Miracle-dz/UniFAR-FTUs huggingface dataset:
Between friends: Forgiveness, unforgiveness, and wrongdoing in same-sex friendships

Friendships fulfill needs for intimacy, belonging, and support and yet have rarely been the focus of forgiveness research. In this study, we explored forgiveness, unforgiveness, and young adults’ experiences of transgressions in same-sex friendships (N = 407). Our results suggest that, although forgiveness and unforgiveness share important antecedents (e.g., apology status, perceived remorse, and barriers to forgiveness), they are nevertheless empirically distinct constructs, both worthy of further investigation in friendships. For example, unforgiveness predicted unique variance in current friendship status controlling for forgiveness. We discuss several lessons learned from our study about the nature of responses to wrongdoing among same-sex friends (e.g., even when forgiven, offenses may cause longstanding changes in people’s views of their offending friends).
Secondary Structure and X-Ray Crystallographic Analysis of the Glideosome-Associated Connector (GAC) from Toxoplasma gondii

A model for parasitic motility has been proposed in which parasite filamentous actin (F-actin) is attached to surface adhesins by a large component of the glideosome, known as the glideosome-associated connector protein (GAC). This large 286 kDa protein interacts at the cytoplasmic face of the plasma membrane with the phosphatidic acid-enriched inner leaflet and cytosolic tails of surface adhesins to connect them to the parasite actomyosin system. GAC is observed initially to the conoid at the apical pole and re-localised with the glideosome to the basal pole in gliding parasite. GAC presumably functions in force transmission to surface adhesins in the plasma membrane and not in force generation. Proper connection between F-actin and the adhesins is as important for motility and invasion as motor operation itself. This notion highlights the need for new structural information on GAC interactions, which has eluded the field since its discovery. We have obtained crystals that diffracted to 2.6-2.9 Å for full-length GAC from Toxoplasma gondii in native and selenomethionine-labelled forms. These crystals belong to space group P212121, cell dimensions are roughly a=119 Å, b=123Å, c=221Å, α=90, β=90, γ=90 with 1 molecule per asymmetric unit, suggesting a more compact conformation than previously proposed.
Post-collisional and volcanic features of the Late Miocene-Pleistocene foreland area, northern offshore Taiwan

Based on multichannel seismic data northern offshore Taiwan, we revisited the post-collisional and volcanic features in the Late Miocene-Pleistocene wedge-top of the early Taiwan orogenic wedge. Seismic data transverse to wedge-top zone show the asymmetric and symmetric folds, along with blind thrusts and back thrusts. Seis-mic data parallel to the axis of the wedge-top zone show the volcanic features of poor stratified reflectors, forced fold and intrusive step of volcanic sills along and away from dominating normal fault structures. Since the volcanic extrusions and normal faults are probably associated events, we suggest that post-collisional extensional volcanism northern offshore Taiwan was probably formed along inherited primary and secondary fault structures. The wedge-top zone was formed at frontal part of the early Taiwan orogenic wedge in Late Miocene. Subsequent change of regional stress from convergence to extension led to the mountain collapse as well as primary and secondary normal faults. Thus, these post-collisional normal faults are mechanically weak, probably capable of providing pathways for the Pleistocene-present vol-canisms northern offshore Taiwan. The facilitation of post-collisional fault structures as transportation routes for deep material to migrate along may be important for the formation of the Quaternary volcanism extrusions northern offshore Taiwan.
PEMBERDAYAAN MASYARAKAT MELALUI PROGRAM KELOMPOK SENI DAN USAHA KECIL MENENGAH KELURAHAN MANGKUBUMEN (MPOK SINAH KLAMBEN) (Studi Di Kelurahan Mangkubumen, Kecamatan Banjarsari, Kota Surakarta)

Community empowerment is one of the development steps that can be interpreted as a process of empowering the community through its expertise and potential, with the hope that the community can develop themselves more independently. Mangkubumen Village is one of the villages that seeks to empower the community, one of which is through the Mangkubumen Village Small and Medium Enterprises and Arts Group Program (Mpok Sinah Klamben). This study aims to determine the process of community empowerment through the Mpok Sinah Klamben Program. The research method used is descriptive qualitative with data collection techniques through interviews, observation, and documentation. Informants in this research were selected purposively. The validity of the data used is a data triangulation technique or source, while the data analysis technique used is an interactive analysis model from Miles and Huberman. The results showed that Community Empowerment through the Mpok Sinah Klamben Program had been carried out through three stages of empowerment, namely awareness, capacity building, and empowerment. The awareness stage has been carried out through outreach to the entire community. Most of the community supports this program, but there are also some who do not support it. The capacity building stage has been carried out through the formation of the Mpok Sinah Klamben Board, providing technical guidance and training, as well as developing the rules of the game between them. The empowerment stage has been carried out through providing supporting facilities, increasing promotions through social media, and involving Mpok Sinah Klamben in events.
Modeling, simulation, and hardware-in-the-loop transmission test system software development

This paper describes the development of a generic test cell software designed to overcome many vehicle-component testing difficulties by introducing modern, real-time control and simulation capabilities directly to laboratory test environments. Successfully demonstrated in a transmission test cell system, this software eliminated the need for internal combustion engines (ICE) and test-track vehicles. It incorporated the control of an advanced AC induction motor that electrically simulated the ICE and a DC dynamometer that electrically replicated vehicle loads. Engine behaviors controlled by the software included not only the average crankshaft torque production but also engine inertia and firing pulses, particularly during shifts. Vehicle loads included rolling resistance, aerodynamic drag, grade, and more importantly, vehicle inertia corresponding to sport utility, light truck, or passenger cars. Driver aggressiveness algorithms that compensated for sensitivity to high grade, forward/reverse driving, and extremely high speeds were also incorporated to properly track a variety of severe driving profiles. Test results validating the operation of the system against actual vehicle data is also included. The paper summarizes the elements required to accomplish these tasks.
Design of High-Power Static Wireless Power Transfer via Magnetic Induction: An Overview

Recent years have witnessed the booming development of wireless power transfer (WPT) via magnetic induction, which has the advantages of convenience, safety, and feasibility to special occasions. WPT can be applied to electric vehicles and ships, where high-power WPT technology is required to shorten the charging time with the increasing battery capacity. This paper reviews the state-of-the-art development of high-power static WPT systems via magnetic induction. Selected prototypes and demos of high-power WPT systems are demonstrated with key transfer characteristics and solutions. Theoretical foundation of magnetically coupled WPT systems is analyzed and the maximum power capability of coils is derived. Compensation topologies suitable for high-power applications are discussed. Four basic planar coils, namely the bipolar coil, the square coil, the circular coil, and the rectangular coil, are simulated and compared. The state-of-the-art silicon carbide MOSFET development is introduced. The power electronics converters with power elevation techniques, including cascading, paralleling and inductive elevation, are investigated. Future development of high-power WPT systems is discussed.
Protein Subcellular Localization Based on Evolutionary Information and Segmented Distribution

The prediction of protein subcellular localization not only is important for the study of protein structure and function but also can facilitate the design and development of new drugs. In recent years, feature extraction methods based on protein evolution information have attracted much attention and made good progress. Based on the protein position-specific score matrix (PSSM) obtained by PSI-BLAST, PSSM-GSD method is proposed according to the data distribution characteristics. In order to reflect the protein sequence information as much as possible, AAO method, PSSM-AAO method, and PSSM-GSD method are fused together. Then, conditional entropy-based classifier chain algorithm and support vector machine are used to locate multilabel proteins. Finally, we test Gpos-mPLoc and Gneg-mPLoc datasets, considering the severe imbalance of data, and select SMOTE algorithm to expand a few sample; the experiment shows that the AAO + PSSM ∗ method in the paper achieved 83.1% and 86.8% overall accuracy, respectively. After experimental comparison of different methods, AAO + PSSM ∗ has good performance and can effectively predict protein subcellular location.
Statistical models and computational tools for predicting complex traits and diseases

Predicting individual traits and diseases from genetic variants is critical to fulfilling the promise of personalized medicine. The genetic variants from genome-wide association studies (GWAS), including variants well below GWAS significance, can be aggregated into highly significant predictions across a wide range of complex traits and diseases. The recent arrival of large-sample public biobanks enables highly accurate polygenic predictions based on genetic variants across the whole genome. Various statistical methodologies and diverse computational tools have been introduced and developed to compute the polygenic risk score (PRS) more accurately. However, many researchers utilize PRS tools without a thorough understanding of the underlying model and how to specify the parameters for the best performance. It is advantageous to study the statistical models implemented in computational tools for PRS estimation and the formulas of parameters to be specified. Here, we review a variety of recent statistical methodologies and computational tools for PRS computation.
Does the Introduction of Online Voting Create Diversity in Representation?

The Internet’s effect on political communication is omnipresent. However, very few jurisdictions around the globe allow their citizens to cast their ballot online. What are the electoral consequences of this reform? Research, so far, has mainly looked at security considerations and effects on turnout. In this research note, we broaden the scope of prior studies by examining the effect of online voting on diversity in representation. Using the voting results of municipalities in the Canadian province of Ontario both before and after the implementation of online voting, we test whether this reform has increased the representation of women and youth. We do not find that Internet voting has any significant impact on which candidates are elected, with both the gender and age of elected mayors being constant across online and traditional elections. We further find that the number of woman candidates does not increase with online voting.
Summarizing my DHS Internship Experience

In this paper, the author addresses four main topics: (1) A description of the topic of his internship at the U.S. Department of Homeland Security; (2) A description of his contributions to the project; (3) A discussion of research directions beneficial to the Department of Homeland Security (DHS); and (4) A discussion of the impact the internship experience had on his career aspirations. He feels the first three points can best be addressed using the contents of a paper his mentor, Dr. Tina Eliassi-Rad, and he have published based on their work this summer [Roberts and Eliassi-Rad, 2006]. Sections 2 - 5 are intended for this purpose and have been excerpted from that paper. He concludes this paper in Section 6 with a discussion of the fourth point.
Work and oxygen consumption of isolated right ventricular papillary muscle in experimental pulmonary hypertension

Right-sided myocardial mechanical efficiency (work output/metabolic energy input) in pulmonary hypertension can be severely reduced. We determined the contribution of intrinsic myocardial determinants of efficiency using papillary muscle preparations from monocrotaline-induced pulmonary hypertensive (MCT-PH) rats. The hypothesis was tested that efficiency is reduced by mitochondrial dysfunction in addition to increased activation heat reported previously. Right ventricular (RV) muscle preparations were subjected to 5 Hz sinusoidal length changes at 37°C. Work and suprabasal oxygen consumption (VO2) were measured before and after cross-bridge inhibition by blebbistatin. Cytosolic cytochrome c concentration, myocyte cross-sectional area, proton permeability of the inner mitochondrial membrane (PP IMM), and monoamine oxidase (MAO)-A and glucose 6-phosphate dehydrogenase (G-6-PDH) activities and phosphatidylglycerol (PG) and cardiolipin (CL) contents were determined. Mechanical efficiency ranged from 23 to 11% in control (n = 6) and from 22 to 1% in MCT-PH (n = 15) and correlated with work (r2 = 0.68, P < 0.0001) but not with VO2 (r2 = 0.004, P = 0.7919). VO2 for cross-bridge cycling was proportional to work (r2 = 0.56, P = 0.0005). Blebbistatin-resistant VO2 (r2 = 0.32, P = 0.0167) and IMM PP (r2 = 0.36, P = 0.0110) correlated inversely with efficiency. Together, these variables explained the variance of efficiency (coefficient of multiple determination R2 = 0.79, P = 0.0001). Cytosolic cytochrome c correlated inversely with work (r2 = 0.28, P = 0.0391), but not with efficiency (r2 = 0.20, P = 0.0867). G-6-PDH, MAO-A and PG/CL increased in the RV wall of MCT-PH but did not correlate with efficiency. Reduced myocardial efficiency in MCT-PH is due to activation processes and mitochondrial dysfunction. The variance of work and the ratio of activation heat reported previously and blebbistatin-resistant VO2 are discussed. Key points Mechanical efficiency of right ventricular myocardium is reduced in pulmonary hypertension. Increased energy use for activation processes has been demonstrated previously, but the contribution of mitochondrial dysfunction is unknown. Work and oxygen consumption is determined during work loops. Oxygen consumption for activation and cross-bridge cycling confirm the previous heat measurements. Cytosolic cytochrome c concentration, proton permeability of the mitochondrial inner membrane and phosphatidylglycerol/cardiolipin are increased in experimental pulmonary hypertension. Mitochondrial dysfunction in right ventricular myocytes is related to reduced work and mechanical efficiency in experimental pulmonary hypertension. Upregulation of the pentose phosphate pathway and a potential gap in the energy balance suggest mitochondrial dysfunction in right ventricular overload is due to excessive production of reactive oxygen species.
A Dual-Band High-Gain Subwavelength Cavity Antenna with Artificial Magnetic Conductor Metamaterial Microstructures

This paper presents dual-band high-gain subwavelength cavity antennas with artificial magnetic conductor (AMC) metamaterial microstructures. We developed an AMC metamaterial plate that can be equivalent to mu-negative metamaterials (MNMs) at two frequencies using periodic microstructure unit cells. A cavity antenna was constructed using the dual-band AMC metamaterial plate as the covering layer and utilizing a feed patch antenna with slot loading as the radiation source. The antenna was fabricated with a printed circuit board (PCB) process and measured in an anechoic chamber. The |S11| of the antenna was −26.8 dB and −23.2 dB at 3.75 GHz and 5.66 GHz, respectively, and the realized gain was 15.2 dBi and 18.8 dBi at two resonant frequencies. The thickness of the cavity, a sub-wavelength thickness cavity, was 15 mm, less than one fifth of the long resonant wavelength and less than one third of the short resonant wavelength. This new antenna has the advantages of low profile, light weight, dual-frequency capability, high gain, and easy processing.
A Bayesian framework for parameters estimation in complex system

The real-life complex development situations express that the methods applied to new product development process content reliability risks which require assessment and quantification at the earliest stage, extracting relevant information from the process. Reliability targets have to be realistic and systematically defined, in a meaningful way for marketing, engineering, testing, and production. Potential problems proactively identified and solved during design phase and products launched at or near planned reliability targets eliminate extensive and prolonged improvement efforts after start on. Once in the market, products standard procedures require monitoring of early signs of issues, allowing corrective action to be quickly taken. Reliability validation before a product goes to market by the means of Bayesian statistical method because the model has shorter confidence intervals than the classical statistical inference models, allowing a more accurate decision-making process. The paper proposes the estimation of the shape parameters in a complex data structures approached with exponential gamma distribution as model of life time, reliability and failure rate functions. The numerical simulation performed in the case study validates the correctness of the proposed methodology.
Multi-objective optimization of Ironless PMLSM based on Semi-Analytical Model Using Genetic-Particle Swarm Optimization Algorithm

Using 3D FEM to achieve optimal design for long stator Ironless permanent magnet linear synchronous motor (PMLSM) with many design parameters is computationally an expensive task. To reduce design time without loss of accuracy, the end winding inductance model is established in this paper. Then the end winding inductance model and 2D FEM(Semi-Analytical) were combined to replace the 3D FEM model. Finally, the optimal design set of PMLSM can be obtained quickly and accurately based on Semi-Analytical by Genetic-Particle Swarm Optimization Algorithm (GAPOS).
The DEXA-CORT trial: study protocol of a randomised placebo-controlled trial of hydrocortisone in patients with brain tumour on the prevention of neuropsychiatric adverse effects caused by perioperative dexamethasone

Introduction The synthetic glucocorticoid dexamethasone can induce serious neuropsychiatric adverse effects. Dexamethasone activates the glucocorticoid receptor (GR) but, unlike endogenous cortisol, not the mineralocorticoid receptor (MR). Moreover, dexamethasone suppresses cortisol production, thereby eliminating its MR binding. Consequently, GR overactivation combined with MR underactivation may contribute to the neuropsychiatric adverse effects of dexamethasone. The DEXA-CORT trial aims to reactivate the MR using cortisol to reduce neuropsychiatric adverse effects of dexamethasone treatment. Methods and analysis The DEXA-CORT study is a multicentre, randomised, double-blind, placebo-controlled trial in adult patients who undergo elective brain tumour resection treated perioperatively with high doses of dexamethasone to minimise cerebral oedema. 180 patients are randomised between treatment with either two times per day 10 mg hydrocortisone or placebo during dexamethasone treatment. The primary study outcome is the difference in proportion of patients scoring ≥3 points on at least one of the Brief Psychiatric Rating Scale (BPRS) questions 5 days postoperatively or earlier at discharge. Secondary outcomes are neuropsychiatric symptoms, quality of sleep, health-related quality of life and neurocognitive functioning at several time points postoperatively. Furthermore, neuropsychiatric history, serious adverse events, prescribed (psychiatric) medication and referrals or evaluations of psychiatrist/psychologist and laboratory measurements are assessed. Ethics and dissemination The study protocol has been approved by the Medical Research Ethics Committee of the Leiden University Medical Center, and by the Dutch competent authority, and by the Institutional Review Boards of the participating sites. It is an investigator-initiated study with financial support by The Netherlands Organisation for Health Research and Development (ZonMw) and the Dutch Brain Foundation. Results of the study will be submitted for publication in a peer-reviewed journal. Trial registration number NL6726 (Netherlands Trial Register); open for patient inclusion. EudraCT number 2017-003705-17.
Sequential Sterilization of Banana (Musa Spp.) Sucker Tip Reducing Microbial Contamination With Highest Establishment Percentage

Sterilization procedure was standardized for grand naine cultivar of banana using various sterilants in combinations and alone. The observations were recorded regularly with respect to presence of fungal, bacteria as well as percentages of culture establishment. Results indicated that a treatment combination No. 3 [Lactic acid (0.15 %) + Tween-20 (0.1 %) + 0.8 % Commercial bleach (30 Min.) followed by Sodium chlorite (0.3 %) (20 min)] gave the highest percentage of aseptic culture establishment in vitro condition. The present study also showed that, single step aseptic inoculation was unable to control endophytic contaminants while sequential treatments were good enough to reduce microbial load as well as increase culture survival. Bangladesh J. Bot. 50(4): 1151-1158, 2021 (December)
Identifying Neural Markers of Peer Dysfunction in Girls with ADHD

Very little research has prioritized girls with ADHD, despite accumulating evidence showing that girls with ADHD experience broader and more severe peer dysfunction relative to boys with ADHD. Attention to identifying the neural mechanisms underlying the peer difficulties of girls with ADHD is critical in order to develop targeted intervention strategies to improve peer functioning. New efforts to address the peer dysfunction of girls with ADHD are discussed.
Dietary Acid Load, Serum Polychlorinated Biphenyl Levels, and Mortality Following Breast Cancer in the Long Island Breast Cancer Study Project

Dietary acid load (DAL) may be associated with all-cause mortality (ACM) and breast cancer-specific mortality (BCM), and these associations may be modified by serum polychlorinated biphenyl (PCB) levels. Participants included 519 women diagnosed with first primary in situ or invasive breast cancer in 1996/1997 with available lipid-corrected PCB data. After a median of 17 years, there were 217 deaths (73 BCM). Potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores calculated from a baseline food frequency questionnaire estimated DAL. Cox regression estimated covariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between PRAL and NEAP with mortality. We evaluated effect measure modification by total serum PCB levels (>median vs. ≤median). PRAL quartile 4 versus quartile 1 was associated with an ACM HR of 1.31 (95%CI = 0.90–1.92). In the upper median of PCBs, ACM HRs were 1.43 (95%CI = 0.96–2.11) and 1.40 (95%CI = 0.94–2.07) for PRAL and NEAP upper medians, respectively. In the lower median of PCBs, the upper median of NEAP was inversely associated with BCM (HR = 0.40, 95%CI = 0.19–0.85). DAL may be associated with increased risk of all-cause mortality following breast cancer among women with high total serum PCB levels, but inversely associated with breast cancer mortality among women with low PCB levels.