Miracle-dz/UniFAR-FTUs huggingface dataset:
HSF2 protects against proteotoxicity by maintaining cell-cell adhesion

Cellular ability to maintain proper protein homeostasis (proteostasis) is essential for survival upon protein-damaging conditions. Heat shock transcription factor 2 (HSF2) is one of the human HSFs activated in response to proteotoxic stress. HSF2 is dispensable for cell survival during acute heat stress, but its amount and DNA-binding activity increase under prolonged proteotoxic stress conditions, such as proteasome inhibition. Nevertheless, the specific role(s) of HSF2 and the global HSF2-dependent gene expression profile during sustained stress have remained elusive. We found that HSF2 is required for cell survival during prolonged proteotoxicity, as shown by treating wild-type and HSF2-deficient human osteosarcoma U2OS cells with the proteasome inhibitor Bortezomib. Strikingly, our RNA-seq analyses revealed that HSF2 disruption leads to marked downregulation of cadherin superfamily genes and subsequent functional impairment of cadherin-mediated cell-cell adhesion. We propose HSF2 as a key regulator of genes belonging to the cadherin superfamily. We also demonstrate that HSF2-dependent downregulation of cadherin-mediated cell-cell adhesion predisposes U2OS cells to Bortezomib-induced proteotoxic stress. In conclusion, we show that by maintaining cell-cell adhesion HSF2 is essential for cell survival and thereby we describe a novel regime in the HSF-mediated protection against stress-induced protein damage.
Reproductive & Biomarker Response to a Daily Dose of Instant Noodle Seasoning in Male Albino Rats (Rattus norvegicus)

The effect of a daily consumption of Instant noodle seasoning containing the Monosodium glutamate (MSG) on rat was evaluated, The parameters investigated include; Alkaline aminotransferase (ALT), Aspartate aminotransferase (AST). Hemoglobin (Hb), packed cell volume (PCV) white blood cell (WBC), protein, platelets, lymphocytes and Serum electrolytes; sodium (Na+), potassium (K+) chloride (Cl), bicarbonate (HCO3 - ). Sperm count was also investigated. The results revealed the following, the mean PCV was 29 and 25.13on week 1 and week 4, with an average control of 30.69, mean Hb was 10 in week 1 and 6.57 in week 4, RBC had an average control of 5.28 while week 1 had a mean of 4.77 and week 4 3.67, there was a significant difference (P<0.05) for PCV and Hb. The mean WBC and Lymphocyte were 6 and 61 in the first week, and 5.8 and 60.17 on the fourth week, with an average control of 5.28 for WBC and 77.53 for lymphocytes. Platelet had a mean of 251 on the first week and a mean of 532 on the fourth week with a significant difference across the group in WBC and platelets (P<0.05). The mean serum Na, K and Cl reduced from 140.67, 4.13 and 100.67 in week 1 to 116, 2.5 and 98 in week 4 with a significant difference (P<0.05) across the group when compared to the average control for Na and K. HCO3 had a mean of 23.67 in week 1 and a mean of 22.67 in week 4 in the treated group. AST had a mean of 24 in week 1 which increased to 41.67 in week 4 while ALT increased from a mean of 4.00 in week 1 and 28 in week 4 with a significant difference (P<0.05) across the group. The mean serum protein was 51.93 in week 1 and a 74.29 in week 4. The mean sperm count was 800, 299.67, 450.67 and 501 for week 1, 2, 3 and 4 respectively. The results indicates that daily consumption of Instant noodle seasoning may cause liver damage, and kidney dysfunction and has been discovered to have negative effects on blood and sperm cells.
Malignant phyllodes tumors of the breast associating malignancy of both mesenchymal and epithelial components (invasive or in situ ductal carcinoma)

Phyllodes tumors of the breast are biphasic tumors consisting from an epithelial component and a mesenchymal component. Usually, the mesenchymal component of the tumor is the one who dictates the malignancy of the biphasic proliferation. Presence of the malignancy of the both, epithelial [under the form of invasive carcinoma or ductal carcinoma in situ (DCIS)] and mesenchymal components is very rare. Most of the data available from the literature refers to single case presentations. This paper presents the experience of Prof. Dr. Ion Chiricuţă Oncological Institute (IOCN), Cluj-Napoca, Romania, with the malignant phyllodes tumors with both epithelial and mesenchymal components showing malignancy. Over two decades (1999–2018), four cases of malignant phyllodes tumors with concomitant epithelial and mesenchymal malignancy were found and presented as a case series. Two out of four cases were malignant phyllodes tumors harboring invasive breast carcinomas (one case with associated DCIS and one case of pure invasive carcinoma) and two cases were malignant phyllodes tumors with the epithelial component showing DCIS. Average follow-up period was 67 months (from 39 to 132 months) with a disease-free survival of 58 months.
The complete chloroplast genome of Atraphaxis jrtyschensis (polygonaceae), an endemic and endangered desert shrub to Xinjiang, China

Abstract Atraphaxis jrtyschensis (Polygonacae) is an endangered desert shrub endemic to China in Xinjiang province with great ecological importance for sand fixation. However, its genomic resources are still very limited. Here, we generated the first chloroplast (cp) genome of A. jrtyschensis using genome skimming sequencing. The whole cp genome is 164,192 bp and comprises 130 genes, including 83 protein-coding genes, 37 tRNA genes, 8 rRNA genes, and 2 pseudogenes (rpl23). The overall GC content of A. jrtyschensis cp genome is 37.5%. The phylogenic analysis placed A. jrtyschensis at the base of Trib Rumiceae, which contained the genera Rheum and Oxyria. This study will be useful for future researches to investigate the conservation genetics and potential applications in sand fixation of the endangered desert shrub.
Kegel Exercise and Duloxetine Hydrochloride for management of Stress Urinary Incontinence (SUI)

Introduction: Stress Urinary Incontinence (SUI) affects the quality of life of at least one third of women globally. This problem is more common in India, where women usually do not seek treatment for their reproductive health problems and do not vocalize their symptoms. Kegel exercise and Duloxetine are said to be effective for the management of SUI. Hence it was tried to see the effects of these methods in the population of Jhalawar, Rajasthan. Materials and Method: A total of 80 females having Stress Incontinence were included in the study and 40 women were advised Kegel exercises and remaining were prescribed kegel exercises along with Duloxetine for 8 weeks. After 8 weeks they were evaluated for their symptoms. Results: Statistically significant improvement was observed after Kegel exercises alone and with combined Duloxetine and Kegel exercises but more improvement was seen when Duloxetine was added to Kegel exercises. Conclusion: It can be concluded that Duloxetine along with Kegel exercises is more effective for controlling SUI in the study population as compared to kegel exercises alone.
3D experimental investigation of the hygro-mechanical behaviour of wood at cellular and sub-cellular scales

Many biological and engineering materials present a cellular structure, which provides them low density, high strength and high toughness. An exhaustive experimental and analytical investigation is carried out in this work in order to understand the response of these materials to environmental stimuli. This step is important in the context of evaluating their durability in different loading conditions. The focus is on softwood but the approach can be applied to other cellular materials. Wood is hygromorphic, responding to changes in environmental humidity by changing its geometry. The complex hierarchical structure of wood tends to deform during moisture sorption. The origin of the moisture induced deformation lies at the cellular and subcellular scales. High-resolution microand nanoX-ray tomography, combined with advanced tools for image analysis, are utilized to devise a solid non-destructive approach for the estimation of the swelling behaviour of softwood. Starting from the cellular scale, new findings in the anisotropic and reversible swelling behaviour of softwood and in the origin of swelling hysteresis in porous materials are explained from a mechanical perspective. Swelling due to moisture sorption displays also a non-affine component. A new sophisticated mathematical method for detecting locally the non-affine deformations in the cellular structure is presented in this work. The results highlight that the mechanical and moisture properties of wood highly depend on sub-cellular features of the wood cell wall. The experimental and analytical approach proposed in this thesis develops a line of research bridging the gap from sub-cellular to macroscale in cellular materials.
A Comparative Study to Explore the Effect of Different Compounds in Immune Proteins of Human Beings Against Tuberculosis: An In-silico Approach

The lungs are directly exposed to pollutants, pathogens, allergens, and chemicals, which might lead to physiological disorders. During the Bhopal gas disaster, the lungs of the victims were exposed to various chemicals. Here, using molecular modelling studies, we describe the effects of these chemicals (Dimethyl urea, Trimethyl urea, Trimethyl isocyanurate, Alphanaphthol, Butylated hydroxytoluene and Carbaryl) on pulmonary immune proteins. In the current study, we performed molecular modelling methods like molecular docking and molecular dynamics simulation studies to identify the effects of hydrolytic products of MIC and dumped residues on the pulmonary immune proteins. Molecular docking studies of (Dimethyl urea, Trimethyl urea, Trimethyl isocyanurate, Alphanaphthol, Butylated hydroxytoluene and Carbaryl) on pulmonary immune proteins was performed using the Autodock 4.0 tool, and gromacs was used for the molecular dynamics simulation studies to get an insight into the possible mode of protein-ligand interactions. Further, in silico ADMET studies was performed using the TOPKAT protocol of discovery studio. From docking studies, we found that surfactant protein-D is inhibited most by the chemicals alphanaphthol (dock score, -5.41Kcal/mole), butylated hydroxytoluene (dock score,-6.86 Kcal/mole), and carbaryl (dock score,-6.1 Kcal/mole). To test their stability, the obtained dock poses were placed in a lipid bilayer model system mimicking the pulmonary surface. Molecular dynamics simulations suggest a stable interaction between surfactant protein-D and carbaryl. This, study concludes that functioning of surfactant protein-D is directly or indirectly affected by the carbaryl chemical, which might account for the increased susceptibility of Bhopal gas disaster survivors to pulmonary tuberculosis.
The Interatheriinae (Mammalia, Notoungulata) of the Friasian sensu stricto and Mayoan (middle to late Miocene), and the fossils from Cerro Zeballos, Patagonia, Argentina

The middle to late Miocene Friasian sensu stricto, Colloncuran and Mayoan South American Land Mammal Ages (SALMAs) were established based on the mammals recovered from the Río Frías, Collón Curá and Río Mayo formations, respectively (southern Argentina and Chile). Records of Interatheriinae (Notoungulata) from these sediments have been known since the first contributions of Ameghino and Roth, but most of this material has only been superficially revised or is almost unstudied. Based on these old collections and new interatheriine records from Cerro Zeballos (Chubut Province), we improve the diagnosis of Caenophilus tripartitus, describe new and peculiar characters for this taxon, consider Epipatriarchus bifidens as Protypotherium cf. colloncurensis, and propose Epipatriarchus as a junior synonym of Protypotherium. In turn, the holotype of Epipatriarchus innexus is here identified as the mesotheriid Trachytypotherium sp. Therefore, only two genera of Interatheriinae, Protypotherium and Caenophilus, are recognized in the Friasian sensu stricto and Mayoan. We identify Protypotherium cf. endiadys and a probable new species of Protypotherium for the Friasian sensu stricto, P. cf. colloncurensis and Caenophilus tripartitus for the Mayoan, and C. tripartitus, P. colloncurensis and P. cf. endiadys for Cerro Zeballos. An extended phylogenetic analysis is performed, including species from low latitudes and new data for P. colloncurensis and Caenophilus tripartitus, with the latter recovered as a sister taxon to Miocochilius federicoi. Both Protypotherium and Miocochilius are recovered as paraphyletic. The updated information we present provides a better knowledge of Interatheriinae for the middle to late Miocene of southern South America.
USE OF BIOMETRICS TO DETERMINE BIOCHEMISTRY KNOWLEDGE LEVEL DIFFERENCES IN READING AND PROCESSING METABOLIC PATHWAYS

USE OF BIOMETRICS TO DETERMINE BIOCHEMISTRY KNOWLEDGE LEVEL DIFFERENCES IN READING AND PROCESSING METABOLIC PATHWAYS By Kimberly D. Kammerdiener The areas of chemistry and biochemistry commonly use external representations to enhance learning for students. The use of schematics and representations for illustrating metabolic pathways is a familiar image in most biochemistry textbooks. These external representations can be the key to student understanding. To date, there has not been any previous research specifically focused on the areas of interest that are predominant for an individual viewing a metabolic pathway commonly found in a biochemistry textbook. Therefore, this thesis study set out to 1) investigate what individuals look at in a metabolic pathway based on their level of expertise in metabolism and 2) to look at areas of brain activation during the time an individual is viewing a metabolic pathway based on their level of expertise in metabolism. This was a phenomenological study; however, multiple theoretical frameworks guided the development, collection, and analysis of the data in this study. The method used to collect the data included manually co-registered systems of eyetracking and electroencephalograph (EEG) followed by separate analysis. The experiment was conducted using 45 participants with varying levels of expertise in biochemistry. Through a postsurvey, the participants were found to have different levels of familiarity with the metabolic pathways used for the stimulus presentation. This research concentrated on determining what part of the image the participants focused on and tracked the path that participants took while viewing metabolic pathway representations. This was accomplished through the use of an eyetracking system that mapped the movement of the participants' eyes while engaged with the
Etude des potentialités des ciments sulfo-alumineux bélitiques pour le conditionnement du zinc De l'hydratation à la durabilité

Les ciments silico-calciques sont largement utilises pour le conditionnement des dechets nucleaires de faible activite. Cependant, les interactions existant entre certains constituants du dechet et les phases cimentaires peuvent perturber l'hydratation de ces dernieres. Ainsi, le zinc ZnII, frequemment rencontre sous forme de sel chlore dans les cendres d'incineration de dechets alpha contenant du PVC ou du neoprene, est connu pour inhiber la prise du ciment Portland. Une solution a ce probleme serait d'utiliser un liant de chimie differente, qui presenterait une meilleure compatibilite avec le dechet a conditionner tout en conservant les qualites d'une matrice cimentaire (cout modeste, mise en oeuvre aisee, hydratation avec l'eau apportee par les dechets.). Le potentiel des ciments sulfo-alumineux belitiques pour le conditionnement du zinc ZnII a donc ete evalue. Quatre aspects ont ete abordes : le deroulement de l'hydratation, les proprietes des liants hydrates, les mecanismes assurant la retention du zinc et la durabilite des materiaux obtenus (lixiviation et modelisation a l'aide d'un code de transport reactif). Les influences du dosage en gypse, de l'echauffement induit par l'hydratation de pieces massives, et de la teneur en chlorure de zinc ont ete determinees. Il en resulte que les materiaux a base de ciment sulfo-alumineux gypse a hauteur de 20 % sont de bons candidats pour le conditionnement du zinc : pas de retard d'hydratation, assemblage mineralogique robuste vis-a-vis de la temperature (dans la gamme 20 - 85°C), bonne resistance mecanique, stabilite dimensionnelle et tres bonne retention du zinc, meme lors d'une lixiviation prolongee par l'eau pure.
Cell suspension culture as a means to produce polyphenols from date palm (Phoenix dactylifera L.)

ABSTRACT Date palm accumulates a wide range of secondary metabolites high in nutritional and therapeutic value. In the present study, date palm (Phoenix dactylifera L., cv. Shaishi) shoot-tip-induced callus was used to establish cell suspension cultures in Murashige and Skoog (MS) liquid medium containing 1.5 mg L-1 2-isopentenyladenine (2iP) and 10 mg L-1 naphthaleneacetic acid (NAA). To study the growth kinetics, cultures were maintained for 12 weeks during which weekly measurements were carried out to determine the biomass accumulation based on packed cell volume (%), fresh weight and dry weight (g). In addition, weekly determination of polyphenols (catechin, caffeic acid, kaempferol, and apigenin) was carried out using high performance liquid chromatography (HPLC). The 11-week-old culture was found highest in the production of biomass (62.9 g L-1 fresh weight and 7.6 g L-1 dry weight) and polyphenols (catechin-155.9 µg L-1, caffeic acid-162.7 µg L-1, kaempferol-89.7 µg L-1, and apigenin-242.7 µg L-1) from the cell suspension cultures. This is the first report on the production of polyphenols from the cell suspension culture of date palm. This study facilitates further development of large-scale production of polyphenols and the utilization of bioreactors.
Conceptualizing the development of personality in children: An analysis of Islamic philosophy and contemporary Western psychology

The paper aims to examine the concept of child personality development from the perspectives of Islamic philosophy and contemporary Western psychology. In recent decades, the parental journey associated with the healthy development of children has become increasingly complex and sometimes stressful across all societies and communities of the world. Major world religions and social sciences delineated various aspects and perspectives relating to sound personality development in children. The present article seeks to present the findings of a study that found to give an overview of fundamental principles related to child personality development drawn from Islamic philosophy and contemporary Western psychology. Drawing on these two perspectives, the paper seeks to explain personality development, highlighting both similarities and differences associated with these perspectives. The study employed qualitative content analysis to explore relevant data from the Qur’anic verses and Prophetic traditions, as well as theoretical studies and empirical research of psychology. The research findings predominantly highlight an integrated approach towards child personality development as framed within the perspective of Islamic philosophy and contemporary Western psychological understandings. The paper serves to link Islamic thought to contemporary Western psychological aspects as a means of highlighting the utility of religious wisdom to predominant Western constructs of child development.
NOMA-Based Pervasive Edge Computing: Secure Power Allocation for IoV

Nowadays, intelligent transportation industry is becoming a hot spot in Internet of vehicles (IoV). However, owing to the existence of numerous intelligent terminals, communication security becomes a pressing problem. On the other hand, pervasive edge computing (PEC), as a pivotal technology, can significantly improve the performance of the system compared to the traditional cloud computing. In this article, we propose a nonorthogonal multiple access (NOMA)-based PEC power allocation framework in IoV, aiming at minimizing the system latency in the presence of eavesdroppers. Besides, queuing models, imperfect channel state information, and vehicles’ speeds are all considered. Since the formulated problem is complicated, we consider its lower bound and derive the suboptimal closed-form expressions of the power allocation coefficients. Furthermore, a Frank-and-Wold algorithm is proposed to achieve the optimum total power. Simulation results illustrate the superior performance of the proposed NOMA scheme.
Investigation of Protective Effect of Matricaria Chamomilla L. Extract on Methotrexate-Induced Hepatotoxicity in Wistar Rat

Methotrexate (MTX) was shown to cause oxidative stress and liver damage. The objective was to investigate the possible protective effects of Matricaria Chamomilla L. (chamomile) extract with anti-oxidant and anti-inflammatory properties on the methotrexate-induced liver toxicity. Twenty four Wistar rats were divided into four groups. MTX group was injected intraperitoneally on days 7 and 14 with 20 mg/kg methotrexate. Groups CE200 (chamomile extract 200 mg/kg/day) and CE300 (chamomile extract 300 mg/kg/day) received the same dose of methotrexate added with chamomile extract orally for 15 days at 200 mg/kg and 300 mg/kg respectively and the last group was healthy control group. Results of biochemical analyses indicated serum liver biomarkers (aminotransferases), alkaline phosphatase (ALP), albumin, and liver content of anti-oxidant enzymes (catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px)), reduced glutathione (GSH) and total anti-oxidant capacity (TAC) significantly increased (P <0.050.001) to normal in the CE treated groups compared to those of the MTX group. Serum bilirubin and hepatic malondialdehyde (MDA) levels significantly increased (P ˂0.001) in MTX group compared to those of the control group and decreased in CE200 and CE300 groups compared to those of the MTX group. Histopathological study showed inflammatory damage, necrotic cells and lipid infiltration in MTX group. In the groups treated with the chamomile extract, a significant improvement was observed in liver tissue in response HIGHLIGHTS  The chamomile extract improved MTX-induced liver histopathological and biochemical changes.  The improvement was significant in the rats that were treated with higher dose of extract (CE300).  The extract enhanced anti-oxidant defense system and decreased MTX-induced oxidative damage. 2 Soltani, M. ; et al. Brazilian Archives of Biology and Technology. Vol.63: e20180626, 2020 www.scielo. br/babt to increased dose of the extract. In conclusion, chamomile extract administration could have a protective role in methotrexate-induced liver toxicity in rats through improving anti-oxidant defense system.