Miracle-dz/UniFAR-FTUs huggingface dataset:
Injury Rate in TackleBar Football

Background: As football comes under greater scrutiny because of concussions and other injuries, many people are searching for safer alternatives, especially for youth athletes. The injury rate in TackleBar football, one such alternative, is not currently known. Purpose: To describe TackleBar football and calculate its injury rate over a single season to compare it with both traditional tackle and flag football. Study Design: Descriptive epidemiology study. Methods: TackleBar football was described, and injuries of male athletes (age range, 9-14 years) participating in TackleBar football were tracked over the course of a season (August 5 through October 27, 2018) and compared with published injury rates for traditional tackle and flag football. Results: The overall injury rate of TackleBar football was found to be 0.31 per 1000 athlete-exposures (AEs), which is lower than youth tackle (2.25-2.60/1000 AEs) and flag (5.77/1000 AEs) football. Conclusion: TackleBar football may represent a reasonable alternative to tackle and flag football with regard to injuries.
Spatial Distribution of Noninvasive Break Up Times and Clinical Relevance in Healthy Participants and Mild Dry Eye

Purpose Noninvasive keratograph break up times (NIKBUTs) are preferred to dye-based methods to evaluate tear stability in translational medicine. We analyzed the NIKBUTs in different regions of the precorneal tear by using a common imaging technology and explored potential correlations with clinical parameters. Methods We tested NIKBUTs of 120 participants (62.5% females, aged 61.0 ± 13.8 years) with the Keratograph 5M, with standardized symptoms, ocular surface evaluation, and tear lipid layer interferometry. NIKBUTs were obtained from color maps in up to 165 spatial zones corresponding to 7 concentric rings. Results The lowest NIKBUT of tested zones averaged 7.8 ± 7.4 seconds (median, 4.5; range, 1.5–24 seconds), with the lowest NIKBUT measuring <2 seconds in many inferior zones. A mean of 5 zones had broken up by 2 seconds compared to a mean of about 50 zones by 10 seconds. NIKBUTs in specific inferior peripheral zones were significantly directly correlated to tear lipid thicknesses. The receiver operating characteristics for detecting reduced tear lipid thickness were better than overall NIKBUTs for participants with readings in these zones. Weaker correlations of NIKBUTs with symptoms were observed in two other zones. Overall, the NIKBUT displayed by keratograph was not significantly associated with any clinical parameters. Conclusions Decreased NIKBUTs in specific peripheral locations may be associated with lower lipid thicknesses. Future measurements of NIKBUTs should ideally be determined in smaller defined zones than current maps. Translational Relevance An understanding of how to evaluate tear stability allows a more robust clinical evaluation of new drugs and medical devices for dry eye.
Protura from Hainan Island, China: new species, checklist and distribution

Abstract More than 1500 proturan specimens from Hainan Island are systematically studied. An annotated list of all species of Protura from Hainan Island is provided and their geographical distribution is discussed. The genus Paracondeellum is reported from Hainan Island for the first time, and Paracondeellum paradisumsp. nov. is described. The type species Paracondeellum dukouense (Tang & Yin, 1988) is redescribed based on syntype, and the lectotype and paralectotype are designated. The characters of the genus Paracondeellum are redefined, and the two known species are compared in detail. The Protura fauna of Hainan Island is mainly composed of species from the Oriental region, with 91% of the species belonging to the families Berberentulidae and Eosentomidae.
Prolonged Duration Topical Corneal Anesthesia With the Cationic Lidocaine Derivative QX-314

Purpose Topical corneal local anesthetics are short acting and may impair corneal healing. In this study we compared corneal anesthesia and toxicity of topically applied N-ethyl lidocaine (QX-314) versus the conventional local anesthetic, proparacaine (PPC). Methods Various concentrations of QX-314 and 15 mM (0.5%) PPC were topically applied to rat corneas. Corneal anesthesia was assessed with a Cochet-Bonnet esthesiometer at predetermined time points. PC12 cells were exposed to the same solutions to assess cytotoxicity. Repeated topical corneal administration in rats was then used to assess for histologic evidence of toxicity. Finally, we created uniform corneal epithelial defects in rats and assessed the effect of repeated administration of these compounds on the defect healing rate. Results QX-314 (15 mM) and PPC (15 mM) caused similar total duration (114 ± 17 and 87 ± 16 minutes, respectively; P = 0.06) of anesthesia. The depth of anesthesia was similar between these low-dose groups at 15 minutes after application (1.8 ± 0.3- and 2.0 ± 0.8-cm filament lengths). QX-314 (100 mM) provided more prolonged corneal anesthesia (174 ± 13 minutes; P < 0.0001), with improved depth at 15 minutes (0.7 ± 0.3-cm filament length; P = 0.007). All tested concentrations of QX-314 demonstrated similar or less toxicity than 0.5% PPC. Conclusions Topical administration of QX-314 is effective for corneal anesthesia and demonstrates no histologic signs of local toxicity in a rodent model. In higher concentrations, QX-314 provides more than twofold the duration of anesthetic effect than does 0.5% PPC. Translational Relevance Our study reveals a clinically relevant compound providing prolonged duration topical corneal anesthesia.
Violence against children in Latin America and the Caribbean: What do available data reveal about prevalence and perpetrators?

ABSTRACT Objective. To describe the prevalence of recent physical, sexual, and emotional violence against children 0 – 19 years of age in Latin America and the Caribbean (LAC) by age, sex, and perpetrator. Methods. A systematic review and analysis of published literature and large international datasets was conducted. Eligible sources from first record to December 2015 contained age-, sex-, and perpetrator-specific data from LAC. Random effects meta-regressions were performed, adjusting for relevant quality covariates and differences in violence definitions. Results. Seventy-two surveys (2 publications and 70 datasets) met inclusion criteria, representing 1 449 estimates from 34 countries. Prevalence of physical and emotional violence by caregivers ranged from 30% – 60%, and decreased with increasing age. Prevalence of physical violence by students (17% – 61%) declined with age, while emotional violence remained constant (60% – 92%). Prevalence of physical intimate partner violence (IPV) ranged from 13% – 18% for girls aged 15 – 19 years. Few or no eligible past-year estimates were available for any violence against children less than 9 years and boys 16 – 19 years of age; sexual violence against boys (any age) and girls (under 15 years); IPV except for girls aged 15 – 19 years; and violence by authority figures (e.g., teachers) or via gangs/organized crime. Conclusion. Past-year physical and emotional violence by caregivers and students is widespread in LAC across all ages in childhood, as is IPV against girls aged 15 – 19 years. Data collection must be expanded in LAC to monitor progress towards the sustainable development goals, develop effective prevention and response strategies, and shed light on violence relating to organized crime/gangs.
Identification of key genes and multiple molecular pathways of metastatic process in prostate cancer

Background Cancer metastasis is well known as the most adverse outcome and the major cause of mortality in cancer patients, including prostate cancer (PCa). There are no credible predictors, to this day, that can reflect the metastatic ability of localized PCa. In the present study, we firstly identified the differentially expressed genes (DEGs) and molecular pathways involved in the metastaic process of PCa by comparing gene expressions of metastaic PCa with localized PCa directly, with the purpose of identifying potential markers or therapeutic targets. Methods The gene expression profiles (GSE6919 and GSE32269) were downloaded from the Gene Expression Omnibus database, which contained 141 tissue samples, including 87 primary localized PCa samples and 54 metastaic PCa samples. After data processing, DEGs were identified by R language using the Student’s t-test adjusted via the Beniamini–Hochberg method. Subsequently, the gene ontology functional and pathway enrichment analyses of DEGs were performed and the protein–protein interaction network was constructed. Hub genes were identified using the plug-in cytoHubba in Cytoscape software by MCC and degree. Furthermore, validation and prognostic significance analysis of the hub genes were performed by UALCAN and gene expression profiling interactive analysis (GEPIA). Results A total of 90 DEGs were identified between localized and metastaic PCa, which consisted of 47 upregulated and 43 downregulated genes. The enriched functions and pathways of the DEGs include catabolic process, cell cycle, response to steroid hormone, extracellular matrix (ECM)-receptor interaction and vascular smooth muscle contraction. A total of 10 genes were identified as hub genes and biological process analysis of hub genes showed that cell cycle phase, cell division, and mitotic cell cycle process were mainly enriched. The expression of hub genes were confirmed in metastaic PCa when compared with localized PCa tissues by The Cancer Genome Atlas database. Moreover, the disease-free survival analysis of hub genes revealed that these genes may play an important role in invasion, progression or recurrence. Therefore, these hub genes might be the key genes contributed to tumor progression or metastasis in PCa and provide candidate therapeutic targets for PCa. Conclusions The present study identified some DEGs between localized and metastaic PCa tissue samples. These key genes might be potential therapeutic targets and biomarkers for the metastaic process of PCa.
Combining simulation modeling and stable isotope analyses to reconstruct the last known movements of one of Nature’s giants

The spatial ecology of rare, migratory oceanic animals is difficult to study directly. Where incremental tissues are available, their chemical composition can provide valuable indirect observations of movement and diet. Interpreting the chemical record in incremental tissues can be highly uncertain, however, as multiple mechanisms interact to produce the observed data. Simulation modeling is one approach for considering alternative hypotheses in ecology and can be used to consider the relative likelihood of obtaining an observed record under different combinations of ecological and environmental processes. Here we show how a simulation modeling approach can help to infer movement behaviour based on stable carbon isotope profiles measured in incremental baleen tissues of a blue whale (Balaenoptera musculus). The life history of this particular specimen, which stranded in 1891 in the UK, was selected as a case study due to its cultural significance as part of a permanent display at the Natural History Museum, London. We specifically tested whether measured variations in stable isotope compositions across the analysed baleen plate were more consistent with residency or latitudinal migrations. The measured isotopic record was most closely reproduced with a period of residency in sub-tropical waters for at least a full year followed by three repeated annual migrations between sub-tropical and high latitude regions. The latitudinal migration cycle was interrupted in the year prior to stranding, potentially implying pregnancy and weaning, but isotopic data alone cannot test this hypothesis. Simulation methods can help reveal movement information coded in the biochemical compositions of incremental tissues such as those archived in historic collections, and provides context and inferences that are useful for retrospective studies of animal movement, especially where other sources of individual movement data are sparse or challenging to validate.
Differences in tail feather growth rate in storm-petrels breeding in the Northern and Southern hemisphere: a ptilochronological approach

Moulting and breeding are costly stages in the avian annual cycle and may impose trade-offs in energy allocation between both stages or in their timing. Here, we compared feather growth rates (FGR) of rectrices in adults between two pairs of small pelagic Procellariiformes species differing in moult-breeding strategies: the European storm-petrel Hydrobates pelagicus and Leach’s storm-petrel Oceanodroma leucorhoa breeding in the Northern Hemisphere (Faroe Islands), showing moult-breeding overlap in tail feathers; and the Wilson’s storm-petrel Oceanites oceanicus and black-bellied storm-petrel Fregetta tropica, breeding in the Southern Hemisphere (South Shetlands), temporally separating moult and breeding. We used ptilochronology (i.e., feather growth bar width) to reconstruct FGR reflecting relative energy availability during moult. Based on previous research, we expected positive correlations between feather length (FL) and FGR. Additionally, we expected to find differences in FGR relative to FL between the moult-breeding strategies, where a relatively higher FGR to FL indicates a higher energy availability for moult. To investigate if energy availability during moult in the studied species is similar to species from other avian orders, we used FGR and FL found in literature (n = 164) and this study. We fitted a phylogenetic generalized least squares (PGLS) model to FGR with FL, group (i.e., Procellariiformes vs. non-Procellariiformes) and the interaction FL * group as predictors. As it has been suggested that Procellariiformes may form two growth bars per 24 h, we fitted the same model but with doubled FGR for Procellariiformes (PGLSadj). The group term was significant in the PGLS model, but was not in the PGLSadj model, confirming this suggestion. Individually predicted FGR by the PGLSadj model based on FL, showed that the Southern species have a significantly higher FGR relative to FL compared to the Northern species. Additionally, we found no correlation between FL and FGR in the Northern species, and a positive correlation between FL and FGR in the Southern species, suggesting differences in the trade-off between feather growth and size between species from both hemispheres. The observed differences between the Northern and Southern species may be caused by different moult-breeding strategies. The Southern species may have had more energy available for moult as they are free from breeding duties during moult, while the Northern species may have had less free energy due to a trade-off in energy allocation between breeding and moulting. Our study shows how different moult-breeding strategies may affect relative nutritional condition or energy allocation during moult of migratory pelagic seabirds.
Up-regulated Wnt1-inducible signaling pathway protein 1 correlates with poor prognosis and drug resistance by reducing DNA repair in gastric cancer

BACKGROUND Wnt1-inducible signaling pathway protein 1 (WISP1) is upregulated in several types of human cancer, and has been implicated in cancer progression. However, its clinical implications in gastric cancer (GC) remain unclear. AIM To explore the expression pattern and clinical significance of WISP1 in GC. METHODS Public data portals, including Oncomine, The Cancer Genome Atlas database, Coexpedia, and Kaplan-Meier plotter, were analyzed for the expression and clinical significance of WISP1 mRNA levels in GC. One hundred and fifty patients who underwent surgery for GC between February 2010 and October 2012 at the Affiliated Hospital of Jiangnan University were selected for validation study. WISP1 levels were measured at both the mRNA and protein levels by RT-qPCR, Western blot analysis, and immunohistochemistry (IHC). In addition, the in situ expression of WISP1 in the GC tissues was determined by IHC, and the patients were accordingly classified into high- and low-expression groups. The correlation of WISP1 expression status with patient prognosis was then determined by univariate and multivariate Cox regression analyses. WISP1 was knocked down by RNA interference. The 50% inhibitory concentration of oxaliplatin was detected by CellTiter-Blue assay. RESULTS WISP1 levels at both the mRNA and protein levels were remarkably upregulated in GC tissues compared to normal tissues. Moreover, IHC revealed that WISP1 expression was associated with T stage and chemotherapy outcome, but not with lymph node metastasis, age, gender, histological grade, or histological type. GC patients with high WISP1 expression showed a poor overall survival. Multivariate survival analysis indicated that WISP1 was an important prognostic factor for GC patients. Mechanistically, knock-down of WISP1 expression enhanced sensitivity to oxaliplatin by reducing DNA repair and enhancing DNA damage. CONCLUSION Significantly upregulated WISP1 expression is associated with cancer progression, chemotherapy outcome, and prognosis in GC. Mechanistically, knock-down of WISP1 expression enhances oxaliplatin sensitivity by reducing DNA repair and enhancing DNA damage. WISP1 may be a potential therapeutic target for GC treatment or a potential biomarker for diagnosis and prognosis.
Barriers to Healthcare Access for Members of the Bronx Ghanaian Immigrant Muslim Community in New York City

Barriers to Healthcare Access for Members of the Bronx Ghanaian Immigrant Muslim Community in New York City by Adam A. Musah MS, City College of New York (CUNY), 2003 MPA, New York University (NYU), 2001 BS, Lehman College (CUNY), 1998 AS, Bronx Community College (CUNY), 1996 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Health Services Administration
An ontology alignment hybrid method based on decision rules

: In this paper, we propose a hybrid approach based on the extraction of decision rules to refine the alignment results due to the use of three alignment strategies. This approach contains two phases: training phase which uses structural similarity, element similarity, instance-based similarity and C4.5 algorithms to extract decision rules, and evaluation phase which refines discovered alignment by three alignment strategies using extracted decision rules. This approach is compared with the best systems according to benchmark OAEI 2016: Framework for Ontology Alignment and Mapping (FOAM), A Dynamic Multistrategy Ontology Alignment Framework (RIMOM), AgreementMakerLight and Yet Another Matcher-Biomedical Ontologies (YAM-BIO), the proposed method gives good results (good recall, precision and F-measure). Experimental results show that the proposed approach is effective.
CAVRN: An Exploration and Evaluation of a Collective Audience Virtual Reality Nexus Experience

The virtual reality ecosystem has gained momentum in the gaming, entertainment, and enterprise markets, but is hampered by limitations in concurrent user count, throughput, and accessibility to mass audiences. Based on our analysis of the current state of the virtual reality ecosystem and relevant aspects of traditional media, we propose a set of design hypotheses for practical and effective seated virtual reality experiences of scale. Said hypotheses manifest in the Collective Audience Virtual Reality Nexus (CAVRN), a framework and management system for large-scale (30+ user) virtual reality deployment in a theater-like physical setting. A mixed methodology study of CAVE, an experience implemented using CAVRN, generated rich insights into the proposed hypotheses. We discuss the implications of our findings on content design, audience representation, and audience interaction.
Mantis: A Scalable, Lightweight and Accessible Architecture to Build Multiform Force Feedback Systems

Mantis is a highly scalable system architecture that democratizes haptic devices by enabling designers to create accurate, multiform and accessible force feedback systems. Mantis uses brushless DC motors, custom electronic controllers, and an admittance control scheme to achieve stable high-quality haptic rendering. It enables common desktop form factors but also: large workspaces (multiple arm lengths), multiple arm workspaces, and mobile workspaces. It also uses accessible components and costs significantly less than typical high-fidelity force feedback solutions which are often confined to research labs. We present our design and show that Mantis can reproduce the haptic fidelity of common robotic arms. We demonstrate its multiform ability by implementing five systems: a single desktop-sized device, a single large workspace device, a large workspace system with four points of feedback, a mobile system and a wearable one.
Noninvasive Estimation of Left Ventricular Diastolic Filling Pressure From Doppler Tei Index

Background. Discrepancies between LV function and its filling pressure are typically characterized with severe dysfunction and normal filling pressure, suggesting reduced preload. Reduced preload can cause lower early to late diastolic mitral flow velocity ratio (E/A) on the Doppler echocardiogram. Therefore, we hypothesized that the relation between LV function and filling pressure is poorer in patients with mitral flow E/A < 1.0, however, the same relation is better in those with E/A ≥1.0. Objectives. The present study sought to investigate and compare the relation between LV filling pressure and indices of LV function, including the recently proposed Doppler Tei index, between patients with mitral flow E/A < 1.0 and those with the E/A ≥ 1.0. Methods. LV end-diastolic and mid-diastolic (before atrial contraction: pre-A) pressures were directly measured by catheterization in 74 consecutive patients with normal sinus rhythm. Tei index was measured from pulsed Doppler LV inflow and outflow velocity recordings, as the sum of isovolumetric contraction and relaxation time divided by LV ejection time. Indices of cardiac function including LV end-diastolic and end-systolic volumes, LV ejection fraction, left atrial dimension, mitral flow E/A, deceleration time of E velocity, and its slope were also measured by Doppler echocardiography.Results. In all subjects, there were no significant or relatively weak correlations between the LV filling pressures and indices of LV function (r2 = 0.05 ∼ 0.27, N.S. ∼ p < 0.0001). In patients with E/A < 1.0, the correlations were not significant for all indices of LV function. However, multiple indices of LV function, especially the Tei index, showed significant and better correlations with both LV end-diastolic and pre-A pressures (r2 = 0.66 and 0.63, p < 0.0001, respectively). Conclusions. Correlations between LV filling pressure and indices of LV function are worse and not significant in patients with mitral flow E/A < 1.0, however, the correlations are better and significant in patients with the E/A ≥ 1.0. Indices of LV function, especially Tei index, allows noninvasive estimation of LV diastolic filling pressure in patients with mitral E/A ≥ 1.0.