Miracle-dz/UniFAR-FTUs huggingface dataset:
In-Vitro, Ex-Vivo and In-Vivo Evaluation of Transdermal Delivery of Felodipine

Felodipine, an effective calcium channel blocker, widely used for the treatment of chronic stable angina and hypertension seems to be potential therapeutic transdermal system candidate, mainly due to its low oral bioavailability, short half life and high first-pass metabolism. Hence an attempt was made to develop transdermal therapeutic systems for felodipine using the polymer blend of eudragit RL100 (ERL) and hydroxypropyl methylcellulose (HPMC) by casting method and to study the effect of polymer composition, plasticizer and permeation enhancer on the physico-mechanical and in vitro drug release characteristics of the film. Polyethylene glycol 400 (PEG 400) and span 60 were used as plasticizer and permeation enhancer respectively. Incorporation of HPMC and PEG 400 improved the flexibility, folding endurance and handling properties and in vitro drug release of the films. The patches were also evaluated for ex vivo skin permeation using human cadaver skin. The presence of span 60 produced significant increase in the flux and permeability. The formulation with ERLHPMC ratio 2:3,4% w/w span 60 as permeation enhancer and 7.5% w/w PEG 400 as plasticizer showed the best results which exhibited the cumulative percentage of drug release of 84.96% and the cumulative amount of drug permeation across skin of 4861.4ng/cm 2 in 24 hrs. In vivo studies of this transdermal system in rabbits demonstrated a four fold enhancement of bioavailability of felodipine relative to oral administration. It may be concluded that the fabricated transdermal delivery system have the potential to provide controlled and extended drug release, better bioavailability and thus, they may improve the patient compliance.
Development and Preliminary Evaluation of a Lower Body Exosuit to Support Ankle Dorsiflexion

For patients suffering from drop foot due to weakness of ankle dorsiflexion muscles, an ankle foot orthosis provides increased foot clearance during the swing phase of gait, but often restricts other gait functions, such as plantarflexion. Due to steady progress in the development of lighter and smaller actuator technologies, active wearable devices such as exosuits become relevant for rehabilitation, since they can offer an extended functionality including a more comfortable wear than passive plastic orthosis. The aim of the paper is to present a lightweight exosuit supporting dorsiflexion during gait with autonomous recognition of gait phases and conditions. One main requirement during the iterative development of the exosuit is a non-restrictive function, thus no differences between the assisted and non-assisted gait of a healthy subject should occur. We therefore conducted a pilot biomechanics study using statistical parametric mapping to analyze kinematics of the ankle joint and muscle activity of m. tibialis anterior of nine subjects without any gait anomalies walking with and without the exosuit. The results show no significant difference between with and without support. In contrast to passive orthosis, the developed system could be an enhanced solution to assist patients suffering from drop foot, which should be analyzed in the next step for evaluating the development.
Reduction of Impulsive Noise from Speech and Audio Signals by using Sd-Rom Algorithm

Removal of noise is the heart for speech and audio signal processing. Impulse noise is one of the most important noise which corrupts different parts in speech and audio signals. To remove this type of noise from speech and audio signals the technique proposed in this work is signal dependent rank order mean (SD-ROM) method in recursive version. This technique is used to replace the impulse noise samples based on the neighbouring samples. It detects the impulse noise samples based on the rank ordered differences with threshold values. This technique doesn’t change the features and tonal quality of signal. Rank ordered differences is used for detecting the impulse noise samples in speech and audio signals. Once the sample is detected as corrupted sample, that sample is replaced with rank ordered mean value and this rank ordered mean value depends on the sliding window size and neighbouring samples. This technique shows good results in terms of signal to noise ratio (SNR) and peak signal to noise ratio (PSNR) when compared with other techniques. It mainly used for removal of impulse noises from speech and audio signals.
Inclusive Transnational Education Partnerships: A Case Study of a Master of Arts in TESOL Program

Recent nationalist and isolationist policies coupled with travel restrictions have prompted a shift in perspectives on the internationalization of higher education. Furthermore, criticisms surrounding issues such as the widespread adoption of English as a medium of instruction in higher education and quality assurance of transnational programs have emerged, with increasing calls for more inclusive models and greater emphasis on quality over quantity. This paper presents an evaluative study of a transnational Master of Arts in the Teaching of English to Speakers of Other Languages (MATESOL) program delivered in partnership by an institution in Singapore (SI) and a university in New Zealand (NZU) and designed for English language teachers from the Association of Southeast Asian Nations (ASEAN) region. Drawing on an impact evaluation, the paper identifies key design features in the program that contributed to its effectiveness as an inclusive model of English medium instruction (EMI) and internationalization in transnational higher education (TNHE).
Twitter'da Duygu Analizi Yöntemi Kullanılarak Bitcoin Değer Tahminlemesi

Butun sektorler dahilinde finans sektorunde de musterilere ait fikir ve dusuncelerinin belirlenmesi, firma ve kurumlarin ileriki donemler icin sunacagi hizmetleri etkilemektedir. Kripto para birimlerinin (Bitcoin, Ethereum, Ripple vb.) ekonomik ve sosyal etkileri hizla artmaya devam ettikce, ilgili haber makalelerinin ve sosyal medya yayinlarinin, ozellikle de tweetlerin yayginligi da artmaktadir. Bu calismada, Twitter kullanicilarinin finans sektoru konularindan biri olan Bitcoin ile ilgili yorumlari derlenerek bir duygu analizi calismasi yapilmistir. Kullanici yorumlari, Twitter’in sunmus oldugu API hizmeti vasitasiyla Python Programlama Dili kullanilarak alinmis; yorumlar olumlu, notr ve olumsuz etiketler ile ayristirilmis, etiket bulutunda toplanmistir. Naive Bayes ve Lojistik Regresyon algoritmalari kullanilarak olusturulan modellerde basari oranlari karsilastirilmistir. Naive Bayes uygulamasinin tweetlerin duygularini tahmin etmedeki basari orani %72,19 olurken, Lojistik Regresyon uygulamasinda bu oran %75,53 olmustur. Calismanin ikinci asamasinda ise, duygu analizinden sonra “Bitcoin” anahtar kelimesi iceren gunluk pozitif tweet orani ile Bitcoin gunluk acilis degeri beraber kullanilarak Bitcoin kapanis degeri tahminlemesi yapilmistir. Finans verileri Yahoo Finance web sitesi uzerinden alinmis; Dogrusal Regresyon ve Rastgele Orman Regresyon yontemleri ile modeller olusturulmustur. Dogrusal Regresyon icin r² degeri %88,97 cikarken, Rastgele Orman Regresyonu icin ise %94,16 olmustur. Anahtar Kelimeler: Duygu analizi, Twitter, Bitcoin, Makine ogrenmesi, Veri madenciligi, Finans
Dual-switchable surfaces between hydrophobic and superhydrophobic fabricated by the combination of click chemistry and RAFT

A dual-switchable surface between hydrophobic and superhydrophobic has been fabricated successfully by com- bining reversible addition-fragmentation chain transfer polymerization (RAFT) polymeric technology and thiol-NCO click chemistry. Well-defined block copolymer, poly(7-(6-(acryloyloxy) hexyloxy) coumarin)-b-poly(N-Isopropylacryl amide), was synthesized by RAFT, and then the block copolymer was grafted onto the surface of SiO2 modified by toluene disocy- nate (TDI) via thiol-NCO click chemistry. The results of nuclear magnetic resonance (NMR) and Fourier Transform Infrared (FTIR) spectroscopies confirmed that the block copolymer (Number average molecular weight (Mn) = 9400, poly- dispersity index (PDI) = 1.22) has been synthesized successfully. The static contact angle (CA) of the surface prepared by SiO2/P (7-6-AC)-b-PNIPAAm switches from 98±2 to 137±2° by adjusting the temperature. Furthermore, the contact angle can also oscillate between 137±2 and 157±2° on the irradiation of UV light at 365 and 254 nm, respectively. The dual-switch- able surfaces exhibit high stability between hydrophilicity and superhydrophobicity. Therefore, the method provides a new method to fabricate the dual-stimuli-responsive surface with tunable wettability, reversible switching, and also be easily extended to other dual-responsive surfaces. This ability to control the wettability by the adjustment of the temperature and UV light has applications in a broad range of fields.
How is Trait Self-Compassion Used During Appearance-Related Distress by Late Adolescents and Emerging Adults With Positive or Negative Body Image? A Qualitative Study

Having a positive body image contributes to adolescents’ and emerging adults’ psychological well-being. One approach to protecting one’s body image from appearance threats involves adopting a self-compassionate perspective. This study explored how six different facets of trait self-compassion are used by late adolescents and emerging adults to cope with appearance-related distress. Following Institutional Review Board approval, in-depth interviews were conducted with 16 female and 14 male undergraduates (Mage = 18.77 years, SD = 1.77 years) who reported either positive or negative body image and high or low self-compassion. Adopting a descriptive/confirmative approach, data were analyzed via an a priori coding system based on the six facets of self-compassion. Only one self-compassion facet, self-kindness, was reportedly used to counteract body-related distress, and only by those with a positive body image. Most participants with negative body image engaged in self-judgment, with some expressing a fear of self-kindness. Despite being acknowledged by all, the facet of common humanity was not used for appearance-related affect regulation. Participants showed limited practice of the mindfulness facet. Together, the findings show that scope remains for achieving reductions in body image distress, and corresponding gains in resilience, through self-compassion interventions.
VALUES SUPPORTING THE SUSTAINABILITY OF INCLUSIVE EDUCATION IN DIFFERENT PRACTICES

This article analyses how fundamental values underpin educational practices that have emerged in the development of society and create the preconditions for the sustainability of inclusive education. Through the analysis of the scholarly literature, the expression of inclusive values in the application of approaches to integrated, individualised inclusive education and Universal Design for Learning is analysed. It has been established that the effectiveness of inclusive education is substantiated in practices which are based on real existing inclusive values: equity, equality, communality and respect for diversity. Based on the results of the study, it is concluded that the sustainability of inclusive education coincides with the real existence of inclusive values in practice, equally applying to all students.
The Impact of the Politicization of Health on Online Misinformation and Quality Information on Vaccines

In July 2017, a law aimed at reversing the decline in vaccination cover (Law 119/2017) made child vaccination mandatory in Italy. The law sparked a heated debate which was a breeding ground for disinformation and misinformation but also set the stage for some initiatives that have tried to combat the problem. This paper analyzes the Twitter vaccine-related information environment by focusing on the information sources shared by about 500,000 tweets published within three years – 18 months before and after the promulgation of the Law 119/2017 on mandatory vaccinations – highlighting clusters of sources shared by the users and changes in problematic and quality information throughout that period. Results show that the politicization of the topic was associated with the growing spread of problematic information. They expose the vaccine-related information environment as characterized by an homophilic and polarized structure grouping together and opposing, on the one hand, anti-vaccination, blacklisted sources, alternative therapy and conspiracy websites, and on the other, scientific and health sources, revealing that despite the new initiatives aimed at increasing quality information and fighting problematic information online, there was a lack of scientific information both during and after the debate on the vaccinations law, while problematic information appears to have increased in volume over the years.
Prevalence and risk of chronic kidney disease in oral lichen planus: a large cross-sectional study from eastern China

Background Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease which is frequently associated with comorbidities such as diabetes and cardiovascular diseases. However, little is known about the association of OLP with impaired kidney function. To elucidate the possible association of chronic kidney disease (CKD) with OLP and its severity, this study investigated the prevalence of CKD as well as its risk factors in patients with OLP. Methods A large prospective cross-sectional study of 1,021 patients with OLP was carried out using questionnaires and laboratory tests available from an oral medicine clinic at a university in eastern China. According to the Kidney Disease: Improving Global Outcomes (KDIGO) diagnostic guideline, CKD was classified based on the estimated glomerular filtration rate (eGFR, <60 mL/min/1.73 m2) or urinary albumin to creatinine ratio (UACR, >30 mg/g). Results The prevalence of CKD in the patients with OLP in this study was 14.3% (95% CI, 12.3–16.6%), which was higher than that in the general Chinese population (10.8%; 95% CI, 10.2–11.3%). The mean values of serum creatinine, eGFR, UACR, and urine N-acetyl-β-D-glucosidase in patients with CKD were significantly higher than those in patients without CKD (all P<0.01). Pearson’s correlation analysis revealed that CKD stage and UACR were positively correlated with the severity of OLP (both P<0.001). Importantly, multivariate regression analysis revealed that age ≥58 years old, female sex, and hypertension were independent risk factors for incident CKD and abnormal UACR (>30 mg/g) in patients with OLP (all P<0.01). Conclusions This study has reported for the first time that CKD is a comorbidity in patients with OLP. The occurrence and staging of incident CKD are associated with OLP and its severity.
Preparation and characterization of Y doped Ti/Sb_2O_5-SnO_2 electro-catalytic electrodes

Yttrium was selected as a promoter for the Ti/Sb2O5-SnO2 electrode to enhance its electro-catalytic characteristics and Y doped Ti/Sb2O5-SnO2 electrodes were prepared by the immersion method.Degeneracy of the prepared electrodes was investigated using reactive brilliant red X-3B as a model pollutant.The parameters of preparing the electrode,including temperature and Y doping content,were studied in detail.The optimal pyrolytic temperature was 550 ℃,and Y doping content was 0.8%. The micrograph of the electrode surface,the element composition of different layers and the structure of the electrode were analyzed by SEM,EDS and XRD.Compared with the Ti/Sb2O5-SnO2 electrode,the average size of SnO2 grains on the electrode surface of the Y doped Ti/Sb2O5-SnO2 electrode was smaller,which implies a potential improvement in catalytic performance.Sb and Y were found to be enriched in the coated layer on the electrode surface when Y was introduced.The surface of the Y doped Ti/Sb2O5-SnO2 electrode was mainly composed of tetragonal rutile structure SnO2 crystal.The potential sweep results indicate that the Y doped Ti/Sb2O5-SnO2 electrode has high oxygen evolution potential which is in favor of electrochemical oxidation for organic pollutants.
A Force Field for Describing the Polyvinylpyrrolidone-Mediated Solution-Phase Synthesis of Shape-Selective Ag Nanoparticles

Polyvinylpyrrolidone (PVP), ethylene glycol (EG), and polyethylene oxide (PEO) are key molecules in the solution-phase synthesis of Ag nanostructures. To resolve various aspects of this synthesis, we develop a classical force field to describe the interactions of these molecules with Ag surfaces. We parametrize the force field through force and energy matching to results from first-principles density-functional theory (DFT). Our force field reproduces the DFT binding energies and configurations of these molecules on Ag(100) and Ag(111). Our force field also yields a binding energy for EG on Ag(110) that is in agreement with experiment. Molecular-dynamics simulations based on this force field indicate that the preferential binding affinity of the chains for Ag(100) increases significantly beyond the segment binding energy for PVP decamers, but not for PEO. This agrees with experimental observations that PVP is a more successful structure-directing agent than is PEO.
Three-Dimensional Reconstruction-Based Vibration Measurement of Bridge Model Using UAVs

This paper presents a measurement method of bridge vibration based on three-dimensional (3D) reconstruction. A video of bridge model vibration is recorded by an unmanned aerial vehicle (UAV), and the displacement of target points on the bridge model is tracked by the digital image correlation (DIC) method. Due to the UAV motion, the DIC-tracked displacement of the bridge model includes the absolute displacement caused by the excitation and the false displacement induced by the UAV motion. Therefore, the UAV motion must be corrected to measure the real displacement. Using four corner points on a fixed object plane as the reference points, the projection matrix for each frame of images can be estimated by the UAV camera calibration, and then the 3D world coordinates of the target points on the bridge model can be recovered. After that, the real displacement of the target points can be obtained. To verify the correctness of the results, the operational modal analysis (OMA) method is used to extract the natural frequencies of the bridge model. The results show that the first natural frequency obtained from the proposed method is consistent with the one obtained from the homography-based method. By further comparing with the homography-based correction method, it is found that the 3D reconstruction method can effectively overcome the limitation of the homography-based method that the fixed reference points and the target points must be coplanar.
Influences of Additives on HMX Crystal Morphology

The influences of additives(acetamide,acrylamide and ethylamine) on HMX crystal morphology were studied by theoretical computation and experiment methods.The results show that the sequence of additives influences on HMX crystal morphology was: acetamide acrylamide ethylamine.Acetamide had negative influence on HMX crystal morphology and made HMX crystal morphology change in non-spherical direction,and acrylamide had active influence on HMX crystal morphology.Due to the attachment energy of ethylamine to HMX crystal faces was low,a clear variation of HMX crystal morphology has not been founded.The results of experiments have a good agreement with theoretical computation results.The additives have no influence on crystal purity.The acrylamide made the sensitivity of HMX crystal change better and the stability of HMX crystal change little.
Ancient oriental pattern and related zeolite type networks

Several zeolite structure types show the typical projection of ferrierite down the c-direction, a pattern that is also present in some examples of early-oriental art. Unbranched zweier, dreier and vierer single chains as well as selected complex silicate chains are used as building units in order to generate structure models of this kind. For the single chains the construction principle is based on an appropriate interpretation of the edges of the projection net as projected chains. A subset of higher symmetric models is analysed in more detail with the distance least-squares method. Introduction A number of tilings in ancient oriental art can be associated with projections of several zeolite structures. A typical example is the ferrierite projection down c, shown in Figure 1, which can be found in Indian art of the 17th century. There are also tilings of this kind in an 18th century decoration of the Masjid-i-Jami at Isfahan, Iran (El-Said and Parman, 1976), where beautiful rosettes decorate the 10-membered rings (Fig. 2). The zeolite structure types shown in Table 1 can be characterized by their common ferrierite projection. The aim of this paper is to give an idea of the diversity of possible structures with this projection. The construction principle of the model structures is based on the interpretation of the edges of the projection net as projected single chains and their Τ—Ο—Τ linkages to other chains, see Figure 3. The combination of chains with nets has been discussed extensively by Smith (1979, 1983). In order to limit the number of the various models we restrict ourselves to structures with lattice constants a and b as depicted in Figure 3 and mainly 238 R. Gramlich-Meier Fig. 1. Schematic picture of an Indian pattern from the Mausoleum of Γ timäd al-Dawla, Agra (El-Said and Parman, 1976) compared to the ferrierite projection down c. Fig. 2. Drawing of the ferrierite-like tiles from the Masjid-i-Jami, Isfahan, Iran (El-Said and Parman, 1976). to the simplest chain types in the direction perpendicular to the projection as shown in Figure 4. A similar selection has been used by Smith (1979). As mentioned by Liebau (1985) the description of silicate frameworks with chains as building units is only one of several different kinds of classification. However, in this case it is the simplest method of structure generation. Structure models with single chains If the structures are considered to be built up from identical chains perpendicular to the ferrierite projection, linked by oxygen atoms, each node of the projection can be associated with only one chain (cf. Fig. 3). ConsiderZeolite type networks 239 Table 1. Known zeolite structures with "ferrierite projection".
Application of Visible/Near Infrared Spectrometers to Quickly Detect the Nitrogen, Phosphorus, and Potassium Content of Chemical Fertilizers

The rapid determination of nitrogen, phosphorus, potassium and other major nutrient elements is an important technical guarantee in the quality control of chemical fertilizers. In this study, a small visible spectrometer and a small near-infrared spectrometer were used to collect spectrum information of 33 different common chemical fertilizers including compound fertilizers, blended fertilizers and controlled-release fertilizers. The 550~950 nm and 1050~1640 nm spectra with stable signals were intercepted as the analysis spectrum, and the competitive adaptive reweighted sampling algorithm (CARS) was used to select 161, 229, and 161 spectral characteristic wavelengths for the three nutrient contents of N, P2O5, and K2O respectively. The partial least squares (PLS) and extreme learning machine (ELM) models of N, P2O5, and K2O were established based on the 550~950 nm waveband, 1050~1640 nm waveband, full spectrum, and characteristic wavelength, respectively. The coefficient of determination (R2), root mean square error (RMSE), and residual predictive deviation (RPD) were used to evaluate the effect of the model. With the optimal prediction models, the values of Rp2 for N, P2O5, and K2O were 0.989, 0.963, 0.981, and for RPD were 9.71, 5.09, 7.29, respectively. The research results show that Vis/NIR spectroscopy can predict the content of nitrogen, phosphorus, and potassium nutrients in fertilizers, and the near-infrared band from 1050 nm to 1640 nm has a better prediction effect. The characteristic wavelength selection reduces the spectral variables by 9/10, and the performance of the model based on the characteristic wavelength is close to that of the full-spectrum model.