Miracle-dz/UniFAR-FTUs huggingface dataset:
Outcomes and Return to Sport After Pectoralis Major Tendon Repair: A Systematic Review

Context: Pectoralis major tendon ruptures are becoming increasingly common due to the growing prevalence of active lifestyles. Studies investigating the efficacy of pectoralis major tendon repair have limited sample sizes and offer mixed results, while existing reviews do not explore postoperative activity outcomes for patients. Objective: To summarize and synthesize the clinical outcomes and rate of return to activity after isolated pectoralis major tendon repair. Data Sources: Four databases (MEDLINE, EMBASE, PubMed, and CINAHL) were searched from database inception through March 7, 2018. Study Selection: Studies reporting outcomes of isolated pectoralis major tendon repair for pectoralis major tendon rupture were included. Study Design: Systematic review. Level of Evidence: Level 4. Data Extraction: Data including patient demographics, intervention details, and clinical outcomes were extracted. The methodological quality of included studies was evaluated. Results: Of 2332 retrieved articles, 18 studies were included, with a total of 536 patients. A majority (90%; 134/149) of patients undergoing pectoralis major tendon repair successfully returned to sport at a mean 6.1 ± 1.7 months postsurgery, of which 74% (95/128) successfully returned to their preinjury level of sport. The majority (95%; 269/284) of patients returned to work at a mean 6.9 ± 1 months. Postsurgically, 81% (83/102) of patients experienced complete pain relief after the surgery, and 19% (21/109) had cosmetic complaints after pectoralis major repair. Of the 10 studies that reported complications, 18% (75/423) of patients had postoperative complications, including reruptures and wound infections; 7% (30/423) of patients required reoperation for their complications. Conclusion: Pectoralis major tendon repair is an effective treatment that results in a high rate of return to sport and work, pain relief, and improved cosmetic appearance, albeit with a significant rate of complication. The evidence supporting all outcomes was limited by the rarity of the injury, the variable surgical techniques, and outcome assessment criteria.
The Efficacy of Near-Infrared Spectroscopy Monitoring in Carotid Endarterectomy: A Prospective, Single-Center, Observational Study

There has been no gold standard for intraoperative monitoring in carotid endarterectomy (CEA) till now. The purpose of the current study was to investigate the value of near-infrared spectroscopy (NIRS) monitoring in CEA and explore the thresholds for intraoperative cerebral hypoperfusion. Eighty-four consecutive patients who underwent CEA surgery in Xuan Wu Hospital of Capital Medical University from August 2015 to June 2016 were enrolled in this study. All patients were intraoperatively monitored by transcranial Doppler ultrasonography (TCD) and NIRS. Regional oxygen saturation (rSO2) monitored by NIRS and blood flow velocity of the middle cerebral artery (V-MCA) monitored by TCD were continuously recorded. Correlation analysis was conducted for NIRS and TCD monitoring values. Intraoperative shunting was performed in five patients according to the TCD monitoring results and surgeon preference. During clamping of the carotid artery, the Pearson correlation index between rSO2 and V-MCA was 0.581 (P<0.001). A cut-off of 12.3% decrease of rSO2 was identified as the optimal threshold for intraoperative hypoperfusion indicated by TCD monitoring, when the sensitivity and specificity were 64.3% and 90.0%, respectively, with a 0.570 Kappa value. Physical examination immediately after operation showed no ischemic injury occurred, and no death and stroke occurred during the postoperative hospitalization. Our study demonstrated that NIRS could serve as a favorable monitoring tool during CEA. A 12.3% decrease of rSO2 could be adopted as a reliable threshold for intraoperative cerebral hypoperfusion.
A New Era of Cardiac Cell Therapy: Opportunities and Challenges

Myocardial infarction (MI), caused by coronary heart disease (CHD), remains one of the most common causes of death in the United States. Over the last few decades, scientists have invested considerable resources on the study and development of cell therapies for myocardial regeneration after MI. However, due to a number of limitations, they are not yet readily available for clinical applications. Mounting evidence supports the theory that paracrine products are the main contributors to the regenerative effects attributed to these cell therapies. The next generation of cell‐based MI therapies will identify and isolate cell products and derivatives, integrate them with biocompatible materials and technologies, and use them for the regeneration of damaged myocardial tissue. This review discusses the progress made thus far in pursuit of this new generation of cell therapies. Their fundamental regenerative mechanisms, their potential to combine with other therapeutic products, and their role in shaping new clinical approaches for heart tissue engineering, are addressed.
Root dentinal microcracks: a post-extraction experimental phenomenon?

Ple a s e no t e: Ch a n g e s m a d e a s a r e s ul t of p u blishing p roc e s s e s s uc h a s copy-e di ting, for m a t ting a n d p a g e n u m b e r s m ay no t b e r eflec t e d in t his ve r sion. For t h e d efini tive ve r sion of t his p u blica tion, ple a s e r efe r to t h e p u blish e d sou rc e . You a r e a dvis e d to cons ul t t h e p u blish e r’s ve r sion if you wis h to ci t e t his p a p er.
Automatic multi-label segmentation of the preterm brain with the use of adaptive atlases

Antonios Makropoulos, Ioannis S. Gousias, Christian Ledig, Paul Aljabar, Ahmed Serag, Joseph V. Hajnal, A. David Edwards, Serena J. Counsell, and Daniel Rueckert Centre for the Developing Brain, Imperial College London, London, United Kingdom, Biomedical Image Analysis Group, Department of Computing, Imperial College London, London, United Kingdom, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom
Molecular cloning and comparative analysis of transcripts encoding chemosensory proteins from two plant bugs, Lygus lineolaris and Lygus hesperus

Chemosensory proteins (CSPs) are soluble carrier proteins typically characterized by a six‐helix bundle structure joined by two disulfide bridges and a conserved Cys spacing pattern (C1‐X6‐8‐C2‐X16‐21‐C3‐X2‐C4). CSPs are functionally diverse with reported roles in chemosensation, immunity, development, and resistance. To expand our molecular understanding of CSP function in plant bugs, we used recently developed transcriptomic resources for Lygus lineolaris and Lygus hesperus to identify 17 and 14 CSP‐like sequences, respectively. The Lygus CSPs are orthologous and share significant sequence identity with previously annotated CSPs. Three of the CSPs are predicted to deviate from the typical CSP structure with either five or seven helical segments rather than six. The seven helix CSP is further differentiated by an atypical C3‐X3‐C4 Cys spacing motif. Reverse transcriptase PCR‐based profiling of CSP transcript abundance in adult L. lineolaris tissues revealed broad expression for most of the CSPs with antenna specific expression limited to a subset of the CSPs. Comparative sequence analyses and homology modeling suggest that variations in the amino acids that comprise the Lygus CSP binding pockets affect the size and nature of the ligands accommodated.
Comparison of Health-Related Quality of Life Between Adjuvant Breast Cancer Treatment Groups.

OBJECTIVES To compare the health-related quality of life (HRQOL) of women who did (receivers, n = 372) and did not (intentional nonreceivers, n = 46) receive all recommended adjuvant treatments for breast cancer. SAMPLE & SETTING Women were recruited through integrative oncology clinics and the Cancer Surveillance System registry in western Washington. METHODS & VARIABLES A cross-sectional and correlational study using secondary data was conducted. Self-reported data included involvement in treatment decision making (TDM) and HRQOL. Registry data included demographics, disease characteristics, and records on recommended treatments as well as receiving/not receiving them. Descriptive statistics, t tests, chi-square tests, correlations, and analysis of variance were used to compare receivers and intentional nonreceivers. RESULTS Among women who were "very involved" in TDM and those who reported their involvement as "just right," intentional nonreceivers scored higher in role-physical, general health, and vitality than receivers after controlling for demographic and disease characteristics. IMPLICATIONS FOR NURSING Nurses need to be aware that intentional nonreceivers of adjuvant therapy, particularly if assessed as "very involved" and "just right" involvement in deciding to refuse treatment, may report better HRQOL than receivers, which could be attributed to lack of common side effects from adjuvant treatment.
Combined Cytotoxicity of the Phycotoxin Okadaic Acid and Mycotoxins on Intestinal and Neuroblastoma Human Cell Models

Mycotoxins are emerging toxins in the marine environment, which can co-occur with algal toxins to exert synergistic or antagonistic effects for human seafood consumption. The current study assesses the cytotoxicity of the algal toxin okadaic acid, shellfish, and dust storm-associated mycotoxins alone or in combination on human intestinal (HT-29) and neuroblastoma (SH-SY5Y) cell lines. Based on calculated IC50 (inhibitory concentration 50%) values, mycotoxins and the algal toxin on their own exhibited increased cytotoxicity in the order of sydowinin A < sydowinin B << patulin < alamethicin < sydowinol << gliotoxin ≈ okadaic acid against the HT-29 cell line, and sydowinin B < sydowinin A << alamethicin ≈ sydowinol < patulin, << gliotoxin < okadaic acid against the SH-SY5Y cell line. Combinations of okadaic acid–sydowinin A, –alamethicin, –patulin, and –gliotoxin exhibited antagonistic effects at low-moderate cytotoxicity, but became synergistic at high cytotoxicity, while okadaic acid–sydowinol displayed an antagonistic relationship against HT-29 cells. Furthermore, only okadaic acid–sydowinin A showed synergism, while okadaic acid–sydowinol, –alamethicin, –patulin, and –gliotoxin combinations demonstrated antagonism against SH-SY5Y. While diarrhetic shellfish poisoning (DSP) from okadaic acid and analogues in many parts of the world is considered to be a comparatively minor seafood toxin syndrome, our human cell model studies suggest that synergisms with certain mycotoxins may aggravate human health impacts, depending on the concentrations. These findings highlight the issues of the shortcomings of current regulatory approaches, which do not regulate for mycotoxins in shellfish and treat seafood toxins as if they occur as single toxins.
The use of ETView endotracheal tube for surveillance after tube positioning in patients undergoing lobectomy, randomized trial

Abstract The ETView tracheoscopic ventilation tube (TVT) is a tracheal tube (TT) incorporating a video camera and a light source in its tip. The view from the tip appears continuously on a portable monitor in the anesthesia area. We evaluated the effectiveness and usefulness of the single/double ETView TVT in monitoring the tracheal tube position during general anesthesia undergoing video-assisted thoracoscopic lobectomy. Eighty-three patients with pulmonary bullae (American Society of Anesthesiologists (ASA) I-III) undergoing lobectomy, with general anaesthesia, were included. Patients were randomly assigned to 3 groups, based on the tube ETView double-lumen tube (VDT), ETView single-lumen tube (VST), or traditional double lumen tube (DT). All 83 patients’ intubations were successful to achieve 1-lung ventilation: 74 patients at the first attempt (22/26 in VDT, 26/28 in VST, 26/29 in DT group) and 9 patients at the second attempt. The time to achieve 1-lung ventilation with the VDT was 58.5 ± 21.5 (mean ± SD) seconds, the VST was 38.2 ± 10.1 (mean ± SD) seconds, and the DT group was 195.5 ± 40.3 (mean ± SD) seconds. During operations, the ETView tubes provided continuous airway visualization in all patients; a good view was obtained in 24/25 patients in VDT/VST, moderate in 4/12 patients in VDT/VST, and poor in 1/1 patients in VDT/VST. When the patient left the postanesthesia care unit, all had sore throat and 26/15/25 patients in VDT/VST/DT group had hoarseness. All had good outcomes of the surgical operations. We found the ETView tube to be helpful in the endotracheal intubation and continuous surveillance of tube position in patients with video-assisted thoracoscopic lobectomy. The ETView single lumen endotracheal tube had fewer associated complications and is superior to the 2 double-lumen tubes.
Cellular transplant: functional, immunocytochemical and histopathologic analysis in an experimental model of ischemic heat disease using different cells

OBJECTIVE: To present the functional, immunocytochemical and histopathologic results (in vitro or in heart specimens) after isolation, culture and co-culture of mesenchymal stem cells and skeletal myoblast cells transplanted and co-transplanted in experimental animals with ischemic heart disease and left ventricular ejection fractions lower than 40%. METHOD: We utilized 72 Wistar rats, divided into four groups according to the culture media or injected cells: control group into which only culture media was injected (22 rats); mesenchymal stem cell group (17 rats); myoblast skeletal cell group (16 rats) and co-culture group (17 rats). In the immunohistochemical studies, the cells were stained with anti-vimentin, anti-desmin and anti-myosin. In the histopathologic analysis, slides were stained with Gomori Trichrome, and neo-vessels and muscle tissues were identified. In the functional analysis the left ventricle ejection fraction was analyzed one week after myocardial infarction and one month after the injection. RESULTS: The initial left ventricle ejection fraction (control echo) was not statistically significant between the four groups (P=0.276), but was significantly different in the follow-up examination (P=0.001). This difference was seen between the control and the myoblast skeletal cells groups (P=0.037), between the control and the co-culture groups (P<0.001), and between the mesenchymal stem cell and co-culture groups (P=0.025). When the initial and final echocardiograms in each group were compared, the control group deteriorated (P=0.005) and the co-culture group improved (P=0.006). With the immunocytochemical in vitro analysis, mesenchymal stem cells were identified when stained with anti-vimentin and muscle cells when stained with anti-desmin. In the heart specimens, muscle tissue, stained with anti-desmin and skeletal myoblasts cells, stained with fast anti-miosin were identified. In the histopathologic analysis, new vessels were observed in the mesenchymal stem cell and skeletal myoblast groups, and muscular tissue, angiogenesis and myogenesis in the co-culture group. CONCLUSION: The left ventricle ejection fraction improved in the group in which muscle cells were injected and more strikingly in the co-culture group. The immunohistochemical findings in the culture and co-culture groups evidenced the corresponding cells. In the heart specimens, muscle and skeletal myoblast cells were found. In the histopathologic examination, new vessels and muscle tissue were found in the mesenchymal stem cell, skeletal myoblast cell and co-culture groups.
3T chemical shift‐encoded MRI: Detection of altered proximal femur marrow adipose tissue composition in glucocorticoid users and validation with magnetic resonance spectroscopy

Osteoporosis (OP) results in weak bone and can ultimately lead to fracture. Drugs such as glucocorticoids can also induce OP (glucocorticoid‐induced osteoporosis [GIO]). Bone marrow adipose tissue composition and quantity may play a role in OP pathophysiology, but has not been thoroughly studied in GIO compared to primary OP.
Re-evaluating MPEG motion compensation search criteria

As general-purpose processors evolve from single-issue machines to more advanced multiple-issue designs using dynamic instruction scheduling, speed-critical algorithms should be re-examined to ensure that the optimal strategy is being used. One important example of this class of algorithms is MPEG encoding. In MPEG encoding, the mean square error search criterion achieves better compression quality than the mean absolute distance criterion. However, the mean absolute distance approach is recognized in the literature as more efficient in terms of speed. Our research indicates that the mean square error approach becomes much more attractive as instruction-level parallelism (ILP) increases. In a general-purpose processor that can exploit a high degree of instruction-level parallelism, the mean square error approach yields both better performance and better compression quality. Additional algorithms should likewise be re-evaluated to ensure efficient execution on high-ILP machines.
Interatrial septal fat thickness and left atrial stiffness are mechanistic links between nonalcoholic fatty liver disease and incident atrial fibrillation

Recently, a clear evidence suggests that nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of incident atrial fibrillation (AF). Yet, the underlying pathogenesis is speculative. Thereby, we aimed to investigate the hypothesis that, interatrial thickness (IAST) and left atrial stiffness (LASt) might have mechanistic links between NAFLD and AF.
ROI and phobias: The effect of ROI approach on an ALE meta‐analysis of specific phobias

About 90% of fMRI findings on specific phobias (SP) include analysis of region of interest (ROI). This approach characterized by higher sensitivity may produce inflated results, particularly when findings are aggregated in meta‐analytic maps. Here, we conducted a systematic review and activation likelihood estimation (ALE) meta‐analysis on SP, testing the impact of the inclusion of ROI‐based studies. ALE meta‐analyses were carried out either including ROI‐based results or focusing on whole‐brain voxelwise studies exclusively. To assess the risk of bias in the neuroimaging field, we modified the Newcastle–Ottawa Scale (NOS) and measured the reliability of fMRI findings. Of the 31 selected investigations (564 patients and 485 controls) one‐third did not motivate ROI selection: five studies did not report an explicit rationale, whereas four did not cite any specific reference in this regard. Analyses including ROI‐based studies revealed differences between phobics and healthy subjects in several regions of the limbic circuit. However, when focusing on whole‐brain analysis, only the anterior midcingulate cortex differentiated SP from controls. Notably, 13 studies were labeled with low risk of bias according to the adapted NOS. The inclusion of ROI‐based results artificially inflates group differences in fMRI meta‐analyses. Moreover, a priori, well‐motivated selection of ROIs is desirable to improve quality and reproducibility in SP neuroimaging studies. Lastly, the use of modified NOS may represent a valuable way to assess and evaluate biases in fMRI studies: “low risk” of bias was reported for less than half of the included studies, indicating the need for better practices in fMRI.
Texture in Penderecki’s Sonoristic Style

In his so-called "sonoristic" period of the early 1960s--represented by pieces such as Threnody, Fluorescences, Polymorphia, and others--Penderecki employed a compositional system whose axiomatic concept was not a single sound, but the sound matter in its totality. Distinct states of this sound matter were governed by two relatively independent systems: (1) a basic system which ruled the texture of sound masses and (2) a timbre system governing their sound color. Categories of the basic system are a few binary oppositions concerning pitch, time, and loudness: spatial mobility vs. immobility, temporal mobility vs. immobility, spatial continuity vs. discontinuity, temporal continuity vs. discontinuity, high vs. low register, loud vs. soft dynamics. These categories account for the morphology of the basic system because a combination of terms chosen from individual categories generates an inventory of units in Penderecki's sonoristic style. The same set of categories also determines syntax, as the temporal order of units in the course of musical narration is ruled by the internal logic of individual binary oppositions. Categories of the timbre system are in turn metal, wood, and leather--materials of which the sound sources of traditional musical instruments are most often made--forming a ternary opposition. The timbre system underlies the wealth of new musical tools as well as eccentric playing techniques on traditional instruments called for by the composer.
College Students and Alcohol Abuse: A Test of Social Learning, Strain, and Acculturation Theories

This article uses an original data set to explore the utility of three classic sociological theories to test patterns of college student alcohol consumption: social learning, strain, and acculturation. The survey data indicate that the first two theories are supported. Acculturation, however, does not appear to explain variations in drinking habits of Latino students in our sample.
Structural Moieties Required for Cinnamaldehyde-Related Compounds to Inhibit Canonical IL-1β Secretion

Suppressing canonical NOD-like receptor protein 3 (NLRP3) inflammasome-mediated interleukin (IL)-1β secretion is a reliable strategy for the development of nutraceutical to prevent chronic inflammatory diseases. This study aimed to find out the functional group responsible for the inhibitory effects of cinnamaldehyde-related compounds on the canonical IL-1β secretion. To address this, the suppressing capacities of six cinnamaldehyde-related compounds were evaluated and compared by using the lipopolysaccharide (LPS)-primed and adenosine 5′-triphosphate (ATP)-activated macrophages. At concentrations of 25~100 μM, cinnamaldehyde and 2-methoxy cinnamaldehyde dose-dependently inhibited IL-1β secretion. In contrast, cinnamic acid, cinnamyl acetate, cinnamyl alcohol and α-methyl cinnamaldehyde did not exert any inhibition. Furthermore, cinnamaldehyde and 2-methoxy cinnamaldehyde diminished expressions of NLRP3 and pro-IL-1β. Meanwhile, cinnamaldehyde and 2-methoxy cinnamaldehyde prevented the ATP-induced reduction of cytosolic pro-caspase-1 and increase of secreted caspase-1. In conclusion, for cinnamaldehyde-related compounds to suppress NLRP3 inflammasome-mediated IL-1β secretion, the propenal group of the side chain was essential, while the substituted group of the aromatic ring played a modifying role. Cinnamaldehyde and 2-methoxy cinnamaldehyde exerted dual abilities to inhibit canonical IL-1β secretion at both stages of priming and activation. Therefore, there might be potential to serve as complementary supplements for the prevention of chronic inflammatory diseases.