Miracle-dz/UniFAR-FTUs huggingface dataset:
Genome-wide SNP analysis reveals population structure and demographic 2 history of the Ryukyu Islanders in the southern part of the Japanese Archipelago 3

2 The Ryukyu Islands are located to the southwest of the Japanese Archipelago. 3 Archaeological evidence has revealed the existence of prehistoric cultural 4 differentiation between the northern Ryukyu islands of Amami and Okinawa, and the 5 southern Ryukyu islands of Miyako and Yaeyama. To examine a genetic subdivision in 6 the Ryukyu Islands, we conducted genome-wide SNP typing of inhabitants from the 7 Okinawa Islands, the Miyako Islands, and the Yaeyama Islands. Principal component 8 and cluster analyses revealed genetic differentiation between the inhabitants of the 9 Okinawa and Miyako, as well as more recent migration from the Okinawa Islands to the 10 Yaeyama Islands. No genetic affinity was observed between aboriginal Taiwanese and 11 any of the Ryukyu populations. The genetic differentiation observed between the 12 inhabitants of the Okinawa Islands and the Miyako Islands is likely to have arisen due 13 to genetic drift rather than admixture with people from neighboring regions. Based on 14 the observed genetic differences, the inhabitants of Okinawa and Miyako islands are 15 considered to have separated during the Holocene. These findings suggest that the 16 Pleistocene inhabitants, whose bones have been found on the southern Ryukyu Islands, 17 did not make a major genetic contribution, if any, to the present-day inhabitants of the 18 southern Ryukyu Islands. 19
Microcontroller Based Smart Helmet for Coal Miners Safety

: This paper tends to the supervision system of miners in order to detect hazardous events that occur in the mining environment. The problem addressed in this paper include gas poisoning, helmet removal and object fall which can sustained a life threatening injury. In mining industry harmful gases like SO2, CO and NO2 occurs which can causes suffocation. Death of minors mainly causes due to object fall if proper treatment is not provided . Helmet removal is also a dangerous. This paper tends to develop a wireless sensor network to monitor real time situation of underground mines from base station. It gives surveillance with early warning intelligence of harmful gases. So to detect all these, we are using air quality sensor, accelerometer, Infra-red (IR) sensor. These are connected to the RF module. This module does all processing and also controls wireless communication between separate helmet using Contiki operating system. Microcontroller AVR-ATMEG 16 is used as analog to digital converter. All sensors have some threshold value if they cross that value then buzzer will automatically on and status will display on LCD. and reliability. A microcontroller is used for collecting data and making decision, based on which the mine worker is informed through alarm as well as voice system. proposed gas monitoring system plays a vital role in monitoring the gases in the mines. This work includes designing and implementation of a system that continuously monitors the concentration of methane (CH4) and carbon-monoxide (CO) gas in the underground mines, which automatically cuts off the power supply of the particular zone in an underground mine, when the concentration of CH4 exceeds more than the permissible limit decided by the user. For better accuracy, we propose the cross checking of the concentration of the gases from two or more sensors. The present work is devoted on the designing part of the sensor circuit which is dedicated for the better safety environments and need of the miners and mining area. This scheme used intelligent helmets as voice terminal and ultra-low-power nodes of wireless sensor network. The programme adopted ZigBee wireless technology to build wireless sensor networks, realized real-time surveillance with early-warning intelligence on
Dual Mass Flywheel Parameter Identification

Abstract Reducing emissions brings changes in the design of internal combustion engines and thus new challenges for dual-mass flywheels (DMF) in terms of Noise Vibration and Harshness (NVH). The first part of the article describes a simple model of a centrifugal pendulum. Consequently, a more complicated DMF dynamic model involves friction between the spring components. The second part of the article deal with the multibody model of DMF using a CAD model. The dynamic model consists of a torsion spring and two bodies. The model is compared with the experimental method, which is also described in the paper.
SWIM: Social Welfare Maximizing Incentive Mechanism for Smart Meter Data Aggregation

—In spite of many beneﬁts, e.g., energy and communication cost efﬁcient data aggregation, in-network data aggregation network in the smart meter network involves some smart meters acting as relays. Unlike wireless sensor networks (WSNs), the aggregator in the smart meter network cannot assign smart meters as a relay at its will, unless it properly rewards them. Therefore, to encourage users to contribute their smart meters to be used as relays, we introduce an incentive mechanism for the smart meter data aggregation. Unlike the existing incentive mechanisms where the value of completing a requested task is assumed to be ﬁxed regardless of who takes the requested task, we formulate the winner selection problem by incorporating an additional value that depends on who takes the task. Based on the additional value, called “derivative value”, we propose a Social Welfare maximizing Incentive Mechanism (SWIM) for the smart meter data aggregation. SWIM not only encourages users to contribute their smart meters to be used as relays by rewarding them with incentives, but also enhances overall satisfaction of participating smart meters by maximizing the social welfare of the system. Simulation results show that SWIM achieves better social welfare of the system and utility of the aggregator compared with the existing incentive mechanisms.
A Sobolev-type upper bound for rates of approximation by linear combinations of plane waves

: Rates of approximation of smooth functions of d variables by linear combinations of n characteristic functions of half-spaces are investigated. It is shown that functions from balls in Sobolev seminorm (cid:107) . (cid:107) d, 1 , ∞ can be approximated within k d / √ n , where k d as a function of d is decreasing exponentially fast. The upper bound on rates of approximation is obtained from comparison of balls in Sobolev seminorm (cid:107) . (cid:107) 1 ,d, ∞ (deﬁned as the maximum of the L 1 -norms of the d -th derivatives of f ) and a norm called variation with respect to half-spaces. It is shown that if f is any function on (cid:60) d ( d odd) with all partial derivatives of order up to d + 1 vanishing suﬃciently rapidly at inﬁnity, then variation with respect to half-spaces of f is at most k d times (cid:107) f (cid:107) 1 ,d, ∞ . The result are applied to the Gaussian function exp( (cid:107) x (cid:107) 2 ) , its variation with respect to half-spaces is estimated from above by 2 d.
Simulation of Convective Drying with Shrinkage using the Finite Window Method: Application and Validation

This work presents the simulation of drying with shrinkage by the finished window method. To do this, we recalled the drying balance equations and expressed the shrinkage that a product undergoes during the process of product dehydration by means of the shrinkage rate. Then presented the method of resolution employed with an application to the drying of cocoa beans. The different profiles obtained in terms of temperature, water content and volume shrinkage have been shown to be in perfect agreement with the literature. The comparison of the results of the present study with the experimental data of Koua and al., (2019) presents an average relative error of 2.89% for the water content and 0.99% for the reduced volume. The theoretical results are in perfect agreement with the experiments, which gives us a validation criterion of the method proposed as suitable for the resolution of the drying equations.
Identification of manual control behaviour to assess rotorcraft handling qualities

Flight safety has been a fundamental aspect of aircraft, and the future demand for wider usage of aerial operations leads to more focus on the flight safety. Particularly rotorcraft require high standards of flight safety due to their inherent features, such as complicated rotary mechanisms, close-to-ground operations, and complex aerodynamic environment. Consequently, rotorcraft pilots need to exert relatively high workload to safely operate these vehicles. An understanding of the interaction between the rotorcraft and the pilot is essential for improving flight safety. This interaction is elaborated by the Handling Qualities (HQ) discipline, which aims to identify and, if possible predict any deficiency in HQ that could potentially jeopardize safe flight. A typical (and potentially catastrophic) example of a HQ deficiency are the Aircraft / Rotorcraft Pilot Couplings (A/RPC), formerly referred to as Pilot Induced Oscillations (PIO). A/RPC is defined as the involuntary and adverse interaction between the pilot and the vehicle under control. Generally for rotorcraft, the ‘vehicle’ part of this interaction is evaluated by objective HQ criteria and online Rotorcraft Pilot Coupling (RPC) detection tools, whereas the ‘pilot’ part is assessed with subjective pilot ratings. Using subjective ratings has several disadvantages, such as being used at very late stages of the design when a prototype vehicle is already built. Addressing a serious HQ deficiency after this late design stage then requires immerse effort to re-design the vehicle systems and repeat the flight tests.
Co-Optimization of Distributed Renewable Energy and Storage Investment Decisions in a TSO-DSO Coordination Framework

As Distributed Energy Resources (DER) penetration levels and distributed flexibility investments are continuously growing, various smart grid actors need to coordinate their decisions towards optimal DER siting and sizing: First, profit-based Energy Service Providers (ESPs) want to secure their long-term profits and avoid economically unsustainable DER investments. Second, Distribution System Operators (DSOs) need to ensure the reliable operation of their networks in an economically optimal way. Third, Transmission System Operators (TSOs) want to optimally exploit the available “clean” DERs in close collaboration with the downstream DSOs. In this paper, we propose a novel ESP-DSO-TSO coordination scheme to co-optimize distributed renewable energy and storage planning at the distribution network level, while modeling the coordinated TSO-DSO operations. We formulate a bi-level program, the upper-level of which minimizes the DSO's costs, ensuring a minimum rate of return on ESP's investments, while the lower-level models the transmission network-constrained wholesale market. A nested decomposition technique is used to achieve computational tractability. Simulation results showcase a trade-off analysis between sustainable DER investments and system cost minimization and prove that an ESP-DSO-TSO interaction can benefit all involved actors to a certain extent. Finally, the computational efficiency of the proposed nested decomposition algorithm is demonstrated via numerical results.
Immune deficiencies , infection , and systemic immune disorders Defective calcium signaling and disrupted CD 20 – B-cell receptor dissociation in patients with common variable immunodeficiency disorders

Background: B cells of patients with common variable immunodeficiency (CVID) disorders display impairment in production of immunoglobulin class-switched antibodies, which is possibly contributed to by defects in early B-cell activation. On resting B cells, B-cell receptors (BCRs) are organized in oligomers that are signaling inactive. Their triggering by cognate antigen causes the lateral reorganization of BCRs and associated proteins into signalosomes, resulting in BCRactivated calcium entry. In resting cells the B-cell surface antigen CD20 is associated with the BCR but dissociates on signalosome formation. Objective: We sought to determine whether CD20 dissociation from the BCR during early B-cell activation might contribute to the development of CVID disorders. Methods: We evaluated BCR signalosome formation, internalization, and signaling in primary B cells of pediatric patients with CVID disorders and healthy control subjects. Results: In many pediatric patients with CVID disorders, B cells exhibit significant deficits in BCR triggering–mediated calcium entry in the cytosol, which correlates with impaired plasmablast differentiation in vitro. These alterations did not originate from upregulation of CD22 or defects in calcium channels and did not involve gene mutations in phospholipase Cg2 or Bruton tyrosine kinase. Instead, B cells from patients with CVID disorders exhibited reduced BCR dissociation from CD20. BCR or CD20 cross-linking induced less BCR internalization, and antibody-mediated CD20 triggering elicited less BCR downstream signaling, as measured based on secondary fluxes. Conclusions: We propose that CD20 dissociation from the BCR signalosome is pivotal to BCR-mediated calcium mobilization in the cytosol. Defects in CD20/BCR signalosome conformation
Effector Cell Functions Anergic, Autoreactive T Cells to Acquire A Signal through OX40 (CD134) Allows

To study mechanisms of peripheral self-tolerance, we injected small numbers of naive CD4 (cid:1) TCR-transgenic T cells into mice expressing the MHC/peptide ligand under the control of an MHC class II promoter. The donor T cells expand rapidly to very large numbers, acquire memory markers, and go out into tissues, but the animals remain healthy, and the accumulated T cells are profoundly anergic to restimulation with Ag in vitro. Provision of a costimulatory signal by coinjection of an agonist Ab to OX40 (CD134), a TNFR family member expressed on activated CD4 T cells, results in death of the mice within 12 days. TCR-transgenic T cells recovered at 5 days from anti-OX40-treated mice have a unique phenotype: they remain unresponsive to Ag in vitro, but they are larger, more granular, and strongly IL-2R positive. Some spontaneously secrete IFN- (cid:2) directly ex vivo, and the majority make IFN- (cid:2) in response to PMA and ionomycin. Although they are anergic by conventional tests requiring Ag recognition, they respond vigorously to cytokines, proliferating in response to IL-2, and secreting IFN- (cid:2) when TCR signaling is bypassed with IL-12 and IL-18. We conclude that the costimulatory signal through OX40 allows otherwise harmless, proliferating, autoreactive T cells to acquire effector cell functions. The ability of these T cells to respond to cytokines by synthesizing additional inﬂammatory cytokines without a TCR signal may drive the fatal pathogenic process in vivo. The Journal of Immunology, 2004, 172: 6735– 6743.
IMPACT OF PHOSPHOINOSI TIDES ON REGUL ATION OF K-ATP BY ATP AND HYDROGEN SULFIDE

IMPACT OF PHOSPHOINOSITIDES ON REGULATION OF KATP BY ATP AND HYDROGEN SULFIDE Tyler Hendon, B.S. in Biochemistry A thesis submitted in partial fulfillment of requirements for the degree of Master of Science at Virginia Commonwealth University. Virginia Commonwealth University, 2018 Director: Dr. Diomedes Logothetis, Professor, Department of Physiology and Biophysics at Virginia Commonwealth University (Formerly) / Department of Pharmaceutical Sciences at Northeastern University (Presently) Hydrogen sulfide (H2S) reduces ischemia reperfusion (IR) injury by stimulating adenosine triphosphate (ATP) sensitive potassium channels (KATP) . Demonstrating H2S stimulation is unique to KATP, as other inwardly rectifying potassium (Kir) channels demonstrate inhibition or are unaffected . We recently showed that H2S inhibits Kir2 and Kir3 by decreasing channel sensitivity to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2 or PIP2) . Here, we test the hypothesis that H2S regulation of Kir6.2, a poreforming subunit of the KATP channel, is also dependent on PIP2. Using whole-cell patchclamp we show that H2S increases the activity of Kir6.2 channels expressed in HEK-293 cells. To study the mechanism, we modulated PIP2 levels by expressing a lightactivated phosphatase, or by including high levels of a water-soluble PIP2 analog in the patch pipette. The results suggest that H2S augmentation of Kir6.2 channel activity is increased when PIP2 levels are elevated.
E-Voting Authentication based on Tactile Internet and Blockchain Technology

E-voting requires entrance of large numbers of citizens simultaneously in a relatively small time. This may cause slowness or unavailability of the service in the worst case. Authentication of large-scale e-voting is still an issue that needs more security and privacy. Moreover, there are many developments in the internet culminating to internet-of-things and anticipating reaching to Tactile Internet with fifth generation (5G) mobile networks. However, implementing e-voting according to this new technology imposes many challenges. This paper presents a proposed authentication architecture that assumes the existence of Tactile Internet as a futuristic infrastructure and the blockchain as a solution for maintaining security. The proposed architecture technically provides two modes of operation: mobile phone and virtual reality (VR) lenses. The gained results of e-voting authorization are proved to be applicable with higher accuracy.
INHIBITION OF MYCOTOXIN-PRODUCING FUNGI ISOLATED FROM KARISH CHEESE BY LACTOBACILLI STRAINS

Food- borne fungi cause serious spoilage and some species can produce toxic metabolites (mycotxins), produce serious health problems. Fungi were isolated from forty samples of fresh Karish cheese, collected from Giza governorate, using malt extract and potato dextrose agar media at 25 Ο C. The results indicate that members of Penicillum spp . and Aspergillus spp . were the mainly contaminated molds of all the tested samples. Members of Penicillum spp . ( P. roqueforti , P.corylophilum and P. chrysogenum ) and Aspergillus spp. ( A. flavus and A. niger ). Spectrum of antifungal activity of Lactobacillus casei CH-1, L. bulgaricus CH-2 and L. plantarum (ATCC 8014) were investigated. Among tested strains L.plantarum (ATCC 8014) strain had a strongest inhibitory activity against all isolated of molds from Karish cheese samples. The disc diffusion method was used to evaluate the zone of fungal growth inhibition at various volume of cell-free supernatant. Minimal inhibition concentration (MIC) and minimal fungicidal concentration (MFC) of cell-free supernatant were determined. Cell-free supernatant of L.plantarum (ATCC 8014) culture in Karish cheese was studied. No moldes could be observed till 30 days of storage. Therefore, addition of cell-free supernatant from L.plantarum (ATCC 8014) to Karish cheese is a good biopreservatives, preventing fungal spoilage and consequently mycotoxin formation in Karish cheese and recommended to extent the shelf life. investigate the antifungal activity of Lactobacilli strains against some mycotoxin-producing fungi isolated from Karish cheese Lactobacilli strains.
Institutional Knowledge at Singapore Management University Processing long queries against short text: Top-k advertisement matching in news stream applications

Many real applications in real-time news stream advertising call for efﬁcient processing of long queries against short text. In such applications, dynamic news feeds are regarded as queries to match against an advertisement (ad) database for retrieving the k most relevant ads. The existing approaches to keyword retrieval cannot work well in this search scenario when queries are triggered at a very high frequency. To address the problem, we introduce new techniques to signiﬁcantly improve search performance. First, we devise a two-level partitioning for tight upper bound estimation and a lazy evaluation scheme to delay full evaluation of unpromising candidates, which can bring three to four times performance boosting in a database with 7 million ads. Second, we propose a novel rank-aware block-oriented inverted index to further improve performance. In this index scheme, each entry in an inverted list is assigned a rank according to its importance in the ad. Then, we introduce a block-at-a-time search strategy based on the index scheme to supportamuchtighterupperboundestimationandaveryearlytermination.Wehaveconductedexperimentswithrealdatasets,andtheresultsshowthattherank-awaremethodcanfurtherimproveperformancebyanorderofmagnitude.
PNA-DNA Hybridization Detection with One-Step Electrodeposition using Nanomaterial Modified Gold Electrode

One of the important parameter that plays an important role in the performance of an electrochemical DNA biosensor is the supporting material for the immobilized probes. Using nanomaterials for electrode modification has gained a lot of attention with many advantages, such as large surface area and good electrical conductivity that can improve sensor sensitivity. The development of a direct PNA-DNA hybridization detection based on a novel pyrrolidinyl peptide nucleic acid or acpcPNA probe was studied using differential pulse voltammetric detections. Enhancement the sensitivity of DNA hybridization biosensor is presented using nanomaterial modified gold electrode. The oxidation current of an anthraquinone (AQ) tagged acpcPNA probe (acpcPNA-AQ) was measured from the electron transfer between the tagged AQ and the gold electrode based on differential pulse voltammetry (DPV). From various gold modified electrodes, polyaniline-Graphene-Ag nanocomposite coated electrode surface provided a higher sensitivity than polyaniline, polyaniline-Graphene and polyaniline-Ag due to its high surface area and good electrical conductivity of graphene and Ag nanoparticles. This DNA sensor can be used up to 33 times with 0.05 M of sodium hydroxide as the regeneration solution. Moreover, only one-step of electrodeposition of nanomaterial modification is very simple, cost-effective and fast detection of a specific DNA screening technique.
DOCKING STUDY OF MOLECULAR MECHANISM BEHIND THE QUERCETIN INHIBITION OF MYCOBACTERIUM TUBERCULOSIS UREASE

especially His 533) cause steric hindrance for the flap transition from open to closed conformation thus fixing it in the open state that blocks catalysis. Our model of quercetin binding to MTU corresponds to the results of Xiao Z. -P. et al. which showed by enzyme kinetics and molecular docking that quercetin is a noncompetitive inhibitor of Helicobacter pylori urease and it is positioned near the active site flap as well blocking it in the open conformation. As well, our model of quercetin binding to urease corresponds to the results of Macomber L. et al. which showed by docking that quercetin binds to the flap region of Klebsiella aerogenes urease. However, our model disagrees with the proposed general mechanism of urease inhibition by aromatic poly-hydroxylated inhibitors through the covalent binding with Cys residue of the flap covering the active site. It may be a consequence of the limitation of molecular docking methods used in our study that can explore only non-bound interactions. Conclusions. molecular binding MTU corresponds to the results of docking studies on quercetin binding to the the