Miracle-dz/UniFAR-FTUs huggingface dataset:
Physiotherapists’ recommendations for examination and treatment of rotator cuff related shoulder pain: A consensus exercise

© 2019 - IOS Press and the authors. All rights reserved. BACKGROUND: Disorders associated with the rotator cuff are regarded as the most common shoulder pain presentation. The range of diagnostic terms used to explain this problem reflect uncertainty in relation to causative mechanisms, diagnosis, prognosis, and the most effective treatments. The aim of this consensus exercise was to facilitate a shared understanding as a means of reducing mixed messages, informing clinical practice and providing a foundation for future research. METHODS: Nine physiotherapists with clinical and academic expertise in shoulder pain participated in an online and face-to-face consensus exercise. RESULTS: This consensus exercise suggests specific factors in the history and physical examination that might raise the index of suspicion of Rotator Cuff Related Shoulder Pain. The suggestions for non-surgical management include a minimal number of exercises prescribed to challenge the functional deficit of the patient over a minimum 12-week period. Apart from aiding exclusion of red flag pathology, imaging is not regarded as useful unless the patient does not respond as expected. Steroid injections wouldn't be considered a first-line intervention unless pain was severe and preventing engagement with exercise. CONCLUSION: This consensus exercise provides a benchmark for clinical reflection while highlighting areas of uncertainty that still exist and require further research.
Pediatric Nutrition Handbook

The new sixth edition of this comprehensive manual on pediatric nutrition has been expanded considerably to reflect new scientific insights. Covering how nutrients influence and direct growth and development, as well as immediate and long-term health, from birth through adolescence, this is a valuable desk reference.This evidence-based manual reflects the current policies and practices recommended by the American Academy of Pediatrics, Committee on Nutrition.The chapters cover: Cultural considerations in feeding children; Nutritional support for children who are neurologically impaired; Anorexia nervosa and bulimia nervosa; Nutrition for children with sickle cell disease; Nutritional management of children with renal disease; Gastrointestinal disease and cardiac disease; and, Nutrition in cystic fibrosis; Food safety: pesticides, industrial chemicals, toxins, food additives, and more. It includes greatly expanded appendices of more than 50 tables including dietary allowances, energy requirements, composition of human milk and infant formulas, food exchanges, and more. It also includes more than 20 growth charts including charts for very low, and low birth weight infants, full-term infants, children and adolescents; and down syndrome growth charts.
Model for a cortical circuit associated with childhood absence epilepsy

Childhood absence epilepsy is suspected to result from mutations in genes which encode ion channels including sodium channels. Our purpose in this thesis is to explore some of the factors that alter the function of neurons in the cerebral cortex. In particular, we investigate the consequence of these alterations on neuronal network activity associated with this disorder. In this regard, we create a small network consisting of deep layer cortical pyramidal neurons and an interneuron, each described by a single-compartment Hodgkin-Huxley style model. We investigate factors that convert a normal network into a hyperexcitable one, including impairment of GABAA synapses and sodium channel defects resulting from mutations in Scn genes. Our model agrees with experimental results indicating the role of GABA impairment in generating a hyperexcitable network. In particular, our cortical network is capable of generating its own spike-and-wave oscillations analogous to those in a thalamocortical network. Our results also suggest that the co-existence of multiple Nachannel mutations alters individual neuronal function to increase or decrease the likelihood of the network exhibiting seizure-like behaviour.
First Nearly Complete Genome Sequence of Porcine Bocavirus Strain from Malaysia

| This paper reports the first nearly complete genome sequence of a Malaysian Porcine bocavirus (PBoV) detected in Malaysia from a porcine organ sample. In Malaysia, both Human bocavirus (HBoV) and PBoV have been reported, at prevalence of 5.6% and 90.9% respectively. Most recently, in 2018, PBoV emerged as a zoonosis when a human case of PBoV-related respiratory infection is reported in a child with history of contact with porcine secretion. With this evidence of human infection with PBoV, considering close contact between humans and pigs in the swine industry, further study of PBoV genetic characterization and epidemiology is warranted. This study attempts to obtain the complete genome sequence of a Malaysian PBoV isolate detected in a pig farm in the state of Selangor. A nearly complete sequence was obtained through primer walking and touchdown PCR method. Based on phylogenetic analysis for the nearly complete genome, the Malaysian PBoV strain is genetically characterized as PBoV G3B, sharing a close relationship with a reference PBoV strain from U.S.A. with 98% homology. This finding may facilitate further epidemiological studies and diagnostic development of PBoV in Malaysia.
Accelerated Texforms: Alternative Methods for Generating Unrecognizable Object Images with Preserved Mid-Level Features

Texforms are images that preserve the coarse shape and texture information of objects, while rendering them unrecognizable at the basic level (Long, Konkle, Cohen, & Alvarez, 2016). These stimuli have been valuable to test whether cognitive and neural processes depend on explicit recognition of the objects. However, to generate these images, the current implementation and computational complexity of the model requires approximately 4-6 hours per object – thus preventing data-hungry experiments that may require generating thousands of texforms. Our contribution in this work includes the introduction of 2 new texform generation methods that accelerate the rendering time from hours to minutes or seconds respectively. The first we call Fast-FS-Texform where we accelerate the rendering time of the Freeman and Simoncelli (2011) model and increase the output resolution by placing a simulated point of fixation outside of the visual field. The second, which we call NeuroFoveaTexform, is an adaptation of the newly proposed metamer model of Deza, Jonnalagadda, and Eckstein (2019) which leverages a VGGNet and foveated style transfer. We show qualitative and quantitative results of both new methods opening the door to data-intensive texform experiments.
Relationship between Intra Ocular Pressure and Visual Acuity in Port Harcourt, Nigeria

Intraocular pressure (IOP) is the fluid pressure inside the eye and the normal value is 10-21 mmHg [1]. Elevated intraocular pressure is a major risk factor for the development of primary open-angle glaucoma, and even in normal tension glaucoma the reduction of IOP may slow the progression of visual field loss [2]. It is the only proven treatable risk factor. People with a high IOP (>21mmHg) with no proof of having primary open-angle glaucoma are considered at risk of developing optic nerve damage, even if they do not suffer from any ocular disease [3]. Different factors like age and sex among others influence IOP [4,5]. Visual acuity is defined as the “spatial resolving capacity” of the eye or, put another way, the size of an object that can be resolved with an eye. It can be measured by identifying the angle subtended at the eye by the smallest recognizable optotype. Theoretically, this represents macular function, but really it represents the state of the entire ocular system, including the visual pathways [6]. In practice, measurement of visual acuity is performed using specialized eye *Corresponding author: Chibuike Sydney Ejimadu, Department of Ophthalmology, University of Port Harcourt, Nigeria. Received Date: May 17, 2019 Published Date: May 28, 2019 ISSN: 2641-6360 DOI: 10.33552/WJOVR.2019. 02.000529
Physical Training Combined with Dietary Measures and Acupuncture in the Treatment of Adult Obesity. A Comparison of Two Protocols

Obesity is a frequent pathology with a multitude of complications; over the last few decades, it has become an increasingly significant public health concern in both developed and developing countries. The aim of our work was to compare two types of treatment protocols to determine the efficiency of physical training and dietary measures with acupuncture or electroacupuncture in management of obese females. Forty obese females participated in the study and were included in two equal groups. The first group (A) received physical training combined with dietary measures and acupuncture. The second group (B) received physical training combined with dietary measures and electroacupuncture. The program consisted of three sessions per week for three months. There was a significant decrease in Body Mass Index (BMI), Waist Circumference (WC), Hip Circumference (HC), Waist Hip Ratio (WHR), blood Leptin, Total Cholesterol (TC), Low Density Lipoprotein Cholesterol (LDL-c) and Triglycerides (TG) and increase in High Density Lipoprotein Cholesterol HDL-c in both groups after treatments, but the changes in group (B) were greater than in group (A). However, there was no significant difference between mean levels of the investigated parameters in group (B) and group (A) post- therapy. So, physical training and dietary measures with electroacupuncture can be used as methods of choice for management of obese females.
Imagerie de population et IRM de diffusion pour caractériser la sclérose en plaques pour la moélle épinière humaine. (Population imaging and diffusion MRI for characterizing multiple sclerosis in the human spinal cord)

Quantitative MRI has huge potential to provide intrinsic and normative value to tissue properties useful for diagnosis, prognosis and ultimately clinical trials in multiple sclerosis (MS) which is an inflammatory disorder of the central nervous system. Complementary to brain imaging, investigating how the spinal cord is damaged using quantitative imaging, and in particular diffusion MRI, becomes an acute challenge. Acquiring and processing this type of data present inherent challenges due to the susceptibility distortion, the small crosssectional area of the spine and the lack of visible anatomical landmarks to help identification of tracts or vertebral level. In this context, we propose several contributions for the processing and statistical analysis of this data. First, we propose novel geometric metrics to evaluate and compare different distortion correction methods by measuring the alignment of the reconstructed diffusion model with the apparent centerline of the spine. Second, using a cohort of MS patients and healthy controls, we study the link between diffusion measures and the presence or absence of lesion in a given vertebral level and we show that we can predict the latter with good accuracy by learning a multivariate linear classifier. Last, we show the feasibility of longitudinal study of the evolution of diffusion MRI metrics by performing a reproducibility study using a test-retest dataset and apply it to the 2 first timepoints (M0 and M12) of our cohort of MS patients.
Non-Coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases

We conducted genome sequencing to search for rare variation contributing to early onset Alzheimer’s disease (EOAD) and frontotemporal dementia (FTD). Discovery analysis was conducted on 493 cases and 671 controls of European ancestry. Burden testing for rare variation associated with disease was conducted using filters based on variant rarity (less than 1 in 10,000 or private), computational prediction of deleteriousness (CADD 10 or 15 thresholds), and molecular function (protein loss-of-function only, coding alteration only, or coding plus non-coding variants in experimentally predicted regulatory regions). Replication analysis was conducted on 16,871 independent cases and 15,941 independent controls. Rare variants in TET2 were enriched in the discovery combined EOAD and FTD cohort (p=6.5×10−8, genome-wide corrected p=0.0037). Most of these variants were canonical loss-of-function or non-coding in predicted regulatory regions. This enrichment replicated across several cohorts of AD and FTD (replication only p=0.0071). The combined analysis odds ratio was 2.2 (95% CI 1.5–3.2) for AD and FTD. The odds ratio for qualifying non-coding variants considered independently from coding variants was 2.1 (95% CI 1.2–3.9). For loss-of-function variants, the combined odds ratio (for AD, FTD, and amyotrophic lateral sclerosis, which shares clinicopathological overlap with FTD) was 3.2 (95% CI 2.0–5.3). TET2 catalyzes DNA demethylation. Given well-defined changes in DNA methylation that occur during aging, rare variation in TET2 may confer risk for neurodegeneration by altering the homeostasis of key aging-related processes. Additionally, our study emphasizes the relevance of non-coding variation in genetic studies of complex disease.
Double-Shelled Brace to Correct Spinal Deformity in Non-Ambulatory Patients with Cerebral Palsy A STROBE-Compliant Study

Introduction: The generally accepted incidence of scoliosis in cerebral palsy (CP) is 20% to 25% and is directly related to the Gross Motor Function Classification System (GMFCS) level. One treatment option for neurogenic scoliosis is a double-shelled brace (DSB). The aim of this study was to investigate the degree of correction achieved when using three different replica techniques. Materials and Methods: We included a consecutive series of 25 CP patients (8 boys, 15 girls) in this retrospective study. Mean age was 13.0 years (range: 4.0 to 20.0 years). All participants were non-ambulatory (GMFCS levels IV and V). The degree of immediate correction was expressed in percent of the lumbar and thoracic COBB angles. Results: At the level of the lumbar spine, we found a mean (± SD) curve of 45.7° (19.2°). Mean correction with the DSB was 20.9° (13.1°; p<0.05). This represents an improvement of 49.9% At the level of the thoracic spine, we determined a mean curve of 40.5° (17.8°). In all the cases, we measured the immediate correction. Mean correction with the DSB was 13.8° (10.3°; p<0.05). This represents an improvement of 33.1%. All three replica techniques achieved a statistically significant correction (p<0.05) of the COBB angles at both levels. Conclusions: Double-shelled bracing provides an excellent immediate correction of neurogenic scoliosis in cerebral palsy. Further studies are required to investigate long-term outcomes.
Handbook of Psychiatry in Palliative Medicine

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EVALUATION OF A SCALE ABOUT FEMALE PROPENSITY TO UNDERGO COSMETIC SURGERY

This paper is about scale’s development and evaluation, created to measure the women’s propensity to undergo cosmetic surgery. A sample of 697 students from a large public Brazilian university to evaluate the scale was used. The propensity to undergo cosmetic surgery scale is proposed to measure someone’s intention or desire to have cosmetic surgery. The scale has 6 items obtained from the translation of items available in the Marketing Scale’s field. The sample was divided by 2 and exploratory and confirmatory factor analysis has been used to analyze data. The result shows that the scale is unidimensional, has validity and reliability (α=0.91). The scale can be used by scholars in future research and assist professionals and businesses related to the beauty industry in the segmentation of possible target audiences.
From the Inside Out: A Literature Review on Possibilities of Mobile Emotion Measurement and Recognition

Information systems are becoming increasingly intelligent and emotion artificial intelligence is an important component for the future. Therefore, the measurement and recognition of emotions is necessary and crucial. This paper presents a state of the art in the research field of mobile emotion measurement and recognition. The aim of this structured literature analysis using the PRISMA statement is to collect and classify the relevant literature and to provide an overview of the current status of mobile emotion recording and its future trends. A total of 59 articles were identified in the relevant literature databases, which can be divided into four main categories of emotion measurement. There was an increase of publications over the years in all four categories, but with a particularly strong increase in the areas of optical and vital-data-based recording. Over time, both the speed as well as the accuracy of the measurement has improved considerably in all four
Prediction of time of delivery using cervical length measurement in women with threatened preterm labor

Abstract Objective To evaluate the use of transvaginal (TV) sonographic cervical length (CL) measurement alone in predicting time of delivery in women who present in threatened preterm labor. Methods A retrospective cohort study at Royal Brisbane and Women’s Hospital of all women who presented between 22 weeks and 0 days and 35 weeks and six-day gestation in threatened preterm labor and were admitted for ongoing management including a TV sonographic CL measure. The accuracy of CL for predicting time of delivery was compared between women with a short cervix (CL < 25 mm) and those with a normal cervix (CL ≥25 mm). The predictive accuracy of CL for spontaneous preterm delivery was analyzed with different outcome-specific thresholds. Results One hundred and forty-six women with threatened preterm labor met the inclusion criteria; of which 74 (50.7%) had a short cervix and 72 (49.3%) had a normal cervix. The group with short cervix were more likely to deliver prematurely before 37-week gestation, as well as a shorter time interval between initial presentation and delivery and delivery within 14 days from presentation (p = .0002, p = .0001, and p = .0001, respectively). Similarly, with respect to the area under the receiver operator characteristic curves, CL measurement was found to be significant for time of delivery before or after 37 weeks (p < .0001), preterm delivery before 34 (p = .0003) and 31 (p < .0001) weeks; and preterm delivery within 14 days from presentation (p < .0001). Cervical length measurement has a high negative predictive value ranging from 94.9 to 97.1% depending on the different CL threshold used. Conclusions Cervical length measurement at the time of presentation was significantly associated with the risk of preterm delivery in women presenting with threatened preterm labor and a short cervix. Cervical length measurement was also helpful in predicting time of delivery within 14 days from presentation. The negative predictive value and predictive accuracy of CL as a single measure were of significance.
The Honolulu heart program : an epidemiological study of coronary heart disease and stroke

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Molecular epidemiology and antimicrobial resistance of invasive non-typhoidal Salmonella in China, 2007–2016

Purpose Human infections caused by invasive non-typhoidal Salmonella (iNTS) are highly prevalent worldwide. However, data for such infections in China are scarce. This study reports the epidemiology of iNTS in China. Methods INTS isolates were recovered from blood and other clinical specimens collected during 2007–2016 across five provinces (Shanghai, Xinjiang, Fujian, Guangxi, and Chongqing) in China. Antimicrobial susceptibility was performed using the agar dilution method and molecular epidemiology was performed using standard microbiological techniques. Results A total of 178 iNTS isolates were recovered from approximately 9700 patient specimens during 2007–2016. The predominant serovars were Salmonella Enteritidis (57/178, 32%), Salmonella Choleraesuis (47/178, 26.4%), and Salmonella Typhimurium (24/178, 13.5%). Up to 50 isolates (28.1%) were from patients who were ≤1 year of age, while 28 (15.7%) were from patients who were ≥60 years. Among these isolates, high rates of resistance to nalidixic acid (114/178, 64%), sulfisoxazole (59%), ciprofloxacin (15.2%), and cefotaxime (8.4%) were found. Moreover, 53.4% (95/178) exhibited multidrug resistance, and 3.9% (7/178) showed co-resistance to third-generation cephalosporins and ciprofloxacin. Steadily increasing numbers of nalidixic acid, cefotaxime, and ciprofloxacin-resistant isolates, but decreasing numbers of multidrug resistance isolates were detected during the study period. Detection of quinolone genes in 114 nalidixic acid-resistant isolates showed that 58.3% (67/114) harbored plasmid-mediated quinolone resistance (PMQR) genes [aac(6´)-Ib-cr, qnrA, qnrB, oqxAB, qepA, qnrS, and qnrD] and 98.2% (112/114) exhibited mutations in quinolone resistance determining regions [gyrA, parC, and parE]. Furthermore, we detected beta-lactamases genes in the ceftriaxone-resistant isolates. The most common were blaTEM-1 (93.3%), followed by blaCTX-M-55 (40%), blaCMY-2 (33.3%), and blaOXA-1 (33.3%). Finally, a range of pulsed-field gel electrophoresis patterns were detected among the Salmonella Enteritidis and Salmonella Typhimurium isolates. Conclusion High rates of multidrug resistance and steadily increasing cefotaxime and ciprofloxacin-resistant iNTS could pose a significant challenge for the effective treatment of salmonellosis in China.
Characterization of the ecophysiological responses of three pomegranate cultivars to salinity

In order to understand photosynthetic responses of pomegranate plants (Punica granatum L.) to salinity, an experiment was conducted with three varieties, 'Mollar de Elche', 'Valenciana', and 'Wonderful', irrigated with seven salt concentrations (0, 40, 60, 80, 100, 120, and 140 mM NaCl). At the end of the experiment, parameters of gas exchange, chlorophyll fluorescence, water relations, and sugar and chloride concentrations were measured in leaves. As the concentration of NaCl increased, the concentration of Cl- in leaves was elevated, and the CO2 assimilation rate, stomatal conductance, variable fluorescence/maximum fluorescence ratio, PSII quantum yield, and total soluble sugars decreased. In 'Valenciana', the decrease of the net assimilation of CO2 could occur due to the closure of stomata, while in 'Mollar' and 'Wonderful', this was due to damage caused by Cl- toxicity. The study of carbohydrates also suggests a different behavior of carbon metabolism in the three varieties.