AND IN PSYCHOSIS

revealed significant group x response interaction (F(1,63)=7.8, p<0.05), with post-hoc independent t-test showing that patients significantly pre-ferred safe over risky options than controls (t=2.6, p<0.05). There were no significant correlations of risky decision-making parameters with symptom ratings and cognitive functions. Discussion: We extend previous findings of chronic samples to patients with early schizophrenia-spectrum disorder and indicate that suboptimal risky decision-making with risk-aversion preference has also been observed in the early course of illness. Further research is warranted to clarify the longitudinal change of aberrant risk-aversive behavioral patterns and its relationship with prospective functional and symptom outcomes. Background: Primary negative symptoms of schizophrenia contribute heav- ily to functional disability. Treatment of these symptoms continues to be a major unmet need, even when positive symptoms are controlled. Recent factor analyses of negative symptoms using the PANSS and other symptom assessments in patients with schizophrenia have identified two factors of negative symptoms: expressive and experiential deficits. These two factors most likely have very different clinical, neurocognitive and neurobiological correlates. This study examines the clinical and cognitive correlates associ- ated with expressive and experiential deficits in a large cohort of patients with psychosis before and after computerized cognitive remediation. Methods: This is a secondary data analysis of subjects enrolled in a cog- nitive remediation program for 12 weeks. One hundred fifty-one subjects age 18 - 55 with a DSM IV-TR diagnosis of schizophrenia, schizoaffec- tive disorder or bipolar disorder were enrolled. Assessments of demo-graphic, at endpoint. factor analyses of were examined at Background: Although the deficits of empathy in schizophrenia spectrum disorders has been recognized in previous studies, little is known about the associations between empathy and schizotypal traits. In this study, we examined the associations among empathy, schizotypy and affective states using the psychological network analysis in a college sample to better understand the social cognition deficits in schizophrenia. Methods: College students (n=1486; male = 574, female = 912; mean age=18.8 years; SD=0.85) were recruited and all of them finished self- reported questionnaire capturing empathy (Interpersonal Reactivity Index, IRI; four subscales: perspective taking, empathic concern, fantasy, per- sonal distress), schizotypy (Wisconsin Psychosis Proneness Scales, includ-ing social anhedonia, physical anhedonia, magical ideation and perceptual aberration scales) and affective states (Depression, Anxiety and Stress Scale, 21 items). There were significant sex differences on IRI (female > male for all four subscales, ps < 0.01), DASS depression (male > female, p < 0.01) and schizotypal traits (male > female, ps < 0.05) Psychological networks were constructed taking the subscales of measures as nodes and the edges representing the partial correlation between each pair of nodes controlling all other nodes were estimated using Gaussian graphical model in male and female sample, respectively. Also, the centrality indices, includ-ing strength, closeness and betweenness were calculated to identify the cen- tral nodes in the network. Results: In males, cognitive empathy (perspective taking and fantasy) showed strong connections with physical anhedonia, while affective empathy (empathic concern) connected with social anhedonia and stress. Personal distress connected with magical ideation and anxiety; fantasy connected with magical ideation. Regarding the centrality, perceptual aberra- tion had the strongest strength, followed by stress; social anhedonia had the highest closeness and betweenness. In females, cognitive empathy (perspec- tive taking and fantasy) showed strong connection with physical anhedonia, affective empathy (empathic concern) connected with social anhedonia. Personal distress connected with anxiety; fantasy connected with magical ideation. Stress showed strongest strength, followed by anxiety and magical ideation; anxiety had highest betweenness; fantasy had highest closeness followed by social anhedonia. Discussion: In the present study, we found that cognitive empathy was strongly connected with physical anhedonia, while affective empathy connected with social anhedonia, regardless of sex. In addition, our findings suggested different network interactions among empathy, schizotypal traits and affective states between males and females. The perceptual aberration and social anhedonia play a central role in the network of males while stress and anxiety are important in females. of schizophrenia compare neurocognitive abilities in children of parents with bipolar disorder abilities in children of without Methods: In this nationwide cohort study we assessed 522 7-year-old child- ren (schizophrenia offspring: N=202, bipolar offspring: N=120, and con-trols=200) with a detailed and well validated neurocognitive test battery. We compared the neurocognitive test scores of the three study groups. Results: Children of parents with schizophrenia showed neurocognitive deficits, whereas children of parents with bipolar disorder displayed neuro- cognitive abilities comparable to the control group.