Miracle-dz/UniFAR-FTUs huggingface dataset:
Inherent Details of Self-Regulated Learning Include Student Perceptions

Winne' s (1995) thoughtful and proactive article stressed the role of metacognitive processes in self-regulated learning. Although metacognition and forms of knowledge are important, they provide an incomplete picture of the processes involved in self-regulation. Theoretical and empirical evidence support the inclusion of student perceptions and motivational processes as integral components of self-regulation. Research incorporating the operation of student knowledge and perceptions will make a significant contribution to the self-regulation literature and have important implications for instruction.
Terrestrial Laser Scanning for the digital protection of historical architecture

Recently, Terrestrial Laser Scanning (TLS) is widely applied in protecting and archiving historical architecture because it can obtain accurate and dense 3D points. Simultaneously, advanced database management platform supports spatial and attribute data, it is essential to historical architecture representation and data dissemination. So, it is possible to describe historical architecture thanks to the combination of database and TLS technology. In this work, we described detailedly field data acquisition and data process, provided the method that the registration of multi-station point clouds by the corresponding targets which is with common reference coordinate and TLS local coordinate. In addition, the database is adopted to achieve data management and conservation because mass spatial data and attribute data including point clouds data, control points data, image data, texture data, and other text files were obtained in the experiment. The result shows that TLS and above-mentioned methods in the digital protection of historic architecture are feasible.
Spatiotopic perceptual learning mediated by retinotopic processing and attentional remapping

Visual processing takes place in both retinotopic and spatiotopic frames of reference. Whereas visual perceptual learning is usually specific to the trained retinotopic location, our recent study has shown spatiotopic specificity of learning in motion direction discrimination. To explore the mechanisms underlying spatiotopic processing and learning, and to examine whether similar mechanisms also exist in visual form processing, we trained human subjects to discriminate an orientation difference between two successively displayed stimuli, with a gaze shift in between to manipulate their positional relation in the spatiotopic frame of reference without changing their retinal locations. Training resulted in better orientation discriminability for the trained than for the untrained spatial relation of the two stimuli. This learning‐induced spatiotopic preference was seen only at the trained retinal location and orientation, suggesting experience‐dependent spatiotopic form processing directly based on a retinotopic map. Moreover, a similar but weaker learning‐induced spatiotopic preference was still present even if the first stimulus was rendered irrelevant to the orientation discrimination task by having the subjects judge the orientation of the second stimulus relative to its mean orientation in a block of trials. However, if the first stimulus was absent, and thus no attention was captured before the gaze shift, the learning produced no significant spatiotopic preference, suggesting an important role of attentional remapping in spatiotopic processing and learning. Taken together, our results suggest that spatiotopic visual representation can be mediated by interactions between retinotopic processing and attentional remapping, and can be modified by perceptual training.
University of Groningen The Hansenula polymorpha peroxisomal targeting signal 1 receptor , Pex 5 p , functions as a tetramer

We have studied Hansenula polymorpha Pex5p and Pex20p, peroxins involved in peroxisomal matrix protein import. In vitro binding experiments suggested that H. polymorpha Pex5p and Pex20p physically interact. We used single particle electron microscopy (EM) to analyze the structure of purified Pex5p and its possible association with Pex20p. Upon addition of Pex20p, a multimeric Pex20p complex was observed to be associated to the periphery of the Pex5p tetramer. In this Pex5p–Pex20p complex, the conformation of tetrameric Pex5p had changed from a closed conformation with a diameter of 115 Å into an open conformation of 134 Å. EM also indicated that the Pex5p–Pex20p complex was capable to bind native, folded catalase, a peroxisomal PTS1 protein. This suggests that the Pex5p–Pex20p complex may be functional as receptor complex. 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Members of the Plag gene family are expressed in complementary and overlapping regions in the developing murine nervous system

In the developing nervous system, cell fate specification and proliferation are tightly coupled events, ensuring the coordinated generation of the appropriate numbers and correct types of neuronal and glial cells. While it has become clear that tumor suppressor genes and oncogenes are key regulators of cell division in tumor cells, their role in normal cellular and developmental processes is less well understood. Here we present a comparative analysis of the expression profiles of the three members of the pleiomorphic adenoma gene (Plag) family, which encode zinc finger transcription factors previously characterized as tumor suppressors (Zac1) or oncogenes (Plag1, Plag‐l2). We focused our analysis on the developing nervous system of mouse where we found that the Plag genes were expressed in both unique and overlapping patterns in the central and peripheral nervous systems, and in olfactory and neuroendocrine lineages. Based on their patterns of expression, we suggest that members of the Plag gene family might control cell fate and proliferation decisions in the developing nervous system and propose that deciphering these functions will help to explain why their inappropriate inactivation/activation leads to tumor formation. Developmental Dynamics 234:772–782, 2005. © 2005 Wiley‐Liss, Inc.
The Influence of Midday Naps and Relaxation-Hypnosis on Declarative and Procedural Memory Performance

T are a number of different theories why humans are sleeping ranging from energy conservation to brain detoxification (1). For the last 15 years a growing number of studies examined memory consolidation as one possible function of human sleep. Memory consolidation is a process of reactivation and incorporation of afore labile memory traces into a more permanent form embedded in long-term-memory (2). Early findings (3) already showed a diminished forgetting rate for nonsense syllables after intervals of sleep compared to intervals of wakefulness. The authors concluded “that forgetting is not so much a matter of the decay of old impressions and associations as it is a matter of interference, inhibition, or obliteration of the old by the new. ” (Jenkins & Dallenbach, 1924, p. 612). By now there is near consensus that sleep improves human memory performance when compared to periods of wakefulness. Many studies have shown this quite robust effect called the sleep-memory-effect (4). The vast majority of these experiments compared a whole night of sleep with an equivalent interval The Influence of Midday Naps and Relaxation-Hypnosis on Declarative and Procedural Memory Performance
A simplified approach for evaluation of hepatic drugoxidizing activity with a simultaneous determination of caffeine and trimethadione and their demethylated metabolites in rats with a selective cytochrome P‐450 inducer

We determined the blood concentrations of caffeine (CA) and its three primary dimethylxanthine metabolites: theobromine (TB), paraxanthine (PX), and theophylline (TP), and trimethadione (TMO) and its demethylated metabolite dimethadione (DMO) after the simultaneous administration of CA (10 mg kg−1) and TMO (4 mg kg−1) to rats pretreated with phenobarbital (PB: 40 and 80 mg kg−1 i.p. daily for 3 days) and 3‐methylcholanthrene (MC: 10 and 20 mg kg−1 i.p. daily for 2 days). After the oral administration of CA and TMO, the PB‐pretreated rats showed a significant increase in TMO metabolism, whereas the CA metabolism was greatly accelerated in rats pretreated with MC.
Statistics on Temporal Changes of Sparse Coding Coefficients in Spatial Pyramids for Human Action Recognition

SUMMARY Traditional sparse representation-based methods for human action recognition usually pool over the entire video to form the ﬁ-nal feature representation, neglecting any spatio-temporal information of features. To employ spatio-temporal information, we present a novel histogram representation obtained by statistics on temporal changes of sparse coding coe ﬃ cients frame by frame in the spatial pyramids constructed from videos. The histograms are further fed into a support vector machine with a spatial pyramid matching kernel for ﬁnal action classiﬁcation. We validate our method on two benchmarks, KTH and UCF Sports, and experiment results show the e ﬀ ectiveness of our method in human action recognition.
A stereotaxic atlas of the brain of the cynomolgus monkey (Macaca fascicularis)

Outline drawings of representative frontal sections of the Macaca fascicularis brain are presented in stereotaxic coordinates. The levels extend from the rostral tip of the neostriatum to the posterior end of the deep cerebellar nuclei. The illustrations are based on photographs of unstained frozen sections of three formalin‐fixed brains in which stainless steel needles were inserted to mark the horizontal zero and several anteroposterior positions. The sections were not stained in order to prevent shrinkage. Stereotaxic measurements were taken in situ of the highest points on the cortical surface, the position of the central and lunate sulcus, and of certain landmarks at the base of the cranium in a large number of monkeys. These data along with brain dimensions and the weight of animals are displayed in tables to indicate individual variations and to aid investigators in determining the best stereotaxic coordinates for a given structure. It is recommended that the cortical point of entry for an electrode or needle be routinely noted and be compared to the parameters in the atlas to compensate for deviations in the horizontal plane.
Loss of three major auto phosphorylation sites in the EGF receptor does not block the mitogenic action of EGF

The EGF receptor cDNA has been transfected into receptor‐negative Chinese hamster ovary (CHO) cells. A mutant cell line (CHO 11) was isolated that expresses a receptor of lower molecular weight than the EGF receptor from A431 cells (150,000 daltons compared to 170,000 daltons) and which appeared as a doublet on SDS‐PAGE. By digestion of the receptor with endoglycosidase F it was shown that an altered pattern of glycosylation could not account for the smaller size of the protein, although it could explain the appearance of the CHO 11 receptor as a doublet protein. A deletion was located to the transfected cDNA and shown to involve the removal of coding sequences for the most C‐terminal 20,000 daltons of the EGF receptor, which contains the three major autophosphoryation sites. Despite the loss of these sites the EGF receptor from CHO 11 cells binds EGF, demonstrates protein tyrosine kinase activity in response to EGF, and transduces a mitogenic signal. The CHO 11 receptor protein is still autophosphorylated on alternative tyrosine residues. We conclude that phosphorylation of the three tyrosines (P1, P2, and P3) in the C‐terminal domain of the receptor is not required for signal transduction by the EGF receptor in these cells.
Analyzing recommender systems and applying a location based approach using tagging

In the past few decades, due to the increase in the accessibility of the world wide web, data is being generated on a large scale, everyday. When the end user tries to access this data, the available variety of options make it a difficult task to choose amongst various products. In order to simplify this process, Recommender Systems were designed. In this paper, we have analyzed how these Recommender Systems came into existence, their functionalities and how this idea is shaping the world of data science. We analyzed few of the prominent techniques used, such as Content based, Collaborative and Hybrid recommendations. Tagging has become an important tool in Data Science, which can be used to collect implicit data of users and generate recommendations. The paper proposes such an approach which is motivated by observing that many effective recommendations can be generated by analyzing the tagging done by the users. Most of the work is based on the feedback from users having a tendency to use the tagging feature, mostly on social media platforms. The tag based recommendations are also generated by taking into consideration a pattern between users who use location-based services. Counting in the similarities between their Internet browsing preferences and the tag information collected, accurate recommendations can be suggested to the users.
ION EXCHANGE RESINS AND APPLICATIONS IN PHARMACEUTICAL TECHNOLOGY

Ion exchange resins (IER) are cross-linked, water i nsoluble polymers carrying ionizable functional groups on their repeating positions. They are consi dered as safe materials due to their insoluble and nonabsorbable nature. This advantage made IER subje ct of several research in different areas of pharmaceutical technology such as oral sustained re l as , taste masking, rapid dissolution, stability enhancement and also they are used for their therap eutic activity since the middle of 20 th century. This review discussed the general properties of IER and their novel applications in the area of pharmaceutical technology.
Formation tracking control and formation stabilization control of multiple nonholonomic mobile robots

Formation tracking control problem and formation stabilization problem for multiple nonholonomic mobile robots are considered in this paper. Through introducing a virtual nonholonomic robot, the formation control problem is transformed into a tracking problem between the virtual robot and the leader. According to different motions of the leader robot, formation tracking and formation stabilization problem can be manipulated in a same framework. Theories from nonautonomous cascaded systems are involved to simplify the controller synthesis after carefully studying the structure of the error dynamics systems and global exponential controllers are obtained for these control problems in the end. Simulation results using Matlab illustrated the effectiveness of solving the formation control problems using methodologies presented in this paper.
Browsing gene banks for Fe2S2 ferredoxins and structural modeling of 88 plant‐type sequences: An analysis of fold and function

One‐hundred‐and‐seventy‐nine sequences of Fe2S2 ferredoxins and ferredoxin precursors were identified in and retrieved from currently available protein and cDNA databases. On the basis of their cluster‐binding patterns, these sequences were divided into three groups: those containing the CX4CX2CXnC pattern (plant‐type ferredoxins), those with the CX5CX2CXnC pattern (adrenodoxins), and those with a different pattern. These three groups contain, respectively, 139, 36, and 4 sequences. After excluding ferredoxin precursors in the first group, two subgroups were identified, again based on their cluster‐binding patterns: 88 sequences had the CX4CX2CX29C pattern, and 29 had the CX4CX2CXmC (m ≠ 29) pattern. The structures of the 88 ferredoxins with the CX4CX2CX29C pattern were modeled based on the available experimental structures of nine proteins within this same group. The modeling procedure was tested by building structural models for the ferredoxins with known structures. The models resulted, on average, in being within 1 Å of the backbone root‐mean‐square deviation from the corresponding experimental structures. In addition, these structural models were shown to be of high quality by using assessment procedures based on energetic and stereochemical parameters. Thus, these models formed a reliable structural database for this group of ferredoxins, which is meaningful within the framework of current structural genomics efforts. From the analysis of the structural database generated it was observed that the secondary structural elements and the overall three‐dimensional structures are maintained throughout the superfamily. In particular, the residues in the hydrophobic core of the protein were found to be either absolutely conserved or conservatively substituted. In addition, certain solvent‐accessible charged groups, as well as hydrophobic groups, were found to be conserved to the same degree as the core residues. The patterns of conservation of exposed residues identified the regions of the protein that are critical for its function in electron transfer. An extensive analysis of protein—protein interactions is now possible. Some conserved interactions between residues have been identified and related to structural and/or functional features. All this information could not be obtained from the analyses of the primary sequences alone. Finally, the analysis of the sequences of the related subgroup featuring the CX4CX2CXmC (m ≠ 29) cluster‐binding pattern in the light of the structural and functional insights provided by the inspection of the mentioned structural database affords some hints on the functional features of ferredoxins belonging to this subgroup. Proteins 2002;46:110–127. © 2001 Wiley‐Liss, Inc.
Manufacturing Execution Systems und Operational Business Intelligence

Manufacturing Execution Systems (MES) und Operational Business Intelligence (OpBI) analysieren und koordinieren betriebliche Abläufe in unterschiedlichen Segmenten der Wertschöpfungskette eines Unternehmens. Dies birgt die Gefahr, dass eine Verinselung der Infrastruktur innerhalb der operativen Entscheidungsunterstützung erfolgt. Daher ist das Ziel der Forschung, inwieweit eine gemeinsame Betrachtung von OpBI und MES ein Potenzial im Kontext einer unternehmensweiten Steuerung und Analyse von operativen Prozessen birgt, sodass Unternehmen sich flexibel an sich wandelnde Rahmenbedingungen anpassen können. In diesem Beitrag werden die Forschungsidee und ein methodisches Raster zur Zusammenführung von MES und OpBI in einer operativen Integrationsplattform skizziert. Erste Arbeitsergebnisse einer literaturbasierten Begriffsklassifikation motivieren eine intensivere Auseinandersetzung des Forschungsansatzes, um Erkenntnisse für eine prozessorientierte, BI-gestützte Entscheidungsunterstützung zu gewinnen.
p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex

The nuclear exosome targeting complex (NEXT) directs a major 3′–5′ exonuclease, the RNA exosome, for degradation of nuclear noncoding (nc) RNAs. We identified the RNA-binding component of the NEXT complex, RBM7, as a substrate of p38MAPK/MK2-mediated phosphorylation at residue S136. As a result of this phosphorylation, RBM7 displays a strongly decreased RNA-binding capacity, while inhibition of p38MAPK or mutation of S136A in RBM7 increases its RNA association. Interestingly, promoter-upstream transcripts (PROMPTs), such as proRBM39, proEXT1, proDNAJB4, accumulated upon stress stimulation in a p38MAPK/MK2-dependent manner, a process inhibited by overexpression of RBM7S136A. While there are no stress-dependent changes in RNA-polymerase II (RNAPII) occupation of PROMPT regions representing unchanged transcription, stability of PROMPTs is increased. Hence, we propose that phosphorylation of RBM7 by the p38MAPK/MK2 axis increases nuclear ncRNA stability by blocking their RBM7-binding and subsequent RNA exosome targeting to allow stress-dependent modulations of the noncoding transcriptome.
Xeno-Free Strategies for Safe Human Mesenchymal Stem/Stromal Cell Expansion: Supplements and Coatings

Human mesenchymal stem/stromal cells (hMSCs) have generated great interest in regenerative medicine mainly due to their multidifferentiation potential and immunomodulatory role. Although hMSC can be obtained from different tissues, the number of available cells is always low for clinical applications, thus requiring in vitro expansion. Most of the current protocols for hMSC expansion make use of fetal bovine serum (FBS) as a nutrient-rich supplement. However, regulatory guidelines encourage novel xeno-free alternatives to define safer and standardized protocols for hMSC expansion that preserve their intrinsic therapeutic potential. Since hMSCs are adherent cells, the attachment surface and cell-adhesive components also play a crucial role on their successful expansion. This review focuses on the advantages/disadvantages of FBS-free media and surfaces/coatings that avoid the use of animal serum, overcoming ethical issues and improving the expansion of hMSC for clinical applications in a safe and reproducible way.
Plasma fibrinogen level, BMI and lipid profile in type 2 diabetes mellitus with hypertension

Diabetic hypertensives have higher cardiovascular morbidity and mortality than general population. Various risk factors like age, BMI, hypertension, smoking, dyslipidemia, etc. have been extensively studied, but still these together cannot explain increased cardiovascular morbidity and mortality in diabetes. Several studies have shown that fibrinogen is a powerful independent risk factor for cardiovascular disease. In the present study fibrinogen levels of 50 diabetic hypertensive subjects were estimated and its correlations with various parameters like BMI and lipid profile were studied. Higher plasma fibrinogen levels were found in diabetic hypertensives (449.06  131.26). There was a significantly positive correlation between plasma fibrinogen and BMI (p < 0.05). There was a significantly positive correlation between BMI and total cholesterol levels (p < 0.05). Diabetic hypertensives have higher fibrinogens levels, which were related to BMI and total cholesterol level in a statistically significant manner.
Small Animal X-ray Computed Tomography

X-ray computed tomography (CT) systems with high resolution (also known as micro-CT systems) have been developed over the last two decades and have been used with great success in small animal studies. A micro-CT scanner is based on the same underlying physical principle as a clinical CT scanner, but it is designed for higher-resolution imaging. It produces three-dimensional (3D) tomographic data at microscopic resolution (voxel size ≤100 μm3) by taking hundreds of 2D projections from multiple angles around the animal (Holdsworth and Thornton 2002). The X-ray source produces a cone beam, which is projected through the specimen with the resultant radiographic density of the specimen projected onto a 2D detector. The projections are used by a reconstruction algorithm that is generally based on the filtered backprojection (Kak and Slaney 1988) (see Figure 36.1). The resultant micro-CT scan is a 3D matrix of voxels with values proportional to the mean linear attenuation coefficient of the material within each voxel; the 3D matrix can be sliced in any orientation to reveal different views of the anatomy. There are many commercially available micro-CT scanners for in vivo and ex vivo imaging. In vivo scanners are used to scan live animals (mostly mice and rats), while ex vivo scanners are used for imaging dead specimens and materials, such as bone and scaffolds. There are major differences between the two types of scanners. With in vivo micro-CT instruments, the animal remains alive and available for longitudinal studies, thus reducing the number CONTENTS