Miracle-dz/UniFAR-FTUs huggingface dataset:
Positive and negative mood states mediated the effects of psychological resilience on emotional stability among high school students during the COVID-19 pandemic

This study investigated the parallel mediating effects of positive and negative mood states on the relationship between psychological resilience and emotional stability among first- through third-year senior high school students in China during the challenges of the COVID-19 pandemic. Of 408 questionnaires distributed from April 11 to April 22, 2022, to students at a high school located in Changzhou, Jiangsu, China, 360 were completed correctly and analyzed using a cross-sectional study design. The questionnaire included items from the modified Chinese version of the Psychological Resilience Scale, the Profile of Mood States scale, and the Eysenck Personality Questionnaire Short Scale in Chinese, the latter to assess emotional stability. The mediating effects of mood states on the relationship between psychological resilience and emotional stability were explored by using structural equation modeling and bootstrapping methods. The results indicated that psychological resilience directly affected emotional stability but also indirectly affected emotional stability through the mediating effects of positive and negative mood states. The mediating effect of negative mood states was greater than that of positive mood states. This result differs from that of research conducted prior to the pandemic, which found that compared with the damage caused by negative moods to emotional stability, positive moods more strongly promoted emotional stability. Our findings indicate that high school officials in China should consider strengthening mental health support for students who are taking courses online during home quarantine.
Primary aldosteronism caused by a pI157S somatic KCNJ5 mutation in a black adolescent female with aldosterone-producing adenoma

Aldosterone-producing adenoma is a rare cause of hypertension in children. Only a limited number of cases of aldosterone-producing adenomas with somatic KCNJ5 gene mutations have been described in children. Blacks are particularly more susceptible to developing long-standing cardiovascular effects of aldosterone-induced severe hypertension. Somatic CACNA1D gene mutations are particularly more prevalent in black males whereas KCNJ5 gene mutations are most frequently present in black females. We present here a novel somatic KCNJ5 p.I157S mutation in an aldosterone-producing adenoma from a 16-year-old black female whose severe drug-resistant hypertension significantly improved following unilateral adrenalectomy. Prompt diagnosis of aldosterone-producing adenoma and early identification of gene mutation would enable appropriate therapy and significantly reduce cardiovascular sequelae.
Exercise as an Aging Mimetic: A New Perspective on the Mechanisms Behind Exercise as Preventive Medicine Against Age-Related Chronic Disease

Age-related chronic diseases are among the most common causes of mortality and account for a majority of global disease burden. Preventative lifestyle behaviors, such as regular exercise, play a critical role in attenuating chronic disease burden. However, the exact mechanism behind exercise as a form of preventative medicine remains poorly defined. Interestingly, many of the physiological responses to exercise are comparable to aging. This paper explores an overarching hypothesis that exercise protects against aging/age-related chronic disease because the physiological stress of exercise mimics aging. Acute exercise transiently disrupts cardiovascular, musculoskeletal, and brain function and triggers a substantial inflammatory response in a manner that mimics aging/age-related chronic disease. Data indicate that select acute exercise responses may be similar in magnitude to changes seen with +10–50 years of aging. The initial insult of the age-mimicking effects of exercise induces beneficial adaptations that serve to attenuate disruption to successive “aging” stimuli (i.e., exercise). Ultimately, these exercise-induced adaptations reduce the subsequent physiological stress incurred from aging and protect against age-related chronic disease. To further examine this hypothesis, future work should more intricately describe the physiological signature of different types/intensities of acute exercise in order to better predict the subsequent adaptation and chronic disease prevention with exercise training in healthy and at-risk populations.
Prediction of Mortality Risk After Ischemic Acute Kidney Injury With a Novel Prognostic Model: A Multivariable Prediction Model Development and Validation Study

Background and Objectives: Acute kidney injury (AKI) that results from ischemia is a common clinical syndrome and correlates with high morbidity and mortality among hospitalized patients. However, a clinical tool to predict mortality risk of ischemic AKI is not available. In this study, we aimed to develop and validate models to predict the 30-day and 1-year mortality risk of hospitalized patients with ischemic AKI. Methods A total of 1,836 admissions with ischemic AKI were recruited from 277,898 inpatients admitted to three affiliated tertiary general hospitals of Central South University in China between January 2015 and December 2015. Patients in the final analysis were followed up for 1 year. Study patients were randomly divided in a 7:3 ratio to form the training cohort and validation cohort. Multivariable regression analyses were used for developing mortality prediction models. Results Hepatorenal syndrome, shock, central nervous system failure, Charlson comorbidity index (≥2 points), mechanical ventilation, renal function at discharge were independent risk factors for 30-day mortality after ischemic AKI, while malignancy, sepsis, heart failure, liver failure, Charlson comorbidity index (≥2 points), mechanical ventilation, and renal function at discharge were predictors for 1-year mortality. The area under the receiver operating characteristic curves (AUROCs) of 30-day prediction model were 0.878 (95% confidence interval (CI): 0.849-0.908) in the training cohort and 0.867 (95% CI: 0.820–0.913) in the validation cohort. The AUROCs of the 1-year mortality prediction in the training and validation cohort were 0.803 (95% CI: 0.772–0.834) and 0.788 (95% CI: 0.741–0.835), respectively. Conclusion Our easily applied prediction models can effectively identify individuals at high mortality risk within 30 days or 1 year in hospitalized patients with ischemic AKI. It can guide the optimal clinical management to minimize mortality after an episode of ischemic AKI.
Human metapneumovirus M2-2 protein inhibits RIG-I signaling by preventing TRIM25-mediated RIG-I ubiquitination

Retinoic acid-inducible gene I (RIG-I) is a receptor that senses viral RNA and interacts with mitochondrial antiviral signaling (MAVS) protein, leading to the production of type I interferons and inflammatory cytokines to establish an antiviral state. This signaling axis is initiated by the K63-linked RIG-I ubiquitination, mediated by E3 ubiquitin ligases such as TRIM25. However, many viruses, including several members of the family Paramyxoviridae and human respiratory syncytial virus (HRSV), a member of the family Pneumoviridae, escape the immune system by targeting RIG-I/TRIM25 signaling. In this study, we screened human metapneumovirus (HMPV) open reading frames (ORFs) for their ability to block RIG-I signaling reconstituted in HEK293T cells by transfection with TRIM25 and RIG-I CARD (an N-terminal CARD domain that is constitutively active in RIG-I signaling). HMPV M2-2 was the most potent inhibitor of RIG-I/TRIM25-mediated interferon (IFN)-β activation. M2-2 silencing induced the activation of transcription factors (IRF and NF-kB) downstream of RIG-I signaling in A549 cells. Moreover, M2-2 inhibited RIG-I ubiquitination and CARD-dependent interactions with MAVS. Immunoprecipitation revealed that M2-2 forms a stable complex with RIG-I CARD/TRIM25 via direct interaction with the SPRY domain of TRIM25. Similarly, HRSV NS1 also formed a stable complex with RIG-I CARD/TRIM25 and inhibited RIG-I ubiquitination. Notably, the inhibitory actions of HMPV M2-2 and HRSV NS1 are similar to those of V proteins of several members of the Paramyxoviridae family. In this study, we have identified a novel mechanism of immune escape by HMPV, similar to that of Pneumoviridae and Paramyxoviridae family members.
The influence of blue light on sleep, performance and wellbeing in young adults: A systematic review

Introduction: Blue light from electronic devices has a bad reputation. It has a wavelength which may influence our circadian rhythm and cause bad sleep. But there are other aspects of blue light exposure which are often overlooked, for example, it may influence performance and wellbeing. However, few resources summarize its effects systematically. Therefore, the goal of this systematic review was to distil the present evidence on blue light exposure and its influence on sleep, performance and wellbeing and discuss its significance for athletes. Methods: The databases that were searched were Cochrane, Embase, Pubmed, Scopus, and Virtual Health Library. The studies included investigated the influence of blue light exposure on either sleep, performance, wellbeing or a combination of those parameters on healthy humans. Quality assessment was done based on the quantitative assessment tool “QualSyst. ” Results: Summarizing the influence of blue light exposure, the following results were found (expressed as proportion to the number of studies investigating the particular parameter): Fifty percent of studies found tiredness to be decreased. One fifth of studies found sleep quality to be decreased and one third found sleep duration to be decreased. Half of the studies found sleep efficacy to be decreased and slightly less than half found sleep latency to be increased. More than one half of the studies found cognitive performance to be increased. Slightly more than two thirds found alertness to be increased and reaction time to be decreased. Slightly less than half of the studies found wellbeing to be increased. Conclusion: Blue light exposure can positively affect cognitive performance, alertness, and reaction time. This might benefit sports reliant on team-work and decision-making and may help prevent injury. Blue light might also have negative effects such as the decrease in sleep quality and sleep duration, which might worsen an athlete’s physical and cognitive performance and recovery. Further research should explore if blue light can improve sleep, performance and wellbeing to significantly benefit athletic performance.
Some Improvements of Convergence Order of Finite Volume Solutions

In this article, we improve the convergence order of some finite volume solutions approximating some second order elliptic problems. We prove that finite volume approximations of order $O(h^{k+1})$, with $k$ integer, can be obtained after $k$ corrections, starting with finite volume solution of order $O(h)$, by using the same matrix and changing only the second member of the original system. This is done for general smooth second order elliptic problems in one dimension and for second order elliptic problems of the form $-\Delta u+pu=f$, with Dirichlet conditions. Numerical tests justifying theoretical results and showing the efficiency of the method are presented. The idea used behind these results is the one of Fox's difference correction in the context of finite difference method.
Biodegradability of bioplastic blown film in a marine environment

The waste created by single-use plastics is an important global issue, especially in marine environments, because they do not degrade in nature. This work aimed to study the biodegradability of bioplastic blown film, which may pose a solution to this problem. Polybutylene succinate (PBS) and polylactic acid (PLA) blown films were chosen for examination of their biodegradability when submerged in sand under the seawater and when floated on the seawater surface of our experimental setup. Bioplastics were observed in comparison with low-density polyethylene (LDPE), which is a petroleum-based plastic. PBS blown film exhibited a faster degradation rate than PLA blown film, while LDPE blown film did not degrade in the marine environment. The biodegradability of bioplastic blown film was confirmed by physical observation, a change in the chemical functional group measured by Fourier-transform infrared spectroscopy, and a test of the biochemical oxygen demand of the seawater after bioplastic degradation due to ingestion by bacteria in seawater.
Obligately aerobic human gut microbe expresses an oxygen resistant tungsten-containing oxidoreductase for detoxifying gut aldehydes

Brevibacillus massiliensis strain phR is an obligately aerobic microbe that was isolated from human feces. Here, we show that it readily takes up tungsten (W), a metal previously associated only with anaerobes. The W is incorporated into an oxidoreductase enzyme (BmWOR) that was purified from native biomass. BmWOR consists of a single 65 kDa subunit and contains a single W-pyranopterin cofactor and a single [4Fe-4S] cluster. It exhibited high aldehyde-oxidizing activity with very high affinities (apparent Km < 6 μM) for aldehydes common in the human gut and in cooked foods, including furfural, propionaldehyde, benzaldehyde and tolualdehyde, suggesting that BmWOR plays a key role in their detoxification. B. massiliensis converted added furfural to furoic acid when grown in the presence of W, but not in the presence of the analogous element molybdenum. B. massiliensis ferredoxin (BmFd) served as the electron acceptor (apparent Km < 5 μM) for BmWOR suggesting it is the physiological electron carrier. Genome analysis revealed a Fd-dependent rather than NADH-dependent Complex I, suggesting that WOR not only serves a detoxification role but its aldehyde substrates could also serve as a source of energy. BmWOR is the first tungstoenzyme and the first member of the WOR family to be obtained from a strictly aerobic microorganism. Remarkably, BmWOR oxidized furfural in the presence of air (21% O2, v/v) but only if BmFd was also present. BmWOR is the first characterized member of the Clade 83 WORs, which are predominantly found in extremely halophilic and aerobic archaea (Clade 83A), with many isolated from food sources, while the remaining bacterial members (Clade 83B) include both aerobes and anaerobes. The potential advantages for microbes found in foods and involved in human gut health that harbor O2-resistant WORs, including in Bacillus and Brevibacillus based-probiotics, are discussed.
Base-flow segmentation and character analysis of the Huangfuchuan Basin in the middle reaches of the Yellow River, China

In recent years, with the deterioration of the ecological environment, runoff in the Yellow River has been decreasing. Given these phenomena, it is necessary to research the base-flow segmentation methods and its characteristics. The Huangfuchuan Basin in the middle reaches of the Yellow River basin was selected as the research area. This paper calculated the base-flow with commonly used base-flow segmentation methods, including Base-flow index method (BFI), Hydrograph-separation techniques (HYSEP), and the digital filtering methods, and compared the applicability of these methods in the study area. Then the variation characteristics, abrupt change year, periodic change, and future trend of the base-flow were analyzed. The results are as follows: 1) Through the analysis and comparison of several common base-flow segmentation methods, these methods had a marked difference in base-flow segmentation. The variance and extreme-ratio of DF4 in the digital filtering methods were small. The correlation between DF4 and other methods was high. DF4 in the digital filtering methods was the most appropriate method in the research area. 2)The runoff and base-flow index presented a decreasing trend. The annual average runoff was 1,100.27 × 104 m3, and the maximum base-flow was 0.21. The base-flow also showed a significant decrease trend by the Mann-Kendall trend test, the average base-flow was 10,578.35 × 104 m3. 3) The base-flow had periodic variations of 3–6, 7–18, and 19–32. In the 19–32 years time scale, three oscillations alternated between abundant and dry. The whole time was 31 years as the center of the periodic change, the first primary cycle of base-flow change. 4) The base-flow mutation occurred in 1986. The Hurst index of base-flow in the Huangfuchuan Basin was 0.84. It was shown that the trend of future development is positively correlated with past change, showing a trend of continuous decrease. Selecting the appropriate method of base-flow segmentation and reasonably analyzing the variation characteristics of base-flow can provide scientific guidance for the ecological environment construction and water resource evaluation in the Huangfuchuan Basin and even the Yellow River Basin.
Prevalence and prognostic significance of hyponatremia in 1 lung cancer patients: Systematic Review and Meta- 2 Analysis 3

The prevalence of hyponatremia is highly variable among lung cancer patients. It is also 29 an important predictive factor, according to numerous studies. However, its prevalence and 30 prognostic significance in subgroups of lung cancer patients, e.g. in small cell and non-small 31 cell lung cancers (SCLC and NSCLC, respectively), have not yet been evaluated in a meta- 32 analysis. We report this systematic review and meta-analysis according to the Preferred 35 Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2009) Statement. We 36 have registered our meta-analysis and review’s protocol to the PROSPERO International 37 Prospective Register of Systematic Reviews, with the following registration number: 38 CRD42020167013. A systematic search was done in the following sources: MEDLINE, 39 Embase, CENTRAL, Web of Science, ClinicalTrials.gov, a WHO Global Health Library. We 40 extracted the effect measure for each outcome as the relative risk (RR) with the related 95% 41 confidence interval (CI). we in our varied and
Heritage Tagalog Phonology and a Variationist Framework of Language Contact

: Heritage language variation and change provides an opportunity to examine the interplay of contact-induced and language-internal effects while extending the variationist framework beyond monolingual speakers and majority languages. Using data from the Heritage Language Variation and Change in Toronto Project, we illustrate this with a case study of Tagalog (r), which varies between tap, trill, and approximant variants. Nearly 3000 tokens of (r)-containing words were extracted from a corpus of spontaneous speech of 23 heritage speakers in Toronto and 9 homeland speakers in Manila. Intergenerational and intergroup analyses were conducted using mixed-effects modeling. Results showed greater use of the approximant among second-generation (GEN2) heritage speakers and those that self-report using English more. In addition, the distributional patterns remain robust and the approximant appears in more contexts. We argue that these patterns reﬂect an interplay between internal and external processes of change. We situate these ﬁndings within a framework for distinguishing sources of variation in heritage languages: internal change, identity marking and transfer from the dominant language. = 2.20, p < 0.001) contexts. Both groups show that English loans favor the use of the approximant variant compared to Tagalog words, but this effect is bigger for low EO speakers ( Est . = 2.72, p < 0.001; high EO: Est. = 1.52, p < 0.001).
Modiﬁcation of Surface Hydrophobicity of PLA / PE and ABS / PE Polymer Blends by ICP Etching and CF x Coating

: The ﬂow regime inside the channel of 3D printed microreactors is deﬁned by the surface properties of the channel walls. Polylactide (PLA) and acrylonitrile / butadiene / styrene (ABS) are two polymers that are the most common in additive manufacturing using fused ﬁlament fabrication, commonly known as “3D printing”. With the aim of developing new materials for the 3D printing of microreactors whose channel surface hydrophobicity could be modiﬁed, PLA and ABS were blended with cheaper and widely used polymers-high-density polyethylene (PE-HD) and low-density polyethylene (PE-LD). Polymer blend surfaces were treated with inductively coupled plasma (ICP) and coated by ﬂuorocarbon-based material (CF x ) plasma deposition treatment in order to modify surface hydrophobicity. It has been shown that the modiﬁcation of surface morphology of PLA polymer blends can be achieved by ICP etching and CF x coating, while this was not possible for ABS polymer blends under the conducted treatment conditions. The treated surface of PLA / PE-HD 90 / 10 showed a contact angle of 121.6 ◦ which is 36 ◦ higher than the contact angle measured on the untreated surface. Surfaces that have achieved contact angles higher than 120 ◦ have an “island like” surface morphology. Samples with higher “islands” showed higher contact angles, that conﬁrmed that the hydrophobicity also depends on the height of the “islands”. Furthermore, it has been found that etching time signiﬁcantly impacts the contact angle values and surface morphology of the PLA polymer blends, while the CF x coating time does not have signiﬁcant impact on the surface properties. investigation, V.L. M. and D.V. ; resources, C.G. , M.T. and D.V. ; data curation, V.L. M. ; writing—original draft preparation, V.L. M. and D.V. ; writing—review and editing, I.G. and D.V. ; visualization, V.L. M. ; supervision, C.G. , M.T. and D.V. ; project administration, C.G. , M.T. and D.V. ; funding acquisition, I.G. , C.G. ,
Edinburgh Research Explorer Towards Low-Dimensionsal Proportional Myoelectric Control

—One way of enhancing the dexterity of powered myoelectric prostheses is via proportional and simultaneous control of multiple degrees-of-freedom (DOFs). Recently, it has been demonstrated that the reconstruction of ﬁnger movement is feasible by using features of the surface electromyogram (sEMG) signal. In such paradigms, the number of predictors and target variables is usually large, and strong correlations are present in both the input and output domains. Synergistic patterns in the sEMG space have been previously exploited to facilitate kinematics decoding. In this work, we propose a framework for simultaneous input-output dimensionality reduc- tion based on the generalized eigenvalue problem formulation of multiple linear regression (MLR). We demonstrate that the proposed methodology outperforms simultaneous input-output dimensionality reduction based on principal component analysis (PCA), while the prediction accuracy of the full rank regression (FRR) method can be achieved by using only a few relevant dimensions.
Microsoft Word-00809-Merged.docx

Drought poses a major environmental threat to maize (Zea mays) production worldwide. Since maize is a monoecious plant, maize grain yield is dependent on the synchronous development of male and female inflorescences. When a drought episode occurs during flowering, however, an asynchronism occurs in the anthesis and silking interval (ASI) that results in significant yield losses. The underlying mechanism responsible for this asynchronism is still unclear. Here, we obtained a © The Author(s) (2021) . Published by Oxford University Press on behalf of American Society of Plant Biologists. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contactjournals.permissions@oup.com D ow naded rom http/academ ic.p.com /plcell/advance-art.1093/plcell/koab083/6175065 by gest on 30 M arch 2021