Miracle-dz/UniFAR-FTUs huggingface dataset:
Normal and Persistent Genital Arousal in Women: New Perspectives

Interest in women's sexual functioning has increased in recent years although the primary emphasis has been on deficits in both genital and subjective sexual response. Female sexual psychophysiology research suggests that women are capable of greater sexual responsiveness than previously thought and can experience genital response in the absence of a subjective experience of sexual arousal. Women who report relatively persistent genital arousal, both with and without accompanying distress, provide case examples of the potential for dissociation between genital and psychological sexual response. In this article, we provide case illustrations of women reporting unprovoked genital arousal both with and without distress and suggest that what appears to be spontaneous genital arousal in some women may be the result of either subconscious processing of sexual stimuli in the environment—stimuli that are either consciously unacceptable or not noticed. Finally, we suggest that there may exist three types of genital arousal in women: 1) spontaneous sensations of genital arousal that are appraised as mildly pleasurable; 2) persistent feelings of genital arousal that are experienced as mildly distracting but not especially unwelcome or bothersome; and 3) continuous, intense, and persistent genital arousal that is extremely distracting, distressing, and worrisome. A variety of psychological, pharmacological, vascular, and neurological factors may account for these differences in women's genital arousal responsiveness. However, a full understanding of the range and variation in women's sexual experience remains to be elucidated.
Three-Dimensional Rotations of the Scapula During Arm Abduction: Evaluation of the Acromion Marker Cluster Method in Comparison With a Model-Based Approach Using Biplanar Radiograph Images.

Noninvasive methods enabling measurement of shoulder bone positions are paramount in clinical and ergonomics applications. In this study, the acromion marker cluster (AMC) method is assessed in comparison with a model-based approach allowing scapula tracking from low-dose biplanar radiograph images. Six healthy male subjects participated in this study. Data acquisition was performed for 6 arm abduction positions (0°, 45°, 90°, 120°, 150°, 180°). Scapula rotations were calculated using the coordinate systems and angle sequence was defined by the ISB. The comparison analysis was based on root mean square error (RMSE) calculation and nonparametric statistical tests. RMSE remained under 8° for 0° to 90° arm abduction and under 13.5° for 0° to 180° abduction; no significant differences were found between the 2 methods. Compared with previous works, an improved accuracy of the AMC approach at high arm abduction positions was obtained. This could be explained by the different sources of data used as the "gold standard. "
Visualization of Actin Fibers Associated with the Cell Membrane in Amoebae of Dictyostelium discoideum * ( microfilaments / myosin / tubulin

Amoebae of Dictyostelium discoideum were attached to a surface coated with polylysine, and the upper portion of the cells was sheared off with a stream of buffer. Scanning and transmission electron microscopy showed that the cytoplasmic surface of the exposed membrane was covered with fibers consisting of actin-containing filaments. The actin was identified by its solubility properties and its ability to interact with muscle myosin. In preceding work (1-3) proteins from amoebae of Dictyostelium discoideum that closely resemble the muscle proteins actin and myosin were l)urified and characterized, and it was shown biochemically that some of the Dictyostelium actin is associated with the cell membrane (2). In the present study, membrane-associated actin filaments were visualized by electron microscopy, utilizing a new technique in which cells were attached to surfaces coated with polylysine, and then disrupted to expose the cytoplasmic face of the cell membrane. The use of polylysine as an adhesive for electron microscopy was recently described by Mazia and coworkers (4); protamille sulfate was similarly employed by Vacquier (5) in his examination of the inner membrane surfaces in sea urchin eggs. MATERIALS AND METHODS Buffers and Reagents. The phosphate buffer (Buffer P) used to resuspend D. discoideurn cells contained 20 mM potassium phosphate, pH 6.4, 20 mM KCl, 5 mM MgCl2, and 0.5 mg/ml of streptomycin sulfate (6). The buffer used for cell disrultion (Buffer D) contained 10 mM Tris-HCl, pH 7.5, 0.1 M KCl, and 1 mM MgCl2. Poly(Llysine) (molecular weight 80,000100,000) was obtained from New England Nuclear, Boston. Growth and Preparation of Cells. D. discoideurn, strain NC-4, was a gift of Dr. W. F. Loomis, Jr. Cells were grown on SMI nutrient agar plates (6) in conjunction with Klebsiella aerogenes. Spores from a single sorus were spread with 0.2 ml of an overnight culture of bacteria and allowed to grow at room temperature (230). After approximately 40 hr, clearing of the bacterial lawn occurred. Cells were rinsed from clear areas of the plate with Buffer P and separated from bacteria by lowspeed centrifugation. The pellet of amoebae was resuspended in the same buffer at a density of 107 to 108 cells per ml. A drop Abbreviation: SI, subfragment 1 (product of limited papain diges-
L-Asparaginase-Induced Reversible Posterior Leukoencephalopathy Syndrome in a Child with Acute Lymphoblastic Leukemia

Reversible posterior leukoencephalopathy syndrome (RPLS) is being increasingly described with various etiologies even in the absence of hypertension. We present an 11-year-old patient with acute lymphoblastic leukemia who presented with seizures while on treatment with L-asparaginase. MRI showed bilaterally symmetrical nonenhancing occipital lesions characteristic of RPLS. L-Asparaginase-induced RPLS is a rare cause of neurological symptoms in patients on induction chemotherapy.
Type Iv Hypersensitivity Reaction to a Temporary Tattoo

A 6-year-old boy developed a skin eruption 10 days after application of a temporary tattoo advertised as a “natural black henna tattoo. ” The eruption was a delayed hypersensitivity reaction to the tattoo ink. The textile dye paraphenylenediamine (PPD) is a common industrial allergen and can be found in some temporary tattoo inks. This case describes the reaction and reviews the international literature pertaining to PPD and temporary tattoos.
Impact of hypoxia induced VEGF and its signaling during caudal fin regeneration in Zebrafish

Hypoxia is known to play important role during various cellular process, including regeneration. Regeneration is a complex process involving wound healing and tissue repair. We propose that hypoxia might mediate regeneration through angiogenesis involving angiogenic factors such as VEGF, VEGF-R2, NRP1a during the wound healing process. We have chosen Zebrafish model to study the role of hypoxia induced regeneration. Unlike mammals Zebrafish has the ability to regenerate. Hypoxic condition was mimicked using inorganic salt cobalt chloride to study caudal fin regeneration in adult Zebrafish. Intense blood vessel formation, with increased tail fin length experimented at various time points have been observed when adult zebrafish caudal fin partially amputated were exposed to 1% CoCl2. Regeneration is enhanced under hypoxia, with increased VEGF expression. To study the significance of VEGF signaling during wound healing and tissue regeneration, sunitinib well known inhibitor of VEGF receptor is used against CoCl2-induced caudal fin regeneration. Diminished fin length, lowering of blood vessel formation was documented using angioquant software, reduction in mRNA level of hypoxia inducible factors, VEGF and other pro-angiogenic genes such as VEGF,VEGF-R2, NRP1A, FGFR2, ANGPT1 were observed, while reduction in VEGF protein was demonstrated using western blot analysis. Genistein inhibitor of HIF-1α completely arrested regeneration, with suppression of VEGF highlighting the significance of hypoxia induced VEGF signaling during fin regeneration. Our results suggest that hypoxia through HIF-1α might lead to angiogenesis involving VEGF signaling during wound healing and this might throw light on therapeutic efficacy of cobalt chloride during regeneration.
A Hybrid Clustering Algorithm: The FastDBSCAN

Clustering is one of the most important tasks in knowledge discovery from data. The goal of clustering is to discover the nature structure of data or detect meaningful groups from data. The density-based clustering, such as DBSCAN, is a fundamental technique with many advantages in applications. However, DBSCAN algorithm has the quadratic time complexity, making it difficulty in real application with large data set. This paper presents a method to decrease the time complexity based on K-Means algorithm. Our algorithm divides the data in k partitions at first step and then uses a Min-Max method to select points for DBSCAN clustering at second step. Experiments show that our method obtains competitive results with the original DBSCAN, while significantly improving the computational time.
Inhibition of Epstein-Barr Virus OriP Function by Tankyrase, a Telomere-Associated Poly-ADP Ribose Polymerase That Binds and Modifies EBNA1

ABSTRACT Tankyrase (TNKS) is a telomere-associated poly-ADP ribose polymerase (PARP) that has been implicated along with several telomere repeat binding factors in the regulation of Epstein-Barr virus origin of plasmid replication (OriP). We now show that TNKS1 can bind to the family of repeats (FR) and dyad symmetry regions of OriP by using a chromatin immunoprecipitation assay and DNA affinity purification. TNKS1 and TNKS2 bound to EBNA1 in coimmunoprecipitation experiments with transfected cell lysates and with purified recombinant proteins in vitro. Two RXXPDG-like TNKS-interacting motifs in the EBNA1 amino-terminal domain mediated binding with the ankyrin repeat domain of TNKS. Mutations of both motifs at EBNA1 G81 and G425 abrogated TNKS binding and enhanced EBNA1-dependent replication of OriP. Small hairpin RNA targeted knock-down of TNKS1 enhanced OriP-dependent DNA replication. Overexpression of TNKS1 or TNKS2 inhibited OriP-dependent DNA replication, while a PARP-inactive form of TNKS2 (M1045V) was compromised for this inhibition. We show that EBNA1 is subject to PAR modification in vivo and to TNKS1-mediated PAR modification in vitro. These results indicate that TNKS proteins can interact directly with the EBNA1 protein, associate with the FR region of OriP in vivo, and inhibit OriP replication in a PARP-dependent manner.
Ambiguity function used for detection of confocal microscope

In the conventional confocal microscope, the alignment of physical pinholes is an important problem. In this paper, a digital pinhole filter based on image restoration is investigated for the confocal microscope. Firstly, we discuss the properties of ambiguity function. Next, we use it to build the off-focus point spread function (PSF). Then, we use image restoration technique based on inverse filtering method to reject out-of-focus light in order to improve the depth resolution. Experimental results indicate that the method can reduce the pixel crosstalk resulting from out-of-focus light, and the alignment of pinholes can be made easy.
Feedback Analysis of Radial Basis Functions Neural Networks via Small Gain Theorem

Abstract Radial basis function neural networks are used in a variety of applications such as pattern recognition, nonlinear identification, control, time series prediction, etc. In this paper, feedback analysis of the learning algorithm of radial basis function neural networks is presented. It studies the robustness of the learning algorithm in the presence of uncertainties that might be due to noisy perturbations at the input or to modeling mismatch. The learning scheme is first associated with a feedback structure and then the stability of that feedback structure is analyzed via small gain theorem. The analysis suggests bounds on the learning rate in order to guarantee that the learning algorithm will behave as robust nonlinear filters and optimal choices for faster convergence speeds.
Term-Mouse-Fixations as an Additional Indicator for Topical User Interests in Domain-Specific Search

Models in Interactive Information Retrieval (IIR) are grounded very much on the user's task in order to give system support based on different task types and topics. However, the automatic recognition of user interests from log data in search systems is not trivial. Search queries entered by users a surely one such source. However, queries may be short, or users are only browsing. In this paper, we propose a method of term-mouse-fixations which takes the fixations on terms users are hovering over with the mouse into consideration to estimate topical user interests. We analyzed 22,259 search sessions of a domain-specific digital library over a period of about four months. We compared these mouse fixations to user-entered search terms and to titles and keywords from documents the user showed an interest in. These terms were found in 87.12% of all analyzed sessions; in this subset of sessions, per session on average 11.46 term-mouse-fixations from queries and viewed documents were found. These terms were fixated significantly longer with about 7 seconds than other terms with about 4.4 seconds. This means, term-mouse-fixations provide indicators for topical user interests and it is possible to extract them based on fixation time.
Alpha 1 Acid Glycoprotein: Increased Serum and Localized mRNA Expression as a Monitor for Reactions in Leprosy

Alpha 1 Acid Glycoprotein (AGP) has been identified as a potentially useful marker of clinical outcome in disease having an inflammatory component. The objective of this study is to determine the levels of AGP with the possibility of using as a biomarker for Type 1 reactions (T1R) and Type 2 reactions (T2R) in leprosy. Serum levels of AGP are evaluated in a total of 88 leprosy subjects [T1R; n = 32, T2R; n =17 and Non-Reactional (NR); n = 39] using an Enzyme Linked Immunosorbent Assay (ELISA). Relative quantification of mRNA encoding AGP is also done from skin biopsies of same patients using Real-time PCR. The results revealed that the levels of serum AGP are significantly higher in all leprosy cases with T1R and T2R when compared to NR leprosy cases across the study groups (p < 0.05). The Cross-sectional analysis also revealed that the levels of mRNA expression of AGP are significantly higher (p < 0.05) in leprosy cases with both reactions when compared to non-reactional leprosy Cases (p < 0.05). Comparisons are made using Kruskal-Wallis nonparametric test. Significantly higher levels of AGP in serum and in the lesions of patients may indicate its role as a predictive biomarker for type 1 and 2 reactions in leprosy.
Land Market Interactions between Heterogeneous Agents in a Heterogeneous Landscape—Tracing the Macro‐Scale Effects of Individual Trade‐Offs between Environmental Amenities and Disamenities

Heterogeneity in both the spatial environment and economic agents is a crucial driver of land market dynamics. We present an agent-based land market model where land from agriculture use is transferred into urban. The model combines the microeconomic demand, supply, and bidding foundations of spatial economics models with the spatial heterogeneity of spatial econometric models in a single methodological platform. Heterogeneous agents exchange heterogeneous spatial goods via simulated bilateral market interactions. We model a coastal city where both coastal amenities and flooding or erosion disamenities drive land market outcomes, facilitating separate analysis of the effects of each driver on land rents and land development patterns. We also analyze the implications of homogeneous versus heterogeneous but unbiased flood risk perceptions. Since buyers with low risk perceptions drive market outcomes, spatial development under heterogeneous risk perceptions differs qualitatively, with more expansion into risky areas. Our results highlight the shortcomings of policy models based on representative agent assumptions and the importance of including agent-level data in empirical modeling.
Cubic–tetragonal transition in KMnF3: IR hard-mode spectroscopy and the temperature evolution of the (precursor) order parameter

Precursor effects were observed in KMnF3 using infrared hard-mode spectroscopy. The intensity of the infrared-active mode near 265 cm−1 follows the thermodynamic order parameter, Q, in the tetragonal phase (I4/mcm). An additional weak signal is found in the cubic phase (). The order parameter step at To = 185.95 K (L = 0.129 J g−1) is smeared with excess intensity due to the tetragonal short range order extending to T>215 K. The intensity follows the predictions of Landau theory with a defect field Gdefect = −hQ, h = 6 J mol−1. The observed excess intensities are compared with the appearance of precursor elastic softening. It is concluded that the precursor softening and the local tetragonal short range order are likely to be related to an extended defect structure, such as a tweed pattern, which may be stabilized by extrinsic defects.
Registered report: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The papers, which were published between 2010 and 2012, were selected on the basis of citations and Altmetric scores (Errington et al., 2014). This Registered Report describes the proposed replication plan of key experiments from “Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET” by Peinado and colleagues, published in Nature Medicine in 2012 (Peinado et al., 2012). The key experiments being replicated are from Figures 4E, as well as Supplementary Figures 1C and 5A. In these experiments, Peinado and colleagues show tumor exosomes enhance metastasis to bones and lungs, which is diminished by reducing Met expression in exosomes (Peinado et al., 2012). The Reproducibility Project: Cancer Biology is a collaboration between the Center for Open Science and Science Exchange and the results of the replications will be published in eLife. DOI: http://dx.doi. org/10.7554/eLife.07383. 001
Coincidence of some classes of universal functions

Let Ω a domain in the complex plane such that Ω satisfies appropriate geometrical and topological properties. We prove that if f is a holomorphic function in Ω, then its Taylor series, with center at any ξ Є Ω , is universal with respect to overconvergence if and only if its Cesaro (C, k)-means are universal for any real k > −1. This is an extension of the same result, proved recently by F. Bayart, for any integer k ≥ 0. As a consequence, several classes of universal functions introduced in the related literature are shown to coincide.
Analysis-Synthesis Dictionary Learning for Universality-Particularity Representation Based Classification

Dictionary learning has played an important role in the success of sparse representation. Although synthesis dictionary learning for sparse representation has been well studied for universality representation (i.e., the dictionary is universal to all classes) and particularity representation (i.e., the dictionary is class-particular), jointly learning an analysis dictionary and a synthesis dictionary is still in its infant stage. Universality-particularity representation can well match the intrinsic characteristics of data (i.e., different classes share commonality and distinctness), while analysis-synthesis dictionary can give a more complete view of data representation (i.e., analysis dictionary is a dual-viewpoint of synthesis dictionary). In this paper, we proposed a novel model of analysis-synthesis dictionary learning for universality-particularity (ASDL-UP) representation based classification. The discrimination of universality and particularity representation is jointly exploited by simultaneously learning a pair of analysis dictionary and synthesis dictionary. More specifically, we impose a label preserving term to analysis coding coefficients for universality representation. Fisher-like regularizations for analysis coding coefficients and the subsequent synthesis representation are introduced to particularity representation. Compared with other state-of-the-art dictionary learning methods, ASDL-UP has shown better or competitive performance in various classification tasks.
Response to neoadjuvant systemic therapy for breast cancer in BRCA mutation carriers and noncarriers: a single-institution experience.

PURPOSE To compare the pathologic complete response (pCR) rate and relapse-free survival (RFS) and overall survival (OS) after neoadjuvant systemic chemotherapy (NST) in patients with breast cancer with and without deleterious BRCA1 and BRCA2 mutations. PATIENTS AND METHODS A total of 317 women who underwent BRCA genetic testing and were treated with NST for breast cancer between 1997 and 2009 were included in the study. The Kaplan-Meier product-limit method was used to estimate RFS and OS rates. Logistic regression models were fit to determine the associations between BRCA status, pCR, and survival. RESULTS Fifty-seven (18%) and 23 (7%) patients had BRCA1 and BRCA2 mutations, respectively. Twenty-six (46%) of 57 BRCA1 carriers achieved a pCR, compared with three (13%) of 23 BRCA2 carriers and 53 (22%) of 237 BRCA noncarriers (P < .001). In the multivariate logistic model, BRCA1 status (odds ratio [OR] = 3.16; 95% CI, 1.55 to 6.42; P = .002), estrogen receptor (ER) negativity (OR = 1.96; 95% CI:1.05 to 3.65; P = .03) and concurrent trastuzumab use (OR = 4.18; 95% CI, 2.04 to 8.57; P < .001) remained as independent significant predictors for a pCR. At a median follow-up of 3.2 years, 69 patients (22%) experienced a disease recurrence or death. No significant differences were noted in survival outcomes with respect to BRCA status and type of NST received. However, among BRCA1 carriers, patients who achieved a pCR had better 5-year RFS (P = .001) and OS (P = .01) rates than patients who did not. CONCLUSION BRCA1 status and ER negativity are independently associated with higher pCR rates in patients with breast cancer. Overall prognosis of breast cancer in BRCA carriers is similar to sporadic breast cancers.
Development and Test of an NbTi/YBCO Composite Magnet

In order to extend the basic research on the stability of composite conductors combined with low-temperature superconductors and high-temperature superconductors and to explore its applications, an NbTi/YBCO composite magnet was developed and tested in this paper. A special combination method and a special transposition method were applied during the winding process to balance the current and the magnetic field between the two superconductors. The minimum quench energy of the NbTi/YBCO composite magnet and an NbTi magnet were measured.