Miracle-dz/UniFAR-FTUs huggingface dataset:
Design and Analysis of Super Wideband Antenna for Microwave Applications

In this article, a compact concentric structured monopole patch antenna for super wideband (SWB) application is proposed and investigated. The essential characteristics of the designed antenna are: (i) to attain super-wide bandwidth characteristics, the proposed antenna is emerged from a traditional circular monopole antenna and has obtained an impedance bandwidth of 38.9:1 (ii) another important characteristic of the presented antenna is its larger bandwidth dimension ratio (BDR) value of 6596 that is accomplished by augmenting the electrical length of the patch. The electrical dimension of the proposed antenna is 0. 18λ×0. 16λ (λ corresponds to the lower end operating frequency). The designed antenna achieves a frequency range from 1.22 to 47.5 GHz with a fractional bandwidth of 190% and exhibiting S11 < −10 dB in simulation. For validating the simulated outcomes, the antenna model is fabricated and measured. Good conformity is established between measured and simulated results. Measured frequency ranges from 1.25 to 40 GHz with a fractional bandwidth of 188%, BDR of 6523 and S11 < −10 dB. Even though the presented antenna operates properly over the frequency range from 1.22 to 47.5 GHz, the results of the experiment are measured till 40 GHz because of the high-frequency constraint of the existing Vector Network Analyzer (VNA). The designed SWB antenna has the benefit of good gain, concise dimension, and wide bandwidth above the formerly reported antenna structures. Simulated gain varies from 0.5 to 10.3 dBi and measured gain varies from 0.2 to 9.7 dBi. Frequency domain, as well as time-domain characterization, has been realized to guide the relevance of the proposed antenna in SWB wireless applications. Furthermore, an equivalent circuit model of the proposed antenna is developed, and the response of the circuit is obtained. The presented antenna can be employed in L, S, C, X, Ka, K, Ku, and Q band wireless communication systems.
Supplementation With Dexmedetomidine for Transsphenoidal Resection of Pituitary Adenoma: A Meta-Analysis of Randomized Controlled Trials.

INTRODUCTION The effect of dexmedetomidine supplementation on hemodynamic stability for transsphenoidal resection of pituitary adenoma remains controversial. We conduct a systematic review and meta-analysis to explore the influence of dexmedetomidine supplementation on hemodynamic stability for transsphenoidal resection of pituitary adenoma. METHODS We have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through August 2020 for randomized controlled trials assessing the effect of dexmedetomidine supplementation on transsphenoidal resection of pituitary adenoma. RESULTS Four randomized controlled trials involving 160 patients were included in the meta-analysis. Overall, compared with the control group for transsphenoidal resection of pituitary adenoma, dexmedetomidine supplementation resulted in significantly reduced mean arterial pressure at 30 minutes [mean difference (MD), -26.62; 95% confidence interval (CI), -36.71 to -16.53; P < 0.00001], heart rate at 30 minutes (MD, -16.50; 95% CI, -32.48 to -0.53; P = 0.04), blood loss (MD, -112.57; 95% CI, -165.12 to -60.01; P < 0.0001), and fentanyl (MD, -154.13; 95% CI, -303.97 to -4.29; P = 0.04), but demonstrated similar incidence of nausea and vomiting (odds ratio, 0.37; 95% CI, 0.13-1.03; P = 0.06), and hypotension (odds ratio, 2.11; 95% CI, 0.49-9.22; P = 0.32). CONCLUSIONS Dexmedetomidine supplementation was effective in improving hemodynamic stability for transsphenoidal resection of pituitary adenoma.
Arachis hypogaea resveratrol synthase 3 alters the expression pattern of UDP-glycosyltransferase genes in developing rice seeds

The resveratrol-producing rice (Oryza sativa L.) inbred lines, Iksan 515 (I.515) and Iksan 526 (I.526), developed by the expression of the groundnut (Arachis hypogaea) resveratrol synthase 3 (AhRS3) gene in the japonica rice cultivar Dongjin, accumulated both resveratrol and its glucoside, piceid, in seeds. Here, we investigated the effect of the AhRS3 transgene on the expression of endogenous piceid biosynthesis genes (UGTs) in the developing seeds of the resveratrol-producing rice inbred lines. Ultra-performance liquid chromatography (UPLC) analysis revealed that I.526 accumulates significantly higher resveratrol and piceid in seeds than those in I.515 seeds and, in I.526 seeds, the biosynthesis of resveratrol and piceid reached peak levels at 41 days after heading (DAH) and 20 DAH, respectively. Furthermore, RNA-seq analysis showed that the expression patterns of UGT genes differed significantly between the 20 DAH seeds of I.526 and those of Dongjin. Quantitative real-time PCR (RT-qPCR) analyses confirmed the data from RNA-seq analysis in seeds of Dongjin, I.515 and I.526, respectively, at 9 DAH, and in seeds of Dongjin and I.526, respectively, at 20 DAH. A total of 245 UGTs, classified into 31 UGT families, showed differential expression between Dongjin and I.526 seeds at 20 DAH. Of these, 43 UGTs showed more than 2-fold higher expression in I.526 seeds than in Dongjin seeds. In addition, the expression of resveratrol biosynthesis genes (PAL, C4H and 4CL) was also differentially expressed between Dongjin and I.526 developing seeds. Collectively, these data suggest that AhRS3 altered the expression pattern of UGT genes, and PAL, C4H and 4CL in developing rice seeds.
Evaluation of Phenological Indicators for Optimizing Spring Southern Pine Beetle (Coleoptera: Curculionidae: Scolytinae) Trapping Surveys

Abstract Since 1987, as many as 16 southeastern US states participate in a 4 wk annual spring Dendroctonus frontalis (Zimmerman) (Coleoptera: Curculionidae) trapping survey. The purpose of the survey is to assess the current D. frontalis outbreak potential, and anticipate prevention and suppression needs for the coming yr. This prediction system relies on capturing the peak D. frontalis spring dispersal, thus timing of trap deployment is crucial. Forest managers traditionally attempt to deploy traps at the onset of flowering dogwood (Cornus florida L.; Cornaceae) bloom, which is commonly assumed to coincide with peak D. frontalis spring dispersal. The objective of this study is to examine the validity of dogwood bloom as an indicator of peak D. frontalis spring dispersal. Yr-round trapping data in 2014 and 2015 from Mississippi and Florida were used to identify peak D. frontalis and Thanasimus dubius (Fabricius) (Coleoptera: Cleridae) dispersal periods. Peak D. frontalis dispersal then was compared with dogwood blooming dates from the USA National Phenology Network and personal records. Then, both dogwood bloom dates and peak D. frontalis dispersal were compared with timing of actual historic state D. frontalis trapping efforts. We also compared peak D. frontalis dispersal with T. dubius peak dispersal, because T. dubius trap captures are used in the prediction model. Last, we examined the utility of extending the spring survey to 6 wk by comparing the 4 wk peak D. frontalis trap captures with a corresponding 6 wk peak. On average, mean onset of dogwood bloom occurred 3 wk after the peak 4 wk period of D. frontalis flight activity. The average T. dubius peak dispersal occurred 1.5 wk after peak D. frontalis dispersal. The 6 wk extension provided only a 12% overall average increase in D. frontalis trap captures. Eastern redbud (Cercis canadensis L.; Fabaceae) also had been suggested as a replacement trap deployment cue; therefore, eastern redbud and flowering dogwood blooming dates in 2019 were monitored on a Mississippi State University property in Oktibbeha County, Mississippi, USA. On this site eastern redbud trees bloomed on average 2.3 wk before the average bloom date of flowering dogwood trees.
Provision of Early Pregnancy Loss Care in New York Federally Qualified Health Centers

Background: Office-based early pregnancy loss (EPL) care is safe and suitable to Federally Qualified Health Centers (FQHCs); prevalence of provision in FQHCs is unknown. Methods: We conducted a mailed site-level survey of FQHCs in New York State (n = 405). Sites that offered prenatal care were eligible for analysis. Questions included provision of and barriers to providing EPL care options. Content analysis was used for write-in responses to barriers. We conducted bivariate analyses using Fisher’s Exact tests and risk ratios to investigate associations between EPL care provision and the independent variables site urbanicity, prenatal clinician type, and ultrasound access. Results: Of 181 mailings returned, 63 sites were eligible (response rate 44.7%); 88.9% provided expectant management, 53.9% medication management, and 23.8% uterine aspiration. Common barriers included lack of clinical infrastructure, poor ultrasound access, and insufficient training. Some held perceived barriers regarding uterine aspiration. Sites with regular ultrasound access were 1.85 times as likely to provide uterine aspiration as sites without regular ultrasound access (95% CI, 1.16–2.95). Conclusions: Few New York FQHCs provided comprehensive EPL care. Supporting FQHCs to overcome barriers may expand access to EPL treatment in primary care and increase continuity and patient centeredness.
Substrate-specific recognition of IKKs mediated by USP16 facilitates autoimmune inflammation

Ubiquitination regulates selective substrate recognition of IKKβ. The classic NF-κB pathway plays crucial roles in various immune responses and inflammatory diseases. Its key kinase, IKKβ, participates in a variety of pathological and physiological processes by selectively recognizing its downstream substrates, including p105, p65, and IκBα, but the specific mechanisms of these substrates are unclear. Hyperactivation of one of the substrates, p105, is closely related to the onset of inflammatory bowel disease (IBD) in Nfkb1-deficient mice. In this study, we found that IKKβ ubiquitination on lysine-238 was substantially increased during inflammation. Using mass spectrometry, we identified USP16 as an essential regulator of the IKKβ ubiquitination level that selectively affected p105 phosphorylation without directly affecting p65 or IκBα phosphorylation. Furthermore, USP16 was highly expressed in colon macrophages in patients with IBD, and myeloid-conditional USP16-knockout mice exhibited reduced IBD severity. Our study provides a new theoretical basis for IBD pathogenesis and targeted precision intervention therapy.
Silicon-Modified Carbohydrate Surfactants I: Synthesis of Siloxanyl Moieties Containing Straight-chained Glycosides and Amides

New siloxanyl-modified carbohydrate surfactants of the amide and glycoside type have been synthesized by coupling between defined as well as higher-molecular-weight siloxanes and carbohydrate structures via spacers of different lengths and hydrophilic power. Linear and branched monohydrogen di-, tri-, tetra- and penta-siloxanes and polyhydrogen siloxanes as well as mono- and di-saccharide lactone structures have been found to be good starting materials for the synthesis of amides, often in quantitative yield, whereas glycosides had to be prepared in low-yield multistep sequences including protection/deprotection steps. Selected strategies were applied to polysiloxanes yielding quantitatively a broad variety of carbohydrate-modified comb-like structures. The new substances were characterized by means of 13 C NMR spectroscopy, GC, capillary GC, GC-MS coupling and elemental analysis.
Tau Isoform-Driven CBD Pathology Transmission in Oligodendrocytes in Humanized Tau Mice

The aggregation of abnormally phosphorylated tau protein in neurons and glia is a neuropathological hallmark of several neurodegenerative disorders, collectively known as tauopathies. They are further subclassified based on the preferential pathological aggregation of three carboxyl-terminal repeat domains (3R) and/or 4R tau. Corticobasal degeneration (CBD) is a rare neurodegenerative disorder classified as a 4R tauopathy. In the present study, we extend analysis of CBD-tau cell-type specific pathology transmission with 3R and 4R tau isoform distinguishable changes. We use a humanized tau (hTau) mouse line, which overexpress all six human tau isoforms in a murine tau knockout background and perform intrastriatal inoculation of control and CBD-tau enriched human brain homogenate. We show that CBD-tau causes hyperphosphorylation of tau at Ser202 predominantly in oligodendrocytes. Next, we demonstrate the spread of tau pathology from striatum to the overlaying corpus callosum and further to the contralateral side. Finally, we demonstrate that the almost exclusive oligodendrocyte-based transmission of hyperphosphorylated tau is reflected in the endogenous 4R tau isoform expression and corresponds to subclassification of CBD as a 4R tauopathy. Additionally, we identify functional changes in oligodendrocytes reflected by myelin basic protein abnormalities upon CBD-tau inoculation. These changes are not observed in murine tau knockout mice lacking both human and murine tau. Our study presents not only in vivo tau isoform–driven region- and cell-specific tau pathology, but also underlines that tau pathology seeding and transmission might be oligodendrocyte-based. These results, which need to be extended to more cases, give new insights into why tauopathies might vary greatly in both histopathological and neuroanatomical patterns.
Does Urbanization Promote Regional Industrial Environmental Efficiency? A Comparison of Economic Development-Oriented Regions and Environmental Governance-Oriented Regions

The promotion of industrial environmental efficiency (IEE) has attracted considerable attention from scholars and policymakers. Previous studies have focused on the factors driving IEE without considering the leader-follower relationship between the two stages of IEE and have used aggregated indicators to detect the effect of urbanization on IEE. In this study, we open the “black box” of IEE and regard it as a serial system comprised of the economic development (ED) stage and the environmental governance (EG) stage. We select typical provinces belonging to the ED-oriented regions and EG-oriented regions for our analysis. We quantify IEE by using the slack-based model (SBM), decompose the effect of urbanization into four typical factors and detect the effect of the urbanization-related factors by using a tobit regression model. Next, we compare the effect of the urbanization-related factors in the different regions. The results show that overall, in 2011–2015, IEE in the different regions was low and fluctuating, and it increased in ED-oriented regions while remaining stable in EG-oriented regions. The IEE of the ED-oriented regions was always higher than that of the EG-oriented regions, with the gap increasing over time. The IEE of the two stages varied in each type of region. Urbanization-related factors had different effects on the IEE of the different stages in the two types of region, and the same factor had significantly different effects in different regions.
Optimal Topology Formation and Adaptation of Integrated Access and Backhaul Networks

With the increasing densification of cellular networks, it has become exceedingly difficult to provide traditional fiber backhaul access to each cell site, which is especially true for small cell base stations (SBSs). The increasing maturity of millimeter wave (mmWave) communication coupled with multiple-input-multiple-output (MIMO) and beamforming technologies has opened up the possibility of providing high-speed wireless backhaul to such cell sites. The third-generation partnership project (3GPP) is defining an integrated access and backhaul (IAB) architecture for the fifth-generation (5G) cellular networks, in which the same infrastructure and spectral resources are used for both the access and the backhaul. In IAB networks, SBSs, so-called IAB nodes, act either as relay nodes carrying the traffic through multiple hops from a macrocell to an end user and vice versa or as access points to serve user equipments (UEs) in their proximity. To this end, the topology of such IAB networks is essential to enable efficient traffic flow and minimize congestion or increase robustness to backhaul link failure. In this paper, we propose a topology formation algorithm together with methodologies to implement it in real networks and compare it with a standard random sequence approach as well as with an optimal topology obtained using dynamic programming. Our simulation results demonstrate that the proposed algorithm outperforms the random sequence approach by 26% on average in terms of lower bound of the network capacity and is up to 99.7% close to the optimal solution, while being significantly less complex.
Sodium-Based Batteries: In Search of the Best Compromise Between Sustainability and Maximization of Electric Performance

Till 2020 the predominant key success factors of battery development have been overwhelmingly energy density, power density, lifetime, safety, and costs per kWh. That is why there is a high expectation on energy storage systems such as lithium-air (Li-O2) and lithium-sulfur (Li-S) systems, especially for mobile applications. These systems have high theoretical specific energy densities compared to conventional Li-ion systems. If the challenges such as practical implementation, low energy efficiency, and cycle life are handled, these systems could provide an interesting energy source for EVs. However, various raw materials are increasingly under critical discussion. Though only 3 wt% of metallic lithium is present in a modern Li-ion cell, absolute high amounts of lithium demand will rise due to the fast-growing market for traction and stationary batteries. Moreover, many lithium sources are not available without compromising environmental aspects. Therefore, there is a growing focus on alternative technologies such as Na-ion and Zn-ion batteries. On a view of Na-ion batteries, especially the combination with carbons derived from food waste as negative electrodes may generate a promising overall cost structure, though energy densities are not as favorable as for Li-ion batteries. Within the scope of this work, the future potential of sodium-based batteries will be discussed in view of sustainability and abundance vs. maximization of electric performance. The major directions of cathode materials development are reviewed and the tendency towards designing high-performance systems is discussed. This paper provides an outlook on the potential of sodium-based batteries in the future battery market of mobile and stationary applications.
Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration

Significance Dry age-related macular degeneration (AMD) affects the vision of millions of people worldwide. There is currently no Food and Drug Administration–approved treatment for dry AMD. The inflammasome components NLRP3 and ASC have been implicated in the pathogenesis of dry AMD. We report that fluoxetine, which is approved for the treatment of clinical depression, directly binds the NLRP3 protein and prevents NLRP3-ASC inflammasome assembly and activation. Fluoxetine prevents the degeneration of retinal pigmented epithelium cells in an animal model of dry AMD. We also present evidence from a big data analysis of health insurance databases that fluoxetine use is associated with reduced risk of developing dry AMD. These studies identify a potential repurposing candidate for a prevalent cause of blindness. The atrophic form of age-related macular degeneration (dry AMD) affects nearly 200 million people worldwide. There is no Food and Drug Administration (FDA)-approved therapy for this disease, which is the leading cause of irreversible blindness among people over 50 y of age. Vision loss in dry AMD results from degeneration of the retinal pigmented epithelium (RPE). RPE cell death is driven in part by accumulation of Alu RNAs, which are noncoding transcripts of a human retrotransposon. Alu RNA induces RPE degeneration by activating the NLRP3-ASC inflammasome. We report that fluoxetine, an FDA-approved drug for treating clinical depression, binds NLRP3 in silico, in vitro, and in vivo and inhibits activation of the NLRP3-ASC inflammasome and inflammatory cytokine release in RPE cells and macrophages, two critical cell types in dry AMD. We also demonstrate that fluoxetine, unlike several other antidepressant drugs, reduces Alu RNA–induced RPE degeneration in mice. Finally, by analyzing two health insurance databases comprising more than 100 million Americans, we report a reduced hazard of developing dry AMD among patients with depression who were treated with fluoxetine. Collectively, these studies identify fluoxetine as a potential drug-repurposing candidate for dry AMD.
APOBEC1 mediated C-to-U RNA editing: target sequence and trans-acting factor contribution to 177 RNA editing events in 119 murine transcripts in vivo

Mammalian C-to-U RNA editing was described more than 30 years ago as a single nucleotide modification in APOB RNA in small intestine, later shown to be mediated by the RNA-specific cytidine deaminase APOBEC1. Reports of other examples of C-to-U RNA editing, coupled with the advent of genome-wide transcriptome sequencing, identified an expanded range of APOBEC1 targets. Here we analyze the cis-acting regulatory components of verified murine C-to-U RNA editing targets, including nearest neighbor as well as flanking sequence requirements and folding predictions. We summarize findings demonstrating the relative importance of trans-acting factors (A1CF, RBM47) acting in concert with APOBEC1. Using this information, we developed a multivariable linear regression model to predict APOBEC1 dependent C-to-U RNA editing efficiency, incorporating factors independently associated with editing frequencies based on 103 Sanger-confirmed editing sites, which accounted for 84% of the observed variance. Co-factor dominance was associated with editing frequency, with RNAs targeted by both RBM47 and A1CF observed to be edited at a lower frequency than RBM47 dominant targets. The model also predicted a composite score for available human C-to-U RNA targets, which again correlated with editing frequency.