Miracle-dz/UniFAR-FTUs huggingface dataset:
Some aspect of potency of enzymes located in epithelium of proximal tubules as sifteted test for detecting early renal damage in the patients with untreated rheumatoid arthritis treat with most used drugs

Aim: To estimate the effect of initial therapy with Paracetamol and Ketoprofen on glomerular and tubular integrity in patients with Rheumatoid arthritis (RA), to quantify toxicity of these drugs through measurements of the enzyme excretion that correlates with the damage degree on the tubular epithelium. Microalbuminuria is used as marker for glomerular damage, and the urinary excretion of N-Acetyl--D-glucozaminidase (NAG) as an indicator of proximal tubular damage. To determine if there is a change in the clinical indicators od renal function (serum urea and creatinine, urine urea and creatinine, glomerular filtration rate - GFR) in the course of disease and if that change correlates with the dynamics of the quantity of excreted enzymes in urine, reactants of the acute pfase and index of disease activity (DAS28). Methods: Using the colorimetric method for determination of NAG, as well as immunoturbidimetric immunoturbidimetric assay for detection of microalbuminuria, we examined samples of 70 participants (35 RA pts treated only with Paracetamol, 35 RA pts treated with Ketoprofen), followed up in five time intervals in the course of 24 weeks. Rheumatoid factor (RF) is determined with the agglutination test (Lateks RF test) in the same participants. Results : there is a weak correlation between NAG and microalbuminuria (r=0.16) in the group of patients treated with Paracetamol, while in the group treated with Ketoprofen there is moderate correlation (r=0.28). NAG enzymuria in range, in number of examined patients and in time of appearance is greater and appears earlier in the group with Ketoprofen compared with the group of Paracetamol. Conclusions: Ketoprofen is more potent NAG inductor and triggers greater tubular enzymuria than Parcetamol.
Greenhouse gas emissions from the energy crop oilseed rape ( Brassica napus ); the role of photosynthetically active radiation in diurnal N 2 O ﬂux variation

Oilseed rape (OSR, Brassica napus L.) is an important feedstock for biodiesel; hence, carbon dioxide (CO 2 ), methane (CH 4 ) and particularly fertilizer-derived nitrous oxide (N 2 O) emissions during cultivation must be quantiﬁed to assess putative greenhouse gas (GHG) savings, thus creating an urgent and increasing need for such data. Substrates of nitriﬁcation [ammonium (NH 4 )] and denitriﬁcation [nitrate (NO 3 )], the predominant N 2 O production pathways, were supplied separately and in combination to OSR in a UK ﬁeld trial aiming to: (i) produce an accurate GHG budget of fertilizer application; (ii) characterize short- to medium-term variation in GHG ﬂuxes; (iii) establish the processes driving N 2 O emission. Three treatments were applied twice, 1 week apart: ammonium nitrate fertilizer (NH 4 NO 3 , 69 kg-N ha (cid:1) 1 ) mimicking the farm management, ammonium chloride (NH 4 Cl, 34.4 kg-N ha (cid:1) 1 ) and sodium nitrate (NaNO 3 , 34.6 kg-N ha (cid:1) 1 ). We deployed SkyLine2D for the very ﬁrst time, a novel automated chamber system to measure CO 2, CH 4 and N 2 O ﬂuxes at unprecedented high temporal and spatial resolution from OSR. During 3 weeks following the fertilizer application, CH 4 ﬂuxes were negligible, but all treatments were a net sink for CO 2 (ca . 100 g CO 2 m (cid:1) 2 ). Cumulative N 2 O emissions (ca . 120 g CO 2 -eq m (cid:1) 2 ) from NH 4 NO 3 were signiﬁcantly greater ( P < 0.04) than from NaNO 3 (ca . 80 g CO 2 -eq m (cid:1) 2 ), but did not differ from NH 4 Cl (ca . 100 g CO 2 -eq m (cid:1) 2 ) and reduced the carbon sink of photosynthesis so that OSR was a net GHG source in the fertilizer treatment. Diurnal variation in N 2 O emissions, peaking in the afternoon, was more strongly associated with photosynthetically active radiation (PAR) than temperature. This suggests that the supply of carbon (C) from photosynthate may have been the key driver of the observed diurnal pattern in N 2 O emission and thus should be considered in future process-based models of GHG emissions.
Growing Complex Software Systems A Formal Argument for Piecemeal Growth in Software Engineering

– With piecemeal growth, complex systems are grown in a series of small steps rather than pieced together in one large lump. Although there are many specific examples (from agile methods) of piecemeal growth in software engineering; we argue that prior art has yet to produce general theoretical argument for building complex software systems this way. In this research, we propose a formal, theoretical argument for the general applicability of piecemeal growth to software engineering. As part of our argument, we infer both the requisites for piecemeal growth and some surprising connections between piecemeal growth and existing disciplines within software engineering.
Identiﬁcation of Postentry Restrictions to Mason-Pﬁzer Monkey Virus Infection in New World Monkey Cells (cid:1)

TRIM5 (cid:1) has been shown to be a major postentry determinant of the host range for gammaretroviruses and lentiviruses and, more recently, spumaviruses. However, the restrictive potential of TRIM5 (cid:1) against other retroviruses has been largely unexplored. We sought to determine whether or not Mason-Pﬁzer monkey virus (M-PMV), a prototype betaretrovirus isolated from rhesus macaques, was sensitive to restriction by TRIM5 (cid:1) . Cell lines from both Old World and New World primate species were screened for their susceptibility to infection by vesicular stomatitis virus G protein pseudotyped M-PMV. All of the cell lines tested that were established from Old World primates were found to be susceptible to M-PMV infection. However, ﬁbroblasts established from three New World monkey species speciﬁcally resisted infection by this virus. Exogenously expressing TRIM5 (cid:1) from either tamarin or squirrel monkeys in permissive cell lines resulted in a block to M-PMV infection. Restriction in the resistant cell line of spider monkey origin was determined to occur at a postentry stage. However, spider monkey TRIM5 (cid:1) expression in permissive cells failed to restrict M-PMV infection, and interference with endogenous TRIM5 (cid:1) in the spider monkey ﬁbroblasts failed to relieve the block to infectivity. Our results demonstrate that TRIM5 (cid:1) speciﬁcity extends to betaretroviruses and suggest that New World monkeys have evolved additional mechanisms to restrict the infection of at least one primate betaretrovirus. with PBS containing 4% Quantitative real-time PCR analysis of reverse transcription products. Taq- Man primer/probe sets were developed to selectively amplify regions in either the strong-stop DNA reverse transcription (RT) product or the gag portion of the full-length RT product. The primers “ssDNA F” (5 (cid:8) -CCACCATTAAATGAG ACTTGATCAG-3 (cid:8) ), “ssDNA R” (5 (cid:8) -GGAGGGAGTGGGAATTGAAG-3 (cid:8) ), and “ssDNA probe” (5 (cid:8) -ACACTGTCTTGTCTCCATTTCTTGTGTCTCTTG-3 (cid:8) ) were used to quantify the strong-stop DNA product. The primers “gag F” (5 (cid:8) -GCTTGGAAGATGAGGCAGCGAAAT-3 (cid:8) ), “gag R” (5 (cid:8) -ATTACAGTG GGTGCGGAAGGAGTA-3 (cid:8) ), and “gag probe” (5 (cid:8) -TAATCCCGATTGGCCT CCCTTCCTAA-3 (cid:8) ) were used to quantify full-length RT products. The strong-stop DNA probe was tagged at the 5 (cid:8) end with 6-carboxyﬂuorescein,
The synergy of combined free nitrous acid and Fenton technology in enhancing anaerobic digestion of real sewage waste activated sludge CURRENT STATUS: POSTED

Recently, free nitrous acid (FNA) pre-treatment of sewage waste activated sludge has been introduced as an economically attractive and environmentally friendly technique for enhancing methane production from the anaerobic digestion process. Fenton pre-treatment of sewage sludge, as an advanced oxidation process, has also been introduced as a powerful technique for methane improvement in a couple of studies. This study, for the first time, investigates the synergy of combined FNA and Fenton pre-treatment technologies in enhancing the methane production from the anaerobic digestion process and reducing waste sludge to be disposed of. Actual secondary waste activated sludge in laboratory-scale batch reactors was used to assess the synergistic effect of the pre-treatments. The mechanisms behind the methane enhancement were also put into perspective by measuring different microbial enzymes activity and solubilisation of organic matter. Result This study revealed that the combined pre-treatments release organic matter into the soluble phase significantly more than the bioreactors pre-treated with individual FNA and Fenton. For understanding the influence of pre-treatments on solubilisation of organic matter, soluble protein, soluble polysaccharide and soluble chemical oxygen demand (SCOD) were measured before and after the treatments and it was shown that they respectively increased by 973%, 33% and 353% after the treatments. Protease and cellulose activity, as the key constituents of the microbial community presenting in activated sludge, decreased considerably within the combined pre-treatments (42% and 32% respectively) and methane production enhanced by 43-69%. Furthermore, total solids and volatile solids destruction improved by 26% and 24% at the end of anaerobic digestion, which can reduce transport costs of sludge and improve the quality of sludge for application in farms and forests. The results obtained from the experiments corroborate the synergic effect of the combined FNA and Fenton pre-treatment technologies in degrading the organic and microbial constituents in waste
Conceptualising the manure distribution system by means of MAIA

To study the potential for manure-based energy production, we decided to explore possible system behaviours by means of an agent-based model. In order to develop this agent-based model we propose the MAIA framework as this methodology allows the system to be adequately captured for agent-based social simulation. The MAIA framework constitutes a meta-model for Modelling Agent systems based on Institutional Analysis and is based on the Institutional Analysis Development (IAD) framework, which applies an institutional perspective on social system concepts. In order to make use of the MAIA framework a good understanding of the system is required. As a result, we propose to use an integrated system perspective with respect to the system analysis. Conceptualisation of the manure distribution system by means of MAIA results in an enhanced documentation that allows for a feasible translation of the system into computer code.
Systems of Markov State Kinetic Models Based on Routh-Hurwitz Criterion

In computational neuroscience, receptors, channels and more generally signaling pathways are often modeled with Markov state models to represent biochemical reactions, which are then implemented with bilinear equations. One of the goals of these models, once calibrated with experimental results is to predict the dynamics of the biological system they represent in response to molecular perturbations and therefore facilitate and enhance the success rate of drug discovery and development. To model receptors under both pathological and physiological conditions, modelers usually modify the ligand association and dissociation parameters in the kinetic model during the optimization phase of model development. However, some parameter values may lead to unstable models, (cid:80)(cid:68)(cid:78)(cid:76)(cid:81)(cid:74)(cid:3)(cid:70)(cid:68)(cid:79)(cid:76)(cid:69)(cid:85)(cid:68)(cid:87)(cid:76)(cid:82)(cid:81)(cid:3)(cid:89)(cid:72)(cid:85)(cid:92)(cid:3)(cid:71)(cid:76)(cid:73)(cid:191)(cid:70)(cid:88)(cid:79)(cid:87)(cid:15)(cid:3)(cid:87)(cid:76)(cid:80)(cid:72)(cid:16)(cid:70)(cid:82)(cid:81)(cid:86)(cid:88)(cid:80)(cid:76)(cid:81)(cid:74)(cid:3)(cid:68)(cid:81)(cid:71)(cid:3)(cid:76)(cid:81)(cid:72)(cid:73)(cid:191)(cid:70)(cid:76)(cid:72)(cid:81)(cid:87)(cid:3)(cid:69)(cid:72)(cid:73)(cid:82)(cid:85)(cid:72)(cid:3)(cid:83)(cid:72)(cid:85)(cid:73)(cid:82)(cid:85)(cid:80)(cid:76)(cid:81)(cid:74)(cid:3)(cid:83)(cid:85)(cid:72)(cid:71)(cid:76)(cid:70)(cid:87)(cid:76)(cid:89)(cid:72)(cid:3)(cid:76)(cid:81)(cid:3)(cid:86)(cid:76)(cid:79)(cid:76)(cid:70)(cid:82)(cid:3)(cid:86)(cid:87)(cid:88)(cid:71)(cid:76)(cid:72)(cid:86)(cid:17)(cid:3)(cid:44)(cid:81)(cid:3)(cid:82)(cid:85)(cid:71)(cid:72)(cid:85)(cid:3)
OPTIMIZATION OF BINARY AND MULTI-VALUED DIGITAL CIRCUITS USING MVSIS AND AIG REWRITING (ABC)

– Benchmark designs are the basis for the performance evaluation of today’s EDA tools for assisting the synthesis of an integrated circuit. The most commonly employed method to verify the competitiveness of a new tool consists of applying this tool to a set of benchmark designs in a given experimental setting. The experimental results are then compared to those obtained by applying a comparable state-of-the-art tool to the same set of designs. Berkeley Logic Interchange Format (BLIF) is used to represent combinational and sequential logic networks used in academic logic synthesis and verification tools. This paper is concerned with focusing the comparison of AIG rewriting in ABC with logic synthesis in MVSIS on MCNC benchmark. We have also performed Node reduction with MVSIS (script.rugged) and ABC (resyn2)
A spectral method for integral formulations of medium-frequency scattering problems

A fast method for the computation of layer potentials that arise in acoustic scattering is introduced. The principal idea is to split the singular kernel into a smooth and a local part. The potential due to the smooth part is computed efficiently using non-equispaced FFTs, the potential due to the local part is expanded as a series in the mollification parameter. The complexity of the approach is shown to be $O(n + \kappa^3 \log \kappa)$, where $n$ is the number of degrees of freedom in the discretization and $\kappa$ is the wave number. The constant factor in this asymptotic estimate is small since no singular surface integrals must be computed. Therefore the method is particularly efficient for medium-sized scatterers (50-100 wavelengths) that may have complicated geometry
Assembly and Intracellular Targeting of the (cid:98)(cid:103) Subunits of Heterotrimeric G Proteins

The assembly in living cells of heterotrimeric guanine nucleotide binding proteins from their constit-uent (cid:97) , (cid:98) , and (cid:103) subunits is a complex process, com-pounded by the multiplicity of the genes that encode them, and the diversity of receptors and effectors with which they interact. Monoclonal anti- (cid:98) antibodies (ARC5 and ARC9), raised against immunoaffinity purified (cid:98)(cid:103) complexes, recognize (cid:98) subunits when not associated with (cid:103) and can thus be used to monitor assembly of (cid:98)(cid:103) complexes. Complex formation starts immediately after synthesis and is complete within 30 min. Assembly occurs predominantly in the cytosol, and association of (cid:98)(cid:103) complexes with the plasma membrane fraction starts between 15–30 min of chase. Three pools of (cid:98) subunits can be distinguished based on their association with (cid:103) subunits, their localization, and their detergent solubility. Association of (cid:98) and (cid:97) subunits with detergent-insoluble domains occurs within 1 min of chase, and increases to reach a plateau of near complete detergent resistance within 30 min of chase. Brefeldin A treatment does not interfere with delivery of (cid:98)(cid:103) subunits to detergent-insoluble domains, suggest-ing that assembly of G protein subunits with their receptors occurs distally from the BFA-imposed block of intracellular membrane trafficking and
The Eﬀect of Synbiotic as an Adjuvant Therapy to Fluoxetine in Moderate Depression: A Randomized Multicenter Trial

Background: Depression is a serious and burdensome disorder in modern societies, with lifetime prevalence of about 16%. Dis-turbedimmuneresponsesinthegutandimmune-privilegedsitesincludingthecentralnervoussystemmightoccursubsequentto dysbiosisof gutmicrobiome. Inthisstudyweaimedatassessingtheeﬃcacyof 6weekssynbioticsupplementationinthetreatment of moderate depression in a double-blind, placebo-controlled, multi-center, and randomized trial. Methods: A total of 40 adult outpatients, who met the diagnostic and statistical manual of mental disorders ﬁfth edition for moderate depression, were recruited based on the structured interview for DSMV. Recruited patients had a Hamilton rating scale for depression (HAM-D) score of 17 to 23 at baseline. All patients received ﬂuoxetine (20 mg/d) for 4 weeks. Then, either a synbiotic capsule (plus ﬂuoxetine) or placebo (plus ﬂuoxetine) was added to the therapy for 6 weeks. Results: Themeanageof theparticipantsinthesynbiotictreatedgroupwas34.45yearsanditwas35. 50yearsintheplacebogroup. Following the adjustment of ANCOVA models for gender, age, and BMI at baseline, there was a greater reduction in HAM-D score in synbiotictreatedpatients(Mean ± SD=-19.25 ± 1.71)comparedtoplacebotakinggroup(Mean ± SD=-17.75 ± 2.05;P=0.024). Atthe endof the10thweekof theinterventionandafterapplyingANCOVAadjustedforthementionedvariablesaswellasbaselineHAM-D score, it was found that the synbiotic group had a signiﬁcantly decreased HAM-D score compared to the placebo (3.65 vs. 4.80, P = 0.013). Conclusions: The results of the current study revealed the eﬃcacy of synbiotic as an adjuvant therapy in moderate depression.
Presenting Evocative Design as a Method for Divergent Thought for Interaction Design

: This paper describes evocative design as a design method for engaging in problem setting in interaction design. Evocative design ideas play on designers’ attempts to uncover assumptions in a problem space by creating uncommon design ideas and encourage new ways of thinking about design problems. We feel this is a beneficial practice since such designs expose innovations that typical user-centered approaches may not. We also provide a set of commitments for identifying potentially valuable designs as a design community based on designers' intentions. Commitments keep design ideas generated through the evocative design method grounded and connected with the client, design community, and society underlying a given problem space. The paper will not describe a systematic procedure for engaging in evocative design, but rather will make the argument for its efficacy as design method for interaction design.
Materiality in The Context of Sustainability

Materiality is a hotly debated topic, not only at the financial level but also at the sustainability level. Until a few years ago, multiple bodies (d standards regarding reporting inherent to sustainability. Currently, we are seeing a consolidation of various bodies into one Board and the emergence of very close collaborations between bodies giving these standards. This reduces the definitions of materiality, which were marked by even considerable differences in the past. In the following pages, we will highlight the central bodies that (standards concerning sustainability and the definition of materiality contained in these standards alla sostenibilitàCurrently, there is a consolidation of several bodies into a single OA body, with very close cooperation between bodies issuing standards. This reduces the definitions of materiality, which in the past, were marked by differences even known i. On the following pages, we will highlight the main bodies issuing standards concerning sustainability and is the definition of materiality contained in these standards.
Edinburgh Research Explorer Meaning Representation for Paraphrase Detection

Abstract Meaning Representation (AMR) parsing aims at abstracting away from the syntactic realization of a sentence, and denoting only its meaning in a canonical form. As such, it is ideal for paraphrase detection, a problem in which one is required to specify whether two sentences have the same meaning. We show that na ¨ ıve use of AMR in paraphrase detection is not necessarily useful, and turn to describe a technique based on latent semantic analysis in combination with AMR parsing that signiﬁcantly advances state-of-the-art results in paraphrase detection for the Microsoft Research Paraphrase Corpus. Our best results in the transductive setting are 86.6% for accuracy and 90.0% for F 1 measure.
Visualization and bibliometric analysis on the research of financial well-being

Financial well-being using a bibliometrics analytical approach to analyze the networks, clusters, and trends of scientific production is studied. This research uses a systematic literature review process, which is a step-by-step process-driven methodology, to find 327 articles published between 1978 and 2021 on the subject of financial well-being. This paper applies the bibliometrics method to investigate the research trends in the study of financial well-being, specifically analyzing the quality of the research by the citation status and the mutual influence of these articles. The results of the study provide an overview of citation trends on financial well-being such as the most cited papers and the network of these papers, the keyword distribution, the co-authorship status, bibliographic coupling analysis, and the most influential journals. This study tries to determine the trends and development of financial well-being research. This can help researchers attain a comprehensive understanding of this field and can be a reference for the application of financial well-being visualization approaches.
a novel and Src dual inhibitor, induces apoptosis in prostate cancer cells and overcomes resistance to Src inhibitors.

Etk Abstract Etk is a non-receptor tyrosine kinase, which provides a strong survival signal in human prostate cancer cells. Src, another tyrosine kinase that cross-activates with Etk, has been shown to play an important role in prostate cancer metastasis. Herein, we discovered a new class of Etk inhibitors. Within those inhibitors, CTA095 was identified as a potent Etk and Src dual inhibitor. CTA095 was found to induce autophagy as well as apoptosis in human prostate cancer cells. In addition, CTA095 inhibited HUVEC cell tube formation and ‘‘wound healing’’ of human prostate cancer cells, implying its role in inhibition of angiogenesis and metastasis of human prostate cancer. More interestingly, CTA095 could overcome Src inhibitor resistance in prostate cancer cells. It induces apoptosis in Src inhibitor resistant prostate cancer cells, likely through a mechanism of down regulation of Myc and BCL2. This finding indicates that simultaneously targeting Etk and Src could be a promising approach to overcome drug resistance in prostate cancer.
P OSITION B IAS IN B EST-WORST S CALING S URVEYS : A C ASE S TUDY ON T RUST IN I NSTITUTIONS

This paper investigates the effect of items’ physical position in the best-worst scaling technique. Although the best-worst scaling technique has been widely used in many ﬁelds, the literature has largely overlooked the phenomenon of consumers’ adoption of processing strategies while making their best-worst choices. We examine this issue in the context of consumers’ trust in institutions to provide information about a new food technology, nanotechnology, and its use in food processing. Our results show that approximately half of the consumers used position as a schematic cue when making choices. We ﬁnd the position bias was particularly strong when consumers chose their most trustworthy institution compared to their least trustworthy institution. In light of our ﬁndings, we recommend that researchers in the ﬁeld be aware of the possibility of position bias when designing best-worst scaling surveys. We also encourage researchers who have already collected best-worst data to investigate whether their data shows such heuristics.