Miracle-dz/UniFAR-FTUs huggingface dataset:
Research on the Division Method of Signal Control Sub-Region Based on Macroscopic Fundamental Diagram

The macroscopic fundamental diagram (MFD) provides a method to evaluate macro traffic operation through micro traffic parameters, which can be applied to traffic control to prevent traffic congestion transfer and improve road network efficiency. However, due to the large scale of the urban road network as well as the complex temporal and spatial distribution of road congestion, the application of the MFD for signal control first requires the partition of the urban road network. Based on the analysis of MFD partition purposes, a set of MFD partition methods based on graph theory was designed. Firstly, graph theory was used to transform the urban road network; secondly, the minimum spanning tree method was used to divide the urban traffic network map. Moreover, the attribution of the link between connected regions is determined. Our method can solve the problem of ambiguous intersection ownership, and the road sections belonging to the same road in opposite directions are separated. This method has the ability to control the size of the area by limiting the number of intersections; Finally, the evaluation index of regional clustering results was drawn. To achieve the research objective, we collected and processed vehicle information data from the Xuzhou car-hailing platform to obtain traffic density information. Then, we selected an area with sufficient data and a large enough road network. The empirical value range of the regional control value was obtained by comparing the values of multiple groups of measurement data k and evaluation indexes. In this process, it was found that during the period of flat peak and peak transition, while the regional average traffic density changes, the uniformity of traffic density first decreases and then increases. The traffic density uniformity of the signal control area can be improved by controlling the size of the signal control area. We obtained the empirical value range of the regional control value k by comparing the values of multiple groups of measurement data k and evaluation indexes. Then, we compared them with the two kinds of traditional partition algorithms and improved multiple dichotomy algorithms. Our method improves road network balance by 5% over existing methods.
The Role of Perioperative Levosimendan in Patients with Reduced Ejection Fraction undergoing Cardiac surgery in Reducing Post-operative Hemodynamic Support

BACKGROUND: Acute perioperative left ventricular dysfunction is a major complication affecting patients subjected to cardiac surgery and is associated with increased mortality. Levosimendan as a “calcium sensitizers” with inodilator effect improves myocardial contractility by sensitizing troponin C to calcium without increasing myocardial oxygen consumption and without impairing relaxation and diastolic function. AIM: The aim of this study was to evaluate the effect of perioperative levosimendan compared to the conventional management used in the patient with poor left ventricular function undergoing cardiac surgery to reduce the need of post-operative pharmacological and mechanical circulatory support. METHODS: It is prospective observational studies were patients undergoing cardiac surgery divided into two groups of 25 patients each. The first group received conventional management while the other group received levosimendan additionally duration and type of post-operative pharmacological support, duration of mechanical ventilation, durations of ICU and hospital stays, and major outcomes, and data about the need of mechanical support were collected. RESULTS: In the levosimendan, fewer patients required vasoactive agents post-surgery (Noradrenaline) compared to the conventional group, yet the use of inotropic support (adrenaline) in the 2nd day and the need of mechanical circulatory support was equal in both groups. The mortality was equal in both groups. CONCLUSION: Perioperative levosimendan may reduce the need of vasoactive agents postoperatively, but it does not reduce the need of inotropic nor mechanical support.
Endothelial S1pr2 regulates post-ischemic angiogenesis via AKT/eNOS signaling pathway

Aims: It is important to understand the mechanism that regulates post-ischemic angiogenesis and to explore a new therapeutic target for an effective improvement of revascularization in peripheral artery disease (PAD) patients. Post-ischemic angiogenesis is a highly orchestrated process, which involves vascular endothelial cells (ECs) proliferation, migration and assembly into capillaries. We found a significant reduction of S1pr2 (sphingosine 1-phosphate receptor 2) in endothelial cells after hindlimb ischemia (HLI). We thus hypothesized that EC-S1pr2 might be involved in the regulation of post-ischemic angiogenesis and blood flow recovery during peripheral arterial disease (PAD). Methods and Results: We generated both EC-specific S1pr2 loss-of-function and S1pr2 gain-of-function mice. Our study showed that EC-specific S1pr2 loss-of-function significantly enhanced post-ischemic angiogenesis and improved blood flow recovery upon femoral artery ligation, whereas the EC-specific S1pr2 gain-of-function severely hindered post-ischemic angiogenesis and reduced blood flow recovery in ischemic limbs. We next identified that S1pr2 inhibited AKT/eNOS signaling pathway, and thus inhibited EC proliferation/migration and angiogenic activity. As expected, pharmacological inhibition of S1pr2 by JTE013 improved post-ischemic angiogenesis and improved blood flow perfusion after femoral artery ligation. Moreover, we developed RGD-peptide magnetic nanoparticles packaging S1pr2-siRNA which specifically targeted ECs and achieved an efficient silencing of S1pr2 expression in ECs in vivo. This EC-targeted strategy to dampen S1pr2 significantly enhanced post-ischemic angiogenesis and boosted blood perfusion after HLI, supplying a novel therapy target for patients with peripheral arterial disease. Conclusions: This present study demonstrates that EC-expressing S1pr2 tightly controls post-ischemic angiogenesis and blood flow perfusion recovery. This research provides a novel strategy for EC-target knockdown of S1pr2 as a new therapeutic intervention for patients with peripheral artery disease.
The Influence of Corporate Culture upon Performance: A Quantitative Research

In a globalized, knowledge-based society with organizations that operate businesses around the globe, the corporate culture has become a key concept for multinational corporations that brings together individuals from different backgrounds, while trying to accomplish common objectives. The scope of this study is to see if there is a link between the corporate culture found in several multinational companies from Romania and the performance of the companies themselves. This study has been conducted by administering a Likert scale questionnaire to a diverse and representative sample, and then correlating the results using the Pearson coefficient. The results revealed without any doubt that there is a connection between the corporate culture that is found in the companies and the overall performance that the organizations are achieving.
Control of a variable speed and permanent magnet wind turbine: GARBI 150

This paper describes the revolutionary new wind turbine GARBI 150. The 150 kW permanent magnet synchronous generator and its full power converter with control in four quadrants make it interesting in medium scale wind power applications. The generator allows direct connection to the electrical distribution grid. The torque and pitch control have been designed to maximize energy capture and minimize fatigue loading of the turbine structure. These controllers are being validated with a first wind turbine prototype. A supervision system has also been implemented.
The Uniform Convergence of Multivariate Natural Splines

Let f be a function from R d to R that has square integrable q-th order partial derivatives, where q > d=2. Let be an arbitrary bounded set having a Pq? 1(R d)-unisolvent subset and consider a sequence fVk : k = 1; 2; 3; : : :g of sets in R d , each one containing a nite number of points that tend to \\ll up" as k ! 1. We prove that the sequence fsf;V k : k = 1; 2; 3; : : :g of the corresponding multivariate natural spline interpolants to f on Vk converges to f uniformly on as k ! 1. For d = q = 2, this result has been proved by Powell 16]. Here we extend his method of proof by estimating more general power functions. Related results on the uniform error of multivariate natural spline interpolation are also provided.
Surveys in combinatorics 1985: Combinatorics and Ramanujan's “Lost” Notebook

One end of a cable (12) is assembled to a connector (11) which is supported in a housing (10), and extends along a path through a cable entrance end (32) of the housing. The housing includes two mateable portions (25, 26) with one portion having a base (31) which includes a plurality of posts (50-50) projecting therefrom in a predetermined pattern between the connector and the cable entrance end to provide a plurality of cable paths through the housing. Each cross-sectional size cable within a range has an associated path with posts along the path engaging the cable to provide suitable strain relief therefor. Advantageously, the posts not only provide suitable strain relief for any cable within a range of cross-sectional sizes, but they also cooperate with openings (70-70) in the other portion of the housing to secure the two portions together.
An Integrative Transcriptomic Analysis Reveals EGFR Exon-19 E746-A750 Fragment Deletion Regulated miRNA, circRNA, mRNA and lncRNA Networks in Lung Carcinoma

Introduction Competing endogenous RNA (ceRNA) appears to be an important post-transcriptional manner that regulates gene expression through a miRNA-mediated mechanism. Mutations in exon-19 of EGFR were frequently observed in lung cancer genes, which were associated with EGFR activity and EGFR-targeted therapies. Methods We explored the transcriptome regulated by mutation in EGFR exon-19 E746-A750 fragment via using a network modeling strategy. We applied transcriptome sequencing to detect the deletion process of EGFR exon-19 E746-A750 fragment. Bio-informatics analyses were used to predict the gene target pairs and explain their potential roles in tumorigenesis and progression of lung cancer. Results We conducted an explorative lncRNA/miRNA/circRNA and mRNA expression study with two groups of lung adenocarcinoma tissues, including EGFR exon-19 E746-A750 deletion group and EGFR exon-19 wild-type group. Meanwhile, we screen out the hub genes related to the EGFR-19-D patient. Significant pathways and biological functions potentially regulated by the deregulated 128 non-coding genes were enriched. Conclusion Our work provides an important theoretical, experimental and clinical foundation for further research on more effective targets for the diagnosis, therapy and prognosis of lung cancer.
Building a safety program to protect the nanotechnology workforce : a guide for small to medium-sized enterprises

DISCLAIMER Mention of any company or product does not constitute endorsement by the National Institute for Occupational Safety and Health (NIOSH). In addition, citations to websites external to NIOSH do not constitute NIOSH endorsement of the sponsoring organizations or their programs or products. Furthermore, NIOSH is not responsible for the content of these websites. All Web addresses referenced in this document were accessible as of the publication date. NIOSH [2016]. Building a safety program to protect the nanotechnology workforce: a guide for small to medium-sized enterprises. iii FOREWORD The National Institute for Occupational Safety and Health (NIOSH) is pleased to present Building a Safety Program to Protect the Nanotechnology Workforce: A Guide for Small to Medium Sized Enterprises. Responsible development of nanotechnologies includes considering and managing the potential, unintended consequences to human health and the environment that might accompany development and use of the technology. This guide will demonstrate that the key to ensuring the safety of your business, particularly when resources are limited, is to prevent occupational exposures and incidents before they happen. Addressing safety and health issues in the workplace serves these important purposes:  Promotes and preserves employee well-being  Saves the employer money  Supports a competitive advantage  Adds value to the business  Engenders public trust. A strong, proactive safety program built and supported by the entire organization can also build confidence among your employees, investors, business associates, and insurance providers. This page intentionally left blank.
Do remittances affect labour participation decisions and hours worked? Evidence from Ethiopia

Abstract The present study examines the impact of remittances (foreign and domestic) on labour participation decisions and hours worked in Ethiopia. By exploiting nationally representative panel data obtained from the Ethiopian Socio-Economic Survey (ESS) 2013/14 and 2015/16, this study finds that receiving foreign remittances has a negative impact on the adult labour participation decisions and hours worked in Ethiopia. Its effect is also conditional on occupation, gender, and residential location. However, the impact of domestic remittances on the decision to participate in the non-domestic labour activity is mixed by residential location. Labour participation decisions for rural adults has increased but decreased for the urban. Its effect on the labour participation decisions in temporary paid jobs is also positive. On the other hand, this study finds that child labour participation decisions and hours worked are neither affected by the amount of foreign and domestic remittances nor by remittance-receiving status. The econometric technique applied logit and Tobit models, and a robustness check has been carried out using the per adult equivalent amount of remittances. This study suggested that further studies to identify causes for the negative effects on labour participation decisions and hours worked are critical to designing an appropriate policy. However, since it increases adult labour participation in rural areas and participation in temporary paid jobs, enabling policies to increase domestic remittances are highly important.
Association Between Sleep Microstructure and Incident Hypertension in a Population‐Based Sample: The HypnoLaus Study

Background Poor sleep quality is associated with increased incident hypertension. However, few studies have investigated the impact of objective sleep structure parameters on hypertension. This study investigated the association between sleep macrostructural and microstructural parameters and incident hypertension in a middle‐ to older‐aged sample. Methods and Results Participants from the HypnoLaus population‐based cohort without hypertension at baseline were included. Participants had at‐home polysomnography at baseline, allowing assessment of sleep macrostructure (nonrapid eye movement sleep stages 1, 2, and 3; rapid eye movement sleep stages; and total sleep time) and microstructure including power spectral density of electroencephalogram in nonrapid eye movement sleep and spindles characteristics (density, duration, frequency, amplitude) in nonrapid eye movement sleep stage 2. Associations between sleep macrostructure and microstructure parameters at baseline and incident clinical hypertension over a mean follow‐up of 5.2 years were assessed with multiple‐adjusted logistic regression. A total of 1172 participants (42% men; age 55±10 years) were included. Of these, 198 (17%) developed hypertension. After adjustment for confounders, no sleep macrostructure features were associated with incident hypertension. However, low absolute delta and sigma power were significantly associated with incident hypertension where participants in the lowest quartile of delta and sigma had a 1.69‐fold (95% CI, 1.00–2.89) and 1.72‐fold (95% CI, 1.05–2.82) increased risk of incident hypertension, respectively, versus those in the highest quartile. Lower spindle density (odds ratio, 0.87; 95% CI, 0.76–0.99) and amplitude (odds ratio, 0.98; 95% CI, 0.95–1.00) were also associated with higher incident hypertension. Conclusions Sleep microstructure is associated with incident hypertension. Slow‐wave activity and sleep spindles, 2 hallmarks of objective sleep continuity and quality, were inversely and consistently associated with incident hypertension. This supports the protective role of sleep continuity in the development of hypertension.
American Civil–Military Relations and Presidential Power of Removal

Under what conditions are presidents more likely to remove senior defense officials from office? Using a novel data set of all senior U.S. defense officials, both civilian and uniformed military from 1947 to 2021, this article explores whether anticipated support in Congress, partisan factors, or institutional protections for the military affect observed patterns of removal for defense officials. The results suggest that presidents are more likely to remove their own appointees (or their co-partisans’ appointees), but provide little evidence that presidents premise removal on anticipated partisan support for a replacement nominee in Congress. Moreover, the results suggest that military officials may have some insulation from politicization by strong forms of removal, though that protection may weaken an important aspect of civilian control of the military, the threat of punishment by removal, raising profound questions for how civilian control endures.
Influence of Harvest Time on the Chemical Profile of Pereskia aculeate Mill. Using Paper Spray Mass Spectrometry

This study evaluated the physicochemical characteristics and the production of bioactive compounds of Pereskia aculeata Mill. at different harvest times. Here, we performed a qualitative evaluation of the chemical profile by paper spray mass spectrometry (PSMS), the phenolic acid and flavonoid profile by high-performance liquid chromatography (HPLC), antioxidant activity, total carotenoids, total phenolic compounds, total flavonoids, total anthocyanins, color characteristics, total soluble solids (TSS), total solids (TS), pH, and total titratable acidity (TTA). The chemical profile was not affected, with the exception of 4,5-dimethyl-2,6-octadiene and azelaic acid, which was only identified in the leaves harvested during the winter. The content of four phenolic acids and three flavonoids were analyzed; out of these, no significant amounts of ellagic acid and quercetin were detected. There was no difference in production of bioactive compounds between seasons, reflecting the antioxidant activity, which also did not differ. Brightness, chroma, and leaf pH were the only physicochemical characteristics that did not vary between seasons.
Silk fibroin-based biomaterials for cartilage/osteochondral repair

Osteoarthritis (OA) is a common joint disease with a high disability rate. In addition, OA not only causes great physiological and psychological harm to patients, but also puts great pressure on the social healthcare system. Pathologically, the disintegration of cartilage and the lesions of subchondral bone are related to OA. Currently, tissue engineering, which is expected to overcome the defects of existing treatment methods, had a lot of research in the field of cartilage/osteochondral repair. Silk fibroin (SF), as a natural macromolecular material with good biocompatibility, unique mechanical properties, excellent processability and degradability, holds great potential in the field of tissue engineering. Nowadays, SF had been prepared into various materials to adapt to the demands of cartilage/osteochondral repair. SF-based biomaterials can also be functionally modified to enhance repair performance further. In this review, the preparation methods, types, structures, mechanical properties, and functional modifications of SF-based biomaterials used for cartilage/osteochondral repair are summarized and discussed. We hope that this review will provide a reference for the design and development of SF-based biomaterials in cartilage/osteochondral repair field.
Proteomics reveals differential adsorption of angiogenic platelet lysate proteins on calcium phosphate bone substitute materials

Abstract Protein adsorption on biomaterials for bone substitution, such as calcium phosphates (CaP), evokes biological responses and shapes the interactions of biomaterials with the surrounding biological environment. Proteins adsorb when CaP materials are combined with growth factor-rich hemoderivatives prior to implantation to achieve enhanced angiogenesis and stimulate new bone formation. However, the identification of the adsorbed proteins and their angiogenic effect on bone homeostasis remain incompletely investigated. In this study, we analyzed the adsorbed complex protein composition on CaP surfaces when using the hemoderivatives plasma, platelet lysate in plasma (PL), and washed platelet lysate proteins (wPL). We detected highly abundant, non-regenerative proteins and anti-angiogenic proteins adsorbed on CaP surfaces after incubation with PL and wPL by liquid chromatography and mass spectrometry (LC–MS) proteomics. Additionally, we measured a decreased amount of adsorbed pro-angiogenic growth factors. Tube formation assays with human umbilical endothelial cells demonstrated that the CaP surfaces only stimulate an angiogenic response when kept in the hemoderivative medium but not after washing with PBS. Our results highlight the necessity to correlate biomaterial surfaces with complex adsorbed protein compositions to tailor the biomaterial surface toward an enrichment of pro-angiogenic factors.
Design and investigation of stability‐ and power‐improved 11T SRAM cell for low‐power devices

The modern system‐on‐chips require stable and low‐power SRAM cells due to technology scaling and limited sources of energy. Therefore, a stability‐ and power‐improved 11T SRAM cell is proposed in this study. The proposed cell core is composed of a strong cross‐coupled structure of a conventional inverter with a N‐type stacked transistor and a Schmitt‐trigger (ST) with a double channel‐length pull‐up network. This coupled with a separate read path enhances the read static noise margin (RSNM). Moreover, a feedback‐cutting N‐type transistor is placed inside the cell core to improve the write static noise margin (WSNM)/write margin (WM). Though the presence of stacked transistors in access paths increases read delay (TRA)/write delay (TWA), it reduces leakage. This metric further minimizes with the aid of a stacked structure of latch core and double channel‐length of pull‐up transistor in the ST inverter. The moderate read/write frequency and single‐ended structure of the suggested cell result in low dynamic power. Simulated results by using 16‐nm CMOS at VDD = 0.7 V show that the proposed cell has the second‐best RSNM/WSNM, which is 4.65/1.44 times higher than that of the fully differential 8T (FD8T) cell, as the basic cell. Moreover, it reduces leakage power by at least 2.01 times and consumes moderate read/write power, nearly 1.44/1.81 times lower than that of FD8T cell, at the cost of 1.61 times area overhead. The proposed cell can eliminate read/write‐half‐select‐disturbance issues to support bit‐interleaving architecture to increase soft error immunity.
Increased landscape disturbance and streamflow variability threaten fish biodiversity in the Red River catchment, USA

Stream fish distributions are hypothesized to be strongly associated with landscape characteristics at multiple scales. Variation in flow regimes and intensity of landscape disturbance are associated with stream fish distributions; however, relationships are poorly understood in many high‐diversity regions. Our objective was to identify occurrence relationships between fish distributions and streamflow and landscape characteristics in the south‐central United States.