Miracle-dz/UniFAR-FTUs huggingface dataset:
The effect of radiofrequency radiation on DNA and lipid damage in female and male infant rabbits

Purpose: We aimed to design a prolonged radiofrequency (RF) radiation exposure and investigate in an animal model, possible bio-effects of RF radiation on the ongoing developmental stages of children from conception to childhood. Materials and methods: A total of 72 New Zealand female and male white rabbits aged one month were used. Females were exposed to RF radiation for 15 min/day during 7 days, whereas males were exposed to the same level of radiation for 15 min/day during 14 days. Thirty-six female and 36 male infant rabbits were randomly divided into four groups: Group I [Intrauterine (IU) exposure (−); Extrauterine (EU) exposure (−)]: Sham exposure which means rabbits were exposed to 1800 MHz Global System for Mobile Telecommunication (GSM)-like RF signals neither in the IU nor in the EU periods. Group II [IU exposure (−); EU exposure (+)]: Infant rabbits were exposed to 1800 MHz GSM-like RF signals when they reached one month of age. Group III [IU exposure (+); EU exposure (−)]: Infant rabbits were exposed to 1800 MHz GSM-like RF signals in the IU period (between 15th and 22nd days of the gestational period). Group IV [IU exposure (+); EU exposure (+)]: Infant rabbits were exposed to 1800 MHz GSM-like RF signals both in the IU period (between 15th and 22nd days of the gestational period) and in the EU period when they reached one month of age. Biochemical analysis for lipid peroxidation and DNA damage were carried out in the livers of all rabbits. Results: Lipid peroxidation levels in the liver tissues of female and male infant rabbits increased under RF radiation exposure. Liver 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels of female rabbits exposed to RF radiation were also found to increase when compared with the levels of non-exposed infants. However, there were no changes in liver 8-OHdG levels of male rabbits under RF exposure. Conclusion: Consequently, it can be concluded that GSM-like RF radiation may induce biochemical changes by increasing free radical attacks to structural biomolecules in the rabbit as an experimental animal model.
Metabotropic glutamate group II receptors activate a G protein‐coupled inwardly rectifying K+ current in neurones of the rat cerebellum

1 The effects of the group II metabotropic glutamate receptor (mGluR) agonists DCG‐IV and LY354740 were examined in neurones freshly dissociated from the rat cerebellum and olfactory bulb, using the whole‐cell configuration of the patch‐clamp technique. 2 Under experimental conditions in which K+ currents would be inward, rapid application of DCG‐IV and LY354740 to interneurones expressing the group II mGluRs induced an inward current in a subpopulation of interneurones of the cerebellum, the unipolar brush cells. 3 The currents induced by DCG‐IV and LY354740 had the major characteristics of a G protein‐coupled inwardly rectifying K+ channel (GIRK) current; namely, rapid activation and deactivation upon agonist application and removal, G protein dependence, strong inward rectification, Cs+ and Ba2+ sensitivity, and K+ selectivity. 4 In Golgi cells of the cerebellum and interneurones of the accessory olfactory bulb, which also express group II mGluRs, LY354740 did not induce GIRK activation but inhibited voltage‐gated Ca2+ channel currents. 5 These results demonstrate that, in unipolar brush cells, native group II mGluRs can functionally couple to activation of GIRKs. Thus, the absence of coupling in the majority of CNS neurones examined to date may be due to restricted cellular co‐localization or co‐expression of the appropriate proteins.
A World Without Words: The Social Construction of Children Born Deaf And Blind

A World Without Words1998 What feeds the inspiration of the designer? Observation. In Jasper Morrison's collection of pictures, the icons of design history meet up with the unassuming objects of everyday life. Every picture tells a story and creates a new one in juxtaposition with its neighbor -without words, in the language of form. Morrison responds to the arbitrariness of form with simplicity and complexity, poetry and humor in a repertoire of compelling designs. A World Without Words is a pocket-sized school of seeing that addresses designers and consumers who wish to explore the universe of goods.
How to achieve constitutive expression of a gene within an inducible operon: the example of the nagC gene of Escherichia coli

The nagC gene, encoding the NagC repressor/activator of the nag regulon, is part of the nagBACD operon. When the promoter-proximal nagB and nagA genes are induced 20- to 40-fold, the nagC gene is induced only two- to threefold. In addition to being transcribed as part of the polycistronic nagBACD mRNA, nagC is also expressed from two promoters located within the upstream nagA gene. These promoters are comparable in strength to the induced nagB promoter, resulting in a high basal level of the nagC mRNA. This means that when the nagBA genes are induced, there is a much smaller effect on the amount of nagC mRNA. The nagC gene is subject to low-level translation so that the amount of NagC protein is kept low despite the relatively high transcription levels.
Postmortem Biochemistry Analysis of Metabolic Imbalance

8 INTRODUCTION . 9 REVIEW OF THE LITERATURE . 11 1. Derangements in carbohydrate metabolism causing acidosis . 11 1.1 Diabetes and its acute complications . 11 1.2 Alcohol abuse and metabolic disturbances . 12 1.3 Formation of ketone bodies and ketoacidosis . 13 1.4 Lactic acidosis in diabetes and alcohol abuse . 15 1.5 D-lactate in diabetes . 15 2. Postmortem analysis of metabolic disturbances . 16 2.1 Evaluation of glycemic balance by analyzing PM samples . 16 2.2 Analysis of PM samples to reveal DKA and AKA . 18 2.3 PM analysis of C-reactive protein . 18 2.4 Lactate measurement and interpretation of results of PM samples . 19 AIMS OF THE STUDY . 20 MATERIALS AND METHODS . 21 1. Samples . 21 2. Autopsy data . 21 3. Statistical methods . 21 4. Glucose and lactate measurements . 21 5. Ketone body measurements . 22 6. Methods for analyzing glycated hemoglobin . 22 7. CRP measurements . 23
Inappropriate Psychiatric Admission of Elderly Patients with Unrecognized Delirium

Objectives: To explore factors that might contribute to misattribution of mental status changes to psychiatric illness when an elderly patient actually has a delirium (mental status changes due to a medical condition). Methods: Records of 900 elderly patients referred to a Veterans Affairs psychiatric inpatient unit and 413 to an inpatient psychiatric team at a public hospital from 2001 to 2007 were reviewed. Cases referred because of symptoms secondary to an unrecognized delirium underwent further analysis of preadmission assessments. Comparisons were made to elderly patients with delirium appropriately admitted to medical units. Results: Thirty (2.3%) of the patients referred to psychiatric units were found to have a physical disorder requiring medical intervention within twelve hours. Compared to 30 delirious patients admitted to medical units, those inappropriately referred to psychiatric units had significantly lower rates of adequate medical histories, physical examinations, cognitive assessments, and laboratory/radiological studies. Among patients with delirium referred to psychiatric units, 66.7% had a history of mental illness, versus 26.7% of comparable admissions to medical units (&khgr;2 (7) = 60.00, P < 0.001). Conclusions: Our findings suggest that elderly patients with delirium admitted to psychiatric units are less likely to undergo complete diagnostic assessments than delirious elderly patients admitted to medical units. Symptoms of delirium appear more likely to be incorrectly attributed to psychiatric illness in patients with a history of mental illness than in patients without such a history. Possible explanations for these findings and suggestions for addressing these issues are offered.
Simian virus 40 T antigen can transcriptionally activate and mediate viral DNA replication in cells which lack the retinoblastoma susceptibility gene product

Simian virus 40 T antigen is a multifunctional protein which has recently been shown to form a complex with the retinoblastoma susceptibility gene product (Rb protein) (J.A. DeCaprio, J.W. Ludlow, J. Figge, J.-Y. Shaw, C.-M. Huang, W.-H. Lee, E. Marsilio, E. Paucha, and D.M. Livingston, Cell 54:275-283, 1988; P. Whyte, K.J. Buchkovich, J.M. Horowitz, S.H. Friend, M. Raybuck, R.A. Weinberg, and E. Harlow, Nature (London) 334:124-129, 1988). This interaction may facilitate some of the functions of T antigen. The ability of simian virus 40 T antigen to mediate transcriptional activation and viral DNA replication was tested in human osteosarcoma cell lines U-2OS and Saos-2, which are Rb positive and Rb negative, respectively. Both functions of T antigen were efficient in both cell lines. Hence, these functions can occur in the absence of Rb protein.
Recognition of emotion using non-linear dynamics of speech

Recognition of human's emotion from speech has become one of the most challenging and attractive fields of research in speech processing area. The present study aimed to detect valence of emotions, using Non-Linear Dynamic features (NLDs). NLDs are extracted from the Discrete Cosine Transform (DCT) of descriptor contours computed from Phase Space Reconstruction (PSR) of speech. These features are used to estimate emotion primitives in 3D continuous emotion space on the VAM database using Support Vector Regression (SVR) under the Leave-One-Out (LOO) testing technique. Feature selection is performed using Sequential Forward Selection (SFS). Activation, valence and dominance of emotions are estimated by the best correlation of 85.06%, 53.39% and 84.68%, respectively.
KNOWLEDGE AND PRACTICE OF BREAST SELF- EXAMINATION (BSE) AMONG FEMALES IN A RURAL AREA OF SOUTH INDIA

Introduction: Breast cancer is the most common cancer among women worldwide and it can be detected at an early stage through breast self-examination (BSE) which increases chances of survival. The study was aimed to assess knowledge and practice of breast self examination among females in a rural area of South India. Materials and methods: This descriptive cross-sectional study was carried out among a total sample of 314 women in rural area of South India. Females were interviewed using interviewer administered questionnaires to obtain information on their socio demographic characteristics, knowledge and practice of breast self-examination. Data were entered using SPSS 13.01. Results: In the present study, 30.89% women were in the age group 31-40 yrs. Most of the women (71.34 %) were married. Most of the women (44.27%) had secondary education and 13.69% were illiterate. Only 30.89% of the women were aware of breast selfexamination. In the study only 22.61% of the females had ever checked their breast. The level of awareness of breast self examination was highest among those aged 51- 60 years. Awareness of breast self examination was found to be significantly associated with educational attainment. Conclusion: The level of knowledge and practice of breast selfexamination among female is unacceptably low. Efforts should be made to increase level of knowledge and practice of breast selfexamination through health education programmes.
Neural network handoff in shadow-Rayleigh fading

A handoff algorithm in a cellular system under shadow-Rayleigh fading propagation is presented. The algorithm applies the timing advance for mobile positioning. The inputs of the proposed radial-basis function network consist of the mobile direction obtained by the MUSIC method on an array antenna, the received signal strengths (RSSs) of the mobile from the serving cell and from nearby cells and traffic intensities. Consequently, we obtain a significantly improved performance in comparison to the hysteresis rule. The evaluations are done in measurements of (1) handoff rate, blocking rate, dropping rate versus the traffic intensities and mean arrival times and (2) the difference between the mobile signal strength and the required minimum strength value before the system drop the calls versus the number of handoffs.
Symptomatology of minor psychiatric morbidity: a crosscultural comparison

Synopsis The basic symptoms of minor psychiatric morbidity (MPM) reported elsewhere were also found in a community survey in Taiwan. However, differences in the patterns of and manifestations of the symptoms were evident. Contrary to most Western surveys, the prevalence of anxiety (24·7 %) was found to be higher than that of depression (8·3 %) in Taiwan. Possible explanations based on sociocultural characteristics of the Chinese family were proposed. The notion of somatization as a predominant symptom in Chinese neurotic patients advocated by some research workers was not supported in this study. As a result of findings in community cases, it is argued that the importance of somatization has been considerably overemphasized as a factor in the illness behaviour of neurotic cases in Chinese and other cultures, and it is therefore not a culturespecific disease phenomenon. It is also suggested that certain culture-specific neurotic syndromes reported in Chinese, such as shen-ching-shuai-jo (neurasthenia) and shen-k'uei (semen loss syndrome), are clinically equivalent to MPM. Implications of the present findings on crosscultural research and management of MPM were discussed.
Process-Induced Variations of 10-nm Node Bulk nFinFETs Considering Middle-of-Line Parasitics

Process-induced variations of 10-nm node n-type FinFETs considering middle-of-line parasitics were investigated in terms of dc/ac performances using fully calibrated TCAD simulations. Variations of positive fixed oxide charge density at shallow trench isolation interface and source/drain (S/D) height influenced off-state and on-state performance variations, respectively, but slightly on RC delay variations. Fin width variations induced off-state performance and RC delay variations critically due to the fluctuation of short channel effects. But, fin height variations affected them slightly due to the preserved gate-to-channel controllability and the buffered effects by varying drain currents and gate capacitances in the same direction. Gate length, spacer length, and S/D length variations influenced dc/ac performance variations severely; 2-nm-length changes were barely acceptable to satisfy 10% RC delay margin. Thus, the process-induced variability parameters, including fin width, gate length, spacer length, and S/D length, should be controlled tightly under a few nanometers to reduce dc/ac performance variations of the FinFETs.
Extra views on structure and dynamics of DNA loops on nucleosomes studied with molecular simulations

ABSTRACT It has been shown experimentally that the action of the RSC chromatin remodeler leads to the formation of an irregular, partially remodeled nucleosome, termed a remosome. The remosome contains an extra 30–40 base pairs of DNA compared to a canonical nucleosome. Large-scale molecular simulations have provided information on the probable structure of remosomes and have explained why they remain stable in the absence of RSC. Here we explain how these simulations were carried out and what the resulting remosome models imply in terms of the mechanism of action of RSC. We notably show that local kinks within DNA are key in explaining how extra DNA can be in added to nucleosomes without unduly disturbing DNA-histone binding.
Immunocytochemical Demonstration of Cytochrome c Oxidase as a Marker for Renal Oncocytes and Oncocytomas

Using an antibody raised against the mitochondrial enzyme cytochrome c oxidase (EC 1.9.3.1), it was possible to visualize microoncocytomas, oncocytic tubules and even single oncocytes in the renal cortex of rats treated with N-nitrosomorpholine, and to localize the lesions to the collecting duct of the nephron. In human specimens, the antibody also stained oncocytomas and oncocytic tubules in the surrounding macroscopically unaffected cortex. Thus, this antibody may be used for detection as well as for investigation of the development of oncocytic lesions in various species.
Efficient Shape Reconstruction of Microlens Using Optical Microscopy

The imaging properties of a microlens are highly related to its 3-D profile; therefore, it is of fundamental importance to measure its 3-D geometrical characteristics with high accuracy after industrial fabrication. However, common 3-D measurement tools are difficult to use for fast, noninvasive, and precise 3-D measurement of a microlens. Depth acquisition is a direct way to understand the 3-D properties of objects in computer vision, and shape from defocus (SFD) has been demonstrated to be effective for 3-D reconstruction. In this paper, a depth reconstruction method from blurring using optical microscopy and optical diffraction is proposed to reconstruct the global shape of a microlens. First, the relationship between the intensity distribution and the depth information is introduced. Second, a blurring imaging model with optical diffraction is formulated through curve fitting, accounting for relative blurring and heat diffusion, and a new SFD method with optical diffraction and defocused images is proposed. Finally, a polydimethylsiloxane (PDMS) microlens is used to validate the proposed SFD method, and the results show that its global shape can be reconstructed with high precision. The average estimation error is 77 nm, and the cost time is reduced by 92.5% compared with atomic force microscopy scanning.
Primary care patients’ attitudes to priority setting in Sweden

Objective. To analyse attitudes to priority setting among patients in Swedish primary healthcare. Design. A questionnaire was given to patients comprising statements on attitudes towards prioritizing, on the role of politicians and healthcare staff in prioritizing, and on patient satisfaction with the outcome of their contact with primary healthcare (PHC). Settings. Four healthcare centres in Sweden, chosen through purposive sampling. Participants. All the patients in contact with the health centres during a two-week period in 2004 (2517 questionnaires, 72% returned). Main outcomes. Patient attitudes to priority setting and satisfaction with the outcome of their contact. Results. More than 75% of the patients agreed with statements like “Public health services should always provide the best possible care, irrespective of cost”. Almost three-quarters of the patients wanted healthcare staff rather than politicians to make decisions on priority setting. Younger patients and males were more positive towards priority setting and they also had a more positive view of the role of politicians. Less than 10% of the patients experienced some kind of economic rationing but the majority of these patients were satisfied with their contact with primary care. Conclusions. Primary care patient opinions concerning priority setting are a challenge for both politicians and GPs. The fact that males and younger patients are less negative to prioritizing may pave the way for a future dialogue between politicians and the general public.
The L2 status factor and the declarative/procedural distinction

This chapter deals with the assumed qualitative difference between the learning of a chronologically true L2 and the subsequent learning of an L3, and the related issue of transfer from L2 into L3. In fact, some recent studies show that L2 can take on a stronger role than L1 as a transfer source in L3 learning. A possible explanation for this phenomenon is a strong impact of the L2 status factor , which we argue is due to the higher degree of cognitive similarity between L2 and L3 than between L1 and L3. Further theoretical support to the L2 status factor, as one of several possibly interacting factors that may determine the transfer source (L1, L2/s), is here provided by a neurolinguistic account, suggesting that the distinction between declarative and procedural memory can account for what might lie behind it.
A Faster Method Aiming Iris Extraction

In this paper, we present a technique for iris segmentation. The method finds the pupil in the first step. Next, it segments the iris using the pupil location. The proposed approach is based on the mathematical morphology operators of opening and closing, as well as histogram expansion and thresholding. The CASIA Iris Database from the Institute of Automation of the Chinese Academy of Sciences has been used for the tests. Several tests were performed with 200 different images, showing the efficiency of the proposed
No evidence for linkage between an insulin‐dependent diabetes mellitus‐susceptibility locus and immunoglobulin loci KM or GM

We studied 52 families having more than one member affected with insulin‐dependent diabetes mellitus (IDDM) for linkage of an IDDM‐susceptibility locus to the immunoglobulin loci KM and GM. Linkage was analyzed by the LOD score method using single‐locus recessive and dominant models of IDDM inheritance, with penetrances of the disease‐susceptible genotypes being dependent on age and reaching a maximum of 20% by age 40. We found no evidence for linkage of IDDM to KM or GM. Close linkage (recombination fraction <5%) was rejected for KM under the recessive model and for GM under both models. These results suggest either that there are no IDDM‐susceptibility loci closely linked to KM or GM or that use of a single‐locus model of IDDM (which ignores the effects of the susceptibility locus in the HLA region) is inadequate for their detection.
Proteomics-based identification of VDAC1 as a tumor promoter in cervical carcinoma

We used oxidative isotope-coded affinity tags (OxICAT) to investigate the global redox status of proteins in human papillomavirus (HPV)-related cervical cancer cells, in order to identify a potential target for gene therapy. Voltage-dependent anion channel 1 (VDAC1) was found to be highly oxidized in HPV-positive cervical cancer cells. VDAC1 expression correlated significantly with the invasion of cervical cancer, the grade of cervical intraepithelial neoplasia (CIN) and the expression of HPV16 E7 in CIN. Knockdown of VDAC1 in cell lines increased the rate of apoptosis, while overexpression of the VDAC1 (respectively) partly reversed the effect. Thus, VDAC1 may promote the malignant progression of HPV-related disease, and treatments designed to suppress VDAC1 could prevent the progression of HPV-induced cervical disease.
Let's drink and be merry: the framing of alcohol in the prime-time American youth series The OC.

OBJECTIVE This study analyzed the framing of alcohol consumption in the American adolescent drama series The OC. METHOD All 51 episodes of Seasons 1 and 2 of The OC were coded for visual and verbal references to beverage use on the level of the scene (n = 1,895) and on the level of the drinking act (n = 1,033). Subsequently, all episodes were analyzed qualitatively through an inductive frame analysis. RESULTS Although the public's perception of The OC is that alcohol was overrepresented in this series, the quantitative results show the opposite. The focus was on active consumption and solitary drinking of alcohol, but in absolute terms there were more nonalcoholic drinking acts. The OC represents a trend break, compared with earlier analyses of alcohol consumption in television fiction: More than half of all alcoholic drinking acts involved women, and almost one third involved adolescents. The qualitative frame analysis revealed two commonly used frames (alcohol consumption as an "obligatory outlet" and alcohol consumption as "escapism") and two less frequently applied frames ("celebrate without the sauce" and alcohol addiction as "sickness"). CONCLUSIONS The findings suggest that the concept of framing might contribute to this field of study by analyzing the underlying cultural frames that suggest how the receiver may interpret the consumption of alcohol in fictional television programs.