Miracle-dz/UniFAR-FTUs huggingface dataset:
Modelling Simulation and Performance Analysis for Footwear Manufacturing System

In today's dynamic world economy, corporations are often trying to reinforce themselves as much as possible in all facets of industry competitiveness. This demand for an optimized production system which enhances the company's overall productivity. The survival of every business in today's dynamic environment depends primarily on response time, cost of production, market price, and manufacturing stability. Only by managing the complexity of any manufacturing line will they accomplish these things. The assembly of any product or machine is highly complex, affecting the production time of assembly due to the order of sequence. In order to obtain the optimal line in an operation, it should be very necessary during operation to schedule to make clear which part should come in what order and what tasks will be performed together, how many work stations are needed. The number of workstations, whose task is the previous workstation, and what is in sequence will affect the time to complete the task, as well as the usage of resources, i.e. whether manpower or machines. These things motivated continuous research in modeling and performance evaluation of manufacturing systems. In parallel, different simulation software plays a significant role in developing a model of a real system and performing experiments with this model in order to explain the system's actions and test different operating or production system techniques and scenarios. As the majority of consumable and non-consumable goods are made on an assembly line basis, it is necessary to solve the line balancing issue every day. One type of good that is manufactured on the assembly line method is footwear. This paper deals with the modeling, simulation and performance assessment of assembly line balance of Jamaica-Ok footwear manufacturing company. This paper is specifically concerned with the modeling and simulation of the single assembly line within the manufacturing department: Stitching assembly line. In order to do so, Arena modeling software is used to simulate and calculate the performance of the assembly line's current production processes. Finally, the simulation result shows that the waiting time of each station of the stitching line is calculated among the longest waiting and suggested a way to avoid the issue of waiting time via the development mechanism.
Estrogen Replacement Therapy for Treatment of Mild to Moderate Alzheimer DiseaseA Randomized Controlled Trial

ALZHEIMER DISEASE (AD) AFfects more than 4 million Americans and is one of the most frequent obstacles to healthy aging in this country. Women appear to be at higher risk for developing AD, only in part due to increased longevity. Because women with AD also live longer than men with AD, there are approximately twice as many women as men in the population with this disorder. It has been suggested that the abrupt decline of estrogen production in postmenopausal women may be associated with a vulnerability of women to develop AD. Men, in contrast, have an intrinsic supply of estroAuthor Affiliations: University of California, Irvine (Drs Mulnard and Cotman); Johns Hopkins University, Baltimore, Md (Dr Kawas); Yale University, New Haven, Conn (Dr van Dyck); Columbia University, New York, NY (Dr Sano); Baylor College of Medicine, Houston, Tex (Dr Doody); Case Western Reserve University, Cleveland, Ohio (Dr Koss); University of South Florida, Tampa (Dr Pfeiffer); and the University of California, San Diego (Drs Jin, Gamst, Grundman, Thomas, and Thal). Members of the Alzheimer’s Disease Cooperative Study are listed at the end of this article. Financial Disclosure: Dr Sano participates in an unrestricted educational grant to Columbia University from Wyeth Ayerst Pharmaceuticals, the manufacturer of the estrogen replacement therapy drug used in this study. Corresponding Author and Reprints: Ruth A. Mulnard, RN, DNSc, Institute for Brain Aging and Dementia, University of California, Irvine, 1113 Gillespie Neuroscience Research Facility, Irvine, CA 926974540 (e-mail: ramulnar@uci.edu). Context Several reports from small clinical trials have suggested that estrogen replacement therapy may be useful for the treatment of Alzheimer disease (AD) in women.
Ancient DNA revea旭s the timing and persistence of organe旭旭ar genetic bott旭enecks over ザpグググ years of sunf旭ower domestication and improvement

eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse This article is distributed under the terms of the Creative Commons Attribution (CC BY) licence. This licence allows you to distribute, remix, tweak, and build upon the work, even commercially, as long as you credit the authors for the original work. More information and the full terms of the licence here: https://creativecommons.org/licenses/
Imperfect Information Game – A Review

Card games are interesting for many reasons besides their connection with gambling. Among the huge variety of games, the researchers focus on those in which cards dealt randomly at the beginning of the game, with each player receiving a hand of cards that is not visible to the other players. Bridge is being a game of imperfect information, it is well defined and decision making game. The imperfect information games are contrasted with the perfect information game, where as the players are not having the complete knowledge of the game, where one player does not know exactly what cards the opponent hold. The Game of bridge provides lot of chance to conduct research to the researchers, because many components that constitutes the game. Hence researchers have much interested in this field especially in Double Dummy Bridge Problem (DDBP).
CONTRIBUIÇÕES AO CONTROLE CURRENT PROGRAMMED MODE (CPM) APLICADO A CONVERSORES CC-CC

Although very widespread in industry, the CPM control strategy applied to DC-DC converters lack scientific discussions and a complete design methodology for correct implementation. In this context, this paper contribute with a methodology f modelling C-DC Buck and Forward converters besides presenting the CPM control design to aplly in these circuits. The challenges faced during modelling and control of these structures are also presented herein. The modelling considers the subharmonic frequencies and the magnetization current as an external compensation ramp in the control system. The final modelling of the Forward converter was validated by simulation in time and the frequency domains. Simulated and experimental results to validate the control strategy are presented for the following circuit parameters: 400 V 24 V of input-to-output voltage, 100 kHz of switching frequency and 200 W of output power.
Evaluation of Analgesic and Anti-Inflammatory Activities of hydro-alcoholic leaf extract of Hypericum revolutum in Mice

Background: Despite the progress that has been made in the past for the development of pain and inflammation therapy, there is a need for effective and potent medicinal agent with lower side effects. The aim of this study was to evaluate the analgesic and anti-inflammatory activities of 80% methanol leaf extract of Hypericum revolutum in mice. Method: After extraction of the crude using 80% methanol, Hypericum revolutum extract was evaluated for analgesic and anti-inflammatory activity in hot plate test, acetic-acid induced writhing and carrageenan induced paw edema models. Extract was evaluated at 100, 200 and 400 mg/kg doses. The reference control groups were treated with morphine 5mg/kg or indomethacin 10mg/kg while vehicle, distilled water (10 ml/kg), treated animals were grouped as negative controls. Result: In the hot plate method, all doses of the extract and the standard drug morphine significantly prolonged the latency time in the hot plate method (p<0.05 or p<0.01 or p<0.001) when compared to the negative control throughout the observation time. Greater increase in latency was observed at the 120 minute and greater on the other time intervals with 200mg/kg of the extract with a significant value (p<0.001). Similarly, all test doses of the extract significantly (p<0.05) reduced the acetic acid induced writhing in mice. The extract of HR produced a significant analgesic activity with 62.4, 47.1 and 55.3% inhibition of number of writhing at 100, 200 and 400 mg/kg dose levels, respectively although the inhibition was greater for the standard. Moreover, for carrageenan induced paw edema test treatment with the extract (100, 200, and 400mg/kg) and the standard have shown significance (p<0.01 or p<0.001) suppression of edema at all-time points as compared to controls. Conclusion: The 80% hydro-methanolic extract of H. revolutum exhibited analgesic and anti-inflammatory effects in mice models.
Application of Text-Based Design Guidelines to Building Permit Review Communication -Part I: The Influence of Field of Experience

This series of studies investigated how ″Field of Experience,″ ″Semantic interpretation,″ and ″Group Communication Pressure″ influence the application of text-based design guidelines to graphic-based building designs, and cause communication failures during building permit review communication. In this first part, authors invited 16 experts in building design and divided them into four groups with similar fields of experience to assess design indicators by using the Fuzzy Delphi Method. The results showed that among various professionals, their varying fields of experienced caused design indicators to be assessed discrepantly. Authors plan to continue to explore how text-based design guidelines negatively influence communication effectiveness through semantic differences and group communication pressure and how to enhance communication effectiveness in the building design review processes.
Comparison of ARIMA and ARIMA/GARCH Models in EVN Traffic Prediction

- This paper focuses on building statistical models to capture and forecast the traffic of mobile communication network in Vietnam. Following Box-Jenkins method, a multiplicative seasonal ARIMA model is constructed to represent the mean component using the past values of traffic, a GARCH model is then incorporated to represent its volatility. The traffic is collected from EVN Telecom mobile communication network. The numerical result comparisons show that the multiplicative seasonal ARIMA/GARCH model built in this paper gives a better estimate when dealing with volatility clustering in the data series. However, in short-term prediction where the volatility has an insignificant influence, the achieved ARIMA model also can be considered as a good model to capture well the characteristics of EVN traffic series and gives reasonable forecasting results.
SPR E AD IN G OF A SATU RATIO N FRONT OF HETEROGENEOUS CH EM ICAL REACTIO N THROUGH AN AEROSOL CLOUD

A cloud of aerosol particles sediments in air containing reactants. On the basis of a macroscopic chemical and mass transfer model founded on the kinetic theory of heterogeneous reactions we analyzed the spreading of chemical reaction through the cloud of aerosol particles. In this paper we considered a binary reaction with one volatile and one non-volatile product at the surface of aerosol particles. If the finite saturation capacity with respect to non-volatile reaction product accumulated in the droplet is taken into account, the eventual deceleration of the reaction results in the propagation of a saturation front. The spatial distributions of concentrations and their evolution in time are determined, as well as the velocity of saturation front.
A review on the features and technologies for energy efficiency of smart grid

In today's world striving for efficiency in every sector, especially power generation and distribution, smart grids emerge as the solution for efficiently meeting the increasing demand. They adjust themselves to optimally deliver energy at the lowest cost and highest quality possible. The grid successfully makes use of renewable energy resources, electric vehicles, and smart pricing techniques in its attempt to achieve energy efficiency. It also promotes a greener environment by striving to reduce greenhouse gas emissions. Information communication technology (ICT) helps the grid in collecting consumption data from the consumers and in sharing tariff information. ICT also helps to gather information about the status of the grid with regard to aspects like power quality, faults etc. The purpose of this paper is to review recent literature with a view to comprehensively present the technologies employed in the smart grid for achieving energy efficiency and the challenges involved therein.
Effect of Sericin in [HA/Bioplastic] Composite Composed by 2k Factorial Design Method on Solidification Time and Tensile Strength

Synthetic hydroxyapatite has been attractive ceramic for a decade as main material of bonegraft. However, in powder form it was difficult to shape into certain geometry due to its brittleness characteristic. For this, composing it with another biomaterial as a matrix in a proper composition can be a challenging. In the present work, bioplastic (B) made of cassava starch was selected as a matrix material and silk sericin (SS) extracted from B.mori cocoon was added. Hydroxyapatite was obtained from bovine hydroxyapatite (H). The composite was prepared by mixing of H/B with ratio of 20/80 and 80/20 and sericin of 8% and 16%w/w was blended to form pasta. It was then casted layer by layer (0.1mm and 0.5mm thick) into mould with size of 6mm diameter and 3mm deep. The composite component was composed by utilizing 2 Factorial Design Method and selected the highest of diametral tensile strength (DTS). ANOVA was performed to evaluate hypothesis H0 and H1 based upon the sources and two regression models of Y=f(X, ) that represented solidification time and tensile strength were developed. The result of solidification time model reveals that composite [H80/B20/S16] with 0.1mm layer thickness had the shortest time of 106.36sec and the highest DTS of 3.46MPa. These results were slightly lower than that obtained by experiment i.e. 107sec and 3.88MPa, respectively. Additional sericin twice for this composite gains more significant effect in improving DTS and solidification time compared to that of giving hydroxyapatite. Keyword-bovine hydroxyapatite, bioplastic, sericin, solidification time, diametral tensile strength
Ageing in organizations A view of HR professionals on the positioning of mature managers and adoption of age management practices

Purpose – This paper aims to show which factors influence the perception of human resources professionals about managers over 50 years old and which factors guide the age management practices adopted in the surveyed companies. Design/methodology/approach – To this end, a survey was conducted with 140 companies accessed from a database of a human resources association. Through the answers obtained through the online questionnaire, an exploratory factor analysis wasmade with the aid of Software R. Findings – Thus, it was possible to identify four factors that explain the work posture of professionals 50 years of age and older (company expectations, performance, morality and knowledge and professionalism) and three factors that guide the adoption of age management practices in organizations (recruitment & selection and integration, retention and continuity in the company, adaptation to the needs). Originality/value – The results suggest that, even considering the high performance of older managers, perceived by HR professionals, the adoption of age management practices is still insufficient, making it difficult for these professionals to enter and remain in organizations. Moreover, it can be inferred that such posture indicates biases of discrimination and age stereotypes.
Characterization of conformational ensemble of C-terminally truncated -synuclein in aqueous solution by atomistic molecular dynamics simulations

-Synuclein is an intrinsically disordered protein, whose aggregation into amyloid fibril is involved in the pathology of Parkinson’s disease. C-terminally truncated -synuclein variants, which are naturally generated from the full-length -synuclein, are enriched in the pathological -synuclein aggregates and known to significantly enhance the aggregation process. In this work, we have performed extensive Gaussian accelerated molecular dynamics simulations (3.8 s in total) to characterize the equilibrium conformational ensemble of a physiologically relevant C-terminally truncated -synuclein monomer, AS(1-103), in aqueous solution. The nearly flat free-energy landscape of AS(1-103) suggests coexistence of mult iple distinct conformational states, including disordered conformations and conformations with transient secondary and tertiary structures. We found that the predominant conformation of AS(1-103) in aqueous solution exhibit enrichment of -sheet structure at different parts of the N-terminal and hydrophobic NAC domain, including the aggregation-prone NAC-core. We identified moderate intraand inter-domain interactions within the N-terminal and the NAC domain that enhance and stabilize the partially folded -sheet rich structures of AS(1-103) in solution. Such stable structural regions formed in the AS(1-103) ensemble, may serve as potential molecular signature that encodes the aggregation seed. The presented work enables characterization of conformational states of monomeric AS(1-103) in solution, and provide a plausible explanation for the experimentally determined enhanced aggregation propensity of C-terminally truncated variants of -synuclein in vivo.
between algal food and gut and gonad conditions in the Mediterranean sea urchin

A study was conducted on the population of Paracentrotus lividus (Lamarck, 1816) in a Mediterranean infralittoral bottom of southern of Spain to characterize the relationships between the macroalgal food ingested and the gut and gonad conditions of individuals. Over a full annual cycle (November 2008 to October 2009) composition of the gut content was analyzed monthly and seasonally, the gastrointestinal (GII), repletion (RI) and gonadosomatic (gonad) (GI) indices were calculated, and the stage of gonad maturity of the population was assessed. The GII and RI were found to be strongly correlated, so only the RI was con- sidered in the subsequent analysis. The prevalence of Phaeophyceae and local species of this macroalgal group in the gut content of the sea urchins throughout the year suggests that in conditions of abundant resources, with high levels of algal diversity and no effective limits on supply, brown algae are the main component of the natural diet of P. lividus . Comparison of the physiological indices and the algal fractions of gut content identified relationships throughout the year between RI, the stage of gonad maturity and GI. Specifically, these indices were found to be associated with the abundance of Rhodophyta ingested, although in different ways: GI was related to the consumption of fleshy (non-calcified) red algae and the RI, though less statistically significantly, to the consumption of calcified (articulate and encrusting). from comparison of the two (Spearman rank correlation test, r=+0.90, p<0.001).
Turbulence modelling techniques for aeroelastic problems: results and comments from the Second AIAA Aeroelastic Prediction Workshop

Purpose The quality of aeroelastic predictions strongly depends on the quality of aerodynamic predictions. At the boundary of a typical flight envelope, special flow conditions may arise, which challenge the conventional Reynolds-averaged Navier–Stokes (RANS) approach beyond reasonable limits. Design/methodology/approach Test Case 3 of the Second AIAA Aeroelastic Prediction Workshop is a representative test case, where the flow over a supercritical wing separates downstream of the shock waves and generates large turbulent lengthscales. Findings In this study, RANS predictions are compared to those obtained in this particular test case with the more sophisticated hybrid RANS–large eddy simulation (LES) approach, in particular with the Spalart–Allmaras–delayed detached eddy simulation model. Results are indeed closer to experimental data. Originality/value However, the costs associated with this approach are much higher. It is argued that adopting hybrid RANS–LES modelling is not a simple model switch.
The Study of Multilayer Graphene Membrane Performance in O2 Puri cation Process: Molecular Dynamics Simulation

We use molecular dynamics (MD) method to describe the atomic behavior of Graphene nanostructure for Oxygen molecules (O2) separation from Carbon dioxide (CO2) molecules. Technically, for the simulation of graphene-based membrane and O2-CO2 gas mixture, we used Tersoff and DREIDING force fields, respectively. The result of equilibrium process of these structures indicated the good stability of them. Physically, this behavior arises from the appropriate MD simulation settings. Furthermore, to describe the purification performance of graphene-based membrane, we report some physical parameters such as purification value, impurity rate, and permeability of membrane after atomic filtering process. Numerically, by defined membranes optimization, the purification value of them reach to 97.31%. Also, by using these atomic structures the CO2 impurity which passed from graphene-based membrane reach to zero value.
Cell-to-Cell Interactions and Signals Involved in the Reconstitution of Peripheral CD8 T(CM) and T(EM) Cell Pools

We here describe novel aspects of CD8 and CD4 T cell subset interactions that may be clinically relevant and provide new tools for regulating the reconstitution of the peripheral CD8 T cell pools in immune-deficient states. We show that the reconstitution capacity of transferred isolated naı̈ve CD8 T cells and their differentiation of effector functions is limited, but both dramatically increase upon the co-transfer of CD4 T cells. This helper effect is complex and determined by multiple factors. It was directly correlated to the number of helper cells, required the continuous presence of the CD4 T cells, dependent on host antigen-presenting cells (APCs) expressing CD40 and on the formation of CD4/CD8/APC cell clusters. By comparing the recovery of (CD44CD62L) TCM and (CD44 CD62L) TEM CD8 + T cells, we found that the accumulation of TCM and TEM subsets is differentially regulated. TCM-cell accumulation depended mainly on type I interferons, interleukin (IL)-6, and IL-15, but was independent of CD4 T-cell help. In contrast, TEM-cell expansion was mainly determined by CD4 + T-cell help and dependent on the expression of IL-2Rb by CD8 cells, on IL-2 produced by CD4 T-cells, on IL-15 and to a minor extent on IL-6. Citation: Zaragoza B, Evaristo C, Kissenpfennig A, Libri V, Malissen B, et al. (2011) Cell-to-Cell Interactions and Signals Involved in the Reconstitution of Peripheral CD8 TCM and TEM Cell Pools. PLoS ONE 6(3): e17423. doi:10.1371/journal.pone. 0017423 Editor: Jean Kanellopoulos, University Paris Sud, France Received November 15, 2010; Accepted February 4, 2011; Published March 14, 2011 Copyright: 2011 Zaragoza et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This work was supported by the European Research Council (ERC), Ligue Nationale Contre le Cancer, Association pour la Recherche Contre le Cancer (ARC), Agence Nationale de la Recherche Contre le SIDA (ANRS), Agence Nationale pour la Recherche (ANR), Association Française des Myopathies (AFM), Centre National de la Recherche Scientifique (CNRS) and the Institut Pasteur. BZ was supported by the MRT and ARC, France and ARMA by the FCT, Portugal. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist. * E-mail: antonio.freitas@pasteur.fr (AAF); afonsoalmeida@fm.ul. pt (ARMA) ¤a Current address: Centre for Infection and Immunity, Queen’s University of Belfast, Northern Ireland ¤b Current address: Institute for Molecular Medicine, Lisboa, Portugal