Miracle-dz/UniFAR-FTUs huggingface dataset:
Catheter Ablation to Treat Supraventricular Arrhythmia in Children and Adults With Congenital Heart Disease: What We Know and Where We Are Going.

BACKGROUND Catheter ablation has been used to manage supraventricular arrhythmia in children since 1990. This article reviews the history of catheter ablation used to treat arrhythmia in children and discusses new frontiers in the field. We also address ablation in adult patients with a history of congenital heart disease (CHD) that was diagnosed and initially treated in childhood. METHODS We conducted an evidence-based literature review to gather available data on ablation for supraventricular tachycardia in children and adult patients with CHD. RESULTS Ablations can be performed safely and effectively in children. Complication rates are higher in children <4 years and <15 kg. In one study, the overall success rate of radiofrequency ablation in pediatrics was 95.7%, with the highest success rate in left free wall pathways (97.8%). Recurrence was higher in septal pathways. Cryoablation has been reported to have a 93% acute success rate for atrioventricular (AV) nodal reentrant tachycardia and septal pathways with no risk of AV block and a 5%-9% risk of recurrence. Three-dimensional mapping, intracardiac echocardiography, remote magnetic navigation, and irrigated catheter ablation are new technologies used to treat pediatric and adult patients with CHD. The population of adult patients with CHD is growing, and these patients are at particularly high risk for arrhythmia. A paucity of data is available on ablation in adult patients with CHD. CONCLUSION Electrophysiology for pediatric and adult patients with CHD is a rapidly growing and progressing field. We benefit from continuous development of ablation techniques for adults with structurally normal hearts and have the unique challenge and responsibility to ensure the safe and effective application of these techniques in the vulnerable population of pediatric and adult patients with CHD.
Differential expression of the neuroendocrine genes Hel‐N1 and HuD in small‐cell lung carcinoma: Evidence for down‐regulation of HuD in the variant phenotype

Hel‐N1 and HuD belong to the elav gene family and have gained recent attention as potential neuroendocrine markers for small‐cell lung carcinoma (SCLC). Members of this conserved family normally appear at different stages of neuronal maturation, raising the possibility that their expression patterns in SCLC reflect the degree of neuroendocrine differentiation. I have utilized a ribonuclease protection assay to analyze Hel‐N1 and HuD expression in cultured SCLC cells with high (classic phenotype) and low (variant phenotype) levels of neuroendocrine differentiation. Hel‐N1 was detected in both classic and variant SCLC. Although HuD was detected consistently in classic SCLC, it was low to absent in variant SCLC, indicating a significant down‐regulation in that phenotype. The expression patterns of Hel‐N1 and HuD also were analyzed in 9 primary SCLC and 10 non‐SCLC lung‐tumor samples. In the majority of SCLC samples, either Hel‐N1 or HuD was detected exclusively or predominantly, indicating a pattern of variable gene expression similar to cultured SCLC. Neither transcript could be detected in the non‐SCLC samples. These data indicate that (i) HuD mRNA expression is associated with a higher level of neuroendocrine differentiation in SCLC, (ii) Hel‐N1and HuD expressions are variable in both primary and cultured SCLC and (iii) HuD and Hel‐N1, in combination, are neurogenetic markers for SCLC. Int. J. Cancer 74:378–382, 1997. © 1997 Wiley‐Liss, Inc.
Chiral characterization of deprenyl‐N‐oxide and other deprenyl metabolites by capillary electrophoresis using a dual cyclodextrin system in rat urine

A chiral capillary electrophoresis method has been developed for the simultaneous separation of the enantiomers of deprenyl and eight of its metabolites, among them the recently described metabolite deprenyl‐N‐oxide. Although heptakis‐(2,6‐di‐O‐methyl)‐β‐cyclodextrin (DIMEB) was suitable for the enantioresolution of deprenyl and its dealkylated derivatives, the enantiomers of deprenyl‐N‐oxide were just partly resolved. Carboxymethyl‐β‐cyclodextrin (CMBCD) in as low as 2 mM concentration was capable of the enantiomer separation of all the nine examined compounds, however co‐migration of 1R,2S‐(−)‐norephedrine and 1R,2R‐(−)‐pseudoephedrine, as well as 1S,2R‐(+)‐ephedrine and R‐(−)‐amphetamine was observed. This problem could be overcome by the use of a dual cyclodextrin system containing 4 mM DIMEB in addition to 2 mM CMBCD; simultaneous separation of all the compounds could be achieved. The optimized method was used for the analysis of rat urine samples after 10 days of treatment of animals with either R‐(−)‐ or S‐(+)‐deprenyl. The stereospecific biotransformation of both deprenyl enantiomers was confirmed, and the stereoselectivity of N‐oxide formation was demonstrated.
Screw- versus cement-retained implant prostheses: a systematic review of prosthodontic maintenance and complications.

PURPOSE This systematic review aimed to identify different prosthodontic outcomes between screw- and cement-retained implant prostheses. MATERIALS AND METHODS The relevant articles were retrieved from the following electronic databases: MEDLINE, EMBASE, PubMed (using medical subject headings), and the Cochrane Central Register of Controlled Trials (CENTRAL). The search was performed up to December 31, 2013, and was restricted to studies on human subjects reported in English. A further search was conducted through the reference lists of the articles found as well as from early online articles. Reviewed studies were those on fixed implant prostheses using different retention mechanisms such as screws or cement. Information on types of screws and mechanisms of preloading, as well as different luting cements, was collected in correlation with prosthodontic maintenance/complication issues seen in the clinical studies. RESULTS Sixty-two papers met the review criteria. There were only six randomized controlled trials and none of them included an equivalent number of screw- and cement-retained single implant crowns for comparison. Studies used different types of screws and only a few reported the preloading procedure for the prosthetic screws. Other studies involving cement-retained implant prostheses used a range of dental cements; however, some did not specify the type used. Studies reported various prosthodontic maintenance/complication issues such as screw loosening, porcelain fracture, loss of retention, and esthetic concerns. Five studies did not report any prosthodontic maintenance issues during their observation periods. More recent studies also did not report any incidence of screw loosening. Only two studies stated the standardized criteria for reporting their prosthodontic maintenance/ complication issues. CONCLUSIONS With inadequate information and various study designs, it was difficult to compare the prosthodontic outcomes between screw and cement-retained fixed implant prostheses. Both retention mechanisms showed prosthodontic maintenance/complication issues that must be considered and this review showed that the introduction of newer implant components may assist in minimizing these issues. It is also recommended that standardized criteria be used when reporting prosthodontic maintenance/complication issues to allow better comparison of data.
Maillard Proteomics: Opening New Pages

Protein glycation is a ubiquitous non-enzymatic post-translational modification, formed by reaction of protein amino and guanidino groups with carbonyl compounds, presumably reducing sugars and α-dicarbonyls. Resulting advanced glycation end products (AGEs) represent a highly heterogeneous group of compounds, deleterious in mammals due to their pro-inflammatory effect, and impact in pathogenesis of diabetes mellitus, Alzheimer’s disease and ageing. The body of information on the mechanisms and pathways of AGE formation, acquired during the last decades, clearly indicates a certain site-specificity of glycation. It makes characterization of individual glycation sites a critical pre-requisite for understanding in vivo mechanisms of AGE formation and developing adequate nutritional and therapeutic approaches to reduce it in humans. In this context, proteomics is the methodology of choice to address site-specific molecular changes related to protein glycation. Therefore, here we summarize the methods of Maillard proteomics, specifically focusing on the techniques providing comprehensive structural and quantitative characterization of glycated proteome. Further, we address the novel break-through areas, recently established in the field of Maillard research, i.e., in vitro models based on synthetic peptides, site-based diagnostics of metabolism-related diseases (e.g., diabetes mellitus), proteomics of anti-glycative defense, and dynamics of plant glycated proteome during ageing and response to environmental stress.
Emotion Pancultural Nostalgia : Prototypical Conceptions Across Cultures

Pancultural Nostalgia: Prototypical Conceptions Across Cultures Erica G. Hepper, Tim Wildschut, Constantine Sedikides, Timothy D. Ritchie, Yiu-Fai Yung, Nina Hansen, Georgios Abakoumkin, Gizem Arikan, Sylwia Z. Cisek, Didier B. Demassosso, Jochen E. Gebauer, J. P. Gerber, Roberto González, Takashi Kusumi, Girishwar Misra, Mihaela Rusu, Oisín Ryan, Elena Stephan, Ad J. J. Vingerhoets, and Xinyue Zhou Online First Publication, May 26, 2014. http://dx.doi. org/10.1037/a0036790
Early and Partial Reduction in CD4+Foxp3+ Regulatory T Cells during Colitis-Associated Colon Cancer Induces CD4+ and CD8+ T Cell Activation Inhibiting Tumorigenesis

Colorectal cancer (CRC) is the second most commonly diagnosed cancer in women and the third in men in North America and Europe. CRC is associated with inflammatory responses in which intestinal pathology is caused by different cell populations including a T cell dysregulation that concludes in an imbalance between activated T (Tact) and regulatory T (Treg) cells. Treg cells are CD4+Foxp3+ cells that actively suppress pathological and physiological immune responses, contributing to the maintenance of immune homeostasis. A tumor-promoting function for Treg cells has been suggested in CRC, but the kinetics of Treg cells during CRC development are poorly known. Therefore, using a mouse model of colitis-associated colon cancer (CAC) induced by azoxymethane and dextran sodium sulfate, we observed the dynamic and differential kinetics of Treg cells in blood, spleen and mesenteric lymph nodes (MLNs) as CAC progresses, highlighting a significant reduction in Treg cells in blood and spleen during early CAC development, whereas increasing percentages of Treg cells were detected in late stages in MLNs. Interestingly, when Treg cells were decreased, Tact cells were increased and vice versa. Treg cells from late stages of CAC displayed an activated phenotype by expressing PD1, CD127 and Tim-3, suggesting an increased suppressive capacity. Suppression assays showed that T-CD4+ and T-CD8+ cells were suppressed more efficiently by MLN Treg cells from CAC animals. Finally, an antibody-mediated reduction in Treg cells during early CAC development resulted in a better prognostic value, because animals showed a reduction in tumor progression associated with an increased percentage of activated CD4+CD25+Foxp3- and CD8+CD25+ T cells in MLNs, suggesting that Treg cells suppress T cell activation at early steps during CAC development.
Co-authoring Proto-patterns to Support on Designing Systems to Be Adequate for Users´ Diversity

This paper describes about co-authoring proto-patterns, i.e., patterns candidate, with successful solutions for recurrent problems on generating adequate system that allows users, as co-authors, create, format and make available the content of system according to users ́ profile, language, needs, etc. A case study, considering educational environment, was done in order to collect evidences about the use of these proto-patterns and, it was observed that these proto-patterns express the essence of solutions to support on designing systems to allow co-authoring.
A Probabilistic Mixture Approach to Automatic Ellipse Detection

Ellipse detection from a digital image, especially with a complicated background, is still a very challenging problem in image analysis and understanding, and its difficulty reli es on how to effectively model these ellipses from edge pixels and locate them automatically. In this paper, we propose a probabilist ic mixture model for the probable ellipses in the image and impl ement a Bayesian Ying-Yang (BYY) harmony learning algorithm to learn the parameters of the mixture with automatic model selection so that the correct number of ellipses can be detec t d and located in an automatic way. Various simulation experiments demonstrate better and robust performance by compared with the current state-of-the-art ellipse detection methods. Moreover, it is successfully applied to the elliptical shape detectio n in complex real-world images and the fetal abdominal segmenta ion in ultrasound images.
Neoadjuvant treatment for rectal cancer—A value‐based proposition

Over the last decade, the use of neoadjuvant chemo‐radiation has been an integral part of the care of patients with locally advanced rectal cancer. However, emerging data are beginning to challenge the current treatment paradigm of neoadjuvant chemo‐radiation followed by radical resection and subsequent adjuvant chemotherapy. Going forward, the challenge will be to identify patients for whom radiation can be safely omitted and those for whom it can potentially provide added oncologic value. J. Surg. Oncol. 2016;114:304–310. © 2016 Wiley Periodicals, Inc.
Identification and Phylogenetic Analysis of New Sulfate-Reducing Bacteria Isolated from Oilfield Samples

Microbiologically influenced corrosion (MIC) caused by sulfate-reducing bacteria (SRB) has been investigated in an oilfield injection water system. Strain CW-01 was isolated from an oilfield and strain CW-04 was isolated from biofilm dirt of pipeline walls. The strains were facultative anaerobes, non-motile, Gram-positive, pole flagellum, and spore-forming curved rods. The growth was observed over the temperature range 20-70 °C. Strain CW-01 grew optimally at 37 °C. The pH range for growth was 3.0-11, optimal at pH 6.0. Strain CW-04 grew optimally at 48 °C. The pH range for growth was 3.0-10, optimal at pH 7.2. The strains grew at a very broad range of salt concentrations. Optimal growth was observed with 1.5 g/L NaCl for strain CW-01 and 0.7 g/L NaCl for strain CW-04. The strains showed most similarity in physiological characteristics, except for acetone and saccharose. Analysis of the 16S rDNA sequences allowed strains CW-01 and CW-04 to be classified into the genus Desulfotomaculum. The corrosion speciality of the strains had been comparatively investigated. Especially SRB’s growth curve, bearable oxygen capability, drug fastness and corrosion rate had been analyzed. The results showed that it is difficult to prevent bacterial corrosion caused by these two strains.
Cooperative modulation by eIF 4 G of eIF 4 E-binding to the mRNA 5 cap in yeast involves a site partially shared by p 20

Interaction between the mRNA 5 -cap-binding protein eIF4E and the multiadaptor protein eIF4G has been demonstrated in all eukaryotic translation assemblies examined so far. This study uses immunological, genetic and biochemical methods to map the surface amino acids on eIF4E that contribute to eIF4G binding. Cap-analogue chromatography and surface plasmon resonance (SPR) analyses demonstrate that one class of mutations in these surface regions disrupts eIF4E– eIF4G association, and thereby polysome formation and growth. The residues at these positions in wildtype eIF4E mediate positive cooperativity between the binding of eIF4G to eIF4E and the latter’s cap-affinity. Moreover, two of the mutations confer temperature sensitivity in eIF4G binding to eIF4E which correlates with the formation of large numbers of inactive ribosome 80S couples in vivo and the loss of cellular protein synthesis activity. The yeast 4E-binding protein p20 is estimated by SPR to have a ten times lower binding affinity than eIF4G for eIF4E. Investigation of a second class of eIF4E mutations reveals that p20 shares only part of eIF4G’s binding site on the cap-binding protein. The results presented provide a basis for understanding how cycling of eIF4E and eIF4G occurs in yeast translation and explains how p20 can act as a fine, but not as a coarse, regulator of protein synthesis.
BR1: A New Ultrasonographic Contrast Agent Based on Sulfur Hexafluoride-Filled Microbubbles

RATIONALE AND OBJECTIVESThe basic characteristics of BR1, a novel echo contrast agent based on stabilized sulfur hexafluoride (SF6) microbubbles have been evaluated. METHODSThe authors determined the physicochemical properties (bubble concentration, bubble size distribution, resistance to pressure, and stability) and the acoustic properties (backscatter and attenuation coefficients) of BR1. The diagnostic value of BR1 was evaluated further in minipigs. Left heart images were recorded before and after injection of different doses of BR1. RESULTSBR1 is formulated as a lyophilized product, which after addition of saline, provides a suspension containing 2 × 108 SF6 microbubbles/mL with a number mean diameter of 2.5 µm. More than 90% of the bubbles are below 8 µm. The use of SF6 rather than air provides an improved resistance to pressure increases such as the ones occuring in the left heart during systole. After reconstitution, the echogenicity and the bubble characteristics are unchanged for more than 8 hours. The high echogenicity remains almost constant over the entire medical frequency range ( 1−10 MHz). BR1 injections in animals resulted in a homogenous, dose-dependent opacification of the left heart. CONCLUSIONSConsidering its high echogenicity, outstanding stability, and resistance to pressure changes, BR1 is a very promising ultrasound contrast agent.
Meta-Analysis

This article raises some questions about the usefulness of meta-analysis as a means of reviewing quantitative research in the social sciences. When a meta-analytic model for SAT coaching is used to predict results from future studies, the amount of prediction error is quite large. Interpretations of meta-analytic regressions and quantifications of program and study characteristics are shown to be equivocal. The match between the assumptions of the meta-analytic model and the data from SAT coaching studies is not good, making statistical inferences problematic. Researcher subjectivity is no less problematic in the context of a meta-analysis than in a narrative review.
Measurement system for an in-vitro characterization of the biomechanics and hemodynamics of arterial bifurcations

Arterial behaviour in-vivo is influenced, amongst other factors, by the interaction between blood flow and the arterial wall endothelium, and the biomechanical properties of the arterial wall. This interaction plays an important role in pathogenic mechanisms of cardiovascular diseases such as atherosclerosis and arteriosclerosis. To quantify these interactions both from biomechanical and hemodynamical standpoints, a complete characterization and modelling of the arterial wall, blood flow, shear wall and circumferential wall stresses are needed. The development of a new multi-parameter measurement system (distances, pressures, flows, velocity profiles, temperature, viscosity) for an in-vitro characterization of the biomechanics and hemodynamics in arterial bifurcations (specially in carotid bifurcations) is described. This set-up represents an improvement relative to previous set-ups developed by the group FCIEN-FMED and is presently under development. Main subsystems interactions and environment-system interactions were identified and compensated to improve system's performance. Several interesting problems related with signal acquisition using a variety of sensors and some experimental results are shown and briefly discussed. Experimental data allow construction of meshes and parameter estimation of the biomechanical properties of the arterial wall, as well as boundary conditions, all suitable to be employed in CFD and FSI numerical simulation.
Dynamic biped robot locomotion on less structured surfaces

Most studies in the past on the control of biped locomotion considered only level surfaces. However, in the real world the ground is rarely completely flat. More research on locomotion on less structured surfaces is needed. In this study, we investigated a control design method that searches for suitable control and trajectory parameters using a Genetic Algorithm (GA). Many sets of parameters are generated through the search and the best set is selected based on a robustness measure developed from the linearized Poincaré map. This technique reduces tedious analysis and is favorably applicable to the design for locomotion on unstructured surfaces, for which analytical approaches are less appropriate. Simulations have been performed. Control parameters for different slopes were obtained and stored in a database. During the control, the control parameters suitable for the current surface slope were retrieved and the trajectory for a level surface was modified according to the surface slope. The control parameters changed values according to the terrain. Simulation results were promising.
Unified Classification of Operation-State Regions for Switching Converters with Ramp Compensation

With the variation of circuit parameters, the operation-state regions of current-mode-controlled switching dc-dc converters can shift among stable period region, robust chaos region in continuous conduction mode, and intermittent chaos region in discontinuous conduction mode. This paper presents a unified approach to the operation-states analysis of switching dc-dc converters with ramp compensation. The piecewise map model of the converters is first derived. With the bifurcation analyses, two boundary classification equations of the orbit state shifting are then obtained. Finally, the operation-state regions are well classified. To verify the theoretical analysis results, 2-D bifurcation diagrams are simulated and experimentations with current-mode-controlled buck converter are conducted. It is revealed that regular and irregular (chaotic or intermittent) operation states can be generated depending on circuit parameters or control of ramp-compensation current.
Capacity of a continuous memoryless channel with feedback

Shannon showed that the capacity of a discrete memoryless channel can not be increased by noiseless feedback. It has been conjectured that this should be true for a continuous memoryless channel, provided such a channel is appropriately defined. We precisely define such a channel from two mathematically different points of view and rigorously prove that its capacity can not be increased by feedback.