Miracle-dz/UniFAR-FTUs huggingface dataset:
IDENTIFICATION OF POTENTIALLY INAPPROPRIATE MEDICATIONS USING EXPLICIT CRITERIA AMONG GERIATRIC PATIENTS IN A NIGERIAN SPECIALIST HOSPITAL

Introduction : Potentially inappropriate medications [PIM] are a common cause of morbidity and mortality among the elderly. Detection and prevention of inappropriate medication should be a major concern of prescribers and pharmacists. Several assessment tools are available for detection of PIMs and each one of them have their own limitations. Literature reports reveal wide variations using different tools which makes comparism rather difficult. It is important that PIMs are avoided by using appropriate setting specific tool(s) so as to reduce risk of drug misadventure. Aim : To determine drug prescription pattern and assess prevalence of PIMs. Method : It is cross sectional retrospective study using medication records of geriatric patients attending a Specialist hospital. A total of 500 medical records were selected by simple random sampling method and relevant data extracted for analysis. Result/Discussion : The result showed PIM prevalence is high compared to previous studies. Assessment of PIM produced overall prevalence of 56.1 % most of which were associated with non-steroidal anti-inflammatory analgesics, Benzodiazepines and antidiabetics. The assessment tools produced varying prevalence rates which suggest that no one tool will be effective in detecting all PIMs. Conclusion : The prevalence of PIMs is high, so there is need to improve detection of inappropriate medications in geriatrics in order to prevent adverse drug events.
Free radical anticancer drugs and oxidative stress: ORAC and CellROX-colorectal cancer cells by quantum chemical determinations

Abbreviations OS oxidative stress, ROS reactive oxygen species, ET electron transfer, TRAIL, TNF-related apoptosis-inducing ligand , TNF-alpha tumor necrosis factor, CRC Colorectal cancer, ΔG desolv,CDS free energy of water desolvation, ΔG lipo,CDS lipophilicity free energy, CDS cavity dispersion solvent structure of the first solvation shell, HOMO highest occupied molecular orbital, LUMO lowest unoccupied molecular orbital , R 2 multiple correlation coefficient, the F test of significance, SEE standards errors for the estimate, standard errors of the variables SE(ΔG desolCDS ), SE(ΔG lipoCDS ), SE(Dipole Moment), SE (Molecular Volume), AAPH 2,2'-Azobis-2-methylpropanimidamide, Trolox (6-hydroxy-2,5,7,8- tetramethylchroman-2-carboxylic acid) Abstract It has been shown that the radical form of a wide range of current antineoplastic drugs is involved in oxidative stress processes in human DLD-1 human colorectal cancer cells as determined by the CellROX assay. The oxidative stress capability of these drugs is dependent on the lipophilicity and electron affinity of the drugs in water. All of the drugs examined are known to be involved in oxidative processes to some degree according to literature sources. The antioxidant properties of the radical drug species in the ORAC or ORAC/Cu assays are also dependent on the lipophilicity and electron affinity properties of the drugs. Linear equations have been derived which can predict the oxidative stress in colorectal cancer cells and the redox behavior in the ORAC assays.
Children’s understanding of ethnic group symbols: Piloting an instrument in the Republic of North Macedonia

Assessing children’s awareness of ethnic identity and group boundaries is important in conflict-affected societies. For example, in the Republic of North Macedonia (RNM), tense interethnic relations remain and can be seen in the largely separate living patterns, particularly in schools. This brief report analyses data from 194 children (57.7% female, 42.3% male; 45.9% Macedonian, 54.1% Albanian) in primary school. A series of one sample t-tests, with Bonferroni correction, demonstrate the viability of a new quantitative tool for measuring children’s awareness of symbols relevant to interethnic relations in RNM. The findings indicate that primary school aged children are able to sort both ingroup and outgroup symbols with the hypothesized ethnic group. Moreover, ethnic awareness is present among the earliest school grades and increases with age. This approach may be used in future research and adapted in other conflict-affected settings to better understand the foundations of children’s interethnic attitudes and behaviors.
Influenza Infection Development of Severe Disease during Neutrophils Ameliorate Lung Injury and the

The clinical response to inﬂuenza infection ranges from mild disease to severe pneumonia and it remains unclear whether the inﬂammatory response to infection is protective or pathogenic. We have deﬁned a novel role for neutrophils in ameliorating lung injury during inﬂuenza infection, thereby limiting development of severe disease. Infection of neutrophil-depleted mice with inﬂuenza virus HKx31 (H3N2) led to rapid weight loss, pneumonia, and death. Neutropenia was associated with enhanced virus replication in the respiratory tract; however, viral titers were declining at the time of death, leading us to investigate other factors contributing to mortality. In addition to thymic atrophy, lymphopenia, and viremic spread, depletion of neutrophils led to exacerbated pulmonary inﬂammation, edema, and respiratory dysfunction. Thus, while it is well established that neutrophils contribute to lung injury in a range of pathological conditions, reduced numbers or impaired neutrophil function can facilitate progression of mild inﬂuenza to severe clinical disease. The Journal of Immunology, 2009, 183: 7441–7450. from and in whether the inﬂammation or
The Trojan Formulaic Theater*

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. The Trojan Formulaic Theater* Françoise Letoublon
High Isolation Compact Four-Port MIMO Antenna Loaded with CSRR for Multiband Applications

Abstract In this paper, a compact 4×4 multiple-input-multiple-output (MIMO) patch antenna has been presented for triple band operation. Out of the 4 antennas, two are tuned to cover DCS (Digital Cellular System) downlink and two are tuned to cover DCS uplink frequency separately along with two common operating frequency centered around 2.45 GHz and 875 MHz. Four complementary split-ring resonators (CSRRs) have been etched in the ground plane exactly below the four patch antennas for attaining compactness from 0. 36λ02 to 0. 13λ02. In addition to this, by optimizing CSRRs outer radius, one lower common band operation of around 875 MHz (0.031λ02) has been obtained. Two, square split-ring resonators (SRRs) are placed between patch antennas to increase isolation by almost 7 dB around DCS band. The proposed MIMO antenna has been fabricated on an FR4 substrate (60×60×0.8) mm3 with dielectric constant, εr=4.3 having an antenna area of 0. 13λ02. The Proposed MIMO antenna has two common operating bands, 850–900 MHz, 2410–2466 MHz and one individual band from 1725–1770 MHz for one group of two antennas of dimensions 17×22 mm2 and another individual band from 1800–1845 MHz for another group of two antennas of dimensions 17×23 mm2, where reflection coefficient is less than −10 dB with a minimum isolation of 17 dB. Diversity performance of the proposed MIMO antenna has been verified experimentally on all three bands. However, there is a slight deviation in the DCS operating band due to two different groups of antennas.
Thermal Poststorage Treatment for Maintaining Fruit Quality and Extending Storage Life of Pomegranate Wonderful Cultivars

Cold storage is a widely used method for prolonging pomegranate fruit shelf life. However, low storage temperature may result in fruit decayed and chilling injury. So, this experiment was conducted to investigate the effect of different storage temperature (5, 10, and 20 °C with 85-90% RH) for maintaining quality criteria and storage period prolongation of pomegranate fruits cv. wonderful during 2018 and 2019 seasons. Fruit quality characteristics i.e., fruit weight, volume, length, and diameter, total aril weight, total juice weight and color parameters, of skin, aril and juice were investigated. Soluble solids content (TSS), total acidity (TA), ascorbic acid content (vitamin C), and total anthocyanin content were measured periodically for a storage period of 30 days for 5, 3 and 2 months respectively. Results indicated that pomegranate fruits stored at 5°C showed lower weight loss percent and higher firmness than that occurred in fruit stored at 10 and 20°C with more expand storage period. Pomegranates stored at 5°C recorded the highest fruit weight, fruit volume, aril weight and juice weight with the lowest fruit specific gravity after four months . While, the highest fruit length and diameter were noted at 10°C storage after the third month . The highest anthocyanin content was recorded for pomegranate fruits after five storage months at 5 ° C. Lightness (L) and Chroma (C*) colour parameters in skin and aril of wonderful pomegranate fruits had higher gradual increment compared with its values at harvest. Meanwhile, hue angle (H 0 ) color parameter clarified remarkable reduction trend throughout different storage temperatures such as 5, 10 and 20 °C with expanding storage periods. On the other side, fruit juice colour (Lightness (L*) and Chroma (C*)) cleared a significant decrease with a noticeable increment for hue angle (h o ) respectively compared with initial value at harvest. From these results it can be concluded that cold storage at 5°C was better than storage at 10 and 20 °C for expanding the market duration of pomegranate fruits.
U NIVERSITY OF Z ARAGOZA N ANOSTRUCTURED N ANOTECHNOLOGY Carbonaceous Platforms for the Fabrication of Green Molecular Electronic Devices

The research on the development of electronic devices is growing as fast as ever. As new challenges arise with the continuous miniaturisation of electronic components, nanostructured and carbon-based materials have been become very promising for future developments and products. In this project, an all-carbon molecular electronic device, which is completely free of metals, is reported. A Langmuir ﬁlm of graphene oxide (GO) was fabricated and characterised by using a Brewster angle microscope (BAM). Then, transferences of a GO Langmuir-Blodgett (LB) ﬁlm onto mica substrate for different transference conditions were carried out. Morphology of the samples were characterised by using an atomic force microscope (AFM). Once the optimum transference conditions of GO LB ﬁlm were determined, electrografting processes of Oligo(Phenylene Ethynylene) (OPE) derivatives onto highly oriented pyrolytic graphite (HOPG) substrate were carried out. After monolayers of OPE derivatives onto HOPG were conﬁrmed by using various characterisation techniques such as Raman spectroscopy, AFM and cyclic voltammetry (CV), transferences of GO LB ﬁlm onto modiﬁed HOPG substrates were carried out. Future work to achieve all-carbon molecular electronic devices is also explained.
Effect of Low Light Stress on Photosynthetic Pigments and Antioxidative Enzymes in Field Grown Indian Mustard ( Brassica juncea L.) Genotypes

: Oilseed Brassicas have prominent place after soybean and groundnut. More than 90% of the area under oilseed Brassicas is occupied by the Indian mustard ( Brassica juncea ) because of its relative tolerance to biotic and abiotic stresses as compared to other oilseed Brassica species. Light plays key a role in net primary productivity and is necessary for plant growth , morphogenesis and several physiological processes. The present investigation aimed to assess the effect of low light stress on photosynthetic traits and antioxidative enzymes in Brassica juncea genotypes. Shading was imposed with nets from mid-December to mid-January which cut 25%-30% of natural sunlight. Shading period coincided with the onset of flowering. The results showed that chlorophyll b and antioxidant activities of superoxide dismutase (SOD), guaiacol-peroxidase (G-POD) and catalase (CAT) increased under low light stress at two stages of investigations (10 and 30 days after removal of nets). With shading treatment, soil plant analysis development (SPAD) chlorophyll meter values, chlorophyll a , total chlorophyll, chlorophyll a / b ratio, carotenoid and protein content decreased significantly while malondialdehyde content increased due to damages of plant cells. This study provides valuable information for further deciphering genetic mechanism and improving agronomic traits in Indian mustard cultivated under optimal light requirements.
Reframing construction within the built environment sector

Official statistics on the output of the construction industry capture on-site activities of contractors and sub-contractors; however, the role of the industry linking suppliers of materials, machinery, products, services and other inputs is also widely recognised. These two views have been called broad and narrow, with the narrow industry defined as on-site work and the broad industry as the supply chain of materials, products and assemblies, and professional services. An argument is made for using the term “built environment sector” (BES) for the broad industry definition of construction. The paper aims to discuss these issues. ,Construction industry statistics capture the on-site activities of contractors and sub-contractors. This paper reviews research that adds to construction output the contributions of suppliers of materials, machinery and equipment, products and components, professional services and other inputs required to deliver the buildings and structures that make up the built environment. ,The same term, “construction”, has been used in a number of ways in different definitional studies of the narrow and broad industry. The term that best encompasses the large number and range of participants in the creation and maintenance of the built environment, from suppliers to end users, is the BES. ,Construction economics makes an important contribution to researching the macroeconomic role of the BES. There is also a special role for construction economics in researching both the boundaries of the BES and the data available on the industries that contribute to the BES. ,Measuring the BES would improve the understanding of its macroeconomic role and significance. ,Measuring the BES would contribute to city policies and urban planning. ,The paper proposes a new approach to defining and measuring the industries that contribute to the production, maintenance and management of the built environment. It introduces a new name for the combination of those industries.
Title: T2 heterogeneity as an in vivo marker of microstructural integrity in medial temporal lobe subfields in ageing and mild cognitive impairment

A better understanding of early brain changes that precede loss of independence in diseases like Alzheimer’s disease (AD) is critical for development of disease-modifying therapies. Quantitative MRI, such as T2 relaxometry, can identify microstructural changes relevant to early stages of pathology. Recent evidence suggests heterogeneity of T2 may be a more informative measure of early pathology than absolute T2. Here we test whether T2 markers of brain integrity precede the volume changes we know are present in established AD and whether such changes are most marked in medial temporal lobe (MTL) subfields known to be most affected early in AD. We show that T2 heterogeneity was greater in people with mild cognitive impairment (MCI; n=49) compared to healthy older controls (n=99) in all MTL subfields, but this increase was greatest in MTL cortices, and smallest in dentate gyrus. This reflects the spatio-temporal progression of neurodegeneration in AD. T2 heterogeneity in the entorhinal cortex also predicted cognitive decline over a year in people with MCI, where measures of volume or T2 in any other subfield or whole hippocampus could not. Increases in T2 heterogeneity in MTL cortices may reflect localised pathological change and may present as one of the earliest detectible brain changes prior to atrophy. Finally, we describe a mechanism by which memory, as measured by accuracy and reaction time on a paired associate learning task, deteriorates with age. Age-related memory deficits were explained in part by lower subfield volumes, which in turn were directly associated with greater T2 heterogeneity. We propose that tissue with high T2 heterogeneity represents extant tissue at risk of permanent damage but with the potential for therapeutic rescue. This has implications for early detection of neurodegenerative disease. support previous evidence that absolute T2 is not a sensitive marker of early pathology, rather, heterogeneity of T2 is much more sensitive to early pathological change and differs between subfields in a manner which reflects the order of NFT deposition in prodromal AD. We provide evidence that although T2 heterogeneity increases with age in all subfields, the degree to which this occurs is subfield-dependent and is strongest in MTL cortical regions (EC and BA35). In contrast, we do not see systematic evidence of a relationship between age and absolute T2. Using path analysis we describe a pathway through which cognition is significantly affected by age through direct effects on T2 heterogeneity in cognitively healthy older people, which in turn has direct effects on volume which lead to changes in cognition, supporting the idea that T2 changes precede and lead to volumetric changes. Finally, we show that the single best predictor of cognitive decline in people with MCI is greater T2 heterogeneity within entorhinal cortex, outperforming both T2 midpoint and, critically, volume of any subfield.
Non-Destructive, Self-Contained Extraction Method of Parasitic Resistance in HEMT Devices

This contribution addresses the classical problem of determining the extrinsic resistances ( R G , R S and R D ) of ﬁeld-eﬀect transistors (FETs), and in particular of high-electron mobility transistors (HEMTs). The presented approach relies on small-signal measurements of open-channel transistors, as often proposed both for traditional metal-semiconductor FETs (MESFETs) and HEMTs. Unlike what is common practice with HEMTs, the method proposed here does not oversimplify the model of the active channel. On the contrary, the Authors retrieve from the literature a possible analytical model for the open-channel HEMT and use it to determine the triplet of extrinsic resistances without the need of stressing the gate junction with too high currents. Another result of the approach, valid both for MESFETs and HEMTs, is a deterministic way to remove the contribution of the gate junction from the small-signal parameters of the measured devices. All extractions process data which are available on suitable ranges in frequency or in bias voltage, without taking to the limit the sweep parameters or seeking speciﬁc resonances. Also, optimizations are only allowed to reﬁne the nominal values, not as the main technique of extraction. These goals are achieved by setting up diﬀerent subproblems in the form of over-determined linear systems and then solving by pseudo-inversion. The validity of the approach is demonstrated on measurements of devices from advanced HEMT technologies realized by OMMIC, both GaAs-based (40 nm gate length) and GaN-based (100 nm and 60 nm).
Testing of an automatically generated compiler Review of retargetable testing system

— for testing automatically generated C compiler for embedded systems on simulator, it is necessary to have corresponding support in the simulator itself. Testing programs written in C very often use I/O operations. This functionality can not be achieved without support of the C library. Hence the simulator must provide the interface for calling the functions of the operation system it runs on. In this paper, we provide a method that enables running of programs, which use functions from the standard C library. After the implementation of this approach we are able to use the function provided by the C library with limitations given by the hardware. Moreover we add the overview of the testing system, which is used in our project. The system allows testing hardware and also software part of the project.
Human Arachidonic Acid Reacylation Reactions in Acyltransferase 3 in Receptor-Regulated Signaling Role for Lysophosphatidylcholine

Cellular availability of free arachidonic acid (AA) is an important step in the production of pro- and anti-inﬂammatory eicosanoids. Control of free AA levels in cells is carried out by the action of phospholipase A 2 s and lysophospholipid acyltransferases, which are responsible for the reactions of deacylation and incorporation of AA from and into the sn-2 position of phospholipids, respectively. In this work, we have examined the pathways for AA incorporation into phospholipids in human monocytes stimulated by zymosan. Our data show that stimulated cells exhibit an enhanced incorporation of AA into phospholipids that is not secondary to an increased availability of lysophospholipid acceptors due to phospholipase A 2 activation but rather reﬂects the receptor-regulated nature of the AA reacylation pathway. In vitro activity measurements indicate that the receptor-sensitive step of the AA reacylation pathway is the acyltransferase using lysophosphatidylcholine (lysoPC) as acceptor, and inhibition of the enzyme lysoPC acyltransferase 3 by speciﬁc small interfering RNA results in inhibition of the stimulated incorporation of AA into phospholipids. Collectively, these results deﬁne lysoPC acyltransferase 3 as a novel-signal–regulated enzyme that is centrally implicated in limiting free AA levels in activated cells. The Journal of Immunology , 2010, 184: 000–000. In the current work, we have studied the AA incorporation pathways in human monocytes stimulated with zymosan. Our results indicate that stimulated cells exhibit an enhanced incorporation of AA into PLs that is not secondary to an increased lysophospholipid availability due to cPLA 2 a activation but rather reﬂects a true receptor-regulated nature of the AA reacylation pathway. Our studies indicate that the receptor-sensitive step of the AA reacylation pathway is at the lysoPC:arachidonoyl-CoA acyltransferase (LPCAT) level and deﬁnes the enzyme LPCAT3 as a signal-regulated enzyme.
University Teachers’ Attitudes Towards Distance Learning During COVID-19 Pandemic: Hurdles, Challenges, and Take-away Lessons

The current paper discussed the challenges encountered by university teachers during online education in Morocco. It also investigated teachers ’ attitudes towards their distance teaching experience. 156 Chouaib Doukkali University teachers, (male=85 and female=71) were administered an online questionnaire via their professional email addresses. The participants, belonging to five faculties, were kindly invited to fill out the question within two weeks. For triangulation purposes, 20 (male=12 and females=8) informants were interviewed about their experience with distance education. Quantitative data were analyzed through descriptive statistics to extract demographic characteristics of the participants and provide measurements of mean values, standard deviations, and frequencies of the variables. Qualitative data were thematically analyzed. Findings showed that although the vast majority of the respondents used online teaching, many faced both technical and logistical barriers, which were reported to impede the good delivery of lessons. Also, the majority of the participants showed a negative attitude towards the COVID-19 online teaching experience. The study discusses some implications for online teaching practice in tertiary education in Morocco.