Miracle-dz/UniFAR-FTUs huggingface dataset:
Title: U-shaped association between plasma sphingosine-1-phosphate levels and mortality in patients with chronic systolic heart failure: A prospective cohort study.

: Background: The endogenous lipid molecule sphingosine-1-phosphate (S1P) has received attention in the cardiovascular field due to its significant cardioprotective effects, as revealed in animal studies. The purpose of our study was to identify the distribution characteristics of S1P in systolic heart failure patients and the prognostic value of S1P for long-term prognosis. Methods: We recruited 210 chronic systolic heart failure patients from June 2014 to December 2015. Meanwhile 54 healthy people in the same area were selected as controls. Plasma S1P was measured by liquid chromatography-tandem mass spectrometry. Patients were grouped according to the baseline S1P level quartiles, and restricted cubic spline plots described the association between S1P and all cause death. Cox proportional hazard analysis was used to determine the relationship between category of S1P and all-cause death. Results: Compared with the control group, the plasma S1P in chronic heart failure patients demonstrated a higher mean level (1.269 μmol/L vs 1.122 μmol/L, P =0.006) and a larger standard deviation (0.441 vs 0.316, P =0.022). After a follow-up period of 31.7 ± 10.3 months, the second quartile (0.967-1.192μml/L) with largely normal S1P levels had the lowest all-cause mortality and either an increase (HR=3.87, 95%CI 1.504-9.960, P =0.005) or a decrease (HR=3.271, 95%CI 1.277-8.381, P =0.014) predicted a worse prognosis. Being grouped into the quartile4 group after correction of other variables with prognostic values for all-cause mortality (adjusted HR=3.685 [1.391-9.763], p=0.009) still predicted a worse prognosis. The survival curves showed that S1P levels in the quartile1 and quartile4 groups significantly reduced the patient survival rate. Conclusions : Plasma S1P levels in systolic heart failure patients are related to the long-term all-cause mortality with a U-shaped correlation.
Polyethylene glycols (PEGs) (average molar mass 200–600). MAK Value Documentation, supplement – Translation of the German version from 2019

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated polyethylene glycols (PEGs) (average molar mass 200–600) [25322-68‑3] considering all toxicological endpoints. In 13-week studies in rats, the NOAEC for aerosols of PEG 200 and PEG 400 was the highest concentration tested of 1000 mg/m 3 . Taking into account the increased respiratory volume at the workplace (see List of MAK of a 3% aqueous formulation of a solid soap containing PEG 300 was applied occlusively to the upper arm of 200 volunteers 10 times for 2 to 3 days for a total exposure period of three and a half weeks. After an interval of 2 weeks, the challenge treatment was carried out with the occlusive application of a 1% formulation for 3 days. One volunteer exhibited a marked, scattered reaction that was reproducible to a similar degree in 3 subsequent challenge treatments carried out at intervals of 2 weeks. Tests were then performed with the individual constituents of the soap, which resulted in a strong reaction to 3% PEG 300 in petrolatum. Additional tests carried out with 3% and 1% PEG 600, PEG 1000, PEG 4000 and PEG 6000 (in petrolatum),
EPIDEMIOLOGICAL ASPECT OF BOVINE VIRAL DIARRHEA VIRUS- II INFECTION IN DAIRY CATTLE

The purpose of this study was to characterize the clinical and virologic features of the mucosal and thrombocytopenic BVDV infection in infected dairy cattle. Strategy of examination included clinical examination of diseased animals, serum samples (n=31) represented all diseased cattle, milk samples (n=8) represented clinically diseased cattle and vaginal swabs (n=8) from the hemorrhagic diseased and aborted cattle were tested. An international reference strain (NADL: National Animal Disease Laboratory) and local cytopathic BVDV genotype-II strain (Behera-CP 58/99) were used as positive controls. The virus was isolated from the 8 vaginal swabs and 5 out of the 8 milk samples. All the isolates were ncp that no CPEs were noticed over the 3 passages. By specific BVDV genotype -II monoclonal antibodies (MAbs) against gp53, the viral antigen was identified using Fluorescence isothiocyanate (FITC)-conjugated anti-bovine IgG (specific intra cytoplasmic fluoresce granules) and horseradish peroxidase (HRP)-conjugated anti-bovine IgG (specific intra cytoplasmic brown granules) were detected. By enzyme linked immunosorbant assay (ELISA) technique, all serum samples were positive against the BVDV that had neutralizing antibodies titer ranges from ≥ 1/128 to ≥ 1/512. In conclusion, BVDV type -II do exist in cattle population and the understanding the molecular epidemiology is fundamental. Improved diagnostic and control strategies are essential to reduce losses inflected by BVDVs infection.
Local instability of symmetrical rectangular tubes under axial compression

A chart is presented for the coefficient in the formula for the critical compressive stress at which cross sectional distortion begins in a thin-wall tube of rectangular section symmetrical about its two principal axes. The energy method of Timoshenko was used in the theoretical calculations required for the construction of the chart. The deflection equation used in this method was selected to give good accuracy. The exact values given by solution of the differential equation were calculated for a number of cases and it was found that the energy solution was correct to within a fraction of 1 percent. The calculation of the critical compressive stress at stresses above the elastic range is also discussed. In order to demonstrate the use of the formulas and the chart in engineering calculations, several illustrative problems are included.
Consiglio Nazionale delle Ricerche Willage: A Two-Tiered Peer-to-Peer Resource Sharing Platform for Wireless Mesh Community Networks

The success of experiences such as Seattle and Houston Wireless has attracted the attention on the so called wireless mesh community networks . These are wireless multihop networks spontaneously deployed by users willing to share communication resources. Due to the community spirit characterizing such networks, it is likely that users will be willing to share other resources besides communication resources, such as data, images, music, movies, disk quotas for distributed backup, and so on. In other words, it is expected that peer-to-peer applications will be deployed in such type of networks. In this paper we propose Willage , a platform for resource localization in wireless mesh community networks with mobile users. The platform is based on a two-tiered architecture: resources are made available at the lower tier, which is composed of mobile terminals, whereas information on their localization is managed at the upper layer, which is composed of wireless mesh routers. We also introduce Georoy , an algo-rithm for the eﬃcient retrieval of the information on resource localization based on the Viceroy algorithm. Simulation results show that Willage achieves its goal of enabling eﬃcient and scalable peer-to-peer resource sharing in wireless mesh community networks.
Seismic Moment Tensor Solutions from GeoNet Data to Provide a Moment Magnitude Scale for New Zealand

The aim of this project is to enable accurate earthquake magnitudes (moment magnitude, MW) to be calculated routinely and in near real-time for New Zealand earthquakes. This would be done by inversion of waveform data to obtain seismic moment tensors. Seismic moment tensors also provide information on fault-type. I use a well-established seismic moment tensor inversion method, the Time-Domain [seismic] Moment Tensor Inversion algorithm (TDMT_INVC) and apply it to GeoNet broadband waveform data to generate moment tensor solutions for New Zealand earthquakes. Some modifications to this software were made. A velocity model can now be automatically used to calculate Green's functions without having a pseudolayer boundary at the source depth. Green's functions can be calculated for multiple depths in a single step, and data are detrended and a suitable data window is selected. The seismic moment tensor solution that has either the maximum variance reduction or the maximum double-couple component is automatically selected for each depth. Seismic moment tensors were calculated for 24 New Zealand earthquakes from 2000 to 2005. The Global CMT project has calculated CMT solutions for 22 of these, and the Global CMT project solutions are compared to the solutions obtained in this project to test the accuracy of the solutions obtained using the TDMT_INVC code. The moment magnitude values are close to the Global CMT values for all earthquakes. The focal mechanisms could only be determined for a few of the earthquakes studied. The value of the moment magnitude appears to be less sensitive to the velocity model and earthquake location (epicentre and depth) than the focal mechanism. Distinguishing legitimate seismic signal from background seismic noise is likely to be the biggest problem in routine inversions.
Intraperitoneal delivery of human natural killer cells for treatment of cancer in a mouse xenograft model.

Background aims— There is an urgent need for novel therapeutic strategies for relapsed ovarian cancer. Dramatic clinical antitumor effects have been observed with interleukin (IL)-2 activated natural killer (NK) cells; however, intravenous delivery of NK cells in patients with ovarian cancer has not been successful in ameliorating disease. We investigated in vivo engraftment of intraperitoneally (IP) delivered NK cells in an ovarian cancer xenograft model to determine if delivery mode can affect tumor cell killing and circumvent lack of NK cell expansion. Methods— An ovarian cancer xenograft mouse model was established to evaluate efficacy of IP-delivered NK cells. Tumor burden was monitored by bioluminescent imaging of luciferase-expressing ovarian cancer cells. NK cell persistence, tumor burden and NK cell trafficking were evaluated. Transplanted NK cells were evaluated by flow cytometry and cytotoxicity assays. Results— IP delivery of human NK cells plus cytokines led to high levels of circulating NK and was effective in clearing intraperitoneal ovarian cancer burden in xenografted mice. NK cells remained within the peritoneal cavity 54 days after injection and had markers of maturation. Additionally, surviving NK cells were able to kill ovarian cancer cells at with 51 Chromium for 1 h at 37°C, washed three times and co-cultured with NK cells at indicated effector to target (E:T) ratios. Total lysis (test release) was achieved with the use of 5% Triton-X 100. After a period of 4 h, cells were harvested and analyzed. Specific 51 Chromium lysis was calculated by means of the equation
Body Aura — A New Approach Towards Ambient Intelligence

—The 21 st century will be characterized by a number of technical revolutions, which will not leave the ways in which humans interact unchanged. New forms of interactions will change our society in unforeseeable ways. On the other hand, pressing problems such as environmental protection, energy shortages, the spread of pandemic diseases, global crises, etc., demand novel approaches to collect and to correlate more precisely demographic data. To analyze this challenge and to investigate possible technological scenarios, this paper introduces the concept of a Body Aura , a digital extension of the body functions of a person or a group of persons to the environment.
Effect of Interferon- (cid:1) on Prostaglandin Biosynthesis, Transport, and Signaling at the Time of Maternal Recognition of Pregnancy in Cattle: Evidence of Polycrine Actions of Prostaglandin E 2

Recognition and establishment of pregnancy involve several molecular and cellular interactions among the conceptus, uterus, and corpus luteum (CL). In ruminants, interferon- (cid:1) (IFN (cid:1) ) of embryonic origin is recognized as the pregnancy recognition signal. Endometrial prostaglandin F 2 (cid:2) (PGF 2 (cid:2) ) is the luteolysin, whereas PGE 2 is considered a luteoprotective or luteotrophic mediator at the time of establishment of preg- nancy. The interplay between IFN (cid:1) and endometrial PGs production, transport, and signaling at the time of maternal rec- ognition of pregnancy (MRP) is not well understood. We have studied the expression of enzymes involved in metabolism of PGE 2 and PGF 2 (cid:2) , cyclooxygenase-1 (COX-1) and COX-2, PG synthases (PGES and PGFS), PG 15-dehydrogenase, and PG transporter as well as PGE 2 (EP2 and EP3) and PGF 2 (cid:2) recep- tors. IFN (cid:1) influences cell-specific expression of COX-2, PGFS, EP2, and EP3 in endometrium, myometrium, and CL in a spatio-temporal and tissue-specific manner, whereas it does not alter COX-1, PGES, PG 15-dehydrogenase, PG transporter, or PGF 2 (cid:2) receptor expression in any of these tissues. In endometrium, IFN (cid:1) decreases PGFS in epithelial cells and in- creases EP2 in stroma. In myometrium, IFN (cid:1) decreases PGFS and increases EP2 in smooth muscle cells. In CL, IFN (cid:1) in- creases PGES and decreases EP3. Together, our results show that IFN (cid:1) directly or indirectly increases PGE 2 biosynthesis and EP2-associated signaling in endometrium, myometrium, and CL during MRP. Thus, PGE 2 may play pivotal roles in endometrial receptivity, myometrial quiescence, and luteal maintenance, indicating polycrine (endocrine, exocrine, paracrine, and autocrine) actions of PGE 2 at the time of MRP. Therefore, the establishment of pregnancy may depend not onlyoninhibitionofendometrialPGF 2 (cid:2) ,butalsoonincreased PGE 2 production in cattle. ( Endocrinology 145: 5280–5293, 2004)
No-fault patient compensation for medical malpractice in Thailand: option or not?

Thailand and its ASEAN partners, like many countries, employ strategies to provide quality care. They also face challenges from unsafe and negligent care, which may create transactions costs for their healthcare (e.g. defensive medicine) and legal systems (e.g. claims, litigation, and payouts). Like many countries, Thailand adopts traditional and / or nontraditional (e.g. no-fault patient compensation system (NFPCS)) tort reforms to limit these costs. Attempts to enact NFPCS usually fail. Thailand failed to enact a NFPCS through its Law on Health Service A ﬀ ected Person Protection in 2007. To learn why NFPCS adoption e ﬀ orts fail, the authors conducted a modiﬁed scoping review of the literature employing electronic, English keyword-based Arksey and O’Malley and PICOTS search of public (Google, Google Scholar, EBSCO, and Medline) and private (Lexis) databases. Review yielded 105 reviewable NFPCS publications, which revealed 9 countries and 2 U.S states (Florida and Virginia) adopted general (N = 6) or limited (N = 5) NFPCS schemes. After 2000, 5 countries (Canada, England, Ireland, Scotland, and Thailand) and 6 US States (Georgia, Maine, Maryland, Montana, New Hampshire, and Tennessee) attempted and failed. Conditions (e.g. reasons or factors) favoring or disfavoring adoption) included concerns for: (1) fairness of compensation amounts versus judicial awards, (2) excessive NFPCS costs, (3) system-based tort reform preferences, and (4) professional (medical and legal) association resistances. In conclusion, a minority of countries and US states currently maintain successful NFPCSs. NFPCS adoption remains a challenge worldwide, especially if the medical and legal professions oppose adoption.
A study of areas of low radio-thermal emissivity on Venus

Observations performed by the Magellan radiometer experiment have confirmed previous findings that a few regions on Venus, primarily at higher elevations, possess unexpectedly low values of radiothermal emissivity, occasionally reaching as low as 0.3. Values of emissivity below 0.7 occur over about 1.5% of the surface, and are associated with several types of feature, including highlands, volcanoes, tectonically uplifted terrain, and impact craters. There is a strong correlation of low emissivity and high elevation, but rather than decreasing gradually with elevation, the emissivity drops rapidly in a small altitude range above a certain "critical radius. " The altitude at which the change in emissive properties occurs varies from feature to feature; on average, it lies at a planetary radius of about 6054 km. Notable exceptions to the association of low emissivity and high elevation exist; for example, Lakshmi Planum, Maat Mons, and the summits of many volcanoes display high emissivities at high elevations, while in some impact craters and plains areas we find low emissivities at low elevations. Two possible explanations for low emissivities have been advanced: (1) emission from a highly reflective single interface between the atmosphere and a surface material having a bulk dielectric constant of order 80 ("high-dielectric" model); and (2) emission from the surface of a low-loss soil having a more usual permittivity (of order 2) which contains subsurface scatterers composed of ordinary rock materials ("volume scattering" model). Theoretical results and Monte Carlo simulations are used to show that the previously proposed volume scattering model cannot account for the observed emissivities; however, scattering from a material with very low loss (loss factor of order 10' or less) containing subsurface voids could produce the observed results. Consideration of the two models in light of the Magellan observations leads us to believe that the low emissivities on Venus result from the creation of a high-dielectric material by surface-atmosphere interaction, probably a loaded dielectric containing a conductive mineral. Thesis Supervisor: Gordon H. Pettengill Title: Professor of Planetary Physics
Introductory Chapter: Ferroelectrics Material and Their Applications Introductory Chapter: Ferroelectrics Material and T heir Applications

Ferroelectricity is a symptom of inevitable electrical polarisation changes in materials without external electric field interference. Ferroelectricity is a phenomenon exhibited by crystals with a spontaneous polarisation and hysteresis effects associated with dielectric changes when an electric field is given. Our fascination with ferroelectricity is thanks to a beautiful article by Itskovsky, in which he explains about kinetics of a ferroelectric phase transition in thin ferroelectric layer (film) [1]. We have been researching about ferroelectrics materials since 2001 [2, 3].
Facilitators and Barriers to Breastfeeding Practices of Mothers in a Selected Urban Community in Malaysia

This study was designed to explore the facilitators and barriers of breastfeeding practices among mothers in a selected urban population in Malaysia. This study reports the qualitative findings from a larger study that was conducted in two health clinics in Selangor, Malaysia. Ten mothers were recruited and an in-depth interview using grounded theory approach was used to obtain information. Interviews were transcribed and was manually arranged into codes and themes using thematic analysis. Facilitators to breastfeeding in this population were maternal factors (knowledge of breastfeeding, intention to breastfeed, perceived benefits of breastfeeding), social support and health care provider. Barriers to breastfeeding were insufficiency of breastmilk, employment and stigma of public breastfeeding. The findings of this study suggest that intervention to improve breastfeeding uptake should aim on increasing knowledge of mothers on coping with issues related to breastfeeding difficulties such as how to increase or sustain milk production and increasing awareness of employers and public on supporting breastfeeding mothers.
Factorization without Factorization: Complete Recipe

The Tomasi-Kanade factorization for reconstructing the 3-D shape of the feature points tracked through a video stream is widely regarded as based on factorization of a matrix by SVD (singular value decomposition). This paper points out that the core principle is the affine camera approximation to the imaging geometry and that SVD is merely one means of numerical computation. We first describe the geometric structure of the problem and then give a complete programming scheme for 3-D reconstruction.
Detecting and Categorization of Click Baits

—Clickbaiting is a growing phenomena on the internet, and it is defined as a method of exploiting cognitive biases to attract online viewership, that is, to attract clicks.The articles behind clickbaits are usually uninformative, and besides contributing to an overall decline in journalistic integrity,clickbaits spread misinformation, often by making shocking implications, only to backtrack on those claims in the article.Examples of clickbait titles are:10 ways the expat life Is like a continual espresso buzz 5 incredible Italian dishes you havent tried before What India microloan meltdown taught one entrepreneur Clickbaiting can come in many forms, like advertisements, videos, and such, but the matter is that websites are highly incentive to publish clickbait articles because they’re cheap to produce and can generate revenue. The main motivation in trying to spot clickbait is to seperate out potential sources of misinformation on the net. With the event of online advertisements, clickbait spread wider and wider. Clickbait dissatisfies users because the article content does not match their expectation. A convolutional neural network is beneficial for clickbait detection, since it utilizes pre-trained Word2Vec to know the headlines semantically, and employs different kernels to search out various characteristics of the headlines. However,different types of articles tend to use alternative ways to draw users attention, and a pre-trained Word2Vec model cannot distinguish these alternative ways. We propose a completely unique approach considering all information found during a social media post. We train a bidirectional Long ShortTerm Memory(LSTM) with an attention mechanism to learn the extent to which a word contributes to the posts clickbait score in a differential manner.
Glucocorticoid Hormone Regulates the Circadian Coordination of (cid:1) -Opioid Receptor Expression in Mouse Brainstem □ S

The 24-h variation in glucocorticoid secretion from the adrenal cortex is observed not only in nocturnally active rodents but also in diurnally active humans. Although the cyclic change in circulating glucocorticoid levels is thought to influence the efficacy and/or toxicity of many drugs, the mechanism underlying the influence remains poorly understood. In this study, we demonstrate that the 24-h variation in circulating glucocorticoid levels modulates the analgesic effect of morphine by regulating the expression of the (cid:1) -opioid receptor. Significant time-de-pendent variations in the mRNA levels of the (cid:1) -opioid receptor and its binding capacity were observed in mouse brainstem. The analgesic effect of morphine was enhanced by administering the drug when (cid:1) -opioid receptor levels were increased. However, corticotrophin-releasing hormone (CRH)-deficient mice, disrupting the 24-h rhythm of glucocorticoid secretion, showed no significant time-dependent variation in the expres- sion of the (cid:1) -opioid receptor. As a consequence, there was no significant dosing time-dependent difference in the analgesic effect of morphine in CRH-deficient mice. A single administration of corticosterone significantly induced the expression of the (cid:1) -opioid receptor in the CRH-deficient mouse brainstem and also enhanced the analgesic effect of morphine. These findings suggest a mechanism underlying the time-dependent variation in (cid:1) -opioid receptor function and provide clues to select the most appropriate time of day for administration of morphine.