Miracle-dz/UniFAR-FTUs huggingface dataset:
Impacted teeth “ kissing molars " : systematic review Dentes impactados " kissing molars " : revisão sistemática Impactan dientes " kissing molars " : revisión sistemática

Background: The purpose of this systematic review was to gather more information on impacted teeth called "kissing molars", and their treatment, allowing the oral surgeon to guide the clinical resolution. Methods: An electronic survey was conducted in five databases and manual search, in accordance with the Guidelines for Preferred Reporting Items for Systematic Reviews (PRISMA). The inclusion criteria were studies in which at least one patient was diagnosed with "kissing molars"; published in English, since 2000. Results: Fifteen studies were included for the analysis, totaling 37 patients evaluated, being 21% (8) bilateral cases, 54% (20) unilateral cases and 24% (9) cases were not specified. In 40% (15) patients presented some symptoms that led to the diagnosis. The treatment performed in most cases was dental extraction 89% (33 patients) with post-operative complications in 8% of the cases. Conclusion: The findings of this systematic review suggest a complement in the classification and standardization of this clinical condition, to help in the planning and treatment.
Polypropylene-Grafted Poly(hexamethylene guanidine)/Modified Polyethylene Monofilament and Its Antimicrobial Performance

A polypropylene-grafted poly(hexamethylene guanidine) (PP-g-PHMG)/polyethylene (PE) monofilament was prepared by melt blending and spinning using PE and PP-g-PHMG. The effect of PP-g-PHMG content on the structure, mechanical properties, and antimicrobial properties of PP-g-PHMG/PE alloy monofilaments was studied. Compared with PP/PE without grafting PHMG, of PP-g-PHMG/PE alloy monofilaments increased due to rigidity of PHMG grafted. In the PP-g-PHMG/PE alloy monofilaments, the total degree of crystallinity of alloy monofilaments decreased; hence, the - relaxation associated with the crystalline region of the polymer matrix becomes weaker as PP-g-PHMG content increases. The breaking strength of PP-g-PHMG/PE alloy monofilaments decreased while the knotting strength increased by increasing PP-g-PHMG content. The antibacterial test showed that the PP-g-PHMG/PE alloy monofilament had obvious inhibitory effect on E. coli and Staphylococcus aureus. Therefore, the PP-g-PHMG/PE alloy monofilament has the potential to make green and highly effective antifouling materials.
Research Online Research

Public-sector organisations face several challenges in their efforts to attain business-IT alignment. Strategic alignment is considered an important construct in the study of business value related to IT projects. This aim of this study is to identify the main factors contributing to business value in IT projects in public-sector organisations in Saudi Arabia (SA) by applying a business/IT strategy alignment perspective. This research utilises a qualitative study design that includes a sample of 15 executives, senior managers and other employees from five case study public-sector organisations. These organisations are all implementing a digital transformation plan in Saudi Arabia, a growing economy aiming at modern digitisation. Qualitative data were analysed using NVivo 12 software. The key findings of the study indicate that top management characteristics, IT governance mechanisms, business and IT strategy alignment and the implementation of IT project planning and quality can benefit organisational performance, services innovation, and operational excellence.
Acoustic Source Localization and High Quality Beamforming Using Coincident Microphone Arrays

This paper presents an application-oriented approach to Acoustic Source Localization using a coincident microphone array. Multiple processing blocks are presented to generate a reactive, yet stable Direction of Arrival estimation tuned toward speaker tracking. Building on an energy based scanning method, individual characteristics, such as sound field directivity and static sound source positions are used for adaptive smoothing of the detected angle. The methods and resulting performance gain are discussed for the individual components of the algorithm. Objective performance is evaluated using simulated and recorded data. Audio quality is assessed using listening tests, which show a significant increase in subjective sound quality, noise suppression, and speech intelligibility when combining the tracker with a beamforming algorithm for coincident microphone arrays.
A Novel Approach Of Obtaining Optimal Solution For Iterative Self-Consistent Parallel Imaging Reconstruction

As Magnetic Resonance Imaging (MRI) is gaining popularity in the field of medical science, there are many ongoing researches to increase it’s accuracy and efficiency. In this work, the focus has been given to an already established parallel MRI reconstruction method named Iterative SelfConsistent Parallel Imaging Reconstruction: SPIRiT. SPIRiT uses coil-by-coil parallel reconstruction method and then applies sum-of-square (SOS) to produce the final MR image. The SOS recombination technique proved to be amplifying noise as well as it based on the assumption that parallel coil sensitivities are uniform. In this paper a convex optimization scheme has been implemented which not only can overcome the shortcomings of SOS recombination technique but also can provide a true optimal solution for SPIRiT. The SOS recombination of original SPIRiT has been replaced by a convex optimization formula and hen the upgraded SPIRiT method has been compared with original SPIRiT for proposed method’s legitimacy. It has also been shown that this research also has impacts on the scanning time. The comparison results cover the aspects of qualitative, quantitative and noise-based analysis to illustrate the efficiency of the proposed formula.
Adopting Occupational Health and Safety Management Standards: The Impact on Financial Performance in Pharmaceutical Firms in China

Background and Purpose In recent years, the frequent occurrence of occupational accidents, illness, and injuries has become a major issue in China. This study aims to investigate the relationship between the adoption of Occupational Health and Safety Management System (OHSMS) standards and financial performance, with a particular focus on the pharmaceutical firms in China. Methods The study is based on a sample consisting of 125 pharmaceutical firms listed on the Shanghai and the Shenzhen stock exchanges in China for the period 2010–2018. Each sample firm was evaluated by whether and when it is certified by an OHSMS standard depending on secondary data collected from an independent certification database. Panel-based regression models were employed to explore whether adoption of an OHSMS standard has had an impact on financial performance. Results The regression results reveal that the adoption of an OHSMS standard positively affects contemporaneous financial performance measured by return on assets (ROA), return on equity (ROE), and earnings per share (EPS). Mixed results were found when financial performance indicators were extended by two years, suggesting that ROE will increase in the second year after a firm is certified with the standard, but EPS will decline in the third year. Conclusion The study findings empirically show that adoption of an OHSMS standard contributes to better financial performance for pharmaceutical firms of China in the short term. However, executives of pharmaceutical firms need to be aware of the increased costs related to certification renewal and audit in the following periods and exercise their management discretion to achieve a win–win situation between OHSMS implementation and financial benefit.
Cost-Effectiveness Analysis of Colorectal Cancer Screening: A Systematic Review

Introduction Colorectal cancer (CRC) is a significant health problem with an increasing incidence worldwide. Screening is one of the ways, in which cases and deaths of CRC can be prevented. The objective of this systematic review was to evaluate the cost-effectiveness of the different CRC screening techniques and to specify the efficient technique from a cost-effectiveness perspective. Methods The economic studies of CRC screening in general populations (average risk), aged 50 years and above were reviewed. Two reviewers independently reviewed the titles, abstracts, and full-texts of the studies in five databases: Cochrane, Embase, Scopus, Web of Science and PubMed. The disagreements between reviewers were resolved through the authors’ consensus. The main outcome measures in this systematic review were the incremental cost-effectiveness ratio (ICER) of screening versus no-screening and then in comparison with other screening techniques. The ICER is defined by the difference in cost between two possible interventions, divided by the difference in their effect. Results Eight studies were identified and retained for the final analysis. In this study, when screening techniques were compared to no-screening, all CRC screening techniques showed to be cost-effective. The lowest ICER calculated was $PPP −16265/quality-adjusted life-year (QALY) (the negative ICERs were between purchasing power parity in US dollar ($PPP) −16265/QALY to $PPP −1988/QALY, whereas the positive ICERs were between $PPP 1257/QALY to $PPP 55987/QALY). For studies comparing various screening techniques, there was great heterogeneity in terms of the structures of the analyses, leading to diverse conclusions about their incremental cost-effectiveness. Conclusion All CRC screening techniques were cost-effective, compared with the no-screening methods. The cost-effectiveness of the various screening techniques mainly was dependent on the context-specific parameters and highly affected by the framework of the cost-effectiveness analysis. In order to make the studies comparable, it is important to adopt a reference-based methodology for economic evaluation studies.
Atrial Myopathy Underlying Atrial Fibrillation

While AF most often occurs in the setting of atrial disease, current assessment and treatment of patients with AF does not focus on the extent of the atrial myopathy that serves as the substrate for this arrhythmia. Atrial myopathy, in particular atrial fibrosis, may initiate a vicious cycle in which atrial myopathy leads to AF, which in turn leads to a worsening myopathy. Various techniques, including ECG, plasma biomarkers, electroanatomical voltage mapping, echocardiography, and cardiac MRI, can help to identify and quantify aspects of the atrial myopathy. Current therapies, such as catheter ablation, do not directly address the underlying atrial myopathy. There is emerging research showing that by targeting this myopathy we can help decrease the occurrence and burden of AF.
Understanding the people’s willingness to change their intensions towards bicycle

Bicycles are the easiest and cheapest form of mode of transport which can be used to reduce pollution and other environmental negative externalities. Recently, with the awareness of its benefits, many cities around the world have successfully adopted bicycles in form of sharing scheme and inspired by this, Gandhinagar, the administrative capital of Gujarat also took initiatives to introduce Bike share Program. The planned city of Gandhinagar, compared to the other cities are endowed with a better bicycle-friendly environment with wide congestion free roads and surplus tree coverage, but yet saw a decline in the use of bicycles from the stands. Hence it becomes necessary to know the factors that stimulate individual to use (or not to use) the bicycles. As to modify the travel patterns, it is necessary to under- stand in detail the behavior of individuals and the reasons why they choose (or do not chose) a particular mode of transport. The aim of the present study was to understand the difference in the factors which determines people’s willingness to adopt bicycling in Gandhinagar. In order to recognize these factors, use of Theory of Reasoned Action (TRA) components and the concept of transtheoretical model of change (TTM) were used. The study included a sample of 147 people drawn from the general public who already knew how to bicycle, traveled frequently every day and lived in the precincts of Gandhinagar. The results to an extent confirmed that the constructs, as measured by the TRA, only distinguished difference between Precontemplation, Contemplation, and Maintainers successfully, with exception of Active group which overall failed to form a linear relationship between all the stages. But in overall, the aggregate values of attitude are very low in all the stages with very small variations between them. Especially in case of their perceived benefits and the barriers, Majority of people agreed that cycling is good for their health and that it is an environmentally sound way to commute and similarly was observed in there perceived barriers especially the climatic related barriers. What differentiated them were the aspects of their personal and social norms, flexibility and their intentions which became more positive with advancing stages except the group who were already using bicycles in their daily basis (Active). The study also discussed about the short-term benefits of flexibility, which showed a very strong relationship with the process of change, and how the negative barriers has to be addressed and taken seriously if we wanted to persist a change in their decision to change. Implications of the current findings about the description of different characteristics which evolved out from the constructs were discussed in detail and ending the paper with plausible recommendation.
Metabolic Syndrome Predicts Poor Outcome in Acute Ischemic Stroke Patients After Endovascular Thrombectomy

Background and Aims The metabolic syndrome (MetS) is believed to contribute to a higher probability of developing cardiovascular diseases. This study aimed to investigate whether MetS could predict the prognosis in ischemic stroke patients after endovascular thrombectomy (EVT). Methods Between January 2016 and September 2019, patients treated with EVT due to large vessel occlusions in anterior circulation were prospectively recruited. MetS was defined using the International Diabetes Federation criteria after admission. The primary outcome was a 3-month poor outcome (modified Rankin scale score of 3–6). Secondary outcomes included symptomatic intracranial hemorrhage (sICH) and mortality at 3 months. Multivariable logistic regression models were used to assess the relationship between MetS and clinical outcomes. Results A total of 248 patients were enrolled (mean age, 66.7 years; 37.5% female) and 114 (46.0%) met with the MetS criteria. The median National Institutes of Health Stroke Scale score was 15.0. There were 131 (52.8%) patients achieving the poor outcome at 3 months, among which 26 (10.5%) patients developed sICH. The mortality at 3 months was 19.0% (47/248). In multivariable analysis, MetS was significantly correlated to poor outcome (odds ratio [OR], 2.48; 95% confidence interval [CI], 1.29–4.78, P = 0.014). The risk for poor outcome was positively associated with the increased number of MetS components (OR 1.78; 95% CI 1.39–2.35, P = 0.001). No significant findings were found in the association of MetS with sICH and mortality. Conclusion Our data demonstrated that MetS was associated with poor prognosis in acute ischemic patients treated with EVT.
RGD- and VEGF-Mimetic Peptide Epitope-Functionalized Self-Assembling Peptide Hydrogels Promote Dentin-Pulp Complex Regeneration

Introduction Cell-based tissue engineering is a promising method for dentin-pulp complex (DPC) regeneration. The challenges associated with DPC regeneration include the generation of a suitable microenvironment that facilitates the complete odontogenic differentiation of dental pulp stem cells (DPSCs) and the rapid induction of angiogenesis. Thus, the survival and subsequent differentiation of DPSCs are limited. Extracellular matrix (ECM)-like biomimetic hydrogels composed of self-assembling peptides (SAPs) were developed to provide an appropriate microenvironment for DPSCs. For functional DPC regeneration, the most important considerations are to provide an environment that promotes the adequate attachment of DPSCs and rapid vascularization of the regenerating pulp. Morphogenic signals in the form of growth factors (GFs) have been incorporated into SAPs to promote productive DPSC behaviors. However, the use of GFs has several drawbacks. We envision using a scaffold with SAPs coupled with long-term factors to increase DPSC attachment and vascularization as a method to address this challenge. Methods In this study, we developed synthetic material for an SAP-based scaffold with RGD- and vascular endothelial growth factor (VEGF)-mimetic peptide epitopes with the dual functions of dentin and pulp regeneration. DPSCs and human umbilical vein endothelial cells (HUVECs) were used to evaluate the biological effects of SAP-based scaffolds. Furthermore, the pulpotomized molar rat model was employed to test the reparative and regenerative effects of SAP-based scaffolds. Results This scaffold simultaneously presented RGD- and VEGF-mimetic peptide epitopes and provided a 3D microenvironment for DPSCs. DPSCs grown on this composite scaffold exhibited significantly improved survival and angiogenic and odontogenic differentiation in the multifunctionalized group in vitro. Histological and functional evaluations of a partially pulpotomized rat model revealed that the multifunctionalized scaffold was superior to other options with respect to stimulating pulp recovery and dentin regeneration in vivo. Conclusion Based on our data obtained with the functionalized SAP scaffold, a 3D microenvironment that supports stem cell adhesion and angiogenesis was generated that has great potential for dental pulp tissue engineering and regeneration.
Trapping and chemical control of Ceratitis capitata (Wied.) (Diptera: Tephritidae) on sweet orange (Citrus sinensis) in Nigeria

SummaryBaited attractant traps consisting of cotton-wool soaked with 10% honey + 10% sugar + 0.025 g a.i. deltamethrin inside a yellow container were used to capture Ceratitis capitata on four sweet orange cultivars and tangelo in the field. Although the local cv Agege 1 was most heavily infested, it showed the least level of damage by C. capitata, compared with the others. Endosulfan, applied at 700 g ha−1 a.i. was the most effective of three insecticides tested for control. A combination of baited traps and insecticide sprays is suggested for the control of C. capitata on citrus in Nigeria.
Downregulation of circRNA_0000285 Suppresses Cervical Cancer Development by Regulating miR197-3p–ELK1 Axis

Background Circular RNAs (circRNAs) are involved in the development of human cancers, including cervical cancer (CC). However, the role and mechanism of the circRNA hsa_circ_0000285 (circ_0000285) in CC development remain largely unknown. Methods Thirty paired CC and adjacent normal tissue samples were harvested. CC cell lines SiHa and HeLa were cultured in this study. The expression of circ_0000285, miR197-3p and ELK1 was detected via qRT-PCR or Western blot. CC development was assessed via cell viability, colony formation, apoptosis, cell cycle, and autophagy using MTT, colony-formation assays, flow cytometry and Western blot. The target association was analyzed via dual luciferase–reporter assay, RNA immunoprecipitation, and RNA pull-down. The role of circ_0000285 in CC in vivo was analyzed using a xenograft model. Results circ_0000285 abundance was enhanced in CC tissue and cells and mainly located in cytoplasm. Silence of circ_0000285 suppressed cell viability and colony formation, arrested the cell cycle at the G0/G1 phase, and induced apoptosis and autophagy in CC cells. miR197-3p was targeted by circ_0000285, and miR197-3p knockdown reversed the effect of circ_0000285 silence on CC development. miR197-3p directly targeted ELK1 to inhibit CC development. circ_0000285 regulated ELK1 by modulating miR197-3p. Knockdown of circ_0000285 reduced xenograft tumor growth in vivo. Conclusion Knockdown of circ_0000285 repressed CC development by increasing miR197-3p and decreasing ELK1.
Randomized Study Comparing Vildagliptin vs Glibenclamide on Glucose Variability and Endothelial Function in Patients with Type 2 Diabetes Mellitus and Hypertension

Background Glucose variability (GV) is considered an important factor for cardiovascular disease (CVD) in patients with type 2 diabetes mellitus (T2DM). High GV causes endothelial dysfunction and increased oxidative stress. Dipeptidyl peptidase-4 (DPP-4) inhibitors may improve endothelial function and decrease GV. The aim of this study was to investigate the effects of vildagliptin, a DPP-4 inhibitor, compared with glibenclamide in GV and endothelial function in patients with T2DM and arterial hypertension. Methods This is a prospective, randomized, open and drug-controlled study. Fifty patients older than 35 years with T2DM and hypertension without CVD were randomized to receive vildagliptin (n=25) or glibenclamide (n=25), both in added-on metformin. Laboratory tests and analysis of endothelial function were performed before and 12 weeks after treatment. Endothelial function, defined by reactive hyperemia index (RHI), was analyzed by peripheral artery tonometry (endo-PAT2000). GV was evaluated by capillary glucose with intermittent monitoring device, six measurements per day, for three days, before and after treatment. The median of standard deviation (SD) of mean blood glucose (MBG) was used to evaluate GV. Results GV decreased in the vildagliptin group (35.2 to 30.7, P=0.037) but did not change with glibenclamide (37.6 to 37.5, P=0.765). Glycated hemoglobin was similar in both groups. MBG decreased only in glibenclamide group, without difference with vildagliptin group (P=0.374). There were no changes in the RHI in both groups and there was no correlation between GV and RHI (P=0.658). Conclusion Vildagliptin reduces GV; however, the action on endothelial function was not demonstrated. In addition, there was no correlation between GV and endothelial function.