Miracle-dz/UniFAR-FTUs huggingface dataset:
Microstructure and Properties of Ni–Co Composite Cladding Coating on Mould Copper Plate

In this study, a Ni–Co composite coating was fabricated successively on a copper substrate by laser, and the microstructure and properties of the composite coating were studied. Our results show that the elements from Ni and Co alloy powder were uniformly distributed in the binding region, which obtained a good metallurgical bonding with the substrate. The microhardness of Co-based coatings was 646 HV0.1, which was approximately 7.6 times greater than the hardness of Cu substrate. The Ni-based coating hardness was a little lower than that of the Co-based coating, which was approximately 7.0 times higher than the hardness of Cu substrate. The Co-based coating was comprised of reinforced phases, such as Co, Ni–Cr–Co–Mo, M7C3 and {Fe, Ni}. The wear volume of Co-based coatings was approximately 0.164 mm3 after the sliding wear test at 60 min, which was only 4% of the substrate’s wear volume. Meanwhile, the heat shock resistance experiment was carried out at 800 °C for 75 times before the Ni–Co composite coating was peeled off. It was shown that this Ni–Co composite coating had good wear resistance and high temperature properties, which is helpful to improve the service life of a mould copper plate. It not only saves the economic cost of steel plants, but also improves the quality of slabs and products.
Neurocognitive Assessment and Retinal Thickness Alterations in Alzheimer Disease: Is There a Correlation?

BACKGROUND The relation of retinal thickness to neuropsychological indexes of cognitive impairment in patients with Alzheimer disease (AD) remains an area of investigation. The scope of this investigation was to compare volume and thickness changes of neuronal retinal layers in subjects with AD with those of age-matched healthy controls and to estimate the relation between cognitive functioning evaluated by neuropsychological assessment and thickness changes of the retina. METHODS This was a prospective single-site study where we evaluated 25 subjects with probable AD matched for age, sex, and education to 17 healthy control subjects (HC). All participants underwent a full medical evaluation, neuropsychological assessment, and optical coherence tomography (OCT) to evaluate the peripapillary retinal nerve fiber layer (pRNFL) thickness, ganglion cell complex (GCC) thickness, and macular volume. RESULTS The pRNFL thickness of AD patients showed a significant overall reduction compared with healthy controls (P = <0.0001). Furthermore, pRNFL was reduced in each retinal quadrant, particularly the inferior, nasal, and superior quadrants. GCC thickness and macular volume were reduced in AD patients in comparison with HC (P = 0.004; P = 0.001). Of particular interest was the correlation between OCT findings and neuropsychological assessment; we did not find a significant association of retinal thinning with worse MMSE score, but reduction of macular volume was associated with worse constructional praxis performance. Impairment of semantic-lexical and processing speed was associated with attenuation of macular GCC thickness. CONCLUSIONS OCT can show early thickness changes in AD patients with subtle memory disturbances. These results suggest that correlations between retinal thinning and cognitive performance warrant further investigation.
Wideband RCS Reduction Using Coding Diffusion Metasurface

This paper presents a radar cross-section (RCS) reduction technique by using the coding diffusion metasurface, which is optimised through a random optimization algorithm. The design consists of two unit cells, which are elements ‘1’ and ‘0’. The reflection phase between the two-unit cells has a 180° ± 37° phase difference. It has a working frequency band from 8.6 GHz to 22.5 GHz, with more than 9 dB RCS reduction. The monostatic RCS reduction has a wider bandwidth of coding diffusion metasurface as compared to the traditional chessboard metasurface. In addition, the bistatic performance of the designed metasurfaces is observed at 15.4 GHz, which shows obvious RCS reduction when compared to a metallic plate of the same size. The simulated and measured result shows the proficiency of the designed metasurface.
Establishing a framework for listening to children in healthcare

The principle that children and young people are capable of forming their own views, have the right to express those views, and are entitled to have those views taken seriously was introduced by the United Nations Convention on the Rights of the Child (UNCRC) in 1989. The implications for the delivery of healthcare are clear; however, children and young people continue to experience difficulty in having their views heard and taken seriously during healthcare encounters and the effectiveness of the UNCRC, in particular Article 12 appears to be limited. This article will discuss how, 30 years on, significant barriers continue to impede the full implementation of Article 12. In recognition of the limited awareness of its scope or even existence by health professionals working with children, a framework that can facilitate a better understanding of the concept of voice, and articulate healthcare organisations’ full responsibilities when it comes to Article 12, is presented.
Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer’s disease animal model

Objective Cerebral amyloidosis and severe tauopathy in the brain are key pathological features of Alzheimer’s disease (AD). Despite a strong influence of the intestinal microbiota on AD, the causal relationship between the gut microbiota and AD pathophysiology is still elusive. Design Using a recently developed AD-like pathology with amyloid and neurofibrillary tangles (ADLPAPT) transgenic mouse model of AD, which shows amyloid plaques, neurofibrillary tangles and reactive gliosis in their brains along with memory deficits, we examined the impact of the gut microbiota on AD pathogenesis. Results Composition of the gut microbiota in ADLPAPT mice differed from that of healthy wild-type (WT) mice. Besides, ADLPAPT mice showed a loss of epithelial barrier integrity and chronic intestinal and systemic inflammation. Both frequent transfer and transplantation of the faecal microbiota from WT mice into ADLPAPT mice ameliorated the formation of amyloid β plaques and neurofibrillary tangles, glial reactivity and cognitive impairment. Additionally, the faecal microbiota transfer reversed abnormalities in the colonic expression of genes related to intestinal macrophage activity and the circulating blood inflammatory monocytes in the ADLPAPT recipient mice. Conclusion These results indicate that microbiota-mediated intestinal and systemic immune aberrations contribute to the pathogenesis of AD in ADLPAPT mice, providing new insights into the relationship between the gut (colonic gene expression, gut permeability), blood (blood immune cell population) and brain (pathology) axis and AD (memory deficits). Thus, restoring gut microbial homeostasis may have beneficial effects on AD treatment.
RON2, a novel gene in Babesia bigemina, contains conserved, immunodominant B-cell epitopes that induce antibodies that block merozoite invasion

Abstract Bovine babesiosis is the most important protozoan disease transmitted by ticks. In Plasmodium falciparum, another Apicomplexa protozoan, the interaction of rhoptry neck protein 2 (RON2) with apical membrane antigen-1 (AMA-1) has been described to have a key role in the invasion process. To date, RON2 has not been described in Babesia bigemina, the causal agent of bovine babesiosis in the Americas. In this work, we found a ron2 gene in the B. bigemina genome. RON2 encodes a protein that is 1351 amino acids long, has an identity of 64% (98% coverage) with RON2 of B. bovis and contains the CLAG domain, a conserved domain in Apicomplexa. B. bigemina ron2 is a single copy gene and it is transcribed and expressed in blood stages as determined by RT-PCR, Western blot, and confocal microscopy. Serum samples from B. bigemina-infected bovines were screened for the presence of RON2-specific antibodies, showing the recognition of conserved B-cell epitopes. Importantly, in vitro neutralization assays showed an inhibitory effect of RON2-specific antibodies on the red blood cell invasion by B. bigemina. Therefore, RON2 is a novel antigen in B. bigemina and contains conserved B-cell epitopes, which induce antibodies that inhibit merozoite invasion.
Speech polar plots for different directionality settings of SONNET cochlear implant processor

Objectives: The newest CI processor from MED-EL company, the SONNET, has two new directional microphone settings. Besides the Omnidirectional microphone mode, it has the possibility to switch to Natural or Adaptive directionality. Both new modes favour perception of sound coming from a front-facing direction compared to sounds from sources at alternate azimuths. Natural directionality mimics the pinna effect of the normal external ear. Design: We undertook to verify the effect of these options in vivo by means of clinical audiological tests. Speech reception thresholds were successively measured for a variety of speech presentation azimuths while keeping the noise azimuths constant. Complete ‘Speech Reception Threshold (SRT)-Polar-Plots’ were obtained from these data for the Omnidirectional and Natural directionality modes of the SONNET. In addition, one ‘SRT-point’ was also measured in the ‘Adaptive’ mode for speech coming from 45° azimuth. Study sample: A group of 13 adult CI recipients participated. Only one of these subjects had previous experience with the SONNET processor. Results: Complete ‘SRT-Polar-Plots’ could be measured in Natural and Omnidirectional modes in CI recipients within an acceptable timeframe. The pinna-following directionality for Natural mode could be confirmed. Median SRT in noise for speech coming from the 45° azimuth speaker was −5.6 dB SNR for Omnidirectional, −9.1 dB SNR for Natural and −12.8 dB SNR for Adaptive microphone. Natural and Adaptive significantly improved performance compared to Omnidirectional mode at this optimal azimuth of 45° with a median improvement in SRT of 3.5 and 7.2 dB respectively. Conclusions: A novel audiological method, ‘SRT-Polar-Plot’, was developed and described. Significant directionality benefits for Natural and Adaptive mode were confirmed in vivo using this technique.
Influence of Binder Property and Mortar Thickness on High-Temperature Performance of Cold Recycled Mixtures with Asphalt Emulsion

Four kinds of cold recycling (CR) mixtures with different asphalt emulsions were studied for their high-temperature performance in both binder properties and internal structures aspects. Digital image processing was introduced to determine the thickness spectrum for the asphalt mortar of the CR mixtures from a mesoscopic perspective. The time–temperature sweep (TTS) test was conducted to obtain the rheological parameters of each corresponding emulsified residue and the permanent deformation performance of each CR mixture was measured by dynamic creep test. A principle component analysis (PCA) was used to compare the typical performance parameters of the CR mixtures and find the factors controlling the rutting resistance of CR mixtures. The results show that the high-temperature performance of the CR mixtures with a modified emulsified asphalt showed improvements relative to the nominal case. Including Marshall stability, several parameters from the rheological properties of binder (G*/sinδ, flow number) and mortar thickness (max, range proportion 0–10 mm) could significantly influence the high-temperature performance and rutting resistance of the CR mixtures.
Robust Stereo Visual-Inertial Odometry Using Nonlinear Optimization

The fusion of visual and inertial odometry has matured greatly due to the complementarity of the two sensors. However, the use of high-quality sensors and powerful processors in some applications is difficult due to size and cost limitations, and there are also many challenges in terms of robustness of the algorithm and computational efficiency. In this work, we present VIO-Stereo, a stereo visual-inertial odometry (VIO), which jointly combines the measurements of the stereo cameras and an inexpensive inertial measurement unit (IMU). We use nonlinear optimization to integrate visual measurements with IMU readings in VIO tightly. To decrease the cost of computation, we use the FAST feature detector to improve its efficiency and track features by the KLT sparse optical flow algorithm. We also incorporate accelerometer bias into the measurement model and optimize it together with other variables. Additionally, we perform circular matching between the previous and current stereo image pairs in order to remove outliers in the stereo matching and feature tracking steps, thus reducing the mismatch of feature points and improving the robustness and accuracy of the system. Finally, this work contributes to the experimental comparison of monocular visual-inertial odometry and stereo visual-inertial odometry by evaluating our method using the public EuRoC dataset. Experimental results demonstrate that our method exhibits competitive performance with the most advanced techniques.
Erectile Dysfunction: A Primer for in Office Management

Introduction: Optimizing erectile dysfunction (ED) remains a clinically significant endeavor as insufficient outcomes from oral, injectable and even surgical approaches to treatment remain less than ideal. In this report, we integrate evolving knowledge and provide an algorithmic approach for the clinician to fine-tune management. Methods: We performed a PubMed and Medline search of Erectile Dysfunction treatment optimization, enhanced patient efficacy for ED, and why men fail ED treatment. All relevant papers for the past two decades were reviewed. Results: Establishing the goals and objectives of the patient and partner while providing detailed instructions for treatment can minimize failures and create an environment that allows treatment optimization. A thorough work-up may identify reversible or contributing causes. We identified several areas where treatment of ED could be optimized. These include; management of associated medical conditions, lifestyle improvements, PDE5 inhibitor prescription strategies, management of hypogonadism and the initiation of intracavernosal injection therapy (ICI). Conclusions: In our view, once a man presents for help to the clinician, use of the simple strategies identified in this review to optimize the tolerability, safety and effectiveness of the selected treatment should result in enhanced patient and partner satisfaction, with improved outcomes.
Healthy or Unhealthy? The Cocktail of Health-Related Behavior Profiles in Spanish Adolescents

The aim of this study was to identify the prevalence and clustering of health-related behaviors in Spanish adolescents and to examine their association with sex, body mass index (BMI), different types of sedentary screen time, and adherence to 24-hour movement guidelines. A final sample of 173 students (M = 12.99 ± 0.51) participated in this study. Cluster analysis was conducted based on five health-related behaviors: PA and sedentary time derived from accelerometers, as well as healthy diet, sedentary screen time, and sleep duration derived from self-reported scales. Recommendations for 24-hour movement guidelines (i.e., physical activity (PA), screen time, and sleep duration) were analyzed both independently and combined. A total of 8.9% of the sample did not meet any of the guidelines, whereas 72.3%, 17.3%, and 1.7% of the sample met 1, 2, or all 3 guidelines, respectively. Six distinct profiles were identified, most of them showing the co-occurrence of healthy- and unhealthy-related behaviors. Given that most of the adolescents failed to meet the combination of PA, screen time, and sleep duration guidelines, these findings suggest the necessity to implement school-based interventions that target multiple health behaviors, especially because (un)healthy behaviors do not always cluster in the same direction.
Chemical Composition, Antioxidant and Cytotoxicity Activities of Leaves, Bark, Twigs and Oleo-Resin of Dipterocarpus alatus

Dipterocarpus alatus (Dipterocarpaceae) is a medicinal plant whose use is well known for the treatment of genito-urinary diseases. However, there is no report of its cytotoxic potential. In this study, the chemical composition, antioxidant and cytotoxic activities of extracts of the leaves, bark, twigs and oleo-resin from D. alatus are investigated. Cytotoxicity was measured by the neutral red (NR) assay against HCT116, SKLU1, SK-MEL2, SiHa and U937 cancer cell lines and antioxidant capacity was evaluated by DPPH, ABTS radical scavenging, and ferric reducing antioxidant power (FRAP) assays. The chemical composition was analyzed by gas chromatography–mass spectrometry (GC-MS). Leaf, bark and twig extracts exhibited stronger antioxidant activity than oleo-resin, with bark extract showing the highest antioxidant activity and the highest total phenolic content. All samples showed more cytotoxic activity against the U937 cell line than HCT116, SKLU1, SK-MEL2 and SiHa cells with oleo-resin being more cytotoxic than melphalan against U937 cells. Chemical composition analysis of oleo-resin by GC-MS showed that the major components were sesquiterpenes, namely α-gurjunene (30.31%), (-)-isoledene (13.69%), alloaromadendrene (3.28%), β-caryophyllene (3.14%), γ-gurjunene (3.14%) and spathulenol (1.11%). The cytotoxic activity of oleo-resin can be attributed to the sesquiterpene content, whereas the cytotoxic and antioxidant activities of leaf, bark and twig extracts correlated to total phenolic content.
N-Glycoproteomic Profiling Reveals Alteration In Extracellular Matrix Organization In Non-Type Bladder Carcinoma

Treatment of advanced and metastatic bladder carcinoma is often ineffective and displays variable clinical outcomes. Studying this aggressive molecular subtype of bladder carcinoma will lead to better understanding of the pathogenesis which may lead to the identification of new therapeutic strategies. The non-type bladder subtype is phenotypically mesenchymal and has mesenchymal features with a high metastatic ability. Post-translational addition of oligosaccharide residues is an important modification that influences cellular functions and contributes to disease pathology. Here, we report the comparative analysis of N-linked glycosylation across bladder cancer subtypes. To analyze the glycosite-containing peptides, we carried out LC-MS/MS-based quantitative proteomic and glycoproteomic profiling. We identified 1299 unique N-linked glycopeptides corresponding to 460 proteins. Additionally, we identified 118 unique N-linked glycopeptides corresponding to 84 proteins to be differentially glycosylated only in non-type subtypes as compared to luminal/basal subtypes. Most of the altered glycoproteins were also observed with changes in their global protein expression levels. However, alterations in 55 differentially expressed glycoproteins showed no significant change at the protein abundance level, representing that the glycosylation site occupancy was changed between the non-type subtype and luminal/basal subtypes. Importantly, the extracellular matrix organization pathway was dysregulated in the non-type subtype of bladder carcinoma. N-glycosylation modifications in the extracellular matrix organization proteins may be a contributing factor for the mesenchymal aggressive phenotype in non-type subtype. These aberrant protein glycosylation would provide additional avenues to employ glycan-based therapies and may lead to the identification of novel therapeutic targets.
Methods of multi-agent movement control and coordination of groups of mobile units in a real-time strategy games

This thesis proposes an approach to Reactive Control in Real-Time Strategy (RTS) computer games using Multi-Agent Potential Fields. The classic RTS title StarCraft: Brooodwar has been chosen as testing platform due to its status in the competitive Artificial Intelligence (AI) scene. The proposed AI controls its units by placing different types of potential fields in objects and places around the game world. This work is an attempt to improve previous methods done with Potential Field in RTS.
GAMMA SEMIGROUPS ON WEAK NEARNESS APPROXIMATION SPACES

In this paper, we consider the problem of how to define Γ-nearness semigroup theory which extends the notion of a nearness semigroup and roughness of Γ-semigroups ([6] and [11]) to include the algebraic structures of near sets and rough sets, respectively. Also, we introduce some properties of aproximations and these algebraic structures.
Gamification : State of the Art Definition and Utilization

This paper analyzes a definition of gamification as "the use of game design elements in non-game contexts". In this context, gamification can be set in relation to and differentiated from exisiting research. Due to the fact that this definition allows various game design elements, these are related to the self-determination theory. Consequently, there is a discussion about what gamified applications are able to offer and what problems they indicate.
Promoting Semantic Interoperability of Contextual Metadata for Learner Generated Digital Content

Mobile phones are becoming “sensor packed devices”. With this possibilities for acquiring context has been widen. As a result of this, new computing paradigms are emerging. Moreover, mobile phones enable anyone in their possession to be a potential creator of mobile media objects. All this is having impact in the way human activities are performed and has changed the “social mobile media” landscape. The emerging mobile media objects are usually created in an unanticipated way. The challenge in these settings is the interoperability and reusability of these emerging mobile media objects. Since there is no formal control over the creation of these mobile media objects, we consider that use of contextual metadata will be beneficial for addressing the issue of reusability. Inspired from our dimensional model of context we introduce a conceptual scheme for enhancing the reusability of mobile media objects. This scheme is based upon open standards technologies such as XML, XMLSchema, RDF and RDFSchema. To illustrate the usefulness of depicting emerging mobile media objects with contextual metadata, we introduce an experimental scenario in learning domain.
Zero Harm During Transition in Care From the Emergency Department to Medical/Surgical Units

Supplemental Digital Content is Available in the Text. Background: Health care–related errors are the third leading cause of death in the United States. When evidence-based processes are applied, harm related to health care errors can reach zero. Purpose: The purpose was to achieve zero preventable harm to patients during transitions in care from the emergency department (ED) to medical/surgical (Med/Surg) areas. Methods: A performance improvement process was used to drive the evidence-based design to eliminate harm in transitions from the ED to Med/Surg units. Once initial design was complete, small tests of change were deployed until zero harm was achieved. Results: Zero harm during transitions from the ED to Med/Surg areas was achieved. The use of formal performance improvement systems, tools, and evidence-based practices allows organizations to achieve and sustain zero harm during these transitions in care. Conclusion: This transitions project met multiple objectives. In addition, throughput efficiencies were realized.