Miracle-dz/UniFAR-FTUs huggingface dataset:
Economic Value of Life in Iran: The Human Capital Approach

Background: The human life value is among the most important challenges of the health economic evaluation. This limitation has reduced the feasibility of applying the cost-benefit method in evaluations of health interventions and policies. Using the human capital approach and discounted value of future earnings, the present study calculated the human capital of different age groups. Methods: The required data were obtained using “income and expenditures of Iranian households” data in 2015 from the Statistical Center of Iran, which included the information on 19380 urban households. Results: According to the calculation of human capital, the maximum value of a statistical life year in the high-income group was related to the age group of 30–34 yr old (223,286 US$ equals to 9378 million Iranian Rials). The lowest value in all three groups of high, medium and low income is related to the age group of 85 and older. In addition, the economic value of statistical life year for men has been calculated as higher than that of women, however, in older age groups, the human capital of both genders have been converging. Conclusion: The economic value of life for young people aged between 20 to 30 yr was higher than other demographic groups. The findings of the research help to provide a more accurate base for the cost-benefit analysis of health and social policies. Considering the economic value of the statistical life for different age groups may change policy priorities in areas related to health and life of human beings.
The Impact of Financial and Non-Financial Work Incentives on the Safety Behavior of Heavy Truck Drivers

The goal of the research is to determine how compensation affects the safety behavior of truck drivers and consequently the frequency of traffic accidents. For this purpose, a survey was conducted on a sample of 220 truck drivers in international road transport in the EU, where the results of the Structural Equation Model (SEM) show that in the current state of the transport sector, financial and non-financial incentives have a positive impact on the work and safety behavior of drivers. Financial incentives also have an impact on drivers’ increased perception of their driving ability, while moving violations continue to have a major impact on the number of accidents. The proposed improvements enable decision-makers at the highest level to adopt legal solutions to help manage the issues that have been affecting the industry from a work, social and safety point of view for the past several years. The results of the research therefore represent an important guideline for improvements to the legislature as well as in the systematization of truck driver compensation within companies.
Immunomodulatory and Antioxidant Activities of Select Indonesian Vegetables, Herbs, and Spices on Human Lymphocytes

Edible plants have attracted increasing attention as functional foods as they are rich in bioactive compounds with health benefits, including antioxidant and immunomodulatory activities. However, scientific evidence of these health effects is limited. This study is aimed at determining antioxidant and immunomodulatory activities of 25 select vegetables, herbs, and spices commonly consumed in Indonesia. Phytochemical profiles were determined by measuring total flavonoid content and 1H-NMR. Human blood lymphocyte cells were used to probe the immunomodulatory potency and treated with the methanol extract of these vegetables, herbs, and spices. The results showed the enhanced propensity for all tested plant extracts to stimulate lymphocyte proliferation, except Pandanus amaryllifolius. Etlingera elatior, Ocimum xcitriodorum, Kaempferia galanga, and Apium graveolens had the highest lymphocyte cell proliferation stimulation index (SI) at concentrations of 41.67, 16.67, 4.17, and 2.5 mg/mL culture, respectively (SI 2.21 ± 0.05, 2.62 ± 0.12, 3 ± 0.05, and 2.64 ± 0.07, respectively). The NMR spectra of these four most potent plants showed low peaks in the aromatic/phenolic area and several other peaks indicating the presence of terpenoid, steroid, amino acid, and sugar compounds. The results demonstrate the immunomodulatory potential of all vegetables, herbs, and spices, except P. amaryllifolius, although this potential did not necessarily correlate with flavonoid content and antioxidant activity. Nevertheless, this research showed promising health effect, particularly immunomodulation, of the various local plants. Further elaboration on the specific immunomodulatory activity will be interesting.
Stability enhancement of lycopene in Citrullus lanatus extract via nanostructured lipid carriers

Abstract Lycopene is one of naturally occurring carotenoids in plants including watermelon (Citrullus lanatus). Heat, light, and oxygen effect on lycopene isomerization and degradation. Nanostructured lipid carriers (NLCs) are drug delivery system which can enhance the stability of active compound. Therefore, this study aimed to develop watermelon extract loaded in NLCs for lycopene stability improvement. The NLCs were prepared using a hot homogenization technique. Cocoa butter was used as solid lipid. Grape seed oil was used as liquid lipid. Span® 80 and Plantasens® HE20 were used as an emulsifier. The selected unloaded NLCs contained solid lipid to liquid lipid at the ratio of 3:1 and 10% (w/w) of total lipid. The particle size of watermelon extract‐loaded NLCs (WH‐loaded NLCs) was 130.17 ± 0.72 nm with low PDI and high zeta potential. It also presented high entrapment efficiency. For stability study, the WH‐NLC3 could enhance stability and maintain lycopene content after stability test. It exhibited the highest values of lycopene content (83.26 ± 2.30%) when stored at 4°C. It also possessed a prolonged release pattern over 48 hr. Therefore, the NLCs could improve stability and release profile of lycopene from watermelon extract.
IDTWO: A Protocol for a Randomised Controlled Trial of a Web-Based Mental Health Intervention for Australians with Intellectual Disability

People with intellectual disability (ID) experience higher rates of mental illness and reduced access to appropriate care and treatment. Tailored electronic mental health (eMH) programs offer opportunities to address these disparities. The aim of this study is to examine whether a fully automated and self-guided eMH program tailored to the needs of people with ID can reduce symptoms of anxiety and depression and improve daily functioning in people with borderline-to-mild ID. Australians with borderline-to-mild ID, aged 16 years and older with mild-to-moderate depression and/or anxiety symptoms will be eligible to participate with the help of a nominated carer, if necessary. A randomised controlled trial with a sample size of 150 participants divided into treatment and waitlist control arms will be conducted. Participants randomised to the intervention group will have full access to the Healthy Mind program for eight weeks. The waitlist control group will gain full access to the program following the eight-week treatment period. Efficacy will be assessed on the Anxiety, Depression, and Mood Scale; Kessler-10; and the World Health Organisation Disability Assessment Schedule 2.0 across three time-points (baseline, eight weeks, and three months). We expect that people who use the intervention will report reduced depression and anxiety, relative to the control group. To our knowledge, this is the first study to examine the effectiveness of a fully automated eMH program for improving mental health in people with ID. We expect our study to render new knowledge on the delivery and effects of internet-based cognitive behaviour therapy (CBT) tools for people with ID.
BEHAVIOUR OF ANTIMONY AND BISMUTH IN COPPER ELECTROREFINING CIRCUITS

Abstract Antimony- and bismuth-rich copper anodes, anode slimes and decopperized anode slimes from industrial copper electrorefineries were studied mineralogically. Antimony in the anodes occurs mainly as Cu-Pb-As-Sb-Bi oxide inclusions along the copper grain boundaries; bismuth is mainly present as Cu-Pb-As-Sb-Bi oxide, Cu-Bi-As oxide, Cu-Pb-As-Bi oxide and Cu-Bi oxide inclusions. Sb and Bi partly dissolve during electrorefining, but extensively reprecipitate as As-Sb oxide, As-Sb-Bi oxide and SbAsO4. The presence of As results in the precipitation of essentially all the Bi as BiAsO4. The decopperizing process dissolves much of the Sb and Bi, although the majority of the BiAsO4 phase remains unaffected. Subsequently, some of the dissolved Sb and Bi reprecipitates as various oxide, sulphate and arsenate species. X-ray absorption near-edge structure (XANES) analyses suggest about 70% of the antimony in the anode slimes is present in the pentavalent oxidation state. The XANES analyses indicate that most of the Bi in all the slimes samples is present in the trivalent oxidation state. On a étudié minéralogiquement les anodes de cuivre riches en antimoine et en bismuth, les boues de l’anode et les boues décuivrées de l’anode provenant d’usines industrielles d’affinage électrolytique du cuivre. L’antimoine des anodes se trouve principalement sous forme d’inclusions d’oxyde de Cu-Pb-As-Sb-Bi le long des joints de grain du cuivre; le bismuth est présent principalement comme inclusions d’oxyde de Cu-Pb-As-Sb-Bi, de Cu-Bi-As, de Cu-Pb-As-Bi et de Cu-Bi. Sb et Bi sont partiellement dissous lors de l’affinage électrolytique, mais se re-précipitent en grande quantité sous forme d’oxyde d’As-Sb, d’oxyde d’As-Sb-Bi et de SbAsO4. La présence d’As aboutit à la précipitation d’essentiellement tout le Bi sous forme de BiAsO4. Le procédé de décuivrage dissout presque tout le Sb et le Bi, bien que la majorité de la phase BiAsO4 reste inaffectée. Subséquemment, une certaine partie du Sb et du Bi dissous se re-précipite sous diverses espèces d’oxyde, de sulfate et d’arséniate. Des analyses de structure périphérique par absorption des rayons x (XANES) suggèrent qu’environ 70% de l’antimoine dans les boues de l’anode est présent à l’état d’oxydation pentavalente. Les analyses de XANES indiquent que presque tout le Bi dans tous les échantillons de boues est présent à l’état d’oxydation trivalente.
A Realistic Predictor for Pedestrian Attribute Recognition

The application of video surveillance systems in public areas to ensure public security is becoming increasingly important. A major task when evaluating the arising amount of video data is to ﬁnd the occurrences of a person-of-interest on the basis of a testimony. For the comparison of a person’s description with persons in the video data, the attributes of all persons must be recognized automatically. However, typical approaches to pedestrian attribute recognition simply predict all attributes for a person, regardless the visibility of relevant attributes. To address this problem, the concept of realistic predictors is used in this work to determine and improve the reliability of pedestrian attribute recognition.
Evidence of Epstein–Barr Virus in Female Breast Cancer

1. Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran 2. Infectious and Tropical Diseases Research Center, Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran 3. Department of Microbiology & Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran 4. Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran 5. Department of Pathobiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Influence of Relative Displacement on Surface Roughness in Longitudinal Turning of X37CrMoV5-1 Steel

The shaping process of surface texture is complicated and depends on many factors and phenomena accompanying them. This article presents the author’s test stand for the measurement of relative displacements in a tool–workpiece system during longitudinal turning. The aim of this study was to determine the influence of edge radius on the relative displacement between the tool and workpiece. The cutting process was carried out with inserts with different edge radii for X37CrMoV5-1 steel. As a result of the research, vibration charts of the tool–workpiece system were obtained. In the range of feed 0.03–0.18 mm/rev, the values of the standard deviation of relative displacements in the x-axis were obtained in the range of 0.36–0.78 μm for the insert with an edge radius of rn = 48.8 μm. As a result of the work, it was determined that for the feed value of 0.12 mm/rev for all inserts, the relative displacements are the smallest. As the final effect, the formula for forecasting the Ra roughness parameter was presented.
Comparison of Early-Stage Mothers and Childless Women Seeking Pregnancy: Experienced Stress, Resilience and Satisfaction with Relationship with the Partner

Introduction: The birth of a child is a significant turning point in the life of a woman. It is a source of personal fulfilment, but also a great challenge. On the other hand, the inability to conceive a child in a natural way results in a serious distortion of a woman’s psychic balance. Becoming a mother is an indicator of personal fulfilment and the source of social acceptation. Therefore, both becoming a mother and the inability to conceive a child in a natural way may be seen as stressful factors that impact a woman’s life. Aim of the study: The research project aimed to analyze the differences in stress, resilience and satisfaction with relationship and sexual satisfaction between early-stage mothers, i.e., women having a child and childless women seeking pregnancy. Sample: The study involved 80 women—40 mothers and 40 infertile women. The mean age of the mothers was 31.10 yrs (SD = 3.76) and of the childless women seeking pregnancy—31.48 yrs (SD = 3.35). Both groups were homogenous with regards to education, place of residence, the form and time of their relationship with partners. Method: The perceived stress was measured with the Perceived Stress Scale PSS—Polish adaptation by Juczyński and Ogińska-Bulik. Resilience was measured with Personal Adaptation Scale (LIRS-pl)—Polish adaptation by Malina, Pooley and Harms. The quality of the relationship was measured using the Quality of Relationship Inventory (QRI) adapted to Polish version by Suwalska-Barancewicz, Liberska and Izdebski and the sexual satisfaction was measured with the Sexual Satisfaction Questionnaire by Nomejko and Dolińska-Zygmunt. Results and conclusions: Statistical analyses indicate that the participating women differ in the level of perceived stress (higher among childless women seeking pregnancy; t = 2.721; p = 0.008), the depth/intensity of the relationship (higher among childless women seeking pregnancy; t = 2.376; p = 0.020) and conflict (higher among mothers; t = −2.829; p = 0.006). This research project proved that infertility and its consequences are not only negative. The research has shown that lower levels of relationship conflicts and greater commitment occur more frequently among infertile women than among mothers. Regardless of the observed differences in the studied sample, it is noteworthy that the compared groups are also similar to some extent. They neither differed in the level of personal resilience nor perceived support. Therefore, although the two experienced issues seem to be different, they may appear psychologically similar to some extent.
Ethyl acetate subfractions from ethanol extracts of fermented oats (Avena sativa L.) exert anti-cancer properties in vitro and in vivo through G2/M and S Phase arrest and apoptosis

Background: Cancer is a major public problem and poses a long-term impact on patients' life, work, and study. Oats are widely recognized as healthy food and fermented oats were rich in the higher contents of polyphenols. However, the role of fermented oats in cancer remains elusive. Methods: The effect of ethyl acetate subfractions (EASs) from ethanol extracts of oats fermented by Rhizopus oryzae 3.2751 on cancer cells was verified by series experiments in vitro and in vivo. The cell viability, colony formation, cell cycle, apoptosis, reactive oxygen species (ROS), mitochondrial membrane potential (MMP), and western blot were determined in vitro. The toxicity of EASs and xenograft mouse model were performed in vivo. Results: MTT assay indicated that EASs interference suppressed the proliferation of four human cancer cells in a dose-dependent manner without a significant impact on two normal cells. EASs (0.2, 0.4, and 0.8 μg/mL) resulted in the G2/M and S phase arrest, apoptosis, depolarization of MMP, and ROS generation in HepG2 cells by flow cytometry. p53, JNK, caspase-9, and caspase-3 were activated and the expression of Bax was promoted, while the expression of Bcl-2 was reduced in HepG2 cells exposed to EASs via western blot. Furthermore, the in vivo study using a xenograft mouse model demonstrated that EASs attenuated the tumor growth with low systemic toxicity. Conclusions: EASs exhibited anti-cancer activities in vitro and in vivo via cell cycle arrest and apoptosis. This finding suggests that polyphenol-enriched composition from fermented oats might become a promising candidate for impeding the development and progression of liver cancer.
FGF19/SOCE/NFATc2 signaling circuit facilitates the self-renewal of liver cancer stem cells

Background & Aims: Liver cancer stem cells (LCSCs) mediate therapeutic resistance and correlate with poor outcomes in patients with hepatocellular carcinoma (HCC). Fibroblast growth factor (FGF)-19 is a crucial oncogenic driver gene in HCC and correlates with poor prognosis. However, whether FGF19 signaling regulates the self-renewal of LCSCs is unknown. Methods: LCSCs were enriched by serum-free suspension. Self-renewal of LCSCs were characterized by sphere formation assay, clonogenicity assay, sorafenib resistance assay and tumorigenic potential assays. Ca2+ image was employed to determine the intracellular concentration of Ca2+. Gain- and loss-of function studies were applied to explore the role of FGF19 signaling in the self-renewal of LCSCs. Results: FGF19 was up-regulated in LCSCs, and positively correlated with certain self-renewal related genes in HCC. Silencing FGF19 suppressed self-renewal of LCSCs, whereas overexpressing FGF19 facilitated CSCs-like properties via activation of FGF receptor (FGFR)-4 in none-LCSCs. Mechanistically, FGF19/FGFR4 signaling stimulated store-operated Ca2+ entry (SOCE) through both the PLCγ and ERK1/2 pathways. Subsequently, SOCE-calcineurin signaling promoted the activation and translocation of nuclear factors of activated T cells (NFAT)-c2, which transcriptionally activated the expression of stemness-related genes (e.g., NANOG, OCT4 and SOX2), as well as FGF19. Furthermore, blockade of FGF19/FGFR4-NFATc2 signaling observably suppressed the self-renewal of LCSCs. Conclusions: FGF19/FGFR4 axis promotes the self-renewal of LCSCs via activating SOCE/NFATc2 pathway; in turn, NFATc2 transcriptionally activates FGF19 expression. Targeting this signaling circuit represents a potential strategy for improving the therapeutic efficacy of HCC.
Anti-inflammatory Effects of S. cumini Seed Extract on Gelatinase-B (MMP-9) Regulation against Hyperglycemic Cardiomyocyte Stress

Black berry (Syzygium cumini) fruit is useful in curing diabetic complications; however, its role in diabetes-induced cardiomyopathy is not yet known. In this study, we investigated the regulation of gelatinase-B (MMP-9) by S. cumini methanol seed extract (MSE) in diabetic cardiomyopathy using real-time PCR, RT-PCR, immunocytochemistry, gel diffusion assay, and substrate zymography. The regulatory effects of MSE on NF-κB, TNF-α, and IL-6 were also examined. Identification and estimation of polyphenol constituents present in S. cumini extract were carried out using reverse-phase HPLC. Further, in silico docking studies of identified polyphenols with gelatinase-B were performed to elucidate molecular level interaction in the active site of gelatinase-B. Docking studies showed strong interaction of S. cumini polyphenols with gelatinase-B. Our findings indicate that MSE significantly suppresses gelatinase-B expression and activity in high-glucose- (HG-) stimulated cardiomyopathy. Further, HG-induced activation of NF-κB, TNF-α, and IL-6 was also remarkably reduced by MSE. Our results suggest that S. cumini MSE may be useful as an effective functional food and dietary supplement to regulate HG-induced cardiac stress through gelatinase.
Development of a new workflow for pseudo-component generation of reservoir fluid detailed analysis: a gas condensate case study

In this work, a new automatic workflow for accurate optimal pseudo-component generation from gas condensate mixtures with a large number of components is presented. This workflow has a good insight into thermo-physical and critical properties and introduces only a small amount of loss of information and EOS flexibility. In this regard, the fuzzy clustering is used to classify the components in the mixture based on the similarities in the critical properties. The mixing rules are then applied to find group properties. Two different approaches for components association in clustering process are investigated with several numbers of groups. The mathematical validity of the groups is controlled with a proper validity index. The fluid phase behaviour is analysed to investigate the proposed workflow under physical feedback for different numbers of groups. The comparison of equilibrium calculations, for the extended and grouped mixtures shows a close agreement. The average absolute deviation percent (AAD%) from the extended analysis for the liquid dropout percent in constant volume depletion reaches to 0.32 for 20 groups and 0.93 for 14 groups. The AAD% for the gas compressibility factor over the pressure steps is 0.00 for 20 groups and 0.04 for 14 groups.
DUOX2 As a Potential Prognostic Marker which Promotes Cell Motility and Proliferation in Pancreatic Cancer

DUOX2 has been reported to highly express in several types of cancers. However, the prognostic significance and the biological function of DUOX2 expression with pancreatic cancer (PC) still remain unclear. The present study is aimed at investigating whether DUOX2 could act as a novel biomarker of prognosis and evaluating its effect on PC cell progression. The mRNA and protein expression of DUOX2 in PC cells and tissues were assessed by quantitative real-time PCR (RT-qPCR) and immunohistochemistry. The effect of DUOX2 expression on PC cell motility and proliferation was evaluated in vitro. The correlation between DUOX2 mRNA expression and clinicopathological features and its prognostic significance were analyzed according to the Gene Expression Profiling Interactive Analysis (GEPIA) website based on The Cancer Genome Atlas (TCGA) and the GTEx databases combined with our clinical information. According to bioinformatics analysis, we forecasted the upstream transcription factors (TFs) and microRNA (miRNA) regulatory mechanism of DUOX2 in PC. The expression of DUOX2 at transcriptional and protein level was dramatically increased in PC specimens when compared to adjacent nontumor specimens. Functionally, DUOX2 knockdown inhibited cell motility and proliferation activities. Our clinical data revealed that the patients had better postoperative overall survival (OS) with lower expression of DUOX2, which is consistent with GEPIA data. Multivariate analysis revealed that high DUOX2 expression was considered as an independent prognostic indicator for OS (P = 0.031). Based on Cistrome database, the top 5 TFs of each positively and negatively association with DUOX2 were predicted. hsa-miR-5193 and hsa-miR-1343-3p targeting DUOX2 were forecasted from TargetScan, miRDB, and DIANA-TarBase databases, which were negatively correlated with OS (P = 0.043 and P = 0.0088, respectively) and DUOX2 expression (P = 0.0093 and P = 0.0032, respectively) in PC from TCGA data. These findings suggest that DUOX2 acts as a promising predictive biomarker and an oncogene in PC, which could be a therapeutic target for PC.