Miracle-dz/UniFAR-FTUs huggingface dataset:
ASCENT: Active Supervision for Semi-Supervised Learning

Active learning algorithms attempt to overcome the labeling bottleneck by asking queries from large collection of unlabeled examples. Existing batch mode active learning algorithms suffer from three limitations: (1) The methods that are based on similarity function or optimizing certain diversity measurement, in which may lead to suboptimal performance and produce the selected set with redundant examples. (2) The models with assumption on data are hard in finding images that are both informative and representative. (3) The problem of noise labels has been an obstacle for algorithms. In this paper, we propose a novel active learning method that makes embeddings of labeled examples to those of unlabeled ones and back via deep neural networks. The active scheme makes correct association cycles that end up at the same class from that the association was started, which considers both the informativeness and representativeness of examples, as well as being robust to the noise labels. We apply our active learning method to semi-supervised classification and clustering. The submodular function is designed to reduce the redundancy of the selected examples. Specifically, we incorporate our batch mode active scheme into the classification approaches, in which the generalization ability is improved. For semi-supervised clustering, we try to use our active scheme for constraints to make fast convergence and perform better than unsupervised clustering. Finally, we apply our active learning method to data filtering. To validate the effectiveness of the proposed algorithms, extensive experiments are conducted on diversity benchmark datasets for different tasks, i.e., classification, clustering, and data filtering, and the experimental results demonstrate consistent and substantial improvements over the state-of-the-art approaches.
Human Papilloma Virus Infection and Vaccination: Pre-Post Intervention Analysis on Knowledge, Attitudes and Willingness to Vaccinate Among Preadolescents Attending Secondary Schools of Palermo, Sicily

In recent years, vaccination coverage rates against Human Papilloma Virus (HPV) in Europe have shown a decreasing trend and remain below the required standard. The present study aims to assess knowledge and attitudes regarding HPV infection and vaccination among a representative sample of preadolescents of Palermo, Italy. A survey was carried out throughout two questionnaires, before and after carrying out an educational intervention scheduled during school hours. A total of 1702 students attending first-grade secondary schools of the province of Palermo were enrolled (response rate 68.9%). Students attending third classes (adj OR = 1.18; CI 95% 1.03–1.36), being of higher socioeconomic status (adj OR = 1.35; CI 95% 1.05–1.73), who had previously received information about sexually transmitted diseases (STDs) at home (adj OR = 1.62; CI 95% 1.27–2.07) or at school (adj OR = 2.15; CI 95% 1.70–2.71) and who had ever heard in the past about HPV (adj OR = 1.80; CI 95% 1.42–2.29) showed a significantly higher baseline level of knowledge regarding HPV. Willingness to receive HPV vaccination, in a 10-point Likert scale, significantly increased between the pre- (8.51; SD ± 1.79) and post- (9.01 SD ± 1.52) intervention questionnaires (p < 0.001). A total of 188 out of 272 (69.1%) preadolescents attending five out eighteen schools involved in the project, who had not previously received the HPV vaccine, were vaccinated. During past years, education campaigns on HPV were mainly dedicated to adult women, excluding teenagers and omitting young males. It should therefore be of primary importance that school-based education and vaccination programmes be standardized.
Family functioning and negative emotions in older adults: the mediating role of self-integrity and the moderating role of self-stereotyping

Abstract Objectives The objective of this study was to examine a possible mediator role of self-integrity and a moderator role of self-stereotyping in the relationship between family functioning and negative emotions in older adults. Method A total of 1186 older adults participated in the current study. They completed measures related to family functioning, self-integrity, self-stereotyping, depression, anxiety, and loneliness. Results Older adults with family dysfunction experienced more negative emotions than those with healthy family functioning, a finding which could be explained by the levels of self-integrity. Older adults with high levels of self-stereotyping, unhealthy family functioning, and low self-integrity were significantly more likely to be depressed and anxious than those with low levels of self-stereotyping. Conclusion Family functioning negatively predicted negative emotions, self-integrity mediated the link between family functioning and negative emotions, and self-stereotyping moderated the direct and indirect effects of family functioning on depression and anxiety via self-integrity.
The Minimum Amount Of Observations Needed To Determine If the Universe Has A Mass Gap

Observations of gravitational waves, emitted from coalescing compact binaries allow physical parameters of the binary to be determined. The two purposes of this experiment is to use the mass parameters inferred from observations, such as the chirp mass, total mass, and the symmetric mass ratio (μ,M, η) to theoretically determine how many neutron star black hole binaries will need to be observed to determine if the universe has a mass gap between low mass black holes and high mass neutron stars or not, as well as, to see if the proposed method will be able to accurately identify differences among universes, such as metallicity and merger rates. Both problems are carried out by generating different universes and models of the universes, then comparing the models to all of the universes. As for the mass gap problem, the difference in universes lies with cutoff for component masses, generating mass gap and no gap distributions. The metallicity and merger rate problem is done by using the component mass distributions for NSBH systems that already take into account metallicity, merger rates and other parameters from S. Stevenson et al. (2015) [5]. Multivariate distributions are generated of chirp mass vs. total mass and chirp mass vs. the symmetric mass ratio which are compared between the mass gap and the no gap universe, keeping the types of distributions consistent. The Kolmogorov-Smirnov Test and the Anderson-Darling Test are utilized to determine how well the observed sample compares to the entire population of the theoretical universe. From these plots and tests it is estimated how many observations are needed to accurately model the universe and to make an accurate prediction of whether a mass gap exists or not.
Local Air Quality Issues and Research Priorities Through the Lenses of Chilean Experts: An Ontological Analysis

Air pollution problems can be large, complex, and ill‐structured. They can vary from location to location and combine many complex components: urban expansion, increasing vehicles and industrial emissions, biomass burning, geographic and meteorological conditions, cultural aspects, and economic effects. However, the existing research, accumulated knowledge, and local research priorities are spread over many disciplines and lack a systematic mapping to help manage and develop new strategies for researchers and policy makers. Ontological analysis can be used as a tool to capture this complexity through simple natural‐language descriptions and a structured terminology. We describe the development of an ontological framework for “Air Quality Management in Chile” and its application to evaluate the current state of the research. The process was based on focus groups and validated by a panel of multidisciplinary experts. We used the developed framework to highlight the topics that have been heavily emphasized, lightly emphasized, or overlooked in the Chilean research. The framework developed can help researchers, practitioners, and policy makers systematically navigate the domain and provide the opportunity to correct blind spots by enabling more informed hypotheses that deal with air quality issues at a national level. We believe that applying this same process to different countries will yield different results (due to differences in local knowledge and experience). The framework presented could be used to evaluate other important stakeholders (government, media, NGOs, etc.), which will provide a complete picture of how local societies deal with air quality issues at different levels. Additionally, local government institutions will benefit from this analysis by improving funding allocation and opening new research opportunities to improve the distribution of the local body of knowledge. Integr Environ Assess Manag 2021;17:273–281. © 2020 SETAC
Vanillic Acid Improves Comorbidity of Cancer and Obesity through STAT3 Regulation in High-Fat-Diet-Induced Obese and B16BL6 Melanoma-Injected Mice

Obesity is known to be associated with risk and aggressiveness of cancer. Melanoma, the most lethal type of skin cancer, is also closely related to the prevalence of obesity. In this study, we established a cancer–obesity comorbidity (COC) model to investigate the effects of vanillic acid (VA). After a five-week administration with a high-fat diet (HFD) to induce obesity, subcutaneous allograft of B16BL6 cells were followed, and VA was orally administrated for an additional two weeks. VA-fed mice showed significantly decreased body weight and white adipose tissue (WAT) weight, which were due to increased thermogenesis and AMPK activation in WATs. Growth of cancer was also suppressed. Mechanistic studies revealed increased apoptosis and autophagy markers by VA; however, caspase 3 was not involved. Since signal transducer and activator of transcription 3 (STAT3) is suggested as an important pathway linking obesity and cancer, we further investigated to find out if STAT3 phosphorylation was repressed by VA treatment, and this was again confirmed in a COC cell model of adipocyte conditioned medium-treated B16BL6 melanoma cells. Overall, our results show VA induces STAT3-mediated autophagy to inhibit cancer growth and thermogenesis to ameliorate obesity in COC. Based on these findings, we suggest VA as a candidate therapeutic agent for COC treatment.
Surprise me! On the impact of unexpected benefits on other-praising gratitude expressions

ABSTRACT Gratitude reinforces social bonds. This relationship-regulating function depends on whether and how it is expressed. People can express gratitude in different ways: Beneficiaries may emphasise how they profited from a benefit (self-benefiting) or focus on the benefactor's actions and characteristics related to it (other-praising). What underlies these expressive styles remains unclear. Based on findings that other-praising gratitude expressions have unique positive effects on interpersonal relationships, four studies (N = 1,188) investigated a novel antecedent of these expressions: unexpectedness of the benefit. In Study 1, we content-coded participants’ thank-you notes for an actual Christmas present. Path modelling revealed that unexpectedness of the benefit predicted other-praising, whereas happiness with the present predicted self-benefiting. These results were robust to relevant covariates and mirrored by participants’ self-reported self-benefiting and other-praising intentions. Studies 2–4 (preregistered) investigated samples from two different populations and experimentally manipulated (un)expectedness of recalled or imagined benefits. Given mixed experimental results, we conducted an internal meta-analysis. Across experimental studies, unexpected benefits increased other-praising, albeit weakly so, but not self-benefiting. In addition, the effect of unexpectedness on other-praising was significantly different from that on self-benefiting. We discuss potential processes and moderators of the effect of unexpected benefits on gratitude expressions.
Using Automatic Assessment of Speech Production to Predict Current and Future Cognitive Function in Older Adults

Neurodegenerative conditions like Alzheimer disease affect millions and have no known cure, making early detection important. In addition to memory impairments, dementia causes substantial changes in speech production, particularly lexical-semantic characteristics. Existing clinical tools for detecting change often require considerable expertise or time, and efficient methods for identifying persons at risk are needed. This study examined whether early stages of cognitive decline can be identified using an automated calculation of lexical-semantic features of participants’ spontaneous speech. Unimpaired or mildly impaired older adults (N = 39, mean 81 years old) produced several monologues (picture descriptions and expository descriptions) and completed a neuropsychological battery, including the Modified Mini-Mental State Exam. Most participants (N = 30) returned one year later for follow-up. Lexical-semantic features of participants’ speech (particularly lexical frequency) were significantly correlated with cognitive status at the same visit and also with cognitive status one year in the future. Thus, automated analysis of speech production is closely associated with current and future cognitive test performance and could provide a novel, scalable method for longitudinal tracking of cognitive health.
CHOP and c-JUN up-regulate the mutant Z α1-antitrypsin, exacerbating its aggregation and liver proteotoxicity

α1-Antitrypsin (AAT) encoded by the SERPINA1 gene is an acute-phase protein synthesized in the liver and secreted into the circulation. Its primary role is to protect lung tissue by inhibiting neutrophil elastase. The Z allele of SERPINA1 encodes a mutant AAT, named ATZ, that changes the protein structure and leads to its misfolding and polymerization, which cause endoplasmic reticulum (ER) stress and liver disease through a gain-of-function toxic mechanism. Hepatic retention of ATZ results in deficiency of one of the most important circulating proteinase inhibitors and predisposes to early-onset emphysema through a loss-of-function mechanism. The pathogenetic mechanisms underlying the liver disease are not completely understood. C/EBP-homologous protein (CHOP), a transcription factor induced by ER stress, was found among the most up-regulated genes in livers of PiZ mice that express ATZ and in human livers of patients homozygous for the Z allele. Compared with controls, juvenile PiZ/Chop−/− mice showed reduced hepatic ATZ and a transcriptional response indicative of decreased ER stress by RNA-Seq analysis. Livers of PiZ/Chop−/− mice also showed reduced SERPINA1 mRNA levels. By chromatin immunoprecipitations and luciferase reporter–based transfection assays, CHOP was found to up-regulate SERPINA1 cooperating with c-JUN, which was previously shown to up-regulate SERPINA1, thus aggravating hepatic accumulation of ATZ. Increased CHOP levels were detected in diseased livers of children homozygous for the Z allele. In summary, CHOP and c-JUN up-regulate SERPINA1 transcription and play an important role in hepatic disease by increasing the burden of proteotoxic ATZ, particularly in the pediatric population.
Assembly of alternative prothrombinase by extracellular histones initiate and disseminate intravascular coagulation.

Thrombin generation is pivotal to both physiological blood clot formation and pathological development of disseminated intravascular coagulation (DIC). In critical illness, extensive cell damage can release histones into the circulation, which can increase thrombin generation and cause DIC, but the molecular mechanism is not clear. Typically, thrombin is generated by the prothrombinase complex, comprising activated factor X (FXa), activated co-factor V (FVa) and phospholipids to cleave prothrombin in the presence of calcium. In this study, we found that in the presence of extracellular histones, an alternative prothrombinase could form without FVa and phospholipids. Histones directly bind to prothrombin fragments F1 and F2 specifically, to facilitate FXa cleavage of prothrombin to release active thrombin, unlike FVa which requires phospholipid surfaces to anchor the classical prothrombinase complex. In vivo, histone infusion into mice induced DIC, which was significantly abrogated when prothrombin fragments F1+F2 were infused prior to histones, to act as decoy. In a cohort of intensive care unit (ICU) patients with sepsis (n=144), circulating histone levels were significantly elevated in patients with DIC. These data suggest that histone-induced alternative prothrombinase without phospholipid anchorage may disseminate intravascular coagulation, and reveal a new molecular mechanism of thrombin generation and DIC development. In addition, histones significantly reduced the requirement for FXa in the coagulation cascade to enable clot formation in Factor VIII and IX-deficient plasma, as well as in Factor VIII-deficient mice. In conclusion, this study highlights a novel mechanism in coagulation with therapeutic potential in both targeting systemic coagulation activation as well as in correcting coagulation factor deficiency.
The use of a new calcium mesoporous silica nanoparticle versus calcium and/or fluoride products in reducing the progression of dental erosion

Abstract Objective There is increasingly common the consumption more times a day of foods and acidic drinks in the diet of the population. The present study aimed to evaluate and compare the effects of a calcium mesoporous silica nanoparticle single application of other calcium and/or fluoride products in reducing the progression of dental erosion. Methodology Half of the eroded area was covered of 60 blocks of enamel, after which the block was submitted to the following treatments: (Ca2+-MSN), casein phosphopeptide–amorphous calcium phosphate (CPP-ACP); CPP-ACP/F-(900 ppm F−); titanium tetrafluoride (TiF4 1%) (positive control); sodium fluoride (NaF 1.36%) (positive control); and Milli-Q® water (negative control) before being submitted to a second erosive challenge. A surface analysis was performed via a three-dimensional (3D) noncontact optical profilometry to assess the volumetric roughness (Sa) and tooth structure loss (TSL) and and through scanning electron microscopy (MEV). An analysis of variance (ANOVA) and Tukey’s test were performed. Results Regarding Sa, all experimental groups exhibited less roughness than the control (p<0.05). The TSL analysis revealed that the Ca2+-MSN and NaF groups were similar (p>0.05) and more effective in minimizing tooth loss compared with the other groups (p<0.05). Conclusions The Ca2+-MSN and NaF treatments were superior compared with the others and the negative control.
Parents’ experiences with pediatric chronic pain

ABSTRACT Introduction Pediatric chronic pain affects 15%–39% of children. Chronic pain can have significant negative effects on a child’s physical functioning, psychological and cognitive functioning, quality of life, and social functioning. Parents of children with chronic pain have reported being affected by their child’s condition. There have been few studies exploring the experiences of parents of children with chronic pain through a qualitative descriptive lens. Methods Thirteen parents from a pediatric chronic pain clinic participated in semistructured interviews. Concurrent data collection and analysis occurred to allow for follow-up of ideas that emerged during analysis. Three phases of analysis occurred: coding, categorizing, and developing themes. Results Three themes were developed: (1) Parents’ emotional journey; (2) chronic pain affects the entire family; and (3) social support is critical. Parents described emotions caused by the arduous process of obtaining a chronic pain diagnosis, followed by difficulties finding strategies to help their child manage the pain. Family life was affected because special accommodations often had to be made. Families were affected financially, incurring costs due to time off of work or additional therapies. Finally, parents stressed the importance of a strong social support network to provide assistance and flexibility for the changing needs of their child. Discussion This research identified a better understanding of the impact of pediatric chronic pain on parents. These findings can be used to provide and promote more effective treatments and education to improve the psychological, physical, and social well-being of children with pediatric chronic pain and their families.
Detecting UAVs Using Acoustic Camera

— Over the past decade, a huge increase in production and operation of Unmanned Aerial Vehicles (UAVs) has been present on a global scale. To maintain the required level of safety and to accommodate the expanding traffic, the governments worldwide have implemented regulations to operations of UAVs. Nonetheless, in recent years there have been numerous safety and security incidents with UAVs, which prompted an increase in research of surveillance and interdiction methods tailored for UAVs. Detection of UAVs using acoustic camera, which is the primary topic of this paper, is possible due to UAV’s propeller noise which is predominant noise source, at least in multicopter UAVs. We performed a detectability test of a commonly used custom made UAV type – multirotor with 6 motors. We concluded that small multirotor UAVs can be detected with acoustic camera, a human interpreter is necessary for detection due to the background noise, maximum detection range can be greater than with visual detection, and UAV detectability depends on UAV noise spectrum, its ratio to background noise, the dynamic range of acoustic camera, and its frequency resolution.
Exposure of Agrobacterium tumefaciens to agroinfiltration medium demonstrates cellular remodeling and may promote enhanced adaptability for molecular pharming.

Agroinfiltration is used to treat plants with modified strains of Agrobacterium tumefaciens for the purpose of transient in planta expression of genes transferred from the bacterium. These genes encode valuable recombinant proteins for therapeutic or industrial applications. Treatment of large quantities of plants for industrial-scale protein production exposes bacteria (harboring genes of interest) to agroinfiltration medium that is devoid of nutrients and carbon sources for prolonged periods of time (possibly upwards of 24 h). Such conditions may negatively influence bacterial viability, infectivity of plant cells, and target protein production. Here, we explored the role of timing in bacterial culture preparation for agroinfiltration using mass spectrometry-based proteomics to define changes in cellular processes. We observed distinct profiles associated with bacterial treatment conditions and exposure timing, including significant changes in proteins involved in pathogenesis, motility, and nutrient acquisition systems as the bacteria adapt to the new environment. These data suggest a progression towards increased cellular remodelling over time. In addition, we described changes in growth- and environment-specific processes over time, underscoring the interconnectivity of pathogenesis and chemotaxis-associated proteins with transport and metabolism. Overall, our results have important implications for the production of transiently-expressed target protein products as prolonged exposure to agroinfiltration medium suggests remodeling of the bacterial proteins towards enhanced infection of plant cells.