Miracle-dz/UniFAR-FTUs huggingface dataset:
CMTR1 is recruited to transcription start sites and promotes ribosomal protein and histone gene expression in embryonic stem cells

CMTR1 (cap methyltransferase 1) catalyses methylation of the first transcribed nucleotide of RNAPII transcripts (N1 2’-O-Me), creating part of the mammalian RNA cap structure. In addition to marking RNA as self, N1 2’-O-Me has ill-defined roles in RNA expression and translation. Here we investigated the gene specificity of CMTR1 and its impact on RNA expression in embryonic stem cells. Using chromatin immunoprecipitation, CMTR1 was found to bind to transcription start sites (TSS) correlating with RNAPII levels, predominantly binding at histone genes and ribosomal protein (RP) genes. Repression of CMTR1 expression resulted in repression of RNAPII binding at the TSS and repression of RNA expression, particularly of histone and RP genes. In correlation with regulation of histones and RP genes, CMTR1 repression resulted in repression of translation and induction of DNA replication stress and damage. Indicating a direct role for CMTR1 in transcription, addition of recombinant CMTR1 to purified nuclei increased transcription of the histone and RP genes. CMTR1 was found to be upregulated during neural differentiation and there was an enhanced requirement for CMTR1 for gene expression and proliferation during this process. We highlight the distinct roles of the cap methyltransferases RNMT and CMTR1 in target gene expression and differentiation.
Exploring Rater Accuracy Using Unfolding Models Combined with Topic Models: Incorporating Supervised Latent Dirichlet Allocation

ABSTRACT Objectively scoring constructed-response items on educational assessments has long been a challenge due to the use of human raters. Even well-trained raters using a rubric can inaccurately assess essays. Unfolding models measure rater’s scoring accuracy by capturing the discrepancy between criterion and operational ratings by placing essays on an unfolding continuum with an ideal-point location. Essay unfolding locations indicate how difficult it is for raters to score an essay accurately. This study aims to explore a substantive interpretation of the unfolding scale based on a supervised Latent Dirichlet Allocation (sLDA) model. We investigate the relationship between latent topics extracted using sLDA and unfolding locations with a sample of essays (n = 100) obtained from an integrated writing assessment. Results show that (a) three latent topics moderately explain (r 2 = 0.561) essay locations defined by the unfolding scale and (b) failing to use and/or cite the source articles led to essays that are difficult-to-score accurately.
AI weapon systems in future war operations; strategy, operations and tactics

Abstract In the future, at the strategic, operational and tactical level of warfare, the substitution of the human will and action by autonomous AI weapon systems appears quite probable. These systems are already being used and have the capability to successfully deal with threats faster than humans. The countering of AI weapon systems will pose a great challenge in a future war. In this article, the case is made that for the AI weapon systems to be defeated, unconventional cognition will be required.
Swallowing sparing intensity modulated radiotherapy versus standard parotid sparing intensity-modulated radiotherapy for treatment of head and neck cancer: a randomized clinical trial

Abstract Background Dysphagia is a distressing symptom during and after radiotherapy treatment in head and neck cancer (HNC) patients. The objective of this prospective study was to investigate whether swallowing sparing intensity modulated radiotherapy (SW-IMRT) reduces the occurrence of swallowing dysfunction compared to the standard IMRT (ST-IMRT). Methods We randomized, planned, and treated patients with HNC who needed whole neck irradiation using the simultaneous integrated boost (SIB) IMRT technique. Doses of 70, 60, and 54 Gy (over 33 daily fractions) were prescribed to the primary tumor, high-risk and low-risk regions, respectively. The postoperative cases received 60 and 54 Gy (over 30 daily fractions) to the high-risk planning target volume (PTV) and low-risk PTV. We contoured organs at risk related to swallowing dysfunction (SWOARs) in all cases. In the ST-IMRT group, parotids only were spared. In the SW-IMRT group, parotids and SWOARs outside the high-risk PTV were spared. Assessment of dysphagia included clinical and instrumental evaluation. Results One hundred forty-six patients ended their radiotherapy treatment. Dose distribution showed comparable PTV coverage and no difference in parotid glands sparing between the two groups. SWOARs dose reduction with SW-IMRT differs according to tumor location and its overlap with SWOARs. Using different assessment methods, SW-IMRT was associated with a lower occurrence of dysphagia up to one year after treatment. There was no difference between the two groups regarding acute dysphagia (p = 0.262), overall survival (p = 0.811), and disease-free survival (p = 0.876). Conclusion SW-IMRT is significantly better than ST-IMRT regarding a physician-rated and objective assessment of swallowing dysfunction at short- and long-term post-treatment follow-up.
Railway Passenger Station Operation Combined Simulation Model Based on TCPN

A timed colored Petri net(TCPN) simulation model is presented to describe the operating process of railway passenger stations.The TCPN model uses a route conflicting graph to define the station yard in order to solve the problems such as complex modeling process,limited applicable range,and inefficiency,in the system simulation of the current railway station operation.The results of the simulation example show that the TCPN model has the advantages of stability and reusability,and can be widely used in the simulation and optimization of passenger railway stations including high-speed railway stations;the conflicting graph is an accurate presentation of station yard routes,which has the same accuracy as the design of station yard construction,and its precision can reach a millimeter level;compared to the traditional modeling method,the progress of the conflicting graph modeling is more efficient.In the given example,maximum loading rates at station throat area and arrival-departure tracks are 70% and 35%,respectively;on-schedule rates of arrival and departure are 100% and 91%,respectively.
Reading in the Intermediate Grades

Characteristics of Children Affecting Development in and through Reading Physically, the intermediate-grade period is a time of participation in games of skill; socially, it is a time of interest in relationships with other children; intellectually, a time of curiosity about the world, past and present, and even to the limits of outer space. Gradually, the children become involved in a variety of engaging activities, some of which tend to provide motivations for reading, while others tend to limit the time which may be devoted to reading. Increasing maturity brings home responsibilities, too, which infringe upon reading time. 1 In intellectual development, the child is increasingly able to understand cause-and-effect relationships, to form generalizations, and to think logically. He makes an increasingly clear distinction between fact and fancy. When problems are within his experience, his thinking appears to be like that of an adult. In his progress toward independence he shows a desire to initiate, plan, compete intellectually, reason matters through, and verify. " A child of this age may be an omnivorous reader or a reluctant one, preferring stories involving adventure, mystery, animals, humor,
Metropolis: 1985

TODAY'S youth faces a new American revolution—a revolution that I venture to predict will be as significant to the survival and growth of our nation as the battle for independence through which our nation was born. But unlike that earlier revolt, waged against foreign tyranny, the new American revolt will be waged against an internal enemy, for today the people in American cities and suburbs are caught up in a struggle against the rising tyranny of urban slums and blight, urban congestion, deteriorating urban transportation, and the social breakdown of whole urban communities. The fight now being joined is aimed at freeing a growing segment of the American population from the slavery of slum life and freeing all of us from the alarming drains on our social and economic strengths that result from slum-burdened cities.
HADLN: Hybrid Attention-Based Deep Learning Network for Automated Arrhythmia Classification

In recent years, with the development of artificial intelligence, deep learning model has achieved initial success in ECG data analysis, especially the detection of atrial fibrillation. In order to solve the problems of ignoring the correlation between contexts and gradient dispersion in traditional deep convolution neural network model, the hybrid attention-based deep learning network (HADLN) method is proposed to implement arrhythmia classification. The HADLN can make full use of the advantages of residual network (ResNet) and bidirectional long–short-term memory (Bi-LSTM) architecture to obtain fusion features containing local and global information and improve the interpretability of the model through the attention mechanism. The method is trained and verified by using the PhysioNet 2017 challenge dataset. Without loss of generality, the ECG signal is classified into four categories, including atrial fibrillation, noise, other, and normal signals. By combining the fusion features and the attention mechanism, the learned model has a great improvement in classification performance and certain interpretability. The experimental results show that the proposed HADLN method can achieve precision of 0.866, recall of 0.859, accuracy of 0.867, and F1-score of 0.880 on 10-fold cross-validation.
The Student

Introduction The student, seen as an individual or as a group member, has in recent years been re-established as an important segment in the educational realm. The reawakened cognizance of the student, an emphasis following the last World War, has gone through a transi. cion from centering in "Who should go to college? " to "Who should go where and for what? " Some writers have noted a trend toward greater concern and understanding through extended use of improved psychological measurement.1 In the investigations on undergraduate students, this trend is perhaps even more pronounced within the context of a single profession. Recent annual conferences of the Association of American Medical Colleges have been, in part, directed to the topic of the student who enters medical training.l1 The growing interest in the person who applied and was accepted for training in other major professions will be made apparent later in the chapter. The problem of selection and admission is obviously interwoven with the well-researched question of prediction, a concern of many studies of previous decades. Though we have not appreciably improved the forecasting of academic achievement of students, the
Emotional Blackmail

Using a telling metaphor, Professor Caspi here presents a small anthology of instances in which people deal with tension by exploiting negative and irrelevant emotions. Readers may not agree with his charge that “blackmail” of the sort described is prevalent in our classroom; but this remains a cautionary tale. Dr. Caspi wishes to thank Yona Sternberg for her contributions to the article, Zvi Lamm for his remarks, and Dennis Silk for his stylization.
A STUDY ON THE STANDARD OF THE RATIONALITY OF REGIONAL INDUSTRIAL STRUCTURE BASED ON ENVIRONMENTS AND RESOURCES

Industrial structure is a key link of man's action to ecological system. Its combining type and intensity determine, to a great extent, the economic benefit, resources utilization efficiency and stress on environment. So how to select or construct a standard to assess the rationality of industrial structure is more important, especially nowadays our country is adjusting the industrial structure to realize the sustainable economic growth. After retrospection of the previous research on this standard home and abroad, this paper put forward a new standard, comprehensive relative potential(CRP) which put more attention to the thoughts about environments and resources, to judge the rationality of industrial structures. Then the paper discussed the concept and the quantifying model, especially the method of ascertaining the weighted coefficient values for evaluate indicators, of comprehensive relative potential. On the basis of the study of CRP theory, this paper took Fuzhou city as a case study. In view of the thought about environments and resources and based on relative statistics, the paper compared the emissions of wastes and the consumptions of energy by industry sectors and analyzed the city's industrial structure according to the quantifying method of CRP mentioned above and the conclusions were as follows: (1) Production supply of electric power, gas water, papermaking paper products, petroleum processing coking were the main industries, of which the CRP value were very low(less than 10), that meant these industries consumed a large amount of natural resources, with higher compositions of wastes comparing with other industries such as machinery and equipment manufacturing industry. (2) On the whole, the industrial structure in Fuzhou was relatively reasonable. Contraposing the assessment result above, the paper raised the train of thoughts about readjusting the city's industrial structure: Fuzhou should inspire the development of high CRP sectors including chemical fiber, smelting and pressing of ferrous metals, machine building, electric machinery electronic equipment manufacturing while restricted the development of sectors which have low CRP values mentioned above. Through the case study, the paper draw the conclusion that we can judge the rationality by calculating the CRP value of industry sectors and the CRP theory is a useful means to industrial structure adjustment if we can build a reasonable index system.
Application of Gabion Retaining Wall in Wuxi-Shiyan Highway

There are many tall retaining structures along mountainous highways,most of them have the problems such as complicated geological conditions,rugged topography and lack of rough materials.So it is very difficult to design and build the tall retaining structures in the places.Gabion can solve preferably the problems mentioned above because of its unique structural performance and preferable durability.Take the example of a test segment of K17+300 m～K17+350 m of Wuxi-Shiyan highway,which had complicated geological condition,rugged topography and lower ground bearing capacity,the main technique and processing methods in the course of construction are discussed in detail from points of view of preconstruction stage and construction control.The deformation characters and stability of the finished gabion retaining wall are analyzed respectively by finite difference method and strength reduction method.Numerical analysis shows that,the deformation of gabion retaining wall is small,which was centralized in the middle of gabion retaining wall,and the gabion retaining wall had preferable self-stabilization and meet the requirements of design and construction.As a kind of new retaining structure,the gabion retaining wall,which gains more advantages compared with conventional tall retaining structures,can reduce construction cost of mountainous retaining structures.
Review of Perioperative Music Medicine: Mechanisms of Pain and Stress Reduction Around Surgery

Clinical-experimental considerations and an approach to understanding the autonomic basis of improved surgical outcomes using Perioperative Music Medicine (PMM) are reviewed. Combined surgical, psycho-physiological, and experimental perspectives on Music Medicine (MM) and its relationship to autonomic nervous system (ANS) function are discussed. Considerations are given to the inter-related perioperative effects of MM on ANS, pain, and underlying vagal and other neural circuits involved in emotional regulation and dysregulation. Many surgical procedures are associated with significant pain, which is routinely treated with post-operative opioid medications, which cause detrimental side effects and delay recovery. Surgical trauma shifts the sympathetic ANS to a sustained activation impairing physiological homeostasis and causing psychological stress, as well as metabolic and immune dysfunction that contribute to postoperative mortality and morbidity. In this article, we propose a plan to operationalize the study of mechanisms mediating the effects of MM in perioperative settings of orthopedic surgery. These studies will be critical for the implementation of PMM as a routine clinical practice and to determine the potential limitations of MM in specific cohorts of patients and how to improve the treatment.
Tranexamic Acid Administered During Off-Pump Coronary Artery Bypass Graft Surgeries Achieves Good Safety Effects and Hemostasis

Background Tranexamic acid (TXA) administered during off-pump coronary artery bypass (OPCAB) surgeries has achieved good blood control in small cohorts. We aimed to investigate the safety issues and hemostasis associated with TXA administration during OPCAB in a large retrospective cohort study. Methods This study included 19,687 patients with OPCAB from 2009 to 2019. A total of 1,307 patients were excluded because they were younger than 18 years or certain values were missing. Among the remaining 18,380 patients, 10,969 were in the TXA group and 7,411 patients were in the no-TXA group. There were 4,889 patients whose TXA dose was ≥50 mg/kg, and the remaining 6,080 patients had a TXA dose of <50 mg/kg. Propensity score matching (PSM) was performed between the TXA and no-TXA groups and between the high-dose and low-dose groups, and statistical analysis was performed. Results Tranexamic acid administration did not increase the risk of hospital death or thromboembolic events. Patients who administered TXA had less blood loss at 24 h (478.32 ± 276.41 vs. 641.28 ± 295.09, p < 0.001) and 48 h (730.59 ± 358.55 vs. 915.24 ± 390.13, p < 0.001) and total blood loss (989.00 ± 680.43 vs. 1,220.01 ± 720.68, p < 0.001) after OPCAB than the patients with non-TXA. Therefore, the risk of total blood exposure [odds ratio (OR) = 0.50, 95% CI 0.47–0.54, p < 0.001] or blood component exposure (p < 0.001) was decreased significantly in the patients who administered TXA. The TXA dosage did not impact the patient survival, thromboembolic events, or blood management. Conclusions The application of TXA was safe and provided blood control in patients with OPCAB, and the dosage did not affect these parameters.
OMICS Applications for Medicinal Plants in Gastrointestinal Cancers: Current Advancements and Future Perspectives

Gastrointestinal cancers refer to a group of deadly malignancies of the gastrointestinal tract and organs of the digestive system. Over the past decades, considerable amounts of medicinal plants have exhibited potent anticancer effects on different types of gastrointestinal cancers. OMICS, systems biology approaches covering genomics, transcriptomics, proteomics and metabolomics, are broadly applied to comprehensively reflect the molecular profiles in mechanistic studies of medicinal plants. Single- and multi-OMICS approaches facilitate the unravelling of signalling interaction networks and key molecular targets of medicinal plants with anti-gastrointestinal cancer potential. Hence, this review summarizes the applications of various OMICS and advanced bioinformatics approaches in examining therapeutic targets, signalling pathways, and the tumour microenvironment in response to anticancer medicinal plants. Advances and prospects in this field are also discussed.
A One-Armed Phase I Dose Escalation Trial Design: Personalized Vaccination with IKKβ-Matured, RNA-Loaded Dendritic Cells for Metastatic Uveal Melanoma

Uveal melanoma (UM) is an orphan disease with a mortality of 80% within one year upon the development of metastatic disease. UM does hardly respond to chemotherapy and kinase inhibitors and is largely resistant to checkpoint inhibition. Hence, further therapy approaches are urgently needed. To improve clinical outcome, we designed a trial employing the 3rd generation personalized IKKβ-matured RNA-transfected dendritic cell (DC) vaccine which primes T cells and in addition activates NK cells. This ongoing phase I trial [NCT04335890 (www.clinicaltrials.gov), Eudract: 2018-004390-28 (www.clinicaltrialsregister.eu)] investigates patients with treatment-naive metastatic UM. Monocytes are isolated by leukapheresis, differentiated to immature DCs, matured with a cytokine cocktail, and activated via the NF-κB pathway by electroporation with RNA encoding a constitutively active mutant of IKKβ. Three types of antigen-RNA are co-electroporated: i) amplified mRNA of the tumor representing the whole transcriptome, ii) RNA encoding driver mutations identified by exome sequencing, and iii) overexpressed non-mutated tumor antigens detected by transcriptome sequencing. This highly personalized DC vaccine is applied by 9 intravenous infusions in a staggered schedule over one year. Parallel to the vaccination, standard therapy, usually an immune checkpoint blockade (ICB) as mono (anti-PD-1) or combined (anti-CTLA4 and anti-PD-1) regimen is initiated. The coordinated vaccine-induced immune response encompassing tumor-specific T cells and innate NK cells should synergize with ICB, perhaps resulting in measurable clinical responses in this resistant tumor entity. Primary outcome measures of this trial are safety, tolerability and toxicity; secondary outcome measures comprise overall survival and induction of antigen-specific T cells.
Impacts of Stress and Risk Perception on Mental Health of College Students During the COVID-19 Pandemic: The Mediating Role of Coping Efficacy

Object In this study, we aimed to explore the influences of pandemic stress, risk perception, and coping efficacy on the mental health of Chinese college students during the COVID-19 pandemic. Methods A nationally representative sample of Chinese college students (N = 3,381, Mage = 20.85, SDage = 1.31) took part in an online survey during the COVID-19 pandemic. Correlation coefficients, structural equation modeling, and other statistical analysis methods were used for data analysis. Results (1) The Chinese college students' pandemic stress and perceived pandemic risk were found to be moderate (3.51 ± 0.83, 3.45 ± 0.94), whereas their perceived infection risk was lower (2.10 ± 0.67). Their mental health during the COVID-19 pandemic was found to be good (3.80 ± 0.73). (2) The quality of their mental health was significantly and negatively associated with pandemic stress, perceived pandemic risk, and perceived infection risk. The level of their mental health was significantly and positively associated with coping efficacy, and their coping efficacy was significantly and negatively associated with pandemic stress, perceived pandemic risk, and perceived infection risk. Conclusion Coping efficacy played a partial mediating role in the relationship between pandemic stress and mental health, coping efficacy played a partial mediating role in the relationship between perceived infection risk and mental health, and coping efficacy played a complete mediating role in the relationship between perceived pandemic risk and mental health. Our findings show the importance of fostering college students' coping efficacy to improve their mental health during the COVID-19 pandemic.