Miracle-dz/UniFAR-FTUs huggingface dataset:
Leadership for Health Professionals

The characteristics of health systems and organizations are unique and that warrant a tailored approach. The leadership and managerial role of a health professional is more important in today's world of globalization, digital technology, advancement in communication, health being demanded as human right and warranted practice based on evidences. The good thing about leadership is that it can be learned. Many in-service courses have been introduced in some programs and are being offered by many institutions. We need a government led comprehensive approach to strengthen these skills essentially by doing three things. Leadership development is not done solely to improve the leadership skills of one individual but is an essential component of the development of the organization as a whole. Progressive health systems that invest in leadership development for the entire senior management team will have the more significant return on investment in terms of organizational effectiveness.
Nurses’ Knowledge About Palliative Care: A Cross-Sectional Survey

Insufficient knowledge of palliative care among nurses is well documented and is considered one of the main obstacles to providing high-quality palliative care services. Thus, this study aims to evaluate Jordanian registered nurses’ knowledge about palliative care. A quantitative research method and a descriptive cross-sectional survey design were used. The sample consisted of 190 registered nurses working in 5 Jordanian government hospitals. Most participants were male (54%) and younger than 30 years (59%). They were working in surgical (32%), medical (28%), and critical care (22%) units. The total mean score of palliative knowledge was low at 8.3 (SD, 2.8), ranging from 0 to 15. The findings of the study demonstrate that nurses have insufficient knowledge about the essence, philosophy, and principles of palliative care. This study shows that nurses have insufficient knowledge and misconceptions about palliative care. Hence, basic education is needed for all nurses working in government hospitals. This education needs to be comprehensive to cover the basic principles of palliative care and symptom management. In addition, it should address the misconceptions identified in this study.
Healthy Hydration for Physical Activity

Water is the first ingredient of life. In the comfortable environment in which we live, with an ample supply of water, we forget that our ancestors lived in an environment where water was scarce, and the weather was hot. We therefore developed a very powerful cooling system in which water plays a major role. The importance of this system is best illustrated when we are exposed to exercise and heat, separately and even more when both are combined. In these situations, the primary way to get rid of the heat generated or received from the environment is through the secretion and evaporation of sweat, which is mainly water. Thanks to this cooling system, we can sustain prolonged exposures to heat and we can work in the heat. However, if not properly replaced, fluid loss under the form of sweat results in dehydration. This reduces the ability to regulate body temperature as well as the ability to perform exercise. Under extreme circumstances, which fortunately are not often encountered, dehydration and the increase in body temperature can result in heat stroke, which could be fatal
Adolescent and Young Adult Palliative Care at the UFHealth Streetlight Program: Impacts on Pre-medical and Pre-healthcare Professionals

Clinical and research literature in medical education indicates a dearth of opportunities to adequately and competently prepare young pre-medical and pre-healthcare professionals to attend to the needs of dying patients, especially youths and their families. This study aimed to explore outcomes of an innovative palliative care program on 142 past and present pre-medical and pre-healthcare student volunteers. Results of the mixed-methods study indicate that the Streetlight program significantly impacted these student volunteers’ sense of empathy, compassion, and comfort in attending to dying adolescents and young adults. Qualitative themes included the following: leadership vision, investment among members, member characteristics, relationship with self, learning about others, learning about professions, learning about the healthcare system, spirituality, appreciation for life, and emotional connections. Given the apparent lessons reported by the past and present student members who participated in the study, the Streetlight program may be a viable model for introducing pre-medical and pre-healthcare students to compassionate palliative care.
Effects of Acanthopanax Senticosus Injection on Learning and Memory Impairment and Monoamine Neurotransmitter of Hippocampus in Aging Model Rats

Objective To study the effects of Acanthopanax Senticosus Injection(ASI) on learning and memory impairment and monoamine neurotransmitter(ACh,NE and 5-HT) of hippocampus homogenate in aging model rats.Metholds Total of 60 male Wister rats were randomized into 6 groups: control group,sham operation group,model group and treatment group,the latter was randomized into low,middle and high dose groups.All group anesthetized by chloral hydrate.After stereotaxis,the ageing models were build by injecting QA(dissolved into PBS) 2 μL into CAI district of double sides of hippocampus in those control group,model group and treatment group,the sham operation group were injected the same volume of PBS.One week after operation,NS,ASI or huperzine A was given(ig) to rats for 30d.The sham operation and model groups were given NS(2 mL). The treatment groups were given ASI(50,100,200 mg/kg). The control group were given Huperzine-A(0.3 mg/kg). The ability was tested by Morris water maze on learning,memory and space exploration in rats.ACh,NE and 5-HT were measured in hippocampus homogenate.Results The incubation period of seeking platform was decurtated and the errors was reduced in aging model rats by ASI;The treatment groups of ACh,NE and 5-HT of hippocampus homogenate were higher than model group,but lower than sham operation group(P0.05 or P0.01),strengthening effects with increasing dosage.Conclusion ASI can obviously improve learning and memory,the mechanism of action mechanism correlates to the mobilization of the monoamine neurotransmitter(ACh,NE and 5-HT) in hippocampus.
Adoção de Tecnologia da Informação pelas Micro e Pequenas Empresas do Setor Hoteleiro de Sergipe

Tourism big companies make extensive use of Information Technology (IT), also named Information and Communication Technology (ICT), to promote their products or services and this trend has also been incorporated by Small and Medium Enterprises (SME) from the hospitality sector. This study intend to increase the understanding of this phenomenon in order to analyze IT adoption by SME businesses of hospitality industry examined exclusively in the state of Sergipe. It was used a qualitative approach with a multiple case study strategy. It has been found that all hospitality enterprises analyzed own computers and they are all connected to Internet. It has also been found that IT failure has a high impact. Different managers’ profiles had been identified and it was observed that staff’s IT knowledge is considered indispensable. Limitations of this research are directly connected to the limits of multiple case study strategy.
Homelessness in Calgary From the Perspectives of Those Experiencing Homelessness

Homelessness in Calgary From the Perspectives of Those Experiencing Homelessness by Edith N. Ahajumobi MPH, Walden University, 2013 MBA, ESUT Nigeria, 2003 PGD, ESUT Nigeria, 2001 B.Sc, Food Science & Tech, Ebony State University, Nigeria, 1992 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Public Health Walden University September 2017
Strength of reinforced concrete bridge decks under compressive membrane action

Compressive membrane action exists in the slabs of typical reinforced concrete beam-and-slab bridge decks, significantly increasing the slab's stiffness and strength in both flexure and punching shear. Approximate methods to account for compressive membrane action have been developed by previous researchers. However, compressive membrane action is usually not taken into account when determining the strength of reinforced concrete slabs, because it is difficult to measure the restraint stiffness that exists for the slab. This article presents a design method for assessing the restraint stiffness that exists for the slab of typical beam-and-slab bridge decks and the strength enhancement due to compressive membrane action. The results offer a more accurate prediction of the strength of the slab. The method has been developed through the laboratory testing of concrete specimens and the use of nonlinear finite element modeling. The authors conclude that a significant amount of compressive membrane action can be expected to develop transversely in the slabs of actual beam-and-slab bridge decks. The stiffness and strength of the slabs can then be expected to be significantly higher than that predicted using methods that do not incorporate the enhancing effects of compressive membrane action.
Individual and community level determinants of short birth interval in Ethiopia: A multilevel analysis

Background The World Health Organization recommends a minimum of 33 months between two consecutive live births to reduce the risk of adverse maternal and child health outcomes. However, determinants of short birth interval have not been well understood in Ethiopia. Objective The aim of this study was to assess individual- and community-level determinants of short birth interval among women in Ethiopia. Methods A detailed analysis of the 2016 Ethiopian Demographic and Health Survey data was performed. A total of 8,448 women were included in the analysis. A two-level multilevel logistic regression analysis was used to identify associated individual- and community-level factors and estimate between-community variance. Results At the individual-level, women aged between 20 and 24 years at first marriage (AOR = 1.37; 95% CI: 1.18–1.60), women aged between 25 and 29 years at first marriage (AOR = 1.65; 95% CI: 1.20–2.25), having a husband who attended higher education (AOR = 1.32; 95% CI: 1.01–1.73), being unemployed (AOR = 1.16; 95% CI: 1.03–1.31), having an unemployed husband (AOR = 1.23; 95% CI: 1.04–1.45), being in the poorest wealth quintile (AOR = 1.82; 95% CI: 1.39–2.39), being in the poorer wealth quintile (AOR = 1.58; 95% CI: 1.21–2.06), being in the middle wealth quintile (AOR = 1.61; 95% CI: 1.24–2.10), being in the richer wealth quintile (AOR = 1.54; 95% CI: 1.19–2.00), increased total number of children born before the index child (AOR = 1.07; 95% CI: 1.03–1.10) and death of the preceding child (AOR = 1.97; 95% CI: 1.59–2.45) were associated with increased odds of short birth interval. At the community-level, living in a pastoralist region (AOR = 2.01; 95% CI: 1.68–2.39), being a city dweller (AOR = 1.75; 95% CI: 1.38–2.22), high community-level female illiteracy (AOR = 1.23; 95% CI: 1.05–1.45) and increased distance to health facilities (AOR = 1.32; 95% CI: 1.11–1.56) were associated with higher odds of experiencing short birth interval. Random effects showed significant variation in short birth interval between communities. Conclusion Determinants of short birth interval are varied and complex. Multifaceted intervention approaches supported by policy initiatives are required to prevent short birth interval.
Strenuous Acute Exercise Induces Slow and Fast Twitch-Dependent NADPH Oxidase Expression in Rat Skeletal Muscle

The enzymatic complex Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase (NOx) may be the principal source of reactive oxygen species (ROS). The NOX2 and NOX4 isoforms are tissue-dependent and are differentially expressed in slow-twitch fibers (type I fibers) and fast-twitch fibers (type II fibers) of skeletal muscle, making them different markers of ROS metabolism induced by physical exercise. The aim of this study was to investigate NOx signaling, as a non-adaptive and non-cumulative response, in the predominant fiber types of rat skeletal muscles 24 h after one strenuous treadmill exercise session. The levels of mRNA, reduced glycogen, thiol content, NOx, superoxide dismutase, catalase, glutathione peroxidase activity, and PPARGC1α and SLC2A4 gene expression were measured in the white gastrocnemius (WG) portion, the red gastrocnemius (RG) portion, and the soleus muscle (SOL). NOx activity showed higher values in the SOL muscle compared to the RG and WG portions. The same was true of the NOX2 and NOX4 mRNA levels, antioxidant enzymatic activities, glycogen content. Twenty-four hours after the strenuous exercise session, NOx expression increased in slow-twitch oxidative fibers. The acute strenuous exercise condition showed an attenuation of oxidative stress and an upregulation of antioxidant activity through PPARGC1α gene activity, antioxidant defense adaptations, and differential gene expression according to the predominant fiber type. The most prominent location of detoxification (indicated by NOX4 activation) in the slow-twitch oxidative SOL muscle was the mitochondria, while the fast-twitch oxidative RG portion showed a more cytosolic location. Glycolytic metabolism in the WG portion suggested possible NOX2/NOX4 non-regulation, indicating other possible ROS regulation pathways.
Phytogenic Generation of NiO Nanoparticles Using Stevia Leaf Extract and Evaluation of Their In-Vitro Antioxidant and Antimicrobial Properties

In the present study, economically viable NiO nanoparticles were produced by biogenic preparation using stevia leaf broth and their in-vitro antioxidant and antimicrobial activities were evaluated. The properties of the prepared NiO nanoparticles were confirmed by analytical techniques such as Ultraviolet-Visible (UV-Vis), X-ray diffraction (XRD), FE-SEM, and Fourier transform infrared spectroscopy (FTIR) analyses. Morphological studies using scanning electron microscopy (SEM) and transmission electron microscopy (TEM) showed that the size of synthesized nanoparticles ranged from 20 to 50 nm, most of which were spherical and few of which were agglomerated. The role of the biological moieties, which reduce and cap the nanoparticles, was studied using FTIR analysis. The prepared nanoparticles strongly inhibited gram-negative bacteria, which is a camper with gram-positive bacteria and fungi. Furthermore, it performs an effective in-vitro activity through α,α-diphenyl-β-picrylhydrazyl (DPPH) reduction. Thus, it can be concluded that the effective and easy green synthesis process used for NiO nanoparticles provides potential antimicrobial agents against multidrug-resistant microbes.
IL10 rs1800872 Is Associated with Non-Steroidal Anti-Inflammatory Drugs Exacerbated Respiratory Disease in Mexican-Mestizo Patients

Non-steroidal anti-inflammatory drugs (NSAID) exacerbated respiratory disease (N-ERD) is a disease integrated by asthma, nasal polyps, and hypersensitivity to non-steroidal anti-inflammatory drugs (NSAID). Genetic association studies have explored single nucleotide polymorphisms (SNPs) in genes involved in theoretical pathophysiological mechanisms, but most of these lack replication of findings in second populations. Our objective was to evaluate the association of SNPs in candidate genomic regions described in Asian and European subjects with N-ERD in Mexican-mestizo patients. We designed a replicative study in two stages. We included 381 SNPs selected by fine mapping of associated genes in a microarray, which were tested in three groups: N-ERD (N), asthma (A), and control group (CG); by means of GoldenGate array, positive results by genetic models were validated in the second stage in another population through qPCR with the same methodology. In the allelic model, we identified 11 SNPs in N vs. CG comparison, and five in N vs. A and A vs. CG, respectively. By genetics models, all SNPs in PPARG, rs13239058 in TBXAS1, and rs1554286 and rs1800872 in IL10 were associated in both models. In the second stage, only rs1800872CC showed an association in the dominant model comparing N vs. GC, p = 0.004, OR = 0.44. In conclusion, rs1800872 in IL10 was the only associated with N-ERD in Mexican-mestizo patients.
Differential expression of olfactory genes in Atlantic salmon (Salmo salar) during the parr–smolt transformation

Abstract The anadromous salmon life cycle includes two migratory events, downstream smolt migration and adult homing migration, during which they must navigate with high precision. During homing migration, olfactory cues are used for navigation in coastal and freshwater areas, and studies have suggested that the parr–smolt transformation has a sensitive period for imprinting. Accordingly, we hypothesized that there would be significant changes in gene expression in the olfactory epithelium specifically related to smoltification and sampled olfactory rosettes from hatchery‐reared upper growth modal juvenile Atlantic salmon at 3‐week intervals from January to June, using lower growth modal nonsmolting siblings as controls. A suite of olfactory receptors and receptor‐specific proteins involved in functional aspects of olfaction and peripheral odor memorization was analyzed by qPCR. Gene expression in juveniles was compared with mature adult salmon of the same genetic strain caught in the river Gudenaa. All mRNAs displayed significant variation over time in both modal groups. Furthermore, five receptor genes (olfc13.1, olfc15.1, sorb, ora2, and asor1) and four olfactory‐specific genes (soig, ependymin, gst, and omp2) were differentially regulated between modal groups, suggesting altered olfactory function during smoltification. Several genes were differentially regulated in mature salmon compared with juveniles, suggesting that homing and odor recollection involve a different set of genes than during imprinting. Thyroid hormone receptors thrα and thrβ mRNAs were elevated during smolting, suggesting increased sensitivity to thyroid hormones. Treatment of presmolts with triiodothyronine in vivo and ex vivo had, however, only subtle effects on the investigated olfactory targets, questioning the hypothesis that thyroid hormones directly regulate gene expression in the olfactory epithelium.
Five-year results of the BEGEV salvage regimen in relapsed/refractory classical Hodgkin lymphoma.

The complete remission (CR) rate achieved with induction chemotherapy prior to autologous stem cell transplantation (ASCT) represents the strongest prognostic factor in relapsed/refractory (R/R) classical Hodgkin lymphoma (cHL). By inducing a CR rate of 75%, the bendamustine, gemcitabine, vinorelbine (BEGEV) regimen represents an optimal chemotherapy regimen prior to ASCT. Presented here are the 5-year results of BEGEV followed by ASCT in R/R cHL. With a median follow-up of 5 years, progression-free survival (PFS) and overall survival (OS) for the whole series (n = 59) were 59% and 78%, respectively. ASCT was performed in 43 of 49 responding patients (73% by intention to treat [ITT]; 88% by response to BEGEV) and resulted in 33 with continuous CR (56% by ITT; 77% of transplanted patients), 7 with disease relapse, and 3 with nonrelapse mortality. For patients who received transplants, the 5-year PFS and OS were 77% and 91%, respectively, with no significant difference between relapsed and refractory patients. No patient experienced secondary leukemia or myelodysplasia. In summary, the long-term efficacy data, the benefits for both relapsed and refractory patients, and the excellent safety profile provide a strong rationale for further development of the BEGEV regimen. This trial was registered at EudraCT as #2010-022169-91 and at www.clinicaltrials. gov as #NCT01884441.
Screening and Identification of the Main Metabolites of Schisantherin a In Vivo and In Vitro by Using UHPLC-Q-TOF-MS/MS

Schisantherin A is an active ingredient originating from Schisandra chinensis (Turcz.) which has hepatoprotective and anti-oxidation activities. In this study, in vitro metabolisms investigated on rat liver microsomes (RLMs) and in vivo metabolisms explored on male Sprague Dawley rats of Schisantherin A were tested, respectively. The metabolites of Schisantherin A were identified using ultra-high-performance liquid chromatography coupled with hybrid triple quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS). Based on the method, 60 metabolites were successfully identified and structurally characterized including 48 phase-I and 12 phase-II metabolites. Among the metabolites, 45 metabolites were reported for the first time. Moreover, 56 and eight metabolites were detected in urine and bile and 19 metabolites were identified in rats’ plasma. It demonstrated that hepatic and extra-hepatic metabolic pathways were both involved in Schisantherin A biotransformation in rats. Five in vitro metabolites were structurally characterized for the first time. The results indicated that the metabolic pathways mainly include oxidation, reduction, methylation, and conjugation with glucuronide, taurine, glucose, and glutathione groups. This study provides a practical strategy for rapidly screening and identifying metabolites, and the results provide basic data for future pharmacological and toxicology studies of Schisantherin A and other lignin ingredients.
Preliminary Guidelines for Reporting Treatment Results in Meniere's Disease

In order to draft guidelines for reporting treatment results in Japan, the 17 Committee Members elected from the Japan Society for Equilibrium Research have held discussion for about two years. Preliminary guidelines are summarized here.1) Evaluation of Symptoms: Only definite vertiginous spells with spontaneous nystagmus should be considered for evaluation (AAOO 1972). Hearing levels assessed from the four-frequencies pure-tone average (PTA) at 250 Hz, 500 Hz, 1 KHz, 2 KHz in Meniere's disease.2) Evaluation Period: Valid results of the evaluation should be based on evaluation for over six months in pre-treatment and for more than twelve months in post-treatment after initiation of the therapy.3) Evaluation Criteria: The formula expressing the effects of treatment on vertiginous spells should be the same as the AAOHNS (1985) criteria. If the duration of pre-treatment is less than six months, the divisor is the average number of definite spells per month during the period of observation.4) Global Judgment: Patients and doctors should evaluate on their treatment results from the standpoints of their subjective symptoms and objective signs, respectively.