Miracle-dz/UniFAR-FTUs huggingface dataset:
European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by representatives of nine societies and by invit

Authors/Task Force Members: Ian Graham1*, Chairperson, Dan Atar1, Oslo (Norway), Knut Borch-Johnsen2,3, Gentofte (Denmark), Gudrun Boysen4, Copenhagen (Denmark), Gunilla Burell5, Uppsala (Sweden), Renata Cifkova6, Praha (Czech Republic), Jean Dallongeville1, Lille (France), Guy De Backer1, Gent (Belgium), Shah Ebrahim1, London (UK), Bjørn Gjelsvik7, Oslo (Norway), Christoph Herrmann-Lingen5, Marburg (Germany), Arno Hoes7, Utrecht (The Netherlands), Steve Humphries1, London (UK), Mike Knapton8, London (UK), Joep Perk1, Oskarshamn (Sweden), Silvia G. Priori1, Pavia (Italy), Kalevi Pyorala1, Kuopio (Finland), Zeljko Reiner9, Zagreb (Croatia), Luis Ruilope1, Madrid (Spain), Susana Sans-Menendez1, Barcelona (Spain), Wilma Scholte op Reimer1, Rotterdam (The Netherlands), Peter Weissberg8, London (UK), David Wood1, London (UK), John Yarnell1, Belfast (UK), Jose Luis Zamorano1, Madrid (Spain)
New Directions in Justification Logic

Justification logics are constructive analogues of modal logics. As such, they provide perspicuous models of those modalities that have inherently constructive character, such as intuitionistic mathematical provability or the knowledge operator of evidentialist epistemology. In this dissertation, I examine a variety of positions in epistemology, along with their associated ontological commitments, and develop various classical and non-classical justification logics that are suitable for use as models of these positions. New Directions in Justification Logic
Mandibular metastasis with pulmonary cannon balls: Presentation of follicular carcinoma thyroid

Swelling of the jaw due to metastatic lesions needs careful search for an occult malignancy. Thyroid carcinoma is a rare cause of jaw bone metastasis. A 70-year-old female presented in our chest clinic with progressive shortness of breath for last 1-month and associated painful swelled right jaw for last 4 months. Her computed tomography scan thorax showed bilateral cannon ball metastasis involving all lobes of the lung. Fine-needle aspiration cytology (FNAC) from radiographically evident osteolytic lesion of the mandible was suggestive of metastatic carcinoma probably of thyroid origin. Ultrasonography of the thyroid gland revealed well-defined hypoechoic nodule (measuring about 2 cm × 1.8 cm) with few foci of calcification. FNAC from the thyroid nodule followed by immunocytochemistry was suggestive of follicular carcinoma of the thyroid. We report a very rare presentation, as jaw metastasis in follicular carcinoma of the thyroid.
Small world models and a compact routing scheme

Small world networks generative models are randomized alternatives of network building where nodes are interconnected by small paths. In this context, a small path has the length given by a logarithmic function in the size of the network. Applications in peer-to-peer networks, wireless sensors and networks on chip are some computational examples that use networks generated by small world mathematical models. This work presents the undirected toroidal small world networks model (UTSW). The model generates a base two-dimensional grid to model the clustering of the nodes, and random connections to model small paths. The presence of small paths does not imply in the existence of a message routing algorithm that finds them. However, there is a greedy routing algorithm in the literature that finds small paths in UTSW networks, where a small path has the length given by a polylogarithmic function in the size of the network. The octahedral small world model (OSW) is also presented. It generates a base planar graph on the octahedron, which is proved to be similar to the generating on spheres. Then, it simulates people and neighborhoods on the surface of the planet. The OSW model also generates random connections to model small paths. A routing algorithm that routes messages through small paths is also defined for this model. Both routing algorithms use the greedy paradigm and decide to which neighbor to forward a message with only the information in the routing table of the node. These algorithms require small amount of memory per node, find small paths and execute in constant time, in both presented models. So, they are good options in routing, besides the routing thought shortest paths. However, both require positioning information generated by the mathematical model. In the case of UTSW model, each node has an ordered pair of natural numbers that positions it on the two-dimensional lattice. Finding these positions when they are unknown is challenging because the randomly generated connections make the grid identification difficult. However, the random connection of a node breaks the lattice pattern in its neighborhood with small probability. This topological property of UTSW networks motivated the design of a labeling algorithm that finds the positions in the lattice with high probability. It executes a local search on each node and removes the random connection if it is identified. After the sweeping, the algorithm executes a global breadth-first search on the resulting network, positioning each node based on the already found positions of its neighbors. A compact routing scheme for UTSW graphs is then presented. It consists of a preprocessing algorithm that uses the labeling algorithm to generate logarithmic size data structures for all nodes and executes in linear time on the size of the network. Thus, the greedy routing algorithm routes messages using the data structures generated by the preprocessing algorithm.
Health Care USA: Understanding Its Organization and Delivery

This eighth edition has been thoroughly revised to reflect recent developments in this dynamic industry. In addition to updating all key financial, utilization, and other data with the latest available information, it includes: New chapter on health information technology Thoroughly revised chapter on mental health services including a new discussion of preventive behavioral services, and recent developments from the “Freedom Commission on Mental Health” Discussions of the impacts of the American Reinvestment and Recovery Act of 2009 (ARRA) and Patient Protection and Affordable Care Act of 2010 (ACA). "Key Terms for Review" at the conclusion of each chapter
Evaluation of Hyperbaric Oxygen Therapy for the Treatment of Sudden Hearing Loss in Both Primary and Secondary Cases

This retrospective study included 256 cases with sudden hearing loss treated by hyperbaric oxygen therapy (HBO) in our hospital from 2000 to 2006 (57 primary cases with intravenous steroid administrations, and 199 secondary cases after insufficient effects of initial steroid therapy). Hearing thresholds were ascertained at frequencies of 250, 500, 1000, 2000, and 4000 Hz using pure-tone audiometry. To establish the indication of secondary HBO therapy for the treatment of sudden hearing loss, several prognostic factors including initial average hearing thresholds, age, intervals between the onset and beginning of HBO treatment, and the presence or absence of vertigo at onset were evaluated between primary and secondary cases. Although the HBO effects in the secondary were poorer than those in primary cases, one third of the secondary cases indicated hearing threshold gains of over 10 dB. Regardless of an age over 60 years, the presence of vertigo, and/or poor initial average hearing levels, HBO is considered to be an effective choice for secondary therapy of sudden hearing loss in patients within 8 weeks after onset.
Four Cases of Unusual Complete Cervical Ribs Articulating With the Hypertrophied Scalene Tubercle With Different Clinical Presentations

Thoracic outlet syndrome (TOS) is defined as the signs and symptoms caused by compression of brachial plexus and subclavian vessels in the cervicoaxillary region. Cervical ribs are very rare causes of TOS. Most of them are asymptomatic and incidentally diagnosed during routine chest x-ray. We presented here 4 cases of unusual cervical ribs articulating with hypertrophied scalene tubercle with different clinical presentations including: TOS, palpable mass at the supraclavicular region, and asymptomatic. TOS was treated surgically with good results. In conclusion, complete cervical costa, articulating with hypertrophied scalene tubercle is a very rare cause of TOS. Scalenotomy and complete resection of the cervical rib is a good choice for treatment. In addition, the cervical ribs should be considered in the differential diagnosis of the palpable masses seen at the supraclavicular regions. Plain radiographs are enough for diagnosis; however, 3-dimensional computerized tomography provides many advantages in preoperative surgical planning and demonstrating the articulating structure of the cervical ribs in a detailed manner.
AB0465 Clinical Efficacy of the Synthetic Anti-Rheumatic Drug, Iguratimod

Background Iguratimod (IGU) is newly synthetic DMARDs and under clinical use to the rheumatoid arthritis (RA) patients from 2012 in Japan. Objectives We examined the effects of the IGU therapies for RA patients in our hospital. Methods Forty one (15 males;16 females) patients who started receiving IGU from September, 2012 to April, 2013 in our hospital, were included in this study. The age of this cohort was 68.9±10.9 years, and the disease duration was 14.7±12.7 years. Methotrexate (MTX) combination rate was 59.2%, the mean dose of MTX; 9.0±3.1 mg/week, PSL combination rate; 52.4% and the amount of PSL; 4.9±2.6 mg/day. The biological drugs were administered to seven patients. During 12 weeks prior to the initiation of the IGU therapies and 24 weeks after IGU administration, there was not any change of drugs and operation procedures. The clinical therapeutic process after the initiation of IGU were analyzed at week 0, 4, 8, 12, 16, 20 and 24 (last observation carried forward: LOCF). Wilcoxon signed-rank test were performed to assess the differences in each parameter. The logistic regression analyses were performed to investigate the parameters associated with the improvement of the disease activity with IGU treatment. Results Before IGU treatment; C-reactive protein (CRP) 1.4±1.7 mg/dl, erythrocyte sedimentation rate (ESR) 51.2±27.9 mm/h, matrix metalloproteinase-3 (MMP-3) 223.5±183.3 ng/ml, Disease activity score assessing 28-joint (DAS28) versions using ESR (4) 5.0±1.7, DAS28 versions using CRP (4) 4.1±1.7, Simplified Disease Activity Index (SDAI) 25.8±19.7 and clinical disease activity index (CDAI) 24.4±19.1. At week 24; CRP 1.1±1.9 mg/dl, ESR 44.3±28.0 mm/h, MMP-3 208.1±255.2 ng/ml, DAS28-ESR (4) 3.9±1.4, DAS28-CRP (4) 3.0±1.3, SDAI 13.0±12.7 and CDAI 11.9±2.0. The DAS28-ESR (4), DAS28-CRP (4), SDAI and CDAI significantly decreased at week 4. All parameters, with exception of MMP-3, were significantly reduced at week 24 of the IGU therapy. Twenty six cases continued the IGU therapies during 24 weeks, and 18 patients achieved the DAS28-CRP remission and 3 patients were classified into the low disease activity (LDA) of the DAS28-CRP (DAS28-CRP <2.7). The DAS28-CRP (4) were significantly reduced at week 4 with (n=24) or without (n=17) the use of MTX (LOCF). In addition, at week 24, DAS28-CRP (4) of each dosage of IGU, 25 mg/day (n=13) or 50 mg/day (n=13), was significantly decreased respectively. DAS28-CRP (4) at week 0 was associated with the achievement of remission or LDA of DAS28-CRP (4) at week 24 (Odds ratio 5.509, p=0.037). Conclusions Our results suggest that IGU is clinically one of the useful synthetic DMARDs to RA patient. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.4917
A Study of Detection of Lung Cancer Using Data Mining Classification Techniques

Lung Cancer is a disease of uncontrolled cell growth in tissues of the lung. Detection of Lung Cancer in its early stage is the key of its cure. In general, a measure for early stage lung cancer diagnosis mainly includes those utilizing X-ray chest films, CT, MRI etc. In many parts of the world widespread screening by CT or MRI is not yet practical, so that chest radiology remains in initial and most common procedure. Firstly, we will use some techniques are essential to the task of medical image mining, Lung Field Segmentation, Data Processing, Feature Extraction, Classification using neural network and SVMs. The methods used in this paper work states to classify digital X-ray chest films into two categories: normal and abnormal. Different learning experiments were performed on two different data sets, created by means of feature selection and SVMs trained with different parameters; the results are
STUDY OF ECG CHANGES IN SMOKERS

This study is intended to evaluate the changes in Electrocardiogram (ECG) in apparently healthy adult male smokers. This cross-sectional study covers 40 smokers, who smoked on an average 10 cigarettes per day for at least 5 years, and 40 non-smokers to find out the possible risk factors for cardiovascular disorders. This study was conducted during April 2011 to April 2012 in the Department of Physiology of Andhra Medical College, on subjects whose age ranged from 20 to 60 years. The ECG results were evaluated for different parameters like heart rate, P-wave, P-R interval, QRS complex, QT interval, and T-wave. The results were analyzed using student's t-test. The probability (p value) was calculated. The analysis showed that QRS and QT interval were shortened and that the QTc interval was widened in the smokers, although the values did not show any statistical significance. From the statistical analysis of the results obtained in the present study and their comparison with those of published reports, it appears that smoking 10 cigarettes per day for 5 Years does not cause major change in ECG wave forms.
Automatic information summary and extraction from construction video monitoring systems

This thesis is protected by copyright, with all rights reserved. By reading and using the thesis, the reader understands and agrees to the following terms: 1. The reader will abide by the rules and legal ordinances governing copyright regarding the use of the thesis. 2. The reader will use the thesis for the purpose of research or private study only and not for distribution or further reproduction or any other purpose. 3. The reader agrees to indemnify and hold the University harmless from and against any loss, damage, cost, liability or expenses arising from copyright infringement or unauthorized usage.
Phosphorus attenuation in streams by water-column geochemistry and benthic sediment reactive iron

Abstract. Streams can attenuate inputs of phosphorus (P) and, therefore the likelihood of ecosystem eutrophication. This attenuation is, however, poorly understood, particularly in reference to the geochemical mechanisms involved. In our study, we measured P attenuation mechanisms in the form of (1) mineral (co-)precipitation from the water-column and (2) P sorption with benthic sediments. We hypothesized that both mechanisms would vary with catchment geology and, further, that P sorption would depend on reactive Fe content in sediments. We sampled 31 streams at baseflow conditions, covering a gradient of P inputs (via land use), hydrological characteristics, and catchment geologies. Geochemical equilibria in the water-column were measured and benthic sediments ( 90 %) and varied with parent geology. Similarly, most sediment Fe was in a recalcitrant form (generally > 90–95 %). However, despite its small contribution to total sediment Fe, the pool of surface-reactive Fe was a strong predictor for sediment P sorption potential. Our results suggest that, in these streams, it is the combination of biogeochemical Fe and P cycles and the exchange with the hyporheic zone that attenuates DRP in baseflow. Such combinations are likely to vary spatiotemporally within a catchment and must be considered alongside inputs of P and sediment if the P concentrations at baseflow – and eutrophication risk – are to be well managed.
Targeted Transdermal Delivery of Curcumin for Breast Cancer Prevention

N.B. This manuscript is based on the research concept submitted to the “Global Challenge to Prevent Breast Cancer” idea showcase and competition, launched in 2018 by the California Breast Cancer Research Program (CBCRP), which was subsequently selected for publication. The hypothesis, methods, and discussion put forth here are thus proposed concept studies, which could eventually be elucidated in the future. Curcumin is an herbal supplement, shown in preclinical studies to have antioxidant, anti-inflammatory, and antitumoral properties that we believe can be harnessed for breast cancer prevention. However, due to its poor absorption when consumed orally, curcumin’s anticancer effects have not yet been exploited to their full therapeutic potential. Incorporating existing research that focuses on the optimization of curcumin’s bioavailability and the latest transdermal delivery technology, we propose, below, a hypothetical in vivo study to test whether a targeted daily dose of bioavailable curcumin has a cytotoxic effect on cancer cells, potentially reducing the incidence of breast cancer over time. Our ultimate objective is to adopt innovative methods to create curcumin-infused bio-textiles offering transdermal, targeted drug delivery, simply through contact with the skin. We would use this fabric to create disposable bra inserts for an effortless, daily breast cancer prevention regimen for healthy women. It would be essential that the cost of these inserts remain reasonable, but if successful, curcumin is readily available, affordable and non-toxic, and could thus be a preventive measure that would be beneficial for women from all socio-economic backgrounds.
Cytochrome P450 Family 1 B1 Gene Mutations in Primary Congenital Glaucoma Affected Egyptian Patients

Aims: Primary congenital glaucoma (PCG) is a leading cause of childhood blindness. The cytochrome P450 family 1, subfamily B, polypeptide 1 (CYP1B1) is the most mutated gene that is associated with PCG. Very few studies have examined the promoter region and exon1 of the CYP1B1 gene. This work was planned to contribute to the description of the possible causative mutations of CYP1B1 gene that are related to PCG affected Egyptian patients. Patients and Methods: Patients diagnosed as glaucomatous based on their symptoms and detailed ophthalmological examinations at the time of presentation underwent an intraocular pressure lowering surgical procedure. Investigations were further proceeded on the molecular level. Sequencing-based mutation screen for the promoter region, exon1 and the coding region of exon3 of CYP1B1 gene have been performed in two related consanguineous PCG affected families and four other sporadic Egyptian patients using the polymerase chain reaction (PCR) assay; where PCR products were sequenced, and further analyzed. Results: Sequencing analysis revealed three novel mutations in PCG affected patients one in the promoter region (g.G2872A) and two in exon1 (g.C3268T and g.C3332T). Two additional mutations in exon3 (p.L432V and p.N453S) reported for the first time in PCG affected Egyptian patients. Clinical and genetic data of the two consanguineous families revealed that although the four parents have the same variations as their sons, they are ophthalmologically free. Conclusion: Regular ophthalmic examinations of siblings and parents of these affected patients should take place for early detection of any form of glaucoma to allow prompt diagnosis and early treatment when needed. Clinical examination and molecular genetic data could contribute to early diagnosis and prevention of the visual impairment caused by PCG. This study provides groundwork for expanded genetic investigations in Egypt paving the way for genetic counseling to help affected families make informed medical and personal decisions.
UXmood - A Sentiment Analysis and Information Visualization Tool to Support the Evaluation of Usability and User Experience

This paper presents UXmood, a tool that provides quantitative and qualitative information to assist researchers and practitioners in the evaluation of user experience and usability. The tool uses and combines data from video, audio, interaction logs and eye trackers, presenting them in a configurable dashboard on the web. The UXmood works analogously to a media player, in which evaluators can review the entire user interaction process, fast-forwarding irrelevant sections and rewinding specific interactions to repeat them if necessary. Besides, sentiment analysis techniques are applied to video, audio and transcribed text content to obtain insights on the user experience of participants. The main motivations to develop UXmood are to support joint analysis of usability and user experience, to use sentiment analysis for supporting qualitative analysis, to synchronize different types of data in the same dashboard and to allow the analysis of user interactions from any device with a web browser. We conducted a user study to assess the data communication efficiency of the visualizations, which provided insights on how to improve the dashboard.
Extraction Of Metabolites And Screening Their Antioxidant Potential From Marine Macro Algae

Antioxidant potential of different extracts of macroalgal species of south east coast of Tamilnadu were examined. The organic solvents such as Acetone, Methanol, Ethanol and Hexane were used to extract the macroalgae such as C. clavulatum, G. edulis of red algae and E. intestinalis belongs to green algae which were taken for the study. Methanolic extracts of the all the test species exhibit high antioxidant activity (DPPH) when compared to other solvents comparing C. clavulatum shows 97% followed by the E. intestinalis 91.17% and G. edulis shows 90.23%. In Hydrogen peroxide scavenging assay Acetone extract of C. clavulatum shows 91.34% followed by G. edulis 90.85% and E. intestinalis 87.59%. Hexane shows maximum activity in FRAP . The results suggest that Methanolic extracts have potent antioxidant ability.
THE PRACTICE OF SELF-INJURY IN YOUNG PEOPLE: A PAIN TO ANALYZE

Pain is an experience considered unpleasant; however, there are situations in which it is self-inflicted. The theme of this work involves the behavior of causing pain through self-injury. Objective: to analyze the phenomenon of self-injury based on the meanings attributed to pain perception by young people who undergo or underwent this experience, besides identifying aspects related to the practice of self-injury. Method: it is a qualitative study, through semi-structured interviews, with 10 young people between 18 and 28 years old, who practice or have already practiced self-injury. The data were analyzed by thematic content analysis technique and interpreted by Freudian psychoanalytic theory. Results: seven categories were identified, however, in this article only the categories “the meanings and senses of pain” and “sensations and feelings” will be discussed. The first category includes the themes “physical pain relieves emotional pain”, “good pain”, “intensity of pain” and “desired pain”. The second category the themes “relief” “anguish”, “guilt”, “sadness” and “anger”. Conclusion: self-injury seems to be a discharge of unbearable psychic contents and provides relief from psychic suffering.