Miracle-dz/UniFAR-FTUs huggingface dataset:
Action Mechanism Underlying Improvement Effect of Fuzi Lizhong Decoction on Nonalcoholic Fatty Liver Disease: A Study Based on Network Pharmacology and Molecular Docking

Objective This study aimed to decipher the bioactive compounds and potential mechanism of traditional Chinese medicine (TCM) formula Fuzi Lizhong Decoction (FLD) for nonalcoholic fatty liver disease (NAFLD) treatment via an integrative network pharmacology approach. Methods The candidate compounds of FLD and its relative targets were obtained from the TCMSP and PharmMapper web server, and the intersection genes for NAFLD were discerned using OMIM, GeneCards, and DisGeNET. Then, the PPI and component-target-pathway networks were constructed. Moreover, GO enrichment and KEGG pathway analysis were performed to investigate the potential signaling pathways associated with FLD's effect on NAFLD. Eventually, molecular docking simulation was carried out to validate the binding affinity between potential core components and key targets. Results A total of 143 candidate active compounds and 129 relative drug targets were obtained, in which 61 targets were overlapped with NAFLD. The PPI network analysis identified ALB, MAPK1, CASP3, MARK8, and AR as key targets, mainly focusing on cellular response to organic cyclic compound, steroid metabolic process, and response to steroid hormone in the biological processes. The KEGG pathway analysis demonstrated that 16 signaling pathways were closely correlated with FLD's effect on NALFD with cancer pathways, Th17 cell differentiation, and IL-17 signaling pathways as the most significant ones. In addition, the molecular docking analysis revealed that the core active compounds of FLD, such as 3′-methoxyglabridin, chrysanthemaxanthin, and Gancaonin H, had a high binding activity with such key targets as ALB, MAPK1, and CASP3. Conclusions This study suggested that FLD exerted its effect on NAFLD via modulating multitargets with multicompounds through multipathways. It also demonstrated that the network pharmacology-based approach might provide insights for understanding the interrelationship between complex diseases and interventions of the TCM formula.
The Practice of Periodic Safety Review in France

Periodic safety review(PSR)is implemented for nuclear power plants in the world in order to improve the safety level continuously. The practice of PSR in France is very distinctive. This paper main- ly introduces French practice and the project of VD3-900, including the approach, the history, the achievement and the current situation of PSR. In the paper the practices of PSR in other countries are presented briefly.
Six Sigma for Technical Processes: An Overview for R&D Executives, Technical Leaders and Engineering Managers (Prentice Hall Six Sigma for Innovation and Growth Series)

Use Six Sigma to achieve and sustain excellence in product development and commercialization! To sustain growth and profitability, companies must tightly align product development and commercialization to fast-changing customer requirements. In this book, Clyde Creveling identifies the four process areas most crucial to doing so-and shows executives and managers how to optimize each of them.Creveling introduces a Six Sigma-enabled workflow that encompasses strategic product/technology portfolio definition and development, research and technology development (R&TD), tactical design engineering processes for commercialization, and operational production and service support. He presents tools, methods, and best practices for selecting the right projects, prioritizing them, and executing them rapidly, consistently, and successfully. i? Integrate all key technical processes so they work together in harmony i? Create Phase/Gate control plans for delivering products with minimal risk i? Establish scorecards for risk management in technical processes Use Six Sigma tools, such as Monte Carlo and FMEA, to improve project management Bring discipline to your product and technology portfolio renewal processes Systematically optimize your commercialization processes Define stripped-down “Fast Track” processes for commercializing high-risk, high-reward opportunities Provide effective operational support after you launch your product Preview the future of “lean” and Six Sigma in technical processes Use lean techniques to streamline repeatable processes such as R&D, product design, and post-launch production engineering support Learn how to manage the risk of doing a fast track commercialization project when you really must cut corners to get a product out into the market before your opportunity evaporatesForeword by John Boselli i? xiiiPreface i? xvAbout the Author i? xxiChapter 1: Introduction to Six Sigma for Technical Processes i? 1Chapter 2: Scorecards for Risk Management in Technical Processes i? 21Chapter 3: Project Management in Technical Processes i? 35Chapter 4: Strategic Product and Technology Portfolio Renewal Process i? 51Chapter 5: Strategic Research and Technology Development Process i? 95Chapter 6: Tactical Product Commercialization Process i? 163Chapter 7: Fast Track Commercialization i? 275Chapter 8: Operational Post-Launch Engineering Support Processes i? 293Chapter 9: Future Trends in Six Sigma and Technical Processes i? 317Glossary 323Index 351
Industry 4.0 for Thai SMEs: Implementing Open Innovation as Innovation Capability Management

The challenges of cooperation and collaboration faced by small and medium-sized enterprises (SMEs) in Thailand require a specific approach to creating new shared value through innovation — open innovation is extensively applied. The purpose of this research is to shape the psychometric properties of an Open Innovation Implementation scale that supports a four-dimensional factor model incorporating centralization, knowledge management, the technology transfer evaluation process, and networks. A sample of 373 SMEs was used for second-order analysis. The results provided evidence indicating the significant relationship between shaping the concept of Open Innovation Implementation (OII), implying that SMEs should therefore consider the managerial and organizational dimensions of implementing open innovation. In addition, our findings offer manufacturing SMEs the strategic opportunity to innovate via interaction with relevant stakeholders, such as industries, universities, government, and customers/users, to stay competitive.
POSSIBLE MUTATION PATHWAYS IN SARS-CoV-2

Mutations are the best way to generate genetic variation, as they provide the raw material in which evolutionary forces, like natural selection, can act. However, mutations are not always able to change the apparent behaviour of an organism, instead, they are capable of providing normal and abnormal biological functions. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a new and controversial biological scenario. Despite the hundreds of studies performed, to date, there is no specific treatment available. Several genomic and non-genomic mutations have been also reported, and due to its high genome size and mutation capacity, it can acclimatize to variable environments and has become the leading cause of high infection and mortality rates. This review outlines the possible pathways behind SARS-CoV-2 mutations.
DATA QUALITY IN WEB APPLICATIONS : A STATE OF THE ART

The technological advance and the internet have favoured the appearance of a great diversity of web applications through which organizations develop their businesses in a more and more competitive environment. A decisive factor for this competitiveness is the assurance of data quality of the web applications used. In the last years, several research works on Data Quality have been developed. In this paper, we will present a systematic review of those researches.
Recognition of Seat Elements during Production through Image Processing

The primary aim of the research, whose results are presented in this article, was to investigate the process of visual identification of objects. The objects recognised under this research were passenger seats for mass transit applications. The system presented in this paper is intended to be incorporated in the production process control system. The problem under analysis is based on the need to recognise (identify) an object located in the process area of the machine before proceeding with the process. Neural network was chosen as the adaptive element due to a high degree of similarity between the semi-products. The function of the network was to check if correct element had been fed. The input data fed to the network was the information from processing the photo images of these elements. The results of research as presented in this article are based on a limited set of elements and present the method used for solving the task of identification.
Improvement of Current Gain and Breakdown Voltage in 4H-SiC BJTs Employing High-k Dielectric as an Interfacial Layer

This paper proposes a new structure of 4H-SiC bipolar junction transistor, which can both achieve high current gain and high open base breakdown voltage. By introducing a groove type of metal-high k dielectric-silicon carbide (MIS) structure into the active region along the base-emitter sidewall which is formed with the process of isolation etching, a large electric field appears at the interface between high-k dielectric and bulk material by analyzing the potential distribution in forward mode, thus accelerating the electron transport. Based on a doping concentration of 4×1017cm-3 and thickness of 0.6um base region, current gain of as high as 191 is obtained using TCAD simulation, and that is almost double of the conventional structure in the same simulation setup. Furthermore, a field plate structure is composed combined with the base contact metal simultaneously, and the open base breakdown voltage is obviously increased from 634V to 948V with a 6μm-thick n-SiC collector (Nd=3×1015cm-3).
Efficient, scalable traffic and compressible fluid simulations using hyperbolic models

This thesis presents novel techniques for efficiently animating compressible fluids and traffic flow to improve virtual worlds. I introduce simulation methods that recreate the motion of coupled gas and elastic bodies, shockwaves in compressible gases, and traffic flows on road networks. These can all be described with mathematical models classified as hyperbolic —models with bounded speeds of information propagation. This leads to parallel computational schemes with very local access patterns. I demonstrate how these models can lead to techniques for physically plausible animations that are efficient and scalable on multi-processor architectures. Animations of gas dynamics, from curling smoke to sonic booms, are visually exciting. Existing computational models of fluids in computer graphics are unsuitable for properly describing compressible gas flows—I present a method based on a truly compressible model of gas to simulate two-way coupling between gases and elastic bodies on simplicial meshes that can handle large-scale simulation domains in a fast and scalable manner. Computational models of fluids used so far in graphics are inappropriate for describing supersonic gas dynamics because they assume the presence of smooth solutions. I present a technique for the simulation of explosive gas phenomena that addresses the challenges found in animation—namely stability, efficiency, and generality. I also demonstrate how this method is able to achieve near-linear scaling on modern many-core architectures. Automobile traffic is ubiquitous in modern life; I present a traffic animation technique that uses a hyperbolic continuum model for traffic dynamics and a discrete representation that allows visual depiction and fine control. I demonstrate how this approach outperforms agent-based models for traffic simulation. Additionally, I couple discrete agent-based vehicle simulation to continuum traffic. My hybrid technique captures the interaction between arbitrarily arranged regions of a road network and dynamically transitions between the two models. I present an analysis of the impact my hybrid technique on the ability of simulation to mimic real-world vehicle trajectory data. The methods presented in this dissertation use hyperbolic models for natural and man-made phenomena to open new possibilities for the efficient creation of physically-based animations.
Cerebral Phospho-Tau Acts Synergistically with Soluble Aβ42 Leading to Mild Cognitive Impairment in AAV-AD Rats

Alzheimer’s disease (AD) is a continuum of events beginning with an increase in brain soluble Aβ342 followed by the appearance of hyperphosphorylated tau (P-tau, asymptomatic stage). Mild Cognitive Impairment (MCI) then appears (prodromal stage). However, the individual contribution of these two soluble proteins in the onset of the first cognitive symptoms remains unclear. We sought to understand the specific impact of p-tau on the development of MCI in the AAV-AD rat model, a model of late-onset Alzheimer’s disease (LOAD) predementia. We specifically reduced the phosphorylation level of tau while leaving Aβ342 levels unchanged using a DYRK1A protein kinase inhibitor, Leucettine L41, in an adeno-associated virus-based Alzheimer’s disease (AAV-AD) rat model. Leucettine L41 was administered by intraperitoneal injection at 20 mg/kg per day in AAV-AD rats from 9 (late asymptomatic phase) to 10 (prodromal phase) months of age. Decreased soluble forms of P-tau induced by chronic administration of Leucettine L41 did not change soluble Aβ342 levels but prevented MCI onset in 10-month-old AAV-AD rats. The present study argues that P-tau is required to induce the development of MCI. Consistent with our previous findings that soluble Aβ342 is also required for MCI onset, the data obtained in the AAV-AD rat model confirm that the transition from the asymptomatic to the prodromal stage may be caused by the combined presence of both soluble brain forms of Aβ342 and p-tau, suggesting that the development of MCI may be the consequence of their synergistic action.
CDMA2000, W-CDMA and IDMA: An Overview

Now-a-days, various multiple access schemes have attracted attention of researchers and have near Shannon limit performance in multi-user environment. Few of them are in application while others are under development for future application. This paper discusses the basic principals of these advanced multiple access schemes named CDMA2000, Wideband-CDMA (W-CDMA), and Interleave Division Multiple Access (IDMA) scheme. So, in this paper an overview of CDMA2000, W-CDMA, and IDMA is presented and also discuss the main features and areas of application as the future air interface access schemes for IMT-2000/UMTS.
Effect of Mulligan Mobilization on Proprioception in Osteoarthritis of Knee Joint - A Systematic Review

Background: Osteoarthritis (OA) of the knee is a degenerative disorder that affects the joint which causes pain, stiffness, swelling, muscle weakness, and functional impairments. Proprioception in the OA knee seems to be impaired when compared with the normal counterparts. Manual therapy is one of the hands-on therapies delivered by physiotherapists. However, there is not much information on how manual therapy affects joint proprioception, although some studies show a positive response. Mulligan’s mobilization technique is common for spinal and peripheral joints to correct positional faults. Aim: To systematically identify and to evaluate the effects of mulligan mobilization on the proprioception of the OA knee. Methods: Various electronic databases like PubMed Central, Medline, Google Scholar, ProQuest and CINAHL are searched from 2001 to 2021. Multiple search criteria were used in the search of relevant articles based on the selection criteria used. Four articles that fit the criteria were taken based on the PEDro Scores of above 5. The two specialists analysed all the papers. The articles which cover mulligan’s mobilization and proprioception of the knee were only selected. Results: Four articles that fit the criteria were reviewed which demonstrated baseline comparability and reported point estimates and measures of variability. Conclusion: This systematic review has concluded that the knee joint proprioception was improved with applying the Mulligan’s manual therapy, whereas the neurophysiological activity is not well understood.
Water distribution network modelling of a small community using watercad simulator

In this study a network model was constructed for the hydraulic analysis and design of a small community (Sakwa) water distribution network in North Eastern geopolitical region of Nigeria using WaterCAD simulator. The analysis included a review of pressures, velocities and head loss gradients under steady state average day demand, maximum day demand conditions, and fire flow under maximum day demand using average day demand of 60 lpcd.The results indicate: that the tower height of the existing storage tank is inadequate and should be increased from 10m to 15m to provide satisfactory service, and that there are no areas of concern with respect to pressure or available fire flow for the proposed service area and also that flow velocities are not excessive while head loss gradients in the network are within acceptable limits. Pipes P-6, P-12, P-15 and P-19 expectedly have relatively low flow velocities due to the low average day demands in small communities and the constraint of minimum commercially available pipe sizes makes design of self cleansing networks in such communities not easily realizable.
Cathodoluminescence mapping of electron concentration in MBE-grown GaAs:Te nanowires

Cathodoluminescence mapping is used as a contactless method to probe the electron concentration gradient of Te-doped GaAs nanowires. The room temperature and low temperature (10 K) cathodoluminescence analysis method previously developed for GaAs:Si is first validated on five GaAs:Te thin film samples, before extending it to the two GaAs:Te NW samples. We evidence an electron concentration gradient ranging from below 1 × 1018 cm−3 to 3.3 ×1018 cm−3 along the axis of a GaAs:Te nanowire grown at 640 °C, and a homogeneous electron concentration of around 6–8 × 1017 cm−3 along the axis of a GaAs:Te nanowire grown at 620 °C. The differences in the electron concentration levels and gradients between the two nanowires is attributed to different Te incorporation efficiencies by vapor–solid and vapor–liquid–solid processes.
360 Degrees PMS Tool: Reservations and Concerns in Application

The main aim of the study is to analyze the effectiveness of 360-degree performance appraisal feedback system in Ogaan Publications and Conde Nast Publications. Performance evaluation techniques are often driven by a desire to minimize disagreement across evaluations. Historically, the typical goal of maximizing agreementis based on the assumption that there exists an objective reality that will be similarly perceived and reported, despite differences in rater perspective. Thus disagreement-a failure ofinter subjective verification-is typically considered rater error. In order to accomplish this, study on 360 Degree PMS was conducted and a methodological mix was chosenso that impact could be documented quantitatively. Quantitative datawas collected from a samplesize of 70 participants.
Assessment of Ageing Conditions Through Paper Tensile Strength Analysis of Scrapped Transformers

With the increasing population of transformers whose service ages are approaching or in excess of their designed lifetime, it is of critical importance for asset managers to evaluate these transformers' ageing conditions, to determine reasonable end-of-life criteria and to make medium/long term replacement plan. In order to support the above tasks, numerous laboratory- ageing studies have been conducted. However, interests in forensic examinations of scrapped old transformers have increased in recent years since it could provide the ultimate 'under-service' ageing information. Paper tensile strength results of three scrapped transformers were analyzed in this paper. Paper TS data were mapped vertically to give an indication of overall ageing condition of the winding, and they were mapped horizontally across phases and windings, to examine transformer thermal design. The results demonstrate that there are different dominating ageing/degradation processes at winding locations and layers of paper of the same conductor.
Experimentally determined effect of swirl on the performance of a rotodynamic pump

Pre-swirl in the approach flow towards a pump leads to a decreased efficiency or even to malfunctioning of a pump. Especially for pumping stations with large rotodynamic pumps, the risk of malfunctioning should be minimized. For this reason, hydraulic investigations are performed prior to the construction of pumping stations to assess the amount of pre-swirl in the approach flow and if needed, to design local measures to decrease it. This article presents a test set-up of a simplified pump sump in which the pump performance characteristics are measured at a real pump for a wide range of predefined corotating and counterrotating swirl angles. The swirl angles are measured in a transparent model pump at scale 1:1 with a swirl meter at four bell diameters above the bell-mouth. The findings discussed in this paper provide insight in the relation between pre-swirl in the approach flow and pump performance.
PROSPECTS FOR CONTINUOUS ORIGIN-DESTINATION MATRIX ESTIMATION

In complex networks, there is always risk that some detectors may be unserviceable, or traffic temporarily disrupted by incidents, so Origin-Destination Matrix Estimation (ODME) must be made as robust as possible. This can be achieved by data redundancy, and by screening data to remove anomalous values which could contaminate or frustrate solutions. This paper discusses a practical instance of OD estimation on the English M42 motorway during a period when data collection was affected by construction work, the implementation of a method of analysing and screening the data, and the relationship between data quality and the prospect of obtaining solutions.
Channel morphodynamics and sediment budget of the Lower Ganga River using a hydrogeomorphological approach

The Ganga River is one of the largest river systems in the world that has built extensive alluvial plains in northern India. The stretch of the Lower Ganga River is vulnerable to siltation because of: (a) the naturally low slope in the alluvial stretch; (b) the confluence of several highly sediment‐charged rivers such as the Ghaghra, Gandak, and Kosi; and (c) the reduction in non‐monsoon flows because of upstream abstractions of both surface and groundwater. Additionally, the Farakka barrage has impacted the morphology of the Ganga River significantly, both upstream and downstream of the barrage. Large‐scale siltation in several reaches has reduced the channel capacity, leading to catastrophic floods in this region even at low discharges. This work has utilized historical remote sensing data and UAV surveys to reconstruct channel morphodynamics and compute sediment volumes accumulated in the channel belt along the Lower Ganga River between Buxar and Farakka. The work was carried out by dividing the total length of the river into four continuous stretches: (a) Buxar–Gandhighat (GW1, 160 km); (b) Gandhighat–Hathidah (GW2, 106 km); (c) Hathidah–Azmabad (GW3, 182 km); and (d) Azmabad–Farakka (GW4, 132 km). We document that major ‘hotspots’ of siltation have developed in several reaches of the Lower Ganga during the last four to five decades. Sediment budgeting using planform maps provides estimates of ‘extractable’ volumes of sediment in GW1, GW2, GW3, and GW4 as 656 ± 48, 706 ± 52, 876 ± 71, and 200 ± 85 Mm3, respectively. These estimates are considerably lower than those computed from the hydrological approach using observed suspended sediment load data, which assumes uniform sedimentation between two stations. Further, our approach provides reach‐scale hotspots of aggradation and estimates of extractable sediment volumes, and this can be very useful for river managers to develop a strategic sediment management plan for the given stretch of the Ganga River.