Miracle-dz/UniFAR-FTUs huggingface dataset:
Editorial: Mechanisms for the Alteration in the Crosstalk Among Insulin-Sensitive Tissues

Insulin plays a key role in energy homeostasis by exerting anabolic functions in different target (insulin-sensitive) tissues such as skeletal muscle, liver, and adipose tissue (1). Insulin resistance is defined as a shift of the concentration-effect curve towards higher insulin levels, but it is usually also combined with a reduction of the maximal insulin responsiveness (2). In addition to the well-knownmechanisms resulting from an increased caloric intake and decreased physical activity (3), insulin resistance has also recently been shown to be driven by alterations in the crosstalk between different tissues (4, 5). This results frommultiplemetabolites, which not only serve as substrates inmetabolism but also as mediators in metabolic pathways regulating insulin resistance and finally contributing to the onset and evolution of many metabolic diseases encompassing the spectrum of the metabolic syndrome, like obesity, cardiovascular disease (CVD), nonalcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D), etc. (6). Hence, investigating the role of the keyplayers like glucose and its derivatives, lipids, amino acids, and othermetabolites, both in normal aswell as pathologic state, is of primary importance for better characterizing the etiology of many different diseases as well as the development of new and effective therapeutic agents. Here follows the aim of this Research Topic, where the authors contributed with original and review articles aiming to investigate the mechanisms of alteration in metabolic-mediated crosstalk among insulin-sensitive tissues. This was achieved by means of in vitro and/or in vivo animal/ human studies and different methodological techniques, including gene expression, metabolomics, and lipidomics, as well as standard surrogate measurements used in large clinical studies (7). Starting from the original work by Cao et al. the authors investigated the impact of exogenous ATP/ADP/AMP administration on glucose regulation in a mice model, both from a whole-body as well as cellular point of view, by means of metabolomics. In fact, while the excess of intracellular ATP was supposed as a possible risk factor for insulin resistance, little was known about the role of extracellular ATP and its derivatives. With this study, the authors concluded that elevated extracellular ADP levels induce, through direct and indirect mechanisms, the promotion of hepatic gluconeogenesis, and this was also intensified in the context of insulin resistance. In particular, they also found that increased hepatic gluconeogenesis was coupled with elevated NADH levels, possibly representing a marker for the pathogenesis of insulin resistance in the liver. Then, an original work by Qin et al. investigated the role of insulin resistance in the onset of nephrolithiasis and its recurrence. By means of multivariate logistic regressions, the authors found a
Mitogenomes Provide Insights Into the Evolution of Thoracotremata (Brachyura: Eubrachyura)

Thoracotremata is a group of Brachyura, with 1,248 extant species. To date, parts of the thoracotreme phylogeny are not yet resolved and require further investigation. In this study, 12 new mitogenomes from the four thoracotreme superfamilies were sequenced. They contain a standard set of 37 genes, and vary in size from 15,422 (Hapalocarcinus marsupialis Stimpson, 1858 sensu lato) to 16,490 bp [Arcotheres sinensis (Shen, 1932)]. Combined with 58 thoracotreme mitochondrial genomes (mitogenomes) from GenBank, we described the evolution of gene rearrangement and the internal phylogenetic relationships of Thoracotremata, and evaluated the phylogenetic position of Cryptochiroidea and Pinnotheroidea. Nine distinct patterns of mitochondrial gene order (MGO) among thoracotreme mitogenomes are identified, with four MGOs newly found in Thoracotremata. All other gene orders are the result of transformational pathways originating from brachyuran gene order (BraGO). The different gene orders have variable levels of gene rearrangements, which involve both tRNAs and protein-coding genes. No link between variable gene arrangements (breakpoint distances) and nucleotide substitution rates (branch lengths) is found in thoracotreme crabs. The symbiotic groups, the cryptochiroid and pinnotheroid crabs, display variable MGOs (CryGO, Pin1GO, and Pin2GO), providing evidence for possible correlations of rearranged MGOs to the adaptations to specialized lifestyles. In our phylogenetic analyses, Cryptochiridae (Cryptochiroidea) show close relationship with an Ocypodoidea lineage (Camptandriidae/Xenophthalmidae/Dotillidae). Pinnotheridae (Pinnotheroidea) form the basal monophyletic clade.
Photocatalytic Degradation of Rhodamine B Dye and Hydrogen Evolution by Hydrothermally Synthesized NaBH4—Spiked ZnS Nanostructures

Metal sulphides, including zinc sulphide (ZnS), are semiconductor photocatalysts that have been investigated for the photocatalytic degradation of organic pollutants as well as their activity during the hydrogen evolution reaction and water splitting. However, devising ZnS photocatalysts with a high overall quantum efficiency has been a challenge due to the rapid recombination rates of charge carriers. Various strategies, including the control of size and morphology of ZnS nanoparticles, have been proposed to overcome these drawbacks. In this work, ZnS samples with different morphologies were prepared from zinc and sulphur powders via a facile hydrothermal method by varying the amount of sodium borohydride used as a reducing agent. The structural properties of the ZnS nanoparticles were analysed by X-ray diffraction (XRD), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS) techniques. All-electron hybrid density functional theory calculations were employed to elucidate the effect of sulphur and zinc vacancies occurring in the bulk as well as (220) surface on the overall electronic properties and absorption of ZnS. Considerable differences in the defect level positions were observed between the bulk and surface of ZnS while the adsorption of NaBH4 was found to be highly favourable but without any significant effect on the band gap of ZnS. The photocatalytic activity of ZnS was evaluated for the degradation of rhodamine B dye under UV irradiation and hydrogen generation from water. The ZnS nanoparticles photo-catalytically degraded Rhodamine B dye effectively, with the sample containing 0.01 mol NaBH4 being the most efficient. The samples also showed activity for hydrogen evolution, but with less H2 produced compared to when untreated samples of ZnS were used. These findings suggest that ZnS nanoparticles are effective photocatalysts for the degradation of rhodamine B dyes as well as the hydrogen evolution, but rapid recombination of charge carriers remains a factor that needs future optimization.
Predictors of Functional School Outcome in Children With Pediatric Acquired Brain Injury

Objective Among the variety of domains that may be impacted after pediatric acquired brain injury (pABI) are functional school outcomes. The purpose of this study was to identify demographic, medical, and psychological factors associated with impairments in functional school outcomes, defined as school absence, need of educational and psychological services, quality of life (QoL) in the school setting, and academic performance in children with pABI, with a specific emphasis on the significance of fatigue. Materials and Method We used baseline data from a randomized controlled trial. The sample consisted of seventy-six children aged 10 to 17 (M = 13 yrs) with pABI in the chronic phase (>1 year). All completed assessments of school-related QoL, academic performance, global functioning, fatigue, IQ, behavioral problems, and executive function. Results Fatigue, IQ, global functioning, behavioral problems, and sex emerged as potential predictors for functional school outcomes. Of note, overall fatigue emerged as the strongest potential predictor for parent-reported QoL in school (β = 0.548; p < 0.001) and self-reported QoL in school (β = 0.532; p < 0.001). Conclusions Following pABI, specific psychological, medical, and demographic factors are associated with functional school outcomes. Neither of the injury-related variables age at insult and time since insult were associated with functional school outcomes. Overall, our findings may suggest that a reintroduction to school with personalized accommodations tailored to the child's specific function and symptoms, such as fatigue, is recommended.
The place and importance of cultivating sunflower (Helianthus annuus L.) in agriculture enterprises in Turkey: a case study of Thrace region

This study is carried out in the European continent soils of Turkey, namely Thrace Region, which meets the 53% of Turkey’s sunflower ( Helianthus annuus L.) production. In the study, “Stratified Random Sampling Method” has been used and it has been determined that sunflower cultivating area for the enterprises, to which questionnaire was applied, was 5349.75 ha and cultivating area per enterprise was 9.36 ha. In the enterprises investigated wheat took the first place with a proportion of 51.73% of overall cultivating area and sunflower had the second range with the ratio of 42.74%. It has been estimated that enterprises included in the study had a total agricultural income of €15.8 million in 2009. About 86.83% out of their total income was gained from crop production. It was estimated that the ratio of sunflower in the crop production value was 22.71% and in the total agricultural production value was 19.72%. In the examined enterprises average sunflower yield for the year 2009 was 1.770 ton ha -1 , sunflower income was 790.71 € ha -1 and the crop cost was determined as 644.77 € ha -1 . Results of research show that cost of oil, fertilizer and seed comprises 75% cost of sunflower production. The results also indicate that in the cost of sunflower, rise of supporting payments for the oil, fertilizer and seed may reduce the cost of sunflower in Turkey in the future.
Three-Year Outcomes in Kidney Transplant Recipients Switched From Calcineurin Inhibitor-Based Regimens to Belatacept as a Rescue Therapy

Background: The long-term benefits of conversion from calcineurin inhibitors (CNIs) to belatacept in kidney transplant recipients (KTr) are poorly documented. Methods: A single-center retrospective work to study first-time CNI to belatacept conversion as a rescue therapy [eGFR <30 ml/min/1.73 m2, chronic histological lesions, or CNI-induced thrombotic microangiopathy (TMA)]. Patient and kidney allograft survivals, eGFR, severe adverse events, donor-specific antibodies (DSA), and histological data were recorded over 36 months after conversion. Results: We included N = 115 KTr. The leading cause for switching was chronic histological lesions with non-optimal eGFR (56.5%). Three years after conversion, patient, and death-censored kidney allograft survivals were 88% and 92%, respectively, eGFR increased significantly from 31.5 ± 17.5 to 36.7 ± 15.7 ml/min/1.73 m2 (p < 0.01), the rejection rate was 10.4%, OI incidence was 5.2 (2.9–7.6) per 100 person-years. Older age was associated with death, eGFR was not associated with death nor allograft loss. No patient developed dnDSA at M36 after conversion. CNI-induced TMA disappeared in all cases without eculizumab use. Microvascular inflammation and chronic lesions remained stable. Conclusion: Post-KT conversion from CNIs to belatacept, as rescue therapy, is safe and beneficial irrespective of the switch timing and could represent a good compromise facing organ shortage. Age and eGFR at conversion should be considered in the decision whether to switch. Graphical Abstract
Quantitative Extraction and Evaluation of Tomato Fruit Phenotypes Based on Image Recognition

Tomato fruit phenotypes are important agronomic traits in tomato breeding as a reference index. The traditional measurement methods based on manual observation, however, limit the high-throughput data collection of tomato fruit morphologies. In this study, fruits of 10 different tomato cultivars with considerable differences in fruit color, size, and other morphological characters were selected as samples. Constant illumination condition was applied to take images of the selected tomato fruit samples. Based on image recognition, automated methods for measuring color and size indicators of tomato fruit phenotypes were proposed. A deep learning model based on Mask Region-Convolutional Neural Network (R-CNN) was trained and tested to analyze the internal structure indicators of tomato fruit. The results revealed that the combined use of these methods can extract various important fruit phenotypes of tomato, including fruit color, horizontal and vertical diameters, top and navel angles, locule number, and pericarp thickness, automatically. Considering several corrections of missing and wrong segmentation cases in practice, the average precision of the deep learning model is more than 0.95 in practice. This suggests a promising locule segmentation and counting performance. Vertical/horizontal ratio (fruit shape index) and locule area proportion were also calculated based on the data collected here. The measurement precision was comparable to manual operation, and the measurement efficiency was highly improved. The results of this study will provide a new option for more accurate and efficient tomato fruit phenotyping, which can effectively avoid artificial error and increase the support efficiency of relevant data in the future breeding work of tomato and other fruit crops.
Sport Community Involvement and Life Satisfaction During COVID-19: A Moderated Mediation of Psychological Capital by Distress and Generation Z

How can sport community involvement influence life satisfaction during a pandemic? Self-expansion theory posits that individuals seek to gain resources such as positive interpersonal relationships for growth and achievement. By considering psychological capital (PsyCap) as a dispositional resource intervening between sport community involvement and life satisfaction, we examined an empirical model to test the chain of effects. Based on the stress process model, distress and generational group (Generation Z vs. others) were tested as moderators. Participants (N = 233) responded to the scale item questionnaire for model assessment. Supporting the hypothesized relationships, the model was supported with a significant moderated-moderated mediation. The mediation effect of PsyCap was stronger when distress level was lower and such interaction effect was amplified for Generation Z (Gen Z). Whereas the global sport communities and Gen Z were found to be more particularly vulnerable to COVID-19, our findings suggest that there are psychological pathways for fans to maintain their resilience. It is foremost imperative to lower the stress level of sport fans for their community involvement to positively affect life satisfaction. Gen Z were more stressed during the pandemic but individuals who managed to cope with stress were able to leverage community involvement to boost positive psychological resources. Acknowledgment of these effects brings implications for better management strategies and provides avenues for new research.
Towards User-Centred Prosthetics Research Beyond the Laboratory

The purpose of this study was to explore a range of perspectives on how academic research and clinical assessment of upper-limb prosthetics could happen in environments outside of laboratories and clinics, such as within peoples’ homes. Two co-creation workshops were held, which included people who use upper limb prosthetic devices (hereafter called users), clinicians, academics, a policy stakeholder, and a representative from the upper-limb prosthetics industry (hereafter called professionals). The discussions during the workshops indicate that research and clinical assessment conducted remotely from a laboratory or clinic could inform future solutions that address user needs. Users were open to the idea of sharing sensor and contextual data from within their homes to external laboratories during research studies. However, this was dependent upon several considerations, such as choice and control over data collection. Regarding clinical assessment, users had reservations of how data may be used to inform future prosthetic prescriptions whilst, clinicians were concerned with resource implications and capacity to process user data. The paper presents findings of the discussions shared by participants during both workshops. The paper concludes with a conjecture that collecting sensor and contextual data from users within their home environment will contribute towards literature within the field, and potentially inform future care policies for upper limb prosthetics. The involvement of users during such studies will be critical and can be enabled via a co-creation approach. In the short term, this may be achieved through academic research studies, which may in the long term inform a framework for clinical in-home trials and clinical remote assessment.
SCLC Treatment in the Immuno-Oncology Era: Current Evidence and Unmet Needs

Small cell lung cancer (SCLC) represents about 13%–15% of all lung cancers. It has a particularly unfavorable prognosis and in about 70% of cases occurs in the advanced stage (extended disease). Three phase III studies tested the combination of immunotherapy (atezolizumab, durvalumab with or without tremelimumab, and pembrolizumab) with double platinum chemotherapy, with practice-changing results. However, despite the high tumor mutational load and the chronic pro-inflammatory state induced by prolonged exposure to cigarette smoke, the benefit observed with immunotherapy is very modest and most patients experience disease recurrence. Unfortunately, biological, clinical, or molecular factors that can predict this risk have not yet been identified. Thanks to these clinically meaningful steps forward, SCLC is no longer considered an “orphan” disease. Innovative treatment strategies and combinations are currently under investigation to further improve the expected prognosis of patients with SCLC. Following the recent therapeutic innovations, we have reviewed the available literature data about SCLC management, with a focus on current unmet needs and potential predictive factors. In detail, the role of radiotherapy; fragile populations, such as elderly or low-performance status patients (ECOG PS 2), usually excluded from randomized studies; predictive factors of response useful to optimize and guide therapeutic choices; and new molecular targets and future combinations have been explored and revised.
Feasibility for Using Thermography Throughout an Exercise Program in Mastectomized Patients

Introduction Breast cancer is the most common in the female population. Physical training is safe and indicated after surgical treatment for breast cancer. During exercise, body temperature changes due to tissue metabolic activity; in this sense, infrared thermography is used to map the thermal patterns of the body surface. Objective This study aimed to evaluate the feasibility of using thermography during a physical rehabilitation program in mastectomized patients by analyzing the change in body temperature caused by physical exercise in the breast region. Methodology This is a simple and covert clinical trial, in which the sample was constituted for convenience. The women were submitted to a supervised physical exercise protocol, three times a week, for 20 sessions. They were evaluated in the first, tenth, and twentieth sessions in relation to changes in body temperature in the breast region (infrared thermography). Results Twenty patients who underwent mastectomy surgery were recruited. No patient had drain infection, scar dehiscence, or lymphedema, and only one patient had seroma removed. The mean age was 50.45 ± 2.00 years, and the body mass index (BMI) was 28.95 ± 1.11 kg/m2. In the body thermography of the patients’ breast region, no significant difference was observed when comparing the thermograms of the plastron region of the patients in the first, tenth, and twentieth sessions (p = 0.201). However, when comparing the plastron region with the control breast, a reduction in temperature was observed in the operated region in the first (p = 0.012) and tenth sessions (p = 0.004). Conclusion Through this study, we can conclude that the use of infrared thermography is viable for the analysis of the body temperature of mastectomized patients during a supervised physical exercise protocol and, therefore, suggest that this instrument is increasingly used in the cancer public.
Superalkali Coated Rydberg Molecules

A series of complexes of Na, K, NH4, and H3O with [bpy.bpy. bpy]cryptand, [2.2. 2]cryptand, and spherical cryptand were investigated via DFT and ab initio methods. We found that by coating Rydberg molecules with the “organic skin” one could further decrease their ionization potential energy, reaching the values of ∼1.5 eV and a new low record of 1.3 eV. The neutral cryptand complexes in this sense possess a weakly bounded electron and may be considered as very strong reducing agents. Moreover, the presence of an organic cage increases the thermodynamic stability of Rydberg molecules making them stable toward the proton detachment.
Physiological Responses of Typical Wetland Plants Following Flooding Process—From an Eco-Hydrological Model Perspective

Anaerobics increase resistance to gas transport and microbial activity in flooded soils. This may result in the presence of aerenchyma in the roots of some wetland plants. Increased aerenchyma airspaces enable oxygen to be transported from the above-ground plant parts to the submerged roots and rhizosphere. Nevertheless, there is still a lack of studies linking field experiments and eco-hydrological modeling to the parameterization of the physiological responses of typical wetland plant species to natural flooding events. Furthermore, from the modeling perspective, the contribution of aerenchyma was not sufficiently considered. The goal of this study was to develop and apply an eco-hydrological model capable of simulating various patterns of plant physiological responses to natural flooding events based on key processes of root oxygen diffusion and aerenchyma functioning in a variably-saturated wetland soil environment. Eco-hydrological experiments were conducted accordingly, with surface water level, root-zone soil water content, soil temperature, leaf net photosynthesis rate and root morphology monitored simultaneously in situ at a site dominated by meadow species Deyeuxia angustifolia (Kom.) Y. L. Chang and invaded shrub species Salix rosmarinifolia Linn. var. brachypoda (Trautv.et Mey.) Y.L. Chou in a typical natural floodplain wetland. The results are as follows: (1) Root oxygen respiration rates are strongly correlated with leaf net photosynthesis rates of the two plant types, particularly under flooding conditions during the growing season; (2) Meadow species with a preference for wet microhabitats has a competitive advantage over first-year invading shrub species during flooding events; and (3) an aerenchyma sub-model could improve the eco-hydrological model’s accuracy in capturing plant physiological responses. These findings have the potential to contribute to the management of wetland and its restorations.