Epidemiology: Study Design and Data Analysis

PREFACE FUNDAMENTAL ISSUES What is Epidemiology? Case Studies: The Work of Doll and Hill Populations and Samples Measuring Disease Measuring the Risk Factor Causality Studies Using Routine Data Study Design Data Analysis Exercises BASIC ANALYTICAL PROCEDURES Introduction Case Study Types of Variables Tables and Charts Inferential Techniques for Categorical Variables Descriptive Techniques for Quantitative Variables Inferences about Means Inferential Techniques for Non-Normal Data Measuring Agreement Assessing Diagnostic Tests Exercises ASSESSING RISK FACTORS Risk and Relative Risk Odds and Odds Ratio Relative Risk or Odds Ratio? Prevalence Studies Testing Association Risk Factors Measured at Several Levels Attributable Risk Rate and Relative Rate Measures of Difference Exercises CONFOUNDING AND INTERACTION Introduction The Concept of Confounding Identification of Confounders Assessing Confounding Standardization Mantel-Haenszel Methods The Concept of Interaction Testing for Interaction Dealing with Interaction Exercises COHORT STUDIES Design Considerations Analytical Considerations Cohort Life Tables Kaplan-Meier Estimation Comparison of Two Sets of Survival Probabilities The Person-Years Method Period-Cohort Analysis Exercises CASE-CONTROL STUDIES Basic Design Concepts Basic Methods of Analysis Selection of Cases Selection of Controls Matching The Analysis of Matched Studies Nested Case-Control Studies Case-Cohort Studies Case-Crossover Studies Exercises INTERVENTION STUDIES Introduction Ethical Considerations Avoidance of Bias Parallel Group Studies Cross-Over Studies Sequential Studies Allocation to Treatment Group Exercises SAMPLE SIZE DETERMINATION Introduction Power Testing a Mean Value Testing a Difference Between Means Testing a Proportion Testing a Relative Risk Case-Control Studies Complex Sampling Designs Concluding Remarks Exercises MODELLING QUANTITATIVE OUTCOME VARIABLES Statistical Models One Categorical Explanatory Variable One Quantitative Explanatory Variable Two Categorical Explanatory Variables Model Building General Linear Models Several Explanatory Variables Model Checking Confounding Longitudinal Data Non-Normal Alternatives Exercises MODELLING BINARY OUTCOME DATA Introduction Problems with Standard Regression Models Logistic Regression Interpretation of Logistic Regression Coefficients Generic Data Multiple Logistic Regression Models Tests of Hypotheses Confounding Interaction Model Checking Regression Dilution Case-Control Studies Outcomes with Several Ordered Levels Longitudinal Data Complex Sampling Designs Exercises MODELLING FOLLOW-UP DATA Introduction Basic Functions of Survival Time Estimating the Hazard Function Probability Models Proportional Hazards Regression Models The Cox Proportional Hazards Model The Weibull Proportional Hazards Model Model Checking Poisson Regression Pooled Logistic Regression Exercises META-ANALYSIS Reviewing Evidence Systematic Review A General Approach to Pooling Investigating Heterogeneity Pooling Tabular Data Individual Participant Data Dealing with Aspects of Study Quality Publication Bias Is Meta-Analysis a Valid Tool in Epidemiology? Exercises APPENDIX A: MATERIALS AVAILABLE FROM THE WEBSITE APPENDIX B: STATISTICAL TABLES APPENDIX C: EXAMPLE DATA SETS SOLUTIONS TO EXERCISES REFERENCES INDEX