Miracle-dz/UniFAR-FTUs huggingface dataset:
IMMUNOLOGICAL CRITERIA OF THE COURSE OF NON-HODGKIN’S LYMPHOMAS

A deep against the background of activation of which an and the of the main IgG, IgA, IgM The highest content of IgG and IgA was revealed in the groups of patients with It has been established that one of the most important humoral markers of immunity is the circulating immune complexes (CICs). It has been established that one of the most important biological functions of immunoglobulins is antigen binding and the formation of CIC. A high level of CIC in may be due not only to the activation of the immune but also to the suppression of the mechanisms of their elimination. Therefore, based on the results obtained, with NHL there is a pronounced imbalance of humoral immunity. CIC of large and small sizes are also increased, however, the highest increase in CIC was observed in groups of patients before chemotherapy with virus-bearing. An increase in the main immunoglobulins indicates the presence of humoral imbalance, and an increase in the CIC indicates the presence of intoxication of the body either due to the decay of the tumor cells and infected cells themselves, which almost always indicates the progression of the pathological process.
Attack Maze for Network Vulnerability Analysis Computing the Maximum Possible Incursion and Intuitive Metrics

— Even a well administered computer network will be vulnerable to attacks. There have been many proposals in the literature to address the problem of Network-Vulnerability Analysis. One approach is to generate an attack graph (a logical graph representation of all possible sequences of vulnerabilities) using some formal model. Attack graphs suffer from scalability issues as the size of the network or the number of services and vulnerabilities increase. This paper presents a new approach that treats the network as a maze , which the attacker has to solve. We then use the classical way to solve mazes in computer games – remembering where we have been by dropping things at each node. We present a graph-based algorithm to solve this maze and compute the Maximum Possible Incursion (MPI) for a given set of attackers or compromises. The developed simple breadth-first algorithm provides performance improvements over previous approaches (less than a minute to analyze a network with over 10,000 nodes). We also present a methodology to capture mission dependency, which represents how a mission relies on the underlying network. Finally, we compute an extensible set of security metrics that identify the current network status in multiple dimensions (e.g. Confidentiality, Integrity, and Availability). We also discuss future work to enumerate the specific attack paths that could be used to generate corrective recommendations.
An Easy and Efficient Grammar Generator for Understanding Spoken Languages A Novel approach to develop a Spoken Language Understanding Grammar for Inflective Languages

— In a Spoken Dialog System, the Spoken Language Understanding component is able to recognize words that were previously included in its grammar. The development of a grammar is a very time-consuming and error-prone process, especially for the inflectional languages, because the developer must manually include all possible inflected forms of a word. As a consequence, the grammar definition files are long and hard to manage. This paper describes a solution for creating a semi-automatic Spoken Language grammar using a morphological generator.
Prognostic Value of the Insertion/ Deletion polymorphism of Angiotensin I Converting Enzyme gene in type 2 diabetic subjects: results from the DIABHYCAR, DIAB2NEPHROGENE & SURDIAGENE studies.

Samy HADJADJ, MD, PhD (1,2), Frédéric FUMERON, PhD (3,4), Ronan ROUSSEL, MD, PhD (3,4,5), Pierre-Jean SAULNIER, MD (6), Yves GALLOIS, PharmaD, PhD (7), Amos ANKOTCHE, MD (5), Florence TRAVERT, MD (8), Charbel ABI KHALIL, MD (3,4,5), Aurélie MIOT (1), François ALHENC-GELAS, MD, PhD (9), Michel LIEVRE, MD, PhD (10), Michel MARRE, MD, PhD (3,4,5), on behalf of the DIABHYCAR, DIAB2NEPHROGENE & SURDIAGENE study groups.
LOCAL WELLPOSEDNESS FOR THE CRITICAL NONLINEAR

For p ≥ 2, we prove local wellposedness for the nonlinear Schr¨odinger equation ( i∂ t + ∆) u = ±| u | p u on T 3 with initial data in H s c ( T 3 ), where T 3 is a rectangular irrational 3-torus and s c = 32 − 2 p is the scaling-critical regularity. This extends work of earlier authors on the local Cauchy theory for NLS on T 3 with power nonlinearities where p is an even integer.
New Width Parameters of Graphs

Abstract The main focus of this thesis is on using the divide and conquer technique toeciently solve graph problems that are in general intractable. We work inthe eld of parameterized algorithms, using width parameters of graphs thatindicate the complexity inherent in the structure of the input graph. We usethe notion of branch decompositions of a set function introduced by Robert-son and Seymour to de ne three new graph parameters, boolean-width, max-imum matching-width (MM-width) and maximum induced matching-width(MIM-width). We compare these new graph width parameters to existinggraph parameters by de ning partial orders of width parameters. We focuson tree-width, branch-width, clique-width, module-width and rank-width,and include a Hasse diagram of these orders containing 32 graph parameters.We use the size of a maximum matching in a bipartite graph as a setfunction to de ne MM-width and show that MM-width never di ers by morethan a multiplicative factor 3 from tree-width. The main reason for introduc-ing MM-width is that it simpli es the comparison between tree-width andparameters de ned via branch decomposition of a set function.We use the logarithm of the number of maximal independent sets in a bi-partite graph as set function to de ne boolean-width. We show that boolean-width of a graph class is bounded if and only if rank-width is bounded, andshow that the boolean-width of a graph can be as low as the logarithm of therank-width of the graph. Given a decomposition of boolean-width k, we de-sign FPT algorithms parameterized by k, for a large class of graph problems,whose runtime has a single exponential dependency in the boolean-width,i.e. O
Do profitable banks with a solid capital base have a higher ratio of capital buffer? : Reviewing the impact of regulation, the previous financial crisis and banks own incentives of having excess capital.

The financial crisis starting in mid-2007 is still affecting us, and with increased regulation banks and institutions are supposed to get more solvent and the industry to become more stable. The Basel Committee is working towards more unified regulation across countries, but the question is how the increased regulation is affecting banks financials. Do profitable banks with a solid capital base have a higher ratio of capital buffer? Looking at banks in 16 OECD countries during the period 1993-2009, with country-level panel-data displayed in two simultaneous equation estimations illustrating how profit and capital buffer has changed during these years, and the relation between them. To get an understanding of how the crisis affected these variables the regressions are also done for a pre-crisis period of 1993-2006. Internal funding variables and other economic control variables are explanatory variables and results show the internal funding variables have a large effect on profit and for capital buffer profit have the largest impact. Results imply that profitable banks with a solid capital base do have a higher ratio of capital buffer. The results coincide with the franchise value theory which is applied in the paper.
Berberine, Quercetin and O-Coumaric Acid Phytochemicals Ameliorate the Impact of Experimentally Fed High-Fat/High-Sucrose Diet on Pancreas Β-Cells and Glycemic Control Indices

Background: The worldwide growing pandemic of diabetes necessitates much attention to combat the pathogenetic metabolic syndrome. Aim: The present study aimed at investigating the possible ameliorative effect of oral administration of each of Quercetin (Q), O-Coumaric Acid (CA) and Berberine (BB) natural phytochemicals on pancreatic β-cells and glycemic control impact of High Fats/High Sucrose (HFS) diet in Wistar Albino rats. Methods: Fifty young adult animals (100-120 g body weight) were classified into 5 groups; normal diet-fed control group, HFS diet-fed control group, and, 3 HFS diet-fed treatment groups. After 6 weeks of induction, each of HFS diet-fed treatment groups was treated with Q, CA, or BB for a further 6 weeks. Light and EM histopathological changes, morphometric pancreatic islet mass and glycemic control indices (fasting serum glucose and insulin levels and insulin resistance) were evaluated. Results: Rats fed HFS diet suffered from hyperglycemia and hyperinsulinemia that both caused insulin resistance accompanied with increase in islet mass and degeneration of β-cell granules. Treatment with Q, CA or BB reversed the biochemical and histological changes, albeit, BB was the most efficient. Conclusion: The investigated phytochemicals restored glycemic control and insulin sensitivity in rats fed HFS diet with BB as the strongest β-cells pancreato-protective. (IR)
Their Important Role in Wound HealingSupports Human Neutrophils in Skin Lesions The Transcriptional Activation Program of

To investigate the cellular fate and function of polymorphonuclear neutrophilic granulocytes (PMNs) attracted to skin wounds, we used a human skin-wounding model and microarray technology to deﬁne differentially expressed genes in PMNs from peripheral blood, and PMNs that had transmigrated to skin lesions. After migration to skin lesions, PMNs demonstrated a signiﬁcant transcriptional response including genes from several different functional categories. The up-regulation of anti-apoptotic genes concomitant with the down-regulation of proapoptotic genes suggested a transient anti-apoptotic priming of PMNs. Among the up-regulated genes were cytokines and chemokines critical for chemotaxis of macrophages, T cells, and PMNs, and for the modulation of their inﬂammatory responses. PMNs in skin lesions down-regulated receptors mediating chemotaxis and anti-microbial activity, but up-regulated other receptors involved in inﬂammatory responses. These ﬁndings indicate a change of responsiveness to chemotactic and immunoregulatory mediators once PMNs have migrated to skin lesions and have been activated. Other effects of the up-regulated cytokines/chemokines/enzymes were critical for wound healing. These included the breakdown of ﬁbrin clots and degradation of extracellular matrix, the promotion of angiogenesis, the migration and proliferation of keratinocytes and ﬁbroblasts, the adhesion of keratinocytes to the dermal layer, and ﬁnally, the induction of anti-microbial gene expression in keratinocytes. Notably, the up-regulation of genes, which activate lysosomal proteases, indicate a priming of skin lesion-PMNs for degradation of phagocytosed material. These ﬁndings demonstrate that migration of PMNs to skin lesions induces a transcriptional activation program, which regulates cellular fate and function, and promotes wound healing. The Journal of Immunology,
The Sun–Earth Connection

According to one of New Haven Public Schools science curriculum standards, students must recognize fundamental concepts about changes in the environment and the effects of the environmental change on the earth and its resources. In third grade, students study the solar system. This unit will touch upon the science standards and the third grade unit. The principal objective of this unit is to have creative, critical thinkers who are able to understand the relationship between the Earth and the Sun. This unit will provide elementary school teachers with hands-on activities that will integrate science, mathematics, language arts, and art.
Inducible NO Synthase Expression during and Alterations in Neutrophilic Inflammation Novel Cellular Targets of AhR Underlie

The underlying reasons for variable clinical outcomes from respiratory viral infections remain uncertain. Several studies suggest that environmental factors contribute to this variation, but limited knowledge of cellular and molecular targets of these agents hampers our ability to quantify or modify their contribution to disease and improve public health. The aryl hydrocarbon receptor (AhR) is an environment-sensing transcription factor that binds many anthropogenic and natural chemicals. The immunomodu-latory properties of AhR ligands are best characterized with extensive studies of changes in CD4 + T cell responses. Yet, AhR modulates other aspects of immune function. We previously showed that during inﬂuenza virus infection, AhR activation modulates neutrophil accumulation in the lung, and this contributes to increased mortality in mice. Enhanced levels of inducible NO synthase (iNOS) in infected lungs are observed during the same time frame as AhR-mediated increased pulmonary neutrophilia. In this study, we evaluated whether these two consequences of AhR activation are causally linked. Reciprocal inhibition of AhR-mediated elevations in iNOS and pulmonary neutrophilia reveal that although they are contemporaneous, they are not causally related. We show using Cre/ loxP technology that elevated iNOS levels and neutrophil number in the infected lung result from separate, AhR-dependent signaling in endothelial and respiratory epithelial cells, respectively. Studies using mutant mice further reveal that AhR-mediated alterations in these innate responses to infection require a functional nuclear localization signal and DNA binding domain. Thus, gene targets of AhR in non-hematopoietic cells are important new considerations for understanding AhR-mediated changes in innate anti-viral immunity. The Journal of Immunology , 2013, 190: 000–000.
A visual reporter system for VIGS in tomato fruit based on anthocyanin accumulation.

Virus Induced Gene Silencing (VIGS) is a powerful ). However, the irregular distribution of the effects of VIGS hampers the identification and quantification of non-visual phenotypes. To overcome this limitation a visually traceable VIGS system was developed for fruit, comprising two elements: ( i ) a transgenic tomato line (Del/Ros1) expressing Antirrhinum maju s Delila and Rosea1 transcription factors under the control of fruit-specific E8 promoter, showing a purple-fruited, anthocyanin-rich phenotype and ( ii ) a modified Tobacco Rattle Virus (TRV) VIGS vector incorporating partial Rosea1 and Delila sequences, which was shown to restore the red-fruited phenotype upon agroinjection in Del/Ros1 plants. Dissection of silenced areas for subsequent chemometric analysis successfully identified the relevant metabolites underlying gene function for three tomato genes, pds, TomloxC and SlODO1 , used for proof of concept: The C-6 aldehydes derived from lipid 13-hydroperoxidation were found to be the volatile compounds most severely affected by TomloxC silencing, whereas geranial and 6-methyl-5-hepten-2-one were identified as the volatiles most severely reduced by phytoene desaturase ( pds ) silencing in ripening fruits. In a third example, silencing of SlODO1, a tomato homologue of the ODORANT1 gene encoding a MYB transcription factor, which regulates benzenoid metabolism in petunia flowers, resulted in a sharp accumulation of benzaldehyde in tomato fruit. Together, these results indicate that fruit-VIGS, enhanced by anthocyanin monitoring, can be a powerful tool for reverse genetics in the study of the metabolic networks operating during fruit ripening. SA, Hill JH (2009) Development and use of an efficient DNA-based viral gene silencing vector for soybean. Mol Plant Microbe Interact 22: 123-131
Children with Dyslexia Have Altered Cross-Modal Processing Linked to Binocular Fusion. A Pilot Study

Introduction: The cause of dyslexia, a reading disability characterized by dif ﬁ culties with accurate and/or ﬂ uent word recognition and by poor spelling and decoding abilities, is unknown. A considerable body of evidence shows that dyslexics have phonological disorders. Other studies support a theory of altered cross-modal processing with the existence of a pan-sensory temporal processing de ﬁ cit associated with dyslexia. Learning to read ultimately relies on the formation of automatic multisensory representations of sounds and their written representation while eyes ﬁ x a word or move along a text. We therefore studied the effect of brief sounds on vision with a modi ﬁ cation of binocular fusion at the same time (using the Maddox Rod test). Methods: To check if the effect of sound on vision is speci ﬁ c, we ﬁ rst tested with sounds and then replaced them with proprioceptive stimulation on 8 muscular sites. We tested two groups of children composed respectively of 14 dyslexic children and 10 controls. Results: The results show transient visual scotoma (VS) produced by sensory stimulations associated with the manipulation of oculomotor balance, the effect being drastically higher in the dyslexic group. The spatial distribution of the VS is stochastic. The effect is not speci ﬁ c for sounds but exists also with proprioceptive stimulations. Discussion: Although there was a very signi ﬁ cant difference between the two groups, we were not able to correlate the (VS) occurrence with the dyslexic ’ s reading performance. One possibility to con ﬁ rm the link between VS and reading impairment would be to ﬁ nd a speci ﬁ c treatment reducing the occurrence of the VS and to check its effect on dyslexia.
The Performance of MCUSUM Control Charts when the Multivariate Normality Assumption Is Violated

A multivariate cumulative sum (MCUSUM) control chart is one type of multivariate control chart for monitoring the mean vector. A multivariate normal distribution is an important assumption that is used to describe a behavior of a set of quality characteristics of interest. This research explores the sensitivity of ARLs and SDRLs when the MVN assumption is incorrect. ARLs and SDRLs for data from multivariate t, uniform, beta, and lognormal distributions are estimated and compared to ARLs and SDRLs under the MVN assumption. The ratios of SDRL/ARL are also computed to consider a relationship between ARL and SDRL. ______________________________
PneumoniaRequired for Lung Protection during Leukemia Inhibitory Factor Signaling Is

Lung infections represent a tremendous disease burden and a leading cause of acute lung injury. STAT3 signaling is essential for controlling lung injury during pneumonia. We previously identiﬁed LIF as a prominent STAT3-activating cytokine expressed in the airspaces of pneumonic lungs, but its physiological signiﬁcance in this setting has never been explored. To do so, Escherichia coli was intratracheally instilled into C57BL/6 mice in the presence of neutralizing anti-LIF IgG or control IgG. Anti-LIF completely eliminated lung LIF detection and markedly exacerbated lung injury compared with control mice as evidenced by airspace albumin content, lung liquid accumulation, and histological analysis. Although lung bacteriology was equivalent between groups, bacteremia was more prevalent with anti-LIF treatment, suggestive of compromised barrier function rather than impaired antibacterial defense as the cause of dissemination. Inﬂammatory cytokine expression was also exaggerated in anti-LIF–treated lungs, albeit after injury had ensued. Interestingly, alveolar neutrophil recruitment was modestly but signiﬁcantly reduced compared with control mice despite elevated cytokine levels, indicating that inﬂammatory injury was not a consequence of excessive neutrophilic alveolitis. Lastly, the lung transcriptome was dramatically remodeled during pneumonia, but far more so following LIF neutralization, with gene changes implicating cell death and epithelial homeostasis among other processes relevant to tissue injury. From these ﬁndings, we conclude that endogenous LIF facilitates tissue protection during pneumonia. The LIF–STAT3 axis is identiﬁed in this study as a critical determinant of lung injury with clinical implications for pneumonia patients. The Journal of Immunology , 2012, 188: 000–000.
MULTIPLE SENSOR BASED CHANNEL ESTIMATION AND BEAMFORMING MECHANISM FOR WIRELESS POWERED SENSOR NETWORK

-The wireless power transmission methods are build with Radio Frequency (RF) based energy transmission techniques. The multi antenna based power transmission scheme is used to charge the sensor nodes. An adaptive beamforming scheme dynamically focuses the microwave beam towards a sensor node. The receive power based channel estimation and energy beamforming algorithm is applied for the power charging process. The sensor energy storage is managed with an adaptive duty cycle control algorithm. Proportional Integral Derivative (PID) controller is used in the adaptive duty cycle control algorithm. The energy harvesting scheme is build to charge only one sensor node using the multi antenna based radio frequency power transmission mechanism. The wireless power transmission scheme is constructed to charge one or multiple sensor nodes at a time. The channel estimation algorithm is enhanced to support energy beamforming on multiple sensor nodes. Multiple node energy distribution is managed with beam splitting and time sharing algorithm. The energy scheduling algorithm is employed to handle the energy neutrality. The large scale transmit antenna array model is build to improve the end to end energy transfer efficiency.
MRF Stereo Matching with Statistical Estimation of Parameters

I am submitting herewith a dissertation written by Mohammad Shafikul Huq entitled “MRF Stereo Matching with Statistical Estimation of Parameters. ” I have examined the final electronic copy of this dissertation for form and content and recommend that it be accepted in partial fulfillment of the requirements for the degree of Doctor of Philosophy, with a major in Electrical Engineering. Mongi A. Abidi , Major Professor We have read this dissertation and recommend its acceptance:
University of Garden and landscape-scale correlates of moths of differing conservation status

Moths are abundant and ubiquitous in vegetated terrestrial environments and are pollinators, important herbivores of wild plants, and food for birds, bats and rodents. In recent years, many once abundant and widespread species have shown sharp declines that have been cited by some as indicative of a widespread insect biodiversity crisis. Likely causes of these declines include agricultural intensification, light pollution, climate change, and urbanization; however, the real underlying cause(s) is still open to conjecture. We used data collected from the citizen science Garden Moth Scheme (GMS) to explore the spatial association between the abundance of 195 widespread British species of moth, and garden habitat and landscape features, to see if spatial habitat and landscape associations varied for species of differing conservation status. We found that associations with habitat and landscape composition were species-specific, but that there were consistent trends in species richness and total moth abundance. Gardens with more diverse and extensive microhabitats were associated with higher species richness and moth abundance; gardens near to the coast were associated with higher richness and moth abundance; and gardens in more urbanized locations were associated with lower species richness and moth abundance. The same trends were also found for species classified as increasing, declining and vulnerable under IUCN (World Conservation Union) criteria. However, vulnerable species were more strongly negatively affected by urbanization than increasing species. Two hypotheses are proposed to explain this observation: (1) that the underlying factors causing declines in vulnerable species (e.g., possibilities include fragmentation, habitat deterioration, agrochemical pollution) across Britain are the same in urban areas, but that these deleterious effects are more intense in urban areas; and/or (2) that urban areas can act as ecological traps for some vulnerable species of moth, the light drawing them in from the surrounding landscape into sub-optimal urban habitats.