Miracle-dz/UniFAR-FTUs huggingface dataset:
How Cognitive Linguistics Inspires HCI: Image Schemas and Image-Schematic Metaphors

ABSTRACT Cognitive linguistics, a recent discipline in the cognitive sciences, is firmly rooted in the idea that linguistic and cognitive abilities cannot be separated. This discipline is of interest to human–computer interaction (HCI) specialists concerned with finding out about users’ mental models and representing these in user interfaces. Central to cognitive linguistics are the theories of conceptual metaphor and image schemas. These theories have been influential in two areas of HCI: generating population stereotypes of physical-to-abstract mappings and inspiring user interface designs. The article reviews the theory and research into the application of image schemas and image-schematic metaphors in HCI. Special emphasis is put on strategies of image-schema sourcing. The theory and the available evidence suggest that the application of image schemas can contribute to user interfaces that are innovative, inclusive, and intuitive to use. The claim for inclusiveness currently has the weakest empirical support and needs to be substantiated by further research.
The Male Marital Satisfaction Following Treatment for Lower Urinary Tract Symptoms

The purpose of this study was to evaluate the effect of treatment on marital state and satisfaction in patients with lower urinary tract symptoms (LUTS). The study consisted of 213 patients with LUTS, of whom. 114 patients underwent alpha-blockers treatment and 99 underwent transit rethral resection of the prostate. All patients were assessed on their marital state and satisfaction at baseline, 3 months, 6 months, and 12 months, regardless of medical or surgical treatment. Using the Golombok-Rust Inventory of Marital State (Rust, Bennum, Crowe, & Golombok, 1998), we interviewed the patients. Before treatment, there was a high level of marital dissatisfaction because of prostatic Symptoms, which caused increased levels of discomfort in most patients. There was significant improvement in most patients after the 12-month follow up. We determined that LUTS has a significant impact on patients' quality of life and spousal relationships.
A Hybrid Positioning System for Indoor Navigation on Mobile Phones using Panoramic Images

In this paper, we propose a novel positioning system for indoor navigation which helps a user navigate easily to desired destinations in an unfamiliar indoor environment using his mobile phone. The system requires only the user’s mobile phone with its basic equipped sensors such as a camera and a compass. The system tracks user’s positions and orientations using a vision-based approach that utilizes 360o panoramic images captured in the environment. To improve the robustness of the vision-based method, we exploit a digital compass that is widely installed on modern mobile phones. This hybrid solution outperforms existing mobile phone positioning methods by reducing the error of position estimation to around 0.7 meters. In addition, to enable the proposed system working independently on mobile phone without the requirement of additional hardware or external infrastructure, we employ a modified version of a fast and robust feature matching scheme using Histogrammed Intensity Patch. The experiments show that the proposed positioning system achieves good performance while running on a mobile phone with a responding time of around 1 second.
Therapy of patients with rheumatoid arthritis: outcome of infliximab failures switched to etanercept.

OBJECTIVE The role of alternative tumor necrosis factor (TNF) antagonist therapies in the context of failure of initial TNF antagonist therapy in patients with rheumatoid arthritis (RA) has yet to be clearly defined. The goal of this study was to determine the efficacy of etanercept in patients who failed to respond to infliximab. METHODS Ninety-five patients with RA who failed to respond to infliximab and methotrexate were treated with etanercept (with continuation of concomitant methotrexate). Thirty-four patients never achieved a response to infliximab (primary nonresponse), 38 had an initial response to infliximab but relapsed (secondary nonresponse), and 23 demonstrated toxicity. Disease Activity Score in 28 joints (DAS28), European League Against Rheumatism (EULAR) response, and American College of Rheumatology (ACR) response were determined after 12 weeks of etanercept. RESULTS After 12 weeks of etanercept, 38% of patients achieved an ACR 20% response (ACR20) on etanercept. Of these, 24% and 15% achieved ACR50 and ACR70 responses, respectively. In the primary infliximab nonresponse group, 42%, 30%, and 15% achieved ACR20, ACR50, and ACR70 responses, respectively; the percentages for the secondary nonresponse group were 34%, 21%, and 14%, respectively. Significant DAS28 reductions were observed in the entire cohort and nonresponse subtype groups. Sixty-one percent of the cohort achieved either a moderate or good EULAR score (67% of primary and 56% of secondary infliximab failures). No toxicity was observed in patients who stopped infliximab due to intolerance; 19 of 23 continued etanercept after week 12. CONCLUSION This study confirms that etanercept is effective in patients who fail to respond to infliximab and suggests a higher response in patients who have never had a response to infliximab.
Human immunodeficiency virus infection of T-lymphoblastoid cells reduces intracellular pH

Alterations in plasma membrane function are induced by many cytopathic viruses, including human immunodeficiency virus type 1 (HIV-1). These alterations can result in changes in the intracellular content of ions and other small molecules and can contribute to cytolysis and death of the infected cell. The pH-sensitive fluorescent probe 2',7'-bis(2-carboxyethyl)-5,6-carboxyfluorescein-acetoxymethyl ester was used to quantitate intracellular pH (pHi) in HIV-1-infected T cells. Infection of cells from the CD4+ T-lymphoblastoid line HUT-78 (RH9 subclone) with HIV-1 strain LAI resulted in a significant decrease of pHi, from approximately 7.2 in mock-infected cells to below 6.7 by day 4 after infection, when cells were undergoing acute cytopathic effects. The pHi in persistently infected cells that survived the acute cytopathic effects of HIV-1 was approximately 6.8 to 7.0. Studies with amiloride, an inhibitor of the Na+/H+ exchange system, suggest that HIV-1-induced intracellular acidification in lymphocytes is due, in part, to dysfunction of this plasma membrane ion transport system. The alterations in pHi may mediate certain cytopathic effects of HIV-1, thereby contributing to depletion of CD4+ T lymphocytes in patients with AIDS.
Selective sorbents for solid-phase extraction based on molecularly imprinted polymers

Highly selective sorbents for solid-phase extraction (SPE) are desirable tools for the development of selective and sensitive methods for trace analysis. Molecular imprinting is an emerging technique that can yield analyte- or group-selective polymeric sorbents. Guest authors Ensing and Berggren and column editor Majors discuss the basic principles of molecular imprinting and compare the technique with conventional sorbent and immunoaffinity-based SPE. They use real-life examples to illustrate the potential of molecularly imprinted polymer-based SPE.
The GEPARD Data Collection Model – Protected Data Collection for the Gene Bank Parkinson's Disease Germany of the Competence Network on Parkinson's Disease (Datenerfassung in GEPARD – Die geschützte Datensammlung der Genbank Parkinson'sche Krankheit Deutschland des Kompetenznetzes Parkinson)

The analysis of the human genome facilitates the study of the relationship between genotypes and phenotypes. Research on diseases such as Parkinson's Disease (PD), partly determined by mutations and polymorphisms in several genes, requires a large number of DNA samples in conjunction with highly standardised clinical information. To support further discovery of genetic components of PD, the Competence Network on Parkinson's Disease (CNP e.V.) initiated the Gene Bank Parkinson's Disease Germany (GEPARD) and underwent a complex procedure to establish an internet-based data system that fulfils the legal requirements of the German data safety and protection laws. Die Analyse des menschlichen Genoms erleichtert die Erforschung der Beziehungen zwischen Genotypen und Phänotypen. In Fällen, in denen eine Krankheit teilweise durch Mutationen und Polymorphismen vieler Gene determiniert ist, wie beim Morbus Parkinson, benötigt die Forschung sehr viele Genproben mit standardisierten klinischen Informationen. Um die Entdeckung weiterer genetischer Komponenten der Parkinson-Krankheit zu unterstützen, initiierte das Kompetenznetz Parkinson (KNP) die Genbank Parkinson Deutschland (GEPARD). In einem komplexen Verfahren wurde ein internetbasiertes Datensystem etabliert, das den gesetzlichen Anforderungen an Datenschutz und -sicherheit genügt.
Principles of minimal residual disease detection for hematopoietic neoplasms by flow cytometry

Flow cytometry has become an indispensible tool for the diagnosis and classification of hematopoietic neoplasms. The ability to rapidly distinguish cellular subpopulations via multiparametric assessment of quantitative differences in antigen expression on single cells and enumerate the relative sizes of the resulting subpopulations is a key feature of the technology. More recently, these capabilities have been expanded to include the identification and enumeration of rare subpopulations within complex cellular mixtures, for example, blood or bone marrow, leading to the application for post‐therapeutic monitoring or minimal residual disease detection. This review will briefly present the principles to be considered in the construction and use of flow cytometric assays for minimal residual disease detection including the use of informative antibody combinations, the impact of immunophenotypic instability, enumeration, assay sensitivity, and reproducibility. © 2015 International Clinical Cytometry Society
An Evaluated Model Based on the Variance of Distance Ratios for Nonlinear Dimensionality Reduction Algorithms

We analyze and compare three evaluation models for nonlinear dimensionality reduction algorithms including the evaluation model based on the stress function, the evaluation model based on the residual variance and the evaluation model based on the dy-dx representation. On the base of the dy-dx representation, we propose an evaluation model based on the variance of distance ratios. The model is on the assumption that a good dimensionality reduction technique should best preserve the proportion between distances in the original space and corresponding distances in the embedding space. Experiments illustrate that the model not only can evaluate results from the same algorithm with various parameters, but also can compare results from different methods.
An efficient quorum-based scheme for managing replicated data in distributed systems

A new quorum-based replica control scheme for managing replicated data in distributed systems is proposed. We first introduce a concept called relaxed difference pair to establish the basics for cyclic read-write coteries. A simple and efficient model is then presented to facilitate the construction of read-write coteries. The read-write coteries generated by the model are symmetric. The proposed scheme can be applied to arbitrary number of data copies. More importantly, by introducing a parameter in the construction model, our scheme provides the flexibility of adjusting the sizes of read and write quorums. Such flexibility allows one to construct a read-write coterie that best suits the environment of the target system.
FROM INTERNATIONAL EQUIVALENCE TO NATIONAL TRACEABILITY IN RADIONUCLDE METROLOGY

The methods for absolute (direct) standardization, coincidence method for radionuclides emitting several simultaneous radiations and liquid scintillation counting for radionuclides emitting a single radiation, the obtained results, as the technical basis for a primary radioactivity standard recognition, are shortly reviewed. They were published in many scientific papers. The key and supplementary comparisons organized by the CIPM-CCRI(II), EUROMET, other supplementary IAEA comparisons, former COMECOM, as well as bilateral comparisons results, served as basis for the recognition of the international equivalence of the Romanian radioactivity standards. In order to assure the national traceability, our laboratory prepared and delivered radioactive standards, standardized radioactive sources, calibrated and checked radioactivity measurement equipment and organized national comparisons. The laboratory, attested by the BRML and notified by the CNCAN, is also on way to be accredited by the RENAR, as a calibration and testing laboratory, according to the RS EN ISO/IEC 17025:2005 standard requirements. Its QS was recognized by the Q-TC EUROMET
An Efficient Educational Material Exploration using Extracted Concepts

There are huge amount of Open Educational Resources (OER) provided by academic institutes now. Learners have an advantaged environment in which they can use the educational materials for free in their learning. General text search techniques, however, are not enough to provide an efficient search function for them. This drawback makes it difficult for learners to fully exploit the promising OER. We propose to solve the problem by providing an environment in which learners can search for educational materials efficiently using a set of concept networks derived from the existing OER. The result of experiment with the actual OER shows the availability of the proposed method.
of Adalimumab MTX Combination on Serum (NF-κB) and Caspase3 in Iraqi Patients with Rheumatoid Arthritis

: Background: Rheumatoid arthritis (RA) is a chronic inflammatory diseasewith variable degrees of bone and joints damage. Treatment with methotrexate (MTX) +/- biological agents such adalimumab(ADA); may produce dramatically changes in the progression and severity of RA which in turn affect expression of inflammatory pathway; inflammatory cytokines;NF Қ B and caspases-3. Objective: To assess effects of treatment by MTX and MTX-adalimumabon levels of inflammatory signaling. Subjects and methods:Open label three groups prospective study on 100 Iraqi patients with RA plus 50 apparently healthy subjects, Patients were allocated to take MTX and MTX plus ADA. Results:Serum(NF-κB) Initially; was significantly elevated In RA groups of patients. Which in turn indicate the activation of this transcription factor.MTX-ADA treatment resulted in significant (NF-κB) lowering as compared to MTX. Serumcaspases-3 in RA groups; initially were significantly lower than in normal subjects. After 3months of treatment; A significant elevation in caspases-3found in ADA+ MTX group as compared with initial value and MTX group. Conclusion: Use of adalimumab–MTX combination may result in lowering level of expression of serum NF- Қ B used in regulation of inflammatory signaling and significant changes in caspase-3 level expressed in serum indicating increase cellular apoptosis.
Assisted Optimisation of the Robot Dynamic Behavior with Magnetorheological Damper

The paper showed the assisted research of one magnetorheological damper and the influences to the dynamic behavior of the industrial robots. The research contents the assisted theoretical simulation of the new mathematical model, the parameterization of the known characteristics of the magnetorheological damper and the assisted establish of the influences of the model coefficients to the characteristics parameters. In the assisted experimental research was established the values of all coefficients of the proper mathematical model to assure the concordance between the experimental and the theoretical characteristics. By knowing the real mathematical model of the damper was possible to develop the new matrix -vector form of the force- moment and the research of the global dynamic behavior of the industrial robot with proper smart damper system.
Factors Associated with Successful Tracheal Intubation of Children with Sevoflurane and No Muscle Relaxant

Better definition of end points required to achieve successful tracheal intubation after induction with sevoflurane could improve patient care. The authors therefore designed a study that could determine, with meaningful confidence intervals, the time required to successfully intubate 80% of children by using 8% inspired sevoflurane and no muscle relaxant. We hypothesized that the time required could vary by age or body mass index. One-hundred fifty-three ASA physical status I or II patients received induction with 8% sevoflurane in 60% nitrous oxide with discontinuation of nitrous oxide 1 min after the start of the induction. The time until laryngoscopy remained close to the time required to achieve 80% successful intubation by varying induction time according to the success rate in each group of five patients. A probit model of induction time and age found that both were predictive of successful intubation (P values of 0.006 and 0.02, respectively). The induction times needed to achieve 80% successful intubation were 137 s (95% confidence interval, 94.6–159 s) and 187 s (153–230 s) for ages 1–4 yr and 4–8 yr, respectively. The persistence of spontaneous ventilation at the time of laryngoscopy, despite attempts to control ventilation, was associated with poor intubation conditions (P < 0.001).
Effects of Indoor, Outdoor, and Personal Exposure to Particulate Air Pollution on Cardiovascular Physiology and Systemic Mediators in Seniors

Objective: To investigate the associations between exposure to particulate air pollution and changes in cardiovascular function and plasma mediators in seniors. Methods: We monitored daily indoor and outdoor black carbon and particulate matter ≤2.5 &mgr;m (pm2.5) and personal pm2.5 repeatedly for 28 nonsmoking seniors. We then measured their blood pressure, heart rate, and brachial artery function, and determined plasma mediators of inflammation, vascular function, and oxidative stress. We tested associations using mixed-effects models. Results: Increases in black carbon and pm2.5 were associated with increases in blood pressure, heart rate, endothelin-1, vascular endothelial growth factor, and oxidative stress marker thiobarbituric acid reactive substances, and a decrease in brachial artery diameter (P < 0.05). Conclusion: Daily exposure to particulate pollution, likely traffic-related, may result in adverse effects on cardiovascular function and blood mediators that modulate vascular system in seniors.
A Nontranscriptional Role for HIF-1α as a Direct Inhibitor of DNA Replication

In response to hypoxia, HIF-1α induces cell cycle arrest by inhibiting a helicase complex that unwinds DNA in preparation for replication. Staying Wound Up During Hypoxia Decreased oxygen availability (a condition called hypoxia) triggers various cellular responses, such as increased activity of hypoxia-inducible factor 1 (HIF-1), a transcription factor that activates genes involved in helping cells to survive oxygen deprivation. Hubbi et al. found that the HIF-1α subunit also had a nontranscriptional role in cellular responses to hypoxia. Hypoxic cells undergo cell cycle arrest, and HIF-1α altered interactions between the minichromosome maintenance (MCM) helicase, which unwinds DNA in preparation for replication, and various binding partners, leading to inhibition of MCM helicase activation and decreased DNA replication. HIF-1α mutants lacking transcriptional activity retained the ability to decrease DNA replication and to induce cell cycle arrest. HIF-1α can therefore mediate adaptive cellular responses to hypoxia through both transcriptional and nontranscriptional mechanisms. Cell cycle arrest in response to hypoxia is a fundamental physiological mechanism to maintain a balance between O2 supply and demand. Many of the cellular responses to reduced O2 availability are mediated through the transcriptional activity of hypoxia-inducible factor 1 (HIF-1). We report a role for the isolated HIF-1α subunit as an inhibitor of DNA replication, and this role was independent of HIF-1β and transcriptional regulation. In response to hypoxia, HIF-1α bound to Cdc6, a protein that is essential for loading of the minichromosome maintenance (MCM) complex (which has DNA helicase activity) onto DNA, and promoted the interaction between Cdc6 and the MCM complex. Although the interaction between Cdc6 and the MCM complex increased the association of the MCM proteins with chromatin, the binding of HIF-1α to the complex decreased phosphorylation and activation of the MCM complex by the kinase Cdc7. As a result, HIF-1α inhibited firing of replication origins, decreased DNA replication, and induced cell cycle arrest in various cell types. These findings establish a transcription-independent mechanism by which the stabilization of HIF-1α leads to cell cycle arrest in response to hypoxia.
Implementation model predictive control (MPC) algorithm-3 for inverted pendulum

Model Predictive Control (MPC) is based on the idea to produce control input as a solution to real-time optimization problem. Optimization itself is based on the system model. MPC is used to solve multivariable control problem which has more than one variable that may have significant effect on the process. The advantage of MPC is that MPC can works effectively within constraints of the real actuator which are relatively narrow. The disadvantage of MPC lies on its complex algorithm that needs longer time than the other controller. This paper discusses the MPC application for inverted pendulum. The algorithm used is algorithm-3 for floating point. The general guidelines are modeling the system, designing the system using MATLAB, simulating the design using MATLAB, implementing the MPC algorithm on AVR ATmega32 and analyzing the result. After the guideline have been implemented, it can be seen that MPC algorithm-3 with 9 horizon and 1 iteration of quadratic programming can return the pendulum rod at the balance point by the time external force applied.
Do we expect ESD failures in an EPA designed according to international standards? The need for a process related risk analysis

ESD failures can occur in ESD protected areas that are designed according to the latest ESD standards like ANSI S20.20 or IEC 61340-5-1. The root cause for the failures can normally only be found by a detailed analysis of the whole production flow. This paper shows what hazards for ESD damages can occur in a typical process flow of a typical PCB manufacturing line, how the risk is going to be analyzed, and how it can be minimized. This method will be explained with some examples from the field.