Miracle-dz/UniFAR-FTUs huggingface dataset:
Sentinel-2 Image Scene Classification: A Comparison between Sen2Cor and a Machine Learning Approach

Given the continuous increase in the global population, the food manufacturers are advocated to either intensify the use of cropland or expand the farmland, making land cover and land usage dynamics mapping vital in the area of remote sensing. In this regard, identifying and classifying a high-resolution satellite imagery scene is a prime challenge. Several approaches have been proposed either by using static rule-based thresholds (with limitation of diversity) or neural network (with data-dependent limitations). This paper adopts the inductive approach to learning from surface reflectances. A manually labeled Sentinel-2 dataset was used to build a Machine Learning (ML) model for scene classification, distinguishing six classes (Water, Shadow, Cirrus, Cloud, Snow, and Other). This models was accessed and further compared to the European Space Agency (ESA) Sen2Cor package. The proposed ML model presents a Micro-F1 value of 0.84, a considerable improvement when compared to the Sen2Cor corresponding performance of 0.59. Focusing on the problem of optical satellite image scene classification, the main research contributions of this paper are: (a) an extended manually labeled Sentinel-2 database adding surface reflectance values to an existing dataset; (b) an ensemble-based and a Neural-Network-based ML models; (c) an evaluation of model sensitivity, biasness, and diverse ability in classifying multiple classes over different geographic Sentinel-2 imagery, and finally, (d) the benchmarking of the ML approach against the Sen2Cor package.
Core Values of Family Medicine in Europe: Current State and Challenges

Background: Values are deeply held views that act as guiding beliefs for individuals and organizations. They state what is important in a profession. The aims of this study were to determine whether European countries have already developed (or are developing) documents on core values in family medicine; to gather the lists of core values already developed in countries; and to gather the opinions of participants on what the core family values in their countries are. Methods: This was a qualitative study. The questionnaire was distributed as an e-survey via email to present and former members of the European Society for Quality and Safety in Family Practice (EQuiP), and other family medicine experts in Europe. The questionnaire included six items concerning core values in family medicine in the respondent's country: the process of defining core values, present core values, the respondents' suggestions for core values, and current challenges of core values. Results: Core values in family medicine were defined or in a process of being defined in several European countries. The most common core values already defined were the doctor-patient relationship, continuity, comprehensiveness and holistic care, community orientation, and professionalism. Some countries expressed the need for an update of the current core values' list. Most respondents felt the core values of their discipline were challenged in today's world. The main values challenged were continuity, patient-centered care/the doctor-patient relationship and comprehensive and holistic care, but also prioritization, equity, and community orientation and cooperation. These were challenged by digital health, workload/lack of family physicians, fragmentation of care, interdisciplinary care, and societal trends and commercial interests. Conclusion: We managed to identify suggestions for core values of family medicine at the European level. There is a clear need to adopt a definition of a value and tailor the discussion and actions on the family medicine core values accordingly. There is also a need to identify the core values of family medicine in European countries. This could strengthen the profession, promote its development and research, improve education, and help European countries to advocate for the profession.
Association Between Vitamin D Exposure and Head and Neck Cancer: A Systematic Review With Meta-Analysis

Background Vitamin D deficiency is a well-described preventable cause of many cancers; the association of vitamin D use with the development of head and neck cancer (HNC) is not clear. We aim to conduct a systematic review of the studies assessing the relation between vitamin D exposure and the prevention and prognosis of the HNC using meta-analysis. Methods PubMed, EMBASE, Cochrane Library, Web of Science up to 1 January 2021, and reference lists of related studies were searched. We extracted observational studies reporting the association between vitamin D (vitamin D receptor gene polymorphisms, 25-hydroxyvitamin D concentrations, and vitamin D intake) and the outcomes of interest (HNC incidence and HNC mortality) in HNC patients aged 18 or older. Fixed effects models were used to calculate pooled effect sizes and 95% confidence intervals (CIs) by RevMan (version 5.3). Results Sixteen studies with a total of 81,908 participants were enrolled in our meta-analysis. Based on the pooled genomic analysis, comparing with participants with the genotypes of Ff + FF or FF, the pooled odds ratio (OR) of participants with the genotype of ff was 0.77 (95% CI: 0.61 to 0.97) and 0.75 (0.58 to 0.97), respectively. A similar trend was noted when comparing tt with Tt + TT or TT, in which OR (95% CI) was 0.70 (0.55 to 0.90) and 0.72 (0.55 to 0.95). No significant association was identified between BsmI polymorphism and HNC. Furthermore, the OR of HNC incidence was 0.77 (0.65 to 0.92) for participants with vitamin D intake over the ones with a regular diet. High concentrations of circulated 25-hydroxyvitamin D (25-OHD) significantly decreased by 32% of HNC incidence (OR (95% CI): 0.68 (0.59 to 0.78)) and increased HNC survival (pooled hazard ratio 1.13, 1.05 to 1.22) during a 4–5 years follow-up. High concentrations of circulating 25-OHD in patients with HNC led to a decreased risk of mortality to 0.75 (0.60 to 0.94) as the follow-up extends to 8–12 years. Conclusions Elevated activities of vitamin D by diet intake, genomic polymorphisms, or circulated 25-OHD may protect people from HNC and improve the prognosis of patients with HNC. Systematic Review Registration PROSPERO, identifier CRD42020176002 (https://www.crd.york.ac.uk/PROSPERO/display_record.php? RecordID=176002).
Multi-Model Approach on Growth Estimation and Association With Life History Trait for Elasmobranchs

Age and growth information is essential for stock assessment of fish, and growth model selection may influence the accuracy of stock assessment and subsequent fishery management decision making. Previous descriptions of the age and growth of elasmobranchs relied mainly on the von Bertalanffy growth model (VBGM). However, it has been noted that sharks, skates and rays exhibit significant variety in size, shape, and life history traits. Given this variation, the VBGM may not necessarily provide the best fit for all elasmobranchs. This study attempts to improve the growth estimates by using multi-model approach to test four growth models—the VBGM, the two-parameter VBGM, the Robertson (Logistic) and the Gompertz models to fit observed or simulated length-at-age data for 38 species (44 cases) of elasmobranchs. The best-fit growth model was selected based on the bias corrected Akaike’s Information Criterion (AICc), the AICc difference, the AICc weight, the Bayesian Information Criterion (BIC), and the Leave-one-out cross-validation (LOOCV). The VBGM and two-parameter VBGM provide the best fit for species with slow growth and extended longevity (L∞ > 100 cm TL, 0.02 < k < 0.25 yr–1), such as pelagic sharks. For fast-growing small sharks (L∞ < 100 cm TL, kr or kg > 0.2 yr–1) in deep waters and for small-sized demersal skates/rays, the Robertson and the Gompertz models provide the best fit. The best-fit growth models for small sharks in shallow waters are the two-parameter VBGM and the Robertson model. Although it was found that the best-fit growth models for elasmobranchs were associated with their life history trait, exceptions were also noted. Therefore, a multi-model approach incorporating with the best-fit model selected for each group in this study was recommended in growth estimation for elasmobranchs.
The Seismotectonic Significance of Geofluids in Italy

There is growing interest in how geofluid emissions are released in the atmosphere by the planet’s geodynamic activity, and how much they contribute to the global budget of greenhouse gases. Many workers are addressing this issue with studies conducted at global scale, so as to get the required global-scale answers. The data available at the global scale on geofluids, faults, earthquakes and volcanoes, however, are generally too coarse to provide these answers. We investigate the relationships between geofluid emissions and tectonics at a more detailed scale. Building on over a century of data on geofluid emissions and on an extensive knowledge of the region’s tectonics and seismicity, we focused on Italy, one of the areas of the globe that experience the largest release of natural CO2 and CH4. We systematically overlaid and compared data collected by a number of workers into 13 published countrywide databases concerning geofluid emissions, carbon-bearing deposits, seismogenic faults, historical and instrumentally documented earthquakes, and heat flow observations. Our results indicate that 1) thermal springs and CO2 emissions dominate in areas of mantle upwelling and crustal stretching, but also that 2) some of them occur in the extending inner Apennines, generally along major lithospheric chain-perpendicular lineaments that bound the largest normal faults. Conversely, 3) CH4 emissions and mud volcanoes dominate in areas undergoing active contraction, where no CO2 emissions are observed; in particular, we find 4) that mud volcanoes concentrate where the crests of active anticlines intersect major lithospheric chain-perpendicular lineaments. An overarching conclusion is that, in Italy, the release of geofluids is primarily controlled by deep crustal discontinuities that developed over the course of 5–10 My, and is only mildly affected by ongoing crustal strains. Geofluid emissions bring information on processes that occur primarily in the lower crust, marking the surface projection of generally hidden discontinuities that control the geometry and modes of seismic release. As such they may also provide valuable insight for improving the assessment of seismic hazard in hard-to-investigate seismically active regions, such as Italy.
Fitness and Performance Testing of Male and Female Beach Soccer Players—A Preliminary Investigation

Purpose: This study aimed to compare performance on sand and a firm surface and to describe the physical capacity of male and female beach soccer players. Methods: Sixty-six male and 29 female competitive beach soccer players voluntarily participated in this study. Firstly, within-subjects test scores were compared to scores on a firm surface (criterion validity; n = 15 men) and reconducted on a second occasion (reliability; n = 51 men). Secondly, the best score on sand was retained to compare test performance between ages (classified as below 20, 20–30, and above 30 years) and sexes. Performance assessments included sprint time over 5 and 15 m (once on a firm surface and twice on sand), standing long jump (SLJ, once on a firm surface and twice on sand) and Yo-Yo intermittent recovery level 1 (Yo-Yo IR1, once on a firm surface and once on sand; only data for men were available). Results: Five-m sprint and Yo-Yo IR1 performance on sand were not correlated to performance on a firm surface (P > 0.05). Test-retest reliability was acceptable for the 15-m sprint and SLJ tests (ICC > 0.90; CV < 5%). Performance in 15-m sprint and maximal sprinting speed were moderately lower in male players aged above 30 years. compared to players aged below 30 years (d = 0.35–0.42; P < 0.05). Irrespective of the age group, weight-bearing power-based performance mass was moderately to very largely higher in male players than in female players (d = 0.42–0.88; P < 0.05). Conclusions: The lack of a consistent relationship between performance on sand and on a firm surface might indicate the need to develop specific test batteries for sand-based athletes. Age-related differences in physical performance were evident only in sprint capacity. Further studies are warranted to elucidate our preliminary findings and to develop the sand specific tests.
Magnetic Field Induced Changes in the Shoot and Root Proteome of Barley (Hordeum vulgare L.)

The geomagnetic field (GMF) has been present since the beginning of plant evolution. Recently, some researchers have focused their efforts on employing magnetic fields (MFs) higher than GMF to improve the seed germination, growth, and harvest of agriculturally important crop plants, as the use of MFs is an inexpensive and environment-friendly technique. In this study, we have employed different treatments of MF at 7 mT (milliTesla) at different time points of exposure, including 1, 3, and 6 h. The extended exposure was followed by five consecutive days at 6 h per day in barley seeds. The results showed a positive impact of MF on growth characteristics for 5-day-old seedlings, including seed germination rate, root and shoot length, and biomass weight. Furthermore, ~5 days of delay of flowering in pre-treated plants was also observed. We used a shotgun proteomics approach to identify changes in the protein signatures of root and shoot tissues under MF effects. In total, we have identified 2,896 proteins. Thirty-eight proteins in the shoot and 15 proteins in the root showed significant changes under the MF effect. Proteins involved in primary metabolic pathways were increased in contrast to proteins with a metal ion binding function, proteins that contain iron ions in their structure, and proteins involved in electron transfer chain, which were all decreased significantly in the treated tissues. The upregulated proteins' overall biological processes included carbohydrate metabolic process, oxidation-reduction process, and cell redox homeostasis, while down-regulated processes included translation and protein refolding. In general, shoot response was more affected by MF effect than root tissue, leading to the identification of 41 shoot specific proteins. This study provides an initial insight into the proteome regulation response to MF during barley's seedling stage.
Observational Evidence of Distinguishable Weather Patterns for Three Types of Sudden Stratospheric Warming During Northern Winter

Sudden stratospheric warming (SSW) events often lead to a cold surface air temperature anomaly over the extratropical regions. In this study, we propose, through observational evidence, that the types of SSW determine the severity of the cold anomaly. Based on the three-type classification of SSW, it is found that the surface air temperature drops notably over central to eastern North America following an SSW-type transition, especially from displacement to split. Note, however, that the differences in mean surface air temperature anomalies between SSW types are not statistically significant, even though after SSW-type transition from displacement to split, surface air temperature anomalies are colder than the other two types. The development of an anomalous tropospheric ridge in the North Pacific Arctic sector, associated with the difference in the vertical and zonal propagation of planetary waves, characterizes the post-warming period of the displacement–split type. After the occurrence of the displacement–split type transition of SSW events, upward propagation of planetary waves of zonal wavenumber 1 is suppressed, whereas planetary waves of zonal wavenumber 2 increase in the troposphere. Accompanying the ridge in the North Pacific, a trough developed downstream over North America that carries cold polar air therein. The results in this study are relevant for the subseasonal time scale, within 20 days after an SSW occurrence.
What Questions Are on the Minds of STEM Undergraduate Students and How Can They Be Addressed?

Addressing common student questions in introductory STEM courses early in the term is one way that instructors can ensure that their students have all been presented with information about how to succeed in their courses. However, categorizing student questions and identifying evidence-based resources to address student questions takes time, and instructors may not be able to easily collect and respond to student questions at the beginning of every course. To help faculty effectively anticipate and respond to student questions, we 1) administered surveys in multiple STEM courses to identify common student questions, 2) conducted a qualitative analysis to determine categories of student questions (e.g., what are best practices for studying, how can in- and out-of- course time be effectively used), and 3) collaboratively identified advice on how course instructors can answer these questions. Here, we share tips, evidence-based strategies, and resources from faculty that instructors can use to develop their own responses for students. We hope that educators can use these common student questions as a starting point to proactively address questions throughout the course and that the compiled resources will allow instructors to easily find materials that can be considered for their own courses.
Effect of Fragrant Primula Flowers on Physiology and Psychology in Female College Students: An Empirical Study

Indoor plants can positively impact physical and mental health in daily life. However, the benefits of viewing indoor plants may be enhanced if the plants emit a fragrant aroma. In this crossover-design study, we measured the physiological and psychological effects of fragrant and non-fragrant Primula plants on 50 female college students, and explored whether aroma stimulation had additive benefits for this group. Non-fragrant Primula malacoides Franch was used as a control stimulus, and Primula forbesii Franch, which has a floral fragrance, was used as an experimental stimulus. We measured blood pressure, pulse rate, and electroencephalogram (EEG) to evaluate physiological responses, and used a mood state profile and the semantic differential (SD) method to evaluate psychological responses. We found that mean blood pressure and pulse rate decreased significantly after the experiment in both conditions. EEGs showed that the mean values of high alpha waves, high beta waves, and relaxation scores were significantly higher in the experimental vs. control condition. The average scores on each subscale of the psychological questionnaire improved after the experiment in both conditions, and the vitality (V) subscale and total emotional state scores were significantly better in the experimental vs. control condition. The results of the SD method showed that the sense of relaxation and comfort were significantly higher in the experimental vs. control condition. Compared with the non-fragrant Primula, the fragrant Primula induced relatively better physiological and psychological effects.
Social Support and Cognition: A Systematic Review

Although the influence of social support in health is a widely acknowledged factor, there is a significant gap in the understanding of its role on cognition. The purpose of this systematic review was, therefore, to determine the state-of-the-art on the literature testing the association between social support and cognition. Using six databases (WoS, PubMed, ProQuest, PsycINFO, Scopus and EBSCOhost), we identified 22 articles published between 1999 and 2019 involving an empirical quantitative focus which meet the inclusion criteria. Data extraction was performed following PRISMA recommendations. To summarize the extracted data, we used a narrative synthesis approach. Despite limitations, there is overall preliminary evidence of a relevant positive association between social support and cognition. Our results demonstrate there is enough information for an outbreak of experimental research in the area and an expansion of this body of knowledge. We argue that the present evidence lays the foundations for a more comprehensive theoretical model, one that corresponds with the complexity of the topic and possibly considers models derived from social interaction and active inference theories.
Robotics in Spine Surgery: A Technical Overview and Review of Key Concepts

The use of robotic systems to aid in surgical procedures has greatly increased over the past decade. Fields such as general surgery, urology, and gynecology have widely adopted robotic surgery as part of everyday practice. The use of robotic systems in the field of spine surgery has recently begun to be explored. Surgical procedures involving the spine often require fixation via pedicle screw placement, which is a task that may be augmented by the use of robotic technology. There is little margin for error with pedicle screw placement, because screw malposition may lead to serious complications, such as neurologic or vascular injury. Robotic systems must provide a degree of accuracy comparable to that of already-established methods of screw placement, including free-hand, fluoroscopically assisted, and computed tomography–assisted screw placement. In the past several years, reports have cataloged early results that show the robotic systems are associated with equivalent accuracy and decreased radiation exposure compared with other methods of screw placement. However, the literature is still lacking with regard to long-term outcomes with these systems. This report provides a technical overview of robotics in spine surgery based on experience at a single institution using the ExcelsiusGPS (Globus Medical; Audobon, PA, USA) robotic system for pedicle screw fixation. The current state of the field with regard to salient issues in robotics and future directions for robotics in spinal surgery are also discussed.
Interferon Regulatory Factor 4 Regulates the Development of Polymorphonuclear Myeloid-Derived Suppressor Cells Through the Transcription of c-Myc in Cancer

The accumulation of myeloid-derived suppressor cells (MDSCs) is one of the major obstacles to achieve an appropriate anti-tumor immune response and successful tumor immunotherapy. MDSCs in tumor-bearing hosts are primarily polymorphonuclear (PMN-MDSCs). However, the mechanisms regulating the development of MDSCs remain poorly understood. In this report, we showed that interferon regulatory factor 4 (IRF4) plays a key role in the development of PMN-MDSCs, but not monocytic MDSCs. IRF4 deficiency caused a significant elevation of PMN-MDSCs and enhanced the suppressive activity of PMN-MDSCs, increasing tumor growth and metastasis in mice. Mechanistic studies showed that c-Myc was up-regulated by the IRF4 protein. Over-expression of c-Myc almost abrogated the effects of IRF4 deletion on PMN-MDSCs development. Importantly, the IRF4 expression level was negatively correlated with the PMN-MDSCs frequency and tumor development but positively correlated with c-Myc expression in clinical cancer patients. In summary, this study demonstrated that IRF4 represents a novel regulator of PMN-MDSCs development in cancer, which may have predictive value for tumor progression.