Miracle-dz/UniFAR-FTUs huggingface dataset:
Development of a novel amphibious locomotion system for use in intra-luminal surgical procedures

Colonoscopy is widely considered the gold standard for inspection of the colon. The procedure is however not without issue, current colonoscopes have seen little change or innovation throughout their 40 years of use with patient discomfort still limiting success. The aim of this PhD study was to develop a locomotion system for use on a robotic device that can traverse a liquid filled colon for atraumatic inspection and biopsy tasks. The PhD was undertaken as part of a larger two-centre EU project, which aimed to bring about a change in the way colonoscopy is done by moving to “robotic hydro-colonoscopy”. In this thesis the initial development and testing of an amphibious locomotion concept for use in a procedure known as hydro-colonoscopy is described. The locomotion system is comprised of four Archimedes’ screws arranged in two counter-rotating pairs. These aim to provide propulsion through a fluid-filled colon as well as provide locomotive traction against colonic tissue in partially fluid-filled or collapsed sections of the colon, such as the splenic flexure. Experimental studies were carried out on a single screw system in fluid and dual counter-rotating screws in contact conditions. These show the system’s ability to generate thrust in the two discrete modes of locomotion of the amphibious system. A 2:1 scale prototype of the proposed device was produced and features compliant screw threads to provide atraumatic locomotion. The scale prototype device was tested in ex-vivo porcine colon. The developed system was able to traverse through lumen to limited success, which demonstrated that this concept has the potential for use on an intra-luminal robotic device The key contributions of this research are: variable geometry locomotion system; amphibious locomotion using Archimedes’ screws; experimental assessment of the locomotion in fluid, contact and amphibious states; and analysis of the contact dynamics against tissue.
Implications of Mediated Market Access—Exploring the Nature of Vertical Relationships within the Croatian Wine Industry

The aim of this research was to provide a better understanding of factors influencing the performance of (small) agricultural producers. Considering the importance of agricultural producers, not just for maintaining a steady supply of products but also for the preservation of the population (and cultural tradition) of rural areas, the development of sustainable agricultural business is a matter of public interest. This paper considers wine producers and their market channels, i.e., the factors influencing the relationship between wine producers and market intermediaries, by applying ideas taken from agency theory. We developed a conceptual model with our defined measure of agency costs as the mediator variable between multiple regressors and the firms’ financial and non-financial performance as regressions. We used the approach of Baron and Kenny to investigate whether agency costs act as a mediator variable. The data needed to test the proposed conceptual model were collected through questionnaires and contextual interviews with the Croatian wine producers (n = 124). We found that more self-reliance in the distribution process, supported by factors related to the bargaining strength, had a positive influence on wine producers’ performance. The results also support the assumption that agency costs act as a full mediator variable between a producer’s attributes and its performance.
A Novel Gonadotropic Microsporidian Parasite (Microsporidium clinchi n. sp.) Infecting a Declining Population of Pheasantshell Mussels (Actinonaias pectorosa) (Unioinidae) from the Clinch River, USA

Freshwater mussels of the order Unionida are among the most endangered animal groups globally, but the causes of their population decline are often enigmatic, with little known about the role of disease. In 2018, we collected wild adult pheasantshell (Actinonaias pectorosa) and mucket (Actinonaias ligamentina) during an epidemiologic survey investigating an ongoing mussel mass mortality event in the Clinch River, Virginia and Tennessee, USA. Histopathology and transmission electron microscopy showed a novel microsporidian parasite primarily infecting the ovary of pheasantshell. Sequencing of the small subunit rRNA gene produced a 1333 bp sequence with the greatest similarity to Pseudonosema cristatellae (AF484694.1; 86.36%; e-value = 0), a microsporidium infecting the freshwater bryozoan (Cristatella mucedo). Microsporidia were observed in 65% (17/26) of the examined female pheasantshell (A. pectorosa) and in no (0/2) female muckets (A. ligamentina) and occurred at mortality and non-mortality sites. Our findings indicate that a novel parasite, Microsporidium clinchi n. sp. , is present in pheasantshell in the Clinch River, and while likely not a cause of mass mortality, could reduce fecundity and recruitment in this declining population and threaten the success of reintroductions. Surveillance of M. clinchi n. sp. and evaluation of broodstock and their progeny for microsporidia would therefore be prudent.
Efficacy of High-Dose Polyclonal Intravenous Immunoglobulin in COVID-19: A Systematic Review

Background: Although several therapeutic strategies have been investigated, the optimal treatment approach for patients with coronavirus disease (COVID-19) remains to be elucidated. This systematic review and meta-analysis aimed to evaluate the efficacy and safety of polyclonal intravenous immunoglobulin (IVIG) therapy in COVID-19. Methods: A systematic literature search using appropriate medical subject heading (MeSH) terms was performed through Medline (PubMed), EMBASE, SCOPUS, OVID and Cochrane Library electronic databases. The main outcomes considered were mortality and safety of IVIG versus placebo/standard of care. This review was carried out in accordance with Cochrane methodology including the risk bias assessment and grading of the quality of evidence. Measures of treatment effect were mean differences (MD) together with 95% confidence intervals (CIs) for continuous outcome measures and risk ratio (RR) or MD for binary outcomes. Two reviewers independently extracted data from individual studies, and disagreements were resolved by a third reviewer. Results: A total of 2401 COVID-19 patients from 10 studies (four randomized controlled trials (RCT) and six non-randomized controlled trials (non-RCTs)) were included in the analysis. Participants received IVIG or placebo/standard of care. The use of IVIG was not associated with a significantly reduced risk of death (RR 0.50, 95% CIs 0.18–1.36, p = 0.17 for RCTs; RR 0.95, 95% CIs 0.61–1.58, p = 0.94 for non-RCTs; low certainty of evidence). IVIG significantly reduced the length of hospital stay (MD −2.24, 95% CIs −3.20/−1.27; p = 0.00001; low certainty of evidence), although this difference was significant only for studies evaluating moderate COVID-19 patients. No significant difference was observed in the incidence of overall and serious adverse events between IVIG recipients and controls (very low certainty of evidence). Conclusions: The current evidence from the literature does not support the use of IVIG in COVID-19 patients.
RANDOM VIBRATION FATIGUE LIFE VISUALIZATION PROGRAM DEVELOPMENT BASED ON ANSYS SECONDARY PROGRAM

In order to solve the calculation of the vibration frequency,the results superposition of the three directions vibration and the visual display of the whole domain,the Ansys secondary program has been developed. The program has been implicated in a converter device,the results indicates that it can be more rapid,comprehensive and efficient to analyze fatigue life,theoretical guidance can be provided for the optimization of product structure design.
Simulated event‐scale flow and sediment generation responses to agricultural land cover change in lowland UK catchments

Agricultural land use can increase runoff and erosion leading to detrimental downstream impacts. This paper examines the impact of agricultural land cover change on runoff and sediment generation at event scales using a model‐based approach. SHETRAN, a physically based, spatially distributed model, was applied in two southwest England catchments to represent: (a) changes in the land cover (cropland extent and spatial arrangement), (b) changes in crop type and (c) use of riparian buffer strips. A total of 84 simulated events within a 4‐year period were used to quantify impacts on flow and sediment generation. We found past changes in land cover resulted in significant differences in sediment yield (p < 0.05). Linear regression showed an increase in flow and sediment yield proportional to increases in arable crop area (p < 0.001). The spatial arrangement of cropped fields and riparian buffer strips produced no significant differences in event flow or sediment yield (p > 0.05). However, buffer strip scenarios compared with the base run showed sediment load reductions for specific events, up to 20% and 15% for woodland and grass riparian buffers, respectively. When comparing crop types with and without the use of post‐harvest cover crops, we observed non‐significant differences for event flow and sediment yield. However, large reductions in modelled sediment yields occurred for some events (e.g., up to 60% for winter cereals, 50% for maize and 74% for spring cereals). For these scenarios, examination of rainfall event magnitude emphasized the importance of ground cover in mitigating soil erosion for maize and spring cereals, but not for winter cereals. Our findings indicate that significant changes in sediment delivery at the event scale over a multi‐year period are associated with variations in cropland extent and crop types, depending on rainfall magnitude, but not on the spatial arrangement of cropped fields or the use of riparian buffer strips.
Supervisor Bottom-Line Mentality and Knowledge Hiding: A Moderated Mediation Model

Organizations need to respond to multiple demands, not only of shareholders but of stakeholders. Supervisor mentality that focuses on bottom-line goals, such as financial performance, can result in negative consequences. We used conservation of resources theory to examine how and when employees engage in knowledge hiding toward coworkers was influenced by supervisor bottom-line mentality. A two-wave survey (N = 274) revealed a positive impact of supervisor bottom-line mentality on knowledge hiding toward coworkers via prevention-based psychological ownership. Further, the higher the competitive psychological climate, the stronger the positive relationship between supervisor bottom-line mentality and knowledge hiding via prevention-based psychological ownership. Our study highlights the negative effect of supervisor bottom-line mentality on knowledge transfer among employees.
Catalytic Production of Levulinic and Formic Acids from Fructose over Superacid ZrO2–SiO2–SnO2 Catalyst

Catalytic conversion of fructose to levulinic and formic acids over tin-containing superacid (H0 = −14.52) mixed oxide was studied. Mesoporous ZrO2–SiO2–SnO2 (Zr:Si:Sn = 1:2:0.4) was synthesized by the sol–gel method. The fructose transformation was carried out in a rotated autoclave at 160–190 °C for 1–5 h using a 20 wt. % aqueous solution. The results showed that doping ZrO2–SiO2 samples with Sn4+ ions improved both fructose conversion and selectivity toward levulinic and formic acids. Under optimal conditions of 180 °C, 3.5 h and fructose to catalyst weight ratio 20:1, levulinic and formic acids yields were 80% and 90%, respectively, at complete fructose conversion. At this, humic substances formed in the quantity of 10 wt. % based on the target products.
Production performance and egg quality evaluation of indigenous chickens across different agro-ecologies of Southern Ethiopia

Indigenous chickens were evaluated for their egg production, growth performances, and external and internal egg quality parameters across three agro-ecologies. For experiment 540 (180 male and 432 female) chickens were distributed to the three agro-ecologies (lowland, midland, and highland) at their 20 weeks age. Body weight was recorded from each chicken during distribution, 4th week, and 8th week after distribution into pre-selected households. Egg production potential was identified from the indigenous chickens across different agro-ecologies. Moreover, egg quality traits were evaluated from randomly selected 270 (90 from each agroecology) eggs. Egg production of indigenous chickens in the highland was 47.7 which was highly significantly (P = 0.0001) lower number than of midland (54.2) and lowland (51.4). Except for Shell weight, all the external egg quality parameters evaluated were exhibited significant differences across different agro-ecologies. Among the internal egg quality parameters only albumen weight had a significantly (P = 0.007) higher in midland than highland. Most of the variation in egg weight was due to the positive correlation with egg length (69%), and egg width (67%). There was a variation for performance and egg quality traits of indigenous chickens in different agro-ecologies, especially better in midland, which might be resulted from the variation in environment, feed resources availability, and better management followed by households.
Fluctuation in Germination on Exposure to Salt Stress in Trifolium Alexandrium L. in
Cultivars

Trifolium alexandrinum L. is a leguminuous plant having tremendous nutritional values associated with it to be utilized as cattle feed. The germination is affected by different factors and one of them being the water absorption capacity of seeds for initial germination. In our study three cultivars of T. alexandrinum viz. BB1 BB2 BB3 were selected and their corresponding seeds were germinated under Na2SO4 stress. The salt concentration chosen for the study ranged from 0 mM, 25 mM, 50 mM, 75 mM, 100 mM, and 150 mM. The study revealed that the salt concentration 0 mM, 25 mM, 50 mM were not having pronounced effect but upon increasing the salt concentration the rate of germination decreased and hence the radical, plumule and cotyledonary leaf also was drastically reduced
Deep Learning Autoencoder-based Compression for Current Source Model Waveforms

Modeling complex cell behavior is critical for accurate static timing analysis. Huge waveform data needed for current source models explodes technology file size and degrades design flow performance. We used deep learning nonlinear Autoencoders to compress voltage and current waveforms and compared them with singular component analysis approach. Autoencoders gave up to 3.37x compression ratio for voltage waveforms with average percentage error below 0.85% better than SVD approach. Autoencoders achieved 1.7x compression ratio for complex rising-edge current waveforms at model loss of 7.6e-5 and comparable results to SVD approach for the falling-edge waveforms. SVD remains more computationally efficient than Autoencoders.
Inhibitory Control in Children with Tourette Syndrome Is Impaired in Everyday Life but Intact during a Stop Signal Task

Tourette Syndrome (TS) has previously been associated with deficits in inhibitory control (IC). However, studies on IC in individuals with TS have produced conflicting results. In the present study, we investigated IC, comparing the Stop Signal Reaction Time (SSRT) measure with parent and teacher ratings of daily life IC in 169 children aged 8–12 (60 with TS, 60 typically developing controls, 27 with attention-deficit/hyperactivity disorder (ADHD), and 22 with TS + ADHD). We further investigated associations of IC with TS and ADHD symptom severity. Children with TS showed intact SSRT performance, but impairments in daily life IC, as reported by parents and teachers. For the latter, we observed a staircase distribution of groups, with the healthy controls presenting with the best IC, followed by TS, TS + ADHD, and finally ADHD. Dimensional analyses indicated a strong association between ADHD severity and both measures of IC. Our results indicate that children with TS are not impaired in a laboratory-based measure of IC, although some difficulties were evident from measures of everyday behaviour, which may in part be due to parents and teachers interpreting tics as disinhibited behaviour. Comorbid ADHD or the severity of subthreshold ADHD symptomatology appeared to account for IC deficits.
Evaluation of a Peroxide-Based Algaecide for Cyanobacteria Control: A Mesocosm Trial in Lake Okeechobee, FL, USA

A 72 h small-scale trial was conducted in enclosed mesocosms in the Lake Okeechobee waterway to evaluate the effectiveness of a USEPA-registered peroxide-based algaecide (formulated as sodium carbonate peroxyhydrate) for controlling a natural cyanobacteria population. Mesocosms were initially subjected to either no algaecide or the maximum label rate of 10 mg H2O2·L−1. A subset of mesocosms were then subjected to a sequential application of 5 mg H2O2·L−1 at 48 h after initial treatment. Following application, peroxide concentrations rapidly decreased and were undetectable by 48 h. At 24 h after treatment, significant decreases in all biomass indicators were observed (compared to untreated mesocosms), including extracted chlorophyll a, microscopic counts (total phytoplankton and total cyanobacteria), and cyanobacteria-specific 16S rRNA gene copies by over 71%. Although peroxide treatment reduced cyanobacteria biomass, there was no change in overall community structure and the remaining population was still dominated by cyanobacteria (>90%). After 48 h exposure, some biomass recovered in single application mesocosms resulting in only a 32–45% reduction in biomass. Repeated peroxide dosing resulted in the greatest efficacy, which had a sustained (60–91%) decrease in all biomass indicators for the entire study. While a single application of the peroxide was effective in the first 24 h, a sequential treatment is likely necessary to sustain efficacy when using this approach to manage cyanobacteria in the field. Results of this study support that this peroxide-based algaecide is a strong candidate to continue with scalable field trials to assess its potential future utility for operational management programs in the Lake Okeechobee waterway.
Characterising the area under the curve loss function landscape

One of the most common metrics to evaluate neural network classifiers is the area under the receiver operating characteristic curve (AUC). However, optimisation of the AUC as the loss function during network training is not a standard procedure. Here we compare minimising the cross-entropy (CE) loss and optimising the AUC directly. In particular, we analyse the loss function landscape (LFL) of approximate AUC (appAUC) loss functions to discover the organisation of this solution space. We discuss various surrogates for AUC approximation and show their differences. We find that the characteristics of the appAUC landscape are significantly different from the CE landscape. The approximate AUC loss function improves testing AUC, and the appAUC landscape has substantially more minima, but these minima are less robust, with larger average Hessian eigenvalues. We provide a theoretical foundation to explain these results. To generalise our results, we lastly provide an overview of how the LFL can help to guide loss function analysis and selection.
Hippocampal Expression of Cytochrome P450 1B1 in Penetrating Traumatic Brain Injury

Hippocampal dysfunction contributes to multiple traumatic brain injury sequala. Female rodents’ outcome is superior to male which has been ascribed the neuroprotective sex hormones 17β-estradiol and progesterone. Cytochrome P450 1B1 (CYP1B1) is an oxidative enzyme influencing the neuroinflammatory response by creating inflammatory mediators and metabolizing neuroprotective 17β-estradiol and progesterone. In this study, we aimed to describe hippocampal CYP1B1 mRNA expression, protein presence of CYP1B1 and its key redox partner Cytochrome P450 reductase (CPR) in both sexes, as well as the effect of penetrating traumatic brain injury (pTBI). A total 64 adult Sprague Dawley rats divided by sex received pTBI or sham-surgery and were assigned survival times of 1-, 3-, 5- or 7 days. CYP1B1 mRNA was quantified using in-situ hybridization and immunohistochemistry performed to verify protein colocalization. CYP1B1 mRNA expression was present in all subregions but greatest in CA2 irrespective of sex, survival time or intervention. At 3-, 5- and 7 days post-injury, expression in CA2 was reduced in male rats subjected to pTBI compared to sham-surgery. Females subjected to pTBI instead exhibited increased expression in all CA subregions 3 days post-injury, the only time point expression in CA2 was greater in females than in males. Immunohistochemical analysis confirmed neuronal CYP1B1 protein in all hippocampal subregions, while CPR was limited to CA1 and CA2. CYP1B1 mRNA is constitutively expressed in both sexes. In response to pTBI, females displayed a more urgent but brief regulatory response than males. This indicates there may be sex-dependent differences in CYP1B1 activity, possibly influencing inflammation and neuroprotection in pTBI.
Development of 3D-Printed, Liquisolid and Directly Compressed Glimepiride Tablets, Loaded with Black Seed Oil Self-Nanoemulsifying Drug Delivery System: In Vitro and In Vivo Characterization

Glimepiride is characterized by an inconsistent dissolution and absorption profile due to its limited aqueous solubility. The aim of this study was to develop glimepiride tablets using three different manufacturing techniques, as well as to study their quality attributes and pharmacokinetics behavior. Black seed oil based self-nanoemulsifying drug delivery system (SNEDDS) formulation was developed and characterized. Glimepiride liquisolid and directly compressed tablets were prepared and their pre-compression and post-compression characteristics were evaluated. Semi-solid pastes loaded with SNEDDS were prepared and used to develop three-dimensional printing tablets utilizing the extrusion technique. In vivo comparative pharmacokinetics study was conducted on Male Wistar rats using a single dose one-period parallel design. The developed SNEDDS formulation showed a particle size of 45.607 ± 4.404 nm, and a glimepiride solubility of 25.002 ± 0.273 mg/mL. All the studied tablet formulations showed acceptable pre-compression and post-compression characteristics and a difference in their in vitro drug release behavior. The surface of the liquisolid and directly compressed tablets was smooth and non-porous, while the three-dimensional printing tablets showed a few porous surfaces. The inner structure of the liquisolid tablets showed some cracks and voids between the incorporated tablet ingredients while that of the three-dimensional printing tablets displayed some tortuosity and a gel porous-like structure. Most of the computed pharmacokinetic parameters improved with the liquisolid and three-dimensional printed tablets. The relative bioavailabilities of the three-dimensional printed and liquisolid tablets compared to commercial product were 121.68% and 113.86%, respectively. Therefore, the liquisolid and three-dimensional printed tablets are promising techniques for modifying glimepiride release and improving in vivo performance but more clinical investigations are required.