Miracle-dz/UniFAR-FTUs huggingface dataset:
Cytoprotective effect and clinical outcome of perioperative progesterone in brain tumors, a randomized microscopically evidence study

ABSTRACT Background and Aims Although progesterone role on TBI patients and its antitumor activity have been proved, its perioperative use in surgical brain tumors remains unclear. Primary outcome is to investigate any neuroprotective effects of perioperative intramuscular progesterone on the brain’s cellular inflammatory and neuro-excitotoxic response to tumor resection evidenced by neuronal cells immunohistochemistry and CT scanning. Secondary outcome is to explore the postoperative clinical course, any related complications, and post craniotomy short-term (3 months) outcome. Methods Two hundred fifty-two (252) adult patients, ASA class І-ІІ undergoing elective craniotomy were randomly allocated into two groups: progesterone (PR) and control (C) groups to receive either 1.0 mg/kg progesterone (diluted to a total volume of 2 ml) or 2 ml of isotonic saline daily intramuscular for five days before and after craniotomy. Results Histopathological biopsies revealed significant increase the expression of active nuclear PR receptors on oligodendrocytes and astrocytes (P-value = 0.0001), cytoplasmic and nuclear neuro-quiescence endorsed by keeping blood vessel integrity and preventing neutrophilic infiltration and cytoplasmic oedema (P-value = 0.005) in PR group. Follow up CT2 (on the morning of surgery) and CT3 (on the 3rd postoperative day) recorded a significant reduction of brain oedema (P = 0.0001&0.001). Also, significant earlier weaning with shorter ICU stay (P = 0.0001) and better postoperative 3 months outcome (P = 0.001) were demonstrated in progesterone group without any detectable complications. Conclusion Perioperative progesterone offered anti-neuroinflammatory and neuroprotective effect and reduced cytoplasmic brain oedema evidenced by histopathological biopsies and CT scanning. Also, it improved postoperative course and 3 months neurological outcome in surgical brain tumors.
Revisit Intention to Destination Image, eWOM, and Destination Personality: Kuta Beach Bali, Indonesia

Tourism in Bali is magnificent in the eyes of the international world. This beautiful island could attract millions of tourists both foreign and domestic. However, Bali recently has caught both national and international attention due to the huge amount of accumulation of marine litters that were frequently accumulated in the touristic area of the island especially in Kuta Beach Bali. Therefore, in this study, the author did research in regards to know what factors affect tourist’s intention to spend their time in Bali. The objectives of this research are (1) to analyze the influence of destination image towards tourists’ intention to revisit the destination (2) to analyze the influence of eWOM towards tourists’ intention to revisit the destination (3) to analyze the influence of destination personality towards tourists’ intention to revisit the destination. This type of research is quantitative ex post facto. The research sample was 129 tourists who had visited Kuta Beach Bali, Indonesia. Through the path analysis from PLS for version 3.0, it can be concluded that (1) the destination image has a positive and significant positive effect on revisit intention (2) eWOM has a positive and insignificant effect on revisit intention (3) the destination personality has a positive and significant effect on revisit intention. The implication of the results of the research are that efforts must be made to establish the destination reputation through overseeing the waste in tourist sites that could affect the destination itself.
Quenched and tempered high strength steel: A review

Quenched and tempered steel are broadly classified as low alloy conventional grades with C content of 0.15-0.40% and tool steels with C content as high as 2% alloyed with strong carbide forming elements such as Cr, V, Mo etc. in the range of 1-12%. In both the cases, steels are used in hardened/quenched and tempered or auto tempered condition for improved toughness, strength and wear resistance. The C content and tempering temperature are optimized based on desired application. However, achieving high strength/hardness along with adequate toughness is a challenge. The chemistry design is one of the important parts of developing these grades. The judicious amount of hardenability elements like Mn, Cr, Mo, B etc. are added for achieving required as quenched hardness while excess addition of these elements will not be cost effective. Optimized austenite grain size before quenching is also key to achieve hardenability as well as toughness. All these points have been reviewed systematically in this paper for the first time as there is no such review available covering all aspect of quenched and tempered grade. Unlike text books or any past review articles, this is a systematic review of quenched and tempered steel which will help in designing suitable chemistry and process parameters for producing different grades of quenched and tempered steel in industrial scale.
Can Voluntary Insurance Be a New Product in Bank-led e-banking

Purpose: In today’s modernized banking-services, customers compete for comparative time-saving-options and banking-service-providers compete for maximizing profits. In this win-win setup, many factors are unpredictable. These perceived risk (PR) factors have been undermining the vision of cashless-society country-wise such as Bangladesh. Banks can eliminate this issue by adopting Voluntary Insurance (VI) as a new product. But it raises question: how do customers feel about it? Methodology: This study uses a self-designed survey questionnaire, for conducting convenience sampling reliability analysis and tests the results using statistical analysis.Findings: Statistical analyses of customers’ preferences reveal that “age-group” and “occupation-group” of customers have different preferences. The result shows that demographic factors impact customers’ preferences for the new product.Practical Implications: The findings can attract more users by improving customer’s satisfaction, customer-base, banks benefits including reduction of operational-cost. Thus, the answer to the question posed in the title is: Yes. Thus, this effort brings the findings of the Survey-Opinions to the attentions of bank-leaderships and policymakers so that the VI becomes a product in bank-led e-banking services, which can be an example in economy country-wise.
Relationships between Instrumental and Sensory Quality Indices of Shine Muscat Grapes with Different Harvesting Times

The effects of instrumental quality indices on the sensory properties of Shine Muscat grapes harvested 16, 18, 20, and 22 weeks after full bloom (WAFB) were investigated. The berries harvested at 20 and 22 WAFB gained higher sweetness scores than those harvested at 16 and 18 WAFB, showing similar trends to that of total soluble solids (TSS) content. The sourness, astringency, and firmness scores were not significantly different among the samples. The flavor score showed a trend similar to that of sweetness perception. The higher flavor score in the berries harvested at 20 and 22 WAFB seemed to be derived from the development of floral aroma compounds, including linalool and its derivatives, with ripening. Consumer acceptance was highly correlated with sweetness and flavor perceptions. It was concluded that the TSS content and development of floral aroma compounds are the key quality parameters for Shine Muscat grapes, satisfying consumer acceptability in the market.
Current distribution on a cylindrical antenna with parallel orientation in a lossy magnetoplasma

The current distribution and impedance of a thin cylindrical antenna with parallel orientation to the static magnetic field of a lossy magnetoplasma is calculated with the method of moments. The electric field produced by an infinitesimal current source is first derived. Results are presented for a wide range of plasma parameters. Reasonable answers are obtained for all cases except for the overdense hyperbolic case. A discussion of the numerical stability is included which not only applies to this problem but other applications of the method of moments.
Prognostic Value of MUC16 Mutation and Its Correlation with Immunity in Hepatocellular Carcinoma Patients

Objective Identifying gene mutation signatures will enable a better understanding for the occurrence, development, and prognosis of hepatocellular carcinoma (HCC) and provide some potential biomarkers for clinical practice. This study investigated the mutated genes in HCC patients and assessed their relationship with tumor mutation burden (TMB) and prognosis. Methods The somatic mutation annotation format (MAF) document, mRNA expression matrix, and clinical information of HCC patients were obtained from the International Cancer Genome Consortium (ICGC) and the Cancer Genome Atlas (TCGA) database. The differences of TMB between the mutant type and the wild-type genes were detected using the Mann–Whitney U test. The link of gene mutations with prognosis was explored by the Kaplan–Meier analysis. The proportion of 22 immune cells' composition was measured using CIBERSORT algorithm. Results The two databases screened 16 common mutated genes, which included TP53, TTN, LRP1B, ZFHX4, MUC16, OBSCN, CSMD3, FLG, CSMD1, SYNE1, SPTA1, USH2A, KMT2C, PCLO, HMCN1, and FAT3. After a series of analysis, MUC16 mutation was found to be highly correlated with TMB and was regarded as an independent factor predicting HCC. Furthermore, gene set enrichment analysis (GSEA) indicated that the MUC16 mutation was significantly involved in HCC cell metabolism. Conclusions MUC16 mutation seems to be a valuable potential biomarker for HCC development and its overall survival.
Real-World Longitudinal Experience of Botulinum Toxin Therapy for Parkinson and Essential Tremor

Background: Botulinum toxin type A (BoNT-A) therapy for upper-limb tremor has emerged as a promising option. However, it is unclear in real-world practices whether a technology-guided approach can compare with expert clinical assessments (including surface anatomy and palpation) for improving outcomes. This retrospective study aims to review our clinical outcomes of treating essential tremor (ET) and Parkinson’s disease (PD) tremor using either clinical- or kinematic-based injection pattern determination methods. Methods: 68 ET and 45 PD patients received at least one injection for their upper-limb tremor (unilateral or bilateral) in the last 7 years. Demographics of patients and BoNT-A injections were collected. A Mann–Whitney U statistical test was used to compare outcome measures between ET and PD cohorts. Results: Mean age (72 ± 9 years), number of injections (5), years receiving therapy (~2 years), clinic- (~57%) or kinematic-based patterns, and self-paying (52%) were similar between both cohorts. BoNT-A as a monotherapy in both upper limbs was received in more ET than PD patients. Double reconstitution of Xeomin® in the wrist flexors/extensors, supinator, biceps, and triceps were most injected. Discontinuation due to no benefit/weakness was not dependent on the injection pattern determination approach. Conclusions: Kinematic-based BoNT-A injections produced similar treatment outcomes to injections based on the clinical expertise of the expert injector. This suggests that kinematics could be used by a non-expert to attain equivalent efficacy potentially improving access to this treatment.
Effect of taurine on histopathological features of spermatogenesis in seminiferous tubules of mice (Mus musculus) induced by paraquat

This study aimed to determine the effect of taurine on the enhancement of the spermatogenetic process in male mice (Mus musculus) induced by paraquat (PQ). Twenty-five male mice (Mus musculus) aged 2-3 months with a bodyweight of around 35 grams were divided randomly into five groups. The K + and the treatment group (P1, P2, and P3) mice were induced using PQ. PQ was given intraperitoneally (IP) twice a week for 21 consecutive days at a dose of 30 mg/kg BW. Two hours after the administration of PQ, P1, P2, and P3 groups were given taurine at a dose of 250, 500, and 1000 mg/kg BW/day for three weeks (Heidari et al., 2019). K- group was given distilled water (IP) only. On day-29, mice were sacrificed for testicles histopathological preparations with hematoxylin-eosin staining. Results showed that the mice exposed to PQ only (the K+ group) had a reduced spermatogenesis score compared to those of the K- group (p <0.05). Taurine treatment on PQ-exposed mice was followed by an increase spermatogenesis score. The optimal curative dose of taurine was 500 mg/kg (P2 group). However, a higher dose (1000 mg/kg BW) of taurine resulted in a decline in the spermatogenesis score than those of at the 500 mg/kg. It could be concluded that treatment with taurine could enhance the spermatogenetic process of male mice (Mus musculus) induced by PQ.
Exploration of the Virtual Reality Teleportation Methods Using Hand-Tracking, Eye-Tracking, and EEG

Abstract Although recent developments in VR tracking technology have enabled VR to become more portable and convenient, VR must overcome limited traversable space to be used for more general purposes. Since future VR HMDs aim to embed bio-sensors, such as eye-tracking and electroencephalography (EEG), the present study investigates how bio-sensors could be integrated into VR locomotion and how usability could be improved. In this paper, teleportation methods were developed by combining eye-tracking, EEG, and hand-tracking for location targeting and teleport triggering processes. In a static teleportation task, we compared the efficiency, accuracy, and usability of each method as well as the interactions between different combinations of methods. The experimental results verified that these locomotion methods were overall suitable for hands-free VR contents, and revealed relative superiority of eye-tracking for location targeting and hand-tracking for teleport triggering. Importantly, we identified specific combinations of locomotion methods appropriate for context by showing the interactions between experimental factors, and components that require improvement for future application. The results of this study contribute to development and understanding of novel VR locomotion methods utilizing bio-signal data, for more efficient and natural VR locomotion experience.
Antibiofilm Effect of Silver Nanoparticles in Changing the Biofilm-Related Gene Expression of Staphylococcus epidermidis

Nowadays, antibiotic resistance is a major public health problem. Among staphylococci, infections caused by Staphylococcus epidermidis (S. epidermidis) are frequent and difficult to eradicate. This is due to its ability to form biofilm. Among the antibiotic substances, nanosilver is of particular interest. Based on this information, we decided to investigate the effect of nanosilver on the viability, biofilm formation and gene expression of the icaADBC operon and the icaR gene for biofilm and non-biofilm S. epidermidis strains. As we observed, the viability of all the tested strains decreased with the use of nanosilver at a concentration of 5 µg/mL. The ability to form biofilm also decreased with the use of nanosilver at a concentration of 3 µg/mL. Genetic expression of the icaADBC operon and the icaR gene varied depending on the ability of the strain to form biofilm. Low concentrations of nanosilver may cause increased biofilm production, however no such effect was observed with high concentrations. This confirms that the use of nanoparticles at an appropriately high dose in any future therapy is of utmost importance. Data from our publication confirm the antibacterial and antibiotic properties of nanosilver. This effect was observed phenotypically and also by levels of gene expression.
Surface Structure Determination by LEED and X-rays

This timely text covers the theory and practice of surface and nanostructure determination by low-energy electron diffraction (LEED) and surface X-ray diffraction (SXRD): it is the first book on such quantitative structure analysis in over 30 years. It provides a detailed description of the theory, including cutting-edge developments and tested experimental methods. The focus is on quantitative techniques, while the qualitative interpretation of the LEED pattern without quantitative I(V) analysis is also included. Topics covered include the future study of nanoparticles, quasicrystals, thermal parameters, disorder and modulations of surfaces with LEED, with introductory sections enabling the non-specialist to follow all the concepts and applications discussed. With numerous colour figures throughout, this text is ideal for undergraduate and graduate students and researchers, whether experimentalists or theorists, in the fields of surface science, nanoscience and related technologies. It can serve as a textbook for graduate-level courses of one or two semesters.
Multi-Omic Analysis of Two Common P53 Mutations: Proteins Regulated by Mutated P53 as Potential Targets for Immunotherapy

Simple Summary TP53 is the most frequently mutated gene in many cancers, but it has failed to be a very effective target for treatment to date. To overcome this, we have examined what else changes in cells when the TP53 gene is mutated. We modified cells that had no TP53 expression to have one of the two most common mutations, either R175H or R273H. We examined how the presence of these TP53 mutations caused cellular changes including microscopic, gene expression and peptide presentation to the immune system. This has allowed us to identify new (secondary) targets that could be used to facilitate the treatment of tumors that harbor p53 mutations. Abstract The p53 protein is mutated in more than 50% of human cancers. Mutated p53 proteins not only lose their normal function but often acquire novel oncogenic functions, a phenomenon termed mutant p53 gain-of-function. Mutant p53 has been shown to affect the transcription of a range of genes, as well as protein–protein interactions with transcription factors and other effectors; however, no one has intensively investigated and identified these proteins, or their MHC presented epitopes, from the viewpoint of their ability to act as targets for immunotherapeutic interventions. We investigated the molecular changes that occurred after the TP53 null osteosarcoma cells, SaOS-2, were transfected with one of two conformational p53-mutants, either R175H or R273H. We then examined the phenotypic and functional changes using macroscopic observations, proliferation, gene expression and proteomics alongside immunopeptidome profiling of peptide antigen presentation in the context of major histocompatibility complex (MHC) class I molecules. We identified several candidate proteins in both TP53 mutant cell lines with differential expression when compared to the TP53 null vector control, SaOS-V. Quantitative SWATH proteomics combined with immune-peptidome analysis of the class-I eluted peptides identified several epitopes presented on pMHC and in silico analysis shortlisted which antigens were expressed in a range of cancerous but not adjacent healthy tissues. Out of all the candidates, KLC1 and TOP2A showed high levels of expression in every tumor type examined. From these proteins, three A2 and four pan HLA-A epitopes were identified in both R175H and R273H from TOP2A. We have now provided a short list of future immunotherapy targets for the treatment of cancers harboring mutated TP53.
CERENKOV RADIATION FROM THE NIGHT SKY, AND ITS APPLICATION TO $gamma$-RAY ASTRONOMY

A study was made of processes that yield gamma rays in the energy region above the threshold of the Cherenkov technique (greater than 10/sup 12/ ev) and which have a reasonable probability of occurrence. The two basic processes considered are the gamma rays from the decay of fast pi /sup o/mesons in flight and gamma rays from the Coulomb-field bremsstrahlung of fast-moving electrons colliding with nuclei in gas clouds in interstellar space. The process of Cherenkov radiation is presented and its relation to light from the night sky. Various detection means are discussed. (R.E.U.)
Novel dual band patch antenna With Gap coupled composite right/left-handed transmission line

Abstract A novel low profile dual band patch antenna is presented. It consists of a composite right/left-handed transmission line (CRLH TL) unit cell gap coupled with the radiating edge of a rectangular patch antenna. The dual band behavior is achieved by coupling the zeroth order resonance mode of CRLH TL and TM10 mode of the patch antenna. It is shown that frequency ratio can be changed by varying the gap between the patch and CRLH TL unit cell. The proposed configuration enables frequency reconfigurability by changing the CRLH TL unit cell using a switch. A prototype of the antenna having frequency ratio f2/f1 = 1.08 is designed and fabricated. The proposed antenna shows measured S11 ≤ −10 dB bandwidth of 100 and 50 MHz at resonance frequencies of f1 = 4.84 and f2 = 5.22 GHz, respectively. A 2 × 2 dual band CRLH TL coupled patch array is also presented, showing more than 12.7 dBi gain at both resonance frequencies.
A myeloperoxidase enhancer drives myeloid cell‐specific labeling in a transgenic frog line

We have identified a myeloid cell‐specific enhancer in the 5′ flanking region of the Xenopus tropicalis myeloperoxidase gene. Transgenic reporter analysis using Xenopus laevis revealed that the expression of GFP was detected in the tail fin macrophages of a swimming tadpole, and the distributions of the GFP‐positive and XL‐2 (a pan‐marker for leukocytes)‐positive cells were mostly overlapping. The GFP‐positive cells in the liver of the transgenic tadpole were localized in the same areas where the myeloid cells were present. Isolation of leukocytes from the peripheral blood cells followed by flow cytometric analysis revealed that the GFP‐positive fraction was specifically enriched in neutrophils with lobulated nuclei. Furthermore, the macrophages purified from the peritoneal cavity were also GFP‐positive. In summary, a transgenic frog line in which the myeloid cells are labeled with GFP provides a useful tool to elucidate the physiological role of myeloid cells of multiple origins in the embryo.
Prostate Cancer Secretome and Membrane Proteome from Pten Conditional Knockout Mice Identify Potential Biomarkers for Disease Progression

Prostate cancer (PCa) is the second most common cause of mortality among men. Tumor secretome is a promising strategy for understanding the biology of tumor cells and providing markers for disease progression and patient outcomes. Here, transcriptomic-based secretome analysis was performed on the PCa tumor transcriptome of Genetically Engineered Mouse Model (GEMM) Pb-Cre4/Ptenf/f mice to identify potentially secreted and membrane proteins—PSPs and PMPs. We combined a selection of transcripts from the GSE 94574 dataset and a list of protein-coding genes of the secretome and membrane proteome datasets using the Human Protein Atlas Secretome. Notably, nine deregulated PMPs and PSPs were identified in PCa (DMPK, PLN, KCNQ5, KCNQ4, MYOC, WIF1, BMP7, F3, and MUC1). We verified the gene expression patterns of Differentially Expressed Genes (DEGs) in normal and tumoral human samples using the GEPIA tool. DMPK, KCNQ4, and WIF1 targets were downregulated in PCa samples and in the GSE dataset. A significant association between shorter survival and KCNQ4, PLN, WIF1, and F3 expression was detected in the MSKCC dataset. We further identified six validated miRNAs (mmu-miR-6962-3p, mmu-miR- 6989-3p, mmu-miR-6998-3p, mmu-miR-5627-5p, mmu-miR-15a-3p, and mmu-miR-6922-3p) interactions that target MYOC, KCNQ5, MUC1, and F3. We have characterized the PCa secretome and membrane proteome and have spotted new dysregulated target candidates in PCa.