Miracle-dz/UniFAR-FTUs huggingface dataset:
OP-NDTJ210268 1..11

Background. Age-related reduction of glomerular filtration rate (GFR) is a major contributor to the global chronic kidney disease (CKD) epidemic. We investigated whether baseline serum levels of the pro-fibrotic matrix metalloproteinase 2 (MMP2), MMP7 and their inhibitor, tissue inhibitor of metalloproteinase 1 (TIMP1), which mediates fibrosis development in aging animals, were associated with GFR decline in a general non-diabetic population. Methods. In the Renal Iohexol Clearance Survey, we measured GFR using iohexol clearance in 1627 subjects aged 50–64 years without self-reported diabetes, kidney or cardiovascular disease. G R A P H I C A L A B S T R A C T LEADING EUROPEAN NEPHROLOGY VC The Author(s) 2021. Published by Oxford University Press on behalf of ERA. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/ by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial reuse, please contact journals.permissions@oup.com 1 O R IG IN A L A R T IC LE Nephrol Dial Transplant (2021) 1–11 doi: 10.1093/ndt/gfab251 Advance Access publication 26 August 2021 LEADING EUROPEAN NEPHROLOGY NEPHROLOGY DIALYSIS TRANSPLANTATION D ow naded rom http/academ ic.p.com /ndt/advance-arti.1093/ndt/gfab251/6358147 by gest on 18 O cber 2021 After a median of 5.6 years, 1324 had follow-up GFR measurements. Using linear mixed models and logistic regression analyses, we evaluated the association of MMP7, MMP2 and TIMP1 with the mean GFR decline rate, risk of accelerated GFR decline (defined as subjects with the 10% steepest GFR slopes: 1.8 mL/min/1.73 m/year) and incident CKD [GFR<60 mL/ min/1.73 m and/or urinary albumin to creatinine ratio (ACR) 3.0 mg/mmol]. Results. Higher MMP7 levels (per standard deviation increase of MMP7) were associated with steeper GFR decline rates [ 0.23 mL/min/1.73 m/year (95% confidence interval 0.34 to 0.12)] and increased risk of accelerated GFR decline and incident CKD [odds ratios 1.58 (1.30–1.93) and 1.45 (1.05–2.01), respectively, in a model adjusted for age, sex, baseline GFR, ACR and cardiovascular risk factors]. MMP2 and TIMP1 showed no association with GFR decline or incident CKD. Conclusions. The pro-fibrotic biomarker MMP7, but not MMP2 or TIMP1, is associated with increased risk of accelerated GFR decline and incident CKD in middle-aged persons from the general population.
Sexual Behaviour or Married Men during Pregnancy and After Childbirth in Ibu Ian: Evidence from Focus Group Discussions.

' Male role and responsibility in reproductive health matters JUIl'1:' become consistent prerequisites to understanding maternal issues generally. , Through Jocus group discussions (FGDs};this. exploratory research investigates sexualbehaviour oj married men during pregnancy.tind afterbirth in .Ibadan Southwestern Nigeria as a way oj highlightingthe-/inks between these. periods and pregnancy Oil/comes and the health stat us of couples. The study '. shows lliut sexual behuviourof men is influencedby 'he intcrpluy . of reIigio LIS, , socio-cultural and ideological factors. The specific results coitus with their pregnant LIpper limit oj 4 - months among the Hausa;: postpartum sexual abstinence varies in duration with an average of -10 days across cultural settings; one sixth oj the respondents agreed engaging in sexual intercourse With other womell in order Io- reducetheir wives' vulnerability to the risks associated with pregnancy; and while men often use condom to prevent sexually transniiued injections (STIs) from women other than their wives, most married men with established or presumed cases of S'Tl: appear /0 be relatively casual and undiplomatic in handling this issue. These findings suggest that programmes large/edat husbands and their reproductive' health orientation appear necessary to reduce the frequency negative reproductive health outcomes among couples.
Revisiting Adjuvant Hormone Therapy in Premenopausal Women With Breast Cancer: Escalation and De-Escalation.

have published guidelines for locoregional breast cancer that suggest in premenopausal women, clinicians should give adjuvant tamoxifen for 5 years in low-risk breast cancer, extend hormone therapy in high-risk patients, and consider adding ovarian function suppression (OFS) in patients with a higher risk of relapse. However, the guidelines are relatively am-biguous about patient selection. 1,2 The article by Sella et al 3 is of great value in guiding clinical decision making. However, some points remain to be elucidated.
Influence of spo Mutations on aE Synthesis in Bacillus subtilis

Bacillus subtilis mutants blocked at the same stage of development (stage II) as strains with mutations in the structural gene for CE (sigE[spoIIGB]) were analyzed immunologically for SE and its precursor protein, p3l. Mutations at spollL, spolIN, and spoIIJ loci but not at the spolIM locus significantly reduced P3' formation. Mutations at the spolIAA, spolIAC, spoIIEA, spollEB, and spolIEC loci did not affect p31 synthesis but blocked its processing into SE. These results demonstrate a requirement for at least eight stage II gene products in the developmental pathway which leads to SE and brings to 11 the number of stage II genes (including spolIGA, spoJIGB, and spolIF) now known to be needed for SE formation.
University of Birmingham Occipital nerve stimulation for chronic migraine - a systematic review and meta-analysis

Background Chronic migraine is a debilitating headache disorder that has significant impact on quality of life. Stimulation of peripheral nerves is increasingly being used to treat chronic refractory pain including headache disorders. This systematic review examines the effectiveness and adverse effects of occipital nerve stimulation (ONS) for chronic migraine. Methods assessed using carried using Findings and plots. Five RCTs (total n=402) and seven case (total n=115) Pooled results from three multicenter RCTs show that ONS was associated with a mean reduction of 2.59 days (95% CI 0.91 to 4.27, I2=0%) of prolonged, moderate to severe headache per month at 3 months compared with a sham control. Results for other outcomes generally favour ONS over sham controls but quantitative analysis was hampered by incomplete publication and reporting of trial data. Lead migration and infections are common and often require revision surgery. Open-label follow-up of RCTs and case series suggest long-term effectiveness can be maintained in some patients but evidence is limited.
User perspective on AM-enabled mass customisation toolkits

Mass Customisation (MC) toolkits are powerful user interfaces that enable customers to engage in the design of their own products. This research follows design research methodology (integrated with design process) to research the user perspective on AM-enabled MC toolkits. This research proposes and validates a design framework to guide designers and software developers in designing a user-centred AM-enabled MC toolkits, enabled using digital fabrication technologies such as Additive Manufacturing (AM). This framework includes pre-implementation assessment, and implementation stages. An initial literature review revealed a lack of standard or universal norms for these user interfaces, and a lack of consistency in their design, in which web objects such as logo, product image, prices, etc. are not shared commonly among toolkits, nor occupy a frequent position. Furthermore, an optimum number of degree of freedom for MC toolkits is lacking from current design knowledge. This research focuses on AM-enabled Mass Customisation toolkits as a means to enable customers design; its concentration is on users. A first quantitative study was conducted to compare and rank of a collection of features. More detailed user requirements regarding the content and layout of MC toolkits were revealed in a workshop. As a part of the second study, four different CAD systems (software programs and 3D-enabling libraries) were used to create MC toolkits. This provided an understanding of the pros and cons of each system, and demonstrated Three.js to be the best system amongst each one s feasibility and application. Based on previous findings, and as a part of the UX-design process, a prototype web-based MC toolkit was constructed, utilising the Three.js library. The prototype was used for a second study as a platform to investigate, the user interaction and usability of the toolkit, to validate the toolkit design as well as provide insights for its improvement. Findings and reflections from all the studies were then visualised and communicated in an interactive design framework. A final study, conducted with professional users (N=4) assessed the usability and technicality of the framework tool and led to a number of suggested improvements. The main contributions to knowledge are: 1- a table was produced to compare the features of four different system, by which Three.js was identified as the most suitable among them 2- most important and expected features for the content were obtained from the user rankings, most frequent location of features for the layout was identified based on the users, and user insights were reflected based on the evaluation of the prototype 3- the UI needs to be flexible in term of degrees of freedom, in another words, each customer (novice or professional) is able to adjust the number of options presented. 4- a framework was proposed through reviewing and adapting existing guidelines and findings from this research.
Vitamin D deficiency among older women with and without disability 1–3

Background: Vitamin D deficiency is associated with bone loss and bone fractures, and the identification of vulnerable populations is important to clinical practice and public health. Objective: The objectives of this study were to determine the prevalence of vitamin D deficiency and to examine associated risk factors for vitamin D deficiency in older women. Design: We measured serum concentrations of 25-hydroxyvita-min D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH) 2 D], intact parathyroid hormone (PTH), osteocalcin, and ionized calcium in women aged ≥ 65 y who were participating in the Women’s Health and Aging Study I, an observational study of women representing the approximately one-third most disabled women living in the community, and women aged 70–80 y who were participating in the Women’s Health and Aging Study II, an observational study of women among the two-thirds least disabled women living in the community in Baltimore. Results: The women were classified into 4 domains of physical disability. Among 371 women with 0 or 1 domain of disability and 682 women with ≥ 2 domains of disability, 6.2% and 12.6%, respectively, had vitamin D deficiency [serum concentrations of 25(OH)D < 25 nmol/L]. In univariate analyses, risk factors for vitamin D deficiency included increasing age, black race, low educational level, high body mass index, high triceps skinfold thickness, increasing level of disability, winter season, and elevated creatinine concentration. In multivariate models, black race had a strong association with vitamin D deficiency when other risk factors were adjusted for. Conclusions: Vitamin D deficiency, a preventable disorder, is a common and important public health problem for older disabled women living in the community; black women are at higher risk than are white women. J
Nitrate-regulated glutaredoxins control Arabidopsis thaliana primary root growth

SUMMARY: Nitrate activates a set of glutaredoxin proteins that act to slow the growth of the primary 34 root. 35 36 37 38 39 ABSTRACT 48 Nitrogen is an essential soil nutrient for plants, and lack of nitrogen commonly limits plant 49 growth. Soil nitrogen is typically available to plants in two inorganic forms: nitrate and ammonium. To 50 better understand how nitrate and ammonium differentially affect plant metabolism and development, we 51 performed transcriptional profiling of the shoots of ammonium-supplied and nitrate-supplied Arabidopsis 52 thaliana plants. Seven genes encoding class III glutaredoxins were found to be strongly and specifically 53 induced by nitrate. RNA silencing of four of these glutaredoxin genes ( AtGRXS3/4/5/8 ) resulted in plants 54 with increased primary root length (~25% longer than wild-type) and decreased sensitivity to nitrate- 55 mediated inhibition of primary root growth. Increased primary root growth is also a well-characterized 56 phenotype of many cytokinin-deficient plant lines. We determined that nitrate induction of glutaredoxin 57 gene expression was dependent upon cytokinin signaling and that cytokinins could activate glutaredoxin 58 gene expression independent of plant nitrate status. In addition, crosses between “long-root” cytokinin- 59 deficient plants and “long-root” glutaredoxin-silenced plants generated hybrids that displayed no further 60 increase in primary root length (i.e. epistasis). Collectively, these findings suggest that AtGRXS3/4/5/8 61 operate downstream of cytokinins in a signal transduction pathway that negatively regulates plant primary 62 root growth in response to nitrate. This pathway could allow Arabidopsis to actively discriminate between 63 different nitrogen sources in the soil, with the preferred nitrogen source, nitrate, acting to suppress 64 primary root growth (vertical dimension) in concert with its well-characterized stimulatory effect on 65 lateral root growth (horizontal dimension). 66 67 68 69 70 71
Neural Network Based Multimodal Emotion Estimation A study on Modalities used in Autonomous Systems

—This paper presents recent research on approaches in autonomous systems for combining multiple modalities for emotion estimation based on neural networks. Emotion recognition is an active area of research especially in the field of autonomous systems in automotive industry, Human Computer Interaction (HCI), multimedia indexing and video surveillance. Both invasive and non-invasive acquisition methods are part of this study. ECG and EEG, Voice and Facial Analysis with modern approaches such as Deep Neural Networks are presented.
Immune pro les of male giant panda (Ailuropoda melanoleuca) during breeding season

haibo shen Sichuan University https://orcid.org/0000-0002-2415-0463 Caiwu Li China Conservation and Research Center for the Giant Panda Ming He China Conservation and Research Center for the Giant Panda Yan Huang China Conservation and Research Center for the Giant Panda Jing Wang China Conservation and Research Center for the Giant Panda Minglei Wang China Conservation and Research Center for the Giant Panda Bisong Yue Sichuan University Xiuyue Zhang (  zhangxy317@126.com )
Synthase Exacerbates Erosive Joint Disease Selective Inhibition of Inducible Nitric Oxide

NO is an essential cytotoxic agent in host defense, yet can be autotoxic if overproduced, as evidenced in inﬂammatory lesions and tissue destruction in experimental arthritis models. Treatment of streptococcal cell wal1-induced arthritis in rats with N G -mono-methyl- L -arginine ( L -NMMA), a competitive nonspeciﬁc inhibitor of both constitutive and inducible isoforms of NO synthase (NOS), prevents intraarticular accumulation of leukocytes, joint swelling, and bone erosion. Because increased inducible NOS (iNOS) expression and NO generation are associated with pathogenesis of chronic inﬂammation, we investigated whether a selective inhibitor of iNOS, N -iminoethyl- L -lysine ( L -NIL), would have more directed anti-arthritic properties. Whereas both L -NMMA and L -NIL inhibited nitrite production by streptococcal cell wall-stimulated rat mononuclear cells in vitro and systemic treatment of arthritic rats with L -NMMA ablated synovitis, surprisingly L -NIL did not mediate resolution of inﬂammatory joint lesions. On the contrary, daily administration of L -NIL failed to reduce the acute response and exacerbated the chronic inﬂammatory response, as reﬂected by profound tissue destruction and loss of bone and cartilage. Although the number of iNOS-positive cells within the synovium decreased after treatment with L -NIL, immunohistochemical analyses revealed a distinct pattern of endothelial and neuronal NOS expression in the arthritic synovium that was unaffected by the isoform-speciﬁc L -NIL treatment. These studies uncover a contribution of the constitutive isoforms of NOS to the evolution of acute and chronic inﬂammation pathology which may be important in the design of therapeutic agents. The Journal of Immunology, 2001, 166: 2734–2740.
DEVELOPMENT OF A DYNAMIC MODEL FOR A 250 kW SUPERCRITICAL CO 2 SIMPLE REGENERATIVE BRAYTON CYCLE PLANT

Carleton University is designing and building a 250 kW supercritical CO 2 simple regenerative closed loop Brayton cycle power plant as a stand-alone facility, initially for ongoing research and development to understand plant performance under a variety of operating conditions. The project involves gas turbine design, heat exchanger design, piping system design, components and materials selection, control systems design, and dynamic modelling and simulation. Carleton University, in collaboration with Gastops Ltd., have developed a dynamic model of the pilot-scale power plant in the MATLAB-Simulink environment. The purpose of the dynamic model is to simulate steady state design and off-design operating points, transient state performance between operating points, potential equipment failure modes and their effects, control system strategies and algorithms, sensitivity analyses of key parameters on plant performance, and plant operation in support of demonstration, training, and troubleshooting. This paper presents an overview of the development of the dynamic model. Major components that have been modelled include the permanent magnet motor-generator, turbine, compressor, pipe impedance heater, recuperator, precooler, hot and cold piping system, bypass valve, throttle valve, inventory control system, and plant supervisory monitoring and control system. Both steady state and transient state simulation results have been generated to
Patient-Derived Antibody Data Yields Development of Broadly Cross-Protective Monoclonal Antibody against ST258 Carbapenem-Resistant Klebsiella pneumoniae

Here, we present in vitro and in vivo data for the wzi50 CPS-specific monoclonal antibody MAb 24D11, demonstrating its cross-protective efficacy against three prominent win types (wzi29, wzi154, and wzi50) of the carbapenem-resistant clonal group CG258. In a murine pulmonary infection model, MAb 24D11 reduced bacterial lung burden and dissemination to other organs even if administered 4 h postinfection. ABSTRACT The most pressing challenge for the development of anti-capsular antibodies is maximizing coverage against the heterogenous capsular polysaccharide (CPS) of carbapenem-resistant Klebsiella pneumoniae (CR-Kp). So far, only CR-Kp with wzi154 CPS has been successfully targeted by antibodies. Here, we present murine antibody 24D11, which was developed by vaccinating mice with purified wzi50-type CPS. Cross-reactivity and protective efficacy of MAb 24D11 were confirmed against CR-Kp that express the 3 most prevalent CPS types (wzi29, wzi154, wzi50) using both in vitro and in vivo infection models. 24D11 induced complement-mediated and independent opsonophagocytosis in macrophages as well as killing of all CR-Kp strains in whole blood cells derived from healthy donors. In a murine intratracheal infection model, 24D11 reduced lung burden and dissemination of CR-Kp strains when administered 4 h pre- or postinfection. The protective efficacy of 24D11 remained effective in neutropenic mice. This is the first antibody which exhibits cross-protective efficacy against clade 1 and 2 ST258 CR-Kp strains. It overcomes a major barrier to successfully target wzi29, a major CPS expressed by ST258 CR-Kp. The finding that 24D11 also exhibits potent protective efficacy against wzi154 CR-Kp strains highlights its high potential as a lead agent for the development of broadly active immunotherapy. IMPORTANCE Here, we present in vitro and in vivo data for the wzi50 CPS-specific monoclonal antibody MAb 24D11, demonstrating its cross-protective efficacy against three prominent win types (wzi29, wzi154, and wzi50) of the carbapenem-resistant clonal group CG258. In a murine pulmonary infection model, MAb 24D11 reduced bacterial lung burden and dissemination to other organs even if administered 4 h postinfection. Its protective efficacy was also observed in neutropenic mice, which highlights its potential value in clinical settings where oncology patients with CG258 infections may also be neutropenic.
Shaking table tests and numerical analysis of an over-track multi-tower building

Abstract This article aims to investigate the seismic performance of a four-tower (frame-shear wall) building with a large frame podium at bottom sitting on a metro depot through shaking table test and numerical simulations. Technical problems generally exist in this type of buildings due to irregularity in elevation and plan, tower offset, and structural transfer. These problems bring challenges to engineers when analysing and predicting dynamic responses under earthquakes which is crucial for structural safety. To evaluate the seismic performance of the building, a comprehensive study which includes a shake table test of the scaled model and time history analyses using a finite-element model is conducted. The shake table test model is designed based on the similitude law with a 1:40 scale. The dynamic characteristics, cracking pattern, failure mechanism, as well as maximum acceleration and deformation response are investigated. The corresponding finite-element analysis shows a good agreement with experimental results. It is concluded that this type of building can achieve the predefined performance objectives with well-behaved transfer floors. Shear failure at weak story is considered as a main failure mode of the structure. The whipping effect of stories on the top of structure is remarkable. There is no severe damage in steel reinforced concrete beams. Finally, some design suggestions are also proposed to improve the seismic performance of this type of buildings.