Miracle-dz/UniFAR-FTUs huggingface dataset:
Hepatosplenic γδ T-cell lymphoma presenting with Coombs’-negative hemolytic anemia: a case report

Hepatosplenic T-cell lymphoma (HSTCL) is a rare, highly aggressive T-cell lymphoma which is characterized by cytotoxic T cell proliferation in the sinusoids of liver, red pulp of the spleen, and sinuses of the bone marrow. HSTCL patients are mainly young men, commonly present with B-symptoms, hepatosplenomegaly and cytopenia, but hemolytic anemia is rare. Here we present a case of hepatosplenic γδ T cell lymphoma in a 32-year-old man who was presented with Coombs’-negative hemolytic anemia. 18FDG PET/CT demonstrated diffusely increased bone marrow uptake and hepatosplenomegaly with increased FDG uptake. Bone marrow morphological examination showed diffuse proliferation of CD7+CD3+CD16+TCRγδ+, CD5-CD4-CD8neoplastic T cells, detected by flow cytometry. Tumor lymphocytes also histologically seep into the sinus or sinus of the bone marrow and spleen. The patient underwent a variety of strong chemotherapy, but the condition quickly deteriorated and he eventually died of cerebral hemorrhage. The patient’s diagnosis and treatment procedure are described here, including a literature review.
Back-propagating rupture evolution within a curved slab during the 2019 Peru intraslab earthquake

The 26 May 2019 MW 8.0 Peru intraslab earthquake ruptured the subducting Nazca plate at a point 10 where the dip angle of the slab increases sharply and the strike angle rotates clockwise from the 11 epicenter to north. To obtain a detailed seismic source model of the 2019 Peru earthquake, including 12 not only the rupture evolution but also the spatiotemporal distribution of focal mechanisms, we 13 performed comprehensive seismic waveform analyses using both a newly developed flexible finite14 fault teleseismic waveform inversion method and a back-projection method. The source model 15 revealed a complex rupture process involving a back-propagating rupture. The initial rupture 16 propagated downdip from the hypocenter, then unilaterally northward along the strike of the slab. 17 Following a large slip occurring 50–100 km north of the hypocenter, the rupture propagated 18 bilaterally both further northward and back southward. The spatial distribution of focal mechanisms 19 shows that the direction of T-axis azimuth gradually rotated clockwise from the epicenter northward, 20 corresponding to the clockwise rotation of the strike of the subducting Nazca plate, and the large21 slip area corresponds to the high-curvature area of the slab iso-depth lines. Our results show that the 22 complex rupture process, including the focal-mechanism transition, of the Peru earthquake was 23 related to the slab geometry of the subducting Nazca plate. 24
CMAR_A_261838 8425..8433

1Department of Radiology, University Hospital Regensburg, Regensburg, Germany; 2Department of Radiology, Municipal Hospital Landshut, Landshut, Germany; 3Department of Radiology and Nuclear Medicine, Hospital Braunschweig, Braunschweig, Germany; 4Department of Diagnostic and Interventional Radiology, Ernst von Bergmann Hospital, Potsdam, Germany Purpose: To assess the incidence and evolution of biliary alterations adjacent to the ablation area in patients with hepatic malignancies during the first 3 months after percutaneous irreversible electroporation (IRE) and to investigate associated changes in laboratory values. Material and Methods: Bile ducts located within a ≤1.0 cm radius of the ablation zone were analyzed in 45 patients by preinterventional and postinterventional MRI (1–3 days, 6 weeks, and 3 months after IRE). Moreover, levels of alkaline phosphatase (AP) and serum bilirubin (SB) were examined for evidence of bile duct injury. Biliary alterations and the presence of postinterventional-elevated laboratory levels were correlated with features of the lesions, patients, ablation procedures, and laboratory values. Results: A total of 80 bile ducts were located within a 1.0 cm radius of the ablation zone: 59 were encased, 16 were abutting and 5 were located within a radius of 0.1–1.0 cm of the ablation area. In total, 38 biliary injuries (narrowing, n=22; dilatation, n=14; biloma, n=2) were detected, 3 cases of narrowing occurred for the first time 6 weeks and 3 months after IRE, 21 alterations (dilatation: n=9; narrowing; n=10; biloma: n=2) had resolved during the first 6 weeks, 1 alteration (dilatation: n=1) had resolved by the last follow-up control. Three months after IRE, 19 patients showed elevated levels of AP, whereas SB levels were increased in 10 cases. No significant association between biliary alterations or postinterventional-elevated laboratory values and the investigated characteristics of lesions, patients, ablation procedures or laboratory values could be proven. Conclusion: Different alterations of bile ducts adjacent to an IRE ablation zone are common, of which dilatation and especially narrowing commonly represent a long-term complication after IRE. Moreover, a definite correlation between the frequently observed prolonged post-ablative elevation of APand SB-levels and the postinterventional biliary alterations could not be proven.
DMD066308 137..150

ThehumanpregnaneX receptor (hPXR) is a xenobiotic-sensing nuclear receptor that transcriptionally regulates drug metabolism–related genes. The aim of the present study was to elucidate the mechanism by which hPXR is regulated through threonine-408. A phosphomimetic mutationat threonine-408 (T408D) reduced the transcriptional activity of hPXR and its protein stability in HepG2 and SW480 cells in vitro and mouse livers in vivo. Proteasome inhibitors (calpain inhibitor I and MG132) and Hsp90 inhibitor geldanamycin, but not Hsp70 inhibitor pifithrin-m, increased wild-type (WT) hPXR in the nucleus. The translocation of the T408D mutant to the nucleus was significantly reduced even in the presence of proteasome inhibitors, whereas the complex of yellow fluorescent protein (YFP)-hPXR T408D mutant with heat shock cognate protein 70/heat shock protein 70 and carboxy terminusHsp70interacting protein (CHIP; E3 ligase) was similar to that of the WT in the cytoplasm. Treatment with pifithrin-m and transfection with anti-CHIP small-interfering RNA reduced the levels of CYP3A4 mRNA induced by rifampicin, suggesting the contribution of Hsp70 and CHIP to the transactivation of hPXR. Autophagy inhibitor 3-methyladenine accumulated YFP-hPXR T408D mutant more efficiently than the WT in the presence of proteasome inhibitor lactacystin, and the T408D mutant colocalized with the autophagy markers, microtubule-associated protein 1 light chain 3 and p62, which were contained in the autophagic cargo. Lysosomal inhibitor chloroquine caused the marked accumulation of the T408D mutant in the cytoplasm. Protein kinase C (PKC) directly phosphorylated the threonine-408 of hPXR. These results suggest that hPXR is regulated through its phosphorylation at threonine-408 by PKC, CHIP/chaperone–dependent stability check, and autophagic degradation pathway.
Indigenous Communities Versus Oil Companies: Identifying Trends in Tactics and Success of Indigenous-Led Anti-Petroleum Movements in the Ecuadorian Amazon

In roughly the last 50 years, the Ecuadorian Amazon has become the epicenter of petroleum production in Ecuador. As oil companies attempt to exploit more and more of the rainforest, they have encroached on indigenous lands, leading to violations of indigenous rights through environmental destruction. As their territories have been invaded, indigenous groups throughout the Amazon have formed movements large and small in resistance to petroleum activities. Scholars have studied select campaigns in the past, but the literature lacks a comparative review of the characteristics of those movements. This paper compiles histories of seven campaigns against petroleum in the Ecuadorian Amazon and compares them, focusing on analyzing the tactics groups used and the level of success they found. Results are inconclusive but uncover anecdotal similarities between Ecuadorian movements and those in other countries and open possibilities for future, more definitive research in this field.
Graph Convolutional Networks (GCNs) for Molecular Property Prediction in Drug Development

Molecular property prediction is key to drug development. The rising of deep learning techniques provides new possibilities to learn the molecular properties directly from chemical data. In particular, graph convolutional networks have been introduced into the field and made significant enhancements compared to traditional methods. The first part of this paper serves as a study to explore and evaluate this emerging method while the second part demonstrates that graph convolution networks can be further improved by incorporating attention mechanism, another influential deep learning idea.
Theoretical analysis of space-homogeneous plasma heating by explosive emission current

Emission properties of the explosive-emission cathode depend primarily on parameters of the cathode plasma. The state of the plasma is determined both by the conditions of its formation-processes at the cathode surface, and by the heating of plasma with emission current. Such a heating affects the plasma ionization state and, consequently, its emission ability which might, in turn, change current flow conditions in the diode. In the present work, the problem of heating of spatially homogeneous plasma by the emission current was treated taking into account ionization and recombination processes, with the purpose of elucidating conditions under which the cathode plasma parameters are significantly affected by the emission current.
Pharmacological characterization and molecular determinants of the activation of TRPV2 channel orthologs by 2-aminoethoxydiphenyl borate

Despite its expression in different cell types, TRPV2 is still the most cryptic members of the TRPV channel family. Recently, 2-aminoethoxydiphenyl borate (2APB) has been shown to be a common activator of TRPV1, TRPV2 and TRPV3, but 2APB-triggered TRPV2 activation remains to be thoroughly characterized. In this study we have developed an assay based on cell lines stably expressing mouse TRPV2 channels and intracellular calcium measurements to perform a pharmacological profiling of the channel. Phenyl borate derivatives were found to activate mouse TRPV2 with similar potencies, and thus were used to screen a panel of channel blockers. Beside the classical TRP inhibitors ruthenium red (RR) and SKF96365, two potassium channel blockers, tetraethylammonium (TEA) and 4-aminopyridine (4-AP), as well as an inhibitor of capacitative calcium entry, 1-(2-(trifluoromethyl)phenyl) imidazole (TRIM), were found to inhibit TRPV2 activation by 100 µ M 2APB. Activation by 300 µ M 2APB, however, could only be inhibited by RR and TRIM. Electrophysiological recordings demonstrated that TEA inhibition was use-dependent suggesting that high concentrations of 2APB might induce a progressive conformational change of the channel. Comparison of TRPV2 orthologs revealed that the human channel was insensitive to 2APB. Analysis of chimeric constructs of mouse and human TRPV2 channels showed that the molecular determinants of 2APB sensitivity could be localized to the intracellular amino- and carboxy- domains. Finally, using lentiviral-driven expression we demonstrate that hTRPV2 exerts a dominant-negative effect on 2APB activation of native rodent TRPV2 channels and thus may provide an interesting tool to investigate cellular functions of TRPV2 channels. by 2APB. We show that 2APB activates mouse and rat TRPV2 orthologs with different potencies, whereas the human TRPV2 channel is remarkably insensitive to 2APB. Through chimeric
Professional Competencies versus High Performance Work Systems in Brazil, Russia, India and Taiwan

This paper aims to investigate the relations between professional competencies and high performance work systems, analyzing to what extent the demand for contemporary professional competencies has been followed by changes in the high performance work systems in organizations operating in emerging economies. Regarding the research method, a survey was conducted with a sample of 1,035 professionals enrolled in graduate management programs from four economies (Brazil, Taiwan, Russia and India). The results indicate a relationship between professional competencies and high performance work systems (administrative and people management dimension, political dimension, cultural dimension. In addiction, the results indicate differences among Brazil, Russia, India and Taiwan as concerns professional competencies required by organizations and in relation to the high performance work systems adopted by organizations (in the administrative and people management dimension, the political dimension and the cultural dimension).
TSZ WAH MA EVERYDAY LIFE EMOTIONS DURING ANTI-FUGITIVE OFFENDERS ORDINANCE PROTESTS

This experience sampling study investigated the impact of political movement (i.e. Anti-Fugitive Offenders Ordinance Protests) on everyday emotional reactivity and dynamics. Participants who finished our experience sampling during Movement (18–70 years; n = 100) and matched sample (18–70 years; n = 100) reported positive and negative emotions seven times a week for five weeks. Hierarchical linear modeling revealed that during the Movement, participants reported lower positive emotions and higher negative emotions, and lower positive emotional inertia and higher nega tive emotional inertia. This study is the first of its kind to investigate different aspects of everyday emotional experiences during political movements. Participants perceived significant changes in their everyday events although the Movement was not long and not severely violent. This study highlights the importance of investigating everyday emotions of people in other more serious conflict and post-conflict settings.
Predicting DDoS Anomaly Patterns in SDN Controller using Hidden Markov Model

The introduction of Software Defined Networking (SDN) as a panacea to the global demand for a more secure and highly dependable internet infrastructure has also brought along security issues. The adoption of OpenFlow Protocol (OFP) by SDN as the way of communication between controllers and switches, has not only brought about easy and direct manipulation of data for enhanced packet forwarding policies, but also renders the network vulnerable to security issues (DDoS attacks) since the OpenFlow (OF) switch has to ask the controller to install new rules for any new incoming packet. In this work, the capability of SDN in handling security threats that arise from the above vulnerability is proven. This work seeks to design and implement a DDoS detection model that uses Hidden Markov Model (HMM) for detecting abnormal traffic (OpenFlow flooding attacks) directed towards the SDN controller aimed at destabilizing the flow of normal network traffic among users in a software-defined networking environment.
Arthroplasty System Long-Term Clinical Outcomes With the Activ-L Lumbar

Background: Low back pain (LBP) due to degenerative disc disease (DDD) is the most common occupational disorder worldwide. Lumbar total disc replacement (LTDR) has provided an alternative to rigid fusion to relieve pain with less motion restriction. We present clinical results with long-term follow-up from a single-center, single-surgeon series of patients treated with the Activ-L artificial disc. Methods: Thirty-three patients with symptomatic single-level DDD who failed nonsurgical therapy for a minimum of 6 months underwent single-level arthroplasty with the Activ-L system between 2007 and 2012. Demographic, preoperative, and postoperative data were collected prospectively. Clinical factors reviewed included occupational status, sensory deficits, functional status determined by Oswestry Disability Index (ODI), back pain, leg pain, pain medication consumption, and radiographic imaging. Results: Average age at surgery was 38.0 6 7.8 years, and the majority of patients were male (60.6%). Average follow-up was 2.7 6 1.7 years. Average ODI at preoperative baseline was 54.6 6 13.5, with scores significantly improved at 6 weeks (28.6 6 17.4, P , .0001), 3 months (24.1 6 16.8, P , .0001), 6 months (22.3 6 16.3, P , .0001), 1 year (18.8 6 15.3, P , .0001), and final follow-up (15.6 6 16.4, P , .0001). Most patients (87.8%) reported pain medication usage within 14 days of baseline evaluation, with consumption decreasing significantly at 1-year (34.5%, P , .0001) and long-term follow-up (21.2%, P , .0001). One patient experienced mild unilateral graft subsidence at 1 year, which remained stable on radiographs at 5 years. None of the prostheses required revision surgery. Conclusions: The Activ-L disc replacement system is safe and effective for treating single-level lumbar DDD. Patients reported significant improvement in functional outcomes and decreases in pain medication consumption. Further investigation of the Activ-L system in larger populations is warranted. Clinical Relevance: LBP is a common cause of disability worldwide, and better treatment options are needed to improve outcomes, including pain and mobility. Spine surgeons may choose the Activ-L disc replacement as a safe and effective treatment for LBP caused by single-level lumbar DDD. Total Disc Replacement
Genetic diversity of Stemphylium vesicarium causing Stemphylium blight of onion from different geographical regions of Kashmir

Stemphylium blight is the most serious and devastating disease of onion limiting the quality and quantity of both bulb and seed. Molecular analysis using 9 RAPD primers was done to assess the genetic diversity among the 36 S. vesicarium isolates from onion obtained from different geographical areas of Kashmir valley. All the 9 RAPD markers used during the present study revealed a moderate level of polymorphism in different isolates of S. vesicarium. In the present study maximum scored bands were 160 in SV-A04 marker with maximum polymorphic bands (10) showing 6.25 per cent polymorphism. The lowest scored bands were 7 in marker “SV-F02” with only two polymorphic bands showing 28.57 per cent polymorphism. In total, 579 bands were scored of which 54 were polymorphic, thereby showing 9.32 per cent polymorphism. Genetic dissimilarity of the isolates varied from 1.00 to 0.14. The present study provides insights into the extent of genetic diversity available in 36 S. vesicarium isolates from onion obtained from different geographical areas of Kashmir valley.
CXCR6 enforced retention promotes resident memory CD8 T cell- mediated immunosurveillance and control of ovarian cancer

1Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.1 2University of Chicago Medicine Comprehensive Cancer Center, Chicago, IL, USA. 3Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL, USA 4Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA 5McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada. 6Department of Immunobiology, College of Medicine, University of Arizona, Tucson, AZ, USA.
Supplementary Materials: Self-Supervised Procedure Learning from Instructional Videos using DNNs

Key-step Localization Network. To build the key-step localization network (KLN), we make connection between our goal, which is to take a T` input vectors and output T` outputs each of dimension M , and semantic image segmentation whose goal is to take an input image and produce an output image where each pixel takes one of few discrete values corresponding to a category. Thus, we take the network in [1] and, given that we are working with sequential data instead of 2D images, we convert 2D convolutions, 2D pooling and 2D deconvolutions to 1D temporal convolutions, 1D pooling and 1D deconvolutions, respectively, see Figure 1.
Spurious rejections by Perron tests in the presence of a misplaced or second break under the null

It is known that Dickey-Fuller tests can lead to spurious rejections of the unit root null hypothesis when the true generating process is difference-stationary with a break. Suppose now that an unsuccessful attempt is made to allow for a break, either through misplaced dummy variables or through neglecting a second break. It is demonstrated that spurious rejections can now occur for a broader set of true break dates than would be the case if the possibility of a break was ignored.
The Factors Affecting Household Electricity Saving Behavior: A Study in Vietnam

In the context of dramatically increase in electricity demand, Vietnam's potential for power supply remains limited. Research and promotion of electricity saving behavior of households become significant to reduce electricity consumption and protect ecological environment. This study incorporates elements of planned behavior theory (TPB) and norm activation model (NAM) as the basis for developing and extending key assumptions. In addition, expansion TPB is used to study influence factors affecting electricity saving behavior. Through a sample of 395 randomly selected residents in Tay Ninh Province and Ho Chi Minh city in Vietnam, the proposals were checked using a structural equation model (SEM). The results showed that the factors in TPB and NAM (such as perceived behavioral control, subjective norm, attitude, personal moral norm) and additional factor (perceived benefit) are the important factors that influence resident's intention of saving electricity. Moreover, electricity saving behavior is strongly influenced by the intention of saving electricity, perceived benefit, policy and social propaganda. Based on these results, some inferences are drawn, and recommendations are made for policy makers and further research proposals are discussed.
Low temperature phase transition induced biaxial negative thermal expansion of 2,4-dinitroanisole

The crystal structure of 2,4-dinitroanisole (24DNAN) is known to have two polymorphic structures (Z′ = 2 and Z′ = 1, hereafter referred to as α-form and β-form, respectively) and the oxygen atoms of the nitro group(s) of both polymorphs have been found to be disordered over two positions at 298 K. In the thermal behaviour studies of 24DNAN, the β-form showed a phase transition at 264.5 K on cooling. To investigate this phase transition variable-temperature single-crystal X-ray diffraction measurements were carried out. The β angle for the β-form dramatically changed from 90.190° (298 K) to 96.716° (100 K). The length of the b axis shows negative thermal expansion, 13.741(5) to 13.810(5) A (with a change in temperature from 298 K to 100 K). The thermal expansion coefficients along the principal axes X1, X2, and X3 are −31(6), −15(7) and 262(20) MK−1 (261–100 K), respectively. 24DNAN showed an unusual biaxial NTE induced by a low temperature phase transition.
Novel Coronavirus (SARS-CoV-2) Main Protease: Molecular docking of Puerarin as a Potential inhibitor

SARS-CoV-2 a single stranded RNA virus which triggered the global pandemic Coronavirus Disease- 2019 (COVID-2019). It has infected about 2,844,712 patients and brought forth mortality rate to about 201,315 among 216 countries as cited by WHO. Drugs including Chloroquine and Hydroxychloroquine derivatives are being administered in most urgent cases; although, with probable side effects to people with metabolic disorders. Thus, unavailability of authorized drugs and treatment for this pandemic demands the research world to discover natural compounds with potency to cure it. This paper assesses the isoflavonoid puerarin from Pueraria lobata as a possible inhibitor of the main protease of SARS-COV-2 (Mpro) via in silico approach, for example molecular docking, Lipinski’s rule of five and toxicity prediction (ADME). Puerarin revealed high binding affinity with the target site of SARS-CoV-2 main protease. This compound slightly meets the criteria of Lipinski’s rule and does not possess properties that could cause adverse effects in humans thus, making puerarin a potential drug candidate to investigate for its usage against COVID-19.