Miracle-dz/UniFAR-FTUs huggingface dataset:
Predicting Factors of Angiographic Aneurysm Occlusion after Treatment with the Woven EndoBridge Device: A Single-Center Experience with Midterm Follow-Up

BACKGROUND AND PURPOSE: Flow disruption with the Woven EndoBridge is increasingly used for the treatment of intracranial aneurysms. We examined factors leading to aneurysm occlusion and Woven EndoBridge shape change during a midterm follow-up. MATERIALS AND METHODS: Patients with a minimum 12-month angiographic follow-up were included. Through a univariate and multivariate analysis, independent predictors of adequate occlusion (Raymond-Roy 1/Raymond-Roy 2) and Woven EndoBridge shape change (decrease of the height of the device) were assessed. RESULTS: Eighty-six patients/aneurysms were included. The aneurysm mean size was 5.5 mm (range, 3–11.5 mm). The most common locations were the MCA (43/86 = 50%), basilar tip (13/86 = 15.1%), and anterior communicating artery (12/86 = 14%). Twenty-one patients (21/86 = 24%) had acute SAH. Immediate and long-term Raymond-Roy 1/Raymond-Roy 2 occlusion rates were 49% (42/86) and 80% (68/86), respectively. Woven EndoBridge shape change was detected among 22% (19/86) of cases. At binary logistic regression, wide ostium (≥4 mm) (OR = 0.2; 95% CI, 0.01–1; P = .04) and regular aneurysm morphology (OR = 5.9; 95% CI, 1.4–24; P = .01) were independent factors of incomplete and adequate aneurysm occlusion, respectively. In addition, irregular morphology (OR = 5.4; 95%CI, 1.4–19; P = .01) and a wide ostium (OR = 9.8; 95% CI, 1.6–60; P = .03) significantly increased the probability of the Woven EndoBridge shape change. Decrease of the Woven EndoBridge height was more common among incompletely occluded aneurysms (6/12 = 50% versus 13/74 = 17.5%), but it was not an independent prognosticator of occlusion at the multivariate model. CONCLUSIONS: The likelihood of good occlusion was 5 times lower in the presence of a wide ostium, whereas aneurysms with regular morphology were 6 times more likely to be occluded. Woven EndoBridge shape modification was strongly influenced by the aneurysm shape and ostium size, and it was not independently associated with the angiographic occlusion.
The role of protein aggregation in Huntington's disease.

Huntington’s disease (HD) is a hereditary progressive neurodegenerative disorder characterised by chorea, general motor impairment, psychiatric disturbances and dementia, leading to death within 10 to 20 years of onset. It is caused by a (CAG) n trinucleotide repeat expansion in the gene IT15 that is translated into a prolonged polyglutamine tract in the protein huntingtin. This mutation leads to the self-association of huntingtin to form aggregates in the brains of affected people. Work in Professor Nicotera’s group at the MRC Toxicology Unit identified expression changes in Rab11, a protein involved in endosomal recycling, in a cell culture model of HD. The aim of this thesis was to investigate whether endosomal recycling is affected in this model. Monitoring the trafficking of labelled transferrin by Western blotting and live-cell imaging showed rapid uptake of transferrin into all cells, but a significantly reduced rate of clearance in cells containing huntingtin aggregates, which was associated with the accumulation of transferrin in the endosomal recycling compartment (ERC). This finding demonstrates an aggregate-specific lesion in the exit of cargo from the ERC in the absence of cell death. As endosomal recycling is essential for correct neuronal function, this process provides a mechanism whereby protein inclusions may contribute to the cognitive and motor deficits seen in HD. A second project focused on purification of aggregates to determine if they could sequester material important for cellular function. Many attempts to purify the aggregates in their intact globular form revealed their highly unspecific affinity towards other proteins, which renders purification methods very susceptible to artefacts. The large globular aggregates could, however, be dispersed by SDS-treatment into fibrils of approximately 10 nm diameter, which were subsequently purified and visualised by electron microscopy.
Seizure detection based on heart rate variability using a wearable electrocardiography device

To assess the feasibility and accuracy of seizure detection based on heart rate variability (HRV) using a wearable electrocardiography (ECG) device. Noninvasive devices for detection of convulsive seizures (generalized tonic‐clonic and focal to bilateral tonic‐clonic seizures) have been validated in phase 2 and 3 studies. However, detection of nonconvulsive seizures still needs further research, since currently available methods have either low sensitivity or an extremely high false alarm rate (FAR).
Skilled Movements in Mice Require Inhibition of Corticospinal Axon Collateral Formation in the Spinal Cord by Semaphorin Signaling

Corticospinal (CS) neurons in layer V of the sensorimotor cortex are essential for voluntary motor control. Those neurons project axons to specific segments along the rostro-caudal axis of the spinal cord, and reach their spinal targets by sending collateral branches interstitially along axon bundles. Currently, little is known how CS axon collaterals are formed in the proper spinal cord regions. Here, we show that the semaphorin3A (Sema3A)–neuropilin-1 (Npn-1) signaling pathway is an essential negative regulator of CS axon collateral formation in the spinal cord from mice of either sex. Sema3A is expressed in the ventral spinal cord, whereas CS neurons express Npn-1, suggesting that Sema3A might prevent CS axons from entering the ventral spinal cord. Indeed, the ectopic expression of Sema3A in the spinal cord in vivo inhibits CS axon collateral formation, whereas Sema3A or Npn-1 mutant mice have ectopic CS axon collateral formation within the ventral spinal cord compared with littermate controls. Finally, Npn-1 mutant mice exhibit impaired skilled movements, likely because of aberrantly formed CS connections in the ventral spinal cord. These genetic findings reveal that Sema3A–Npn-1 signaling-mediated inhibition of CS axon collateral formation is critical for proper CS circuit formation and the ability to perform skilled motor behaviors. SIGNIFICANCE STATEMENT CS neurons project axons to the spinal cord to control skilled movements in mammals. Previous studies revealed some of the molecular mechanisms underlying different phases of CS circuit development such as initial axon guidance in the brain, and midline crossing in the brainstem and spinal cord. However, the molecular mechanisms underlying CS axon collateral formation in the spinal gray matter has remained obscure. In this study, using in vivo gain-of- and loss-of-function experiments, we show that Sema3A–Npn-1 signaling functions to inhibit CS axon collateral formation in the ventral spinal cord, allowing for the development of proper skilled movements in mice.
Strong Purifying Selection Is Associated with Genome Streamlining in Epipelagic Marinimicrobia

Abstract Marine microorganisms inhabiting nutrient-depleted waters play critical roles in global biogeochemical cycles due to their abundance and broad distribution. Many of these microbes share similar genomic features including small genome size, low % G + C content, short intergenic regions, and low nitrogen content in encoded amino acid residue side chains (N-ARSC), but the evolutionary drivers of these characteristics are unclear. Here, we compared the strength of purifying selection across the Marinimicrobia, a candidate phylum which encompasses a broad range of phylogenetic groups with disparate genomic features, by estimating the ratio of nonsynonymous and synonymous substitutions (dN/dS) in conserved marker genes. Our analysis reveals that epipelagic Marinimicrobia that exhibit features consistent with genome streamlining have significantly lower dN/dS values when compared with their mesopelagic counterparts. We also found a significant positive correlation between median dN/dS values and % G + C content, N-ARSC, and intergenic region length. We did not identify a significant correlation between dN/dS ratios and estimated genome size, suggesting the strength of selection is not a primary factor shaping genome size in this group. Our findings are generally consistent with genome streamlining theory, which postulates that many genomic features of abundant epipelagic bacteria are the result of adaptation to oligotrophic nutrient conditions. Our results are also in agreement with previous findings that genome streamlining is common in epipelagic waters, suggesting that microbes inhabiting this region of the ocean have been shaped by strong selection together with prevalent nutritional constraints characteristic of this environment.
Guided Imagery: Reducing Anxiety, Depression, and Selected Side Effects Associated With Chemotherapy.

BACKGROUND Cancer treatment can be a great source of anxiety and depression for patients. Patients who experience anxiety and depression may be treated with a variety of nonpharmacologic treatments, such as guided imagery. OBJECTIVES The purpose of this article is to determine the effect of guided imagery on patients' anxiety, depression, and other selected side effects prompted by chemotherapy. METHODS This pre- and postintervention assessment randomly selected patients with various types of cancer who were undergoing chemotherapy to listen to a guided imagery audio file for 20 minutes per day for one week. Data collection included a demographic questionnaire, the Hospital Anxiety and Depression Scale, and the Symptom Distress Scale. FINDINGS A significant decrease in anxiety and depression was noted in the intervention group compared to the control group. No reduction in the mean score for anxiety and depression was observed postintervention for the control group. In addition, patients in the intervention group showed improvement in all side effect categories. Patients in the intervention group reported the greatest rate of improvement in the items of pain, insomnia, appetite, and nausea.
Identification of the Coding-Complete Genome of Cycas Necrotic Stunt Virus in Transcriptomic Data Sets of Alfalfa (Medicago sativa)

We present evidence here that alfalfa (Medicago sativa L.) can be a natural host species for a new strain of Cycas necrotic stunt virus (CNSV), for which the name CNSV-A (alfalfa) is proposed. Prior to this report, the virus has not been identified in alfalfa. ABSTRACT We present evidence here that alfalfa (Medicago sativa L.) can be a natural host species for a new strain of Cycas necrotic stunt virus (CNSV), for which the name CNSV-A (alfalfa) is proposed. Prior to this report, the virus has not been identified in alfalfa.
Complete Genome Sequences of Four Salmonella enterica Strains Associated with Pistachios Assembled Using a Combination of Short- and Long-Read Sequencing

Here, we report the genomes of two Salmonella enterica subsp. enterica serovar Montevideo strains (CFSAN005645 and FCC0123) and two Salmonella enterica subsp. enterica serovar Senftenberg strains (FSW0104 and CFSAN087304) isolated from pistachios. The genomes were closed using a hybrid assembly method using short- and long-read sequencing technology. ABSTRACT Here, we report the genomes of two Salmonella enterica subsp. enterica serovar Montevideo strains (CFSAN005645 and FCC0123) and two Salmonella enterica subsp. enterica serovar Senftenberg strains (FSW0104 and CFSAN087304) isolated from pistachios. The genomes were closed using a hybrid assembly method using short- and long-read sequencing technology.
HIF-transcribed p53 chaperones HIF-1α

Abstract Chronic hypoxia is associated with a variety of physiological conditions such as rheumatoid arthritis, ischemia/reperfusion injury, stroke, diabetic vasculopathy, epilepsy and cancer. At the molecular level, hypoxia manifests its effects via activation of HIF-dependent transcription. On the other hand, an important transcription factor p53, which controls a myriad of biological functions, is rendered transcriptionally inactive under hypoxic conditions. p53 and HIF-1α are known to share a mysterious relationship and play an ambiguous role in the regulation of hypoxia-induced cellular changes. Here we demonstrate a novel pathway where HIF-1α transcriptionally upregulates both WT and MT p53 by binding to five response elements in p53 promoter. In hypoxic cells, this HIF-1α-induced p53 is transcriptionally inefficient but is abundantly available for protein-protein interactions. Further, both WT and MT p53 proteins bind and chaperone HIF-1α to stabilize its binding at its downstream DNA response elements. This p53-induced chaperoning of HIF-1α increases synthesis of HIF-regulated genes and thus the efficiency of hypoxia-induced molecular changes. This basic biology finding has important implications not only in the design of anti-cancer strategies but also for other physiological conditions where hypoxia results in disease manifestation.
Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen.

BACKGROUND Although diabetic kidney disease demonstrates both familial clustering and single nucleotide polymorphism heritability, the specific genetic factors influencing risk remain largely unknown. METHODS To identify genetic variants predisposing to diabetic kidney disease, we performed genome-wide association study (GWAS) analyses. Through collaboration with the Diabetes Nephropathy Collaborative Research Initiative, we assembled a large collection of type 1 diabetes cohorts with harmonized diabetic kidney disease phenotypes. We used a spectrum of ten diabetic kidney disease definitions based on albuminuria and renal function. RESULTS Our GWAS meta-analysis included association results for up to 19,406 individuals of European descent with type 1 diabetes. We identified 16 genome-wide significant risk loci. The variant with the strongest association (rs55703767) is a common missense mutation in the collagen type IV alpha 3 chain (COL4A3) gene, which encodes a major structural component of the glomerular basement membrane (GBM). Mutations in COL4A3 are implicated in heritable nephropathies, including the progressive inherited nephropathy Alport syndrome. The rs55703767 minor allele (Asp326Tyr) is protective against several definitions of diabetic kidney disease, including albuminuria and ESKD, and demonstrated a significant association with GBM width; protective allele carriers had thinner GBM before any signs of kidney disease, and its effect was dependent on glycemia. Three other loci are in or near genes with known or suggestive involvement in this condition (BMP7) or renal biology (COLEC11 and DDR1). CONCLUSIONS The 16 diabetic kidney disease-associated loci may provide novel insights into the pathogenesis of this condition and help identify potential biologic targets for prevention and treatment.
Behavioral / Cognitive Neural Tuning to Numerosity Relates to Perceptual Tuning in 3 – 6-Year-Old Children

Neural representations of approximate numerical value, or numerosity, have been observed in the intraparietal sulcus (IPS) in monkeys and humans, including children. Using functional magnetic resonance imaging, we show that children as young as 3– 4 years old exhibit neural tuning to cardinal numerosities in the IPS and that their neural responses are accounted for by a model of numerosity coding that has been used to explain neural responses in the adult IPS. We also found that the sensitivity of children’s neural tuning to number in the right IPS was comparable to their numerical discrimination sensitivity observed behaviorally, outside of the scanner. Children’s neural tuning curves in the right IPS were significantly sharper than in the left IPS, indicating that numerical representations are more precise and mature more rapidly in the right hemisphere than in the left. Further, we show that children’s perceptual sensitivity to numerosity can be predicted by the development of their neural sensitivity to numerosity. This research provides novel evidence of developmental continuity in the neural code underlying numerical representation and demonstrates that children’s neural sensitivity to numerosity is related to their cognitive development.
Reproductive endocrinology Non-alcoholic fatty liver disease is associated with insulin resistance and lipid accumulation product in women with polycystic ovary syndrome

D. Macut1,*, K. Tziomalos2, I. Božić-Antić1, J. Bjekić-Macut3, I. Katsikis4, E. Papadakis4, Z. Andrić3, and D. Panidis4 Clinic of Endocrinology, Diabetes and Diseases of Metabolism, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, 54636 Thessaloniki, Greece CHC Bezanijska Kosa, Faculty of Medicine, University of Belgrade, 11080 Belgrade, Serbia Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, 54642 Thessaloniki, Greece
Feasibility study of I ΕΕΕ 802 . 11 ah radio technology for IoT and M 2 M use cases CONFERENCE

In this paper we study the feasibility of IEEE 802.11ah radio technology for internet of things (loT) and machine to machine (M2M) use cases. Devices in internet of things and machine to machine networks are foreseen to communicate wirelessly. Therefore, it is of foremost importance to have a reliable, low-energy wireless technology available that may be used anywhere and anytime without draining the device battery and could achieve satisfactory coverage and data rate. Here we study the link budget, achievable data rate and packet size design of the IEEE 802.11ah radio technology in different channel scenarios. System design and simulation results show that when using this technology the system parameters can be selected to satisfy in most of the cases a reliable communication link while providing better coverage and relatively comparable throughput when compared to other existing solutions like ZigBee.
Comparative effectiveness of nonsurgical treatment for stress urinary incontinence in adult women : a systematic review and network meta-analysis of randomized controlled trials

Objective: This study aimed to explore the most effective nonsurgical therapy to treat stress urinary incontinence (SUI). Methods: Data were pooled and the Bayesian random effects model was utilized to evaluate the inconsistencies between indirect and direct proof. Network sub-analyses, sensitivity and subgroup analysis, and standard pairwise comparisons were utilized in preparation of the main analysis. Results: A total of 17 RCTs (852 participants) were enrolled. With regard to therapy, pelvic floor muscle training (PFMT) was more often recommended than biofeedback (BF). The combination of PFMT and BF was remarkably promoted than PFMT alone or PFMT with vaginal cone (VC) or electrical stimulation (ES). The QL scores of patients who underwent PFMT were noticeably improved compared with those of patients who underwent ES. The combination of BF and PFMT was remarkably promoted compared with BF alone. VC was superior to ES with regard to QL scores. By contrast, ES alone was the least preferred method to decrease urine leakage and to promote QL. Conclusion: The combination of BF and PFMT was proven to be an optimal method to treat SUI which aims to promote urine leakage and LQ compared with either PFMT alone, ES, VC, or circular muscle (CME), while ES was the least preferred method to promote LQ.
Well-being & Pilots ’ flying : An Empirical Study on the Impact of Medical Status on Mental Health

Military aviators undergo routine medical examinations periodically to determine their fitness to fly. Aviators who are deemed unfit may experience lower levels of Subjective Well-Being (SWB) which is a relatively stable construct that deals with healthy human functioning and adjustment. SWB may have a bearing on their recovery and return to flying in addition to their mental health status. The present study aims to determine the impact of medical status on SWB of aviators. 110 military pilots participated in the study; 46 of whom were in the full category, 20 in the temporarily low medical category and 46 in the permanent grounded category. Diener’s Satisfaction With Life Scale (SWLS), WHO – 5 Well-Being Index, Watson’s Positive Affect and Negative Affect Scales (PANAS), Marlowe-Crowne Social Desirability (SD) Scale as well as a demographic inventory were administered to participants. Medical status was found to have an effect on SWB, SWLS and Negative Affect scores. On SWB, active flyers reported high scores while temporarily and permanent unfit pilots reported average scores. In general, aviators were in the average range on SWLS irrespective of medical category with active fliers reporting significantly higher quality of life compared to unfit pilots. On PANAS, all three medical categories differed significantly on levels of Negative Affect (NA) with permanently unfit pilots reporting highest scores and active fliers reporting the lowest. Conversely, the group displayed high Positive Affect (PA) irrespective of medical status. These findings validate the hypothesis that medical status has an impact on aviators’ mental health and wellbeing. The limitation of high SD among aviators especially for SWLS and PA is noted. The paper highlights the importance of uplifting SWB among aviators who are an integral part of the Indian Air Force. IJASM 2013; 57(1): 19-27
Parallel Scalar Multiplication Based on Signed Binary Representation of CRT and DRM

This is a scientific report for several issues in Parallelization elliptic curve cryptosystem based on using different signed binary representations. In this paper, we introduce the parallel implementation of elliptic curve scalar multiplication over the prime field using signed binary representations. Our implementation speeds up the calculation of scalar multiplication in comparison with the standard case. We introduce parallel algorithm for computing elliptic curve scalar multiplication based on Complementary Recoding Technique (CRT). Also we propose a parallel algorithm for computing elliptic curve scalar multiplication based on another representation which is a Direct Recording Method (DRM). Both implementations of the proposed algorithms show speedups reaching upto 60% in comparison with execution time for sequential cases of the algorithms. We find that ECC-DRM is faster than ECC-CRT in both parallel and sequential counterparts.
Masterarbeit Visualization and Analysis of Text Documents with Geographic References

In recent years automatic text recognition has gotten more accurate and large amounts of old newspaper articles have been digitised. This allows humanities researchers to use a broader range of computer-aided methods for exploration and sensemaking of this data. Researchers are investigating connections between different publication sources, such as propagation patterns of news. However, they are limited in their pursuit of insight by a lack of tools for exploration and management of such data. Especially for huge datasets, visualisation can greatly improve the search for patterns and anomalies, and help reduce the cognitive load on the user. We create an approach that provides an overview visualisation and exploration capabilities for a collection of newspaper articles, their release dates and publication locations. The approach provides cues on the geographical locations of the visualised data without having to rely on a world map as its core component, freeing up space for other parts of the visualisation. We use brushing and linking throughout the visualisation to provide more context to the user. The dataset can be drilled down into, allowing further exploration, such as filtering by date, location or used words. In an expert review with a researcher in American studies, we evaluate the usefulness of the approach and collect feedback. The general response is that the approach can be useful for researchers. Finally, we provide a discussion and an outlook on future improvements.