Miracle-dz/UniFAR-FTUs huggingface dataset:
Preoperative Factors Associated with Remote Postoperative Pain Resolution and Opioid Cessation in a Mixed Surgical Cohort: Post Hoc Analysis of a Perioperative Gabapentin Trial

Background Preoperative patient-specific risk factors may elucidate the mechanisms leading to the persistence of pain and opioid use after surgery. This study aimed to determine whether similar or discordant preoperative factors were associated with the duration of postoperative pain and opioid use. Methods In this post hoc analysis of a randomized, double-blind, placebo-controlled trial of perioperative gabapentin vs active placebo, 410 patients aged 18–75 years, undergoing diverse operations underwent preoperative assessments of pain, opioid use, substance use, and psychosocial variables. After surgery, a modified Brief Pain Inventory was administered over the phone daily up to 3 months, weekly up to 6 months, and monthly up to 2 years after surgery. Pain and opioid cessation were defined as the first of 5 consecutive days of 0 out of 10 pain or no opioid use, respectively. Results Overall, 36.1%, 19.8%, and 9.5% of patients continued to report pain, and 9.5%, 2.4%, and 1.7% reported continued opioid use at 3, 6, and 12 months after surgery. Preoperative pain at the future surgical site (every 1-point increase in the Numeric Pain Rating Scale; HR 0.93; 95% CI 0.87–1.00; P=0.034), trait anxiety (every 10-point increase in the Trait Anxiety Inventory; HR 0.79; 95% CI 0.68–0.92; P=0.002), and a history of delayed recovery after injury (HR 0.62; 95% CI 0.40–0.96; P=0.034) were associated with delayed pain cessation. Preoperative opioid use (HR 0.60; 95% CI 0.39–0.92; P=0.020), elevated depressive symptoms (every 5-point increase in the Beck Depression Inventory-II score; HR 0.88; 95% CI 0.80–0.98; P=0.017), and preoperative pain outside of the surgical site (HR 0.94; 95% CI 0.89–1.00; P=0.046) were associated with delayed opioid cessation, while perioperative gabapentin promoted opioid cessation (HR 1.37; 95% CI 1.06–1.77; P=0.016). Conclusion Separate risk factors for prolonged post-surgical pain and opioid use indicate that preoperative risk stratification for each outcome may identify patients needing personalized care to augment universal protocols for perioperative pain management and conservative opioid prescribing to improve long-term outcomes.
Investigation of acute-phase proteins and cytokines response in goats with contagious caprine pleuropneumonia with special reference to their diagnostic accuracy

Acute-phase proteins (APPs) have always had valued diagnostic potentialities in response to infection. This study aimed to evaluate the diagnostic accuracy of selected APPs and proinflammatory cytokines (PIC) in goats with contagious caprine pleuropneumonia (CCPP) under field conditions. Moreover, to highlight the role of tested biomarkers in CCPP pathogenesis. Fifty-eight goats (38 confirmed cases with CCPP and 20 healthy controls) were involved in this investigation. C-reactive protein (CRP), procalcitonin (PCT), haptoglobin (HP), fibrinogen (Fb), serum amyloid A (SAA), selected PIC (IL1-α, IL1-β, IL-6, interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α)) levels were investigated in serum samples from all goats under investigation. Latex agglutination test was used for diagnosis of goats with CCPP. For microbiological investigations, nasopharyngeal swabs (from all goats), lung tissues and pleural fluids (from only necropsied goats) were collected. This study revealed that all tested parameters have a high to moderate degree of diagnostic performance for CCPP. Magnitudes of increase in levels of APPs (CRP, HP and SAA) were stronger than PIC, IFN-γ, Fb and PCT. All tested parameters showed high diagnostic accuracy (AUROC >90%), except HP (AUROC = 87.3%) and IFN-γ (AUROC = 78.8%) showed moderate accuracy in differentiation of goats with and without CCPP infection. For detecting goats with and without CCPP infection, HP had the lowest sensitivity (Se = 81.6%) and Fb had the lowest specificity (Sp = 85.0%) among the APPs parameters tested. However, PCT showed the highest Se (100%) and Sp (95.0%) to detect goats with and without CCPP infection among tested parameters. Conclusively, this study endorses the significance of selected APPs and PIC as additional screening diagnostic parameters for naturally occurring CCPP in goats. However, it does not replace traditional methods for diagnosis of CCPP in goats. Furthermore, APPs and PIC have an important role in disease pathogenesis in goats.
Individualized chemotherapy guided by the expression of ERCC1, RRM1, TUBB3, TYMS and TOP2A genes versus classic chemotherapy in the treatment of breast cancer: A comparative effectiveness study

ERCC1, RRM1, TUBB3, TYMS and TOP2A genes have been shown to be associated with drug resistance in various types of tumors; however, their roles in breast cancer chemotherapy have not been fully validated. In the present study, 140 well-matched patients with breast cancer, comprising 70 patients receiving individualized chemotherapy and 70 receiving classic chemotherapy, were analyzed. In the individualized chemotherapy group, the mRNA expression levels of ERCC1, RRM1, TUBB3, TYMS and TOP2A in breast cancer tissues were measured using multiplex branched DNA liquidchip technology prior to chemotherapy; an individualized chemotherapy regimen was developed for each patient according to the results. As a control, patients in the classic chemotherapy group received a docetaxel + epirubicin + cyclophosphamide regimen. Survival analyses were performed using the Kaplan-Meier method. The prognostic factors for disease-free survival (DFS) and overall survival (OS) in the patients were identified via Cox's proportional hazards regression model. Adverse reactions were evaluated according to the National Cancer Institute Common Toxicity Criteria 4. Compared with the classic chemotherapy group, the DFS and OS of the individualized chemotherapy group were significantly longer (DFS, 77.4 vs. 67.1 months, P=0.039; OS, 81.4 vs. 75.4 months, P=0.031), and the incidence of grade 2 or 3 palpitations and chest tightness was lower (12.9 vs. 27.1%, P=0.035). The chemotherapy strategy guided by genetic detection was an independent protection factor for DFS [hazard ratio (HR)=0.389, 95% confidence interval (CI): 0.153, 0.989, P=0.047], but not an independent protection factor for OS (HR=0.340, 95% CI: 0.107, 1.078, P=0.067). The results indicate that the combined detection of ERCC1, RRM1, TUBB3, TYMS and TOP2A gene expression and use of the results to guide individualized chemotherapy can improve treatment efficacy and reduce unnecessary toxicity.
Exploring Health Professionals’ Perceptions on Health-ID, an Electronic Integrated Patient Progress Documentation System: A Qualitative Study in Indonesia

Background Continuum of care relies on seamless communication across health professionals. Paper-based integrated patient care documentation is, therefore, obligated in hospitals in Indonesia to standardize information among health providers. However, there are several pitfalls with paper-based documentation. Reported issues regarding time, workload, incomplete patient charts, and delayed verification were seen as obstacles in the implementation of integrated patient progress notes. In an effort to tackle the issues, Health-ID (Health-Integrated Documentation) software was developed to resolve and organize health documentation to break communication boundaries between health professionals. Aim This study was part of a system evaluation of the software program after its implementation in a hospital in Indonesia. The aim was to explore health professionals’ perceptions of Health-ID. Methods A qualitative study involving in-depth face-to-face interviews with five key informants and two focus group discussions was conducted. Thematic analysis was used to analyze the data. Results Thematic analyses of the interviews and focus group discussion revealed several main themes for each of the two topics that were explored in the discussions and interviews: (1) Perceptions on the use of Health-ID: innovative intervention; useful tool. (2) Perceived barriers to the implementation of the Health-ID: workload; organizational support; millennial gaps. Conclusion The study revealed the potential of the Health-ID to generate effective communication and collaboration among health professions. Reported benefits were as follows: integrating technology in patient progress documentation has been shown to ease the work of health professionals, providing fast and reliable information on patient care updates.
Temporal trend of cardiorespiratory endurance in urban Catalan high school students over a 20 year period

Background Physical fitness is considered an important indicator of health in adolescents. However, in recent years several studies in the scientific literature have shown a considerable lower trend and an alarming worsening of the current adolescents’ physical condition when comparing with previous decades, especially in urban populations. The aim of the current study was to analyse the temporal trend in cardiorespiratory endurance (CRE) in urban Catalan adolescents over a 20-year period (1999–2019). Methods A cross-sectional analysis study considering the 20-m Shuttle Run test (SRT) results obtained in the last 20 years was carried out. 1,701 adolescents between 15 and 16 years old (914 boys and 787 girls) were divided into four groups, corresponding to consecutive periods of five years (Group 1: 1999–2004; Group 2: 2005–2009; Group 3: 2010–2014 and Group 4: 2015–2019). ANOVA was used to test the period effect on CRE and post hoc Bonferroni analysis was performed to test pairwise differences between groups (p < 0.05). Results Results showed a significantly lower performance in CRE in both sexes. The percentual negative difference was 0.67%, 9.6% and 7% for boys and 5.06%, 14.97% and 9.41% for girls, when comparing the performance in 20-m Shuttle Run test for the first period, respectively. Conclusions Results suggest that the physical fitness of Catalan urban adolescents is lower in both sexes when comparing the different analysed periods of time. Therefore, CRE adolescents should be improved in order to help to protect against cardiovascular disease and other health risks in adulthood.
Strobilanthes sunhangii (Acanthaceae), a new species from Tibet, China

Abstract A new species of Acanthaceae, Strobilanthes sunhangii, is described from Mêdog County, Tibet, China. Morphologically, the new species is closely similar to S. medogensis and S. divaricata, but S. sunhangii differs in having glabrous stems, longer spikes, glabrous rachis, double curved corolla and glabrous calyx, different stamens and style.
Practical protein chemistry : a handbook

Protein chemistry is a wide field embracing the analysis, synthesis, sequencing and separation of peptides, proteins and individual amino acids. As research work in this subject area increases, an authoritative survey of proven techniques is required. Practical Protein Chemistry is just such a book, designed primarily to be a laboratory handbook for research workers involved with proteins, it will also be of use to undergraduates and their tutors. Each chapter commences with an authoritative introduction to the subject with an account of the practical problems involved. The authors then provide full practical details of methods which they have found to work well, and references to each technique so that they can be researched in the literature with ease. Space necessarily limits the methodologies described - essentially the purification of proteins and peptides, separation of mixtures, determination, sequencing, amino acid analysis, and chemical and enzymatic degradation are all covered. Physico- chemical techniques are largely omitted - but mass spectrometry, X-ray crystallography and electron microscopy which are all important tools for structural studies are included in detail. The final chapter concerns itself with the prediction of peptide and protein structure which may be made from sequencing data.
Generating Intelligible Plumitifs Descriptions: Use Case Application with Ethical Considerations

Plumitifs (dockets) were initially a tool for law clerks. Nowadays, they are used as summaries presenting all the steps of a judicial case. Information concerning parties’ identity, jurisdiction in charge of administering the case, and some information relating to the nature and the course of the preceding are available through plumitifs. They are publicly accessible but barely understandable; they are written using abbreviations and referring to provisions from the Criminal Code of Canada, which makes them hard to reason about. In this paper, we propose a simple yet efficient multi-source language generation architecture that leverages both the plumitif and the Criminal Code’s content to generate intelligible plumitifs descriptions. It goes without saying that ethical considerations rise with these sensitive documents made readable and available at scale, legitimate concerns that we address in this paper. This is, to the best of our knowledge, the first application of plumitifs descriptions generation made available for French speakers along with an ethical discussion about the topic.
Optimized Big Bore Gas Wells for Qatar North Field

An extensive big bore gas well drilling and completions program has been in progress since 2002 to develop the giant North Field, Offshore Qatar. This is the world’s largest non-associated gas field and contains approximately 900 Tcf of abnormally pressured natural gas producing from thick, Khuff carbonate reservoirs.
Current and Future Carbon Storage Capacity in a Southeastern Pennsylvania Forest

ABSTRACT Temperate forests have a strong carbon sink capacity, although the future of this ecosystem service is uncertain in the eastern United States in light of widespread changes affecting succession. This study quantified aboveground carbon accumulation and storage in a southeastern Pennsylvania forest fragment, while assessing whether carbon storage capacity will be supported in the future. Six 0.2 ha plots were censused in 2013 and 2018 for living tree and dead wood carbon storage, as well as tree species composition. Three plots were in a 100-year-old forest, while the remainder were in a 200-year-old forest. Living tree carbon storage increased significantly over time (p < 0.05), although dead wood carbon storage did not. Living tree carbon storage, basal area, and stem density were significantly higher in the younger forest (p < 0.05). The 200-year-old forest lacked small-diameter stems (<30 cm), relative to the younger forest, although both areas contained many large-diameter trees (>60 cm). Compositional data suggest decreased future canopy tree diversity, with the native Fagus grandifolia and nonnative Acer platanoides dominating forest understories. While there is high living tree carbon storage capacity, the dead wood pool will increase over time as many large trees die. Intervention to augment regeneration and maintain sink strength in the 200-year-old forest is needed. Action to limit the spread of A. platanoides and increase native regeneration throughout the forest will support forest resilience and long-term carbon storage capacity. Assessments of understory conditions are critical in supporting forests' carbon sink capacity into the future.
Using Invasional Meltdown Theory to Understand Patterns of Invasive Richness and Abundance in Forests of the Northeastern USA

ABSTRACT Invasional meltdown hypothesizes that invasive species facilitate the establishment of subsequent invaders, with cascading consequences for ecosystem structure and function, including the extirpation of native species. However, meltdown has rarely been tested empirically with large regional data sets, leading to somewhat equivocal support. Recently, the USDA Forest Service initiated sampling of nonnative plants within a subset of their Forest Inventory and Analysis (FIA) plots, presenting an ideal dataset to evaluate meltdown and its consequences across large geographies. We used FIA data from 963 plots across 11 northeastern states to test the predictions of invasional meltdown and to examine the mechanism through which invasion impacts native tree seedling richness. Remeasured plots showed a significant increase in the number and cover of invasive species over time. We provide support for invasional meltdown, finding a pattern of accelerating invasive species richness over 4–5 y in plots with higher initial invasive species richness. Also, we found that plots with higher levels of invasive abundance corresponded to decreased native tree species richness at one point in time and that the magnitude of the relationship appeared to be stronger after 4–5 y. Our results suggest that evidence of invasional meltdown is more clearly evident when examining invasive plant species richness over time; further, invader abundance (measured as cover) is a better predictor of impacts than invader richness, which supports growing evidence that invasive abundance is an important driver of ecological impact.
Species functional traits and abundance as drivers of multiplex ecological networks: first empirical quantification of inter-layer edge weights

Many vertebrate species act as both plant pollinators and seed-dispersers, thus interconnecting these processes, particularly on islands. Ecological multilayer networks are a powerful tool to explore interdependencies between processes; however, quantifying the links between species engaging in different types of interactions (i.e. inter-layer edges) remains a great challenge. Here, we empirically measured inter-layer edge weights by quantifying the role of individually marked birds as both pollinators and seed-dispersers of Galápagos plant species over an entire year. Although most species (80%) engaged in both functions, we show that only a small proportion of individuals actually linked the two processes, highlighting the need to further consider intra-specific variability in individuals' functional roles. Furthermore, we found a high variation among species in linking both processes, i.e. some species contribute more than others to the modular organization of the multilayer network. Small and abundant species are particularly important for the cohesion of pollinator seed-dispersal networks, demonstrating the interplay between species traits and neutral processes structuring natural communities.
Foraging behaviour alters with social environment in a juvenile songbird

Early independence from parents is a critical period where social information acquired vertically may become outdated, or conflict with new information. However, across natural populations, it is unclear if newly independent young persist in using information from parents, or if group-level effects of conformity override previous behaviours. Here, we test if wild juvenile hihi (Notiomystis cincta, a New Zealand passerine) retain a foraging behaviour from parents, or if they change in response to the behaviour of peers. We provided feeding stations to parents during chick-rearing to seed alternative access routes, and then tracked their offspring's behaviour. Once independent, juveniles formed mixed-treatment social groups, where they did not retain preferences from their time with parents. Instead, juvenile groups converged over time to use one access route per group, and juveniles that moved between groups switched to copy the locally favoured option. Juvenile hihi did not copy specific individuals, even if they were more familiar with the preceding bird. Our study shows that early social experiences with parents affect initial foraging decisions, but social environments encountered later on can update transmission of arbitrary behaviours. This suggests that conformity may be widespread in animal groups, with potential cultural, ecological and evolutionary consequences.
Osteohistological analyses reveal diverse strategies of theropod dinosaur body-size evolution

The independent evolution of gigantism among dinosaurs has been a topic of long-standing interest, but it remains unclear if gigantic theropods, the largest bipeds in the fossil record, all achieved massive sizes in the same manner, or through different strategies. We perform multi-element histological analyses on a phylogenetically broad dataset sampled from eight theropod families, with a focus on gigantic tyrannosaurids and carcharodontosaurids, to reconstruct the growth strategies of these lineages and test if particular bones consistently preserve the most complete growth record. We find that in skeletally mature gigantic theropods, weight-bearing bones consistently preserve extensive growth records, whereas non-weight-bearing bones are remodelled and less useful for growth reconstruction, contrary to the pattern observed in smaller theropods and some other dinosaur clades. We find a heterochronic pattern of growth fitting an acceleration model in tyrannosaurids, with allosauroid carcharodontosaurids better fitting a model of hypermorphosis. These divergent growth patterns appear phylogenetically constrained, representing extreme versions of the growth patterns present in smaller coelurosaurs and allosauroids, respectively. This provides the first evidence of a lack of strong mechanistic or physiological constraints on size evolution in the largest bipeds in the fossil record and evidence of one of the longest-living individual dinosaurs ever documented.
Salinity-Conveyed Thermotolerance in the Coral Model Aiptasia Is Accompanied by Distinct Changes of the Bacterial Microbiome

Coral bleaching, i.e., the loss of photosynthetic algal endosymbionts, caused by ocean warming is now among the main factors driving global reef decline, making the elucidation of factors that contribute to thermotolerance important. Recent studies implicate high salinity as a contributing factor in cnidarians, potentially explaining the high thermotolerance of corals from the Arabian Seas. Here we characterized bacterial community composition under heat stress at different salinities using the coral model Aiptasia. Exposure of two Aiptasia host-algal symbiont pairings (H2-SSB01 and CC7-SSA01) to ambient (25°C) and heat stress (34°C) temperatures at low (36 PSU), intermediate (39 PSU), and high (42 PSU) salinities showed that bacterial community composition at high salinity was significantly different, concomitant with reduced bleaching susceptibility in H2-SSB01, not observed in CC7-SSA01. Elucidation of bacteria that showed increased relative abundance at high salinity, irrespective of heat stress, revealed candidate taxa that could potentially contribute to the observed increased thermotolerance. We identified 4 (H2-SSB01) and 3 (CC7-SSA01) bacterial taxa belonging to the orders Alteromonadales (1 OTU), Oligoflexales (1 OTU), Rhizobiales (2 OTUs), and Rhodobacterales (2 OTUs), suggesting that only few bacterial taxa are potential contributors to an increase in thermal tolerance at high salinities. These taxa have previously been implicated in nitrogen and DMSP cycling, processes that are considered to affect thermotolerance. Our study demonstrates microbiome restructuring in symbiotic cnidarians under heat stress at different salinities. As such, it underlines how host-associated bacterial communities adapt to prevailing environmental conditions with putative consequences for the environmental stress tolerance of the emergent metaorganism.