Miracle-dz/UniFAR-FTUs huggingface dataset:
Chromatin-regulating genes are associated with postoperative prognosis and isocitrate dehydrogenase mutation in astrocytoma

Background Abnormality in chromatin regulation is a major determinant in the progression of multiple neoplasms. Astrocytoma is a malignant histologic morphology of glioma that is commonly accompanied by chromatin dysregulation. However, the systemic interpretation of the expression characteristics of chromatin-regulating genes in astrocytoma is unclear. Methods In this study, we investigated the expression profile of chromatin regulation genes in 194 astrocytoma patients sourced from The Cancer Genome Atlas (TCGA) database. The relevance of gene expression and postoperative survival outcomes was assessed. Results Based on the expression patterns of chromatin regulation genes, two primary clusters and three subclusters with significantly different survival outcomes were identified. The patients in cluster_1 (or subcluster_1) had a poorer prognosis than the other groups, and this particular cohort were older, with a more advanced grade of tumor and isocitrate dehydrogenase-wildtype distribution. Detection of the differentially expressed genes revealed that the group with poor prognosis was characterized by downregulation of H2AFY2, WAC, HDAC5, ZMYND11, TET1, SATB1, and MYST4, and overexpression of EYA4. Moreover, all eight genes were significantly correlated with overall survival (OS) in astrocytoma. Age-associated genes were investigated and the expression levels of EYA4, TET1, SATB1, WAC, ZMYND11, and H2AFY2 were found to be closely correlated with advanced age. Regression analysis suggested that the expression levels of H2AFY2, HILS1, EYA1, EYA4, and KDM5B were independently associated with IDH mutation status. The differential expressions of 34 common genes were significantly associated with age, grade, and IDH mutant. Conclusions The study revealed that the expression pattern of chromatin regulation genes was significantly associated with postoperative prognosis in astrocytoma. Moreover, the differential expression of particular genes was strongly associated with clinical characteristics such as age, grade, and IDH subtype. These results suggest that the genes involved in chromatin regulation play important roles in the biological process of astrocytoma progression, and these molecules could potentially serve as therapeutic targets in astrocytoma.
Gaussian functions in Hylleraas‐configuration‐interaction calculations. VI. The first excited state of H+3

The Hylleraas‐configuration‐interaction (H‐CI) method has been applied to the first 3Σ+u excited state of the H+3 molecular ion. Besides the ground state, this is the only known bound state of H+3, albeit with a very weak minimum of 8.428 kcal/mol. The equilibrium geometry and the minimum energy have been determined. The Hylleraas‐CI energy of −1.116 102 7 a.u. at an equidistant nuclear separation of 2.454 bohr is the lowest reported so far. The vibrational force constants and vibrational frequencies also have been computed.
Protea Nutritional Problems and Soil Nutrient Status in Norton-Darwendale and Juliasdale Farming Areas, Zimbabwe

ABSTRACT A study was conducted from November 2000 to February 2001 to establish causes of poor protea plant growth in the Juliasdale and Norton-Darwendale commercial farming areas of Zimbabwe. Soil and leaf samples from farmer-perceived “deficient” and “normal” areas were analyzed. Soils perceived by farmers to be deficient had lower levels of phosphorus (P), potassium (K), calcium (Ca), and magnesium (Mg) compared with the normal soils. In Juliasdale, all cultivars from perceived-deficient samples had lower levels of zinc (Zn) in leaves compared with normal leaves. Leucospermum cultivar ‘Tango’ and Protea cultivar ‘Moonshine’ also had low levels of P and Zn in the deficient plants compared with the normal plants. In Norton-Darwendale, the Protea cultivar ‘Moonshine’ had lower levels of nitrogen (N), P, K, and boron (B) in perceived-deficient samples compared with normal samples. Soil-analysis data were generally comparable to leaf-analysis data, indicating the potential use of leaf analysis to determine nutritional requirements of proteas.
Selective Intermolecular Carbon-Hydrogen Bond Activation by Synthetic Metal Complexes in Homogeneous Solution

One {open_quotes}Holy Grail{close_quotes} of C-H activation research, therefore, is not simply to find new C-H activation reactions but to obtain an understanding of them that will allow the development of reagents capable of selective transformations of C-H bonds into more reactive functionalized molecules. Although a few interesting organic and main group reagents have been discovered that show intriguing potential for meeting this goal, much of the activity in this field has been in transition metal chemistry. The present Account therefore reflects this emphasis. 109 refs., 3 figs.
Towards understanding crime dynamics in a heterogeneous environment: A mathematical approach

Abstract Crime data provides information on the nature and location of the crime but, in general, does not include information on the number of criminals operating in a region. By contrast, many approaches to crime reduction necessarily involve working with criminals or individuals at risk of engaging in criminal activity and so the dynamics of the criminal population is important. With this in mind, we develop a mechanistic, mathematical model which combines the number of crimes and number of criminals to create a dynamical system. Analysis of the model highlights a threshold for criminal efficiency, below which criminal numbers will settle to an equilibrium level that can be exploited to reduce crime through prevention. This efficiency measure arises from the initiation of new criminals in response to observation of criminal activity; other initiation routes - via opportunism or peer pressure - do not exhibit such thresholds although they do impact on the level of criminal activity observed. We used data from Cape Town, South Africa, to obtain parameter estimates and predicted that the number of criminals in the region is tending towards an equilibrium point but in a heterogeneous manner - a drop in the number of criminals from low crime neighbourhoods is being offset by an increase from high crime neighbourhoods.
Rapid and Accurate Sizing of DNA Fragments by Ion-Pair Chromatography on Alkylated Nonporous Poly(styrene-divinylbenzene) Particles

Ion-pair reversed-phase high-performance liquid chromatography on nonporous alkylated poly(styrene-divinylbenzene) particles allowed the separation of double-stranded DNA fragments in a few minutes with a resolution comparable to that obtained in slab or capillary gel electrophoresis. Using gradients of acetonitrile in 0.1 M triethylammonium acetate, DNA fragments tiering in length only by 2-3% could be resolved. Synthesis of the stationary phase was very reproducible, and equilibration of a freshly packed column for at least 2 h proved to be necessary for optimum column performance, whereas column regeneration for 1-5 min was adequate between gradient runs. Various DNA molecular weight markers ranging from 51 to 2176 base pairs in length were used to study the size dependence of retention. A plot of capacity factors versus logarithm of molecular weights revealed a clear correlation between size and retention. Both a local and a global approximation method, which tiered with regard to the number of known standard fragments used below and above the fragments with unknown length to create a sizing curve based on simplelinear regression, gave essentially identical results, with the inaccuracy of length measurement being 0.05-3.2%. This compares favorably with the accuracy obtained in gel electrophoresis
Efficacy of Autologous Fat Grafting in Restoring Facial Symmetry in Linear Morphea-Associated Lesions

Morphea is a rare sclerotic autoimmune disorder primary affecting the skin and subcutaneous tissues. The linear head variants involve the facial area, with asymmetries and deformities. Eighteen patients with hemifacial deformity (age range 14–75 years) were assessed before surgery (T0), and after one (T1, 18 patients) or two (T2, six patients) surgical treatments of facial autologous fat grafting. A stereophotogrammetric reconstruction of the facial surface was obtained for each patient and a group of control subjects, and facial symmetry was quantified according to the root mean square distance between homologous areas of trigeminal innervation. Values obtained from the control subjects were used to calculate z-scores for patients. At T0, all facial thirds of the patients resulted significantly more asymmetrical than those of the control subjects (Mann–Whitney test, p < 0.05), while at T1, the symmetry of the middle facial third did not differ from that of control subjects (p = 0.263). At T2, the upper and the lower facial thirds also did not differ from the control values (p > 0.05). The faster result obtained in the facial middle third was in accord with clinical findings. In conclusion, autologous fat grafting significantly improved facial asymmetry after one (middle facial third) or two (lower and upper thirds) treatments; the outcomes were efficaciously quantified by stereophotogrammetry.
Scattering of Extremely Low Frequency Electromagnetic Waves by a Localized Seismogenic Ionospheric Perturbation: Observation and Interpretation

A significant anomaly in the extremely low frequency (ELF) spectra of Schumann resonance (SR) was discovered for the 1999 Chi‐Chi earthquake (EQ) in Taiwan as observed in Japan. Similar phenomena were confirmed for other EQs remote from the observer by a few megameters. An additional effect was detected for nearby EQs. The anomalies were explained by ELF radio wave scattering from a seismogenic disturbance. The global thunderstorms serve as the source positioned at the equator, and the localized seismogenic perturbation was placed above the EQ epicenter. We evaluate a seismic impact on SR power spectra using the realistic conductivity profile of atmosphere. The nonuniformity above EQ epicenter is axially symmetric varying along the radius according to Gaussian law whose scale depends on the magnitude. We use the complex characteristic heights relevant to the regular and disturbed cavities. These are substituted into the two‐dimensional telegraph equation (2DTE) for electric and magnetic fields. Deviations from the regular spectra are the seismogenic modifications that depend on the EQ magnitude. Computations indicate that a distant localized seismogenic nonuniformity provides a noticeable impact when the EQ magnitude exceeds the M = 7 threshold. The effect is also modeled of the nearby (up to 500 km) moderate (magnitude 5.5) EQs. The resonance spectra of disturbed fields become elevated as a whole. The distance dependence of field disturbance repeats seismogenic modifications in the characteristic heights above the observer. Model computations are compared with available observations.
A seven-coordinated tin(IV) complex: dichloro­[2,6-diacetyl­pyridine bis­(S-benzyl­dithio­carbazato-κ5S,N,N′,N′′,S′]tin(IV)

The penta­dentate ligand 2,6-diacetypyridine bis­(S-benzyl­dithio­carbazate) reacts with SnCl2·2H2O and atmospheric O2 to form a seven-coordinated SnIV complex. The asymmetric unit of the title compound, [Sn(C25H23N5S4)Cl2], consists of one half-mol­ecule. One Cl, Sn, N of the pyridine ring and the para-C,H atoms lie on a twofold axis. The SnIV ion is seven-coordinated with a distorted penta­dentate bipyramidal geometry. The dithio­carbazate ligand coordinates as a dianionic penta­gonal ligand through the pyridine N atom, the two imine N atoms and the two thio­carbazate S atoms, forming the penta­gonal plane; the two chloride ions are in axial positions. The complex was also characterized by 119Sn Mossbauer and IR spectroscopies.
Comparison between radiotherapy and transoral laser microsurgery treatments in early-stages of glottis cancer: A five-year follow-up study

This study was aimed to compare the recurrence-free survival rate among patients with Stage I or II of squamous carcinoma of the glottis treated with transoral laser microsurgery or radiotherapy, at a Spanish tertiary hospital. Between January 2004 and December 2016, data were collected from 120 patients diagnosed with stages I or II of squamous cell carcinoma of the larynx located in the glottis. Ninety-one patients were treated with transoral laser microsurgery and 29 patients received radiotherapy. The recurrence-free survival was studied during the first five years after the primary treatment. Kaplan-Meier survival curves and Cox regression models were performed. The cumulative incidence of glottis cancer recurrence was 62.6% in those treated with transoral laser microsurgery and 65.5% in those treated with radiotherapy. This led to an absolute risk reduction of 2.9% (95% CI: -17.1 to 22.8), and a number needed to treat of 35 patients. Those patients who received transoral laser microsurgery had a 17% lower risk of recurrence of glottis cancer than those treated with radiotherapy (hazard ratio, HR = 0.83; 95% CI 0.42 to 1.64; Cohen’s d = 0.65). In the initial stages of glottis squamous cell carcinoma, treatment with transoral laser microsurgery shows a tendency for higher re¬currence-free survival than treatment with radical radiotherapy in the first five years of intervention. Patients were not assigned randomly to the treatment, which might influence the generalization of our findings.
Effectiveness and Safety of Non-Vitamin K Antagonist Oral Anticoagulants Compared to Vitamin K Antagonists for the Treatment of Ventricular Thrombus: A Systematic Review and Meta-analysis of Observational Studies

Background To compare the effectiveness and safety of non-vitamin K antagonist oral anticoagulants (NOACs) and vitamin K antagonists (VKAs) on the rate of thrombus resolution and clinical outcomes.Method MEDLINE, PUBMED, EMBASE, Cochrane Library, Web of Science, China National Knowledge Infrastructure Database and Wanfang Database, were searched up to August 16, 2020. Observational studies of patients with ventricular thrombus which compared the effect of two agents on the primary outcome were included. The primary outcome was rate of thrombus resolution, and the secondary outcomes were systemic embolism, bleeding and all-cause death. Odds ratio (OR) and 95% confidential intervals (CI) were utilized for the pooled results.Result Eight studies with 905 participants were finally included. Among these cases, 66.6% of patients received VKAs and 33.4% of patients received NOACs. Rivaroxaban (71.9%) was the most commonly used NOACs. There were no significant differences between NOACs and VKAs groups in thrombus resolution (OR 1.18, 95% CI 0.73-1.91), systemic embolism (OR 0.83, 95% CI 0.34-2.05), bleeding (OR 0.65, 95% CI 0.35-1.19) and all-cause death (OR 0.95, 95% CI 0.53-1.71). In studies with rivaroxaban predominantly or only rivaroxaban in the NOACs groups, NOACs group showed high thrombus resolution rate (OR 2.31, 95% CI 1.31-4.07) and lower systemic embolism rate (OR 0.32, 95% CI 0.11-0.96) than VKAs group, but no differences in bleeding.Conclusion Our findings showed that NOACs had a comparative complete resolution of thrombus compared with VKAs, as well as systemic embolism, bleeding events and all-cause death. In subgroups with rivaroxaban predominantly or only rivaroxaban in the NOACs group, NOACs showed better efficacy and safety profiles than VKAs, indicating that rivaroxaban might have favorable effectiveness over VKAs, though the sample size of NOACs in ventricular thrombus is small and the studies are most non-randomized. Further randomized controlled trials are urgently required to assess the effectiveness and safety of NOACs in patients with ventricular thrombus.
Nonlinear Inferential Parallel Cascade Control

This paper discusses the use of nonlinear inferential parallel cascade control (NIPCC) to improve control system performance. The goal of NIPCC is to detect and compensate for the effects of unmeasured disturbances faster than the feedback control being employed. NIPCC behaves in a manner that is similar to normal cascade control, but NIPCC has a parallel feedback architecture. NIPCC can be thought of as a limiting case of developing a soft sensor, and thus, NIPCC draws from both parallel cascade control and inferential sensing. The effectiveness of NIPCC is demonstrated on the Tennessee Eastman test process. NIPCC holds promise as an effective means of improving plant-wide control.
Turning the gaze to maize: The effects of maize kernels in straw as enrichment on exploration in pigs

Tail biting is one of the biggest problems in pig production systems that causes animal welfare and economic problems. Therefore, tail docking is a widely used intervention to reduce tail biting. However, appropriate enrichment material that stimulates and increases exploration behaviour of pigs also reduces the prevalence and risk of tail biting. In 288 pigs with undocked tails we investigated whether the attractiveness of chopped straw (CS) as enrichment material can be further increased when maize kernels were added (CS+MK). Further, we examined whether a higher attractiveness is accompanied by reduced tail incidents. We used material dispensers equipped with ultra-high-frequency radio-frequency identification (UHF RFID) systems to record individual exploration times of the pigs to the offered enrichment materials. Furthermore, animals were scored thrice for tail length losses and tail injuries, i.e. after the rearing period, in the middle of the fattening period and at the end of the fattening period. Both rearing and fattening pigs had higher exploration durations when housed with CS+MK compared to CS (LME: rearing, P<0.001, fattening, P<0.05). Interestingly, enrichment materials not only remained interesting but were used even more from rearing to fattening. However, when CS+MK was offered pigs showed a higher prevalence for tail biting incidents in the rearing, but not in the fattening period, compared to CS (rearing GLMM, P<0.01). This may have resulted from competition for the more attractive enrichment material (CS+MK). An edible additive increased the interest for straw in pigs over long term but could not improve tail status.
Hot Water Extraction of Brown Seaweed, Nagamo (Sargassum horneri) Processing Residue

Nagamo (Sargassum horneri) processing residue was extracted using a hot water extraction method at various temperatures and solvent/material ratios and analyzed for total sugar (TS). The extraction characteristics of TS were characterized by Peleg’s model, and the optimum extraction conditions for the Nagamo processing residue were obtained at 85°C at a solvent/material ratio of 5. At experimental temperatures and solvent/material ratios, the TS content increased rapidly for the first 2 h and then reached the equilibrium concentration. Additionally, the antioxidant activity (SOD) of the extraction was 60.8% or higher. Thus, it was concluded that the Nagamo processing residue contains biologically active polysaccharides, which can be obtained by using a transportable 400 L-batch extraction process with hot water.
Authentication Utilizing Prior Routing for Versatile Network

In the current circumstance, far off progressions have achieved tremendous reputation. This distant development is used in various applications. In distant advancement, Versatile Specially delegated Organizations (MANETs) are a part and it needn't bother with any pre-set-up establishment. The dynamic character of those associations makes them more utilitarian and it is sensible for certain applications. MANET has high convenience and doesn't rely upon united position. This nature of MANET is weaker against various security attacks and risks. While standing out from the traditional associations, uncommonly named associations are having higher opportunities for some guiding attacks. Ensuring about MANET is a troublesome issue, which need more examination. Lately, different authorities proposed different responses for recognizing the directing attacks in MANET. In this survey, progressing systems and strategies achieved for MANET coordinating attacks is discussed. The overview out and out presents the issues and merits of those current systems.
Detection of Blueberry red ringspot virus in different stages of Parthenolecanium corni in Poland

Detection of Blueberry red ringspot virus in different stages of Parthenolecanium corni in Poland. European fruit lecanium scales (Parthenolecanium corni) appeared in a large mass on highbush blueberry plants in central Poland. Some of the highbush blueberry plants growing in the studied plantation were infected by Blueberry red ringspot virus (BRRSV). Since no insect vector of BRRV is known so far, attempts were made to establish whether the soft scale pests were able to uptake the virus with the sap of the infected plants during feeding. The virus was detected and identified using the PCR and the DNA-DNA dot blot hybridisation technique in almost all the tested larval stages (56/60) and adult females (18/20) of P. corni feeding on BRRSV-infected highbush
The dissolution of carbon nanotubes in aniline, revisitedElectronic Supplementary Information (ESI) available: additional TEM pictures of aniline treated MWNTs and SEM of the PTFE membranes used in the work. See http://www.rsc.org/suppdata/jm/b4/b403509g/

Thorough examination of a previous report on the high solubility of carbon nanotubes in refluxing aniline reveals that the reported optical properties of the “nanotube” solution are due to aniline decomposition products, rather than functionalized nanotubes. No appreciable dissolution of single-wall carbon nanotubes can be achieved by this method, although some solubilization of multiwall nanotubes has been confirmed by SEM and TEM analyses.
Molecular dynamic study of subtilisin Carlsberg in aqueous and nonaqueous solvents

Using molecular dynamics simulations, we have obtained an important insight into the structural and dynamical changes exerted by a nonaqueous solvent on the serine protease subtilisin Carlsberg. Our findings show that the structural properties of the subtilisin–acetonitrile (MeCN) system were sensitive to the amount of water present at the protein surface. A decrease or lack of water promoted the enzyme–MeCN interaction, which increased structural changes of the enzyme primarily at the surface loops. This effect caused variations on the secondary and tertiary structure of the protein and induced the opening of a pathway for the solvent to the protein core. Also, disturbance of the oxyanion hole was observed due to changes in the orientation in the Asn-155 side chain. The disruption of the oxyanion hole and the changes of the tertiary structure should affect the optimal activity of the enzyme.