Miracle-dz/UniFAR-FTUs huggingface dataset:
Cardiovascular , Pulmonary , and Renal Pathology DR 3 Signaling Protects against Cisplatin Nephrotoxicity Mediated by Tumor Necrosis Factor

The expression of death receptor 3 (DR3), a member of the tumor necrosis factor (TNF) receptor superfamily, is up-regulated in human tubular epithelial cells (TECs) during renal injury, but its function in this setting remains unknown. We used cisplatin to induce renal injury in wildtype (DR3 / ) or congenitally deficient DR3 / mice to examine the in vivo role of DR3. Cisplatin induced the expression of DR3, its ligand, TNF-like ligand 1A (TL1A), and TNF in TECs, as observed in human renal injury. Cisplatin increased apoptotic death of DR3 / TECs by twofold compared with DR3 / TECs, whereas it reduced the number of tubules expressing phospho-NFBp65 by 50% at 72 hours. Similar degrees of induction of DR3, TL1A, and TNF, and changes in apoptosis and phosphoNFBp65, were obtained in mouse kidney organ cultures treated with cisplatin for 3 hours, suggesting a direct effect on TECs. TNF was implicated in mediating cisplatininduced tubular damage given that the in vivo co-administration of GM6001, an inhibitor of TNF maturation and release, significantly reduced TNF production and tubular damage. Moreover, TNF exacerbated, whereas TL1A reduced, cisplatin-induced apoptosis in the DR3 / mouse proximal tubule cell line, TKPTS. Our data demonstrate that cisplatin-induced nephrotoxicity is mitigated by DR3 signaling, suggesting that this occurs by antagonizing pro-apoptotic signals induced by TNF. Therefore, activating DR3 may be beneficial in reducing acute kidney injury. (Am J Pathol 2012, 180:1454–1464; DOI: 10.1016/j.ajpath.2012.01.003)
AIE EDAM : Articial Intelligence for Engineering Design , Analysis , and Manufacturing

The logic of typed feature structures is a sorted description logic that has enjoyed widespread usage in grammar design for the last 20 years. Woodbury and Burrow have faithfully preserved its strengths in adapting it to design space navigation research, although the weaknesses it has exhibited in the context of natural language grammar design are likely to surface here as well.
Are MTCs tethering complexes or trafficking complexes that may act as tethers ?

Since the late 1990s, a number of multisubunit tethering complexes (MTCs) have been described that function in membrane trafficking events: TRAPP I, TRAPP II, TRAPP III, COG, HOPS, CORVET, Dsl1, GARP and exocyst. Based mainly on structural and sequence similarities, they have been categorized as complexes associated with tethering containing helical rods (CATCHR) (Dsl1, COG, GARP, exocyst) or non-CATCHR (TRAPP I, II and III, HOPS, CORVET) complexes (1). Both acronyms (CATCHR and MTC) imply these complexes tether opposing membranes to facilitate fusion. The main question we will address is: have these complexes been formally demonstrated to function as tethers? If the answer is no, then is it premature or even correct to refer to them as tethers? In this commentary, we will argue that the vast majority of MTCs have not been demonstrated to act as a tether. We propose that a distinction between the terms tether and tethering factor be considered to address this issue. Membrane traffic is a process that ensures the correct complement of proteins and lipids reach the appropriate cellular compartment. It is recognized that a number of different types of protein machinery must act in concert to achieve this by directing vesicular carriers to the correct destination. These factors include SNARE proteins, vesicle coat proteins, Ypt/Rab GTPases and a class of factors referred to as tethers (2). Traditionally, tethers have been classified into two broad groups: (i) coiled-coil proteins and (ii) multisubunit tethering complexes (MTCs) (1,3). Based on both structural and sequence similarities between the subunits of some of these complexes, the MTCs have in turn been subcategorized into CATCHR (complexes associated with tethering containing helical rods ) and non-CATCHR complexes (1). Inherent in these acronyms is the presumption that these complexes tether membranes. This raises the question: how strong is the evidence that each of the nine MTCs is a tether in the strict sense of the word? In order to address this question, we will define a tether as a protein or complex that physically links two distinct membranes to each other. These membranes could be two vesicles or two identical organelles such as vacuoles (i.e. homotypic fusion) or a vesicle with a target organelle (i.e. heterotypic fusion). Much of the work on the MTCs has been performed in yeast and we will focus on that system. However, we will also discuss higher eukaryotes when evidence is
Long short-term memory network for heart rate prediction and exercise training load determination using wrist-worn acceleration and heart rate signals in elite runners

Questo studio propone un modello per la ricostruzione del battito cardiaco durante sessioni di allenamento di corsa, qualora il segnale ottenuto tramite sensori ottici sia corrotto, a causa di artefatti da movimento, dal contatto non ottimale pelle-sensore, per la temperatura dell’ambiente, per la presenza di sangue venoso e per il colore della pelle. Infatti negli ultimi anni, si e’ verificato un exploit nel mercato sportivo di sensori ottici indossabili al polso per il monitoraggio del battito cardiaco che ha portato allo sviluppo di una nuova tecnologia economica, portatile e comoda. La convenienza nell’avere tutto in un unico dispotivo pero’ va a spese dell’accuratezza stessa del dispositivo che potrebbe portare eventualmentente ad una non corretta valutazione del battito cardiaco. Se per atleti dilettanti che corrono a scopo ricreativo cio’ potrebbe anche risultatre accettabile, per corridori professionali il monitoraggio del battito cardiaco non puo’ essere compromesso. Cio’ e’ dovuto all’esistenza del rapporto tra battito cardiaco e intensita’ dell’esercizio. Conoscere l’intensita’ dell’esercizio e del carico di lavoro svolto e’ di vitale importanza per corridori professionali, al fine di evitare gravi lesioni al corpo e migliorare la performance fisica. Per questo motivo, in questo studio verra’ testata la fattibilita’ di predire accuratamente il battito cardiaco con l’aiuto di un accelerometro e di un sensore ottico attraverso una tipologia di rete neurale chiamata Long Short-Term Memory (LSTM) network, cioe’ una rete neurale basata su una memoria a lungo e breve termine. Tale rete e’ in grado di risolvere problemi legati alle serie temporali irrisolvibili con le tradizionali reti neurali, e permette di fare riconoscimenti vocali, traduzioni linguistiche, riconoscimenti in immagini e video, ed appunto predizioni di serie temporali. La predizione del battito cardiaco sara’ seguita dalla determinazione del carico di lavoro svolto.
Well-Being, Romantic Relationships and Lay Theories

Relationships are considered critical to subjective well-being. In particular, aspects of friendships and spousal relationships are positively correlated with well-being including happiness. Limited research on the contribution of romantic dating relationships to well-being suggests a positive correlation as well (Demir, 2008). The present study investigated the contribution of romantic relationships to well-being including whether this contribution is mediated by personality. Unlike some previous research, which relied on modified measures of friendship to assess important characteristics of romantic relationships, undergraduate students were asked about dimensions of their relationships that were exclusively romantic (e.g., sexual intimacy). Additionally, the perceived contribution of romantic relationships was studied by assessing lay theories (beliefs of the general population about the contribution of romantic relationships to well-being). Lay theories of the relation between romantic relationships and well-being varied as a function of romantic relationship characteristics, and these lay theories agreed with the empirical findings of the relation between romantic relationships and wellbeing. Additionally, the present study found there were specific characteristics of romantic relationships that predict well-being and that the results differed as a function of gender.
Fixed Costs, Foreign Direct Investment, and Gravity with Zeros

Fixed costs play a crucial role in current models of foreign direct investment (FDI), yet they are almost entirely ignored in empirical treatments of FDI. We fill this gap by using a 1989–2001 panel of FDI flows into Iceland to examine the determinants of fixed costs for multinational firms and how these influence aggregate patterns of investment. Our additions to research in the field include usage of several natural-resource variables, and the analysis of data on initial entry of FDI into a developed country. We use the Heckman two-step procedure, which allows us to account for fixed costs and their impact on estimation. Taken together, we find that the standard OLS approach to the data incorrectly links the quantity of FDI to source-country variables while in fact most of their role is in determining whether FDI takes place at all.
Vector-Coupled Flight Controller Design Based on Multivariable Backstepping Sliding Mode

This study aims to address the issues of the simultaneous control of the angle of attack, sideslip angle, and airspeed of a flight in a vectorial form. A vector controller, with a symmetry structure, is developed to transform the attitude and speed control problem into a space-vector tracking problem. We first establish flight vector-coupled dynamics, i.e., describe velocity and angular-velocity vectors in a body-fixed frame, and then propose a multivariable backstepping sliding mode control algorithm along with nonlinear disturbance observers for the vectorial dynamics. The theoretical analysis ensures that the states of the system can be enforced to reach a small neighborhood of the desired sliding manifold. The results of the numerical simulation illustrate the effectiveness and robustness of the combined vector-control scheme.
Databases and ontologies Pln 24 NT : a web resource for plant 24-nt siRNA producing loci

In plants, 24 nucleotide small interfering RNAs (24-nt siRNAs) account for a large percentage of the total siRNA pool, and they play an important role in guiding plant-specific RNA-directed DNA methylation (RdDM), which transcriptionally silences transposon elements, transgenes, repetitive sequences and some endogenous genes. Several loci in plant genomes produce clusters of 24-nt RNAs, and these loci are receiving increasing attention from the research community. However, at present there is no bioinformatics resource dedicated to 24-nt siRNA loci and their derived 24-nt siRNAs. Thus, in this study, Pln24NT, a freely available web resource, was created to centralize 24-nt siRNA loci and 24-nt siRNA information, including fundamental locus information, expression profiles and annotation of transposon elements, from next-generation sequencing (NGS) data for 10 popular plant species. An intuitive web interface was also developed for convenient searching and browsing, and analytical tools were included to help users flexibly analyze their own siRNA NGS data. Pln24NT will help the plant research community to discover and characterize 24-nt siRNAs, and may prove useful for studying the roles of siRNA in RNA-directed DNA methylation in plants. Availability and Implementation: http://bioinformatics.caf.ac.cn/Pln24NT. Contact: suxh@caf.ac.cn Supplementary information: Supplementary data are available at Bioinformatics online.
Comparison of Germans and Spaniards Lay Theories toward Cancer and Myocardial Infarction : A Transcultural

The objective of this study was a transcultural comparison regarding illness-related causal and control attributes using a survey of healthy Germans in Germany, Spaniards in Spain and Spaniards in Germany. Each group contained 100 persons, matched according to sex, age and education. Germans showed more pronounced internal causal as well as control beliefs while Spaniards in Germany showed fatalistic attribution and Spaniards in Spain placed more emphasis on social aspects. It was possible to correctly assign over 75 percent of persons to a group depending on their characteristics in terms of causal and control attributions. Considerations of cultural and migration-related factors regarding public health appear especially promising.
INVITRO ANTI-INFLAMMATORY AND ANTI-ARTHRITIC PROPERTY OF RHIZOPORA MUCRONATA LEAVES

The present investigation was carried out the evaluation of the anti-arthritic property of Rhizophora mucronata by three different methods viz., membrane stabilization assay, protein denaturation assay and albumin denaturation assay. Four different concentration of test (100, 200, 300 and 400 mg) were using in this study. Action was observed in dose dependent manner. In protein denaturation method at 400 mg of chosen extract showed maximum protection (97.56%) and standard drug provided 99.2% protection. Similarly, in membrane stabilization test, the selected extract at concentration of 400 mg showed maximum protection (95%) and standard drug provided 97% protection. Moreover, albumin denaturation test showed maximum protection (90.12%) at concentration of 400 mg. We concluded that, methanolic extract of Rhizophora mucronata shows strong anti-arthritic activity at different concentration when compared to standard drug of Diclofenac sodium. In addition, phytochemical analysis of Rhizophora mucronata showed the presence of saponins, flavanoids, tannins, anthracene, phenols, aminoacids and sugars. It reveals that these phytochemical constituents are responsible to maximum protection of protein denaturation, albumin denaturation and membrane stabilization assay. The future work will be determination of anti-inflammatory and anti-arthritic activities by in vivo models.
Communicating across cultures in South African law courts: Towards an information technology solution

Language rights in South Africa are entrenched in the Constitution of South Africa (Chapter 1, Section 6, Constitution of the Republic of South Africa, 1996). However, the concomitant infrastructure and organisational realities make this policy difficult to implement, especially in law courts (Kaschula and Ralarala 2004). Creating effective communicative environments has historically been constrained by lack of effective training of legal practitioners and by the lack of capacity for building translation structures. With the advancement of technology, potential solutions are becoming more apparent and it is incumbent upon the academic community to embark on a rigorous investigation into possible solutions and how these Information Communication Technology (ICT) solutions could be applied to the execution of justice in South African law courts. This article aims to open the discourse of possible solutions, via assessments of computer based translation solutions, ICT context simulations and other potential opportunities. The authors hope to initiate the interest of other language and legal practitioners to explore how the new technological capabilities could be harnessed to support the entrenchment of language rights in our law courts.
DENTAL IMPLANTS and Pitt De Pitt of Mc Pitt Bio Mc Pitt of Regeneration of PeriosteumbyHuman Bone Marrow Stromal Cell Sheets

Purpose: The presence of a functional periosteum accelerates healing in bone defects by providing a source of progenitor cells that aid in repair. We hypothesized that bone marrow stromal cell (BMSC) sheets could be used to engineer functional periosteal tissues. Materials and Methods: BMSCs were cultured to hyperconfluence and produced sufficient extracellular matrix to form robust tissue sheets. The sheets were wrapped around calcium phosphate pellets and implanted subcutaneously in mice for 8 weeks. Histologic comparisons were made between calcium phosphate samples with and without BMSC sheet wraps. Bone and periosteum formation were analyzed through tissue morphology and tissue-specific protein expression. Results: Calcium phosphate pellets wrapped in BMSC sheets regenerated a bone-like tissue, but pellets lacking the cell sheet wrap did not. The bone-like tissue seen on the calcium phosphate scaffolds wrapped with the BMSC sheets was enclosed within a periosteum-like tissue characterized morphologically and through expression of periostin. Conclusions: These data indicate that cell sheet technology has potential for regenerating a functional periosteum-like tissue that could aid in future orthopedic therapy. 2014PublishedbyElsevier Inconbehalfof theAmericanAssociationofOralandMaxillofacial Surgeons J Oral Maxillofac Surg 72:1078-1083, 2014
Effects of seasonal change in Osinmo reservoir on arginase and rhodanese activities in Clarias gariepinus Burchell and Heterotis niloticus Cuvier

This work reports the seasonal change and variation in the physico-chemical properties of the water in Osinmo reservoir in Southwestern Nigeria and the effects on tissue distribution of the metabolic enzymes, arginase and rhodanese are the two fish species ( Clarias gariepinus and Heterotis niloticus ) collected from the reservoir. This study was carried out to correlate the activities of the enzymes with metabolic status of the fishes and physico-chemical properties of the water. The enzyme activities varied significantly in the different tissues of the C. gariepinus . The liver showed the highest mean value of activity and the intestine had the least mean value. In the H. niloticus , they showed the highest mean value of activity while the bile showed the lowest mean value. The activities of the two enzymes in the water reservoir were determined at regular intervals over a period of ten months in 2011, spanning both dry and rainy seasons. The activities of the enzymes varied significantly through the two seasons. Arginase was at its peak in June while rhodanese was at its peak in September. The distribution of urea in the reservoir varied significantly in the period studied; the highest mean value was in July while the lowest was in February.
STUDENTS’ PERCEPTIONS OF MATHEMATICS INTERVENTION COURSES

In this study I investigated the perceptions of first year mathematics students towards an alternative mode of delivery intervention programme at the University of Namibia. The alternative mode intervention programme implements a slower pace of teaching, accommodating student needs and background gaps. Lecturers developed specific teaching strategies that afforded students individual attention, greater interaction, mediation and tutorial sessions. I report on the students’ and lecturers’ responses to focus group discussions and interviews respectively. Students identified that mathematical proficiency was central to their learning, and pedagogical knowledge and exploratory talk were critical aspects of good teaching in a mathematical intervention programme.
AN INDICATOR FOR ECOSYSTEM EXTERNALITIES IN FISHING

Ecosystem externalities arise when one use of an ecosystem affects its other uses through the production functions of the ecosystem. We use simulations with a size‐spectrum ecosystem model to investigate the ecosystem externality created by fishing of multiple species. The model is based upon general ecological principles and is calibrated to the North Sea. Two fleets are considered: a “forage fish” fleet targeting species that mature at small sizes and a “large fish” fleet targeting large piscivorous species. Based on the marginal analysis of the present value of the rent, we develop a benefit indicator that explicitly divides the consequences of fishing into internal and external benefits. This analysis demonstrates that the forage fish fleet has a notable economic impact on the large fish fleet, but the reverse is not true. The impact can be either negative or positive, which entails that for optimal economic exploitation, the forage fishery has to be adjusted according to the large fish fishery. With the present large fish fishery in the North Sea, the two fisheries are well adjusted; however, the present combined exploitation level is too high to achieve optimal economic rents.
Type : Reserch paper Short title : Violet light has protective effect against myopia Word count : 167

Please cite this article as: Torii, Hidemasa, Kurihara, Toshihide, Seko, Yuko, Negishi, Kazuno, Ohnuma, Kazuhiko, Inaba, Takaaki, Kawashima, Motoko, Jiang, Xiaoyan, Kondo, Shinichiro, Miyauchi, Maki, Miwa, Yukihiro, Katada, Yusaku, Kato, Keiichi, Tsubota, Kinya, Goto, Hiroshi, Oda, Mayumi, Hatori, Megumi, Tsubota, Kazuo, Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression, EBioMedicine (2016), doi: 10.1016/j.ebiom. 2016.12. 007
How can the decommodified security ratio assess social protection systems

With a view to better assessment of the roles played by social security and social policy in determining well-being, this presentation introduces the ”decommodified security ratio“ (DSR), an instrument for evaluating an important duty of the social State, namely to maintain and improve people's economic security. To that end we describe the conventions for its use and analyse its main components in 24 countries in 1999-2001, by using the wave V of Luxembourg Income Survey database. From an analysis of the sources of economic security we then distinguish five different rationales.
Genetic Diversity and Relationships in Local Varieties of Eggplant from Different Cultivar Groups as Assessed by Genomic SSR Markers

Spain is a secondary center of diversity for eggplant (Solanum melongena). Spanish landraces of eggplant are normally classified in four cultivar groups: Round, Listada de Gandia, Semi-Long, and Long. We have used 19 genomic SSRs for the molecular characterization of 30 eggplant accessions corresponding to the four cultivar groups. Sixteen SSRs of which 15 were polymorphic could be amplified and 65 polymorphic alleles, with a range of two to 11 alleles/locus, were detected. The polymorphism information content (PIC) of SSR markers ranged from 0.07 to 0.77, with an average value of PIC=0.50. The mean observed heterozygosity (Ho) presented a very low value Ho=0.01, while the mean expected heterozygosity (He) had a value of He=0.57. Multivariate cluster analyses revealed that a considerable diversity exists within each of the cultivar groups. Listada de Gandia and Long cultivar groups were clearly separated from each other in different branches of phenogram. The principal coordinates analysis (PCoA) confirmed that each of the cultivar groups is genetically diverse and, with the exception of the Round group, they plot in different areas of the PCoA graph. Overall, the results indicate that Spanish eggplant landraces present a high degree of homozygosis, considerable intra-cultivar group diversity, and a certain degree of genetic differentiation. This information is of interest for selection and breeding of eggplant as well as for germplasm conservation.
Cell Stem Cell Surviving Epithelial Cells Repair Injured Kidney

Benjamin D. Humphreys,1,3,* M. Todd Valerius,2 Akio Kobayashi,2 Joshua W. Mugford,2 Savuth Soeung,1 Jeremy S. Duffield,1 Andrew P. McMahon,2,3,* and Joseph V. Bonventre1,3,4,* 1Renal Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Institutes of Medicine, Room 550, 4 Blackfan Circle, Boston, MA 02115, USA 2Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Room BL1059 3Harvard Stem Cell Institute, 42 Church Street Cambridge, MA 02138, USA 4Harvard-MIT Division of Health Sciences and Technology, Building E25, 77 Massachusetts Avenue, Cambridge, MA 02139, USA *Correspondence: bhumphreys@partners.org (B.D.H.), amcmahon@mcb.harvard. edu (A.P.M.), joseph_bonventre@hms.harvard. edu (J.V.B.) DOI 10.1016/j.stem. 2008.01. 014