Miracle-dz/UniFAR-FTUs huggingface dataset:
Radar analysis algorithm for determining meteor head echo parameter probability distributions

We present an automated radar data analysis algorithm developed to calculate probability distributions of meteor- and meteoroid parameters for head echoes detected with the Middle and Upper atmosphere (MU) radar in Shigaraki, Japan. The algorithm utilizes direct Monte Carlo simulations of uncertainties, with Bayesian Markov-chain Monte Carlo estimation of meteor model parameters and N-body propagation of distributions to perform orbit determination. The implementation has been validated using raw data simulations and a comparison with previous analysis methods. The concepts are applicable on a wide range of possible head echo measurements with other radar systems. The generated probability distributions provide quantitative reliability, which enables improved statistical studies and investigating the origins of detected meteoroids. The methodology section is highly detailed in order for the methods to be reproducible and provide a solid reference foundation for future studies. One such study is presented in a companion paper called ‘High-altitude meteors detected by the interferometric MU radar’.
REANALYSIS OF THE GRAVITATIONAL MICROLENSING EVENT MACHO-97-BLG-41 BASED ON COMBINED DATA

MACHO-97-BLG-41 is a gravitational microlensing event produced by a lens composed of multiple masses detected by the first-generation lensing experiment. For the event, there exist two different interpretations of the lens from independent analyses based on two different data sets: one interpreted the event as produced by a circumbinary planetary system while the other explained the light curve with only a binary system by introducing orbital motion of the lens. According to the former interpretation, the lens would not only be the first planet detected via microlensing but also the first circumbinary planet ever detected. To resolve the issue using state-of-the-art analysis methods, we reanalyze the event based on the combined data used separately by the previous analyses. By considering various higher-order effects, we find that the orbiting binary-lens model provides a better fit than the circumbinary planet model with Δχ2 ∼ 166. The result signifies the importance of even and dense coverage of lensing light curves in the interpretation of events.
A Functionalized Membrane Layer as Part of a Dressing to Aid Wound Healing

Purpose: This study is an approach to a dressing platform based on support functionalized with oxygenating factors within an alginate layer, constituting a safe and even contact surface for interface with a wound. Methods: An alginate layer with incorporated oxygenating elements deposited on the support patch was assessed. As an oxygenating factor, perfluorooctyl was applied, and the layer coatings in two options, cross-linked and not, were evaluated. The function of human dermal fibroblast cells cultured in the presence of these constructs was analyzed, as well as their morphology using flow cytometry, fluorescence microscopy, and scanning electron microscopy. In addition, the membrane coating material was assessed using FTIR, AFM, and SEM-EDX characterization. Results: The applied membrane coatings adsorbed on the patch ensured the viability of the human fibroblasts cultured on the membranes during 10 days of culture. However, on the sixth day of culture, the percentage of live cells grown in the presence of cross-linked alginate with oxygenating factor ((ALG-PFC)net) was significantly higher than that of the cells cultured in the presence of the alginate coatings alone. SEM-EDX analysis of the (ALG-PFC)net confirmed the presence of oxygenating and cross-linking factors. In addition, the regular granular branched structure of the layer coating material involving the oxygenating and cross-linking factors was observed using the AFM technique. Conclusion: The topography of the layer coating material involving the oxygenating and cross-linking factors ensures an even contact surface for interface with the wound. Considering 5-day intervals between dressing replacements, the platform with an oxygenating configuration ensuring the growth and morphology of the human fibroblasts can be recommended at this time as an element of a dressing system.
The Association between Perpetuation of Intimate Partner Violence and Family Support on Couples with an Incarcerated Partner

The ripple effect of incarceration is multifaceted. Studies show that imprisonment impacts the well-being of intimate and extended familial relationships, parental involvement, and financial support. Using data from the Multi-site Family Study on Incarceration, Parenting, and Partnering [MFS-IP], this study examined the effects of incarceration on families. The focus of this study is to examine the effect of family support on perpetrating physical violence. The findings revealed that the actor effect for men (p < 0.05) is statistically significant, meaning that men with less family support perpetuate higher levels of intimate partner violence (IPV). The partner effects for men to women (p < 0.05) is also statistically significant, meaning women with less family support coincide with men’s higher levels of IPV perpetration. Further, the effect of romantic attachment on perpetrating physical violence for men (p = 0.034) is statistically significant, meaning higher levels of romantic attachment towards the female partner coincides with their lower levels of perpetration of IPV. Clinical implications and future directions are provided.
Sequential Isolation of Microglia and Astrocytes from Young and Aged Adult Mouse Brains for Downstream Transcriptomic Analysis

In aging, the brain is more vulnerable to injury and neurodegenerative disease, but the mechanisms responsible are largely unknown. Evidence now suggests that neuroinflammation, mediated by resident brain astrocyte and microglia populations, are key players in the generation of inflammatory responses and may influence both age related processes and the initiation/progression of neurodegeneration. Consequently, targeting these cell types individually and collectively may aid in the development of novel disease-modifying therapies. We have optimized and characterized a protocol for the effective sequential isolation of both microglia and astrocytes from the adult mouse brain in young and aged mice. We demonstrate a technique for the sequential isolation of these immune cells by using magnetic beads technology, optimized to increase yield and limit potential artifacts in downstream transcriptomic applications, including RNA-sequencing pipelines. This technique is versatile, cost-effective, and reliable for the study of responses within the same biological context, simultaneously being advantageous in reducing mice numbers required to assess cellular responses in normal and age-related pathological conditions.
The Scale-invariant Power Spectrum of Primordial Curvature Perturbation in CSTB Cosmos

We investigate the spectrum of cosmological perturbations in a bounce cosmos modeled by a scalar field coupled to the string tachyon field (CSTB cosmos). By explicit computation of its primordial spectral index we show the power spectrum of curvature perturbations, generated during the tachyon matter dominated contraction phase, to be nearly scale invariant. We propose a unified space of parameters for a systematic study of inflationary/bouncing cosmologies. We find that CSTB cosmos is dual–in Wands’s sense–to the slow-roll inflation model as can be easily seen from this unified parameter space. Guaranteed by the dynamical attractor behavior of CSTB Cosmos, this scale invariance is free of the fine-tuning problem, in contrast to the slow-roll inflation model.
Osmotic Ion Concentration Control of Steady-State Subcritical Fracture Growth in Shale

The mechanism of formation of natural cracks in sedimentary rocks in the geologic past is an important problem in hydraulic fracturing. Why are the natural cracks roughly parallel and equidistant, and why is the spacing in the order of 10 cm rather than 1 cm or 100 cm? Fracture mechanics alone cannot answer these questions. Here it is proposed that fracture mechanics must be coupled with the diffusion of solute ions (Na+ and Cl- are considered here), driven by an osmotic pressure gradient. Parallel equidistant cracks are considered to be subcritical and governed by the Charles-Evans law. The evolution in solute concentration also affects the solvent pressure in the pores and cracks, altering the resistance to frictional sliding. Only steady-state propagation and periodic cracks are studied. An analytical solution of the crack spacing as a function of the properties of the rock as well as the solvent and solute, and the imposed far-field deformation is obtained. Finally, the stability of the growth of parallel cracks is proven by examining the second variation of free energy. Stability of the periodic growth state is also considered.
Far-UV to mid-IR properties of nearby radio galaxies

We investigate whether the far-UV continuum of nearby radio galaxies reveals evidence for the presence of star forming or non-stellar components. If a UV excess due to an extra radiation component exists we compare this with other properties such as radio power, optical spectral type and the strength of the emission lines. We also discuss the possible correlation between the ultra-violet flux, IR properties and central black hole mass. We use two sampes of low luminosity radio galaxies with comparable redshifts ($z < 0.2$). Spectral Energy Distributions are constructed using a number of on-line databases: GALEX, SDSS, 2MASS, and WISE. The parameter $XUV$ is introduced, which measures the excess slope of the UV continuum between 4500 and 2000 \AA, with respect to the UV radiation produced by the underlying old galaxy component. We find that the UV excess is usually small or absent in low luminosity sources, but sets in abruptly at the transition radio power above which we find mostly FRII sources. $XUV$ behaves very similarly to the strength of the optical emission lines (in particular $H\alpha$). Below $P_{1.4 GHz} < 10^{24}$ WHz$^{-1}$ $XUV$ is close to zero. $XUV$ correlates strongly with the $H\alpha$ line strength, but only in sources with strong $H\alpha$ emission. There is a strong correlation between $XUV$ and the slope of the mid-IR, as measured by the WISE bands in the interval 3.4 to 22 $\mu$m, in the sense that sources with a strong UV excess also have stronger IR emission. There is an inverse correlation between $XUV$ and central black hole mass: strong UV excess objects have, on average, $M_{BH}$ about 2-3 times less massive than those without UV excess. Low luminosity radio galaxies tend to be more massive and contain more massive black holes.
XyloFUNS: Xylocaine to freeze during unpleasant nasopharyngeal swabs in children—a randomized controlled trial

Abstract Objectives To evaluate the efficacy of intranasal vaporized lidocaine in reducing pain for children undergoing a nasopharyngeal (NP) swab in the Emergency Department (ED). Study Design A randomized blinded clinical trial was conducted in a paediatric ED. Both participants and the researcher evaluating the primary outcome were blinded. Children aged 6 to 17 years old requiring a NP swab were eligible. Participants were randomly allocated to receive intranasal lidocaine or a sham treatment prior to their NP swab. The primary outcome measure was pain during the swab as assessed by the visual analog scale. Secondary outcome measures were pain using the verbal numeric rating scale, fear using the children fear scale, and adverse effects of the intervention. Results Eighty-eight participants were enrolled—45 in the lidocaine group and 43 controls. The mean visual analog scale scores for pain were 46 mm in the lidocaine group and 53 mm in the control group (mean difference 7 mm; 95% CI: −5 to 19 mm). No serious adverse events were observed. Conclusions Intranasal lidocaine administered prior to NP swabs in the ED failed to show an improvement in pain scores for school-aged children and youth.
A dream job? Skill demand and skill mismatch in ICT

ABSTRACT We analyse labour demand and mismatch for educational traits in information and communication technology (ICT) occupations, taking into account the areas of education, occupations and skills in demand, and the supply of labour. We based our analysis on almost 40 million online job offers and a CAWI survey of people aged 18–65 in Poland. The analysis uses official classifications, and considers both job-related and transversal skills. To analyse an objective measure of mismatch, we compare job requirements stated in job offers to the declared characteristics of potential labour supply, and present demand and mismatch for skills across occupations. We also model a declared educational mismatch and its determinants, including educational profiles of surveyed participants. In order to further investigate the mismatches in ICT fields of education, occupations and skills, we compare them with the mismatches in other occupational groups. The analysis concludes with direct educational policy recommendations, including the Sectoral Qualifications Framework for ICT occupations in Poland. Our approach shows the complete educational characteristics of skill demands and skill mismatches.
Preparation and Evaluation of Microwave Generated Nanocomposites for Solubility Enhancement of Ketoprofen

Ketoprofen is non-steroidal anti-inflammatory drug (NSAID) used for treatment of rheumatoid arthritis. Ketoprofen belongs to BCS class II having low solubility which imposes challenge in development of oral dosage form. Nanocomposite formation is novel technique used for solubility enhancement. Microwaves were utilised for formation of nanocomposites. Polymers like HPMC, tragacanth, acacia, avicel were used as carrier for formulation of nanocomposites. From physical characterization of polymers like foaming index, viscosity and swelling index, HPMC and tragacanth were used for further study. 8 different formulations were prepared with varying ratio of drug and carrier and corresponding physical mixtures were also prepared. KTHN (1:4), KTTN (1:4) were the best ratios from different nanocomposites formulations, which showed high solubility. In-vitro drug release showed the drug dissolution of 85.72% in comparison to pure Ketoprofen which showed dissolution of 48.31%. Prepared nanocomposites were investigated for various parameters like FTIR, DSC, SEM. Stability study for 3 months indicated no significant change in appearance, drug content and in-vitro drug release of the nanocomposites. The overall results indicated that microwave assisted formulation of nanocomposites can be used to increase solubility of ketoprofen.
The integrated Sachs-Wolfe imprint of cosmic superstructures: a problem for ΛCDM

A crucial diagnostic of the ΛCDM cosmological model is the integrated Sachs-Wolfe (ISW) effect of large-scale structure on the cosmic microwave background (CMB). The ISW imprint of superstructures of size ~ 100 h−1Mpc at redshift z ~ 0.5 has been detected with > 4σ significance, however it has been noted that the signal is much larger than expected. We revisit the calculation using linear theory predictions in ΛCDM cosmology for the number density of superstructures and their radial density profile, and take possible selection effects into account. While our expected signal is larger than previous estimates, it is still inconsistent by > 3σ with the observation. If the observed signal is indeed due to the ISW effect then huge, extremely underdense voids are far more common in the observed universe than predicted by ΛCDM.
Study of nonequilibrium Kondo phenomenon via nonperturbative dynamical theory

We develop a nonperturbative dynamical theory (NDT) to calculate the retarded Green's function under nonequilibrium conditions. The NDT is particularly useful for treating nonequilibrium transport problems in systems with strong correlation. We apply our NDT to the well-known single-impurity Anderson model at equilibrium to determine its feasibility. We then apply it to a nonequilibrium transport problem in a system with Kondo coupling. An Anderson model with two metallic reservoirs is studied to understand the phenomenon of Kondo-peak splitting in a single-electron transistor of mesoscopic size. We calculate the nonequilibrium retarded Green's function by using the NDT and analyze it in the atomic limit, where the novel coherent phenomenon manifested only under nonequilibrium conditions can be described in an analytical manner. We finally construct a self-consistent loop to calculate the retarded Green's function and present the results for spectral density and differential conductance obtained by the self-consistent method. Our results explain all the features of Kondo-peak splitting observed in experiments. One remarkable conclusion is that Kondo-peak splitting is not the splitting of a conventional Kondo peak, but the splitting of a novel coherent peak created under nonequilibrium steady-state conditions.
The galaxy luminosity function and the Local Hole.

In a previous study Whitbourn & Shanks have reported evidence for a local void underdense by ≈15 per cent extending to 150–300 h−1 Mpc around our position in the Southern Galactic Cap (SGC). Assuming a local luminosity function they modelled K- and r-limited number counts and redshift distributions in the 6dFGS/2MASS and SDSS redshift surveys and derived normalized n(z) ratios relative to the standard homogeneous cosmological model. Here we test further these results using maximum likelihood techniques that solve for the galaxy density distributions and the galaxy luminosity function simultaneously. We confirm the results from the previous analysis in terms of the number density distributions, indicating that our detection of the ‘Local Hole’ in the SGC is robust to the assumption of either our previous, or newly estimated, luminosity functions. However, there are discrepancies with previously published K- and r-band luminosity functions. In particular the r-band luminosity function has a steeper faint end slope than the r0.1 results of Blanton et al. but is consistent with the r0.1 results of Montero-Dorta & Prada and Loveday et al.
Strandings in St Vincent Gulf Bioregion, South Australia: 12-Year Study Monitors Biology and Pathology of Cetaceans

The semi-enclosed environment of the St Vincent Gulf Bioregion and its fauna are impacted by many human activities. Long-term monitoring of cetaceans is vital. Records of collected specimens (173) and those not examined by the South Australian Museum (98 non-specimens) from 2009–2020 were analyzed. Necropsies were carried out on most carcasses using gross, histopathological, and diagnostic assessment of pathogens, organs, and skin lesions. The relative age and circumstance of death were assigned. Baleen whales (five species) and odontocetes (eight species) were studied. Indo-Pacific bottlenose dolphins (Tursiops aduncus) and common dolphins (Delphinus delphis) were frequently recorded and analyzed in detail. Anthropogenic cases were prevalent (21%). Many dolphins (62%) were immature males. Disease (73%) was the most frequently recorded circumstance of death. The most common pathological change was inflammatory disease, including infectious pneumonia. In Indo-Pacific bottlenose dolphins, infectious disease was more prevalent in the greater St Vincent Gulf Bioregion than in the Adelaide Dolphin Sanctuary. Microbe testing confirmed 32 species of bacteria, 2 fungi, and 1 virus. Nematodes and trematodes were recorded throughout the study, sometimes in association with microbes. Toxoplasma gondii was observed in an Indo-Pacific bottlenose dolphin. Severe traumatic injury was recorded in many dolphins, including anthropogenic cases. A tumor (leiomyoma) was described from a single common dolphin. This study provides an important baseline for the future monitoring of emerging infectious and chronic diseases, and anthropogenic threats in the region.
Cross-Domain Text Mining to Predict Adverse Events from Tyrosine Kinase Inhibitors for Chronic Myeloid Leukemia

Simple Summary Tyrosine kinase inhibitor (TKI) therapy is often taken indefinitely by chronic myeloid leukemia (CML) patients. However, little is known about the long-term or under-reported TKI side effects due to limited longitudinal clinical data on these relatively new drugs. We utilize novel cross-domain text mining and machine learning to comprehensively assess relationships between TKIs and possible adverse events (AEs) across 30+ million PubMed publications. The top 10% of predicted AEs were mapped to ten physiological function-based foci: hematology, glucose, iron, cardiovascular, thyroid, inflammation, kidney, gastrointestinal, neuromuscular, and others. Study results provided new insight into the breadth of adverse events with TKI usage. Results-based recommendations were devised for proactive patient monitoring protocols as a function of perceived AE risk. Additionally, AEs were mapped to specific TKI types to assist in personalized TKI selection. Abstract Tyrosine kinase inhibitors (TKIs) are prescribed for chronic myeloid leukemia (CML) and some other cancers. The objective was to predict and rank TKI-related adverse events (AEs), including under-reported or preclinical AEs, using novel text mining. First, k-means clustering of 2575 clinical CML TKI abstracts separated TKIs by significant (p < 0.05) AE type: gastrointestinal (bosutinib); edema (imatinib); pulmonary (dasatinib); diabetes (nilotinib); cardiovascular (ponatinib). Next, we propose a novel cross-domain text mining method utilizing a knowledge graph, link prediction, and hub node network analysis to predict new relationships. Cross-domain text mining of 30+ million articles via SemNet predicted and ranked known and novel TKI AEs. Three physiology-based tiers were formed using unsupervised rank aggregation feature importance. Tier 1 ranked in the top 1%: hematology (anemia, neutropenia, thrombocytopenia, hypocellular marrow); glucose (diabetes, insulin resistance, metabolic syndrome); iron (deficiency, overload, metabolism), cardiovascular (hypertension, heart failure, vascular dilation); thyroid (hypothyroidism, hyperthyroidism, parathyroid). Tier 2 ranked in the top 5%: inflammation (chronic inflammatory disorder, autoimmune, periodontitis); kidney (glomerulonephritis, glomerulopathy, toxic nephropathy). Tier 3 ranked in the top 10%: gastrointestinal (bowel regulation, hepatitis, pancreatitis); neuromuscular (autonomia, neuropathy, muscle pain); others (secondary cancers, vitamin deficiency, edema). Results suggest proactive TKI patient AE surveillance levels: regular surveillance for tier 1, infrequent surveillance for tier 2, and symptom-based surveillance for tier 3.