Miracle-dz/UniFAR-FTUs huggingface dataset:
Circulating Plasma Gelsolin: A Predictor of Favorable Clinical Outcomes in Head and Neck Cancer and Sensitive Biomarker for Early Disease Diagnosis Combined with Soluble Fas Ligand

Head and neck cancer (HNC) accounts for more than 330,000 cancer deaths annually worldwide. Despite late diagnosis being a major factor contributing to HNC mortality, no satisfactory biomarkers exist for early disease detection. Cytoplasmic gelsolin (cGSN) was discovered to predict disease progression in HNC and other malignancies, and circulating plasma gelsolin (pGSN) levels are significantly correlated with infectious and inflammatory disease prognoses. Here, the plasma levels of five candidate biomarkers (circulating pGSN, squamous cell carcinoma antigen, cytokeratin 19 fragment, soluble Fas, and soluble Fas ligand (sFasL)) in 202 patients with HNC and 45 healthy controls were measured using enzyme-linked immunosorbent assay or Millipore cancer multiplex assay. The results demonstrated that circulating pGSN levels were significantly lower in patients with HNC than in healthy controls. Moreover, circulating pGSN outperformed other candidate biomarkers as an independent diagnostic biomarker of HNC in both sensitivity (82.7%) and specificity (95.6%). Receiver operating characteristic curves indicated that combined pGSN and sFasL levels further augmented this sensitivity (90.6%) for early disease detection. Moreover, higher pGSN levels predicted improved prognosis at both 5-year overall survival and progression-free survival. In conclusion, circulating pGSN could be an independent predictor of favorable clinical outcomes and a novel biomarker for the early HNC detection in combination with sFasL.
A Multidisciplinary Delphi Consensus Study of Communicative Participation in Young Children With Language Disorders.

Purpose Our aim was to develop consensus on the definition and operationalization of communicative participation (CP) in 2- to 8-year-old children with language disorders (LDs). A clear definition and operationalization can facilitate the discussion about children's communication problems in daily life between parents and professionals. Method In an online Delphi study, anonymized thoughts and opinions were collected on the definition and operationalization of CP in young children with LD. The 47 Delphi panel members were Dutch parents, young adults with LDs, teachers and assistants, speech-language pathologists, clinical linguists, and clinical researchers. Thematic content analysis was used to develop a concept definition and items operationalizing CP. The Delphi panel rated the suitability of concept definitions using a 7-point Likert scale. Concept definitions were revised with feedback from the Delphi panel until consensus was achieved. The Delphi panel rated items on how well they operationalize CP, using the same Likert scale. Results The majority (79%) of the Delphi panel indicated that the essence of CP was captured by the definition: "CP is understanding and being understood in a social context, by applying verbal and non-verbal communication skills. " In addition, 33 behavioral items were developed. Conclusion This study resulted in strong consensus on the definition of CP between Dutch parents and professionals. Items were developed that can inform speech-language pathologists on the type of questions to ask a child's parents or teacher when discussing CP. Further research is needed on how the items can best be used in clinical practice.
Self-force correction to geodetic spin precession in Kerr spacetime

We present an expression for the gravitational self-force correction to the geodetic spin precession of a spinning compact object with small, but non-negligible mass in a bound, equatorial orbit around a Kerr black hole. We consider only conservative back-reaction effects due to the mass of the compact object ($m_1$) thus neglecting the effects of its spin $s_1$ on its motion, i.e, we impose $s_1 \ll G m_1^2/c$ and $m_1 \ll m_2$, where $m_2$ is the mass parameter of the background Kerr spacetime. We encapsulate the correction to the spin precession in $\psi$, the ratio of the accumulated spin-precession angle to the total azimuthal angle over one radial orbit in the equatorial plane. Our formulation considers the gauge-invariant $\ord(m_1)$ part of the correction to $\psi$, denoted by $\Delta\psi$, and is a generalization of the results of [Class. Quan. Grav. , 34, 084001 (2017)] to Kerr spacetime. Additionally, we compute the zero-eccentricity limit of $\Delta\psi$ and show that this quantity differs from the circular-orbit $\Delta\psi^\text{circ}$ by a gauge-invariant quantity containing the gravitational self-force correction to general relativistic periapsis advance in Kerr spacetime. Our result for $\Delta\psi$ is expressed in a manner that readily accommodates numerical/analytical self-force computations, e.g., in radiation gauge, and paves the way for the computation of a new eccentric-orbit Kerr gauge invariant beyond the generalized redshift.
Collecting large datasets of rotational electron diffraction with ParallEM and SerialEM

A semi-automated protocol has been developed for rotational data collection of electron diffraction patterns by combined use of SerialEM and ParallEM, where SerialEM is used for positioning of sample crystals and ParallEM for rotational data collection. ParallEM calls standard camera control software through an AutoIt script, which adapts to software operational changes and to new GUI programs guiding other cameras. Development included periodic flashing and pausing of data collection during overnight or day-long recording with a cold field-emission beam. The protocol proved to be efficient and accurate in data collection of large-scale rotational series from two JEOL electron microscopes, a general-purpose JEM-2100 and a high-end CRYO ARM 300. Efficiency resulted from simpler steps and task specialization. It is possible to collect 12–20 rotational series from ∼ −68º to ∼ 68º at a rotation speed of 1º /s in one hour without human supervision.
Assessment of Volatiles and Polyphenol Content, Physicochemical Parameters and Antioxidant Activity in Beers with Dotted Hawthorn (Crataegus punctata)

Beer with the addition of dotted hawthorn (Crataegus punctata) fruit and juice was prepared and analysed. The content of carbohydrates, glycerol and ethanol in beers was determined by high-performance liquid chromatography (HPLC). Analysis of the total content of polyphenols was also performed using the Folin-Ciocalteu method, as well as determining antioxidant capacity by DPPH• and ABTS+• assay, and the ability to reduce iron ions by FRAP assay. Content of volatile compounds was analysed by means of solid-phase microextraction and gas chromatography coupled with mass spectroscopy. Beers with addition of hawthorn, both juice and fruit, had higher antioxidative potential and higher polyphenols concentration compared to control beer. The content of polyphenols in beers was in the range 200.5–410.0 mg GAE/L, and the antioxidant activity was in the range of 0.936–2.04 mmol TE/L (ABTS+• assay), 0.352–2.175 mmol TE/L (DPPH• assay) and 0.512–1.35 mmol TE/L (FRAP assay). A sensory evaluation of beers was also carried out. Beer with hawthorn fruit addition obtained the best scores in sensory analysis for criteria such as aroma, taste and overall quality. This beer had the highest content of volatile compounds (287.9 µg/100 mL of beer), while the control beer had lowest concentrations (35.9 µg/100 mL of beer).
Phylogenetic and functional underdispersion in Neotropical phyllostomid bat communities

Habitat conversion creates a mosaic of land cover types, which affect the spatial distribution, diversity, and abundance of resources. We used abundance, functional, and phylogenetic information to determine if Neotropical bat communities exhibited phylogenetic or functional overdispersion or underdispersion in response to habitat conversion. Overdispersion suggests the operation of intraclade competition, niche partitioning, limiting similarity, or character displacement, whereas underdispersion indicates the operation of interclade competition, abiotic filtering, or biotic filtering. We expected (1) biotic filtering in landscapes with extensive forest loss to result in underdispersion; (2) niche partitioning in heterogeneous landscapes with intermediate forest loss to result in overdispersion; and (3) intraclade competition during times of low resource abundance (i.e., dry season) to increase, resulting in overdispersion. Most bat communities exhibited phylogenetic or functional underdispersion; none exhibited overdispersion. Expectations were not met: underdispersion did not increase with forest loss, heterogeneous landscapes did not induce overdispersion, and no evidence supported the contention that intraclade competition changed with season. Empirical responses were season‐specific, likely because resource availability may affect relationships between forest cover and underdispersion and between biodiversity and underdispersion. During the dry season, only high diversity sites exhibited underdispersion (i.e., functional or phylogenetic redundancy), whereas underdispersion occurred in low, intermediate, or high diversity communities during the wet season; we suggest that this difference likely arises due to changes in resource abundance. Communities with high diversity and redundancy occupied heterogeneous sites during the dry season, but communities with high redundancy were restricted to large forest reserves during the wet season.
Sensor-to-Segment Calibration Methodologies for Lower-Body Kinematic Analysis with Inertial Sensors: A Systematic Review

Kinematic analysis is indispensable to understanding and characterizing human locomotion. Thanks to the development of inertial sensors based on microelectronics systems, human kinematic analysis in an ecological environment is made possible. An important issue in human kinematic analyses with inertial sensors is the necessity of defining the orientation of the inertial sensor coordinate system relative to its underlying segment coordinate system, which is referred to sensor-to-segment calibration. Over the last decade, we have seen an increase of proposals for this purpose. The aim of this review is to highlight the different proposals made for lower-body segments. Three different databases were screened: PubMed, Science Direct and IEEE Xplore. One reviewer performed the selection of the different studies and data extraction. Fifty-five studies were included. Four different types of calibration method could be identified in the articles: the manual, static, functional, and anatomical methods. The mathematical approach to obtain the segment axis and the calibration evaluation were extracted from the selected articles. Given the number of propositions and the diversity of references used to evaluate the methods, it is difficult today to form a conclusion about the most suitable. To conclude, comparative studies are required to validate calibration methods in different circumstances.
Preferential Trade Agreements and Global Sourcing

We study how a preferential trade agreement (PTA) affects international sourcing decisions, aggregate productivity and welfare under incomplete contracting and endogenous matching. Contract incompleteness implies underinvestment. That inefficiency is mitigated by a PTA, because the agreement allows the parties in a vertical chain to internalize a larger return from the investment. This raises aggregate productivity. On the other hand, the agreement yields sourcing diversion. More efficient suppliers tilt the tradeoff toward the (potentially) beneficial relationship-strengthening effect; a high external tariff tips it toward harmful sourcing diversion. A PTA also affects the structure of vertical chains in the economy. As tariff preferences attract too many matches to the bloc, the average productivity of the industry tends to fall. When the agreement incorporates "deep integration" provisions, it boosts trade flows, but not necessarily welfare. Rather, "deep integration" improves upon "shallow integration" if and only if the original investment inefficiencies are serious enough. On the whole, we offer a new framework to study the benefits and costs from preferential liberalization in the context of global sourcing.
Are Children from Divorced Single-Parent Families Disadvantaged? New Evidence from the China Family Panel Studies

Abstract Since the beginning of the twenty-first century, divorced single parenthood has become more prevalent in China. Nevertheless, divorced single parenthood and its impact on child outcomes have not been studied as much in China as in the West. Most studies in Western societies have reported that divorce and single parenthood are associated with disadvantaged child outcomes. This has been attributed in part to the prevalence of divorce among parents with low socioeconomic status and decreased child monitoring when one parent is absent. In China, however, there are several buffering mechanisms that may reduce the negative impact of divorce on children. Using data from four waves of the China Family Panel Studies, this study examines the effects of divorce and single parenthood on children’s academic performance and subjective wellbeing. The results show that children living with divorced single mothers performed as well as children from intact families, whereas children living with divorced single fathers and stepparents were disadvantaged in academic performance and subjective wellbeing. Frequent quarrels between parents in intact families also had a negative impact on child outcomes.
THE ROLE OF THE VG1 ZEBRAFISH ORTHOLOG GDF3 IN NODAL-DEPENDENT MESENDODERM FORMATION AND LEFT-RIGHT PATTERNING

iii List of Figures. vii Acknowledgements. viii Chapter 1: Introduction. 1 1.1 Introductory statement. 2 1.2 Nodal in mesendoderm formation. 2 1.3 Nodal in left-right patterning. 5 1.4 Gdf3/Vg1 in embryonic patterning. 7 Chapter 2: The role of maternal gdf3 during germ layer specification. 12 2.
Multiple Contracting in Insurance Markets

We study insurance markets in which privately informed consumers can purchase coverage from several insurers. Under adverse selection, multiple contracting severely restricts feasible trades. Indeed, only one budget-balanced allocation is implementable by an entry-proof tariff, and each layer of coverage must be fairly priced given the consumer types who purchase it. This allocation is the unique equilibrium outcome of a game in which cross-subsidies between contracts are prohibited. Equilibrium contracts exhibit quantity discounts and negative correlation between risk and coverage. Public intervention should target insurers’ strategic behavior, while consumers can be left free to choose their preferred amount of coverage.
Far plasma wake of Titan from the RPWS observations: A case study

The Titan's plasma wake has been investigated using observations from the Radio and Plasma Wave Science (RPWS) instrument onboard the Cassini spacecraft during one Titan flyby on December 26, 2005. The Langmuir Probe and the wideband receiver suggest a strong asymmetry of the plasma wake, which is displaced from the ideal wake. Two distinct structures are identified inbound and outbound of the flyby with significantly different electron number densities (ne). The maximum electron number density reached 14 cm−3 on the Saturn side, connected to the sunlit ionosphere, while on the opposite side of Saturn observations indicate a density smaller than 2 cm−3. Other derived parameters of the Langmuir probe analysis suggest also a difference in plasma composition between the two structures, where heavy and light ions dominate the Saturn and anti‐Saturn side respectively. The total ion outflow is estimated at 2–7 × 1025 ions/s assuming a cylindrical geometry for the plasma wake.
Major earthquake at the Pleistocene-Holocene transition in Lake Vättern, southern Sweden

Lake Vattern, Sweden, is within a graben that formed through rifting along the boundary between two Precambrian terrains. Geophysical mapping and geological coring show that substantial tectonic movements along the Lake Vattern graben occurred at the very onset of the Holocene. This is evident from deformation structures in the soft sediment accumulated on the lake floor. Our interpretation of these structures suggests as much as 13 m of vertical tectonic displacements along sections of a >80-km-long fault system. If these large displacements are from one tectonic event, Lake Vattern must have had an earthquake with seismic moment magnitudes to 7.5. In addition, our geophysical mapping shows large landslides along sections of the steep lake shores. Pollen analysis of sediment infillings of some of the most prominent sediment deformation structures places this major seismic event at the Younger Dryas-Preboreal transition, ca. 11.5 ka. We suggest that this event is mainly related to the rapid release of ice-sheet load following the deglaciation. This paleoseismic event in Lake Vattern ranks among the larger known intraplate tectonic events in Scandinavia and attests to the significance of glacio-isostatic unloading.
Commentary: psychoanalysis and psychoanalytic therapies (Jeremy D. Safran, American psychological association, 2012)

Clinical or methodological significance of this article: The present book review has a primarily clinical significance, as it is aimed at commenting and promoting a book that introduces and provides guidance towards understanding psychoanalysis and its psychotherapeutic practice. The book’s clinical and didactic nature is manifest by a complementary video that illustrates the application of a specific theory through a real-life case discussed by the author. The reviewer thoughtfully comments on the contributions, highlights and controversial issues presented in the book.
Cornea Analysis of Factors Associated With the Tear Film Lipid Layer Thickness in Normal Eyes and Patients With Dry Eye Syndrome

Citation: Jung JW, Park SY, Kim JS, Kim EK, Seo KY, Kim T-I. Analysis of factors associated with the tear film lipid layer thickness in normal eyes and patients with dry eye syndrome. Invest Ophthalmol Vis Sci. 2016;57:4076–4083. DOI:10.1167/iovs.16-19251 PURPOSE. To determine the effects of clinical variables, including age, sex, history of refractive or cataract surgery, contact lens use, and ocular surface and meibomian gland parameters on the lipid layer thickness (LLT) in normal subjects and patients with dry eye syndrome (DES).
Thermal dynamics at surfaces

The present paper describes what happens at the surface of a crystal as its temperature steadily increases from zero Kelvin close to the bulk melting temperature. We treat thermal motion, such as the diffusion of individual adatoms establishing mass transport, the formation of adatom or vacancy gases coexisting with islands or steps of the condensed phase, surface phonons and the anharmonicity of the surface potential being markedly different from the one in bulk, as well as thermally induced reconstructions, surface roughening, and finally surface melting, which usually well precedes bulk melting. The paper intends to give an overview with references to the original and review literature.
Financial Constraints and the Value of Cash During and After the Financial Crisis of 2008

This thesis studies the impacts of the financial crisis of 2008 and its aftermath to the marginal value of cash for shareholders in the United States. The tests are conducted with the methodology of Faulkender & Wang (2006) with a total sample of 2679 firms and 25720 firm-years. This study adds to earlier literature by showing that the shareholders of an average firm value extra cash higher during the financial crisis due to more restricted access to debt, lower expectations of future income, increase in short-term debt and decrease in new equity issuance. After the crisis, the value of cash has since decreased below the levels of the pre-crisis period. I also find, that the cash is valued lower for constrained firms during the crisis due to lower investment activity and relatively higher debt and interest expenses. Unconstrained firms do not face similar changes and their cash is valued higher during the crisis period. The findings imply that these results for constrained and unconstrained firms are only temporary due to the crisis, as after the crisis the differences in value of cash between constrained and unconstrained firms present similar results with the earlier literature. Bachelor’s Thesis Lauri Karjalainen Aalto University School of Business Finance Fall 2018 Author Lauri Karjalainen Title of thesis Financial Constraints and the Value of Cash During and After the Financial Crisis of 2008 Degree B.Sc. Degree programme Finance Thesis advisor(s) Bünyamin Önal Year of approval yyyy Number of pages 29 Language English
The Opening of the Field: Thoughts on the Poetics of Psychoanalytic Treatment

This article compares poetic communication with psychoanalytic communication, especially in terms of the way subjective states are communicated and intersubjective conjunction is achieved. Four areas of poetics are discussed: metaphor, in which objects are charged with subjective meaning; image, which has the narrative quality of presenting acts of perception; sound and rhythm, which communicate affect; and form, which gives the psychoanalytic encounter a collaboratively achieved sense of shape and inevitability. Metaphors transfer objects from the natural world into the field of the poem. They exist in transitional space between subject and object. In analysis, they exist in the intersubjective field between patient and therapist, and act as a conduit for understanding and connection. The twin tendencies of patients to retreat from metaphoric understanding into the concrete and of therapists to reify metaphors into absolute truths are seen as retreats from poetry and intersubjective relatedness. Images, whether they are retrieved from memory, from dreams, or from daily perception, have an immediacy that directly connects the therapist to the patient's experience. They offer a direct point of entry to the patient's narrative. The sound and rhythm of patient's speech convey their affect states in the same way they carry the feeling in a poem. Long vowels convey yearning, short vowels convey urgency, and hard consonants convey limits or inevitability. The dialog of sound and rhythm between therapist and patient is analogous to the attachment-enabling nonverbal dialog between infant and caregiver.
Appendix — Not Intended for Publication A Sampling Properties of the ORIV Estimator

There are several textbooks and survey articles that present methods for inference in linear and non-linear models with measurement error, a topic that is also addressed in almost any statistics and econometrics textbook. A common approach to this problem exploits repeated measurements (or replicates) to characterize the severity of measurement error. After estimating these distributional features of the measurement error, researchers can compute correction factors that dis-attenuate sample estimates. Our ORIV method provides a simple unifying method for consistent estimation that integrates all information available for relating two variables to one another. To our knowledge, it is the first to do so. In this technical appendix, we present a standard suite of results establishing consistency and asymptotic normality, along with consistent standard errors, for the ORIV estimator. These properties are proved using textbook-standard arguments presented primarily for completeness.