Miracle-dz/UniFAR-FTUs huggingface dataset:
Multicenter Study of Serous Cystic Neoplasm of the Japan Pancreas Society

Objectives There have been only a few reports on follow-up results of serous cystic neoplasm (SCN) of the pancreas. The frequency of malignancy and surgical indication of SCN are not determined yet. Methods In this multi-institutional study of the Japan Pancreas Society, a total of 172 patients with SCN were enrolled. The mean follow-up period was 4.5 years. Surgical resection was performed in 90 patients, whereas the remaining 82 were simply observed. Results Of all patients, 20% were symptomatic. The tumor was located in the pancreatic head (39%), body (35%), and tail (22%). The mean diameter of the tumor was 4.1 cm. None of the patients showed distant or lymph node metastasis except for liver metastasis found in 2 patients (1.2%). No patient died during the follow-up. The preoperative diagnosis did not correctly identify SCN in 57 (63%) of 90 resected cases. A honeycomb appearance, which is one of the most characteristic findings of SCN, could be diagnosed better by endoscopic ultrasonography than by other imaging diagnostic modalities. Conclusions Surgical resection should be considered only when clear distinction from other surgical diseases is difficult, when symptoms or mass effects are present, and when the tumor size is large.
Enhanced Control of a DFIG-Based Wind-Power Generation System With Series Grid-Side Converter Under Unbalanced Grid Voltage Conditions

This paper presents an enhanced control method for a doubly fed induction generator (DFIG)-based wind-power generation system with series grid-side converter (SGSC) under unbalanced grid voltage conditions. The behaviors of the DFIG system with SGSC during network unbalance are described. By injecting a series control voltage generated from the SGSC to balance the stator voltage, the adverse effects of voltage unbalance upon the DFIG, such as stator and rotor current unbalances, electromagnetic torque, and power pulsations, can be removed, and then the conventional vector control strategy for the rotor-side converter remains in full force under unbalanced conditions. Meanwhile, three control targets for the parallel grid-side converter (PGSC) are identified, including eliminating the oscillations in the total active power or reactive power, or eliminating negative-sequence current injected to the grid. Furthermore, a precise current reference generation strategy for the PGSC has been proposed for the PGSC to further improve the operation performance of the whole system. Finally, the proposed coordinated control strategy for the DFIG system with SGSC has been validated by the simulation results of a 2-MW-DFIG-based wind turbine with SGSC and experimental results on a laboratory-scale experimental rig under small steady-state grid voltage unbalance.
Motivational Pharmacotherapy: Combining Motivational Interviewing and Antidepressant Therapy to Improve Treatment Adherence

Treatment non-adherence in psycho-pharmacotherapy remains a significant challenge to the effective clinical management of psychiatric disorders, especially among underserved racial/ethnic groups. This article introduces motivational pharmacotherapy, an approach that integrates motivational interviewing into psycho-pharmacotherapy sessions in order to increase treatment adherence. We describe what aspects of motivational interviewing were incorporated into motivational pharmacotherapy and how we tailored the intervention to the clinical and cultural characteristics of monolingual Spanish-speaking immigrants with major depressive disorder. Transcriptions of the interactions between psychiatrists and patients help illustrate this approach. In our experience, motivational pharmacotherapy differs substantially from standard pharmacotherapy in how it recasts clinicians and patients as equal experts, prioritizes patients' motivation to engage in treatment rather than clinicians' multiple inquiries about symptoms, encourages patients' self-efficacy to overcome barriers, and attends to the momentum of patients' language about commitment to change. We also found that motivational pharmacotherapy can be feasibly incorporated into medication treatment, can be tailored to patients' culture and disorder, and may help increase adherence to psycho-pharmacotherapy.
Closed-form expression for the dynamic dispersion coefficient in Hagen-Poiseuille flow

We present an exact expression for the upscaled dynamic dispersion coefficient (D) for one-dimensional transport by Hagen-Poiseuille flow which is the basis for modeling transport in porous media idealized as capillary tubes. The theoretical model is validated by comparing the breakthrough curves (BTCs) from a 1D advection-dispersion model with dynamic D to that from direct numerical solutions utilizing a 2D advection-diffusion model. Both Taylor dispersion theory and our new theory are good predictors of D at lower Peclet Number (Pe) regime, but gradually fail to capture most parts of BTCs as Pe increases. However, our model generally predicts the mixing and spreading of solutes better than Taylor’s theory since it covers all transport regimes from molecular diffusion, through anomalous transport, and to Taylor dispersion. The model accurately predicts D based on the early part of BTCs even at relatively high Pe regime (~62) where the Taylor’s theory fails. Furthermore, the model allows for calculation of the time scale that separates Fickian from non-Fickian transport. Therefore, our model can readily be used to calculate dispersion through short tubes of arbitrary radii such as the pore throats in a pore network model.
Some products involving the fourth Greek letter family element δ̃ s in the Adams spectral sequence

Let p be an odd prime and A be the mod p Steenrod algebra. For computing the stable homotopy groups of spheres with the classical Adams spectral sequence, we must compute the E2 -term of the Adams spectral sequence, Ext A ( p, p) . In this paper we prove that in the cohomology of A , the product k0hnδ̃s+4 ∈ Ext s+7,t(s,n)+s A ( p, p) , is nontrivial for n ≥ 5, and trivial for n = 3, 4, where δ̃s+4 is actually α̃ (4) s+4 described by Wang and Zheng, p ≥ 11, 0 ≤ s < p−4 and t(s, n) = 2(p−1)[(s+2)+(s+4)p+(s+3)p+(s+4)p+p] . Key word and phrases: Steenrod algebra, cohomology, Adams spectral sequence, May spectral sequence.
Research of Targets Detection Based on Integer Wavelet Transform and Utilize in TV Tracking System

In this paper,we present a method of detecting small targets and realize algorithm in TV tracking system. The approach uses lifting wavelet transform and finds parts having the same feature in the targets. We utilize one of integer-type lifting wavelet transforms that contains rounding-off arithmetic for mapping integers to integers. The advantage of using integer-type wavelet transform is simple and robust to noise. Simulation illustrated the method can detect and track the moving targets in dim background. We would test our method in the TV tracking system.
Statistical analysis of data from limiting dilution cloning to assess monoclonality in generating manufacturing cell lines

Assurance of monoclonality of recombinant cell lines is a critical issue to gain regulatory approval in biological license application (BLA). Some of the requirements of regulatory agencies are the use of proper documentations and appropriate statistical analysis to demonstrate monoclonality. In some cases, one round may be sufficient to demonstrate monoclonality. In this article, we propose the use of confidence intervals for assessing monoclonality for limiting dilution cloning in the generation of recombinant manufacturing cell lines based on a single round. The use of confidence intervals instead of point estimates allow practitioners to account for the uncertainty present in the data when assessing whether an estimated level of monoclonality is consistent with regulatory requirements. In other cases, one round may not be sufficient and two consecutive rounds are required to assess monoclonality. When two consecutive subclonings are required, we improved the present methodology by reducing the infinite series proposed by Coller and Coller (Hybridoma 1983;2:91–96) to a simpler series. The proposed simpler series provides more accurate and reliable results. It also reduces the level of computation and can be easily implemented in any spreadsheet program like Microsoft Excel. © 2016 American Institute of Chemical Engineers Biotechnol. Prog. , 32:1061–1068, 2016
MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT

The hypoxia-inducible factor (HIF) pathway is essential for cell survival under low oxygen and plays an important role in tumor cell homeostasis. We investigated the function of miR-210, the most prominent microRNA up-regulated by hypoxia and a direct transcriptional target of HIFs. miR-210 expression was elevated in multiple cancer types and correlated with metastasis of breast and melanoma tumors. miR-210 overexpression in cancer cell lines bypassed hypoxia-induced cell-cycle arrest and partially reversed the hypoxic gene expression signature. We identified MNT, a known MYC antagonist, as a miR-210 target. MNT mRNA contains multiple miR-210 binding sites in the 3' UTR and its knockdown phenocopied miR-210 overexpression. Furthermore, loss of MYC abolished miR-210-mediated override of hypoxia-induced cell-cycle arrest. Comparison of miR-210 and MYC overexpression with MNT knockdown signatures also indicated that miR-210 triggered a "MYC-like" transcriptional response. Thus, miR-210 influences the hypoxia response in tumor cells through targeting a key transcriptional repressor of the MYC-MAX network.
A Patient with a Resistant Major Depression Disorder Treated with Deep Brain Stimulation in the Inferior Thalamic Peduncle

OBJECTIVE AND IMPORTANCE: The present report explored the effect of electrical stimulation on the inferior thalamic peduncle in a patient with resistant major depression disorder (MDD). CLINICAL PRESENTATION: This report refers to a 49-year-old woman with a history of recurrent episodes of major depression for 20 years (12 episodes and 2 hospitalizations), fulfilling Diagnostic and Statistical Manual of Mental Disorders, 4th edition, revised, criteria for MDD; in addition, the patient met criteria for borderline personality disorder and bulimia. Her longest episode of depression with suicidal ideation began 5 years before surgery. The patient’s symptom array responded poorly to different combinations of antidepressants, cognitive therapy, and electroconvulsive therapy, which induced improvement only for short periods of time. Immediately before surgery, her Global Assessment of Functioning score was 20 and her Hamilton Depression Scale score ranged from 33 to 42. The patient was proposed for surgery for MDD. INTERVENTION: The patient had bilateral eight-contact electrodes stereotactically implanted for stimulation of areas at and around the inferior thalamic peduncle. Electrode position was corroborated by unilateral electrical stimulation searching for recruiting responses and regional direct current shifts in the electroencephalogram. Recording electrodes were replaced by tetrapolar electrodes for deep brain stimulation and connected to an internalized stimulation system for continuous bipolar stimulation at 130 Hz, 0.45 milliseconds, 2.5 V. Bimonthly follow-up included psychiatric and neuropsychological evaluations performed over the course of 24 months. After 8 months of ON stimulation, the patient entered a double-blind protocol with stimulators turned OFF. Improvement of depression measured by the Hamilton Depression Scale score was evident after initial placement of electrodes without electrical stimulation. Depression relapsed partially at the end of the first week. Electrical stimulation further improved depression, normalizing depression scores and neuropsychological performance. Patient depression scores ranked between 2 and 8 during 8 months of ON stimulation without antidepressant medication. After stimulation was turned OFF, spontaneous fluctuations in patient symptoms reflected by Hamilton Depression Scale and Global Assessment of Functioning scores were documented; these fluctuations disappeared after stimulation was turned on by Month 20. CONCLUSION: Complicated patients with comorbid conditions are common referrals to psychosurgery services. In this report, we present promising results of electrical stimulation of the inferior thalamic peduncle to treat recurrent unipolar depression in a patient with MDD and borderline personality disorder who responded poorly to treatment.
Three-step needle withdrawal method: a modified technique for reducing the rate of pneumothorax after CT-guided lung biopsy.

BACKGROUND Computed tomography (CT)-guided transthoracic needle biopsy is reliable and has become popular for diagnosing pulmonary lesions. Pneumothorax is the most common complication of transthoracic needle biopsy. The aim of this study was to report our preliminary experience with a three-step needle withdrawal technique for CT-guided lung-biopsy, with emphasis on reduction of the pneumothorax rate. METHODS A total of 146 patients (85 men and 61 women; mean age, 66.1 years; age range 19-91 years) with a pulmonary lesion underwent single slice CT-guided lung biopsy. We used a 17-gauge coaxial needle for guidance and a 18- gauge cutting needle to perform the biopsy. We used a three-step method to withdraw the needle. Images were reviewed to assess the patients' posture and the size, location, and depth of the tumor. Any pneumothorax or chest tube usage was noted. RESULTS Pneumothorax occurred in 23 (15.8%) patients, two of whom underwent chest-tube insertion. All 23 patients with a lesion deeper than 4 cm deep hada pneumothorax. In all patients with pneumothorax, lesions were smaller than 2 cm. CONCLUSIONS Our modified CT-guided lung biopsy method with a three-step needle withdrawal technique appears effective with a relatively low pneumothorax rate. Predictors of pneumothorax in our study were a lesion deeper than 4 cm and a lesion smaller than 2 cm.
The triose phosphate‐3‐phosphoglycerate‐phosphate translocator from spinach chloroplasts: nucleotide sequence of a full‐length cDNA clone and import of the in vitro synthesized precursor protein into chloroplasts.

The nucleotide sequence of several cDNA clones coding for the phosphate translocator from spinach chloroplasts has been determined. The cDNA clones were selected from a lambda gt10 library prepared from poly(A)+ mRNA of spinach leaves using oligonucleotide probes modeled from amino acid sequences of tryptic peptides prepared from the isolated translocator protein. A 1439 bp insert of one of the clones codes for the entire 404 amino acid residues of the precursor protein corresponding to a mol. wt of 44,234. The full‐length clone includes 21 bp at the transcribed non‐coding 5′ region with the ribosome initiation sequence ACAATGG, a 1212 bp coding region and 199 bp at the non‐coding 3′ region excluding the poly(A) tail which starts 17 bp downstream from a putative polyadenylation signal, AATAAT. According to secondary structure predictions the mature part of the chloroplast phosphate translocator exhibits high hydrophobicity and consists of at least seven membrane‐spanning segments. Using plasmid‐programmed wheat germ lysate the precursor protein was synthesized in vitro and could be imported into spinach chloroplasts where it is inserted into the inner envelope membrane.
REGRESSION OF UVEAL MALIGNANT MELANOMAS FOLLOWING COBALT-60 PLAQUE: Correlates Between Acoustic Spectrum Analysis and Tumor Regression

Parameters derived from computer analysis of digital radio-frequency (rf) ultrasound scan data of untreated uveal malignant melanomas were examined for correlations with tumor regression following cobalt-60 plaque. Parameters included tumor height, normalized power spectrum and acoustic tissue type (ATT). Acoustic tissue type was based upon discriminant analysis of tumor power spectra, with spectra of tumors of known pathology serving as a model. Results showed ATT to be correlated with tumor regression during the first 18 months following treatment. Tumors with ATT associated with spindle cell malignant melanoma showed over twice the percentage reduction in height as those with ATT associated with mixed/epithelioid melanomas. Pre-treatment height was only weakly correlated with regression. Additionally, significant spectral changes were observed following treatment. Ultrasonic spectrum analysis thus provides a noninvasive tool for classification, prediction and monitoring of tumor response to cobalt-60 plaque.
Cardiac magnetic resonance for prognostic assessment: present applications and future directions

Cardiac magnetic resonance is increasingly used in clinical practice for both diagnostic and prognostic purposes. In the field of ischemic heart disease, perfusion imaging permits the assessment of ischemia, which is strongly related to future cardiac events and mortality. Late gadolinium enhancement is also associated with the prognosis and can be used as a marker of functional recovery. Cardiac magnetic resonance also permits the detection of microvascular obstruction and infarct hemorrhage, both related to an adverse outcome. In non-ischemic heart disease, the presence of late gadolinium enhancement is linked to mortality and hard events. Finally, coronary angiography, as well as new techniques, such as T1 mapping, may also have a prognostic role.
A Domain Independent Approach to Clinical Decision Support

Continuing our work from the inaugural running of the Clinical Decision Support track in 2014, we submitted runs to the 2015 evaluation. Our approach this year was very similar to that used in 2014 (Xu et al., 2014). Our submitted runs were created using the JHU HAIRCUT retrieval engine, and featured use of character n-gram indexing and use of pseudo-relevance feedback. The main contribution is investigating the retrieval of scientific medical documents using a domain independent approach.
Young adults' ideas of cure prior to psychoanalytic psychotherapy.

The study aims to explore systematically the ideas of cure among young adults prior to psychoanalytic psychotherapy. Forty-six individuals aged 18 to 25 years who applied for psychotherapy underwent the Private Theories Interview (PTI). Twenty distinct categories of ideas of cure were identified. Based on these categories, a theoretical model was constructed with the dimensions, Approaching-Distancing and Doing-Receiving. Individuals were classified into types using "ideal type analysis. " Seven ideal types were formed: Processing and Understanding, Mastering Through Own Will and Action, Talking, Discordant Ideas, Incoherent Ideas, Getting It Out, and Avoiding or Placing the Solution onto Others. New hypotheses emerged concerning ideas of cure as an important factor for psychotherapy matching, thus potentially predicting premature termination, alliance, and outcome.
Approches vers des modèles unifiés pour l'intégration de bases de connaissances. (Approaches Towards Unified Models for Integrating Web Knowledge Bases)

Ma these a comme but l’integration automatique de nouveaux services Web dans une base de connaissances. Pour chaque methode d’un service Web, une vue est calculee de maniere automatique. La vue est representee comme une requete sur la base de connaissances. L’algorithme que nous avons propose calcule egalement une fonction de transformation XSLT associee a la methode qui est capable de transformer les resultats d’appel dans un fragment conforme au schema de la base de connaissances. La nouveaute de notre approche c’est que l’alignement repose seulement sur l’alignement des instances. Il ne depend pas des noms des concepts ni des contraintes qui sont definis par le schema. Ceci le fait particulierement pertinent pour les services Web qui sont publies actuellement sur le Web, parce que ces services utilisent le protocole REST. Ce protocole ne permet pas la publication de schemas. En plus, JSON semble s’imposer comme le standard pour la representation des resultats d’appels de services. A difference du langage XML, JSON n’utilise pas de noeuds nommes. Donc les algorithmes d’alignement traditionnels sont prives de noms de concepts sur lesquels ils se basent.
Quelle / Publication : Ausgabe / Issue : Seite / Page : European Coatings Journal 04 / 2005 170 Nanoparticles in coatings

Tailoring properties to applications. Steffen Pilotek, Frank Tabellion. In order to fully realise the potential advantages of nanoparticles in coatings, it is necessary to consider carefully the techniques of dispersion and stabilisation used. Surface modification is essential to retain the particles in a dispersed state, and this must be tailored to the coatings formulation. The chemomechanical processing of nanoparticles in an agitator bead mill is a versatile means of producing tailored nanoparticles in a highly dispersed state. The market potential of nanoparticles is estimated by market researchers to be enormous [1], and coatings are among the first applications to be discovered by the nanoparticle industry. This is understandable in the light of the many potential advantages nanoparticles offer in coatings applications. This interest derives from the property profiles of nanoparticles. First, nanoparticles possess the intrinsic properties of the material they are made of. Silica remains silica at small scales, titanium dioxide still has a high refractive index, and zinc oxide still absorbs UV light if its particles are nano-scale. These features can be retained within a coating. Probably the most notable property as the particle size is reduced is the change in light scattering: particles which are small enough may produce transparent coatings. This situation is not simple, however. Nanoparticles do not induce transparency directly, but rather their light-scattering effects decrease with decreasing particle size. At the same time, light scattering is dependent on the difference in refractive index between particle and surrounding medium. A close match in refractive indices favours the creation of transparent mixtures.
Molecular cloning of Escherichia coli K-12 hexuronate system genes: exu region

Lambda transducing bacteriophages carrying the exu region (min 66) of Escherichia coli K-12 (lambda pexu) were previously isolated. A restriction map of these phages is presented. Starting from the lambda pexu phage deoxyribonucleic acid, various endonuclease-generated exu fragments were subcloned into multicopy plasmid vectors, using in vitro recombination techniques. The precise location of the exu genes, relative to the endonuclease sites, was determined. Plasmids carrying uxaC and uxaA genes overproduced the corresponding enzymes 30- to 40-fold. When these plasmids were expressed in an in vitro protein-synthesizing system, two polypeptides of 50,500 and 53,000 molecular weights appeared and were identified as the uxaC and uxaA gene products. A 2.6-kilobase-pair deoxyribonucleic acid fragment was shown to code for a functional exuR repressor which controls the expression of the exu region. Plasmids containing this fragment overproduced the regulatory protein. It was possible to localize the operator region, uxaCo, which overlapped a PstI endonuclease site, and to confirm the transcriptional direction of the uxaC-uxaA operon from uxaC to uxaA.