Miracle-dz/UniFAR-FTUs huggingface dataset:
Treatment strategies for serotonin reuptake inhibitor-resistant obsessive-compulsive disorder: A network meta-analysis of randomised controlled trials

Abstract Objectives Treatment-resistant obsessive-compulsive disorder is a chronic debilitating illness. We conducted a network meta-analysis [NMA] to compare the efficacy of all interventions in SRI-resistant OCD from published Randomised controlled trials [RCT]. Methods We performed an NMA of RCTs in SRI resistant OCD from all modalities of treatments; pharmacological, psychological, neuromodulation, neurosurgery including deep brain stimulation. The design-by-treatment interaction inconsistency model within the frequentist framework was adopted with a change in Yale-Brown Obsessive-Compulsive Scale score as the primary outcome. We conducted sensitivity analyses excluding studies examining neurosurgical interventions, deep brain stimulation, studies in the paediatric population, and studies from a single geographical region. We also conducted analyses of interventions categorised into treatment groups. Results 55 RCTs examining 19 treatments or placebo involving 2011 participants were included in the NMA. Ondansetron [Standardised mean difference −2.01 (95% CI: −3.19, −0.83)], deep TMS [– 1.95 (−3.25, −0.65)], therapist administered Cognitive Behavioural Therapy [CBT-TA] [−1.46 (−2.93, 0.01)] and aripiprazole [−1.36 (−2.56, −0.17)] were ranked as the best four treatments on using the Surface Under the Cumulative Ranking [SUCRA] percentage values (85.4%, 83.2%, 80.3%, 67.9% respectively). While all four interventions had large effect sizes, CBT[TA] narrowly missed statistical significance in our analysis. In sensitivity analyses, deep TMS was ranked as the best treatment strategy for SRI-resistant OCD. The small number of subjects in individual studies, higher confidence interval limits, and wider prediction interval for most agents warrant a cautious interpretation. Conclusions Considering the principal analysis and sensitivity analyses together, deep TMS, ondansetron, CBT[TA], and aripiprazole may be considered a first-line intervention for SRI-resistant OCD in adults. Other This work was not funded. The NMA has been registered with PROSPERO, [Registration number: CRD42020173589]
The countercyclical long-term operating accrual-based trading strategy in the Stoxx Europe 600 index: The importance of asset and liability components

This work uses long-term operating accruals, rather than current, as an accounting measure to identify major anomalies. Past and abundant accounting and financial literature associates anomalies with problems of reliability and assigns lower reliability to long-term operating accruals than to current accruals. We investigate the relation between scaled operating accruals and size-adjusted abnormal returns for nonfinancial firms listed in the Stoxx Europe 600 index for the period 2000–2021. We find consistent evidence of (1) a higher long-term operating accrual anomaly than working capital accrual, especially, when asset and liability components are separated (2) long-short trading strategies aimed at taking advantage of the anomaly that achieves significant annual returns between 2% and 6% and (3) this trading strategy strongly reduces the risk of stock portfolios during an economic crisis due to its countercyclical nature. These findings have important implications not only for academics, but also for asset managers who want to protect the return of their stock portfolios from high market volatility.
Biallelic variants in ZNF142 lead to a syndromic neurodevelopmental disorder

Biallelic variants of the gene encoding for the zinc‐finger protein 142 (ZNF142) have recently been associated with intellectual disability (ID), speech impairment, seizures, and movement disorders in nine individuals from five families. In this study, we obtained phenotype and genotype information of 26 further individuals from 16 families. Among the 27 different ZNF142 variants identified in the total of 35 individuals only four were missense. Missense variants may give a milder phenotype by changing the local structure of ZF motifs as suggested by protein modeling; but this correlation should be validated in larger cohorts and pathogenicity of the missense variants should be investigated with functional studies. Clinical features of the 35 individuals suggest that biallelic ZNF142 variants lead to a syndromic neurodevelopmental disorder with mild to moderate ID, varying degrees of delay in language and gross motor development, early onset seizures, hypotonia, behavioral features, movement disorders, and facial dysmorphism. The differences in symptom frequencies observed in the unpublished individuals compared to those of published, and recognition of previously underemphasized facial features are likely to be due to the small sizes of the previous cohorts, which underlines the importance of larger cohorts for the phenotype descriptions of rare genetic disorders.
Multiple Genomes of Foot-and-Mouth Disease Virus Serotype Asia-1 Obtained from Subclinically Infected Asian Buffalo (Bubalus bubalis) in Pakistan

We report the near-full-genome sequences of 49 isolates of serotype Asia-1 foot-and-mouth disease virus obtained from subclinically infected Asian buffalo in Islamabad Capital Region, Pakistan, in 2011 to 2012. Sequences from subclinically infected animals are exceedingly rare and complement the more commonly available sequences acquired from clinical cases. ABSTRACT We report the near-full-genome sequences of 49 isolates of serotype Asia-1 foot-and-mouth disease virus obtained from subclinically infected Asian buffalo in Islamabad Capital Region, Pakistan, in 2011 to 2012. Sequences from subclinically infected animals are exceedingly rare and complement the more commonly available sequences acquired from clinical cases.
Impoundment increases methane emissions in Phragmites‐invaded coastal wetlands

Saline tidal wetlands are important sites of carbon sequestration and produce negligible methane (CH4) emissions due to regular inundation with sulfate‐rich seawater. Yet, widespread management of coastal hydrology has restricted tidal exchange in vast areas of coastal wetlands. These ecosystems often undergo impoundment and freshening, which in turn cause vegetation shifts like invasion by Phragmites, that affect ecosystem carbon balance. Understanding controls and scaling of carbon exchange in these understudied ecosystems is critical for informing climate consequences of blue carbon restoration and/or management interventions. Here, we (1) examine how carbon fluxes vary across a salinity gradient (4–25 psu) in impounded and natural, tidally unrestricted Phragmites wetlands using static chambers and (2) probe drivers of carbon fluxes within an impounded coastal wetland using eddy covariance at the Herring River in Wellfleet, MA, United States. Freshening across the salinity gradient led to a 50‐fold increase in CH4 emissions, but effects on carbon dioxide (CO2) were less pronounced with uptake generally enhanced in the fresher, impounded sites. The impounded wetland experienced little variation in water‐table depth or salinity during the growing season and was a strong CO2 sink of −352 g CO2‐C m−2 year−1 offset by CH4 emission of 11.4 g CH4‐C m−2 year−1. Growing season CH4 flux was driven primarily by temperature. Methane flux exhibited a diurnal cycle with a night‐time minimum that was not reflected in opaque chamber measurements. Therefore, we suggest accounting for the diurnal cycle of CH4 in Phragmites, for example by applying a scaling factor developed here of ~0.6 to mid‐day chamber measurements. Taken together, these results suggest that although freshened, impounded wetlands can be strong carbon sinks, enhanced CH4 emission with freshening reduces net radiative balance. Restoration of tidal flow to impounded ecosystems could limit CH4 production and enhance their climate regulating benefits.
Corneal diameter measurements by 3 optical biometers and their effect on phakic intraocular lens sizing

Corneal diameter measurements obtained with 3 optical biometers led to similar percentages (approximately 70%) of eyes with a phakic intraocular lens size equal to the optimal value. Purpose: To compare phakic intraocular lens size calculations based on corneal diameter (CD) measurements by 3 instruments. Setting: G.B. Bietti Foundation I.R. C.C. S. , Rome, Italy. Design: Retrospective interventional case series. Methods: Preoperatively, CD was measured with the Aladdin, IOLMaster 700, and Pentacam AXL Wave. The simulated ICL size was computed by entering CD measurements into the manufacturer's calculator. Postoperatively, vaulting was measured by anterior segment optical coherence tomography. The optimal ICL size (OIS) was calculated and compared with the commercially available OIS (CAOIS). Results: 54 eyes (29 patients) with the implantable collamer lens (ICL) were enrolled. The mean CD was 12.02 ± 0.36 mm with the Aladdin, 12.35 ± 0.39 mm with the IOLMaster 700, and 12.22 ± 0.41 mm with the Pentacam AXL Wave (P < .0001), with the closest agreement between the Pentacam AXL Wave and IOLMaster 700 (95% limits of agreement: −0.43 to +0.17 mm). Vaulting (mean: 558 ± 261 μm) was within 251 and 1000 μm in 49 eyes (83.3%). The mean difference between the simulated ICL size and OIS ranged between −0.11 ± 0.35 mm and 0.10 ± 0.30 mm (P < .0001), with no statistically significant difference between the IOLMaster 700 and Pentacam AXL Wave. The simulated ICL size was equal to CAOIS in 38 eyes (70.37%) with the Aladdin, 37 eyes (68.52%) with the IOLMaster 700, and 39 eyes (72.22%) with the Pentacam AXL Wave, without any statistically significant difference. Conclusions: CD measurements by the 3 devices lead to similar percentages of eyes with an ICL size equal to the OIS. Agreement is closer between the IOLMaster 700 and Pentacam AXL Wave.
Physical and natural cross-linking approaches on 3D gelatin microspheres for cartilage regeneration.

The use of gelatin microspheres (GM) as a cell carrier has been extensively researched. One of its limitation is that it dissolves rapidly in aqueous settings, precluding its use for long-term cell propagation. This circumstance necessitates the use of cross-linking agents to circumvent the constraint. Thus, the current study examines two different methods of cross-linking and their effect on the microsphere's '"physicochemical and cartilage tissue regeneration capacity. Crosslinking was accomplished by physical [Dehydrothermal (DHT)] and natural (Genipin) cross-linking of the 3D gelatin microspheres (GM). We begin by comparing the microstructures of the scaffolds and their long-term resistance to degradation under physiological conditions (in isotonic solution, at 37 °C, pH = 7.4). Infrared spectroscopy indicated that the gelatin structure was preserved after the cross-linking treatments. The cross-linked GM" 'demonstrated good cell adhesion, viability, proliferation, and widespread 3D scaffold colonization when seeded with human bone marrow mesenchymal stem cells (BMSCs). Additionally, the cross-linked microspheres enhanced chondrogenesis, as demonstrated by the data. It was discovered that cross-linked GM increased the expression of cartilage-related genes and the biosynthesis of a glycosaminoglycan-positive matrix as compared to non-crosslinked GM. In comparison, DHT-crosslinked results were significantly enhanced. To summarize, DHT treatment was found to be a superior approach for cross-linking the GM in order to promote better cartilage tissue regeneration.
Implementation of a best‐practice guideline: Early enteral nutrition in a neuroscience intensive care unit

Abstract Current evidence suggests that early enteral nutrition is a best practice and leads to improved clinical outcomes. An evidence‐based practice project was implemented in a busy neurointensive care unit in a midwestern tertiary care facility that was designed to improve care by implementing the early nutrition portion of Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: Society of Critical Care Medicine and the American Society for Enteral and Parenteral Nutrition. The Registered Nurses’ Association of Ontario's (RNAO) Toolkit: Implementation of Best Practice Guidelines (BPGs) was selected and followed to guide implementation and achieve optimal results. During a 90‐day implementation period, this project resulted in a 100% improvement in early nutrition. Interventions included the use of a series of cards that reminded the team to order enteral nutrition and prepacked bundles of nasogastric tube supplies. The RNAO toolkit served as a structured and effective step‐by‐step methodology for the implementation of a BPG.
MMNet: A Model-Based Multimodal Network for Human Action Recognition in RGB-D Videos

Human action recognition (HAR) in RGB-D videos has been widely investigated since the release of affordable depth sensors. Currently, unimodal approaches (e.g., skeleton-based and RGB video-based) have realized substantial improvements with increasingly larger datasets. However, multimodal methods specifically with model-level fusion have seldom been investigated. In this article, we propose a model-based multimodal network (MMNet) that fuses skeleton and RGB modalities via a model-based approach. The objective of our method is to improve ensemble recognition accuracy by effectively applying mutually complementary information from different data modalities. For the model-based fusion scheme, we use a spatiotemporal graph convolution network for the skeleton modality to learn attention weights that will be transferred to the network of the RGB modality. Extensive experiments are conducted on five benchmark datasets: NTU RGB+D 60, NTU RGB+D 120, PKU-MMD, Northwestern-UCLA Multiview, and Toyota Smarthome. Upon aggregating the results of multiple modalities, our method is found to outperform state-of-the-art approaches on six evaluation protocols of the five datasets; thus, the proposed MMNet can effectively capture mutually complementary features in different RGB-D video modalities and provide more discriminative features for HAR. We also tested our MMNet on an RGB video dataset Kinetics 400 that contains more outdoor actions, which shows consistent results with those of RGB-D video datasets.
RELIABILITY STUDY OF AlTi / TiW ON POLYSILICON CONTACT RESISTANCE FOR HIGH TEMPERATURE MEMS APPLICATIONS

ABSTRACT This paper deals with the reliability of metal on polysilicon gauges for sensors operating in harsh environments. Particular test structures and characterization equipment have been developed in order to study the contact resistance behavior and long term stability of AlTi / TiW on polysilicon after extended exposure at 150°C. Finite Element Modeling (FEM) of current density distribution over the test structures allowed accurate contact resistance extraction. Fig.1. Schematic cross-section and equivalent electrical circuit for a PSOI contact Keywords: test structure, contact, TiW, FEM, reliability The main purpose of the present work was to verify the long stability at high temperatures of AlTi on polysilicon contacts using a TiW diffusion barrier. The choice of this diffusion barrier was motivated by the simplicity of the process which does not involve reactive sputtering as for TiN films. The TiW target contained 10% Ti by weight (equivalent to Ti 0.3 W 0.7 atomic composition) in order to improve W adhesion and oxidation resistance [2].
Essays on Electric Vehicle Adoption

As a part of the initiative to improve the local air quality, cities encourage fleets of vehicles to adopt alternative technologies like electric vehicles. Motivated by the above, we study an environment consisting of a Taxi Cab company (TC) and an ElectricVehicle Infrastructure Service Provider (SP). The TC has a fleet of taxicabs and must make a fleet renewal decision with some combination of electric vehicles (EVs) and internal combustion engine vehicles (ICEs). The SP has a network of battery swapping stations and offers infrastructure services such as swapping and recharging for a fee.The SP has to decide whether to invest in battery swapping stations for TC along with planning for EVs in terms of the number of batteries stocked at the swapping stations. First, in a centralized setting, we combine SP and TC into a single vertically-integrated entity and analyze factors that influence EV adoption such as the average miles driven by vehicles, the associated uncertainty in miles driven, the diversity in miles driven by different vehicles, and varied cost parameters. Second, in a decentralized setting, we treat SP and TC as individual entities. We examine the SP’s problem of pricing infrastructure services to TCs and identify strategies for the SP to maximize profits. Third, we integrate emissions control policies into the decision-making process and study their impact on the coordination of adoption decisions. Overall, we identify several managerial insights on EV adoption using multiple perspectives: vertical integration of entities, decentralized and emissions.
Beyond the defensible threshold : the house-building culture of Berwick-upon-Tweed and the East March, 1550-1603

The thesis questions the assumption that housebuilding in England’s far north was limited by a need for defensibility until after the Union of the English and Scottish Crowns in 1603. Only a few houses survive to provide evidence but the concept of a ‘house-building culture’ enables an interdisciplinary approach to the subject, using historical, architectural and archaeological evidence originating in the culture within which houses were conceived, constructed and altered. A proposed model for the house-building culture also structures the thesis. Chapters 3-6 examine some individual elements. The character of pre-existing houses suggests what builders might have expected from a house, while alterations indicate a desire for more rooms with specific functions, wider stairs and new chimneys, hallmarks of Hoskins’ ‘Great Rebuilding’. Changing tenure encouraged higher-quality housebuilding, and urban plots provide evidence of Johnson’s ‘closure’. The ‘builders’ who instigated particular house-building or alteration projects, and their motives for building, are examined, as are the craftsmen and artisans and their materials, and finally the communication between builders and craftsmen within the construction process. Chapters 7 and 8 provide six ‘building biographies’ which show this house-building culture at work in various situations. They demonstrate how the culture can form a useful lens with which to view houses which no longer exist or about which little is known, as well as to expand understanding of those apparently better understood. Overall, the study indicates that Berwick and the East March were involved in national trends such as ‘rebuilding’ or ‘closure’, albeit in a locally-defined way. Defence was by no means its primary driver or defining characteristic, although the presence of a previously unrecognised non-domestic type of military ‘stronghouse’ is suggested.
Structure, function and druggability of the African trypanosome flagellum

African trypanosomes are early branching protists that cause human and animal diseases, termed trypanosomiases. They have been under intensive study for more than 100 years and have contributed significantly to our understanding of eukaryotic biology. The combination of conserved and parasite‐specific features mean that their flagellum has gained particular attention. Here, we discuss the different structural features of the flagellum and their role in transmission and virulence. We highlight the possibilities of targeting flagellar function to cure trypanosome infections and help in the fight to eliminate trypanosomiases.
Effect of feeding of sorghum stover based complete feed blocks containing guar meal as protein supplement on reproductive efficiency, hormone profile and antioxidant status in Deccani ewes

Guar meal (GM) can be considered as an alternative protein source for the livestock and has a potential value as a feed to animals with a high protein content ranging between 45–55%. A study was conducted to evaluate the effect of partial replacement of groundnut cake (GNC) with guar meal (GM) on reproductive efficiency, hormone profile, antioxidant status in Deccani ewes fed sorghum stover based complete feed blocks (SSCFB). Twenty-one non-pregnant Deccani ewes (b. wt. 23.34 ±0.40 kg; 2–4 years old and body condition score 2.51±0.56) were randomly divided into three groups to contain 7 animals each in a completely randomized design. Three dietary treatments viz. S1: conventional feeding (sorghum stover and concentrate mixture fed separately in 50:50 ratios to meet the requirement), S2: SSCFB with GNC as protein supplement in concentrate mixture and S3: SSCFB with GM replacing GNC nitrogen of S2 at 50% level. The ewes were synchronised for estrus with progesterone impregnated intravaginal sponges and naturally mated. The ewes were fed at the rate of 3.1 and 3.7% of their body weight from 1st day of experiment—to 108th day of gestation and from 108th day of gestation to till lambing, respectively. The replacement of 50% of GNC nitrogen with GM and densification of diet had no effect (P>0.05) on average DMI (g), antioxidant status, progesterone concentration, conception rate, non return rate, no of matings per service, lambing rate, body weights of lambs at birth, 15 and 30 days of age. GNC can be partially replaced by GM in the ewes diet without any adverse effect on reproductive parameters, antioxidant status, progesterone concentration and weight of lambs.
Genomic characterization and expression analysis of TCP transcription factors in Setaria italica and Setaria viridis

ABSTRACT The plant-specific TCP transcription factor plays important roles in plant development and environment adaptation. Setaria italica and Setaria viridis, the C4 model plants, can grow on drought or arid soils. However, there is no systematic information about the genomic dissection and the expression of Setaria TCP genes. A total of 22 TCP genes were both identified from S. italica and S. viridis genomes. They all contained bHLH domain and were grouped into three main clades (PCF, CIN, and CYC/TB1). The TCP genes in the same clades shared similar gene structures. Cis-element in the TCP promoter regions were analyzed and associated with hormones and stress responsiveness. Ten TCP genes were predicted to be targets of miRNA319. Moreover, gene ontology analysis indicated three SiTCP and three SvTCP genes were involved in the regulation of shoot development, and SiTCP16/SvTCP16 were clustered together with tillering controlling gene TB1. The TCP genes were differentially expressed in the organs, but SiTCP/SvTCP orthologs shared similar expression patterns. Ten SiTCP members were downregulated under drought or salinity stresses, indicating they may play regulatory roles in abiotic stresses. The study provides detailed information regarding Setaria TCP genes, providing the theoretical basis for agricultural applications.