Miracle-dz/UniFAR-FTUs huggingface dataset:
Surface modification and wettability of silicone PDMS film

In this work, silicone PDMS (polydimethylsiloxane) films were deposited on 100 mm silicon wafer by spin-coating technique and its surface is modified by plasma CHF3 and O2 treatment in a vacuum chamber, respectively. Wettable surface is obtained through subsequent plasma O2 treatment. Scanning Electron Microscope (SEM) and Energy dispersive x-ray spectroscopy (EDX) indicate that the plasma CHF3 treatment induces the formation of island-like nano-structures. The chemical composition of the island-like nano-structures is silicon-rich in near surface region. The surface roughness increases from 9 nm to 230 nm as plasma treatment time increases from 0 to 40 minutes. The wettability of the PDMS surface is strongly dependent on its roughness and the time of plasma O2 treatment. A typical contact angle of 5 µL water droplet after aging 25 hours at room temperature is about 35 ° on the PDMS surface with roughness 230 nm.
Maintaining arm control during self-triggered and unpredictable unloading perturbations

We often perform actions where we must break through some resistive force, but want to remain in control during this unpredictable transition; for example, when an object we are pushing on transitions from static to dynamic friction and begins to move. We designed a laboratory task to replicate this situation in which participants actively pushed against a robotic manipulandum until they exceeded an unpredictable threshold, at which point the manipulandum moved freely. Human participants were instructed to either stop the movement of the handle following this unloading perturbation, or to continue pushing. We found that participants were able to modulate their reflexes in response to this unpredictable and self-triggered unloading perturbation according to the instruction they were following, and that this reflex modulation could not be explained by pre-perturbation muscle state. However, in a second task, where participants reactively produced force during the pre-unloading phase in response to the robotic manipulandum to maintain a set hand position, they were unable to modulate their reflexes in the same task-dependent way. This occurred even though the forces they produced were matched to the first task and they had more time to prepare for the unloading event. We suggest this disparity occurs because of different neural circuits involved in posture and movement, meaning that participants in the first task did not require additional time to switch from postural to movement control.
Early Detection of Adverse Drug Reactions in Social Health Networks: A Natural Language Processing Pipeline for Signal Detection

Background Adverse drug reactions (ADRs) occur in nearly all patients on chemotherapy, causing morbidity and therapy disruptions. Detection of such ADRs is limited in clinical trials, which are underpowered to detect rare events. Early recognition of ADRs in the postmarketing phase could substantially reduce morbidity and decrease societal costs. Internet community health forums provide a mechanism for individuals to discuss real-time health concerns and can enable computational detection of ADRs. Objective The goal of this study is to identify cutaneous ADR signals in social health networks and compare the frequency and timing of these ADRs to clinical reports in the literature. Methods We present a natural language processing-based, ADR signal-generation pipeline based on patient posts on Internet social health networks. We identified user posts from the Inspire health forums related to two chemotherapy classes: erlotinib, an epidermal growth factor receptor inhibitor, and nivolumab and pembrolizumab, immune checkpoint inhibitors. We extracted mentions of ADRs from unstructured content of patient posts. We then performed population-level association analyses and time-to-detection analyses. Results Our system detected cutaneous ADRs from patient reports with high precision (0.90) and at frequencies comparable to those documented in the literature but an average of 7 months ahead of their literature reporting. Known ADRs were associated with higher proportional reporting ratios compared to negative controls, demonstrating the robustness of our analyses. Our named entity recognition system achieved a 0.738 microaveraged F-measure in detecting ADR entities, not limited to cutaneous ADRs, in health forum posts. Additionally, we discovered the novel ADR of hypohidrosis reported by 23 patients in erlotinib-related posts; this ADR was absent from 15 years of literature on this medication and we recently reported the finding in a clinical oncology journal. Conclusions Several hundred million patients report health concerns in social health networks, yet this information is markedly underutilized for pharmacosurveillance. We demonstrated the ability of a natural language processing-based signal-generation pipeline to accurately detect patient reports of ADRs months in advance of literature reporting and the robustness of statistical analyses to validate system detections. Our findings suggest the important contributions that social health network data can play in contributing to more comprehensive and timely pharmacovigilance.
Benefits of ion mobility for analysing monochloropropane-diol esters

ABSTRACT This paper reports the first application and benefits of ion mobility in combination with liquid chromatography and a transportable time-of-flight mass spectrometer to the analysis of monochloropropane-diol esters (MCPDE) in vegetable oils. The additional selectivity obtained with the ion mobility allowed the quantitative analysis of MCPDEs as such in their intact form (direct analysis) without any chemical derivatisation and, furthermore, without any enrichment or purification step. This gain in selectivity manifests primarily in the resolution of interferences originating, for example, from the diacylglycerol components of palm oil. In silico calculations confirm that resolution of such interferences would require mass resolutions higher than 200,000 at m/z 600, e.g., in the case of signals of the 41K isotope of the PO DAG and the signals of the sodiated PO MCPD. While such resolution can be obtained on certain state-of-the-art costly and laboratory-exhaustive research instruments, this study demonstrates that even transportable time-of-flight MS can achieve the required selectivity when combined with ion mobility. Further advantage of the described approach is that the applied sample preparation is only dilution with minimum consumable requirements and can be performed quickly even outside laboratories directly in the field. The described results suggest that the application of ion mobility in addition to LC-MS is likely to push the boundaries of contaminant analysis especially for high-throughput screening investigations. GRAPHICAL ABSTRACT
Characteristics of Daily E-Cigarette Use and Acquisition Means Among a National Sample of Adolescents

Purpose: To examine the relationship between several e-cigarette-related characteristics and daily e-cigarette use among adolescent current users. Design: Secondary analysis of 2016 National Youth Tobacco Survey data. Setting: United States middle schools and high schools. Sample: One thousand five hundred seventy-nine current e-cigarette users. Measures: Daily e-cigarette use and e-cigarette flavors, brands, device type, and acquisition were measured. Analysis: Logistic regression and Poisson regression models were built. Results: A total of 13.6% of current users reported daily use. Results indicated that daily users were at increased odds of using all flavor types (all P < .001), with the exception of menthol/mint, and using a higher number of flavors than nondaily users (P < .001). Daily users were more likely to use Blu, eGo, Logic, Halo, NJOY, and another unlisted brand but less likely to report they did not know the brand used (all P ≤ .01). Daily users also reported using a higher number of brands than nondaily users (P < .001). Daily users were at increased odds of using marijuana/tetrahydrocannabinol (THC) oil wax as device ingredients (P < .001) and less likely to use only nicotine (P < .001) or unknown ingredients (P = .004). Daily users were more likely to acquire e-cigarettes from a vape shop, gas station/convenience store, Internet, mall/shopping center kiosk, drug store, grocery store, or other place (all P ≤ .01). Conclusion: Comprehensive efforts are needed to reduce e-cigarette use and nicotine addiction among adolescents.
Performance Evaluation of RAKE Receiver for UWB Systems using Measured Channels in Industrial Environments

The industrial environments are an important scenario for ultra wideband (UWB) communication systems. However, due to large number of metallic scatterers in the surroundings, the multipath offered by UWB channels is dense with significant energy. In this paper, the performance of RAKE receivers operating in a non line-of-sight (NLOS) scenario in these environments is evaluated. The channels used for the evaluation are measured in a medium-sized industrial environment. In addition, a standard IEEE 802.15. 4a channel model is used for comparison with the results of the measured data. The performance of partial RAKE (PRake) and selective RAKE (SRake)is evaluated in terms of uncoded bit-error-rate (BER) using different number of fingers. The performance of maximal ratio combining (MRC) and equal gain combining (EGC) is compared for the RAKE receiver assuming perfect knowledge of the channel state. Finally, based on the simulation results, conclusions are drawn considering the performance and complexity issues for system design in these environments.
RNA Sequencing Analysis of Chicken Cecum Tissues Following Eimeria tenella Infection in Vivo

Eimeria tenella (E. tenella) is one of the most frequent and pathogenic species of protozoan parasites of the genus Eimeria that exclusively occupies the cecum, exerting a high economic impact on the poultry industry. To investigate differentially expressed genes (DEGs) in the cecal tissue of Jinghai yellow chickens infected with E. tenella, the molecular response process, and the immune response mechanism during coccidial infection, RNA-seq was used to analyze the cecal tissues of an E. tenella infection group (JS) and an uninfected group (JC) on the seventh day post-infection. The DEGs were screened by functional and pathway enrichment analyses. The results indicated that there were 5477 DEGs (p-value < 0.05) between the JS and the JC groups, of which 2942 were upregulated, and 2535 were downregulated. GO analysis indicated that the top 30 significantly enriched GO terms mainly involved signal transduction, angiogenesis, inflammatory response, and blood vessel development. KEGG analysis revealed that the top significantly enriched signaling pathways included focal adhesion, extracellular matrix–receptor interaction, and peroxisome proliferator-activated receptor. The key DEGs in these pathways included ANGPTL4, ACSL5, VEGFC, MAPK10, and CD44. These genes play an important role in the infection of E. tenella. This study further enhances our understanding of the molecular mechanism of E. tenella infection in chickens.
Cosmological dynamics on the brane

In Randall-Sundrum-type brane-world cosmologies, the dynamical equations on the three-brane differ from the general relativity equations by terms that carry the effects of embedding and of the free gravitational field in the five-dimensional bulk. Instead of starting from an ansatz for the metric, we derive the covariant nonlinear dynamical equations for the gravitational and matter fields on the brane, and then linearize to find the perturbation equations on the brane. The local energy-momentum corrections are significant only at very high energies. The imprint on the brane of the nonlocal gravitational field in the bulk is more subtle, and we provide a careful decomposition of this effect into nonlocal energy density, flux and anisotropic stress. The nonlocal energy density determines the tidal acceleration in the off-brane direction, and can oppose singularity formation via the generalized Raychaudhuri equation. Unlike the nonlocal energy density and flux, the nonlocal anisotropic stress is not determined by an evolution equation on the brane, reflecting the fact that brane observers cannot in general make predictions from initial data. In particular, isotropy of the cosmic microwave background may no longer guarantee a Friedmann geometry. Adiabatic density perturbations are coupled to perturbations in the nonlocal bulk field, and in general the system is not closed on the brane. But on super- Hubble scales, density perturbations satisfy a decoupled third-order equation, and can be evaluated by brane observers. Tensor perturbations on the brane are suppressed by local bulk effects during inflation, while nonlocal effects can serve as a source or a sink. Vorticity on the brane decays as in general relativity, but nonlocal bulk effects can source the gravito-magnetic field, so that vector perturbations can be generated in the absence of vorticity.
Celebration Drinking around the Clock

ABSTRACT The fact that St. Patrick’s Day (SPD) celebration drinking occurs during a specified, public, and socially-acceptable time frame which spans the better part of a day and evening makes it an important time to understand and attempt to influence celebration drinking behaviors among young adults. SPD has been identified as the celebration during which college students consume more alcohol than any other point during the school year. Intervention opportunities can be more successful with an understanding of the factors associated with alcohol consumption at specific times on particular celebrations. This study examined the factors associated with celebration drinking at different time periods on SPD which included perceived descriptive and injunctive norms, the numbers of close friends and acquaintances present, social media relationships, demographic variables, past drinking behavior, and intent to drink on SPD at the three time points of interest. Findings showed variability in the predictive factors on SPD celebration drinking at different times of the day. The theoretical and practical intervention implications of the findings are discussed.
SAW and BAW technologies for RF filter applications: A review of the relative strengths and weaknesses

Acoustic filter technologies based on piezoelectric materials play a key role in wireless communication as they guarantee spectral integrity of RF signals. SAW filters have been used for this purpose since the early days of mobile phones. BAW filters are a relatively recent addition to the technology portfolio. Each technology claims to have unique advantages over the other. This paper gives a detailed review of the strength and weaknesses for both technologies. The aspects covered include process complexity, unique features, performance parameters and limitations. The application space for RF filters will be mapped out to identify areas where either SAW or BAW dominates or where they compete. Both technologies follow a steep path of improvements which involves introducing new materials, processes and design methods. Rivalry put aside there are many areas where advanced SAW and BAW can benefit from each other.
Discovery and antitumor evaluation of novel inhibitors of spermine oxidase

Abstract Increasing knowledge of the relationship between cancer and dysregulated polyamine catabolism suggests interfering with aberrant polyamine metabolism for anticancer therapy that will have considerable clinical promise. SMO (spermine oxidase) plays an essential role in regulating the polyamines homeostasis. Therefore, development of SMO inhibitors has increasingly attracted much attention. Previously, we successfully purified and characterised SMO. Here, we presented an in silico drug discovery pipeline by combining pharmacophore modelling and molecular docking for the virtual screening of SMO inhibitors. In vitro evaluation showed that N-(3-{[3-(dimethylamino)propyl]amino}propyl)-8-quinolinecarboxamide (SI-4650) inhibited SMO enzyme activity, increased substrate spermine content and reduced product spermidine content, indicating that SI-4650 can interfere with polyamine metabolism. Furthermore, SI-4650 treatment suppressed cell proliferation and migration. Mechanistically, SI-4650 caused cell cycle arrest, induced cell apoptosis, and promoted autophagy. These results demonstrated the properties of interfering with polyamine metabolism of SI-4650 as a SMO inhibitor and the potential for cancer treatment.
Pattern matching using morphological probing

In this paper, we introduce two new morphological transforms for pattern matching in gray scale images. They rely on a profiling approach and are defined in the context of mathematical morphology. The first transform allows to detect all occurrences of a single pattern in an image, which justifies the name SOMP (single object matching using probing). It is shown to have the properties of a metric and therefore returns a measure of similarity between the search image and the reference pattern. Other properties relative to noise and computation time are highlighted. The second transform MOMP (multiple objects matching using probing) offers the ability to locate multiple patterns simultaneously. It is particularly suited to the detection of objects varying in size and with noisy distortion. Some results are presented for both transforms.
A Comprehensive Patent Review on β-cyclodextrin Cross-linked Nanosponges for Multiple Applications.

BACKGROUND Currently, the most important challenge in the development of therapeutics and actives is their poor aqueous solubility and bioavailability. OBJECTIVE The low aqueous solubility, poor pharmacokinetic properties, and bioavailability associated with novel actives manifests in numerous challenges in the formulation of conventional dosage forms like tablets, capsules, suspensions, emulsions, etc. Nanosponges are a novel class of drug delivery system capable of encapsulating or entrapping both lipophilic and hydrophilic drugs. Target-specific drug delivery and controlled drug release are the advantages offered by nanosponges which make them a promising anti-tumor drug delivery system. METHOD Nanosponges are colloidal structures comprising solid nanoparticles with cavities and mesh-like structures for encapsulation of wide varieties of substances like antineoplastic agents, proteins and peptides, volatile oils, genetic material, etc. The methods of preparation of β-cyclodextrin-based nanosponges include solvent evaporation method, emulsion solvent evaporation method, ultrasound-assisted synthesis, hyper cross-linked cyclodextrin and interfacial phenomenon method. A large variety of nanosponges-based formulations are available in the market and some formulations of prostavastin, brexin, glymesason, mena-gargle, etc. are under clinical trials. RESULTS Nanosponges possess potential applications in target site-specific drug delivery to liver, spleen, and lungs. Due to the surface functionalization, nanosponges show broad applications in water purification, protein delivery, chemical sensors, detection of explosives, agriculture, etc. In the near future, nanosponges-based products will capture a huge market for commercialization due to their improved properties and advantages. CONCLUSION This review provides an account of the patents related to nanosponges (2006-2018) and covers the broad applications of β-cyclodextrin-based nanosponges, their roles in vaccine delivery, cancer therapy, fire engineering, water purification, etc.
Microbial Community Structure in the Sediments and Its Relation to Environmental Factors in Eutrophicated Sancha Lake

To study the microbial community structure in sediments and its relation to eutrophication environment factors, the sediments and the overlying water of Sancha Lake were collected in the four seasons. MiSeq high-throughput sequencing was conducted for the V3–V4 hypervariable regions of the 16S rRNA gene and was used to analyze the microbial community structure in sediments. Pearson correlation and redundancy analysis (RDA) were conducted to determine the relation between microbial populations and eutrophic factors. The results demonstrated four main patterns: (1) in the 36 samples that were collected, the classification annotation suggested 64 phyla, 259 classes, 476 orders, 759 families, and 9325 OTUs; (2) The diversity indices were ordered according to their values as with summer > winter > autumn > spring; (3) The microbial populations in the four seasons belonged to two distinct characteristic groups; (4) pH, dissolved oxygen (DO), total phosphorus (TP), and total nitrogen (TN) had significant effects on the community composition and structure, which further affected the dissolved total phosphorus (DTP) significantly. The present study demonstrates that the microbial communities in Sancha Lake sediments are highly diverse, their compositions and distributions are significantly different between spring and non-spring, and Actinobacteria and Cyanobacteria may be the key populations or indicator organisms for eutrophication.
Low-Dose Stevia (Rebaudioside A) Consumption Perturbs Gut Microbiota and the Mesolimbic Dopamine Reward System

Stevia is a natural low-calorie sweetener that is growing in popularity in food and beverage products. Despite its widespread use, little is understood of its impact on the gut microbiota, an important environmental factor that can mediate metabolism and subsequent obesity and disease risk. Furthermore, given previous reports of dysbiosis with some artificial low-calorie sweeteners, we wanted to understand whether prebiotic consumption could rescue potential stevia-mediated changes in gut microbiota. Three-week old male Sprague–Dawley rats were randomized to consume: (1) Water (CTR); (2) Rebaudioside A (STV); (3) prebiotic (PRE); (4) Rebaudioside A + prebiotic (SP) (n = 8/group) for 9 weeks. Rebaudioside was added to drinking water and prebiotic oligofructose-enriched inulin added to control diet (10%). Body weight and feces were collected weekly and food and fluid intake biweekly. Oral glucose and insulin tolerance tests, gut permeability tests, dual X-ray absorptiometry, and tissue harvest were performed at age 12 weeks. Rebaudioside A consumption alone did not alter weight gain or glucose tolerance compared to CTR. Rebaudioside A did, however, alter gut microbiota composition and reduce nucleus accumbens tyrosine hydroxylase and dopamine transporter mRNA levels compared to CTR. Prebiotic animals, alone or with Rebaudioside A, had reduced fat mass, food intake, and gut permeability and cecal SCFA concentration. Adding Rebaudioside A did not interfere with the benefits of the prebiotic except for a significant reduction in cecal weight. Long-term low-dose Rebaudioside A consumption had little effect on glucose metabolism and weight gain; however, its impact on gut microbial taxa should be further examined in populations exhibiting dysbiosis such as obesity.