Miracle-dz/UniFAR-FTUs huggingface dataset:
BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF GUAIFENESIN IN HUMAN PLASMA BY LIQUID CHROMATOGRAPHY COUPLED WITH TANDEM MASS SPECTROSCOPY

A rapid, sensitive and simple liquid chromatography tandem mass spectrometry (LCMS/MS) method has been developed and validated for quantification of guaifenesin in human plasma. The analyte was extracted from human plasma by liquid-liquid extraction (LLE) technique. Glibenclamide was used as the internal standard. A Kromosil C18 column provided chromatographic separation of the analyte which was followed by detection with tandem mass spectrometry. The mass transition ion–pair was followed as m/z 163.000 for Guaifenesin and m/z 368.968 for Glibenclamide. The method involved liquid-liquid extraction of Guaifenesin from plasma by using sample preparation LLE column C18 (150mm x 4.6mm., 5μ.,) followed that simple isocratic chromatographic conditions with mobile phase of methanol: 0.1% formic acid (90:10%v/v) and tandem mass spectrometric detection that enables detection nano-gram levels. The retention times were 1.05 and 1.49 minutes for guaifenesin and Glibenclamide respectively. The proposed method has been validated with linear range 23.966 to 6001.154 ng/mL for guaifenesin. The precision and accuracy values are within 5%. The overall recovery of guaifenesin was 102.83%.
An imaging-plate detector for small-angle neutron scattering

Small-angle neutron scattering (SANS) measurements have been performed on long-flight-path pinhole-collimation SANS instruments using, as a two-dimensional position-sensitive detector, both a neutron imaging plate, incorporating gadolinium, and a two-step transfer method, with dysprosium foil as the image transfer medium. The measurements are compared with corresponding data taken using conventional position-sensitive gas proportional counters on the SANS instruments in order to assess the viability of the imaging techniques. The imaging plates have pixel sizes of about two orders of magnitude smaller than those of the gas proportional counter. The reduced pixel size provides definite advantages over the gas counter in certain specific situations, namely when limited space necessitates a short sample-to-detector distance, when only small samples (comparable in size to the detector pixels) are available, or when used in conjunction with focusing beam optics.
University ’ s repository of research publications and other research outputs Understanding the Roots of Radicalisation on Twitter Conference or Workshop Item

In an increasingly digital world, identifying signs of online extremism sits at the top of the priority list for counter-extremist agencies.1 Researchers and governments are investing in the creation of advanced information technologies to identify and counter extremism through intelligent large-scale analysis of online data. However, to the best of our knowledge, these technologies are neither based on, nor do they take advantage of, the existing theories and studies of radicalisation. In this paper we propose a computational approach for detecting and predicting the radicalisation influence a user is exposed to, grounded on the notion of ’roots of radicalisation’ from social science models. This approach has been applied to analyse and compare the radicalisation level of 112 pro-ISIS vs.112 “general" Twitter users. Our results show the effectiveness of our proposed algorithms in detecting and predicting radicalisation influence, obtaining up to 0.9 F-1 measure for detection and between 0.7 and 0.8 precision for prediction. While this is an initial attempt towards the effective combination of social and computational perspectives, more work is needed to bridge these disciplines, and to build on their strengths to target the problem of online radicalisation.
LARCH ( LARIX GMELINII ) BULK SOIL PHENOLIC ACIDS PROMOTE MANCHURIAN WALNUT ( JUGLANS MANSHURICA ) GROWTH AND SOILMICROORGANISM BIOMASS

The current study investigated the effect of seasonal variation on larch root exudates and the impact of some phenolic acids allelopathic on soil microbes and seedling growth. The soil microbial profiles were determined by phospholipid fatty acids (PLFA) digest method, whereas phenolic acids identification and their concentration in larch rhizosphere and bulk soil was determined by HPLC during spring, summer and autumn 2011. Combinations of four phenolic acids concentration (2, 4-2 hydroxy acid, 7-hydroxy coumarin, ferulic acid and abietic acids) were added to Manchurian walnut seedling pot soil and their PLFA profile and seedling biomass was measured after seedling harvest. Results indicated that seasonal variation of larch total root exudates was highest in soil in autumn and summer than spring . Bulk phenolic acids exerted stimulation effect on the microbial biomass and Manchurian seedling biomass. The rhizosphere soil phenolic acids had a negative impact on the microbial biomass and seedling growth due to high phenolic acids concentration. Principal component analysis explained 63.6% and 65.5% of total variation in PLFA composition in larch rhizosphere and bulk soil. Thus, bulk soil phenolic acid combination, particularly 7-hydroxyl coumarin + ferulic acid, has considerable stimulative impact on seedling and microbial biomass.
Title Balancing influence between actors in healthcare decision making Permalink

Background: Healthcare costs in most developed countries are not clearly linked to better patient and public health outcomes, but are rather associated with service delivery orientation. In the U.S. this has resulted in large variation in healthcare availability and use, increased cost, reduced employer participation in health insurance programs, and reduced overall population health outcomes. Recent U.S. healthcare reform legislation addresses only some of these issues. Other countries face similar healthcare issues. Discussion: A major goal of healthcare is to enhance patient health outcomes. This objective is not realized in many countries because incentives and structures are currently not aligned for maximizing population health. The misalignment occurs because of the competing interests between “actors” in healthcare. In a simplified model these are individuals motivated to enhance their own health; enterprises (including a mix of nonprofit, for profit and government providers, payers, and suppliers, etc.) motivated by profit, political, organizational and other forces; and government which often acts in the conflicting roles of a healthcare payer and provider in addition to its role as the representative and protector of the people. An imbalance exists between the actors, due to the resources and information control of the enterprise and government actors relative to the individual and the public. Failure to use effective preventive interventions is perhaps the best example of the misalignment of incentives. We consider the current Pareto efficient balance between the actors in relation to the Pareto frontier, and show that a significant change in the healthcare market requires major changes in the utilities of the enterprise and government actors. Summary: A variety of actions are necessary for maximizing population health within the constraints of available resources and the current balance between the actors. These actions include improved transparency of all aspects of medical decision making, greater involvement of patients in shared medical decision making, greater oversight of guideline development and coverage decisions, limitations on direct to consumer advertising, and the need for an enhanced role of the government as the public advocate.
3D BUILDINGS EXTRACTION FROM AERIAL IMAGES

This paper introduces a semi-automatic method for buildings extraction through multiple-view aerial image analysis. The advantage of the used semi-automatic approach is that it allows processing of each building individually finding the parameters of buildings features extraction more precisely for each area. On the early stage the presented technique uses an extraction of line segments that is done only inside of areas specified manually. The rooftop hypothesis is used further to determine a subset of quadrangles, which could form building roofs from a set of extracted lines and corners obtained on the previous stage. After collecting of all potential roof shapes in all images overlaps, the epipolar geometry is applied to find matching between images. This allows to make an accurate selection of building roofs removing false-positive ones and to identify their global 3D coordinates given camera internal parameters and coordinates. The last step of the image matching is based on geometrical constraints in contrast to traditional correlation. The correlation is applied only in some highly restricted areas in order to find coordinates more precisely, in such a way significantly reducing processing time of the algorithm. The algorithm has been tested on a set of Milan's aerial images and shows highly accurate results.
Synthesis, Characterization and Antimicrobial Activity of Some Organotin (IV) Complexes with a Potassium Hydrogen Ethanedioate Ligand

Four series of organotin (IV) derivatives of potassium hydrogen ethanedioate: Bu2SnL2, Bu3SnL, Ph2SnL2 and Ph3SnL have been synthesized characterized by tin content analysis, FTIR, 1H NMR and 13C NMR and tested for antimicrobial activity against four Gram-positive bacteria: Staphylococcus aureus, Streptococcus pyogenes, Bacillus cereus, Corynebacterium ulcerans, four Gramnegative Bacteria: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis and Pseudomonas aeruginosa and four fungi strains of Microsporum spp:Microsporum audounii, Microsporum distortum, Microsporum gallinae and Microsporum gypseum. Result showed that the compounds synthesized in general exhibited greater antimicrobial activity than potassium hydrogen ethanedioate. Organotin moieties play a vital role in deciding the antimicrobial activity of an organotin compound, this is true in this work. The order for the antifungal activity in this study was Bu3SnL > Ph3SnL >Ph2SnL2> Bu2SnL2. The order of activity against gram-positive bacteria was Ph3SnL > Bu2SnL2> Ph2SnL2> Bu3SnL. The order of activity against gram-negative bacteria was Bu3SnL > Bu2SnL2> Ph2SnL2> Ph3SnL.
Infrared spectroscopy of asymptotic giant branch stars in the Galactic bulge

We have selected a homogeneous sample of asymptotic giant branch (AGB) stars in the Galactic bulge population from the ISOGAL survey. Our target stars cover a wide range of mass-loss rates (∼10−8-10−4 M⊙ yr−1) and differ primarily by their age on the AGB. This homogeneous sample is thus ideally suited to study the dust formation process as a function of age on the AGB. We observed our sample with Spitzer-Infrared Spectrograph, and studied the overall properties of the infrared spectra of these targets. The analysis is complicated by the presence of strong and variable background emission, and the extracted infrared AGB star spectra are affected by interstellar extinction. Several stars in our sample have no detectable dust emission, and we used these ‘naked stars’ to characterize the stellar and molecular contributions to the infrared spectra of our target stars. The resulting dust spectra of our targets do indeed show significant variety in their spectral appearance, pointing to differing dust compositions for the targets. We classify the spectra based on the shape of their 10-μm emission following the scheme by Sloan & Price. We find that the early silicate emission classes associated with oxide dust are generally under-represented in our sample due to extinction effects. We also find a weak 13-μm dust feature in two of our otherwise naked star spectra, suggesting that the carrier of this feature could potentially be the first condensate in the sequence of dust condensation.
Artificial Neural Network ( ANN ) based novel Performance evaluation technique

In this study we have highlighted different performance evaluation techniques in order to carry out adequate performance based appraisal of employees working in different organisations. The paper briefly describes and compares both traditional as well as several modern Performance appraisal techniques which are currently in practice. In this study we have proposed a new soft-computing based appraisal technique which works by combining learning ability of artificial neural networks and reasoning capability of fuzzy logic theory. The results are validated by comparing working of proposed approach to conventional average based rating technique. The results further confirmed appropriateness of above mentioned technique over other traditional appraisal approaches.
SURFACE MICROTOPOGRAPHY OF ILLITE CRYSTALS FROM DIFFERENT MODES OF OCCURRENCE

By mea.ns of ransmission electron microscopy (IEM) and the gold-decoration technique, the surface microtopography of illite crystals from various environments was investigated. On the crystal surfaces, gold decoration successfully re""al"d gro-wtlt steps of -1 nm in height. The illite samples investigated exclusively exhibit gro*th spirals of either polygonal or circular form, with varying separation of steps. The spiral morphological characteristics were critically analyzed in retation to theirmode of occurence. Crystals fre6 massive metasomatic specimens (aggregation textrue with very low porosity) are characteizeAby circulargrot+th-spirals with a narrow separation of steps, whereas those from veins and dhses (aggregation texture with higir porosity) arg cl.arlcterized by polygonal growth-spirals with a wide separation of steps. Hexagonal ald lath-shaped crystals were controlled tiY polygonal spiral-growth; on the other hand, irregular plary crystals are characterized by circuliar or malformed circular spiral-grovth. The morphology of illite crystals seems to reflect the spiral-growth process under the various conditions.
BRAF Gene Mutation Testing to Select Melanoma or Glioma Patients for Targeted Therapy

GENETICS NOMENCLATURE UPDATE Human Genome Variation Society (HGVS) nomenclature is used to report information on variants found in DNA and serves as an international standard in DNA diagnostics. It is being implemented for genetic testing medical evidence review updates starting in 2017 (see Table PG1). HGVS nomenclature is recommended by HGVS, the Human Variome Project, and the HUman Genome Organization (HUGO).
Finding Humour in the Blogosphere: The Role of WordNet Resources

Humour is an amazing and challenging topic. Despite the several analyses and researches for understanding its complex mechanisms, it is not completely defined. The studies performed from the Natural Language Processing perspective have demonstrated that, taking into account linguistic resources, statistical methods, machine learning and corpus-based techniques, humour may be handled by means of computational systems in order to automatically generate and recognise it. In this paper we focused on studying humour in the blogosphere. The aim is to evaluate the importance of lexical resources linked to WordNet for recognising blogs with greater probability to contain humour. All the experiments were performed over a corpus integrated by 19,200 blogs. Moreover, a corpus of 16,000 humorous one-liners was used in order to evaluate our results. The findings are encouraging.
Expression and prognostic significance of hsa-miR-1423 p in acute leukemias

Objectives: The microRNA 142 (miR-142) is expressed at high levels in mature hematopoietic cells and has a crucial role during T-lymphocyte development. Its role in leukemogenesis is unclear. Patients and methods: Expression of miR-142 was analyzed in acute myeloid and lymphoblastic leukemia cells (de novo, cell lines). Data were compared to expression in CD34+ hematopoietic cells. Based on the miR-142 expression, clinical data such as overall survival was analyzed. Results: MiR-142 expression in all leukemia cell lines and 86 % of the de novo samples was higher than in CD34+ cells. This difference could be detected in both, myeloid and lymphoid neoplastic cells. In AML patients with intermediate cytogenetic risk a high miR-142 expression was associated with a better overall survival. Conclusions: MiR-142 expression in acute lymphoblastic as well as myeloid leukemia cells is higher than in CD34+ cells. Additionally, miR-142 expression might have prognostic relevance in AML-patients with otherwise an intermediate cytogenetic risk.
Highly Scalable , Dynamic , and Robust Routing Scheme based on Virtual Space Representation

-This only looks like the abstract. A novel routing scheme based on Virtual Space (VS) configuration is presented here for use in high-speed packet networks. This paper presents a comprehensive treatment of the VS routing scheme, including its logical development, formulation, simulated performance analysis, and implementation. First, the VS embedding process transforms the network topology information into a multidimensional virtual space representation. The VS configuration of the network is a highly concise representation, which has excellent directionality property to enable simple geometric routing. Dynamic changes in link conditions and traffic loading states are expressed using link costs to enable fast adaptability and failure recovery. Thus, the VS routing scheme is highly scalable, dynamic, robust, and simple to implement. Performance of VS routing is simulated for small networks with just 25 nodes to large networks with over 1000 nodes having arbitrary connection topologies. The simulations demonstrate high packet throughput of over 99.9% with low probability of looping paths. The throughput remains over 99% even under failure of 10% links in the network. It demonstrates the robustness and self-healing property of the VS routing scheme. This paper presents an implementation scheme for constructing a VS routing domain that is compatible with IP networks. It describes routing and forwarding functionalities of VS domain and routing nodes. It further addresses applications of VS routing scheme to build overlay tools to enhance performance and functionality of existing networks.
A Re-Evaluation of the Morphology of a Bicontinuous Block Copolymer−Ceramic Material

The structures of a poly(isoprene-block-ethylene oxide) (PI-b-PEO) block copolymer-directed aluminosilicate mesostructure and the resulting ceramic material obtained from calcination were studied via small-angle X-ray scattering (SAXS) and transmission electron microscopy (TEM). The PI minority phase (volume fraction 0.36) formed a continuous network of channels, previously reported1,2 to be consistent with the plumber's nightmare3 morphology. The solvent casting process used to form the material caused it to shrink uniaxially by ∼30%, deforming the network structure within it. Calculated structure factors for constant-curvature and constant-thickness models of a distorted double gyroid structure are consistent with SAXS from the material, while [100] and [111] projections of the distorted double gyroid structure match the TEM data. Because the structural data from the material is most consistent with a distorted version of the double gyroid morphology, the previous assignment of the plumber's nightmare m.
emporal stability and psychological foundations of cooperation

A core element of economic theory is the assumption of stable preferences. We test this assumption in public goods games by repeatedly eliciting cooperation preferences in a fixed subject pool over a period of five months. We find that cooperation preferences are very stable at the aggregate level, and, to a smaller degree, at the individual level, allowing us to predict future behavior fairly accurately. Furthermore, our results provide evidence on the psychological foundations of cooperation preferences. The personality dimension ‘Agreeableness’ is closely related to both the type and the stability of cooperation preferences. © 2011 Elsevier B.V. All rights reserved.
ANTIBIOTIC SUSCEPTIBILITY PATTERNS OF ISOLATED BACTERIA FROM BILE FLUIDS OF PATIENTS WITH GALLSTONE DISEASE IN ISFAHAN CITY (IRAN)

Bacterial infections are one of the important agents in the creation of gallstones in the gallbladder. In recent years the spread of antibiotic-resistant bacteria such as extended-spectrum beta-lactamases (ESBL) is increasing and of concern in hospitalized patients worldwide. The purpose of this study was to investigate the antibiotic susceptibility patterns of isolated bacteria from the bile specimens of patients with chronic and acute cholecystitis who had been operated by single-incision laparoscopic cholecystectomy (SILC) in Isfahan (Iran) using an antibiogram susceptibility test and molecular technique. The bile fluids of 91 patients were obtained from the Al-Zahra hospital and were cultured on specific media for the isolation of Gram-negative and positive bacteria and the disk diffusion test was done to determine the antibiotic susceptibility patterns of isolated bacteria. Finally, bacterial DNA was extracted from the bile samples and polymerase chain reaction (PCR) was performed to investigate extended-spectrum beta-lactamases genes. The bacteria Escherichia coli, Klebsiella pneumoniae, Proteus spp. and Staphylococcus aureus were detected in bile specimens cultured with high frequency, and the results showed that biliary infection increased with aging in patients with gallstone disease operated by SILC. The results showed a high frequency of ESBL genes including TEM, SHV, and CTX-M in isolated bacteria (especially Escherichia coli and Klebsiella spp.). Thus, evaluating the antibiotic susceptibility patterns and screening of ESBLs bacteria in patients with gallstones are essential. Prescribing suitable drugs, designing good strategies, and informing the medical community could decrease bile infection and antibiotic-resistant bacteria in clinical centers and hospitals.
Soil Moisture in the Biebrza Wetlands Retrieved from Sentinel-1 Imagery

The objective of the study was to estimate soil moisture (SM) from Sentinel-1 (S-1) satellite images acquired over wetlands. The study was carried out during the years 2015–2017 in the Biebrza Wetlands, situated in north-eastern Poland. At the Biebrza Wetlands, two Sentinel-1 validation sites were established, covering grassland and marshland biomes, where a network of 18 stations for soil moisture measurement was deployed. The sites were funded by the European Space Agency (ESA), and the collected measurements are available through the International Soil Moisture Network (ISMN). The SAR data of the Sentinel-1 satellite with VH (vertical transmit and horizontal receive) and VV (vertical transmit and vertical receive) polarization were applied to SM retrieval for a broad range of vegetation and soil moisture conditions. The methodology is based on research into the effect of vegetation on backscatter (σ°) changes under different soil moisture and Normalized Difference Vegetation Index (NDVI) values. The NDVI was derived from the optical imagery of a MODIS (Moderate Resolution Imaging Spectroradiometer) sensor onboard the Terra satellite. It was found that the state of the vegetation expressed by NDVI can be described by the indices such as the difference between σ° VH and VV, or the ratio of σ° VV/VH, as calculated from the Sentinel-1 images in the logarithmic domain. The most significant correlation coefficient for soil moisture was found for data that was acquired from the ascending tracks of the Sentinel-1 satellite, characterized by the lowest incidence angle, and SM at a depth of 5 cm. The study demonstrated that the use of the inversion approach, which was applied to the newly developed models using Water Cloud Model (WCM) that includes the derived indices based on S-1, allowed the estimation of SM for wetlands with reasonable accuracy (10 vol. %). The developed soil moisture retrieval algorithms based on S-1 data are suited for wetland ecosystems, where soil moisture values are several times higher than in agricultural areas.