Miracle-dz/UniFAR-FTUs huggingface dataset:
Depression, Stress and the Mediating Role of Intimate Partner Violence (IPV) Among Israeli Women of Childbearing Age in the Shadow of the COVID-19 Pandemic

Dealing with the outbreak of the new coronavirus has generated unprecedented challenges around the world, including in Israel. Women of childbearing age may be forced to live under particularly difficult circumstances during the pandemic. The current study among Israeli women of childbearing age has three main objectives related to the specific period of the COVID-19 pandemic: to study the prevalence and predictors of intimate partner violence (IPV); to investigate the prevalence and predictors of depression; to examine whether IPV mediates the association between general stress, fear of COVID-19 and depression as an outcome. In a cross-sectional study, 722 married women, Jewish and Arab residents of Israel, were recruited to answer an online self-completion questionnaire during the first wave of the COVID-19 pandemic. The questionnaire included an assessment of their degree of general stress and depression, fear of COVID-19, experiences of IPV and demographic variables. The results of the current study show that a high percentage of women reported IPV (with Muslim women reporting higher IPV than Jewish women), perceived stress (PSS), perceived COVID-19 stress and depression. The findings also show that IPV and its three dimensions mediate the relationship between COVID-19 stress and depression, such that higher stress was related to higher IPV, raising the odds for depression. Moreover, the total scores for IPV and emotional violence were found to mediate the relationship between stress and depression. That is, domestic violence explains part of the association between stress and depression during the COVID-19 pandemic. Indeed, the current pandemic has resulted in an increase in IPV and depression, and especially in the specific stress associated with the disease itself. Based on the findings of the current study, preventing violence will reduce stress-related depression. The Muslim population, and especially those who are more religious, is in particular need of intervention.
Dynamic Co-Embedding Model for Temporal Attributed Networks

In this article, we study the problem of embedding temporal attributed networks, with the goal of which is to learn dynamic low-dimensional representations over time for temporal attributed networks. Existing temporal network embedding methods only learn the representations for nodes, which are unable to capture the dynamic affinities between nodes and attributes. Moreover, existing co-embedding methods that learn the static embeddings of both nodes and attributes cannot be naturally utilized to obtain their dynamic embeddings for temporal attributed networks. To address these issues, we propose the dynamic co-embedding model for temporal attributed networks (DCTANs) based on the dynamic stochastic state–space framework. Our model captures the dynamics of a temporal attributed network by modeling the abstract belief states representing the condition of the nodes and attributes of current time step, and predicting the transitions between temporal abstract states of two successive time steps. Our model is able to learn embeddings for both nodes and attributes based on their belief states at each time step of the temporal attributed network, while the state transition tendency for predicting the future network can be tracked and the affinities between nodes and attributes can be preserved. Experimental results on real-world networks demonstrate that our model achieves substantial performance gains in several static and dynamic graph mining applications compared with the state-of-the-art static and dynamic models.
Sogatella furcifera Saliva Mucin-like Protein Is Required for Feeding and Induces Rice Defences

The white-backed planthopper (WBPH), Sogatella furcifera, is one of the most important piercing-sucking pests of rice (Oryza sativa) in Asia. Mucin-like salivary protein (SFMLP) is highly expressed in the salivary glands of WBPH, which plays an important role in WBPH feeding. In this study, WBPH injected with dsSFMLP had difficulty in sucking phloem sap from rice plants, which significantly reduced their food intake, weight, and survival. In contrast, the knockdown of the SFMLP gene had only a marginal effect on the survival of WBPH fed an artificial diet. Further studies showed that silencing SFMLP resulted in the short and single-branched salivary sheaths secretion and less formation of salivary flanges in rice. These data suggest that SFMLP is involved in the formation of the salivary sheath and is essential for feeding in WBPH. Overexpression of the SFMLP gene in rice plants promoted the feeding of WBPH, whereas silencing the gene in rice plants significantly decreased WBPH performance. Additionally, it was found that overexpression of SFMLP in rice plants elicited the signalling pathway of SA (salicylic acid) while suppressing JA (jasmonic acid); in contrast, silencing of the SFMLP gene in rice plants showed the opposite results. This study clarified the function of SFMLP in WBPH feeding as well as mediating rice defences.
Ammonia concentrations, litter quality, performance and some welfare parameters of broilers kept on different bedding materials

ABSTRACT 1. Litter quality has been related to broiler performance, behaviour, welfare, dust and ammonia (NH3) emissions. Drier litter leads to a reduction in NH3 emissions and reduces the formation of foot- and hock lesions. However, maintaining good litter quality is often challenging. This study investigated the effects of different bedding materials on litter quality and NH3 concentrations at litter level, broiler performance, foot- and hock lesions, plumage cleanliness and breast skin irritation. 2. A total of 2160 Ross 308 male broilers were randomly assigned to 36 floor pens. There were six replications for each of the following six litter treatments: wood shavings, flax, peat, maize silage, chopped wheat straw and flax pellets. 3. For the total period, the highest feed intake and body weight was obtained for broilers housed on peat. The NH3 concentrations measured at litter level was highest for peat and chopped wheat straw at 36 d of age and numerically the lowest for flax at 30 and 36 d of age. Maize silage remained friable, but did not result in lower NH3 concentrations compared to wood shavings. Chopped wheat straw and wood shavings gave rise to the highest incidence of foot lesions at 38 d of age, while broilers kept on flax, peat, maize silage and flax pellets had the lowest incidence of foot lesions at the end of the rearing period. 4. The results of the current study suggest a complicated relationship between the type of bedding material, litter conditions and NH3 volatilised from the litter.
Low-Order Models of Atmospheric Circulations,

Abstract : Low-order models (LOM's), which are systems of ordinary differential equations which have been simplified by extreme reduction of the number of dependent variables, are often capable of representing atmospheric processes in a qualitatively correct manner. With a LOM it is generally possible to obtain a much more extended time-dependent solution, or a much larger ensemble of solutions, than would be economically feasible with a larger model. A general procedure for constructing LOM's is described. A selection of LOM's is presented, to illustrate the many forms which these models may take and the many uses to which they may be put. The step-by-step construction of a LOM is illustrated with a model of the large-scale circulation of a moist atmosphere.
Embryo selection through non-invasive preimplantation genetic testing with cell-free DNA in spent culture media: a protocol for a multicentre, double-blind, randomised controlled trial

Introduction Morphological evaluation is used to select embryos for in vitro fertilisation. However, it does not fully reflect the implantation potential. Preimplantation genetic testing for aneuploidies (PGT-A) can detect embryonic aneuploidy, but biopsy procedure is invasive. Currently, a non-invasive PGT (ni-PGT) approach using spent medium is being evaluated. However, the clinical benefit of ni-PGT has not been clearly demonstrated. A multicentre randomised trial is needed to verify whether ni-PGT can be an new effective tool for evaluating embryos. Methods and analysis Overall, 1148 couples aged 35~42 (women) receiving in vitro fertilization–intracytoplasmic sperm injection are planned to be enrolled. Couples will be digitally randomised to (1) ni-PGT and (2) conventional morphology groups at a 1:1 treatment ratio. The primary outcome will be the ongoing pregnancy rate related to the first transfer cycle within 6 months after oocyte retrieval. Ethics and dissemination The study protocol is approved by the Ethics Committee of Peking University Third Hospital and the participating hospitals. The results will be disseminated through international conferences and scientific journals. Trial registration number NCT04339166.
Exploration of Diazaspiro Cores as Piperazine Bioisosteres in the Development of σ2 Receptor Ligands

A series of σ2R compounds containing benzimidazolone and diazacycloalkane cores was synthesized and evaluated in radioligand binding assays. Replacing the piperazine moiety in a lead compound with diazaspiroalkanes and the fused octahydropyrrolo[3,4-b] pyrrole ring system resulted in a loss in affinity for the σ2R. On the other hand, the bridged 2,5-diazabicyclo[2.2. 1]heptane, 1,4-diazepine, and a 3-aminoazetidine analog possessed nanomolar affinities for the σ2R. Computational chemistry studies were also conducted with the recently published crystal structure of the σ2R/TMEM97 and revealed that hydrogen bond interactions with ASP29 and π-stacking interactions with TYR150 were largely responsible for the high binding affinity of small molecules to this protein.
Sexual Dimorphism in Brown Adipose Tissue Activation and White Adipose Tissue Browning

The present narrative review gathers the studies reported so far, addressing sex differences in the effects of cold exposure, feeding pattern and age on brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning. In rodents, when exposed to decreasing temperatures, females activate thermogenesis earlier. Results obtained in humans go in the same line, although they do not provide results as solid as those obtained in rodents. Regarding the effects of overfeeding, interesting sex differences on BAT thermogenic capacity have been reported, and the greater or lower sensitivity of each sex to this dietary situation seems to be dependent on the type of feeding. In the case of energy restriction, females are more sensitive than males. In addition, sex differences have also been observed in thermogenesis changes induced by phenolic compound administration. During sexual development, an increase in BAT mass and BAT activity takes place. This phenomenon is greater in boys than in girls, probably due to its relation to muscle-mass growth. The opposite situation takes place during ageing, a lifespan period where thermogenic capacity declines, this being more acute in men than in women. Finally, the vast majority of the studies have reported a higher susceptibility to developing WAT browning amongst females. The scarcity of results highlights the need for further studies devoted to analysing this issue, in order to provide valuable information for a more personalised approach.
Successful treatment of metastatic fibrosarcomatous dermatofibrosarcoma protuberans with imatinib mesylate

Dermatofibrosarcoma protuberans (DFSP) is a fibrohistiocytic tumor characterized by a high risk of local recurrence but a low risk of metastasis. A small subpopulation of DFSP undergoes fibrosarcomatous (FS) change, and approximately 15%–57% of cases of DFSP with FS change metastasizes, leading to a poor prognosis. In this report, a case of metastatic FS‐DFSP that was successfully treated with imatinib mesylate in which the IHC staining pattern of recurrent DFSP was quantitatively analyzed in primary and metastatic DFSP areas, is described. Importantly, the recurrent area was composed of two IHC staining patterns (CD34low PD‐L1high Ki67high, and CD34high PD‐L1low Ki67low pattern), while the metastatic area showed a clonal pattern (CD34high PD‐L1low Ki67intermediate) in the present case. In this report, we described a case of metastatic fibrosarcomatous DFSP successfully treated with imatinib mesylate. This case suggests a subpopulation of DFSP with a favorable metastatic pattern.
Automatically Annotated Dataset of a Ground Mobile Robot in Natural Environments via Gazebo Simulations

This paper presents a new synthetic dataset obtained from Gazebo simulations of an Unmanned Ground Vehicle (UGV) moving on different natural environments. To this end, a Husky mobile robot equipped with a tridimensional (3D) Light Detection and Ranging (LiDAR) sensor, a stereo camera, a Global Navigation Satellite System (GNSS) receiver, an Inertial Measurement Unit (IMU) and wheel tachometers has followed several paths using the Robot Operating System (ROS). Both points from LiDAR scans and pixels from camera images, have been automatically labeled into their corresponding object class. For this purpose, unique reflectivity values and flat colors have been assigned to each object present in the modeled environments. As a result, a public dataset, which also includes 3D pose ground-truth, is provided as ROS bag files and as human-readable data. Potential applications include supervised learning and benchmarking for UGV navigation on natural environments. Moreover, to allow researchers to easily modify the dataset or to directly use the simulations, the required code has also been released.
The Sensory Auricular Branch of the Facial Nerve and its Relationship to Landmarks of the Facial Recess

Objective: Delineate the anatomic relationship of the sensory auricular branch (SAB) of the facial nerve to other structures of the facial recess. Methods: Ten adult cadaveric temporal bones were randomly selected and dissected under operative microscopy. Linear and angular measurements were obtained for the following parameters: (1) the distance from the tip of the short process of the incus to the point of convergence of the SAB and the main trunk of the facial nerve; (2) the distance from the point of convergence of the SAB and the main trunk of the facial nerve to the chorda tympani (CT) division from the main trunk; (3) the distance from the bifurcation of the CT and facial nerve to the crossover point of the SAB/CT; (4) the angle at which the SAB merges with the main trunk (Y°), and (5) the angle at which the CT divides off the main trunk (X°). Results: The mean distance from the tip of the short process of the incus to the SAB takeoff was 8.7 ± 1.83 mm (range 6-13 mm). The mean distance from the SAB to the CT division from the main trunk was 5.9 ± 2.41 mm (range 3-10 mm). The mean angle at which the SAB merged with the main trunk of the facial nerve was 38.5 ± 12.63° (range 25°-68°). The mean CT-main trunk angle was 16 ± 4.24° (range 8°-21°). The branching point of the SAB from the facial nerve approximately bisected the facial recess. Conclusion: Recognizing the SAB and knowing its relationships to surrounding anatomy provides a useful adjunctive landmark for the identification of the main trunk of the facial nerve’s mastoid segment. Level of evidence: 4.
Exploring pharmacological inhibition of Gq/11 as an analgesic strategy

Misuse of opioids has greatly affected our society. One potential solution is to develop analgesics that act at targets other than opioid receptors. These can be used either as stand‐alone therapeutics or to improve the safety profile of opioid drugs. Previous research showed that activation of Gq/11 proteins by G‐protein coupled receptors has pro‐nociceptive properties, suggesting that blockade of Gq/11 signalling could be beneficial for pain control. The aim of this study was to test this hypothesis pharmacologically by using potent and selective Gq/11 inhibitor YM‐254890.
New horizons in developing cell lysis methods: A review

Cell lysis is an essential step in many studies related to biology and medicine. Based on the scale and medium that cell lysis is carried out, there are three main types of the cell lysis: (1) lysis of the cells in the surrounding environment, (2) lysis of the isolated or cultured cells, and (3) single cell lysis. Conventionally, several cell lysis methods have been developed, such as freeze‐thawing, bead beating, incursion in liquid nitrogen, sonication, and enzymatic and chemical‐based approaches. In recent years, various novel technologies have been employed to develop new methods of cell lysis. The aim of studies in this field is to introduce more precise and efficient tools or to reduce the costs of cell lysis procedures. Nanostructure‐based lysis methods, acoustic oscillation, electrical current, irradiation, bacteria‐mediated cell lysis, magnetic ionic liquids, bacteriophage genes, monolith columns, hydraulic forces, and steam explosion are some examples of newly developed cell lysis methods. Besides the significant advances in this field, there are still many challenges and tools must be further improved.
Short-Term Changes in Serum Potassium and the Risk of Subsequent Vascular Events and Mortality

Visual Abstract Background and objectives Hyperkalemia after starting renin-angiotensin system inhibitors has been shown to be subsequently associated with a higher risk of cardiovascular and kidney outcomes. However, whether to continue or discontinue the drug after hyperkalemia remains unclear. Design, setting, participants, & measurements Data came from the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial, which included a run-in period where all participants initiated angiotensin-converting enzyme inhibitor–based therapy (a fixed combination of perindopril and indapamide). The study population was taken as patients with type 2 diabetes with normokalemia (serum potassium of 3.5 to <5.0 mEq/L) at the start of run-in. Potassium was remeasured 3 weeks later when a total of 9694 participants were classified into hyperkalemia (≥5.0 mEq/L), normokalemia, and hypokalemia (<3.5 mEq/L) groups. After run-in, patients were randomized to continuation of the angiotensin-converting enzyme inhibitor–based therapy or placebo; major macrovascular, microvascular, and mortality outcomes were analyzed using Cox regression during the following 4.4 years (median). Results During active run-in, 556 (6%) participants experienced hyperkalemia. During follow-up, 1505 participants experienced the primary composite outcome of major macrovascular and microvascular events. Randomized treatment of angiotensin-converting enzyme inhibitor–based therapy significantly decreased the risk of the primary outcome (38.1 versus 42.0 per 1000 person-years; hazard ratio, 0.91; 95% confidence interval, 0.83 to 1.00; P=0.04) compared with placebo. The magnitude of effects did not differ across subgroups defined by short-term changes in serum potassium during run-in (P for heterogeneity =0.66). Similar consistent treatment effects were also observed for all-cause death, cardiovascular death, major coronary events, major cerebrovascular events, and new or worsening nephropathy (P for heterogeneity ≥0.27). Conclusions Continuation of angiotensin-converting enzyme inhibitor–based therapy consistently decreased the subsequent risk of clinical outcomes, including cardiovascular and kidney outcomes and death, regardless of short-term changes in serum potassium. Clinical Trial registry name and registration number: Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE), NCT00145925
THC-RPL: A lightweight Trust-enabled routing in RPL-based IoT networks against Sybil attack

The Internet of Things (IoT) and its relevant advances have attracted significant scholarly, governmental, and industrial attention in recent years. Since the IoT specifications are quite different from what the Internet can deliver today, many groundbreaking techniques, such as Mobile Ad hoc Networks (MANETs) and Wireless Sensor Networks (WSN), have gradually been integrated into IoT. The Routing Protocol for Low power and Lossy network (RPL) is the de-facto IoT routing protocol in such networks. Unfortunately, it is susceptible to numerous internal attacks. Many techniques, such as cryptography, Intrusion Detection System (IDS), and authorization have been used to counter this. The large computational overhead of these techniques limits their direct application to IoT nodes, especially due to their low power and lossy nature. Therefore, this paper proposes a Trust-based Hybrid Cooperative RPL protocol (THC-RPL) to detect malicious Sybil nodes in an RPL-based IoT network. The proposed technique is compared and evaluated with state-of-the-art and is found to outperform them. It detects more attacks while maintaining the packet loss ratio in the range of 15-25%. The average energy consumption of the nodes also remains in the ratio of 60-80 mj. There is approximately 40% more energy conservation at node level with an overall 50% increase in network lifetime. THC-RPL has 10% less message exchange and 0% storage costs.
A New Interactive Tool to Visualize and Analyze COVID-19 Data: The PERISCOPE Atlas

Since the start of the 21st century, the world has not confronted a more serious threat to global public health than the COVID-19 pandemic. While governments initially took radical actions in response to the pandemic to avoid catastrophic collapse of their health care systems, government policies have also had numerous knock-on socioeconomic, political, behavioral and economic effects. Researchers, thus, have a unique opportunity to forward our collective understanding of the modern world and to respond to the emergency situation in a way that optimizes resources and maximizes results. The PERISCOPE project, funded by the European Commission, brings together a large number of research institutions to collect data and carry out research to understand all the impacts of the pandemic, and create predictive models that can be used to optimize intervention strategies and better face possible future health emergencies. One of the main tangible outcomes of this project is the PERISCOPE Atlas: an interactive tool that allows to visualize and analyze COVID-19-related health, economic and sociopolitical data, featuring a WebGIS and several dashboards. This paper describes the first release of the Atlas, listing the data sources used, the main functionalities and the future development.