Miracle-dz/UniFAR-FTUs huggingface dataset:
Activation of Autophagic Flux Maintains Mitochondrial Homeostasis during Cardiac Ischemia/Reperfusion Injury

Reperfusion injury after extended ischemia accounts for approximately 50% of myocardial infarct size, and there is no standard therapy. HDAC inhibition reduces infarct size and enhances cardiomyocyte autophagy and PGC1α-mediated mitochondrial biogenesis when administered at the time of reperfusion. Furthermore, a specific autophagy-inducing peptide, Tat-Beclin 1 (TB), reduces infarct size when administered at the time of reperfusion. However, since SAHA affects multiple pathways in addition to inducing autophagy, whether autophagic flux induced by TB maintains mitochondrial homeostasis during ischemia/reperfusion (I/R) injury is unknown. We tested whether the augmentation of autophagic flux by TB has cardioprotection by preserving mitochondrial homeostasis both in vitro and in vivo. Wild-type mice were randomized into two groups: Tat-Scrambled (TS) peptide as the control and TB as the experimental group. Mice were subjected to I/R surgery (45 min coronary ligation, 24 h reperfusion). Autophagic flux, mitochondrial DNA (mtDNA), mitochondrial morphology, and mitochondrial dynamic genes were assayed. Cultured neonatal rat ventricular myocytes (NRVMs) were treated with a simulated I/R injury to verify cardiomyocyte specificity. The essential autophagy gene, ATG7, conditional cardiomyocyte-specific knockout (ATG7 cKO) mice, and isolated adult mouse ventricular myocytes (AMVMs) were used to evaluate the dependency of autophagy in adult cardiomyocytes. In NRVMs subjected to I/R, TB increased autophagic flux, mtDNA content, mitochondrial function, reduced reactive oxygen species (ROS), and mtDNA damage. Similarly, in the infarct border zone of the mouse heart, TB induced autophagy, increased mitochondrial size and mtDNA content, and promoted the expression of PGC1α and mitochondrial dynamic genes. Conversely, loss of ATG7 in AMVMs and in the myocardium of ATG7 cKO mice abolished the beneficial effects of TB on mitochondrial homeostasis. Thus, autophagic flux is a sufficient and essential process to mitigate myocardial reperfusion injury by maintaining mitochondrial homeostasis and partly by inducing PGC1α-mediated mitochondrial biogenesis.
Axillary Web Syndrome in Breast Cancer Women: What Is the Optimal Rehabilitation Strategy after Surgery? A Systematic Review

Background: Axillary web syndrome (AWS) is one of the most prevalent and underrecognized disorders affecting breast cancer (BC) women. However, the optimal therapeutic strategy to manage AWS is far from being fully characterized. Therefore, this systematic review aims to provide a broad overview of the available rehabilitation treatments in this burdensome condition. Methods: On 13 January 2022, PubMed, Scopus, Web of Science, Cochrane, and PEDro were systematically searched for clinical studies assessing rehabilitation interventions in post-surgical BC women with AWS. The outcomes analyzed were pain, AWS clinical resolution, upper limb function, and health-related quality of life (HR-QoL). Results: The search identified 1115 records, of which 11 studies were included. A total of 174 patients were assessed (ages ranging from 37 and 66 years old). The interventions included manual lymphatic drainage, manual therapy, stretching, resistance training, mobilization techniques, and Kinesio tape. Positive improvements were reported in terms of pain relief (in 7 studies), AWS clinical resolution (in 9 studies), upper limb function (in 10 studies), and HR-QoL (in 2 studies). Conclusions: Our findings suggest that rehabilitation might be considered an effective therapeutic strategy in AWS patients. Further RCTs are needed to characterize the optimal rehabilitative interventions.
Construction Grammar Conceptual Network: Coordination-based graph method for semantic association analysis

Abstract In this article, we present the Construction Grammar Conceptual Network method, developed for identifying lexical similarity and word sense discrimination in a syntactically tagged corpus, based on the cognitive linguistic assumption that coordination construction instantiates conceptual relatedness. This graph analysis method projects a semantic value onto a given coordinated syntactic dependency and constructs a second-order lexical network of lexical collocates with a high co-occurrence measure. The subsequent process of clustering and pruning the graph reveals lexical communities with high conceptual similarity, which are interpreted as associated senses of the source lexeme. We demonstrate the theory and its application to the task of identifying the conceptual structure and different meanings of nouns, adjectives and verbs using examples from different corpora, and explain the modulating effects of linguistic and graph parameters. This graph approach is based on syntactic dependency processing and can be used as a complementary method to other contemporary natural language processing resources to enrich semantic tasks such as word disambiguation, domain relatedness, sense structure, identification of synonymy, metonymy, and metaphoricity, as well as to automate comprehensive meta-reasoning about languages and identify cross/intra-cultural discourse variations of prototypical conceptualization patterns and knowledge representations. As a contribution, we provide a web-based app at http://emocnet.uniri. hr/.
Analisis Sentimen Review Hotel Menggunakan Algoritma Naïve Bayes Classifier

Abstrak- Wisatawan saat melakukan pemesanan hotel seringkali mengalami kesulitan dalam menentukan hotel mana yang akan dipilih. Traveloka merupakan salah satu situs pemesanan hotel yang memiliki berbagai fitur bagi pengunjung dalam menentukan hotel yang akan dipilih. Salah satu fitur tersebut adalah ulasan yang menampilkan berbagai komentar pengunjung tentang suatu hotel. Akan tetapi semakin banyak komentar tentang suatu hotel maka pengunjung membutuhkan waktu yang lama untuk membaca dan memilih hotel yang diinginkan. Berdasarkan permasalahan tersebut, maka dibutuhkan analisis sentimen yang dapat mengolah sejumlah komentar untuk memperoleh informasi yang bermanfaat bagi pengunjung. Sistem analisis sentimen yang dibangun memiliki tujuan membuat model sentimen untuk menentukan ulasan komentar suatu hotel. Proses analisis sentimen dilakukan dengan menggunakan algoritma Pengklasifikasi Naive Bayes . Hasil pengujian bahwa klasifikasi sentimen menggunakan Naïve Bayes Classifier memperoleh hasil akurasi sebesar 90,61%, presisi sebesar 93,03%, recall sebesar 89,52% dan f-measure sebesar 90,99%.
Music Emotion Recognition Based on Bilayer Feature Extraction

Music is a kind of art which is to express the thoughts and emotion and reflect the reality life by organized sounds; every piece of music expresses emotions through lyrics and melodies. Human emotions are rich and colorful, and there are also differences in music. It is unreasonable for a song to correspond to only one emotional feature. According to the results of existing algorithms, some music has obviously wrong category labels. To solve the above problems, we established a two-layer feature extraction model based on a spectrogram from shallow to deep (from primary feature extraction to deep feature extraction), which can not only extract the most basic musical features but also dig out the deep emotional features. And further classify the features with the improved CRNN neural network, and get the final music emotion category. Through a large number of comparative experiments, it is proven that our model is suitable for a music classification task.
Probabilistic Rolling-Optimization Control for Coordinating the Operation of Electric Springs in Microgrids With Renewable Distributed Generation

Electric spring (ES) is a novel smart grid technology developed to facilitate the integration of renewable generation by controlling the demand of non-critical loads (NCLs). The utilization of ES to provide a single service such as voltage or frequency regulation, validated in a setup consisting of a single ES, has been extensively investigated. However, to take full advantage of this technology, it is necessary to develop control strategies to coordinate the operation of multiple distributed ESs to provide multiple services in power systems. To this end, this paper presents a rolling-optimization control strategy to coordinate the operation of multiple ESs for voltage regulation, congestion management and cost minimization of the real-time deviations from the scheduled energy exchanges with the grid in microgrids with renewable generation. The strategy is for centralized implementation, and includes a probabilistic optimal power flow-based optimization engine that finds the voltage references of ESs for each control interval taking into account generation variability and uncertainties. NCLs consist of electric water heaters, which are modeled taking into account physical constraints and the hot water demand. Simulations were carried out in two test systems with 14 and 33 buses.
Effect of IAA Addition and Some Organic Supplements on Growth and Rooting of Cavendish Banana (Musa Acuminata, AAA) In-Vitro

In vitro propagation of Cavendish banana is an alternative to produce healthy, uniform and sufficient plant materials of high qualities. Appropriate culture media formulation is needed for shoot growth and rooting stage. This experiment aimed to study effects of IAA and organic supplements on in vitro shoot growth and rooting. Explants were subjected to MS medium with IAA and various organic supplements, in a factorial arrangement of a completely randomized design. The first factor was IAA concentrations (0; 0.5; 1 and 1.5 mg.L-1), and the second factor was types of organic supplement (control, coconut water, potato extract and banana extract). At 8 weeks after planting, shoot growth and root performance of plantlets were recorded. The results showed that addition of IAA did not affect shoot height. Addition of potato extract and banana homogenate resulted in the highest plantlets. Medium with IAA at 1 mg.L-1 resulted in the highest number of roots. The highest number of shoots was produced on media with IAA 1 mg.L-1 + coconut water and IAA 1.5 mg.L-1 + potato extract. The highest number of roots was produced in medium with potato extract. The longest roots were produced in media with 0.5 mg.L-1 IAA + banana homogenate. Keywords: Banana extract, Cavendish, Coconut water, IAA, Potato extract
“I Don’t Think Kids Nowadays Feel Like They Have a Lot of Power”: Exploring Teacher Civic Commitments in a National Online Letter Writing Project

This study investigates teacher participation in a national online youth civic letter writing project through the lens of teacher civic commitments. Drawing on in-depth interviews and survey data from teachers who participated in the Letters to the Next President 2.0 project, civic commitments are articulated through civic beliefs, learning goals, instructional enactments, and geopolitical context. With a generic shared belief in “youth voice,” teachers enacted the civic letter writing project through instructional activities that included (a) choice of topic, (b) publication, (c) reading letters from other youth, (d) research, (e) peer dialogue, and (f) connections beyond the Letters project. While beliefs appeared widely shared, divergence in learning goals and enactments led to distinct learning opportunities for students. With minimal research exploring the role of teachers in student civics learning, this study provides new insights to guide teacher preparation and ongoing teacher development in the realm of civics education.
State-Dependent Symbol-Wise Decode and Forward Codes Over Multihop Relay Networks

This paper studies low-latency streaming codes for the multi-hop network. The source transmits a sequence of messages to a destination through a chain of relays, and requires the destination to reconstruct each message by its deadline. We assume that each communication link is subjected to a certain maximum number of packet erasures. The case of a single relay (a three-node network) was considered in Fong et al. (2020). A coding scheme known as symbol-wise decode and forward was proposed. In the present work, we propose an alternative scheme that is different from Fong et al. (2020) and still achieves the same rate as in Fong et al. (2020) for the one hop case as the field-size goes to infinity. Furthermore, our proposed scheme naturally generalizes to the case of multiple-relay nodes yielding new achievable rates for this setting. The main difference with Fong et al. (2020) is that our proposed scheme exploits the ability of the relay nodes to adapt the transmission based on the erasures on the previous link. Hence, we refer to our scheme as “state-dependent” and contrast it with the scheme in Fong et al. (2020) that is state-independent. Our scheme requires the relay nodes to append a header to the transmitted packets, and we show that the size of the header does not depend on the field-size of the code. We also derive an upper bound on the maximal streaming rate achievable over a network with an arbitrary number of relays. We show that this upper bound matches our achievable rate in the special case when the maximal number of erasures on the first link is greater than or equal to the maximal number of erasures on each of the following links, and the field size goes to infinity.
An ethnographic study of communication with HIV-infected children at Rumah Cemara

This study examines the ethnography studies of communication with HIV-infected children at Rumah Cemara Bandung by reviewing the elements of communication components. This research uses a qualitative approach with an ethnographic type of communication study. The research subjects were children infected with HIV in Bandung who was selected using the purposive method. Data were obtained through in-depth interviews, participatory observation, document analysis, and literature study. The results revealed that the genre in the communication component of children infected with HIV at Rumah Cemara was seen in the delivery of problems, namely the presence of viral infections in children. The setting that occurs in the communication component is carried out at the child's home/residence and Rumah Cemara as a community location and Klinik Teratai, Hasan Sadikin Hospital, Bandung. Children use Indonesian and Sundanese as their daily languages. All HIV-infected children are infected with the virus because it is transmitted from their parents, namely the mother, and the mother is infected with HIV from her husband. Conversations that are usually carried out by informants when meeting at Klinik Teratai, Rumah Cemara, and at home are usually related to conditions of health development, children's adherence to taking anti-retroviral drugs, and mental and social development of children with messages of mutual encouragement and support as well as instilling a sense of optimism. Psychologically among People With HIV/AIDS (ODHA). The non-verbal language that children do in the form of silence; smiles; a nod of the head; shaking of the head, and laughing out loud.
Unraveling the Transcriptional Dynamics of NASH Pathogenesis Affecting Atherosclerosis

The prevalence of non-alcoholic steatohepatitis (NASH) is rapidly increasing and associated with cardiovascular disease (CVD), the major cause of mortality in NASH patients. Although sharing common risk factors, the mechanisms by which NASH may directly contribute to the development to CVD remain poorly understood. The aim of this study is to gain insight into key molecular processes of NASH that drive atherosclerosis development. Thereto, a time-course study was performed in Ldlr−/−. Leiden mice fed a high-fat diet to induce NASH and atherosclerosis. The effects on NASH and atherosclerosis were assessed and transcriptome analysis was performed. Ldlr−/−. Leiden mice developed obesity, hyperlipidemia and insulin resistance, with steatosis and hepatic inflammation preceding atherosclerosis development. Transcriptome analysis revealed a time-dependent increase in pathways related to NASH and fibrosis followed by an increase in pro-atherogenic processes in the aorta. Gene regulatory network analysis identified specific liver regulators related to lipid metabolism (SC5D, LCAT and HMGCR), inflammation (IL1A) and fibrosis (PDGF, COL3A1), linked to a set of aorta target genes related to vascular inflammation (TNFA) and atherosclerosis signaling (CCL2 and FDFT1). The present study reveals pathogenic liver processes that precede atherosclerosis development and identifies hepatic key regulators driving the atherogenic pathways and regulators in the aorta.
Internet Addiction and Polish Women’s Sexual Functioning: The Role of Social Media, Online Pornography, and Game Use during the COVID-19 Pandemic—Online Surveys Based on FSFI and BSMAS Questionnaires

In this study, we investigated the relationship between social media use and women’s sexual functioning during the COVID-19 pandemic. Data were collected between April and November 2021. Online surveys including the Female Sexual Functioning Index (FSFI) and Bergen Social Media Addiction Scale (BSMAS) questionnaires were distributed to young, sexually active women. Information was collected on their demographics, sexual life, and use of social media. We enrolled 546 women (mean age 23.07 ± 4.69). In general, 5.68% of the women were at high risk of social media addiction. Social media addiction had a negative impact on FSFI scores, while pornography use had a positive effect on women’s sexual functioning. Users of dating apps also obtained lower FSFI scores than non-users. No differences in FSFI scores were observed between gamers and non-gamers. The impact of time spent on social media on FSFI scores was not significant. We conclude that social media addiction negatively affected women’s sexual functioning during the COVID-19 pandemic.
Fluorescence imaging-guided photothermal therapy of asymmetric water-soluble pentamethine cyanine for colorectal cancer

The combination of advanced optical technology and tumor treatment has developed into a selectively targeted tumor therapy strategy. Near-infrared (NIR) cyanine derivative has recently received increasing attention in photothermal therapy (PTT) because of its excellent biocompatibility, non-immunogenicity, high fluorescence and photothermal conversion efficiency, photostability, and tumor-homing. In this study, an asymmetric and water-soluble pentamethine cyanine was designed and synthesized to investigate the photosensitive activity and to explore its potential applications as a NIR photosensitizer for the diagnosis and therapy of colorectal cancer (CRC). The results of fluorescence imaging analysis showed that CY5-664 preferentially accumulated in the tumor as time elapsed, and the maximum fluorescence intensity was obtained at 24 h. Cell viability and animal xenograft model experiments showed that CY5-664 significantly inhibited tumor growth in vivo with 0.8 W/cm2 of 660 nm red laser pointer for 2 min, and in vitro with 0.5 W/cm2 of 660 nm red laser pointer for 2 min. In vitro and in vivo photothermal conversion experiments showed that CY5-664 exhibited an anti-CRC activity mainly through the PTT effect. Therefore, this work provides experimental evidence that CY5-664 is a drug candidate for CRC treatment mainly through the PTT effect and an alternative treatment strategy to develop a pentamethine cyanine-based CRC theranostic photosensitizer for synergistic CRC targeting, imaging, and therapy.
Analysis of the Influence of De-hazing Methods on Vehicle Detection in Aerial Images

—In recent years, object detection from space in adverse weather, incredibly foggy, has been challenging. In this study, we conduct an empirical experiment using two de-hazing methods: DW-GAN and Two-Branch, for removing fog, then evaluate the detection performance of six advanced object detectors belonging to four main categories: two-stage, one-stage, anchor-free and end-to-end in original and de-hazed aerial images to find the best suitable solution for vehicle detection in foggy weather. We use the UIT-DroneFog dataset, a challenging dataset that includes a lot of small, dense objects captured in various altitudes, as the benchmark to evaluate the effectiveness of approaches. After experiments, we observe that each de-hazing method has different impacts on six experimental detectors.
Automated Generation and Evaluation of JMH Microbenchmark Suites From Unit Tests

Performance is a crucial non-functional requirement of many software systems. Despite the widespread use of performance testing, developers still struggle to construct and evaluate the quality of performance tests. To address these two major challenges, we implement a framework, dubbed <italic>ju2jmh</italic>, to automatically generate performance microbenchmarks from JUnit tests and use mutation testing to study the quality of generated microbenchmarks. Specifically, we compare our <italic>ju2jmh</italic> generated benchmarks to manually written JMH benchmarks and to automatically generated JMH benchmarks using the AutoJMH framework, as well as directly measuring system performance with JUnit tests. For this purpose, we have conducted a study on three subjects (<monospace>Rxjava</monospace>, <monospace>Eclipse-collections</monospace>, and <monospace>Zipkin</monospace>) with <inline-formula><tex-math notation="LaTeX">$\sim$</tex-math><alternatives><mml:math><mml:mo>∼</mml:mo></mml:math><inline-graphic xlink:href="tang-ieq1-3188005.gif"/></alternatives></inline-formula>454K <italic>source lines of code</italic> (SLOC), 2,417 JMH benchmarks (including manually written and generated AutoJMH benchmarks) and 35,084 JUnit tests. Our results show that the <italic>ju2jmh</italic> generated JMH benchmarks consistently outperform using the execution time and throughput of JUnit tests as a proxy of performance and JMH benchmarks automatically generated using the AutoJMH framework while being comparable to JMH benchmarks manually written by developers in terms of tests’ stability and ability to detect performance bugs. Nevertheless, <italic>ju2jmh</italic> benchmarks are able to cover more of the software applications than manually written JMH benchmarks during the microbenchmark execution. Furthermore, <italic>ju2jmh</italic> benchmarks are generated automatically, while manually written JMH benchmarks require many hours of hard work and attention; therefore our study can reduce developers’ effort to construct microbenchmarks. In addition, we identify three factors (too low test workload, unstable tests and limited mutant coverage) that affect a benchmark's ability to detect performance bugs. To the best of our knowledge, this is the first study aimed at assisting developers in fully automated microbenchmark creation and assessing microbenchmark quality for performance testing.