Miracle-dz/UniFAR-FTUs huggingface dataset:
Members against Dengue Virus Infection 2',5'-Oligoadenylate Synthetase Family Distinct Antiviral Roles for Human

The 2 (cid:1) ,5 (cid:1) -oligoadenylate synthetase (OAS) and its downstream effector RNase L play important roles in host defense against virus infection. Oas1b , one of the eight Oas1 genes in the mouse genome, has been identiﬁed as a murine ﬂavivirus-resistance gene. Four genes, OAS1 , OAS2 , OAS3 , and OAS- like ( OASL ), have been identiﬁed in the human OAS gene family, and 10 isoforms, including OAS1 (p42, p44, p46, p48, and p52), OAS2 (p69 and p71), OAS3 (p100), and OASL (p30 and p59) can be generated by alternative splicing. In this study, we determined the role of the human OAS/RNase L pathway in host defense against dengue virus (DEN) infection and assessed the antiviral potential of each isoform in the human OAS family. DEN replication was reduced by overexpression and enhanced by knockdown of RNase L expression, indicating a protective role for RNase L against DEN replication in human cells. The human OAS1 p42, OAS1 p46, and OAS3 p100, but not the other OAS isoforms, blocked DEN replication via an RNase L-dependent mechanism. Furthermore, the anti-DEN activities of these three OAS isoforms correlated with their ability to trigger RNase L activation in DEN-infected cells. Thus, OAS1 p42/p46 and OAS3 p100 are likely to contribute to host defense against DEN infection and play a role in determining the outcomes of DEN disease severity. The Journal of Immunology, 2009, 183: 0000–0000.
A statistical approach of Biochemical Screening with various Biofertilizers and inorganic NPK influence on Amaranthus polygonoids ( L.)

The utilization of Bio-Fertilizers has been increasing due to increase in awareness of health with changing lifestyles. The application of biofertilizers in agricultural practices ensures environmentally friendly and safe resultant in all aspects . A pot experiment conducted to investigate the effect of bio fertilizers individually and in combination with chemical fertilizer on Amaranthus polygonoids (L.). The objective of the present study is to screen the best combination of various bio fertilizers, inorganic NPK, vermicompost for getting favourable nutritional characteristics. The treatment includes ten treatments (T1-T10) with four replications. The plants samples were analysed with biochemical constituents such as total chlorophyll, protein, carbohydrates, and cellular levels of calcium & iron on 35 days old plants. Bio-fertilizers Cyanobacteria, Phosphobacteria and Azospirillum combined with half dose of inorganic fertilizer (NPK) T10has lead to enhancement of nutritional status of leafy vegetable Amaranthus polygonoids compared to control. The result showed that the treatment T3-T10 has significant increase in all the biochemical parameters of the study and the joint treatment T10 were most notable over the control T1 (without fertilizer). The data obtained was analysed using statistical analysis software and the means were obtained using one-way ANOVA analysis.
Institutional Knowledge at Singapore Management University Institutional Knowledge at Singapore Management University Privacy in context-aware mobile crowdsourcing systems Privacy in context-aware mobile crowdsourcing systems

—Mobile crowd-sourcing can become as a strategy to perform time-sensitive urban tasks (such as municipal monitoring and last mile logistics) by effectively coordinating smartphone users. The success of the mobile crowd-sourcing platform depends mainly on its effectiveness in engaging crowd-workers, and recent studies have shown that compared to the pull-based approach, which relies on crowd-workers to browse and commit to tasks they would want to perform, the push-based approach can take into consideration of worker’s daily routine, and generate highly effective recommendations. As a result, workers waste less time on detours, plan more in advance, and require much less planning effort. However, the push-based systems are not without drawbacks. The major concern is the potential privacy invasion that could result from the disclosure of individual’s mobility traces to the crowd-sourcing platform. In this paper, we ﬁrst demonstrate speciﬁc threats of continuous sharing of users locations in such push-based crowd-sourcing platforms. We then propose a simple yet effective location perturbation technique that obfuscates certain user locations to achieve privacy guarantees while not affecting the quality of the recommendations the system generates. We use the mobility traces data we obtained from our urban campus to show the trade-offs between privacy guarantees and the quality of the recommendations associated with the proposed solution. We show that obfuscating even 75% of the individual trajectories will affect the user to make another extra 1.8 minutes of detour while gaining 62.5% more uncertainty of his location traces.
INVOL VEMENT OF MACROPRAGES IN REGULATING BORRELIA BURGDORFERl INFECTION

Numerous in vitro studies have suggested that macrophages actively phagocytize Borrelia burgdoiferi, the agent of Lyme disease, however; their role in clearance of these bacteria from infected animals has not been established. We evaluated the role of macrophages in regulating the hematogenous dissemination of B. burgdorferi in mice. Splenic and liver macrophages were eliminated by intravenous delivery of liposomeentrapped dichloromethylene diphosphonate (L-CI2MDP). Results indicated that macrophage depletion had no influence on the development of infection as determined by immunoglobulin production and arthritis severity. PCR detection of B. burgdoiferi DNA indicated the presence of spirochetes in ears, ankles, and hearts of all infected mice, with no significant differences observed in B. burgdoiferi numbers from macrophage depleted or control animals. PCR analysis of blood from B. burgdorferi infected mice suggests that macrophage depletion might promote an early blood-borne spreading of B. burgdoiferi, as mice treated with L-CI2MDP expressed a clear early dissemination 5 days postinfection and, to a lesser extent, at 10 days following infection. However, in other experiments equivalent levels of B. burgdoiferi were detected in blood of infected mice at different tinle points, regardless of the treatment they had received. In summary, depletion of macrophages from the liver and spleen does not influence the progression of Lyme disease pathology nor the abundance of spirochetes in tissues. Resident macrophages might play an important role in controlling spirochete dissemination in early stages of disease; however B. burgdoiferi in later stages are able to restore their ability to disseminate to targeted tissues, possibly by migration through tissues rather than dissemination by blood.
Технологія і безпека продуктів харчування / Technology and safety of food products

The article presents the results of studying how the storage duration and conditions effect on changes in the quality of the mushrooms Agaricus bisporus of the strain IBK-25 and Pleurotus ostreatus of the strain NK-35. The changes in the quality of mushrooms were estimated before and after 6 days of storage by sensory, commercial (marketability), and chemical parameters. The temperatures of storage were -1, +1, +3 and +5°C, and the relative humidity was 90±1%. The quality of products was evaluated by their appearance, natural loss, output of marketable mushrooms, and by chemical parameters: the content of dry matter, protein nitrogen and ascorbic acid. The results of visual observations for 6 days have shown that the best storage temperature for mushrooms was 1°C. At -1°C, the Agaricus bisporus froze and were not suitable for use after defrosting, while the Pleurotus ostreatus restored their structure and, after sorting, could be processed. During 6 days of storage at 3°C, the quantity of marketable Agaricus bisporus decreased by 3.4 and 3.5% (depending on the flush), that of Pleurotus ostreatus by 3.4 and 3.8%, compared with the reference. At 5°C, the Agaricus bisporus decreased in the quantity of marketable mushrooms by 19.2 and 20.6%, and the Pleurotus ostreatus by 12.4 and 13.1%. After 6 days of storage at 5°C, the natural loss of the Pleurotus ostreatus was greater than that of the Agaricus bisporus mushrooms (as a result of their larger evaporation area), but nonmarketable Pleurotus ostreatus mushrooms were fewer (8.7–9.9%, compared with 17.7–19.3% of the Agaricus bisporus). At 1°C, the output of marketable mushrooms in both species was about the same, but at 5°C, it was higher by 9.0–9.4% in the Pleurotus ostreatus. Six days of storage changed the contents of some chemical substances in the Agaricus bisporus: dry matter and ascorbic acid decreased by 5.3– 17.4% and by 7.4–25.9% respectively, though natural loss remained almost unchanged. Similar trends were observed in the Pleurotus ostreatus. Thus, as a result of our research, we recommend 1°С as the optimum temperature of storing Agaricus bisporus and Pleurotus ostreatus mushrooms, because it ensures retention of their sensory, marketability, and chemical parameters.
Topology perserving mappings using cross entropy adaptation

In this paper, we review the technique of Cross Entropy and apply it in a novel manner to the creation of topology preserving mappings. We create an underlying latent space which is mapped into data space by mapping the latent points through a number of basis functions and then linearly combining the output of these basis functions to create centres or prototypes in data space. In this paper, we use the cross entropy method for adapting the parameters of this linear combination matrix. We further show that the method can be extended to deep architectures, architectures with multiple layers of adaptive units which can be used to try to create more interesting features than can be found with one adaptive layer.
Maita Researching International PhD Algerian Students’ Communication Challenges in Speaking When Discussing and Interacting with Their British Peers: A Researcher’s Interpretive Perspective through the Use of Semi-Structured

 Abstract — This paper addresses the issue of the speaking challenges that the Algerian PhD students experience during their studies abroad, particularly in UK territory; more specifically, this study describes how these students may deal with such challenges and whether the cultural differences is one core reason in such dilemma or not. To this end, an understanding and interpretation of what actually encompasses both linguistic interference and cultural differences are required. Throughout the paper there is an attempt to explain the theoretical basis of the interpretive research and to theoretically discuss the pivotal use of the interview, as a data collection tool, in interpretive research. Thus, the central issue of this study is to frame the theoretical perspective of the interpretive research through the discussion of PhD Algerian’s communication and interaction challenges in the EFL context. This study is a corner stone for other research studies to further investigate the issue related to communication challenges because no specific findings will be pointed out in this
Mar 10, 2020 Toward industrial production of isoprenoids in Escherichia coli: Lessons learned from CRISPR-Cas9 based optimization of a chromosomally

Escherichia coli has been the organism of choice for the production of different chemicals by engineering native and heterologous pathways. In the present study, we simultaneously address some of the main issues associated with E. coli as an industrial platform for isoprenoids, including an inability to grow on sucrose, a lack of endogenous control over toxic mevalonate (MVA) pathway intermediates, and the limited pathway engineering into the chromosome. As a proof of concept, we generated an E. coli DH1 strain able to produce the isoprenoid bisabolene from sucrose by integrating the cscAKB operon into the chromosome and by expressing a heterologous MVA pathway under stress-responsive control. Production levels dropped dramatically relative to plasmid-mediated expression when the entire pathway was integrated into the chromosome. In order to optimize the chromosomally integrated MVA pathway, we established a CRISPR-Cas9 system to rapidly and systematically replace promoter sequences. This strategy led to higher pathway expression and a 5-fold improvement in bisabolene production. More interestingly, we analyzed proteomics data sets to understand and address some of the challenges associated with metabolic engineering of the chromosomally integrated pathway. This report shows that integrating plasmid-optimized operons into the genome and making them work optimally is not a straightforward task and any poor engineering choices on the chromosome may lead to cell death rather than just resulting in low titers. Based on these results, we also propose directions for chromosomal metabolic engineering. This article is protected by copyright. All rights reserved
Aspergillosis: A Life-Threatening Mycotic Disease of Humans and Animals

Editorial There are several mycotic diseases, such as cryptococcosis, candidiasis, aspergillois, histoplasmosis, sporotrichosis, fusariosis, maduromycosis, blastomycosis, coccidioidomycosis, chromoblas-tomycosis, rhodotoruliosis, paracoccidioidomycosis, geotrichosis, pneumocystosis, zygomycosis, penicillosis Marneffei, dermatophy-tosis, and others, which are reported from developed and develop-ing nations of the world [1]. Among these, aspergillosis is a highly infectious life threatening global mycotic disease of humans as well as animals including birds. The disease is important from public health and economic point of view. The association of Aspergillus fumigatus with keratitis in a buffalo calf and A.niger with abortion in a dairy was established for the first time by Pal 1983 1988, respectively Disseminated terreus infection in a caged was reported for the first time in India by Pal 1992. first Aspergillus to describe the first tory Aspergillus
Global social work

Some innovative and replicable aspects about the main contents of one educational program for social workers in Spanish are presented. The program is based on the critical analysis of implicit models and the development of intercultural competences. Our Intercultural Social Intervention Model (ISIM) is the central axis (theoretical and practical) of the educational program, which is used and inspired by other practice theoretical models and perspectives from the south and the north: concientización or consciousness raising model, anti-oppressive model, empowerment and advocacy model, and the transformative mediation model; though adapted to multicultural realities with more complexity and diversity than those in which the mentioned models developed. It is an international postgraduate program which is open to final-year bachelor students of social work. The program combines remote instruction (off-line and online activities) and on-campus activities (face-to-face online classes and workshops, practices in the field, collaborative groups, etc.).
COMPUTATIONAL TECHNIQUES FOR DATA SCIENCE APPLIED TO BROADEN THE KNOWLEDGE BETWEEN CITIZEN SCIENCE AND EDUCATION

This paper describes a preliminary study of how computational methods allow us to know more about citizen science and its connection with education. Citizen science is a practice involving a general public in scientific tasks and generating knowledge and scientific results. Previous studies have shown that the education sector can take benefit of the knowledge and activities organized or resources generated in CS projects. Previous studies have shown that the education sector can take advantage of the knowledge and activities organized in CS projects. In this papers, we analyze three citizen science platforms (Eu.Citizen science platform, Observatorio de la ciencia ciudadana and Oficina de la ciència ciutadana) with computational analytics techniques to provide initial insights of how educators can take benefit of the analysis of large amounts of data from CS. Finally, different visualizations and dashboards have been developed as illustrative examples of tools to support educators and learners. These tools provide information about citizen science projects, an overview of scientific vocabulary, access to validated resources and examples of technology used in scientific inquiry that can be used with educational purposes.
Clustering with Semantic Similarity for Text Mining

: Text processing plays a significant role in information retrieval, data mining and web search. Semantic similarity is used to analyse the relationship between word-pairs. The High-quality information is derived from mined text data through the devising of patterns. It is necessary to organize large amounts of unstructured text documents into a small number of conceptual clusters. Mining Text involves the pre-processing of document collections, text categorization and classification, extracting information and term from data sets. This work proposes a lexical pattern extraction technique to retrieve documents based on the user query and to find semantic relations that exist between the web documents. Coefficient measures are used to measure the similarity between the document sets. The Similarity measures are evaluated on various real world data sets for text classification and clustering problems.
Estimators usEd in thE nEw mExico invEntory: Practical imPlications of “truly” random nonrEsPonsE within Each stratum

—The annual forest inventory of New Mexico began as an accelerated inventory, and 8 of the 10 Phase 2 panels were sampled between 2008 and 2011. The inventory includes a large proportion of nonresponse. FIA’s estimation process uses post-stratification and assumes that nonresponse occurs at random within each stratum. We construct an estimator for the New Mexico inventory and derive an estimated variance based on the missing-at-random assumption.
The Inﬂuence of Large-Scale Climate Variability on Winter Maximum Daily Precipitation over North America

The generalized extreme value (GEV) distribution is ﬁtted to winter season daily maximum precipitation over North America, with indices representing El Nin˜o–Southern Oscillation (ENSO), the Paciﬁc decadal oscillation (PDO), and the North Atlantic Oscillation (NAO) as predictors. It was found that ENSO and PDO have spatially consistent and statistically signiﬁcant inﬂuences on extreme precipitation, while the inﬂuence of NAO is regional and is not ﬁeld signiﬁcant. The spatial pattern of extreme precipitation response to large-scale climatevariabilityissimilartothatoftotalprecipitationbutsomewhatweakerintermsofstatisticalsigniﬁcance. An El Nin˜o condition or high phase of PDO corresponds to a substantially increased likelihood of extreme precipitation over a vast region of southern North America but a decreased likelihood of extreme precipitation in the north, especially in the Great Plains and Canadian prairies and the Great Lakes/Ohio River valley.
DETERMINING THE BEST ANNUAL RAINFALL INTERPOLATION FOR BILA WALANAE WATERSHED

Bila Walanae watershed is the largest watershed in South Sulawesi. Water resources management need to take sedimentation analysis into account. However, using USLE as sedimentation analysis requires annual precipitation data in a spatial form. On the other hand, there are many methods of spatial interpolation. The purpose of this study was to determine the best spatial interpolation method for annual rainfall Bila Walanae watershed. Monthly rainfall data from 41 observation points (14 inside watershed, 27 around outside) were used. This study compares four methods of spatial interpolations, such as Inverse Distance Weight (IDW), Thin Plate Spline (TPS), Ordinary Kriging (OK), and modified Regression Kriging (MRK). Additional data for MRK derived from TRMM rainfall estimates (2013-2014) and GPM (2015-2017). Interpolation parameters such as pixel size and variogram models determined in advance while number of neighbour (NN) is 14. Two IDW power (1 and 2) and five TPS regularization setting (1E-5, 1E-4 1E-3, 1E-2 and 1E-1) is used. Error is generated through the leave-one-out cross validation by calculating RMSE and MAE. Result shows that TPSE-1 generate small error with highest correlation (MAE=648; RMSE=799; r=0.45) followed by IDW (646;799;0.40), OK (666;810;0.43), and then MRK (1410;3176;-0.11). Disuse of outside points increases MAE about 9%. Result of TPSE-1 interpolation is then averaged over five years and compared with land cover. Relatively high annual rainfall pattern is seen in area with forest in southern part of the watershed and around Lake Tempe that has no forest. Projections RCP by 8.5 shows increasing precipitation pattern in those area. Therefore, further studies related to priority of those two regions are needed.
Electromagnetic field generated by a wireless energy transfer system: comparison of simulation to measurement

Abstract This paper presents a wireless energy transfer system operating at the frequency values of kHz order: modeling, simulation, and comparison with prototype measurement results. Wireless energy transfer system model using finite element method was carried out to simulate the electric field and the magnetic flux density for different air gap sizes between the transmitter and the receiver coils. Results are presented and compared with the electromagnetic emission measurements radiated by the wireless energy transfer system prototype. The electric field comparison between the simulated and the prototype measurement values shows an error of roughly 8.7%. In the recent years, the interest in the wireless energy transfer technology, especially for electric vehicles batteries charging, is rapidly increasing. As a result of the increasing application of this technology in the industrial and consumer electronic products, more concerns are raised about the electromagnetic compatibility, since the wireless energy transfer systems produce electromagnetic emissions in the surrounding environment.
Prognosis of Thoracic Cancer Using the Bierman Random Committee Machine Learning

Thoracic most cancers are a prime problem in the clinical field. Unexpected occur-ring cannot be predicted earlier but if the strategy is fine-tuned properly then the prognosis of cancer is not a major issue. But the problem is how to find out the proper layout with all possible features. The sector of Thoracic Surgery is offering a source of the dataset with all feasible attributes of thoracic cancer. All the features suggested by this medical sector were approved by the Consortium of Tuberculosis and Pulmonary Diseases. The random committee is a novel hybrid algorithm that utilizes the benefit of both random forests with committee concepts. Many random forests are created as the result of the iteration. But anyone can be created and the committee analyses and retains any one optimal solution. Brei man, the first researcher to propose the general concept of Radio Frequency following the same he proposed the famous and most popular forest RF algorithm.