Miracle-dz/UniFAR-FTUs huggingface dataset:
Data security issues in cloud-based Software-as-a-Service ERP

This paper discusses the data security issues and concerns that are prevalent when organizations are moving their Enterprise Resource Planning (ERP) systems to the cloud. Cloud computing has reinvented how organizations conduct business and has enabled them to innovate and compete in a dynamic environment through new and innovative business models. The growing popularity and success of the cloud has led to the emergence of cloud-based Software-as-a-Service (SaaS) ERP systems, a new alternative approach to traditional on-premise ERP systems. Cloud-based ERP has a myriad of benefits for organizations. However, infrastructure engineers need to address data security issues before moving their enterprise applications to the cloud. Cloud-based ERP raises specific concerns about the confidentiality and integrity of the data stored in the cloud. Such concerns that affect the adoption of cloud-based ERP are based on the size of the organization. Small to medium enterprises (SMEs) gain the maximum benefits from cloud-based ERP as many of the concerns around data security are not relevant to them. On the contrary, larger organizations are more cautious in moving their mission critical enterprise applications to the cloud. A hybrid solution where organizations can choose to keep their sensitive applications on-premise while leveraging the benefits of the cloud is proposed in this paper as an effective solution that is gaining momentum and popularity for large organizations.
Determining synthesis rates of individual proteins in zebrafish (Danio rerio) with low levels of a stable isotope labelled amino acid

The zebrafish is a powerful model organism for the analysis of human cardiovascular development and disease. Understanding these processes at the protein level not only requires changes in protein concentration to be determined but also the rate at which these changes occur on a protein‐by‐protein basis. The ability to measure protein synthesis and degradation rates on a proteome‐wide scale, using stable isotope labelling in conjunction with mass spectrometry is now a well‐established experimental approach. With the advent of more selective and sensitive mass spectrometers, it is possible to accurately measure lower levels of stable isotope incorporation, even when sample is limited. In order to challenge the sensitivity of this approach, we successfully determined the synthesis rates of over 600 proteins from the cardiac muscle of the zebrafish using a diet where either 30% or 50% of the L‐leucine was replaced with a stable isotope labelled analogue ([2H7]L‐leucine]. It was possible to extract sufficient protein from individual zebrafish hearts to determine the incorporation rate of the label into hundreds of proteins simultaneously, with the two labelling regimens showing a good correlation of synthesis rates.
Monitoring and estimating tropical forest carbon stocks: making REDD a reality

Reducing carbon emissions from deforestation and degradation in developing countries is of central importance in efforts to combat climate change. Key scientific challenges must be addressed to prevent any policy roadblocks. Foremost among the challenges is quantifying nations’ carbon emissions from deforestation and forest degradation, which requires information on forest clearing and carbon storage. Here we review a range of methods available to estimate national-level forest carbon stocks in developing countries. While there are no practical methods to directly measure all forest carbon stocks across a country, both ground-based and remote-sensing measurements of forest attributes can be converted into estimates of national carbon stocks using allometric relationships. Here we synthesize, map and update prominent forest biomass carbon databases to create the first complete set of national-level forest carbon stock estimates. These forest carbon estimates expand on the default values recommended by the Intergovernmental Panel on Climate Change’s National Greenhouse Gas Inventory Guidelines and provide a range of globally consistent estimates.
Continuing Education Course: Tissue-Based Image Analysis Meeting Report: Tissue-based Image Analysis

Quantitative image analysis (IA) is a rapidly evolving area of digital pathology. Although not a new concept, the quantification of histological features on photomicrographs used to be cumbersome, resource-intensive, and limited to specialists and specialized laboratories. Recent technological advances like highly efficient automated whole slide digitizer (scanner) systems, innovative IA platforms, and the emergence of pathologist-friendly image annotation and analysis systems mean that quantification of features on histological digital images will become increasingly prominent in pathologists’ daily professional lives. The added value of quantitative IA in pathology includes confirmation of equivocal findings noted by a pathologist, increasing the sensitivity of feature detection, quantification of signal intensity, and improving efficiency. There is no denying that quantitative IA is part of the future of pathology; however, there are also several potential pitfalls when trying to estimate volumetric features from limited 2-dimensional sections. This continuing education session on quantitative IA offered a broad overview of the field; a hands-on toxicologic pathologist experience with IA principles, tools, and workflows; a discussion on how to apply basic stereology principles in order to minimize bias in IA; and finally, a reflection on the future of IA in the toxicologic pathology field.
Controlled synthesis and chemical conversions of FeO nanoparticles.

Transition metal oxide nanoparticles of type MO, where M is Mn, Co, Ni, or Fe, have attracted tremendous interest recently because of their potential as electrode materials for recharge-able solid-state batteries, [1] as efficient catalysts for fuel-cell reactions, [2] and as nanoscale magnetic models for under-standing nanomagnetism. [3] W&stite (FeO) is one form of the common iron oxides, a group that also includes hematite ( a - Fe 2 O 3 ), maghemite ( g -Fe 2 O 3 ), and magnetite (Fe 3 O 4 ). It has a rock-salt structure with Fe and O forming nonstoichiometric Fe x O ( x = 0.83–0.96) and Fe vacancies in an ordered distri-bution. [4] The structure is not chemically stable and is prone to decomposition into a -Fe and inverse spinel Fe 3 O 4 through a two-step disproportionation process or to oxidation to form Fe 3 O 4 , g -Fe 2 O 3 , and/or a -Fe 2 O 3 . [4] This chemical reactivity makes FeO nanoparticles difficult to make and those prepared from the high-temperature solution-phase decomposition of iron salt have not been fully characterized. [5] Herein we report a facile organic-phase synthesis of monodisperse FeO nanoparticles through high-temperature reductive decomposition of iron(III) acetylacetonate ([Fe-(acac) 3 ]) with oleic acid (OA) and oleylamine (OAm) both as surfactants and solvents. The sizes of the particles are tuned from 14 to 100 nm by controlling the heating conditions and the shapes of the particles are controlled to be either spherical or truncated octahedral depending on the volume ratio of OA and OAm used in the reaction. Thermal annealing under an
Effect of Sucrose and Glucose Concentrations on Micro- propagation of Musa sp.cv. Grand Naine

This study was carried out at the tissue culture laboratory of Sudan University of Science and Technology during the period from April to June 2009 for study the effect of sugar concentrations (sucrose and glucose) on micropropagation of Musa in vitro the concentrations of sucrose were used is 0(control) , 15, 30, 45, 60 and 75g/l sucrose. And the concentrations of glucose were used is 30g/l sucrose (control) ,15, 30, 45, 60 and75g/l glucose. Ten replicates were used for each treatment. Results indicated that the 30g/l and 45g/l sucrose and 45g/l and 60g/l glucose show significant increase in micro-propagation of Musa. Index term: Musa species, Glucose, Sucrose, Propagation
Molecular characterization of Babesia and Cytauxzoon species in wild South-African meerkats

SUMMARY Piroplasms, including Babesia, Cytauxzoon and Theileria species, frequently infect domestic and wild mammals. At present, there is no information on the occurrence and molecular identity of these tick-borne blood parasites in the meerkat, one of South Africa's most endearing wildlife celebrities. Meerkats live in territorial groups, which may occur on ranchland in close proximity to humans, pets and livestock. Blood collected from 46 healthy meerkats living in the South-African Kalahari desert was screened by microscopy and molecular methods, using PCR and DNA sequencing of 18S rRNA and ITS1 genes. We found that meerkats were infected by 2 species: one species related to Babesia sp. and one species related to Cytauxzoon sp. Ninety one percent of the meerkats were infected by the Cytauxzoon and/or the Babesia species. Co-infection occurred in 46% of meerkats. The pathogenicity and vectors of these two piroplasm species remains to be determined.
Retrograde Drilling for Osteochondral Lesions of the Talar Dome

Background For the treatment of osteochondral lesions of the talar dome without detachment of the cartilage, there is little information on whether transmalleolar drilling or retrograde drilling is more effective in terms of clinical and morphologic evaluations. Hypothesis Retrograde drilling may be more effective than transmalleolar drilling for lesions without cartilage detachment. Study Design Case control study; Level of evidence, 3. Methods Subjects were 30 patients with lesions on 1 foot of grade 0 or I, determined according to a modified Pritsch classification system. Nineteen patients underwent transmalleolar drilling (TMD group), and 11 patients underwent retrograde drilling (RD group). Ankle arthroscopy was performed 1 year postoperatively to evaluate cartilage conditions. Results Arthroscopic findings revealed that in the TMD group, 11 lesions (57.9%) were unchanged (grade I), and 8 lesions (42.1%) had deteriorated from grade 0 to I; in the RD group, 3 lesions (27.2%) had improved from grade I to 0, and 8 (72.8%) were unchanged (2 grade 0 lesions and 6 grade I lesions). There was a significant difference between the 2 groups in the distribution of cases that had improved, were unchanged, or had deteriorated (P < .0001). Conclusions This study showed that compared with transmalleolar drilling, retrograde drilling for osteochondral lesions of the talar dome can improve the arthroscopic assessment of the lesions.
Pubertal development and sedentary behaviour during adolescence

Background: Assessing time spent in sedentary behaviours in relation to pubertal status, anthropometric differences, and body image will improve insight into the prevalence and determinants of such behaviours during adolescence. Aim: The study aimed to investigate the effects of age, puberty, gender, body composition, and sleep on sedentary behaviour. Participants and methods: Participants were 64 boys and 55 girls in Year 6 (10.0–10.9 years of age), Year 8 (12.0–12.9 years) and Year 10 (14.0–14.9 years). Body mass index and percentage body fat were calculated from anthropometric measures. Sedentary behaviour and sleep time were computed using momentary-time sampling. Body image was measured using the Children's Physical Self-Perception Profile. Pubertal status was assessed from self-report of secondary sexual characteristics. Results: After controlling for sleep time, no differences in sedentary time were seen for puberty onset or increased pubertal development. Correlations between pubertal status, body composition, and body image were stronger in girls than in boys. Correlations between body image and sedentary behaviour were not strong enough to infer behavioural choice differences. Conclusions: Reduced sleep time rather than changing body image and body composition during adolescence is associated with greater sedentary behaviour.
Universal Programmability - How AI Can Help

Everyone should be able to program. Programming in informal, but precise natural language would enable anyone to program and help eliminate the world-wide software backlog. Highly trained software engineers would still be needed for complex and demanding applications, but not for routine programming tasks. Programming in natural language is a monumental challenge and will require AI and software researchers to join forces. Early results, however, appear promising. Combining natural language understanding and ontological reasoning helps remove defects from requirements statements, transforms requirements into UML models, and might even enable script-like programming in specific, narrow domains. An important precondition for rapid progress in this area are benchmarks that help compare different approaches and stimulate competition among researchers.
Rehabilitation priorities for individuals with Prader-Willi Syndrome

Purpose. To identify rehabilitation priorities that parents have for their children, including their adult-aged children, with Prader-Willi Syndrome (PWS) and to determine the relation between these priorities and the child's levels of adaptive behaviour functioning. Methods. Parents involved in organisations related to PWS were invited to complete an online survey. The survey listed 54 skills/behaviours (e.g. toileting, expresses wants and needs and tantrums) representing 10 adaptive functioning domains (e.g. self-care, communication and problem behaviour). Parents rated their child's current level of ability/performance with respect to each skill/behaviour and indicated the extent to which training/treatment was a priority. Results. Fifty-eight surveys were completed during the 4-month data collection period. Parents identified nine high-priority skills/behaviours from five different adaptive functioning domains. For most domains, parent priorities showed a significant linear relation to the children's adaptive behaviour deficits, in that priorities reflected areas where the child had the greatest deficits and the most problematic behaviours. Conclusion. Rehabilitation professionals should focus on the eating issues that arise in PWS and identify the adaptive functioning deficits of these individuals because such deficits are high-priority areas for parents.
358,534 nonwords: The ARC Nonword Database

The authors present a model of the phonotactic and orthographic constraints of Australian and Standard Southern British English monosyllables. This model is used as the basis for a web-based psycholinguistic resource, the ARC Nonword Database, which contains 358,534 monosyllabic nonwords—48,534 pseudohomophones and 310,000 non-pseudohomophonic nonwords. Items can be selected from the ARC Nonword Database on the basis of a wide variety of properties known or suspected to be of theoretical importance for the investigation of reading.
Successful Organ Transplantation from Donors with Acinetobacter Baumannii Septic Shock

Donor bacteremia with severe sepsis, especially due to gram-negative organisms, has been considered a contraindication to transplantation. Over a 6-month period we prospectively collected standardized data on all brain-dead, heart-beating organ donors with gram negative bacteremia and septic shock and the recipients of their organs in hospitals throughout Israel. Donors were treated with appropriate antibiotics for at least 48 hr prior to organ retrieval while recipients received 7 days of culture-specific antibiotics following transplantation. In total, 12 organs were transplanted (5 kidneys, 2 livers, 3 lungs and 2 hearts) from 3 donors with Acinetobacter baumannii bacteremia and septic shock. All patients were alive with good graft function 60 days following transplantation, apart from one of the heart recipients who died of primary nonfunction on the second postoperative day. Two recipients developed postoperative infections, none with Acinetobacter sp. (one Pseudomonas sp. urinary tract infection, one Klebsiella sp. central venous catheter sepsis).
Different Domains of Mammalian ADP-ribosylation Factor 1 Mediate Interaction with Selected Target Proteins*

Mammalian ADP-ribosylation factor 1 (mARF1) is a small GTP-binding protein that is activated by a Golgi guanine nucleotide exchange factor. Once bound to the Golgi membranes in the GTP form, mARF1 initiates the recruitment of the adaptor protein 1 (AP-1) complex and coatomer (COPI) onto these membranes and activates phospholipase D1 (PLD1). To map the domains of mARF1 that are important for these activities, we constructed chimeras between mARF1 andSaccharomyces cerevisiae ARF2, which functions poorly in all of these processes except COPI recruitment. The carboxyl half of mARF1 (amino acids 95–181) was essential for activation by the Golgi guanine nucleotide exchange factor, whereas a separate domain (residues 35–94) was required to effectively activate PLD1 and to promote efficient AP-1 recruitment. Since residues 35–94 of mARF1 are critical for optimal activity in both PLD1 activation and AP-1 recruitment, we hypothesize that this region of ARF contains residues that interact with effector molecules.
The Structure of a Mutant Insulin Uncouples Receptor Binding from Protein Allostery

The zinc insulin hexamer undergoes allosteric reorganization among three conformational states, designated T6, \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathrm{T}_{3}\mathrm{R}_{3}^{\mathrm{f}}\) \end{document}, and R6. Although the free monomer in solution (the active species) resembles the classical T-state, an R-like conformational change is proposed to occur upon receptor binding. Here, we distinguish between the conformational requirements of receptor binding and the crystallographic TR transition by design of an active variant refractory to such reorganization. Our strategy exploits the contrasting environments of HisB5 in wild-type structures: on the T6 surface but within an intersubunit crevice in R-containing hexamers. The TR transition is associated with a marked reduction in HisB5 pKa, in turn predicting that a positive charge at this site would destabilize the R-specific crevice. Remarkably, substitution of HisB5 (conserved among eutherian mammals) by Arg (occasionally observed among other vertebrates) blocks the TR transition, as probed in solution by optical spectroscopy. Similarly, crystallization of ArgB5-insulin in the presence of phenol (ordinarily a potent inducer of the TR transition) yields T6 hexamers rather than R6 as obtained in control studies of wild-type insulin. The variant structure, determined at a resolution of 1.3Å, closely resembles the wild-type T6 hexamer. Whereas ArgB5 is exposed on the protein surface, its side chain participates in a solvent-stabilized network of contacts similar to those involving HisB5 in wild-type T-states. The substantial receptor-binding activity of ArgB5-insulin (40% relative to wild type) demonstrates that the function of an insulin monomer can be uncoupled from its allosteric reorganization within zinc-stabilized hexamers.
Sociocultural significance of the endangered Hawaiian monk seal and the human dimensions of conservation planning

The Hawaiian monk seal Monachus schauinslandi is Critically Endangered, but rel- atively little is known about the sociocultural significance of the species in Native Hawaiian com- munities. An accurate assessment of historical and modern sociocultural values and perceptions is needed to inform conservation and recovery planning for the species, particularly since the spe- cies is not universally well-regarded by ocean users. We conducted extensive archival research and oral history interviews to characterize past and current humanmonk seal relationships in the Hawaiian archipelago. We report heterogeneity in both historical and contemporary cultural asso- ciations for monk seals, which appear to be related to place-specific histories and specific stake- holder groups. We introduce the concept of 'cultural endemism' to characterize this pattern of sociocultural heterogeneity, and discuss the relevance of shifting baselines, species recovery, and sociocultural information to conservation planning. We focus on participatory conservation plan- ning approaches as being potentially useful in reducing humanwildlife conflicts and developing collaborative stewardship for better conservation success.
Uma Ontologia de Requisitos de Software

Tool integration in Software Development Environments (SDEs) is a complex problem. A way to improve tool integration is building them sharing a common conceptualization, given by ontologies. This paper presents a software requirements ontology developed to serve as basis for the development of tools to support the requirements engineering process in the SDE ODE (Ontologybased software Development Environment). Since in the context of ODE’s Project several software engineering domain ontologies were developed, the software requirements ontology was built integrated to them, reusing conceptualizations previously established.
PKB‐mediated negative feedback tightly regulates mitogenic signalling via Gab2

Heregulin (HRG)‐induced tyrosine phosphorylation of the Gab2 docking protein was enhanced by pretreatment with wortmannin, indicating negative regulation via a PI3‐kinase‐dependent pathway. This represents phosphorylation by the serine/threonine kinase protein kinase B (PKB), since PKB constitutively associates with Gab2, phosphorylates Gab2 on a consensus phosphorylation site, Ser159, in vitro and inhibits Gab2 tyrosine phosphorylation. However, expression of Gab2 mutated at this site (S159A Gab2) not only enhanced HRG‐induced Gab2 tyrosine phosphorylation and association with Shc and ErbB2, but also markedly increased tyrosine phosphorylation of ErbB2 and other cellular proteins and amplified activation of the ERK and PKB pathways. The impact of this negative regulation was further emphasized by a potent transforming activity for S159A Gab2, but not wild‐type Gab2, in fibroblasts. These studies establish Gab2 as a proto‐oncogene, and a model in which receptor recruitment of Gab2 is tightly regulated via an intimate association with PKB. Release of this negative constraint enhances growth factor receptor signalling, possibly since Gab2 binding limits dephosphorylation and disassembly of receptor‐associated signalling complexes.
Development of 10 kW Three-Phase Grid Connected Inverter

In this paper, modeling, simulation and experimental study of a 10 kW three-phase grid connected inverter are presented. The mathematical model of the system is derived, and characteristic curves of the system are obtained in MATLAB with m-file for various switching frequencies, dc-link voltages and filter inductance values. The curves are used for parameter selection of three-phase grid connected inverter design. The parameters of the system are selected from these curves, and the system is simulated in Simulink. Modeling and simulation results are verified with experimental results at 10 kW for steady state response, at 5 kW for dynamic response and at -3.6 kVAr for reactive power. The inverter is controlled with Space Vector Pulse Width Modulation technique in d-q reference frame, and dSPACE DS1103 controller board is used in the experimental study. Grid current total harmonic distortion value and efficiency are measured 3.59% and 97.6%, respectively.