Miracle-dz/UniFAR-FTUs huggingface dataset:
Impaired production priming and intact identification priming in Alzheimer's disease

This study examined the distinction between identification and production processes in repetition priming for 16 patients with Alzheimer's disease (AD) and 16 healthy old control participants (NC). Words were read in three study phases. In three test phases, participants (1) reread studied words, along with unstudied words, in a word-naming task (identification priming); (2) completed 3-letter stems of studied and unstudied words into words in a word-stem completion task (production priming); and (3) answered yes or no to having read studied and unstudied words in a recognition task (explicit memory). Explicit memory and word-stem completion priming were impaired in the AD group compared to the NC group. After correcting for baseline slowing, word-naming priming magnitude did not differ between the groups. The results suggest that the distinction between production and identification processes has promise for explaining the pattern of preservation and failure of repetition priming in AD. (JINS, 2001, 7, 785–794.)
DISLOCATION MECHANICS BASED ANALYSIS OF MATERIAL DYNAMICS BEHAVIOR

Mesures de l'influence de la taille des grains sur la contrainte de maclage du fer Armco et d'un acier au carbone. Calcul des deformations par maclage a partir d'un modele constitutif base sur les mecanismes de dislocations en tenant compte des effets de frottement visqueux et de la taille des grains. Comparaison avec des resultats experimentaux pour le fer cubique centre et pour le cuivre cubique a face centree
Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

Calorie restriction increases life span in many organisms, including the budding yeast Saccharomyces cerevisiae. From a large-scale analysis of 564 single-gene–deletion strains of yeast, we identified 10 gene deletions that increase replicative life span. Six of these correspond to genes encoding components of the nutrient-responsive TOR and Sch9 pathways. Calorie restriction of tor1D or sch9D cells failed to further increase life span and, like calorie restriction, deletion of either SCH9 or TOR1 increased life span independent of the Sir2 histone deacetylase. We propose that the TOR and Sch9 kinases define a primary conduit through which excess nutrient intake limits longevity in yeast.
Pure alpha-secreting pituitary adenomas.

Isolated hypersecretion of the alpha subunit of the glycoprotein hormones occurred in two men with previously diagnosed "nonfunctioning chromophobe adenomas. " The alpha hypersecretion was unresponsive to hypothalamic releasing hormone, thyroid hormone, and sex-steroid hormones. After trans-sphenoidal surgery and conventional pituitary irradiation, alpha secretion was decreased. Increased quantities of immunologically active and biologically inactive luteinizing hormone (LH) material were detected in serum and in tumor homogenate. Immunologic and gel-chromatographic studies determined that only the alpha subunit was present and that it was cross-reacting in the LH immunoassay. These studies suggest that the alpha subunit may be a useful marker of pituitary tumors, particularly in patients without clinical evidence of hormonal hypersecretion.
Evaluation of maxillary central incisors on the noncleft and cleft sides in patients with unilateral cleft lip and palate-Part 1: Relationship between root length and orthodontic tooth movement.

OBJECTIVES To measure the root lengths of maxillary central incisors (U1) and evaluate the relationship among U1 root length, tooth movement, and type of treatment appliance in patients with unilateral cleft lip and palate over a long-term follow-up period. MATERIALS AND METHODS Occlusal radiographs of 30 patients with unilateral cleft lip and palate, acquired less than 6 months before secondary alveolar bone grafting (SBG, T1) and after edgewise treatment (T2), were measured for U1 root length (R1 and R2, root lengths at T1 and T2, respectively). Frontal and lateral cephalometric radiographs acquired at eruption of U1 (T0), T1, and T2 were evaluated to determine the inclination and position of U1. RESULTS The average values of R1 and R2 on the cleft side were significantly lower than those on the noncleft side. Frontal cephalometric analysis revealed that the horizontal distance of the root apex from the median vertical line at T0 on the cleft side was significantly smaller than that on the noncleft side and was correlated with short U1 root length on the cleft side. On the other hand, R1 in patients treated with maxillary protraction appliances between T0 and T1 was significantly shorter than that in patients without maxillary protraction appliances. However, none of the changes in cephalometric measurements were correlated with root length. CONCLUSIONS In patients with unilateral cleft lip and palate, the short root length of cleft-adjacent central incisors might be associated with the horizontal position of the root apex. In addition, orthodontic treatment with a maxillary protraction appliance before secondary alveolar bone grafting might be associated with short U1 root length.
X‐ray observations and the search for Fermi ‐LAT γ‐ray pulsars

The Large Area Telescope (LAT) on Fermi has detected ∼150 γ-ray pulsars, about a third of which were discovered in blind searches of the γ-ray data. Because the angular resolution of the LAT is relatively poor and blind searches for pulsars (especially millisecond pulsars, MSPs) are very sensitive to an error in the position, one must typically scan large numbers of locations. Identifying plausible X-ray counterparts of a putative pulsar drastically reduces the number of trials, thus improving the sensitivity of pulsar blind searches with the LAT. I discuss our ongoing program of Swift, XMM-Newton, and Chandra observations of LAT unassociated sources in the context of our blind searches for γ-ray pulsars. (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
The Impact of Anesthesia on Glycine Absorption in Operative Hysteroscopy: A Randomized Controlled Trial

BACKGROUND:Operative hysteroscopy requires the use of a distension medium and its absorption can lead to serious consequences from intravascular volume overload and water intoxication. We compared the impact of 2 types of anesthesia (general anesthesia and local anesthesia with sedation) on the absorption of glycine solution in operative hysteroscopy. METHODS:A randomized controlled trial was conducted over a 17-month period. Eligible patients undergoing operative hysteroscopy for abnormal uterine bleeding were randomized in 2 groups: a general anesthesia group and a local anesthesia with sedation group. The primary outcome was the median absorption of the glycine solution (10th–90th percentile) measured with an automated tandem canister system. Secondary outcomes included incidence of absorption >1000 mL, discontinued surgery because of excessive absorption, median change in serum sodium, postoperative hyponatremia, and patients' postoperative quality of life at 24 hours (8-item Short Form Health Survey questionnaire). Nonparametric analyses (Mann-Whitney U test, &khgr;2 test, and Fisher exact test) were used. RESULTS:Of 142 eligible patients, 95 agreed to participate and were randomized. Women who underwent general anesthesia had a higher median absorption of the glycine solution (10th–90th percentile) compared with women who underwent local anesthesia with sedation (480 mL [76–1300 mL] vs 253 mL [70–728 mL]; P = 0.005). General anesthesia was also associated with a higher rate of glycine solution absorption (>1000 mL [20% vs 4%; P = 0.009]) and a more rapid rate of decrease in serum sodium (≥10 mEq/L [8% vs 0%; P = 0.005]) than local anesthesia with sedation. Postoperative quality of life measures as rated by the patients were comparable between the 2 groups. CONCLUSION:Compared with general anesthesia, local anesthesia with sedation is associated with less glycine absorption and should be considered the preferred method of anesthesia for operative hysteroscopy.
Psychrobacter sanguinis: an Unusual Bacterium for Nosocomial Meningitis

ABSTRACT We report the first case of postneurosurgical meningitis due to Psychrobacter sanguinis, identified only by 16S rRNA analysis. Psychrobacter spp. usually live in deep sea environments and cold habitats. Despite a strict questioning of the patient and the medical staff, we did not find the source of this bacterium.
Severe Persistent Case of Contagious Ecthyma (Orf) in Goats

| Contagious ecthyma is an acute, highly contagious, zoonotic, debilitating and economically important viral non-systematic eruptive skin disease of small ruminants worldwide. In this report, a severe persistent case of caprine contagious ecthyma in Malaysian goats is described. Two cases of contagious ecthyma were reported to University Veterinary Hospital from a goat farm at Taman Partanian University (TPU) of UPM, Malaysia. Physical examination of the first goat revealed the presence of scabby lesions on the mouth, mucous membrane of the lips and gums, and the ventral part of the body and interdigital region. Auscultation revealed a significant crackling sounds suggestive of pneumonia. The second case was found to have lesions on its udder. The condition of both cases was clinically diagnosed as contagious ecthyma. Both cases were treated symptomatically with Flunixin Meglumine® and Norodine® 24. Infection persisted in one goat more than three months after the treatment, and it was suspected to play an important role in disease maintenance and spreading in the goat flock. Culling of persistently infected goats in this case demonstrated to be helpful in limiting the occurrence and spread of the infection in the flock.
Drug repositioning for prostate cancer: using a data-driven approach to gain new insights

Prostate cancer (PC) is the most common cancer and the third leading cause of cancer death in men worldwide. Despite its high incidence and mortality, the likelihood of a cure is low for late-stages of PC. There is an unmet need for more effective agents for treating PC. Here, we present a drug repositioning system, GenoPredict, for finding innovative drug candidates for treating PC. GenoPredict leverages upon a large amount of disease genomics data and a large-scale drug treatment knowledge base (TreatKB) that we recently constructed. We first constructed a genetic disease network (GDN) that comprised of 882 nodes and 200,758 edges and applied a network-based ranking algorithm to find diseases from GDN that are genetically related to PC. We developed a drug prioritization algorithm to reposition drugs from PC-related diseases to treat PC. When evaluated in a de-novo prediction setting using 27 FDA- approved PC drugs, GenoPredict found 25 of 27 FDA-approved PC drugs and ranked them highly (recall: 0.925, mean ranking: 27.3%, median ranking: 15.6%). When compared to PREDICT, a comprehensive drug repositioning system, in novel predictions, GenoPredict performed better than PREDICT across two evaluation datasets. GenoPredict achieved a mean average precision (MAP) of 0.447 when evaluated with 172 PC drugs extracted from 172,888 clinical trial reports, representing a 164.5% improvement as compared to a MAP of 0.169 for PREDICT. When evaluated with 72 PC drugs extracted from 43,811 ongoing clinical trial reports, GenoPredict achieved a MAP of 0.278, representing a 231.1% improvement as compared to a MAP of 0.084 for PREDICT. The data is publicly available at: http://nlp. CASE edu/public/data/PC_GenoPredict and http: //nlp. CASE edu/public/data/treatKB.
Impaired bone health in anorexia nervosa

Anorexia nervosa (AN), a condition of malnutrition, has a multitude of effects, including low bone mineral density (BMD). Much has been discovered over the last couple of decades regarding the extent and pathophysiology of low BMD in AN, including the role of gonadal steroids, neuroendocrine hormones and appetite-regulating peptides. The effects of AN on bone are particularly concerning in adolescents, who are in the process of accruing peak bone mass, and decreased rates of bone-mass accrual in these critical years are predictive of poor bone health in later life. Although dual-energy x-ray absorptiometry continues to be the standard technique for monitoring BMD, newer techniques such as quantitative computed tomography and calcaneal ultrasound are being explored. Weight and menses recovery continue to be the most effective treatment for improving BMD in AN. Further research is needed to translate the pathophysiology being unraveled into clinical applications for improving BMD in AN.
Self-Tuning PID Controller Based on Quantum Swarm Evolution Algorithm

PID control schemes have been widely used in most of control system for a long time. However, it is still a very important problem how to determine or tune the PID parameters, because these parameters have a great influence on the stability and the performance of the control system. On the other hand, in the last ten years, quantum computing is attracted as one method which gives us suitable answers for optimization problems. This paper proposes a novel quantum swarm evolution algorithm, called a quantum-inspired swarm evolution algorithm (QSEA), which is based on the concept and principles of quantum computing. The proposed algorithm adopts quantum angle to express Q-bit and improved particle swarm optimization to update automatically. After the quantum-inspired swarm evolution algorithm is described, the experiment result on the parameters of PID controller is given to show its efficiency.
Tumor size measurement and feature point extraction using an endoscope

Recently, a development of the medical instrument using the vision information is brisk. Especially, extracting the 3-dimension information from 2-dimension image is the one of the major research topics. This paper proposes the method to measure tumor size by the 3-dimension information extraction, the triangulation using the extracted 3-dimension information and the camera geometry. To extract the 3-dimension information, the Hough circle transform and triangulation are used. The Hough circle transform is used to extract a feature point from tumor models for the 3-dimension information recovery. An extracted feature point is used for recovering the depth information from the 2-dimension tumor stereo images. A tumor size measurement is done by triangulation using the depth information and camera internal parameters. Matlab and Visual C++ are used for simulation.
Effect of Long Tail and Trust on Customer Motivation behind Online Shopping Use: Comparative study between physical product and service product

This research aims at understanding the effect of long tail and trust on the customer motivation behind online shopping use. For this research, existing latest research framework Extended Unified Theory of Acceptance and Use of Technology2 (UTAUT2) is used for the basic 7 constructs of the UTAUT2 framework but two additional constructs “long tail effect” and “trust” are tested to understand whether these also influence the customer motivation to choose online channels for shopping. Research was conducted in Japan for two product categories i.e. airline ticket and book. One is a physical product while other is a service product. Both “long tail effect” and “trust” were found to have significant relationship with the intention to use, however there were some differences between the two products due to their inherent product characteristics. Inclusion of both “long tail effect” and “trust” constructs to the existing research framework is proposed in this research. this and direct of facilitating hedonic and long tail effect have positive regression but were not the significant predictors to
Clinical outcome of coronary stenting after thoracic radiotherapy: a case-control study

Objective Patients with lymphoma, lung or breast neoplasia show significant improvement in their disease-specific survival after radiotherapy (RT), but these benefits may be offset by delayed effects of irradiation of the heart. We compared clinical outcome after coronary stenting in patients with neoplastic disease and previous thoracic RT with matched patients without previous RT. Design Single-centre retrospective case-control study. Patients and methods Each patient with former thoracic RT undergoing coronary stenting between June 1998 and June 2005 was matched to two control patients according to several known prognostic factors (gender, age, available follow-up, stented vessel, drug-eluting stent use, unstable coronary disease, renal insufficiency, diabetes, bifurcational disease, stent length and size and ejection fraction). Main outcome measures Major adverse cardiac events (MACE) were defined as the composite of cardiac death, acute myocardial infarction (AMI) and target lesion revascularisation (TLR) and were assessed at latest follow-up and compared using Cox regression analyses. Results 41 patients underwent coronary stenting at 6±4 years after RT. Clinical outcome at 5±2 years after stenting was compared with outcome in 82 matched patients. For all-cause mortality, the hazard ratio for RT versus no RT was 4.2 (95% CI 1.8 to 9.5; p=0.0006). For cardiac mortality, the estimated hazard ratio was 4.2 (95% CI 1.0 to 17.0; p=0.0451). No significant differences were detected in terms of AMI, TLR, MACE or stent thrombosis. Conclusions Our findings suggest an increased risk of all-cause and cardiac mortality in patients who underwent coronary stent implantation after previous thoracic RT. Verification in larger patient populations is warranted.
A novel type 3 secretion system effector, YspI of Yersinia enterocolitica, induces cell paralysis by reducing total focal adhesion kinase

Some of the world's most important diseases are caused by bacterial pathogens that deliver toxic effector proteins directly into eukaryotic cells using type III secretion systems. The myriad of pathological outcomes caused by these pathogens is determined, in part, by the manipulation of host cell physiology due to the specific activities of individual effectors among the unique suite each pathogen employs. YspI was found to be an effector, delivered by Yersinia enterocolitica Biovar 1B, that inhibits host cell motility. The action of YspI comes about through its specific interaction with focal adhesion kinase, FAK, which is a fulcrum of focal adhesion complexes for controlling cellular motility. The interaction was defined by a specific domain of YspI that bound to the FAK kinase domain. Further examination revealed that YspI–FAK interaction leads to a reduction of FAK steady‐state levels without altering its phosphorylation state. This collection of observations and results showed YspI displays unique functionality by targeting the key regulator of focal adhesion complexes to inhibit cellular movement.
Stretch-activated channels in heart cells: relevance to cardiac hypertrophy.

Stretch-activated channels have been proposed as the transduction mechanism between load and protein synthesis in cardiac hypertrophy. Under this hypothesis, cardiac deformation is linked to an increased sodium (Na) influx, which, in turn, increases protein synthesis. We have tested whether stretch actually increases Na influx by applying patch-clamp techniques to cultured chick embryo cardiac myocytes and to freshly isolated adult guinea pig cardiomyocytes. Our experiments, in excised and cell-attached patches, revealed the existence of ionic channels that opened, or increased their frequency of opening, upon the application of negative pressures to the lumen of the patch-clamp pipettes. These stretch-sensitive channels allowed the passage of the major monovalent physiological cations, Na and potassium (K), and, to a much lesser extent, the major divalent cations calcium (Ca) and magnesium (Mg). Under normal conditions, the channels had a high open channel noise that prevented the customary, straightforward statistical analysis of single channel data. However, when one of the major monovalent cations was iso-osmotically replaced by sucrose, the open channel noise decreased significantly and permitted a good delineation of the open and closed channel states and, therefore, application of standard patch-clamp, statistical analysis techniques. Under these "sucrose," "monoionic" conditions, the reversal potential was, as one should expect, close to the equilibrium potential for the major monovalent cation present. When high extracellular K solution was used to minimize the cell resting potential, the reversal potential for these stretch-activated currents was estimated to be around -40 mV. Therefore, under normal conditions, stretch should induce an inward, depolarizing current, carried mostly by Na ions. (ABSTRACT TRUNCATED AT 250 WORDS)
EXERCISE‐LOADED BLOOD PRESSURE AND Li‐Na COUNTERTRANSPORT SYSTEM IN THE ERYTHROCYTE MEMBRANE AS PREDICTORS OF MILD ESSENTIAL HYPERTENSION PROGNOSIS

1. The blood pressure response to exercise loading, Na concentration in the erythrocyte and Li–Na countertransport (Li–Na CT) system in the erythrocyte membrane in 40 male volunteers and 98 patients with mild essential hypertension were investigated. Subjects were divided into a juvenile group (<36 years) and a middle‐aged (>36 years and <65 years) group. Exercise‐loaded blood pressure in patients with mild essential hypertension was followed up for more than 5 years.
Efficient Dynamic Lookup For Bursty Access Patterns

Internet (IP) packet forwarding is typically done by finding the longest prefix in a router table that matches the packet's destination address. Although significant effort has been devoted to the development of data structures for static and dynamic router-tables for random packet-access-patterns, considerably less effort has been expended in the development of such structures for bursty access-patterns (i.e., streams of packets in which destination addresses repeat frequently within localized windows of packets). In this paper, we first formulate a variant, ACRBT (alternative collection of red-black trees), of the CRBT (collection of red-black trees) data structure proposed earlier for dynamic router-tables. By replacing the red-black trees used in the ACRBT with splay trees, we obtain the CST (collection of splay trees) structure in which search, insert, and delete take O(log n) amortized time per operation, where n is the number of prefixes in the router table. By replacing the front end of the CST with biased skip lists, we obtain the BSLPT (biased skip lists with prefix trees) structure in which search, insert, and delete take O(log n) expected time. The CST and BSLPT structures are designed so as to perform much better when the access pattern is bursty than when it is not. Experimental results using real IPv4 routing databases and synthetically generated search sequences as well as trace sequences are presented. For extremely bursty access patterns, the CST structure is best. Otherwise, the ACRBT is recommended. Our experiments also indicate that a supernode implementation of the ACRBT usually has better search performance than does the traditional one-element-per-node implementation.