Miracle-dz/UniFAR-FTUs huggingface dataset:
Physical effort of middle-aged women in a university hospital – Field tests in comparison to standardized cardiopulmonary exercise testing (CPET)

Abstract Physical effort of workload of female employees in the healthcare system is perceived to rise. Research focused mainly on physical activity levels of registered nurses (RN). Therefore, we investigated physical strain during daily routine of other hospital workers next to RN. O2uptake, heart rate, breathing frequency and ventilation were measured in 33 female medical (associate) professionals (MAP) and Cleaners&Helpers (Cl&H) using Oxycon Mobile. Physical work load was compared to standardized CPET. Wilcoxon-test and ANOVA were calculated using SPSS 20.0. Cl&H performed heavy-lifting and had the lowest power during CPET. The O2-uptake for heavy-lifting as strong effort, differed significantly from office work (p < 0.001) and bedside-patient-care (p = 0.001). Compared with metabolic equivalent (MET) cleaning, heavy-lifting, and office work are underestimated. Bedside-patient-care, walking, pushing performed by MAP are overestimated. While Cl&H had the lowest maximal power in CPET, their work required the highest O2-uptake. The tasks are underestimated in the MET-tables.
Mutations at two new Arabidopsis ABA response loci are similar to the abi3 mutations

Summary Two new Arabidopsis loci involved in ABA response, ABA-insensitive (ABI)4 and ABI5, have been identified by mutation. The abi4 and abi5 mutants were characterized in terms of ABA sensitivity of seed germination, dormancy, seed-specific gene expression and stomatal regulation. Their phenotypes are similar to mutations in ABI3, which is thought to encode a seed-specific transcriptional activator. Analysis of double mutants combining abi4 and abi5 mutations with abi1, abi2 or abi3 mutations also suggests that ABI4 and ABI5 act in the same transduction pathway as ABI3.
Altrenogest affects the development and endocrine milieu of ovarian follicles in prepubertal and mature gilts†

Abstract Altrenogest with gonadotropins is commonly used to synchronize the estrous cycle, but it can also lead to follicular cyst formation, especially in prepubertal gilts. Here, we aimed to investigate how maturity and altrenogest treatment affect the development, endocrine milieu, and molecular control of ovarian follicles. Crossbred prepubertal and mature gilts were challenged or not (control) with altrenogest, and ovaries were collected in the morning on the first day of behavioral estrus. In prepubertal gilts, altrenogest decreased the percentage of primordial and atretic small follicles, but increased large antral follicles when compared with controls. In mature gilts, altrenogest reduced the percentage of primary follicles and elevated the total number of antral follicles. Maturity affected the estradiol level in the follicular fluid of preovulatory follicles, luteinizing hormone (LH)-stimulated cyclic adenosine monophosphate (cAMP) generation, and LH receptor messenger RNA (mRNA) expression in granulosa. Moreover, cytochrome P45017A1 (CYP17A1) mRNA levels in the theca layer were affected and correlated with follicular androstendione and estradiol concentration. Altrenogest negatively affected follicular fluid progesterone concentration and decreased levels of prostaglandin (PG) E2 in prepubertal gilts and PGF2alpha metabolite in mature gilts. LH-stimulated cAMP release in granulosa cells of mature gilts as well as human chorionic gonadotropin- and forskolin-induced cAMP were also affected. In addition, altrenogest downregulated CYP17A1 mRNA in the prepubertal theca layer and PGF2alpha synthase expression in the granulosa and theca layer of mature gilts. To the best of our knowledge, this is the first study to report multiple effects of maturity and altrenogest on the endocrine milieu and molecular regulations governing ovarian follicle development in gilts. Summary Sentence Sexual maturity and altrenogest change endocrine milieu and molecular regulations governing folliculogenesis in gilts.
Systolic time intervals assessed by 2‐D echocardiography and spectral Doppler in the horse

In the present study, the ‘acoustic windows’ for the measurement of the left ventricular systolic time intervals is studied by means of 2-D echocardiography and cardiac Doppler ultrasonography, and the normal values in the horse (n = 112) are determined. The left ventricular isovolumetric contraction time, the pre-ejection period (PEP), as well as the left ventricular ejection time (LVET) have been measured, and the values of the left ventricular total electromechanical systole (LVTES) and the PEP-to-LVET ratio have been calculated. It has been established that the most suitable window for the measurement of the aforementioned indices in 2-D echocardiography is the right parasternal window in a view in short axis at the level of the cardiac base to measure the aortogram. In Doppler ultrasonography, the preferred window is the left parasternal using the five chambers apical view. The following values have been acquired: PEP = 0.071 ± 0.01 s; LVET = 0.532 ± 0.097 s; LVTES = 0.6 ± 0.1 s and PEP-to-LVET = 0.138 ± 0.025 measured by 2-D echocardiography and PEP = 0.068 ± 0.009 s; LVET = 0.527 ± 0.076 s; LVTES = 0.598 ± 0.098 s and PEP-to-LVET = 0.131 ± 0.01 measured by Doppler ultrasonography.
A Position and Orientation Compensation Mechanism for Automatic Docking Device of Launch Rocket

A position and orientation compensation mechanism for the automatic docking device of a launch rocket-was established.The docking process was simulated, and the maximum docking deviation was used for the prototype testing of the compensation mechanism.The compensation mechanism mainly comprises four column pairmotion branch chains with the same structure.When the position of the ground connector panel changes relative to the moving platform, the sliding rods in the four motion branch chains move and rotate to either compress or stretch the connected spring, thereby compensating the position and orientation. First, the dynamic simulation model of the compensation mechanism was established.The docking process was then simulated under the maximum docking deviation.Bench testing of the automatic docking device prototype was carried out.Afterwards, the device was manufactured, and a maximum load test and maximum deviation test were carried out. The results demonstrate that the compensation mechanism meets the design requirements, and the spring stiffness was found as the most important factor in determining the mechanical properties of the system.The proposed compensation mechanism has a number of advantages, including a simple structure, large load bearing capacity, small size, simple installation, and adjustment.
Frontal Pole Hypometabolism Linked to Reduced Prosocial Sexual Behaviors in Frontotemporal Dementia and Corticobasal Syndrome.

BACKGROUND Changes in sexual behaviors in frontotemporal dementia (FTD) are common and multifaceted, but not well characterized. OBJECTIVE To characterize changes in sexual behaviors and intimacy in FTD compared to corticobasal syndrome (CBS) and normal controls (NC), and to evaluate the neuroanatomical associations of these changes. METHODS Spouses of 30 FTD patients, 20 CBS patients, and 35 NC completed the Sexual Symptoms in Neurological Illness and Injury Questionnaire (SNIQ), which captures changes in sexual interest, inappropriate sexual behaviors, and prosocial sexual behaviors. 25 patients with FTD and 14 patients with CBS also received 18-flouorodeoxyglucose positron-emission topography (18FDG-PET) scans to determine the metabolic changes associated with these symptoms. RESULTS FTD patients showed a greater increase in inappropriate sexual behaviors than CBS patients [p = 0.009] and NC [p < 0.001] and a greater decrease in prosocial sexual behaviors than CBS patients [p = 0.026] and NC [p < 0.001]. Groups did not differ in change in sexual interest. Among both patient groups, the most common change was decreased prosocial sexual behaviors [p < 0.01]. Hypometabolism in Brodmann's Area 10 (BA10), within the right frontal pole, correlated with decreased prosocial sexual behaviors [p(FWE-corr) <0.05, k = 44]. No anatomical associations were found with other sexual changes. CONCLUSION Decreased prosocial sexual behavior was associated with hypometabolism in BA 10, an area tied to social knowledge and theory of mind, supporting the idea that changes reflect social-cognitive deficits due to frontal dysfunction.
Balancing the sexology scales: a content analysis of Black women’s sexuality research

Abstract Existing research adopting a sex positive and intersectional framework for investigating Black women’s sexualities is scarce. We conducted a 46-year (1972–2018) content analysis of sexualities research focussed on Black women. It sought to examine which sexualities topics were published most; whether the publications aligned with sex-positive, neutral or negative discourse; what methodologies were used; and differences in how various identities were investigated among Black women. Using human coding, we applied an integrative approach to the content analysis. Results found 245 articles meeting criteria. Approximately one-third of articles within the analysis focussed on the topic of sexually transmitted infections (STIs), HIV and sexual risk behaviours among Black women. Only 6.5% of articles utilised a sex-positive discourse. Quantitative articles were the most published methodology, and publications disproportionately overlooked Black women’s intersectional identities. Implications for future research and practice are discussed.
A selective serotonin receptor agonist for weight loss and management of menopausal vasomotor symptoms in overweight midlife women: a pilot study.

OBJECTIVE Weight gain and vasomotor symptoms (VMS) are common complaints in midlife women going through the menopause transition. A selective serotonin 2C (5-HT2C) receptor agonist, lorcaserin, which was previously approved by the Food and Drug Administration for weight loss, has unreported observational evidence suggesting improvement in VMS with its use. The goal of this pilot study was to evaluate the efficacy of lorcaserin for weight loss and management of VMS in overweight midlife women. METHODS This was a 24-week open label pilot study of 20 overweight midlife women, aged 45-60 years, who were experiencing severe VMS. Participants received lorcaserin at the standard dose of 10 mg twice daily for 12 weeks, followed by 12 weeks of observation off the drug. The primary outcomes were changes in weight and subjectively reported VMS. RESULTS At the end of 12 weeks, mean change in weight was -2.4 kg (90% CI, -3.2 to -1.7, P < 0.001). However, the participants returned to the baseline weight at 24 weeks. Participants also reported significant subjective improvement in VMS, with a mean ± SD change in self-reported hot flash frequency from baseline to week 12 of -5.4 ± 3.9 (decrease of 1.4 standard deviations). There was a rapid increase in the frequency of VMS within 2 weeks of discontinuation of lorcaserin with a tendency to approach the baseline frequency of VMS. CONCLUSIONS In addition to its weight loss-inducing effect, 5-HT2C receptor modulation may have an additional beneficial effect on VMS in midlife women. A treatment option that targets both weight and VMS in midlife women is attractive. : Video Summary:http://links.lww. com/MENO/A622.
Cardiac Intensive Care

1064 www.pccmjournal. org December 2020 • Volume 21 • Number 12 1Department of Cardiovascular and Critical Care Nursing Services, Boston Children’s Hospital, Boston, MA. 2Department of Cardiology, Boston Children’s Hospital, Boston, MA. 3Information Services Department, Clinical Integration Architect, Boston Children’s Hospital, Boston, MA. 4Department of Pediatrics, Harvard School of Medicine, Boston, MA. 5Department of Cardiovascular Services, Boston Children’s Hospital, Boston, MA. 6Department of Family and Community Health, School of Nursing, University of Pennsylvania, Philadelphia, PA. 7Department of Anesthesia and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. 8Research Institute, Children’s Hospital of Philadelphia, Philadelphia, PA. Copyright © 2020 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies Objectives: To assess the impact of a nurse-implemented goaldirected sedation strategy on patient care and nursing practice in a pediatric cardiac ICU. Design: Quality improvement project with a pre-post interval measurement plan. Setting: Thirty-one bed pediatric cardiac ICU in a freestanding tertiary care children’s hospital. Patients: Postoperative pediatric cardiac surgery patients. Interventions: The implementation of cardiac-Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE), a nurseimplemented goal directed strategy to improve pain and sedation management in a pediatric cardiac ICU which included daily team discussion of the patient’s trajectory of illness (acute, titration, or weaning phase), prescription of a sedation target score based on the patient’s trajectory of illness, arousal assessments, and opioid and/or sedative titration. Withdrawal Assessment Scores were used to assess and manage iatrogenic withdrawal symptoms. Measurements and Main Results: Data related to opioid and sedation use, pain and sedation scores, and the occurrence and management of iatrogenic withdrawal symptoms were reviewed on 1,243 patients during four separate time periods: one pre-implementation and three discontinuous post-implementation time intervals. Patient age and complexity were consistent across the data collection periods. Post-implementation opioids and benzodiazepines use was reduced about 50% without a concomitant increase in the use of other sedative classes. Few post-intervention patients were discharged from the pediatric cardiac ICU or to home on methadone (pediatric cardiac ICU: pre 19% to post 3%; hospital: pre 12% to post 1.3%). Documentation of pain, sedation, and withdrawal scores became more consistent and nurses reported satisfaction with their patient’s comfort management. Conclusions: The implementation of a nurse-driven goal-directed plan such as cardiac-RESTORE to manage pediatric cardiac ICU patient pain and sedation is possible, sustainable, and associated with reduced sedative and methadone use. (Pediatr Crit Care Med 2020; 21:1064–1070)
Storage Area Network Architecture to support the Flexibility of Digital Evidence Storage

Cybercrime is a criminal activity that utilizes computers and the internet as a media in committing its crimes. In solving the case of cybercrime, it is useful with the help of digital forensics. The critical component in digital forensics is electronic evidence that has a physical form and digital evidence that has form in the binary file. Both types of evidence require handling in the storage process with different treatments. In this case, physical evidence of physical nature will be stored in the evidence room while digital evidence will be stored in evidence storage. The solution that has existed so far is through the mechanism of storing digital evidence stored in evidence storage based on internal storage with limited accessibility to one device. It causes inflexibility and effectiveness to support collaborative efforts between officers and law enforcement in the process of investigating and handling digital evidence. This research is to develop previous research on digital evidence storage and handling systems. This paper presents a solution for centralized and network-based digital evidence storage architecture to address the weaknesses of previously available solutions. Flexibility repositories based on SAN (Storage Area Network) and web-based technology are used as network-based
Intravenous sodium valproate for acute migraine in the emergency department: A meta‐analysis

The role of intravenous sodium valproate (iVPA) in acute migraine attack has not been completely established. The aim of this updated review was to evaluate the efficacy and safety of iVPA in patients with acute migraine in the emergency department. We searched the PubMed, Web of Science, and Cochrane Library databases for relevant randomized controlled trials (RCTs). The primary outcome was improvement of headache intensity and headache relief. The need for rescue therapy, recurrence of headache, and number of adverse events was also assessed. Seven double‐blinded RCTs involving 682 patients were analyzed. Overall, patients receiving iVPA had less improvement of headache intensity (SMD: −0.39, 95% CI: −0.73 to −0.06, P = .02) and lower rate of headache relief (OR: 0.51, 95% CI: 0.33 to 0.77, P = .002) than those receiving other active comparators. In addition, iVPA increased the odds of rescue therapy compared with other active drugs (OR: 3.76; 95% CI: 1.96 to 7.20, P < .0001). Subgroup analysis showed that iVPA was comparable to dexamethasone, with similar improvement of headache intensity, and recurrence of headache. For migraine without aura, we found no significant difference in headache intensity improvement when iVPA was compared with active comparators (SMD: −0.00, 95% CI: −0.54 to 0.54, P = 1.00). iVPA was inferior to the studied comparators and was comparable to dexamethasone for aborting migraine attack. Based on the available evidence, iVPA may be a reasonable alternative or salvage therapy. In particular, iVPA might be a promising agent for migraine with aura and migraine status.
Preparation of synthetic antigen and monoclonal antibody for indirect competitive ELISA of citrinin

Abstract Citrinin (CIT)-protein synthetic antigen was prepared by conjugating CIT with keyhole limpet hemocyanin by 1,4-butanediol diglycidyl ether. The ultraviolet and infrared spectrometry analyses indicated that CIT was conjugated with the carrier protein successfully. By fusion and cloning, a hybridoma cell line K2-F3 which stably secreted the highly specific monoclonal antibody (McAb) against CIT was obtained. The indirect competitive ELISA showed that the IC50 value was 0.3 ng/mL and the limit of detection, 0.01 ng/mL. Cross-reactivity was less than 0.01% with four mycotoxins, aflatoxin B1, ochratoxin A, zearalenone, deoxynilvalenol and three pigments, rubropunctatine, rubropunctamine, monascin. The mean recovery of citrinin from artificially contaminated red yeast rice was from 89 to 92%, with CVs from 6.8 to 9.0%. The ELISA developed in this study can accurately determine CIT in artificially contaminated red yeast rice.
Surveillance of Type 1 Ostreid Herpesvirus (OsHV-1) Variants in Japan

Ostreid herpesvirus 1 (OsHV-1) m Var is a variant of OsHV-1 and suspected of being the causative agent of acute mass mortality events of Pacific oysters during summers in Europe since 2008. In this study, the distribution of OsHV-1 was surveyed in the six main oyster-producing areas of Japan, using PCR targeting a C2/C6 fragment including ORF4. PCR products were amplified from 123 out of 1,714 oysters of three species of Crassostrea (C. gigas, C. sikamea and C. ariakensis), and 23 diferent nucleotide sequences, showing 96% to 99% similarity to the reference OsHV-1, were obtained. Although 18 sequences among the 23 obtained possessed a microsatelite deletion unique to OsHV-1 m Var, al PCR products contained two conserved nucleotides that were shared with the reference OsHV1 and not with OsHV-1 m Var. Here, we found variable types of OsHV-1 in oysters in Japan, but their nucleotide sequences were not identical to those of OsHV-1 m Var.
Prepared but unprepared: a qualitative study of provider perspectives on the preparation and adjustment of U.S. families who internationally adopt children with HIV

ABSTRACT An increasing number of U.S. families are adopting children with HIV born outside the country. This exploratory qualitative study seeks to understand providers’ perspectives on international adoptee and family preparation and adjustment to life in the U.S. Eleven psychosocial and five medical care providers participated in hour-long, semi-structured, recorded interviews focused on their experiences caring for internationally adopted children with HIV (IACH) and their adoptive parents. Transcribed interviews were analyzed to identify emergent themes. Providers described considerable variation among families who adopted children. Some had grown biological children and several adopted multiple children with special needs. Most were connected to communities of faith which served as an inspiration to adopt and offered support. Serious medical and HIV-related issues were minimal. Psychosocial concerns were more common and included attachment, adjustment, and behavioral issues. Participants noted that adoptive parents were well informed about HIV, but less prepared for cognitive delays and emotional challenges. Some providers experienced or expected to have challenges offering sexual and reproductive health education to adolescents due to their adoptive parents’ religious beliefs on sexuality. Additional support managing behavioral and emotional challenges, as well as sexual education, may be needed especially as IACH transition into adolescence and young adulthood.
Artificial Neural Networks in Fixed Income Markets for Yield Curve Forecasting

The yield curve is the centrepiece in bond markets, a massive asset class with an overall size of USD100 trillion that remains relatively under-investigated using machine learning. This paper is the first comprehensive study using artificial neural networks in the context of yield curve forecasting. Specifically, two models were used for forecasting the European yield curve: multivariate linear regression and multilayer perceptron (MLP), at five forecasting horizons, from next day to 20 days ahead. Five variants of the MLP were analysed with different sets of features: target to predict (univariate); the most relevant features; all generated features; and the former two incorporating synthetic data generated by the linear regression model. Additionally, two different techniques of multitask learning were employed: simultaneous modelling and transformation into multiple single task learning. The results show that considering all forecasting horizons, the MLP using the most relevant features achieved the best results and the addition of synthetic data tends to improve accuracy. Furthermore, different targets and forecasting horizons resulted in different relevant features, reinforcing the importance of custom-built models. In the two multitask learning methodologies no clear differentiation could be demonstrated, and several explaining factors are identified. Overall, the outcome is very encouraging for the development of better forecasting systems for fixed income markets.
Salt and water balance of modern baleen whales: rate of urine production and food intake

Whales, as pelagic marine mammals, are thought to have evolved from fresh-water-dependent terrestrial mammals. Baleen whales feed primarily on salty euphausiids (krill) and have no access to fresh water. How have these mammals adapted to lifelong habitation in a hyperosmotic medium? A new approach is proposed for studying this by using allometry (scaling) of endogenous creatinine clearance in mammals together with determinations of creatinine concentration in fresh postmortem blood and urine of fin whales (Balaenoptera physalus) and sei whales (Balaenoptera borealis). From the predicted mean creatinine-clearance values and the measured mean creatinine concentrations, a urine-production rates of 974 and 627 L/day for the fin and sei whales, respectively, were computed. Average daily krill ingestion of about 1300 and 835 L is predicted for the fin and sei whales, respectively. The whales seem to ingest about 30% more than earlier reported of a prey, which has about 50% of the salt concentration of seawater,.