Miracle-dz/UniFAR-FTUs huggingface dataset:
A MAPP Network Case-Control Study of Urologic Chronic Pelvic Pain Compared with Non-Urologic Pain Conditions.

OBJECTIVES Limited research suggests commonalities between urologic chronic pelvic pain syndromes (UCPPS) and other non-urologic chronic overlapping pain conditions (COPCs) including fibromyalgia, chronic fatigue syndrome, and irritable bowel syndrome. The goal of this case-control study was to examine similarities and differences between UCPPS and these other COPCs. METHODS As part of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network, we examined 1,039 individuals with UCPPS (n=424), non-urologic COPCs (n=200), and healthy controls (n=415). Validated standardized measures were used to assess urological symptoms, non-urological pain symptoms, and psychosocial symptoms and traits. RESULTS Participants with UCPPS had more urologic symptoms than non-urologic COPCs or healthy controls (P<0.001); non-urological COPC group also had significantly worse urological symptoms than healthy controls (P<0.001). Participants with non-urological COPCs reported more widespread pain than those with UCPPS (P<0.001), yet both groups had similarly increased symptoms of anxiety, depression, negative affect, perceived stress, neuroticism, and lower levels of extraversion than healthy controls (P<0.001). Participants with UCPPS with and without COPCs reported more catastrophizing than those with non-urological COPCs (P<0.001). DISCUSSION Findings are consistent with the hypothesis of common underlying biopsychosocial mechanisms and can guide the comprehensive assessment and treatment of these conditions regardless of the primary site of pain or diagnosis. Heightened catastrophizing in UCPPS should be examined to inform psychosocial interventions and improve patient care.
Size-Dependent Properties of Magnetosensitive Polymersomes: Computer Modelling

Magnetosensitive polymersomes, which are amphiphilic polymer capsules whose membranes are filled with magnetic nanoparticles, are prospective objects for drug delivery and manipulations with single cells. A molecular dynamics simulation model that is able to render a detailed account on the structure and shape response of a polymersome to an external magnetic field is used to study a dimensional effect: the dependence of the field-induced deformation on the size of this nanoscale object. It is shown that in the material parameter range that resembles realistic conditions, the strain response of smaller polymersomes, against a priori expectations, exceeds that of larger ones. A qualitative explanation for this behavior is proposed.
Synergistic Effects of Two-Dimensional MXene and Ammonium Polyphosphate on Enhancing the Fire Safety of Polyvinyl Alcohol Composite Aerogels

Fire and smoke suppressions of polyvinyl alcohol (PVA) aerogels are urgently required due to the serious fire hazard they present. MXene, a 2D transition-metal carbide with many excellent properties, is considered a promising synergist for providing excellent flame retardant performance. PVA/ammonium polyphosphate (APP)/transition metal carbide (MXene) composite aerogels were prepared via the freeze-drying method to enhance the flame retardancy. Thermogravimetric analysis, limiting oxygen index, vertical burning, and cone calorimeter tests were executed to investigate the thermal stability and flame retardancy of PVA/APP/MXene (PAM) composite aerogels. The results demonstrated that MXene boosted the flame retardancy of PVA-APP, and that PAM-2 (with 2.0 wt% MXene loading) passed the V-0 rating, and reached a maximum LOI value of 42%; Moreover, MXene endowed the PVA-APP system with excellent fire and smoke suppression performance, as the the peak heat release rate and peak smoke production rate were significantly reduced by 55% and 74% at 1.0 wt% MXene loading. The flame retardant mechanism was systematically studied, MXene facilitated the generation of compact intumescent residues via ita catalyst effects, thus further restraining the release of heat and smoke. This work provides a simple route to improve the flame retardancy of PVA aerogels via the synergistic effect of MXene and APP.
Transcriptomic Profiles of Confirmed Pediatric Tuberculosis Patients and Household Contacts Identifies Active Tuberculosis, Infection, and Treatment Response among Indian Children.

BACKGROUND Gene expression profiling is emerging as a tool for tuberculosis diagnosis and treatment response monitoring, but limited data specific to Indian children and incident tuberculosis infection (TBI) exist. METHODS 16 pediatric Indian tuberculosis cases were age- and sex-matched to 32 tuberculosis-exposed controls (13 developed incident TBI without subsequent active tuberculosis). Longitudinal samples were collected for RNAseq. Differential expression analysis generated gene lists that identify tuberculosis diagnosis and tuberculosis treatment response. Data were compared with published gene lists. Population-specific risk score thresholds were calculated. RESULTS 71 genes identified tuberculosis diagnosis and 25 treatment response. Within-group expression was partially explained by age, sex, and incident TBI. Transient changes in gene expression were identified after both infection and treatment. Application of 27 published gene lists to our data found variable performance for tuberculosis diagnosis (sensitivity 0.38-1.00, specificity 0.48-0.93) and treatment response (sensitivity 0.70-0.80, specificity 0.40-0.80). Our gene lists found similarly variable performance when applied to published datasets for diagnosis (sensitivity 0.56-0.85, specificity 0.50-0.85) and treatment response (sensitivity 0.49- 0.86, specificity 0.50-0.84). CONCLUSIONS Gene expression profiles among Indian children with confirmed tuberculosis were distinct from adult-derived gene lists, highlighting the importance of including distinct populations in differential gene expression models.
The Logic of Conditional Party Government: Revisiting the Electoral Connection

One of the most influential and enduring books on Congress in the last three decades was David Mayhew's Congress: The Electoral Connection. Mayhew presented a purposive theory in which members were assumed to be motivated solely by a desire for reelection. Employing this assumption, he seemed able to account not only for most behavior by individual representatives, but also for much of the institutional structure of the House. The House, it was said, was organized to facilitate the reelection of the members. One pair of institutional features that were deemed by Mayhew to be of little import were the political parties. Their only purpose was to foster the electoral wellbeing of individual representatives, and otherwise leave them free to pursue their own interests. Yet in the years since The Electoral Connection was published, we have witnessed a resurgence of partisanship in Congress--in voting , in institutional processes, and in personal conflicts. Party leaders, especially on the majority side, have been granted powers that are greater than at any time since early in the century. How are we to understand these events in light of Mayhew’s analysis? Did he misunderstand the motives of members and their consequences, or are the changes over the last 30 years due to more complex processes that are still consistent with the theory of The Electoral Connection? In our previous work we have developed a theoretical argument—termed “Conditional Party Government” (or CPG for short)—that we believe accounts for the observed developments. In this chapter we will focus on the electoral connection from the point of view of CPG: how is it that, beginning with electorally independent members, we end up with high levels of party loyalty and party conflict,
Comparison of feature tracking, fast‐SENC, and myocardial tagging for global and segmental left ventricular strain

A multitude of cardiac magnetic resonance (CMR) techniques are used for myocardial strain assessment; however, studies comparing them are limited. We sought to compare global longitudinal (GLS), circumferential (GCS), segmental longitudinal (SLS), and segmental circumferential (SCS) strain values, as well as reproducibility between CMR feature tracking (FT), tagging (TAG), and fast‐strain‐encoded (fast‐SENC) CMR techniques.
High Hydration Factor in Older Hispanic-American Adults: Possible Implications for Accurate Body Composition Estimates

Age- and obesity-related body composition changes could influence the hydration factor (HF) and, as a result, body composition estimates derived from hydrometry. The aim of the present study was to compare the HF in older Hispanic-American adults to some published values. This cross-sectional study included a sample of 412 subjects, men and women, aged ≥60 years from northern Mexico. HF values were calculated based on the ratio of total body water-using the deuterium dilution technique-to fat-free mass, derived from the four-compartment model. The mean HF value for the total sample (0.748 ± 0.034) was statistically (p ≤ 0.01) higher than the traditionally assumed value of 0.732 derived from chemical analysis, the “grand mean’’ value of 0.725 derived from in vivo methods, and the 0.734 value calculated for older French adults via the three-compartment model. The HF of the older women did not differ across the fat mass index categories, but in men the obese group was lower than the normal and excess fat groups. The hydration factor calculated for the total sample of older Hispanic-American people is higher than the HF values reported in the literature. Therefore, the indiscriminate use of these assumed values could produce inaccurate body composition estimates in older Hispanic-American people.
Peak Detection with Online Electroencephalography (EEG) Artifact Removal for Brain–Computer Interface (BCI) Purposes

Brain–computer interfaces (BCIs) measure brain activity and translate it to control computer programs or external devices. However, the activity generated by the BCI makes measurements for objective fatigue evaluation very difficult, and the situation is further complicated due to different movement artefacts. The BCI performance could be increased if an online method existed to measure the fatigue objectively and accurately. While BCI-users are moving, a novel automatic online artefact removal technique is used to filter out these movement artefacts. The effects of this filter on BCI performance and mainly on peak frequency detection during BCI use were investigated in this paper. A successful peak alpha frequency measurement can lead to more accurately determining objective user fatigue. Fifteen subjects performed various imaginary and actual movements in separate tasks, while fourteen electroencephalography (EEG) electrodes were used. Afterwards, a steady-state visual evoked potential (SSVEP)-based BCI speller was used, and the users were instructed to perform various movements. An offline curve fitting method was used for alpha peak detection to assess the effect of the artefact filtering. Peak detection was improved by the filter, by finding 10.91% and 9.68% more alpha peaks during simple EEG recordings and BCI use, respectively. As expected, BCI performance deteriorated from movements, and also from artefact removal. Average information transfer rates (ITRs) were 20.27 bit/min, 16.96 bit/min, and 14.14 bit/min for the (1) movement-free, (2) the moving and unfiltered, and (3) the moving and filtered scenarios, respectively.
The challenge of medical waste management: a case study in northwest Iran-Tabriz

This article presents the results of a descriptive cross-sectional study on medical waste management in Tabriz (Iran's fourth largest city). The study was conducted in 10 of 25 active hospitals of the city in the summer of 2007. The methodology of the present study was based on data collected from hospitals through a checklist, site visits (observation), and quantity analysis by weight. The results indicated that more than 13.59 tonnes day—1 of total medical waste and 4.06 tonnes day—1 of hazardous-infectious medical waste are generated by the active hospitals of the city. Currently, there are no practical instructions, or suitable supervision on different levels of waste management. The health authorities and hospital managers do not accept sufficient responsibility for the medical waste due to financial problems and the lack of awareness regarding the hazards of medical waste. Segregation and minimization of waste are not carried out correctly in any of the hospitals. The use of protective measures by staff and temporary storage areas was not in agreement with standards in 70 and 60% of the hospitals in the present study, respectively. About 50% of the hospitals had been equipped with an incinerator, but all but one (10%) of them had been phased out due to operation and maintenance problems, air pollution, etc. Almost all of the hospitals have a waste management officer, but there is not an effective training programme for the staff. Infectious-hazardous medical waste is mixed with general waste, and it is disposed of in a municipal waste landfill, which is an unsanitary dumpsite. Illegal segregation and recycling of medical waste is carried out at the final disposal site; therefore, there are concerns about environmental pollution and the transmission of infectious diseases. It is proposed that, through the allocation of increased budgets, implementation of integrated segregation, minimization of waste, and creation of a training programme in the hospitals, the quantity of medical waste would be decreased (by about 70.11%). Considering the previous unsuccessful experience of on-site incineration in Tabriz (and in Iran's other large cites), an amendment should be made to Iran's current hazardous waste regulations to have infectious-hazardous waste sent to a central off-site autoclave or incinerator for treatment. The off-site autoclave would have some advantages, such as decreased air pollution. Of course, some health officials oppose this plan. To test this plan and receive the official's approval, a central off-site autoclave can be put into practice as a pilot.
Functional Metallic Microcomponents via Liquid-Phase Multiphoton Direct Laser Writing: A Review

We present an overview of functional metallic microstructures fabricated via direct laser writing out of the liquid phase. Metallic microstructures often are key components in diverse applications such as, e.g., microelectromechanical systems (MEMS). Since the metallic component’s functionality mostly depends on other components, a technology that enables on-chip fabrication of these metal structures is highly desirable. Direct laser writing via multiphoton absorption is such a fabrication method. In the past, it has mostly been used to fabricate multidimensional polymeric structures. However, during the last few years different groups have put effort into the development of novel photosensitive materials that enable fabrication of metallic—especially gold and silver—microstructures. The results of these efforts are summarized in this review and show that direct laser fabrication of metallic microstructures has reached the level of applicability.
Efficacy of the Spanish modified Story Memory Technique in Mexicans with multiple sclerosis: A pilot randomized controlled trial.

BACKGROUND Memory impairments commonly afflict individuals with MS. While evidence-based cognitive rehabilitation treatments are available in English, the lack of such interventions in Spanish is an important barrier to care for Hispanics with MS. There is class I evidence that the modified Story Memory Technique (mSMT) improves learning in English. This intervention has been translated and adapted into Spanish. OBJECTIVE To examine the preliminary efficacy of the Spanish mSMT to improve learning in Mexicans with MS. METHODS Twenty individuals with relapsing-remitting MS were randomized to treatment (n = 10) or placebo control (n = 10) groups. The Spanish mSMT is a 10-session intervention teaches imagery and context to facilitate learning. The control condition was matched to the treatment condition in treatment duration, and stimulus content and presentation. Participants completed baseline and post-treatment neuropsychological assessments. RESULTS Individuals who received the Spanish mSMT showed significant improvements in learning and life satisfaction relative to the control group. Also observed were a near-moderate effect size on perceived memory complaints and a moderate-to-large effect size on the family's perception of the patient's competency. CONCLUSIONS The Spanish mSMT showed preliminary efficacy in improving learning deficits in Mexicans with MS, and such improvements may extend to other domains.
Iron nanoparticle-labeled murine mesenchymal stromal cells in an osteoarthritic model persists and suggests anti-inflammatory mechanism of action

Osteoarthritis (OA) is characterized by cartilage degradation and chronic joint inflammation. Mesenchymal stem cells (MSCs) have shown promising results in OA, but their mechanism of action is not fully understood. We hypothesize that MSCs polarize macrophages, which are strongly associated with joint inflammation to more homeostatic sub-types. We tracked ferumoxytol (Feraheme™, iron oxide nanoparticle)-labeled murine MSCs (Fe-MSCs) in murine OA joints, and quantified changes to joint inflammation and fibrosis. 10-week-old C57BL/6 male mice (n = 5/group) were induced to undergo osteoarthritis by destabilization of medical meniscus (DMM) or sham surgery. 3 weeks post-surgery, mice were injected intra-articularly with either fluorescent dye-(DiR) labeled or DiR-Fe-MSC or saline to yield 4 groups (n = 5 per group for each timepoint [1, 2 and 4weeks]). 4 weeks after injection, mice were imaged by MRI, and scored for i) OARSI (Osteoarthritis Research Society International) to determine cartilage damage; ii) immunohistochemical changes in iNOS, CD206, F4/80 and Prussian Blue/Sca-1 to detect pro-inflammatory, homeostatic and total macrophages and ferumoxytol -labeled MSCs respectively, and iii) Masson’s Trichrome to detect changes in fibrosis. Ferumoxytol-labeled MSCs persisted at greater levels in DMM vs. SHAM-knee joints. We observed no difference in OARSI scores between MSC and vehicle groups. Sca-1 and Prussian Blue co-staining confirmed the ferumoxytol label resides in MSCs, although some ferumoxytol label was detected in proximity to MSCs in macrophages, likely due to phagocytosis of apoptotic MSCs, increasing functionality of these macrophages through MSC efferocytosis. MRI hypertintensity scores related to fluid edema decreased in MSC-treated vs. control animals. For the first time, we show that MSC-treated mice had increased ratios of %CD206+: %F4/80+ (homeostatic macrophages) (p<0.05), and decreased ratios of %iNOS+: %F4/80+ macrophages (p<0.01), supporting our hypothesis that MSCs may modulate synovial inflammation.
Comparative Effectiveness of an Interdisciplinary Pain Program for Chronic Low Back Pain, Compared to Physical Therapy Alone.

STUDY DESIGN This is an observational cohort study. OBJECTIVE The aim of this study was to compare the effectiveness of PT to an interdisciplinary treatment approach in patients with chronic low back pain (CLBP). SUMMARY OF BACKGROUND DATA CLBP is a costly and potentially disabling condition. Physical therapy (PT), cognitive behavioral therapy, and interdisciplinary pain programs (IPPs) are superior to usual care. Empirical evidence is lacking to clearly support one treatment approach over another in patients with CLBP. METHODS One hundred seventeen adult patients who completed an IPP for individuals with ≥3 months of back pain were compared to 214 adult patients with similar characteristics who completed PT. The Modified Low Back Pain Disability Questionnaire was the primary outcome measure. Additional measures included: PROMIS physical function, global health, social role satisfaction, pain interference, anxiety, fatigue, sleep disturbance, and Patient Health Questionnaire. Patients who completed the IPP were matched by propensity score to a historical control group of patients who completed a course of PT. Change in functional disability was compared between IPP patients and matched controls. Patient-reported outcome measures were assessed pre to post participation in the IPP using paired t test and by calculating the proportion with clinically meaningful improvement. RESULTS Propensity score matching generated 81 IPP and 81 PT patients. Patients enrolled in the IPP had significantly greater improvement in MDQ scores upon completion compared to patients in PT (15.8 vs. 7.1, P < 0.001). The majority of IPP patients reached the threshold for clinically meaningful change of ≥10 point reduction (60.5%) compared to 34.6% of PT patients, P < 0.01. Patients in the IPP also showed statistically and clinically significant improvement in social role satisfaction, fatigue, and sleep disturbance. CONCLUSION CLBP patients in an IPP demonstrated greater functional improvements compared to similar patients participating in PT. LEVEL OF EVIDENCE 3.
The Phylogeny and Biological Function of Gastric Juice—Microbiological Consequences of Removing Gastric Acid

Gastric juice is a unique combination of hydrochloric acid (HCl), lipase, and pepsin. Acidic gastric juice is found in all vertebrates, and its main function is to inactivate microorganisms. The phylogenetic preservation of this energy-consuming and, at times, hazardous function (acid-related diseases) reflects its biological importance. Proton pump inhibitors (PPIs) are one of the most widely used drugs in the world. Due to the reduced prevalence of Helicobacter pylori infection as well as the increased use of inhibitors of gastric acid secretion, the latter has become the most important cause of gastric hypoacidity. In the present manuscript, we review the microbiological consequences of removing gastric acidity. The resulting susceptibility to infections has not been studied extensively, and focus has mainly been restricted to bacterial and parasitic agents only. The strongest evidence concerning the relationship between hypochlorhydria and predisposition to infections relates to bacterial infections affecting the gastrointestinal tract. However, several other clinical settings with increased susceptibility to infections due to inhibited gastric acidity are discussed. We also discuss the impact of hypochlorhydria on the gut microbiome.