Miracle-dz/UniFAR-FTUs huggingface dataset:
microRNA-103 promotes LPS-induced inflammatory injury by targeting c-Myc in HK-2 cells

Abstract Aims microRNAs (miRNAs) occupy a vital position in diseases. This research aims to detect miR-103 influence on LPS-resulted HK-2 cells inflammation damage. Methods Cells were exposed to LPS for inducing injury. CCK-8 and flow cytometry were introduced to detect cell viability and apoptosis rate, respectively. ELISA, qRT-PCR and western blot were respectively used to explore inflammation factors production and relative proteins expression. The relationship between miR-103 and c-Myc was analysed through luciferase reporter assay. Results LPS led to significant inhibition of cell viability (p < .05) and proliferation-related proteins expression. It also increased the apoptosis rate (p < .05) and promoted inflammation cytokines overproduction (p < .001). Besides, miR-103 was elevated by LPS (p < .01), and aggravated LPS-induced damage above, while miR-103 inhibitor attenuated this impairment (p < .05, p < .01 or p < .001). However, c-Myc silence abolished miR-103 inhibitor protective effect on cell proliferation (p < .05), apoptosis (p < .01) and inflammation factors expression (p < .05 or p < .01), representing a negative relationship between them. Besides, the activity of NF-κB as well as JAK/STAT pathways was controlled by miR-103, also, mediated through c-Myc. Conclusions miR-103 mimic enhanced LPS-caused inflammation damage by silencing c-Myc in HK-2 cell line.
Tatarinan T, an α‐asarone‐derived lignin, attenuates osteoclastogenesis induced by RANKL via the inhibition of NFATc1/c‐Fos expression

We have previously reported that the lignin‐like compounds, Tatarinan O (TO) and Tatarinan N (TN), extracted from the roots of Acorus tatarinowii Schott, inhibit receptor activator of nuclear factor‐κB ligand (RANKL)‐induced osteoclastogenesis. In the present study, the potential function of the α‐asarone‐derived lignins, Tatarinan T (TT) and Tatarinan A (TA), to regulate RANKL‐induced osteoclastogenesis was investigated, and it was found that only early treatment with TT may inhibit RANKL‐triggered formation of osteoclasts and resorption. The results revealed repressed expression levels of several osteoclast marker genes, including ATPase H+‐transporting V0 subunit d2 (Atp6v0d2), αvβ3 integrin, and osteoclast‐associated receptor (OSCAR), following TT treatment during osteoclastogenesis. Moreover, TT reduced the expression levels of the core transcription elements, nuclear factor of activated T‐cells cytoplasmic 1 (NFATc1) and c‐Fos. However, western blotting analysis showed that TT treatment did not alter nuclear factor‐κΒ (NF‐κB) activation or mitogen‐activated protein kinase (MAPK) or Syk/Btk/phospholipase Cγ2 (PLCγ2) phosphorylation. Taken together, these results suggest the potential of TT in the treatment of diseases of increased bone resorption.
Polish Adaptation of the Yale Physical Activity Survey: Measurement Properties

The aim of this study was to assess the measurement properties of a Polish adaptation of the Yale Physical Activity Survey (YPAS-PL). The Polish cultural adaptation of the YPAS was administered to a group of 104 people aged 65 to 89 years (mean age 72 ± 5). To assess the reliability of the YPAS-PL, a test-retest procedure was applied. Validity was assessed by comparing the results of the YPAS-PL with accelerometery (ActiGraph wGT3X+). The indicators based on the YPAS-PL activities checklist were characterized by high repeatability and had better reliability values than the YPAS-PL activity dimension indices (energy expenditure interclass correlation coefficient (ICC) = 0.81, total time physical activity ICC = 0.86). We noted a significant positive relationship between energy expenditure measured by an accelerometer and the YPAS-PL (r = 0.23). We can conclude that the YPAS-PL is an adequate tool for assessing energy expenditure related to physical activity in a Polish population of older adults. We also recommend the cautious and well thought-out use of the YPAS-PL activity dimension indices (summary, vigorous, leisurely walking, moving, standing, and sitting indexes).
A CSI-Based Indoor Fingerprinting Localization with Model Integration Approach

Convenient indoor positioning has become an urgent need due to the improvement it offers to quality of life, which inspires researchers to focus on device-free indoor location. In areas covered with Wi-Fi, people in different locations will to varying degrees have an impact on the transmission of channel state information (CSI) of Wi-Fi signals. Because space is divided into several small regions, the idea of classification is used to locate. Therefore, a novel localization algorithm is put forward in this paper based on Deep Neural Networks (DNN) and a multi-model integration strategy. The approach consists of three stages. First, the local outlier factor (LOF), the anomaly detection algorithm, is used to correct the abnormal data. Second, in the training phase, 3 DNN models are trained to classify the region fingerprints by taking advantage of the processed CSI data from 3 antennas. Third, in the testing phase, a model fusion method named group method of data handling (GMDH) is adopted to integrate 3 predicted results of multiple models and give the final position result. The test-bed experiment was conducted in an empty corridor, and final positioning accuracy reached at least 97%.
Disordered Mechanical Stress and Tissue Engineering Therapies in Intervertebral Disc Degeneration

Low back pain (LBP), commonly induced by intervertebral disc degeneration, is a lumbar disease with worldwide prevalence. However, the mechanism of degeneration remains unclear. The intervertebral disc is a nonvascular organ consisting of three components: Nucleus pulposus, annulus fibrosus, and endplate cartilages. The disc is structured to support our body motion and endure persistent external mechanical pressure. Thus, there is a close connection between force and intervertebral discs in LBP. It is well established that with aging, disordered mechanical stress profoundly influences the fate of nucleus pulposus and the alignment of collagen fibers in the annulus fibrosus. These support a new understanding that disordered mechanical stress plays an important role in the degeneration of the intervertebral discs. Tissue-engineered regenerative and reparative therapies are being developed for relieving disc degeneration and symptoms of lower back pain. In this paper, we will review the current literature available on the role of disordered mechanical stress in intervertebral disc degeneration, and evaluate the existing tissue engineering treatment strategies of the current therapies.
Health Behaviors as a Mediator of the Association Between Interpersonal Relationships and Physical Health in a Workplace Context

The etiology of diseases is multifactorial, involving genetic, environmental, and lifestyle-related behaviors. Considering the pathway that involves behavioral processes, a huge body of empirical evidence has shown that some healthy behaviors such as non-smoking, any or moderate alcohol consumption, a healthy diet, (e.g., fruit and vegetable intake), and physical activity, decrease the risk of disease and mortality. This study aimed to explore the potential mediating effect of combined health behaviors on the association between interpersonal relationships and physical health in a Brazilian adult worker population from the Occupational Health Service within the oil industry in Bahia, Brazil. The sample included 611 workers, of which 567 (92.8%) were males and 44 (7.2%) females, age ranging from 18 to 73 years (M = 41.95; SD = 8.88). The significant predictors of physical health were interpersonal relationships and health behaviors. Health behaviors contributed significantly to a reduction in the effect of interpersonal relationships on physical health outcomes. As far as it is known, there has been no prior work in Brazil that simultaneously examined the best predictors of physical health in oil workers using this conceptual model. Interventions in the workplace environment need to consider health behavior as a mediator between interpersonal relationships and physical health, aligned in a global psychosocial approach to health at work.
Grain Scattering Noise Modeling and Its Use in the Detection and Characterization of Defects Using Ultrasonic Arrays

In the field of ultrasonic array imaging for non-destructive testing (NDT), material structural noise caused by grain scattering is one of the main sources of error when characterizing defects that are found in the polycrystalline materials. The existence of grains can also severely affect the detection performance of ultrasonic testing, making small defects indistinguishable from the grain indications due to ultrasonic attenuation and backscatter. This paper proposes a model in which the statistical distribution of the defect data is obtained from different realizations of the grain structure. This statistical distribution, termed the defect+grains model in this paper, is shown to contain information that is needed for detection and characterization of defects. Hence, given a specific measurement configuration, the characterization result can be obtained by constructing a defect+grains model based on the multiple realizations of each possible defect and calculating their probability. The detection, classification, and sizing accuracy are shown to be predictable by quantifying the probabilities that an experimentally measured defect matches the different defect+grains models. This defect+grains modeling approach gives insight into the detection/characterization problem, leading to an evaluation of the fundamental limits of the achievable inspection performance.
Does Disordered Sleep Moderate the Relationship Between Pain, Disability and Downstream Healthcare Utilization in Patients with Low Back Pain? A Longitudinal Cohort from the US Military Health System.

STUDY DESIGN Prospective cohort OBJECTIVE. : The purpose was to evaluate the influence of disordered sleep on the relationship between pain and healthcare utilization (HCU) and pain-related disability and HCU in individuals with low back pain (LBP). SUMMARY OF BACKGROUND DATA Disordered sleep and pain influence low back pain (LBP) outcomes, but their relationship with health care seeking after an episode of LBP has not been investigated and could help identify who is at risk for long-term medical care. METHODS This study included patients with LBP participating in a self-management class at a large US military hospital between 1 March 2010 and 4 December 2012. Pain intensity, disability (Oswestry Disability Index), and sleepiness (Epworth Sleepiness Scale) were captured at baseline. Medical visits for a sleep disorder in the 12 months prior to the class and LBP-related healthcare utilization for the 12 months following the class were abstracted from the Military Health System Data Repository (MDR). Separate multivariate analyses evaluating pain intensity and disability as predictors of HCU were developed, with sleepiness and the presence of a sleep disorder as potential moderators. Analyses were adjusted for age, sex, history of back pain and mental health comorbidities. RESULTS 757 consecutive participants were included, with 195 (26.8%) diagnosed with a subsequent sleep disorder. Sleepiness was not a significant predictor of HCU. The main effects of disability, pain intensity and presence of a sleep disorder were significant across all analyses, with higher disability, pain intensity, and presence of a sleep disorder associated with higher predicted visits and costs for LBP. The presence of a sleep disorder was not a significant moderator in any model. CONCLUSIONS Higher pain intensity and disability predicted higher pain-related HCU in the year following a LBP self-management class. The presence of a sleep disorder diagnosis, as recorded in medical records, had a significant independent effect on LBP-related health care visits and costs beyond the influences of pain intensity, disability, and other key demographic and health-related characteristics, but did not moderate these relationships. LEVEL OF EVIDENCE 3.
Sex and age effects in past-year experiences of violence amongst adolescents in five countries

Purpose To date, there has been insufficient focus on age and sex differences in studies of violence amongst adolescents and young adults in low- and middle-income countries. As adolescence is a formative period during which experiencing violence can have both short- and long-term consequences, we aim to investigate experiences of violence by age and sex across five countries. Methods Incidences of past-year violence victimization were estimated by sex across two-year age bands (13–24 years) using Violence Against Children Survey datasets from Cambodia, Haiti, Kenya, Malawi, and Tanzania. Analyses were conducted separately for each country. The presence of an association with age and each type of violence was identified using logistic regressions separately by sex. Sex was then added to the models as an interaction term and adjusted Wald tests were used to assess differences between males and females in age effects. Results Risk of physical violence by both an adult caregiver and a community member decreased with age for both sexes in all countries. In contrast, risk of IPV increased with age for both sexes in all countries. Although some countries displayed a steeper increase in risk of IPV and sexual violence with age for males, females face higher overall levels of risk for these forms of violence. Conclusion Findings highlight how adolescents’ and young adults’ risk of violence changes with age and type of violence. The analysis underscores the importance of collecting violence data disaggregated by age and sex to best inform policies and programming. Implications and contributions We analyzed five Violence Against Children Surveys (VACS) and found age effects for physical, sexual, and intimate partner violence for adolescents 13–24 years old. Age effects for sexual violence are stronger among females than males. Future policies targeting adolescents should consider how age and gender influence risk of violence.
A Retrospective Study of Transcleral Cyclophotocoagulation Using the Slow Coagulation Technique for the Treatment of Refractory Glaucoma

ABSTRACT Purpose: To compare the success rates and safety of transscleral cyclophotocoagulation (TSCPC) for the treatment of refractory glaucoma using the slow coagulation technique and the conventional technique. Methods: A retrospective, interventional case series of 44 patients (44 eyes) who underwent TSCPC using the slow coagulation technique (22 eyes) and conventional technique (22 eyes) in a tertiary hospital was done. The main outcome measures were success and complications. Success was defined as a final intraocular pressure (IOP) between 6 and 21 mmHg with or without IOP lowering medications with the cessation of oral carbonic anhydrase inhibitor at 12 months. Results: Preoperative characteristics were statistically similar with regard to age, sex, laterality, diagnosis, IOP, and the number of glaucoma medications used. Both procedures had similar success rates of 40.9% and 36.3% in the conventional technique group and slow coagulation group, respectively (p = .757). The slow coagulation group had less prolonged anterior chamber inflammation (p = .048). Conclusions: Diode laser TSCPC using the slow coagulation technique is a safe and effective technique for lowering IOP in patients with refractory glaucoma in Chinese eyes.
The Science Behind Virtual Reality Displays.

Virtual reality (VR) is becoming an increasingly important way to investigate sensory processing. The converse is also true: in order to build good VR technologies, one needs an intimate understanding of how our brain processes sensory information. One of the key advantages of studying perception with VR is that it allows an experimenter to probe perceptual processing in a more naturalistic way than has been possible previously. In VR, one is able to actively explore and interact with the environment, just as one would do in real life. In this article, we review the history of VR displays, including the philosophical origins of VR, before discussing some key challenges involved in generating good VR and how a sense of presence in a virtual environment can be measured. We discuss the importance of multisensory VR and evaluate the experimental tension that exists between artifice and realism when investigating sensory processing. Expected final online publication date for the Annual Review of Virology Volume 6 is September 30, 2019. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
A Systematic Review of Interventions to Reduce the Effects of Cognitive Biases in the Decision-Making of Audiologists

Abstract Background: Audiologists are constantly making decisions that are key to optimizing client/patient outcomes, and these decisions may be vulnerable to cognitive biases. Purpose: The purpose was to determine the present state of knowledge within the field of audiology regarding the potential impact of cognitive biases on clinical decision-making and the use of interventions to reduce such impact. Research Design: A systematic review was conducted to identify and consider the outcomes of all studies in which an intervention, strategy, or procedure was implemented with the aim of reducing the impact of cognitive biases on the decision-making of audiologists. Data Collection: The review was part of a larger scale search which included the broader disciplines of health science and medicine. Electronic database searches were supplemented by citation searches of relevant reviews and a gray literature search. Following title and abstract screening, 201 full-text studies were considered for inclusion. Results: No studies were found which fulfilled the eligibility criteria. Conclusions: Despite initial calls to respond to these types of cognitive biases being made three decades ago, no peer-reviewed scientific studies testing strategies to reduce the impact of cognitive biases on the decision-making of audiologists were found. There is a clear need for a more concerted research effort in this area if audiologists are to consistently deliver truly evidence-based care.
Evaluating the prevalence and quality of conference codes of conduct

Significance Academic conferences encourage collaboration and ignite ideas but can have negative impacts that disproportionately affect historically marginalized groups. Conference codes of conduct can help protect against abuses and foster diversity, but less than one fourth of the biology conferences we studied from the United States and Canada had them. Of these, few codes addressed or denounced identity-based discrimination and sexual misconduct that fuels attrition of scientists from historically marginalized groups. Most codes did not provide clear or impartial reporting mechanisms. Only two thirds listed consequences for violations. We provide recommendations for codes of conduct at biology conferences to improve equity in more platforms of science. Efforts to increase inclusion in science face multiple barriers, including cultural and social behaviors in settings such as academic conferences. Conferences are beneficial, but the culture can promote inequities and power differentials that harm historically underrepresented groups. Science suffers when conference culture propagates exclusion and discrimination that leads to attrition of scientists. Codes of conduct represent a tool to shift conference culture to better support diverse scientists and clearly detail unacceptable behaviors. We examined the prevalence and content of codes of conduct at biology conferences in the United States and Canada. We highlight how codes of conduct address issues of sexual misconduct and identity-based discrimination. Surprisingly, only 24% of the 195 surveyed conferences had codes. Of the conferences with codes, 43% did not mention sexual misconduct and 17% did not mention identity-based discrimination. Further, 26% of these conferences failed to include a way to report violations of the code and 35% lacked consequences for misconduct. We found that larger and national conferences are more likely to have codes than smaller (P = 0.04) and international or regional (P = 0.03) conferences. Conferences that lack codes risk creating and perpetuating negative environments that make underrepresented groups feel unwelcome, or worse, actively cause harm. We recommend that conferences have codes that are easily accessible, explicitly address identity-based discrimination and sexual misconduct, provide channels for anonymous impartial reporting, and contain clear consequences. These efforts will improve inclusivity and reduce the loss of scientists who have been historically marginalized.
Facilitating and Inhibiting Factors for Self-Reports of Same-Gender Attraction in Cisgender Heterosexual-Identifying Women and Men

We sought to identify psychosocial predictors of homoerotic motivations (viz., same-gender attraction) in heterosexual identifying cisgender women and men. We recruited participants from Amazon’s Mechanical Turk to complete measures of (a) antipathy towards lesbians and gay men, (b) gender role beliefs, (c) felt-pressure to conform to gender stereotypes, and (d) openness to experience. In Study 1, we found that same-gender attraction was (a) negatively related to antipathy towards same-gender homosexual targets and (b) positively related to felt-pressure to conform to gender stereotypes for both women and men. In Study 2, both effects replicated for men at p < . 05, but women only showed the antipathy effect at p < . 05, even while the felt-pressure effect size was similar to that in Study 1. Additionally, men showed a significant negative relationship between openness and same-gender attraction. Thus, both anti-gay attitudes and felt-pressure to conform to gender stereotypes appear to be reliably associated with same-gender attraction.
Setting Reading Goals and the Ultimate Achievement of Persian EFL Learners in a Computer-Mediated Environment

This study aimed at investigating the effects of reading goals on L2 reading comprehension in a computer- mediated environment when reading is self-paced by the learners and students are responsible for their own comprehension. Sixty participants (30 males & 30 females) in three groups of 20 were provided with one of three reading goals: read to comprehend the text, read to take a test, and read to teach the material to another student. Then, the participants were asked to read two passages on a computer screen. A computer program, written in C#. NET program, presented the text on the screen four lines at a time, and measured the amount of time students would spend on each page initially, how many times students re-read pages, and how much time students would spend re-reading pages. L2 learners’ comprehension and learning strategies were measured in three ways: recall of materials, time spent reading each page of the text and time spent re-reading pages, and the number of times pages were re-read. Finally, after one month from the first test a posttest was administered to determine which group could remember materials better. The results revealed that recall of materials was significantly greater for the teaching-goal group than the other two groups in both first and second tests. Time spent re-reading was significantly greater for the teaching-goal group as well. These findings suggest that reading goals do have an effect on comprehension and recalling in a computer-mediated environment and students with a different reading goal performed differently while reading passages. This study proposed a way to reduce the burden of teaching on teachers and made the learners responsible for their study. Keywords : reading goals, computer-mediated reading environment, learning, immediate and delayed recall.