Miracle-dz/UniFAR-FTUs huggingface dataset:
ATAXIC: An Algorithm to Quantify Transcriptomic Perturbation Heterogeneity in Single Cancer Cells

The single-cell RNA sequencing (scRNA-seq) has recently been widely utilized to quantify transcriptomic profiles in single cells of bulk tumors. The transcriptomic profiles in single cells facilitate the investigation of intratumor heterogeneity that is unlikely confounded by the nontumor components. We proposed an algorithm (ATAXIC) to quantify the heterogeneity of transcriptomic perturbations (TPs) in single cancer cells. ATAXIC calculated the TP heterogeneity level of a single cell based on the standard deviations of the absolute z-scored gene expression values for tens of thousands of genes, reflecting the asynchronous degree of transcriptomic alterations relative to the central (mean) tendency. By analyzing scRNA-seq datasets for eight cancer types, we revealed that ATAXIC scores were likely to correlate positively with the enrichment scores of various proliferation and oncogenic signatures, DNA damage repair, treatment resistance, and unfavorable phenotypes and outcomes in cancer. The ATAXIC scores varied among different cancer types, with lung cancer and melanoma having the lowest average scores and clear cell renal cell carcinoma having the highest average scores. The low TP heterogeneity in lung cancer and melanoma could bestow relatively higher response rates to immune checkpoint inhibitors on both cancer types. In conclusion, ATAXIC is a useful algorithm to quantify the TP heterogeneity in single cancer cells, as well as providing new insights into tumor biology.
Analysis of Average Temperature and Humidity On Smart Indoor Garden Design Arduino Uno Microcontroller Based

Salah satu inovasi dalam teknologi pertanian yang terus berkembang adalah konsep urban farming atau pertanian perkotaan. Konsep ini sangat sesuai untuk diimplementasikan saat ini mengingat semakin terbatasnya lahan untuk kegiatan bercocok tanam di perkotaan. Selain itu konsep ini juga memungkinkan kegiatan bercocok tanam dilakukan di dalam ruangan (indoor farming). Penelitian tentang sistem yang mendukung konsep ini terus dikembangkan sampai kepada penggunaan perangkat pintar berbasis mikrokontroler arduino uno, sehingga terciptalah sistem smart indoor garden. Penelitian tentang rancang bangun sistem smart indoor garden berbasis perangkat pintar dengan menggunakan mikrokontroler arduino melibatkan beberapa prosedur pengujian alat dan pengujian sensor, diantaranya sensor suhu dan sensor kelembaban. Dalam penelitian ini dilakukan analisis statistitika inferensi terhadap data hasil pengukuran suhu dan kelembaban udara pada sistem smart indoor garden. Pengukuran suhu dan kelembaban udara dilakukan dengan menggunakan termometer digital dan sensor DHT22 yang ditempatkan pada ruang smart indoor garden. Dari hasil analisis terhadap data suhu udara diperoleh bahwa tidak ada perbedaan rata-rata suhu udara yang diukur dengan menggunakan termometer digital dan sensor DHT22, dengan nilai-p adalah 0,174. Sedangkan dari hasil analisis data kelembaban udara diperoleh bahwa terdapat perbedaan rata-rata kelembaban udara yang diukur dengan menggunakan termometer digital dan sensor DHT22, dengan nilai-p adalah 0,001.
Accurate Cultivar Authentication of Jujube Fruits Using Nano-Fluidic Genotyping of Single Nucleotide Polymorphism (SNP) Markers

Chinese jujube (Ziziphus jujuba Mill.) is an economically important fruit tree that is highly adapted to marginal crop lands and can be grown under a very broad range of climate conditions. Jujube fruits produced from several traditional cultivars in Ningxia, China have enjoyed a premium market price due to their unique flavor and quality attributes. One problem with the high-end jujube market is the adulteration of premium cultivars. The accurate identification of the genetic identity of single jujube fruits is essential for cultivar traceability and authentication. The multi-locus SNP barcoding approach offers an effective solution for cultivar authentication of jujube fruits. To identify variant SNP sequences a nanofluidic array approach was used to test the efficacy of this method with DNA extracted from the fruit pulp of eight jujube cultivars from Ningxia, China. The SNP marker profiles identified the genetic identity of each fruit unambiguously based on multilocus matching and ordination analysis. Results for repeated sampling of multiple fruits from the same tree (using independent DNA extractions) showed a high level of concordance, which demonstrated the reliability of SNP based genotyping platform. This method can handle 100 s to 1000 s of samples per day (based on the platform used). It is robust and cost-effective and has a high potential for its practical application in the jujube industry. The developed method and protocol can be readily applied for botanical authentication of other stone fruits in general.
Examining the Influences of COVID-19 Information Avoidance and Uncertainty on Perceived Severity of the Pandemic: Applications from the Health Belief Model and Weick’s Model of Organizing

Public health responses to the COVID-19 pandemic have been insufficient at keeping the virus from spreading rapidly and threatening public health around the globe. Not only has society been challenged by biomedical issues of disease contagion, infection, morbidity, and mortality, but has also confronted complex cognitive challenges to making sense of this health threat, especially related to accurately evaluating and responding appropriately to the severity of the pandemic. Perceived severity is an important cognitive factor associated with public willingness to adopt needed prevention, protection, and treatment behaviors for responding to serious health risks, like COVID-19. Information avoidance and uncertainty are important constructs from powerful public health and communication theories, including the health belief model and Weick’s model of organizing, that guide this study by describing how information influences responses to health threats. We used survey data collected from 561 college students to clarify the relationships among information avoidance, beliefs about unpredictability, and the perceived severity of COVID-19. We found that higher information avoidance was associated with lower perceived severity, and that this association depended on people’s unpredictability beliefs. Specifically, for those who had low assessments about unpredictability, we observed a strong negative association between information avoidance and perceived severity. Among those who had high perceived unpredictability levels, we observed a weak negative association between information avoidance and perceived severity. This study evaluates influences of information avoidance and uncertainty on perceived severity of COVID-19. The findings can help guide strategies for enhancing public response to this pandemic and future health threats.
Risk Factors of Benign Stricture of Anastomotic Stoma after Esophagectomy and Therapeutic Effect of Stent Implantation

With the increase in the number of patients and prolongation of their lives after esophagectomy for esophageal cancer, the quality of life after surgery has attracted more and more attention. Although anastomotic stenosis is a common complication, it seriously affects the quality of life and psychological state of patients or even threatens their lives. At present, the exact independent influencing factors of anastomotic stenosis after esophageal cancer surgery have not been determined, and relevant treatment options are still controversial. Here, we analyzed the independent risk factors leading to good postoperative anastomotic stenosis, in order to provide a basis for late prevention. At the same time, we deeply discussed the advantages and safety of stent implantation in the treatment of anastomotic stenosis.
Lean Public Construction in the Project Definition Phase: The Case of Peru

Public construction in developing countries is characterized by a lack of quality design information, poor front-end engineering studies, fragmented procurement, and financial obstacles. As a result, projects exhibit major delays, cost overruns, and contract resolution during construction which end up in failed projects. These issues cause dramatic losses in value for end-users and society. Current literature suggests that the main issues in public construction are rooted in the strategic definition, briefing, and concept design. To tackle these problems, the current research will focus on understanding the value-generating principles of public construction at the project definition phase by using the Lean Project Delivery System (LPDS). The methodology in this research is inductive and based on qualitative data. The case of Peru was used as a case representing a developing country. The findings show that the value-generating principles for public construction are end-user consideration, asset functionality, transparency, efficiency, predictability, and efficacy. However, the institutional pressures both enable and constrain public managers’ ability to deliver the expected outcomes and value. This represents a great opportunity to deploy lean methods at the beginning of the project to improve transparency, collaboration, and drive innovation. Future studies can develop a lean-enabled framework for public construction and scrutinize the constraints for value generation. and the means to achieve better project outcomes. The findings show that the value-generating principles for public construction extend beyond the end-user perspective. Public projects are deployed within a complex institutional environment that requires the generation of value for the government and the public manager to reduce controversies, cost overruns, corruption, and ultimately resolution of contracts and failed projects that cause profound losses to society. The findings show that the value-generating principles for public construction are end-user consideration, asset functionality, transparency, efficiency, predictability, and efficacy. Furthermore, the LPDS can be extended to consider the specific case of public construction and include the value-generating principles encapsulated in the complex legalistic and managerial context, which led us to propose the alignment matrix that potentially closes the gap of the lack of consensus between project outcomes and value delivered. Further research can develop a framework for Lean Public Construction and scrutinize case studies with the use of Lean tools and methods at the earliest stage of public projects in developing countries to assess performance.
Comparing Student and Recruiter Evaluations of Computer Science Resumes

Contribution: This study identifies which entry-level computer science (CS) resume items are most important and compares the ratings of student and recruiter participants to investigate the accuracy of student beliefs. To the authors’ knowledge, this study is the first to analyze the extent to which CS students understand the resume screening process. The results of this have consequences for students in their own resume development. Background: Although prior research studies the importance of different resume items generally, little is known about resumes for CS majors, which may contain distinctive sections. Less still is known about whether students understand the resume screening process. Research Questions: Which items on entry-level CS resumes most directly influence screening decisions? What gaps exist between CS students’ and recruiters’ perceptions of resume items? Does the disparity in expertise between students and recruiters contribute to differences in resume screening? Methodology: 197 recruiters and 73 CS undergraduates screened randomized CS resumes. Data were analyzed using ordinary least-squares regression with interactions. Findings: Students were more likely than recruiters to move resumes to the next level and spent about 7 s less than recruiters when screening resumes. Though students correctly assessed the value of most resume items, they significantly overestimated the value of prior work experience such as internships.
Super DIOS for exploring dark baryon

The super DIOS mission is a candidate of Japanese future satellite program after 2030’s and this scientific concept has been approved to establish an ISAS/JAXA research group. The main aim of the super DIOS is a x-ray survey to quantify of baryons, over several scales, from the circumgalactic medium around galaxies, cluster outskirts to the warm-hot intergalactic medium along the large cosmic structure by detections of the redshifted emission lines from OVII, OVIII and other ions, for investigating the dynamical state of baryons, including energy flow and metal cycles, in the universe. The super DIOS will have a resolution of 15 arcseconds and 3 kilo-pixels of transition edge sensor (TES) and its micro-wave SQUID multiplexer read-out system. This performance resolves most contaminating x-ray sources and reduces the level of diffuse x-ray background after subtracting point-like sources. The technical achievements of on-board cooling system reached by the Hitomi (ASTRO-H) and XRISM for microcalorimeter provide baseline technology for Super DIOS. We will also have a large scale collaborations with multi wave-length survey projects such as optical and radio survey observations.
Deletion of the CD2v Gene from the Genome of ASFV-Kenya-IX-1033 Partially Reduces Virulence and Induces Protection in Pigs

Infection of pigs with the African swine fever virus (ASFV) leads to a devastating hemorrhagic disease with a high mortality of up to 100%. In this study, a CD2v gene deletion was introduced to a genotype IX virus from East Africa, ASFV-Kenya-IX-1033 (ASFV-Kenya-IX-1033-∆CD2v), to investigate whether this deletion led to reduced virulence in domestic pigs and to see if inoculation with this LA-ASFV could induce protective immunity against parental virus challenge. All pigs inoculated with ASFV-Kenya-IX-1033-ΔCD2v survived inoculation but presented with fever, reduced appetite and lethargy. ASFV genomic copies were detected in only one animal at one time point. Seven out of eight animals survived subsequent challenge with the pathogenic parental strain (87.5%) but had mild to moderate clinical symptoms and had a gross pathology compatible with chronic ASFV infection. All mock-immunised animals developed acute ASF upon challenge with ASFV-Kenya-IX-1033 and were euthanised upon meeting the humane endpoint criteria. ASFV genome copy numbers after challenge were similar in the two groups. ASFV-Kenya-IX-1033-∆CD2v is therefore a useful tool to investigate the development of immunity to ASFV genotype IX, but safety concerns preclude its use as a candidate vaccine without further attenuation.
5-level torque-hysteresis controller for DTC based IM drive

In the recent trade demand, the AC machines and drives are extensively utilized. Normally, the AC drives exploit with high efficacy as well as high performance. Among other things, one of the best control strategies is Direct torque control (DTC). For this article, the induction motor drive is projected very simple amended DTC scheme in accordance with the hysteresis controller. By the reason of its modest assembly & effective execution, DTC is used for AC as well as DC drive as associated to other monitoring structures. The presence of high ripple content in output torque for DTC scheme is only an obstacle. This article approaches extenuation of the ripples in torque by varying the predictable 5-level torque hysteresis controller used in DTC. The expansion of distinctive switching approach has been generated for chosen voltage vector. On the basis of ripple content simulation outcomes fulfilled in MATLAB/SIMULINK for hysteresis torque controller to minimized the ripples.
Dark Matter Particles

Researchers have been able to infer the existence of Dark Matter (DM) only from the gravitational effect it seems to have on visible matter. DM seems to outweigh visible matter roughly six to one, making up about 27% of the universe. Here's a sobering fact: The matter we know and that makes up all stars and galaxies only accounts for 5% of the content of universe! But what is DM? [1]. Many experiments to detect and study Dark Matter Particles (DMPs) directly are being actively undertaken, but none have yet succeeded. Indirect detection experiments search for the products of the self-annihilation or decay of DMPs in outer space [2]. In the present paper, we discuss the main ideas of the developed Hypersphere World-Universe Model (WUM), introduce additional new DMP “XION” (boson) that is an analog of Axion, and consider a distribution of particles in the World including DMPs (four fermions and three bosons) and Ordinary particles (protons, electrons, photons, and neutrinos).
A New Look at Changma

This study revisits the definition of Changma, which is the major rainy season in Korea and corresponds to a regional component of the East Asian summer monsoon system. In spite of several decades of researches on Changma, questions still remain on many aspects of Changma that include its proper definition, determination of its onset and retreat, and relevant large-scale dynamical and thermodynamical features. Therefore, this study clarifies the definition of Changma (which is a starting point for the study of interannual and interdecadal variability) using a basic concept of air mass and front by calculating equivalent potential temperature () that considers air temperature and humidity simultaneously. A negative peak in the meridional gradient of this quantity signifies the approximate location of Changma front. This front has previously been recognized as the boundary between the tropical North Pacific air mass and cold Okhotsk sea air mass. However, this study identifies three more important air masses affecting Changma: the tropical monsoon air mass related to the intertropical convergence zone over Southeast Asia and South China Sea, the tropical continental air mass over North China, and intermittently polar continental air mass. The variations of these five air masses lead to complicated evolution of Changma and modulate intensity, onset and withdrawal dates, and duration of Changma on the interannual time scale. Importantly, use of , 500-hPa geopotential height and 200 hPa zonal wind fields for determining Changma onset and withdrawal dates results in a significant increase (up to~57%) in the hindcast skill compared to a previous study.
Preparation of Calcium Stearate-Coated Kapok Fibers for Oil Sorption

Kapok fiber has been known for its hydrophobic-oleophilic characteristics and exhibits a great potential as oil sorbent. Methods in enhancing its hydrophobicity have been explored to improve its sorption performance in oil-in-water applications. This study investigates the oil sorption performance and hydrophobicity of kapok fibers coated with calcium stearate, a known waterproofing agent. The calcium stearate solution was prepared by mixing known amounts of stearic acid and calcium chloride in an ethanol solution. This was followed by hydrolysis using 0.12 M sodium hydroxide solution. The calcium stearate-coated kapok fibers exhibited higher hydrophobicity compared to raw kapok fibers with a water contact angle of ~137°. It achieved the highest oil sorption capacity and reusability of 50 g/g and 65% for viscous motor oil, respectively.
Revisiting the Carrington Event: Updated modeling of atmospheric effects

The terrestrial effects of major solar events such as the Carrington white-light flare and subsequent geomagnetic storm of August-September 1859 are of considerable interest, especially in light of recent predictions that such extreme events will be more likely over the coming decades. Here we present results of modeling the atmospheric effects, especially production of odd nitrogen compounds and subsequent depletion of ozone, by solar protons associated with the Carrington event. This study combines approaches from two previous studies of the atmospheric effect of this event. We investigate changes in NOy compounds as well as depletion of O3 using a two-dimensional atmospheric chemistry and dynamics model. Atmospheric ionization is computed using a range-energy relation with four different proxy proton spectra associated with more recent well-known solar proton events. We find that changes in atmospheric constituents are in reasonable agreement with previous studies, but effects of the four proxy spectra used vary more widely than found by one of those studies. In particular, we find greater impact for harder proton spectra, given a constant total fluence. We report computed nitrate deposition values and compare to measured values in ice cores. Finally, we briefly investigate the impact of the modeled ozone depletion on surface-level solar ultraviolet radiation.
Recognition, Measurement, Presentation and Disclosure of Corporate Social Responsibility (CSR) Costs PT. Kawasan Industri Makassar (Persero)

The study aims to determine and analyze the application of corporate social responsibility accounting at PT Kawasan Industri Makassar (Persero). This research is qualitative with a descriptive analysis approach. The results of the study indicate accounting practices (recognition, measurement, presentation, and disclosure) of the costs of corporate social responsibility by PT Kawasan Industri Makassar (Persero) are under the Basic Framework for the Preparation and Presentation of Financial Statements (KDPPLK). PT Kawasan Industri Makassar (Persero) already has a specific financial report that refers to SAK ETAP, which is oriented to the non-profit sector by establishing a Small Business and Cooperative Development Unit, which is now called the Partnership and Community Development Program Unit (PKBL) which has been edited by Public accounting firm. There are no normative rules related to the cost accounting for CSR and the importance of environmental and social factors, so the findings of this study have practical implications for other business actors who should have their own business units that focus on social and environmental aspects.
Evaluation of glycolaldehyde as a formaldehyde substitute in urea-based wood adhesives

Glycolaldehyde, produced from cracking of glucose, was tested as a substitute for formaldehyde in urea-based wood adhesives. Initially, different parameters (water content, aldehyde/urea-ratio, curing temperature, and time) were screened to identify the optimal curing conditions providing the highest bond strength. Afterwards, the system was reformulated as a 2-component system and compared to a urea-formaldehyde 2-component system, which showed a comparatively low strength of the resulting resin. Different hardeners were tested, and AlCl3 showed an 80% increase in bond strength for the resin compared to NH4Cl. Infrared and nuclear magnetic resonance analyses were performed to ensure formation of the desired aminal bond network, which showed that the hardener was essential for proper curing of the resin. Finally, a urea-glycolaldehyde-formaldehyde resin was tested that further indicated major differences between the reactivity of formaldehyde and glycolaldehyde.
A maximum entropy method for convex programming

Maximum entropy methods which have been developed in recent years are very effective for solving nonlinear programming. In the maximum entropy method a differentiable uniformly approximate function for the maximum function is constructed so that a multi-constrained nonlinear programming can be approximated by the one with a single constraint and an approximate solution can be obtained by solving the latter programming. In this note, the important properties of the maximum entropy method for