Miracle-dz/UniFAR-FTUs huggingface dataset:
Early Reminiscing in Cultural Contexts: Cultural Models, Maternal Reminiscing Styles, and Children's Memories

The present study examined conversations of 164 mothers from seven different cultural contexts when reminiscing with their 3-year-old children. We chose samples based on their sociodemographic profiles, which represented three different cultural models: (1) autonomy (urban middle-class families from Western societies), (2) relatedness (rural farming families from non-Western societies), and (3) autonomy-relatedness (urban middle-class families from non-Western societies). The results showed that mothers from the autonomous contexts predominantly adopted an elaborative-evaluative reminiscing style (variable-oriented approach) and pattern (person-oriented approach). Mothers from the relational contexts mainly adopted a repetitive reminiscing style and pattern. There was greater heterogeneity for style variables among mothers from autonomous-relational contexts; in addition, the person-oriented approach revealed that the majority of mothers from autonomous-relational contexts showed hybrid style patterns. Thus, the cultural models, and their respective orientations towards autonomy and relatedness, were reflected in the way mothers reminisced with their children. The children's provision of memory elaborations was high in the autonomous contexts, low in the relational contexts, and moderate in the autonomous-relational contexts. Across contexts, maternal evaluations prompted children to contribute memory elaborations. Maternal elaborations were an additional predictor for children's memory, but only for families from the relational cultural model.
Improved Refolding Efficacy of Recombinant Human Interferon α-2b via pH Modulation

Purpose: To increase the refolding yield of Recombinant Human Interferon α-2b in order to achieve a highly potent product. Methods: Interferon α-2b inclusion body was dissolved in tris-HCl buffer containing 6 M guanidine-HCl and CuSO4. Different refolding buffers were employed for refolding the target protein. The refolded proteins were then purified by affinity and gel filtration chromatography. The purified proteins were subjected to circular dichroism (CD) spectropolarimetry and assayed for biological activity in vitro. Results: Increment of pH to 8.5 improved refolding efficacies from 42.28 % to 71.22 %. However, the relative potency significantly increased up to pH 8.0 (from 19353546 to 28633902, p < 0.05) and then decreased to 21081305.00 at pH 8.5. The CD spectra demonstrated that by increasing pH to 8.5, the secondary structure of the protein was altered, probably due to increase in alpha-helix from 23.7 % at pH 7.0 to 28.1 %. Conclusion: Employing a low-cost and simple method, such as alteration of refolding buffer pH, results in higher refolding yield in downstream processing of rhIFN α-2b.
Bfl‐1 is a crucial pro‐survival nuclear factor‐κB target gene in Hodgkin/Reed‐Sternberg cells

Hodgkin/Reed‐Sternberg (H/RS) cells are believed to represent clonal progeny of Germinal Centre B cells that have escaped negative selection by evading apoptosis. Aberrant constitutive activity of the transcription factor NF‐κB plays a key role in the pathogenesis of Hodgkin's Lymphoma (HL), conferring a survival advantage on H/RS cells. Bfl‐1 is a pro‐survival NF‐κB target gene from the Bcl‐2 family of apoptosis‐regulating proteins. Here, we report that bfl‐1 (also known as A1 or GRS) is frequently expressed in primary H/RS cells from HL tumor biopsies and that elevated bfl‐1 expression is a feature of H/RS derived cell lines. We show that bfl‐1 is an NF‐κB target gene in this cell context and that this regulation is effected through a p65‐binding DNA element located in its promoter. We demonstrate that ectopic Bfl‐1 can rescue cultured H/RS cells from apoptosis induced by pharmacological inhibitors of NF‐κB, and that knockdown of bfl‐1 potentiates the pro‐apoptotic effect of these agents. These findings are the first indication that Bfl‐1 plays a crucial role in setting the elevated threshold of resistance of this malignant cell type to apoptosis.
Optimal control of a particular class of singularly perturbed nonlinear discrete-time systems

This note studies a class of discrete-time nonlinear systems which depend on a small parameter. Using the singular perturbation theory in a systematic way, we give a trajectory approximation result based on the decomposition of the model into reduced and boundary layer models. This decomposition is used to analyze optimal control via maximum principle of such systems. As a result, significant order reduction of optimal control problems is achieved.
Nuclear and cytoplasmic DNA synthesis in adult and embryonic rotifers.

1. DNA synthesis has been studied in adult and embryonic tissues of the rotifer Asplanchna brightwelli. using autoradiography with tritiated thymidine.2. Mitosis and mitotic DNA synthesis cease, and nucleoli are formed, approximately simultaneously at the end of the mitotic phase of embryonic development.3. In the post-mitotic phase of development and in adult females, the large nuclei of the vitellarium (a nurse cell-like organ) incorporate H3-thymidine into metabolically-stable DNA, thus presumably becoming polyploid.4. The DNA synthesis in the different nuclei of the syncytial vitellarium is not synchronous, showing that the cytoplasm does not control nuclear DNA synthesis.5. Cytoplasmic DNA synthesis also occurs in embryos and in adult vitellaria. Most or all of the cytoplasmic DNA appears to be in the mitochondria.
Leukemia in children and youths of the Azuay province, Ecuador: 2000–2010

We mapped leukemia risk among children and youths in the Azuay province, Rio Paute river basin, Ecuador, in 2000–2010, using a Bayesian disease mapping model. We assessed the comprehensiveness of the list of leukemia cases from the Sociedad de Lucha contra el Càncer en el Ecuador (SOLCA) Hospital in Cuenca, the only referral center for oncology in the whole Rio Paute area, by comparison to the Quito cancer registry. Risk of leukemia did not vary significantly by canton within the Azuay province. However, a moderate increase in risk of borderline statistical significance was observed in the city of Cuenca and particularly among males in a heavily industrialized parish, who had an almost eight-fold excess (95% CI 3.03, 20.39, p = 0.01) of AML. Analytical studies are warranted to properly address specific etiological factor of leukemia among children and youths of the Azuay province of Ecuador.
Berry-phase-mediated topological thermoelectric transport in gapped single and bilayer graphene

We consider the anomalous thermoelectric transport in gapped single and bilayer graphene where the gap may be due to broken inversion symmetry. In the presence of the gap, nontrivial Berry phase effects can be shown to mediate a transverse thermoelectric voltage in response to an applied temperature gradient even in the absence of a perpendicular magnetic field. This spontaneous anomalous Nernst effect is nonzero for nonuniform chemical potential in the two inequivalent valleys in the graphene band structure. Conversely, the Nernst response can be used to create a valley-index polarization between the two transverse sample edges as in the analogous valley Hall effect.
A multiscale morphological method for human posture recognition

For the purpose of estimating the posture parameters of moving human bodies in visual surveillance applications, we present a model-based shape analysis method. The problem is converted to the optimal matching of the 2D silhouette of the human body in parametric shape space. We point out the causality of the area-difference-based shape similarity in morphological scale space, which contributes a lot to the robustness and reliability of the matching. Based on this causality, the method we propose works in a course-to-fine manner on cracked silhouettes practically segmented from complex environments, and can converge fast enough to meet real-time requirements.
Acceptable noise level (ANL) and real-world hearing-aid success in Taiwanese listeners

Abstract Objective: The objective of this prospective study was to investigate the relationship between acceptable noise level (ANL), which was measured using Taiwanese and the international speech test signal (ISTS), and real-world hearing-aid success for listeners who were representative of the population commonly seen in clinics. Design: Unaided ANLs were measured pre-hearing-aid fitting. Hearing-aid success was assessed three months post-fitting using the international outcome inventory for hearing aids (IOI-HA) and a hearing-aid use questionnaire. Study sample: Eighty adults with hearing impairment completed the study. Results: Both Taiwanese and ISTS ANLs were significantly associated with hearing-aid success, with higher ANLs suggesting poorer outcomes. However, the ANL's prediction accuracy for the probability of hearing-aid success was either much lower than that suggested by some literature, or was not much different from that of simply predicting all listeners as successful users. Conclusions: The current study suggested the possibility of using ANL to predict hearing-aid success. However, the usefulness of ANL as a clinical tool is unlikely to be as great as indicated by the literature.
Cyberbullying Detection based on text-stream classification

Current studies on cyberbullying detection, under text classification, mainly assume that the streaming text can be fully labelled. However, the exponential growth of unlabelled data in online content makes this assumption impractical. In this paper, we propose a session-based framework for automatic detection of cyberbullying from the huge amount of unlabelled streaming text. Given that the streaming data from Social Networks arrives in large volume at the server system, we incorporate an ensemble of one-class classifiers in the session-based framework. The proposed framework addresses the real world scenario, where only a small set of positive instances are available for initial training. Our main contribution in this paper is to automatically detect cyberbullying in real world situations, where labelled data is not readily available. Our early results show that the proposed approach is reasonably effective for the automatic detection of cyberbullying on Social Networks. The experiments indicate that the ensemble learner outperforms the single window and fixed window approaches, while learning is from positive and unlabelled data.
Semantic Enrichment and Search: A Case Study on Environmental Science Literature

As information discovery needs become more and more challenging, traditional keyword-based information retrieval methods are increasingly falling short in providing adequate support. The problem is often compounded by the poor quality of article metadata in some digital collections. This paper investigates automatic semantic enrichment and search methods, as ways to meet these challenges. In particular, the benefits of enriching articles with knowledge from Linked Open Data resources are investigated, with focus on the domain of environmental science. In order to facilitate environmental science researchers in carrying out better semantic searches, a form-based semantic search interface is proposed. It helps researchers to benefit from the semantically enriched content, e.g. to carry out sophisticated location-based searches. The usability and ease of learning of this web interface were evaluated in a user-based study, the results of which are also reported.
A New Algorithm for Positive Semidefinite Matrix Completion

Positive semidefinite matrix completion (PSDMC) aims to recover positive semidefinite and low-rank matrices from a subset of entries of a matrix. It is widely applicable in many fields, such as statistic analysis and system control. This task can be conducted by solving the nuclear norm regularized linear least squares model with positive semidefinite constraints. We apply the widely used alternating direction method of multipliers to solve the model and get a novel algorithm. The applicability and efficiency of the new algorithm are demonstrated in numerical experiments. Recovery results show that our algorithm is helpful.
TOTAL ENUCLEATION OF THE PROSTATE

me. Since then numerous papers: and lectures of litine lhave been published, chiefly in the JoIRNA-t and in bthe Lav1cee. In the earlier paper8 I recordedl! chniplete letails of every onie of miiy first 110 instances odf th operation. Later, as each paper dealt witlh scores and then with hundreds of cases, I lhad to confine details to special instances illustrating some novel or importatnt feature of
A Contigency Model for Requirements Development

Drawing upon the requirements and software development literature, the present study proposes an integrative contingency model for requirements development. Based on 116 quality journal articles, we analyze requirements development risks, requirements development techniques, and heuristics for how they are effectively related. Subsequently, we synthesize the insights from the identified literature into a model for requirements development that relates patterns of risk resolution to archetypical risk profiles. The model integrates the literature on requirements and software development; sets the scene for future research; and, finally proposes how practitioners can manage risks in requirements development projects.
Tissue- and Species-Specific Expression of Inhibitory Guanine Nucleotide-Binding Proteins Cloning of a Full-Length Complementary DNA From Canine Heart

Three different isoforms of the inhibitory guanine nucleotide-binding protein α-subunit (GIα) have been cloned. However, little information on the cardiac-specific expression of these isoforms is available. The deduced amino acid sequence of a full-length GIα2 complementary DNA from a canine ventricular library displays several unique residues compared with those from other species. In contrast to previously described complementary DNA clones for GIα2 this complementary DNA has a complete 3'-untranslated region with the expected consensus sequence for polyadenylation. GIα2 is the predominant isoform in the heart, and its message level of 14.7 ± 4.9 pg/10 μg total ventricular RNA is about fourfold lower than that of the stimulatory guanine nucleotide-binding protein.
Genes encoding the phycobilisome rod substructure are clustered on the Anabaena chromosome: characterization of the phycoerythrocyanin operon

The phycoerythrocyanin (pec) operon, cloned from Anabaena sp. strain PCC 7120, encodes four genes, pecBACE, located upstream of the C-phycocyanin (cpc) operon. This pec-cpc cluster includes all the genes for the structural components of the phycobilisome rod. Oligonucleotide probes based on the amino-terminal sequence of the phycoerythrocyanin beta subunit were used to clone an 8.0-kbp EcoRI fragment which was determined, by sequencing, to partially overlap the previously cloned cpc operon. A 5.0-kbp EcoRI-ClaI fragment corresponding to the region upstream of the cpc operon was subsequently subcloned and sequenced. Five open reading frames whose polarity of transcription is parallel to that of the cpc genes were identified. pecB and pecA encode the beta and alpha subunits of phycoerythrocyanin, respectively. pecC encodes the phycoerythrocyanin-associated linker polypeptide LR34.5,PEC. The identities of these genes are confirmed by agreement with amino-terminal sequences determined from purified phycobilisome components. A gene homologous to cpcE, found downstream of pecC, has been designated pecE. The cpcE gene product is involved in the attachment of the phycocyanobilin chromophore to the alpha subunit of phycocyanin. Three transcripts were observed by Northern (RNA) analyses. The most abundant of these transcripts, 1.35 kbp, corresponds to the beta and alpha subunit genes, whereas the less-abundant transcripts, 2.3 and 3.1 kbp, correspond to pecBAC and pecBACE, respectively. Phycoerythrocyanin is strongly induced in cells cultured under low light. In parallel, all three transcripts were present at much higher levels in cells cultured under low light.
An information theoretic framework for predictive channel reservation in VoIP over GPRS

The wireless telecommunication industry is now slowly shifting its paradigm from traditional, circuit‐switched, voice‐alone domain to an integrated packet‐switched architecture. This will give rise to a variety of new applications, in the same infrastructure, in a cost‐efficient way. However, due to the delay and dilemma behind new 3G mobile applications, it is important to use the legacy 2.5G access systems as much as possible, to make the transition smooth. The recent industry‐wide trend towards push‐to‐talk voice services in GPRS networks is a direct consequence of this emerging packet‐switch services. In this paper, we propose a packet‐switched‐based architectural framework for efficient integrated push‐to‐talk voice (or VoIP) and data services in GPRS using low‐bit‐rate coding. The prime novelty and advantage of the framework lies in proposing new intelligent, advanced channel reservation techniques to reduce the voice‐packet delay. Subsequent use of packet‐classification and packet assembly scheme aids in reducing the packet overhead and achieving the voice quality within ITU's recommendations. The mutual effects of data and voice packets over the entire system is analysed using suitable, two‐stage performance modelling. It has also been shown that, for voice over IP (VoIP) services, our proposed framework results in more than 50% capacity gain over current GSM system using a silent‐detection mechanism. Copyright © 2006 John Wiley & Sons, Ltd.
Targeting endoplasmic reticulum acetylation to restore proteostasis in Alzheimer's disease.

This scientific commentary refers to ‘Improved proteostasis in the secretory pathway rescues Alzheimer’s disease in the mouse’, by Peng et al. (doi:10.1093/brain/awv385). Maintaining the health of the proteome is essential for sustaining biological functions. The buffering capacity of the proteostasis network is reduced during ageing, which represents the major risk factor for most common neurodegenerative diseases. In fact, independent of the aetiology of the disease, the misfolding and aggregation of specific proteins is a hallmark of many neurodegenerative conditions, which are now classified as protein misfolding disorders. Quality control pathways recognize aberrant proteins and promote their clearance by different routes, in particular the ubiquitin–proteasome system and macroautophagy (hereafter referred to as autophagy) (Vilchez et al. , 2014). The endoplasmic reticulum (ER) is the subcellular compartment responsible for protein synthesis and folding of nearly one-third of the total proteome. Several homeostatic mechanisms control the fidelity and efficiency of the protein folding process at the ER, including the unfolded protein response (UPR), the ER-associated degradation (ERAD) pathway, and the calnexin and calreticulin cycle, among others. Recently, new post-translational modifications of ER clients were discovered in the form of acetylation of lysines, an event that serves as quality control of protein-folding intermediaries. In this issue of Brain , Peng and co-workers report that inhibiting the acetylation of nascent proteins can control ER proteostasis through a novel mechanism that modulates autophagy, providing neuroprotection in models of Alzheimer’s disease (Peng et al. , 2016). Maintaining the efficiency of the protein-folding process in the ER represents a constant challenge for the cell, where proteins with several hydrophobic transmembrane domains are folded with low rates of success. Furthermore, most secretory proteins undergo sequential post-translational modifications including glycosylation, disulfide bond formation, glycophosphatidylinositol (GPI) tagging, and proteolytic processing, in addition to the assembly of multimeric …
ADS-J1 Inhibits Semen-Derived Amyloid Fibril Formation and Blocks Fibril-Mediated Enhancement of HIV-1 Infection

ABSTRACT Semen-derived enhancer of viral infection (SEVI) is composed of amyloid fibrils that can greatly enhance HIV-1 infectivity. By its cationic property, SEVI promotes viral sexual transmission by facilitating the attachment and internalization of HIV-1 to target cells. Therefore, semen-derived amyloid fibrils are potential targets for microbicide design. ADS-J1 is an anionic HIV-1 entry inhibitor. In this study, we explored an additional function of ADS-J1: inhibition of SEVI fibril formation and blockage of SEVI-mediated enhancement of viral infection. We found that ADS-J1 bound to an amyloidogenic peptide fragment (PAP248–286, comprising amino acids 248 to 286 of the enzyme prostatic acid phosphatase), thereby inhibiting peptide assembly into amyloid fibrils. In addition, ADS-J1 binds to mature amyloid fibrils and antagonizes fibril-mediated enhancement of viral infection. Unlike cellulose sulfate, a polyanion that failed in clinical trial to prevent HIV-1 sexual transmission, ADS-J1 shows no ability to facilitate fibril formation. More importantly, the combination of ADS-J1 with several antiretroviral drugs exhibited synergistic effects against HIV-1 infection in semen, with little cytotoxicity to vaginal epithelial cells. Our results suggest that ADS-J1 or a derivative may be incorporated into a combination microbicide for prevention of the sexual transmission of HIV-1.
Laser emission from the transition-metal compound LiSrCrF6.

We have demonstrated laser action in the transition-metal compound LiSrCrF6. A Ti:sapphire laser was employed to pump into the long-wavelength absorption wing in order to mimic the AlGaAs laser-diode wavelengths. Slope efficiencies greater than 30% were measured with a crystal having passive losses of the order of 3–5%/cm.
Single image super resolution with guided back-projection and LoG sharpening

Single image super resolution requires approximation of high frequency information that was not captured in the available low resolution image. The process may result in an image that differs significantly from the original scene if no constraints are imposed. Iterative back-projection is one method used to guide the resolution enhancement process. This paper augments the iterative back-projection with edge sharpening of the error image and guided filtering to improve the high frequency content of the image. The algorithm is tested on 27 RGB colour images including the 24 images from the Kodak lossless true colour image set. The results are compared to those obtained using bicubic interpolation, wavelet zero padding and the established edge guided method. In the average results from the 27 images, the proposed method is observed to have an improvement of 0.9% over bicubic interpolation, 5.8% over wavelet zero padding and 7.5% over new edge directed Interpolation in terms of peak signal to noise ratio. The corresponding improvement in terms of structural similarity index are 1.1%, 3% and 6.8% respectively. In addition, the proposed method has the effect of suppressing spurious colours in the enhanced image.
42 CFR Part 84: Respiratory Protective Devices Implications for Tuberculosis Protection

This final rule was made available to the public at the Government Printing Office in Washington, DC, on June 2, 1995. It was published in the Federal Register on June 8, 1995, in Part II of that issue (60 FR 110:30336). This rule addresses the National Institute for Occupational Safety and Health (NIOSH) and Department of Labor/Mine Safety and Health Administration (MSHA) certification requirements for respiratory protective devices. Specifically, the rule replaces MSHA regulations at 30 CFR Part 11 with new public health regulations at 42 CFR Part 84, while also upgrading testing requirements for particulate filters. Concurrent with NIOSH publication of this new rule, MSHA published a final rule to remove existing regulations at 30 CFR Part 11, which are made obsolete by this final rule. NIOSH now will have exclusive authority for testing and certification of respirators with the exception of certain mine emergency devices, which will continue to be jointly certified by NIOSH and MSHA.