Miracle-dz/UniFAR-FTUs huggingface dataset:
How Does Labor Market Size Affect Firm Capital Structure? Evidence from Large Plant Openings

I examine how the labor market in which firms operate affects their capital structure decisions. Using the US Census Bureau data, I exploit a large plant opening as an abrupt increase in the size of a local labor market. I find that a new plant opening leads to a 2.6% to 3.9% increase in the debt-to-capital ratio of existing firms in the “winner” county relative to the “runner-up” choice. This result is consistent with larger labor markets making a job loss less costly, which in turn reduces indirect costs of financial distress. Moreover, this spillover effect is larger for firms 1) that have a larger fraction of employees in the affected county, 2) that employ the same type of workers as the new plant, and 3) that have larger unexploited benefits of debt.
A Simply Equipped Fourier Ptychography Platform Based on an Industrial Camera and Telecentric Objective

Fourier ptychography microscopy (FPM) is a recently emerged computational imaging method, which combines the advantages of synthetic aperture and phase retrieval to achieve super-resolution microscopic imaging. FPM can bypass the diffraction limit of the numerical aperture (NA) system and achieve complex images with wide field of view and high resolution (HR) on the basis of the existing microscopic platform, which has low resolution and wide field of view. Conventional FPM platforms are constructed based on basic microscopic platform and a scientific complementary metal–oxide–semiconductor (sCMOS) camera, which has ultrahigh dynamic range. However, sCMOS, or even the microscopic platform, is too expensive to afford for some researchers. Furthermore, the fixed microscopic platform limits the space for function expansion and system modification. In this work, we present a simply equipped FPM platform based on an industrial camera and telecentric objective, which is much cheaper than sCMOS camera and microscopic platform and has accurate optical calibration. A corresponding algorithm was embedded into a conventional FP framework to overcome the low dynamic range of industrial cameras. Simulation and experimental results showed the feasibility and good performance of the designed FPM platform and algorithms.
Proton Irradiation Effects on the Time-Dependent Dielectric Breakdown Characteristics of Normally-Off AlGaN/GaN Gate-Recessed Metal-Insulator-Semiconductor Heterostructure Field Effect Transistors

In this work, we investigated the time-dependent dielectric breakdown (TDDB) characteristics of normally-off AlGaN/GaN gate-recessed metal–insulator–semiconductor (MIS) heterostructure field effect transistors (HFETs) submitted to proton irradiation. TDDB characteristics of normally-off AlGaN/GaN gate-recessed MISHFETs exhibited a gate voltage (VGS) dependence as expected and showed negligible degradation even after proton irradiation. However, a capture emission time (CET) map and cathodoluminescence (CL) measurements revealed that the MIS structure was degraded with increasing trap states. A technology computer aided design (TCAD) simulation indicated the decrease of the vertical field beneath the gate due to the increase of the trap concentration. Negligible degradation of TDDB can be attributed to this mitigation of the vertical field by proton irradiation.
‘A Healthy CIT’: An Investigation into Student Health Metrics, Lifestyle Behaviours and the Predictors of Positive Mental Health in an Irish Higher Education Setting

Higher Education Institutions (HEIs) are potent health promotion settings, uniquely positioned to aid societal efforts to combat non-communicable diseases (NCDs). International evidence suggests that health metrics and lifestyle behaviours of higher education students are sub-optimal, yet a dearth of contemporary Irish data exists. This study aimed to examine sex differences in student lifestyle behaviours and identify significant predictors of positive mental health in an Irish HEI setting. An online questionnaire instrument distributed to all registered students (n = 11,261) gathered data regarding a multitude of health and lifestyle domains. Many items were adapted from previous Irish research. Further validated scales included the Alcohol Use Disorders Identification Test (AUDIT), Mental-Health Index 5 (MHI-5) and the Energy and Vitality Index (EVI). Self-reported height/body mass were also recorded. In total, 2267 responses were analysed (51.7% female, 48.3% male). Both sexes demonstrated poor sleeping patterns, hazardous drinking and sub-optimal fruit and vegetable intake. The calculated prevalence of overweight/obesity was 38.2%. Both sexes underestimated obesity. Males underestimated and females overestimated overweight. Males displayed riskier behavioural patterns with regard to illicit substances, drinking, and sexual partners. Females reported greater psychological distress. Multivariate linear regression identified 8 variables as predictors of positive mental health, accounting for 37% of the variance in EVI scores. In conclusion, HEI students would benefit from sex-specific multi-level health promotion initiatives to remove macro-level barriers to healthier lifestyles.
In-situ aircraft observations of ice concentrations within clouds over the Antarctic Peninsula and Larsen Ice Shelf

Abstract. In-situ aircraft observations of ice crystal concentrations in Antarctic clouds are presented for the first time. Orographic, layer and wave clouds around the Antarctic Peninsula and Larsen Ice shelf regions were penetrated by the British Antarctic Survey's Twin Otter aircraft, which was equipped with modern cloud physics probes. The clouds studied were mostly in the free troposphere and hence ice crystals blown from the surface are unlikely to have been a major source for the ice phase. The temperature range covered by the experiments was 0 to −21 °C. The clouds were found to contain supercooled liquid water in most regions and at heterogeneous ice formation temperatures ice crystal concentrations (60 s averages) were often less than 0.07 l −1 , although values up to 0.22 l −1 were observed. Estimates of observed aerosol concentrations were used as input into the DeMott et al. (2010) ice nuclei (IN) parameterisation. The observed ice crystal number concentrations were generally in broad agreement with the IN predictions, although on the whole the predicted values were higher. Possible reasons for this are discussed and include the lack of IN observations in this region with which to characterise the parameterisation, and/or problems in relating ice concentration measurements to IN concentrations. Other IN parameterisations significantly overestimated the number of ice particles. Generally ice particle concentrations were much lower than found in clouds in middle latitudes for a given temperature. Higher ice crystal concentrations were sometimes observed at temperatures warmer than −9 °C, with values of several per litre reached. These were attributable to secondary ice particle production by the Hallett Mossop process. Even in this temperature range it was observed that there were regions with little or no ice that were dominated by supercooled liquid water. It is likely that in some cases this was due to a lack of seeding ice crystals to act as rimers to initiate secondary ice particle production. This highlights the chaotic and spatially inhomogeneous nature of this process and indicates that the accurate representation of it in global models is likely to represent a challenge. However, the contrast between Hallett Mossop zone ice concentrations and the fairly low concentrations of heterogeneously nucleated ice suggests that the Hallet Mossop process has the potential to be very important in remote, pristine regions such as around the Antarctic coast.
A Nonlinear Goal Programming Model for University Admission Capacity Planning with Modified Differential Evolution Algorithm

This paper proposes a nonlinear Goal Programming Model (GPM) for solving the problem of admission capacity planning in academic universities. Many factors of university admission capacity planning have been taken into consideration among which are number of admitted students in the past years, total population in the country, number of graduates from secondary schools, desired ratios of specific specialties, faculty-to-students ratio, and the past number of graduates. The proposed model is general and has been tested at King Abdulaziz University (KAU) in the Kingdom of Saudi Arabia, where the work aims to achieve the key objectives of a five-year development plan in addition to a 25-year future plan (AAFAQ) for universities education in the Kingdom. Based on the results of this test, the proposed GPM with a modified differential evolution algorithm has approved an ability to solve general admission capacity planning problem in terms of high quality, rapid convergence speed, efficiency, and robustness.
The papillomavirus E5 gene does not affect EGFR transcription and overall survival in cervical cancer

The human papillomavirus (HPV) E5 gene encodes a small and highly hydrophobic oncoprotein that affects immune evasion, cell proliferation, loss of apoptotic capacity and angiogenesis in tumors. E5 shows an affinity for biological membranes and was associated with an increase of epidermal growth factor/epidermal growth factor receptor (EGF/EGFR) signaling through the accumulation of EGFR in cellular membranes. Due to the frequent integration of the HPV genome into the host cell genome, E5 is frequently not transcribed in cervical tumors.
Kinetic Parameter Estimation and Mathematical Modelling of Lipase Catalysed Biodiesel Synthesis in a Microreactor

Development of green, clean, and sustainable processes presents new challenges in today’s science. Production of fuel is no exception. Considering the utilisation of various renewable sources, the synthesis of biodiesel, characterised as more environmentally-friendly then fossil fuel, has drawn significant attention. Even though the process based on chemical transesterification in a batch reactor still presents the most used method for its production, enzyme catalysed synthesis of biodiesel in a microreactor could be a new approach for going green. In this research, edible sunflower oil and methanol were used as substrates and lipase from Thermomyces lanuginosus (Lipolase L100) was used as catalyst for biodiesel synthesis. Experiments were performed in a polytetrafluoroethylene (PTFE) microreactor with three inlets and in glass microreactors with two and three inlets. For a residence time of 32 min, the fatty acids methyl esters (FAME) yield was 30% higher than the yield obtained for the glass microreactor with three inlets. In comparison, when the reaction was performed in a batch reactor (V = 500 mL), the same FAME yield was achieved after 1.5 h. In order to enhance the productivity of the process, we used proposed reaction kinetics, estimated kinetic parameters, and a mathematical model we developed. After validation using independent experimental data, a proposed model was used for process optimization in order to obtain the highest FAME yield for the shortest residence time.
Aptamer-Based Fluorescent Biosensing of Adenosine Triphosphate and Cytochrome c via Aggregation-Induced Emission Enhancement on Novel Label Free DNA-Capped Silver Nanoclusters/Graphene Oxide Nanohybrids.

Four fluorescent DNA-AgNCs were designed and synthesized with differences in lengths of cytosine-rich DNA strand (as stabilizing agent) and target specific strand DNA aptamers for adenosine triphosphate (ATP) and cytochrome c (Cyt c). After their nanohybrid formation with graphene oxide (GO), it was unexpectedly found that, depend on the composition of the base and length of strand DNA aptamer, the fluorescence intensity of three of the nanohybrids significantly enhanced. Our experimental observations and quantum mechanical (QM) calculations provided an insight into the mechanisms underlying the behavior of DNA-AgNCs/GO nanohybrids. The enhanced fluorescence found to be attributed to the aggregation-induced emission enhancement (AIE) characteristic of the DNA-AgNCs adsorbed on the GO surface, as confirmed evidently by both fluorescence and transmission electron microscopy. The AIE is a result of hardness and oxidizing property of GO, which lead to enhanced argenophilic interaction and thus to increased Ag(I)-DNA complex shell aggregation. Consequently, two of the DNA-AgNCs/GO nanohybrids were successfully extended to construct highly selective, sensitive, label free, and simple aptasensors for biosensing of ATP (LOD=0.42 nM) and Cyt c (LOD=0.42 nM) in lysed Escherichia coli DH5 α cells and mouse embryonic stem cells, respectively. These fundamental findings are expected to significantly influence the designing and engineering of new AgNCs/GO-based AIE biosensors.
Does Board Independence Affect Audit Fees? Evidence from Recent Regulatory Reforms

Abstract To enhance board oversight, since 2002, US legislation has required listed companies to have a majority independent board. This paper uses this legislative change to examine the relation between board independence and audit fees. To provide a clean estimate of this relation, we adopt a difference-in-difference approach using a sample matched on client firm characteristics. We find that greater board independence is insignificantly associated with a change in audit fees when client firms operate in a weak information environment. When the information environment is strong, greater board independence is associated with an increase in audit fees. Our results are consistent with the nascent theory emphasizing information asymmetry and provide insight into the effectiveness of the mandated board independence in relation to audit quality.
Meander-Line Slot-Loaded High-Sensitivity Microstrip Patch Sensor Antenna for Relative Permittivity Measurement

A high-sensitivity microstrip patch sensor antenna (MPSA) loaded with a meander-line slot (MLS) is proposed for the measurement of relative permittivity. The proposed MPSA was designed by etching the MLS along the radiating edge of the patch antenna, and it enhanced the relative permittivity sensitivity with an additional effect of miniaturization in the patch size by increasing the slot length. The sensitivity of the proposed MPSA was compared with that of a conventional rectangular patch antenna and a rectangular slit (RS)-loaded MPSA, by measuring the shift in the resonant frequency of the input reflection coefficient. Three MPSAs were designed and fabricated on a 0.76 mm-thick RF-35 substrate to resonate at 2.5 GHz under unloaded conditions. Sensitivity comparison was performed by using five different standard dielectric samples with dielectric constants ranging from 2.17 to 10.2. The experiment results showed that the sensitivity of the proposed MPSA is 6.84 times higher for a low relative permittivity of 2.17, and 4.57 times higher for a high relative permittivity of 10.2, when compared with the conventional MPSA. In addition, the extracted relative permittivity values of the five materials under tests showed good agreement with the reference data.
Current evidence on thyroid related adverse events in patients treated with protein tyrosine kinase inhibitors

Abstract Tyrosine kinase inhibitors (TKI) are gaining more ground in oncology, they are widely used in the treatment of multiple types of cancers; still important side effects limit their efficacy. The aim of this study is to evaluate the existing medical literature on TKI induced thyroid dysfunction, to assess the adverse effects of targeted therapy on thyroid function in oncological patients and to evaluate the effects of thyroid dysfunction on disease prognosis. We included in this review 22 original studies published between 2010 and 2019. We used the PubMed database to search for articles upon the development of hypothyroidism and hyperthyroidism in TKI treated patients. After a careful review of the existing literature, we selected the relevant studies and cross-referenced the bibliography of each paper. A number of 1641 patients were included in our review. We found that thyroid dysfunction is not a rare side effect of TKI treatment, approximately 33% of the total number of patients presented clinical hypothyroidism. We also studied the necessity of thyroid hormone substitution treatment, a quarter of evaluated patients needed substitution therapy. Multiple studies showed that there is a link between a patient developing hypothyroidism and progression free survival. Hypothyroidism is a frequent side effect of TKI treatment, which affects the quality of life, sometimes even determines physicians to stop TKI treatment altogether. Our study underlines the necessity of TSH baseline testing and monitoring in patients treated with TKI agents.
Pricing 2-colour rainbows : nonparametric methods using copulae

This paper investigates the use of copulae for non parametric pricing of multivariate contingent claims. Price estimates and no-arbitrage bounds for various types of two-colour rainbow options on the South African equity and bond markets were calculated. Implied marginal risk-neutral distributions were derived nonparametrically from each assets option price spread. This wa. '3 achieved in a very simple manner by assuming that, for each of the underlying assets in question, a continuum of option prices exist. Cubic splines were used to fit this continuum to the implied volatilities of the actual options available. Two nonparametric copulae were considered: an empirical copula based directly upon the data and a kernel copula derived from a smooth two-dimensional kernel approximation of the historic density function. In addition, various parametric copulae were considered for comparison purposes. The differences between each of these approaches was found to vary from one type of rainbow to another. vii Un ive rsi ty of Ca pe To wn Chapter
A Novel Niosome-Encapsulated Essential Oil Formulation to Prevent Aspergillus flavus Growth and Aflatoxin Contamination of Maize Grains During Storage

Aflatoxin (AF) contamination of maize is a major concern for food safety. The use of chemical fungicides is controversial, and it is necessary to develop new effective methods to control Aspergillus flavus growth and, therefore, to avoid the presence of AFs in grains. In this work, we tested in vitro the effect of six essential oils (EOs) extracted from aromatic plants. We selected those from Satureja montana and Origanum virens because they show high levels of antifungal and antitoxigenic activity at low concentrations against A. flavus. EOs are highly volatile compounds and we have developed a new niosome-based encapsulation method to extend their shelf life and activity. These new formulations have been successfully applied to reduce fungal growth and AF accumulation in maize grains in a small-scale test, as well as placing the maize into polypropylene woven bags to simulate common storage conditions. In this latter case, the antifungal properties lasted up to 75 days after the first application.
Pharmacokinetic Alteration of Paclitaxel by Ferulic Acid Derivative

P-glycoprotein (P-gp) is known to be involved in multidrug resistance (MDR) and modulation of pharmacokinetic (PK) profiles of substrate drugs. Here, we studied the effects of synthesized ferulic acid (FA) derivatives on P-gp function in vitro and examined PK alteration of paclitaxel (PTX), a well-known P-gp substrate drug by the derivative. Compound 5c, the FA derivative chosen as a significant P-gp inhibitor among eight FA candidates by in vitro results, increased PTX AUCinf as much as twofold versus the control by reducing PTX elimination in rats. These results suggest that FA derivative can increase PTX bioavailability by inhibiting P-gp existing in eliminating organs.
Temporal Coding of Single Auditory Nerve Fibers Is Not Degraded in Aging Gerbils

People suffering from age-related hearing loss typically present with deficits in temporal processing tasks. Temporal processing deficits have also been shown in single-unit studies at the level of the auditory brainstem, midbrain, and cortex of aged animals. In this study, we explored whether temporal coding is already affected at the level of the input to the central auditory system. Single-unit auditory nerve fiber recordings were obtained from 41 Mongolian gerbils of either sex, divided between young, middle-aged, and old gerbils. Temporal coding quality was evaluated as vector strength in response to tones at best frequency, and by constructing shuffled and cross-stimulus autocorrelograms, and reverse correlations, from responses to 1 s noise bursts at 10–30 dB sensation level (dB above threshold). At comparable sensation levels, all measures showed that temporal coding was not altered in auditory nerve fibers of aging gerbils. Furthermore, both temporal fine structure and envelope coding remained unaffected. However, spontaneous rates were decreased in aging gerbils. Importantly, despite elevated pure tone thresholds, the frequency tuning of auditory nerve fibers was not affected. These results suggest that age-related temporal coding deficits arise more centrally, possibly due to a loss of auditory nerve fibers (or their peripheral synapses) but not due to qualitative changes in the responses of remaining auditory nerve fibers. The reduced spontaneous rate and elevated thresholds, but normal frequency tuning, of aged auditory nerve fibers can be explained by the well known reduction of endocochlear potential due to strial dysfunction in aged gerbils. SIGNIFICANCE STATEMENT As our society ages, age-related hearing deficits become ever more prevalent. Apart from decreased hearing sensitivity, elderly people often suffer from a reduced ability to communicate in daily settings, which is thought to be caused by known age-related deficits in auditory temporal processing. The current study demonstrated, using several different stimuli and analysis techniques, that these putative temporal processing deficits are not apparent in responses of single-unit auditory nerve fibers of quiet-aged gerbils. This suggests that age-related temporal processing deficits may develop more central to the auditory nerve, possibly due to a reduced population of active auditory nerve fibers, which will be of importance for the development of treatments for age-related hearing disorders.
A Perspective on the Future Role of Aptamers in Analytical Chemistry.

It has been almost 30 years since the invention of SELEX (Systematic Evolution of Ligands by Exponential Enrichment) methodology and the description of the first aptamers. In retrospect over the past 30 years, advances in aptamer development and application have demonstrated that aptamers are potentially useful reagents that can be employed in diverse areas within analytical chemistry, biotechnology, biomedicine, and molecular biology. While often touted as artificial antibodies with an ability to be selected for any target, aptamer development, unfortunately, lags behind development of analytical methodologies that employ aptamers, hindering deeper integration into the application of analytical tool development. This perspective covers recent advances in SELEX methodology coupled with post-selection procedures all aimed at enhancing affinity and specificity of the selected aptamers - what we view as a critical barrier in the future role of aptamers in analytical chemistry. We discuss post-selection modifications that can be used for enhancing performance of the selected aptamers in analytical device by including understanding intermolecular interaction forces in the binding domain. While highlighting promising properties of aptamers that enable several analytical advances, we provide discussion on the challenges of penetration of aptamers in the analytical field.