Miracle-dz/UniFAR-FTUs huggingface dataset:
Yield Management in the Hotel Industry of Croatia

This paper will explore the profit maximizing method of yield management in the Hotel industry in Croatia. Yield management is a method that enables firms to increase their profits through allocation of their capacities to various customers for the right prices. For Hotels that means selling the rooms at different rate levels. Main goal of this paper is to examine if, and to what extent is the Croatian Hotel industry using this method for profit maximization. After a short theoretical background on yield management we will present the results of empirical research on the implementation of yield management in Hotels in Croatia.
The Possibilities of Additive Manufacturing in Medical Use

Additive Manufacturing has been invented in 1981 at the University of Texas, and to this day it has grown to be the most versatile and promising manufacturing technology in the market, both the industry and health care system has noticed this. Additive Bio-Manufacturing (ABM) techniques, which can be used in health care, are highly in demand, and researches have been going on to make these technologies safer and even more versatile. For more utilization and versatility, special attention is required to develop new materials which can help in increasing the service life, bioactivity, cell growth along with the desired mechanical properties, and to find the right manufacturing parameters for creating optimal products. The aim of this review is to present the available main Additive Manufacturing technologies, and particularly the biomedical usability of Additive Manufacturing.
Evaporation-Induced Water and Solute Coupled Transport in Saline Loess Columns in Closed and Open Systems

Evaporation-induced water and solute coupled transport is a significant cause for soil salinization that leads to a series of engineering and environmental problems. In the artificial evaporation environment, including relative humidity, atmospheric temperature, atmospheric pressure, radiation intensity, and wind speed, evaporation of loess columns with sodium sulfate, temperature profile, and water and solute transport in closed and open systems were investigated. In the former case, a range of stability was noted in the lower part of the column where the heat, water, and solute coupled transport only exhibited a weak response to a specified evaporation environment. As the environment was more favorable for evaporation, or at a higher gradient of temperature, this range extended downwards, while above this range the heat, water, and salt profiles in the evaporation-affected domain changed dramatically, characterized by a basic law that solutes moved with water and were then retained with water desalinated. Evidences were found from the profiles that the water contents in the evaporation-affected range decreased but the salt contents increased, especially in the surface. In an open system, by contrast, there was little difference in temperature but greater in water and salt profiles. Three stages were found from the supply of external water during evaporation. In the initial stage, the higher gradient formed between the initial moisture state and the preset external water level led to a rapid supply of external water. As the evaporation proceeded, a relatively stable water profile was reached as the intensity of water supply approached to that of evaporation, accompanied by a continual migration of solutes towards the surface. Due to the accumulation of precipitated salts, water transport was slowed down, and the intensity of water supply decreased. The changes in soil suction may account for the above behavior.
Mining of Mineral Deposits

Purpose is to elaborate innovative and computationally efficient algorithm to solve a problem of two-stage allocation of the resource occupying continuously the specified area as well as to demonstrate the behaviour of the corresponding software developed with the application of advanced geoinformation resources. Methods. The paper involves mathematical models of continuous problems of optimal set partitioning with additional connections to describe two-stage problems of the material resource location-allocation. Methodological approach to the solution of such problems is based on the idea of their reducing to the problem of infinite-dimensional mathematical programming for which it is possible to obtain optimal solution in the analytical form with the help of the duality theory apparatus. Findings. Mathematical and algorithmic apparatus to solve continuous problems applied for the fuel and energy complex enterprises has been developed making it possible to obtain partitioning of the deposit area into the zones, which are allocated to the first-stage enterprises exclusively. The algorithm operation is demonstrated in terms of the model problem solution. It has been defined that the benefit of such an approach is in the reducing of the infinite-dimensional programming problem to the problem of finite-dimensional nonsmoth optimization since the obtained computational formulas contain the parameters which determination requires solving the auxiliary problem of the nondifferentiable function optimization. Originality. Contrary to the previously developed one, the proposed algorithm does not stipulate solution of the linear programming problem of transport type at each step of the iteration process. Such a problem is solved only once to find the volumes of product transportation between the first-stage and second-stage enterprises after defining all the optimal solution components. Practical implications. Software implementation of the algorithm on the basis of the advanced geoinformation technologies and resources, in terms of the solution of raw material flow allocation, makes it possible to reduce total costs for the management of material flows and their accompanying service flows throughout the whole logistic chain beginning from the flow origin up to its arrival to the end user.
THERAPEUTIC COMPOSITIONS AND METHODS FOR TREATING DSEASE STATES WITH LEUKOCYTE ADHESION

Division of application No. 09/635,899, filed on Aug. 11, 2000, now Pat. No. 6,485,719, which is a con tinuation of application No. 08/943,336, filed on Oct. 3, 1997, now Pat. No. 6,139,832, and which is a continuation-in-part of application No. 08/724,871, filed on Oct. 4, 1996, now abandoned, which is a continuation-in-part of application No. PCT/US96/ 09572, filed on Jun. 5, 1996, and which is a continu ation-in-part of application No. 08/460,987, filed on Jun. 5, 1995, now abandoned, and which is a con tinuation-in-part of application No. 08/464,401, filed on Jun. 5, 1995, now abandoned, and which is a continuation-in-part of application No. PCT/US95/ 01780, filed on Feb. 8, 1995said application applica tion number is a continuation-in-part of application No. PCT/US95/01780, filed on Feb. 8, 1995said application application number is a continuation-in part of application No. PCT/US95/01780, filed on Feb. 8, 1995.
Deformation in shear slitting of polymeric webs

H. Lu, B. Wang, and J. Iqbal Oklahoma State University USA Shear slitting of a 25.4 μm thick polypropylene web was conducted on a laboratory slitter using a pair of rotary blades at a constant speed up to 5.08 mis under controlled tension. The effect of web speed on the slit-edge burr height of the web is investigated for the thick polypropylene web. A profilometer was employed to measure the edge profile. Experimental results indicate that the burr height decreases with web speed when other slitting parameters are fixed. To overcome the difficulty in observing the in-situ shear slitting process of the polypropylene web, a rubber sheet was also used in the present study for the observation of the deformation process during shear slitting, and the surface deformation field of the rubber was measured by a digital image correlation method. The finite element simulation of the early stage of rubber slitting process was performed using commercial ABAQUS code and numerical results are in good agreement with those observed in experiments. The experimental observation and the numerical simulation show that shear slitting of rubber initiates with an indentation process, followed by deformation localizations around the slitter blades; the final stage is a tearing process.
Characterization of acquired receptor tyrosine – kinase fusions as mechanisms of resistance to EGFR tyrosine – kinase inhibitors

Purpose: Responses to EGFR -targeted therapy are generally temporary, due to inevitable drug resistance. The prevalence and characteristics of receptortyrosine – kinase (RTK) fusion as acquired resistance to EGFR tyrosine – kinase inhibitors (TKIs) are rarely investigated. Methods: We retrospectively reviewed genomic pro ﬁ ling data of 3873 EGFR (exons 18 – 21)-mutant lung cancer patients with more than once next-generation sequencing detection. A total of 16 patients who acquired RTK fusions during EGFR-TKI treatment with paired pre- and post-EGFR-TKI samples were identi ﬁ ed. Their treatment history was collected. Results: Newly acquired RTK fusions during EGFR-TKI treatment included RET (n=6, 37.5%), ALK (n=5, 31.3%), NTRK1 (n=4, 25.0%), ROS1 (n=1, 6.3%), and FGFR3 (n=1, 6.3%). All RET and EML4 – ALK fusions were uncommon variants of KIF5B-RET and E2: A20 (V5), respectively. Interestingly, RET fusion occurred only after osimertinib treatment, and contributed to drug resistance in 50% (6 of 12) of patients treated with osimertinib, indicating that fusions had different prevalence when functioning as resistance mechanisms to EGFR TKIs. Moreover, we found that in all patients developing drug resistance to EGFR TKIs due to fusion emergence (n=16), those that had a treatment history of third-generation EGFR TKIs accounted for 75% (n=12). Conclusion: We have extended the current knowledge of resistance mechanisms to EGFR TKIs in non-small-celllung cancer. Detection of RTK fusions should be included in genomic pro ﬁ ling panels to uncover potential resistance mechanisms of EGFR TKIs, which might inform therapeutic strategies, such as combination-therapy approaches, to circumvent tumorigenesis.
The impact of audit-related factors on audit report lag for the Egyptian listed non-financial companies . Dr /

Few studies investigated the determinants of audit report lag in Egypt. This study extends the prior studies by examining the influence of ―auditrelated factors‖, namely audit firm industry specialization, audit tenure, audit fees and joint audit on audit report lag for the Egyptian listed non-financial companies covering the period 20112013. The results indicate that on average, the sampled companies consume 77 days from the end of balance sheet date to the signed audit report date. In addition, by running Ordinary Least Sq-uare (OLS) regression analysis, the fin-dings reveal that, while company size, leverage and qualified auditor report associate positively to a report lag, audit fees, joint audit, audit firm industry specialization, managerial ownership and government ownership associate negatively. Based on the limited literature addressed auditor-related factors in the Egyptian environment, the current study would hold a contribution in terms of investigating the impact of such factors on audit report lag in focused companies.
The impact of customer engagement on service coordination costs in content service:

In order to secure the continuous competitiveness of OTT content services such as YouTube and Netflix, content service SCM promoting the production and distribution of digital information materials is becoming increasingly important. However, previous studies on this are scarce. This study examines the causal relationship between customer engagement, customer response profitability, and service coordination costs from the perspective of a YouTuber, a content creation service provider. In particular, it examines the impact of customer response profitability, a quantitative indicator of customer response, on the use of social media that customers feel and on the relationship between customer engagement and service coordination costs. In this study, we surveyed a YouTuber in Korea, a service provider. SPSS 18, AMOS 20, and PROCESS Macro were used for statistical analysis and hypothesis testing. The analysis shows that the degree of customer engagement on the YouTube channel has a positive effect on customer response profitability and service coordination costs, and that customer response profitability negatively affects service coordination costs (the reduction of costs). The relationship between the customer response profitability and the degree of customer engagement could not be confirmed, but the relationship between customer engagement and the service coordination costs was confirmed. With this study, we contribute to the establishment of policies on the value co-creation framework from the service provider's perspective in content service SCM and on whether to invest in social media in content sourcing.
Exploring the lived experience of Nostalgia as a resource for sociocultural development: A Vygotskian perspective.

Previous quantitative literature highlights a variety of definitions, triggers and functional outcomes of nostalgia but demonstrates noticeable divergence in their attempts to quantify the phenomenon. This research sought to address these issues using a Vygotskian framework that defines nostalgia in terms of an internalised social behaviour that serves as a platform for human development. An IPA methodology was utilised to explore the lived experience of nostalgia in six diverse participants. Three themes were identified: the variation in temporal accessibility of nostalgia within and beyond the lives of individuals; the reciprocal dialogue between personal and cultural accounts of nostalgia and the contextual fluidity of nostalgic experience. These findings illuminated the ways in which previously divisive understandings of nostalgia are better approached holistically and that the recursive, bilateral ontology of the phenomenon indicates that it may be inappropriate to pursue a universally defined comprehension of nostalgia. Epistemological and theoretical implications are discussed.
RANGER: Radars and Early Warning Technologies for Long Distance Maritime Surveillance

In this paper, we present a high-level view of RANGER, a novel platform that combines innovative radar technologies with cutting edge technological solutions for early warning, in view of delivering a surveillance platform offering detection, recognition, identification and tracking of suspicious vessels, i.e. capabilities that exceed those of current radar systems. The RANGER platform consists of two radar technologies, a novel Over-The-Horizon (OTH) Radar combined with a Multipleinput and Multiple-output Radar (MIMO) implemented exploiting the latest photonics advancements, a Uniform Communication Gateway (UCG) for seamless, secure and interoperable integration of radars and legacy systems, an Early Warning System (EWS) exploiting data fusion and deep and adaptable machine learning schemes able to automatically detect radar targets and produce early warnings, an Advanced User Interface (AUI) for visualization of the maritime operational picture, and a Common Information Sharing Environment (CISE) gateway adapter for sharing information with the CISE network. The RANGER system aims at significantly progressing the accuracy and long distance detection, identification and recognition rates as well as improving the provision of early warnings and alerts related to maritime operations, thus drastically improving the response and intervention capacity of related European services.
Vonicog alfa for the treatment of von Willebrand disease

ABSTRACT Introduction: von Willebrand disease (VWD) is the most frequent inherited bleeding disorder. It is caused by the quantitative and/or qualitative abnormalities of von Willebrand factor (VWF), an adhesive protein crucial for platelet-subendothelium interaction and for factor VIII stabilization in plasma. Clinical manifestations are mainly represented by excessive mucocutaneous bleeding and prolonged oozing after surgical procedures. The aim of therapy in VWD is to correct the abnormal platelet adhesion-aggregation as a result of low or dysfunctional VWF and the abnormal intrinsic coagulation owing to low FVIII levels. Current therapeutic options are desmopressin, which releases endogenous VWF from endothelial cells, and exogenous VWF contained in plasma-derived VWF/FVIII concentrates. Areas covered: This paper focuses on the potential therapeutic benefits for VWD of the first recombinant VWF concentrate, vonicog alfa. Topics covered include clinical development, pharmacokinetic profile, safety and efficacy data from Phase 1 and 3 clinical studies of vonicog alpha in patients with clinically severe VWD. Expert opinion: Vonicog alfa may provide advantages in treatment of VWD because it is a recombinant high-purity VWF, with a high efficacy profile when co-administered with FVIII as well as alone. Due to its efficacy even without FVIII, vonicog alfa offers the possibility of a more targeted, personalized replacement therapy based on the needs of each individual patient.
A mutational profile in multiple thymic squamous cell carcinoma.

Background Multiple thymic squamous cell carcinoma (TSCC) is a rare thymic epithelial tumor with a dismal prognosis. Mutational profiles of multiple TSCC may expand our understanding of tumorigenesis and treatment options for these tumors. Methods We sequenced the whole exomes of 3 TSCC nodules from a multiple TSCC patient and a paired peripheral blood sample and identified single-nucleotide variants and small insertions and deletions, and also performed gene ontological and pathway analyses. Results The 3 TSCC nodules were subjected to hematoxylin-eosin staining, and the results showed that these 3 nodules were highly similar with respect to histology. We identified 116, 94 and 98 non-synonymous somatic mutations in the 3 TSCC nodules, and 34 mutations, including mutations in TP53 and ARID1A, among others, were present in all 3 TSCC nodules. We then performed immunohistochemistry to assess two selected genes, TP53 and ARID1A, and found that the 3 TSCC nodules expressed similar levels of TP53 and ARID1A. Further gene ontological analysis and pathway analysis revealed that the 3 TSCC nodules also had similar significantly enriched pathways based on the identified genetic alterations. These results demonstrated that the 3 multiple TSCC nodules were spatially independent of each other but were highly similar with respect to histological sources and genetic characteristics, suggesting that 2 TSCC nodules were likely metastases of the third nodule. Conclusions These findings suggest that TSCC cells can be transferred to other sites inside the thymus and that total thymectomy is a good treatment option for thymic epithelial tumors.
ePubWU Institutional Repository

Gruszka, Katarzyna (2017) Framing the collaborative economy Voices of contestation. Environmental Innovation and Societal Transitions, 23. pp. 92-104. ISSN 2210-4224 This version is available at: https://epub.wu. ac.at/5195/ Available in ePubWU: May 2017 License: Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BYNC-ND 4.0) ePubWU, the institutional repository of the WU Vienna University of Economics and Business, is provided by the University Library and the IT-Services. The aim is to enable open access to the scholarly output of the WU. This document is the version accepted for publication and — in case of peer review — incorporates referee comments. There are differences in punctuation or other grammatical changes which do not affect the meaning.
INVESTIGATION INTO THE BEHAVIOUR AND MODELLING OF CHROMATIC ABERRATIONS IN NON-METRIC DIGITAL CAMERAS

Abstract. Chromatic aberration in colour digital camera imagery can affect the accuracy of photogrammetric reconstruction. Both longitudinal and transverse chromatic aberrations can be effectively modelled by making separate measurements in each of the blue, green and red colour bands and performing a specialized self-calibrating bundle adjustment. This paper presents the results of an investigation with two aims. The first aim is to quantify the presence of chromatic aberration in two sets of cameras: the six individual cameras comprising a Ladybug5 system, calibrated simultaneously in air; and four GoPro Hero 5 cameras calibrated independently under water. The second aim is to investigate the impacts of imposing different constraints in the self-calibration adjustment. To this end, four different adjustment cases were performed for all ten cameras: independent adjustment of the observations from each colour band; combined adjustment of all colour bands’ observations with common object points; combined adjustment of all colour bands with common object points and common exterior orientation parameters for each colour band triplet; and combined adjustment with common object points and certain common interior orientation parameters. The results show that the Ladybug5 cameras exhibit a small (1-2 pixel) amount of transverse chromatic aberration but no longitudinal chromatic aberration. The GoPro Hero 5 cameras exhibit significant (25 pixel) transverse chromatic aberration as well as longitudinal chromatic aberration. The principal distance was essentially independent of the adjustment case for the Ladybug5, but it was not for the GoPro Hero 5. The principal point position and precision were both affected considerably by adjustment case. Radial lens distortion was invariant to the adjustment case. The impact of adjustment case on decentring distortion was minimal in both cases.
Complicated paroxysmal kinesigenic dyskinesia associated with SACS mutations.

Background Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is caused by pathogenic variants in the SACS gene and is characterized by ataxia, peripheral neuropathy, pyramidal impairment and episodic conditions such as epilepsy. Paroxysmal kinesigenic dyskinesia (PKD) had not been previously described in ARSACS. Methods We analyzed clinical manifestations and performed whole-exome sequencing (WES) in two independent patients with ARSACS and PKD. Both patients' parents were unaffected. Genetic data were filtered for potential pathogenic variants, searching for de novo mutations suggestive of a dominant disease model or homozygous and compound heterozygous variants of a recessive model. Potential mutations that existed in both patients were generated and subjected to Sanger sequencing. The WES results of 163 PKD patients without additional symptoms from previous experiments were also reviewed. Results Novel compound heterozygous mutations in the SACS gene were identified in Patient 1 (p.P3007S and p.H3392fs), and a novel homozygous truncating mutation (p.W1376X) was identified in Patient 2. In both patients, each mutant allele was inherited from one of his or her unaffected parents. All 3 mutations were absent in 196 ethnic-matched control chromosomes or in data from the 1000 Genomes Project. No pathogenic variants associated with paroxysmal diseases, especially PKD and episodic ataxia, were identified. In PKD patients without additional symptoms, no homozygous or compound heterozygous variants in the SACS gene were detected. Conclusions This study expands the clinical phenotype of ARSACS and suggests the inclusion of SACS screening in patients with PKD plus ARSACS.