Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Systemic Propranolol Application on the New Bone Formation in Periimplant Guided Bone Regeneration

ABSTRACT Objectives The aim of this experimental animal study was to evaluate the effects of systemic propranolol on new bone formation in peri-implant bone defects. Material and Methods Implant slots were created 4mm long and 2.5 mm wide. After the titanium implants were placed in the sockets, 2 mm defects were created in the neck of the implants. Bone grafts were placed in these defects. Then the rats were randomly divided into three equal groups: control (n = 8), propranolol dose-1 (PRP-1) (n = 8), and propranolol dose-2 (PRP-2) (n = 8) groups. In the control group, the rats received no further treatment during the eight-week experimental period after the surgery. The rats in the PRP-1 and PRP-2 groups were given 5 mg/kg and 10 mg/kg propranolol, respectively, every three days for the eight-week experimental period after the surgery. At the end of the experimental period, the rats were euthanized. Blood serum was collected for biochemical analysis, and the implants and surrounding bone tissues were used for the histological analysis. Results There were no significant differences in the histological analysis results and the biochemical parameters (alkaline phosphatase, calcium, creatinine and phosphorus) of the groups (P > 0.05). Also, in the test groups, there was numerically but not statistically more new bone formation detected compared with the controls. Conclusions Within the limitations of this study, propranolol did not affect the new bone formation in peri-implant defects.
Different virulence levels of Enterococcus cecorum strains in experimentally infected meat-type chickens

In recent years, pathogenic strains of Enterococcus cecorum (EC) have emerged as a causing agent of septicemia and skeletal infection in broiler chickens with a high economic impact worldwide. Although research has been conducted, many aspects of the pathogenesis of the EC-associated disease are still unknown. In the present study, an experimental infection model was established in broiler chickens. Two different EC strains (EC14 and EC15) were compared in two different concentrations of each strain (2 × 106 and 2 × 108 colony-forming units per milliliter (CFU/mL)) after oral infection of one-day-old chicks. Clinical signs and gross lesions of the EC-associated disease were monitored in the following seven weeks. Although both EC strains were originally isolated from clinical disease outbreaks and had a high embryonic lethality, only EC14 successfully induced the typical course of the EC-associated disease with characteristic clinical signs and gross lesions. In total, 23% of the birds in the two EC14-groups were EC-positive in extraintestinal organs on culture, and no differences were found between the two infectious doses. EC14 was frequently detected via real-time PCR in the free thoracic vertebra (FTV) and femoral heads without any detectable gross lesions. The number of EC positive spleens from infected broilers was comparable using bacterial isolation and a specific real-time PCR. Interestingly, EC15 was not detected in extraintestinal organs, although birds in the EC15 groups were colonized by EC in the ceca after experimental infection. The present study represents first proof that virulence differs among EC strains in experimentally infected chickens, and emphasizes the need to further characterize virulence factors and pathogenic mechanisms of EC. The strain EC14 at a dose of 106 CFU is suitable for reproduction of the EC-associated disease. The experimental infection model reported here provides the basis for further research on the EC pathogenesis and possible prevention and intervention strategies.
Research_9757126 1..19

Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University, Nanjing 211816, China Frontiers Science Center for Flexible Electronics, Xi’an Institute of Flexible Electronics (IFE) and Xi’an Institute of Biomedical Materials & Engineering, Northwestern Polytechnical University, Xi’an 710072, China Naval Medical Department, Naval Medical University, Shanghai 200433, China The Institute of Flexible Electronics (IFE, Future Technologies), Xiamen University, Xiamen 361005, China
Low cost phased array antenna for land-mobile satcom applications

Phased array antennas for use with land-mobile satcom services have been under development for several years. Owing to the relatively modest specification required of these antennas, it should be possible to produce them at an affordable price. A number of techniques aimed at minimising the cost of such arrays without significantly sacrificing performance are considered. A prototype 18-element array embodying these techniques is described, with theoretical predictions and experimental results to substantiate array performance. >
Low-Load Blood Flow Restriction and High-Load Resistance Training Induce Comparable Changes in Patellar Tendon Properties

ABSTRACT Introduction Low-load resistance training with blood flow restriction (LL-BFR) has emerged as a viable alternative to conventional high-load (HL) resistance training regimens. Despite increasing evidence confirming comparable muscle adaptations between LL-BFR and HL resistance exercise, only very little is known about tendinous mechanical and morphological adaptations after LL-BFR. Therefore, the aim of the present study was to examine the effects of 14 wk of LL-BFR and HL training on patellar tendon adaptations. Methods Twenty-nine recreationally active male participants were randomly allocated into the following two groups: LL-BFR resistance training (20%–35% one-repetition maximum (1RM)) or HL resistance training (70%–85% 1RM). Both groups trained three times per week for 14 wk. One week before and after the intervention, patellar tendon mechanical and morphological properties were assessed via ultrasound and magnetic resonance imaging. In addition, changes in muscle cross-sectional area were quantified by magnetic resonance imaging and muscle strength via dynamic 1RM measurements. Results The findings demonstrated that both LL-BFR and HL training resulted in comparable changes in patellar tendon stiffness (LL-BFR: +25.2%, P = 0.003; HL: +22.5%, P = 0.024) without significant differences between groups. Similar increases in tendon cross-sectional area were observed in HL and LL-BFR. Muscle mass and strength also significantly increased in both groups but were not statistically different between HL (+38%) and LL-BFR (+34%), except for knee extension 1RM where higher changes were seen in LL-BFR. Conclusions The present results support the notion that both HL and LL-BFR cause substantial changes in patellar tendon properties, and the magnitude of changes is not significantly different between conditions. Further studies that examine the physiological mechanisms underlying the altered tendon properties after LL-BFR training are needed.
Interfacial characteristics and in vitro digestion of emulsion coated by single or mixed natural emulsifiers: lecithin and/or rice glutelin hydrolysates.

BACKGROUND The interfacial characteristics and in vitro digestion of emulsion were related to emulsifier types. The mean droplet diameter, ζ-potential, microstructure, interfacial tension, Quartz crystal microbalance with dissipation (QCM-D), and in vitro gastrointestinal fate of emulsions stabilized by soybean lecithin, hydrolyzed rice glutelin (HRG) and their mixture were researched. RESULT The value of interfacial tension was much more dramatically for the sample containing 20 g‧kg-1 of HRG. For QCM-D, a rigid layer was formed for all the samples after rinsing. The layer thickness were 0.87±0.20, 2.11±0.31, and 2.63±0.22 nm, and adsorbed mass were 87.17±10.31, 210.56±20.12 and 263.09±23.23 ng‧cm-2 , for HRG, lecithin and HRG/lecithin, respectively, indicating both of HRG and lecithin were adsorbed at the oil-water interface. Structure rearrangements at the interface was occurred for HRG/lecithin. The kinetics and final amount of lipid digestion depended on emulsifier type: lecithin > HRG/lecithin > HRG. These differences in digestion rate were primarily due to differences in the aggregation state of the emulsifiers. CONCLUSION The incorporation of lecithin into the HRG emulsions had better interfacial properties and facilitated lipid digestibility. These results provide important information for the rational design plant-based functional food. This article is protected by copyright. All rights reserved.
Two-Dimensional Numerical Simulation and Experiment on Large Deformation of Collapsible Tube

By using the tube law, which describes the relationship between the cross-sectional area of a collapsible tube and the transmural pressure, which is the difference between inside pressure and outside pressure, a coupled problem between flow in the tube and wall deformation is formulated. In this paper, a numerical method for calculating two-dimensional deformation of the tube is presented and the results are compared with experimental results. The calculation results are compared with those of Ref. (6) to show the validity of our calculation method in which tube wall thickness is taken into account in determining the contact behavior of the tube wall. In the experiment, we use a silicone rubber tube as the collapsible tube. The tube's cross-sectional shape is visualized by using the laser light sheet method. It is shown experimentally that the tube law calculated by dividing the inner volume of the tube by its length has a large error in the wall contact region. In the calculation in Ref. (6), tube wall thickness is not treated rigorously in the wall contact region. However, according to our results, the effect of wall thickness on the tube law is not negligible in the wall contact region.
Exploring how feedback reflects entrustment decisions using artificial intelligence

Clinical supervisors make judgements about how much to trust learners with critical activities in patient care. Such decisions mediate trainees' opportunities for learning and competency development and thus are a critical component of education. As educators apply entrustment frameworks to assessment, it is important to determine how narrative feedback reflecting entrustment may also address learners' educational needs.
Invasive wild pigs (Sus scrofa) as a human‐mediated source of soil carbon emissions: Uncertainties and future directions

Invasive wild pigs (Sus scrofa) - also known as feral pigs, feral swine, and wild hogs - have been spread by humans outside of their native range and are now established on every continent except Antarctica (Barrios-Garcia & Ballari, 2012). Through their uprooting of soil, they are known to affect food security, drive the loss of native plants and animals, and jeopardise cultural resources (Barrios-Garcia & Ballari, 2012; Risch et al., 2021; Sloane et al., 2021). In our recent article, we explored another threat from their soil disturbance: greenhouse gas emissions (O'Bryan et al., 2021). We discussed that ongoing and future management of wild pigs could bring potential co-benefits through the reduction CO2 emissions, but our analysis revealed a great deal of uncertainty that points to potential wide-ranging consequences of their management on CO2 emissions.
Higher Order Connection Enhanced Community Detection in Adversarial Multiview Networks

Community detection in multiview networks has drawn an increasing amount of attention in recent years. Many approaches have been developed from different perspectives. Despite the success, the problem of community detection in adversarial multiview networks remains largely unsolved. An adversarial multiview network is a multiview network that suffers an adversarial attack on community detection in which the attackers may deliberately remove some critical edges so as to hide the underlying community structure, leading to the performance degeneration of the existing approaches. To address this problem, we propose a novel approach, called higher order connection enhanced multiview modularity (HCEMM). The main idea lies in enhancing the intracommunity connection of each view by means of utilizing the higher order connection structure. The first step is to discover the view-specific higher order Microcommunities (VHM-communities) from the higher order connection structure. Then, for each view of the original multiview network, additional edges are added to make the nodes in each of its VHM-communities fully connected like a clique, by which the intracommunity connection of the multiview network can be enhanced. Therefore, the proposed approach is able to discover the underlying community structure in a multiview network while recovering the missing edges. Extensive experiments conducted on 16 real-world datasets confirm the effectiveness of the proposed approach.
Understanding the flavor signature of the rice grown in different regions of China via metabolite profiling.

BACKGROUND Rice is the staple food of most people in China. The fragrance of rice varies from region to region, and high-quality rice always has a pleasant aroma. To protect consumers from misleading information and fraud, and to serve the interests of high-quality rice producers, to develop a rice regional protection system in China, the phenotype of rice grown in different Chinese regions must be known. The flavor phenotype of the rice cultivated in China were studied. RESULTS The volatile organic compounds of rice sample in China have good classification potential and the 37 rice products investigated herein may be divided into three main categories: northeastern rice, central and southern rice, and Shanghai rice. Orthogonal projection to latent structure-discriminant analysis (OPLS-DA) model exhibited a good discrimination for rice samples in China. Based on selected distinctive biomarker compounds, data-driven soft independent modelling of class analogy was successfully applied to identifying the origin of samples. Moreover, the differential volatile compounds identified in this study endow the rice samples with distinctive flavor characteristics. CONCLUSION The results of this study are valuable in understanding the difference of flavor characteristics of rice grown in different regions of China, and in the identification of geographical origins to develop China's geographic protection product industry. This article is protected by copyright. All rights reserved.
Impact of Behavioral Nudges on the Quality of Serious Illness Conversations Among Patients With Cancer: Secondary Analysis of a Randomized Controlled Trial

PURPOSE: Serious Illness Conversations (SICs) are structured conversations between clinicians and patients about prognosis, treatment goals, and end-of-life preferences. Although behavioral interventions may prompt earlier or more frequent SICs, their impact on the quality of SICs is unclear. METHODS: This was a secondary analysis of a randomized clinical trial (NCT03984773) among 78 clinicians and 14,607 patients with cancer testing the impact of an automated mortality prediction with behavioral nudges to clinicians to prompt more SICs. We analyzed 318 randomly selected SICs matched 1:1 by clinicians (159 control and 159 intervention) to compare the quality of intervention vs. control conversations using a validated codebook. Comprehensiveness of SIC documentation was used as a measure of quality, with higher integer numbers of documented conversation domains corresponding to higher quality conversations. A conversation was classified as high-quality if its score was ≥ 8 of a maximum of 10. Using a noninferiority design, mixed effects regression models with clinician-level random effects were used to assess SIC quality in intervention vs. control groups, concluding noninferiority if the adjusted odds ratio (aOR) was not significantly < 0.9. RESULTS: Baseline characteristics of the control and intervention groups were similar. Intervention SICs were noninferior to control conversations (aOR 0.99; 95% CI, 0.91 to 1.09). The intervention increased the likelihood of addressing patient-clinician relationship (aOR = 1.99; 95% CI, 1.23 to 3.27; P < .01) and decreased the likelihood of addressing family involvement (aOR = 0.56; 95% CI, 0.34 to 0.90; P < .05). CONCLUSION: A behavioral intervention that increased SIC frequency did not decrease their quality. Behavioral prompts may increase SIC frequency without sacrificing quality.
Predictive factors of erectile dysfunction in Egyptian individuals after contracting COVID‐19: A prospective case–control study

This study aimed to screen healthy individuals who contracted COVID‐19 for erectile dysfunction (ED) and to determine the potential risk factors that can predict ED in these individuals. One hundred and seven cases versus 90 controls agreed to participate in the study. Two structured interviews with 1 month interval were conducted. All participants were evaluated by the validated Arabic version of the international index of erectile function (IIEF‐5) and assessment of the psychological state by Hamilton depression rating scale (HDRS). Interestingly, the study had demonstrated a significant difference in mean testosterone level between cases and controls (3.91 ± 2.31, 5.04 ± 2.22, p < 0.001 respectively). Additionally, the study had demonstrated a significant difference in mean IIEF‐5 score between cases and controls (22.63 ± 2.79, 23.54 ± 1.26, p < 0.041 respectively). Moreover, there were significant differences in mean anxiety and stress scores of the cases before and after COVID‐19 (4.95 ± 4.03, 6.19 ± 3.55, p = 0.022, 12.75 ± 9.98, 15.30 ± 7.42, p = 0.024 respectively). A multiple logistic regression model for predicting ED occurrence post‐COVID‐19 had revealed that smoking, baseline IIEF‐5 score and COVID‐19 severity (p = 0.022, p = 0.017, p = 0.021, p = 0.009, p = 0.008 respectively) were the only significant independent variables.
Long-term changes in life-history traits of Norwegian spring-spawning herring

Life-history traits are key determinants of populations’ dynamics. Those traits are susceptible to natural selection and are therefore sensitive to the mortality regime and the selection pattern a population experience. Nowadays, almost all natural populations are affected by anthropogenic activities (e.g. urbanisation, loss or segmentation of habitats). More specifically, fish stocks, reproducing in the wild and coping with environmental fluctuations, have been exploited with industrialized efficiency for decades. The effects of fisheries on exploited stocks life-history traits have been widely studied and there is currently no doubt that fisheries-induced evolution is taking place in many of them. Fisheries-induced evolution of life-history traits constitutes a challenge for management, since genetic changes are difficult to reverse, and can lead to a loss of productivity and resilience of the exploited stock. Considering the amount of evidence supporting fisheries-induced evolution, it is therefore surprising that little of it is found in an intensively exploited pelagic fish, the Norwegian spring-spawning herring. Exploited for centuries, the stock collapsed in the late 1960’s because of overfishing and took more than 15 years to recover. The fishery went from an open-access fishery to a TAC regulated fishery combined with management regulations such as a minimum landing size of 25 cm. A weak decrease in age at maturation, maybe attributable to fisheries-induced evolution, has been detected, while other traits haven’t been studied yet. The goal of this thesis is to investigate how traits other than age and length at maturation have been affected by the fishing pressure in Norwegian spring-spawning herring. In addition, it gives an overview of how the selection pressures Norwegian Spring-spawning herring is subjected to may have changed during the last century and explain the weakness of the trends observed. Using multivariate linear (mixed effect) models together with data spanning 80 years, significant residual trends, potentially attributable to genetic changes, were found for the reproductive investment (increase, Paper II) and adult growth (decrease, Paper
Nose-only inhalations of high-dose alumina nanoparticles/hydrogen chloride gas mixtures induce strong pulmonary pro-inflammatory response: a pilot study

Abstract Objective Solid composite propellants combustion, in aerospace and defense fields, can lead to complex aerosols emission containing high concentrations of alumina nanoparticles (Al2O3 NPs) and hydrogen chloride gas (HClg). Exposure to these mixtures by inhalation is thus possible but literature data toward their pulmonary toxicity are missing. To specify hazards resulting from these combustion aerosols, a pilot study was implemented. Materials and methods Male Wistar rats were nose-only exposed to Al2O3 NPs (primary size 13 nm, 10 g/L suspension leading to 20.0–22.1 mg/m3 aerosol) and/or to HClg aerosols (5 ppm target concentration) following two exposure scenarios (single exposures (SE) or repeated exposures (RE)). Bronchoalveolar lavage fluids (BALF) content and lungs histopathology were analyzed 24 h after exposures. Results Repeated co-exposures increased total proteins and LDH concentrations in BALF indicating alveolar–capillary barrier permeabilization and cytolysis. Early pulmonary inflammation was induced after RE to Al2O3 NPs ± HClg resulting in PMN, TNF-α, IL-1β, and GRO/KC increases in BALF. Both exposure scenarios resulted in pulmonary histopathological lesions (vascular congestions, bronchial pre-exfoliations, vascular and interalveolar septum edemas). Lung oxidative damages were observed in situ following SE. Conclusion Observed biological effects are dependent on both aerosol content and exposure scenario. Results showed an important pro-inflammatory effect of Al2O3 NPs/HClg mixtures on the lungs of rat 24 h after exposure. This pilot study raises concerns toward potential long-term pulmonary toxicity of combustion aerosols and highlights the importance for further studies to be led in order to define dose limitations and exposure thresholds for risk management at the work place.
Large valley polarization in a novel two-dimensional semiconductor H-ZrX2 (X = Cl, Br, I)

Inspired by the new progress in the research field of two-dimensional valleytronics materials, we propose a new class of transition metal halides, i.e. H-ZrX2 (X = Cl, Br, I), and investigated their valleytronics properties under the first-principles calculations. It harbors the spin-valley coupling at K and K′ points in the top of valence band, in which the valley spin splitting of ZrI2 can reach up to 115 meV. By carrying out the strain engineering, the valley spin splitting and Berry curvature can be effectively tuned. The long-sought valley polarization reaches up to 108 meV by doping Cr atom, which corresponds to the large Zeeman magnetic field of 778 T. Furthermore, the valley polarization in ZrX2 can be lineally adjusted or flipped by manipulating the magnetization orientation of the doped magnetic atoms. All the results demonstrate the well-founded application prospects of single-layer ZrX2, which can be considered as great candidate for the development of valleytronics and spintronics.