Miracle-dz/UniFAR-FTUs huggingface dataset:
Measuring the Acute Physiological Effects of Leptin in the Carotid Body

Obesity is the healthcare crisis of our generation. Circulating levels of the adipokine leptin are proportional to adiposity and in addition to its role as a satiety factor leptin has been shown to have a host of pleiotropic effects. Among these effects is its role as a respiratory stimulant where it has been shown to have both whole body and central stimulatory effects on breathing. Porzionato et al. (2011) showed that leptin and leptin receptors are selectively expressed in the chemosensing type I cells of the carotid body. Carotid bodies are small chemosensitive organs that act as the primary peripheral oxygen sensors, sitting bilaterally in the bifurcations of the left and right common carotid arteries. In addition to sampling blood gasses on their way to the brain they play a role in setting central sensitivity to CO2 and play a key role in sleep apnea induced hypertension. Whilst leptin receptors in the carotid body have been shown to be functional, the acute physiological effects of leptin on type I cell function has not been assessed. Work presented here shows that acutely administered leptin: (1) increases intracellular Ca2+ that is dependent on extracellular Ca2+ and PI3Kinase in type I cells; (2) increases membrane conductance of type I cells in a BKCa dependent manner, without altering membrane potential – suggesting that BKCa channels are not open at resting membrane potential in CB type I cells; (3) does not increase acid or hypoxia induced membrane depolarization in isolated CB type I cells, but
A study of application of information technology using e-CRM in bank in rural area with special reference to SBI Bank, Sangamner

Technology, people and customer are the three elements on which hinge the success of banking in today’s fast changing economic environment. The ultimate performance of a bank depends upon the satisfaction of its customers. In the emerging competitive and technological driven banking era, banks have to strive hard for retaining and enlarging their customer base. E-CRM, which is the latest buzzword in the corporate sector, is perceived as one of the effective tool in this direction by the banks. Its emphasis is on defining the customers as valuable in the long-term and on viewing customer relationships as learning relationships. The present paper attempts to analyze the concept of e-CRM in State Bank of India in rural area from its various dimensions covering specifically its need, process, present status and future prospects. To justify the purpose research questions have been addressed & on the basis literature review a frame of reference was developed which helped us to answer the research questions & collect data. A qualitative research approach was used for this study. Empirical data was collected through in depth interviews of SBI bank in Sangamner & group of their customers.
Misvaluation: Driver of the Takeover market?

This paper examines the time-variation of the misvaluation hypothesis – that inefficient stock market misvaluation is an important driver of the takeover market in the U.S. takeover market during the years 1978-2017. The main focus is on the financial crisis of 2008, and its effects on the misvaluation hypothesis. Price-to-book value of equity and price-to-residual income model are used as misvaluation proxies. This paper is providing clear evidence that the misvaluation hypothesis is not as strong in the post-2000 period compared to the pre-2000 period. This challenges the misvaluation driven M&A theories (Shleifer and Vishny, 2003; Rhodes-Kropf and Viswanathan, 2004) since during the post-2000 years higher acquirer valuation is associated with cash as a payment method and lower valuation ratios with stock as a payment method. My results are robust for additional tests and controls.
Factors influencing the use of research for policy-making: An umbrella review protocol

Over the last two decades, there has been an emphasis on the concept of evidence-based policy. However, evidence-based policy remains a major challenge and a gap exists in the systematic translation of scientific knowledge into policies. The awareness of this evidence-policy gap has led to a proliferation of research. As the demand for evidence-informed policy-making escalates, so does the need to unveil the mechanisms by which we can influence the process of research uptake. In this paper, we present a protocol for a systematic review. We aim to conduct an umbrella review/overview of reviews about factors affecting the use of research by policy-makers and/or decision-makers in health, education and social services areas. The results of this review could contribute to improving the utilisation of research in the policy-making process, by identifying factors that are most important in influencing the uptake of research by policy-makers.
BETTER ALTERNATIVES FOR STEPWISE DISCRIMINANT ANALYSIS

Discriminant Analysis can best be defined as a technique which allows the classification of an individual into several dictinctive populations on the basis of a set of measurements. Stepwise discriminant analysis ( SDA ) is concerned with selecting the most important variables whilst retaining the highest discrimination power possible. The process of selecting a smaller number of variables is often necessary for a variety number of reasons. In the existing statistical software packages SDA is based on the classic feature selection methods. Many problems with such stepwise procedures have been identified. In this work the new method based on the metaheuristic strategy tabu search will be presented together with the experimental results conducted on the selected benchmark datasets. The results are promising.
EVALUATION OF SEISMIC FAILURE POTENTIAL OF EXISTING RETAINING WALLS USING POTABLE CONE

During the 2004 Niigataken-Chuetsu Earthquake, large number of retaining walls which had supported road embankments in the mountainous area collapsed. This resulted in cutting off road traffic and complete isolation of people in the neighborhood for a long time. The authors studied a number of damaged and undamaged road embankments in the mountainous area where strong ground motions were recorded during the 2004 NiigatakenChuetsu Earthquake. It was revealed that catastrophic failure of embankments constructed on sloping foundation soils were in many cases triggered by damage of retaining walls and most of such damaged retaining walls failed in the mechanism of the bearing capacity failure of the foundation soil. In this study a simple method to examine the seismic stability of existing retaining walls was developed, which evaluates a factor of safety for the bearing capacity failure of foundation on slope under combined loading in conjunction with soil strength parameters obtained by dynamic cone penetration tests using a portable testing device. A good correlation was found between the factor of safety of the surveyed walls derived from the method and the observed deformation of the walls, confirming the effectiveness of the method to identify seismically unstable walls out of existing walls.
Potential problems of stability and convergence in image-based and position-based visual servoing

Visual servoing, using image-based control or position-based control, generally gives satisfactory results. However, in some cases, convergence and stability problems may occur. The aim of this paper is to emphasize these problems by considering an eye-in-hand system and a positioning task with respect to a static target which constrains the six camera degrees of freedom.
Future Concerns Among Families Following Brain Injury in the United States: Views from the Brain Injury Association of America State Affiliates

The objective of this study was to examine brain injury professionals’ perspectives on the future concerns of families of persons with brain injuries in the United States of America. A total of 28 persons in leadership positions with the Brain Injury Association of America (BIAA) participated. Through qualitative data analysis of an open-ended question in an electronic survey containing both qualitative and quantitative questions, participants identified future concerns related to future caregiving responsibilities, financial concerns, living arrangements, recovery, access to professional care, relationships and employment. The findings indicate that many families are unprepared to meet the future care and support needs of their injured family members.
Tail equivalence and its applications

If for two c.d. f. 's F(·) and G(·), 1 – F(x)/1 – G(x) → A, 0 0, bn, n > 1, Fn (anx + bn ) → φ(x), φ(x) non-degenerate, iff Gn (anx + bn )→ φ A−1(x). Conversely, if Fn (anx+bn )→ φ(x), Gn (anx + bn ) → φ'(x), φ(x) and φ'(x) non-degenerate, then there exist constants C >0 and D such that φ'(x) =φ(Cx + D) and limx→∞ 1 — F(x)/1 — G(x) exists and is expressed in terms of C and D, depending on which type of extreme value distribution φ(x) is. These results are used to study domain of attraction questions for products of distribution functions and to reduce the limit law problem for maxima of a sequence of random variables defined on a Markov chain (M.C.) to the independent, identically distributed (i.i.d.) case.
Neighborhood Community Well-being and Social Media

In the following study we adopt a multi-method approach to examine whether the growing use of social media as a channel for hyper-local conversation may provide meaningful insights into the well-being of neighborhood communities. First, through interviews and a questionnaire with 174 residents of 26 neighborhoods we explore what are indicators of neighborhood level well-being, and what are current communication practices around the use of social media to support community well-being. Second, through an analysis of neighborhood-level Twitter messages we examine the extent to which mood and social interactivity in Twitter correspond with our neighborhood well-being indicators. Overall, we found self-reported usage of social media positively correlated with community well-being. However, while smaller neighborhood communities had higher community well-being, they were lower in usage of social media for interacting with neighbors. Only in larger, more urban centers characterized by younger professionals, did Twitter message mood and social interactivity correlate with well-being. Author
PENETAPAN KADAR FLAVONOID TOTAL EKSTRAK DAUN PARE METODE KOMPLEKS KOLORIMETRIDENGAN PENGUKURAN ABSORBANSI SECARA SPEKTROFOTOMETRI

Secara empiris daun pare ( Momordicacharantia ) sangat berpotensi untuk dijadikan sediaan obat tradisional. Untuk itu perlu dikembangkan metode standardisasi sediaan obat tradisional, salah satunya adalah dengan penetapan kadar salah satu kandungan senyawa aktif dalam daun pare. Penelitian sebelumnya menyebutkan bahwa daun pare memiliki kandungan senyawa flavonoid sehingga dapat dilakukan penentuan kadar flavonoid total ekstrak etanol daun pare secara kolorimetri komplementer dengan aluminium klorida untuk menentukan golongan flavon dan flavonol. Dari hasil penelitian diperoleh kandungan flavonoid total dalam daun pare sebesar 8,30% b/b.
Original paper The effect of Ramadan fasting on circadian variation of Turkish patients with acute myocardial infarction

Introduction: The mechanisms of circadian variation in cardiovascular events are not clear. Aim: Evaluation of the effect of Ramadan fasting on circadian variation of acute ST-elevation myocardial infarction (STEMI) in Turkish patients. Material and methods: This comparative cross-sectional study included 151 consecutive patients with acute STEMI. The time of onset of STEMI was determined by the attending physician on the basis of patients’ self-reports. The patients were divided into two group based on the history of fasting. The standard hourly profile of the onset of STEMI was obtained over a 24-h period. Patients were then categorized into four 6-hour increments according to the time that the symptoms began (00:00–05:59; 06:00–11:59; 12:00– 17:59 and 18:00–23:59 h). Results: In all study participants, the highest incidence of STEMI was between 12.00 and 18.00; the odds ratio was 2.77 (95% CI: 2.63–2.92, p < 0.001). In the non-fasting group, the highest incidence of STEMI occurred between 06:00 and 12:00 A.M. The highest incidence of AMI occurred between 12.00 A.M. and 18.00 in patients with fasting; the odds ratio was 2.70 (95% CI: 2.51–2.91, p < 0.001). There were significant differences between fasting and non-fasting groups regarding circadian variation of STEMI (p < 0.001). Conclusions: There are significant changes in the circadian variation of patients with STEMI in relation to Ramadan fasting.
FDA and ISMP Lists of Look-Alike Drug Name Sets With Recommended Tall Man Letters

Since 2008, ISMP has maintained a list of drug name pairs and trios with recommended, bolded tall man (uppercase) letters to help draw attention to the dissimilarities in look-alike drug names. The list includes mostly generic-generic drug name pairs, although a few brand-brand or brand-generic name pairs are included. The US Food and Drug Administration (FDA) list of drug names with recommended tall man letters was initiated in 2001 with the agency’s Name Differentiation Project (www.ismp.org/sc? id=520).
Anaesthetic Effect of Miannaining in Chinese Leopard

Miannaining is a good anaesthetic for animal such as deer,red deer and bear etc.Anaesthetic effect of miannaining on Chinese leopard was observed and evaluated.Result showed that miannaining had good effects of sedation,analgesia and muscle relaxation and its side effect was small.Miannaining is good anaesthetic for Chinese leopard.
Small‐fiber neuropathy

Small‐fiber neuropathy is a common disorder. It is often “idiopathic” and typically presents with painful feet in patients over the age of 60. Autoimmune mechanisms are often suspected, but rarely identified. Known causes of small‐fiber neuropathy include diabetes mellitus, amyloidosis, toxins, and inherited sensory and autonomic neuropathies. Occasionally, small‐fiber neuropathy is diffuse or multifocal. Depending on the type of small‐fiber neuropathy, autonomic dysfunction can be significant or subclinical. Diagnosis is made on the basis of the clinical features, normal nerve conduction studies, and abnormal specialized tests of small‐fiber function. These specialized studies include assessment of epidermal nerve fiber density as well as sudomotor, quantitative sensory, and cardiovagal testing. The sensitivities of these tests range from 59–88%. Each has certain advantages and disadvantages, and the tests may be complementary. Unless an underlying disease is identified, treatment is usually directed toward alleviation of neuropathic pain. © 2002 Wiley Periodicals, Inc. Muscle Nerve 26: 173–188, 2002
Robust Schur Stability of Polynomials with Polynomial

Abstract. The paper considers the robust Schur stability veri cation of polynomials with coe cients depending polynomially on parameters varying in given intervals. A new algorithm is presented which relies on the expansion of a multivariate polynomial into Bernstein polynomials and is based on the decomposition of the family of polynomials into its symmetric and antisymmetric parts. It is shown how the inspection of both polynomial families on the upper half of the unit circle can be reduced to the analysis of two related polynomial families on the real interval [ 1; 1]. Then the Bernstein expansion can be applied in order to check whether both polynomial families have a zero in this interval in common.
Measurement of angular asymmetries in the decays B → K[superscript *]ℓ[superscript +]ℓ[superscript −]

We study the lepton forward-backward asymmetry A FB and the longitudinal K (cid:1) polarization F L , as well as an observable P 2 derived from them, in the rare decays B → K (cid:1) ℓ þ ℓ − , where ℓ þ ℓ − is either e þ e − or μ þ μ − , using the full sample of 471 million B ¯ B events collected at the ϒ ð 4 S Þ resonance with the BABAR , detector at the PEP-II e þ e − collider. We separately fit and report results for the K (cid:1) 0 ð 892 Þ ℓ þ ℓ − and K (cid:1)þ ð 892 Þ ℓ þ ℓ − final states, as well as their combination K (cid:1) ℓ þ ℓ − , in five disjoint dilepton mass-squared bins. An angular analysis of B þ → K (cid:1)þ ℓ þ ℓ − decays is presented here for the first time. DOI: 10.1103/PhysRevD.93. 052015
Managing Human Resources in Public Health Care System in South Asia: Case Study of Pakistan

Health care is considered as one of the fundamental rights of every individual. At the same time, efficient and effective delivery of health care service requires pro-active management of health care professionals. The purpose of this article is to highlight human resource issues and challenges faced by health care professionals in South Asia and identify suitable strategies for better management of health care professionals. By using data from a pilot study in Pakistan’s public health sector in the province of Punjab, the article explores ways of implementing productive reforms to upgrade human resource management system in the public health care sector in South Asian countries.
HUMAN-BODY MODELING AND POSITION SPECIFICATION FOR FORENSIC AUTOPSY DATA VISUALIZATION

This paper proposes the methods for creating a humanbody model that reflects individual victim characteristics and obtaining position information on the human-body model for the purpose of forensic autopsy data visualization. Although modern imaging technologies, such as CT and MRI, make it possible to obtain fine volumetric human-body model, these technologies are still not widely used in the real forensic autopsy sites due to the cost. To enable a forensic specialist to easily create 3D models of victims, we propose a new method which uses an affordable depth-sensing camera and requires few user interactions. To visualize the autopsy data directly on a 3D model, we also propose a method for specifying a position on the 3D model without impeding the progress of the autopsy procedure.
University of Groningen Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation Wiersma,

Atrial fibrillation (AF), the most common progressive tachyarrhythmia, results in structural remodeling which impairs electrical activation of the atria, rendering them increasingly permissive to the arrhythmia. Previously, we reported on endoplasmic reticulum stress and NAD+ depletion in AF, suggesting a role for mitochondrial dysfunction in AF progression. Here, we examined mitochondrial function in experimental model systems for AF (tachypaced HL-1 atrial cardiomyocytes and Drosophila melanogaster) and validated findings in clinical AF. Tachypacing of HL-1 cardiomyocytes progressively induces mitochondrial dysfunction, evidenced by impairment of mitochondrial Ca2+-handling, upregulation of mitochondrial stress chaperones and a decrease in the mitochondrial membrane potential, respiration and ATP production. Atrial biopsies from AF patients display mitochondrial dysfunction, evidenced by aberrant ATP levels, upregulation of a mitochondrial stress chaperone and fragmentation of the mitochondrial network. The pathophysiological role of mitochondrial dysfunction is substantiated by the attenuation of AF remodeling by preventing an increased mitochondrial Ca2+-influx through partial blocking or downregulation of the mitochondrial calcium uniporter, and by SS31, a compound that improves bioenergetics in mitochondria. Together, these results show that conservation of the mitochondrial function protects against tachypacing-induced cardiomyocyte remodeling and identify this organelle as a potential novel therapeutic target.
Combining social marketing and intervention mapping

Purpose – This paper aims to present a description of the development and implementation of a combined schooland community-based intervention for the prevention of overweight among children, using the combined methods of social marketing (SMk) and intervention mapping (IM). Design/methodology/approach – The SMk total process planning (TPP) framework was used, a simple but robust framework that consists of five stages: scoping, development, implementation, © Lyne M.G. Blanchette. Published by Emerald Group Publishing Limited. This article is published under the Creative Commons Attribution (CC BY 3.0) licence. Anyone may reproduce, distribute, translate and create derivative works of this article (for both commercial & non-commercial purposes), subject to full attribution to the original publication and authors. The full terms of this licence may be seen at http://creativecommons.org/licences/by/3.0/legalcode. The publication of this study was supported by a grant of The Netherlands Organization for Scientific Research. The authors are grateful to the parents, children and staff at the schools who took part in this intervention, to the local stakeholders for collaborating with them and to Evelyne Meynen and her “Schuttelaar and partners” colleagues for their contribution to the qualitative research and their marketing expertise. The authors are especially grateful to Cornelis Krul for his leadership and commitment in the SMk approach. Authors’ contributions: Lyne M.G. Blanchette and Vivian M. Van de Gaar contributed equally to this article. LB was responsible for the design and development of the intervention, conceptualised and wrote the manuscript. VvdG contributed considerably in all phases to drafting the manuscript. HR helped together with WJ with the conceptualization of this manuscript and critically revised the manuscript. JF critically revised the manuscript on important content with regard to SMk. WJ helped, together with HR with the conceptualization of this manuscript and was involved in all stages of drafting the manuscript. All authors read, critically reviewed the manuscript and approved the final manuscript. The current issue and full text archive of this journal is available on Emerald Insight at: www.emeraldinsight. com/2042-6763.htm
Title : Parenting and adolescent health : Observed parenting behavior is associated with inflammation two and half years later in a community sample

a. Department of Psychology, University of Oregon, Eugene, OR, USA b. Melbourne School of Psychological Sciences, The University of Melbourne, Victoria, Australia c. Melbourne Dental School, Oral Health CRC, 720 Swanston Street, Carlton, The University of Melbourne, Victoria, Australia d. Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria, Australia e. Oregon Research Institute, Eugene, OR, USA f. Orygen Research Centre, Centre for Youth Mental Health, University of Melbourne, Victoria, Australia