Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of a 3-Week In-Hospital Body Weight Reduction Program on Cardiovascular Risk Factors, Muscle Performance, and Fatigue: A Retrospective Study in a Population of Obese Adults with or without Metabolic Syndrome

Background. In clinical practice, there is the diffuse conviction that obese subjects with metabolic syndrome may be more difficult to treat. Objectives and Methods. The aim of the present study was that to investigate the effectiveness of a 3-week in-hospital body weight reduction program (BWRP) in a large population of obese subjects with and without metabolic syndrome (n = 1922; 222 men and 1700 women, age range 18–83 yr). Outcomes such as body mass index (BMI), total (TOT) and HDL cholesterol, systolic and diastolic blood pressures (SBP and DBP, respectively), coronary heart disease (CHD) score, fatigue severity score (FSS), and stair climbing test (SCT) time were evaluated before and after the intervention (Δ). A sex-, BMI-, and age-related stratification of the obese population with or without metabolic syndrome was applied. Results. When compared to obese subjects without metabolic syndrome, at the basal conditions, obese subjects had a poorer cardiometabolic profile, as demonstrated by higher triglycerides, TOT-cholesterol, DBP, SBP, and CHD score, and a more compromised muscle performance (evaluated by SCT), associated with more perception of fatigue (measured by FSS). Nevertheless, obese subjects with metabolic syndrome obtained more benefits from BWRP than those without metabolic syndrome for some outcomes (i.e., ΔTOT-cholesterol, ΔSBP, and ΔCHD score). Despite these differences, the BWRP-induced weight loss was similar between the two groups (i.e., ΔBMI) as well as the gain of muscle performance (i.e., ΔSCT) and the reduction of fatigue (i.e., ΔFSS). Interestingly, the potentially deleterious fall in HDL-cholesterol levels after BWRP was less evident in obese subjects with metabolic syndrome than those without metabolic syndrome. When pooling all data, the ΔCHD score was associated with age, sex, and metabolic syndrome. The remaining outcomes, such as ΔBMI, ΔFSS, and ΔSCT time, were associated with sex and age but not with metabolic syndrome. Finally, ΔBMI was positively correlated with ΔCHD score, ΔFSS, and ΔSCT time in both obese subjects without metabolic syndrome and obese subjects with metabolic syndrome. Conclusions. When comparing obese subjects undergoing a BWRP, metabolic syndrome is not a negative predictive factor affecting the effectiveness of this intervention in terms of weight loss, muscle performance, and psychological well-being.
Simulation of Disturbance Recovery Based on MPC and Whole-Body Dynamics Control of Biped Walking

Biped robots are similar to human beings and have broad application prospects in the fields of family service, disaster rescue and military affairs. However, simplified models and fixed center of mass (COM) used in previous research ignore the large-scale stability control ability implied by whole-body motion. The present paper proposed a two-level controller based on a simplified model and whole-body dynamics. In high level, a model predictive control (MPC) controller is implemented to improve zero moment point (ZMP) control performance. In low level, a quadratic programming optimization method is adopted to realize trajectory tracking and stabilization with friction and joint constraints. The simulation shows that a 12-degree-of-freedom force-controlled biped robot model, adopting the method proposed in this paper, can recover from a 40 Nm disturbance when walking at 1.44 km/h without adjusting the foot placement, and can walk on an unknown 4 cm high stairs and a rotating slope with a maximum inclination of 10°. The method is also adopted to realize fast walking up to 6 km/h.
Best linear unbiased prediction of maize single-cross performance

In preliminary studies, best linear unbiased prediction (BLUP) has been found useful for identifying high-yielding maize (Zea mays L.) single crosses prior to field evaluation. In this study, the effectiveness of BLUP for large-scale prediction of yield, moisture, stalk lodging, and root lodging was investigated. Multilocation data from 1990 to 1994 were obtained from the hybrid testing program of Limagrain Genetics. For each of 16 heterotic patterns, the performance of m untested single crosses was predicted from the performance of n tested single crosses as y M = C MP C PP -1 y P , where y M = m x 1 vector of predicted performance of the untested single crosses ; C MP = m x n matrix of genetic covariances between the untested single crosses and the tested single crosses ; C PP = n x n phenotypic covariance matrix among the tested single crosses ; and y P = n x 1 vector of average performance of the tested single crosses, corrected for yield trial effects. Correlations between predicted and observed performance were obtained with a delete-one cross-validation procedure. For heterotic patterns with large (>100) numbers of tested single crosses, the correlations ranged from 0.426 to 0.762 for yield, 0.754 to 0.933 for moisture, 0.300 to 0.739 for stalk lodging, and 0.164 to 0.532 for root lodging. The correlations, especially for lodging traits, increased as larger numbers of tested single crosses were available. The results in this study were obtained from large and diverse data sets (600 inbreds, 15 183 data points, and 4099 tested single crosses across 16 heterotic patterns) and provide strong evidence that BLUP is useful for routine identification of superior single crosses prior to field testing.
Quick Marination of Anchovies (Engraulis enchrasicolus) Using Acetic and Gluconic Acids. Quality and Stability of the End Product

Abstract Anchovy fillets were simultaneously salted and pickled by soaking in acid and salt mixed solutions at low temperature. Three different acidic solutes were tested (acetic acid; gluconic acid; both acetic and gluconic acids). The process was optimized to obtain the same final characteristics in terms of salt content and pH for the three different end-products. A comparative study was performed to evaluate the influence of the type of acid on the microbial, physicochemical and sensory qualities of the product after pickling and during storage. The use of both acetic and gluconic acids is an interesting option to moderate sour and salty tastes, in response to current consumer expectations, without affecting the product decontamination level and shelf-life.
An Integrated Genomic Strategy to Identify CHRNB4 as a Diagnostic/Prognostic Biomarker for Targeted Therapy in Head and Neck Cancer

Although many studies have shown the association between smoking and the increased incidence and adverse prognosis of head and neck squamous cell carcinoma (HNSCC), the mechanisms and pharmaceutical targets involved remain unclear. Here, we integrated gene expression signatures, genetic alterations, and survival analyses to identify prognostic indicators and therapeutic targets for smoking HNSCC patients, and we discovered that the FDA-approved drug varenicline inhibits the target for cancer cell migration/invasion. We first identified 18 smoking-related and prognostic genes for HNSCC by using RNA-Seq and clinical follow-up data. One of these genes, CHRNB4 (neuronal acetylcholine receptor subunit beta-4), increased the risk of death by approximately threefold in CHRNB4-high expression smokers compared to CHRNB4-low expression smokers (log rank, p = 0.00042; hazard ratio, 2.82; 95% CI, 1.55–5.14), former smokers, and non-smokers. Furthermore, we examined the functional enrichment of co-regulated genes of CHRNB4 and its 246 frequently occurring copy number alterations (CNAs). We found that these genes were involved in promoting angiogenesis, resisting cell death, and sustaining proliferation, and contributed to much worse outcomes for CHRNB4-high patients. Finally, we performed CHRNB4 gene editing and drug inhibition assays, and the results validate these observations. In summary, our study suggests that CHRNB4 is a prognostic indicator for smoking HNSCC patients and provides a potential new therapeutic drug to prevent recurrence or distant metastasis.
Analysis of the Force-Velocity Profile in Female Ballet Dancers

Jumping ability has been identified as one of the best predictors of dance performance. The latest findings in strength and conditioning research suggest that the relationship between force and velocity mechanical capabilities, known as the force-velocity profile, is a relevant parameter for the assessment of jumping ability. In addition, previous investigations have suggested the existence of an optimal force-velocity profile for each individual that maximizes jump performance. Given the abundance of ballistic actions in ballet (e.g., jumps and changes of direction), quantification of the mechanical variables of the force-velocity profile could be beneficial for dancers as a guide to specific training regimens that can result in improvement of either maximal force or velocity capabilities. The aim of this study was to compare the mechanical variables of the force-velocity profile during jumping in different company ranks of ballet dancers. Eighty-seven female professional ballet dancers (age: 18.94 ± 1.32 years; height: 164.41 ± 8.20 cm; weight: 56.3 ± 5.86 kg) showed high force deficits (> 40%) or low force deficits (10% to 40%) regardless of their company rank. Our results suggest that dance training mainly develops velocity capabilities, and due to the high number of dramatic elevations that dance performance requires, supplemental individualized force training may be beneficial for dancers. The individualization of training programs addressed to the direction of each individuals imbalance (high force or low force) could help dancers and their teachers to improve jump height and therefore dance performance.
Inhibition of Selectin Function and Leukocyte Rolling Protects Against Dextran Sodium Sulfate-Induced Murine Colitis

Background: The selectin family of adhesion molecules (P-, E- and L-selectin) plays an important role in inflammatory reactions by mediating interactions between leukocytes and activated endothelial cells. However, a recent study using gene-targeted mice has suggested that adhesion molecules (P- and Eselectin and ICAM-1) may not be relevant targets in intestinal inflammation. The objective of the present study was to re-evaluate the potential role of selectins in experimental colitis in wild-type mice using the polysaccharide fucoidan, which inhibits the function of P- and L-selectin. Methods: For this purpose, Balb/c mice were exposed to 5% dextran sodium sulfate (DSS) in the drinking water for 5 days with and without daily administration of fucoidan (25 mg/kg, i.v.). In separate experiments, the effect of fucoidan on leukocyte-endothelium interactions was examined by use of intravital microscopy. Results:
Fear of Negative Evaluation and Student Anxiety in Community College Active-Learning Science Courses

Student anxiety is a growing concern for colleges and universities. As science classrooms transition from traditional lecture to active learning, researchers have sought to understand how active learning affects undergraduate anxiety. However, although community colleges educate nearly half of all undergraduates, no studies have explored the relationship between anxiety and active learning in the context of community college science courses. In this study, we interviewed 29 students enrolled across nine community colleges in the southwestern United States to probe factors that increase and decrease their anxiety in active-learning science courses. Using inductive coding, we identified a set of common factors that affect community college student anxiety in active learning. We found that community college student anxiety decreased when students perceived that active-learning activities enhanced their learning by providing them with multiple ways of learning or the opportunity to learn from others. We also identified fear of negative evaluation as the primary construct underlying student anxiety in active learning and described factors that mediated students’ fear of negative evaluation in the community college science classroom. This work highlights how instructors can create more inclusive active-learning science classrooms by reducing student anxiety during active-learning instruction.
Genetic Diversity and Population Structure in the Kuskokwim River Drainage Support the Recurrent Evolution Hypothesis for Sockeye Salmon Life Histories

Abstract Riverine sockeye salmon Oncorhynchus nerka (those that do not use nursery lakes for juvenile rearing) tend to be characterized by greater genetic diversity and weaker population structure than lake-type populations. These findings have led to the “recurrent evolution” hypothesis for sockeye salmon life histories, which proposes that riverine sockeye salmon are the principal colonizing form and play the dominant role in the long-term persistence of sockeye salmon in a dynamic landscape. However, previous studies in Kamchatka (Russia) and Alaska have suggested that the general patterns of riverine sockeye salmon do not apply in all parts of the species' range. In this study, we examined genetic diversity and population structure in lake-type and riverine sockeye salmon from the Kwethluk and Holitna rivers (Kuskokwim drainage, western Alaska), near the northern edge of the species' range in North America. As expected, lake-type sockeye salmon exhibited lower genetic diversity and stronger genetic st.
Efficacy of therapeutic plasma exchange in severe COVID‐19 patients

Coronavirus disease 2019 (COVID-19) could lead to a sharp increase in the levels of inflammatory cytokines. We report the efficacy of therapeutic plasma exchange in severe COVID-19 patients with acute respiratory distress syndrome. The results suggested TPE could be used as a strategy to attenuate circulating cytokines and inflammatory mediators.
Phosphoinositide Binding Inhibits α-Actinin Bundling Activity*

α-Actinin is an abundant actin-bundling and adhesion protein that directly links actin filaments to integrin receptors. Previously, in platelet-derived growth factor-treated fibroblasts, we demonstrated that phosphoinositides bind to α-actinin, regulating its localization (Greenwood, J. A., Theibert, A. B., Prestwich, G. D., and Murphy-Ullrich, J. E. (2000) J. Cell Biol. 150, 627– 642). In this study, phosphoinositide binding and regulation of α-actinin function is further characterized. Phosphoinositide binding specificity, determined using a protein-lipid overlay procedure, suggests that α-actinin interacts with phosphates on the 4th and 5th position of the inositol head group. Binding assays and mutational analyses demonstrate that phosphoinositides bind to the calponin homology domain 2 of α-actinin. Phosphoinositide binding inhibited the bundling activity of α-actinin by blocking the interaction of the actin-binding domain with actin filaments. Consistent with these results, excessive bundling of actin filaments was observed in fibroblasts expressing an α-actinin mutant with decreased phosphoinositide affinity. We conclude that the interaction of α-actinin with phosphoinositides regulates actin stress fibers in the cell by controlling the extent to which microfilaments are bundled.
Thinking avant la lettre: A Review of 4E Cognition

Abstract The “4E” approach to cognition argues that cognition does not occur solely in the head, but is also embodied, embedded, enacted, or extended by way of extra-cranial processes and structures. Though very much in vogue, 4E cognition has received relatively few critical evaluations. By reflecting on two recent collections, this article reviews the 4E paradigm with a view to assessing its strengths and weaknesses.
Phenolic Composition and Browning Susceptibility of Various Apple Cultivars at Maturity

Phenolic compounds and polyphenol oxidase (PPO) activity in the fruits of 11 apple cultivars before and after bruising were studied in relation to their susceptibility to browning. The degree of browning has been determined by the simultaneous measurements of soluble (absorbance at 400 nm) and insoluble (lightness) brown pigments. The sum of these two expressing the extent of browning, closely correlated with the amount of phenolics (hydroxycinnamic derivatives and flavan-3-ols) degraded. Maturity did not appear to greatly influence the development of browning.
Storage of sea urchin gonad in oxygenated sea water.

塩水ウニ生殖腺の貯蔵中における ATP 関連化合物の変化を追跡した。 時間経過に伴い，全ヌクレオチド量に対する ATP の割合は低下し，商業的鮮度指標である海水の濁りが増加した。 このことから，塩水ウニの鮮度は全ヌクレオチド量に対する ATP の割合で評価できると判断した。 これを指標に酸素共存下での塩水ウニの鮮度変化を追跡したところ，酸素量が多いほど生殖腺の ATP 含量が高く保持され，外観的に海水の濁り発生が抑制された。 この間微生物の増殖は認められなかった。 酸素を供給した貯蔵は塩水ウニの鮮度保持に有効と結論した。
Development of an In Situ Analyzer Based on Sequential Injection Analysis and Liquid Waveguide Capillary Flow Cell for the Determination of Dissolved Reactive Phosphorus in Natural Waters

This study presents an innovative technique for the in situ analysis of aquatic biochemical elements detected through wet chemical processes. A new compact in situ phosphate analyzer based on sequential injection analysis, liquid waveguide capillary flow cell and spectrophotometry was developed, and a safe and modular electronics-chemical separation mechanical structure was designed. The sequential injection system of this analyzer was optimized, and the major functions of this analyzer were studied and estimated. With a 10 cm liquid waveguide capillary flow cell and a 6.3 min time cost of detection, the analyzer reaches a detection limit of 1.4 μg·L−1 (≈14.7 nM, [PO43−]) and a consumption of 23 μL at most for each reagent. This analyzer was operated in situ and online during two scientific research cruises in the Pearl River Estuary and northern South China Sea. The advantages of this analyzer include its simple versatile manifold, full automation, low chemical consumption and electronics-chemical separate safe structure. Long-term in situ performance of this analyzer will be validated in the future.
Simultaneous Hand Gesture Classification and Finger Angle Estimation via a Novel Dual-Output Deep Learning Model

Hand gesture classification and finger angle estimation are both critical for intuitive human–computer interaction. However, most approaches study them in isolation. We thus propose a dual-output deep learning model to enable simultaneous hand gesture classification and finger angle estimation. Data augmentation and deep learning were used to detect spatial-temporal features via a wristband with ten modified barometric sensors. Ten subjects performed experimental testing by flexing/extending each finger at the metacarpophalangeal joint while the proposed model was used to classify each hand gesture and estimate continuous finger angles simultaneously. A data glove was worn to record ground-truth finger angles. Overall hand gesture classification accuracy was 97.5% and finger angle estimation R2 was 0.922, both of which were significantly higher than shallow existing learning approaches used in isolation. The proposed method could be used in applications related to the human–computer interaction and in control environments with both discrete and continuous variables.
Predicting livestock productivity and methane emissions in northern Australia: development of a bio-economic modelling approach

Enteric fermentation from livestock is a large source of methane, which has a global warming potential 23 times that of carbon dioxide. In Australia, enteric emissions from the livestock sector contribute 10% of Australia’s greenhouse gases. The northern Australian beef industry about 16 million animals is a major contributor to these emissions. However, relative to temperate systems, comparatively little research has been conducted on enteric methane emissions from tropical feeding systems. This paper describes a modelling approach that estimates cattle methane emissions for various bioregions of northern Australia. The approach incorporates a metabolisable energy based model of animal production linked to a property herd economic model. This provides a flexible tool to evaluate animal and property herd dynamics on regional methane yields and liveweight productivity, as well as to assess financial impacts. The model predicts that an important determinant of methane output per unit of product is reduced days to market. Reduced days to market may be achieved through a range of energy supplementation and marketing strategies.
Dual-Task Effects on Performance of Gait and Balance in People with Knee Pain: A Systematic Scoping Review

Dual-task paradigms have been increasingly used to assess the interaction between cognitive demands and the control of balance and gait. The interaction between functional and cognitive demands can alter movement patterns and increase knee instability in individuals with knee conditions, such as knee anterior cruciate ligament (ACL) injury or osteoarthritis (OA). However, there is no consensus on the effects of dual-task on gait mechanics and balance in those individuals. This systematic scoping review aims to examine the impact of dual-task gait and standing balance on motor and cognitive performance in individuals with knee OA or ACL injury. A comprehensive search of MEDLINE, PubMed, Web of Science, and EMBASE electronic databases up until December 2019 was carried out. Inclusion criteria was limited to include dual-task studies that combined cognitive tasks performed simultaneously with gait or standing balance in individuals with knee OA or ACL injuries. In total, fifteen studies met the inclusion criteria, nine articles examined dual-task effects on balance, and six articles reported the effects of dual-task on gait. The total number of individuals included was 230 individuals with ACL injuries, and 168 individuals with knee OA. A decline in gait and balance performance during dual-task testing is present among individuals with ACL injury and/or ACL reconstruction and knee OA. Further research is required, but dual taking assessment could potentially be used to identify individuals at risk of falling or further injury and could be used to develop targeted rehabilitation protocols. A variety of outcome measures have been used across the studies included, making comparisons difficult. The authors, therefore, recommend developing a standardized set of biomechanical balance variables.
Silibinin Upregulates CXCR4 Expression in Cultured Bone Marrow Cells (BMCs) Especially in Pulmonary Arterial Hypertension Rat Model

Previously we reported that silibinin ameliorated pulmonary arterial hypertension (PAH) in rat PAH models, possibly through the suppression of the CXCR4/SDF-1, until the point where PAH became a severe and irreversible condition. To further investigate how silibinin ameliorates PAH, we first attempted to clarify its effect on bone marrow cells (BMCs), since the CXCR4/SDF-1 axis is known to regulate stem cell migration and attachment in BM niches. Rat PAH models were established through a combination of a single subcutaneous injection of monocrotaline (MCT) and chronic hypoxic conditions (10% O2). BMCs were harvested and cultured, and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and flow cytometry (FCM) were performed to investigate whether silibinin affected CXCR4 expression. Silibinin upregulated the gene expression of stem cell related markers CXCR4, SDF-1, SCF, and c-Kit, inflammatory markers IL-6 and TNFα, mesenchymal stem cell (MSC)-related markers CD44 and CD29, and the granulocyte/monocyte-macrophage marker CD14 in cultured BM in PAH rats, but not in normal rats, except CXCR4. FCM showed that silibinin increased the CXCR4-positive cell population in a granulocyte fraction of cultured BMCs. However, immunohistochemical (IHC) staining showed no significant change in CXCR4 expression in the BM of the tibias. These results suggest that silibinin increases the expression of CXCR4 in BM, and the increased CXCR4-positive cells could be granulocytes/monocyte-macrophages.