Miracle-dz/UniFAR-FTUs huggingface dataset:
IL4 and IFNalpha generation of dendritic cells reveals great migratory potential and NFkB and cJun expression in IL4DCs

Dendritic cells (DCs) recently revealed as a potent tumor vaccine component, are commonly differentiated from monocytes by cultivation with IL-4 and GM-CSF. Despite the different opinions, the use of IFNalpha can promote DCs differentiation and activation. The aim of this study was to compare the functionality and phenotypic characterization of monocyte-derived DC generated by IL-4 (IL4DC) and IFNalpha (IFNalphaDC) modified protocols. To this aim, we investigated the expression of maturation markers, co-stimulatory molecules, relevant miRNA, cytokine and migratory profiles and the functional ability of these cells to stimulate autologous T cells in vitro. We herein investigated the molecular mechanism underlying the parameters previously described, as the relative expression of NF-kB p65, c-fos and c-jun, transcription factors. Our results demonstrated that IL4DC presented a stable phenotype, an increase in migratory capacity and NF-KB activation, in addition to lower levels of miR-146 a and miR-221. We believe that the IL4DC migratory potential and increase in NFkBp65 expression may be involved in higher IL12 expression and migration, suggesting a preferential activation of TH1 immune responses by IL4DC.
Interference and forgetting.

I know of no one who seriously maintains that interference among tasks is of no consequence in the production of forgetting. Whether forgetting is conceptualized at a strict psychological level or at a neural level (e.g., neural memory trace), some provision is made for interference to account for at least some of the measured forgetting. The many studies on retroactive inhibition are probably responsible for this general agreement that interference among tasks must produce a sizable proportion of forgetting. By introducing an interpolated interfering task very marked decrements in recall can be produced in a few minutes in the laboratory. But there is a second generalization which has resulted from these studies, namely, that most forgetting must be a function of the learning of tasks which interfere with that which has already been learned (19). Thus, if a single task is learned in the laboratory and retention measured after a week, the loss has been attributed to the interference from activities learned outside the laboratory during the week. It is this generalization with which I am concerned in the initial portions of this paper. Now, I cannot deny the data which show large amounts of forgetting produced by an interpolated list in a few minutes in the laboratory. Nor do I deny that this loss may be attributed to interference. But I will try to show 1 Address of the president, Midwestern Psychological Association, St. Louis, Missouri,
The identification of Mycoplasma mycoides mycoides LC as the aetiological agent of balanoposthitis and vulvovaginitis in sheep in South Africa.

Clinical ulcerative balanoposthitis and vulvovaginitis was experimentally reproduced in 14 sheep infected with a Mycoplasma mycoides mycoides LC field strain, isolated from the Straussheim Dorper stud. The study encompassed a series of field observations, a therapeutic trial and experimental investigations. A wide range of bacteria and various mycoplasma spp. , but no viruses, were isolated from a large number of infected animals.
Scalable P2P Search

Although the traditional client-server model first established the Web's backbone, it tends to underuse the Internet's bandwidth and intensify the burden that dedicated servers face as their load increases. ' Peer-to-peer computing relies on individual computers' computing power and storage capacity to better utilize bandwidth and distribute this load in a self-organizing manner. In P2P, nodes (or peers) act as both clients and servers, form an application-level network, and route messages (such as requests to locate a resource). The design of these routing protocols is of paramount importance to a P2P application's efficiency: naive approaches - such as Gnutella's flood routing, for example - can add traffic. P2P systems that exhibit the "small world" property - in which most peers have few links to other peers, but a few of them have many - are robust to random attacks, but can be highly vulnerable to targeted ones. P2P computing also has the potential to enhance reliability and fault tolerance because it doesn't rely on dedicated servers. ' Each peer maintains a local directory with entries to the resources it manages. It can also cache other peers' directory entries. Important applications of P2P technologies include distributed directory systems, new e-commerce models, and Web service discovery, all of which require efficient resource-location mechanisms.
Expansion and functional activity of Ly‐1+ B cells upon transfer of peritoneal cells into allotype‐congenic, newborn mice

Transfer of peritoneal cells from adult donors into newborn, allotype‐congenic mice led to colonization of the recipient mice by donor‐derived B lymphocytes expressing the Ly‐1 surface marker (Ly‐1 B cells). These cells not only persisted in the recipient mice for at least 5 months, but also increased in number. In contrast, bone marrow‐derived stem cells did not or scarcely give rise to B cells after intraperitoneal injection into congenic newborn recipients under the same experimental conditions.
Evaluation of energy consumption by nodes of MANET

Nodes in mobile ad hoc networks consume energy in different modes which greatly depletes finite energy resulting in reduced lifetime of network. Under energy constrained operations, it is ideal to optimize energy use for extending network lifetime. We have evaluated the energy consumption of Ad-Hoc On-Demand Distance Vector(AODV), Dynamic Source Routing(DSR) and The Dynamic MANET On-Demand (DYMO) routing protocol using MICAZ Energy Model, by creating a scenario involving 30 nodes(default device types) in one subnet, with CBR traffic under Random Waypoint mobility model (Pause time=3 sec., Min speed=0mps and max speed=10mps). Total items to send are 100 (512 bytes each, interval =.1sec, start time=1, end time=101) with simulation time of 101 seconds in QualNet 5.0 discrete event simulator. The statistics are generated and recorded for these experiments carried out in simulation area of 1500 × 1500 mt.2 by choosing AODV, DSR and DYMO protocols from QualNet 5.0 Simulator. The total energy consumption values for the three routing protocols are equivalent. Contribution of energy consumed at idle mode is maximum in overall energy consumption in different cases.
Development and comparative evaluation of power management systems for advanced photovoltaic architectures

This paper introduces a full comparative evaluation of the advanced PV architectures especially for energy harvest application. The comparative evaluation involves module architecture, sub-module architecture, and cell architecture. The comparison includes the capability of theses PV architectures to mitigate the effect of the mismatch loss that inherently comes from different irradiation on the PV system. Then, the effect of the bypass diodes on the PV performance under these three architectures is also considered. A case study is demonstrated to validate the different features of the mentioned PV architectures using PV module consists of 24 PV cells. Finally, simulation and experimental results for PV cell architectures using buck-boost converter is presented to investigate the features of the PV cell architecture and its challenges in the future.
Secondary Prevention of Intimate Partner Violence: A Randomized Controlled Trial

Background: Despite the recognition of intimate partner violence (IPV) against women as a global health issue associated with significant morbidity and mortality, evidence-based treatment strategies for primary care settings are lacking. Objective: To assess the comparative safety behaviors, use of community resources, and extent of violence following two levels of intervention. Methods: A randomized, two-arm, clinical trial was completed in urban public primary care clinics with 360 abused women who assessed positive for physical or sexual abuse within the preceding 12 months. Two interventions were tested: a wallet-sized referral card and a 20-minute nurse case management protocol. Outcome measures were differences in the number of threats of abuse, assaults, danger risks for homicide, events of work harassment, safety behaviors adopted, and use of community resources between intervention groups over a 24-month period. Results: Two years following treatment, both treatment groups of women reported significantly (p <.001) fewer threats of abuse (M = 14.5; 95% CI 12.6, 16.4), assaults (M = 15.5, 95% CI 13.5, 17.4), danger risks for homicide (M = 2.6; 95% CI 2.1, 3.0), and events of work harassment (M = 2.7; 95% CI 2.3, 3.1), but there were no significant differences between groups. Compared to baseline, both groups of women adopted significantly (p <.001) more safety behaviors by 24 months (M = 2.0; 95% CI 1.6, 2.3); however, community resource use declined significantly (p <.001) for both groups (M = −0.2; 95% CI −0.4,−0.2). There were no significant differences between groups. Discussion: Disclosure of abuse, such as what happens with abuse assessment, was associated with the same reduction in violence and increase in safety behaviors as a nurse case management intervention. Simple assessment for abuse and offering of referrals has the potential to interrupt and prevent recurrence of IPV and associated trauma.
Carbon Nanotubes: a viable drug delivery platform for the treatment of cancer -

Article history: Received on: 21/03/2015 Revised on: 07/04/2015 Accepted on: 09/05/2015 Available online: 27/09/2015 The development of new drug delivery platforms and specific vectorization processes for the treatment of diseases like cancer has become vitally important for the pharmaceutical industry. One of these new platforms are functionalized carbon nanotubes (f-CNTs), which are characterized by their high aspect ratio, high loading capacity, rich surface chemistry with functional groupsfor binding drugs and molecules. It has been demonstrated that functionalization processes of CNTs generate a marked decrease in toxicity, which makes them ideal candidates for clinical studies for their use as drug vectors.
Recruitment of Activated G Protein-coupled Receptors to Pre-existing Clathrin-coated Pits in Living Cells*

The process of clathrin-mediated endocytosis tightly regulates signaling of the superfamily of seven-transmembrane G protein-coupled receptors (GPCRs). A fundamental question in the cell biology of membrane receptor endocytosis is whether activated receptors can initiate the formation of clathrin-coated pits (CPs) or whether they are simply mobilized to pre-existing CPs. Here, using various approaches, including a dynamic assay to monitor the distribution of CPs and GPCR-β-arrestin complexes in live HeLa cells, we demonstrate for the first time that activated GPCRs do not initiate thede novo formation of CPs but instead are targeted to pre-existing CPs.
Automatic speed control of an asymmetrical six-phase induction motor using emotional controller (BELBIC)

An induction motor IM with two sets of three-phase windings in stator is called a six-phase IM SPIM. SPIM has lower torque pulsation compared to a three-phase IM and using SPIM, the power rating of inverter legs can be reduced. This paper offers a high performance intelligent controller for speed automatic control of a SPIM. A brain emotional learning based intelligent controller BELBIC is proposed as the speed controller. This emotional controller has simple structure with high auto learning feature and it is independent of parameters variations. A direct vector control in rotor flux frame based on space vector pulse width modulation SVPWM is used to decouple flux and torque control of the SPIM like a conventional three-phase machine. In this work, the d-axis current and speed reference signals are accurately tracked. An overview of the BELBIC is provided. A comparison with the conventional PI controller and Sliding Mode Control SLMC points out the superiority of the proposed BELBIC in speed response and torque ripple. Experimental results indicate that the BELBIC achieves a good speed regulation with a less control effort and torque ripple.
Cognitive deficits in the remitted state of unipolar depressive disorder.

BACKGROUND Patients with unipolar depressive disorder may present with cognitive deficits in the remitted state, and the aim of the present study was to investigate whether cognitive deficits within specific cognitive domains are present. METHOD Via the Danish registers (Civil Person Register, Danish Psychiatric Register) we identified individuals between 40 and 80 years of age with a diagnosis of unipolar disorder at their first discharge from a psychiatric hospital, and a gender- and age-matched control group. Particular emphasis was placed on assuring that patients were in a remitted state. Cognitive function was assessed with a broad range of neuropsychological tests. RESULTS A total of 88 patients and 50 controls were included in the study. In multiple linear regression analyses with simultaneous adjustment for age, gender, education level, premorbid IQ, and residual depressive symptoms, a diagnosis of unipolar disorder predicted lower performance on the Trail Making Test, the Symbol Digit Modalities Test, and on the Stroop test. CONCLUSION Cognitive deficits are present in patients with unipolar disorder in the remitted state. The deficits seem to reside more within the cognitive domain of attention than within other domains, and may be characterized by impairment of processing speed and cognitive flexibility.
Ethics and trust in digital scholarship

Purpose – This paper aims to address issues of ethics and trust in a digital scholarship environment relating to: accuracy of data, integrity of scholarly research process, electronic publications and communications; intellectual property rights, confidentiality/privacy and data security. The paper raises such questions as: To what extent do faculty trust digital research process? How can trust be nurtured in a scholarly environment where research is undertaken wholly or in part electronically? Design/methodology/approach – The paper is based on critical analysis of existing literature especially the theoretical models of ethics and trust drawn from across different disciplines such as marketing, psychology, management, and information systems.Findings – Despite the increasing adoption of digital scholarship strategies among universities, ethics and trust issues are not being addressed. In order for digital scholarship to be effectively integrated within the institutional operational milieu and institution.
Modulation of the triggering receptor expressed on myeloid cells-1 pathway during pneumonia in rats.

BACKGROUND Triggering receptor expressed on myeloid cells-1 (TREM-1) is a cell-surface molecule that has been identified on both human and murine polymorphonuclear neutrophils and mature monocytes. The activation of TREM-1 in the presence of microbial components amplifies the inflammatory response and may be responsible for the hyperresponsiveness observed during the initial stage of sepsis. The aim of the present study was to investigate the effect of the modulation of the TREM-1 pathway during experimental pneumonia in rats. METHODS Adult male Wistar rats were intratracheally inoculated with Pseudomonas aeruginosa (PAO1 strain) and randomly treated or not treated with an analogue synthetic peptide derived from the extracellular moiety of TREM-1 (LP17). RESULTS P. aeruginosa induced a severe pneumonia associated with signs of severe sepsis within the first 24 h. In septic rats, LP17 improved hemodynamic status, attenuated the development of lactic acidosis and hypoxemia, modulated lung and systemic inflammatory responses and coagulation activation, reduced lung histological damage, and improved survival. CONCLUSIONS The modulation of the TREM-1 pathway by the use of such synthetic peptides as LP17 appears beneficial during P. aeruginosa pneumonia in rats in attenuating lung and systemic inflammatory responses.
Identification and characterization of a novel gene that is upregulated in leukaemia cells by nitric oxide

Nitric oxide (NO) inhibits growth and induces differentiation in acute myeloid leukaemia (AML) cells. To identify genes associated with these processes, we studied the effect of NO on AML gene expression using the technique of Representational Difference Analysis. Exposure of HL‐60 cells to the NO donor DETA‐NO for 24 h induced the expression of a novel gene that was named rno (regulated by nitric oxide). Treatment of HL‐60 cells with dimethyl sulphoxide induced expression of rno, but treatment with Vitamin D3 or all‐trans retinoic acid did not. Upregulation of rno by NO was cGMP independent. Northern blot analysis indicated that constitutive expression of the novel gene was limited to leucocytes. Three isoforms of rno were identified. An rno cDNA clone was obtained by screening a human leucocyte library. The nucleotide sequence of the open reading frame shared significant homology with that of the human ribonuclease/angiogenin inhibitor (RI). The predicted amino acid sequence indicated that, like RI, rno is leucine and cysteine rich and is comprised of a series of repetitive elements (leucine‐rich repeats) that may mediate macromolecular interactions. Enhancement of expression of rno may be a component of the process by which differentiation and growth inhibition of leukaemia cells is induced by NO.
19 Differential Hybrid Games

This article introduces differential hybrid games, which combine differential games with hybrid games. In both kinds of games, two players interact with continuous dynamics. The difference is that hybrid games also provide all the features of hybrid systems and discrete games, but only deterministic differential equations. Differential games, instead, provide differential equations with continuous-time game input by both players, but not the luxury of hybrid games, such as mode switches and discrete-time or alternating adversarial interaction. This article augments differential game logic with modalities for the combined dynamics of differential hybrid games. It shows how hybrid games subsume differential games and introduces differential game invariants and differential game variants for proving properties of differential games inductively.
Approved lists of bacterial names.

At the meeting of the Judicial Commission of the ICSB held in Jerusalem on the 29th March, 1973 an Ad Hoc Committee was appointed (Minute 22) to organize a review of the currently valid names of bacteria with the object of retaining only names for those taxa which were adequately described and, if cultivable, for which there was a Type, Neotype or Reference strain available; to compile these names under the title of Approved Lists of Bacterial Names and to publish the lists in the International Journal of Systematic Bacteriology, to become effective on January 1, 1980.
High performance polysilicon nanowire NEMS for CMOS embedded nanosensors

We present for the first time sub-100nm poly-Silicon nanowire (poly-Si NW) based NEMS resonators for low cost cointegrated mass sensors on CMOS featuring excellent performance when compared to crystalline silicon. In particular, comparable quality factors (130 in the air, 3900 in vacuum) and frequency stabilities are demonstrated. The minimum measured Allan deviation of 7×10-7 leads to a mass resolution detection down to 100 zg (100×10-21 g). Moreover a novel method for in-line NW gauges factor (GF) extraction is proposed and used.
Spermatophagy in the Seminiferous Tubules and Excurrent Ducts of the Testis in Rhesus Monkey and in Man *

Die Ultrastruktur von Zellen, die zur Phagozytose von Spermatozoen im Hoden und Nebenhoden befähigt sind, wurde mit Hilfe der Transmissions‐ und Rasterelektronen‐mikroskopie untersucht. Es gibt ortsständige Zellen, wie Sertolizellen und Retteepithelzellen und freie Makrophagen (Spermatophagen) in den Lumina der Samenkanälchen und Nebenhodenkanälchen, die Spermatozoen oder Bruchstücke von ihnen phagozytieren können. Die Spermatophagen entstehen aus Vorläuferzellen, die aus dem Hoden‐Interstitium in die Tubuli seminiferi einwandern. Nach Phagozytose von Spermatozoen nehmen sie an Größe zu und enthalten manchmal mehrere Zellkerne. Große abgerundete Spermatophagen sind im Nebenhoden zu finden. Beim Affen konnte festgestellt werden, daß Spermatophagen im Bereich des Rete testis die Samenwege verlassen und in das subepitheliale Bindegewebe auswandern. Spermatophagie kommt gehäuft vor bei älteren Männern und in bestimmten Fällen von Oligozoospermie. Beim Affen treten zahlreiche Spermatophagen am Ende der spermatogenetischen Saison auf.
Reduction of α‐galactooligosaccharides in soyamilk by Lactobacillus fermentum CRL 722: in vitro and in vivo evaluation of fermented soyamilk

Aims: Consumption of soya‐derived products has been hampered by the presence of α‐galactooligosaccharides (α‐GOS) because mammals lack pancreatic α‐galactosidase (α‐Gal) which is necessary for their hydrolysis. These sugars thus reach the large intestine causing gastrointestinal disorders in sensitive individuals. The use of lactic acid bacteria (LAB) expressing α‐Gal is a promising solution for the degradation of α‐GOS in soyamilk.
Design and Performance of an Enhanced IEEE 802 . 11 MAC Protocol for Ad Hoc Networks

Ad hoc networks will be applied for coverage extension for existing wireless networks. Especially for upcoming WLAN hotspots this is a viable option to decrease installation costs. Unfortunately WLAN systems based on the IEEE802.11 standard lead to poor performance for such multi–hop networks. Therefore, we introduce a new MAC protocol for IEEE802.11 that needs only marginal changes in the standard, but offers high connectivity and high throughput values. We advocate the use of a common signaling channel for the task of assigning channels among wireless terminals in an IEEE802.11a based ad hoc network. Our approach separates the RTS/CTS signaling from the data exchange. By means of this separation all wireless nodes are forced to listen to one domain, on which the channel assignment process takes place. After a four way RTS/CTS handshake, data transmission occurs on a dedicated channel. Due to this new scheme collisions are reduced. The common signaling channel helps also to find the appropriate node for routing and achieves a high connectivity level among wireless nodes.
[Granulocyte colony-stimulating factor (G-CSF): biochemistry, biology and pathophysiology].

G-CSF belongs to a family of hematopoietic growth factors, also known as colony stimulating factors. It supports the growth and differentiation of predominantly committed neutrophil precursors and activates the function of peripheral blood neutrophils in vitro. In vivo studies in primates (Cynomolgus monkeys) demonstrated that G-CSF is a potent myeloid growth and differentiation factor causing a dose-dependent increase predominantly in the peripheral blood neutrophils. To assess the effects of G-CSF in chemotherapy induced cytopenias, we administered G-CSF to monkeys that had been treated with cyclophosphamide (60 mg/kg/dx2), or repeated cycles of busulfan (4, 6 or 10 mg/kg/dx3). In both, cyclophosphamide and busulfan induced myelosuppression, G-CSF in doses between 10 and 30 micrograms/kg/d was able to significantly shorten the time of neutropenia. In addition, monkeys were treated with G-CSF (50 or 100 micrograms/kg/d) for one month post autologous bone marrow transplantation following total body irradiation. The time of neutropenia (less than 1000 neutrophils/mm3) was shorter in the G-CSF treated monkeys (10 days in the 100 micrograms/kg/d treated monkey) compared to two controls (21 days). The post transplant absolute neutrophil count of approximately 30,000/mm3 could be maintained for the entire period of G-CSF exposure. (ABSTRACT TRUNCATED AT 250 WORDS)