Miracle-dz/UniFAR-FTUs huggingface dataset:
Reconsidering Novel Technology Introduction Strategies: Impacts of Technology, Design, and Market Attributes on 118 Japanese Product Development Projects

: This study reconsiders product development strategies for the introduction of advanced technologies into new products. The exploitation and exploration of novel technologies in product development are critical issues for manufacturing firms. Yet, thus far, the concept and determinants of novel technology introduction strategies have often been blurred. Drawing on 118 successful Japanese assembly product development projects, this study attempts to elaborate the concept of novel technology introduction strategies and explores the effects of other determinants on the strategies. The study finds two alternative novel technology introduction strategies: technology integration and separated technology development. The results demonstrate that successful projects exploit either of these strategies according to knowledge regarding product designs and/or customer/market needs as well as technological uncertainty. The findings of this study should help firms contrive to develop novel technology introduction strategies at the project level, as well as multiproject strategies at the business level.
Search for a RPV resonance in the μ τ final state at CMS

This bachelorthesis is about the search for a resonant, lepton number violating decay of a tau sneutrino into the μτ final state. Only tau leptons which decay hadronically are taken into account. This is done using 2015 CMS data with a center-of-mass energy of 13 TeV and an integrated luminosity of 2.7 fb−1. Different types of tau discriminators are studied and various kinematic cuts are applied to optimize the signal to background ratio. As there is no sign for non standard model processes in the final invariant μτ -mass distribution, a limit on the tau sneutrino mass is calculated.
Journal of Dental Sleep Medicine | Volume 3, Number 3 | July 10, 2016

s of the 25th Anniversary Meeting of the American Academy of Dental Sleep Medicine: Denver, CO, June 9–11, 2016 Editor-in-Chief Leslie Dort, DDS Deputy Editor Olivier Vanderveken, MD, PhD Associate Editors Fernanda Almeida, DDS, PhD Gilles Lavigne, DMD, PhD Rose Sheats, DMD Executive Director Jerome A. Barrett Managing Editor Andrew Miller Journal of Dental Sleep Medicine (JDSM) (Online 2333-9756; Website: www.jdsm.org) is published online quarterly on the 10th of January, April, July and October by the American Academy of Dental Sleep Medicine, 2510 North Frontage Road, Darien, IL 60561-1511, phone (630) 737-9705 and
Effects of water stress on water use ef fi ciency of irrigated and rainfed wheat in the Loess Plateau , China

• The ratio of irrigated to rainfed winter wheat in the Loess Plateau was examined. • Maximum light use efficiency and harvest index of winter wheat were estimated. • Higher yield and actual evapotranspiration were found in irrigated winter wheat. • Water use efficiency decreased more rapidly in rainfed wheat under water stress. ⁎ Corresponding author at: State Key Laboratory of Soil E-mail address: qiang.yu@uts.edu. au (Q. Yu). https://doi.org/10.1016/j.scitotenv. 2018.06. 028 0048-9697/© 2018 Elsevier B.V. All rights reserved. a b s t r a c t a r t i c l e i n f o
Effect of molybdenum and tungsten on synthesis and composition of formate dehydrogenase in Methanobacterium formicicum

The influence of sodium molybdate and sodium tungstate on formate dehydrogenase activity was studied in H2-CO2-grown cultures of Methanobacterium formicicum. Depletion of molybdate from the growth medium resulted in a 75-fold decrease of intracellular molybdenum and a 35-fold decrease in enzyme activity; however, growth rate and cell yields were not influenced. By using an indirect enzyme-linked immunoassay, the amount of formate dehydrogenase approximated 3% of the total protein in cells grown in the presence of molybdate. Molybdenum-starved cells contained approximately 15-fold less formate dehydrogenase protein; Western blot (immunoblot) analysis revealed that both subunits of the enzyme were synthesized. Molybdenum starvation resulted in an increase in the amount of mRNA that hybridized to fdh-specific DNA. The results indicated an inverse relationship between the amount of transcript and the amount of formate dehydrogenase protein detected in response to molybdenum starvation. The addition of 1 mM tungstate to molybdate-containing media resulted in nearly complete loss of enzyme activity and decreased the intracellular concentration of molybdenum 10-fold. Cells grown in the presence of tungstate synthesized high amounts of inactive formate dehydrogenase and contained mRNA that hybridized to fdh-specific DNA in amounts similar to that in cells grown with sufficient molybdate. Inactive formate dehydrogenase, purified from cells grown in the presence of tungstate, had the same subunit composition and contained amounts of molybdopterin cofactor, albeit metal-free, comparable to those in the active enzyme.
Generalized Multiple-Model Adaptive Estimation using an Autocorrelation Approach

In this paper a generalized multiple-model adaptive estimator (GMMAE) is presented that can be used to estimate unknown model and/or filter parameters, such as the noise statistics in filter designs. The main goal of this work is to provide an increased convergence rate for the estimated model parameters over the traditional multiple-model adaptive estimator (MMAE). Parameter elements generated from a quasi-random sequence are used to drive multiple parallel filters for state estimation. The current approach focuses on estimating the process noise covariance by sequentially updating weights associated with the quasi-random elements through the calculation of the likelihood function of the measurement-minus-estimate residuals, which also incorporates correlations between various measurement times. For linear Gaussian measurement processes the likelihood function is easily determined. A proof is provided that shows the convergence properties of the generalized approach versus the standard MMAE. Simulation results, involving a two-dimensional target tracking problem and a single-axis attitude problem, indicate that the new approach provides better convergence properties over a traditional multiple-model approach.
Analysis of Entrepreneurship : How does Culture Influence Risk-Taking in SMEs in the Sekondi-Takoradi Metropolis , Ghana ?

This paper empirically examines the influence of culture on risk-taking, which is a key dimension of entrepreneurial orientation. Data from 354 self-administered questionnaires were utilized. Hofstede’s (1980) four cultural dimensions were adopted in stating the four hypotheses developed for this study. The data were analysed using descriptive statistic, Person’s Product Moment Correlation Coefficients and Multiple Linear Regression Analysis. The findings of this study indicate that power distant and masculinity had a significant positive relationship with risk taking. But, uncertainty avoidance and individualism recorded a non-significant positive relationship with risk taking. Hence, this study recommended that SMEs owner/manager must encourage inputs and suggestions from their employees and also seek for business advice from appropriate individuals and institutions instead of relying solely on their judgment.
Fast Image Stabilization and Mosaicking

We present two fast implementations of electronic image stabilization and mosaicking systems. The rst one is based on a 2D similarity model and is targeted to process PREDATOR video data. The second system uses a 3D model and compensates for 3D rotation. Both systems have been implemented on parallel pipeline imageprocessing hardware (a Datacube MaxVideo 200) connected to a Themis 10MP. Both algorithms use a featurebased multi-resolution technique which tracks a small set of features to estimate the motion of the camera. The extended Kalman lter framework is employed by the 3D de-rotation system. The inter-frame motion estimates relative to a reference frame are used to warp the current frame in order to achieve stabilization. The estimates are also used to construct mosaics by aligning the frames. A fast mosaicking implementation is presented for the 2D system. Experimental results demonstrate the robustness of both systems at frame rates above 10 frames/second.
Linking BIM and GIS Models in Infrastructure by Example of IFC and CityGML

This paper demonstrates how linked data can be used to provide a semantically rich connection between the domains of building information modeling (BIM) and geographic information systems (GIS). Expertise from both domains is necessary for the planning of infrastructure projects such as roads, tunnels, bridges, and railways, as these projects usually require the consideration of widely diverging scales. As BIM and GIS rely on different types of data modeling standards, a conversion between the data models will inevitably result in data loss. To overcome this problem, we propose to utilize the concept of Linked Data which allows the original data to coexist and provide coherence by establishing references between the corresponding entities of both standards. The approach is illustrated using exemplary models of shield tunnels in both, the IFC and the CityGML format.
Malware variant detection

Malware programs (e.g., viruses, worms, Trojans, etc.) are a worldwide epidemic. Studies and statistics show that the impact of malware is getting worse. Malware detectors are the primary tools in the defence against malware. Most commercial anti-malware scanners maintain a database of malware patterns and heuristic signatures for detecting malicious programs within a computer system. Malware writers use semantic-preserving code transformation (obfuscation) techniques to produce new stealth variants of their malware programs. Malware variants are hard to detect with today's detection technologies as these tools rely mostly on syntactic properties and ignore the semantics of malicious executable programs. A robust malware detection technique is required to handle this emerging security threat. In this thesis, we propose a new methodology that overcomes the drawback of existing malware detection methods by analysing the semantics of known malicious code. The methodology consists of three major analysis techniques: the development of a semantic signature, slicing analysis and test data generation analysis. The core element in this approach is to specify an approximation for malware code semantics and to produce signatures for identifying, possibly obfuscated but semantically equivalent, variants of a sample of malware. A semantic signature consists of a program test input and semantic traces of a known malware code. The key challenge in developing our semantics-based approach to malware variant detection is to achieve a balance between improving the detection rate (i.e. matching semantic traces) and performance, with or without the e ects of obfuscation on malware variants. We develop slicing analysis to improve the construction of semantic signatures. We back our trace-slicing method with a theoretical result that shows the notion of correctness of the slicer. A proof-of-concept implementation of our malware detector demonstrates that the semantics-based analysis approach could improve current detection tools and make the task more di cult for malware authors. Another important part of this thesis is exploring program semantics for the selection of a suitable part of the semantic signature, for which we provide two new theoretical results. In particular, this dissertation includes a test data generation method that works for binary executables and the notion of correctness of the method.
Oxidative stress-induced Gadd45α inhibits trophoblast invasion and increases sFlt1/sEng secretions via p38 MAPK involving in the pathology of pre-eclampsia

Abstract Background: Pre-eclampsia (PE) is one of the most common pregnancy-related complications. We have previously reported that growth arrest and DNA damage-inducible 45 alpha (Gadd45α) is over-expressed in trophoblasts in pre-eclamptic placentas, with an excessive activation of p38 mitogen-activated protein kinase (MAPK) and increased levels of soluble Fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEng) in maternal sera. Now we further investigate how Gadd45α regulates trophoblast functions and anti-angiogenesis factors secretions during placental development in patients with PE. Methods: Human placental villous explants were used to verify the effects of Gadd45α and p38 MAPK in placentation. Then HRT8/SVneo cells exposed to hypoxia/reoxygenation (H/R) were employed as an oxidative stress model to investigate the effects of Gadd45α on invasion and sFlt-1/sEng secretions. Through silencing Gadd45α with lentiviral vector-based short-hairpin RNA and inhibiting p38 MAPK with SB203580, we demonstrated that Gadd45α and its downstream p38 protein played roles in the pathology of pre-eclampsia. Results: Gadd45α was found to have increased expression in H/R-treated villous explants and HTR8/SVneo cells. Gadd45α knockdown or p38 blockage could promote trophoblast outgrowth and migration in H/R-exposed villous explants, and enhance the potentials of trophoblast migration/invasion and network formation in H/R-exposed HTR8/SVneo cells. These functional changes might be related to the increased activities of MMP2/9. Meanwhile, Gadd45α knockdown or p38 inhibition also decreases sFlt-1/sEng secretions via suppressing oxidative stress. Conclusions: Oxidative stress-induced overexpression of Gadd45α might influence the activity of MMPs through activation of p38 MAPK signaling to affect the invasion of trophoblast cells, and increase the secretions of sFlt-1/sEng, which then participate in the pathogenesis of pre-eclampsia.
12 A . 6 RADAR CLIMATOLOGY OF HONG KONG AND ITS APPLICATION TO LANDFALLING TROPICAL CYCLONE RAINFALL ESTIMATION

Radar climatology has been studied at many places over the world (Kuo & Orville 1973; James et al. 2004; Overeem et al. 2009; Chang et al. 2009; Weckwerth et al. 2011) for various purposes. In Hong Kong, the first radar climatological study was performed by Cheng and Kwong (1973), who analyzed the observations from a Plessey Type 43S Radar (10 cm wavelength) to study the diurnal, daily and monthly variations of radar echo coverage in Hong Kong during the period 1967-1969. One of the common themes in studying radar climatology is the effect of orography on precipitation. Recently, there are also case studies (Yu & Cheng 2008; Smith et al. 2009) using radar observations to investigate the orographic enhancement of precipitation due to typhoon or hurricane.
Proposal P 1044 – Plain English Allergen Labelling Safety Risk assessment Executive summary

FSANZ is preparing a proposal to consider potential changes to the Australia New Zealand Food Standards Code (the Code) that introduce requirements to use plain English allergen labelling (PEAL). As part of this proposal, consideration has been given to the clinical significance of mollusc allergy in Australia and New Zealand, which tree nuts are important in food allergy, and whether all cereals that contain gluten are also of concern for food allergy.
Simulating Gravity , Potential , and Sea Level Change with Topologically Realistic Earthquake Fault System Models

Following the success of the GRACE mission, NASA has shown interest in gravity field mapping satellites. The next decade will see many new earth-observing satellites including NI-SAR (formerly DESDynI). These satellites will beam huge data sets back to earth, containing information about the ever changing surface of our planet. The hope is that this data will facilitate advancements in earthquake monitoring and forecasting. Virtual California (VC) is a computer program that simulates the California fault system, and with a few refinements it will model the time evolution of the gravity field around a fault system. It may be possible to use VC in the modeling chain for computing earthquake scenarios for many different earth-observing satellites. For example, VC could compute preand co-seismic sea level change data for undersea subduction zones. These data sets can be analyzed by missions employing the GNSS (Global Navigation Satellite System), which is currently being discussed as a possible contributor to a tsunami early warning system. To make these advancements we must understand how the patterns in the data relate to seismic activity. I propose using Virtual California to determine the required sensitivity and resolution for satellite-based seismic gravity field monitoring, to reveal the connection between gravity change patterns and the onset of seismic activity, and to develop advanced forecasting techniques for California’s fault system.
Deposition of trans Fatty Acid from Industrial Sources and Its Effect on Different Growth Phases in Rats

Although the effects of trans fatty acids (TFA) from industrially produced sources (IP-TFA), such as partially hydrogenated vegetable oil, are reported, their implications on metabolism and growth are still not fully disclosed. In this study, female Wistar rats were assigned to control diet (AIN-93G) or Trans diet groups (5% IP-TFA) after gestation. The male offspring were classified and grouped as infant, weanling, and young adult (YA) rats (n = 10), and received the same control or Trans diets throughout their life span. Samples of abdominal adipose tissue, liver and plasma were collected to determine fatty acid profile and fasting glycemia. Morphometric analysis of the liver and hepatosomatic index determination were conducted. Deposition of TFA was observed in the liver, adipose tissue and plasma of IP-TFA-fed rats. Fasting glycemia concentration was higher in Trans YA rats than in the control YA group (p = 0.004). A higher accumulation of fat was observed in the liver of the Trans group than in the control group during the three phases. Hepatosomatic index was higher in the YA Trans group than in the YA control group (p < 0.05). Dietary TFA was deposited in the tissues and plasma and raised fasting glucose in growing rats.
Expression of a gene family in the dimorphic fungus Mucor racemosus which exhibits striking similarity to human ras genes

Sporulation, spore germination, and yeast-hypha dimorphism in the filamentous fungus Mucor racemosus provide useful model systems to study cell development in eucaryotic cells. Three RAS genes (MRAS1, MRAS2, and MRAS3) from M. racemosus have been cloned, and their nucleotide sequences have been determined. The predicted amino acid sequences and the sizes of the three MRAS proteins exhibit a high degree of similarity with other ras proteins, including that encoded by H-ras, which have been implicated in regulation of proliferation and development in eucaryotic cells by mediating signal transduction pathways. The MRAS proteins show conservation of functional domains proposed for ras proteins, including guanine nucleotide interaction domains, an effector domain, a binding epitope for neutralizing antibody Y13-259, and the COOH-terminal CAAX box, which is a site of thiocylation and membrane attachment. Amino acid sequences unique to each MRAS protein occur adjacent to the CAAX box, consistent with the location of the hypervariable region in other ras proteins. Northern (RNA) analysis was used to study expression of the three MRAS genes in relation to cell development. Gene-specific probes for two of these genes, MRAS1 and MRAS3, hybridized to different 1.3-kb mRNA transcripts. The accumulation of these transcripts depended on the developmental stage, and this pattern was different between the two MRAS genes. No transcript for MRAS2 was detected in the developmental stages examined. The unique patterns of MRAS transcript accumulation suggest that individual MRAS genes and proteins may play distinct roles in cell growth or development.
Temporomandibular disorders treatment : comparison of home exercise and manual therapy

Address correspondence to: Prof. Dr. Nevin Ergun Hacettepe University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, 06100 Samanpazarı, Ankara, Türkiye E-mail: nergun@hacettepe.edu. tr Purpose: The aim of this study was to compare the effectiveness of home exercises therapy (HT) and manual therapy (MT) in patients with temporomandibular disorders (TMD) after 4weeks of intervention period. Methods: Forty patients with TMD with myofascial pain and/or anterior disc displacement with reduction were randomly divided into two groups: HT (N=20) and MT (N=20) groups. The HT group received education and postural exercises. The MT group received education, postural exercises, and temporomandibular joint and soft tissue mobilization. Pain intensity and head posture were measured before and after the treatment. Results: Compared with the baseline, both interventions were found to be significantly improved visual analog scale (VAS) and head posture after the treatment (p<0.05). The VAS decreased and head posture improved. Between the groups, the MT group showed significant changes in both parameters (p<0.05). Conclusions: The MT with HT was more effective for patients with TMD.
Phase-unwrapping of differential phase-contrast data using attenuation information

Phase-contrast imaging approaches suffer from a severe problem which is known in Magnetic Resonance Imaging (MRI) and Synthetic Aperture Radar (SAR) as phase-wrapping. This work focuses on an unwrapping solution for the grating based phase-contrast interferometer with X-rays. The approach delivers three types of information about the x-rayed object - the absorption, differential phase-contrast and dark-field information whereas the observed differential phase values are physically limited to the interval (-π, π]; values higher or lower than the interval borders are mapped (wrapped) back into it. In contrast to existing phase-unwrapping algorithms for MRI and SAR the presented algorithm uses the absorption image as additional information to identify and correct phase-wrapped values. The idea of the unwrapping algorithm is based on the observation that at locations with phase-wrapped values the contrast in the absorption image is high and the behavior of the gradient is similar to the real (unwrapped) phase values. This can be expressed as a cost function which has to be minimized by an integer optimizer. Applied on simulated and real datasets showed that 95.6% of phase-wraps were correctly unwrapped. Based on the results we conclude that it is possible to use the absorption information in order to identify and correct phase-wrapped values.