of Jatropha curcas and Camelina sativa: A Microcosm Study

The meals after oil extraction from many oilseed crops have nutrition and biofumigation potential for land application. Oilseed meal (SM) from the dedicated bioenergy crop Jatropha curcas were implicated to contain compounds that have antibacterial properties on some soil pathogens. However, little is known about its effect on non-targeted soil microbial community, especially on fungi. SM from Camelina sativa contains moderate level of glucosinolates (GLS) and was under studied. To investigate soil fungal community responses to jatropha and camelina SMs, we conducted a lab based microcosm study, amending soil with 1% SMs of jatropha, camelina, flax, and biomass of wheat straw. Fungal community abundance and structure were analyzed based on the ITS region using qPCR and tag-pyrosequencing. Microbial functional changes were examined by community level physiological profile (CLPP) using Biolog assay. Both SMs from jatropha and camelina showed biofumigant properties and inhibited fungal proliferation. Jatropha SM significantly altered soil fungal community structures with lower fungal biodiversity and higher Chaetomium composition. Camelina SM amended soil promoted Fusarium proliferation. CLPP indicated sequential hierarchy for C metabolism in the oilseed-amended microcosms was generally complex C > phosphate-associated C > carboxylic acids > carbohydrates > amines > amino acids. No significant difference in CLPP was detected due to the type of SM treatment. Our data indicate that both SMs of jatropha and camelina have biofumigant properties and can differentially impact soil microbial communities, and the changes were relatively persistent over time. Microbial functional patterns on the other side were not impacted by SM type. Our study revealed biofumigant and nutritional influence of SMs from dedicated biofuel plants on soil microbial community. This information will help properly using jatropha and camelina SMs for pathogen control while minimizing their negative impacts on non-target microorganisms. However, further studies in the field are demanded to investigate their influences in real practice.
Psychometric properties of the workplace psychologically violent behaviors-WPVB instrument. Translation and validation in Greek Health Professionals

Background Mobbing exerts severe psychological and occupational effects on the victim. This study aims to validate the Yildirim & Yildirim's Workplace Psychologically Violent Behaviors (WPVB) instrument (2008) in the Greek language in Greece, as cultural variations may result in significantly different perceptions of mobbing. Methodology A translation process of the WPVB questionnaire scale was followed from the English to the Greek version and a review by a team of experts for its content validity took place, as well. Principal component analysis took place and the Cronbach's index was 0.95. The cross sectional, quantitative study was performed in 1536 health professionals (HPs), working in 11 public hospitals for at least one year with response rate of 76.8%. Results Factor analysis revealed two factors, and 31-item construct, compared to the four factors and the 33-item construct of the original version of the tool. All items were found to have a statistically significant correlation (p < 0.001). Median score was 0.48. Whereas 25% of answers score was above 1.00, thus suggesting significant mobbing in around 25% of HPs. Association of WPVBs subscales with sex and occupation are had lower values in women as compared to men. Lower scores on “Attack on personality” and “Total mobbing” score were recorded in nurses as compared to doctors. Doctors had lower scores on “Individual's isolation from work” as compared to administrative personnel, while had greater scores on “Individual's isolation from work” as compared to technicians. Nurses had significantly lower scores on “Attack on professional status”, “Individual's isolation from work”, “Direct attack” and “Total mobbing” score as compared to administrative personnel. Conclusions The study highlights that the phenomenon of mobbing exists in Greek HPs regardless of age, gender, level of study and negatively affects their lives. Focusing on improving this area, is expected to promote occupational health and safety of these workers.
Tensor-valued diffusion encoding for diffusional variance decomposition (DIVIDE): Technical feasibility in clinical MRI systems

Microstructure imaging techniques based on tensor-valued diffusion encoding have gained popularity within the MRI research community. Unlike conventional diffusion encoding—applied along a single direction in each shot—tensor-valued encoding employs diffusion encoding along multiple directions within a single preparation of the signal. The benefit is that such encoding may probe tissue features that are not accessible by conventional encoding. For example, diffusional variance decomposition (DIVIDE) takes advantage of tensor-valued encoding to probe microscopic diffusion anisotropy independent of orientation coherence. The drawback is that tensor-valued encoding generally requires gradient waveforms that are more demanding on hardware; it has therefore been used primarily in MRI systems with relatively high performance. The purpose of this work was to explore tensor-valued diffusion encoding on clinical MRI systems with varying performance to test its technical feasibility within the context of DIVIDE. We performed whole-brain imaging with linear and spherical b-tensor encoding at field strengths between 1.5 and 7 T, and at maximal gradient amplitudes between 45 and 80 mT/m. Asymmetric gradient waveforms were optimized numerically to yield b-values up to 2 ms/μm2. Technical feasibility was assessed in terms of the repeatability, SNR, and quality of DIVIDE parameter maps. Variable system performance resulted in echo times between 83 to 115 ms and total acquisition times of 6 to 9 minutes when using 80 signal samples and resolution 2×2×4 mm3. As expected, the repeatability, signal-to-noise ratio and parameter map quality depended on hardware performance. We conclude that tensor-valued encoding is feasible for a wide range of MRI systems—even at 1.5 T with maximal gradient waveform amplitudes of 33 mT/m—and baseline experimental design and quality parameters for all included configurations. This demonstrates that tissue features, beyond those accessible by conventional diffusion encoding, can be explored on a wide range of MRI systems.
The kisspeptin analog C6 is a possible alternative to PMSG (pregnant mare serum gonadotropin) for triggering synchronized and fertile ovulations in the Alpine goat

In temperate regions goat’s reproduction is seasonal. To obtain year-round breeding, hormonal treatments are currently applied. These treatments usually combine a progesterone analog with the pregnant mare serum gonadotropin (PMSG). However, their use has significant ethical and environmental drawbacks. Therefore, alternative methods to manage reproduction are needed. The discovery that in mammals the neuropeptide kisspeptin is a major positive regulator of hypothalamo-pituitary gonadal axis offered an attractive alternative strategy to control reproduction. We have previously designed a kisspeptin analog, called C6, which offers pharmacological advantages over endogenous kisspeptin. These include a longer lasting effect and enhanced activity following intramuscular injection. In the present work, we evaluated C6 effect on LH and FSH plasma concentrations in the Alpine goat breed and tested whether C6 could replace PMSG to trigger ovulation. An intramuscular injection of C6 (15 nmol/doe) given 24 hours after the end of progestogen treatment induced a surge-like peak of both LH and FSH. This was followed by an increase of progesterone, a hallmark of ovulation induction and corpus luteus formation. These results were obtained at three different time of the year: during the breeding season, the non-breeding season and at the onset of the breeding season. Furthermore, we compared the efficacy of C6 and PMSG to induce fertile ovulations when these treatments are given at the onset of the breeding season and are followed by artificial insemination. The results of this first attempt were extremely promising with gestation rates of 45% and 64% for C6 and PMSG respectively. Pending optimization of the treatment procedure in order to improve efficacy, kisspeptin analogs could be the long sought-after alternative to PMSG.
The birch GLK1 transcription factor mutant reveals new insights in chlorophyll biosynthesis and chloroplast development.

Birch (Betula platyphylla × B. pendula) is a precious material for landscaping due to its attractive white bark and straight trunk. In this study, we characterized a T-DNA caused yellow-green leaf mutant yl in birch. We identified six insertion sites (ISs) in yl mutant by genome resequencing and found a 40-kb deletion containing BpGLK1 around IS2 on chromosome 2. Complementation experiment of yl mutant and repression of BpGLK1 in wild type birch confirmed that BpGLK1 gene was responsible for the mutated phenotype of yl. Physiological and ultrastructural analysis showed that the leaves of yl mutant and BpGLK1 repression lines had decreased chlorophyll content and defective chloroplast development compared to the wild type. Furthermore, the loss function of BpGLK1 also affected photosynthesis in leaves. Transcriptomics, proteomics and ChIP-PCR results revealed that BpGLK1 directly interacted with the promoter of genes related to antenna protein, chlorophyll biosynthesis, photosystem subunit synthesis and regulated their expression. Collectively, our research not only provided a new insight into the mechanism of chloroplast development and chlorophyll biosynthesis regulated by BpGLK1, but also provided new transgenic birch varieties with various levels of yellowing leaves by repressing BpGLK1 gene expression.
Melatonin Protects MCAO-Induced Neuronal Loss via NR2A Mediated Prosurvival Pathways

Stroke is the significant cause of human mortality and sufferings depending upon race and demographic location. Melatonin is a potent antioxidant that exerts protective effects in differential experimental stroke models. Several mechanisms have been previously suggested for the neuroprotective effects of melatonin in ischemic brain injury. The aim of this study is to investigate whether melatonin treatment affects the glutamate N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor signaling in cerebral cortex and striatum 24 h after permanent middle cerebral artery occlusion (MCAO). Melatonin (5 mg/kg) attenuated ischemia-induced down regulation of NMDA receptor 2 (NR2a), postsynaptic density-95 (PSD95) and increases NR2a/PSD95 complex association, which further activates the pro-survival PI3K/Akt/GSK3β pathway with mitigated collapsin response mediator protein 2 (CRMP2) phosphorylation. Furthermore, melatonin increases the expression of γ-enolase, a neurotrophic factor in ischemic cortex and striatum, and preserve the expression of presynaptic (synaptophysin and SNAP25) and postsynaptic (p-GluR1845) protein. Our study demonstrated a novel neuroprotective mechanism for melatonin in ischemic brain injury which could be a promising neuroprotective agent for the treatment of ischemic stroke.
Effectiveness and safety of warm needle acupuncture on children with cerebral palsy

Background: Warm needle acupuncture (WNA) is an integral part of the acupuncture therapy, which combines acupuncture and moxibustion. Children with cerebral palsy (CP) is a common disease in children, which seriously affects children's growing development, physical and mental health. The clinical practice indicates that WNA has a therapeutic effect on children with CP. Here we will provide a protocol to explore the effectiveness and safety of WNA for children with CP. Methods: We will search the randomized controlled trails (RCT) literatures of WNA for children with CP in 5 English databases [PubMed, Web of Science, EMBASE, the Cochrane Central Register of Controlled Trials (Cochrane Library), and WHO International Clinical Trials Registry Platform (ICTRP)] and 4 Chinese databases [Chinese National Knowledge Infrastructure (CNKI), Chinese VIP Information, Wanfang Database, and Chinese Biomedical Literature Database (CBM)]. Activity of Daily Living Scales (ADL) of the patient will be considered as the primary outcome and the secondary outcome will include 88 items of gross motor function scale (GMFM-88), Gesell Growth Table (GGT), Criteria for judging efficacy and adverse events caused by WNA such as dizziness, nausea, vomiting, weariness, etc. The selection of the studies will be performed by EndnoteX7 software. And we will conduct all analyses with RevMan software V5.3. Result: This study will provide a rational synthesis of current evidences for WNA on children with CP. Conclusion: The conclusion of this study will provide evidence to judge the effectiveness and safety of WNA on children with CP. Registration PROS-PERO CRD42019122034
Improvements in episodic future thinking methodology: Establishing a standardized episodic thinking control

Objective Delay discounting (DD) is the choice of a smaller immediate reward over a larger delayed reward, which has been associated with a number of maladaptive behaviors. Episodic future thinking (EFT), the ability to project oneself into the future, is an intervention designed to reduce DD. EFT has reliable effects on DD, but the size of the effect varies, which could be due in part to the use of different control groups. Episodic recent thinking (ERT) serves as a common control for many EFT studies, but the temporal window of “recent” cues ranges from 24 hours ago to 12 days past. Since prior research has shown that retrospection can lead to prospection, it may be important to ensure that EFT controls do not inadvertently lead to prospection for some participants thereby increasing the variability of the control condition. The present study sought to develop a comparison group that standardizes the time frame and experiences that are the basis for the recent thinking control. Methods Participants (n = 53, 18–45) were randomized to one of three conditions: EFT, ERT, or standardized episodic thinking (SET). Participants attended a laboratory appointment where they played mobile application games, created cues, and completed a DD task. Results There was a significant difference between groups (p<0.05), with EFT reducing discounting more than either control (p<0.05), and no differences between ERT and SET (p>0.05). Conclusion This study established that SET provides an alternative control in EFT studies and provides the advantage of standardizing the participant’s recent experience without changing the relationship between EFT and recent thinking controls.
Psychological and Psychosomatic Symptoms of Second Victims of Adverse Events: a Systematic Review and Meta-Analysis

Supplemental digital content is available in the text. Objectives Despite growing interest in the second-victim phenomenon and greater awareness of its consequences, there has not been a meta-analysis quantifying the negative impact of adverse events on providers involved in adverse events. This study systematically reviewed the types and prevalence of psychological and psychosomatic symptoms among second victims. Methods We conducted a systematic review of nine electronic databases up to February 2017, without restrictions to publication date or language, examining also additional sources (e.g., gray literature, volumes of journals). Two reviewers performed the search, selection process, quality assessment, data extraction, and synthesis. We resolved disagreements by consensus and/or involving a third reviewer. Quantitative studies on the prevalence of psychological and psychosomatic symptoms of second victims were eligible for inclusion. We used random effects modeling to calculate the overall prevalence rates and the I2 statistic. Results Of 7210 records retrieved, 98 potentially relevant studies were identified. Full-text evaluation led to a final selection of 18 studies, based on the reports of 11,649 healthcare providers involved in adverse events. The most prevalent symptoms were troubling memories (81%, 95% confidence interval [CI] = 46–95), anxiety/concern (76%, 95% CI = 33–95), anger toward themselves (75%, 95% CI = 59–86), regret/remorse (72%, 95% CI = 62–81), distress (70%, 95% CI = 60–79), fear of future errors (56%, 95% CI = 34–75), embarrassment (52%, 95% CI = 31–72), guilt (51%, 95% CI = 41–62), and sleeping difficulties (35%, 95% CI = 22–51). Conclusions Second victims report a high prevalence and wide range of psychological symptoms. More than two-thirds of providers reported troubling memories, anxiety, anger, remorse, and distress. Preventive and therapeutic programs should aim to decrease second victims’ emotional distress.
Camouflage treatment for skeletal Class III patient with facial asymmetry using customized bracket based on CAD/CAM virtual orthodontic system: A case report.

When considering camouflage orthodontic treatment for Class III malocclusion with skeletal facial asymmetry, it is crucial to preserve the favorable compensated posterior occlusion. Once the inclination of the compensated occlusion is changed during orthodontic treatment, unstable occlusion, such as crossbite or scissor bite may occur. A 23-year-old female patient had anterior spacing with Class III malocclusion and a mandibular asymmetry. A nonsurgical approach was adopted. The treatment objectives were to establish a Class I molar relationship with compensated inclination of the posterior dentition and to correct the midline deviation. To achieve these goals, the computer-aided design/computer-aided manufacturing (CAD/CAM) orthodontic system plus customized brackets was applied, and miniscrews were used to distalize the left mandibular dentition for midline correction. The results suggested that the CAD/CAM-based customized brackets can be efficiently used in camouflage treatment to achieve a correct final occlusion.