Miracle-dz/UniFAR-FTUs huggingface dataset:
Nanometric Hydroxyapatite Particles as Active Ingredient for Bioinks: A Review

: Additive manufacturing (AM), frequently cited as three-dimensional (3D) printing, is a relatively new manufacturing technique for biofabrication, also called 3D manufacture with biomaterials and cells. Recent advances in this ﬁeld will facilitate further improvement of personalized healthcare solutions. In this regard, tailoring several healthcare products such as implants, pros-thetics, and in vitro models, would have been extraordinarily arduous beyond these technologies. Three-dimensional-printed structures with a multiscale porosity are very interesting manufacturing processes in order to boost the capability of composite scaffolds to generate bone tissue. The use of biomimetic hydroxyapatite as the main active ingredient for bioinks is a helpful approach to obtain these advanced materials. Thus, 3D-printed biomimetic composite designs may produce supplementary biological and physical beneﬁts. Three-dimensional bioprinting may turn to be a bright solution for regeneration of bone tissue as it enables a proper spatio-temporal organization of cells in scaffolds. Different types of bioprinting technologies and essential parameters which rule the applicability of bioinks are discussed in this review. Special focus is made on hydroxyapatite as an active ingredient for bioinks design. The goal of such bioinks is to reduce the constraints of commonly applied treatments by enhancing osteoinduction and osteoconduction, which seems to be exceptionally promising for bone regeneration.
Bacillus Thuringiensis Var. Aizawai HD-137 as a Potential Agent for Biological Control

: Four strains of Bacillus thuringiensis were screened for their chitinolytic activity on colloidal chitin. B. thuringiensis var. aizawai HD-137 with the GenBank accession number HM173355 showed the highest chitinase activity, which was recorded after 2 days of incubation. The optimum condition for high chitinase production was Nutrient Yeast extract, Salt Medium, NYSM, with 0.2% colloidal chitin, two days of incubation, pH 6 and 30 ° C. The novel strain B. thuringiensis var. aizawai HD-137 is also considered as a powerful phytopathogenic control agent in which it showed inhibition of the mycelial growth of some phytopathogenic fungi, Alternaria solani , Rhizopus B1 and B2, Fusarium solani and Aspergillus flavus . The clear zones of mycelial inhibition ranged from 12 to 19mm. The partial nucleotides sequence of chitinase gene from B. thuringiensis var. aizawai HD-137 showed similarities to the chitinase producing bacteria in the GenBank, and it was more related to B. thuringiensis (AB699714, GQ921840 and GQ921842) and B. ehimensis chi60 (AB110081). It is obvious that the B. thuringiensis var. aizawai HD-137 is considered as a significant biocontrol agent against phytopathogenic fungi.
ONTOLOGY BASED DATA AND INFORMATION INTEGRATION IN BIOMEDICAL DOMAIN

: One of the main problems of biomedical informatics in the effort to increase its contribution in knowledge retrieval and decision making is the integration of ever-increasing amounts of information and data from multiple heterogeneous sources and domains - clinical, medical, biological etc. The paper proposes an ontology based approach for integration of biomedical data and information using the Linked Open Data vocabularies and a D2RQ-mapped database. A simple example of semantic integration of heterogeneous biomedical and health data sources is given
Evolution of Electron Properties After Nanosecond Repetitively Pulsed Discharges in Air Measured by Thomson Scattering

Murray, Chase S. M.S. Department of Physics, Wright State University, 2020. Evolution of Electron Properties After Nanosecond Repetitively Pulsed Discharges in Air Measured by Thomson Scattering. This work was an investigation of nanosecond repetitively pulsed discharges in air by measuring the evolution of electron density and electron temperature between pulses using Thomson scattering of laser light. Bursts of repetitive pulses within several microseconds after the initial pulse were found to exhibit a coupling effect and create an even higher electron density than the initial pulse. The wide range of temperatures and densities of the electrons existing between pulses allow an opportunity to explore both the collective and non-collective regimes of Thomson scattering. By measuring electron density and temperature at a variety of times, an accurate description of the coupling between discharges can been formulated which provides insight into the behavior and potential applications of nanosecond repetitive pulse discharges.
CEOR_A_244329 285..297

Kavita Gandhi Wenhui Wei 2 Ahong Huang Li Wang Ravi Iyer Nathaniel P Katz 1Teva Pharmaceutical Industries, Frazer, PA, USA; 2Regeneron Pharmaceuticals, Tarrytown, NY, USA; 3STATinMED Research, Dallas, TX, USA; 4Analgesic Solutions, Wayland, MA, USA; 5Tufts University School of Medicine, Boston, MA, USA Background: Although opioids may be used in the management of pain in patients with osteoarthritis (OA), there is a dearth of real-world data characterizing opioid regimen failure in these patients. Objective: Using claims data, this study explored measures that may be potentially indicative of opioid treatment failure and the association of such potential failure with health care resource utilization (HRU) and costs. Patients and Methods: Using a national employer-sponsored insurance claims database covering the years 2011–2016, this retrospective longitudinal study identified adults with hip/ knee osteoarthritis who filled ≥1 opioid prescription (index event) and had continuous health plan enrollment 6 months preand ≥12 months post-index. Index opioid regimen intensity was defined in the 3-month post-index period by frequency, average daily dose, and duration of action. Possible index opioid regimen failure was defined as an increase in opioid regimen intensity, addition of a non-opioid pain medication, joint surgery, or opioid-abuse-related events. One-year follow-up HRU and costs were compared between those with possible treatment failure and those without. Results: Among 271,512 OA patients (61.5% knee; 11.1% hip; 27.4% both), 34.9% met the definition of possible index opioid regimen failure within a year: increased regimen intensity (16.1%), joint surgery (14.0%), addition of non-opioid pain medication (11.4%), and opioidabuse-related events (1.9%). Rates of possible failure generally increased with higher index regimen intensity. Compared with those who did not fail, those who potentially failed their index treatment regimen had significantly higher HRU (P<0.001), and all-cause ($36,699 vs $15,114) and osteoarthritis-related costs ($17,298 vs $1,967) (both P<0.0001). Conclusion: Among OA patients treated with opioids, approximately one-third may fail their index opioid regimen within a year and incur significantly higher HRU and costs than those without. Further research is needed to validate these findings with clinical outcomes.
PRELIMINARY ASSESSMENT OF THE EFFECTS HYDROMETHANOLIC EXTRACT OF DIOSCOREA BULBIFERA ON HAEMATOLOGICAL PARAMETERS AND SERUM ELECTROLYTES OF WISTAR RATS.

The ethnomedicinal uses of Dioscorea bulbifera has been widely reported in different parts of the world. This study evaluated the effects of hydromethanolic extract of Dioscorea bulbifera on hematological parameters and serum electrolytes using wistar rats. Forty eight (48) adult albino wistar rats were used for the study. They were divided into four groups comprising of twelve (12) rats per group. The control group received distilled water while the experimental groups received hydromethanolic extracts of Dioscorea bulbifera extract orally at 20mg/kg, 50mg/kg and 100mg/kg. Hematological parameters and serum electrolytes were analyzed using standard methods. Results for hematological analysis show a significantly increased mean value for packed cell volume, red blood cell counts, haemoglobin concentration, neutrophil and lymphocytes counts in experimental group compared to control(p<0.05). There was a significant decrease in mean values for MCH and MCV in experimental group compared to control. Results from serum electrolytes indicated a higher mean value for serum sodium ion concentration and urea in experimental group compared to control (p<0.05) with a significantly reduced creatinine in experimental group compared to control (p<0.05). The present study has shown that hydromethanolic extract of Dioscorea bulbifera improved haematological parameters and hence justifies its use as a folk remedy in blood related diseases.
Investigating the relationship between managerialist employment relations and employee turnover intention: the case of Nigeria

Purpose – This article investigates the relationship between managerialist employment relations and employee turnover intention in Nigeria. The study context is public hospitals in Nigeria, which have a history of problematic human resource management (HRM) practice, a non-participatory workplace culture, managerialist employment relations, and a high employee turnover intention. Design/methodology/approach – Based on a qualitative, interpretive approach, this paper investigates the process by which Nigerian employment relations practices trigger the employee turnover intention of doctors using 33 semi-structured interviews with key stakeholders in public hospitals. Findings – This study found that Nigeria’s managerialist employment relations triggers the employee turnover intention of medical doctors. Additionally, it was found that although managerialist employment relations lead to turnover intention, Nigeria’s unique, non-participatory, and authoritarian employment relations system exacerbates this situation, forcing doctors to consider leaving their employment. Implications/limitation – Studies on the interface between managerialism and employment relations are still under-researched and underdeveloped. This paper also throws more light on issues associated with managerialist employment relations and human resources practice including stress, burnout, and dissatisfaction. Their relationship with doctors’ turnover intention has significant implications for employment policies, engagement processes, and human resources management in general. The possibility of generalising the findings of this study is constrained by the limited sample size and its qualitative orientation. Originality/value – This paper contributes to the dearth of studies emphasising employer-employee relationship quality as a predictor of employee turnover intention and a mediator between managerialist organisational system and turnover intention. The study further contributes to the discourse of employment relations and its concomitant turnover intention from developing countries’ perspective within the medical sector.
From Conventional to Technology-Assisted Alternative Assessment for Effective and Efficient Measurement: A Review of the Recent Trends in Comparability Studies

: There is no doubt that using computers in language testing as well as in language learning has some advantages and disadvantages. Despite the widespread use of computer-based testing, relatively few studies have been conducted on the equivalency of two test modes especially in academic contexts. However, some institutes and educational settings are going towards using computerized test due to its advantages without doing any comparability investigation beforehand. Perhaps because they mostly believe that if the items are identical, the testing mode is irrelevant. As the use of computerized test types is rapidly expanding, we need appropriate use of technology as a facet of language learning and testing. Regarding this accelerating development in computerized tests in language testing, further investigations are needed to ensure the validity and fairness of this administration mode in comparison with traditional one. This study provides a brief discussion on the importance of substituting CBT for PPT and necessity of doing comparability study before this transition. It presents the significance of the study followed by an illustration of the background of the comparability studies of CBT
Exendin-4 suppresses Src activation and reactive oxygen species production in diabetic GK rat islets in an Epac-dependent manner

Reactive oxygen species (ROS) is one of most important factors in impaired metabolism-secretion coupling in pancreatic β -cells. We recently reported that elevated ROS production and impaired ATP production at high glucose in diabetic Goto-Kakizaki (GK) rat islets are effectively ameliorated by Src inhibition, suggesting that Src activity is upregulated. In the present study, we investigated whether the glucagons-like peptide-1 signal regulates Src activity and ameliorates endogenous ROS production and ATP production in GK islets using exendin-4. Design and Methods- Isolated islets from GK and control Wistar rats were used for immunoblotting analyses and measurements of ROS production and ATP content. Src activity was examined by immunoprecipitation of islet lysates followed by immunoblotting. ROS production was measured with fluorescent probe using dispersed islet cells.
Hirarchical Bayesian Spatio-Temporal Interpolation including Covariates

The space-time interpolation of precipitation has significant contribution to river control,reservoir operations, forestry interest and flash flood watches etc. The changes in environmental covariates and spatial covariates make space-time estimation of precipitation a challenging task. In our earlier paper [1], we used transformed hirarchical Bayesian sapce-time interpolation method for predicting the amount of precipiation. In present paper, we modified the [2] method to include covarites which varaies with respect to space-time. The proposed method is applied to estimating space-time monthly precipitation in the monsoon periods during 1974 − 2000. The 27-years monthly average data of precipitation, temperature, humidity and wind speed are obtained from 51 monitoring stations in Pakistan. The average monthly precipitation is used response variable and temperature, humidity and wind speed are used as time varying covariates. Moreovere the spatial covarites elevation, latitude and longitude of same monitoring stations are also included. The cross-validation method is used to compare the results of transformed hierarchical Bayesian spatio-temporal interpolation with and without including environmental and spatial covariates. The software of [3] is modified to incorprate enviornmental covariates and spatil covarites. It is observed that the transformed hierarchical Bayesian method including covarites provides more accuracy than the transformed hierarchical Bayesian method without including covarites. Moreover, the five potential monitoring cites are selected based on maximum entropy sampaling design approach.
Performance Evaluation of High-Resolution Time-of-Flight Cameras

A Time-of-Flight (ToF) camera is a 3D imaging device to perceive the range information between the ToF sensor and the scene for each camera’s imaging plane pixel. It has been about 20 years since the first ToF prototype was invented based on Photonic Mixer Device (PMD) technology. With the breakthrough of ToF sensor arrays with resolutions matching the Video Graphics Array (VGA 640×480 px) and beyond in recent years, more and more high-resolution ToF cameras are pouring into the market. In this Thesis, five state-ofthe-art high-resolution ToF cameras, Azure Kinect, Helios2, L515, S100D, and AD-96TOF1-EBZ, are compared via a series of experiments in terms of several key parameters, such as warm-up time, precision, lateral resolution, range resolution, and flying pixels. Some notable results are as follows: At a distance of 1m from the white panel, the distance measurement of S100D is stable with a fluctuation within 1 mm after being powered up. Azure Kinect, Helios2, and L515 can achieve precision within 2 mm in the measuring range of 0.5 to 3 m. For the point cloud of the white panel generated by L515 at a distance of 1.5m, only a small amount of flying pixel noise exists at the edge.
ANALYSIS OF THE FACTORS AFFECTING ILLNESS PERCEPTION WITH HEART FAILURE IN LOCAL POPULATION OF PUNJAB

: Introduction: Heart Failure (HF) is widespread in aging populations across the world. In addition, prevalence rates of depressive disorders in various cardiological conditions are significantly higher than in healthy general population. Objectives: The basic aim of the study was to assess the factors affecting illness perception with heart failure in local population of Punjab. Material and methods: This cross sectional study was conducted in health department Punjab during 2019. The data was collected from 100 patients of heart failure. Patients were excluded if their HF originated from valvular heart disease or pregnancy, or if they had had a myocardial infarction or stroke within the previous 3 months, because these might affect HF progress and patient outcomes, including HRQOL and hospitalizations. Results: The data was collected from 100 patients of both genders. The mean age was 67 years (69.8 years for women and 66.6 years for men) and ranged from 34 to 70 years. In 42.7%, other diseases coexisted. Only one person had not been informed at all about the health problem. Conclusion: It is concluded that illness perceptions hold a principal role in elucidating depressive symptomatology and anxiety in HF, relative to other known covariates.
Intrinsic motivation within and across time. The case of extrinsically oriented

Self-determination theory assumes that healthy motivation needs to be intrinsic in nature and that the basic psychological needs competence, autonomy and relatedness are prerequisites for intrinsically motivated behaviour. Intrinsically motivated students in turn show more persistence and understanding of classroom material. However, in (pre-vocational) secondary education, many students have an extrinsic orientation and we cannot assume that the principles advocated by self-determination theory are automatically applicable in this context. We tested a model relating basic psychological needs via intrinsic motivation to persistence and performance at two waves using data from 476 students (aged 11-17) attending pre-vocational secondary education. Structural equation analysis showed that a partial mediation model fitted the data best at both waves. Interestingly, the strength of the effects varied across waves, such that relatedness and autonomy became negative predictors of intrinsic motivation for a familiar task. The practical and theoretical implications of these findings are discussed.
Subsurface Imaging with Ocean‐Bottom Distributed Acoustic Sensing and Water Phases Reverberations

Supporting Information for ”Subsurface Imaging with Ocean-Bottom Distributed Acoustic Sensing and Water Phases Reverberations” Zack J. Spica, Jorge C. Castellanos, Löıc Viens, Kiwamu Nishida, Takeshi Akuhara, Masanao Shinohara, Tomoaki Yamada 1Department of Earth and Environmental Sciences, University of Michigan, Ann Arbor, Michigan, USA 2Seismological Laboratory, Department of Earth and Planetary Sciences, California Institute of Technology, Pasadena, California,
Design explorations for more efficient data filtering interaction principles in VR for map based information visualizations

When using web interfaces to filter data on map-based visualizations, filtering interfaces tend to acquire space that otherwise could be used by the visualization. This study examines how to make use of virtual reality’s strengths to design more efficient data filtering interaction principles for map-based visualizations. To do this, a virtual reality application was developed and tested on 19 subjects performing 9 predetermined tasks. Qualitative data was gathered through semi-structured interviews and observations along with quantitative data derived from logging user interactions. These results were compared to a control study with subjects using an already existing web based filtering interface. Results indicate that using some of virtual reality’s strengths such as 3D space, two-hand interaction and body movement when designing filtering interfaces can increase efficiency of data filtering interactions on map-based visualizations. The main advantages of interfaces like these seems to be that the strengths of virtual reality provides room for efficient solutions to observe and filter data simultaneously.
Gigantic Coaxial Line for Experimental Studies of the Interaction of Nanosecond Electromagnetic Pulses with an Ionized Gas Medium

: A large-scale coaxial line ﬁlled with the plasma of RF discharge has been developed for laboratory modeling of the effects of the interaction of ultrashort electromagnetic pulses (EMPs) with the atmosphere and the ionosphere in the KROT facility. The oversized coaxial line ensures pulse transmission through an ionized medium in the TEM mode, which corresponds to the polarization of the transverse electromagnetic wave in free space, and in uniform isotropic plasma. The coaxial line has a length of 10 m and a diameter of 140 cm. The processes of propagation of the nanosecond and subnanosecond pulses in this line, in vacuum and with plasma, have been simulated numerically.
Short Title: Tomato cell wall mutants and ripening Characterisation of CRISPR mutants targeting genes modulating pectin degradation in ripening tomato

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Attaining Competitive Advantagethrough Market Orientation of Public Higher Education Institutions:Mediating Effect of Quality Assurance

The literature review thus far has indicated numerous studies have examined the relationship between market orientation (MO)and competitive advantage (CA)leading to greater organizational performance. A substantial number of studies on strategic management orientations have shown significant relationships between MO and organizational performance but direct contribution of CA is still lacking in consensus. Thispaper reviews the literature on the influence of market orientation (MO) towards competitive advantage and the mediating effect of quality assurance in public higher education institutions (PHEIs). The reviews specify that market orientation as the marketing strategic platformis likely to achieve superior value in gaining and sustaining competitive advantage however, within the context of PHEIs such relationships are still inconclusive. Quality assurance (QA) is postulated to have amediating effect in the suggested framework of market orientation and competitive advantage. As QA is becoming a critical factor in the knowledge-based society, thisvariable needs to be explored further in the context of higher education.Thus, the aim of this paper is to accumulate existing literature in the investigationof the relationship between MO and CA as well as the effect of QA towards the performance of PHEIsbased on non-financial dimensions.