Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of Altmetrics in Social Recognition of Neurology and Neurological Disorders

This study used Altmetric analysis to rank neurological articles and assessed the implications in relation to the social recognition of neurology and neurological disorders. An Altmetric Explorer search was conducted on 25 May 2018 for articles published in the 91 journals included in the 2015 InCites™ Journal Citation Report®. We identified and analyzed the 100 articles with the highest Altmetric Attention Scores (AASs). A major proportion of the social impact (high AASs) was focused on neurodegenerative disorders such as dementia and neurodegenerative disorders. About half of the high-ranking articles provided academic information such as disease information (29 articles, 29%), new or advanced treatments (17%), and side effects of treatment (8%). The journal with largest number of top 100 articles was the New England Journal of Medicine (29 articles). Some of the data gathered via altmetrics can change a field of study, the public’s health, or a larger society. This is the first report on the impact of academic articles in neurological disorder on the general public living in our altered information society.
Reclassification of prosthesis-patient mismatch after transcatheter aortic valve replacement using predicted vs. measured indexed effective orifice area.

AIMS The objective was to compare the incidence and impact on outcomes of measured (PPMM) vs. predicted (PPMP) prosthesis-patient mismatch following transcatheter aortic valve replacement (TAVR). METHODS AND RESULTS All consecutives patients who underwent TAVR between 2007 and 2018 were included. Effective orifice area (EOA) was measured by Doppler-echocardiography using the continuity equation and predicted according to the normal reference for each model and size of valve. PPM was defined using EOA indexed (EOAi) to body surface area as moderate if ≤0.85 cm2/m2 and severe if ≤ 0.65 cm2/m2 (respectively, ≤ 0.70 and ≤ 0.55 cm2/m2 if body mass index ≥ 30 kg/m2). The outcome endpoints were high residual gradient (≥20 mmHg) and the composite of cardiovascular mortality and hospital readmission for heart failure at 1 year. Overall, 1088 patients underwent a TAVR (55% male, age 79.1 ± 8.4 years, and STS score 6.6 ± 4.7%); balloon-expandable device was used in 83%. Incidence of moderate (10% vs. 27%) and severe (1% vs. 17%) PPM was markedly lower when defined by predicted vs. measured EOAi (P < 0.001). Balloon-expandable device implantation (OR: 1.90, P = 0.029) and valve-in-valve procedure (n = 118; OR: 3.21, P < 0.001) were the main factors associated with PPM occurrence. Compared with measured PPM, predicted PPM showed stronger association with high residual gradient. Severe measured or predicted PPM was not associated with clinical outcomes. CONCLUSION The utilization of the predicted EOAi reclassifies the majority of patients with PPM to no PPM following TAVR. Compared with measured PPM, predicted PPM had stronger association with haemodynamic outcomes, while both methods were not associated with clinical outcomes.
Epitope-specific antibody responses to a Plasmodium falciparum subunit vaccine target in a malaria-endemic population.

Circumsporozoite protein (CSP) coats the Plasmodium falciparum sporozoite surface and is a major malaria subunit vaccine target. We measured epitope-specific reactivity to field-derived CSP haplotypes in serum samples from Malian adults and children on a custom peptide microarray. Compared to children, adults showed greater antibody responses and responses to more variants in regions proximal to and within the central repeat region. Children acquired short-lived immunity to an epitope proximal to the central repeat region but not to the central repeat region itself. This approach has the potential to differentiate immunodominant from protective epitope-specific responses when combined with longitudinal infection data.
The Study on the Whole Stress–Strain Curves of Coral Fly Ash-Slag Alkali-Activated Concrete under Uniaxial Compression

This study aimed to research the whole stress–strain curves of coral Fly Ash-Slag Alkali-Activated Concrete (CAAC) in different strength grades. Fly ash-slag alkali-activated concrete was used as cementing materials to produce coral aggregate concrete. A monotonic loading test was conducted on the prismatic specimens to obtain elastic modulus (Ec), Poisson’s ratio (μ) and the constitutive relationship of CAAC under uniaxial compression. When the strain of CAAC reached the maximum value, the specimen was split and damaged rapidly. As the strength grade increased, the ratio of residual stress (σri) to peak stress (σ0i) decreased in the range of 0.17–0.28. The Ec of CAAC increased gradually, and μ increased to the peak value and then decreased. According to the test results, the constitutive equation of CAAC can be expressed by piecewise expression, which can better reflect all the experimental characteristics. It was also found that CAAC has many similar characteristics with coral concrete and lightweight aggregate concrete. To improve the strength and toughness of CAAC, some fibers, such as organic fiber, can be added to expand the application of CAAC in engineering projects.
A new Cuspidariid bivalve Rhinoclama (Rhinoclama) tsugaruensis n. sp. (Bivalvia: Cuspidariidae) from Tsugaru Strait, northern Japan

: A new species of septibranch bivalve is described from the Tsugaru Strait and Otsuchi Bay, northern Japan at depths ranging from 25 m to 200 m. The systematic status and species afﬁliation of Rhinoclama are brieﬂy reviewed in this paper, to place the new species in the context of the genus. Rhinoclama is here found to contain 3 species groups, mainly based on rostrum morphology; the brevirostris species-group (= subgenus Austroneaera , with poorly developed rostrum), alta species-group (= species of Rhinoclama s.s. , with straight developed rostrum) and adamsi species-group (= species of Rhinoclama s.s. , with developed and upturned rostrum). R. tsugaruensis fits in the last species group, and differs from R. adamsi and R. rugata by the absence of concentric sculpture on the shell disc. This small-sized Cuspidariid is here described as Rhinoclama ( Rhinoclama ) tsugaruensis n. sp.
Engineering serine integrase-based synthetic gene circuits for cellular memory and counting

A cellular counting system based on synthetic gene circuits would enable complex biological programming and be used in many biotechnology applications. Although a variety of synthetic memory circuits have been constructed, basic modules that can be assembled into a counting system are lacking. This thesis focuses on engineering a binary counting module, which can alternate between two states in response to a single repeating input signal. The highly directional large serine bacteriophage integrases were utilised as the basis for the synthetic circuits constructed in this study. Integrases and their protein co-factors, the recombination directionality factor (RDF) can change the orientation of a specific DNA segment flanked by two recombination sites. Integrase alone switches the orientation in one direction, and this directionality is reversed by the addition of its corresponding RDF. The two orientations can be used to turn gene expression on and off, leading to distinct output states which can be thought of as representing a single binary digit (0 and 1) heritably stored in the DNA. In this study, three different serine integrase-based synthetic gene circuits for cellular memory and counting were engineered and characterised. A set-reset latch was first constructed. By expressing ϕC31 integrase and co-expressing integrase with RDF Gp3 from two independent inducible systems, the orientation of the invertible DNA in the set-reset latch was inverted and restored respectively. This device demonstrated that ϕC31 integrase can successfully encode information into plasmid DNA. Next, a state-based latch was constructed, in which the gp3 gene was placed inside the invertible DNA segment to couple its transcriptional regulation to the circuit state. Integrase expression triggered by one input signal resulted in inversion of the invertible DNA, placing the gp3 gene in the correct orientation for transcription. Gp3 expression can then be triggered by another input signal to reverse the directionality of integrase, restoring the DNA back to its original configuration. By optimising the stoichiometry and kinetics of integrase and Gp3 expression, efficient switching of both multi-copy plasmid and single copy chromosomal DNA was achieved. Finally, the state-based latch was developed into a binary counting module by introducing a delay mechanism, in which gp3 transcription was inhibited by a state-based repressor during recombination requiring the absence of Gp3. Placing expression of gp3 under the control of the invertible DNA, allowed a single input signal controlling only integrase expression to switch the module between OFF (0) and ON (1). This is the first integrase-based module that generates different outputs in response to the same input signal and a fundamental step towards building a genetic binary counter with large counting capacity.
The N‐glycan profile in cortex and hippocampus is altered in Alzheimer disease

Protein glycosylation is crucial for the central nervous system and brain functions, including processes that are defective in Alzheimer disease (AD) such as neurogenesis, synaptic function, and memory formation. Still, the roles of glycans in the development of AD are relatively unexplored. Glycomics studies of cerebrospinal fluid (CSF) have previously shown altered glycosylation pattern in patients with different stages of cognitive impairment, including AD, compared to healthy controls. As a consequence, we hypothesized that the glycan profile is altered in the brain of patients with AD and analyzed the asparagine‐linked (N‐linked) glycan profile in hippocampus and cortex in AD and control brain. Glycans were enzymatically liberated from brain glycoproteins and analyzed by liquid chromatography‐tandem mass spectrometry (LC‐MS/MS). Eleven glycans showed significantly different levels in hippocampus compared to cortex in both control and AD brain. Two glycans in cortex and four in hippocampus showed different levels in AD compared to control brain. All glycans that differed between controls and AD brain had similar structures with one sialic acid, at least one fucose and a confirmed or potential bisecting N‐acetylglucosamine (GlcNAc). The glycans that were altered in AD brain differed from those that were altered in AD CSF. One glycan found to be present in significantly lower levels in both hippocampus and cortex in AD compared to control contained a structurally and functionally interesting epitope that we assign as a terminal galactose decorated with fucose and sialic acid. Altogether, these studies suggest that protein glycosylation is an important component in the development of AD and warrants further studies.
Evaluation of immunomodulatory effects of methanol extract of Elaeocarpus ganitrus seeds.

The seeds of Rudraksha ( Elaeocarpus ganitrus ) have been traditionally used in India and other Asian countries. The methanolic extract of Elaeocarpus ganitrus (EGM) seeds were evaluated for immunomodulatory activity using in vitro and in vivo methodologies. Effect of the extract at various concentrations (832-6.5 μg/ml) on secretion of mediators like nitric oxide, superoxide and lysosomal enzyme from isolated murine peritoneal macrophages were evaluated. The extract showed significant stimulation of release of nitric oxide (at 416, 104, 52 μg/ml), superoxide (at 416, 208 μg/ml) and lysosomal enzyme (at 208, 104 μg/ml). The extract was also evaluated for in vivo phagocytic activity by carbon clearance assay in mice and it showed significant increase in the phagocytic index at 100 and 200mg/kg dose. The effect of the extract in delayed type hypersensitivity (DTH) and antibody titre assay were evaluated in ovalbumin immunized mice. The extract showed significant stimulation of DTH response at 200 mg/kg dose and antibody titer at 100 and 200 mg/kg dose. The effect of EGM extract in cyclophosphamide induced myelosuppressed mice was not significant. The results suggest that EGM influences both non-specific (phagocytosis) and specific (cell mediated and humoral) arms of immune system.
Consensual Sexting among College Students: The Interplay of Coercion and Intimate Partner Aggression in Perceived Consequences of Sexting

Recent empirical data suggests that the majority of adolescents and emerging adults utilize digital technology to engage with texting and social media on a daily basis, with many using these mediums to engage in sexting (sending sexual texts, pictures, or videos via digital mediums). While research in the last decade has disproportionately focused on the potential risk factors and negative consequences associated with sexting, the data are limited by failing to differentiate consensual from non-consensual sexting and account for potential influences of intimate partner aggression (IPA) and sexting coercion in these contexts. In the current study, we assessed the positive and negative consequences associated with sexting, using behavioral theory as a framework, to determine the relationship between an individual’s personal history of IPA victimization and the perceived consequences. Undergraduate students (N = 536) who reported consensual sexting completed a series of measures examining their most recent sexting experience, including perceived sexting consequences, and their history of sexting coercion and IPA. Results suggested that those reporting a history of any type of IPA victimization endorsed more negative reinforcing consequences after sending a sext, and those with a history of physical or sexual IPA victimization endorsed more punishing consequences after sending a sext than those without such history. Additionally, experience with IPA was found to be positively correlated with perceived pressure/coercion to send a sext. The implications of these data for research, policy, prevention, and intervention are explored.
A phytosociological analysis of the Quercus coccifera L. stands in south Albania (NE Mediterranean)

Abstract The results of a phytosociological investigation of the Quercus coccifera L. stands occurring along the Adriatic and Ionian coasts in south Albania are given. The surveyed stands are localized in the Thermo-Mediterranean and Meso-Mediterranean belts. On the basis of literature and unpublished data, Q. coccifera stands extend from the shoreline up to 680 m of altitude, within the Quercetea ilicis vegetation zone. According to numerical analysis, Q. coccifera stands in south Albania can be divided into two broad groups forming macchia of 3–4 m height and low shrublands [0.5–1.5(-2) m)] defined primarily by degree of human pressure and altitudes. In addition, relevés from Q. coccifera stands in Albania were differentiated from Croatian and Montenegrin the Fraxino orni-Quercetum cocciferae associations. Conversely, Q. coccifera stands in south Albania share several biological and ecological similarities with those of the eastern Adriatic coast: hemicryptophytes prevailed and the chorological spectrum highlights a clear dominance of the steno-Mediterraneans. With respect to indicator values, an important differentiation from the eastern Adriatic associations was shown only in higher light intensity of the stands in Albania.
Shared decision making, aggression, and coercion in inpatients with schizophrenia

Abstract Background The present study aimed at answering three research questions: (a) Does shared decision making (SDM) yield similar effects for patients with involuntary admission or incidents of aggression compared to patients with voluntary admission or without incidents of aggression? (b) Does SDM reduce the number of patients with incidents of aggression and the use of coercive measures? (c) Does the use of coercion have a negative impact on patients’ perceived involvement in decision making? Methods We used data from the cluster-randomized SDM-PLUS trial in which patients with schizophrenia or schizoaffective disorder in 12 acute psychiatric wards of 4 German psychiatric hospitals either received an SDM-intervention or treatment as usual. In addition, data on aggression and coercive measures were retrospectively obtained from patients’ records. Results The analysis included n = 305 inpatients. Patient aggression as well as coercive measures mostly took place in the first days of the inpatient stay and were seldom during the study phase of the SDM-PLUS trial. Patients who had been admitted involuntarily or showed incidents of aggression profited similarly from the intervention with regard to perceived involvement, adherence, and treatment satisfaction compared to patients admitted voluntarily or without incidents of aggression. The intervention showed no effect on patient aggression and coercive measures. Having previously experienced coercive measures did not predict patients’ rating of perceived involvement. Conclusion Further research should focus on SDM-interventions taking place in the very first days of inpatients treatment and potential beneficial long effects of participatory approaches that may not be measurable during the current inpatient stay.
Genome-Wide Identification of CsATGs in Tea Plant and the Involvement of CsATG8e in Nitrogen Utilization

Nitrogen (N) is a macroelement with an indispensable role in the growth and development of plants, and tea plant (Camellia sinensis) is an evergreen perennial woody species with young shoots for harvest. During senescence or upon N stress, autophagy has been shown to be induced in leaves, involving a variety of autophagy-related genes (ATGs), which have not been characterized in tea plant yet. In this study, a genome-wide survey in tea plant genome identified a total of 80 Camellia Sinensis autophagy-related genes, CsATGs. The expression of CsATG8s in the tea plant showed an obvious increase from S1 (stage 1) to S4 (stage 4), especially for CsATG8e. The expression levels of AtATGs (Arabidopsis thaliana) and genes involved in N transport and assimilation were greatly improved in CsATG8e-overexpressed Arabidopsis. Compared with wild type, the overexpression plants showed earlier bolting, an increase in amino N content, as well as a decrease in biomass and the levels of N, phosphorus and potassium. However, the N level was found significantly higher in APER (aerial part excluding rosette) in the overexpression plants relative to wild type. All these results demonstrated a convincing function of CsATG8e in N remobilization and plant development, indicating CsATG8e as a potential gene for modifying plant nutrient utilization.
Evaluation of the Performance of Algorithm-Based Methods for Subjective Refraction

Objective: To evaluate the performance of two subjective refraction measurement algorithms by comparing the refraction values, visual acuity, and the time taken by the algorithms with the standard subjective refraction (SSR). Methods: The SSR and two semi-automated algorithm-based subjective refraction (SR1 and SR2) in-built in the Vision-R 800 phoropter were performed in 68 subjects. In SR1 and SR2, the subject’s responses were recorded in the algorithm which continuously modified the spherical and cylindrical component accordingly. The main difference between SR1 and SR2 is the use of an initial fogging step in SR1. Results: The average difference and agreement limits intervals in the spherical equivalent between each refraction method were smaller than 0.25 D, and 2.00 D, respectively. For the cylindrical components, the average difference was almost zero and the agreement limits interval was less than 0.50 D. The visual acuities were not significantly different among the methods. The times taken for SR1 and SR2 were significantly shorter, and SR2 was on average was three times faster than SSR. Conclusions: The refraction values and the visual acuity obtained with the standard subjective refraction and algorithm-based methods were similar on average. The algorithm-based methods were significantly faster than the standard method.
Optimization of Process Conditions for Biotransformation of Caffeine to Theobromine using Induced Whole Cells of Pseudomonas sp

The obromine is a metabolic intermediate produced in caffeine degradation pathway by many bacterial species, which has potential applications in food and pharmaceutical industries. Conventional methods of Theobromine production from xanthine involve harsh physical and chemical conditions which are harmful to the environment. To overcome this, we employed biotechnological route to convert caffeine to theobromine by single demethylation reaction using induced cells of Pseudomonas sp. Initially we screened various divalent metal ions for the production of Theobromine by Pseudomonas sp. from caffeine. Co2+ and Ni2+ accumulates 400 and 100 mg/l of theobromine under initial reaction conditions (2 g/l caffeine, 8 g/l cell loading, pH 7.0,30°C). Co2+ was chosen for further optimization of reaction conditions for Theobromine production using response surface methodology. Data were fitted into a quadratic model and the optimal condition for theobromine production was found to be 3.2 g/l caffeine, 11.3 g/l initial cell loading and pH 7.0. Quadratic regression models were validated at the optimized conditions and the experimental theobromine produced 689.7 mg/l corresponds to the model predicted theobromine 729.4 mg/l. Theobromine production was further improved to 1.08 ± 0.10 g/l by optimizing the reaction temperature. This study reports highest production of theobromine from caffeine using induced cells of Pseudomonas sp. Induced cells are better suited for metabolite production as it is metabolically very active and can be re-used several times. Optimization of reactor parameters will enable us to make microbial production of theobromine feasible in industries at reduced cost.
Correlates of Meeting the Physical Activity, Sedentary Behavior, and Sleep Guidelines for the Early Years among Belgian Preschool Children: The ToyBox-Study

Physical activity, sedentary behavior, and sleep guidelines for preschool children were already established and integrated into the 24 h movement behavior guidelines in 2017. The aim of the current study was to investigate correlates of meeting or not meeting the physical activity, sedentary behavior, and sleep guidelines in Belgian preschool children. In total, 595 preschool children (53.3% boys, 46.7% girls, mean age: 4.2 years) provided complete data for the three behaviors and potentially associated correlates. Physical activity was objectively measured with accelerometers. Screen time, sleep duration, and correlates were reported by parents with the use of a questionnaire. Backward logistic regression was used to identify factors associated with meeting all guidelines for weekdays and weekend days. In the final model, older preschoolers (OR = 1.89), having a normal weight compared to being underweight (OR = 0.30), having parents that do not watch a lot of television (OR = 0.99), and having a father that attained higher education (OR = 1.91) were associated with meeting all guidelines on weekdays. For weekend days, a significant association was found for attending a sports club (OR = 1.08). Overall, only a few factors were associated with meeting the guidelines. A more comprehensive measurement of preschool children’s potential correlates of physical activity, sedentary behavior, and sleep is warranted.