Miracle-dz/UniFAR-FTUs huggingface dataset:
Public Opinion Analysis based on Probabilistic Topic Modeling and Deep Learning

With the rapid development of Internet, especially the social media technologies, the public have gradually published their perception of social events online through social media. In Web2.0 era, with the concept of extensive participation of public in social-event-related information sharing, the effective content analysis and better results presentation for these media published online thus possesses significant importance for public opinion analysis and monitoring. In view of this, this paper proposes a novel method for public opinion analysis on social media website. First, the probabilistic topic model of Latent Dirichlet Allocation (LDA) is adopted to extract the public ideas about the distinct topics of certain event, and then the deep learning model named word2vec is used to calculate the emotional intensity for each text. Next, the underlying themes in the whole as well as the events of emotional intensity are investigated, and the variation trend of public’s emotion intensities is tracked based on time series analysis. Finally, the rationality and effectiveness of the method are verified with the analysis of a real case.
Role of Na+ and Li+ in thiomethylgalactoside transport by the melibiose transport system of Escherichia coli

Thiomethyl-beta-galactoside (TMG) accumulation via the melibiose transport system was studied in lactose transport-negative strains of Escherichia coli. TMG uptake by either intact cells or membrane vesicles was markedly stimulated by Na+ or Li+ between pH 5.5 and 8. The Km for uptake of TMG was approximately 0.2 mM at an external Na+ concentration of 5 mM (pH 7). The alpha-galactosides, melibiose, methyl-alpha-galactoside, and o-nitrophenyl-alpha-galactoside had a high affinity for this system whereas lactose, maltose and glucose had none. Evidence is presented for Li+-TMG or Na+-TMG cotransport.
Kaposi's sarcoma in a two week old infant born to a mother with Kaposi's sarcoma/AIDS.

Kaposiâ€™s sarcoma in very young children is extremely rare, and the literature search has revealed only one case of Kaposiâ€™s sarcoma in an infant of less than four weeks of age.1 Cases involving older children are very rare in Europe and North America2 but are suspected to be more common in African children whose mothers are infected with HIV.
Read Stability and Write-Ability Analysis of SRAM Cells for Nanometer Technologies

SRAM cell read stability and write-ability are major concerns in nanometer CMOS technologies, due to the progressive increase in intra-die variability and Vdd scaling. This paper analyzes the read stability N-curve metrics and compares them with the commonly used static noise margin (SNM) metric defined by Seevinck. Additionally, new write-ability metrics derived from the same N-curve are introduced and compared with the traditional write-trip point definition. Analytical models of all these metrics are developed. It is demonstrated that the new metrics provide additional information in terms of current, which allows designing a more robust and stable cell. By taking into account this current information, Vdd scaling is no longer a limiting factor for the read stability of the cell. Finally, these metrics are used to investigate the impact of the intra-die variability on the stability of the cell by using a statistically-aware circuit optimization approach and the results are compared with the worst-case or corner-based design
Approximate testing in two-stage nonlinear mixed models

We investigate here small sample properties of approximate F-tests about fixed effects parameters in nonlinear mixed models. For estimation of population fixed effects parameters as well as variance components, we apply the two-stage approach. This method is useful and popular when the number of observations per sampling unit is large enough. The approximate F-test is constructed based on large-sample approximation to the distribution of nonlinear least-squares estimates of subject-specific parameters. We recommend a modified test statistic that takes into consideration approximation to the large-sample Fisher information matrix (See [Volaufova J, Burton JH. Note on hypothesis testing in mixed models. Oral presentation at: LINSTAT 2012/21st IWMS; 2012; Bedlewo, Poland]). Our main focus is on comparing finite sample properties of broadly used approximate tests (Wald test and likelihood ratio test) and the modified F-test under the null hypothesis, especially accuracy of p-values (See [Volaufova J, LaMotte L. Comparison of approximate tests of fixed effects in linear repeated measures design models with covariates. Tatra Mountains. 2008;39:17–25]). For that purpose two extensive simulation studies are conducted based on pharmacokinetic models (See [Hartford A, Davidian M. Consequences of misspecifying assumptions in nonlinear mixed effects models. Comput Stat and Data Anal. 2000;34:139–164; Pinheiro J, Bates D. Approximations to the log-likelihood function in the non-linear mixed-effects model. J Comput Graph Stat. 1995;4(1):12–35]).
Use of Animal-Assisted Therapy in the Rehabilitation of an Assault Victim with a Concurrent Mood Disorder

Multidisciplinary mental health rehabilitation settings often encounter patients with complex comorbid medical and psychiatric issues that require integrative, multifaceted treatment strategies. Although medication and psychotherapy are typical treatment mainstays, a broader variety of therapeutic options are available, including animal-assisted therapy. Here we describe a patient who received animal-assisted therapy as a psychiatric rehabilitation tool to ameliorate his atypical depression following an assault and subsequent head injury. A review of the relevant literature highlights the therapeutic potential of animal-assisted therapy to restore and maintain patient independence and level of functioning, both of which are key treatment goals.
Deletion mapping of genetic regions associated with apomixis in Hieracium

Although apomixis has been quoted as a technology with the potential to deliver benefits similar in scale to those achieved with the Green Revolution, very little is currently known of the genetic mechanisms that control this trait in plants. To address this issue, we developed Hieracium, a genus of daisies native to Eurasia and North America, as a genetic model to study apomixis. In a molecular mapping study, we defined the number of genetic loci involved in apomixis, and we explored dominance and linkage relationships between these loci. To avoid difficulties often encountered with inheritance studies of apomicts, we based our mapping effort on the use of deletion mutagenesis, coupled with amplified fragment length polymorphism (AFLP) as a genomic fingerprinting tool. The results indicate that apomixis in Hieracium caespitosum is controlled at two principal loci, one of which regulates events associated with the avoidance of meiosis (apomeiosis) and the other, an unlinked locus that controls events associated with the avoidance of fertilization (parthenogenesis). AFLP bands identified as central to both loci were isolated, sequenced, and used to develop sequence-characterized amplified region (SCAR) markers. The validity of the AFLP markers was verified by using a segregating population generated by hybridization. The validity of the SCAR markers was verified by their pattern of presence/absence in specific mutants. The mutants, markers, and genetic data derived from this work are now being used to isolate genes controlling apomixis in this system.
DAWGS - A Distributed Compute Server Utilizing Idle Workstations

Abstract A collection of powerful workstations interconnected by a local area network forms a large computing resource. The problem of locating and efficiently using this resource has been the subject of much study. When the system is composed of workstations, an attractive technique may be employed to make use of workstations left idle by their owners. The Distributed Automated Workload balancinG System (DAWGS) is designed to allow users to utilize this networked computing power for their programs. Essentially, DAWGS is an interface between the user and the kernel which allows users to submit batch-type or interactive-type processes or jobs for execution on an idle workstation somewhere on a local area network. DAWGS uses a distributed scheduler based on a bidding scheme which resolves many of the problems with bidding to determine which machine to run a process on. It properly redirects all I/O from the remotely running process back to the machine from whence the process came. DAWGS is capable of checkpointing processes and restarting any type of process, including interactive ones, even when the restart is on a machine different than the one the process was previously running on. We show that running processes remotely on idle workstations can result in significantly lower execution times, particularly for processes with a large execution time. Our method is different from previous work in that it is fault-tolerant, maintains total remote execution transparency for the user, and is fully distributed.
Hepatic triglyceride synthesis and nonalcoholic fatty liver disease

Purpose of review Nonalcoholic fatty liver disease is a spectrum of diseases ranging from simple steatosis to cirrhosis. The hallmark of nonalcoholic fatty liver disease is hepatocyte accumulation of triglycerides. We will review the role of triglyceride synthesis in nonalcoholic fatty liver disease progression and summarize recent findings about triglyceride synthesis inhibition and prevention of progressive disease. Recent findings Attempts to inhibit triglyceride synthesis in animal models have resulted in improvement in hepatic steatosis. Studies in animal models of nonalcoholic fatty liver disease demonstrate that inhibition of acyl-coenzyme A:diacylglycerol acyltransferase, the enzyme that catalyzes the final step in triglyceride synthesis, results in improvement in hepatic steatosis and insulin sensitivity. We recently confirmed that hepatic specific inhibition of acyl-coenzyme A:diacylglycerol acyltransferase with antisense oligonucleotides improves hepatic steatosis in obese, diabetic mice but, unexpectedly, exacerbated injury and fibrosis in that model of progressive nonalcoholic fatty liver disease. When hepatocyte triglyceride synthesis was inhibited, free fatty acids accumulated in the liver, leading to induction of fatty acid oxidizing systems that increased hepatic oxidative stress and liver damage. These findings suggest that the ability to synthesize triglycerides may, in fact, be protective in obesity. Summary Nonalcoholic fatty liver disease is strongly associated with obesity and peripheral insulin resistance. Peripheral insulin resistance increases lipolysis in adipose depots, promoting increased free fatty acid delivery to the liver. In states of energy excess, such as obesity, the latter normally triggers hepatic triglyceride synthesis. When hepatic triglyceride synthesis is unable to accommodate increased hepatocyte free fatty acid accumulation, however, lipotoxicity results. Thus, rather than being hepatotoxic, liver triglyceride accumulation is actually hepato-protective in obese, insulin-resistant individuals.
Evaluation of a Xenogeneic Acellular Collagen Matrix as a Small-Diameter Vascular Graft in Dogs-Preliminary Observations

Autogenous veins are the materials of choice for arterial reconstruction. In the absence of autogenous material, prosthetic materials are used. However, vascular prostheses of less than 0.4 cm in diameter have low long-term patency. This study was designed to determine if cells would infiltrate an engineered xenogeneic biomaterial used as a smalldiameter arterial graft in dogs and, if so, to determine the phenotype of the infiltrating cells. Nine acellular xenogeneic grafts (0.4 cm in diameter, 5 cm long), composed of porcine collagen derived from the submucosa of the small intestine and type I bovine collagen, were implanted as end-to-end interposition grafts in femoral arteries of five male mongrel dogs (total of nine grafts). All dogs received daily aspirin (325 mg). Patency of implanted grafts was monitored weekly by Duplex ultrasonography. After 9 weeks, or earlier in case of blood flow reduction by at least 75%, grafts were explanted and prepared for light or electron microscopy to evaluate cellularization. Eight of nine grafts remained patent up to 9 weeks. At explant, diameters were 0.31 - 0.02 cm at the midgraft, and 0.14 - 0.01 and 0.19 - 0.01 cm at the proximal and distal anastomoses. At explant, cells of mesenchymal origin (endothelial cells, smooth muscle cells, myofibroblasts) were embedded in the extracellular matrix of the graft scaffold. Minimal evidence of cellular inflammatory reaction and no aneurysmal dilatation or thrombus formation was detected. Variable degrees of hyperplasia were present at proximal and distal anastomoses. This preliminary study demonstrates that a collagen-based xenogeneic biomaterial provides a scaffold for cellularization when used for arterial reconstruction in dogs.
Upper mantle structure of the southern Arabian margin: insights from teleseismic tomography

We image the lithospheric and upper asthenospheric structure beneath the central and eastern parts of the northern Gulf of Aden rifted passive continental margin with 59 broadband stations to evaluate the role of transform fault zones on the evolution of magma-poor continental margins. We used teleseismic tomography to compute a relative P wave velocity model in eastern Yemen and southern Oman down to 400 km depth. Our model shows low-velocity anomalies located in the vicinities of five major fracture zones and regions of recent volcanism. These low-velocity anomalies are likely caused by localized asthenospheric upwelling and partial melting, caused by small-scale convection promoted by gradients in the lithosphere-asthenosphere boundary topography near the fracture zones. In addition, low velocities underlie regions of elevated topography between major sedimentary basins. We suggest that locally buoyant mantle creates uplift and dynamic topography on the rift margin that affects the course of seasonal rivers and the sedimentation at the mouth of those rivers. Our new P wave velocity model suggests that the dynamic topography and recent volcanism in the central and eastern Gulf of Aden could be due to small-scale convection at the edge of the Arabian plate and/or in the vicinity of fracture zones.
A Long-Term, Open-Label, Safety Study of Triple-Bead Mixed Amphetamine Salts (SHP465) in Adults With ADHD

Objective: The aim of this study was to evaluate the long-term safety of triple-bead mixed amphetamine salts (MAS) in adults with ADHD. Method: Adults meeting Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.; DSM-IV-TR) ADHD criteria and satisfying study criteria from one of two antecedent studies were enrolled in this 52-week (dose titration, 4 weeks; dose maintenance, 11 months) open-label extension. The protocol included 12.5- to 75-mg triple-bead MAS but was amended to a maximum of 50-mg triple-bead MAS. Safety evaluations included treatment-emergent adverse events (TEAEs) and vital signs. Clinical outcome measures included ADHD Rating Scale–IV (ADHD-RS-IV) total score changes. Results: Of 505 enrolled participants, 266 completed the study; the M ± SD daily dose during the study was 48.0 ± 15.96 mg. The most frequent TEAEs were insomnia (initial insomnia, insomnia, early morning awakening, middle insomnia; 38.2%), headache (25.7%), and dry mouth (20.2%). Study discontinuations were more frequent with higher doses of triple-bead MAS (37.5-75 mg) than with lower doses (12.5 and 25 mg). Blood pressure and pulse increases were observed at end-of-study. Mean ADHD-RS-IV total score decreases from antecedent study and open-label baselines at end-of-study were −23.3 ± 11.44 and −7.9 ± 13.19, respectively. Conclusion: Triple-bead MAS exhibited a long-term safety profile comparable with previous reports and demonstrated evidence of continued symptom control for up to 12 months.
NLPIR: a Theoretical Framework for Applying Natural Language Processing to Information Retrieval

The role of information retrieval (IR) in support of decision making and knowledge management has become increasingly significant. Confronted by various problems in traditional keyword-based IR, many researchers have been investigating the potential of natural language processing (NLP) technologies. Despite widespread application of NLP in IR and high expectations that NLP can address the problems of traditional IR, research and development of an NLP component for an IR system still lacks support and guidance from a cohesive framework. In this paper, we propose a theoretical framework called NLPIR that aims at integrating NLP into IR and at generalizing broad application of NLP in IR. Some existing NLP techniques are described to validate the framework, which not only can be applied to current research, but is also envisioned to support future research and development in IR that involve NLP.
Real‐time changes of the local vasoactive peptide systems (angiotensin, endothelin) in the bovine corpus luteum after induced luteal regression

There is evidence that angiotensin II (Ang II) and endothelin‐1 (ET‐1) may interact in an additive or synergistic way during luteal regression. The aim of the study was to investigate real time changes in luteal tissue of angiotensin and endothelin system members in mRNA expression, tissue concentrations, tissue localization, and ACE (angiotensin converting enzyme) antagonist application after prostaglandin F2α (PG) induced (days 8–12) luteal regression in cow. Corpora lutea (CL) were collected by transvaginal ovaryectomy before and 2, 4, 12, 24, 48, and 64 hr (n = 5/time point) after PG injection. ACE mRNA expression (RT‐PCR) increased continuously and peaked at 12, 24 hr; ECE‐1 (endothelin converting enzyme) peaked at 12 hr, and both peptides in tissue (Ang II and ET‐1) increased significantly and peaked at 24 hr. The expression of receptors for Ang II (AT1R and AT2R) did not change in contrast to ET receptors (ETR‐A and ETR‐B), which were up‐regulated. Localization in tissue revealed very weak staining for Ang II and ET‐1 before PG application followed by a clear increase of staining predominantly in large luteal cells, but also in endothelial cells. In two experiments, the attempt was made to block ACE by the antagonist captopril with two different doses. In both experiments with captopril, progesterone levels were not significantly different from controls. Ang II alone seems to be not essential for functional luteolysis in bovine system. In conclusion, the results suggest that both Ang II and ET‐1 are in parallel up‐regulated during luteal regression and may act as vasoconstrictors during functional luteolysis, but also as apoptosis inducer during functional/structural luteolysis. Mol. Reprod. Dev. 65: 57–66, 2003. © 2003 Wiley‐Liss, Inc.
The association of benign prostatic hyperplasia and cancer of the prostate

There are a number of similarities between benign prostatic hyperplasia (BPH) and cancer. Both display a parallel increase in prevalence with patient age according to autopsy studies (86.2% and 43.6%, respectively, by the ninth decade), although cancer lags by 15–20 years. Both require androgens for growth and development, and both respond to antiandrogen treatment regimens. Most cancers arise in prostates with concomitant BPH (83.3%), and cancer is found incidentally in a significant number of transurethral prostatectomy (TURP) specimens (10%). The clinical incidence of cancer arising in patients with surgically treated BPH is approximately 3%. BPH may be related to a subset of prostate cancer which arises in the transition zone, perhaps in association with atypical adenomatous hyperplasia (AAH). It is important to exclude cancer in patients presenting with symptoms of bladder outlet obstruction presumably due to BPH. For such patients, we recommend digital rectal examination (DRE) and, at least in high‐risk patients, serum prostate specific antigen (PSA) determination. Transrectal ultrasound (TRUS) should be employed in patients with elevated PSA levels to determine the volume of the prostate, the relative contribution of BPH to volume, and the PSA density (ratio of PSA level to volume). Biopsy should be obtained from any area suspicious for cancer. Early detection and treatment of cancer when it is localized offers the greatest chance for cure.
Borrelia burgdorferi erp (ospE-Related) Gene Sequences Remain Stable during Mammalian Infection

ABSTRACT A number of studies have indicated that Borrelia burgdorferi erp genes need not vary during vertebrate infection. However, it was recently reported that a B. burgdorferi bacterium reisolated from an infected mouse evidenced mutation and recombination events in several erp genes. Reexamination of that reisolate indicates that the previously reported changes were no doubt artifacts of the PCR processes originally used to clone those DNAs. Thus, no evidence has been found of erp gene variation during mammalian infection.
A new design of a unipolar hip endoprosthesis focused on the best quality of life of the patients during the postoperative period

As a rule, unipolar hip endoprostheses are applied for the rehabilitation of elderly patients with hip joint functions recovery required. After surgery, patients often experience discomfort produced by forces' redistribution in driving muscles while walking. Such redistribution takes place because of the thigh mass increase around the hip joint. Explanation of a newly-designed unipolar endoprosthesis with a hollow head and its functioning analysis compared with conventional designs are provided in this paper. Data results of endoprosthesis clinical trials are provided. The design is human-centered, so its application in medical practices allows for improvement of patient life during the postoperative period.
Statistical motor unit number estimation: From theory to practice

Statistical motor unit number estimation (MUNE) is one of several experimental techniques used to estimate the number of lower motor neurons innervating a given muscle. All are fairly reproducible and have been applied successfully in monitoring neurogenic disease progression. Quantitating the number of lower motor neurons is important, since the compound muscle action potential (CMAP) and strength may not change as rapidly over time due to the confounding effect of reinnervation. MUNE techniques differ in the way they obtain samples of surface‐recorded motor unit potentials (SMUP). Statistical MUNE is based on Poisson statistics, uses surface stimulation, and is useful in testing distal, superficial nerves. This review focuses on the theory behind the development of the technique, critiques the publications resulting from applying the technique in control and disease subjects, and discusses the future developments needed for clinical utility. Muscle Nerve 28: 263–272, 2003
The jiaoyao 1 Mutant Is an Allele of korrigan 1 That Abolishes

Lei Lei,a Tian Zhang,b,1 Richard Strasser,c,1 Christopher M. Lee,d Martine Gonneau,e Lukas Mach,c Samantha Vernhettes,c Seong H. Kim,d Daniel Cosgrove,b Shundai Li,a and Ying Gua,2 a Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802 bDepartment of Biology, Pennsylvania State University, University Park, Pennsylvania 16802 cDepartment of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, A-1190 Vienna, Austria d Chemical Engineering and Materials Research Institute, Pennsylvania State University, University Park, Pennsylvania 16802 e Institut Jean-Pierre Bourgin, Unité Mixte de Recherche 1318 INRA-AgroParisTech, 78026 Versailles, France