Miracle-dz/UniFAR-FTUs huggingface dataset:
Essential Oil Delivery Route: Effect on Broiler Chicken’s Growth Performance, Blood Biochemistry, Intestinal Morphology, Immune, and Antioxidant Status

Simple Summary Much research is devoted to the search for potent alternatives to antibiotic growth promoters in the poultry industry. It is hypothesized that the efficacy of potential alternatives could be influenced by their type and the delivery strategy utilized. Consequently, this study evaluated the efficacy of a commercial essential oil blend across different delivery routes as a potent alternative to in-feed antibiotics in broiler chickens using selected biochemical, immune, and performance parameters. The results provide evidence that the successive delivery of essential oils via in ovo and in-water routes in broiler chickens offers the potential to improve broiler chicken biochemical and antioxidant status. However, the in ovo delivery of essential oil at 0.2 mL dosage (saline + essential oil, dilution ratio—2:1) suffers the limitations of reduced hatchability. Abstract This study evaluated the effect of an essential oil blend and its delivery routes on broiler chicken growth performance, blood biochemistry, intestinal morphology, and immune and antioxidant status. Eggs were incubated and allotted to 3 groups: non-injected group, in ovo saline group, and in ovo essential oil group. On day 18 of incubation, essential oil in saline or saline alone was injected into the amnion. At hatch, chicks were assigned to post-hatch treatment combinations (1) in ovo essential oil + in-water essential oil (in ovo + in-water EO); (2) in ovo essential oil (in ovo EO); (3) in ovo saline; (4) in-water essential oil; (5) in-feed antibiotics (Bacitracin methylene disalicylate) and (6) a negative control (NC; corn-wheat-soybean diet) in 8 replicate cages (6 birds/cage) and raised for 28 day. The in ovo EO group reduced (p < 0.05) chick length and hatchability, all groups recorded no difference in growth performance at 0–28 day. The in ovo + in-water EO treatment reduced (p < 0.05) blood creatine kinase and aspartate aminotransferase levels whilst increasing (p < 0.05) total antioxidant capacity in birds. The in ovo + in-water delivery of EO might represent a potential antibiotic reduction strategy for the poultry industry but more research is needed to address the concern of reduced hatchability.
Investigation of a resonance microgenerator

Microgenerators that could extract energy from the environment would be very attractive for powering some types of microsystems. One approach uses a mechanical resonant element to transfer seismic vibrations into useful motion. A novel configuration for an electromagnetic microgenerator and an electrostatic microgenerator has been modelled and confirmed by experiments at a small macroscopic scale. This design allows the possibility of a 'stacked' array to increase the output. However it is concluded, as with other studies, that few applications are plausible with the outputs that can be achieved. A power output of 6 nW is predicted for a typical single-element electromagnetic microgenerator but at a very low voltage. The electrostatic form delivers more useful voltage but, at the small scale, its reactive impedance is much too high for useful power delivery.
Natural Compounds as Target Biomolecules in Cellular Adhesion and Migration: From Biomolecular Stimulation to Label-Free Discovery and Bioactivity-Based Isolation

Plants and fungi can be used for medical applications because of their accumulation of special bioactive metabolites. These substances might be beneficial to human health, exerting also anti-inflammatory and anticancer (antiproliferative) effects. We propose that they are mediated by influencing cellular adhesion and migration via various signaling pathways and by directly inactivating key cell adhesion surface receptor sites. The evidence for this proposition is reviewed (by summarizing the natural metabolites and their effects influencing cellular adhesion and migration), along with the classical measuring techniques used to gain such evidence. We systematize existing knowledge concerning the mechanisms of how natural metabolites affect adhesion and movement, and their role in gene expression as well. We conclude by highlighting the possibilities to screen natural compounds faster and more easily by applying new label-free methods, which also enable a far greater degree of quantification than the conventional methods used hitherto. We have systematically classified recent studies regarding the effects of natural compounds on cellular adhesion and movement, characterizing the active substances according to their organismal origin (plants, animals or fungi). Finally, we also summarize the results of recent studies and experiments on SARS-CoV-2 treatments by natural extracts affecting mainly the adhesion and entry of the virus.
Tunable single-mode fiber reflective grating filter

A single-mode fiber tunable reflective filter is demonstrated by translating a fan-shaped grating structure through the evanescent field of a side-polished fiber. Filter linewidths of about 1 nm were measured over tuning ranges in excess of 65 nm. Reflectivities as high as 88 percent were observed. Using the fiber filter as a feedback element, a multimode semiconductor laser was observed to oscillate in a single mode which could be discretely turned over a wavelength range of 26 nm.
A Preliminary Numerical Investigation of Thermal Mixing Efficiency in T-Junctions with Different Flow Configurations

When hot and cold fluids flow through a converging T-junction, rapid temperature fluctuations occur in the mixing region due to the thermal mixing of fluids. This temperature fluctuation causes thermal fatigue, which is responsible for the shortening of service life in a T-junction. Hence, the design of T-junction for thermal mixing requires not only superior mixing performance but minimize thermal fluctuation during mixing is also desirable. The objective of the present paper is to determine the thermal mixing performance at the mixing region of T-junction with two different flow configurations. Water, at different inlet temperatures, is used as a working medium and is assumed incompressible. Two types of flow configurations, namely intersecting and colliding regular T-junction with a sidearm pointing at 12 o’clock position have been evaluated in this paper. Realizable k-epsilon turbulence model was assumed, and its validity benchmarked against RANS and RSM-EB turbulence models. The thermal mixing efficiency of both flow configurations is calculated and compared. The results show that the thermal mixing efficiency of both intersecting and colliding mixing tee increases with the increase of distance and time. Intersecting tee shows higher temperature fluctuation than colliding tee at the mixing outlet, but colliding tee shows higher thermal mixing efficiency than intersecting mixing tee.
Mixed Reality-Enhanced Intuitive Teleoperation with Hybrid Virtual Fixtures for Intelligent Robotic Welding

This paper presents an integrated scheme based on a mixed reality (MR) and haptic feedback approach for intuitive and immersive teleoperation of robotic welding systems. By incorporating MR technology, the user is fully immersed in a virtual operating space augmented by real-time visual feedback from the robot working space. The proposed robotic tele-welding system features imitative motion mapping from the user’s hand movements to the welding robot motions, and it enables the spatial velocity-based control of the robot tool center point (TCP). The proposed mixed reality virtual fixture (MRVF) integration approach implements hybrid haptic constraints to guide the operator’s hand movements following the conical guidance to effectively align the welding torch for welding and constrain the welding operation within a collision-free area. Onsite welding and tele-welding experiments identify the operational differences between professional and unskilled welders and demonstrate the effectiveness of the proposed MRVF tele-welding framework for novice welders. The MRVF-integrated visual/haptic tele-welding scheme reduced the torch alignment times by 56% and 60% compared to the MRnoVF and baseline cases, with minimized cognitive workload and optimal usability. The MRVF scheme effectively stabilized welders’ hand movements and eliminated undesirable collisions while generating smooth welds.
Toward Improved Understanding and Management of Software Clones

The cloning of code is controversial as a development practice. Empirical studies on the long-term effects of cloning on software quality and maintainability have produced mixed results. Some studies have found that cloning has a negative impact on code readability, bug propagation, and the presence of cloning may indicate wider problems in software design and management. At the same time, other studies have found that cloned code is less likely to have defects, and thus is arguably more stable, better designed, and better maintained. These results suggest that the effect of cloning on software quality and maintainability may be determinable only on a case-by-case basis, and this only aggravates the challenge of establishing a principled framework of clone management and understanding. This thesis aims to improve the understanding and management of clones within software systems. There are two main contributions. First, we have conducted an empirical study on cloning in one of the major device drivers families of the Linux kernel. Different from many previous empirical studies on cloning, we incorporate the knowledge about the development style, and the architecture of the subject system into our study; our findings address the evolution of clones; we have also found that the presence of cloning is a strong predictor (87% accuracy) of one aspect of underlying hardware similarity when compared to a vendor-based model (55% accuracy) and a randomly chosen model (9% accuracy). The effectiveness of using the presence of cloning to infer high-level similarity suggests a new perspective of using cloning information to assist program comprehension, aspect mining, and software product-line engineering. Second, we have devised a triage-oriented taxonomy of clones to aid developers in prioritizing which kinds of clones are most likely to be problematic and require attention; a preliminary validation of the utility of this taxonomy has been performed against a large open source system. The cloning-based software quality assurance (QA) framework based on our taxonomy adds a new dimension to traditional software QA processes; by exploiting the clone detection results within a guided framework, the developer is able to evaluate which instances of cloning are most likely to require urgent attention.
Temperature data transmission by multifrequency SWFM signal using an optical fiber

This paper describes the optical transmission of multifrequency FM signals on a pair of channels. Each channel-consists of 4 bits, which correspond to multifrequencies at 210 kHz, 520 kHz, 715 kHz, and 1.02 MHz. In the sender, a pair of analog temperature data are converted into 4 bits of digital data on a pair of channels. Each bit of digital data is assigned to a frequency signal, and each multifrequency signal consisting of mixed frequency signals of 4 bits is fed to the respective FM modulator. An FM signal is mixed with another FM signal, and the mixed FM signals are fed to the VCO operating as the SWFM modulator at 20 MHz. The VCO output is fed to the electrical-to-optical (E/O) converter, and then sent to the GI optical fiber. The GI optical fiber is used to send digitized temperature data at low speed over a distance of 1 km. Data was satisfactorily transferred between the sender and the receiver.
Diagnostic Accuracy of Confocal Laser Endomicroscopy for the Diagnosis of Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

Background: Advances in treatment approaches for patients with oral squamous cell carcinoma (OSCC) have been unsuccessful in preventing frequent recurrences and distant metastases, leading to a poor prognosis. Early detection and prevention enable an improved 5-year survival and better prognosis. Confocal Laser Endomicroscopy (CLE) is a non-invasive imaging instrument that could enable an earlier diagnosis and possibly help in reducing unnecessary invasive surgical procedures. Objective: To present an up to date systematic review and meta-analysis assessing the diagnostic accuracy of CLE in diagnosing OSCC. Materials and Methods. PubMed, Scopus, and Web of Science databases were explored up to 30 June 2021, to collect articles concerning the diagnosis of OSCC through CLE. Screening: data extraction and appraisal was done by two reviewers. The quality of the methodology followed by the studies included in this review was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool. A random effects model was used for the meta-analysis. Results: Six studies were included, leading to a total number of 361 lesions in 213 patients. The pooled sensitivity and specificity were 95% (95% CI, 92–97%; I2 = 77.5%) and 93% (95% CI, 90–95%; I2 = 68.6%); the pooled positive likelihood ratios and negative likelihood ratios were 10.85 (95% CI, 5.4–21.7; I2 = 55.9%) and 0.08 (95% CI, 0.03–0.2; I2 = 83.5%); and the pooled diagnostic odds ratio was 174.45 (95% CI, 34.51–881.69; I2 = 73.6%). Although risk of bias and heterogeneity is observed, this study validates that CLE may have a noteworthy clinical influence on the diagnosis of OSCC, through its high sensitivity and specificity. Conclusions: This review indicates an exceptionally high sensitivity and specificity of CLE for diagnosing OSCC. Whilst it is a promising diagnostic instrument, the limited number of existing studies and potential risk of bias of included studies does not allow us to draw firm conclusions. A conclusive inference can be drawn when more studies, possibly with homogeneous methodological approach, are performed.
THE UNWINDING OF A PROTOCOL

The concepts supporting Radio Frequency Identification (RFID) have been around for about 70 years. However, today the commercial implementation of RFID is a very popular subject in many areas of business and technology. There are two types of tags, active with an on board power source, and passive with no on board power source. The current popularity results from the ability to fabricate ultra-low power, inexpensive CMOS silicon chips that make it practical. The RFID tags contain an antenna attached to a chip on a flexible substrate and use a communications protocol to respond to an interrogator (reader). All of the power to operate the chip on a passive tag is derived from a continuous wave (CW) supplied by the reader along with the commands or primitives from the reader to the tag. The tag responses to the reader are likewise communication primitives. The notable EPCglobal Class 1 Gen 2 protocol from EPCglobal is being standardized as an ISO protocol under ISO18000 — Part 6C. Due to the power being derived from the reader, it is important to reduce the requirement of the CMOS chip to a minimum. Decreased power translates into increased rage or possibly more robustness with respect to the relative reader/tag antenna polarization and orientation. In the sense of computer architecture, the Part 6C protocol is analogous to a CISC processor when compared to the ISO18000 — Part 7 active (battery powered) RFID standard which is more like a RISC processor. The more complicated the primitives (instructions), the more power required on the chip to interrogate commands and to save intermediate states. This article addresses the issues of analyzing the Part 6C (EPC) protocol in the hope that a simpler set of primitives would reduce the on-chip power consumption thereby providing an advantage possibly for distance or robustness while transferring much of the communication workload to the reader.
A Practical Approach to IP Live Production

Serial digital interface (SDI) infrastructure has been a fundamental building block for video and audio communications within studios for many years. Meanwhile, the bandwidth of generic Internet Protocol (IP) networks has continued to increase along with falling costs, such that 10 Gbit/sec infrastructure is now commonly available. Exploiting this high-bandwidth commodity infrastructure, an IP network could be deployed in the studio to form an IP live production system. This paper explores the technical requirements, design considerations, and standards approaches for IP live production to be able to deliver business benefits compared to current SDI technology whilst retaining familiar SDI-based production practices. This paper also describes a sample implementation of an IP-based audio-video router showing how the discussed technologies can be applied to realize the same functionality as a conventional SDI router.
Global Studies of the Host-Parasite Relationships between Ectoparasitic Mites of the Family Syringophilidae and Birds of the Order Columbiformes

Simple Summary Mites of the family Syringophilidae (Acariformes: Cheyletoidea)—also called quill mites—are permanent and highly specialized ectoparasites of birds living inside the calamus of the various types of the feathers. In the present paper, we conducted a study focused on prevalence, host specificity, networks, and phylogeny of the syringophilid mites parasitizing on pigeon and doves (Columbiformes). We postulate that the Syringophilidae mites and Columbiformes bird system represent a model which can be used in a broader study of the relationship between hosts and parasites. Abstract The quill mites belonging to the family Syringophilidae (Acari: Prostigmata: Cheyletoidea) are obligate ectoparasites of birds. They inhabit different types of the quills, where they spend their whole life cycle. In this paper, we conducted a global study of syringophilid mites associated with columbiform birds. We examined 772 pigeon and dove individuals belonging to 112 species (35% world fauna) from all zoogeographical regions (except Madagascan) where Columbiformes occur. We measured the prevalence (IP) and the confidence interval (CI) for all infested host species. IP ranges between 4.2 and 66.7 (CI 0.2–100). We applied a bipartite analysis to determine host–parasite interaction, network indices, and host specificity on species and whole network levels. The Syringophilidae–Columbiformes network was composed of 25 mite species and 65 host species. The bipartite network was characterized by a high network level specialization H2′ = 0.93, high nestedness N = 0.908, connectance C = 0.90, and high modularity Q = 0.83, with 20 modules. Moreover, we reconstructed the phylogeny of the quill mites associated with columbiform birds on the generic level. Analysis shows two distinct clades: Meitingsunes + Psittaciphilus, and Peristerophila + Terratosyringophilus.
The Imbalance of Mitochondrial Fusion/Fission Drives High-Glucose-Induced Vascular Injury

Emerging evidence shows that mitochondria fusion/fission imbalance is related to the occurrence of hyperglycemia-induced vascular injury. To study the temporal dynamics of mitochondrial fusion and fission, we observed the alteration of mitochondrial fusion/fission proteins in a set of different high-glucose exposure durations, especially in the early stage of hyperglycemia. The in vitro results show that persistent cellular apoptosis and endothelial dysfunction can be induced rapidly within 12 hours’ high-glucose pre-incubation. Our results show that mitochondria maintain normal morphology and function within 4 hours’ high-glucose pre-incubation; with the extended high-glucose exposure, there is a transition to progressive fragmentation; once severe mitochondria fusion/fission imbalance occurs, persistent cellular apoptosis will develop. In vitro and in vivo results consistently suggest that mitochondrial fusion/fission homeostasis alterations trigger high-glucose-induced vascular injury. As the guardian of mitochondria, AMPK is suppressed in response to hyperglycemia, resulting in imbalanced mitochondrial fusion/fission, which can be reversed by AMPK stimulation. Our results suggest that mitochondrial fusion/fission’s staged homeostasis may be a predictive factor of diabetic cardiovascular complications.
Adaptive Tracking Method of Distorted Voltage Using IMM Algorithm under Grid Frequency Fluctuation Conditions

This paper newly proposes an interactive multiple model (IMM) algorithm to adaptively track distorted AC voltage with the grid frequency fluctuation. The usual tracking methods are Kalman filter (KF) algorithm with a fixed frequency and KF algorithm with frequency identifier. The KF algorithm with a fixed frequency has a larger covariance parameter to guarantee the tracking robustness. However, it has a large tracking error. The KF algorithm with frequency identifier overly depends on the accuracy and stability of frequency identifier. The advantage of the proposed method is that it is decoupled from frequency detection and does not depend on frequency detection accuracy. First, the orthogonal vector dynamic (OVD) tracking model of the sine wave is established. Then, a model set covering the grid frequency fluctuation range is formed, and a new OVD-IMM tracking algorithm is proposed in combination with IMM algorithm. In the end, the effectiveness and accuracy of the proposed OVD-IMM algorithm are verified through simulations and experiments.
Six Sigma implementation in Ireland: the role of multinational firms

Purpose – The purpose of this study is to examine the intra‐organisational diffusion of management innovations, taking Six Sigma as an example.Design/methodology/approach – The study focuses on Six Sigma implementation among companies operating in Ireland. It makes use of a theoretical framework, which posits that multinational firms act as a diffusion mechanism for Six Sigma. The analysis of Six Sigma implementation consists of an online survey to which 132 firms responded. Subsequently, a qualitative analysis of Six Sigma implementation was conducted through semi‐structured interviews with 13 respondents.Findings – The results show that roughly half of respondent firms use Six Sigma. These firms are typically large US multinationals, which have used Six Sigma for at least three years. Intra‐organisational diffusion does exist. Multinationals do act as a diffusion mechanism – with the adoption of Six Sigma at US headquarters level and then the diffusion of the practice internally to the Irish subsidiary .
Adaptive differential detection for M-ary DPSK

The adaptive differential detection (adaptive DD) of M-ary DPSK signals is proposed in which the phase reference for differential detection is estimated using the least mean square algorithm with step size optimally adapted to changing channel conditions. The Viterbi algorithm and decision feedback algorithm are applied to effectively perform the maximum likelihood detection of the transmitted phase sequence. The bit error rate (BER) performance of adaptive DD is evaluated by computer simulations of 4DPSK in additive Gaussian noise (AWGN) and Rayleigh fading channels. In AWGN channels, BER performance close to that of coherent detection with differential decoding is achieved with a performance loss of only 0.3 dB. In Rayleigh fading, the irreducible BER owing to fading Doppler spread can be reduced almost by half compared with conventional DD without prior knowledge of fading statistics.