Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterizing Woody Breast Myopathy in a Meat Broiler Line by Heat Production, Microbiota, and Plasma Metabolites

Selection for quantitative traits in meat broilers such as breast yield and growth rate exert physiological pressure leading to ante mortem histological and biochemical alterations in muscle tissues. The poultry industry has recently witnessed a myopathy condition affecting Pectoralis major (breast muscle) of broilers, called woody breast (WB), an etiology still unclear to scientific community. A study was conducted to characterize the WB myopathy in a meat broiler line at its finishing phase (d 41) in terms of heat production (HP), microbiota and plasma metabolites. Two treatment groups were studied—WB affected (myopathy) and normal (non-myopathy) broiler; n = 20 in each group. Indirect calorimetry was utilized for HP measurement. Furthermore, body composition (BC) analysis was also performed using dual-energy x-ray absorptiometry (DEXA). Microbiota in ileal digesta was studied with PCR amplified 16s rRNA gene. LC-MS targeted metabolomics was performed to understand differential expression of plasma metabolites. Results showed that there was difference in fasting HP (P < 0.05) between these two treatment groups, with non-myopathy broiler producing more heat which was indicative of higher body protein content validated by higher protein: fat ratio by BC results. Less protein content in myopathy bird could be due to probable higher mixed muscle degradation occurring in lean tissue as marked by elevated 3-methylhistidine expression in plasma. Microbiota results showed unclassified Lactobacillus as predominant genus with higher abundance occurring in myopathy group; whereas at species level, L. acidipiscis was predominant bacteria for non-myopathy broiler. Differentially significant metabolites (P < 0.05) identified from plasma metabolome between these two treatment groups were homocysteine, cyclic GMP, trimethylamine N-oxide (TMAO), tyramine, carnitine, and acetylcarnitine, which were all associated to cardiovascular system. The findings suggest that more research in meat broilers could be opted toward delivering reduced vascularity issues to alleviate this myopathy condition.
Compliant Titin Isoform Content Is Reduced in Left Ventricles of Sedentary Versus Active Rats

A sedentary lifestyle is associated with increased cardiovascular risk factors and reduced cardiac compliance when compared to a lifestyle that includes exercise training. Exercise training increases cardiac compliance in humans, but the mechanisms underlying this improvement are unknown. A major determinant of cardiac compliance is the compliance of the giant elastic protein titin. Experimentally reducing titin compliance in animal models reduces exercise tolerance, but it is not known whether sedentary versus chronic exercise conditions cause differences in titin isoform content. We hypothesized that sedentary conditions would be associated with a reduction in the content of the longer, more compliant N2BA isoform relative to the stiffer N2B isoform (yielding a reduced N2BA:N2B ratio) compared to age-matched exercising controls. We obtained left ventricles from 16-week old rats housed for 12 weeks in standard (sedentary) or voluntary running wheel (exercised) housing. The N2BA:N2B ratio was decreased in the hearts of sedentary versus active rats (p = 0.041). Gene expression of a titin mRNA splicing factor, RNA Binding Motif 20 protein (RBM20), correlated negatively with N2BA:N2B ratios (p = 0.006, r = −0.449), but was not different between groups, suggesting that RBM20 may be regulated post-transcriptionally. Total phosphorylation of cardiac titin was not different between the active and sedentary groups. This study is the first to demonstrate that sedentary rats exhibit reduced cardiac titin N2BA:N2B isoform ratios, which implies reduced cardiac compliance. These data suggest that a lack of exercise (running wheel) reduces cardiac compliance and that exercise itself increases cardiac compliance.
A Preliminary Study on the Functional Benefits of Computerized Working Memory Training in Children With Pediatric Bipolar Disorder and Attention Deficit Hyperactivity Disorder

Twenty-nine pediatric patients (age range, 10–16 years) with working memory (WM) deficits, including children with pediatric bipolar disorder (PBD) with and without attention-deficit hyperactivity disorder (ADHD) comorbidity and children with ADHD, underwent a Cogmed WM training program. For both patient groups, WM performance on Cogmed tasks and on the Digit Span test improved significantly after training. Moreover, the PBD group improved on Trails Making Test A and on the Inhibition Scale, the Behavior Regulation Index, and the Global Executive Composite of the Behavioral Rating Inventory of Executive Function. The ADHD group improved significantly on the Trails Making Test B, the Spatial Span Test, and the Reading Fluency Test of the Woodcock–Johnson III, as well as on depressive symptoms. The present findings suggest that working memory training is beneficial not only in youths with ADHD but also in youths with PBD. They also show evidence of near and far transfer of WM improvement in these patients, although in different ways for the two patient groups. Future studies examining the mechanisms of cognitive remediation in pediatric patients will aid in creating tailored illness-specific cognitive interventions.
Empowering Executive Functions in 5- and 6-Year-Old Typically Developing Children Through Educational Robotics: An RCT Study

Educational Robotics (ER) is a new learning approach that is known mainly for its effects on scientific academic subjects such as science, technology, engineering, and mathematics. Recent studies indicate that ER can also affect cognitive development by improving critical reasoning and planning skills. This study aimed to quantify the ability of ER to empower Executive Functions (EF), including the ability to control, update, and program information, in 5- and 6-year-old children attending first grade, a crucial evolutionary window for the development of such abilities. A total of 187 typically developing children were enrolled and randomly allocated into two experimental conditions: A, for immediate ER training, and B, for waitlist. ER-Laboratories (ER-Lab) for small groups were organized at schools, using a child-friendly, bee-shaped robot called Bee-Bot® (Campus Store). Activities were intensive, enjoyable, and progressively more challenging over the 20 twice-weekly sessions. Outcome measures, based on standardized tests, were used to quantify the effects of ER on EF. Compared to the control group, the ER-Lab group showed significantly better ability to actively manipulate information in short-term memory and suppress automatic responses in favor of goal-appropriate actions. This RCT study provides the first quantitative evidence of the positive effects of ER activities for improving working memory and inhibition in the early school years.
Revealing a Novel Landscape of the Association Between Blood Lipid Levels and Alzheimer's Disease: A Meta-Analysis of a Case-Control Study

Objectives: Blood lipid profiles have been ambiguously reported as biomarkers of AD in recent years. This study was conducted to evaluate the correlation between blood lipid levels and AD in later-life and to explore the effectiveness and reliability of blood lipid profiles as biomarkers of AD. Methods: Database searching was conducted using PubMed, the Cochrane Library, EMBASE, and Medline. This study was designed following the Meta-analysis of Observational Studies in Epidemiology (MOOSE) criteria. Review Manager 5.3 (RevMan 5.3) software was adopted to perform meta-analysis evaluating the standard mean difference (SMD) with its 95% confidence intervals (CI). Results: A total of 5,286 participants were enrolled from 27 case–control studies in this meta-analysis. The pooled results demonstrated that total cholesterol (TC) level was significantly associated with AD in late-life (SMD = 0.17, 95% CI: [0.01, 0.32], P = 0.03), especially in the subgroup under 70 years old (SMD: 0.45, 95% CI: [0.11, 0.79], P = 0.01) and the subgroup of Western population (SMD: 0.29, 95% CI: [0.04, 0.53], P = 0.02). In the subgroup under 70 years old, the high-density lipoprotein cholesterol (HDL-C) level (SMD = −0.50, 95% CI: [−0.76, −0.25], P = 0.0001) and the low-density lipoprotein cholesterol (LDL-C) level (SMD = 0.59, 95% CI: [0.02, 1.16], P = 0.04) in the AD group were significantly lower and higher than in the control group, respectively. In the subgroup with a sample size larger than 100 subjects, the LDL-C level was significantly higher in AD patients than in the control elderly group (SMD = 0.31, 95% CI: [0.05, 0.56], P = 0.02). There was no significant association between triglyceride (TG) levels and AD in later-life (SMD = −0.00, 95% CI: [−0.12, 0.12], P = 1.00). Conclusion: TC can be a new predictive biomarker of AD or cognitive decline in later-life. Increased TC levels are found to be associated with an elevated risk of AD. Decreased HDL-C levels and increased LDL-C levels may relate to an elevated risk of AD in subjects aged 60–70. Further comprehensive researches will be necessary in the future.
Distribution modeling, soil properties, and variation in essential oils chemical composition of Rhanterium adpressum Coss. & Dur.

Abstract Modeling the distribution of Rhanterium adpressum, an endemic species from southwestern Algeria, and the interactions of soil’s chemical properties with the variability of chemical composition of its essential oils makes the objective of this study. Obtained MaxEnt model (AUC = 0.98) showed that the general distribution of genus Rhanterium established mainly by the contribution of eight bioclimatic variables derived from temperature and precipitation (90.5%). Projection of the model in future conditions until 2070 reveals that the habitats of this species will be very affected by climate changes. The analysis of 9 soil samples shows a sandy (77–96%), alkaline, and calcareous character with an electrical conductivity between 0.2 and 1.8 dS/m at 20°C. The chemical composition of terpenoids families during a period of 5 months was dominated by monoterpene hydrocarbons (70–90%) followed by oxygen monoterpenes (4.5–9.2%), hydrocarbon sesquiterpenes (1.6–9.9%), and oxygenated sesquiterpenes (4.3–7.2%). The variation of this composition in relation with phenological cycle and physicochemical properties of the soil was discussed.
The Financial Performance of European Companies: Explanatory Factors in the Context of Economic Crisis

Abstract Financial accounting information plays an important role in assessing and forecasting firms’ financial performance. But besides that, there are other external factors affecting the performance of firms, such as economic and financial crises, which cause imbalances over the economy and affects the business environment. Thus, based on financial statements data, in this paper, the determinants of financial performance are examined, and the impact of a financial crisis on these factors is analyzed, using the fixed and random effects panel estimators. A sample of non-financial firms from European countries considering annual data for the period of 2006 to 2015 was used for this research. The results achieved by panel data analysis show that a crisis exerts a significant positive effect over financial performance as well as liquidity, assets turnover, and labor productivity, meaning that firms tend to put in greater efforts to maintain financial performance in the face of a crisis. Financial performance is significantly and negatively influenced by leverage independently of the crisis effect, showing return on assets to be lower than the average interest rate.
Outcomes and Predictive Factors of Electroacoustic Stimulation Rehabilitation in Children With Limited Low-Frequency Hearing.

OBJECTIVE To evaluate the clinical feasibility and auditory benefits of hearing rehabilitation using electroacoustic stimulation (EAS) after cochlear implantation (CI) and to identify the predictive factors for successful EAS rehabilitation in children with limited low-frequency hearing. STUDY DESIGN Retrospective case review. SETTING Tertiary referral hospital. PATIENTS Seventeen children (21 ears) under the age of 15 years with residual low-frequency hearing who underwent CI using hearing preservation techniques. INTERVENTION Patients underwent CI using hearing preservation techniques, and the postoperative audiograms were obtained to evaluate the hearing preservation rate. EAS rehabilitation was applied in patients with successful low-frequency hearing preservation. OUTCOME MEASURES Improvements in speech perception in both quiet and noise conditions were compared between the EAS mode and the CI-only mode. The predictive factors for successful EAS rehabilitation in children were analyzed. RESULTS Functional low-frequency residual hearing less than or equal to 85 dB at 250 and 500 Hz was achieved postoperatively in six of 21 ears, and successful EAS rehabilitation was possible in nine of 21 ears. Better speech perception scores were observed in quiet conditions using the EAS mode compared with the CI-only mode, although the difference did not reach statistical significance. Significantly, better scores were observed in noise conditions with the EAS mode compared with the CI-only mode. Postoperative low-frequency pure-tone average was the only significant predictive factor of successful EAS rehabilitation. CONCLUSION CI surgery using hearing preservation techniques with EAS rehabilitation should be performed in children, even in patients with limited residual hearing, to improve auditory outcomes.
Tannins, novel inhibitors of the volume regulation and the volume-sensitive anion channel

Abstract The volume-sensitive outwardly rectifying anion channel (VSOR) is a key component of volume regulation system critical for cell survival in non-isosmotic conditions. The aim of the present study was to test the effects of four tannin extracts with defined compositions on cell volume regulation and VSOR. Preparation I (98% of hydrolysable tannins isolated from leaves of sumac Rhus typhina L.) and Preparation II (100% of hydrolysable tannins isolated from leaves of broadleaf plantain Plantago major L) completely and irreversibly abolished swelling-activated VSOR currents in HCT116 cells. Both preparations profoundly suppressed the volume regulation in thymocytes with half-maximal effects of 40.9 μg/ml and 12.3 μg/ml, respectively. The inhibition was more efficient at lower concentrations but reverted at higher doses due to possible non-specific membrane-permeabilizing activity. Preparations III and IV (54,7% and 54.3% of hydrolysable tannins isolated, respectively, from roots and aboveground parts of Fergana spurge Euphorbia ferganensis B.Fedtch) inhibited VSOR activity in a partially reversible manner and suppressed the volume regulation with substantially higher half-maximal doses of 270 and 278 μg/ml, respectively, with no secondary reversion at higher doses. Hydrolysable tannins represent a novel class of VSOR channel inhibitors with the capacity to suppress the cell volume regulation machinery.
Entrepreneurship and Income Inequality: A Dynamic Spatial Panel Data Analysis

Abstract This paper extends the empirical debate of Ragoubi and El Harbi (2018) on the dynamic relationship between entrepreneurship and income inequality. Using a dynamic spatial panel data analysis for both 33 high-income countries and 39 middle-income and low-income countries over the period 2004–2014, the main empirical findings are summarised as follows. First, the results indicate that entrepreneurship is a spatial and persistent phenomenon. Second, there is strong support for the existence of an inverted U-shaped relationship between entrepreneurship and income inequality espoused by the Kuznets Curve hypothesis for middle-income and low-income countries. Third, the interaction between income inequality and income per capita has a significant negative effect on the entrepreneurial activity for middle-income and low-income countries. Fourth, a significant positive association is found between the interaction variable and entrepreneurship for high-income countries. Fifth, the findings show evidence of significant positive and negative short-run direct effects of income inequality on the entrepreneurial activity for middle-income and low-income countries. Finally, there are significant negative short-run spillover effects of income inequality on the entrepreneurial activity for middle-income and low-income countries.
Prediction of soil properties with machine learning models based on the spectral response of soil samples in the near infrared range

Abstract One of the basic methods for soil analysis time and cost reduction is using soil sample spectral response in laboratory conditions. The problem with this method lies in determining the relationship between the shape of the soil spectral response and soil physical or chemical properties. The LUCAS soil database collected by the EU’s ESDAC research centre is good material to analyse the relationship between the soil properties and the near infrared (NIR) spectral response. The modelling described in the paper is based on these data. The analysis of the impact of soil properties configuration on absorbance levels in various NIR spectrum ranges was conducted using the stepwise regression models with the properties, properties squared and products of properties being explanatory variables. The analysis of partial correlation of soil properties values with absorbance values and absorbance derivative in the entire spectral range was conducted in order to evaluate the impact of the absorbance transformation (the first derivative of absorbance vector) on the change of significance of relationship with properties values. The Multi Layer Perceptron (MLP) models were used to estimate the absorbance relationship with single soil features. Soil property modelling based on the selection and transformation algorithm of raw values and first and second absorbance derivatives was also conducted along with the suitability evaluation of such models in building digital soil maps. The absorbance is affected by a limited number of tested soil features like pH, texture, content of carbonates, SOC, N, and CEC; P and K contents have, in case of this research, a negligible impact. The NIR methodology can be suitable in conditions of limited soil variation and particularly in development of thematic soil maps.
Assessing the accuracy of existing forced alignment software on varieties of British English

Abstract This paper presents an analysis of the performance and usability of automatic speech processing tools on six different varieties of English spoken in the British Isles. The tools used in the present study were developed for use with Mainstream American English, but we demonstrate that their forced alignment functionality nonetheless performs extremely well on a range of British varieties, encompassing both careful and casual speech. Where phone boundary placement is concerned, substantial errors in alignment occur infrequently, and although small displacements between aligner-placed and human-placed phone boundaries are found regularly, these will rarely have a significant effect on measurements of interest for the researcher. We demonstrate that gross phone boundary placement errors, when they do arise, are particularly likely to be introduced in fast speech or with varieties that are radically different from Mainstream American English (e.g. Scots). We also observe occasional problems with phonetic transcription. Overall, we advise that, although forced alignment software is highly reliable and improving continuously, human confirmation is needed to correct errors which can displace entire stretches of speech. Nevertheless, sociolinguists can be assured that the output of these tools is generally highly accurate for a wide range of varieties.
Beyond Length: Investigating Dependency Distance Across L2 Modalities and Proficiency Levels

Abstract As an important index of working memory burden and syntactic difficulty, Dependency Distance (DD) has been fruitfully applied in the context of Second Language Acquisition (SLA) to both native and non-native language production. Recent research has focused on DD as a predictor of writing performance across different proficiencies, while the other modality of second language (L2) performance – speaking – has been largely neglected. Moreover, while previous results reported significant positive correlations between DD and writing proficiency, a lack of control for important variables such as sentence/text length may have potentially inflated the outcomes of the analyses. In this study, we examine the effects of DD across the different modalities and proficiency levels, controlling for the effects of text and sentence lengths. Results from statistical analysis show that the mean DD of L2 writing is significantly shorter than L2 speech production, indicating that L2 writing may be a cognitively more demanding task than L2 speaking. Additionally, while significant statistical differences in DD were found across proficiency levels in both L2 writing and speech, the significance disappeared after controlling for sentence and text length. The implications of the present study for future research on DD in SLA are discussed.
Food Preference of Oryzaephilus Surinamensis (Coleoptera: Silvanidae) to Different Types of Plant Products

Abstract Oryzaephilus surinamensis is one of the stored product insect that commonly found in Malaysia. The biological study through host range or food preferences of O. surinamensis is important for the development of sustainable management practice to control its infestation. The objective of this study was to identify the food preference of O. surinamensis to different plant products in relation to food type and moisture content. Twenty adult of O. surinamensis were exposed to three different group of food; dried fruits (date, raisin, apricot, fig), grain/cereals (rice, barley, oat grout, dried maize), and nuts (almond, ground nut, walnut, cashew nut) for 240h in laboratory Kulliyyah of Science, IIUM Kuantan. Moisture content in each food was also measured. It was found out that the most preferred food by O. surinamensis is oat groat of cereal grain group with medium level of moisture content. Further analysis on food moisture suggested that under current experimental conditions (temperature of 27℃ and 64% relative humidity within 240h of exposure), food moisture content does not affect pest infestation and distribution.
3‐D printed spectacles: potential, challenges and the future

Three‐dimensional (3‐D) printing offers the potential to custom‐produce a wide range of manufactured objects and improve manufacturing processes. The additive manufacturing process involves material (resin, metal, ceramics or biological cells) being deposited layer upon layer, which is fused to create a 3‐D object. While 3‐D printing has been readily available in the aerospace and automotive industries, and is being used increasingly in the medical field, its potential for optometry and ophthalmic optics has rarely been discussed in depth. 3‐D printing of spectacles has the potential to provide customised experiences, to cater for those who do not fit standardised frames or for those with irregular prescriptions, and to reduce delivery times and inventory with the opportunity of increasing access to underserved populations. Here we review available 3‐D printing technologies, and the current 3‐D printed spectacle market, including testing three commercially available spectacle frames to assess compliance with ISO:12870 standards. The article then explores the challenges faced and environmental impact of implementing 3‐D printing of spectacles.