Miracle-dz/UniFAR-FTUs huggingface dataset:
Anti-Obesity Efficacy of Pediococcus acidilactici MNL5 in Canorhabditis elegans Gut Model

In the present study, thirty two lactic acid bacteria (LAB) were isolated from fermented Indian herbal medicine. In comparison to other strains, MNL5 had stronger bile salt hydrolase (BSH) and cholesterol-lowering properties. Furthermore, it can withstand the extreme conditions found in the GI tract, due to, e.g., pepsin, bile salts, pancreatin, and acids. Pediococcus acidilactici MNL5 was identified as a probiotic candidate after sequencing the 16S rRNA gene. The antibacterial activity of P. acidilactici MNL5 cell-free supernatants (CFS) against Escherichia coli, Staphylococcus aureus, Helicobacter pylori, Bacillus cereus, and Candida albicans was moderate. A Caenorhabditis elegans experiment was also performed to assess the effectiveness of P. acidilactici MNL5 supplementation to increase life span compared to E. coli supplementation (DAF-2 and LIU1 models) (p < 0.05). An immense reduction of the lipid droplets of C. elegans was identified through a fluorescent microscope. The drastic alteration of the expression of fat genes is related to obesity phenotypes. Hence, several paths are evolutionary for C. elegans; the results of our work highlight the nematode as an important model for obesity.
Breast Reconstruction by Exclusive Lipofilling after Total Mastectomy for Breast Cancer: Description of the Technique and Evaluation of Quality of Life

Background: The objective of this work was to describe the technique of exclusive lipofilling in breast reconstruction after total mastectomy, to evaluate the satisfaction and quality of life of the patients, and to explore current literature on the subject. Methods: We conducted a retrospective observational multicentric study from January 2013 to April 2020. The modalities of surgery, esthetic result, and patient satisfaction were evaluated with the breast reconstruction module of BREAST-Q. Results: Complete data were available for 37 patients. The mean number of sessions was 2.2 (standard deviation 1.1), spread over an average of 6.8 months (SD 6.9). The average total volume of fat transferred was 566.4 mL. The complication rate was 18.9%. No severe complication was observed (Clavien–Dindo 3/4). Two patients were diagnosed with recurrence, in a metastatic mode (5.4%). The average satisfaction rate was 68.4% (SD 24.8) for psychosocial well-being and 64.5% (SD 24.1) for sexual well-being. The satisfaction rate was 60.2% (SD 20.9) for the image of the reconstructed breast and 82.7% (SD 21.9) for locoregional comfort. Conclusions: Breast reconstruction by exclusive lipofilling after total mastectomy provides satisfactory quality of life scores. The simplicity of the surgical technique and equipment required, and the high satisfaction rate confirm that lipofilling should be included in the panel of choice of breast reconstruction techniques.
Analysis of different z-score data to the neural network for automatic FSR vehicle classification

A combination of Z-score and Neural Network is use as part of the FSR vehicles classification system. The classification performance of different inputs to NN is evaluated. The input of NN will be the data that give positive number of Z-score and Z-score values. The results of vehicle classification for three different frequencies which are fixed at 64 MHz, 151 MHz and 434 MHz are presented and discussed. The result shows the relevancy of the proposed technique is effective in performing ground target classification. The result also indicates the data that provide the positive number of Zscore is the best input for classification of FSR ground target.
Development and Evaluation of Liquid Plaster Loaded with Chromolaena odorata Leaf Extract Endowed with Several Beneficial Properties to Wound Healing

Liquid plaster (LP) is a recently developed wound dressing product that can be used to cover wounds in various parts of the body, especially small injuries or wounds in body parts involved in movement. Given the benefits and applications of LP, this study aimed to develop and evaluate Chromolaena odorata extract-loaded LP with antimicrobial and hemostasis effects. The study was first conducted through the extraction of Choromolaena odorata leaf by using an ethanol maceration technique and identification of the compounds with high-performance liquid chromatography. The LP loaded with Chromolaena odorata extract demonstrates an ability to inhibit S. aureus and S. epidermidis at a MIC of 0.25 mg/mL and MBC of 0.5 mg/mL. The antioxidant activity test was performed by ABTS and DPPH methods demonstrating the free-radical scavenging activity of the extract. The blood clotting activity was established by varying the concentration of Choromolaena odorata leaf extract from 0.0625 mg/mL to 1 mg/mL. The formulation of the film-forming system was developed by varying the solvent, polymer, and plasticizer proportions. The optimum formulation displayed fast film-forming with high elasticity of the film. Moreover, the 20 mg/mL herbal extract-loaded LP provided an antibacterial effect with admissible water vapor transmission and low skin irritation. As a result, the study demonstrates the possibility of introducing the Chromolaena odorata extract-loaded LP to increase the effectiveness of wound healing and the antibacterial effect on the skin.
Archaeology International Research Articles and Updates Citizenship and religion in the first-millennium bce Mediterranean: from Etruria to Iberia

This short contribution summarises an impending research project that will be carried as part of the 2021–22 Distinguished Fellowship programme at the Max-Weber-Kolleg (University of Erfurt) within the research cluster Religion and Urbanity. The aim of the project is to contribute to a comparative understanding of first-millennium bce Mediterranean urbanism by focusing on citizenship, through the inves-tigation of the archaeological record of ritual contexts in two selected regions: southern Tyrrhenian Etruria and southeastern Iberia. The project builds on recent research on comparative urbanism and the role of religion in urban life, from Greek history to interdisciplinary studies on religion. The particular focus will be to understand whether, and the extent to which, religion provided the conceptual and material space for expressing membership to the urban community or, in one word, citizenship.
Three-dimention Route Planning of Aircraft Based on Ant Genetic Algorithm

As a part of mission planning system,route planning is the key technology of autonomous control. In order to quickly get the best route with less braking nodes,this paper proposed an ant genetic algorithm to solve the 3-D route planning of aircraft,which combines the ant algorithm with the genetic algorithm on the basis of describing the problem of route planning. This paper designed route evaluation function with variance and built a method of construction of programming model based on plan. In this programming model,this paper discussed the species initialization of genetic algorithm,construction of fitness function and the use of genetic operator in detail. At last,the algorithm flow was given. Simulation results demonstrate the effectiveness and validity of the algorithm.
Dogmatic, instrumental and paradoxical frames: A pragmatic research framework for studying organizational sustainability

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Blood-Based Biomarkers for Alzheimer’s Disease in Older Adults with Posttraumatic Stress Disorder

Background: Posttraumatic stress disorder (PTSD) is associated with cognitive decline and risk for dementia, but the neuropathology involved is unclear. Objective: The aim of this study was to determine whether PTSD is associated with increased levels of Alzheimer’s disease (AD) blood-based biomarkers. Methods: Individuals aged 50 years and older with PTSD were compared to trauma-exposed healthy controls (TEHCs) at baseline on serum measures of amyloid-β (Aβ) 42 and 40 levels, the Aβ42/Aβ40 ratio, and total tau. Serum was analyzed using ultrasensitive Simoa Human Neurology 3-Plex A assay (N3PA). Linear regressions modeling each AD biomarker as a function of group were used to investigate between-group differences, controlling for age, sex, and educational attainment (years). Results: TEHC participants (N = 26) were 53.8% male with mean age 66.8±10.7, whereas PTSD participants (N = 44) were 47.7% male and aged 62.5±9.1 years. No between-group differences were noted on demographic characteristics or cognitive performance measured with the NIH Toolbox Cognition Battery. There were no significant between-group differences in serum Aβ40 (TEHC 105.8±51.6 versus PTSD 93.2±56.1, p = 0.46), Aβ42 (TEHC 8.1±4.6 versus PTSD 7.8±4.6, p = 0.63), Aβ42/Aβ40 (TEHC 0.08±0.03 versus PTSD 0.09±0.03, p = 0.27), or total tau (TEHC 0.5±0.3 versus PTSD 0.5±0.4, p = 0.77). Likewise, there were no significant interaction effects of amyloid or tau serum concentrations and PTSD group status on cognitive functioning. Conclusion: Findings from cognitive assessments and serum analyses do not support PTSD-induced neurodegeneration of the Alzheimer’s type as a pathway linking PTSD to increased incidence of dementia in older adults.
3D Location Optimization for UAV-Aided Uplink/Downlink Transmissions

In this paper, we investigate the placement of an unmanned aerial vehicle (UAV) base station (BS) which serves multiple ground users (GUs). By taking into account both the uplink and downlink transmissions, we aim to optimize the 3D location of the UAV for maximizing the minimum average sum rate. The 3D location optimization problem is divided into the horizontal coordinate and the height optimization subproblems, respectively. We further apply the CVX toolbox to solve the horizontal coordinate optimization problem and transform the height optimization problem into the elevation angle optimization problem to obtain its solution. Our numerical results show that the minimum average sum rate of the proposed 3D location optimization scheme is higher than that of the numerical search (NS) based location optimization method, that of the energy-efficient maximal coverage (EEMC) based location optimization method and that of the random location method, for different distributions of GUs’ locations.
A Rapid LC-MS/MS Method for Simultaneous Determination of Ten Flavonoid Metabolites of Naringin in Rat Urine and Its Application to an Excretion Study

Naringin is a dietary flavonoid glycoside with multiple bioactivities. It has been involved in numerous metabolism and excretion studies, and its metabolic properties are clear. However, information concerning the excretion profile of its original metabolites are still scarce, and few methods for simultaneous determination of multiple original metabolites of naringin in biological samples have been reported so far. In this study, a rapid and sensitive method for simultaneous determination of ten flavonoid metabolites of naringin in rat urine was developed with an UHPLC-Q-Trap-MS/MS system. One-step protein precipitation method with acetonitrile was used to extract analytes. A rapid chromatographic separation within 11 min was performed on an ACQUITY UPLC® BEH C18 column (2.1 mm × 50 mm, 1.7 μm) using gradient elution with a mobile phase of water and methanol, both with 0.1% formic acid (v/v). MS/MS detection was conducted in negative ion mode and multiple reactions monitoring scanning mode. The analytical method was fully validated and successfully applied to monitor the excretion profiles of naringin in rat urine. Quantitative results revealed the visible individual difference and low urinary recovery of flavonoid metabolites in the excretion of naringin, which may be helpful for further study to understand the in vivo behavior and action mechanism of naringin.
The relationship between social support and psychological well-being of college students during Covid-19 pandemic

One of those affected by the COVID-19 pandemic is college students. It made the learning process that was previously carried out face-to-face became online. This condition affects the psychological well-being of college students. One of the factors that influence psychological well-being is social support. The goal of this research is to investigate the relationship between social support and the psychological well-being of college students during the COVID-19 pandemic. The method used in this research was a quantitative method with a correlational design. A total of 351 college students who attend lectures during the COVID-19 pandemic and studied in the city of Padang, West Sumatra, Indonesia became a subject of this research. Measurement was carried out by adapting the scale and each scale has a reliability of . 795 and . 894. The results showed that social support was significantly related to the psychological well-being of college students during the COVID-19 pandemic which could be seen from the significance value of . 00 (p<.05). The Pearson correlation value in the research was . 668, this indicates that the relationship between social support and the psychological well-being of college students during the COVID-19 pandemic is in a strong category.
Hydrangea macrophylla and Thunberginol C Attenuate Stress-Induced Anxiety in Mice

Stress is an important neurological input for successful life. However, chronic stress and stress hormones could be a cause of various neurological disorders including anxiety disorders. Therefore, there have been many efforts to find effective materials for curing stress-induced neurological disorders. In this study, we examined the effect of Hydrangea macrophylla (HM) on corticosterone-induced neurotoxicity, stress-induced anxiety in mice and suggested a possible active ingredient of HM. HM protected cortical neurons against neurotoxicity of corticosterone (CORT), a stress hormone. HM also blocked CORT-induced hippocampal synaptic deficit via regulating Akt signaling. Oral administration of HM improved chronic restraint stress-induced anxiety in Elevated Plus maze test along with reduction of plasma corticosterone and TNF-α levels. Moreover, HM reduced stress-induced neuroinflammation and oxidative stress. Thunberginol C, an active ingredient of HM, also prevented CORT-induced neuronal cell death and restraint stress-induced anxiety. Moreover, thunberginol C reduced plasma TNF-α level and neuroinflammation and oxidative stress. Collectively, HM could be a good candidate for preventing stress-induced neurological disorders and thunberginol C may be an active ingredient of HM for this purpose.
ON LAMINATE SELECTION AND DESIGN

Composite materials, at one level, are exciting to work with because they give scope for designing the “material” in addition to a “structure” through judicious placement of the orientation of plies. It is their ability to tailor material properties layer by layer that give designers huge potential in design. One possible explanation for the prevalent use of quasiisotropic (“black aluminium”) carbon composites in structures is the lack of available design tools. Here a design tool is presented that aids selection of fibre orientations. Optimisation of laminate fibre angles is difficult for multiple load cases and objectives-there are many local minima to assess. An alternative approach to complex / numerical optimisation methods, is presented here The basic idea is to build a database that stores appropriate properties of all permutations of lay-up angles for a laminate. The designer can select viable laminates by first plotting a succession of 2-D charts containing relevant properties. Then, using simple on-screen techniques, the number of potential laminates is visually reduced by selecting those with desirable properties. Two case studies are presented. The first concerns the optimisation of a spar web, typically found in an aircraft wing structure whilst the second considers the optimisation of a cylindrical shell, subject to axial compression, that undergoes simultaneous Euler-type buckling and local buckling. Nomenclature
Gaussian Accelerated Molecular Dynamics Simulations Investigation on the Mechanism of Angiotensin-Converting Enzyme (ACE) C-Domain Inhibition by Dipeptides

Angiotensin-converting enzyme (ACE)-inhibitory peptides extracted from food proteins can lower blood pressure by inhibiting ACE activity. A recent study showed that the inhibitory activity of IY (Ile-Tyr, a dipeptide derived from soybean protein) against ACE was much higher than that of LL (Leu-Leu), although they had similar hydrophobic and predicted activity values. It was difficult to reveal the deep molecular mechanism underlying this phenomenon by traditional experimental methods. The Apo and two complex systems (i.e., ACE–LL and ACE–IY) were therefore subjected to 1 μs long Gaussian accelerated molecular dynamics (GaMD) simulations. The results showed that the binding of IY can cause obvious contraction of the active site of ACE, mainly manifested by a significant lateral shift of α13, α14, and α15. In addition, hinge 2 and hinge 3 were more stable in the ACE–IY system, while these phenomena were not present in the ACE–LL system. Moreover, the α10 of the IY-bound ACE kept an inward state during the simulation progress, which facilitated the ACE to remain closed. However, for the LL-bound ACE, the α10 switched between two outward states. To sum up, our study provides detailed insights into inhibitor-induced conformational changes in ACE that may help in the design of specific inhibitors targeting ACE for the treatment of hypertension.
System-on-chip design of multi-axis servo controller

The digital control algorithms and design techniques of multi-axis servo system-on-chip integration are investigated in this paper.On the basis of vector control and servo system design principle,high efficiency IP cores of FOC and servo controllers were created,including coordinate transformation,velocity measurement,SVPWM,inverse-time protection,PID regulator,electronic gear,feed-forward controller,filters,etc.In addition,the timing controller was developed via reasonable scheduling of these algorithm cells.According to the idea of time-division multiplex,the high-powered SoC of multi-axis servo controller was finally implemented on an advanced FPGA platform,incorporating with various IP modules as well as a RISC microprocessor.Experimental results show that the designed single-chip system can receive analog or digital command,or pulse-type instruction,with configuration of different operation mode for torque,speed or position control;furthermore,each axis is independent of the others,and all parameters are programmable on line.
Parallel Operation of Permanent Magnet Generators and Diode Rectifiers in Maritime DC Power System Considering Fuel Economy

The dc grid system is attracting attention as a new electric power distribution method for several vessel kinds due to its high fuel efficiency compared with the ac grid. The combination of a wound rotor generator (WRG) and a diode rectifier [diode front end (DFE)] has been typically applied as a generation part of the dc grid. Still, the combination of a permanent magnet generator (PMG) and a DFE has been recently studied to take advantage of their simplicity, cost-effectiveness, robustness, high reliability, and high efficiency. However, although a single-operation mode of the “PMG + DFE” system was analyzed in the literature, research for the parallel operation of the “PMG + DFE” system has not yet been conducted. The “PMG + DFE” system should be operated along the optimal operating line (OOL) in the power–voltage (<inline-formula> <tex-math notation="LaTeX">$P$ </tex-math></inline-formula>–<inline-formula> <tex-math notation="LaTeX">$V$ </tex-math></inline-formula>) domain to minimize fuel consumption. This OOL in the <inline-formula> <tex-math notation="LaTeX">$P$ </tex-math></inline-formula>–<inline-formula> <tex-math notation="LaTeX">$V$ </tex-math></inline-formula> domain includes negative, zero, and positive slopes under light, medium, and heavy loads, respectively. Therefore, if the conventional droop control is applied to this system, it cannot be operated along the OOL. This article introduces modified droop control for operating paralleled “PMG + DFE” system along the OOL in the <inline-formula> <tex-math notation="LaTeX">$P$ </tex-math></inline-formula>–<inline-formula> <tex-math notation="LaTeX">$V$ </tex-math></inline-formula> domain. Furthermore, a mode change strategy from the single-operation mode to the parallel-operation mode is proposed. The validity of the proposed modified droop control is verified by computer simulation and a small-scaled experimental test.
The Effect of Nanoparticle-Incorporated Natural-Based Biomaterials towards Cells on Activated Pathways: A Systematic Review

The advancement of natural-based biomaterials in providing a carrier has revealed a wide range of benefits in the biomedical sciences, particularly in wound healing, tissue engineering and regenerative medicine. Incorporating nanoparticles within polymer composites has been reported to enhance scaffolding performance, cellular interactions and their physico-chemical and biological properties in comparison to analogue composites without nanoparticles. This review summarized the current knowledge of nanoparticles incorporated into natural-based biomaterials with effects on their cellular interactions in wound healing. Although the mechanisms of wound healing and the function of specific cells in wound repair have been partially described, many of the underlying signaling pathways remain unknown. We also reviewed the current understanding and new insights into the wingless/integrated (Wnt)/β-catenin pathway and other signaling pathways of transforming growth factor beta (TGF-β), Notch, and Sonic hedgehog during wound healing. The findings demonstrated that most of the studies reported positive outcomes of biomaterial scaffolds incorporated with nanoparticles on cell attachment, viability, proliferation, and migration. Combining therapies consisting of nanoparticles and biomaterials could be promising for future therapies and better outcomes in tissue engineering and regenerative medicine.
Incidence and Distribution of Four Viruses Causing Diverse Mosaic Diseases of Sugarcane in China

Mosaic diseases of sugarcane caused by various viruses have been reported in most sugarcane planting countries and threaten global sugar production. There is a lack of extensive, systematic investigation of mosaic diseases and their causal viruses in China. In this study, a total of 901 leaf samples showing mosaic symptoms were collected from commercial fields in eight provincial regions in China and tested for sorghum mosaic virus (SrMV), sugarcane mosaic virus (SCMV), sugarcane streak mosaic virus (SCSMV), and maize yellow mosaic virus (MaYMV) using RT-PCR with four specific primer pairs. Of 901 tested samples, 38.5% (347/901) of samples were infected with one of the four viruses alone. Infection by two or more viruses was seen for 42.6% (384/901) of samples. The highest incidence of virus-causing sugarcane mosaic disease was SrMV (70.1%), followed by SCMV (33.4%) and SCSMV (30.3%), and the lowest incidence was seen for MaYMV (5.1%). Three viruses (SrMV, SCMV, and SCSMV) were found in eight sugarcane-planting provinces, whereas MaYMV was only found in Fujian, Guangxi, and Sichuan provinces. Mixed infections of the three main viruses, particularly for SrMV + SCMV and SrMV + SCSMV, were commonly found in the sugarcane samples. Our systematic determination of the occurrence and distribution of four RNA viruses associated with sugarcane mosaic diseases can provide evidence to guide the development of strategies for the prevention and control of sugarcane mosaic diseases in China.