Miracle-dz/UniFAR-FTUs huggingface dataset:
The function of Copine 6 in the brain

The formation of new or the remodeling of pre-existing synapses is thought to provide the cellular correlate of learning and memory processes. In the mammalian forebrain, the postsynaptic site of most excitatory synapses is located on dendritic spines. Even after their formation, dendritic spines remain plastic and undergo experience-dependent remodeling that correlates with adaptations in the synaptic strength. Hereby, changes in neuronal activity have to be translated into long- and short-term modifications of dendritic spines. Here, we identify Copine 6 as a novel activity sensor critically involved in these processes. This project started with an initial characterization of Copine 6 in vitro. A shRNA-mediated knockdown of Copine 6 in primary hippocampal culture increases the number of dendritic spines and influences their maintenance upon changes in neuronal activity. The cytosolic Copine 6 is recruited into postsynaptic sites upon NMDA receptor activation. This translocation of Copine 6 upon increase in the intracellular calcium concentration influences the localization of its binding partner, the actin cytoskeleton modulator Rac1. We demonstrate that presence of Copine 6 affects not only the localization but also the activation state of Rac1. These data indicate that in vitro Copine 6 translates activity-induced calcium signals into morphological changes of the postsynapse through translocation and promotion of Rac1 activity in activated spines. By the generation of mice deficient for Copine 6 we aimed to identify the role of Copine 6 in vivo. We found that Copine 6 expression is strongest in the hippocampus and starts postnatally when synapses are formed. In the hippocampus, Copine 6 expression is restricted to excitatory neurons. In line with its expression pattern, Copine 6 is dispensable for development. Copine 6 knockout mice thrive indistinguishable from their littermate controls and do not show an overt phenotype. In the hippocampus of adult Copine 6 knockout mice the spine density and morphology, and overall synaptic function is not changed, consistent with an unaffected Rac1 signaling. In contrast, loss of Copine 6 in vivo strongly affects synaptic plasticity. Copine 6 knockout mice are deficient in hippocampal long-term potentiation, suggesting that Copine 6 is dispensable for spine formation but essential for synaptic plasticity. In a yeast-two hybrid screen we identified SIMPL as a novel Copine 6 interacting partner. We provide evidence that presence of Copine 6 anchors the NF-kappaB co-activator SIMPL in the cytoplasm and prevents its translocation into the nucleus. In consequence, absence of Copine 6 increases the transcriptional activity of NF-kappaB. These data indicate that Copine 6 may regulate long-term adaptations in neuronal functions that involve transcriptional regulations. Taken together, this thesis identifies Copine 6 as an important player in the regulation of synaptic plasticity in vitro and in vivo.
Effect of herbicides and nutrient management on weed flora, nutrient uptake and yield of wheat (Triticum aestivum) under irrigated conditions.

Isoproturon, clodinafop and sulfosulfuron alone at 750, 60 and 30 g/ha, respectively, and tank mixture of isoproturon at 500 g/ha + 2, 4-D at 500 g/ha, isoproturon at 500 g/ha + clodinafop at 30 g/ha and isoproturon at 500 g/ha + sulfosulfuron at 15 g/ha were evaluated against mixed weed flora in wheat. All the herbicide treatments significantly reduced the dry weight of complex weeds, although they differed in their effect on weed species. While sulfosulfuron and clodinafop alone and as a tank mixture with isoproturon effectively controlled grassy weeds than all other herbicide treatments, the tank mix application of isoproturon at 500 g/ha + 2, 4-D at 500 g/ha and isoproturon at 500 g/ha + sulfosulfuron at 15 g/ha were equally effective against broadleaf weeds. The broadleaf weeds being dominant in the experimental field, the overall weed density and dry matter production at different stages of crop growth were minimized by isoproturon at 500 g/ha+sulfosulfuron at 15 g/ha and isoproturon at 500 g/ha+2, 4-D at 500 g/ha. Uninterrupted weed growth depleted 20.97 kg N, 3.13 kg P and 26.94 kg K/ha, while it was lowest with isoproturon at 500 g/ha + sulfosulfuron at 15 g/ha. Maximum uptake of N (150.20 kg/ha), P (41.00 kg/ha) and K (194.14 kg/ha) by wheat crop was in plots treated with tank mixture of isoproturon at 500 g/ha + sulfosulfuron at 15 g/ha, while in weedy check plots N, P and K uptake by crop was 87.87, 23.82 and 118.04 kg/ha, respectively. Uncontrolled weeds in weedy check plots reduced wheat yield by 31.4% as compared to herbicide treated plots. Highest grain yield obtained with isoproturon at 500 g/ha + sulfosulfuron at 15 g/ha (58 q/ha) followed by isoproturon at 500 g/ha + 2, 4-D at 500 g/ha (55.34 q/ha) was significantly higher than all other treatments. Among nutrient management treatments, application of 75% RDF+vermicompost at 1.5 t/ha and 50% RDF + vermicompost at 3.0 t/ha resulted in significant increase in weed dry matter, NPK uptake, chlorophyll and protein content and grain and straw yield over RDF alone.
Improving Employee Satisfaction Through Organization Support

This study aims to identify and analyze the effect of health protection benefits, recreation leave, and flexible working hours on job satisfaction in employees of PT. Pos Indonesia, South Jakarta branch. Retrieval of data is done through the deployment of a questionnaire to 109 employees PT. Pos Indonesia branch of South Jakarta with scale Likert 1-5 was then analyzed by SEM (Structural Equation Modeling). Research shows that only two hypotheses in this study were accepted, namely, there is an influence between recreation leave and flexible working hours on job satisfaction. Keywords—benefit health protection, flexible working hour, job satisfaction, recreation leave
Incessant ovulation--a factor in ovarian neoplasia? [letter]

Focus is on some evidence of a possible relationship between the repeated involvement of the ovarian surface epithelium in the process of ovulation and the frequency of the development of the common ovarian neoplasms from this epithelium. Data about comparative ovarian oncology have been accumulating and 3 noteworthy features have been revealed: 1) practically all tumor types encountered in the human ovary may be seen in the mammalian ovary; 2) ovarian tumors in other mammals are apparently much rarer than in human beings; and 3) this rarity is largely because of the infrequency of epithelial neoplasms derived from the ovarian surface epithelium--the cystadenoma and the adenocarcinoma. In women these account for the majority of all ovarian neoplasms and for the great majority of ovarian malignant neoplasms. Another situation has been revealed in the domestic fowl with its frequent egg production. Adenocarcinoma of the ovary is the most common epithelial neoplasm in the entire body. The relation to egg production was demonstrated in an experiment where adenocarcinomas were induced in the ovaries of 17 out of 19 hens by maintaining them throughout life in a stable environment with 12 hours of fluorescent lighting daily. Egg production rapidly reached a maximum; it then declined over 3 years with no seasonal rest periods. No tumors appeared in control hens kept under normal lighting conditions with seasonal variations. The surface epithelium of the ovary does not appear to play any active role in the adult processes of reproduction. The few electron microscopic studies available suggest a simple mesothelial function. The process of ovulation involves repeated minor trauma to the covering epithelium as well as repeated exposure of the ovarian surface to the estrogen rich viscous follicular fluid. Epidemiological data in human beings may be suggestive of a possible relationship between the process of ovulation and the development of the common ovarian neoplasm. In the absence of ovulation ovarian neoplasms of surface epithelial origin are very rare but germ cell and mesenchymal tumors occasionally arise. In patients denied the ovarian physiological rest periods afforded by pregnancies a higher incidence of ovarian cancer has been reported. The hypothesis that the extravagant and mostly purposeless ovulations in the human female may have a contributing role in neoplasia of the surface epithelium of the ovary requires additional consideration.
Alternative splicing of the human constitutive androstane receptor gene creates receptors with unique function and ligand specificity

The human constitutive androstane receptor (CAR) regulates the expression of genes involved in xenobiotic metabolism in the liver. The CAR gene utilizes multiple alternative splicing events during pre-mRNA processing, thereby increasing the CAR transcriptome. The work presented in this dissertation focuses on the functional analysis of a prominent human CAR variant, CAR2 that possesses a 4amino acid insertion in the ligand binding domain. Previous investigations led us to hypothesize that the CAR2 variant is a ligand-activated receptor and possesses a unique ligand binding profile giving rise to novel biological function. We now demonstrate that CAR2 constitutes approximately one-third and one-half of the total CAR transcriptome in human hepatocytes and small intestine, respectively. Further, we identify the common plasticizers, di(2-ethylhexyl) phthalate (DEHP) and di-isononyl phthalate (DiNP) as highly potent and uniquely selective agonists of CAR2. Results from reporter transactivation assays reveal that DEHP and DiNP activate CAR2 at low nanomolar concentrations. In addition, comparative genomic analysis show that the typical mouse, rat and marmoset models of toxicity can not accurately profile potential human toxicity due to these species inability to generate a CAR2-like transcript. It is also demonstrated that CAR2 possesses an altered ligand pocket that allows for the highly potent and specific activation of the variant by DEHP and DiNP. Further studies show that CAR1 and CAR3 share similar ligand activation profiles; whereas CAR2 responds to most CAR1 and CAR3 ligands as well as a unique subset of chemicals. Finally, it is now shown that meclizine, a human CAR1 inverse-agonist, is a specific agonist of CAR2. A meclizine derived pharmacophore was utilized in a ligand-based virtual screening and identified two novel CAR2 agonists from the NCI chemical database. The results of this dissertation will aid in the development of better models of human CAR activation, give a more complete understanding of the interaction of CAR with xenobiotics, yield novel insight into potential mechanisms of phthalate toxicity and provide the foundation for future studies into the physiologic functions of alternatively spliced variants of CAR.
Non-Line of Sight LoRa –Based Localization using RSSI-Kalman-Filter and Trilateration

The method that analyzes in this research is the combination of the Received Signal Strength Indicator (RSSI) with the Trilateration Method. This research also filtered the RSSI value using the Kalman filter method for smoothing data. The localization system traditionally based on Global Positioning System (GPS) device. However, GPS technology not working well in Non-line-of-sight (NLOS) like an indoor location or mountain area. The other way to implement the localization system is by using LoRa technology. This technology used radio frequency to communicate with each other node. The radiofrequency has a measurement value in the form of signal strength. These parameters, when combined with the trilateration method, can be used as a localization system. After implementation and testing, the system can work well compared with the GPS system for localization. RMSE is used to calculate error distance on these methods, the result from three methods used, the value from RSSI with Kalman filter have a close result to actual position, then value GPS follows with close result from Kalman filter, and the last one is RSSI without Kalman filter.
ARTIFICIAL INTELLIGENCE IN HELPING AUDITORS TO EVALUATE CLIENT FINANCIAL VIABILITY

Continuitatea activităţii este wml din principiile generale de care trebuie să se lină cont la formularea opiniei de audit. Ca parte a procesului de audit, auditorul trebuie să exprime opinia privind capacitatea întreprinderii de a continua activitatea sa într-un viitor previzibil. Tradiţional, conform prevederilor standardelor internaţionale de audit, opinia auditorului este bază pe un sistem prestabilit de indicatori financiari şi operativi, care, în esenţa au menirea unui barometru al viabilităţii financiare viitoare a agentului economic. In funcţie de dimensiunile acestor indicatori agentul economic poate f i atribuit unei din categoriile: financiar stabil sau instabil, sentinţă de care în mare măsură depinde capacitatea agentului economic de a-şi continua aciditatea şi de a păstra relaţiile cu creditorii, investitorii şi clienţii în viitor.
A Comparative Study of Bird Populations in Illinois, 1906-1909 and 1956-1958

On August 29, 1906, Alfred O. Gross and Howard A. Ray, working for the Illinois State Laboratory of Natural History (a parent organization of the Illinois Natural History Survey) under the direction of Stephen A. Forbes, began a series of statewide, cross-country censuses of birds in Illinois. These censuses were continued at intervals until September, 1909, and the data collected were published in a series of papers (Forbes 1907, 1908, 1913; Forbes & Gross 1921, 1922, 1923) that provided a quantitative record of the Illinois bird populations of that period and a potential basis for evaluating the adjustment of bird populations to a changing environment. In 1956—1958, we conducted statewide censuses similar to those of the 1906-1909 survey. In this paper we present an analysis of our field data and compare these data with those from the first survey.
Effect of Propolis Used in the Broiler Feed Mixtures to the Selected Quality Indicators of Cooked Ham

Propolis has many components that possess antibacterial and antioxidant properties. The aim of the study was to evaluate the effect of propolis as a dietary supplement added to feed mixture for broilers on oxidation stability, microbial and sensory quality of cooked ham. The one day old chickens were divided into four groups. The chickens of first, second and third group were fed by commercial feed mixtures HYD 01 and HYD 02 with propolis extract addition in amount 200, 300 respectively 400 mg/kg. The chicken cooked hams were prepared only with mixture of sodium nitrite and sodium chloride. The counts of total lactic acid bacteria, coliform bacteria and counts of enterococci were evaluated during 42 days of storage. Also the oxidative stability of hams was evaluated during 42 days storage. The count of total lactic acid bacteria, coliform bacteria and count of enterococci was not detected during the whole period of storage. It was found higher oxidative stability of experimental cooked hams in compare to control group until 35 days of storage. Propolis extract as a dietary supplement in feed mixtures for broilers had no negative sensory effect in ready-to-eat meat product–cooked ham.
ReUse: A Recommendation System for Implementing User Stories

— In agile software development, user stories contain feature descriptions that are used as the entry points of discussions about the design, specification, requirements, and estimation of the software features. The first step in implementing a user story is to find proper files in the code base to make changes. To help the developers, in this paper, we describe a new approach that automatically recommends the files where a feature will most likely be implemented based on a given user story that describes the feature.
Spatial Pattern of Weeds Based on Multispecies Infestation Maps Created by Imagery

Weeds are often spatially aggregated in maize fields, and the level of aggregation varies across and within fields. Several annual weed species are present in maize fields before postemergence herbicide application, and herbicides applied will control several species at a time. The goal of this study was to assess the spatial distribution of multispecies weed infestation in maize fields. Ground-based imagery was used to map weed infestations in rain-fed maize fields. Image segmentation was used to extract weed cover information from geocoded images, and an expert-based threshold of 0.102% weed cover was used to generate maps of weed presence/absence. From 19 site-years, 13 (68%) demonstrated a random spatial distribution, whereas six site-years demonstrated an aggregated spatial pattern of either monocotyledons, dicotyledons, or both groups. The results of this study indicated that monocotyledonous and dicotyledonous weed groups were not spatially segregated, but discriminating these weed groups slightly increased the chances of detecting an aggregated pattern. It was concluded that weeds were not always spatially aggregated in maize fields. These findings emphasize the need for techniques allowing the assessment of weed aggregation prior to conducting site-specific weed management. Nomenclature: Bird vetch, Vicia cracca L. VICCR; broadleaf plantain, Plantago major L. PLAMA; common lambsquarters, Chenopodium album L. CHEAL; common ragweed, Ambrosia artemisiifolia L. AMBEL; dandelion, Taraxacum officinale G. H. Weber ex Wiggers TAROF; ladysthumb, Polygonum persicaria L. POLPE; oakleaf goosefoot, Chenopodium glacum L. CHEGL; oxeye daisy, Chrysanthemum leucanthemun L. CHYLE; redroot pigweed, Amaranthus retroflexus L. AMARE; rhombic copperleaf, Acalypha rhomboidea Raf. ACCRH; shepherd's purse, Capsella bursa-pastoris (L.) Medik. CAPBP; white clover, Trifolium repens L. TRFRE.
Validating the S-STEM among Malaysian Pre-University Students

The purpose of this study is to validate the measure of student attitudes toward science, technology, engineering, and mathematics (S-STEM). This study used the cross-sectional design to employ translation and cultural adaptation as well as providing evidence of the reliability and validity of the S-STEM. The instrument was administered to 748 pre-university students in Penang, Malaysia. Data were analyzed using confirmatory factor analysis (CFA) with AMOS 19.0. Results support S-STEM as a three-factor multidimensional construct, namely attitude towards science, attitude towards technology/engineering, and attitude towards mathematics. All statistics such as factor loadings, average variance explained, construct reliability, evidence of discriminant validity, and goodnessof-fit indices were found to be at acceptable values. These positive results are significant because although the instrument has undergone numerous modifications, such as translation and others, the generalizability of the instrument is still preserved in pre-university Malaysian students. Counselors may administer the instrument to facilitate the choice of courses to enroll at university. The research may utilize the instrument to gather data in providing measures to improve students’ participation in learning STEM. The practical implications, as well as the methodological limitations of the present study, are discussed.
HYBRID GFRP-CONCRETE BOX GIRDER FABRICATED AND TESTED IN FLEXURE

Pultruded trapezoidal sheet pile sections fabricated using glass-fiber reinforced polymer (GFRP) and integrated with a flat GFRP plate and thin concrete slab have been used to develop a new box girder. Adhesive bond and shear stud systems were explored to connect the two components. The 3300 mm long simply supported girders were tested in positive and negative bending. A short length of the box GFRP section was filled with concrete to form a rigid diaphragm over the supports. It was shown that adding shear studs to the adhesive did not further enhance flexural stiffness but increased flexural strength by 51%, relative to adhesive bonding only. The concrete slab was designed to be efficiently in compression and has contributed 87% and 112%, respectively, to flexural strength and stiffness of the girder, relative to the GFRP box girder alone.
Maritime surveillance image enhancement: a comparison and improvement of dehazing techniques

 Abstract —The dehazing problem where different atmospheric particles brings certain amount of noise to images is very important in outdoor video surveillance systems. This paper compares the most significant single image dehazing approaches, proposes additional enhancement step in dehazing algorithms, and presents test results on maritime surveillance images that represents one group of long-range images.
E-recruitment: A Social Media Perspective

Electronic recruitment (E-recruitment) has become a common phenomenon due to the increasing utilization of information technology by the human resource departments in many organizations around the world. However, recently, we can also observe the integration of social media as a part of e-recruitment although the practice is limited. This review paper aims at discussing the role of social media on e-recruitment process based on existing literature. Most of the previous studies indicate that social media is not being used as the main source of e-recruitment, rather as one of the secondary sources. Further, it has been revealed that such utilization of social media as complementary source is getting popular due to the inexpensive availability of information. The paper is expected to be beneficial for the scholars as a substantial literature evidence for reference as well as for human resource professionals for some practical guidelines (based on recommendations provided) regarding the utilization of social media information for e-recruitment.
Identification of prognostic genes in patients with colorectal liver metastasis -- through survival and random forests analysis on microarray data

OF THE THESIS Identification of Prognostic Genes in Patients with Colorectal Liver Metastasis – Through Survival and Random Forests Analysis on Microarray Data by Jo Chung Master of Science in Statistics with a Concentration in Biostatistics San Diego State University, 2012 DNA microarray technologies provide an opportunity to examine thousands of genes, identify molecular biomarkers of diseases and predict patient response to treatment. In this study, we analyzed the gene expression profiles of 24 patients with colorectal liver metastasis (CLM) who underwent metastatic liver resection. The association between gene expression level and survival outcome was evaluated using Cox proportional hazards regression. Random Forests and risk scores were used to construct a survival classifier based on 14 prognostic genes, which were closely associated with patient survival. According to leaveone-out cross validation, all 24 patients were correctly assigned into high-risk or low-risk groups (p<0.001, log-rank test). This 14-gene signature was also examined in an independent cohort of 30 patients with primary colorectal cancer. Our results support further investigation of molecular biomarkers, which can be used to estimate prognosis in colorectal liver metastasis, as well as to individualize therapeutic decisions for patients.