Miracle-dz/UniFAR-FTUs huggingface dataset:
Thalidomide and bortezomib overcome the prognostic significance of proliferative index in multiple myeloma.

UNLABELLED We analyzed proliferative index of myeloma plasmocytes (PC-PI) in acohort of 217 patients with multiple myeloma (MM) treated with conventional chemotherapy and biological agents, thalidomide and bortezomib. In the whole group was adifference between overall survival (OS) favoring patients with PC-PI ven after 40 months (median overall survival 25 vs 10months, p= 0.015), whereas in the group treated with thalidomide and bortezomib was no difference, with medians over 39 months. Even patients with low PC-PI profited from the treatment with novel drugs. Presented results suggest that the treatment of MM with novel agents overcomes the prognostic significance of PC-PI and should be used in all MM patients. KEYWORDS myeloma -prognostication -proliferative index -biological therapy.
yeast three-hybrid system Recognition of RNA by the p 53 tumor suppressor protein in the References

The p53 tumor suppressor protein is a homotetrameric transcription factor whose gene is mutated in nearly half of all human cancers. In an unrelated screen of RNA/protein interactions using the yeast three-hybrid system, we inadvertently detected p53 interactions with several different RNAs. A literature review revealed previous reports of both sequence-specific and -nonspecific interactions between p53 and RNA. Using yeast three-hybrid selections to identify preferred RNA partners for p53, we failed to identify primary RNA sequences or obvious secondary structures required for p53 binding. The cationic p53 C-terminus was shown to be required for RNA binding in yeast. We show that while p53 strongly discriminates between certain RNAs in the yeast three-hybrid assay, the same RNAs are bound equally by p53 in vitro. We further show that the p53 RNA-binding preferences in yeast are mirrored almost exactly by a recombinant tetrameric form of the HIV-1 nucleocapsid (NC) protein thought to be a sequence-nonspecific RNA-binding protein. However, the possibility of specific RNA binding by p53 could not be ruled out because p53 and HIV-1 NC displayed certain differences in RNA-binding preference. We conclude that (1) p53 binds RNA in vivo, (2) RNA binding by p53 is largely sequence-nonspecific in the yeast nucleus, (3) some structure-specific RNA binding by p53 cannot be ruled out, and (4) caution is required when interpreting results of RNA screens in the yeast threehybrid system because sequence-dependent differences in RNA folding and display can masquerade as sequence-dependent differences in protein recognition.
Crossing the Border : The Framing of Global Migration by National News Media

Migration is a human experience that brought civilization to every corner of the globe. However, its modern manifestation threatens stability, human rights, resources, and security. For those outside migration’s immediate reach, the news media is the source for public understanding of its flows and consequences. Through a cross-national comparison, this study investigated how different national news media frame migration to their audiences. Examining recent online news publications from the United States, Germany, and Spain, this study concluded that national news media construct multiple frames of migration, maintain a significantly international focus, and often emphasize their discontent with national governments’ handling of migration issues.
Statistical Analysis Using PLS of a Project-Based Learning Application in Electrical Engineering

Traditional teaching has evolved little in the last century, with roots in unilateral knowledge transfer where the teacher is responsible for all steps of the teaching-learning process. Existing methodologies try to change this paradigm, supported by the freedom brought by the curricular guidelines. This work proposes the application of Project-Based Learning (PjBL) as an addition to what is already happening in the classroom, trying to identify in the Electrical Engineering Department of Blumenau Regional University the profile of teachers and students. This information is used as a base in order to apply an interdisciplinary project that seeks to develop cognitive ability and the search for answers of the students. The methodology was shaped for a night course where students must conciliate, in most cases, an external full-time job with the college education. Through its application, it was statistically possible to understand how knowledge interacts with the self-esteem and with the self-actualization of the student, forming a cycle of learning which is indirectly strengthened by cooperation (through self-esteem and self-realization). Therefore, it is possible to understand that a motivated student is a student more likely to grasp the knowledge involved in the project, which in turn generates more motivation and makes the cycle reload.
Research of Housing Loan Credit Evaluation Based SVM

Credit risk is the primary source of risk to financial institutions. Support vector machine (SVM) is a good classifier to solve binary classification problem and the learning results possess stronger robustness. The attribute reduction of rough set has been applied as preprocessor, then resolving the problem of the application of SVM in housing loan credit evaluation, such as the choice of kernel function and parameters, the problem of unbalance data. The experiment show: Gausslan model is suitable better for practical application, grid-search method adjusts these penalty parameters to achieve better generalization performances in the application, respectively penalty SVM(RP_SVM) can resolve unbalance problem efficiency.
Compressive Sensing Imaging of Non-Sparse 2D Scatterers by a Total-Variation Approach Within the Born Approximation

The problem of imaging two-dimensional “non-sparse” scatterers with piecewise-constant contrast is solved through an innovative total-variation compressive sensing (TV-CS) technique. Under Born approximation (BA), the time-harmonic two-dimensional inverse scattering problem is reformulated into an equivalent Augmented Lagrangian one according to the TV-CS formulation. The resulting unconstrained functional is then minimized by means of a deterministic alternating direction algorithm. Selected results from a numerical assessment are discussed to give the interested reader some insights on the accuracy, the flexibility, the robustness, and the efficiency of the TV-CS inversion scheme also in comparison with available implementations of state-of-the-art inversion methods still formulated within the BA.
Design-Space Exploration of Biologically-Inspired Visual Object Recognition Algorithms Using CPUs , GPUs , and FPGAs

In recent years, biologically-inspired visual object recognition algorithms – those that aim to mirror the computations performed by the brain's visual system – have emerged as exceptionally promising candidates in object and face recognition research, achieving impressive performance on a range of object and face recognition tasks. While these algorithms typically require a large number of operations per image analyzed, recent advances in many-core parallel computing hardware have enabled practical consideration of relatively large biologically-inspired systems. Here, we focus on a key operation found in this class of models, parallel convolution, and explore the design-space of implementations. Specifically, we compare CPU, GPU and FPGA implementations, spanning SISD, SIMD, and MISD parallelization regimes. We find exceptional speed-ups are possible with GPUs; however, we also find that FPGAs – and MISD configurations in general – remain competitive in a number of domains, particularly when power and space considerations outweigh price.
What functional aspects explain patients' impression of change after rehabilitation for long-lasting low back pain?

BACKGROUND Physical tests and self-report measures are being used to measure physical functioning. The latter tends to be preferred in intervention studies. PURPOSE To examine whether the patients' global impression of change (PGIC) after rehabilitation was explained by change in pain, daily functioning, fear-avoidance of activities and various physical aspects, expecting contribution primarily by the self-reported measures. METHODS A test-retest design, within a prospective cohort study of patients with long-lasting low back pain. 96 patients were consecutively recruited from an outpatient spine clinic, assessed by three self-report questionnaires and seven physical tests at inclusion and after 3.5 weeks of multidisciplinary treatment. With PGIC as the dependent variable, linear regression analyses of all variables were performed. The study was approved by the Regional Committee for Medical Research Ethics and the National Data Inspectorate of Norway. RESULTS In unadjusted analysis, change in pain, daily functioning and change in six physical tests contributed to the explained variance (R2: 6-24%). In the adjusted analysis, only pain and back endurance strength contributed (adjusted R2: 48%). In the final backward stepwise blockwise analyses, daily functioning and spinal mobility were also found to contribute to the explained variance (R2: 48%). The time span of 3.5 weeks of training is too short to give a lasting effect, but the contribution to explained variance of PGIC of self-report measures and physical tests were the focus of this study, not the effect of training. CONCLUSION Most measures demonstrated change that was of significance to the patients after rehabilitation. Change in spinal mobility and back strength assessed by physical tests contributed to explain the patients' impression of change after controlling for change in pain and daily life functioning and may seem important to assess in addition to the self-report measures in intervention studies.
Investigation of the relationship between drinking water quality based on content of inorganic components and landform classes using fuzzy AHP ( case study : south of Firozabad , west of Fars province , Iran )

In this study, the fuzzy analytic hierarchy process (AHP) is used to study the relationship between drinking water quality based on content of inorganic components and landform classes in the south of Firozabad, west of Fars province, Iran. For determination of drinking water quality based on content of inorganic components, parameters of calcium (Ca), chlorine (Cl), magnesium (Mg), thorium (TH), sodium (Na), electrical conductivity (EC), sulfate (SO4), and total dissolved solids (TDS) were used. It was found that 8.29 % of the study area has low water quality; 64.01 %, moderate; 23.33 %, high; and 4.38 %, very high. Areas with suitable drinking water quality based on content of inorganic components are located in parts of the south-eastern and south-western parts of the study area. The relationship between landform class and drinking water quality based on content of inorganic components shows that drinking water quality based on content of inorganic components is high in the stream, valleys, upland drainages, and local ridge classes, and low in the plain small and midslope classes. In fact we can predict water quality using extraction of landform classes from a digital elevation model (DEM) by the Topographic Position Index (TPI) method, so that streams, valleys, upland drainages, and local ridge classes have more water quality than the other classes. In the study we determined that without measurement of water sample characteristics, we can determine water quality by landform classes.
The relative biological effectiveness of fast neutrons for intestinal damage.

Abstract Relative biological effectiveness (RBE) of fast neutrons from the Medical Research Council cyclotron are compared to 250 kVp x rays for intestinal damage. The RBE is higher at low doses and approaches a common value of 1.9 at neutron doses above 1,000 rads. This RBE curve for intestinal damage is compared with similar curves for skin damage, damage to growing cartilage, and damage to hematopoietic tissues. All curves show the same general relationship between RBE and dose but differ in absolute RBE value from tissue to tissue. Clearly, extrapolations of RBE value from one tissue to another are unjustifiable.
Rail-to-Rail-Input Dual-Radio 64-Channel Closed-Loop Neurostimulator

A 64-channel 0.13-<inline-formula> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula> CMOS system on a chip (SoC) for neuroelectrical monitoring and responsive neurostimulation is presented. The <inline-formula> <tex-math notation="LaTeX">$\Delta \Sigma $ </tex-math></inline-formula>-based neural channel records signals with rail-to-rail dc offset at the input without any area-intensive dc-removing passive components, which leads to a compact 0.013-mm<sup>2</sup> integration area of recording and stimulation circuits. The channel consumes 630 nW, yields a signal to noise and distortion ratio of 72.2 dB, a 1.13-<inline-formula> <tex-math notation="LaTeX">$\mu $ </tex-math></inline-formula>Vrms integrated input-referred noise over 0.1–500 Hz frequency range, and a noise efficiency factor of 2.86. Analog multipliers are implemented in each channel with minimum additional area cost by reusing the multi-bit current-digital to analog converter that is originally placed for current-mode stimulation. The multipliers are used for compact implementation of bandpass finite impulse response filters, as well as voltage gain scaling. A tri-core low-power DSP conducts phase-synchrony-based neurophysiological event detection and triggers a subset of 64 programmable arbitrary-waveform current-mode stimulators for subsequent neuromodulation. Two ultra-wideband (UWB) wireless transmitters communicate to receivers located at 10 cm to 2 m distance from the implanted SoC with data rates of 10–46 Mb/s, respectively. An inductive link that operates at 1.5 MHz provides power to the SoC and is also used to communicate commands to an on-chip ASK receiver. The chip occupies 6 mm<sup>2</sup> while consuming 1.07 and 5.44 mW with delay-based and voltage controlled oscillator-based UWB transmitters, respectively. The SoC is validated in <italic>vivo</italic> using epilepsy monitoring (seizure detection) and treatment (seizure suppression) experiments.
Memory for true and false autobiographical event descriptions

This study examined how participants respond to different types of false autobiographical event descriptions. Three attributes of autobiographical events (participant, location, and activity) were systematically altered to create different forms of false event description and these were examined, along with true events, to see if participants were more or less likely to rate the experience as remembered. The event attributes manipulated within false events systematically influenced the participant's memory ratings, and completely false events were the least likely to be identified as false. Mechanisms associated with access to autobiographical memory knowledge bases by which event attributes might cue an event as true or false are discussed.
150 $^{\circ}$ C Amorphous Silicon Thin Film Transistors With Low-Stress Nitride on Transparent Plastic

This paper reports on hydrogenated amorphous silicon (a-Si:H) thin-film transistors (TFTs) processed at 150°C using plasma-enhanced chemical vapor deposition on polyethylene naphthalate (PEN) transparent plastic substrates. We examine the impact of RF deposition power on film stress of amorphous silicon nitride (a-SiNx:H), and resulting TFT performance. Transistors with the lowest stress nitride, yield the best performance in terms of device mobility (~1.1 cm2/V·s), ON/OFF current ratio (~1010) , and gate leakage current (<; 0.1 pA). Stable TFTs are demonstrated with a threshold voltage shift of less than 0.8 V following 10 hours of DC bias stress at 10 V.
Validation of Recursive Logic in Graphic Design

Recursive Object Model (ROM)—as a conceptual tool based on the core idea of recursive logic—is applied to a process of graphic design to express an idea from a selected verse in the Bible. It demonstrates that ROM can lead a graphic design process to be more orderly, precise, and valid. Simultaneously, it suggests that a logic process of graphic design is a recursive logic process. Not only does recursive logic exist in the process of graphic design, but also is graphic design logic.
The influence of perceived discrimination, sense of control, self-esteem and multiple discrepancies on the mental health and subjective well-being in Serbian immigrants in Canada

The study focuses on the mental health and subjective well-being (SWB) of Serbian immigrants of the first generation in Canada. We wanted to examine if perceived discrimination, sense of control, self-esteem and perceived multiple discrepancy affect their mental health and SWB. Our results indicate that self-esteem and sense of control have a positive effect on mental health and all aspects of the SWB, while the perceived discrimination and perceived multiple discrepancy negatively affect SWB and mental health. Self-esteem was the most salient predictor of mental health, while the perceived multiple discrepancy was the most salient predictor of life satisfaction of Serbian immigrants.
Routes to Dissipation in the Ocean : The 2 D / 3 D Turbulence Conundrum

Turbulence research has reached a mature stage, even though at the most fundamental level turbulence itself remains a mystery. The phenomenology and physical mechanisms of the separate regimes of twoand threedimensional, geostrophic, stratified, gravity-wave, and boundary-layer turbulence are all now fairly completely established. They describe well the nature of geophysical turbulence at various space and time scales and at various locations. However, an unsolved fundamental problem remains: how do these different regimes of turbulence coexist and connect in the ocean? How and where does the energy of the general circulation cascade from the large climatic scales, where most of it is generated, to the small scales, where all of it is dissipated? In particular, how is the dynamical transition made from an anisotropic, 2D-like, geostrophic cascade at large scales—with its strong inhibition of down-scale energy flux—to the more isotropic, 3D-like, down-scale cascades at small scales. This essay discusses these problems, highlighting the physical laws that prevent a simple down-scale energy cascade and the possible connections among the different regimes of geophysical turbulence.
BPTES inhibition of hGA124–551, a truncated form of human kidney-type glutaminase

The initial transcript of the GLS1 gene undergoes alternative splicing to produce two glutaminase variants (KGA and GAC) that contain unique C-terminal sequences. A truncated form of human glutaminase (hGA124–551) that lacks either C-terminal sequence was expressed in E.Coli and purified. This construct exhibits a hyperbolic glutamine saturation profile (Km of 1.6 mM). BPTES, bis-2[5-phenylacetamido-1,2,4-thiadiazol-2-yl]ethylsulfide, functions as a potent uncompetitive inhibitor of this construct (Ki of 0.2 µM). The hGA124–551 is inactive in the absence of phosphate, but exhibits a hyperbolic phosphate-dependent activation profile that is also inhibited by BPTES. Gel filtration studies indicate that hGA124–551 forms a dimer in the absence or presence of 100 mM phosphate, whereas addition of BPTES causes the formation of an inactive tetramer. The combined data indicate that BPTES inhibits human glutaminase by a novel mechanism and that BPTES is a potential lead compound for development of an effective cancer chemotherapeutic agent.
PRIMARY FIBROBLAST CELL CULTURES FROM TRANSBRONCHIAL BIOPSIES OF LUNG TRANSPLANT RECIPIENTS1

Background. Survival after lung transplantation is limited by the development of bronchiolitis obliterans (BO) that is a fibroproliferative process and regarded as the histological marker of chronic rejection. To study further the pathogenesis of BO we attempted to establish primary fibroblast cell cultures from transbronchial lung biopsies (TBBs)of lung transplant recipients. Methods. One to two TBB samples from each patient were collected in sterile phosphate-buffered saline. Biopsies were cut into small pieces and placed onto 25-cm2 culture flasks for cell culture and kept under standard cell culture conditions (21% O2, 5% CO2, 37°C). Culture medium consisted of RPMI 1640, 10% fetal calf serum, L-glutamine, HEPES, and antibiotics. After reaching confluence, fibroblasts were passaged into 75-cm2 flasks. Results. The success rate of establishing fibroblast cultures from transbronchial lung biopsies was 54% (27/50). Cell growth was independent of patient age, transplant type, underlying lung disease, indication for transbronchial lung biopsies, grade, or type of rejection and infection. Conclusions. We have established a novel method of culturing fibroblasts from lung transplant recipients. We consider this method as an unique human in vitro model to study the pathogenetic mechanisms leading to BO.
Evaluation of temperature sensitivity of human papillomavirus type 11 by using the human xenograft severe combined immunodeficiency mouse model

The temperature sensitivity of human papillomavirus type 11 was evaluated by using a human xenograft severe combined immunodeficiency mouse model. Incubation of the virus for 1 h at a temperature higher than 56 degrees C but lower than 72 degrees C was sufficient to inhibit the virally induced growth of infected human tissue. However, 100 degrees C was necessary to completely inactivate HPV type 11 genome expression.
Measurement of breathing characteristic in mouse during inhaling drug

We measured breathing at the air passage in mice, in which a high humidity drug was introduced into the air passage by a nebulizer to evaluate airway contraction. To lengthen the lifetime of a catheter flow sensor in such a humid environment, a combination of silicone oil and a parylene film coating was newly conducted in the packaging process. The developed sensor was inserted into an air passage in mouse, and then a drug which caused the air passage to contract was given to the mouse. The sensor directly detected the breathing characteristics.