Miracle-dz/UniFAR-FTUs huggingface dataset:
Membrane-Coated Biomimetic Nanoparticles: A State-of-the-Art Multifunctional Weapon for Tumor Immunotherapy

The advent of immunotherapy, which improves the immune system’s ability to attack and eliminate tumors, has brought new hope for tumor treatment. However, immunotherapy regimens have seen satisfactory results in only some patients. The development of nanotechnology has remarkably improved the effectiveness of tumor immunotherapy, but its application is limited by its passive immune clearance, poor biocompatibility, systemic immunotoxicity, etc. Therefore, membrane-coated biomimetic nanoparticles have been developed by functional, targeting, and biocompatible cell membrane coating technology. Membrane-coated nanoparticles have the advantages of homologous targeting, prolonged circulation, and the avoidance of immune responses, thus remarkably improving the therapeutic efficacy of tumor immunotherapy. Herein, this review explores the recent advances and future perspectives of cell membrane-coated nanoparticles for tumor immunotherapy.
Planetary Boundary Layer Simulation Using TASS

Boundary conditions to an existing large-eddy simulation model have been changed in order to simulate turbulence in the atmospheric boundary layer. Several options are now available, including the use of a surface energy balance. In addition, we compare convective boundary layer simulations with the Wangara and Minnesota field experiments as well as with other model results. We find excellent agreement of modelled mean profiles of wind and temperature with observations and good agreement for velocity variances. Neutral boundary simulation results are compared with theory and with previously used models. Agreement with theory is reasonable, while agreement with previous models is excellent.
Comparison between High-Power Short-Duration and Conventional Ablation Strategy in Atrial Fibrillation: An Updated Meta-Analysis

High-power short-duration (HPSD) setting during radiofrequency ablation has become an attempt to improve atrial fibrillation (AF) treatment outcomes. This study ought to compare the efficacy, safety, and effectiveness between HPSD and conventional settings. PubMed, Embase, and Cochrane Library were searched. Studies that compared HPSD and conventional radiofrequency ablation settings in AF patients were included while studies performed additional ablations on nonpulmonary vein targets without clear recording were excluded. Data were pooled with random-effect model. Efficacy endpoints include first-pass pulmonary vein isolation (PVI), acute pulmonary vein (PV) reconnection, free from AF, and free from atrial tachycardia (AT) during follow-up. Safety endpoints include esophagus injury rate and major complication rate. Effectiveness endpoints include complete PVI rate, total procedure time, PVI time, and PVI radiofrequency ablation (PVI RF) time. We included 22 studies with 3867 atrial fibrillation patients in total (2393 patients received HPSD radiofrequency ablation). Perioperatively, the HPSD group showed a higher first-pass PVI rate (risk ratio, RR = 1.10, P = 0.0001) and less acute PV reconnection rate (RR = 0.56, P = 0.0004) than the conventional group. During follow-up, free from AF (RR = 1.11, P = 0.16) or AT (RR = 1.06, P = 0.24) rate did not differ between HPSD and conventional groups 6-month postsurgery. However, the HPSD group showed both higher free from AF (RR = 1.17, P = 0.0003) and AT (RR = 1.11, P < 0.0001) rate than the conventional group 12-month postsurgery. The esophagus injury (RR = 0.99, P = 0.98) and major complications (RR = 0.76, P = 0.70) rates did not differ between the two groups. The HPSD group took shorter total procedure time (MD = −33.71 95% CI: -43.10 to -24.33, P < 0.00001), PVI time (MD = −21.60 95% CI: -25.00 to -18.21, P < 0.00001), and PVI RF time (MD = −13.72, 95% CI: -14.45 to -13.00, P < 0.00001) than conventional groups while complete procedure rate did not differ between two groups (RR = 1.00, P = 0.93). HPSD setting during AF radiofrequency ablation has better effectiveness, efficacy, and similar safety compared with the conventional setting.
A Directly Compressible Pregelatinised Sago Starch: A New Excipient in the Pharmaceutical Tablet Formulations

An excipient intended for direct compression in pharmaceutical tableting must show important features of flowability and compactibility. This study investigated pregelatinised sago starch as an excipient for direct compression tablets. Pregelatinised sago starch was prepared and characterised. Its powder bulk properties and performance in the tablet formulations with paracetamol as a model drug were compared against two commercial, directly compressible excipients, namely Avicel® PH 101 and Spress® B820. The results showed that pregelatinisation did not affect the chemical structure of sago starch, but its degree of crystallinity reduced, and X-ray diffraction pattern changed from C-type to A-type. Powder bulk properties of pregelatinised sago starch and Spress® B820 were comparable, exhibiting better flowability but lower compactibility than Avicel® PH 101. In the formulation of paracetamol tablets, pregelatinised sago starch and Spress® B820 performed equally well, followed by Avicel® PH 101 as indicated in Formulations 3, 2 and 1, respectively.
Tailored Extracellular Vesicles: Novel Tool for Tissue Regeneration

Extracellular vesicles (EVs) play an essential part in multiple pathophysiological processes including tissue injury and regeneration because of their inherent characteristics of small size, low immunogenicity and toxicity, and capability of carrying a variety of bioactive molecules and mediating intercellular communication. Nevertheless, accumulating studies have shown that the application of EVs faces many challenges such as insufficient therapeutic efficacy, a lack of targeting capability, low yield, and rapid clearance from the body. It is known that EVs can be engineered, modified, and designed to encapsulate therapeutic cargos like proteins, peptides, nucleic acids, and drugs to improve their therapeutic efficacy. Targeted peptides, antibodies, aptamers, magnetic nanoparticles, and proteins are introduced to modify various cell-derived EVs for increasing targeting ability. In addition, extracellular vesicle mimetics (EMs) and self-assembly EV-mimicking nanocomplex are applied to improve production and simplify EV purification process. The combination of EVs with biomaterials like hydrogel, and scaffolds dressing endows EVs with long-term therapeutic efficacy and synergistically enhanced regenerative outcome. Thus, we will summarize recent developments of EV modification strategies for more extraordinary regenerative effect in various tissue injury repair. Subsequently, opportunities and challenges of promoting the clinical application of engineered EVs will be discussed.
LETTER TO THE EDITOR: Experimental observation of Raman chirped adiabatic rapid passage

In this letter, we present the first experimental results of climbing a vibrational ladder by Raman chirped adiabatic rapid passage. We obtain the bandwidth necessary for this experiment by utilizing pulses from a unique dual-wavelength high-intensity laser. The vibrationally excited molecules are field ionized by an intense 180 fs laser pulse, enabling us to probe the extent of the vibrational excitation of the symmetric stretch based on an enhanced ionization calculation.
Amicable pairs and aliquot cycles on average

Silverman and Stange defined the notion of an aliquot cycle of length L for a fixed elliptic curve E/ℚ, and conjectured an order of magnitude for the function that counts such aliquot cycles. We show that the conjectured upper bound holds for the number of aliquot cycles on average over the family of all elliptic curves with short bounds on the size of the parameters in the family.
Mentalizing the modern world

A theoretical paper in which the theory of mentalizing and epistemic trust are applied to thinking about the relationship between social systems and individual subjective experiences, and how this relationship may be shaped by developmental history, such as attachment experiences, exposure to childhood adversity, and the experience of being mentalized. We suggest that the experience of being mentalized and openness to epistemic trust may be the mechanism by which individual experiences of psychic distress, perception of self-agency and perceptions of others, are both influenced by and shape wider social phenomena and social change. We consider the impact of social inequalities and the breakdown of political legitimacy on mentalizing, epistemic trust and psychopathology, and argue that optimal individual outcomes cannot always be achieved without adaptation of the wider social environment.
Gunboat Diplomacy in Natuna Waters 2010-2020 : Indonesia’s Deterrence in South China Sea Conflict

SCS conflict comprises a substantial threat to Indonesia as China's nine-dash line overlaps with Indonesia's Exclusive Economic Zone EEZ in Natuna waters. The spillover effect of the conflict was exposed through China's incursions in Natuna waters from 2010 to 2020. China regards it as having the right to carry out activities in several areas of Natuna waters that are considered part of Indonesia's maritime territorial violations. Indonesia deploys the capabilities of its naval forces in Natuna waters in response to China's incursions, which could be regarded as gunboat diplomacy. This study aimed to reveal the efficacy of Indonesia's gunboat diplomacy to deter China's incursions in Natuna Waters. The qualitative method will analyze official documents and relevant literature to answer the study's objective. Employing gunboat diplomacy and deterrence as the conceptual framework, this study discerns that Indonesian naval forces became the forefront instrument of gunboat diplomacy in deterring China's assertiveness in the SCS dispute, which led to the incursions over Indonesia's maritime territory in Natuna. This study discovered that through the concept of gunboat diplomacy, Indonesia leveraged warships as a purposeful and expressive force to deter Chinese vessels ’ activities in Natuna waters. By using warships as the media of diplomacy, Indonesia cracked down on China's incursions at a particular point of the occasion. However, as Indonesia's deterrence means, gunboat diplomacy has not thoroughly delivered a deterrent effect to China since Chinese vessels' activities still recurred in Natuna waters.
Parallelization of Cellular Automata for Surface Reactions

We present a parallel implementation of cellular automata to simulate chemical reactions on surfaces. The scaling of the computer time with the number of processors for this parallel implementation is quite close to the ideal T/P, where T is the computer time used for one single processor and P the number of processors. Two examples are presented to test the algorithm, the simple A+B->0 model and a realistic model for CO oxidation on Pt(110). By using large parallel simulations, it is possible to derive scaling laws which allow us to extrapolate to even larger system sizes and faster diffusion coefficients allowing us to make direct comparisons with experiments.
Hybrid Brain–Computer Interface Spellers: A Walkthrough Recent Advances in Signal Processing Methods and Challenges

Abstract Hybrid brain computer interfaces (hBCIs) have emerged as a possible path to integrated brain-computer interaction in current history. hBCI, is a device formed by the amalgamation of control signal and bio-signal combination of control signal with one or more bio-signals that enhances system performance and usability. Assistive technology, spelling, and gaming are some of the primary areas where hBCI can be used. Among these, hBCI spellers are the popular application that has opened up a slew of new possibilities of communication for paralyzed individuals. The goal of this review is to provide prospect on current state of hBCI spellers covering types of hBCI, signal processing methods and evaluation with emphasis on feature extraction techniques and classification methods used by these studies. The authors anticipate that this analysis will serve as a foundation for ongoing studies on hBCI spellers.
Resonance Phenomena in Goupillaud-type Media

Abstract : The discrete resonance frequency spectrum is derived for an m-layered Goupillaud-type elastic medium subjected to a discrete, time-harmonic forcing function at one end, with the other end fixed. Analytical stress solutions are derived from a global system of recursion relationships using z-transform methods, where the determinant of the resulting global system matrix |Am| in the z-space is a palindromic polynomial with real coefficients. The zeros of the palindromic polynomial are distinct and are proven to lie on the unit circle for m between 1 and 5. An important result is the physical interpretation that all positive angles, coterminal with the angles corresponding to the zeros of |Am| on the unit circle, represent the resonance frequency spectrum for the discrete model. The resonance frequency results are then extended to analytically describe the natural frequency spectrum of a free-fixed m-layered Goupillaud-type medium. The predicted natural frequency spectrum is validated by independently solving a simplified version of the frequency equation involving a transformation of the spatial variable. The natural frequency spectrum is shown to depend only on the layer impedance ratios and is inversely proportional to the equal wave travel time for each layer. A sequence of resonance frequencies for the discrete model is found, which is universal for all multilayered designs with an odd number of layers, and independent of any design parameters.
Etude de quelques methodes de resolution de problemes lineaires de grande taille sur multiprocesseur

Cette these etudie la vectorisation et la parallelisation d'algorithmes d'algebre lineaire. Dans la premiere partie nous etudions et comparons plusieurs methodes de resolution d'un probleme symetrique generalise de valeurs propres sur une architecture multiprocesseur a memoire partagee: multisections pour matrices profil, tridiagonalisation pour matrices bande, methode de lanczos par blocs pour matrices creuses, non structurees. Dans la deuxieme partie nous presentons une nouvelle methode iterative de sous-espace par blocs pour resoudre un systeme lineaire symetrique defini positif et a plusieurs seconds membres. Puis nous comparons ses performances sur un multiprocesseur a memoire partagee a d'autres methodes: la methode gmres dont nous proposons une implantation par blocs et la methode du gradient conjugue preconditionne. Dans ces deux parties les matrices sont des matrices creuses de grande taille pour lesquelles nous envisageons et comparons divers rangements avec, comme calculateur de reference, le cray2. Enfin dans une troisieme partie nous etudions l'influence de la repartition des donnees dans l'implantation sur une architecture distribuee de deux algorithmes pour matrices pleines: gram-schmidt modifie et decomposition en valeurs singulieres. Les tests sont alors realises sur l'hypercube ipsc2
Relationships between age, diet, and stress-related hormones and reproduction in American marten (Martes americana)

American marten (Martes americana) in Interior Alaska are at the northwestern limit of their North American range. To investigate factors that may be associated with reproduction we determined the cementum age and the presence or absence of blastocysts in 118 female martens for 3 years (2012, 2014, and 2016) in two regions. For each marten we collected fur samples and measured steroid hormone concentrations (cortisol, testosterone, and progesterone) and stable isotopes (δ15N and δ13C values, a proxy for diet). These parameters reflect the diet and endocrine activity between June and October when fur is grown. We also collected two claws from a subset of 39 female marten from one region in 2012 and 2014. Progesterone concentrations were measured in one whole claw and from a second claw divided into proximal (recent growth) and distal sections. Differences in the probability of blastocysts being present were associated with geographic region and sample year suggesting that reproduction in female marten varies on a fine scale. We found the that presence of blastocysts was positively associated with marten age and δ15N values in fur but negatively associated with fur cortisol concentrations. These findings suggest that the likelihood a female marten will reproduce in a given year is influenced, in part, by the proportion of protein in their diet and stressors encountered during late summer and fall, months before active gestation begins.
The Replacement of Ground Corn with Sugar Beet in the Diet of Pasture-Fed Lactating Dairy Cows and Its Effect on Productive Performance and Rumen Metabolism

Simple Summary Cereal grains have increased in cost, and therefore dairy farmers try to find alternatives to provide energy in the rumen. Sugar beet roots have high energy content and may be a sound alternative to replace ground corn partially or totally in the diet of dairy cows. Thus, the aim of this study was to evaluate the replacement of ground corn with fresh sugar beet on the milk production responses, rumen metabolism, and profitability of pasture fed dairy cows. Although cows supplemented with sugar beet roots had reduced dry matter intake and milk production compared with control cows, fat percentage was increased, and therefore, there were no differences in energy corrected milk yield (FPCM) among the treatments. Moreover, feeding costs were reduced, and thus, the margin over feed costs was increased for sugar beets. In addition, the replacement of ground corn by sugar beets reduced urinary N excretion, and thus, it may contribute to the reduction in N2O emission from dairy systems. Using sugar beet roots as an energy supplement can be a suitable alternative to ground corn in pasture-fed lactating dairy cows, increasing the sustainability of dairy systems. Abstract (1) Background: Sugars have a potential to provide great amounts of fermentable energy in the rumen. Feeding fresh sugar beet (SB) to dairy cattle to replace a portion of the grain in the ration has not received sufficient attention. This study determined dry matter intake (DMI), feeding behavior, rumen fermentation and milk production responses when replacing corn grain with increasing levels of SB in pasture-fed lactating dairy cow diets. (2) Methods: A total of 12 early-lactation cows were used in a replicated (n = 4) 3 × 3 Latin square design. The control diet consisted of 21 kg dry matter (DM) composed of 6.3 kg DM green chopped perennial ryegrass, 7 kg DM grass silage, 2 kg DM of concentrate, 1 kg DM soybean meal and 4.5 kg DM of ground corn. The other treatments replaced 50% or 100% of the ground corn with SB roots. (3) Results: The replacement of ground corn with sugar beet reduced DMI and milk yield (p < 0.05), but it increased milk fat concentration (p = 0.045), reduced feeding costs and increased margin over feed costs (p < 0.01). Urinary nitrogen was linearly reduced with SB supplementation (p = 0.026). (4) Conclusions: Using SB roots as energetic supplement can be a suitable alternative to ground corn in pasture-fed lactating dairy cows.
3D Pose from Three Corresponding Points Under Weak-Perspective Projection

Model-based object recognition commonly involves using a minimal set of matched model and image points to compute the pose of a model in image coordinates. This paper discusses how to compute the pose of a model from three corresponding points under ``weak-perspective'''' projection. A new solution to the problem is proposed which, like previous solutions, involves solving a biquadratic equation. Here the biquadratic is motivated geometrically, and its solutions are interpreted graphically. The final equations take a new form, which lead to a simple expression for the image position of any unmatched model point.
Multispectral Image Super Resolution with Auto-Encoder Model and Fusion Technique

Obtaining High Resolution(HR) Multispectral Images which are not readily available is one of the more critical objectives in remote sensing applications as these images can be used for various agricultural applications and previously various other methods like pansharpening have been introduced. This paper proposes a novel convolutional auto-encoder for training the multispectral images obtained from Sentinel -2A Satellite and then pass the degraded multispectral image to obtain the reconstructed Multispectral Image which is spectrally enhanced and then fuse the image obtained from reconstruction with the original degraded image to obtain a spatial HR Multispectral Image. This fusion is done using various state of the art methods like Principal Component Analysis(PCA), Discrete Wavelet Transform Level-l(DWT) and Stationary Wavelet Transform Level-l(SWT) and the performance metrics.
ARTICULATING THE CCM APPROACH AND LESSON STUDY: a promising teacher professional development towards inclusive education

Quality provision of inclusion is directly impacted by the extent to which inclusive teaching practices are provided in inclusive educational settings. Besides exploring the contemporary concept of inclusion, this paper addresses the international research literature on Lesson Study (LS) for inclusive settings and investigates the Constructionist, Contextualized and Meaningful (CCM) approach by Schlünzen et al. (2020) as a possible fit to create enhanced conditions for inclusive education in tandem with LS. Findings showed that international experiential studies using LS for improving inclusion shared similar nature with the CCM approach regarding the collaboration amongst teachers for effective professional learning and the centrality of the students' voices to improve and transform teaching practices towards inclusion. Finally, the study suggests that the articulated use of LS and the CCM approach might ignite more effective inclusive teaching practices whilst providing an education that promotes all learning, and meets the needs of all students in inclusive educational settings. This study also indicates further avenues for empirical research to deepen the understanding of how the LS movement and the CCM approach integrated to teaching and learning can impact education in different cultures.
Psychological Support for Mothers Victims of Perinatal Death by Caregivers: Case of the Regional Hospital Center (RHC) of Yamoussoukro

The loss of a baby during the perinatal period leads to a real grieving process for mothers since they establish an attachment bond with their baby before birth. If relatives and environment bereaved underestimate this particular type of bereavement and its potential impact, this should not be the case for nursing staff. And yet, in African maternities, there are very few psychological support for mothers who are victims of perinatal death. Perinatal bereavement deserves to be analyzed in all its complexity. The aim of this study is to show the importance of psychological support for mothers who are victims of perinatal death in the prevention of negative impact on the mental health of mothers. Quantitative and qualitative data are collected on a sample of 55 selected mothers through a purposive non-probability sampling strategy. Quantitative data are processed with SPSS 20 software. Text processing as well as tables and graphs were produced with Word 2016 and Excel 2016 software. The results indicate on the one hand that the psychological support provided by the nursing staff reduces the harmful effects of perinatal bereavement on mothers and on the other hand, the need for the establishment of a support protocol for couples in health facilities. Keywords: perinatal death, bereavement, mothers, psychological support.