Miracle-dz/UniFAR-FTUs huggingface dataset:
Feasibility and Acceptability of a Remotely Delivered Weighted Blanket Intervention for People Living With Dementia and Their Family Caregivers

The COVID-19 pandemic amplified the need for interventions to support community-dwelling families living with dementia. This study examined the feasibility and acceptability of a remotely delivered weighted blanket intervention for people living with dementia, and the feasibility of collecting outcome measures specific to people with dementia and caregivers. A prospective, within subjects, pre-post design was used; 21 people with dementia and their caregivers participated. Measures of feasibility (days blanket was used for the recommended duration, injuries/adverse events, enrollment, and withdrawal rate, time to recruit sample) and acceptability (tolerability, satisfaction, and benefit perceived by participants with dementia and caregivers) were examined. Feasibility of collecting measures was examined through missing data. Results indicated high feasibility and acceptability. Collecting caregiver completed outcome measures was feasible, but measures completed by self-report by people with dementia was not. Weighted blankets are a promising tool for this population that warrant further examination to determine efficacy.
Phosphorylated alpha‐synuclein in Iba1‐positive macrophages in the skin of patients with Parkinson's disease

Increasing evidence suggests that alpha‐synuclein (αSyn) accumulation in cholinergic and adrenergic fibers in the skin is a useful biomarker to diagnose idiopathic Parkinson's disease (IPD). It has been widely reported that phosphorylated αSyn (p‐αSyn) deposits in autonomic fibers in IPD are a biomarker in the skin, but other tissue localizations have not been fully investigated.
Effect of platelet‐rich plasma vs standard management for the treatment of diabetic foot ulcer wounds: A meta‐analysis

We performed a meta‐analysis to evaluate the effect of platelet‐rich plasma vs standard management for the treatment of diabetic foot ulcer wounds. A systematic literature search up to March 2022 was performed and 1435 subjects with diabetic foot ulcer wounds at the baseline of the studies; 723 of them were treated with platelet‐rich plasma, and 712 used control. Odds ratio (OR) with 95% confidence intervals (CIs) was calculated to assess the effect of platelet‐rich plasma vs standard management for the treatment of diabetic foot ulcer wounds using the dichotomous method with a random or fixed‐effect model. The use of autologous platelet‐rich plasma resulted in significantly higher complete‐healed diabetic foot ulcer wounds compared with control (OR, 1.95; 95% CI, 1.49‐2.56, P < 0.001). The use of allogeneic platelet‐rich plasma resulted in significantly higher complete‐healed diabetic foot ulcer wounds compared with control (OR, 6.19; 95% CI, 2.32‐16.56, P < 0.001). The use of autologous and allogeneic platelet‐rich plasma resulted in significantly higher complete‐healed diabetic foot ulcer wounds compared with control. Though, the analysis of outcomes should be with caution because of the low number of studies in certain comparisons, for example, allogeneic platelet‐rich plasma compared with control.
Preparing an integrated self-management support intervention for people living with schizophrenia: Creating collaborative spaces.

INTRODUCTION This article describes the planning and development of a novel self-management support protocol, self-management engaging together (SET) for Health, purposefully designed and embedded within traditional case management services to be accessible to people living with schizophrenia and comorbidities. Drawing on established self-management principles, SET for Health was codesigned by researchers, healthcare providers and clients, to create a practical and meaningful intervention to support the target group to manage their own health and wellness. Decision making is described behind tailoring the self-management innovation to meet the needs of an at risk, disadvantaged group served by tertiary, public health care in Canada. METHOD This integrated knowledge translation (IKT) study used a descriptive approach to document the process of planning and operationalizing the SET for Health intervention as a part of routine care in two community-based teams providing predominantly schizophrenia services. Diffusion of innovations literature informed planning. The setting was strategically prepared for organizational change. A situational assessment and theoretical frameworks identified contextual elements to be addressed. Existing established self-management approaches for mental illness were appraised. RESULTS When a review of established approaches revealed incongruence with the aims and context of service delivery, common essential elements were distilled. To facilitate collaborative client-provider self-management conversations and self-management learning opportunities, core components were operationalized by the use of tailored interactive tools. The materials coproduced by clients and providers offered joint reference tools, foundational for capacity-building and recognition of progress. CONCLUSION Planning and developing a model of self-management support for integration into traditional schizophrenia case management services required attention to the complex social ecological nature of the treatment approach and the workplace context. Demonstration of proof of concept is described in a separate paper.
Neonates with acute liver failure have higher overall mortality but similar posttransplant outcomes as older infants

Neonatal acute liver failure (ALF) carries a high mortality rate; however, little data exist on its peritransplant hospital course. This project aimed to identify factors associated with outcomes in neonates with ALF using large multicenter databases. Patients with International Classification of Diseases, Ninth Revision/International Classification of Diseases, Tenth Revision codes for liver failure (2004–2018) from linked Pediatric Health Information System and Scientific Registry of Transplant Recipients databases were assigned to two groups: neonates aged ≤30 days or older infants aged 31–120 days at admission. Billing data were used to assign diagnoses and assess patient comorbidities (sepsis, extracorporeal membrane oxygenation, total parenteral nutrition, intensive care unit, and cardiac/renal/respiratory failure). Statistical analysis included Kaplan–Meier survival curve analysis and univariate and multivariate analyses with the Cox proportional hazards model. We identified 1807 neonates and 890 older infants. Neonates had significantly lower survival to 90 days (p = 0.04) and a lower rate of liver transplantation (2.0% vs. 6.4%; p < 0.001). Common risk factors associated with death or transplant were present between groups: diagnosis, respiratory failure, cardiac failure, and renal failure. Among neonates versus older infants who received a transplant, there was no significant differences in posttransplant lengths of stay (median 38 vs. 32 days; p = 0.53), posttransplant mortality (15% vs. 11%; p = 0.66), or graft loss (9.7% vs. 8.1%; p = 0.82). We present the largest multicenter study on peritransplant outcomes in neonatal ALF and show similar risk factors for death or transplant in neonates compared with older infants. Despite lower transplantation rates, neonates demonstrate similar posttransplant outcomes as older infants. Further studies are needed to better risk stratify neonates eligible for transplant and improve outcomes.
Bayesian clinical reasoning in the first opinion approach to a dog with suspected thoracolumbar pain

Whilst multi‐planar imaging has allowed advances in diagnosis and treatment of canine spinal cord disorders, it is sometimes inaccessible to pet owners leading to a reliance on imaging modalities and ancillary tests that are more readily available. For this reason, this essay considers how Bayesian clinical reasoning may aid in deciding which tests, if any, are most useful for the diagnosis of spinal disease in clinical practice and choosing reasonable empiric therapies.
Quantifying the mass discharge rate of flashing two phase releases through simple holes to the atmosphere

Many toxic industrial chemicals (TICs) such as chlorine and ammonia are stored as liquids at ambient temperature which flash when released to atmospheric pressure. Sponsored by the Chemical Security Analysis Center (CSAC) of the U.S. Department of Homeland Security, the Defense Threat Reduction Agency (DTRA) of the U.S. Department of Defense, and Transport Canada, the Jack Rabbit II tests were designed to release liquid chlorine at ambient temperature in quantities of 4,500–18,000 kg (5 to 20 T) to quantify the hazards of catastrophic release at scales represented by rail and truck transport vessels. All trials were conducted releasing chlorine through a 15.2 cm (6 in) circular breach in the 9,100 kg (10 T) capacity test vessel (disseminator) at different orientations (vertically downward, 45° below horizontal, and vertically up). A final 18,000 kg (20 T) release was made vertically downward using a truck vessel. This article analyzes disseminator load cell data to determine the mass release rate. Along with this data, previously published data are also considered to quantify the impact on release rate of flash fraction and superheat limit temperature for various materials. This work develops a general approach to quantifying the mass release rate of flashing two phase releases of TICs and other flashing liquids such as cryogenics. © 2018 American Institute of Chemical Engineers Process Process Saf Prog 37:382–396, 2018
Understanding the Symptoms and Concerns of Adolescents and Young Adults with Cancer in Alberta: A Comparative Cohort Study Using Patient-Reported Outcomes

Purpose: Adolescents and young adults (AYAs) with cancer are in a unique situation due to their age and developmental stage in life and may have different symptoms and concerns than older patients. Patient-Reported Outcomes (PROs) questionnaires, routinely used in Alberta, can help identify the distinct needs of AYAs. We aimed to compare PROs data for AYAs and older adults (OAs) to better understand how the concerns of AYAs differ, which is key to providing individualized care and creating targeted programming and system-level change. Methods: Retrospective data were collected for two patient cohorts who completed at least one PROs questionnaire between October 1, 2019 and April 1, 2020. The AYA cohort was aged 18–39, and the OA cohort was aged 40 and older. Symptoms were compared using mean scores and multiple linear regression, and concerns were compared using counts and multivariate negative binomial regression. Results: AYAs had significantly higher mean scores on depression and anxiety, compared to OAs, and lower mean scores for most physical symptoms. They indicated significantly more concerns in the Emotional and Social/Family/Spiritual domains, and were over three times more likely to indicate Work/School as a concern. Conclusion: AYAs with cancer have distinct concerns that should be addressed to ensure comprehensive, quality cancer care for this population. PROs data are useful in identifying needs and facilitating evidence-based, data-driven change at all levels of the health care system.
A 3-Fr microcatheter is suitable for a 0.018-inch guidewire during endoscopic ultrasound-guided biliary drainage

A combination of a 22-gauge needle and a 0.018-inch guidewire has become popular for patients with an insufficiently dilated bile duct during endoscopic ultrasound-guided biliary drainage (EUS-BD) [1–3]. However, this combination has several disadvantages, including an insufficient contrast-filled image and limited ability to manipulate the guidewire because of the slimness [1]. Although the catheter must be inserted into the bile duct across the fistula in a challenging situation of this kind, advancing a conventional catheter over a 0.018-inch guidewire can sometimes be difficult because of the gap between the guidewire and the catheter. Here, we report the first use of a new 3-Fr microcatheter that we produced previously [4], which has the following advantages for use with a 0.018-inch guidewire during EUS-BD: (i) it allows easy insertion because of its slimness and flexibility, (ii) it provides a sufficient contrast-filled image, (iii) it assists in manipulating the guidewire to advance into the target space, (iv) it avoids unnecessary dilation until needed, and (v) it allows exchange of the guidewire from 0.018-inch to 0.025-inch to provide support for device insertion (▶Fig. 1). Case 1: A 68-year-old woman, who previously underwent right hepatectomy for hilar cholangiocarcinoma, developed obstructive cholangitis requiring EUSguided hepaticogastrostomy. The advancement of a conventional catheter over the 0.018-inch guidewire failed, whereas the 3-Fr microcatheter was advanced (▶Fig. 2) and a partially covered metal stent successfully deployed. Case 2: A 53-year-old man with obstructive jaundice after subtotal gastrectomy for gastric cancer underwent EUS-guided hepaticojejunostomy. The 0.018-inch guidewire with the 3-Fr microcatheter successfully passed the malignant biliary obstruction (▶Fig. 3); an uncovered metal stent (8 ×60mm) and a plastic stent (7 Fr; 14 cm) were deployed in an antegrade fashion (▶Video 1). E-Videos
Data processing method for constitutive relation of the rubber core material in spherical blowout preventer

A data processing method for constitutive relation of large deformation rubber core in spherical blowout preventer is put forward in this article. Based on the Yeoh constitutive model and the large-deformation theory of rubber material, this article studied the constitutive relation of core material in blowout preventer. The constitutive relation experiments, the uniaxial tensile experiment, the uniaxial compression experiment, the plane tensile experiments, and the volume compression experiment were conducted and the corresponding experiment data were fitted, respectively, on basis of which the uniaxial compression data were selected for further study. For comparison, the data were, respectively, processed with a novel method and the method in GB/7757, and accordingly, two different constitutive relations were obtained and introduced into ABAQUS to simulate the experiment process. Research results show that the relative error of maximum axial deformation between the simulation using GB/7757 and the actual experiment is 34.7%, while that between the novel method and the actual experiment is 20.4%, having improved the accuracy by 14.3%, proving that the data processing method in this article can effectively improve the accuracy of finite element simulation for the core material and will contribute to the research on the performance of spherical blowout preventer.
Emotional Engagement and Caring Relationships: The Assessment of Emotion Regulation Repertoires of Nurses

In spite of the importance of emotion regulation for nurses’ well-being, little is known about which strategies nurses habitually use, how these strategies combine in order to regulate their emotional distress, and how these are related to their caregiving orientations. The current study aimed to explore the emotion regulation repertoires that characterize health-care providers and to investigate the association between these repertoires and caregiving orientations in a sample of nurses. Firstly, a confirmatory factor analyses was run to test the suitability of the Regulation of Emotion System Survey for the assessment of six emotion regulation strategies among health-care providers. Subsequently, the latent profiles analysis was employed to explore emotion regulation repertoires. Three repertoires emerged: The Average, the Suppression Propensity and the Engagement Propensity profiles. The participants of the last two groups relied on Expressive Suppression and Engagement, respectively, more often than others. Nurses were more likely to be placed within the Engagement Propensity group when compared to the first responders, and higher levels of hyperactivation of the Caregiving System were associated with this repertoire. A greater reliance on Expressive Engagement among nurses was discussed in terms of the fact that nurses usually have a longer and more care-oriented relationships with patients than first responders.
Design and performance evaluation of an exponentially weighted moving average–based adaptive control for piezo-driven motion platform

In this article, building a controlled system with velocity feedback in the inner loop for a platform driven by piezoelectric motors is investigated. Such a motion control system is subject to disturbance such as friction, preload, and temperature rise in operation. Especially, temperature rise is an essential problem of using piezoelectric motor, but very few research works address this topic in depth. Exponentially weighted moving average method has been widely used in process control to deal with systematic change and drift disturbance. It is attempted to map the exponentially weighted moving average method and the predictor corrector control with two exponentially weighted moving average formulas into a run-to-run model reference adaptive system for velocity control. Using a predictive friction model, a dead-zone compensator is built that can reduce the friction effect and provide an approximately linear relation of the input voltage and the output velocity for the subsequent exponentially weighted moving average or predictor corrector control control design. Comparison of the exponentially weighted moving average, predictor corrector control, and proportional–integral–derivative controllers is carried out in experiment with different speed patterns on a single-axis and a bi-axial platform. The results indicate that the proposed run-to-run-model reference adaptive system predictor corrector control is superior to the other methods.
Boosting the Cloud Meta-Operating System with Heterogeneous Kernels. A Novel Approach Based on Containers and Microservices

A high SLA is a big challenge for the Cloud providers as they have to ensure the sustainability of their customers’ workloads that depend closely on the undelying OS. The kernels are the cores of the OS, and the monolithic kernels are still the most performant despite of their fragility and unreliability. We think that the superposition of the kernels in such way that a healthy kernel replaces the vulnerable services of another kernel is a good track to operate. This replacement is accomplished via the transfer of system calls from the vulnerable kernel to a more reliable and efficient remote discovered kernel. We propose the architecture of a Meta-OS based on heterogeneous monolithic kernels in order to ensure reliability and performance. The features of this Meta-OS are encapsulated in microservices hosted on containers. Two technologies are used to implement our solution: Virtualization (hardware and OS based) and Web Services.
Mixing and aging of water in distribution system storage facilities

Mixing and aging are two related phenomena that affect the water quality changes that can occur within distribution system storage tanks and reservoirs. Long residence times depress disinfectant residuals and can promote bacterial regrowth, and uneven mixing can result in zones of older water. As a result, minimizing detention time and avoiding zones of water that remain in the storage facility for long periods of time should be implicit objectives in the design and operation of distribution system storage facilities. In this article, the authors present information and tools to assist water utilities in the design, retrofit, or operation of distribution system storage facilities so as to minimize the probability of seriously diminished water quality resulting from poor mixing and excessive aging.
New Spectrum Efficient Reconfigurable Filtered-OFDM Based L-Band Digital Aeronautical Communication System

To meet an ever-increasing demand of the spectrum for aeronautical communication, we propose new L-band digital aeronautical communication system using reconfigurable filtered orthogonal frequency division multiplexing. The proposed protocol enables transceivers to dynamically adapt the transmission bandwidth over a wide range to meet the desired quality of service, and high out-of-band attenuation leads to significant improvement in the vacant spectrum utilization. We support our claims via simulation and complexity comparison results for various realistic channel conditions.
Analytical Solution for 2D Inter-Well Porous Flow in a Rectangular Reservoir

Inter-well fluid flows through porous media are commonly encountered in the production of groundwater, oil, and geothermal energy. In this paper, inter-well porous flow inside a rectangular reservoir is solved based on the complex variable function theory combined with the method of mirror images. In order to derive the solution analytically, the inter-well flow is modeled as a 2D flow in a homogenous and isotropic porous medium. The resulted exact analytical solution takes the form of an infinite series, but it can be truncated to give high accuracy approximation. In terms of nine cases of inter-well porous flow associated with enhanced geothermal systems, the applications of the obtained analytical solution are demonstrated, and the convergence properties of the truncated series are investigated. It is shown that the convergent rate of the truncated series increases with the symmetric level of well distribution inside the reservoir, and the adoption of Euler transform significantly accelerates the convergence of alternating series cases associated with asymmetric well distribution. In principle, the analytical solution proposed in this paper can be applied to other scientific and engineering fields, as long as the involved problem is governed by 2D Laplace equation in a rectangular domain and subject to similar source/sink and boundary conditions, i.e., isolated point sources/sinks and uniform Dirichlet or homogeneous Neumann boundary conditions.
Human gingival mesenchymal stem cells retain their growth and immunomodulatory characteristics independent of donor age

Aging has been reported to deteriorate the quantity and quality of mesenchymal stem cells (MSCs), which affect their therapeutic use in regenerative medicine. A dearth of age-related stem cell research further restricts their clinical applications. The present study explores the possibility of using MSCs derived from human gingival tissues (GMSCs) for studying their ex vivo growth characteristics and differentiation potential with respect to donor age. GMSCs displayed decreased in vitro adipogenesis and in vitro and in vivo osteogenesis with age, but in vitro neurogenesis remained unaffected. An increased expression of p53 and SIRT1 with donor age was correlated to their ability of eliminating tumorigenic events through apoptosis or autophagy, respectively. Irrespective of donor age, GMSCs displayed effective immunoregulation and regenerative potential in a mouse model of LPS-induced acute lung injury. Thus, we suggest the potential of GMSCs for designing cell-based immunomodulatory therapeutic approaches and their further extrapolation for acute inflammatory conditions such as acute respiratory distress syndrome and COVID-19.