Miracle-dz/UniFAR-FTUs huggingface dataset:
DMM019000 1093..1103

Hypoxia-inducible factor 1α (HIF1α) is a transcription factor that regulates the adaptation of cells to hypoxic microenvironments, for example inside solid tumours. Stabilisation of HIF1α can also occur in normoxic conditions in inflamed tissue or as a result of inactivating mutations in negative regulators of HIF1α. Aberrant overexpression of HIF1α in many different cancers has led to intensive efforts to develop HIF1α-targeted therapies. However, the role of HIF1α is still poorly understood in chronic inflammation that predisposes the colon to carcinogenesis. We have previously reported that the transcription of HIF1α is upregulated and that the protein is stabilised in inflammatory lesions that are caused by the non-steroidal anti-inflammatory drug (NSAID) sulindac in the mouse proximal colon. Here, we exploited this side effect of long-term sulindac administration to analyse the role of HIF1α in colon inflammation using mice with a Villin-Cre-induced deletion of Hif1α exon 2 in the intestinal epithelium (Hif1α). We also analysed the effect of sulindac sulfide on the aryl hydrocarbon receptor (AHR) pathway in vitro in colon cancer cells. Most sulindac-treated mice developed visible lesions, resembling the appearance of flat adenomas in the human colon, surrounded by macroscopically normal mucosa. Hif1α mice still developed lesions but they were smaller than in the Hif1α-floxed siblings (Hif1α). Microscopically, Hif1α mice had significantly less severe colon inflammation than Hif1α mice. Molecular analysis showed reduced MIF expression and increased E-cadherin mRNA expression in the colon of sulindac-treated Hif1α mice. However, immunohistochemistry analysis revealed a defect of E-cadherin protein expression in sulindac-treated Hif1α mice. Sulindac sulfide treatment in vitro upregulated Hif1α, c-JUN and IL8 expression through the AHR pathway. Taken together, HIF1α expression augments inflammation in the proximal colon of sulindac-treated mice, and AHR activation by sulindac might lead to the reduction of E-cadherin protein levels through the mitogen-activated protein kinase (MAPK) pathway.
Assessment and selection of multi-trait plant growth promoting bacteria associated with rice rhizosphere

The application of plant growth promoting bacteria is the need of present day for sustainable agriculture. The present study was carried out to assess and select of multi-trait plant growth promoting bacteria associated with rice. Seventeen rhizospheric samples from different rice varieties were collected from different locations of South Gujarat. Total of 98 isolates obtained from different rhizospheric samples were screened out for PGPR activities. Primary screening revealed 15 isolates having potential PGPR activities. These isolates were further evaluated for their ability to produce IAA, phosphate solubilization, siderophore production, protease, cellulase and chitinase enzyme production quantitatively. The result showed that isolate M2 found to produce maximum of 48.4 mg/L IAA, 80 % siderophore and solubilizing 11 mg/L phosphate. Besides these growth promotion traits, M2 also found to produce 14 IU protease, 0.98 IU cellulase and 0.24 IU chitinase. Considering the multi-trait plant growth promotion abilities of M2 isolate it was further characterized and identified tentatively as Pseudomonas species.
The Never-Ending Story Teller – A Narratological Genealogy of Storytelling in Marketing and Management

Storytelling has become remarkably important in marketing and in numerous other areas in the discipline of management and organization studies. While recent studies have only focussed on details, narratological theories, unlike other popular approaches, offer the chance to observe storytelling from a structuralist or functionalist view as a systematic phenomenon that follows specific rules. These basic rules can be combined in a step-by-step blueprint that permits the creation and advancement of stories that pertain to the needs of marketing and management. In this research, the most important aspects of narrative theory have been compiled, from literature and language studies of the post pragmatic turn with modern ideas regarding screenwriting, archetypal characters, and brand management. The results reflect the need to develop a concept that can detect major problems with coherent storytelling. While storytelling has become of major interest in marketing and management, the phenomenon has not been sufficiently discussed from the perspective of narrative theory, the field in which it is originally rooted. Hence, many specific story elements have not been examined. This article collects the most important approaches to framework stories and consequently presents the possibility of creating a concept of storytelling based on narrative elements, with both contributions to further research and practical implications.
Molecular DNA identity of the mouflon of Cyprus (Ovis orientalis ophion, Bovidae): Near Eastern origin and divergence from Western Mediterranean conspecific populations

The mouflon population of Cyprus (Ovis orientalis ophion) comprises historically preserved feral descendants of sheep domesticated during the Neolithic. We determined genetic identity of this taxon in order to elucidate its systematic placement and enforce its protection. We used 12 loci of microsatellite DNA to infer genetic relationships between the Cypriot mouflon and either long-time isolated (Corsica, Sardinia) or recently introduced (central Italy) European mouflons (O. o. musimon). We also sequenced the mitochondrial DNA (mtDNA) Cytochrome-b gene to infer the origin of the Cypriot mouflon including many National Centre for Biotechnology Information (NCBI) entries of European and Near Eastern conspecifics. Microsatellites disclosed net divergence between Western Mediterranean and Cypriot mouflon. The latter was included in the highly heterogeneous Near Eastern O. orientalis mtDNA group, Iran representing the most credited region as the source for its ancient introduction to Cyprus. Both international and national legislation protect the mouflon of Cyprus as a wild taxon (O. o. ophion). However, the IUCN Red List of Threatened Species and NCBI include the Cypriot mouflon as subspecies of its respective domestic species, the sheep (O. aries). Unfortunately, people charged with crime against protected mouflon may benefit from such taxonomic inconsistency between legislation and databases, as the latter can frustrate molecular DNA forensic outcomes. Until a definitive light can be shed on Near Eastern O. orientalis systematics, we suggest that the Cypriot mouflon should be unvaryingly referred to as O. o. ophion in order not to impair conservation in the country where it resides.
Cross-Cultural Psychology Bulletin December 2004

14 There is an old Chinese saying that “a journey of a thousand miles begins with a single step. ” The destination of this particular journey turned out to be, appropriately enough, in the Chinese city of Xi’an. This is where Judit Arends-Toth and I jointly received the Harry and Pola Triandis Dissertation Award presented at the XVIIth Congress of the IACCP. They say that the journey is always more important than the destination, but I never imagined that there would be such an honor at this journey’s end. Just when did I take the first step?
AN ERROR ANALYSIS METHOD SPP–BEAM AND A CONSTRUCTION GUIDELINE OF NONCONFORMING FINITE ELEMENTS FOR FOURTH ORDER ELLIPTIC PROBLEMS

Abstract Under two hypotheses of nonconforming finite elements of fourth order elliptic problems, we present a side–patchwise projection based error analysis method (SPP–BEAM for short). Such a method is able to avoid both the regularity condition of exact solutions in the classical error analysis method and the complicated bubble function technique in the recent medius error analysis method. In addition, it is universal enough to admit generalizations. Then, we propose a sufficient condition for these hypotheses by imposing a set of in some sense necessary degrees of freedom of the shape function spaces. As an application, we use the theory to design a P3 second order triangular H 2 non-conforming element by enriching two P4 bubble functions and, another P4 second order triangular H nonconforming finite element, and a P3 second order tetrahedral H 2 non-conforming element by enriching eight P4 bubble functions, adding some more degrees of freedom.
Multiomics approach unravels fertility transition in a pigeonpea line for a two‐line hybrid system

Pigeonpea [Cajanus cajan (L.) Millsp. ] is a pulse crop cultivated in the semi‐arid regions of Asia and Africa. It is a rich source of protein and capable of alleviating malnutrition, improving soil health and the livelihoods of small‐holder farmers. Hybrid breeding has provided remarkable improvements for pigeonpea productivity, but owing to a tedious and costly seed production system, an alternative two‐line hybrid technology is being explored. In this regard, an environment‐sensitive male sterile line has been characterized as a thermosensitive male sterile line in pigeonpea precisely responding to day temperature. The male sterile and fertile anthers from five developmental stages were studied by integrating transcriptomics, proteomics and metabolomics supported by precise phenotyping and scanning electron microscopic study. Spatio‐temporal analysis of anther transcriptome and proteome revealed 17 repressed DEGs/DEPs in sterile anthers that play a critical role in normal cell wall morphogenesis and tapetal cell development. The male fertility to sterility transition was mainly due to a perturbation in auxin homeostasis, leading to impaired cell wall modification and sugar transport. Limited nutrient utilization thus leads to microspore starvation in response to moderately elevated day temperature which could be restored with auxin‐treatment in the male sterile line. Our findings outline a molecular mechanism that underpins fertility transition responses thereby providing a process‐oriented two‐line hybrid breeding framework for pigeonpea.
oblematic mobile phone use among adolescents with mild intellectual disability*

This study was conducted with the aim to determine the frequency and predictors of problematic mobile phone use in adolescents with mild intellectual disability (MID) and typically developing adolescents (TDA). The sample included 623 TDA and 67 adolescents with MID. The Mobile Phone Problem Use Scale, Loneliness and Social Dissatisfaction Scale, and Rosenberg Self-Esteem Scale were used as primary outcome measures. The percentage of MID and TDA participants with problematic mobile phone use was 11.9% and 9.8% respectively, but there were twice as many participants who belong to the risk group among the participants with MID (20.9%) than among TDA ones (10.2%). Problematic use of mobile phones was related to the number of years of mobile phone usage, more frequent use, female gender, younger age, as well as with a lower level of self-esteem, and a higher level of loneliness. This study showed that almost every third adolescent with MID is having problematic or risky mobile phone use.
Age Related Cognitive Impairment and Physical Disability to Measure Quality of Life (QoL) Using PSCQL-MT Tool in the Senior Citizens of Lahore, Pakistan

The impact of physical exercise activity and cognitive executive functions and their impact on the QoL is of great importance in performing ADL and IADL in the senior citizens. This study will provide an inside into multidimensional factors which can impact the cognitive and physical mobility of the persons in the old age. Moreover, it is also desirable to measure the QoL on the basis of PSCQL-MT on a larger scale for longer duration of time. The role of gender on the QoL using different variables needs to be further evaluated. The objectives of the study are: To find out the relationship between the cognitive improvement due to physical exercise activities in the elderly persons. To find out the effect of different variables on QoL in male and female. The following hypothesis will be tested based on PSCQL-MT questionnaire. H1: Physical exercise activities play an important role in stabilizing or improving the cognitive functions on the basis of gender in the study population. H2: Physical exercise activities do not play an important role in stabilizing or improving the cognitive functions on the basis of gender in the study population. The result of the study showed that recent physical exercise activity does not play any significant role in improving the QoL. The cognitive functions in the senior citizens who perform ADL and IADL depend upon the physical mobility and mental ability for the persons. The long term physical exercise activity, socio-cultural level, lifestyle, leisure activities and health behavior play a significant in maintaining the cognitive functions and physical health in the senior citizens. The scope of this study was to find out the moderating factors which can preserve cognitive executive functions in the senior citizens. Our study is more related on the concept of physical exercise activities and its impact on the cognitive executive functions in the elderly. The PSCQL-MT questionnaire contains all the dimensions which are necessary to find out the relationship of physical activities and cognitive functions in terms of ADL and IADL. The PSCQL-MT questionnaire and the modified questionnaires are very closed in terms of their dimensions. We concluded from the study that physical exercise activity in the long term is very important in preserving the cognitive functions in the elderly persons. We also found out that the PSCQL-MT questionnaire is a good addition to conduct research on the different aspects of healthy living in the different population.
The modeling of auditory roughness for signals with temporally asymmetric envelopes

To some extent, we are able to make observations on the size and the speed of rolling objects by just listening to its sound. Some properties of the sound the rolling object indicate that the object is either large or small and either rolling fast or slow. Recent research [15] suggested that auditory roughness might be an important temporal cue in our ability to differentiate, but it could not be underlined. In order to verify the suggestion, we need to apply a good auditory roughness model on the sounds of rolling objects. Sounds of rolling objects often have temporally asymmetric envelopes. Literature [37] shows that there is a significant difference in roughness between ramped and damped signals. These ramped and damped signals have temporally asymmetric envelopes and are the exact timereversed counterpart of each other. Ramped signals have a slowly increasing onset and a steep offset, whereas damped signals have a steep onset and a slowly decreasing offset. Current roughness models are not able to distinguish the difference between the roughness of ramped and damped signals. In order to estimate the roughness of rolling sounds, our model should be able to distinguish the roughness difference between ramped and damped signals. In this report, an auditory roughness model is developed consisting of four modules: a peripheral filter, an auditory filterbank, an adaptation module and a roughness extraction module. The latter three modules each contain multiple different implementations and the modules are tested on the difference they ascribe to ramped and damped signals. With all the implementations, twelve roughness models are constructed and they are subjected to the ramped and damped stimuli, as well as to a larger set of stimuli for which perceptual data is available. Finally, the roughness trends with respect to the size and speed of rolling balls are predicted. The adaptation module appears to be the key module in explaining the roughness difference between ramped and damped signals. Furthermore, the twelve obtained roughness models are able to achieve a good fit with respect to the large set of available perceptual roughness data. Finally, our models predict that the roughness of rolling balls varies significantly with the size and speed parameters of the balls. With increasing speed, the estimated roughness increases and with increasing diameter, the estimated roughness decreases. Roughness may thus be a temporal cue in the perception of size and speed of rolling objects.
Hemoglobin-mediated biomimetic synthesis of paramagnetic O2-evolving theranostic nanoprobes for MR imaging-guided enhanced photodynamic therapy of tumor

The hypoxic microenvironment in solid tumors severely limits the efficacy of photodynamic therapy (PDT). Therefore, the development of nanocarriers co-loaded with photosensitizers and oxygen, together with imaging guidance ability, is of great significance in cancer therapy. However, previously reported synthetic methods for these multi-functional probes are complicated, and the raw materials used are toxic. Methods: Herein, the human endogenous protein, hemoglobin (Hb), was used for the simultaneous biomimetic synthesis of Gd-based nanostructures and co-loading of Chlorine e6 (Ce6) and oxygen for alleviating the hypoxic environment of tumors and accomplishing magnetic resonance imaging (MRI)-guided enhanced PDT. The Gd@HbCe6-PEG nanoprobes were synthesized via a green and protein biomimetic approach. The physicochemical properties, including relaxivity, oxygen-carrying/release capability, and PDT efficacy of Gd@HbCe6-PEG, were measured in vitro and in vivo on tumor-bearing mice after intravenous injection. Morphologic and functional MRI were carried out to evaluate the efficacy of PDT. Results: The results demonstrated the successful synthesis of compact Gd@HbCe6-PEG nanostructures with desired multi-functionalities. Following treatment with the nanoparticles, the embedded MR moiety was effective in lighting tumor lesions and guiding therapy. The oxygen-carrying capability of Hb after biomimetic synthesis was confirmed by spectroscopic analysis and oxygen detector in vitro. Further, tumor oxygenation for alleviating tumor hypoxia in vivo after intravenous injection of Gd@HbCe6-PEG was verified by photoacoustic imaging and immunofluorescence staining. The potent treatment efficacy of PDT on early-stage was observed by the morphologic and functional MR imaging. Importantly, rapid renal clearance of the particles was observed after treatment. Conclusion: In this study, by using a human endogenous protein, we demonstrated the biomimetic synthesis of multi-functional nanoprobes for simultaneous tumor oxygenation and imaging-guided enhanced PDT. The therapeutic efficacy could be quantitatively confirmed at 6 h post PDT with diffusion-weighted imaging (DWI).
Review on first principle study for progression to investigate the properties of semiconductor compounds

Over the last decade, the first principle study, has achieved a great importance in the field of quantum chemistry, solid state physics and material science. This study is about to investigate the different prosperities of many-body electronic systems and it is a quantum mechanical simulation approach. Eventually, this approach has a tool to predict some new materials and their properties computationally. This method can save the use of chemical methods, which can be harmful to the environment. In this review article, the research field of first principle techniques has been explored for some important semiconductor materials.
Quasiperiodicity of some quasars important to ICRF-Gaia CRF link

The ESA/Gaia astrometric mission will provide a catalogue of about one billion stars and 600 000 quasars – QSOs, some of them could be the basis of a new optical reference frame. To link the future Gaia CRF (at optical wavelength) with the ICRF (based on the VLBI observations of quasars at radio wavelengths) it is required to observe a set of QSOs which are visible in the optical domain. Only about 10% of the ICRF sources (∼ 70 sources) are suitable for this task. Photometry stability of 47 candidate sources (Bourda et al. 2011) is of importance for astrometry and mentioned link. Our observations of these sources have been carried out by using three telescopes: two of them at the Astronomical Station Vidojevica (of the Astronomical Observatory of Belgrade) and the third one at the Rozhen National Astronomical Observatory (Bulgaria). We tested brightness variability of five candidate sources and their suitable comparison stars using the F–test. Only the brightness of one object does not show variability. For the four remaining objects we used the method of Least Squares to estimate sinusoidal parameters of quasiperiods of their light curves. The results of the mentioned brightness analysis of 5 objects and their 30 comparison stars (for the period July 2016 until August 2019) are presented here.
Numerical Evaluation About Spectral Reflection Properties of

ABSTRACT: In recent years, attention is increasingly focused on renewable energy. In order to increase the efficiency of solar thermal power generation which is one of renewable energy, it is important to improve the power generation efficiency by increasing the absorption rate of the solar energy collector while reducing the radiation loss. It is known that spectral characteristics control is possible by applying a microstructure to the surface. In this study, the effect of surface periodic microstructure on solar reflectance characteristics is evaluated. FDTD method is applied for electromagnetic field analysis. As the spectrum of solar radiation is distributed in the visible region and the near-infrared region, reflectance of uneven surface is calculated in the region of wavelength from 0.3 mm to 2.5 mm. Evaluation is performed by giving a plane wave to the dielectric with a periodic microstructure of the depth Lx, the opening length Ly, and the pitch length L, respectively. Poynting vector is used for calculating the reflectance. For the analysis of solar reflectance, calculations were made with reference to JIS K 5602: 2008. It can be seen that when the ratio of the concave portion to the convex portion is 1: 1, the solar reflectance becomes lower than in the other proportions. Also, when the depth was 0.1 mm, the reflectance was the lowest, 0.0350, which was about 31.5% of the solar reflectance of the flat plate.