Miracle-dz/UniFAR-FTUs huggingface dataset:
A Practitioner’s Toolkit for Polycystic Ovary Syndrome Counselling

Polycystic ovary syndrome (PCOS), a frequently occurring health issue, has a significant effect on the cosmetic, metabolic, psychosocial and fertility aspects of women. A multidisciplinary team approach based on the core pillars of screening, assessment and counselling to detect, prevent and treat physiological and psychological issues in PCOS is very essential. Women are treated medically, but the psychosocial part is often forsaken. Hence, counselling forms an integral part of PCOS management that enables enhanced clinical outcomes and patient satisfaction. Digital tools and PCOS support groups have built an opportunity for physicians to create awareness, help timely diagnosis and overcome PCOS symptoms. The absence of clear guidelines to tackle the often less discussed aspects of PCOS warrants the need for consensus on PCOS counselling. This review summarizes the biopsychosocial health, clinical assessment and treatment strategies of PCOS and associated co-morbidities. The review article will discuss the clinician's role in patient education with the special focus on counselling of females with PCOS regardless of age group.
Application of the Automatic Control System in the Production of Liquors

The application of automatic control system in liquor production processes including liquor blending,liquor filtration,liquor transportation,liquor filling and liquor packing etc.was investigated.Some liquor production techniques were innovated as follows:automatic compensation of margin temperature in liquor pots,two-way cleanup of residual liquor in liquor pipelines,and comprehensive utilization of multiple pipelines during liquor automatic blending etc.Besides,Profibus bussing techniques had been applied in the control and management system in liquor production to achieve real-time online data inquiry and real-time control.Automatic liquor boxes conveying control system had also been used for warehouse input of product liquor. (Tran.by YUE Yang)
Power Converter Solutions for Industrial PV Applications—A Review

As the use of photovoltaics becomes more widespread, new technologies for more efficient energy generation, transmission, and distribution based on power electronics converters are being developed. The most common applications are grid-on, energy storage, hybrid, and high voltage gain applications. These applications impose several additional requirements in the design of power converters associated with the solar battery’s maximum power tracking and operation in a wide range of input currents and voltages. The practical realization of such solutions can be implemented on the basis of various topologies, which requires a preliminary application of criteria for assessing their effectiveness. The paper conducts a comparison of different topologies on power converters based on two parameters that describe their cost and power loss for various PV applications. For a straightforward study, these parameters are represented using the gain factor, which allows for an accurate comparison of the efficiency of various types of converters.
Microsoft Word-5751309-file00.docx

words: 255 Introduction words: 712 Discussion words: 963 Non-standard abbreviations: NHR, nuclear hormone receptor; RCT, reverse cholesterol transport; LXR, liver X receptor; ABCA1, ATP-binding cassette transporter A1; ABCG1, ATP-binding cassette transporter G1; ABCG5, ATP-binding cassette transporter G5; ABCG8, ATP-binding cassette transporter G8; LDL-C, low density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol; TG, triglyceride; apo B, apolipoprotein B; CETP, cholesteryl ester transfer protein; FAS, fatty acid synthase; SCD1, stearoyl-CoA desaturase 1; IDOL, inducible degrader of LDL receptor; Angptl3, angiopoietin like 3 protein; LPL, lipoprotein lipase; CYP7A1, cytochrome P450 7A1; PK, pharmacokinetics; PD, pharmacodynamics; FPLC, fast protein liquid chromatography; MR, magnetic resonance; CSI, cholesterol saturation index; FGF21, fibroblast growth factor 21; LLQ, lower limit of quantitation; mg/dl, milligrams per deciliter; FOV, field of view; TR, repetition time; TE, echo time. Recommended Section: Drug Discovery and Translational Medicine This article has not been copyedited and formatted. The final version may differ from this version. JPET Fast Forward. Published on December 2, 2014 as DOI: 10.1124/jpet.114. 219923 at A PE T Jornals on M ay 1, 2022 jpet.asjournals. org D ow nladed from
Separations in Proof Complexity and TFNP

It is well-known that Resolution proofs can be efficiently simulated by Sherali-Adams (SA) proofs. We show 1, however, that any such simulation needs to exploit huge coefficients: Resolution cannot be efficiently simulated by SA when the coefficients are written in unary. We also show that Reversible Resolution (a variant of MaxSAT Resolution) cannot be efficiently simulated by Nullstellensatz (NS). These results have consequences for total NP search problems. First, we characterise the classes PPADS, PPAD, SOPL by unary-SA, unary-NS, and Reversible Resolution, respectively. Second, we show that, relative to an oracle, PLS $\nsubseteq$ PPP, SOPL $\nsubseteq$ PPA, and EOPL $\nsubseteq$ UEOPL. In particular, together with prior work, this gives a complete picture of the black-box relationships between all classical TFNP classes introduced in the 1990s.1This is an extended abstract. For the full version of this article, please refer to [GHJ+22b].
Synergistic Antioxidant Activity and Enhanced Stability of Curcumin Encapsulated in Vegetal Oil-Based Microemulsion and Gel Microemulsions

Curcumin, due to its antioxidant, antibacterial, anti-inflammatory, and antitumoral activity, has attracted huge attention in applications in many fields such as pharmacy, medicine, nutrition, cosmetics, and biotechnology. The stability of curcumin-based products and preservation of antioxidant properties are still challenges in practical applications. Stability and antioxidant properties were studied for curcumin encapsulated in O/W microemulsion systems and three related gel microemulsions. Only biodegradable and biocompatible ingredients were used for carriers: grape seed oil as oily phase, Tween 80, and Plurol® Diisostearique CG as a surfactant mix, and ethanol as a co-solvent. For the gel microemulsions, water-soluble polymers, namely Carbopol® 980 NF, chitosan, and sodium hyaluronate were used. The influence of UVC irradiation and heat treatment on the degradation kinetics of curcumin in the formulations was studied. Because of the antioxidant character of the microemulsion oily phase, the possibility of a synergistic effect between grape seed oil and curcumin was explored. In this study, the high efficiency of the studied drug delivery systems to ensure protection from external degradative factors was confirmed. Also, the influence of the encapsulation in microemulsion and derived gel microemulsion systems on the antioxidant capacity curcumin was studied, and a synergistic effect with vegetal oil was demonstrated.
Correlating Rheological Properties of a Gellan Gum-Based Bioink: A Study of the Impact of Cell Density

Here, for the production of a bioink-based gellan gum, an amino derivative of this polysaccharide was mixed with a mono-functionalized aldehyde polyethyleneglycol in order to improve viscoelastic macroscopic properties and the potential processability by means of bioprinting techniques as confirmed by the printing tests. The dynamic Schiff base linkage between amino and aldehyde groups temporally modulates the rheological properties and allows a reduction of the applied pressure during extrusion followed by the recovery of gellan gum strength. Rheological properties, often related to printing resolution, were extensively investigated confirming pseudoplastic behavior and thermotropic and ionotropic responses. The success of bioprinting is related to different parameters. Among them, cell density must be carefully selected, and in order to quantify their role on printability, murine preostoblastic cells (MC3T3-E1) and human colon tumor cells (HCT-116) were chosen as cell line models. Here, we investigated the effect of their density on the bioink’s rheological properties, showing a more significant difference between cell densities for MC3T3-E1 compared to HCT-116. The results suggest the necessity of not neglecting this aspect and carrying out preliminary studies to choose the best cell densities to have the maximum viability and consequently to set the printing parameters.
Designing Robust Biotechnological Processes Regarding Variabilities using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design

Development and optimization of biopharmaceutical production processes with cell cultures is cost- and time-consuming and often performed rather empirically. Efficient optimization of multiple objectives such as process time, viable cell density, number of operating steps & cultivation scales, required medium, amount of product as well as product quality depicts a promising approach. This contribution presents a workflow which couples uncertainty-based upstream simulation and Bayes optimization using Gaussian processes. Its application is demonstrated in a simulation case study for a relevant industrial task in process development, the design of a robust cell culture expansion process (seed train), meaning that despite uncertainties and variabilities concerning cell growth, low variations of viable cell density during the seed train are obtained. Compared to a non-optimized reference seed train, the optimized process showed much lower deviation rates regarding viable cell densities (<10% instead of 41.7%) using five or four shake flask scales and seed train duration could be reduced by 56 h from 576 h to 520 h. Overall, it is shown that applying Bayes optimization allows for optimization of a multi-objective optimization function with several optimizable input variables and under a considerable amount of constraints with a low computational effort. This approach provides the potential to be used in the form of a decision tool, e.g., for the choice of an optimal and robust seed train design or for further optimization tasks within process development.
Development, Characterization and Optimization of the Anti-Inflammatory Influence of Meloxicam Loaded into a Eucalyptus Oil-Based Nanoemulgel

The purpose of the present study was to explore the influence of a certain natural essential oil, namely eucalyptus oil, as an anti-inflammatory agent in addition to its prospective role in enhancing the action of meloxicam in reducing inflammation. As far as we know, this has been the first integration of meloxicam and eucalyptus essential oil into a nanoemulgel formulation intended for topical use. Primarily, eucalyptus oil was utilized in developing a nanoemulsion formulation incorporating meloxicam. A 22 factorial design was constructed using two independent variables (oil concentration and surfactant concentration) with two responses (particle size and % of in vitro release). One optimized formula was selected depending on the desirability function and subjected to a stability study. The optimized nanoemulsion was mixed with HPMC as a gelling agent to produce a meloxicam-loaded nanoemulgel, which was examined for its properties, stability, in vitro release and ex vivo permeation. Eventually, the anti-inflammatory activity was evaluated and compared with a placebo and corresponding gel formulation. The developed nanoemulgel revealed acceptable physical characteristics to be applied topically. Studying of the in vitro release was conducted successfully for 6 h. The ex vivo permeation from the nanoemulgel formulations was prompted, showing an appropriate value of the steady-state transdermal flux (SSTF). As a final point, the anti-inflammatory activity of the developed nanoemulgel revealed a valued anti-inflammatory influence. Additionally, the concurrence of eucalyptus essential oil and meloxicam was assured, and their potential in combating and lowering inflammation was supported.
Design and Control of an Autonomous Photovoltaic System with Battery Charge Regulateur using the MPPT Control Followed by PI Correctors

: An Autonomous photovoltaic (PV) system requires a battery charger to store energy for consumption during the night and during days with low irradiation. This paper presents the design of the PV charger system modulator and controller implemented with the asymmetric primary inductance converter (SEPIC). The designed SEPIC is controlled by the MPPT (Pando) command to extract the maximum power of the PV generator. To the used MPPT control, a PI control regulator has been added to manage the charge loop of the battery. Subsequently, a BOOST converter has been associated with the system to adapt the output voltage of the battery to the load. The modeling of the state space is done to determine the transfer function of the converters (SEPIC and BOOST). The values of the PI correctors (Kp and Ki) are obtained using the method of Ziegler Nichols. Finally, we simulated and analyzed the performance of a 250W stand-alone photovoltaic power system on MATLAB- Simulink.
Resources, Environment and Sustainability Resource recovery and freshwater ecosystem restoration — Prospecting for phytoremediation potential in wild macrophyte stands

The primary aim of this study was to understand the factors, e.g., harvest frequency and plant community type, that can facilitate optimising phytoextraction in wild macrophyte communities as part of a strategy for water-quality improvement and resource recovery. This was achieved by surveying wild macrophyte communities and quantifying standing stocks of key nutrient pollutants such as N and P, and a range of other recoverable macro and micro-nutrients (Ca, K, Mg, Cu, Fe, Mn, Mo, Zn, Na and Cr). By scaling-up the pollutant export potential over a decade, it was determined which harvest strategy and plant community types provide the greatest levels of nutrient export. Grime’s CSR plant strategy framework was used to categorise each surveyed community, where large-statured, higher biomass producing competitor and stress tolerator-type communities were compared with ruderal-type communities that have rapid growth and high nutrient acquisition but smaller standing biomass and statures. High biomass plant communities containing competitor or stress tolerator species, produce greater standing stocks of macronutrients (such as N and P) for harvesting, while yields of micronutrient-type pollutants are more likely to be influenced by specific physiological traits that determine leaf tissue concentration. Utilising a high frequency harvest regime over a multi-year time scale suggested that small fast-growing ruderals could yield 4–6 times the concentration of macronutrients and micronutrients for export compared to competitor or stress tolerator-dominated communities e.g., P yields from ruderals were 25 g/m 2 versus 5 g/m 2 from competitor/stress tolerator-dominated communities. These results emphasise the need to consider both the plant community and the harvesting regime when using phytoextraction as a management tool. We anticipate that these results will help guide environmental managers in their approach in developing circular economy schemes that improve water quality through nutrient export.
SARS-CoV-2 Delta VOC in a Paucisymptomatic Dog, Italy

Since the very beginning of the COVID-19 pandemic, SARS-CoV-2 detection has been described in several animal species. A total of 625 outbreaks in animals have been reported globally, affecting 17 species in 32 countries and the human source of infection has been recognized including pet owners, zookeepers, and farmers. In this report, we describe the case of a paucisymptomatic dog in Italy infected with SARS-CoV-2 from a household with three confirmed human cases of COVID-19 living in Pesaro (Marche region, Italy). The dog showed high viral RNA titers in the nasal and oropharyngeal swabs. In the nasal swab, SARS-CoV-2 RNA lasted for a least a week. By sequencing, the strain was assigned to the AY.23 lineage (PANGO), one of the sub-lineages of the major SARS-CoV-2 Delta variant of concern (VOC). Although we did not process the swabs of the three human cases, we strongly suspect a human origin for the dog infection. In this regard, AY.23 sequences, although never released thus far in the Marche region, were detected in the neighboring regions. Our findings highlight once more the need for a One Health approach for SARS-CoV-2 surveillance, management, and control, thus preventing viral spillover from animals to humans.
Perinatal Dioxin Exposure and Attention Deficit Hyperactivity Disorder (ADHD) Symptoms in Children Living in a Dioxin Contamination Hotspot in Vietnam

We examined children in Da Nang, a dioxin contamination hotspot in Vietnam, twice at 5 and 8 years of age, and investigated sex- and age-dependent differences in the effects of dioxin exposure on attention deficit hyperactivity disorder (ADHD) symptoms. We also studied autistic traits in children with ADHD symptoms. A total of 163 children participated in follow-up surveys at 5 and 8 years of age and were included in the present analysis. ADHD symptoms were assessed using an ADHD rating scale with inattention and hyperactivity-and-impulsivity (hyperactivity) subscales. Autistic behaviors were evaluated using the Autism Spectrum Rating Scale (ASRS). Perinatal dioxin exposure was indicated by dioxin levels in maternal breast milk. In boys, hyperactivity scores were significantly higher in the high 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) group only at 5 years of age. In girls, hyperactivity scores at 8 years of age were significantly higher in the high TCDD group, which was significantly associated with those at 5 years of age. In girls, ASRS unusual behavior scores were significantly higher with higher TCDD exposure and hyperactivity scores at 8 years of age. These results suggest that high perinatal TCDD exposure may increase ADHD likelihood and autistic traits, particularly in girls of 7–8 years of age.
Lycium barbarum Polysaccharide Inhibits E. coli-Induced Inflammation and Oxidative Stress in Mammary Epithelial Cells of Dairy Cows Via SOCS3 Activation and MAPK Suppression

Escherichia coli (E. coli) is one of the main causative agents of mastitis in dairy cows. Lycium barbarum polysaccharide (LBP) has a variety of physiological effects as it has antioxidants, it is hypoglycemic, it has anti-aging properties, it is neuroprotective, immune boosting, and it has anti-inflammatory effects in vivo and in vitro. In this study, we examined whether LBP affects the expression of pro-inflammatory factors, and the mitogen-activated protein kinase (MAPK) signaling pathway via activation of the suppressor of cytokine signaling-3 (SOCS3) in E. coli-induced primary bovine mammary epithelial cell (pbMEC) inflammatory responses. The experiment was designed with the control group (NC), cells were treated with E. coli for 6 h as the E. coli group (E. coli), and cells were pretreated with 100 μg/mL or 300 μg/mL of LBP for 24 h, followed by the addition of E. coli for 6 h as the E. coli + low level (E + LL) or E. coli + high level (E + HL) groups. The addition of LBP did not alter the cell viability of pbMEC in a dose-dependent assay. Pretreatment with LBP significantly decreased the expression of pro-inflammatory genes (IL1B, MAPK14, COX-2, iNOS) and proteins (COX-2, IL-1β, TNF-α) in the cells challenged by E. coli as compared with the control group (p < 0.05). E. coli stimulation significantly increased the production of reactive oxygen species (ROS) and malondialdehyde (MDA) in pbMEC, and decreased the antioxidants’ capacity with regard to decreased superoxide dismutase (SOD) and total antioxidant capacity (T-AOC); however, pretreatment with LBP reversed the oxidative stress and inhibition of antioxidants in cells challenged by E. coli. Moreover, LBP reversed the upregulated expression of the components of the MAPK pathway (increased phosphorylation level of p38, JNK, and ERK), followed by E. coli stimulation. Consistently, cells exposed to E. coli strengthened the staining of p38, whereas pretreatment of LBP weakened the staining of p38 in cells challenged by E. coli. Notably, the expression of SOCS3 was increased by LBP added to the cells in a dose-dependent manner. Additionally, the level of decreased expression of proinflammatory factors (IL-1β, TNF-α, and COX-2) was higher in the E + LL group than in the E + HL group. These results indicate that LBP pretreatment is effective in the alleviation of E. coli-induced inflammatory and oxidative responses in pbMEC through activation of SOCS3 and depression of MAPK signaling. As such, this might help us to develop molecular strategies for mitigating the detrimental effects of clinical bovine mastitis.
Modeling and prediction of the softening temperature of coal ash

The model of the softening temperature of coal ash was built based on Elman network.The coal ash compositions were employed as the input vectors and the measured ash softening temperature as the outputs of the neural network.In order to select the optimal prediction model,the relationship between input vector dimensions,the number of hidden layer,the activation functions and the results of the prediction model was discussed respectively.Then,the selected optimal model was used to predict the softening temperature of the test samples.The results show that the prediction accuracy is higher than the conventional BP network.From the optimal prediction model,can draw a conclusion that there is an optimal amount of coal ash composition analysis.
The Transcription Regulator YgeK Affects Biofilm Formation and Environmental Stress Resistance in Avian Pathogenic Escherichia coli

Simple Summary Avian pathogenic Escherichia coli (APEC) is the pathogen responsible for colibacillosis in poultry. Transcriptional regulator ygeK has been shown to decrease APEC’s flagellar formation ability, bacterial motility ability, serum sensitivity, and adhesion ability. However, we did not study the effects of ygeK on biofilm formation and environmental stress resistance in APEC. In this study, we investigated ygeK in APEC biofilm formation and bacterial resistance to different environmental stresses. We also analyzed the multi-level regulation of ygeK in APEC and investigated associations between differentially expressed proteins and key ygeK targets. This work provides a basis for further analysis of APEC pathogenesis mechanisms. Abstract Avian pathogenic Escherichia coli (APEC) is one of the most common pathogens in poultry and a potential gene source of human extraintestinal pathogenic E. coli (ExPEC), leading to serious economic losses in the poultry industry and public health concerns. Exploring the pathogenic mechanisms underpinning APEC and the identification of new targets for disease prevention and treatment are warranted. YgeK is a transcriptional regulator in APEC and is localized to the type III secretion system 2 of E. coli. In our previous work, the transcription factor ygeK significantly affected APEC flagella formation, bacterial motility, serum sensitivity, adhesion, and virulence. To further explore ygeK functions, we evaluated its influence on APEC biofilm formation and resistance to environmental stress. Our results showed that ygeK inactivation decreased biofilm formation and reduced bacterial resistance to environmental stresses, including acid and oxidative stress. In addition, the multi-level regulation of ygeK in APEC was analyzed using proteomics, and associations between differentially expressed proteins and the key targets of ygeK were investigated. Overall, we identified ygeK’s new function in APEC. These have led us to better understand the transcriptional regulatory ygeK and provide new clues about the pathogenicity of APEC.