Miracle-dz/UniFAR-FTUs huggingface dataset:
Markedly prolonged paralysis after mivacurium in a patient apparently heterozygous for the atypical and usual pseudocholinesterase alleles by conventional biochemical testing.

M ivacurium is a short-duration, nondepolarizing neuromuscular blocker which is rapidly hydrolyzed by pseudocholinesterase (i.e., plasma cholinesterase, butyrlcholinesterase). Its duration of action is such that 30 minutes after an intravenous (IV) intubating dose (0.2 mg/kg), reversal is usually not necessary (1,2). Although controversial (3), this makes the drug particularly suitable for the ambulatory setting since the acetylcholinesterase inhibitors have been implicated by some in contributing to postoperative nausea and vomiting (4,5). There may also be differences with respect to nausea and vomiting between various acetylcholinesterase inhibitors (6). While the duration of action of drugs such as succinylcholine and mivacurium is short in the general population, individuals expressing variants of the pseudocholinesterase gene have prolonged durations of action (7). In those individuals, phenotypically heterozygous for the atypical (A) and usual (U) pseudocholinesterase gene (UA), mivacurium will have only a slightly prolonged duration of action (7). We describe a case in which a single dose of mivacurium resulted in 6.25 hours of paralysis in an individual apparently heterozygous (UA) based on conventional biochemical measurement (pseudocholinesterase activity and dibucaine number [DNI).
Lessons Learned About Motivation From a Pilot Physical Activity Intervention for African American Men

African American men are less likely than White men to meet physical activity recommendations, and few physical activity interventions have focused on the unique needs of African American men. Because health is not more important to men than fulfilling the role of a provider or other socially important roles, one of the biggest challenges in creating interventions for African American men is helping them identify reasons that they should prioritize both health and life goals. In a recent pilot physical activity intervention for 30- to 70-year-old African American men, we used self-determination theory and motivational interviewing principles to create worksheets that helped men identify their core values and life goals and asked them to describe how their values and goals were related to health and physical activity. We used basic statistics and thematic analysis to identify and examine key sources of motivation for men to be healthier and more physically active. We found that being healthy, a good Christian, a good spouse/partner, disciplined, and successful were among men’s most important life goals. This article highlights a strategy for identifying key sources of motivation in African American men’s lives and key themes that can be used in to enhance future interventions.
Stereo Matching with Reliable Disparity Propagation

In this paper, we propose a novel propagation-based stereo matching algorithm. Starting from an initial disparity map, our algorithm selects highly reliable pixels and propagates their disparities along the scan line to produce dense disparity results. The key idea is to construct a line segment region for each pixel with local color and connectivity constraints. The pixel wise line segments are efficiently used to compute initial disparities, select reliable pixels and determine proper propagation regions. Streaking artifacts are effectively removed in a refinement process. Experimental results demonstrate the performance of the proposed method: it ranks 5th in the Middlebury benchmark, and the results can be computed within a few seconds.
Effects of an offshore wind farm on temporal and spatial patterns in the demersal fish community

The rapid increase in offshore wind energy worldwide has raised concern about its potential risks to marine biodiversity due to habitat alteration, disturbance from noise and electro- magnetic fields. This study presents results of surveillance studies performed at the Lillgrund wind farm in Sweden to investigate the integrated effects of these factors on the abundance and distribution patterns of benthic fish communities. The studies revealed no large-scale effects on fish diversity and abundance after establishment of the wind farm when compared to the devel- opment in 2 reference areas. Changes in some species and in community composition were observed over time but occurred in parallel in at least one reference area, indicating that fish com- munities in the wind farm area were mainly driven by the same environmental factors as those in surrounding areas. However, changes at smaller spatial scales were evident. Increased densities of all studied piscivores (cod, eel, shorthorn sculpin), as well as the reef-associated goldsinny wrasse, were observed close to the foundations in the first years of operation. The increase was probably attributed mainly to local changes in distribution rather than to immigration or increased local productivity. Simultaneously, weak or no aggregation of black goby, eelpout and shore crab, all potentially reef-associated but also prey species of the studied piscivores, was observed, which may indicate enhanced top-down control near the foundations.
Management of pulmonary disease in patients with cystic fibrosis.

Cystic fibrosis is the most common life-shortening autosomal recessive disorder in the white population, affecting approximately 30,000 persons in the United States.1 It is caused by mutations in a single gene on the long arm of chromosome 7 that encodes the cystic fibrosis transmembrane conductance regulator (CFTR) (Figure 1). 2 CFTR has multiple functions involving fluid balance across epithelial cells. It acts as a chloride channel activated by cyclic adenosine monophosphate (cAMP)3 and may stimulate other chloride channels4 and inhibit sodium absorption by epithelial sodium channels.5 Mutations in the CFTR gene result in defective chloride transport in the epithelial cells in .
Beliefs About Medicines and Adherence Among Swedish Migraineurs

Background: The problem of low adherence to drug therapy is as prevalent in migraine as in any other disorder, with important consequences for the patient, such as impaired quality of life and absence from work. Beliefs about medicines have been identified as one of the most significant factors for adherence. Objective: To analyze whether beliefs about medicines and medication-related factors are associated with adherence to prophylactic drug therapy among migraineurs at a Swedish tertiary care clinic. Methods: A questionnaire was distributed to migraineurs visiting a tertiary care clinic in Sweden. All participants had recently been prescribed prophylactic medicine. The questionnaire was comprised of background questions, questions about disease characteristics, perceived effects, and adverse effects of migraine medications used, the Beliefs about Medicines questionnaire, and the Medication Adherence Report Scale. Medication-related variables, collected from patients’ records with consent, were also included. Logistic regression analysis was performed to analyze the association between beliefs about medicines, medication-related variables, and adherence to prophylactic drugs. Results: Of the 174 participants in the study, 64% were considered to be adherent to their prescribed prophylactic medicine. Users of β-blockers were significantly more adherent compared with patients using other drugs (eg, tricyclic antidepressants [TCAs) or antiepileptics); the reverse was true for patients taking TCAs. Respondents with the lowest level of education (≤9 y) expressed less concern about drugs and had a higher necessity-concerns differential compared with respondents with a higher educational level. In the final regression model, no variable was significantly associated with adherence. Conclusions: About one-third of the migraineurs did not adhere to their prophylactic drugs. Beliefs about medicines and medication-related factors could not predict nonadherence. We recommend further research on medication-related variables in relation to adherence among migraineurs.
Microtubule Organization and Function in Epithelial Cells

Microtubules are essential for many aspects of polarity in multicellular organisms, ranging from the asymmetric distribution of cell‐fate determinants in the one‐cell embryo to the transient polarity generated in migrating fibroblasts. Epithelial cells exhibit permanent cell polarity characterized by apical and basolateral surface domains of distinct protein and lipid composition that are segregated by tight junctions. They are also endowed with a microtubule network that reflects the asymmetry of their cell surface: microtubule minus‐ends face the apical‐ and microtubule plus‐ends the basal domain. Strikingly, the formation of distinct surface domains during epithelial differentiation is accompanied by the re‐organization of microtubules from a uniform array focused at the centrosome to the noncentrosomal network that aligns along the apico‐basolateral polarity axis. The significance of this coincidence for epithelial morphogenesis and the signaling mechanisms that drive microtubule repolymerization in developing epithelia remain major unresolved questions that we are only beginning to address. Studies in cultured polarized epithelial cells have established that microtubules serve as tracks that facilitate targeted vesicular transport. Novel findings suggest, moreover, that microtubule‐based transport promotes protein sorting, and even the generation of transport carriers in the endo‐ and exocytic pathways.
C Consiglio Nazionale delle Ricerche K-BOOST : A SCALABLE ALGORITHM FOR HIGH-QUALITY CLUSTERING OF MICROARRAY GENE EXPRESSION DATA

Motivation: Microarray technology for profiling gene expression levels is a popular tool in modern biological research. Applications range from tissue classification to the detection of metabolic networks, from drug discovery to time-critical personalized medicine. Given the increase in size and complexity of the data sets produced, their analysis is becoming problematic in terms of time/quality tradeoffs. Clustering genes with similar expression profiles is a key initial step for subsequent manipulations and the increasing volumes of data to be analyzed requires methods that are at the same time efficient (completing an analysis in minutes rather than hours) and effective (identifying significant clusters with high biological correlations). Results: In this paper we propose K-Boost, a novel clustering algorithm based on a combination of the Furthest-Point-First (FPF) heuristic for solving the metric k-centers problem, a stability-based method for determining the number of clusters (i.e. the value of k), and a k-means-like cluster refinement. K-Boost is able to detect the optimal number of clusters to produce. It is scalable to large data-sets without sacrificing output quality as measured by several internal and
Oral Transmission of Chronic Wasting Disease in Captive Shira's Moose

Three captive Shira's moose (Alces alces shirasi) were orally inoculated with a single dose (5 g) of whole-brain homogenate prepared from chronic wasting disease (CWD)–affected mule deer (Odocoileus hemionus). All moose died of causes thought to be other than CWD. Histologic examination of one female moose dying 465 days postinoculation revealed spongiform change in the neuropil, typical of transmissible spongiform encephalopathy. Immunohistochemistry staining for the proteinase-resistant isoform of the prion protein was observed in multiple lymphoid and nervous tissues. Western blot and enzyme-linked immunosorbent assays provided additional confirmation of CWD. These results represent the first report of experimental CWD in moose.
The type locality of Scinax dolloi (Werner, 1903) (Anura, Hylidae).

Hyla dolloi was described by Werner (1903) based on two female specimens housed at the Institut Royal des Sciences Naturelles in Brussels, Belgium (IRSNB 6481). The locality of these syntypes was referred as Brasilien (leider nicht genauer bekannt) , in free translation, Brazil (unfortunately nothing more precise is known). Since then, the type locality of the species was generically cited as in the original description ( e.g. , Nieden 1923; Harding 1983), as “Brasil” ( e.g. , Bokermann 1966; Duellman, 1977; Frost 1985), or “Brazil” ( e.g. , Lutz 1973). Moreover, besides treated as a “Doubtful species” by Lutz (1973), Hyla dolloi was considered a “name not associated with any known species” in a note by W.E. Duellman presented in Frost (1985). The combination Scinax dolloi (Werner, 1903) was established by Faivovich et al. (2005) and the species was included in the Scinax ruber clade, among the species not assigned to a species group, although considering that Scinax dolloi , S. hayii , and S. perereca form a morphologically similar group of species.
Oncoprotein from HPV 16 Enhances the Canonical Wnt / β-catenin Pathway in 1 Skin Epidermis in vivo 2

Correspondence: Dr. Patricio Gariglio. Laboratorio de Oncología Molecular, Depto. de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. Instituto Politécnico Nacional 2508, San Pedro Zacatenco, Gustavo A. Madero, 07360 México D.F. México. Phone number: 52-(55)-5747-3337, e-mail: vidal@cinvestav.mx. , Fax number: 52-(55)-5747-3931. The E6 Oncoprotein from HPV16 Enhances the Canonical Wnt/β-catenin Pathway in 1 Skin Epidermis in vivo 2 José Bonilla-Delgado, Gülay Bulut, Xuefeng Liu, Enoc M. Cortés-Malagón, Richard 3 Schlegel, Catalina Flores-Maldonado, Rubén G. Contreras, Sang-Hyuk Chung, Paul F. 4 Lambert, Aykut Üren and Patricio Gariglio 5 Centro de Investigación y de Estudios Avanzados (Cinvestav), Department of Genetics and Molecular 6 Biology, Department of Physiology Biophysics and Neurosciences. Mexico City 07360, Mexico. 7 Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Department of 8 Oncology, Department of Pathology, Washington, District of Columbia 20057,USA. 9 University of Wisconsin, School of Medicine and Public Health, McArdle Laboratory for Cancer Research, 10 Madison, Wisconsin 53706, USA. 11 Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of 12 Houston, Houston, TX 77204, USA. 13 Current Address: Hospital Juárez de México, Research Unit, Laboratory of Genetics and Molecular 14 Diagnosis, Mexico City 07760, Mexico. 15 Corresponding Author 16 JBD: jbonilla@cinvestav.mx RGC: rcontrer@fisio.cinvestav.mx 17 GB: gb243@georgetown.edu SC: schung2@central.uh. edu 18 XL: xl24@georgetown.edu PFL: plambert@wisc.edu 19 EMCM: cormalagon@yahoo.com. mx AÜ: au26@georgetown.edu 20 RS: schleger@georgetown.edu PG: vidal@cinvestav.mx 21 CFM: ceflores@fisio.cinvestav.mx 22 Running Title: HPV16-E6 enhances Canonical Wnt Signaling 23
Evaluating the indistinguishability of the XTS mode in the proposed security model

In this paper, we consider the indistinguishability of XTS in some security models for both full final block and partial final block cases. Firstly, some evaluations of the indistinguishability up-to-block are presented. Then, we present a new security model in which the adversary can not control sector number, based on an -collision resistant function. In this model, we give a bound of the distinguishing advantage that the adversary can get when attacks on XTS. The received results is an extension of [6].
Patient Preference for Transradial Access over Transfemoral Access for Cerebrovascular Procedures.

PURPOSE Shared decision-making, when physicians and patients collaborate and agree on health care decisions, is a key tenant of patient-centered care. Choice of access site for neurovascular procedures is rarely a shared decision point between physicians and patients. We present our initial evaluation of patient preference for radial over femoral access for cerebrovascular procedures. MATERIALS AND METHODS IRB approved single-center, prospective, and consecutive survey of all patients undergoing transradial access for cerebrovascular imaging and intervention. Primary inclusion criteria were patients who had previously undergone a transfemoral access procedure and chose to have their second procedure via a transradial approach. All patients underwent pre-procedural neurologic and extremity exams (including Barbeau tests for radial access suitability prior to radial access), post-procedural neurological evaluation and radial access assessment post-procedure, and complete neurological and radial access-site evaluation in the neurointerventional outpatient clinic 1-2 week post-procedure. RESULTS Twenty five consecutive patients who underwent radial access cerebrovascular procedures after previous femoral access cerebrovascular procedures (16 diagnostic angiograms and 9 interventional procedures) were included. No major complications (including hematomas, infection, or delayed radial artery occlusion) were encountered during the immediate post-procedurral period or on outpatient follow-up (average 8 days). On immediate post-procedural examination, 16% had mild bruising and 24% had mild pain at the radial access site. Of the 25 patients included in this study, 24 strongly preferred radial access over femoral access and reported that, if they needed another procedure, they would prefer radial access. CONCLUSION There was nearly unanimous patient preference for radial over femoral access for cerebrovascular procedures in this single-center prospective analysis. There were no major complications and no incidences of delayed radial occlusion. In the current age of value-based and patient-centered medicine, the radial approach should be considered for nearly all neurovascular procedures.
Prognostic impact of tissue inhibitor of matrix metalloproteinase-1 in plasma of patients with colorectal cancer.

BACKGROUND Tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in plasma has been reported to be related to disease progression in patients with colorectal cancer. However, the prognostic significance of plasma TIMP-1 has not been clarified. PATIENTS AND METHODS Concentrations of TIMP-1 protein were measured by enzyme-linked immunosorbent assay in plasma samples of 87 preoperative patients who subsequently underwent resection, and prognosis was compared. The cut-off value of plasma TIMP-1 was defined as 170 ng/ml. RESULTS When clinicopathological factors between patients with positive and those with negative plasma TIMP-1 were analyzed, significant differences were observed in lymph node metastasis, serosal invasion, curability and Dukes' classification. Univariate analysis of these factors demonstrated that depth of invasion, metastases to lymph nodes, peritoneum, liver and distant organ, lymphatic and vessel invasions, curability. Dukes' classification and plasma TIMP-1 concentration were significant. By multivariate analysis excluding patients with distant or peritoneal metastases, histological type, lymphatic invasions, lymph node metastasis and plasma TIMP-1 were retained in the final model. CONCLUSION These results suggested that plasma TIMP-1 may be a useful prognostic marker for survival in patients with colorectal carcinoma.
Post‐transcriptional control of expression of sFlt‐1, an endogenous inhibitor of vascular endothelial growth factor

Vascular endothelial growth factor (VEGF) is a major modulator of angiogenesis. Biological effects of VEGF are mediated by endothelial cell‐surface receptors, KDR and Flt‐1. Alternative Flt‐1 RNA processing, involving retention of intron 13 and the use of intronic cleavage‐polyadenylation signals, produces a secreted form of Flt‐1, “sFlt‐1,” that binds VEGF with high affinity and can inhibit VEGF signaling. To probe mechanisms controlling sFlt‐1 expression, we have cloned and sequenced Flt‐1 intron 13 from a mouse genomic library and located RNA processing signals potentially involved in sFlt‐1 mRNA formation. A minigene construct containing Flt‐1 intron 13 directed the expression of both secreted (i.e., cleaved/polyadenylated) and transmembrane (i.e., spliced) forms of Flt‐1 mRNA and protein. Using rapid amplification of 3′ cDNA ends (3′‐RACE) and quantitative PCR (QPCR) analysis to test the activity of intronic cleavage‐polyadenylation signals, we observed that multiple sites were utilized for sFlt‐1 mRNA processing in both native tissues and Flt‐1 minigene transfectants. In transfectants, the most distal signal was utilized preferentially. The potential for interaction between pathways leading to sFlt‐1 or full‐length Flt‐1 was evaluated using QPCR to measure relevant mRNAs after transfection with signal mutants. Decreased expression of sFlt‐1 mRNA in cleavage‐polyadenylation mutants was accompanied by reciprocal increases in full‐length Flt‐1 mRNA. Multiple sFlt‐1 mRNA species are formed that differ by up to 3.9 kb in their 3′‐untranslated regions (UTRs), which contain sites of potential regulatory importance. The reciprocity between sFlt‐1 and Flt‐1 mRNA expression suggests a novel post‐transcriptional mechanism by which sFlt‐1 protein production and, thereby, responsiveness to VEGF, may be modulated. © 2004 Wiley‐Liss, Inc.
A Post-Filtering Approach Based on Locally Linear Embedding Difference Compensation for Speech Enhancement

This paper presents a novel difference compensation post-filtering approach based on the locally linear embedding (LLE) algorithm for speech enhancement (SE). The main goal of the proposed post-filtering approach is to further suppress residual noises in SE-processed signals to attain improved speech quality and intelligibility. The proposed system can be divided into offline and online stages. In the offline stage, we prepare paired differences: the estimated difference of {SE-processed speech; noisy speech} and the ground-truth difference of {clean speech; noisy speech}. In the online stage, on the basis of estimated difference of a test utterance, we first predict the corresponding ground-truth difference based on the LLE algorithm, and then compensate the noisy speech with the predicted difference. In this study, we integrate a deep denoising autoencoder (DDAE) SE method with the proposed LLE-based difference compensation post-filtering approach. The experiment results reveal that the proposed post-filtering approach obviously enhanced the speech quality and intelligibility of the DDAE-based SE-processed speech in different noise types and signal-to-noise-ratio levels.
Menopausal hot flashes and insulin resistance

Objective Recent data have indicated that menopausal hot flashes may be a determinant for cardiovascular health. Therefore, we studied the impact of hot flashes on insulin resistance, one of the most powerful markers of cardiovascular health, in recently postmenopausal women. Methods We studied 143 recently postmenopausal (amenorrhea 6-36 mo) healthy and normal-weight women without previous hormone therapy use. The women prospectively recorded the number and severity of hot flashes for 2 weeks, and a validated total symptom score, the hot flash weekly weighted score, was calculated for each woman. Insulin resistance was assessed from fasting blood levels of glucose and insulin with the homeostasis model assessment. Results In 12 women, the assessment of insulin (n = 11) or glucose (n = 1) failed, and they were excluded from further analysis. Thus, hot flashes were absent in 19, mild in 32, moderate in 27, and severe in 53 women. The levels of glucose or insulin, or HOMA showed no differences between these groups, nor was insulin resistance related to the number or severity of hot flashes or to the levels of C-reactive protein or sex hormone–binding globulin. Overall, insulin resistance showed a positive association with body mass index (mean difference, 0.058; 95% CI, 0.015-0.102; P = 0.009) and a negative association with level of estradiol (mean difference, −0.002; 95% CI, −0.003 to −0.001; P = 0.009). Conclusions Insulin resistance may not be involved in hot flash–related changes in cardiovascular health. However, because of the small sample size, these findings need to be interpreted with caution.