Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of clinical, pathological and genetic indicators in chickens with thiram-induced tibial dyschondroplasia

Tibial dyschondroplasia (TD) is one of the most common leg problems disease in fast-growing birds in the poultry industry. However, no systematic study on the changes in performance indicators of TD chickens during different periods of development has been performed. A total 200 broiler chicks were randomly divided into two equal groups: the normal group and the TD group (induce with 50 mg/kg thiram). After the induction of TD, the mortality rate, performance indicators, tibia bone indicators, physiological index changes in the serum, and gene and protein expression levels in the growth plate were examined. The results showed that the mortality and feed conversion ratio were higher in the TD group than in the normal group. The length, width and weight of the tibia were of low quality in TD chickens, while the width of the tibial growth plate was significantly enlarged (P < 0.05) in the TD group, especially on day 14 post-hatch. The levels of superoxide dismutase (SOD), total antioxidant capacity (T-AOC), glutathione peroxidase (GSH-Px), and alkaline phosphatase (ALP) were significantly decreased, while the levels of malondialdehyde (MDA), were significantly increased in TD chickens compared to normal chickens. Gene expression and western blotting analysis revealed up-regulation of Hsp90 and VEGF expression and down-regulation of Wnt4 expression in TD chickens compared to those in normal chickens. This systemic study compare clinical, pathological and genetic indicators in thiram-induced tibial dyschondroplasia and normal chickens during different age periods, which reveals new targets for the clinical diagnosis and prevention of TD in broiler chickens. www.impactjournals. com/oncotarget/ Oncotarget, Advance Publications 2017
Non-Overlapping Domain Decomposition Methods Interpreted as Multiplicative Subspace Correction Algorithms

We interprete non-overlapping domain decomposition methods as multiplicative subspace correction algorithms in the framework of Xu [8]. This allows us to estimate the effects of the perturbation which is created by an inexact solution of the problems on the subdomains that must be solved in each iteration. The general results are applied to finite element discretizations of the Poisson and Stokes equations.
Hexokinase-II Inhibition Synergistically Augments the Anti-tumor Efficacy of Sorafenib in Hepatocellular Carcinoma

This study aimed to examine whether inhibition of hexokinase (HK)-II activity enhances the efficacy of sorafenib in in-vivo models of hepatocellular carcinoma (HCC), and to evaluate the prognostic implication of HK-II expression in patients with HCC. We used 3-bromopyruvate (3-BP), a HK-II inhibitor to target HK-II. The human HCC cell line was tested as both subcutaneous and orthotopic tumor xenograft models in BALB/c nu/nu mice. The prognostic role of HK-II was evaluated in data from HCC patients in The Cancer Genome Atlas (TCGA) database and validated in patients treated with sorafenib. Quantitative real-time PCR, western blot analysis, and immunohistochemical staining revealed that HK-II expression is upregulated in the presence of sorafenib. Further analysis of the endoplasmic reticulum-stress network model in two different murine HCC models showed that the introduction of additional stress by 3-BP treatment synergistically increased the in vivo/vitro efficacy of sorafenib. We found that HCC patients with increased HK-II expression in the TCGA database showed poor overall survival, and also confirmed similar results for TCGA database HCC patients who had undergone sorafenib treatment. These results suggest that HK-II is a promising therapeutic target to enhance the efficacy of sorafenib and that HK-II expression might be a prognostic factor in HCC.
The Impact of Mobile Phones on Plastic Surgery and Burn Management

Mobile phones have progressively become an inseparable partner to plastic surgeons in their clinical practice. From using the mobile phone camera to take pictures of injuries and sending those for instant advice to searching for the best evidence articles in peer reviewed journals, mobile phones have changed the plastic surgeons' approach on the best way to manage their patients. The availability of information in mobile technology has allowed a growing market for education tools for plastic surgeons and patients, and the use of social media for marketing purposes. With the increased availability of smartphone applications, these devices have become an invaluable tool for the modern plastic surgeon.
Noninvasive Glucose Measurement for Diabetes Mellitus Patients

Diabetes mellitus, commonly known as diabetes is a chronic disease in which the body cannot produce enough insulin or cannot use the insulin. Without insulin, the body cannot regulate blood sugar and this causes high glucose levels in blood [1]. Raised glucose levels can cause some permanent damages in tissues and organs. For this reason, people with diabetes need to regularly measure their blood sugar levels and inject the necessary amount of insulin to their body.
Umbilical cord blood Erythropoietin as a biomarker of subacute and chronic hypoxia in deliveries complicated by meconium stained amniotic fluid

Background: The presence of meconium stained amniotic fluid (MSAF) during labour is often associated with a lot of adverse outcomes and historically has been considered to be a predictor of bad neonatal outcome. It is associated with fetal hypoxia and leads to emergency C/S, instrumental vaginal delivery for fetal distress, low Apgar score at birth, meconium aspiration syndrome and neuro-developmental handicaps. Umbilical cord serum erythropoietin levels have been claimed to be elevated in response to fetal hypoxia. Objective: To evaluate the umbilical cord serum erythropoietin levels in neonates born through MSAF and to determine whether it is influenced by gestational age. Study Design: Prospective case control study. Materials & Methods: Women with term uncomplicated singlet on pregnancies at gestational age between (37-41 +6 ) weeks admitted to the labour room in the active phase of labour were enrolled to participate in this study. The studied population has been divided into two groups, women with thick meconium stained amniotic fluid (study group) and women with clear amniotic fluid (control group). Umbilical cord serum Erythropoietin levels will be measured for both groups by ELISA, after delivery and Apgar score will be assessed for neonates of both groups then statistical analysis will be performed. Results: A significant relationship was found between MSAF and elevated umbilical cord serum erythropoietin levels since the p value was P < 0.001. Apgar score was lower significantly after 1 minute in study group, but lower none significantly after 5 minutes, as P <0.001and 0.109 respectively. Conclusions: The elevated umbilical cord serum Erythropoietin levels in neonates born through MSAF suggest subacute or chronic fetal Hypoxia, independent of gestational age.
EVALUATION AND COMPARISION OF ANTI PARKINSON ACTIVITY OF METHANOLIC EXTRACT OF Phaseolus vulgaris WITH L-DOPA

Evaluation of Anti Parkinson Activity of Phaseolus vulgaris in various Experimental Models. Powdered of Phaseolus vulgaris seeds were taken for preparation of methanolic extracts using percolators. The phytochemical tests such as TLC and taken spectra in UV visible spectrophotometer were performed for L-DOPA. Various experimental models were performed as In vivo, viz., haloperidol induced catalepsy in rat and chlorpromazine induced catalepsy in rat. Cataleptic scores were measured and compared with standard & disease control group. The study revealed that in all the Parkinson models, after 60 minute, the cataleptic score was found significantly lesser compared to Disease control group (where p<0.05) and after 120 minutes, the cataleptic scores were found more significantly reduced compared to Disease control group. From the findings of the performed models we can conclude that Methanolic extract of Phaseolus vulgaris shows anti-parkinson activity and might be useful as a better and safer herbal alternate for management of Parkinsonism.
Confinement Effect of Micro- and Mesoporous Materials on the Spectroscopy and Dynamics of a Stilbene Derivative Dye

Micro- and mesoporous silica-based materials are a class of porous supports that can encapsulate different guest molecules. The formation of these hybrid complexes can be associated with significant alteration of the physico-chemical properties of the guests. Here, we report on a photodynamical study of a push–pull molecule, trans-4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran (DCM), entrapped within faujasite-type zeolites (HY, NaX, and NaY) and MCM-41 in dichloromethane suspensions. The complex formation gives rise to caged monomers and H- and J-aggregates. Steady-state experiments show that the nanoconfinement provokes net blue shifts of both the absorption and emission spectra, which arise from preferential formation of H-aggregates concomitant with a distortion and/or protonation of the DCM structure. The photodynamics of the hybrid complexes are investigated by nano- to picosecond time-resolved emission experiments. The obtained fluorescence lifetimes are 65–99 ps and 350–400 ps for H- and J-aggregates, respectively, while those of monomers are 2.46–3.87 ns. Evidences for the presence of a charge-transfer (CT) process in trapped DCM molecules (monomers and/or aggregates) are observed. The obtained results are of interest in the interpretation of electron-transfer processes, twisting motions of analogues push–pull systems in confined media and understanding photocatalytic mechanisms using this type of host materials.
The accessory obturator nerve: an anatomical study with literature analysis

Objectives: The accessory obturator nerve (AON) is often underrepresented in the literature and unknown to many surgeons. As this variant nerve has been mistaken for other regional nerves e.g., obturator nerve, nerve injury has occurred. Therefore, the current study was undertaken to better understand the surgical anatomy of the AON. Methods: In the supine position, 20 adult fresh frozen cadavers (40 sides) underwent an anterior approach to the retroperitoneal space. When present, the length and diameter of the AON were measured with microcalipers. The position, course and origin of each AON were documented. Results: The AON was identified on 12 sides (30%). The origin was found to be L2–L3 on four sides; L3 on two sides, L3–L4 from three sides, from the obturator nerve on two sides, and from the femoral nerve on three sides. The average length from the origin to the superior pubic ramus was 14.5 cm. The average diameter was found to be 1.2 mm. All AON were found to lie medial to the psoas major muscle. Additionally, on all sides, the AON was medial to the femoral nerve and lateral to the obturator nerve. Two left sides anastomosed with the anterior division of obturator nerve at its exit from the obturator foramen. Eight sides terminated deep (two) or superficial (six) to the origin of pectineus; two of these had demonstrable branches to the hip joint. Conclusion: The AON is a normal anatomical variant and there are many variations in its origin and terminal branches can be “strong” or “weak. ” Knowing the normal anatomy and variations of the AON is important for surgeons including neurosurgeons, orthopaedic surgeons, and urologists who deal with the pathologies of this area.
Dynamic physiological temperature and pressure sensing with phase-resolved low-coherence interferometry

We report the development and characterisation of highly miniaturised fibre-optic sensors for simultaneous pressure and temperature measurement, and a compact interrogation system with a high sampling rate. The sensors, which have a maximum diameter of 250 µm, are based on multiple low-finesse optical cavities formed from polydimethylsiloxane (PDMS), positioned at the distal ends of optical fibres, and interrogated using phase-resolved low-coherence interferometry. At acquisition rates of 250 Hz, temperature and pressure changes of 0.0021 °C and 0.22 mmHg are detectable. An in vivo experiment demonstrated that the sensors had sufficient speed and sensitivity for monitoring dynamic physiological pressure waveforms. These sensors are ideally suited to various applications in minimally invasive surgery, where diminutive lateral dimensions, high sensitivity and low manufacturing complexities are particularly valuable.
ANTI-ANAEMIC ACTIVITY OF HYDRO-ALCOHOLIC LEAF EXTRACT OF LUFFA AEGYPTIACA IN PHENYLHYDRAZINE INDUCED ANEMIC RATS

The main aim of the current study is to determine the anti-anaemic activity in hydro-alcoholic leaf extract of Luffa aegyptiaca in phenylhydrazine induced anemic rats. Phenylhydrazine (60mg/kg) was administered intraperitoneally in rats for 2 days to induce anemia. The animals were divided into 5 groups containing 6 animals each. 1 st group was served as normal control group, 2 nd group was served as anaemic control administered with phenylhydrazine for two days, 3 rd group was served as standard reference control administered with Vitamin B 12 complex, 4 th group was served as test control administered with 100 mg/kg of hydro-alcoholic leaf extract of Luffa aegyptiaca and 5 th group was served as test control administered with 200mg/kg of hydro-alcoholic leaf extract of Luffa aegyptica . All the test drugs were given for 28 days daily through oral route. On 29 th day blood was withdrawn, through tail puncture and subjected to the determination of RBC, Hb and percentage Haematocrit. Both the hydro-alcoholic leaf extract of Luffa aegyptiaca and Vit. B 12 significantly increase the HB, RBC & % HCT level which indicates that Luffa aegyptiaca leaf exhibits’ the anti-anaemic activity.
Red and Processed Meat and Mortality in a Low Meat Intake Population

Associations of low-to-moderate consumption of red and processed meat with mortality would add to the evidence of possible adverse effects of these common foods. This study aims to investigate the association of red and processed meat intake with mortality. The Adventist Health Study-2 (AHS-2) is a prospective cohort study of ~96,000 Seventh-day Adventist men and women recruited in the US and Canada between 2002 and 2007. The final analytic sample after exclusions was 72,149. Cox proportional hazards regression was used and hazard ratios (HR) and confidence intervals (CI) were obtained. Diet was assessed by a validated quantitative food frequency questionnaire (FFQ), calibrated using six 24-h dietary recalls. Mortality outcome data were obtained from the National Death Index. During a mean follow-up of 11.8 years, there were 7961 total deaths, of which 2598 were Cardiovascular diseases (CVD) deaths and 1873 were cancer deaths. Unprocessed red meat was associated with risk of all-cause mortality (HR: 1.18; 95% CI: 1.07–1.31) and CVD mortality (HR: 1.26; 95% CI: 1.05–1.50). Processed meat alone was not significantly associated with risk of mortality. The combined intake of red and processed meat was associated with all-cause mortality (HR: 1.23; 95% CI: 1.11–1.36) and CVD mortality (HR: 1.34; 95% CI: 1.12–1.60). These findings suggest moderately higher risks of all-cause and CVD mortality associated with red and processed meat in a low meat intake population.
A Hypothetical Model Concerning How Spike-Timing-Dependent Plasticity Contributes to Neural Circuit Formation and Initiation of the Critical Period in Barrel Cortex

Spike timing is an important factor in the modification of synaptic strength. Various forms of spike timing-dependent plasticity (STDP) occur in the brains of diverse species, from insects to humans. In unimodal STDP, only LTP or LTD occurs at the synapse, regardless of which neuron spikes first; the magnitude of potentiation or depression increases as the time between presynaptic and postsynaptic spikes decreases. This from of STDP may promote developmental strengthening or weakening of early projections. In bidirectional Hebbian STDP, the magnitude and the sign (potentiation or depression) of plasticity depend, respectively, on the timing and the order of presynaptic and postsynaptic spikes. In the rodent barrel cortex, multiple forms of STDP appear sequentially during development, and they contribute to network formation, retraction, or fine-scale functional reorganization. Hebbian STDP appears at L4-L2/3 synapses starting at postnatal day (P) 15; the synapses exhibit unimodal “all-LTP STDP” before that age. The appearance of Hebbian STDP at L4-L2/3 synapses coincides with the maturation of parvalbumin-containing GABA interneurons in L4, which contributes to the generation of L4-before-L2/3 spiking in response to thalamic input by producing fast feedforward suppression of both L4 and L2/3 cells. After P15, L4-L2/3 STDP mediates fine-scale circuit refinement, essential for the critical period in the barrel cortex. In this review, we first briefly describe the relevance of STDP to map plasticity in the barrel cortex, then look over roles of distinct forms of STDP during development. Finally, we propose a hypothesis that explains the transition from network formation to the initiation of the critical period in the barrel cortex.
Psychomotor group therapy for demented patients in the nursing home

PSYCHOMOTOR THERAPY IN PSYCHO GERIATRICS We define psychomotor therapy as the treatment of people who are confronted with psychosocial problems, using movement activities and/or special attention for bodily experiences (Vermeer and Sonius, 1976; Fahrenfort, 1986; van Coppenolle, 1989). Over the past twenty years, psychomotor therapy has developed rapidly in The Netherlands. As part of the psychosocial care offered in psychiatric hospitals, it is now a generally accepted and applied form of treatment.
Clinocopathological Features of Renal Cell Carcinoma seen at a Radiotherapy Centre in Ibadan, Nigeria

Renal cell carcinoma (RCC) is a rare but lethal disease that accounts for about 2-3% of all adult malignancies. Reports from developing countries indicate a rising incidence while studies in our environment are sparse. The aim of this study is to determine the prevalence, pattern of presentation and outcome of treatment of patients with RCC seen at the Radiotherapy Clinic of the University College Hospital Ibadan. A 25 year retrospective study of patients treated for RCC was conducted. Case file records were retrieved and information on patients’ socio demographic data, presentation pattern, histology, treatment received and outcome of treatment were extracted. A total of twenty four (24) patients were seen within this period. A higher percentage of patients were female (62.5%) while males accounted for only 37.5%. The mean patient age was 42.9 years. Hematuria, loin pain and flank mass accounted for 80%, 37.5% and 28% of the presenting complaints respectively. Only 12.5% of patients presented with the classic triad of hematuria, loin pain and flank mass. Majority of the patients (62.5%) presented with advanced metastatic diseases. The commonest site of metastasis was the spine (29.2%). About two-third (67%) of patients had surgery. All patients had radiotherapy; 50% to the primary sites, 37.5% to metastatic sites and 12.5% to both metastatic and primary sites. All patients who presented with metastasis had chemotherapy. Only 4 patients (17%) were disease-free at the end of the first year posttreatment while only 1 was reported dead. The rest were either lost to follow-up (42%) or referred for palliative care (25%) as a result of disease progression. Renal cell carcinoma is a rare malignancy in Nigeria and patients often present late. Physicians working in this region needs to have high index of suspicion to diagnose the disease early as the outcome of treatment in late cases is poor.
Using Visual Methodology: Social Work Student’s Perceptions of Practice and the Impact on Practice Educators

Practice learning within social work education plays a significant part in students’ educational journey. Little is understood about the emotional climate of placements. This paper presents a small scale qualitative study of 13 social work students’ perceptions of their relationship with a practice educator (PE) and 6 PEs perceptions of these emotional experiences. Visual methodology was employed over a two-phased research project: first social work students were asked to draw an image of what they thought practice education looked like; phase two used photo eliciation, and PEs were then asked to explore the meaning of these images. Results demonstrated social work students focused on their own professional discourse, the identity of PEs, power relationship and dynamics between themselves and PEs, the disjointed journey and practice education in its entirity. Whilst the PEs shared their personal views of practice education and reflected on this, both groups had a shared understanding of practice education including its values and frustrations.
Challenges experienced by postgraduate nursing students at a South African university

Background The increase in nurses enrolling in postgraduate programmes as well as the need to improve their completion requires academics to establish environments conducive for postgraduate studies. The challenges experienced during postgraduate studies have to be identified to establish conducive environments. Objective The objective of this study was to explore and describe the challenges experienced by postgraduate nursing students enrolled in postgraduate coursework and research programmes at a South African university. Methods An exploratory, descriptive and qualitative design was used. The study was contextual in nature. Purposive sampling was used. Fifteen honours, master’s and doctoral students participated in the study. Data were analysed through qualitative content analysis and measures to ensure trustworthiness, and ethical implementation of the study were implemented. Results Three themes with categories were identified, namely personal challenges (i.e. finances, employment, family and accommodation), academic and institutional challenges (i.e. workload and time constraints, contact sessions, subject information and assessment) and research-related challenges (i.e. information literacy, supervisory relationship and supervisory structure and process). Conclusion Institutional support addressing personal, academic and research-related challenges should be provided to enhance student experiences and completion.
Traduction et validation du Questionnaire sur l’engagement dans les activités signifiantes

Description. Peu d’outils sont disponibles en français pour mesurer l’engagement dans des activités signifiantes, au cœur de l’ergothérapie. But. Cette étude visait à traduire l’Engagement in Meaningful Activities Survey et, ensuite, à vérifier la validité convergente et la cohérence interne de la version française. Méthodologie. Une traduction renversée a d’abord été réalisée. Pour ensuite évaluer la validité convergente du Questionnaire sur l’engagement dans des activités signifiantes (QEAS), l’Indice de la qualité de vie et la Mesure des habitudes de vie modifiée (participation sociale) ont été complétés par 84 adultes de la population générale. La cohérence interne a été mesurée avec l’alpha de Cronbach. Résultats. Un meilleur engagement dans les activités signifiantes est significativement associé à une qualité de vie (r = 0,36; p = 0,001) et une satisfaction accrues envers la participation sociale (ρ = 0,40; p < 0,001). Le QEAS présente une bonne cohérence interne (∂ = 0,81). Conséquences. Le QEAS est un questionnaire valide qui permettra aux ergothérapeutes francophones de mieux comprendre l’engagement de leurs clients dans l’ensemble de leurs activités.