Miracle-dz/UniFAR-FTUs huggingface dataset:
GWTC-2: Compact Binary Coalescences Observed by LIGO and Virgo During the First Half of the Third Observing Run

We report on gravitational wave discoveries from compact binary coalescences detected by Advanced LIGO and Advanced Virgo in the first half of the third observing run (O3a) between 1 April 2019 15:00 UTC and 1 October 2019 15:00. By imposing a false-alarm-rate threshold of two per year in each of the four search pipelines that constitute our search, we present 39 candidate gravitational wave events. At this threshold, we expect a contamination fraction of less than 10%. Of these, 26 candidate events were reported previously in near real-time through GCN Notices and Circulars; 13 are reported here for the first time. The catalog contains events whose sources are black hole binary mergers up to a redshift of ~0.8, as well as events whose components could not be unambiguously identified as black holes or neutron stars. For the latter group, we are unable to determine the nature based on estimates of the component masses and spins from gravitational wave data alone. The range of candidate events which are unambiguously identified as binary black holes (both objects $\geq 3~M_\odot$) is increased compared to GWTC-1, with total masses from $\sim 14~M_\odot$ for GW190924_021846 to $\sim 150~M_\odot$ for GW190521. For the first time, this catalog includes binary systems with significantly asymmetric mass ratios, which had not been observed in data taken before April 2019. We also find that 11 of the 39 events detected since April 2019 have positive effective inspiral spins under our default prior (at 90% credibility), while none exhibit negative effective inspiral spin. Given the increased sensitivity of Advanced LIGO and Advanced Virgo, the detection of 39 candidate events in ~26 weeks of data (~1.5 per week) is consistent with GWTC-1.
Vitamin A Supplementation Transiently Increases Retinol Concentrations in Extrahepatic Organs of Neonatal Rats Raised under Vitamin A–Marginal Conditions 1–3

Background: Vitamin A (VA; retinol) supplementation is recommended for children aged >6 mo in countries with high rates of malnutrition, but the distribution and retention of VA in body tissues have not been extensively explored. Objective: We sought to determine the distribution and retention of VA in tissues of neonatal rats raised under VA-marginal conditions. Methods: Sprague-Dawley neonatal rats ( n = 104; 63 males) nursed by mothers fed a VA-marginal diet (0.35 mg retinol equivalents/kg diet) were randomized and treated on postnatal day 4 with an oral dose of either VA (6 m g retinyl palmitate/g body weight) or canola oil as control. Pups ( n = 4/group) were killed at 13 time points from 30 min to 24 d after dose administration. The total retinol concentration and mass were determined in all collected organs. Results: In the control group, plasma VA was marginal (0.8 m mol/L), whereas liver VA was deﬁcient (<70 nmol/g). Nonetheless, the liver contained most ( ; 76%) of the total VA mass in the body, whereas extrahepatic nondigestive organs together contained ; 13%. Whiteadiposetissue(WAT),whichwasnearlyabsentbeforepostnatalday12,containedonly ; 1%. InVA-supplemented neonates,themeantotalretinolconcentrationsinallorgansweresigniﬁcantlygreaterthanincontrolpups. However, thisincrease lasted for only ; 1 d in most extrahepatic tissues, with the exception of WAT, in which it lasted 18 d. Conclusions: Extrahepatic organs in neonatal rats raised under VA-marginal conditions store relatively little VA, and the scarcity of adipose tissue may predispose neonates to a low-VA status. The effect of VA supplementation on VA content in most extrahepatic organs is transient. A more frequent supplementation along with other nutritional interventions may be necessary for maintaining a steady supply of retinol to the rapidly developing extrahepatic organs. J Nutr 2016;146:1953–60.
[Re] Stabilizing Off-Policy Q-Learning via Bootstrapping Error Reduction

Recent Reinforcement Learning(RL) algorithms have achieved great success on different tasks with the comparable performance with humans or sometimes surpassing human ability. Nevertheless, compared to the area of computer vision or NLP which can learn from large-scale datasets and have a generalizable model, the application of RL algorithms to the real-world is still limited since it requires active data collection. In principle, Off-policy RL algorithms such as Q-Learning can remedy this issue since it can learn from the dataset collected from any policy. However, in practice, off-policy Q-Learning is so sensitive to the training data distribution that it often fails to learn without data collection that directly comes from the interaction with environments.
Type II IFN Synthesis by Synergistic Effects of CD40 and In vivo and In vitro Regulation of Type I IFN

During cognate interaction with CD40 ligand (CD154)-expressing T cells, Ag-presenting accessory cells are activated for increased cytokine synthetic and costimulatory function. We examined whether CD40 modulates in vivo innate immune function over time, hypothesizing that distinct cytokine responses evolve to delayed microbial exposure. C3H/HeN mice pretreated with activating anti-CD40 Ab (FGK45) produced 10-fold more serum IFN- (cid:1) and IL-12 p70 to delayed, but not synchronous, challenge with LPS. A novel ﬁnding was that LPS-induced IFN- (cid:2) increased by 20-fold in mice pretreated for 24 h, but not 6 h orless, with anti-CD40. Anti-CD40-pretreated C57BL/6 RAG-2 (cid:3) / (cid:3) mice similarly increased IFN- (cid:2) responses to delayed LPS challenge, conﬁrming me-diation by innate immunity. Type I IFNR- and IFN- (cid:1) -deﬁcient mice treated with anti-CD40 failed to expand serum IFN- (cid:2) responses to LPS challenge. Combined pretreatment with anti-CD40 and anti-IFN- (cid:1) mAb showed that IFN- (cid:1) produced after anti-CD40 pretreatment, but before LPS challenge, was necessary for IFN- (cid:2) synthetic enhancement. Anti-CD40 also increased polyinosinic-polycytidylic acid (poly(I:C))-inducible IFN- (cid:2) by 5-fold in an IFN- (cid:1) -dependent fashion, but did not signiﬁcantly increase IFN- (cid:2) production to CpG or Pam 3 Cys challenges. Poly(IC)-stimulated splenocytes from anti-CD40-pretreated mice produced 4-fold more IFN- (cid:2) than controls and production associated with CD11c (cid:4) cells. Finally, rIFN- (cid:1) and anti-CD40 combined synergistically to increase poly(IC)-inducible IFN- (cid:2) synthetic capacity in bone marrow dendritic cells. We conclude that innate immune production of IFN- (cid:2) is cooperatively regulated by CD40 and IFN- (cid:1) acting on dendritic cells, suggesting a unique mechanism by which innate immune function evolves in response to speciﬁc adaptive immune signals. The Journal of Immunology, 2006, 176: 5995–6003.
The influence of a bottom camera in indoor ground-segmentation based obstacle avoiding performance for MAVs

Navigation in unknown indoor environments is a challenging task, requiring the avoidance of unknown obstacles. The available moving space is limited and the variety of potential obstacles is large. Active sensors that detect obstacles are heavy and power consuming. Monocular obstacle avoidance methods often require texture or a priori knowledge. This paper introduces a novel method to use just a single forward looking camera for avoiding obstacles. In particular, an approach is extended in which a Micro Air Vehicle (MAV) detects obstacles by recognizing the floor. The extension is to use not only the MAVs frontal images but also its bottom camera images for learning floor appearance. Color and texture information is retrieved from the front and bottom camera images and stored as features. The color features used are the HSV and RGB color space and their respective histogram distances between the front and bottom camera images. For texture, the difference in edgeness and Law’s energy measures histogram distances are used as features. These features are extracted from the front and bottom images and their distance is used to classify each pixel of the front image as belonging either to the ground or to an obstacle. This is first done with a priori information by training a Reduced Error Pruning (REP) tree for a single image, followed by training a REP tree for an entire dataset without bottom camera information and with bottom camera information. The best results without bottom camera information are obtained with the HSV features only and are 93.3% accurate. With bottom camera, the best results are also obtained for the HSV features and are 97.5% accurate. To eliminate the dependency on a priori information, two approaches are taken to segment the images. The first method is Ulrich’s image segmentation, which uses a trapezoid directly in front of the robot as a reference for obstaclefree space. The second approach is the detection of outliers with respect to bottom camera information, classifying the outliers as obstacles. Classifications using Ulrich on the same dataset are 59.4% accurate and with outlier 82.7%, when using HSV features. Based on this classification, a navigation controller is designed. The proposed solution is tested while navigating in a new untrained environment and shown to select the ideal navigation solution in 64 % of the cases, with 27 % neutral decision and 9 % wrong decision.
A Powerful Nomogram Based on the Novel D-Index to Predict Prognosis After Surgical Resection of Hepatocellular Carcinoma

Purpose: Conventional staging and scoring systems such as the Tumor, Node, and Metastasis; Cancer of the Liver Italian Program; Barcelona Clinic Liver Cancer; and Okuda have failed to predict overall survival (OS) in patients with resected primary hepatocellular carcinoma. Thus, we aimed to establish a novel D-index and nomogram to improve prognostic accuracy. Patients and Methods: We selected 396 patients who underwent liver resection between January 2007 and February 2015 at the First Affiliated Hospital of Wenzhou Medical University. These patients were randomly divided into the training and validation groups in a ratio of 7:3. Results: We generated a nomogram using five independent risk factors, including the D-index (calculated by total bilirubin × tumor size/the ratio of fat-to-muscle area 0.5 ) in the training set. The predictive performance of the nomogram was similar in both the training and validation cohorts according to the concordance index. The nomogram demonstrated the strongest predictive power for 1-year, 3-year, and 5-year OS, with the area under the receiving operating characteristic curve being 0.8486, 0.7785, and 0.752, respectively. The calibration curves exhibited stable capabilities in both cohorts. The stratification of the Kaplan-Meier curve was significant (P < 0.001). Conclusion: The associated nomogram of the D-index demonstrated a powerful and accurate predictive ability for OS in patients with primary hepatocellular carcinoma.
Industrial Logistics Performance of Thai Industry

Industrial Logistics Performance Indicators (ILPI) is used as an assessing tool for 27 logistics performance, developed for Thai industry. From 1,644 companies in the database collection, the study aims at providing individuality view of logistics performance of 5 industries, i.e., food, chemicals, rubber and plastic, machinery and equipment and electrical industries. As the industry and products vary, the paper is to explore key logistics characteristics as the over- and under- performance, outstanding from others. The findings are indicatives that each industry focus and pay attentions on which performances. The finding is also suggestive if ones must understand the industry or wish to support the industry in any measures.
Exploring structural sections in EDM DJ-created radio mixes with the help of automatic music descriptors

Disc Jockeys are the most likely the ultimate experts at mixing music to “move the crowd”. In this work, structural sections based on “levels of emotional experience” in electronic dance music (EDM) are investigated by analyzing DJ-created radio mixes using automatic music descriptors in order to get audio content information. Mixes are first manually annotated to categorise structural sections and then, their characteristics and patterns between them are investigated. Finally, various evaluations are performed to explore the accuracy with which a system could automatically detect, with the given information, the different sections within randomly chosen independent ten seconds excerpts. Results prove the reliability of the chosen descriptors to achieve a successful classification with moderate number of errors. Moreover, a solution for improving the prediction’s accuracy by taking in account patterns between structural sections is proposed.
LiVE approach: Lean integrated Value Engineering for construction industry

Purpose Increasing demand for the best value for client’s money necessitates waste reduction while enhancing the project functionality in construction industry. The purpose of this paper is to propose Lean integrated Value Engineering (LiVE) approach by establishing the synergy between Lean and Value Engineering (VE) concepts for construction industry. Design/methodology/approach A literature survey and in-depth un-structured interviews with six subject matter experts in three steps were used to investigate the synergy between Lean principles and VE job plan to develop LiVE approach for the construction industry. The gathered data were analysed using code-based content analysis and the LiVE approach was finally validated using interviews by two additional subject matter experts representing industry and academia. Findings Research findings established that there is a synergy between Lean principles and VE job plan. Accordingly, the study developed a LiVE approach, which specify client’s value, identify the value stream, make value flow without interruption, let the client pull functional requirements and pursue perfection during “value establishment”, “value analysis of functional requirements”, “value creativity”, “value evaluation”, “value development”, “value verification” and “value achievement” phases. Originality/value The novel LiVE approach will guide construction industry practitioners on how to integrate Lean concept with VE in order to reduce unnecessary costs and wastes, to enhance project functionality and ultimately to achieve value for client’s money.
microRNA-612 suppresses the malignant development of non-small-cell lung cancer by directly targeting bromodomain-containing protein 4

Background: Aberrant expression of microRNAs (miRNAs) in non-small-cell lung cancer (NSCLC) has been reported. Dysregulation of miRNAs exerts tumor-suppressing or tumor-promoting actions on the pathology and biological behaviors of NSCLC. miR-612 is associated with many types of human cancer; however, the expression, potential roles, and regulatory mechanisms of miR-612 in NSCLC remain unclear. Material and methods: Here, the expression level of miR-612 in NSCLC tissue specimens and a panel of cell lines were evaluated by RT-qPCR. Cell-Counting Kit 8, ﬂ ow cytometry, Transwell migration and invasion, and in vivo tumor growth assays were performed to determine the functional role of miR-612 in malignant phenotypes of NSCLC cells. The molecular mechanism underlying the tumor-suppressive roles of miR-612 in NSCLC was investigated. Results: miR-612 was expressed at low levels in NSCLC, and low miR-612 expression was signi ﬁ cantly correlated with TNM stage and lymph node metastasis. NSCLC patients with low miR-612 expression had shorter overall survival rate than those with high levels. Exogenous miR-612 expression decreased proliferation, migration, and invasion, and promoted apoptosis of NSCLC cells in vitro . miR-612 upregulation hindered NSCLC tumor growth in vivo . Bromodomain-containing protein 4 ( BRD4 ) was con ﬁ rmed as a direct target gene of miR-612 in NSCLC cells. BRD4 was obviously overexpressed in human NSCLC tissues and inverse correlated with miR-612 expression. Inhibition of BRD4 expression simulated the tumor-suppressive functions of miR-612 overexpression in NSCLC cells. Reintroduction of miR-612 expression abrogated the miR-612-mediated suppressive effects on NSCLC cells. BRD4 upregulation inhibited activation of the PI3K/Akt pathway in NSCLC cells in vitro and in vivo . Conclusion: This study supports the ﬁ rst evidence that miR-612 exerts tumor-suppressive roles in the aggressive behaviors of NSCLC cells in vitro and in vivo through direct targeting BRD4 and deactivating the PI3K/Akt pathway. Thus, miR-612 might be a promising target for anticancer therapies in patients with NSCLC. cells were identi analysis, and the results showed that miR-612 overexpression increased the apoptosis measure the migration and
Signaling 3 Inhibits Activation of NFATp Cutting Edge: Suppressor of Cytokine

Recent studies have suggested that signaling initiated by the activation of Ag receptors and signaling activated through cytokine receptors may be regulated by a common set of inhibitory proteins. Suppressor of cytokine signaling 3 (SOCS-3), which has previously been demonstrated to inhibit cytokine signaling, is induced on TCR ligation. Overexpression of SOCS-3 can inhibit transcription driven by the IL-2 promoter in response to T cell activation. This inhibitory activity corre-lates with the suppression of calcineurin-dependent dephosphorylation and activation of the IL-2 promoter binding transcription factor, NFATp. Infection of primary murine T cells with a retrovirus encoding SOCS-3 blocks their IL-2 production in response to activation. Interestingly, SOCS-3 was found to coimmunoprecipitate with the catalytic subunit of calcineurin. These studies suggest that SOCS-3 may regulate T cell function as part of a negative feedback loop. The Journal of Immunology, 2002, 168: 4277–4281. we Our results suggest
Author for correspondence (piccolo@civ.bio.unipd.it) Accepted 26 May 2010 SUMMARY The Smad ubiquitin ligase, Spemann Organizer and mesoderm patterning, TGF  signaling,

definition of embryonic potency and induction of specific cell fates are intimately linked to the tight control over TGF  signaling. Although extracellular regulation of ligand availability has received considerable attention in recent years, surprisingly little is known about the intracellular factors that negatively control Smad activity in mammalian tissues. By means of genetic ablation, we show that the Smad4 inhibitor ectodermin ( Ecto , also known as Trim33 or Tif1  ) is required to limit Nodal responsiveness in vivo. New phenotypes, which are linked to excessive Nodal activity, emerge from such a modified landscape of Smad responsiveness in both embryonic and extra-embryonic territories. In extra-embryonic endoderm, Ecto is required to confine expression of Nodal antagonists to the anterior visceral endoderm. In trophoblast cells, Ecto precisely doses Nodal activity, balancing stem cell self-renewal and differentiation. Epiblast-specific Ecto deficiency shifts mesoderm fates towards node/organizer fates, revealing the requirement of Smad inhibition for the precise allocation of cells along the primitive streak. This study unveils that intracellular negative control of Smad function by ectodermin/Tif1  is a
Intracranial administration of transforming growth factor- (cid:1) 3 increases fat oxidation in rats

Intracranial administration of transforming growth factor- (cid:1) 3 increases fat oxidation in rats. Am J Physiol Endocrinol Metab 283: E536–E544, 2002. ajpendo.00094. 2001. —The effects of intracranial transforming growth factor (TGF)- (cid:1) 3 on spontaneous motor activity and energy metabolism were examined in rats. After injection of TGF- (cid:1) 3 into the cisterna magna of the rat, spontaneous motor activity decreased signiﬁcantly for 1 h. The intracranial injection of TGF- (cid:1) 3 produced an immediate decrease in respiratory exchange ratio (RER). No signiﬁcant changes were observed in energy expenditure. TGF- (cid:1) 3 induced a signiﬁcant increase in total fat oxidation and a decrease in total carbohydrate oxidation. Furthermore, the serum substrates associated with fat metabolism were signiﬁcantly altered in rats injected with TGF- (cid:1) 3. Both lipoprotein lipase activity in skeletal muscle and the concentration of serum ketone bodies increased, suggesting that the increase in fat oxidation caused by TGF- (cid:1) 3 may have occurred in the liver and muscle. Intracranial injection of TGF- (cid:1) 3 appeared to evoke a switch in the energy substrates accessed in energy expenditure. These results suggest that the release of TGF- (cid:1) 3 in the brain exercise post hoc analysis. The means of more than three groups measured at the same point in time were compared by one-way ANOVA followed by Dunnett’s test.
Steady-state Growth of the Marine Diatom Thalassiosira pseudonana UNCOUPLED KINETICS OF NITRATE UPTAKE AND NITRITE PRODUCTION'

Seasonal studies of the vertical distribution of nitrate, nitrite, and phytoplankton in the oceans and studies using 15N as a tracer of nitrate metabolism indicate that the reduction of nitrate by phytoplankton is a source of nitrite in the upper waters of the ocean. To better understand this process, the relationship between nitrate uptake and nitrite production has been examined with continuous cultures of the small marine diatom Thalassiosira pseudonana. In a turbidostat culture, the rates of nitrite production by T. pseudonana increase with light intensity. This process is only loosely coupled to rates of nitrate assimilation since the ratio of net nitrite production to total nitrate assimilation increases with increased rates of growth. In continuous cultures where steady-state concentrations of nitrate and nitrite were varied, T. pseudonana produced nitrite at rates which increased with increasing concentrations of nitrate. Again, the rates of nitrite production were uncoupled from rates ofnitrate assimilation. The study was used to derive a mathematical description of nitrate and nitrite metabolism by T. pseudonanm The validity of this model was supported by the results of a study in which '5N-labeled nitrite was introduced into the continuous culture, and the model was used to examine patterns in distribution of nitrite in the Antarctic Ocean and the Sargasso Sea.
Modulated Model Predictve Control (M 2 PC) for a 3-Phase Active Rectifier

— One of the main issues of Model Predictive Control applied to Power Electronics Converters is the availability of selecting only a limited amount of converter switching states for waveforms generation, thus requiring a high switching frequency in order to achieve reasonable harmonic content. The nature of this control method also results in variable switching frequency, making filter design complicated. In order to overcome these issues, whilst still preserving all of the desired characteristics of MPC, this paper presents a novel Modulated Model Predictive Control, with the aim of obtaining a modulated waveform at the output of the converter without implementing an explicit modulation scheme. The proposed control technique is applied for the current control of a 2-Level 3-Phase inverter and validated, through simulations performed in Matlab/PLECS, in comparison with the classical Model Predictive Control, Dead Beat Control and PI control in a stationary reference frame. The control has been implemented and experimentally validated on a 2-Level 3-Phase active rectifier and compared to a traditional Model Predictive Control.