Miracle-dz/UniFAR-FTUs huggingface dataset:
Automatic Prediction of Recurrence of Major Cardiovascular Events: A Text Mining Study Using Chest X-Ray Reports

Methods We used EHR data of patients included in the Second Manifestations of ARTerial disease (SMART) study. We propose a deep learning-based multimodal architecture for our text mining pipeline that integrates neural text representation with preprocessed clinical predictors for the prediction of recurrence of major cardiovascular events in cardiovascular patients. Text preprocessing, including cleaning and stemming, was first applied to filter out the unwanted texts from X-ray radiology reports. Thereafter, text representation methods were used to numerically represent unstructured radiology reports with vectors. Subsequently, these text representation methods were added to prediction models to assess their clinical relevance. In this step, we applied logistic regression, support vector machine (SVM), multilayer perceptron neural network, convolutional neural network, long short-term memory (LSTM), and bidirectional LSTM deep neural network (BiLSTM). Results We performed various experiments to evaluate the added value of the text in the prediction of major cardiovascular events. The two main scenarios were the integration of radiology reports (1) with classical clinical predictors and (2) with only age and sex in the case of unavailable clinical predictors. In total, data of 5603 patients were used with 5-fold cross-validation to train the models. In the first scenario, the multimodal BiLSTM (MI-BiLSTM) model achieved an area under the curve (AUC) of 84.7%, misclassification rate of 14.3%, and F1 score of 83.8%. In this scenario, the SVM model, trained on clinical variables and bag-of-words representation, achieved the lowest misclassification rate of 12.2%. In the case of unavailable clinical predictors, the MI-BiLSTM model trained on radiology reports and demographic (age and sex) variables reached an AUC, F1 score, and misclassification rate of 74.5%, 70.8%, and 20.4%, respectively. Conclusions Using the case study of routine care chest X-ray radiology reports, we demonstrated the clinical relevance of integrating text features and classical predictors in our text mining pipeline for cardiovascular risk prediction. The MI-BiLSTM model with word embedding representation appeared to have a desirable performance when trained on text data integrated with the clinical variables from the SMART study. Our results mined from chest X-ray reports showed that models using text data in addition to laboratory values outperform those using only known clinical predictors.
Total Knee Arthroplasty Improved Locomotive Syndrome in Knee Osteoarthritis Patients: A Prospective Cohort Study Focused on Total Clinical Decision Limits Stage 3

Purpose The purpose of this study is to investigate the treatment efficacy of total knee arthroplasty (TKA) on locomotive syndrome (LS) focusing on total clinical decision limit (CDL) stage 3 leading to revealing the motor function indicators that can predict LS improvement in knee osteoarthritis patients who had received TKA. Methods This prospective cohort study was conducted in 47 patients evaluated as total CDL stage 3 before TKA who received primary TKA on the operated side and were diagnosed with Kellgren-Lawrence grade 2, 3, or 4 knee osteoarthritis on the nonoperated side. LS was evaluated using stand-up test, two-step test, and 25-Question Geriatric Locomotive Function Scale. In addition, the motor function indicators which could predict the LS improvement were examined. All assessments were conducted before TKA and three months after TKA. Results Of the 47 subjects who were evaluated to be in total CDL stage 3 before TKA, 13 patients (27.7%) were determined to show improvements in total CDL. From the result of the decision tree analysis, when the CDL of the two-step test before TKA was 1 or less, the improvement rate was 83.3%. Even if the CDL of the two-step test before TKA was higher than 1 and if the 3 m-Timed Up and Go test (3m-TUG) before TKA was 9.6 or less, the improvement rate was 50%. Conclusions As of three months after surgery, TKA can improve LS in about 30% of knee osteoarthritis patients. A two-step test before TKA and 3m-TUG before TKA can be used as motor function indicators to predict LS improvement. This study provides useful information for setting the goal for rehabilitation prior to surgery.
Quality Evaluation of Randomized Controlled Trials of Rhodiola Species: A Systematic Review

Background Rhodiola is a worldwide used medicinal plant for its various medicinal functions, and the number of randomized controlled trials (RCTs) of Rhodiola is increasing in recent years. This study aims to evaluate the reporting quality and risk of bias of the current RCT reports of different Rhodiola species. Methods Six databases including Embase, PubMed, Web of Science, the Cochrane Library, ClinicalTrial.gov, and China National Knowledge Infrastructure were searched to identify RCTs that used Rhodiola as a single intervention and were published in English or Chinese from inception to December 2020. The Consolidated Standards of Reporting Trials (CONSORT) 2010 statement was used as the checklist for assessment, and a scoring system was applied to the evaluation of RCTs. Score 0 represents no reporting or inadequate reporting, and score 1 represents adequate reporting. The risk of bias of the included studies was also assessed using the Cochrane Risk of Bias tool. Results A total of 39 RCTs were included in this study, including 23 RCTs of Rhodiola rosea (R. rosea), 8 RCTs of Rhodiola crenulata (R. crenulata), and 8 RCTs of Rhodiola wallichiana (R. wallichiana). None of the included studies met all the CONSORT statement criteria, and the reporting quality of RCTs of the three Rhodiola species was all generally poor. Based on the risk of bias assessment, the majority of included studies were judged to have an unclear risk of bias in most domains due to inadequate reporting. Conclusions There is inadequate reporting among the included RCTs of different Rhodiola species, and RCTs of Rhodiola with higher reporting quality and better methodological quality are needed.
Third-harmonic spectroscopy of electric and magnetic resonances in all-dielectric oligomers.

We perform third harmonic generation (THG) spectroscopy of silicon nanodisk oligomers to reveal the contributions of magnetic and electric dipolar resonances to the thirdorder nonlinearity. Due to the local field enhancement of the pump beam upon excitation of the oligomer resonances, the THG is strongly enhanced with respect to the bulk crystalline silicon. By changing the oligomer geometry we bring both resonances to a partial overlap, which causes a strong THG enhancement for wavelengths of the strongest overlap. This effect is explained in the framework of constructive interference of the third harmonic signal generated by the electric and magnetic dipolar resonances.
Interstitial Cells of Cajal: Potential Targets for Functional Dyspepsia Treatment Using Medicinal Natural Products

Introduction The pathophysiology of functional dyspepsia (FD) remains uncertain, but the interstitial cells of Cajal (ICCs), pacemakers that regulate gastrointestinal motility, are garnering attention as key modulators and therapeutic targets in FD. This review comprehensively discusses the involvement of ICCs in the pharmacologic actions of FD and as therapeutic targets for herbal products for FD. Methods A search of the literature was performed using PubMed by pairing “interstitial cells of Cajal” with “medicinal plant, herbal medicine, phytotherapy, flavonoids, or traditional Chinese medicine (TCM). ” Results From the 55 articles screened in the initial survey, 34 articles met our study criteria. The search results showed that herbal products can directly depolarize ICCs to generate pacemaker potentials and increase the expression of c-kit and stem cell factors, helping to repair ICCs. Under certain pathological conditions, medicinal plants also protect ICCs from oxidative stress and/or inflammation-induced impairment. Two representative herbal decoctions (Banhasasim-tang, 半夏泻心汤, and Yukgunja-tang, 六君子汤) have been shown to modulate ICC functions by both clinical and preclinical data. Conclusion This review strongly indicates the potential of herbal products to target ICCs and suggests that further ICC-based studies would be promising for the development of FD treatment agents.
Inhibitory Control Deficits in Children with Tic Disorders Revealed by Object-Hit-and-Avoid Task

Background Tic disorders may reflect impaired inhibitory control. This has been evaluated using different behavioural tasks, yielding mixed results. Our objective was to test inhibitory control in children with tics through simultaneous presentation of multiple, mobile stimuli. Methods Sixty-four children with tics (mean age 12.4 years; 7.5-18.5) were evaluated using a validated robotic bimanual exoskeleton protocol (Kinarm) in an object-hit-and-avoid task, in which target and distractor objects moved across a screen and participants aimed to hit only the targets while avoiding distractors. Performance was compared to 146 typically developing controls (mean age 13 years; 6.1-19.9). The primary outcome was the percentage of distractors struck. Results ANCOVA (age as covariate) showed participants struck significantly more distractors (participants without comorbid ADHD, 22.71% [SE 1.47]; participants with comorbid ADHD, 23.56% [1.47]; and controls, 15.59% [0.68]). Participants with comorbid ADHD struck significantly fewer targets (119.74 [2.77]) than controls, but no difference was found between participants without comorbid ADHD (122.66 [2.77]) and controls (127.00 [1.28]). Participants and controls did not differ significantly in movement speed and movement area. Just over 20% of participants with tics fell below the age-predicted norm in striking distractors, whereas fewer than 10% fell outside age-predicted norms in other task parameters. Conclusions In children with tics (without comorbid ADHD), acting upon both targets and distractors suggests reduced ability to suppress responses to potential triggers for action. This may be related to increased sensorimotor noise or abnormal sensory gating.
Alterations in the Plasma and Red Blood Cell Properties in Patients with Varicose Vein: A Pilot Study

The varicose vein results from the inefficient functioning of the valves in the lower limb veins, making the blood flow slow down and leading to blood stasis and hypoxia. This type of vein dysfunction might be a result of the development of oxidative stress. We compared oxidative stress markers in the plasma and erythrocytes obtained from peripheral veins and varicose veins in the same patients (glutathione, nonenzymatic antioxidant capacity (NEAC), catalase (CAT) and acetylcholinesterase (AChE) activity, thiols, thiobarbituric acid-reactive substance (TBARS), and protein carbonyls). We found a decrease in NEAC in the plasma obtained from the varicose veins compared to the peripheral veins. We detected a decrease in thiols in the plasma, hemolysate, and plasma membranes and increase in protein carbonyl compounds and TBARS levels in the varicose veins. These changes were accompanied by a decrease in CAT and AChE activity. For the first time, our results show changes in the plasma, erythrocyte membrane, and hemolysate protein properties in varicose vein blood in contrast to the plasma and erythrocytes in peripheral vein blood from the same patients. The increased oxidative stress accompanying varicose vein disease might result from the local inefficiency of the antioxidant defense system.
Association between Lipid Profiles and Serum Urate: A Cross-Sectional Study in Southwestern China

Objective The relationship between lipid profiles and serum urate has not been fully investigated. This study aims to investigate the sex- and age-specific association between lipid profiles and serum urate. Methods This was a cross-sectional study involving 122,351 participants aged 18–99 years from a check-up centre in Southwestern China. Generalized additive models and smooth curve fitting were conducted to explore the association between components of lipid profiles and serum urate. Furthermore, multivariate linear and logistic regression models were also performed. Results In generalized additive models, the fitted smoothing curves showed that serum urate fluctuated in a small range with total cholesterol, LDL-C, or HDL-C raising. After adjusting for confounders, the differences in serum urate progressively increased with raising serum triglycerides quartiles. The likelihood (odds ratio, OR) for developing serum urate > 420 μmol/L significantly increased in the highest quartile of triglycerides than in the lowest quartile, in hypertriglyceridemia than in normal triglycerides, and with 1 mmol/L increment in triglycerides in all sex- and age-specific groups. Furthermore, the increased OR (95% confidence interval) was higher in females than in males compared with their respective controls. Conclusions Serum urate and the likelihood for developing serum urate >420 μmol/L increased with triglycerides raising. Females were in a higher likelihood for developing serum urate >420 μmol/L than males with raising triglycerides. With changes in total cholesterol, LDL-C, or HDL-C, serum urate fluctuated in a small range.
Design of a Real-Time Monitoring System for Smoke and Dust in Thermal Power Plants Based on Improved Genetic Algorithm

The major health hazards from smoke and dust are due to microscopic fine particles present in smoke as well as in dust. These fine particles, which are microscopic in nature, can penetrate into human lungs and give rise to a range of health problems such as irritation in eyes, a runny nose, throat infection, and chronic cardiac and lung diseases. There is a need to device such mechanisms that can monitor smoke in thermal power plants for timely control of smoke that can pollute air and affects adversely the people living nearby the plants. In order to solve the problems of low accuracy of monitoring results and long monitoring time in conventional methods, a real-time smoke and dust monitoring system in thermal power plants is proposed, which makes use of modified genetic algorithm (GA). The collection and calibration of various monitoring parameters are accomplished through sampling control. The smoke and dust emission real-time monitoring subsystems are employed for the monitoring in an accurate manner. A dual-channel TCP/IP protocol is used between remote and local controlling modules for secure and speedy communication of the system. The generic GA is improved on the basis of the problem statement, and the linear programming model is used to avoid the defect of code duplication with genetic operations. The experimental results show that the proposed smoke and dust monitoring system can effectively improve the accuracy of the monitoring results and also reduce the time complexity by providing solutions in a faster manner. The significance of the proposed technique is to provide a reliable basis for the smoke and dust emission control of thermal power plants for safeguarding the human health.
Idiopathic pulmonary vein thrombosis treated with apixaban

Pulmonary vein thrombosis (PVT) is a rare clinical finding that is potentially fatal and with an unknown incidence rate as known cases exist predominantly in case reports. We present the case of a 58‐year‐old female who reported sudden onset of chest pain, shortness of breath, and dyspnoea on exertion. A computed tomography (CT) pulmonary angiogram was negative for evidence of pulmonary embolism; however, it did demonstrate the evidence of thrombosis of the right lower lobe segmental pulmonary vein. She had no identifiable aetiologies for her PVT; therefore, she was diagnosed with idiopathic PVT and was treated successfully with apixaban. This case represents the 14th incidence of idiopathic PVT in the current body of medical literature and the first case of successful treatment with apixaban.
Non-surgical correction of gummy smile using temporary skeletal mini-screw anchorage devices: A systematic review

Background There are no studies that have systematically reviewed randomized control trials and/or prospective cohort studies that have assessed the significance of temporary skeletal mini-screw anchorage devices (TSAD) for the correction of gummy-smile. The aim of the present systematic review was to assess the significance of non-surgical correction of gummy smile using TSAD. Material and Methods The addressed focused question was “Are temporary skeletal mini-screw anchorage devices effective for the correction of gummy smile? ” Indexed databases were searched up to and including May 2020. Different combinations of the following key-indexing terms were used: anchorage; gummy smile, mini-screw; orthodontic; and vertical maxillary excess. The literature search was performed without time and language barriers. Randomized clinical trials and prospective cohort studies that addressed the focused questions were included. Risk of bias was assessed using the Downs and Black and Cochran collaboration tools. Letters to the Editor, commentaries, case-reports/series and articles published in non-indexed databases were excluded. Results The initial search yielded 2118 studies out of which, four studies met the inclusion criteria and were processed for data extraction. All studies had a prospective research design. One study was a clinical trial and 3 had a non-randomized design. Results of the clinical trial showed no statistically significant difference in the extent of intrusion between the test- and control-groups. The non-randomized studies showed that TSAD are useful in reducing deep overbite. All studies had a high risk of bias. Conclusions The TSAD are an effective and practical option in facilitating reduction of excessive gingival display or gummy-smile. However, further long-term follow-up, well-designed and power-adjusted clinical trials are warranted in this regard. Key words:Anchorage, Excessive gingival display, Gummy-smile, Mini-screw.
Improving the Completion Rate of Home Care Skills for Parents of Preterm Infants

The survival rate of preterm infants in Taiwan has been on the rise in the last decade, and they must be taken care of with parents who possess good care skills after returning home. However, it is extremely difficult to provide parents with complete care guidance in an intensive care unit with high disease complexity and limited visiting hours. In this project, we conducted a situational analysis of parents of preterm infants weighing 1,500-2,100 g at 28-36 weeks and found that they had a high demand for knowledge about care but a low completion rate of performing care skills after receiving nursing guidance. The reasons were as follows: 1. The nurses did not understand the care resource model; 2. Lack of care manuals and standard operating procedures for health education guidance; 3. The promotion of the support group guidance program was not effective; and 4. Care audit and monitoring processes were not established. Therefore, the following should be developed: 1. Care manuals for parents of preterm infants; 2. Nursing guidance standards; 3. Care record form for caregiving consistency; and 4. Care audit feedback form. After the project, the completion rate of parental care skills increased from 37.1% before the improvement to 81.6%. The project thus improved the completion rate of parents’ care skills for preterm infants, continued the concept of care and patient safety goals of the nursing team, and achieved a triple win for doctors, nurses, and patients, thereby increasing parental confidence in the care of preterm infants. It is hoped that the results can assist parents of preterm infants in meeting their various needs. Review Article
Production of highly valued vegetable juice by osmotic distillation technique: Optimization of process parameters

Production of Highly Valued Vegetable Juice by Osmotic Distillation Technique: Optimization of Process Parameters Loredana Liguori, Paola Russo, Donatella Albanese* a Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Salerno, Italy b Department of Chemical Engineering Materials Environment, Sapienza University of Rome, Via Eudossiana 18, 00184 Rome, Italy dalbanese@unisa.it
Keypoint Matching for Point Cloud Registration Using Multiplex Dynamic Graph Attention Networks

The registration of point clouds is a key ingredient of LiDAR-based SLAM systems and mapping approaches. A challenging task in this context is finding the right data association between 3D points. This paper proposes a novel and flexible graph network architecture to tackle the keypoint matching problem in an end-to-end fashion. Each layer of our multiplex dynamic graph attention network (MDGAT) utilizes an attention mechanism to dynamically construct a multiplex graph and reasons about the contextual information based on the point cloud data. It enriches the feature representation by recovering local information and by aggregating information along with the connections. We also design a scan matcher called MDGAT-matcher, which treats the registration problem as an optimal transport problem and uses the predictions of MDGAT as the cost. It builds upon sparse keypoints extracted from pairs of LiDAR scans. Eventually, MDGAT-matcher finds high-quality correspondences and at the same time handles non-matching points appropriately. We train our matcher using a novel gap loss guiding the network to learn a discriminative cognition about matching and non-matching 3D points. We thoroughly test our approach on the KITTI odometry benchmark. The experiments presented in this paper suggest that our approach outperforms state-of-the-art matching approaches and achieves a substantial improvement.
Awareness level of dentists and dental students about radiation doses of dental imaging methods

Background: To measure the knowledge levels of dentists and dental students about radiation doses of dental imaging techniques. Materials and Methods: A structured questionnaire containing 13 questions was conducted to 251 participants (168 dentists and 83 dental students). The first 6 questions were related to their personal and professional information, and the remaining 7 questions were about the participants’ radiation education and knowledge about radiation doses. Chi-square test was used to determine the relationship between categorical variables, and P < 0.05 was considered statistically significant. Results: The data from 144 (57.4%) women and 107 (42.6%) men were obtained. Gender was not effective on knowledge about radiation doses during dental imaging (p = 0.222). The knowledge of dentists working at the university was statistically higher than those working in the state hospital or private dental offices (p < 0.001). Of the participants, 43.4% (n = 109) stated that the craniofacial mode of cone beam computerized tomography radiates less radiation than the actual dose range, while 32.7% (n = 82) said they had no idea. Conclusion: Most of the dentists and dental students underestimated the actual radiation doses of dental imaging techniques. The dental curriculum should be revised to emphasize radiation protection during imaging. In addition, compulsory vocational postgraduate courses should be organized.