Miracle-dz/UniFAR-FTUs huggingface dataset:
Cost-effectiveness of accelerated perioperative care and rehabilitation after total hip and knee arthroplasty.

BACKGROUND Accelerated perioperative rehabilitation protocols following total hip and knee arthroplasties are currently being implemented worldwide, but the cost-effectiveness of these protocols from a societal perspective is not known. We compared the cost-effectiveness of an accelerated perioperative care and rehabilitation protocol with that of a more standard protocol for patients treated with total hip and knee arthroplasty. METHODS A cost-effectiveness study was undertaken as a study piggybacked on a randomized clinical trial comparing early outcomes of an accelerated and intensive postoperative rehabilitation regimen with those of a more standard rehabilitation protocol. We assessed eighty-seven patients (forty-two who received the standard protocol and forty-five who received the accelerated protocol) for a total of twelve months. Costs from the time of the patient's visit immediately before the operation to one year postoperatively were calculated with use of activity-based costing analysis. Postoperative quality-adjusted life-years (QALYs) were calculated from validated patient diaries and questionnaires at fifteen time points. The primary objective was to determine whether one intervention was dominant over the other during a twelve-month period or, if neither was dominant, to determine the incremental cost-effectiveness ratio. RESULTS The result of the randomized clinical trial showed the accelerated intervention to be effective, with a reduction in the length of the hospital stay and a gain in health-related quality of life at the three-month follow-up time point. The cost-effectiveness study showed the accelerated protocol to be significantly less expensive than the standard protocol (p=0.036), with an average reduction in cost of 18,880 Danish kroner (95% confidence interval, 1899 to 38,152) (approximately US $4000). Patients treated with the accelerated protocol following hip arthroplasty had an additional average gain of 0.08 QALY (95% confidence interval, 0.02 to 0.15) compared with the patients who received the standard protocol (p=0.006); this led to a 98% dominance of the accelerated protocol over the standard protocol. No significant or clinically relevant difference in the numbers of QALYs associated with the two protocols was observed for the patients treated with knee arthroplasty. CONCLUSIONS An accelerated perioperative care and rehabilitation protocol can be both cost-saving and clinically more effective after total hip arthroplasty, whereas it can be cost-saving with no observed significant difference in effect, from a societal perspective, after knee arthroplasty.
Miranda cargo‐binding domain forms an elongated coiled‐coil homodimer in solution: Implications for asymmetric cell division in Drosophila

Miranda is a multidomain adaptor protein involved in neuroblast asymmetric division in Drosophila melanogaster. The central domain of Miranda is necessary for cargo binding of the neural transcription factor Prospero, the Prospero‐mRNA carrier Staufen, and the tumor suppressor Brat. Here, we report the first solution structure of Miranda central “cargo‐binding” domain (residues 460–660) using small‐angle X‐ray scattering. Ab initio modeling of the scattering data yields an elongated “rod‐like” molecule with a maximum linear dimension (Dmax) of ∼22 nm. Moreover, circular dichroism and cross‐linking experiments indicate that the cargo‐binding domain is predominantly helical and forms a parallel coiled‐coil homodimer in solution. Based on the results, we modeled the full‐length Miranda protein as a double‐headed, double‐tailed homodimer with a long central coiled‐coil region. We discuss the cargo‐binding capacity of the central domain and propose a structure‐based mechanism for cargo release and timely degradation of Miranda in developing neuroblasts.
A randomized trial of a DWI intervention program for first offenders: intervention outcomes and interactions with antisocial personality disorder among a primarily American-Indian sample.

BACKGROUND Randomized trial evidence on the effectiveness of incarceration and treatment of first-time driving while intoxicated (DWI) offenders who are primarily American Indian has yet to be reported in the literature on DWI prevention. Further, research has confirmed the association of antisocial personality disorder (ASPD) with problems with alcohol including DWI. METHODS A randomized clinical trial was conducted, in conjunction with 28 days of incarceration, of a treatment program incorporating motivational interviewing principles for first-time DWI offenders. The sample of 305 offenders including 52 diagnosed as ASPD by the Diagnostic Interview Schedule were assessed before assignment to conditions and at 6, 12, and 24 months after discharge. Self-reported frequency of drinking and driving as well as various measures of drinking over the preceding 90 days were available at all assessments for 244 participants. Further, DWI rearrest data for 274 participants were available for analysis. RESULTS Participants randomized to receive the first offender incarceration and treatment program reported greater reductions in alcohol consumption from baseline levels when compared with participants who were only incarcerated. Antisocial personality disorder participants reported heavier and more frequent drinking but showed significantly greater declines in drinking from intake to posttreatment assessments. Further, the treatment resulted in larger effects relative to the control on ASPD than non-ASPD participants. CONCLUSIONS Nonconfrontational treatment may significantly enhance outcomes for DWI offenders with ASPD when delivered in an incarcerated setting, and in the present study, such effects were found in a primarily American-Indian sample.
Choosing Fusion Levels in Progressive Thoracic Idiopathic Scoliosis

The selection of fusion levels in thoracic idiopathic scoliosis was subjected to multicenter retrospective review to test the validity of the classification system and recommendations of King et al. The 253 patients reviewed were treated by posterior fusion and Harrington instrumentation. Bending films were of little help in selecting fusion levels. Standing radiographs alone were usually adequate. King Type II curves may yield better lumbar correction if the lumbar curve is partially included in the fusion. Type IV curves may be safely fused one level proximal to the stable vertebrae.
Echoplanar BOLD fMRI of brain activation induced by concurrent transcranial magnetic stimulation.

RATIONALE AND OBJECTIVES The authors demonstrate the feasibility of combining transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI) inside an MR scanner to noninvasively stimulate and image regional brain activity. METHODS Echoplanar blood oxygen level dependent (BOLD)-based fMRI studies of TMS response were performed on three human volunteers inside a standard 1.5 T MR scanner using independent computer control to interleave echoplanar image acquisition and stimulation of right thumb primary motor cortex with a nonferromagnetic TMS coil. RESULTS Significant (P< 0.001) response was observed in motor cortex under the TMS coil during stimulation compared to rest, as well in auditory cortex, the latter presumably due to the loud "snap" when the coil was pulsed. CONCLUSIONS Concurrent TMS stimulation and echoplanar BOLD fMRI imaging is possible. This method has potential for tracing neural circuits with brain imaging, as well as investigating the effects of TMS.
Identification of the Major Synaptojanin-binding Proteins in Brain*

Synaptojanin is a nerve-terminal enriched inositol 5-phosphatase thought to function in synaptic vesicle endocytosis, in part through interactions with the Src homology 3 domain of amphiphysin. We have used synaptojanin purified from Sf9 cells after baculovirus mediated expression in overlay assays to identify two major synaptojanin-binding proteins in rat brain. The first, at 125 kDa, is amphiphysin. The second, at 40 kDa, is the major synaptojanin-binding protein detected, is highly enriched in brain, is concentrated in a soluble synaptic fraction, and co-immunoprecipitates with synaptojanin. The 40-kDa protein does not bind to a synaptojanin construct lacking the proline-rich C terminus, suggesting that its interaction with synaptojanin is mediated through an Src homology 3 domain. The 40-kDa synaptojanin-binding protein was partially purified from rat brain cytosol through a three-step procedure involving ammonium sulfate precipitation, sucrose density gradient centrifugation, and DEAE ion-exchange chromatography. Peptide sequence analysis identified the 40-kDa protein as SH3P4, a member of a novel family of Src homology 3 domain-containing proteins. These data suggest an important role for SH3P4 in synaptic vesicle endocytosis.
Human multimedia display interface based on human activity recognition

In this paper, we will propose a Human Multimedia Display Interface. The interface uses the tracking of human hand movements to control the IP-TV. This paper presents an improved CAMSHIFT algorithm to control an IP-TV system. The CAMSHIFT algorithm (Continuously Adaptive MeanShift) is a method of using color information[1]. It can do tracking with a specific color of the target. In some typical environmental constraints, it can obtain good tracking performance. However, as the question of noise, large area similar to the color interference and so on, only by CAM-SHIFT algorithm it is not competent. Against these issues we propose an improved CAMSHIFT algorithm[2].
Anatomy of the Intrinsic Hand Muscles Revisited: Part I. Interossei

&NA; In this article, the anatomic variations in interosseous muscle insertions are described based on a review of the literature and 14 fresh cadaver hand dissections. The findings are correlated and compared with those of a number of other investigators, and the clinical implications are discussed (i.e., in the correction of ulnar deviation in arthritis patients and in the treatment of congenital anomalies of the hand). It is concluded that descriptions of insertion sites of the intrinsic muscles have been oversimplified by previous researchers, and a number of variations are identified through the cadaver dissections. The differing and confusing nomenclature used by other investigators is discussed and simplified. The results of this study indicate that not only are there important distal insertions onto bone and the extensor apparatus, but there is also an additional insertion onto the volar plate (“assemblage nucleus”), as Zancolli reported. It was found that the palmar interossei, generally thought to insert only onto the extensor apparatus, could also insert onto bone and onto the volar plate. Classic teaching is that all dorsal interossei (except the third) have two heads and that all palmar interossei have only one head. In this study, however, 38 percent of the palmar interossei and 75 percent of the dorsal interossei had more than one head. The complexity of the interossei is apparent when as many as three different muscle heads are present, each with a different distal destination. (Plast. Reconstr. Surg. 110: 1211, 2002.)
VISA International：混序组织的机理与特征研究

VIS AInternational创造了一种把组织学习、知识管理与复杂性理论融为一体的智慧型组织，是一个具有自组织功能的组织新范式，在“混沌”和“有序”之间达到了一种平衡，产生了竞争与合作相互协调的机制，使组织呈现出既有适应力又有创新力的特点；VIS AInternational体现了信息化、知识化组织的核心本质，非常值得中国企业借鉴。
Role of fibrinolytic and clotting parameters in the diagnosis of liver veno-occlusive disease after hematopoietic stem cell transplantation in a pediatric population

Summary Hepatic veno-occlusive disease (VOD) is a severe complication after hematopoietic stem cell transplantation (HSCT). Recent studies, mainly in adults receiving HSCT, have identified an increase in the plasminogen activator inhibitor-1 (PAI-1) as a possible marker of VOD. To confirm this finding, the fibrinolytic, coagulation and liver function parameters were assayed before and weekly for 1 month after 61 HSCT performed in 53 consecutive children. Non-VOD patients had a slight increase in t-PA antigen, fibrinogen and P-selectin levels, as well as a mildly longer aPTT and a drop in antithrombin after HSCT. The 6 children with VOD (9.84%) had an early and significant increase in PAI-1 antigen and activity (p< 0.0001), t-PA antigen (p< 0.0001) and D-dimer (p< 0.01) levels, and a decrease in plasminogen, α2-antiplasmin and PT emerged 2(±1) days before the clinical diagnosis of VOD by comparison with mean post-HSCT values in the non-VOD patients. Significant differences were also detected for these parameters and antithrombin levels between non-VOD and VOD patients soon after the clinical onset of VOD, whereas the rise in bilirubin levels became significant only later on. In conclusion, variations in fibrinolytic test findings after HSCT, and PAI-1 in particular, may facilitate the early diagnosis of VOD in pediatric patients after HSCT.
Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis.

PURPOSE The epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small-cell lung carcinoma (NSCLC), and EGFR inhibitors are promising new therapeutic agents. The molecular mechanisms responsible for EGFR overexpression are poorly understood. MATERIALS AND METHODS Gene copy number and protein status of EGFR were investigated in microarrayed tumors from 183 NSCLC patients, including squamous cell carcinoma (SCC; 89 patients) and non-SCC (94 patients) histologies. Protein expression was assessed by immunohistochemistry on a scale from 0 to 400 (percentage of positive cells x staining intensity). Gene and chromosome 7 copy numbers were identified by fluorescent in situ hybridization (FISH). RESULTS EGFR protein overexpression was observed in 62% of the NSCLC (25% scored 201 to 300; 37% scored 301 to 400), more frequently in SCC than non-SCC (82% v 44%; P <.001), and in 80% of the bronchioloalveolar carcinomas. The prevalent FISH patterns were balanced disomy (40%) and trisomy (38%) for EGFR gene and chromosome 7 (40%), whereas balanced polysomy was seen in 13% and gene amplification was seen in 9% of the patients. Gene copy number correlated with protein expression (r = 0.4; P <.001). EGFR overexpression or high gene copy numbers had no significant influence on prognosis. CONCLUSION EGFR overexpression is frequent in NSCLC, is most prominent in SCC, and correlates with increased gene copy number per cell. High gene copy numbers per cell showed a trend toward poor prognosis. It will be important to evaluate EGFR gene and EGFR protein status and signal protein expression to properly interpret future clinical trials using EGFR inhibitors.
Keystroke Dynamics Authentication with Project Management System

Generally user authentication is done using username and password that is called as login process. This login process is not more secure because, however a login session is still unprotected to impersonator when the user leaves his computer without logging off. Keystroke dynamics methods can be made useful to verify a user by extracting some typing features then, after the authentication process has successfully ended. From the last decade several studies proposed the use of keystroke dynamics as a behavioral biometric tool to verify users. We propose a new method, for representing the keystroke patterns by joining similar pairs of consecutive keystrokes. The above proposed method is used to consider clustering the di-graphs which are based on their temporal features. In this project, authentication system is provide to project management system that make more Secure management system without acknowledging unauthorized user. The Project Management System addresses the management of software projects. It provides the framework for organizing and managing resources in such a way that these resources deliver all the work required to complete a software project within defined scope, time and cost constraints. The system applies only to the management of software projects and is a tool that facilitates decision making.
Human papillomavirus infections in women with clinical gynaecological diseases in southwest China

The aim of this study was to determine the prevalence of human papillomavirus (HPV) infections in women with different gynaecological diseases (GDs) and ages in southwest China. With the assay of reverse dot blot, a total of 5544 cervical samples, including 1008 normal and 4536 abnormal specimens from women with GDs, were assayed for HPV detection. For the normal group, 20.2% (204/1008) tested positive for HPV, of which 40.2% (82/204) were high-risk (HR-HPV) genotypes. In the 4536 abnormal samples, 1569 women (34.6%) tested positive for HPV: 73.5% (1153/1569) had a single infection, 17.7% (277/1569) dual infection and 8.8% (138/1569) multiple HPV infection. Of 1569 HPV-positive specimens, 58.7% (921/1569) were infected with only HR-HPV genotypes. Significant differences in HPV infections were found among women of different ages (P < 0.01), number of pregnancies (P < 0.01), GDs (P < 0.01) and age at first sex (P < 0.01). In the present study, we found a high prevalence of HPV infection in women with GDs in southwest China. In addition to HPV types 16 and 18, a significant proportion of other HR-HPV genotypes were detected in this population.
Pilot-based assessment of the economics of recycling construction demolition waste

The significant amount of waste generated from construction demolition has become a chronic problem in many developing countries. Using data obtained from demolition contractors and various other sources, this paper proposes a framework for proper handling of construction demolition waste (CDW) to serve as a decision support tool in countries suffering from the lack of national CDW management guidelines. The framework is then demonstrated through a case study in the city of Beirut, Lebanon, and a sensitivity analysis is carried out to examine the economic feasibility of developing a recycling facility. The analysis showed that in order for a facility to be feasible, a gate fee should be charged in the presence of a market for recycled aggregates. The results confirm the significance of instigating and implementing legislation to control illegal dumping, constructing, and managing engineered landfills, and establishing markets for recycled CDW.
Compact Low-Profile Dual-Band Patch Antenna Using Novel TL-MTM Structures

A low-profile, single-feed, single-layered dual-band patch antenna using mushroom-like transmission-line metamaterial (TL-MTM) structures is proposed in this letter. The characteristics of the new proposed TL-MTM structure are initially studied in detail by circuit analysis and HFSS simulation, and the working mechanism and radiation performances of the antenna are examined and illustrated for the two operating bands, respectively. The proposed antenna occupies an overall size of 0.22λg×0.22 λg×0. 042λg. Measured results exhibit that the fabricated antenna has a monopole-like radiation pattern with an efficiency of 79.4% at 2.76 GHz, and a patch-like radiation pattern with an efficiency of 90.8% at 5.23 GHz.
Neurotransmitters and neuromodulators of the mammalian cochlea.

Major topics addressed in this review on neurotransmitters and neuromodulators of the mammalian cochlea are ; 2) neuronal circuity of the organ of Corti ; 2) hair cell neurotransmitter(s) ; efferent neurotransmitters and neuromodulators (acetylcholine, γ-aminobutyric acid, dopamine, enkephalins, dynorphins, calcitonin gene-related peptide, excitatory amino acids ; and 3) other neuroactive substances in the cochlea (adenosine, ATP, taurine, auditory nerve-activating substance, histamine)
Common and rare variants of the THBS1 gene associated with the risk for autism

Objectives Autism is a severe neurodevelopmental disorder. Many susceptible or causative genes have been identified, and most of them are related to synaptogenesis. The THBS1 gene encodes thrombospondin 1, which plays a critical role in synaptogenesis of the central nervous system in the developing brain. However, no study has been carried out revealing that THBS1 is an autism risk gene. Methods We analyzed the whole coding region and the 5′-untranslated region of the THBS1 gene in 313 autistic patients by Sanger sequencing, which was also used to analyze the identified variants in 350 normal controls. Association analysis was carried out using PLINK or R. Haplotype analysis was carried out using Haploview. Functional prediction and conservation analysis of missense variants were carried out using ANNOVAR. Results Twelve variants, including five common variants and seven rare variants, were identified in the THBS1 coding region and the 5′-untranslated region. Among them, one common variant (c.1567A>G:p.T523A) was significantly associated with autism (P<0.05). Two rare variants (c.2429G>A:p.R810Q, c.3496G>C:p.E1166Q) were absent in the 350 controls and were not reported in the single nucleotide polymorphism database (dbSNP). Combined association analysis of the rare variants (minor allele frequency<0.01) in patients and Asian samples in the 1000 genome project revealed a significant association between these rare variants and autism (P=0.039). Conclusion Our data revealed that both common and rare variants of the THBS1 gene are associated with risk for autism, suggesting that THBS1 is a novel susceptible gene for autism.
Model-based event-triggered quantized control for linear discrete-time systems

We discusses the stabilization problem for networked linear discrete system using quantized state in this paper. Firstly, a event-triggered control policy is proposed based on the quantized state of the system model. Then, by using linear matrix inequality method, a new co-design algorithm for the parameter of event-triggered mechanism and state feedback controller is presented. In addition, based on Bernoulli binary distribution model, a mean square asymptotical stability condition is proposed for the obtained controller when there exits packet dropout phenomenon. Finally, the effectiveness of the proposed approach is shown by some numerical simulations.
Wideband speech coding using ADPCM and a new spectral replication method based on parametric stereo coding

A spectral replication coding scheme based on parametric stereo is introduced in this paper. Parametric stereo technique was initiated to encode both the left and right stereo channels more efficiently by extracting redundancy between these channels. A mono downmix signal plus small side information (some parameters) are transmitted instead of two channels. In the decoder both channels are reconstructed from the mono downmix signal and the received parameters. We have borrowed this technique to create a new spectral replication coding. In the proposed method, the signal is divided into two low and high frequency parts. We deal, then, with these parts as left and right channels in the stereo signal to acquire the parameters where the low part signal plays the role of the downmix signal which is coded using ADPCM technique. The results show that we can achieve 16.6–21.5% reduction in bit rate, in comparison with G.722 standard, bearing little degradation in quality.