Miracle-dz/UniFAR-FTUs huggingface dataset:
Absorptive capacity in child welfare: a qualitative study with child welfare staff eliciting key factors for evidence-based practice adoption

ABSTRACT Child Welfare (CW) provides an array of services to meet the needs of families, requiring agencies to be malleable in their ability to absorb new practices. Absorptive capacity (ACAP) refers to the routines and processes in which an organization acquires, assimilates, and applies new knowledge. ACAP has yet to be the focus of implementation research in CW settings. This exploratory study elicited feedback from CW staff in determining factors to consider when absorbing a new practice. Themes of logistic support, agency culture, and feedback from families emerged. Findings offer insights for CW agencies to consider when adopting a new practice.
Investigation of molar concentration effect on structural, optical, electrical, and photovoltaic properties of spray‐coated Cu2O thin films

High quality copper oxide thin films were prepared by nebulizer spray pyrolysis technique using different concentrations of copper precursor solution. Concentration‐dependent structural, morphological, optical, and electrical properties of the prepared films are discussed. X‐ray diffraction studies done for the samples confirmed that the deposited films are in Cu2O phase with polycrystalline cubic structure. Atomic force microscopy analysis revealed that all the films are composed of nano sheet shaped grains covering the substrate surface. Optical studies done on the samples showed band gap values 2.42, 2.31, and 2.02 eV for the solution concentration 0.01, 0.05, and 0.1 M, respectively. Photoluminescence spectral analysis showed the emission band at 620 nm confirming the formation of cuprous oxide. Electrical analysis of the films showed p‐type conductivity with a low resistivity 2.19 × 102 Ω. cm and high carrier concentration 16.76 × 10 15 cm−3 for the molar concentration 0.1 M. In this work, Cu2O/ZnO heterojunctions were also prepared, and solar cell properties were studied; they were found to show increased open circuit voltage and short circuit current for higher copper concentration.
Paediatric Intensive Care Staff Experiences of Debriefing Post Critical Incident; a Qualitative Study of the Leeds ‘time Out’ Method

BackgroundHow intensive care teams respond to critical incidents is important for maintaining effective patient care, staff education and morale(1). We investigated Paediatric Intensive Care (PIC) staff experiences of participating in novel 20 minute group ‘time outs’ held after critical incidents.MethodA qualitative study using semi-structured interviews with staff attendees of ‘time outs’. Interviews transcribed and analysed using thematic analysis. Results shared with interviewees for participant validation. Ethical approval granted by the University of Leeds School of Medicine Research Ethics Committee (approval number SOMREC17-020). Results8 semi-structured interviews lasted on average 45 minutes each. Participant roles; 1 Consultant, 1 PIC grid trainee, ST3 Paediatrician, 1 Advanced Nurse Practitioner, 2 Band 6 Nurses and 2 Band 7 Nurses. Thematic analysis generated 1,060 initial codes, subsequently revised until a thematic map emerged, containing five main themes: 1. Context and culture in which critical incidents and ‘time outs’ are embedded, including hierarchy and local politics.2. Pragmatics of organising and evaluating ‘time outs’. 3. Position of valued clinical psychologists, who were removed from the ‘time outs’. 4. Reflections on coping and resilience, notably blame and fear.5. Process of attending a time out and its impact – both positive (clinical knowledge and the ability to cope) and negative (damaging if inappropriately run). ConclusionThe data contextualised the time outs within the complex PIC environment, with politics, communication challenges and hierarchies affecting how staff respond and how they are supported following critical incidents. Though practical challenges of time outs were noted, this intervention has potential to improve the understanding and well-being of PIC staff after critical incidents.
Qualitative Acceptance Model of Augmented Reality from the Perspective of Personalists

Smart devices and the corresponding new technologies have established themselves within our society. Since the release of the smartphone game Pokémon Go, the field of augmented reality (AR) - the enrichment of reality with information, realized by smart devices such as tablets, data glasses or smartphones - has been experiencing an upswing. Additionally, the industry is starting to integrate AR applications to increase efficiency. In this respect, HR managers play a key role in the implementation of such technology. They maintain direct contact with employees, have an overview of the entire company and thus are often responsible for change processes. The paper analyses the potential of AR within a company from a personalist’s point of view and discusses critical factors both in theory and practice. The paper validates the technological possibilities and shows results from a qualitative analysis from focus group discussions. The qualitative acceptance model displays factors influencing the implementation of AR.
Clinical presentations and long-term prognosis of childhood-onset polyarteritis nodosa in a single centre: a retrospective study

Background: Polyarteritis nodosa (PAN) is a systematic necrotizing vasculitis involving medium-sized arteries. Childhood-onset PAN ranges from mild to severe systematic disease causing damage and early mortality. As it is a rare disease in children, there is less study on clinical features, diagnosis and treatment than adults. And diagnosis occurs relatively late in most paediatric patients with polyarteritis nodosa. Therefore, this study aimed to investigate clinical manifestations, laboratory findings, treatment strategies, and long-term outcomes among patients with childhood-onset polyarteritis nodosa treated at a single-centre in Korea. We further aimed to evaluate the usefulness of the Birmingham Vasculitis Activity Score (BVAS) and Five-Factor Score (FFS) in paediatric patients.Methods: We retrospectively analysed data collected from patients with childhood-onset PAN treated at our institution from March 2003 to February 2020. Results: Nine patients (6 male and 3 female) were included in the study. The median ages at symptom onset and diagnosis were 7.6 (3–17.5) and 7.7 (3.5–17.6) years, respectively. The median follow-up duration was 7.0 (1.6–16.3) years. Eight patients were diagnosed with systemic PAN, while one was diagnosed with cutaneous PAN. All patients exhibited skin manifestations, while five exhibited Raynaud’s phenomenon. Organ involvement was observed in one patient. Constitutional symptoms such as fever, arthralgia, myalgia, and weight loss were also observed. Antineutrophil cytoplasmic antibodies were absent in all patients. The median BVAS at diagnosis was 8 (range: 2–29), and one patient had an FFS of 1. Prednisolone was initially used for induction in all patients, and other drugs were added in cases refractory to prednisolone. All patients survived despite some complications such as intracranial haemorrhage or digital necrosis requiring amputation.Conclusions: Early diagnosis and treatment may minimise sequelae in patients with childhood-onset PAN. Further multicentre studies are required to clarify the unique characteristics of childhood-onset PAN and establish treatment guidelines, early detection strategies, and biomarkers. Trial registration: Retrospectively registered.
Efficient Method for Data Deduplication over Encrypted Data in Cloud

—This project allows the user to identify the duplication of files in the cloud. When a user uploads a file, the software implemented on the system will ask the user for checking duplication. If the file already exists, which will be shared with the user’s cloud storage by making a secure side channel. So no need to upload the file to the cloud and it will save them time and space. But there is a security vulnerability in the user file. We use two methods for finding duplication. One is ZEUS, other is ZEUS+. In Zeus, if duplication found the file from the cloud (file of any other)will be shared (side-channel created) without asking permission. So it makes the cloud insecure. Zeus+ creates a side channel with the authentication of the particular user who uploaded the file earlier.
Prediction of metabolite activities by repetitive clustering of the structural similarity based networks

A number of studies have investigated the relations between structures and activities of metabolites. It has been proposed that structural similarity between metabolites implies activity similarity between them. In light of this fact we propose a method for activity prediction of secondary metabolites based on association philosophy. First we determined the structural similarity scores between targeted metabolite pairs using COMPLIG algorithm. To increase the possibility of clusters rich with known metabolites we calculated structural similarity between metabolite pairs for which activities of both or at least one metabolite is known and then selected the metabolite pairs for which the similarity score is higher than a threshold ( s > 0.95). The network of such metabolite pairs was then clustered using the DPClusO algorithm. Statistically significant cluster-activity pairs were then selected using the hypergeometric test. Then biological activities of unannotated metabolites were predicted from the activity of metabolites included in the statistically overrepresented clusters.
Arabidopsis ribosomal proteins RPL23aA and RPL23aB are functionally equivalent

Background: In plants, each ribosomal protein (RP) is encoded by a small gene family but it is largely unknown whether the family members are functionally diversified. There are two RPL23a paralogues genes ( RPL23aA and RPL23aB ) found in Arabidopsis thaliana . Knock-down of RPL23aA using RNAi impeded growth and led to morphological abnormalities, whereas knock-out of RPL23aB had no observable phenotype, thus these two RPL23a paralogous proteins have been used as examples of ribosomal protein paralogues with functional divergence in many published papers. Results: In this study, we characterized T-DNA insertion mutants of RPL23aA and RPL23aB . A rare non-allelic non-complementation phenomenon was found in the F1 progeny of the rpl23aa X rpl23ab cross, which revealed a dosage effect of these two genes. Both of RPL23aA and RPL23aB were found to be expressed almost in all examined tissues as revealed by GUS reporter analysis. Expression of RPL23aB driven by the RPL23aA promoter can rescue the phenotype of rpl23aa , indicating these two proteins are actually equivalent in function. Interestingly, based on the publicly available RNA-seq data, we found that these two RPL23a paralogues were expressed in a concerted manner and the expression level of RPL23aA was much higher than that of RPL23aB at different developmental stages and in different tissues. Conclusions: Our findings suggest that RPL23aA and RPL23aB proteins actually have equal function and presence of paralogous genes for the RPL23a protein in plants might be necessary to maintain its adequate dosage. as exemplified by the single mutant phenotypes. Our findings suggest that the two paralogous RPL23a proteins had equivalent function and the presence of multiple genes for individual RPs in plants might be necessary to maintain adequate ribosome dosage at least for some ribosomal protein families. paralogues with functional divergence in many published papers. In this study, our findings provided four convincing evidences demonstrating duplicated RPL23a genes actually have redundant function (without functional specialization), thus are necessary to provide a threshold dose: 1) The non-allelic non-complementation phenomenon between rpl23aa and rpl23ab suggests RPL23aA and RPL23aB are dosage dependent genes; 2) RPL23aA and RPL23aB genes are expressed in the same tissues; 3) RPL23aB could rescue the phenotype of rpl23aa, demonstrating RPL23aA and RPL23aB protein have equal function; 4) RPL23aA and RPL23aB genes are transcribed in a concerted manner without spatiotemporal divergence. Since the presence of multiple genes for individual RP widely exists in plants, our findings will have implications to study other paralogous RP genes.
Study on rosmarinic acid separation by synergic extraction

ABSTRACT Separation of rosmarinic acid by synergic reactive extraction using a mixture of two extractants (one of aminic and one of basic type) dissolved in solvents with different polarities has been studied. By analysing the influences of the main factors (organic phase polarity, extractant concentration in the mixture) on the synergic effect, the most important synergic effect (CS = 10.89) was found to correspond to the extractants mixture containing 5 g/l D2EHPA and 5 g/l Amberlite LA-2 dissolved in n-heptane. In this system the extraction constant reached the maximum value of 6.78 l2/mol2.
Approches micro/milli-fluidiques pour l'étude in situ de procédés de filtration frontale

Ce travail de these porte sur le developpement technologique d’outils miniaturises micro- (10 µm) et milli- (1 mm) fluidique, pour l’etude in situ de procedes de filtration frontale, en collaboration avec l’entreprise Solvay. Les outils developpes permettent le suivi visuel de la formation de gâteaux de filtration en operant des essais a pression ou a debit constant sur diverses suspensions colloidales, jusqu’a des pressions trans-membranaires de l’ordre de 7 bars.L’etude millifluidique de la filtration de dispersions industrielles de silice colloidale (Solvay, Silica), a permis de mettre en evidence la croissance de gâteaux compressibles et de correler ces donnees aux signaux de pression, obtenus a debit impose. Ces memes donnees sont confrontees aux lois classiques de la filtration (« cake filtration theory »), mettant en evidence que les modelisations classiques ne peuvent pas reproduire les comportements observes.La seconde partie de la these porte sur le developpement d’un outil microfluidique, integrant des membranes hydrogel nano-poreuses, pouvant resister a de fortes pressions (quelques bars). Ces membranes sont fabriquees in-situ par photo-polymerisation de formulations aqueuses contenant des PEG-diacrylates et des agents porogenes. Notre travail a permis une caracterisation precise de leur permeabilite en fonction de divers parametres (formulation, temps d’exposition, geometrie). Ces memes membranes ont ete utilisees pour suivre la filtration frontale de nanoparticules aux echelles microfluidiques, et ainsi estimer quantitativement la permeabilite des gâteaux formes.
Power Loss of Crystalline Solar Cell under Cyclic Loadings

In application of building attached photovoltaic in China, the solar cells in the modules are mono-crystalline or polycrystalline cells. In some applications where the wind load is at higher level, a large deflection of the modules will occur. Due to the fluctuation of the wind load, the initial damages inside the cells will develop under this cyclic loading, as a result, the power loss of the solar cell can be observed due to the development of the fatigue damage. In this paper, the fatigue damage evolution of crystalline solar cell in module is investigated experimentally. The damage evolution with the cyclic number was obtained via the measurement of the power loss of the cell. The damage evolution equation was derived based on the continuum damage mechanics and the fatigue life of the cell was predicted.
TRI-E® PREVENTS COGNITIVE IMPAIRMENT AND DEOXYRIBONUCLEIC ACID DAMAGE IN DIABETES MELLITUS

Objective: The aim of the current study is to compare the difference of Tri-E® and ATF potentials in reducing diabetic adverse event due to hyperglycemia that might cause the DNA damage and cognitive impairment indirectly. Methods: Diabetic model sample from Sprague Dawley was developed by combination of twice low-dose streptozotocin injection and high fat diet. The diabetic rat model was treated with Tri-E® and ATF in different groups, control group were provided. The DNA was collected from the whole blood and DNA damage was measured using the comet assay method. While cognitive status was measured using Morris water-maze method. Result: Reduction of the DNA damage and improvement of cognitive function were observed in both ATF and Tri-E® supplementations that elevated in diabetic. However, the DNA damage reduction by Tri-E® was one-fold higher compared to ATF supplementation. Conclusion: This study provided data that Tri-E® has superior potential than ATF as a preventative agent to DNA damage and cognitive impairment in diabetes indirectly.
Verification of precision, accuracy, and characteristics of dual-energy X-ray absorptiometry and nuclear magnetic resonance in the analysis of mouse body composition

Background: As an instrument for measuring body composition in experimental animals, dual-energy X-ray absorptiometry (DXA) is ideal for accuracy, cost, and measurement efficiency. However, there is too little insight into the effectiveness of the various aspects of applying DXA to experimental animals. Therefore, we investigated whether to compare and verify the precision and accuracy of DXA and nuclear magnetic resonance (NMR) animal body composition analyzers. We used 30 ICR mice in the study. First, in order to evaluate the reproducibility of DXA and NMR, we did repeated measurements by repositioning each mouse in anesthesia and euthanasia states. Subsequently, the accuracy of each device was evaluated by comparing the weight measured before the experiment, the weight of the tissue extracted from the mice after the experiment, and the measured DXA and NMR. In addition, when measuring the body composition of animals, we compared the time and the measurable body composition parameters and summarized the advantages and disadvantages of the two devices.Results: Compared to NMR, DXA had the advantage of a fast measurement of bone composition and rapid image analysis. In addition, DXA showed a higher correlation (> 95%) with FM, body weight, and fBMC baseline than did NMR (> 85%). Conclusion: In conclusion, DXA was confirmed to have higher precision and measurement accuracy than did NMR. Therefore, DXA is an effective method for evaluating the body composition of experimental animals.
Estimation of calcium, potassium and sodium contents in commonlyconsumed food of Karnataka coastal belt region, India

Minerals are essential elements of the human diet, aiding in cellular body processes from rebuilding tissue to maintaining ion gradients. Hence this report presents a comparative study of the determination of calcium, potassium and sodium in a wide variety of food used in coastal belt of Karnataka, India. Studies are carried out on vegetables, grains, pulses, fishes, egg, meat, etc to estimate the concentration of various minerals in them. Calcium found to be the most abundant in Omum (1313.84mg/100g), potassium in Jeerige/Cumin (1047.91mg/100g) and sodium in Shell fish (436.24mg/100g). The results showed that the all food stuffs have safe and adequate dietary nutrients if consumed in right proportion. Present work to determine mineral is based on flame photometry and it is very simple, inexpensive and less time consuming
Bosentan loaded Microemulsion: A novel formulation and evaluation of their in-vitro and in-vivo characteristic

The main objective of the research work was to improve the solubility of Bosentan by preparing Microemulsion (ME) for pulmonary artery hypertension therapy. Capmul MCM C8 was selected as oil, Tween 20 as a surfactant and Transcutol HP as a co-surfactant. From Pseudoternary phase diagram ratio of Smix (1:1) selected. From the Microemulsion area of ternary diagram different batches were prepared, but the drug was precipitate from the formulation which can be avoid by adding precipitate inhibitor. Pluronic F 127 was utilized as precipitate inhibitor in the concentration of 1.5%. The optimized formulation ME 8 contain oil (30 %V/V), Smix (60 %V/V) and water (10 %V/V). The prepared Microemulsion evaluated for globule size 96.71±0.11 nm, % transmittance 99.45±0.54 % and >99 % drug content. TEM confirm the spherical shape of globule. The physicochemical parameter of ME 8 was performed and to enhance the stability of Microemulsion it is converted in to solid ME by using adsorbent. Aeroperl 300 was selected as an adsorbent in the drug to adsorbent ratio (1:0.5 %W/W) based on physicochemical properties. From the in-vitro drug release investigation after 7 hours %CDR of ME 8 was found to be 78.87±0.17% and solid Microemulsion (SME 3) shows 76.83±0.29%. The pure drug shows only 27.63±0.23% CDR, which indicate that ME revealed better drug release than pure drug. There was a 2.8 fold increases in solubility compare to pure drug. From the In-vivo data compared to convention formulation, there was significant change in pharmacokinetics data observed.
The Effects of Nanoscale Zerovalent Iron on Microbial Fuel Cells in the Start‐up Process

Municipal sludge contains carbon‐rich material that can be used in microbial fuel cells (MFCs) to generate electrical power. However, manufactured nanoparticles found in sewage pose a potential risk in MFCs although the extent of this is still unclear. In this study, MFCs using sludge containing two types of nanoscale zerovalent iron (nZVI) as substrates are investigated. It is found that in the MFC start‐up process, the maximum output voltage of the green synthesized nZVI (g‐nZVI) group and chemically synthesized nZVI group (c‐nZVI) decreases to 202.5 mV and 94.7 mV, respectively. Meanwhile the maximum output voltage of the control group is higher than 500 mV. These outcomes are attributed to a high concentration of nZVI being inhibited during the start‐up phase, and nZVI makes no essentially significant change in generating electricity despite MFCs being started successfully. Concerning the results on the rate of removing chemical oxygen demand, scanning electron microscope, and electrochemical characterization indicate that green synthesized nZVI, compared to chemically synthesized nZVI, reveals less antibacterial activity to microbial community in anode. The electronic properties of MFCs are lightly affected due to the mature biofilm adhering to the anode's electrode surface. Finally, nZVI can effectively extend and stabilize the output voltage of the produced electricity by releasing Fe3+ ions.
Stability-indicating Reversed Phase-Ultra Performance Liquid Chromatography Method Development and Validation for Simultaneous Determination of Encorafenib and Binimetinib in Formulation

A simple, accurate and precise stability indicating method was developed for the simultaneous estimation of the encorafenib (ECRB) and binimetinib (BMTB) in a dosage form by UPLC. Chromatographic elution was processed through a HSS C18 (100 x 2.1 mm, 1.8m) reverse phase column and the mobile phase composition of 0.01N KH2PO4 buffer (3.5 pH) and acetonitrile in the proportion of 55:45 was processed thru a column at a flow rate of 1.0 ml/min. Temperature of the column oven was kept at 30.0°C and the wavelength maximum of detection system was set to 294 nm. Retention times of ECRB and BMTB were found to be 0.767 min and 1.130 min respectively. Repeatability of the method was determined in the form of %RSD and findings were 0.3 and 0.6 for ECRB and BMTB respectively. The percentage recovery of the method was found to be 99.59% and 99.70% for ECRB and BMTB respectively. LOD, LOQ values obtained from regression equations of ECRB and BMTB were 0.51, 1.55mg/ml and 1.47, 4.44 mg/ml respectively. Regression equation of ECRB was y = 6684.x + 18102 and BMTB was y = 13118x + 2159. Two analytes were subjected for acid, peroxide, photolytic, alkali, neutral and thermal degradation studies and the results shown that the percentage of degradation was found between 0.76% and 6.88%. Retention times and total run time of two drugs were decreased and the developed method was simple and economical. So, the developed method can be adopted in industries as a regular quality control test for the quantification of ECRB and BMTB.