Miracle-dz/UniFAR-FTUs huggingface dataset:
Bipolar Analog Memristors as Artificial Synapses for Neuromorphic Computing

Synaptic devices with bipolar analog resistive switching behavior are the building blocks for memristor-based neuromorphic computing. In this work, a fully complementary metal-oxide semiconductor (CMOS)-compatible, forming-free, and non-filamentary memristive device (Pd/Al2O3/TaOx/Ta) with bipolar analog switching behavior is reported as an artificial synapse for neuromorphic computing. Synaptic functions, including long-term potentiation/depression, paired-pulse facilitation (PPF), and spike-timing-dependent plasticity (STDP), are implemented based on this device; the switching energy is around 50 pJ per spike. Furthermore, for applications in artificial neural networks (ANN), determined target conductance states with little deviation (<1%) can be obtained with random initial states. However, the device shows non-linear conductance change characteristics, and a nearly linear conductance change behavior is obtained by optimizing the training scheme. Based on these results, the device is a promising emulator for biology synapses, which could be of great benefit to memristor-based neuromorphic computing.
Partial Purification, Identification, and Quantitation of Antioxidants from Wild Rice (Zizania latifolia)

To provide further insights into the potential health-promoting antioxidants from wild rice (Zizania latifolia), which is an abundant but underutilized whole grain resource in East Asia, a partial purification based on D101 macroporous resin was carried out for the purification and enrichment of the antioxidants from the bioactive ethanol extracts of wild rice. On that basis, 34 phenolic compounds in the antioxidant fractions were identified by a high-performance liquid chromatography-linear ion trap quadrupole-Orbitrap-mass spectrometry (HPLC-LTQ-Orbitrap-MSn). The results suggested that phenolic acids could be enriched in the 10% ethanol-eluted fraction whereas flavonoids (including procyanidins and flavonoid glycosides) could be enriched in 20–30% ethanol-eluted fractions. A quantitative analysis determined by the multiple reaction monitoring mode of the ultra-performance liquid chromatography-triple quadrupole-tandem mass spectrometry (UPLC-QqQ-MS/MS) revealed a high content of procyanidins in wild rice. Compared with phenolic acids, flavonoids may contribute more to the potent antioxidant activity of wild rice. This is the first study on the antioxidants from wild rice Z. latifolia. These findings provide novel information on the functional components of wild rice, and will be of value to further research and development on Z. latifolia.
Poor clinical outcomes associated with community-onset urinary tract infections due to extended-spectrum cephalosporin-resistant Enterobacteriaceae

Abstract Objective Resistance to extended-spectrum cephalosporins (ESC) among Enterobacteriaceae (EB) is increasingly prevalent. We sought to determine the clinical outcomes associated with community-onset ESC-resistant (ESC-R) EB urinary tract infections (UTIs) in a US health system. Design Retrospective cohort study. Patients All patients presenting to the emergency departments (EDs) or outpatient practices with EB UTIs between 2010 and 2013 were included. Exposed patients had ESC-R EB UTIs. Unexposed patients had ESC-susceptible EB UTIs and were matched to exposed subjects 1:1 on study year. Multivariable logistic regression analyses were performed to evaluate the association between ESC-R EB UTI and the outcomes of clinical failure and inappropriate initial antibiotic therapy (IIAT). Results A total of 302 patients with community-onset EB UTI were included, with 151 exposed and unexposed. On multivariable analyses, UTI due to an ESC-R EB was significantly associated with clinical failure (odds ratio [OR], 7.07; 95% confidence interval [CI], 3.16–15.82; P<.01). Other independent risk factors for clinical failure included infection with Citrobacter spp and need for hemodialysis. UTI due to an ESC-R EB was also significantly associated with IIAT (OR, 4.40; 95% CI, 2.64–7.33; P<.01). Conclusions Community-onset UTI due to an ESC-R EB organism is significantly associated with clinical failure, which may be due in part to IIAT. Further studies are needed to determine which patients in the community are at high risk for drug-resistant infection to help inform prompt diagnosis and appropriate antibiotic prescribing for ESC-R EB.
Learning Cross-Lingual Sentence Representations via a Multi-task Dual-Encoder Model

A significant roadblock in multilingual neural language modeling is the lack of labeled non-English data. One potential method for overcoming this issue is learning cross-lingual text representations that can be used to transfer the performance from training on English tasks to non-English tasks, despite little to no task-specific non-English data. In this paper, we explore a natural setup for learning cross-lingual sentence representations: the dual-encoder. We provide a comprehensive evaluation of our cross-lingual representations on a number of monolingual, cross-lingual, and zero-shot/few-shot learning tasks, and also give an analysis of different learned cross-lingual embedding spaces.
Towards Intention Prediction for Handheld Robots: a Case of Simulated Block Copying

Within this work, we explore intention inference for user actions in the context of a handheld robot setup. Handheld robots share the shape and properties of handheld tools while being able to process task information and aid manipulation. Here, we propose an intention prediction model to enhance cooperative task solving. Within a block copy task, we collect eye gaze data using a robot-mounted remote eye tracker which is used to create a profile of visual attention for task-relevant objects in the workspace scene. These profiles are used to make predictions about user actions i.e. which block will be picked up next and where it will be placed. Our results show that our proposed model can predict user actions well in advance with an accuracy of 87.94% (500ms prior) for picking and 93.25% (1500 ms prior) for placing actions.
Gender differences in concussion-related knowledge, attitudes and reporting-behaviours among high school student-athletes

Abstract Background/aim Sport-related concussion is associated with various short- and long-term health consequences, especially among adolescent athletes. Yet, many concussions go unreported and/or unrecognised. The purpose of this study was to assess high school athletes’ concussion-related knowledge, attitudes, intentions and reporting behaviours, and to explore whether gender differences are evident. Methods A total of 435 high school athletes (52.2% female; mean age, 14.55 ± 1.67 years) participated in the survey. Questions assessed athletes’ knowledge, attitudes, reporting intention and reporting behaviours, in respect to sports-related concussion. Comparisons between male and female athletes were explored using Mann-Whitney tests and chi-squared (χ2) tests as appropriate. Results We found that 60% of the participants stated that they have played in practice or during a game (this season) with concussion symptoms. Males expressed more negative outcomes of concussion reporting and lower concussion reporting intention, compared to females. We found no significant gender differences in concussion-reporting behaviours. Conclusion Our findings suggest that knowledge, favourable attitudes towards reporting and reporting intention alone are not enough to create an environment that encourages the disclosure of concussion symptoms. Health promotion communication campaigns, coupled with concussion education and awareness programmes, should be utilised to further highlight the importance of timely concussion management, and to create a culture in which the reporting of concussion is considered normative.
Gas Discharge Tube's Electromagnetic Pulse Response Prediction Based on Elman Neural Network

Electronic equipments may be disturbed by electromagnetic pulse during operation in some fields. Gas discharge tube is usually added as surge protection device to protect electronic equipment from electromagnetic pulse. Electromagnetic pulse current injection experiment is used to test gas discharge tube's protective characteristics. In order to reduce experimental times and guide experimental process, Elman neural network was used to predict electromagnetic pulse responses of gas discharge tube. Elman neural network is a recurrent neural network with local memory units and local feedback connections. Experiments showed that the Elman neural network model on gas discharge tube at different grades of voltage injection experiments have had better prediction results.
Alteration of Flt3-Ligand-dependent de novo generation of conventional dendritic cells during influenza infection contributes to respiratory bacterial superinfection

Secondary bacterial infections contribute to the excess morbidity and mortality of influenza A virus (IAV) infection. Disruption of lung integrity and impaired antibacterial immunity during IAV infection participate in colonization and dissemination of the bacteria out of the lungs. One key feature of IAV infection is the profound alteration of lung myeloid cells, characterized by the recruitment of deleterious inflammatory monocytes. We herein report that IAV infection causes a transient decrease of lung conventional dendritic cells (cDCs) (both cDC1 and cDC2) peaking at day 7 post-infection. While triggering emergency monopoiesis, IAV transiently altered the differentiation of cDCs in the bone marrow, the cDC1-biaised pre-DCs being particularly affected. The impaired cDC differentiation during IAV infection was independent of type I interferons (IFNs), IFN-γ, TNFα and IL-6 and was not due to an intrinsic dysfunction of cDC precursors. The alteration of cDC differentiation was associated with a drop of local and systemic production of Fms-like tyrosine kinase 3 ligand (Flt3-L), a critical cDC differentiation factor. Overexpression of Flt3-L during IAV infection boosted the cDC progenitors’ production in the BM, replenished cDCs in the lungs, decreased inflammatory monocytes’ infiltration and lowered lung damages. This was associated with partial protection against secondary pneumococcal infection, as reflected by reduced bacterial dissemination and prolonged survival. These findings highlight the impact of distal viral infection on cDC genesis in the BM and suggest that Flt3-L may have potential applications in the control of secondary infections.
Wender Utah Rating Scale-25 (WURS-25): psychometric properties and diagnostic accuracy of the Swedish translation

Abstract Objective: The aim of this study was to examine the psychometric properties and diagnostic accuracy of the Swedish version of the Wender Utah Rating Scale (WURS) in psychiatric patients with similar symptoms but diagnosed with either attention deficit hyperactivity disorder (ADHD), bipolar disorder (BP), and/or borderline personality disorder (BPD). Methods: A total of 121 patients from an outpatient psychiatric clinic for young adults (18–25 years) were diagnosed using the Structured Clinical Interview for DSM Axis I and Axis II (SCID-I and SCID-II), and ADHD was diagnosed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children (K-SADS). WURS were filled in by the participants and compared with a diagnosis of ADHD according to K-SADS. Results: Internal consistency of the WURS was 0.94. The principal component analysis resulted in a three-factor solution that accounted for 61.3% of the variance. The ADHD group had significantly higher mean scores compared to all other groups. The diagnostic accuracy of the WURS was examined using AUC and ROC analysis, and the optimal cut-off score was 39, with a sensitivity of 0.88 and specificity of 0.70, with AUC 0.87, 95% CI 0.80–0.94, PPV 0.59, and NPV 0.92. Conclusion: The psychometric properties of the Swedish WURS were good. For assessment of adult ADHD, in patients with symptoms of emotional instability, impulsivity, and attention problems but of different origins, a somewhat higher cut-off score than the originally suggested was preferable for identification of ADHD.
A Cloud-based Control System Architecture for Multi-UAV

Unmanned aerial vehicle is considered one of the most promising technologies. Controlling UAV over the cloud is an emerging research area motivated by the emergence of Cloud Robotics and the Internet-of-Things (IoT). This paper presents a control system architecture based on cloud platform which has been developed in order to allow multiple users to control and monitor multiple UAVs simultaneously irrespective of the location. Furthermore, the system allows to build and allocate missions to UAV and analyze the execution data that collect by sensors. The architecture of the system is fully based on open source software and protocols. To demonstrate the effectiveness of the system architecture, we implemented and validated it using SITL (software in the loop) simulator. Experimental results show that the system is efficient in monitoring and controlling UAV remotely through the Internet.
Sildenafil in the Treatment of Erectile Dysfunction in Parkinson's Disease

Erectile dysfunction (ED) is a common nonmotor feature in patients with Parkinson's disease (PD). Data regarding the tolerability and efficacy of anti‐ED medication in the PD population are limited. The aim of this work was to assess the safety and efficacy of sildenafil in treatment of ED in men with PD.
Towards static recovery of micro state transitions from legacy embedded code

During the development of an embedded system, state transition models are frequently used for modeling at several abstraction levels. Unfortunately, specification documents including such model are often lost or not up to date during maintenance/reuse. Based on our experience in industrial collaboration, we present Micro State Transition Table (MSTT) to help developers understanding embedded code based on a fine-grained state transition model. We also discuss the challenges of static recovery of an MSTT.
Prognostic Factors in Adult Patients with Dengue: Developing Risk Scoring Models and Emphasizing Factors Associated with Death ≤7 Days after Illness Onset and ≤3 Days after Presentation

Dengue is a mosquito-borne viral disease that is a threat to global health. However, information relating to mortality ≤7 days after dengue onset and ≤3 days after presentation is limited. We retrospectively analyzed 1086 adults with dengue during a 12-year period. Three scoring models were established: model-1 (death ≤3 days after presentation), model-2 (death ≤7 days after illness onset), and model-3 (overall fatality). In total, 39 patients with fatal dengue were identified, of which 17 and 14 patients died ≤7 days after illness onset and ≤3 days after presentation, respectively. In model-1 (range: 0‒4 points), gastrointestinal bleeding ≤72 h after presentation, thrombocytopenia (<50 × 109 cells/L) at presentation, and acute kidney injury after hospitalization, using a cutoff level of 2 points, exhibited good discrimination (area under the receiver curve (AUC): 0.975) between survivors and non-survivors. In model-2, the significant predictors were gastrointestinal bleeding ≤72 h after presentation, and hemoconcentration and leukocytosis after hospitalization. Model-2 (range: 0–4 points) showed an AUC of 0.974, with a cutoff value of 2 points. The independent factors in model-2 were the predictors of overall mortality (model-3), which include thrombocytopenia (<50 × 109 cells/L) at presentation. Using a cutoff value of 2 points, model-3 (range: 0–7 points) revealed an excellent discrimination between survivors and non-survivors (AUC: 0.963).
Scaling Speech Enhancement in Unseen Environments with Noise Embeddings

We address the problem of speech enhancement generalisation to unseen environments by performing two manipulations. First, we embed an additional recording from the environment alone, and use this embedding to alter activations in the main enhancement subnetwork. Second, we scale the number of noise environments present at training time to 16,784 different environments. Experiment results show that both manipulations reduce word error rates of a pretrained speech recognition system and improve enhancement quality according to a number of performance measures. Specifically, our best model reduces the word error rate from 34.04% on noisy speech to 15.46% on the enhanced speech. Enhanced audio samples can be found in https://speechenhancement.page. link/samples.
Early Clinical Predictors of Treatment‐Resistant and Functional Outcomes in Parkinson's Disease

The aim of this work was to identify early clinical predictors of important outcomes in Parkinson's disease (PD). In PD, treatment‐resistant (e.g., dementia, falling) and other important functional outcomes (e.g., declines in quality of life [QOL] and activities of daily living [ADL]) emerge and become increasingly disabling.
Comparison of Corticosteroid and Vincristine in Treating Kaposiform Hemangioendothelioma and Tufted Angioma: A Systematic Review and Meta-Analysis

Abstract Objective To evaluate the outcome and safety of corticosteroids and vincristine (VCR) in the treatment of kaposiform hemangioendothelioma (KHE) and tufted angioma (TA). Materials and Methods Clinical studies involving corticosteroids and VCR therapies in treating KHE/TA were identified by using PubMed, Cochrane Library, OVID, EBSCO, CNKI, VIP, and Wanfang databases from their establishment date to December 2017. Randomized controlled trials, case–control, or case series with more than five cases were included. The following data were extracted: study sample, demographics, responses rate, recurrence rate, and adverse reactions. Two reviewers completed screening and extraction. Methodological quality was evaluated with quality appraisal tool. Results A total of 266 studies were found, and 27 studies were finally included in this research; quality of all studies was low. Seven studies with a total of 123 participants, which compared the effect of systemic corticosteroids with that of VCR, were performed for the meta-analysis. The results indicated that the effect of VCR was significantly higher than that of corticosteroids (relative risk [RR] = 2.08, 95% confidence interval [CI]: 1.38–3.16). The recurrence rate of VCR (11.1%) was lower than that of corticosteroids (50%), but there was no statistical difference between the two therapies (p = 0.1312). The result of pooled adverse reactions response rate for VCR was 18.2%, significantly lower than that for corticosteroids, which was 52.0%. Conclusion The present profile shows that VCR is relatively more effective and safer in treating KHE/TA than corticosteroids are. So, we believe VCR could be used as a first-line medication agent in the treatment of KHE/TA.
Discovery of peptide ligands targeting a specific ubiquitin-like domain–binding site in the deubiquitinase USP11

Ubiquitin-specific proteases (USPs) reverse ubiquitination and regulate virtually all cellular processes. Defined noncatalytic domains in USP4 and USP15 are known to interact with E3 ligases and substrate recruitment factors. No such interactions have been reported for these domains in the paralog USP11, a key regulator of DNA double-strand break repair by homologous recombination. We hypothesized that USP11 domains adjacent to its protease domain harbor unique peptide-binding sites. Here, using a next-generation phage display (NGPD) strategy, combining phage display library screening with next-generation sequencing, we discovered unique USP11-interacting peptide motifs. Isothermal titration calorimetry disclosed that the highest affinity peptides (KD of ∼10 μm) exhibit exclusive selectivity for USP11 over USP4 and USP15 in vitro. Furthermore, a crystal structure of a USP11–peptide complex revealed a previously unknown binding site in USP11's noncatalytic ubiquitin-like (UBL) region. This site interacted with a helical motif and is absent in USP4 and USP15. Reporter assays using USP11-WT versus a binding pocket–deficient double mutant disclosed that this binding site modulates USP11's function in homologous recombination–mediated DNA repair. The highest affinity USP11 peptide binder fused to a cellular delivery sequence induced significant nuclear localization and cell cycle arrest in S phase, affecting the viability of different mammalian cell lines. The USP11 peptide ligands and the paralog-specific functional site in USP11 identified here provide a framework for the development of new biochemical tools and therapeutic agents. We propose that an NGPD-based strategy for identifying interacting peptides may be applied also to other cellular targets.
The impact of variations in input directions according to ISO 14243 on wearing of knee prostheses

ISO 14243 is the governing standard for wear testing of knee prostheses, but there is controversy over the correct direction of anterior-posterior (AP) displacement and loading and the correct direction of tibial rotation (TR) angles and torque. This study aimed to analyze how altering the direction of AP and TR affected wear on the tibial insert. Modifications to the conditions specified in ISO 14243–1 and ISO 14243–3 were also proposed. As such, five loading conditions were applied to FEA models of a knee prosthesis: (1) Modified ISO 14243–3 with positive AP displacement and TR angle, (2) ISO 14243–3:2004 with negative AP displacement and positive TR angle, (3) ISO 14243–3:2014 with positive AP displacement and negative TR angle, (4) Modified ISO 14243–1 with positive AP load and TR torque, and (5) ISO 14243–1:2009 with negative AP load and positive TR torque. This study found that changing the input directions for AP and TR according to ISO 14243–1 and 14243–3 had an influence on the wear rate and wear contours on the tibial insert model. However, the extent of wear varies depending on the design features of the tibial insert and shape of the input curves. For displacement control according to ISO 14243–3, changing the direction of AP displacement had a marked influence on the wear rate (272.77%), but changing the direction of TR angle had a much lower impact (2.17%). For load control according to ISO 14243–1, reversing the AP load (ISO 14243–1:2009) only increased the wear rate by 6.73% in comparison to the modified ISO 14243–1 conditions. The clinical relevance of this study is that the results demonstrate that tibial wear is affected by the direction of application of AP and TR. Incorrect application of the loading conditions during the design stage may lead to an ineffective preclinical evaluation and could subsequently influence implant longevity in clinical use.
Sentiment analysis in organizational work: Towards an ontology of people analytics

The present paper proposes a conceptual ontology to evaluate human factors by modelling their key performance indicators and defining these indicators' explanatory factors, manifestations, and diverse corresponding digital footprints. Our methodology incorporates 6 main human resource constructs: performance, engagement, leadership, workplace dynamics, organizational developmental support, and learning and knowledge creation. Using sentiment analysis, we introduce a potential way to evaluate several components of the proposed human factors ontology. We use the Enron email corpus as a test case, to demonstrate how digital footprints can predict such phenomena. In so doing, we hope to encourage further research applying data mining techniques to allow real‐time, less costly, and more reliable assessments of human factor patterns and trends.
Regret vs. Bandwidth Trade-off for Recommendation Systems

We consider recommendation systems that need to operate under wireless bandwidth constraints, measured as number of broadcast transmissions, and demonstrate a (tight for some instances) tradeoff between regret and bandwidth for two scenarios: the case of multi-armed bandit with context, and the case where there is a latent structure in the message space that we can exploit to reduce the learning phase.