Miracle-dz/UniFAR-FTUs huggingface dataset:
Speeds of Young E-Cyclists on Urban Streets and Related Risk Factors: An Observational Study in Israel

In Israel, a growing use of electric bicycles by youngsters has been noted, with an increase in related injuries. In this study, an observational survey was conducted on typical urban streets, aiming to characterize the riding speeds of young e-cyclists compared to regular cyclists and the associated risk factors in their behaviors. The survey covered 39 sites in eight cities, and included 1054 cyclists. The results showed that mean speeds of young e-cyclists were higher than those of regular cyclists at all types of sites, with a difference of 6–9 km/h. The mean speeds of e-bicycles were below 25 km/h, as prescribed by law, but the 85-percentile speeds were higher. E-cyclist speeds depend on the type of street, road layout and place of riding. More e-cyclists used the roadway compared to regular cyclists, however, on divided roads, more e-cyclists used sidewalks in spite of the law prohibition, thus endangering pedestrians. The majority of cyclists did not wear helmets. The unsafe behaviors of teenage e-cyclists increase the injury risk for themselves and for other road-users. Thus, separate bicycle infrastructure should be promoted in the cities. Road safety education and training of young e-cyclists with stronger enforcement of traffic regulations are also needed.
Systematic Analysis of the Clinical Relevance of Cell Division Cycle Associated Family in Endometrial Carcinoma

Background: Endometrial carcinoma (EC) is the most common cancer of female reproductive system, thus requiring for new effective biomarkers which could predict the onset of EC and worse prognosis. Cell Division Cycle Associated (CDCA) family plays indispensable roles in cell cycle process. However, no study has been focused on the role of CDCAs in EC. Our study aims to investigate the clinical relevance, potential biologic functions and molecular mechanisms of CDCAs in EC. Methods: GEPIA, cBioPortal, GeneMANIA, Networkanalyst, TCGA-UCEC cohort were utilized in this study. Results: NUF2 and CDCA2/3/4/5/7/8 were significantly highly expressed in EC compared with normal tissues. The patients with high NUF2 and CDCA2/3/4/5/8 expression tended to develop to advanced FIGO stages, poor differentiation and worse prognosis(in both OS and RFS analyses) than those with low expression. By contrast, elevated CDCA7 was significantly associated with better prognosis. CBX2 exerted no significant prognostic impact on EC patients. Distinct patterns of the genetic alterations of CDCAs were observed in various histological subtypes of EC. The biological functions of NUF2 and CDCA2/3/4/5/8 were mainly related with the activation of the following pathway: cell cycle, DNA replication, base excision repair, mismatch repair, nucleotide excision repair, cellular senescence and p53 signaling pathway. Conclusions: Our study provides new insight into the onset and progression of EC and proposes NUF2 and CDCA2/3/4/5/8 could act as oncogenes and have shown great diagnostic and prognostic promise in improving EC patient detection and survival prediction with accuracy.
Monitoring Negative Energy Balance in Transition Cows for Better Dairy Herd Results

Most transition dairy cows visit a state of negative energy balance (NEB) due to increased energy demands after parhrition coupled with lagging dry matter intake (Hayirli et a1., 2002). The ability to g partition available energy for milk production early in lactation (Bauman and Currie, 1980) has made the role of energy balance a key factor in the study of milk production, reproductive performance, and disease occurrence. The metabolites non-esterif,ted fatty acids (NEFA) and/or Bhydroxytutyrate (BHB) are common measures of NEB and/or ketosis in transition animals (Duffield eta1.,2009). Although some elevation of these metabolites is normal as these animals balance energy intake and energy demands, excessive elevation can indicate poor adaptation to NEB (Herdt, 2000). Identification of an objective level where NEFA andlor BHB are excessive and cause detrimental effects on health, reproduction and milk production, has been difficult due to individual animal variations, normal metabolite elevations during the transition period, and the multiple herdlevel factors that can affect the outcomes of interest.
Contribution of Nanotechnology and Nanomaterials to the Treatment of Diabetic Patients by Aid of Novel Inventions

Nanoscience and Nanotechnology are highly growing their significance in diabetic supplies and research nowadays. It is an area that included nanomaterials, nanosensors and nanostructures as well as nanoparticle projects and also their usage in human health research. Particularly, nanotechnology helps to the production of diabetic supplies, materials together with the development of novel glucose and insulin injection devices as well as their measurement sensors by the aid of nanomaterials. These materials mostly could be metal nanoparticles together with carbon nanostructures by nano dimension delivery mechanisms modalities which hold the potential to vividly recover the excellence of life of diabetic patients. Nanoscience and nanotechnology in diabetic research have facilitated and provided more truthful data for identifying diabetes mellitus. It is also worth mentioning that the nanotechnology could highly enhance the impact of drug delivery by addition of nanoscale materials and increase the glucose feeling, temporal response as well as glucose nursing. Furthermore, it is proposing novel nanoscale methods named closed-loop insulin delivery approaches which mechanically release insulin drug in reply to fluctuating blood glucose Review Article Najigivi et al.; AJOCS, 8(1): 29-40, 2020; Article no.AJOCS. 57899 30 heights. Besides, the mixture of nanotechnology by medication has shaped a novel field of nanomedicine which could enhance human health level. It is worthwhile to mention that some of the applications of nanotechnology for the treatment of diabetic patients can be the production of diabetic supplies by nanotechnology. One of the most important diabetic instruments that could highly relieve the life of patients these days could be nano diabetic shoes which will describe here. In this research, applications of nanoscience and nanotechnology in treating diabetic patients were discussed.
POWER FLOW ANALYSISOF SINGLE-PHASE THREE-WIRE PREMISES WIRING SYSTEM

Single-phase two-wire (12w) feeders or branch circuits are common in premises wiring system serving lighting and small-appliance loads. However, single-phase three-wire (13w)feeders and branch circuits have some advantages, such as:moderatingvoltage drop, reducing lineloss and cutting the amount of conductors. This paper presents a novel approach to solve the power flow problem of the 13w premises wiring system.The proposed approach is based on the loop frame of reference, rather than the traditional approach which is normally based on the bus frame of reference.Because the proposed approach is mainly on the basis of the foundation ofgraph theory, the feeders or branch circuitscan be represented in a more detailed manner. Furthermore, the performance equation or full-scale model of the premises wiring system can be builtin an easy way. Final, the proposed approach was verified through comparison of its results with the measurement data of field tests. The proposed approach and implementation technique are of value to engineers and techniciansf in the design and operation of premises wiring system for dwelling units or smart buildings and may be implemented in the energy management system (EMS).
Magnetic Sensor Array System: an Innovative Approach to Train Localization

In a railway environment, train localization is necessary to have a safe and efficient traffic within the railway network of tracks. This work presents a study regarding a magnetic sensor system, which is used for train localization. At present, train position is usually determined by computing the travelled distance from the last beacon, using a wheel-turn counter. So far, this localization system has been the best solution for environments where satellite localization is not available, as for example in tunnels. Train localization using magnetic sensors achieves performances similar to satellite localization. Besides, magnetic localization does not rely on additional infrastructure on the track-side and it is always available. During this work, a system based on multiple low-cost magnetic sensors has been designed, built and tested. The result is the magnetic sensor array system: an on-board train localization system with accuracy comparable to the satellite localization based systems. This work has a threefold objective. First, to test if accurate train localization is achievable with low-cost magnetic sensors. Second, to determine if the combined use of multiple magnetic sensors can improve the localization accuracy performances. Third, to determine if it is possible to recognize and exclude the magnetic field distortion caused by a neighboring train. A first experiment was conducted to answer the first two questions. According to the results, a single low cost sensor is not enough to achieve accurate localization, but the combined used of multiple low-cost sensor provides reliable information to train localization. When matching the last 30 meters of collected magnetic data, the single sensor provided the right train position on 80% of the time, while the multiple sensor system provided the correct position on 99% of the time on the single measurement. A second experiment investigated the decay of the magnetic field disturbance caused by a neighboring train on a standard train-to-train distance across two parallel tracks. According to the obtained results, the magnetic influence on the external side is reduced down to 20% with respect to the internal side, making it possible to detect and exclude the neighboring train disturbance.
A Comparative Study of the Malaysian Garden Concept (MGC) Criteria Application on the Public Parks

Today there are public parks that are named with the Malaysian Garden. Researchers need to determine whether the design of the public parks is following the MGC guidelines provided by the National Landscape Department. Public parks that use the name of the Malaysian Garden / "Taman Malaysia" will be an example of MGC gardens. The main objective of this study is to find out the level of use of MGC criteria in public parks that have used the Malaysian Garden as its name. In this paper, researchers have used qualitative methods, namely, observation and interview experts. The results of the study found that the application of MGC criteria is placed in the weak category. However, three main factors are the cause of non-compliance with the MGC criteria. Furthermore, this study has explained to us the criteria that underlie the design of the MGC.
Transmission dynamic of Tuberculosis in two dissimilar groups through pathogens: A SIRS model

Tuberculosis is a communicable disease which spreads in the human population through pathogens. Coughing by the infective individual generate large number of droplets. In this paper, a SIRS mathematical model is proposed to study the transmission of Tuberculosis by droplet infection in two dissimilar groups, considering the economic status of the individuals. The basic reproduction number R0 from the model has been derived for the study of disease dynamics. It has been shown that the disease free equilibrium point is stable if R0 < 1 and unstable if R0 > 1. It has been also shown that the unique endemic equilibrium point exists when R0 > 1. It may be concluded that if R0 < 1 then the disease will not spread and if R0 > 1 then the disease will be endemic in the population. We have also concluded from the analysis of the model that Tuberculosis can be controlled by reducing the rate at which an infective individual produces pathogens. The analytical results are supported by the relevant graphs.
Expression of heat shock protein 70-1 gene in bovine peripheral blood mononuclear cells

The present study has demonstrated the expression of HSP70-1 gene in bovine peripheral blood mononuclear cells (PBMCs). Blood samples were collected aseptically by jugular vein puncture in EDTA (1mg/ml) from six apparently healthy sahiwal cows (Bos Indicus). Peripheral blood mononuclear cells (PBMCs) were separated from the blood using HiSepTM Lymphocyte Separation Media (LSM). Total RNA was isolated from PBMCs using Trizol reagent. The purity and concentration of total RNA was checked using Nanodrop instrument whose further confirmation was made by using denaturing agarose gel (1.5%) electrophoresis. Isolated total RNA was reverse transcribed to cDNA that was used for amplification of HSP70-1 gene. Full length open reading frame (ORF) of HSP70-1 gene was amplified using specific primers pair. The presence of 1926 base pair band in denaturing agarose indicated the amplification of HSP70-1 gene. To conclude, our results demonstrate that HSP70-1 gene is expressed in bovine PBMCs.
ON SOME PRACTICAL ASPECTS OF CLICK THIOL-ENE REACTIONS FOR POLYMER MODIFICATION AND CONJUGATION WITH BIOMOLECULES

Thiol-ene reactions are among the most popular click reactions, being particularly appealing for functionalization of polymer materials and conjugation with proteins. However, although the formal definition of "click chemistry" can be very strict, one can easily arise some controversial issues related to the application of thiol-ene reactions in actual process conditions. In order to illustrate some of these issues, thiol-ene reactions were performed at conditions that simulate the conjugation of proteins with unsaturated polymers. It is shown that the presence of a heterogeneous reacting system can exert enormous impact on the performance of thiol-ene reactions, which has been largely overlooked in the literature. It is also shown that the performance of heterogeneous click reactions depends on the many constituents of the reacting system so that the design of click reactions requires detailed analysis of the desired reaction system and may not necessarily constitute a mechanistic route for immediate bioconjugation applications.
Power Quality Improvement of Wind Power Plants by Active Filters Embedded in STATCOMs

The application of active filtering in large offshore wind power plants is presented in this paper. Harmonic challenges from harmonic emissions and resonances are identified. Modern remedial harmonic mitigation methods such as active filtering are described. It is shown that wind power plant components such as high voltage alternating current export power cables and park transformers can introduce significant low-frequency resonances which can cause a significant harmonic distortion at the point of common coupling. It is demonstrated that active filtering in modern grid-side converters used in static synchronous compensators, which simultaneously provide voltage and reactive power control, is a matured, robust and feasible solution for wind power plants.
POLYPHASE SEQUENCES ANALYSIS WITH GOOD MERIT FACTOR AND CORRELATION PROPERTIES

Polyphase sequences such as Pn (n = 1, 2, 3, 4, x), Frank, Golomb, the Chu with large Merit factor and correlation properties are helpful in applications like RADAR, SONAR, channel estimation and communications. The Correlation function of a given sequence expressed by integrated sidelobe level (ISL). The ISL related metrics minimized by improving the performance parameters Merit Factor (MF) and Modified Merit Factor (MMF). In this paper, the merit factors are compared with all sequences for the usual case and considering the Weights (ones and zeros throughout the sequence length) from 10 to 10. The observation is made for four consecutive even, and odd square integer lengths say 16, 17, 18, and 19. The Px sequence exhibits the best merit factor among all Polyphase sequences. P2 sequence existed only for even square integer length when no weights applied. P1, Px, Frank sequences shows the good MMFs among all Polyphase sequences. For the possible lengths, the Elapsed time is more for MF than MMF except at four consecutive even and odd square integer lengths.
Evolutionary dynamics of organizations

The book presents the latest research and theory about evolutionary change in organizations. It brings together the work of organizational theorists who have challenged the orthodox adaptation views that prevailed until the beginning of the 1980s. It emphasizes multiple levels of change - distinguishing change at the intraorganizational level, the organizational level, the population level, and the community level. The book is organized in a way that gives order and coherence to what has been a diverse and multidisciplinary field. (The book had its inception at a conference held at the Stern School of Business, New York University, January 1992.)
A Global Test of Association between Non-Hodgkin Lymphoma and SNPs in Histone-pathway Genes

Identifying biological pathways affecting cancer susceptibility can provide insight into prevention. In tumour cells of non-Hodgkin lymphoma (NHL), histone-pathway genes are frequent targets of somatic mutation. We analyze data from a population-based case-control study to test whether NHL is associated with SNPs in histone-pathway genes. When individual SNP associations are minor, the standard approach of testing SNPs one-at-a-time and then correcting for multiple testing has low power. Our global testing approach avoids the multiple-testing penalty by modelling random SNP effects and testing variance. We show how an approximate score statistic may be derived by writing the likelihood as an expected conditional likelihood given latent genetic values for each individual and then applying a Taylor-series approximation. The resulting statistic is applied to the NHL data and its statistical significance is evaluated using a permutation-based procedure. Our results add to growing evidence that the histone pathway plays a role in NHL.
Rules of Origin and Market Power

We study how regional content requirements in Free Trade Areas (FTAs) affect market power and market structure in concentrated intermediate goods markets. We show that content requirements increase oligopolistic markups beyond the level that would obtain under an equivalent import tariff, and we document patterns in Canadian export data and US producer price data that align with the model’s predictions: producers of intermediate goods charge comparatively higher prices when the associated final goods producers are more constrained by FTA origin requirements and by Most Favoured Nation (MFN) tariffs for both intermediate and final non-FTA goods.
DNA polymerase α interacts with H3-H4 and facilitates the transfer of parental histones to lagging strands

DNA Pol α transfers parental histones to lagging strands. How parental histones, the carriers of epigenetic modifications, are deposited onto replicating DNA remains poorly understood. Here, we describe the eSPAN method (enrichment and sequencing of protein-associated nascent DNA) in mouse embryonic stem (ES) cells and use it to detect histone deposition onto replicating DNA strands with a relatively small number of cells. We show that DNA polymerase α (Pol α), which synthesizes short primers for DNA synthesis, binds histone H3-H4 preferentially. A Pol α mutant defective in histone binding in vitro impairs the transfer of parental H3-H4 to lagging strands in both yeast and mouse ES cells. Last, dysregulation of both coding genes and noncoding endogenous retroviruses is detected in mutant ES cells defective in parental histone transfer. Together, we report an efficient eSPAN method for analysis of DNA replication–linked processes in mouse ES cells and reveal the mechanism of Pol α in parental histone transfer.
3D printed patient-specific aortic root models with internal sensors for minimally invasive applications

3D printed patient-specific aortic root models with internal sensor arrays can augment the planning of medical procedures. Minimally invasive surgeries have numerous advantages, yet complications may arise from limited knowledge about the anatomical site targeted for the delivery of therapy. Transcatheter aortic valve replacement (TAVR) is a minimally invasive procedure for treating aortic stenosis. Here, we demonstrate multimaterial three-dimensional printing of patient-specific soft aortic root models with internally integrated electronic sensor arrays that can augment testing for TAVR preprocedural planning. We evaluated the efficacies of the models by comparing their geometric fidelities with postoperative data from patients, as well as their in vitro hemodynamic performances in cases with and without leaflet calcifications. Furthermore, we demonstrated that internal sensor arrays can facilitate the optimization of bioprosthetic valve selections and in vitro placements via mapping of the pressures applied on the critical regions of the aortic anatomies. These models may pave exciting avenues for mitigating the risks of postoperative complications and facilitating the development of next-generation medical devices.
Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target

Host AP2M1 protein is exploited by diverse pathogenic viruses via their YxxØ protein motif during viral replication cycle. Targeting a universal host protein exploited by most viruses would be a game-changing strategy that offers broad-spectrum solution and rapid pandemic control including the current COVID-19. Here, we found a common YxxØ-motif of multiple viruses that exploits host AP2M1 for intracellular trafficking. A library chemical, N-(p-amylcinnamoyl)anthranilic acid (ACA), was identified to interrupt AP2M1-virus interaction and exhibit potent antiviral efficacy against a number of viruses in vitro and in vivo, including the influenza A viruses (IAVs), Zika virus (ZIKV), human immunodeficiency virus, and coronaviruses including MERS-CoV and SARS-CoV-2. YxxØ mutation, AP2M1 depletion, or disruption by ACA causes incorrect localization of viral proteins, which is exemplified by the failure of nuclear import of IAV nucleoprotein and diminished endoplasmic reticulum localization of ZIKV-NS3 and enterovirus-A71-2C proteins, thereby suppressing viral replication. Our study reveals an evolutionarily conserved mechanism of protein-protein interaction between host and virus that can serve as a broad-spectrum antiviral target.
Rupture of blood clots: Mechanics and pathophysiology

We investigate the biomechanical and structural origins of blood clot rupture with implications for thrombotic embolization. Fibrin is the three-dimensional mechanical scaffold of protective blood clots that stop bleeding and pathological thrombi that obstruct blood vessels. Fibrin must be mechanically tough to withstand rupture, after which life-threatening pieces (thrombotic emboli) are carried downstream by blood flow. Despite multiple studies on fibrin viscoelasticity, mechanisms of fibrin rupture remain unknown. Here, we examined mechanically and structurally the strain-driven rupture of human blood plasma–derived fibrin clots where clotting was triggered with tissue factor. Toughness, i.e., resistance to rupture, quantified by the critical energy release rate (a measure of the propensity for clot embolization) of physiologically relevant fibrin gels was determined to be 7.6 ± 0.45 J/m2. Finite element (FE) simulations using fibrin material models that account for forced protein unfolding independently supported this measured toughness and showed that breaking of fibers ahead the crack at a critical stretch is the mechanism of rupture of blood clots, including thrombotic embolization.