Miracle-dz/UniFAR-FTUs huggingface dataset:
Stackelberg Games for Vaccine Design

Stackelberg game models have recently seen considerable practical and academic success in security applications, with defender as the leader, and attacker the follower. The key conceptual insight of Stackelberg security games is that defense needs to be proactive, optimally accounting for attacker's response to a defensive posture. We propose that this insight has relevance in another important application domain: vaccination. Vaccination therapies are important tools in the battle against infectious diseases such as HIV and influenza. However, many viruses, including HIV, can rapidly escape the therapeutic effect through a sequence of mutations. We propose to design vaccines, or, equivalently, antibody sequences, that make such evasion difficult. Formally, we model the interaction between a vaccine and a virus as a Stackelberg game in which the vaccine designer chooses an antibody, and the virus chooses a minimal sequence of mutations to escape it. Our crucial observation is that we can leverage protein modeling software, Rosetta, as an oracle to compute binding score for an input virus-antibody pair. This observation enables us to develop a fully automated bi-level stochastic optimization algorithm for optimal antibody "commitment" strategy. A key technical challenge is that score calculation for each possible antibody-virus pair is intractable. We therefore propose a novel simulation-based bi-level optimization algorithm to address this, which consists of three elements: first, application of local search, using a native antibody sequence as leverage, second, machine learning to predict binding for antibody-virus pairs, and third, a Poisson regression to predict escape costs as a function of antibody sequence assignment. We demonstrate the effectiveness of the proposed methods, and exhibit an antibody with a far higher escape cost (7) than the native (1).
VALUES OF AEROBIC CAPACITY IN HANDBALL AND VOLLEYBALL PLAYERS

Physical capacity of athletes is an important element of success in sports achievements. Aerobic capacity has been accepted as its major component. Maximal oxygen uptake (VO2max) has been regarded by majority of authors as the best indicator of aerobic capacity of an organism, and at the same time, the best indicator of an athlete's physical capacity. The aim of the investigation was to analyze the aerobic capacity as an indicator of physical capacity of athletes, differences in their aerobic capacity with regard to the kind of sport they are practicing, as well as the differences obtained when compared to physically inactive subjects. The investigation included the determination of absolute and relative VO2max in the total of 70 male examinees. The examinees were divided into two groups of active athletes (handball players (n=24) and volleyball players (n=20) of different profiles, while the third group of non-athletes served as control group. Maximal oxygen uptake was determined by performing the Astrand 6 minute cycle test. Peak values of VO2 max were recorded in the group of handball players (4,27±0,29 l/min), and they were statistically significantly higher (p<0,001) compared to other examined groups. In the group of volleyball players the oxygen uptake was 3,98±0,19 l/min, while statistically significantly lower values were reported in the group of non-athletes compared to the groups of athletes (p<0,01). A similar ratio of VO2 max values was also shown by the analysis of values expressed in relative units. Our results showed that peak values of VO2 max were obtained in handball players, and that handball as a sport requires higher degree of endurance compared to volleyball. Having considered the morphological and functional changes which are the consequence of the training process, it can be concluded that VO2 max values are statistically significantly higher in the groups of athletes compared to the group of non-athletes.
A Novel Approach for Estimating the Cognition Level of a Student in Adaptive Learning System

Abstract Learning is the process of acquiring new knowledge, behaviors, skills, values or preferences and may involve synthesizing different types of information. Human learning may occur as part of education, personal development or training and can be enhanced. For the enhancement of student learning performance different methods are proposed. In this paper the student cognition level is estimated to enhance the student learning performance. Cognition is the scientific term for “the process of thought”. The students’ understanding of knowledge is marked by different levels by different people like Allen’s cognition levels, Bloom’s Taxonomy of cognition levels etc. In this paper, the student cognition level is estimated using Fuzzy Set Method. The cognition level’s estimation is mainly through inspecting student’s practice and examination records. The cognition level is given for each and every question in the exam and the overall cognition level is calculated.
Realtime HDR (High Dynamic Range) Image Processing For Digital Eye Glass Seeing Aid

RealTime HDR (High Dynamic Range) Image Processing For Digital Glass Seeing Aid Jason Huang Master of Applied Science Graduate Department of Electrical and Computer Engineering University of Toronto 2013 The work of this thesis is motivated by the benefit of real-time HDR image processing which helps constructing better seeing aid devices for day-to-day uses. The seeing aids with HDR can achieve dynamic range greater than human eyes to capture visuals under various light conditions. Further, it helps range sensing devices to read the light codes better. This requires realtime HDR image processing running at 24 FPS. In this thesis, we demonstrate implementation of several HDR image compositing and tone mapping methods in CUDA to achieve realtime performance. In addition, a new tone mapping method termed PPEM is introduced as a novel tone mapping method by adjusting per pixel exposure. Finally, we apply relevant HDR methods to range sensing devices for robust reading.
The Treatment of Elderly Patients with Aggressive Non-Hodgkin’s Lymphoma

textabstractThe treatment of elderly patients with an aggressive non-Hodgkin’s lymphoma has gradually changed over the last decades. The first publications concerning elderly patients with lymphoma emphasized the increased toxicity and poor outcome of this patient group. (1-3) The aim of many subsequent studies has been to decrease toxicity. (4-6) Most of these studies however reported decreased response rates and deterioration of survival if age adapted therapy was used. It also became evident that doxorubicin proved to be a toxic, but essential drug in any regimen prescribed with a curative intention. (7-9) The development of recombinant granulocyte colony-stimulating factor (G-CSF) raised expectations that this growth factor could improve the results of therapy because it would become possible to maintain the dose-intensity of the chemotherapy regimen by inducing rapid hematopoietic recovery. (10) Moreover, a shorter duration of the neutropenic phase could probably reduce the incidence of neutropenic fever, bacterial infections and the number of hospital admissions. (11, 12) In the current thesis the results of a large prospective multicenter clinical trial are reported. This trial was designed to investigate if prophylactic G-CSF administration could improve the poor results of treatment in elderly patients with an aggressive non-Hodgkin’s lymphoma. The primary question was whether a higher relative dose-intensity would lead to improved treatment outcome. Secondary endpoints were the quality of life and the cost-effectiveness associated with such treatment. This trial was supported by the Dutch government.
Audience Participation: Essays on Inclusion in Performance

Acknowledgments Introduction Ethics of the Witness: The Participatory Dances of Cie Felix Ruckert by Joshua Abrams Reaction Tactics: Redefining Postmodern Spectator Response and Expectations by Katherine Adamenko Still Signaling through the Flames: The Living Theatre's Use of Audience Participation in the 1990s by Davie Callaghan It Matters for whom You Dance: Audience Participation in Rasa Theory by Uttara Asha Coorlawala Audience Participation in the Eighteenth-Century London Theatre by Judith W. Fisher The Challenge of Participation: Audiences at Living Stage Theatre Company by Susan C. Haedicke Manipulation of the Mind: Fiction in the Performances of Penn and Teller by Susan Kattwinkel Looking at Looking (at Looking): Experiments in the Interrogation of Spectating by Joanne Klein The Audience in Cyberspace: Audience-Performer Interactivity in Online Performances by Nina LeNoir Once upon a Time: The Story of the Pantominme Audience by Dawn Lewcock Audience at Risk: Space and Spectators at Feminist Performance by Judith Sebesta "Walking in the Steps of Your Forefathers": Locating the Actor and the Audience in Derry's Siege Pageant by Patrick Tuite Community-Based Theatre: A Participatory Model for Social Transformation by Mark S Weinberg The (Oc)cult of Personality: Initiating the Audience into The Edwardian Mysteries by J. Lawton Winslade Index
Caching in large-scale distributed file systems

This thesis examines the problem of cache organization for very large-scale distributed file systems (DFSs). Conventional DFSs, based on the client-server model, suffer from bottlenecks when the total client load exceeds the server's capacity. Previous work has suggested that hierarchical client organizations can ameliorate the problem somewhat, but at the expense of a substantial increase in client latency. An analysis of existing DFS workloads reveals that there is considerable regularity in client file access patterns and that widely shared files lend themselves especially well to caching techniques. In particular, a large proportion of "cache miss" traffic is for files that are already copied in another client's cache. If clients can share these cached files, the server's load can be reduced by a potentially large margin, making larger-scale systems possible. We introduce the notion of dynamic hierarchical caching, in which adaptive client hierarchies are constructed on a file-by-file basis. Trace-driven simulation and workload-driven runs of a prototype file system suggest that dynamic hierarchies can reduce server load substantially without the client performance penalties associated with more static schemes.
A Synthetically Improved Method Based on Apriori Algorithm

There are some disadvantages of the Apriori algorithm，such as too many scan of the database and many redundant middle itemsets to be generated. In this paper, we propose an improved algorithm, OApriori, with a synthetical method: (1) pruning strategy, (2) connection strategy, (3) reducing the scanning scale of database. We have performed extensive experiments and compared the performance of two algorithms. It was found that the improved algorithm reduces the counts of unnecessary candidate itemsets, accelerates the speed of the algorithm.
Births, Infants and Children: an Econometric Portrait of Women and Children in India

This paper undertakes an econometric analysis of the constellation of factors that serve to determine some outcomes with respect to demography and to schooling in India. These are: the numbers of pregnancies, live births and infant survivals to women and the chances of children being enrolled at school and, if enrolled, of continuing in school. The econometric estimates are based on unit record data from a survey - carried out by the National Council of Applied Economic Research (NCAER), New Delhi - of 33,000 rural households - encompassing 195,000 individuals - spread over 1,765 villages, in 195 districts, in 16 states of India. The study concludes that a broad spectrum of factors affect these outcomes. The literacy of women is important but so is the literacy of men. Infrastructure, in the form of safe drinking water and easy access to medical facilities, is important for infant survivals and, in the shape of easy access to schools, is important for school enrolment. Parental occupation matters for both infant survivals and schooling: children born to women who work as labourers are disadvantaged, relative to other children, in terms of their chances both of surviving infancy and, if they do survive, of receiving schooling. The number of siblings that a child has affects his/her schooling outcomes and gender, religion and region play an important role.
Usabilidad de los tag-clouds: estudio mediante eye-tracking.

Los tag-clouds, o nubes de etiquetas, son componentes de interfaz en forma de lista compacta de palabras clave, que permiten al usuario explorar y navegar por conjuntos documentales. Si bien en los últimos años han gozado de gran popularidad en el entorno Web, también es cierto que, como interfaces visuales de recuperación de información, presentan evidentes problemas de usabilidad. El presente trabajo se propone indagar en la usabilidad de los tag-clouds, a través de la revisión bibliográfica y un estudio con usuarios utilizando técnicas de eye-tracking o seguimiento visual. Los resultados demuestran que tanto el tamaño de fuente como la forma del tag-cloud tienen una clara influencia en la exploración visual de los usuarios. Respecto a la ordenación de los tags, si bien la ordenación alfabética no ofrece ventajas en tareas de búsqueda exploratoria, los resultados sugieren que la agrupación semántica tampoco supone una mejora en términos de eficiencia en tareas de localización visual de los tags. Finalmente se proponen posibles mejoras en la presentación de los tag-clouds agrupados semánticamente, así como futuras líneas de investigación
Talkin' bout a revolution: Cultural Effects on the Transition from Oral to Written Literature

Using language and writing to distinguish cultures from each other is commonplace. They are defining characteristics of culture that enable members to identify themselves within their group - by having communication they are tied together. Oral communication is the key identifier for Nyikina people of northern-Western Australia. However, Nyikina language is severely endangered, and risks being lost altogether. If the language were to die, Nyikina people would lose a huge part of their cultural identity. Working with the Nyikina community as part of a language revitalisation project sparked my interest in the transition from oral to written literature within the Mediterranean. Why did Nyikina not develop their own script, but Minoans and Etruscans did? It would be beneficial to have Etruscan literature or sound recordings describing how the Etruscan language was influenced by Phoenician and Greek cultures, and to know why they created their own alphabet using elements from both colonising influences. Hence, the experience and situation regarding the Nyikina language may provide a general paradigm for understanding and extrapolating the contextual situations of Minoans and Etruscans with respect to their languages, and vice-versa. This was the spring-board to a Masters thesis exploring such changes.
Grammatical analysis of Hindi sentences using connectionist approach

Abstract: This paper presents a simple connectionist approach to parsing of a subset of sentences in the Hindi language, using Rule based Connectionist Networks (RBCN) as suggested by Fu in 1993. The basic grammar rules representing Kernel Hindi sentences have been used to determine the initial topology of the RBCN. The RBCN is based on a multilayer perceptron, trained using the backpropagation algorithm. The terminal symbols defined in the language structure are mapped onto the input nodes, the non‐terminals onto hidden nodes and the start symbol onto the single output node of the network structure. The training instances are sentences of arbitrary, but fixed maximum length and fixed word order.
Reannotation and Analysis of Clinical and Chemotherapy Outcomes in the Ovarian Data Set From The Cancer Genome Atlas.

PURPOSE The ovarian cancer data set from The Cancer Genome Atlas integrates genomic and proteomic data with clinical annotations based on chart abstractions. We aimed to develop an algorithm to create a matching, more accessible clinical data set cataloging time to treatment failure (TTF) of sequential lines of treatment in patients with serous ovarian cancers. MATERIALS AND METHODS The master data set of 587 patients with serous ovarian cancer was condensed into a more homogeneous and clinically relevant population comprised of high-risk patients with both grade 3 cancers and stage III or IV disease, resulting in a subgroup of 450 patients. We quantified the TTF of different lines of therapy as well as different therapeutic combinations by extrapolating from the time of starting one therapy to the time of starting a subsequent therapy. RESULTS The overall survival (OS) of patients was highly related to platinum sensitivity status, with median OS times of 56.6, 27.0, and 11.6 months in patients who had platinum-sensitive, -resistant, or -refractory disease, respectively. In high-risk patients, the median TTFs were 14.8, 10.2, 5.7, and 4.1 months with the first, second, third, and fourth lines of chemotherapy, respectively. Patients with stable disease after first-line therapy had similar OS outcomes as patients with partial remissions (34.4 v 33.7 months, respectively). CONCLUSION This new data set enhances the clinical annotation by providing exploitable chemotherapy benefit data that can now be paired with genomic and proteomic data within The Cancer Genome Atlas data. The major determinant of OS in this study was platinum sensitivity status. TTF decreased with each successive line of therapy. However, patients who achieved only stable disease with first-line therapy had OS similar to those with partial remission.
An assessment of the role of different cadres of animal health service providers in animal health service delivery in Kiambu district, Kenya.

This study was found necessary due to the changing nature o f the veterinary services in Kenya whereby, hitherto, the delivery o f veterinary services had been solely dependent on the government until some components were privatised. Privatisation was ad hoc as there were no policies in place to ensure quality of the services provided. The overall objective of the study was therefore to assess the role of private animal health service providers in the provision of veterinary services in Kiambu District, Kenya. The specific objectives were: 1) To identify and categorise the various ways farmers access veterinary services in Kiambu District, Central Kenya; 2) To identify the problems experienced by veterinary practitioners and farmers in the animal health service delivery in the district; and 3) To identify the categories of veterinary service providers most frequently consulted by farmers and the reasons behind it. The study was conducted in Kiambu District, Kenya. The district is located in Central Province. A total of 125 farmers and 21 animal health service providers were randomly selected for the study. All data on household characteristics and animal health service providers was obtained through questionnaires, which were administered via personal interviews to the selected farmers and the animal health service providers. The data was entered and managed in MS Excel. The data was then exported to SPSS Statistical Software for statistical analysis on animal health service providers and household characteristics.
Tension-compression strength asymmetry of nanocrystalline α-Fe2O3+fcc-Al ceramic-metal composites

The dependence on composition and loading direction of the strength of nanocrystalline α-Fe2O3+fcc-Al composites is analyzed using molecular dynamics simulations with a recently developed multicomponent interatomic potential. Compressive strength values are found to be higher than the tensile strength values at all volume fractions of the phases. Reverse Hall-Petch relations are observed for tension and forward Hall-Petch relations are observed for compression. The observed asymmetry in behavior and the direct or reverse nature of the Hall-Petch relations are found to reflect the different manners in which pairwise electrostatic forces influence grain boundary sliding which is the primary deformation mechanism.
A history of reading

This study of the history of reading goes from the earliest examples of the clay tablets and cuneiform of ancient Mesopotamia and Egypt via the invention of printing in the 15th century to the birth of a mass reading public and today's digital revolution. It argues that it is the demands and expectations of the reader, acting alongside the creative will of the writer, that is the evolutionary motor of literary forms and genres. From man's first use of the written word simply as a form of reference, to the emergence of the first holy or devotional texts, and onto the development of fictions, both poetic and novelistic, this work aims to both challenge and enlighten.
High-Speed Research: Sonic Boom, volume 2

A High-Speed Sonic Boom Workshop was held at NASA Langley Research Center on February 25-27, 1992. The purpose of the workshop was to make presentations on current research activities and accomplishments and to assess progress in the area of sonic boom since the program was initiated in FY-90. Twenty-nine papers were presented during the 2-1/2 day workshop. Attendees included representatives from academia, industry, and government who are actively involved in sonic-boom research. Volume 2 contains papers related to low sonic-boom design and analysis using both linear theory and higher order computational fluid dynamics (CFD) methods.
An architectural comparison of contemporary apporaches and products for integrating heterogeneous information systems

1.0 1.1. 1.2. 1.3. 1.4. 1.5. 1.6. 1.7. INTRODUCTION Background. Functional Deficiencies. Levels of Integration. Constraints. Models and Schemata. Languages . General Directions. 1-1 . 1-2 . 1-4 . 1-7 . 1-8 . 1-12 . 1-13 SECTION 2.0 HIGHLIGHTS OF PRINCIPAL PRODUCTS AND APPROACHES 2.1. BBN Systems and Technologies: Cronus . 2-2 2.2. Booz Allen: IDIMS . 2-4.2-4 2.3. Cambridge Technology Group: SURROUND . 2-6 2.4. Cincom: SUPRA . 2-8 2.5. Cognos Corporation: POWERHOUSE . 2-10 2.6. Control Data Corporation: ASCENT . 2-12 2.7. Control Data Corporation: CDM*PLUS . 2-15 2.8. Data Integration, Inc.: Mermaid . 2-17 2.9. Digital Equipment Corp.: Rdb/VMS, DBMS . 2-20 2.10. Gupta Technologies, Inc.: SQL System . 2-22 2.11. Honeywell Federal Systems, Database Testbed System. 2.12. IBM: DB2, SQL/DS, SAA, and 2.13. Information Builders, Inc.: Inc.: others FOCNE Distribut . ····. Te.e. es 2.14. Interbase Software Corporation: INTERBA 2.15. Massachusetts Institute of Technology: Composite Information Systems. 2.16. Metaphor Computer Systems, Inc.: DIS. 2.17. 0n-Line Software International, Inc.: RAMIS Information System . 2.18. Oracle Corporation: ORACLE. 2.19. Relational Technology, Inc.: INGRES. 2.20. Software AG: ADABAS. 2.21. Sybase, Inc.: SYBASE. 2.22. Tandem Computers Incorporated: NonStop 2.23. TRW: TDIE . 2.24. Xerox Advanced Multibase. Information Technology: . · . · . SE. ed . 2-24 . 2-27 . 2-30 . 2-32 . 2-34 . 2-38 .