Miracle-dz/UniFAR-FTUs huggingface dataset:
Combination strategies based on epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors for cancer patients

Background: Combination therapy based on epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is an emerging trend in cancer treatment, but the clinical value of EGFR-TKIs combination therapy remains controversial. Thus, we conducted a comprehensive analysis of randomized controlled trials (RCTs) comparing EGFR-TKIs combination therapies with monotherapies, aiming to evaluate the safety and efficacy of EGFR-TKIs based combination therapy and to find a more beneficial combination strategy. Methods: We searched for clinical studies that evaluated EGFR-TKIs combination therapy in cancer. We extracted data from these studies to evaluate the relative risk (RR) of overall response rate (ORR) and grade 3/4 treatment-related adverse events (AEs), the hazard ratios (HRs) of overall survival (OS), and progression-free survival (PFS). Results: Fourteen RCTs were identified (n = 3774). Treatments included combinations of EGFR-TKIs and chemotherapy, combinations of EGFR-TKIs and radiotherapy, and combinations of EGFR-TKIs and bevacizumab. EGFR-TKIs combination therapies showed higher ORR [RR: 1.62; 95% confidence interval (95% CI):1.16–2.26; P = . 005], PFS (HR: 0.76; 95% CI: 0.64–0.89; P = .001), and OS (HR: 0.88; 95% CI: 0.79–0.97; P = .013) values than monotherapies. However, higher grade 3/4 treatment-related AEs (RR: 1.79; 95% CI: 1.02–3.15; P = .000) were observed in combination therapy than in monotherapy. Conclusion: Our pooled analysis and subgroup analysis results showed that the addition of chemotherapy to EGFR-TKIs better benefits PFS and safety. Adding bevacizumab was associated with better ORR and OS. The efficacy and safety of a bevacizumab-EGFR-TKIs-chemotherapy combination should be investigated further.
Four notable additions to the South African echinoid fauna (Echinodermata, Echinoidea)

Abstract Although a comprehensive guide to the South African echinoid fauna was published as recently as 2017, four notable additions to the fauna have emerged since that time and are reported on here. The first South African records for Histocidarispurpurata (Thomson, 1872), Echinothrixdiadema (Linnaeus, 1758), Microcyphusrousseaui L. Agassiz, in Agassiz and Desor 1846, and Pseudoboletiamaculata Troschel, 1869 are presented. All four species have previously been recorded from the Atlantic and/or Indian Oceans and their ranges are thus extended southwards here. These additions increase the total number of echinoid species known from South Africa to 74.
The meiotic phosphatase GSP-2/PP1 promotes germline immortality and small RNA-mediated genome silencing

Germ cell immortality, or transgenerational maintenance of the germ line, could be promoted by mechanisms that could occur in either mitotic or meiotic germ cells. Here we report for the first time that the GSP-2 PP1/Glc7 phosphatase promotes germ cell immortality. Small RNA-induced genome silencing is known to promote germ cell immortality, and we identified a separation-of-function allele of C. elegans gsp-2 that is compromised for germ cell immortality and is also defective for small RNA-induced genome silencing and meiotic but not mitotic chromosome segregation. Previous work has shown that GSP-2 is recruited to meiotic chromosomes by LAB-1, which also promoted germ cell immortality. At the generation of sterility, gsp-2 and lab-1 mutant adults displayed germline degeneration, univalents, histone methylation and histone phosphorylation defects in oocytes, phenotypes that mirror those observed in sterile small RNA-mediated genome silencing mutants. Our data suggest that a meiosis-specific function of GSP-2 ties small RNA-mediated silencing of the epigenome to germ cell immortality. We also show that transgenerational epigenomic silencing at hemizygous genetic elements requires the GSP-2 phosphatase, suggesting a functional link to small RNAs. Given that LAB-1 localizes to the interface between homologous chromosomes during pachytene, we hypothesize that small localized discontinuities at this interface could promote genomic silencing in a manner that depends on small RNAs and the GSP-2 phosphatase.
The Moderating Effects of Strategic Human Resource on Organizational Performance of Selected NGOs in Saudi Arabia

Over the last decade, organizations have been aware of the vital role human resources play in achieving better performance. Nevertheless, non-governmental organizations are not fully aware of this problem and need to make more use of human resource strategies to improve their organizational efficiency. Thus, the purpose of this study was to examine the relationship between Strategic Human Resource Management (SHRM) and organizational performance in non-governmental organizations and to determine the extent of the impact on organizational performance of SHRM (acquisition, training, retention and internal labor market); Data were collected through hard copy questionnaires distributed to 531 management and non-management staff of non-profit organizations based in Riyadh, Al-Qassim and Al-Sharqiyah districts of Saudi Arabia. The study's instrument included 45 items and was designed to assess the practices of Strategic Human Resources (SHR), mediator variables and organizational performance. Hypothesized relationships between SHRM, organizational performance and mediators were then tested using Structural Equation Modeling. The results of the analysis showed that SHRM was significantly and positively related to organizational performance. Moreover, the results have shown that mediator variables, such as employee engagement, play a significant role in mediating between SHRM and organizational performance. The results showed that the acquisition and retention of all four independent variables had the greatest impact on organizational performance. In addition, the results of this study indicated that the mediated variables successfully mediated between the SHRM and the operational performance of non-governmental organizations. Finally, the results may help shape the foundation for practical guidelines for administrators of non-governmental organizations of promoting human resource management activity and for workers associated with preserving their strategic edge for long-term organizational
Modelling Software Reliability Growth Phenomenon In Distributed Development Environment

: The present scenario of software development life-cycle has switched into a distributed environment because of the development of network technology and ever increased demand of sharing the resources to optimize the cost. In the software reliability engineering literature, few attempts have been made to model the fault testing and debugging process in a distributed development environment. One of the reasons can be attributed to the complexity involved in developing large-scale distributed systems. As a result, their testing and debugging process is influenced by many internal and external factors, all of which may not be deterministic in nature. Since reliability is the only measure of software quality, a software reliability model is needed to estimate the current reliability level and the time and resources required to achieve the objective reliability level. As the area of software fault-debugging in distributed development environment is not thoroughly investigated in current literature, even though it is estimated to have been one of the most expensive endeavor in the industry. This objective dictates developing a non-homogenous Poisson Process based testing-effort dependent software-reliability modelling approach for distributed-systems developed under imperfect-debugging environment. The resultant integrated modelling approach describes the relationship among the calendar time, the testing-effort consumption, and fault-correction/debugging process under imperfect-debugging environment. To the best of our knowledge this is the first time that this kind of integration modelling approach has been carried out for distributed systems. Fault-debugging process and testing-effort expenditures are described by a non-homogenous Poisson process and testing-effort curve functions respectively. Such a type of integrated modelling approach is very much suited also for object-oriented software development. Actual software reliability data cited in literature have been employed to demonstrate the applicability of the proposed integrated modelling approach. The results are fairly encouraging when compared with other existing approaches developed under similar environment .
IOT BASED AIR AND SOUND POLLUTION MONITORING SYSTEM- A REVIEW

This article proposes and analyse a system which is used for air and sound pollution monitoring. The system is fully Internet of Things (IOT) based and highly desirable in field of pollution control. In this system we can detect the level of pollution (Air or Sound) time by time. The article explains the different units such as hardware and software used in the proposed system and also explains the modelling and working of the basic components used in the proposed system such that IOT and its working, Microcontroller(Arduino Uno R3) and its architecture, Gas sensor and its features, Sound sensors and its specifications and ESP8266 Wi-Fi Model.
Emotional Intelligence and Interpersonal Relations in Service Industries in Nigeria

The study examined emotional intelligence and interpersonal relations. Unethical behaviour of employees that arises as a result of emotion made this investigation necessary. The objectives of the study were; to determine the nature of relationship between self-awareness and empathy toward colleagues in the organization and to ascertain the nature of relationship between social skill and improved team work within the organization. To achieve the objectives, a survey research design was adopted. The population of the study comprised of 167 staff of the selected deposit money banks and Taro Yamane formula was used to derive 118 as the sample size of the study. The techniques employed in analyzing the data were descriptive statistics and Spearman Rank Correlation Coefficient. The results indicated that self-awareness has a positive and significant relationship with empathy toward colleagues in the organization and also social skill has a positive and significant relationship with improved team work with-in the organization. Based on the findings, the study concluded that emotional intelligence has relationship with interpersonal relations. It was recommended among others that managers of deposit money banks need to deploy means of enhancing social skills and abilities of the employees through (seminars and workshop) in other to improve the level of team work and employees’ involvement in the workplace.
FULLY AUTOMATIC RANDOM NOISE ATTENUATION USING EMPIRICAL WAVELET TRANSFORM

Chen, W. , Song, H. and Chuai, X.Y. , 2019. Fully automatic random noise attenuation using empirical wavelet transform. Journal of Seismic Exploration, 28: 147-162. Strong noise in seismic data seriously affects many steps in seismic data processing and imaging. While most traditional methods depend on carefully tuned input parameters by human, we are proposing an automatic noise attenuation algorithm to facilitate a fast preprocessing of massive prestack seismic data. In the proposed algorithm, the non-stationary seismic data is first adaptively decomposed into empirical components via empirical wavelet transform (EWT) according to the frequency contents in the data. Then, the first component is selected to represent the useful signals. This process can be implemented in a fully automatic way. We compare the decompositions from EWT and the empirical mode decomposition (EMD) and find that the EWT has a stronger capability in separating the useful signals and the random noise. We also test the proposed algorithm in both multi-channel synthetic and field data examples. The results demonstrate that the new adaptive method can obtain better denoising performance than the state-of-the-art methods.
Theory and experiments join forces to characterize the electrocatalytic interface

Electrocatalysis is gaining impetus as a key technology in fuel cells and for the medium-term energy storage in the context of intermittent, renewable energy sources such as wind and solar power. Furthermore, electrocatalysis promises to convert rather inert molecules such as CO2 and N2 into reduced products such as CO and ammonia under relatively mild conditions (1, 2). Harnessing the full power of electrocatalysis is, however, hampered by a lack of understanding of the governing physical and chemical processes at the metal–electrolyte interface. In PNAS, Cheng et al. (3) bring key insight to the characterization of reaction intermediates during CO2 electroreduction via first-principles molecular dynamics modeling. This reaction is timely and has, over the last few years, served as the playground for advanced atomistic modeling of electrocatalysis (4⇓⇓⇓⇓–9). The general lack of understanding is due to the inherent complexity of the electrified interface and its characterization. The characterization is difficult since most metal–liquid interfaces are amorphous. Therefore, no long-range ordering can be detected. Experimentally, the characterizations heavily rely on spectroscopy that provides average molecular orientations [infrared (IR) and Raman] or elemental composition and oxidation states (X-ray photoelectron, X-ray absorption near-edge, etc.) (10⇓–12). Atomically resolved structures can be obtained only for rare, crystalline interfaces such as pyridine on gold single-crystal surfaces via scanning tunneling microscopy imaging (13, 14). Theoretically, the simulations of electrochemical interfaces are challenging for two reasons. The first challenge originates from the structure and dynamics of the interface; that is, its size and the relevant timescales. Just like for experiments, the amorphous nature of the interface means that, when working with periodic boundary conditions to well describe the metallic nature of the electrode and the liquid nature of the electrolyte, large systems need … [↵][1]1To whom correspondence should be addressed. Email: sautet{at}ucla.edu. [1]: #xref-corresp-1-1
MEDITERRANEAN SYNOPTIC SCALE INGREDIENTS INVOLVED IN HEAV Y PRECIPITATIONS EVENTS TRIGGERING OVER SOUTHERN FRANCE: A CLUSTERING APPROACH

This study is aiming at caracterizing the large scale enviro ments favouring the Heavy Precipitation Events (HPEs) that occur over the French Mediterranean coast durin g the fall season. First, the interactive links between the synoptic dynamics on the one hand and the rainfall on the other, are statiscally sampled from the present period thanks to robus t reliable datasets. The different synoptic classes of situations are sorted by two automatic classifications, o ne from the whole variability and another from a significant rainfall set of events. Then, from one or several cl sses that are associated whith the HPEs we can draw up the major meteorological ingredients of these ev ents, in terms of baroclinic intensity, low level conditions of current and moisture, or even in terms of frequ encies or rain spatial distribution. Secondly, one final objective of this work would be to investi ga e how these events could be modified or interact in a future climate. Therefore, we would assess, in the present period, how these classes are able to fairly discriminate the HPEs in order to detect their analog ues in climate simulations. Then, it would give the opportunity to run high resolution model simulations in itialized by climate model outputs to figure out the hydrometeorological impact of such extreme events in the fu ture.
The Effects on Neutral Variability of Recurrent Selective Sweeps and Background Selection

Levels of variability and rates of adaptive evolution may be affected by hitchhiking, the effect of selection on evolution at linked sites. Hitchhiking can be caused either by “selective sweeps” or by background selection, involving the spread of new favorable alleles or the elimination of deleterious mutations, respectively. Recent analyses of population genomic data have fitted models where both these processes act simultaneously, to infer the parameters of selection. Here, we investigate the consequences of relaxing a key assumption of some of these studies, that the time occupied by a selective sweep is negligible compared with the neutral coalescent time. We derive a new expression for the expected level of neutral variability in the presence of recurrent selective sweeps and background selection. We also derive approximate integral expressions for the effects of recurrent selective sweeps. The accuracy of the theoretical predictions was tested against multilocus simulations, with selection, recombination, and mutation parameters that are realistic for Drosophila melanogaster. In the presence of crossing over, there is approximate agreement between the theoretical and simulation results. We show that the observed relationships between the rate of crossing over, and the level of synonymous site diversity and rate of adaptive evolution in Drosophila are probably mainly caused by background selection, whereas selective sweeps and population size changes are needed to produce the observed distortions of the site frequency spectrum.
Clade I TGACG-Motif Binding Basic Leucine Zipper Transcription Factors Mediate BLADE-ON-PETIOLE-Dependent Regulation of Development1[OPEN]

Clade I TGAs interact with BLADE-ON-PETIOLE co-activators, contributing to expression of homeobox gene ATH1, which is important for boundary establishment and plant development. Lateral organs formed by the shoot apical meristem (SAM) are separated from surrounding stem cells by regions of low growth called boundaries. Arabidopsis (Arabidopsis thaliana) BLADE-ON-PETIOLE1 (BOP1) and BOP2 represent a class of genes important for boundary patterning in land plants. Members of this family lack a DNA-binding domain and interact with TGACG-motif binding (TGA) basic Leu zipper (bZIP) transcription factors for recruitment to DNA. Here, we show that clade I bZIP transcription factors TGA1 and TGA4, previously associated with plant defense, are essential cofactors in BOP-dependent regulation of development. TGA1 and TGA4 are expressed at organ boundaries and function in the same genetic pathways as BOP1 and BOP2 required for SAM maintenance, flowering, and inflorescence architecture. Further, we show that clade I TGAs interact constitutively with BOP1 and BOP2, contributing to activation of ARABIDOPSIS THALIANA HOMEOBOX GENE1, which is needed for boundary establishment. These studies expand the functional repertoire of clade I TGA factors in development and defense.
miR‐574‐5p as RNA decoy for CUGBP1 stimulates human lung tumor growth by mPGES‐1 induction

MicroRNAs (miRs) are important posttranscriptional regulators of gene expression. Besides their well‐characterized inhibitory effects on mRNA stability and translation, miRs can also activate gene expression. In this study, we identified a novel noncanonical function of miR‐574‐5p. We found that miR‐574‐5p acts as an RNA decoy to CUG RNA‐binding protein 1 (CUGBP1) and antagonizes its function. MiR‐574‐5p induces microsomal prostaglandin E synthase‐1 (mPGES‐1) expression by preventing CUGBP1 binding to its 3′UTR, leading to an enhanced alternative splicing and generation of an mPGES‐1 3′UTR isoform, increased mPGES‐1 protein expression, PGE2 formation, and tumor growth in vivo. miR‐574‐5p–induced tumor growth in mice could be completely inhibited with the mPGES‐1 inhibitor OIL Moreover, miR‐574‐5p is induced by IL‐1β and is strongly overexpressed in human nonsmall cell lung cancer where high mPGES‐1 expression correlates with a low survival rate. The discovered function of miR‐574‐5p as a CUGBP1 decoy opens up new therapeutic opportunities. It might serve as a stratification marker to select lung tumor patients who respond to the pharmacological inhibition of PGE2 formation. —Saul, M. J., Baumann, I. , Bruno, A. , Emmerich, A. C. , Wellstein, J., Ottinger, S. M. , Contursi, A. , Dovizio, M. , Donnini, S. , Tacconelli, S. , Raouf, J., Idborg, H. , Stein, S. , Korotkova, M. , Savai, R. , Terzuoli, E. , Sala, G. , Seeger, W. , Jakobsson, P.‐J., Patrignani, P., Suess, B. , Steinhilber, D. miR‐574‐5p as RNA decoy for CUGBP1 stimulates human lung tumor growth by mPGES‐1 induction. FASEB J. 33, 6933–6947 (2019). www.fasebj. org
Extraction and Systematic Synthesis of Textual Information by Contextualization and Enrichment : Applications of Automated Reasoning in the Cognitive Sciences

One of the major problems in AI and Deep Learning is Commonsense Reasoning. As easy as it is for humans to perform certain tasks without having to think and waste much time, machines have diﬃculties in performing those tasks without necessarily been programmed.The Winograd schema is one of the recommended ways for testing the Commonsense reasoning ability of machines. It is diﬃcult for machines to answer this Winograd Schema. In this work, we propose the use of neural network based on Language Models in tackling this problem. Our network takes in only word inputs for the training on large vocabulary size. This model attains an accuracy of 54.58 percent when ran on the Winograd Schema Challenge.
Omega-3 and ranibizumab for age-related macular degeneration

Background: Omega-3 and ranibizumab (O3R) has been reported to treat age-related macular degeneration (ARMD) effectively. However, up to the present, no systematic review specifically addressed the efficacy of O3R for the treatment of ARMD. Therefore, in this study, we will propose to assess the efficacy and safety of O3R for the treatment of ARMD. Methods: We will search PUMBED, EMBASE, CINAHI, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, Cochrane Library, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, VIP Information, Wanfang Data, as well as the gray literature from inception up to the present. We will accept randomized controlled trials for assessing the efficacy and safety of O3R for ARMD. The primary outcomes include change in best corrected visual acuity and central retinal thickness. The secondary outcomes consist of changes in subfoveal choroidal thickness, macular atrophy, retinal average sensitivity, contrast sensitivity, glare disability, and quality of life. In addition, incidence and severity of adverse events will also be evaluated. Cochrane Collaboration tool will be used to assess the risk of bias for each included study. In addition, Grading of Recommendations Assessment, Development, and Evaluation tool will be utilized to assess the overall strength of the evidence. Two authors will independently carry out all procedures and any divergences will be solved through discussion with a third author. If it is possible, we will conduct meta-analysis and subgroup analysis concerning different interventions, risk of bias, and outcome measurements. Results: In this proposed study, we outline details of the aims and methods of efficacy and safety of O3R for the treatment of ARMD. Conclusion: The findings of this systematic review will summarize current evidence of O3R for the treatment of patients with ARMD. Dissemination and ethics: The results of the present study are expected to be published by peer-reviewed journals. This is a literature-based study. Thus, ethical approval is unnecessary for this study. Systematic review registration: PROSPERO CRD42019121177.