Miracle-dz/UniFAR-FTUs huggingface dataset:
Pattern Classification of Autistic Individuals using Brain Imaging Data: A Review

— Autism is a neuro-developmental disorder characterized by impairments in social interaction and communications along the presence of unusual behaviours and interests. It is seen in children below the age of five and is usually identified through behavioural symptoms exhibited by them. Functional magnetic resonance imaging (fMRI), since its development has become one of the leading research tools for mapping brain activity. Machine learning techniques like support vector machines and neural network classifiers can be adopted for the classification of autistic from the controls in the given fMRI data. A review on different approaches to bring out pattern classification of autistic persons using brain imaging data would throw some light on the current research outputs and further bring out areas in which better accuracy can be achieved.
Properties of voltage-gated Ca 2 1 channels in rabbit ventricular myocytes expressing Ca 2 1 channel a 1E cDNA

Properties of voltage-gated Ca 2 1 channels in rabbit ventricular myocytes expressing Ca 2 1 channel a 1E cDNA. Am J Physiol Cell Physiol 280: C175–C182, 2001. —Using the whole-cell patch-clamp technique, we have studied the properties of a 1E Ca 2 1 channel transfected in cardiac myocytes. We have also investigated the effect of foreign gene expression on the intrinsic L-type current ( I Ca,L ). Expression of green ﬂuorescent protein sig- niﬁcantly decreased the I Ca,L . By contrast, expression of a 1E with b 2b and a 2 / d signiﬁcantly increased the total Ca 2 1 current, and in these cells a Ca 2 1 antagonist, PN-200-110 (PN), only partially blocked the current. The remaining PN-resistant current was abolished by the application of a low concentration of Ni 2 1 and was little affected by changing the charge carrier from Ca 2 1 to Ba 2 1 or by b -adrenergic stimu-lation. On the basis of its voltage range for activation, this channel was classiﬁed as a high-voltage activated channel. Thus the expression of a 1E did not generate T-like current in cardiac myocytes. On the other hand, expression of a 1E decreased I Ca,L and slowed the I Ca,L inactivation. This inacti- vation slowing was attenuated by the b 2b coexpression, suggesting that the a 1E may slow the inactivation of I Ca,L by scrambling with a 1C for intrinsic auxiliary b .
Identiﬁcation and localization of BK- (cid:1) subunits in the distal nephron of the mouse kidney

and localization of BK- (cid:1) subunits in the distal nephron of the mouse kidney. Am J Physiol Renal Physiol 293: F350–F359, 2007. doi:10.1152/ajprenal.00018. 2007. —Large-conductance, Ca 2 (cid:2) -activated K (cid:2) channels (BK), comprised of pore-forming (cid:3) - and accessory (cid:1) -subunits, secrete K (cid:2) in the distal nephron under high-ﬂow and high-K (cid:2) diet conditions. BK channels are detected by electrophysiology in many nephron segments; however, the accessory (cid:1) -subunit associated with these channels has not been determined. We performed RT-PCR, Western blotting, and immunohistochemical staining to determine whether BK- (cid:1) 1 is localized to the connecting tubule’s principal-like cells (CNT) or intercalated cells (ICs), and whether BK- (cid:1) 2-4 are present in other distal nephron segments. RT-PCR and Western blots revealed that the mouse kidney expresses BK- (cid:1) 1, BK- (cid:1) 2, and BK- (cid:1) 4. Available antibodies in con-junction with BK- (cid:1) 1 (cid:4) / (cid:4) and BK- (cid:1) 4 (cid:4) / (cid:4) mice allowed the speciﬁc localization of BK- (cid:1) 1 and BK- (cid:1) 4 in distal nephron segments. Immunohistochemical staining showed that BK- (cid:1) 1 is localized in the CNT but not ICs of the connecting tubule. The localization of BK- (cid:1) 4 was discerned using an anti-BK- (cid:1) 4 antibody on wild-type tissue and anti-GFP on GFP-replaced BK- (cid:1) 4 mouse (BK- (cid:1) 4 (cid:4) / (cid:4) ) tissue. Both antibodies (anti-BK- (cid:1) 4 and anti-GFP) localized BK- (cid:1) 4 to the thick ascending limb (TAL), distal convoluted tubule (DCT), and ICs of the distal nephron. It is concluded that BK- (cid:1) 1 is narrowly conﬁned to the apical membrane of CNTs in the mouse, whereas BK- (cid:1) 4 is expressed in the TAL, DCT, and ICs.
Type safety for substructural specifications: preliminary results (CMU-CS-10-134)

Substructural logics, such as linear logic and ordered logic, have an inherent notion of state and state change. This makes them a natural choice for developing logical frameworks that specify evolving stateful systems. Our previous work has shown that the so-called forward reasoning fragment of ordered linear logic can be used to give clear, concise, and modular specifications of stateful and concurrent features of programming languages in a style called Substructural Operational Semantics (SSOS). This report is discusses two new ideas. First, I discuss a re-orientation of existing logics and logical frameworks based on a presentation of logic as a state transition system. Second, utilizing this transition-based interpretation of logic, I present a safety proof for the SSOS specification of a simple sequential programming language, and discuss how that proof can be updated as the language is extended with parallel evaluation and exception handling. This report is derived from my thesis proposal [35], which was certified on July 7, 2010. This material is based upon work supported under a National Science Foundation Graduate Research Fellowship. Any opinions, findings, conclusions or recommendations expressed in this publication are those of the authors and do not necessarily reflect the views of the National Science Foundation.
Topological properties in topological insulators and superconductors

We give a self-contained and enriched review about topology properties in the rapidly growing field of topological states of matter (TSM). This review is mainly focus on the beautiful interplay of topology mathematics and condensed matter physics that issuing TSM. Fiber bundle theory is a powerful concept to describe the non-trivial topology properties underlying the physical system. So we briefly present some motivation of fiber bundle theory and following that several effective topological methods have been introduced to judge whether a fiber bundle is trivial or not. Next, we give some topological invariants that characterizes the non-trivial TSM in the non-interacting systems in all dimensions, which is called topological band theory. Following that, we review and generalize the topological response using topological field theory called Chern-Simons effective theory. Finally, the classification of free-fermion systems have been studied by loop space and K-theory.
Identiﬁcation of an Export Control Sequence and a Requirement for the KH Domains in ICP27 from Herpes Simplex Virus Type 1

The herpes simplex virus type 1 (HSV-1) immediate-early protein ICP27 is an RNA-binding protein that performs multiple functions required for the expression of HSV-1 genes during a productive infection. One essential function involves shuttling between the nucleus and the cytoplasm. Some of the domains identiﬁed in ICP27 include a leucine-rich nuclear export sequence (NES), a nuclear localization signal, three KH-like RNA-binding domains, and an RGG-box type RNA-binding motif. To study the contribution of two of the essential domains in ICP27 to HSV gene expression, we generated recombinant herpesviruses carrying deleterious mutations in the NES and KH domains of ICP27. To accomplish this, we fused the green ﬂuorescent protein (GFP) to ICP27 and utilized ﬂuorescence as a marker to isolate recombinant herpesviruses. Fusion of GFP to wild-type ICP27 did not disturb its localization or function or signiﬁcantly reduce virus yield. Analysis of HSV gene expression in cells infected with a recombinant virus carrying a point mutation in the ﬁrst KH-like RNA-binding domain revealed that nuclear export of ICP27 was not blocked, and the expression of only a subset of ICP27-dependent late genes was affected. These ﬁndings suggest that individual KH-like RNA-binding motifs in ICP27 may be involved in binding distinct RNAs. Analysis of recombinant viruses carrying a lethal mutation in the NES of ICP27 was not accomplished because this mutation results in a strong dominant-negative phenotype. Finally, we demonstrate that supplemented with 500 m g of G418 (Geneticin; Gibco BRL) per ml. The strain of wild-type HSV-1 used in this study was KOS 1.1A. The trans-placement vector, vBS D 27, contains a lacZ gene fragment in place of the se- quences encoding ICP27 and was described previously (50). vBSLG4 the ts HSV-1 mutant, (R480H), was described previously (12, 42, 50). The viruses vBSGFP27, vBSECS, and vBStsECS were generated from vBS D 27 by marker rescue for growth on Vero cells using a Bam HI-linearized fragment containing the a 27 allele from plasmids pBS7GFP27, pBSDD32AA, or pBSDD/ LG4, as previously described (50). The HSV-1 mutant virus vBSGFPKH1 car- rying a mutation in the KH1 domain was also generated by marker rescue using a Bam HI-linearized fragment containing the a 27 allele from plasmid pB- SGFP303 but was isolated on 2-2 cells using the ﬂuorescence of GFP as a marker for replicating virus. Unsuccessful attempts to isolate HSV-1 mutant viruses carrying a lethal mutation in the NES, vBSGFPNES, were performed as for vBSGFPKH1 using the linearized plasmid pBSGFPnes. All recombinant viruses were plaque puriﬁed three times.
Water Area Extraction from RGB Aerophotograph Based on Chromatic and Textural Analysis

When triangulating RGB aerophotograph, if automatically and randomly selected matching pass points unfortunately locates into water areas, these points, limited by their inaccuracy, will decrease the precision of triangulation. Therefore, extraction of water area beforehand is conducive to eliminate water falling pass points and guarantee the quality of aerotriangulation. A new methodology to extract water area from RGB aerophotograph is put forth in this paper. Procedure initiates by segmenting the whole aerophotograph into homogenous and united segments. Subsequently, compute chromatic and textural features of every segment and compare each segment’s features to sampled water segments’ features. Finally extract those segments whose chromatic and textural features are similar to sampled segments’ as water areas. This methodology has a relatively obvious merit in effectiveness and generality. Keywords—CIELAB; chromatic analysis; textual analysis; watershed segmentation; ISODATA
Human Memory Regulatory T Cells + HeliosCoexpression of TIGIT and FCRL3 Identifies

Two distinct subsets of CD4 + Foxp3 + regulatory T (Treg) cells have been described based on the differential expression of Helios, a transcription factor of the Ikaros family. Efforts to understand the origin and biological roles of these Treg populations in regulating immune responses have, however, been hindered by the lack of reliable surface markers to distinguish and isolate them for subsequent functional studies. Using a single-cell cloning strategy coupled with microarray analysis of different Treg functional subsets in humans, we identify the mRNA and protein expression of TIGIT and FCRL3 as a novel surface marker combination that distinguishes Helios + FOXP3 + from Helios 2 FOXP3 + memory cells. Unlike conventional markers that are modulated on conventional T cells upon activation, we show that the TIGIT/FCRL3 combination allows reliable identiﬁcation of Helios + Treg cells even in highly activated conditions in vitro as well as in PBMCs of autoimmune patients. We also demonstrate that the Helios 2 FOXP3 + Treg subpopulation harbors a larger proportion of nonsuppressive clones compared with the Helios + FOXP3 + cell subset, which is highly enriched for suppressive clones. Moreover, we ﬁnd that Helios 2 cells are exclusively respon-sible for the productions of the inﬂammatory cytokines IFN- g , IL-2, and IL-17 in FOXP3 + cells ex vivo, highlighting important functional differences between Helios + and Helios 2 Treg cells. Thus, we identify novel surface markers for the consistent identiﬁcation and isolation of Helios + and Helios 2 memory Treg cells in health and disease, and we further reveal functional differences between these two
A radiometric Bode's Law: Predictions for Uranus

The magnetospheres of three planets, Earth, Jupiter, and Saturn, are known to be sources of intense, nonthermal radio bursts. The emissions from these sources undergo pronounced long term intensity fluctuations that are caused by the solar wind interaction with the magnetosphere of each planet. Determinations by spacecraft of the low frequency radio spectra and radiation beam geometry now permit a reliable assessment of the overall efficiency of the solar wind in stimulating these emissions. Earlier estimates of how magnetospheric radio output scales with the solar wind energy input must be revised greatly, with the result that, while the efficiency is much lower than previously thought, it is remarkably uniform from planet to planet. The formulation of a radiometric Bode's Law from which a planet's magnetic moment is estimated from its radio emission output is presented. Applying the radiometric scaling law to Uranus, the low-frequency radio power is likely to be measured by the Voyager 2 spacecraft as it approaches this planet.
Assessment and Management of Older People in the General Hospital Setting Assessment and Management of Older People in the General Hospital Setting

Worldwide, populations are ageing. Older people, particularly centurions, represent the fastest growing sector and are counted as the success of the society. But not everyone ages successfully and enjoys good health. Many older people have multiple long-term medical, physical, mental, psychological and social problems. This can result in reduced quality of life, higher cost and poorer health outcome including increased mortality. Chronic diseases are associated with disability and low self-reported general health. In addition, physiological changes of ageing and consequent loss of functional reserve of the organ systems lead to the increased physical disability and dependency. Therefore, geriatric medicine could warrant a more holistic approach than general adult medicine. Nearly two-thirds of people admitted to hospital are over 65 years old and an increasing number are frail or have a diagnosis of dementia [1]. Our current training not only generates relatively low number of geriatricians but there also remains a huge need for better staff training and support to provide safe, holistic and dignified care. The cornerstone of modern geriatric medicine is the comprehensive geriatric assessment (CGA). This is defined as multidimensional, interdisciplinary diagnostic process that aims to determine a frail older person’s medical conditions, mental health, functional capability and social circumstances in order to develop a coordinated and integrated plan for treatment, rehabilitation and long-term follow-up [2]. All older people admitted to hospital with an acute medical illness, geriatric syndromes including falls, incontinence, delirium or immobility, unexplained functional dependency or need for rehabilitation warrant CGA. CGA could screen for treatable illnesses, establish the key diagnosis leading to hospital admission and formulate a rational therapeutic plan thus resulting in the improved outcome. This chapter starts with an introduction to the ageing nation and impact of ageing on hospitals. This will be followed by discussing physiological changes of ageing and the various components effectiveness CGA recommendations clinical care.
KEY BENEFITS OF ENTERPRISE RESOURCE PLANNING KEY BENEFITS OF ENTERPRISE RESOURCE PLANNING ADOPTION WITHIN SMALL FAMILY BUSINESSES: A ADOPTION WITHIN SMALL FAMILY BUSINESSES: A CONCEPTUAL FRAMEWORK (38) CONCEPTUAL FRAMEWORK (38)

This research mainly focused on the perceived benefits of ERP adoption for Small Family Businesses (SFB). In doing so, it explores some of the key benefits of an ERP system for SMEs. Through the exploration of the literature, a framework is constructed classifying the ERP benefits to SFBs, in that they are different to other businesses where ERP systems has historically been implemented. The literature also helps determine if there is a difference in ERP benefits owed to the family ownership and management of business that brings about unique characteristics. Finally, this research concludes that adopting an ERP system within a SFB environment could assist in them gaining competitive advantage by improving business performance and better managerial control. It could also aid the achievement of SFB’s succession goals.
Towards Perceived Space Representation using Brain Activity, Eye-Tracking and Terrestrial Laser Scanning

Deciphering how humans perceive physical spaces can lead to new reality capture methods and eventually replace measurement instruments like terrestrial laser scanners (TLSs). The current approach pursues this goal using non-invasive wearable sensors like Brain Computer Inter-faces (BCIs) and mobile eye-trackers. Work in progress from static experiments shows that positions of targets on a wall at 4 m can be determined with differences up to several dm and better w.r
PHYTOCONSTITUENTS AND IN VITRO ANTIOXIDANT STUDIES IN SOME COMMON FRUITS AVAILABLE IN MAIDUGURI, NIGERIA

The study was carried out to investigate the phytoconstituents, reducing power and total antioxidant capacity of some common fruits viz. Citrulis vulgaris, Cucumis melo, Cucumis sativus, Malus domestica, Ananas comosus, Musa paradisica, Psidium guajava, solanum melongena and citrus senensis in vitro by spectrophotometric method. The preliminary qualitative phytochemical analysis showed the presence of carbohydrates, proteins, amino acids, steroids, glycosides, flavonoids, tannins, and polyphenols in all the nine methanol fruit extracts. Psidium guajava, Ananas comosus, Citrus senensis, Malus domestica, Solanum melongena revealed the presence of Alkaloid whereas Alkaloid is not detected in the other fruits viz; Citrulis vulgaris, Cucumis melo, Cucumis sativus, Musa paradisiacal. Saponins is detected in Cucumis sativus and Cucumis melo only. The reducing power studies showed Psidium guajava to have the highest activity followed by Malus domestica>Citrus senensis melo>Cucumissativus>Musa paradisiaca. The antioxidant capacity studies showed Citrulis vulgaris to have the highest antioxidant capacity followed by Cucumis melo>Cucumissativus >Psidium guajava>Citrus senensis>Musa paradisiacal > Malus domestica >solanum melongena>Ananas comosus. This study revealed the potentials of these common fruits as natural antioxidants sources.
IntactParathyroidHormone:Performanceand ClinicalUtilityof an AutomatedAssay Based on High-PerformanceImmunoaffinityChromatographyand ChemiluminescenceDetection

The performance and clinical utility of an automated assay of intact parathyroid hormone (parathyrin, PTH) are evaluated. The method is based on the extraction of PTH from plasma by an HPLC column containing immobilized anti-(44-68 PTH) antibodies. The PTH retained is detected with a postcolumn reactor and use of anti-(1--34 PTh) chemiluminescent-labeled antibodies. The total cycle time of the assay is 6.5 mm per injection after a 1-h incubation.The lower limit of detection for PTH in a 66-pL plasma sample was 0.5 pmol/L based on peak heights and 0.2 pmol/L based on peak areas. Mean analytical recovery for PTH added to plasma was 97%. The within-day precisions (CVs) for 4.2 and 30 pmol/L PTH plasma samples were 9.2% and 5.6% and the day-to-day precisions were 10.3% and 5.7%, respectively. No significant interferences from 1-34,44-68, or 53-84 PTH fragments were noted, even at highly increased concentrations of fragments. The correlation of results with those of a manual assay of intact PTH was 0.97, and the results showed good agreement with disease state for patients with hypo- or hyperparathyroidism. The specificity of the assay for primary hyperparathyroldism was >95%. We discuss the advantages (speed and quality control)of this approach over current immunoassays and the potential use of this method for detecting other analytes.
Characterisation of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin’s lymphomas.

Despite the rapid and widespread integration of chimeric CD20 mAb, rituximab, into the management of non-Hodgkin’s lymphoma, its efficacy remains variable and often modest when used as a single agent. To develop more potent reagents, human immunoglobulin-transgenic mice were used to generate a panel of IgG1 κ CD20 mAb. All reagents bound strongly to CD20 + cells and recruited mononuclear cells for the lysis of malignant B cells. However, two mAb, 2F2 and 7D8, were exceptionally active in complement-dependent cytotoxcity (CDC), being able to lyse a range of rituximab resistant targets, such as CD20-low CLL, in the presence of human plasma or un-fractionated blood. Further analysis showed that 2F2 and 7D8, like rituximab, redistributed CD20 into Triton X-100 insoluble regions of the plasma membrane, but that they had markedly slower slow off-rates. To determine whether off-rate influenced CDC, a non-complement activating F(ab’) 2 anti-human kappa reagent was used. This reagent markedly slowed the off-rate of rituximab and increased its CDC activity to that of 2F2 and 7D8. Thus, with increasing evidence that mAb therapeutic activity in vivo depends on complement activation, these new CD20 reagents with their slow off-rates and increased potency in CDC hold considerable promise for improved clinical activity.
EFFECT OF SEA WATER AND MANNITOL ON TOTAL PHENOL ICS, FLAVONOID CONSTITUENTS AND ANTIOXIDANT ACTIVITY

: The effect of salinity alone or combined with mannitol on Kaff maryam ( Anastatica hierochuntica L.) sprouts cultivated for 2 and 4 months was investigated by analysis of total phenolics, flavonoid compounds and antioxidant activity. Salinity was induced by the irrigation with two concentrations of sea water; 50 mM (S1) and 150 mM (S2), while 125 Mm mannitol (M) was used as osmoregulatory substance and combined with the previously mentioned concentrations of sea water. The highest phenolic content was observed in S2 treatment (2 months old) (47 ± 0.133 mg GAE g -1 DWt.), while the highest flavonoids were observed through MS2 treatment (43.01 ± 0.28 mg QU g -1 DWt.). Otherwise, the antioxidant activity increased by increasing the total phenolics and flavonoid contents. Moreover, the accumulation of flavonoid compounds was attributed to an increase in the level of the major compounds; kaempferol 3- O -β-glucopyranoside, quercetin and quercetin 3- O -β-glucopyranoside. salinity, total phenolics, flavonoids, antioxidant activity.