Miracle-dz/UniFAR-FTUs huggingface dataset:
ajopred.com SOLIDIFIED REVERSE MICELLAR SOLUTION-BASED MUCOADHESIVE NANO-EMULGEL IMPROVES THE DISSOLUTION OF POORLY SOLUBLE IMIDAZOLE ANTIFUNGAL FRANKLIN CHIMAOBI KENECHUKWU*, MUMUNI AUDU MOMOH, GOD’SPOWER TOCHUKWU ISAAC, LILIAN CHINONSO NWEKWO, ANTHONY AMAECHI ATTAMA AND EMMANUEL CHINEDU IBEZIM

Surface-modification using solidified reverse micellar solutions (SRMS) is a promising technique for improving the biopharmaceutical properties of active pharmaceutical ingredients. Here, we report on the formulation and characterization of colloidal nano-enabled emulsion impregnated gel delivery system based on SRMS containing mineral fat (beeswax) and surface-modifier [Phospholipon ® 90H (P90H)] (3:7) phospholipid-modified beeswaxbased nano-emulgels for prolonged duration of action and improved oromucosal bioavailabiliy of miconazole nitrate (MN), a poorly water-soluble imidazole antifungal that is commonly associated with poor aqueous solubility and dissolution, low bioavailability and short half-life in the treatment of oropharyngeal candidiasis. Solid lipid nanoparticles (SLNs) prepared with P90H-modified beeswax-based lipid matrix (SRMS) by high-shear hot homogenization (melt-emulsification) had low polydispersity indices, with average particle size and encapsulation efficiency values in the range of 204.0 ± 2.9 to 263.0 ± 7.1 nm and 36.23 ± 2.01 to 58.87 ± 3.56%, respectively. SRMS-based nano-emulgels developed from the SLNs by dispersion in polycarbophil (a mucoadhesive polymer) were stable and had better prolonged drug release (T12h = 36.25 – 63.67 %) than marketed formulation (Daktarin® oral gel) which showed fast drug release (T6h = 100%) in simulated salivary fluid (pH=6.8). This study has shown that phospholipid-modified beeswax-based lipid nano-emulgels could be employed as better alternative delivery system than Daktarin® oral gel to improve oropharyngeal dissolution and delivery of MN.
Coupling interactive fire with atmospheric composition and climate in the UK Earth System Model (UKESM)

Fire constitutes a key process in the Earth system (ES) being driven by climate as well as affecting the climate by changing 10 atmospheric composition and impacting the terrestrial carbon cycle. However, studies on the effects of fires on atmospheric composition, radiative forcing and climate have been limited to date, as the current generation of ES models (ESMs) do not include fully coupled fires. The aim of this work is the development and evaluation of a fully coupled fire-composition-climate ES model. For this, the INteractive Fires and Emissions algoRithm for Natural envirOnments (INFERNO) fire model is coupled to the atmosphere-only configuration of the UK’s Earth System Model (UKESM1). This fire-atmosphere interaction through atmospheric chemistry and aerosols allows for fire 15 emissions to influence radiation, clouds, and generally weather, which can consequently influence the meteorological drivers of fire. Additionally, INFERNO is updated based on recent developments in the literature to improve the representation of human/economic factors in the anthropogenic ignition and suppression of fire. This work presents an assessment of the effects of interactive fire coupling on atmospheric composition and climate compared to the standard UKESM1 configuration that uses prescribed fire emissions. Results show a similar performance when using the fire-atmosphere coupling (the “online” version of the model) when compared to the offline UKESM1 20 that uses prescribed fire. The model can reproduce observed present day global fire emissions of carbon monoxide (CO) and aerosols, despite underestimating the global average burnt area. However, at a regional scale there is an overestimation of fire emissions over Africa due to the misrepresentation of the underlying vegetation types and an underestimation over Equatorial Asia due to a lack of representation of peat fires. Despite this, comparing model results with observations of CO column mixing ratio and aerosol optical depth show that the fire-atmosphere coupled configuration has a similar performance when compared to UKESM1. In fact, including the interactive biomass 25 burning emissions improves the interannual CO atmospheric column variability and consequently its seasonality over the main biomass burning regions – Africa and South America. Similarly, for aerosols, the AOD results broadly agree with MODIS and AERONET observations.
Nuisance Canada Goose Problems in the Eastern United States

Canada geese (Branta canadensis) have increased in numbers in North America during the past 50 years. This expansion has resulted in goose-inflicted damage to many grain and green forage crops in rural areas (Horn 1949, Bossenmaier and Marshall 1958, Hunt and Bell 1973, Sugden 1976, Clark and Jarvis 1978, Hunt 1984). Recently, an increasing number of complaints has come from suburban and urban areas where geese forage on lawns located in parks, beaches, golf courses, country clubs, and backyards (Hawkins 1970, Laycock 1982). Even low numbers of geese can damage the grass and litter areas with their defecations. High densities of feces reduce the esthetic value and recreational use of these areas (Fig. 1) and are often perceived as health hazards. Droppings from large flocks of geese can also contribute to the over-fertilization of small lakes and reservoirs. This study addresses the history, extent, and severity of nuisance goose problems through surveys of water companies in Connecticut and golf courses throughout the eastern United States.
Prometheus: omics portals for interkingdom comparative genomic analyses

Functional analyses of genes are crucial for unveiling biological responses, for genetic engineering, and for developing new medicines. However, functional analyses have largely been restricted to model organisms, representing a major hurdle for functional studies and industrial applications. To resolve this, comparative genome analyses can be used to provide clues to gene functions as well as their evolutionary history. To this end, we present Prometheus (http://prometheus.kobic.re.kr),web-based omics portal that contains more than 17,215 sequences from prokaryotic and eukaryotic genomes. This portal supports interkingdom comparative analyses via a domain architecture-based gene identification system, Gene Search, and users can easily and rapidly identify single or entire gene sets in specific pathways. Bioinformatics tools for further analyses are provided in Prometheus or through BioExpress, a cloud-based bioinformatics analysis platform. Prometheus suggests a new paradigm for comparative analyses with large amounts of genomic information.
A survey on diversity and distribution of crabs in inter tidal and sub tidal shore of the Sistan and Baloochestan Province (Oman sea)

This project was done for identifying and survey on distribution and diversity of true crabs in inter tidal and sub tidal zones of the Gulf of Oman (Sistan and Baluchistan province) during two year from 2009 to 2010. Specimens of inter tidal zones were carried out at 10 stations and 8 stations from sub tidal. The specimens were collected by hand and dip-net from inter tidal and by trawl net from sub tidal regions, preserved in 70% alcohol and carried to the laboratory. A total of 37 species belonged to 17 families from inter tidal and 23 species belonged to 9 families from sub tidal were identified. Of which 54 species were identified up to species level. 2 species from Matutidae, 1 species from Eriphiidae, Menippidae, Pseudoziidae, Plagusidae, Varunidae, Camptandriidae, Dromiidae and Dorippidae, 2 species from Oziidae, 3 species from Epialtidae, 2 species from Majidae, 4 species from Pilumnidae, 12 species from Portunidae, 6 species from Xanthidae, 2 species from Grapsidae, 3 species from Dotillidae, 3 species from Macrophthalmidae, 3 species from Ocypodidae, 3 species from Calappidae, 2 species from Parthenopidae and 1 species from Galenidae were identified. All specimens are deposited in the Zoological Museum, University of Tehran (ZUTC). The results of the present study revealed that family Portunidae with 6 species from inter tidal and 9 species from sub tidal regions have the highest species richness among the 22 families. Maximum similarity (Sorenson's Index) was obtained among the stations Breis, Lipar, Pozm and Gordim, and minimum was obtained among the stations Chazire-Kharchang with Pasabandar, Beris, Lipar, Daria-Bozorg, Pozm and Gordim in intertidal regions. In sub tidal regions maximum similarity (Sorenson's Index) was obtained among the stations Pasa bandar with Berisand minimum was obtained among the stations Govatr with Ramin and Gordim, Ramin with Pozm. Also maximum species richness was observed at Tiss in inter tidal and Chabahar in sub tidal stations, whereas minimum was obtained at Beris, Pozm, Gordim and Lipar in inter tidal and Govatr and Pozm in sub tidal stations. Family Ocypodidae in inter tidal and Portunidae in sub tidal regions have the highest distribution. In all of the species length and Breadth of carapace showed significant relation.
Determination of physicochemical and pharmacological screening of leaves and flowers part of Pyrus pashia

Medicinal plants are best remedies used as alternative tools for the prevention and treatment of many ailments. Rosaceae (the rose family) is a medium-sized family of flowering plants, including about 2830 species in 95 genera. Rosaceae includes herbs, shrubs and trees. Most species are deciduous, but some are evergreen. In this study, the physicochemical evaluation; ash values, namely total ash, water-soluble ash, and acid-insoluble ash, and extractive values; namely ethanol-soluble extractive and water-soluble extractive values, moisture content by using loss of drying method, total phenolic and total flavonoid contents in Pyrus pashialeaves and flowers were used for illustrate the quality as well as purity and also investigated the pharmacological effect; namely antioxidant effect by using DPPH free radical assay. The total ash, water-soluble ash, and acid‑insoluble ash in Pyrus pashia leaves was found to be 5%, 3.1%, and 1.9%, respectively. In other side in Pyrus pashia flowers the total ash, water-soluble ash, and acid‑insoluble ash in Pyrus pashia leaves was found to be 5.12%, 3.05%, and 2.07%, respectively. The water-soluble extractive value was higher than alcohol-soluble extractive value in this study, and it was found to be 4.53% in leaves and 4.65% in flowers. The moisture content of the crude drug of leaves and flowers was found below 6.33% and 8.20%, respectively. The total phenolic content in the leaves and flowers extracts was found 180 ± 7 mg and 70 ± 9 mg of Gallic acid equivalent weight/g of extract, respectively, and the concentration of flavonoids in leaves and flowers extract of Pyrus pashia was found 371 ± 12 and 130± 10 mg of Quercetin equivalent weight/g of extract, respectively. The percentage inhibition of scavenging activities of the Pyrus pashia leaves and flowers showed 51.60% and 43.69% DPPH inhibition at 50 µg/mL concentrations. Whereas ascorbic acid showed 66.25% DDPH inhibition at 50 µg/mL.
THE NONLOCAL MULTIPOINT PROBLEM WITH DIRICHLET-TYPE CONDITIONS FOR AN ORDINARY DIFFERENTIAL EQUATION OF EVEN ORDER WITH INVOLUTION

Ya. O. Baranetskij, P. I. Kalenyuk, M. I. Kopach, A. V. Solomko. The nonlocal multipoint problem with Dirichlet-type conditions for an ordinary differential equation of even order with involution, Mat. Stud. 54 (2020), 64–78. The spectral properties of the nonself-adjoint problem with multipoint perturbations of the Dirichlet conditions for differential operator of order 2n with involution are investigated. The system of eigenfunctions of a multipoint problem is constructed. Sufficient conditions have been established, under which this system is complete and, under some additional assumptions, forms the Riesz basis. The research is structured as follows. In section 2 we investigate the properties of the Sturm-type conditions and nonlocal problem with self-adjoint boundary conditions for the equation
Effect of xylanase, urea, Tween and Triton additives on bioethanol production of corn stover

Corn stover is a potential source of renewable biomass for conversion to bioethanol. Fed-batch semi-simultaneous saccharifcation and fermentation (S-SSF) of corn stover pretreated by liquid hot water (LHW) was investigated. The present study aimed to confirm the influence of xylanase, urea, Tween and Triton additives on bioethanol. Results show that the positive effect of xylanase, urea, Tween was observed. High ethanol concentration requires the addition of xylanase in the stage of saccharification. The optimal amount of xylanase was 0.2 g/g biomass and addition of Triton (Triton X-100) increases the effect of xylanase. Urea has a promotion effect on the whole fermentation process.When adding 0.1% urea in the fermentation stage,the best promoting rate is 24.2%. In the longitudinal comparison of the Tween series, under the same experimental conditions, the promoting effect of Tween series: Tween 40 > Tween 80 > Tween 20 > Tween 60.
New species of flesh fly (Diptera: Sarcophagidae) Sarcophaga (Liosarcophaga) Geetai in India

Sarcophaga (Liosarcophaga) geetai, flesh fly is a new species of genus Sarcophaga reported from Aurangabad City, Maharashtra state of India. Sarcophaga geetai was found in the campus of Dr. Babasaheb Ambedkar Marathwada University, Aurangabad during the Ph.D. research work, on different species of forensic importance. The fly is of medical importance, causing myiasis and useful in determination of post mortem interval.
Sexual obsession compulsive disorder: 11 case studies

Obsessive-Compulsive Disorder (OCD) is a long-lasting disorder characterized by cyclic feelings and compulsive behaviors which lead to momentary relief. One of the recognized feature in obsessive-compulsive disorder is sexual obsessions. Compulsive sexual behavior has not yet received wide consideration from researchers and clinicians. Till date, there have been dearth of formal studies of sexual behavior in OCD. In spite of the scarcity of research, many patients with sexual obsession do present for the treatment andmental health professionals in any setting are likely to come across patients with this disorder. The present study aims to af irm that sexual obsessions are prevalent clinical features in OCD that arise sex based symptoms. For that purpose, the data was composed from 11 patients, in which the symptoms were existent for more than 1 year. The data was collected in the form of history taking Structured Clinical Interview, that has been a part of case studymethod. Itwas found that the patients display an obsession with the sexual acts and feel discomfort if unable to control their urges which later affect their personal and social functioning. So this paper will focus and summarize sexual behavior in OCD with the help of case studies.
Field Evaluation of Spinetoram 12 SC against Leaf Damage due to Spodoptera litura Fabricius on Onion

India is the second largest producer of onion, Allium cepa L. in the world after China. It is cultivated in an area of 10.52 lakh hectares in india with an annual production of about 168.13 lakh tonnes. In Tamil Nadu it occupies in area of 0.37 lakh hectares with an annual production of 4.30 lakh tonnes during 201213 (1). Among several factors that limit onion cultivation, insect pests stand foremost in reducing the yield in India and each year about 10 to 25 per cent of the world’s total production is lost due to pests attack (2). Young cutworm larvae, Spodoptera litura (F.) feed on tender foliage and grown up larva cut the stem at collar region. The leaf feeder, S. litura is a potential polyphagous pest which attack many other crops such as cotton, groundnut, rice, tomato, tobacco, citrus, cocoa, potato, rubber, castor, millets, sorghum, maize etc., in India and cause extensive economic damage (3). Synthetic insecticides provide dramatic effect initially, and hence chemical control methods are still in use among farmers. Earlier, conventional insecticides like endosulfan (4) and (5), malathion and hostathion (6), (7) chlorpyriphos, azadirachtin 1%, phosalone and quinalphos (8), synthetic pyrethroids and endosulfan alternatively with NSKE 4% (9), and fenvalerate, methomyl, azinphosmethyl, carbaryl and pyrethrin/rotenone (10) were reported in management of pests on onion. International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 6 Number 11 (2017) pp. 2824-2829 Journal homepage: http://www.ijcmas. com
Navigating the Human Epigenome through Random Forests

With the recent identification of over 100 histone modifications in mammalian cell-types, there is an urgent need to discover the minimal set of modifications that can completely characterize a genomic element. Of particular interest are transcriptional enhancers that play critical roles in cell-type specific gene expression but are difficult to characterize because they often act in a distal manner to the gene they regulate. We developed a Random-Forest based algorithm, RFECS (Random Forest based Enhancer identification from Chromatin State) for genome- wide prediction of enhancers which allowed us to identify the most informative and robust set of three chromatin marks for enhancer prediction. In addition, RFECS was seen to have improved accuracy of prediction over previous methods. Applying this method to other genomic elements, we identified the minimal set of histone modifications required for prediction of promoters and gene bodies. Further, we elucidated the distinctive localization of histone lysine acetylations at enhancers, promoters and gene bodies, and obtained novel insights into the association of chromatin modification patterns with splicing. Using our algorithm, we predicted enhancers and promoters in 26 human primary tissues and 6 cell-lines, including 5 early developmental lineages. This lead us to the discovery of a novel class of cis-regulatory elements that can behave as enhancers in one cell-type and promoters in another. Further, we were able to associate the evolutionary conservation of regulatory sequences with properties such as tissue-specificity. RFECS is a powerful algorithm with two-fold advantage. First, we can identify the most informative set of modifications characterizing or distinguishing particular genomic elements, thus enabling an insight into the biological mechanism of function at these regions. Second, we can make accurate predictions of enhancers and promoters in a genome-wide fashion, enabling the comparison of regulatory mechanisms across various human tissues or cellular conditions. Variations of histone modification patterns at the predicted tissue-specific cis-regulatory elements may substantially influence gene expression, which could potentially explain the distinct phenotypes of genotypically identical tissues
Method for rearing predatory mites

The present invention relates to the field of biological control. Specifically, it relates to the use of predator mites as biological control agents for reducing damage to crops by insect pests. In particular, it relates to a new method for rearing predator mites, and a method for controlling pests in a crop using predator mites reared using said method.
Orienting behaviours and attentional processes in the mouse and macaque : neuroanatomy, electrophysiology and optogenetics

The neuronal basis of orienting and attentional behaviours has been widely researched in higher animals such as non-human primates (NHPs). However the organisation of these behaviours and processes in rodent models has been less well characterised. This thesis is motivated to delineate the key neuroanatomical pathways and neuronal mechanisms that account for orienting behaviours in the mouse model and compare them, in part, to those seen in the macaque. A better understanding of the processes and networks involved with attention and orienting is necessary in order to relate findings in the mouse model to those seen in humans and NHPs. Further to this, the availability of highly targeted manipulations in the mouse, such as optogenetics, requires a more detailed picture of the neurophysiology underpinning those behaviours to effectively interpret findings and design experiments to exploit these techniques and animal models for maximum benefit. In this thesis, study one focuses on the neuroanatomical pathways that terminate in subregions of the midbrain superior colliculus (SC) in the mouse (mus musculus) using iontophoretic injection of the retrograde tracer fluorogold. This region has been implicated in various forms of orienting behaviours in both macaques and mice (Albano et al., 1982, Dean et al., 1988b, Felsen and Mainen, 2008). Furthermore study one examines the prefrontal connectivity that links to the SC subsections and which may govern approach and avoidance behaviours (motor cortex area 2 (M2) and cingulate area (Cg)) in the mouse via pressure injection of the anterograde tracer biotinylated dextran amine into these regions. It was found that the medial and lateral SC receive differential prefrontal input from the Cg and M2 respectively. And that these areas project to brain networks related to avoidance or approach. This section furthers our understanding of the partially segregated networks which exist in the prefrontal cortex and midbrain of the mouse, which are important in mediation of different orienting behaviours Study two focuses on the effects of one type of orienting, namely bottom-up attention (BU) in visual areas. This exogenous (automatic) form of visual attention has been studied extensively in human psychophysics (Posner, 1980, Nakayama and Mackeben, 1989) and the areas involved in the human brain have been delineated using brain imaging (Corbetta and Shulman, 2002, Liu et al., 2005). To understand the neurophysiology involved, some electrophysiological invasive studies have been performed in the macaque monkeys,
Interference hypothesis for recombination suppression in chromosomal inversion heterozygotes: A formal genetics analysis in Drosophila melanogaster

Suppressed recombination in chromosomal inversion heterozygotes is a well-known but poorly understood phenomenon. Recombination suppression is the result of at least four different regional effects of inversion heterozygosity; surprisingly, this includes areas outside inversions where there are no barriers to normal pairing, synapsis, double strand break formation, or recovery of crossover products. The interference hypothesis of recombination suppression proposes heterozygous inversion breakpoints possess chiasma-like properties such that recombination suppression extends from breakpoints in a process analogous to crossover interference. This hypothesis is qualitatively consistent with chromosome-wide patterns of recombination suppression, unifying the various regional effects under a single mechanism. The present study generates quantitative predictions for this hypothesis using a probabilistic model of crossover interference as a stationary renewal point process with gamma-distributed interarrival distances. These predictions were tested with formal genetic data (>40,000 meioses) on crossing-over in intervals external and adjacent to four cosmopolitan inversions of Drosophila melanogaster. The decay of recombination suppression differs for each of the four cosmopolitan inversions, with a strong dependence on proximity to the centromere. Counterintuitively, greater than expected recombination was observed in centromeric regions for the most proximally placed inversions. Structural features of chromosomes are discussed as potentially confounding variables in modelling recombination suppression. The true form of the decay function is not currently known and will require high-resolution mapping of rare crossover events in regions immediately adjacent to inversion breakpoints. A simple extension of the present experimental system can be conducted as a genetic screen for those rare crossover events.