Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychometric Properties of the Lasater Clinical Judgment Rubric

Abstract Simulation is integrated into nursing curricula as a means of developing and evaluating clinical judgment, but there are few valid and reliable tools available and evaluation is not consistently theory based. When the Lasater Clinical Judgment Rubric (LCJR) was introduced in 2007, it provided a common evaluative language for assessment of clinical judgment but had limited support of its validity and reliability. Based on Tanner’s Model, the LCJR organized nursing actions into eleven dimensions and four behavioral categories and defined specific actions in each which are typical of developmental phases (Lasater, 2007). The LCJR has been adopted by many nursing programs with limited support of its validity and reliability. This article attempts to organize current knowledge available on the LCJR in an effort to assess its use as a valid and reliable measurement tool, and to identify specific needs for continued testing of the instrument.
Compact Modeling of Junction Current in Dynamically Depleted SOI MOSFETs

We report the compact modeling of junction current in dynamically depleted silicon-on-insulator (SOI) MOSFETs. The body-to-source built-in barrier lowering is obtained from the coupled surface potential equations which serve as the basis of surface-potential-based SOI MOSFET models. This barrier lowering is then incorporated into the advanced junction model to enable the unification of junction current in partially depleted and fully depleted SOI MOSFET models. Compared with 2-D TCAD simulations, the characteristics of body-to-source/drain junction current in dynamically depleted SOI MOSFETs are faithfully reproduced by the new approach.
Vaccine Therapy for Murine Glioma Using Tumor Cells Genetically Modified to Express B7.1

OBJECTIVEIn a syngeneic mouse brain tumor model, we tested the hypothesis that vaccination with tumor cells genetically modified to express B7.1 molecules induces tumor-specific T cells and immunological antitumor effects. METHODSMalignant glioma cells (RSV-MG) derived from a C3H/He mouse induced by Schmidt-Ruppin Rous sarcoma virus (RSV) were infected with an adenovirus encoding the B7.1 gene (AdB7). To investigate the effects of B7.1 expression on the tumorigenicity of RSV-MG cells, infected cells were implanted subcutaneously into C3H/He mice. The C3H/He mice were vaccinated with AdB7 transfectants injected subcutaneously and 2 weeks later were challenged intracerebrally with wild-type RSV-MG cells to determine whether or not the expression of B7.1 would enhance the immunogenicity of RSV-MG cells. RESULTSImmunocytochemistry confirmed the expression of B7.1 and major histocompatibility complex Class I antigen on the infected cells. The growth of subcutaneous tumors was markedly retarded in the AdB7 group, whereas tumors had formed and progressively increased in size in the other control groups. In the vaccine experiments, the mice immunized with AdB7 transfectants survived longer than did the mice of the other groups, and a significant difference in survival times was noted. Immunocytochemistry revealed that brain tumors in mice previously vaccinated with AdB7 infectants had been infiltrated by a larger number of CD3+ lymphocytes and that these CD3+ lymphocytes contained not only CD4+ and CD8+ T cells but also CD25+-activated T cells. In addition, a cytotoxicity assay confirmed that vaccination with the AdB7 transfectants induced tumor-specific cytotoxicity. CONCLUSIONThese results demonstrate the therapeutic potential of vaccination with tumor cells expressing B7.1 for the treatment of malignant glioma.
Relationship of pulmonary artery catheter use to mortality and resource utilization in patients with severe sepsis*

ObjectiveTo examine the relationship of pulmonary artery catheter (PAC) use to patient outcomes, including mortality rate and resource utilization, in patients with severe sepsis in eight academic medical centers. DesignCase-control, nested within a prospective cohort study. SettingEight academic tertiary care centers. PatientsStratified random sample of 1,010 adult admissions with severe sepsis. InterventionsNone. Measurements and Main ResultsThe main outcome measures were in-hospital mortality, total hospital charge, and length of stay (LOS) for patients with and without PAC use. The case-matched subset of patients included 141 pairs managed with and without the use of a PAC. The mortality rate was slightly but not statistically significantly lower among the PAC use group compared with those not using a PAC (41.1% vs. 46.8%, p = .34). Even this trend disappeared after we adjusted for the Charlson comorbidity score and sepsis-specific Acute Physiology and Chronic Health Evaluation (APACHE) III (adjusted odds ratio, 1.02; 95% confidence interval, 0.61–1.72). In linear regression models adjusted for the Charlson comorbidity score, sepsis-specific APACHE III, surgical status, receipt of a steroid before sepsis onset, presence of a Hickman catheter, and preonset LOS, no significant differences were found for total hospital charges (US$139,207 vs. 148,190, adjusted mean comparing PAC and non-PAC group, p = .57), postonset LOS (23.4 vs. 26.9 days, adjusted mean, p = .32), or total LOS in intensive care unit (18.2 vs. 18.8 days, adjusted mean, p = .82). ConclusionsAmong patients with severe sepsis, PAC placement was not associated with a change in mortality rate or resource utilization, although small nonsignificant trends toward lower resource utilization were present in the PAC group.
A novel voltage sensorless DPC approach of AFE rectifier based on virtual flux and dynamic DC link reference design

In this work, a novel voltage sensorless Direct Power Control (DPC) approach of Active Front End (AFE) rectifier based on virtual flux and dc-link dynamic reference design technique is presented. Firstly, the PI controller is eliminated from the outer dc-link voltage control loop with the application of dynamic dc-link reference design technique and line voltage sensors by using virtual flux technique. Further, a simple way to obtain the dc-link voltage based on the switching states of the rectifier is implemented to remove the outer loop voltage sensor also and hence the voltage sensorless DPC approach has achieved. Finally, the Experimental results of both the approaches, one with dc-link voltage sensor but without PI controller and another with the absence of both PI controller and dc-link voltage sensor is presented. Numerical experimental results depict the better control from the proposed techniques regarding reduction in active, reactive power ripple and THD in the line current.
Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator

In budding yeast, the monopolin complex mediates sister kinetochore cross‐linking and co‐orientation in meiosis I. The CK1δ kinase Hrr25 is critical for sister kinetochore co‐orientation, but its roles are not well understood. Here, we present the structures of Hrr25 and its complex with the monopolin subunit Mam1. Hrr25 possesses a “central domain” that packs tightly against the kinase C‐lobe, adjacent to the binding site for Mam1. Together, the Hrr25 central domain and Mam1 form a novel, contiguous embellishment to the Hrr25 kinase domain that affects Hrr25 conformational dynamics and enzyme kinetics. Mam1 binds a hydrophobic surface on the Hrr25 N‐lobe that is conserved in CK1δ‐family kinases, suggesting a role for this surface in recruitment and/or regulation of these enzymes throughout eukaryotes. Finally, using purified proteins, we find that Hrr25 phosphorylates the kinetochore receptor for monopolin, Dsn1. Together with our new structural insights into the fully assembled monopolin complex, this finding suggests that tightly localized Hrr25 activity modulates monopolin complex–kinetochore interactions through phosphorylation of both kinetochore and monopolin complex components.
A 100-element HBT grid amplifier

A 100-element 10-GHz grid amplifier has been developed. The active devices in the grid are chips with heterojunction bipolar transistor (HBT) differential pairs that include a resistive network to provide self-bias to the base. The planar metal grid structure was empirically designed to provide effective coupling between the HBTs and free space. Two independent measurements, one with focusing lenses, the other without, were used to measure the gain of the grid. In each case the peak gain of the grid was 10 dB at 10 GHz with a 3-dB bandwidth of 1 GHz. The input and output matches are better than 15 dB at 10 GHz. The maximum output power is 450 mW, and the minimum noise figure is 7 dB. Tests show that the grid is quite tolerant of failures-the output power dropped by only 1 dB when 10% of the inputs were detuned. The device amplifies beams with incidence angles up to 30 degrees with less than a 3-dB drop in power. <<ETX>>
Current practices in depression care

&NA; Despite improved awareness among the medical community concerning common mental health disorders, the high prevalence of depression in the United States remains unchanged1 and has been compounded by increasing evidence of gaps in mental health care for ethnic and racial minorities.1,2 Thus, there is a strong need for the timely creation of comprehensive educational initiatives aimed at improving the quality of care provided by mental health professionals and primary care physicians. Fundamental to this process is the examination of current treatment standards, as well as identification of practices that require improved physician education. Consistent use of appropriate screening tools, diagnostic accuracy and timeliness, continual assessment of illness severity, adherence to practice guidelines, and individualized patient care need heightened attention to improve outcomes. This article describes the most prevalent types of depression and summarizes current practices in depression care, with an emphasis on treatment standards and opportunities for improved performance.
Executive function and Language Learning: Differentiating Vocabulary and Morpho-Syntax

In recent years, the debate around the relationship between executive control and bilingual language proficiency has extended to the investigation of the role of the former in second language learning. The present study is based on data collected from 20 native and near-native adult speakers of English and investigated the relationship between the learning of Brocanto2, an artificial language with a complex morpho-syntax, and two measures of executive function - cognitive flexibility and inhibitory control. Although the result of the present study did not support the existence of a significant relationship between executive function and the acquisition of L2 morpho-syntax, they confirmed the role of vocabulary learning as a factor possibly driving the correlations between language learning and executive function found in previous studies.
2 Fuzzing the Heartbleed-Introducing Source Code Commit

Existing Greybox Fuzzers (GF) cannot be effectively directed, for instance, towards problematic changes or patches, towards critical system calls or dangerous locations, or towards functions in the stacktrace of a reported vulnerability that we wish to reproduce. In this paper, we introduce Directed Greybox Fuzzing (DGF) which generates inputs with the objective of reaching a given set of target program locations efficiently. We develop and evaluate a simulated annealing-based power schedule that gradually assigns more energy to seeds that are closer to the target locations while reducing energy for seeds that are further away. Experiments with our implementation AFLGo demonstrate that DGF outperforms both directed symbolic-execution-based whitebox fuzzing and undirected greybox fuzzing. We show applications of DGF to patch testing and crash reproduction, and discuss the integration of AFLGo into Google’s continuous fuzzing platform OSS-Fuzz. Due to its directedness, AFLGo could find 39 bugs in several well-fuzzed, security-critical projects like LibXML2. 17 CVEs were assigned.
Wnt Signaling Protects 3T3-L1 Preadipocytes from Apoptosis through Induction of Insulin-like Growth Factors*

Ectopic expression of Wnt-1 in 3T3-L1 preadipocytes stabilizes β-catenin, activates TCF-dependent gene transcription, and blocks adipogenesis. Here we report that upon serum withdrawal, Wnt-1 causes 3T3-L1 cells to resist apoptosis through a mechanism that is partially dependent on phosphatidylinositol 3-kinase. Although activation of Wnt signaling by inhibition of GSK-3 activity or ectopic expression of dominant stable β-catenin blocks apoptosis, inhibition of Wnt signaling through expression of dominant negative TCF-4 increases apoptosis. Wnt-1 stimulates 3T3-L1 preadipocytes to secrete factors that increase PKB/Akt phosphorylation at levels comparable with treatment with 10% serum. With DNA microarrays, we identified several secreted antiapoptotic genes that are induced by Wnt-1, notably insulin-like growth factor I (IGF-I) and IGF-II. Consistent with IGFs mediating the antiapoptotic effects of Wnt-1 in preadipocytes, conditioned medium from Wnt-1 expressing 3T3-L1 cells was unable to promote protein kinase B phosphorylation after the addition of recombinant IGFBP-4. Thus, we demonstrated that Wnt-1 induces expression of antiapoptotic genes in 3T3-L1 preadipocytes such as IGF-I and IGF-II, which allows these cells to resist apoptosis in response to serum deprivation.
Employing Kullback-Leibler divergence and Latent Dirichlet Allocation for fraud detection in telecommunications

In this paper, a method for telecommunications fraud detection is proposed. The method is based on the user profiling using the Latent Dirichlet Allocation LDA. Fraudulent behavior is detected with use of a threshold-type classification algorithm, allocating the telecommunication accounts into one of two classes: fraudulent account and non-fraudulent account. The paper provides also a method for automatic threshold computation. The accounts are classified with use of the Kullback-Leibler divergence KL-divergence. Therefore, we also introduce three methods for approximating the KL-divergence between two LDAs. Finally, the results of experimental study on KL-divergence approximation and fraud detection in telecommunications are reported.
Characterizing User Behavior in a European Academic WiFi Network

Wireless local area networks WLANs are commonplace in many universities. Understanding the trends in the usage of these networks is becoming more important. Interesting results can be extracted about association patterns by analyzing WLAN traces from real scenarios. In this work, the library in the main campus of the Technical University of Catalonia UPC in Barcelona has been studied. Daily and weekly patterns of the WLAN connections are shown. The population accessing the network is mostly composed of infrequent users: half of the population accesses the WLAN once during each month. Many users associate to only one of the twelve possible access points, which means that, despite the widespread use of lightweight devices, many users are static. The results of this analysis provide general tools for characterizing campus-wide WLAN and a better understanding of usage and performance issues in a mature wireless network.
Effect of Curcumin Supplementation on Hepatic, Renal and Intestinal Organization of Anabas testudineus (Bloch): Light and Electron Microscopic Studies

The ultrastructure of hepatic, renal and intestinal tissues of Anabas testudineus and the influence of dietary curcumin (0.5 and 1% for 6 months) on the organization of these tissues were studied. The results revealed an increased vascularity in curcumin-treated fish liver. The size of hepatopancreas and its nuclei and melanomacrophage centres increased in the treated liver while size of hepatocytes and their nuclei remained unchanged. The hypertrophy and hyper-activity of hepatopancreas might provide for proper digestion and absorption of food. In the intestine, the number of goblet's cells in the villi decreased in the curcumin treated group which might help the retention of food in the intestine. Therefore, based on the above results it can be concluded that curcumin is beneficial to fish and, so, could be of application in aquaculture practices.
Developing A Breathlessness Intervention Service for Patients with Palliative and Supportive Care Needs, irrespective of Diagnosis

than air as a palliative intervention for cancer dyspnea. Oxygen and air from a mask (cooling the face) possibly reduced breathlessness slightly and equally. In 1987, Schwartzstein, Lahive, and Pope published evidence demonstrating that facial cooling could reduce the sensation of breathlessness induced in normal volunteers (5), so using a fan to reduce disease-related breathlessness began to gain credence. The oxygen-versus-air trial was completed with patients breathless at rest; preparation for the study had shown a paucity of appropriate outcome measures for dyspnea. A subsequent validation study of the Shuttle Walking Test (6) as an outcome measure for breathlessness in mobile patients attending a hospice day centre revealed, unexpectedly, that hospice patients valued exercise, given the opportunity. Rehabilitation for patients with advanced cancer was not then usual practice; it was even seen as possibly detrimental to these fatigued individuals. From the 1970s onward, there was growing research evidence that exercise was an effective palliation for breathlessness (7). It was provided as part of a multi-professional rehabilitation pro gram (pulmonary rehabilitation, or PR) com bining education, psychosocial approaches, and group support. At first, it was only offered to patients with chronic obstructive pulmonary disease (COPD) in specialist centres. Jennings and colleagues’ important systematic review of opioids had not yet been published (8), and the use of opioids for breathlessness was sporadic, except with cancer patients at the end of life, for whom it was routine palliative medicine. Given the evidence from the respiratory medicine literature on the value of exercise and a multiprofessional rehabilitative approach to reducing Developing a Breathlessness Intervention Service for Patients with Palliative and Supportive Care Needs, Irrespective of Diagnosis
Transcranial Light Alters Melanopsin and Monoamine Production in Mouse ( Mus musculus ) Brain

Background: The mammalian circadian system sets a rhythm for the appropriate occurrence of physiological and behavioral phenomena during a 24-h period. Since the duration of the circadian system is usually less or more than 24 h, it must be entrained regularly and light is the governing stimulus of the rhythm. The target for light stimulus is the master circadian clock, which is located in the suprachiasmatic nucleus in the hypothalamus. One of the key molecules transmitting light information and entraining the clock is melanopsin (OPN4), a G protein-coupled molecule that is found most abundantly in the retina and brain. Although light stimulus is usually mediated through the eyes, light has an ability to penetrate the skull. Here, we present the effect of transcranial light illumination on OPN4 and serotonin expression in the mouse brain. Methods: Male mice were randomly assigned to a control group, morning-light group and evening-light group, and animals were illuminated transcranially five times a week for 8 min for a total of 4 weeks. The concentrations of OPN4 and monoamines were analyzed with Western blot and high-performance liquid chromatography (HPLC) techniques, respectively. Results: Our results show that transcranial light illumination increases the amount of OPN4 in the hypothalamus and cerebellum. Additionally, the production of serotonin in the cortex was shown to decrease in the morning-light group. Conclusions: With this study, we provide novel information on the effects of light administration through the skull on transmitters regulating circadian rhythmicity by showing that transcranial light affects molecules involved in circadian rhythmicity. J Neurol Res. 2017;7(3):39-45 doi: https://doi.org/10.14740/jnr427w
Comparison of multi-beam pillbox antennas using leaky-wave and slotted waveguide radiating parts for automotive radars at millimeter-waves

This work deals with a comparison between multi-beam leaky-wave and slotted waveguide pillbox antennas. The antenna systems present the same pillbox architecture: feeding part, quasi-optical system and radiating part. Two different radiating parts are considered: a leaky-wave solution and an array of slotted waveguides. In particular, an array of slots etched on the uppermost metal layer of the pillbox structure and 23 waveguides with 8 radiating slots are adopted for the leaky-wave and slotted waveguide solution, respectively. The quasi-optical system and feeding part used in both antennas are the same. The quasi-optical system is made by a pin-made integrated parabola and several coupling slots, and is used to shape and focus the energy coming from the input part to the radiating part. Seven pin-made integrated horns are placed in the focal plane of the integrated parabola to radiate seven beams in the far field. The antenna performances in terms of efficiency, bandwidth and scanning capabilities are compared. Both the proposed antennas are low-cost, low profile, compact, efficient and very promising solutions for applications in the millimeter-wave range, especially for long range automotive radars.
A FIVE-YEAR PLAN FOR AUTOMATIC CHESS

Young animals play games in order to prepare themselves for the business of serious living, without getting hurt in the training period. Game-playing on computers serves a similar function. It can teach us something about the structure of thought processes and the theory of struggle and has the advantage over economic modelling that the rules and objectives are clear-cut. If the machine wins tournaments it must be a good player. The complexity and originality of a master chess player is perhaps greater than that of a professional economist. The chess player continually pits his wits against other players and the precision of the rules makes feasible a depth of thinking comparable to that in mathematics. No program has yet been written that plays chess of even good amateur standard. A really good chess program would be a breakthrough in work on machine intelligence, and would be a great encouragement to workers in other parts of this field and to those who sponsor such work. In criticism of the writing of a chess program, Macdonald (1950) quoted a remark to the effect that a machine for smoking tobacco could be built, but would serve no useful purpose. The irony is that smoking machines have since been built in order to help research on the medical effects of smoking. This does not prove that a chess program should be written, but suggests that the arguments against it might be shallow. Many branches of science, and of pure and applied mathematics, have started with a study of apparently frivolous things such as puzzles and games.