Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring Soft Concepts with Hard Corpus-Analytic Methods

: Corpus-analytic studies are currently experiencing a veritable boom in the social sciences. However, three crucial barriers impede the methodological quality and long-term reputation of these promising new technologies: Firstly, creating and pre-processing very large text corpora is still a laborious and costly enterprise. Secondly, the semantically valid operationalization of complex theoretical concepts remains a problem. Thirdly, scholars need flexible data output and visualization options to connect the data generated by computational methods with the discipline’s existing research. We will conclude that it is possible to solve these problems. However, hermeneutically sensitive uses of computational methods will take much more time, work, and creativity than often assumed. The reflected appropriation of big data methods in the social sciences has only just begun.
Resonance Raman Spectroscopy and Electron–Phonon Coupling in Zinc Selenide Quantum Dots

Resonance Raman spectra, including absolute scattering cross sections, depolarization ratios, and overtone to fundamental intensity ratios, have been measured for three sizes of ZnSe quantum dots between 3.8 and 4.9 nm diameter (first excitonic peak maximum at 402–417 nm) using excitation wavelengths between 400 and 425 nm. Spectra were obtained both in cyclohexane solution and in thin films in order to quantitate the exciton–phonon coupling strength. The Raman data and optical absorption spectra were simulated using a particle in a sphere effective mass model for the excitonic transitions similar to that previously employed for CdSe [Lin, C. ; Gong, K. ; Kelley, D. F. ; Kelley, A. M. J. Phys. Chem. C 2015, 119, 7491]. The Huang–Rhys parameter of the longitudinal optical phonon in the lowest excitonic transition is in the range S = 0.3–0.5, about a factor of 2 larger than for CdSe quantum dots of similar size. Smaller ZnSe quantum dots (∼3.0 nm diameter, first excitonic maximum at 379 nm) measured in films s.
Rapid detection of Listeria monocytogenes using fluorescence immunochromatographic assay combined with immunomagnetic separation technique

Summary To ensure the safety and quality of food ingredients, especially meat and dairy products, a high-throughput, rapid and sensitive method to detect Listeria monocytogenes (LM) is always on a high demand. In this work, a specific induction method to enrich and detect LM based on fluorescence immunochromatographic assay (FICA) combined with immunomagnetic separation (IMS) techniques has been developed. The immunomagnetic-beads (IM) beads were obtained through functionalised magnetic microspheres and the conjugated reaction between the carboxyl on beads surface and amino groups of antibody. The prepared IM-beads could be used for rapidly enriching pathogenic bacteria with fewer steps, resulting in a high specificity for four pathogenic serotypes and about a 40-fold improvement of detection limit compared with FICA only. In addition, this method was successfully applied in LM detection in sausage, pork and milk samples with a potential for further application in rapid on-site detection of pathogenic bacteria.
Psicoterapia Centrada en el Sentido: Una revisión acerca de estrategias psicoterapéuticas para el tratamiento del paciente con cáncer

Objetivo: presentar las estrategias psicoterapéuticas utilizadas en el tratamiento de pacientes con cáncer, cuya finalidad sea trabajar el sentido de la vida. Método: Se realizó una revisión sistemática inscrita en el registro PROSPERO con el número CRD42019132385, siguiendo el método PRISMA, en las bases Lilacs, Medline, Scopus y Web of Science. Resultados: Se incluyeron 11 artículos publicados entre 2014 y 2020. La Psicoterapia Centrada en el Sentido (PCS) es la estrategia psicoterapéutica más utilizada y efectiva para ayudar al paciente acerca de su sentido de la vida. Discusión: Se desarrollaron tres categorías: 1. Encontrando el sentido de la vida por medio de la PCS; 2. Bienestar espiritual y psicológico de la PCS y 3. Terapias individuales, grupales y de pareja como estrategias eficaces de la PCS. Conclusiones: Este estudio señala que la PCS, además de ser beneficioso para los pacientes, puede servir como una alternativa de trabajo para el psicólogo principalmente en regiones de habla portuguesa donde no se encontraron estudios.
Evaluation of a mobile application tool (BiliNorm) to improve care for newborns with hyperbilirubinemia in Indonesia

Background Severe hyperbilirubinemia is more frequent in low- and middle-income countries such as Indonesia than in high-income countries. One of the contributing factors might be the lack of adherence to existing guidelines on the diagnosis and treatment of hyperbilirubinemia. We developed a new national guideline for hyperbilirubinemia management in Indonesia. To help healthcare workers use this guideline, a web-based decision support tool application may improve both the adherence to the guideline and the care for infants with hyperbilirubinemia. Methods We developed a web-based application (BiliNorm) to be used on a smartphone that displays the bilirubin level of the patient on the nomogram and advises about the treatment that should be started. Healthcare workers of two teaching hospitals in East Java, Indonesia, were trained on the use of BiliNorm. At 6 months after the introduction, a questionnaire was sent to those who worked with the application enquiring about their experiences. An observational study was conducted in two time epochs. A chart review of infants with hyperbilirubinemia in the two hospitals was sent. The appropriateness of hyperbilirubinemia management during a 6-month period before BiliNorm introduction was compared to that during a 7-month period after its introduction. Results A total of 43 participants filled in the questionnaire, the majority (72%) of them indicated that BiliNorm was well received and easy to use. Moreover, 84% indicated that BiliNorm was helpful for the decision to start phototherapy. Chart review of 255 infants before BiliNorm introduction and that of 181 infants after its introduction indicated that significantly more infants had received treatment according to the guideline (38% vs 51%, p = 0.006). Few infants received phototherapy, but bilirubin level was not measured (14% vs 7%, p = 0.024). There was no difference in the proportion of infants who were over- and under-treated (34% vs 32% and 14% vs 10%, respectively). Conclusions The web-based decision tool BiliNorm appears to be a valuable application. It is easy to use for healthcare workers and helps them adhere to the guideline. It improves the care for infants with hyperbilirubinemia and may help reduce the incidence of severe hyperbilirubinemia in Indonesia.
Influence of antimony on structure and physical properties of molten tin

Structure of liquid Sb-Sn alloys were stud-ied by means of viscosity measurements and X-ray dif-fraction. Structural factors and pair correlation functions were analysed and interpreted using the random atomic distribution model. The features of temperature dependence of the viscosity coeﬃcient were analysed taking into account X-ray diﬀraction patterns. The results allow us to conclude that Sb atoms substitute for Sn atoms, forming a typical atomic solution, which reveals chemical and topological short-range order. Moreover, certain atoms form Sb- and Sn-based Sb n Sn m associates and self-associates.
Plastome structure and phylogenetic relationships of Styracaceae (Ericales)

Background The Styracaceae are a woody, dicotyledonous family containing 12 genera and an estimated 160 species. Recent studies have shown that Styrax and Sinojackia are monophyletic, Alniphyllum and Bruinsmia cluster into a clade with an approximately 20-kb inversion in the Large Single-Copy (LSC) region. Halesia and Pterostyrax are not supported as monophyletic, while Melliodendron and Changiostyrax always form sister clades. Perkinsiodendron and Changiostyrax are newly established genera of Styracaceae. However, the phylogenetic relationship of Styracaceae at the generic level needs further research. Results We collected 28 complete plastomes of Styracaceae, including 12 sequences newly reported here and 16 publicly available sequences, comprising 11 of the 12 genera of Styracaceae. All species possessed the typical quadripartite structure of angiosperm plastomes, with sequence differences being minor, except for a large 20-kb (14 genes) inversion found in Alniphyllum and Bruinsmia . Seven coding sequences ( rps4 , rpl23 , accD , rpoC1 , psaA , rpoA and ndhH ) were identified to possess positively selected sites. Phylogenetic reconstructions based on seven data sets (i.e., LSC, SSC, IR, Coding, Non-coding, combination of LSC + SSC and concatenation of LSC + SSC + one IR) produced similar topologies. In our analyses, all genera were strongly supported as monophyletic. Styrax was sister to the remaining genera. Alniphyllum and Bruinsmia form a clade. Halesia diptera does not cluster with Perkinsiodendron , while Perkinsiodendron and Rehderodendron form a clade. Changiostyrax is sister to a clade of Pterostyrax and Sinojackia . Conclusion Overall, our results demonstrate the power of plastid phylogenomics in improving estimates of phylogenetic relationships among genera. This study also provides insight into plastome evolution across Styracaceae.
Designing Shipping Policies with Top-up Options to Qualify for Free Delivery

Motivated by the growing significance of contingent free shipping (CFS) policies in the e-commerce industry, we investigate the optimal CFS and pricing decisions for online retailers. Under a CFS policy, consumers enjoy free shipping for orders exceeding a certain threshold value; otherwise, they are charged a flat fee for orders below this threshold. We adopt a utility-based model to capture consumers’ behavior of purchasing additional items to qualify for free shipping under a CFS policy and analyze its impact on policy structure and consumer surplus. We characterize the retailer’s optimal pricing and CFS policy as functions of consumer mix. When consumer heterogeneity is large enough, the optimal policy induces some consumers to top up and may allow some others to ship for free. In this case, the retailer can charge a high profit margin. Otherwise, a top-up option is unnecessary and a flat-rate shipping fee policy is optimal. Moreover, while the optimal policy never induces all consumers to top up when they are rational, it is possible to do so when consumers associate a psychological disutility with the shipping fee. Surprisingly, the total consumer surplus under the optimal policy may increase in the latter case. Lastly, we show that a subscription program, in addition to the CFS policy, can improve profits when consumers’ order size and frequency are negatively correlated. We find that consumer heterogeneity explains the existence of different forms of shipping policy in reality. The CFS policy is a more effective discrimination mechanism in extracting consumer surplus compared to the flat-rate shipping fee policy. The retailer should utilize the CFS policy especially when consumer heterogeneity is significant. Our findings reveal important insights regarding the impact of consumers’ top-up behavior on a retailer’s optimal operational and marketing decisions.
Plesiomonas shigelloides, a potential pathogen of enteritis in Ictalurus punctatus

Enteritis has resulted in large economic losses in channel catfish aquaculture. Yet only scarce information is available on Plesiomonas shigelloides as a causal agent for this disease. In this study, a virulent strain, temporarily named BD1, was isolated from diseased channel catfish suffering from enteritis, and was identified as P. shigelloides through molecular and phenotypic methods. A phylogenetic tree was also constructed to determine its taxonomic position. In addition, the BD1 isolate has developed multiple resistances to aminoglycosides, amphenicols, quinolones, tetracyclines and sulfonamides drugs for veterinary uses in aquaculture as revealed when screened against a range of common antibiotics. To the best of our knowledge, this is the first report of P. shigelloides as a potential pathogen of enteritis in channel catfish.
Measuring Maintainability of Object Oriented Design (MMOOD)

Measuring maintainability early in the software development life cycle mainly at design phase is a landmark of crucial significance to software designers, developers and quality controllers. Initial Measurement of object oriented software maintainability, absolutely at design phase supports designers to increase their designs before the coding starts. Practitioners and developers repeatedly advocate that maintainability Measurement should be planned at design phase of development life cycle. This paper proposes a Maintainability Measurement Model that works at design phase of system development life cycle. Furthermore, statistical test is performed to justify the correlation of Maintainability with its key contributors Modifiability and Analyzability. The developed model has been authenticated using investigational tryout. In decision, it contains the empirical authentication of the developed maintainability measurement model. KeywordsMaintainability, Object Oriented Metrics, Maintainability Factors, Analyzability, Modifiability, Design Phase, Development life cycle
Fair and Representative Subset Selection from Data Streams

We study the problem of extracting a small subset of representative items from a large data stream. In many data mining and machine learning applications such as social network analysis and recommender systems, this problem can be formulated as maximizing a monotone submodular function subject to a cardinality constraint k. In this work, we consider the setting where data items in the stream belong to one of several disjoint groups and investigate the optimization problem with an additional fairness constraint that limits selection to a given number of items from each group. We then propose efficient algorithms for the fairness-aware variant of the streaming submodular maximization problem. In particular, we first give a -approximation algorithm that requires passes over the stream for any constant ε > 0. Moreover, we give a single-pass streaming algorithm that has the same approximation ratio of when unlimited buffer sizes and post-processing time are permitted, and discuss how to adapt it to more practical settings where the buffer sizes are bounded. Finally, we demonstrate the efficiency and effectiveness of our proposed algorithms on two real-world applications, namely maximum coverage on large graphs and personalized recommendation.
Determination of model parameters (,t2 and R0) for superposition model (SPM) analysis of Ni2+ centres in fluorine crystals

ABSTRACT This study is aimed to determine the superposition model (SPM) parameters, the intrinsic parameter , power law exponent t2 and the reference distance R0, for Ni2+ (3d8) ions in fluorine ligand systems. Various electron paramagnetic resonance (EPR) and crystallographic data of Ni2+ ions in several crystals have been considered. The success of the determined model parameter sets is shown for the investigations of zero-field splitting parameters of various Ni2+ centres with different trigonal, tetragonal and even orthorhombic symmetries. We believe that the SPM parameters proposed here may serve as resource to theoretical investigations of Ni2+ centres in related crystals.
Migration of plastic packaging light stabilizers into food simulators : their reactivity in unsaturated fatty esters

Les emballages plastiques sont habituellement stabilises contre les effets de la lumiere par des amines a encombrement sterique (HALS) derivees de la piperidine, et par des absorbeurs d'UV (UV A). Les stabilisants amines peuvent reagir avec les groupements oxygenes pour former des radicaux aminoxyle stables (NO o ) specifiquement detectes par Resonance Paramagnetique Electronique. La formation de ces NO° a ete mise en evidence apres ionisation de formulations de polypropylene dopees en HALS et en UVA du type benzotriazole. Il sont issus de la reaction des stabilisants avec les radicaux peroxyles (POO o ) induits par radiolyse dans le materiau
Tumour Microbiome-Based Subtypes of Colorectal Cancer Correlate with Clinical Variables

BackgroundLong-term dysbiosis of the gut microbiome has a significant impact on the development, progression and the aggressiveness of colorectal cancer (CRC) and may explain part of the observed heterogeneity of the disease from phenotypic, prognostic and response to treatment perspectives. Although the shifts in gut microbiome in the normal-adenoma-carcinoma sequence have been described, the landscape of microbiome within CRC and its associations with clinical variables remain under-explored. ResultsWe performed 16S rRNA gene sequencing of paired tumour tissue, adjacent visually-normal mucosa and stool swabs of N=186 patients with stage 0-IV CRC to describe the tumour microbiome and its association with clinical variable and to derive tumour microbial subtypes.We identified new genera never previously associated with CRC tumour mucosa (Flavonifractor, Haemophilus, Howardella, Pseudomonas, Sutterella, Treponema 2) or CRC (Actinobacillus, Aggregatibacter, Bergeyella, Phocaeiola, Defluviitaleaceae UCG-011, Massilia, Tyzzerella 4). The bacteria residing on tumour-mucosa were dominated by genera belonging to (potential) oral pathogens. Based on tumour microbial profiles, we stratified CRC patients into three subtypes. The subtypes were significantly associated with prognostic factors such as tumor grade, primary tumour sidedness and TNM staging, with one subtype enriched in tumours with poor prognosis. Further, we inspected the associations of microbiome with clinical variables in a subtype-agnostic setting. The primary tumour-associated clinical variables predominantly correlated with tumour mucosal microbiome, while the presence of local and distant metastases was mostly associated with the stool microbiome.ConclusionsUnderstanding the interactions of the bacteria residing on tumour mucosa within different CRC tumour microbiome subtypes will help to better understand the underlying biological background of the heterogeneity of this disease. Indeed, the tumour microbiome is a possible source of additional integrative markers of CRC patients’ survival and prognosis. We found that CRC microbiome is strongly correlated with clinical variables, but these associations are dependent on the microbial environment (tumour mucosa, normal mucosa, stool). Our study thus identifies limitations of the usage of microbiome composition as marker of CRC progression, suggesting the need of combining several sampling sites (e.g. stool and tumour swabs).
Rancang Bangun Simulasi Quadrature Phase Shift Keying (QPSK) Berbasis Graphical User Interface (GUI)

Modulasi QPSK (Quadrature Phase Shift Keying) adalah teknik modulasi digital yang merupakan pengembangan dari modulasi PSK (Phase Shift Keying) dengan memanfaatkan perubahan fasa dari sinyal pembawa.Modulasi PSK dapat mengkodekan dua bit per simbol yang ditujukan untuk meminimalkan bit eror rate (BER). Pada penelitian ini bertujuan untuk membuat aplikasi sederhana menggunakan matlab berbasis GUI untuk memodulasi sinyal biner QPSK. Metode yang dilakukan dalam pembuatan aplikasi dimulai dari tahap perancangan system, tahap coding, desain interface dan tahap pengujian. Aplikasi sederhana yang dirancang sudah berjalan dengan baik dan sesuai dengan teori yang ada dengan beberapa fitur didalamnya yaitu terdapat tombol random berfungsi untuk mengacak angka biner secara otomatis. Kemudian tombol start berfungsi untuk menampilkan sinyal modulator, demodulator, dan sinyal termodulasi atau sinyal QPSK dan sebaran konstelasi diagramnya.Kata kunci: Demodulator, Modulator, GUI, QPSK, Simulasi
Empirical Analysis of the External Determinants of the Budget Deficit:Case of Morocco

This work aims to examine the effect of external variables on the budget balance in Morocco using annual data for the period (1980-2016). The empirical results of the estimation of the VAR model show that the external variables have direct and indirect effects on the budget balance. A positive oil price shock does not have a significant influence on the budget balance in the short term. But, its indirect long-term effect is significant. Furthermore, a positive shock to the real effective exchange rate generates a widening budget deficit. The degree of trade openness has a positive effect on the fiscal balance in the short and long term.
Polyethylene Glycol-mediated Transformation of Drechmeria coniospora

[Abstract] Drechmeria coniospora is a nematophagous fungus and potential biocontrol agent. It belongs to the Ascomycota. It is related to Hirsutella minnesotensis, another nematophagous fungus but, phylogenetically, it is currently closest to the truffle parasite Tolypocladium ophioglossoides. Together with its natural host, Caenorhabditis elegans, it is used to study host-pathogen interactions. Here, we report a polyethylene glycol-mediated transformation method (Turgeon et al., 2010; Ochman et al., 1988) for this fungus. The protocol can be used to generate both knock-in or knock-out strains (Lebrigand et al., 2016).
Rational Design, Synthesis, and In-Silico Evaluation of Homologous Local Anesthetic Compounds as TASK-1 Channel Blockers

Advances in different technological and scientific fields have led to the development of tools that allow the design of drugs in a rational way, using defined therapeutic targets, and through simulations that offer a molecular view of the ligand–receptor interactions, giving precise information for the design and synthesis of new compounds. Ion channels are of great relevance as therapeutic targets since they play roles in different pathologies. Several ion channels are expressed in the atria and constitute a therapeutic target for the treatment of atrial fibrillation (AF), the most common type of arrhythmia and an important risk factor for an increase in cerebrovascular illness. The action potential (AP) of a cardiomyocyte is initiated by the depolarization of the membrane through the inflow of sodium (Na+). The repolarization currents are realized by different potassium (K+) channels. Background currents of TASK-1 channels can also contribute to AP, and TASK-1 channel blockers could become innovative strategies against AF. The compounds used in this study were based on local anesthetic (LAs)-type compounds that have been shown to be TASK-1 channel blockers, such as lidocaine, ropivacaine, and bupivacaine, and that have antiarrhythmic capacity, becoming potentially effective drugs for the treatment of AF. The main objective of this study was, based on the common characteristics of LAs, to propose the synthesis of analogues of LAs and evaluate them in silico as TASK-1 channel blockers.
Parallel Adaptive Evolutionary Algorithms for Pressurized Water Reactor Reload Pattern Optimizations

The combination of traditional evolution strategies and heuristics from expert knowledge leads to the RELOPAT optimization program. In combination with reactor simulation codes - in this investigation the nodal reactor code PRISM of Siemens/KWU-a powerful program system for the design of a numerically optimized pressurized water reactor (PWR) loading pattern was designed. Furthermore, the technic of parallel computing was introduced successfully. Simple parallel algorithmic structures on the level of optimization algorithms, combined with a low amount of communication between processors, allow workstation clusters to be used efficiently. Highly promising results were obtained by comparing recalculations of different known loading patterns for several PWRs of different sizes and varying constraints with solutions based on human expertise. The economic potential of the improvements now leads to a program that meets industrial requirements.