Miracle-dz/UniFAR-FTUs huggingface dataset:
Dual-scale categorization based deep learning to evaluate programmed cell death ligand 1 expression in non-small cell lung cancer

Abstract In precision oncology, immune check point blockade therapy has quickly emerged as novel strategy by its efficacy, where programmed death ligand 1 (PD-L1) expression is used as a clinically validated predictive biomarker of response for the therapy. Automating pathological image analysis and accelerating pathology evaluation is becoming an unmet need. Artificial Intelligence and deep learning tools in digital pathology have been studied in order to evaluate PD-L1 expression in PD-L1 immunohistochemistry image. We proposed a Dual-scale Categorization (DSC)-based deep learning method that employed 2 VGG16 neural networks, 1 network for 1 scale, to critically evaluate PD-L1 expression. The DSC-based deep learning method was tested in a cohort of 110 patients diagnosed as non-small cell lung cancer. This method showed a concordance of 88% with pathologist, which was higher than concordance of 83% of 1-scale categorization-based method. Our results show that the DSCbased method can empower the deep learning application in digital pathology and facilitate computer-aided diagnosis.
Shock Tube and Modeling Study of Chemical Ionization in the Oxidation of Acetylene and Methane Mixtures

ABSTRACT Chemical ionization during the oxidation of methane and acetylene is experimentally and theoretically studied behind reflected shock waves over a wide temperature range and atmospheric pressure. The results of experimental measurements of the concentration of free electrons by microwave interferometry and electric probe method during the oxidation of acetylene and methane behind reflected shock waves are presented. A detailed kinetic model of the process of chemical ionization was developed. The results of experimental measurements and kinetic simulations are in good qualitative and quantitative agreement. The kinetic model of chemical ionization makes it possible to improve the kinetic description of the experimentally measured time histories of free electrons for the hydrocarbons studied.
Adult stem cells in endometrial regeneration: Molecular insights and clinical applications

Endometrial damage is an important cause of female reproductive problems, manifested as menstrual abnormalities, infertility, recurrent pregnancy loss, and other complications. These conditions are collectively termed “Asherman syndrome” (AS) and are typically associated with recurrent induced pregnancy terminations, repeated diagnostic curettage and intrauterine infections. Cancer treatment also has unexpected detrimental side effects on endometrial function in survivors independently of ovarian effects. Endometrial stem cells act in the regeneration of the endometrium and in repair through direct differentiation or paracrine effects. Nonendometrial adult stem cells, such as bone marrow‐derived mesenchymal stem cells and umbilical cord‐derived mesenchymal stem cells, with autologous and allogenic applications, can also repair injured endometrial tissue in animal models of AS and in human studies. However, there remains a lack of research on the repair of the damaged endometrium after the reversal of tumors, especially endometrial cancers. Here, we review the biological mechanisms of endometrial regeneration, and research progress and challenges for adult stem cell therapy for damaged endometrium, and discuss the potential applications of their use for endometrial repair after cancer remission, especially in endometrial cancers. Successful application of such cells will improve reproductive parameters in patients with AS or cancer. Significance: The endometrium is the fertile ground for embryos, but damage to the endometrium will greatly impair female fertility. Adult stem cells combined with tissue engineering scaffold materials or not have made great progress in repairing the injured endometrium due to benign lesions. However, due to the lack of research on the repair of the damaged endometrium caused by malignant tumors or tumor therapies, the safety and effectiveness of such stem cell‐based therapies need to be further explored. This review focuses on the molecular insights and clinical application potential of adult stem cells in endometrial regeneration and discusses the possible challenges or difficulties that need to be overcome in stem cell‐based therapies for tumor survivors. The development of adult stem cell‐related new programs will help repair damaged endometrium safely and effectively and meet fertility needs in tumor survivors.
Genome-wide association mapping reveals race-specific SNP markers associated with anthracnose resistance in carioca common beans

Brazil is the largest consumer of dry edible beans (Phaseolus vulgaris L.) in the world, 70% of consumption is of the carioca variety. Although the variety has high yield, it is susceptible to several diseases, among them, anthracnose (ANT) can lead to losses of up to 100% of production. The most effective strategy to overcome ANT, a disease caused by the fungus Colletotrichum lindemuthianum, is the development of resistant cultivars. For that reason, the selection of carioca genotypes resistant to multiple ANT races and the identification of loci/markers associated with genetic resistance are extremely important for the genetic breeding process. Using a carioca diversity panel (CDP) with 125 genotypes and genotyped by BeadChip BARCBean6K_3 and a carioca segregating population AM (AND-277 × IAC-Milênio) genotyped by sequencing (GBS). Multiple interval mapping (MIM) and genome-wide association studies (GWAS) were used as mapping tools for the resistance genes to the major ANT physiological races present in the country. In general, 14 single nucleotide polymorphisms (SNPs) showed high significance for resistance by GWAS, and loci associated with multiple races were also identified, as the Co-3 locus. The SNPs ss715642306 and ss715649427 in linkage disequilibrium (LD) at the beginning of chromosome Pv04 were associated with all the races used, and 16 genes known to be related to plant immunity were identified in this region. Using the resistant cultivars and the markers associated with significant quantitative resistance loci (QRL), discriminant analysis of principal components (DAPC) was performed considering the allelic contribution to resistance. Through the DAPC clustering, cultivar sources with high potential for durable anthracnose resistance were recommended. The MIM confirmed the presence of the Co-14 locus in the AND-277 cultivar which revealed that it was the only one associated with resistance to ANT race 81. Three other loci were associated with race 81 on chromosomes Pv03, Pv10, and Pv11. This is the first study to identify new resistance loci in the AND-277 cultivar. Finally, the same Co-14 locus was also significant for the CDP at the end of Pv01. The new SNPs identified, especially those associated with more than one race, present great potential for use in marker-assisted and early selection of inbred lines.
Association between Thyroid Function and Prognosis of COVID-19: A Retrospective Observational Study

ABSTRACT Background: Coronavirus disease 2019 (COVID-19) is a severe infectious illness. It has been reported that COVID-19 has an effect on thyroid function. However, the association between thyroid function and prognosis of COVID-19 is still unclear. Methods: This retrospective study included patients with COVID-19 admitted to Tongji Hospital in Wuhan from January 28 to April 4, 2020. Demographic, epidemiological, clinical, laboratory, treatment, and outcome data were collected from patients with laboratory-confirmed COVID-19. Patients without history of thyroid disease who had a thyroid function test at admission were enrolled in the final analysis. Risk factors of in-hospital death were explored using univariable and multivariable Cox regression analyses. Survival differences were assessed with Kaplan–Meier curves and log-rank test. Results: A total of 127 patients were included in this study, with 116 survivors and 11 non-survivors. The serum levels of thyroid stimulating hormone (TSH) [0.8 (0.5–1.7) vs. 1.9 (1.0–3.1) μIU/mL, P = . 031] and free triiodothyronine (FT3) [2.9 (2.8–3.1) vs. 4.2 (3.5–4.7) pmol/L, P < . 001] were lower in non-survivors than in survivors, and a low FT3 state (defined as FT3 < 3.1 pmol/L) at admission accounted for a higher proportion in non-survivors than in survivors (72.7% vs. 11.2%, P < .001). Univariate Cox regression analysis showed that FT3 level (HR 0.213, 95% CI: 0.101–0.451, P < .001) and the low FT3 state (HR 14.607, 95% CI: 3.873–55.081, P < .001) were negatively and positively associated with the risk of in-hospital death, respectively. Furthermore, multivariate Cox regression analysis revealed that a low FT3 state was associated with an increased risk of in-hospital death after adjusting for confounding factors (HR 13.288, 95% CI: 1.089–162.110, P = .043). Moreover, Kaplan-Meier curves indicated a lower survival probability in COVID-19 patients with a low FT3 status. Conclusion: Serum FT3 level is lower in non-survivors among moderate-to-critical patients with COVID-19, and the low FT3 state is associated with an increased risk of in-hospital mortality of COVID-19.
Potential of Sorghum Husk Extracts as a Natural Functional Dye for Wool Fabrics

We report a novel application of sorghum husk extracts (SHE) as a natural functional dye for wool fabrics. Sorghum husk is an abundant, cheap and readily available agricultural byproduct. A small proportion of sorghum husk has been used to extract food colorants. In order to add value to sorghum and decrease environmental pollution, a number of investigations need to be undertaken to explore newer application for the husk. This paper investigated the stability of SHE, the colorfastness, UV-protection and fluorescence properties of dyed wool fabrics with SHE by different dyeing methods. SHE had good thermal and pH stability suitable for the dyeing and finishing processes of textiles. Wool fabrics dyed directly or with Al3+ and Fe2+ mordant demonstrated good colorfastness to washing, to rubbing, to wet ironing and acceptable colorfastness to light. The dyed wool fabrics showed good UV-protection and fluorescence properties. After 30 home laundering cycles, the UV-Protection Factor (UPF) and fluorescence int.
Cardiovascular safety of febuxostat compared to allopurinol for the treatment of gout: A systematic and meta‐analysis

The cardiovascular safety of febuxostat compared to allopurinol for the treatment of gout remains equivocal. Febuxostat had a better safety outcome compared with allopurinol. In this systematic review and meta‐analysis, we searched MEDLINE and Embase for articles published between March 1, 2000 and April 4, 2021, without any language restrictions. We did a systematic review and meta‐analysis of included clinical trials to evaluate the cardiovascular safety of febuxostat compared to allopurinol for treatment of chronic gout. Two reviewers independently selected studies, assessed study quality, and extracted data. Risk ratios were calculated with random effects and were reported with corresponding 95% confidence intervals (CI). From 240 potentially relevant citations, 224 papers were excluded; 16 studies were ultimately included in the analysis. Febuxostat had a better safety outcome compared with allopurinol，which was the composite of urgent coronary revascularization (OR: 0.84, 95% CI: 0.77–0.90, p < .0001) and stroke (OR: 0.87, 95% CI: 0.79–0.97, p = .009). However, that difference was not found in nonfatal myocardial infarction (OR: 0.99, 95% CI: 0.80–1.22, p = .91), cardiovascular related mortality (OR: 0.98, 95% CI: 0.69–1.38, p = .89) and all‐cause mortality (OR: 0.93, 95% CI: 0.75–1.15, p = .52). No significant differences in cardiovascular related mortality and all‐cause mortality were observed across any subgroup. This meta‐analysis adds new evidence regarding the cardiovascular safety of febuxostat in patients. Initiation of febuxostat in patients was not associated with an increased risk of death or serious cardiovascular related adverse events compared with allopurinol.
2,4-Furfurylidene-D-sorbitol and its tetra-methyl ether: synthesis, conformational studies, and radical scavenging activity

The structure of 1-[2-(furan-2-yl)-5-hydroxy-6-(hydroxymethyl)-1,3-dioxan-4-yl]ethane-1,2-diol] (2,4-furfurylidene-D -sorbitol) and its tetra-methyl ether was established by a detailed NMR analysis. The conformational structure for both compounds was confirmed by in silico studies based both on Density Functional Theory (DFT) and on classical molecular dynamics approaches. The scavenging activity against hydroxyl radicals (•OH) of compounds was established by the 2-deoxyribose degradation assay.
Sex Differences in Rotator Cuff Muscles’ Response to Various Work-Related Factors

OCCUPATIONAL APPLICATIONS Despite the frequency and cost of rotator cuff injuries among male and female workers, very little is known about the strength, endurance, and perceived exertion and electromyographic response of rotator cuff muscles to different exertion levels. In this study, sex differences were studied using muscle-specific maximal and submaximal exertions of the supraspinatus, infraspinatus, and teres minor muscles. Females showed lower strength and endurance, but higher muscle activity and perceived exertion compared to males. The baseline data presented in this paper can assist ergonomic practitioners in determining the worker capacity to ensure that physically-demanding shoulder exertions can be performed without incurring injurious stress. Such data is also essential to establish population norms for the better design of workplace tasks. TECHNICAL ABSTRACT Background: Baseline strength, endurance, perceived exertion, and muscle activity data are essential to characterize sex-specific responses of the rotator cuff muscles to the workplace tasks to minimize risk of injury due to overexertion. Purpose: This study was conducted to measure sex differences in strength, endurance time, activity, fatigue, and perceived exertion for the rotator cuff muscles. Method: Muscle-specific maximum voluntary contractions (MVCs) were used to measure the maximum torque for the supraspinatus, infraspinatus, and teres minor muscles among 10 male and 10 female participants. Four submaximal exertions (15, 30, 45, and 60% MVC) were used to measure differences in endurance time, muscle activation, fatigue, and perceived exertion between sexes. Surface electromyography was used to measure muscle activity and fatigue. Results: Strength was the highest for the infraspinatus followed by teres minor and supraspinatus regardless of sex. Strengths for females were 70, 50, and 48% that of males for the infraspinatus, supraspinatus, and teres minor muscles, respectively. Muscle activity was significantly higher for females than males during the sub-maximal exertions. Among males, muscles with higher activity developed fatigue faster. Females exhibited lower endurance during all sub-maximal exertions. Perceived exertion ratings showed an increasing trend with %MVC, and females exceeded an acceptable limit at lower %MVC levels compared to males. Conclusions: Sex differences observed in this study suggest that a safe level of %MVC level for females is approximately 15% lower compared to males.
Lessons learned from a pilot intuitive eating intervention for college women delivered through group and guided self-help: qualitative and process data

ABSTRACT Although disordered eating is prevalent in college women, most will not receive treatment, and existing approaches have limitations. Thus, novel and accessible approaches are warranted. However, few behavioral health interventions progress beyond initial implementation, underscoring the importance of feasibility and acceptability data to guide intervention development and refinement. Stakeholder perspectives can enrich these data, as they can highlight potential mechanisms to investigate in larger randomized-controlled trials (RCTs). The current study examined participant and leader feedback from an 8-week pilot intuitive eating (IE) intervention for college women with disordered eating delivered through group and guided self-help (GSH) modalities. Participants (N = 71) and leaders (N = 8) completed anonymous weekly surveys and exit questionnaires. Overall, the intervention was acceptable and feasible for both participants and leaders. Unique benefits of each modality, such as validation and support in group, and individualization and convenience in GSH, contributed to participant satisfaction and efficacy. Moreover, potential mechanisms of intervention effects, such as interoceptive awareness and self-compassion, were cited in both conditions, and should be explored in a future, fully-powered RCT. Areas for potential refinement include extending the intervention, assessing a hybrid treatment, online delivery, and careful design of a control condition to isolate the intervention’s mechanisms of change.
CO2 Capture in Biocompatible Amino Acid Ionic Liquids: Exploring the Reaction Mechanisms for Bimolecular Absorption Processes

CO2 capture at the production site represents one of the accessible ways to reduce its emission in the atmosphere. In this context, CO2 chemisorption is particularly advantageous and is often based on exploiting a liquid containing amino groups that can trap CO2 due to their propensity to react with it to yield carbamic derivatives. A well-known class of ionic liquids based on amino acid anions might represent an ideal medium for CO2 capture because, at difference with present implementations, they are known to be fully biocompatible. One of the problems is however the relatively low molar ratio of CO2 absorption. Increasing this ratio turns out to be possible by choosing appropriate anions. We present here a set of accurate computations to elucidate the possible reaction paths that allow the anion to absorb two CO2 molecules, thus effectively doubling the overall intake. An extensive exploration of some reaction mechanisms suggests that some of them might be quite efficient even under mild conditions.
Epicardial and Perihepatic Fat as Cardiometabolic Risk Predictors in Girls with Turner Syndrome: A Cardiac Magnetic Resonance Study

Objective: Turner syndrome (TS) patients are at high risk of cardiometabolic disorders. Cardiometabolic risk factors are more commonly related to visceral rather than total body adiposity. Adipocytokines have been explored as a potential link between obesity and obesity-related cardiometabolic dysfunction. This study explored the validity of epicardial fat-thickness (EFT) and perihepatic fat-thickness (PHFT) measurement as cardiometabolic-risk predictors in TS-girls in relation to standard obesity-indices and metabolic syndrome (MetS) components. Methods: Forty-six TS girls and twenty-five controls (10-16 years) were subdivided into two age-groups (10 to less than 13 and 13-16). Participants were assessed for body mass index (BMI) Z-scores, waist circumference (WC), total-fat mass (FM) and trunk-FM by bioimpedance-technique, EFT and PHFT by cardiovascular magnetic resonance, lipid-profile, homeostasis model assessment of insulin resistance (HOMA-IR), and serum chemerin. MetS was defined according to International Diabetes Federation criteria. Results: Overweight/obesity and MetS were detected in 45.7% and 37% of TS-girls respectively. BMI Z-score, WC, total-FM, trunk-FM, EFT and PHFT values were significantly higher in TS-age groups compared to age-matched control groups, being more pronounced in the older group when TS-girls had been exposed to estrogen. Dyslipidemia, higher HOMA-IR, chemerin, EFT and PHFT values were observed in lean-Turner compared to BMI-Z-matched controls. EFT and PHFT were significantly correlated with chemerin and several components of MetS. EFT at a cut-off-value of 6.20 mm (area under the curve=0.814) can predict MetS in TS-girls. Conclusion: TS-girls displayed an adverse cardiometabolic profile during late childhood and adolescence. EFT and PHFT are emerging cardiometabolic risk predictors in TS-patients. Excess EFT rather than total body adiposity may contribute to altered metabolic profile among lean-Turner patients.
Impact of the acute care surgery model on resident operative experience in emergency general surgery

Background: The acute care surgery (ACS) model has been shown to improve patient, hospital and surgeon-specific outcomes. To date, however, little has been published on its impact on residency training. Our study compared the emergency general surgery (EGS) operative experiences of residents assigned to ACS versus elective surgical rotations. Methods: Resident-reported EGS case logs were prospectively collected over a 9-month period across 3 teaching hospitals. Descriptive statistics were tabulated and group comparisons were made using χ2 statistics for categorical data and t tests for continuous data. Results: Overall, 1061 cases were reported. Resident participation exceeded 90%). Appendiceal and biliary disease accounted for 49.7% of EGS cases. Residents on ACS rotations reported participating in twice as many EGS cases per block as residents on elective rotations (12.64 v. 6.30 cases, p < 0.01). Most cases occurred after hours while residents were on call rather than during daytime ACS hours (78.8% v. 21.1%, p < 0.01). Senior residents were more likely than junior residents to report having a primary operator role (71.3% v. 32.0%, p < 0.01). Although the timing of cases made no difference in the operative role of senior residents, junior residents assumed the primary operator role more often during the daytime than after hours (50.0% v. 33.1%, p = 0.01). Conclusion: Despite implementation of the ACS model, residents in our program obtained most of their EGS operative experience after hours while on call. Although further research is needed, our study suggests that improved daytime access to the operating room may represent an opportunity to improve the quantity and quality of the EGS operative experience at our academic network.
A comparison of NMHC oxidation mechanisms using specified gas mixtures and trace-P field data

ion. Under tropospheric conditions, the H-abstraction channel accounts for less than 10% (Atkinson, 1994). Therefore, the OH-adduction channel is of primary interest. When OH is added to the aromatic ring, an intermediate OH-alkylbenzene adduct is produced, which decomposes by reacting with O2. The products include phenol, epoxidealkoxy radicals, bicycloalkyl radicals, peroxy radicals, benzene oxides/oxepins. The subsequent reactions of the radical species typically lead to the formation of unsaturated carbonyls, dicarbonyls, and epoxy-carbonyls. Benzene is by far the most abundant aromatic hydrocarbon. However, because of its low reactivity it is usually not of major importance in its impact on OH and other radical species. Instead, toluene and xylene typically have much larger impacts and thus have here been chosen to be representative of the aromatic family. The reason both toluene and xylene were selected is that they are quite different in their chemical reactivity. Toluene, to some extent, has the properties of alkanes, while xylene behaves more closely to an alkene under tropospheric conditions. But xylene does not react with either O3 or NO3 as the alkenes do.
Synthesis and biological evaluation of novel N-pyridylpyrazolecarboxamides containing benzothiazole

GRAPHICAL ABSTRACT ABSTRACT A series of novel N-pyridylpyrazolecarboxamides containing benzothiazole were designed and synthesized. The target compounds were identified by 1H NMR,13C-NMR, IR, high-resolution mass spectrum (HRMS) and elemental analysis. The bioactivities of the new compounds against oriental army worm (Mythimnaseparata) and diamond back moth (Plutellaxylostella) were evaluated. The results of bioassays indicated that some of the compounds showed good activitiesat the tested concentrations. Compound Ij showed 100% larvicidal activities against Plutellaxylostella at 2.5 mg/L, while the activity of Ij against Mythimnaseparata was 100% at 10 mg/L.