Miracle-dz/UniFAR-FTUs huggingface dataset:
Flicker noise behavior of MOSFETs fabricated in 0.5 /spl mu/m fully depleted (FD) silicon-on-sapphire (SOS) CMOS in weak, moderate, and strong inversion

This paper presents a summary of the measured noise behavior of CMOS MOSFETs fabricated in the Peregrine 0.5 /spl mu/m fully depleted (FD) silicon-on-sapphire (SOS) process. SOS CMOS technology provides an alternative to standard bulk CMOS processes for high-density detector front-end electronics due to its inherent radiation tolerance. In this paper, the flicker noise behavior of SOS devices will be presented and discussed with reference to device inversion coefficient (IC). The concept of inversion coefficient will be introduced and the results of SOS device noise measurements in weak, moderate, and strong inversion will be presented and compared for devices with gate lengths of 0.5 /spl mu/m to 4 /spl mu/m. Details of the noise measurement system will be provided including specifics of the measurement approach and custom circuits used for device biasing. This work will provide a thorough presentation of measured SOS device flicker noise as a function of inversion coefficient. In addition, strategies for device biasing and sizing to obtain optimum flicker noise performance will be presented encouraging more widespread use of SOS integrated circuits in high-density detector applications.
Class 1 Integron in Shiga toxin-producing Esherichia coli Strains:Its Identification and Analysis

OBJECTIVE To study the distribution and characterizaton of class 1 integrons in Shiga toxin-producing Escherichia coli(STEC) from diversity source,and elucidate the status of gene-cassettes and resistance messages expressed. METHODS Routine method was used to isolate E.coliwith its sero-typing;identified stx1-2-producing strains by PCR;antibiotics susceptibility was tested by the disk diffusion method; class 1 integron was detected also by PCR assay;PCR products were sequenced and analyzed. RESULTS Of 46 STEC isolates,23 were O157∶H7.All STEC strains resisted to sulfamethoxazole-trimethoprim,and the resistantce rate to ampicillin and streptomycin was 30.4% and 28.3%,respectively.Five isolates resisted to multiple antibiotics.Eleven of 46 isolates carried class 1 integrons;and 9 strains existed aadA1,2 strains existed aadA2 gene cassettes,all come from isolates resisted to aminoglycosides,and transferred the resistance of aminoglycosides. CONCLUSIONS Class 1 integrons exist in the Shiga toxin-producing E.coli,and determine the resistance of aminoglycoside antibiotics.
NOVEL SELECTIVE INHIBITOR OF α-AMYLASE ISOENZYMES

Taking advantage of selective α-amylase inhibition by O-6-deoxy-α-D-glucopyranosyl-(1→4)-O-α-D-glucopyranosyl-(1→4)-D-glucose, we developed a new inhibitor method for the differential assay of two human α-amylase isoenzymes.
‘Nocturne’ Hybrid Blueberry: A Winter-hardy, Mixed-species Hexaploid with Ornamental Landscape Interest and Novel Fruit Quality

‘Nocturne’ Hybrid Blueberry: A Winter-hardy, Mixed-species Hexaploid with Ornamental Landscape Interest and Novel Fruit Quality Mark K. Ehlenfeldt and Robert B. Martin Marucci Center for Blueberry and Cranberry Research and Extension, Agricultural Research Service, United States Department of Agriculture, Chatsworth, NJ 08019; and Genetic Improvement of Fruits and Vegetables Laboratory, Agricultural Research Service, United States Department of Agriculture, Beltsville, MD 20705
Light propagation‐ and many‐particle‐induced non‐Lorentzian lineshapes in semiconductor nanooptics

The occurrence of non-Lorentzian lineshapes is analyzed for a variety of nanooptical semiconductor systems such as quantum wells and quantum dots. Their origin is traced back to light–matter interaction (light propagation) and many-particle correlations (electron–electron and electron– phonon interaction).
Morph‐physiological responses of two switchgrass (Panicum virgatum L.) cultivars to cadmium stress

Two cultivars of switchgrass, ‘Alamo’ (lowland type) and ‘Cave-in-Rock’ (upland type), were used to examine the morph-physiological responses of plants to different cadmium (Cd) levels under hydroponic condition treated with 0, 10, 20 and 40 μmol L−1 CdCl2 for 2 weeks. The main results showed that both seedlings of ‘Alamo’ and ‘Cave-in-Rock’ can survive even in 40 μmol L−1 CdCl2 treatment. However, the growth of the two cultivars was significantly (at least P < 0.05) inhibited by Cd stress. The plant biomass, water content, photosynthetic pigments content, total root length (RL), root surface area (RA), root volume (RV) and number of root tips of two tested cultivars were significantly decreased after treatment with Cd. ‘Alamo’ showed higher capability of Cd translocation from root to shoot than ‘Cave-in-Rock’, but ‘Cave-in-Rock’ had higher capability of Cd uptake and accumulation than ‘Alamo’. ‘Cave-in-Rock’ accumulated higher Cd in root than ‘Alamo’, the root average diameter, RL, RA and RV at the root segment in 0.3–0.9 mm diameter in ‘Cave-in-Rock’ were dramatically higher than those of ‘Alamo’, which indicates that a well-developed root system may contribute to higher Cd accumulation in ‘Cave-in-Rock’. Above all, both ‘Alamo’ and ‘Cave-in-Rock’ could be cultivated in Cd polluted area. At the same time, they have bioremediation function, especially, this function of seedling in ‘Cave-in-Rock’ should be greater than ‘Alamo’, since the amount of Cd absorption and accumulation in ‘Cave-in-Rock’ was significant higher than ‘Alamo’.
Implementation of next generation sequencing in clinical molecular diagnostic laboratories: advantages, challenges and potential

ABSTRACT Next generation sequencing (NGS) technologies have the capacity to perform massively parallel sequencing of the genome. This capacity simultaneously facilitates sequencing large areas of the genome in multiple samples and has revolutionized clinical genomics, both for discovery and diagnostic screening of genomic aberrations. The implementation of these powerful technologies in a Clinical Laboratory Improvement Amendment certified and College of American Pathologists accredited clinical laboratory presents a unique challenge due to their complexity, volume and medico-legal implications of the data generated. Here, with a focus on routine clinical cancer diagnostics, we review recent progress in the implementation of NGS, associated recommendations and guidelines, and the advantages and challenges of implementing NGS. In the light of rapidly increasing acceptance of NGS to replace the classical first generation technologies in the clinical environment, we also discuss the potential of NGS to be the new ‘gold standard’ for genome sequencing and to further improve the implementation of precision medicine.
Fermentative Production of Lactobionic Acid by Burkholderia cepacia

Lactobionic acid (LA) is derived from lactose (Lac) and has been reported to have several useful functions. LA has been supplied only as a reagent for study because it has been produced chemically in a small scale in Japan. We aimed to develop microbial production systems of LA and examined LA fermentation conditions. A three-day batch culture produced 200 g/L of LA. A ten-day fed-batch culture with periodic additions of Lac and CaCO3 accumulated 400 g/L of LA. There was no by-product and no loss of Lac, and the yield of LA-conversion was 100%. The addition of ethanol (75 % (v/v), final concentration) to culture supernatant resulted in recovery of 98 % of LA as precipitate.
DDT and DDE Effects on Migratory Condition in White-Throated Sparrows

The onset of spring migratory condition, as measured by Zugunruhe and weight increase, was delayed at least 1 week in caged white-throated sparrows (Zonotrichia albicollis) fed diets containing 5 or 25 ppm technical DDT. Migratory fat stores, determined by extraction from birds sacrificed early in the migratory period, showed a dose-dependent depression which was statistically significant only at the high dose level. Late in the period there were indications of increased Zugunruhe in treated birds. In the high treatment group, this increased activity was significantly (P < 0.05) correlated with the log of body concentration of DDE, a metabolite of ingested DDT. A similar experiment with birds fed DDE produced no effect early in the spring migratory period. Late in the period, Zugunruhe showed significant and dose-dependent increases. Daytime activity was not significantly altered. J. WILDL. MANAGE. 39(3):520-527 Several sublethal effects of organochlorine pesticides on avian reproduction, physiology, and behavior have been documented (see Pimentel 1971 or Stickel 1968 for recent reviews). Although physiological components important in the initiation or maintenance of migratory condition are known to be altered, there is no published information on the possible effects of pesticides on migratory behavior or physiology. These pesticide-sensitive components include gonadal hormones (Peakall 1967, 1969, 1970), adrenal hormones (Meier and Martin 1971, Newcomer 1959, Srebocan et al. 1971), storage fat (Keith 1970, Tinsley and Lowry 1972), and the thyroid (Jefferies 1969, Jefferies et al. 1971, Jefferies and French 1972). According to Wilson and Farner (1960) the thyroid does not function in normal control of the migratory cycle. However, thyroid dysfunction could affect the positive energy balance needed for storage of migratory fat. Ulfstrand et al. (1971) indicated that chemically similar pol chlorinated biphenyls (PCBs) increased migratory activity of caged European robins (Erithacus rubecula) in a twonight test. This study was undertaken to determine if spring migratory condition was affected in caged white-throated sparrows fed diets treated with either technical DDT (78.9 perc nt p,p'-DDT, 21.1 percent o,p-DDT) or p,p'-DDE at 5 and 25 ppm, dry weight. The research was not designed to determine causes of a possible effect. The DDT study was conducted in spring, 1970, and the DDE study was made during the following spring. I thank E.P. Odum and C.W. Helms for their encouragement and advice and T. Richardson for assistance with statistical
In vitro evaluation of functional attributes of LABs for the development of turmeric based probiotic beverage

The plant-based fermented beverages have received considerable interest for their rich nutrition, high content of soluble and insoluble fibers and for their high fermentability by probiotic lactic acid bacteria (LAB). In the present study, three LAB strains, namely Lactobacillus fermentum, Lactobacillus lactis and Lactobacillus plantarum, were used to develop a functional beverage utilizing juice of fresh turmeric rhizome as substrate for their growth and development. The survivability of probiotics in the beverage was evaluated in terms of their kinetic growth and viability in the samples was maintained during storage of 30 days. Various studies correlating their functional attributes of the developed beverage was performed like Total Titrable acidity, pH, TPC, hydrophobicity, Total Sugar estimation, transit tolerance toward acid and alkali, cholesterol assimilation, lipid peroxidation and various antioxidant analyses. The results revealed significant enhancement in probiotic properties and fermented characteristics after fermentation of LABs with fresh turmeric juice. Among investigated LABs, Lactobacillus plantarum was the best potential probiotic strain for the production of fermented turmeric based beverage.
Taxonomic revision of Bolivian Juscelinomys (Rodentia, Cricetidae) with notes on morphology and ecology

Abstract The genus Juscelinomys includes three species of rare, Cerrado-endemic Sigmodontine mice: one from Central Brazil, now listed as extinct (IUCN), and two from Bolivia, originally known only from their holotypes and listed as data deficient. Additional specimens of Bolivian Juscelinomys have provided a basis for review of morphological and DNA characters. From these, we conclude that the segregation of Juscelinomys into two Bolivian species cannot be justified, so we revise the genus to include only two named taxa: J. candango Moojen, 1965, from central Brazil and J. huanchacae Emmons, 1999, from eastern Bolivia. We provide emended diagnoses for the genus and for the Bolivian species. We present new morphological details of the feet, dentition, and stomach of J. huanchacae, and we provide notes on its ecology. Juscelinomys huanchacae occurred sporadically in both space and time during a long-term trapping program. This may account for the rarity of the genus in collections.
Elevated Plasmodium sporozoite infection and multiple insecticide resistance in the principal malaria vectors Anopheles funestus and Anopheles gambiae in a forested locality close to the Yaoundé airport, Cameroon [version 1; peer review: 1 approved, 1 approved with reservations]

Background: Reducing the burden of malaria requires better understanding of vector populations, particularly in forested regions where the incidence remains elevated. Here, we characterized malaria vectors in a locality near the Yaoundé international airport, Cameroon, including species composition, abundance, Plasmodium infection rate, insecticide resistance profiles and underlying resistance mechanisms. Open Peer Review
High fat diet in Suncus murinus

Our previous study, demonstrated the obesity-resistant phenomenon in the House musk shrew, Suncus murinus (S. murinus). In order to go further to explore the mechanism of the phenomenon of natural obesity resistance in S. murinus, we focused on the effects of diet on fat accumulation and metabolism. In this study, four-week-old male S. murinus were assigned to 1 of 2 experimental groups (n = 6 per group) and fed either a high-fat diet (HFD) or a normal trout diet (NTD) for 24 weeks. Body weight, food ingestion, visceral fat distribution, blood biochemistry and fecal lipids were monitored and analyzed in the HFD and NTD groups. It was found no differences in the average final body weight or body fat change between the two groups. Although animals fed HFD had similar serum triglyceride concentration to animals fed NTD, they had significantly higher phospholipid and total cholesterol concentrations than the NTD group. Furthermore, fecal lipid levels in the HFD group was significantly higher than those in the NTD group, suggesting that diet composition or energy density of the diet affects blood biochemistry. Although NTD-fed S. murinus had higher food ingestion than HFD-fed S. murinus, caloric intake remained almost the same. We speculated S. murinus may suppress obesity and control fat accumulation by controlling calorie intake. These results suggest that the obesity characteristics of S. murinus are not primarily due to dietary factors but to other mechanisms of regulation.
Autonomous underwater vehicles: The latest tool for archaeological investigations

In 2001, C & C Technologies, Inc. of Lafayette, Louisiana began using the HUGIN 3000 AUV in the Gulf of Mexico for offshore oil and gas surveys. This new survey vehicle is faster, more accurate, and more maneuverable than conventional deep-tow systems and has raised the bar for deepwater geophysical and hydrographic surveys. Although archaeology was not the primary purpose for developing the vehicle, archaeologists are and will continue to benefit from its use. Archaeological investigation with a conventional deep-tow system is seldom conducted during industry surveys because of the cost and time involved in operating such a system. However, during the first year of operation with the HUGIN 3000, four shipwrecks were investigated as a result of the HUGIN's cost effectiveness. The use of the HUGIN 3000 directly led to the discovery of the long sought after German submarine, U-166, which was located near its last victim, the passenger freighter SS Robert E. Lee. This AUV also helped document two additional newly discovered shipwrecks: The cargo freighter SS Alcoa Puritan and a small wooden sailing vessel known as the Mica wreck.
Developing Self-regulated Learning Skills in University Students Studying in the Open and Distance Learning Environment by Using KWL Method

Open and Distance Learning (ODL) is considered an important strategy for increasing educational access. However, students learning in ODL environments face many challenges. Studies have indicated that students with self-regulated learning (SRL) skills are more likely to succeed in ODL environments. Studies have demonstrated that through instructional strategies, tutors can teach and help improve SRL skills. This development of SRL skills may lead to reduced drop-out rates. To examine the suitability of SRL skills development strategies, the researcher of this study utilised a KWL (What I Know, What I Want to Know, What I Learned) method in the ODL environment in Sri Lanka to help develop SRL skills in university students. This study adopted an action research approach, and twenty-four (24) Bachelor of Education students and three (03) educators at the Open University of Sri Lanka were the participants. Zimmerman & Moylan's (2009) self-regulated cycle of learning model was used for the intervention. A Motivated Strategies for Learning Questionnaire (MSLQ,1991) was administered to measure students' SRL skills. Observations, reflections, and focus group discussions were used to collect qualitative data. The study's findings indicated that the KWL method contributed to the improvement of selfregulated learning skills among student participants.
A COVID-19 patient’s experience: Engagement in disease management, interactions with care teams and implications on health policies and managerial practices

This narrative inquiry aimed to explore a COVID-19 patient’s lived experience from contracting the disease to recovery and understand the implications of this unique patient experience on health policies and managerial practices. The personal narrative approach was used to chronicle the patient’s weekly journey in disease management. Best practices emerged from her and her family members’ engagement in managing COVID-19, and interactions with her primary care provider and COVID-19 Response Team. Her COVID-19 patient experience also provided a basis for implications on public health and healthcare policies and managerial practices. Three key dimensions were perceived to have positively impacted the COVID-19 patient’s experience and health outcomes: information seeking, communication, and selfawareness. Physical, mental and emotional support from family members were also perceived to have a positive impact on the patient’s experience and outcomes. Three key dimensions were perceived to have negatively impacted the COVID-19 patient’s experience and health outcomes: federal government’s lack of coordination in crisis management, CDC’s slow actions in disease control and prevention and primary care provider’s absence in care continuity. Patients must take active ownership and engage consistently in their disease management, which could help improve their own experiences and overall health outcomes. Proactive engagement in care and in making treatment decisions may improve disease outcomes even when coordinated responses to health crises were lacking in the country and care continuity by providers was absent. Interactions with care providers also present opportunities for patients to help providers improve their practices. Patients are integral members of care teams.
A Smart-M3 lab course: approach and design style to support student projects

This paper reports on the lesson learned from setting up and running a course on smart spaces based ambient intelligence within a “postgraduate” degree in Information & Computer Science Engineering. The course consists of a lab module where students are asked to propose, develop and demonstrate simple smart environment applications. Specifically, the course is built around Smart-M3, the open source interoperability component of an open innovation platform developed within the European Project SOFIA (2009-11). This paper illustrates the above summarized course, presenting the design style and the application development flow specifically devised for the course, the students evaluation approach taken, the course achievements, the issues that still need to be handled, and it will envisage topics and further extensions.
Emergent constraints on TCR and ECS from simulated historical warming in CMIP5 and CMIP6 models

Climate sensitivity to CO2 remains the key uncertainty in projections of future climate change. Transient climate response (TCR) is the metric of temperature sensitivity that is most relevant to warming in the next few decades, and contributes the biggest uncertainty to estimates of the carbon budgets consistent with the Paris targets. Equilibrium climate sensitivity (ECS) is vital for understanding longer-term climate change and stabilization targets. In the IPCC 5th Assessment Report (AR5), the stated ‘likely’ ranges (16–84% confidence) of TCR (1.0–2.5 K) and ECS (1.5–4.5 K) were broadly consistent with 5 the ensemble of CMIP5 Earth System Models (ESMs) available at the time. However, many of the latest CMIP6 ESMs have larger climate sensitivities, with 5 of 34 models having TCR values above 2.5 K, and an ensemble mean TCR of 2.0 ± 0.4 K. Even starker, 12 of 34 models have an ECS value above 4.5 K. On the face of it, these latest ESM results suggest that the IPCC likely ranges may need revising upwards, which would cast further doubt on the feasibility of the Paris targets. Here we show that rather than increasing the uncertainty in climate sensitivity, the CMIP6 models help to constrain the 10 likely range of TCR to 1.3–2.1 K, with a central estimate of 1.68 K. We reach this conclusion through an emergent constraint approach which relates the value of TCR linearly to the global warming from 1975 onwards. This is a period when the signalto-noise ratio of the net radiative forcing increases strongly, so that uncertainties in aerosol forcing become progressively less problematic. We find a consistent emergent constraint on TCR when we apply the same method to CMIP5 models. Our constraints on TCR are in good agreement with other recent studies which analysed CMIP ensembles. The relationship between 15 ECS and the post-1975 warming trend is less direct and also non-linear. However, we are able to derive a likely range of ECS of 1.9–3.4 K from the CMIP6 models by assuming an underlying emergent relationship based on a 2-box energy balance model. Despite some methodological differences, this is consistent with a previously-published ECS constraint derived from warming trends in CMIP5 models to 2005. Our results seem to be part of a growing consensus amongst studies that have applied the emergent constraint approach to different model ensembles and to different aspects of the record of global warming. 20