Miracle-dz/UniFAR-FTUs huggingface dataset:
MiR-1423 p is a tumor promoter by directly targeting FOXO 4 to promote gastric cancer cell growth and suppress cell apoptosis in gastric cancer

Background: miRNAs play an important role in cancer progression. Aberrant expression of miR-142-3p is related with various cancers. However, the function of miR-142-3p in gastric cancer (GC) remains poorly studied. We aim to investigate the biological roles and mechanisms of miR-142-3p in GC. Methods: miRNA-142-3p expression level in GC tissues and cell lines was determined using Real-Time PCR. Cell proliferation was analyzed by MTT. Cell apoptosis was analyzed by TUNEL assay. The target gene FOXO4 of miR-142-3p was predicted upon bioinformatics tool and verified by dual-luciferase reporter assay, Real-Time PCR, and Western Blot. The molecular mechanismassociated genes were measured using Real-Time PCR and Western Blot. Results: miR-142-3p is up-regulated in gastric cancer tissues and cell lines. MiR-142-3p promotes gastric cancer cell growth and suppresses cell apoptosis by binding to 3’UTR of FOXO4 and degrading the level of FOXO4 to decrease the expression of p21, p27, Bim, and FASL. Moreover, a significant negative correlation between miR-142-3p and FOXO4 was found in seven patients with gastric cancer. Conclusion: miR-142-3p acts as a tumor promoter by targeting FOXO4 to decrease the expression of p21, p27, Bim, and FASL in the progression of GC. miR-142-3p and FOXO4 may be potential therapeutic targets for gastric carcinoma patients.
Doctors as targets of unwanted sexual attention

E-mail: karin.ro@legeforeningen.no Institute for Studies of the Medical Profession – LEFO She has contributed to the idea, design, collection and interpretation of the data and preparation/revision of the manuscript, and has approved the submitted manuscript version. Karin Isaksson Rø, PhD, MHA, specialist in occupational medicine and Director of the Institute. She has experience in counselling and courses for doctors, as well as in research on the working conditions of doctors. The author has completed the ICMJE form and declares no conflicts of interest.
A Mediational Model of the Creative Process

PAGE Unconscious thought has long been theorized to play an important role in the creative process. Although this relationship has been extensively researched, the specific pathways leading from unconscious cognitive processes to useful creative output are still poorly understood. Thrash and Elliot (2003) have elaborated on inspiration as a psychological construct. The current study tests a mediational model in which inspiration mediates the relationship between unconscious thought and creative output using four conditions (control, conscious thought, 1-back, and 2-back). Preliminary analyses indicated a failure of the manipulation to influence unconscious thought, inspiration, or creativity. Further analyses supported the pattern of results predicted by the mediational model, such that attributions of an idea to unconscious thought predicted inspiration at the moment of getting an idea, which in turn predicted self-ratings of creativity of the completed story.
The Data Protection, Privacy and Electronic Communications (Amendments etc) (EU Exit) Regulations 2019

The Secretary of State makes these Regulations in exercise of the powers conferred by sections 8(1) and 23(1) of, paragraph 1(1) of Schedule 4 to and paragraph 21 of Schedule 7 to the European Union (Withdrawal) Act 2018(1), section 211(2) of the Data Protection Act 2018(2) and section 2(2) of the European Communities Act 1972(3). In accordance with paragraph 3(1) of Schedule 4 to the European Union (Withdrawal) Act 2018, these Regulations are made with the consent of the Treasury. The Secretary of State is a Minister designated for purposes of section 2(2) of the European Communities Act 1972 in respect of matters relating to electronic communications. In accordance with paragraphs 1(1) and 12(1) of Schedule 7 to the European Union (Withdrawal) Act 2018, section 211(5) of the Data Protection Act 2018 and paragraph 2(2) of Schedule 2 to the European Communities Act 1972 a draft of this instrument has been laid before, and approved by a resolution of, each House of Parliament.
The Conceptual Model of Religious-based Entrepreneurship in Malaysia : A Value-chain Approach

Technology offers new resources that impact religious activities as in worships and religious outreach. For instance, in activities related to worship the new technology gave Muslims the easy access to the digital call to prayer, by downloading prayer schedules. Technology also gave Hindus, Christians, Muslims and Buddhists online search capabilities to look up for scriptures and verses of their holy book and thus enabling them the means to enrich their religious knowledge. Religious groups also gain the opportunity to communicate online through technology advancement and the new media. The new communication technologies have altered the boundaries of local and remote participation in religious outreach such as Abstract
Acoustic Staggered Grid Modeling in IWAVE

IWAVE is a framework for time-domain regular grid finite difference and finite element methods. The IWAVE package includes source code for infrastructure component, and implementations of several wave physics modeling categories. This paper presents two sets of examples using IWAVE acoustic staggered grid modeling. The first set illustrates the effectiveness of a simple version of Perfectly Matched Layer absorbing boundary conditions. The second set reproduce illustrations from a recent paper on error propagation for heterogeneous medium simulation using finite differences, and demostrate the interface error effect which renders all FD methods effectively first-order accurate. The source code for these examples is packaged with the paper source, and supports the user in duplicating the results presented here and using IWAVE in other settings.
C 047 , Page 1 GEOMETRICAL OPTIMISATION OF THE REVOLVING VANE COMPRESSOR

The newly designed compressor, namely Revolving Vane Compressor has been introduced [1]. As compared with conventional rolling and sliding vane compressors, such a design exhibits significant mechanical benefits. This paper shows how the geometry of this compressor can be further optimized to enhance its mechanical performance. A constrained multivariable direct search optimization technique has been linked with the mathematical model to search for a set of combination of design dimensions that produces the highest coefficient of performance (COP), under preset design constraints and operational conditions. Theoretical results suggested that an increase of 4 % in COP is possible. This is achieved mainly by having a thinner and longer compressor as opposed to a shorter and fatter design.
Multi-Gap Superconductivity on MgB 2 Chapter in Physics of Particles and Nuclei · January 2006

We using our two-band model for the explanation of two coupled superconductivity gaps for MgB2.To study the effect of the increasing of Tc in MgB2 due to the enhanced interband pairing scattering. We have proposed two channel scenario of superconductivity: the conventional channel which is connected with BCS mechanism in different zone and the unconventional channel which describes the transfer or tunneling of Cooper pair between two bands.
CFD Modelling of Multiple Layer Anti Abrasion Beam Implementation at 100 MW Tarahan CFB Boiler

Since commissioning, 100 MW Coal fired Tarahan Power Plant which uses Circulating Fluidized Bed (CFB) Boiler suffered many problems, especially on water wall tubes abrasion. This condition is merely due to higher wearing rate of bed particles to the wall tubes than that of expecting design. In order to reduce wall tube wearing rate, seven layers anti abrasion refractory beam will be installed at the elevation of 16 up to 40 m around the wall tubes. Before implementation computational fluid dynamics (CFD) modeling was conducted to show the flow of the bed materials through the water wall tubes and the influence of refractory beam on heat transfer reduction was also studied. The results show that the flow of the bed material changes and tends to reduce their friction on the wall tubes without reduces heat transfer rate significantly. Since more than six months of the anti abrasion beam implementation, boiler shutdown due to wall tube abrasion was not observed yet. It means that abrasion beam installation could at least reduce significantly wearing rate.
Stage II colon cancer patients with no more than 6 lymph nodes harvested may be understaged and should be considered for adjuvant chemotherapy : a retrospective analysis of 87 , 090 patients in the SEER database

Background: We suspect that patients with stage II colon cancer with only a few lymph nodes harvested (LNH) may be understaged. Therefore, we hypothesize that stage II patients with a few LNH have a poorer cancer specific-survival (CSS) compared with N1a (stage III) patients with adequate LNH. Methods: We analyzed patients with stage II or N1a (stage III) colon cancer based on data from the US Surveillance, Epidemiology, and End Results (SEER) database. Survival was analyzed using the Kaplan-Meier method, and the log-rank test was performed to identify differences. A multivariate Cox proportional hazards model was used to analyze the risk factors. Results: In all, 87,090 patients (66,820 stage II patients and 20,270 N1a patients) from the SEER database were included in the analysis. We selected no more than 6 LNH to be “a few” LNH in stage II patients and at least 12 LNH as adequate LNH in N1a (stage III) patients. A Kaplan-Meier analysis suggested that stage II patients with ≤6 LNH had a poorer CSS than the N1a (stage III) patients with ≥12 LNH (P<0.001). A multivariate analysis showed that compared with stage II patients with ≤6 LNH, N1a (stage III) patients with ≥12 LNH were more likely to exhibit a better CSS (HR 0.839, 95% CI 0.793-0.887, P<0.001). Conclusions: Stage II colon cancer patients with no more than 6 lymph nodes harvested may be understaged and should be considered for adjuvant chemotherapy.
AMS : An Adaptive Multimedia Server Architecture

In most existing distributed multimedia architectures the term adaptivity covers techniques for increasing or (more often) reducing the quality of transmitted or presented media streams, in order to cope with different network and client capabilities. This kind of defensive adaptivity, also called stream-level adaptivity, is typically achieved by varying the streams’ spatial and/or temporal resolution. However, for multimedia servers stream level adaptivity might not be sufficient in cases where computational resources become bottlenecks or latency times to the requesting clients become critical. In order to avoid increasing numbers of admission rejections or client reneging, the server should apply an offensive adaptation strategy. This paper presents a distributed multimedia streaming server architecture that builds upon the idea of server-level adaptivity, where new computational resources are acquired on demand and certain server applications are migrated or replicated to recommended locations. The goal is to maximize the number of admittable client requests by reducing network traffic, startup latencies and/or keeping subsets of server nodes load-balanced. The architecture consists of three distinguished interacting applications that can be migrated or replicated on demand, resulting in a virtual server spawning a dynamic number of server nodes over time. As an infrastructure for application migration and replication, a CORBA-based mobile agent system (Vagabond2 ) is used. This infrastructure also manages the set of nodes belonging to the media server cluster and provides recommendations for a proper placement of multimedia server applications. For adaptational issues the server architecture provides information on currently admitted client requests, and future (not yet admitted) requests.
The design and aesthetics of wearable activity trackers

Aesthetics in the context of human-computer interaction has been an area of much research. However this research has focused primarily on usability. In recent years wearable products have seen an increase in user adoption. Currently the form factors of fitness trackers on the market are limited and have distinct aesthetics and physical forms. This research investigates the relationship between activity tracker and wearer, and the resulting aesthetic experience. The author applies novel approaches as methods of research: (1) an investigatory diary study followed by a participatory design workshop which aims to understand the user’s challenges with current devices; (2) designing and prototyping, through which the participants’ ideas are evaluated and their designs subsequently realised as non-functional low-fidelity prototypes; and (3) in-situ evaluation of prototypes during which the prototypes are given to participants to use within their normal routine. During this final stage they are asked to document their reflections in form of an evaluatory diary. The study concludes with closing interviews. The author presents themes which designers of future wearable products should be conscious of during the design process: ​sensory qualities of the device​, ​perceived properties of the device,​ ​the context of use​, and ​other influencing factors.
Regional Development of Residential and Commercial Real Estate in Poland and the Risk of Real Estate Cycles

The property market is local and thus regional factors have a very important impact on its evolution. However, global factors also have an impact. This paper explains that fast economic growth can lead to strong cycles in the market and also cause problems for the stability of the economy. With a case study of the housing market in Warsaw we show that very different economic and regulatory factors can create cycles which look quite similar at first sight. We conclude that one needs to understand the fundamentals of a given cycle to be able to smooth it. The main driver of the cycle in Poland is the significant shortage of housing units, and thus people react very strong to any possibility of improving their living conditions. Rises in income or declines of mortgage costs trigger a demand boom, while the supply side is constrained by regulations and increasing construction costs. The excessive demand leads to quite strong cycles which could be smoothed with a large amount of rental housing.
Hidden Markov Models for disease progression Hidden Markov Models per la progressione di patologia

Disease progression models are a powerful tool for understanding and predicting the development of a disease, given some longitudinal measurements obtained from a sample of patients. These models are able to give some insights about the disease progression through the analysis of patients histories and could be also used to predict the future course of the disease in an individual. In particular, Hidden Markov Models (HMMs) are a useful tool for disease modeling since they allow to model situations where the state of the disease is not observable, by giving the possibility to incorporate some priors and constraints. We applied our models to a simulated dataset by considering a generalization of HMMs with continuous time and multivariate outcome. Abstract I modelli di progressione di patologia sono un potente strumento per comprendere e prevedere lo sviluppo di una patologia, date delle misurazioni longitudinali ottenute da un campione di pazienti. Questi modelli sono in grado di arricchire la conoscenza sulla progressione della patologia attraverso l’analisi della storia dei pazienti e possono anche essere usati per predire il corso futuro della patologia di un individuo. In particolare, gli Hidden Markov Models (HMMs) sono un utile strumento per la modellazione di patologia in quanto permettono di costruire un modello in situazioni in cui lo stato della patologia non è osservabile, dando la possibilità di incorporare delle prior e dei vincoli. Abbiamo applicato i nostri modelli a un dataset simulato considerando una generalizzazione degli HMM a tempo continuo e risposta multivariata. Andrea Martino, Giuseppina Guatteri, Anna Maria Paganoni Department of Mathematics, Politecnico di Milano, via Bonardi 9, 20133, Milan, Italy e-mail: andrea.martino@polimi.it e-mail: giuseppina.guatteri@polimi.it e-mail: anna.paganoni@polimi.it Andrea Ghiglietti Department of Statistical Sciences, Università Cattolica del Sacro Cuore, Largo Gemelli 1, 20123, Milan, Italy e-mail: andrea.ghiglietti@unicatt.it
P o S ( E N A S 6 ) 0 0 7 Improved technique for quasar composite spectra construction

We present a new approach to the composite spectra construct ion based on stacking spectra with similar slopesαλ within the wavelength range redward of Ly α emission line, which allows to reduce the typical noise. With the help of this technique a de t iled study of the HI Lyα-forest region (λrest≈ 1050−1200Å) of the own sample of 3439 medium-resolution quasar sp ectra from SDSS DR7 was performed. More than 14 lines were found within t his wavelength range, three of which were known from previous studies of quasar composit e spectra from SDSS and some others were known in composite spectra from space-based tel scopes or high-resolution spectra of individual quasars from ground-based telescopes.
Determination and Maintenance of Navigation Systems Reference Frames : The EGNOS Example Plag

Satellite-Based Augmentation Systems like the European Geostationary Navigation Overlay Service (EGNOS) provide users with data allowing them to accurately determine their position and integrity parameters. In EGNOS, the GPS and GLONASS observations monitored by Ranging and Integrity Monitoring Stations (RIMS) are transferred to Central Processing Facilities (CPFs) which compute the correction and integrity data. This information is then transmitted to EGNOS users via geostationary satellites. In order to perform the computations, the EGNOS CPFs need accurate and reliable coordinates of the RIMS antennas in a global reference frame with an accuracy of 5 cm. These RIMS coordinates determine the EGNOS reference frame, and users who determine coordinates with the help of EGNOS will get these coordinates in this EGNOS reference frame. Therefore, a key issue is the proper alignment of the EGNOS reference frame with the reference frame(s) commonly used by main EGNOS user groups. Considering aviation as one of the main applications of EGNOS, it is noted here that the ICAO SARPS mandatorily require coordinates to be referred to WGS84. Today, WGS84 as realized by GPS is aligned to the more accurate International Terrestrial Reference Frame (ITRF), and therefore, coordinates with an accuracy of 5 cm in ITRF imply the same accuracy in WGS84. In order to maintain the 5 cm accuracy over time, the RIMS coordinates need to be time-dependent, thus necessitating frequent updates during the anticipated EGNOS lifetime of 15 years. Since EGNOS is a safety-critical element to be used in civil aviation, integrity is a key requirement including also the RIMS coordinates, which have to be associated with a high level of confidence. To meet these requirements, initial geodetic coordinates for 34 EGNOS RIMS were determined in ITRF2000 through dedicated GPS field campaigns. Aligning the EGNOS reference frame to ITRF2000 ensures also a close alignment to WGS84. Reliability of the initial coordinates and their accuracy estimates was achieved through three independent analyses of the observations. The comparison of the independent solutions showed that the accuracy of the mean coordinates is better than 5 cm with respect to ITRF2000. A velocity model for each RIMS station was determined on the basis of a priori information. Maintenance of the coordinates uses the so-called RIMS method, which utilizes the RIMS observations themselves. Three independent analyses of the RIMS observations ensure integrity of the observed coordinates, which are compare to predicted coordinates. The predicted coordinates are computed from the initial coordinates and the velocity model. Only in a few cases, significant deviations between predicted and observed coordinates were detected, which in all cases were due to post-survey changes at the RIMS.
THE BACTERIAL COMMUNITY OF A FRESHWATER SPONGE , RADIOSPONGILLA CEREBELLATA : A COMPARISON OF TERMINAL RESTRICTION FRAGMENT LENGTH POLYMORPHISMS ( T-RFLP ) AND 16 S RRNA CLONE LIBRARY METHODS by

Although most sponges are found in marine environments, some are also found in freshwaters. Sponges harbor diverse communities of sponge-associated bacteria, and the study of the relationship between host sponge and spongeassociated bacteria may demonstrate the existence of symbiotic relationships which benefit both the host sponge and its bacterial symbionts. We examined the bacterial community associated with the freshwater sponge, Radiospongilla cerebellata using terminal restriction fragment length polymorphism (T-RFLP) and Clone Library Construction (CLC) methods. Although T-RFLP allows us to rapidly assess the diversity of the bacterial community associated with freshwater sponges, it does not provide the highest level of taxonomic resolution. However, when T-RFLP results are compared with traditional clone libraries, it is possible to enhance the taxonomic specificity of the T-RFLP method. In this investigation, T-RFLP and CLC analyses demonstrated that there are notable differences between the bacterial community associated with hatched freshwater sponges and that of their intact and crushed gemmules. Freshwater sponges and their gemmules harbor a diverse community of bacteria which varies in its species composition, diversity, and evenness at different stages of their lifecycles. A total
Internationalisation Processes of MBC , Korea

Scholars of the 20 century vigorously attempted to theorise internationalisation of multinational enterprises (MNEs) based on MNEs’ internationalisation processes. As the vast majority of such theories were developed based on descendants of internationalisation processes of manufacturing industry, the validity of theories for the outer manufacturing industry became ambiguous. Despite the fact that one of the fastest growing sectors of global trade since the late 20 century is the trade in cultural/creative industries, scholars haven’t attempted to validate such a phenomenon by reference to existing theories of internationalisation processes. This paper attempts to dismantle the internationalisation processes of a cultural firm and to explore the validity of existing internationalisation theories. Although this paper shows strong support for the dynamic capabilities theory, the theory itself is deficient in explaining the underlying sources and drivers of those environmental factors/forces. In order to overcome such a shortfall, this paper suggests an integrative approach of integrating multidisciplinary theories as a theoretical framework thereby contributing to the under-researched field in the discipline of international business.