Miracle-dz/UniFAR-FTUs huggingface dataset:
Excessive hoarding in Parkinson's disease

Hoarding is seen in several psychiatric conditions, but has not been specifically assessed in Parkinson's disease (PD). This study investigates hoarding tendency amongst patients with PD, and its association with impulsive‐compulsive spectrum behaviors (ICBs). We compare clinical features, measures of hoarding, impulse buying, self‐control, obsessive‐compulsive symptoms, depression, and anxiety in 39 patients with PD with ICBs (PD + ICB), 61 patients with PD without ICBs (PD − ICB), and 50 healthy controls. A much higher proportion of PD + ICB (27.8%) than PD − ICB (3.5%) were hoarders (P = 0.001). 6% of healthy controls were hoarders. Compulsive shoppers scored higher than other varieties of ICB on excessive acquisition measures. Hoarding correlated positively with impulsive buying, obsessive‐compulsive symptoms, PD duration, and negatively with self‐control measures. Using multivariate regression analyzes, the presence of ICBs and measures of impulsive buying were the only variables independently associated with hoarding in PD. The association of hoarding with other ICBs and low trait impulse control suggests that excessive hoarding is related to the spectrum of impulsive behaviors in PD. © 2010 Movement Disorder Society
Quantification of sleepiness: a new approach.

The Stanford Sleepiness Scale (SSS) is a self-rating scale which is used to quantify progressive steps in sleepiness. The present study investigated whether the SSS cross-validates with performance on mental tasks and whether the SSS demonstrates changes in sleepiness with sleep loss. Five college student Ss were given a brief test of memory and the Wilkinson Addition Test in 2 test sessions and The Wilkinson Vigilance Test in 2 other sessions spaced throughout a 16-hr day for 6 days. Ss made SSS ratings every 15 min during their waking activities. On night 4, Ss underwent all night sleep deprivation. On all other nights, Ss were allowed only 8 hrs in bed. Mean SSS ratings correlated r= . 68 with performance on the Wilkinson Tests. Discrete SSS ratings correlated r= . 47 with performance on the memory test. Moreover, mean baseline SSS ratings were found to be significantly lower than corresponding ratings of the deprivation period.
Simultaneous energy supply and demand management in microgrids : A comparative study of MILP formulations

This paper analyses the operational decision making procedures required to address the simultaneous management of energy supplies and requests in a microgrid scenario, in order to best accommodate arbitrary energy availability profiles resulting from an intensive use of renewable energy sources, and to extensively exploit the eventual flexibility of the energy requirements to be fulfilled. The optimization of the resulting short term scheduling problem in deterministic scenarios is addressed through a Mixed-Integer Linear Programming (MILP) mathematical model, which includes a new hybrid time formulation developed to take profit of the advantages of the procedures based on discrete time representations, while maintaining the ability to identify solutions requiring a continuous time representation, which might be qualitatively different to the ones constrained to consider a fixed time grid for decision-making. The performance of this new time representation has been studied, taking into account the granularity of the model and analyzing the associated trade-offs in front of other alternatives. The promising results obtained with this new formulation encourage further research regarding the development of decision-making tools for the enhanced operation of microgrids.
A Flow Rate Independent Cell Concentration Measurement Chip Using Electrical Cell Counters Across a Fixed Control Volume

We present a novel method of measuring cell concentration using two electrical cell counters across a fixed control volume. Our device counts cells at the inlet and outlet of a fixed control volume and then measures the cell concentration by calculating the number of cells in the fixed control volume. Previous methods of measuring cell concentration (such as a Coulter counter and a flow cytometer) have attempted to count cells in a given fluid volume or at a known flow rate. Thus, in spite of the miniature nature of previous devices, the accuracy of their results depends on the performance of external mechanisms such as delicate pumps and flow sensors. Our prototype, however, does not depend on accurate fluid measurement or precise control of the flow rate because it measures the number of cells in a fixed control volume. In the experimental study, we measured cell concentrations ranging from 5.8 times 105 to 11.5 times 105 cells/mL without measuring or controlling the flow rate. For measuring the cell concentration, our prototype shows a maximum cell concentration measurement error of 10.3%, which is within the error range of a hemacytometer.
Psychiatric disorder and cognitive impairment in systemic lupus erythematosus.

OBJECTIVES To determine the point prevalence of psychiatric disorder in patients with systemic lupus erythematosus (SLE). To investigate associations between psychiatric disorder and social stress, cognitive impairment, systemic disease activity, and corticosteroid therapy. METHODS A cross-sectional study of 73 consecutive patients with SLE assessed using standardized psychiatric and clinical research methods. RESULTS Current psychiatric disorder was present in 15 patients (20.5%) and was significantly associated with social stress, lack of social support, and impairment on 2 tests of cognitive function (Verbal Fluency Test and Benton Visual Retention Test, Part A, number of errors). There was no association with systemic disease activity or corticosteroid therapy. Cognitive impairment on 2 or more tests was found in 26% and was associated with clinical evidence of central nervous system (CNS) disease, but not systemic disease activity or corticosteroid therapy. CONCLUSIONS The point prevalence of psychiatric disorder in this cohort of patients with SLE was found to be similar to that observed in patients with rheumatoid arthritis. It was independently associated with social stress and 2 indicators of cognitive impairment, but not with systemic disease activity or corticosteroid therapy. Marked cognitive impairment was present in a significant percentage of patients even when there was no overt evidence of CNS involvement.
Notice of RetractionA method to device flow hash algorithm based traffic character

Flow sampling algorithms and data streaming algorithms have widely adopted the hashing algorithms to detect flow information at the high-speed links for the applications of the flow distribution, the number of flow, the heavy-tailed flow, and so on. Hashing algorithms involve transforming a key inside a hash value. But there arenpsilat hash algorithms which are designed for flow measurement. In this paper, we propose a method to design flow hash algorithm based on traffic character. A bit probability distance metric is given to design a flow hash algorithm, and a flow hash algorithm is given using a CERNET trace, and the flow hash algorithm is compared with Bob and CRC hash algorithms by an uniformity test, the number of active flows tests, and a speed test. The experimental result shows that the flow hash algorithm is superior to others hash algorithms.
Cytokines and immunoglobulin g response in donkeys with spontaneous Setaria equine infection

Setaria equina (S. equina) is a filarial worm that exists in peritoneal cavity of equines. This study aimed to evaluate cytokine mediators tumour necrosis factor alpha (TNF-α), interleukin-4 (IL-4) and immunoglobulin G (IgG) responses in spontaneously S. equina infected and non-infected donkeys with emphasis on choosing the best antigen that could be used in diagnosis of such filarial infection. A total of 87 donkeys were examined. Two S. equina antigens: crude somatic S. equina antigen (CSS) and excretory secretory S. equina antigen (ESS) were prepared. They were evaluated in diagnosis of the infection using indirect ELISA and electrophoretically characterised through sodium dodecyl sulphate poly acrylamide gel electrophoresis (SDS-PAGE) and western blotting technique. The results indicated that both TNF-α and IL-4 in the serum of infected donkeys were significantly higher compared with the non-infected group at P<0.05 and P<0.01, respectively. However, the IL-4 level of infected donkeys was significantly higher than that of TNF-a (P<0.01). Apparent prevalence, specificity and positive predictive values (96.55%, 100%, and 100% each) of CSS showed higher diagnostic accuracy than that of ESS. In addition, electrophoretic protein profile and IgG reactivity of CSS antigen via western blot presented a prominent reactive protein band at 28 kDa. It was concluded that the CSS antigen was the best antigen that could be used in serodiagnosis of S. equina infection. The cytokine responses were explored in order to differentiate infected from non-infected donkeys.
Development of a Client-Server System for 3D Scene Change Detection

In this paper, we present a client-server system for 3D scene change detection. A 3D scene point cloud which stored on the server is reconstructed by (structure-from-motion) SfM technique in advance. On the other hand, the client system in tablets captures query images and sent them to the server to estimate the change area. In order to find region of change, an existing change detection method has been applied into our system. Then the server sends detection result image back to mobile device and visualize it. The result of system test shows that the system could detect change cor- rectly.
THE ROLE OF IT DEPARTMENTS IN THE ENHANCEMENT OF BANKS’ PROJECT MANAGEMENT

Contemporary business conditions put a lot of pressure on organizations in basically all industries to successfully maintain or increase their competitiveness. That is also true of the very dynamic banking and financial sectors. Managing change is of special importance for the banks’ competitiveness and thus non-standard activities or processes, namely projects, need to be performed on a permanent basis. The progressively growing complexity of business environments demands a corresponding increase in the number of projects to be carried out while bearing in mind the fact that projects in the banking sector need to follow some specific rules, at least it terms of formal regulations and confidentiality norms that are to be observed in this sector. A bank’s IT department is generally the only sector in the bank that is fully project-oriented. In this paper its role is presented as the axis of the bank’s multiple projects environment and thus the axis of the bank’s development. Also, the role of the bank’s IT department in enhancing the bank's project management maturity will be clarified. Sažetak Zbog suvremenih uvjeta poslovanja organizacije u gotovo svim gospodarskim granama pod velikim su pritiskom da zadrže ili povećaju svoju konkurentnost. Isto vrijedi i za vrlo dinamičan bankarski i financijski sektor. Upravljanje promjenama posebno je važno za konkurentnost banaka pa stoga aktivnosti ili procese koji nisu standardni, drugim riječima projekte, valja stalno provoditi. Sve veća složenost poslovnih okruženja zahtijeva odgovarajuće povećanje broja projekata koje treba provesti imajući na umu činjenicu da projekti u bankarskom sektoru moraju slijediti neka specifična pravila, barem što se tiče formalnih pravila i normi za zaštitu povjerljivosti kojih se treba pridržavati. IT odjel najčešće je jedini sektor banke koji je u potpunosti projektno usmjeren. U ovom radu njegova je uloga predstavljena kao osovina multiprojektnog okruženja banke pa tako i razvoja banke. Nadalje, objasnit ćemo i ulogu IT odjela banke u unapređenju projektnoga menadžmenta u bankama.
Novel Streptomycin Resistance Gene from Mycobacterium fortuitum

ABSTRACT We have isolated the aph(3")-Ic gene, encoding an aminoglycoside 3"-O-phosphotransferase [APH(3")-Ic], from a genomic library of an environmental Mycobacterium fortuitum strain, selecting for streptomycin resistance. APH(3")-Ic phosphorylates and inactivates streptomycin. Similar genes have been described in Streptomyces griseus and plasmid RSF1010. It is also present in some M. fortuitum clinical isolates.
Comparison of two low‐density lipoprotein apheresis systems in patients with homozygous familial hypercholesterolemia

Low‐density lipoprotein (LDL) apheresis (LA) is a reliable method to decrease LDL‐C concentrations and remains the gold standard therapy in homozygous familial hypercholesterolemia (HoFH). The objective of this study was to compare the efficacy of two LA systems [heparin‐induced extracorporeal LDL precipitation (HELP) vs. dextran sulfate adsorption (DS) on the reduction of lipids, inflammatory markers, and adhesion molecules in a sample of genetically defined HoFH subjects (n = 9)]. Fasting blood samples were collected before and after LA. All subjects served as their own control and were first treated with the HELP system then with DS in this single sequence study. Compared with HELP, DS led to significantly greater reductions in total cholesterol (−63.3% vs. −59.9%; P = 0.05), LDL‐C (−70.5% vs. −63.0%; P = 0.02), CRP (−75.3% vs. −48.8%; P < 0.0001), and TNF‐α (−23.7% vs. +14.7%; P = 0.003). Reductions in the plasma levels of PCSK9 (−45.3% vs. −63.4%; P = 0.31), lipoprotein (a) (−70.6% vs. −65.0%; P = 0.30), E‐selectin (−16.6% vs. −18.3%; P = 0.65), ICAM‐1 (−4.0 vs. 5.6%; P = 0.56), and VCAM‐1 (8.3% vs. −1.8%; P = 0.08) were not different between the two systems. For the same volume of filtered plasma (3,000 mL), however, HELP led to greater reductions in plasma apoB (−63.1% vs. −58.3%; P = 0.04), HDL‐C (−20.6% vs. −6.5%; P = 0.003), and PCSK9 (−63.4% vs. −28.5%; P = 0.02) levels. These results suggest that both LA systems are effective in reducing plasma lipids and inflammatory markers in HoFH. Compared with HELP, greater reductions in lipid levels and inflammatory markers were achieved with DS, most likely because this method allows for a larger plasma volume to be filtered. J. Clin. Apheresis 31:359–367, 2016. © 2015 Wiley Periodicals, Inc.
Ultradian corticosterone secretion is maintained in the absence of circadian cues

Plasma levels of corticosterone exhibit both circadian and ultradian rhythms. The circadian component of these rhythms is regulated by the suprachiasmatic nucleus (SCN). Our studies investigate the importance of the SCN in regulating ultradian rhythmicity. Two approaches were used to dissociate the hypothalamic‐pituitary‐adrenal (HPA) axis from normal circadian input in rats: (i) exposure to a constant light (LL) environment and (ii) electrolytic lesioning of the SCN. Blood was sampled using an automated sampling system. As expected, both treatments resulted in a loss of the circadian pattern of corticosterone secretion. Ultradian pulsatile secretion of corticosterone however, was maintained across the 24 h in all animals. Furthermore, the loss of SCN input revealed an underlying relationship between locomotor and HPA activity. In control (LD) rats there was no clear correlation between ultradian locomotor activity and hormone secretion, whereas, in LL rats, episodes of ultradian activity were consistently followed by periods of increased pulsatile hormone secretion. These data clearly demonstrate that the ultradian rhythm of corticosterone secretion is generated through a mechanism independent of the SCN input, supporting recent evidence for a sub‐hypothalamic pulse generator.
Leukopheresis therapy for severe infantile pertussis with myocardial and pulmonary failure

Objective: To describe an infant with severe pertussis successfully treated with leukopheresis. Design: Case report. Setting: Pediatric intensive care unit of a children’s hospital. Patient: Five-wk-old female with pertussis complicated by cardiorespiratory failure. Interventions: Single leukopheresis treatment. Measurements and Main Results: Normalization of the white blood cell count and marked cardiorespiratory improvement after treatment; patient survived. Conclusion: Given the temporal association between treatment and improvement, we hypothesize that the markedly elevated white blood cell count has a major role in the cardiopulmonary compromise.
Single-layer transmissive phase gradient metasurface with high-efficiency anomalous refraction

A novel transmissive phase gradient metasurface (GPGM) is proposed to obtain high efficiency anomalous refraction. The super-cell of GPGM is constructed from six rotated unit cells having high transmission efficiency. The GPGM can provide the desired adverse phase gradients for left- and right-handed circularly polarized (LCP and RCP, respectively) waves at 15GHz. Therefore, the transmitted waves under normal incident linearly polarized wave are separated into two counter-directionally propagating circularly polarized waves. The simulated refractive power density spectrum is well consistent with the theoretically designed anomalous refraction direction.
E ’ ratio is more sensitive than E / A ratio for detection of left ventricular diastolic dysfunction in patients with systemic sclerosis

1Division of Rheumatology, 2Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea; 2Department of Internal Medicine, Institute for Immunology and Immunological Disease, BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. Sang-Won Lee, MD, Eui-Young Choi, MD, PhD, Sang Youn Jung, MD, Sang Tae Choi, MD, Soo-Kon Lee, MD, PhD, Yong-Beom Park, MD, PhD Please address correspondence and reprint requests to: Yong-Beom Park, MD, PhD, Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-ku, Seoul, South Korea 120-752. E-mail: yongbpark@yuhs.ac Received on July 3, 2009; accepted in revised form on November 12, 2009. Clin Exp Rheumatol 2010: 28 (Suppl. 58): S12-S17. © Copyright CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 2010.
Determination of required anatomical knowledge for clinical practice in emergency medicine: national curriculum planning using a modified Delphi technique

Objectives: To identify the content of the postgraduate anatomy curriculum for trainees in emergency medicine (EM) in the UK. Methods: Modified Delphi technique involving 160 randomly sampled consultants in EM. The outcome measure was percentage agreement, based upon a three round iterated Delphi process, of participants to items derived from a standard anatomy text being core knowledge for postgraduate clinical practice in the specialty. A national curriculum document was derived as a result of the data obtained. Results: Response rates ranged from 61% to 70% after three Delphi rounds. From an initial overall questionnaire content of 808 discrete items, 64% was retained as core required knowledge following iteration. This formed the basis of a national consensus anatomy curriculum both to inform question development in postgraduate EM examinations and to benchmark anatomical knowledge requirements for safe clinical practice. Conclusions: Application of a national consensus methodology allows for determination of curricular content in anatomy. The principles can be applied to all aspects of training and curricular policy at national collegiate level to guide the development of robust documentation.
Pharmacogenetic tests to predict the efficacy of aspirin desensitization in patients with aspirin-exacerbated respiratory diseases; HLA-DQB302

This study is aimed at investigating the association of HLA-DRB1, HLA-DQA1, and HLA-DQB1 variability with the response to aspirin desensitization (AD). A total of 16 patients with aspirin-exacerbated respiratory diseases (AERD, 81.3% were female) with median age of 29 ± 4.3 years were included in this study. Following 6 months, Sino-Nasal Outcome Test-22 (SNOT-22), medication, symptom scores, and forced expiratory volume in 1 s (FEV1) (all p < 0.001) improved significantly. However, only seven patients (43.7%) had clinically significant improvement in all of the medication and symptom scores and FEV1, who were considered responders to AD. Responders to AD had significantly higher symptom scores compared with non-responders at baseline (20 ± 1.18 vs 10 ± 1.27; p = 0.003). HLADQB1*0302 was significantly lower in non-responders than in responders to AD (0.12 [0.02–0.76]; p = 0.022). Sensitivity and specificity of HLA-DQB1*0302 to predict response to AD was 71.4% (95% CI: 35.8–91.7) and 81.8% (95% CI: 52.3–94.8). This study introduces HLA-DQB1*0302 as a genetic marker for favorable response to AD.
Platelets and Cancer Metastasis: More Than an Epiphenomenon

In this review we have presented overwhelming evidence that platelets play an important enhancing role in tumor cell-vasculature interactions and cancer metastasis. Tumor cells employ a host of mechanisms to induce platelet aggregation; vice versa, platelets make use of a spectrum of mechanisms to modulate tumor cell-EC and tumor cell-ECM interactions. Various COX and LOX metabolites are closely involved in this bidirectional modulation, thus providing us with a very promising therapeutic avenue by modifying the actions of these metabolites. On the other hand, adhesion molecules are mediators of tumor cell-platelet-EC interactions; therefore interference with these adhesion molecules and various adhesive processes either by soluble peptides, nonpeptidic analogues, or specific antibodies holds great investigational and clinical appeal.
R&D in RF superconductivity to support the international linear collider

The R&D in on superconducting radiofrequency technology for the international linear collider (ILC) spans a broad range of topics, ranging from the search for high gradients through improved processes, new cavity geometries as well as the use of new materials (large- grain and single-crystal niobium metal). Besides these alternatives R&D paths, a large part of the baseline design for the ILC baseline is being going through an industrialisation effort in the framework of the European XFEL project. This paper talk will review the status of the global ILC SRF R&D program and discuss plans for the future.
Noise effects in avalanche photodiodes

The usual formula for the excess noise produced in a simple avalanche photodiode may be introduced in a particularly simple manner by taking advantage of the fact that the ionization coefficients usually encountered in practice are often regarded as constant throughout the device for any specific applied bias voltage. An analytic expression for the hole current as a function of position, along with a novel interpretation of the minimum-noise condition, are also given.