Miracle-dz/UniFAR-FTUs huggingface dataset:
French registry of cases of type I acute aortic dissection admitted to a cardiac rehabilitation center after surgery

Background After surgery for type I acute aortic dissection, the aorta remains partly dissected. This new population of patients is now referred to cardiac rehabilitation centers (CRCs). The feasibility of subsequent physical exercise is unknown. Methods Thirty-three consecutive patients (aged 55.1 ± 9.3 years) were included in a prospective registry with clinical and radiological follow-up for 1 year after admission to a CRC. Twenty-six patients had undergone standard training sessions with exercise on a bicycle ergometer. Physical training programs included calisthenics, respiratory physiotherapy, walking, and cycling. Seven patients did not perform standard exercise training sessions but only walking and respiratory physiotherapy. Results For trained patients, the sessions (18 ± 10) were carried out at 11.3 ± 1.5 on the Borg scale (‘light’), with blood pressure monitoring on exercise (<160 mmHg in 75% of patients). Maximum workload during exercise test (bicycle ergometer, 10 watts/min) increased from 62.7 ± 11.8 to 91.6 ± 16.5 watts (P = 0.002). We identified three complications in two patients requiring further thoracic aorta surgery during follow-up. There was also one case of aortic valve replacement after 5 months and three cases of peripheral ischemia. No deaths, cerebral vascular accidents, or myocardial infarctions were recorded. Ten of the 19 patients of working age were able to return to work. Conclusion Physical training of moderate intensity seems feasible and beneficial in postsurgical type I aortic dissection patients. Eur J Cardiovasc Prev Rehabil 16:91-95 © 2009 The European Society of Cardiology
The Origin of Fe II Emission in AGN

We used a very large set of models of broad emission line (BEL) clouds in AGN to investigate the formation of the observed Fe II emission lines. We show that photoionized BEL clouds cannot produce both the observed shape and observed equivalent width of the 2200-2800A Fe II UV bump unless there is considerable velocity structure corresponding to a microturbulent velocity parameter v_turb > 100 km/s for the LOC models used here. This could be either microturbulence in gas that is confined by some phenomenon such as MHD waves, or a velocity shear such as in the various models of winds flowing off the surfaces of accretion disks. The alternative way that we can find to simultaneously match both the observed shape and equivalent width of the Fe II UV bump is for the Fe II emission to be the result of collisional excitation in a warm, dense gas. Such gas would emit very few lines other than Fe II. However, since the collisionally excited gas would constitute yet another component in an already complicated picture of the BELR, we prefer the model involving turbulence. In either model, the strength of Fe II emission relative to the emission lines of other ions such as Mg II depends as much on other parameters (either v_turb or the surface area of the collisionally excited gas) as it does on the iron abundance. Therefore, the measurement of the iron abundance from the FeII emission in quasars becomes a more difficult problem.
Cost-Effectiveness of Fluvastatin following Successful First Percutaneous Coronary Intervention

BACKGROUND: In the LIPS (Lescol Intervention Prevention Study), fluvastatin 80 mg/day reduced the risk of major adverse cardiac events (MACE) by 22% versus placebo (p = 0.01) following successful first percutaneous coronary intervention (PCI) in patients with stable or unstable angina or silent ischemia. The cost-effectiveness of such therapy is unknown. OBJECTIVE: To evaluate the cost-effectiveness of fluvastatin following successful first PCI from a US healthcare system perspective. METHODS: We used a Markov model to estimate expected outcomes and costs of 2 alternative treatment strategies following successful first PCI in patients with stable or unstable angina or silent ischemia: (1) diet/lifestyle counseling plus immediate fluvastatin 80 mg/day; and (2) diet/lifestyle counseling only, with initiation of fluvastatin 80 mg/day following occurrence of future nonfatal MACE. The model was estimated with data from LIPS and other published sources. Cost-effectiveness was calculated as the ratio of the difference in expected medical-care costs to the expected difference in life-years (LYs) and quality-adjusted life-years (QALYs) alternatively. RESULTS: Treatment with fluvastatin following successful first PCI was found to increase life expectancy by 0.78 years (QALYs 0.68). Cost-effectiveness of fluvastatin following successful first PCI is $13 505 per LY ($15 454 per QALY) saved. Ratios are lower for patients with diabetes ($9396 per LY; $10 718 per QALY) and those with multivessel disease ($9662 per LY; $11 076 per QALY). Findings were robust with respect to changes in key model parameters and assumptions. CONCLUSIONS: Fluvastatin therapy following PCI is cost-effective compared with other generally accepted medical interventions.
Goal Management Training improves everyday executive functioning for persons with spina bifida: Self-and informant reports six months post-training

Executive dysfunction accounts for significant disability for many patients with spina bifida (SB), thus indicating the need for effective interventions aimed at improving executive functioning in this population. Goal Management Training™ (GMT) is a cognitive rehabilitation approach that targets disorganised behaviour resulting from executive dysfunction, and has received empirical support in studies of other patient groups. The purpose of this study was to determine if GMT would lead to perceived improved executive functioning in the daily lives of patients with SB, as evidenced by reduced report of dysexecutive problems in daily life on self- and informant questionnaires. Thirty-eight adults with SB were included in this randomised controlled trial (RCT). Inclusion was based upon the presence of executive functioning complaints. Experimental subjects (n = 24) received 21 hours of GMT, with efficacy of GMT being compared to results of subjects in a wait-list condition (n = 14). All subjects were assessed at baseline, post-intervention, and at six-month follow-up. Self-report measures indicated that the GMT group's everyday executive functioning improved significantly after training, lasting at least 6 months post-treatment. There were no significant effects on informant-report questionnaires. Overall, these findings indicate that executive difficulties in everyday life can be ameliorated for individuals with congenital brain dysfunction.
Radiochemotherapy-induced changes of tumour vascularity and blood supply estimated by dynamic contrast-enhanced CT and fractal analysis in malignant head and neck tumours

Objective: To investigate radiochemotherapy (RChT)-induced changes of transfer coefficient ( K trans ) and relative tumour blood volume (rTBV) estimated by dynamic contrast-enhanced CT (DCE-CT) and fractal analysis in head and neck tumours (HNTs). Methods: DCE-CT was performed in 15 patients with inoperable HNTs before RChT, and after 2 and 5 weeks. The dynamics of K trans and rTBV as well as lacunarity, slope of log(lacunarity) vs log(box size), and fractal dimension were compared with tumour behaviour during RChT and in the 24-month follow-up. Results: In 11
Two-way quality assessment approach for tumour detection using free-hand strain imaging

A novel two-way image quality assessment method is proposed for free-hand strain imaging. In elasticity imaging, tissue with different stiffness exhibit varying contrast in the strain images and detectability of a lesion is measured using elastographic contrast-to-noise ratio (CNRe). Representing quality of strain images quantitatively is vital for improving imaging techniques and also for clinical diagnosis. It avoids the subjective approach of interpreting strain images. Conventionally, contrast between stiff lesion and surrounding soft tissue is measured using contrast-to-noise ratio and strain image with the highest CNRe amplitude is considered an optimal strain image. However experimental results have suggested that merely CNRe metric is often misleading and does not always represent the true elastic modulus contrast as the correlation coefficient falls below an acceptable levels and accuracy is compromised. Therefore in this study, the objective is to propose a comprehensive strain image quality assessment method which is reliable for clinical examinations and research.
Cell attachment, collagen binding, and receptor analysis on bovine articular chondrocytes

The purpose of this study was to investigate collagen receptors on primary bovine articular chondrocytes from full‐thickness and different layers of bovine articular cartilage. Cytometric studies with antibodies showed that approximately 56% of the chondrocytes from the superficial layer and 29% of the chondrocytes from the deep layer bound anti‐annexin V. A similar tendency was found for α and β1 integrin antibodies. Flow cytometric analysis initially detected annexin V on chondrocytes following isolation; the level of detection subsequently decreased by 24 hours, whereas that of α5 and β1 integrins increased. Treatment of chondrocytes with collagenase at 24 hours restored the initially high epitope recognition of annexin V, indicating masking of annexin V by newly formed collagen matrix. There was little effect on detection levels for β1 integrin. Contrary to the specific matrix receptor expression, chondrocytes from superficial and deep layers differed little in attachment to immobilized types I and II collagens. However, the attachment was more effectively inhibited with anti‐annexin V than with integrin antibodies. Competition studies with preparations of soluble collagens revealed a preferential binding of bovine type‐II collagen compared with bovine type‐I collagen. Anti‐annexin V antibodies inhibited binding of type‐II collagen more effectively than anti‐α5 or anti‐β1 integrin antibodies. Evidently, under the in vitro conditions of this study, annexin V is the quantitatively predominant type‐II collagen receptor on bovine articular chondrocytes. This opens a discussion of the possibly dualistic metabolic/mechanical annexin V‐integrin receptor elements.
Mental Cloning Base Virtual Diagnostician System - Virtual Medical Doctor System (VDS) Reasoning

Human computer Interaction based on emotional modelling and physical views, collectively; has been investigated and reported in this paper. Two types of ontology have been presented to formalize a patient state: mental ontology reflecting the patient mental behaviour due to certain disorder and physical ontology reflecting the observed consequences of such disorder. These two types of ontology have been mapped and aligned for reasoning purposes. We have constructed an integrated computerized model which reflects a human diagnostician as computer model and through it, an integrated interaction between that model and the real human user (patient) is utilized for 1 stage diagnosis purposes. The diagnostician knowledge has been utilized through UMLS for testing, and the integrated mapping of the two views been represented through OWL framework. The reasoning instantiation is done using Description logic. We have implemented the system and empirically, examining it, for revision and evaluation.
Discussion Papers Have State Renewable Portfolio Standards Really Worked ? Synthesizing Past Policy Assessments to Build an Integrated Econometric Analysis of RPS Eff ectiveness in the

Renewable portfolio standards (RPS) are the most popular U.S. state-level policies for promoting deployment of renewable electricity (RES-E). While several econometric studies have estimated the effect of RPS on in-state RES-E deployment, results are contradictory. We reconcile these studies and move toward a definitive answer to the question of RPS effectiveness. We conduct an analysis using time series cross sectional regressions – including the most nuanced controls for policy design features to date – and nonparametric matching analysis. We find that higher RPS stringency does not necessarily drive more RES-E deployment. We examine several RPS design features and market characteristics (including REC unbundling, RPS in neighboring states, out-of-state renewable energy purchases) that may explain the gap between effective and ineffective policies. We also investigate other RES-E policies and technology-specific effects. Ultimately, we show that RPS effectiveness is largely explained by a combination of policy design, market context, and inter-state trading effects.
Analysis of Bandwagon and Average Hybrid Attack Model against Trust-based Recommender Systems

Recommender systems have been accepted as a vital application on the web by offering product advice or information that users might be interested in. Despite its success, similarity-based collaborative filtering suffers from some significant limitations, such as scalability, sparsity and recommendation attack. Prior work has shown incorporating trust mechanism into traditional collaborative filtering recommender systems can improve these limitations. However, trust-based recommender systems are also known to be vulnerable to profile infection attacks. Malicious users can inject a large number of biased profiles into such a system in order to make recommendations that favor or disfavor given items. In this paper, we propose a bandwagon and average hybrid attack model and analysis the effectiveness of the attack model against topic-level trust-based recommender algorithm. The results of our experiments conducted on well-known dataset show that the hybrid attack model is more effective than other attack models.
Systems Analysis and Integrated Assessment 1-1 June 2015 , Gold Coast , Australia Plant-wide Modelling of N and P Removal with Aerobic and Anoxic-Aerobic Digestion of Waste Sludge

When waste activated sludge (WAS) from biological nutrient removal (BNR) activated sludge (AS) systems is thickened to 3-6% TSS and then digested (aerobic or anaerobic), a high proportion of Nitrogen (N) and phosphorus (P) is released to the bulk liquid resulting in high concentrations of ammonia and orthophosphate up to several hundred mg/l (without denitrification or P precipitation) (Vogts et al., 2014). To avoid the complexity of N removal from digested sludge dewatering liquor, Vogts et al. (2014) investigates N removal by nitrification and denitrification and P removal by P precipitation in anoxic-aerobic digestion (AAD) of P rich BNR system WAS. The plant-wide experimental set up for this investigation (i.e., a UCT process BNR system connected to continuous anoxic-aerobic digesters) was simulated, using the three phase (aqueous-gas-solid) plant wide model of Ikumi et al. (2014), as part of the model evaluation process. In the AAD, the P accumulating organisms (PAOs) do not grow but undergo endogenous respiration, releasing their stored polyphosphate (PP) as magnesium (Mg), calcium (Ca), potassium (K) and orthophosphate (OP). This PP release, with endogenous respiration in the AAD, occurs gradually with PAO death, and not rapidly as observed in AD systems (Harding et al., 2009; Ikumi, 2011). This released PP results in high concentrations of P and cations in the aqueous phase of the mixed liquor, resulting in formation of struvite (MgNH4PO4). Initially, it was expected that K-struvite (MgKPO4) would form, due to projected nitrification (hence low NH4) AAD systems. However, K-struvite did not precipitate due to its low solubility product, and it being known to precipitate at high pHs (about 10, Wilsenach et al. 2007; Taylor et al. 1963).
Dependency in the Treatment of Complex Posttraumatic Stress Disorder and Dissociative Disorders

Abstract Dependency is a major and ubiquitous issue in the treatment of chronically traumatized patients, such as those with complex posttraumatic stress disorder (PTSD), trauma-related borderline personality disorder, and dissociative disorders. Within this context, the concept of dependency is often paired with pejorative adjectives, and is dichotomized and negatively compared to a preferred state of independence. This paper explores prevailing sociocultural and theoretical beliefs regarding dependency in the psychotherapy of trauma survivors, provides a working definition of dependency, offers an analysis of its complex nature, and describes the theory of structural dissociation, which helps illuminate the often contradictory manifestations of dependency in chronically traumatized patients. A distinction is made between secure and insecure dependency. Finally, this paper outlines the collaborative therapeutic process required to manage insecure dependency productively within a phase-oriented treatment model. Countertransference responses that interfere with a patient's conflicts regarding dependency are also discussed.
Cardiovascular Mitochondria and Redox Control in Health and Disease Rotenone-stimulated superoxide release from mitochondrial complex I acutely augments L-type Ca 2 current in A 7 r 5 aortic smooth muscle cells

Ochi R, Dhagia V, Lakhkar A, Patel D, Wolin MS, Gupte SA. Rotenone-stimulated superoxide release from mitochondrial complex I acutely augments L-type Ca current in A7r5 aortic smooth muscle cells. Am J Physiol Heart Circ Physiol 310: H1118–H1128, 2016. First published February 12, 2016; doi:10.1152/ajpheart.00889. 2015. —Voltage-gated L-type Ca current (ICa,L) induces contraction of arterial smooth muscle cells (ASMCs), and ICa,L is increased by H2O2 in ASMCs. Superoxide released from the mitochondrial respiratory chain (MRC) is dismutated to H2O2. We studied whether superoxide per se acutely modulates ICa,L in ASMCs using cultured A7r5 cells derived from rat aorta. Rotenone is a toxin that inhibits complex I of the MRC and increases mitochondrial superoxide release. The superoxide content of mitochondria was estimated using mitochondrial-specific MitoSOX and HPLC methods, and was shown to be increased by a brief exposure to 10 M rotenone. ICa,L was recorded with 5 mM BAPTA in the pipette solution. Rotenone administration (10 nM to 10 M) resulted in a greater ICa,L increase in a dose-dependent manner to a maximum of 22.1% at 10 M for 1 min, which gradually decreased to 9% after 5 min. The rotenone-induced ICa,L increase was associated with a shift in the current-voltage relationship (I-V) to a hyperpolarizing direction. DTT administration resulted in a 17.9% increase in ICa,L without a negative shift in I–V, and rotenone produced an additional increase with a shift. H2O2 (0.3 mM) inhibited ICa,L by 13%, and additional rotenone induced an increase with a negative shift. Sustained treatment with Tempol (4-hydroxy tempo) led to a significant ICa,L increase but it inhibited the rotenone-induced increase. Staurosporine, a broad-spectrum protein kinase inhibitor, partially inhibited ICa,L and completely suppressed the rotenone-induced increase. Superoxide released from mitochondria affected protein kinases and resulted in stronger ICa,L preceding its dismutation to H2O2. The removal of nitric oxide is a likely mechanism for the increase in ICa,L.
Additional Restriction Endonuclease Cleavage Sites on the Bacteriophage P22 Genome

We present complete restriction endonuclease cleavage site maps of the bacteriophage P22 chromosome for 16 enzymes with six base recognition sequences, thereby positioning 116 new sites on the chromosome. Twenty-four such restriction maps for P22 DNA, containing 162 sites, have now been completed, and three enzymes were found that did not cut P22 DNA. Our results are consistent with the ideas that ClaI does not cleave the methylated recognition sequence ATCGAmeT or AmeTCGAT and StuI does not cleave the methylated recognition sequence AGGCCmeT.
A comparison of SVM and asymmetric SIMPLS in emotion recognition from naturalistic dialogues

In this paper, we compare the performance of support vector machine (SVM) and asymmetric SIMPLS classifiers in emotion recognition from naturalistic dialogues. These two classifiers are evaluated on the SEMAINE corpus that involves emotional binary classification tasks of four dimensions, namely, activation, expectation, power, and valence. The experimental results reveal that the asymmetric SIMPLS (ASIMPLS) classifier is less sensitive to class distribution, faster training processing, and higher classification accuracy on the average unweight recall for develop sets than the baseline. Using the develop set, we provide analysis and simulation-based insights about the selection of the number of components for model validation of the ASIMPLS classifier. For the test sets, the performance of the ASIMPLS classifier achieves an absolute improvement of 6.10%, 6.14%, 24.45%, 1.32% on the weighted recall value on above-mentioned four dimensions, respectively, over the baseline model.
Divergent regulation of the human atrial natriuretic peptide gene by c-jun and c-fos

Employing transient transfection analysis in neonatal rat cardiocytes, we have demonstrated that overexpression of c-jun results in a dose-dependent induction of the human atrial natriuretic peptide (hANP) gene promoter. Studies using a series of mutations in the hANP gene promoter identified a TRE-like, cis-acting regulatory sequence which conferred c-jun sensitivity. This same region was shown to interact with the c-jun/c-fos complex in an in vitro gel mobility shift assay. Selective mutation of this site suppressed basal activity of the hANP promoter and significantly reduced c-jun-dependent activation. Overexpression of c-fos had a biphasic effect on hANP gene promoter activity. At low levels, in concert with c-jun, it activated, while at higher levels it suppressed, transcription from the hANP gene promoter. This inhibition was both cell and promoter specific. hANP gene promoter sequences which mediate c-fos-dependent inhibition appear to be separable from those responsible for the induction. In addition, the protein domains on c-fos responsible for transcriptional activation and repression can be segregated topographically, with the inhibitory activity being localized to the carboxy-terminal domain. Thus, c-fos can activate or repress hANP gene expression through two separate functional domains that act on distinct regulatory elements in the hANP gene promoter. These data imply that the ANP gene may be a physiological target for c-fos- and c-jun-dependent activity in the heart and suggest a potential mechanism linking environmental stimuli to its expression.
Tectonic Geomorphology of Alluvial Fans east of the Wadi Araba Fault (Dead Sea Transform), Jordan

This study deals with the development of alluvial fans at the foot of the fault-controlled eastern mountainous chain in Wadi Araba Desert (WAD). The alluvial fans are fed mainly by debris flows of ephemeral streams flowing westward across the eastern highlands to the desert plain and/or inland sabkhas. Morphometric analyses showed that fan surface area (FSA) is directly proportional to drainage basin area (DBA), whereas the fan slope (FS) is inversely proportional to 'FSA' or decreases proportionally as the talus cones evolve into fans. The architecture and evolution of the fan/drainage network are controlled by vigorous tectonic forces that began in the Early Miocene. Bedrock geology, history and rates of sediment supply, and the intensity and duration of surface flow more likely contributed to the progressive changes of fans/drainage basin system. The increment of 'FS' towards fan head pertinent to sediment buildup and the occurrence of steep normal fault scarps at mountain edges may reflect recent uplift in the catchment area. The alluvial fans were dislocated apart from drainage basins as a result of strike-slip movement along the Dead Sea transform (DST) and its subsidiary faults. Fanglomerates are compositionally immature and matrix-supported. The angular-subangular shape of clasts indicates a minimum or non-intensive abrasion has been occurred before sedimentation.