Miracle-dz/UniFAR-FTUs huggingface dataset:
Beamforming for IEEE 802.11b using a joint conjugate gradient multistage wiener filter.

This paper presents a joint reduced rank adaptive beamforming technique using smart antennas that can be applied to systems using direct sequence spread spectrum (DSSS), and we analyze its performance using the IEEE 802.11b signaling standard. The algorithm is based on a joint implementation of the conjugate gradient (CG) multistage Wiener filter (MWF), called the CG-MWF. This algorithm is more robust in a multiuser environment than its single user and full rank counterparts, as well as more efficient to implement, in that it requires a very low rank to adapt the beamformer weights. Multiple signals are assumed, which produce a co-channel interference (CCI) scenario. We show that the algorithm provides up to 7 dB improvement over the single user CG-MWF when the power levels of the users are similar. We demonstrate the robustness of the algorithm under dynamic conditions, such as when the number of users, their powers, and their directions-of-arrival (DoAs) change or when a user is traveling at driving speeds.
Predicting the Popularity of Online News using Gradient Boosting Machine

Popularity prediction of online news aims to predict the future popularity of news article prior to its publication estimating the number of shares, likes, and comments. Yet, popularity prediction is a challenging task due to various issues including difficulty to measure the quality of content and relevance of content to users; prediction difficulty of complex online interactions and information cascades; inaccessibility of context outside the web; local and geographic conditions; and social network properties. This paper focuses on popularity prediction of online news by predicting whether users share an article or not, and how many users share the news adopting before publication approach. This paper proposes the gradient boosting machine for popularity prediction using features that are known before publication of articles. The proposed model shows around 1.8% improvement over previously applied techniques on a benchmark dataset. This model also indicates that features extracted from articles keywords, publication day, and the data channel are highly influential for popularity prediction. Keywords—Text Mining, Social Media
Development of a Novel Measure of Overcrowding in a Pediatric Emergency Department

Objective: Emergency department (ED) overcrowding has been quantified with a scale that reflects the degree of overcrowding (National ED Overcrowding Scale, or NEDOCS) in general academic EDs. However, validity of the 5-question NEDOCS scale has not been established for a pediatric ED. Our primary objectives were to validate the NEDOCS model in our institution's pediatric ED and explore the possibility of another pediatric ED overcrowding model that would be better than the NEDOCS model. Methods: Objective data were determined by prospectively collecting 20 variables at 42 random site-sampling times in one pediatric ED. Data were obtained by counting patients, determining patient's times, and obtaining information from registration, triage, and ancillary services. The 5 questions needed for the NEDOCS scale were among the data collected. Expert consensus (EC) was obtained using a Likert scale completed by the charge nurse and ED physicians who rated the degree of overcrowding. National ED Overcrowding Scale scores were compared with EC score to determine predictive validity of a model for a pediatric ED. Spearman correlation and multivariable linear regression were used to evaluate individual variables. Results: Overcrowding based on EC score was found in 18 (44%) of 41 times in the pediatric ED. In pediatric EDs, high correlations were found between EC score and NEDOCS (0.68), number of patients in the waiting room (0.74), full rooms (0.64), and total registered patients (0.65). In a multivariable analysis, a combination of patients in the waiting room and total registered patients had a high correlation (0.80) with EC score in the pediatric ED. Conclusions: Overcrowding is quantifiable in a pediatric ED. Although the NEDOCS performed well in the pediatric ED, it was outperformed by other variables and other variable combinations. In this pediatric ED, a combination of 2 variables, total registered patients and patients in the waiting room, was a better model than the NEDOCS score for quantifying pediatric ED overcrowding.
INTESTINAL CYTOSKELETON DEGRADATION PRECEDES TIGHT JUNCTION LOSS FOLLOWING HEMORRHAGIC SHOCK

Hemorrhagic shock (HS) leads to intestinal barrier loss, causing systemic inflammation, which in turn can ultimately lead to multiorgan dysfunction syndrome. Barrier function is based on tight junctions (TJs) between intact epithelial cells. These TJs are anchored in the cell via the filamentous actin (F-actin) cytoskeleton. We hypothesize that HS causes hypoperfusion, leading to loss of F-actin, via activation of actin-depolymerizing factor/cofilin (AC), and consequently TJ loss. This study is aimed at unraveling the changes in cytoskeleton and TJ integrity after HS in organs commonly affected in multiorgan dysfunction syndrome (liver, kidney, and intestine) and to elucidate the events preceding cytoskeleton loss. Adult rats were subjected to a nonlethal HS and sacrificed, along with unshocked controls, at 15, 30, 60, and 90 min after induction of shock. Cytoskeleton, TJ integrity loss, and its consequences were studied by assessment of globular actin, F-actin, AC, zonula occludens protein 1, claudin 3, and bacterial translocation. In the liver and kidney, TJ and the F-actin cytoskeleton remained intact at all time points studied. However, in the intestine, significant loss of F-actin and increase of globular actin was seen from 15 min after shock. This change preceded statistically significant loss of the TJ proteins claudin 3 and zonula occludens protein 1, which were observed starting at 60 min after induction of shock (P < 0.05 vs. controls). Early after induction of shock (15 and 30 min) the nonactive AC (phosphorylated AC) in the intestine was significantly decreased (by 21% and 27%, P < 0.05 vs. control), whereas total AC remained constant, reflecting an increase in activated AC in the intestine from 15 min after shock. Bacterial translocation to mesenteric lymph nodes, liver, and spleen was present from 30 min after shock. This study shows for the first time that HS results in AC activation, selective intestinal actin cytoskeleton disruption, and TJ loss very early after the onset of shock. Loss of this intestinal barrier results in translocation of toxins and bacteria, which enhances inflammation and leads to infections.ABBREVIATIONS-AC-actin-depolymerizing factor/cofilin; bpm-beats per minute; F-actin-filamentous actin; G-actin-globular actin; HR-heart rate; HS-hemorrhagic shock; LC-myosin light chain; MODS-multiorgan dysfunction syndrome; pAC-phosphorylated AC; tAC-total AC; TJ-tight junction; ZO-1-zonula occludens protein 1
Ficolin 1 Expression is Elevated in the Peripheral Blood Mononuclear Cells of Takayasu's Vasculitis Patients

Takayasu’s arteritis (TA), a form of vasculitis (angiitis), is a chronic inflammatory disease involving the large blood vessels. This study reports the identification of genes showing increased mRNA levels in peripheral blood mononuclear cells (PBMCs) from TA patients regardless of symptoms or disease activity/inactivity. Of these, mRNA for Ficolin 1 (FCN1) showed a four-fold increase in all eight TA patients examined. Increased FCN1 mRNA levels observed in cDNA microarrays were confirmed by quantitative reverse transcription polymerase chain reaction. Increased FCN1 protein expression was also observed in inflamed regions of the surgical aorta specimens. Moreover, most FCN1-positive cells were also positive for CD68, indicating the presence of monocytic cells, such as macrophages or dendritic cells, which attack infectious agents within the inflamed regions. Taken together, the results suggest that FCN1 mRNA levels in peripheral blood samples may be a diagnostic marker for TA.
Sampling in-library book use

Although a large number of book usage studies have been conducted in the past, very little is known about in‐library (unrecorded) use. This may be due to the lack of a “good” method of sampling in‐library use. Here, a plan for sampling in‐library use is presented which attempts to avoid the pitfalls of the earlier methods. According to this plan, the library is divided into a certain number of areas, and a sample of monographs within each area is selected for study. Inspection rounds are then made on each of the days of the survey period. The sequence in which different areas of the library are surveyed is determined at random for every round. During each round an investigator goes through the book shelves and determines which sample monographs are away from their positions on shelves. This plan yields an unbiased estimate of a proposed index of in‐library use for any specified group of books. A hypothetical example is provided to explain the proposed plan.
Anti-CD48 (murine CD2 ligand) mAbs suppress cell mediated immunity in vivo.

With the identification of murine CD48 as a homolog of the human CD2 ligand LFA-3 (CD58) and as a ligand itself for murine CD2, the anti-murine CD48 mAb HM48-1 was administered intravenously to investigate the role of CD48 in cell mediated immunity in vivo. Anti-CD48 mAb diminished the contact sensitivity response to the hapten trinitrophenol (TNP). mAb also inhibited in vivo priming for the subsequent generation of secondary, TNP-specific, cytotoxic T lymphocytes (CTL) in vitro. The inhibitory effect was most effective in the afferent or inductive phase of immunity for CTL, while anti-CD48 mAb was most inhibitory for the efferent or elicitative phase of contact sensitivity. Addition of anti-CD48 mAb directly to secondary CTL cultures also completely inhibited CTL generation, while addition to the lytic assay showed only minimal inhibition of CTL activity. Combining cells from mAb treated and untreated animals showed no evidence for suppressor cells. Further experiments revealed that mAb administered in vivo, as well as to culture, inhibited development of primary, alloantigen-specific CTL in vitro. Mixed lymphocyte reaction and phytohemagglutinin proliferation were partially suppressed by mAb administered in vivo or in vitro, whereas other mitogenic responses remained unaffected. Flow cytometric analysis revealed a moderate down modulation of CD48, CD3 and CD8 after treatment with anti-CD48. However, this did not represent T cell depletion since CD2, Thy-1.2 and Ig expression did not change. These results support a major unrecognized role for CD48 in diverse aspects of cell mediated immunity, affecting both CD4+ and CD8+ effector T cell function. (ABSTRACT TRUNCATED AT 250 WORDS)
Specially Structured Uncapacitated Facility Location Problems

This paper considers a specially structured uncapacitated facility location problem. We show that several problems, including certain tool selection problems, substitutable inventory problems, supplier sourcing problems, discrete lot sizing problems, and capacity expansion problems, can be formulated as instances of the problem. We also show that the problem with m facilities and n customers can be solved in O(mn), as a shortest path problem on a directed graph.
ADHD in adults: A study of clinical characteristics, impairment and comorbidity

In this study, we explored the clinical characteristics, impairment and comorbidity in a sample of 45 adult patients with attention-deficit/hyperactivity disorder (ADHD). The collection of data is based on a naturalistic, retrospective approach using medical records documenting a comprehensive assessment of the patients. The sample was severely impaired in terms of academic achievement, employment and criminality, and had very high levels of comorbidity, especially alcohol and drug abuse, antisocial personality disorder and depression. Despite a high degree of contact with child psychiatric services in childhood, very few were diagnosed with ADHD, and many had a long period of psychiatric treatment as adults before the ADHD diagnosis was made. ADHD is in this sample of adults associated with severe impairment and comorbidity, and the connection between impairment and lack of proper diagnosis and treatment is discussed.
Epidermal nerve fiber density in sensory ganglionopathies: Clinical and neurophysiologic correlations

We assessed the involvement of somatic unmyelinated fibers in sensory ganglionopathies by skin biopsy and quantitative sensory testing (QST). Sixteen patients with ganglionopathy, 16 with axonal neuropathy, and 15 normal controls underwent skin biopsy at the proximal thigh and the distal leg. Intraepidermal nerve fibers (IENF) were immunostained by antiprotein gene product 9.5, and their linear density was quantified under light microscopy. Confocal microscopy studies with double staining of nerve fibers and basement membrane were also performed. Healthy subjects and neuropathy patients showed the typical proximodistal gradient of IENF density; in neuropathies, values were significantly lower at the distal site of the leg, confirming the length‐dependent loss of cutaneous innervation. Conversely, ganglionopathy patients with hyperalgesic symptoms did not show any change of IENF density between the proximal thigh and the distal leg. The distinct pattern of epidermal denervation seen in sensory ganglionopathy reflected the degeneration of somatic unmyelinated fibers in a fashion that was not length‐dependent, which was consistent with both clinical and neurophysiologic observations and supported the diagnosis. © 2001 John Wiley & Sons, Inc. Muscle Nerve 24: 1034–1039, 2001
Predicting Imbalanced Taxi and Passenger Queue Contexts in Airport

The taxi and passenger queue contexts indicate the various states of queues related to taxis and passengers (i.e. taxis are waiting for passengers, passengers are waiting for taxis, both are waiting for each other, none is waiting). Predicting these queue contexts in a future time is very important for better airport ground transport operations. However, queue context prediction at the airport is a challenging problem due to the presence of different contextual factors i.e., time, weather, taxi trips, flight arrivals and many more. Also these taxi and passenger queue contexts at the airport are imbalanced since some of the contexts are very infrequently occurring compared to others. In this paper, we address the problem of predicting imbalanced taxi and passenger queue contexts at the airport. First, we investigate different contextual factors, including time, taxi trips, passengers and weather for queue context prediction. Then we propose a detailed step by step solution to address this problem. To support the effectiveness of our detailed approach, we generate a queue context dataset by fusing three real world datasets including taxi trip, passenger wait time and weather condition that represent the taxi and passenger queue contexts at a major international airport in the New York City. The experimental results demonstrate that our developed queue context prediction framework provides detailed solutions to deliver higher accuracy in queue context prediction.
Roles of Ca2+ and F-actin in intracellular aggregation of Chlamydia trachomatis in eucaryotic cells

The effect of intracellular free Ca2+ ([Ca2+]i) on the intracellular aggregation of Chlamydia trachomatis serovars L2 and E in McCoy and HeLa cells is investigated. Loading the cells with the Ca2+ chelator MAPT/AM (1,2-bis-5-methyl-amino-phenoxylethane-N,N-n'-tetra-acetoxymethyl acetate), thereby decreasing the [Ca2+]i from 67 to 19 nM, decreased the number of cells with a local aggregation of chlamydiae in a dose-dependent manner. Neither the attachment nor the uptake of elementary bodies (EBs) was, however, affected after depletion of Ca2+ from the cells. There was no significant difference in the level of measured [Ca2+]i between infected and uninfected cells. Reducing the [Ca2+]i also significantly inhibited chlamydial inclusion formation. Differences in the organization of the actin filament network were observed in response to [Ca2+]i depletion. In Ca(2+)-depleted cells, where few EB aggregates were formed, few local accumulations of F-actin were observed in the cytosol. These results suggest that the aggregation of EBs in eucaryotic cells requires a normal homeostasis of intracellular Ca2+. By affecting F-actin reorganization and putatively certain Ca(2+)-binding proteins, [Ca2+]i plays a vital role in the infectious process of chlamydiae.
Channel estimation based on delay-subspace filter for uplink of CDM-OFDMA system

In this paper, an uplink channel estimation scheme based on subspace filter is proposed for B3G CDM-OFDMA systems. This algorithm utilizes the slow varying multi-path delay sub-space to decrease the noise of LS estimation It requires fewer pilot sub-carriers than other algorithms and is practical because of its low complexity. So this scheme is very suitable for B3G system uplink since there are too many user channel parameters needed to estimate. Simulation results demonstrate that it Is an effective scheme for the multi-carrier system in the uplink
PERFORMANCE IMPROVEMENT USING ADAPTIVE LEARNING ITINERARIES

In this paper, Bayesian‐Networks (BN) and Ant Colony Optimization (ACO) techniques are combined to find the best path through a graph representing all available itineraries to acquire a professional competence. The combination of these methods allows us to design a dynamic learning path, useful in a rapidly changing world. One of the most important advances in this work is that the amount of pheromones released is variable. This amount is calculated by taking into account the results acquired in the last completed course in relation to the minimum score required.
Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine*

Cells can respond to DNA damage by activating checkpoints that delay cell cycle progression and allow time for DNA repair. Chemical inhibitors of the G2 phase DNA damage checkpoint may be used as tools to understand better how the checkpoint is regulated and may be used to sensitize cancer cells to DNA-damaging therapies. However, few inhibitors are known. We used a cell-based assay to screen natural extracts for G2checkpoint inhibitors and identified debromohymenialdisine (DBH) from a marine sponge. DBH is distinct structurally from previously known G2 checkpoint inhibitors. It inhibited the G2checkpoint with an IC50 of 8 μm and showed moderate cytotoxicity (IC50 = 25 μm) toward MCF-7 cells. DBH inhibited the checkpoint kinases Chk1 (IC50 = 3 μm) and Chk2 (IC50 = 3.5 μm) but not ataxia-telangiectasia mutated (ATM), ATM-Rad3-related protein, or DNA-dependent protein kinase in vitro, indicating that it blocks two major branches of the checkpoint pathway downstream of ATM. It did not cause the activation or inhibition of different signal transduction proteins, as determined by mobility shift analysis in Western blots, suggesting that it inhibits a narrow range of protein kinases in vivo.
Football Injuries at Asian Tournaments

Purpose To examine the incidences and patterns of injuries that required medical attention among Asian football players. Methods A total of 411 Asian football players at both senior and youth (U-20) elite levels were observed during 50 international matches. Independent injury observers and team doctors determined the occurrence of injuries and recorded the location, type, time, and circumstances of the injuries using a protocol sheet. Results The overall injury frequency rate was 45.8 out of 1000 hours. As the tournaments progressed into the knockout stages, the incidence and severity of the injuries increased. The most common sites of injuries were the knees (18.5%), lower legs (17.3%), and ankles (14.2%). Although most injuries were diagnosed as contusions, the more serious injuries were those diagnosed as sprains (especially concerning the knee and ankle) or strains (thigh and back). Conclusions The incidences of injuries to Asian football players were higher than those to European players, but the patterns of the injuries showed no major differences. Clinical Relevance To develop an injury-prevention program, more solid and comprehensive data need to be collected to identify the risk factors and variables associated with higher incidences of injuries to Asian football players.
TOKAMAK REACTOR SYSTEM ANALYSIS CODE FOR THE CONCEPTUAL DEVELOPMENT OF DEMO REACTOR

Tokamak reactor system analysis code was developed at KAERI (Korea Atomic Energy Research Institute) and is used here for the conceptual development of a DEMO reactor. In the system analysis code, prospects of the development of plasma physics and the relevant technology are included in a simple mathematical model, i.e., the overall plant power balance equation and the plasma power balance equation. This system analysis code provides satisfactory results for developing the concept of a DEMO reactor and for identifying the necessary R&D areas, both in the physics and technology areas for the realization of the concept. With this system analysis code, the performance of a DEMO reactor with a limited extension of the plasma physics and technology adopted in the ITER design. The main requirements for the DEMO reactor were selected as: 1) demonstrate tritium self-sufficiency, 2) generate net electricity, and 3) achieve a steady-state operation. It was shown that to access an operational region for higher performance, the main restrictions are presented by the divertor heat load and the steady-state operation requirements.