Miracle-dz/UniFAR-FTUs huggingface dataset:
Transcription of a yeast phosphoglucomutase isozyme gene is galactose inducible and glucose repressible

The Saccharomyces cerevisiae GAL5 (PGM2) gene was isolated and shown to encode the major isozyme of phosphoglucomutase. Northern (RNA) blot hybridization revealed that the GAL5 transcript level increased three- to fourfold in response to galactose and was severely repressed in response to glucose. Total cellular phosphoglucomutase activity was likewise responsive to galactose and to glucose, and this responsiveness was found to be due primarily to variation in the activity of the major isozyme of phosphoglucomutase. These results imply that the major and minor isozymes of phosphoglucomutase have distinct roles in yeast cells. The galactose inducibility of GAL5 was found to be under the control of the GAL4, GAL80, and GAL3 genes. In striking contrast to other galactose-inducible genes, the GAL5 gene exhibited an unusually high GAL4-independent basal level of expression. These results have implications for metabolic trafficking.
Explainable Fall Risk Prediction in Older Adults Using Gait and Geriatric Assessments

Older adults aged 65 and above are at higher risk of falls. Predicting fall risk early can provide caregivers time to provide interventions, which could reduce the risk, potentially avoiding a possible fall. In this paper, we present an analysis of 6-month fall risk prediction in older adults using geriatric assessments, GAITRite measurements, and fall history. The geriatric assessments included were Activities of Daily Living (ADL), Instrumental Activities of Daily Living (IADL), Mini-Mental State Examination (MMSE), Geriatric Depression Scale (GDS), and Short Form 12 (SF12). These geriatric assessments are collected by staff nurses regularly in senior care facilities. From the GAITRite assessments on the residents, we included the Functional Ambulatory Profile (FAP) scores and gait speed to predict fall risk. We used the SHAP (SHapley Additive exPlanations) approach to explain our model predictions to understand which predictor variables contributed to increase or decrease the fall risk for an individual prediction. In case of a high fall risk prediction, predictor variables that contributed the most to elevate the risk could be further examined by the health providers for more personalized health interventions. We used the geriatric assessments, GAITRite measurements, and fall history data collected from 92 older adult residents (age = 86.2 ± 6.4, female = 57) to train machine learning models to predict 6-month fall risk. Our models predicted a 6-month fall with an AUC of 0.80 (95% CI of 0.76–0.85), sensitivity of 0.82 (95% CI of 0.74–0.89), specificity of 0.72 (95% CI of 0.67–0.76), F1 score of 0.76 (95% CI of 0.72–0.79), and accuracy of 0.75 (95% CI of 0.72–0.79). These results show that our early fall risk prediction method performs well in identifying residents who are at higher fall risk, which offers care providers and family members valuable time to perform preventive actions.
Effect of disjoining pressure in a thin film equation with non-uniform forcing

We explore the effect of disjoining pressure on a thin film equation in the presence of a non-uniform body force, motivated by a model describing the reverse draining of a magnetic film. To this end, we use a combination of numerical investigations and analytical considerations. The disjoining pressure has a regularizing influence on the evolution of the system and appears to select a single steady-state solution for fixed height boundary conditions; this is in contrast with the existence of a continuum of locally attracting solutions that exist in the absence of disjoining pressure for the same boundary conditions. We numerically implement matched asymptotic expansions to construct equilibrium solutions and also investigate how they behave as the disjoining pressure is sent to zero. Finally, we consider the effect of the competition between forcing and disjoining pressure on the coarsening dynamics of the thin film for fixed contact angle boundary conditions.
Coronary heart disease mortality in the Western Collaborative Group Study. Follow-up experience of 22 years.

In 1960-1961, 3,154 healthy, middle-aged men were entered into the Western Collaborative Group Study, a long-term study of coronary heart disease. A 22-year mortality follow-up of this cohort in 1982-1983 accounted for almost 99% of the cohort, and determined that 214 of the men had died of coronary heart disease. The risk of coronary heart disease mortality was studied for several variables measured at baseline, i.e., Type A/B behavior, systolic blood pressure, serum cholesterol level, cigarette smoking status, and age. Using a proportional hazards regression model, systolic blood pressure, serum cholesterol level, cigarette smoking status, and age were highly significant predictors (p less than 0.001) of 22-year coronary heart disease mortality. Type A/B behavior showed no association with 22-year coronary heart disease mortality (standardized relative hazard (SRH) = 0.98, 95% confidence interval (CI) = 0.85-1.12). Systolic blood pressure, serum cholesterol, and age showed relatively consistent positive associations with coronary heart disease mortality over four successive time intervals after the baseline examination. Cigarette smoking showed a significant positive association in the first and second intervals and a nonsignificant positive association in the third and fourth intervals. Type A/B behavior was positively but not significantly associated with coronary heart disease in the first and third intervals, significantly negatively associated (SRH = 0.70, 95% CI = 0.53-0.93) in the second interval and not associated in the fourth interval. The results confirm the importance of the traditional coronary heart disease risk factors, and raise a substantial question about the importance of Type A/B behavior as a risk factor for coronary heart disease mortality.
Electron Spin Resonance Studies of Anisotropic Ordering , Spin Relaxation , and Slow Tumbling in Liquid Crystalline Solvents

In this work the nonaxial ordering and spin relaxation of PD-Tempone spin probe in several liquid crystalline solvents exhibiting smectic A and B phases were studied utilizing methods previously employed by Polnaszek and Freed for the study of nematic liquid crystals. The results rleported here for the isotropic and nematic phases are generally in accord with those obtained previously. An analysis of isotropic hyperfine shifts, changes in the ordering tensor, and anomalous relaxation behavior in the smectic phases suggest a model in which the PD-tempone probes are partially expelled from the dipolar region of the liquid crystalline molecules toward the more flexible hydrocarbon end chains as a result of the packing of the smetic layers, and concomitantly the probes increasingly experience a slowly relaxing local structure (SRLS) in a cavity-like location. Differences in observations from different types of smectic liquid crystals are interpreted in terms of their differing structures based on X-ray studies. It is shown that the angular dependent line widths in the smectic phases are significantly affected by the size and shape of the sample. These inhomogeneous broadening effects are discussed in detail in terms of static distortions of the smectic layering induced by wall effects and magnetic-field induced torques, and are in reasonable agreement with predictions of a simple model. The residual homogeneous widths are discussed in terms of combined models of anisotropic rotation and anisotropic viscosity as well as associated SRLS models. For the former case, the problem of defining the rotational diffusion tensor, which must be time dependent in any axis system, is discussed in some detail.
A Compositive Diagnosis Method on Turbine-Generator Rotor Winding Inter-turn Short Circuit Fault

Generator vibration characteristic and electric characteristic are analyzed when the rotor winding inter-turn short circuit fault has happened. First, the generator parameters of air-gap magnetomotive force, air-gap magnetic permeability and magnetic flux density on the fault are calculated, and the frequency characteristic of imbalance pull acting on rotor and that of pulsating magnetic pull acting on stator core are analyzed, then the rotor and stator radial vibration characteristics are gotten, which are that rotor vibration of fundamental frequency will increase, and stator vibration of second power frequency will decrease for one pair of poles generator. Next, the electric characteristic is analyzed, which is that the second harmonics circulating current between the stator winding parallel branches will increase when the fault occurs. Synthetically considering the vibration and circulating current characteristics, a method of the rotor winding inter-turn short circuit fault diagnosis, based on compositive characteristics of generator vibration and stator current, is developed. Finally, the vibration and circulating current of a type SDF-9 generator is measured in the laboratory to verify the theoretical analysis presented above.
Purification of argon from a diluted stream

We report on the design, performance and commissioning of a cryogenic distillation column for low radioactivity underground argon purification that has been constructed at Fermi National Accelerator Laboratory. The plant accepts a mixture of argon, helium, and nitrogen with low argon concentration and is designed to return pure argon with a nitrogen contamination less than 10 ppm. During the commissioning, the distillation column in a continuous mode produced argon 99.9% pure. After running in batch mode, the argon purity was increased to 99.95%, with 500 ppm of nitrogen remaining. The argon production rate was about 1 kg/day.
Severe brachial plexus palsy in women without shoulder dystocia.

To the Editor: Reviewing neonatal intensive care unit (NICU) records to identify cases of neonatal brachial plexus injury, Torki et al concluded “severe brachial plexus palsy occurs in women without shoulder dystocia. ” Several concerns exist regarding this conclusion, including the authors’ definition of injury severity, reliance upon medical documentation, and limited follow-up duration. The severity of neonatal brachial plexus injury predicates upon factors unrelated to NICU admission, including the degree of structural damage and neurologic deficit. Higher neonatal brachial plexus injury severity corresponds to greater neuronal damage with functional impairment. Additionally, severe neonatal brachial plexus injuries exhibit lower propensity for spontaneous neural regeneration. While nearly two thirds of infants with mild neonatal brachial plexus injury exhibit functional recovery by 6 months of age, only 14% of those with substantial deficits recover function. Published reviews reflecting obstetric and surgical perspectives base neonatal brachial plexus injury severity on multiplicity of nerves involved, degree of functional impairment, and permanence of deficits. Focusing unilaterally on NICU admission and omitting descriptions of neurologic deficits, Torki et al provide a misleading and incomplete depiction of neonatal brachial plexus injury severity. Relying upon medical records and delivery summaries, Torki et al discounted the possibility of unrecognized or undocumented shoulder dystocia in their series of neonatal brachial plexus injury cases. However, the conclusion that an event did not occur based on absent documentation lacks scientific corroboration. Furthermore, the limited follow-up period raises questions regarding the accurate diagnosis of study participants. Experience in our specialty clinic reveals multiple cases in which the initial diagnosis of neonatal brachial plexus injury required modification based on further scrutiny.
The Tenacity of The Frontal Sinus Mucosa

A number of persons in other surgical disciplines express a blatant disregard for the potential dangers of frontal sinus mucosal entrapment. Although bone removal is universally recommended by the otolaryngologic proponents of ablative procedures in the frontal sinus, no comprehensive explanation has been proffered to justify this dictum. To this end, 27 cats had simple excision of the frontal sinus mucosa to see if it is necessary to bur away the inner table of bone to completely eliminate all vestiges of mucosa. Mucosal regrowth was seen in 72%, and suppurative infection, in 17% of the sinuses. Burring away of the frontal sinus inner table must then be considered as an essential part of any ablative procedure of the frontal sinus.
First Molecular Characterization of Cryptosporidium spp. Infecting Buffalo Calves in Brazil

With the aim of determining the occurrence of Cryptosporidium spp. , 222 fecal samples were collected from Murrah buffalo calves aged up to 6 mo. Fecal DNA was genotyped with a nested polymerase chain reaction targeting the 18S rRNA gene and sequencing of the amplified fragment. Nested 18S PCR was positive for 48.2% of the samples. Sequence analysis showed that the most frequent species in these animals was Cryptosporidium ryanae, which was present in buffalo calves as young as 5 d. The zoonotic species Cryptosporidium parvum was detected in one animal. An uncommon Cryptosporidium 18S genotype was found in buffaloes.
3D manipulation of single cells using dielectrophoretic probe array

Three dimensional (3D) single cell manipulation plays a critical role in the development of cell engineering. Cell manipulation techniques are potentially applied to reconstruct in vitro modeled cells. Our aim is to develop a dielectrophoretic (DEP) probe array for parallel 3D manipulation of single cells. This paper reports fabrication and evaluation of DEP probe array. We fabricated the 3D probe array with electrical connection to the tips. Single cells were collected from a 3D space and trapped on the probe tips. The cells were released from the tips in a parallel manner.
Comparison of Technical and Physiological Characteristics of Prepubescent Soccer Players of Different Ages

Fernandez-Gonzalo, R, De Souza-Teixeira, F, Bresciani, G, García-López, D, Hernández-Murúa, JA, Jiménez-Jiménez, R, and De Paz, JA. Comparison of technical and physiological characteristics of prepubescent soccer players of different ages. J Strength Cond Res 24(7): 1790-1798, 2010-Although soccer is one of the most widely played sports around the world, studies about young players and the success factors in soccer are still scarce. Therefore, the purpose of this study was to offer some insight into the factors contributing to success in this sport and to describe how physiological and technical performance evolves in young soccer players. Soccer technical skills during match play, maximum voluntary isometric contraction and power of lower limbs, jumping ability and endurance parameters were assessed in 30 prepubescent male soccer players with the same experience in soccer training. Subjects were divided into 2 groups of 15 children, a younger group (YG), aged 9.4 ± 0.3 years, and an older group (OG), aged 11.8 ± 0.2 years. Correlations between technical and physiological parameters were also described. Significant difference was set at p < 0.05. Differences between YG and OG appeared in physiological performance, mainly in &OV0312;o2peak expressed in absolute values, &OV0312;o2 at different speeds, perceived exertion in treadmill test, jump performance, strength, and peak power of lower limbs. Among the technical skills measured, significant differences were found only in heading. The differences found between groups showed that most physical capacities that were measured here have an important increase during the first stages of puberty, pointing out that a specific training at these ages is necessary to get an appropriate basis for future performance. Besides, over 30% of the technical performance measured in this study can be explained with the physiological parameters. The data shown in this paper help to determine the most important capacities in youth soccer, which can facilitate the development of more appropriate selection models and trainings.
A Single-Stage PFM-APWM Hybrid Modulated Soft-Switched Converter With Low Bus Voltage for High-Power LED Lighting Applications

In order to design a high-efficiency cost-effective high-power LED driver, a single-stage integrated boost- LLC-type soft-switched ac–dc converter is usually employed. The minimized number of semiconductors and the reduced power loss are its main advantages. However, the high bus voltage is its well-known disadvantage, which is caused by the employment of a conventional pulse frequency modulation (PFM) control strategy with the duty cycle of 0.5. The range of the input ac voltage is severely limited. In order to overcome this problem, a hybrid PFM-asymmetric pulse width modulation strategy is proposed in this paper. The proposed strategy can significantly reduce the bus voltage while maintaining the soft-switching operation for both primary MOSFETs and secondary diodes. Furthermore, the electrolytic capacitors are removed by increasing the bus voltage ripple. Hence, high efficiency, long lifetime, low cost, and universal operation are achieved on the proposed LED driver, which is well matched to the virtues of LED lighting source. The detailed operation principles and design consideration for the proposed modulation approach are analyzed and discussed. The feature of the proposed solution was demonstrated using a universal-input 100-W hardware prototype. The experimental results verified the full-range zero-voltage-switching (ZVS) operation for primary switches and the efficiency achieved 91.6% under the 130-V input voltage.
Analysis of the cardiovascular risk profile in stable kidney transplant recipients after 50% cyclosporine reduction *

Abstract: Background: Long‐term use of cyclosporine (CsA) contributes to post‐transplant cardiovascular disease (CVD). Hence, a reduction in CsA dosage in kidney transplant recipients (KTR) may improve long‐term outcomes. We analyzed the effects of 50% CsA dose reduction on the CVD risk profile in stable KTR.
Speed control of a dc series motor using Buck-Boost converter

This paper presents a Buck-Boost converter using a MOSFET as a switch fed a dc series motor. The characteristics for step - up and down of the output voltage are studied. It is found that this system posses a good operation performance with a minimum ripple in the output of the motor current and voltage. The mathematical models describing both the open and closed-loop systems are proposed using the differential equations describing the system in different modes of operation for open and closed loop systems. The steady-state, starting-up and transient operating conditions are investigated for the open loop system. For the closed loop system, a positive step change in the load is investigated. Also, the effect of positive and negative step changes in the reference voltage are studied.
A 65 nm Ultra-High-Density Dual-Port SRAM with 0.71um/sup ~/ 8T-Cell for SoC

We propose a new access scheme of synchronous dual-port (DP) SRAM that minimizes area of 8T-DP-cell and keeps cell stability. A priority row decoder circuit and shifted bit-line access scheme eliminates access conflict problem. Using 65nm CMOS technology (hp90), we fabricated 32KB DP-SRAM macros with the proposed scheme. We obtain 0.71mum2 8T-DP-cell, which cell size is 1.44times larger than 6T-single-port (SP) cell
Motavizumab Treatment of Infants Hospitalized With Respiratory Syncytial Virus Infection Does Not Decrease Viral Load or Severity of Illness

Background: This study was conducted to determine whether treatment with motavizumab, an anti-respiratory syncytial virus (RSV) monoclonal antibody, would decrease viral load and improve clinical outcomes in previously healthy term infants hospitalized with RSV lower respiratory tract infection. Methods: Infants hospitalized with lower respiratory tract infection and a positive RSV test performed locally were randomized to receive 1 intravenous dose of motavizumab (30 or 100 mg/kg) or placebo. Nasal wash samples were tested by real-time reverse transcriptase polymerase chain reaction at a central laboratory to determine viral load. Clinical data were collected during RSV hospitalization and at 12-month follow up. Results: Of 118 infants, 112 were confirmed RSV positive by real-time reverse transcriptase polymerase chain reaction. In each study group, median (range) RSV load (log10 copies/mL) decreased at a similar rate from baseline to study day 7 [motavizumab 30 mg/kg: 8.35 (2.5–9.5) to 5.03 (2.5–6.8); motavizumab 100 mg/kg: 8.22 (5.5–9.7) to 4.25 (2.5–8.0); placebo: 8.02 (6.7–9.8) to 5.17 (2.5–7.3)]. Median (range) duration of hospitalization was 3.05 (0.8–16.0), 2.99 (1.0–25.0) and 2.88 (0.8–11.7) days for the motavizumab 30 mg/kg, motavizumab 100 mg/kg and placebo groups, respectively. Six (8%) motavizumab and 0 placebo recipients were admitted to the intensive care unit and 4 required mechanical ventilation. The incidence of wheezing episodes during the 12-month follow up was comparable for all 3 groups. Conclusions: Motavizumab had no appreciable effect on RSV viral load measured in the upper respiratory tract of children hospitalized for RSV lower respiratory tract infection. No differences were observed for duration of hospitalization, severity of illness measures or wheezing episodes during 12-month follow up in children treated with motavizumab or placebo.
Systèmes disperses pour l'administration orale de paclitaxel à base de microemulsion et de nanocapsules mucoadhesives contenant de l'huile de copaïba

La voie orale suscite un interet pour l'administration des medicaments anticancereux, qui sont encore administres essentiellement par voie parenterale. En effet, la biodisponibilite des principes actifs est fortement limitee par leurs proprietes physico-chimiques et des facteurs physiologiques. L'utilisation de systemes a base de lipides et de nanoparticules polymeres peuvent se montrer tres performants pour surmonter certaines limitations. L'objectif de ce travail a consiste a developper deux familles de systemes disperses pour la voie orale contenant dans leur phase interne de l'huile de copaiba servant de vehicules a des medicaments anticancereux comme le paclitaxel. Dans la premiere partie du travail a ete consacree au developpement et a la validation de methodes d’analyses de l’huile de copaiba par chromatographie en phase gaseuse et de dosage du paclitaxel dans l'huile de copaiba. Dans la deuxieme partie du travail, des microemulsions d'huile de copaiba/eau ont ete formulee en proposant une approche originale basee sur la complementarite chimique des composes de l'huile et des tensioactifs. Cette approche a permis l'obtention de microemulsion contenant des fractions volumiques importantes de l'huile essentielle de copaiba (19.6%) tout en maintenant les concentrations en tensioactifs faible (13.7%). Du paclitaxel a pu etre incorpore dans les microemulsions sans perturber notablement les caracteristiques du system. La troisieme partie du travail a ete consacre au developpement de nanocapsules mucoadhesives contenant de l'huile de copaiba. La mise en œuvre d’un plan d’experience a contribue a la formulation de nanocapsules incorporant du paclitaxel pouvant etre marquee par une sonde fluorescente. La stabilite des nanocapsules a ete etudiee dans des milieux gastrique et intestinaux simules. Leur mucoadhesion a ete evaluee sur des fragments de muqueuse intestinale preleves chez le rat. Les resultats de ces travaux ont conduit au developpement de deux formulations de paclitaxel dans des nanosystemes originaux qui pourront par la suite etre evalues pour en etudier leur capacite a delivrer l'agent anticancereux par voie orale.