Miracle-dz/UniFAR-FTUs huggingface dataset:
Quantitative Analysis of Surface Contouring with Pulsed Bipolar Radiofrequency on Thin Chondromalacic Cartilage

The purpose of this study was to evaluate the quality of surface contouring of chondromalacic cartilage by bipolar radio frequency energy using different treatment patterns in an animal model, as well as examining the impact of the treatment onto chondrocyte viability by two different methods. Our experiments were conducted on 36 fresh osteochondral sections from the tibia plateau of slaughtered 6-month-old pigs, where the thickness of the cartilage is similar to that of human wrist cartilage. An area of 1 cm2 was first treated with emery paper to simulate the chondromalacic cartilage. Then, the treatment with RFE followed in 6 different patterns. The osteochondral sections were assessed for cellular viability (live/dead assay, caspase (cell apoptosis marker) staining, and quantitative analysed images obtained by fluorescent microscopy). For a quantitative characterization of none or treated cartilage surfaces, various roughness parameters were measured using confocal laser scanning microscopy (Olympus LEXT OLS 4000 3D). To describe the roughness, the Root-Mean-Square parameter (Sq) was calculated. A smoothing effect of the cartilage surface was detectable upon each pattern of RFE treatment. The Sq for native cartilage was Sq = 3.8 ± 1.1 μm. The best smoothing pattern was seen for two RFE passes and a 2-second pulsed mode (B2p2) with an Sq = 27.3 ± 4.9 μm. However, with increased smoothing, an augmentation in chondrocyte death up to 95% was detected. Using bipolar RFE treatment in arthroscopy for small joints like the wrist or MCP joints should be used with caution. In the case of chondroplasty, there is a high chance to destroy the joint cartilage.
A Cost-Benefit Analysis of Indexing Big Data with Map-Reduce

— We reflect upon the challenge a Big Data analyst faces when dealing with the complex problem of considering the approximate amount of nodes needed for a computation to be completed within a given time. We develop a formula which allows anyone, with the job of designing clusters for massive data sets, to do so. We consider the problem of Inverted Index construction which is widely used in Information Retrieval. We present the various aspects and the challenges of this problem along with details on how the system we developed works.
AN EFFECTIVE APPROACH USING THE PRINCIPLE OF FUSION TO DEHAZE THE UNDERWATER IMAGE

: The underwater images are usually degraded due to the medium scattering and absorption. An effective technique based on multiscale fusion to enhance and dehaze such images has been introduced in the paper. The two images derived from white-balancing and color compensating of the original image are processed for the fusion. The associated weight maps of derived images are defined for transition of color contrast and edges to the output image. The multiscale fusion technique removes the artifacts in the low frequency components of the reconstructed image due to sharp weight map transitions. PCQI and UCIQE are used to evaluate the quality of the underwater image which proves that the proposed algorithm improves the accuracy of various image processing applications. The evaluated results also reveal that the algorithm is reasonably independent of the camera settings .
Generalized Periodontitis in a Patient with Established Crohn’s Disease: A Rare Case Report

Introduction Periodontal health and disease are dependent on a complex interplay of biofilm-host tissue and immuno-regulation [1]. An association between periodontitis and various other systemic inflammatory conditions is well-established [2]. Such systemic conditions might, also, influence the clinical outcome in case of implant therapy in periodontitis patients as they might affect the soft tissues, the general trabecular bone pattern as well as affect the successful outcomes of osseo-integration [3-5]. Inflammatory Bowel Disease (IBD) has two components, namely Crohn's disease and Ulcerative colitis. Crohn’s disease is a chronic granulomatous disease process characterized by persistent intestinal inflammation, ulceration, formation of granulomatous lesions and a generalized trans-mural inflammation throughout the intestines [6]. The common oral manifestations of Crohn's disease were first described in 1969 which included gingival hyperplasia, fascicular eruptions, generalized periodontitis and ulcerations [7]. Flemmig et al. [8] concluded from the findings of their study that patients with Inflammatory Bowel Disease (IBD) had an 11% higher prevalence rate of periodontitis. Vavricka et al. [9] concluded from their study that markers specific to periodontitis were found in higher percentage in patients affected with chronic Inflammatory Bowel Disease (IBD).
Monitoring and Understanding Enterprise Collaboration Platform Outcomes and Benefits Change

Enterprise collaboration platforms integrating traditional collaboration tools and enterprise social software are shaped and designed through use. To date, existing research has not studied in any depth how their outcomes and benefits change over time. In this paper, we develop the MoBeC framework for capturing and monitoring how outcomes and benefits of enterprise collaboration platforms are changing over time. The framework is applied in an empirical setting adopting a longitudinal case study design. The study findings contribute to the deeper understanding of the dynamic and evolving nature of such platforms.
Biological weathering on the first gallery wall of Angkor Wat temple , Cambodia *

Tsunami disaster after the Tohoku Earthquake that occurred in 2011 increased our concern tsunami in the Japan Sea side of the coastal region as well as the Pacific side. We can find the description of large scale tsunami disaster occurred in the Sea of Japan side in historical documents. In this study, we investigated the tsunami disaster along the Japan side coast using the sediment core from the lake kitagata, Fukui prefecter. Lake Kitagata is a brackish lake connected to the Sea of Japan.One of the tsunami records occurred in this region is the Tensho tsunami in 1586. This tsunami was described in two Literatures, mentioning that the huge waves overwashed the land. However ,no sedimentological traces of this tsunami has been reported.Possible tsunami sediment layer was found from the depth 170-203cm of the core (KT14-5), which is collected from the point about 2 km island from the sea. The layer shows coarse mineral particle size, increase in the amount of calcium carbonate, decrease in the amount of organic matter and moisture content. A corresponding layer in another core include the shell of sea origin.In addition, diatom assamblage show ,that marine and brackish species were about 70% of the total diatom,while that of a sample 30 cm beneath this layer exhibit freshwater species with about 60 percent of the total diatom species. These lines of observation indicate that this layer is tsunami deposit. C dating results in 1404-1474 cal AD for a shell from this layer (196cm) slightly older than, but more or less equivalent to the age of Tensho tsunami. This finding is one of the evidences for a large scale tsunami disaster in the past in Hokuriku region.
Epigenetic regulation of the MEG3-DLK1 microRNA cluster in human Type 2 diabetic islets

Vasumathi Kameswaran1,3, Nuria C. Bramswig1,3, Lindsay B. McKenna1,3, Melinda Penn1,3, Jonathan Schug1,3, Nicholas J. Hand4, Ying Chen5, Inchan Choi1,3, Anastassios Vourekas6, Kyoung-Jae Won1,3, Chengyang Liu2, Kumar Vivek2,7, Ali Naji2,3, Joshua R. Friedman4, and Klaus H. Kaestner1,3 1Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA 2Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA 3Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA 4Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA 5Genomics and Computational Biology Graduate Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA 6Department of Pathology and Laboratory Medicine, Division of Neuropathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
The effect of ApoE ε 4 on clinical and structural MRI markers in prodromal Alzheimer's disease.

Background Apolipoprotein E (ApoE) ε 4 has been identified as the strongest genetic risk factor for Alzheimer's disease (AD). However, the importance of ApoE ε 4 on clinical and biological heterogeneity of AD is still to be determined, particularly at the prodromal stage. Here, we evaluate the association of ApoE ε 4 with clinical cognition and neuroimaging regions in mild cognitive impairment (MCI) participants based on the AT (N) system, which is increasingly essential for developing a precise assessment of AD. Methods We stratified 178 A+T+MCI participants (prodromal AD) into ApoE ε 4 (+) and ApoE ε 4 (-) according to ApoE genotype from the Alzheimer's Disease Neuroimaging Initiative (ADNI). We determined Aβ-positivity (A+) by the standardized uptake values ratios (SUVR) means of florbetapir-PET-AV45 (the cut-off value of 1.1) and fibrillar tau-positivity (T+) by cerebrospinal fluid (CSF) phosphorylated-tau at threonine 181 position (p-Tau) (cut-off value of 23 pg/mL). We evaluated the effect of ApoE ε 4 status on cognitive conditions and brain atrophy from structural magnetic resonance imaging (MRI) scans. A multivariate analysis of variance was used to compare the differences of cognitive scores and brain atrophy from structural MRI regions of interest (ROIs) between both groups. Furthermore, we performed a linear regression model to assess the correlation between signature ROIs of structural MRI and cognitive scores in the prodromal AD participants. Results ApoE ε 4 (+) prodromal AD participants had lower levels of CSF Aβ 1-42, higher levels of t-Tau, more memory and global cognitive impairment, and faster decline of global cognition, compared to ApoE ε 4 (-) prodromal AD. ApoE ε 4 (+) prodromal AD participants had a thinner cortical thickness of bilateral entorhinal, smaller subcortical volume of the left amygdala, bilateral hippocampus, and left ventral diencephalon (DC) relative to ApoE ε 4 (-) prodromal AD. Furthermore, the cortical thickness average of bilateral entorhinal was highly correlated with memory and global cognition. Conclusions ApoE ε 4 status in prodromal AD participants has an important effect on clinical cognitive domains. After ascertaining the ApoE ε 4 status, specific MRI regions can be correlated to the cognitive domain and will be helpful for precise assessment in prodromal AD.
Study of Parameters for Improving Performance and Competitiveness of Construction Companies in Indonesia

his research is a continuation of research and development from previous years research. The purpose of this study is to analyze and prove the relationship between parameters to improve the performance and competitiveness of construction companies in Indonesia. The location of research data collection was conducted purposively in six provinces in Indonesia, namely : DKI Jakarta, West Java, Central Java, Bali and West Sumatra. The research sample of 386 small, medium and large qualification construction companies whose numbers are determined proportionally. While the research respondents were company owners, directors and company managers. Data collection tools use nominal scale questionnaires (Likert 1-5). Statistical data analysis using SPSS and Smart PLS software. The results of the study concluded that the project management process group parameters and project management knowledge area according to PMBOK5th had a positive and significant effect on improving the performance and competitiveness of Indonesian construction companies. There are differences in the importance of group process implementation priorities for small, medium and large qualification construction companies. Key words: process group, management, performance, competitiveness, construction
An insight into hair follicle via epigenetic modification and molecular docking: A review

Hair follicle, a mini-organ developed in the epithelial layer is one of the complex structural and functional unit of the hair growth. In this review, we discuss about the Androgenetic alopecia, where miniature of the hair takes place converting testosterone to dihydrotestosterone by 5-alpha reductase. We also discuss about LHX2, which is responsible for the initiation of anagen phase of hair growth. Prostaglandin D2 synthase converts PGH2 to PGD2, which leads to the hair loss. Few key players in the epigenetic modification process like DNMT1, DNMT3a, DNMT3b, DNMT3L and TETs group of proteins, which gives structural stability to the gene and expression, play an important role in hair growth. We review the previous and future possibilities of drug design for preventing hair loss with the help of molecular docking performed on these players as well as on Prostaglandin D2 synthase.
Determination of phase space region for cross-check validation of the neutron detection in the BINA experiments

Deuteron breakup reactions are basic laboratories for testing nuclear force models. Recent improvements in the data analysis allow for direct identification of neutrons in the BINA detection setup. This opens up the opportunity to study new aspects of few-nucleon system dynamics like charge dependence of nuclear force or Coulomb interaction. In this paper we determine regions along the kinematical curves where differential cross section of deuteron-proton breakup reactions can be measured by the proton-neutron and proton-proton coincidences simultaneously. %In this paper we determine regions along the kinematical curves where differential cross section of $^1$H$(d,pp)n$ and $^1$H$(d,pn)p$ breakup reactions overlap. This is particularly useful for validation of the neutron detection technique.
Risk Assessment of Oxygen Lance Burning Loss Using Bow-Tie Analysis Based on Fuzzy Theory

Oxygen lances (OLs) are important devices used in converter steel making. However, the occurrence of OL burning loss (OLBL) failure may lead to explosion accidents. To better prevent OLBL failure, it is necessary to perform a probabilistic assessment. Bow-tie analysis based on fuzzy theory was proposed to assess OLBL, which represents a hazardous event. In this paper, fuzzy theory based on triangular fuzzy numbers (TFNs) was applied to calculate the failure data. Fuzzy fault tree analysis (FFTA) in combination with the improved similarity aggregation method (ISAM) was employed to reduce the error generated due to the subjective judgement of experts. Furthermore, a comprehensive importance analysis method was developed to rank the importance of basic events (BEs), facilitating the adoption of the corresponding safety decisions. When performing fuzzy event tree analysis (FETA), the occurrence probability of outcome events (OEs) was determined by conducting a layer of protection analysis (LOPA). Finally, safety measures were proposed based on the assessment results to achieve safe production. The results indicated that the use of bow-tie analysis is appropriate to perform qualitative and quantitative assessment. Through bow-tie analysis based on fuzzy theory, the occurrence probability of OLBL was determined to be in the interval (5.34E − 02, 2.69E − 01). By adding independent protective layers (IPLs), the occurrence probability of OEs caused by OLBL can be effectively reduced.
OVERSUPPLY CAUSES OF DOUBLE STOREY TERRACE HOUSES IN JOHOR BAHRU

Malaysia is currently facing an increasing problem in housing oversupply with Johor holding the second largest share in the nation’s oversupply stocks. Thus, this paper investigates the factors affecting housing oversupply in Johor, focusing on double terrace houses in Johor Bahru. The first objective reviews the causes of housing oversupply. The second objective evaluates the level of influence of factors on double storey terrace house oversupply in Johor Bahru. Questionnaires are distributed to 21 real estate agents in Johor Bahru to obtain their views on the housing oversupply factors. The level of influence of housing oversupply factors are ranked based on mean score. The study observes that housing unaffordability caused by expensive house prices and tight lending conditions strongly influence the housing oversupply in Johor Bahru. Thus, all parties in the property sector must work together to improve the buyers’ housing affordability to reduce housing oversupply in Johor Bahru. The findings of the study guides the developers, planners, policy makers and financial institutions in making property planning and financing decisions. Future research may attempt to investigate factors influencing the oversupply of other housing types or extend the study area to allow further understanding on housing oversupply problems in Malaysia.
Correcting Distorted Objects Formed in a Concave Mirror

Concave mirrors are capable of gathering light rays and optically forming objects in midair so we may reach them by hand. In this study, we propose a concave mirror-based display technique that features large viewing angles. Generally, optical systems of concave mirrors cause formed objects to be distorted when allowing large viewing angles. We aim to correct the distortion of the formed objects by pre-warping the original ones, so that the observer sees them not-distorted. Finally we conﬁrm our approach by both computer simulation and a simple experiment.
A Go-to-FPGA Compilation Framework for Streaming Applications

In this report, we show the potential advantage of Go programming language that leverages communicating sequential processes (CSP) in FPGA accelerator development. We build a compilation framework to compile a Go program to an FPGA accelerator. The compiler covers two optimizations, ﬁne-grained parallelism and take-level pipeline, that we identiﬁed based on the CSP to improve the throughput of generated accelerator designs. Finally, we analyze in this report that several applications could beneﬁt from the proposed framework.
The Clastering in Analyzing Effect of the Presence of Patient Age, Infection and Systemic Disease of Connective Tissue on the Occurrence of Dehiscence Laparotomy

Introduction Dehiscence of laparotomy is a sudden partial or complete opening or tearing wounds, or the formation of cracks in the surgical wound sewinged [1]. Complete wound disruption with evisceration of abdominal organs requires urgent reintervention. It occurs most often during the first week after surgery. It occurs in 0.5% to 3% of operated patients [2]. Dehiscence of laparotomy is accompanied by high morbidity and mortality that ranges up to 40%.
The influence of the complex training method on maximal isometric force production of junior basketball players

During the period of ten weeks, a study has been conducted on the effects of a complex training method on the maximal isometric muscle force, its peaking time, and the rate of force development in the semi-squat test. The participants of the study were twenty junior basketball players (average age 16.4+/-0.7; mean body height 186.2cm+/-9.2; mean body weight 75,4+/-7.5kg; mean body fat percentage 12,83%+/-1.15). The participants were divided into experimental (n=10) and control group (n=10). The experimental group, besides technical-tactical training sessions, had additional complex training, while the control group had technical-tactical training sessions only. At the final testing, the results of maximal isometric muscle force and the explosive power index, have significantly improved in the experimental group, while the control group did not make significant progress. There were no significant changes in the maximal isometric muscle force's peak time at the final testing. The study findings indicate that application of the complex training method has positive effects on the development of maximal isometric force, and the rate of force development.
A Sphere Decoding Algorithm for MIMO Receivers

: : Modern wireless communication system demanding high data rate operating in bandwidth deficient world is using Multiple Input Multiple Output (MIMO) antenna arrangement. MIMO transmission has become a popular technique to increase spectral efficiency. MIMO supports greater data rate and higher reliability in wireless communication. The receivers employing linear receivers or decision feedback detectors in detection use less hardware are of suboptimal. Optimal detectors are realized by Maximum Likelihood detector can achieve superb performance, yet the computational complexity is enormously high. Therefore suboptimal detectors such as Viterbi Decoding, Sphere Decoding, Genetic Algorithm based Decoder are reach the performance of ML detectors
Field-directed and Template-assisted Magnetic Nanoparticle Self-assembly

A method is presented for controlling the self-assembly of magnetically functional nanoparticles into extended spatial patterns with nanoscale feature resolution. Softmagnetic template elements embedded in a nonmagnetic substrate are used to guide the assembly. The templates are magnetized using a bias field to produce localized regions of attractive and repulsive magnetic force that enable nanoscale precision of particle placement. The method is demonstrated using a computational model that simulates the assembly process taking into account magnetic and hydrodynamic forces including interparticle interactions, Brownian diffusion, Van der Waals force and effects of surfactants. The analysis shows that complex patterns of particles can be assembled within milliseconds by controlling the particle volume fraction and the core-shell dimensions. The method broadly applies to arbitrary geometries and multi-layer particles having at least one magnetic component. It opens up opportunities for the scalable fabrication of nanostructured materials for a broad range of applications.
Students' Perceptions and Challenges in Improving Speaking Ability in Public and Private University

Speaking is one of skills that difficult to master by students in Indonesia, little research has been done to investigate students’ perceptions and challenges in improving speaking ability: the analysis study between English Education Department students. Using a qualitative descriptive approach, this research selected learners’ studying in private and public university as research respondents. The findings suggest that the main causes of speaking difficulties were affected by shyness, lack of vocabularies, and environment of learning; dealing with mistake and lecturers’ reaction during English speaking performance. This study is beneficial to improve EFL learners to improve their speaking ability. It is important to lecturers identifying their students’ speaking skill as a matter of applying a more effective learning strategy. Keywords— English students’ perceptions and challenges, and speaking ability
Cosmoligical N -body code GLAM.

Here we provide description of the GLAM code: a parallel version of the Particle-Mesh cosmological code, that provides us with a tool to quickly generate a large number of N -body cosmological simulations with a reasonable speed and acceptable resolution. We call our code Parallel Particle-Mesh GLAM (PPM-GLAM), which is the core of the GLAM (GaLAxy Mocks) pipeline for massive production of galaxy catalogs. PPM-GLAM generates the density ﬁeld, including peculiar velocities, for a particular cosmological model and initial conditions.