Miracle-dz/UniFAR-FTUs huggingface dataset:
Service organisation for people with dementia after an injurious fall: challenges and opportunities

Abstract Introduction people with dementia are more likely to fall and less likely to recover well after a fall than cognitively intact older people. Little is known about how best to deliver services to this patient group. This paper explored current service provision to help inform the development of a new intervention. Methods qualitative approaches were used to explore the views and experiences of people with dementia, family carers and professionals providing services to people with dementia following an injurious fall. These data were analysed using a thematic, iterative analysis. Findings while a wide range of services potentially relevant to people with dementia was identified, there were no dedicated services for people with dementia with fall-related injuries in our three geographical areas. Factors influencing service uptake included a lack of knowledge of local provision amongst professionals and underdeveloped information sharing systems. Some aspects of current service organisation were incompatible with the needs of people with dementia. These include an emphasis on time-limited interventions; lack of longer-term follow-up; and service delivery in environments that could be challenging for people with dementia. Conclusions care pathways for people with dementia who fall are fragmented and unclear. This is likely to preclude people with dementia from receiving all appropriate support and contribute to poor recovery following a fall. The findings highlight the need for new approaches to service organisation and delivery which address the specific needs of people with dementia who fall.
An earthworm-inspired soft robot with perceptive artificial skin

The bodies of earthworms are composed of repeating deformable structural units, called metameres, that generate the peristaltic body motions required for limbless underground burrowing and above-ground crawling. Metameres are actuated by circular and longitudinal muscles that are activated synchronously by the animals’ nervous systems. A significant number of the neural-motor feedback loops function with sensory input gathered by the animals’ highly sensitive skins, which are embedded with light, pressure and chemical receptors. In this paper, adopting the basic mechanisms employed by earthworms, we propose a new type of pneumatically-driven soft robot that can travel inside pipes by mimicking the motions and replicating the functionalities of a single metamere. Furthermore, we introduce a sensing scheme for feedback control that mimics the mechanical sensory capabilities of an earthworm’s skin, which was developed upon stretchable liquid circuits capable of measuring strain and detecting pressure variations. The suitability of the proposed approach is demonstrated through several controlled locomotion experiments, employing two different robotic prototypes.
The Importance of Risk Management for the Introduction of Modern Warehouse Technologies

The purpose of the study is to determine whether the presence of risk management in a warehouse requires the implementation of modern warehouse technology. On the basis of the literature analysis, it was possible to determine that there is a correlation between the presence of the highest level of risk management and the use of modern warehouse technology in individual warehousing processes. For this purpose, a statistical analysis was carried out on a sample of companies operating in the Slovenian automotive industry. The results did not reveal a tangible correlation between the presence of risk management with the use of individual modern warehouse technology, the motivation for its use and errors in its use. The results of the study therefore, highlight the problems that are present in the warehousing system of the Slovenian companies in the automotive industry, which are related to substandard technological equipment in the warehouses and to the discrepancy between the level of manufacturing automation and the level of warehousing automation. The results are important for the Slovenian automotive industry in terms of the implementation of modern warehouse technology in the high-tech automotive industry.
Reactivation of heat-inactivated Ku proteins by heat shock cognate protein HSC73

Abstract Purpose: Mouse double-stranded DNA-dependent protein kinase (DNA-PK) activity is heat sensitive. Recovery of heat-inactivated DNA repair activity is a problem after combination therapy with radiation and heat. We investigated the mechanism of recovery of heat-inactivated DNA-PK activity. Methods: Hybrid cells containing a fragment of human chromosome 8 in scid cells (RD13B2) were used. DNA-PK activity was measured by an in vitro assay. Immunoprecipitation of the nuclear extract was performed with an anti-Ku80 antibody. Proteins co-precipitated with Ku80 were separated by sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis and detected by Western blotting using anti-heat shock protein (HSP)72 and anti-heat shock cognate protein (HSC)73 antibodies. HSC73 was overexpressed with the pcDNA3.1 vector. Short hairpin (sh)RNA was used to downregulate HSC73 and HSP72. Results: The activity of heat-inactivated DNA-PK recovered to about 50% of control during an additional incubation at 37 °C after heat treatment at 44 °C for 15 min in the presence of cycloheximide (which inhibits de novo protein synthesis). Maximal recovery was observed within 3 h of incubation at 37 °C after heat treatment. Constitutively expressed HSC73, which folds newly synthesized proteins, reached maximal levels 3 h after heat treatment using a co-immunoprecipitation assay with the Ku80 protein. Inhibiting HSC73, but not HSP72, expression with shRNA decreased the recovery of DNA-PK activity after heat treatment. Conclusions: These results suggest that de novo protein synthesis is unnecessary for recovery of some heat-inactivated DNA-PK. Rather, it might be reactivated by the molecular chaperone activity of HSC73, but not HSP72.
Disease mechanisms and neuroprotection by tauroursodeoxycholic acid in Rpgr knockout mice

Mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene are the predominant cause of retinitis pigmentosa. RPGR plays a critical role as a scaffold protein in the regulation of protein trafficking from the basal body to the axoneme, where the cargoes are transported to the outer segments (OSs) of photoreceptors. This trafficking process is controlled directly by intraflagellar transport complexes and regulated by the RPGR protein complex, although the precise mechanisms have yet to be defined. We used an Rpgr conditional knockout (cko) mouse model to investigate the disease mechanisms during retinal degeneration and to evaluate the protective effects of tauroursodeoxycholic acid (TUDCA). Rhodopsin, cone opsins and transducin were mislocalized in Rpgr cko photoreceptors, while localization of NPHP4 to connecting cilia was absent, suggesting that RPGR is required for ciliary protein trafficking. Microglia were activated in advance of retinal degeneration in Rpgr cko mouse retinas. TUDCA treatment suppressed microglial activation and inflammation and prevented photoreceptor degeneration in Rpgr cko mice. Our data demonstrated that TUDCA has therapeutic potential for RPGR‐associated RP patients.
An Accurate Fall Detection System for the Elderly People Using Smartphone Inertial Sensors

In developed countries, the number of elderly people living alone is continuously increasing. These people are more vulnerable to serious health issues, such as falling down. A sensor-based system, augmented to mobile phones, can provide a much-needed prediction to the falls, where injuries and fracture possibilities can be significantly decreased. The purpose of this study is to develop a fall recognition system based on smartphone inertial sensors, which is a combination of accelerometer and gyroscope. The system can distinguish between falls and other activity daily livings (ADLs). The data output from the inertial sensor have been used by two different classifiers; artificial neural network (ANN) and support vector machine (SVM), where the objective is to find an accurate falling classifier using smartphone inertial sensors. Results show that SVM based classifier offers an accuracy of 99.27%, which outperforms the state of the art results that use smartphone data.
Effects of plant growth regulators on callogenesis, somatic embryogenesis and plantlet regeneration of Melia azedarach L.

We developed an efficient regeneration system through indirect somatic embryogenesis for Melia azedarach L. Different culture media with various plant growth regulator (PGR) combinations were evaluated. It was found that callus induction, proliferation and morphology depend strongly on the PGR combination of the culture medium. In fact, the callus induction rate varied from 7 to 100%. The highest callogenesis rate was observed on half-strength Murashige and Skoog (MS/2) medium supplemented with 3 mg/L 1-naphthalene acetic acid (NAA), 1 mg/L zeatin and 5 mg/L gibberellic acid (GA3). Calli were either white and friable, light brown and hydrated or brown and compact, with different proliferation potential. Somatic embryo formation was observed either directly on the explant or on the previously induced calli, depending on the PGR combination of the induction medium. The highest somatic embryogenesis rate was 29% in the calli induced on MS/2 medium supplemented with 3 mg/L NAA, 1 mg/L 6-benzylaminopurine (BAP) and 5 mg/L GA3. Callus induced on MS/2 medium containing 3 mg/L indole-3-butyric acid (IBA), 1 mg/L BAP and 5 mg/L GA3 showed a somatic embryogenesis rate of 5% while a similar rate was observed on the explants cultured on MS/2 medium containing 3 mg/L NAA, 1 mg/L zeatin and 5 mg/L GA3. However, in this latter case, somatic embryos were formed directly on the explant. After transferring somatic embryos to the germination medium, the germination rate was 51.28%. All germinated embryos were successfully converted into complete plantlets and showed normal growth and development.
Possibility of Decrease in a Level of Data Correlation During Processing Small Samples Using Neural Networks by Generating New Statistic Tests

Statistic tests created in the 20th century may be mapped with some equivalent artificial neurons. As a result, a network of dozens of artificial neurons that combines dozens of known statistic tests may be used for the validation of the normality hypothesis. The quality of solutions made by a neural network depends on a number of used neurons (tests). This tendency gives rise to the task of creating new statistic tests (neurons) that first and foremost require low correlation of their decision with known tests. The paper presents a forecast of attainable confidential probabilities for the validation of the normality hypothesis for a small sample of 21 tests in a network consisting of 21 artificial neurons, where each one is mapped with one traditional statistic test. When new tests are used (that should be created in the 21st century), the correlation of data is expected to lower by far, which should allow an approximately 10-fold decrease in a number of error probabilities.
Cervical Cancer Protective Behavioral Patterns Among Mexican Women Living With HPV

Purpose: Human papillomavirus (HPV) causes morbidity and mortality worldwide. Evidence-based models addressing health for women who have HPV may prevent development of cervical cancer (CC). We applied Meleis’ transition model to identify barriers and facilitators influencing CC protective behavior for women with HPV. Method: Descriptive, correlational design including nonprobabilistic sampling of women with HPV (N = 201) in Mexico. Results: Variables linked to CC protective behavior (cervical cytology, stable partner, condom use, communication) included awareness of HPV/CC as well as attitude toward diagnosis and cytological control of HPV (λ = 890, F[196.00] = 6.057, p = .001). Acceptance of HPV diagnosis related to HPV carrier attitude, stigma, age, education, and length of HPV diagnosis (R2 = .155, F[5, 195] = 8.34, p < .05). Knowledge of HPV, attitude toward HPV diagnosis/cytological control, and age had direct effects on self-efficacy for CC protective behavior (R2 = .239, F[7, 193] = 9.95, p < .05). Coping with HPV diagnosis, self-efficacy for CC protective behavior, and age were also associated with CC protective behavior (R2 = 14.6, F[3.7] = 12.39, p = .001). Conclusions: Identification of factors inhibiting or facilitating transition among women who have HPV decrease progression to CC by increasing CC protective behaviors.
Iris Recognition Method for Non Ideal Images

The issue of counterfeiting is one of the most pressing threats to people’s security because of the many complex security problems. Many systems used in the field of verification and identification but the basic criterion for choosing is the degree of safety identification. Identification and verification systems use biometric characteristics of individuals. The system of iris recognition is one of the most important biometric recognition systems. The system used iris images for 100 persons belonging to the UBIRIS V1 database. Each person has 5 captures; the total number is 500 images. A hybrid iris segmentation method combined two algorithms ChanVese (CV) and grabcut to obtain high verification rate and to detect the outer boundary and localize the iris region. The system includes several steps starting with acquiring the image of the iris, enhancing the image quality, segment iris region, determining the coordinates of iris center and radius of the pupil, convert the iris coordinates of the cutting segments from Cartesian coordinates to the polar coordinates to reduce the processing time and to avoid the noise image problems due to eyelids and eyelashes, then utilize Gabor wavelets to extract the features of iris, and finally perform the matching process using Euclidian distance. The performance indicators, which include the recognition rate, false rejection rate(FRR), False Acceptance Rate(FAR), Correct identification rate(CIR), are as follows(97.5%, 39%, 0.025%, 0.0975). The proposed system has many advantages includes high processing capability of low-quality images and low storage capacity.
The Association Between Pelvic Floor Muscle Force and General Strength and Fitness in Postpartum Women

Objective The aim of the study was to determine whether measures of muscular strength and fitness are associated with pelvic floor muscle (PFM) force 1-year postpartum in a population of primiparous women who delivered vaginally. Methods This cross-sectional analysis is an ancillary study to an ongoing prospective cohort study and includes 203 primiparous women. Procedures collected 1-year postpartum included maximal PFM force, grip strength, trunk flexor muscle endurance, percent body fat, intra-abdominal pressure during trunk flexor endurance testing, intra-abdominal pressure during strain, and self-reported physical activity. Results The mean (SD) age was 29.8 (5.0) years and the mean (SD) body mass index was 24.5 (5.2) kg/m2. Nineteen percent were of Hispanic ethnicity. The median (interquartile range) PFM force was 5.05 (2.86–7.94) N. The median (interquartile range) trunk flexor endurance time was 146.0 (78.0–267.0), whereas the mean (SD) grip strength and percent fat were 32.4 (6.4) kg and 29.4% (10.0), respectively. There were no statistically significant associations between PFM force and any of the measures tested on analyses unadjusted or adjusted for self-report of doing PFM exercises. Of other factors evaluated, non-Hispanic ethnicity, increasing age, self-reported family history of pelvic organ prolapse or urinary incontinence, and normal and obese body mass index (both compared with overweight) were associated with lower PFM force. Conclusions In primiparous women 1-year postpartum, we found no associations between PFM force and measures of strength and fitness. This study’s results are consistent with existing literature that specific, targeted, and consistent pelvic floor exercises are the best way to improve PFM strength.
Vitro plantlet regeneration from Tinospora cordifolia (Willd.) Miers - a highly valuable medicinal plant and its chemo-profiling

Tinospora cordifolia[(Willd.) Miers ex Hook. F. and Thom)] belongs to family Menispermaceae and is mostly found in tropical Indian subcontinent especially India, Sri Lanka and Bangladesh. It is an important medicinal plant species and considered as a rich source of alkaloids and terpenes which is used as a rejuvenating drug. The extract of the mature stem is useful in curing skin diseases and dry barks have anti-spasmodic, anti-pyretic, anti-allergic, anti-inflammatory and anti-leprotic properties. In the present investigation a viable in vitro regeneration protocol for mass multiplication of Tinospora cordifolia was standardized. Chemo-profiling of crude extract of Tinospora cordifolia was also investigated. The shoot buds were used for direct shoot induction and regeneration by using Murashige and Skoog (MS) medium supplemented with different concentrations of cytokinins BAP and Kinetin singly or in the combination. For auxiliary shoot proliferation and superior in shoot elongation, it was found that BAP was more effective than Kinetin among the cytokinins tested. An average multiplication rate of 6.3 shoots per explants was obtained with MS medium supplemented with 8.87 µM BAP alone. Small shootlets were transferred to MS medium supplemented with 8.87 µM BAP and 5.71 µM IAA for shoot elongation. The elongated shoots were rooted in half-strength MS medium supplemented with 2.22 µM BAP and 4.92 µM IBA. Rooted plantlets were successfully transferred to soil and established with 80% survival. The TLC profile was developed using hexane: ethyl acetate (25:5v/v) as a mobile phase and individual peak scanned at short wavelength 366nmto identify and separate the berberine in leaf, stem, and root of T. cordifolia In the antibacterial studies, it was found that Tinospora cordifolia has the most antibacterial properties against Bacillus subtilis as compare to other bacterial species. The methanolic extract of Tinospora cordifolia resulted a „zone of inhibition‟ of 18 mm at a concentration 80 mg/ml. Against Styphylococcus aureus, a 80 mg/ml methanolic extract worked best giving a „zone of inhibition‟ of 15 mm. The methanolic extracts of this species gave a „zone of inhibition‟ less than 1mm Mycococcus
Association between weekend catch-up sleep and health-related quality of life of Korean adults

Abstract Sleep debt is known to have harmful effects on health. Weekend catch-up sleep (CUS) is a behavior to cope with weekday sleep debt. However, it is unclear whether weekend CUS has advantageous effects on health because sleep hygiene guidelines recommend regularizing bed time and arousal time. The aim of this study was to identify whether weekend CUS behavior has an association with better health-related quality of life (HRQoL) According to the inclusion criteria, 4871 participants were selected from the 2016 Korea National Health and Nutrition Examination Survey. Sleep questionnaires and European quality of life scale-5 dimensions (EQ-5D) questionnaire were used to collect data about the participants’ sleep patterns and HRQoL. Odds ratios (ORs) with 95% confidence intervals (95% CIs) for each dimensional problem of EQ-5D were derived by logistic regression. Mean EQ-5D index scores were compared between weekend CUS and non-CUS groups based on their weekday sleep durations and quintile of chronotype. The ORs of dimensional problems of HRQoL of non-CUS group versus weekend CUS group were 1.63 (95% CI 1.07, 2.47) for usual activities, and 1.45 (95% CI 1.11, 1.90) for anxiety/depression. Mean EQ-5D scores of the weekend CUS group were significantly higher than those of the non-CUS group for sleeping less than 6 hours (0.953 ± 0.004 vs 0.936 ± 0.007, P = .036) and sleeping 6 to 7 hours (0.965 ± 0.003 vs 0.955 ± .0.004, P = .045). These findings were similar in the fourth quintile (Q4) of chronotype (0.965 ± 0.007 vs 0.951 ± 0.008, P = .008) and fifth quintile (Q5) (0.952 ± 0.006 vs 0.941 ± 0.007, P = .022). Weekend CUS behavior was associated with better HRQoL than non-CUS among Korean adults. Especially, it was significant in participants who slept for less than 7 hours or participants whose chronotype was the fourth or fifth quintile. Attention may be needed for subjects with sleep short time and later chronotype who do not have weekend-CUS behaviors, because there is a risk that their HRQoL might be compromised.
Velocity-Based Training: From Theory to Application

Velocity-based training (VBT) is a contemporary method of resistance training that enables accurate and objective prescription of resistance training intensities and volumes. This review provides an applied framework for the theory and application of VBT. Specifically, this review gives detail on how to: use velocity to provide objective feedback, estimate strength, develop load-velocity profiles for accurate load prescription, and how to use statistics to monitor velocity. Furthermore, a discussion on the use of velocity loss thresholds, different methods of VBT prescription, and how VBT can be implemented within traditional programming models and microcycles is provided.
The Effectiveness of AR-Geometry Interactive Book in Increasing Students’ Mathematical Reasoning Skill

Mathematics is a subject that requires the students to gain reasoning abilities. Reasoning ability can be found when students learn geometry material. However, several studies concluded that geometry material is one of the difficult material for students. Difficulty of geometry is caused by the majority of mathematics teachers still use conventional media and teaching instruments in learning, especially in term of constructing the space. This is implemented on the AR-Geometry Interactive Book. This book is designed by using the principle of interactive 3D (three-dimensional) appearance by utilizing Augmented Reality (AR) based technology. This research uses a combination of qualitative and quantitative methods. The first qualitative data was taken by depth interviews to 4 informants selected with certain conditions using purposive sampling technique. The first phase of data collection aims to explore the information related to student interest in using the AR-Geometry Interactive Book. Furthermore, the second stage data was taken using a questionnaire to 21students in class VIII of SMPN 4 Ujung Batu. The second stage of data collection aims to support the results of the first phase of the research, all data in the second stage were then analyzed descriptively using quantitative analysis tools. Overall, the results of the second analysis indicate that the AR Geometry Book is appropriate to use in learning. To see students’ mathematical reasoning abilities, tests were conducted by testing 3 essay questions. The results of the study prove that the use of AR-Geometry Interactive can improve students’ mathematical reasoning abilities.