Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Aerobic Exercise on Thyroid Hormones and Quality of Life in Obese Postmenopausal Women

Background and objectives: Studies have shown that exercise can affect hormone secretion and some metabolic and endocrine functions. The aim of this study was to assess the effect of eight weeks of aerobic training on thyroid hormones and quality of life in obese postmenopausal women. Methods: In this semi-experimental study, 21 obese (body mass index >30 Kg/m2) women aged between 35 and 45 were randomly divided into an experimental (n=10) group and a control group (n=11). The subjects in the experimental group performed 30-60 minutes of aerobic exercise at 65-75% of maximum heart rate, three times a week, for eight weeks. Level of thyroid hormones and quality of life subscales were compared within and between the groups. Statistical analysis was performed at significance level of 0.05. Results: After the eight-week exercise program, thyroxine, triiodothyronine and thyrotropin releasing hormone levels increased significantly, and thyroid releasing hormone level decreased significantly (P=0.001). The exercise program also had significantly positive effects on quality of life and its occupational, sexual and emotional subscales in obese postmenopausal women. Conclusion: Aerobic exercise causes a significant increase in levels of thyroxine, triiodothyronine and thyrotropin releasing hormone and some subscales of quality of life. It also causes a significant decrease in thyroid releasing hormone level, which indicates the effect of exercise on hormone secretion.
The effect of transplantation of bone marrow cells induced by the contact with thymus-derived multipotent stromal cells on the immune system of mice, regenerating after cyclophosphamide treatment

The effect of transplantation of syngeneic bone marrow cells (BMCs) after their contact in vitro with thymus-derived multipotent stromal cells (MSCs) for regeneration of damaged by cyclophosphamide immune system of mice was studied.Materials and methods. MSCs were obtained from C57BL/6 mice’s thymus by explants method. BMCs were obtained by flushing the femurs. BMCs were induced for 2 hours on the monolayer of thymus-derived MSCs. The immune deficiency of mice was modelled using cyclophosphamide injection. After that, cell transplantation was performed and the state of the immune system was assessed. The number of erythrocytes, hematocrit, hemoglobin concentration in the peripheral blood; the phases of the cell cycle and apoptosis of mesenteric lymph node cells were determined. The amount of antibody-producing cells in the spleen and the delayed hypersensitivity response was determined. The study of proliferative and cytotoxic activity of natural killer lymphocytes, the analysis of phagocytosis, spontaneous and induced bactericidal activity of peritoneal macrophages were performed.Results. It was shown that unlike intact bone marrow cells, BMCs induced by thymus-derived MSCs provided increased spontaneous proliferative activity of lymphocytes with a decrease in the number of lymph node cells in G0/G1 phase by 6.2 % and an increase the number of lymphocytes in S+G2/M phase by 28 % in comparison with the group of mice treated with cyclophosphamide, as well as the recovery of cellularity of the bone marrow, lymph nodes and spleen. At the same time in the lymph nodes, the number of cells in the apoptosis increased. BMCs induced by MSCs showed a pronounced negative effect on natural cytotoxicity, reducing its rates by 3 times compared with the group of cyclophosphamide-treated mice, and on adaptive immunity: the rates of delayed hypersensitivity response decreased by 1.7 times, number of antibody-producing cells by 1.8 times. Red blood cell regeneration was stimulated by intact BMCs, which was manifested by the normalization of hematocrit and hemoglobin and an increase in the number of reticulocytes in the blood by 2.2 times compared with the group of mice treated with cyclophosphamide.Conclusion. Transplanted BMCs improve erythropoiesis in mice after cyclophosphamide treatment, and BMCs, previously induced by thymus-derived MSCs, lose this ability. BMCs after co-culture are strongly activated to impact on the immune system, which is most likely due to the effect of contact interaction with thymus-derived MSCs, which is known, effectively affect hematopoietic cells and possess immunomodulatory properties.
Comparison of Cardiovascular Fitness in Home School and Public School Children

Neuville AL, Mohr CE, Pierquet MF Comparison of Cardiovascular Fitness in Home School and Public School Children. Journal of Undergraduate Kinesiology Research. 2006; 2(1):32-40. Purpose: The purpose of this study was to compare the difference in cardiovascular fitness between home school and public school children by using the mile run. Methods: Twenty six healthy subjects (14 boys, 12 girls) ages 10-14 years participated in the mile run. Each participant was asked to run or walk the mile giving their greatest effort. There were significant differences (P 0.05) in VO2 max levels between home school and public school children. Results: The home school children’s mean VO2 max was 48.7 ml*kg*min and the public school children’s mean VO2 max was 42.2 ml*kg *min. The mean mile run time for the home school students was 9.0 minutes and 11.3 minutes for the public school students. Conclusion: The findings in our study are significant to physical educators and parents with middle school children. These findings suggest that home school children are aerobically fit than public school children.
The Main Causes of Thrombotic Events in Carriage of Leiden Mutation in Women of Reproductive Age

The article defines the role of a combination of several acquired thrombogenic risk factors with Activated Protein C (APC) resistance which is due to carriage of FVL (1691)GA genotype to develop Venous Thromboembolic Complications (VTEC). In this regard, a prospective clinical study of 1100 women of reproductive age was conducted. The patients were divided into two groups. The main group–500 patients with FVL (1691)GA genotype, and the control group–600 women with FVL(1691)GG genotype. Based on the findings of the conducted study, it was concluded that carriage of FVL (1691)GA genotype is associated with VTEC development compared to the normozygous genotype. The highest incidence of primary thrombotic events was identified on the background of combined hormonal contraceptive administration. In the event of VTEC, carriers of Factor V Leiden (FVL (1691)GA) mutation often suffer from hypertensive disorders, varicose disease of the lower extremities, overweight and/or combinations of these pathology types. It was defined that in all cases of thrombosis episode, the value of APC resistance was ≤ 0.49 according to Normalized Ratio (NR), while episodes of VTEC were not observed in NR ≥ 0.5.
Effects of traditional Chinese exercises on insomnia after coronavirus disease 2019: A protocol of systematic review and meta-analysis

Background: There is growing evidence that coronavirus disease 2019 (COVID-19) can trigger acute episodes of insomnia. Reports on the treatment of COVID-19-related insomnia are limited. Therefore, our study aims to perform a systematic evaluation and meta-analysis of the effects of traditional Chinese exercises (TCEs) in patients with insomnia due to COVID-19. Methods: We will search the Embase, PubMed, Cochrane Library, Web of Science, MEDLINE, Scopus, Chinese Biomedical Literature Database, Chinese National Knowledge Infrastructure Database, and Wan Fang Database from December 1, 2019 to October 2, 2022 to identify all articles on treatment of COVID-19-related insomnia using TCEs. Two researchers will screen the articles and extract the relevant information. Results: The results will provide a systematic overview of the current evidence on the use of TCE to treat patients with insomnia after COVID-19. Conclusions: The conclusions of this study will help clarify the effects of TCEs on patients with insomnia after COVID-19.
Combined anterior cruciate ligament and posterolateral corner injuries: diagnosis and treatment

Combined multiligament knee injuries are more frequent than previously reported when objective diagnostic tools are utilized. Timely diagnosis of concurrent lateral sided ligamentous injuries is of vital importance because unaddressed posterolateral corner (PLC) tears are known to increase the stress on an anterior cruciate ligament (ACL) reconstruction graft and potentially increase the risks of graft failure. Additionally, improved surgical outcomes can be expected if all injured structures are addressed concurrently in the acute setting. Therefore, the purpose of this article was to review the relevant literature on the diagnosis and treatment of concomitant ACL and PLC injuries.
Pair-matched study of cryopreserved versus native graft in adult and pediatric recipients of allogeneic hematopoietic stem cell transplantation

Elena V. Babenko, Ivan S. Moiseev, Mikhail M. Kanunnikov, Alexandr L. Alyanskiy, Dmitrii E. Pevcov, Anastasia V. Frolova, Anna A. Osipova, Tatyana A. Bykova, Olesya V. Paina, Elena I. Darskaya, Ludmila S. Zubarovskaya, Sergey N. Bondarenko, Inna V. Markova, Boris V. Afanasyev R. Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, The First St. Petersburg State I. Pavlov Medical University, St. Petersburg, Russia Pair-matched study of cryopreserved versus native graft in adult and pediatric recipients of allogeneic hematopoietic stem cell transplantation Cellular Therapy and Transplantation (CTT). Vol. 7, No. 2(23), 2018 doi: 10.18620/ctt-1866-8836-2018-7-2-45-53 Submitted: 26 June 2018, accepted: 20 July 2018
Neurology

The profession of neurology has come a long way over the years. In 1664, Thomas Willis in his textbook Cerebral Anatomy described the different structures in the brain and coined the word “neurology”—a branch of medicine concerned with the structure, function, and diseases of the nervous system. Although our profession may have originated about 355 years ago, it has had more rapid advancement in the last 50 years.
The role of exercise in glycaemic control and inflammation in overweight/obese individuals with and without type 2 diabetes

Evidence suggests the chronic low-grade inflammation associated with obesity increases the risk of developing type 2 diabetes mellitus (T2DM). Increased rates of exercise participation has been shown to reduce the risk of progression from overweight/obese to T2DM. Paradoxically, exercise results in an acute inflammatory response. The purpose of the research herein was to characterize the response in key inflammatory markers and glycaemia to acute exercise and short-term training in sedentary, overweight individuals and individuals with T2DM. Glucose tolerance and the interleukin-6 (IL-6) receptor pathway were assessed following acute (1h and 25h post-exercise) continuous exercise of moderate intensity (CME), and compared with a work- and duration-matched bout of high intensity intermittent exercise (HIIE; Chapter 4). There was an improvement in glucose tolerance immediately but not 25h post-exercise, concomitant with increased activity via the IL-6 classical signalling pathway. However, there were no differences between exercise modes and no associations between glucose tolerance and IL-6 signalling markers. The response in matrix metalloproteinase (MMP)-2 and MMP-3, as well as osteopontin was assessed following acute exercise in chapter 5.Continuous glucose monitoring was performed the day prior to exercise (control), the dayof exercise, and the day after exercise and showed no between-day or condition (CME vs. HIIE) differences. However, differences in MMP-3 and osteopontin were identified in a direction consistent with protection against metabolic and cardiovascular disease. Effect of short-term exercise training (12 consecutive days of treadmill exercise) on inflammation and glucose control were assessed in previously diagnosed individuals with T2DM (Chapter 6). There were improvements in glycaemic control and global inflammation status post-training. Acute changes in pro- and anti-inflammatory cytokine responses following the first and last exercise session were also observed. The significance of these findings and future direction of research are discussed in chapter 7.
First successful breeding of reintroduced ospreys pandion haliaetus in mainland Spain

En 2003 se puso en marcha un programa de reintroduccion del aguila pescadora en la region de Andalucia, SO de Espana, con el fin de recuperar la poblacion reproductora de Espana continental y mejorar la situacion de la especie en el Mediterraneo. Entre 2003 y 2009 se soltaron 129 juveniles mediante crianza campestre. En 2009, la primera pareja reproductora crio con exito tres pollos en las marismas del Odiel, siendo esta la primera vez en Espana continental desde su extincion en 1981. Esta pareja reproductora constituye un importante indicador para la evaluacion del proyecto y el inicio de una futura poblacion
Questions about grilling.

We present taveRNA, a web server package that hosts three RNA web services: alteRNA, inteRNA and pRuNA. alteRNA is a new alternative for RNA secondary structure prediction. It is based on a dynamic programming solution that minimizes the sum of energy density and free energy of an RNA structure. inteRNA is the first RNA–RNA interaction structure prediction web service. It also employs a dynamic programming algorithm to minimize the free energy of the resulting joint structure of the two interacting RNAs. Lastly, pRuNA is an efficient database pruning service; which given a query RNA, eliminates a significant portion of an ncRNA database and returns only a few ncRNAs as potential regulators. taveRNA is available at http://compbio.cs. sfu.ca/taverna.
Role of Gender on Quality of Life and Functional Status in Stroke Patients with Urinary Incontinance

Methods: This study included 128 stroke patients (64 male, 64 female) with UI and was conducted in the inpatient and outpatient clinics of a public rehabilitation hospital in June,July, and August 2018. Patients were asked to fill a structured questionnaire for colllection of demographic data and incontinence properties, SF-36 for evaluation of quality of life, and Barthel Index for evaluation of functional capacity.
Characteristics and consequences of antenatal exposure to selective serotonin reuptake inhibitors

Depression is a common condition, affecting around one in 20 people worldwide. It is challenging conceptually and clinically, with treatment being ineffective for many, and significant consequences for individuals and societies alike. Depression is particularly problematic during pregnancy, where it is no less common, but poses additional difficulties. Both depression and its pharmacological treatments are associated with a range of short- and longer- term sequelae for offspring, and current data is insufficient to allow fully informed decisions to be made by mothers, midwives, or doctors. Research is affected by practical, ethical, and methodological issues, and a myriad of confounding factors, which combine to increase uncertainties over the risks and benefits of prescribing (or not). Retrospective and prospective observational studies accompany epidemiological data linkage and meta- analyses involving millions of subjects, in contributing to both current knowledge and testable hypotheses to inform future directions for research, while clinical and preclinical studies with smaller sample sizes provide invaluable and complementary details. However, significant gaps remain, not least in delivering optimal care to each individual mother and baby. While the overall emerging picture appears reassuring to some, others acknowledge that we do not even possess all the pieces of the puzzle yet. There remains an urgent need for more comprehensive and relevant data. This thesis presents the findings from a series of pilot studies on evaluating the characteristics and consequences of antenatal exposure to selective serotonin reuptake inhibitors. Up to one in 10 women in the general Scottish population may be exposed to an antidepressant at some point during pregnancy, but adverse outcomes may be related more to underlying maternal depression, rather than its pharmacological treatment. We highlight areas of both intelligence and ignorance, and make proposals for future research.
The Role of Brain Mechanisms in the Generation of Consciousness

This paper first reviews our present understanding, and misunderstanding, of the ‘binding’ problem of how phenomenal colour, shape, and movement are integrated within the visual system. The traditional theory that this is done by interactions between the separate colour, shape, and motion computational centres in the visual cortex has been undermined by experiments carried out by Semir Zeki that suggest that such interactions do not take place. This is linked to the hypothesis that the visual system contains two channels: (1) Ohyama’s hierarchical behavioural network and (2) the visual phenomenal network. The review presents a further linkage between the computational mechanisms (in particular information compression) used in vision with those used in digital television. Then a number of theories designed to explain how the ‘binding’ may operate are examined. Two theories have their basis within the identity theory and a third theory is based on a recent version of the psychoneural interaction theory that distinguishes phenomenal space (and its contents) from physical space (and its contents). The conclusion is made that the new formation presented in this review supports the latter theory. Correspondence: John Smythies, Center for Brain and Cognition, UCSD, San Diego, CA, USA. Email: jsmythies@ucsd.edu Website: www.johnsmythies. com C op yr ig ht ( c) Im pr in t A ca de m ic 2 01 6 F or p er so na l u se o nl y -n ot fo r re pr od uc tio n BRAIN MECHANISMS & CONSCIOUSNESS 255
The participation of hepatic Golgi apparatus in the intraceUular transport of blood-destined proteins has been analyzed using Golgi fractions enriched in c/s

The participation of hepatic Golgi apparatus in the intraceUular transport of blood-destined proteins has been analyzed using Golgi fractions enriched in c/s and trans components of the Golgi apparatus. SDS-polyacrylamide gel electrophoresis of the liver Golgi fractions showed several proteins corresponding in relative proportions and mobilities with serum proteins. After a pulse injection of labeled leucine, the secretory content of the c/s Golgi fraction was labeled earlier than the trans Golgi fraction. Taken together, the results show the participation of the liver Golgi apparatus in the secretion of most of the serum proteins and provide documentation for a sequential progression of secretory protein through the c/s and trans components of the Golgi apparatus.
Measuring Efficiency and Risk Preferences in Dynamic Portfolio Choice

This paper uses non-parametric methods to study the efficiency (Dybvig, 1988) and risk-profile (Varian, 1988) of dynamic portfolio choices. We design an experiment which varies the number of states (complexity), and includes an equivalent static Arrow-Debreu problem. The results suggest that complexity reduces efficiency, as does lower cognitive ability. Efficiency is also lower in the static problem, and in the dynamic task it is mostly driven by a form of stop-loss strategy. Further, we find that a representative agent exhibits decreasing absolute risk aversion and constant relative risk aversion, despite significant individual heterogeneity.
FlexyFont: Learning Transferring Rules for Flexible Typeface Synthesis

Maintaining consistent styles across glyphs is an arduous task in typeface design. In this work we introduce FlexyFont, a flexible tool for synthesizing a complete typeface that has a consistent style with a given small set of glyphs. Motivated by a key fact that typeface designers often maintain a library of glyph parts to achieve a consistent typeface, we intend to learn part consistency between glyphs of different characters across typefaces. We take a part assembling approach by firstly decomposing the given glyphs into semantic parts and then assembling them according to learned sets of transferring rules to reconstruct the missing glyphs. To maintain style consistency, we represent the style of a font as a vector of pairwise part similarities. By learning a distribution over these feature vectors, we are able to predict the style of a novel typeface given only a few examples. We utilize a popular machine learning method as well as retrieval‐based methods to quantitatively assess the performance of our feature vector, resulting in favorable results. We also present an intuitive interface that allows users to interactively create novel typefaces with ease. The synthesized fonts can be directly used in real‐world design.
Lokomat: Automated electromechanical gait training in neurological patients

Neurological disorders such as stroke and (incomplete) spinal cord injury (SCI) usually lead to difficulties in performing locomotor activities, such as walking or climbing stairs. Therefore, an important part of rehabilitation programs is aimed at restoration of gait function. To improve walking ability it seems important to include task-specific repetitive training with focus on higher intensities of walking practice. These concepts have lead to the development of various automated electromechanical gait-training devices, such as the Lokomat, which assist walking practice. Although it is claimed that such devices may be highly beneficial owing to the intense practice possible in non-ambulatory patients, scientific evidence which could justify their relatively high cost is scarce. Recently, within our research institute in collaboration with the Rehabilitation Centre Amsterdam, we have started a randomized controlled clinical trial investigating the effectiveness of Lokomat-training in patients after stroke and SCI on gait performance, quality of life and neuromuscular and cardiovascular properties. This lecture will give an overview on the existing literature concerning the efficacy of electromechanical assisted training for walking and the concepts which would favor the use of these devices will be discussed. In addition, developments and preliminary results from our study will be presented and discussed.