Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical evaluation and quantitative analysis of axillary hyperhidrosis treated with a unique targeted laser energy delivery method with 1-year follow up.

BACKGROUND Primary Focal Axillary Hyperhidrosis (PHH) is a chronic disorder of excessive underarm sweat that causes significant impairment of an individual's daily activities. Multiple studies have established the psychosocial burden of PHH and its negative impact on quality of life. Current first-line therapies include the use of topical aluminum chloride with limited efficacy. Second line therapy includes the use of Botulinum toxin, which is effective, but duration is limited to 6-7 months. OBJECTIVE The purpose was to evaluate the long term efficacy and safety of the Nd:YAG 1440 nm wavelength with a unique delivery fiber (SideLaze) and the Smartlipo TriPlex device (Cynosure Inc). METHODS Fifteen subjects were recruited to an approved Institutional Review Board study. Outcome measures were comprised of clinical and quantitative evaluation of functional impairment. This included HDSS scale, physician and subject evaluation, and digital photography of before and after starch iodine tests utilizing image processing and analysis software. Subjects received a single treatment and were evaluated at 1 week and at 3, 6, and 12 months post treatment. Responders were defined as those that scored an HDSS score of 1 or 2 post-treatment. Those that were non-responsive at 6 months received a second treatment. RESULTS All patients responded to treatment with 72% reporting a two-point HDSS score improvement and 28% reporting a 1-point improvement at 1-year follow-up. The average HDSS score improvement was 1.9/3.0. Three of the 15 patients at 6 months received a second treatment. The HDSS average score for all patients remained statistically stable at 1-year follow-up. CONCLUSIONS Treatment of axillary hyperhidrosis with the 1440 nm Nd:YAG-pulsed laser combined with a targeted fiber and temperature-sensing device provides a safe and minimally invasive approach to the treatment of axillary hyperhidrosis with minimal side effects and long-term efficacy.
Understanding the relationship between weight loss, emotional well-being and health-related quality of life in patients attending a specialist obesity weight management service

This study explored predictors of clinically meaningful improvement in health-related quality of life (HRQOL) among obese patients completing a specialist weight management programme. One hundred and ninety-nine adults aged from 20–88 with a BMI >30 with comorbidities or BMI>35 with/without comorbidities were sampled. The results suggested that both weight loss and changes in depression were significant predictors of HRQOL improvement. However, predictors differed between weight loss groups. Clinically meaningful improvement in HRQOL was found to be due to weight loss when participants had lost 5 kg or more in weight. In contrast, among individuals who lost 0.1–4.9 kg, improvement in HRQOL was accounted for by positive changes in depression scores.
The Use of Prosody in Highlighting Alterations in Repairs from Unrestricted Speech

A speaker has several ways in which he or she may highlight the fact that an error or imprecision of speech has been made and subsequently altered. The three principal ones are by signalling through the structure of the speech that surrounds the error (the repair-syntax), by the use of prosody, and through the semantic content. The role of prosody in the correction process is investigated in the current studies. Analysis of the prosody of a number of errors and their alterations drawn from unrestricted speech are reported. The analysis shows that pauses occur at the moment of interruption and that an increase in stress occurs at the start of the alteration. Pauses could indicate the moment of interruption, and stress could highlight what has been altered. Two sets of perceptual experiments were carried out to assess whether these cues are salient for listeners who hear constructions containing an error and its alteration. Two paradigms were employed in each set of experiments: (1) direct judgement about the comprehensibility of sentences containing errors and alterations, and (2) repeating a message that had an error and alteration without the error. The effects of stress and pauses on (Experiments 1A and 1B) or pauses around (Experiment 2A and 2B) the alterations were assessed. In the first set of experiments it was shown that pauses and stress help listeners process repairs. When a word is spoken in error, the speaker may repeat a section of speech immediately preceding the alteration and/or a section immediately following that word. Inclusion of these repeated sections allows assessment of whether pauses signal where the interruption occurred. The second experiment shows that the placing of the pause before the retrace, rather than at other locations, indicates to listeners where the repair starts.
Characterization of FGFRL1, a Novel Fibroblast Growth Factor (FGF) Receptor Preferentially Expressed in Skeletal Tissues*

Clones for a novel transmembrane receptor termed FGFRL1 were isolated from a subtracted, cartilage-specific cDNA library prepared from chicken sterna. Homologous sequences were identified in other vertebrates, including man, mouse, rat and fish, but not in invertebrates such as Caenorhabditis elegans and Drosophila. FGFRL1 was expressed preferentially in skeletal tissues as demonstrated by Northern blotting and in situ hybridization. Small amounts of the FGFRL1 mRNA were also detected in other tissues such as skeletal muscle and heart. The novel protein contained three extracellular Ig-like domains that were related to the members of the fibroblast growth factor (FGF) receptor family. However, it lacked the intracellular protein tyrosine kinase domain required for signal transduction by transphosphorylation. When expressed in cultured cells as a fusion protein with green fluorescent protein, FGFRL1 was specifically localized to the plasma membrane where it might interact with FGF ligands. Recombinant FGFRL1 protein was produced in a baculovirus system with intact disulfide bonds. Similar to FGF receptors, the expressed protein interacted specifically with heparin and with FGF2. When overexpressed in MG-63 osteosarcoma cells, the novel receptor had a negative effect on cell proliferation. Taken together our data are consistent with the view that FGFRL1 acts as a decoy receptor for FGF ligands.
Measurement of coherent scattering form factors using an image plate

Two new methods for measuring x-ray coherent scattering form factors using an image plate were developed based on a matrix representation of the problem. The methods were tested experimentally using tube potentials of 50, 70 and 92 kV and different filtrations. Water and fat samples were measured and compared to data in the literature. For water, average absolute relative differences between 0.105 and 0.217 were measured when compared to the literature. Literature data for fat show a wide range of values. Our measured values were in the middle of the literature data range with average absolute relative differences between 0.126 and 0.528. The accuracy of the matrix methods was limited by the ill-conditioning of the problem and also experimentally by the limitations of our equipment. The matrix methods developed are shown to be relatively low resolution in momentum transfer parameter and limited to measurements on amorphous materials such as tissues where the attenuation of the x-ray beam is small. These methods, however, can be used to measure form factors with relatively inexpensive, clinical equipment.
A Behavior Genetic Analysis of Trait Emotional Intelligence and Alexithymia: A Replication

This replication study examines relations between alexithymia and trait emotional intelligence (trait EI) at the phenotypic, genetic, and environmental levels. A sample of 1,444 same-sex twin pairs (850 MZ pairs and 594 DZ pairs) completed the Toronto Alexithymia Scale-20. A subset of 494 same-sex twin pairs (287 MZ pairs and 207 DZ pairs) had earlier completed the Trait Emotional Intelligence Questionnaire. Individual differences in alexithymia were attributable to genetic, non-shared environmental, and shared environmental factors. All but one of the facets of alexithymia were negatively and significantly correlated with the factors of trait EI, and these phenotypic correlations were entirely attributable to correlated genetic and correlated non-shared environmental factors. These bivariate results provide a valuable replication of those of Baughman et al. (Twin Research and Human Genetics, Vol. 14, 2011, pp. 539–543), which was conducted with substantially smaller samples of twins.
The anatomy, affinity, and phylogenetic significance of Markuelia

Summary The fossil record provides a paucity of data on the development of extinct organisms, particularly for their embryology. The recovery of fossilized embryos heralds new insight into the evolution of development but advances are limited by an almost complete absence of phylogenetic constraint. Markuelia is an exception to this, known from cleavage and pre‐hatchling stages as a vermiform and profusely annulated direct‐developing bilaterian with terminal circumoral and posterior radial arrays of spines. Phylogenetic analyses have hitherto suggested assignment to stem‐Scalidophora (phyla Kinorhyncha, Loricifera, Priapulida). We test this assumption with additional data and through the inclusion of additional taxa. The available evidence supports stem‐Scalidophora affinity, leading to the conclusion that scalidophorans, cyclonerualians, and ecdysozoans are primitive direct developers, and the likelihood that scalidophorans are primitively metameric.
A RUSSIAN BIOELECTRIC-CONTROLLED PROSTHESIS: REPORT OF A RESEARCH TEAM FROM THE REHABILITATION INSTITUTE OF MONTREAL.

1. WENNER, H. A. : Ann. N.Y. Acad. Sci., 101: 398, 1962. 2. HAMMON, W. M. et al.: Proc. Soc. Exp. Biol. Med., 103: 164, 1960. 3. MELNICK, 3. L. et aL: Science, 141: 153, 1963. 4. WENNER, H. A. et al.: Amer. ,f. Hyg. , 78: 247, 1963. 5. LENNETTE, E. H. et al.: New Eng. J. Med., 266: 1358, 1962. 6. VON MAGNUS, H. : Quoted by Wenner, H. A. et aL: Amer. J. Hyg. , 78: 258, 1963. 7. COOPER, M. R. et al.: Canad. Med. An,. J., 84: 200, 1961. 8. KELEN, A. E. et al.: Ibid., 89: 921, 1963.
Kaposi Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 and Multiple Myeloma in South Africa

Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) has been implicated in the etiopathogenesis of multiple myeloma. Although the association is biologically plausible and attractive, conflicting data have been reported, including evidence against the involvement of KSHV in the pathogenesis of the disease. The purpose of this study was to determine the relationship between KSHV and myeloma in blacks in South Africa, in whom the disease is not uncommon and the seroprevalence of KSHV is higher than in the areas in which this association has been documented. Using a nested polymerase chain reaction (PCR) assay, the authors initially tested for the presence of KSHV DNA sequences (KS330233) in bone marrow aspirates, bone marrow biopsy material, and cultured bone marrow adherent cell samples of patients with myeloma. KSHV DNA sequences were detected in 4 of 10 (40%) of the adherent cell cultures and 1 of 20 (5%) of the bone marrow aspirate samples. None of the bone marrow biopsy samples (0/9) or control bone marrow aspirate samples (0/19) was positive. To confirm the positive results in the bone marrow cultures noted above and to exclude contamination, the procedure was repeated in a further 7 patients with myeloma and 11 controls with lymphoproliferative disorders using the same nested PCR assay. In addition, the authors used a different set of primers that recognize sequences internal to the 233-bp fragment to yield a final product of 186 bp. The authors were unable to detect any KSHV DNA sequences in the patients with myeloma (0/7) or the control patients with other lymphoproliferative disorders (0/11). Taken together, the finding of a positive result in 4 of 17 patients (23.5%), which is similar to the background seroprevalence rate, does not support a clear association between myeloma and KSHV in blacks in South Africa.
Global estimates for mixed methods for second order elliptic equations

Global error estimates in L2(92), L? (9), and H-s(Q), 2 in R2 or a, re derived for a mixed finite element method for the Dirichlet problem for the elliptic operator Lp = div(a grad p + bp) + cp based on the Raviart-Thomas-Nedelec space Vh x Wh c H(div; 92) x L2(g2). Optimal order estimates are obtained for the approximation of p and the associated velocity field u = -(a grad p + bp) in L2(g2) and H-s(92), 0 6 s < k + 1, and, if Q c R2, forp in LV2().
Optimization of dynamic motions for legged robots

Legged robots and animals can exhibit a variety of locomotory skills, trotting and walking being the most widely used modes of locomotion. Such behaviours are often defined with the overall stability of the system in mind and are inherently of periodic nature. Legged robots, possibly equipped with arms as well, in everyday scenarios, e.g. service or forestry/agriculture, will require also skills that are not of periodic nature but rather better described as single-shot manoeuvres.
Mean square average-consensus for multi-agent systems with measurement noise and time delay

Mean square average consensus for multi-agent systems with measurement noise and time delay under fixed digraph is studied in this article. The time-varying consensus-gain is introduced to attenuate the measurement noise. By combining the tools of algebraic graph theory, matrix theory and stochastic analysis, consensus protocols for multi-agent systems with measurement noise and time delay are elaborately analysed. The example and simulation results are given to illustrate the effectiveness of the obtained theoretical results. Moreover, the simulations demonstrate that, the proper consensus-gain function in the consensus protocol is the necessary and sufficient condition for the convergence of the multi-agent systems.
Stimulated amplification of UV emission in a femtosecond filament using adaptive control

We report on experimental results in adaptive control over UV fluorescence from a femtosecond filament created in nitrogen. We demonstrate that an optimized sequence of femtosecond pulses can effectively align, selectively ionize and excite molecular nitrogen ions, resulting in stimulated amplification of a filament continuum seeded emission at 391 nm, 358 nm and 428 nm wavelengths.
Neuroprotection by Manganese Superoxide Dismutase (MnSOD) Mimics: Antioxidant Effect and Oxidative Stress Regulation in Acute Experimental Stroke

Manganese superoxide dismutase (MnSOD), one of the most crucial antioxidant enzymes in the central nervous system, is thought to be one of the major mechanisms by which cells counteract the injuries of reactive oxygen species after cerebral ischemia. In this study, we used a novel synthesized compound (MnTm4PyP) with highly effective superoxide dismutase activity to study the therapeutic potential of MnSOD and the possible underlying mechanisms in cerebral ischemia.
Authentication Protocol using Fuzzy Eigenface Vault based on MoC

In this paper, the eigenface-based fuzzy vault scheme, called a fuzzy eigenface vault, is designed and examined, and authentication protocol using the fuzzy eigenface vault is designed based on a smartcard and analyzed security of the proposed authentication protocol. Especially, face recognition for user authentication has several advantages such as natural, nonintrusive, convenience, and easy to use. However, it is difficult to apply biometrics on cryptographic security because of different images in each acquisition phase. Furthermore face data can be vulnerable to modification attack and illegally let out. From that, the need of secure biometrics authentication methods has been increased and we propose a new authentication protocol using fuzzy eigenface vault and smart card. The proposed protocol has three advantages compared to previous works. First, to get security, accuracy and convenience without reluctance at same time, we use eigenface in a fuzzy vault scheme which is suitable to combine biometric authentication and cryptography. Second, to enhance security, secret data which is for construction of the fuzzy eigenface vault is saved on a smart card. Third, to reduce a transmission-based attack, a transmission of message is occurred just one time in a login phase.
Monte Carlo calculated stopping-power ratios, water/air, for clinical proton dosimetry (50-250 MeV).

Calculations of stopping power ratios, water to air, for the determination of absorbed dose to water in clinical proton beams using ionization chamber measurements have been undertaken using the Monte Carlo method. A computer code to simulate the transport of protons in water (PETRA) has been used to calculate sw.air-data under different degrees of complexity, ranging from values based on primary protons only to data including secondary electrons and high-energy secondary protons produced in nonelastic nuclear collisions. All numerical data are based on ICRU 49 proton stopping powers. Calculations using primary protons have been compared to the simple continuous slowing-down approximation (c.s.d.a.) analytical technique used in proton dosimetry protocols, not finding significant differences that justify elaborate Monte Carlo simulations except beyond the mean range of the protons (the far side of the Bragg peak). The influence of nuclear nonelastic processes, through the detailed generation and transport of secondary protons, on the calculated stopping-power ratios has been found to be negligible. The effect of alpha particles has also been analysed, finding differences smaller than 0.1% from the results excluding them. Discrepancies of up to 0.6% in the plateau region have been found, however, when the production and transport of secondary electrons are taken into account. The large influence of nonelastic nuclear interactions on proton depth-dose distributions shows that the removal of primary protons from the incident beam decreases the peak-to-plateau ratio by a large factor, up to 40% at 250 MeV. It is therefore emphasized that nonelastic nuclear reactions should be included in Monte Carlo simulations of proton beam depth-dose distributions.
Las poblaciones caribeñas desde el tercer milenio aC a la conquista española: las filiaciones biológicas desde la perspectiva antropológica dental

El objetivo de esta investigacion es analizar los rasgos morfologicos dentales para determinar la filiacion y el origen de grupos humanos caribenos. Las colecciones datan de los periodos de pre-contacto y contacto espanol. Los resultados apuntan hacia la separacion entre ambas poblaciones y una distancia biologica de los dos grupos.
T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells

The liver has an established ability to induce tolerance. Recent evidence indicates that this unique property might be related to its distinctive architecture allowing T cells to be activated in situ independently of lymphoid tissues. Unlike lymph node–activated T cells, liver‐activated T cells are short‐lived, a mechanism that might contribute to the “liver tolerance effect. ” Although the potential role of hepatocytes as tolerogenic antigen‐presenting cells has been demonstrated, the question as to whether these cells are able to interact with CD8+ T cells in physiological settings remains controversial. Contradicting the immunological dogma stating that naïve T lymphocytes are prevented from interacting with parenchymal cells within non‐lymphoid organs by an impenetrable endothelial barrier, we show here that the unique morphology of the liver sinusoidal endothelial cell (LSEC) permits interactions between lymphocytes and hepatocytes. Using electron microscopy, we demonstrate that liver resident lymphocytes as well as circulating naïve CD8+ T cells make direct contact with hepatocytes through cytoplasmic extensions penetrating the endothelial fenestrations that perforate the LSECs. Furthermore, the expression of molecules required for primary T cell activation, MHC class I and ICAM‐1, is polarized on hepatocytes to the perisinusoidal cell membrane, thus maximizing the opportunity for interactions with circulating lymphocytes. In conclusion, this study has identified, at the ultrastructural level, a unique type of interaction between naïve T lymphocytes and liver parenchymal cells in vivo. These results hold implications for the pathogenesis of viral hepatitis in which hepatocytes may represent the main antigen‐presenting cell, and for the development of immune tolerance as lymphocytes pass through the liver. (HEPATOLOGY 2006;44:1182–1190.)
Mnestic performance profile of a bilateral diencephalic infarct patient with preserved intelligence and severe amnesic disturbances.

The case of a patient with above-average intelligence and educational background, high motivation, and an approximate IQ-MQ difference of 40 points is documented. The patient has been examined repeatedly for nearly a decade. Extensive neuroradiological material of his focal bilateral brain damage in the dorsal diencephalon is available. A widespread range of cognitive tests was used to investigate his actual performance on all relevant aspects of intelligence, attention, subjective memory, immediate retention, learning, skill and problem solving abilities, concept formation, cognitive flexibility, priming, constructional ability, retrograde memory, and long-term retention. The total of more than 50 tests included German-language forms of the revised Wechsler Memory Scale and of the Rivermead Behavioural Memory Test. The patient's short-term memory and attention were, in spite of his advanced years, average or well above average. He gave a number of examples of still intact skills and implicit memory abilities, though there was no uniformity in his performance on implicit memory tests (e.g., with respect to stored vs. new implicit information). He had no awareness of his severe anterograde and retrograde amnesia, documented over a large range of verbal and figural tests. Taken together, the results from our patient confirm the principal dichotomy between declarative and nondeclarative mnestic functions, but give evidence for some restrictions as well. They furthermore demonstrate that focal diencephalic damage may result in profound anterograde and selective retrograde amnesia, especially with respect to data-based material, and that disconnecting portions of the medial and basolateral limbic circuits has devastating consequences on memory.