Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors Affecting Turmeric Production in Sunsari District, Nepal

— A study was conducted in Barahachhetra Municipality of Sunsari district from April to August, 2021 with the objectives to study factors affecting turmeric production. For the study, 100 respondents were selected through a simple random sampling method. A properly design questionnaire was administered for primary data after pretesting it. Secondary data was obtained from journals, research articles, publications, and reports. The obtained data were analyzed using computer software packages such as: MS excel (2016) and SPSS (V 26.0). The correlation coefficient tested the strength of the relationship between various dependent and independent variables. In the study, the majority of respondents were male about 68% with a literacy rate of 68% whereas, 63 respondents use their own production as seed sources. The study showed that educational status, seed treatment, Irrigation practices, cropping system, training, and product demand had a positive and significant relationship with the level of production. Similarly, seed quantity, manure quantity, labor cost, and land size under turmeric cultivation were found to have a positive and significant correlation with the level of production with a Pearson correlation coefficient of 0.525, 0.230, 0.511, and 0.791respectively. Quality planting materials, proper irrigation facilities, training related to cultivation, seed treatment should be provided to the farmers.
Development of an IEEE 1588 Simulator and Analysis of UAVs’ Synchronization in a FANET environment

— The application of IEEE 1588 standard is becoming quite common in distribution of synchronization information in packet networks. Studies of synchronization accuracy that can be reached with PTP protocol, defined in IEEE 1588 are essential for application design, both in telecommunications and in sensors industry. This article presents a new strategy for simulation of distribution synchronization which is more scalable and where simulation time is better controlled. We propose a strategy to use this simulation technique in a FANET environment where the synchronization information exchange is impaired by nodes movement, besides traffic bottlenecks in the network.
PPA_A_239196 781..793

Michelle McNamara Diane M Turner-Bowker 2 Hal Westhead 3 Andrew Yaworsky Andrew Palladino 4 Hillary Gross 1 Andy Pleil 5 Jane Loftus 1Adelphi Research, Doylestown, PA, USA; 2Adelphi Values, Boston, MA, USA; 3Adelphi Research, Manchester, UK; 4Pfizer, Inc., Collegeville, PA, USA; 5Endpoints and Evidence, LLC, Surf City, NC, USA; 6Pfizer Ltd., Tadworth, UK Introduction: The daily injection burden of recombinant human growth hormone (r-hGH) replacement therapy to treat growth hormone deficiency (GHD) may reduce compliance and limit treatment benefit. Research is needed to evaluate patient preferences for GHD injection regimen and device features. Objective: Quantitatively evaluate factors driving preferences for r-hGH injection regimen and device features among pediatric (3–17 years, and caregivers) and adult (≥25 years) patients with GHD using a discrete choice experiment (DCE) approach. Methods: The DCE was part of a broader, cross-sectional observational field study to develop clinical outcome assessments (COAs) that assess the experience of patients taking r-hGH injections. Following ethics approval, discrete choice data were collected through an online questionnaire from consented participants recruited from eight sites in the United States. Participants were presented with 20 choice tasks, each comprising different combinations of two profiles. Participants were then shown the same set of three hypothetical device and injection profiles (ie, storage, preparation, injection type device, maintenance, dose setting, injection schedule) and asked whether they would choose each profile over their current device and schedule. Choice-based conjoint analyses were used to estimate the marginal utilities and values for treatment attributes. Subject preferences were estimated at individual and aggregate levels. Results: Two hundred and twenty-four participants completed the DCE (n=75 adults, n=79 adolescent/caregiver dyads, n=70 child/caregiver dyads). Injection schedule was the strongest predictor of choice for the total sample and each patient group. Less frequent injection schedules were more likely to be chosen by participants. A “ready to use” injection was preferred, with no preference for auto-injector versus needle-free device. Most participants would choose the hypothetical injection devices and less frequent dosing over their current daily administered device schedule. Conclusion: Patients prefer a less frequent injection regimen for treating GHD. Addressing patient preferences may improve compliance, adherence, and ultimately, clinical outcomes.
The Extended Stochastic Integral in Linear Spaces with Differentiable Measures and Related Topics

Stochastic calculus in Weiner space extended stochastic integral in Weiner space randomized extended stochastic integrals with jumps introduction to the theory of differentiable measures extended vector stochastic integral in Sobolev spaces of Weiner functionals stochastic integrals and differentiable meaures differential properties of mixtures of Gaussian measures surface measures in Banach space heat potentials on Hilbert space.
In vitro anti-biofilm activity of the freshwater bryozoan Hyalinella punctata : a case study of Pseudomonas aeruginosa PAO1

The anti-biofilm and possible anti-quorum sensing effects against the strain Pseudomonas aeruginosa PAO1 of five crude extracts of the freshwater bryozoan Hyalinella punctata (Hancock, 1850) was evaluated in vitro for the first time. H. punctata ethyl acetate extract (HpEtAc) exhibited the highest anti-biofilm activity reducing the biofilm formation of P. aeruginosa PAO1 in the range of 80.63-88.13%. While all tested extracts reduced the twitching motility of the aforementioned bacterial strain, HpEtAc showed to be the most effective. Finally, at a concentration of 0.5 MIC, the same extract mostly inhibited the production of pyocyanin by P. aeruginosa PAO1 (71.53%). In comparison both with the positive controls used (streptomycin and ampicillin, 67.13 and 69.77%, respectively), HpEtAc was found to inhibit pyocyanin in a higher extent. An extensive chemical characterisation of this particular extract may result in isolation and identification of novel lead compounds targetting P. aeruginosa , an opportunistic human pathogen.
LYMPHOID NEOPLASIA Pyk2 promotes tumor progression in multiple myeloma

of Pyk2 reduced activation of Wnt/ -catenin -catenin, downregulation of and Cyclin D1. Furthermore, treatment of MM cells with the FAK/Pyk2 inhibitor VS-4718 effectively inhibited MM cell growth both in vitro and in vivo. Collectively, ourfindingsdescribethetumor-promotingroleofPyk2inMM,thusprovidingmolecularevidenceforanoveltyrosinekinaseinhibitor as a new therapeutic option in MM. ( Blood . 2014;124(17):2675-2686) 5 m g/mL insulin, 1 m g/mL hydrocortisone, and penicillin (100 U/mL)/streptomycin (100 m g/mL). The biochemical potency of VS-4718 against FAK and Pyk2 was determined at Invitrogen using the SelectScreen Z 9 -LYTE standard assay conditions (Life Technologies). The cellular potency of VS-4718 against FAK and Pyk2 was determined using p-FAK (Y397) and p-Pyk2 (Y402) enzyme-linked immunosorbent assays We then examined the effect of Pyk2
Plant growth promoting potential of rhizobacteria from Ulmus wallichiana : An endangered plant of Western Himalayas

This paper presents a pioneer study on the evaluation of plant growth promoting potential of bacteria associated with rhizosphere of Ulmus wallichiana , considering the endangered status of this taxon. Ulmus wallichiana (family: Ulmaceae) is a rare and endemic mountain tree of western Himalayas and is one of the richest emporiums for medical taxa. Three sites viz . , Chansari, Jari and Naggar were selected for the collection of rhizospheric soil samples of Ulmus wallichiana in Kullu district of Himachal Pradesh, India. Collected samples were processed for the enumeration of rhizobacteria using Standard Plate Count Technique. In total, 21 different bacterial morphotypes were obtained from all the samples. All the isolates were screened for their multifarious plant growth promoting attributes viz . , phosphate solubilisation, nitrogen fixation, siderophore, HCN, ammonia production and lytic enzymes production etc. Out of total 21 isolates, 9 were found to be P-solubilizers while 7 were siderophore producers. All the isolates were found to be positive for nitrogen fixing ability as well as ammonia production. Similarly, all isolates showed the production of IAA-like auxins ranging from 2.2-187.8 μg mL -1 . These rhizobacteria were also screened for their lytic enzymes production. Of these, only 6, 2, 3 and 1 isolates displayed considerable protease, pectinase, lipase and cellulase activities, respectively. Evaluation of their in-vitro PGP potential suggests their substantial role as growth promoters and biocontrol agents.
GLAST, LAT and GRBs

The GLAST Large Area Telescope (LAT) is the next generation satellite experiment for high‐energy gamma‐ray astronomy. It is a pair conversion telescope built with a plastic anticoincidence shield, a segmented CsI electromagnetic calorimeter, and the largest silicon strip tracker ever built. It will cover the energy range from 30 MeV to 300 GeV, shedding light on many issues left open by its predecessor EGRET. One of the most exciting science topics is the detection and observation of gamma‐ray bursts (GRBs). In this paper we present the work done so far by the GRB LAT science group in studying the performance of the LAT detector to observe GRBs. We report on the simulation framework developed by the group as well as on the science tools dedicated to GRBs data analysis. We present the LAT sensitivity to GRBs obtained with such simulations, and, finally, the general scheme of GRBs detection that will be adopted on orbit.
Effect of Fe and Zn enriched organics on yield, quality and nutrient uptake by summer groundnut

An experiment was conducted to study the “Effect of Fe and Zn enriched organics on yield, quality and nutrient uptake by summer groundnut [ Arachis hypogaea (L.)]. ” at C. P. College of Agriculture, SDAU, Sardarkrushinagar during summer, 2017. Total ten treatments were tried in randomized block design with three replications. Treatment consists of an application of FYM and vermicompost alone, applying the iron and zinc as such with FYM and Vermicompost as well as enriched with organics (FYM & Vermicpmpost). An application of RDF + 0.2 t vermicompost ha -1 enriched with 0.75 kg Zn ha -1 produced significantly higher numbers of filled pods per plant (25.60), total pods per plant (28.33), pod weight per plant (15.26 g), 100 kernel weight (41.85 g), pod yield (2537 kg ha -1 ) and haulm yield (3644 kg ha -1 ) but it was remained at par with all Fe or Zn enriched organics treatments. The total uptake of N, P and S by groundnut crop were significantly higher under Fe or Zn enriched organics (FYM or vermicompost) treatments. The application of RDF + 0.2 vermicompost/ha enriched with 1.5 kg Fe/ha recorded significantly the highest uptake of Fe (3682 g/ha) by groundnut, while total uptake of Zn (188.8) by groundnut crop was significantly higher under RDF + 0.2 t vermicompost/ha enriched with 0.75 kg Zn/ha. The available N and P 2 O 5 content in soil were significantly increased under Fe or Zn enriched organics (FYM or vermicompost) treatments. The significant improvement in available S status in all treatments which are received the Fe and Zn in the form of ferrous sulphate and zinc sulphate, respectively. The significant higher build-up of Fe and Zn content were found with their application through enrichment as well as through straight application of Fe and Zn.
Thymidylate Depletion Stimulates Homologous Recombination by UNG1 -Dependent and UNG1 Independent Mechanisms in Saccharomyces cerevisiae

Folate depletion increases the incidence of birth defects and triggers chromosomal breakage and homologous recombination. Inadequate levels of folates alter nucleotide balance by reducing thymidylate, leading to uracil incorporation into DNA. However, cellular DNA repair mechanisms that trigger homologous recombination in folate depleted cells are not well understood. We determined which types of homologous recombination events increase in budding yeast after wild type and ung1 mutants, defective in uracil glycosylase, are exposed to Methotrexate (MTX), a chemotherapeutic drug that inhibits dihydrofolate reductase and thus leads to a deficiency of tetrahydrofolate and thymidylate. We measured unequal sister chromatid exchange (SCE) in haploid strains containing tandem his3 fragments, his3 - Δ5’ and his3 - Δ3’ , and chromosomal translocations in diploid strains containing his3 - Δ5’ and his3 - Δ3’ positioned on chromosomes II and IV, respectively. We measured homolog recombination in diploid strains containing two non-reverting ade2 alleles , ade2-a and ade2-n (heteroallelic recombination). After wild type ( UNG1 ) strains were exposed to MTX, we observed five-fold and 10-fold higher rates of SCE and translocations, respectively, but after ung1 strains were exposed to MTX, we observed a two-fold maximum increase in recombination rates. We observed 14-fold higher rates heteroallelic recombination in either wild type or ung1 strains after exposure to MTX. These data indicate that UNG1 - dependent mechanisms participate in MTX-associated reciprocal exchange events, while UNG1 -independent mechanisms participate in MTX-associated gene conversion events. We suggest that there are multiple pathways by which thymidylate stress stimulates homologous recombination in yeast. this manuscript, we measured different types of recombination events that are stimulated after MTX exposure. We observed that sister chromatid exchange (SCE), homolog (heteroallelic) recombination, and non-homologous recombination events were stimulated by MTX exposure. Both rates of MTX-associated translocation and SCE were reduced in ung1 mutants, while heteroallelic recombination events were not. We suggest that both UNG1 -dependent and independent events are important in stimulating recombination that results from MTX-associated nucleotide imbalance.
Histopathological Examination of Skin in Electrocution Deaths: One Year Autopsy Study

Electrical injuries are essentially accidental. There is significant morbidity and mortality associated with electric injury. Simple safety measures can prevent accidental electrical injuries. This is an observational retrospective study done in the department of Pathology. This was a one year study. The study year being 2016. Our aim was to study the histomorphology of the skin in electrocution deaths. The maximum cases of electrocution deaths were due to low voltage (220-240V). This is the voltage supply for the domestic and minor industries. The unique finding of the study was three accidental electrocution deaths by touching the electric farm fence, which are constructed to prevent the entry of wild animals which destroy the crops in the field. Skin is the most frequently involved tissue in electrocution. We studied skin samples from 29 cases of electrocution deaths. All 29 were accidental deaths. There were 76% males. Upper extremity was the chief area of wounding. The skin samples received showed denudation in 76% cases. The most common histopathological findings were nuclear streaming (96%), dermoepidermal separation (96%) and coagulative necrosis (89%). Electrocution deaths is one of the important cause of negative autopsy. The histopathological examination of the skin coupled with the circumstantial evidence, proper and complete inspection of the crime site can be very helpful to the forensic surgeon in arriving at the diagnosis of electrocution deaths.
Qualitative stability analysis of multicriteria combinatorial minimin problems

: A multicriteria combinatorial problem with minimin partial criteria is considered. Necessary and suﬃcient conditions for the ﬁve known stability types of the problem are obtained. These stability types describe in diﬀerent ways the behavior of the Pareto and lexicographic sets of the problem under initial data perturbations of the vector criteria.
Auditory brain-stem, middle- and long-latency evoked potentials in mild cognitive impairment

Objective : Mild cognitive impairment (MCI) is a selective episodic memory deﬁcit in the elderly with a high risk of Alzheimer’s disease. The amplitudes of a long-latency auditory evoked potential (P50) are larger in MCI compared to age-matched controls. We tested whether increased P50 amplitudes in MCI were accompanied by changes of middle-latency potentials occurring around 50 ms and/or auditory brain-stem potentials. Methods : Auditory evoked potentials were recorded from age-matched controls ( n Z 16) and MCI ( n Z 17) in a passive listening paradigm at two stimulus presentation rates (2/s, 1/1.5 s). A subset of subjects also received stimuli at a rate of 1/3 s. Results : Relative to controls, MCI subjects had larger long-latency P50 amplitudes at all stimulus rates. Signiﬁcant group differences in N100 amplitude were dependent on stimulus rate. Amplitudes of the middle-latency components (Pa, Nb, P1 peaking at approximately 30, 40, and 50 ms, respectively) did not differ between groups, but a slow wave between 30 and 49 ms on which the middle-latency components arose was signiﬁcantly increased in MCI. ABR Wave V latency and amplitude did not differ signiﬁcantly between groups. Conclusions : The increase of long-latency P50 amplitudes in MCI reﬂects changes of a middle-latency slow wave, but not of transient middle-latency components. There was no evidence of group difference at the brain-stem level. Signiﬁcance : Increased slow wave occurring as early as 50 ms may reﬂect neurophysiological consequences of neuropathology in MCI. q reserved.
Thermal Hydraulic Analyses of LEU Target Plates for Mo-99 Production

Conversion from mastered High-Enriched Uranium to Low Enriched Uranium target for Molybdenum production constituted a challenge for nuclear engineering to evaluate its behavior during the three phases (irradiation, cooling and post irradiation). The present work is a contribution to thermal hydraulic analysis of Low Enriched Uranium target plate’s behavior during irradiation using CFD model. Neutronic calculation, target properties and cooling parameters of Korea Atomic Energy Research Institute (KAERI) research group were used as an input in our model. The results obtained with CFD numerical model show that the irradiation conditions are below thermal margins and are approximately close to those obtained by using TMAP code. The developed CFD model will be extended to analyze the thermal hydraulic behavior of Low Enriched Uranium target plates at cooling period (natural convection) and at transfer period (in contact with air).
The impact of estimation uncertainty on covariate effects in nonlinear models

Covariate eﬀects are a key consideration in model evaluation, fore-casting, and policy analysis, yet their dependence on estimation uncertainty has been largely overlooked in previous work. We discuss several approaches to covariate eﬀect evaluation in nonlinear models, examine computational and reporting issues, and illustrate the practical implications of ignoring estimation uncertainty in a simulation study and applications to educational attainment and crime. The evidence reveals that failing to consider estimation variability and relying solely on parameter point estimates may lead to nontrivial biases in covaraite eﬀects that can be exacerbated in certain settings, underscoring the pivotal role that estimation uncertainty can play in this context.
High efficient infrared-light emission from silicon LEDs

Since 1965 the number of transistors on a single integrated circuit (IC) forminimum component costs has been almost doubling each 18 months, a phenomenon which is known as Moore’s law. The most advanced ICs contain more than a billion transistors and the line-width used in the next generation CMOS-processes is 32 nm. It is expected that in the coming decade the exponential increase in complexity will start saturating because we are approaching fundamental limits, and new approaches are being explored to push the development further after the saturation of conventional microelectronic technology. Instead of electrical interconnects, optical integration is suggested to be used in microelectronics. Furthermore, silicon nowadays remains the first material for IC technology. Meanwhile, a compact high-speed efficient silicon light source being suitable for on-chip integration process is still missing. The aim of this research is to investigate this missing component. This dissertation presents an exploration on infrared-light emitting probability in silicon light emitting devices (Si-LEDs) with new approaches to improve the routinely low emission efficiency of silicon. It starts with a theoretical calculation of the possible internal quantum efficiency in bulk-Si LEDs and SOI-LEDs, after that a model for calculating the relationship between internal and external efficiencies is introduced. Following that the experimentally achieved results from our realized LED structures implementing the theoretical predictions are exhibited subsequently.
Country-Speciﬁc Interests towards Fall Detection from 2004–2021: An Open Access Dataset and Research Questions

: Falls, which are increasing at an unprecedented rate in the global elderly population, are associated with a multitude of needs such as healthcare, medical, caregiver, and economic, and they are posing various forms of burden on different countries across the world, specifically in the low- and middle-income countries. For these respective countries to anticipate, respond, address, and remedy these diverse needs either by using their existing resources, or by developing new policies and initiatives, or by seeking support from other countries or international organizations dedicated to global public health, the timely identification of these needs and their associated trends is highly necessary. This paper addresses this challenge by presenting a study that uses the potential of the modern Internet of Everything lifestyle, where relevant Google Search data originating from different geographic regions can be interpreted to understand the underlining region-specific user interests towards a specific topic, which further demonstrates the public health need towards the same. The scientific contributions of this study are two-fold. First, it presents an open-access dataset that consists of the user interests towards fall detection for all the 193 countries of the world studied from 2004–2021. In the dataset, the user interest data is available for each month for all these countries in this time range. Second, based on the analysis of potential and emerging research directions in the interrelated fields of Big Data, Data Mining, Information Retrieval, Natural Language Processing, Data Science, and Pattern Recognition, in the context of fall detection research, this paper presents 22 research questions that may be studied, evaluated, and investigated by researchers using this dataset.