Miracle-dz/UniFAR-FTUs huggingface dataset:
Genetic Erosion: No Longer Just an Agricultural Issue

Genetic considerations pertaining to planting projects usually emphasize locally adapted source material. However, the amount of genetic diversity in the plant materials is important as well. Genetic erosion is the loss of genetic diversity—often magnified or accelerated by human activities. In native plant populations, genetic erosion results from habitat loss and fragmentation, but it also can result from a narrow genetic base in the original collections or by practices that reduce genetic diversity. Although species-specific guidelines are not available, managers can minimize the risk of genetic erosion by being familiar with the biology of the affected species (including breeding system, mode of reproduction, and pattern of genetic diversity). Narrowly based genetic collections should be avoided, providers of plant materials for revegetation projects should offer information on their collection methods, and nursery managers should endeavor to minimize diversity losses at all stages of nursery culture.
Size Distribution, Mechanical and Electrical Properties of CuO Nanowires Grown by Modified Thermal Oxidation Methods

Size distribution, Young’s moduli and electrical resistivity are investigated for CuO nanowires synthesized by different thermal oxidation methods. Oxidation in dry and wet air were applied for synthesis both with and without an external electrical field. An increased yield of high aspect ratio nanowires with diameters below 100 nm is achieved by combining applied electric field and growth conditions with additional water vapour at the first stage of synthesis. Young’s moduli determined from resonance and bending experiments show similar diameter dependencies and increase above 200 GPa for nanowires with diameters narrower than 50 nm. The nanowires synthesized by simple thermal oxidation possess electrical resistivities about one order of magnitude lower than the nanowires synthesized by electric field assisted approach in wet air. The high aspect ratio, mechanical strength and robust electrical properties suggest CuO nanowires as promising candidates for NEMS actuators.
Zinc Oxide Nanoparticles Damage Tobacco BY-2 Cells by Oxidative Stress Followed by Processes of Autophagy and Programmed Cell Death

Nanomaterials, including zinc oxide nanoparticles (ZnO NPs), have a great application potential in many fields, such as medicine, the textile industry, electronics, and cosmetics. Their impact on the environment must be carefully investigated and specified due to their wide range of application. However, the amount of data on possible negative effects of ZnO NPs on plants at the cellular level are still insufficient. Thus, we focused on the effect of ZnO NPs on tobacco BY-2 cells, i.e., a widely accepted plant cell model. Adverse effects of ZnO NPs on both growth and biochemical parameters were observed. In addition, reactive oxygen and nitrogen species visualizations confirmed that ZnO NPs may induce oxidative stress. All these changes were associated with the lipid peroxidation and changes in the plasma membrane integrity, which together with endoplasmatic reticulum and mitochondrial dysfunction led to autophagy and programmed cell death. The present study demonstrates that the phytotoxic effect of ZnO NPs on the BY-2 cells is very complex and needs further investigation.
Interaction and Reactivity of Cisplatin Physisorbed on Graphene Oxide Nano-Prototypes

The physical adsorption of cisplatin (CP) on graphene oxide (GO) and reduced graphene oxide (rGO) is investigated at the DFT level of theory by exploiting suitable molecular prototypes representing the most probable adsorbing regions of GO and rGO nano-structures. The results show that the CP binding energy is enhanced with respect to that for the interaction with pristine graphene. This is due to the preferential adsorption of the drug in correspondence of the epoxy and hydroxy groups located on GO basal plane: an energy decomposition analysis of the corresponding binding energy reveals that the most attractive contribution comes from the electrostatic attraction between the -NH3 ends of CP and the oxygen groups on (r)GO, which can be associated with hydrogen bonding effects. Moreover, it is found that the reactivity of the physically adsorbed CP is practically unaltered being the free energy variation of the first hydrolysis reaction almost matching that of its free (unadsorbed drug) counterpart. The reported results suggest that the CP physical adsorption on GO and rGO carriers is overall feasible being an exergonic process in aqueous solution. The CP adsorption could facilitate its solubility and transport in water solutions, exploiting the high hydrophilicity of the peripheral carboxylic groups located on the edge of the GO and rGO nano-structures. Moreover, the the higher affinity of CP with respect to the oxidized sites suggests a possible dependence of drug loading and release on pH conditions, which would highly facilitate its specific delivery.
On the Feasibility of Fan-Out Wafer-Level Packaging of Capacitive Micromachined Ultrasound Transducers (CMUT) by Using Inkjet-Printed Redistribution Layers

Fan-out wafer-level packaging (FOWLP) is an interesting platform for Microelectromechanical systems (MEMS) sensor packaging. Employing FOWLP for MEMS sensor packaging has some unique challenges, while some originate merely from the fabrication of redistribution layers (RDL). For instance, it is crucial to protect the delicate structures and fragile membranes during RDL formation. Thus, additive manufacturing (AM) for RDL formation seems to be an auspicious approach, as those challenges are conquered by principle. In this study, by exploiting the benefits of AM, RDLs for fan-out packaging of capacitive micromachined ultrasound transducers (CMUT) were realized via drop-on-demand inkjet printing technology. The long-term reliability of the printed tracks was assessed via temperature cycling tests. The effects of multilayering and implementation of an insulating ramp on the reliability of the conductive tracks were identified. Packaging-induced stresses on CMUT dies were further investigated via laser-Doppler vibrometry (LDV) measurements and the corresponding resonance frequency shift. Conclusively, the bottlenecks of the inkjet-printed RDLs for FOWLP were discussed in detail.
Parsimony analysis and ecological communities, phytosociology, nested subsets analysis, forest fragmentation: a reply to Giannini and Keller

We suggested using parsimony analysis to study community evolution in terms of species composition and to apply these results in the context of forest fragmentation as a replacement for the so‐called “nested subsets analysis” or other phenetic synecological or phytosociological methods ( Pellens et al., 2005 ). Giannini and Keller (2007 ) took issue with this new application on the basis of three misunderstandings. We re‐emphasize that communities themselves are analyzed, not landscape parts such as forest fragments. Therefore, it must be clear that communities are analogous to taxa and landscape parts such as fragments are analogous to distributions of taxa. Community evolution is the change in community composition by immigration, emigration and local extinction. Thus, gains and losses of species should not be confused with horizontal transfer. Parsimony analysis does not necessarily group communities based on shared absences of rare species. Rare species are not necessarily absent in the same communities and these absences are not necessarily inferred to be synapomorphies after rooting. This is the main advance expected when cladistics is used instead of the previously cited phenetic methods working with overall similarity.
Deicing Concrete Pavements and Roads with Carbon Nanotubes (CNTs) as Heating Elements

Existing deicing technologies involving chloride and heating wires have limitations such as reduced durability of roads and surrounding structures, and high labor requirements and maintenance costs. Hence, in this study, we performed indoor experiments, numerical analyses, and field tests to examine the efficiency of deicing using carbon nanotubes (CNTs) to overcome these limitations. For indoor experiments, a CNT was inserted into the center of a concrete sample and then heated to 60 °C while maintaining the ambient and internal temperatures of the sample at −10 °C using a refrigeration chamber. Numerical analysis considering thermal conductivity was performed based on the indoor experimental results. Using the calculation results, field tests were conducted, and the thermal conduction performance of the heating element was examined. Results showed that the surface temperature between the heating elements exceeded 0 °C. Moreover, we found that the effective heating distance of the heating elements should be 20–30 cm for effective thermal overlap through the indoor experiments. Additionally, the numerical analysis results indicated that the effective heating distance increased to 100 cm when the heating element temperature and experiment time were increased. Field test results showed that 62 cm-deep snow melted between the heating elements (100 cm), thus, verifying the possibility of deicing.
HRT assessment reviewed: a systematic review of heart rate turbulence methodology

Heart rate turbulence (HRT) is a biphasic reaction to a ventricular premature contraction (VPC) mainly mediated by the baroreflex. It can be used for risk stratification in different disease patterns. Despite existing standards there is a lot of variation in terms of measuring and calculating HRT, which complicates research and application. Objective: This systematic review outlines and evaluates the methodological spectrum of HRT research, especially filtering criteria, parameter calculation and thresholds. Approach: The analysis includes all research papers written in English that have been published before 12.10. 2018, are listed on PubMed and involve calculation of HRT parameter values. Main results: HRT assessment is still being performed in various ways and important specifications of the methodology are not given in many articles. Nevertheless, some suggestions regarding HRT methodology can be made: a normalised turbulence slope should be used to uncouple the parameter from heart rate and frequency of extrasystoles. Filtering criteria as formerly reviewed in the guidelines should be met and mentioned. The minimal number of VPC snippets (VPCSs) as well as new cut-off values for different risks need to be further evaluated. Most importantly, the exact and complete methodology must be described to ensure reproducibility and comparability. Significance: Methodical variation hinders comparability of research and medical application. Our continuing questions help to further standardise the measurement and calculation of HRT and increase its value for medical risk stratification.
Flame Retardant Submicron Particles via Surfactant-Free RAFT Emulsion Polymerization of Styrene Derivatives Containing Phosphorous

The reversible addition–fragmentation chain transfer (RAFT) emulsion polymerization of diethyl-(4-vinylbenzyl) phosphate (DEVBP) was performed using PEG-TTC as a macro RAFT agent. PEG-TTC (MW 2000, 4000) was synthesized by the esterification of poly (ethylene glycol) methyl ether with a carboxylic-terminated RAFT agent, composed a hydrophilic poly (ethylene glycol) (PEG) block and a hydrophobic dodecyl chain. The RAFT emulsion polymerization of DEVBP was well–controlled with a narrow molecular size distribution. Dynamic light scattering and confocal laser scanning microscopy were used to examine the PEG-b-PDVBP submicron particles, and the length of the PEG chain (hydrophilic block) was found to affect the particle size distribution and molecular weight distribution. The submicron particle size increased with increasing degree of polymerization (35, 65, and 130), and precipitation was observed at a high degree of polymerization (DP) using low molecular weight PEG-TTC (DP 130, A3). The flame retardant properties of the PEG-b-PDVBP were evaluated by thermogravimetric analysis (TGA) and micro cone calorimeter (MCC). In the combustion process, the residue of PEG-b-PDEVBP were above 500 °C was observed (A1 ~ B3, 27 ~ 38%), and flame retardant effect of PEG-b-PDEVBP submicron particles/PVA composite were confirmed by increasing range of temperature and decreasing total heat release with increasing contents of PEG-b-PDEVBP. The PEG-b-PDEVBP submicron particles can provide flame retardant properties to aqueous, dispersion and emulsion formed organic/polymer products.
Efficacy of Penicillium funiculosum as a biological control agent against phytophthora root rots of Azalea and citrus

Penicillium funiculosum was evaluated in the greenhouse for its ability to suppress Phytophthora root rots of azalea (Rhododendron spp.) and sweet orange (Citrus sinensis) as measured by increased shoot and root growth. The antagonist was grown in a wheat bran-peat moss (1:1) medium, which was then mixed into a peat-perlite (3:1) planting mix at a concentration of 0.7% (wt/vol). Rooted azalea cuttings or sweet orange seedlings were transplanted into the planting mix, which was inoculated with Phytophthora 5 to 7 days later. In most of the tests, P. funiculosum effectively increased the shoot growth and root weight of azalea in media infested with P parasitica and those of sweet orange in media infested with P. citrophthora. It also reduced, to some degree, root rots caused by P cinnamomi on azalea and by P parasitica on sweet orange. Three subisolates of P funiculosum (T327H, T327L, and T327S) exhibited different degrees of root rot suppression; T327S provided the best control. The population density of each of these subisolates increased in the planting mix during the first 4 weeks and decreased thereafter. Mixing the P funiculosum bran-peat inoculum into the planting mix was a more effective method for delivering the biocontrol agent than dipping the plant root systems into a P funiculosum spore suspension before transplantation. P funiculosum was also effective in increasing plant growth when the bran-peat inoculum was used at concentrations lower than 0.7%. P. funiculosum inoculum applied at a concentration of 0.35% twice during a 12-week period was more effective in the biocontrol of azalea root rot caused by P. cinnamomi than when it was applied only once. P. funiculosum also reduced sweet orange root rot caused by P. citrophthora in some other planting mixes.
[Mechanism of Aurantii Fructus Immaturus volatile oil in treatment of slow transit constipation based on network pharmacology].

To construct the active component-action target network diagram and protein-protein interaction(PPI) network diagram of Aurantii Fructus Immaturus volatile oil, so as to explore the mechanism of Aurantii Fructus Immaturus volatile oil in the treatment of slow transit constipation(STC) by analyzing the functions and pathways involved in the target. The chemical constituents of Aurantii Fructus Immaturus volatile oil were determined by gas chromatography-mass spectrometry(GC-MS). The targets of Aurantii Fructus Immaturus volatile oil were studied by PubChem, TCMSP, STITCH and Swiss Target Prediction. OMIM, Genecards-Search Resuits and TTD were used to screen out the targets of Slow Transit Constipation. The active component-action targets and PPI network diagram were constructed by Cytoscape 3.7. 1. The target organ distribution was analyzed by BioGPS database. GO and KEGG pathways involved in the targets were analyzed by R language. The molecular docking between the components and the targets was verified by Discovery Studio 2.5 software. Finally, 15 volatile oil compounds from Aurantii Fructus Immaturus were detected, and 115 targets of volatile oil in the treatment of STC were predicted. GO enrichment analysis showed that the activity of Aurantii Fructus Immaturus volatile oil mainly involved blood circulation, circulation system process, response to steroid hormone, signal release and other biological processes. There were 23 KEGG enrichment pathways, among which Neuroactive ligand-receptor interaction, cAMP signaling pathway, Endocrine resistance, Calcium signaling pathway and Serotonergic synapse pathways played a significant role in STC. The results of molecular docking showed that relevant target proteins for the treatment of STC were ACHE, PTGS2, SLC6 A2 and CNR2.The multi-component, multi-target and multi-pathwaycharacteristics of Aurantii Fructus Immaturus volatile oil were revealed by network pharmacology, which provided a new therapeutic idea and method for the further study of the mechanism of Aurantii Fructus Immaturus volatile oil in the treatment of STC.
Relative Efficiency of Multifilament and Monofilament Nylon Gill Net Towards Lake Whitefish (Coregonus clupeaformis) in Lake Huron

In the early 1970s Lake Huron fishermen converted their gill nets from multifilament to monofilament nylon web in the lake whitefish (Coregonus clupeaformis) fishery. Catch comparisons in the two gears showed that monofilament nets were 1.8 times more efficient (but varied seasonally), resulting in biased commercial catch statistics. The use of monofilament web has probably increased exploitation pressure on whitefish. Both gears selected whitefish of the same size despite stock differences in individual size and shape. Catches in both gears declined during the full moon phase, possibly due to increased net visibility. Key words: mono-multifilament gillnet efficiency, selectivity, lunar illuminance, Coregonus clupeaformis, Lake Huron
Resting-state fMRI analysis in apathetic Alzheimer's disease.

PURPOSE Diagnosis of comorbid psychiatric conditions are a significant determinant for the prognosis of neurodegenerative diseases. Apathy, which is a behavioral executive dysfunction, frequently accompanies Alzheimer's disease (AD) and leads to higher daily functional loss. We assume that frontal lobe hypofunction in apathetic AD patients are more apparent than the AD patients without apathy. This study aims to address the neuroanatomical correlates of apathy in the early stage of AD using task-free functional magnetic resonance imaging (MRI). METHODS Patients (n=20) were recruited from the Neurology and Psychiatry Departments of İstanbul University, İstanbul School of Medicine whose first referrals were 6- to 12-month history of progressive cognitive decline. Patients with clinical dementia rating 0.5 and 1 were included in the study. The patient group was divided into two subgroups as apathetic and non-apathetic AD according to their psychiatric examination and assessment scores. A healthy control group was also included (n=10). All subjects underwent structural and functional MRI. The resting-state condition was recorded eyes open for 5 minutes. RESULTS The difference between the three groups came up in the pregenual anterior cingulate cortex (pgACC) at the trend level (P = 0.056). Apathetic AD group showed the most constricted activation area at pgACC. CONCLUSION The region in and around anterior default mode network (pgACC) seems to mediate motivation to initiate behavior, and this function appears to weaken as the apathy becomes more severe in AD.
Biomimetic Nanomembranes: An Overview

Nanomembranes are the principal building block of basically all living organisms, and without them life as we know it would not be possible. Yet in spite of their ubiquity, for a long time their artificial counterparts have mostly been overlooked in mainstream microsystem and nanosystem technologies, being a niche topic at best, instead of holding their rightful position as one of the basic structures in such systems. Synthetic biomimetic nanomembranes are essential in a vast number of seemingly disparate fields, including separation science and technology, sensing technology, environmental protection, renewable energy, process industry, life sciences and biomedicine. In this study, we review the possibilities for the synthesis of inorganic, organic and hybrid nanomembranes mimicking and in some way surpassing living structures, consider their main properties of interest, give a short overview of possible pathways for their enhancement through multifunctionalization, and summarize some of their numerous applications reported to date, with a focus on recent findings. It is our aim to stress the role of functionalized synthetic biomimetic nanomembranes within the context of modern nanoscience and nanotechnologies. We hope to highlight the importance of the topic, as well as to stress its great applicability potentials in many facets of human life.
Geomaterials Evaluation: A New Application of Ashby Plots

The development of fossil energy resources and the occurrence of geological hazards call for a quick and effective identification of geological situations. In this study, we present rapid evaluations of geological structures from the pure point of view of material properties. For the first time, Ashby plots are applied to the evaluation of geomaterials such as rocks and coals. A series of case studies are presented and related Ashby plots are drawn. The stability of rocks facing natural hazards is analyzed and compared; the stability of coals formed in different periods in China is studied; and a new brittleness index for reservoir rocks is proposed. The Ashby plots show a strong vitality and a wide application prospect in geomaterial evaluation and geological engineering.
Animal Models Used in Hepatitis C Virus Research

The narrow range of species permissive to infection by hepatitis C virus (HCV) presents a unique challenge to the development of useful animal models for studying HCV, as well as host immune responses and development of chronic infection and disease. Following earlier studies in chimpanzees, several unique approaches have been pursued to develop useful animal models for research while avoiding the important ethical concerns and costs inherent in research with chimpanzees. Genetically related hepatotropic viruses that infect animals are being used as surrogates for HCV in research studies; chimeras of these surrogate viruses harboring specific regions of the HCV genome are being developed to improve their utility for vaccine testing. Concurrently, genetically humanized mice are being developed and continually advanced using human factors known to be involved in virus entry and replication. Further, xenotransplantation of human hepatocytes into mice allows for the direct study of HCV infection in human liver tissue in a small animal model. The current advances in each of these approaches are discussed in the present review.
Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer’s Disease Therapy

In this communication, we report the synthesis and cholinesterase (ChE)/monoamine oxidase (MAO) inhibition of 19 quinolinones (QN1-19) and 13 dihydroquinolinones (DQN1-13) designed as potential multitarget small molecules (MSM) for Alzheimer’s disease therapy. Contrary to our expectations, none of them showed significant human recombinant MAO inhibition, but compounds QN8, QN9, and DQN7 displayed promising human recombinant acetylcholinesterase (hrAChE) and butyrylcholinesterase (hrBuChE) inhibition. In particular, molecule QN8 was found to be a potent and quite selective non-competitive inhibitor of hrAChE (IC50 = 0.29 µM), with Ki value in nanomolar range (79 nM). Pertinent docking analysis confirmed this result, suggesting that this ligand is an interesting hit for further investigation.