Miracle-dz/UniFAR-FTUs huggingface dataset:
DMSO_A_251491 2307..2316

Jun Zhou Ruilian Zhe Xiaohui Guo Yuying Chen 1 Yan Zou Li Zhou Zhijian Wang 1Department of Obstetrics, Shenzhen People’s Hospital, Shenzhen 518000, People’s Republic of China; 2Emergency Department of Shenzhen Maternal and Child Health Hospital, Shenzhen 518000, People’s Republic of China; 3Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510510, People’s Republic of China Background: Gestational diabetes mellitus (GDM) is a disorder of glucose metabolism that occurs or is found for the first time during pregnancy. GDM is very harmful and urgently needs drug treatment to improve pregnancy outcome. PPARδ is involved in a variety of biological processes related to glycolipid metabolism in the body, suggesting that it may be closely related to insulin resistance and impaired glucose tolerance. The role of PPARδ agonist GW501516 in gestational diabetes has not been studied. Methods: Firstly, the rat model of GDM was established. Then, fasting blood-glucose (FGB), fasting insulin (FINS), HOMA-islet resistance index (HOMA-IR) and insulin sensitivity index (ISI) of GDM rats treated with GW501516 were measured on day 3, day 10 and day 17. Glucose tolerance test was performed on the 20th day of gestation to measure glucose tolerance in rats. The expression of PPARδ and Angptl8 in islet tissues of rats was detected by Western blot and immunohistochemistry (IHC). Histopathological changes of islet were detected by HE stain; apoptosis rate of islet cells was detected by Tunel; and expression of apoptosis-related proteins in the cells was detected by Western blot. The biochemical kits were used to detect the expression of lipid metabolism-related factors in blood of GDM rats after the PPARδ agonist GW501516 treatment. Finally, the expression of SREBP-1c and GLUT2 in islet tissues was detected by RT-qPCR and IHC. Results: The PPARδ agonist GW501516 decreased the expression of FGB, FINS and HOMA-IR in GDM rats, and we found that GW501516 decreased ISI in GDM rats. GW501516 increased glucose tolerance in GDM rats too. In GDM rats, the expression of PPARδ in islet decreased and the expression of Angptl8 increased, which was reversed by GW501516. In addition, we also found that GW501516 can improve the damaged islet tissue of GDM rats, reduce the apoptosis rate of islet cells and inhibit the expression of lipid metabolism-related factors in the blood. Finally, we found that GW501516 inhibited the expression of SREBP-1c and promoted the expression of GLUT2 in the islet tissue. Conclusion: The PPARδ agonist GW501516 could improve the blood glucose level, damaged islet tissue and increase the insulin content in the rats with GDM, possibly by regulating the SREBP-1c/GLUT2 pathway. Our study provided a new basis for clinical treatment of GDM in pregnant women with PPARδ agonist GW501516.
Bosonic construction of superstring theory and related topics

This thesis splits into two parts. In the first part we introduce a bosonic construction of the ten-dimensional fermionic theories. This construction relies on a consistent truncation procedure which can produce fermions out of bosons. We illustrate this truncation procedure in the case of type II superstring theories, which emerge as the truncation of the 26-dimensional closed bosonic string theory compacified on the weight lattice of E(_8) x E(_8). The same truncation procedure can be applied to the unoriented bosonic string theory compactified on the above lattice and produces the type I superstring theory with the Chan-Paton gauge group reduced from SO(2(^13)) to SO(32). We also demonstrate that the BPS D-branes in Type I theory can be obtained from the bosonic D-branes wrapping on the above lattice by using the technique of Boundary Conformal Field Theory. In the second part, we construct new four-dimensional configurations of oppositely charged static black hole pairs (diholes) which are solutions of the low-energy effective action of string theories. The black holes are extrernal and carry four different charges. We also generalize the dihole solution to a theory which has an arbitrary number of abelian gauge fields and scalars where the diholes are composite objects. We uplift the dihole solutions to higher dimensions in order to describe intersecting brane-anti-brane configurations in string theory. The properties of the strings and membranes stretched between the brane and anti-brane are discussed.
Function and Expression Pattern of the α Subunit of the Heterotrimeric G Protein in Rice

cient for the heterotrimeric G-protein α subunit (G α ) gene of rice, shows dwarfi sm and sets small round seeds. To determine whether dwarfi sm in d1 is due to a reduction in cell number or to shortened cell length, the cell number of the leaf sheath, the internode, the root and the lemma was compared between Nipponbare, a wild-type rice and d1-5 , a d1 allele derived from Nipponbare. Our results indicate that the cell number was reduced in all organs analyzed in d1-5 . In addition, cell enlargement was found in roots and lemma of d1-5, although the organ length in d1-5 was shorter than that of wild-type rice. These results suggest that rice G α participates in cell proliferation in rice. Western blot analyses using anti-G α antibody and RT–PCR analyses indicate that G α is mostly expressed in the developing organs. G α promoter activity studies using the GUS reporter gene confi rmed that the expression of G α was highest in developing organs. We conclude that rice G α participates in the regulation of cell number in a developmental stage-dependent manner.
Burial and exhumation in a subduction wedge : mutual constraints from thermo-mechanical modelin and natural P-T-t data (Sch. Lustrés, W. Alps)

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Burial and exhumation in a subduction wedge : mutual constraints from thermo-mechanical modelin and natural P-T-t data (Sch. Lustrés, W. Alps) P. Yamato, Philippe Agard, Evgenii Burov, Latetia Le Pourhiet, Laurent Jolivet, Christel Tiberi
Tensile and Water Absorption Properties of Eggshell Powder Filled Recycled High-Density Polyethylene/Ethylene Vinyl Acetate Composites: Effect of 3-Aminopropyltriethoxysilane

The effect of 3-aminopropyltriethoxysilane (APTES) coupling agent on tensile and water absorption properties of eggshell powder (ESP) filled recycled high-density polyethylene/ethylene vinyl acetate (rHDPE/EVA) composites were investigated. The composites were prepared using a Brabender internal mixer at 190 °C and rotor speed of 50 rpm, where ESP loadings (0, 5, 10, 15, 20, 25 phr) and constant rHDPE/EVA (50/50) were used. The results indicate that the tensile modulus and water absorption increased, but tensile strength and elongation at break decreased, with increased ESP loading. The addition of the APTES to the composites exhibited a higher tensile strength and tensile modulus, but lower elongation at break and equilibrium water absorption percentage than composites without APTES. The presence of APTES has enhanced the interfacial adhesion between rHDPE/EVA matrices and ESP which result in higher tensile strength and modulus. Copyright © 2015 Penerbit Akademia Baru All rights reserved.
Participation and model ownership in group model building processes – an exploratory study based on expert interviews

Participatory modelling is a concept that is widely applied in policy making. Participation enhances the development of ownership of the model and thus commitment to the process outcomes, but also demands more time for the process. To organize participation effectively, it is relevant to know what the contribution of participation is to the process purposes. Where other studies focus on classification of participation, this research explored the effects of participation. This was done by combining literature research with consultation of various experts on the expected effects of different forms of participant involvement. The results show what degree of model ownership can be expected to develop under different forms of involvement. Furthermore, the broader relevance of participation and model ownership to participatory modelling processes is discussed. It is recommended that future research focuses on empirical validation of the theory developed in this research.
EXACT NULL-CONTROLLABILITY OF INTERCONNECTED ABSTRACT EVOLUTION EQUATIONS WITH UNBOUNDED INPUT OPERATORS

The exact null-controllability problem in the class of smooth controls with applications to interconnected systems was considered in [23] for the case of bounded input operators appearing in systems with distributed controls. The current paper constitutes an extension of the [23] for the case of unbounded input operators (with more emphasis on the controllability of interconnected systems). The proofs of the results of [23] for the case of bounded input operators are adopted for the case of unbounded input operators.
Cancer Therapy: Preclinical Natura-Alpha Targets Forkhead Box M1 and Inhibits Androgen-Dependent and -Independent Prostate Cancer Growth and Invasion

Purpose: The development of new effective therapeutic agents with minimal side effects for prostate cancer (PC) treatment is much needed. Indirubin, an active molecule identified in the traditional Chinese herbal medicine—Qing Dai (Indigo naturalis), has been used to treat leukemia for decades. However, the anticancer properties of Natura-alpha, an indirubin derivative, are not well studied in solid tumors,
CMAR_A_290566 1505..1515

1The Second Surgical Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, 300060, People’s Republic of China; 2Oncology Department, China National Petroleum Corporation Central Hospital, Langfang, Hebei Province, 065000, People’s Republic of China
DEVELOPMENT & ANALYSIS OF MOVING OBJECT FRAME CAPTURING THROUGH REAL TIME VIDEO.

--Consistent moving article recognizable proof in unconstrained scenes is a problematic task in light of dynamic establishment, changing nearer see appearance and confined computational resource. At the present time, optical stream based moving thing area layout work is proposed to address this issue. Homography matrix's to online build up an establishment model as optical stream. When settling on a choice out moving bleeding edges from scenes, a twofold mode judge instrument is proposed to raise the system's acclimation to testing conditions. In attempt segment, two appraisal estimations are rethought for even more suitably reflecting the introduction of procedures. We quantitatively and emotionally support the ampleness and reasonableness of our procedure with accounts in various scene conditions. The exploratory results show that our system changes with different conditions and beats the forefront methodologies, exhibiting the advantages of optical stream based procedures.
Encoding Glutamine Synthetase

The gene encoding glutamine synthetase (GS), ginA, was cloned from Azotobacter vinelandii on a 6-kb EcoRI fragment that also carries the ntrBC genes. The DNA sequence of 1,952 bp including the GS-coding region was determined. An open reading frame of 467 amino acids indicated a gene product of Mr 51,747. Transcription of ginA occurred from a C residue located 32 bases upstream of an ATG considered to be the initiator codon because (i) it had a nearby potential ribosome-binding site and (ii) an open reading frame translated from this site indicated good N-terminal homology to 10 other procaryotic GSs. Sequences similar to the consensus RNA polymerase recognition sites at -10 and -35 were present at the appropriate distance upstream of the transcription initiation site. As expected from earlier genetic studies indicating that expression of A. vinelandii ginA did not depend on the rpoN (ntrA; a54) gene product, no a54 recognition sequences were present, nor was there significant regulation of ginA expression by fixed nitrogen. Repeated attempts to construct glutamine auxotrophs by recombination ofglnA insertion mutations were unsuccessful. Although the mutated DNA could be found by hybridization experiments in drug-resistant A. vinelandii transformants, the wild-type ginA region was always present. These results suggest that ginA mutations are lethal in A. vinelandii. In [14C]glutamine uptake experiments, very little glutamine was incorporated into cells, suggesting that glutamine auxotrophs are nonviable because they cannot be supplied with sufficient glutamine to support growth.
The Hyperbolic Region for Restricted Isometry Constants in Compressed Sensing

— The restricted isometry constants (RIC) play an important role in compressed sensing since if RIC satisfy some bounds then sparse signals can be recovered exactly in the noiseless case and estimated stably in the noisy case. During the last few years, some bounds of RIC have obtained. The bounds of RIC 2 k δ among them were introduced by Candes (2008), Foucart and Lai (2009), Foucart (2010), Cai et al (2010), Mo and Li (2011). In the paper, we obtain a hyperbolic region on 2 k δ and k δ . It completely includes the regions of the bounds on 2 k δ obtained by the authors above, and if 2 k δ and k δ belong to the hyperbolic region then sparse signals can be recovered exactly in the noiseless case.
Upregulation of Interleukin 6 and Granulocyte Colony-Stimulating Factor Receptors by Transcription Factor CCAAT Enhancer Binding Protein a (C/EBP

From the * Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215; the ‡ Department of Pathology and Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030; and the § Division of Bone Marrow Transplantation and Stem Cell Biology, Department of Medicine, Washington University Medical School, St. Louis, Missouri 63110-1093
4_Papaya Biotechnology Vol 5.pmd

Introduction Papaya is a major tropical fruit grown commercially in India, Brazil, Mexico, Australia, Hawaii, Thailand, South Africa, Philippines, Indonesia and Taiwan. India is the largest producer of papaya contributing 25% of total world production. India is among top ten countries in the world growing 50,000 hectares or more under transgenic crops. In addition to India, other developing countries are China, Indonesia, Argentina, Brazil, Mexico and South Africa has commercialized transgenic crops. It is now being realized that the genetic base on which the conventional breeding is dependent is either shrinking or is not available because of crossability barriers. Hence, search for alternate strategies has become mandatory if the pace of horticultural growth has to be matched with the ever-increasing demand for fruits. Fortunately, advancements made in recent years in the area of recombinant DNA technology and genomics have provided an altogether new dimension to horticultural research. Research on marker assisted selection and transgenics in fruit crops has created interest globally. A large number of economic genes have been mapped, tagged, cloned, sequenced, or characterized for expression and are being used for genetic tailoring of plants through molecular breeding. An array of markers in the arsenal from RFLP to SNP; tools such as BAC, YAC, ESTs and microarrays; local physical maps of target genomic regions; and the employment of bioinformatics contributing to all the “-omics” disciplines are making the journey more and more enriching (Kole, 2007). Papaya entered in the genomics business little late. However, a rough draft of papaya genome is available now. Genetic engineering research in papaya took lead and transgenic plants expressing virus genome sequence resist attack by corresponding viruses is a reality.
SHORT- AND LONG-TERM SLEEP STABILITY IN INSOMNIACS Short- and Long-Term Sleep Stability in Insomniacs and Healthy Controls

physical examination and 8-h polysomnography (PSG) recording for 3 consecutive nights (controls and insomniacs), or 2 single nights separated by several years (PSAC). Intraclass correlation coefficients (ICCs) assessed the stability of the variables total sleep time (TST), sleep onset latency (SOL), and wake after sleep onset (WASO). We also examined persistence of the first-night classification of “short” versus “normal” sleep duration on subsequent nights. moderate in both patients with insomnia (ICC = 0.37–0.57) and controls (ICC = 0.39–0.59), and became substantial to almost perfect when based on the average of 3 nights (ICC = 0.64–0.81). We observed similar degrees of stability for TST and WASO in the longitudinal sample, with moderate stability based on a single night and substantial stability based on both nights. In examining the persistence of “short” and “normal” sleep duration, 71.4% (controls), 74.7% (patients with insomnia), and 72.6% (longitudinal sample) of participants retained their first-night classifications over subsequent nights. Conclusions: Sleep duration variables, particularly total sleep time based on 3 consecutive nights in both patients with insomnia and controls or two single-night recordings separated by several years, are stable and reflect a person’s habitual sleep. Furthermore, a single night in the laboratory may be useful for reliably classifying one’s sleep duration.
Reperfusion Injury - against Ischemia UNC5B Receptor and Protects Kidney Production and Inflammation through Netrin-1 Regulates Th1/Th2/Th17 Cytokine

Overwhelming evidence suggests that ischemia–reperfusion injury of the kidney is an inﬂammatory disease mediated by innate and adoptive immune systems. The neuronal guidance molecule netrin-1 was shown to modulate inﬂammatory responses. Given that ischemic kidney is particularly prone to reperfusion-elicited inﬂammation, we sought to determine the function of netrin-1 and its receptor UNC5B in ischemia–reperfusion-induced inﬂammation. Renal ischemia–reperfusion caused a rapid decrease in serum netrin-1 levels. Administration of recombinant netrin-1 before or after renal ischemia–reperfusion reduced kidney injury, apoptosis, monocyte and neutrophil inﬁltration, and cytokine (IL-6, IL-1 b , and TNF- a ) and chemokine (MCP-1, macrophage-derived cytokine, monokine-induced IFN- g , keratinocyte-derived chemokine, and chemokine with 6 cys-teines) production. Analysis for different netrin-1 receptors on leukocytes showed very high expression of UNC5B but not UNC5C, UNC5D, neogenin, or deleted in colorectal cancer. Expression of UNC5A was low. Neutralization of UNC5B receptor reduced netrin-1–mediated protection against renal ischemia–reperfusion injury, and it increased monocyte and neutrophil inﬁltration, as well as serum and renal cytokine and chemokine production, with increased kidney injury and renal tubular cell apoptosis. Finally, investigation into netrin-1’s effect on CD4 T cell stimulation showed suppression of Th1/Th2/Th17 cytokine (IL-2, IL-6, IL-10, IL-13, IL-17, IFN- g , IL-4, and TNF- a ) production in vitro. Our studies demonstrate that netrin-1 acting through UNC5B receptor reduces renal (28),
Feld Ferrozlne Assay of Serum Iron and Total Iron-Binding Capacity Adaptedto the COBASBlO Centrifugal Anaiyzer

1730 CLINICAL CHEMISTRY, Vol. 28, No. 7, 1982 history of BPH in a patient eventually presenting with a carcinoma of the prostate. These data can be compared with those obtained in a larger population screen of sPAP (3) with use of a radioimmunoassay of 6320 men 45 to 80 years old; 444 (7%) had increased values. On recall, 275 were BPH, including three found to have a stage A prostate cancer, and 59 of 67 who had prostatic biopsies for possible carcinoma were confirmed to have cancer. In summary, in the present study only 16 patients out of 315 had sPAP values that warranted further investigation; one was shown eventually to have prostatic cancer, in three there was confirmation of BPH on repeat biopsy, and in 12 there is, to date, no accountable reason for this increased sPAP. We do not consider it cost-effective to use sPAP assays in the long-term follow-up of asymptomatic patients after transurethral resection for benign prostatic hyperplasia.
Microwave-Assisted and Conventional Hydrodistillation of Essential Oils from Apium graveolens L

There are several methods to obtain essential oils from the plant materials. The conventional method for the extraction of essential oils is hydrodistillation (HD), in which the essential oils are evaporated by heating a mixture of water and plant materials, followed by the liquefaction of the vapours in a condenser. However, this method suffers from several disadvantages including losses in the volatile compounds, long extraction time and degradation of some components through thermal and/or hydrolytic effects. Because of these shortcomings, newer approaches such as microwave-assisted hydrodistillation (MAHD), which is an advanced hydrodistillation method based on the use of a microwave oven, have been developed. In this method, plant materials placed in a Clevenger apparatus, are heated inside a microwave oven to extract the essential oil. Heat is produced by microwave energy. The sample reaches its boiling point rapidly, leading to a very short distillation time. Apium graveolens L. belongs to the Umbelliferae family, is commonly known as celery. The celery plant is used around the world as a vegetable. It is cultivated for the green and blanched leaf stalks or, to a limited extent, the edible thickened roots and crowns. A. graveolens grows up to 30-40 cm tall and is composed of leaf-topped stalks arranged in a conical Microwave-Assisted and Conventional Hydrodistillation of Essential Oils from Apium graveolens L.
THE INTERNATIONAL JOURNAL OF HUMANITIES & SOCIAL STUDIES Reserve Management and Economic Growth in Nigeria

The study examined the impact of external reserves on the economic growth in Nigeria using secondary data from 1980 to 2018. The stationary test indicates the data in the study to be stationary at 1(0) and 1(1). The cointegration test indicates a long run relationship among the variables. The autoregressive distributed lagged model (ARDL) bounds test was adopted for the estimation of the data. The results of the study revealed that external reserves (ERSV), exchange rated (RER) and export (XPOT) has a positive and a significant impact on economic growth (RGDP) of the Nigerian economy, while import (MPOT) has negative effect on economic growth. The study recommends that adequate sterilization policies should be put in place to reduce the negative effect of the high cost of foreign exchange reserve accumulation and the need to channel and invest the foreign exchange reserve accumulated into the real sector of the economy. Since excessive import is inimical to the economic health of the Nigeria economy, the government should encourage domestic production through policies such as a reduction in tax, etc. in order to promote domestic production for goods that close substitutes for that of the ones being imported.