Miracle-dz/UniFAR-FTUs huggingface dataset:
Study of The Experimentally Zinc Deficiency in Iraqi Local Breed Goats

The current study was conducted to study the experimentaly induced zinc deficiency and its hematological consequences in Iraqi goats. Twenty five goats, 5-6 months old were involved in this study. The study extended from November 2018 and continued for 10 weeks in the farm of College of Veterinary Medicine, University of Diyala. The animals were fed a high calcium content ration (400-500 gm/head/day), in addition to hay and water with ad libitum during the study. The main clinical signs were retardation in hair growth, especially of legs and head, swollen joint, poor growth, rough hair coat, loss of hair on head, limbs, and scrotum, cracking of the hooves. The skin was rough, thickened, and cracked, alopecia, crusting, and hyperkeratosis also occurred. Paleness of the mucous membranes of the eye, loss of appetite, itching, and emaciation were observed. Body weight, heart rates, and body temperature were not significantly changed, while respiratory rates significantly decreased in the 3 and 6 weeks in comparison with the 1 week. The results of total red blood cells counts revealed significantly decrease in the 2 week compared with the 1 week, then increased in the 4, 6 and 8 weeks in comparison with the 1 week. Hemoglobin concentration significantly increased at the 2, 4 and 6th weeks in comparison with the 1 week. Packed cell volume increased at the 2, 4, 6 and 8 weeks compared with 1 week. Serum zinc was significantly decreased from the 2 week till the end of the experiment.Significant decrease in lymphocytes was detected at the 4 week compered with the 1, 2, 6 and 8 weeks. Eosinophil was also significantly decreased in the 2 and 6 weeks compared with the 1 week, and increased during the 4 week and 8 week compared with the 2 and 6 respectively. It is concluded from this study that zinc deficiency clearly affects the overall health status and may eventually lead to economic losses in local goats.
Development and psychometric evaluation of the Female Infertility Stigma Questionnaire: A mixed method study protocol

Background Infertility stigma is one of the greatest challenges in most societies for reproduction and sexual health of infertile women. Since no specific tool exists for assessing the infertility stigma in women, this study would be conducted to develop and evaluate the psychometric properties of Female Infertility Stigma Questionnaire (F-ISQ). Methods This is a mixed method study with sequential exploratory design (qualitative and quantitative phase). In the first qualitative phase, semi-structured interviews would be performed with infertile female who had experienced infertility whithout any psychological disorder. Women who are eligible for participating in the study will be selected using purposeful sampling method with maximum variation in terms of age, education, occupation and infertility duration. Data would be analyzed using conventional content analysis and in this phase the primary item pool will be developed for the Female Infertility Stigma Questionnaire (F-ISQ). In the quantitative phase, the psychometric properties of the questionnaire would be evaluated, including the content, face and construct validity as well as reliability via the internal consistency and stability. The psychometric properties described in the COSMIN checklist will be utilized for designing the instrument.Discussion Developing a valid and reliable scale for Female Infertility Stigma Questionnaire (F-ISQ) would be helpful for future studies to assess the status of this situation. It also helps planning interventional studies for improvement of the reproductive health of infertile women.
Comparison of Advanced Platelet Rich Fibrin (A-PRF) and Culture Media Conditioned Warton's Jelly (CMCWJ) on Fibroblast Cells Proliferation

Objective: To compare the potency of fibroblast cells proliferation in 12.5% and 25% Culture Media Conditioned Warton's Jelly (CMCWJ) and Advanced Platelet Rich Fibrin (A-PRF) cultured medium. Material and Methods: Fibroblast cells were divided into five groups: Group I (Control Group): serum-starved fibroblast without any treatment as a negative control; Group II: fibrolast that supplemented in 12.5% CMCWJ medium; Group III: fibrolast that supplemented 12.5% A-PRF medium; Group IV: fibrolast that supplemented 25% CMCWJ medium, and Group V: fibrolast that supplemented 25% A-PRF medium. The fibroblasts proliferation was counted by an automated cell counter. Statistical analysis was performed using One-way ANOVA and Post hoc Tamhane test was conducted to analyze the potential fibroblast proliferation differences in different concentration of CMCWJ and A-PRF group. Results: There were no significant differences in the fibroblast cell proliferation between GI and GIV, GII and GIV, GII and GIII, GII and GV, also GIV and GV. There were significant differences between GI and GII, GI and GIII, GI and GV, also GIII and GIV. Conclusion: The 12.5% CMCWJ group, 12.5% A-PRF group and 25% A-PRF group has excellent potential ability of fibroblast cells proliferation, meanwhile 25% CMCWJ group has the lowest mean potency of fibroblast cells proliferation compared to other groups. The 12.5% A-PRF Group has the highest mean of fibroblast cell proliferation amongst other groups.
Genotypic characterization of Escherichia coli strains isolated from dairy cattle environment

The aim of this study was to characterize the diversity of Escherichia coli strains involved in the dispersion of virulence genes. 152 E. coli strains originated from dairy cattle environment were evaluated through phenotypic and proteomic assays. These samples were investigated for the presence of virulence genes (eaeA, stxI, stxII, ST, LT, eagg, ial) and biofilm related genes (fimH, csgA, flu). Eighteen profiles were obtained and 30 isolates were selected for macrorestriction assay by Pulsed-Field Gel Electrophoresis (PFGE) technique. PFGE patterns of XbaI-digested performed to determine the clonal relatedness of E coli isolates. A total of 27 pulsotypes of E. coli were identified with a low percentage of genetic similarity (≤68%) demonstrating a high genetic diversity in the isolates tested. Furthermore, the presence of biofilm-associated related gene (fimH) can contribute to the dispersion and persistence of this pathogen into the milk environment. Also, all of the pulsotypes (n = 8) with genetic similarity from 95% were present in milk samples, feces and liner were found in different seasons of the year, sharing at least one gene associated with biofilm formation. So the characterization of the genetic diversity of E. coli is important for understanding its dispersion in order to assist in the implementation of measures to prevent the spread of these agents in milk production environment. Key words: circulating clones, diversity, Escherichia coli, persistence, Pulsed-Field Gel Electrophoresis (PFGE), virulence gene.
Vimy, Gallipoli, trauma, and the poetics of grief : re-reading the myths of the First World War in Jane Urquhart's The Stone Carvers and Brenda Walker's The Wing of Night

The article is a comparative analysis of The Stone Carvers (2001) by Canadian author Jane Urquhart and The Wing of Night (2005) by Australian writer Brenda Walker, which explore the First World War and its aftermath. My purpose is to demonstrate how the two novels engage with the foundational myths of Vimy and Gallipoli by representing the two battles from unusual perspectives. Instead of celebrating the violent crisis seen as the birthplace of their respective nations, Urquhart and Walker foreground violence as the foundation of the nation-state. Using trauma theories, I explore Urquhart’s and Walker’s representation of war injuries, as well as the traumatic impact of national ideologies on personal and collective identities. While both texts offer an insightful re-reading of the myths of the Great War, Urquhart creates a vision of harmony resulting from the tragedy of the past, whereas Walker’s gesture of revision is more radical, as she insists on the impossibility of post-war reconstruction.
Plug-in Electric Vehicle Charging With Multiple Charging Options: A Systematic Analysis of Service Providers’ Pricing Strategies

In this article, we present the optimal strategy for public plug-in electric vehicle (PEV) charging services with multiple charging options: fast charging service and slow charging service. The PEV user make decisions by firstly considering the remaining energy, travel distance to charging station, then about the charging prices, charging rates and estimated charging time. To obtain insights of such a highly coupled system, we consider both monopoly and duopoly markets, where the two services are operated by a single service provider (SP) and two different SPs, respectively. For the monopoly market, we propose a three-stage Stackelberg game model. For the duopoly market, we propose a two-stage Bertrand competition and Cournot competition. We provided the SP’s optimal pricing strategies and decisions in the monopoly market, and the optimal pricing contract and quantity contract for SPs in the duopoly market with Bertrand competition and Cournot competition. Both the analytical and simulation results show that, in the monopoly market, offering two charging options can potentially improve the SP’s profit compared with offering one option only in the monopoly market; while in the duopoly market, it is optimal for SPs to offer the quantity contract rather than the price contract to maximize profits.
Unfolding to the Past: Temporal and Dimensional Perception Enrichment for Image Impression Improvement

An image is in essence a record of visible objects at a particular point in time. This paper proposes a method based on adaptively integrating depth cues with relative motion for enriching temporal and dimensional perception of images. The key idea of our method is to construct a natural-looking animated sequence of images from the original one by introducing differing depth cues and varying time frames to individual generated images. The differing depth cues are created by utilizing variations of visual details and color saturation, whereas the presentation time duration of each image is determined based on structural similarity of consecutive images. The resulting animated image can give a sense of increasing depth as well as a temporal dynamics from past to present. The proposed method can be applied to image impression improvement, especially in the exhibitions or presentations of historical places and artifacts.
Hepatic Encephalopathy after Transjugular Intrahepatic Portosystemic Shunt Creation

Abstract Transjugular intrahepatic portosystemic shunt (TIPS) creation is effective in treating the sequelae of decompensated liver cirrhosis—including medically refractory ascites and variceal bleeding—by decompressing the portal venous system through a manmade portosystemic conduit within the liver. However, the altered physiology in which splenomesenteric blood bypasses intrahepatic portal venous perfusion can precipitate varying degrees of hepatic encephalopathy (HE). While the majority of post-TIPS HE cases can be treated medically, some require escalated management strategies, including endovascular interventions to modify the indwelling TIPS and/or occlude competitive physiologic spontaneous portosystemic shunts. This review article details the epidemiology, risk factors, diagnosis, classification, and treatment of post-TIPS HE.
The Role of Micronutrients in the Treatment of Idiopathic Abnormal Sperm Parameters

In spite of the presence of large number of male infertility pharmaceuticals agents and strategies, there is a renewed interest in remedies from micronutrient sources because of their lesser side effects and low cost. In this clinical trial that included male subjects aged from 20 to 60 years with at least 1 year of infertility and abnormal semen analysis who received 3 -6 months’ treatment with a Cyclofert men that contains (l-carnitine l-tartarate 1g, N – Asetyl cysteine 600 mg, 40 mg zinc, Lycopene 20 mg, 60 mg vitamin E, 200 mg vitamin C, 80 mg glutathione, 200 μg selenium, 100 mg coenzyme Q10 and 400 μg folic acid. Theses micronutrients were given in a form of two tablets/ twice a day for 6 months). Sperm parameters (count, motility, and morphology) and pregnancy incidence were monitored before and after treatment. The collected data showed that there was an overall progressive motility after 3 and 6 months of treatment. Moreover, the sperm count increased by 64% (3 months), (6 months) 88% (α = 0.00, 1, at P<0.05) compared to the untreated group. Furthermore, treatment for three and six months significantly improved the sperm morphology (p<0.05). These positive changes ameliorated the women’s ability to get pregnant in which 30 % of women got pregnant after 6 months of the treatment. However, all of these improvements are proportional with the duration of treatment. Research Article Citation: Elmahaishi LM, Abbas AA, Elmahaishi MS. The Role of Micronutrients in the Treatment of Idiopathic Abnormal Sperm Parameters. Gynecol Reprod Health. 2017; 1(2): 1-8.
Information Extraction from Polish Radiology Reports Using Language Models

Radiology reports are vital elements of directing patient care. They are usually delivered in free text form, which makes them prone to errors, such as omission in reporting radiological findings and using difficult-to-comprehend mental shortcuts. Although structured reporting is the recommended method, its adoption continues to be limited. Radiologists find structured reports too limiting and burdensome. In this paper, we propose the model, which is meant to preserve the benefits of free text, while moving towards a structured report. The model automatically parametrizes Polish radiology reports based on language models. The models were trained on a large dataset of 1200 chest computed tomography (CT) reports annotated by multiple medical experts reports with 44 observation tags. Experimental analysis shows that models based on language models are able to achieve satisfactory results despite being pre-trained on general domain corpora. Overall, the model achieves an F1 score of 81{% and is able to successfully parametrize the most common radiological observations, allowing for potential adaptation in clinical practice. Our model is publically available.
Effects of Different Seed Coating Ratios of an Organic Acid Mixture on Yield and Quality of Bread Wheat

This research was conducted during 2016-2017 awheat growing season to investigate the effects of different rates of seed coating of an organic acid mixture (citric acid, glutamate, and proline) on yield and quality of wheat. The field experiments were established in Dogankent and Haciali locations of Eastern Mediterranean Agricultural Research Institute in Turkey. Study was carried out with randomised complete block design with 4 replications and Ceyhan-99 bread wheat variety was used as seed material. Before seeding, wheat seeds were coated with organic acid mixture product (0.75% citric acid, 0.25% glutamate, 0.25% proline, 2% Zn and 96.75 water), in three different doses (500 ml ton-1, 1 l ton-1, 1.5 l ton-1) to compare with control (uncoated). There were statistically significant differences at 5% level in 1000 grain weight and grain yield values in Dogankent location and 1000 grain weight, grain yield and number of spikes in Hacialilocation. Highest yield values were obtained from 500 ml t-1 application dose for both locations. With 500 ml t-1 application dose at Dogankent location, grain yield was 11.9 t ha-1 which was 8.97% higher over control. In Hacali location, 500 ml t-1 application dose was increased yield by 15.96% compared to control which resulted with 10.5 t ha-1 grain yield. No statistically significant difference was observed in quality characteristics (protein, gluten, hardiness and sedimentation) in trials.
GREEN FERTILIZATION WITH RESIDUES OF LEGUMINOUS TREES FOR CULTIVATING MAIZE IN DEGRADED SOIL

ABSTRACT The objective of this study was to evaluate the effects of the addition of parts of leguminous trees on the growth and nutrition of maize (Zea mays L.), as well as on the chemical attributes of a degraded soil, 65 days after applying the residues. The experiment was conducted in pots, in a randomized block design with ten treatments and four replicates. The evaluated treatments were: T1 - No residues of leguminous trees, T2 - Leaves of Mimosa caesalpiniifolia, T3 - Branches of Mimosa caesalpiniifolia, T4 - Leaves + branches of Mimosa caesalpiniifolia, T5 - Leaves of Mimosa hostilis, T6 - Branches of Mimosa hostilis, T7 - Leaves + branches of Mimosa hostilis, T8 - Leaves of Gliricidia sepium, T9 - Branches of Gliricidia sepium and T10 - Leaves + branches of Gliricidia sepium. Pots were filled with soil from a degraded area and residues were added in the form of green mass after sowing the maize. Residues of leguminous trees positively influenced maize growth at 65 days after application and favored the accumulation of nitrogen, phosphorus and potassium in the shoots. Green fertilizers improved soil chemical attributes at 65 days after application, especially nitrate-N (NO3 --N), ammonium-N (NH4 +-N), total inorganic N (NO3 --N + NH4 +-N) and K, demonstrating that these species are good options for recovering degraded areas in the semi-arid region of Ceará.
Involucrin, cytokeratin 10 and Ki67 expression in a threedimensional cultured canine keratinocyte cell line in comparison to canine skin and cutaneous squamous cell carcinoma and a pilot study on custom-designed siRNA-INV transfection

Involucrin (INV) is a well-known early stage marker of terminal keratinocyte differentiation in humans. Besides its importance in human cancer, it has been predicted to be a prognostic marker in canine skin cancer. However, there is very little information available on canine INV. Therefore, for the first time, a three-dimensional (3D) cultured canine keratinocyte cell line was evaluated for the expression level of INV and two other cancer prognostic parameters, cytokeratin 10 (CK10) and Ki67, compared to that in canine normal skin (CN) and cutaneous squamous cell carcinoma (CSCC) cells. The INV protein and transcript expression levels were significantly ( p < 0.005) higher in canine CN compared to in CSCC, whereas Ki67 expression levels were significantly ( p < 0.05) lower in CN than in CSCC. The culture of a commercial canine keratinocyte cell line (CPEK; CELLnTEC Advanced Cell Systems, Switzerland) to produce the 3D epidermal skin was successfully achieved under an air-liquid interface for 14 d of culture. There was no statistical difference in the INV and CK10 expression levels between the 3D-cultured CPEK cells and CN. A custom designed INV siRNA transfected at 300 pmol showed the high efficacy of INV knockdown with minimum cytotoxicity to cultured CPEK cells, significantly reducing the INV mRNA expression level after 5 h transfection for up to 48 h. This is the first report on the custom design of siRNA transfection in monolayer cultured CPEK cells for INV gene knockdown in dogs and it could be useful for future studies on the carcinogenesis of CSCC.
Sex-dependent differences in pain and sleep in a porcine model of Neurofibromatosis type 1

Neurofibromatosis Type 1 (NF1) is an autosomal dominant genetic disorder resulting from germline mutations in the NF1 gene, which encodes neurofibromin. Patients experience a variety of symptoms, but pain in the context of NF1 remains largely underrecognized. Here, we characterize nociceptive signaling and pain behaviors in a miniswine harboring a disruptive NF1 mutation (exon 42 deletion). We explore these phenotypes in relationship to collapsin response mediator protein 2 (CRMP2), a known interactor of neurofibromin. Mechanistically, we found two previously unknown phosphorylated residues of CRMP2 in NF1+/ex42del pig dorsal root ganglia (DRGs) and replicated increased voltage-gated calcium channel currents in NF1+/ex42del pig DRGs previously described in rodent models of NF1. We present the first characterization of pain-related behaviors in a pig model of NF1, identifying unchanged agitation scores, lower tactile thresholds (allodynia), and decreased response latencies to thermal laser stimulation (hyperalgesia) in the NF1 mutant animals; NF1+/ex42del pigs demonstrated sexually dimorphic behaviors. NF1+/ex42del pigs showed reduced sleep quality and increased resting, two health-related quality of life symptoms found to be comorbid in people with NF1 pain. Finally, we show decreased depolarization-evoked calcium influx in both wildtype and NF1+/ex42del pig DRGs treated with CRMP2 phosphorylation inhibitor (5)-lacosamide. Our data supports use of NF1+/ex42del pigs as an ideal model for studying NF1-associated pain and are a better model for understanding the pathophysiology of NF1 compared to rodents. Moreover, our findings demonstrate that interfering with CRMP2 phosphorylation might be a promising therapeutic strategy for NF1-related pain management.
Single-Pixel Imaging Using Multimode Fiber and Silicon Photonic Phased Array

Due to the unique nature of offering minimal invasiveness and high spatial resolution simultaneously, multimode fibers (MMFs) are receiving significant attention in bio-imaging applications. While a spatial light modulator is typically used for controlling the wavefront of the light emitted from the MMF, it makes the system slow, bulky, and expensive. To solve this problem, in this work, we demonstrate the use of a chip-scale integrated optical phased array (OPA) for imaging through an MMF. A silicon OPA with 128 independent phase shifters is fabricated and combined with a 3D waveguide interface to generate speckle patterns at the MMF output. Using the generated speckles and the optical power detected by a bucket detector, we experimentally obtain fine 2D images of the target. From the point spread function analysis of the system, the number of resolvable points is derived to be 1007 points, which is much larger than the number of phase shifters.
Hatch date influences pre-fledging survival of temperate-nesting Canada geese

Among the numerous demographic parameters that influence population size, unbiased estimates of pre-fledging survival remain difficult to obtain for precocial birds. In this study, we used capture–mark–recapture modeling to estimate pre-fledging survival in a population of temperate-nesting Canada geese Branta canadensis maxima that has undergone an exponential increase over the last two decades. We examined whether pre-fledging survival was affected by relative hatch date, initial brood size, mother age, and weather conditions at hatching. Between 2005 and 2014, 8679 goslings were marked with web-tags at hatching at two adjacent sites. A total of 3922 of these birds were initially recaptured and banded before fledging while 338 were recaptured and banded in subsequent years as after-hatching year birds. Multistate models with joint live and dead encounters were used to estimate pre-fledging survival and evaluate the effects of rearing sites, gosling characteristics, and weather conditions at hatching. Pre-fledging survival of Canada geese varied between 0.45 (95% CI: 0.41–0.50) and 0.75 (0.62–0.84) among years and sites with an overall mean of 0.62 (0.54–0.68). Survival rates were lower for late hatched birds and tended to increase with initial brood size and mother age. Weather conditions at hatching did not affect pre-fledging survival. Significant effect of hatch date on pre-fledging survival has often been described in geese nesting in highly seasonal environments (e.g. the arctic) but our findings of such a relationship in temperate-nesting Canada geese indicate that a selection pressure on the timing of breeding can also occur at more stable temperate latitudes.