Miracle-dz/UniFAR-FTUs huggingface dataset:
Energy-efficient VLSI architectures for real-time and 3D video processing

Multiview autostereoscopic displays (MADs) make it possible to view video content in 3D without wearing special glasses, and such displays have recently become available. The main problem of MADs is that they require several (typically 8 or 9) views, while most of the 3D video content is in stereoscopic 3D today. To bridge this content-display gap, the research community started to devise automatic multiview synthesis (MVS) methods. Common MVS methods are based on depth-image-based rendering, where a dense depth map of the scene is used to reproject the image to new viewpoints. Although physically correct, this approach requires accurate depth maps and additional in-painting steps. Our work uses an alternative conversion concept based on image domain warping (IDW) which has been successfully applied to related problems such as aspect ratio retargeting for streaming video, and disparity remapping for depth adjustments in stereoscopic 3D content. IDW shows promising performance in this context as it only requires robust, sparse point-correspondences and no inpainting steps. However, MVS, using IDW as well as alternative approaches, is computationally demanding and requires real-time processing – yet such methods should be portable to end-user and even mobile devices to develop their full potential. To this end, this thesis investigates eﬃcient algorithms and hardware architectures for a variety of sub-problems arising in the MVS pipeline. We begin by evaluating binary descriptors for identifying corresponding points in rectiﬁed stereo settings, followed by the design of a complete feature extraction and matching system. The system employs the SKB descriptor and distinguishes by a high matching accuracy and descriptor throughput. For other settings with more general viewing conditions typically arising in applications such as optical ﬂow estimation, we design a new binary feature descriptor termed BOOM which signiﬁcantly outperforms state-of-the-art des-criptors. This descriptor is used to signiﬁcantly accelerate a recent patch match method to eﬃciently calculate optical ﬂow vectors.
Acute Mitral Regurgitation of Unknown Etiology Associated with Disseminated Intravascular Coagulation Eventually Diagnosed as Enterococcus Faecalis Infective Endocarditis by Mitral Valve Surgery

Patient: Female, 70 Final Diagnosis: Infective endocarditis Symptoms: Dyspnea Medication: — Clinical Procedure: — Specialty: Cradiology Objective: Challenging differential diagnosis Background: Infective endocarditis is prevalent worldwide and the modified Duke criteria have been used universally to diagnose this condition. However, making the correct diagnosis is rather difficult because the clinical presentation and findings of blood tests are non-specific. Case Report: A 70-year-old female complaining of dyspnea for 5 days with acute mitral regurgitation was transferred to our hospital. She had acute heart and respiratory failure and disseminated intravascular coagulation. Although infective endocarditis was suspected, repeated blood cultures and transesophageal echocardiography could not reveal any findings of infective endocarditis. Because the etiology of her condition was not determined by various examinations, mitral annuloplasty was required to treat her mitral regurgitation, and was performed for definitive diagnosis and treatment revealing the presence of vegetation on the mitral valve. Enterococcus faecalis was detected by cultures of the mitral valve and blood after the surgery. Conclusions: It can be very difficult to diagnose infective endocarditis correctly, especially when a case fails to fulfill the modified Duke criteria. In such a case, only cardiac surgery might enable us to make an accurate diagnosis and save a patient’s life.
Instruments to Measure Outcomes in Pediatric Palliative Care: A Systematic Review

In this systematic review, we critically appraise instruments used to measure the outcomes of palliative care interventions. CONTEXT: Pediatric palliative care (PPC) is intended to promote children’s quality of life by using a family-centered approach. However, the measurement of this multidimensional outcome remains challenging. OBJECTIVE: To review the instruments used to assess the impact of PPC interventions. DATA SOURCES: Five databases (Embase, Scopus, The Cochrane Library, PsychInfo, Medline) were searched. STUDY SELECTION: Inclusion criteria were as follows: definition of PPC used; patients aged 0 to 18 years; diseases listed in the directory of life-limiting diseases; results based on empirical data; and combined descriptions of a PPC intervention, its outcomes, and a measurement instrument. DATA EXTRACTION: Full-text articles were assessed and data were extracted by 2 independent researchers, and each discrepancy was resolved through consensus. The quality of the studies was assessed by using the Standard Quality Assessment Criteria for Evaluating Primary Research Papers From a Variety of Fields checklist. RESULTS: Nineteen of 2150 articles met the eligibility criteria. Researchers in 15 used quantitative methods, and 9 were of moderate quality. Multidimensional outcomes included health-related quality of life, spiritual well-being, satisfaction with care and/or communication, perceived social support, and family involvement in treatment or place-of-care preferences. PPC interventions ranged from home-based to hospital and respite care. Only 15 instruments (of 23 reported) revealed some psychometric properties, and only 5 included patient-reported (child) outcome measures. LIMITATIONS: We had no access to the developmental process of the instruments used to present the underlying concepts that were underpinning the constructs. CONCLUSIONS: Data on the psychometric properties of instruments used to assess the impact of PPC interventions were scarce. Children are not systematically involved in reporting outcomes.
Characterization of longitudinal canal tissue in the acorn barnacle Amphibalanus amphitrite

The morphology and composition of tissue located within parietal shell canals of the barnacle Amphibalanus amphitrite are described. Longitudinal canal tissue nearly spans the length of side shell plates, terminating near the leading edge of the specimen basis in proximity to female reproductive tissue located throughout the peripheral sub-mantle region, i.e. mantle parenchyma. Microscopic examination of stained longitudinal canal sections reveal the presence of cell nuclei as well as an abundance of micron-sized spheroids staining positive for basic residues and lipids. Spheroids with the same staining profile are present extensively in ovarioles, particularly within oocytes which are readily identifiable at various developmental stages. Mass spectrometry analysis of longitudinal canal tissue compared to tissue collected from the mantle parenchyma reveals a nearly 50% overlap of the protein profile with the greatest number of sequence matches to vitellogenin, a glycolipoprotein playing a key role in vitellogenesis–yolk formation in developing oocytes. The morphological similarity and proximity to female reproductive tissue, combined with mass spectrometry of the two tissues, provides compelling evidence that one of several possible functions of longitudinal canal tissue is supporting the female reproductive system of A. amphitrite, thus expanding the understanding of the growth and development of this sessile marine organism.
Abortion-related care and the role of the midwife: a global perspective

Introduction The International Confederation of Midwives (ICM) represents 132 midwifery associations in 113 countries. The ICM disseminates the Essential Competencies for Basic Midwifery Practice (EC) that describes the global scope of midwifery practice. The basic (core) and expanded (additional or optional) role of midwives in providing abortion-related care services was first described in 2010. A literature review about three items that are particularly critical to access to abortion services was conducted. Findings that emerged in the recent 2016–2017 update study about these three items are presented. Methods A modified Delphi study was administered via the Internet in a series of three rounds. Thirty-seven statements of abortion-related knowledge and skill were presented. Results A total of 895 individuals participated. The total of respondents across all three rounds represented 90 of the 105 member countries at the time of the study. The role of midwives in providing comprehensive abortion care, including referral for abortion and provision of postabortion family planning, achieved the necessary 85% agreement to be designated as essential (basic) knowledge or skill for the global scope of midwifery practice. The provision of medication abortion and performance of manual vacuum aspiration abortion were designated as optional for midwives who wished to provide these services. Endorsement of these latter practices was highest in both Francophone and Anglophone regions of Africa, Asian Pacific countries, and countries at a lower state of economic development. Conclusion The role of midwives in provision of abortion-related care services was reaffirmed in the recent Delphi study to inform the update to the EC. The role of midwives as direct providers of medical and vacuum aspiration abortions was reaffirmed for those individual midwives who wish to obtain the requisite competency to provide those services, in jurisdictions where these services are legally authorized.
A Multi Criteria Assessment Method for Identifying Vulnerable Marine Ecosystems in the North-East Atlantic

In international fisheries management, scientific advice on the presence of ‘Vulnerable Marine Ecosystems’ (VMEs) per United Nations resolutions, has generally used qualitative assessments based on expert judgement of the occurrence of indicator taxa such as cold-water corals and sponges. Use of expert judgement alone can be criticised for inconsistency and sometimes a lack of transparency; therefore, development of robust and repeatable numeric methods to detect the presence of VMEs would be advantageous. Here, we present a multi-criteria assessment (MCA) method to evaluate how likely a given area of seafloor represents a VME. The MCA is a taxa-dependent spatial method that accounts for both the quantity and data quality available. This was applied to a database of records of VMEs built, held and compiled by the International Council for the Exploration of the Sea (ICES). A VME index was generated which ranged from 1.51 to 4.52, with 5.0 being reserved for confirmed VME habitats. An index of confidence was also computed that ranged from 0.0 to 0.75, with 1 being reserved for those confirmed VME habitats. Overall the MCA captured the important elements of the ICES VME database and provided a simplified, spatially aggregated and weighted estimate of how likely a given area is to contain VMEs. The associated estimate of confidence gave an indication of how uncertain that assessment was for the same given area. This methodology provides a more systematic and standardised approach for assessing the likelihood of presence of VMEs in the North-East Atlantic.
Food insecurity was associated with low quality diet and low HDL level in mothers of Northwest Mexico relying on fisheries for livelihood.

BACKGROUND food insecurity occurs when quality and quantity of food is insufficient for maintaining healthy nutritional and food profiles. OBJECTIVES to determine if food insecurity is associated with dietary and biochemical measures in mothers of the northwest of Mexico, which relies primarily on fisheries for livelihood. METHODS a cross-sectional study was conducted with 116 mothers of the Northwest of Mexico. A socioeconomic survey, food security scale, andtwo non-consecutive 24-hour recalls were applied. Anthropometric measurements were made and hemoglobin, glucose and cholesterol levelswere measured. The association between key measures and food insecurity was assessed using logistic and linear regression. RESULTS two-thirds (68%) of households experienced food insecurity. Mothers with mild insecurity had 3.7 and 3.2 times higher odds of not consuming fruits and vegetables, respectively, and 4.9 times higher odds of consuming sweetened non-dairy drinks (p = 0.04; 0.04 and 0.05, respectively). In addition, they consumed less protein (β = -3.22%; p < 0.01) and more carbohydrates (β = 6.04%; p = 0.02) compared with mothers with food security. Mothers with severe insecurity consumed less iodine (β = -24.41 μg; p = 0.03) and had lower levels of HDL cholesterol (β = -12.01 mg/dl; p = 0.03) than mothers with food security. CONCLUSIONS food insecurity was associated with low quality diet and low levels of HDL cholesterol in mothers of Northwest Mexico relying on fisheries for livelihood.
Genetic diversity of the enteroviruses detected from cerebrospinal fluid (CSF) samples of patients with suspected aseptic meningitis in northern West Bank, Palestine in 2017

Background Human enterovirus genus showed a wide range of genetic diversity. Objectives To investigate the genetic diversity of the enteroviruses isolated in 2017 in northern West Bank, Palestine. Study design 249 CSF samples from aseptic meningitis cases were investigated for HEV using two RT-PCR protocols targeting the 5’ NCR and the VP1 region of the HEV genome. The phylogenetic characterization of the sequenced VP1 region of Echovirus18 (E18) and Coxsackievirus B5 (CVB5) isolated in Palestine along with 27 E18 and 27 CVB5 sequences available from the Genbank were described. Results E18 and CVB5 account for 50% and 35% of the successfully HEV types, respectively. Phylogenetic tree of E18 and CVB5 showed three main clusters, with all Palestinian isolates uniquely clustering together with those from China and from different countries, respectively. Cluster I of E18, with 13 Palestinian and 6 Chinese isolates, showed the lowest haplotype-to-sequence ratio (0.6:1), haplotype diversity (Hd), nucleotide diversity (π), and number of segregating sites (S) compared to clusters II and III. Furthermore, cluster I showed negative Tajima’s D and Fu-Li’sF tests with statistically significant departure from neutrality (P<0.01). In both E18 and CVB5 populations, high haplotype diversity, but low genetic diversity was evident. Inter-population pairwise genetic distance (Fst) and gene flow (Nm) showed that the Palestinian E18 and CVB5 clusters were highly differentiated from the other clusters. Conclusions The study divulged close genetic relationship between Palestinian HEV strains as confirmed by population genetics and phylogenetic analyses.
Folic acid contributes to peripheral nerve injury repair by promoting Schwann cell proliferation, migration, and secretion of nerve growth factor

After peripheral nerve injury, intraperitoneal injection of folic acid improves axon quantity, increases axon density and improves electromyography results. However, the mechanisms for this remain unclear. This study explored whether folic acid promotes peripheral nerve injury repair by affecting Schwann cell function. Primary Schwann cells were obtained from rats by in vitro separation and culture. Cell proliferation, assayed using the Cell Counting Kit-8 assay, was higher in cells cultured for 72 hours with 100 mg/L folic acid compared with the control group. Cell proliferation was also higher in the 50, 100, 150, and 200 mg/L folic acid groups compared with the control group after culture for 96 hours. Proliferation was markedly higher in the 100 mg/L folic acid group compared with the 50 mg/L folic acid group and the 40 ng/L nerve growth factor group. In Transwell assays, the number of migrated Schwann cells dramatically increased after culture with 100 and 150 mg/L folic acid compared with the control group. In nerve growth factor enzyme-linked immunosorbent assays, treatment of Schwann cell cultures with 50, 100, and 150 mg/L folic acid increased levels of nerve growth factor in the culture medium compared with the control group at 3 days. The nerve growth factor concentration of Schwann cell cultures treated with 100 mg/L folic acid group was remarkably higher than that in the 50 and 150 mg/L folic acid groups at 3 days. Nerve growth factor concentration in the 10, 50, and 100 mg/L folic acid groups was higher than that in the control group at 7 days. The nerve growth factor concentration in the 50 mg/L folic acid group was remarkably higher than that in the 10 and 100 mg/L folic acid groups at 7 days. In vivo, 80 μg/kg folic acid was intraperitoneally administrated for 7 consecutive days after sciatic nerve injury. Immunohistochemical staining showed that the number of Schwann cells in the folic acid group was greater than that in the control group. We suggest that folic acid may play a role in improving the repair of peripheral nerve injury by promoting the proliferation and migration of Schwann cells and the secretion of nerve growth factors.
European consensus-based recommendations for the diagnosis and treatment of rare paediatric vasculitides – the SHARE initiative

OBJECTIVES The European initiative Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) aimed to optimize care for children with rheumatic diseases. Systemic vasculitides are very rare in children. Consequently, despite recent advances, paediatric-specific information is sparse. The lack of evidence-based recommendations is an important, unmet need. This study aimed to provide recommendations for diagnosing and treating children with rare forms of childhood systemic vasculitis. METHODS Recommendations were developed by a consensus process in accordance with the European League Against Rheumatism standard operating procedures. A systematic literature review informed the recommendations, which were devised and evaluated by a panel of experts via an online survey, and two consensus meetings using nominal group technique. Recommendations were accepted when ⩾ 80% of experts agreed. RESULTS Ninety-three relevant articles were found, and 78 recommendations were accepted in the two consensus meetings. General, cross-cutting recommendations and disease-specific statements regarding the diagnosis and treatment of childhood-onset PAN, granulomatosis with polyangiitis, microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis, and Takayasu arteritis are provided. CONCLUSION These Single Hub and Access point for paediatric Rheumatology in Europe recommendations were formulated through an evidence-based consensus process to support uniform, high-quality standard of care for children with rare forms of paediatric systemic vasculitis.
Biogenic pentagonal silver nanoparticles for safer and more effective antibacterial therapeutics

Background Biological synthesis of nanomaterials possesses unprecedented potential in the production of nanomaterials due to their ability to produce nanomaterials with improved biocompatibility in addition to eco-friendly synthetic procedures. Methods This article reports the isolation of an air-borne fungus from the campus of Integral University, Lucknow, with an exceptional ability to withstand very high concentrations of silver salt. The fungus was found to produce pentagonal silver nanoparticles (AgPgNps) when silver ions were reduced from silver nitrate. Molecular analysis and biochemical characterization techniques based on 18-seconds rRNA identified the fungus to belong to the Aspergillus sp. with the NCBI accession no KF913249. Material characterization techniques including ultraviolet (UV)–visible spectroscopy, transmission electron microscopy, and zeta potential analysis were used to satisfactorily characterize the as-synthesized AgPgNps. Results The AgPgNps synthesized by the fungus Aspergillus sp. exhibit an absorption that is maximum centered at about 416 nm, with a standard particle size of 23.22±2 nm. These AgPgNps exhibited broad-spectrum antimicrobial activities against an array of bacterial pathogens with remarkable minimum inhibitory concentration (MIC50) values: Staphylococcus aureus (ATCC 25923) – 9.230 µg/mL, Bacillus sp. (ATCC 14593) – 12.781 µg/mL, Escherichia coli (ATCC 25922) – 5.063 µg/mL, and Klebsiella pneumoniae (ATCC 13883) – 5.426 µg/mL. In vitro cytotoxicity analysis of biosynthesized AgPgNps showed a dose–response activity against human cervical cancer cell line (HeLa) and adenocarcinoma cells (A549) with MIC50 values of 0.038 µg/mL and 0.044 µg/mL, respectively. Conclusion These findings are very crucial to evaluate the biosynthetic process for the synthesis of nanoparticles (NPs) with unique properties. These NPs may find potential applications in sensing, medicine, and antimicrobial and anticancer therapies.
Evaluation of methods for generative modeling of cell and nuclear shape

Abstract Motivation Cell shape provides both geometry for, and a reflection of, cell function. Numerous methods for describing and modeling cell shape have been described, but previous evaluation of these methods in terms of the accuracy of generative models has been limited. Results Here we compare traditional methods and deep autoencoders to build generative models for cell shapes in terms of the accuracy with which shapes can be reconstructed from models. We evaluated the methods on different collections of 2D and 3D cell images, and found that none of the methods gave accurate reconstructions using low dimensional encodings. As expected, much higher accuracies were observed using high dimensional encodings, with outline-based methods significantly outperforming image-based autoencoders. The latter tended to encode all cells as having smooth shapes, even for high dimensions. For complex 3D cell shapes, we developed a significant improvement of a method based on the spherical harmonic transform that performs significantly better than other methods. We obtained similar results for the joint modeling of cell and nuclear shape. Finally, we evaluated the modeling of shape dynamics by interpolation in the shape space. We found that our modified method provided lower deformation energies along linear interpolation paths than other methods. This allows practical shape evolution in high dimensional shape spaces. We conclude that our improved spherical harmonic based methods are preferable for cell and nuclear shape modeling, providing better representations, higher computational efficiency and requiring fewer training images than deep learning methods. Availability and implementation All software and data is available at http://murphylab.cbd. cmu.edu/software. Supplementary information Supplementary data are available at Bioinformatics online.