Miracle-dz/UniFAR-FTUs huggingface dataset:
POSITIVE p-HARMONIC FUNCTIONS ON GRAPHS

Suppose that an inflnite graph G of bounded degree has flnite number of ends, each of which is p-regular, where 1 < p < 1. Then we can identify all the positive (bounded, respectively) p-harmonic functions on G. In this paper, we study the Liouville type property on a graph. By the Liouville property on a graph G, we mean that every bounded har- monic function on G is constant. It immediately follows that the set of all bounded harmonic functions on G having Liouville property is in one to one correspondence with the real line R. It seems natural to regard the case that the set of all bounded harmonic functions on G is in one to one correspondence with R l for some positive integer l as a general- ized version of the Liouville property. In line with this view point, we consider the case of the p-Laplacian operator (1 < p < 1) and the posi- tive (bounded, respectively) p-harmonic functions on graphs of bounded degree. In the case that a graph G has a flnite number of ends, each of which is p-regular, we identify all the positive (bounded, respectively) p-harmonic functions on G in section 4. On the other hand, Kanai(5) proved that if G and H are roughly isometric graphs of bounded degree, then H is parabolic whenever G is. In (9), Soardi proved that if G and H are roughly isometric graphs of bounded degree, and if G has no nonconstant harmonic functions with flnite energy, then neither has H. Later, the second author (8) proved that the dimension of the space of harmonic functions with flnite energy is preserved under rough isometries between graphs of bounded degree. In this paper, we also discuss its rough isometric invariance in section 3
Machine Learning a General-Purpose Interatomic Potential for Silicon

The success of first principles electronic structure calculation for predictive modeling in chemistry, solid state physics, and materials science is constrained by the limitations on simulated length and time scales due to computational cost and its scaling. Techniques based on machine learning ideas for interpolating the Born-Oppenheimer potential energy surface without explicitly describing electrons have recently shown great promise, but accurately and efficiently fitting the physically relevant space of configurations has remained a challenging goal. Here we present a Gaussian Approximation Potential for silicon that achieves this milestone, accurately reproducing density functional theory reference results for a wide range of observable properties, including crystal, liquid, and amorphous bulk phases, as well as point, line, and plane defects. We demonstrate that this new potential enables calculations that would be extremely expensive with a first principles electronic structure method, such as finite temperature phase boundary lines, self-diffusivity in the liquid, formation of the amorphous by slow quench, and dynamic brittle fracture. We show that the uncertainty quantification inherent to the Gaussian process regression framework gives a qualitative estimate of the potential's accuracy for a given atomic configuration. The success of this model shows that it is indeed possible to create a useful machine-learning-based interatomic potential that comprehensively describes a material, and serves as a template for the development of such models in the future.
MicroRNAs and Sepsis-Induced Cardiac Dysfunction: A Systematic Review

Sepsis is a severe condition characterized by systemic inflammation. One of the most involved organs in sepsis is the heart. On the other hand, heart failure and dysfunction are some of the most leading causes of death in septic patients. miRNAs are short single-strand non-coding ribonucleic acids involved in the regulation of gene expression on a post-transcriptional phase, which means they are a part of the epigenetic process. Recently, researchers have found that miRNA expression in tissues and blood differs depending on different conditions. Because of this property, their use as serum sepsis biomarkers has also been explored. A narrative review is carried out to gather and summarize what is known about miRNAs’ influence on cardiac dysfunction during sepsis. When reviewing the literature, we found at least 77 miRNAs involved in cardiac inflammation and dysfunction during sepsis. In the future, miRNAs may be used as early sepsis-induced cardiac dysfunction biomarkers or as new drug targets. This could help clinicians to early detect, prevent, and treat cardiac damage. The potential role of miRNAs as new diagnostic tools and therapeutic strategies worth deepening the complex network between non-coding RNA and biological pathways. Additional studies are needed to further investigate their role in sepsis-induced myocardium injury.
Regulation of Serum Exosomal MicroRNAs in Mice Infected with Orientia tsutsugamushi

Exosomes are small extracellular vesicles that carry proteins, lipids, and nucleic acids. They are circulated in many body fluids and play an important role in intercellular communications. MicroRNAs (miRNAs), as major components of exosomes, are often regulated in many diseases including bacterial and viral infections. Functionally, exosome-carried miRNAs interact with various immune cells and affect their behavior. Little is known whether exosomal miRNAs are regulated during scrub typhus, a potentially lethal infection caused by intracellular bacteria, Orientia tsutsugamushi. In the present study, we utilized a scrub typhus mouse model and collected serum at various time points post infection. A custom quantitative PCR array covering 92 murine miRNAs was used to profile serum exosomal miRNAs. A total of 12 miRNAs were found to be significantly up- or down-regulated at least at one time point post infection when compared to uninfected animals. Further analysis identified multiple miRNAs in the let-7 family that were consistently down-regulated at early and late phase of infection. Functionally, serum exosomes isolated from infected mice displayed strong proinflammatory effect when incubated with bone marrow-derived macrophages. Our data revealed dynamic regulations of serum exosomal miRNA during scrub typhus infection, which could significantly influence host immune responses and disease outcome.
Centaurin-likeproteinCnt 5 contributes toarsenic and cadmium resistance in ¢ ssionyeast

Arsenic (As) and cadmium (Cd) are two of the most hazardous substances in the environment and have been implicated in a number of human diseases including cancer. Their mechanisms of toxicity and subsequent carcinogenesis are not understood. To identify the genes involved in As/Cd detoxification, we screened a random insertional mutagenesis library of Schizosaccharomyces pombe for mutants that are hypersensitive to As/Cd. Mutations were mapped to spc1 (sty1) and SPBC17G9.08c. Spc1 is a stress-activated protein kinase orthologous to human p38. A fragment of SPBC17G9.08c was previously identified as csx2, a high-copy suppressor of cut6 that encodes an acetyl-CoA carboxylase involved in fatty acid biosynthesis. SPBC17G9.08c is a member of the centaurin ADP ribosylation factor GTPase activating protein family found in a variety of fungi, plants and metazoans, but not in Saccharomyces cerevisiae. Cnt5, so named because its closest human homolog is centaurin b-5, binds to phosphatidic acid and phosphatidyl serine in vitro. Microscopic localization of Cnt5-GFP indicates significant redistribution of Cnt5 from the cytoplasm to the cell membranes in response to As stress. These data suggest a model in which Cnt5 contributes to As/Cd resistance by maintaining membrane integrity or by modulating membrane trafficking.
The Interactions of Nintedanib and Oral Anticoagulants—Molecular Mechanisms and Clinical Implications

Nintedanib is a synthetic orally active tyrosine kinase inhibitor, whose main action is to inhibit the receptors of the platelet-derived growth factor, fibroblast growth factor and vascular endothelial growth factor families. The drug also affects other kinases, including Src, Flt-3, LCK, LYN. Nintedanib is used in the treatment of idiopathic pulmonary fibrosis, chronic fibrosing interstitial lung diseases and lung cancer. The mechanism of action suggests that nintedanib should be considered one of the potential agents for inhibiting and revising the fibrosis process related to COVID-19 infections. Due to the known induction of coagulation pathways during COVID-19 infections, possible interaction between nintedanib and anticoagulant seems to be an extremely important issue. In theory, nintedanib could increase the bleeding risk, thrombosis and lead to thrombocytopenia. The data from clinical trials on the concomitant use of nintedanib and antithrombotic agents is very limited as this patient group was within the standard exclusion criteria. Nintedanib is an important therapeutic option, despite its interaction with anticoagulants. If anticoagulant therapy is necessary, the more effective and safer option is the concomitant administration of DOACs and nintedanib, especially when drug-monitored therapy will be used in patients at high risk of bleeding complications.
Water resources assessment in a poorly gauged mountainous catchment using a geographical information system and remote sensing

Water resources assessment, which is an essential task in making development plans managing water resources, is considerably difficult to do in a data‐poor region. In this study, we attempted to conduct a quantitative water resources assessment in a poorly gauged mountainous catchment, i.e. the River Indrawati catchment (1233 km2) in Nepal. This catchment is facing problems such as dry‐season water scarcity and water use conflicts. However, the region lacks the basic data that this study needs. The data needed are supplemented from field surveys and global data (e.g. GTOPO30 DEM data, LandsatTM data and MODIS NDVI data). The global data have significantly helped us to draw out the information needed for a number of water‐use scenarios. These data helped us determine that the available water quantity is enough at present to address the dry‐season problems. The situation is not much worse for the immediate future; however, the threat of drought is noticed in a future scenario in which resources are consumed extensively. The study uses a geographical information system and remotely sensed data analysis tools extensively. Utilization of modern tools and global data is found effective for investigating practical problems and for detecting important features of water resources, even though the catchment is poorly gauged. Copyright © 2004 John Wiley & Sons, Ltd.
Meta-Wearable Antennas—A Review of Metamaterial Based Antennas in Wireless Body Area Networks

Wireless Body Area Network (WBAN) has attracted more and more attention in many sectors of society. As a critical component in these systems, wearable antennas suffer from several serious challenges, e.g., electromagnetic coupling between the human body and the antennas, different physical deformations, and widely varying operating environments, and thus, advanced design methods and techniques are urgently needed to alleviate these limitations. Recent developments have focused on the application of metamaterials in wearable antennas, which is a prospective area and has unique advantages. This article will review the key progress in metamaterial-based antennas for WBAN applications, including wearable antennas involved with composite right/left-handed transmission lines (CRLH TLs), wearable antennas based on metasurfaces, and reconfigurable wearable antennas based on tunable metamaterials. These structures have resulted in improved performance of wearable antennas with minimal effects on the human body, which consequently will result in more reliable wearable communication. In addition, various design methodologies of meta-wearable antennas are summarized, and the applications of wearable antennas by these methods are discussed.
Brandisianones F and G from Millettia brandisiana Kurz and their cytotoxicity

Abstract A new flavanone and a new chalcone, brandisianones F and G, were purified from the roots of Millettia brandisiana Kurz, moreover, sixteen known compounds were found. The chemical structures of all isolated compounds were identified using spectroscopic methods including 1D-NMR, 2D-NMR, MS, IR and CD data. Chalcone 15 exhibited the most cytotoxic activity against liver cancer, HepG2, and cholangiocarcinoma, KKU-M156, cell lines with IC50 values of 1.74 ± 0.91 and 1.95 ± 0.95 µg/mL, respectively. Chalcones 2, 14, 16 and 18 as well as flavones 5, 6 and 12 showed moderate cytotoxicity with IC50 values ranging from 5.39 to 14.00 µg/mL.
Cellulose Derived Graphene/Polyaniline Nanocomposite Anode for Energy Generation and Bioremediation of Toxic Metals via Benthic Microbial Fuel Cells

Benthic microbial fuel cells (BMFCs) are considered to be one of the eco-friendly bioelectrochemical cell approaches nowadays. The utilization of waste materials in BMFCs is to generate energy and concurrently bioremediate the toxic metals from synthetic wastewater, which is an ideal approach. The use of novel electrode material and natural organic waste material as substrates can minimize the present challenges of the BMFCs. The present study is focused on cellulosic derived graphene-polyaniline (GO-PANI) composite anode fabrication in order to improve the electron transfer rate. Several electrochemical and physicochemical techniques are used to characterize the performance of anodes in BMFCs. The maximum current density during polarization behavior was found to be 87.71 mA/m2 in the presence of the GO-PANI anode with sweet potato as an organic substrate in BMFCs, while the GO-PANI offered 15.13 mA/m2 current density under the close circuit conditions in the presence of 1000 Ω external resistance. The modified graphene anode showed four times higher performance than the unmodified anode. Similarly, the remediation efficiency of GO-PANI was 65.51% for Cd (II) and 60.33% for Pb (II), which is also higher than the unmodified graphene anode. Furthermore, multiple parameters (pH, temperature, organic substrate) were optimized to validate the efficiency of the fabricated anode in different environmental atmospheres via BMFCs. In order to ensure the practice of BMFCs at industrial level, some present challenges and future perspectives are also considered briefly.
Thermal Expansion Model of Cement paste and Concrete Considering Micro-Structural Changes under Elevated Temperature

The expansion of concrete subjected to extreme elevated temperature is linked with intricate micro-structural variations, such as the transformation of the constituent phases. This study proposes a model to predict the thermal expansion of cement paste and concrete considering micro-structural changes under elevated temperatures ranging from 20°C to 800°C. The model presented can consider characteristics of various aggregates in the calculation of thermal expansion for concrete. The model is a combination of a multi-scale stoichiometric model and a multi-scale composite model. At the cement paste level, the model satisfactorily predicted a test result. At concrete level, upper bounds from the model were matched relatively well with test results by previous researcher. If the mechanical properties, such as elastic modulus (E), Poisson’s ratio (ν), and thermal deformation, of the aggregates used in concrete are given, it is likely that the model will reasonably predict experimental results.
Optimisation of device clocking schemes to minimise the effects of radiation damage in charge-coupled devices

The ESA Euclid mission aims to answer the question of how the universe originated through the mapping of the dark Universe. One method to investigate this geometry is to measure subtle changes in ellipticity using image sensors such as the CCD. However, the radiation environment in space plays a major part in the performance of CCD-based camera systems. When placed in space, a CCD becomes damaged by the radiation environment and this can lead to a ‘smearing’ of the charge, acting to change the ellipticity and therefore one must be able to separate the changes in ellipticity caused by radiation damage from those the mission aims to measure. To this end, the radiation damage induced shape changes require in depth investigation such that optimised operation can be achieved. A Monte Carlo simulation is being used to predict this impact, backed by experimental data from a detector formerly baselined for the mission. During the experimental study, an investigation was undertaken into the serial readout of the CCD to demonstrate an approach towards performance optimisation through a consideration of the trap species involved. A change in clocking scheme was found to result in a factor of three reduction in Charge Transfer Inefficiency.
Teachers’ perspectives of what works: Implementation of AT for students with disabilities

ABSTRACT Assistive technology (AT) can be used to support the academic and social development of students with disabilities in the classroom. This research asked teachers of students with disabilities to share the elements that they report as being necessary for the successful implementation of assistive technology they have available in their classrooms. The teachers reported on their successful experiences. There has been a great deal of research in the appropriate selection of devices to suit the needs of the individual student and their environment. While the successful implementation and incorporation of the AT into the classroom have been researched, it has emerged from this research that teachers are not utilizing commonly identified implementation checklists/processes. A number of key successful elements were identified, such as training, time to plan and respond, using AT effectively, the effort/experience of the teacher, and external support available. Each of these elements is discussed along with suggestions for a simplified implementation process. It should be noted that specific disabilities and assistive technologies were not a focus of the study. Future directions for research in the area of AT implementation are indicated.
Safety and efficacy of intravenous hydralazine and labetalol for the treatment of asymptomatic hypertension in hospitalised patients: A systematic review

Current guidelines for the management of asymptomatic hypertension (HTN) in the inpatient setting recommend the use of oral antihypertensives. However, in clinical practice, intravenous (IV) antihypertensives are commonly utilised with little supporting evidence. The objective of this study was to evaluate literature examining the safety/efficacy of IV hydralazine and labetalol in hospitalised patients with non‐emergent, asymptomatic HTN.
Epidemiological Challenges in Rare Bleeding Disorders: FVIII Inhibitor Incidence in Haemophilia A Patients—A Known Issue of Unknown Origin

There is a broad range of factor products approved in Germany for haemophilia A treatment. Since the introduction of recombinant coagulation factor VIII (FVIII) products in the 1990s, there has been substantial debate whether there is a difference in inhibitor incidence between single FVIII products or product classes. Neither haemophilia registries nor clinical studies, including a randomised controlled clinical trial, provided a consistent and definite answer. The reasons were mainly related to methodological challenges in conducting controlled studies in a rare disease. In this analysis, the most relevant epidemiological challenges and main problems were examined, including study bias, potential overlap of individual studies and advanced development of therapy and methods in the course of time. Meta-analyses on two levels showed that therapies using recombinant products resulted in different event rates when compared to plasma-derived products. These results are accompanied by substantial study heterogeneity evidenced by Cochran’s Q tests. Only three studies have been identified that meet the standards of current clinical guidance. To finally resolve this ongoing and disputable safety issue of replacement therapy, collaboration among registry owners, academia and regulators must be fostered.
Click Chemistry Enabling Covalent and Non-Covalent Modifications of Graphene with (Poly)saccharides

Graphene is a material with outstanding properties and numerous potential applications in a wide range of research and technology areas, spanning from electronics, energy materials, sensors, and actuators to life-science and many more. However, the insolubility and poor dispersibility of graphene are two major problems hampering its use in certain applications. Tethering mono-, di-, or even poly-saccharides on graphene through click-chemistry is gaining more and more attention as a key modification approach leading to new graphene-based materials (GBM) with improved hydrophilicity and substantial dispersibility in polar solvents, e.g., water. The attachment of (poly)saccharides on graphene further renders the final GBMs biocompatible and could open new routes to novel biomedical and environmental applications. In this review, recent modifications of graphene and other carbon rich materials (CRMs) through click chemistry are reviewed.
A deafness-associated tRNA mutation caused pleiotropic effects on the m1G37 modification, processing, stability and aminoacylation of tRNAIle and mitochondrial translation

Abstract Defects in the posttranscriptional modifications of mitochondrial tRNAs have been linked to human diseases, but their pathophysiology remains elusive. In this report, we investigated the molecular mechanism underlying a deafness-associated tRNAIle 4295A>G mutation affecting a highly conserved adenosine at position 37, 3′ adjacent to the tRNA’s anticodon. Primer extension and methylation activity assays revealed that the m.4295A>G mutation introduced a tRNA methyltransferase 5 (TRMT5)-catalyzed m1G37 modification of tRNAIle. Molecular dynamics simulations suggested that the m.4295A>G mutation affected tRNAIle structure and function, supported by increased melting temperature, conformational changes and instability of mutated tRNA. An in vitro processing experiment revealed that the m.4295A>G mutation reduced the 5′ end processing efficiency of tRNAIle precursors, catalyzed by RNase P. We demonstrated that cybrid cell lines carrying the m.4295A>G mutation exhibited significant alterations in aminoacylation and steady-state levels of tRNAIle. The aberrant tRNA metabolism resulted in the impairment of mitochondrial translation, respiratory deficiency, decreasing membrane potentials and ATP production, increasing production of reactive oxygen species and promoting autophagy. These demonstrated the pleiotropic effects of m.4295A>G mutation on tRNAIle and mitochondrial functions. Our findings highlighted the essential role of deficient posttranscriptional modifications in the structure and function of tRNA and their pathogenic consequence of deafness.