Miracle-dz/UniFAR-FTUs huggingface dataset:
Quantity and quality of randomized controlled trials published by Indian physiotherapists

Background and Objectives: Randomized controlled trials (RCTs) are considered as the gold standard evidence for determining efficacy of interventions. Physiotherapeutic interventions are essential in the management of various conditions. However, information on the quantity and quality of RCTs published by Indian physiotherapists is largely unknown. Therefore, the primary objective of this study was to review the RCTs published by Indian physiotherapists for analyzing publication trend and its quality. Materials and Methods: Medline database was searched for eligible RCTs published by Indian physiotherapists between the years 2000 and 2013. We performed quantitative analysis of RCTs including type of participants, area of focus in physiotherapy, clinical condition and geographical location of first author's affiliation and analyzed the methodological quality and reporting of RCTs using Physiotherapy Evidence Database (PEDro) scale and consolidated standards of reporting trials (CONSORTs) key criterion statement, respectively. Results: A total of 45 RCTs have been published by Indian physiotherapists. The common conditions investigated in the trials were low back pain (16.3%), followed by diabetes (6.7%) and chronic obstructive pulmonary disease (6.7%). The mean score of PEDro is 5.5 (standard deviation: 1.2). Trial registration (3 [7%]) and sample size calculation (28.9%) are the most common CONSORT items not reported in the trials. Interpretation and Conclusions: RCTs published by Indian physiotherapists is gradually increasing in numbers and the methodological qualities of studies are fair. However, there is substantial scope for improvement in conducting and reporting trials. In the future, Indian physiotherapists should focus more on conditions such as stroke, asthma, and others, which have a larger burden of illness among Indian population.
Imaging the adult zebrafish cone mosaic using optical coherence tomography

Abstract Zebrafish (Danio rerio) provide many advantages as a model organism for studying ocular disease and development, and there is great interest in the ability to non-invasively assess their photoreceptor mosaic. Despite recent applications of scanning light ophthalmoscopy, fundus photography, and gonioscopy to in vivo imaging of the adult zebrafish eye, current techniques either lack accurate scaling information (limiting quantitative analyses) or require euthanizing the fish (precluding longitudinal analyses). Here we describe improved methods for imaging the adult zebrafish retina using spectral domain optical coherence tomography (OCT). Transgenic fli1:eGFP zebrafish were imaged using the Bioptigen Envisu R2200 broadband source OCT with a 12-mm telecentric probe to measure axial length and a mouse retina probe to acquire retinal volume scans subtending 1.2 × 1.2 mm nominally. En face summed volume projections were generated from the volume scans using custom software that allows the user to create contours tailored to specific retinal layer(s) of interest. Following imaging, the eyes were dissected for ex vivo fluorescence microscopy, and measurements of blood vessel branch points were compared to those made from the en face OCT images to determine the OCT lateral scale as a function of axial length. Using this scaling model, we imaged the photoreceptor layer of five wild-type zebrafish and quantified the density and packing geometry of the UV cone submosaic. Our in vivo cone density measurements agreed with measurements from previously published histology values. The method presented here allows accurate, quantitative assessment of cone structure in vivo and will be useful for longitudinal studies of the zebrafish cone mosaics.
Toward Human-Like Real-Time Manipulation: From Perception to Motion Planning

Human-like behavior is crucial for intelligent service robots that are to perform versatile tasks in day to day life. In this paper, an integrated approach to human-like manipulation is presented, which addresses realtime three-dimensional (3-D) workspace modeling and accessibility analysis for motion planning. The 3-D workspace modeling uses three main principles: identification of global geometric features, substitution of recognized known objects by corresponding solid models in the database and multi-resolution representation of unknown obstacles as required by the task at hand. Accessibility analysis is done through visibility tests. It complements and accelerates general motion planning. The experimental results demonstrate that the human-like behavior-oriented methods are sufficiently fast and robust to model 3-D workspace, and to plan and execute tasks for robotic manipulative applications.
Amendment history : Corrigendum ( April 2005 ) Liver fibrosis Ramón Bataller

Liver fibrosis is the excessive accumulation of extracellular matrix proteins including collagen that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in cirrhosis, liver failure, and portal hypertension and often requires liver transplantation. Our knowledge of the cellular and molecular mechanisms of liver fibrosis has greatly advanced. Activated hepatic stellate cells, portal fibroblasts, and myofibroblasts of bone marrow origin have been identified as major collagen-producing cells in the injured liver. These cells are activated by fibrogenic cytokines such as TGF-b1, angiotensin II, and leptin. Reversibility of advanced liver fibrosis in patients has been recently documented, which has stimulated researchers to develop antifibrotic drugs. Emerging antifibrotic therapies are aimed at inhibiting the accumulation of fibrogenic cells and/or preventing the deposition of extracellular matrix proteins. Although many therapeutic interventions are effective in experimental models of liver fibrosis, their efficacy and safety in humans is unknown. This review summarizes recent progress in the study of the pathogenesis and diagnosis of liver fibrosis and discusses current antifibrotic strategies. Science in Medicine
A bipolar MMIC frequency tripler

A concept for an MMIC frequency tripler using SiGe HBT's is proposed and verified in this paper. The main circuit of this tripler consists of a differential-pair frequency doubler followed by a single-balanced mixer that multiplies the doubler output with the fundamental frequency input to generate the triple-frequency output. The single-balanced mixer is an emitter-coupled differential pair and because its output is taken differentially by a differential output stage, the even harmonics are highly suppressed. An on-chip LC notch filter is further introduced in the output stage to suppress the fundamental, leaving the triple frequency dominating the output. The designed tripler can convert a 3-GHz input signal to a 9-GHz signal, with high suppressions of 28 dB, 22 dB, and 30 dB on the fundamental, the second, and 4th harmonics respectively.
Spousal employment and intra-household bargaining power

This article considers the relationship between work status and decision-making power of the head of household and his spouse. I used household fixed effects models to address the possibility that spousal work status may be correlated with unobserved factors that also affect bargaining power within the home. Consistent with the hypothesis that greater economic resources yield greater bargaining power, I found that the spouse of the head of household is more likely to be involved in making decisions when she has been employed. Similarly, the head of household is less likely to be the sole decision-maker when his spouse works.
Divergence of Eukaryotic Secretory Components: the Candida albicans Homolog of the Saccharomyces cerevisiae Sec20 Protein Is N Terminally Truncated, and Its Levels Determine Antifungal Drug Resistance and Growth

ABSTRACT Sec20p is a component of the yeast Saccharomyces cerevisiae secretory pathway that does not have a close homolog in higher eukaryotic cells. To verify the function of Sec20p in other fungal species, we characterized the gene encoding a Sec20p homolog in the human fungal pathogen Candida albicans. The deduced protein has 27% identity with, but is missing about 100 N-terminal residues compared to S. cerevisiae Sec20p, which is part of the cytoplasmic tail interacting with the cytoplasmic protein Tip20p. Because a strain lacking both C. albicans SEC20alleles could not be constructed, we placed SEC20 under transcriptional control of two regulatable promoters, MET3pand PCK1p. Repression of SEC20 expression in these strains prevented (MET3p-SEC20 allele) or retarded (PCK1p-SEC20 allele) growth and led to the appearance of extensive intracellular membranes, which frequently formed stacks. Reduced SEC20 expression in the PCK1p-SEC20strain did not affect morphogenesis but led to a series of hypersensitivity phenotypes including supersensitivity to aminoglycoside antibiotics, to nystatin, to sodium dodecyl sulfate, and to cell wall inhibitors. These results demonstrate the occurrence and function of Sec20p in a fungal species other than S. cerevisiae, but the lack of the N-terminal domain and the apparent absence of a close TIP20 homolog in the C. albicans genome also indicate a considerable diversity in mechanisms of retrograde vesicle traffic in eukaryotes.
Design of visual odometry system for mobile robot

This paper deals with design of hybrid software and hardware sensor, which can be used for mobile robots visual odometry task. The paper is focused to sensing raw data only. This approach combines onboard hardware sensors - accelerometer, gyroscope, magnetometer and camera with software module, which is mainly based on computer vision. Output from vision system is relative change of position and rotation of mobile robot. The position change is calculated for two axes based on vision data and the relative rotation is based on data fusion of three onboard sensors.
A Theoretical Investigation on CMOL FPGA Cell Assignment Problem

The hybrid CMOS/nano circuits (CMOL) field-programmable gate array (FPGA) is a promising nanotechnology that has the potential to be accepted by industry in the future. However, a primary question to be addressed is whether or not all circuits can be mapped on CMOL architecture. In contrast to traditional placement and routing problems, CMOL cell assignment has the constraint that each gate can only be wired to a limited number of gates in its neighborhood. Under such a restriction, not all circuits are directly placeable. This paper presents two theoretical results concerning whether a combinatorial circuit is placeable in CMOL FPGA. For any finite connection domain, we prove the existence of a few nonplaceable circuits under certain conditions. Given a reasonable connection domain size, we show that any combinatorial circuit can be transformed to an equivalent circuit which is placeable. These results conclude that the CMOL cell assignment problem is solvable but circuit modification has to be part of the placement procedure.
Forty lives in the bebop business: Mental health in a group of eminent jazz musicians

Background Above-average levels of psychopathology have been demonstrated convincingly in groups of outstanding individuals working in the arts. Currently, jazz musicians have not been studied in this regard. Aims To investigate any evidence of psychopathology in a group of eminent jazz musicians. Method Biographical material relating to 40 eminent American modern jazz musicians was reviewed and an attempt was made to formulate diagnoses using DSM–IV. Results Evidence was provided of levels of psychopathology in the sample of jazz musicians similar to those found in other previously investigated creative groups, with the exception of substance-related problems. An interesting connection between creativity and sensation-seeking was highlighted. Conclusions The link between psychopathology and creativity in the arts was given further weight. Future studies of jazz musicians using larger samples and making comparison with groups from different eras of music would give greater clarification to this area.
Pulling Together and Pushing Apart: Tides of Tension in the ICU Team

Balancing interdisciplinary differences and coping with the strain of limited resources, intensive care unit (ICU) teams face the physical and psychological stress of caring for the critically ill. Differences in knowledge and skill, gender, and care models are organized by a complex hierarchical structure that does not always adequately account for these differences. Thus, ICU teams not only face the challenge of working efficiently in a highly stressful acute care environment, they also confront the complexities of interprofessional communication and collaboration. Multifaceted interprofessional relationships must be established and re-established as individual providers continuously rotate to and from the unit. These characteristics provide the context for potentially divisive team communication and pose significant challenges to team collaboration. Problems in team communication and collaboration may have significant impact on administrative, social, clinical, and educational outcomes in the ICU. Previous studies have highlighted the importance of collaboration in improving patient outcomes, in decision making around ethical issues and in improving the team’s morale. Other studies have focused on physician–nurse interactions and describe inadequate communication of treatment goals and a lack of collaboration, as well as a lack of understanding and frank disputes over roles and responsibilities. This study examines communication patterns in the context of this continuously shifting interprofessional team. Further, it explores the implications of these patterns for the education and socialization of critical care trainees as they negotiate professional roles and relationships within the hidden curriculum of critical care medicine.
Heterogeneity of Patients with Intermediate (BCLC B) Hepatocellular Carcinoma: Proposal for a Subclassification to Facilitate Treatment Decisions

Abstract The intermediate stage of hepatocellular carcinoma (HCC) comprises a highly heterogeneous patient population and therefore poses unique challenges for therapeutic management, different from the early and advanced stages. Patients classified as having intermediate HCC by the Barcelona Clinic Liver Cancer (BCLC) staging system present with varying tumor burden and liver function. Transarterial chemoembolization (TACE) is currently recommended as the standard of care in this setting, but there is considerable variation in the clinical benefit patients derive from this treatment. In April 2012, a panel of experts convened to discuss unresolved issues surrounding the application of current guidelines when managing patients with intermediate HCC. The meeting explored the applicability of a subclassification system for intermediate HCC patients to tailor therapeutic interventions based on the evidence available to date and expert opinion. The present report summarizes the proposal of the expert panel: four substages of intermediate HCC patients, B1 to B4.
Dietary phytoestrogen intake and cognitive function in older women.

BACKGROUND Aging is associated with a decline in cognitive function; we explored the possible influence of dietary phytoestrogens on this decline. METHODS We conducted a cross-sectional study in 301 Dutch women aged 60-75 years. Dietary isoflavone and lignan intake was assessed with a food-frequency questionnaire covering habitual diet in the year preceding enrolment. The endpoints were cognitive function measured in three domains: memory, processing capacity and speed, and executive function. Data were analyzed using linear regression models, after adjusting for confounders. RESULTS No association between dietary isoflavone intake and cognitive function was found. High lignan intake was associated with a better performance in processing capacity and speed, and in executive function (p for trend over quartiles =.01 and.02, respectively). CONCLUSIONS This finding calls for further research to elucidate the relatively underexplored role of lignans within the range of phytoestrogens.
Association Between Adolescent Marriage and Intimate Partner Violence

This study explores the association between adolescent marriage and intimate partner violence (IPV) among young adult women using 2007 Bangladesh Demographic Health Survey data. The analyses are restricted to young women 20 to 24 years old. Logistic regression analyses are constructed to estimate the odds ratios and 95% confidence intervals for the association between adolescent marriage and IPV in the past year. Results show that there is a strong significant relationship between adolescent marriage and experience of physical IPV in the past year among this population. Association between sexual IPV and adolescent marriage is insignificant. Adolescent marriage puts women at increased risk of physical IPV into their young adult period. Government agencies need to enforce existing law on the minimum age at marriage to reduce IPV among adolescent and young adult girls.
Fatty acid profiles of milk and Minas frescal cheese from lactating grazed cows supplemented with peanut cake

Milk and Minas frescal cheese were evaluated from crossbred Holstein × Gir cows that were fed diets enriched with 0, 33, 66 and 100% inclusion levels of palm kernel cake in a concentrated supplement in replace of soybean meal. Eight crossbred lactating cows were distributed (four animals × four treatments × four periods) in the experimental design of double 4 × 4 Latin squares. The capric (C : 10, P = 0·0270), undecylic (C : 11, P = 0·0134), and lauric (C : 12, P = 0·0342) saturated fatty acid concentrations and CLA (C18 : 2c9t11, P = 0·0164) of the milk fat decreased linearly with an increasing percentage of peanut cake in the diet. The increased peanut cake content (100%) in the diet was associated with a linear decrease in C : 10 (P = 0·0447), C : 12 (P = 0·0002), mirystic (C : 14, P < 0·0001) and palmitic (C : 16, P < 0·0001) saturated fatty acid concentrations and an increase in arachidic, lignoceric, palmitoleic and elaidic acid levels in the Minas frescal cheese fat made from the milk. Both the milk and the Minas frescal cheese showed a linear decrease in the concentration of monosaturated fatty acids (P < 0·0001), atherogenicity index, and thrombogenicity index (P < 0·05), while the hypocholesterolaemic: hypercholesterolaemic and omega 6: omega 3 (P > 0·05) ratios were not influenced by the different peanut cake levels. The inclusion of up to 100% peanut cake as a substitution for soybean meal in the concentrate of grazing lactating cows resulted in changes in the nutritional quality of their milk products, as indicated by the increase in polyunsaturated fatty acids and the decrease of saturated fatty acids (lauric, myristic, and palmitic).
articleSingle minimum incision endoscopic radical nephrectomy for renal tumors with preoperative virtual navigation using 3 DCT volume-rendering

Background: Single minimum incision endoscopic surgery (MIES) involves the use of a flexible high-definition laparoscope to facilitate open surgery. We reviewed our method of radical nephrectomy for renal tumors, which is single MIES combined with preoperative virtual surgery employing three-dimensional CT images reconstructed by the volume rendering method (3D-CT images) in order to safely and appropriately approach the renal hilar vessels. We also assessed the usefulness of 3D-CT images. Methods: Radical nephrectomy was done by single MIES via the translumbar approach in 80 consecutive patients. We performed the initial 20 MIES nephrectomies without preoperative 3D-CT images and the subsequent 60 MIES nephrectomies with preoperative 3D-CT images for evaluation of the renal hilar vessels and the relation of each tumor to the surrounding structures. On the basis of the 3D information, preoperative virtual surgery was performed with a
Survey of Hospital Drains Antibiotic Resistant Bacteria for Hygiene and Health Care

The antimicrobial susceptibility of twelve bacterial isolates obtained from different three hospital drains in Cairo, Egypt isolated within three months was determined, using agar diffusion method. Only twelve out of twenty-eight antibiotic resistant bacterial isolates were selected according to their sensitivity for equal or more than two antibiotics used. Isolates from hospital drains were subjected to antimicrobial susceptibility testing and the percent of resistance bacteria were subjected to thirteen antibiotics as the following: CN (58.3%), CAZ (91.7%), CTX (91.7%), TOB (83.3%), CEP (83.3%), IPM (25.0%), SXT (33.3%), VA (75.0%), AK (25.0%), SAM (58.3%), FEP (50.0%), CIP (8.3%), and CRO (75.0%). The relationship between plasmid and antibiotic resistant bacteria explained from pharmaceutical products isolates and detected two plasmids while isolates from hospital drains detected also two plasmids and one isolate detected four plasmids.
Mycobacterium ulcerans toxin, mycolactone may enhance host‐seeking and oviposition behaviour by Aedes aegypti (L.) (Diptera: Culicidae)

The ecological functions of many toxins continue to remain unknown for those produced by environmental pathogens. Mycobacterium ulcerans, the causative agent of the neglected tropical disease, Buruli ulcer, produces a cytotoxic macrolide, mycolactone, whose function(s) in the environment remains elusive. Through a series of dual-choice behaviour assays, they show that mycolactone may be an interkingdom cue for the yellow fever mosquito, Aedes aegypti, seeking blood-meals as well as oviposition sites. Results provide novel insight into the evolution between bacteria and potential vectors. While further studies are needed to determine if mycolactone is an actual signal rather than simply a cue, this discovery could serve as a model for determining roles for toxins produced by other environmental pathogens and provide opportunities for developing novel strategies for disease prevention. The relationship between M. ulcerans, mycolactone, and Ae. aegypti further suggests there could be an amplification effect for the spread of pathogens responsible for other diseases, such as yellow fever and dengue.
Far-field radiation pattern of red emitting thin-film resonant cavity LEDs

AlGaInP thin-film resonant cavity light-emitting diodes (RCLEDs) show an improved performance compared to standard red emitting RCLEDs. External quantum efficiencies at 650 nm of 23% and 18% with and without encapsulation, respectively, have been obtained for devices showing a maximum emission in the normal direction. Thanks to the high angle-averaged reflectivity of the bottom hybrid mirror, a strong photon recycling effect occurs in these structures. The decrease of the absorption with increasing injection level reduces photon recycling and increases extraction of lateral guided modes. The redirection of part of the emission from the vertical to the lateral direction with increasing current density is reflected in the evolution of the far-field radiation pattern.