Miracle-dz/UniFAR-FTUs huggingface dataset:
Different Cognitive Correlates of Early Learning of Spelling of Different Target Types in Korean Hangul Among First Language Children and Adult Foreign Language Learners

This study examined whether different cognitive correlates are associated with spelling of different target types, such as phonologically consistent and inconsistent syllables, of Korean Hangul among 94 five-year-old first language (L1) Korean children and 41 foreign language (FL) learners who are Hong Kong Chinese college students. Korean children performed tasks of spelling, along with measures of syllable and phoneme coda awareness, phonological and orthographic working memory, morphological awareness, vocabulary, and orthographic knowledge. Among Korean 5-year-old children, coda awareness and orthographic working memory explained unique variance in spelling of phonologically consistent syllables, whereas syllable and coda awareness, orthographic working memory, orthographic knowledge, and vocabulary all explained unique variance in spelling of inconsistent syllables. When Chinese college students were tested on spelling of Korean Hangul as a foreign language, along with a battery of tasks in Korean similar to those administered to the L1 children, only orthographic working memory significantly explained spelling of consistent syllables, whereas only vocabulary knowledge explained spelling of inconsistent syllables. In both groups, spelling accuracy was lower in phonologically inconsistent than in consistent Hangul syllables. These findings suggest that different cognitive demands are involved in early spelling of phonologically consistent and inconsistent syllables in Korean Hangul among L1 and FL learners.
Joint effects of alcohol and stimulant use disorders on self-reported sexually transmitted infections in a prospective study of Cambodian female entertainment and sex workers

Female entertainment and sex workers (FESW) have high rates of alcohol and amphetamine-type stimulant (ATS) use, increasing risk for HIV/sexually transmitted infections (STI), and other negative outcomes. A prospective cohort of 1,198 FESW in a HIV/ATS use prevention intervention in Cambodia was assessed for alcohol and stimulant use disorders (AUD and SUD) using the Alcohol and Substance Use Involvement (ASSIST) scale. STI history was measured by self-report at baseline and at quarterly follow-up visits. Participants were asked if they had been diagnosed with an STI by a medical provider in the past 3 months. Marginal structural models were used to estimate joint effects of AUD and SUD on recent STI. At baseline, one-in-four screened AUD positive and 7% screened positive for SUD. At 18-months, 26% reported ≥1 recent STI. Accounting for time-varying and other known confounders, the adjusted odds ratio (AOR) for recent STI associated with AUD alone and SUD alone were 2.8 (95% CI:1.5–5.1) and 3.5 (95% CI:1.1–11.3), respectively. The AOR for joint effects of AUD and SUD was 5.7 (95% CI:2.2–15.2). AUD and SUD are independently and jointly associated with greater odds of STI among Cambodian FESW. Further research is critical for understanding how AUD and SUD potentiate biological and behavioural pathways that influence STI acquisition and to inform HIV risk-reduction interventions in FESW.
The cost-effectiveness of once-weekly semaglutide compared with other GLP-1 receptor agonists in type 2 Diabetes: a systematic literature review

ABSTRACT Introduction: As a novel glucagon-like peptide-1receptor agonist (GLP-1 RA) for type 2 diabetes (T2D) treatment, the economic value of once-weekly semaglutide had been assessed in several country settings. The authors’ objective was to systematically review the existing pharmacoeconomic literature evaluating the cost-effectiveness associated with once-weekly semaglutide compared with other GLP-1 RAs and provide implications for further researches. Areas covered: We conducted a systematic literature review of cost-effectiveness analysis (CEA) published up to 25 July 2020 in PubMed, web of science, and the ISPOR presentation database, compared once-weekly semaglutide with other GLP-1 RAs in T2D. Nineteen studies were identified, including 8 short-term and 11 long-term studies. General characteristics and main results of the included studies were summarized. Expert opinion: This review provided references for other countries to overview the value of once-weekly semaglutide compared with other GLP-1 RAs in T2D in the healthcare decision-making process and to conduct their CEA studies associated with once-weekly semaglutide. The authors found that the cardiovascular (CV) benefit of once-weekly semaglutide was under-estimated in current studies and suggested that the methods of economic evaluations for novel anti-diabetic drugs with CV benefit should be improved in future researches.
Clinical and radiological predictors of epidermal growth factor receptor mutation in nonsmall cell lung cancer.

PURPOSE To determine the prognostic factors of epidermal growth factor receptor (EGFR) mutation status in a group of patients with nonsmall cell lung cancer (NSCLC) by analyzing their clinical and radiological features. MATERIALS AND METHODS Patients with NSCLC who underwent EGFR mutation detection between 2014 and 2017 were included. Clinical features and general imaging features were collected, and radiomic features were extracted from CT data by 3D Slicer software. Prognostic factors of EGFR mutation status were selected by least absolute shrinkage and selection operator (LASSO) logistic regression analysis, and receiver operating characteristic (ROC) curves were drawn for each prediction model of EGFR mutation. RESULTS A total of 118 patients were enrolled in this study. The smoking index (P = 0.028), pleural retraction (P = 0.041), and three radiomic features were significantly associated with EGFR mutation status. The areas under the ROC curve (AUCs) for prediction models of clinical features, general imaging features, and radiomic features were 0.284, 0.703, and 0.815, respectively, and the AUC for the combined prediction model of the three models was 0.894. Finally, a nomogram was established for individualized EGFR mutation prediction. CONCLUSIONS The combination of radiomic features with clinical features and general imaging features can enable discrimination of EGFR mutation status better than the use of any group of features alone. Our study may help develop a noninvasive biomarker to identify EGFR mutation status by using a combination of the three group features.
Coronary microvascular function is impaired in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare inherited disease caused by NOTCH3 gene mutations. Although the main clinical features reflect brain injury, CADASIL is a systemic microangiopathy, and cardiac involvement has been observed but not systematically assessed. We aimed to study the prevalence and severity of coronary microvascular dysfunction (CMD) in CADASIL patients.
Interaction of neutrophil counts and folic acid treatment on new-onset proteinuria in hypertensive patients

Abstract We aimed to examine whether baseline neutrophil counts affected the risk of new-onset proteinuria in hypertensive patients, and, if so, whether folic acid treatment is particularly effective in proteinuria prevention in such a setting. A total of 8208 eligible participants without proteinuria at baseline were analysed from the renal substudy of the China Stroke Primary Prevention Trial. Participants were randomised to receive a double-blind daily treatment of 10 mg of enalapril and 0·8 mg of folic acid (n 4101) or 10 mg of enalapril only (n 4107). The primary outcome was new-onset proteinuria, defined as a urine dipstick reading of ≥1+ at the exit visit. The mean age of the participants was 59·5 (sd, 7·4) years, 3088 (37·6 %) of the participants were male. The median treatment duration was 4·4 years. In the enalapril-only group, a significantly higher risk of new-onset proteinuria was found among participants with higher neutrophil counts (quintile 5; ≥4·8 × 109/l, OR 1·44; 95 % CI 1·00, 2·06), compared with those in quintiles 1–4. For those with enalapril and folic acid treatment, compared with the enalapril-only group, the new-onset proteinuria risk was reduced from 5·2 to 2·8 % (OR 0·49; 95 % CI 0·29, 0·82) among participants with higher neutrophil counts (≥4·8 × 109/l), whereas there was no significant effect among those with neutrophil counts <4·8 × 109/l. In summary, among hypertensive patients, those with higher neutrophil counts had increased risk of new-onset proteinuria, and this risk was reduced by 51 % with folic acid treatment.
Physiology of maerl algae: Comparison of inter‐ and intraspecies variations

Free‐living red coralline algae play an important role in the carbon and carbonate cycles of coastal environments. In this study, we examined the physiology of free‐living coralline algae‐forming maerl beds in the Bay of Brest (Brittany, France), where Lithothamnion corallioides is the dominant maerl (i.e., rhodolith) species. Phymatolithon calcareum and Lithophyllum incrustans are also present (in lower abundances) at a specific site in the bay. We aimed to assess how maerl physiology is affected by seasonality and/or local environmental variations at the inter‐ and intraspecific levels. Physiological measurements (respiration, photosynthetic, and calcification rates) were performed using incubation chambers in winter and summer to compare (1) the dominant maerl species at three sites and (2) three coexisting maerl species at one site. Comparison of the three coexisting maerl species suggests that L. corallioides is the best adapted to the current environmental conditions in the Bay of Brest, because this species is the most robust to dissolution in the dark in winter and has the highest calcification efficiency in the light. Comparisons of L. corallioides metabolic rates between stations showed that morphological variations within this species are the main factor affecting its photosynthetic and calcification rates. Environmental factors such as freshwater inputs also affect its calcification rates in the dark. In addition to interspecies variation in maerl physiology, there were intraspecific variations associated with direct (water physico‐chemistry) or indirect (morphology) local environmental conditions. This study demonstrates the plasticity of maerl physiology in response to environmental changes, which is fundamental for maerl persistence.
Long-Term Determinants of the Seroprevalence of Toxoplasma gondii in a Wild Ungulate Community

Simple Summary Toxoplasma gondii is a zoonotic intracellular parasite which infects a wide range of warm-blooded animals. Long-term studies provide the necessary perspective required to understand those processes which took place over many years in order to address epidemiology and ecology in complex host communities. This study is focused on evaluating what the main long-term determinants of the seroprevalence of T. gondii are in the wild ungulate community from Doñana National Park (southwestern Spain). With this purpose, we assayed sera from 1573 wild ungulates (wild boar, red deer, and fallow deer), collected for 13 years (from 2005 to 2018). We found high seroprevalence values of T. gondii (% ± CI 95%; wild boar 39 ± 3.3; red deer 30.7 ± 4.4; and fallow deer 29.7 ± 4.2. Several factors operating in the medium and long-term (individual, environmental, population and stochastic) explained the risk of T. gondii in wild boar and deer, some of them operating at the community level. Abstract Toxoplasma gondii is an obligate intracellular protozoan which infects warm-blooded vertebrates, including humans, worldwide. In the present study, the epidemiology of T. gondii was studied in the wild ungulate host community (wild boar, red deer, and fallow deer) of Doñana National Park (DNP, south-western Spain) for 13 years (2005–2018). We assessed several variables which potentially operate in the medium and long-term (environmental features, population, and stochastic factors). Overall, the wild ungulate host community of DNP had high seroprevalence values of T. gondii (STG; % ± confidence interval (CI) 95%; wild boar (Sus scrofa) 39 ± 3.3, n = 698; red deer (Cervus elaphus) 30.7 ± 4.4, n = 423; fallow deer (Dama dama) 29.7 ± 4.2, n = 452). The complex interplay of hosts and ecological/epidemiological niches, together with the optimal climatic conditions for the survival of oocysts that converge in this area may favor the spread of the parasite in its host community. The temporal evolution of STG oscillated considerably, mostly in deer species. The relationships shown by statistical models indicated that several factors determined species patterns. Concomitance of effects among species, indicated that relevant drivers of risk operated at the community level. Our focus, addressing factors operating at broad temporal scale, allows showing their impacts on the epidemiology of T. gondii and its trends. This approach is key to understanding the epidemiology and ecology to T. gondii infection in wild host communities in a context where the decline in seroprevalence leads to loss of immunity in humans.
Efficacy of low-level laser therapy combined with exercise for subacromial impingement syndrome: A randomised controlled trial

Objective: To investigate the effect of low-level laser therapy (LLLT) combined with exercise on shoulder pain and disability in patients with subacromial impingement syndrome (SIS). Design: Randomised controlled trial. Setting: Pontifical Catholic University. Subjects: We enrolled 120 subacromial impingement syndrome patients Intervention: Groups I (n = 42), II (n = 42) and III (n = 36) were treated with Low-level laser therapy and exercise, exercise only and Low-level laser therapy only, respectively. Interventions were conducted three times a week for 8 weeks. Main outcome measures: The primary outcome was the change in shoulder pain and disability index (SPADI). Secondary outcomes included changes in the numeric pain rating scale and medication intake. Results: Average ages of patients in groups I, II and III were 51.9 ± 8.7 years, 56.0 ± 10.4 years and 54.2 ± 7.1 years, respectively. Pain scores at baseline (P = 0.829), 2 months (P = 0.057) and 3 months follow-ups (p = 0.004) were 6.8 (4.7–7.7), 0.2 (0.0–0.5) and 0.3 (0.0–1.0) for group I; 6.6 (5.7–8.0), 0.5 (0.2–2.0) and 0.2 (0.0–3.3) for group II; and 6.5 (5.1–7.4), 2.4 (0.1–6.7) and 4.0 (2.0–5.0) for group III, respectively. SPADI scores at baseline (P = 0.029), 2 months (P < 0.001) and 3 months follow-ups (P = 0.001) were 60.8 (37.7–70.8), 3.8 (0.0–10.8) and 2.3 (0.8–10.8) for group I; 61.5 (41.5–71.5), 9.2 (3.8–29.2) and 14.2 (1.5–38.0) for the group II; and 73.3 (59.2–80.8), 34.2 (16.9–54.6) and 33.1 (22.3–49.2) for the group III, respectively. Conclusion: Low-level laser therapy combined with exercises reduce pain intensity, improve shoulder function and reduces pain intensity and medication intake over 3 months. Clinical Trial Registration number: NCT 02725749
A molecular marker of milk composition traits in NCAM2 gene of Chinese Holstein

Abstract The aim of this study was to detect the novel copy number variation (CNV) locus of NCAM2 gene in Chinese Holstein, and to analyze the effect of the novel CNV locus in NCAM2 gene on milk composition traits. The novel CNV locus of NCAM2 gene in 310 Chinese Holstein was detected by real-time quantitative fluorescent PCR (qPCR) and association analysis was performed between the novel CNV locus in NCAM2 gene and milk composition traits in Chinese Holstein. There are three CNV types of NCAM2 gene in Chinese Holstein: gain (increased copy number), median (normal copy number) and loss (deleted copy number). Statistical analysis revealed that there was a significant association between CNV types and milk fat rate (p < 0.05). Moreover, we also discovered that the milk production and milk protein rate of gain type is higher than that of loss type, but that of mediate type is lower than that of loss type. However, in terms of somatic cell score, loss type is higher than that of gain type, but that of mediate type is lower than that of gain type. These observations suggested that gain type can be used as a candidate molecular genetic marker of milk fat rate. Highlights The CNVs of the NCAM2 gene were detected and validated in Chinese Holstein. The type of CNV was successfully implemented using qPCR. The statistical analysis indicated that the CNV of the NCAM2 gene are significantly associated with milk fat rate.
A spiking model of basal ganglia dynamics in stopping behavior supported by arkypallidal neurons

The common view that stopping action plans by the basal ganglia is achieved mainly by the subthalamic nucleus alone due to its direct excitatory projection onto the output nuclei of the basal ganglia has been challenged by recent findings. The proposed “pause‐then‐cancel” model suggests that the subthalamic nucleus provides a rapid stimulus‐unspecific “pause” signal, followed by a stop‐cue‐specific “cancel” signal from striatum‐projecting arkypallidal neurons. To determine more precisely the relative contribution of the different basal ganglia nuclei in stopping, we simulated a stop‐signal task with a spiking neuron model of the basal ganglia, considering recently discovered connections from the arkypallidal neurons, and cortex‐projecting GPe neurons. For the arkypallidal and prototypical GPe neurons, we obtained neuron model parameters by fitting their neuronal responses to published experimental data. Our model replicates findings of stop‐signal tasks at neuronal and behavioral levels. We provide evidence for the existence of a stop‐related cortical input to the arkypallidal and cortex‐projecting GPe neurons such that the stop responses of the subthalamic nucleus, the arkypallidal neurons, and the cortex‐projecting GPe neurons complement each other to achieve functional stopping behavior. Particularly, the cortex‐projecting GPe neurons may complement the stopping within the basal ganglia caused by the arkypallidal and STN neurons by diminishing cortical go‐related processes. Furthermore, we predict effects of lesions on stopping performance and propose that arkypallidal neurons mainly participate in stopping by inhibiting striatal neurons of the indirect rather than the direct pathway.
Dietary γ-Glutamylcysteine: Its Impact on Glutathione Status and Potential Health Outcomes

Abstract Glutathione (GSH) is a tripeptide that is readily synthesized intracellularly in humans and other mammals. More than a century of research suggests that GSH has numerous biological functions, including protection from the potential adverse events associated with reactive oxygen species (ROS) and related redox reactions that may induce oxidative stress, and that may be linked to innate detoxification processes. Normal tissue and plasma levels of GSH decline through the aging process and decrease during various disease states. While the health value of dietary GSH remains controversial, there is evidence that some metabolic intermediates, such as γ-glutamylcysteine (GGC) may function to preserve adequate GSH levels when the synthetic pathways decline in activity, and the innate antioxidant system is challenged. It is also important to recognize that among the thousands of protein-coding human genes and their respective polymorphisms, at least two genes (Gclc and Gclm) are directly involved with GSH synthesis via glutamate-cysteine ligase. This commentary examines the classic biochemistry, toxicology, safety, and clinical value of GSH and its intermediates that may be modulated by dietary supplementation.
Formation of cobalt(II) complexes with five pyridine oximes in aqueous solution

Complex formation equilibria of cobalt(II) with pyridine-2-carboxamidoxime (1), pyridine-2-acetamidoxime (2), pyridine-2-aldoxime (3), 1-(2-pyridinyl)ethanone oxime (4) and 6-methylpyridine-2-aldoxime (5) were studied in 0.1 M NaCl solution at 25°C by potentiometric titrations with use of a glass electrode. Experimental data were analysed with the least-squares computer program SUPERQUAD to determine the complexes formed and their stability constants. With ligands 1−4 Co(II) forms mono, bis and (except for 2) tris complexes of the type and deprotonated/hydrolyzed products of the bis and tris complexes, Co(HL)L+ and Co(HL)2L+. The deprotonated complexes have a low spin structure (t 2 g 6 e g ) and are readily oxidized after the easy loss of the sole e g electron. Their formation with increasing pH involves slow attainment of equilibrium in the pH range 3−5. Only with ligand 3 could studies be continued to pH 8−10 by using very low cobalt(II) ion concentrations. There, CoL2 is formed quantitatively, while complexes Co(HL)L2 and could not be observed. Ligand 1 also forms the complex Co2(HL)2H2L5+ and ligand 2 the complex Co(H2L)3+ with the positively charged ligand (H2L+). Ligand 5 forms the complexes Co(HL)2+, CoL2, Co2L2OH+, and Co2L3OH mainly in the pH range 6−10. The stabilities of these complexes and also their oxidation reactions are reduced by the steric requirements of the 6-methyl groups of the ligand.
Knockdown-Mortality Responses of Six Stored-Product Beetle Species on Different Surfaces Treated With Thiamethoxam, Using a Standardized Lethality Index

Abstract Bioassays were conducted to evaluate the effectiveness of thiamethoxam in different surfaces, against six stored-grain insects, Sitophilus granarius (L.) (Coleoptera: Curculionidae), Sitophilus oryzae (L.) (Coleoptera: Curculionidae), Tribolium confusum Jacquelin du Val (Coleoptera: Tenebrionidae), Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae), Cryptolestes ferrugineus (Stephens) (Coleoptera: Laemophloeidae), and Oryzaephilus surinamensis (L.) (Coleoptera: Silvanidae). Six different surfaces (concrete, plywood, galvanized steel, linen, plastic, and ceramic tile) treated with thiamethoxam at 0.05 and 0.1 mg/cm2 were used as substrate for adult exposure. Knockdown was recorded after 1, 3, and 7 d of exposure to the treated surface, in order to calculate a Standardized Lethality Index (SLI). Knockdown counts were ranked from ‘0' to ‘4’, with ‘0' representing adult insects ‘moved generally' and ‘4’ representing dead insects. Based on the results, insect knockdown seems leading to mortality than to recovery and the SLI ranking of the target species according to their susceptibility to thiamethoxam showed that S. granarius being more susceptible and decreasing susceptibility in an order of S. oryzae > T. castaneum ≥ O. surinamenis ≥ C. ferrugineus ≥ T. confusum. In general, among the surfaces, thiamethoxam efficacy was lower on linen, wooden, and concrete surfaces, as compared to metallic and plastic surfaces. Nevertheless, at the end of 7-d exposure, all surfaces equally affected thiamethoxam toxicity.
A Low-Profile End-Fire Conformal Surface Wave Antenna with Capacitive Feed Structure

A high end-fire gain, low-profile surface wave antenna with capacitive feed structure is presented in this paper. The proposed dielectric-metal surface wave antenna is composed of a dielectric slab that is mounted on a metal carrier and a low-profile feed structure. The feed structure is composed of a monopole radiation pin that is loaded with a circular metal plate and a grounding pin. The profile height of the antenna is only one-tenth of the operating wavelength. With a good end-fire performance and low profile, the antenna is very suitable to be conformally mounted on the surface of flight vehicles. The proposed antenna was designed and manufactured at the center frequency of 6 GHz. Measured results demonstrated that the proposed antenna had a bandwidth of 7.33%, ranging from 5.89 to 6.33 GHz, and the antenna reached a high gain of 9.76 dBi with a length of 122.96 mm (2.45 λ) in the end-fire direction.