Miracle-dz/UniFAR-FTUs huggingface dataset:
The relationship between maternal reflexive functions and joint attention in neurotypical children.

The 20th century witnessed tremendous breakthroughs in medical research by virtue of a plethora of discoveries and advances in fundamental biology and disease management. The 21st century is taking medicine to unprecedented heights. Clinical research sponsored by a flourishing industry shaped our understanding of modern medicine. However, industry funded clinical research cannot answer all medical questions. In this review, we look at the growing impetus on investigator initiated studies, their impact on deeper understanding of real world needs, involvement of pharmaceutical, devices and imaging industry in supporting investigator or institution initiated research and instances of such successful endeavours that has changed the way medicine is practised. We also delve into the changing landscape of clinical research ecosystem in the light of recent advances in technologies like genomics, biologics, companion diagnostics and precision medicine system and the urgent need of creating and supporting a culture of research among individual clinicians, institutions, public and Government bodies in alleviating global disease burden. We recommend structural and functional models of association between the industry and investigator initiated research in order to overcome the traditional challenges of such research and pave the way for a fruitful and collaborative approach towards inclusive and comprehensive patient centric disease management.
Relationship of obstructive sleep apnea with oxygen consumption, physical activity, and diet

Objective: To evaluate the maximum oxygen consumption (VO2max), physical activity level, food consumption and quality of life in patients with obstructive sleep apnea (OSA). Methods: Descriptive qualitative and quantitative study with cross-sectional analysis based on the application of structured questionnaires, carried out in a private clinic at Petrolina, PE, Brazil. Quality of life was assessed by the WHOQOL-bref, food consumption using the form of food consumption markers contained in the SISVAN Protocol, and the level of physical activity by the IPAQ short version. Results: Of the 16 included patients, 6 had no OSA, 4 had mild OSA, 2 had moderate OSA, and 4 had severe OSA. Sedentary lifestyle was prevalent in 20% of the patients with mild OSA, in 50% of those with moderate OSA and in 75% of those with severe OSA. Healthy food consumption prevailed in all groups, with a higher consumption of unhealthy foods in the severe OSA group. A predominance of regular quality of life was identified in all groups, especially needing to improve the physical domain of all of them. Both VO2max and the anaerobic threshold showed reduced values as the severity of the disease increased, with lower values in patients with the most severe form of the disease. Conclusion: An inverse relationship was found between more severe OSA with VO2max and the levels of physical activity of the patients analyzed. There is a greater consumption of unhealthy foods with poor diet and sedentary behavior that are important risk factors for the development and worsening of the disease.
Bio-based graphene/sodium alginate aerogels for strain sensors

Highly flexible strain sensors based on graphene aerogels (GAs) have been widely researched. However, most GAs are often found to be extremely weak and delicate to handle due to the π–π stacking and van der Waals interactions between adjacent graphene sheets that lead to a brittle skeleton. Thus constructing graphene structures with excellent mechanical properties, high sensitivity and effective conductive networks is still a big challenge. In this work, we fabricate a bio-based graphene/sodium alginate aerogel with high porosity (99.61%) and low density (6–7 mg cm−3) via freeze drying and chemical reduction. The resulting aerogels exhibit outstanding durability (>6000 loading–unloading cycles), excellent sensitivity to compression (gauge factor is 1.01) and bending (bending sensitivity is 0.172 rad−1). The strong hydrogen bonding interactions between graphene and SA are responsible for the synergetic enhancement of strength and elasticity. Taking advantage of the combination of the electronic conductivity and mechanical flexibility, the proposed bio-based aerogels may be a robust candidate in flexible strain sensors.
Predicting the Visibility of the First Crescent

This study presents an application of machine learning to predict whether the first crescent of the lunar month will be visible to naked eye on a given date. The study presents a dataset of successful and unsuccessful attempts to find the first crescent at the start of the lunar month. Previously, this problem was solved by analytically deriving the equations for visibility parameter(s) and manually fixing threshold values. However, we applied supervised machine learning on the independent variables of the problem, and the system learnt about the criteria of classification. The system gives precision of 0.88 and recall of 0.87 and hence it treats both false positives and false negatives equally well.
FERTILITY RESTORATION OF THE PET1 CYTOPLASM AND OTHER CMS SOURCES IN THE GENUS HELIANTHUS

Restorer genes involved in fertility restoration of the PET1, PEF1 and PET2 cytoplasms were investigated. In a map-based cloning approach to isolate the restorer gene Rf1 of the PET1 cytoplasm in sunflower tightly linked markers were identified. Bulked segregant analyses using 1200 decamer primers identified seven RAPD markers mapping in the same linkage group as the restorer gene Rf1. In our segregating population of the cross RHA 325 (CMS) x HA342 (F2 population,183 individuals) one of the RAPD markers, OP-K13_454, mapped 0.9 cM from Rf1, followed by OP-Y10_740 with 2.2 cM. Screening 1024 AFLP primer combinations by bulked segregant analyses detected 282 polymorphisms in 203 primer combinations. On the linkage group carrying the restorer gene Rf1, 43 markers (7 RAPD-, 1 SSR-, and 35 AFLP-markers) were mapped that covered 250.3 cM. Three new AFLP markers, E32M36_155, E44M70_275 and E42M76_125 were mapped with 0.7 cM, 0.1 cM and 0.2 cM from the restorer gene. Two of the RAPD markers, OP-K13_454 and OP-Y10_740, were successfully converted into SCAR markers. A CAPS marker was developed from the RAPD marker OP-H13_337. For analysis of the genome organization around the restorer gene Rf1, BAC clones were identified by colony hybridization and 3D-PCR pooling strategies. BAC fingerprinting using different restriction enzymes in combination with hybridization was performed to develop a contig around the restorer locus Rf1. AFLP polymorphic primer combinations in the cross RHA 325 (CMS) x HA 342 were also tested in bulked segregant analyses of populations segregating for fertility restoration of PEF1 and PET2.
Method for estimating the depth of circulation of thermal and non-thermal waters in the upper crust

In this work we consider model formulations that allow better understandings of the relations between Darcy velocity and temperatures in coupled two-dimensional systems. The revised theoretical formulations are capable of accounting for the effects of heat transfer by fluid movements in horizontal and vertical directions. The models have been found useful in estimating the maximum and minimum depths of thermal and non-thermal waters in several geological units in Brazil. The best fitting values encountered are 1.8 to 2.7 km for the Parana basin, 2.0 to 2.8 km for the Parnaiba basin, 1.6 to 2.3 km for the Amazon basins, 2.0 to 2.7 km for the San Francisco Province, 1.9 to 2.4 km for the Sergipe-Alagoas basins and 2.0 to 2.8 km for the Borborema Province. The models have also allowed estimation the average values of Peclet number and Darcy velocity for groundwater flows in these units. Note that higher horizontal velocities are associated with smaller depths of circulation. This is a natural consequence of the fact that in systems where horizontal velocities are high the quantities of vertical flows are less intense.
NtFuzz: Enabling Type-Aware Kernel Fuzzing on Windows with Static Binary Analysis

Although it is common practice for kernel fuzzers to leverage type information of system calls, current Windows kernel fuzzers do not follow the practice as most system calls are private and largely undocumented. In this paper, we present a practical static binary analyzer that automatically infers system call types on Windows at scale. We incorporate our analyzer to NtFuzz, a type-aware Windows kernel fuzzing framework. To our knowledge, this is the first practical fuzzing system that utilizes scalable binary analysis on a COTS OS. With NtFuzz, we found 11 previously unknown kernel bugs, and earned $25,000 through the bug bounty program offered by Microsoft. All these results confirm the practicality of our system as a kernel fuzzer.
The protective effect of p-coumaric acid on toluene-induced hepatotoxicity, nephrotoxicity and neurotoxicity in rats

Objective. The aim of this study was to determine the protective effect of p-coumaric acid (p-CA) against toluene-induced hepatotoxicity, nephrotoxicity and neurotoxicity in rats. Materials and methods. A total of 32 Sprague-Dawley male rats, 8 in each group, were used. 4 groups were formed as control, toluene, p-CA and toluene+p-CA. Animals in the control group, toluene group and p-CA group were given 0.9% NaCl, 0.9 mg/kg b.w toluene and 100 mg/kg b.w p-CA orally for 21 days, respectively. The animals in toluene+p-CA group were received p-CA for 3 days and from day 4, toluene and p-CA were applied together daily until day 25. On the 25th day, the study was terminated, blood and tissue samples were collected. Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and creatinine levels in serum, glutathione peroxidase (GSH-Px) activity and malondialdehyde (MDA) and glutathione (GSH) levels in the tissue samples were determined. Results. In this study, it was determined that there were significant increases in ALT and AST activities, and creatinine levels in toluene-induced group compared to control group. Moreover, there was a decrease in the GSH-Px activities and GSH levels, and an increase in the MDA levels compared to the control group. However, in the toluene+p-CA group, significant decreases in aminotransferases activities, creatinine and MDA levels, and significant increases in GSH-Px activities and GSH levels were determined compared to the toluene group. Conclusions. It has been determined that p-CA has a protective effect against toluene-induced hepatotoxicity, nephrotoxicity and neurotoxicity.
Chemical Studies of Rutherfordium (Element 104) : Part III. Solvent Extraction into Triisooctylamine from HF Solutions

The extraction of element 104, rutherfordium (Rf), and its group 4 homologs into 0.25 M triisooctylamine (TIOA) in o,m,p-xylene from various concentrations of hydrofluoric acid was studied. This extraction system was of particular interest because all group 4 cations studied formed complexes with the same coordination number (CN) of 6. Therefore, species extracted were similar and the extractability depends on the radii of the fluoride complexes. The studies showed that the extractability for the group 4 elements in this system decreases in the order Ti > Zr ~ Hf > Rf, in inverse order from the decrease in ionic radii Rf > Zr ~ Hf > Ti. This order is different than the order in the hydrolysis, TBP-HC1, and TBP-HBr extraction systems where Rf, due to decreasing CN, behaves more similarly to Ti than to Zr and Hf.
First-Principles Microkinetic Modeling of Methane Oxidation over Pd(100) and Pd(111)

The intrinsic activity of Pd(100) and Pd(111) for methane oxidation is investigated by Density Functional Theory (DFT)-based mean-field microkinetic modeling. The model includes 32 reaction steps, and the calculated turnover frequencies together with reaction orders compare favorably with experimental data. On both surfaces, the reaction proceeds via complete dehydrogenation of methane to elemental carbon followed by different mechanisms for carbon oxidization. Pd(100) is found to be more active than Pd(111) at temperatures from 400 to 1000 K. For both surfaces, the reaction order in methane approaches unity with increasing temperature. The reaction order in water is positive at low temperatures owing to water-promoted carbon oxidation. Methane dissociation is the main rate-controlling step for Pd(111), whereas formation of COH and CO is also controlling the rate over Pd(100). The present work uncovers the detailed reaction mechanisms for complete methane oxidation over palladium, which can be used in cat.
Parental mediation on children’s emotional behavioral adjustment in Kota Kinabalu, Sabah

Background: The present research was designed to investigate the influence of parental mediation on children’s emotional, behavioral adjustment and the moderation effect of children’s gender and parents’ education level on the association. Methods: 177 parents from Kota Kinabalu (central capital of Sabah) participated as the respondents answering online questionnaires which involved Livingstone and Helsper (2008) Parental Mediation (LHPM), and Strengths and Difficulties Questionnaire (SDQ). Results: Multiple regression analysis indicated a significant positive association of monitoring and active co-use with prosocial behaviors; F (2, 174) = 14.393, p < . 05. Monitoring was negatively significantly associated with conduct problems; F (1, 175) = 5.267, p < . 05 and hyperactivity/inattention; F (1, 175) = 13.920, p < . 05. Active co-use was negatively significantly associated with peer problems; F (1, 175) = 7.005, p < . 05. Interaction and technical restriction were not significantly associated with any contexts of SDQ. The moderation analysis for children’s gender and parents’ education level reflected no significant association. Conclusions: Overall, integrating monitoring and active co-use as parental mediation strategies is encouraged in Malaysia’s context. Both strategies significantly influence children’s adjustment in the emotional, behavioral context, promote positive behavior, and decrease the risk of negative ones.
EFFECT OF POMEGRANATE PEEL ON THE BLOOD LIPID PROFILE OF EXPERIMENTAL RATS

Background: This study was carried to investigate the effects of pomegranate peels(Punic granatumL), on the blood lipid level, some physiological parameters as liver function, kidney function, histological properties of Heart in hypercholestrmic. Rats were divided into 2 groups first group as negative group and the second group thypercholestrmic group which divided into 4 groups positive control, and 3 thypercholestrmic groups, fed on several diets containing 5%, 10%,15% of pomegranate peels for 28 days. Peel was cleaned from impurities and washed with tap water. Drying Oven air dry at 45 °C was used for 48 hours to dry the peel, then ground in a Multi Mill apparatus to passé through a 50 mesh sieve to obtain a fine peel powder . Bodyweight gain, feed intake and feed efficiency ratio were calculated at the end of experiment. Fasting blood sample were taken on day 28 for the determination of serum total cholesterol (TC) , serum triglycerides (TG) , HDL cholesterol,LDL cholesterol ,creatinine, serum urea, aspartate aminotransferase (AST) and glutamic pyruvic transaminase (GPT). The heart of all animals were carefully removed and slices from them were fixed in 85% alcohol for 24 hours, and then processed for paraffin embedding. Histological sections, 7 micron-thick, were cut and stained with heamatoxylin and eosin. They were then microscopically examined to evaluate the effects of the three differ concentration of formalin on these organs. It was concluded that treatment using pomegranate peel (Punic granatum L), reduced significantly LDL-c ,Serum triglycerides in hypercholestremic rats which fed different levels of pomegranate peel and the decrease was the best as the level of supplement peels increased.
Specifying and Testing Conversational User Interfaces

This thesis examines how to specify and test a Conversational User Interface (CUI) in an Agile environment. The research is conducted for and on behalf on Info Support, but its ﬁndings are generic and apply to all CUIs in general. CUIs are a new, trending technology with little to no research currently available and new frameworks are necessary for proper implementations of the system. During this research, the Conversation Design Framework (CDF) is created as the solution for specifying conversations of the CUI. The framework consists of seven concrete steps and aims to set a best practice design guideline for specifying an eﬀective and eﬃcient conversation. After elaborating the CDF, methods are proposed for testing the speciﬁcations that are created when using this model. A method of testing the personality is absent as only indirect testing suggestions are given, while many other testing can potentially be automated. Afterward, it is researched how well the well the Agile application of the CDF is and it is concluded that the framework can be implemented with high agility. The ﬁndings of this research provide a sound answer to the research question and are a good introduction to research into conversational user interfaces. Further research could be undertaken to create a model of testing chatbot personalities, validating the CDF by applying it to a real system through a case study and creating an evaluation method for bot frameworks.
FOREIGN OWNERSHIP, STOCK PERFORMANCE-RISK, AND MACROECONOMIC FACTORS IN ASEAN COUNTRIES

*Corresponding author. Management Program, BINUS Business School Undergraduate Program, Bina Nusantara University, Jakarta, Indonesia. Email: ahmad.maulin@binus.ac. id **Department of Management, Faculty of Economics and Business, Universitas Gadjah Mada, Yogyakarta, Indonesia. Email: mamduhmh@ugm.ac. id ***Department of Management, Faculty of Economics and Business, Universitas Gadjah Mada, Yogyakarta, Indonesia. Email: wayanfe@ugm.ac. id
A Lightweight Technique to Identify Equivalent Mutants

Mutation analysis is a popular but costly approach to assess the quality of test suites. Equivalent mutants are useless and contribute to increase costs. We propose a lightweight technique to identify equivalent mutants by proving equivalences with Z3 in the context of weak mutation testing. To evaluate our approach, we apply our technique for 40 mutation targets (mutations of an expression or statement) and automatically identify 13 equivalent mutations for seven mutation targets. We manually confirm that the equivalent mutants detected by our technique are indeed equivalent. Moreover, we evaluate our approach in the context of strong mutation testing against mutants generated by MuJava for 5 projects. Our technique detects all equivalent mutants detected by TCE. The results of our technique can be useful to improve mutation testing tools by avoiding the application of 13 mutations for 7 mutation targets.
Improving Dutch sentiment analysis in Pattern

In this paper we investigate methods for improving the sentiment analysis functionality of Pattern.nl, the Dutch submodule of Pattern, an open-source library for web mining and natural language processing. We discuss the impact on performance of three diﬀerent potential improvements: extending the module’s internal sentiment lexicon; removing subsets of neutral words from the sentiment lexicon; and improving the algorithm for combining multiple word-level sentiment ratings into a sentence-level sentiment rating. We evaluated the improvements on datasets from the product review domain (books, clothing and music) and a dataset of short emotional stories. The experiments show that lexicon expansion does not lead to better results; new normalization techniques, on the other hand, show a limited but consistent performance increase for sentiment ratings.
IMPACT OF ROOTING PROMOTER (PHOS ROOT-X) WITH OR WITHOUT USING IBA ON ROOTING OF TERMINAL AND MIDDLE CUTTINGS OF ROSEMARY (ROSMARINUS OFFICINALIS L.)

Corresponding author: F.F. Lasheen fawzy_lasheen@agr.asu. edu.eg ABSTRACT: This study was carried out in the Ornamental Plants Farm, Horticulture Department, Faculty of Agriculture, Ain Shams University, Cairo, Egypt. Two individual experiments were done. The first experiment aimed to study the effect of Phos root-x as newly rooting promoter at different rates (0, 0.5, 1, 1.5, 2, 2.5 and 3 cm3/l) on rooting of the terminal cuttings of rosemary plants. This study was carried out on 20th of July during the two seasons of 2019 and 2020. The experiment consisted of 7 treatments with 3 replicates, every replicate contained 3 cuttings per treatment. Data collected refer to that the 2.5 cm3/l of the newly rooting promotors were the best. Chemical analysis of terminal cutting refers to a decreasing in C/N ratio of terminal cuttings with increasing of Phos root-x concentrations. The second experiment was done on 25th of October in the same seasons, 2019 and 2020 for both terminal and middle cuttings and treated with Phos root-x complex with or without IBA, the treatments were 0, 1, 2, 3 cm3/l of Phos root-x with or without IBA at 0, 100, 500 ppm in combination. The experiment consisted of 24 treatments; each treatment consisted of three replicates with 3 cuttings per replicate. Data showed that for all parameters the best types for rooting was terminal cuttings, and a higher concentration of phos rootx favored better results especially with 3 cm3/l level. These results may be due to the higher concentrations of amino acids complex inside the newly rooting promotor compound (Phos root-x).
Analysing the spatio-temporal diffusion of economic change – advanced statistical approach and exemplary application

This article presents a spatio-temporal panel vector-autoregressive approach (SptpVAR) as an extended spatial econometric method for analysing spillover effects of regional economic change in time and space. The approach aims to extend the spatial dimension of SpVAR models by capturing the overall cross-regional spillover dynamics over time through additional estimations of effects into neighbouring regions and backward spillover to the source region. By showing how local economic dynamics trigger spillover dynamics in economically linked regions, the results are of particular interest to policy makers. To demonstrate the functioning of the SptpVAR approach, it is applied to 361 German regions using a regional growth model and a regional panel data set in the time-period 2000-2017 in an exemplary application.
Image Retrieval Based on Spatial Organization of Patches

This paper presents a novel approach for image retrieval by utilizing the spatial organization of image patches. Firstly, each image is presented as a set of patches and each patch is descripted as a bag-of-visual-words (BoW) feature. Secondly, the matrix of matching costs between all pairs of patches that come from the two images respectively is computed by utilizing both the appearance feature and spatial information. Finally, the distance between two images is obtained by minimize the total cost of matching using Hungarian algorithm. The resulting distance is applied to image retrieval. The experimental results indicate that the proposed method outperforms the traditional BoW method in image retrieval scenario.