Miracle-dz/UniFAR-FTUs huggingface dataset:
The transcriptional response to chronic stress and glucocorticoid receptor blockade in the hippocampal dentate gyrus

The dentate gyrus (DG) of the hippocampus plays a crucial role in learning and memory. This subregion is unique in its ability to generate new neurons throughout life and integrate these new neurons into the hippocampal circuitry. Neurogenesis has further been implicated in hippocampal plasticity and depression. Exposure to chronic stress affects DG function and morphology and suppresses neurogenesis and long‐term potentiation (LTP) with consequences for cognition. Previous studies demonstrated that glucocorticoid receptor (GR) blockade by a brief treatment with the GR antagonist mifepristone (RU486) rapidly reverses the stress and glucocorticoid effects on neurogenesis. The molecular pathways underlying both the stress‐induced effects and the RU486 effects on the DG are, however, largely unknown. The aim of this study was therefore (1) to investigate by microarray analysis which genes and pathways in the DG are sensitive to chronic stress and (2) to investigate to what extent blockade of GR can normalize these stress‐induced effects on DG gene expression. Chronic stress exposure affected the expression of 90 genes in the DG (P < 0.01), with an overrepresentation of genes involved in brain development and morphogenesis and synaptic transmission. RU486 treatment of stressed animals affected expression of 107 genes; however, mostly different genes than those responding to stress. Interestingly, we found CREBBP to be normalized by RU486 treatment to levels observed in control animals, suggesting that CREB‐signaling may play a central role in mediating the chronic stress effects on neurogenesis, LTP and calcium currents. The identified genetic pathways provide insight into the stress‐induced adaptive plasticity of the hippocampal DG that is so central in learning and memory and will direct future studies on the functional outcome and modulation of these stress effects. © 2010 Wiley Periodicals, Inc.
Robust secure beamforming for SWIPT systems with full-duplex receivers and energy-harvesting eavesdroppers

In this paper, we consider a simultaneous wireless information and power transfer (SWIPT) system with a full-duplex (FD) receiver and an energy-harvesting (EH) eavesdropper. The FD receiver decodes the information that should be kept secret from the EH eavesdropper and sends jamming signals to degrade the eavesdropper simultaneously using the energy it harvests from the source. An optimization problem is formulated to maximize the worst-case secrecy rate taking into account the eavesdropper channel uncertainties. A SDR-based method is proposed to solve this problem. Numerical results are given to show the superiority of our proposed scheme.
Evaluating the Association of Workplace Psychosocial Stressors with Occupational Injury, Illness, and Assault

This research project characterizes occupational injuries, illnesses, and assaults (OIIAs) as a negative outcome associated with worker exposure to generalized workplace abuse/harassment, sexual harassment, and job threat and pressure. Data were collected in a nationwide random-digit-dial telephone survey conducted during 2003–2004. There were 2151 study interviews conducted in English and Spanish. Analyses included cross tabulation with Pearson's Chi-Square and logistic regression analyses. Three hundred and fifty-one study participants reported having an OIIA during the 12 months preceding the study. Occurrences of generalized workplace harassment (OR = 1.53; CI = 1.33–1.75, p ⩽ 0.05); sexual harassment (OR = 1. 18; CI = 1.04–.34, p ⩽ 0.05); and job pressure and threat (OR = 1.26; CI = 1.10–1.45, p ⩽ 0.05) were significantly associated with reporting an OIIA. The psychosocial environment is significantly associated with an increased risk of OIIA. Further research is needed to understand causal pathways and to explore potential interventions.
Depression among persons attending a HIV/AIDS outpatient clinic in Kingston, Jamaica.

OBJECTIVES To determine the prevalence of depression among persons attending a HIV/AIDS clinic in Kingston, Jamaica, and to explore the possible role of patient-specific clinical and social issues as intermediary factors in the relationship between HIV/AIDS and depression. SUBJECTS AND METHODS Over a three-month period, all eligible and consenting patients from a HIV/ AIDS clinic in Kingston, Jamaica, were invited to participate in the study. They were interviewed using the Patient Health Questionnaire (PHQ-9), an instrument validated for the detection of depression in primary care settings. Clinical and socio-demographic data were retrieved for all participating patients from a pre-existing clinic database. Depression prevalence rates were calculated and the association between depression and age, gender, antiretroviral treatment, CD4 count, living arrangement, marital status and major stressors explored. RESULTS Sixty-three patients participated in the study and 43% (n = 36) of them were depressed. No significant differences in depression rates were found with respect to any of the sociodemographic or clinicalfactors explored (p > 0.05). CONCLUSION The relatively high prevalence of depression among attendees at the HIV/AIDS clinic underscores the need for depression screening in these patients.
Operating charts for the Brushless Doubly-Fed Machine (BDFM)

The Brushless Doubly-Fed Machine (BDFM) is an electrical machine that allows brushless operation in many applications where the Doubly-Fed Induction Generator (DFIG) is currently used. In recent years work on BDFM control means that the machine can now be run stably across its working range. However, little work has been done to define the working area in which BDFM can safely be operated without exceeding its material and stability limits. This paper sets out the theoretical backing for an operating chart of an ideal BDFM similar to that of the synchronous machine. It goes on to show that though the ideal chart gives the right form, non-ideal parameters (especially the finite magnetizing inductances) significantly effect the locations of the limits. Some preliminary experimental data obtained for a 225 frame size machine support the form of the chart. Finally it is shown how the operating chart can be used to chose appropriately sized converters for the BDFM.
Enhancing Reading Skills and Reading Self-Concept of Children with Reading Difficulties: Adopting a Dual Approach Intervention.

This article describes the need for, and the structure and contents of, a reading program to help support children disadvantaged by reading difficulties. The program, delivered by trained and supported volunteers, lasts for 15 weeks. It uses a novel dual approach which aims to improve students’ reading skills and simultaneously enhance their reading-related self-concepts. As there is scant literature available on how to implement such a program, this article aims to address that limitation by demonstrating to educators how such a dual approach to enhancing reading skills and reading self-concept can be operationalized.
Active compensation for critical coupling deviation on a single-arm silicon microring by free-carrier absorption

We present active critical coupling compensation by employing the free-carrier absorption for a single-arm silicon microring device when the microring has fabrication error to deviate from critical coupling. It is possible to re-establish the critical coupling for the MOS capacitor microring by applying gate voltage within 10 V when the gap width fabrication error is within the ITRS 90 nm CMOS technology node.
Collagen XIII secures pre- and postsynaptic integrity of the neuromuscular synapse

Both transmembrane and extracellular cues, one of which is collagen XIII, regulate the formation and function of the neuromuscular synapse, and their absence results in myasthenia. We show that the phenotypical changes in collagen XIII knock-out mice are milder than symptoms in human patients, but the Col13a1-/- mice recapitulate major muscle findings of congenital myasthenic syndrome type 19 and serve as a disease model. In the lack of collagen XIII neuromuscular synapses do not reach full size, alignment, complexity and function resulting in reduced muscle strength. Collagen XIII is particularly important for the preterminal integrity, and when absent, destabilization of the motor nerves results in muscle regeneration and in atrophy especially in the case of slow muscle fibers. Collagen XIII was found to affect synaptic integrity through binding the ColQ tail of acetylcholine esterase. Although collagen XIII is a muscle-bound transmembrane molecule, it also undergoes ectodomain shedding to become a synaptic basal lamina component. We investigated the two forms' roles by novel Col13a1tm/tm mice in which ectodomain shedding is impaired. While postsynaptic maturation, terminal branching and neurotransmission was exaggerated in the Col13a1tm/tm mice, the transmembrane form's presence sufficed to prevent defects in transsynaptic adhesion, Schwann cell invagination/retraction, vesicle accumulation and acetylcholine receptor clustering and acetylcholinesterase dispersion seen in the Col13a1-/- mice, pointing to the transmembrane form as the major conductor of collagen XIII effects. Altogether, collagen XIII secures postsynaptic, synaptic and presynaptic integrity, and it is required for gaining and maintaining normal size, complexity and functional capacity of the neuromuscular synapse.
Current surgical approach for left ventricular restoration

Coronary artery disease is not a simple coronary lesion that causes angina, but also combined heart problem that leads to severe ischemic complications as dilated heart failure, valve insufficiencies, heart rhythm disturbances, thrombus formation to secondary ischemic/embolic complications. In order to manage it, several worldwide surgical treatment months, wound assessment, measurement of limb oxygenation, ankle brachial pressures as well as McGill pain questionnaire will be carried out. Blood will also be collected at baseline and at the end of every month of the treatment period (for a total of 5 collections) for the measurement of different biomarkers were divided in two groups: Those with ST elevation myocardial infarction (STEMI) (Group 1, 54 patients), and those with non-ST elevation. We present here our single center and initial experience on surgical approach for left ventricular restorations and, we found it in conclusion that the outcome of these procedures was quite sufficient.
The Bromination Of p‐Aminosalicylic Acid, Sodium p‐Aminosalicylate And m‐Aminophenol

1 The bromination of p‐aminosalicylic acid, sodium p‐aminosalicylate and m‐aminophenol has been studied using a variable excess of bromide/bromate solution. 2 p‐Aminosalicylic acid, sodium p‐aminosalicylate and m‐amino phenol brominate quantitatively regardless of the excess of bromide/bromate solution used. 3 The basis for an assay process for p‐aminosalicylic acid, sodium p‐aminosalicylate and m‐aminophenol has been described. Thanks are expressed to the Directors of Herts Pharmaceuticals Limited for permission to publish these results.
Homologs of the essential ubiquitin conjugating enzymes UBC1, 4, and 5 in yeast are encoded by a multigene family in Arabidopsis thaliana.

The covalent attachment of the 76 amino acid protein ubiquitin is an important prerequisite for the degradation of many eukaryotic proteins. The specificity of this ligation is accomplished in part by a family of distinct ubiquitin conjugating enzymes (E2s) working in concert with specific ubiquitin-protein ligases (E3s). Three essential E2s in yeast encoded by ScUBC1, -4, and -5 comprise a functionally overlapping E2 subfamily that appears responsible for degrading most abnormal and short-lived proteins. A 15 kDa E2 protein homologous to this family has been identified previously in wheat germ, designated TaE2(15kDa) (Girod and Vierstra (1993) J. Biol. Chem. 268, 955-960). This E2 is responsible for much of the ubiquitin conjugating activity observed in wheat germ extracts and works together with a unique E3 (designated E3 gamma) for substrate recognition. In this paper, the cloning of five genes encoding E2(15kDa) from Arabidiopsis thaliana is described (designated AtUBC8-12). They encode 149 amino acid basic proteins 94-98% similar to each other and 88-92% similar to ScUBC4 at the amino acid sequence level. In contrast, AtUBC8-12 are only 55-65% similar to the Arabidopsis E2s encoded by AtUBC1, -4, and -7. The AtUBC8-12 proteins do not contain N- or C-terminal extensions and have the active site at residue Cys-86, based on their homology with other E2s. Analyses of genomic Southern blots are consistent with the existence of multiple members encoding this E2 subfamily. AtUBC8-12 are transcribed to yield about 800 nucleotide mRNAs that, unlike ScUBC4 and -5, are not strongly induced by heat shock. (ABSTRACT TRUNCATED AT 250 WORDS)
The Designs and Methods Of Published Nursing Research: 1956–1983

This study describes the relative frequencies over time of designs and methods used in nursing research articles published in three refereed journals. All articles published in 1956, 1961, 1966, 1971, 1976, 1981, and 1983 were reviewed (N = 434); 83% were research articles. Methodological research comprised 11% and historical research 1% of the 362 research articles. The designs of the remaining 317 research reports were classified as experimental (27%) or observational (73%). Use of experimental designs peaked in the mid-1960s (41%) and appears to be on the decline (20% in 1983). Cross-sectional studies predominated throughout the period (49%). Methods, including types of subjects, sample selection, and data collection instruments, are described and analyzed for time trends. The findings are discussed in light of the designs and methods advocated in nursing texts and literature.
False positive reduction for ground glass opacities in CT by feature analysis based on a multiple region extraction technique

In our previous method, thresholding for feature extraction was one of the biggest problems. We have developed two methods for obtaining the optimal threshold, but they are not enough to apply to all the cancers in CT. In this paper, we prepared about 9 thresholds and extracted features by using these thresholds. Then we applied a discriminate method using a subspace derived from the extracted feature metrices.
Clustered nuclei splitting via curvature information and gray‐scale distance transform

Clusters or clumps of cells or nuclei are frequently observed in two dimensional images of thick tissue sections. Correct and accurate segmentation of overlapping cells and nuclei is important for many biological and biomedical applications. Many existing algorithms split clumps through the binarization of the input images; therefore, the intensity information of the original image is lost during this process. In this paper, we present a curvature information, gray scale distance transform, and shortest path splitting line‐based algorithm which can make full use of the concavity and image intensity information to find out markers, each of which represents an individual object, and detect accurate splitting lines between objects using shortest path and junction adjustment. The proposed algorithm is tested on both synthetic and real nuclei images. Experiment results show that the performance of the proposed method is better than that of marker‐controlled watershed method and ellipse fitting method.
Assessment of pulmonary airway calibre.

The assessment of airway calibre is of relevance to anaesthetic practice for the following reasons. Clinical management of patients before or after anaesthesia and during intensive respiratory care often requires information about the degree of patency of airways. Following induction of general anaesthesia there may be considerable difficulty in inflating the lungs and this may be interpreted either as an increase in airways resistance or as a decrease in compliance. Clinical criteria do not enable a distinction to be made between these two entities. When measurements of resistance are made during general anaesthesia we have shown (Lehane, Jordan and Jones, 1980) that large changes occur which are undetectable clinically. Many drugs used in anaesthetic practice may influence airway calibre and methods are required for evaluating these effects in both conscious and anaesthetized patients.
Lipid Replacement Therapy with a Glycophospholipid Formulation with NADH and CoQ10 Significantly Reduces Fatigue in Intractable Chronic Fatiguing Illnesses and Chronic Lyme Disease Patients

Objectives: A preliminary open label study was initiated to determine if a combination oral supplement containing a mixture of phosphoglycolipids, coenzyme Q10 and microencapsulated NADH could affect fatigue levels in long-term patients with intractable fatigue. Fatigue was determined by the validated Piper Fatigue Scale before, during and after the trial. Participants included 58 patients (30 females and 28 males) with chronic fatigue syndrome/myalgic encephalomyelitis, chronic Lyme disease or other fatiguing illnesses, such as fibromyalgia syndrome or Gulf War illness. These patients had been symptomatic for an average of 17.1 ± 0.6 years, had been seen by many physicians (15.2 ± 0.7) and had used many other supplements and drugs (35.4 ± 2.7) without apparent reductions in their fatigue. Results: Participants in the study responded to the combination test supplement, showing a 30.7% reduction in overall fatigue within 60 days (P < 0.001). Analysis of subcategories of fatigue indicated that there were significant improvements in the ability to complete tasks and activities as well as significant improvements in mood and cognitive abilities. Regression analysis of the data indicated that reductions in fatigue were gradual, consistent, and occurred with a high degree of confidence (R 2 = 0.960). The data also suggested that further reductions were likely if the participants had continued the supplement beyond the 8-week trial. Males responded slightly better to the combination supplement than females, and the patients with the most severe forms of fatigue responded slightly better than those with milder fatigue, independent of their diagnosis. Conclusions: The combination supplement was a safe and effective method to significantly reduce fatigue in long-term patients with intractable chronic fatigue.
Nonlinear Energy Transfer among Ocean Internal Waves in the Wake of a Moving Cyclone

AbstractThe nonlinear dynamics leading to the generation of superinertial internal waves in the ocean, in the wake of a cyclonic storm, is investigated by means of theoretical arguments and of numerical integration of the hydrostatic Boussinesq equations in a simplified, realistic, open-ocean setting. The velocity fields are first decomposed into internal baroclinic modes, and then the energy transfer across modes and at different frequencies is calculated analytically. The energy transfer across modes is dominated by the advection of high-mode m waves by the second- and third-mode waves (n = 2 or 3), which are the most energetic, and this results in the excitation of the l = m − 2 or m − 3 mode wave at the double-inertial frequency. The analyzed nonlinear interactions lead to a transfer of energy from near-inertial waves, directly excited by the storm, to superinertial waves, which typically propagate faster and farther than their lower-frequency parents and can lead to internal mixing even at large dist.
A design for the repair of unilateral cleft lips.

the cIeft to restore symmetry and aIso preserved a full Cupid’s bow. Marcks and co-workers, in 1953, reported excehent resuIts using simiIar technics. In 1955 Millard [j] presented a new design for this type of repair. He employed curved incisions corresponding to the caIcuIated phiItrum Iine on the cleft side and added length to this side of the lip by extending the media1 incision underneath the coIumeIIa so that the entire central part of the Iip was brought down to the correct IeveI. I have used these two methods in cases of uniIatera1 cleft lips with varying degrees of deformity, and the operative results with both methods have been very satisfying, particuIarIy in incomplete cIefts. The former method, however, involved considerabIe sacrifice of tissue in complete cIefts, and using the Millard technic I found it diffxcult to avoid retraction of the scar line at the vermiIion border. Based upon this experience a repair was designed which used two flaps for eIongation of the cleft B
SPOC form based tracking and estimation of harmonic signals with unknown frequencies

A new approach to estimation and tracking of harmonic signal with unknown amplitude, frequency and phase is presented. The algorithm is based on the States and Parameters Observability Canonical (SPOC) form representation. This representation allows simultaneous state and parameter estimation of uncertain linear time-invariant system. The proposed algorithm has been applied to noisy measurement of single harmonic signals with constant unknown frequency and to harmonic signal composed of two sine waves. Simulation results demonstrate the usefulness of the proposed algorithm.
A Topic-Independent Method for Scoring Student Essay Content

This paper proposes a topic-independent method for automatically scoring essay content. Unlike conventional topic-dependent methods, it predicts the human-assigned score of a given essay without training essays written to the same topic as the target essay. To achieve this, this paper introduces a new measure called MIDF that measures how important and relevant a word is in a given essay. The proposed method predicts the score relying on the distribution of MIDF. Surprisingly, experiments show that the proposed method achieves an accuracy of 0.848 and performs as well as or even better than conventional topic-dependent methods.
Analysis of noise impact on geo-object recognition in infrared bands using simulated data

Infrared spectrums play an important role in the information extraction of rock and minerals. Spectrum simulation is a fundamental issue of land surface scene simulation and image simulation of remote sensing systems. Signal to Noise Ratio is regarded as an essential parameter of instrument and remote sensing image. In this study, we used MODTRAN to simulate apparent radiance and different levels of additive white Gaussian noise was added to the simulated spectrum. In the section of noise impact on object recognition, Spectral Feature Fitting was chosen to compare the fit of simulated spectra with different noise levels to reference apparent radiance spectra without noise. Relative error is also calculated for the accuracy assessment which is helpful for validation and improvement of instrument parameters.