Miracle-dz/UniFAR-FTUs huggingface dataset:
The anteriorization of tooth position underlies the atavism of tooth morphology: Insights into the morphogenesis of mammalian molars

The evolution and development of complex molars as a key innovation in mammals have long been of interest yet remain poorly understood. With reference to century‐old theories and modern findings, we focused on the teeth of pinnipeds (Carnivora) and cetaceans (Cetartiodactyla), which are morphologically simple compared with those of other mammals, and thus can be considered a reversal toward the ancestral state of nonmammalian synapsids. By reconstructing the evolutionary history of tooth complexity for the phylogenies of Carnivora and Cetartiodactyla, we established that a secondary evolution of simple teeth from more complex molars has occurred independently multiple times. Our phylogenetic comparative analyses showed that a simplification in tooth morphology was correlated with a more anterior dentition position relative to the component bones of the upper jaw in both Carnivora and Cetartiodactyla. These results suggest that the anterior shift of tooth position relative to the morphogenetic fields present in the jaw contributed to the evolutionary simplification in molar morphology. Our findings provide insights into the developmental basis of complex mammalian dentition.
Coherent methods in the X-ray sciences

X-ray sources are developing rapidly and their coherent output is growing correspondingly. The increased coherent flux from modern X-ray sources is being matched with an associated development in experimental methods. This article reviews the literature describing the ideas that utilize the increased brilliance from modern X-ray sources. It explores how ideas in coherent X-ray science are leading to developments in other areas, and vice versa. The article describes measurements of coherence properties and uses this discussion as a base from which to describe partially coherent diffraction and X-ray phase-contrast imaging, with applications in materials science, engineering and medicine. Coherent diffraction imaging methods are reviewed along with associated experiments in materials science. Proposals for experiments to be performed with the new X-ray free-electron lasers are briefly discussed. The literature on X-ray photon-correlation spectroscopy is described and the features it has in common with other coherent X-ray methods are identified. Many of the ideas used in the coherent X-ray literature have their origins in the optical and electron communities and these connections are explored. A review of the areas in which ideas from coherent X-ray methods are contributing to methods for the neutron, electron and optical communities is presented.
Low relative hand grip strength is associated with a higher risk for diabetes and impaired fasting glucose among the Korean population

Objective This study investigated the association between relative hand grip strength (HGS) and glycemic status, such as impaired fasting glucose (IFG) and diabetes, using data from the Korea National Health and Nutrition Examination Survey (KNHANES). Methods We performed a cross-sectional study using the data from the KNHANES of 27,894 individuals from 2014 to 2019. Relative HGS was defined as the absolute HGS divided by body mass index and divided into quartiles in men and women. Odds ratios (OR) for diabetes and IFG were calculated using multivariate logistic regression analysis. All analyses were stratified by sex, and subgroup analysis was age-stratified. Results The lowest relative HGS quartile had a significant increase in the risk for diabetes (men: OR 2.72, 95% confidence interval [CI] 2.12–3.50; women: OR 3.38, 95% CI 2.70–4.24) and IFG (men: OR 1.35, 95% CI 1.15–1.59; women: OR 1.60, 95% CI 1.40–1.84). The ORs for diabetes and IFG according to the decreasing quartiles of relative HGS gradually increased in both sexes (P for trend <0.001). ORs and 95% CI of the lowest relative HGS quartile for diabetes were higher in the younger age group than that of the older age group (men: 4.47 and 2.80–7.14 for young adults; 2.41 and 1.37–4.25 for older adults; women: 5.91 and 3.06–9.38 for young adults; 1.47 and 0.92–2.33 for older adults). ORs and 95% CI for IFG was similar with the trend of ORs for diabetes (men: 1.80 and 1.43–2.26 for young adults; 1.17 and 0.75–1.84 for older adults; women: 2.20 and 1.77–2.72 for young adults; 1.33 and 0.86–2.07 for older adults). Conclusion Lower relative HGS was associated with a higher risk of not only diabetes but also IFG in both sexes. These trends were stronger in younger adults than in older adults.
Strange Horizons: Understanding Causal Barriers Beyond General Relativity

This thesis explores two avenues into understanding the physics of black holes and horizons beyond general relativity, via analogue models and Lorentz violating theories. Analogue spacetimes have wildly different dynamics to general relativity; this allows the possibility of non-Killing horizons in stationary solutions. In the case of non-Killing horizons different definitions of surface gravity are truly different quantities. This also has application to modified theories of gravity, where there is no reason to expect all horizons to be Killing horizons. In Lorentz violating theories, the situation becomes even stranger, as Killing horizons are at best low energy barriers, but for superluminal dispersion relations a true causal barrier, the universal horizon, may be present. We investigate the nature of these universal horizons via a ray tracing study, and delve into what happens near both the universal and Killing horizons. From this study we determine the surface gravity of universal horizons by the peeling properties of rays near the horizon and discuss whether, and at what temperature these horizons radiate. Finally, we combine our investigations of universal horizons and analogue spacetimes, and ask why we have not seen a universal horizon in studies of analogue gravity.
RNA‐seq profiling reveals different pathways between remodeled vessels and myocardium in hypertrophic cardiomyopathy

Coronary microvascular dysfunction (CMD) is a key pathophysiological feature of hypertrophic cardiomyopathy (HCM), contributing to myocardial ischemia and representing a critical determinant of patients' adverse outcome. The molecular mechanisms underlying the morphological and functional changes of CMD are still unknown. Aim of this study was to obtain insights on the molecular pathways associated with microvessel remodeling in HCM.
Expression of miR-223 to predict outcomes after transcatheter aortic valve implantation

Background Transcatheter aortic valve implantation (TAVI) is an established treatment for aortic stenosis (AS) in patients at increased surgical risk. Up to 29% of patients annually experience major adverse cardiac and cerebrovascular events (MACCE) after TAVI. MicroRNAs (miRNA) are currently widely investigated as novel cardiovascular biomarkers. The aim of this study was to determine the influence of TAVI on the expressions of selected miRNAs associated with platelet function (miR-125a-5p, miR-125b and miR-223), and evaluate the predictive value of these miRNAs for MACCE in 65 patients undergoing TAVI. Methods Venous blood samples for miRNA expression analysis were collected 1 day before TAVI and at hospital discharge. The expression of miR-223, miR-125a-5p, miR-125b was evaluated in platelet-depleted plasma. Results The expression of miR-223 and miR-125b increased after TAVI, compared to the measurement before (p = 0.020, p = 0.003, respectively). Among 63 patients discharged from the hospital, 18 patients experienced MACCE (29%) during the median 15 months of observation. Baseline low miR-223 expression was a predictor of MACCE in univariate Cox regression analysis (hazard ratio [HR]: 2.71, 95% confidence interval [CI]: 1.04–7.01; p = 0.041). After inclusion of covariates, age, gender (male), New York Heart Association class and diabetes into the multivariate Cox regression model, miR-223 did not reach statistical significance (HR: 2.56, 95% CI: 0.79–8.33; p = 0.118). Conclusions To conclude, miR-223 might improve risk stratification after TAVI. Further studies are required to confirm the clinical applicability of this promising biomarker.
Simulation-Based Education in Physical Therapist Professional Education: A Scoping Review.

OBJECTIVES The purposes of this study were to (1) describe and summarize the use of simulation-based education (SBE) with student physical therapists in the international literature and (2) describe the application and integration of standards of best practice (SOBP) for SBE reported in published physical therapy education research. METHODS Ovid MEDLINE, CINAHL, Web of Science, and ERIC databases were searched. The search included any study published that involved the use of SBE with student physical therapists. Because this was a scoping review, only descriptive statistics were compiled; no methodologic quality assessment was performed. RESULTS This scoping review revealed a significant increase in literature describing SBE with student physical therapists in the past 10 years. Simulation was used to address learning objectives across a variety of content areas and clinical settings. Communication skills were the most common objectives for simulation. Limited use of SOBP, published in 2016, was reported and use of author-generated outcome measures without validation was common. CONCLUSIONS Although there has been an increase in literature reporting the use of SBE with student physical therapists across many practice areas and settings, many articles reported limited use and integration of published SOBP and frequently utilized outcome measures that had not been validated.
High‐resolution multi‐shot diffusion‐weighted MRI combining markerless prospective motion correction and locally low‐rank constrained reconstruction

Subject head motion is a major challenge in DWI, leading to image blurring, signal losses, and biases in the estimated diffusion parameters. Here, we investigate a combined application of prospective motion correction and spatial‐angular locally low‐rank constrained reconstruction to obtain robust, multi‐shot, high‐resolution diffusion‐weighted MRI under substantial motion.
New anatomical insights of the superficial branch of the zygomaticotemporal nerve for treating temporal migraines: An anatomical study

The zygomaticotemporal nerve is known to contribute to temporal migraines; however, its precise anatomy remains unknown. The potential accessory branches of the zygomaticotemporal nerve may be considered a cause of continued temporal migraines after surgical procedures. In this study, we defined the novel superficial branch of the zygomaticotemporal nerve (sZTN) and investigated its anatomical course, distribution, and clinical implications. Twenty‐two hemifaces from 11 fixed Korean cadavers (six males, five females; mean age, 78.3 years) were used in this study. The piercing points of the sZTN through the deep and superficial layers of the deep temporal fascia, and the superficial temporal fascia were defined as P1, P2, and P3, respectively. The distance of each point from the zygomatic tubercle was measured using an image analysis software. The sZTN ascended between the bone and the temporalis after emerging from the zygomaticotemporal foramen. It then pierced the deep temporal fascia without penetrating the temporalis. After then, it pierced the superficial layer of the deep temporal fascia and turned superiorly toward the upper posterior temple. When the sZTN passed through the superficial temporal fascia, it intersected with the superficial temporal artery in every case. The novel findings of the sZTN may help in the treatment of intractable temporal migraines refractory to injection or surgical procedure. Based on our findings, targeting the sZTN may be applied as an alternative treatment strategy for patients who do not show significant improvement with treatment targeted to trigger sites.
The Changing Paradigm of Drug-Resistant Tuberculosis Treatment: Successes, Pitfalls, and Future Perspectives

Drug-resistant tuberculosis (DR-TB) remains a global crisis due to the increasing incidence of drug-resistant forms of the disease, gaps in detection and prevention, models of care, and limited treatment options. The DR-TB treatment landscape has evolved over the last 10 years. SUMMARY Drug-resistant tuberculosis (DR-TB) remains a global crisis due to the increasing incidence of drug-resistant forms of the disease, gaps in detection and prevention, models of care, and limited treatment options. The DR-TB treatment landscape has evolved over the last 10 years. Recent developments include the remarkable activity demonstrated by the newly approved anti-TB drugs bedaquiline and pretomanid against Mycobacterium tuberculosis. Hence, treatment of DR-TB has drastically evolved with the introduction of the short-course regimen for multidrug-resistant TB (MDR-TB), transitioning to injection-free regimens and the approval of the 6-month short regimens for rifampin-resistant TB and MDR-TB. Moreover, numerous clinical trials are under way with the aim to reduce pill burden and shorten the DR-TB treatment duration. While there have been apparent successes in the field, some challenges remain. These include the ongoing inclusion of high-dose isoniazid in DR-TB regimens despite a lack of evidence for its efficacy and the inclusion of ethambutol and pyrazinamide in the standard short regimen despite known high levels of background resistance to both drugs. Furthermore, antimicrobial heteroresistance, extensive cavitary disease and intracavitary gradients, the emergence of bedaquiline resistance, and the lack of biomarkers to monitor DR-TB treatment response remain serious challenges to the sustained successes. In this review, we outline the impact of the new drugs and regimens on patient treatment outcomes, explore evidence underpinning current practices on regimen selection and duration, reflect on the disappointments and pitfalls in the field, and highlight key areas that require continued efforts toward improving treatment approaches and rapid biomarkers for monitoring treatment response.
On the nature of dust clouds in the region towards M81 and NGC3077

There is some controversy on the nature of dust clouds found in direction of the interacting galaxy triplett M81, M82, and NGC3077. Are they associated with the tidal arms seen in HI around those galaxies or are they simply Galactic foreground clouds? Data from the SPIRE instrument onboard HERSCHEL and MIPS onboard of SPITZER are used to derive physical parameters for the dust clouds. These observions are compared to CO clouds previously mapped with the IRAM and the FCRAO radio telescopes.SPIRE and MIPS maps show several dust clouds north of M81 and south of NGC3077. Modelling of the dust emission provides total hydrogen column densities between 1.5 and 5.0 * 10^20 cm^-2. Dust temperatures are between 13 to 17K. No significant difference in the dust emission can be found between individual clouds. It is shown that CO line emission provides the best clues on the origin of those clouds. Most of the clouds seen towards M81 are associated with small-area molecular structures (SAMS), i.e. tiny CO clouds of Galactic origin. The clouds seen towards NGC3077 are partly associated with the tidal arms and are partly in the Galactic foreground associated with SAMS.
Electronic effect‐dependent intramolecular non‐covalent interactions on the activity of 4,4‐dimethylimidazolidin‐2‐one pharmacophore‐based androgen receptor antagonists

Because androgen receptor (AR) signalling is important for the development and progression of prostate cancer (PC), AR antagonists are utilized in clinical practices to treat PC and are referred to as androgen deprivation therapy (ADT). However, continued administration of AR antagonists often results in the development of resistance, known as castration‐resistant prostate cancer (CRPC). Despite castration, it has been demonstrated that AR signalling continues to be fundamental to tumour growth. In this regard, a series of readily synthesizable 4,4‐dimethylimidazolidine‐2‐one pharmacophore‐based AR antagonists (FAR01‐FAR11) were designed and synthesized. Androgen‐dependent LNCaP PC cell line was used to test the AR‐antagonist activity of these compounds in vitro and compared with the U.S. Food and Drug Administration (FDA) approved second‐generation enzalutamide. In our previous work, rigid thiohydantoin pharmacophore in enzalutamide is replaced by the flexible 4,4‐dimethylimidazolidin‐2‐one. In order to improve the flexibility further, one methylene group is introduced between the pharmacophore and one of the aromatic ring. Despite the fact that the amide functional group is a crucial characteristic for building AR antagonists, this class of molecules lacks one. FAR06 has the exact same activity as enzalutamide (IC50: 0.782 μM) with an IC50 value of 0.801 μM among the series of compounds.
Novel roles for Arabidopsis dynamin-related proteins DRP1A and DRP2B in resistance against Botrytis cinerea fungal infection

ABSTRACT Arabidopsis DYNAMIN-RELATED PROTEIN1A (AtDRP1A) and AtDRP2B are large GTPases that function together in endocytosis for effective cytokinesis, cell enlargement and development. A recent study shows that these DRPs contribute to ligand-induced endocytosis of the immune receptor FLAGELLIN SENSING2 (AtFLS2) to modulate flg22-immune signaling, and they are required for immunity against Pseudomonas syringae pv. tomato bacteria. Here, we demonstrate that atdrp1a and atdrp2b single mutants showed increased susceptibility to Botrytis cinerea indicating that AtDRP1A and AtDRP2B are necessary for effective resistance against this necrotrophic fungus. Thus, we expanded our limited understanding of clathrin endocytic accessory proteins in immunity against plant pathogens.
Microbiota- Brain-Gut-Axis Relevance to Parkinson's Disease: Potential Therapeutic Effects of Probiotics.

Parkinson's disease (PD) is the second most common type of neurogenerative disease among middle-aged and older people, characterized by aggregation of alpha-synuclein and dopaminergic neuron loss. The microbiota-gut-brain axis is a dynamic bidirectional communication network and is involved in the pathogenesis of PD. The aggregation of misfolded protein alpha-synuclein is a neuropathological characteristic of PD, originates in the gut and migrates to the central nervous system (CNS) through the vagus nerve and olfactory bulb. The change in the architecture of gut microbiota increases the level short-chain fatty acids (SCFAs) and other metabolites, acting on the neuroendocrine system and modulating the concentrations of gamma-Aminobutyric acid (GABA), serotonin, and other neurotransmitters. It also alters the vagus and intestinal signalling, influencing the brain and behaviour by activating microglia and systemic cytokines. Both experimental and clinical reports indicate the role of intestinal dysbiosis and microbiota host interaction in neurodegeneration. Probiotics are live microorganisms that modify the gut microbiota in the small intestine to avoid neurological diseases. Probiotics have been shown in clinical and preclinical studies to be effective in the treatment of PD by balancing the gut microbiota. In this article, we described the role of gut-microbiota in the pathogenesis of PD. The article aims to explore the mechanistic strategy of gut-brain axis and its relation with motor impairment and the use of probiotics to maintain gut microbial flora and prevent PD-like symptoms.
Estimation and Effects of the mass outflow rate from shock compressed flow around compact objects

Outflows are common in many astrophysical systems which contain black holes and neutron stars. Difference between stellar outflows and outflows from these systems is that the outflows in these systems have to form out of the inflowing material only. The inflowing material can form a hot and dense cloud surrounding the compact object, either because of a centrifugal barrier, or a denser barrier due to pair plasma or pre-heating effects. This barrier behaves like a stellar surface as far as the mass loss is concerned. We estimate the outflow rate from the regions of shock compressed flow. The outflow rate is directly related to the compression ratio of the gas at the shocks. These estimated rates roughly match the rates in real observations as well as those obtained from numerical experiments. In special geometries, where the solid angle of the outflow is higher, the disk evacuation takes place creating quiescence states. Outflows are shown to be important in deciding the spectral states and Quasi Periodic Oscillations (QPO)s of observed X-rays.
THE NARROW X-RAY TAIL AND DOUBLE Hα TAILS OF ESO 137-002 IN A3627

We present the analysis of a deep Chandra observation of a ∼2 L* late-type galaxy, ESO 137-002, in the closest rich cluster A3627. The Chandra data reveal a long (≳40 kpc) and narrow tail with a nearly constant width (∼3 kpc) to the southeast of the galaxy, and a leading edge ∼1.5 kpc from the galaxy center on the upstream side of the tail. The tail is most likely caused by the nearly edge-on stripping of ESO 137-002's interstellar medium (ISM) by ram pressure, compared to the nearly face-on stripping of ESO 137-001 discussed in our previous work. Spectral analysis of individual regions along the tail shows that the gas throughout it has a rather constant temperature, ∼1 keV, very close to the temperature of the tails of ESO 137-001, if the same atomic database is used. The derived gas abundance is low (∼0.2 solar with the single-kT model), an indication of the multiphase nature of the gas in the tail. The mass of the X-ray tail is only a small fraction (<5%) of the initial ISM mass of the galaxy, suggesting that the stripping is most likely at an early stage. However, with any of the single-kT, double-kT, and multi-kT models we tried, the tail is always “over-pressured” relative to the surrounding intracluster medium (ICM), which could be due to the uncertainties in the abundance, thermal versus non-thermal X-ray emission, or magnetic support in the ICM. The Hα data from the Southern Observatory for Astrophysical Research show a ∼21 kpc tail spatially coincident with the X-ray tail, as well as a secondary tail (∼12 kpc long) to the east of the main tail diverging at an angle of ∼23° and starting at a distance of ∼7.5 kpc from the nucleus. At the position of the secondary Hα tail, the X-ray emission is also enhanced at the ∼2σ level. We compare the tails of ESO 137-001 and ESO 137-002, and also compare the tails to simulations. Both the similarities and differences of the tails pose challenges to the simulations. Several implications are briefly discussed.
Constructing Online Spaces Amid a Pandemic: Advocating for Students Through User-Centered Design

With an increase in online learning environments, especially after the onset of the COVID-19 pandemic, this proposed research paper focuses on the need for student-centered design in online spaces as a form of advocacy. The four authors explore the following question that revolves around online spaces: What are the practices through which user-centered design, especially participatory design through cultural, feminist, enviro-materialist, and disability lenses, might be implemented in online, higher education, or other adult-learning courses? This research article addresses the question of how we as educators, students, and technical communicators can advocate for students and their environments while amid a global pandemic.