Miracle-dz/UniFAR-FTUs huggingface dataset:
Cadms/SynCAMs/Necls/TSLCs Interact with Multi-PDZ Domain Protein MUPP1

Cell adhesion molecules determine the cell-cell binding and the interactions between cells and extracellular signals. Cell-cell junctional complexes, which maintain the structural integrity of tissues, consist of more than 50 proteins including multi-PDZ domain protein 1 (MUPP1). MUPP1 contains 13 postsynaptic density-95/disks large/zonula occludens-1 (PDZ) domains and serves a scaffolding function for transmembrane proteins and cytoskeletal proteins or signaling proteins, but the mechanism how MUPP1 links and stabilizes the juxtamembrane proteins has not yet been elucidated. We used the yeast two-hybrid system to identify proteins that interact with PDZ domains of MUPP1. We found an interaction between MUPP1 and cell adhesion molecule 1 (Cadm1, also known as SynCAM1, Necl-2, or TSLC1). Cadm1 bound to the second PDZ domain of MUPP1. The carboxyl (C)-terminal end of Cadm1 has a type II PDZ-association motif (-Y-F-I) which was essential for the interaction with MUPP1 in the yeast two-hybrid assay. MUPP1 also bound to the C-terminal cytoplasmic tail region of other Cadm family members (Cadm2, Cadm3, and Cadm4). In addition, these protein-protein interactions were observed in the glutathione S-transferase (GST) pull-down assay and by coimmunoprecipitation. Anti-MUPP1 antibody co-immunoprecipitated Cadm1 and Cadm4 with MUPP1 from mouse brain extracts. These results suggest that MUPP1 could mediate interaction between Cadms and cytoskeletal proteins.
The Causal Relationship of the Social Support and Maladaptive Perfectionism with the Academic Burnout Mediated by the Self-Efficacy among Undergraduate Students of Shahid Chamran University

The aim of this research was to investigate the causal relationship between the social support and maladaptive perfectionism on the one hand and the academic burnout mediated by the self-efficacy in the undergraduate students of Shahid Chamran University. The statistical population of research was included all students of the semester 5 upward of Shahid Chamran University of Ahvaz. The reason for selecting the students of the semester 5 upward was that the academic burnout is created over time. For sampling at first the cluster method was used and then the relative stratified sampling method and finally 520 samples in total were analyzed. To measure the research variables the Maslach burnout inventory - student survey, the social support of Malecki, Damary and Elliott, perfectionism of Stoeber and the general Self-efficacy of Scherer were applied and for analyzing the data the path analysis method was used. The results showed that the presented model has a good fitness. Explanations related to the hypotheses and the proposed pattern were discussed, the restrictions were mentioned and practical suggestions also were provided. DOI: 10.5901/mjss.2016. v7n4S1p11
The equivalence of Single-Topic and LDA topic reconstruction

In this paper we show the equivalence between two very diﬀerent document generative models for the task of topic reconstruction. The ﬁrst is the inﬂuential Latent Dirichlet Allocation (LDA) model, while the second is the seemingly much simpler Single Topic model. This is achieved via a reduction between these two generative models that shows that the set of latent topics is identiﬁable under LDA if and only if it is identiﬁable under Single Topic. We then explore some of the consequences of this equivalence by giving tight impossibility results for LDA topic reconstruction. When documents are generated under LDA, the set of latent topics is identiﬁable if and only if the length of the documents is at least the number of topics. To our knowledge, these are the ﬁrst impossibility results for LDA topic reconstruction.
Evaluation of a site conservation rating system in southeastern Arizona.

The objectives of this study were to identify a Site Conservation Threshold, the point at which accelerated erosion occurs, and to examine the usefulness of the Water Erosion Prediction Project (WEPP) model in determining the Site Conservation Threshold on a clay loam upland rangeland site. Sixteen sample sites were chosen to represent a wide range of species composition, ground cover, biomass and apparent soil stability to determine which of these factors could be used to evaluate the site conservation status of a clay-loam upland ecological site on a southern Arizona semi-arid desert grassland. A Site Stability Rating based on observable vegetation and soil-surface characteristics (i.e. ground surface cover and distribution of plants) was developed. A Site Stability Rating was estimated for 100 quadrats per sample site and averaged for the entire sample site. The Water Erosion Prediction Project model was used as an objective index of soil stability to assess the degree of site protection. The Soil Conservation Service soil loss tolerance value (T) was used with the sediment yield predicted by the WEPP model to establish a threshold value for the Site Stability Rating. The objective measures of standing biomass, basal cover, average distance to the nearest perennial plant, and frequency of quadrats with no rooted perennial plant showed strong relationships to the subjective Site Stability Rating. Site Conservation Thresholds were identified for standing biomass (750 kg/ha), basal cover (8%), average distance to the nearest perennial plant (15 cm), and frequency of quadrats (20 X 20 cm) with no rooted perennial plant (13%).
Vector based semantic analysis reveals absence of competition among related senses

Previous research demonstrated that processing time was facilitated by number of related word senses (polysemy) and inhibited by number of unrelated word meanings (homonymy). The starting point of this research were the findings described by Moscoso del Prado Martin and colleagues, who offered a unique account of processing of two forms of lexical ambiguity. By applying the techniques they proposed, for the set of strictly polysemous Serbian nouns we calculated ambiguity measures they introduced. Based on the covariance matrix of the context vectors, we derived entropy of equivalent Gaussian distribution, and based on the context vectors probability density function, we derived differential entropy. Negentropy was calculated as the difference between the two. Based on interpretation that entropy of equivalent Gaussian mirrors sense cooperation, or polysemy, while negentropy mirrors meaning competition, or homonymy, we predicted that in the set of strictly polysemous nouns, negentropy effect would disappear. In accordance with our predictions, entropy of equivalent Gaussian distribution accounted for significant proportion of processing latencies variance. Negentropy did not affect reaction time. This finding is in accordance with the hypothesis that entropy of equivalent Gaussian distribution, as a measure of general width of activation in semantic space, reflects polysemy, that is, the existence of related senses. Therefore, polysemy advantage could be the result of the wide-spread activation in semantic space and reduced competition among overlapping Gaussians.
Role of imiquimod as adjuvant for vaccination against Leishmania major infection in BALB/c mice

INTRODUCTION Leishmaniasis is caused by different species of the genus leishmania. This disease remains a major health problem in endemic countries with approximately 350 million people at risk of infection and the annual incidence of about 2 million. The available drugs for the treatment of the disease are toxic, require multiple doses, have limited efficacies, and their inappropriate use in some cases has led to emergence of drug resistance [1-3]. Over the past decade, co-infection of leishmaniasis and HIV has increasingly been reported; the HIV virus hastens the spread of Leishmania and can reawaken latent infections, while Leishmania accelerates AIDS onset [4, 5]. Presently, there are no proven vaccines against any form of leishmaniasis, and treatment options are severely limited [3, 6]. Regarding the fact that individuals who recover from leishmaniasis or lesions induced by leishmanization usually illicit long lasting protective immune responses, development of an effective anti-leishmania vaccine is theoretically feasible [1, 3, 7]. In spite of intensive efforts during the past decades, only a few first generation vaccines made from whole killed Leishmania parasits alone, or mixed with immunomodulators reached the phase 3 clinical trials. The results of efficacy trials on the first generation Leishmania vaccines showed limited efficacies and no improvement were achieved with booster injections. The main reason for this failure seems to be, in some part, due to lack of an appropriate adjuvant [1, 8].
Time-series Modelling, Stationarity and Bayesian Nonparametric Methods

In this paper we introduce two general non-parametric first-order stationary time-series models for which marginal (invariant) and transition distributions are expressed as infinite-dimensional mixtures. That feature makes them the first Bayesian stationary fully non-parametric models developed so far. We draw on the discussion of using stationary models in practice, as a motivation, and advocate the view that flexible (non-parametric) stationary models might be a source for reliable inferences and predictions. It will be noticed that our models adequately fit in the Bayesian inference framework due to a suitable representation theorem. A stationary scale-mixture model is developed as a particular case along with a computational strategy for posterior inference and predictions. The usefulness of that model is illustrated with the analysis of Euro/USD exchange rate log-returns.
Cargo Porphyry Cu-Au Deposit – Where is the High Grade Core?

The Cargo Copper-Gold Porphyry deposit lies within the world class porphyry belt of the Ordovician Macquarie volcanic arc. It is one of several porphyry complexes in the Lachlan Orogen including Cadia Valley (42.8 MOz Au), Northparkes, Cowal and Copper Hill. The Cargo Porphyry Intrusive Complex is a calc-alkaline suite of late Ordovician age (467 Ma) intrusives comprising quartz monzodiorite and diorite intruded by coeval andesitic and trachy-andesitic volcanics. The most prominent NW trending structural zone is characterised by areas of strong silicification, pyritisation and tectonic brecciation together with stockwork and sheeted quartz veining. It is up to 300 m wide bounded on the southern side by a major 60o SW dipping normal fault and on the Northern side by 75o SW dipping shear zones. Mineralization and alteration is zoned from a western core of fracture controlled, potassic altered porphyry (Cu-Mo-Au) to a peripheral zone of phyllic altered gold rich quartz-sulphide veining up to 200 m wide, surrounded by an outer propylitic zinc rich halo. The peripheral zone of Cargo contains gold rich sheeted quartz veins which hosted 14 small gold workings in the late 1800’s. Two lode systems, Dalcoath and Spur, have JORC inferred resource of 4 Mt @ 1.19g/t gold for 154,000 Oz Au. A classically zoned porphyry Cargo’s geochemical footprint is comparable in size to the famous Bingham Canyon and the Bougainville Panguna deposits despite the fact that Cargo’s porphyry deposits’ western half has been faulted away.
Camp War Buddies: Exploring the Therapeutic Benefits of Social Comparison in a Pediatric Oncology Camp

Cancer survival rates for youth have improved by 20%-30% in the past two decades, resulting in a greater need for therapeutic interventions that address the resulting psychosocial needs of patients post traditional medical treatment (Greenlee, Murray, Bolden, & Windgo, 2000). The purpose of this study was to measure the effect of attendance at a pediatric oncology camp designed to support the psychosocial needs of youth 8-18 years of age. Campers attending the oncology camp from Sunday through Friday were given a 12-item evaluation at the beginning of the week (pretest) and again at the end of the week (posttest) to gather quantitative data on independence, social skills, and self-esteem. A threemonth follow-up telephone interview was conducted to generate qualitative emerging themes. Findings suggest that campers had statistically significant improvements in self-esteem while emergent themes included a supportive community, normalizing experience, positive recollection of their camp experience and memories of specific activities. Social comparison theory is the foundation of the study and provides a framework for interpreting the results.
An Attempt to Image Chemical Ordering in Close-Packed Layer of Mg–Zn–Y 18R Long-Period Stacking-Ordered Structure by Scanning Tunneling Microscopy

For the first time, nanostructures of 18R (Mg85Zn6Y9) LPSO (long-period stacking-ordered) were examined using STM (scanning tunneling microscopy), which unambiguously confirmed the proposed model of the atomic structure of the LPSO phase in which the Zn­Y clusters are arranged in a two-dimensional hexagonal lattice in the (0001)hcp plane. The typical domain size of this hexagonal arrangement was estimated to range from several nanometers to a few tens of nanometers. In addition, the structures at the domain boundaries of the hexagonal arrangement were imaged and clarified by STM. [doi:10.2320/matertrans.M2013123]
The Ramachandran plot revisited from a new angle

The pioneering work of Ramachandran and colleagues emphasized the dominance of steric constraints in specifying the structure of polypeptides. The ubiquitous Ramachandran plot of backbone dihedral angles (φ and ψ) defined the allowed regions of conformational space. These predictions were subsequently confirmed in proteins of known structure. Ramachandran and colleagues also investigated the influence of the backbone angle τ on the distribution of allowed φ/ψ combinations. The ‘bridge region’ (φ ≤ 0◦ and −20◦ ≤ ψ ≤ 40◦) was predicted to be particularly sensitive to the value of τ . Here we present an analysis of the distribution of φ/ψ angles in 850 non-homologous proteins whose structures are known to a resolution of 1. 7Å or less and sidechain B-factor less than 30Å. We show that the distribution of φ/ψ angles for all 87,000 residues in these proteins shows the same dependence on τ as predicted by Ramachandran and colleagues. Our results are important because they make clear that steric constraints alone are sufficient to explain the dihedral angle distributions observed in proteins. Contrary to recent suggestions, no additional energetic contributions, such as hydrogen bonding, need be invoked.
Evaluating Leadership Training and Development: A Levels-of-Analysis Perspective

The changing context of work and organizations is calling upon new and differing demands of leadership. Differing contexts are also placing differing expectations on the goals of leadership training and development. To date, few comprehensive models to guide evaluation research and practice in the field of leadership training and development have appeared in the literature. This paper puts forward the first multi-level evaluation model to guide leadership training and development at five levels of analysis: Individual, Leader-Follower Dyad, Team, Organizational and Community. The model attempts to overcome significant limitations in previous evaluation models by putting forward clearer theoretical rationales to explain how leadership training and development impacts at each of these five levels. The model therefore is the first attempt to offer an integrative approach to examining how leadership may interact and bridge these differing levels of analysis. The model outlines the beginnings of a framework for identifying how specific behavioral and cognitive factors in organizations support social capital and the particular social and emotional skills and behaviors that facilitate social participation from which social capital can emerge.
Structural Design Feasibility Study for the Global Climate Experiment

Neon, Inc. is proposing to establish a Global Change Experiment (GCE) Facility to increase our understanding of how ecological systems differ in their vulnerability to changes in climate and other relevant global change drivers, as well as provide the mechanistic basis for forecasting ecological change in the future. The experimental design was initially envisioned to consist of two complementary components; (A) a multi-factor experiment manipulating CO{sub 2}, temperature and water availability and (B) a water balance experiment. As the design analysis and cost estimates progressed, it became clear that (1) the technical difficulties of obtaining tight temperature control and maintaining elevated atmospheric carbon dioxide levels within an enclosure were greater than had been expected and (2) the envisioned study would not fit into the expected budget envelope if this was done in a partially or completely enclosed structure. After discussions between NEON management, the GCE science team, and Keith Lewin, NEON, Inc. requested Keith Lewin to expand the scope of this design study to include open-field exposure systems. In order to develop the GCE design to the point where it can be presented within a proposal for funding, a feasibility study of climate manipulation structures must be conducted to determinemore » design approaches and rough cost estimates, and to identify advantages and disadvantages of these approaches including the associated experimental artifacts. NEON, Inc requested this design study in order to develop concepts for the climate manipulation structures to support the NEON Global Climate Experiment. This study summarizes the design concepts considered for constructing and operating the GCE Facility and their associated construction, maintenance and operations costs. Comparisons and comments about experimental artifacts, construction challenges and operational uncertainties are provided to assist in selecting the final facility design. The overall goal of this report is to provide a cost and technological basis for selection of the appropriate GCE Facility design. « less
Does the Mobility of R&D Labor Increase Innovation?

We investigate the effect of mobility of R&D workers on the total patenting activity of their employers. Our study documents how mobile workers affect the patenting activity of the firm they join and the firm they leave. The effect of labor mobility is strongest if workers join from patent-active firms. We also find evidence of a positive feedback effect on the former employer's patenting from workers who have left for another patent-active firm. Summing up the effects of joining and leaving workers, we show that labor mobility increases the total innovative activity of the new and the old employer. Our study which is based on the population of R&D active Danish firms observed between 1999 and 2004 thus provides firm-level support for the notion that labor mobility stimulates overall innovation of a country or region due to knowledge transfer.
The importance of microscopic examinations of eggshells : Discrimination of bioalteration and diagenetic overprints from biological features

Although fossilization usually favors the preservation of calcium carbonate biominerals, diagenetic alterations might still produce erratic patterns that overprint the original biological structures. This investigation tries to discriminate in the fossil record “pathological” eggshells from diagenetic induced features as well as determine their origin, and aims, when possible, to provide alternative parsimonious interpretations to the origin of some of these rare and erratic features. In the past, most dinosaur eggshell studies failed to combine cathodoluminescence, scanning electron microscopy, transmitted and polarized light microscopic observations and were limited to only one or several of these examinations, which might have contributed to misinterpretations by lack of thorough observations. Sauropod eggshells from Faidella (Spain) and Auca Mahuevo (Argentina) provide ideal proxies to perform this research, as they display aberrant crystallographic features that have been or could be considered pathological. Under cathodoluminescence, the specimens fluoresce tremendously, indicating a strong diagenetic component in their make up. Guided by this information, further transmitted and polarized light microscopic examinations reveal microscopic dissolution fronts, which otherwise would have been left unnoted. The proposed hypothesis for the Faidella specimens is that organic filaments, which represent up to 2% of the shell composition, were exposed on the internal wall surfaces of pore canals where the calcium carbonate had been dissolved during a ISSN (print): 1698-6180. ISSN (online): 1886-7995 www.ucm. es /info/estratig/journal.htm Journal of Iberian Geology 36 (2) 2010: 181-192 doi:10.5209/rev_JIGE. 2010.v36. n2.6 182 Grellet-Tinner et al. / Journal of Iberian Geology 36 (2) 2010: 181-192
A Pre-Assessment Questionnaire to Identify Healthcare Professionals’ Perception on Information Technology Implementation

 Abstract — Health information technologies promise higher quality, safer care and much more for both patients and professionals. Despite their promise, they are costly to develop and difficult to implement. On the other hand, user acceptance and usage determine the success of implemented information technology in healthcare. This study provides a model to understand health professionals’ perception and expectation of health information technology. Extensive literature review has been conducted to determine the main factors to be measured. A questionnaire has been designed as a measurement model and submitted to the personnel of an in vitro fertilization clinic. The respondents’ degree of agreement according to five-point Likert scale was 72% for convenient access to data and 69.4% for the importance of data security. There was a significant difference in acceptance of electronic data storage for female respondents. Also, other significant differences between professions were obtained.
Title Millimeter-wave UWB signal generation via frequency Up-conversion using fiber optical parametric amplifier

We propose and demonstrate a novel approach to generate millimeter-wave (MMW) ultra-wideband (UWB) signal via frequency up-conversion using fiber optical parametric amplifier (OPA). The baseband UWB signal is amplified by a high-repetition-rate pulsed pump and generates many sidebands separated by the modulation frequency of the pump. By selecting two or three of the sidebands and beating in the photodetector, we can obtain an up-converted signal in the MMW band. In our experiment, we have successfully demonstrated UWB signal up-conversion from 3 to 19 GHz with 18-dB optical gain using fiber OPA.
Distributed R&D, Cross-Regional Knowledge Integration and Quality of Innovative Output

We explore the impact of geographic dispersion of a firm's R&D activities on the quality of its innovative output. Using data on over half a million patents from 1,127 firms, we find that having geographically distributed R&D per se does not improve the quality of a firm's innovations. In fact, distributed R&D appears to be negatively associated with average value of innovations. This suggests that potential gains from access to diverse ideas and expertise from different locations probably gets offset by difficulty in achieving integration of knowledge across multiple locations. To investigate whether the innovating teams that do manage cross-fertilization of ideas from different locations achieve more valuable innovations, we analyze innovations for which there is evidence of such knowledge cross-fertilization along one of the followings dimensions: knowledge sourcing from remote R&D units, having at least one inventor with cross-regional ties, and having at least one inventor that has recently moved from another region. Analysis along these three dimensions consistently reveals a positive relationship between cross-regional knowledge integration and quality of resulting innovations. More generally, our findings provide new evidence regarding the importance of cross-unit integrative mechanisms for achieving superior performance in multi-unit firms.