Miracle-dz/UniFAR-FTUs huggingface dataset:
OTT_A_262909 10075..10085

*These authors contributed equally to this work Purpose: Programmed death ligand 1 (PD-L1) is widely used for predicting immune checkpoint inhibitors but has a limited effect on predicting clinical response. The aim of this study was to examine the prognostic value and PD-1 inhibitor therapeutic efficiency of SNX20 in lung adenocarcinoma. Methods: We evaluated the mRNA and protein expression levels of SNX20 and PDL1 and confirmed their predictive role in clinical response to anti-PD-1 therapy in 56 patients with advanced, refractory lung adenocarcinoma treated with PD-1 inhibitors. The expression of SNX family in different cancer types and the relationship between SNX20 and immune cells were evaluated in TCGA. The protein expression levels of SNX20, PD-L1 in 56 lung adenocarcinoma tissues were evaluated by immunohistochemistry. Results: SNX20 mRNA expression has the strongest relationship with CD8a of the sorting nexin (SNX) family in lung adenocarcinoma and is strongly correlated with immune infiltration levels in 30 cancer types, especially in lung adenocarcinoma. A positive correlation between SNX20 and PD-L1 was found based on immunohistochemical data (Pearson’s r=0.3731 and p=0.0466). SNX20 and PD-L1 were also observed to have a significant positive correlation at the mRNA level. According to the receiver operating characteristic (ROC) curve, the best expression differentiation score of SNX20 and PD-L1 between responder versus non-responders in patients with lung adenocarcinoma using PD-1 inhibitors is 5. In univariate logistic regression analysis, both SNX20 (odds ratio [OR]=3.778, p=0.019) and PD-L1 (OR=5.727, p=0.004) expression levels are significant predictors of clinical response in the PD-1 inhibitor responder group, and SNX20 (OR=3.575, p=0.038) and PD-L1 (OR=5.484, p=0.007) are also predictors of the response to PD-1 inhibitors in the multivariate analysis. High SNX20/high PD-L1 expression group had longer overall survival than patients with high SNX20/low PD-L1 expression group or low SNX20/high PD-L1 expression group (p=0.013) and patients with low SNX20/low PD-L1 expression group (p=0.01). Conclusion: SNX20 expression can be a promising predictor for therapeutic decisionmaking and treatment response assessment regarding PD-1 inhibitors, and special attention is required for the subgroup of patients with lung adenocarcinoma whose tumors express both high SNX20 and PD-L1.
A Comprehensive Review: Energy Storage System for Hybrid System Including Wind Energy Generation System and Solar Energy Generation System for Utility Grid

Small grid industry has tremendous growth in the present market. This paper presents a comprehensive review of hybrid energy generation system with energy storage system. The hybrid system is the combination of wind energy conversion system and photo voltaic energy generation system with energy storage system. This system is grid connected so as to feed the energy in the grid and take the energy from the grid. Since this power is very highly variable when it is generated by the wind, solar etc. Consequently, Renewable energy has limited contribution in the power generation and this type of energy generation is difficult to control. So this problem is solved by integration of this hybrid energy system with Energy Storage System. This paper presents the up to date Technical review for Energy generation System with the integration of energy storage system. The aim of this paper is to provide a broad prospective on the status of hybrid energy generation with Energy Storage System and grid interfacing technology to Review Article Sharma and Gidwani; CJAST, 21(6): 1-13, 2017; Article no.CJAST. 34383 2 researcher & application engineers dealing with advantages, disadvantage and main application when it is connected to the power system. A more than hundred research articles on this subject is allow appended for a quick overview & reference.
The Influence of Kades’s Leadership Style Toward the Land and Building Tax (L and B Tax) Payment According to Equity Theory Perspective Versus Maslow Theory in Mataraman Javanese Society

The research aims to prove empirically the influence of Kades/kades’s leadership style to the L and B Tax payment obedience to the Mataraman Javanese society distinguished by its characteristic in being loyal to the leader. This research approaches quantitatively by using the primary data in the form of questionnaire directly spread to the respondents in 15 districts of Madiun. The result of the research shows that there are the influence between the kades’s leadership style assessment and the the L and B tax payment obedience. Based on the alternative test result, democratic and autocratic leadership styles have big influences in the obedience of L and B tax payment, meanwhile the participatory and delegative leadership styles do not. It confirms the Equity Theory where individual will always assess the received input and output equity. On the other hand, in accordance of Maslow’s Theory, the society which is on the physiological need stage tends to accept the autocratic leadership style since they remain to have no sufficient motivation to fulfill the social needs.
Carbonic Anhydrase and Its Influence on Carbon Isotope Discrimination during C4 Photosynthesis. Insights from Antisense RNA in Flaveria bidentis

In C4 plants, carbonic anhydrase (CA) facilitates both the chemical and isotopic equilibration of atmospheric CO2 and bicarbonate (HCO3 ) in the mesophyll cytoplasm. The CA-catalyzed reaction is essential for C4 photosynthesis, and the model of carbon isotope discrimination (DC) in C4 plants predicts that changes in CA activity will influence D C. However, experimentally, the influence of CA on DC has not been demonstrated in C4 plants. Here, we compared measurements of D C during C4 photosynthesis in Flaveria bidentis wild-type plants with F. bidentis plants with reduced levels of CA due to the expression of antisense constructs targeted to a putative mesophyll cytosolic CA. Plants with reduced CA activity had greater DC, which was also evident in the leaf dry matter carbon isotope composition (dC). Contrary to the isotope measurements, photosynthetic rates were not affected until CA activity was less than 20% of wild type. Measurements of DC, dC of leaf dry matter, and rates of net CO2 assimilation were all dramatically altered when CA activity was less than 5% of wild type. CA activity in wild-type F. bidentis is sufficient to maintain net CO2 assimilation; however, reducing leaf CA activity has a relatively large influence on DC, often without changes in net CO2 assimilation. Our data indicate that the extent of CA activity in C4 leaves needs to be taken into account when using DC and/or dC to model the response of C4 photosynthesis to changing environmental conditions.
An Empirical Study of the Number of Template Effects on the Efficiency of the Prototype of an Automated Logo Inspection Machine

A Product packages have logos printed on them. If these logos were defected, manufacturers may lose customers’ reputation. In addition, the automation increasingly plays an important role in manufacturing process since it can replace human workforce and decrease human errors. Therefore, a prototype of an automated logo inspection machine using pyramidal matching technique was designed and constructed for demonstration and test the efficiency of the proposed logo inspection machine. The original prototype utilized only one image of the package as a template, the experimental results show that the demonstrated machine can distinguish between the complete logos on packages and the defective ones even though the position of the packages were tilted up to ±90 degrees. However, if the package positions were 90 or -90 degrees, the accuracy of the template matching was decreased. Therefore, increasing the number of templates used in the pattern matching algorithm could improve the efficiency of the proposed logo inspection machine by utilizing four templates align in 0, +90, -90, and 180 degrees instead of only 0 degree position. Received by 12 August 2019 Revised by 15 December 2019 Accepted by 29 December 2019
Preparing for a Robot Future? Social Professions, Social Robotics and the Challenges Ahead

There have been significant developments in social robotics in the care sector: in particular, in the fields of elder care and in the care and education of children and young people, especially those with specific disabling conditions such as autism. Within the context of an increased interest in the social and ethical impact of automation and robotics, this paper, based on an overview of relevant literature, addresses some pertinent issues in the field of social robotics, social care and the social professions. It opens by pointing to the increasing application of information technologies in the care field, in areas such as Assistive Technology (AT) and Assistive Learning Technology (ALT). It defines social robotics and provides examples of relevant initiatives, prototypes and products in the care field, including and up to ‘third generation’ social robots. It outlines some of the challenges, in terms of ethics, human-robot relationships, acceptance and user-centred design, social impacts and issues of autonomy and control, and points to concerns about the professional identity of care providers. It identifies the need to respond in terms of educational/CPD supports and regulatory standards, for example in relation to the Irish regulators QQI and Coru. Finally, it suggests some pedagogical approaches to these issues that may be of assistance to educators, CPD practitioners and students within the social professions.
Forecasting Of Optimal Raw Material Supplies For Paving Block Making In UD. Karya Jaya

UD. Karya Jaya is one of the manufacturing companies engaged in the production of paving blocks, located in Keude Bungkah Village, Muara Batu, North Aceh. In the implementation of the production system, the company has been using machines and equipment that has been adapted to technological developments. In the sense, the machine used is a machine designed by the company, which has the level and effectiveness of production 99% has a perfect success for its products. In producing paving blocks, the raw materials used are cement, sand, gravel and paint additives. Such raw materials shall always be available for the smoothness of production. Available means according to production needs. Based on the above, it is necessary to calculate the inventory forecasting to avoid the accumulation of raw materials. The results showed that the forecasting method used to predict the demand of raw materials in the month of August 2017-July 2018 is Cement raw material is linear method, Sand raw materials is a quadratic method, raw materials of gravel and paints are linear methods. With the result of the forecast that is the amount of raw material demand for the period of August 2017-July 2018 average per month is the cement is 1098 sacks, Sand is 20 trucks, the gravel is 8 trucks and the paint is 105 sacks. Keywords— Production; Forecasting; Raw Materials.
Computational observations of the tip loss mechanism experienced by horizontal axis rotors

Blade resolved computations of two different horizontal axis rotors are carried out to investigate the tip loss mechanism experienced by horizontal axis rotors. The tip loss mechanism speciﬁcally refers to the effect of the vorticity that is shed from the outboard blade sections, which results in the blade loading dropping off as the tip is approached. In this paper, the shed vorticity is shown to induce a downwash at the rotor plane and spanwise ﬂow accelerations along the blade surfaces. While the downwash reduces the angle of attack of the approach ﬂow, the spanwise ﬂow accelerations lead to additional momentum transport along the blade. This spanwise momentum transport reduces the magnitude and changes the distribution of the static pressure developed on the pressure and suction surfaces of the outboard blade sections. As a result of this modiﬁcation, the torque producing force drops off faster than the thrust producing force as the tip is approached, resulting in a rotation of the net force vector towards the streamwise direction. This anisotropy must be accounted for by tip ﬂow corrections if the loading on the outboard blade sections is to be computed with sufﬁcient accuracy. In addition, it is also shown that changes in the static pressure distribution cannot be accurately approximated by only modifying the angle of attack of the approach ﬂow, as this would lead to blade loading changes which are inconsistent with the observed behaviour of the lift and drag coefﬁcients on the outboard blade sections. Copyright c (cid:13) 2017 John Wiley & Sons, Ltd.
S0003055420000076 596..602

Whyhavedecades of high and rising inequality in theUnited States not increased public support for redistribution? An established theory in political science holds that Americans’ distrust of government decreases their support for redistribution, but empirical support draws primarily on regression analyses of national surveys. I discuss the untestable assumptions required for identificationwith regression modeling and propose an alternative design that uses randomized experiments about political corruption to identify the effect of trust in government on support for redistribution under weaker assumptions. I apply this to three survey experiments and estimate the effects that large, experimentally induced increases in political trust have on support for redistribution. Contrary to theoretical predictions, estimated effects are substantively negligible, statistically indistinguishable from zero, and comparable to estimates from two placebo experiments. I discuss implications for theory building about causes of support for redistribution in an era of rising inequality and eroding confidence in government.
Pax regulation in eye development

The primordia, which give rise to the complex architecture of the mammalian eye, are regionalized and specified by autonomous as well as inductive cues (Saha et al., 1992). After the early inductive events, distinct processes are involved in the formation of the eye. During a morphogenetic phase, invagination of the ventral part of the optic vesicle occurs. The ectodermally derived lens is encircled by the invaginated tissue at the most distal part of the optic cup. Subsequently, this process results in the formation of the optic globe, consisting of outer pigmented retina, neural retina and the lens (Saha et al., 1992). Ventrally, the eye and a part of the optic stalk remain transiently open, marked by the optic fissure. The closure of the optic fissure marks the end of the morphogenetic period (reviewed in Oliver and Gruss, 1997). The early and dynamic expression of Pax2and Pax6during eye formation suggests a potential role for these genes in eye regionalization (Nornes et al., 1990; Torres et al., 1996; Walther and Gruss, 1991). Pax6 is expressed in the optic primordium and later in all cells of the prospective retina, pigmented epithelium and lens epithelium (Walther and Gruss, 1991; Grindley et al., 1995). Mutations in Pax6result in severe eye defects in mice (small eye) and humans (aniridia syndrome; Hill et al., 1991; Glaser et al., 1994; Hogan et al., 1988; Grindley et al., 1995). Pax6deficient mice completely lack eyes (Hill et al., 1991). In contrast to Pax6, Pax2 is expressed in the ventral half of the optic vesicle during early eye morphogenesis (Nornes et al., 1990; Torres et al., 1996). Shortly after the invagination of the optic cup it becomes confined to the optic stalk (Nornes et al., 1990; Torres et al., 1996). However, its expression persists throughout the whole morphogenetic phase at the lips of the optic fissure and extends into the optic stalk up to the brain (Nornes et al., 1990; Torres et al., 1996; Macdonald et al., 1995; Macdonald and Wilson, 1996). During this period, the developing optic cup/optic stalk border is marked by overlapping Pax2and Pax6expression domains (Nornes et al., 1990; Walther and Gruss, 1991). Mutations in the human PAX2 gene result in optic nerve colobomas (Sanyanusin et al., 1995). In mice deficient for Pax2, the optic nerves project only ipsilaterally to the superior colliculus (Torres et al., 1996). In addition, the Pax6-expressing pigmented epithelium of the retina has been shown to expand in the Pax2mutant embryos, invading the optic cup/optic stalk boundary (Torres et al., 1996). In the present study, we investigate the molecular mechanism by which the expression patterns of these transcription factors in the visual system become defined to form a sharp boundary between regions acquiring different fates. We tested a possible reciprocal transcriptional repression 4325 Development 127, 4325-4334 (2000) Printed in Great Britain © The Company of Biologists Limited DEV2580
Association of Complement C3 Inhibitor Pegcetacoplan with Photoreceptor Degeneration Beyond Areas of Geographic Atrophy

Preservation of photoreceptors beyond areas of retinal pigment epithelium atrophy is a critical treatment goal in eyes with geographic atrophy (GA) to prevent vision loss. Thus, we assessed the association of treatment with the complement C3 inhibitor pegcetacoplan with optical coherence tomography (OCT)-based photoreceptor laminae thicknesses in this post hoc analysis of the FILLY trial (NCT02503332). Retinal layers in OCT were segmented using a deep-learning-based pipeline and extracted along evenly spaced contour-lines surrounding areas of GA. The primary outcome measure was change from baseline in (standardized) outer nuclear layer (ONL) thickness at the 5.16 degree contour-line at month 12. Participants treated with pegcetacoplan monthly had a thicker ONL along the 5.16 degree contour-line compared to the pooled sham arm (mean difference [95% CI] +0.29 z-score units [0.16, 0.42],P<.001). The same was evident for eyes treated with pegcetacoplan every other month (+0.26 z-score units [0.13, 0.4],P<.001). Additionally, eyes treated with pegcetacoplan exhibited a thicker photoreceptor inner segment layer along the 5.16 degree contour-line at month 12. These findings suggest that pegcetacoplan could slow GA progression and lead to a lesser thinning of photoreceptor layers beyond the GA boundary. Future trials in earlier disease stages, i.e., intermediate AMD, aiming to slow photoreceptor degeneration warrant consideration.
A terrain treadmill to study animal locomotion through large obstacles

A challenge to understanding locomotion in complex 3-D terrain with large obstacles is to create tools for controlled, systematic experiments. Recent terrain arenas allow observations at small spatiotemporal scales (∼10 body length or cycles). Here, we create a terrain treadmill to enable high-resolution observation of animal locomotion through large obstacles over large spatiotemporal scales. An animal moves through modular obstacles on an inner sphere, while a rigidly-attached, concentric, transparent outer sphere rotates with the opposite velocity via closed-loop feedback to keep the animal atop. During sustained locomotion, a discoid cockroach moved through pillar obstacles for up to 25 minutes (2500 cycles) over 67 m (1500 body lengths). Over 12 trials totaling∼1 hour, the animal was maintained within a radius of 1 body length (4.5 cm) on top of the sphere 90% of the time. The high-resolution observation enables study of diverse locomotor behaviors and quantification of animal-obstacle interaction.
Possible Sarcopenia and Its Association with Nutritional Status, Dietary Intakes, Physical Activity and Health-Related Quality of Life among Older Stroke Survivors

Background Screening for sarcopenia in the stroke population is an emerging concept in research and clinical practice. Therefore, this cross-sectional study aimed to assess the prevalence of possible sarcopenia and its associated factors among older stroke survivors who visited the neurology and rehabilitation departments of three public hospitals in Malaysia. Methods We acquired data on sociodemographic characteristics, clinical profiles, malnutrition risk, dietary intake, physical activity level, and health-related quality of life. Possible sarcopenia was diagnosed in individuals with decreased calf circumference and low handgrip strength, as proposed by the Asia Working Group for Sarcopenia (2019). Finally, we performed descriptive analysis and binary logistic regression. Results Among 196 older adults with stroke (mean± standard deviation of age: 67.60 ± 5.70 years), 42.3% had possible sarcopenia, with a higher prevalence in the more advanced age group (≥70 years). In univariable analysis, possible sarcopenia was significantly associated with anthropometric indices, malnutrition risk, nutrient intake, physical activity level, and health-related quality of life. In multivariable analysis, body mass index (adjusted odds ratio [AOR]=0.57; 95% confidence interval [CI], 0.43–0.75) was the only factor associated with possible sarcopenia among individuals aged ≥70 years. Recurrent stroke (AOR=3.48; 95% CI, 1.02–11.92), body mass index (AOR=0.64; 95% CI, 0.54–0.76), and EQ-5D index (AOR=0.15; 95% CI, 0.03–0.78) were significantly associated with possible sarcopenia in the 60–69-year age group. Conclusion The prevalence of possible sarcopenia among community-dwelling older stroke survivors was high. Therefore, we recommend routine screening for possible sarcopenia to ensure early nutritional and exercise intervention.
Proposta de aplicação do ciclo PDCA para melhoria contínua do sistema de confinamento bovino: um estudo de caso

This work aims to describe a project proposal using the PDCA cycle as a driving force for the process of continuous improvement in a bovine confinement system. This is an applied research, operationalized by the case study method, using a rural property in the south of the State of Rio Grande do Sul as unit of analysis. We applied PDCA cycle as an intervention instrument. The main results of the research were the diagnosis of the problems of the confinement process, through the Ishikawa diagram, as well as suggestions to promote the improvement of the quality of the confinement process, taking as reference the indicators from the application of the 5W2H and SEFTI techniques.
Can occipital lobe bending, Gibraltar sign of superior sagittal sinus groove and jugular foramen dimensions predict transverse sinus dominance?

Background Asymmetry between the transverse sinuses (TS) is quite common. We sought to test the possible hypothesis that certain anatomical features – namely, occipital lobe bending, Gibraltar sign of superior sagittal sinus groove (SSS) and jugular foramen (JF) dimensions – can predict dominance of the transverse sinuses on routine axial T1- and T2-weighted images. Materials and methods One hundred consecutively acquired combined MRI-MRV studies of brain were reviewed. On non-contrast axial T1WI, each reviewer assessed the occipital lobe bending, and Gibraltar sign of SSS groove; on axial T2-weighted images, JF dimensions were measured. TS cross-sectional area was measured on non-contrast sagittal 2-dimensional phase contrast MRV images and served as the reference standard. Results Of the 51 subjects with right-dominant TS, 37 had occipital bending to the right side and 35 showed sloping of the Gibraltar sign to right side. Of the 18 subjects with left dominant TS, 10 had occipital bending to left side and 13 showed left-sided sloping of the Gibraltar sign. Of the 31 subjects with co-dominant TS, 15 had no occipital bending and 20 showed no sloping of the Gibraltar sign. Mean right and left JF dimensions were higher in the right and left dominant TS respectively with no significant differences in patients with co-dominant sinus (p < 0.02). Conclusion Right occipital bending had a good association with right TS dominance. The other two parameters- Gibraltar sign of superior sagittal sinus groove and jugular foramen dimensions – did not have a very good association with respect to TS dominance.