Miracle-dz/UniFAR-FTUs huggingface dataset:
LxTube - Processing of massive video archives in order to index and search information

—The rapid growth of video databases available online demands more efﬁcient and robust search engines and indexing systems. The key challenges when developing such systems are: 1) Identiﬁcation of the best features to represent the video; 2) Identiﬁcation of the best way to index these features. For the former it is crucial that we come to a compromise between a perfect description of the video and the memory allocation and the time costs involved in the extraction process of the features. The algorithm adopted for the second challenge deﬁnes how the data will be organized in the database and, consequently, the speed of retrieval and the quality of the results. In this work I will present an approach to this type of problem, where four different types of features are used (Color, Texture, Semantic Information and Motion) and a hierarchical k-means clustering algorithm is applied to index the database information. This indexing step helps to identify the database’s most similar frames to each of the frames of the query video in order to produce a graph used in the similarity evaluation process between the video of query and the videos of the database. The graph construction process can be adapted to produce different outputs according to the intentions of the user, which illustrates one of the great advantages of this algorithm, its enormous versatility. We also tested the scalability of the algorithm in a database with 43000 videos extracted from the Youtube-8M dataset.
Parallel and Distributed Stream Processing: Systems Classification and Specific Issues

Deploying an infrastructure to execute queries on distributed data streams sources requires to identify a scalable and robust solution able to provide results which can be qualified. Last decade, different Data Stream Management Systems have been designed by exploiting new paradigm and technologies to improve performances of solutions facing specific features of data streams and their growing number. However, some tradeoffs are often achieved between performance of the processing, resources consumption and quality of results. This survey 5 suggests an overview of existing solutions among distributed and parallel systems classified according to criteria able to allow readers to efficiently identify relevant existing Distributed Stream Management Systems according to their needs ans resources.
Automatic Diagnosis of Security Events in Complex Infrastructures using Logs

—The management of complex network infrastructures continues to be a difﬁcult endeavor today. These infrastructures can contain a huge number of devices that may misbehave in unpredictable ways. Many of these devices keep logs that contain valuable information about the infrastructures’ security, reliability, and performance. However, extracting information from that data is far from trivial. In this paper we present a novel approach to assess the security of such an infrastructure using its logs, inspired on data from a real telecommunications network. We use machine learning and data mining techniques to analyze the data and semi-automatically discover misbehaving hosts, without having to instruct the system about how hosts misbehave
Escitalopram 10mg/day is e¡ective and well tolerated in a placebo-controlled study in depression in primary care

Escitalopram, a selective serotonin reuptake inhibitor (SSRI), was compared to placebo in a study of patients with major depressive disorder (DSM-IV) who had baseline Montgomery–Åsberg Depression Rating Scale (MADRS) total scores Z22 and r40. After a 1-week, single-blind placebo period, patients were randomized to receive escitalopram 10 mg/day (n=191) or placebo (n=189) in an 8-week, double-blind period. The primary efficacy analysis of adjusted mean change in MADRS total score from baseline showed a statistically significantly larger effect for escitalopram than for placebo with a treatment difference at week 8 (last observation carried forward, LOCF) of 2.7 points (SE 0.85; P=0.002). In further by-week efficacy analyses, the effect of escitalopram was consistently larger than that of placebo (Po0.05) beginning at week 1 (Clinical Global Impression–Improvement score), week 2 (MADRS score) or week 3 (Clinical Global Impression–Severity score). Escitalopram was very well tolerated with a low overall withdrawal rate similar to that for placebo. Nausea was the only adverse event reported significantly more in escitalopram-treated patients than in placebo-treated patients, although it was infrequent and transient. Escitalopram 10mg/day had a statistically significantly better antidepressant effect than placebo as early as week 1, and was safe and very well tolerated. Int Clin Psychopharmacol 17:95–102 r 2002 Lippincott Williams & Wilkins
Therapeutic e¡ects of milnacipran, a serotonin and noradrenaline reuptake inhibitor, on post-stroke depression

Depression is common after stroke. While several reports have been published on the use of antidepressants such as selective serotonin reuptake inhibitors and tricyclics for the treatment of post-stroke depression (PSD), no previous study has examined the use of a selective serotonin and noradrenaline reuptake inhibitor (SNRI) for this condition. The present study investigated the efficacy and safety of milnacipran, a SNRI, for the treatment of PSD. A 6-week open study was conducted in 12 patients (two males and 10 females) aged 53–88 years. All patients were diagnosed with major or minor depressive disorder according to DSM-IV, where onset was subsequent to a cerebral infarction or haemorrhage (stroke). Severity of depression was assessed using the 21-item Hamilton rating scale for depression (HAM-D). The maximum total daily dose of milnacipran was in the range of 30–75 mg b.i. d. Three patients experienced side-effects, but none of the side-effects were serious. Two patients dropped out of the study. At the end of the study, 58.3% (7/12) of the total patient population and 70% (7/10) of the patients completing the study were in remission (a final HAM-D score of less than 7 and no longer meeting criteria for major or minor depression). These results suggest that milnacipran may be an effective treatment for PSD. Int Clin Psychopharmacol 17:121–125 r 2002 Lippincott Williams & Wilkins
PDFlib PLOP: PDF Linearization, Optimization, Protection Page inserted by evaluation version

Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neoplasms etiologically linked to viral factors. Chronic infections with the hepatitis B virus (HBV) and the hepatitis C virus (HCV) have been implicated in about 80% of cases worldwide, and other known environmental risk factors, including alcohol abuse and dietary intake of aflatoxin B1, might synergize with viral infections. Recent insight into the molecular mechanisms leading to HCC development has been provided by the identification of major genetic abnormalities revealed by genomewide allelotype studies and molecular cytogenetic analysis. Moreover, several oncogenic pathways have been implicated in malignant transformation of liver cells. Inactivation of the p53 tumor suppressor gene by mutations and allelic deletions in about 30% of HCC cases has been associated predominantly with exposure to aflatoxin B1 and HBV infection. By contrast, a mutation in the -catenin gene in around 22% of HCCs is more rare in HBV-associated tumors. Activation of cyclin D1 and disruption of the Rb pathway are also commonly involved in liver tumorigenesis. New major challenges include the identification of candidate genes located in frequently altered chromosomal regions and that of oncogenic pathways driven by different risk factors. This search might shed some light on the tumorigenic role of HBV and HCV. It might also permit accurate evaluation of major targets for prognostic and therapeutic intervention.
ID-D-14-00142 96..100

I mplant drilling procedures could cause a temperature rise in the surrounding hard tissue. Many in vitro evaluations have demonstrated heat generation and subsequent bone overheating when incorrect surgical protocols were performed. Different temperature values were reported in different published articles because a large number of factors are involved during drilling heat generation. Pressure applied, drill speed, drill material, drilling depth, drill sharpness, drill diameter, number of drill uses, and irrigation method could significantly influence the temperature rise. Albrektsson et al reported that a temperature rise until dangerous level could lead to cell necrosis and degeneration of some proteins. The temperature threshold level for thermal bone tissue injury was first set at 56°C and then Eriksson and Albrektsson’s study demonstrated that heating the bone up to 47°C or 50°C for 1 minute could be sufficient to impair the bone formation in rabbit cortical bone. Their study was performed using a dividable titanium structure with a 1-mm-wide transverse canal in which the authors could evaluate the thorough bone growth. The authors were only able to evaluate the bone growth inside the canal and did not focus on the implant osseointegration because they did not place real titanium dental implants. The titanium structure was inserted in rabbit tibia that is mainly composed of cortical bone, and it is not clarified if the cancellous bone could have the same clinical behavior. A recent study demonstrated histologically in cortical bone, with an in vivo model, that bone overheating due to insufficient bur irrigation, before implant insertion, could have some negative effects on titanium dental implant osseointegration but they did not measure the bone temperature achieved. In a subsequent study, Trisi et al reported that cortical bone heating before implant insertion (sheep mandible) up to 60°C for 1 minute did not impair the osseointegration, but it was enough to create periimplant infrabony pockets statistically deeper than the control group. The *Scientific Director, Biomaterial Clinical Research Association, Private Practice, Pescara, Italy. †Biomaterial Clinical Research Association, Private Practice, Pescara, Italy. ‡“G. Caporale” Institute, Teramo, Italy.
The Molecular Anatomy of Myelodysplastic Syndromes: An Update

Aims: Myelodysplastic syndromes (MDS) are a group of clonal haematopoietic disorders arising from blood stem cells. Their main characteristics are a wide range of cytopenias and ineffective haematopoiesis. The purpose of this review was to summarise the current knowledge on the molecular biology of MDS the impact of gene mutations on the outcome of the disease. Materials and Methods: A thorough search of PubMed was conducted and a review of the current literature. Results: The introduction of novel techniques in molecular biology (real-time PCR, next generation sequencing) has led to the identification of a series of mutations associated with prognosis of MDS patients and response to therapy and the development of novel prognostic models classifying MDS patients into risk groups. Those mutations include chromosomal aberrations and point mutations involving genes associated with mRNA splicing, methylation, signal transduction, regulation of transcription and cell cycle and other cellular pathways. Conclusion: Further studies will be needed in order to define the precise role of those mutations in prognosis and therapy of MDS. Review Article Kotsiri et al.; JAMMR, 28(4): 1-23, 2018; Article no.JAMMR. 45213 2
Prospects of nanotechnology in Indian farming

Nanotechnology is an emerging field of science widely exploited in electronics, energy, environment and health sectors. Indeed, nanotechnology applications in agriculture is rarely studied in India and abroad. But many research organizations and universities have begun to invest in order to gain solutions to unresolved field poblems. The Tamil Nadu Agricultural University, Coimbatore, is one of the early birds in such endeavours to initiate research in the fascinating field of science. The reported literatures across the globe suggest potentials of nanotechnology applications in biological sciences including agriculture. In this review, applications of nanotechnology in agricultural sciences such as nanoagricultural inputs, nano-food systems, nano-biotechnology and nano-remediation have been summarized.
Quality Program: what influences the opinion of nursing team

ABSTRACT Objective To analyze the major impact variables in the opinion of nursing staff about the Quality Program of a teaching hospital. Methods An exploratory-descriptive study was performed with 72 nursing staff. Data were collected through self-administered questionnaire containing 24 statements about the Quality Program; and the degree of agreement of the participants was expressed in a Likert scale. The collected data were analyzed by factor analysis and Pearson’s correlation coefficient. Results The analysis grouped the statements in six factors. The Pearson’s correlation coefficient defined a scale of influence of the variables within each factor, whose variable with the greatest impact in each factor is the priority issue for improving worker opinion about the Quality Program. The priority variables were to believe the Quality Program contributes to the hospital; to understand the program orientations; interest in hospital quality direction; and do not feel exhausted due to the program. Conclusion These variables must be focused during the implementation and execution of Quality Program, as they have greater impact on improving opinion regarding the Quality Program and thus helping to increase compliance of the nursing staff to the program.
Diversité bactérienne associée aux organes excréteurs des Nautiloides : caractérisation du système symbiotique, implications évolutives et physiologiques

Les appendices pericardiques des Nautiloides (origine cambrienne ~500 MA) cumulent les trois processus lies a la fonction d’excretion (filtration, reabsorption, secretion). Les bacteries symbiotiques abritees dans ces organes chez deux especes de Nautiloides : Nautilus macromphalus (Nouvelle-Caledonie) et Nautilus pompilius (Philippines et Vanuatu) ont ete caracterisees par differentes approches (sequencage de l’ARNr 16S, CARD-FISH, TEM). L’analyse phylogenetique a permis de proposer l’hypothese nouvelle d’une «double symbiose» specifique impliquant deux groupes bacteriens (beta proteobacteries et spirochetes) presents chez tous les specimens dans les trois zones geographiques etudiees. L’hybridation de sondes specifiques in situ a revele une distribution des symbiotes en etroite liaison avec l’ultrastructure fonctionnelle de l’organe hote. De plus, l’incubation isotopique du complexe symbiotique supporte l’hypothese d’une contribution des symbiotes dans le metabolisme azote de l’hote.
Exploring the Effects of Nurses’ Family-Work Conflict on Patient Care Quality: A Qualitative Study

Background: Nurses need to perform different roles and fulfill different responsibilities. Thus, they experience great levels of strain, which result in conflicts between their family and work. Such conflicts may negatively affect their professional performance. Objectives: The aim of this study was to explore the effects of nurses’ family-work conflict on patient care quality. Methods: This qualitative study was conducted using the content analysis approach. Fifteen nurses (ten females and five males) were purposively selected. In-depth unstructured interviews were held for data collection. The data were analyzed through Graneheim and Lundman’s content analysis approach. Results: The effects of nurses’ work-family conflict on patient care quality fell in three main themes, namely reduced mental ability for care provision, low care-providing morale, and damages to professional communications. Each of these themes had two subthemes, which were respectively poor concentration on care provision, impreciseness in care provision, poor job motivation, job dissatisfaction, challenges in establishing relationships with patients, and problems in establishing relationships with other
Volume computed tomography dose index (CTDIvol) and size-specific dose estimate (SSDE) for tube current modulation (TCM) in CT scanning

Background: In the tube current modulation (TCM) technique, tube current is changed dynamically during the scanning process. To quantify the effect of a dynamic tube current, a distinct calculator is needed to estimate the CT output radiation dose in terms of volume CT dose index (CTDIvol) and individual patient dose in terms of size-specific dose estimate (SSDE). This study developed a specific calculator for CT scanning using the TCM technique. Materials and Methods: The tube current was extracted from the DICOM header for every slice, and averaged over the scan length. The water equivalent diameter (Dw) and SSDE values were calculated for each tube rotation. The software was retrospectively applied to 57 patients who had undergone abdominal and thoracic CT examinations using a multi -detector CT, the Somatom Emotion 6. Results: The differences between the calculated CTDIvol and the CTDIvol reported by the CT scanner were 4.4 ± 1.2% and 6.0 ± 2.0% for abdominal and thoracic examinations, respectively. The average tube current was found to be linearly correlated with Dw with R 2 values of 0.707 and 0.696 for abdominal and thoracic examinations, respectively. The average tube current was also linearly and strongly correlated with the SSDE with R values of 0.941 and 0.887 for abdominal and thoracic examinations, respectively. Conclusion: Calculator for estimating CTDIvol and SSDE specifically for TCM in CT scanning has been successfully developed. The difference between calculated CTDIvol values using this calculator and reported CTDIvol values were less than 10%.
PRIMARY PSYCHIATRIC PREVENTION : PROBLEMS AND PROSEPECTS1

X he interest in preventive psychiatry was given a great fillip with the advent of the Community Psychiatry movement in the U.S.A. in the early sixties. Caplan (1964) saw primary prevention as an essentially public health concept. It aims at reducing the incidence (occurrence of fresh or new cases) of psychiatric disorders of all types in a community and at promoting mental health among its members. He admitted that few of the principles enunciated in the pages of his book on Prentive Psychiatry (Caplan, 1964) were based on solid research findings or even on consensus among experts. He conceded that no organised programme for prevention of specific mental disorders existed and the necessarry knowledge for that purpose was lacking. He did hope however, that epidemiological and other types of aetiological research as well as evaluative study of the effects of differing methods on a variety of disorders will one day make this posible. Today 37th year later, Caplan's hope still remains largely unrealised. In fact, for a long time after Caplan's formulation of the principLes and practice of Primary Prevention in Psychiatry, there was considerable lack of activity in the field till 1978. The president's Commission of Mental Health in U.S.A. (1978) stated in its report to the president: "At present our effort to prevent mental illness or to promote mental health are unstructured, unfocused and un-coordinated. They command few dollars, limited personnel, and little interest at levels, where resources are sufficient to achieve results. ". Though considerable progress in activity was evidenced in subsequent years, in the preventive field in U.S.A. , it was felt 8 years later that "prevention has a long way to go to be accorded an equitable share, when the various mental health budgets are apportioned, and the concept of prevention is neither fully understood nor heartily endorsed by all decision makers" (Goldstone, 1986).
Analysis of the Treatment Efficacy of Percutaneous Catheter Drainage Under CT Guidance for Severe Acute Necrotizing Pancreatitis

Background: Percutaneous catheter drainage (PCD) therapy is an important treatment for severe acute pancreatitis. Objectives: The purpose of this retrospective study was to analyze the relevant risk factors of computed tomography (CT) guided PCD during the treatment of infected pancreatic necrosis (IPN) in severe acute pancreatitis. Patients and Methods: This is a retrospective study. From January 2013 to November 2016, 162 patients suffering from severe acute pancreatitis with IPN were assessed using CT-guided PCD. Abdominal CT scan was performed for the patients. The interventional therapist chose the location and puncture according to the image. Depending on the efficacy and process of the treatment, these patients were divided into a PCD success treatment group and a PCD combined with surgery group. Factors affecting the success of PCD treatment were analyzed by logistic regression analysis. Results: Among the 162 cases, 71 cases (43.82%) were in the PCD success group and 91 cases (56.17%) were in the PCD combined with surgery group. Through the course of treatment, CT values of piercing zone, acute physiology and chronic health evaluation II (APACHEII) scores and modified CT severity index (MCTSI) scores showed statistically significant correlation with the therapeutic effect of PCD under CT guidance. A further multivariate analysis found that the CT value of puncture area is the best predictor for efficacy and when the CT value got higher the PCD efficacy would become lower. We performed further analysis of the factors associated with the average CT value in the puncture area which was higher than 20 Hounsfield unit (HU), and found that the length of time from patient admission to drainage, APACHEII scores, MCTSI scores and C reactive protein (CRP) levels were risk factors for PCD treatment efficacy. Conclusion: CT values of piercing zone is the major risk factor affecting the curative effect of CT guidance PCD. For patients with higher CT values in the puncture area, the longer time from patient admission to drainage, the higher APACHEII scores and MCTSI scores. Higher levels of C reactive protein seem to lower the curative effect.
Burden of vasomotor symptoms in France, Germany, Italy, Spain, and the United Kingdom

Background Several studies have documented a significant association between vasomotor symptoms (VMS) and a decrement in health outcomes among postmenopausal women, but these studies have mostly focused on the US. The aim of the current study was to broaden this investigation by examining the burden of VMS symptoms in the European Union with respect to both humanistic and economic outcomes. Methods All women aged 40–75 years who completed the 2010 5EU (France, Germany, Italy, Spain, and the UK) National Health and Wellness Survey were identified as potential respondents and invited to participate in an additional cross-sectional, Internet-based survey. Only postmenopausal women from 5EU were included in the current analyses (n = 3801). VMS was assessed using the Menopausal Rating Scale, and was used in multiple regression models as the primary predictor of health status (EQ-5D-3L), work productivity loss, and the number of physician visits due to menopause. Results Over half (50.3%) of postmenopausal women experienced either mild (24.6%), moderate (17.6%), or severe (8.1%) VMS. Controlling for confounding variables, mild (b = −0.03, P < 0.05), moderate (b = −0.07, P < 0.05), and severe VMS (b = −0.17, P < 0.05) were each associated with worse health utilities relative to women without VMS. Similarly, increased resource use (b = 1.04–2.39, all P < 0.05), overall work impairment (b = 8.71–19.69, all P < 0.05), and activity impairment (b = 11.22–24.54, all P < 0.05) were also observed as VMS severity increased (with each b representing the difference between each level of severity and the reference category). Conclusion These results suggest a high prevalence of VMS in Western Europe. These symptoms are also associated with both humanistic and economic outcomes. Improved management of VMS may be able to increase the health status and ability to work productively as well as reduce societal direct costs.