Miracle-dz/UniFAR-FTUs huggingface dataset:
Temporal Pitch Perception in Cochlear-Implant Users: Channel Independence in Apical Cochlear Regions

Two-electrode stimuli presented on adjacent mid-array contacts in cochlear-implant users elicit pitch percepts that are not consistent with a summation of the two temporal patterns. This indicates that low-rate temporal rate codes can be applied with considerable independence on adjacent mid-array electrodes. At issue in this study was whether a similar independence of temporal pitch cues can also be observed for more apical sites of stimulation, where temporal cues have been shown to be more reliable than place cues, in contrast to middle and basal sites. In cochlear-implant recipients with single-sided deafness implanted with long lateral-wall electrode arrays, pitch percepts were assessed by matching the pitch of dual-electrode stimuli with pure tones presented to the contralateral normal-hearing ear. The results were supported with an additional pitch-ranking experiment, in a different subject population with bilateral deafness. Unmodulated pulse trains with 100, 200, and 400 pulses per second were presented on three pairs of adjacent electrodes. Pulses were separated by the minimal interchannel delay (1.7 µs) in a short-delay configuration and by half the pulse period in a long-delay configuration. The hypothesis was that subjects would perceive a pitch corresponding to the doubled temporal pattern for the long-delay stimuli due to the summation of excitation patterns from adjacent apical electrodes, if those electrodes were to activate largely overlapping neural populations. However, we found that the mean matched acoustic pitch of the long-delay pulses was not significantly different from that of the short-delay pulses. These findings suggest that also in the apical region in long-array cochlear-implant recipients, temporal cues can be transmitted largely independently on adjacent electrodes.
Study of autologous platelet‐rich‐plasma versus its combination with intense pulsed light in treatment of melasma

Melasma is a common acquired hypermelanosis of variably successful therapies with frequent relapse. Platelet‐rich‐plasma (PRP) is a promising treatment in melasma, alone or combined with other treatments. We evaluated efficacy of autologous PRP in melasma treatment and the effect of combined intense pulsed light (IPL). Study included 20 Egyptian female melasma patients. PRP was injected in all melasma area and IPL was used on the right hemi‐face. Melasma Area and Scoring Index (MASI) of melasma area, modified‐MASI (mMASI) of PRP‐IPL side and of PRP side significantly decreased after treatments (p‐value < 0.05). There was no statistically significant difference between both sides regarding mMASI score or patient and physician satisfaction (p‐value > 0.05). Our study provides the first comparison between PRP versus its combination with IPL in melasma treatment. We think the improvement of melasma with regression of melasma scores after PRP treatment is an important finding.
Electrostatic deposition assisted preparation, characterization and evaluation of chrysin liposomes for breast cancer treatment

Abstract Chrysin (CHR), a flavone found in multiple vegetables, fruits and mushrooms has been explored so far as a neurotropic, anti-inflammatory and anti-cancer biomolecule. Despite the stated therapeutic potential, low solubility and bioavailability limit its therapeutic benefit. To circumvent these drawbacks, development of chrysin liposomes (CLPs) is reported in the present investigation. The CLPs were developed by electrostatic deposition assisted film hydration method using chitosan/lecithin to protect chrysin in the nano-lipoidal shell. Developed CLPs were extensively characterized by DSC, XPRD, FE-SEM, TEM, particle size, polydispersity index, zeta potential, percent drug loading and encapsulation efficiency. These CLPs were further characterized by in vitro dissolution, in vivo bioavailability, in vitro anticancer and stability study. Suitable particle size, PDI and ZP implying stabilization of developed CLPs. The % DL and % EE was found to be 3.56 ± 0.13 and 90.5 ± 1.49 respectively. DSC and PXRD study revealed amorphous transition of CHR, which may help to increase its solubility and dissolution profile. In vivo pharmacokinetic study demonstrated more than 5-fold increase in relative bioavailability of CLPs. The in silico molecular docking study results demonstrated the electrostatic interaction between two polymers. The present study suggests that chitosan could protect and encapsulate chrysin which eventually enhances its cytotoxicity as well as bioavailability.
High Engagement of Patients Monitored by a Digital Health Ecosystem Indicates Significant Improvements of Key r-hGH Treatment Metrics

The early adoption of digital health solutions in the treatment of growth disorders has enabled the collection and analysis of more than 10 years of real-world data using the easypod™ connect platform. Using this rich dataset, we were able to study the impact of engagement on three key treatment-related outcomes: adherence, persistence of use, and growth. In total, data for 17,906 patients were available. The three features, regularity of injection (≤2h vs >2h), change of comfort setting (yes/no), and opting-in to receive injection reminders (yes/no), were used as a proxy for engagement. Patients were assigned to the low-engagement group (n=1,752) when all of their features had the low-engagement flag (>2h, no, no) and to the high-engagement group (n=1,081) when all of their features had the high-engagement flag (≤2h, yes, yes). The low-engagement group was down-sampled to 1,081 patients (subsample of n=37 for growth) using the iterative proportional fitting algorithm. Statistical tests were used to study the impact of engagement to the outcomes. The results show that all three outcomes were significantly improved by a factor varying from 1.8 up to 2.2 when the engagement level was high. These results should encourage the promotion of engagement and associated behaviors by both patients and healthcare professionals.
A Systematic Review of the Safety and Tolerability of Theta Burst Stimulation in Children and Adolescents

Objectives: Theta burst stimulation (TBS) is often used in clinical practice and research protocols for adults with neuropsychiatric disorders. There are substantial knowledge gaps related to the application of TBS in children and adolescents. This systematic review examined the safety and tolerability of TBS in children and adolescents. Materials and Methods: A systematic review of human TBS studies in children and adolescents was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The following inclusion criteria were applied: 1) articles in English language only; 2) studies that included child and adolescent participants (up to 21 years of age); 3) studies that administered intermittent TBS or continuous TBS or both to participants; 4) studies that had an outcome measure; and 5) availability of full text material. The primary outcome measures were tolerability and safety. When feasible, the clinical effects were reviewed. Results: Twenty relevant articles met the criteria for inclusion. The reported adverse events were mild and similar to what is noted in adult studies. The most common symptom was headache. One case report described a seizure induced by TBS. Collectively, the studies were heterogeneous but the methodologic quality of randomized trials was high. Conclusions: TBS interventions in children may have similar safety, tolerability, and feasibility as compared to adults. However, long-term, follow-up studies of TBS are lacking. Future dose-ranging studies with systematic assessment of adverse events will be important in the translation of findings with TBS from adults to youth.
Insights into invasive species from whole‐genome resequencing

Studies of invasive species can simultaneously inform management strategies and quantify rapid evolution in the wild. The role of genomics in invasion science is increasingly recognised, and the growing availability of reference genomes for invasive species is paving the way for whole‐genome resequencing studies in a wide range of systems. Here, we survey the literature to assess the application of whole‐genome resequencing data in invasion biology. For some applications, such as the reconstruction of invasion routes in time and space, sequencing the whole genome of many individuals can increase the accuracy of existing methods. In other cases, population genomic approaches such as haplotype analysis can permit entirely new questions to be addressed and new technologies applied. To date whole‐genome resequencing has only been used in a handful of invasive systems, but these studies have confirmed the importance of processes such as balancing selection and hybridization in allowing invasive species to reuse existing adaptations and rapidly overcome the challenges of a foreign ecosystem. The use of genomic data does not constitute a paradigm shift per se, but by leveraging new theory, tools, and technologies, population genomics can provide unprecedented insight into basic and applied aspects of invasion science.
Outcome expectancies moderate the association between worry about climate change and personal energy-saving behaviors

This paper explores whether efficacy beliefs can alter the relationship between worry about climate change and personal energy-saving behaviors, controlling for climate change beliefs and socio-demographics. For this purpose, we used data from 23 countries that participated in the European Social Survey Round 8 (N = 44 387). Worry about climate change, personal efficacy, personal outcome expectancy, and collective outcome expectancy were each associated with personal energy-saving behaviors concerning either energy curtailment or energy efficiency. The results further show that outcome expectancies moderate the association between worry about climate change and both types of energy behaviors. Worry was more strongly related to energy curtailment behaviors among those with high levels of personal and collective outcome expectancy. A similar pattern was found for energy efficiency behaviors, which were more strongly predicted by worry about climate change when combined with high levels of collective outcome expectancy. These findings are relevant for climate change communication, especially informational campaigns aiming to lower overall household energy use.
Genome‐wide analysis of SARS‐CoV‐2 strains circulating in Vietnam: Understanding the nature of the epidemic and role of the D614G mutation

Genome‐wide analysis of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) strains is essential to better understand infectivity and virulence and to track coronavirus disease 2019 (COVID‐19) cases and outbreaks. We performed whole‐genome sequencing of 27 SARS‐CoV‐2 strains isolated between January 2020 and April 2020. A total of 54 mutations in different genomic regions was found. The D614G mutation, first detected in March 2020, was identified in 18 strains and was more likely associated with a lower cycle threshold (<25) in real‐time reverse‐transcription polymerase chain reaction diagnostic tests than the original D614 (prevalence ratio = 2.75; 95% confidence interval, 1.19–6.38). The integration of sequencing and epidemiological data suggests that SARS‐CoV‐2 transmission in both quarantine areas and in the community in Vietnam occur at the beginning of the epidemic although the country implemented strict quarantine quite early, with strict contact tracing, and testing. These findings provide insights into the nature of the epidemic, as well as shape strategies for COVID‐19 prevention and control in Vietnam.
Emotion Recognition in EEG Signals Using Decision Fusion Based Electrode Selection

Emotions are essential for the intellectual ability of human beings defined by perception, concentration, and actions. Electroencephalogram (EEG) responses have been studied in different lobes of the brain for emotion recognition. An attempt has been made in this work to identify emotional states using time-domain features, and probabilistic random forest based decision fusion. The EEG signals are collected for this from an online public database. The prefrontal and frontal electrodes, namely Fp1, Fp2, F3, F4, and Fz are considered. Eleven features are extracted from each electrode, and subjected to a probabilistic random forest. The probabilities are employed to Dempster-Shafer's (D-S) based evidence theory for electrode selection using decision fusion. Results demonstrate that the method suggested is capable of classifying emotional states. The decision fusion based electrode selection appears to be most accurate (arousal F-measure = 77.9%) in classifying the emotional states. The combination of Fp2, F3, and F4 electrodes yields higher accuracy for characterizing arousal (65.1%) and valence (57.9%) dimension. Thus, the proposed method can be used to select the critical electrodes for the classification of emotions.
Tactile Echoes: Multisensory Augmented Reality for the Hand

Touch interactions are central to many human activities, but there are few technologies for computationally augmenting free-hand interactions with real environments. Here, we describe Tactile Echoes, a finger-wearable system for augmenting touch interactions with physical objects. This system captures and processes touch-elicited vibrations in real-time in order to enliven tactile experiences. In this article, we process these signals via a parametric signal processing network in order to generate responsive tactile and auditory feedback. Just as acoustic echoes are produced through the delayed replication and modification of sounds, so are Tactile Echoes produced through transformations of vibrotactile inputs in the skin. The echoes also reflect the contact interactions and touched objects involved. A transient tap produces discrete echoes, while a continuous slide yields sustained feedback. We also demonstrate computational and spatial tracking methods that allow these effects to be selectively assigned to different objects or actions. A large variety of distinct multisensory effects can be designed via ten processing parameters. We investigated how Tactile Echoes are perceived in several perceptual experiments using multidimensional scaling methods. This allowed us to deduce low-dimensional, semantically grounded perceptual descriptions. We present several virtual and augmented reality applications of Tactile Echoes. In a user study, we found that these effects made interactions more responsive and engaging. Our findings show how to endow a large variety of touch interactions with expressive multisensory effects.
Dynamic real-time imaging of living cell traction force by piezo-phototronic light nano-antenna array

High-resolution dynamic force mapping of cardiomyocytes is revealed by nanopillars with piezo-phototronic effect. Dynamic mapping of the cell-generated force of cardiomyocytes will help provide an intrinsic understanding of the heart. However, a real-time, dynamic, and high-resolution mapping of the force distribution across a single living cell remains a challenge. Here, we established a force mapping method based on a “light nano-antenna” array with the use of piezo-phototronic effect. A spatial resolution of 800 nm and a temporal resolution of 333 ms have been demonstrated for force mapping. The dynamic mapping of cell force of live cardiomyocytes was directly derived by locating the antennas’ positions and quantifying the light intensities of the piezo-phototronic light nano-antenna array. This study presents a rapid and ultrahigh-resolution methodology for the fundamental study of cardiomyocyte behavior at the cell or subcellular level. It can provide valuable information about disease detection, drug screening, and tissue engineering for heart-related studies.
Systematic review and meta-analysis of mortality risk prediction models in adult cardiac surgery

Abstract OBJECTIVES The most used mortality risk prediction models in cardiac surgery are the European System for Cardiac Operative Risk Evaluation (ES) and Society of Thoracic Surgeons (STS) score. There is no agreement on which score should be considered more accurate nor which score should be utilized in each population subgroup. We sought to provide a thorough quantitative assessment of these 2 models. METHODS We performed a systematic literature review and captured information on discrimination, as quantified by the area under the receiver operator curve (AUC), and calibration, as quantified by the ratio of observed-to-expected mortality (O:E). We performed random effects meta-analysis of the performance of the individual models as well as pairwise comparisons and subgroup analysis by procedure type, time and continent. RESULTS The ES2 {AUC 0.783 [95% confidence interval (CI) 0.765–0.800]; O:E 1.102 (95% CI 0.943–1.289)} and STS [AUC 0.757 (95% CI 0.727–0.785); O:E 1.111 (95% CI 0.853–1.447)] showed good overall discrimination and calibration. There was no significant difference in the discrimination of the 2 models (difference in AUC −0.016; 95% CI −0.034 to −0.002; P = 0.09). However, the calibration of ES2 showed significant geographical variations (P < 0.001) and a trend towards miscalibration with time (P=0.057). This was not seen with STS. CONCLUSIONS ES2 and STS are reliable predictors of short-term mortality following adult cardiac surgery in the populations from which they were derived. STS may have broader applications when comparing outcomes across continents as compared to ES2. REGISTRATION Prospero (https://www.crd.york.ac.uk/PROSPERO/) CRD42020220983.
IT Evaluation of Foundation Healthcare Group Vanguard Project

The aim of the Foundation Healthcare Group (FHG) Vanguard model was to develop a sustainable local hospital model between two National Health Service (NHS) Trusts (a London Teaching Hospital Trust and a District General Hospital Trust) that makes best use of scarce resources and can be replicated across the NHS, UK. The aim of this study was to evaluate the provision, use and implementation of the IT infrastructure; based on qualitative interviews and focused mainly on the perspectives of the IT staff and the clinicians' perspectives. In total 24 interview transcripts, along with 'Acute Care Collaboration' questionnaire responses, were analysed using a thematic framework for IT infrastructure, sharing themes across the vascular, paediatric and cardiovascular strands of the FHG programme. Findings indicated that Skype for Business had been an innovative and helpful development widely available to be used between the two Trusts. Clinicians initially reported lack of IT support and infrastructure expected at the outset for a national Vanguard project, but later appreciated that remote access to most clinical applications between the two Trusts became operational. The Local Care Record (LCR), an IT project was perceived to have been delivered successfully in South London. Shared technology reduced patient travelling time by providing locally based shared care. Spreading and scaling-up innovations from the Vanguard sites was the aspiration and challenge for system leaders.
Optimizing the effective spot size and the dosimetric leaf gap of the AcurosXB algorithm for VMAT treatment planning

Abstract Purpose The aim of this study is to provide and test a new methodology to adjust the AcurosXB beam model for VMAT treatment plans. Method The effective target spot size of the AcurosXB v15 algorithm was adjusted in order to minimize the difference between calculated and measured penumbras. The dosimetric leaf gap (DLG) was adjusted using the asynchronous oscillating sweeping gap tests defined in the literature and the MLC transmission was measured. The impact of the four parameters on the small field output factors was assessed using a design of experiment methodology. Patient quality controls were performed for the three beam models investigated including two energies and two MLC models. Results Effective target spot sizes differed from the manufacturer recommendations and strongly depended on the MLC model considered. DLG values ranged from 0.7 to 2.3 mm and were found to be larger than the ones based on the sweeping gap tests. All parameters were found to significantly influence the calculated output factors, especially for the 0.5 cm × 0.5 cm field size. Interactions were also identified for fields smaller than 2 cm × 2 cm, suggesting that adjusting the parameters on the small field output factors should be done with caution. All patient quality controls passed the universal action limit of 90%. Conclusion The methodology provided is simple to implement in clinical practice. It was validated for three beam models covering a large variety of treatment types and localizations.
A Knowledge Graph of Mechanistic Associations Between COVID-19, Diabetes Mellitus and Kidney Diseases

This paper proposes an automated knowledge synthesis and discovery framework to analyze published literature to identify and represent underlying mechanistic associations that aggravate chronic conditions due to COVID-19. We present a literature-based discovery approach that integrates text mining, knowledge graphs and ontologies to discover semantic associations between COVID-19 and chronic disease concepts that were represented as a complex disease knowledge network that can be queried to extract plausible mechanisms by which COVID-19 may be exacerbated by underlying chronic conditions.
Effects of combined training performed two or four times per week on 24-h blood pressure, glycosylated hemoglobin and other health-related outcomes in aging individuals with hypertension: Rationale and study protocol of a randomized clinical trial

Background Acute blood pressure lowering after exercise seems to predict the extent of blood pressure reduction after chronic exercise training interventions. Based on that, the same weekly amount of exercise performed more frequently could be more beneficial for controlling blood pressure. Purpose To compare the effects of a combined training program (resistance plus aerobic exercise) performed four or two times per week on 24-h ambulatory blood pressure and other health-related outcomes in middle-aged and older individuals with hypertension. Methods This study will be a randomized, parallel group, two-arm, superiority trial. Ninety-eight participants aged 50–80 years with a previous physician diagnosis of hypertension will be randomized to perform two or four sessions per week of combined training using the same total weekly overload. Primary outcomes will be 24-h ambulatory blood pressure and glycosylated hemoglobin; secondary outcomes will be endothelial function, physical fitness and quality of life. The outcomes will be assessed at baseline and at the end of 12 weeks period. Results Our conceptual hypothesis is that a combined exercise program performed four or two times per week with equalized weekly volume/overload will improve all outcomes in comparison to the baseline values, and that reductions in 24-h blood pressure and glycosylated hemoglobin will be more pronounced in the group that trained four times a week than twice. The results of this trial are expected to provide evidences to support that higher weekly frequency of combined training should be emphasized in aging adults with hypertension.