Miracle-dz/UniFAR-FTUs huggingface dataset:
Polarized Transport of Alzheimer Amyloid Precursor Protein Is Mediated by Adaptor Protein Complex AP1‐1B

Alzheimer amyloid precursor protein (APP) is the precursor for the Aβ peptide involved in pathogenesis of Alzheimer's disease. The soluble ectodomain fragment of APP (sAPP) functions as a growth factor for epithelial cells, suggesting an important function for APP outside neuronal tissue. Previous studies have shown that in polarized epithelial cells, APP is targeted to the basolateral domain. Tyr653 within the cytoplasmic tail of APP mediates the basolateral targeting of APP, but the sorting machinery that binds to this residue has largely remained unknown. In this study, we analyzed the role of adaptor complexes in the polarized sorting of APP. We show that the medium subunit μ1B of the epithelia‐specific adaptor protein (AP)‐1B binds onto the cytoplasmic tail of APP in a Tyr653‐dependent way. Moreover, ectopic expression of μ1B in cells lacking AP‐1B resulted in correction of apical missorting of wild‐type but not Tyr653Ala APP. Basolateral secretion of sAPP was found to be independent of Tyr653. We propose a model for polarized targeting of APP according to which sorting of APP to basolateral domain is dependent on binding of AP‐1B on Tyr653 in basolateral endosomes. This model is in accordance with the current understanding of sorting mechanisms mediating polarized targeting of membrane proteins.
Optical under-sampling for high resolution analog-to-digital conversion

A self-coherent optically-sampled analog-to-digital converter (ADC) using an I/Q optical hybrid coupler is experimentally demonstrated. It leverages practical, commercially available components and is used for high-resolution under-sampling with up to 20GHz carrier frequencies. The ADC resolution is 8.7 effective bits for a 10GHz carrier frequency.
The Applicability Of Internal Marketing Factors To Boost Internal Service Quality

Nowadays, the concept of internal marketing has been applied well to only certain company. More than 30 years ago, internal marketing have been proposed as the first solution to solve the problem in delivering high Internal Service Quality (ISQ). The purpose of this research is to examine the applicability of Internal marketing (IM) factors in relation to the Internal Service Quality (ISQ) of the company. In this study, Pos Malaysia Berhad Company is selected among the company in Malaysia to investigate how the Internal Marketing element and the anticipated Internal Service Quality relate in the company. The research applies six internal marketing practices in terms of employee motivation, effective communication, employee selection, employment development, support system and healthy work environment; and the delivered internal service quality. A series of interview is conducted to collect the 103 respondents answers, while the data collected is analyzed quantitatively by using the Factor Analysis and Multiple Regression Analysis. The results indicate that there is a positive relation between the elements of the Internal Market and the anticipated Internal Service Quality in variable magnitude. In addition to that, the research shows that the support system has effected the changes in Internal Service Quality the most. Service providers are advised to apply the Internal Marketing to foster a better external service quality because in order to satisfy the customer, the company has to satisfy the employee first.
Transcriptomic-based bioassays for the detection of type A trichothecenes

The type A trichothecenes T-2 toxin (T-2) and HT-2 toxin (HT-2) are hazardous Fusarium products that contaminate many field crops growing in cold to temperate regions across the world. Toxicity studies in laboratory and farm animals have been used to derive a temporary tolerable daily intake (t-TDI) for the sum of T-2 and HT-2 of no more than 60 ng/kg body weight. To protect the consumers, it is now necessary to screen a large number of food samples for the presence of these poisonous fungal metabolites. Towards that goal, we discovered that the transcriptional apparatus of a human carcinoma cell line (MCF7) provides a sensitive biological sensor of type A trichothecenes. In fact, exposure of this easy-to-culture cell line to T-2 or HT-2 results in the regulation of >2,000 different transcripts with expression changes ranging from >5,000-fold gene inductions to >40-fold gene repressions. These transcriptional responses have been exploited to develop practical microchip and reverse transcription-polymerase.
Hybrid approach for tuberculosis data classification using optimal centroid selection based clustering

Application of classification technique in healthcare is challenging because of high dimensional medical data and of its dynamic nature. The research work here is focused on the study of various approaches for transformation large data into smaller datasets in effective manner so that accurate classification could be performed. Data clustering is a machine learning approach which divides dataset into smaller partitions and having higher intra partition similarity within it and dissimilarity among different partitions. Many clustering algorithm exists for varying nature of dataset and own their advantages as well as limitations as per nature of individual datasets thus there is sufficient scope to explore efficient and new algorithm for clustering based classification. This paper presents a new approach for centroid selection in k-mean algorithm for health datasets which gives better clustering results in comparison to traditional k-mean algorithm. The algorithm is evaluated against tuberculosis dataset and then results are applied to classifier for performance evaluation and results show improvement over previous algorithm.
Analysis of camera's images influenced by light variation

Cameras are excellent sensors for robots in unstructured environment such as human living space. However, a camera being extreme sensitive to light illumination variation restricts robots in human life. In this paper, color image of a camera influenced by light variation is studied for practical applications used as robot sensors in future. Firstly, the influence of camera's image data due to varying light illumination is analyzed to build a database consisted of the sets of threshold values. In the analysis, the change rules of the YUV components due to varying illumination is induced for color segmentation of robots against unstable lighting.
Multisector Eigenbeamforming With MMSE Reception in Spatially Correlated Channels

Single-sector eigenbeamforming is effective for obtaining transmit array gain in spatially correlated fading channels while reducing the feedback signaling overhead. However, it may suffer from interference near the sector boundary when applied to the downlink with universal frequency reuse. This interference may not sufficiently be handled by a minimum mean square error (MMSE)-type receiver. To alleviate the interference problem, we consider the use of multisector eigenbeamforming (MEB) in an MMSE receiver, which requires cooperation between adjacent sectors in the same cell. We analyze the performance of the MEB with the use of long-term channel information in terms of the ergodic capacity. Finally, the effectiveness of the proposed MEB near the sector boundary is verified by computer simulation.
Mizspellin and Medline

Literature searches, whether conducted for patient care or for construction of a systematic overview, depend on at least two factors to be comprehensive. These are, firstly, use of an inclusive set of search strategies,1 and, secondly, correct entry and referencing of published material within the database.2 There is limited evidence on the accuracy of information within electronic databases. We assessed the accuracy of entries in Medline by searching for misspelt textwords. We conducted a literature search of 10 …
SIRT1 Negatively Regulates the Activities, Functions, and Protein Levels of hMOF and TIP60

ABSTRACT SIRT1 is a NAD+-dependent histone H4K16 deacetylase that controls several different normal physiologic and disease processes. Like most histone deacetylases, SIRT1 also deacetylates nonhistone proteins. Here, we show that two members of the MYST (MOZ, Ybf2/Sas3, Sas2, and TIP60) acetyltransferase family, hMOF and TIP60, are SIRT1 substrates. SIRT1 deacetylation of the enzymatic domains of hMOF and TIP60 inhibits their acetyltransferase activity and promotes ubiquitination-dependent degradation of these proteins. Importantly, immediately following DNA damage, the binding of SIRT1 to hMOF and TIP60 is transiently interrupted, with corresponding hMOF/TIP60 hyperacetylation. Lysine-to-arginine mutations in SIRT1-targeted lysines on hMOF and TIP60 repress DNA double-strand break repair and inhibit the ability of hMOF/TIP60 to induce apoptosis in response to DNA double-strand break. Together, these findings uncover novel pathways in which SIRT1 dynamically interacts with and regulates hMOF and TIP60 through deacetylation and provide additional mechanistic insights by which SIRT1 regulates DNA damage response.
APPLICATION OF PHASED ARRAY TECHNIQUES TO THE REACTOR INTERNAL PUMP CASING WELD

Integrity of the inconel weld joint connecting Reactor Internal Pump (RIP) casing to the Reactor Pressure Vessel (RPV) in Advanced Boiler Water Reactor (ABWR) is important for safety. The difficulty in examining is mainly caused by limited access space. The probes, scanner, and cabling has to be assembled within a high radiation dose rates working space of 18mm in height. In this research, a specific ultrasonic phased array probe and CIVA simulation were used to develop an efficient inspection technique. UT simulation on the RIP casing weld and mockup test result will be shown.
Organic conductors: from charge density wave TTF-TCNQ to superconducting (TMTSF)2PF6.

Superconductivity, that is, the possibility for electrons to flow through a conductor without any energy loss, has been the fuel for a very large number of industrial applications of physics in the twentieth century. Just to mention some of them which are important in current life, we have the power loss energy transfer, the production of very strong magnetic fields for medical imaging or for plasma confinement (the fusion problem) voltage standards, particle accelerators, and magnetic flux sensors.
Immunolocalization of PICK1 in the ascending auditory pathways of the adult rat

Protein that interacts with C‐kinase α (PICK1) is a PDZ domain protein that interacts with many binding partners in the central nervous system (CNS), including activated protein kinase Cα and subunits of the AMPA subtype of glutamate receptor. Almost nothing is known about the anatomic distribution of PICK1 in the intact adult CNS. By using PICK1 antisera and peroxidase immunocytochemistry, we report on the distribution of PICK1 in the ascending pathways of the central auditory system of the adult rat. PICK1‐immunoreactivity (ir) was observed in many component nuclei of the central auditory system, including the dorsal cochlear nucleus, anteroventral cochlear nucleus, posteroventral cochlear nucleus, some divisions of the superior olivary complex, inferior colliculus, medial geniculate body, and primary auditory cortex. The general staining pattern for PICK1‐immunoreactivity was somatodendritic with scattered puncta in neuropil and somatodendritic regions. The distribution of PICK1 partially overlaps with PKCα and glutamate receptor subunits such as GluR2. These data suggest that PICK1 may function in the regulation of PKCα and GluR2 localization in components of the rat auditory system, which may be a fundamental mechanism of synaptic transmission and/or plasticity. J. Comp. Neurol. 450:382–394, 2002. © 2002 Wiley‐Liss, Inc.
Localization of Transforming Growth Factor Beta Receptor II Interacting Protein-1 in Bone and Teeth

Transforming growth factor beta receptor II (TGFβR-II) interacting protein 1 (TRIP-1) is a WD-40 protein that binds to the cytoplasmic domain of the TGF-β type II receptor in a kinase-dependent manner. To investigate the role of TRIP-1 in mineralized tissues, we examined its pattern of expression in cartilage, bone, and teeth and analyzed the relationship between TRIP-1 overexpression and mineralized matrix formation. Results demonstrate that TRIP-1 was predominantly expressed by osteoblasts, odontoblasts, and chondrocytes in these tissues. Interestingly, TRIP-1 was also localized in the extracellular matrix of bone and at the mineralization front in dentin, suggesting that TRIP-1 is secreted by nonclassical secretory mechanisms, as it is devoid of a signal peptide. In vitro nucleation studies demonstrate a role for TRIP-1 in nucleating calcium phosphate polymorphs. Overexpression of TRIP-1 favored osteoblast differentiation of undifferentiated mesenchymal cells with an increase in mineralized matrix formation. These data indicate an unexpected role for TRIP-1 during development of bone, teeth, and cartilage.
Load modeling by finding support vectors of load data from field measurements

The representation of load dynamic characteristics remains an area of great uncertainty and has become a limiting factor for power system analysis and control. The random nature of the load makes load modeling a very difficult problem, which becomes even more challenging when the field measurements increase and the recorded dataset becomes large. This paper proposes a novel concept of modeling load based on support vectors (SVs) of load data. A three-stage procedure to find SVs of the recorded load dataset is presented. Then the load model is built on the SVs. Although the model is derived from only a small subset of the original dataset, it has a strong generalization capability to describe dynamics of the whole dataset. However, the computational burden on the modeling process is much relieved since only a small subset of data is involved. The proposed method also answers the question on how data should be grouped and how many load models should be built as data are accumulated. This paper infers that, although the data space where the load varies seems indefinite and big, its characteristic can be captured and modeled in a much smaller subspace. The presented method is shown to be effective by the case study on Hushitai substation.
Output Tracking Control for Fuzzy Systems via Static-Output Feedback Design

Over the past decades, many advances have been made in the field of control theory which rely on state-space theory. The control design methodology that has been most investigated for the state-feedback control, see for example [1, 2] and the references therein. The state-feedback control design supposes that all the system states are available, which is not always possible in realistic applications. Instead, one has to deal with the absence of full-state information by using observers. From the control point of view, observers can be used as part of dynamical controllers. This observer-based design has been extensively studied in the literature [3, 4]. However, it leads to high-order controllers. As a matter of fact, one has to solve a large problem, which increases numerical computations for large scale systems. Other difficulties may arise, if we consider additional performances, such as disturbance rejection, time delays, uncertainties, etc. Hence, it is more suitable to develop methodologies which involve a design with a low dimensionality. In this context, intensive efforts have been devoted to design low-order controllers [3, 5–7]. In particular, it has been shown that designing reduced order stabilizing controllers can be cast as a static output-feedback stabilization problem. Also, it is recognized that, in general, the static output-feedback control design may not exist for certain systems. Note that an important advantage of these controllers is that they are easy to implement without significant numerical burden.
Amniotic fluid embolism: Pathophysiology from the perspective of pathology

Amniotic fluid embolism (AFE) is recognized as a type of syndrome characterized by the abrupt onset of hypoxia, hypotension, seizures, or disseminated intravascular coagulopathy (DIC), occurring during labor, delivery, or immediately postpartum, caused by the inflow of amniotic components into the maternal circulation. AFE is a rare condition but one of the most serious obstetrical complications, resulting in a high mortality rate among pregnant women. Despite earlier recognition and intensive critical management, we often encounter patients who unfortunately do not recover from the exacerbation of AFE‐related conditions. A major concern is that there are no effective evidence‐based therapies for AFE, because its pathophysiology is still not well understood. This article reviewed AFE, focusing on the pathology and currently proposed pathophysiology.
Is There a Relationship of Operator and Center Volume With Access Site–Related Outcomes?: An Analysis From the British Cardiovascular Intervention Society

Background—Transradial access is associated with reduced access site–related bleeding complications and mortality post percutaneous coronary intervention. The objective of this study is to examine the relationship between access site practice and clinical outcomes and how this may be influenced by operator and center experience/expertise. Methods and Results—The influence of operator and center experience/expertise was studied on 30-day mortality, in-hospital major adverse cardiovascular events (a composite of in-hospital mortality and in-hospital myocardial infarction and target vessel revascularization) and in-hospital major bleeding based on access site adopted (radial versus femoral). Operator/center experience/expertise were defined by both total volume and transradial access proportion. A total of 164 395 procedures between 2012 and 2013 in the National Health Service in England and Wales were analyzed. After case-mix adjustment, transradial access was associated with an average odds reduction of 39% for 30-day mortality compared with transfemoral access (odds ratio, 0.61; 95% confidence interval, 0.55–0.68; P<0.001). The magnitude of this risk reduction was modified by increases in total procedural volume and radial proportion at the operator level (odds ratio reduction of 11% per 100 extra procedures, 95% confidence interval, 3%–19%; odds ratio reduction of 6% per 10%-point increase in radial proportion, 95% confidence interval, 1%–11%) with no significant impact of operator radial volume, center total volume, center radial volume, and center radial proportion. Conclusions—The lower mortality associated with transradial access adoption relates to both the total procedural volume and the proportion of procedures undertaken radially by operator, with operators undertaking the greatest proportion of their procedures radially having the largest relative reduction in mortality risk.
Posttraumatic stress disorder Part III: health effects of interpersonal violence among women.

TOPIC The aim of this three-part series is to examine the sufficiency of the posttraumatic stress (PTSD) diagnostic construct to capture the full spectrum of human responses to psychological trauma. Part I (Lasiuk & Hegadoren, 2006a) reviewed the conceptual history of PTSD from the nineteenth century to its inclusion in the third edition of the Diagnostic and Statistical Manual of Mental Disorders (American Psychiatric Association, 1980), while Part II (Lasiuk & Hegadoren, 2006b) described subsequent refinements to the original PTSD diagnostic criteria and highlighted subsequent controversies. PURPOSE This paper focuses on interpersonal violence (sexual, physical, and emotional abuse/assault) and its sequelae in women. We argue in support of Judith Herman's (1992) conceptualization of the human trauma response as a spectrum, anchored at one end by an acute stress reaction that resolves on its own without treatment, and on the other by "complex" PTSD, with "classic" or "simple" PTSD somewhere between the two. SOURCES OF INFORMATION he existing theoretical, clinical and research literatures related to humans responses to trauma. CONCLUSION The paper concludes with a call for the need to increase a gendered perspective in all aspects of trauma research and clinical service delivery.
Hydrogen-bonded supramolecular motifs in pyrimethaminium 4-methylbenzoate, pyrimethaminium 3-hydroxypicolinate and pyrimethaminium 2,4-dichlorobenzoate.

In 2,4-diamino-5-(4-chlorophenyl)-6-ethylpyrimidin-1-ium (pyrimethaminium, PMNH) 4-methylbenzoate, C(12)H(14)ClN(4)(+) x C(8)H(7)O(2)(-), (I), pyrimethaminium 3-hydroxypicolinate, C(12)H(14)ClN(4)(+) x C(6)H(4)NO(3)(-), (II), and pyrimethaminium 2,4-dichlorobenzoate, C(12)H(14)ClN(4)(+) x C(7)H(3)Cl(2)O(2)(-), (III), the PMNH cations interact with the carboxylate groups of the corresponding anion via nearly parallel N-H.O hydrogen bonds, forming R(2)(2)(8) ring motifs. A description of the observed arrays of quadruple hydrogen bonds in (I) and (II) in terms of hydrogen donors and acceptors (the DA model), their graph-set motifs and the resulting supramolecular ladder is given. In (III), supramolecular chains along the b axis and helical chains along the a axis are formed via N-H.O hydrogen bonds involving the 2-amino and 4-amino groups of the PMNH cation, respectively. Weak Cl.Cl interactions are also found in (III).
Advances in Brief PART-1 : A Novel Human Prostate-specific , Androgen-regulated Gene that Maps to Chromosome 5 q 121

Genes regulated by androgenic hormones are of critical importance for the normal physiological function of the human prostate gland, and they contribute to the development and progression of prostate carcinoma. We used cDNA microarrays containing 1500 prostate-derived cDNAs to profile transcripts regulated by androgens in prostate cancer cells. This study identified a novel gene that we have designated PART-1 (prostate androgen-regulated transcript 1), which exhibited increased expression upon exposure to androgens in the LNCaP prostate cancer cell line. Northern analysis demonstrated thatPART-1 is highly expressed in the prostate gland relative to other normal human tissues and is expressed as different transcripts using at least three different polyadenylation signals. The PART-1 cDNA and putative protein are not significantly homologous to any sequences in the nonredundant public sequence databases. Cloning and analysis of the putativePART-1promoter region identified a potential binding site for the homeobox gene PBX-1a, but no consensus androgen response element or sterol-regulatory element binding sites were identified. We used a radiation hybrid panel and fluorescencein situ hybridization to map the PART-1 gene to chromosome 5q12, a region that has been suggested to harbor a prostate tumor suppressor gene. These results identify a new gene involved in the androgen receptor-regulated gene network of the human prostate that may play a role in the etiology of prostate carcinogenesis.
Citizen Adoption of E-Government Services: Exploring Citizen Perceptions of Online Services in the United States and United Kingdom

ABSTRACT This study presents a cross-national examination of e-government adoption in the United Kingdom and the United States. The results of partial least squares analysis indicate that disposition to trust is positively related to internet trust and government trust. Perceived ease of use and perceived usefulness have a significant impact on intention to use. Internet trust has a positive effect on intention to use. We conclude by highlighting cultural differences in e-government adoption.