Miracle-dz/UniFAR-FTUs huggingface dataset:
N6-methyladenosine-induced SVIL antisense RNA 1 restrains lung adenocarcinoma cell proliferation by destabilizing E2F1

ABSTRACT Accumulating evidence indicates that N6-methyladenosine (m6A) and long noncoding RNAs (lncRNAs) play crucial roles in cancer development. However, the biological roles of m6A and lncRNAs in lung cancer tumorigenesis are largely unknown. In this study, SVIL antisense RNA 1 (SVIL-AS1) was downregulated in lung adenocarcinoma (LUAD) tissues and was associated with a favorable prognosis in patients with LUAD. SVIL-AS1 overexpression suppressed LUAD cell proliferation and blocked cell cycle arrest. Mechanistically, METTL3 increased the m6A modification and transcript stability of SVIL-AS1. The enhanced SVIL-AS1 expression mediated by METTL3 suppressed E2F1 and E2F1-target genes. Moreover, SVIL-AS1 accelerated E2F1 degradation. The reduction in cell proliferation induced by SVIL-AS1 overexpression could be rescued by E2F1 overexpression or METTL3 knockdown. In conclusion, our work demonstrated the role and mechanism of METTL3-induced SVIL-AS1 in LUAD, which connects m6A and lncRNA in lung cancer carcinogenesis.
Managing change in scheduling data

This paper presents CREWS, an Al-based tool for generating applications in crew scheduling. CREWS addresses both scheduling and rescheduling and focuses on new capabilities of CREWS, in particular, handling changes in data. The main goal was to produce a decision support system in the area of human resource management and provide a system to support the scheduling experts.
What Can We Learn About the Others Present During Incidents of Child Abuse?: Key Lessons and Future Directions Based on a Scoping Review

Child abuse (CA) is a global problem that has received attention from policymakers, researchers, and practitioners. The majority of studies have focused on the phenomenon’s epidemiology and consequences, alongside groundbreaking writing on victims and perpetrators. The concept of others who are present during the abuse is understudied and underdeveloped, despite its vital importance in better understanding children’s experiences as well as their disclosure. The current study was designed to spotlight the phenomenon of others' presence, beyond the victims and perpetrators, during child abuse incidents. The current literature review was guided by a scoping review strategy. The results revealed scant empirical data, with only 15 studies meeting the inclusion criteria of the study. The articles that met the inclusion criteria addressed other people’s presence during CA incidents, were published in peer-reviewed journals, and were written in the English language. These articles’ analyses addressed the relations of the survivors with these others, pointing mainly to two identities: accidental bystanders who are not familiar with the child and family members of the child. The results provided a glance into the process that accidental bystanders go through during the abuse and the meaning of their presence for those who are family members. The perceptions and experiences of the children themselves with respect to the presence of the others during the abuse are noticeably lacking. The key conclusion from the current scoping review pinpoints the urgent need to advance the empirical knowledge on the presence of others during incidents of child abuse, especially others who are familiar to the children and are a significant part of their lives. The conceptualization of this phenomenon has the potential to better adapt prevention and intervention efforts in the field of child abuse.
A computer-assisted methodology to innovate the development process of prosthesis socket

: In this paper we propose a computer-assisted methodology to improve prosthesis development process. We consider the case of the socket (interface between the residual limb and the mechanical part of the prosthesis) both for trans-femoral or trans-tibial amputee since it requires a high level of customisation. The new paradigm forecasts the integration of the following techniques: reverse engineering and medical imaging for the acquisition of patient’s morphology and bony-muscular structure, virtual prototyping to model the limb and the socket, physics-based simulation to reproduce the real movement of the patient and the interaction between the socket and stump and, finally, rapid prototyping tools for the physical realization of the product. The paper describes problems related to the implementation of each step within a real socket development process; in particular, first results regarding the reconstruction of the stump virtual model and physics-based simulation will be presented and discussed.
The effect of the rural mystique on community attachment, community satisfaction, perceived influence in community decision-making, and self-reported engagement in community-oriented actions

ABSTRACT Endorsement of the positive imagery of rurality and rejection of the negative representations of rural life is commonly referred to in the literature as the rural mystique. Using data collected in a 2012 survey of persons living in small and rural places in Texas, we tested the hypothesis that increased acceptance of the rural mystique is positively associated with community attachment, community satisfaction, perceived influence in community decision-making, and self-reported engagement in community-oriented actions. Bivariate and multiple correlation-regression analyses provided moderate support for our proposition. Rural and small-town residents’ endorsement of the rural mystique was associated with their levels of community attachment, community satisfaction, and perceived influence in community decision-making. Acceptance of the rural mystique was not statistically related to respondents’ self-reported engagement in community-oriented actions. The findings also revealed that certain sociodemographic variables are independently and statistically related to one or more of the four dependent variables.
Imbalance of Neuregulin1-ErbB2/3 signaling underlies altered myelin homeostasis in models of Charcot-Marie-Tooth disease type 4H

Charcot Marie Tooth disease (CMT) is one of the most common inherited neurological disorders, affecting either axons from the motor and/or sensory neurons or Schwann cells (SC) of the peripheral nervous system, and caused by more than 100 genes. We previously identified mutations in FGD4, as responsible for CMT4H, an autosomal recessive demyelinating form of CMT. FGD4 encodes FRABIN a GDP/GTP nucleotide exchange factor (GEF), particularly for the small GTPase cdc42. Remarkably, nerves from patients with CMT4H display excessive redundant myelin called outfoldings that arise from focal hypermyelination, suggesting that FRABIN could play a role in the control of PNS myelination. To gain insights into the role of FGD4/FRABIN in SC myelination, we generated a knock-out mouse model, with conditional ablation of fgd4 in SC. We showed that the specific deletion of FRABIN in SCs leads to aberrant myelination in vitro, in dorsal root ganglion (DRG)/SCs cocultures as well in vivo, in distal sciatic nerves. We observed that those myelination defects are related to an upregulation of some interactors of the NRG1 type III/ErbB2/3 signaling pathway, which is known to ensure a proper level of myelination in the PNS. Based on a yeast two-hybrid screen, we identified SNX3 as a new partner of FRABIN, which is involved in the regulation of endocytic trafficking. Interestingly, we showed that loss of FRABIN impairs endocytic trafficking which may contribute to the defective NRG1 type III/ErbB2/3 signaling and myelination. Finally, we showed that the reestablishment of proper levels of the NRG1 type III/ErbB2/3 pathway using Niacin treatment reduces myelin outfoldings in nerves of CMT4H mice. Overall, our work reveals a new role of FRABIN in the regulation of NRG1 type III/ErbB2/3 NRG1signaling and myelination and opens future therapeutic strategies based on the modulation of NRG1 type III/ErbB2/3 NRG1to reduce CMT4H pathology and more generally others demyelinating CMT.
High‐resolution synthetic aperture radar based on the IEEE 802.11 protocol

This is a feasibility study for developing low-cost synthetic aperture radar (SAR) systems based on the IEEE 802.11ac protocol. The baseband module of IEEE 802.11ac is found to be similar to SAR, and its frequency coverage is wide enough to meet the requirement of high-resolution SAR imaging. By using the subbands merging technique, the spatial resolution can reach 0.5 m × 0.5 m.
Bayesian Hierarchical Modeling Applied to Test Day Milk Yield Data

Fitting non-linear models to the milk yield records of dairy cows is of particular importance for both breeding and management purposes as they provide a summary of the pattern of milk production with a few parameters that are biologically interpretable in animal science. In this study, hierarchical modeling of the test day milk yield data collected on monthly interval was considered and the non-linear three parameter Wood’s incomplete gamma function was used to obtain the lactation curves of 200 Holstein cows. Bayesian approach was utilized in estimation of model parameters. Some characteristics of lactation such as persistency, peak time and peak yield were also derived as well as total milk yield for each cow.
Agile Software Development Methods, Comparison with Traditional Methods & Implementation in Software Firm

In today’s world business is very much dynamic in nature and organisation are changing their requirements very quickly and for that there is a tremendous importance of agile methods in software development , because of its nature of being fast as compare to traditional method it is used very rapidly in software development process. Though traditional methods like waterfall, object oriented approaches have dominated past decades but Agile software development brings its own set of novel challenges that must be addressed to satisfy the customer through early and continuous delivery of the valuable software . The paper carries the distinct objectives to define current agile method understanding different agile methods, the uses of agile and drawbacks. To meet the set goals and objectives, we used qualitative and research methodologies. Apart from taking references and review, we performed research from a software firm named Incubation Centre which is in Indore.
A Dichotomous Relationship of Intergenerational Caregiving within Elderly Care: Disruption/Disharmony and Connection/ Harmony Across the Generations

In Taiwan, caregiving for older person is an intergenerational responsibility. Modern Taiwanese society faces changing family structures and increased life expectancy of older people which prolongs caregiving responsibilities, however the family relationships of intergenerational caregiving experience are not fully known. This study explored how intergenerational caregiving reconstruct relationships between offspring caregivers and their frail older people to understand how health care services can better meet family needs. We conducted a genogram and eco-map to map individual support networks and relationships. We recruited 32 family members within 12 families across three generations to participate in an individual interview, including 11 frail older people, 3 spousal caregivers, 10 adult child caregivers and 8 grandchildren. The findings demonstrated that the intergenerational caregiving experience was a dichotomous relationship between disruption/disharmony and connection/harmony. For the caregiving experiences, individuals’ cultural values, beliefs, and family relationships should be considered in the context of shifting tradition, in Taiwan.
Improving the Usability of Real-Time Passive Stereo Sensors

There is an increasing industrial demand for robust real-time intelligent vision systems. High resolution stereo can play an important role but the high computational complexity for generating a depth map is the main concern. Hardware acceleration (using GPU or FPGA) can help satisfy real-time requirements. Symmetric Dynamic Programming Stereo (SDPS) is the highest throughput algorithm available on hardware (both in GPU and FPGA). However, the depth maps are generally noisy which reduces its usability. Therefore, the target here is to design and propose fast post-processing algorithms for the data generated by SDPS hardware which will improve its usability and will assist high level vision tasks. This thesis makes three main contributions. The first one is the fast depth contour generation algorithm. Depth contours represent object shapes which is the key feature for object modelling, detection, pose estimation and recognition. The second contribution is the Points-of-Interest detection algorithm; it is fast and robust to depth noise due to its use of left and right image pair. Both contour generation and Points-of-Interest detection take one pass which reduces the search space and then uses the reduced search space for subsequent processing. The third contribution are the two depth contour refinement algorithms. To improve depth contours, conventionally depth maps are refined before generating contours which can remove some fine details present in depth map. Two novel contour refinement algorithms are presented in this thesis which improve depth contours and reduce the number of streaks in the contour while preserving fine detail.
Improved multi-mode interferometers (MMIs) on silicon-on-insulator with the optimized return loss and isolation

In many integrated photonic circuits on silicon-on-insulator (SOI), e.g. integrated laser Doppler vibrometers, the return loss and isolation of multi-mode interferometers (MMIs) should be optimized. Several improvements, such as tilting the end-walls and increasing the taper lengths of the input and output ports can be done for the optimization. The return losses and isolations of different improved MMIs are simulated and compared by using the finite-difference time-domain method. MMIs with better return loss and isolation are predicted by the simulation.
Concentration, Foreign Participation and Bank Performance: An Empirical Study of Asian Emerging Markets

There is an abundance of literature on the relationship between market structure and profitability. Market share and concentration are usually analytical tools serving as indicators of market structure. There have been many empirical studies based on the structure–conduct–performance (SCP) theory. However, the correlation between market structure and bank interest spread has rarely been discussed in depth. Therefore, this paper constructs financial industry firm-level panel data of Asian emerging market countries from 2001 to 2015 to further explore the impacts of foreign bank participation, financial market concentration and the level of competition on bank spreads. Apart from the differences in samples, the most significant difference from the previous literature is that this paper considers the best indicators of competitiveness, namely the H value of the Panzar–Rosse (P-R) model to measure the banking market and competitive conditions. This study provides a more complete and detailed analysis by adopting the system GMM approach to perform the estimation and avoid the problem of endogeneity. Regarding the overall sample, the participation of foreign banks has had a positive and significant impact on bank interest spread, suggesting that the participation of foreign banks is a major factor influencing bank interest spread in the general financial markets in Asian emerging market countries, and that more foreign banks in local financial markets can help improve bank performance.
Comparative analysis for performance measurements of software testing between mobile applications and web applications

Software testing has an important role in software engineering, and is fundamental to Software Quality Assurance (SQA). Besides the popularity of web applications, mobile applications have gained paralleled advancement despite increasing complexity. On one hand, this issue reflects the rising concerns for ensuring performance both of web and mobile applications. On the other hand, a comparative analysis of software testing issues between web and mobile applications has not been completed. Thus, this study aims to employ an effective testing approach that is able to adapt both of web and mobile application testing to detect possible failures. To achieve this, UML activity diagrams were developed from four case studies for web and mobile applications to describe the behaviour of those applications. Test cases were then generated by using the MBT technique from the developed UML activity diagrams. Performance measurements Hits per Second, Throughput and Memory Utilization for each case study were evaluated by execution of test cases that were generated by using HP LoadRunner 12.02 tool. Finally, the MSE of performance measurements was compared and analysed among the four case studies. The experimental results showed that the disparity between the mobile applications and web applications was obvious. Based on the comparison analysis for software testing of mobile applications versus web applications that was the web applications were lesser than mobile applications for software testing of four case studies in terms each of the Hits per Second, Throughput and Memory Utilization. Consequently, mobile applications need more attention in the testing process.
Women in Entrepreneurship in Nigeria-Policy Framework, Challenges and Remedies

This paper evaluates the policy framework, challenges and remedies of women entrepreneurship in Nigeria. The paper reviewed policies on women empowerment from different administrations and past government in Nigeria. Design/methodology/approach – This study obtained primary data through the use of open ended questionnaire as an instrument administered to 570 female entrepreneurs currently engaged in businesses in Lagos, Ogun and Oyo States within South-West, Nigeria. A descriptive statistical analysis that helped us to calculate the frequency distribution of the responses from our respondents was used to analyze the data. Findings – The study revealed that although women entrepreneurs are gaining recognition in entrepreneurial activities, they are however confronted with several challenges. Some of these challenges include inadequacy of funds for start up and expansion, lack of electricity /infrastructural facilities, unconducive business environment, customers dissatisfaction and complaints, high level of competition and lack of trust worthy personnel, The findings also revealed that Nigerian women entrepreneurs are particularly constrained by their weak financial base, lack of business knowledge, inability to prepare business plan, family pressure and other socio- cultural hindrances. Research limitations/implications–Content analysis was used to analyze the data. Multivariate logistic regression analysis could not be used to analyze the data since the data was obtained through open ended questionnaire and interview. Practical implications – The results of the study showed that women entrepreneurs in Nigeria are ready to encourage themselves to ensure that they are making satisfactory progress irrespective of the challenges they face in their business. Originality/value – The study made original empirical contribution to body of the knowledge by obtaining a first hand information on the challenges facing women entrepreneurs in Nigeria and the best ways to encourage other women to be serious with their business. Hence, the study among other things recommends that the government should endeavour to recognize the economic role of women entrepreneurs and give them special attention in terms of making resources and facilities available to them for their entrepreneurial activities.
Analysis of WiFi Communication (Data Interchange) for Mobile Robot in Industrial Environment

Wireless network used in office is much cheaper than industrial-type devices. Using of office-type WiFi communication in industrial environment for exchange data between mobile platform (AGV) and base station is the core of this paper. The scope of research is data limitation flow in function of distance between system nodes and usability of office-type (low cost) equipment for establishes stable communication on industrial environment. Paper describes two experiments in two types of production environment. First one was realized in condition where several disturbance sources were active (like metal forming machine-tools, constant energy welding machines, electric overhead crane, high power electric motors, electronic inverters etc. All this machines contaminate radio environment around them and make serious obstacles for WiFi data exchange. Second experiment was executed in assembling hall of automobile production plant in which radio contamination is significantly lower.
The effects of teaching strategies on primary school students’ reading outcomes and interest in reading

Teaching text comprehension in primary school aims to develop long-lasting skills. This study assessed the direct and indirect effects of teaching strategies on students’ reading and interest in reading in primary school. Two hundred and twenty Estonian primary school students and their 18 native language teachers participated in the study. Correlation analysis indicated that students who achieved better results in read- ing and who were interested in reading in grade 1 had better results in vocabulary, text comprehension and reading interest in grade 3. Moreover, students’ vocabular y acquisition and text comprehension in grades 1 and 3 were associated with the promotion of students’ reading interest by teachers in grade 3. A structural equation model revealed that the frequent use of teaching strategies by teachers in grade 1 had a small positive longitudinal effect on students’ reading outcomes and interest in reading in grade 3. Knowledge of the different effects of teaching strategies on students’ reading outcomes and interest in reading would optimally promote students’ text compr ehension.