Miracle-dz/UniFAR-FTUs huggingface dataset:
Sediment load determines the shape of rivers

Significance Rivers carry and deposit sediment, thereby shaping most landscapes around us. In doing so, their malleable channels change shape to accommodate the sediment load. Here, we show how fluid stress, gravity, and the erratic trajectories of traveling grains combine together to determine the shape of a river. We find that the stress on the bed of a river cannot be significantly above the critical value for sediment motion, which bounds the intensity of sediment transport and, thus, forces the river to widen as its sediment load increases. Although our results relate directly only to experimental, laminar rivers, they likely also apply qualitatively to natural ones, potentially allowing us to use the shape of a river as a proxy for its sediment discharge. Understanding how rivers adjust to the sediment load they carry is critical to predicting the evolution of landscapes. Presently, however, no physically based model reliably captures the dependence of basic river properties, such as its shape or slope, on the discharge of sediment, even in the simple case of laboratory rivers. Here, we show how the balance between fluid stress and gravity acting on the sediment grains, along with cross-stream diffusion of sediment, determines the shape and sediment flux profile of laminar laboratory rivers that carry sediment as bedload. Using this model, which reliably reproduces the experiments without any tuning, we confirm the hypothesis, originally proposed by Parker [G. Parker, J. Fluid Mech. 89, 127–146 (1978)], that rivers are restricted to exist close to the threshold of sediment motion (within about 20%). This limit is set by the fluid–sediment interaction and is independent of the water and sediment load carried by the river. Thus, as the total sediment discharge increases, the intensity of sediment flux (sediment discharge per unit width) in a river saturates, and the river can transport more sediment only by widening. In this large discharge regime, the cross-stream diffusion of momentum in the flow permits sediment transport. Conversely, in the weak transport regime, the transported sediment concentrates around the river center without significantly altering the river shape. If this theory holds for natural rivers, the aspect ratio of a river could become a proxy for sediment discharge—a quantity notoriously difficult to measure in the field.
The use of in vitro methods in assessing human health risks associated with short‐chain perfluoroalkyl and polyfluoroalkyl substances (PFAS)

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a large class of industrial chemicals with a ubiquitous and persistent presence in the environment. Of the thousands of PFAS used by consumers and industry, very few have been thoroughly characterized for potential adverse effects. This is especially true for the novel short‐chain (C < 8) alternatives that replaced legacy PFAS. Perfluoroalkyl and polyfluoroalkyl substances have revealed inconsistencies in the toxicokinetics predicted by animal models and empirical findings in humans. To adequately assess the possible health effects of short‐chain PFAS, there is a need for robust aggregated data sets on the mechanistic underpinnings and physiochemical properties of these alternatives. Acquiring relevant data on the health effects of short‐chain PFAS can be achieved through high‐throughput methods supported by in vitro human cell‐based models. This review briefly summarizes some of the toxicity data obtained using human cells in vitro, discusses the advantages and limitations of cell‐based models, and provides insights on potential solutions to challenges presented with the use of these methods for use in safety assessments.
A Qualitative Analysis of Mexican-Origin Men’s Knowledge and Cultural Attitudes Toward Non-Alcoholic Fatty Liver Disease and Interest in Risk Reduction

Mexican-origin men are at increased risk of developing non-alcoholic fatty liver disease (NAFLD). The purpose of this qualitative research was to assess Mexican-origin men’s knowledge and cultural attitudes toward NAFLD and their interest in risk reduction. Semi-structured interviews were conducted with 11 Spanish-speaking Mexican-origin men who were considered high-risk of having NAFLD according to transient elastography (FibroScan®) continuous attenuation parameter (CAP) scores (≥280). Audio recordings of these interviews were transcribed and interpreted in their respective language to facilitate data analysis using NVivo 12. A thematic codebook was developed, from which the research team identified emerging themes. Findings demonstrated limited knowledge about NAFLD and in general chronic liver disease among Mexican-origin men. Cultural attitudes appeared to both enhance and mitigate their perceived risk for NAFLD. Interviews also revealed high interest levels for reducing NAFLD risk, with family and loved ones acting as the main motivators for engagement in healthier behaviors. Inclination toward family-based interventions was reported as a subject of interest for this high-risk population. This qualitative study suggests that the development of a NAFLD-specific intervention approach for Mexican-origin men may be feasible and should consider a familial and cultural context centered in improving lifestyle health behaviors.
Ultrasound Measurement of Rectus Femoris Muscle Parameters for Discriminating Sarcopenia in Community‐Dwelling Adults

Sarcopenia patients require more medical attention and caretaking. As such, early detection of sarcopenia and appropriate interventions are crucial for decreasing medical costs and meeting the challenges of aging populations. The aim of the present study was to develop a reliable and accurate model to estimate muscle mass using ultrasound‐derived parameters from the rectus femoris (RF), referenced by dual‐energy X‐ray absorptiometry.
Unsteady Ejector Performance: An Experimental Investigation Using a Resonance Tube Driver

AbstractA statistically designed experiment to characterizethrust augmentation for unsteady ejectors has beenconducted at the NASA Glenn Research Center. Thevariable parameters included ejector diameter, length,and nose radius. The pulsed jet driving the ejectors wasproduced by a shrouded resonance (or Hartmann-Sprenger) tube. In contrast to steady ejectors, anoptimum ejector diameter was found, which coincidedwith the diameter of the vortex ring created at thepulsed jet exit. Measurements of ejector exit velocityusing a hot-wire permitted evaluation of the massaugmentation ratio, which was found to correlate tothrust augmentation following a formula derived forsteady ejectors.IntroductionCurrently, efforts are underway to explore the use ofpulsed detonation engines (PDE) for aerospacepropulsion. Technical issues involved includeintegration, noise, and thrust to weight ratio. Adding anejector to a PDE may enhance thrust, and reduce noise.The ejector will then be driven by a pulsating flow. Paststudies of unsteady ejectors
The role of circular RNA plasmacytoma variant translocation 1 as a biomarker for prognostication of acute myeloid leukemia

ABSTRACT Objective Circular RNA plasmacytoma variant translocation 1 (circ-PVT1) has been reported to be an oncogene and serves as a prognostic biomarker in several solid cancers and hematological malignancies. However, no study has been performed on the tumorigenesis role of circ-PVT1 in acute myeloid leukemia (AML). Thus, this study aimed to evaluate the correlation of circ-PVT1 with disease risk, clinical characteristics, cytogenetics/molecular genetics, and prognosis of AML. Methods A total of 68 de novo AML patients, 30 disease controls and 30 health donors were enrolled in this study. Circ-PVT1 expression in bone marrow (BM) was determined. Complete remission (CR) status after induction therapy, event-free survival (EFS) and overall survival (OS) were evaluated in AML patients. Results Circ-PVT1 expression was different among AML patients, disease controls and health donors, which was highest in AML patients, followed by disease controls and lowest in health donors. Meanwhile, circ-PVT1 could distinguish AML patients from health donors and disease controls by receiver operating characteristic curve analysis. Furthermore, circ-PVT1 was correlated with BM blasts and FLT3-ITD mutation, but not other clinical features, such as French-American-Britain subtypes in AML patients. Moreover, circ-PVT1 expression was lower in AML patients with CR compared with those without CR. Besides, high circ-PVT1 expression was correlated with shorter EFS and OS in AML patients. After adjustment by multivariate Cox’s regression analysis, higher circ-PVT1 expression was an independent factor in predicting shorter EFS and OS for AML patients. Conclusion Circ-PVT1 potentially serves as a biomarker for evaluating the prognosis of AML patients.
Diffusion-Weighted Magnetic Resonance Imaging of 103 Patients with Rectal Adenocarcinoma Identifies the Apparent Diffusion Coefficient as an Imaging Marker for Tumor Invasion and Regional Lymph Node Involvement

Background This retrospective study included 103 patients diagnosed with rectal adenocarcinoma at a single center in Poland who underwent preoperative diffusion-weighted magnetic resonance imaging (DWI) and aimed to determine whether the apparent diffusion coefficient (ADC) was an imaging marker for tumor invasion and regional lymph node involvement. Material/Methods We analyzed primary staging magnetic resonance examinations of the rectum of 103 consecutive patients with histologically proven non-mucinous adenocarcinoma who underwent surgical treatment. In 85 patients, surgery was preceded by long-course chemoradiotherapy (n=18) or short-course radiotherapy (n=67). The following DWI parameters were measured: ADC mean, minimum, maximum, and standard deviation in the region of interest (ADC SD-in-ROI). Values were compared between subgroups based on histological parameters from the report: tumor stage, lymph node stage, differentiation grade, the presence of extranodal tumor deposits, angioinvasion, and perineural invasion. Statistical analysis was performed using the Mann-Whitney U test and the unilateral t test. Results ADC mean values were lower for cases in which postoperative histopathological examination lymph node invasion (P=0.04) and tumor deposits were found (P=0.04). Minimal ADC value was higher in cases in which tumor deposits were not found (P=0.009). ADC SD-in-ROI values were lower in cases in which lymph nodes invasion was confirmed (P=0.014). There were no statistically significant differences for other parameters. Conclusions The ADC values in pre-treatment DWI in patients with rectal adenocarcinoma were correlated with tumor invasion and regional lymph node metastases. Therefore, ADC values from the pre-treatment MRI may help plan adjuvant therapy in patients with rectal adenocarcinoma.
Path Following and Stabilization of an Autonomous Bicycle

In this thesis we investigate the problem of designing a control system for a modern bicycle so that the bicycle is stable and follows a path. We propose a multi-loop control architecture, where each loop is systematically designed using linear control techniques. The proposed strategy guarantees that the bicycle asymptotically converges to paths of constant curvature. A key advantage of our approach is that by using linear techniques analysis and controller design are relatively simple. We base our control design on the nonlinear (corrected) Whipple model, which has been previously verified for correctness and experimentally validated. The equations of motion for the nonlinear model are very complicated, and would take many pages to explicitly state. They also have no known closed form solution. To enable analysis of the model we linearize it about a trajectory such that the bicycle is upright and travelling straight ahead. This linearization allows us to arrive at a parameterized linear time-invariant state-space representation of the bicycle dynamics, suitable for analysis and control design. The inner-loop control consists of a forward-speed controller as well as a lean and steer controller. To keep the bicycle at a constant forward speed, we develop a high-bandwidth proportional controller that uses a torque along the axis of the rear wheel of the bicycle to keep the angular velocity of the rear wheel at a constant setpoint. To stabilize the bicycle at this forward speed, lean torque and steer torque are treated as the control signals. We design a state-feedback controller and augment integrators to the output feedback of the lean angle and steer angle to provide perfect steady-state tracking. To arrive at the gains for state feedback, linear-quadratic regulator methods are used. When following a constant-curvature path, a vehicle has a constant yaw rate. Using this knowledge, we begin designing the outer-loop path-following control by finding a map that converts a yaw rate into appropriate lean angle and steer angle references for the inner loop. After the map is completed, system identification is performed by applying a yaw-rate reference to the map and analyzing the response of the bicycle. Using the linear approximation obtained, a classical feedback controller for yaw-rate tracking is designed. In addition to yaw-rate control, to track a path the yaw angle of the bicycle must match that of the path and the bicycle must physically be on the path. To analyze these conditions a linear approximation for the distance between the bicycle to the path is found, enabling construction of a linear approximation of the entire system. We then find that by passing the signal for the difference in yaw rate and the distance through separate controllers, summing their output, and subtracting from the reference yaw rate of the path, the bicycle converges to the path.
Distinct roles of hnRNPH1 low-complexity domains in splicing and transcription

Significance Phase separation of low-complexity (LC) domains appended to most RNA-binding proteins (RBPs) emerges as a principle underlying spatiotemporal protein recruitment. Yet, how LC domains regulate the function of RBPs in cells remains unclear. An alternative-splicing regulator, hnRNPH1, contains two LC domains (LC1 and LC2). Here, we show that phase separation of the LC1 can exert control over hnRNPH1 function in RNA-splicing possibly by facilitating interactions between hnRNPH1 and a variety of RBPs. In contrast, the LC2 lacking in vitro phase properties, is required for aberrant transcriptional activation in the context of fusion oncoproteins. These results have broad implications for understanding how phase separation contributes to distinct roles of LC domains in control of physiological as well as oncogenic functions. Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins that control key events in RNA biogenesis under both normal and diseased cellular conditions. The low-complexity (LC) domain of hnRNPs can become liquid-like droplets or reversible amyloid-like polymers by phase separation. Yet, whether phase separation of the LC domains contributes to physiological functions of hnRNPs remains unclear. hnRNPH1 contains two LC domains, LC1 and LC2. Here, we show that reversible phase separation of the LC1 domain is critical for both interaction with different kinds of RNA-binding proteins and control of the alternative-splicing activity of hnRNPH1. Interestingly, although not required for phase separation, the LC2 domain contributes to the robust transcriptional activation of hnRNPH1 when fused to the DNA-binding domain, as found recently in acute lymphoblastic leukemia. Our data suggest that the ability of the LC1 domain to phase-separate into reversible polymers or liquid-like droplets is essential for function of hnRNPH1 as an alternative RNA-splicing regulator, whereas the LC2 domain may contribute to the aberrant transcriptional activity responsible for cancer transformation.
Design-Build-Finance in the US: The case of iROX, I-75 Road Expansion Project

This project is part of the Interstate 75 road expansion, located in Southwest Florida and consisted of an expansion from four to six lanes along a 30-mile stretch. The paper presents a design, build and finance (DBF) approach applied to a US highway. This work focuses on the financial structure of the project, which did not include a concession (operation); the bidding procedure, which took into account an interesting bid evaluation criterion and; project management matters. The information on the case study was acquired by exhaustively examining the documentation of the project and by interviewing the Project Controls Manager. The financial structure used in the project showed that it is possible to extend the payment period beyond the construction deadline without resorting to a toll system. As usual, the bid evaluation criteria of this project included price, time and technical background; however, these aspects were evaluated through the use of a compensated score. Finally, some interesting management aspects of the project are addressed, in order to generate some recommendations for future DBF projects in the US and the world. Key words: Design-Build-Finance project, transportation construction projects, management.
Structured Interview of Reported Symptoms-2nd Edition (SIRS-2): Use and Admissibility in Forensic Mental Health Assessment

Abstract Assessment of symptom feigning is paramount in forensic psychological and psychiatric assessment. The Structured Interview of Reported Symptoms, 2nd Edition (SIRS-2; Rogers et al., 2010) is a revised edition to the original SIRS (Rogers et al., Structured Interview of Reported Symptoms (SIRS) and professional manual. Psychological Assessment Resources, Inc, 1992) and was developed to assess feigned psychiatric symptoms. The current paper reviews use of the SIRS-2 in forensic assessment, specifically addressing topics such as translations of the instrument, its use in assessing psychiatric and cognitive feigning, and its use in special populations. Empirical foundation and psychometric properties of the SIRS-2 is also covered. The SIRS-2 was revised in part to reduce false positive classifications of feigning. Research suggests that this goal was largely accomplished, albeit at the expense of reduced sensitivity. The paper also provides a review of federal and state appellate cases that mention the SIRS-2. Notably, most cases that cite the SIRS-2 do not actually center on the SIRS-2, and the test’s admissibility has never been outrightly challenged. The paper concludes with a discussion of expert testimony concerning the SIRS-2.
Demographic factors and delay of treatment for alcohol use disorders among 6584 Danish men receiving alcohol treatment

Abstract Purpose This study aimed to investigate the time lag between onset and treatment (treatment delay) for alcohol use disorders (AUD) and associations between demographic factors and treatment delay for AUD. Methods The study included 6,584 men registered in the Copenhagen Alcohol Cohort, containing information on civil status, employment status, estimated age at onset of alcohol problems, and age at first outpatient AUD treatment. Data on year of birth, intelligence, and educational level were obtained from the Danish Conscription Database. Information on first hospital AUD treatment was retrieved from Danish national psychiatric registers. Associations between the demographic factors and treatment delay were analysed in separate linear regression models adjusted for year of birth and in a mutually adjusted model including all demographic factors. Results The mean treatment delay for AUD was 6.9 years (SD = 4.1). After mutual adjustment, an SD increase in intelligence score was associated with 0.17 years increase in treatment delay. Educational level was unrelated to treatment delay. Men with estimated age at onset of alcohol problems at age 20 years or younger had a 5.30 years longer treatment delay than men who had estimated age at onset of alcohol problems at age 51 years or older. Employed men had shorter treatment delays than unemployed men, especially among the oldest birth cohorts. Conclusions The treatment delay of 6.9 years highlights the necessity to promote access to AUD treatment, perhaps in particular among adolescents and young individuals. Cognitive factors may affect treatment delay more than non-cognitive personal factors.
Forming Real-World Human-Robot Cooperation for Tasks With General Goal

In human-robot cooperation, the robot cooperates with humans to accomplish the task together. Existing approaches assume the human has a specific goal during the cooperation, and the robot infers and acts toward it. However, in real-world environments, a human usually only has a general goal (e.g., general direction or area in motion planning) at the beginning of the cooperation, which needs to be clarified to a specific goal (i.e., an exact position) during cooperation. The specification process is interactive and dynamic, which depends on the environment and the partner’s behavior. The robot that does not consider the goal specification process may cause frustration to the human partner, elongate the time to come to an agreement, and compromise team performance. This work presents the Evolutionary Value Learning approach to model the dynamics of the goal specification process with State-based Multivariate Bayesian Inference and goal specificity-related features. This model enables the robot to enhance the process of the human’s goal specification actively and find a cooperative policy in a Deep Reinforcement Learning manner. Our method outperforms existing methods with faster goal specification processes and better team performance in a dynamic ball balancing task with real human subjects.
Design of parallel sources in DC distributed power systems by using gain-scheduling technique

In this work, the issue of load sharing between parallel-connected three-phase PWM boost rectifiers is analyzed. In order to achieve independence between the rectifiers to facilitate standardized module design, the droop method is adopted. Traditionally, the method involves a trade-off between voltage regulation and load sharing. After parametric analysis, a novel droop method is proposed to avoid those limitations by using the gain scheduling technique. The analysis shows that the proposed method can achieve both good voltage regulation and good load sharing. The source output impedance of the proposed method is also proven to be better than that of the commonly used master/slave method.
Sonar data conditioning by means of stepwise outlier rejection

Target signature estimation is important in passive sonar signal processing. Higher order spectral methods such as bispectral estimation are often used as a complementary tool to conventional analysis. However, these methods require larger data sets to achieve consistent estimates. The sensitivity for non-stationarities are also more pronounced for bispectral methods. Here, we use a stepwise outlier rejection algorithm as both a stationarity test and a data conditioner for experimental sonar data. We demonstrate the importance of testing for significant quadratic phase coupling and using outlier rejection as a first step in bicoherence analysis of sonar data.