Miracle-dz/UniFAR-FTUs huggingface dataset:
Nutrition and mental health: A review of current knowledge about the impact of diet on mental health

Applied psychopharmacotherapy and psychotherapy do not always bring the expected results in the treatment of mental disorders. As a result, other interventions are receiving increasing attention. In recent years, there has been a surge in research on the effects of nutrition on mental status, which may be an important aspect of the prevention of many mental disorders and, at the same time, may lead to a reduction in the proportion of people with mental disorders. This review aims to answer whether and to what extent lifestyle and related nutrition affect mental health and whether there is scientific evidence supporting a link between diet and mental health. A review of the scientific evidence was conducted based on the available literature by typing in phrases related to nutrition and mental health using the methodological tool of the PubMed database. The literature search yielded 3,473 records, from which 356 sources directly related to the topic of the study were selected, and then those with the highest scientific value were selected according to bibliometric impact factors. In the context of current changes, urbanization, globalization, including the food industry, and changes in people’s lifestyles and eating habits, the correlations between these phenomena and their impact on mental state become important. Knowledge of these correlations creates potential opportunities to implement new effective dietary, pharmacological, therapeutic, and above all preventive interventions. The highest therapeutic potential is seen in the rational diet, physical activity, use of psychobiotics, and consumption of antioxidants. Research also shows that there are nutritional interventions that have psychoprotective potential.
Normative data for rotational chair considering motion susceptibility

Objective Rotational Chair Test (RCT) is considered one of the most critical measures for vestibular functionality, which generally includes the sinusoidal harmonic acceleration test (SHAT), velocity step test (VST), and visual suppression (VS). The purpose of this study was to establish normal values for different age groups on the RCT and investigate whether motion susceptibility, such as with a history of motion sickness or migraine, has any effects on test metrics. Methods One hundred and nine subjects aged from 20 to 59 years who were free from neurotological and vestibular disorders were enrolled. According to the history of motion sickness or migraine, participants were divided into four groups: the motion sickness (MS) group (n = 13), the migraine group (n = 8), comorbidity group (n = 11), and the control group (n = 77). The 77 subjects without any history of MS and migraine were then further separated into four age groups: youth group (20–29 years), young and middle-aged group (30–39 years), middle-age group (40–49 years), and middle-age and elderly group (50–59 years). All participants underwent SHAT, VST, and VS, and a comprehensive set of metrics including gain, phase, asymmetry, time constant (TC), and Fixation Index were recorded. Results Regarding the VST and VS, no significant differences were observed either across the four groups (MS, migraine, comorbidity, and control group) or four age categories within the control group. For SHAT, VOR gain at the frequency of 0.01 Hz, VOR phase from 0.08 to 0.64 Hz, and asymmetry at 0.01, 0.16, and 0.64 Hz indicated significant differences among various age groups (P < 0.05 for all comparisons). The VOR phase lead was lower in the migraine and comorbidity group than that in the control group at 0.64 Hz (P = 0.027, P = 0.003, respectively). Conclusions Age slightly affects the result of SHAT, but not for VST and VS. VOR gain is more susceptible to aging at low frequency, while the phase is opposite. Subjects with both migraine and motion sickness show abnormal velocity storage mechanisms. Phase bias should be considered when assessing motion susceptibility with the RCT. SHAT is more sensitive than VST in terms of reflecting motion susceptibility.
Multiple myeloma metabolism – a treasure trove of therapeutic targets?

Multiple myeloma is an incurable cancer of plasma cells that is predominantly located in the bone marrow. Multiple myeloma cells are characterized by distinctive biological features that are intricately linked to their core function, the assembly and secretion of large amounts of antibodies, and their diverse interactions with the bone marrow microenvironment. Here, we provide a concise and introductory discussion of major metabolic hallmarks of plasma cells and myeloma cells, their roles in myeloma development and progression, and how they could be exploited for therapeutic purposes. We review the role of glucose consumption and catabolism, assess the dependency on glutamine to support key metabolic processes, and consider metabolic adaptations in drug-resistant myeloma cells. Finally, we examine the complex metabolic effects of proteasome inhibitors on myeloma cells and the extracellular matrix, and we explore the complex relationship between myeloma cells and bone marrow adipocytes.
Multi-depth evolution characteristics of soil moisture over the Tibetan Plateau in the past 70 years using reanalysis products

Soil moisture (SM) is a crucial component of the hydrological cycle. Both the spatial–temporal distribution and the variation characteristics of SM are effective indicators of regional land surface water resource homogeneity and heterogeneity. With consideration of the crucial role of the Tibetan Plateau (TP) in the hydrological process in Asia, this study investigated the fluctuation of multi-depth soil moisture across the TP during 1950–2020 on a monthly scale against the background of global warming by using ERA5 reanalysis datasets. The correlation and potential causality between soil moisture and associated driving factors were explored. Our research revealed that the soil moisture across the TP shows a slight wetting trend at 0–100 cm depth for the past 70 years against the background of climate warming and increasing precipitation. Additionally, the wetting region (variation trend ≥ 0.005 m3/m3 per decade) had sufficient water supplementation from precipitation and a mild soil temperature increase. By comparison, there is a noteworthy warming tendency and falling precipitation in the sparsely distributed drying region (variation trend ≤ −0.005 m3/m3 per decade). In terms of vertical variation features, the temporal dynamic fluctuation of soil moisture and soil temperature evidently decreases as the depth increases, suggesting high sensitivity of the surface layer soil to atmospheric conditions. Precipitation and snowmelt preliminarily proved to be the dominant drivers causing spatial and temporal variations in soil moisture (occupying over 70% of the TP region), and bidirectional causality (ranging between 15.52% and 50.56%) was found between soil moisture and these two parameters. In summary, this study explored the spatial–temporal fluctuation in the evolutionary characteristics of SM, which is expected to advance our understanding of soil moisture dynamics under the conditions of climate change across the TP.
CAQK, a peptide associating with extracellular matrix components targets sites of demyelinating injuries

The destruction of the myelin sheath that encircles axons leads to impairments of nerve conduction and neuronal dysfunctions. A major demyelinating disorder is multiple sclerosis (MS), a progressively disabling disease in which immune cells attack the myelin. To date, there are no therapies to target selectively myelin lesions, repair the myelin or stop MS progression. Small peptides recognizing epitopes selectively exposed at sites of injury show promise for targeting therapeutics in various pathologies. Here we show the selective homing of the four amino acid peptide, cysteine-alanine-lysine glutamine (CAQK), to sites of demyelinating injuries in three different mouse models. Homing was assessed by administering fluorescein amine (FAM)-labeled peptides into the bloodstream of mice and analyzing sites of demyelination in comparison with healthy brain or spinal cord tissue. FAM-CAQK selectively targeted demyelinating areas in all three models and was absent from healthy tissue. At lesion sites, the peptide was primarily associated with the fibrous extracellular matrix (ECM) deposited in interstitial spaces proximal to reactive astrocytes. Association of FAM-CAQK was detected with tenascin-C although tenascin depositions made up only a minor portion of the examined lesion sites. In mice on a 6-week cuprizone diet, FAM-CAQK peptide crossed the nearly intact blood-brain barrier and homed to demyelinating fiber tracts. These results demonstrate the selective targeting of CAQK to demyelinating injuries under multiple conditions and confirm the previously reported association with the ECM. This work sets the stage for further developing CAQK peptide targeting for diagnostic and therapeutic applications aimed at localized myelin repair.
PKIB involved in the metastasis and survival of osteosarcoma

Osteosarcoma is frequently metastasized at the time of diagnosis in patients. However, the underlying mechanism of osteosarcoma metastasis remains poorly understood. In this study, we evaluated DNA methylation profiles combined with gene expression profiles of 21 patients with metastatic osteosarcoma and 64 patients with non-metastatic osteosarcoma from TARGET database and identified PKIB and AIM2 as hub genes related to the metastasis of osteosarcoma. To verify the effects of PKIB on migration and invasion of osteosarcoma, we performed wound-healing assay and transwell assay. The results showed that PKIB significantly inhibited the migration and invasion of osteosarcoma cells, and the Western blot experiments showed that the protein level of E-cad was upregulated and of VIM was downregulated in 143-B cell recombinant expression PKIB. These results indicate that PKIB inhibit the metastasis of osteosarcoma. CCK-8 assay results showed that PKIB promote the proliferation of osteosarcoma. In addition, the Western blot results showed that the phosphorylation level of Akt was upregulated in 143-B cells overexpressing PKIB, indicating that PKIB promotes the proliferation of osteosarcoma probably through signaling pathway that Akt involved in. These results give us clues that PKIB was a potential target for osteosarcoma therapy. Furthermore, combined clinical profiles analysis showed that the expression of AIM2- and PKIB- related risk scores was significantly related to the overall survival of patients with osteosarcoma. Thus, we constructed a nomogram based on AIM2 and PKIB expression–related risk scores for osteosarcoma prognostic assessment to predict the 1-, 2-, 3-, and 5-year overall survival rate of patients with metastatic osteosarcoma, assisting clinicians in the diagnosis and treatment of metastatic osteosarcoma.
Expression and functional analysis of CsA-IPT5 splice variants during shoot branching in Camellia sinensis

Alternative splicing (AS) is a process by which several functional splice variants are generated from the same precursor mRNA. In our recent study, five CsA-IPT5 splice variants with various numbers of ATTTA motifs in the untranslated regions (UTRs) were cloned. Meanwhile, their transient expression, as well as the expression and functional analysis in the two shoot branching processes were studied. Here, we examined how these splice variants regulate the other three important shoot branching processes, including the spring tea development, the distal branching of new shoots, and the shoot branching induced by 2,3,5-triiodobenzoic acid (TIBA) spraying, and thus unraveling the key CsA-IPT5 transcripts which play the most important roles in the shoot branching of tea plants. The results showed that the increased expression of 5′ UTR AS3, 3′ UTR AS1 and 3′ UTR AS2 could contribute to the increased synthesis of tZ/iP-type cytokinins (CKs), thus promoting the spring tea development. Meanwhile, in the TIBA-induced shoot branching or in the distal branching of the new shoots, CsA-IPT5 transcripts regulated the synthesis of CsA-IPT5 protein and CKs through transcriptional regulation of the ratios of its splice variants. Moreover, 3′ UTR AS1 and 3′ UTR AS2 both play key roles in these two processes. In summary, it is revealed that 3′ UTR AS1 and 3′ UTR AS2 of CsA-IPT5 might act as the predominant splice variants in shoot branching of the tea plant, and they both can serve as gene resources for tea plant breeding.
Genetic analysis of a bronze age individual from Ulug-depe (Turkmenistan)

The Oxus Civilisation (or Bactrio-Margian Archaeological Complex, BMAC) was the main archaeological culture of the Bronze Age in southern Central Asia. Paleogenetic analyses were previously conducted mainly on samples from the eastern part of BMAC. The population associated with BMAC descends from local Chalcolithic populations, with some outliers of steppe or South-Asian descent. Here, we present new genome-wide data for one individual from Ulug-depe (Turkmenistan), one of the main BMAC sites, located at the southwestern edge of the BMAC. We demonstrate that this individual genetically belongs to the BMAC cluster. Using this genome, we confirm that modern Indo-Iranian–speaking populations from Central Asia derive their ancestry from BMAC populations, with additional gene flow from the western and the Altai steppes in higher proportions among the Tajiks than the Yagnobi ethnic group.
Spectral and binaural loudness summation of equally loud narrowband signals in single-sided-deafness and bilateral cochlear implant users

Recent studies on loudness perception of binaural broadband signals in hearing impaired listeners found large individual differences, suggesting the use of such signals in hearing aid fitting. Likewise, clinical cochlear implant (CI) fitting with narrowband/single-electrode signals might cause suboptimal loudness perception in bilateral and bimodal CI listeners. Here spectral and binaural loudness summation in normal hearing (NH) listeners, bilateral CI (biCI) users, and unilateral CI (uCI) users with normal hearing in the unaided ear was investigated to assess the relevance of binaural/bilateral fitting in CI users. To compare the three groups, categorical loudness scaling was performed for an equal categorical loudness noise (ECLN) consisting of the sum of six spectrally separated third-octave noises at equal loudness. The acoustical ECLN procedure was adapted to an equivalent procedure in the electrical domain using direct stimulation. To ensure the same broadband loudness in binaural measurements with simultaneous electrical and acoustical stimulation, a modified binaural ECLN was introduced and cross validated with self-adjusted loudness in a loudness balancing experiment. Results showed a higher (spectral) loudness summation of the six equally loud narrowband signals in the ECLN in CI compared to NH. Binaural loudness summation was found for all three listener groups (NH, uCI, and biCI). No increased binaural loudness summation could be found for the current uCI and biCI listeners compared to the NH group. In uCI loudness balancing between narrowband signals and single electrodes did not automatically result in a balanced loudness perception across ears, emphasizing the importance of binaural/bilateral fitting.
Global water distribution in the mantle transition zone from a seismic isotropic velocity model and mineral physics modeling

Although the discoveries of hydrous ringwoodite inclusions and ice-VII inclusions in natural diamonds suggest a hydrous mantle transition zone (MTZ), water content and distribution in the MTZ remain unclear. Here combining a global P- and S-wave isotropic velocity tomography and mineral physics modeling, we image the water distribution in the MTZ. Our results indicate that the MTZ is a main water reservoir inside the Earth, and the total water content of the MTZ is about 0.64–1 seawater. The upper MTZ (410–520 km) and the lower MTZ (520–660 km) contain 0.3–0.5 wt% and 0.15–0.2 wt% water, respectively, implying water contents of the MTZ decrease with increasing depths. The most hydrous regions are mainly located near subduction zones, where the upper MTZ and the lower MTZ can contain water up to 0.5–1 wt% and 0.2–0.5 wt%, respectively, indicating water is transported into the MTZ by hydrous slabs. In addition, old subducted slabs in the western Pacific subduction zone are more hydrous than young subducted slabs in the eastern Pacific subduction zone. We also propose a water circulation model which integrates our results of the water content and distribution in the MTZ.
Performance of a deep learning tool to detect missed aortic dilatation in a large chest CT cohort

Purpose Thoracic aortic (TA) dilatation (TAD) is a risk factor for acute aortic syndrome and must therefore be reported in every CT report. However, the complex anatomy of the thoracic aorta impedes TAD detection. We investigated the performance of a deep learning (DL) prototype as a secondary reading tool built to measure TA diameters in a large-scale cohort. Material and methods Consecutive contrast-enhanced (CE) and non-CE chest CT exams with “normal” TA diameters according to their radiology reports were included. The DL-prototype (AIRad, Siemens Healthineers, Germany) measured the TA at nine locations according to AHA guidelines. Dilatation was defined as >45 mm at aortic sinus, sinotubular junction (STJ), ascending aorta (AA) and proximal arch and >40 mm from mid arch to abdominal aorta. A cardiovascular radiologist reviewed all cases with TAD according to AIRad. Multivariable logistic regression (MLR) was used to identify factors (demographics and scan parameters) associated with TAD classification by AIRad. Results 18,243 CT scans (45.7% female) were successfully analyzed by AIRad. Mean age was 62.3 ± 15.9 years and 12,092 (66.3%) were CE scans. AIRad confirmed normal diameters in 17,239 exams (94.5%) and reported TAD in 1,004/18,243 exams (5.5%). Review confirmed TAD classification in 452/1,004 exams (45.0%, 2.5% total), 552 cases were false-positive but identification was easily possible using visual outputs by AIRad. MLR revealed that the following factors were significantly associated with correct TAD classification by AIRad: TAD reported at AA [odds ratio (OR): 1.12, p < 0.001] and STJ (OR: 1.09, p = 0.002), TAD found at >1 location (OR: 1.42, p = 0.008), in CE exams (OR: 2.1–3.1, p < 0.05), men (OR: 2.4, p = 0.003) and patients presenting with higher BMI (OR: 1.05, p = 0.01). Overall, 17,691/18,243 (97.0%) exams were correctly classified. Conclusions AIRad correctly assessed the presence or absence of TAD in 17,691 exams (97%), including 452 cases with previously missed TAD independent from contrast protocol. These findings suggest its usefulness as a secondary reading tool by improving report quality and efficiency.
Design of 199 to 238 GHz broadband subharmonic mixer combining two‐stage reduced matching technology with Global Design Method

Terahertz technology is widely used in communications, radar, electronic countermeasures, precision guidance, and biomedical applications. In this paper, a 199 to 238 GHz broadband subharmonic mixer combining two‐stage reduced matching technology with Global Design Method is designed, fabricated, measured, and analysed successfully. Compared with traditional single‐stage reduced matching technology and Subdivision Design Method, the two‐stage reduced matching technology is applied for terahertz mixer's Radio Frequency (RF) waveguide and Local Frequency (LO) waveguide, while the LO/Intermediate Frequency (IF) Low‐Pass Filter of terahertz mixers is not necessary to design separately. The core of Global Design Method is that the whole mixer circuit, including LO/RF waveguide, is divided into basic transmission units, which match and filter circuit simultaneously with more optimization variables. When LO driven power is 3.1 mW, LO frequency is 108, 112 GHz. The measured single‐sideband (SSB) conversion loss ranges from 7.84 to 12.4 dB with RF frequency 199 to 238 GHz. The measured double‐sideband (DSB) noise temperature varies between 580 and 1059 K with LO driven power 2 to 5 mW. The multi‐stage reduced matching technology and Global Design Method is general, effective, accurate, can reduce circuit size, simplify circuit structure, broaden frequency band, and can be applied for terahertz harmonically mixers.
INVESTIGATING STUDENTS' - FUTURE TEACHERS' VIEWS ON THEIR INTERNSHIP: BENEFITS AND CHALLENGES

In several countries worldwide, the internship is part of teacher education programs and aims at the professional and personal development of teachers. In Greece, the Pedagogical Departments of Primary Education (PPT) include in their curriculum the students’ practical education which is an internship supervised and supported by teachers - mentors. Through this process, students gain the opportunity to acquire more knowledge of teaching and improve the needed skills, attitudes and values associated with the efficient performance of their job. This case study seeks to unearth the benefits of the internship program and also intends to explore the potential obstacles encountered by students - future teachers during their internship. The qualitative method of research using the semi-directed interview tool was adopted to study the opinion of students - future teachers about the internship program. The survey involved eleven students - future teachers of the Department of Education and Social Work of the University of Patras, who participated in internships in schools in the region of Patras. The results showed that students - future teachers benefited from the development of integrated teaching skills with the proper guidance and support of mentors, yet they simultaneously indicated some potential inhibitory aspects and challenges which arise through their relationship with mentors. Article visualizations:
Airline Based En Route Sequencing and Spacing Field Test Results Observations and Lessons Learned for Interval Management

Airline Based En Route S equencing and S pacing (ABESS ) is a concept of operations that allows airlines to adjust the cruise speed of airplanes during the en-route phase of flight to meet a predetermined inter-aircraft spacing prior to entry into the terminal domain. This preconditioning process is intended to prepare flights for advanced descent procedures including Optimized Profile Descents (OPDs) and Flight-deck based Interval Management (FIM). This paper describes the ABESS concept and a series of four field-tests with the United Parcel Service (UPS ) Airline Operations Center (AOC) where an ABESS software prototype was fielded and tested between 2006 and 2010 during regular UPS operations. Test operations were completed in 2010. The field tests demonstrated flight trajectory predictions of up to 100 minutes that allowed the detection of up to 90 percent of spacing conflicts. The field tests also helped identify additional work areas to make long distance spacing preparations operationally feasible for airlines. This paper discusses the contributors to, and limits of stability for long-term trajectory pre dictions in the context of the flight tests. These findings are expected to be useful for the Next Generation Air Transportation S ystem (NextGen) and S ingle European S ky ATM Research (S ES AR) projects that require longer-term predictions of flight trajectories and fix crossing times during the en route phase of flight.