Miracle-dz/UniFAR-FTUs huggingface dataset:
Pulp stones following orthodontic treatment: a case-control study

The aim of this study was to analyze the incidence of pulp stones (PS) after orthodontic treatment. With a case-control design, 49 patients from a private orthodontic clinic in Curitiba, PR, Brazil, of both sexes, aged between 14 and 26 years, undergoing orthodontic intervention between the years 2000 and 2020, participated. Premolars and molars were analyzed from initial and final panoramic radiographs. Demographic and clinical data were collected from the patients’ medical records. After the initial descriptive analysis, followed by the t test for independent samples, the Chi-square test was applied to search for possible associations between the explanatory variables and the outcome of interest (post-treatment PS). Values with a significant difference were those with p < 0.05. Nineteen cases and 30 controls participated, namely 26 men and 23 women. There was no difference between groups for the age (p = 0.114) and treatment time (p = 0.204). Significant differences did not occur between cases and controls in association with the other variables (p > 0.05). In conclusion, there was no increase in PS incidence after orthodontic treatment in the sample studied.
Homologous recombination repair deficiency (HRD) testing in newly diagnosed advanced-stage epithelial ovarian cancer: A Belgian expert opinion

Ovarian cancer (OC) has a poor prognosis as most patients present with non-specific symptoms and the disease is mostly diagnosed at advanced stages. Approximately 90% of cases are classified as epithelial OC (EOC), a category comprising histologically and molecularly distinct tumours. Identifying reliable biomarkers and employing personalised therapies in OC subgroups is crucial for battling the disease. EOCs are often characterised by homologous recombination repair deficiency (HRD), frequently caused by inactivation of the breast cancer susceptibility (BRCA) genes. These findings have led to the development of poly- (adenosine diphosphate [ADP])- ribose polymerase inhibitors (PARPi), which are synthetically lethal to HRD tumour cells. Both patients with HRD and non-HRD tumours can benefit from PARPi therapy in the recurrent setting. Moreover, recent phase III trials in patients with newly diagnosed advanced-stage OC have demonstrated greater clinical benefit from PARPi in treating HRD than non-HRD tumours. These findings offer new opportunities for the use of PARPi as maintenance therapy after first-line chemotherapy based on the presence of HRD. In the current article, we provide recommendations for HRD testing and treatment of patients with newly diagnosed advanced-stage EOC.
Predictive Validity of the Static-99R in Romania

Empirical actuarial measures are significantly more accurate than unstructured clinical judgments in predicting recidivism risk of incarcerated populations across different cultures. In a retrospective study, we examined the predictive validity of the Static-99R, the actuarial measure most used around the world for assessing the recidivism risk of persons who committed a sexual offense (PCS), in a sample of 518 male PCS in Romania. The results showed a good predictive validity for any kind of recidivism (area under the curve [AUC] = .70) and a slightly lower predictive accuracy for violent (AUC = .69) and sexual recidivism (AUC = .67). Effect sizes and the predictive validity of the single items of the Static-99R have also been examined. In addition, the predicted rates of reconviction have been compared with the observed rates. The Romanian version of the Static-99R has been shown as a valid, useful tool to predict sexual, violent, and general recidivism for Romanian PCS.
An Innovative Approach to Delivering a Family-Based Intervention to Address Parental Alcohol Misuse: Qualitative Findings from a Pilot Project

Within child welfare systems, the issue of parental alcohol misuse (PAM) and the responsibility for supporting children affected by PAM impacts on multiple health and social care services. An innovation pilot project (IPP) was set up to reduce the fragmentation between services and to help identify children affected by PAM. The current study presents findings regarding the IPP, examining its implementation, the service delivery, and the perceived impact for family members. Qualitative data were collected from 41 participants. This included interviews with alcohol-misusing parents (n = 13), affected adult family members (n = 5), and children affected by PAM (n = 9). Two focus groups and three one-to-one interviews were conducted with project workers (n = 7) and multi-agency service managers (n = 7). Data were analysed thematically relating to three main themes: (1) innovation in team composition and multi-disciplinary team working, (2) innovative ways of working, and (3) the benefits of a whole-family approach. The findings highlighted the importance of time for the team to ‘bed in’ and come together under one structure, a focus and oversight on whole-family care, and the importance of offering early, targeted, and flexible interventions to prevent crisis points and manage the consequences of PAM. Consideration will need to be given to joint commissioning to strengthen family-focused support.
Insulin Resistance in Peripheral Tissues and the Brain: A Tale of Two Sites

The concept of insulin resistance has been around since a few decades after the discovery of insulin itself. To allude to the classic Charles Dicken’s novel published 62 years before the discovery of insulin, in some ways, this is the best of times, as the concept of insulin resistance has expanded to include the brain, with the realization that insulin has a life beyond the regulation of glucose. In other ways, it is the worst of times as insulin resistance is implicated in devastating diseases, including diabetes mellitus, obesity, and Alzheimer’s disease (AD) that affect the brain. Peripheral insulin resistance affects nearly a quarter of the United States population in adults over age 20. More recently, it has been implicated in AD, with the degree of brain insulin resistance correlating with cognitive decline. This has led to the investigation of brain or central nervous system (CNS) insulin resistance and the question of the relation between CNS and peripheral insulin resistance. While both may involve dysregulated insulin signaling, the two conditions are not identical and not always interlinked. In this review, we compare and contrast the similarities and differences between peripheral and CNS insulin resistance. We also discuss how an apolipoprotein involved in insulin signaling and related to AD, apolipoprotein E (apoE), has distinct pools in the periphery and CNS and can indirectly affect each system. As these systems are both separated but also linked via the blood–brain barrier (BBB), we discuss the role of the BBB in mediating some of the connections between insulin resistance in the brain and in the peripheral tissues.
Effect of Restoration on Plant Greenness and Water Use in Relation to Drought in the Riparian Corridor of the Colorado River Delta

Revitalization of the Colorado River delta riparian corridor and increasing riparian plant greenness and water use may be accomplished by added water and restoration efforts to offset declines measured since 2000 by Landsat. We use the two‐band Enhanced Vegetation Index (EVI2; a proxy for greenness) and evapotranspiration (ET, mm/day) using EVI2 and potential ET(ETo) from Yuma Valley. We assess if restoration with only 7.5% landcover had an impact on the unrestored reach‐level landcover by measuring these two metrics, EVI2 and ET(EVI2) by comparing restored and unrestored areas. A key finding is that over 21‐years EVI2 in the unrestored corridor decreased by 23.6% and ET(EVI2) decreased by 32% (0.87 mm/day). Since 2011, the unrestored reaches lost EVI2 (11%) and −0.73 mm/day ET(EVI2) (28%), but restored sites increased in EVI2 (36%) and 0.58 mm/day ET(EVI2) (20%). Water delivered to restored sites increased EVI2 by 33.6% and 1.29 mm/day ET(EVI2) (58%). EVI2 and ET(EVI2) as a function of the Standardized Precipitation Evapotranspiration Index for drought periods highlight that restored and unrestored sites respond differently. Unrestored reaches are in decline; restored sites show increases in EVI2 and ET(EVI2). Restored sites do not have a significant impact on unrestored adjacent area, but smaller surface flows, a greater reliance on directed agricultural return flows, and deliveries of water to active restoration sites have revitalized habitat and increased ecosystem services in the delta.
Decision-Making Based on Network Analyses of New Infrastructure Layouts

New Infrastructure (NI) has gradually become a new driving force for regional economic growth and an important part of the construction of new urban infrastructure in many countries, including China. Compared with traditional infrastructures, these NIs have mutually supportive functions and complex interrelationships that create interconnected networks of resources, information, and other interactions during the construction of the NIs. Therefore, it is important to analyze such correlation networks and explore their formation mechanisms in order to develop more scientific and reasonable strategies for NI investment and construction. In this study, the interdependence between NIs in Chongqing was analyzed as an example. Social network analysis (SNA) was used for the overall characteristics of the interdependency network of the NIs and an exponential random graph model (ERGM) was used to reveal the formation mechanism of this network. The results showed that information infrastructure is the key node for enhancing the effectiveness of Chongqing’s NI needs and its government should play a coordinating role. The network of related relationships is characterized by “reciprocity” and “small group”. The aggregation of NIs with such characteristics can produce an agglomeration effect. So, in the planning of NIs, the coordination among management departments should be strengthened and project locations should be reasonably arranged according to the functional interactive characteristics of the projects.
Spirituality in organizations and professional stress during Covid-19

ABSTRACT This article aims to analyze whether an organization's level of spirituality can mitigate professional stress. An online questionnaire was developed based on the following measures: A job stress scale and an organization's spirituality inventory, both were consolidated assessment applied in previous studies. This questionnaire was applied through a digital survey, strongly shared in social media and other channels, which obtained a total of 996 respondents from all over the country and with diverse demographic and professional characteristics. The data were standardized, coded and run on Stata IC v.15. in the multiple linear regression method. This study sought to enrich the knowledge on spirituality as a strategy for organizations, especially in crises situations, as Covid-19 pandemic. The results showed that the level of spirituality enhances the chance for organizations to take actions to deal with crises and reduces the professional stress in the context of uncertainties, as it is a benefit for mental health and well-being. This article could make important contributions presenting a quantitative analysis for a not usual subject in organization strategy: spirituality. It can bring new insights in people management studies, concluding that a company with greater spirituality is more likely to attract and retain people with the best talent.
The implementation of multicultural-based English language teaching in a language institution

This research aims to explore how teachers implement multicultural-based English language teaching in a language institution and students' views of teachers' implementation of multicultural-based English language teaching. This research is qualitative with a case study design. In collecting the data, the researcher used direct observation by observing teaching and learning processes to find teachers implementing multicultural-based English language teaching and semi-structured interviews to explore the students' views. There are two main points of the findings of this study: 1) there are four dimensions of multicultural education exist in the teachers' implementation of multicultural-based English language teaching: content integration, knowledge construction process, prejudice reduction, and equity pedagogy; 2) Students have positive views toward the teachers' implementation of multicultural-based English language teaching. Thus, the researcher concluded that teachers and students have positive views towards implementing multicultural-based English language teaching, and teachers have been implementing multicultural-based English language teaching in their classes. Furthermore, similar studies in the future are better to discuss the implementation of multicultural-based English language teaching using other approaches or other theories to analyze different parts of it
Future land use conflicts: Comparing spatial scenarios for urban-regional planning

Latin America’s intensive urbanization processes are triggering rapid peri-urban transformations and the expansion of cities. These include accelerated metropolization processes, urban sprawl, and the emergence of new conurbations. These changes parallel the expansion of highly profitable agricultural activities and plantations linked to international markets. This paper aims to analyze land use/cover changes between 1990 and 2050 in the Quillota Province, Valparaíso Region, Chile. Specific objectives considered (1) analyzing changes in land use/cover trajectories between 1990 and 2017, (2) simulating changes in land use/cover based on three scenarios of territorial planning to 2050 (trending, ecological planning, and spatial planning), and (3), identifying the areas most likely to be modified by urbanization and agricultural activity as a result of biodiversity loss in the study area. The Dyna-CLUE model implemented was complemented with GIS techniques for the analysis of land use/cover trajectories that allowed classifying and characterizing the most dynamic land uses/cover within the Quillota Province, such as urban land uses. The results of simulations to 2050 show a probable conurbation of medium-sized cities of Quillota-La Cruz-Calera, and future land use conflicts between peri urban-agricultural land use and plantation-natural conservation land use. The results suggest that it is essential to choose scenarios to ensure sustainable land use planning to control urban and peri-urban sprawl and protect areas of high natural value.
Understanding National Level Logistics Costs: Methodological Approach

Logistics cost (LC) estimated by different methods are not comparable since cost components differ across countries and are not properly standardised, non-availability of comprehensive reliable data on LC and presence of number of qualitative components. No method of measuring LC has considered probability distributions of the components/dimensions. After review of methods to estimate LC, the article proposes to transfer the j-th component score emerging from questionnaire-based approach to a proposed score ( P j ) so that 0 ≤ P j ≤ 100 and follows normal distribution. Logistics cost index (LCI) of i-th country is taken as multiplicative aggregation of ratios of P j at the current period and base period of all components. The index avoids perfect substitutability of arithmetic aggregation, and it satisfies the desired properties of an index including time-reversal test and formation of chain-indices, and enables meaningful comparisons across time and space, better ranking and classifying the countries, identification of critical dimensions/components requiring policy changes, drawing path of decline or increase of LCI over time for a country, computing mean LCI for a group of countries and LCI at Global level, and undertaking statistical analysis under parametric set up. Future investigations suggested reflecting properties of the proposed LCI along with empirical relationships of sector-wise LCI and economic development. JEL Codes: D57, E23, P44
Project-based learning for Master students - case Integrated Interior Wooden Surfaces.

Engineers and architects have to master the knowledge and the skills of their own field of science. Furthermore also interactional skills and the ability to work in an interdisciplinary group are needed to evolve into expert. It is increasingly important that students have an opportunity to practise all these skills during their studies. This paper describes the development of the project based course “Integrated Interior Wooden Surfaces” for Master’s level students of wood technology and wood architecture at Aalto University in Finland.
Automatic bias correction for testing in high‐dimensional linear models

Hypothesis testing is challenging due to the test statistic's complicated asymptotic distribution when it is based on a regularized estimator in high dimensions. We propose a robust testing framework for ℓ1$$ {\ell}_1 $$ ‐regularized M‐estimators to cope with non‐Gaussian distributed regression errors, using the robust approximate message passing algorithm. The proposed framework enjoys an automatically built‐in bias correction and is applicable with general convex nondifferentiable loss functions which also allows inference when the focus is a conditional quantile instead of the mean of the response. The estimator compares numerically well with the debiased and desparsified approaches while using the least squares loss function. The use of the Huber loss function demonstrates that the proposed construction provides stable confidence intervals under different regression error distributions.
Oil Media on Paper: Investigating the Effect of Linseed Oils on Lignocellulosic Paper Supports

Condition assessment of works of art created with oil media on paper could be a complex matter when presenting problems of damage due to the absorption of oil binders by the paper support, since they depend on several factors and occur in variable conditions. The present work refers to the results of an investigation on the effect of linseed oils on the color, opacity, morphology, tensile strength, and chemical properties of lignocellulosic papers, in comparison to that of pure cellulosic papers. Lignocellulosic papers are involved in research on new, yet significant, parameters that might influence the behavior of the oil-impregnated areas of the supports upon aging. The research was applied to mock-ups, made of two types of lignocellulosic paper impregnated with three types of linseed oil and subjected to accelaratated ageing in specific conditions of relative humidity and temperature in closed environment. The research involved colorimetry, opacity, tensile strength, pH measurements, SEM, FTIR, and VOC analysis with GC-MS. The results indicated that thermal-humid ageing caused the gradual darkening of the oil-impregnated mock-ups, alterations in opacity, and decrease of pH values, depending mainly on the formulation of linseed oil, as well as a reduction in tensile strength. FTIR analysis results indicated that the chemical changes that occur upon ageing supported the recorded optical and mechanical alterations, while VOC emissions are both associated with the paper type and the kinetics of degradation of the different types of linseed oil.
Pharmacokinetic Study of Coadministration with Cefuroxime Sodium for Injection Influencing ReDuNing Injection-Derived Seven Phytochemicals and Nine Metabolites in Rats

According to the sixth edition of China's “New Coronavirus Diagnosis and Treatment Plan (NCDTP),” ReDuNing injection (RDN) was firstly introduced to treat severe and critical COVID-19, whereas its combination with broad-spectrum antibiotics was suggested to take with extreme caution and full reasons. Therefore, we aim to describe the pharmacokinetics of seven active phytochemicals and semiquantification of nine relevant metabolites in ReDuNing injection (RDN) after combining with cefuroxime sodium (CNa) for injection in rat plasma. Male Sprague–Dawley rats were randomly assigned to six groups, and they were intravenously administered, respectively, with different prescriptions of RDN (2 mL/kg) and CNa (225 mg/kg). At different time points (0.03, 0.08, 0.17, 0.24, 0.33, 0.50, 0.67, 1, and 6 h) after administration, the drug concentrations of iridoids glycosides, organic acids, and metabolites in rat plasma were determined using ultrahigh-pressure liquid chromatography coupled with linear ion rap-orbitrap tandem mass spectrometry (UHPLC–LTQ–Orbitrap–MS), and main pharmacokinetic parameters were estimated by noncompartment model. The results showed that there were differences in pharmacokinetic parameters, AUC(0-t), T1/2, Cmax, CL of iridoids glycosides, and organic acids, after the intravenous administration of the different combinations of RDN and CNa. Moreover, different combinations of the injections also resulted in different curves of relative changes of each metabolite. The obtained results suggested that RDN and CNa existed pharmacokinetic drug–herb interactions in rats. The findings not only lay the foundation for evaluating the safety of RDN injection combined with CNa but also make contributions to clinically applying RDN injection combined with CNa, which works potentially against severe forms of COVID-19.
Growth Analysis and Instability in Fruits Area, Production, Productivity and Exports in India

The study focused on growth rate and instability in area, production productivity and export of fruits in India and Tamil Nadu. The present study used the secondary data collected from secondary sources. The area under fruits in Tamil Nadu and India both are increased (2.08 and 1.94 per cent) in the current year, over the base year. The compound growth rate also significantly increased (0.10 and 0.23 per cent). The production and productivity of fruits decreased in Tamil Nadu and increased in India while the compound growth rate was also negative in Tamil Nadu and positive in India. The area and its interaction effect with area were found to be responsible for decrease in the production of fruits in Tamil Nadu. The similar finding was also found in case of India the yield effect (91.84 %) followed by area effect and interaction effect of area (6.38 and 1.78 %) were found to be major contributor for increase in production of fruits. Among the three measures of instability, two measures varying confirmed that the change in production of fruits is high rather than area and productivity. The growth rate of fruits export was revealed that the compound growth rate was 0.290 in volume of export and 7.87 in value of export respectively. The increasing growth rate in value of export might be to the high instability in value of fruits exported and the instability in volume might be due to the high instability index (32.77) in production of total fruits in India.