Miracle-dz/UniFAR-FTUs huggingface dataset:
Understanding the Stiff-to-compliant Transition of the Meniscal Attachments by Spatial Correlation of Composition, Structure, and Mechanics.

Recently, the scientific community has shown considerable interest in engineering tissues with organized compositional and structural gradients to mimic hard-to-soft tissue interfaces. This effort is hindered by an incomplete understanding of the construction of native tissue interfaces. In this work, we combined Raman microscopy and confocal elastography to map compositional, structural, and mechanical features across the stiff-to-compliant interface of the attachments of the meniscus in the knee. This study provides new insight into the methods by which biology mediates multiple order of magnitude changes in stiffness over tens of microns. We identified how the nano- to meso-scale architecture mediates complex microscale transitional regions across the interface: two regions defined by chemical composition, five distinguished by structural features, and three mechanically distinct regions. We identified three major components that lead to a robust interface between soft tissue and bone: mobile collagen fiber units, a continuous interfacial region, and a local stiffness gradient. This tissue architecture allows for large displacements of collagen fibers in the attachments, enabling meniscal movement without localizing strains to the soft tissue-bone interface. The interplay of these regions reveals a method relying on hierarchical structuring across multiple length scales to minimize stress concentrators between highly dissimilar materials. These insights inspire new design strategies for synthetic soft tissue-to-bone attachments and biomimetic material interfaces.
Radiations phantom for handheld phones

When designing antennas for mobile communication systems such as GSM 1800, a need is recognized for analyzing the effect on antenna parameters from both the handset and the presence of the human body. To allow this analysis, both experimental and numerical techniques have been considered: measurements in an anechoic chamber and finite-difference time-domain (FD-TD) computation. By this way, the suitability of the FD-TD method and the influence of a torso plus hand phantom on two substantially different antennas operating at 1800 MHz have been investigated. The results indicate that the way to hold the mobile phone is really important, primarily the position of the hand on the handset and minor by the tilt angle of the handset.
The finger walker : a method to navigate virtual environments

Abstract : There are many factors which make virtual environment (VE) systems particularly useful for training applications. Not only can VE systems be easily reconfigured to simulate different real situations, but they can be used to create situations that could not exist in the real world but nonetheless are exceptionally effective in training. Within the general training area, work in this thesis focuses on training directed towards the acquisition of spatial knowledge. There are many cases in which spatial knowledge cannot be acquired in the actual environment, and the training must be accomplished by other means using a VE. A critical factor contributing to the acquisition of spatial knowledge is the method employed for moving around within the VE. Some methods of movement do not provide the user with any easily sensed measure of the amount of effort or work that would be associated with the movement in the real world. This thesis concentrates on the development of an interface that enables the user to "finger walk" through a VE. This interface makes use of a low friction pad that allows the user to finger walk "in place" and an electric field sensing system that monitors the position of the fingers on the pad. The user interface designed effectively tracks the user's movement along the surface of the pad for input into a VE.
Mobile Application for Adaptive Threshold Hunting in Transcranial Magnetic Stimulation

Application of transcranial magnetic stimulation (TMS) is expanding with many studies applying adaptive threshold hunting to determine a motor threshold (MT). In addition to being a measure of corticospinal excitability, the MT is used as a baseline stimulation intensity (SI) to which following investigative or modulatory SIs are referenced to. Currently available tools for determining MTs include system-integrated tools and third-party stand-alone software. System-integrated MT-tools are still rarely available and the stand-alone software usually demand a separate computer, and hence possess additional space-requirements. I introduce and validate a free Android-based mobile application (“ATH-tool”) for adaptive threshold hunting of the MT. The objective is to allow for a simple and validated recording of MTs with sharing capabilities for logs. For comparison, I applied Motor Threshold Assessment Tool 2.0, to compare the MT-values determined with the new application, as it applies closely the same routine. Computational validation with known true threshold values confirmed that the new application captured the true MT at high precision (error ≤ 0.9%). Previously published data on motor evoked potentials (MEPs) were used to simulate realistic response occurrence by considering experimental data from 15 healthy subjects at different stimulation intensities. The MTs of the different methods agreed well (ICC ≥ 0.971, ${p} < 0.001$ ). There was no significant difference between the MTs determined with the different methods ( $p \ge0.151$ ). The novel mobile application should make it easier for researchers and clinicians to determine MTs and log the results.
ActivEarring: Spatiotemporal Haptic Cues on the Ears

The symmetric configuration and the sensitivity of ears in addition to the long tradition of earrings as adornment open up the possibility for smart ear-worn devices. Taking advantage of these attributes, past research mostly focused on creating novel unobtrusive sensing input devices and auditory displays placed on the ear. Meanwhile, the tactile sensitivity of the ear has long been overshadowed by its auditory capacity, presenting the opportunity to investigate how ears can be exploited for unobtrusive tactile information transfer. With three studies and a total of 38 participants, we suggest the design of ActivEarring, a ear-worn device capable of imparting information by stimulating six different locations on both ears. We evaluated the performance of ActivEarring in a semi-realistic mobile condition and its practical use for information transfer with spatiotemporal patterns. Finally, we demonstrate that ActivEarring can be incorporated in common jewelry design, and present three applications that illustrate promising usage scenarios.
Treatment and recurrence of traumatic versus idiopathic benign paroxysmal positional vertigo: a meta-analysis

Abstract Background: So far, there has been a controversy surrounding repositioning difficulty and recurrence rate between traumatic benign paroxysmal positional vertigo (t-BPPV) and idiopathic BPPV (i-BPPV). Objectives: This meta-analysis was aimed to explore whether or not the differences between t-BPPV and i-BPPV in the repositioning difficulty and recurrence rate existed. Material and methods: A literature search was performed in the databases including Pubmed, Embase, CENTRAL, which completed in 21 January 2019, with no restriction of publication language. Relative risk (RR) of number of repositioning maneuvers and the recurrence rate was calculated with its 95% confidence interval. Sensitive analysis was performed simultaneously. Results: Six retrospective cohort studies were included in our meta-analysis, including 865 t-BPPV patients and 3027 i-BPPV patients. All studies were high quality according to Newcastle-Ottawa Scale (NOS) assessment. Patients with t-BPPV required more repositioning maneuvers for resolution than those with i-BPPV (RR = 3.27, 95% CI = 1.88–5.69, p < .0001), and the recurrence rate of t-BPPV was higher than that of i-BPPV (RR = 2.91, 95% CI = 2.04–4.14, p < .00001). Conclusions and significance: Compared with i-BPPV, patients with t-BPPV require more repositioning maneuvers to resolve, and the recurrence of t-BPPV was more frequent.
Deconstructing the Tower of London : resolution, alternatives and executive function.

Although widely employed as an executive task, the performance demands of the Tower of London task (TOL) are not well understood. The aim of this Thesis is to determine what TOL measures and seven studies are included that illustrate its performance demands. Much of the work is experimental and TOL is explored via a novel verification paradigm in which participants make speeded judgements about whether a demonstrated move is optimal or suboptimal. The deconstruction of the task to the level of the individual move indicated that the number of moves until a disk was placed in its goal position (resolution) and the number of legal alternative moves there were predicted performance. When the task was reconstructed to its original form where complete problems were issued, these performance demands continued to predict planning time, execution time and accuracy. These demands were characterised as involving a depth search (resolution) and a breadth search (alternatives) of the problem space. Several studies included individual difference measures or the dual-task paradigm to determine the cognitive processes that were involved in performance. It was argued that spatial processes are involved to manipulate disks in memory and it was argued that the resolution demands were closely related to planning and the alternative move demands to inhibition. These performance characteristics are involved in many real world tasks and may elicit the deficits observed in clinical samples. One study was presented in which the performance of older adults was compared to younger adults. It was shown that older adults had a particular deficit in their ability to consider alternative moves; a similar TOL deficit might be observed in other dysexecutive populations. This thesis provides recommendations and guidelines for using TOL in research and stresses the importance of the items used on performance.
Giant Poisson's Effect for Wrinkle‐Free Stretchable Transparent Electrodes

The next generation of flexible electronics will require highly stretchable and transparent electrodes, many of which consist of a relatively stiff metal network (or carbon materials) and an underlying soft substrate. Typically, such a stiff–soft bilayer suffers from wrinkling or folding when subjected to strains, causing high surface roughness and seriously deteriorated optical transparency. In this work, a network with a giant effective Poisson's ratio on a soft substrate is found to be under biaxial tension upon deformation, and thus does not wrinkle or fold, but maintains smooth surfaces and high transparency. Soft tactile sensors employing such network electrodes exhibit high transparency and low fatigue over many stretching cycles. Such a giant Poisson's ratio has the same effect in other systems. This work offers a new understanding of surface instabilities and a general strategy to prevent them not only in flexible electronics, but also in other materials and mechanical structures that require flat surfaces.
Differences in the Binding Affinity of an HIV-1 V2 Apex-Specific Antibody for the SIVsmm/mac Envelope Glycoprotein Uncouple Antibody-Dependent Cellular Cytotoxicity from Neutralization

Here we show that PGT145, a potent broadly neutralizing antibody to HIV-1, directs the lysis of SIV-infected cells by antibody-dependent cellular cytotoxicity but does not neutralize SIV infectivity. This represents the first instance of cross-reactivity of an HIV-1 Env-specific antibody with SIVsmm/mac Env and reveals that antibody binding affinity can differentiate sensitivity to ADCC from neutralization. ABSTRACT As a consequence of their independent evolutionary origins in apes and Old World monkeys, human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency viruses of the SIVsmm/mac lineage express phylogenetically and antigenically distinct envelope glycoproteins. Thus, HIV-1 Env-specific antibodies do not typically cross-react with the Env proteins of SIVsmm/mac isolates. Here we show that PGT145, a broadly neutralizing antibody to a quaternary epitope at the V2 apex of HIV-1 Env, directs the lysis of SIVsmm/mac-infected cells by antibody-dependent cellular cytotoxicity (ADCC) but does not neutralize SIVsmm/mac infectivity. Amino acid substitutions in the V2 loop of SIVmac239 corresponding to the epitope for PGT145 in HIV-1 Env modulate sensitivity to this antibody. Whereas a substitution in a conserved N-linked glycosylation site (N171Q) eliminates sensitivity to ADCC, a lysine-to-serine substitution in this region (K180S) increases ADCC and renders the virus susceptible to neutralization. These differences in function correlate with an increase in the affinity of PGT145 binding to Env on the surface of virus-infected cells and to soluble Env trimers. To our knowledge, this represents the first instance of an HIV-1 Env-specific antibody that cross-reacts with SIVsmm/mac Env and illustrates how differences in antibody binding affinity for Env can differentiate sensitivity to ADCC from neutralization. IMPORTANCE Here we show that PGT145, a potent broadly neutralizing antibody to HIV-1, directs the lysis of SIV-infected cells by antibody-dependent cellular cytotoxicity but does not neutralize SIV infectivity. This represents the first instance of cross-reactivity of an HIV-1 Env-specific antibody with SIVsmm/mac Env and reveals that antibody binding affinity can differentiate sensitivity to ADCC from neutralization.
Multi-Omics Analysis Reveals Up-Regulation of APR Signaling, LXR/RXR and FXR/RXR Activation Pathways in Holstein Dairy Cows Exposed to High-Altitude Hypoxia

Simple Summary Blood has been widely collected and analyzed for diagnosing and monitoring diseases in human beings and animals. A range of plasma proteins and peptides were set as biomarkers for pathological and physiological status. Previous researchers have explored how humans, pigs, dogs, and horses adapt to hypoxia at high altitudes. Additionally, the mechanism of hypoxia adaptation in human, mice, and shrimp was studied by proteomics. However, information on the adaptation mechanism of Holstein cows introduced to high altitudes is limited. The present study was conducted to the adaptation mechanism of Holstein dairy cows to high-altitude hypoxia by miRNA microarray analysis and the isobaric tags for relative and absolute quantitation (iTRAQ) iTRAQ technology. Based on the obtained results, Holstein dairy cows transported to Nyingchi may adapt to the high-altitude hypoxia through regulation of inflammatory homeostasis by up-regulating the acute phase response (APR) APR and activation of the liver X receptor/retinoid X receptor (LXR/RXR)LXR/RXR and farnesoid X receptor/ retinoid X receptor (FXR/RXR) FXR/RXR pathways. Abstract Changes in the environment such as high-altitude hypoxia (HAH) high-altitude hypoxia can lead to adaptive changes in the blood system of mammals. However, there is limited information about the adaptation of Holstein dairy cows introduced to high-altitude areas. This study used 12 multiparous Holstein dairy cows (600 ± 55 kg, average three years old) exposed to HAH conditions in Nyingchi of Tibet (altitude 3000 m) and HAH-free conditions in Shenyang (altitude 50 m). The miRNA microarray analysis and iTRAQ proteomics approach (accepted as more suitable for accurate and comprehensive prediction of miRNA targets) were applied to explore the differences in the plasma proteomic and miRNA profiles in Holstein dairy cows. A total of 70 differential miRNAs (54 up-regulated, Fold change (FC) FC > 2, and 16 down-regulated, FC < 0.5) and 226 differential proteins (132 up-regulated, FC > 1.2, and 94 down-regulated, FC < 0.8) were found in the HAH-stressed group compared with the HAH-free group. Integrative analysis of proteomic and miRNA profiles demonstrated the biological processes associated with differential proteins were the immune response, complement activation, protein activation, and lipid transport. The integrative analysis of canonical pathways were most prominently associated with the APR signaling (z = 1.604), and LXR/RXR activation (z = 0.365), and FXR/RXR activation (z = 0.446) pathways. The current results indicated that Holstein dairy cows exposed to HAH could adapt to high-altitude hypoxia by up-regulating the APR, activating the LXR/RXR and FXE/RXR pathways.
Group-based, individualized, comprehensive core stability and balance intervention provides immediate and long-term improvements in walking in individuals with multiple sclerosis: A randomized controlled trial.

OBJECTIVES Walking impairments are common in individuals with multiple sclerosis. Trunk control is a prerequisite for walking; however, knowledge regarding whether core stability and balance training influence walking is limited. This study aimed to investigate the immediate and long-term effects of a group-based, individualized, comprehensive core stability and balance intervention (GroupCoreDIST) compared with those of standard care on walking. METHODS This assessor-blinded, prospective randomized controlled trial included 80 participants (Expanded Disability Status Scale scores 1-6.5) randomly allocated to GroupCoreDIST, conducted in groups of three for 60 min three times per week for 6 weeks (18 sessions) or standard care (n = 40/40). One participant attended no posttests, leaving 79 subjects for intention-to-treat analysis. The assessments were performed at baseline and at Weeks 7, 18, and 30. Outcomes included the 2-min walk test (2MWT), 10-m walk test-preferred/fast/slow speed (10MWT), Multiple Sclerosis Walking Scale-12 (MSWS-12), Patient Global Impression of Change-walking (PGIC-walking), Rivermead Visual Gait Assessment (RVGA), and ActiGraphsWgt3X-BT activity monitors (ActiGraph). The statistical analyses included repeated-measures mixed models performed in IBM SPSS Version 24. RESULTS There were no significant between-group differences in the outcome measurements at baseline. The mean differences between groups were significant at all follow-up time points in favour of GroupCoreDIST for the 2MWT, 16.7 m at 7 weeks (95% CI [8.15, 25.25], 15.08 m at 18 weeks (95% CI [6.39, 23.77]) and 16.38 m at 30 weeks (95% CI [7.65, 25.12]; and the PGIC-walking, 0.89 points at 7 weeks (95% CI [1.34, 0.45]), 0.97 points at 18 weeks (95% CI [1.42, 0.52]), and 0.93 points at 30 weeks (95% CI [1.39, 0.48]; all p ≤ .001). The 10MWT-fast speed and the MSWS-12 showed significant between-group differences at 7 and 18 weeks and the RVGA at 7 weeks. No between-group differences were found regarding activity level (ActiGraph) or the 10MWT-preferred or slow speed. CONCLUSION Compared with standard care, GroupCoreDIST significantly improved walking immediately after the intervention for up to 24 weeks of follow-up.
Outcomes of endovascular treatment of renal arterial stenosis in transplanted kidneys

ABSTRACT Objective To evaluate the effectiveness and outcomes of endovascular treatment of TRAS with PTA. Materials and Methods We searched our prospectively collected database looking at cases of TRAS between January 2005-December 2011. CCT was the gold-standart for diagnosis of TRAS. Parameters analysed comprised technical aspects, arterial blood pressure variation, and renal function. A minimum follow-up of 24 months was considered. Results Of the 2221 renal transplants performed in the selected period, 22 (0.9%) patients were identified with TRAS. Fourteen (63.6%) were male and mean age was 377±14.8years (12-69). Kidney graft was from deceased donnors in 20 (80%) cases. On doppler evaluation, mean blood flow speed after transplantation, at TRAS diagnosis and after TAP was 210.6±99.5, 417±122.7 and 182.5±81.6mL/sec, respectively (p<0.001). For SBP and DBP, there was a significant difference between between pre-intervention and all post-treatment time points (p<0.001). After 1 month of the procedure, there was stabilization of the Cr level with a significant difference between mean Cr levels along time (p<0.001). After a mean follow-up of 16±4.2 (3-24) months, overall success rate was 100%. Conclusions Endovascular treatment with PTA/stenting is a safe and effective option for managing TRAS, ensuring the functionality of the graft and normalization of blood pressure and renal function.
On the Performance of PF, MLWDF and EXP/PF algorithms in LTE

This paper explores the performance of three packet scheduling algorithms, namely, Proportional Fair (PF) algorithm, Exponential/Proportional Fair (EXP/PF) algorithm and Maximum Largest Weighted Delay First (MLWDF), from the real time traffic perspectives. Simulation results showed that in the downlink of the 3GPP LTE system, the MLWDF outperforms the PF and the EXP/PF algorithms in terms of packet throughput, packet-loss ratio, packet latency, fairness index and total cell spectral efficiency.
Comparative Effectiveness of Certolizumab Pegol, Abatacept, and Biosimilar Infliximab in Patients With Rheumatoid Arthritis Treated in Routine Care: Observational Data From the Danish DANBIO Registry Emulating a Randomized Trial

Nationwide Danish guidelines regarding rheumatoid arthritis (RA) patients initiating biologic treatment (i.e., biologic disease‐modifying antirheumatic drugs [DMARDs]) are issued on an approximately annual basis. For biologics‐naive patients treated with concomitant methotrexate, mandatory medications included certolizumab pegol (CZP; year 2013–2014, recommended compliance 80%), abatacept (ABA; 2014–2015, 80%), and biosimilar infliximab (CT‐P13; 2015–2016, 50%). We hypothesized that these guidelines could be perceived as a surrogate randomization tool in which calendar period rather than patient‐specific factors defined the choice of the biologic DMARD. We undertook this study to assess compliance with guidelines (supporting the assumption of surrogate randomization) and to compare the effectiveness of CZP, ABA, and CT‐P13 in patients treated according to guidelines.
Epidemiological and Immunological Features of Influenza Viruses in Hospitalized Children with Influenza Illness in Hangzhou

Abstract Objectives: We evaluated the epidemiological features and various inflammatory markers in hospitalized children with influenza virus infection in China. Methods: The real-time RT-PCR assay was performed for detection and genotyping of influenza A and B virus. Th1/Th2 cytokines, WBC, and CRP were determined in influenza virus positive children. Results: H1N1 and Yamagata were the prevalent genotypes of influenza A and B virus in Hangzhou, respectively. IL-2, IL-10, and CRP were significantly increased and IFN-γ was decreased in children with severe Influenza A virus infection, and TNF-α and IFN-γ levels were found to be significantly lower in children with severe Influenza B virus infection. Conclusion: Increased IL-2, IL-10, and CRP with decreased IFN-γ may indicate a severe influenza A virus infection, and decreased TNF-α and IFN-γ may indicate a severe influenza B virus infection in children.