Miracle-dz/UniFAR-FTUs huggingface dataset:
The IL-1 receptor-related T1 antigen is expressed on immature and mature mast cells and on fetal blood mast cell progenitors.

Expression of the T1 gene, also known as ST2, DER4, and Fit-1, has been shown to be associated with cell proliferation. It gives rise to two different mRNAs that encode a receptor-like protein and a soluble molecule representing the ectodomain of the receptor form. Although T1 is a member of the IL-1R family, its biologic function is currently unknown. In this study, we have analyzed the expression of the T1 surface Ag in murine hemopoietic organs. Mast cells (MCs) were shown to be the only identifiable cell lineage that expressed T1 at high levels. T1 expression was found on cultured bone marrow-derived immature MCs. Similarly, freshly isolated connective tissue-type MCs from the i.p. cavity were also shown to express high levels of T1. Interestingly, the earliest detectable committed MC precursor isolated from fetal blood (FB) at day 15.5 of gestation, but not circulating hemopoietic stem cells in FB, also expresses high level of T1. Since FB promastocytes lack expression of the high affinity IgE receptor (Fc epsilonRI), T1 expression precedes expression of Fc epsilonRI in MC ontogeny. The finding that the T1 Ag is selectively expressed at several stages during development of the MC lineage suggests that this cell surface molecule, in combination with the well-established markers c-Kit and Fc epsilonRI, should be valuable for studying the MC lineage.
In vitro susceptibility of filamentous fungi to itraconazole, voriconazole and posaconazole by Clinical and Laboratory Standards Institute reference method and E‐test

The use of anti‐fungal agents has increased dramatically in recent years and new drugs have been developed. Several methods are available for determinations of their specific biological activities, i.e. the standard method for minimum inhibitory concentration‐determination is described in M‐38 [Clinical and Laboratory Standards Institute document M‐38 (CLSI M‐38)]. However, alternative methods, such as the E‐test, are currently available in Mycology laboratories. The susceptibilities of clinical isolates of Aspergillus spp. (n = 29), Fusarium spp. (n = 5), zygomycetes (n = 21) and Schizophyllum (n = 1) were determined for itraconazole, voriconazole and posaconazole, using the CLSI M‐38‐A broth dilution method and also by the E‐test. A good overall agreement (83.7%) between the two methods for all drugs and organisms was observed. Analyses of voriconazole showed a better agreement (93%) between the methods than posaconazole and itraconazole (85% and 74% respectively). Aspergillus spp. were the most susceptible fungi to the anti‐fungal agents tested in this study. Posaconazole was the most active drug against filamentous fungi in vitro, followed by itraconazole and voriconazole. The latter (voriconazole) demonstrated no significant in vitro activity against zygomycetes.
Is it time to abandon RHAMM/HMMR as a candidate antigen for immunotherapy of acute myeloid leukemia?

Amajor dilemma in the treatment of acute myeloid leukemia (AML) is the fact that current chemotherapies lead to complete remission in the majority of patients but overall survival at five years is less than 25%. [1][1] Treatment failure is ascribed to the presence of small numbers of tumor cells (
Aluminum–Titanium Alloy Back Contact Reducing Production Cost of Silicon Thin-Film Solar Cells

In this study, metal films are fabricated by using an in-line reactive direct current magnetron sputtering system. The aluminum–titanium (AlTi) back contacts are prepared by changing the pressure from 10 mTorr to 25 mTorr. The optical, electrical and structural properties of the metal back contacts are investigated. The solar cells with the AlTi had lower contact resistance than those with the silver (Ag) back contact, resulting in a higher fill factor. The AlTi contact can achieve a solar cell conversion efficiency as high as that obtained from the Ag contact. These findings encourage the potential adoption of AlTi films as an alternative back contact to silver for silicon thin-film solar cells.
Robust Optimization of Storage Investment on Transmission Networks

This paper discusses the need for the integration of storage systems on transmission networks having renewable sources, and presents a tool for energy storage planning. The tool employs robust optimization to minimize the investment in storage units that guarantee a feasible system operation, without load or renewable power curtailment, for all scenarios in the convex hull of a discrete uncertainty set; it is termed ROSION-Robust Optimization of Storage Investment On Networks. The computational engine in ROSION is a specific tailored implementation of a column-and-constraint generation algorithm for two-stage robust optimization problems, where a lower and an upper bound on the optimal objective function value are successively calculated until convergence. The lower bound is computed using mixed-integer linear programming and the upper bound via linear programming applied to a sequence of similar problems. ROSION is demonstrated for storage planning on the IEEE 14-bus and 118-bus networks, and the robustness of the designs is validated via Monte Carlo simulation.
Enhancement of SIMPLE-O : Weighted Process Improvement for Automatic Essay Assessment in E-Learning System

The advancement in computer and telecommunication technology has been effecting changes in every area, including on education area, where the learning system is shifting from conventional way to a future technology way called as “E-Learning”. E-Learning concept means that all learning activities are delivered electronically, also the assessment can be done using online communication, from answering the quizzes, and getting the final score/grading. This thing will give benefit to the instructors and students because to the time consumed for the assessment will be much shorter, more effective and efficient. Another benefit from this system is that the coring will be much faster and accurate. And also this system can handle bigger class with more students. The assessment model whether by conventional or E-Learning, based on two main formats: an Objective Format and Essay Format. Examination in essay is an indicator to determine student’s capability where choices of the answers are not provided. The methods used in automated essay grading system nowadays are still under research because they need to follow some specific rules. Some of the methods are Natural Language Processing, Statistical Approach, Bayesian Text Classification, and Latent Semantic Analysis. Essay question is a format where answer is not provided, students have to answers with correct sentences, and this condition could lead to the different answer which comes up from every participant of the test. On the previous system called SIMPLE-O version 1.0, the algorithm and weighted value was already implemented. The process of essay assessment was running well and also the final mark of the assessment was successfully generated by the system. This research will build a system called SIMPLE-O, using LSA method, based on Indonesian Language and add a weighted on words that considered important from chosen keyword. The weight value will be given by multiplying value by 2. Aside, on this system, similar words will be carefully watched, since it becomes a significant factor for the system using Indonesian language. On the previous research, this system generated the result of Agreement value for human raters in small-size class is 68.90%-94.64% and middle-size class is 77.18%-98.42%. This enhancement research had carried out to implement different weighted value by using weight scheme SICBI, where the keyword is adjusted to improve the Agreement value of human raters into 73.12%-94.33% for middle-size class. Besides, the SVD process is also being improved by implementing better and more efficient algorithm, so the time for computation process will be shorter and more efficient, which is 6.47 times faster. In addition, this research also improves the aspect of user comfort and friendliness to interact with the system and also to reduce the number of possibility mistypes of student answers.
Monument annuity as economic instrument- from theory to Croatian practice

Spomenicka renta je naknada koja se placa na koristenje fiksnih resursa poput zemlje, prirodnih resursa ili u slucaju kulturnih spomenika. Teorija renti u fokusu je istraživanja brojnih ekonomista, osobito onih koji su se u svojim istraživanjima bavili istraživanjem zemljisnih renti poput W. Petty, A. Smith, D.Ricardo,T.R. Malthus, K.Marx, P.A. Samuelson i drugi. Spomenicka renta predstavlja nezamjenjivi ekonomski instrument pomocu kojeg se ekonomska vrijednost spomenika utvrđuje na tržistu. Kroz svoju funkciju spomenicka renta omogucava upravljanje zasticenom spomenickom bastinom kao I ostvarenje osnovnih ciljeva koje se zastitom spomenika želi ostvariti. Time se ne ostvaruje samo zastita naslijeđene spomenicke bastine vec i racionalno koristenje spomenickih vrijednosti u gospodarskom razvoju.
Pedestrian Detection in RGB-D Data Using Deep Autoencoders

Recent popularity of RGB-D sensors mostly comes from the fact that RGB-images and depth maps supplement each other in machine vision tasks, such as object detection and recognition. This article addresses a problem of RGB and depth data fusion for pedestrian detection. We propose pedestrian detection algorithm that involves fusion of outputs of 2D- and 3D-detectors based on deep autoencoders. Outputs are fused with neural network classifier trained using a dataset which entries are represented by pairs of reconstruction errors of 2D- and 3D-autoencoders. Experimental results show that fusing outputs almost totally eliminate false accepts (precision is 99.8%) and brings recall to 93.2% when tested on the combined dataset that includes a lot of samples with significantly distorted human silhouette. Though we use walking pedestrians as objects of interest, there are few pedestrian-specific processing blocks in this algorithm, so, in general, it can be applied to any type of objects.
Continuing increases in sexual risk behavior and sexually transmitted diseases among men who have sex with men: San Francisco, Calif, 1999-2001, USA.

We recently reported on worrisome increases in sexual risk behavior, sexually transmitted diseases (STDs), and HIV incidence among men who have sex with men (MSM) during a period of increasing use of highly active antiretroviral therapy (HAART), from 1994 to 1999.1 We have since obtained data on sexual risk behavior for 2000 and 2001. In addition, we have added to our surveys questions on whether unsafe sex was occurring with partners of unknown HIV serostatus, updated trends in male rectal gonorrhea, and provided data on primary and secondary syphilis cases among MSM. As previously reported, the Stop AIDS Project conducts serial cross-sectional surveys of MSM in a variety of community settings in the course of outreach health education. The street-based intercept survey asks questions about sexual behavior in the preceding 6 months, including anal sex, condom use, number of sexual partners, and knowledge of partners’ HIV serostatus. Overall, 10 568 MSM completed the survey between 1999 and 2001. The proportion of MSM reporting any anal sex in the last 6 months increased from 67% in 1999 to 74% in 2001 (Figure 1a ▶). The proportion of respondents reporting any unprotected anal sex increased from 32% to 38%, with a parallel increase from 18% to 23% in the proportion reporting unprotected anal sex with 2 or more partners (Figure 1b ▶). Between 1999 and 2001, the proportion reporting unprotected anal sex with 2 or more partners of unknown HIV serostatus increased from 10% to 15% for respondents who reported being HIV-negative and from 19% to 25% for those who said they were HIV-positive (Figure 1c ▶). Although a decline in the number of respondents was noted from 1999 to 2001, there were no substantial shifts in respondents’ age or race over time and no differences in trends in sexual risk behavior within demographic groups. FIGURE 1 —Trends in sexual risk behavior and sexually transmitted diseases among men who have sex with men: San Francisco, Calif, 1999–2001. STD surveillance data corroborate continued increases in sexual risk behavior. Reported cases of male rectal gonorrhea increased from 162 in 1999 (updated from 160 in our prior report1 owing to delays in reporting) to 237 in 2001 (Figure 1d ▶). The number of primary and secondary syphilis cases among MSM increased from only 6 cases in 1998 to 115 cases in 2001. We conclude that the increases in unsafe sex seen from 1994 to 1999, in association with the availability of HAART, were not isolated but rather reflect an ongoing trend. Moreover, data on HIV serostatus of partners suggest that much of this unsafe sex is occurring among partners who are serodiscordant.
Stability Indicating Method Development for Simultaneous Estimation of Ezetimibe and Atorvastatin in Pharmaceutical Formulations by RP-HPLC

Simple, specific, economical and precise high performance liquid chromatographic method for the simultaneous determination of ezetimibe and Atorvastatin in API (active pharmaceutical ingredient) and formulation has been developed and validated. Chromatography was carried out at 30°C on a prepacked Zorbax SB C18 (5 mm, 250×4.6 mm) column with the 0.02 M Potassium dihydrogen phosphate: Acetonitrile: Methanol (10:40:50, v/v/v) was used as the mobile phase. The UV detection was carried at 236 nm. The results obtained showed good agreement with the declared contents. Ezetimibe and Atorvastatin separated in less than 10 min with good resolution and minimal tailing and without interference of excipients. The retention times of ezetimibe and Atorvastatin were 5.7 min and 9.1 min, respectively. The method was linear in the range of 5–50 μg/ml for Ezetimibe concentration with a correlation co-efficient 0.9992 and in the range 5–60 μg/ml for Atorvastatin concentrations having correlation co-efficient 0.9994 and the recovery was 99-102%. The method was validated according to ICH guidelines and the acceptance criteria for accuracy, precision, linearity, specificity and system suitability were met in all cases. The proposed method can be used for quantitative determination of Ezetimibe and Atorvastatin combination from API and formulations.
Development and Evaluation of the Barriers to Nurses’ Participation in Research Questionnaire at a Large Academic Pediatric Hospital

The purposes of this study were to survey nurses at a large pediatric hospital to examine barriers to nursing research and to develop the Barriers to Nurses’ Participation in Research Questionnaire (BNPRQ) in preparation for its use at other institutions. The BNPRQ was created and refined through iterative pilot testing. Exploratory factor analysis was applied, and composite scores were computed for the identified factors. The two latent factors “Research Resources” and “Personal Relevance of Research” were extracted. The independent item “lack of time to do research” represented the largest barrier to research. Factor and item scores differed according to subject characteristics. Findings from this study will be used to create targeted interventions to reduce barriers to research participation prevalent in specific groups of nurses. By using the BNPRQ developed in this study, researchers and administrators at other institutions can identify and address barriers to research among their nurses.
UVA1 irradiation induces deoxyribonuclease dependent apoptosis in cutaneousT‐cell lymphoma in vivo

Cutaneous T‐cell lymphoma (CTCL) is a malignancy of mature T‐cells, predominantly of the helper phenotype, that primarily invade the skin. Different photo‐ and chemotherapeutic treatments are known to be beneficial in early‐stage CTCL. This observation has initiated prospective investigations into the efficacy of phototherapeutic regimens. The purpose of our study was to investigate the ability of medium‐dose UVA1 phototherapy (60 J/cm2) to induce apoptosis (programmed cell death) in skin infiltrating T‐cells of CTCL in vivo. We describe the results of three different staining methods for formalin‐fixed, paraffin‐embedded tissue sections. The in situ end‐labeling (ISEL) procedure, nuclear staining using the DNA‐binding fluorochrome Hoechst 33342, and immunohistochemistry using polyclonal antibodies against recombinant mouse deoxyribonuclease I (DNase I) demonstrated that UVA1 irradiation was able to induce marked apoptosis in CTCL. Thereby, ISEL and Hoechst staining clearly revealed DNA‐condensation and nuclear fragmentation, accompanied by the formation of typical “apoptotic bodies”. The accumulation of DNase I immunoreactivity in the cytoplasm of lymphocytes in UVA1 irradiated skin indicated that DNase I or DNase I‐related endonucleases may have acted as apoptotic endonuclease(s) which were synthesized after UVA1 irradiation prior to their apoptotic elimination.
Automatic Liver Segmentation Method Featuring a Novel Filter for Multiphase Multidetector-Row Helical Computed Tomography

Purpose: To introduce an automatic liver segmentation method that includes a novel filter for multiphase multidetector-row helical computed tomography. Materials and Methods: We acquired 3-phase multidetector-row computed tomographic scans that included unenhanced, arterial, and portal phases. The liver was segmented using our novel adaptive linear prediction filter designed to reduce the difference between filter input and output values in the liver region and to increase these values outside the liver region. Results: The segmentation algorithm produced a mean dice similarity coefficient (DSC) value of 91.4%. Conclusion: The application of our adaptive linear prediction filter was effective in automatically extracting liver regions.
Epigenetic regulation of human α1d‐adrenergic receptor gene expression: a role for DNA methylation in Spl‐dependent regulation

A growing body of evidence implicates α1‐adrenergic receptors (α1ARs) as potent regulators of growth pathways. The three α1AR subtypes (α1aAR, α1bAR, α1dAR) display highly restricted tissue expression that undergoes subtype switching with many pathological stimuli, the mechanistic basis of which remains unknown. To gain insight into transcriptional pathways governing cell‐specific regulation of the human α1dAR subtype, we cloned and characterized the α1dAR promoter region in two human cellular models that display disparate levels of endogenous α1dAR expression (SK‐N‐MC and DU145). Results reveal that α1dAR basal expression is regulated by Sp1‐dependent binding of two promoter‐proximal GC boxes, the mutation of which attenuates α1dAR promoter activity 10‐fold. Mechanistically, chromatin immunoprecipitation data demonstrate that Sp1 binding correlates with expression of the endogenous gene in vivo, correlating highly with α1dAR promoter methylation‐dependent silencing of both episomally expressed reporter constructs and the endogenous gene. Further, analysis of methylation status of proximal GC boxes using sodium bisulfite sequencing reveals differential methylation of proximal GC boxes in the two cell lines examined. Together, the data support a mechanism of methylation‐depen‐dent disruption of Sp1 binding in a cell‐specific manner resulting in repression of basal α1dAR expression. –Michelotti, G. A. , Brinkley, D. M. , Morris, D. P., Smith, M. P., Louie, R. J., Schwinn, D. A. Epigenetic regulation of human α1d‐adrenergic receptor gene expression: a role for DNA methylation in Sp1‐dependent regulation. FASEB J. 21, 1979–1993 (2007)
A Compact Frequency-Reconfigurable Patch Antenna for Beidou (COMPASS) Navigation System

A compact frequency-reconfigurable shorting loaded patch antenna with the capability to switch between three operating bands of Beidou (COMPASS) navigation system (BDNS) (E2, E6, and E5b) is proposed in this letter. The reconfigurable ability of the proposed antenna is achieved via a circular rotational manual motion. The feature of the shorting load is utilized in the proposed antenna. By rotating the top layer of the antenna, the shorting probe in the top layer can be shorted to the ground by different sets of shorting pins with different length in the bottom layer of the antenna, which means that the frequency agility is achieved. Simulated and measured results show that the proposed antenna, which has an overall volume of π×(30 mm ( r))2×12 mm (h), has good performance in all the three operating bands. Thus, the design method proposed in this letter provides a solution for multiband patch antenna that is hard to design using traditional approaches .
Performance analysis of mobility models in sparse Ad-hoc networks

One of the characteristics of ad-hoc networks is their mobility. What pattern each node moves will have a significant impact on the performance of ad-hoc networks. Through analyzing and comparing the performances of four mobility models such as RW, RPGM, FW, MH in sparse ad-hoc networks, it indicates that the impact on the performance of networks is remarkably different when the nodes move in different mobility models. In order to realize the effective communication between the fixed node and move nodes in sparse ad-hoc networks in a large area, we propose a chain mobility model. In this model, the mobile nodes move as a chain, and the stopped node serves as a relay node in communication. The NS2 simulation results show that this model is suitable for communication in the sparse ad-hoc circumstance.
Space Vector PWM scheme without sector identification for an open-end winding induction motor based 3-level inverter

In this paper, a Space Vector Pulse Width Modulation (SVPWM) scheme for open-end winding induction motor based, 3 — level inverter is presented. 3-level inversion is achieved with dual 2-level inverters feeding an open-end winding induction motor drive. The proposed PWM signal generation does not use any sector identification. It does not use look- up tables for generating the switching vectors for the two inverters. The individual inverters are directly driven by the switching vectors without using any translation circuitry. The drive is implemented and tested with a 2HP open-end winding induction motor drive and the experimental results are presented.
Semi-Supervised Clustering Based on Exemplars Constraints

SUMMARY In general, semi-supervised clustering can outperform un-supervised clustering. Since 2001, pairwise constraints for semi-supervised clustering have been an important paradigm in this ﬁeld. In this paper, we show that pairwise constraints (ECs) can a ﬀ ect the performance of clustering in certain situations and analyze the reasons for this in detail. To overcome these disadvantages, we ﬁrst outline some exemplars constraints. Based on these constraints, we then describe a semi-supervised clustering framework, and design an exemplars constraints expectation–maximization algorithm. Finally, standard datasets are selected for experiments, and experimental results are presented, which show that the exemplars constraints outperform the corresponding unsupervised clustering and semi-supervised algorithms based on pairwise constraints.
Exploiting Wikipedia Knowledge for Conceptual Hierarchical Clustering of Documents

In this paper, we propose a novel method for conceptual hierarchical clustering of documents using knowledge extracted from Wikipedia. The proposed method overcomes the classic bag-of-words models disadvantages through the exploitation of Wikipedia textual content and link structure. A robust and compact document representation is built in real-time using the Wikipedia application programmer's interface, without the need to store locally any Wikipedia information. The clustering process is hierarchical and extends the idea of frequent items by using Wikipedia article titles for selecting cluster labels that are descriptive and important for the examined corpus. Experiments show that the proposed technique greatly improves over the baseline approach, both in terms of F-measure and entropy on the one hand and computational cost on the other.