Miracle-dz/UniFAR-FTUs huggingface dataset:
using cut-offs? A systematic review

c c e p t t i c c e p r t i l This article copyright. All rights reserved. Abstract Is it possible to make diagnosis raw, and systematic review Background . The diagnosis of IgE-mediated egg allergy lies both on a compatible clinical history and on the results of skin prick tests (SPTs) and IgEs levels. Both tests have good sensitivity but low specificity. For this reason, oral food challenge (OFC) is the ultimate gold standard for the diagnosis. The aim of the present paper is to systematically review the literature in order to identify, analyze and synthesize the predictive value of SPT and specific IgEs both to egg white and main egg allergens and to review the cut-offs suggested in the literature. Methods . A total of 37 articles were included in this systematic review. Studies were grouped according to degree of cooking of the egg used for OFC, age and type of allergen used to perform the allergy work-up. Results . In children < 2 years, raw egg allergy seems very likely when SPTs with egg white extract are ≥ 4 mm or specific IgEs are ≥ 1.7 kU A /L. In children ≥ 2 years, OFC could be avoided when SPTs with egg white extract are ≥ 10 mm or Prick by Prick with egg white are ≥ 14 mm or specific IgE are ≥ 7.3 kU A /L. Likewise, heated egg allergy can be diagnosed if SPTs with egg white extract are > 5 mm and > 11 mm in children < 2 years and ≥ 2 years, respectively. Conclusions . Further and better-designed studies are needed to determine the remaining diagnostic cut-off of specific IgE and SPT for heated and baked egg allergy. of 5.2 kU A /L for OVM as predictive of an allergic reaction to raw egg, with a 95% PPV (52). This study unclear risk of bias for and timing.
V Region Gene to Glucuronoxylomannan of of Monoclonal Antibodies That Use the Same Unexpected Diversity in the Fine Specificity

Most mAbs to the capsular polysaccharide glucuronoxylomannan (GXM) of Cryptococcus neoformans are generated from the same V H and V L gene families. Prior Ab studies have assessed protective efﬁcacy, Id structure and binding to capsular polysaccharides, and peptide mimetics. These data have been interpreted as indicating that most mAbs to GXM have the same speciﬁcity. A new approach to Ab speciﬁcity analysis was investigated that uses genetic manipulation to generate C. neoformans variants with structurally different capsules. C. neoformans mutants expressing GXM with defective O -acetylation were isolated and complemented by the C. neoformans gene CAS1 , which is necessary for the O -acetylation of GXM. The mAbs exhibited differences in their binding to the GXM from these mutant strains, indicating previously unsuspected differences in speciﬁcity. Analysis of three closely related IgMs revealed that one (mAb 12A1) bound to an epitope that did not require O -acetylation, another (mAb 21D2) was inhibited by O -acetylation, and the third (mAb 13F1) recognized an O -acetylation-dependent conformational epitope. Fur-thermore, an IgG Ab (mAb 18B7) in clinical development retained binding to de- O -acetylated polysaccharide; however, greater binding was observed to O -acetylated GXM. Our ﬁndings suggest that microbial genetic techniques can provide a new approach for epitope mapping of polysaccharide-binding Abs and suggest that this method may applicable for studying the antigenic complexity of polysaccharide Ags in other capsulated microorganisms. The Journal of Immunology, 2004, 172: 3670–3677.
GSyellow , a Multifaceted Tag for Functional Protein Analysis in 11 Monocot and Dicot Plants

13 Nienke Besbrugge2, Jelle Van Leene2, Dominique Eeckhout, Bernard Cannoot, 14 Shubhada R. Kulkarni, Nancy De Winne, Geert Persiau, Eveline Van De Slijke, 15 Michiel Bontinck, Stijn Aesaert, Francis Impens, Kris Gevaert, Daniel Van 16 Damme, Mieke Van Lijsebettens, Dirk Inzé, Klaas Vandepoele, Hilde Nelissen3, 17 and Geert De Jaeger3* 18 19 Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium (N.B., D.E., B.C., S.R.K., N.D.W., G.P., E.V.D.S., M.B., S.A., D.V.D., M.V.L., D.I., K.V., H.N., J.V.L., G.D.J.); VIB Center for Plant Systems Biology, 9052 Ghent, Belgium (N.B., D.E., B.C., S.R.K., N.D.W., G.P., E.V.D.S., M.B., D.V.D., M.V.L., D.I., K.V., H.N., J.V.L., G.D.J.); Bioinformatics Institute Ghent, Ghent University, 9052 Ghent, Belgium (S.R.K., K.V.); Department of Biochemistry, Ghent University, 9000 Ghent, Belgium (F.I., K.G.); VIB Center for Medical Biotechnology, 9000 Ghent, Belgium (F.I., K.G.); and VIB Proteomics Core, 9000 Ghent, Belgium (F.I.) 20 ORCID IDs: 0000-0001-8565-3403 (N.B.); 0000-0001-5770-7670 (D.E.); 0000-000121 9982-0890 (B.C.); 0000-0003-2290-8004 (S.R.K.); 0000-0003-3735-3152 (N.D.W.); 22 0000-0003-2240-4527 (G.P.); 0000-0003-2247-2976 (E.V.D.S.); 0000-0001-661423 Plant Physiology Preview. Published on April 20, 2018, as DOI:10.1104/pp.18. 00175
Women in Engineering: Promoting Identity Exploration and Professional Development

development of self-concept/identity/professional development in college for and maltreatment/foster care in economically, linguistically, and culturally diverse samples. Abstract Engineering colleges are concerned about retention of women, especially women of color, in their programs. One possible solution is to promote undergraduate women’s engineering identity. This paper describes an evaluation of a one-day technical and professional development conference for undergraduate women in engineering and computer science, which focused on understanding and facilitating engineering identity. Data on the impact of the conference and engineering identity, were collected in pre- and post-conference surveys. The pre-conference survey assessed demographic information (e.g., first generation status, ethnicity), engineering student identity (i.e., commitment to engineering major; engineering competence, and engineering agency), social support, and reasons for attending. The post-conference survey assessed engineering student identity, ratings of self- and “engineer” creativity, professional identity, and evaluations of the conference. 193 participants returned pre-conference surveys and 103 returned post-conference surveys. Most were engineering (54%) and computer science (38%) majors; 46% were Asian, 28% LatinX; and 65% received financial aid. Correlations, MANOVA, regression, and content analyses were used to analyze the data. and Results the strength knowing an also indicated that women do being as creative as and strong association between self-ratings creativity and identity. participants’ reported conference and its Suggestions for promoting engineering identity are described.
Quadratic, Affine and Hybrid Gaussian Term Structure Models in Discrete Time: Theory and Evidence

This paper explores Affine, Quadratic and Hybrid Term Structure Models in discrete time. Hybrid specification joints ATSM and QTSM with correlated Gaussian state variables. We provide new formulae and a new estimation strategy that make these models implementable. We estimate and extract latent factors of nine specifications (Affine, Quadratic and Hybrid Gaussian types). We analyze the behavior of each model, their capacity to fit moments of data and to reproduce the yield curves shapes. Our empirical results suggest first that Hybrid models with less than two quadratic factors are not worth considering. Second, three-factor Hybrid models have to be favored over ATSMs or QTSMs. Third, all models tend to have similar performance as the number of state factors increases. Fourth, given a number of state factors, Affine, Quadratic or Hybrid models have state factors that vehicle similar information about the level, the slope and the curvature of the yield curve. As an exception, three-factor model Hybrid specifications do not exhibit curvature effect. Finally, only three-factor models have their dynamic performance structurally uncorrelated to the level, the slope and the curvature. However, no model can absorb corresponding huge squared first-order variations.
Toxicity assessment and prediction of a realistic pesticide mixture from a Portuguese agricultural area using concentration-response surface statistics

Orientador(es): Doutora Emília Cardoso Moura da Silva Professora Doutora Maria José Antão Pais de Almeida Cerejeira Júri: Presidente: Professora Doutora Elizabeth da Costa Neves Fernandes de Almeida Duarte, Professora Catedrática Aposentada do Instituto Superior de Agronomia da Universidade de Lisboa, Vogais: Doutora Emília Cardoso Moura da Silva, Técnica Superior do Instituto Superior de Agronomia da Universidade de Lisboa, Doutor Michiel Adriaan Daam, Bolseiro de Pós-Doutoramento da Fundação para Ciência e a Tecnologia.
NDT_A_275796 2397..2406

Department of Psychiatry, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea Purpose: We aimed to compare the Korean version of the ADHD Rating Scale (K-ARS) and Integrated Visual and Auditory Plus (IVA+Plus), a continuous performance test, by analyzing their abilities to distinguish different groups (attention-deficit/hyperactivity disorder [ADHD], ADHD-not otherwise specified [NOS], and normal control [NC]). Patients and Methods: Individuals of 7–12 years of age who visited our child and adolescent psychiatric clinic were recruited. Seventy-four participants (58 males, 16 females) were classified into three groups according to results from the Korean Version of Diagnostic Interview Schedule for Children Version IV. The K-ARS and IVA+Plus were administered. An analysis of covariance (ANCOVA) was conducted. The tools’ accuracy in discriminating patients with ADHD or NOS from NCs was evaluated using a receiver operating characteristic (ROC) curve analysis. Results: ANCOVA revealed significant differences in the K-ARS results of the three groups (ADHD [n=29], NOS [n=33], NC [n=12]), whereas a difference in IVA+Plus results was observed only between the ADHD and NC groups. In the ROC curve analysis of the K-ARS, the areas under the curve (AUCs) for each group were 0.960 (ADHD vs NC), 0.885 (NOS vs NC), 0.920 (ADHD+NOS vs NC), and 0.779 (ADHD vs NOS+NC). In the ROC curve analysis for the IVA+Plus hyperactivity-impulsiveness scale, the AUCs for each group were 0.740 (ADHD vs NC), 0.643 (NOS vs NC), 0.688 (ADHD+NOS vs NC), and 0.626 (ADHD vs NOS+NC); those for the inattention scale were 0.731 (ADHD vs NC), 0.658 (NOS vs NC), 0.692 (ADHD+NOS vs NC), and 0.625 (ADHD+NOS vs NC). Conclusion: The K-ARS was useful to distinguish the ADHD and NOS groups from the NC group, while the IVA+Plus was useful to distinguish the ADHD group from the NC group. Clinicians should ensure they understand the properties of each tool and apply them appropriately in the diagnosis of ADHD.
LIPID PROFILE OF ADULT WOMEN AND ITS RELATION WITH CENTRAL ADIPOSITY

Objective: To access the lipid profile of adult women and to evaluate its relationship with anthropometric measures concerning the central adiposity. Methods: Cross-sectional study, conducted in a clinical school of nutrition at a public university in Minas Gerais, comprising 47 adult women who were on the waiting list for the service. The concentrations of total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), triglycerides (TG), and weight, height, waist circumference (WC) and hip circumference (HC) were evaluated. The body mass index (BMI) and waist-hip ratio (WHR) were calculated. Analysis of the association of serum lipids to adiposity variables occurred through the Pearson correlation coefficient. Results: Of the volunteers, 22 (51.2%) had TC levels above the borderline values and 18 (41.9%) had high LDL. The proportion of subjects with elevated VLDL and TG levels was relatively low (n=4; 9.3% and n=10; 23.3%, respectively). The WC and WHR were positively correlated with the VLDL and TG levels (p <0.05). Among volunteers with BMI ≥ 25 kg/m², the prevalence of dyslipidemia was 39.5% (n=17) and WC was positively correlated with TC levels (p = 0.04). Conclusion: Results pointed out an association of serum lipids to the measures of central adiposity, with important frequencies of dyslipidemia in the women under investigation, especially high levels of TC and LDL. ≥ 25 kg/m², la prevalencia de dislipidemias fue del 39,5% (n=17) y la CC se correlacionó positivamente con los niveles de CT (p = 0,04). Conclusión: Los resultados señalaron relación de los lípidos séricos y las medidas de adiposidad central con frecuencias importantes de dislipidemias en las mujeres investigadas, especialmente niveles elevados de CT y LDL.
Selecting the Working Correlation Structure by a New Generalized AIC Index for Longitudinal Data

The analysis of longitudinal data has been a popular subject for the recent years. The growth of the Generalized Estimating Equation (GEE) Liang & Zeger, 1986) is one of the most influential recent developments in statistical practice for this practice. GEE methods are attractive both from a theoretical and a practical standpoint. In this paper, we are interested in the influence of different “working” correlation structures for modeling the longitudinal data. Furthermore, we propose a new AIC-like method for the model assessment which generalized AIC from the point of view of the data generating. By comparing the difference of the log-likelihood functions between different correlation models, we define the exact n~ value to create an interval for our model selection. In this thesis, we combine the GEE method and a new generalized AIC Index for the longitudinal data with different correlation structures. INDEX WORDS: Longitudinal data, Generalized Estimating Equation, Working Correlation, Generalized AIC Index SELECTING THE WORKING CORRELATION STRUCTURE BY A NEW GENERALIZED AIC INDEX FOR LONGITUDINAL DATA
Key Beliefs Underlying Students’ Behaviour and Decisions towards HIV/AIDS: Implications for Educational Interventions

Education programmes towards HIV/AIDS prevention are still considered important in response to the epidemic. The study sought to determine key beliefs underlying students’ decisions and behavior towards HIV/AIDS. Beliefs are so pervasive that it merits consideration in behavioral interventions, especially among audiences who are exposed daily to its socializing influences in Ghana. This paper reports on the qualitative approach of a mixed method study involving Junior High School students in Obuasi, Ghana. Data was collected from three sets each of boys, girls and mixed groups’ focus groups and teachers’ interviews and analysed using thematic technique. The value-expectancy theory served as theoretical framework explaining individual‘s strength of motivation to strive for a certain goal to the expectations to attain the desired goal and the incentive value of that particular goal. The conclusions posit a preference for the promotion of abstinence and a dislike for condom promotion to curb the HIV incidence despite perceived prevailing sexual activities among students. The motivations towards abstinence was generally explained within value-based and futuristic expectation framework: pleasing God for blessings, pleasing family to gain respect and social approval, keeping virginity, avoiding negative consequence, and pursuing education for better future and marriage. The findings suggest, values may represent important protective factor: adolescents who strongly identify with such position may less likely engage in HIV risk-related behaviors. A threat to comprehensive HIV education was however, observed due to lack of self-efficacy and apathy towards sex and condoms education influenced significantly by respondent’ beliefs and sensitivity to cultural issues.
A Time-Domain Based Lossless Data Compression Technique for Wireless Wearable Biometric Devices

—This paper presents a promising lossless compression technique called Log2 Sub-band encoding, which is suitable for implementing on wireless wearable biometric devices. Data compression promises a power saving from the transceiver during the data transmission and further extends battery lifetime on a device. The performance of this technique is measured in term of compression ratio (CR). Our simulations suggest a CR that is comparable, and indeed superior to the combination of Differential pulse-code modulation (DPCM) and Huffman coding, whilst using minimal hardware. The simulations primarily use electroencephalogram (EEG) data, and a estimated power saving is given whilst the implementation issues and possible inﬂuence of different biomedical data on technique (cid:48) s performance will also be considered.
and Sensitization Acts as a Master Switch between Tolerance Danger Signaling through the Inflammasome

Efﬁcient priming of adaptive immunity depends on danger signals provided by innate immune pathways. As an example, inﬂam-masome-mediated activation of caspase-1 and IL-1 (cid:1) is crucial for the development of reactive T cells targeting sensitizers like dinitroﬂuorobenzene (DNFB). Surprisingly, DNFB and dinitrothiocyanobenzene provide cross-reactive Ags yet drive opposing, sensitizing vs tolerizing, T cell responses. In this study, we show that, in mice, inﬂammasome-signaling levels can be modulated to turn dinitrothiocyanobenzene into a sensitizer and DNFB into a tolerizer, and that it correlates with the IL-6 and IL-12 secretion levels, affecting Th1, Th17, and regulatory T cell development. Hence, our data provide the ﬁrst evidence that the inﬂammasome can deﬁne the type of adaptive immune response elicited by an Ag, and hint at new strategies to modulate T cell responses in vivo. The Journal of Immunology, 2008, 180: 5826–5832.
(2004) 'Movie Recommendation Systems Using An Artificial Immune System'. In: 6th International Conference in Adaptive Computing in Design and Manufacture, 2004, Bristol

We apply the Artificial Immune System (AIS) technology to the Collaborative Filtering (CF) technology when we build the movie recommendation system. Two different affinity measure algorithms of AIS, Kendall tau and Weighted Kappa, are used to calculate the correlation coefficients for this movie recommendation system. From the testing we think that Weighted Kappa is more suitable than Kendall tau for movie problems.
LymphocytesAdhesion Molecules on Human T Redistribution of Antigen Recognition and Lipid Microdomain Clustering Induces a

The study of lipid microdomains in the plasma membrane is a topic of recent interest in leukocyte biology. Many T cell activation and signaling molecules are found to be associated with lipid microdomains and have been implicated in normal T cell function. It has been proposed that lipid microdomains with their associated molecules move by lateral diffusion to areas of cellular interactions to initiate signaling pathways. Using sucrose density gradients we have found that human T cell (cid:1) 1 integrins are not normally associated with lipid microdomains. However, cross-linking of GM1 through cholera toxin B-subunit (CTB) causes an enrichment of (cid:1) 1 integrins in microdomain fractions, suggesting that cross-linking lipid microdomains causes a reorganization of molecular associations. Fluorescent microscopy was used to examine the localization of various lymphocyte surface molecules before and after lipid microdomain cross-linking. Lymphocytes treated with FITC-CTB reveal an endocytic vesicle that is enriched in TCR and CD59, while (cid:1) 1 integrin, CD43, and LFA-3 were not localized in the vesicle. However, when anti-CTB Abs are used to cross-link lipid microdomains, the microdomains are not internalized but are clustered on the cell surface. In this study, CD59, CD43, and (cid:1) 1 integrin are all seen to colocalize in a new lipid microdomain from which LFA-3 remains excluded and the TCR is now dissociated. These ﬁndings show that cross-linking lipid microdomains can cause a dynamic rearrangement of the normal order of T lymphocyte microdomains into an organization where novel associations are created and signaling pathways may be initiated. The Journal of Immunology, 2002, 168: 2737–2744.
Inhibition of CD4 T Cell Function Concanavalin A-Induced Hepatitis via the Apolipoprotein A-II Suppressed

Con A-induced hepatitis has been used as a model of human autoimmune or viral hepatitis. During the process of identifying im-munologically bioactive proteins in human plasma, we found that apolipoprotein A-II (ApoA-II), the second major apolipoprotein of high-density lipoprotein, inhibited the production of IFN- g by Con A-stimulated mouse and human CD4 T cells. Con A-induced hepatitis was attenuated by the administration of ApoA-II. The beneﬁcial effect of ApoA-II was associated with reduced leukocyte inﬁltration and decreased production of T cell-related cytokines and chemokines in the liver. ApoA-II inhibited the Con A-induced activation of ERK–MAPK and nuclear translocation of NFAT in CD4 T cells. Interestingly, exacerbated hepatitis was observed in ApoA-II–deﬁcient mice, indicating that ApoA-II plays a suppressive role in Con A-induced hepatitis under physiological conditions. Moreover, the administration of ApoA-II after the onset of Con A-induced hepatitis was sufﬁcient to suppress disease. Thus, the therapeutic effect of ApoA-II could be useful for patients with CD4 T cell-related autoimmune and viral hepatitis. The Journal of Immunology , 2011, 186: 3410–3420.
Application of Voronoi tessellations to model cellular aerogels

Many aerogels are characterized by a ﬁbrillar morphology. Recently proposed constitutive models have shown good predictive capabilities in describing the mechanical behavior of such aerogels. On the one hand, these models account for the cellular nature and adhere to the cell-size distributions, while on the other hand they are based on the assumption of the network made up of idealized square-shaped cells. The heterogeneous cellular morphology of aerogels can computationally be described by a Voronoi tessellation- based approach. Accordingly, the random cell shapes within the network are accounted for by means of the pore-size distribution data obtained from experiments. To this end, 2-d and 3-d periodic representative volume elements (RVEs) are generated from the cellular structure obtained using Voronoi tessellations and simulated under compression using ﬁnite element analysis.
Lessons Learned from Research through Design An empirical research towards practical guidelines for Research through Design

Research through Design entails the generation of research insights by performing a design exercise. In literature, Research through Design has not quite taken shape as a methodology that supports its practical use. Therefore, literature provides little practical guidance to conduct a research led by this approach. To ﬁll this knowledge gap, this article identiﬁes three lessons learned that can serve as practical guidelines to support a Research through Design led research. These lessons learned are formulated based on the analysis of a research project on ﬁve methodological aspects of Research through Design which are found in literature. Further research can be conducted by applying these lessons learned to future researches and test their supportive contribution to the progress of the research.
Long-Term Follow-Up of Hepatitis B e Antigen-Negative Hepatitis B Virus Carriers according to the Status of HBV DNA and ALT Levels Fumio International Journal of Hepatology & Gastroenterology

Cite this article: Imazeki F, Arai M, Kanda T, Mikata R, Nakamoto S, et al. Long-Term Follow-Up of Hepatitis B e Antigen-Negative Hepatitis B Virus Carriers according to the Status of HBV DNA and ALT Levels. Int J Hepatol Gastroenterol. 2018; 4(1): 017-023. cirrhosis, hepatitis ﬂ are- up, HBcrAg, AST, G-GTP, AFP, HBV DNA levels and platelet counts. Two patients died during follow-up, 1 of gastrointestinal bleeding and the other of HCC. Among 68 patients in group A, none developed hepatitis ﬂ are-up deﬁ ned as ALT >80 IU/L and HBV DNA ≥4LC/ml. Conclusions: HBeAg-negative carriers with HBV DNA<4 LC/ml and ALT≤30 during the ﬁ rst year of follow-up showed favorable prognosis if inactive cirrhosis could be excluded.