Miracle-dz/UniFAR-FTUs huggingface dataset:
Feasibility and Patient Experiences Of Method Of Levels Transdiagnostic Therapy In An Acute Mental Health Inpatient Setting

This study sought to investigate the feasibility and acceptability of a flexible psychotherapeutic approach - the Method of Levels (MOL) - in an acute mental health inpatient setting. A multi methods approach was used. The feasibility of implementation was investigated by examining the referral rate and the attendance patterns of participants. The acceptability of MOL was explored using a thematic analysis of participant interviews and by recording attendance patterns of participants. Inpatient staff consistently referred patients and the majority of eligible people accepted invitations for therapy. Thematic analysis of peoples’ experiences of the therapy generated themes that described participants’ experience s of MOL in contrast to routine NHS care, having spent meaningful time with the therapist, and having gained something from the session. The referral rate and uptake of MOL therapy indicates that the resource was appropriate for the setting and acceptable to most participants. Qualitative analyses indicated that participants were comfortable with the therapists' approach, felt understood, and there was a meaningful quality to their interaction. Participants also valued the opportunity to reflect and generate new perspectives of their difficulties. Further research is required to determine the effectiveness of the approach and its translational value beyond this pilot investigation.
Sputtered-anodized Ta2O5 as the dielectric layer for electrowetting-on-dielectric

—Evaluating the anodized tantalum pentoxide ( Ta 2 O 5 ) that has been recently reported as a dielectric for low-voltage electrowetting-on-dielectric (EWOD) devices, we ﬁnd a severe deterioration in perfor- mance if the working liquid is actuated with positive dc voltage. In an effort to reduce the limitation of this otherwise attractive dielectric material for EWOD, proposed herein is a Ta 2 O 5 layer prepared by anodizing a sputtered Ta 2 O 5 ﬁlm. This sputtered–anodized Ta 2 O 5 allows the use of positive dc signals, while maintaining the low-voltage actuation for which the anodized Ta 2 O 5 was originally introduced. All the EWOD tests were performed with a conductive liquid droplet in an air environment. [2012-0254]
Lip Motion based Alphabet Recognition using Neural Network

: The facial expressions in image sequence deliver information in context to the subject spoken by the speaker but it adds a challenge when it to be represented in animation system. It has great impact in the field of audio-visual speech recognition (AVSR). Some of us are capable of Lip reading by interpreting the lip motion. This research is divided into two-levels: (i) Firstly, frames are taken and features are extracted from these frames to be kept in database as standard. (ii) Secondly, test image samples to be trained in neural network to check the alphabet spoken with the trained images (stored in database) to recognize what the person has spoke. Lip reading system has been developed using K-Means Clustering using input images and 60% success has been achieved in similar alphabets lip movements (such as u, o, q, b, e, i, l, n etc.).
African Swine Fever Virus Blocks the Host Cell Antiviral Inﬂammatory Response through a Direct Inhibition of PKC- (cid:2) -Mediated p300 Transactivation (cid:1)

During a viral infection, reprogramming of the host cell gene expression pattern is required to establish an adequate antiviral response. The transcriptional coactivators p300 and CREB binding protein (CBP) play a central role in this regulation by promoting the assembly of transcription enhancer complexes to speciﬁc promoters of immune and proinﬂammatory genes. Here we show that the protein A238L encoded by African swine fever virus counteracts the host cell inﬂammatory response through the control of p300 transactivation during the viral infection. We demonstrate that A238L inhibits the expression of the inﬂammatory regulators cyclooxygenase-2 (COX-2) and tumor necrosis factor alpha (TNF- (cid:1) ) by preventing the recruitment of p300 to the enhanceosomes formed on their promoters. Furthermore, we report that A238L inhibits p300 activity during the viral infection and that its amino-terminal transactivation domain is essential in the A238L-mediated inhibition of the inﬂammatory response. Importantly, we found that the residue serine 384 of p300 is required for the viral protein to accomplish its inhibitory function and that ectopically expressed PKC- (cid:2) completely reverts this inhibition, thus indicating that this signaling pathway is disrupted by A238L during the viral infection. Furthermore, we show here that A238L does not of 384, located within this domain.
p38 MAP kinase regulates IL-1 b responses in cultured airway smooth muscle cells

and Stephanie A. Shore. p38 MAP kinase regulates IL-1 b responses in cultured airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 279: L932–L941, 2000. —We have previously reported that interleukin (IL)-1 b causes b -adrenergic hyporesponsiveness in cultured human airway smooth muscle (HASM) cells by increasing cyclooxygenase (COX)-2 expression. The purpose of this study was to determine whether p38 mitogen-activated protein (MAP) kinase is involved in these events. IL-1 b (2 ng/ml for 15 min) increased p38 phosphorylation fourfold. The p38 inhibitor SB-203580 (3 m M) decreased IL-1 b -induced COX-2 by 70 6 7% ( P , 0.01). SB-203580 had no effect on PGE 2 release in control cells but caused a signiﬁcant (70–80%) reduction in PGE 2 release in IL-1 b -treated cells. IL-1 b increased the binding of nuclear proteins to the oligonucleotides encoding the consensus sequences for activator protein (AP)-1 and nuclear factor (NF)- k B, but SB-203580 did not affect this binding, suggesting that the mechanism of action of p38 was not through AP-1 or NF- k B activation. The NF- k B inhibitor MG-132 did not alter IL-1 b -induced COX-2 expression, indicating that NF- k B activation is not required for IL-1 b -induced COX-2 expression in HASM cells. IL-1 b attenuated isoproterenol-induced decreases in HASM stiffness as measured by magnetic twisting cytometry, and SB-203580 abolished this effect. These results are consistent with the hypothesis that p38 is involved in the signal transduction pathway through which IL-1 b induces COX-2 expression, PGE 2 release, and b -adrenergic hyporesponsiveness. scintillation counting and for b -galactosi-dase activity by spectrophotometry with the b -galactosidase enzyme assay system (Promega). The results of the experiments are reported as mean luciferase activity normalized to b -galactosidase activity. With this system, the transfection efﬁciency averaged 16.4 6 2.8% ( n 5 5 experiments) as assessed by ﬂow cytometry of cells transfected with a green ﬂuorescence protein-expressing vector.
CMAR_A_243767 8757..8771

1Department of Nuclear Medicine, Xiasha Branch of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China; 2Department of Nuclear Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China Background: LncRNAs play important roles in papillary thyroid carcinoma (PTC). LINC02471 has been reported to be related to PTC prognosis. The current study aimed to investigate the effects of LINC02471 on human PTC cells. Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to examine LINC02471 expression in PTC tissues and cells and miR-375 expression in PTC cells. SiLINC02471, miR-375 mimic and miR-375 inhibitor were used for cell transfection. Cell proliferation, apoptosis, migration, and invasion were detected by performing Cell Counting Kit-8 (CCK-8), clone formation assay, flow cytometry, scratch assay, and transwell assay. Western blot was carried out to detect protein levels of E-cadherin, N-cadherin and Snail. The target gene for LINC02471 was verified by dual-luciferase reporter assay. Results: LINC02471 was highly expressed in PTC tissues and cells. After silencing LINC02471, cell proliferation, migration and invasion were reduced, but cell apoptosis was increased. SiLINC02471 increased the expressions of E-cadherin and miR-375, and inhibited the expressions of N-Cadherin and Snail. LINC02471 directly targeted miR-375 in PTC cells. Overexpression of miR-375 inhibited the proliferation, migration, invasion of PTC cells and reduced the expressions of N-Cadherin and Snail but promoted the cell apoptosis and increased E-cadherin expression, while miR-375 inhibitor produced opposite effects to overexpressed miR-375. After inhibiting miR-375 expression, siLINC02471 reversed the effect of miR-375 inhibitor. Conclusion: LINC02471 could promote the development of PTC. Knocking down LINC02471 could inhibit invasion and metastasis and promote PTC cell apoptosis through directly targeting miR-375.
Electron capture with He2+, Li3+, Be4+ and B5+ projectiles from atomic hydrogen

Electron capture from atomic hydrogen into orbitals of fully stripped ions (helium to boron) is investigated at impact velocities between 0.3 and 1.4 au. The authors report the summed total cross sections for electron capture into the states of the incident nucleus, obtained by solution of the time-dependent Schrodinger equation in terms of a basis set of the Hylleraas type with a straight-line approximation for the nuclear motion.
AABC_A_258759 25..47

Barcelona Institute for Global Health (ISGlobal), Hospital Clínic – University of Barcelona, Barcelona, 08036, Spain Abstract: Neglected tropical diseases are infectious diseases that impose high morbidity and mortality rates over 1.5 billion people worldwide. Originally restricted to tropical and subtropical regions, changing climate conditions have increased their potential to emerge elsewhere. Control of their impact suffers from shortages like poor epidemiological surveillance or irregular drug distribution, and some NTDs still lack of appropriate diagnostics and/ or efficient therapeutics. For these, availability of vaccines to prevent new infections, or the worsening of those already established, would mean a major breakthrough. However, only dengue and rabies count with approved vaccines at present. Herein, we review the state-ofthe-art of vaccination strategies for NTDs, setting the focus on third generation vaccines and the concept of reverse vaccinology. Its capability to address pathogens ́ biological complexity, likely contributing to save developmental costs is discussed. The use of computational tools is a fundamental aid to analyze increasingly large datasets aimed at designing vaccine candidates with the highest, possibly, opportunities to succeed. Ultimately, we identify and analyze those studies that took an in silico approach to find vaccine candidates, and experimentally assessed their immunogenicity and/or protection capabilities.
Finite modelling of tow geometry in 3D woven fabrics. Composites

A finite element model of a 3D woven angle interlock fabric undergoing compaction based on the multi-element digital chain technique has been developed. The aim of this study was to create a kinematic model to predict the internal architectural features of a 3D woven fabric in a commercial off-the-shelf code. The model geometry was created in MSC. Patran and is run in the explicit finite element software LS-Dyna. A statistical analysis of yarn crimp and resin channel size was carried out on sections from the model at increasing levels of compaction and compared to Resin Transfer Moulded (RTM) manufactured samples of 3D woven fabric with the same weave style. Results show a good correlation between overall mean crimp values in the warp, weft and weaver yarns as well as reasonable accuracy in the frequency distribution of local crimp angles. The trend in resin channel size with respect to increasing levels of compaction was also good but significant discrepancies in the absolute dimensions of a resin channel were present due to limitations in controlling the yarn bundle internal interactions in the model.
Cooperative musical creation using Kinect, WiiMote, Epoc and microphones: a case study with MinDSounDS

We describe the composition and performance process of the multimodal piece MinDSounDS , highlighting the de-sign decisions regarding the application of diverse sensors, namely the Kinect (motion sensor), real-time audio analysis with Music Information Retrieval (MIR) techniques, WiiMote (accelerometer) and Epoc (Brain-Computer Interface, BCI). These decisions were taken as part of an collaborative creative process, in which the technical restrictions imposed by each sensor were combined with the artistic intentions of the group members. Our mapping schema takes in account the technical limitations of the sensors and, at the same time, respects the performers’ previous repertoire. A deep analysis of the composition process, particularly due to the collaborative aspect, highlights advantages and issues, which can be used as guidelines for future work in a similar condition.
The Effects of Melatonin and Propolis on Markers of In ammation, Oxidative Stress, Clinical Outcomes, and Survival Rate in Patients with Primary Sepsis Hospitalized in Intensive Care Unit: A Randomized Clinical Trial

Naseh Pahlavani Mashhad University of Medical Sciences Alireza Sedaghat Mashhad University of Medical Sciences Gordon A Ferns Brighton and Sussex Medical School Mahdie Mir Razavi Hospital Mahsa Malekahmadi Mashhad University of Medical Sciences Ahmad Bagheri Moghaddam Mashhad University of Medical Sciences Hamed Tabesh Mashhad University of Medical Sciences Omid Sadeghi Tehran University of Medical Sciences Seyedeh Shabnam Mazloumi Kiapey Mashhad University of Medical Sciences Jamshid Gholizadeh Navashenaq Bam University of Medical Sciences Sa eh Firouzi Mashhad University of Medical Sciences Lida Jarahi Mashhad University of Medical Sciences Mohsen Fathi Naja Razi Vaccine and Serum Research Institute Reza Rezvani Mashhad University of Medical Sciences Abdolreza Norouzy Mashhad University of Medical Sciences Maryam Heshmati Mashhad University of Medical Sciences Mohammad Safarian Mashhad University of Medical Sciences Majid Ghayour-Mobarhan (  ghayourm@mums.ac.ir ) Mashhad University of Medical Sciences
The Influence of Green Training on Green Supply Chain Management Practices and Firm’s Performance

This research was conducted to study the influence of green training on green supply chain management (GSCM) and firm’s performance. By using institutional theory to explain the driving force of reducing the impact of environmental processes on the firm. The population of this study are firms that have been certified to ISO 14000 which is an environmentally relevant standard. The research proposes are to study 1) top management support, competitor pressure, and customer pressure that influence on green supply chain management practices; 2) green training that influence on green supply chain management practices; 3) the influence of green supply chain management practices and green training on the firm’s performance. Systematic random was used, Questionnaires were distributed . Structure equation model technique was employed for data analysis. In data analysis by SEM technique, top management support, competitor pressure, customer pressure, and green training play positive effect to the GSCM practices with statistical significant. Furthermore, GSCM practices play positive effect to the firm’s performance with statistical significant. Under the literature foundation, customer pressure, top management support is primary factor to achieve GSCM practices and capabilities for establishment the firm’s performance. To do further on GSCM practices more efficiency, a firm is able to have green training. The literature review also showed that special training must be aligned with improvements in the organizational process. It is evident that green training works through green supply chain management and the relationship between green training is not clear. The results of this study showed that the training did not have correlation to the performance but was related to green supply chain management practices.
Hill at Wilcox-Carrizo Contact in East Texas

A recently discovered buried hill, at least 77 feet high, is composed of strata of the Wilcox group (lower Eocene) and covered on its flanks by cross-bedded sands of the lower Carrizo and at the top by level-bedded shales and silts of the upper Carrizo formation. Peculiar small funnel-shaped pits filled with Carrizo sand extend into the underlying Wilcox ball clay at the peak of the hill. Other extensions fill shrinkage cracks of the clay. These and other features of the contact demonstrate a disconformity at the base of the Carrizo sand caused by rejuvenation that occurred shortly before Carrizo sand deposition.
trans-Golgi Network by Interacting with VACUOLAR SORTING

Running head: 1 A role of AP-4 complex in vacuolar protein sorting 2 3 4 Corresponding Authors: 5 Dr. Tomoo Shimada 6 Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan 7 Tel. : +81 (75) 753-4142; Fax: +81 (75) 753-4142; E-mail: 8 tshimada@gr.bot. kyoto-u.ac. jp 9 Prof. Ikuko Hara-Nishimura 10 Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan 11 Tel. : +81 (75) 753-4142; Fax: +81 (75) 753-4142; E-mail: ihnishi@gr.bot. kyoto-u.ac. jp 12 13 14 Research area: 15 Cell biology 16 17 Plant Physiology Preview. Published on November 6, 2015, as DOI:10.1104/pp.15. 00869
Release of soluble phosphorus through biodegradation of poultry litter by Bacillus

The mineral content of two types of poultry litter; that is from meat producing chickens (broilers) and from egg laying chickens (layers) was investigated. The egg poultry litter was superior to meat poultry litter in the mineral composition, and its mineral content (% DW) was P 3.5, K 3, Ca 9, N 2.4, Mg 0.5, and Fe 1.2 in addition to moderate levels of Mn, Zn, Cu and Mo. The litter content of the toxic heavy metals was small; ranging from 2.6 ppm (mg kg-1) for Cd and 7.4 ppm for Pb to relatively high levels of As (36.3 ppm). The microbial content of egg poultry litter was dense and amounted to 2×106 Colony Forming Unit (CFU) per g dry litter, distributed among twenty four bacterial isolates and seven isolates of actinomycetes; and the bacterial isolates were sorted into twenty-one Gram positive endospore-forming rods and three Gram negative rods. Each of the twenty four bacterial isolates were incubated with sterile egg poultry litter and the release of inorganic phosphorus (Pi) was monitored over time for a period of 20 days. Out of the 24 bacterial isolates three exhibited outstanding ability to release Pi from litter; and from these three isolates, one was selected for further cultural, microscopic and physiological investigations, and was identified as Bacillus subtilis. Upon incubation of Bacillus subtilis with litter the yield of Pi increased progressively with time from an initial value of 0.86 mg Pi g-1 litter to 2.17 mg Pi g-1 litter by the fifteenth day, beyond which it leveled off up to the twentieth day.
A DNA Region Recognized by the Nitric Oxide-Responsive Transcriptional Activator NorR Is Conserved in (cid:2) - and (cid:3) -Proteobacteria

The (cid:1) 54 -dependent regulator NorR activates transcription of target genes in response to nitric oxide (NO) or NO-generating agents. In Ralstonia eutropha H16, NorR activates transcription of the dicistronic norAB operon that encodes NorA, a protein of unknown function, and NorB, a nitric oxide reductase. A constitutively activating NorR derivative (NorR (cid:1) ), in which the N-terminal signaling domain was replaced by MalE, specif-ically bound to the norAB upstream region as revealed by gel retardation analysis. Within a 73-bp DNA segment protected by MalE-NorR (cid:1) in a DNase I footprint assay, three conserved inverted repeats, GGT-(N 7 )-ACC (where N is any base), that we consider to be NorR-binding boxes were identiﬁed. Mutations altering the spacing or the base sequence of these repeats resulted in an 80 to 90% decrease of transcriptional activation by wild- type NorR. Genome database analyses demonstrate that the GT-(N 7 )-AC core of the inverted repeat is found in several proteobacteria upstream of gene loci encoding proteins of nitric oxide metabolism, including nitric oxide reductase (NorB), ﬂavorubredoxin (NorV), NO dioxygenase (Hmp),
Analyzing the Determinants of Export Trade in Cameroon (1970 – 2008)

This research analyses empirically the determinants of export trade in Cameroon from 1970 to 2008. We use the two Stage Least Square to show that exchange rate, trade openness and export lag one period are the main determinants of export in Cameroon. This result, although common in most Developing Countries are in contradiction with former studies, mostly because the foreign direct Investment was found to be not significant in determining the export in this Country. found to be insignificant in causing variations in export volume of Cameroon. The results made us to conclude that some variables (ER, LEXP t-1 , and TO) actually caused variations in Cameroon’s export volume during our period of study, while some did not (FDI, INFLA and IR). From our results, we see that trade openness had a significant positive impact on export trade in Cameroon during our period of study. The low value of the coefficient could be as a result of the country not being effectively economically free. As such, policy reforms aimed at effectively liberalizing trade in Cameroon should be revised. This could make the impact of trade openness to be important in determining export growth in Cameroon. In terms of financial development, trade openness will be a way to obtain money from other countries, in other to invest its surplus in other countries.
INCIDENCE AND OUTCOME OF ACUTE RENAL FAILURE IN NEONATES WITH PERINATAL ASPHYXIA AND ITS CORRELATION WITH APGAR SCORE AND HYPOXIC ISCHEMIC ENCEPHALOPATHY GRADING

consists of ABSTRACT Background: World Health Organization has defined perinatal asphyxia (PNA) as a “failure to initiate and sustain breathing at birth. ” Acute renal failure a recognized complication of birth asphyxia, carries poor immediate prognosis and may result in permanent renal damage in survivors. Objectives: To determine the incidence of Acute Renal Failure in cases of Perinatal Asphyxia and to correlate it with severity of Apgar score and Hypoxic Ischemic Encephalopathy grading. Methods: this study is done on newborns with gestational age >34 weeks having evidence of birth asphyxia based on APGAR scores and renal function assessment done at day 3 of life. Results: among 50 newborns studied, 46 Forty six percent patients had mild PNA where as 42 % patients & 12% patients were having moderate & severe PNA based on APGAR score. ARF was found in 24% cases of PNA with oliguric renal failure (ORF) in 42% and non oliguric renal failure (NORF) in 58% cases. All cases of ARF (100%) had raised blood urea while it was raised only in 8% of non ARF cases. All patients of severe PNA (100%) had ARF whereas only 28% patients of moderate PNA had ARF. None of patients with mild PNA had ARF. Renal USG showed abnormalities in only 2 (4%) asphyxiated newborns. Conclusions: Our results showed a strong relation between severity of PNA and ARF, with no ARF seen in mild PNA.This study showed a linear relationship between incidence of ARF and staging of HIE. Mortality occurred in ORF cases only.