Miracle-dz/UniFAR-FTUs huggingface dataset:
Transforming Growth Factor- b 1 Recruits Histone Deacetylase 1 to a p130 Repressor Complex in Transgenic Mice in Vivo 1

Transforming growth factor (TGF)- b 1 functions as a tumor suppressor in vivo . Using transgenic mice, we show that hepatic TGF- b 1 overexpression inhibits abundance of the cyclin-dependent kinase activating tyrosine phosphatase cdc25A protein. The reduction in cdc25A protein levels was associated with increased binding of histone deacetylase 1 to p130 in the hepatic extracts. In cultured cells, HDAC1/p130 overexpression inhibited activity of the cdc25A promoter through an E2F site. TGF- b 1 treatment enhanced p130 binding to the cdc25A promoter E2F site assessed in chromatin immunoprecipitation assays. Hepatic proliferation induced by partial hepatectomy was associated with a decrease in the amount of HDAC1 bound to p130, without a significant decrease in p130 abundance, suggesting that HDAC1 binding to p130 may be regulated by proliferative stimuli. The induction of cdc25A abundance induced by partial hepatec- tomy correlated with the induction of DNA synthesis. These studies suggest that TGF- b 1 may enhance HDAC1 binding to p130 in vivo , thereby inhibiting cdc25A gene expression. TGF- b 1 regulation of HDAC1/pocket protein associations may provide a link between chromatin remodeling proteins and cdk inhibition through induction of cdc25A in vivo .
EXAMINATION OF AROMA PRODUCTION KINETICS OF DIFFERENT COMMERCIAL WINE YEASTS IN FERMENTING MUSCAT OTTONEL WINES WITH THE HELP OF SPME HEAD-SPACE SAMPLING AND FAST GC ANALYSIS

Solid phase microextraction (SPME) coupled to fast capillary gas chromatography was used for monitoring the wine fermentation process. This combination offers a simple, quick and sensitive approach suitable for characterization of head-space components of wines during the fermentation process without a complicated sample preparation procedure. In this work this method was used to observe the differences in aroma production between three different commercial yeasts and the indigenous yeast flora.
Research of Dynamic Access to Cloud Database Based on Improved Pheromone Algorithm

In cloud computing environments, the database is dynamic and real-time features, and in data access it has been a Gordian knot of cloud computing research; because in the ant colony algorithm that ants finding food shares similar correlation with cloud computing node finding the access to the database. Therefore, the introduction of ant colony algorithm into cloud computing database, the introduction of the chaos function in the pheromone update, both will make the improved pheromone avoid the possibility of getting into local convergence, and hence improve the efficiency of database access in the cloud computing, reduce the load in the cloud computing. The simulation results show that the algorithm in this paper has been significantly improved in terms of cloud computing network queries and database consumption, and greatly improved the efficiency of cloud computing.
Uptake of HNO3 to deliquescent sea-salt particles: a study using the short-lived radioactive isotope tracer 13N

The uptake of HNO 3 to deliquescent airborne sea-salt particles (RH = 55%, P = 760 torr, T = 300 K) at concentrations from 2 to 575 ppbv is measured in an aerosol ﬂow tube using 13 N as a tracer. Small particles ( ≈ 70 nm diameter) are used in order to minimize the effect of diffusion in the gas phase on the mass transfer. Below 100 ppbv, an uptake coefﬁcient ( γ upt ) of 0.50 ± 0.20 is derived. At higher concentrations, the uptake coefﬁcient decreases along with the consumption of aerosol chloride. Data interpretation is further supported by using the North American Aerosol Inorganics Model (AIM), which predicts the aqueous phase activities of ions and the gas-phase partial pressures of H 2 O, HNO 3 , and HCl at equilibrium for the NaCl/HNO 3 /H 2 O system. These simulations show that the low concentration data are obtained far from equilibrium, which implies that the uptake coefﬁcient derived is equal to the mass accommodation coefﬁcient under these conditions. The observed uptake coefﬁcient can serve as input to modeling studies of atmospheric sea-salt aerosol chemistry. The main sea-salt
Current State of Art of Energy Efficient PEGASIS Routing Protocols in WSNs

Wireless sensor network is an ad-hoc network that consists of small nodes with sensing, computing and communicating wireless abilities and these sensor nodes communicate with each other via various Routing Protocols. The essential challenging factors in the design of routing protocols in WSNs must be overcome in order to have an efficient transmission in a wireless sensor network.Researchers have designed and improvised different routing protocols to overcome factors such as, to maximize the network lifetime, balance energy consumption without losing accuracy, increase throughput of the network, power management, multi-hop transmission etc. Amongst these, energy conservation is a critical design issue. Hence, this article reviews and compares the improved versions of Power- Efficient Gathering in Sensor Information Systems (PEGASIS) protocol to achieve prolong communication in a wireless sensor network with minimal energy consumption.
THE NOTIONS OF ENGLISH LANGUAGE AND RESEARCH INSTRUCTORS ON THE IMPACT OF DIGITAL TECHNOLOGIES ON THE RESEARCH WRITING PROCESS OF THEIR COLLEGE STUDENTS

This is a descriptive study investigating teachers’ view on the impact of digital technologies on the research writing of their students. Using Mishra and Koehler’s (2006) TPCK model as framework, a probe was made on how technology and content are related and how pedagogical strategies in research relates to the use of technology in the classroom. The results reveal that teachers generally viewed the impact of digital technologies as positive but also showed misgivings on some aspects of technology use. The results have significant impact on the ICT policy currently being implemented in most state-run schools in the Philippines. Keywords: digital technologies, teacher perceptions, college research, ICT policy
A Flexible Microelectrode Array for Recording Signals of Culturing DRG Explants

Owning to the advanced technology of microelectromechanical systems (MEMS), more and more precise microelectrode arrays are used to serve as neural prosthesis. Peripheral nerve injury and amputation have plagued neurosurgeons and patients. Neural interface have been served as a bridge between peripheral nerves and prosthetic limbs. In this study, to characterize the signals of culturing dorsal root ganglion (DRG) explants, a flexible electronic microelectrode arrays using SU-8 was designed to serve as neural interface to record neural signals of culturing DRG explants. The arrays are composed of thin gold electrode on a flexible material called SU-8, The materials and methods will play an important role in recording neural signals of culturing DRG explants. The goal of this study is to design an artificial limb that the amputees could control as if it was a natural extension of their own body.
Toward Conceptualizing Perplexity in Cybersecurity: An Toward Conceptualizing Perplexity in Cybersecurity: An Exploratory Study Exploratory Study

As cybersecurity threats evolve and cybersecurity teams update digital security infrastructures, employees often get perplexed by the threats and corresponding countermeasures. Drawing insight from a literature review and a qualitative exploratory study with 85 participants, this paper defines cybersecurity perplexity, a paradoxical psychological state that individuals experience when facing adverse cybersecurity conditions in the workplace (e.g., ambiguous or surprising security policies or awareness of cybersecurity threats). Cybersecurity perplexity has three interrelated dimensions: cybersecurity confusion, cybersecurity pressure, and cybersecurity response uncertainty. Central to cybersecurity perplexity is that individuals are confused and uncertain about how to respond, yet feel pressure to act, to adverse cybersecurity conditions. Our data suggests that perplexity merits researchers’ attention because it can arise from myriad cybersecurity conditions that individuals frequently
Variation of UPFC controllable parameters during power swing and their impacts on distance relay

Unified power flow controller (UPFC) has impact on the performance of distance relay during power swing. Generally, power system's parameters oscillate during power swing and since UPFC operation depends on some of these parameters (bus voltage, active and reactive power), the UPFC injects oscillated series voltage and draws oscillated shunt current. These oscillating series voltage and shunt current influence distance relays, as the impedance seen by a distance relay during power swing changes in UPFC-compensated lines. This study shows how and why series voltage and shunt current change during power swing. Moreover, the admittance swing characteristic is proposed in this study and effects of series and shunt branches of UPFC on the admittance seen by a distance relay during power swing have been examined.
We Are All In This Together: The Impact of Collaborative Professional Learning Teams on 21st Century Literacy Instruction

iv ACKNOWLEDGEMENTS . v LIST OF TABLES . xiii CHAPTER ONE: INTRODUCTION . 1 Rationale of the Study . 13 CHAPTER TWO: LITERATURE REVIEW . 18 Theories of Adult Learning . 18 Age and Stage Theories . 18 Cognitive Theories . 19 Observations of Adult Learning . 21 History of Collaboration . 25 Learning Organizations . 29 Systems Thinking . 31 Professional Learning Communities (PLCs) . 35 School Reform . 37 Social Participation . 38 Key Traits of Learning Communities . 41 Environmental Considerations . 44 Alignment . 45 CHAPTER THREE: METHODOLOGY . 49 Introduction . 49 Context . 50
Association between viral hepatitis and increased risk of severe coronavirus disease 2019 (COVID-19) outcome: a systematic review and meta-analysis

Aim: The purpose of the current study is to analyze the potential association between viral hepatitis and the severity of COVID-19. Background: Coronavirus disease 2019 (COVID-19) is a worldwide concern that has created major issues with many aspects. It is important to identify the risk factors for severe outcomes of this disease. To date, no association between viral hepatitis and severe COVID-19 has not been established. Methods: Through November 5th, 2020, the databases of PubMed, Google Scholar, and medRxiv were systematically searched using specific keywords related to the focus of the study. All articles published on COVID-19 and viral hepatitis were retrieved. The Mantel-Haenszel formula with random-effects models was used to obtain the risk ratio (RR) along with its 95% confidence intervals (CIs) for dichotomous variables. The two-tailed p-value was set with a value ≤0.05 considered statistically significant. Restricted-maximum likelihood meta-regression was done for several variables, such as age, gender, hypertension, diabetes, and other liver disease. Results Analysis results included a total of 16 studies with a total of 14,682 patients. Meta-analysis showed that viral hepatitis increases the risk of developing severe COVID-19 (RR 1.68 (95% CI 1.26 – 2.22), p = 0.0003, I2 = 21%, random-effect modeling). According to the meta-regression analysis, the association between viral hepatitis and severe COVID-19 was not influenced by age (p = 0.067), diabetes (p = 0.057), or other liver disease (p = 0.646). Conclusion: An increase of severe COVID-19 risk is associated with viral hepatitis. To reduce the risk of COVID-19, patients with viral hepatitis should be monitored carefully.
WNT11, a new gene associated with early onset osteoporosis, is required for osteoblastogenesis

Abstract Monogenic early onset osteoporosis (EOOP) is a rare disease defined by low bone mineral density (BMD) that results in increased risk of fracture in children and young adults. Although several causative genes have been identified, some of the EOOP causation remains unresolved. Whole-exome sequencing revealed a de novo heterozygous loss-of-function mutation in Wnt family member 11 (WNT11) (NM_004626.2:c.677_678dup p.Leu227Glyfs*22) in a 4-year-old boy with low BMD and fractures. We identified two heterozygous WNT11 missense variants (NM_004626.2:c.217G > A p.Ala73Thr) and (NM_004626.2:c.865G > A p.Val289Met) in a 51-year-old woman and in a 61-year-old woman, respectively, both with bone fragility. U2OS cells with heterozygous WNT11 mutation (NM_004626.2:c.690_721delfs*40) generated by CRISPR-Cas9 showed reduced cell proliferation (30%) and osteoblast differentiation (80%) as compared with wild-type U2OS cells. The expression of genes in the Wnt canonical and non-canonical pathways was inhibited in these mutant cells, but recombinant WNT11 treatment rescued the expression of Wnt pathway target genes. Furthermore, the expression of RSPO2, a WNT11 target involved in bone cell differentiation, and its receptor leucine-rich repeat containing G protein-coupled receptor 5 (LGR5), was decreased in WNT11 mutant cells. Treatment with WNT5A and WNT11 recombinant proteins reversed LGR5 expression, but Wnt family member 3A (WNT3A) recombinant protein treatment had no effect on LGR5 expression in mutant cells. Moreover, treatment with recombinant RSPO2 but not WNT11 or WNT3A activated the canonical pathway in mutant cells. In conclusion, we have identified WNT11 as a new gene responsible for EOOP, with loss-of-function variant inhibiting bone formation via Wnt canonical and non-canonical pathways. WNT11 may activate Wnt signaling by inducing the RSPO2–LGR5 complex via the non-canonical Wnt pathway.
Perceptual evaluation of discretization and interpolation for motion-tracked binaural (MTB) recordings (Perzeptive Evaluation von Diskretisierungs- und Interpolationsansätzen für 'motion-tracked binaural' (MTB-)Aufnahmen)

In 2004, motion-tracked binaural (MTB) sound was introduced as a new method for capturing, recording, and reproducing spatial sound. MTB uses a circular array of microphones on a rigid sphere with the diameter of an average head. Recordings are played back via headphones while tracking the listener’s head movements in the horizontal plane. We conducted a listening test with 26 subjects assessing the reproduction’s plausibility. Using a MUSHRA-like comparative test paradigm we tested the effect of the number of microphones (8, 16, 24, 32), interpolation scheme (5 methods), and audio content (noise, music, speech). Although there was a clearly superior configuration, the plausibility of MTB reproduction was found to be highly interdependent on all three parameters. In the context of virtual acoustic environments (VAEs) immersive recordings of ambient sounds are becoming more relevant. The ‘acoustic atmosphere’ of VAEs suffers from a lack of naturalism as typically the sound from a surrounding audience, nature events or sounds of technical origin (traffic, HVAC) – which one would expect to occur in reality – are not rendered. Thus, listeners sporadically complain about an ‘aseptic feel’ of the acoustic simulation. Moreover, in a recent study [1], indications for the particular relevance of social and emotional aspects for the experience of live music performances were found. An authentic simulation of environmental noise – of both natural and technical origin – might thus increase perceived realism of VAEs. With common approaches to holophonic sound field reproduction, as for instance wave field synthesis (WFS) and higher-order Ambisonics (HOA) [2], the physically authentic reproduction of arbitrary ambient sound fields over extended listening areas would require densely spaced microphone and loudspeaker arrays. Therefore, the costs to render acoustic sceneries or ‘soundscapes’ in an ecologically valid manner would be considerable. For WFS an approach to represent ambient scenes aiming primarily at plausibility than at physical
Using High-level Synthesis to Predict and Preempt Attacks on Industrial Control Systems

As the rate and severity of malicious software attacks have escalated, industrial control systems (ICSes) have emerged as a particularly vulnerable target. ICSes govern the automation of the physical processes in industries such as power, water, oil and manufacturing. In contrast to the personal computing space, where attackers attempt to capture information or computing resources, the attacks directed at ICSes aim to degrade or destroy the physical processes or plants maintained by the ICS. Exploits with potentially catastrophic results are sold on brokerages to any interested party. Previous efforts in ICS security implicitly and mistakenly trust internal software. This thesis presents an architecture for trust enhancement of critical embedded processes (TECEP). TECEP assumes that all software can be or has already been compromised. Trust is instead placed in hardware that is invisible to any malicious software. Software processes critical for stable operation are duplicated in hardware, along with a supervisory process to monitor the behavior of the plant. Furthermore, a copy of the software and a model of the plant are implemented in hardware in order to estimate the system’s future behavior. In the event of an attack, the hardware can successfully identify the plant’s abnormal behavior in either the present or the future and supersede the software’s directives, allowing the plant to continue functioning correctly. This approach to ICS security can be retrofitted to existing ICSes, has minimal impact on the ICS design process, and modestly increases hardware requirements in a programmable system-on-chip.
Structural Rehabilitation Analyses for a Romanian Cultural Heritage Building Located in Seismic Area

Structural rehabilitation, especially of historical monuments, is a difficult and widely treated subject in order to achieve a better insight regarding their seismic response. In Romania, a lot of historical monuments that require rehabilitation due to seismic actions are encountered. This paper aims to assess the effects of structural retrofitting on a historical monument located in Botoşani County, which withstood during its life cycle important earthquakes. The 20th century monument is located in a seismic active area of North – Eastern Romania, at a distance less than 300 km from Vrancea region where the epicenter of major earthquakes for the Eastern Europe is situated. Two hypotheses for the FE model of the structure were considered, namely with and without the rehabilitation solution. Nonlinear FEM analyses were performed in computer software environments. Using specific modeling tools of the computer program it is intended to simulate linear behaviour of masonry and global response of the structure. Comparisons between the two models were made. The results are used to validate the rehabilitation solution also consisting a source of information for its effects during structural lifetime cycle of the historical church.
Effects of isolation trench depth on bulk integrated quenching resistors and breakdown voltage of the silicon photomultiplier with bulk integrated quenching resistors

Much attention has been paid to silicon photomultiplier (SiPM) for single photon resolution. The New Devices Laboratory, Beijing Normal University developed a SiPM with bulk integrated quenching resistors, which has simple, compact structure, can achieve high dynamic range. This paper presents a bulk resistor type SiPM with trenches isolation. The effects of the trench depth on quenching bulk resistors and breakdown voltage are studied by simulation. The bulk quenching resistors and breakdown voltage can be adjusted by the depth of the isolation trench when the wafer resistivity is high. The results are important for the design of the bulk resistors quenching SiPM.
Design Mobile Application of Marriage Counseling onthe Catholic Church with UCD and Wireframe Method

The mobile application is an application that is growing very rapidly and gains broad market. One of its advantages is practical and easy to use everywhere. Although its development is quite rapid,its applications in the field of consultationis limited, especially in the field of consultation services organized by the Catholic Church. This paper describes how to design mobile application counseling for the Catholic Church using User Centered Design (UCD) and Wireframe. The scope of the consultation material is about the marriage preparations. The research is conducted on marriage preparation classes in one of the Catholic Churches in Yogyakarta. The results of the study, that is analyzed using ISO standardwith score average 4.425 andSystem Usability Scale (SUS) evaluation method with totalscore 82 showed that this study succeeded in designing a mobile application marriage counseling in the Catholic Church is consistent with user needs
Assessing the Effects of Rising Groundwater from Sea Level Rise on the Service Life of Pavements in Coastal Road Infrastructure

Coastal communities with road infrastructure close to the shoreline are vulnerable to the effects of sea level rise caused by climate change. The sea level in coastal New Hampshire is projected to rise by 3.9 to 6.6 ft (1.2 to 2.0 m) by 2100. Climate change vulnerability and adaptation studies have focused on surface water flooding caused by sea level rise; however, little attention has been given to the effects of climate change on groundwater. Groundwater is expected to rise with sea level rise and will intersect the unbound layers of coastal road infrastructure, thus reducing the service life of pavement. Vulnerability studies are an essential part of adaptation planning, and pavement engineers are looking for methods to identify roads that may experience premature failure. In this study, a regional groundwater flow model of coastal New Hampshire was used to identify road infrastructure for which rising groundwater will move into the unbound materials during the design life of the pavement. Multilayer elastic theory was used to analyze typical pavement profiles in several functional classifications of roadway to determine the magnitude of fatigue and rutting life reduction expected from four scenarios of sea level rise. All the evaluation sites experienced service life reduction, the magnitude and timing of which depended on the current depth to groundwater, the pavement structure, and the subgrade. The use of this methodology will enable pavement engineers to target coastal road adaptation projects effectively and will result in significant cost savings compared with implementation of broad adaptation projects or the costs of no action.
Lung cell toxicity of co-exposure to airborne particulate matter and extremely low-frequency magnetic field

Abstract Although the toxic effects of urban airborne particulate matter (PM) have been known on lung cells, there is less attention to co-exposure to PM and extremely low frequency magnetic (ELF-MF) in occupational settings. The present study investigated the influences of PM and ELF-MF co-exposure on toxicity in human lung cells (A549). In this case, total PM (TPM) was evaluated according to NIOSH-0500. The TPM SiO2 and metal contents were determined based on NIOSH-7602 and 7302, respectively. Besides, 900 mG ELF-MF exposure was simulated based on field measurements. The toxicity mechanisms were assessed by examining malondialdehyde, glutathione ratio, gene expression, and DNA strand breaks. Also, the toxicity indicators of the TPM samples were MDA generation, glutathione depletion, and DNA damage, and their impacts were analysed at doses below the LD50 (4 µg). In addition, gene expression of OGG1 and MTH1 was upregulated after TPM exposure at the lowest dose (2 µg). But ITPA was upregulated in the presence of ELF-MF. The co-exposure to TPM and ELF-MF decreased oxidative stress and DNA damage levels compared to a single exposure to TPM. Although the ELF-MF reduced toxicity in response to TPM, this reduction was not lower than the unexposed cells.