Miracle-dz/UniFAR-FTUs huggingface dataset:
Smith, Claire M. and Fry, Stephen C. and Gough, Kevin C. and Patel, Alexandra J.F. and Glenn, Sarah and Goldrick, Marie and Roberts, Ian S. and Whitelam, Garry C. and Andrew, Peter W. (2014) Recombinant plants

Bacterial polysaccharides have numerous clinical or industrial uses. Recombinant plants could offer the possibility of producing bacterial polysaccharides on a large scale and free of contaminating bacterial toxins and antigens. We investigated the feasibility of this proposal by cloning and expressing the gene for the type 3 synthase (cps3S) of Streptococcus pneumoniae in Nicotinia tabacum, using the pCambia2301 vector and Agrobacterium tumefaciens-mediated gene transfer. In planta the recombinant synthase polymerised plant-derived UDP-glucose and UDP-glucuronic acid to form type 3 polysaccharide. Expression of the cps3S gene was detected by RT-PCR and production of the pneumococcal polysaccharide was detected in tobacco leaf extracts by double immunodiffusion, Western blotting and high-voltage paper electrophoresis. Because it is used a component of anti-pneumococcal vaccines, the immunogenicity of the plant-derived type 3 polysaccharide was tested. Mice immunised with extracts from recombinant plants were protected from challenge with a lethal dose of pneumococci in a model of pneumonia and the immunised mice had significantly elevated levels of serum anti-pneumococcal polysaccharide antibodies. This study provides the proof of the principle that bacterial polysaccharide can be successfully synthesised in plants and that these recombinant polysaccharides could be used as vaccines to protect against life-threatening infections. Citation: Smith CM, Fry SC, Gough KC, Patel AJF, Glenn S, et al. (2014) Recombinant Plants Provide a New Approach to the Production of Bacterial Polysaccharide for Vaccines. PLoS ONE 9(2): e88144. doi:10.1371/journal.pone. 0088144 Editor: Eliane Namie Miyaji, Instituto Butantan, Brazil Received August 2, 2013; Accepted January 6, 2014; Published February 3, 2014 Copyright: 2014 Smith et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This work was supported by a grant from the Welcome Trust (067697) to PWA, GCW and ISR. SCF thanks the UK Biotechnology and Biological Sciences Research Council for support. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist. * E-mail: pwa@le.ac. uk ¤a Current address: Department of Respiratory Medicine, Portex Unit, University College London, Institute of Child Health, London, United Kingdom ¤b Current address: Department of Biology, University of Leicester, Leicester, Leicestershire, United Kingdom
CFD Simulation Analysis of the Influence of Floor Area Ratio on the Wind Environment in Residential Districts

The floor area ratio (FAR) in residential districts in China has been expanding continuously as a response to the rapid urbanization and increasing demands for buildings. Consequently, the wind environment in residential districts begins to affect the outdoor comfort of residents. Simulation cases of residential buildings with different FARs were presented in this study to disclose the relationship between FAR and the wind environment in residential districts. First, the wind environment characteristics of residential districts with different FARs were established via computer numerical simulation. Second, wind speed ratio (WSR) and air age distribution were calculated at pedestrian height. Finally, the quantitative relationship between outdoor wind environment and FAR in residential districts was concluded. Results demonstrate a negative linear relationship between FAR and the average WSR (AWSR) in outdoor environment but a positive linear relationship between FAR and average air age. The AWSR in residential areas is decreased by 0.18 and the average air of age is increased by 53.38 s when FAR is increased from 0.63 to 2.32. In other words, increasing FAR in residential areas can decrease the AWSR but increase the average air age, thereby influencing the outdoor comfort of residents. This study provides references to improving wind environment and planning layout in residential districts with high FARs.
The birth of clinical body plethysmography: it was a good week

The Journal of Clinical Investigation http://www.jci. org Volume 114 Number 8 October 2004 1043 expeditions. Sometimes the best we can do for imaginative investigators is to leave them alone so that one thing can lead to another. Making it possible for physician-scientists to examine the mysteries of human physiology and disease in their own style may lead them into blind alleys, but sometimes to breathtaking new vistas. I believe this is as true now as it was in 1956, and I thank Vince Dole and the JCI for reminding me. Address correspondence to: Jules Hirsch, Laboratory of Human Behavior & Metabolism, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA. Phone: (212) 327-8426; Fax: (212) 3277150; E-mail: hirsch@mail.rockefeller. edu.
Analysis of Security Situation in Warri, Nigeria

: This study attempts to investigate whether there could be food insecurity incidence in an ‘’oil city’’ of Warri, Nigeria. The paper also examines the determinants of food insecurity among the households studied. The socio-economic characteristics of 260 households were collected by means of a structured questionnaire. A food insecurity index was constructed and was used to assess household food insecurity incidence. The results obtained were analysed by means of tables and percentages and found that on the average the incidence of food insecurity is high in the study area, implying that the benefits of oil and gas activities in Warri do not actually benefit all in the communities studied Also, a logit model was specified and tested to determine the factors that affect food insecurity in the study area. The results of the two approaches used in this study reveal that the age of household heads, sex of household heads, the type of occupation of household heads and dependency ratio all exacerbate food insecurity in the study area. The level of educational attainment of household heads, the nature of occupation of household heads and income of house heads tend to reduce the probability of households being food insecure. The study recommends food aid and food subsidy to the vulnerable in the area. It also recommends expanded educational facilities to enable inhabitants attain higher levels of education.
Towards efficient consistency enforcement for global constraints in weighted constraint satisfaction

Powerful consistency techniques, such as AC* and FDAC*, have been developed for Weighted Constraint Satisfaction Problems (WCSPs) to reduce the space in solution search, but are restricted to only unary and binary constraints. On the other hand, van Hoeve et al. developed efficient graph-based algorithms for handling soft constraints as classical constraint optimization problems. We prove that naively incorporating van Hoeve's method into the WCSP framework can enforce a strong form of O-Inverse Consistency, which can prune infeasible values and deduce good lower bound estimates. We further show how Van Hoeve's method can be modified so as to handle cost projection and extension to maintain the stronger AC* and FDAC* generalized for non-binary constraints. Using the soft allDifferent constraint as a testbed, preliminary results demonstrate that our proposal gives improvements up to an order of magnitude both in terms of time and pruning.
PRBM_A_199762 619..627

Pichita Teeravisutkul Vasunun Chumchua Pichai Saengcharnchai Thawatchai Leelahanaj 1Department of Psychiatry and Neurology, Phramongkutklao Hospital, Bangkok, Thailand; 2National Institute for Child and Family Development, Mahidol University, Nakhon Pathom, Thailand; 3Department of Psychology and Neurology, Phramongkutklao College of Medicine, Bangkok, Thailand Background and objective: Stress is an environmental cue, which may lead to increased alcohol craving, and vulnerability to relapse. Heart rate variability (HRV) biofeedback, a supplement standard for inpatient rehabilitation, has been applied for treatment and has been shown to effectively reduce craving and anxiety, increase HRV, and improve vasomotor function, among patients who have alcohol dependence problems. Therefore, the purpose of this study was to investigate the impact of HRV biofeedback and the Phramongkutklao model (PMK model) as an intensive inpatient rehabilitation program concerning stress and craving reduction of inpatients with alcohol use disorder. The findings could benefit treatment design to increase the effectiveness regarding stress and craving reduction among patients with alcohol use disorder and may also reduce rehabilitation costs. Methods: We conducted this study as a randomized controlled intervention trial, whichwas also performed single blinded. In all, 35 patients with alcohol use disorder were recruited and randomly assigned in two groups. Patients in the intervention group (n=17) were treated under the PMKmodel and underwent 16 sessions of the HRV biofeedback program, which included 30 minute long sessions, 4 days per week, for 4 weeks continuously. Patients in the control group (n=18) received PMK model treatment only. Participants were asked to complete a Stress Test (ST-5) and the Penn Alcohol-Craving Scale at baseline, after completing treatment, and at one month afterward (follow-up). Results: The study showed decreased stress and craving in the intervention group immediately after treatment and at one-month follow-up, whereas the control group had reduced stress and craving only immediately after treatment. Furthermore, we found a significant effect concerning stress and craving between baseline and at one-month follow-up that showed the intervention group exhibited higher difference of scores than the control group. Conclusion: The study results showed that applying HRV biofeedback may be considered beneficial for standard rehabilitation inpatients to reduce stress and craving for patients with alcohol use disorder.
Humanizing Transit Data: Connecting Customer Experience Statistics to Individuals’ Unique Transit Stories

Transit agencies often collect valuable information about their customers, through opinion and behavior surveys that assess travel experience and customer needs. The results of these questionnaires can be used to gain a representative snapshot of the behavior and opinions of a transit agency’s customer base. These assessments are often based on large sample sizes and are therefore useful for understanding broad trends related to users’ overall travel experience. However, these large-scale analyses generally do not capture the important and rich nuances that individuals experience while in a transit station, or on-board a train, conventional bus, streetcar, light rail, subway, or a paratransit vehicle. The purpose of this paper is to demonstrate how transit agencies can gain a better understanding of paratransit customers’ experiences during their interactions with paratransit and conventional transit services. Using data from the Toronto Transit Commissions’ paratransit division and the results of in-person customer interviews, a five-step mixed-method approach for mapping paratransit customers’ travel experiences is developed. Specifically, the aggregate analyses of customers’ experiences and opinions which are derived from agency-wide customer satisfaction surveys are combined with the information obtained through in-person discussions. Four example customer journey maps (CJMs) are presented, and findings demonstrate that by using CJMs, transit agencies can gain a broad understanding of their customer base while also understanding the emotions, needs, desires, and stories of individual transit users.
M.R.—Health Effects of Written Emotional Disclosure in Adolescents with Asthma: A Randomized Controlled Trial

doi:10.1093/jpepsy/jsj080 Advance Access publication September 14, 2005 Journal of Pediatric Psychology vol. 31 no. 6 © The Author 2005. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org Commentary: Warner, L.J., Lumley, M.A., Casey, R.J., Pierantoni, W. , Salazar, R. , Zoratt, E.M. , Enberg, R. , and Simon, M.R. —Health Effects of Written Emotional Disclosure in Adolescents with Asthma: A Randomized Controlled Trial
An Adaptive Neuro-Fuzzy Inference Model to Predict Punching Shear Strength of Flat Concrete Slabs

An adaptive neuro-fuzzy inference system (ANFIS)-based model was developed to predict the punching shear strength of flat concrete slabs without shear reinforcement. The model was developed using a database collected from 207 experiments available in the existing literature. Five key input parameters were used to build the model, which were slab effective depth, concrete strength, reinforcement ratio, yield tensile strength of reinforcement, and width of square loaded area. The output parameter of the model was punching shear strength. The results from the adaptive neural fuzzy inference model were compared to those from the simplified punching shear equations of ACI, BS-8110, Model Code 2010, Euro-Code 2, and also experimental results. The root mean square error (RMSE) and the correlation coefficient (R) were used as evaluation criteria. Parametric studies were presented using ANFIS to assess the effect of each input parameter on the punching shear strength and to compare ANFIS results to those from the equations proposed in commonly used codes. The results showed that the ANFIS model is simple and provided the most accurate predictions of the punching shear strength of two-way flat concrete slabs without shear reinforcement.
Minimally Invasive Radical Nephrectomy with Inferior Vena Cava Thrombectomy: Is it here to Stay?

superior vena cava, bypass was started. Cavotomy is performed in two points: a lower abdominal cavotomy through renal vein ostium and an upper thoracic cavotomy through right atrium. Tumor thrombus is transected and divided in two parts: the upper part is excised through the atrium and the lower part through abdominal cavotomy, assessing the complete evacuation with endoscopic examination of IVC and transesophageal ultrasonography. the experience with first 9 patients with level III thrombus treated with robot-assisted approach. Surgical technique reproduces quite similar the open approach; it starts with IVC dissection and control below the thrombus. Then, inter-aorto-caval dissection proceeds cephalad through retrohepatic IVC (below major hepatic veins), controlling left renal vein, lumbar veins, short hepatic veins and ligating right renal artery. Once retrohepatic IVC is circumferentially dissected and the vascular control is achieved, sequential clamping is performed with Rummel tourniquets and blood flow cessation is assessed with laparoscopic ultrasound. Cavotomy is done and the entire thrombus is removed en bloc with right renal vein, previously transected with Endo GIA. Cavotomy closure is done with running suture, tourniquets are released to restore caval flow and radical nephrectomy with lymph node dissection is completed. This group routinely performs preoperative angioembolization of renal artery. Both studies, despite of cases and short follow-up comparing to open surgery series, report similar intraoperative results, as well as similar oncological
DMD049460 362..371

The plasma concentration of repaglinide is reported to increase greatly when given after repeated oral administration of itraconazole and gemfibrozil. The present study analyzed this interaction based on a physiologically based pharmacokinetic (PBPK) model incorporating inhibition of the hepatic uptake transporter and metabolic enzymes involved in repaglinide disposition. Firstly, the plasma concentration profiles of inhibitors (itraconazole, gemfibrozil, and gemfibrozil glucuronide) were reproduced by a PBPK model to obtain their pharmacokinetic parameters. The plasma concentration profiles of repaglinide were then analyzed by a PBPK model, together with those of the inhibitors, assuming a competitive inhibition of CYP3A4 by itraconazole, mechanism-based inhibition of CYP2C8 by gemfibrozil glucuronide, and inhibition of organic anion transporting polypeptide (OATP) 1B1 by gemfibrozil and its glucuronide. The plasma concentration profiles of repaglinide were well reproduced by the PBPK model based on the above assumptions, and the optimized values for the inhibition constants (0.0676 nM for itraconazole against CYP3A4; 14.2 mM for gemfibrozil against OATP1B1; and 5.48 mM for gemfibrozil glucuronide against OATP1B1) and the fraction of repaglinide metabolized by CYP2C8 (0.801) were consistent with the reported values. The validity of the obtained parameters was further confirmed by sensitivity analyses and by reproducing the repaglinide concentration increase produced by concomitant gemfibrozil administration at various timings/doses. The present findings suggested that the reported concentration increase of repaglinide, suggestive of synergistic effects of the coadministered inhibitors, can be quantitatively explained by the simultaneous inhibition of the multiple clearance pathways of repaglinide.
4EXPERIMENTS ON SUCROSE FORMATION BY POTATO TUBERS

It has been known that plants alnd plant parts maintained at low teniiperature tend to convert stored starch to sucrose. Thus MULLER-THURGAU (15) early found an accumulation of sugars and a corresponding loss of starch in potatoes kept at temperatures between 00 and 60 C. This work was later repeated and confirmed by WOLFF (20). Higher storage temperatures on the other hand result in an accumulation of reserve carbohydrates in the form of starch. Although the sweeteninr of potatoes, sweet potatoes and other tissues during low temperature storage has then been known for some time, the mechanisms responsible for the starchsucrose conversion have remained obscure, due mainly to the fact that enzymes of the carbohydrate metabolism have been but little studied in higher plants. In animal tissues on the other hand a great deal is known concerning these matters. CORI and CORI (2) isolated from frog muscle glucose-l-PO4 or Cori ester as the iniitial product of phosphorolysis of glycogen. Later they obtained the same ester from rabbit muscle (3) and showed that the presence of the enzyme phosphorylase, is responsible for the reaction. HANES (8) has shown that a similar but not identical phosphorylase is present in pea seeds and in potato tubers (9) and that this enzyme attacks starch with the production of glucose-l-phosphate. This ester may indeed be prepared biologically from starch with the aid of potato phosphorylase (HANES 8, MCCREADY and HASSID 14). The elnzyme has also been found in yeast (12), and many other plant and animal tissues. Although many plant tissues form sucrose on cold storage, the mechanisms involved are unknown. The enzymes of carbohydrate transformation in the potato tuber have been but little investigated, and no investigation appears to have been made on the relation of amount and activity of enzymes of the carbohydrate metabolism in relation to temperature. This paper will consider the carbohydrate metabolism of the potato both as to enzyme mechanisms and as related to temperature.
Durability of Wearable Antennas Based on Nonwoven Conductive Fabrics: Experimental Study on Resistance to Washing and Ironing

Adhesive nonwoven conductive fabrics are appealing materials for fabricating fully textile antennas for wearable wireless systems. Wearable antennas should be flexible, lightweight, and mechanically resistant. Additionally, the antenna performance should be robust to activities related to daily use of garments, such as washing and ironing. Accordingly, in this work, the results of several washing tests performed on fully textile antennas fabricated by exploiting three different adhesive nonwoven conductive fabrics are reported.
Evaluation genetique des chevaux a partir de leurs classement en competition

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Evaluation genetique des chevaux a partir de leurs classement en competition Alice Tavernier
A Low Power WSNs Attack Detection and Isolation Mechanism for Critical Smart Grid Applications

Wireless sensor networks (WSNs) are effective tools in many smart grid applications such as remote monitoring, equipment fault diagnostic, wireless advanced metering infrastructure, and residential energy management. WSNs are attractive tools due to their low cost, dynamic nature, ruggedness, and low-power profile. Maintaining a low-power profile is a critical design factor in WSNs. Therefore, implementing sophisticated quality of service protocols and security mechanisms in WSNs is a challenging task. Furthermore, WSNs security mechanisms should not only focus on reducing the power consumption of the sensor devices but also they should maintain high reliability and throughput needed by smart grid applications. In this paper, we present a low-power cyber-security mechanism for WSNs-based smart grid monitoring applications. Our mechanism can detect and isolate various attacks such as the denial of sleep, forge, and replay attacks in an energy efficient way. The simulation results show that our mechanism can outperform existing techniques in power efficiency while maintaining constant delay and reliability values.
Renormalisation group ﬂows of boundary theories

: We review recent developments in the theory of renormalisation group ﬂows in minimal models with boundaries. Among these, we discuss in particular the perturbative calculations of Recknagel et al, not only as a tool to predict the IR endpoints of certain ﬂows, but also as a motivation for considering the particular limiting case of c = 1. By treating this limit, we are able to investigate a wide class of perturbations by considering them as deformations away from the c = 1 point. We also present the truncated conformal space approach as a tool for investigating the space of RG ﬂows and checking particular predictions.
University of Birmingham The inter-relationship of symptom severity and quality of life in 2055 patients with primary biliary cholangitis

Citation for published version (Harvard): Dyson, JK, Wilkinson, N, Jopson, L, Mells, G, Bathgate, A, Heneghan, MA, Neuberger, J, Hirschfield, GM, Ducker, SJ, UK Primary Biliary Cirrhosis (PBC) Consortium, Sandford, R, Alexander, G, Stocken, D & Jones, DEJ 2016, 'The inter-relationship of symptom severity and quality of life in 2055 patients with primary biliary cholangitis', Alimentary Pharmacology & Therapeutics, vol. 44, no. 10, pp. 1039-1050. https://doi.org/10.1111/apt.13794