Miracle-dz/UniFAR-FTUs huggingface dataset:
A randomized controlled trial of the use of self-help materials in addition to standard general practice treatment of depression compared to standard treatment alone

Background. The purpose of the study was to examine whether the addition of a brief individual self-help package to standard primary-care treatment of depression with antidepressants is associated with any additional improvements in clinical outcome. Method. Individuals with major depressive disorder who were prescribed an antidepressant were recruited through their general practitioner (GP) and allocated randomly to standard treatment alone or standard treatment plus self-help. Assessments of symptoms, social adjustment, global functioning, satisfaction with treatment and knowledge about the management of the disorder were completed at three time points over 26 weeks. Results. One hundred and twelve individuals agreed to participate and 96 met criteria for inclusion in the randomized controlled trial. Subjects in both treatment conditions improved substantially over the study period; the mean Beck Depression Inventory (BDI) score fell from 27·3 to 13·9 in the intention-to-treat analysis. There were no between group differences in outcome on any of the primary outcome measures, nor did these approach even marginal significance. Patients and GPs were highly satisfied with the self-help programme, and the intervention as compared to the control group reported significantly greater improvements in knowledge about depression and satisfaction with information received about depression. Conclusions. An individualized self-help package improved perceived knowledge about depression but did not have identifiable effects on outcome when offered to patients treated in primary care. The study was sufficiently well powered to detect relatively small effects.
Model Predictive Control Design: New Trends and Tools

Model-based design is well recognized in industry as a systematic approach to the development, evaluation, and implementation of feedback controllers. Model predictive control (MPC) is a particular branch of model-based design: a dynamical model of the open-loop process is explicitly used to construct an optimization problem aimed at achieving the prescribed system's performance under specified restrictions on input and output variables. The solution of the optimization problem provides the feedback control action, and can be either computed by embedding a numerical solver in the real-time control code, or pre-computed off-line and evaluated through a lookup table of linear feedback gains. This paper reviews the basic ideas of MPC design, from the traditional linear MPC setup based on quadratic programming to more a advanced explicit and hybrid MPC, and highlights available software tools for the design, evaluation, code generation, and deployment of MPC controllers in real-time hardware platforms
Intrusion Detection System for IEC 60870-5-104 based SCADA networks

Increased complexity and interconnectivity of Supervisory Control and Data Acquisition (SCADA) systems in Smart Grids potentially means greater susceptibility to malicious attackers. SCADA systems with legacy communication infrastructure have inherent cyber-security vulnerabilities as these systems were originally designed with little consideration of cyber threats. In order to improve cyber-security of SCADA networks, this paper presents a rule-based Intrusion Detection System (IDS) using a Deep Packet Inspection (DPI) method, which includes signature-based and model-based approaches tailored for SCADA systems. The proposed signature-based rules can accurately detect several known suspicious or malicious attacks. In addition, model-based detection is proposed as a complementary method to detect unknown attacks. Finally, proposed intrusion detection approaches for SCADA networks are implemented and verified via Snort rules.
‘It's off to work we go!’ Person–environment fit and turnover intentions in managerial and administrative mining personnel

Purpose. Person–environment fit asserts that incompatibility between an employee and aspects of their work environment is more likely to lead to occupational stress. The aim of this study was to investigate the impact that varying levels of person–environment fit had on key criterion outcomes including work engagement, work-related wellbeing and turnover intentions in a unique sample of managerial and administrative mining personnel. Method. An online self-report survey was distributed to an Australian mining organization by the company’s Chief Executive Officer. Anonymous survey links were sent to staff, of which 118 participants responded. The survey consisted of previously validated measures. Results. Hierarchical multiple regression analyses revealed significant relationships between abilities–demand fit, needs–supply fit and work engagement. Additionally, work-related wellbeing was significantly associated with increased person–organization fit and needs–supply fit. However, only needs–supply fit had a significant negative relationship with turnover intentions. Needs–supply fit significantly predicted all criterion variables. Conclusions. This study found that personal need fulfilment through work-related activities had the most significant impact on work-related wellbeing and work engagement. Personal need fulfilment through work also produced the most significant negative relationship with turnover intentions.
Composition, proteolysis indices and coagulating properties of ewe milk as affected by bulk tank somatic cell count

The aim of this study was to assess the effect of ovine bulk tank somatic cell count (BTSCC) on composition, proteose-peptone (p-p) content and casein fractions as indicating parameters for proteolysis and coagulating properties of milk. A total of 97 samples of bulk tank milk from Manchega breed ewe flocks were grouped according to somatic cell count (SCC) into four classes: fewer than 500 000 cells/ml, from 500 000 to 10 00 000 cells/ml, from 10 00 000 to 15 00 000 and more than 15 00 000 cells/ml. The casein : protein ratio and lactose content decreased with BTSCC. Proteolysis increased with BTSCC, causing a drop in β-casein and an increase in the γ-caseins from a concentration of 500 000 cells/ml. Regarding coagulation behaviour, the rennet clotting time (RCT) and firming time (k20) rose from 10 00 000–15 00 000 cells/ml of milk. The results showed that the impairment of milk quality and milk ability to make cheese as affected by intramammary infection (IMI) can be inferred from the bulk tank milk of flocks with poor udder health.
Relationships Among Herd Life, Milk Production, and Calving Interval

Abstract Whether to select for longer life in the herd or shorter calving interval depends on the genetic and phenotypic relationships among herd life, amount of milk in first lactation, and calving interval. Herd life and average calving interval are essentially phenotypically uncorrelated. The phenotypic and genetic correlations of herd life and milk in first lactation ranged from . 19 to . 25 and from . 54 to . 77, respectively. The phenotypic correlation of average calving interval and milk in first lactation ranged from . 19 to . 21. Estimates of the heritability of herd life ranged from . 05 to . 14. This heritability was reduced by 30% when the influence of milk in first lactation was eliminated. Selection of females for longer herd life or shorter calving interval would not be advantageous, but some consideration of the herd life of half-sisters and close ancestors could be of value in choosing young sires for testing.
An Intron Is Required for Dihydrofolate Reductase Protein Stability*

We compared the expression of dihydrofolate reductase minigenes with and without an intron. The levels of protein were significantly higher in the presence of dihydrofolate reductase intron 1. However, mRNA levels in both constructs were comparable. In addition, the RNA transcribed from either construct was correctly polyadenylated and exported to the cytoplasm. The intron-mediated increase in dihydrofolate reductase protein levels was position-independent and was also observed when dihydrofolate reductase intron 1 was replaced by heterologous introns. The translational rate of dihydrofolate reductase protein was increased in transfectants from the intron-containing minigene. In addition, the protein encoded by the intronless construct was unstable and subject to lysosomal degradation, thus showing a shorter half-life than the protein encoded by the intron-containing minigene. We conclude that an intron is required for the translation and stability of dihydrofolate reductase protein.
An improved forward I-V method for nonideal Schottky diodes with high series resistance

Two methods are described to obtain the value of the series resistance<tex>(R)</tex>of a Schottky diode from its forward I-V characteristic. The value of<tex>R</tex>is then used to plot the curve ln (<tex>I</tex>) versus<tex>V_{D} (= V - IR)</tex>which becomes a straight line even if ln<tex>(I)</tex>versus<tex>V</tex>does not. The ideality factor<tex>n</tex>and the Schottky-barrier height<tex>\Phi_{B0}</tex>of the diode then follow from the standard procedure. The main advantages of the methods are: 1) a linear regression can be used to calculate the value of<tex>R</tex>, 2) many data points are used over the whole data range which raises the accuracy of the results, and 3) the validity of constant<tex>R</tex>assumption can be checked by the linearity of the ln<tex>(I)</tex>versus V<inf>D</inf>curve. The methods are illustrated on the experimental data of a real diode.
Real- Time Tracking for Multiple Objects Based on Implementation of RGB Color Space in Video

Various algorithms based on image processing techniques have been used to detect and track objects in video surveillance systems. In this paper, followed by color RGB for multiple objects is present. To do this, real-time tracking algorithm is proposed for objects navigate and identify current positions and movements, because each object has a color with label on top. RGB color space is used to calculate the threshold values of each color. It is for example, video surveillance applications where cameras and other sources of information are used to monitor the activities of a sensitive site. Threshold values can be defined according to the object to track. Linear model is applied to the color discrimination. To remove unwanted objects to executives, morphological transformation is applied on the image binary and technical Blob analysis is then used to facilitate the detection of object. Our proposed algorithm is capable of tracking objects in the format full-frame (640 x 480 pixels) at rate (50 images per second). High performance robustness and in real time is confirmed by experiments.
Cavitation detection with subharmonic emissions by low intensity sustaining ultrasound

Control of acoustic cavitation by ultrasound pulse wave has been investigated recently. Cavitation detection is an important factor for the cavitation control. In this study, subharmonic detection which has been used to detect the acoustic cavitation in continuous sonication is applied to pulsed ultrasound sequence using low intensity sustaining ultrasound. The sustaining ultrasound follows just after the high intensity ultrasound pulse. The power of the sustaining ultrasound is low enough to avoid cavitation inception by itself. When the cavitating microbubbles are generated and grow to the certain size by the high intensity pulsed ultrasound, the sustaining ultrasound prevents the dissolution due to rectified diffusion. Finally, the bubbles can grow enough to emit subharmonic acoustic pressure. With this method, the cavitation generated by the pulsed ultrasound was clearly detected.
Lactic Acidosis Rates in Type 2 Diabetes

OBJECTIVE To provide a context for the interpretation of lactic acidosis risk among patients using metformin, we measured rates of lactic acidosis in patients with type 2 diabetes before metformin was approved for use in the U.S. RESEARCH DESIGN AND METHODS Using electronic databases of hospital discharge diagnoses and laboratory results maintained by a large, nonprofit health maintenance organization (HMO), we identified possible lactic acidosis events in three geographically and racially diverse populations with type 2 diabetes. We then reviewed hard-copy clinical records to confirm and describe each event and determine its likely cause(s). RESULTS From <41,000 person-years of experience, we found four confirmed, three possible, and three borderline cases of lactic acidosis. In each case, we identified at least one severe medical condition that could have caused the acidosis. The annual confirmed event rate is similar to published rates of metformin-associated lactic acidosis. CONCLUSIONS Lactic acidosis occurs regularly, although infrequently, among persons with type 2 diabetes, at rates similar to its occurrence among metformin users. The medical conditions with which both metformin-associated and naturally occurring lactic acidosis cooccur are also its potential causes. The observed association between metformin and lactic acidosis may be coincidental rather than causal. This possibility merits further study.
Stochastic Small-Signal Stability Analysis of Grid-Connected Photovoltaic Systems

As the penetration level of photovoltaic (PV) generators into the grid is rapidly increasing, the effect of a variable PV power output on the stability of power systems cannot be ignored. Due to the stochastic characteristics of PV power generation, deterministic analysis approaches are not able to fully reveal the impact of high-level PV integration. This paper investigates the impact of the stochastic PV generation on the dynamic stability of grid-connected PV systems by using a probabilistic small-signal analysis approach. The sensitivity of the critical eigenvalue to the variation of solar irradiance is obtained. With the knowledge of the sensitivity relationship and the statistics of solar irradiance data, the probability density function (pdf) of the real part of the critical eigenvalue is approximated by Gram-Charlier expansion. This pdf is then used to calculate the probability of the stochastic small-signal stability of a power system. The impacts of important system parameters on the stochastic stability of the system are also analyzed. It has been found that these system parameters can significantly affect the stochastic stability of the system. Results of Monte Carlo and time-domain simulations of the grid-connected system verify the effectiveness of the proposed stochastic stability analysis method.
Functional reconstitution of KCl‐evoked, Ca2+‐dependent acetylcholine release system in Xenopus oocytes microinjected with presynaptic plasma membranes and synaptic vesicles

We have developed a new method for the generation of functionally active presynaptic chimeras in Xenopus laevis oocytes. Frog oocytes injected with presynaptic subcellular fractions extracted from the electric organ of Torpedo marmorata release acetylcholine in a calcium‐dependent manner upon chemical stimulation. Neither oocytes injected without presynaptic plasma membranes nor oocytes injected with ghost erythrocyte plasma membrane instead of presynaptic plasma membrane release acetylcholine. This suggests that specific presynaptic components necessary for KCl‐evoked, Ca2+‐dependent acetylcholine release become functionally integrated in the Xenopus laevis oocytes. Moreover, rhodaminated presynaptic plasma membranes and the synaptic vesicle protein synaptophysin are detected on the oocyte surface by fluorescence or immunofluorescence, respectively, showing that the injected presynaptic components are incorporated into the membrane of the frog oocyte. Furthermore, Botulinum neurotoxin type A, a specific blocker of acetylcholine release in the neuromuscular junction, inhibits the neurotransmitter release from the chimerical oocytes. This suggests that targets for toxin action are also functionally incorporated in the oocyte upon injection of membranous presynaptic components. Our results show that oocytes injected with presynaptic components behave as cholinergic nerve ending chimeras, at least in terms of neurotransmitter release and toxin targets. The system bypasses some problems associated with messenger RNA expression because not only proteins, but native presynaptic components are incorporated. This new technique may provide a useful approach for electrophysiological and pharmacological studies in order to characterize the synaptic transmission. © 1996 Wiley‐Liss, Inc.
A comparison of metabolite extraction strategies for 1H‐NMR‐based metabolic profiling using mature leaf tissue from the model plant Arabidopsis thaliana

Metabolite analysis is recognized as an important facet of systems biology, however complete metabolome characterization has not been realized due to challenges in sample preparation, inherent instrumental limitations and the labor intensive task of data interpretation. This work aims to compare several commonly used metabolite extraction strategies for their effect on the 1H nuclear magnetic resonance (NMR) metabolic profile of extracts of the model plant Arabidopsis thaliana. Extractions were carried out on aliquots from a pool of homogenized plant tissue using CD3CN/D2O, buffered D2O, perchloric acid in D2O, CD3OD/D2O and CD3OD/D2O/CDCl3 as the extraction solvents. The effects of lyophilization as a sample pretreatment, solvent evaporation and extract fractionation for removal of interfering species were studied. Representative spectra are presented for qualitative interpretation. Analytical reproducibility was evaluated by principal components analysis. Perchloric acid facilitated acid‐catalyzed cleavage of sucrose, further complicating biological interpretation of the resulting metabolite profile. The solvent system CD3OD/D2O/CDCl3 gave the least reproducible results in our hands. D2O extracts suffered from poor stability probably due to contamination by soluble enzymes, which were not denatured in this solvent. CD3CN/D2O extracts showed greater stability than D2O alone, but problems were encountered due to degradation of 1H NMR spectral resolution during lengthy acquisitions due to partial phase separation. In addition, this solvent system produced spectra with significant contamination by lipids that obscured spectral regions containing the resonances of the aliphatic amino acids. These problems were solved by speedvacuuming the CD3CN/D2O extract and reconstituting in D2O solution. Copyright © 2009 John Wiley & Sons, Ltd.
V-index an index based on consistent researcher productivity

In the current era, tremendous amount of scientific research work is published by thousands of researchers annually. Different methods have been proposed for researcher productivity indexing based on quantity and quality of publications. Unfortunately, none of them considered the variation among the number of citations received by a researcher for his papers. In this paper, a novel method named Variation-Index (v-index) is proposed to handle this issue. It will consider variation in number of citations received by the researcher's publications. V-index considers the consistency in citations of researcher's publication in addition to their number of publications (quantity) and number of citations (quality) for indexing. Experimental results show the effectiveness of our proposed v-index over the existing state of the art indexing methods. This citation variation enhancement is quite general and can be merged in any of the existing indexing measures with ease.
Three-Stage CMOS OTA for Large Capacitive Loads With Efficient Frequency Compensation Scheme

A simple compensation strategy, which employs passive components only, is adopted to design a three-stage operational transconductance amplifier (OTA) suitable for driving high capacitive loads. Compared to the classical nested Miller compensation technique, the new solution exploits two additional resistors and allows a reduction in the values of the compensation capacitors of about an order of magnitude. The OTA was fabricated using 0.35-mum CMOS technology and exhibits a 1.4-MHz gain-bandwidth with a load of 500 pF
Gender differences in usage, satisfaction, self-efficacy and performance of blogging

Introduction Studies reported that more than half of blog users are female (Henning, 2003); most of their content was journal-type posts. Female users update more frequently and use blogs more than male users. Herring and Paolillo (2006) indicated that males like to talk about cars, sports, computers and so on, and females like to talk about gossip. In terms of vocabulary use, the researchers discovered that female users usually use words such as sorry, appreciate or thankful; male users usually use aggressive words and sometimes are rude (Eckert & McConnell-Ginet, 2003; Herring, 1993).
Validity and Reliability of the Secondary Traumatic Stress Scale—Chinese Version

Objectives To test the validity and reliability of the Secondary Traumatic Stress Scale—Chinese version in clinical nurses. Methods According to the translation principles of the Brislin Scale, the original scale was translated, back translated and cross-culturally adapted to form the Chinese version of the Secondary Traumatic Stress Scale. Nurses in three general hospitals in Changsha, Hunan province were surveyed by convenient sampling method from July 2020 to September 2021. Exploratory factor analysis, confirmatory factor analysis, content validity and criterion validity was used to evaluate the validity of the scale. Internal consistency Cronbach's α coefficient, split-half reliability and test-retest reliability were used to evaluate the reliability of the scale. Results A total of 678 nurses were included in the study. There were 460 people in sample 1 and 218 people in sample 2. Two common factors were extracted by exploratory factor analysis. The cumulative contribution was 65.560%. The two-factor structure model was good (χ2/df = 3.137, CFI = 0.928, IFI = 0.929, GFI = 0.842, TLI = 0.917, RMSEA = 0.099). The I-CVI of the scale was 0.8–1.0. The S-CVI/Ave was 0.94. The Cronbach's alpha coefficient is 0.956. The broken half reliability is 0.920. The retest reliability is 0.910. Conclusion This study identified two components of the Secondary Traumatic Stress Scale—Chinese version, which has 2 dimensions and 17 items. With good validity and reliability, it is suitable for the assessment of secondary traumatic stress among clinical nurses in the Chinese context.