Miracle-dz/UniFAR-FTUs huggingface dataset:
Neuro-Metabolite Changes in a Single Season of University Ice Hockey Using Magnetic Resonance Spectroscopy

Background: Previous research has shown evidence for transient neuronal loss after repetitive head impacts (RHI) as demonstrated by a decrease in N-acetylaspartate (NAA). However, few studies have investigated other neuro-metabolites that may be altered in the presence of RHI; furthermore, the relationship of neuro-metabolite changes to neurocognitive outcome and potential sex differences remain largely unknown. Objective: The aim of this study was to identify alterations in brain metabolites and their potential association with neurocognitive performance over time as well as to characterize sex-specific differences in response to RHI. Methods: 33 collegiate ice hockey players (17 males and 16 females) underwent 3T magnetic resonance spectroscopy (MRS) and neurocognitive evaluation before and after the Canadian Interuniversity Sports (CIS) ice hockey season 2011–2012. The MRS voxel was placed in the corpus callosum. Pre- and postseason neurocognitive performances were assessed using the Immediate Post-Concussion Assessment and Cognitive Test (ImPACT). Absolute neuro-metabolite concentrations were then compared between pre- and postseason MRS were (level of statistical significance after correction for multiple comparisons: p < 0.007) and correlated to ImPACT scores for both sexes. Results: A significant decrease in NAA was observed from preseason to postseason (p = 0.001). Furthermore, a trend toward a decrease in total choline (Cho) was observed (p = 0.044). Although no overall effect was observed for glutamate (Glu) over the season, a difference was observed with females showing a decrease in Glu and males showing an increase in Glu, though this was not statistically significant (p = 0.039). In both males and females, a negative correlation was observed between changes in Glu and changes in verbal memory (p = 0.008). Conclusion: The results of this study demonstrate changes in absolute concentrations of neuro-metabolites following exposure to RHI. Results suggest that changes in Glu are correlated with changes in verbal memory. Future studies need to investigate further the association between brain metabolites and clinical outcome as well as sex-specific differences in the brain's response to RHI.
Resistance to Tomato Yellow Leaf Curl Virus in Tomato Germplasm

Tomato yellow leaf curl virus (TYLCV) is a virus species causing epidemics in tomato (Solanum lycopersicum) worldwide. Many efforts have been focused on identification of resistance sources by screening wild tomato species. In many cases, the accession numbers were either not provided in publications or not provided in a consistent manner, which led to redundant screenings. In the current study, we summarized efforts on the screenings of wild tomato species for TYLCV resistance from various publications. In addition, we screened 708 accessions from 13 wild tomato species using different inoculation assays (i.e., whitefly natural infection and Agrobacterium-mediated inoculation) from which 138 accessions exhibited no tomato yellow leaf curl disease (TYLCD) symptoms. These symptomless accessions include 14 accessions from S. arcanum, 43 from S. chilense, 1 from S. chmielewskii, 28 from S. corneliomulleri, 5 from S. habrochaites, 4 from S. huaylasense, 2 from S. neorickii, 1 from S. pennellii, 39 from S. peruvianum, and 1 from S. pimpinellifolium. Most of the screened S. chilense accessions remained symptomless. Many symptomless accessions were also identified in S. arcanum, S. corneliomulleri, and S. peruvianum. A large number of S. pimpinellifolium accessions were screened. However, almost all of the tested accessions showed TYLCD symptoms. Further, we studied allelic variation of the Ty-1/Ty-3 gene in few S. chilense accessions by applying virus-induced gene silencing and allele mining, leading to identification of a number of allele-specific polymorphisms. Taken together, we present a comprehensive overview on TYLCV resistance and susceptibility in wild tomato germplasm, and demonstrate how to study allelic variants of the cloned Ty-genes in TYLCV-resistant accessions.
Manifestation of topological transitions in a multi-terminal Josephson junction

We study nonequilibrium (NE) transport in four-terminal (three-terminal) topological superconductor (SC)-quantum dot (QD) topological superconductor junctions, where the QD is connected via tunneling barriers to the two TS leads and two (one) normal leads (N), respectively. For the four-terminal junction, we find that when increasing the Zeeman field from 0 to a critical value, the supercurrent profile evolves from a typical s-wave pattern to a pure p-wave pattern. In addition, by analyzing the zero-phase difference supercurrent as a function of voltage applied to the normal leads and the Zeeman field h applied to the SC, the low-momentum gap can be inferred by utilizing the fact that the emergence of a tunneling-induced current should be satisfied under the condition . For the three-terminal junction, the NE supercurrent can reveal the quasi-Andreev bound state by exploiting the Andreev reflection process-induced current occurring between the N and SC. Our findings provide an arguably easier route for manifesting the topological phase transition by observing the gap collapse and then reopening as the Zeeman field increases through multi-terminal NE transport.
Study on Leaf Segmentation Using K-Means and K-Medoid Clustering Algorithm for Identification of Disease

The aim of this paper is to study and compare the analysis of the most commonly used clustering algorithms like K-means and K-medoids based on their basic approach. Clustering is a common method used to segment the images. It is the process of grouping similar objects into different clusters or more precisely, the partitioning of a data set into subsets according to some defined distance measure. It is an unsupervised learning technique, which groups the data in large data sets into different patterns and structures by simple measures. It is widely used in many fields, including machine learning, data mining, pattern recognition, image analysis and bioinformatics. In this research clustering algorithms K-means and K-Medoids were examined and analyzed. From the results, it is found that K-means performs well in situations when the disease is easily divisible from the leaf as it calculate the distance based on the means value.
Molecular prevalence of human papillomavirus infection among Iranian women with breast cancer.

BACKGROUND The etiology and molecular mechanisms involved in the development of breast cancer still remain poorly understood. Some epidemiological studies have shown an association between human papillomavirus (HPV) and breast cancer. However, the findings are controversial. OBJECTIVE Our study was aimed to investigate the presence of HPV DNA in breast carcinomas of Iranian women. METHODS In total, 72 samples of formalin-fixed paraffin-embedded (FFPE) tissues of breast cancer collected between December 2014 and April 2016 were examined. HPV DNA detection was performed by nested-PCR assay. Next, positive samples were subjected to genotyping by the CLART HPV2 microarray system. All statistical analysis was carried out using SPSS v.18. 0. RESULTS HPV DNA was detected in 4/72 (5.55%) samples. Clinical factors were not statistically associated with HPV presence. However, CLART HPV2 microarray assay failed to determine the genotype of any positive samples. CONCLUSION The low frequency of HPV detected in our study does not support an association between breast carcinoma and HPV infection. However, it is possible that HPV may be responsible for breast carcinogenesis only in small percentage of all breast cancer.
Clinical and Immunological Characteristics of Human Infections With H5N6 Avian Influenza Virus

BACKGROUND H5N6 avian influenza virus (AIV) has caused sporadic, recurring outbreaks in China and Southeast Asia since 2013, with 19 human infections and 13 deaths. Seventeen of these infections occurred since December 2015, indicating a recent rise in the frequency of H5N6 cases. METHODS To assess the relative threat of H5N6 virus to humans, we summarized and compared clinical data from patients infected with H5N6 (n = 19) against data from 2 subtypes of major public health concern, H5N1 (n = 53) and H7N9 (n = 160). To assess immune responses indicative of prognosis, we compared concentrations of serum cytokines/chemokines in patients infected with H5N6, H5N1, H7N9, and 2009 pandemic H1N1 and characterized specific immune responses from 1 surviving and 2 nonsurviving H5N6 patients. RESULTS H5N6 patients were found to have higher incidences of lymphopenia and elevated alanine aminotransferase and lactate dehydrogenase levels compared with H5N1 and H7N9 patients. Hypercytokinemia was detected at substantially higher frequencies from H5N6 patients compared to those infected with other AIV subtypes. Evaluation of adaptive immunity showed that both humoral and cellular responses could be detected in the H5N6-infected survivor, but cellular responses were absent in the nonsurvivors. In addition, the surviving patient had lower concentrations of both pro- and anti-inflammatory cytokines/chemokines compared to the nonsurvivors. CONCLUSIONS Our results support that H5N6 virus could potentially be a major public health threat, and suggest it is possible that the earlier acquisition of cellular immunity and lower concentrations of cytokines/chemokines contributed to survival in our patient. Analysis of more patient samples will be needed to draw concrete conclusions.
Average of trial peaks versus peak of average profile: impact on change of direction biomechanics

ABSTRACT The aims of this study were twofold: firstly, to compare lower limb kinematic and kinetic variables during a sprint and 90° cutting task between two averaging methods of obtaining discrete data (peak of average profile vs. average of individual trial peaks); secondly, to determine the effect of averaging methods on participant ranking of each variable within a group. Twenty-two participants, from multiple sports, performed a 90° cut, whereby lower limb kinematics and kinetics were assessed via 3D motion and ground reaction force (GRF) analysis. Six of the eight dependent variables (vertical and horizontal GRF; hip flexor, knee flexor, and knee abduction moments, and knee abduction angle) were significantly greater (p ≤ 0.001, g = 0.10–0.37, 2.74–10.40%) when expressed as an average of trial peaks compared to peak of average profiles. Trivial (g ≤ 0.04) and minimal differences (≤ 0.94%) were observed in peak hip and knee flexion angle between averaging methods. Very strong correlations (ρ ≥ 0.901, p < 0.001) were observed for rankings of participants between averaging methods for all variables. Practitioners and researchers should obtain discrete data based on the average of trial peaks because it is not influenced by misalignments and variations in trial peak locations, in contrast to the peak from average profile.
Poplar miR472a targeting NBS-LRRs is involved in effective defence against the necrotrophic fungus Cytospora chrysosperma

The hemibiotroph Colletotrichum gloeosporioides and the necrotroph Cytospora chrysosperma cause poplar foliage and stem disease, respectively, resulting in substantial economic losses. In this study, Populus trichocarpa ptc-miR472a was down-regulated in leaves treated with salicylic acid, jasmonic acid (JA) or bacterial flagellin (flg22). Here, ptc-miR472a and a short tandem target mimic (STTM) of miR472a were overexpressed in P. alba × P. glandulosa, and overexpression lines of miR472a and silenced lines of STTM472a were generated. Compared with the STTM472a and wild type lines, lower reactive oxygen species accumulation was detected in miR472a overexpressing plants treated with flg22, C. gloeosporioides or C. chrysosperma. In addition, the miR472a overexpressing lines exhibited the highest susceptibility to the hemibiotroph, C. gloeosporioides, but the highest effective defence response to the necrotroph, C. chrysosperma. The JA/ethylene marker gene ERF1 was rapidly up-regulated in miR472a overexpressing plants. Furthermore, five phased, secondary, small interfering RNAs (phasiRNAs) were confirmed in the miR472a overexpressing and STTM472a lines, triggering phasiRNAs predicted to enhance NBS-LRR silencing. Taken together, our results revealed that ptc-miR472a exerts a key role in plant immunity to C. gloeosporioides and C. chrysosperma by targeting NBS-LRR transcripts. This study provides a new strategy and method in plant breeding to improve plant disease resistance.
‘Adding another spinning plate to an already busy life’. Benefits and risks in patient partner–researcher relationships: a qualitative study of patient partners’ experiences in a Canadian health research setting

Objective To better understand, based on patient partners’ experiences, benefits and risks in patient partner–researcher relationships in a health research setting. Design Qualitative interviews with thematic analysis informed by a relational ethics lens. Setting A multidisciplinary health research centre in Vancouver, Canada. This study was codeveloped by patient partners and researchers at the centre. Participants 22 people living with arthritis, with experience as members of a patient advisory board at the research centre from 1 month to 10 years. Results We identified three main themes: (1) Being Heard: Participants had experienced uncomfortable emotions (eg, feelings of insecurity) in their relationships with researchers. The discomfort, however, was minimised by the demonstration of mutual respect in their interactions. Specifically, participants valued environments without a hierarchy between patient partners and researchers, where contributions of each party were considered equally important, and where patients’ voices were heard; (2) Cobuilding social relations: Participants valued building social relations with researchers beyond their expected interactions as partners in research and (3) Adding another spinning plate to an already busy life: Participants valued relationships with researchers who had cocreated environments that minimised the risks of physical and emotional impacts (eg, fatigue, stress, guilt) on them while juggling multiple obligations, priorities and their health. Conclusions Findings provide valuable insights to guide relationship building between patient partners and researchers. Informed by a relational ethics lens, these findings are a critical step in supporting an ethically sound practice of patient engagement in research that prioritises patients’ perspectives.
Safety and Efficacy of a Fixed Combination Halobetasol and Tazarotene Lotion in the Treatment of Moderate-to-Severe Plaque Psoriasis: A Pooled Analysis of Two Phase 3 Studies.

BACKGROUND Topical corticosteroids (TCS) are the mainstay of psoriasis treatment. Safety concerns may limit use. Combination with tazarotene may optimize efficacy and minimize safety and tolerability concerns. OBJECTIVE Investigate safety and efficacy of halobetasol propionate 0.01%/tazarotene 0.045% (HP/TAZ) lotion in moderate-to-severe plaque psoriasis. METHODS Two multicenter, randomized, double-blind, vehicle-controlled phase 3 studies (N=418). Subjects randomized (2:1) to HP/TAZ lotion or vehicle once-daily for 8 weeks, 4-week follow-up. Primary efficacy assessment: treatment success (at least a 2-grade improvement from baseline in IGA score and 'clear' or 'almost clear'). Safety and treatment emergent AEs evaluated throughout. RESULTS HP/TAZ lotion demonstrated statistically significant superiority over vehicle as early as week 2 (P equals 0.002). By week 8, 40.6% of subjects were treatment successes compared with 9.9% on vehicle (P less than 0.001). A third of subjects remained treatment successes post-treatment. HP/TAZ lotion was also superior in reducing psoriasis signs and symptoms, and Body Surface Area (BSA) involvement. Most frequently reported treatment related AEs were contact dermatitis (6.3%), application site pain (2.6%), and pruritus (2.2%). LIMITATIONS No data were collected beyond the 4-week follow-up. CONCLUSIONS HP/TAZ lotion provides synergistic efficacy that is both rapid and sustained, with good tolerability and safety over 8 weeks use. J Drugs Dermatol. 2018;17(8):855-861.
Handling the inpatient's hospital ‘Career’ – Are nurses laying the groundwork for healthy meal and nutritional care transitions?

This qualitative study examined hospital nurses' methods in handling meal and nutrition care during inpatient time, with an underlying focus on undernourished older adult. Observations and interviews were used to document nurses' methods through the span of a transition (defined by an entry, passage, and exit). The study finds inconsistencies in care methods due to institutional processes restricting both mealtime care and nutritional logging of information throughout hospitalization. It is concluded that the consequences of these inconsistencies must be recognized and that new approaches to meals and nutritional care should be introduced in order to provide greater flexibility. Based on the assumption that mobilizing patient resources is pivotal for meal and nutritional care, it is argued that it may be important to mobilize patient resources during mealtime and in nutritional logging of information in order to increase the visibility of meal and nutritional care in patient transitions within the institution and across settings. Both nurses' methods and institutions developmental initiatives regarding meal and nutritional care need to accommodate the differences between what in this paper is defined as social-bodily care and text-based care. This could be met through care methods that take place with, more than for the patient.
MoSART: Mobile Spatial Augmented Reality for 3D Interaction With Tangible Objects

In this paper we introduce MoSART, a novel approach for Mobile Spatial Augmented Reality on Tangible objects. MoSART is dedicated to mobile interaction with tangible objects in single or collaborative situations. It is based on a novel “all-in-one” Head-Mounted Display (AMD) including a projector (for the SAR display) and cameras (for the scene registration). Equipped with the HMD the user is able to move freely around tangible objects and manipulate them at will. The system tracks the position and orientation of the tangible 3D objects and projects virtual content over them. The tracking is a feature-based stereo optical tracking providing high accuracy and low latency. A projection mapping technique is used for the projection on the tangible objects which can have a complex 3D geometry. Several interaction tools have also been designed to interact with the tangible and augmented content, such as a control panel and a pointer metaphor, which can benefit as well from the MoSART projection mapping and tracking features. The possibilities offered by our novel approach are illustrated in several use cases, in single or collaborative situations, such as for virtual prototyping, training or medical visualization.
Quadriceps Strength and Functional Performance After Anterior Cruciate Ligament Reconstruction in Professional Soccer players at Time of Return to Sport.

Herrington, L, Ghulam, H, and Comfort, P. Quadriceps strength and functional performance after anterior cruciate ligament reconstruction in professional soccer players, at time of return to sport. J Strength Cond Res XX(X): 000-000, 2018-Poor quadriceps strength has been associated with poor outcome after anterior cruciate ligament (ACL) reconstruction (ACLR). This study aims to assess quadriceps strength, muscle inhibition, and hop test performance in professional soccer players after ACLR. Fifteen professional soccer players (age 22.3 ± 3.1 years, body mass 81.0 ± 11.5 kg, and height 1.75 ± 0.1 m) who had undergone ACLR participated. Isometric, eccentric, and concentric quadriceps strength was assessed, along with quadriceps inhibition and single and cross-over hop performance, at the time of return to full-time unrestricted play. In comparison with the uninjured leg, the ACLR leg demonstrated large significant (d ≥ 0.84, p < 0.01) deficits in isometric, eccentric, and concentric quadriceps strength, quadriceps inhibition, and hop distance. Over 80% of the players failed to exceed the limb symmetry criteria of ≥90% for strength tests, although 75% of the cohort passed the ≥90% criteria for hop tests. The outcome from ACLR in professional soccer players who received full-time intensive rehabilitation has not previously been reported in detail. There were significant deficits in quadriceps strength at the time of return to sport, whereas hop testing, a commonly used outcome measure, failed to show the same levels of deficit. These deficits in quadriceps function may have implications for the development of ongoing knee symptoms and risk of future ACL injury. If this proves to be the case, then it would seem that greater attention should be paid to re-establishing full quadriceps strength before returning to unrestricted sporting activity.
Investigations of relationships between alterations of the gastrointestinal tract caused by feeding variously processed feedstuffs and blood and immunological traits of broilers

&NA; The influence of variously processed feedstuffs on the gastrointestinal tract, various blood parameters, and T cell subsets of different localizations was investigated in 36 broilers. Birds were fed a similarly composed feed mixture differing in particle size (coarse vs. fine). Feedstuffs with different particle size distribution were additionally hydrothermally treated (HTT) (without—non‐compacted, pelleted, expanded, and pelleted). The HTT affected BW at slaughtering day and feed intake (P < 0.001). Birds fed non‐compacted feed consumed less feed and were lighter than animals of other feeding groups irrespective of grinding fineness. Proventricular size was influenced by HTT (P < 0.001) but not the weight. Generally, feeding of pelleted feed increased proventricular size. Gizzard weight and length was affected by particle size and HTT (P < 0.01). Non‐compacted feed resulted in heavier but shorter gizzards compared to other feeds except for finely ground expanded and pelleted feed. Organ traits of gizzard and proventriculus were strongly related to the feed intake. The jejunum was heavier in birds fed expanded and pelleted feed compared to animals fed solely pelleted feed (P = 0.030). The intestinal segment weight to length ratio (WL ratio) of duodenum, jejunum, and total small intestine was affected by HTT (P < 0.01). Generally, non‐compacted feed resulted in lowest WL ratios regardless of the particle size distribution. Feeding variously processed feedstuffs also affected white blood cells, blood sodium, and chloride concentrations (P < 0.05) and tended to influence blood carbon dioxide partial pressure and blood total carbon dioxide levels (P < 0.1) in venous blood. Subsets of CD4/CD8 double negative T cells of caecal tonsils were influenced by HTT (P < 0.043). Non‐compacted feed tended to increase these subsets in this localization compared to other feeds. In conclusion, the present study shows that an increased feed intake provoked by feed compaction evoke proventricular and ventricular alterations. Furthermore, feeding of variously processed feedstuffs influences the acid base homeostasis and the local immune system of caecal tonsils.