Miracle-dz/UniFAR-FTUs huggingface dataset:
Hybrid Particle Swarm Optimization and K-Means Analysis for Bridge Clustering Based on National Bridge Inventory Data

AbstractBecause of budget constraints for maintaining highway bridges in the United States, it is necessary to accurately monitor bridge structures so that repair and rehabilitation strategies can be performed. In this paper, an optimization approach based on the hybrid of the metaheuristic particle swarm optimization and the k-means method (KPSO) in data clustering is presented. The goal is to group bridges by similar structural deficiency attributes by minimizing the sum of squares error associated with assigning data points to each cluster and the determination of the most suitable number of clusters. The presented approach was compared to the basic version of particle swarm optimization (PSO) and the traditional clustering method k-means. The algorithms were tested using the National Bridge Inventory (NBI) database. The results show that KPSO provides better results in terms of the objective function as well as showing an opportunity to implement optimization techniques for data analysis in civil infr.
Learning VMware vRealize Automation

Learn the fundamentals of vRealize Automation to accelerate the delivery of your IT services About This BookLearn to install the vRealize Automation product in a distributed architecture using a load balancerPlan backup and recovery strategies for every vRealize automation component Use vRealize Automation to manage applications and improve operational efficiency using this simple and intuitive guide Who This Book Is For This book is for anyone who wants to start their journey with vRealize Automation. It is your one-stop instruction guide to installing and configuring a distributed setup using NSX load balancer. Regardless of whether or not you have used vRealize Automation before, following the steps provided in each chapter will get you started with the product. What You Will Learn Understand the basic building blocks of vRealize Automation before embarking on the journey of installation Familiarize yourself with the requirements and steps that need to be performed during the first phase of the distributed installation Carry out a functional validation of the first phase of installation before completing the installation Build a blueprint for vSphere endpoint, an essential step for a successful deployment of a service catalog Create, configure, and deploy tenants, endpoints, blueprints, and the service catalogGet to grips with the failover process for all components in vRealize Automation Learn to configure the NSX loadbalancer for vRealize Orchestrator for high availabilityLeverage ASD to develop XaaS (Anything as a Service) in vRealize Automation to deliver valuable competenceIn Detail With the growing interest in Software Defined Data Centers (SDDC), vRealize Automation offers data center users an organized service catalog and governance for administrators. This way, end users gain autonomy while the IT department stays in control, making sure security and compliance requirements are met. Learning what each component does and how they dovetail with each other will bolster your understanding of vRealize Automation. The book starts off with an introduction to the distributed architecture that has been tested and installed in large scale deployments. Implementing and configuring distributed architecture with custom certificates is unarguably a demanding task, and it will be covered next. After this, we will progress with the installation. A vRealize Automation blueprint can be prepared in multiple ways; we will focus solely on vSphere endpoint blueprint. After this, we will discuss the high availability configuration via NSX loadbalancer for vRealize Orchestrator. Finally, we end with Advanced Service Designer, which provides service architects with the ability to create advanced services and publish them as catalog items. Style and approach This book takes a step-by-step approach, is explained in a conversational and easy-to-follow style, and includes ample screenshots . Each topic is explained sequentially through planning, preparing, installing, configuring, and validating of all vRealize Automation's components.
Therapeutic Effects of the Pilates Method in Patients with Multiple Sclerosis: A Systematic Review

The Pilates Method is a rehabilitation tool with verified benefits in pain management, physical function, and quality of life in many different physiotherapy areas. It could be beneficial for patients with multiple sclerosis (pwMS). The aim of the study was to summarize current evidence for the effectiveness of Pilates in pwMS. A comprehensive search of Cinahl, Scopus, Web of Science, PEDro, and PubMed (including PubMed Central and Medline) was conducted to examine randomized controlled trials (RCT) that included Pilates intervention in multiple sclerosis. The PEDro scale and the Cochrane risk-of-bias tool, RoB-2, were used to evaluate risk of bias for RCT. Twenty RCT (999 patients) were included. Ten were of good quality (PEDro), and seven had low risk of bias (RoB-2). Pilates improves balance, gait, physical-functional conditions (muscular strength, core stability, aerobic capacity, and body composition), and cognitive functions. Fatigue, quality of life, and psychological function did not show clear improvement. There was good adherence to Pilates intervention (average adherence ≥ 80%). Cumulative data suggest that Pilates can be a rehabilitation tool for pwMS. High adherence and few adverse effects were reported. Future research is needed to develop clinical protocols that could maximize therapeutic effects of Pilates for pwMS.
Comparative Proteomics of the Acanthopagrus schlegelii Gonad in Different Sex Reversal

A substantial proportion of Acanthopagrus schlegelii individuals change sex from male to female during their lifetime. However, the mechanisms underlying sex change are unknown. In this research, iTRAQ analyses of proteins obtained from A. schlegelii gonads in four different stages of development were compared. In total, 4692 proteins were identified, including common sex-specific proteins, such as sperm-associated antigen 6 and cilia- and flagella-associated proteins in males, and zona pellucida sperm-binding proteins in females. Furthermore, proteins involved in the integrin signaling pathway, inflammation mediated by the chemokine and cytokine signaling pathways, pyruvate metabolism, CCKR signaling map, de novo purine biosynthesis and the ubiquitin proteasome pathway were upregulated in female gonads, whereas proteins implicated in DNA replication, the heterotrimeric G-protein signaling pathway, Gi alpha- and Gs alpha-mediated pathways, wnt signaling pathway, and hedgehog signaling pathway were upregulated in male gonads. Interestingly, cathepsins were only identified in ovaries, indicating their potential involvement in rapid ovarian development. Apoptosis-related proteins expressed in ovaries (such as MAPK and Cdc42) may protect them from cancer. This is the first report on the gonad proteome from A. schlegelii in different stages of sex reversal, and the results provide important fundamental data for studying the molecular mechanisms of sex reversal.
Structural dynamics and functional analysis of Saprolegnia parasitica chitin synthases 5 in a phospholipid bilayer

Abstract Saprolegnia parasitica is an oomycete responsible for a fish disease called saprolegniosis, which poses an economic and environmental burden on aquaculture production. In Saprolegnia, CHS5 of S. parasitica (SpCHS5) contains an N-terminal domain, a catalytic domain of the glycosyltransferase −2 family containing a GT-A fold, and a C-terminal transmembrane domain. No three-dimensional structure of SpCHS5 is reported yet disclosing the structural details of this protein. We have developed a structural model of full-length SpCHS5 and validated it by molecular dynamics simulation technique. From the 1 microsecond simulations, we retrieved the stable RoseTTAFold model SpCHS5 protein to explain characteristics and structural features. Furthermore, from the analysis of the movement of chitin in the protein cavity, we assumed that ARG 482, GLN 527, PHE 529, PHE 530, LEU 540, SER 541, TYR 544, ASN 634, THR 641, TYR 645, THR 641, ASN 772 residues as a main cavity lining site. In SMD analysis, we investigated the opening of the transmembrane cavity required for chitin translocation. The pulling of chitin from the internal cavity to the extracellular region was observed through steered molecular dynamics simulations. A comparison of the initial and final structures of chitin complex showed that there’s a transmembrane cavity opening in the simulations. Overall, this present work will help us understand the structural and functional basis of CHS5 and design inhibitors against SpCHS5. Communicated by Ramaswamy H. Sarma Conformational changes of chitin at the protein tunnel where ‘a’ is the orientation of chitin at 1000 ns, and ‘b’ is the initial orientation at 0 ns of the molecular dynamic simulation.
Decentralized Triple Proximal Splitting Algorithm With Uncoordinated Stepsizes for Nonsmooth Composite Optimization Problems

In this article, we consider a class of decentralized nonsmooth composite optimization problems over undirected graphs. The global optimization problem is to minimize the sum of local objective functions consisting of a Lipschitz-differentiable convex function and two possibly nonsmooth convex functions, one of which contains a bounded linear operator. The goal is to solve the global optimization problem through decentralized computation and communication over a network of agents without a central coordinator. Through using triple proximal splitting operators to deal with the nonsmooth terms, we come up with a novel decentralized algorithm with uncoordinated stepsizes, where the stepsizes with independent upper bounds are also distributed for agents or edges over the communication network. Furthermore, we establish the sublinear convergence rate for the proposed algorithm in terms of the first-order optimality residual in a nonergodic sense. Simulation experiments on a constrained quadratic programming problem and an optimal load-sharing problem are carried out to verify the correctness of the theoretical results.
Evaluation of (CNT@CIP)-Embedded Magneto-Resistive Sensor Based on Carbon Nanotube and Carbonyl Iron Powder Polymer Composites

The conductive polymeric composites incorporating carbon nanotube (CNT) and carbonyl iron powder (CIP) have attracted much attention for various sensor applications. In this paper, a comprehensive study of the magneto-sensing property of a CNT-CIP embedded polymer composite is conducted to implement the composite as magneto-sensors. Thus, this study experimentally investigated the magneto-sensing performances of CNT-doped polymeric composites with the addition of CIP in terms of electrical conductivity, sensitivity, repeatability, and response time. First, the CNT-CIP clusters were manufactured and their interactions were analyzed with the zeta potential measurement and SEM observation. Then, the CNT-CIP clusters were embedded into the polymeric composites for the magneto-sensing evaluations. Experiments showed that the CNT contents in the range of percolation threshold (i.e., 0.5% and 0.75%) are optimal values for sensor applications. The addition of CNT 0.5% and 0.75% resulted in a high sensitivity of 7% and a faster response time within 400 ms. Experiment evaluation confirmed a high potential of implementing CNT-CIP composite as magneto-sensors.
The Typology of Motion Expressions in English, Japanese, and Persian: Reconsidering the Cline versus Typology Debate Based on Heading

Talmy’s cognitive-semantic typology divides languages based on how path and manner of motion are generally encoded, but recently some studies have suggested that the original typology needs re-examining either by adding a new type (e.g., Slobin, 2004) or using a cline rather than a two or three-language division (e.g., Ibarretxe-Antouñano, 2009). Furthermore, Matsumoto (2003) has suggested that Talmy’s original typology should be founded on the heading of a language, rather than the original terms of satellite and verb. This study observes Persian motion events through this concept to help determine if an intermediate language can neatly fit into a single category when analyzed based on heading, or whether a new cline based on heading should be considered. We compared data from a translation corpus of the short story “A Christmas Carol” using a representative verb-framed and satellite-framed language (i.e., Japanese and English), and found that Persian shares some path encoding tendencies with both English and Japanese, but also has significant differences, which suggest it could perhaps be better described as fitting on a cline of path-salience, rather than simply placed in either category.
(5E,7E)-4,5,6 Trihydroxy-3-(hydroxymethyl)tetrahydro-2H-pyran-2-ylheptadeca-5,7-dienoate from Euclea crispa (L.) Inhibits Ovarian Cancer Cell Growth by Controlling Apoptotic and Metastatic Signaling Mechanisms

Bioactive compound (5E,7E)-4,5,6 trihydroxy-3-(hydroxymethyl)tetrahydro-2H-pyran-2-ylheptadeca-5,7-dienoate (compound 2) was isolated from Euclea crispa (E. crispa) by the chromatographic methods. Further, the compound was confirmed by spectroscopic techniques such as ultraviolet-visible (UV/Vis) spectrometer, Fourier transform infrared (FTIR) spectrometer, and 1H and 13C nuclear magnetic resonance (NMR). Compound 2 exhibited a significant antioxidant activity with IC50 values. It restrained the auxesis of HO-8910 cells in a shot-dependent mode. CXCR4, HER2, and Akt proteins involved in cell proliferation and metastasis were found to be significantly reduced (p < 0.05). The protein that is responsible for the death of cells (Bcl-2 and Bcl-xL) was reduced (p < 0.05), while the protein expression of p53 and caspase-9 was increased (p < 0.05) in compound 2-treated HO-8910 cells. The results of molecular docking analysis showed the binding affinity with CXCR4 and HER2. Thus, compound 2 can serve as a promising chemotherapeutic agent for the intervention of ovarian cancer. The findings of this study conclude that compound 2 from E. crispa might work as a potential antioxidative and chemotherapeutic agent. The in vivo studies and attempts will pave way for this compound to be an effective drug hereafter.
Association of Tandem Repeat Number Variabilities in Subunit S of the Type I Restriction-Modification System with Macrolide Resistance in Mycoplasma pneumoniae

Mycoplasma pneumoniae is one of the major pathogens responsible for pneumonia in children. Modern molecular genetics has advanced both the management and the epidemiologic study of this disease. Despite these advancements, macrolide resistance remains a global threat in the management of M. pneumoniae infection, for which the genetic background remains unrevealed. In this study, the result of whole genome analysis of 20 sequence type 3 (ST3) M. pneumoniae strains were examined to investigate the gene(s) associated with macrolide resistance. Overall, genetic similarities within M. pneumoniae, and especially ST3, were very high (over 99.99 %). Macrolide resistant ST3 strains shared 20 single nucleotide polymorphisms, of which one gene (mpn085) was found to be associated with resistance. BLAST comparison of M. pneumoniae revealed regular tandem repeat number variabilities between macrolide-susceptible and resistant strains for genes coding the Type I restriction-modification (R-M) system of subunit S (HsdS). Of the ten known HsdS genes, macrolide resistance was determined by the unique tandem repeat of mpn085 and mpn285. In conclusion, the use of whole genome sequencing (WGS) to target macrolide resistance in M. pneumoniae indicates that the determinant of macrolide resistance is variabilities in the tandem repeat numbers of the type I R-M system in subunit S.
Combination of Novel Therapies for HDV

Treatment options for HDV have been limited to interferon alfa-based therapies with its poor efficacy to side effects ratio. Several novel therapies have now advanced into the clinic. As they each have a different mechanism of action, there is the potential for combination therapy. Here we review how studying the HDV life cycle has led to the development of these novel therapies, the key developments leading to, and the details of, the first combination study of novel anti-HDV therapies, and suggest what additional combinations of novel therapies can be anticipated as we enter this exciting new area of HDV treatments.
CO2 and CH2 Adsorption on Copper-Decorated Graphene: Predictions from First Principle Calculations

Single-layer graphene decorated with monodisperse copper nanoparticles can support the size and mass-dependent catalysis of the selective electrochemical reduction of CO2 to ethylene (C2H4). In this study, various active adsorption sites of nanostructured Cu-decorated graphene have been calculated by using density functional theory to provide insight into its catalytic activity toward carbon dioxide electroreduction. Based on the results of our calculations, an enhanced adsorption of the CO2 molecule and CH2 counterpart placed atop of Cu-decorated graphene compared to adsorption at pristine Cu metal surfaces was predicted. This approach explains experimental observations for carbon-based catalysts that were found to be promising for the two-electron reduction reaction of CO2 to CO and, further, to ethylene. Active adsorption sites that lead to a better catalytic activity of Cu-decorated graphene, with respect to general copper catalysts, were identified. The atomic configuration of the most selective CO2 toward the reduction reaction nanostructured catalyst is suggested.
Simulation Tool and Online Demonstrator for CDMA-Based Ultrasonic Indoor Localization Systems

This work presents the CODEUS platform, which includes a simulation tool together with an online experimental demonstrator to offer analysis and testing flexibility for researchers and developers in Ultrasonic Indoor Positioning Systems (UIPSs). The simulation platform allows most common encoding techniques and sequences to be tested in a configurable UIPS. It models the signal modulation and processing, the ultrasonic transducers’ response, the beacon distribution, the channel propagation effects, the synchronism, and the application of different positioning algorithms. CODEUS provides results and performance analysis for different metrics and at different stages of the signal processing. The UIPS simulation tool is specified by means of the MATLAB© App-Designer environment, which enables the definition of a user-friendly interface. It has also been linked to an online demonstrator that can be managed remotely by means of a website, thus avoiding any hardware requirement or equipment on behalf of researchers. This demonstrator allows the selected transmission schemes, modulation or encoding techniques to be validated in a real UIPS, therefore enabling a fast and easy way of carrying out experimental tests in a laboratory environment, while avoiding the time-consuming tasks related to electronic design and prototyping in the UIPS field. Both simulator and online demonstrator are freely available for researchers and students through the corresponding website.
Compact Modeling of Multi-Gate Transistors

Scaling of the classical planar MOSFET below 20 nm gate length is facing not only technological difficulties but also limitations imposed by short channel effects, gate and junction leakage current due to quantum tunneling, high body doping induced threshold voltage variation, and carrier mobility degradation. Non-classical multiple-gate structures such as double-gate (DG) FinFETs and surrounding gate field-effect-transistors (SGFETs) have good electrostatic integrity and are an alternative to planar MOSFETs for below 20 nm technology nodes. Circuit design with these devices need compact models for SPICE simulation. In this work physics based compact models for the common-gate symmetric DG-FinFET, independent-gate asymmetric DG-FinFET, and SGFET are developed. Despite the complex device structure and boundary conditions for the Poisson-Boltzmann equation, the core structure of the DG-FinFET and SGFET models, are maintained similar to the surface potential based compact models for planar MOSFETs such as SP and PSP. TCAD simulations show differences between the transient behavior and the capacitance-voltage characteristics of bulk and SOI FinFETs if the gate-voltage swing includes the accumulation region. This effect can be captured by a compact model of FinFETs only if it includes the contribution of both types of carriers in the Poisson-Boltzmann equation. An accurate implicit input voltage equation valid in all regions of operation is proposed for common-gate symmetric DG-FinFETs with intrinsic or lightly doped bodies. A closed-form algorithm is developed for solving the new input voltage equation including ambipolar effects. The algorithm is verified for both the surface potential and its derivatives and includes a previously published analytical approximation for surface potential as a special case when ambipolar effects can be neglected. The symmetric linearization method for common-gate symmetric DG-FinFETs is developed in a form free of the charge-sheet approximation present in
Lung Fibroblasts from Idiopathic Pulmonary Fibrosis Patients Harbor Short and Unstable Telomeres Leading to Chromosomal Instability

Idiopathic pulmonary fibrosis (IPF) is associated with several hallmarks of aging including telomere shortening, which can result from germline mutations in telomere related genes (TRGs). Here, we assessed the length and stability of telomeres as well as the integrity of chromosomes in primary lung fibroblasts from 13 IPF patients (including seven patients with pathogenic variants in TRGs) and seven controls. Automatized high-throughput detection of telomeric FISH signals highlighted lower signal intensity in lung fibroblasts from IPF patients, suggesting a telomere length defect in these cells. The increased detection of telomere loss and terminal deletion in IPF cells, particularly in TRG-mutated cells (IPF-TRG), supports the notion that these cells have unstable telomeres. Furthermore, fibroblasts from IPF patients with TRGs mutations exhibited dicentric chromosomes and anaphase bridges. Collectively, our study indicates that fibroblasts from IPF patients exhibit telomere and chromosome instability that likely contribute to the physiopathology.
A Strategic Evaluation of Energy-Consumption and Total Execution Time for Cloud Computing Environment

Cloud computing is a very budding area in the research field and as well as in the IT enterprises. Cloud Computing is basically on-demand network access to a collection of physical resources which can be provisioned according to the need of cloud user under the supervision of Cloud Service provider interaction. In this era of rapid usage of Internet all over the world, Cloud computing has become the center of Internet-oriented business place. For enterprises, cloud computing is the worthy of consideration and they try to build business systems with minimal costs, higher profits and more choice; for large-scale industry, energy consumption and total execution tome are the two important aspects of cloud computing. In the current scenario, IT Enterprises are trying to minimize the energy-consumption which, in turn, maximizes the profit of the industry. And they are also trying to reduce total execution time which, in turn, is concerned with providing better Quality of Service (QoS). Therefore, in this paper we have made an attempt to evaluate energy- consumption and total execution time using CloudSim simulator which helps to make evaluation performance of energy consumption and total execution time of user application.