Miracle-dz/UniFAR-FTUs huggingface dataset:
Design and Development of a Compact Real Time ECG Device

Arrhythmia is the irregularity in normal heart rhythm which may lead to cardiovascular diseases like heart attack, blood pressure and stroke. Cardiac arrhythmia occurs in up to 86% of patients during anesthesia and surgery. So it is considerably important to detect these arrhythmia. In present work, Ventricular Tachycardia (VT), Atrial Fibrillation (AF), Left Bundle Branch Block (LBBB) and Right Bundle Branch Block (RBBB) have been displayed on CRO from the ECG device. The device is made compact by the use of surface mount device (SMD) technology. The developed device consists of hardware design with AD8232 for ECG extraction, with a gain of 100. Microcontroller to convert analog signal from AD8232 to digital form. Microcontroller is programmed using embedded C language in Atmel studio-7.0 version for ADC (Analog to Digital conversion) conversion, GPIO (General Purpose Input Output) and wireless Bluetooth transmission through UART communication. Bluetooth is used to transfer ECG data into the PC. The arrhythmia conditions were given from the ECG simulator to the developed device. The output was tapped from the developed ECG board and displayed on the CRO. The device has been tested for more than 20 arrhythmia conditions and it was able to display all the conditions on the CRO.
The Impact of Corporate Governance and Leadership on Organizational Success

There are several themes, especially a fixated reliance on the Board’s structure/composition to evaluate effectiveness of corporate governance, controversial for a small/medium sized firm as the former approach is primarily designed with large corporations in mind. It was basically a qualitative research underpinned by a case study of organization XXX was conducted in order to explore the impact of corporate governance and leadership on organizational success. Data was collected via semi-structured interviews, transcribed and analysed using the grounded theory (Straussian method), revealing XXX’s pursuit of organizational success as an on-going crusade, with impediments to be addressed. A contextual look into corporate governance model for a small firm was undertaken. Corporate governance’s strengths contributing to and limitations impeding organizational success were examined. Also, leadership strengths and limitations were also examined. The study revealed that, leadership effectiveness can be measured by the degree of relationships formed rather than styles/types, which vary by leaders’ personalities. Leader-member exchange (LMX) provides the platform for relationships to be formed and strengthened by culture of values.
Customer Service Satisfaction among Hotels and Restaurants in Tandag City, Surigao Del Sur, Philippines

Customer satisfaction is the key driver for any organization to sustain in current competitive era. Service providers need to understand their customers and design their services in such a way that maximum possible satisfaction is attained by the customer. This paper assesses the quality of customer service satisfaction among hotels and restaurants in Tandag City, with an end view of formulating a customer service training design to improve the level of customer service satisfaction. Guided by the SERVQUAL study to ascertain the findings, the paper utilizes descriptive survey research design. A total of 200 survey questionnaires are distributed to 35 hotel and restaurant employees and 155 customers. Primary data are collected using the drop-off and pick-up method of self-administered questionnaire through convenience and purposive sampling technique. The types of analyses conducted were descriptive, frequency, weighted mean and Pearson correlation. Results reveal that both the employees and customers are very satisfied with the service quality afforded by the hotels and restaurants in Tandag City. Findings from the correlational analysis reveal that both employees and customers deemed the components of assurance, reliability, tangibility, empathy and responsiveness as important aspects in the delivery of services.
Analysis and shortcomings of e-recruitment systems: Towards a semantics-based approach addressing knowledge incompleteness and limited domain coverage

The rapid development of the Internet has led to introducing new methods for e-recruitment and human resources management. These methods aim to systematically address the limitations of conventional recruitment procedures through incorporating natural language processing tools and semantics-based methods. In this context, for a given job post, applicant resumes (usually uploaded as free-text unstructured documents in different formats such as .pdf, .doc or .rtf) are matched/screened out using the conventional keyword-based model enriched by additional resources such as occupational categories and semantics-based techniques. Employing these techniques has proved to be effective in reducing the cost, time, and efforts required in traditional recruitment and candidate selection methods. However, bridging the skill gap - that is, the propensity to precisely detect and extract relevant skills in applicant resumes and job posts - and highlighting the hidden semantic dimensions encoded in applicant resumes are still challenging issues in the process of devising effective e-recruitment systems. This is due to the fact that resources exploited by current e-recruitment systems are obtained from generic domain-independent sources, therefore resulting in knowledge incompleteness and the lack of domain coverage. In this article, we review state-of-the-art e-recruitment approaches and highlight recent advancements in this domain. An e-recruitment framework addressing current shortcomings through the use of multiple cooperative semantic resources, feature extraction techniques and skill relatedness measures is detailed. An instantiation of the proposed framework is proposed and an experimental validation using a real-world recruitment dataset from two employment portals demonstrates the effectiveness of the proposed approach.
Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy

Abstract In this study, we report a complete (clinical, radiological, and virological) sustained (1 year) response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of the cells infiltrate in a pretreatment brain biopsy suggest that parenchymal programmed cell death-L1+ macrophages could be the T-cells partnership in immune exhaustion and virus escape.
Acute and Chronic Responses of Aerobic Exercise With Blood Flow Restriction: A Systematic Review

This study systematically reviewed the available scientific evidence pertaining to the acute and chronic changes promoted by aerobic exercise (AE) combined with blood flow restriction (BFR) on neuromuscular, metabolic and hemodynamic variables. PubMed, Web of ScienceTM and Scopus databases were searched for the period from January 2000 to June 2019 and the analysis involved a critical content review. A total of 313 articles were identified, of which 271 were excluded and 35 satisfied the inclusion criteria. Twelve studies evaluated the acute effects and eight studies evaluated the chronic metabolic effects of AE + BFR. For the neuromuscular variables, three studies analyzed the acute effects of AE + BFR and nine studies analyzed the chronic effects. Only 15 studies were identified that evaluated the hemodynamic acute effects of AE + BFR. The analysis provided evidence that AE combined with BFR promotes positive acute and chronic changes in neuromuscular and metabolic variables, a greater elevation in hemodynamic variables than exercise alone, and a higher energy demand during and after exercise. Since these alterations were all well-tolerated, this method can be considered to be safe and feasible for populations of athletes, healthy young, obese, and elderly individuals.
Principles of the Guidance of Exploration for Orientation and Specification of Action

To control movement of any type, the neural system requires perceptual information to distinguish what actions are possible in any given environment. The behavior aimed at collecting this information, termed “exploration”, is vital for successful movement control. Currently, the main function of exploration is understood in the context of specifying the requirements of the task at hand. To accommodate for agency and action-selection, we propose that this understanding needs to be supplemented with a function of exploration that logically precedes the specification of action requirements with the purpose of discovery of possibilities for action—action orientation. This study aimed to provide evidence for the delineation of exploration for action orientation and exploration for action specification using the principles from “General Tau Theory. ” Sixteen male participants volunteered and performed a laboratory-based exploration task. The visual scenes of different task-specific situations were projected on five monitors surrounding the participant. At a predetermined time, the participant received a simulated ball and was asked to respond by indicating where they would next play the ball. Head movements were recorded using inertial sensors as a measure of exploratory activity. It was shown that movement guidance characteristics varied between different head turns as participants moved from exploration for orientation to exploration for action specification. The first head turn in the trial, used for action-orientation, showed later peaks in the velocity profile and harder closure of the movement gap (gap between the start and end of the head-movement) in comparison to the later head turns. However, no differences were found between the first and the final head turn, which we hypothesized are used mainly for action orientation and specification respectively. These results are in support of differences in the function and control of head movement for discovery of opportunities for action (orientation) vs. head movement for specification of task requirements. Both are important for natural movement, yet in experimental settings,orientation is often neglected. Including both orientation and action specification in an experimental design should maximize generalizability of an experiment to natural behavior. Future studies are required to study the neural bases of movement guidance in order to better understand exploration in anticipation of movement.
Microbiomes in Soils Exposed to Naturally High Concentrations of CO2 (Bossoleto Mofette Tuscany, Italy)

Direct and indirect effects of extremely high geogenic CO2 levels, commonly occurring in volcanic and hydrothermal environments, on biogeochemical processes in soil are poorly understood. This study investigated a sinkhole in Italy where long-term emissions of thermometamorphic-derived CO2 are associated with accumulation of carbon in the topsoil and removal of inorganic carbon in low pH environments at the bottom of the sinkhole. The comparison between interstitial soil gasses and those collected in an adjacent bubbling pool and the analysis of the carbon isotopic composition of CO2 and CH4 clearly indicated the occurrence of CH4 oxidation and negligible methanogenesis in soils at the bottom of the sinkhole. Extremely high CO2 concentrations resulted in higher microbial abundance (up to 4 × 109 cell g–1 DW) and a lower microbial diversity by favoring bacteria already reported to be involved in acetogenesis in mofette soils (i.e., Firmicutes, Chloroflexi, and Acidobacteria). Laboratory incubations to test the acetogenic and methanogenic potential clearly showed that all the mofette soil supplied with hydrogen gas displayed a remarkable CO2 fixation potential, primarily due to the activity of acetogenic microorganisms. By contrast, negligible production of acetate occurred in control tests incubated with the same soils, under identical conditions, without the addition of hydrogen. In this study, we report how changes in diversity and functions of the soil microbial community – induced by high CO2 concentration – create peculiar biogeochemical profile. CO2 emission affects carbon cycling through: (i) inhibition of the decomposition of the organic carbon and (ii) promotion of CO2-fixation via the acetyl-CoA pathway. Sites naturally exposed to extremely high CO2 levels could potentially represent an untapped source of microorganisms with unique capabilities to catalytically convert CO2 into valuable organic chemicals and fuels.
Mind the Map: Technology Shapes the Myeloid Cell Space

The myeloid cell system shows very high plasticity, which is crucial to quickly adapt to changes during an immune response. From the beginning, this high plasticity has made cell type classification within the myeloid cell system difficult. Not surprising, naming schemes have been frequently changed. Recent advancements in multidimensional technologies, including mass cytometry and single-cell RNA sequencing, are challenging our current understanding of cell types, cell subsets, and functional states of cells. Despite the power of these technologies to create new reference maps for the myeloid cell system, it is essential to put these new results into context with previous knowledge that was established over decades. Here we report on earlier attempts of cell type classification in the myeloid cell system, discuss current approaches and their pros and cons, and propose future strategies for cell type classification within the myeloid cell system that can be easily extended to other cell types.
Beamforming in LTE FDD for Multiple Antenna Systems

High data rate is still the most crucial factor in cellular systems, and with 5g approaching new techniques are studied to achieve higher bit rates. Using MIMO technology, the spatial domain was exploited through beamforming and multiplexing multiple users’ data together assured more spectrum efficiency which resulted in higher bit rates. Reciprocity based beamforming is feasible in TDD systems due to channel reciprocity assumption between uplink and downlink, the same is not true for FDD systems, as a consequence of using different frequencies between uplink and downlink. Nonetheless, FDD systems are widely deployed because of the existing spectrum assignments and earlier technologies. In addition, FDD systems have advantages such as greater coverage, lower latency over TDD systems. The thesis objective is to study the feasibility of applying beamforming in FDD systems. We investigate for appropriate techniques based on uplink channel measurements and study its performance for various conditions like Doppler shift, number of users, and also compare those results with beamforming in TDD. Results are generated by implementing LTE physical layer and a practical channel model in MATLAB. Mainly three techniques are implemented, all of these used reciprocity in term of Angle of Arrival between uplink and downlink for an FDD channel. The obtained results showed that channel reciprocity based TDD systems perform much better than channel non reciprocity based FDD system in terms of the number of users which can be beamformed with an acceptable Bit Error Rate (BER). Also, the used beamforming techniques showed around 50% improvement in overall capacity for one cell, when compared to FDD system with no beamforming applied.
Electrocatalysis of Oxygen Reduction Reaction on Shape-Controlled Pt and Pd Nanoparticles—Importance of Surface Cleanliness and Reconstruction

Shape-controlled precious metal nanoparticles have attracted significant research interest in the recent past due to their fundamental and scientific importance. Because of their crystallographic-orientation-dependent properties, these metal nanoparticles have tremendous implications in electrocatalysis. This review aims to discuss the strategies for synthesis of shape-controlled platinum (Pt) and palladium (Pd) nanoparticles and procedures for the surfactant removal, without compromising their surface structural integrity. In particular, the electrocatalysis of oxygen reduction reaction (ORR) on shape-controlled nanoparticles (Pt and Pd) is discussed and the results are analyzed in the context of that reported with single crystal electrodes. Accepted theories on the stability of precious metal nanoparticle surfaces under electrochemical conditions are revisited. Dissolution, reconstruction, and comprehensive views on the factors that contribute to the loss of electrochemically active surface area (ESA) of nanoparticles leading to an inevitable decrease in ORR activity are presented. The contribution of adsorbed electrolyte anions, in-situ generated adsorbates and contaminants toward the ESA reduction are also discussed. Methods for the revival of activity of surfaces contaminated with adsorbed impurities without perturbing the surface structure and its implications to electrocatalysis are reviewed.
Equine Stereotaxtic Population Average Brain Atlas With Neuroanatomic Correlation

There is growing interest in the horse for behavioral, neuroanatomic and neuroscientific research due to its large and complex brain, cognitive abilities and long lifespan making it neurologically interesting and a potential large animal model for several neuropsychological diseases. Magnetic resonance imaging (MRI) is a powerful neuroscientific research tool that can be performed in vivo, with adapted equine facilities, or ex-vivo in the research setting. The brain atlas is a fundamental resource for neuroimaging research, and have been created for a multitude animal models, however, none currently exist for the equine brain. In this study, we document the creation of a high-resolution stereotaxic population average brain atlas of the equine. The atlas was generated from nine unfixed equine cadaver brains imaged within 4 h of euthanasia in a 3-tesla MRI. The atlas was generated using linear and non-linear registration methods and quality assessed using signal and contrast to noise calculations. Tissue segmentation maps (TSMs) for white matter (WM), gray matter (GM) and cerebrospinal fluid (CSF), were generated and manually segmented anatomic priors created for multiple subcortical brain structures. The resulting atlas was validated and correlated to gross anatomical specimens and is made freely available at as an online resource for researchers (https://doi.org/10.7298/cyrs-7b51.2). The mean volume metrics for the whole brain, GM and WM for the included subjects were documented and the effect of age and laterality assessed. Alterations in brain volume in relation to age were identified, though these variables were not found to be significantly correlated. All subjects had higher whole brain, GM and WM volumes on the right side, consistent with the well documented right forebrain dominance of horses. This atlas provides an important tool for automated processing in equine and translational neuroimaging research.
Transcriptional Analysis of Human Skin Lesions Identifies Tryptophan-2,3-Deoxygenase as a Restriction Factor for Cutaneous Leishmania

Disease manifestation after infection with cutaneous Leishmania species is the result of a complex interplay of diverse factors, including the immune status of the host, the infecting parasite species, or the parasite load at the lesion site. Understanding how these factors impact on the pathology of cutaneous leishmaniasis (CL) may provide new targets to manage the infection and improve clinical outcome. We quantified the relative expression of 170 genes involved in a diverse range of biological processes, in the skin biopsies from patients afflicted with CL caused by infection with either L. major or L. tropica. As compared to healthy skin, CL lesions bear elevated levels of transcripts involved in the immune response, and conversely, present a significant downregulation in the expression of genes involved in epidermal integrity and arginine or fatty acid metabolism. The expression of transcripts encoding for cytotoxic mediators and chemokines in lesions was inversely correlated with the expression of genes involved in epidermal integrity, suggesting that cytotoxicity is a major mediator of CL pathology. When comparing the transcriptional profiles of lesions caused by either L. major or L. tropica, we found them to be very similar, the later presenting an aggravated inflammatory/cytotoxic profile. Finally, we identified genes positively correlated with the parasite load in lesions. Among others, these included Th2 or regulatory cytokines, such as IL4 or IL10. Remarkably, a single gene among our dataset, encoding for tryptophan-2,3-deoxygenase (TDO), presented a negative correlation with the parasite load, suggesting that its expression may restrict parasite numbers in lesions. In agreement, treatment of macrophages infected with L. major in vitro with a TDO inhibitor led to an increase in parasite transcripts. Our work provides new insights into the factors that impact CL pathology and identifies TDO as a restriction factor for cutaneous Leishmania.
Role of Microglial Cells in Alzheimer’s Disease Tau Propagation

Uncontrolled immune response in the brain contributes to the progression of all neurodegenerative disease, including Alzheimer’s disease (AD). Recent investigations have documented the prion-like features of tau protein and the involvement of microglial changes with tau pathology. While it is still unclear what sequence of events is causal, it is likely that tau seeding potential and microglial contribution to tau propagation act together, and are essential for the development and progression of degenerative changes. Based on available evidence, targeting tau seeds and controlling some signaling pathways in a complex inflammation process could represent a possible new therapeutic approach for treating neurodegenerative diseases. Recent findings propose novel diagnostic assays and markers that may be used together with standard methods to complete and improve the diagnosis and classification of these diseases. In conclusion, a novel perspective on microglia-tau relations reveals new issues to investigate and imposes different approaches for developing therapeutic strategies for AD.
Grammatical Gender Influences Semantic Categorization and Implicit Cognition in Polish

The influence of grammatical gender on cognitive processes is an important issue in contemporary psycholinguistics and language psychology, particularly in research concerning the relations between grammar and semantics. The extent of this effect is dependent on a given language’s gender system and its grammatical specifics. The aim of the presented research was to investigate grammatical gender effects in Polish – a Slavic language with three singular and two plural grammatical genders. In Experiment 1, triadic similarity judgments were used, and it turned out that the grammatical gender of nouns influenced perceived similarity of words in case of animals, but not inanimate objects or abstract concepts. In Experiment 2 we used a modified Implicit Association Test; results suggest that grammatical gender seems to be of implicit nature, as grammatical gender consistency influenced reaction times and the number of classification errors. In Experiment 3 participants assigned male and female voices to animals and inanimate objects, which were presented either as words or as pictures. Grammatical gender effects occurred for both animate and inanimate objects and were similar for verbal and visual stimuli. It turned out that in the Polish language the influence of grammatical gender may occur on the lexicosemantic level and the conceptual level, and concerns both animate and inanimate objects. Results are discussed in context of the similarity and gender and the sex and gender hypotheses.