Miracle-dz/UniFAR-FTUs huggingface dataset:
hypercapnia autoregulation during transient hypocapnia and Continuous estimates of dynamic cerebral

[PDF] [Full Text] [Abstract] , March 7, 2013; . Emerg Med J Ryan M Kammeyer, Michael S Pargett and Ann E Rundell continuous chest compression CPR techniques Comparison of CPR outcome predictors between rhythmic abdominal compression and [PDF] [Full Text] [Abstract] , March 1, 2014; 2 (3): . PHY2 Paola Maggio, Angela S. M. Salinet, Thompson G. Robinson and Ronney B. Panerai autoregulation and cerebrovascular reactivity on neurovascular coupling: interaction with dynamic cerebral 2 Influence of CO [PDF] [Full Text] [Abstract] , May , 2014; 31 (5): 394-400. Emerg Med J Ryan M Kammeyer, Michael S Pargett and Ann E Rundell continuous chest compression CPR techniques Comparison of CPR outcome predictors between rhythmic abdominal compression and [PDF] [Full Text] [Abstract] , June , 2014; 55 (6): 3509-3516. IOVS Lin Wang, Grant Cull, Claude F. Burgoyne, Simon Thompson and Brad Fortune Revealed in Experimental Glaucoma Longitudinal Alterations in the Dynamic Autoregulation of Optic Nerve Head Blood Flow [PDF] [Full Text] [Abstract] , August 1, 2014; 117 (3): 205-213. J Appl Physiol Pedro M. Castro, Rosa Santos, João Freitas, Ronney B. Panerai and Elsa Azevedo maneuver: comparison between healthy and autonomic dysfunction subjects Autonomic dysfunction affects dynamic cerebral autoregulation during Valsalva
Increased activity in respiratory-related nuclei may reflect compensatory mechanisms DBA / 1 imaging data are consistent with imaging changes in human SUDEP

Sudden unexpected death in epilepsy (SUDEP) is a major concern for patients with epilepsy. In most witnessed cases of SUDEP generalized seizures and respiratory failure preceded death, and pre-mortem neuroimaging studies in SUDEP patients observed changes in specific subcortical structures. Our study examined the role of subcortical structures in the DBA/1 mouse model of SUDEP using manganeseenhanced magnetic resonance imaging (MEMRI). These mice exhibit acousticallyevoked generalized seizures leading to seizure-induced respiratory arrest (S-IRA) that results in sudden death unless resuscitation is rapidly instituted. MEMRI data in the DBA/1 mouse brain immediately after acoustically-induced S-IRA were compared to data in C57 (control) mice that were exposed to the same acoustic stimulus that did not trigger seizures. The animals were anesthetized and decapitated immediately after seizure in DBA/1 mice and after an equivalent time in control mice. Comparative T1 weighted MEMRI images were evaluated using a 14T MRI scanner and quantified. We observed significant increases in activity in DBA/1 mice as compared to controls at previously-implicated auditory (superior olivary complex) and sensorimotor-limbic [periaqueductal gray (PAG) and amygdala] networks and also in structures in the respiratory network. The activity at certain raphe nuclei was also increased, suggesting activation of serotonergic mechanisms. These data are consistent with previous findings
The Heat Resistance of Streptococcus faecalis

The log survivor/time graph for mature cultures of one strain of Streptococcus faecalis was not always straight over its whole length. A preliminary period of slow death was frequently observed, and a final similar period less often. The log survivor/time graphs of young cultures varied in shape with age of culture and often showed an initial rapid death-rate, passing suddenly into a slower one. The heat resistance of three strains was considerably influenced by the age of the culture. Resistance, judged either by the Decimal Reduction Time or the time taken to reach 99.9 yo mortality, was increased by transfer to fresh medium and fell during the lag phase of growth, reaching a minimum as rapid reproduction began. A second maximum in heat resistance occurred when growth became slow: thereafter the resistance gradually fell to that of mature cultures. The incubation temperature affected the heat resistance of young cultures, the effect of high temperatures being particularly marked and resulting in increased resistance, except with cultures 1 hr. old or less.
Specify the Meaning of What We Say Speakers ' Acceptance of Real-Time Speech Exchange Indicates That We Use Auditory Feedback to

Speech is usually assumed to start with a clearly defined preverbal message, which provides a benchmark for selfmonitoring and a robust sense of agency for one’s utterances. However, an alternative hypothesis states that speakers often have no detailed preview of what they are about to say, and that they instead use auditory feedback to infer the meaning of their words. In the experiment reported here, participants performed a Stroop color-naming task while we covertly manipulated their auditory feedback in real time so that they said one thing but heard themselves saying something else. Under ideal timing conditions, two thirds of these semantic exchanges went undetected by the participants, and in 85% of all nondetected exchanges, the inserted words were experienced as self-produced. These findings indicate that the sense of agency for speech has a strong inferential component, and that auditory feedback of one’s own voice acts as a pathway for semantic monitoring, potentially overriding other feedback loops.
Comparative cytogenetics among species of the Astyanax scabripinnis complex: evolutionary and biogeographical inferences

Karyotype data are presented for distinct species of the genus Astyanax from four rivers belonging to three different hydrographic basins of the State of Parana, Brazil (Verde River - Tibagi basin, Acungui River - Ribeira basin, and Santo Antonio and Jaguariaiva Rivers - Jaguariaiva basin). Three karyotypic forms were identified, here denominated karyotype A (2n = 50 chromosomes, with 8m+18sm+10st+14a, and thirteen 18S rDNA sites); karyotype B (2n = 50 chromosomes, with 8m+18sm+10st+1f4a, and four 18S rDNA sites); and karyotype C (2n = 48 chromosomes, with 10m+16sm+10st+12a, and eight 18S rDNA sites). The pattern of constitutive heterochromatin was similar among the three karyotypic forms, with few differences. The 5S rDNA corresponds to a synapomorphic character regarding its number and chromosomal localization. The karyotypic form A occurs in the distribution center of the type locality of A. paranae, in the proximities of the town of Castro (Tibagi basin), and may have reached the headwaters of the Ribeira River by the breakdown of geographical barriers. The karyotypic forms B and C are sympatric and syntopic, occurring solely in the Jaguariaiva River basin. Our hypothesis is that the karyotypic form A corresponds to the species A. paranae and forms B and C correspond to other species of the A. scabripinnis complex.
Carlsson digital discourse Swedish politicians and new media : Democracy , identity and populism in a

The empirical material of this article consists of interviews with politicians in Västerbotten, an area in the north of Sweden. The aim of the article is to identify and analyse how these politicians relate to digital information technology and new media. What democratic opportunities and risks of information technology and new media are reflected in interviews with the politicians? What does this technology and these media mean for politicians’ political strategies and for their identity production as professional politicians? We argue that the interview data reflect two partly contradictory political identities: on the one side a progressive and modern political identity, and on the other a ‘real’ and ‘authentic’ political identity. However, both identities are consistent with a digital discourse and are populist due to their pro-technological character.
The Geometrical Robustness of roll formed profiles in ultra high strength steels

To determine the geometrical robustness and process stability of roll formed profiles in Ultra High Strength Steel (UHSS) an investigation combining physical testing and FE simulation was conducted. The influence of roll forming on the tolerances of holes punched prior to roll forming and on the profile springback was studied. Measurements confirm that hole shapes are preserved also close to flange edges in UHSS, and that the standard design recommendations apply close to formed radii. This data will be used in new design rules for roll formed UHSS profiles. The conclusions are that UHSS are suitable for roll forming and that holes with high tolerance demands can be pre-punched in the vicinity of flange edges prior to roll forming.
AMLs rearranged MLL-AF 9 is critical for the pathogenesis of a subset of EVI 1

Prepublished online May 2, 2012; Beverloo, Hartmut Döhner, Wendy A. Hudson, John H. Kersey, Ruud Delwel and Ashish R. Kumar Krivtsov, Elwin Rombouts, Scott A. Armstrong, Erdogan Taskesen, Jurgen R. Haanstra, H. Berna Eric M.J. Bindels, Marije Havermans, Sanne Lugthart, Claudia Erpelinck, Elizabeth Wocjtowicz, Andrei V. AMLs rearranged MLL-AF9 is critical for the pathogenesis of a subset of EVI1 http://bloodjournal.hematologylibrary. org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylibrary. org/site/misc/rights.xhtml#reprints Information about ordering reprints may be found online at: http://bloodjournal.hematologylibrary. org/site/subscriptions/index.xhtml Information about subscriptions and ASH membership may be found online at:
Regulating Ocular Apoptosis in Zebrafish gdf 6 a Mutants

Citation: Pant SD, March LD, Famulski JK, French CR, Lehmann OJ, Waskiewicz AJ. Molecular mechanisms regulating ocular apoptosis in zebrafish gdf6a mutants. Invest Ophthalmol Vis Sci. 2013;54:5871–5879. DOI: 10.1167/iovs.12-11315 PURPOSE. To characterize the molecular mechanisms underlying retinal apoptosis induced by loss of Gdf6, a TGFb ligand. METHODS. The role of Gdf6 in regulating apoptosis was studied using a zebrafish gdf6a / mutant, which encodes a truncated, nonfunctional protein. To investigate whether intrinsic or extrinsic apoptotic mechanisms were involved, morpholino antisense oligonucleotides targeting baxa, baxb, and p53 were employed. Caspase-3 immunohistochemistry (IHC) was performed to assay apoptosis. Pharmacologic inhibition (using SB203580) and IHC were used to investigate the role of p38 mitogen activated protein (MAP) kinase activation in gdf6a / induced apoptosis. To assess the role of Gdf6a in transcriptional regulation of TGFb signal transducers, in situ hybridization (ISH) was performed using probes to smad1, 5, 7, and 8.
, Resonance Binding Assays Insights into PARP Inhibitors ' Selectivity Using Fluorescence Polarization and Surface Plasmon

PARP inhibitors are an exciting new class of antineoplastic drugs that have been proven to be efficacious as single agents in cancer settings with inherent DNA repair defects, as well as in combination with DNA-damaging chemotherapeutics. Currently, they are designed to target the catalytic domain of PARP-1, the most studied member of the family, with a key role in the DNA-damage repair process. Because PARP inhibitors are substrate (NAD) competitors, there is a need for a deeper understanding of their cross-reactivity. This is particularly relevant for PARP-2, the PARP-1 closest homologue, for which an embryonic lethal phenotype has been observed in double knockout mice. In this study, we describe the development and validation of binding assays based on fluorescence polarization (FP) and surface plasmon resonance (SPR) techniques. PARP-1, PARP-2, PARP-3, and TNKS-1 FP displacement assays are set up by employing ad hoc synthesized probes. These assays are suitable for high-throughput screening (HTS) and selectivity profiling, thus allowing the identification of NAD binding site selective inhibitors. The PARP-1 and PARP-2 complementary SPR binding assays confirm displacement data and the in-depth inhibitor characterization. Moreover, these formats have the potential to be broadly applicable to other members of the PARP family.
RegulationPharmacological HIF Activation Identifies HIF-Dependent and Independent Mechanisms of Investigating Mitochondrial Metabolism in Contracting HL-1 Cardiomyocytes Following Hypoxia and

Hypoxia is a consequence of cardiac disease and downregulates mitochondrial metabolism, yet the molecular mechanisms through which this occurs in the heart are incompletely characterized. Therefore, we aimed to use a contracting HL-1 cardiomyocyte model to investigate the effects of hypoxia on mitochondrial metabolism. Cells were exposed to hypoxia (2% O2) for 6, 12, 24, and 48 hours to characterize the metabolic response. Cells were subsequently treated with the hypoxia inducible factor (HIF)-activating compound, dimethyloxalylglycine (DMOG), to determine whether hypoxia-induced mitochondrial changes were HIF dependent or independent, and to assess the suitability of this cultured cardiac cell line for cardiovascular pharmacological studies. Hypoxic cells had increased glycolysis after 24 hours, with glucose transporter 1 and lactate levels increased 5-fold and 15-fold, respectively. After 24 hours of hypoxia, mitochondrial networks were more fragmented but there was no change in citrate synthase activity, indicating that mitochondrial content was unchanged. Cellular oxygen consumption was 30% lower, accompanied by decreases in the enzymatic activities of electron transport chain (ETC) complexes I and IV, and aconitase by 81%, 96%, and 72%, relative to controls. Pharmacological HIF activation with DMOG decreased cellular oxygen consumption by 43%, coincident with decreases in the activities of aconitase and complex I by 26% and 30%, indicating that these adaptations were HIF mediated. In contrast, the hypoxia-mediated decrease in complex IV activity was not replicated by DMOG treatment, suggesting HIF-independent regulation of this complex. In conclusion, 24 hours of hypoxia increased anaerobic glycolysis and decreased mitochondrial respiration, which was associated with changes in ETC and tricarboxylic acid cycle enzyme activities in contracting HL-1 cells. Pharmacological HIF activation in this cardiac cell line allowed both HIF-dependent and independent mitochondrial metabolic changes to be identified.
Robust Principal Component Analysis via Truncated Nuclear

Robust principal component analysis (RPCA) has been widely used to deal with high dimensional noisy data in many applications. Traditional RPCA approaches consider all the samples to recovery the low dimensionl subspace in a batch manner, which incur expensive storage cost and fail to update the low dimensional subspace efficiently for stream data. Thus it is urgent to develop online RPCA methods. In this paper, we propose a novel online RPCA algorithm by adopting a recently proposed truncated nuclear norm as a tighter approximation of low rank constraint. Then we decompose the objective function as a summation of sample-wise cost. And we design an efficient alternating optimization algorithm in an online manner. Experimental results show that our proposed method can achieve more accurate low dimensional subspace estimation performance compared with state-of-the-art online RPCA algorithms.
Vietnam’s Accession to the WTO: Lessons from Past Trade Agreements

This paper examines Vietnam’s experience with bilateral trade agreements and compares subsequent outcomes with predictions from existing computable general equilibrium (CGE) models. Those model based assessments have greatly underestimated the impact of past agreements. Tariff reform is not the main factor driving economic adjustments, and market imperfections mean there is potential for greater output and trade expansion. The key questions to ask in future research are what critical new institutional reforms WTO accession will bring, and what incentives will be put in place to determine the evolution of investment by sector.
Root-MUSIC Time Delay Estimation Based on Propagator Method

This paper presents a new root multiple signal classification (Root-MUSIC) time delay estimation method based on the concept of well known propagator method (PM). The PM does not need the eigenvalue decomposition whose computational complexity is high. This method has great performance of time delay estimation under the condition of high signal to noise ratio (SNR) and need spectral peak searching whose computational complexity is very high. To address those issues, the new method is proposed. The proposed algorithm has high resolution capabilities and has lower computational complexity than conventional PM. Its computational complexity significantly reduces by using the method of finding the root of polynomial instead of the spectral peak searching and the eigenvalue decomposition. Theoretical analysis and computer simulation results show that the proposed method is effective.
Evaluating the Construct Validity of Final Test of Grade Three of Junior High School in Iran

Construct validity “is a fundamental requirement for the effective operation of any assessment system that everybody involved in interpreting assessment results shares at least a basic understanding of the construct or constructs involved” (Green, 2014, p. 81). The aim of the present study was to evaluate the construct validity of final test of grade three of junior high school used in Fars Province, Iran. To achieve this objective 35 EFL teachers teaching English at public schools participated. Also, 50 students’ final test sheets in 2016-2017 school year were selected. One instrument was a 17-items researcher-made checklist to evaluate the construct validity by the teachers. Data obtained from this instrument were analyzed using descriptive statistics i.e. Mean and Standard Deviation. The results revealed that participants evaluated 53% of the construct of the test as valid. It means that they evaluated the construct validity of the test as fair, but not strong. The second instrument was the students’ final test sheets. The scores were analyzed using item facility (If) and item discrimination (ID) to find the acceptable items. 36.66% of items were acceptable in the sample of the study. Another analysis refers to correlation coefficient among total score and test parts and, also, among test parts themselves. The correlation among test score and test parts was very strong (r>0.8), and it was strong among test parts (r>0.6). Because the test framework is recommended by Curriculum and Textbooks Development Office of Iranian Ministry of Education, the results of this study can be used to enhance construct validity of national-wide tests.
Three Dimensional Secondary Vortexes in the Wake past a Circular Cylinder Using High Order Scheme

Introduction While the research for flow over a circular cylinder has been actively carried out up to the present, it has been known that the flow has not been clarified even now. Various complex flow and aero-acoustic characteristics exist around a circular cylinder such as flow separation, wake and pressure wave propagation [1]. The flow is symmetric with respect to the front and back if the Reynolds Number is less than 45. If the Reynolds Number is higher, vortex shedding will occur in the rear of cylinder because abnormal flow will occur. This vortex shedding becomes the main cause of vibration, noise and periodic lift and drag on the cylinder. Norberg[1] compiled the theoretical, experimental and numerical research results for a circular cylinder flow and analyzed the flow characteristic according to the Reynolds number. He showed that there was a considerable difference in characteristics between experimental and numerical analysis results up to the present. As the Reynolds number increases, three dimensional instability increases in the wakes, and this becomes the cause for increase in lift, drag and Reynolds stress. Because of the pressure change, Karman vortex will occur periodically and the periodic characteristic of lift and drag will be generated [2]. Williamson [3] showed that two dimensional vortex shedding occurs when the Reynolds Number is less than 180. When it is greater than this value, he showed that unstable three dimensional vortex shedding will appear as Mode A and Mode B form. In this paper, research was carried out for wake flow over a circular cylinders by using high order, high resolution techniques that are used in two dimensional aeroacoustic analysis[4]. While theoretical equations and experiments were mainly used for the analysis of aeroacoustic in the past [5], a variety of research is being carried out for the mutual interference between flow and acoustics by using high order computation techniques in recent times. Numerical instability occurs if nonlinear discontinuous wave is computed with a high order, high resolution technique. The artificial dissipation model proposed by Kim&Lee [6] was applied to three dimensional flows to remove the numerical instability. Numerical analysis using the high order technique requires a long computation time and a large memory capacity. Therefore, in order to improve the processing time, OpenMP parallel
Single-Case Intervention Research Design Standards

In an effort to responsibly incorporate evidence based on single-case designs (SCDs) into the What Works Clearinghouse (WWC) evidence base, the WWC assembled a panel of individuals with expertise in quantitative methods and SCD methodology to draft SCD standards. In this article, the panel provides an overview of the SCD standards recommended by the panel (henceforth referred to as the Standards) and adopted in Version 1.0 of the WWC’s official pilot standards. The Standards are sequentially applied to research studies that incorporate SCDs. The design standards focus on the methodological soundness of SCDs, whereby reviewers assign the categories of Meets Standards, Meets Standards With Reservations, and Does Not Meet Standards to each study. Evidence criteria focus on the credibility of the reported evidence, whereby the outcome measures that meet the design standards (with or without reservations) are examined by reviewers trained in visual analysis and categorized as demonstrating Strong Evidence, Moderate Evidence, or No Evidence. An illustration of an actual research application of the Standards is provided. Issues that the panel did not address are presented as priorities for future consideration. Implications for research and the evidence-based practice movement in psychology and education are discussed. The WWC’s Version 1.0 SCD standards are currently being piloted in systematic reviews conducted by the WWC. This document reflects the initial standards recommended by the authors as well as the underlying rationale for those standards. It should be noted that the WWC may revise the Version 1.0 standards based on the results of the pilot; future versions of the WWC standards can be found at http://www.whatworks. ed.gov.