Miracle-dz/UniFAR-FTUs huggingface dataset:
Fast high-resolution 3D radar imaging based on 3D FISTA

This paper presents a fast high-resolution three-dimensional (3D) imaging method for 3D imaging systems based on the 2D aperture and wideband waveforms. The proposed method realizes high-resolution imaging by exploiting the sparsity of the radar targets. Conventional sparse 3D imaging methods consume excessive time and memory due to converting the 3D problem into the ID problem. Herein, utilizing an existing 3D sparse representation, the proposed method directly solves the 3D imaging problem by a novel 3D fast iterative shrinkage-thresholding algorithm (3D FISTA) in the frequency-wavenumber domain. The memory load and computation complexity issues are solved successfully by avoiding transforming the 3D problem to the ID case. Experimental results demonstrate that our method provides accurate 3D image reconstruction at a low computation cost.
Reliability Evaluation of Flood Releasing Structures Power Supply of Hydroelectric Power Station by Fault Tree Analysis

A new approach based on fault tree analysis to evaluate the overall reliability of flood releasing structures power supply system of hydroelectric power station is presented. This paper introduces the fault tree modelling and evaluation methods, and taking one hydroelectric power station in East China for example, a detailed fault tree model for flood releasing structures power supply system is established. Finally, the reliability of power supply system is assessed and the main contributors to reliability of power supply system have been identified, both qualitatively and quantitatively.
Association between survivin 31 G > C polymorphism and cancer risk : evidence from 33 case-control studies of 8028 cases and 9618 controls

Survivin is an inhibitor of apoptosis proteins and plays a crucial role in the development of cancer. Numerous studies have evaluated the association between survivin 31G>C polymorphism (rs9904341) and the risk of cancer, but the results of these studies remain inconclusive. Therefore, we conducted this updated meta-analysis to further examine this association. A total of 33 studies of 8028 cases and 9618 controls were identified. Overall, cancer risk was significantly elevated in the dominant model (OR = 1.170, 95% CI = 1.027-1.333), recessive model (OR = 1.387, 95% CI = 1.209-1.590), allele contrast model (OR = 1.192, 95% CI = 1.083-1.312) and homozygous codominant model (OR = 1.443, 95% CI = 1.214-1.714). A subgroup analysis by ethnicity identified a significant association among Asian populations under all genetic models. Furthermore, a subgroup analysis by cancer type showed a significant association between rs9904341 and gastric, colorectal and bladder cancers. Specifically, the correlation with colorectal cancer was significant in both the Asian and Caucasian populations, whereas the lung cancer and bladder cancer associations were significant in the Asian population, and the gastric cancer association was significant in the Caucasian population. Taken together, our results demonstrate that survivin 31G>C polymorphism is an important genetic risk factor of cancer.
First multi-partner demonstration of BGP-LS enabled inter-domain EON control with H-PCE

The control of Multi-domain Elastic Optical Networks (EON) is possible by combining H-PCE based computation, BGP-LS topology discovery, remote Instantiation via PCEP, and signaling via RSVP-TE. This paper presents the first multi-platform demonstration that fully validates such control architecture achieving multi-protocol interoperability.
Application of Composite Right/Left Handed (CRLH) Transmission Lines based on Complementary Split Ring Resonators (CSRRs) to the Design of Dual-Band Microwave Components

In this letter, composite right/left handed transmission lines based on complementary split ring resonators are applied to the design of dual-band microwave components. Specifically, impedance inverters operative at two (arbitrary) different frequencies (one of them within the left-handed band and the other within the right-handed band) are designed and applied to the implementation of a dual-band branch line hybrid coupler. The characterization of this device reveals good performance and dual-band operation. The fabricated device is small, fully planar, and vias are not required.
Blind equalization of multilevel turbo coded‐continuous phase frequency shift keying over MIMO channels

In this paper, multilevel turbo coded‐continuous phase frequency shift keying (MLTC‐CPFSK) is introduced and its bit error performance in multiple input multiple output (MIMO) fading channels are investigated considering a blind maximum likelihood channel estimation. Multilevel turbo coded signals with continuous phase modulation (CPM) provides low spectral occupancy and is suitable for power and bandwidth‐limited channels. Besides, antenna diversity is one of the best method to combat with multipath fading effects. The performance of 2LTC for 4‐ary CPFSK over AWGN, Rician (for Rician channel parameter K=10 dB) and Rayleigh channels are given for 1Tx–1Rx, 2Tx–1Rx and 2Tx–2Rx antenna configurations. Channel capacities of 2LTC‐4CPFSK signals are obtained as −5.26, −7.65 and −7.14 dB for 1Tx–1Rx, 2Tx–1Rx and 2Tx–2Rx antenna configurations, respectively. Baum–Welch (BW) algorithm is used to estimate the channel parameters. Bit error probabilities of 2 level turbo coded 4 CPFSK (2LTC‐4CPFSK) are drawn in the cases of no channel state information (CSI), BW estimation, and perfect CSI. Approximately 0.1 and 0.75 dB gains in Es/N0 are obtained using BW channel estimator for Rician and Rayleigh channels, respectively. Therefore, MLTC‐CPFSK with BW channel estimator has excellent performance in MIMO fading channels. Copyright © 2006 John Wiley & Sons, Ltd.
Surgical technique Circular hexapod external fi xation for periprosthetic tibial fracture

A poor soft tissue envelope often accompanies periprosthetic tibia fracture around a well-fixed total knee arthroplasty and the tibial stem leaves little room for screw fixation. This article describes the practicability and effectiveness of a novel surgical technique using circular hexapod external fixation, in patients with this clinical scenario. It was applied for fixation of periprosthetic tibia fracture in 2 patients. Contact between the external fixation pins and the prosthesis was avoided. Using a web-based software program, a gradual reduction in all planes was achieved. Adequate fixation, stability, reduction, and quick healing were obtained in the 2 cases, with minimal complications. The patients returned to their activity level a few months after external fixation removal. © 2017 The Authors. Published by Elsevier Inc. on behalf of The American Association of Hip and Knee Surgeons. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).
Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation.

AIMS Altered Ca(2+) handling in atrial fibrillation (AF) has been associated with dysregulated protein phosphatase 1 (PP1) and subcellular heterogeneities in protein phosphorylation, but the underlying mechanisms remain unclear. This is due to a lack of investigation into the local, rather than global, regulation of PP1 on different subcellular targets such as ryanodine receptor type 2 (RyR2), especially in AF. METHODS AND RESULTS We tested the hypothesis that impaired local regulation of PP1 causes RyR2 hyperphosphorylation thereby promoting AF susceptibility. To specifically disrupt PP1's local regulation of RyR2, we used the spinophilin knockout (Sp(-/-)) mice (Mus musculus) since PP1 is targeted to RyR2 via spinophilin. Without spinophilin, the interaction between PP1 and RyR2 was reduced by 64%, while RyR2 phosphorylation was increased by 43% at serine (S)2814 but unchanged at S2808. Lipid bilayer experiments revealed that single RyR2 channels isolated from Sp(-/-) hearts had an increased open probability. Likewise, Ca(2+) spark frequency normalized to sarcoplasmic reticulum Ca(2+) content was also enhanced in Sp(-/-) atrial myocytes, but normalized by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) inhibitors KN-93 and AIP and also by genetic inhibition of RyR2 S2814 phosphorylation. Finally, Sp(-/-) mice exhibited increased atrial ectopy and susceptibility to pacing-induced AF, both of which were also prevented by the RyR2 S2814A mutation. CONCLUSION PP1 regulates RyR2 locally by counteracting CaMKII phosphorylation of RyR2. Decreased local PP1 regulation of RyR2 contributes to RyR2 hyperactivity and promotes AF susceptibility. This represents a novel mechanism for subcellular modulation of calcium channels and may represent a potential drug target of AF.
The Moderating Role of Ambivalent Sexism: The Influence of Power Status on Perception of Rape Victim and Rapist

The authors examined the effect of ambivalent sexism on others' perceptions of alleged-rape incidents, in which there are socioeconomic status differences between the victims and their perpetrators. The dependent variables included measures of minimizing rape, blaming the victim, excusing the perpetrator, and determining the length of the recommended sentence. The results indicated 4 noteworthy findings: First, individuals who scored high on the hostile power relation (HPR) measure tended to minimize the seriousness of rape incidents. Second, the HPR measure moderated victim blame only in the powerful-man scenario. Third, participants who scored high on the HPR measure tended to believe that the alleged rapist held less responsibility. Fourth, female participants tended to give longer sentences.
A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma.

BACKGROUND & AIMS Percutaneous radiofrequency ablation is a recently introduced treatment for hepatocellular carcinoma, whereas ethanol injection is now a standard therapy. We compared their long-term outcomes. METHODS Two hundred thirty-two patients with hepatocellular carcinoma who had 3 or fewer lesions, each 3 cm or less in diameter, and liver function of Child-Pugh class A or B were entered onto a randomized controlled trial. The primary end point was survival, and the secondary end points were overall recurrence and local tumor progression. RESULTS One hundred eighteen patients were assigned to radiofrequency ablation and 114 to ethanol injection. The number of treatment sessions was smaller (2.1 times vs 6.4 times, respectively, P < .0001) and the length of hospitalization was shorter (10.8 days vs 26.1 days, respectively, P < .0001) in radiofrequency ablation than in ethanol injection. Four-year survival rate was 74% (95% CI: 65%-84%) in radiofrequency ablation and 57% (95% CI: 45%-71%) in ethanol injection. Radiofrequency ablation had a 46% smaller risk of death (adjusted relative risk, 0.54 [95% CI: 0.33-0.89], P = .02), a 43% smaller risk of overall recurrence (adjusted relative risk 0.57 [95% CI: 0.41-0.80], P = .0009), and an 88% smaller risk of local tumor progression (relative risk, 0.12 [95% CI: 0.03-0.55], P = .006) than ethanol injection. The incidence of adverse events was not different between the 2 therapies. CONCLUSIONS Judging from higher survival but similar adverse events, radiofrequency ablation is superior to ethanol injection for small hepatocellular carcinoma.
Fibromyalgia After Motor Vehicle Collision: Evidence and Implications

Objective:Assess currently available evidence regarding the ability of a motor vehicle collision (MVC) to trigger the development of fibromyalgia (FM). Methods:Consensus standards developed by the American College of Rheumatology Environmental Disease Study Group were used to assess the ability of an MVC to trigger FM. Results:Increasing evidence suggests that FM and related disorders are characterized by abnormalities in central nervous system function related to sensory processing, autonomic regulation, and neuroendocrine function. MVC trauma appears capable of triggering FM, but generally not through direct biomechanical injury. Instead, the evidence suggests that MVC trauma can act as a “stressor,” which in concert with other factors, such as an individual's biologic vulnerability, psychosocial factors, cultural factors, and so on, may result in the development of chronic widespread pain and other somatic symptoms. MVC trauma is only one of many stressors which can trigger such disorders, and the environment within which the stressor is experienced (biological and psychosocial) may largely determine whether there is an adverse physiologic result or not. Conclusions:The evidence that MVC trauma may trigger FM meets established criteria for determining causality, and has a number of important implications, both for patient care, and for research into the pathophysiology and treatment of these disorders.
Irregular Deposition of Cell Wall Polymers Resulting from Defective Cellulose Synthase Complexes

The crystalline cellulose microfibril is formed by the spontaneous association of about 36 β-D-glucan chains, which are simultaneously synthesised by a large membrane-localised multi-enzyme cellulose synthase complex. Antisense technology has been previously employed separately on two of the constituent cellulose synthase catalytic subunits (CesA) of the complex in potato ( Solanum tuberosum ), namely CesA2 and CesA4, to generate potato tuber cell walls with reduced cellulose content. Genetic crossing of two transgenic potato lines csr2-1 and csr4-8 was carried out to investigate the effects of two defective CesAs in the same genetic background, with respect to cellulose deposition in the potato tuber cell walls. It was striking to observe, through fluorescence microscopy with calcofluor white, a strong fluorescence in the cell corners and less prominent and uneven fluorescence around the cells of the csr2 tubers as compared to others. It was also noted that these phenotypes were not pronounced in the csr2/csr4 double transformants as expected.
7 q 31 : A Genome-Wide Analysis Common Familial Colorectal Cancer Linked to Chromosome

Present investigations suggest that f30% of colorectal cancer cases arise on the basis of inherited factors. We hypothesize that the majority of inherited factors are moderately penetrant genes, common in the population. We use an affected sibling pair approach to identify genetic regions that are coinherited by siblings with colorectal cancer. Individuals from families with at least two siblings diagnosed with colorectal adenocarcinoma or high-grade dysplasia were enrolled. Known familial colorectal cancer syndromes were excluded. A genome-wide scan on 151 DNA samples from 70 kindreds was completed using deCODE 1100 short tandem repeat marker set at an average 4-cM density. Fine mapping on a total of 184 DNAs from 83 kindreds was done in regions suggesting linkage. Linkage analysis was accomplished with Merlin analysis package. Nonparametric linkage analysis revealed three genetic regions with logarithm of the odds (LOD) scores z2.0: Ch. 3q29, LOD 2.61 (P = 0.0003); Ch. 4q31.3, LOD 2.13 (P = 0.0009); and Ch. 7q31.31, LOD 3.08 (P = 0.00008). Affected siblings with increased sharing at the 7q31 locus have a 3.8-year (F 3.5) earlier age of colorectal cancer onset although this is not statistically significant (P = 0.11). No significant linkage was found near genes causing known syndromes or regions previously reported (8q24, 9q22, and 11q23). The chromosome 3q21–q24 region reported to be linked in colorectal cancer relative pairs is supported by our study, albeit a minor peak (LOD 0.9; P = 0.02). No known familial cancer genes reside in the 7q31 locus, and thus the identified region may contain a novel susceptibility gene responsible for common familial colorectal cancer. [Cancer Res 2008;68(21):8993–7]
Association of hepatic lipase with proteoglycans stimulates the production of proteoglycans in vivo and in vitro Published, JLR Papers in Press, April 21, 2004. DOI 10.1194/jlr.M300372-JLR200

HL is synthesized in hepatocytes and functions while bound to heparan sulfate proteoglycans (HSPGs) in sinusoidal endothelial cells. The HL-mediated uptake of lipoprotein requires cell-surface HSPG. The present study tested whether HL plays a role in the production of HSPG. The production of HSPG in Chinese hamster ovary (CHO) cells was determined by measuring the incorporation of 35SO4 into PGs. HL-producing HL-CHO cells showed approximately 30% more cellular PG than did wild-type (WT) cells. In contrast, PG production in cells producing a membrane-anchored HL-glycophosphatidylinositol (GPI) that was not bound to HSPG was virtually identical to that in WT cells. When purified HL was added to the WT- or HL-GPI cells, PG production increased significantly to a level similar to that of the HL-secreting cells, suggesting that the binding of HL to HSPG triggered the increased HSPG production. Heparin reduced PG production in HL-producing cells, confirming that PG production is stimulated only when HL is present as a ligand for HSPG. Real-time PCR and Northern blots demonstrated that PG production was significantly reduced in animals lacking HL. Together, these data suggest that the binding of HL to PG on the cell surface exerts a positive feedback on cellular PG production.
Motion Segmentation based on On-line Non-parametric Learning using RGB-D Data

Motion segmentation is a fundamental technology in many robotic applications, such as mapping and navigation in dynamic environments. In this study, we propose a novel motion segmentation approach based on on-line non-parametric learning using RGB-D data. The proposed approach requires no prior information, such as hand-labelled initial segmentation. Foreground cues are derived from dense optical flow with the homography constraint. Visual and depth information of moving objects are learned on the fly to maintain a foreground model, which is incrementally updated during the iterations. We evaluate the approach using public sequences. The results demonstrate that our approach is able to effectively segment moving objects with a freely moving RGB-D camera.
Conformational flexibility of RecA protein filament: Transitions between compressed and stretched states

RecA protein is a central enzyme in homologous DNA recombination, repair and other forms of DNA metabolism in bacteria. It functions as a flexible helix‐shaped filament bound on stretched single‐stranded or double‐stranded DNA in the presence of ATP. In this work, we present an atomic level model for conformational transitions of the RecA filament. The model describes small movements of the RecA N‐terminal domain due to coordinated rotation of main chain dihedral angles of two amino acid residues (Psi/Lys23 and Phi/Gly24), while maintaining unchanged the RecA intersubunit interface. The model is able to reproduce a wide range of observed helix pitches in transitions between compressed and stretched conformations of the RecA filament. Predictions of the model are in agreement with Small Angle Neutron Scattering (SANS) measurements of the filament helix pitch in RecA::ADP‐AlF4 complex at various salt concentrations. Proteins 2006. © 2006 Wiley‐Liss, Inc.
Trade impacts of South Asian Free Trade Agreements: The case of Sri Lanka

This article aims to examine the trade effects of the South Asian FTAs including regional and bilateral ones with a focus on Sri Lanka, by applying a gravity trade model as an analytical framework. The study specifically targets the following three FTAs: the South Asian Free Trade Agreement (SAFTA) enforced in 2006, the India-Sri Lanka Free Trade Agreement (ISFTA) in 2001, and the Pakistan-Sri Lanka Free Trade Agreement (PSFTA) in 2005. The outcomes of the gravity trade model estimation suggested that the trade creation effects were identified in the ISFTA, while those were not verified in the SAFTA, and that the PSFTA had the trade creation effects only on the Sri Lankan imports. Those results seems to reflect the differentials in the preferential tariff rates and in the presence of negative list among the individual FTA frameworks. In particular, ISFTA could have the predominant positive effects on Sri Lankan trade flows due to its lowest preferential tariff rates since the early stage of its enforcement, and thus the SAFTA effect might be crowded out at the current stage of Sri Lankan trade.
Regulation of Thrombocyte Adenylate Cyclase Activity in Terminal Renal Failure

In a recent paper in Thrombosis and Haemostasis Michalak et al. (1) partially attributed bleeding diathesis in their patients to a cAMP-mediated suppression of platelet activation as a consequence of an elevated adenylate cyclase activity in uremia (2, 3). However, in one cited study (2) a comparison of the enzyme activity between healthy persons and chronic hemodialyzed patients showed no significant differences between both groups. We assayed thrombocyte adenylate cyclase activity in 14 nondiabetic chronically hemodialyzed patients (age 24-56 years) and 14 healthy individuals (age 24-58 years) in an age/sex matched study. Adenylate cyclase activity was assayed in thrombocyte membranes, freshly prepared from sodium-citrate anticoagulated blood as described elsewhere (4), according to the method of
Enriching s4U‐RNA Using Methane Thiosulfonate (MTS) Chemistry

Metabolic labeling of cellular RNA is a useful approach to study RNA biology. 4‐Thiouridine (s4U) is a convenient nucleoside for metabolic labeling because it is cell permeable and is incorporated into newly transcribed RNA, and the sulfur moiety provides a handle for biochemical purification. However, a critical step in the purification of s4U‐RNA is the efficiency of the chemistry used to enrich s4U‐RNA. Here, we present a protocol for s4U‐RNA enrichment that includes efficient and reversible covalent chemistry to biotinylate s4U‐RNA using the activated disulfide methane thiosulfonate conjugated to biotin (MTS‐biotin), followed by enrichment on streptavidin beads. The efficiency of this chemistry reduces enrichment bias and requires less starting material, thereby expanding the utility of s4U to study RNA biology. © 2016 by John Wiley & Sons, Inc.