Miracle-dz/UniFAR-FTUs huggingface dataset:
SponGES POLICY BRIEF The ecological value of deep-sea sponges

SponGES has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 679849. This document reflects only the author’s view – the Executive Agency for Small and Medium-sized Enterprises is not responsible for any use that may be made of the information it contains. The ecological value of deep-sea sponges The ecological value of deep-sea sponges is determined by sponges’ specific ecological features and the role that sponge grounds play in the deep sea. Research on sponges in the deep sea is technologically complex and deeply weaved into microbiology, ecology, evolution, taxonomy, genetics, molecular biology and biotechnology. In December 2020, at the end of the four-year EU-funded SponGES project, the current ecological knowledge on deep-sea sponges was condensed into a list of main ecological features. These ecological features are simple statements describing, in qualitative terms, experts’ knowledge on deep-sea sponges.
Processing and nanoindentation and nanoscratch testing of alumina-coated YTZP

In this work, alumina-coated YTZP materials are proposed as means to combine the mechanical reliability of YTZP with the stiffness and hardness of alumina. Additionally, compressive stresses are developed in the alumina coating when cooling from the sintering temperature due to the thermal expansion mismatch between alumina and YTZP. The proposed processing method involves dipping of pre-sintered YTZP specimens in stable alumina suspensions and co-sintering of the dipped specimens. The inﬂuence of the processing parameters on the macro and microstructure of the materials has been estab-lished. Berkovich indentation has been performed to determine the Young’s modulus of the substrates and coatings. The structural integrity of the coatings has been analysed using scratch tests. The Young’s modulus. The optimised specimens
A Strategy to Enhance Energy Efficiency for EC-MRPL in Internet of Mobile Things

________________________________ Abstract - Decentralized type of network is used in internet of things environment, in which nodes communicate with each other and data is transferred to the internet via base station. The communication routing is applied using RPL (IPV6 Routing Protocol for Low Power and Lossy Network) in IoT. It is systematic routing protocol for LLNs (Low Power and Lossy Network). To ensure the mobility in RPL, MRPL (mRPL: Boosting mobility in the Internet of Things) is introduced. Energy consumption is one of the important criteria for mobile nodes because they are battery-powered. So, EC-MRPL (EC-MRPL: An energy-efficient and mobility support routing protocol for the Internet of Mobile Things), an enhancement of MRPL is introduced to improve the energy efficiency in MRPL. In this paper we proposed novel strategy to enhance the energy efficiency and network performance in EC-MRPL and MRPL. A cluster based approach is proposed to handle the traffic and energy consumption efficiently. Our proposed approach is implemented in ns-2 (Network Simulator Version 2) and our experimental results depict that the proposed approach is more energy efficient and has better performance in terms of delay and throughput with compared to MRPL protocol.
The acceptance of smart solutions on desalination plants

By 2025 at least half of the world’s population will be living in water-stressed areas. Desalination, the process of the removal of salts and minerals from a target substance, is one of the solutions to counter freshwater scarcity. There are approximately 12500 desalination plants worldwide. But these plants are costly, both to build and to operate. Industry 4.0 offers new solutions to bring down costs and energy usage. But giving existing desalination plants a “smart” makeover is also costly. Thus, the purpose of this paper is to investigate the technology acceptance of smart desalination plants within water critical areas. An extended version of the technological acceptance (TAM) model with new variables is proposed. These variables are partly tested through two different types of data collection; interviews and surveys. More research is needed to validate the complete model. This paper contains the basis needed in order to conduct further research.
GENETIC CHARACTERIZATION OF VARIANT INFECTIOUS BRONCHITIS VIRUSES DETECTED IN BROILER CHICKENS IN SOUTH EGYPT

Avian Infectious bronchitis virus (IBV), a major pathogen of commercial poultry flocks, circulates in the form of multiple ever emerging variants threatening the poultry industry. This study was conducted to survey the presence of IBV from Luxor Governorate during 2015 -2016. Examination of 43 pooled samples including trachea and kidney homogenates by real time RT- PCR for N gene, revealed 35 (81.4%) out of 43 commercial broiler flocks were positive to IBV. The 400-bp of HVR3 of the S1 gene of ten selected samples were amplified by RT-PCR, sequenced, and aligned for phylogenetic and amino-acid similarity analyses. The ten IBV viruses share from 71% to 90.8% homologies between each other but are very different from the vaccinal strains (H120, MA5, M48, 4/91 and CR88) used in Egypt with 62.6 to 84.7 % similarities. Phylogenetic analysis revealed that all the Luxor detected viruses were grouped within the Variant 2 IBV cluster together with the D1456-like Egyptian IBVs but in a different subcluster. Monitoring the emerging IBV variants is extremely important for establishing an effective control strategy for the disease in Luxor and surrounding area. sequences of various strains.
A Streamlined Mobile User-Interface for Improved Access to LMS Services

— Universities in developing countries face greater challenges in implementing Learning Management Systems (LMSs) due to resource-poor settings, characterized by: low levels of ICT infrastructure; electricity outages; few computers; and limited and expensive Internet bandwidth, among other constraints. It is anticipated that if mobile phones are carefully integrated into the ecologies of LMSs, the impact of some of the above challenges in implementing LMSs would be reduced. This paper presents a user-centered design process of mobile LMS interfaces for accessing selected LMS services on mobile phones, and a user experience evaluation for a mobile LMS application implementation. From the design and implementation processes of the mLMS (mobile LMS), and the user experience evaluation of a working mLMS prototype, we conclude that: the ideas presented in the mLMS are technically feasible; the application is useful to the students and the students are encouraged to use their mobile phones to access LMS services more often, thereby reducing the over-reliance and pressure on the constrained institutional ICT resources.
oxysporum: An Efficient Tool for

a restriction site-associated DNA to characterize transfer-DNA insertions in (RAD-seq) to identify the position of transfer-DNA (T-DNA) insertions in the genome of Phomopsis longicolla , an important pathogen of soybean. The technique enables high- throughput characterization of mutants generated via Agrobacterium tumefaciens -mediated transformation (ATMT), thus accelerating gene discovery via forward genetics. This technique represents a significant advancement over existing approaches to characterize T-DNA insertions in fungal genomes. With minor modifications, this technique could be easily adapted to taxonomically diverse fungal pathogens and additional mutagenesis cassettes. ABSTRACT 38 Phomopsis longicolla (Hobbs) causes Phomopsis seed decay and stem lesions in soybean 39 ( Glycine max ). In this study, a novel, high-throughput adaptation of RAD-seq termed MoNSTR- 40 seq (Mutation analysis via Next-generation DNA Sequencing of T-DNA Regions) was 41 developed to determine the genomic location of T-DNA insertions in P. longicolla mutants. 42 Insertional mutants were created via ATMT, and one mutant, strain PL343, was further 43 investigated due to impaired stem lesion formation. MoNSTR-seq, in which DNA libraries are 44 created with two distinct restriction enzymes and customized adapters to simultaneously enrich 45 both T-DNA insertion borders, was developed to characterize the genomic lesion in strain 46 PL343. MoNSTR-seq successfully identified a T-DNA insertion in the predicted promoter 47 region of a gene encoding a cellobiose dehydrogenase ( CDH1 ), and the position of the T-DNA 48 insertion in strain PL343 was confirmed by Sanger sequencing. Thus, MoNSTR-seq represents 49 an effective tool for molecular genetics in P. longicolla , and is readily adaptable for use in 50 diverse fungal species. 51 52
Uncertainty limits the use of power analysis

The calculation of statistical power has been taken up as a simple yet informative tool to assist in designing an experiment, particularly in justifying sample size. A difficulty with using power for this purpose is that the classical power formula does not incorporate sources of uncertainty (e.g., sampling variability) that can impact the computed power value, leading to a false sense of precision and confidence in design choices. We use simulations to demonstrate the consequences of adding two common sources of uncertainty to the calculation of power. Sampling variability in the estimated effect size (Cohen's 𝑑 ) can introduce a large amount of uncertainty (e.g., sometimes producing rather flat distributions) in power and sample ‐ size determination. The addition of random fluctuations in the population effect size can cause values of its estimates to take on a sign opposite the population value, making calculated power values meaningless. These results suggest that calculated power values or use of such values to justify sample size add little to planning a study. As a result, researchers should put little confidence in power ‐ based choices when planning future studies.
Identity and Collaborative Strategy in the Case of Canadian HIV/AIDS Treatment ∗

We explore the links between identity and strategy making by drawing upon a case study of a collaborative strategy implemented by community organizations and pharmaceutical companies involved in Canadian HIV/AIDS treatment. In implementing collaborative strategy, our analysis shows that champions engage in identity work that simultaneously involves: (a) identification with their respective constituencies and, specifically, with categories associated with high legitimacy; (b) counter-identification from their respective constituencies by constructing themselves as different from its core members; (c) dis-identification away from their constituency towards their collaborative partners. We also examine the interactions between champions and other actors involved in the strategic change process to show the limits and tensions involved in such identity work. We conclude with a discussion of the implications for research and practice.
JCB_201607110 149..166

Mitochondrial function is critical for maintenance of local and systemic metabolic homeostasis. Preservation of normal mitochondrial function requires proteostasis, which is dynamically controlled by mitochondria-specific chaperones and proteases (Jensen and Jasper, 2014; Quirós et al., 2015). Mitochondrial proteotoxic stress, which is characterized by the accumulation of misfolded and unfolded proteins within mitochondrial compartments, activates a retrograde transcriptional response called the mitochondrial unfolded protein response (UPRmt). This adaptive response, which is aimed at reestablishing mitochondrial proteostasis, is conserved from worms to mammals. In multiple model organisms, genetic and pharmacological induction of the UPRmt exerts beneficial effects on lifespan, consistent with overall improvements in systemic metabolic homeostasis (Feng et al., 2001; Dillin et al., 2002; Durieux et al., 2011; Houtkooper et al., 2013; Owusu-Ansah et al., 2013). A recent study in Caenorhabditis elegans demonstrated that induction of the UPRmt promotes glycolytic metabolism, allowing subsequent recovery of mitochondrial function and oxidative phosphorylation; these results establish a precedent for the idea that UPRmt induction has metabolic consequences (Nargund et al., 2015). However, it remains to be determined whether induction of the UPRmt by genetic or pharmaceutical means exerts beneficial effects on systemic metabolic homeostasis in mammals. Moreover, in contrast to the situation in worm and fly, in mammals, the non–cell-autonomous signaling factors that Reduced mitochondrial electron transport chain activity promotes longevity and improves energy homeostasis via cell-autonomous and –non-autonomous factors in multiple model systems. This mitohormetic effect is thought to involve the mitochondrial unfolded protein response (UPRmt), an adaptive stress-response pathway activated by mitochondrial proteotoxic stress. Using mice with skeletal muscle–specific deficiency of Crif1 (muscle-specific knockout [MKO]), an integral protein of the large mitoribosomal subunit (39S), we identified growth differentiation factor 15 (GDF15) as a UPRmt-associated cell–non-autonomous myomitokine that regulates systemic energy homeostasis. MKO mice were protected against obesity and sensitized to insulin, an effect associated with elevated GDF15 secretion after UPRmt activation. In ob/ob mice, administration of recombinant GDF15 decreased body weight and improved insulin sensitivity, which was attributed to elevated oxidative metabolism and lipid mobilization in the liver, muscle, and adipose tissue. Thus, GDF15 is a potent mitohormetic signal that safeguards against the onset of obesity and insulin resistance. Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis
Mesoporous Bioactive Glass – Part 1: Processing and Application

According to the IUPAC definition, porous materials are divided into three classes: microporous (<2 nm), mesoporous (2–50 nm) and macroporous (>50 nm) [1]. Ordered mesoporous silica was first discovered in 1992 [2], and proposed as a drug delivery system in 2001 [3]. Since then silica-based glass microspheres, such as MCM-41, SBA-15 or MCM-48 type ordered mesoporous glass materials have been considered as an ideal material for incorporation of drugs, genes and other therapeutic agent carriers and control release systems. Mesoporous bioactive glasses can be prepared by sol-gel method, which is a wet-chemistry process for producing materials from building blocks such as the silicate tetrahedra, structural directive agents and metallic ions. This process mainly involves hydrolysis and condensation of precursors, drying, and stabilization. By controlling the processing parameters, the properties of the reaction product, such as its morphology and chemical and phase composition can be readily controlled. For the sol-gel synthesis of bioactive glasses, tetraethyl orthosilicate (TEOS) is the most widely used silicate precursor, while water and/or ethanol are used as solvents. The sol-gel process can take place under acidic or basic conditions, affecting the properties of the resulting materials: a simple changing of the pH of the solvent yields bioactive glasses with different morphology. In a typical sol-gel process used for preparation of bioactive glass nanoparticles, TEOS firstly undergoes hydrolysis and condensation in the presence of catalysts and structural directive agent to form SiO 2 nanoparticles. Metal ion precursors can be added during the hydrolysis and condensation above solution. Aqueous solution of ammonium hydroxide (28%) and 14.4 ml of tetraethyl orthosilicate (TEOS) were then added into the solution under continuous stirring. Finally, 10.15 g of calcium nitrate tetrahydrate was added, followed by magnetic stirring for 30 min. The solution was allowed to react for 4 h. After that, the suspension was filtrated and washed with deionized water and ethanol to remove unreacted precursors and remaining salts. The precipitates were dried in an oven at 40 °C overnight, followed by calcination at 650 °C (heating rate 1 °C/min) for 3 h. Fig. shows the SEM micrographs of nanoparticles obtained by the experiment. Both silica and bioglass particles with pineal shape, and with the mean equivalent diameter of 150 nm were prepared during the experiment. The particles do not form agglomerates. The EDX results confirm that the glass nanoparticles contain 5-7 Atomic % Ca. The high resolution SEM micrographs revealed fine surface structure of the nanoparticles indicating their lamelar mesoporous structure. However, for unambiguous confirmation specific surface area measurements and TEM analysis are required.
EXTRACT OF OLIVE ( OLEA EUROPAEA L. ) CURES HEMATOLOGIC TOXICOSIS INDUCED BY DOXORUBICIN

The protective effects of extract of Olea europaea L was evaluated in hematological toxicosis induced by Doxorubicin (DOX). Standard Soxhlet apparatus was used to prepare ethanolic extract of Olea europaea L leaves. Eighteen Wister rats (male) were incorporated in the study and divided in 3 groups: T* (control group: 2 ml 0.9 % Normal Saline), TP0 (DOX group: 15 mg/kg) and TP1 (extract of Olea europaea L + DOX: 200 + 15 mg/kg). The drugs were administered by intra peritoneal route. Blood was withdrawn on 57 th day by cardiac puncture and preserved for analysis. Hematological profile included CBC and Platelet count. Hematological analysis revealed that the animals which received Doxorubicin had low levels of Hemoglobin, RBCs, Leukocytes, Neutrophils, Eosinophils, Monocytes, Lymphocytes and Platelets when compared to control group which received normal saline. The levels of Hb and RBCs were low but not manifested in anemia. Neutrophil and Platelet count were drastically low, which shows positive sign of Neutropenia and Thrombocytopenia. The treated group animals which receive extract + DOX showed positive elevation in the levels of CBC and Platelet count. On the basis of hematological report it is concluded that combination of extract of Olea europaea L can prevent the toxicosis effects of Doxorubicin.
A Study On The Role Of Brand Ambassadors In Consumer Buying Behaviour Of Soft Drink

- Today ‘celebrity endorsement has fascinated enormous debate on whether it really contributes to the brand building process or whether it is just another lazy tool to make the brand more visible in the mind of consumers. Although it has been observed that the presence of a well-known personality helps in solving the problem of over communication that is becoming more prominent these days, there are few undesirable impacts of this practice on the brand. Firms invest huge amounts as advertising expenditure for hiring the right celebrity. Consumers perceive the brand as having superior quality because it has been endorsed by a credible source. The present paper tries to look behind the obvious benefits that whether the consumers buy the soft drinks just because it is endorsed by their favourite and well known personality or it is just needy that they have to buy the product or its just situation. And researcher has selected 300 respondents as a sample in Calicut city and all respondents’ falls under age between 18 to 50 years. Data have been collected from both the primary and secondary source. For the primary researcher has used questionnaire. Author has also formulated few hypotheses and used percentage analysis, correlation and arithmetic mean to find out the major findings. Finally researcher could able to found the reasons and influence of the brand ambassadors and their impact on consumers buying behaviour.
Attenuation of Acute GvHD in the Absence of the Transcription Factor ROR γ t

Graft-versus-host disease (GvHD) remains the most significant complication after allogeneic stem cell transplantation (allo-SCT). Previously, acute GvHD had been considered to be mediated predominantly by Th1 polarized T cells. Recently, investigators have identified a second proinflammatory lineage of T cells termed Th17 that is critically dependent on the transcription factor ROR γ t. Here, we have evaluated the role of Th17 cells in murine acute GvHD by infusing donor T cells lacking RORC and as a consequence the isoform ROR γ t. Recipients given donor CD4 + and CD8 + T cells lacking RORC had significantly attenuated acute GvHD and markedly decreased tissue pathology in the colon, liver, and lung. Using a clinically relevant haploidentical murine transplantation model, we showed that RORC −/− CD4 + T cells alone diminished the severity and lethality of aGvHD. This was not found when CD4 + T cells from RORC −/− mice were given to completely mismatched BALB/c mice, and correlated with absolute differences in the generation of TNF in the colon post transplant. Thus, CD4 + T cell expression of RORC is important in the pathogenesis of acute GVHD.
Triangular Mesh and Boundary Representation Combined Approach for 3D CAD Lightweight Representation for Collaborative Product Development

The lightweight representation of three-dimensional computer-aided design (3D CAD) models has drawn much attention from researchers as its usefulness in collaborative product development is vast. Existing approaches are mostly based on feature depression or mesh-based simplification. In this article, a new approach for 3D CAD lightweight representation based on combining triangular mesh representation and boundary representation (B-rep) is proposed. The corresponding data structure as well as the conversion method from original data given in B-rep was developed. Considered as an essential application in collaborative product development, a case study on the visualization process of large-scale assembly models represented in the proposed lightweight representation was also conducted. The validation of the approach was performed via experiments with 3D CAD models in SAT format and by benchmarking with the conventional all-faceted approach with the same level of mesh resolution.
Magnetic resonance imaging

Magnetic resonance (MR) plays a leading role in neurological imaging, providing optimal identi ﬁ cation of anatomic structures and also allowing the evaluation of functional and chemical aspects of both the central and peripheral nervous systems. These tools have increased the comprehension of different neurological disorders and improved the evaluation of treatment response to pharmacological or other therapeutic interventions. Moreover, several innovative MR techniques, such as functional magnetic resonance imaging (fMRI), MR spectroscopy (MRS) and diffusion-weighted imaging (DWI), have been shown to provide additional information, allowing a comprehensive evaluation in the identi ﬁ cation of a wide range of nervous system pathologies. However, body MRI may also be useful to depict several causes and manifestations of neurological pathologies, thus supporting a multidisciplinary diagnosis process. In this a brief discussion of MR basics will be presented, with particular attention on the aspects related to the evaluation of neurological disorders.
A Contingency Solution using Jet Grouting Barrier for a Dam under Risk of Piping in Brazil

During routine inspection works in 2006 inspectors found resurgences of water at the toe of a small embankment dam named “Ribeirão do Gama”, located at Brasília DF. After technical visits, geotechnical engineers characterized these groundwater leakages as a piping process at an early stage. Intervention only began in 2015 due to obstacles that occasionally happen in public works. In consequence, the piping problem worsened. A geotechnical consultancy was contracted to design a solution. After analysis of field conditions, the consultancy decided to build overlapping columns by the Jet Grouting method. This paper presents a case study of the project and works treatment, detailing its design, construction, and monitoring.