Miracle-dz/UniFAR-FTUs huggingface dataset:
Geometric Accuracy Assessment of Very High-Resolution Optical Data Orthorectified using TerraSAR-X DSM to Support Disaster Management in Indonesia

Advanced remote sensing satellite data with detail spatial resolution can be an alternative to aerial photography and outweigh in providing rapid and vast spatial, remote area, and consist of multispectral bands to produce continues information. The various types of very high spatial resolution satellite, benefit in producing information for large-scale mappings, such as updating an urban map and supporting disaster management for mitigation, preparedness, emergency response, and recovery effectively and efficiently. Large-scale mapping information for disaster management, particularly for quick response is essential to map the impacted sites, measure the number of houses and infrastructure damaged and determine the evacuation area. However, in producing large-scale mapping, the information should refer to the geospatial specification standard, such as accurate geometric, detail thematic information and completeness. This study aims to identify the use of Pleiades imagery for supporting large-scale mapping, including for disaster management by assessing the geometry accuracy from a standard product acquired from the ground station and precise orthorectification using different types of DSM, including TerraSAR-X and improvement using ground control points. The results show that the improved accuracy to meet geometric accuracy standard for scale 1:5000 can be achieved using a primary product data which process using an insertion of GCPs and selecting the better DSM, while for the standard ortho product can be achieved using shifting the coordinate position of the image. Assessment of the thematic extraction visually shows that the imagery meets the information for large-scale mapping, but detail attribution requires information from field data.
UNIVERSITY STUDENTS’ SELF-EFFICACY IN THE SAFE USE OF THE INTERNET

The use of the Internet is increasing day by day by people, especially among the students, and most of the time this affects the students negatively. Hence, this research is aimed to investigate university students’ self-efficacy in the safe use of the Internet. Research based model and scale was used in the study where data were collected from 709 randomly chosen volunteered students. A scale was used to collect data in the study. The scale consisted of four dimensions with 35 items: Social networking sites, malicious software, web security and social engineering, and computer security. Descriptive statistics, frequency, percentage, one-way ANOVA and independent t -test were used to analyze the collected data. After statistical analysis of the collected data, the disheartened result was found that university students’ self-efficacy in the safe use of the Internet is not enough to protect themselves from harmful aspects of the Internet. There were also significant differences found in the overall mean average score of university students’ self-efficacy in the safe use of the internet between gender and age. From this study, it could be deduced that the results of the study will be valuable to students, parents and most probably to the people engaged in research at the government offices or at universities. By knowing the possible weakness of students’ self-efficacy in the safe use of the Internet issues, appropriate solutions can be proposed to help salvage this problem.
Relationship between IL-8, IL-10, MMP-9 level and morphological pattern of BAL fluid in interstitial lung diseases patients

There is an increasing evidence that imbalance between pro- and anti-inflammatory factors such as cytokines and proteases is able to direct course of inflammatory lung diseases. Possible relations between proinflammatory interleukin (IL) - 8 and proangiogenic metalloproteinase-9 (MMP-9) as well as antiinflammatory interleukin-10 in bronchoalveolar lavage fluid (BALf) of pulmonary sarcoidosis (BBS) (n=18), idiopathic pulmonary fibrosis (IPF) (n=10) and hypersensitivity pneumonitis (HP) (n=9) patients were examined. IL-8, IL-10 and MMP-9 concentrations in BAL supernatants were determined using ELISA test. A strong correlation (p<0.01) between concentration of IL-8 and MMP-9 in BALf of studied groups was found. Moreover, in IPF group the level of MMP-9 strongly correlated (p<0.01) with IL-10 as well as negatively with relative count of macrophages (p<0.05); while the relative count of neutrophils positively correlated with IL-10 (p<0.01) as well as MMP-9 (p<0.01). In BBS stage I group negative correlation between level of IL-10 and macrophages relative count (p<0.05) as well as positive correlation between IL10 and lymphocytes relative count (p<0.05) was present. Activity of MMPs and their close relationship with proinflammatory and antiinflammatory factors such IL-8 and IL-10 suggest the contribution of angiogenesis in pathogenesis of interstitial lung disease. Further studies should reveal more data concerning the possible therapeutic approach involving both antiinflammatory and antiangiogenic activities.
J C A P 0 7 ( 2 0 1 8 ) 0 3 1 ournal of C osmology and A stroparticle P hysics

We extend the public CppTransport code to calculate the statistical properties of fluctuations in multiple-field inflationary models with curved field space. Our implementation accounts for all physical effects at tree-level in the ‘in-in’ diagrammatic expansion. This includes particle production due to time-varying masses, but excludes scenarios where the curvature perturbation is generated by averaging over the decay of more than one particle. We test our implementation by comparing results in Cartesian and polar field-space coordinates, showing excellent numerical agreement and only minor degradation in compute time. We compare our results with the PyTransport 2.0 code, which uses the same computational approach but a different numerical implementation, finding good agreement. Finally, we use our tools to study a class of gelaton-like models which could produce an enhanced nonGaussian signal on equilateral configurations of the Fourier bispectrum. We show this is difficult to achieve using hyperbolic field-space manifolds and simple inflationary potentials.
The Quotient

The central role of the Rayleigh quotient in many body physics is discussed. Various many body methods can be obtained from either an attempt to evaluate the Rayleigh Quotient directly or through various variational approximations. Rather than dwell on the technical details necessary to obtain the equations of the various many body methods, we concentrate on how they can be obtained from the Rayleigh Quotient, and some of the consequences of the approximations involved in their evaluation.
Maximum Likelihood Estimation of State-Space Models

The use of the Kalman filter for estimation purposes is not always an easy task despite the obvious advantages in many situations of the state-space representation. This is in part due to the fact that the computation of the corresponding score (gradient of the log-likelihood) is sometimes complicated and numerically challenging. We present an algorithm for the exact construction of the score that is written in the form of explicit and ready to be used Markov type matrix recursions that are very efficient from the memory management point of view. As an example, this general result is applied to the estimation of ARMA models in state-space representation.
AIS Electronic Library (AISeL) AIS Electronic Library (AISeL) Are Live Streamers Similar or Different? Grid Typology Model of Are Live Streamers Similar or Different? Grid Typology Model of Live Streamers in E-commerce Live Streamers in E-commerce

: As a new type of consumption in the digital economy era, live streaming shopping has become popular among ecommerce consumers. The success of live streaming e-commerce is largely determined by the qualities of live streamers, and how to evaluate live streamers is a critical topic in e-commerce. Researchers have paid little attention to the complex nature of live streamers and mainly view them as salespersons. Furthermore, no efforts have been conducted to comprehensively identify their typology. To address these gaps, in this study examining live streamers simultaneously from the perspectives of salespersons and spokespersons is proposed. A Live Streamer Grid Typology Model is developed by assessing the qualities of live streamers in terms of their abilities as salespersons and spokespersons.
Review of the effectiveness of neuromuscular electrical stimulation in the treatment of dysphagia – an update

Background: Neuromuscular electrical stimulation (NMES) has been used as a treatment option in the therapy of dysphagia for several years. In a previous review of the literature, it was concluded that NMES might be a valuable adjunct in patients with dysphagia and in patients with vocal fold paresis. However, due to different stimulation protocols, electrode positioning and various underlying pathological conditions, it was difficult to compare the studies which were identified and it was concluded that more empirical data is needed to fully understand the benefits provided by NMES. The purpose of this systematic review is, therefore, to evaluate recent studies regarding a potential effectiveness of transcutaneous NMES applied to the anterior neck as a treatment for dysphagia considering these different aspects. Method: For this systematic review, a selective literature research in PubMed has been carried out on 5th May 2021 using the terms electrical stimulation AND dysphagia and screened for inclusion criteria by two reviewers in Rayyan. The search resulted in 62 hits. Results: Studies were excluded due to their publication language; because they did not meet inclusion criteria; because the topical focus was a different one; or because they did not qualify as level 2 studies. Eighteen studies were identified with varying patient groups, stimulation protocols, electrode placement and therapy settings. However, 16 studies have reported of beneficial outcomes in relation with NMES. Discussion: The purpose of this systematic review was to evaluate the most recent studies regarding a potential effectiveness of NMES as a treatment for oropharyngeal dysphagia considering different aspects. It could generally be concluded that there is a considerable amount of level 2 studies which suggest that NMES is an effective treatment option, especially when combined with TDT for patients with dysphagia after stroke and patients with Parkinson’s disease, or with different kinds of brain injuries. Further research is still necessary in order to clarify which stimulation protocols, parameters and therapy settings are most beneficial for certain patient groups and degrees of impairment.
Carboranyl Analogues of Mefenamic Acid and Their Biological Evaluation

Mefenamic acid represents a widely used nonsteroidal anti-inflammatory drug (NSAID) to treat the pain of postoperative surgery and heavy menstrual bleeding. Like other NSAIDs, mefenamic acid inhibits the synthesis of prostaglandins by nonselectively blocking cyclooxygenase (COX) isoforms COX-1 and COX-2. For the improved selectivity of the drug and, therefore, reduced related side effects, the carborane analogues of mefenamic acid were evaluated. The ortho-, meta-, and para-carborane derivatives were synthesized in three steps: halogenation of the respective cluster, followed by a Pd-catalyzed B–N coupling and hydrolysis of the nitrile derivatives under acidic conditions. The COX inhibitory activity and cytotoxicity for different cancer cell lines revealed that the carborane analogues have stronger antitumor potential compared to their parent organic compound.
Structure of a 14-3-3ε:FOXO3apS253 Phosphopeptide Complex Reveals 14-3-3 Isoform-Specific Binding of Forkhead Box Class O Transcription Factor (FOXO) Phosphoproteins

The transcriptional activity of Forkhead Box O3 (FOXO3a) is inactivated by AKT-mediated phosphorylation on Serine 253 (S253), which enables FOXO3a binding to 14-3-3. Phosphorylated FOXO3a binding to 14-3-3 facilitates the nuclear exclusion of FOXO3a, causing cancer cell proliferation. The FOXO3a/14-3-3 interaction has, therefore, emerged as an important therapeutic target. Here, we report a comprehensive analysis using fluorescence polarization, isothermal titration calorimetry, small-angle X-ray scattering, X-ray crystallography, and molecular dynamics simulations to gain molecular-level insights into the interaction of FOXO3apS253 phosphopeptide with 14-3-3ε. A high-resolution structure of the fluorophore-labeled FOXO3apS253:14-3-3ε complex revealed a distinct mode of interaction compared to other 14-3-3 phosphopeptide complexes. FOXO3apS253 phosphopeptide showed significant structural difference in the positions of the -3 and -4 Arg residues relative to pSer, compared to that of a similar phosphopeptide, FOXO1pS256 bound to 14-3-3σ. Moreover, molecular dynamics studies show that the significant structural changes and molecular interactions noticed in the crystal structure of FOXO3apS253:14-3-3ε are preserved over the course of the simulation. Thus, this study reveals structural differences between the binding to 14-3-3 isoforms of FOXO1pS256 versus FOXO3apS253, providing a framework for the rational design of isoform-specific FOXO/14-3-3 protein–protein interaction inhibitors for therapy.
Dual-modality fluorescence lifetime imaging-optical coherence tomography intravascular catheter system with freeform catheter optics

Abstract. Significance: Intravascular imaging is key to investigations into atherosclerotic plaque pathobiology and cardiovascular diagnostics overall. The development of multimodal imaging devices compatible with intracoronary applications has the potential to address limitations of currently available single-modality systems. Aim: We designed and characterized a robust, high performance multimodal imaging system that combines optical coherence tomography (OCT) and multispectral fluorescence lifetime imaging (FLIm) for intraluminal simultaneous assessment of structural and biochemical properties of coronary arteries. Approach: Several shortcomings of existing FLIm-OCT catheter systems are addressed by adopting key features, namely (1) a custom fiber optic rotary joint based on an air bearing, (2) a broadband catheter using a freeform reflective optics, and (3) integrated solid-state FLIm detectors. Improvements are quantified using a combination of experimental characterization and simulations. Results: Excellent UV and IR coupling efficiencies and stability (IR: 75.7 % ± 0.4 % , UV: 45.7 % ± 0.35 % ) are achieved; high FLIm optical performance is obtained (UV beam FWHM: 50 μm) contemporaneously with excellent OCT beam quality (IR beam FWHM: 17 μm). High-quality FLIm OCT image of a human coronary artery specimen was acquired. Conclusion: The ability of this intravascular imaging system to provide comprehensive structural and biochemical properties will be valuable to further our understanding of plaque pathophysiology and improve cardiovascular diagnostics.
Selección de cepas productoras de enzimas ligninolíticas nativas del Valle del Yaqui

Introduction: Lignocellulose consists of three polymers: cellulose, hemicellulose and lignin. Biopulping is a pretreatment for lignocellulose using fungi as a means for delignifying it previously to pulping, since fungi may content an enzyme complex including lignin peroxidase, laccase, manganese peroxidase. Native fungi may have the ability to delignify lignocellulosic material such as wheat straw, wood and others. Method: This work used ten strains from COLMENA collection at the Microbial Resource Biotechnology Laboratory (Instituto Tecnologico de Sonora). The selection of strains was performed by measuring the halo of enzyme activity of LiP, Lac, Xil during 14 days of incubation and determination of enzymatic index relating the area of enzymatic activity halo against the fungi growth halo, using the software Image J 1.44 for the calculation of the enzymatic potential index. Results: Ten strains were evaluated and the best strain for LiP was TSM35 with potential index of 3.83±0.29, for Lac and Xil the strain was TSO46 with potential index of 20.37±2.70 and 1.38±0.00 respectively. With this study it is possible determine the potential for incorporate native fungi in a pretreatment process for delignification (biopulping). Discussion or Conclusion: From ten strains studied, three strains had ligninolytic activity by excretion lignin peroxidase, lacase and xylanase and they have the potential to be used in pretreatments in a delignification process.
A Data-Driven Biopsychosocial Framework Determining the Spreading of Chronic Pain

Chronic pain conditions are complex syndromes characterized by a mosaic of biological, psychological, and social factors. We derived predictive models for the number of co-existing pain sites in the UK Biobank and identified a common risk score that classified different chronic pain conditions in cross-sectional data, predicted the development of chronic pain in pain-free individuals, and determined the spreading of chronic pain to multiple sites or its recovery nine years later. The features with the strongest prognosis included sleeplessness, feeling 'fed-up', tiredness, stressful life events, and a BMI > 30. The risk score for pain was associated with an inflammatory blood marker, a polygenic risk score for pain, and a neuroimaging-based marker for sustained pain. The demonstration of a common biopsychosocial risk factor for different clinical pain conditions may help better characterize a general chronic pain syndrome, tailor research protocols, optimize patient randomization in clinical trials, and improve pain management.
Morphology of proximal and distal human semitendinosus compartments and the effects of distal tendon harvesting for anterior cruciate ligament reconstruction

The human semitendinosus muscle is characterized by a tendinous inscription separating proximal and distal neuromuscular compartments. As each compartment is innervated by separate nerve branches, potential exists for independent operation and control of compartments. However, the morphology and function of each compartment have not been thoroughly examined in an adult human population. Further, the distal semitendinosus tendon is typically harvested for use in anterior cruciate ligament reconstruction surgery, which induces long‐term morphological changes to the semitendinosus muscle‐tendon unit. It remains unknown if muscle morphological alterations following anterior cruciate ligament reconstruction are uniform between proximal and distal semitendinosus compartments. Here, we performed magnetic resonance imaging on 10 individuals who had undergone anterior cruciate ligament reconstruction involving an ipsilateral distal semitendinosus tendon graft 14 ± 4 months prior, extracting morphological parameters of the whole semitendinosus muscle and each individual compartment from both the (non‐injured) contralateral and surgical legs. In the contralateral leg, volume and length of the proximal compartment were smaller than the distal compartment. No between‐compartment differences in volume or length were found for anterior cruciate ligament reconstructed legs, likely due to greater shortening of the distal compared to the proximal compartment after anterior cruciate ligament reconstruction. The maximal anatomical cross‐sectional area of both compartments was substantially smaller on the anterior cruciate ligament reconstructed leg but did not differ between compartments on either leg. The absolute and relative between‐leg differences in proximal compartment morphology on the anterior cruciate ligament reconstructed leg were strongly correlated with the corresponding between‐leg differences in distal compartment morphological parameters. Specifically, greater between‐leg morphological differences in one compartment were highly correlated with large between‐leg differences in the other compartment, and vice versa for smaller differences. These relationships indicate that despite the heterogeneity in compartment length and volume, compartment atrophy is not independent or random. Further, the tendinous inscription endpoints were generally positioned at the same proximodistal level as the compartment maximal anatomical cross‐sectional areas, providing a wide area over which the tendinous inscription could mechanically interact with compartments. Overall, results suggest the two human semitendinosus compartments are not mechanically independent.
Frequency of TERT Promoter Mutations in Real-World Analysis of 2,092 Thyroid Carcinoma Patients

Background Telomerase reverse transcriptase (TERT) promoter mutations are associated with increased recurrence and mortality in patients with thyroid carcinoma. Previous studies on TERT promoter mutations were retrospectively conducted on a limited number of patients. Methods We prospectively collected data on all consecutive patients who underwent thyroid carcinoma surgery between January 2019 and December 2020 at the Samsung Medical Center, Seoul, Korea. We included 2,092 patients with thyroid carcinoma. Results Of 2,092 patients, 72 patients (3.4%) had TERT promoter mutations. However, the frequency of TERT promoter mutations was 0.5% in papillary thyroid microcarcinoma (PTMC) ≤1 cm and it was 5.8% in papillary thyroid carcinoma (PTC) >1 cm. The frequency of TERT promoter mutations was significantly associated with older age at diagnosis (odds ratio [OR], 1.12; P<0.001), larger primary tumor size (OR, 2.02; P<0.001), and aggressive histological type (OR, 7.78 in follicular thyroid carcinoma; OR, 10.33 in poorly differentiated thyroid carcinoma; OR, 45.92 in anaplastic thyroid carcinoma; P<0.001). Advanced T stage, advanced N stage, and distant metastasis at diagnosis were highly prevalent in mutated thyroid cancers. However, initial distant metastasis was not present in patients with TERT promoter mutations in PTMC. Although the C228T mutation was more highly detected than the C250T mutation (64 cases vs. 7 cases), there were no significant clinicopathological differences. Conclusion This study is the first attempt to investigate the frequency of TERT promoter mutations in a real-world setting. The frequency of TERT promoter mutations in PTC was lower than expected, and in PTMC, young patients, and female patients, the frequency was very low.
AKR2A is involved in the flowering process of Arabidopsis thaliana

ABSTRACT Flowering at an appropriate time is crucial for plant development and reproduction. In Arabidopsis, the flowering process is managed by a regulatory network composed of at least 6 independent pathways. As a core protein in flowering regulation, FLOWERING LOCUS T (FT) participates in almost all these pathways. ANKYRIN REPEAT-CONTAINING PROTEIN 2A (AKR2A) was initially discovered as a 14-3-3-interacting protein. It was then found to be involved in the transportation of chloroplast outer membrane proteins and the resistance to low-temperature stress. Here, we identified an akr2a null mutant with a delayed flowering phenotype. Through the quantitative real-time PCR (qRT-PCR) and bimolecular fluorescence complementation (BiFC) assays, we demonstrated that AKR2A modulates the flowering process through its interaction with FT.