Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization of Single Particles in Urban Atmospheric Aerosols Over Nagoya Based on Mass Spectral Analysis

Mass spectral analysis of single aerosol particles was performed using a high-resolution time-of-flight aerosol mass spectrometer (HR-ToF-AMS) in the urban area of Nagoya, Japan, for five days in the autumn of 2010. An ion-series analysis was applied to the single-particle mass spectra; the sum of the masses at Δ of 1, 3, 4, and 5 divided by the total mass of organics (fΔ1,3-5) was used as an indicator of the degree of oxygenation of the organics. The organic mass fraction (Forg) and fΔ1,3-5 of single particles varied substantially, and the results for the entire period indicate that two groups of particles with high and low fΔ1,3-5 were present. The organics in particles with high Forg were less oxygenated, whereas those with low Forg were more oxygenated; these different particles were associated with hydrocarbon-like organic aerosols (HOA) and low-volatility oxygenated organic aerosols (LV-OOA), respectively, based on the PMF analysis of the MS mode data. The size distributions of the two types of particles overlapped substantially. The degree of the overlap depends on the equivalent particle diameter used, indicating the importance of single-particle analysis in understanding the size-composition relationship in detail. Alteration of the aerosol mixing state was clearly indicated by the changes in fΔ1,3-5 and Forg; the homogeneous conditions changed to externally mixed conditions from the evening until noon of the next day. Possible causes of this alteration include the condensation of oxygenated organics and ammonium nitrate onto pre-existing particles. This study demonstrated the usefulness of single-particle analysis based on electron-ionization aerosol mass spectrometry. Copyright 2015 American Association for Aerosol Research
How sandbag-able are concussion sideline assessments? A close look at eye movements to uncover strategies

ABSTRACT Background: Sideline diagnostic tests for concussion are vulnerable to volitional poor performance (“sandbagging”) on baseline assessments, motivated by desire to subvert concussion detection and potential removal from play. We investigated eye movements during sandbagging versus best effort on the King-Devick (KD) test, a rapid automatized naming (RAN) task. Methods: Participants performed KD testing during oculography following instructions to sandbag or give best effort. Results: Twenty healthy participants without concussion history were included (mean age 27 ± 8 years). Sandbagging resulted in longer test times (89.6 ± 39.2 s vs 48.2 ± 8.5 s, p < .001), longer inter-saccadic intervals (459.5 ± 125.4 ms vs 311.2 ± 79.1 ms, p < .001) and greater numbers of saccades (171.4 ± 47 vs 138 ± 24.2, p < .001) and reverse saccades (wrong direction for reading) (21.2% vs 11.3%, p < .001). Sandbagging was detectable using a logistic model with KD times as the only predictor, though more robustly detectable using eye movement metrics. Conclusions: KD sandbagging results in eye movement differences that are detectable by eye movement recordings and suggest an invalid test score. Objective eye movement recording during the KD test shows promise for distinguishing between best effort and post-injury performance, as well as for identifying sandbagging red flags.
Evaluation of drug susceptibility profile of Mycobacterium tuberculosis Lineage 1 from Brazil based on whole genome sequencing and phenotypic methods

BACKGROUND The evaluation of procedures for drug susceptibility prediction of Mycobacterium tuberculosis based on genomic data against the conventional reference method test based on culture is realistic considering the scenario of growing number of tools proposals based on whole-genome sequences (WGS). OBJECTIVES This study aimed to evaluate drug susceptibility testing (DST) outcome based on WGS tools and the phenotypic methods performed on isolates of M. tuberculosis Lineage 1 from the state of Pará, Brazil, generally associated with low levels of drug resistance. METHODOLOGY Culture based DST was performed using the Proportion Method in Löwenstein-Jensen medium on 71 isolates that had been submitted to WGS. We analysed the seven main genome sequence-based tools for resistance and lineage prediction applied to M. tuberculosis and for comparison evaluation we have used the Kappa concordance test. FINDINGS When comparing the WGS-based tools against the DST, we observed the highest level of agreement using TB-profiler. Among the tools, TB-profiler, KvarQ and Mykrobe were those which identified the largest number of TB-MDR cases. Comparing the four most sensitive tools regarding resistance prediction, agreement was observed for 43 genomes. MAIN CONCLUSIONS Drug resistance profiling using next-generation sequencing offers rapid assessment of resistance-associated mutations, therefore facilitating rapid access to effective treatment.
A Validated, Automated, 3-Dimensional Method to Reliably Measure Tibial Torsion

Background: Tibial torsion is a twist in the tibia measured as an angle between a proximal axis line and a distal axis line. Abnormal torsion has been associated with a variety of painful clinical syndromes of the lower limb. Measurements of normal tibial torsion reported by different authors vary by 100% (ranging from 20° to 42°), making it impossible to determine normal and pathological levels. Purpose: To address the problem of unreliable measurements, this study was conducted to define an automated, validated computer method to calculate tibial torsion. Reliability was compared with current clinical methods. The difference between measurements of torsion generated from computed tomography (CT) and magnetic resonance imaging (MRI) scans of the same bone, and between males and females, was assessed. Study Design: Controlled laboratory study. Methods: Previous methods of analyzing tibial torsion were reviewed, and limitations were identified. An automated measurement method to address these limitations was defined. A total of 56 cadaveric and patient tibiae (mean ± SD age, 37 ± 15 years; range, 17-71 years; 28 female) underwent CT scanning, and 3 blinded assessors made torsion measurements by applying 2 current clinical methods and the automated method defined in the present article. Intraclass correlation coefficient (ICC) values were calculated. Further, 12 cadaveric tibiae were scanned by MRI, stripped of tissue, and measured using a structured light (SL) scanner. Differences between torsion values obtained from CT, SL, and MRI scans, and between males and females, were compared using t tests. SPSS was used for all statistical analysis. Results: When the automated method was used, the tibiae had a mean external torsion of 29°± 11° (range, 9°-65). Automated torsion assessment had excellent reliability (ICC, 1), whereas current methods had good reliability (ICC, 0.78-0.81). No significant difference was found between the torsion values calculated from SL and CT (P = .802), SL and MRI (P = .708), or MRI and CT scans (P = .826). Conclusion: The use of software to automatically perform measurements ensures consistency, time efficiency, validity, and accuracy not possible with manual measurements, which are dependent on assessor experience. Clinical Relevance: We recommend that this method be adopted in clinical practice to establish databases of normal and pathological tibial torsion reference values and ultimately guide management of related conditions.
Dual and Opposite Costimulatory Targeting with a Novel Human Fusion Recombinant Protein Effectively Prevents Renal Warm Ischemia Reperfusion Injury and Allograft Rejection in Murine Models

Many studies have shown both the CD28—D80/86 costimulatory pathway and the PD-1—PD-L1/L2 coinhibitory pathway to be important signals in modulating or decreasing the inflammatory profile in ischemia-reperfusion injury (IRI) or in a solid organ transplant setting. The importance of these two opposing pathways and their potential synergistic effect led our group to design a human fusion recombinant protein with CTLA4 and PD-L2 domains named HYBRI. The objective of our study was to determine the HYBRI binding to the postulated ligands of CTLA4 (CD80) and PD-L2 (PD-1) using the Surface Plasmon Resonance technique and to evaluate the in vivo HYBRI effects on two representative kidney inflammatory models—rat renal IRI and allogeneic kidney transplant. The Surface Plasmon Resonance assay demonstrated the avidity and binding of HYBRI to its targets. HYBRI treatment in the models exerted a high functional and morphological improvement. HYBRI produced a significant amelioration of renal function on day one and two after bilateral warm ischemia and on days seven and nine after transplant, clearly prolonging the animal survival in a life-sustaining renal allograft model. In both models, a significant reduction in histological damage and CD3 and CD68 infiltrating cells was observed. HYBRI decreased the circulating inflammatory cytokines and enriched the FoxP3 peripheral circulating, apart from reducing renal inflammation. In conclusion, the dual and opposite costimulatory targeting with that novel protein offers a good microenvironment profile to protect the ischemic process in the kidney and to prevent the kidney rejection, increasing the animal’s chances of survival. HYBRI largely prevents the progression of inflammation in these rat models.
Bereavement After Patient Deaths Among Chinese Physicians and Nurses: A Qualitative Description Study

In order to achieve an in-depth understanding of professional caregivers’ experiences of bereavement after patient deaths in Mainland China, qualitative description was employed. 24 physicians and nurses from hospitals in Nanjing, China, participated in one-to-one, semi-structured interviews. Thematic analysis was adopted for data analysis. Five themes were generated: the nature of professional bereavement experiences, the meaning of patient deaths, immediate bereavement reactions, long-term changes, and coping strategies. Each theme included personal and professional dimensions. Professional bereavement experiences in Mainland China were found to be influenced by workplace violence against professional caregivers, traditional Chinese medical ethics, the strong death taboo, and inadequacies of the healthcare system. Professional bereavement experiences are meaning-driven, comprehensive, and usually disenfranchised. They involve multidimensional reactions and have both short-term and long-lasting, both event-specific and accumulated impacts. Cultural and systemic factors could shape professional bereavement experiences.
STRUCTURE OF NEW ANTHOCYANIN-DERIVED WINE PIGMENTS

Two new malvidin-derived pigments, referred to as A and B, were detected in red wine made from Vitis vinifera grapes (var. Carignane) and characterised. The results reported herein indicate that they are formed by covalent binding of major wine anthocyanins [malvidin 3-monoglucoside and malvidin 3-(6-p-coumaroyl)monoglucoside] with 4-vinylphenol. Synthetic products obtained by reaction between these reagents were shown to be identical with the natural compounds on the basis of their UV-visible, mass and 1H NMR spectra. Their formation involves cyclisation between C-4 and the hydroxy group at C-5 of the original flavylium moiety and the vinylphenol double bond. Subsequent oxidation leads to pigment A or B. Their structure can yield two flavylium mesomeric forms, one corresponding to the malvidin type and the other to the pelargonidin type. The pigments' colour suggests that the latter is the predominant form under our conditions.
Surface chemistry of deinked pulps as analysed by XPS and ToF‐SIMS

The surface chemistry of recycled deinked pulps made from old newspaper (ONP) and mixed office waste (MOW) was investigated by XPS and time‐of‐flight secondary ion mass spectrometry (ToF‐SIMS). The short and the long fibre fractions of the pulps were separated and their differences in surface chemistry were assessed. The amount of surface anionic groups (SAG) and the surface coverage by carbohydrates, lignin and extractives were calculated from the XPS measurements. Metal traces were observed on feed pulps and the fines fractions of both ONP and MOW, some of them exposed after extraction. Only fines of ONP showed a quantifiable amount of surface extractives. The amount of surface lignin did not differ significantly between the ONP fractions. The method presented high values of surface lignin on MOW, especially fines fraction, which was considered, in fact, a measure of other surface contamination. There were no remarkable differences between the SAGs in the different fractions. Residual chemicals from paper converting, printing and deinking were detected on the fibre surfaces by ToF‐SIMS spectrometry. The distributions of trace metals (e.g. Fe, Al and Mg), pulp components and some common contaminants were assessed using ToF‐SIMS imaging. It was discovered that the fibre surfaces were covered by patchy ink residuals at raster sizes of 200 µm × 200 µm. A uniform layer of siloxanes and phthalates was also detected on every sample. The residual paper and printing chemicals can affect interactions in papermaking and reduce the fibre‐to‐fibre bonds in the recycled paper. Copyright © 2010 John Wiley & Sons, Ltd.
Trends in Technology Usage for Parkinson's Disease Assessment: A Systematic Review

Parkinson's disease (PD) is a neurological disorder with complicated and disabling motor and non-motor symptoms. The complexity of PD pathology is amplified further due to its dependency on patient diaries and the neurologist's subjective assessment of clinical scales. This challenge can be addressed by the advances in mobile technology, which can enable objective, accurate, and continuous patient monitoring. Indeed, a significant amount of recent work explores new cost-effective and subjective assessment methods of PD symptoms. For example, smart technologies, such as wearable sensors, have been used to analyze a PD patients' symptoms to assess their disease progression and even to detect signs in their nascent stage for early diagnosis of PD. This review focuses on the use of modern wearable and mobile equipment for PD applications in the last decade. Four significant fields of research were identified: Assistance to Diagnosis, Prognosis or Monitoring of Symptoms and their Severity, Predicting Response to Treatment, and Assistance to Therapy or Rehabilitation. This study starts with 31,940 articles published between January 2008 and December 2019 in the following four databases: Pubmed Central, Science Direct, IEEE Xplore and MDPI. A total of 976 papers are manually investigated and included in this review after removing unrelated articles, duplicate entries, publications in languages other than English, and other articles that did not fulfill the selection criteria. Our analysis shows that the numbers of published papers every year has increased at a constant rate from 2008 to 2015, while the rate of increase has significantly grown from 2016 to 2019. Majority of the papers (62%) were published in the last four years, and 21% papers in just 2019. In terms of the symptoms, gait and tremor are two major ones that researchers have focused on. The trend shows the growing interest in assessing Parkinson's Disease with wearable devices in the last decade, particularly in the last 4 years. Our automated script makes the review easily reproducible for publications published in the future.
Estimation of Sexual Maturity Based on Morphometrics of Genital Organs in Male Northern Fur Seals, Callorhinus ursinus

Abstract. It's not always possible to obtain samples from dead male pinnipeds that are fresh enough to determine the histological characteristics of spermatogenesis and their stage of sexual maturity. We propose that the morphometrics of genital organs of northern fur seals, Callorhinus ursinus, can be used as a new indicator of sexual maturity. We analyzed data from collected records of male fur seals around Hokkaido during 2011–2017 to examine morphometrics of genital organs and their stage in histological characteristics of spermatogenesis. First, we investigated ontogenetic and seasonal variation in three genital organs: testes, epididymides, and bacula. Second, we classified the stages of histological characteristics of spermatogenesis into three groups (Stage A–C) using non-linear discriminant analysis, based on the stage in histological characteristics of spermatogenesis determined by histological observation of seminiferous tubules. Testicular size, testicular mass, and epididymal mass showed seasonal variation associated with spermatogenesis. From our analysis, the stage in histological characteristics of spermatogenesis could be estimated using testicular mass with high accuracy of predicting spermatogenesis. And measurement of baculum was suggested to be an indicator of predicting sexual maturity. We conclude that this simple estimation may be used to determine sexual maturity based on individual growth patterns.
Civic duty and career outcomes in a career-based system: a two-wave, multisource study

Abstract Since research on career trajectories in the public sector is rare, little is known about who continues a public-sector career and is promoted to higher-level positions. Building on social exchange theory, this study examines whether civic duty in t1 prevents public servants from leaving and is reciprocated in terms of promotions, how this relationship is mediated by career commitment, and how promotions impact career commitment in t2. We gathered responses from 1,490 members of the Federal Armed Forces Germany in a two-wave survey and matched them with objective data on turnover and promotions. The results show that civic duty has no direct effect on turnover and only slightly increases the likelihood of promotions. This may explain why promotions have no effect on career commitment in t2. We draw conclusions regarding retention and career management and discuss the implications in light of the criticism of career-based systems in the public service.
hMSC interaction with PCL and PCL/gelatin platforms: A comparative study on films and electrospun membranes

Polycaprolactone (PCL) and PCL/gelatin membranes and films were fabricated by electrospinning and solvent casting. A systematic analysis of the morphology evolution, as degradation occurred, was made to separate the contribution of fiber nanotexture and gelatin biochemical signal on cell adhesion and proliferation. Field emission scanning electron microscope was used to assess the contribution of platform architecture on the gelatin degradation by the morphological changes that occurred at different times. The evaluation of human mesenchymal stem cells’ biocompatibility confirmed the role of architecture and chemical composition on cell response. The nanostructured surfaces positively affected the cell recognition by increasing the surface area. The gelatin embedded in the PCL matrix of the nanofibers improved the cell/material interaction and provided support to the proliferation. The PCL/gelatin electrospun membranes showed an increase in mineralization when conditioned in osteogenic medium; this system has promise for long-term in vitro investigations of bone regeneration.
Evolution of Metal-Trifluoroacetate Precursors in the Thermal Decomposition toward High-Performance YBa2Cu3O7 Superconducting Films

A thorough analytical study on the thermal decomposition evolution of the metal-trifluoroacetate precursor toward high-performance YBa2Cu3O7 superconducting films is presented. Evolved gas analysis (EGA), using Fourier transform infrared spectroscopy (FTIR) and mass spectrometry (MS), as well as X-ray diffraction (XRD), was performed to determine the complete chemical decomposition reaction of the metal-trifluoroacetate precursors. It is noteworthy that, contrary to what had been previously described, HF was not detected in the released gas. Moreover, we present new processing conditions that successfully reduced and even eliminated the undesirable porosity of the pyrolyzed films. Focused-ion-beam (FIB) studies demonstrated that the formation of pores was related to a fast escape of the released gas during precursor decomposition. The oxygen partial pressure was determined to be a key parameter to control both the kinetics and thermodynamics of the decomposition reaction and, hence, the porosity. This is .
Direct Field Effect of Neighboring Cell Transistor on Cell-to-Cell Interference of nand Flash Cell Arrays

We introduce the concept of the direct field effect of a neighboring cell transistor on the cell-to-cell interference of NAND Flash cell memory. As the cell size reduces to below 50 nm, the electric field of the adjacent cell transistor directly influences the shallow-trench isolation corner of a selected cell transistor, provoking a significant cell V TH shift. In a way different from how conventional parasitic capacitance-coupling effect alters only the floating gate voltage, the direct field effect changes the cell V TH intrinsically and provokes an intense V TH shift, particularly in word-line direction (x-direction), due to severe boron segregation on a channel edge. In a 45-nm design-rule nand Flash cell, this effect provokes 0.67 V of the V TH shift in the x-direction, while a conventional capacitance-coupling effect yields 0.28 V.
Prevalent Synergy and Antagonism Among Antibiotics and Biocides in Pseudomonas aeruginosa

Antimicrobials can exert specific physiological effects when used in combination that are different from those when applied alone. While combination effects have been extensively mapped for antibiotic-antibiotic combinations, the combination effects of antibiotics with antimicrobials used as biocides or antiseptics have not been systematically investigated. Here, we investigated the effects of combinations of antibiotics (meropenem, gentamicin, and ciprofloxacin) and substances used as biocides or antiseptics [octenidine, benzalkonium chloride, cetrimonium bromide, chlorhexidine, Povidone-iodine, silver nitrate (AgNO3), and Ag-nanoparticles] on the planktonic growth rate of Pseudomonas aeruginosa. Combination effects were investigated in growth experiments in microtiter plates at different concentrations and the Bliss interaction scores were calculated. Among the 21 screened combinations, we find prevalent combination effects with synergy occurring six times and antagonism occurring 10 times. The effects are specific to the antibiotic-biocide combination with meropenem showing a tendency for antagonism with biocides (6 of 7), while gentamicin has a tendency for synergy (5 of 7). In conclusion, antibiotics and biocides or antiseptics exert physiological combination effects on the pathogen P. aeruginosa. These effects have consequences for the efficacy of both types of substances and potentially for the selection of antimicrobial resistant strains in clinical applications with combined exposure (e.g., wound care and coated biomaterials).
Initiation Criteria of High Explosives at different projectile or jet densities

Test results of initiation threshold values with tungsten spheres of different diameters d and Lexan spheres of 76 mm diameter can be very well described by the u2d-Held-criterion where u is the cratering velocity or . For covered Composition B the initiation threshold value is 23 mm3/μs2. This value fits also shaped charge tests where the high explosive charge is also in a covered arrangement.