Miracle-dz/UniFAR-FTUs huggingface dataset:
The Health Diary Telemonitoring and Hospital-Based Home Care Improve Quality of Life Among Elderly Multimorbid COPD and Chronic Heart Failure Subjects

Background: Elderly, multimorbid patients with advanced chronic obstructive pulmonary disease (COPD) and/or chronic heart failure (CHF) exhibit poor health-related quality of life (HRQoL). Telemonitoring, based on digital pen technology, supported by hospital-based home care (HBHC) signi ﬁ cantly reduces the number of hospitalizations. We hypothesized that the same intervention would prevent the deterioration of HRQoL that follows upon disease progression. Methods: Elderly computer-illiterate subjects with ≥ 2 hospitalizations the previous year were included. HRQoL was assessed at inclusion (baseline) and at 1, 6 and 12 months employing EuroQol-5 Dimensions (EQ-5D) and RAND-36 for general HRQoL, and Minnesota Living with Heart Failure Questionnaire (MLHFQ) and St. Georges Respiratory Questionnaire (SGRQ) for disease-speci ﬁ c HRQoL. Healthcare contacts, hospitalizations, as-needed medications, prescription changes and healthcare costs were registered. Results: Ninety-four patients were enrolled of which 53 subjects completed the 12-month study period. Compared to baseline, most domains of RAND-36 were improved signi ﬁ cantly at 1 time-point or more. Only among COPD subjects, the disease-speci ﬁ c HRQoL was worsened at the 12 month evaluation. Measures of healthcare dependency were associated with poor HRQoL. Conclusion: The Health Diary system and HBHC together improve general HRQoL, and measures of healthcare dependency are associated with HRQoL variables. t -test. Abbreviations: chronic heart failure; COPD, chronic obstructive pulmonary disease, HBHC, specialized hospital-based home care; P.R. N. , as-needed; N.s. ,
INVESTIGATION FOR POWER OVER FIBER IMPACT ON GIGABIT DATA TRANSMISSION IN SI-POF

: We present experimental and theoretical results on the influence of the power-over-fiber signal (PoF) on the data traffic signal-to-noise ratio when transmitted simultaneously into SI-POF. We also discuss the potential of PoF to optically powering multiple sensors in specific applications like IoT. (PV) different powering our PoF The the P
RUNNING HEAD: Diet in childhood defines testes’ lipid content in adulthood

36 Childhood obesity is a serious concern associated with ill health later in life. 37 Emerging data suggest that obesity has long-term adverse effects upon male 38 sexual and reproductive health but few studies addressed this issue. We 39 hypothesized that exposure to high-fat diet during early life alters testicular lipid 40 content and metabolism leading to permanent damage to sperm parameters. 41 After weaning (day 21 after birth), 36 male mice were randomly divided into 3 42 groups and fed with different diet regimen for 200 days: CTRL–standard chow; 43 HFD–high-fat diet (Carbohydrate: 35.7%, Protein: 20.5%, Fat: 36.0%); HFDt– 44 high-fat diet for 60 days then replaced by standard chow. Biometric and 45 metabolic data were monitored. Animals were then sacrificed, and tissues 46 collected. Epididymal sperm parameters and endocrine parameters were 47 evaluated. Testicular metabolites were extracted and characterized by 1H-NMR 48 and GC-MS. Testicular mitochondrial and antioxidant activity were evaluated. 49 Our results show that mice fed with high-fat diet, even if only until early 50 adulthood, had lower sperm viability and motility, and higher incidence of head 51 and tail defects. Although diet reversion with weight loss during adulthood 52 prevents the progression of metabolic syndrome, testicular content in fatty acids 53 is irreversibly affected. Excessive fat intake promoted an over-accumulation of 54 pro-inflammatory n-6 polyunsaturated fatty acids in testis, which are strongly 55 correlated with negative effects upon sperm quality. Therefore, the adoption of 56 high-fat diets during early life correlates to irreversible changes in testicular lipid 57 content and metabolism, which are related to permanent damage to sperm 58 quality later in life. 59
Fabrication of a Novel Culture Dish Adapter with a Small Recess Structure for Flow Control in a Closed Environment

Cell culture medium replacement is necessary to replenish nutrients and remove waste products, and perfusion and batch media exchange methods are available. The former can establish an environment similar to that in vivo, and microfluidic devices are frequently used. However, these methods are hampered by incompatibility with commercially available circular culture dishes and the difficulty in controlling liquid flow. Here, we fabricated a culture dish adapter using polydimethylsiloxane that has a small recess structure for flow control compatible with commercially available culture dishes. We designed U-shaped and I-shaped recess structure adapters and we examined the effects of groove structure on medium flow using simulation. We found that the U-shaped and I-shaped structures allowed a uniform and uneven flow of medium, respectively. We then applied these adaptors to 293T cell culture and examined the effects of recess structures on cell proliferation. As expected, cell proliferation was similar in each area of a dish in the U-shaped structure adapter, whereas in the early flow area in the I-shaped structure adapter, it was significantly higher. In summary, we succeeded in controlling liquid flow in culture dishes with the fabricated adapter, as well as in applying the modulation of culture medium flow to control cell culture.
The plant defense elicitor cryptogein stimulates clathrin-mediated endocytosis correlated with ROS production in BY-2 tobacco cells

plant defense elicitor cryptogein triggers well-known biochemical events of early signal transduction at the plasma membrane of tobacco cells, observations of cell responses related to these early events were lacking. We determined that internalization of the lipophilic dye FM4-64, which is a marker of endocytosis, is stimulated a few min after addition of cryptogein to tobacco BY-2 cells. This stimulation is specific to the signal transduction pathway elicited by cryptogein since a lipid transfer protein, which binds to the same receptor as cryptogein but without triggering signaling, does not increase endocytosis. of ROS production occurring first after elicitation. cells when indicate early endocytic process induced by cryptogein in tobacco is at least partly, to clathrin-mediated endocytosis and is dependent on ROS production by the NADPH oxidase NtrbohD. the number of pits pinched off from the plasma membrane of 30-40 cells in ultra-thin sections for each condition. In cryptogein-elicited cells, we observed a significant transitory CCP increase in the first 10 min which may correspond to activation of the endocytosis machinery during this time-lapse. As we did consider the internalized clathrin-coated vesicles (CCV) which may no longer be coated within the cytosol (Holstein, 2002), the results, corresponding to appearance of CCPs at the plasma membrane are not directly comparable with FM4-64 experiments in which all fluorescent vesicles were counted. However, both indicate a very early stimulation of endocytosis upon elicitor treatment. Moreover, these results can be related to the work of Fomina et al. who used FM1-43 dye to show an accelerated endocytosis in phytohemagglutinin-activated pre-designated provide a for rapid multiple production of vesicles. that plant cell endocytosis, in only a mechanism for receptor down-regulation also a for signaling As and
The Use of Data Cleansing in Mobile Devices

—People receive information on PDA, mobile phone or mp3 player. If such information was correct, current, useful and usable, users would be able to use it immediately from any mobile device with no requirement of a personal computer to assess, clean and integrate data. The present research proposes the utilization of a data cleansing framework for the improvement of data quality in mobile devices.
EPIC 211391664 B: A 32-M⊕ NEPTUNE-SIZED PLANET IN A 10-DAY ORBIT TRANSITING AN F8 STAR

We report the discovery of EPIC 211391664b, a transiting Neptune-sized planet monitored by the K2 mission during its campaign 5. We combine the K2 time-series data with ground-based photometric and spectroscopic follow-up observations to confirm the planetary nature of the object and derive its mass, radius, and orbital parameters. EPIC 211391664b is a warm Neptune-like planet in a 10-day orbit around a V=12.2 mag F-type star with M? =1.074 ± 0.042 M , R? =1.311 −0.048 R , and age of 5.2 −1.0 Gyr. We derive a planetary mass and radius of Mp= 32.2 ± 8.1 M⊕ and Rp=4.3 +0.3 −0.2 R⊕. EPIC 211391664 b joins the relatively small group of Neptune-sized planets whose mass and radius have been derived with a precision better than 3-σ. We estimate that the planet will be engulfed by EPIC 211391664 in ∼3 Gyr, due to the evolution of the host star towards the red giant branch.
A COMPACT DUAL BAND-NOTCHED MIMO DIVERSITY ANTENNA FOR UWB WIRELESS APPLICATIONS

In this paper, a compact ultra-wideband (UWB) multiple-input multiple-output (MIMO) spatial diversity antenna with dual band-notches designed on an FR4 substrate is proposed and experimentally investigated. The antenna consists of two radiating elements fed by two tapered microstrip lines. Two inverted L-shaped slits are used to introduce notches at WLAN (5.15–5.85 GHz) and IEEE INSAT/Super-Extended C-band (6.7–7.1 GHz). An isolation of more than 15 dB is achieved through the whole working band (2.9–10.8 GHz) by introducing a T-shaped decoupling structure on the ground plane. Furthermore, the envelope correlation coefficient (ECC), diversity gain (DG), multiplexing efficiency, TARC, peak gain and radiation patterns of the MIMO antenna are also discussed. The simulated and measured results show that the proposed UWB MIMO antenna is a good candidate for UWB diversity applications.
PHYTOCHEMICAL AND ANTIMICROBIAL EVALUATION OF THE LEAVES OF ANTIARIS TOXICARIA, (LESCH)

: Antiaris toxicaria Lesch. commonly known as bark cloth tree. Its medicinal value is yet unexplored, hence this study forms a basis for the active components present in it and further isolation of the compound. The preliminary phytochemical screening in different solvent extracts of Antiaris toxicaria leaves, collected in the area Anaikatti, Coimbatore District exhibited variations in the presence of phytocompounds depends upon the polarity of solvents, the methanolic extract showed the presence of all phytoconstituents except alkaloids. In the present study, the methanol extract showed good antibacterial activity than chloroform and water extracts. It revealed that the methanol was the most effective solvent for the antibacterial activity. In antifungal activity, the aqueous and methanol extract showed good activity against Cuvularia lunata and Aspergillus flavus in which the zone of inhibition was higher against Aspergillus flavus.
DELETION OF GSTT1 GENE POLYMORPHISM AS A RISK FACTOR FOR DEVELOPMENT OF CHRONIC MYELOID LEUKEMIA

Background: Chronic myeloid leukemia (CML), as most of cancers results from complex interaction between genetic or non genetic factors. Exposures to xenobiotics endogenous or exogenous associated with a reduced individual ability in detoxifying activity, constitutes a risk of developing cancer. It is known that polymorphism of glutathione S-transferases (GSTs) genes affects the detoxification of xenobiotics. Materials and Methods: Thus, we conducted a case-control study in which 50 patients (Mean age ± SD, 45.0 ± 12.9 years) with CML and 93 healthy unrelated controls (Mean age ± SD, 38.2 ± 10.3 years) have participated. GSTT1 genotypes were determined by polymerase chain reaction. Logistic regression was used to assess the possible link between GSTT1 null genotypes and CML as well as between combined genotypes and CML. Results: GSTT1 null genotype frequency was slightly higher in patients than control (50.0% vs. 16.7%) but, it was not associated with CML (OR 95% CI, 1.4, 0.78-2.48; p = 0.271). Surprisingly, GSTT1 null genotype was significantly associated with the risk of CML in males (OR 95% CI, 5, 1.25-20.1; p = 0.023). In summary our findings have shown that GSTT1 null genotype might be a risk factor of CML. However, further studies with a large sample size are needed to confirm our findings.
Grief and Trauma Reactions after Losing one’s Child The Efficacy of Support Groups for Parents Bereaved due to Illness or Accident

4 Introduction 5 ● Bereavement and Trauma 5 ● Mode of death 7 ● Loss of a child 8 ● Bereavement interventions 12 ● Support groups for bereaved parents 12 ● Current study 14 Method 15 ● Respondents 15 ● Procedure 17 ● Measures 18 ● Analyses 19 Results 20 ● CG and PTSD symptoms following loss of a child 20 ● Efficacy of support groups for bereaved parents 21 Discussion 23 ● CG and PTSD symptoms following loss of a child 23 ● Efficacy of support groups for bereaved parents 25 ● Limitations 26 ● Suggestions for future studies 28
Efficiency of Effective Microorganisms (EM) to Induce Resistance against Chocolate Spot Disease and Enhance Productivity of Faba Bean under Reclaimed Soil Conditions

eries of experiments including in vivo , greenhouse and field trials were conducted Egypt during two successive winter seasons (2009/10 and 2010/11) to investigate the effect of foliar application with some biotic formulas based on effective microorganisms (EM) as resistance inducers for faba bean ( Vicia faba L.) growth, total pigments and chlorophyll, yield as well as chocolate spot disease resistance cause by Botrytis fabae . Onion, garlic or cabbage were used to formulate these biotic formulas in EM1 or EM5. Application of these biotic formulas at the concentrations of 4% and 8% significantly suppressed the disease severity and increased total pigments, chlorophyll and phenols contents, enzymes activity and, therefore, plant growth and productivity. Results indicated that when the infection of chocolate spot disease, caused by Botrytis fabae, exists as a serious common biotic stress, the usage of the biotic formulas as inducers is essential as clean development mechanism (CDM) concept to satisfy the needs of the clean agriculture. When the infection alert is existing at the vegetative stage; the foliar application either with (EM5+garlic) 4%, (EM5+onion) 8% or (EM5+onion 4%), respectively, once at 30 days after sowing date is highly recommended. In case of the alert is postponed until the flowering or reproductive stage, foliar application with (EM5+garlic) 8% once at 60 days after sowing date is precisely a must.
OPTIMIZATION OF INVENTORY SYSTEM IN TWO-ECHELON WITH TWO SUPPLIERS

: This paper presents a continuous review two echelon inventory system. The operating policy at the lower echelon is (s, S) that is whenever the inventory level traps to s on order for Q = (S-s) items is placed, the ordered items are received after a random time which is distributed as exponential. We assume that the demands accruing during the stock-out period are lost. The retailer replenishes their stock from the regular supplier which adopts (0, M) policy, M = nQ. When the regular supplier stock is empty the replacement of retailer stock made by the outside supplier who adopts (0, N) policy N = nQ. The joint probability disruption of the inventory levels of retailer, regular supplier and the outside supplier are obtained in the steady state case. Various system performance measures are derived and the long run total expected inventory cost rate is calculated. Several instances of numerical examples, which provide insight into the behavior of the system are presented.
Journal of Physical Education, Sport, Health and Recreations Basic Motor Ability: Aquatic Learning for Early Childhood

This study aimed to determine the impacts of aquatic learning on the basic motoric abilities of early childhood. Experimental research of one group pretest-posttest design was applied in this study. This study involved eight kindergarten students: aged 5-6 years. This study was conducted twice a week for 4 weeks; 60 minutes per meeting. The instruments were structured observation, field notes, and documenta-tion of the child’s basic motor consisting of 9 aspects, namely water orientation, water entry, breath control, body position, buoyancy, arm propulsion, arm recovery, leg action, and combined movement. The data analysis technique used was paired sample t-test. The results showed an increase in basic motor skills of early childhood with P <0.05. From 9 aspects of assessment, the aspect of arm propulsion got the highest increase of 31.25% while the water orientation aspect got the lowest increase of 16.7%. The highest achievement of all aspects is achieved in the aspect of water orientation, which indicates that all children can do it well. Therefore, there was a positive influence of the provision of aquatic learning on improving basic motor skills for early childhood.
Recurrent fall in Parkinson Disease: Possible Role of the Proprioceptive and Vestibular Systems

Falls are a major risk for Parkinson disease patients (PD). We sought to understand why some patients fall once and some more than once (recurrent fallers). Recurrent fallers had PD significantly longer, 12.6 + 7.0 versus 5.9 + 4.5 years, had significantly higher motor MDS UPDRS scores” 31.2 + 12.7 versus 19.7 + 8.3, and walked with significantly shorter steps: 0.37 + 0.18 meters versus 0.52 + 0.19 meters than single fallers. The major difference between single fallers and recurrent fallers was an inability of recurrent fallers to stand on one leg for < 3 seconds: 95% versus 11 %, odds ratio 178 CI 95% 39.5-801.2 We attribute this inability to stand on one leg for < 3 seconds to an impairment of proprioceptive function and or possibly vestibular (utricle and sacculus) function. When a person stands on one leg, they effectively decrease their proprioceptive input by 50%. In two studies of tremor in PD we implicated proprioceptive and vestibular impairments. Such impairments were demonstrated more than 50 years ago by J Purdon Martin, the eminent English neurologist, in post-encephalitic Parkinson patients. Based on our studies of recurrent falls in PD we believe proprioceptive and vestibular impairments may be major risk factors in falls.
Information system supporting spatial decision-making and its quality

— Decision-making is an important part of human’s life. Information systems should highly support efficient decision making. Only well designed information systems with a high level of a quality can provide this kind of service. Approach to spatially-oriented information systems quality evaluation is described in the article. Next, a case study – evaluation of a quality of a Web-based intranet GIS application of a municipal authority, is described. In the end, obtained results and lessons learned from the evaluation are stated and commented.
University of Birmingham Spanning trees with few branch vertices

A branch vertex in a tree is a vertex of degree at least three. We prove that, for all s ≥ 1, every connected graph on n vertices with minimum degree at least ( 1 s +3 + o (1)) n contains a spanning tree having at most s branch vertices. Asymptotically, this is best possible and solves a problem of Flandrin, Kaiser, Ku˘zel, Li, and Ryj´a˘cek, which was originally motivated by an optimization problem in the design of optical networks.
Switching Behavior toward Online Shopping: Coercion or Choice during Covid-19 Pandemic

The pandemic, Covid-19, offered new opportunities for coercive online shopping to Indian consumers Non techno-savvy and less educated consumers have also switched to online shopping The present study investigates the customers' switching Behavior during the Covid-19 outbreak due to two attributes, perceived risks of infectious disease and the benefits of online shopping Purchase and consumption acted as moderators in the model A systematic empirical study with scientific research design was executed during March to August 2020 when the Covid-19 outbreak peaked, and online shopping became an alternate savior for continuity of life This was the period when sanitization and mask-wearing, social distancing, avoiding touch was made compulsory The hierarchical regression determined the catalyst role of Covid-19 in behavior switch and perception modification of online consumers Findings suggest the change in risk perception during the Covid-19 pandemic lead to a change in marketing policies focused on awareness building Control variables in the model behaved differently in online shopping, and new behaviors are expected to continue even after the pandemic This study will contribute to elucidate switching buying behavior and the growth of the online business
Developing a secure SQL/key-value translation service

As cloud services are becoming an alternative for IT infrastructures in many organizations, data privacy guarantees become a priority. This paper presents the development of a secure database system using Intel’s SGX trusted platform. SGX provides hardware-based processing privacy offering protection for a wide range of sophisticated attacks. We propose a modular, multi-service architecture that is well suited to the advantages and limitations of the SGX platform. This paper focuses on the ongoing implementation of our SQL translation service.
Ain't Nothing Like Family - Brown Bears Share their Home Range with Relatives

Sociality in animal populations is a continuum, and interactions between conspecifics are meaningful for all vertebrates. Ignorance of social structures can lead to misunderstanding their ecology and, consequently, to unsuccessful species management. Here, we combined genetic and spatial data on radio-collated brown bears (Ursus arctos) to investigate kin-related home range overlap and kin-related centroid distance within central and eastern Finland. We found that the extent of overlap of home ranges was positively linked with relatedness among adult females. A similar positive correlation could be detected between home range centroid distance and relatedness among adult females. Moreover, there were significant differences between the two studied regions: female brown bears in central Finland were more closely related to each other, and the sizes of their home ranges were larger than those in eastern Finland. The smaller home ranges and lower degree of relatedness among bears in eastern Finland might be a result of the substantially higher hunting pressure in the area, combined with immigration of new unrelated individuals from Russia.
Extraction of Top Backgrounds in the Higgs Boson Search with the $H\rightarrow WW^{\star}\rightarr

The search for a Standard Model Higgs boson with the $H\rightarrow WW^{\star}\rightarrow\ell\ell+\met$ decay and the application of a full-jet veto yields a strong sensitivity in the mass range $130<m_H<200\,\gev$. One of the residual backgrounds is related to processes involving top quarks. A method for the extraction of top backgrounds is evaluated at the parton and hadronic levels based on the data-driven extraction of the jet veto survival probability. The uncertainty of the proposed method is about 15%.