Miracle-dz/UniFAR-FTUs huggingface dataset:
The similarity theory of physical simulation for space defense confrontation

The physical ground simulation of space defense confrontation is under the contractible time and space coordination of real world. The theoretical foundation of simulation is determined by the uniform constrains that ensured the similarities of geometrical and physical quantities mapping in the two spaces. Under the architectures of space vector linear similarity and time uniform elapse, the sufficient conditions of uniformity of geometrical and physical quantities are proved by the classical physics and mathematical induction. The further derivation inferred the invariance of the guidance methods within the two spaces. The results of mathematic simulation under the ideal conditions demonstrated the validity of the sufficient conditions of uniformity, which are the theoretical foundation of physical simulation of space defense confrontation.
Effects of Fentanyl with Levobupivacaine on Cognitive Functions and Cerebral Oxygenation

Preoperative risk assessment may fail in most patients who may be exposed to postoperative neurological sequelae. The aim of this study was to assess the effects of Fentanyl added to epidural levobupivacaine on cerebral oxygenation and cognitive functions. There was a negative correlation between age and MMT, and a positive correlation between SpO2 and MMT. MMT scores of Group 2 at postoperative first hour and fifth hours were lower than those of Group 1. It was concluded that while fentanyl added to epidural local anesthetic had no effect on hemodynamic parameters, SpO2, and right-left cerebral oxygen saturation, and although it may have caused a decrease in MMT scores in the early postoperative period, it did not cause impairment in cognitive functions.
Facile Synthesis of Nanostructured Carbon through Self‐Assembly between Block Copolymers and Carbohydrates

A simple and direct wet chemistry method is reported to simultaneously synthesize nanostructured carbon films and particles through self‐assembly of poly(styrene)‐poly(4‐vinylpyridine) (PS‐P4VP) and carbohydrate precursors (turanose, raffinose, glucose, etc.) in two fabrication processes—spin‐coating and aerosol processing. Starting with a homogeneous solution containing PS‐P4VP and carbohydrates, evaporation of solvent during either spin‐coating or an aerosol process leads to the formation of ordered mesostructured films and particles. High temperature treatment in argon atmosphere removes PS fragments, carbonizes carbohydrates and partial PVP fragments, and results in ordered nanoporous carbon films and particles. SEM, TEM, and GISAXS characterization indicates that these nanostructured carbon materials exhibit large nanopores (> 20 nm), controlled 1–3 dimensional structures, and controlled surface chemistry. Nitrogen sorption isotherms and electrochemistry characterization indicates the accessibility of the carbon nanopores to both gas phase and aqueous phase. Results suggest that the nanostructured carbon films and particles can be tuned through solvent annealing, precursor concentration, and choice of block copolymers used. These carbon materials present varied practical applications for sorption and separation, sensors, electrode materials, etc.
Haemostatic Mechanism in the Uterine Circulation during Placental Separation

The haemostatic mechanism in the uterus during parturition was investigated in 12 patients being delivered by caesarean section. Detailed sequential study of the blood coagulation and fibrinolytic systems in the uterine circulation showed that placental separation is accompanied by a striking local activation of the clotting mechanism. Uterine vein blood draining the placental site while the placenta was separating showed a pronounced shortening of the whole-blood clotting-time, a significant shortening of other clotting-tests, and a sharp increase in factor VIII activity, though these changes were transitory. After delivery the level of fibrinogen and circulating platelets steadily increased and factor VIII activity remained high. Activation of the clotting mechanism during placental separation appears to play an essential part in controlling uterine haemorrhage. The subsequent changes in the haemostatic mechanism in the puerperium are likely to predispose to thromboembolic complications.
The prevalence of glucose metabolism abnormalities in Greek women with polycystic ovary syndrome

The prevalence of glucose metabolism abnormalities in PCOS women worldwide varies between 10 and 40% but there are no data in Greek PCOS women. In this retrospective study the prevalence of glucose abnormalities and the indices of insulin resistance (IR) and whole-body insulin sensitivity were estimated in a Greek population with PCOS. Impaired glucose tolerance (IGT), impaired fasting glucose (IFG) and type 2 diabetes mellitus (t2DM) were calculated. The prevalence of IGT, IFG and t2DM in our PCOS population was 7.6, 5.1 and 1.7%, respectively. The total prevalence of glucose abnormalities was estimated as 14.1%. The prevalence of t2DM was three- to four-fold higher than in the general Greek female population of the same age as this was estimated by 2, recently published studies. PCOS women with increased BMI and waist circumference and age greater than 30 years, present more severe IR and decreased whole-body insulin sensitivity. Our data indicates a relatively high prevalence of glucose intolerance and t2DM in a Greek population with PCOS. Obese women with PCOS are in higher risk to develop glucose abnormalities and probably t2DM later in life and therefore every woman diagnosed with PCOS should undergo a 2-h post load OGTT.
Reduction of heart sounds from lung sound recordings by automated gain control and adaptive filtering techniques

Auscultation is an attractive, simple, and noninvasive method for the diagnosis of cardiovascular and pulmonary disorders. However, heart sounds contaminates severely lung sound recordings. The results of our previous researches indicated that the Laplacian electrocardiographic signal (LECG) could be used as a reference for adaptive filtering to reduce heart sounds. In this paper, an integrated platform including an electronic stethoscope, an automated gain control (AGC), and an adaptive algorithm, has been developed to process the signal in real time. The AGC algorithm allows amplifying the LECG signal in different scales to solve the problem of relatively weak LECG signals at the right chest. The experimental result shows that the heart-noise reduction at the right chest is improved from 43% reported early to 75%. The overall heart sound reduction by our new scheme ranges from 75% to 83% at different chest locations.
Object identification in simultanagnosia: When wholes are not the sum of their parts

Abstract We examined object identification in two simultanagnosic patients, ES and GK. We show that the patients tended to identify animate objects more accurately than inanimate objects (Experiments 1 and 4). The patients also showed relatively good identification of objects that could be recognised from their global shape, but not objects whose recognition depended on their internal detail (Experiment 2). Indeed, the presence of local segmentation cues disrupted global identification (Experiment 3). Identification was aided, though, by the presence of surface colour and texture (Experiment 4). We suggest that the patients could derive global representations of objects that served to recognise animate items. In contrast, they were impaired at coding parts-based representations for the identification of inanimate objects.
Hepatitis C Virus Nonstructural 5A Protein Interacts with Abelson Interactor 1 and Modulates Epidermal Growth Factor-mediated MEK/ERK Signaling Pathway*

The propagation of hepatitis C virus (HCV) is highly dependent on host cellular factors. To identify the cellular factors involved in HCV propagation, we have previously performed protein microarray assays using the HCV nonstructural 5A (NS5A) protein as a probe. Of ∼9,000 host proteins immobilized in a microarray, ∼90 cellular proteins were identified as HCV NS5A interacting partners. Of these candidates, we selected Abelson interactor 1 (Abi1) for further characterization. Binding of HCV NS5A to Abi1 was verified by both in vitro pulldown and coimmunoprecipitation assays. HCV NS5A interacted with Abi1 through regions I + II of Abi1 and domain I of NS5A. We further demonstrated that Abi1 colocalized with the HCV NS5A protein in the cytoplasm. We showed that NS5A inhibited epidermal growth factor-mediated ERK and Egr1 activations and this inhibitory activity of NS5A was nullified in Abi1-knockdown cells. Moreover, silencing of Abi1 expression impaired HCV replication, whereas overexpression of Abi1 promoted HCV propagation. Collectively, these data indicate that HCV exploits host Abi1 protein via NS5A to modulate MEK/ERK signaling pathway for its own propagation.
Adipose-derived stem cells (ADSC) in the viability of random skin flap in rats.

PURPOSE To evaluate the effects of the adipose-derived stem cells (ADSC) in the viability of random skin flap in rats. METHODS Thirty five adult male Wistar rats (weight 250-300 g) were used. ADSC were isolated from adult male rats (n=5). ADSC were separated, cultured and then analyzed. A dorsal skin flap measuring 10 x 4 cm was raised and a plastic barrier was placed between the flap and its bed. After the surgical procedure, the animals were randomized into two groups (n=15 each group), group control and group ADSC. In all groups the procedures were performed immediately after the surgery. The percentage of flap necrosis was measured on the seventh postoperative day. RESULTS The ADSC were able to replicate in our culture conditions. We also induced their adipogenic, osteogenic and chondrogenic differentiation, verifying their mesenchymal stem cells potentiality in vitro. The results were statistically significant showing that the ADSC decreased the area of necrosis (p<0.05). CONCLUSION The cells demonstrated adipogenic, osteogenic and chondrogenic differentiation potential in vitro. The administration of adipose-derived stem cells was effective to increase the viability of the random skin flaps in rats.
SEMANTIC SEARCH USING LATENT SEMANTIC INDEXING AND WordNet

Semantic Search and Information Retrieval forms an integral part of various Search Engines in use. Famous search engines such as, Yahoo, Google, Lycos etc. use the concept of semantic search, where the only comparator for the objects under study is semantic similarity between the objects. The general method involves document-to-document similarity search. This sort of search involves the sequential search of documents one after the other, which involves numerous noise effects. An efficient way of improving this technique is the Latent Semantic Indexing (LSI). LSI maps the words under study on a conceptual space. The conceptual space depends on the queries and the document collection. It uses a mathematical function to figure out the similarity between the words, something called as Singular Value Decomposition. It utilizes the words under study and the ones that are being compared and produces appropriate results. The results obtained are free of semantics like synonymy, polysemy etc. Integrating Word Net, a large lexical database of English language is an efficient way to increase the search result. The word under consideration is linked to the application and the semantic similarities of the word are found out. Documents similar to these similarities are then indexed and listed. The proposed model is tested with standard set of Forum for Information Retrieval (FIRE) documents and a comparison with the term based search has been done.
The Effect of Deliberate Play on Tactical Performance in Basketball

This field-based study analyzed effects of a deliberate-play training program in basketball on tactical game intelligence and tactical creativity. 22 youth basketball players, ages 10 to 12 years, completed basketball training in one of two equal-sized groups. The deliberate-play training program contained unstructured game forms in basketball. The placebo group played in traditional structured basketball game forms. Tactical intelligence and creativity was assessed before and after an 18-lesson intervention. Analysis showed significant training improvement only for the deliberate-play group. In addition, this outperformance of the placebo group was not only observed for tactical creativity but also for tactical intelligence.
The relative dosing of epoetin alfa and darbepoetin alfa in chronic kidney disease

ABSTRACT Objective: The purpose of this study was to review and analyze current research to evaluate the dose ratio of epoetin alfa and darbepoetin alfa for the treatment of anemia in chronic kidney disease (CKD) and to identify determinants of the variation in epoetin alfa: darbepoetin alfa dose ratios across studies. Methods: A systematic review of the literature for comparative switch and non-switch studies of epoetin alfa and darbepoetin alfa treatments in CKD for the period 2000–2005 was performed. Two reviewers independently assessed the quality of the information. Data on the study design and outcomes were collected for each selected study. The dose ratio from epoetin alfa to darbepoetin alfa was calculated for each study, and the results were reported stratified by study characteristics. To control for differences in study design and characteristics that could explain the variability in the relative dosages of the two agents across studies, multivariate regression analysis was conducted. Based on these results, a dose conversion ratio for Canada was estimated. Results: A total of 21 studies involving 16 378 patients exposed to epoetin alfa or darbepoetin alfa in CKD were identified. Univariate analysis of the dose ratios indicated a mean dose ratio of 217:1 (IU of epoetin alfa:µg of darbepoetin alfa). Results from the multivariate analysis demonstrated that the study design (i.e., switch study versus straight comparison studies) and geographical coverage (i.e., United States) affected the results. Based on the multivariate analysis, the dose conversion ratio between epoetin alfa and darbepoetin alfa for Canada was 169:1. Conclusions: Despite limitations associated with switching studies and the limited total number of studies available, this systematic review based on aggregated results provides further evidence to the clinical community that the dose conversion ratio for epoetin alfa:darbepoetin alfa in CKD patients in Canada is approximately 169:1. At that ratio, treatment with epoetin alfa is 11–18% cheaper than treatment with darbepoetin alfa in Canada.
Contrast-Enhanced Microcomputed Tomography Using Intraperitoneal Contrast Injection for the Assessment of Tumor-Burden in Liver Metastasis Models

Objectives:To determine if intraperitoneally (IP) administered contrast (iohexol), used in conjunction with a liver-specific agent (Fenestra), can improve measurement precision and accuracy when quantifying tumor volume from micro-CT images of a liver metastasis model. Materials and Methods:We compared images acquired with Fenestra alone to images acquired with the combination of Fenestra and IP iohexol. The variability in tumor volume and tumor-burden measurement was evaluated for both techniques. The tumor-burden measurement accuracy of both in vivo techniques was determined by comparison with tumor-burden quantified from ex vivo images. Results:The addition of IP iohexol decreased measurement variability for individual tumors and overall tumor-burden by 4–8 fold and 2–3 fold, respectively. IP iohexol significantly improved the accuracy of tumor-burden measurement for both low and high tumor-burdened animals. Conclusions:The combination of IP iohexol with Fenestra provides superior delineation of liver tumors, in comparison to Fenestra alone. The complete tumor delineation provided by this imaging strategy allows for noninvasive quantification of liver tumor-burden.
Is Type D Personality Here to Stay? Emerging Evidence Across Cardio- vascular Disease Patient Groups

textabstractThe distressed personality (Type D) is an emerging risk factor in cardiovascular disease (CVD) that incurs a risk on par with left ventricular dysfunction in patients with ischemic heart disease. Type D is defined as the co-occurring tendencies to experience increased negative emotions and to inhibit self-expression in social interactions. Evidence is accumulating that Type D may also be a risk factor for adverse outcome across CVD patient groups, including patients undergoing revascularization with drug-eluting stent implantation or bypass surgery, patients with heart failure, peripheral arterial disease, and arrhythmia. In these patient groups, Type D personality has been associated with a 2-5 fold increased risk of adverse prognosis, impaired quality of life and symptoms of anxiety and depression independent of traditional biomedical risk factors, including disease severity. Although little is known about the pathways responsible for the detrimental effects of Type D on clinical outcome, the immune system and health-related behaviors, such as smoking and noncompliance, are likely candidates. Further research is warranted to investigate whether Type D personality is here to stay as a risk factor for CVD, but weighing current evidence on Type D against a set of external criteria shows that Type D personality fulfills the majority of these criteria. Importantly, Type D can easily be assessed in clinical research and practice with the standardized and validated DS14.
Predictability in Unstable, Continuous Systems

Abstract : My long-term goal in this project is to improve our ability to predict environmental conditions using dynamical models. The central objective of my research in this project is to understand the mathematical and physical connections between the bred-growing-mode technique recently developed for numerical weather prediction, the Lyapunov vectors and exponents of dynamical systems theory, and the local instability theories of geophysical fluid dynamics. My intent is to gain insight into fundamental mathematical and physical aspects of predictability in unstable (irregular, chaotic) continuous systems.
The relationship between lower extremity closed kinetic chain strength & sagittal plane landing kinematics in female athletes.

BACKGROUND Female athletes continue to injure their anterior cruciate ligaments at a greater rate than males in comparable sports. During landing activities, females exhibit several different kinematic and kinetic traits when compared to their male counterparts including decreased knee flexion angles as well as decreased lower extremity (LE) strength. While open kinetic chain strength measures have not been related to landing kinematics, given the closer replication of movement patterns that occur during closed kinetic chain (CKC) activity, it is possible that lower extremity strength if measured in this fashion will be related to landing kinematics. PURPOSE To determine if unilateral isometric CKC lower extremity (LE) strength was related to sagittal plane tibiofemoral kinematics during a single leg landing task in competitive female athletes. We hypothesized females who demonstrated lesser CKC LE strength would exhibit decreased sagittal plane angles during landing. METHODS 20 competitive female athletes (age = 16.0 ± 1.8 yrs; height = 166.5 ± 8.3 cm; weight = 59.7 ± 10.2 kg) completed CKC LE strength testing followed by 5 unilateral drop landings on the dominant LE during one test session at an outpatient physical therapy clinic. Closed kinetic chain LE strength was measured on a computerized leg press with an integrated load cell while sagittal plane tibiofemoral kinematics were quantified with an electrogoniometer. RESULTS No significant relationships between absolute or normalized isometric CKC strength and sagittal plane landing kinematics were identified. CONCLUSIONS Closed kinetic chain lower extremity isometric strength tested at 25 degrees of knee flexion is not related to sagittal plane landing kinematics in adolescent competitive female athletes. LEVELS OF EVIDENCE Analytic, Observational.
Psychometric Evaluation of the Behavioral Health Questionnaire-20: A Brief Instrument for Assessing Global Mental Health and the Three Phases of Psychotherapy Outcome

This study evaluated the psychometric properties of the 4 scales of the Behavioral Health Questionnaire-20 (BHQ-20): Global Mental Health, Well-Being, Symptoms, and Life Functioning. Four samples were used: community adults, college students, college students in counseling, and adults in outpatient psychotherapy. Support was found for internal consistency and 2-week test-retest reliability. For construct validity, the BHQ-20 scales distinguished levels of pathology among the samples and were sensitive to improvement across 3 psychotherapy sessions. Concurrent validity correlations with the scales of established measures were at least moderately high. Higher correlations were also found between the BHQ-20 scales and the nonanalogous scales of the established measures. These results, along with high correlations among the BHQ-20 scales, indicated the presence of 1 primary mental health dimension accounting for the variance. The BHQ-20 was proven to be a generally reliable, valid questionnaire that is distinguished by the efficiency with which it assesses mental health.
Evolutionary Relationship of Genomic Insulin Sequence in Different Mammalian Species: A Computational Approach

Genomic insulin is located on the short arm of chromosome 11 in human genome. It is a well studied polypeptide hormone, consists of 110 amino acids which start with signaling peptide of 1-24 amino acids, B-chain of 25-54 amino acids, C-peptide of 55-89 amino acids and end with A-chain of 90-110 amino acids. Insulin, produced by the beta cell of the pancreas in response to glucose stimuli, binds to its receptor rapidly due to receptor autophosphorylation and primordially regulates nutritional metabolic pathways. In this study we have depicted and explored evolutionary conservation rate, insight into structure and phylogenetic connection of insulin molecule among eight mammalian species; Homo sapiens (Human), Bos taurus (Cattle), Cavia porcellus (Guinea pig), Canis lupus familiaris (Dog), Gorilla gorilla (Western gorilla), Ovis aries (Sheep), Pan troglodytes (Chimpanzee), Pongo pygmaeus (Orangutan) using Computational Biology. The analysis of physico-chemical characteristics, secondary and 3-D structure prediction of insulin in different species identified phylogenetically most related species. The major findings are that genomic insulin from Human and Dog has a lowest genetic distance of 0.13 of the mammalian species studied. Human and Guinea pig has the next lowest genetic distance of 0.39 and 69.1% identical at the amino acid level. Whereas Human and Western gorilla has genetic distances of 0.00 and 100% identical at the amino acid level and share a common node on the phylogenetic tree. Physico-chemical study also shows that these sequences show high leucine content (18.2%) with high instability index (>40) except Sheep and Cattle has low leucine and instability index (<40). The sequence analysis among species has allowed us to know the manner in which the insulin has evolved over million–year period. This study result provides rapid comprehensive information to calculate the amino acid sequences in relations to evolutionary conservation rates as well as molecular phylogenetics.