Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of Additive Manufacturing, Augmented Reality, Internet of Things in building Industry 4.0

As the current world is running at great speed, competition among is at an absolute level. The demand for the customized product is increasing in every sector, and this demand will get fulfilled by new types of technologies like Additive Manufacturing (AM), Augmented Reality (AR), Internet of Things (IoT), Big Data Analytics (BDA), Cyber-Physical System (CPSs), Digital Twin, Artificial Intelligence (AI) and Machine Learning (ML), etc. The combination of all these technologies will lead to a sustainable and smart manufacturing system and arises the concept of Industry 4.0 i.e., the Fourth Industrial Revolution. In this paper, we will mainly focus on concepts of Industry 4.0, Additive Manufacturing, Augmented Reality, and Internet of Things. We will also discuss the integration of modern technologies with the help of some case studies.
CD148 T Cell Activation by the Receptor-Type Cutting Edge: Negative Regulation of Human

T cell activation represents a balance between positive and negative signals delivered via distinct cell surface molecules. Many cytoplasmic protein tyrosine phosphatases are involved in regulating cellular responses by antagonizing the action of protein tyrosine kinases. CD148 is a receptor-type protein tyrosine phosphatase expressed by all human mononuclear cells. We have investigated the effect of CD148 on TCR-mediated activation of human T cells. Overexpression of wild-type, but not a phosphatase-deﬁcient, CD148 in Jurkat T cells inhibited TCR-mediated activation, evidenced by reduced expression of the early activation Ag CD69, inhibition of tyrosine phosphorylation of many intracellular proteins including the critical protein tyrosine kinase ZAP-70, and impairment of mitogen-activated protein kinase activation. Taken together, these results suggest that CD148 is an important phosphatase involved in negatively regulating the proximal signaling events during activation of Ag-speciﬁc T cells. The Journal of Immunology, 1998, 161: 3803–3807. cells undergo activation in response to signals delivered via the TCR in combination with accessory molecules including CD28 (1), LFA-1 (2), CD2 (3), CD27 (4), and CD40 ligand (5). To maintain immune equilibrium, these stimu-latory signals must be regulated by inhibitory signals delivered via molecules such as CTLA-4 (6) and killer cell inhibitory receptors (7). The interplay between positive and negative signals is regulated by protein tyrosine kinases (PTK 4 ) and protein tyrosine phosphatases (PTP) (8–10). PTP involved in lymphocyte activation include CD45 and SHP-1
Shift of The Neutral-Niche Dynamics in The Human Microbiome Under Disturbances Associated with Lifestyle Changes

the niche The fundamental Abstract Background: It is well recognized by now that human micro biome has far reaching influences on our healthy and diseases. One venue to investigate the influences can be through the study of the mechanisms of microbial community assembly and diversity maintenance. In this article, we apply a hybrid model of neutral-niche dynamics by Ofiteru et al. to reanalyze the dataset from David et al.’s study on the effects of life style to the micro biome of two individuals, aiming to explore the shift of the neutral-niche dynamics in the human micro biota. Results: We obtained two major findings. First, in gut, Faecali bacterium prausnitzii, an anti-inflammatory bacterium, exhibited high neutral dynamics, and few other species showed similar level of neutral dynamics. In contrast, in the oral micro biome, more species demonstrated high neutral dynamics. Second, we detected some bacterial species whose neutral-niche dynamics are strongly associated with the occurrences of disturbances such as change of diets and infection. Conclusions: We postulate that the difference between gut and oral micro biota could be due to the open gateway nature of oral habitat, which makes it difficult for niche-selected species to maintain. The balance shift in the neutral-niche dynamics may play an important role in dysbiosis and possess broad health implication.
Trees, Amalgams and Calogero-Moser Spaces

We describe the structure of the automorphism groups of algebras Morita equivalent to the first Weyl algebra $ A_1 $. In particular, we give a geometric presentation for these groups in terms of amalgamated products, using the Bass-Serre theory of groups acting on graphs. A key r\^ole in our approach is played by a transitive action of the automorphism group of the free algebra $ \c $ on the Calogero-Moser varieties $ \CC_n $ defined in \cite{BW}. Our results generalize well-known theorems of Dixmier and Makar-Limanov on automorphisms of $ A_1 $, answering an old question of Stafford (see \cite{St}). Finally, we propose a natural extension of the Dixmier Conjecture for $ A_1 $ to the class of Morita equivalent algebras.
On bifurcation and local rigidity of triply periodic minimal surfaces in $\mathbb R^3$

We use bifurcation theory to determine the existence of infinitely many new examples of triply periodic minimal surfaces in $\mathbb R^3$. These new examples form branches issuing from the H-family, the rPD-family, the tP-family, and the tD-family, that converge to some degenerate embedding of the families. As to nondegenerate triply periodic minimal surfaces, we prove a perturbation result using an equivariant implicit function theorem.
Electromagnetic Field Coupling to a Transmission Line—A Reciprocity-Based Approach

The electromagnetic (EM) reciprocity theorem of the time-convolution type is systematically applied to describe an EM-field-to-line coupling model interrelating the (actual) induced voltage and current quantities at the ends of a transmission line with the (testing) ones pertaining to the situation when the line operates as a transmitter. It is demonstrated that under certain conditions, the reciprocity-based coupling model is fully equivalent to the classic models of Agrawal, Taylor, and Rachidi. Furthermore, it is shown for the case of plane-wave incidence that the far-field amplitude radiated in the testing state can be used to replace the forcing functions that are traditionally expressed in terms of the excitation-field distribution along the transmission line. The reciprocity-based formulation is finally validated both analytically and numerically.
ScholarWorks @ UTRGV ScholarWorks @ UTRGV Uncovering the complex genetics of human personality: response Uncovering the complex genetics of human personality: response from authors on the PGMRA Model from authors on the PGMRA Model

Following publication of our two articles [1, 2], a critique of the methodology of Phenotype-Genotype Many-to-Many Relations Analysis (PGMRA) [1, 3, 4] questioned the validity of our results from the perspective of polygenic risk scores (PRS) [5]. We appreciate the importance of these questions, and here provide a concise discussion of the assumptions and mathematical constraints of both approa-ches. We thank this commentator and others who have discussed our articles with us for their thoughtful questions and critiques.
IMPROVEMENT OF SUN ANGLE ACCURACY FROM IN-ORBIT DATA OF A QUADRANT PHOTODIODE SUN SENSOR OF SUN ANGLE ACCURACY FROM IN-ORBIT DATA OF A QUADRANT

The sun vector is commonly used for defining a satellite attitude and many types of sensors exist for its determination. A fine pinhole sun sensor type was chosen and designed for HORYU-IV nanosatellite of Kyushu Institute of Technology. This sensor has a round-shaped hole and uses commercial off-the-shelf silicon photodiode, which consists of four small sensitive elements arranged close to each other. This type of sensors commonly uses look-up tables for providing high accuracy, which requires a large amount of data to be saved. Polynomial methods for sun vector determination were considered instead of look-up tables to avoid having a large amount of data to be saved. The influence of dead spaces between photodiodes on sensor accuracy was also investigated. The sensor was tested in space environment. It was found that its output signals went to saturation point. A method for the compensation of signals truncated by saturation was proposed. It was found that: 1) polynomial method provided 0.1deg accuracy for a sensor with ±5deg field of view; 2) accounting for gaps between photodiodes decreases the average error of the angle determined by 15%; 3) a method for compensation of truncated signals saves full sensor FOV with decreasing accuracy till 0.11deg.
Endotoxin-Induced Sepsis Homeostasis and Exacerbates Lipocalin 2 Deficiency Dysregulates Iron

Various states of inﬂammation, including sepsis, are associated with hypoferremia, which limits iron availability to pathogens and reduces iron-mediated oxidative stress. Lipocalin 2 (Lcn2; siderocalin, 24p3) plays a central role in iron transport. Accordingly, Lcn2-deﬁcient (Lcn2KO) mice exhibit elevated intracellular labile iron. In this study, we report that LPS induced systemic Lcn2 by 150-fold in wild-type mice at 24 h. Relative to wild-type littermates, Lcn2KO mice were markedly more sensitive to endotoxemia, exhibiting elevated indices of organ damage (transaminasemia, lactate dehydrogenase) and increased mortality. Such exacerbated endotoxemia was associated with substantially increased caspase-3 cleavage and concomitantly elevated immune cell apoptosis. Furthermore, cells from Lcn2KO mice were hyperresponsive to LPS ex vivo, exhibiting elevated cytokine secretion. Additionally, Lcn2KO mice exhibited delayed LPS-induced hypoferremia despite normal hepatic hepcidin expression and displayed decreased levels of the tissue redox state indicators cysteine and glutathione in liver and plasma. Desferroxamine, an iron chelator, signiﬁcantly protects Lcn2KO mice from LPS-induced toxicity, including mortality, suggesting that Lcn2 may act as an antioxidant in vivo by regulating iron homeostasis. Thus, Lcn2-mediated regulation of labile iron protects the host against sepsis. Its small size and simple structure may make Lcn2 a deployable treatment for sepsis. The Journal of Immunology ,
Optimization And Performance Analysis Of Transceiver Front End Low Power Low Noise Amplifier

:- A Frequency range of 2.4-2.5 GHz is intentionally reserved for industrial, scientific and medical (ISM) radio purposes. The receiver sensitivity is a function of signal-to- noise ratio, receiver bandwidth and receiver noise figure. Low-noise amplifier (LNA) being the first building block of a front-end receiver after antenna establishes the overall noise figure (NF). The design of the front-end low noise amplifier (LNA) is one of the challenges in Radio Frequency (RF) receivers. Major difficulties of RF CMOS circuit implementation are relatively lower unity-gain frequency and poor noise performances. Many high gain amplifier topologies have been proposed as a way to satisfy the requirement for low power dissipation as well as improved performances. This thesis work focus on Design of Optimized Transceiver Front-end Low Power Low Noise Amplifier in 0. 18µm CMOS technology.
OVERALL SURVIVAL ANALYSIS OF HEPATOID ADENOCARCINOMA OF THE LUNG

: Background: Hepatoid Adenocarcinoma of lung (HAL) is very rare and aggressive malignant tumor originated in the lungs. The exact features of the disease are still unclear because very less data available about this disease.We conduct this SEER (surveillance epidemiology and end result) database to illuminate the characteristics overall survival (OS) and prognosis of HAL. Materials and Method: We obtained this data from the SEER database between the year 2010 - 2015. Patient demographic and disease information statistics was compared by using the pearson chi-square test and binary logistic regression. Propensity score matching (PSM) was performed using the package in R, version 3.3. 1 (R Foundation). Results: In unmatched data we have hepatoid adenocarcinoma of the lung (HAC) 42 patients and adenocarcinoma of the lung (AC) 111426 patients. In matched data we have HAC 42 patients and AC 208 Patients and following are the results. In the unmatched data there are some imbalances in the certain characteristics such as age at diagnosis, year of diagnosis, grade and surgery, there is no imbalances in the matched data. The estimated OS time before propensity score matching (PSM) in HAC of the lung is 4 months and AC of the lung is 13 months, and the estimated OS time after PSM in HAC of the lung is also 4 months while AC of the lung is 9 months. Conclusion: Most of the HAC of the lung patients present in the advance age, the gender ratio is almost same, the OS of the disease before PSM and after PSM is very poor.
Services Export Diversification and Economic Growth CURRENT STATUS: POSTED

The present article investigates the effect of services export diversification on economic growth by relying on a sample of 131 countries over the period 1985-2014. The empirical results, based on the two-step system Generalized Methods of Moments (GMM), has suggested that services export diversification enhances economic growth in developing countries, whereas in High Income Countries (HICs), services export specialization promotes economic growth. Furthermore, services export diversification enhances economic growth as countries experience a rise in their services exports growth, with the magnitude of this positive effect increasing as the growth rate of services exports rises. Finally, services export diversification tends to be positively associated with economic growth, but as countries enjoy greater trade openness, they tend to enhance their services export specialization so as to enjoy higher economic growth. Interestingly, it is services export specialization that promotes economic growth as countries better integrate into the international trade market. One key message conveyed by the analysis is the importance of services export diversification (or concentration) for economic growth, including when countries further open up to international trade.
Respondent-driven sampling on directed networks

: Respondent-driven sampling (RDS) is a widely used method for generating chain-referral samples from hidden populations. It is an extension of the snowball sampling method and can, given that some assumptions are met, generate unbiased population estimates. One key assumption, not likely to be met, is that the acquaintance network in which the recruitment process takes place is undirected, meaning that all recruiters should have the potential to be recruited by the person they recruit. Using a mean-ﬁeld approach, we develop an estimator which is based on prior information about the average indegrees of estimated variables. When the indegree is known, such as for RDS studies over internet social networks, the estimator can greatly reduce estimate error and bias as compared with current meth- ods; when the indegree is not known, which is most common for interview-based RDS studies, the estimator can through sensitivity analysis be used as a tool to account for uncertainties of network directedness and error in self-reported degree data. The performance of the new estimator, together with previous RDS estimators, is investigated thoroughly by simulations on networks with varying structures. We have applied the new estimator on an empirical RDS study for injecting drug users in New York City.
Trypanocidal Activity of Genzyme 644131, an Adenosylmethionine Decarboxylase Inhibitor

Genzyme 644131, 8-methyl-5’-{[(Z)-4-aminobut-2-enyl](methylamino)}adenosine, is an analog of the enzyme activated S-adenosylmethionine decarboxylase (AdoMetDC) inhibitor and trypanocidal agent MDL-7381, 5-{[(Z)-4-aminobut-2-enyl](methylamino)}adenosine. The analog differs from the parent in having an 8-methyl group on the purine ring which bestows favorable pharmacokinetic, biochemical and trypanocidal activities. The compound was curative in acute Trypanosoma brucei brucei and drug-resistant Trypanosoma brucei rhodesiense model infections, with single-dose activity in the 1-5 mg/kg/day QD dose range for 4 days against T. b. brucei , and 25-50 mg/kg BID dosing against T. b. rhodesiense infections. The compound was not curative in the TREU 667 CNS model infection, but cleared blood parasitemia and extended time to recrudescence in several groups. The study shows that AdoMetDC remains an attractive chemotherapeutic target in African trypanosomes and chemical changes in AdoMetDC inhibitors can produce more favorable drug characteristics than the lead compound.
The Emergence of Nanotechnology and its Applications

The emergence of nanotechnology has led to the design, synthesis, and manipulation of particles in order to create a new opportunity for the utilization of smaller and more regular structures for various applications. In recent years, nanosized metal oxide particles have gotten much attention in various fields of application due to its unique optical, electrical, magnetic, catalytic and biomedical properties as well as their high surface to volume ratio and specific affinity for the adsorption of inorganic pollutants and degradation of organic pollutants in aqueous systems [1-29].
STABILITY ANALYSIS OF A LEVELLING NETWORK AS A PRELUDE TO A RESIDENTIAL BUILDING CONSTRUCTION

Summary: The significance of geodetic deformation monitoring during the construction of any type of civil engineering structure is a well-known matter. Many classical and sophisticated geodetic monitoring methods employing total station, GNSS, laser scanning, photogrammetric and other technologies have been developed and are actively in use. Nevertheless, precise geometric levelling is still one of the most accurate of all geodetic measurement methods. This paper presents a practical example of deformation analysis being applied to a monitoring levelling network established for the determination of vertical displacements of a residential building in Zagreb in the Republic of Croatia. Before the construction start, the stability of the monitoring network has been analyzed in two measurement epochs and vertical displacements of the network’s benchmarks have been determined by applying the Karlsruhe deformation analysis method. All relevant results are presented.
Kaposi’s Sarcoma-Associated Herpesvirus Infection Promotes Invasion of Primary Human Umbilical Vein Endothelial Cells by Inducing Matrix Metalloproteinases (cid:1)

Matrix metalloproteinases (MMPs) play important roles in cancer invasion, angiogenesis, and inﬂammatory inﬁltration. Kaposi’s sarcoma is a highly disseminated angiogenic tumor of proliferative endothelial cells linked to infection by Kaposi’s sarcoma-associated herpesvirus (KSHV). In this study, we showed that KSHV infection increased the invasiveness of primary human umbilical vein endothelial cells (HUVEC) in a Matrigel-based cell invasion assay. KSHV-induced cell invasion was abolished by an inhibitor of MMPs, BB-94, and occurred in both autocrine- and paracrine-dependent fashions. Analysis by zymography and Western blotting showed that KSHV-infected HUVEC cultures had increased secretion of MMP-1, -2, and -9. KSHV increased the secretion of MMP-2 within 1 h following infection without upregulating its mRNA expression level. In contrast, the secretion of MMP-1 and -9 was not increased until 6 h after KSHV infection and was correlated with the upregulation of their mRNA expression levels. Promoter analysis by reporter assays and electrophoretic mobility shift assays identiﬁed an AP-1 cis -element as the dominant KSHV-responsive site in the MMP-1 promoter. Together, these results suggest that KSHV infection modulates the production of multiple MMPs to increase cell invasiveness and thus contributes to the pathogenesis of KSHV-induced malignancies. incubated 24 h other- wise. were able to degrade the Matrigel layer and migrated to the lower surface of the ﬁlter were ﬁxed with 70% ethanol, stained with hematoxylin and eosin, and counted under a light microscope. For each experiment, three to ﬁve wells were used for each treatment. Five random ﬁelds were counted for each well, and the average cell number per ﬁeld in a well was calculated. To evaluate the role of MMPs in KSHV-mediated cell invasion, a broad-spectrum synthetic inhibitor of MMPs, BB-94 (British Biotechnology, Oxford, United Kingdom), was added to both the insert and lower chamber of the transwell system at a ﬁnal concentration of 10 (cid:2) g/ml during the assay. To evaluate paracrine-mediated cell invasion, normal HUVEC were examined in the invasion assay in the presence of supernatants from mock- or KSHV-infected HUVEC cultures. The supernatants were collected at 24 hpi and subjected to high-speed centrifugation at 20,000 (cid:3) g for 2 h toeliminate any cellular debris and virions before the invasion assay. The absence of any infectious virions in the supernatants was conﬁrmed by virus titration as previously described 51).
A REVIEW ON IMPORTANCE OF B-TYPE NATRIURETIC PEPTIDE IN DIAGNOSIS AND MANAGEMENT OF HEART FAILURE IN EMERGENCY DEPARTMENT

Heart failure is the major and increasing cause of death and disability worldwide. Heart failure is often difficult to diagnose with the symptoms and physical findings. Identification of circulatory biomolecules that may provide new windows into the diagnosis and management of cardiovascular diseases. The natriuretic peptide plays an important role in diagnosis and management of heart diseases in present scenario. Misdiagnosis of congestive heart failure can be life threatening, because treatments for congestive heart failure are hazardous to patients with other conditions, such as chronic obstructive pulmonary disease. The natriuretic peptide consists of three peptides, the A type peptide (ANP: Released from atria), the B type peptide (BNP: Released from ventricles) and the C type peptide (CNP: released from endothelial cells). B-type natriuretic peptide is a neurohormone which is released directly from the ventricles in response to volume expansion and pressure overload. In patients with left ventricular dysfunction we can see the elevated levels of BNP. BNP levels are significantly higher in patients with dyspnea because of heart failure than from the cause. The B-type natriuretic peptide has very short half-life i.e. 22 min and thus reflects the current movement of ventricular overload. BNP is more accurate than the ejection fraction or ANP for predicting the diagnosis of congestive heart failure. BNP may distinguish the cardiac and non-cardiac causes of acute dyspnea in emergency department. To provide cost effective treatment for patients with congestive heart failure, rapid and accurate differentiation of congestive heart failure from another causes of dyspnea must be accomplished.