Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Second-Generation Antiepileptic Drugs Compared to First-Generation Antiepileptic Drugs on Bone Metabolism in Patients with Epilepsy: A Meta-Analysis

Abstract We conducted this meta-analysis to evaluate effects of second-generation anti-epileptic drugs (AEDs; levetiracetam, lamotrigine) compared to first-generation AEDs (valproic acid, carbamazepine) on bone metabolism in epilepsy patients. PubMed, Web of Science, Clinical trials.gov, Wanfang, and China national knowledge infrastructure databases were searched. Ten trials were included. Results showed: (1) The overall SMD for changes of serum calcium, phosphorus, ALP, and PTH levels from baseline of LEV versus first-generation AEDs were 1.00 (95% CI=0.23–1.77, Z=2.56, p=0.01), 0.98 (95% CI=− 0.05 to 2.01, Z=1.86, p=0.06), − 1.17 (95% CI=− 2.08 to − 0.25, Z=2.50, p=0.01), 0.07 (95% CI=− 0.14 to 0.27, Z=0.63, p=0.53), respectively. (2) The overall SMD for changes of serum calcium, phosphorus, ALP, and PTH levels from baseline of LTG versus first-generation AEDs were −0.16 (95% CI=− 0.47 to 0.16, Z=0.99, p=0.32), −0.05 (95% CI=− 0.55 to 0.44, Z=0.22, p=0.83), 0.10 (95% CI=− 0.53 to 0.73, Z=0.31, p=0.75), −0.05 (95% CI=− 0.52 to 0.42, Z=0.22, p=0.83), respectively. Overall, our results indicate that compared to first-generation AEDs, LEV has less adverse effects on blood bone metabolism markers in epilepsy patients, while LTG does not. However, due to small number of included studies, our results warrant additional research.
Experiences of the older hospitalised person on nursing pain care: An ethnographic insight.

AIMS AND OBJECTIVES This paper presents an ethnographic insight into the older hospitalised person (those aged over 65 years) perceptions and experiences of pain care provision by nurses in acute care. BACKGROUND Pain care provision by nurses remains less than optimal for the older hospitalised person despite numerous evidence-based guidelines. There is a paucity of research providing input from the experiences of the older hospitalised person in relation to their perspectives of pain care provision by nurses in acute care. Pain care research needs more involvement from those older persons with documented diagnoses of dementia, delirium, or cognitive impairment, and intellectual disabilities and those in their end-stage of palliation. DESIGN A focused ethnographic study. The consolidated criteria for reporting qualitative research (COREQ) was used to report the findings of this study. METHODS A focused ethnographic study was conducted in 8 acute care units within 2 large tertiary referral hospitals on the East Coast of Australia. Consisting of semi-structured interviews (n= 12) of cognitively intact older persons (11 hours). Twenty-three (23) semi-structured interviews with nine (9) RN participants (12 hours and 38 minutes). Participant observation period totalled 1,041 hours. RESULTS The older persons experiences of receiving pain care was based on a formulaic assessment process focusing on intensity of pain and pain management options provided often lacked their input. The older persons often did not perceive their pain care provision as being of benefit to themselves. The nurses lacked insight and understanding on the nature of pain for the older person. CONCLUSION Understanding was gained into how the older persons pain care was hampered due to the lack of appropriate, and meaningful pain care provision and provides insight into why the older hospitalised person continues to experience a less than optimal experience. RELEVANCE TO CLINICAL PRACTICE Older hospitalised persons can gain continuity of pain care when nurses negotiate with them in order to repattern or restructure their nursing routines for pain care provision. Older people need inclusion into pain care decisions. All vulnerable older persons require nurses to use an evidence-based pain assessment tool. This article is protected by copyright. All rights reserved.
Dietary Inflammatory Index and Non-Communicable Disease Risk: A Narrative Review

There are over 1,000,000 publications on diet and health and over 480,000 references on inflammation in the National Library of Medicine database. In addition, there have now been over 30,000 peer-reviewed articles published on the relationship between diet, inflammation, and health outcomes. Based on this voluminous literature, it is now recognized that low-grade, chronic systemic inflammation is associated with most non-communicable diseases (NCDs), including diabetes, obesity, cardiovascular disease, cancers, respiratory and musculoskeletal disorders, as well as impaired neurodevelopment and adverse mental health outcomes. Dietary components modulate inflammatory status. In recent years, the Dietary Inflammatory Index (DII®), a literature-derived dietary index, was developed to characterize the inflammatory potential of habitual diet. Subsequently, a large and rapidly growing body of research investigating associations between dietary inflammatory potential, determined by the DII, and risk of a wide range of NCDs has emerged. In this narrative review, we examine the current state of the science regarding relationships between the DII and cancer, cardiometabolic, respiratory and musculoskeletal diseases, neurodevelopment, and adverse mental health outcomes. We synthesize the findings from recent studies, discuss potential underlying mechanisms, and look to the future regarding novel applications of the adult and children’s DII (C-DII) scores and new avenues of investigation in this field of nutritional research.
Gulp1 controls Eph/ephrin trogocytosis and is important for cell rearrangements during development

Trogocytosis, intercellular cannibalism distinct from phagocytosis, occurs when cells rearrange during development. Here, Gong et al. reveal that trogocytosis induced by ephrins and Eph receptors involves phagocytic adaptor protein Gulp1, Rac-specific guanine nucleotide exchange factor Tiam2, and endocytic GTPase dynamin. These results suggest that ephrin/Eph-induced trogocytosis uses phagocytosis-like mechanisms.
The psychosexual impact of testing positive for high‐risk cervical human papillomavirus (HPV): A systematic review

Many countries are implementing human papillomavirus (HPV)‐based cervical screening due to the higher sensitivity of the test compared with cytology. As HPV is sexually transmitted, there may be psychosexual consequences of testing positive for the virus. We aimed to review the literature exploring the psychosexual impact of testing positive for high‐risk cervical HPV.
Brown Adipocytes Secrete GDF15 in Response to Thermogenic Activation

Transcriptomic analysis of gene expression in brown adipose tissue (BAT) from mice in response to cold revealed strong induction of growth and differentiation factor 15 (GDF15). This study aimed to characterize GDF15 as a brown adipokine released in response to thermogenic activation and to determine its target functions.
Characteristics of circular RNA expression of pulmonary macrophages in mice with sepsis‐induced acute lung injury

Circular RNAs (circRNAs) make up a large class of non‐coding RNAs and play important roles in the pathology of a variety of diseases. However, their roles in pulmonary macrophage polarization after sepsisinduced lung injury is unknown. In this study, mice were divided into two groups: Sham control group and cecal ligation and puncture (CLP)‐induced ALI group. Macrophages were isolated from lung homogenates 24 hours after SCLP/CLP. We started with RNA‐seq of circRNA changes in macrophages and validated by RT‐PCR in the following experiments. A total of 4318 circRNAs were detected in the two groups. Of these, 11 and 126 circRNAs were found to be significantly upregulated and downregulated, respectively, compared to the control (p≤0.05, Fold Change ≥2). Differentially expressed circRNAs with a high foldchange (fold‐change >4, P<0.05) were selected for validation by qRT‐PCR, 10 of which were verified. Furthermore, the most differentially expressed circRNAs within all the comparisons were annotated in detail with circRNA/miRNA interaction information using miRNA target prediction software. The network of circRNA‐miRNA‐mRNA was illustrated by cytoscape software. Gene ontology analyses indicated the upregulated circRNAs were involved in the multiple biological functions such as regulation of mitochondrion distribution and Notch binding, while the down‐regulated circRNAs mainly involved in the biological process as histone H3K27 methylation. KEGG pathway analysis revealed TGF‐beta signaling pathway was related to the upregulated circRNAs. The present study provides a novel insight into the roles of circRNAs in pulmonary macrophage differentiation and polarization post septic lung injury.
Mushroom flavour

Abstract Mushrooms and fungi not only present a fascinating world of shapes, both macro- and microscopic, but they are also an interesting source of flavours, fragrances and odours, e.g. garlic, coconut, flour-like, cucumber or fruit-like, as well as the most characteristic for this kingdom of living organisms mushroom-like flavour and aroma. Fungi can possess many different and interesting flavours and fragrances - starting from nice anise-like, fruit-like, cucumber, garlic, to cheese-garlic, and ending with potato or flour-like smells. Some mushrooms emit carbide or distinctly faecal-like odour. The taste of mushrooms is frequently correlated with their aroma. What components does the core of a mushroom flavour consist of? Chemical analysis of specimens reveals compounds responsible for characteristic flavour and odour. It was found that the most characteristic flavour compound is defined mainly by C8 volatiles. Between all C8 compounds the most important for mushroom flavour are oct-1-en-3-ol, octan-3-ol, octan-3-on and oct-1-en-3-on. Fungi and mushrooms can enable biotechnological production of some flavour components, for instance the Nidula niveotomentosa produces a characteristic raspberries compound - raspberry ketone in submerged cultures; the biotechnological production can also provide rare and tasty forest mushroom biomass e.g. edible boletus. Streszczenie Grzyby w naszym otoczeniu stanowią nie tylko ciekawy świat kształtów, ale także są nośnikami ciekawych zapachów. Mykolodzy procujący z grzybami mikroskopowymi doskonale wiedzą, że niektóre z nich wydają charakterystyczną woń, jak np. woń czosnku typową dla rodzaju Mortierella lub kokosową w przypadku Trichoderma spp. W świecie grzybów spotkać można także takie zapachy, którym towarzyszy specyficzny smak. Któż nie zna typowego określenia „smak/aromat grzybowy”? Każdy, nawet osoba niezwiązana zawodowo z grzybami wie, co kryje się pod tym określeniem. Ale co stanowi, że możemy zdefiniować to określenie od strony chemicznej? Kluczową grupą substancji odpowiedzialnych za typowy smak i aromat grzybowy są lotne pochodne związków z grupy C8, a wśród nich najbardziej istotne okazują się być oct-1-en-3-ol, octan-3-ol, octan-3-on, oct-1-en-3-on. Grzyby dostarczają rozmaitych wrażeń zapachowych, począwszy od miłych anyżkowych, owocowych, poprzez ogórkowe, czosnkowe, serowo-czosnkowe, następnie przypominające ziemniaki lub mąkę, aż do zapachów nieprzyjemnych, jak zapach karbidu lub fekaliów. Smak niektórych z nich jest skorelowany z zapachem, w wielu przypadkach smaków nie znamy. Za każdym z tych aromatów ukrywają się związki chemiczne pozwalające czasem na uzyskanie wstępnej informacji taksonomicznej. Bogactwo aromatów w świecie grzybów pozwala na biotechnologiczne wykorzystanie ich do otrzymywania bądź to czystych związków, jak np. w przypadku ketonu malinowego pozyskiwanego z Nidula niveotomentosa, bądź np. aromatycznej grzybni mogącej zastąpić rzadkie i pożądane gatunki grzybów leśnych, np. borowików.
Metabolomic Differentials in Women With and Without Fibromyalgia

A nontargeted plasma metabolomic analysis was conducted to compare differentially expressed metabolites in women with and without fibromyalgia (FM) using data and samples collected from two parent studies in women with FM (n = 20) and comparative data collected from newly recruited age‐matched women (n = 20). Blood plasma samples were analyzed for metabolite content using liquid chromatography mass spectrometry. Consolidation of positive and negative ion mode metabolomics data with fold change (>2 or <0.5) and variable importance of projection scores ≥1 revealed statistically significant metabolites comparing samples from women with and without FM. Metabolite profiles in patients with FM differed from the comparison group in energy, lipid and amino acid metabolites reflecting heightened oxidative stress, inflammation, and tryptophan degradation in patients with FM. Study results may contribute to further identification of unique metabolomic profiles enhancing understanding of the pathophysiology of FM and for the development of effective therapeutic options.
Hsp70 and DNAJA2 limit CFTR levels through degradation

Cystic Fibrosis is caused by mutations in the CFTR anion channel, many of which cause its misfolding and degradation. CFTR folding depends on the Hsc70 and Hsp70 chaperones and their co-chaperone DNAJA1, but Hsc70/Hsp70 is also involved in CFTR degradation. Here, we address how these opposing functions are balanced. DNAJA2 and DNAJA1 were both important for CFTR folding, however overexpressing DNAJA2 but not DNAJA1 enhanced CFTR degradation at the endoplasmic reticulum by Hsc70/Hsp70 and the E3 ubiquitin ligase CHIP. Excess Hsp70 also promoted CFTR degradation, but this occurred through the lysosomal pathway and required CHIP but not complex formation with HOP and Hsp90. Notably, the Hsp70 inhibitor MKT077 enhanced levels of mature CFTR and the most common disease variant ΔF508-CFTR, by slowing turnover and allowing delayed maturation, respectively. MKT077 also boosted the channel activity of ΔF508-CFTR when combined with the corrector compound VX809. Thus, the Hsp70 system is the major determinant of CFTR degradation, and its modulation can partially relieve the misfolding phenotype.
Ultralow-Cost, Highly Sensitive, and Flexible Pressure Sensors Based on Carbon Black and Airlaid Paper for Wearable Electronics.

Flexible pressure sensors have attracted considerable attention because of potential applications in healthcare monitoring and human-machine interaction. However, the complicated fabrication process and costly sensing materials limit their widespread applications in practice. Herein, a flexible pressure sensor with outstanding performances is presented through an extremely simple and cost-efficient fabrication process. The sensing materials of the sensor are based on low-cost carbon black (CB) @ airlaid paper (AP) composites, which are just prepared by drop casting CB solutions onto APs. Through simply stacking multiple CB@APs with irregular surface and fiber-network structure, the obtained pressure sensor demonstrate an ultrahigh sensitivity of 51.23 kPa-1 and an ultralow detection limit of 1 Pa. Additionally, the sensor exhibits fast response time, wide working range, good stability, as well as excellent flexibility and biocompatibility. All the comprehensive and superior performances endow the sensor with abilities to precisely detect weak air flow, wrist pulse, phonation, and wrist bending in real time. In addition, an array electronic skin integrated with multiple CB@AP sensors has been designed to identify spatial pressure distribution and pressure magnitude. Through a biomimetic structure inspired by blooming flowers, a sensor with the open-petal structure has been designed to recognize the wind direction. Therefore, our study, which demonstrates a flexible pressure sensor with low cost, simple preparation, and superior performances, will open up for the exploration of cost-efficient pressure sensors in wearable devices.
The Effect of Zinc Supplementation on Serum Leptin Levels: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Abstract Recently, obesity has become a common worldwide concern. Leptin, as an adipocytokine, plays a major role in the etiology of obesity. Prior studies have demonstrated that zinc potentially affects serum leptin levels. However, clinical trials carried out in this regard are not consistent. Therefore, current meta-analysis was conducted to ascertain the actual effect of zinc supplementation on serum leptin levels in adults. Databases of PubMed, SCOPUS, and Google Scholar were methodically searched to identify relevant articles up to April 2018. Clinical trials that examined the effect of zinc supplementation on serum leptin concentrations as outcome variables in human adults were included. The mean difference (SD) of leptin changes in the intervention and placebo groups were used to calculate the overall effect size. Totally, 663 articles were identified, of which 6 studies were eligible randomized controlled trials (RCTs) with 7 treatment arms. The analysis suggested that zinc supplementation exerts no significant effect on overall serum leptin (WMD: 0.74 ng/ml; 95% CI: −1.39 to 2.87, p=0.49). Nevertheless, sex and duration of intervention seemed to impact the extent of zinc’s influence. In trials with female subjects, zinc consumption led to a significant decrease in serum leptin level (WMD: −1.93 ng/ml; 95% CI: −3.72 to −0.14, p=0.03) as well as trials that lasted for more than 6 weeks (WMD: −1.71 ng/ml; 95% CI: −3.07 to −0.35, p=0.01), in comparison to the control group. Zinc supplementation did not significantly improve leptin concentrations, but it may result in a decreased circulating leptin level in studies with a duration of more than 6 weeks especially among females.
Efficient job assignment in cloud system

Assigning jobs to servers in the case of datacenters is something that would preferably be done very efficient. According to theoretical analysis one big super server would be the most efficient. Even though this would the lowest expected sojourn time this is not likely nor feasible. Between systems where the dispatcher sends the job to one of the N servers upon arrival of the job the Join-the-Shortest-Queue system is the most efficient, unfortunately this system has a very big overhead at the dispatcher, and is therefore not the solution for the problem either. After Theoretical analysis and simulation it turns out to be efficient to work with tokens for servers that are idle (Join=the-Idle-Queue system), and combine this with a Power-of-d scheme in which d is low (1 or 2).
Revision control system and method

There is provided a file revision-control system, method and apparatus configured for storing and managing a revision history log, and for enabling to track and manage, compare and retrieve revisions including, current-revisions stored on a designated reference area, past-revisions stored in a predefined storage area and also past-revisions which were previously on a reference area. According to certain embodiments of the invention, each revision of a file is represented by a revision entry in a revision history log, which can be stored and managed in a designated data-repository. A revision entry stores data corresponding to at least one revision, while the revisions themselves may be stored on a designated data-repository. A progression path refers to one or more revision entries which represent the progression of a file over time. In case that a revision is branched into more than one revisions, each such revision will constitute a different progression path.
Weighted Correlation Network Analysis (WGCNA) Reveals the Hub Role of Protein Ubiquitination in the Acquisition of Desiccation Tolerance in Boea Hygrometrica.

The first genome sequenced resurrection plant Boea hygrometrica has been shown to be able to survive rapid air-drying after experiencing a slow soil-drying acclimation phase. Weighted gene co-expression analysis was used to study B. hygrometrica transcriptomic datasets. A network containing 22 modules was constructed and seven modules were found to be significantly related to desiccation response by enrichment analysis. Protein ubiquitination was observed to be a common process linked to hub genes in all seven modules. Ubiquitination modified proteins with diversified functions were identified using immunoprecipitation coupled to mass spectrometry. The lowest level of ubiquitination was noted at the full soil drying priming stage, which triggered the accumulation of protective protein BhLEA2. RY motif (CATGCA) was identified from the promoters of ubiquitination related genes that were down-regulated in the desiccated samples. In-silico analysis showed the negative regulation of ubiquitination related genes appeared to be mediated via a B3 domain-containing transcription repressor VAL1. This study suggests that priming may involve the transcriptional regulation of several major processes, and the transcriptional regulation of genes in protein ubiquitination may play a hub role to deliver acclimation signals to posttranslational level in the acquisition of desiccation tolerance in B. hygrometrica.
Governmental Financial Accounting and European Harmonisation: Case Study of Finland

Abstract The Finnish government accounting has developed from its own premises which used to emphasise the importance of budgetary accounting and prudence. Since the 1990s and the impact of New Public Financial Management, the Finnish government financial accounting has been accruals based. However, the Finnish application of accruals is based on the income statement approach, realisation principle and prudence. The International Public Sector Accounting Standards (IPSAS) based more on the balance sheet approach and fair value accounting are not suitable for the Finnish government accounting culture and practice. Furthermore, this means from the Finnish perspective that the EPSAS standards should not be based on IPSAS but on a conceptual framework especially developed for the European context.