Miracle-dz/UniFAR-FTUs huggingface dataset:
Reliability and accuracy of individual Alberta Stroke Program Early CT Score regions using a medical and a smartphone reading system in a telestroke network

Introduction The aim of this study was to assess individual regions of the Alberta Stroke Program Early CT Score in noncontrast head computed tomography interpretations using a smartphone in a telestroke network, by comparison to a medical monitor. Methods The review board of our institution approved this retrospective study. A factorial design with 188 patients, four radiologists and two reading systems was used. Accuracy and reliability were evaluated. Results Very good interobserver agreements were observed on the total Alberta Stroke Program Early CT Score for both the medical and smartphone reading systems, with intraclass correlation coefficients of 0.91 and 0.84 respectively. Interobserver agreements were moderate to very good for the medical reading system (all intraclass correlation coefficients >0.74), whereas they were fair to very good for the smartphone (intraclass correlation coefficients ranged from 0.31–0.81). All intraobserver agreements were good (intraclass correlation coefficient >0.64), except for internal capsule (0.48) and M2 (0.55) regions. The areas under the receiver-operating curve ranged from 0.69–0.89 for the medical system, while for the smartphone ranged from 0.44–0.86. No statistical differences were observed between medical and smartphone reading systems for each region (all p > 0.05). Discussion If radiologists are better trained in the evaluation of the lesions in the insula, the internal capsule and the M2 regions, the total and the dichotomised Alberta Stroke Program Early CT Score will be more precise. Hence, ruling out contraindications to thrombolysis administration will be improved, allowing assessment of head computed tomography in a telestroke network using a smartphone to be a common practice.
Robust Low-Rank Tensor Minimization via a New Tensor Spectral $k$ -Support Norm

Recently, based on a new tensor algebraic framework for third-order tensors, the tensor singular value decomposition (t-SVD) and its associated tubal rank definition have shed new light on low-rank tensor modeling. Its applications to robust image/video recovery and background modeling show promising performance due to its superior capability in modeling cross-channel/frame information. Under the t-SVD framework, we propose a new tensor norm called tensor spectral k-support norm (TSP-<inline-formula> <tex-math notation="LaTeX">$k$ </tex-math></inline-formula>) by an alternative convex relaxation. As an interpolation between the existing tensor nuclear norm (TNN) and tensor Frobenius norm (TFN), it is able to simultaneously drive minor singular values to zero to induce low-rankness, and to capture more global information for better preserving intrinsic structure. We provide the proximal operator and the polar operator for the TSP-<inline-formula> <tex-math notation="LaTeX">$k$ </tex-math></inline-formula> norm as key optimization blocks, along with two showcase optimization algorithms for medium- and large-size tensors. Experiments on synthetic, image and video datasets in medium and large sizes, all verify the superiority of the TSP-<inline-formula> <tex-math notation="LaTeX">$k$ </tex-math></inline-formula> norm and the effectiveness of both optimization methods in comparison with the existing counterparts.
Exercise intensity-dependent effects of arm and leg-cycling on cognitive performance

Physiological responses to arm and leg-cycling are different, which may influence psychological and biological mechanisms that influence post-exercise cognitive performance. The aim of this study was to determine the effects of maximal and submaximal (absolute and relative intensity matched) arm and leg-cycling on executive function. Thirteen males (age, 24.7 ± 5.0 years) initially undertook two incremental exercise tests to volitional exhaustion for arm-cycling (82 ± 18 W) and leg-cycling (243 ± 52 W) for the determination of maximal power output. Participants subsequently performed three 20-min constant load exercise trials: (1) arm-cycling at 50% of the ergometer-specific maximal power output (41 ± 9 W), (2) leg-cycling at 50% of the ergometer-specific maximal power output (122 ± 26 W), and (3) leg-cycling at the same absolute power output as the submaximal arm-cycling trial (41 ± 9 W). An executive function task was completed before, immediately after and 15-min after each exercise test. Exhaustive leg-cycling increased reaction time (p < 0.05, d = 1.17), while reaction time reduced following exhaustive arm-cycling (p < 0.05, d = -0.62). Improvements in reaction time were found after acute relative intensity arm (p < 0.05, d = -0.76) and leg-cycling (p < 0.05, d = -0.73), but not following leg-cycling at the same absolute intensity as arm-cycling (p > 0.05). Improvements in reaction time following arm-cycling were maintained for at least 15-min post exercise (p = 0.008, d = -0.73). Arm and leg-cycling performed at the same relative intensity elicit comparable improvements in cognitive performance. These findings suggest that individuals restricted to arm exercise possess a similar capacity to elicit an exercise-induced cognitive performance benefit.
Graph Sequence Recurrent Neural Network for Vision-Based Freezing of Gait Detection

Freezing of gait (FoG) is one of the most common symptoms of Parkinson’s disease (PD), a neurodegenerative disorder which impacts millions of people around the world. Accurate assessment of FoG is critical for the management of PD and to evaluate the efficacy of treatments. Currently, the assessment of FoG requires well-trained experts to perform time-consuming annotations via vision-based observations. Thus, automatic FoG detection algorithms are needed. In this study, we formulate vision-based FoG detection, as a fine-grained graph sequence modelling task, by representing the anatomic joints in each temporal segment with a directed graph, since FoG events can be observed through the motion patterns of joints. A novel deep learning method is proposed, namely graph sequence recurrent neural network (GS-RNN), to characterize the FoG patterns by devising graph recurrent cells, which take graph sequences of dynamic structures as inputs. For the cases of which prior edge annotations are not available, a data-driven based adjacency estimation method is further proposed. To the best of our knowledge, this is one of the first studies on vision-based FoG detection using deep neural networks designed for graph sequences of dynamic structures. Experimental results on more than 150 videos collected from 45 patients demonstrated promising performance of the proposed GS-RNN for FoG detection with an AUC value of 0.90.
Exogenous Tebuconazole and Trifloxystrobin Regulates Reactive Oxygen Species Metabolism Toward Mitigating Salt-Induced Damages in Cucumber Seedling

The present study investigated the role of tebuconazole (TEB) and trifloxystrobin (TRI) on cucumber plants (Cucumis sativus L. cv. Tokiwa) under salt stress (60 mM NaCl). The cucumber plants were grown semi-hydroponically in a glasshouse. Plants were exposed to two different doses of fungicides (1.375 µM TEB + 0.5 µM TRI and 2.75 µM TEB + 1.0 µM TRI) solely and in combination with NaCl (60 mM) for six days. The application of salt phenotypically deteriorated the cucumber plant growth that caused yellowing of the whole plant and significantly destructed the contents of chlorophyll and carotenoids. The oxidative damage was created under salinity by increasing the contents of malondialdehyde (MDA), hydrogen peroxide (H2O2), and electrolytic leakage (EL) resulting in the disruption of the antioxidant defense system. Furthermore, in the leaves, stems, and roots of cucumber plants increased Na+ content was observed under salt stress, whereas the K+/Na+ ratio and contents of K+, Ca2+, and Mg2+ decreased. In contrast, the exogenous application of TEB and TRI reduced the contents of MDA, H2O2, and EL by improving the activities of enzymatic and non-enzymatic antioxidants. In addition, ion homeostasis was regulated by reducing Na+ uptake and enhanced K+ accumulation and the K+/Na+ ratio after application of TEB and TRI. Therefore, this study indicates that the exogenous application of TEB and TRI enhanced salt tolerance in cucumber plants by regulating reactive oxygen species production and antioxidant defense systems.
Comparison of manual and automated auscultatory blood pressure during graded exercise among people with type 2 diabetes

Manual measurement of blood pressure (BP) during exercise testing is the recommended standard. Automated measurement of BP is an alternative method used during clinical exercise testing, but there is little data comparing manual and automated BP in this setting. The aim of this study was to determine the concordance between manual and automated BP during a standard clinical treadmill exercise test. 416 participants (66 ± 5 years; 54% male) completed a Bruce treadmill exercise test at baseline or follow‐up within a clinical trial of participants with type 2 diabetes mellitus. Manual and automated BP were measured simultaneously at each exercise test stage. Manual BP was measured by a technician blinded to automated BP values (Tango+, Suntech). Concordance between manual and automated BP was assessed using mean differences and intraclass correlations (ICC). Concordance between manual and automated BP across all exercise stages was excellent for systolic BP (overall mean difference: 3 ± 11 mm Hg, P = .598; ICC = 0.964 [95% CI 0.942‐0.977] and pulse pressure (overall mean difference: 2 ± 14 mm Hg, P = .595; ICC = 0.934 [95% CI 0.899‐0.956]). Concordance between manual and automated diastolic BP across all exercise stages was moderate‐to‐good (overall mean difference: 1 ± 9 mm Hg, P = .905; ICC = 0.784 [95% CI 0.672‐0.858]). Automated BP using the Tango + device is concordant with manual BP during early stages of a standard clinical exercise test. Thus, this automated method may be a suitable alternative to manual measurement of BP during clinical exercise testing.
Modulation of the pupillary response by the content of visual working memory

Significance We report, across 3 complementary studies, that attention in visual working memory leads to top-down modulations of the pupillary response, in the absence of any visual input or anticipation of any change in brightness. These findings strengthen the view of the sensory recruitment, all the way down to the earliest synapses in the visual system. The thought-provoking corollary to our findings is that the pupils provide a reliable measure of what is in the focus of the mind. Studies of selective attention during perception have revealed modulation of the pupillary response according to the brightness of task-relevant (attended) vs. -irrelevant (unattended) stimuli within a visual display. As a strong test of top-down modulation of the pupil response by selective attention, we asked whether changes in pupil diameter follow internal shifts of attention to memoranda of visual stimuli of different brightness maintained in working memory, in the absence of any visual stimulation. Across 3 studies, we reveal dilation of the pupil when participants orient attention to the memorandum of a dark grating relative to that of a bright grating. The effect occurs even when the attention-orienting cue is independent of stimulus brightness, and even when stimulus brightness is merely incidental and not required for the working-memory task of judging stimulus orientation. Furthermore, relative dilation and constriction of the pupil occurred dynamically and followed the changing temporal expectation that 1 or the other stimulus would be probed across the retention delay. The results provide surprising and consistent evidence that pupil responses are under top-down control by cognitive factors, even when there is no direct adaptive gain for such modulation, since no visual stimuli were presented or anticipated. The results also strengthen the view of sensory recruitment during working memory, suggesting even activation of sensory receptors. The thought-provoking corollary to our findings is that the pupils provide a reliable measure of what is in the focus of mind, thus giving a different meaning to old proverbs about the eyes being a window to the mind.
The Phenomenon of the Apparent (Double) Femoral Head in Infant Hip Sonography According to Graf-Description, Incidence and Clinical Relevance Das Phänomen des scheinbar (ver)doppelten Hüftkopfes bei der Säuglingssonografie nach Graf-Beschreibung, Inzidenz und klinische Relevanz

Abstract Purpose Hip screening sonography according to Graf in rare cases yields the appearance of a double femoral head, aptly named the Double-Head-Sign. The goal of this retrospective study is to offer a definition of this rare sign, evaluate its incidence of occurrence and compare the sonographic findings with the clinical findings. Materials and Methods This Double-Head-Sign is caused by the overlap of the trochanter major with the actual head of the femur in cases of coxa vara. This was observed in 13 of 2800 neonates we screened as part of our sonographical neonatal hip screening. Results 13 neonates presented themselves with ultrasound findings in accordance with our description, yielding an incidence of 0,46% in our patient cohort. In correlation, these neonates also exhibited increased external and decreased internal rotation of the hip. Two had an underlying condition (achondroplasia). Conclusion In these rare cases, clinical examination of hip rotation in 90° hip flexion has proved helpful and further interdisciplinary examination of such infants to distinguish a possible underlying primary condition is recommended Zusammenfassung Einleitung Das sonografische Hüftscreening nach Graf zeigt in seltenen Fällen das Phänomen des scheinbar (ver)doppelten Hüftkopfes. Das Ziel dieser retrospektiven Studie ist es, eine Definition zu finden, die Inzidenz des Auftretens darzulegen und die klinischen mit den sonografischen Untersuchungsbefunden zu vergleichen. Material und Methoden Das Phänomen des scheinbar (ver)doppelten Hüftkopfes wird verursacht durch das Überlappen des Trochanter major mit dem Femurkopf bei Coxa vara und verminderter Antetorsion. Im Rahmen des leitliniengerechten Neugeborenenscreenings wurden 2017 – 2018 2800 Säuglinge untersucht, dabei kam es in 13 Fällen zu dem oben beschriebenen sonografischen Befund. Ergebnisse Von den 2800 untersuchten Neugeborenen zeigte sich bei 13 Kindern das Phänomen des scheinbar (ver)doppelten Hüftkopfes im Ultraschall. Dies entspricht einer Inzidenz von 0,46%. Klinisch zeigten sich bei diesen Patienten eine abnormal vermehrte Außenrotation und verminderte Innenrotation der Hüften in 90° Hüftbeugung. 11 der 13 Kinder zeigten sich in der weiterführenden pädiatrischen und orthopädischen Untersuchung als unauffällig. Bei 2 Kindern wurde eine Achondroplasie diagnostiziert. Es befand sich ein Zwillingskind unter den 13 Kindern. Schlussfolgerung Das Phänomen des scheinbar (ver)doppelten Hüftkopfes kann in der Routineuntersuchung beim Hüftscreening nach Graf festgestellt werden. Dies kann ein Hinweis auf eine Coxa vara sein. Eine weitere Abklärung ist empfohlen, um eine Grunderkrankung auszuschließen.
Complex patterns of dopamine‐related gene expression in the ventral tegmental area of male zebra finches relate to dyadic interactions with long‐term female partners

Dopaminergic projections from the ventral tegmental area (VTA) to multiple efferent targets are implicated in pair bonding, yet the role of the VTA in the maintenance of long‐term pair bonds is not well characterized. Complex interactions between numerous neuromodulators modify activity in the VTA, suggesting that individual differences in patterns of gene expression in this region may explain individual differences in long‐term social interactions in bonded pairs. To test this hypothesis we used RNA‐seq to measure expression of over 8000 annotated genes in male zebra finches in established male‐female pairs. Weighted gene co‐expression network analysis identified a gene module that contained numerous dopamine‐related genes with TH found to be the most connected gene of the module. Genes in this module related to male agonistic behaviors as well as bonding‐related behaviors produced by female partners. Unsupervised learning approaches identified two groups of males that differed with respect to expression of numerous genes. Enrichment analyses showed that many dopamine‐related genes and modulators differed between these groups, including dopamine receptors, synthetic and degradative enzymes, the avian dopamine transporter and several GABA‐ and glutamate‐related genes. Many of the bonding‐related behaviors closely associated with VTA gene expression in the two male groups were produced by the male's partner, rather than the male himself. Collectively, results highlight numerous candidate genes in the VTA that can be explored in future studies and raise the possibility that the molecular/genetic organization of the VTA may be strongly shaped by a social partner and/or the strength of the pair bond.
Two metabolites isolated from endophytic fungus Coniochaeta sp. F-8 in Ageratina adenophora exhibit antioxidative activity and cytotoxicity

Abstract Ageratina adenophora is an invasive plant of global importance and has a broad distribution in the Western Himalayas. Endophtytic fungus Coniochaeta sp.F-8 was found in Ageratina adenophora. In this paper, we aim to investigate the antioxidative activity and cytotoxicity of the metabolites from Coniochaeta sp.F-8. Consequently, two compounds Phomoxanthone A and Penialidin A were isolated from the endophytic fungus of Ageratina adenophora for the first time. The structures of compounds were identified by IR, NMR and ESI-MS methods. Moreover, both of those compounds showed considerable antioxidative activity in vitro and resulted cytotoxicity in mouse embryo fibroblasts cell line Balb/c3T3. The present study provides a theoretical foundation for the development and utilization of endophytic fungi in Ageratina adenophora as a medicinal substance. Graphical Abstract
Covariation between forelimb muscle anatomy and bone shape in an Australian scratch‐digging marsupial: Comparison of morphometric methods

The close association between muscle and bone is broadly intuitive; however, details of the covariation between the two has not been comprehensively studied. Without quantitative understanding of how muscle anatomy influences bone shape, it is difficult to draw conclusions of the significance of many morphological traits of the skeleton. In this study, we investigated these relationships in the Quenda (Isoodon fusciventer), a scratch‐digging marsupial. We quantified the relationships between forelimb muscle anatomy and bone shape for animals representing a range of body masses (124–1,952 g) using two‐block partial least square analyses. Muscle anatomy was quantified as muscle mass and physiological cross‐sectional area (PCSA), and we used two morphometric methods to characterize bone shape: seven indices of linear bone proportions, and landmarks analysis. Bone shape was significantly correlated with body mass, reflecting allometric bone growth. Of the seven bone indices, only shoulder moment index (SMI) and ulna robustness index (URI) showed a significant covariation with muscle anatomy. Stronger relationships between muscle anatomy and forelimb bone shape were found using the landmark coordinates: muscle mass and PCSA were correlated with the geometric shape of the scapula, humerus, and third metacarpal, but to a lesser extent with shape of the ulna. Overall, our data show that landmark coordinates are more sensitive than bone indices to capturing shape changes evident throughout ontogeny, and is therefore a more appropriate method to investigate covariation with forelimb muscle anatomy. Single‐species studies investigating ontogeny require refined methods to accurately develop understanding of the important relationships between muscle force generation and bone shape remodeling. Landmark analyses provide such a method.
A comparison study of three physical activity measurement tools examining acceptability in people with psychosis

Objective: To compare the acceptability of three distinct physical activity measurement tools in people with psychosis: an objective measurement tool, a self-report measure, and an exercise capacity test. Methods: We measured the completion rate for each measurement tool. Participants rated the ease/difficulty of each measure using a 7-point Likert scale. Participants were also asked to rank the three tools in order of the ease of use. Results: Sixty-six per cent (46/69) of participants completed all three assessment tools, and 60.9% (42/69) completed the acceptability questionnaire. The majority of the participants found it easy to complete all three measurement tools. The majority (52.8%) of the participants ranked the objective measurement tool as the easiest to use. Conclusion: All three measures were acceptable to people with psychosis, but objective measurement tools may be easier to use.
The Chd1 chromatin remodeler forms long-lived complexes with nucleosomes in the presence of ADP·BeF3− and transition state analogs

Chromatin remodelers use helicase-like ATPase domains to reorganize histone–DNA contacts within the nucleosome. Like other remodelers, the chromodomain helicase DNA-binding protein 1 (Chd1) remodeler repositions nucleosomes by altering DNA topology at its internal binding site on the nucleosome, coupling different degrees of DNA twist and DNA movement to distinct nucleotide-bound states of the ATPase motor. In this work, we used a competition assay to study how variations in the bound nucleotide, Chd1, and the nucleosome substrate affect stability of Chd1–nucleosome complexes. We found that Chd1–nucleosome complexes formed in nucleotide-free or ADP conditions were relatively unstable and dissociated within 30 s, whereas those with the nonhydrolyzable ATP analog AMP-PNP had a mean lifetime of 4.8 ± 0.7 min. Chd1–nucleosome complexes were remarkably stable with ADP·BeF3− and the transition state analogs ADP·AlFX and ADP·MgFX, being resistant to competitor nucleosome over a 24-h period. For the tight ADP·BeF3−–stabilized complex, Mg2+ was a critical component that did not freely exchange, and formation of these long-lived complexes had a slow, concentration-dependent step. The ADP·BeF3−–stabilized complex did not require the Chd1 DNA-binding domain nor the histone H4 tail and appeared relatively insensitive to sequence differences on either side of the Widom 601 sequence. Interestingly, the complex remained stable in ADP·BeF3− even when nucleosomes contained single-stranded gaps that disrupted most DNA contacts with the guide strand. This finding suggests that binding via the tracking strand alone is sufficient for stabilizing the complex in a hydrolysis-competent state.