Miracle-dz/UniFAR-FTUs huggingface dataset:
Rotational intraperitoneal pressurized aerosol chemotherapy with paclitaxel and cisplatin: pharmacokinetics, tissue concentrations, and toxicities in a pig model

Objective We used paclitaxel and cisplatin, known to be effective in intraperitoneal chemotherapy, in a novel prototype of rotational intraperitoneal pressurized aerosol chemotherapy (RIPAC) and evaluated the pharmacokinetics, tissue concentrations, and toxicities in a pig model. Methods We developed RIPAC, including the nozzle with the conical pendulum motion, and used 10% of intravenous doses of paclitaxel and cisplatin. We used high-performance liquid chromatography followed by tandem mass spectrometry to analyze serum and tissue concentrations. We applied a non-compartment model to study pharmacokinetics to analyze the time-dependent serum concentrations measured before RIPAC to 48 hours. We evaluated the difference in tissue concentrations between twelve peritoneal regions by the modified peritoneal cancer index. For evaluating toxicities, we observed hepatic and renal function until 4 days after RIPAC. Results Six pigs underwent RIPAC using paclitaxel (n=3) and cisplatin (n=3). The peak serum concentration (Cmax) and the area under the curve were higher for cisplatin, while the time to the peak serum concentration (Tmax) was longer for paclitaxel. Moreover, the parietal peritoneum showed higher tissue concentrations than the visceral peritoneum, and the ratio of tissue to serum concentrations using Cmax was higher for paclitaxel (172.2–6,237.9) than for cisplatin (0.1–9.3). However, there were no renal and hepatic toxicities after RIPAC with paclitaxel or cisplatin. Conclusion Delayed absorption of paclitaxel sprayed by RIPAC into the peritoneum to the bloodstream may lead to higher tissue concentrations at different regions and lower serum concentrations than cisplatin.
Variations in Fatty Acids Affected Their Derivative Volatiles during Tieguanyin Tea Processing

Fatty acids (FAs) are important precursors of oolong tea volatile substances, and their famous derivatives have been shown to be the key aroma components. However, the relationship between fatty acids and their derivatives during oolong tea production remains unclear. In this study, fresh Tieguanyin leaves were manufactured into oolong tea and green tea (control), and fatty acids and fatty acid-derived volatiles (FADV) were extracted from processed samples by the sulfuric acid–methanol method and solvent-assisted flavor evaporation (SAFE), respectively. The results showed that unsaturated fatty acids were more abundant than saturated fatty acids in fresh leaves and decreased significantly during tea making. Relative to that in green tea, fatty acids showed larger variations in oolong tea, especially at the green-making stage. Unlike fatty acids, the FADV content first increased and then decreased. During oolong tea manufacture, FADV contents were significantly and negatively correlated with total fatty acids; during the green-making stage, methyl jasmonate (MeJA) content was significantly and negatively correlated with abundant fatty acids except steric acid. Our data suggest that the aroma quality of oolong tea can be improved by manipulating fatty acid transformation.
A review on magnetically assisted abrasive flow machining and abrasive material type

The development of fine surface finish with no defects is still a significant challenge for the present industry and the finishing operation in the manufacturing of the precision components is the major problem. It is difficult rather impossible to polish/finish the difficult-to-reach surfaces, internal surfaces, and complex geometries by existing finishing methods. Abrasive flow machining (AFM) is a well-established advanced finishing process that can meet the required finishing requirements. However, the main disadvantages of this process are the surface integrity with low surface finish and high machining times. Magnetically Assisted Abrasive flow machining (MAAFM) is one of the non-conventional machining techniques that can successfully handle these problems. This process was developed in the early 2000s as a technique for deburring, polishing, and radiusing tough to reach surfaces like complicated configurations and edges/boundaries by flowing a magnetic abrasive polymeric medium across them. Magnetic flux density (MFD), extrusion pressure, flow volume, abrasive type, grit size, number of process cycles, medium, and workpiece configuration are the principal machining parameters that control the surface finish characteristics. The medium extruded forward and backward between two vertically opposed hydraulic cylinders across transit created by the workpiece and tooling. Abrasion of workpiece takes place wherever the medium proceeds across the highly confining transit. The major elements of the MAAFM process are the machine, tooling, and the magnetic abrasives containing media. MAAFM has a wide scope of uses in industries including automotive, aviation, precision dies, medicinal, electronics. This article represents a review of current advancements in the area of the MAAFM process and the type of magnetic abrasive particles (MAPs) used.
Corporate governance, ownership structure, and cost Stickiness = : evidence from Egypt /

تهدف هذه الدراسة الى فحص ظاهرة مطاطية التكلفة والتأثير المحتمل لكلا من متغيرات حوكمة الشركات وهياكل الملكية المختلفة عليها في جمهورية مصر العربية في سبيل تحقيق ذلك قامت الدراسة بتطبيق اربع نماذج انحدار متعدد باستخدام طريقة المربعات الصغرى لتحليل سلوك تكاليف البضاعة المباعة لعدد مكون من 85 شركة مسجلة في البورصة المصرية في الفترة من عام 2009 الى عام 2013 وقد اظهرت النتائج ان تكاليف البضاعة المباعة تزيد بنسبة 1.1% عند زيادة الايرادات بنسبة 1% بينما تنخفض فقط بنسبة 0.95% عند انخفاض الايرادات بنسبة 1% الامر الذي يثبت مطاطية تكاليف البضاعة المباعة في البيئة المصرية بالإضافة الى ذلك فقد اظهرت النتائج ان قلة عدد اعضاء مجلس الادارة واستقلاليتهم ( في حالة قياسها بمقياس عدم الجمع بين منصبي رئيس مجلس الادارة والمدير التنفيذي ) تؤدي الي تخفيض السلوك المطاطي لتكاليف البضاعة المباعة . بينما يؤدي متغير استقلالية اعضاء مجلس الادارة ( في حالة قياسه بنسبة الاعضاء غير التنفيذين) الى زيادة السلوك المطاطي لتكلفة البضاعة المباعة. كما اظهرت النتائج ان كلا من هياكل ملكية الادارة , المؤسسات, والحكومة تخفض من السلوك المطاطي لتكاليف البضاعة المباعة في البيئة المصرية . تتمثل الاضافة العلمية لهذه الدراسة في انها تستكشف مدي تحقق السلوك المطاطي لتكاليف البضاعة المباعة في البيئة المصرية, بالإضافة الى انها تدرس اثر متغيرات الحوكمة على السلوك المطاطي لتكاليف البضاعة المباعة والذي لم يدرس من قبل في الدول النامية وبصفة خاصة مصر, فضلا عن ان التأثير المحتمل لهياكل ملكية الشركات المختلفة على السلوك المطاطي لتكاليف البضاعة المباعة لم يتم دراسته ايضا من قبل في البيئة المصرية علاوة على انه نادرا ما تم اختبار اثره في الدراسات السابقة بوجه عام. ,This study examines the cost stickiness phenomenon and the potential impact of corporate governance (CG) and ownership structure on cost stickiness magnitude in Egypt, an emerging country that has been under-researched in this context. The study employs four multiple regression models using ordinary least squares (OLS) to analyze the cost of goods sold (COGS) behavior of 85 Egyptian-listed firms, from 2009 to 2013. The results show that the COGS increased by 1.1 0 percent for a I percent revenue increase but decreased by 0.95 percent for a I percent revenue decrease, providing empirical evidence of COGS stickinessin the Egyptian environment. Furthermore, both smaller board size and board independence as measured by the non-role duality of the board chairman were found to reduce COGS stickiness. However, board independence as measured by the percentage of the board’s non-executives was found to increase COGS stickiness. Meanwhile, lower levels of managerial, institutional, and governmental ownership were found to reduce COGS stickiness in the Egyptian environment. This study contributes to the extant literature by exploring the stickness behavior of COGS in the Egyptian environment. Further, Examining the impact of CG variables on the behaviour of COGS in an developing country, namely Egypt which not studied before. Moreover, the potential impact of different ownership structures on cost stickiness not examined before in the Egyptian environment, besides it has rarely been investigated in the prior studies.
The Efficacy of Chlorantraniliprole as a Seed Treatment for Mythimna separata (Walker) (Lepidoptera: Noctuidae)

The oriental armyworm (OAW), Mythimna separata (Walker) (Lepidoptera: Noctuidae), is an important pest in China and causes serious economic losses in corn. The anthranilic diamide, chlorantraniliprole (CHL), has been widely used as a seed treatment to control corn pests; however, no information is available on the efficacy of this insecticide as a seed treatment for OAW. In this study, the efficacy of seed treatment with CHL alone and CHL combined with the neonicotinoid insecticide clothianidin (CHL + CLO) was evaluated for controlling OAW larvae in the laboratory and field conditions. Pot experiments demonstrated that seed treatment with CHL and CHL + CLO (both 240 g a.i. 100 kg−1 seeds) resulted in >79% mortality of OAW larvae and a damage rate <20% in corn at 14 days after seed emergence (DAE). Similar to results obtained in pots, the residual toxicity of CHL and CHL + CLO to OAW larvae in the field declined with DAE and larval development. The control efficacy of field plots treated with CHL and CHL + CLO was >70% within 14 DAE, which was significantly higher than CLO alone. These results suggest that CHL and CHL + CLO as seed treatments could effectively reduce OAW larval infestation in corn. This study validates the effectiveness of corn seed treatment for OAW as an alternative to conventional foliar applications.
Response of Greenhouse Perennial Sweet Pepper Plants to Spraying with Silicate Levels Under Varying Nitrogen and Potassium Fertilizers Levels

There are many problems in the field of agriculture to improve the sustainability of farmed products. Increasing the production costs are one of these problems. In order to investigate the effects of silicate under varying nitrogen and potassium fertilizer levels on perennial sweet pepper plants cultivated in a greenhouses for two consecutive years of (2018/2019 and 2019/2020) by maintaining a balance between vegetative and fruit growth. The experiments were conducted in four greenhouses; the area of each greenhouse was 240 m 2 . Each experiment included 12 treatments, three potassium silicate concentrations (0.0, 0.5 and 1.0 g l -1 ) under four combined treatments of NK ( 25, 50, 100, 125% ) of the recommended dose. Nitrogen doses were 47.5, 71.25, 95.0 and 118.75 kg N fed-1 added via irrigation water while K doses were 0.5, 0.75, 1.0 and 1.25 g as K 2 O doses, which was added by spraying on the leaves of sweet pepper plants (Marvel F1). The results showed that sweet pepper plants fertilized with NK fertilizers at 125 % with potassium silicate at concentrations of 0.5 and 1.0 g l -1 achieved the highest significant increases in mean values of total leaf area plant - 1 compared to untreated plants in both seasons. In addition, increasing levels of NK fertilizers from 50 to 125% of the recommended dose led to increases in relative fruit yield. Furthermore, the results showed that the addition of 0.5 g l -1 of potassium silicate to sweet pepper plants led to a significant increase in the total yield and average fruit weight.
Modified Iterated Extended Kalman Filter for Mobile Cooperative Tracking System

Tracking a mobile node using wireless sensor network (WSN) under cooperative system among anchor node and mobile node, has been discussed in this work, interested to the indoor positioning applications. Developing an indoor location tracking system based on received signal strength indicator (RSSI) of WSN is considered cost effective and the simplest method. The suitable technique for estimating position out of RSSI measurements is the extended Kalman filter (EKF) which is especially used for non linear data as RSSI. In order to reduce the estimated errors from EKF algorithm, this work adopted forward data processing of the EKF algorithm to improve the accuracy of the filtering output, its called iterated extended Kalman filter (IEKF). However, using IEKF algorithm should know the stopping criterion value that is influenced to the maximum number iterations of this system. The number of iterations performed will be affected to the computation time although it can improve the estimation position. In this paper, we propose modified IEKF for mobile cooperative tracking system within only 4 iterations number. The ilustrated results using RSSI measurements and simulation in MATLAB show that our propose method have capability to reduce error estimation percentage up to 19.3% , with MSE (mean square error) 0.88 m compared with conventional IEKF algorithm with MSE 1.09 m. The time computation perfomance of our propose method achived in 3.55 seconds which is better than adding more iteration process.
How Teacher Educators’ Lived Experiences Affect Teaching for Social Justice1

Abstract This article explores the ways in which lived experiences informed literacy teacher educators' (LTEs) pedagogies and practices of social justice. In particular, three case studies were conducted to examine why the LTEs chose to address social justice, as well as how their life experiences influenced their views and pedagogies in their literacy courses to address social justice, race, and race related issues. Each of the LTEs recalled transformative experiences that shaped their views not only of literacy, but the interconnections between schooling, social justice, and race.
How Startups Succeed – A Look at How Architectural Innovation Provides a Competitive Advantage

The recent rise of high profile startups in the news and the prolific attention given to the entrepreneurial culture during an economic makes understanding how startups work a point of interest for many. The glamorization of shows like “Silicon Valley” and the growth of online personalities and their followers makes it even more exciting. But why do so many startups fail so drastically and a few reach unfathomable heights and why are household companies so interested in them? This paper addresses one of the underlying themes that drives business today, specifically, architectural innovation, or how companies organize. By following the diary of the CEO of a locally successful startup, this paper draws conclusions on how organizational architecture impacts a startup’s ability to acquire knowledge that allows it to be competitive.
Dynamic Sensor Scheduling for Target Tracking in Wireless Sensor Networks With Cost Minimization Objective

Wireless sensor networks (WSNs) are demonstrated to be the increasingly essential systems for various Internet of Things (IoT)-based sensing applications. This article proposes a cost-aware dynamic sensor scheduling (CADSS) framework for WSNs with multiple tasks. At its core, a system cost function is designed to quantify the expenses of the WSNs due to task executions, and a task quality function is modeled to indicate the performance of the corresponding tasks. The proposed CADSS is further formulated as an optimization problem to minimize the system cost while maintaining the desired task qualities. In this way, a comprehensive task utility evaluation methodology for self-organized WSNs is constituted. Furthermore, by modeling the posterior Cramér–Rao lower bound (PCRLB) as the task quality function and a weighted sum of the communication and sensor scheduling cost as the system cost, the CADSS is instantiated into a multitarget tracking (MTT) application. It is shown that the formulated CADSS is a nonconvex optimization problem involving two coupled binary variables that, respectively, correspond to the scheduling of sensor and cluster head. We then propose a parallel convex relation approach to solve it effectively. Numerical results verify the effectiveness of the proposed CADSS by comparing it with state-of-the-art strategies.
On-farm Assessment of Cover Crop Management Effects on Plant Tissue Nutrients and Soil pH in the Western Cape Province

 Abstract — The choice of cover crop (CC) species and their growth termination stage is crucial to optimize their benefits. Field experiments were carried out at two sites (Nietvoorbij and Bien donne) in the Western Cape, from 2017 to 2018. This study examined the: (i) Effect of two termination stages (vegetative and flowering) on the chemical composition (C, N and C:N) of four CCs (oats, rye, pea, vetch) and (ii) Short-term impacts of living CCs and residues on soil pH. The experiment was conducted in a randomized block design with three replicates. Plants were sampled at kill while soil was sampled at kill and one year after. Delaying termination from vegetative till flowering increased the total C and C:N ratios of vetch, pea, oats and rye, respectively, while their tissue N decreased, at both sites. CC presence also decreased soil pH at both sites. Results of this study showed that CC tissue and soil C, N, C:N ratios may be manipulated through appropriate species selection and termination stage. However, longer-term studies are needed to evaluate the long-term effects of CC species on soil pH which have the potential to affect microbial activities and nutrient release
Non-linear boundary condition for non-ideal electrokinetic equations in porous media

ABSTRACT This paper studies the partial differential equation describing the charge distribution of an electrolyte in a porous medium. Realistic non-ideal effects are incorporated through the mean spherical approximation (MSA) model which takes into account finite size ions and screening effects. The main novelty is the consideration of a non-constant surface charge density on the pore walls. Indeed, a chemical equilibrium reaction is considered on the boundary to represent the dissociation of ionizable sites on the solid walls. The surface charge density is thus given as a non-linear function of the electrostatic potential. Even in the ideal case, the resulting system is a new variant of the famous Poisson–Boltzmann equation, which still has a monotone structure under quantitative assumptions on the physical parameters. In the non-ideal case, the MSA model brings in additional non-linearities which break down the monotone structure of the system. We prove existence, and sometimes uniqueness, of the solution. Some numerical experiments are performed in 2d to compare this model with that for a constant surface charge.
Towards a new understanding of optical poling efficiency in multimode fibers

All-optical poling was demonstrated for the first time in 1986 in single mode fibers: such nonlinear optical process enabled the introduction of a second-order susceptibility (χ(2)) in a doped silica fiber. By simply using an intense laser source, alloptical poling, later theoretically described by Stolen and coworkers, permitted the generation of a second harmonic (SH) signal in an otherwise centrosymmetric doped material. More recently, similar experiments have been carried out by exploiting complex beam propagation in multimode fibers. In this work we reveal, for the first time to our knowledge, the 3D spatial distribution of a χ(2) nonlinearity written in a graded-index (GRIN) multimode (MM) fiber. In particular, the presence of a doubly-periodic distribution of χ(2) is unveiled by means of multiphoton microscopy. The shortest period (tens of micrometers) is due to the beating between the fundamental and the SH beams, and it is responsible for their quasi-phase matching (QPM). Whereas the longest period (hundreds of micrometers) is associated with the periodic evolution, or self-imaging, of the power density of the MM beam along the GRIN MM fiber. The complex modal beating, leading to spatial self-cleaning of the fundamental beam, is thus printed inside the fiber core, and revealed by our measurements. We considered two fibers of similar composition and opto-geometric parameters, and we compared the evolution of the optical poling process with time. Despite the rather similar fiber characteristics, we observed a striking difference in the poling efficiency between the two fibers. Such observation led us to point out the importance of considering the complete fiber fabrication process (both the preform elaboration and the drawing steps) on the final structure and microstructure of optical fibers.
Antecedents of environmental value creation: an analysis with ecopreneurs in a developing country

ABSTRACT Ecopreneurs emerged as a specific class of entrepreneurs that demonstrate skills to connect business activities with the natural environment. However, while literature has come a long way in addressing drivers and motivations behind value creation in ‘traditional’ entrepreneurs, a conspicuous gap remains when it comes to the generation of environmental value in the ecopreneurial cohort. In this article we assess these relationships by focusing on the impact of ecopreneurial perspectives on environmental value creation, considering the effects of empathy, moral obligation, ecopreneurial self-efficacy, perceived social support, and environmental engagement of ecopreneurs. The sample consisted of 130 ecopreneurs participating in the Atlantic Forest Connection Project in southeastern Brazil, home to one of the most important ecoregions in the world. Analytical procedures involved Partial Least Squares Structural Equation Modeling (PLS-SEM) and fuzzy-set Qualitative Comparative Analysis (fsQCA). According to the PLS-SEM results, antecedents with a positive effect comprehend ecopreneurial self-efficacy, perceived social support, and environmental engagement. Complementarily, the fsQCA analysis indicates that three different configurations are sufficient for a high level of value creation, where empathy and perceived social support function as pivotal elements across paths. These findings contribute to formulating initiatives that aim at fostering sustainable transitions in entrepreneurial ecosystems. The research also contributes with analytical insights to the Sustainable Development Goals (SDGs).
Production Forecasting of Tight Oil Reservoirs Using Improved Decline Model

Tight oil formation has become interest for many researchers since less than 10% of the OOIP can be obtained from the primary recovery. Other thinking on how to improve the oil recovery is still done. Decline curve analysis is one of the methods commonly used to estimate the ultimate recovery and the production rate profile of tight oil reservoirs. The present work uses the Duong model to overcome the limitations of Arps’ model. This study compares the observed values from simulation results to the estimated values from Duong model over 30 years. In our previous work, we demonstrated that some key parameters such as reservoir permeability, number of fractures per stage, fracture permeability, CO2 injection rate, CO2 injection time, CO2 soaking time, number of CO2 huff-n-puff cycle have a great effect on the improve of oil recovery of tight oil reservoirs while applying CO2 huff-n-huff. This work also focused on the development of some regression equations that can help to get approximatively the oil recovery factor of any formation, the goal here is to generate a suite of diagnostic plots to estimate oil recovery. These equations have revealed that the best fit is the polynomial regression. Results show the overestimation of oil reserve by Duong model when the flow regime changes from linear flow.