Miracle-dz/UniFAR-FTUs huggingface dataset:
Selected isokinetic tests in knee injury prevention

Ensuing from isokinetic measurements, the conventional Hcon/Qcon ratio of muscle balance is used as an index for comparing proper relations between the values of strength of knee flexors and extensor muscle. Its abnormal values might indicate pathology of the musculotendinous complex. The aim of the study was to present the possibility of using this ratio as one of the objective identifiers enabling the assessment of knee injury risk in sports. All participants (n=48) were divided into 3 groups: group A (n=16, healthy competitors), group B (n=16, athletes with minor injuries), group C (n=16, competitors with serious injuries), depending on the degree of knee injury. All subjects performed an isokinetic test for knee extensors and flexors at angular velocities of 60°/s and 120°/s. Average peak torque (APT) value of knee flexors and extensors, and the value of Hcon/Qcon ratio was analyzed. Both values were calculated in relation to body mass (Nm/kg). Bilateral comparison of isokinetic test parameters confirmed the decrease of quadriceps muscle strength values for the injured extremity in groups B and C. Statistically significant difference was noted for Hcon/Qcon ratio between group A and C, as well as B and C. Hence, the value of conventional Hcon/Qcon ratio can be used for the prevention of sports related injuries KEY WordS: injury prevention, Hcon/Qcon ratio, Isokinetic tests, Muscle dysbalance 8. anatomic, structural, biomechanical factors. Many authors stress the importance of proper balance of antagonist muscles when participating in physical effort [16,19,21]. Muscle imbalance around a joint or body segment can lead to the lack of proper control over body movement. Knapik et al. confirmed that contralateral imbalance of hamstring group higher than 15% increases risk of injury 2,6 times [3]. Isokinetic testing provides precise evaluation of muscle strength balance. The H/Q ratio between knee extensors and flexors registered during concentric muscle contraction is one of the important parameters used for evaluation. In literature this ratio is known as the conventional Hcon/Qcon ratio and it is calculated as knee flexors peak torque divided by peak torque of knee extensor muscles. Knee extensors’ peak torque value should exceed knee flexors PT value in 3:2 ratio [28]. Hcon/Qcon ratio depends on the velocity of the movement of the tested limb, as well as on the testing position and on the evaluated group [2,29]. Many authors provide the value of 0.6 as a normative for Hcon/Qcon ratio for 60°/s which increases up to 0,8 with increased movement velocity [20,27]. Heiser et al. concOriginal Paper Biol. Sport 2010;27:47-51
Effects of saline water on health status of pregnant women in coastal regions of Bangladesh

ismail - [2010] 11.5606 Drinking water from natural sources in coastal region of Bangladesh has been contaminated by varying degrees of salinity which have detrimental effects on the health. Pregnancy itself is a crucial time for women and the salinity increases its vulnerability regarding the raising of blood pressure. The study was conducted to evaluate the effect of saline water intake on the health status of pregnant women at Barguna and Patuakhali districts, Bangladesh. Sodium (Na) concentration in urine samples was analyzed and corresponding blood pressure was taken in the diagnostic laboratory. Descriptive statistical analysis showed that Na concentration, systolic and diastolic pressure (BP) was the highest in 2nd trimester followed by 3rd trimester and 1st trimester. Water intake and urine production were the highest in 3rd trimester and increased with age. Na concentration, systolic and diastolic pressure (bp) was the highest in 3rd parity followed by 2nd parity. Water intake and urine production did not very among parities. Correlation matrix express that sodium concentration has the significant association with the age and the highly significant association with systolic and diastolic blood pressure. In Logistic Regression Model, odds ratio (OR) estimate showed that women with systolic bp? 120 had 1.109 times greater sodium concentration than with systolic blood pressure of <120 and, with diastolic bp ? 80 contain 1.064 times greater sodium concentration than with diastolic blood pressure of < 80. Asian J. Med. Biol. Res. March 2016, 2(1): 55-61 Normal 0 false false false MicrosoftInternetExplorer4 st1\:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:. 0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;}
Epileptic Seizures Related to Cerebral Venous Sinus Thrombosis: Clinicoradiological Findings and Cases of Delayed Diagnosis

Summary Objectives: We aimed to describe clinicoradiological findings and determine some causes of misdiagnosis or delay in diagnosis of patients with epileptic seizures and status epilepticus related to cerebral venous sinus thrombosis. Methods: Nine patients with seizures or status epilepticus associated with cerebral venous sinus thrombosis, admitted to the intensive care unit between November 2012 and November 2013, were included in the study. Full neurological and ophthalmological examinations, electroencephalography, computerized tomography, magnetic resonance imaging and magnetic resonance venography were performed on all of the patients. Also, previous history of neuropsychiatric disorders, initial findings of cerebral venous sinus thrombosis, specialties, where they were initially directed, and treatment interventions were recorded. Results: The main initial clinical symptom was headache in all patients. All patients had a sub-acute progression of disease. Five patients had convulsive, one had non-convulsive status epilepticus. Six patients had presenting seizures (i.e., seizures occurred before confirmation of diagnosis). The superior sagittal sinus was affected in all cases, except in patients 5 and 6. Initial diagnoses in some patients were eclampsia, dissociative disorder, subarachnoid hemorrhage, migraine, and psychotic disorder. Conclusion: Different clinical presentations of cerebral venous sinus thrombosis and the need for differential diagnosis with respect to similar neuropsychiatric diseases often cause the delay of early diagnosis and treatment of cerebral venous sinus thrombosis, and thus lead to
从“是否存在有助于预报的地震先兆”说起

是否存在有助于预报的地震先兆? 作者认为地震是以突发形式表现的构造变形,它发生前有一个由慢变快的物理过程,地震是应有先兆的. 寻找先兆除受观测仪器、测点布局、以及地震先兆与主震之间关系复杂性等的限制外,能否抓住关键时段也十分重要. 地震是一个力学过程,断层处于应力峰值强度后的亚失稳阶段时,已进入一个不可逆的变形阶段,标志着地震发生已不可避免. 因此这个阶段与地震发生有唯一性的关系.
Dichloro{2-[N-(2-hydro­xy­ethyl­ammonio­ethyl)­imino­methyl]­phenolate}zinc(II)

# 2003 International Union of Crystallography Printed in Great Britain ± all rights reserved In the title compound, [ZnCl2(C11H16N2O2)], the Zn atom is four-coordinated by one N atom and one O atom from the bidentate 2-[N-(2-hydroxyethylammonioethyl)iminomethyl]phenolate ligand and two Cl atoms in a distorted tetrahedral geometry. In the crystal, the molecules are stabilized by two NÐH O hydrogen bonds, to form columns along the a direction, which are further interconnected by OÐH Cl interactions into a three-dimensional network.
'A Model Prison for the Next 50 Years': The High-Tech, Public-Private Shimane Asahi Rehabilitation Center

The declining incarceration rate in America provides an opportunity to rethink the quality of prisons and ask: If you were told that your neighbors were newly released prisoners, what kind of institution would you want them to have served time in? One positive model of prison is a high-tech, public-private partnership prison that embraces rehabilitation, reentry and restorative justice – and that also strives to have the local community as a partner. The article reports on a visit to Shimane Asahi rehabilitation center in Japan. It provides background on the prison and Japan’s experiment with privatizing “social infrastructure. ” The article then describes the involvement of the private sector and the infusion of technology, including tracking, scanners, and automated food delivery. Next, it provides an overview of numerous educational, therapeutic, and vocational programs. Finally, it discusses how the prison has a center for community engagement and makes many efforts to utilize the resources of the local region.
Controversies in Critical Care: Glycemic Control

The pertinent perioperative issue of glucose control in known diabetics and in patients who exhibit stressinduced hyperglycemia is the focus of this chapter. With 8.3% of the population of the United States (approximately 26 million individuals) suffering from diabetes mellitus, the issue of glycemic control in the perioperative period will be encountered by every US anesthesiologist. The vast majority (more than 90%) of these patients suffer from a type of diabetes that results from inadequate production of insulin, lack of responsiveness to the insulin produced, or excessive gluconeogenesis; a combination of these factors may also be present. Evidence-based medicine (EBM) can help guide management. The evidence currently available and limitations of its application during the perioperative period will be reviewed, including the basis for the evidence supporting clinical recommendations and areas where additional research and data may be needed. The risks imposed by inadvertent hypoglycemia will be discussed and will provide a framework to address current controversies that clinicians face when attempting to optimize the care of patients with perioperative hyperglycemia based on EBM (Supplemental Digital Content 1, http://links.lww.com/ ASA/A497).
Strategies to Implement the Standard of Care/Caring Protocol in an Acute Care Oncology Hospital Setting: A Focus Group Study

The investigation examined intervention strategies used by registered nurse caring crusaders during implementation of a nursing department’s standard of care/caring protocol in a cancer hospital. The aim was to obtain increased understanding of how caring crusaders and investigators accomplished intervention fidelity during a program evaluation pilot study. An after program focus group design was implemented. Major themes consisted of context; accepting the idea of the protocol and resisting the education session in preparation for the caring protocol rollout; launching the caring protocol; getting on board with the protocol; maintaining the protocol throughout the timeline; persistence of caring crusaders; and competing standards. Additional major themes were: unanticipated project outcome; desiring recognition for performance; caring protocol: caring construct and caring activities as hidden nursing work; importance of nurse managers to the caring protocol; and reaching out to other employees about the caring protocol.
6,7-Dichloro-2,3-bis(pyridin-2-yl)quinoxaline

The title compound, C18H10Cl2N4, synthesized by the condensation reaction between 4,5-dichlorobenzene-1,2-diamine and 1,2-di(pyridin-2-yl)ethane-1,2-dione in boiling acetic acid, has a nearly planar quinoxaline moiety [maximum deviation = 0.070 (1) Å] whose mean plane makes dihedral angles of 40.51 (2) and 39.29 (3)° with the pyridine rings. Within the unit cell, there are no classical hydrogen bonds. Molecules in the structure pack with π–π stacking contacts between the quinoxaline units and nearby pyridine rings with an intercentroid distance of 3.7676 (9) Å.
Development and assessment on the eHealth Literacy Scale for college students

Objective To develop the ehealth literacy scale for college students,and assess its reliability and validity. Methods The eHealth Literacy Scale( eHEALS) was translated into Chinese version and revised after qualitative interviews and pre-investigation. A total of 1163 college students were investigated by using the scale. Results The eHEALS was included about 3 dimensions and 20 items: the acquiring ability of ehealth,the information evaluation ability of ehealth,the practical ability of ehealth. Cronbach coefficient of the 3 dimensions was between 0. 836- 0. 895,for total items was 0. 915. The factor load coefficients were between 0. 451- 0. 829. The correlation coefficient for the items in each dimension had statically significance( P 0. 05). Average score of the 1163 respondents was( 68. 03 ± 13. 04). Average score of each item was( 3. 40 ± 0. 08). Conclusion The revised ehealth literacy scale for college students( Chinese version) has acceptable constructional validity,content validity and internal consistency,which can be applied assess the ehealth literacy among college students.
Chronic infarct size after spontaneous coronary artery dissection: implications for pathophysiology and clinical management

Abstract Aims To report the extent and distribution of myocardial injury and its impact on left ventricular systolic function with cardiac magnetic resonance imaging (CMR) following spontaneous coronary artery dissection (SCAD) and to investigate predictors of myocardial injury. Methods and results One hundred and fifty-eight angiographically confirmed SCAD-survivors (98% female) were phenotyped by CMR and compared in a case–control study with 59 (97% female) healthy controls (44.5 ± 8.4 vs. 45.0 ± 9.1 years). Spontaneous coronary artery dissection presentation was with non-ST-elevation myocardial infarction in 95 (60.3%), ST-elevation myocardial infarction (STEMI) in 52 (32.7%), and cardiac arrest in 11 (6.9%). Left ventricular function in SCAD-survivors was generally well preserved with small reductions in ejection fraction (57 ± 7.2% vs. 60 ± 4.9%, P < 0.01) and increases in left ventricular dimensions (end-diastolic volume: 85 ± 14 mL/m2 vs. 80 ± 11 mL/m2, P < 0.05; end-systolic volume: 37 ± 11 mL/m2 vs. 32 ± 7 mL/m2, P <0.01) compared to healthy controls. Infarcts were small with few large infarcts (median 4.06%; range 0–30.9%) and 39% having no detectable late gadolinium enhancement (LGE). Female SCAD patients presenting with STEMI had similar sized infarcts to female Type-1 STEMI patients age <75 years. Multivariate modelling demonstrated STEMI at presentation, initial TIMI 0/1 flow, multivessel SCAD, and a Beighton score >4 were associated with larger infarcts [>10% left ventricular (LV) mass]. Conclusion The majority of patients presenting with SCAD have no or small infarctions and preserved ejection fraction. Patients presenting with STEMI, TIMI 0/1 flow, multivessel SCAD and those with features of connective tissue disorders are more likely to have larger infarcts.
LC-MS quantification of malondialdehyde-dansylhydrazine derivatives in urine and serum samples.

We developed a robust analytical method for quantification of malondialdehyde (MDA) in urine and serum samples using dansylhydrazine (DH) as a derivatizing reagent. The derivatization procedure was partially carried out using an autosampler-injection program to minimize errors associated with the low-volume addition of reagents and was optimized to yield a stable hydrazone derivative of MDA and its labeled d2-MDA analogue. The target MDA-DH derivatives were separated on an Agilent Zorbax Eclipse Plus Phenyl-Hexyl (3.0 x 100 mm, 3.5 μm) column. The mass-to-charge ratios of the target derivatives [(M + H)+ of 302 and 304 for MDA-DH and d2-MDA-DH, respectively] were analyzed in single ion monitoring mode using a single quadrupole mass spectrometer operated under positive electrospray ionization. The method limits of quantification were 5.63 nM (or 0.405 ng/mL) for urine analysis and 5.68 nM (or 0.409 ng/mL) for serum analysis. The quantification range for urine analysis was 5.63-500 nM (0.405-36.0 ng/mL) while the quantification range for serum analysis was 5.68-341 nM (0.409-24.6 ng/mL). The method showed good relative recoveries (98-103%), good accuracy (92-98%), and acceptable precisions (relative standard deviations 1.8-7.3% for inter-day precision; 1.8-6.1% for intra-day precision) as observed from the repeat analysis of quality control samples prepared at different concentrations. The method was used to measure MDA in individual urine samples (n = 287) and de-identified archived serum samples (n = 22) to assess the overall performance of the method. The results demonstrate that our method is capable of measuring urinary and serum levels of MDA, allowing its future application in epidemiologic investigations.
Single-Cell-Based Digital PCR Detection and Association of Shiga Toxin-Producing Escherichia coli Serogroups and Major Virulence Genes

Escherichia coli serogroups O157, O26, O45, O103, O111, O121, and O145, when carrying major virulence genes, the Shiga toxin genes stx1 and stx2 and the intimin gene eae, are important foodborne pathogens. They are referred to as the “top 7” Shiga toxin-producing E. coli (STEC) serogroups and were declared by the USDA as adulterants to human health. ABSTRACT Escherichia coli serogroups O157, O26, O45, O103, O111, O121, and O145, when carrying major virulence genes, the Shiga toxin genes stx1 and stx2 and the intimin gene eae, are important foodborne pathogens. They are referred to as the “top 7” Shiga toxin-producing E. coli (STEC) serogroups and were declared by the USDA as adulterants to human health. Since top 7 serogroup-positive cattle feces and ground beef can also contain nonadulterant E. coli strains, regular PCR cannot confirm whether the virulence genes are carried by adulterant or nonadulterant E. coli serogroups. Thus, traditional gold-standard STEC detection requires bacterial isolation and characterization, which are not compatible with high-throughput settings and often take a week to obtain a definitive result. In this study, we demonstrated that the partition-based multichannel digital PCR (dPCR) system can be used to detect and associate the E. coli serogroup-specific gene with major virulence genes and developed a single-cell-based dPCR approach for rapid (within 1 day) and accurate detection and confirmation of major STEC serogroups in high-throughput settings. Major virulence genes carried by each of the top 7 STEC serogroups were detected by dPCR with appropriately diluted intact bacterial cells from pure cultures, culture-spiked cattle feces, and culture-spiked ground beef. Furthermore, from 100 randomly collected, naturally shed cattle fecal samples, 3 O103 strains carrying eae and 2 O45 strains carrying stx1 were identified by this dPCR assay and verified by the traditional isolation method. This novel and rapid dPCR assay is a culture-independent, high-throughput, accurate, and sensitive method for STEC detection and confirmation.
A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice

Host genetic diversity provides a variable selection environment and physiological context for microbiota and their interaction with host physiology. Using a highly diverse mouse population, Bubier et al. identified that Odoribacter abundance influences sleep archi-tecture in a manner. The microbiome influences health and disease through complex networks of host genetics, genomics, microbes, and environment. Identifying the mechanisms of these interactions has remained challenging. Systems genetics in laboratory mice (Mus musculus) enables data-driven discovery of biological network components and mechanisms of host–microbial interactions underlying disease phenotypes. To examine the interplay among the whole host genome, transcriptome, and microbiome, we mapped QTL and correlated the abundance of cecal messenger RNA, luminal microflora, physiology, and behavior in a highly diverse Collaborative Cross breeding population. One such relationship, regulated by a variant on chromosome 7, was the association of Odoribacter (Bacteroidales) abundance and sleep phenotypes. In a test of this association in the BKS.Cg-Dock7m +/+ Leprdb/J mouse model of obesity and diabetes, known to have abnormal sleep and colonization by Odoribacter, treatment with antibiotics altered sleep in a genotype-dependent fashion. The many other relationships extracted from this study can be used to interrogate other diseases, microbes, and mechanisms.
Unravelling spiral cleavage

ABSTRACT Snails, earthworms and flatworms are remarkably different animals, but they all exhibit a very similar mode of early embryogenesis: spiral cleavage. This is one of the most widespread developmental programs in animals, probably ancestral to almost half of the animal phyla, and therefore its study is essential for understanding animal development and evolution. However, our knowledge of spiral cleavage is still in its infancy. Recent technical and conceptual advances, such as the establishment of genome editing and improved phylogenetic resolution, are paving the way for a fresher and deeper look into this fascinating early cleavage mode. Summary: Spiral cleavage is one of the most under-investigated, yet widespread developmental strategies in animals: a powerful system for exploring fundamental questions in evolutionary developmental biology.
Emerging Tick-Borne Diseases

Increases in tick-borne disease prevalence and transmission are important public health issues. Efforts to control these emerging diseases are frustrated by the struggle to control tick populations and to detect and treat infections caused by the pathogens that they transmit. This review covers tick-borne infectious diseases of nonrickettsial bacterial, parasitic, and viral origins. SUMMARY Increases in tick-borne disease prevalence and transmission are important public health issues. Efforts to control these emerging diseases are frustrated by the struggle to control tick populations and to detect and treat infections caused by the pathogens that they transmit. This review covers tick-borne infectious diseases of nonrickettsial bacterial, parasitic, and viral origins. While tick surveillance and tracking inform our understanding of the importance of the spread and ecology of ticks and help identify areas of risk for disease transmission, the vectors are not the focus of this document. Here, we emphasize the most significant pathogens that infect humans as well as the epidemiology, clinical features, diagnosis, and treatment of diseases that they cause. Although detection via molecular or immunological methods has improved, tick-borne diseases continue to remain underdiagnosed, making the scope of the problem difficult to assess. Our current understanding of the incidence of tick-borne diseases is discussed in this review. An awareness of the diseases that can be transmitted by ticks in specific locations is key to detection and selection of appropriate treatment. As tick-transmitted pathogens are discovered and emerge in new geographic regions, our ability to detect, describe, and understand the growing public health threat must also grow to meet the challenge.
Complete Coding Sequence of Western Equine Encephalitis Virus Strain Fleming, Isolated from a Human Case

We sequenced the complete coding genome of the western equine encephalitis virus (WEEV) strain Fleming. This strain was originally isolated in 1938 from a human WEEV case. ABSTRACT We sequenced the complete coding genome of the western equine encephalitis virus (WEEV) strain Fleming. This strain was originally isolated in 1938 from a human WEEV case.