Miracle-dz/UniFAR-FTUs huggingface dataset:
Body Composition and Serum Total Calcium Were Associated With Blood Pressure Among Children and Adolescents Aged 7–18 in China: A Cross-Sectional Study

Background: This study aimed to assess the prevalence of childhood pre-hypertension and hypertension (elevated blood pressure, EBP) and explore their risk factors, especially the role of body composition and serum total calcium on EBP. Methods: From Nov 2013 to Jul 2014, a cross-sectional study was conducted in Hainan and Shaanxi Provinces in China. Two thousand two hundred eighty-three children and adolescents aged 7–18 underwent anthropometric and blood pressure measurements. Fasting blood was collected and serum total calcium was tested. Blood pressure standards from the updated Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents were used to classify BP groups based on age, sex and stature. Results: The overall prevalence of pre-hypertension and hypertension were 8.36 and 7.06%, respectively. Boys, older age, living in Hainan Province, excess adiposity and higher level of serum total calcium were found to be associated with EBP. Lean subjects had an average 3.87 mmHg decrease in systolic blood pressure (SBP) than normal weight groups. In contrary, overweight/obesity had increased SBP (3.69 mmHg) and diastolic blood pressure (DBP) (2.58 mmHg) than the normal weight group. Participants with high-level serum total calcium had a 1.60 mmHg increased SBP and 1.77 mmHg increased DBP than the low-level group. Compared with normal weight individuals, lean subjects appeared to have decreased odds of EBP (OR = 0.65, 95% CI: 0.43–0.98) but overweight/obese individuals were more likely to have EBP (OR = 2.67, 95% CI: 1.68–4.25). High-level of serum total calcium was associated with increased odds of EBP, the OR (95% CI) was 1.51 (1.17–1.94). The restrict cubic spline presented a linear relationship between serum total calcium and OR of EBP (P < 0.001). Conclusions: Body composition and serum total calcium were positively associated with blood pressure in children and adolescents. Serum calcium could be considered as an untraditional risk factors for high blood pressure screening along with other body composition indexes in clinical settings.
Yeasts of Burden: Exploring the Mycobiome–Bacteriome of the Piglet GI Tract

Interactions between the bacteria and fungi in the gut microbiome can result in altered nutrition, pathogenicity of infection, and host development, making them a crucial component in host health. Associations between the mycobiome and bacteriome in the piglet gut, in the context of weaning, remain unknown. Weaning is a time of significant stress, dietary changes, microbial alterations, and a predisposition to infection. The loss of animal health and growth makes potential microbial interventions of interest to the swine industry. Recent studies have demonstrated the diversity and development of the microbiome in the gastrointestinal (GI) tract of piglets during weaning, resulting from the dietary and physiological changes. Despite these advances, the role of the mycobiota in piglet health and its contribution to overall microbiome development remains mostly unknown. In this study we investigated the bacteriome and the mycobiome after weaning in the GI tract organs and feces from 35-day old piglets. Following weaning, the α-diversity and amplicon sequence variants (ASVs) counts of the bacteriome increased, proximally to distally, from the stomach to the feces along the GI tract, while the mycobiome α-diversity and ASV counts were highest in the porcine stomach. β-diversity analyses show distinct clusters based on organ type in the bacteriome and mycobiome, but dispersion remained relatively constant in the mycobiome between organ/fecal sites. Bacteroidetes, Firmicutes, and Epsilonbacteraeota were the most abundant bacterial phyla present in the GI tract and feces based on mean taxonomic composition with high variation of composition found in the stomach. In the mycobiome, the dominant phyla were Ascomycota and Basidiomycota, and the stomach mycobiome did not demonstrate the same high level of variation observed in the bacteriome. Potential interactions between genera were found in the lower piglet GI bacteriome and mycobiome with positive correlations found between the fungus, Kazachstania, and several bacterial species, including Lactobacillus. Aspergillus demonstrated negative correlations with the short chain fatty acid-producing bacteria Butyricoccus, Subdoligranulum, and Fusicatenibacter. This study demonstrates the distinct colonization dynamics between fungi and bacteria in the GI tract and feces of piglets directly following weaning and the potential interactions of these microbes in the porcine gut ecosystem.
Phylogeographic analysis and identification of factors impacting the diffusion of Foot-and-Mouth disease virus in Africa

Foot and mouth disease (FMD) is endemic in sub-Saharan Africa and can lead to important and continuous economic losses for affected countries. Due to the complexity of the disease epidemiology and the lack of data there is a need to use inferential computational approaches to fill the gaps in our understanding of the circulation of FMD virus on this continent. Using a phylogeographic approach we reconstructed the circulation of FMD virus serotypes A, O and SAT2 in Africa and evaluated the influence of potential environmental and anthropological predictors of virus diffusion. Our results show that over the last hundred year the continental circulation of the tree serotypes was mainly driven by livestock trade. Whilst our analyses show that the serotypes A and O were introduced in Africa trough livestock trades, the SAT2 serotype probably originates from African wildlife population. The circulation of serotype O in eastern Africa is impacted by both indirect transmission through persistence in the environment and anthropological activities such as cattle movements.
Concurrent design of control software and configuration of hardware for robot swarms under economic constraints

Designing a robot swarm is challenging due to its self-organized and distributed nature: complex relations exist between the behavior of the individual robots and the collective behavior that results from their interactions. In this paper, we study the concurrent automatic design of control software and the automatic configuration of the hardware of robot swarms. We introduce Waffle, a new instance of the AutoMoDe family of automatic design methods that produces control software in the form of a probabilistic finite state machine, configures the robot hardware, and selects the number of robots in the swarm. We test Waffle under economic constraints on the total monetary budget available and on the battery capacity of each individual robot comprised in the swarm. Experimental results obtained via realistic computer-based simulation on three collective missions indicate that different missions require different hardware and software configuration, and that Waffle is able to produce effective and meaningful solutions under all the experimental conditions considered.
Brief Announcement: Massively Parallel Approximate Distance Sketches

Data structures that allow efficient distance estimation have been extensively studied both in centralized models and classical distributed models. We initiate their study in newer (and arguably more realistic) models of distributed computation: the Congested Clique model and the Massively Parallel Computation (MPC) model. In MPC we give two main results: an algorithm that constructs stretch/space optimal distance sketches but takes a (small) polynomial number of rounds, and an algorithm that constructs distance sketches with worse stretch but that only takes polylogarithmic rounds. Along the way, we show that other useful combinatorial structures can also be computed in MPC. In particular, one key component we use is an MPC construction of the hopsets of [2]. This result has additional applications such as the first polylogarithmic time algorithm for constant approximate single-source shortest paths for weighted graphs in the low memory MPC setting. 2012 ACM Subject Classification Theory of computation → Massively parallel algorithms
Pragmatic Language Skills: A Comparison of Children With Cochlear Implants and Children Without Hearing Loss

Pragmatic language ability refers to the ability to use language in a social context. It has been found to be correlated with success in general education for deaf and hard of hearing children. It is therefore of great importance to study why deaf and hard of hearing children often perform more poorly than their hearing peers on tests measuring pragmatic language ability. In the current study the Pragmatics Profile questionnaire from the CELF-IV battery was used to measure pragmatic language ability in children using cochlear implants (N = 14) and children without a hearing loss (N = 34). No significant difference was found between the children with cochlear implants (CI) and the children without hearing loss (HL) for the sum score of the pragmatics language measure. However, 35.71% of the children with CI performed below age norm, while only 5.89% of the children without HL performed below age norm. In addition, when dividing the sum score into three sub-measures: Rituals and Conversational skills (RCS), Asking for, Giving, and Responding to Information (AGRI), and Nonverbal Communication skills (NCS), significant differences between the groups were found for the NCS measure and a tendency for a difference was found for the RCS measure. In addition, all three sub-measures (NCS, AGRI, RCS) were correlated to verbal fluency in the children with CI, but not the children without HL.
Microbial Metabolic Capacity for Intestinal Folate Production and Modulation of Host Folate Receptors

Microbial metabolites, including B complex vitamins contribute to diverse aspects of human health. Folate, or vitamin B9, refers to a broad category of biomolecules that include pterin, para-aminobenzoic acid (pABA), and glutamate subunits. Folates are required for DNA synthesis and epigenetic regulation. In addition to dietary nutrients, the gut microbiota has been recognized as a source of B complex vitamins, including folate. This study evaluated the predicted folate synthesis capabilities in the genomes of human commensal microbes identified in the Human Microbiome Project and folate production by representative strains of six human intestinal bacterial phyla. Bacterial folate synthesis genes were ubiquitous across 512 gastrointestinal reference genomes with 13% of the genomes containing all genes required for complete de novo folate synthesis. An additional 39% of the genomes had the genetic capacity to synthesize folates in the presence of pABA, an upstream intermediate that can be obtained through diet or from other intestinal microbes. Bacterial folate synthesis was assessed during exponential and stationary phase growth through the evaluation of expression of select folate synthesis genes, quantification of total folate production, and analysis of folate polyglutamylation. Increased expression of key folate synthesis genes was apparent in exponential phase, and increased folate polyglutamylation occurred during late stationary phase. Of the folate producers, we focused on the commensal Lactobacillus reuteri to examine host–microbe interactions in relation to folate and examined folate receptors in the physiologically relevant human enteroid model. RNAseq data revealed segment-specific folate receptor distribution. Treatment of human colonoid monolayers with conditioned media (CM) from wild-type L. reuteri did not influence the expression of key folate transporters proton-coupled folate transporter (PCFT) or reduced folate carrier (RFC). However, CM from L. reuteri containing a site-specific inactivation of the folC gene, which prevents the bacteria from synthesizing a polyglutamate tail on folate, significantly upregulated RFC expression. No effects were observed using L. reuteri with a site inactivation of folC2, which results in no folate production. This work sheds light on the contributions of microbial folate to overall folate status and mammalian host metabolism.
Microbiome Big-Data Mining and Applications Using Single-Cell Technologies and Metagenomics Approaches Toward Precision Medicine

With the development of high-throughput sequencing technologies as well as various bioinformatics analytic tools, microbiome is not a “microbial dark matter” anymore. In this review, we first summarized the current analytical strategies used for big-data mining such as single-cell sequencing and metagenomics. We then provided insights into the integration of these strategies, showing significant advantages in fully describing microbiome from multiple aspects. Moreover, we discussed the correlation between gut microbiome with host organs and diseases, confirming the importance of big-data mining in clinical practices. We finally proposed new ideas about the trend of big-data mining in microbiome using multi-omics approaches and single-cell sequencing. The integration of multi-omics approaches and single-cell sequencing can provide full understanding of microbiome at both macroscopic level and microscopic level, thus contributing to precision medicine.
Visual Exploration of Dynamic or Static Joint Attention Bids in Children With Autism Syndrome Disorder

Eye-tracking studies have revealed a specific visual exploration style characterizing individuals with autism spectrum disorder (ASD). The aim of this study is to investigate the impact of stimulus type (static vs. dynamic) on visual exploration in children with ASD. Twenty-eight children with ASD, 28 children matched for developmental communication age, and 28 children matched for chronological age watched a video and a series of photos involving the same joint attention scene. For each stimulus, areas of interest (AOI) were determined based on Voronoi diagrams, which were defined around participants' fixation densities, defined by the mean shift algorithm. To analyze the eye-tracking data on visual exploration, we used a method for creating AOI a posteriori, based on participants' actual fixations. The results showed the value of both kinds of stimuli. The photos allowed for the identification of more precise AOI and showed similarities in exploration between ASD and typical children. On the other hand, video revealed that, among ASD children only, there are few differences in the way they look at the target depending on the deictic cue used. This raises questions regarding their understanding of a joint attention bid recorded on a video. Finally, whatever the stimulus, pointing seems to be the most important element for children looking at the target.
Exploration of multicore systems based on silicon integrated communication networks

More computing cores are now being integrated on a single chip in order to meet the ever-growing application demands for high performance and low power computing systems. As the number of cores continues to grow, so is the demand for scalable on-chip communication networks that can deliver high-speed communication among the cores. Contrary to traditional on-chip networks, Networks-on-Chip(NoCs) have emerged as a mature alternative interconnect for manycore architectures since it provides enhanced scalability and power efficiency. Typical NoC routers consist of buffers which serve as temporary data storage. However, studies have shown that buffers are often unutilized (i.e. idle or underutilized) especially when executing applications with non-uniform traffic patterns or bursty behaviours. This is because most typical routers dedicate a set of buffers to their input and/or output ports and these buffers can only be exploited by dataflows using them, which leads to significant performance degradation. Therefore, router architectures capable of maximizing buffer utilization for performance gains are indispensable. In order to maximize buffer resource utilization, this thesis proposes a novel NoC router concept called Roundabout NoC (R-NoC) that is inspired by real-life multi-lanes traffic roundabout. Contrary to existing approaches, R-NoC provides intrinsic and effective resource utilization. However, roundabout-inspired routers are susceptible to deadlocks due to their ring-like architecture. Contrary to existing solutions, R-NoC achieves deadlock-freeness and enhanced network performance over typical NoCs without compromising network area/power. This thesis further exploits R-NoC highly parametric architecture in order to produce different router configurations with varying topological trade-offs for performance gains without sacrificing area.
N-Propyl-N-Methylpyrrolidinium Difluoro(oxalato)borate as a Novel Electrolyte for High-Voltage Supercapacitor

Development of high voltage electrolyte is one of the effective ways to improve the performance of supercapacitor. The new ionic liquid N-propyl-N-methylpyrrolidinium difluoro(oxalato)borate (Py13DFOB) was designed and mixed with propylene carbonate (PC) as electrolyte for supercapacitor. The operating voltage of the new electrolyte system has been proven to be up to 3.0 V by a series of electrochemical techniques. Surprisingly, the new salt exhibits nearly symmetric capacitance contribution in the positive and negative electrodes, leading to a high capacitance value of 130 F g−1. The energy and power density of EDLCs using Py13DFOB in the PC electrolyte reach 39.06 Wh kg−1 (100 mA g−1) and 8.03 kW kg−1 (5,000 mA g−1), respectively, at the working voltage of 3.0 V, significantly exceeding the performance of commercial electrolyte tetraethylammonium tetrafluoroborate (TEABF4). The results indicate that Py13DFOB can be a promising electrolyte salt for supercapacitor.
Effects of High-Intensity Interval Training and Isoinertial Training on Leg Extensors Muscle Function, Structure, and Intermuscular Adipose Tissue in Older Adults

We compared the effects of aerobic high-intensity training (HIT) and isoinertial resistance training (IRT) on the strength, mass, architecture, intermuscular adipose tissue (IMAT) quality, and neuromuscular activation of the quadriceps in elderly subjects. Twelve healthy men (69.3 ± 4.2 years; 77.8 ± 10.4 kg; 1.72 ± 0.05 m) were exposed to 8 weeks of HIT (7 × 2-min cycling repetitions at 90% of V.O2peak, 3 times/week) and, after 4 months (detraining), to IRT (4 × 7 maximal concentric–eccentric knee extensions, 3 times/week). Before and after trainings, we measured knee extension isometric (TMVC) and dynamic (TC) maximal concentric torque, anatomical cross-sectional area (ACSA) at 25, 50, and 75% of femur length, quadriceps volume (Vol), IMAT, pennation angle (θp) of the fibers from the vastus lateralis, and voluntary activation (%Act). TMVC and TC were significantly larger only after IRT (P = 0.008); IRT was able to elicit a greater increase of ACSA than HIT; Vol increases similarly and significantly after HIT and IRT (P = 0.003–0.001); IMAT at 50% of femur length decreased after both HIT and IRT (P = 0.001–0.003); physiological cross-sectional area (PCSA) was larger after IRT than before (P = 0.025); specific torque did not change throughout the study (45.5 N cm–2 ± 12.0); %Act of the quadriceps was significantly affected only by IRT (P = 0.011). Both HIT and IRT are able to elicit beneficial modifications of muscular mass, architecture, and quality (reducing IMAT) in elderly subjects in connection with an amelioration of strength. HIT and IRT caused a homogeneous increase of ACSA and of Vol of the quadriceps. PCSA increases, but specific strength per unit of PCSA did not change. The increases of functional torque seemed to be attributed to a parallel increase of %Act and muscle hypertrophy only after IRT. Data suggest that IMAT may be a prominent indicator to track metabolic-dependent activity and skeletal muscle quality.
The Complexity of Symmetry Breaking in Massive Graphs

The goal of this paper is to understand the complexity of symmetry breaking problems, specifically maximal independent set (MIS) and the closely related $\beta$-ruling set problem, in two computational models suited for large-scale graph processing, namely the $k$-machine model and the graph streaming model. We present a number of results. For MIS in the $k$-machine model, we improve the $\tilde{O}(m/k^2 + \Delta/k)$-round upper bound of Klauck et al. (SODA 2015) by presenting an $\tilde{O}(m/k^2)$-round algorithm. We also present an $\tilde{\Omega}(n/k^2)$ round lower bound for MIS, the first lower bound for a symmetry breaking problem in the $k$-machine model. For $\beta$-ruling sets, we use hierarchical sampling to obtain more efficient algorithms in the $k$-machine model and also in the graph streaming model. More specifically, we obtain a $k$-machine algorithm that runs in $\tilde{O}(\beta n\Delta^{1/\beta}/k^2)$ rounds and, by using a similar hierarchical sampling technique, we obtain one-pass algorithms for both insertion-only and insertion-deletion streams that use $O(\beta \cdot n^{1+1/2^{\beta-1}})$ space. The latter result establishes a clear separation between MIS, which is known to require $\Omega(n^2)$ space (Cormode et al., ICALP 2019), and $\beta$-ruling sets, even for $\beta = 2$. Finally, we present an even faster 2-ruling set algorithm in the $k$-machine model, one that runs in $\tilde{O}(n/k^{2-\epsilon} + k^{1-\epsilon})$ rounds for any $\epsilon$, $0 \le \epsilon \le 1$.
Premorbid Alterations of Spontaneous Brain Activity in Elderly Patients With Early Post-operative Cognitive Dysfunction: A Pilot Resting-State Functional MRI Study

Background: Elderly patients with pre-existing cognitive impairment are susceptible to post-operative cognitive dysfunction (POCD). In this study, we investigated whether there is pre-existing local homogeneity and functional connectivity alteration in the brain before surgery for POCD patients as compared to that in non-POCD patients. Methods: Eighty elderly patients undergoing major thoracic or abdominal surgeries were recruited. Resting-state functional MRI was scanned at least 1 day before surgery. Neuropsychological tests (NPTs) were performed before surgery and at discharge, respectively. Pre-operative regional homogeneity (ReHo) and resting-state functional connectivity (RSFC) were compared between POCD patients and non-POCD patients, respectively. Partial correlation between NPTs and ReHo or RSFC was analyzed by adjusting for confounding factors. Results: Significant difference (P < 0.001, Gaussian Random Field (GRF) correction which is a multiple comparisons correction method at cluster level, cluster size > 49) in ReHo between POCD patients and non-POCD patients was detected in right hippocampus/parahippocampus. Pre-operative RSFC between right hippocampus/parahippocampus and right middle/inferior temporal gyrus increased in POCD patients (P < 0.001, GRF correction for multiple comparisons) when compared with that in non-POCD patients.RSFC significantly correlated with composite Z-score (r = 0.46, 95% CI [0.234, 0.767], P = 0.002) or Digit Symbol Substitution Test Z-scores (r = 0.31, 95% CI [0.068, 0.643], P = 0.046) after adjusting for confounding factors. Conclusions: The results suggest that premorbid alterations of spontaneous brain activity might exist in elderly patients who develop early POCD. The neural mechanism by which patients with pre-operative abnormal spontaneous activity are susceptible to POCD requires further study.