Miracle-dz/UniFAR-FTUs huggingface dataset:
Skin Remodeling Using Hyaluronic Acid Filler Injections in Photo-Aged Faces

BACKGROUND Hyaluronic acid (HA) filler is an important dermatological procedure. Although many studies have reported clinical improvement with this procedure, histology with morphometric evidence is not well documented. OBJECTIVE To evaluate the clinical and histological results of a HA filler injection and to quantify dermis remodeling at 3 and 9 months after HA injections into aged faces. MATERIALS AND METHODS Twenty patients were enrolled in this study. Hyaluronic acid filler was injected into the nasolabial folds and preauricular regions of the patients. Skin biopsies of the preauricular regions were performed before the procedure and at 3 and 9 months after the procedure. RESULTS Sixteen women (aged 40–50 years) completed the clinical study and demonstrated improvement for 12 months. Twenty patients completed the histologic studies. Morphologic evaluation showed increases in the epidermal layers. The morphometric study showed a statistically significant increase in collagen fibers at 3 and 9 months after the procedure (34.2% ± 31.5% and 39.5% ± 39.7%, respectively, p < .05). CONCLUSION Sustained clinical results for HA filler can be explained not only by the presence of HA gel on the dermis but also by the dermal remodeling induced by HA filler injected into the face.
Perceived Built Environment Characteristics of On-Campus and Off-Campus Neighborhoods Associated With Physical Activity of College Students

Abstract Objective: To identify differences in neighborhood environment and their association with physical activity (PA) levels of on-campus compared with off-campus students. Participants: Participants were 822 undergraduate students at a mid-sized mid-Atlantic university. Methods: Students completed the Neighborhood Environment Walkability Scale–Abbreviated and the International Physical Activity Questionnaire in October 2013. Results: Lower residential density, traffic safety, and crime scores and higher land-use mix diversity, aesthetics, and lack of parking scores were reported among on-campus residents. On-campus residents reported higher levels of active transportation PA, leisure PA, and total PA. Land-use mix diversity, aesthetics, and lack of cul-de-sacs were associated with physical activity level. Conclusion: The on-campus and off-campus environments differ in ways that may impact the ability of undergraduate students to be physically active. Strategies to promote continued active transportation and leisure PA are discussed.
The Impact of Work and Volunteer Hours on the Health of Undergraduate Students

Abstract Objective: To examine the impact of work and volunteer hours on 4 health issues among undergraduate college students. Participants: Full-time undergraduate students (N = 70,068) enrolled at 129 institutions who participated in the Spring 2011 American College Health Association–National College Health Assessment II survey. Methods: Multiple linear regression and binary logistic regression were used to examine work and volunteer hour impact on depression, feelings of being overwhelmed, sleep, and physical activity. Results: The impact of work and volunteer hours was inconsistent among the health outcomes. Increased work hours tended to negatively affect sleep and increase feelings of being overwhelmed. Students who volunteered were more likely to meet physical activity guidelines, and those who volunteered 1 to 9 hours per week reported less depression. Conclusions: College health professionals should consider integrating discussion of students' employment and volunteering and their intersection with health outcomes into clinical visits, programming, and other services.
Are drinking motives associated with sexual “hookups” among college student drinkers?

ABSTRACT Objective: This study examined associations between drinking motivation, alcohol use, and sexual hookups among college students. Participants: Participants (n = 755 Midwest college student drinkers; 61% female) ranged in age from 18 to 24. Methods: Participants completed online measures of alcohol involvement (use and motives) and sexual activity. Results: Alcohol use was positively linked to sexual hookups. Social and enhancement motives were positively and indirectly associated with sexual hookups via alcohol use. Drinking to cope had a direct association with sexual hookups. Social drinking was more strongly associated with hookups in men than in women, but both groups exhibited a positive association. Conclusions: This study is the first to highlight the relationships between distinct drinking motives and sexual risk behavior. The results indicate that specific motives may increase risk of sexual hookups both indirectly via alcohol use, as well as directly, at least among those that drink to cope with negative mood.
A Comprehensive Approach to Multimodal Facial Aesthetic Treatment: Injection Techniques and Treatment Characteristics From the HARMONY Study

BACKGROUND The HARMONY study is the first clinical trial to assess the impact of a global approach to facial rejuvenation with several minimally invasive modalities, using patient-reported outcome measures. OBJECTIVE Provide details of this treatment approach and describe investigators' experiences and recommendations based on this study. METHODS This multicenter, 4-month study evaluated subject satisfaction with and psychological impact of combined treatment with VYC-20L (Juvéderm Voluma XC), HYC-24L (Juvéderm Ultra XC), HYC-24L+ (Juvéderm Ultra Plus XC), onabotulinumtoxinA (Botox), and bimatoprost 0.3% ophthalmic solution (Latisse). Treatment-naive adults with moderate-to-severe facial lines and folds and eyelash hypotrichosis received on-label, staged treatment with fillers. Bimatoprost was self-administered once daily for 17 weeks from day 1. OnabotulinumtoxinA was administered for glabellar lines, crow's feet lines, or both at month 3. RESULTS Overall, 100 subjects received bimatoprost for eyelash hypotrichosis, 96 received onabotulinumtoxinA for glabellar lines and/or crow's feet lines, and 96 received VYC-20L for midface volume deficit. From 17 to 96 subjects received HYC-24L and/or HYC-24L+ for nasolabial folds, oral commissures, marionette lines, perioral lines, or radial cheek lines. Injections of filler generally progressed from cranial to caudal, with midface injected first. Investigator-reported factors that may have contributed to the potential benefits of this approach include the critical role of the midface in facial aesthetics, use of lower volumes of filler in individual facial areas, and anesthetic effects. CONCLUSION The investigators' perspectives and experience with the injection pattern, sequencing, volumes, and techniques may provide valuable guidance for a multimodal approach to facial aesthetic treatment.
Early infarct FLAIR hyperintensity is associated with increased hemorrhagic transformation after thrombolysis

Absence of FLAIR hyperintensity within an acute infarct is associated with stroke onset <4.5 h. However, some patients rapidly develop FLAIR hyperintensity within this timeframe. We hypothesized that development of early infarct FLAIR hyperintensity would predict hemorrhagic transformation (HT) in patients treated with tissue plasminogen activator (tPA) < 4.5 h after onset.
Psychological and physiological evaluation of emotional effects of a perfume in menopausal women

In the present study, we familiarized menopausal women with a pleasant smell in the skin care products, they used for 1 week and assessed whether their mood and emotions improved using behavioural and physiological tools. Eventually, we studied the effects of inhaling the familiar fragrance on physiological response of the subjects. An anhedonia questionnaire was used to distinguish the effects of the test products according to low vs. high score of anhedonia. Familiarization with the fragrance induced a modification of some physiological parameters, reflecting a relaxing effect, and these unconscious effects paralleled the conscious positive effects on mood recorded during the familiarization phase; it appeared that the effects were more prominent in subjects with higher scores of anhedonia.
Perceived consequences of hazing exposure during the first year of college: Associations with childhood victimization

Abstract Objective: This study investigates the association between histories of childhood victimization and perceived consequences of college hazing. Participants: First-year college students at four US universities (N = 120). Method: Participants completed Web-based surveys asking about childhood victimization (eg, child maltreatment), peer victimization, and perceived consequences of hazing during college. Results: Results indicated that college students with childhood victimization histories perceived hazing to be negative. In particular, physical dating violence and a greater total number of childhood victimization exposures were related to a higher number of perceived negative consequences. Conclusion: Past victimization exposures confer risk on college students who experience hazing, in that these students are more likely to perceive negative consequences of hazing. Hazing-related policies and outreach efforts should consider these potential negative consequences, and counselors should be aware of the link between past victimization and how hazing might be experienced.
The Religious Life During Suicide Bereavement: A Description

This exploratory study gathered narratives from 10 female suicide survivors, exploring 3 dimensions of their religious life during bereavement: (a) the function of the survivor's personal religion, (b) the function of religious support from family and friends, and (c) the function of established religious communities. Ten themes emerged from the narratives: afterlife destiny of the loved one, a more spiritual perspective, the impact on religious beliefs, support from family and friends, survivors' contribution to emotionally distant relationships, long-term and in-depth spiritual support, religious support from congregants, the ministry of clergy, the funeral service, and the return to public worship services. The participants believed that religion played an important role in their bereavement process. The results suggest future research questions, including (a) what is the perceived role of God in the suicide and the bereavement, (b) what is the relationship between the survivor's participation in a religious community and the care received from that community, and (c) what postvention do survivors wish from clergy?
Statistics notes: Measurement error

Several measurements of the same quantity on the same subject will not in general be the same. This may be because of natural variation in the subject, variation in the measurement process, or both. For example, table 1 shows four measurements of lung function in each of 20 schoolchildren (taken from a larger study1). The first child shows typical variation, having peak expiratory flow rates of 190, 220, 200, and 200 l/min. View this table: Table 1 Repeated peak expiratory flow rate (PEFR) measurements for 20 schoolchildren Let us suppose that the child has a “true” average value over all possible measurements, which is what we really want to know when we make a measurement. Repeated measurements on the same subject will vary around the true value because of measurement error. The standard deviation of repeated measurements on the same subject …
A Social Constructionist Account of Grief: Loss and the Narration of Meaning

In contrast to dominant Western conceptions of bereavement in largely intrapsychic terms, the authors argue that grief or mourning is not primarily an interior process, but rather one that is intricately social, as the bereaved commonly seek meaning in this unsought transition in not only personal and familial, but also broader community and even cultural spheres. The authors therefore advocate a social constructionist model of grieving in which the narrative processes by which meanings are found, appropriated, or assembled occur at least as fully between people as within them. In this view, mourning is a situated interpretive and communicative activity charged with establishing the meaning of the deceased's life and death, as well as the postdeath status of the bereaved within the broader community concerned with the loss. They describe this multilevel phenomenon drawing first on psychological research on individual self-narratives that organize life experience into plot structures that display some level of consistency over time, whose viability is then negotiated in the intimate interpersonal domain of family and close associates. Second, they explore public communication, including eulogies, grief accounts in popular literature, and elegies. All of these discourses construct the identity of the deceased as he or she was, and as she or he is now in the individual and communal continuing bonds with the deceased. Finally, they consider different cultural contexts to see how expressions of grief are policed to ensure their coherence with the prevailing social and political order. That is, the meanings people find through the situated interpretive and communicative activity that is grieving must either be congruent with the meanings that undergird the larger context or represent an active form of resistance against them.
Unfinished Business in Bereavement

Unfinished business (incomplete, unexpressed or unresolved relationship issues with the deceased) is frequently discussed as a risk factor for chronic and severe grief reactions. However, few empirical studies have examined this construct. The present study aimed to address this gap in the literature by examining the presence and severity of unfinished business as well as common themes of unfinished business reported in open-ended qualitative narratives among a sample of 224 bereaved individuals. In bivariate analyses, self-reported presence of unfinished business and the severity of distress due to unfinished business were both found to be associated with poorer bereavement outcomes. However, after controlling for potential confounds, distress related to unresolved issues with the deceased emerged as a more robust correlate of these outcomes. Qualitative responses were categorized, and the type of reported unfinished business was not significantly related to the degree of unfinished business distress or other bereavement outcomes. These findings provide preliminary justification for bereavement interventions that aim to ameliorate distress related to unresolved relational issues with the deceased.
The impact of practical support on parental bereavement: Reflections from a study involving parents bereaved through military death

ABSTRACT This article, drawing on data from a wider study, describes the impact that U.K. bereaved military parents ascribe to the practical support (help with home and garden maintenance) that they received following the death of their son. The type of practical support offered to parents has had a wide-ranging and significant impact on them. In addition to helping them find meaning and maintain continuing bonds, this form of support contributed to their capacity to engage in restoration-focused coping. As a symbolic resource, this type of practical support may be a significant moderator of distress in the psychosocial transition of bereavement.
Prediction of individual differences in adjustment to loss: Acceptance and valued-living as critical appraisal and coping strengths

ABSTRACT Our strengths-based model of coping with death and dying proposes acceptance and valued-living as key coping and appraisal strengths for the bereaved. These are core components of Acceptance and Commitment Therapy (ACT). The aim of this study was to provide an initial exploration of the theorized relationships via a survey of 97 bereaved university students. Using hierarchical regression analysis it was found that acceptance and valued-living were significant predictors of grief, while controlling for other model variables and loss characteristics. Results have implications for ACT-based approaches in supporting those bereaved who are struggling with their grief.
The release of DNA into the plasma of mice following hepatic cell death by apoptosis and necrosis

Abstract The goal of these investigations was to measure levels of DNA in the plasma of mice following administration of hepatotoxic agents to induce apoptotic or necrotic cell death and determine any differences in the release of this marker depending upon death pathway. For this purpose, the effects of varying doses of anti-Fas, acetaminophen (APAP) or carbon tetrachloride (CCl4) were assessed in normal mice. Plasma DNA was measured fluorometrically by the dye PicoGreen while lactate dehydrogenase (LDH) and caspase 3, other molecules released with cell injury or death, were measured by enzymatic assays. Histology was used to assess the occurrence of apoptosis or necrosis. Results of these experiments indicate that increased blood DNA levels occurred with all three agents and were highest with anti-Fas and CCl4; caspase 3 levels were much higher with anti-Fas than the other agents. Histological examination confirmed the predominance of apoptotic death with anti-Fas and necrotic death with APAP and CCl4. These results indicate that increased blood DNA is common in hepatotoxic injury and is a feature of both apoptotic and necrotic death.
Meaning making after a near-death experience: The relevance of intrapsychic and interpersonal dynamics

ABSTRACT This study aims to investigate the processes used by individuals to integrate a near-death experience (NDE) and to discuss the use of a meaning-making component to help people who have had such experiences. A psychotherapist interviewed six individuals who reported having had a NDE. Transcripts of the interviews were coded using an interpretative phenomenological analysis. The authors identified intrapsychic and interpersonal dynamics implicated in the individuals’ meaning-making processes, and the problems encountered during their integration of the experience. Meaning-based approaches are a feasible theoretical framework for shedding light on the NDE and providing support for people who have lived through them.
Informal care networks’ views of palliative care services: Help or hindrance?

ABSTRACT Most people indicate their preference to die at home; however, in the developed world, most die in hospital. Dying at home requires complex factors to be in place in health services and informal networks of care to successfully provide support. This study examines the ways health systems, services, and individual health care professionals influence care at home at the end of life. Three principles guide the reorientation of health services and enable their transition from hindrance to help: re-evaluation of organizational values, recognition of the primacy of caring networks, and realignment of the inherent paternalism in health care provision.
Arsenic and Lung Disease Mortality in Bangladeshi Adults

Background: Chronic arsenic exposure through drinking water is a public health problem affecting millions of people worldwide, including at least 30 million in Bangladesh. We prospectively investigated the associations of arsenic exposure and arsenical skin lesion status with lung disease mortality in Bangladeshi adults. Methods: Data were collected from a population-based sample of 26,043 adults, with an average of 8.5 years of follow-up (220,157 total person-years). There were 156 nonmalignant lung disease deaths and 90 lung cancer deaths ascertained through October 2013. We used Cox proportional hazards models to estimate adjusted hazard ratios and 95% confidence intervals (CIs) for lung disease mortality. Results: Creatinine-adjusted urinary total arsenic was associated with nonmalignant lung disease mortality, with persons in the highest tertile of exposure having a 75% increased risk for mortality (95% CI = 1.15–2.66) compared with those in the lowest tertile of exposure. Persons with arsenical skin lesions were at increased risk of lung cancer mortality (hazard ratio = 4.53 [95% CI = 2.82–7.29]) compared with those without skin lesions. Conclusions: This prospective investigation of lung disease mortality, using individual-level arsenic measures and skin lesion status, confirms a deleterious effect of ingested arsenic on mortality from lung disease. Further investigations should evaluate effects on the incidence of specific lung diseases, more fully characterize dose-response, and evaluate screening and biomedical interventions to prevent premature death among arsenic-exposed populations, particularly among those who may be most susceptible to arsenic toxicity.
Performative retelling: Healing community stories of loss through Playback Theatre

ABSTRACT Restorative retelling (RR) is an evidence-based procedure for facilitating adaptation following traumatic bereavement. In this paper, we introduce performative retelling (PR), a variation on RR, which fosters healing from personal losses and portrays personal reactions to collective tragedy. We describe our collaboration with an ex-offender reentry program, the Memphis Police Department, and Playback Theatre to use improvisational community theatre to bridge the gap between law enforcement and the citizens they serve. We review program outcomes to-date and illustrate its impact using participant stories. We argue that training police and citizens in PR can potentially transform broken narratives of police-community relations.
Stabilisation of a highly reactive bis(mu-oxo)dicopper(III) species at room temperature by electronic and steric constraint of an unconventional nitrogen donor ligand.

Herein we present an innovative combination of EXAFSspectroscopy and resonant Raman scattering for the charac-terisation of the ground state and structural dynamics of athermally stable binuclear bisACHTUNGRE(m-oxo) dicopperACHTUNGRE(III) species.Peralkylated bis(guanidine)-based ligands are used in thesynthesis of this compound.
Liver fat accumulation is associated with circulating PCSK9

Abstract Background: Nonalcoholic fatty liver disease (NAFLD) associates with cardiovascular disease independently of classic risk factors. Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) is secreted by hepatocytes and inhibits the uptake of low-density lipoproteins by targeting the receptor for degradation, and possibly lipogenesis. PCSK9 loss-of-function mutations and anti-PCKS9 drugs reduce LDL-cholesterol. Aim: To evaluate whether hepatic fat content is associated with circulating PCSK9. Materials and methods: In 201 consecutive patients biopsied for suspected nonalcoholic steatohepatitis, liver damage was quantified by NAFLD activity score, circulating PCSK9 by ELISA, and hepatic mRNA by qRT-PCR in a subset (n = 76). Results: Circulating PCSK9 was associated with steatosis grade (p = 0.0011), necroinflammation (p < 0.001), ballooning (p = 0.005), and fibrosis stage (p = 0.001). At multivariate analysis, PCSK9 was associated with steatosis grade (p = 0.012), older age and lower BMI, independently of sex, hyperglycemia, and fibrosis/inflammation. Circulating PCSK9 was associated with hepatic expression of SREBP-1c (p = 0.0002) and FAS (p = 0.03). PCSK9 mRNA levels were also correlated with steatosis severity (p = 0.04) and hepatic APOB (p < 0.001), SREBP-1c (p = 0.047) and FAS expression (p = 0.001). Conclusions: Circulating PCSK9 increases with hepatic fat accumulation and correlates with the severity of steatosis, independently of metabolic confounders and liver damage. Modulation of PCSK9 synthesis and release might be involved in NAFLD pathogenesis. Key Messages Circulating PCSK9 levels increase with hepatic fat accumulation. Circulating PCSK9 levels are associated with increased de novo lipogenesis. Hepatic PCSK9 expression is associated with steatosis severity and activation of lipogenesis.