Miracle-dz/UniFAR-FTUs huggingface dataset:
Trajectory control and vibration suppression of rigid‐flexible parallel robot based on singular perturbation method

To accurately, stably, and efficiently control the complex rigid‐flexible coupled robot, this paper takes Delta robot as the study object and decomposes it into slow subsystem and fast subsystem in different timescales by using singular perturbation principle, which the slow subsystem representing the rigid motion and the fast subsystem representing flexible vibration. In addition, the backstepping control system is designed for the slow subsystem, and the dynamic surface control system based on K‐observer is designed for the fast subsystem, and the overall control scheme is proposed by combining the backstepping control system and the dynamic surface control system, and the stability of the proposed overall control scheme is proven. Finally, the proposed control scheme is compared with proportional derivative control and trajectory control with workspace lattices, and the related experimental results are analyzed in details.
Period Multiplication in a Continuous Time Series of Radio-Frequency DBDs at Atmospheric Pressure

As a spatially extended dissipative system with strong nonlinearity, the radio-frequency (rf) dielectric-barrier discharges (DBDs) at atmospheric pressure possess complex spatiotemporal nonlinear behaviors. In this paper, the time-domain nonlinear behaviors of rf DBD in atmospheric argon are studied numerically by a onedimensional fluid model. Simulation results show that, under appropriate controlling parameters, the rf DBD can undergo a transition from single-period state to chaos through period doubling bifurcation with increasing discharge time, i.e., the regular periodic oscillation and chaos can coexist in a long time series of the atmosphericpressure rf DBD. With increasing applied voltage amplitude, the duration of the periodic oscillation reduces gradually and chaotic zone increases, and finally the whole discharge series becomes completely chaotic state. This is different from conventional period doubling route to chaos. Moreover, the spatial characteristics of rf perioddoubling discharge and chaos, as well as the parameter range of various discharge behaviors occurring are also investigated in this paper. PACS: 52.35. Kw, 52.65. Kj, 52.80. Pi
The roles of sex and gender in child and adolescent mental health

Abstract Neurodevelopmental and mental health disorders are common in children and young people, and frequently continue to be impairing into adulthood. Biological sex and gender identity are important factors in the likelihood of the development, referral and diagnosis of these disorders, as well as sources of clinical heterogeneity. In this editorial, we highlight that the aetiology of neurodevelopmental and mental health disorders in young people is complex and multi‐faceted. Emerging evidence has implicated sex and gender as playing an important role in understanding the onset and course of psychopathology in childhood and adolescence. Here, we underline the significance of continuing to actively study the roles of sex and gender in the context of outlining potential future research directions and understanding how best to support children and young people.
Criminal Justice System Processing and Victimization: Results from a Longitudinal Study of Males and Females

ABSTRACT There has been a great deal of interest in understanding the etiological underpinnings to victimization. This body of research has uncovered a list of risk factors that have been consistently tied to victimization. One of the more consistent results is that criminal offenders are at-risk for being victimized. The current study expanded on this finding by examining whether four measures of being processed through the criminal justice system (i.e., arrest, conviction, probation, and incarceration) were related to multiple measures of victimization in adolescence and adulthood. To do so, data from the National Longitudinal Study of Adolescent to Adult Health (Add Health) were analyzed. The results revealed consistent and statistically significant associations between the criminal justice processing variables and the victimization measures for both males and females even after controlling for self-reported criminal and delinquent involvement. We conclude by contextualizing the results and offering suggestions for future research in this area.
Un indicateur évaluant la diversité globale des rotations : de la diversité des cultures aux services écosystémiques

La diversification (allongement des rotations, introduction de cultures intermédiaires, cultures relais, associations…) est un des leviers majeurs pour une transition agroécologique des systèmes de culture. Cependant, toute diversification n’est pas bonne en soi car ses performances dépendent des cultures introduites et de la manière de les assembler. Pour aider les acteurs à orienter leur choix de configuration des systèmes de culture, nous avons développé un indicateur de diversité globale des cultures de la rotation (I-DGC) basé sur une construction en arbre hiérarchique. Celui-ci comprend une évaluation des diversités temporelle et spatiale. La diversité temporelle est ensuite décomposée en un indicateur de diversité taxonomique et un de diversité fonctionnelle, celle-ci étant liée à la fourniture de douze services écosystémiques (SE). L’indicateur global calculé à partir des données sur les cultures permet d’estimer a priori, l’effet potentiel de la diversification d’une rotation. L’estimation des douze SE sur un ensemble de rotations typiques des agroécosystèmes montre des variations importantes. Par ailleurs, l’allongement de la rotation et l’augmentation du nombre de cultures ne sont pas suffisants ; ils doivent être associés à un choix adéquat des cultures et de leur succession. Mots clés : transition agroécologique, diversification, diversité spatio-temporelle, succession cultures, association de culture, cultures en bandes
Chemical and Microstructural Properties of Designed Cohesive M-S-H Pastes

Concretes can be exposed to a magnesium attack in several environments leading to the formation of magnesium silicate hydrates (M-S-H) and brucite (MH). The formation of M-S-H is likely to alter the properties of the cement matrix because it is linked to the decalcification of C-S-H. However, relatively few data on M-S-H exist in the literature. In order to characterize, physically and mechanically, the M-S-H phase, pure M-S-H cohesive pastes are needed. This work studies the formation of cohesive M-S-H pastes made with MgO-to-SiO2 atomic ratios of 0.78, 1 and 1.3, from two types of silica (silica fume or colloidal silica) and under 20 °C and 50 °C thermal curing. X-ray diffraction and thermogravimetric analyses confirmed that the consumption of brucite and the formation of M-S-H were quicker with a 50 °C curing. Energy-dispersive X-ray spectroscopy and microtomography showed that colloidal silica enabled a better distribution of the particles than silica fume. Microstructural characterizations were conducted under the protocol with colloidal silica and 50 °C thermal curing. Porosity investigations allowed to describe the M-S-H pastes as highly porous materials with a low content of micropores in comparison with mesopores. The type of mixing influenced the mesopore size distribution.
Reevaluation of the role of LIP-1 as an ERK/MPK-1 dual specificity phosphatase in the C. elegans germline

Significance The RAS–ERK pathway is critical for metazoan development. In development, ERK activity is regulated by a balance of phosphorylation of ERK by MEK (MAPK kinase) and dephosphorylation by DUSPs (dual specificity phosphatases). LIP-1, a DUSP6/7 family member, was previously suggested to regulate MPK-1/ERK activity by dephosphorylating MPK-1 in the Caenorhabditis elegans germline, based on LIP-1's mutant phenotype in the germline and its DUSP role in vulval development. However, our investigations demonstrate that LIP-1 does not function as an MPK-1 DUSP in the germline and likely regulates germline functions through distinct targets. Our results present a cautionary note about misinterpreting similar mutant phenotypes caused by mutations in different genes and assuming that genes function similarly in different tissues. The fidelity of a signaling pathway depends on its tight regulation in space and time. Extracellular signal-regulated kinase (ERK) controls wide-ranging cellular processes to promote organismal development and tissue homeostasis. ERK activation depends on a reversible dual phosphorylation on the TEY motif in its active site by ERK kinase (MEK) and dephosphorylation by DUSPs (dual specificity phosphatases). LIP-1, a DUSP6/7 homolog, was proposed to function as an ERK (MPK-1) DUSP in the Caenorhabditis elegans germline primarily because of its phenotype, which morphologically mimics that of a RAS/let-60 gain-of-function mutant (i.e., small oocyte phenotype). Our investigations, however, reveal that loss of lip-1 does not lead to an increase in MPK-1 activity in vivo. Instead, we show that loss of lip-1 leads to 1) a decrease in MPK-1 phosphorylation, 2) lower MPK-1 substrate phosphorylation, 3) phenocopy of mpk-1 reduction-of-function (rather than gain-of-function) allele, and 4) a failure to rescue mpk-1–dependent germline or fertility defects. Moreover, using diverse genetic mutants, we show that the small oocyte phenotype does not correlate with increased ectopic MPK-1 activity and that ectopic increase in MPK-1 phosphorylation does not necessarily result in a small oocyte phenotype. Together, these data demonstrate that LIP-1 does not function as an MPK-1 DUSP in the C. elegans germline. Our results caution against overinterpretation of the mechanistic underpinnings of orthologous phenotypes, since they may be a result of independent mechanisms, and provide a framework for characterizing the distinct molecular targets through which LIP-1 may mediate its several germline functions.
Integrating Keyword Segmentation and Budget Allocation Decisions in Sponsored Search Advertising: An Exploratory Simulation Study

Budget constrained sponsored search advertisers must decide how to allocate their advertisement budget across ad campaigns and individual keywords. In this paper, a simulation model that integrates the complex issues involved in keyword segmentation and campaign organization is used to evaluate performance of various budget allocation strategies. Using the buying funnel model as the basis for keyword segmentation and campaign organization, we analyze Volume-based, Cost-based, and Clicks-based budget allocation strategies and evaluate their performance implications for different firms. The simulation model is empirically evaluated using four Fortune 500 companies and their keyword data obtained from a leading provider of keyword research technology. The results and statistical analyses show significant improvements in budget utilization using the proposed allocation strategies over a Baseline commonly used in practice. The study offers useful insights into the budget allocation problem by leveraging a theoretical framework for keyword segmentation and campaign management.
The European Medicines Agency Approved the New Antibacterial Drugs – Response to the 2017 Who Report on the Global Problem of Multi-Drug Resistance

Abstract The growing problem of antimicrobial resistance has been classified by the World Health Organization (WHO) as one of the top ten threats to mankind. In a special report published in 2017, the WHO presented a list of microorganisms for which the search for new therapeutic options is a priority. The highest (critical) priority was given to the search for new antibiotics active against carbapenem-resistant strains of Acinetobacter baumannii and Pseudomonas aeruginosa as well as against carbapenem- and third-generation-cephalosporin-resistant Enterobacterales strains (so-called critical priority pathogens). Whereas the second (high) priority was given among others to the search for new antibiotics active against methicillin- and vancomycin-resistant strains of Staphylococcus aureus (MRSA and VRSA) and vancomycin-resistant strains of Enterococcus faecium (VRE). Since the publication of the WHO report the European Medicines Agency has approved 6 novel, broad-spectrum antibiotics, from 6 different groups, addressing the priority pathogens to a different extent. Two of them are new combinations of carbapenems with non-β-lactam inhibitors of β-lactamases (active also against carbapenemases), belonging to two novel groups of inhibitors: diazabicyclooctanes (relebactam, combined with imipenem) and boronates (vaborbactam, combined with meropenem). The third new drug is a siderophore cephalosporin (cefiderocol) with an innovative mechanism of penetration into the bacterial cell. The next two antibiotics are the new fluoroquinolone (delafloxacin) and the new tetracycline (eravacycline), designed and synthesized to be more active than older members of these groups. The last innovative antibiotic is lefamulin – the first pleuromutilin approved for systemic use in humans. New approvals have expanded the number of available therapeutic options in the treatment of complicated urinary tract infections (meropenem/vaborbactam, cefiderocol), complicated intra-abdominal infections (meropenem/vaborbactam, eravacycline), nosocomial pneumonia (meropenem/vaborbactam, imipenem/relebactam), acute bacterial skin and skin structure infections (delafloxacin) and community-acquired pneumonia (lefamulin).
Alignment of spatial genomics and histology data using deep Gaussian processes

Spatially-resolved genomic technologies have allowed us to study the physical organization of cells and tissues, and promise an understanding of the local interactions between cells. However, it remains difficult to precisely align spatial observations across slices, samples, scales, individuals, and technologies. Here, we propose a probabilistic model that aligns a set of spatially-resolved genomics and histology slices onto a known or unknown common coordinate system into which the samples are aligned both spatially and in terms of the phenotypic readouts (e.g., gene or protein expression levels, cell density, open chromatin regions). Our method consists of a two-layer Gaussian process: the first layer maps the observed samples’ spatial locations into a common coordinate system, and the second layer maps from the common coordinate system to the observed readouts. Our approach also allows for slices to be mapped to a known template coordinate space if one exists. We show that our registration approach enables complex downstream spatially-aware analyses of spatial genomics data at multiple resolutions that are impossible or inaccurate with unaligned data, including an analysis of variance, differential expression across the z-axis, and association tests across multiple data modalities.
Conceptualizing the Contextual Dynamics of Safety Climate and Safety Culture Research: A Comparative Scientometric Analysis

Safety climate and safety culture are important research domains in risk and safety science, and various industry and service sectors show significant interest in, and commitment to, applying its concepts, theories, and methods to enhance organizational safety performance. Despite the large body of literature on these topics, there are disagreements about the scope and focus of these concepts, and there is a lack of systematic understanding of their development patterns and the knowledge domains on which these are built. This article presents a comparative analysis of the literature focusing on safety climate and safety culture, using various scientometric analysis approaches and tools. General development patterns are identified, including the publication trends, in terms of temporal and geographical activity, the science domains in which safety culture and safety climate research occurs, and the scientific domains and articles that have primarily influenced their respective development. It is found that the safety culture and safety climate domains show strong similarities, e.g., in dominant application domains and frequently occurring terms. However, safety culture research attracts comparatively more attention from other scientific domains, and the research domains rely on partially different knowledge bases. In particular, while measurement plays a role in both domains, the results suggest that safety climate research focuses comparatively more on the development and validation of questionnaires and surveys in particular organizational contexts, whereas safety culture research appears to relate these measurements to wider organizational features and management mechanisms. Finally, various directions for future research are identified based on the obtained results.
The application of the theory of social influence on the recruitment of Division I male basketball players

ABSTRACT The theory of social influence reveals how people may be influenced by others. The theory categorizes two general mechanisms: (a) informational social influence and (b) normative social influence. Friends and family members represent normative social influences, while informational influences may be gleaned from the broadcast and print media, Internet, or brochures. The results represented a departure from other studies as informational social aspects exerted more weight on the choice of schools by male basketball players than normative social items in this study. The authors posit the combination of information readily accessed on phones and computers, as well as the recruit’s technological savviness from a young age, require recruiters to devote more time to providing relevant and recent information about their program and school on the Internet and other informational outlets to be successful.
Can arrows change the subjective perception of space? Exploring symbolic attention repulsion

The attention repulsion effect (ARE) refers to distortions in the perception of space for areas near the focus of attention. For instance, when attending to the right-hand side of the visual field, objects in central vision may appear as though they are shifted to the left. The phenomenon is likely caused by changes in visual cell functioning. To date, research on the ARE has almost exclusively used exogenous manipulations of attention. In contrast, research exploring endogenous attention repulsion has been mixed, and no research has explored the effects of nonpredictive arrow cues on this phenomenon. This gap in the literature is unexpected, as symbolic attention appears to be a unique form of attentional orienting compared with endogenous and exogenous attention. Therefore, this study explored the effects of symbolic orienting on spatial repulsion and compared it with an exogenously generated ARE. Across four experiments, both exogenous and symbolic orienting resulted in AREs; however, the magnitude of the symbolic ARE was smaller than the exogenous ARE. This difference in magnitude persisted, even after testing both phenomena using stimulus timing parameters known to produce optimal effects in traditional attentional cueing paradigms. Therefore, compared with symbolic attention, it appears that exogenous manipulations may tightly constrict attention resources on the cued location, in turn, potentially influencing the functioning of visual cells for enhanced perceptual processing.
The relationship between systemic disorders and anatomical outcomes after Descemet membrane endothelial keratoplasty.

PURPOSE The aim of this study was to investigate the association of anatomical outcomes and medications of patients with systemic diseases who underwent Descemet membrane endothelial keratoplasty with donor factors. METHODS Sixty nondiabetic donors of endothelial grafts and 60 patients who underwent operation by a single surgeon were included in this retrospective study. The patients' data, including the presence of diabetes mellitus and hypertension, antidiabetic-antihypertensive medications, and intracameral tamponades and anatomical outcomes, were recorded. The donor data were obtained from eye bank records. RESULTS Eighteen patients had type 2 diabetes mellitus (30%) and 34 had hypertension (56.6%). Among the patients with diabetes mellitus, 13 were receiving a single-agent antidiabetic drug, 4 were receiving dual oral antidiabetic therapy, and 1 was receiving insulin therapy. Among the hypertensive patients, 11 had monotherapy and 23 had dual antihypertensive therapy. Postoperatively, 35 patients (58.3%) had an endothelial attachment, 8 (13.3%) received reinjection, 7 (11.7%) required re-Descemet membrane endothelial keratoplasty, and 10 (16.7%) underwent penetrating keratoplasty. The mean donor age was 51.2 ± 14.1 years. The most common cause of donor death was cardiopulmonary arrest (36/60 cases; 60.0%). Regression analysis revealed that the presence of diabetes mellitus significantly disrupted graft attachment (p=0.034), while the presence of hypertension, antidiabetic and antihypertensive medication use, and the type of tamponade used in the patients, and the age, sex, cause of death, and specular endothelial cell count of donors were not statistically significantly associated with graft attachment (p>0.05). CONCLUSION In this study, the anatomical outcomes of Descemet membrane endothelial keratoplasty surgery were affected by recipient and donor factors. The presence of diabetes mellitus in the recipient significantly negatively affected graft attachment.