Miracle-dz/UniFAR-FTUs huggingface dataset:
From Best Evidence to Best Practice: Enteral Nutrition from Continuous Nasal Feeding in Stroke Patients

Background Best evidence regarding enteral nutrition from continuous nasal feeding in stroke patients is limited. The aim of this study was to explore the best evidence of continuous nasal feeding in stroke patients and translate the evidence into clinical practice. Methods This study utilized the standard procedures of the Joanna Briggs Institute (JBI) evidence-based nursing centers’ clinical evidence-practice application system. The baseline assessment of stroke patients in the neurology ward was conducted. A pre- and post-implementation audit approach was used in this study and adopted the Getting Research into Practice program. We analyzed the compliance of nurses with best practice and its impact on patients’ gastrointestinal function and complications, aspiration, aspiration pneumonia, nurses’ daily workload of nasal feeding, and the length of hospitalization before and after implementing the evidence-based strategies. Results After application of the evidence-based strategies, nurses’ compliance with best practice was improved. The incidence of patients’ gastrointestinal complications including vomit (χ2 = 5.195, P=0.023), palirrhea (χ2 = 4.216, P=0.039), diarrhea (χ2 = 4.514, P=0.042), constipation (χ2 = 5.535, P=0.035) and gastric retention (χ2 = 4.541, P=0.042) decreased significantly after the application of the best evidence. The working time of nurses undergoing nasal feeding decreased from 23.71 ±3.22 min to 7.73 ±1.14 min (P =0.000) and the length of patient’s hospitalization decreased from 35.63 ±4.45 days to 35.00 ±3.70 days (P=0.534). The rate of aspiration, aspiration pneumonia did not show a significant difference after implementation of the evidence-based strategies. Conclusion The results revealed that the evidence-based practice of continuous nasal feeding in stroke patients is an effective method to improve nursing quality and reduce gastrointestinal complications, which was worthy of clinical application.
STUDIES ON THE POST THAW SEMEN QUALITY OF MARWARI HORSE AND POITOU DONKEY WITH ADDITION OF ALPHA-TOCOPHEROL, PENTOXIFYLLINE AND TAURINE IN SEMEN EXTENDER

The present study was conducted to evaluate post thawed semen qualities of Marwari horses and Poitou donkeys using different additives (α-tocopherol 1 mM, Pentoxifylline 3.5 mM and Taurine 25 mM) and their comparative assessment. In addition fresh and pre-freeze semen quality evaluation was also carried out. A total of 32 ejaculates from four Marwari horse and 32 ejaculates from four Poitou donkeys (8 ejaculates from each Marwari horse each Poitou donkey) stationed at NRCE, Bikaner between September-November 2016.The pre-freeze sperm motility, live sperm count, HOST, Acrosomal integrity and DNA integrity was evaluated in control and treatments. Semen was cryopreserved and after 24 hrs semen samples were thawed and the same parameters were evaluated. The appearance of the fresh semen of Marwari horse and Poitou donkey were watery milky white and creamy white respectively. Total semen volume, gel free semen volume and gel volume and fresh semen pH in Marwari horse and Poitou donkey were found to be 57.28±5.4 and 58.0±4.45 ml, 44.15±3.79 and 44.43±3.92 ml, 18±2.60 and 13.09±1.40 ml, 7.65±0.02 and 7.74±0.04, respectively. The sperm motility was significantly higher (P<0.01) in semen samples treated with antioxidants compared to untreated control both for Marwari horses and Poitou donkeys semen with the highest motility being observed in Pentoxifylline treatment. For other pre-freeze semen parameters (live sperm count, HOST, Acrosomal integrity and DNA integrity) similar effects were observed both for Marwari horses and Poitou donkeys semen. The beneficial effects of antioxidants additives in semen were also recorded in thawed semen after 24 hrs of cryopreservation. The post thaw sperm motility, live sperm count, HOST, Acrosomal integrity and DNA integrity were higher/significantly higher (P<0.01) in treatments compared to control. The effects of treatments were mostly better for Poitou donkeys compared to Marwari horse semen. It was concluded that various fresh semen parameters vary widely between Marwari stallions and Poitou donkeys. However the overall seminal parameters were similar between Marwari horses and Poitou donkeys except the sperm motility, sperm abnormalities, HOST, acrosome integrity and DNA integrity which were found to be significantly higher (P<0.01) in Poitou donkeys. Treatment of gel free semen of both species (Marwari horses and Poitou donkeys) with antioxidants improved the pre-freeze and post thaw seminal characteristics however, such improvements were significant for most parameters in Poitou donkeys only. Pentoxifylline was found to be the most suitable antioxidant additive for improving pre-freeze and post thaw semen quality in both Marwari horses as well as Poitou donkeys. मारवाड़ घोड़े एवं पोइटु गधे के वःता रत वीय मे अ फा े ं ु े े े े ं ु े े े े ं ु े े े Ðटोकोफेरोल ेे े , प टो! सीफाइलीन और टोर न के संयोजन का पघलने के प&ात वीय े ं े े े ं े े े ं े े क' गणुव)ा का अ*ययन ुु ु
Emergency care sick palliative and problems oncology in emergency department during the COVID-19 pandemic

Emergency medical care in palliative patients during the COVID-19 pandemic, it is important to provide a consistent treatment for stable patients that should be consistent with the goals and benefi ts, the perspective of these patients, but avoiding palliative patients with a poor prognosis that is unlikely to survive. Cancer is the second leading cause of death in the world around 8.8 million deaths a year. Worldwide, about 7-10 million patients are diagnosed with cancer each year, recently there has been a signifi cant increase in the number of cases diagnosed with cancer. About 70% of cancer deaths are in lowand middle-income countries. The goals of emergency medical care based on the criteria of BLS and ACLS, that is should be done “Do not do resuscitation, do not intubate but continue medical treatment excluding endotracheal intubation without prospects for the patient, but off ering BLS only treatment concentrated symptomatic. ED is often the only place that can provide the necessary medical interventions (e.g., intravenous fl uids or pain management medications. Medications as well as immediate access to advanced diagnostic tests when needed such as CT, RM and other diagnostic and treatment procedures. Research Article
Sequence Variation in GAL1 and GAL2 Genes in Khuzestan Local Chickens

Beta defensins were small, cationic peptides that bind to microbial membranes and disrupt their integrity, thereby exerting antimicrobial effects. These peptides play an important role in innate immunity against microbial pathogens. The aim of the present study was to detect sequence variations, if any, in some beta-defensin gene (GAL1 and GaL2) sequences in Khuzestan local chickens. Blood samples were collected from 20 local chickens and the genomic DNA was isolated using the standard phenol chloroform method. To detect sequence variation, the interested regions of GAL1 and GAL2 were amplified by specific primers with polymerase chain reaction (PCR). Then, the PCR products were sequenced in both directions. Analysis of the GAL1 gene found many sequence variations in the promoter region. GAL2 gene sequencing determined various sequence variations in intronic and exonic regions. These results suggest the existence of numerous genetic variations in these genomic sequences. Further association studies may help the development of a PCR-based genotyping test to select parents with a better immunity.
The Novel Coronavirus and Cellular Entry: A Therapeutic Conundrum?

Early this year, the novel coronavirus (SARS-CoV-2) pandemic sprang with incredible swiftness and caught the world unawares. As of this writing (little more than six months), at least 13 million people have been infected and over 570,000 have died [1] of the disease (COVID-19). The pathogenesis of the virus includes acute lung injury (ALI), heart failure and kidney disease [2]. While governments, pharmaceutical and biotech companies, research institutes, universities and hospitals pursue the urgent task of developing a vaccine, hopes of a positive outcome before the end of the year are being met with several challenges. Even with newer and more rapid approaches (e.g., nucleic acid vaccines), the development and clinical testing of a vaccine for safety and efficacy will take time. If initial clinical trials are successful, the manufacture, scaleup, storage/stability testing and distribution of the product must also be considered in the timeline. Meanwhile, effective therapies that could aid during this period are severely wanting. A dire need for effective therapy will be especially important if, barring ethical concerns, human challenge trials are expedited. Since my own previous experience has been in the area of drug discovery and not vaccine development, I would like to provide a perspective regarding a proposed therapy that could involve repurposed drugs and therefore, might be introduced in a timely manner. But first, a brief look at the therapeutic landscape for COVID-19 at present. Please note that due to the urgency of the pandemic, many of the recent references are publications that have not been peer reviewed.
Synthesis and antibiofilm activity of metal oxide nanoparticles against some Gramnegative bacteria

The evolution of the green and ecological biosynthetic methods of the Nanoparticles works as a vital part of the field of Nanobiotechnology in the future. The ecofriendly fast biosynthesis of titanium Nanoparticles utilizer Lactobacillus acidophilus isolated from dairy products. The synthesized nanoparticles were characterized using Atomic Force Microscopy (AFM). The morphological characteristics were found to oval and spherical in shape with the average size (71) nm synthesized in MRS broth. The formation to control biofilms by potential nanoparticles, as a job of the biocidal, delivery capabilities and anti-adhesive, is yet under close scrutiny. Titanium nanoparticles synthesis biologically function a possible role in higher important antimicrobial effectiveness against Gram-negative pathogens E. coli, Shigella, Klebsiella, Proteus, and Pseudomonas. Its biofilm formation were found to have significant effects after isolates were treated with sub MIC titanium nanoparticle both and cultured on the specific media. Results appear the TiO2-NP had antiadhesive and antibiofilm effect versus gram-negative causal bacteria especially Proteus spp. , Klebsiella spp. and Pseudomonas spp. In both Congo red and tube methods respectively. TI nanoparticles with concentration appropriate 16 mg. /ml could significantly reduce in biofilm formation for all isolates under study except E. coli.
The prevalence and genetic diversity of feline immunodeficiency virus and feline leukemia virus among stray cats in Harbin, China

Feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) are typical retroviruses that are transmitted horizontally among felines. FIV results in symptoms of immunodeficiency such as weight loss, chronic lesions, opportunistic infections, and neurological abnormalities, while FeLV is known to cause a variety of neoplastic and nonneoplastic diseases in cats, such as thymic lymphoma, multicentric lymphoma myelodysplastic syndromes, acute myeloid leukemia, aplastic anemia, and immunodeficiency. The prevalence and genetic diversity of FIV and FeLV in stray cats have not been investigated. In this study, polymerase chain reaction and enzyme-linked immunosorbent assay were used to test 198 blood samples from stray cats from Harbin, China, for FIV infection, FeLV seropositivity, and the prevalent subtypes of FIV. The gag capsid amino terminus and env V3-V5 regions of FIV samples were used to perform phylogenetic analysis. In total, 3% (6/198) of the stray cats from five districts of Harbin was PCR- were ELISA-positive for FIV. The FeLV positivity rate was 1% (2/198). Phylogenetic analysis of the gag and env sequences showed that cats were infected with FIV subtype A. This is the first study examining the prevalence rates of FIV and FeLV and the prevalent subtypes of FIV of stray cats in Harbin. These studies will enrich the epidemiological understanding of FIV and FeLV.
Histological and Immunohistochemical Study on the Effect of Constant Light Exposure on T Lymphocyte Subsets in the Thymus and Lymph Node of Male Albino Rats

Background: Today there is a widespread exposure to high levels of light at night. This causes divergence from the natural environment and leads to significant implications on the circadian rhythm. Constant light exposure inhibits melatonin secretion and increases serum concentration of corticosterone. The immune system is very sensitive to stress.Aim of the Work: to study the effect of chronic exposure to constant light (as a model of stress) on the T lymphocytes populations and distribution in the thymus and lymph node.Material and Methods: animals were divided into two groups (10 rats each). The 1st group considered as control group, was kept on a day light-darkness for 12-12 h. The 2nd group was kept under complete artificial light for a period of 4 weeks. Thymus glands and the cervical lymph nodes of rats were removed and processed for haematoxylin and eosin, and immunohistochemical staining for CD3, CD4 and CD8.Results: lymphocytic depletion was noticed in the thymus and lymph nodes of the constant light exposed group. Also the distribution of CD3 and CD4 positive cells were altered in the lymph node of the same group.Conclusion: Constant light stress causes lymphocytic depletion and alters lymphoid cell subsets distribution both in the thymus and lymph nodes.
POLICY OF SPECIAL ECONOMIC ZONES AND ENVIRONMENTAL POLICIES IN BANGKA BELITUNG: A STAKEHOLDER ANALYSIS

Purpose of the Study: The purpose of this article was to categorize and identify the role of stakeholders in the development of SEZs policy. Furthermore, the researchers set limits on the development of SEZs policy in Tanjung Gunung and Sungailiat. Methodology: This article used qualitative research with approach Participatory Action Research (PAR). The data were obtained through in-depth interviews, observation, and a literature study about the focus of research. The researchers also conducted focus group discussions with related agencies or institutions within the Bangka Belitung Province Government, Bangka Regency, and Central Bangka Regency. Main Findings: The results indicate that many stakeholders are involved in the SEZs policy from within both the central government and local governments. In addition, there are additional key stakeholders namely central government as represented by National Council . The primary stakeholders are local governments, and the secondary stakeholders are the mining entrepreneurs and the wider community. Application of this study: The importance of stakeholder analysis is to resolve any that arise in the development of SEZ policies in Bangka Belitung. Moreover, stakeholder analysis can help to limit the issues that can be solved in ways that are technically applicable and politically appropriate by prioritizing the common interests and greater good. Novelty/Originality: No specific research discussing the SEZ policy in Bangka Belitung, especially stakeholder analysis, has been conducted before. Stakeholder analysis identifies policy actors to realize the development of SEZs policy in Bangka Belitung which environmental friendly.
Antioxidant and Antimicrobial Screening of Endophytic Fungi Culture Filtrate from Purwoceng (Pimpinella alpina Molk) Leaf

This is a preliminary study to determine the bioactivity potential of purwoceng leaf endophytic fungal metabolites. Endophytic fungi were isolated from purwoceng leaf and their secondary metabolite from culture filtrate were subjected to identify the antimicrobial, antioxidant, and phytochemical screening. The antioxidant activity was screened by scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH). The antimicrobial activity was screened using a good agar method toward Salmonella typhi, Escherichia coli, Bacillus subtilis, Staphylococcus aureus, dan Candida albicans. This study obtained five distinctive endophytic fungi isolates named A, B, C, D, and E. The endophytic fungal culture filtrate of C has the most extensive antimicrobial activity with phytochemical screening showing alkaloids, saponins, and terpenoids. The antioxidant potential of all culture filtrates seemed low because the DPPH amount was interfered with by pigment compounds. Culture filtrate of fungi A showed the highest antioxidant activity and contained phenolic and alkaloid compounds.
Bayesian inference in based-kernel regression: comparison of count data of condition factor of fish in pond systems

ABSTRACT The discrete kernel-based regression approach generally provides pointwise estimates of count data that do not account for uncertainty about both parameters and resulting estimates. This work aims to provide probabilistic kernel estimates of count regression function by using Bayesian approach and then allows for a readily quantification of uncertainty. Bayesian approach enables to incorporate prior knowledge of parameters used in discrete kernel-based regression. An application was proposed on count data of condition factor of fish (K) provided from an experimental project that analyzed various pond management strategies. The probabilistic distribution of estimates were contrasted by discrete kernels, as a support to theoretical results on the performance of kernels. More practically, Bayesian credibility intervals of K-estimates were evaluated to compare pond management strategies. Thus, similarities were found between performances of semi-intensive and coupled fishponds, with formulated feed, in comparison with extensive fishponds, without formulated feed. In particular, the fish development was less predictable in extensive fishpond, dependent on natural resources, than in the two other fishponds, supplied in formulated feed.
SHORT COMMUNICATION FIELD PERFORMANCE OF ALNUS CORDATA LOISEL (ITALIAN ALDER) INOCULATED WITH FRANKhi AND VA-MYCORRHIZAL STRAINS IN MINE-SPOIL AFFORESTATION PLOTS

ERICA LUMINI,‘* MARCO BOSCO,‘~ GIGLIOLA PUPPI,~ RAFFAELLA 1~0~1,~ MAURO FRA~GIANI,~ ENRICO BURESTI~ and FRANCO FAVILLI’ ’ Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche. , Universiki degli Studi di Firenze, Piazzale delle Cascine 27, 50144 Florence, 2Dipartimento di Biologia Vegetale, Universita ‘La Sapienza’, Largo Cristina di Svezia 24, 00165 Rome and ‘Istituto Sperimentale per la Selvicoltura, Viale S. Margherita 80, 52100 Arezzo, Italy
Effect of grain type and dried distillers grains plus solubles oil concentration on site of digestion in cattle fed finishing diets

Abstract: The objective of this experiment was to determine the effects of grain type (rolled corn vs. rolled barley) and oil concentration of dried corn distillers grains plus solubles (DDGS; moderate = 7.9% vs. low = 4.5% ether extract) on site of digestion. Seven ruminally and duodenally cannulated Holstein steers (716 ± 8.9 kg) were used in a 4 × 7 Youden square with experimental periods of 24 d. True ruminal organic matter (OM) and crude protein (CP) digestibility (% of intake) as well as intestinal (% of entering duodenum) and total tract starch digestibility was greater (P ≤ 0.03) in steers fed diets containing barley than in steers fed diets containing corn. Ruminal disappearance and ruminal, intestinal, and total tract OM, CP, and starch digestibility were not influenced (P ≥ 0.11) by feeding diets containing DDGS with differing oil concentration. Total tract lipid digestibility (%) was greater (P < 0.001) in steers fed diets containing moderate-oil DDGS than low-oil DDGS. These data indicate that including a low-oil DDGS, as compared with a moderate-oil DDGS, in finishing diets containing rolled corn or rolled barley does not influence intake or site of digestion of nonlipid components.
Using Continuous‐Time Spatial Capture–Recapture models to make inference about animal activity patterns

Abstract Quantifying the distribution of daily activity is an important component of behavioral ecology. Historically, it has been difficult to obtain data on activity patterns, especially for elusive species. However, the development of affordable camera traps and their widespread usage has led to an explosion of available data from which activity patterns can be estimated. Continuous‐time spatial capture–recapture (CT SCR) models drop the occasion structure seen in traditional spatial and nonspatial capture–recapture (CR) models and use the actual times of capture. In addition to estimating density, CT SCR models estimate expected encounters through time. Cyclic splines can be used to allow flexible shapes for modeling cyclic activity patterns, and the fact that SCR models also incorporate distance means that space–time interactions can be explored. This method is applied to a jaguar dataset. Jaguars in Belize are most active and range furthest in the evening and early morning and when they are located closer to the network of trails. There is some evidence that females have a less variable pattern than males. The comparison between sexes demonstrates how CT SCR can be used to explore hypotheses about animal behavior within a formal modeling framework. SCR models were developed primarily to estimate and model density, but the models can be used to explore processes that interact across space and time, especially when using the CT SCR framework that models the temporal dimension at a finer resolution.
Air Pollution Concentration Forecast Method Based on the Deep Ensemble Neural Network

The global environment has become more polluted due to the rapid development of industrial technology. However, the existing machine learning prediction methods of air quality fail to analyze the reasons for the change of air pollution concentration because most of the prediction methods take more focus on the model selection. Since the framework of recent deep learning is very flexible, the model may be deep and complex in order to fit the dataset. Therefore, overfitting problems may exist in a single deep neural network model when the number of weights in the deep neural network model is large. Besides, the learning rate of stochastic gradient descent (SGD) treats all parameters equally, resulting in local optimal solution. In this paper, the Pearson correlation coefficient is used to analyze the inherent correlation of PM2.5 and other auxiliary data such as meteorological data, season data, and time stamp data which are applied to cluster for enhancing the performance. Extracted features are helpful to build a deep ensemble network (EN) model which combines the recurrent neural network (RNN), long short-term memory (LSTM) network, and gated recurrent unit (GRU) network to predict the PM2.5 concentration of the next hour. The weights of the submodel change with the accuracy of them in the validation set, so the ensemble has generalization ability. The adaptive moment estimation (Adam) an algorithm for stochastic optimization is used to optimize the weights instead of SGD. In order to compare the overall performance of different algorithms, the mean absolute error (MAE) and mean absolute percentage error (MAPE) are used as accuracy metrics in the experiments of this study. The experiment results show that the proposed method achieves an accuracy rate (i.e., and %) and outperforms the comparative models.