Miracle-dz/UniFAR-FTUs huggingface dataset:
Do anti-platelet drugs improve duration of continuous renal replacement therapy? A retrospective cohort study in cardiac ICU patients

Objective: The objective of this study was to investigate the impact of anti-platelet drug/s on duration of continuous renal replacement therapy (CRRT) in those patients where anti-coagulants were not used due to certain contraindications and in cases where patients were on anti-platelet drugs and were given anti-coagulant during CRRT. Method: This single-center, retrospective cohort study was conducted using the medical records patients treated with CRRT in the cardiac ICU of the inpatient urban facility, located in North India. Data was collected from only those patients who received CRRT for the duration of at least 12 h. Patient’s in NAC group were not on any anti-platelet/s and did not receive anti-coagulant during CRRT. AC and AP group patients received anti-coagulant alone or were already on anti-platelet/s and did not receive anti-coagulant respectively while ACAP group patients were on anti-platelet drug/s and also received anti-coagulant during CRRT. Result: Patients in AC, AP, or ACAP group showed significantly (p < 0.001) higher CRRT filter life compared to NAC group. The median CRRT filter life was significantly higher in the ACAP group compared to AC (p < 0.05) and AP (p < 0.001) groups. Conclusion: This study indicates that systemic anti-platelet therapy can provide additional support in critical patients undergoing CRRT even with or without anti-coagulant therapy. However, the increase in CRRT filter life was more profound in patients who were on anti-platelet/s and also received anti-coagulant drug/s during CRRT.
Declining well-being during the COVID-19 pandemic reveals US social inequities

Background The COVID-19 pandemic led to mental health fallout in the US; yet research about mental health and COVID-19 primarily rely on samples that may overlook variance in regional mental health. Indeed, between-city comparisons of mental health decline in the US may provide further insight into how the pandemic is disproportionately affecting at-risk groups. Purpose This study leverages social media and COVID-19-city infection data to measure the longitudinal (January 22- July 31, 2020) mental health effects of the COVID-19 pandemic in 20 metropolitan areas. Methods We used longitudinal VADER sentiment analysis of Twitter timelines (January-July 2020) for cohorts in 20 metropolitan areas to examine mood changes over time. We then conducted simple and multivariate Ordinary Least Squares (OLS) regressions to examine the relationship between COVID-19 infection city data, population, population density, and city demographics on sentiment across those 20 cities. Results Longitudinal sentiment tracking showed mood declines over time. The univariate OLS regression highlighted a negative linear relationship between COVID-19 city data and online sentiment (β = -.017). Residing in predominantly white cities had a protective effect against COVID-19 driven negative mood (β = .0629, p < .001). Discussion Our results reveal that metropolitan areas with larger communities of color experienced a greater subjective well-being decline than predominantly white cities, which we attribute to clinical and socioeconomic correlates that place communities of color at greater risk of COVID-19. Conclusion The COVID-19 pandemic is a driver of declining US mood in 20 metropolitan cities. Other factors, including social unrest and local demographics, may compound and exacerbate mental health outlook in racially diverse cities.
NNC 26-9100 increases Aβ1-42 phagocytosis, inhibits nitric oxide production and decreases calcium in BV2 microglia cells

Microglia are the resident immune cell of the brain involved in the development and progression of Alzheimer’s disease (AD). Modulation of microglia activity represents a potential mechanism for treating AD. Herein, the compound NNC 26–9100 (NNC) was evaluated in toxicity, nitric oxide release, Aβ1–42 uptake and cytosolic calcium assays during lipopolysaccharide (LPS)-activated conditions using mouse BV2 microglia cells. After 24 hours, LPS increased cell toxicity in the alamar blue and lactate dehydrogenase assays, increased nitrite release, and increase cytoplasmic calcium. Addition of NNC decreased the LPS-induce lactate dehydrogenase release, had no effect in the alamar blue assay, decreased nitrite release and decreased cytosolic calcium. In the absence of LPS, NNC increased uptake of FITC-tagged Aβ1–42. These data demonstrate that NNC treatment decreases nitrosative stress and microglia cell damage during LPS-induced activation and enhances phagocytosis of Aβ1–42 during non-inflammatory conditions. Thus, NNC 26–9100 may have beneficial effects in AD and in inflammatory diseases of the brain through enhancement of microglial Aβ clearance, and cell protective effects through prevention of elevated cytosolic calcium and inhibition of nitric oxide release.
Transitioning health workers from PEPFAR contracts to the Uganda government payroll

Abstract Although increasing public spending on health worker (HW) recruitments could reduce workforce shortages in sub-Saharan Africa, effective strategies for achieving this are still unclear. We aimed to understand the process of transitioning HWs from President’s Emergency Plan for AIDS Relief (PEPFAR) to Government of Uganda (GoU) payrolls and to explore the facilitators and barriers encountered in increasing domestic financial responsibility for absorbing this expanded workforce. We conducted a multiple case study of 10 (out of 87) districts in Uganda which received PEPFAR support between 2013 and 2015 to expand their health workforce. We purposively selected eight districts with the highest absorption rates (‘high absorbers’) and two with the lowest absorption rates (‘low absorbers’). A total of 66 interviews were conducted with high-level officials in three Ministries of Finance, Health and Public Service (n = 14), representatives of PEPFAR-implementing organizations (n = 16), district health teams (n = 15) and facility managers (n = 22). Twelve focus groups were conducted with 87 HWs absorbed on GoU payrolls. We utilized the Consolidated Framework for Implementation Research to guide thematic analysis. At the sub-national level, facilitators of transition in ‘high absorber’ districts were identified as the presence of transition ‘champions’, prioritizing HWs in district wage bill commitments, host facilities providing ‘bridge financing’ to transition workforce during salary delays and receiving donor technical support in district wage bill analysis—attributes that were absent in ‘low absorber’ districts. At the national level, multi-sectoral engagements (incorporating the influential Ministry of Finance), developing a joint transition road map, aligning with GoU salary scales and recruitment processes emerged as facilitators of the transition process. Our case studies offer implementation research lessons on effective donor transition and insights into pragmatic strategies for increasing public spending on expanding the health workforce in a low-income setting.
FRETboard: semi-supervised classification of FRET traces.

Förster resonance energy transfer (FRET) is a useful phenomenon in biomolecular investigations, as it can be leveraged for nano-scale measurements. The optical signals produced by such experiments can be analyzed by fitting a statistical model. Several software tools exist to fit such models in an unsupervised manner, but lack the flexibility to adapt to different experimental setups and require local installations. Here we propose to fit models to optical signals more intuitively by adopting a semi-supervised approach, in which the user interactively guides the model to fit a given dataset, and introduce FRETboard, a web tool that allows users to provide such guidance. We show that our approach is able to closely reproduce ground truth FRET statistics in a wide range of simulated single-molecule scenarios, and correctly estimate parameters for up to eleven states. On in vitro data we retrieve parameters identical to those obtained by laborious manual classification in a fraction of the required time. Moreover, we designed FRETboard to be easily extendable to other models, allowing it to adapt to future developments in FRET measurement and analysis.
Nrf2-BDNF-TrkB pathway contributes to cortical hemorrhage-induced depression, but not sex differences

Post-stroke depression, observed in 30-50% of stroke patients, negatively affects quality of life and mortality. The pathogenesis of post-stroke depression is complex, but heightened reactive oxygen species production and inflammation might be two key factors. We have reported that intracerebral hemorrhage (ICH) in cerebral cortex produces depression-like behavior in young male mice. Here, we found that mice lacking nuclear factor erythroid-derived 2-related factor 2 (Nrf2), a transcription factor that upregulates antioxidant proteins and trophic factors such as brain-derived neurotrophic factor (BDNF), had more severe depression-like behavior than wild-type mice at days 21 to 28 after cortical ICH (c-ICH). Moreover, the expression of Nrf2, heme oxygenase-1, BDNF, and TrkB were significantly decreased in wild-type mice after c-ICH. Interestingly, TP-500 (2 mg/kg), a potent Nrf2 inducer, decreased the inflammatory response and reactive oxygen species production on day 28 after c-ICH and improved depression-like behaviors. TrkB receptor antagonist ANA-12 abolished this anti-depression effect. Depression was more severe in female than in male wild-type mice after ICH, but TP-500 improved depression-like behavior in females. These results suggest that downregulation of Nrf2-BDNF-TrkB signaling contributes to development of post-stroke depression, and that Nrf2 inducer TP-500 might improve depression after c-ICH.
Understanding small ORF diversity through a comprehensive transcription feature classification

Abstract Small open reading frames (small ORFs/sORFs/smORFs) are potentially coding sequences smaller than 100 codons that have historically been considered junk DNA by gene prediction software and in annotation screening; however, the advent of next-generation sequencing has contributed to the deeper investigation of junk DNA regions and their transcription products, resulting in the emergence of smORFs as a new focus of interest in systems biology. Several smORF peptides were recently reported in non-canonical mRNAs as new players in numerous biological contexts; however, their relevance is still overlooked in coding potential analysis. Hence, this review proposes a smORF classification based on transcriptional features, discussing the most promising approaches to investigate smORFs based on their different characteristics. First, smORFs were divided into non-expressed (intergenic) and expressed (genic) smORFs. Second, genic smORFs were classified as smORFs located in non-coding RNAs (ncRNAs) or canonical mRNAs. Finally, smORFs in ncRNAs were further subdivided into sequences located in small or long RNAs, whereas smORFs located in canonical mRNAs were subdivided into several specific classes depending on their localization along the gene. We hope that this review provides new insights into large-scale annotations and reinforces the role of smORFs as essential components of a hidden coding DNA world.
Study of natural adsorbent chitosan and derivatives for the removal of caffeine from water

The adsorption of caffeine was evaluated using natural adsorbent chitosan and three derivates of the material. Raw, H 2 O 2 pre-treated, and a chemically altered chitosan were compared to activated carbon. Activated carbon was found to have a high affinity for caffeine (98% removal) while raw chitosan performed poorly with an average adsorption of 15.9%. Batch tests in acidic and basic conditions as well as increasing dosage did not have an effect on the performance. Chemical modifications to chitosan included calcinated mesoporous materials and non-calcinated materials, both of which increased chitosan adsorption of caffeine to 29 and 40%, respectively. Hydrogen peroxide pre-treated chitosan performed best of chitosan-based adsorbents, and reached a 46% removal of caffeine in batch adsorption tests. The majority of the adsorbents had low correlation to the Langmuir, Freundlich, and Redlich–Peterson isotherm models. However, data were sufficient to compare adsorption capacity for caffeine among activated carbon, chitosan, and chitosan derivatives.
Survival of presolar p-nuclide carriers in the nebula revealed by stepwise leaching of Allende refractory inclusions

Step leaching of fine-grained refractory inclusions from Allende reveals the presence of large 84Sr anomalies. The 87Rb-87Sr radiochronometer provides key insights into the timing of volatile element depletion in planetary bodies, yet the unknown nucleosynthetic origin of Sr anomalies in Ca-Al–rich inclusions (CAIs, the oldest dated solar system solids) challenges the reliability of resulting chronological interpretations. To identify the nature of these Sr anomalies, we performed step-leaching experiments on nine unmelted CAIs from Allende. In six CAIs, the chemically resistant residues (0.06 to 9.7% total CAI Sr) show extreme positive μ84Sr (up to +80,655) and 87Sr variations that cannot be explained by decay of 87Rb. The extreme 84Sr but more subdued 87Sr anomalies are best explained by the presence of a presolar carrier enriched in the p-nuclide 84Sr. We argue that this unidentified carrier controls the isotopic anomalies in bulk CAIs and outer solar system materials, which reinstates the chronological significance of differences in initial 87Sr/86Sr between CAIs and volatile-depleted inner solar system materials.
Tumbling and anomalous alignment of optically levitated anisotropic microparticles in chiral hollow-core photonic crystal fiber

Tumbling motion of levitated anisotropic vaterite particle in chiral hollow core fiber results in anomalous optical alignment. The complex tumbling motion of spinning nonspherical objects is a topic of enduring interest, both in popular culture and in advanced scientific research. Here, we report all-optical control of the spin, precession, and nutation of vaterite microparticles levitated by counterpropagating circularly polarized laser beams guided in chiral hollow-core fiber. The circularly polarized light causes the anisotropic particles to spin about the fiber axis, while, regulated by minimization of free energy, dipole forces tend to align the extraordinary optical axis of positive uniaxial particles into the plane of rotating electric field. The end result is that, accompanied by oscillatory nutation, the optical axis reaches a stable tilt angle with respect to the plane of the electric field. The results reveal new possibilities for manipulating optical alignment through rotational degrees of freedom, with applications in the control of micromotors and microgyroscopes, laser alignment of polyatomic molecules, and study of rotational cell mechanics.
Listen But Do Not Touch: Using a Smartphone Acoustic Device to Investigate Bat Activity, with Implications for Community-Based Monitoring

The monitoring of bats across the world is mostly conducted using invasive mist-netting, whereby vertical nets are placed to capture bats mid-flight. Many studies have demonstrated how this approach causes sampling bias, is labor-intensive and increases the risk of white-nose syndrome fungus, Pseudogymnoascus destructans, transmission among bats. Increasingly, acoustic devices are being employed to collect data on bat activity and richness. Community-based monitoring is an important data collection source for bat monitoring programs in countries such as the UK (National Bat Monitoring Program), whereby walking bat transects are conducted using bat detectors. Since the launch of smartphone devices to record and auto-identify bat echolocation calls, the quality of data collection that community members can collect has increased significantly, however, this approach is seldom used to generate data in scientific studies. In our study, we have showcased how our study design paired with state of the art acoustic monitoring devices, can be applied to community-based monitoring of bats across the world. Through employing smartphone acoustic devices, we have determined how primary and secondary vegetation cover are predictors of bat species occurrence and identified the importance of riverine and deciduous swamp habitats for rare bat species in southwestern Ontario.
Male Chemical Signalling to Recruit Females in the Greater Short-Nosed Fruit Bat Cynopterus sphinx

Mate attraction via chemosignalling is common in group-living mammals. In the greater short-nosed fruit bats, Cynopterus sphinx, it remains unclear whether males use chemosignals to attract females. Here, we use field observations to describe patterns of male chemosignalling in this species, then use preference test in captivity to infer the function of chemosignals. We observed that males engage in chemosignalling through wing fanning after marking their leaf ‘tent' roosts with saliva. The male fanned each wing alternatively and vigorously and performed frequent tongue flicks to the wing membrane. Such behaviour is exhibited towards females that returned to the tent. Afterwards, the male embraced the female with both wings. Wing fanning and tent marking occurred more often during the mating season than the non-mating season. To infer the role of chemosignals in recruiting females, we performed two different choice tests. In the first test, we tested whether females preferred the tent containing cotton balls that were rubbed gently and repeatedly on the ventral side of the plagiopatagium of the male, versus a control tent without any conspecific odour. In the second test, we tested whether females preferred a tent that was marked by a male's saliva versus a control tent without such markings. The result of both tests indicated that females recognized the saliva and ‘scent’ from the wings of males, since females always preferred tents with male chemosignals over the controls. Our findings suggest that the recruitment of females and subsequent formation of a harem in the greater short-nosed fruit bats is influenced by male chemosignals.
Cranial Morphology of the Flat-Headed Bat Myotis planiceps (Chiroptera: Vespertilionidae) in the Context of American Myotis

Myotis planiceps is an insectivorous species with a distinctive flat-headed morphology among Myotis species. Its distribution is restricted to the northeastern Mexico highlands, and uses trees of Yucca carnerosana to roost. The particular ecological and morphological characteristics of this species make it a likely resource-use specialist. We evaluated the morphological specialization of M. planiceps as compared with thirteen American congeners belonging to different dietary categories, using a geometric morphometric protocol and multivariate statistical analyses. We estimated morphological differences across dietary categories, including M. planiceps as a separate group, and evaluated the effect of cranial size and diet on variations in cranial morphology. We found a significant differentiation of this species in all the cranial shape characters, with soft insectivores as the dietary group closest to M. planiceps. Additionally, diet explained similar percentages of shape variance in cranial and mandibular characters, and the highest interaction between diet and cranial size was recorded in the braincase. In general, the smallest sizes and thinner skulls were observed in soft insectivores. Our findings do not support a significant relationship between skull shape characters, described by the first principal component, and hardness of food items, but we found a significant association with the mandible shape. No phylogenetic structure was observed in the residual variance of these models. We found trends of change in cranial morphology associated with specialized habitats, the mandibular characters being more contrasting in the fishing bat M. vivesi, and the braincase morphology being more contrasting in M. planiceps, a species that lives in restricted habitats and probably feeds on soft insects.
A Survey of Blind Orientation and Mobility Specialists about the Accommodations and Teaching Strategies They Use When Providing Orientation and Mobility Services

Introduction: The purpose of the study was to survey orientation and mobility (O&M) instructors who are blind concerning the identification of accommodations, teaching techniques, and resources to teach students with visual impairments (i.e., blindness or low vision). Methods: The study utilized an online survey via Qualtrics (2019) with 27 closed- and open-ended items to identify accommodations, teaching techniques, and resources needed. The survey was e-mailed to membership and certification organizations requesting O&M instructors who are blind to participate for 12 weeks. The participants were 15 O&M specialists, mostly male and Caucasian. Survey data were then analyzed using descriptive statistics. Results: Forty percent of the participants reported that there were minimal standards that they had to demonstrate prior to their admittance into an O&M program. About one-fourth of the participants mentioned their program was modified because of their visual impairment. Eleven participants (73%) reported that their nonvisual instructional strategies and techniques were predominantly gained through their university programs or other visually impaired instructors (27%, n = 4). Discussion: Aspects of this study that are similar to the current literature are smaller faculty-to-student ratios for blindfold or simulation cane courses, accommodations used by participants, and suggestions for monitoring the safety of students. The results revealed the participants’ strong belief in the importance of immersion training, the use of the Structured Discovery Cane Travel (SDCT), nonvisual skills during O&M instruction, sleep shades, and students’ problem-solving abilities. Implication for practitioners: Although the participants had received SDCT immersion training, most personnel preparation programs approved by the Association for the Education and Rehabilitation of Blind and Visually Impaired do not use this method. For this reason, it is important for faculty to identify best teaching practices from among all programs and to integrate these practices into their curricula. Sharing best practices could strengthen all programs. Moreover, students with visual impairments should be taught early about self-advocacy and the ability to have helpful knowledge about one’s skills at a university and in the workplace.
The Award Winning Academic Performer

Business education is undergoing paradigmatic changes, and business schools are feeling the brunt of these changes. This article proposes that “business as usual” is over for traditional business schools. Using Ohmae’s 3Cs—customers, competitors, and company—as an analytical framework, I examine important changes from different vantage points. From the perspective of customers, the focus lies on technological and value changes. In terms of competitors, the analysis centers on the growing number of alternative suppliers of business education and the geographic shifts in the business school landscape. As to the company dimension, I comment on the vast number and heterogeneity of business schools and suggest that they are heading toward a business model competition. In considering potential development paths for business schools, the article concludes that they require radical innovations to stay relevant.