Miracle-dz/UniFAR-FTUs huggingface dataset:
Study on Immune Response of Organs of Epinephelus coioides and Carassius auratus After Immersion Vaccination With Inactivated Vibrio harveyi Vaccine

Immersion vaccination relies on the response of fish mucosa-associated lymphoid tissues, the Crucian carp (Carassius auratus) and Grouper (Epinephelus coioides) were researched in this paper to examine local mucosal immune responses and associated humoral system responses following immersion vaccination. We administered 1.5 × 107 CFU/ml formalin-inactivated Vibrio harveyi cells and measured mucus and serum antibody titers as well as IgM, MHC II mRNA levels in immune organs. The mucosal antibody response preceded the serum response indicating a role for local mucosal immunity in immersion vaccination. IgM and MHC II mRNA levels were relatively greater for the spleen and head kidney indicating the importance and central position of systemic immunity. Expression levels were also high for the gills while skin levels were the lowest. IgM and MHC II mRNA levels were altered over time following vaccination and the hindgut, liver and spleen were similar indicating a close relationship, so the absolute value of r is used to analyze the correlation among different organs immunized. It can be inferred the existence of an internal immune molecular mechanism for Immune synergy hindgut-liver-spleen, from the peak time (14th day), the relative ratio of genes expression in the same tissues between the immunized grouper and the control group (26 times), and Pearson correlation coefficient (0.8<|r|<1). Injection challenges with live V. harveyi indicated that the relative protection rates for the crucian carp and Grouper was basically the same at 44.4% and 47.4%, respectively. It is believe that crucian carp may be used as a substitute for the valuable grouper in immunity experiment, just from aspect of the relative percent survival (RPS) and how it changes with time. But they were not consistent about the IgM mRNA expression between that of crucian carp and grouper after immersion the Vibrio vaccine.
Efficacy and Safety of Qishen Yiqi Dripping Pill for Heart Failure With Preserved Ejection Fraction: A Systematic Review and Meta-Analysis

Background: The number of heart failure with preserved ejection fraction (HFpEF) patients is increasing year by year, yet all western medicines currently used for heart failure have been shown to be ineffective for HFpEF. Qishen Yiqi Dripping Pill is one of the commonly drugs for the treatment of heart failure in China. In recent years, some clinical studies found that it has curative effect on HFpEF. Objective: To evaluate the efficacy and safety of Qishen Yiqi Dripping Pill in treatment of HFpEF. Methods: Databases including CNKI, Wanfang, VIP, CBM, PubMed, Web of Science, The Cochrane Library and EMbase were searched from their inception to May 2020 to screen relevant randomized controlled trials. The “risk of bias” evaluation tool in the Cochrane Handbook was used to evaluate the quality of the included studies. RevMan 5.3 software was used for meta-analysis. Results: Eight studies meeting the criteria were included, with a total of 895 patients. The results of meta-analysis showed that compared with western medicine alone, combination of western medicine and Qishen Yiqi Dripping Pill can further increase the quotient of early diastolic mitral inflow velocity and late diastolic mitral inflow velocity (E/A) in patients with HFpEF [mean difference (MD) = 0.20, 95% CI (0.14, 0.26), p < 0.000 01], decrease the quotient of early diastolic mitral inflow velocity and mitral annular tissue velocity (E/e′) [MD = −2.50, 95% CI (−3.18, −1.82), p < 0.000 01], decrease brain natriuretic peptide (BNP) [MD = −151.83, 95% CI (−245.78, −57.89), p = 0.002], increase cardiac function improvement rate [relative risk (RR) = 1.30, 95% CI (1.11, 1.52), p = 0.001], and increase six-minutes walking distance (6-MWD) [MD = 64.75, 95% CI (22.65, 106.85), p = 0.003]. Four studies reported the occurrence of adverse reactions, among which three studies reported no adverse reactions and one study reported three patients with mild adverse reactions in the intervention group. Conclusion: Current evidence suggests that Qishen Yiqi Dripping Pill may be effective in the treatment of HFpEF. However, due to the low quality of the included studies, lack of placebo control, large heterogeneity among different studies, and great possibility of publication bias, the results of our review should be evaluated with more prudence, more high-quality clinical studies are needed to verify the conclusion in the future. In addition, the safety of Qishen Yiqi Dripping Pill remains uncertain, further assessment is required in the future.
SNFIMCMDA: Similarity Network Fusion and Inductive Matrix Completion for miRNA–Disease Association Prediction

MicroRNAs (miRNAs) that belong to non-coding RNAs are verified to be closely associated with several complicated biological processes and human diseases. In this study, we proposed a novel model that was Similarity Network Fusion and Inductive Matrix Completion for miRNA-Disease Association Prediction (SNFIMCMDA). We applied inductive matrix completion (IMC) method to acquire possible associations between miRNAs and diseases, which also could obtain corresponding correlation scores. IMC was performed based on the verified connections of miRNA–disease, miRNA similarity, and disease similarity. In addition, miRNA similarity and disease similarity were calculated by similarity network fusion, which could masterly integrate multiple data types to obtain target data. We integrated miRNA functional similarity and Gaussian interaction profile kernel similarity by similarity network fusion to obtain miRNA similarity. Similarly, disease similarity was integrated in this way. To indicate the utility and effectiveness of SNFIMCMDA, we both applied global leave-one-out cross-validation and five-fold cross-validation to validate our model. Furthermore, case studies on three significant human diseases were also implemented to prove the effectiveness of SNFIMCMDA. The results demonstrated that SNFIMCMDA was effective for prediction of possible associations of miRNA–disease.
Determinants of Frequent Attendance in Primary Care. A Systematic Review of Longitudinal Studies

Introduction: There is a lack of a systematic review synthesizing longitudinal studies investigating the determinants of frequent attendance in primary care. The goal of our systematic review was to fill this gap in knowledge. Methods: Three electronic databases (Medline, PsycINFO, and CINAHL) were searched. Longitudinal observational studies analyzing the predictors of frequent attendance in primary care were included. Data extraction covered methods, sample characteristics, and main findings. Selection of the studies, extracting the data and evaluation of study quality was performed by two reviewers. In the results section, the determinants of frequent attendance were presented based on the (extended) Andersen model. Results: In total, 11 longitudinal studies have been included in our systematic review. The majority of studies showed that frequent attendance was positively associated with the predisposing characteristics lower age, and unemployment. Moreover, it was mainly not associated with enabling resources. Most of the studies showed that need factors, and in particular worse self-rated health, lower physical functioning and physical illnesses were associated with an increased likelihood of frequent attendance. While most studies were of good quality, several of the included studies did not perform sensitivity analysis or described how they dealt with missing data. Discussion: Our systematic review showed that particularly lower age, unemployment and need factors are associated with the likelihood of becoming a frequent attender. Enabling resources are mainly not associated with the outcome measure. Future research should concentrate on the determinants of persistent frequent attendance due to the high economic burden associated with it.
Combining and converting groups when extracting data for meta-analysis

such as which will be presented as mean and SD, and categorical variables, such as diabetic status, which will be reported as the number and percentage of patients with diabetes. For meta-analysis of continuous outcomes, the required data from each study and for each treatment group are the mean and standard deviation (SD) of the outcome measure, and the number of participants. Note that this implies normally distributed data.
Outcomes of patients with cervical cancer treated with low- or high-dose rate brachytherapy after concurrent chemoradiation

Objective The majority of patients with cervical cancer in Ghana present with locally advanced disease. In October 2014, high-dose rate (HDR) brachytherapy was introduced at the National Center for Radiotherapy, Accra after years of using low-dose rate (LDR) brachytherapy. The aim of this study was to compare the treatment outcomes of patients treated with LDR versus HDR brachytherapy. Methods Patients with cervical cancer treated from January 2008 to December 2017 were reviewed. Those with stage IB–IIIB who received chemoradiation plus brachytherapy were included in the study. Post-operative patients and those with stage IV were excluded. The study end points were local control, disease-free survival, and overall survival at 2 years. Endpoints were estimated using the Kaplan–Meier method. Comparisons between treatment groups were performed using the log-rank test and Cox proportional hazards model. Results We included 284 LDR and 136 HDR brachytherapy patients. For stages IB, IIA, IIB, IIIA and IIIB disease, the 2-year local control for LDR versus HDR brachytherapy was 63% and 61% (p=0.35), 86% and 90% (p=0.68), 86% and 88% (p=0.83), 66% and 60% (p=0.56), and 77% and 40% (p=0.005), respectively. The 2-year disease-free survival for LDR versus HDR brachytherapy was 64% and 61% (p=0.50), 81% and 69% (p=0.18), 81% and 80% (p=0.54), 62% and 33% (p=0.82), and 71% and 30% (p=0.001) for stages IB, IIA, IIB, IIIA, and IIIB, respectively. The 2-year overall survival for LDR versus HDR brachytherapy was 94% and 93% (p=0.92), 98% and 68% (p=0.21), 89% and 88% (p=0.60), and 88% and 82% (p=0.34) for stages IB, IIA, IIB, and IIIB disease, respectively. Conclusion There was no difference between LDR and HDR brachytherapy in local control and disease-free survival for all stages of disease, except in stage IIIB. These findings highlight the need to refine this brachytherapy technique for this group of patients.
Structural effects on the nano-scale morphology and conductivity of ionomer blends

The role of graft and diblock ionomer architecture on the morphology and properties of ionomer/fluoropolymer blends is examined. The graft copolymer consists of a partially fluorinated backbone of P(VDF-co-CTFE) and partially sulfonated polystyrene (PS) side chains while the diblock copolymer consists of a block of P(VDF-co-HFP) and a partially sulfonated PS block. These ionomers are blended with fluoropolymers possessing a chain length that matches the average sequence length of the fluorous block segment of the ionomer. The results from this study are surprising: graft ionomers are primarily insensitive to blending due to the incorporation of the non-ionic fluorous polymers into the domains of the perfluorinated backbone which does not deleteriously affect the interconnecting proton conducting ionic clusters. In contrast, diblock ionomers are highly sensitive to the addition of fluoropolymers and despite the observation that ionic channels are retained, water sorption is decreased due to the increased volume of the non-ionic domains, which decreases proton mobility and proton conductivity.
Study of the Adsorption Thermodynamics and Kinetics of Lipoic Acid onto Three Types of Resin

The adsorption of lipoic acid on three different types of resin was compared. Studies of the adsorption thermodynamics and kinetics of lipoic acid onto XAD-4, NDA-100 and ND-90 resins were carried out via static experiments. The results showed that the polar groups and micropore ranges associated with the resins played a significant role in the adsorption of lipoic acid. Such processes were exothermic and involved physical adsorption. The adsorption of lipoic acid onto XAD-4 resin corresponded to the formation of a Langmuir monolayer, with the adsorption velocity appearing to follow first-order kinetics. The adsorption data of lipoic acid onto NDA-100 and ND-90 resins were also well fitted by the Langmuir isotherm, which was associated with capillary condensation and volume filling of micropores besides monolayer adsorption. In contrast, the adsorption of lipoic acid onto NDA-100 and ND-90 resins involved two pore ranges: macropore + mesopore and micropore. The adsorption velocities for the two ranges followed first-order kinetics.
Sodium alginate microspheres containing multicomponent inclusion complex of domperidone

SUMMARY. Sodium alginate microspheres of domperidone for intranasal systemic delivery were developed to eliminate first pass metabolism, improve patient compliance and obtain improved therapeutic efficacy in treatment of migraine, gastro-esophageal reflux and chemotherapy induced nausea and vomiting. Domperidone was encapsulated as ternary inclusion complex with β-cyclodextrin and citric acid to improve solubility. The phase solubility studies were performed in order to select suitable acid and ternary inclusion complex was prepared by kneading method. The complex was characterized by differential scanning calorimetry, X-ray diffraction and Fourier transform infrared spectroscopy. In vitro dissolution study was carried out in simulated nasal electrolyte solution, pH 6.4. The microspheres of optimised ternary inclusion complex were prepared by emulsification-cross-linking method and were evaluated for particle size, encapsulation efficiency, equilibrium swelling degree, in vitro mucoadhesion and in vitro drug release. The effect of various formulation variables such as drug loading, polymer concentration, crosslinking agent concentration and cross-linking time on microsphere characteristics were studied. The microspheres size range was 57.63-65.3 μm, whereas the percentage drug encapsulation was within the range 15-50 %. All microspheres showed good bioadhesive properties. The formulation variables influenced the drug release profile. The treatment of in vitro release kinetics with kinetic equations indicated that the domperidone release followed Higuchi’s matrix model.
Quantitative Proteinbestimmung im Harn mit dem Proteinbindungsfarbstoff Coomassie Brilliant Blau G250

Summary: Coomassie Brilliant Blue G250 was used for the determination of total urinary protein and compared with the biuret-procedure. In the Coomassie Brilliant Blue G250-assay 0.10 ml urine are added to 5.0 ml Coomassie Brilliant Blue G250 reagent and the sample is read against the reagent blank. The Coomassie Brilliant Blue G250 method seems to be superior to the biuret-procedure because of better reproducibility, higher sensitivity and simpler handling. The upper limit of urinary protein excretion in 49 healthy subjects was 120 mg/24 h. To evaluate the clinical significance of the Coomassie Brilliant Blue G250 method the urinary protein concentration of 134 patients with metabolic, systemic and organ diseases was compared with the biuret-procedure. The regression line was y = 0.827 + 8.713 mg/1 with a correlation coefficient of r = 0.966. The type of proteinuria (mixed, glomerular, tubular) had no influence on the protein value measured with the Coomassie Brilliant Blue G250 method. However in selective proteinuria, like Bence-Jones protein excretion, there is no correlation between the two methods, because the concentration of Bence-Jones protein is underestimated. Lower protein values were also frequently obtained for patients with diabetes rhellitus. Some specimens from patients with chronic renal failure treated by haemodialysis showed elevated values. In spite of these limitations the Coomassie Brilliant Blue G250 method might become the method of choice for the determination of total urinary protein.
Wind speed time series characterization by Hilbert transform

Predictions of wind energy potential in a given region are based on on‐location observations. The time series of these observations would later be analysed and modelled either by a probability density function (pdf) such as a Weibull curve to represent the data or recently by soft computing techniques, such as neural networks (NNs). In this paper, discrete Hilbert transform has been applied to characterize the wind sample data measured on İzmir Institute of Technology campus area which is located in Urla, İzmir, Turkey, in March 2001 and 2002. By applying discrete Hilbert transform filter, the instantaneous amplitude, phase and frequency are found, and characterization of wind speed is accomplished. Authors have also tried to estimate the hourly wind data using daily sequence by Hilbert transform technique. Results are varying. Copyright © 2005 John Wiley & Sons, Ltd.
Experimental study on incorporation of C-H-O-N fluid components in Mg-cordierite

Experiments on cordierite saturation with “dry” methane, ammonia and the components of H 2 O-CH 4 and H 2 O-NH 3 binary mixtures were performed at 50, 150, 200 MPa in the temperature range from 400 to 800°C to examine the possibility of using Mg-cordierite as an indicator of fluid regime in mineral genesis. We checked that the starting product was free from fluid components at the sensitivity level of the IR and chromatographic methods. Powders with particle size 25–50 μ were used. The run time was 300 h in all the experiments. The typical bands observed in the IR and Raman spectra demonstrate the presence of fluid molecules in the channels. The partition coefficients of CH 4 , NH 3 , and H 2 O between the fluid phase and Mg-cordierite are temperature independent according to the mass spectrometry data. In “dry” systems, small quantities of H 2 O (up to 0.6 mol.%) are formed by reactions between ammonia and the framework oxygen of the cordierite structure. Thus, the occurrence of water in the structural channels of cordierite does not always mean that water is present in the fluid.
Numerical Analysis of Wall Characteristics for Turbulent Swirling Jets Impinged on a Concave Surface

Impingement jets systems provide an effective method for achieving particularly high heat transfer coefficient. Whilst a significant amount of studies are available for flat surfaces, the flow and thermal performance for curved surface is limited in the literature. As such, a numerical study using finite volume method is conducted to investigate the wall behaviors, such as pressure, friction and heat transfer characteristics along the concave surface. In this regard, both non-swirling and swirling jets are considered in the range (S = 0 – 0.72) for a Reynolds number equals to 11,000 at various dimensionless nozzle-to-impingement surface distances (4.5 ≤ H/D ≤ 7.5). The Reynolds-averaged momentum and energy equations are solved together, with turbulence described by a two-equation turbulence model, such as the k-ε model. The simulation data is first compared with the literature for non-swirling jets on curved surface and the data agrees with convincing accuracy. The results of this study show the effects of the surface characteristics of non-swirling and swirling jets significantly depend on both the swirl effect and the impingement distance.
Sensitivity of aerosol direct radiative forcing to aerosol vertical profile

Aerosol vertical profile significantly affects the aerosol direct radiative forcing at the TOA level. The degree to which the aerosol profile impacts the aerosol forcing depends on many factors such as presence of cloud, surface albedo and aerosol single scattering albedo (SSA). Using a radiation model, we show that for absorbing aerosols (with an SSA of 0.7–0.8) whether aerosols are located above cloud or below induces at least one order of magnitude larger changes of the aerosol forcing than how aerosols are vertically distributed in clear skies, above cloud or below cloud. To see if this finding also holds for the global average aerosol direct radiative effect, we use realistic AOD distribution by integrating MODIS, MISR and AERONET observations, SSA from AERONET and cloud data from various satellite observations. It is found that whether aerosols are above cloud or below controls about 70–80% of the effect of aerosol vertical profile on the global aerosol radiative effect. Aerosols below cloud contribute as much to the global aerosol radiative effect as aerosols above cloud.
Novel BiFeO3–BaTiO3–Ba(Mg1/3Nb2/3)O3 Lead-Free Relaxor Ferroelectric Ceramics for Energy-Storage Capacitors

A novel lead-free relaxor ferroelectric ceramic of (0.67−x)BiFeO3–0.33BaTiO3–xBa(Mg1/3Nb2/3)O3 [(0.67−x)BF–0.33BT–xBMN, x = 0–0.1] was prepared by a solid-state reaction method. A relatively high maximum polarization Pmax of 38 μC/cm2 and a low remanent polarization Pr of 5.7 μC/cm2 were attained under 12.5 kV/mm in the x = 0.06 sample, leading to an excellent energy-storage density of W ~1.56 J/cm3 and a moderate energy-storage efficiency of η ~75%. Moreover, a good temperature stability of the energy storage was obtained in the x = 0.06 sample from 25°C to 190°C. The achievement of these characteristics was basically attributed to an electric field induced reversible ergodic to ferroelectric phase transition owing to similar free energies near a critical freezing temperature. The results indicate that the (0.67−x)BF–0.33BT–xBMN lead-free realxor ferroelectric ceramic could be a promising dielectric material for energy-storage capacitors.
Weibull Parameters Estimation Using Four Different Methods and Most Energy-Carrying Wind Speed Analysis

The study presents the analysis of wind speed data from seven stations in Saudi Arabia, measured at 20, 30, and 40 m height above ground level (AGL) over a period varying from 2 to 5 years. Specifically, Weibull parameters were calculated using five different methods, four of them based on the statistical analysis of the collected data and a fifth one based on WAsP algorithm used in WindoGrapher software. The calculated values using the five different methods were found to be in good agreement at all the measurement heights. The correlation between the monthly mean values of Weibull scale parameter and the measured wind speed values was found to be linear for all the sites. The linear coefficient ‘a’ was found to be site's characteristic value and independent of the height AGL for most of the locations. Moreover, linearity has been substantiated between the monthly mean wind power density (WPD) and the corresponding measured wind speed for all the stations, with linear coefficients ‘a’ directly proportional to height AGL. Finally, the values of Weibull shape parameter (k) were found to be independent of height AGL, while that of scale parameter (c) varying with height.
A Platform for Extracting Driver Behavior from Vehicle Sensor Big Data

Traffic analysis of vehicles in densely populated areas and places of public gathering can provide interesting insights into crowd behavior. Hajj is a spatio-temporally bound religious activity that is held annually and attended by more than 2 million people. More than 17,000 buses are used to transport pilgrims on fixed days to fixed locations. This poses great challenges in terms of crowd management. Using Global Positioning System (GPS) and Automatic Vehicle Location (AVL) sensors attached to buses, a large amount of spatiotemporal vehicle data can be collected for traffic analysis. In this paper, we present a study whereby driver behavior was extracted from an analysis of vehicle big data. We have explained in detail how we collected data, cleaned it, moved it to a big data repository, processed it and extracted information that helped us characterize driver behavior according to our definition of aggressiveness. We have used data from 17,000 buses that has been collected during Hajj 2018. Keywords—GPS Data; AVL sensors; hajj; big data; traffic analysis