Miracle-dz/UniFAR-FTUs huggingface dataset:
Sub-Ångström-resolution MicroED Using a Direct Detection Camera

The recent development of microcrystal electron diffraction (MicroED) in electron cryo-microscopy (cryo-EM) has addressed many of the challenges of X-ray crystallography [1], filling a long-standing need in organic chemistry for rapid and accurate high-resolution structural characterization [2]. Like X-ray crystallography, this is also a diffraction technique requiring crystalline specimens, but because high energy electrons have a more favorable ration of elastic to inelastic scattering [3], MicroED can acquire data using crystals that are orders of magnitude smaller than those needed for X-ray crystallography— even as small as 50 nm in length [4]. Additionally, the instrumentation required for MicroED is readily available, as many chemistry and biology labs already have access to cryo-capable transmission electron microscopes (TEM).
Removal efficiency and mechanisms of formaldehyde by five species of plants in air-plant-water system

ABSTRACT The foliar uptake and transport rates of formaldehyde as well as the abilities of leaf extracts to breakdown formaldehyde were investigated to discuss the formaldehyde removal efficiency and mechanism by five species of plants from air. Results showed that formaldehyde could be transported from air via leaves and roots to rhizosphere water. When exposed to 0.56 mg·m−3 formaldehyde, the formaldehyde removal rate ranged from 18.64 to 38.47 μg·h−1g−1 FW (fresh weight). According to the mass balance in the air–plant–water system, the main mechanism of the formaldehyde loss was its breakdown in plant tissues caused by both enzymatic reaction and redox reaction. Higher oxidation potentials of the leaf-extracts of Wedelia chinensis and Desmodium motorium corresponded well to higher abilities to breakdown added formaldehyde than other plants. Based on the different abilities of fresh and boiled leaf-extracts to dissipate formaldehyde, the enzymatic reaction in Chenopodium album L. was the dominant mechanism while the redox reaction in Kochia scoparia (L.) Schrad. and Silene conoidea L. was the main formaldehyde breakdown mechanism when exposed to low-level formaldehyde in air. The redox mechanism suggested that the formaldehyde removal may be increased by an increasing level of reactive oxygen species (ROS) induced by the environmental stress.
Relating groundfish diversity and biomass to deepsea corals and sponges using trawl survey catch data

Deep-sea corals and sponges (DSCS) inhabit the world’s oceans and are often associated with high fish abundance. However, the precise nature and extent of any association is difficult to quantify and remains poorly understood. We investigated associations between DSCS and demersal fish using data from the Northwest Fisheries Science Center’s bottom trawl survey (2003-2015). General linear mixed models showed that average species density of groundfish was slightly higher and groundfish biomass slightly lower in tows with DSCS. Multivariate analyses were used to examine relationships among fish community structure, DSCS biomass, and environmental parameters (depth, latitude, bottom temperature). No strong correlations occurred between the community structure of groundfish and DSCS biomass; instead, bottom temperature and depth were the primary drivers of community composition. However, indicator species analysis also showed various species-specific associations with DSCS. Specifically, some flatfish species exhibited relationships with coral and sea pen biomass, whereas some rockfishes were associated with high sponge biomass. Our results provide information on the broad-scale associations among DSCS and demersal fishes that may be useful for developing studies focused on the functional value of DSCS as essential fish habitat and the role they play in groundfish life history and ecology.
Characterization of Oxide/Sulfide Molybdenum Hexagonal Rods

Molybdenum sulfide (MoS 2 ) has been traditionally synthesized through different techniques, always the studies on structures and properties are focus on its applications. Different structures have been advantageous in several applications, due to its morphology or size like mono-layer, bulk or in support in hydrogen evolution reaction catalysis, hydrodesulfurization catalysts, electrochemical intercalation, hydrogen storage, elastic and coating materials in Li batteries and tribology [1]. The process of synthesis in MoS 2 usually involves an in-situ or ex-situ sulfurization process when the last one often is from an oxide molybdenum compound. Molybdenum oxide or any precursor to molybdenum sulfide has to pass to sulfurized form, this step is very important because it gives the final MoS 2 compound and because the sulfurization process can modify the shape, morphology; and in consequences the properties of the material. In the past the purpose of sulfurization of structures was centered in the sulfurization from outside to the inside of the materials, usually, a partial sulfurization was explained to core-shell structures when in-side (core) was the non-sulfurized material and outside (shell) was the sulfurized material. This research brake whit this idea, and through XRD, TEM, and SEM characterization the sulfurization process in molybdenum oxide hexagonal bars was studied and investigated.
Synthesis routes to eliminate oxide impurity segregation and their influence on intergrain connectivity in K-doped BaFe2As2 polycrystalline bulks

The poor reproducibility of intergrain critical current density Jc in Fe-based superconductors is often believed to result from uncontrolled grain boundary (GB) connectivity degraded by extrinsic factors such as the local or global impurity concentration or GB porosity or cracks. Earlier we found that Ba and K can appear as oxide impurities at GBs, along with GB-wetting FeAs. In this study, we evaluated how the sample preparation environment and purity of the starting materials influence the polycrystalline Jc in K-doped BaFe2As2 (Ba122) bulks. Using a high-performance glovebox, the oxygen and water levels were significantly reduced, eliminating traces of FeAs. Oxide impurities and Ba (or K) segregation associated with oxygen in the starting materials were significantly reduced by using high purity starting materials. This combination essentially doubled the best Jc(4.2 K) values to 2.3 × 105 at self-field and 1.6 × 104A cm−2 at 10 T and analytical scanning transmission electron microscopy showed no GB or O segregation in the best samples, but did show dark Z-contrast and distinct nanoscale porosity. Our work shows that an inert synthesis environment and high purity K and Ba do reduce current-blocking oxygen impurity and GB impurity phases, allowing deeper exploration of the role of extrinsic and intrinsic GB blocking effects in controlling the Jc of polycrystalline Ba122.
Automated karyotyping of metaphase chromosome images based on texture features

Most common genetic disorders can be identified by chromosome analysis. Visual representation of chromosome analysis is done using karyotyping. In karyotyping the chromosome arranged in sorted order so that the genetic disorders in chromosome can be identified easily. Karyotype analysis is used to determine abnormal number of chromosomes or abnormal sized chromosomes. Many methods of chromosome analysis were proposed and most of them required human intervention at some point. The proposed method uses texture features for karyotyping. In this proposed method chromosomes classified into the Denver class chromosomes based on morphological features. Each chromosome from the Denver class is identified based on their texture features, extracted from Gray Level Co-occurence Matrix(GLCM). The selected features are trained and classified using ANN Classifier.
Frequency Support from a Variable-Speed Wind Turbine Generator Using Different Variable Droop Characteristics

Doubly-fed induction generators (DFIGs) are capable of boosting frequency response capability while preventing the rotor speed from stalling during under-frequency disturbances, by employing variable droop characteristics. However, the frequency response capability during over-frequency disturbances is shortened because the potential for storing the kinetic energy is inversely proportional to the variable droop characteristics used for under-frequency disturbances. This paper designs a frequency control method of a DFIG to boost the frequency response capability during over-frequency disturbances while preserving the frequency response capability during under-frequency disturbances, by employing different variable droop characteristics. The effectiveness of the proposed frequency control method is investigated in a test system. The investigation results under five scenarios with different load variations, wind power penetrations and wind conditions clearly demonstrate that the proposed frequency control method suppresses the maximum system frequency deviations. As such, the proposed frequency control method can provide an effective solution for the frequency control ancillary service of a power system with large integrations of wind energy.
Cellular responses mediated by the transcription factor STAT1 in murine inflammatory diseases

The intracellular transduction of interferon signals from the plasma membrane to the nucleus is mediated by signal transducer and activator of transcription 1 (STAT1) which acts in tetrameric form as a transcription factor in immune responses. In this project, the protomer exchange between STAT1 dimers was studied under kinetic aspects and this process was identified as a potential rate-limiting step in the STAT1 activation/inactivation cycle. The data support an alternative mechanism for the transition between the parallel and anti-parallel conformation of STAT1 dimers based on the dissociation and subsequent reassociation of protomers which does not require reciprocal interactions within the N-terminal domain dimer to stabilize an intermediate conformational state. However, binding to high-affinity STAT-specific target sequences, termed gamma-activated sites (GAS), critically interfered with the exchange dynamics. A tandem GAS element in the promoter of the human gene coding for the cytoskeletal protein ezrin was identified in silico as a putative STAT1 target sequence, and was confirmed to bind dimeric STAT1 on each motif to moderately induce gene transcription. However, mice carrying either an N-terminal substitution mutation of STAT1 affecting cooperative DNA binding or a complete functional knockout of the Stat1 gene did not present with altered expression of ezrin and moesin in bone marrow cells compared with mice expressing the wildtype molecule. In a model of myocardial infarction performed by ligation of the left anterior descending coronary artery, male mice expressing the IFNγ-irresponsive STAT1 mutant displayed higher survival rates, whereas females were protected from adverse cardiac remodelling in the early remodelling phase. The inflammatory infiltrate showed a mild increase in tyrosine-phosphorylated STAT1, while the pool of total STAT1 was significantly reduced in the infarcted areas of knockin animals as compared to their wildtype littermates. In experimental autoimmune encephalomyelitis used as a model for a T helper cell-induced autoimmune disease, cells obtained from lymphatic organs of STAT1-deficient animals at the time of disease onset were hyperproliferative and secreted high amounts of IFNγ and IL-17A. Injection of these mice with lipopolysaccharide during the induction phase of experimental autoimmune encephalomyelitis completely abolished this proliferative phenotype. In summary, the findings demonstrate the role of cooperative DNA binding and tetramer formation of STAT1 in orchestrating complex immunological processes, even in the absence of infectious agents and, furthermore, highlight the function of tyrosine-phosphorylated STAT1 as a key factor facilitating the cross-talk between innate and adaptive immunity.
Market Orientation, Competitive Advantage and Marketing Performance of Small Medium Enterprises (SMEs)

This study aims to analyze competitive advantage as a variable that mediates the effect of market orientation on marketing performance. This research population is 113,000 SMEs (Small And Medium Enterprises) located in Malang City, which are engaged in food processing, handicrafts, and clothing business units with an observation sample of 100 SMEs. The data analysis technique used in this study is Structural Equation Modeling. The results of this study indicate that SMEs' performance will increase if they can carry out processes and activities related to creating and satisfying customer needs. Besides, market-oriented SMEs contribute to competitive advantage by creating product uniqueness, product quality, and competitive prices, ultimately affecting the performance of SMEs. In order to improve SMEs' performance, efforts must be made to develop marketing strategies, such as paying attention to market orientation, focusing on customer orientation, competitor orientation, and inter-functional coordination, and developing or innovating new products.
Diagnostic pathways in multiple myeloma and their relationship to end organ damage: an analysis from the Tackling Early Morbidity and Mortality in Myeloma (TEAMM) trial

Multiple myeloma is associated with significant early morbidity and mortality, with considerable end organ damage often present at diagnosis. The Tackling EArly Morbidity and Mortality in Multiple Myeloma (TEAMM) trial was used to evaluate routes to diagnosis in patients with myeloma and the relationship between diagnostic pathways, time to diagnosis and disease severity. A total of 915 participants were included in the study. Fifty‐one per cent were diagnosed by direct referral from primary care to haematology; 29% were diagnosed via acute services and 20% were referred via other secondary care specialties. Patients diagnosed via other secondary care specialties had a longer diagnostic interval (median 120 days vs. 59 days) without an increase in features of severe disease, suggesting they had a relatively indolent disease. Marked intrahospital delay suggests possible scope for improvement. A quarter of those diagnosed through acute services reported >30 days from initial hospital consultation to haematology assessment. Participants diagnosed through acute services had poorer performance status (P < 0·0001) and higher burden of end organ damage (P < 0·0001) with no difference in the overall length of diagnostic pathway compared to those diagnosed by direct referral (median 59 days). This suggests that advanced disease in patients presenting through acute services predominantly reflects disease aggression.
Using Natural Language Preprocessing Architecture (NLPA) for Big Data Text Sources

During the last years, big data analysis has become a popular means of taking advantage of multiple (initially valueless) sources to find relevant knowledge about real domains. However, a large number of big data sources provide textual unstructured data. A proper analysis requires tools able to adequately combine big data and text-analysing techniques. Keeping this in mind, we combined a pipelining framework (BDP4J (Big Data Pipelining For Java)) with the implementation of a set of text preprocessing techniques in order to create NLPA (Natural Language Preprocessing Architecture), an extendable open-source plugin implementing preprocessing steps that can be easily combined to create a pipeline. Additionally, NLPA incorporates the possibility of generating datasets using either a classical token-based representation of data or newer synset-based datasets that would be further processed using semantic information (i.e., using ontologies). This work presents a case study of NLPA operation covering the transformation of raw heterogeneous big data into different dataset representations (synsets and tokens) and using the Weka application programming interface (API) to launch two well-known classifiers.
Environmental Influence on the Spatiotemporal Variability of Spawning Grounds in the Western Guangdong Waters, South China Sea

Spawning grounds occupy an important position in the supplementary population of fishery resources, especially in Western Guangdong waters (WGWs) in the northern South China Sea (SCS), where fishery resources are being depleted. This study investigated the environmental effects on the spatiotemporal variability of spawning grounds in WGWs, on the basis of generalized additive models (GAMs) and central spawning-ground gravity (CoSGG) by using satellite and in situ observations. Results showed that 57.2% of the total variation in fish-egg density in WGWs was explained. On the basis of stepwise GAMs, the most important factor was sea surface salinity (SSS), with a contribution of 32.1%, followed by sea surface temperature (SST), water depth, month, and chlorophyll a concentration (Chl-a), with contributions of 10.7%, 8.8%, 2.6%, and 2.6%, respectively. Offshore distance had slight influence on the model, explaining approximately 0.4% of the variation in fish-egg density. In summary, fish eggs in WGWs were mainly distributed in the area with SSS of 32.0–34.0 Practical Salinity Unit (PSU), SST of 24–27 °C, and depth of 0–18 m. CoSGG shifted eastwards by 0.38° N and northwards by 0.26° E from April to June. The distribution of spawning grounds in the WGW was affected by the Western Guangdong coastal current (WGCC), cyclonic circulation, the SCS warm current (SCSWC), and changes in the habitat environment (such as SST). Fish in WGWs tend to spawn in areas with a high seabed slope and steep terrain (near the Qiongzhou Strait).
Sky, sea, and forest islands: Diversification in the African leaf‐folding frog Afrixalus paradorsalis (Anura: Hyperoliidae) of the Lower Guineo‐Congolian rain forest

To investigate how putative barriers, forest refugia, and ecological gradients across the lower Guineo‐Congolian rain forest shape genetic and phenotypic divergence in the leaf‐folding frog Afrixalus paradorsalis, and examine the role of adjacent land bridge and sky‐islands in diversification.
HIGH INTENSITY LASER THERAPY ON PAIN IN PATIENTS WITH MYOFASCIAL TRIGGER POINTS

Purpose: to investigate the effect of HILT on pain intensity in patients with acute cervical MTrP in the upper trapezius muscle. methods: 50 patients (32 female and 18 male) having MTrP in the upper trapezius muscle from out-clinic of faculty of physical therapy BADR university, were participated in this study. Their ages ranged from 20 to 40 years old with body mass index less than 25 kg/m² They were assigned randomly into two equal groups; group (A) received traditional treatment only (transcutaneous electrical nerve stimulation (TENS), ultrasound massage (US) and stretch and exercise) , group B received HILT with traditional treatment. duration of treatment was 2 sessions/week for 4 weeks. Measurement of the visual analogue scale (VAS) was recorded before and at the end of intervention. Results: Results showed that there was significant difference between the two groups in the outcome measures in the post treatment assessment, but the HILT group (group B) showed a significant improvement than the control group (group A) at (p >0.001). Conclusion: HILT is an adjuvant physical therapy modality that may provide better outcomes for a patient with cervical MTrP.
Comparing the adoption of protective behaviors: The framing effects of national culture and hazard onset type

ABSTRACT On the basis of framing effect and protective action decision model, this study examines the differences in people's response to diverse hazard onset types (sudden or gradual) under different cultural frameworks (China and the United States) and the framing effects of culture and hazard onset type on people's perception and behavioral response. The data are derived from three questionnaire surveys on people's behavioral response to H7N9 and smog emergency in China and H1N1 in the United States. Results indicate that people with different cultures and diverse contexts of hazard onset type present substantial differences in risk perception, protective action perception, stakeholder perception, and behavioral expectations. Furthermore, culture and hazard onset type exert significant framing effects on people's three types of perception, reliance on official information sources, and intention to adopt protective actions. This research empirically verifies the existence of framing effect in culture and decision scenarios, thereby helping in developing different emergency communication strategies.
Virus – On the Edge of Art and Science, Human Beings, and Nature

Creative Arts Educ Ther (2020) 6(1):13–18 DOI: 10.15212/CAET/2020/6/7 Virus – On the Edge of Art and Science, Human Beings, and Nature Abstract In this article, the author shares his eastern and western perspectives on biomedicine, science and arts as well as his personal experiences during the coronavirus epidemics in China. Virus is described symbolically as a messenger on the edge of art and science, human beings and nature leading to a discussion over the sustainable development of human beings in harmony with nature. Keywords: Coronavirus epidemic, Covid-19, Sustainable development, Entropy, Art, Traditional Chinese medicine 摘要 本文作者分享了其在中国新冠肺炎疫情期间从生物医学，科学及艺术，东西方视角的思考和个人感受。 病毒被象征性地描述为处于艺术和科学，人类和自然边缘上的信使，从而引发出关于人类与自然和谐可持续发展的讨论。 关键词：冠状病毒疫情，肺炎，可持续发展，熵，艺术，中医
Revealing the complete mitochondrial genome of Thermophis baileyi Wall, 1907 (Reptilia: Colubridae) through the next-generation sequencing

Abstract The complete mitochondrial genome of Thermophis baileyi was sequenced using the next-generation sequencing (NGS) in the present study. The total length of the mitogenome was 17,355 bp, which was composed of 13 protein-coding genes, 22 transfer RNA (tRNA) genes, 2 ribosomal RNA (rRNA) genes (12s and 16s rRNA), and 2 control regions (CR I and CR II). The base composition was 32.4% for A, 23.8% for T, 30.2% for C, and 13.6% for G. Coding genes of each protein in the mtDNA had the same start and stop codons among three Thermophis species.
Research on Edge Detection Method Based on Improved HED Network

Aiming at the problem of rough and fuzzy edges generated by the current edge detection technology based on HED network, an improved edge detection method for HED network is proposed. First, the useful information captured by each convolutional layer of HED becomes rougher as the size of the acceptance field increases. The improved HED network makes use of all the information of the convolution layer to capture more targets in a larger range, or make the local boundaries of the targets possible. The improved HED makes full use of the multi-scale and multi-level information of the target to obtain high-precision and high-quality edge maps, which lays a good foundation for image segmentation.
Turkish Sentiment Analysis System via Ensemble Learning

Nowadays, sentiment analysis (SA) also known as opinion mining (OM) is widely used and has an impressive effect in many fields, such as marketing, politics, and even, company’s products are now adjusted based on users’ opinions. In this paper, a new efficient sentiment analysis system that supports the Turkish language has been introduced. In addition, as Turkish is an agglutinative language, which requires special processing, an efficient preprocessing model was also implemented as a part of the developed system. Several experiments using the challenging and benchmark “The Turkish movie reviews” dataset have been conducted, and it is obvious that the constructed approach can efficiently support the Turkish language and can achieve a quite good performance.