Miracle-dz/UniFAR-FTUs huggingface dataset:
Refining Cancer Management Using Integrated Liquid Biopsy

Liquid biopsy has emerged in the last ten years as an appealing noninvasive strategy to support early cancer diagnosis and follow-up interventions. However, conventional liquid biopsy strategies involving specified biomarkers have encountered unexpected inconsistencies stemming from the use of different analytical methodologies. Recent reports have repeatedly demonstrated that integrated detection of multiple liquid biopsy biomarkers can significantly improve diagnostic performance by eliminating the influence of intratumoral heterogeneity. Herein, we review the progress in the field of liquid biopsy and propose a novel integrated liquid biopsy framework consisting of three categories: elementary, intermediate, and advanced integration. We also summarize the merits of the integration strategy and propose a roadmap toward refining cancer diagnosis, metastasis surveillance, and prognostication.
Collaborative action research to reduce patient wait times: Results in two high-demand public clinics in Western Cape, South Africa

Introduction: Lengthy waiting times are problematic for patients and healthcare workers alike. In clinics and hospitals across Africa, persistently long wait times have been linked to poor medication compliance, skipped appointments, delayed implementation of clinical programs, and low healthcare worker morale. This paper presents results from collaborative action research projects at two high-demand primary care public health facilities in Cape Town, South Africa. Projects were built around two-week focal interventions undertaken by clinic staff and US-based graduate students in concert with clinic leadership, researchers, and faculty. Collaborators aimed to generate practical local solutions to improve within-facility wait times. Methods: Drawing on detailed time stamp data for over 2,400 patient visits, we compared entry-to-exit times before and after focused action research collaborations and examined operational changes along with sitespecific enabling and constraining factors. Findings: Mean wait times were significantly reduced, from 129 to 102 minutes in one clinic’s pharmacy and from 275 to 196 minutes in the second clinic. Operational changes sustained over three months after the focal collaboration took the form of procedural improvements, technology adjustments, tailoring of patient visits, and team capacity-building. Contextual barriers included staff turnover, varying staff participation, mandated software changes, and resource constraints, while enablers included leadership commitment, experience with past improvement collaborations, and advocacy. Conclusions: Amid the complexity of operating a busy primary care facility and an array of structural and relational factors, the action research collaboration demonstrated that simple changes generated in situ can help address the vexing challenge of persistent lengthy wait times. Further research is needed to assess ongoing sustainability and broader applicability, but results underscore the potential value in enabling facilities to collect and analyze operational data. Our findings reveal the promise of short term, inclusive action research Manuscript ic r t n a Manuscript astr t a ait ti r su ts su issi n c
Neurotransmitter Changes of Urine in the Patient of Premenstrual Syndrome with Invasion of the Hyperactive Liver-qi with Jingqianping Granule Treatment

Objective:To probe into curative effect in the patient of premenstrual syndrome(PMS) with invasion of the hyperactive Liver-qi with Jingqianping granule treatment and reveal partial microcosmic mechanisms of invasion of the hyperactive Liver-qi.Methods:Method of fluorescence was used to determine content of changes of catecholamine(CA),adrenalin(Ad),noradrenalin(NA) in 24h urine in the patients before and after treatment.Results:The gross CA increased significantly,Ad decreased,increased greatly in the patients before therapy,CA,Ad,NA were improved or approached natural level.Conclusion:Curative effect is significantly in the patients with Jingqianping granule treatment,CA and NA increased,Ad decreased is possibly one of the micro-mechanism or PMS with invasion of the hyperactive Liver-qi.
Quantifying Product Creativity in Design: A Quasi-Experimental Methodological Approach

Creativity research studies have been predominately focused on adopting methodologies rooted in psychology. Employing various psychometric approaches, experts use sophisticated statistical tools to understand the multifaceted aspects of creativity (Long, 2004). Quantitative methodologies dominate the field of research, specifically creativity metrics which seem to be contingent on psychometric enquirers that primarily test creative thinking. Experts now imply that disagreement on some of the key issues of creativity assessment and measurement could indicate a lack of methodological diversity (Hove 2004). As such, this study proposes an adapted quasi-experimental approach. A game-like task (CBoard©) was developed in order to generate products in an attempt to quantify a creativity dimension: flexibility. The step-bystep model proposed here is a methodological approach that could be applied to the study of creativity in domains that exist outside psychology.
Lighthouse: focused search of entities and relations on the Web

Background: Digital data is produced and shared at break-neck speed today – whether as text (news articles), as semi-structured data (tweets, other social media content) or as structured data (RDF or CSV files). Real-world events such as elections, public demonstrations, disclosures of illegal or surprising activities, etc. are mirrored in new data items being created and added to the global corpus of available information. Making sense of this wealth of data and being able to use them in an integrated fashion is a highly prized goal. In collaboration with Le Monde, the team Cedar has collected public data about French politicians and has organized this information as a heterogeneous graph, where nodes represent entities, i.e. person, location or organization, and edges represent connections between these entities. Such connections can be explored using keyword search. Specifically, given a set of k ≥ 2 search terms such as, e.g., “Assemblée Nationale” and “Russia”, we can find all the paths that lead from a node matching the former term to another that matches the second term. This enables finding that “Assemblée Nationale” and “Russia” are connected through the contract that the wife of a member of the Assemblée has with a Russian state-owned company [1].
Cellular Structure for a Digital Fiat Currency

Bitcoin introduced digital money without banks. It showed that functions of the financial system could be reliably executed by decentralized networks and in doing so raised the prospect of a new financial system. Almost a decade later, Bitcoin still works despite frequent predictions of its demise but the overwhelming majority of payments still use fiat currencies and the financial system is unchanged. We propose a cellular structure in which digital fiat currency issuers and transaction validators create functionally separate ledgers, decentralized but capable of cohering into a single system for moving digital money. The primary benefit of the cellular structure is that it lowers barriers to entry for payments by using trustless intermediation within the system. The larger purpose of this structure is to create an open foundation for a decentralized financial system in which competition can thrive but which cannot be captured by private interests.
Electron Beam Brightness and Undulator Radiation Brilliance for a Laser Plasma Acceleration Based Free Electron Laser

We report here on spontaneous undulator radiation and free electron laser calculations after a 10-m long transport line (COXINEL) using a Laser Plasma acceleration (LPA) source. The line enables the manipulation of the properties of the produced electron beams (energy spread, divergence, dispersion) in view of light source applications. The electron beam brightness and undulator radiation brilliance are addressed by an analytical approach enabling us to point out the influence of chromatic effects in the COXINEL case.
Management Research and Practice

Along with urban modernization, the changing needs and requirements introduced rapid urban growth and irregular construction. The pressures that economic and technological developments introduced, along with the increasing housing requirements, also changed and transformed the collaborative environments that communities built. One of the places where this change was most obvious was the transformation of the traditional neighborhood patterns into neighborhood units. Thus, the present study aimed to reveal the correlations between neighborhood satisfaction level, community satisfaction and sense of community of the neighborhoods. The research was carried out in Çukurçayır neighborhood, one of the new settlement areas in Trabzon province. All study participants were selected with random sampling and Satisfaction Scale, Neighborhood Attachment Scale and Sense of Community Scale were used to analyze the physical and social properties of the study community. The study data demonstrated that there was a positive and significant correlation between satisfaction, neighborhood attachment and sense of community.
ON THE LABOR MARKET CONSEQUENCES OF ENVIRONMENTAL TAXES

This paper uses individual-level data to estimate the labor market consequences of environmental policies. The focus on workers rather than industries as the unit of analysis allows me to investigate previously unobserved outcomes, such as (i) unemployment rates, labor force participation rates, and the natures of layoffs and new hires and (ii) the distributional effects of these policies, both of which are critical to understanding costs and their distributions associated with environmental policies. Exploiting the introduction of a revenue-neutral carbon tax in British Columbia (BC), I find that environmental taxes, though revenue-neutral, tax away jobs disproportionately, more likely from less-educated workers. In particular, the policy increases the unemployment rates of mediumand low-educated males by 1.4 and 2.4 percentage points, respectively. The policy is implemented mainly at the expense of the low-educated: because of these job losses, some engage in temporary and part-time jobs, and, eventually, some, being discouraged workers, leave the labor force, with the caveat that the effects could, though unlikely, be partially driven by an unobserved differential shock to BC’s labor market. JEL Classification: E24, H23, J2, Q52
Notes on Tracy-Widom Fluctuation Theory

In these notes we discuss a few probability models where the fluctuations of a certain random variable are governed not by the classical central limit theorem, but by a distribution called the Tracy-Widom distribution. This random variable is closely connected to determinantal processes: it turns out that it is distributed as the largest point of a determinantal point process on the real line where the kernel K is the so-called Airy kernel. This kind of fluctuations arises (or is believed to arise) in a surprising variety of models: eigenvalues of random matrices, longest increasing subsequences of random permutations, shape fluctuations in first and last passage percolation, polynuclear growth models, frozen region of a random domino tiling of the aztec diamond, totally asymmetric exclusion process. And the list doesn’t stop here. For this reason, physicists say that these models belong to the same universality class.
Towards Simulation-Based Preplanning for Experimental Analysis of Nudging

People often make irrational decisions. With digital nudging, decisions made in online environments can be guided beneficially by adapting design elements of the user-interface and thus the user’s choice environment. To evaluate the effectiveness of different nudging methods, modeling and simulation can be used. In this paper, we make a step towards preplanning of experiments to analyze nudging methods via simulation. To this end, we provide a model that replicates human behavior based on an experiment, that addresses gaming behavior in a digital environment. In a second step, the model is extended using several nudging methods in order to adapt the gamers’ decision-making. Experiments are presented that outline the model’s capability to produce plausible results concerning human gaming behavior as well as the effects of nudging methods on decision-making.
Expanding the (kaleido)scope: A literature perspective on using brain-computer interfaces for neurorehabilitation in children

: Rehabilitation applications using brain-computer interfaces (BCI) have recently shown encouraging results for motor recovery. Effective BCI neurorehabilitation has been shown to exploit neuroplastic properties of the brain through mental imagery tasks. However, these applications and results are currently restricted to adults. A systematic search reveals there is essentially no literature describing motor rehabilitative BCI applications that use electroencephalograms (EEG) in children, despite advances in such applications with adults. Further inspection highlights limited literature pursuing research in the field, especially outside of neurofeedback paradigms. Then the question naturally arises, do current literature trends indicate that EEG based BCI motor rehabilitation applications could be translated to children? To provide further evidence beyond the available literature for this particular topic, we present an exploratory survey examining some of the indirect literature related to motor rehabilitation BCI in children. Our goal is to establish if evidence in the related literature supports or discourages research on this topic and if the related studies can help explain the dearth of current research in this area. The investigation found positive literature trends in the indirect studies which support translating these BCI applications to children and provide insight into potential pitfalls perhaps responsible for the limited literature. Careful consideration of these pitfalls in conjunction with support from the literature emphasize that fully realized motor rehabilitation BCI applications for children are feasible and would be beneficial.
DISCUSSION OF TWO PHOTOGRAMMETRIC TECHNIQUES

This paper aims to present the process of an architectural photogrammetry application that has combined two existing techniques; digital image rectification and monoscopic multi-image measurement systems. The case considered, which is an early 19th century Prussian monument, is Defensionskaserne in Minden, Germany. This architectural object may be defined as a prism with only one richly ornamented surface. It is the 100 m long East elevation that is mainly composed of a series of sub-planes. These sub-planes can be abstracted into rectangles at different depths. The orthogonal composition of the facade has been considered suitable for single image rectification and ortho-imaging. The peculiar longness of the facade has necessitated a three stepped bundling during the multi-image measurements. Scaled handling of textures via rectification is an important tool that provides base for production of digital maps, which are indispensable parts of architectural conservation projects. Measurements of architectural elements, structural and material characteristics, damages, alterations, intervention decisions, etc. can be mapped on rectified surfaces. The problem of hidden area in rectifications via perspective correction was solved in Photoshop after the processing in MSR by Rolleimetric. Photo 3D, which is an easy to work with software, was considered sufficient to derive data for the textured model. Consequently, modelling of the monument at its present, past and future states is desired in conservation projects. The measuring system of CDW from Rolleimetric has provided accurate results in handling overlapping photographs taken from different angles of this long object. 3D data was exported to CAD system for modelling. Therefore, these combined techniques of photogrammetry have provided the visual base necessary for the development of an architectural heritage conservation project.
THE SIMPSONS AND THE SAVIOR TEACHER/DEFICIT PARENT IN POPULAR CULTURE

Abstract: The savior teacher/ deficit parent narrative has become a public pedagogy in America, evidenced by the rise of Teach for America, and the threat of extreme neoliberal education reforms by the Trump administration. In this paper, I examine how the popular television show, The Simpsons, upholds and challenges familiar tropes of the savior teacher/ deficit parent narrative. Drawing on Michael Apple’s theory of the enterprising individual as a trait of neoliberal education ideology, I analyze the ways in which the episode “Lisa’s Substitute” strays from predictable narratives through a focus on parent/ child relationship vs. teacher/ student relationship. I conclude that while this episode highlights and satirizes tropes of the savior teacher/ deficit parent narrative, ultimately, the resolution does not challenge assumptions about working class parents as a barrier to their children’s success or the missionary role of teacher saviors.
PLAYING POOL WITH π ( THE NUMBER π FROM A BILLIARD POINT OF VIEW )

The remarkable book of V. I.Arnold on differential equations [1] starts with the following sentence: “The notion of the configuration space alone let us solve a very difficult mathematical problem. ” Then the problem is formulated and solved. The result of this article confirms Arnold’s idea to use configuration space for another problem, the problem of calculating the number π with any precision. There are many ways to calculate π with a good precision; some of them are known from ancient times, some are pretty recent. The methods use various elegant ideas [2]: geometric (inscribing and circumscribing regular polygons around a circle gives, in particular, the ancient values 31 7 and 3 10 71 for π); number theory (continued fractions allow us to find the regular fraction 355/113 as the simplest approximation for π accurate to the one millionth place); analytical (that use series, integrals, and infinite products); and many others (e.g., the Monte Carlo Method) which require modern electronic devices – powerful calculators and computers. There is also an interesting experimental method for finding π discovered by a French mathematician Georges Louis Leclerc Comte de Buffon (1707–1788) in his article “Sur le jeu de franc-carreau” [3] published in 1777. Buffon suggested dropping a needle of length L = D/2 at random on a grid of parallel lines of spacing D. One drops the needle N times and counts the number of intersections, R, with the grid lines (note that since the needle is shorter than the distance between two consecutive grid lines, it intersects each time either exactly one line or none of the lines). The frequency of intersection with a line is R/N ; on the other hand, one can show that the probability for the needle to intersect a grid line is 1/π (for an arbitrary needle of length, L, the probability equals 2L/πD). Equating the
A Novel Intrusion Detection Model Using a Fusion of Network and Device States for Communication-Based Train Control Systems

Security is crucial in cyber-physical systems (CPS). As a typical CPS, the communication-based train control (CBTC) system is facing increasingly serious cyber-attacks. Intrusion detection systems (IDSs) are vital to protect the system against cyber-attacks. The traditional IDS cannot distinguish between cyber-attacks and system faults. Furthermore, the design of the traditional IDS does not take the principles of CBTC systems into consideration. When deployed, it cannot effectively detect cyber-attacks against CBTC systems. In this paper, we propose a novel intrusion detection method that considers both the status of the networks and those of the equipment to identify if the abnormality is caused by cyber-attacks or by system faults. The proposed method is verified on a hardware-in-the-loop simulation platform of CBTC systems. Simulation results indicate that the proposed method has achieved 97.64% true positive rate, which can significantly improve the security protection level of CBTC systems.
GermEval 2015: LexSub – Proceedings of the First Workshop on German Lexical Substitution

Lexical substitution has been an area of intensive research for much of the past decade. A significant portion of research interest in the task has centered around using lexical paraphrasing as a testbed to evaluate (vector-based) semantic models. More recently there is growing interest in lexical substitution as a standalone task. This is fueled by both the progress of the state of the art in solving this task and by the increasing number of practical applications for which lexical substitution is a core technology. In this talk I will provide a brief overview of the recent advances in lexical substitution, and present our work that aimed to improve the accuracy of lexical substitution by leveraging the power of supervised models (while preserving the ability to address the problem in an open vocabulary setting). In the second part of the talk, I will present some practical applications that can benefit from an accurate lexical substitution system and discuss some aspects of the task (such as coverage, evaluation metrics, etc.) that seem to be important from an application perspective.
Iterative Analog–Digital Multi-User Equalizer for Wideband Millimeter Wave Massive MIMO Systems

Most of the previous work on hybrid transmit and receive beamforming focused on narrowband channels. Because the millimeter wave channels are expected to be wideband, it is crucial to propose efficient solutions for frequency-selective channels. In this regard, this paper proposes an iterative analog–digital multi-user equalizer scheme for the uplink of wideband millimeter-wave massive multiple-input-multiple-output (MIMO) systems. By iterative equalizer we mean that both analog and digital parts are updated using as input the estimates obtained at the previous iteration. The proposed iterative analog–digital multi-user equalizer is designed by minimizing the sum of the mean square error of the data estimates over the subcarriers. We assume that the analog part is fixed for all subcarriers while the digital part is computed on a per subcarrier basis. Due to the complexity of the resulting optimization problem, a sequential approach is proposed to compute the analog phase shifters values for each radio frequency (RF) chain. We also derive an accurate, semi-analytical approach for obtaining the bit error rate (BER) of the proposed hybrid system. The proposed solution is compared with other hybrid equalizer schemes, recently designed for wideband millimeter-wave (mmWave) massive MIMO systems. The simulation results show that the performance of the developed analog–digital multi-user equalizer is close to full-digital counterpart and outperforms the previous hybrid approach.