Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular Analysis of P53 Codon 72 Polymorphism and Risk of Cervical Carcinoma among Women in Southwest of the Republic of Congo: A Case-Control Study

1Laboratoire de Virologie, Microbiologie et Qualite/ETB, Faculty des Sciences et Techniques, University Hassan II de Casablanca B.P. 146, Mohammedia 20650, Marco 2Laboratoire d’Agroalimentaire et Sante, Department de Biology Applique, Faculty des Sciences et Techniques, University Hassan 1er Set tat B.P. 577 Set tat, Marco 3Laboratoire d ’Analyses Medicals et Morphologiques, Hospital General de Loandjili, B.P. 8122, Pointe-Noire, Congo 4Departement de biology, Faculty des sciences de la Santé, University Marien NGOUABI B.P. 69 Brazzaville, Congo
Numerical approximation of statistical solutions of incompressible flow

We present a finite difference-(Multi-level) Monte Carlo algorithm to efficiently compute statistical solutions of the two dimensional Navier-Stokes equations, with periodic boundary conditions and for arbitrarily high Reynolds number. We propose a reformulation of statistical solutions in the vorticity-stream function form. The vorticity-stream function formulation is discretized with a finite difference scheme. We obtain a convergence rate error estimate for this approximation. We also prove convergence and complexity estimates, for the (Multi-level) Monte Carlo finite-difference algorithm to compute statistical solutions. Numerical experiments illustrating the validity of our estimates are presented. They show that the Multi-level Monte Carlo algorithm significantly accelerates the computation of statistical solutions, even for very high Reynolds numbers.
International Journal of Human Sciences / Uluslararası İnsan Bilimleri Dergisi

Since the dawn of social media, sports performance professionals have had the ability to share ideas and display training methodologies to anyone across the globe. Research problem/aim: The problem with this connectedness is much of this information is baseless. Coaches, athletes, and parents are too often misinformed, confused, and misled by fad exercise programs and gimmicks that can put their athletes under too much stress (physical and emotional) too fast, putting them at risk of injury. Findings: In order to be successful on the sporting field, athletes need to be able to make it to the playing field first. Sports performance specialists need to focus on long term development, not just pushing their athletes to the limit. Athletes need a structured training progression that builds a solid foundation of strength, endurance, and coordination to give them the tools to be successful in the weight room before placing them under a loaded bar or implementing advanced training techniques. With athletes at any level, high school, collegiate, or professional, even the most talented athletes on the field may not necessarily have a very strong background in the weight room. Conclusion: A systematic pattern of athletic development would allow adaptation in fundamental movement patterns and develops requisite physical qualities, and allow the athletes to advance safely and effectively.
Developing a stable isotope approach to trace the sources and metabolism of phosphorus in freshwaters

The oxygen isotope ratio of dissolved inorganic phosphate (δ18Op) represents a novel and potentially powerful stable isotope tracer for biogeochemical research. Analysis of δ18Op may offer new insights into the relative importance of different sources of phosphorus within natural ecosystems. Due to the isotope fractionations that occur alongside metabolism of phosphorus-containing compounds, δ18Op could also be used to better understand the intracellular and extracellular reaction mechanisms that control phosphorus cycling. In this thesis, new methods were developed and tested for the extraction of dissolved inorganic phosphate (Pi) from freshwaters and its isolation from other oxygen-containing compounds, including nitrate, sulfate and dissolved organic matter. Excluding contaminant sources of oxygen during δ18Op analysis is a critical analytical challenge that has constrained δ18Op research in freshwaters to date. These new methods were evaluated against existing protocols for analysis of δ18Op. While the protocol developed in this thesis exhibited greater accuracy and precision for freshwater matrices compared to the traditional approach reported by McLaughlin et al. (2004), further development work is required to increase the accuracy of this protocol compared to that reported by Gooddy et al. (2016). Through the application of δ18Op within two exemplar freshwater ecosystems in this thesis, the in-stream fate of Pi derived from the effluent of a wastewater treatment plant and from groundwater discharge was examined. Within both ecosystems, δ18Op revealed the occurrence of metabolic processes that influenced the in-stream fate of P yet were masked in the hydrochemical data. In addition, the data reported here increase the worldwide groundwater δ18Op dataset nearly threefold. These groundwater data highlight the important potential differences in δ18Op due to bedrock geology, alongside the potential to use δ18Op to better understand the importance of groundwater-derived P following discharge to surface water ecosystems. -Gooddy, D.C., D.J. Lapworth, S.A. Bennett, T.H. E. Heaton, P.J. Williams & B.W. J. Surridge. 2016. A multi-stable isotope framework to understand eutrophication in aquatic ecosystems. Water Research. 88 , 623 -McLaughlin, K. , S. Silva, C. Kendall, H. Stuart-Williams & A. Paytan. 2004. A precise method for the analysis of δ18O of dissolved inorganic phosphate in seawater. Limnology and Oceanography: Methods. 2 , 202
La improcedencia de estandarizar el trabajo docente: Un análisis desde Chile

Cada vez, más países implementan políticas de rendición de cuentas y estandarización como solución a los problemas de equidad y calidad educativa. Este artículo examina la pertinencia de diseñar el trabajo docente con base en diferentes mecanismos de estandarización. Para ello, se utiliza la propuesta de Henry Mintzberg, una teoría de comportamiento organizacional que plantea mecanismos de coordinación referidos a distintas formas de organizar el trabajo según sus características y objetivos. Con este marco teórico se analiza el modelo escolar chileno, que sobresale por el uso de la estandarización para regular procesos y resultados. El análisis confirma la hegemonía de estos mecanismos de estandarización mediante distintos dispositivos evaluativos y prescriptivos de la política escolar, así como también permite afirmar su improcedencia por efecto de diversas externalidades negativas empíricamente sustentadas. A partir de este examen se discute la pertinencia de otros mecanismos de coordinación para el diseño de la política escolar, proponiéndose un modelo que prevalezca en formas regulatorias ligadas con el desarrollo de habilidades situadas, el trabajo colaborativo y la formación en valores socioeducativos.
Visual outcome and optical quality after implantation of zonal refractive multifocal and extended-range-of-vision IOLs: a prospective comparison

Methods: The study included patients who had cataract surgery and were implanted with a Tecnis Symfony Extended Range of Vision (EROV) IOL (ZXR00), a zonal refractive multifocal IOL (Lentis Comfort LS-313 MF15), or a monofocal IOL (Lentis L-313). Postoperative examinations took place at 1 week, 1 month, and 3 months and included visual acuity at far, intermediate, and near distances, defocus curves, contrast sensitivity, wavefront aberrations, and modulation transfer function (MTF). Patients completed the Visual Function Index questionnaire (VF-14), the Quality of Vision questionnaire (QoV), and a visual quality self-evaluation.
Induction of the cytochrome P450 by 2-tridecanone in Helicoverpa armigera

The induction of the cytochrome P450 (cyt-P450) by 2-tridecanone in cotton bollworm,Helicoverpa armigera% (Hubner) larvae was investigated. By mixing 2-tridecanone at low dosages (0.005%～0.01%) for three generations, the content and difference spectra of cyt-P450 interacted with CO and ligands, including pyridine,n-butanol,aniline and cyclohexane, were investigated with cyt-P450 preparation from midgut and fat body of the sixth instar cotton bollworm. The maximal absorption of cyt-P450 interacted with CO was observed around 449 nm for midgut preparation and 450.70 nm for fat body preparation respectively based on 15 to 40 scans in the induction colony, and 449.22 nm for midgut preparation and 449.20 nm for fat body preparation respectively in the control colony. Besides an absorption peak around 449 nm, there were in turn three other absorption peaks around 414, 415, 419 nm in midgut cytochrome P450, thereafter the absorption disappeared, and there was a weak absorption at 420 nm at the thirty-first scan. In the absorption spectrum of cyt-P450 bound with n-butanol, two peaks and two troughs occurred for midgut preparation and one peak and one trough in fat body preparation. The maximal absorption peaks were at 380.10 nm, 415.02 nm for midgut preparation and 416.61 nm for fat body preparation, while the absorption troughs were at 395.02 nm, 423.24 nm for midgut preparation and 424.91 nm for fat body preparation. Characteristic type Ⅱ spectrum occurred with cyt-P450 bound with pyridine, for midgut preparation with a maximal absorption at 425.57 nm and a trough at 395.48 nm; for fat body preparation with a maximal absorption at 422.19 nm and a trough at 415.90 nm. Uncharacteristic type Ⅰ spectrum occurred with cyt-P450 bound with cyclohexane, for midgut preparation with maximal absorption peaks at 378.00 nm and 448.12 nm; for fat body preparation with the maximal absorption peaks at 380.00 nm and 434.04 nm. Type Ⅱ spectrum occurred with cyt-P450 bound with aniline, for midgut preparation with a maximal absorption at 443.30 nm and a trough at 402.30 nm; for fat body preparation with a maximal absorption at 428.92 nm and a trough at 401.00 nm.
Design and Synthesis of Novel NSAIDs Class Acting as Anticancer Agents

Several effective anticancer therapeutic drugs containing coumarin nucleus. Thus, some coumarin derivatives 3-22 were prepared. The structures of these compounds established on the basis of spectral data as IR, 1 HNMR, 13 CNMR and MS. Moreover, the optimization geometries for compounds 3-13,15,17a,18a,19-22 were discussed using PM3 base set. The molecular docking simulations into the active site of COX-2 were performed, and showed that, some compounds 7,8, 11,13, and 20 are suitable inhibitor against COX-2, and can used as anti-cancer drugs. The compounds 7,8, 11,13 and 20 were evaluated on 50µg dose, against Ehrlich solid carcinoma (EAC) tumor model in Swiss albino mice . The activity was assessed using survival time and average increase in body weight, and showed that, these compounds are effective in reducing solid tumor mass EAC cells, and 20 showed highest potency. In silico, The ADMET profiles showed that, these 7,8, 11,13 and 20 compounds are good oral bioavailability, and are CNS active agents without marked health effects observed for rodent toxicity. abs. to give compound %; IR cm 3323 cm 2961cm (CH-ali.), 1767 cm amide; 1 H MHz, Chloroform) 9.24,8.32 (s,2H,NH 7.62-6.55 (m,9H,CH-arm.), 6.54 (s,1H,NH-arm.), 4.81 (m,1H,CH-phe.), 3.23 (s,2H,CH2-ali.), 2.84 (d, 2H,CH 2 -Phe), 2.27,1.99( s,6H,2CH COCH MS (m/z,%) 465 (1.61%) Anal. /Calcd.for C 24 H 23 N 3 (61.91%), H (4.94%), N (9.02%). Found: C (61.93); H N, stirred with compound ( 5 ) for 6hrs. Then the reaction mixture poured onto ice path. The solid obtained was recrystallized from ethanol to give compound ( 20 ) as white crystal; Yield:(85 %); Rf 0.86 (CH M.P.=238-40°C.; by different spectral data (IR, 1 HNMR). The antitumor activity of tested compounds ( 7,8, 11,13,19b and 20 ) were examined in vitro against Ehrlich solid carcinoma (EAC) tumor model in Swiss albino mice on dose 50µg , using the following parameters, body weight of animals, tumor volume, and tumor growth inhibition. The data showed that, introducing thiourea free acid fragment 20 enhancements antitumor activity than reference drug (DOX). The optimization geometries for compounds containing L-Phe. , showed that, the L- isomers are most stable form for isolated compounds 3-13,15,17a,18a,19-22 . The molecular docking simulations into the active site of COX-2 showed that, some
Efficacy and Safety of Sea Salt-Derived Physiological Saline Nasal Spray as Add-On Therapy in Patients with Acute Upper Respiratory Infection: A Multicenter Retrospective Cohort Study

Background The purpose of this study was to assess the effects of seawater on nasal congestion and runny nose symptoms in adults with an acute upper respiratory infection (URI). Material/Methods This was a multicenter retrospective cohort trial of patients with acute URI and symptoms of nasal congestion and runny nose. The patients were assigned to 2 groups and were administered regular non-drug supportive treatment or supportive treatment with nasal irrigation with sea salt-derived physiological saline. The primary efficacy endpoint was the effective rate (percentage of patients with ≥30% symptom score reduction from baseline for nasal congestion and runny nose). Results In total, 144 patients were enrolled, including 72 in each group, and 143 patients completed the study. Both groups had similar demographics and vital signs. The effective rates for nasal congestion and runny nose were significantly increased in the seawater group compared with patients in the control group (87.3% vs 59.7% for nasal congestion; 85.9% vs 61.1% for runny nose; both P<0.001). In addition, the 2 groups showed markedly different degrees of patient symptom score improvement in sleep quality and appetite (both P<0.01), but not in cough and fatigue (both P>0.05). There were no adverse events in either group. Conclusions The sea salt-derived physiological saline nasal spray device satisfactorily improved nasal congestion, runny nose, sleep quality, and appetite in adults with URI, with no adverse effects.
AGROBIODIVERSITY FOR IMPROVING NUTRITION, HEALTH AND LIFE QUALITY 2017

The aim of the work was to investigate the effect of short-term cold stress on the growth, antioxidant activity and flavonoids synthesis in the Artemisia tilesii “hairy“ root cultures. The effect of low temperature was studied by roots cultivating during the first 1, 2 and 5 days at +10 °C, then the plants were grown at +24 °C The total flavonoids content in Rutin equivalent was determined spectrophotometrically using alumunium chloride assay. Antioxidant activity of ethanolic extracts was studied using the DPPH method. The root lines differed in sensitivity to short-term temperature decrease up to +10 °C. Stress factor action resulted in a reduction of mass increment in 1.7–3 times. At the same time, two lines were found to be less sensitive to the cold stress since the cultivation for a short period at the low temperatures did not suppress their growth. Transgenic root lines also differed in the flavonoids content which was up 3–15 mg RE/g. Cultivation of “hairy” roots under short-term cold stress has led to decrease of the flavonoids content in all “hairy“ root lines except line No. 5. Cold stress did not lead to the significant changes of antioxidant activity in any of the studied root lines except root line No. 5 where the greater antioxidant activity was observed in oneand two-day cold stress. Thus, short-term cold stress have suppressed the “hairy“ roots growth, inhibited flavonoids accumulation, and had no effect on the antioxidant activity (except one roots line).
Effects of rate and time of potassium application on yield and fiber quality of cotton(Gossyium hirsutum L.) at different fruit positions

Recently,as modern cotton(Gossyium hirsutum L.) varieties including Bt(Bacillus thuringiensis) transgenic cotton are adopted,premature senescence caused by potassium(K) deficiency has become an important problem in cotton production in the Yellow River Valley of China.The objectives of this research were to determine the effects of rate and time of potassium application on cotton yield and fiber quality at different fruit positions.Field studies were conducted in 2009 and 2010 using the cotton cultivar,Lumianyan No.28. Potassium rates of K2O 0,100 and 150 kg/ha was applied as basal dressing and as 1/2 basal dressing and 1/2 top-dressing at the blossoming and boll forming stages.Data collected in the two years indicate that the application of potassium produces significant differences in seed cotton yield and lint yield compared with the untreated control,respectively.When the K application rate is 150 kg/ha,the split application of K produces significant higher seed cotton yield and lint yield compared with the basal application,respectively.When the fertilizer K is 1/2 basal-applied and 1/2 top-dressed at the blossoming and boll forming stages,seed cotton yield and lint yield are significant increased with increases of the K application rate,respectively,and the influence of K on the number of bolls per plant is the key reason for the increase.The results also show that the micronaire values in middle and upper fruit branches and inner nodes under the K application are significant increased compared with the untreated control.Split application of K2O 150 kg/ha produces significant higher fiber lengths,fiber strength in middle fruit branches and the outer nodes and fiber maturation in middle fruit branches and inner nodes compared with the untreated control,respectively.Moreover,at the same K application time,there were no effects on fiber length and fiber strength with the increase of K application,respectively.At the same K application rate,there was no significant difference in fiber strength between basal application and split application.
Effect of Pre-Slaughter Antacid Supplementation of Drinking Water on Carcass Yield and Meat Quality of Broiler Chickens

Antacid is a mixture of sodium bicarbonate, bicarbonate, and citric acid, which can neutralize stomach acidity and may stabilize the pH of post-mortem carcass and meat. Therefore, the present study aimed to investigate the carcass and meat quality of broiler chickens by supplementing the antacid in drinking water. A total of 48 male broiler chickens (Ross 308) were divided into two groups that the first group was the control group (did not receive antacid supplementation in the drinking water) and the second group was supplemented with antacid in drinking water (0.10%) for three days pre-slaughter. It was found that the antacid supplementation increased the percentage of breast meat, while carcass yield, and thigh, drumstick, and wing were not significantly affected. The pH of breast meat 45 minutes and the drip loss at 24 hours post-slaughter was significantly higher. The shear-force of breast meat was reduced (P < 0.05) by antacid supplementation. For the color of the breast meat, there were no significant differences in lightness (L*), redness (a*), and yellowness (b*) between the two groups, but the total difference in the color of meat was slightly increased. It can be concluded that supplementing the drinking water with an antacid for three days before slaughter improves the carcass and meat quality of broiler chickens by maintaining the pH and water holding capacity of the meat.
Understanding the use of patent data along the innovation process

While research has paid attention to open innovation, we have witnessed a strong emphasis on the question of how firms can learn from patents and knowledge generated outside their organizational boundaries. In this article, we examine the way patents can be used as an input into the innovation process. To better comprehend the use of patents in this process, we focus through the lens of a leading global automotive company, which offer a particularly suitable context for such an investigation. Based on a case study, we show, step by step, how to integrate external patents throughout the different stages of the open innovation process. We then highlight specific policy implications that suggest a more holistic approach for firms intending to encourage the use of external patents. We conclude by outlining limitations of our work and proposing potential future research opportunities.
Random Under-Sampling Ensemble Methods for Highly Imbalanced Rare Disease Classiﬁcation

—Classiﬁcation on imbalanced data presents lots of challenges to researchers. In healthcare settings, rare disease identiﬁcation is one of the most difﬁcult kinds of imbalanced classiﬁcation. It is hard to correctly identify true positive rare disease patients out of much larger number of negative patients. The prediction using traditional models tends to bias towards much larger negative class. In order to gain better predictive accuracy, we select and test some modern imbalanced machine learning algorithms on an empirical rare disease dataset. The training data is constructed from the real world patient diagnosis and prescription data. In the end, we compare the performances from various algorithms. We ﬁnd that the random under-sampling Random Forest algorithm has more than 40% improvement over traditional logistic model in this particular example. We also observe that not all bagging methods are out-performing than traditional methods. For example, the random under-sampling LASSO is inferior to benchmark in our reports. Researchers need to test and select appropriate methods accordingly in real world applications.
Fabrication of wire grid polarizer for spectroscopy application: From ultraviolet to terahertz

ABSTRACT Wire grid polarizer has high extinction ratio, brightness, excellent durability and large acceptance angle of light. The interest in grid-type polarizer has maintained continuously over recent decades since it can cover from ultraviolet to terahertz range. As nanotechnology advances, size, shape and material of wire grid can be controlled by various fabrication processes. A review of fabrication, materials, simulation schemes and new designs of wire grid polarizer is presented. Additionally, research trend of wire grid polarizers in terahertz time domain spectroscopy is addressed.
Investigating the Effect of Loading Frequency on the Dynamic Properties of Sand- Tire Powder Mixture Using Shaking Table Tests

Nowadays, the use of waste tires has been expanded in various geotechnical projects to absorb and reduce the vibration caused by seismic and dynamic loads, and therefore it is crucial to study the effect of different parameters on their behavior and dynamic characteristics in combination with soil. So this study examined the effects of loading frequency on dynamic properties of sand tire powder mixtures such as shear modulus (G) and damping ratio (D). A series of 1-g shaking table tests were performed on sand tire powder mixture. Tire powders were added to the sand with 5%, 10%, 15% and 20% in gravimetric basis and with a relative density of zero were subjected to sinusoidal loading at frequencies of 0.5, 1, 2, 3, 5, 7 and 9 Hz and input acceleration of 0.1g and 0.3g. The results showed that in all cases, the increase in frequency in the same cycles increased the shear modulus and the damping ratio. Also, with increasing shear strain, the shear modulus of the mixture decreased, but the damping ratio increased. On the other hand, by increasing the tire powder, the value of the shear modulus is reduced, but the amount of damping ratio is increased. Review History: