Miracle-dz/UniFAR-FTUs huggingface dataset:
Fetal Outcome in Pregnant Women with Reduced Fetal Movements

Objectives: To analyse the fetal outcome following reduced fetal movements monitored by cardiotocogram and Biophysical Profile Score (BPP) at onset of complaints and before delivery. Material and Methods: Present study was a prospective observational study conducted in the Department of Obstetrics and Gynaecology St. Martha's Hospital over a period of 13 months from 01/03/2009 to 31/03/2010 It included 50 pregnant women after 32 weeks of gestation and singleton pregnancies with 2500 grams, NRCTG (non reactive CTG) at the time of delivery was 42.30% vs 37.50%;( p value 0.393) respectively and was not significantly related. The number of loops of cord and the placental gross morphology were not statistically significant (masked due to small sample size). Conclusions: Although, daily fetal movement counting is subjective, with onset of maternal perception of reduced fetal movements. It is prudent to advocate close fetal monitoring even in the presence of a reactive admission CTG as it is less predictive of adverse fetal outcome than CTG performed before delivery. Hence a non reassuring CTG at delivery is associated with low birth weight, meconium staining of liquor and need for timely obstetric intervention for optimum maternal and fetal outcome.
Drinking among College Students in New England; Extent, Social Correlates and Consequences of Alcohol Use

A survey of over 7000 New England college students revealed that fewer than 5% of both men and women abstain from alcohol, that men tend to drink more than women and that both men and women drink more frequently as they progress in college; high-school drinking patterns were more important than any other variable in determining alcohol use in college.
Prognostic factors in adult Non-Hodgkin's lymphoma patients

Purpose. Over the past 30 years the incidence of the Non-Hodgkin’s lymphoma (NHL) in Europe and in the United States has increased dramatically. The Polish NHL patients have yet significantly poorer survival as compared with the NHL patients in the E.U. countries. The aim of this study was to define prognostic factors determining the prognosis of NHL patients. This could help to select a group of patients who require more intensive treatment. Patients and methods. Ireviewed and reclassified 174 cases of NHL patients treated in the Oncology Clinic of the Jagiellonian University in Krakow in 1971-1999. I estimated some social-economic features of the patients as well as the diagnostic and clinical features of the disease. Results. Univariate analysis showed that there were two groups of factors influencing survival: lack of the abdominal computer tomography examination and certain clinical features of the disease. Therefore I decided to search for prognostic factors among the patients who were properly diagnosed, e.g. who underwent the abdominal computer tomography examination. Multivariate analysis in the group of patients with indolent NHL showed that there were two factors decreasing the overall survival (OS): diffused localisation of the disease and the elevated level of LDH. For disease-free survival (DFS) there was one independent prognostic factor, e.g. the value of International Prognostic Index (IPI). In patients with aggressive NHL the value of IPI significantly influenced the OS and the DFS. In this group I discovered also that anemia decreases the OS. In patients with high-aggressive NHL the independent prognostic for the OS was clinical stage IV and for the DFS the elevated level of LDH. Retrospective analysis revealed that the achievement of the CR substantially improves the OS. Common features that make difficult to achieve the CR in all lymphoma group were: bulky disease with the tumour size over 10 cm, low performance status (>1 according the WHO) and anemia. Conclusion. In summary, my analysis indicates that the improvement of the outcome among the Polish NHL patients is associated with the improvement of the diagnosis. In addition, the high-risk NHL patients according the IPI should be considered as candidates for more intensive treatment. In the high-risk group of indolent NHL patients, chemotherapy combined with immunotherapy is recommended. In the high-risk group of aggressive NHL patients earlier qualification for myeloablative chemotherapy with subsequent PBSCT should be suggested.
FEEL-KJ: vragenlijst voor emotieregulatie bij kinderen en jongeren

kinderen-en-jongeren.html FEEL-KJ Vragenlijst over emotieregulatie bij kinderen en jongeren Caroline Braet, Emiel Cracco, Lotte Theuwis, Alexander Grob, Carola Smolenski De FEEL-KJ is een instrument dat inzicht biedt in de emotieregulatie van kinderen en jongeren. Kinderen en jongeren vullen in totaal 90 vragen in, waarbij zij aangeven hoe zij omgaan met boosheid, angst en verdriet. Voor elke emotie worden 30 vragen gesteld over wat iemand doet of denkt als hij/zij boos, bang of verdrietig is. De FEEL-KJ geeft scores voor 15 emotieregulatiestrategieën, die worden onderverdeeld in drie categorieën: adaptieve strategieën, maladaptieve strategieën en externe regulatiestrategieën:
Optimization of Rainwater Harvesting Sites using GIS

Water scarcity is hitting new peaks every day and is exacerbated by the current rapid climatic change. Demand for clean water in India is very high, especially for agriculture and consumption. One way to cater to these needs is through rainwater harvesting. Through this paper, we propose a framework that optimizes the site selection for reservoirs by intersecting various data points. Our framework uses a three-step approach to combine stream networks, digital elevation, and soil quality to produce the most viable reservoir sites. Our framework is easy to implement and highly scalable. For the purpose of this paper and a proof of concept, we restrict our focus to the arid Beed district in the state of Maharashtra, India. Our approach provides consistent results that are corroborated by the manual inferences that can be drawn from the data under consideration.
Conference Workshop Paper: Teaching in Research - an Overlooked Practice?

The importance of research-oriented teaching is well-documented in the HE literature but the need for teaching within research is rarely commented upon. This conference paper looked at how much teaching can be used to help embed research skills in undergraduate students and beyond. The paper explored this by considering the design of a research skills workshop presented to Level 2 undergraduates prior to embarking on their final year project work. Analysis of the design offered the opportunity to contest that the amount of teaching that takes place ‘within research’ is very often overlooked. From the first attempts to embed research skills to undergraduates, through to the training of postgraduate students and post-doctoral staff, a constant thread of teaching and learning is apparent within the research environment. The design of the Level 2 workshop gave the opportunity for staff to focus on the desired goals of embedding research skills in students. Such goals included development of self-directed learning, independence, criticality, sense of research identity and a love of lifelong learning.
Benefits and Harms of Testosterone Replacement Therapy in Hypogonadal Men: A Systematic Review and Network Meta-analysis

ii EXECUTIVE SUMMARY . iii ACKNOWLEDGEMENTS . v TABLE OF CONTENTS . vi TABLE OF TABLES . x TABLE OF FIGURES . xv CHAPTER 1: INTRODUCTION . 1 1.1 RATIONALE . 1 1.2 WHY IS A REVIEW NEEDED NOW? 2 1.3 OBJECTIVES . 2 1.4 RESEARCH QUESTIONS . 2 1.5 OUTLINE . 2 1.6 REFERENCES . 3 CHAPTER 2: BACKGROUND . 4 2.1 HYPOGONADISM . 4 2.2 DIAGNOSIS OF HYPOGONADISM . 5 2.3 EPIDEMIOLOGY . 6 2.4 TESTOSTERONE REPLACEMENT THERAPY . 8 2.5 CLINICAL PRACTICE GUIDELINES. 9 2.6 WHAT IS CURRENTLY KNOWN . 10 2.6. 1 BENEFITS . 10 2.6. 2 HARMS . 11 2.7 WHY IS A REVIEW NEEDED NOW? 14 2.8 REFERENCES . 15 CHAPTER 3: BENEFITS OF TESOSTERONE REPLACEMENT THERAPY AMONG HYPOGONADAL MEN . 19 3.
The role of gadoxetic acid-enhanced magnetic resonance cholangiography in the evaluation of postoperative bile duct injury: pictorial essay

Iatrogenic lesion of the bile ducts is a relatively common occurrence during liver surgery, increasing morbidity and mortality rates. T2-weighted magnetic resonance cholangiography and gadoxetic acid-enhanced functional magnetic resonance cholangiography (fMRC) with administration of hepatobiliary-specific contrast medium (gadoxetic acid) are fundamental to the diagnostic imaging approach in patients with such lesions. Here, we present a review of the literature and suggest an imaging approach to biliary tract injury, focusing on clinical cases in which fMRC had an impact on the decision-making process for the management of the affected patients.
Hormone sensitive lipase inhibition by selected medicinal plants

In the present study, 29 medicinal plants belonging to 20 families were evaluated for their hormone sensitive lipase (HSL) inhibitory potential. The methanolic extracts prepared from plant parts used, were tested in vitro at 200 µg/ml concentrations for their inhibitory potential (expressed as % inhibition of XO activity). Twelve plants were found most active (% inhibition more than 30%) and their inhibition profiles (dose-dependent) were further evaluated by estimating the IC50 values of their corresponding extracts. These active plants are Malva nicaeensis All. (IC50 = 51.07 µg/ml), Haplophyllum buxbaumii (Poir.) G. Don. (101.3 µg/ml), Anchusa italica Retz. (132.8 µg/ml), Cleome africana Botsch. (168.9 µg/ml),Salvia fruticosa Mill. (276.7 µg/ml), Glaucium aleppicum Boiss. and Hausskn. ex Boiss. (289.7 µg/ml), Reseda alba L. (396.6 µg/ml), Mentha spicata L. (421.3 µg/ml), Ononis natrixL. (422.8 µg/ml), Chrysanthemum coronarium L. (463.7 µg/ml), Anagallis arvensis L. (751.9 µg/ml), and Hypericum triquetrifolium Turra (828.6 µg/ml). The extracts of the majority of other tested plants showed, however, moderate to weak activities. The results of the present screening provide good herbal choices to combat insulin resistance in human, thus playing a role in developing successful herbal remedies for diabetes and related disorders. Key words: Diabetes mellitus, obesity, hormone sensitive lipase, anti-lipase activity, medicinal plants, plant extracts.
Acceleration of Bone Fracture Healing through the Use of Natural Bovine Hydroxyapatite Implant on Bone Defect Animal Model

Bone is an important organ for supports the body that stores reserve of calcium, phosphorus, and other minerals. In fracture conditions where bleeding, soft tissue edema, nerve damage, and blood vessels around the bone damage happen, they can cause the mobilization of these minerals in the surrounding tissue. One of the efforts made in the treatment of these fractures is reconnection, in which it works by filling of bone defect with a matrix and administration of anti-infection. Biomaterial filling in defective bone is thought to accelerate the healing process of bone fracture and prevent osteomyelitis. For this reason, this study evaluates the acceleration of bone fracture healing using natural hydroxyapatite (NHA) bone filler in rabbits with bone defect model. Fracture modeling was performed by surgical technique and drilling of bones with a 4.2 mm diameter to form a defect in the rabbit femur. Bone implant contained bovine hydroxyapatite-gelatin-glutaraldehyde (BHA implant) or bovine hydroxyapatite-gelatin-glutaraldehyde-gentamicin (BHA-GEN implant) that was inserted in bone defects. 27 rabbits were divided into 3 groups: the control group who had bone defect, the bone defect group was given BHA implant and the bone defect group was given BHA-GEN implant. Observation of osteoclast, osteoblast, osteocyte, BALP level, and bone morphological integrity was carried out on the 14th, 28th, and 42nd days after surgery. Histological observation of rabbit femur showed a significant difference on the number of osteoclast, osteoblast and osteocyte in all three groups. The BALP level also showed a significant difference in the group given the natural BHA bone implant compared to the control group on day 14 (p = 0.0361). Based on the result of the X-ray, there was also a better integration of rabbit femur bone in groups with the use of BHA or BHA-GEN bone implant. Thus, it can be concluded that the use of a natural BHA implant can accelerate the process of bone repair in the fracture of rabbit femur. In addition, BHA implants were compatible as a matrix for supporting the bone cell growth.
The Clinical and Histopathological Characteristics of Cutaneous Malignant Melanoma

Objectives: The most effective method of treatment of cutaneous malignant melanoma (CMM) is surgical excision performed in the early stages. Our aim was to evaluate the descriptive characteristics of CMM. Patients and Methods: Fifty-five patients with malignant melanoma (32 males, 23 females; mean age 50.9aplusmn;12.9; years, range 26 to 76 years) were evaluated retrospectively. Surgical excision alone was performed on stage I and II patients. Regional lymph-node dissection was performed together with surgical excision on patients with palpabl lymph nodes (stages III and IV) detected during preoperative examination. Descriptive characteristics such as anatomical locations, histological subtypes and stages of the CMM were examined; the tumor size and thickness, adjuvant chemotherapy and immunotherapy rates, local recurrence rates were evaluated. Results: Palpabl lymph nodes were identified in 74% (n=41) of the patients. Lymph-node dissection was performed together with surgical excision on these patients. The average tumor thickness and tumor size were 2.1aplusmn;1.3 mm and 21.7aplusmn;11.6 mm respectively. Conclusion: Width of surgical margins and wide surgical resection with lymph-node dissection for CMM will have no effect on loco-regional recurrence, distant metastases and survival rates. The complications and benefits must be meticulously evaluated before application of lymph-node dissection. Turkish Baslik: Malign Melanomlarin Klinik ve Histopatolojik Ozellikleri Anahtar Kelimeler: Lenf nodu eksizyonu; melanoma/patoloji/cerrahi Amac: Deri malign melanomlarinin en etkili tedavi yontemi erken donemde yapilacak cerrahi eksizyondur. Bu calismada malign melanomun tanimlayici ozelliklerinin saptanmasi amaclandi. Hastalar ve Yontemler: Malign melanom saptanan 55 hastanin (32 erkek, 23 kadin; ort. yas 50.9aplusmn;12.9; dagilim 26-76) dosyalari geriye donuk olarak incelendi. Evre I ve evre II hastalara yalnizca cerrahi eksizyon yapildi. Ameliyat oncesi donemde palpabl lenf nodu tespit edilen evre-III ve evre-IV hastalarda cerrahi eksizyonla birlikte bolgesel lenf nodu diseksiyonu yapildi. Malign melanomlarin yerlesim yerleri, histolojik alt turleri ve evreleri gibi tanimlayici ozellikleri incelendi; tumor capi ve derinligi, yardimci kemoterapi ve immunoterapi oranlari, lokal yineleme oranlari degerlendirildi. Bulgular: Kirk bir hastada (%74) palpabl lenf nodu tespit edildi. Bu hastalara cerrahi eksizyonla birlikte bolgesel lenf nodu diseksiyonu yapildi. Ortalama tumor capi 21.7aplusmn;11.6 mm, tumor derinligi ise 2.1aplusmn;1.3 mm bulundu. Sonuc: Cerrahi sinirlarin genisligi ve lenf nodu diseksiyonu ile lokal yineleme, uzak metastazlar ve yasam suresi arasinda anlamli bir iliski olmadigi saptandi. Bolgesel lenf nodu diseksiyonu yapmaya karar verirken diseksiyondan beklenen yararlar ve olasi komplikasyonlar goz onunde bulundurularak karar verilmelidir.
Development and validation of a novel diagnostic model for assessing lung cancer metastasis in a Chinese population based on multicenter real-world data

Background Accurate disease staging plays an important role in lung cancer's clinical management. However, due to the limitation of the CT scan, it is still an unmet medical need in practice. In the present study, we attempted to develop diagnostic models based on biomarkers and clinical parameters for assessing lung cancer metastasis. Methods This study consisted of 799 patients with pulmonary lesions from three regional centers in China. It included 274 benign lesions patients, 326 primary lung cancer patients without metastasis, and 199 advanced lung cancer patients with lymph node or organ metastasis. The patients were divided into nodules group and masses group according to tumor size. Results Four nomogram models based on patient characteristics and tumor biomarkers were developed and evaluated for patients with nodules and masses, respectively. In patients with pulmonary nodules, the AUC to identify metastatic lung cancer from unidentified nodules (including benign nodules and lung cancer, model 1) reached 0.859 (0.827–0.887, 95% CI). Model 2 was used to predict metastasis in patients with lung cancer with AUC of 0.838 (0.795–0.876, 95% CI). In patients with pulmonary masses, the AUC to identify metastatic lung cancer from unidentified masses (model 3) reached 0.773 (0.717–0.823, 95% CI). Model 4 was used to predict metastasis in patients with lung cancer and AUC reached 0.731 (0.771–0.793, 95% CI). Decision curve analysis corroborated good clinical applicability of the nomograms in predicting metastasis. Conclusion All new models demonstrated promising discrimination, allowing for estimating the risk of lymph node or organ metastasis of lung cancer. Such integration of blood biomarker testing with CT imaging results will be an efficient and effective approach to benefit the accurate staging and treatment of lung cancer.
Evidence brief - How large pictorial health warnings on the packaging of tobacco products affect knowledge and behaviour

Evidence shows that combined written and graphic health messages on the packaging of tobacco products are more effective than text-only warnings. Indeed, images have been shown to increase the awareness of the health risks related to tobacco consumption. Article 11 of the WHO FCTC requires the adoption of health warnings on packages and the guidelines on implementation of this article recommend the adoption of pictorial health warnings. Studies have shown that pictorial health warnings increase quit attempts and decrease smoking uptake. Pictorial health warnings, including graphic, fear-arousing information, have proven to be particularly effective. They also have public support; half of the EU citizens recognized the effectiveness of such measures in 2008. Contrary to what tobacco companies are claiming, pictorial health warnings are fast and cheap to implement, and they do not increase illicit trade. These measures are in compliance with international trade law and intellectual property law.
Screening of prescriptions in geriatric population in a tertiary care teaching hospital in north India

The objective of our study was to assess the pattern of prescribing prescriptions and cost analysis among the geriatric patients attending the Medicine Outpatient Department of NIMS Medical College and Hospital, Jaipur. After taking permission from the Institutional Ethical Committee, prescriptions of 235 geriatric patients attending the medicine outpatient department of NIMS Medical College and Hospital, Jaipur, were noted and demographic profile, commonly prescribed drugs as per Anatomical Therapeutic Chemical Classification (ATC) and WHO core indicators were assessed after taking written informed consent from the patients. Out of 235 patients, 130(55.31%) were males and 105(44.68%) were females and most of the patients were in the age group of 81-85 for males 65-70 for females. Maximum number of patients were having cardiovascular diseases (n=196) followed by respiratory disorders (n=172) and musculoskeletal diseases (n=153). 89 patients (38%) were having three comorbid conditions. Average number of drugs per prescription was 5.51(1296/235). Drugs on WHO EML were 546 while on NLEM was779. Drugs prescribed by generic names were 31.94%, is less than that prescribed by their brand names 68.05%. Average cost per prescription was INR 18.75 per day. Drugs prescribed as fixed dose combinations were 324. Drugs acting on cardiovascular system (n=356) were the most commonly used drugs in our study followed by antibiotics (n=127) and bronchodilators (n=126). Thus irrational prescribing and polypharmacy were prevalent among elderly.
Automated image interpretation in mammography, cytogenetics and retinopathy

The author describes work which is directed at three areas of medical investigation in which screening of asymptomatic but high-risk cases is carried out. The three applications are rather different medically and work is at different stages of maturity. They exhibit, however, a common approach to screening applications-that of an interactive aid to a trained human assessor. In the author's experience, the diagnostic aid mode of operation can produce genuine advantages in clinical practice, while allowing the accrual of experience in analysis of real images which can be used in making progress towards systems with ever smaller human involvement. An important advantage of this approach is that system development can proceed holistically, making optimal use of human expertise. The example of a mature application in automated image interpretation in cytogenetics is used as a model for this style of development. Mammography and retinopathy provide examples of current work being developed along similar lines. >
A Naturalistic Study of Carbon Monoxide, Heart Rate, Oxygen Saturation, and Perfusion Index in Hookah Lounge Patrons

BACKGROUND: Waterpipe (also known as hookah) smokers are exposed to several toxicants, heavy metals, and carcinogens. This study assessed physiologic data from hookah bar participants in an urban area in Florida. We hypothesized that hookah lounge patrons would have a decreased SpO2 and perfusion index, as well as an increased heart rate and exhaled carbon monoxide (CO) levels upon exiting the bars. METHODS: Exhaled CO levels, heart rate, pulse oximetry for carboxyhemoglobin, and perfusion index were obtained immediately before entering the hookah lounges and after exiting hookah lounges on a sample size of 200 patrons attending hookah lounges. Averages were then used for Wilcoxon signed-rank tests to assess differences across means. RESULTS: Combining data from both hookah smokers and concurrent smokers, the mean CO measurements went from 5.7 ppm prior to lounge entry to 66.5 ppm after the lounge visit (P < .001). Conversion to carboxyhemoglobin for all hookah smokers represents an increase from 1.5% to 10.6% (P < .001). Carboxyhemoglobin mean values as measured with pulse oximetry increased from 1.4% prior to the lounge visit to 7.2% after the lounge visit (P < .001). The mean heart rate for the subjects also increased from 90.3 beats/min to 94.2 beats/min (P < .001). SpO2 levels decreased from 98.4% to 97.8% (P < .001). Similarly, the mean perfusion index decreased from 3.1% to 2.7% (P = .002). CONCLUSIONS: Hookah lounge smokers in the United States are exposed to high levels of CO that have the potential for detrimental health effects, as evidenced by rapid negative changes in physiological parameters. Respiratory therapists should be aware of potential cardiovascular changes in hookah lounge patrons who enter emergency rooms and health facilities due to recent exposures.
A Case of Psoriasis Complicated with Systemic Lupus Erythematosus

Observations: Psoriasis is a chronic, inflammatory skin disease. Autoimmune diseases such as Hashimato thyroiditis, autoimmune hemolytic anemia and Sjogren syndrome have been reported to accompany psoriasis. However, association of “psoriasis and systemic lupus erythematosus” is very rare. Here, we report a 45-year-old woman with psoriasis vulgaris complicated with systemic lupus erythematosus.