Miracle-dz/UniFAR-FTUs huggingface dataset:
Multi-Operator Minimum Variance Adaptive Beamforming Algorithms Accelerated With GPU

The goal of this work is to design high-resolution, high-contrast and robust MV adaptive beamforming algorithms, which are also implemented in real-time frame rate. Multi-operator optimization is introduced into MV adaptive beamforming in this work to propose a multi-operator MV adaptive beamforming algorithmic optimization framework. Based on the proposed algorithmic optimization framework, the algorithm optimization can be either conducted by activating a single optimization operator, or conducted by activating multiple optimization operators. The multi-operator MV (MOMV) adaptive beamforming algorithms are then derived from this framework. Moreover, in order to promote the real-time imaging capability of MOMV beamforming, a GPU-based parallel acceleration framework is proposed along with the algorithmic optimization framework by exploring the image-level coarse-grained parallelization and pixel-level fine-grained parallelization. GPU computing resource allocation strategy and memory access strategy are both explored to better design the acceleration framework. Comprehensive quantitative simulation evaluations and qualitative in vivo experiments of imaging performance are studied, and the results demonstrate that the proposed MOMV adaptive beamforming algorithms significantly improve the imaging performance as compared with other MV beamforming algorithms, which have high resolution, high contrast, good robustness, and real-time imaging capability with thousands of acceleration speedup. Furthermore, the MOMV beamforming algorithm without eigen-decomposition and projection optimization operator achieves much higher beamforming frame rate with little downgrade of image quality as compared with the MOMV beamforming algorithm with all optimization operators.
Bone Morphogenetic Protein-2 Signaling in the Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells Induced by Pulsed Electromagnetic Fields

Pulsed electromagnetic fields (PEMFs) are clinically used with beneficial effects in the treatment of bone fracture healing. This is due to PEMF ability to favor the osteogenic differentiation of mesenchymal stem cells (MSCs). Previous studies suggest that PEMFs enhance the osteogenic activity of bone morphogenetic protein-2 (BMP2) which is used in various therapeutic interventions. This study investigated the molecular events associated to the synergistic activity of PEMFs and BMP2 on osteogenic differentiation. To this aim, human MSCs (hMSCs) were exposed to PEMFs (75 Hz, 1.5 mT) in combination with BMP2, upon detection of the minimal dose able to induce differentiation. Changes in the expression of BMP signaling pathway genes including receptors and ligands, as well as in the phosphorylation of BMP downstream signaling proteins, such as SMAD1/5/8 and MAPK, were analyzed. Results showed the synergistic activity of PEMFs and BMP2 on osteogenic differentiation transcription factors and markers. The PEMF effects were associated to the increase in BMP2, BMP6, and BMP type I receptor gene expression, as well as SMAD1/5/8 and p38 MAPK activation. These results increase knowledge concerning the molecular events involved in PEMF stimulation showing that PEMFs favor hMSCs osteogenic differentiation by the modulation of BMP signaling components.
Legal education without the law – lay clients as teachers and assessors in communication skills

Abstract This paper reports an empirical study of the use of simulated clients to assess (facilitate the learning of) interviewing skills and communicative competence of law students at the University of Hong Kong (HKU) from February 2013 to April 2014. In this period, about 400 HKU Postgraduate Certificate in Laws students participated in interviewing exercises with simulated clients, who are lay persons trained to portray clients in a realistic manner and to assess communicative competence by standardized rubrics designed in Scotland since 2006. HKU Faculty of Law is the first law school in Asia to adopt this standardized client program to assess law students’ interviewing skills. The paper will present the data analysis of assessment results of the students and their evaluation of this experiential learning program. Our analysis confirms the reliability and validity of using standardized clients as assessors of interviewing skills. It also reveals the necessity of modification of the original design of standardized client program, particularly in relation to the assessment aspect of it, according to specific cultural and commercial needs in an Asian business city like Hong Kong.
Fat Grafting Improves Fibrosis and Scarring in Vulvar Lichen Sclerosus: Results From a Prospective Cohort Study

Objective The aim of the study was to evaluate the effect of lipotransfer in women presenting with fibrosis and scarring due to lichen sclerosus. Materials and Methods This prospective cohort study included 33 women attending the vulvar clinic of a public hospital. Patients received one lipotransfer treatment. Validated measures were used prospectively to assess the sexual function (Female Sexual Function Index, Female Sexual Distress Scale); symptoms (visual analog scale for itching, burning, soreness), pain (Pain Anxiety Symptoms Scale 20); psychological status and quality of life (Hospital Anxiety and Depression Scale, Relationship Assessment Scale, Wound Management Questionnaire Revised); physician-based disease signs (Vulvar Architecture Severity Scale). Data were analyzed using paired t test with nonparametric Wilcoxon matched-pairs signed rank test and unpaired t test with nonparametric Mann-Whitney test (Prism6 Software). Results The mean (SD) follow-up was 12.9 (3.5) months. Sexual function improved after treatment (p < .001), as well as the distress associated with sexuality (p < .0001). A significant improvement was reported in itching (p < .001), burning (p < .05), soreness (p < .001), and pain (p < .0001). Patients reported a significant improvement in romantic relationship (p < .05), anxiety (p < .0001), and depression (p < .0001). Improvement was not significant in the self-care associated with self-disgust assessment (p = .42). The clinical physician-based score showed an overall improvement in all the treated areas to lesser or greater extent. Conclusions The use of fat grafting in lichen sclerosus is promising. Further studies are required to rule out a potential placebo effect and to better understand the underlying molecular mechanism of action.
Covid-19: Highest risk patients are asked to stay at home for 12 weeks

A million and a half people in England who are at very high risk of severe illness and admission to hospital because of covid-12 will receive a letter this week asking them to stay at home for at least 12 weeks. Other people in the household will not have to remain inside but should adhere to Public Health England’s advice to leave a distance of at least 2 m when interacting with other people. People falling into this extremely vulnerable group include those who have undergone an organ transplantation, those having certain treatments for cancer, those with certain respiratory conditions, and pregnant women with significant heart disease (box 1). 1 They have been identified through general practice records, clinical reference groups, hospital trusts, and medical royal colleges. Box 1 ### Who should stay at home Among the groups of vulnerable people the government is saying should stay at home for 12 weeks are:RETURN TO TEXT
Psychometric Validation of the Danish Version of the Oswestry Disability Index in Patients with Chronic Low Back Pain.

STUDY DESIGN Registry based repeated-measures psychometric validation of the Danish Oswestry Disability Index (ODI) OBJECTIVE. : The goal was to use classical and modern psychometric validation methods to assess the measurement properties and the minimally clinical important difference (MCID) of the ODI in a Danish cohort of patients with chronic low back pain (LBP) being treated with spinal surgery. SUMMARY OF BACKGROUND DATA Scores for the ODI, EQ-5D, SF-36, leg pain, back pain, and a general rating of pain item from 800 patients with chronic LBP were extracted from the National Danish Spine Registry (DaneSpine) at baseline and 1-year post spine surgery. METHODS Confirmatory factor analysis (CFA) and item response theory (IRT) models were used to assess the psychometric properties of the ODI. MCID was also calculated based on generic legacy PROMs (EQ-5D and SF-36) and follow up pain scores. RESULTS While ODI did not fit a Rasch model, adequate fit to a CFA and a 2-parameter IRT model was found when accounting for differential item functioning (DIF) across diagnostic subgroups (degenerative spondylolisthesis, spondylosis, spinal stenosis, and herniated intervertebral disc). In addition, each group exhibited substantially different MCID values. CONCLUSION The Danish version of the ODI is valid and responsive, but only within each of the four major diagnosis subgroups: degenerative spondylolisthesis, spondylosis, spinal stenosis, and herniated intervertebral disc.Level of Evidence - 2.
The role of interfacial H-bonding on the electrical properties of UV-cured resin filled with hydroxylated Al2O3 nanoparticles

Surface hydroxylation of crude Al2O3 (c-Al2O3) nanoparticles by H2O2 was conducted to tailor the electrical properties of UV-cured resin. The hydroxyl groups on Al2O3 particles were designed to establish hydrogen bonding between the hydroxyl and carboxyl groups, which favors the enhancement of interfacial strength between fillers and UV-cured resin matrix. The effect of interfacial strength on the electrical properties was investigated. Owing to the improved interfacial strength, it can be conjectured that a larger volume of the interaction zone exists in UV-cured resin/hydroxylated Al2O3 (UV/h-Al2O3) composites. As a consequence, the number of deeper traps is increased, restraining the charge migration and raising the charge injection barrier. Thus, UV/h-Al2O3 composites exhibit remarkably enhanced breakdown strength, improved volume resistivity and suppressed space charge accumulation in comparison with that of UV/c-Al2O3 composites at the same filler content. It was found that the addition of 0.5 wt% h-Al2O3 increases the AC breakdown strength and volume resistivity by 15.5% and 367.9%, respectively. Our results suggest that hydroxylation is an efficient way to improve the electrical properties of UV-cured resin nanocomposites, thus promoting stereolithography 3D printing in the application of electrical and electronic fields.
First Complete Genome of Lake Sinai Virus Lineage 3 and Genetic Diversity of Lake Sinai Virus Strains From Honey Bees and Bumble Bees

Abstract The complete genome of Lake Sinai virus 3 (LSV3) was sequenced by the Ion Torrent next-generation sequencing (NGS) technology from an archive sample of honey bees collected in 2010. This strain M92/2010 is the first complete genome sequence of LSV lineage 3. From October 2016 to December 2017, 56 honey bee samples from 32 different locations and 41 bumble bee samples from five different locations were collected. These samples were tested using a specific reverse transcriptase-polymerase chain reaction (RT-PCR) method; 75.92% of honey bee samples and 17.07% of bumble bee samples were LSV-positive with the RT-PCR method. Phylogenetic comparison of 557-base pair-long RNA-dependent RNA polymerase (RdRp) genome region of selected 23 positive samples of honey bees and three positive bumble bee samples identified three different LSV lineages: LSV1, LSV2, and LSV3. The LSV3 lineage was confirmed for the first time in Slovenia in 2010, and the same strain was later detected in several locations within the country. The LSV strains detected in bumble bees are from 98.6 to 99.4% identical to LSV strains detected among honey bees in the same territory.
Telacebec for Ultrashort Treatment of Buruli Ulcer in a Mouse Model

Telacebec (Q203) is a new antitubercular drug with extremely potent activity against Mycobacterium ulcerans. Here, we explored the treatment-shortening potential of Q203 alone or in combination with rifampin (RIF) in a mouse footpad infection model. The first study compared Q203 at 5 and 10 mg/kg doses alone and with rifampin. Q203 alone rendered most mouse footpads culture negative in 2 weeks. Combining Q203 with rifampin resulted in a relapse-free cure 24 weeks after completing 2 weeks of treatment, compared to a 25% relapse rate in mice receiving RIF with clarithromycin, the current standard of care, for 4 weeks. ABSTRACT Telacebec (Q203) is a new antitubercular drug with extremely potent activity against Mycobacterium ulcerans. Here, we explored the treatment-shortening potential of Q203 alone or in combination with rifampin (RIF) in a mouse footpad infection model. The first study compared Q203 at 5 and 10 mg/kg doses alone and with rifampin. Q203 alone rendered most mouse footpads culture negative in 2 weeks. Combining Q203 with rifampin resulted in a relapse-free cure 24 weeks after completing 2 weeks of treatment, compared to a 25% relapse rate in mice receiving RIF with clarithromycin, the current standard of care, for 4 weeks. The second study explored the dose-ranging activity of Q203 alone and with RIF, including the extended activity of Q203 after treatment discontinuation. The bactericidal activity of Q203 persisted for ≥ 4 weeks beyond the last dose. All mice receiving just 1 week of Q203 at 2 to 10 mg/kg were culture negative 4 weeks after stopping treatment. Mice receiving 2 weeks of Q203 at 0.5, 2, and 10 mg/kg were culture negative 4 weeks after treatment. RIF did not increase the efficacy of Q203. A pharmacokinetics substudy revealed that Q203 doses of 2 to 10 mg/kg in mice produce plasma concentrations similar to those produced by 100 to 300 mg doses in humans, with no adverse effect of RIF on Q203 concentrations. These results indicate the extraordinary potential of Q203 to reduce the duration of treatment necessary for a cure to ≤ 1 week (or 5 doses of 2 to 10 mg/kg) in our mouse footpad infection model and warrant further evaluation of Q203 in clinical trials.
Effects of Independent and Combined Water-Deficit and High-Nitrogen Treatments on Flag Leaf Proteomes during Wheat Grain Development

We present the first comprehensive proteome analysis of wheat flag leaves under water-deficit, high-nitrogen (N) fertilization, and combined treatments during grain development in the field. Physiological and agronomic trait analyses showed that leaf relative water content, total chlorophyll content, photosynthetic efficiency, and grain weight and yield were significantly reduced under water-deficit conditions, but dramatically enhanced under high-N fertilization and moderately promoted under the combined treatment. Two-dimensional electrophoresis detected 72 differentially accumulated protein (DAP) spots representing 65 unique proteins, primarily involved in photosynthesis, signal transduction, carbohydrate metabolism, redox homeostasis, stress defense, and energy metabolism. DAPs associated with photosynthesis and protein folding showed significant downregulation and upregulation in response to water-deficit and high-N treatments, respectively. The combined treatment caused a moderate upregulation of DAPs related to photosynthesis and energy and carbohydrate metabolism, suggesting that high-N fertilization can alleviate losses in yield caused by water-deficit conditions by enhancing leaf photosynthesis and grain storage compound synthesis.
Associations between sexual assault and suicidal thoughts and behavior: A meta-analysis.

OBJECTIVE The goal of the present study was to conduct a quantitative review to determine the degree to which specific forms of suicidality (i.e., lifetime and past-year suicidal ideation and attempts) are associated with sexual assault (SA). It also examined whether the strength of the association between SA and suicidality was moderated by sample characteristics or the type of suicidality assessed. METHOD A subset of studies (25 samples and 36 effects, reflecting N = 88,376 participants) from a prior meta-analysis assessing associations between SA and psychopathology was examined. Included studies provided the prevalence of suicidality in subsamples that had and had not been exposed to SA and/or an odds ratio comparing the prevalence in these groups. Random effects metaregression models aggregated prevalence estimates and odds ratios for lifetime and past-year suicidal ideation and suicide attempts in individuals in SA and no-SA groups. Analyses also examined whether sample characteristics (i.e., percent women, college sample) or type of suicidality moderated the magnitude of odds ratios. RESULTS Subsamples exposed to SA reported a substantially higher prevalence of suicidality (27.25%) compared with unassaulted subsamples (9.37%). There were significantly higher rates of lifetime and past-year suicidal ideation, and lifetime suicide attempts in assaulted subsamples than in unassaulted subsamples. No tested moderators had significant associations with the strength of the relationship between SA and suicidality. CONCLUSION Findings underscore the robust relationship between SA and both suicidal ideation and attempts and suggest that identifying moderators and mediators that explain it is a key directive for future research. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
Acute effects of in-step and wrist weights on change of direction speed, accuracy and stroke velocity in junior tennis players

The main aim of this study was to investigate the acute effects of the use of a weighting set (Powerinstep®) on measures of stroke velocity (StV), accuracy and change of direction speed (CODS) in junior tennis players. A within-subjects design was used to evaluate seventeen (6 female and 11 male) tennis players (mean ± SD; 16.5 ± 1.3 years old; 1.75 ± 8.4 m; 67.0 ± 8.1 kg; 22.04 ± 1.8 kg/m2) on StV of three specific tennis actions (serve, forehand and backhand) and CODS for the following conditions: wearing a 50, 100, 150, 200 g weight or no weight at all (baseline). No significant differences were found between conditions for forehand (F = 0.412; p = 0.799), backhand (F = 0.269; p = 0.897) and serve (F = 0.541; p = 0.706) velocity and forehand (F = 1.688; p = 0.161), backhand (F = 0.567; p = 0.687) and serve (F = 2.382; p = 0.059) accuracy and CODS (F = 0.416; p = 0.797). Small-to-moderate effect sizes (ES) negatively affecting StV when using 200 g compared to the baseline (ES = 0.48, 0.35 and 0.45) could be observed. Moderate (ES = -0.49) and trivial (ES = -0.14 and -0.16) ES for a higher accuracy score were noticed in serve, forehand and backhand 100 g compared to the baseline. Moreover, small ES (ES = 0.41) for improvement in 200 g CODS comparing to baseline conditions were found. These results indicate that the use of a weighting set does not significantly affect StV or CODS respectively. Notwithstanding, small-to-moderate changes show impact in accuracy and no variance in velocity production when using 100 g alongside faster execution in CODS when using 200 g.
Child health research and planning in Europe disadvantaged by major gaps and disparities in published statistics.

BACKGROUND Population data, such as mortality and morbidity statistics, are essential for many reasons, including giving context for research, supporting action on health determinants, formulation of evidence-based policy for health care and outcome evaluation. However, when considering children, it is difficult to find such data, despite children comprising one-fifth of the European population and being in a key formative life stage and dependent on societal support. Moreover, it would be expected that there should be confidence in the key child health data available, with little to no discrepancy between recognized health statistic databases. METHODS This study explored the main health databases in or including Europe to collate child mortality data, for both all-cause and specific-cause mortality. Tables were constructed for comparison of values and rankings. RESULTS The results show that there are major differences in reported mortality data between two prominent health statistic databases, difference in coding systems, and unannounced changes within one of the databases. CONCLUSIONS The lack of health data for children seems compounded by challenges to the trust and credibility, which are vital if these data are to have utility. Children and society are the losers, and resolution is needed as a priority.
Sperm Cohort-Specific Zinc Signature Acquisition and Capacitation-Induced Zinc Flux Regulate Sperm-Oviduct and Sperm-Zona Pellucida Interactions

Building on our recent discovery of the zinc signature phenomenon present in boar, bull, and human spermatozoa, we have further characterized the role of zinc ions in the spermatozoa’s pathway to fertilization. In boar, the zinc signature differed between the three major boar ejaculate fractions, the initial pre-rich, the sperm-rich, and the post-sperm-rich fraction. These differences set in the sperm ejaculatory sequence establish two major sperm cohorts with marked differences in their sperm capacitation progress. On the subcellular level, we show that the capacitation-induced Zn-ion efflux allows for sperm release from oviductal glycans as analyzed with the oviductal epithelium mimicking glycan binding assay. Sperm zinc efflux also activates zinc-containing enzymes and proteases involved in sperm penetration of the zona pellucida, such as the inner acrosomal membrane matrix metalloproteinase 2 (MMP2). Both MMP2 and the 26S proteasome showed severely reduced activity in the presence of zinc ions, through studies using by gel zymography and the fluorogenic substrates, respectively. In the context of the fertilization-induced oocyte zinc spark and the ensuing oocyte-issued polyspermy-blocking zinc shield, the inhibitory effect of zinc on sperm-borne enzymes may contribute to the fast block of polyspermy. Altogether, our findings establish a new paradigm on the role of zinc ions in sperm function and pave the way for the optimization of animal semen analysis, artificial insemination (AI), and human male-factor infertility diagnostics.