Miracle-dz/UniFAR-FTUs huggingface dataset:
Preschool, Day Care, and Afterschool Care: Who&Apos;S Minding the Kids?

The majority of children in the U.S. and many other high-income nations are now cared for many hours per week by people who are neither their parents nor their school teachers. The role of such preschool and out of school care is potentially two-fold: First, child care makes it feasible for parents to be employed. Second, early intervention programs and after school programs aim to enhance child development, particularly among disadvantaged children. Corresponding to this distinction, the literature has two branches. The first focuses on the market for child care and analyzes factors affecting the supply, demand, and quality of care. The second focuses on child outcomes and asks whether certain types of programs can ameliorate the effects of early disadvantage. The primary goal of this review is to bring the two literatures together in order to suggest ways that both may be enhanced. Accordingly, we provide an overview of the number of children being cared for in different sorts of arrangements; describe theory and evidence about the nature of the private child care market; and discuss theory and evidence about government intervention in the market for child care. Our summary suggests that additional research is necessary to highlight the ways that government programs and market provided child care interact with each other.
Employing stable isotopes to determine the residence times of soil water and the temporal origin of water taken up by Fagus sylvatica and Picea abies in a temperate forest.

We assessed how the seasonal variability of precipitation δ2 H and δ18 O is propagated into soil and xylem waters of temperate trees, applied a hydrological model to estimate the residence time distribution of precipitation in the soil, and identified the temporal origin of water taken up by Picea abies and Fagus sylvatica over 4 yr. Residence times of precipitation in the soil varied between a few days and several months and increased with soil depth. On average, 50% of water consumed by trees throughout a year had precipitated during the growing season, while 40% had precipitated in the preceding winter or even earlier. Importantly, we detected subtle differences with respect to the temporal origin of water used by the two species. We conclude that both current precipitation and winter precipitation are important for the water supply of temperate trees and that winter precipitation could buffer negative impacts of spring or summer droughts. Our study additionally provides the means to obtain realistic estimates of source water δ2 H and δ18 O values for trees from precipitation isotope data, which is essential for improving model-based interpretations of δ18 O and δ2 H values in plants.
Hepatitis B virus limits response of human hepatocytes to interferon-α in chimeric mice.

BACKGROUND & AIMS Interferon (IFN)-α therapy is not effective for most patients with chronic hepatitis B virus (HBV) infection for reasons that are not clear. We investigated whether HBV infection reduced IFN-α-mediated induction of antiviral defense mechanisms in human hepatocytes. METHODS Human hepatocytes were injected into severe combined immune-deficient mice (SCID/beige) that expressed transgenic urokinase plasminogen activator under control of the albumin promoter. Some mice were infected with HBV; infected and uninfected mice were given injections of human IFN-α. Changes in viral DNA and expression of human interferon-stimulated genes (ISGs) were measured by real-time polymerase chain reaction, using human-specific primers, and by immunohistochemistry. RESULTS Median HBV viremia (0.8log) and intrahepatic loads of HBV RNA decreased 3-fold by 8 or 12 hours after each injection of IFN-α, but increased within 24 hours. IFN-α activated expression of human ISGs and nuclear translocation of signal transducers and activators of transcription-1 (STAT1) in human hepatocytes that repopulated the livers of uninfected mice. Although baseline levels of human ISGs were slightly increased in HBV-infected mice, compared with uninfected mice, IFN-α failed to increase expression of the ISGs OAS-1, MxA, MyD88, and TAP-1 (which regulates antigen presentation) in HBV-infected mice. IFN-α did not induce nuclear translocation of STAT1 in HBV-infected human hepatocytes. Administration of the nucleoside analogue entecavir (for 20 days) suppressed HBV replication but did not restore responsiveness to IFN-α. CONCLUSIONS HBV prevents induction of IFN-α signaling by inhibiting nuclear translocation of STAT1; this can interfere with transcription of ISGs in human hepatocytes. These effects of HBV might contribute to the limited effectiveness of endogenous and therapeutic IFN-α in patients and promote viral persistence.
CO2 enrichment and soil type additively regulate grassland productivity.

Atmospheric CO2 enrichment usually increases the aboveground net primary productivity (ANPP) of grassland vegetation, but the magnitude of the ANPP-CO2 response differs among ecosystems. Soil properties affect ANPP via multiple mechanisms and vary over topographic to geographic gradients, but have received little attention as potential modifiers of the ANPP-CO2 response. We assessed the effects of three soil types, sandy loam, silty clay and clay, on the ANPP response of perennial C3 /C4 grassland communities to a subambient to elevated CO2 gradient over 10 yr in Texas, USA. We predicted an interactive, rather than additive, effect of CO2 and soil type on ANPP. Contrary to prediction, CO2 and soil additively influenced grassland ANPP. Increasing CO2 by 250 μl l-1 increased ANPP by 170 g m-2 across soil types. Increased clay content from 10% to 50% among soils reduced ANPP by 50 g m-2 . CO2 enrichment increased ANPP via a predominant direct effect, accompanied by a smaller indirect effect mediated by a successional shift to increased dominance of the C4 tallgrass Sorghastrum nutans. Our results indicate a large, positive influence of CO2 enrichment on grassland productivity that resulted from the direct physiological benefits of CO2 augmented by species succession, and was expressed similarly across soils of differing physical properties.
An Exploration of Managers' Discourses of Workplace Bullying.

AIM To identify discourses used by hospital nursing unit managers to characterize workplace bullying, and their roles and responsibilities in workplace bullying management. BACKGROUND Nurses around the world have reported being the targets of bullying. These nurses often report that their managers do not effectively help them resolve the issue. There is scant research that examines this topic from the perspective of managers. METHODS This was a descriptive, qualitative study. Interviews were conducted with hospital nursing unit managers who were recruited via purposive and snowball sampling. Data were analyzed using Willig's Foucauldian discourse analysis. RESULTS Managers characterized bullying as an interpersonal issue involving the target and the perpetrator, as an intrapersonal issue attributable to characteristics of the perpetrator, or as an ambiguous situation. For interpersonal bullying, managers described supporting target's efforts to end bullying; for intrapersonal bullying, they described taking primary responsibility; and for ambiguous situations, they described several actions, including doing nothing. CONCLUSION Managers have different responses to different categories of bullying. Efforts need to be made to make sure they are correctly identifying and appropriately responding to incidents of workplace bullying.
Dissecting the Immune Response Elicited by WbALT-2, ALT MAP in Clinical Populations and Mouse Model: A Prophylactic Measure Against Lymphatic Filariasis.

BACKGROUND Abundant Larval Transcript (ALT) is one of the major groups of immune-dominant proteins produced by filarial worms during their larval stage. The major B-cell and T-cell epitopic domains of the ALT-2 antigen were mapped to develop a multiple antigenic peptide (MAP) prophylactic antigen against lymphatic filariasis. METHODS AND RESULTS ALT MAP was constructed by solid phase peptide synthesis. The reactivity of whole ALT protein and ALT MAP against clinical sera described a high reactivity of endemic normal sera against ALT MAP compared to WbALT-2 protein. The antibody isotype pattern revealed elevated levels of IgG1 and IgG2 against ALT MAP, followed by IgG3 and IgG4. In this study we also analyzed the immune response pattern elicited by ALT MAP, ALT in mice models, which revealed similar pattern of humoral response, while low T cell proliferation in ALT MAP groups. The low proliferation could be attributed to T/B epitope arrangement on the construct, MHC restriction, and incomplete signal delivery by T cell receptor. CONCLUSION The immunodominant epitopes in ALT MAP were found to play a crucial role in inducing high antigen specific proliferation. This revealed the significance of ALT MAP in stimulating innate immunity in offering protective immune response probably through the activation of complement cascade along with stimulation of cellular response. An improved understanding, including the construction of ALT MAP and parasite challenge study in jirds to determine the worm clearance would give a better insight in the characterization ALT MAP construct as a prophylactic vaccine candidate.
Traditional versus Western perceptions of mental illness: women of Moroccan origin treated in an Israeli mental health center

This paper focuses on the problems encountered in providing Westernized psychiatric treatment to a population with traditional healing beliefs. The sample comprised women of Moroccan origin living in Israel undergoing treatment for psychiatric disorders (N=38), and their treating psychiatrists (N=9). Ethnographic interviews were conducted among both groups. The results revealed that the symptoms, perceptions of the illness, and problems encountered in the therapeutic relationship differed across three age groups, young women (20–30 years), more mature women (31–42 years), and older women (43–60 years). While cultural conflict appeared to affect the development of mental illness in each group, this was most pronounced among women in the middle age range. Moreover, problems in the therapeutic alliance were greatest in this age group. The data from the therapists indicated that they maintained a Western perspective in both their understanding and diagnoses of these patients' illnesses. The different perspectives of the therapists and each of the three groups of women are discussed. It is concluded that professionals treating traditional populations must avoid imposing Western standards, and consider the treatment in the context of cultural beliefs. The developmental stages of the individual, and the stage of acculturation must also be taken into account if treatment is to be effective.
Rural Church of England Primary Schools: Listening to Denominational Inspectors

Abstract This article examines the roots of today's Church of England primary schools and some of the major legislation that continues to shape the state-funded dual system of church and county schools in England and Wales. Pressures on church schools and the long-standing controversy surrounding the dual system are discussed, as is the Church of England's response through its current plan of action. Key research into changes in teacher attitudes to the distinctiveness of church schools arrived at the striking and unpredicted conclusion that teachers working in church schools in 1996 were more positive in their attitude to the distinctiveness of church schools than teachers working in such schools in 1982. This is convincingly explained by linking the changes in attitude to the launch of the denominational inspection system, and its associated training, brought about by the introduction of the Education (Schools) Act 1992. The article draws on evidence from the denominational inspection system on the distinctiveness and effectiveness of church schools. Recent denominational inspectors’ reports are analysed to discover the quality of education provided by 58 small rural church primary schools in England. Conclusions about the education provided in these schools and ways forward for small rural primary church schools are offered. Possibilities for future research are given.
Effects of progressive resistance training combined with a protein-enriched lean red meat diet on health-related quality of life in elderly women: secondary analysis of a 4-month cluster randomised controlled trial

Abstract Resistance training (RT) and increased dietary protein are recommended to attenuate age-related muscle loss in the elderly. This study examined the effect of a lean red meat protein-enriched diet combined with progressive resistance training (RT+Meat) on health-related quality of life (HR-QoL) in elderly women. In this 4-month cluster randomised controlled trial, 100 women aged 60–90 years (mean 73 years) from self-care retirement villages participated in RT twice a week and were allocated either 160 g/d (cooked) lean red meat consumed across 2 meals/d, 6 d/week or ≥1 serving/d (25–30 g) carbohydrates (control group, CRT). HR-QoL (SF-36 Health Survey questionnaire), lower limb maximum muscle strength and lean tissue mass (LTM) (dual-energy X-ray absorptiometry) were assessed at baseline and 4 months. In all, ninety-one women (91 %) completed the study (RT+Meat (n 48); CRT (n 43)). Mean protein intake was greater in RT+Meat than CRT throughout the study (1·3 (sd 0·3) v. 1·1 (sd 0·3) g/kg per d, P<0·05). Exercise compliance (74 %) was not different between groups. After 4 months there was a significant net benefit in the RT+Meat compared with CRT group for overall HR-QoL and the physical component summary (PCS) score (P<0·01), but there were no changes in either group in the mental component summary (MCS) score. Changes in lower limb muscle strength, but not LTM, were positively associated with changes in overall HR-QoL (muscle strength, β: 2·2 (95 % CI 0·1, 4·3), P<0·05). In conclusion, a combination of RT and increased dietary protein led to greater net benefits in overall HR-QoL in elderly women compared with RT alone, which was because of greater improvements in PCS rather than MCS.
Vitamin D deficiency, oxidative stress and antioxidant status: only weak association seen in the absence of advanced age, obesity or pre-existing disease

Abstract Vitamin D deficiency (plasma 25-hydroxycholecalciferol (25(OH)D)<50 nmol/l) is highly prevalent, increases risk of non-communicable diseases (NCD) and associates with increased oxidative stress in obese subjects, the elderly and patients suffering from NCD. If confirmed as an independent driver of oxidative stress, nutritional and other public health strategies to improve vitamin D status would be strongly supported. We investigated vitamin D/oxidative stress links without the confounding effects of advanced age, obesity, smoking or pre-existing disease. Plasma 25(OH)D and biomarkers of oxidative stress and antioxidant status (plasma allantoin, oxidised LDL, ferric reducing antioxidant power (FRAP), ascorbic acid, urine 8-oxo-7,8-dihydro-2'-deoxyguanosine) were measured in fasting samples from 196 consenting, healthy adults aged 18–26 years. Correlation between 25(OH)D and each biomarker as well as biomarker differences across 25(OH)D quartiles and groups (<25/25–49/≥50 nmol/l) were investigated. Median 25(OH)D was 40 nmol/l; >70 % of participants were vitamin D deficient. No significant correlations and no biomarker differences across 25(OH)D quartiles or groups were seen except for total antioxidant status. A weak direct association (r 0·252, P<0·05) was observed between 25(OH)D and FRAP, and those in the lowest 25(OH)D quartile and group had significantly lower FRAP values. Results did not reveal a clear link between vitamin D status and oxidative stress biomarkers in the absence of advanced age, obesity and disease, though some evidence of depleted antioxidant status in those with vitamin D deficiency was seen. Poor antioxidant status may pre-date increased oxidative stress. Study of effects of correction of deficiency on antioxidant status and oxidative stress in vitamin D-deficient but otherwise healthy subjects is needed.
The effect of time of day on hormonal responses to resistance exercise

The aim of this study was to examine the acute hormonal responses to resistance training performed in the morning or in the evening. Eighteen active men underwent two lower body resistance exercise (RE) sessions (3 × 10 repetitions, maximum of four exercises) on two occasions (07:00 and 17:00 h). Blood samples were collected in the morning and evening before (BT), after (AT), and 60 min after (60-AT) the RE training session for the determination of testosterone (T) and cortisol (C) concentrations. The Δ-changes of T and C concentrations were calculated as the difference between AT and BT, the difference between 60-AT and BT, as well as the difference between 60-AT and AT. The results showed that T increased from BT to AT and decreased from AT to 60-AT at the two times of testing. However, T was higher in the evening and lower in morning at 60-AT compared with BT. C increased from BT to AT and 60-AT in the evening, and decreased from AT to 60-AT at the two times of testing. Likewise, Δ-changes of T and C concentrations between AT and BT and between 60-AT and BT were higher in the evening than in the morning. In conclusion, training-induced hormonal responses are observed to be greater in the evening than in the morning, which potentially provides a more favorable profile for anabolism.
Preferential expression of integrin αvβ8 promotes generation of regulatory T cells by mouse CD103+ dendritic cells.

BACKGROUND & AIMS Immune responses in the intestine are controlled by regulatory T cells (Tregs), which prevent inflammation in response to commensal bacteria. A specific population of intestinal dendritic cells (DCs), marked by expression of CD103, generate Tregs more efficiently than other DC populations through mechanisms that involve retinoic acid and transforming growth factor (TGF)-β. However, it is not clear how CD103(+) DCs are specialized for this function. We investigated the ability of CD103(+) DCs to promote Treg generation through activation of TGF-β and the role of integrins with the αv subunit in this process. METHODS Naïve T cells were cultured with purified DCs from mesenteric lymph nodes (MLNs) or intestines of wild-type and αv conditional knockout mice to assess generation of Tregs. Antigens were administered orally to mice, and antigen-specific generation of Tregs was measured in intestinal tissues. Expression of the integrin αv subunit was measured in purified subpopulations of DCs by quantitative polymerase chain reaction and immunoblot analyses. RESULTS In vitro, CD103(+) DCs generated more Tregs in the presence of latent TGF-β than other MLN DCs. Efficient generation of Tregs required expression of the integrin αv subunit by DCs; mice that lacked αv in immune cells did not convert naïve T cells to intestinal Tregs in response to oral antigen. CD103(+) DCs derived from the MLNs selectively expressed high levels of integrin αvβ8 compared with other populations of DCs. CONCLUSIONS Expression of αvβ8 is required for CD103(+) DCs to become specialized and activate latent TGF-β and generate Tregs during the induction of tolerance to intestinal antigens in mice.
Evidence-based veterinary medicine 2. Identifying information needs and finding the evidence

THE first article in this three-part series (In Practice, January 2004, pp 28-33) explained the importance of evidence-based veterinary medicine (EBVM) and described the range of skills required to practise it. The first step in the process of EBVM is to identify information needs and translate these needs into scientific questions. This article discusses how to do this, as well as how to locate sources of evidence and then search for evidence. Part 3, to be published in the next issue, will be concerned with appraising the evidence.
Prospective association between adherence to dietary recommendations and incident depressive symptoms in the French NutriNet-Santé cohort

Abstract A posteriori healthier dietary patterns and several nutrients have been associated with lower risks of depression in various studies; however, evidence is lacking with regard to the prospective association between adherence to nutritional recommendations (food-based and nutrient-based recommendations) and incident depression or depressive symptoms. In this study, we investigate such associations in the NutriNet Santé cohort. The study sample included 26 225 participants (aged 18–86 years) who were initially free of depressive symptoms. Adherence to nutritional recommendations was measured by four scores namely modified French Programme National Nutrition Santé-Guideline Score (mPNNS-GS), Alternative Healthy Eating Index-2010 (AHEI-2010), Probability of Adequate Nutrient Intake Dietary Score (PANDiet) and Diet Quality Index-International (DQI-I), using non-consecutive dietary record data during the first 2 years of follow-up (mean number of recording days=8, sd 2). Depressive symptoms were defined by a Center for Epidemiologic Studies Depression Scale (CES-D) score ≥17 for men and ≥23 for women. We used Cox proportional hazards models to estimate hazard ratios and 95 % CI, modelling the dietary scores as standardised continuous variables and as tertiles. Over a mean follow-up of 6 years, we identified 2166 incident cases of depressive symptoms. All dietary scores with the exception of the AHEI-2010 were significantly inversely associated with incident depressive symptoms. In the fully adjusted model, an increase of 1 sd in the mPNNS-GS, PANDiet and DQI-I was, respectively, associated with an 8 % (95 % CI 4, 13), 5 % (95 % CI 1, 9) and 9 % (95 % CI 5, 13) reduction in the risk of depressive symptoms. Overall, these findings suggest that diet in accordance with national or international guidelines could have beneficial effects with regard to mental health.
Non-compliance in gentamicin prescribing and administration: A patient safety issue

Abstract Importance: Extensive use of antibiotics requiring dose-monitoring and weight-based prescribing can reduce compliance, risking morbidity, and mortality from sepsis. Objective: To determine if gentamicin was being prescribed according to recommendations in the British National Formulary and trust guidelines. Methods: All patients prescribed gentamicin in a one-month period on electronic prescribing were included. Data comprised demographics, admission specialty, dosing regime prescribed, number of doses received, actual dose, and recorded reasons for non-administration. Results: 374 patients were prescribed gentamicin over one month. 223 were prescribed stat doses (207 received, 16 not given; 93% compliance). The remaining 151 patients were on multidose prescriptions, between 3 and 7 doses. 25 received zero doses, 41 a single dose, 50 patients received two doses, and 35 received three doses or greater (23% compliance with guidelines). Conclusion: Antibiotics are essential in treating and preventing sepsis but must be used appropriately. Sensitivities should be used to guide antibiotic prescription; however, generic guidelines must consider the practicalities of antibiotic regimes requiring weight-based dosing and monitoring. When it is necessary, these regimes can be easily adhered to, but when the guidelines result in large numbers of patients requiring monitoring, compliance will be affected, and as a result morbidity and mortality from sepsis rises.
Effective fractal dimensions

Classical fractal dimensions (Hausdorff dimension and packing dimension) have recently been effectivized by (i) characterizing them in terms of real‐valued functions called gales, and (ii) imposing computability and complexity constraints on these gales. This paper surveys these developments and their applications in algorithmic information theory and computational complexity theory. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)