Miracle-dz/UniFAR-FTUs huggingface dataset:
Titre : Title : Evaluation of a real-time virtual intervention to empower persons living with HIV to use therapy self-management : study protocol for an online randomized controlled trial Auteurs :

Background: Living with HIV makes considerable demands on a person in terms of self-management, especially as regards adherence to treatment and coping with adverse side-effects. The online HIV Treatment, Virtual Nursing Assistance and Education (Virus de I’immunodéficience Humaine–Traitement Assistance Virtuelle Infirmière et Enseignement; VIH-TAVIETM) intervention was developed to provide persons living with HIV (PLHIV) with personalized follow-up and real-time support in managing their medication intake on a daily basis. An online randomized controlled trial (RCT) will be conducted to evaluate the efficacy of this intervention primarily in optimizing adherence to combination anti-retroviral therapy (ART) among PLHIV. Methods/design: A convenience sample of 232 PLHIV will be split evenly and randomly between an experimental group that will use the web application, and a control group that will be handed a list of websites of interest. Participants must be aged 18 years or older, have been on ART for at least 6 months, and have internet access. The intervention is composed of four interactive computer sessions of 20 to 30 minutes hosted by a virtual nurse who engages the PLHIV in a skills-learning process aimed at improving self-management of medication intake. Adherence constitutes the principal outcome, and is defined as the intake of at least 95% of the prescribed tablets. The following intermediary measures will be assessed: self-efficacy and attitude towards antiretroviral medication, symptom-related discomfort, and emotional support. There will be three measurement times: baseline (T0), after 3 months (T3) and 6 months (T6) of baseline measurement. The principal analyses will focus on comparing the two groups in terms of treatment adherence at the end of follow-up at T6. An intention-to-treat (ITT) analysis will be carried out to evaluate the true value of the intervention in a real context. Discussion: Carrying out this online RCT poses various challenges in terms of recruitment, ethics, and data collection, including participant follow-up over an extended period. Collaboration between researchers from clinical disciplines (nursing, medicine), and experts in behavioral sciences information technology and media will be crucial to the development of innovative solutions to supplying and delivering health services. Trial registration: CE 11.184 / NCT 01510340
Antioxidant and proton potassium ATPase inhibitory activity in fruits

In the present study fruits such as Kiwi, Persimmon, Pomegranate, Dragon and Noni were screened for their antioxidant activity and H+K+ ATPase inhibitory activity. Among various mechanisms involved in the formation of gastric ulcers, free radicals generated during stress are one of the major causative factors for the gastric lesion through oxidative damage. Thus the best approach to control gastric ulcer would be to inhibit oxidative damage and acid secretion induced by the enzyme. The proton potassium ATPase inhibitory and antioxidant activity of aqueous and acetone extracts of five different fruits were investigated. The fruits were subjected to phytochemical investigations, antioxidant activity and enzyme inhibition. Among the various fruits screened Noni fruit showed 96.5% enzyme inhibition with considerable amount of phenolics and flavonoids. It showed 80% of free radical scavenging activity and 50% of anti-lipid peroxidation activity.
Portfolio insurance – a comparison of naive versus popular strategies

This study makes a comparison between the most popular strategies of portfolio insurance – OBPI, CPPI and SLPI strategies – using Monte Carlo simulation, assuming the underlying asset follows a geometric Brownian motion. The authors compare them in terms of moments of the distribution of returns, performance ratios and stochastic dominance, under different market conditions. The main result is found the naive CPPI 1 and SLPI strategies perform better in all scenarios. The authors also find that the CPPI 1 strategy stochastically dominates, on second and/or third order, the other strategies in bear market scenarios. CPPI strategies, with a multiplier higher than 1, have the worst performances and present extremely high probabilities of reaching (or being extremely close to) the floor. When using real stock market data the results are similar, i.e. naive strategies outperform the standard portfolio insurance strategies.
Effect of Garden Cress (Lepidium sativum) Extracts on Aflatoxin B1 and Blood Parameters in Rats

The crude chloroform and methanol extracts of Lepidium sativum seeds belong to family Brassicaceae,were used in this work to study their efficiency to reduce Aflatoxin B1 in rats. The more effective of chloroformic extract which decreased Aflatoxin B1 level from 8.7 to 1.0 ppb at a dose of 300 mg/kg body weight comparing with ligalon (Silymarin) which reduced Aflatoxin B1 to 0.97 ppb in concentration of 100 mg/kg after 5 weeks, followed by methanolic extract at a dose of 300 mg/kg body weight which showed the mean value of 1.2 ppb.Also, the more effective treatments may be Silymarin in concentration of 100 mg/kg followed by chloroformic extract, while methanolic extract of Lepidium sativum seeds was represented middle effect for blood tests of rats injured with Aflatoxin B1 e.g. Serum marker enzyme parameters (MDA, SOD, ALP and Bilirubin), kidney functions (Creatinine and Urea), liver functions (ALT, AST, Total proteins, Albumin and Globulins), lipid profile (triglycerides, total cholesterol, HDL-c, LDL-c and vLDL-c ) and haematological parameters (HB, RBCs, Plt and WBCs), were determined in injured rats comparing with control rats. It is quite clear that Silymarin is considered synthetic product, so the natural extracts of garden cress are more suitable for usage due to, they considered more safety and economic products, so these extracts can be additive to foodstuffs and therapeutic drugs owing to their multi medicinal benefits.
Analysis of Overclocked PN Sequences in Sub-Nyquist Sampling for Wideband Sparse Signals

High-speed ADCs operating at the order of Gsps consume high power and have limited bit resolution [1]. Sub-Nyquist sampling overcomes the necessity of high-speed ADCs for sampling wideband sparse signals. Instead of using a high-speed ADC, a wideband sparse signal can be acquired by using low-speed ADCs with the complementary mixing process [2]. In this field of research a lot of works have been done in theoretical and proof-ofconcept implementation level. However, in the implementation aspect, many issues have not been fully discussed in previous works [2][3]. Among them, this work analyzes the effect of PN chipping frequencies. Because the spectrum of PN sequences is attenuated at high frequency due to their square-shaped pulse, compensation is necessary for the proper sampling. To reduce the attenuation factor within the frequency range of an input signal and consequently reduce the dependency on the compensation, we apply overclocked PN sequences to the mixing stage. In this work, we analyze and clarify the trade-off of it by a simulation. The result shows that the higher chipping frequency without the compensation can reduce sampling error approaching the performance when the compensation is applied. On the other hand, the system with overclocked PN sequences becomes less tolerance to a measurement noise which occurs due to circuit nonidealities.
Universitet YAP 1 regulates prostate cancer stem cell-like characteristics to promote castration resistant growth

Castration resistant prostate cancer (CRPC) is a stage of relapse that arises after various forms of androgen ablation therapy (ADT) and causes significant morbidity and mortality. However, the mechanism underlying progression to CRPC remains poorly understood. Here, we report that YAP1, which is negatively regulated by AR, influences prostate cancer (PCa) cell self-renewal and CRPC development. Specifically, we found that AR directly regulates the methylation of YAP1 gene promoter via the formation of a complex with Polycomb group protein EZH2 and DNMT3a. In normal conditions, AR recruits EZH2 and DNMT3a to YAP1 promoter, thereby promoting DNA methylation and the repression of YAP1 gene transcription. Following ADT treatment or when AR activity is antagonized by Bicalutamide or Enzalutamide, YAP1 gene expression is switched on. In turn, YAP1 promotes SOX2 and Nanog expression and the de-differentiation of PCa cells to stem/progenitor-like cells (PCSC), which potentially contribute to disease recurrence. Finally, the knock down of YAP1 expression or the inhibition of YAP1 function by Verteporfin in TRAMP prostate cancer mice significantly suppresses tumor recurrence following castration. In conclusion, our data reveals that AR suppresses YAP1 gene expression through a novel epigenetic mechanism, which is critical for PCa cells self-renewal and the development of CRPC.
Root Medium Chemical Properties

Acceptable physical properties are an integral part of root-media quality. However, there is no one growing medium that works best in all situations because root-media physical properties are not constant, but rather can be affected by the grower. Understanding the root environment under production conditions requires an understanding of the dynamic nature of air : water : solid ratio in the medium. The objective of this review is to consider key aspects of root-medium physical properties, which include bulk density and particle size, container capacity, media settling, water absorption, rewettability, moisture release characteristics, and water loss due to evaporation from the root-medium surface.
Response to comments

To the Editor: Concerning the comment on the study “Health technology assessment agencies: An international overview of organizational aspects,” here are our responses. Our study summarizes the results of a research project carried out during 2004–06. Data acquisition was performed at the very end of 2004 and in mid 2006. Agencies were included in the interview on the basis of their INAHTA membership at that time, and this explains the absence of some, more recent, INAHTA members. We want to emphasize that there was no “selection” process driven by the researchers; however, several agencies were nonresponders. It must be remembered that answering a questionnaire is a voluntary act, so there is no means to guarantee an answer from a very important organization, such as the AHRQ or others. We agree, however, that the absence of a response/results from some large or otherwise important organizations could have an impact on the outcome of the analysis. We are well aware that, from the start of the project until our study was published, some agencies were renamed. Moreover, in more than in one case, we received questionnaires from agencies that were renamed months before still carrying the old affiliation. In addition, some of the agencies continued to publish information under their old name (see for example, INAHTA Brief 2005/49 for ANAES). Excluding from the survey academic institutes because of a supposed lack of regulatory impact would have been a clear bias in the study. It is well known that even governmental agencies very often lack regulatory power. Regarding the matter of legal mandate, we decided to investigate an indirect effect of this aspect in the form of “prescriptiveness,” because legal mandates are not reliable indicators of “regulatory power” because they are heavily dependent on the type of healthcare organization in the corresponding country.
Title Simultaneous pancreas-kidney transplantation : Initial experience of acenter in Japan

Background: Simultaneous pancreas-kidney transplantation (SPK) is an established therapy for diabetes mellitus (DM) patients with associated end stage renal disease. We report the initial results of SPK in our institution after qualification as transplantation program. Patients and methods: Between September 2017 and July 2018, we performed 3 SPK in type 1 diabetic patients with end-stage renal disease. All grafts were procured from brain-dead marginal donors according Pittsburg criteria. Results: The recipients were 2 men and 1 woman with a mean age of 43 ± 5.4 years. Mean time from DM diagnosis and time on dialysis were 25.7 ± 3.9 years and 19.7 ± 9.1 months. The mean age and HbA1C value of donor were 56.7 ± 0.5 years and 5.67 ± 0.05%. The pancreatic grafts were transplanted intraperitoneally in the right iliac fossa. Two patients required a relaparotomy due to arterial anastomotic hemorrhage and two patients developed acute cellular rejection. With a median follow-up of 13 (6–15) months, patient's and graft's survival rate were 100%. All patients showed HbA1C within normal range, but oral glucose tolerance test showed DM pattern in two patients at 3 months after transplantation. Conclusions: In our initial experience with SPK, mid-term grafts and patient survival appear comparable to the results reported in literature. Despite the limited availability of donors and the use of grafts from marginal donors, a quality pancreas transplantation program can be established even in a small-volume centers. Nonetheless further improvement in surgical techniques and meticulous management appear mandatory.
Competence approach to foreign languages teaching of future specialists in Belarus

Artykuł zawiera krótki przegląd kompetencyjnie zorientowanego podejścia do nauczania języków obcych oraz jego podstawowych zasad. Komunikacyjne ukierunkowanie na nauczanie języków obcych jest podstawową zasadą współczesnych programów nauczania. W opracowaniu przedstawiono analizę i wyjaśnienie pojęć „fachowość” oraz „kompetencja”, ustalono integralną strukturę i treść językowej komunikacyjnej kompetencji, uzasadniono także wybór kluczowych kompetencji niezbędnych dla każdego oraz funkcjonalnie skierowanych kompetencji, które w swojej jedności zapewniają sukces przy adaptacji i samorealizacji młodego specjalisty we współczesnym dynamicznym świecie. Szczególną uwagę poświęcono rozwojowi międzykulturowej komunikacyjnej kompetencji realizowanej przez różne rodzaje aktywności.
Application of TLC for Evaluation of the Lipophilicity of Newly Synthetized Esters: Betulin Derivatives

The problem of designing a new drug is nowadays very important for researches representing many branches of science. This work considers the usefulness of the analytical method such as thin-layer chromatography for the lipophilicity of newly synthesized compounds, betulin derivatives, which could be potential drugs with anticancer activity. The two mobile phases were used for the purpose of experimental determination of lipophilicity for mono- and diesters investigated. The first mobile phase consists of acetate and Tris buffer, whilst the second consists of 1,4-dioxane and acetate buffer. The value of the retardation factor was recalculation into the RM value, and then RM0 values were obtained by extrapolating acetone or 1,4-dioxane concentration to zero. The chromatographic data of lipophilicity were correlated with theoretically obtained values of ALOGPS, AClogP, miLogP, ALOGP, MLOGP, XLOGP2, and XLOGP3. The particular correlation equations were obtained. The cluster analysis was also used to find similarity between the esters investigated on the basis of the experimental or theoretical value of lipophilicity obtained. The good correlation between experimentally and theoretically calculated lipophilicity gives the possibility of prediction of this value on the basis of the correlation equation. On the basis of similarity analysis was stated strong connections between the structure and the value of lipophilicity, for both experimental and theoretical values.
Portable Reading Assistant Headset for the Visually Impaired (PRAHVI)

Most products in the domain of assisting people with visual disabilities interpret text focus on the direct translation or dictation of text that is in front of a user. The focus is seldom on any type of textual understanding that goes beyond literal translation. In this project, we have developed the implementation of a novel wearable system that allows the visually impaired to have a better understanding of the textual world around them. Using the equivalent of a typical smartphone camera, a device captures a feed of the user’s surroundings. Pre-processing algorithms for adjusting white-balance and exposure and detecting blurriness are then employed to optimize the capture. The resulting images are sent to the user’s smartphone to be translated into text. Finally, the text is read aloud using an app that the user can control using touch and haptic feedback. The back-end of this system continuously learns from these captures over time to provide more significant and natural feedback based on a user’s semantic queries regarding the text before them. This document includes the requirements, design, use cases, risk tables, workflow and the architecture for the device we developed.
The Competitive Dynamics of Openness

While firm competitive advantage is normally couched in terms of control, an increasing body of research is providing empirical and theoretical support of how firms use selective openness to achieve strategic goals. Such openness may be used both to grow the industry, and to gain competitive advantage within an industry. Here, building on a novel conceptualization of what firms open, how they open and to what degree they are open, we apply on the resource-based view to develop a theoretical model explaining the initial, unilateral, firm decision for openness. We then apply this model to predict differing impacts on the competitive dynamics of the industry, as well as upon firm and industry success, and discuss implications for theories of strategy and innovation.
Newly synthesized claudins but not occludin are added to the basal side of the tight junction

A network of claudin strands creates continuous cell–cell contacts to form the intercellular tight junction barrier; a second protein, occludin, is associated along these strands. The physiological barrier remains stable despite protein turnover, which involves removal and replacement of claudins both in the steady state and during junction remodeling. Here we use a pulse–block–pulse labeling protocol with fluorescent ligands to label SNAP/CLIP-tags fused to claudins and occludin to identify their spatial trafficking pathways and kinetics in Madin–Darby canine kidney monolayers. We find that claudins are first delivered to the lateral membrane and, over time, enter the junction strand network from the basal side; this is followed by slow replacement of older claudins in the strands. In contrast, even at early times, newly synthesized occludin is found throughout the network. Taking the results together with our previous documentation of the mechanism for claudin strand assembly in a fibroblast model, we speculate that newly synthesized claudins are added at strand breaks and free ends; these are most common in the basalmost edge of the junction. In contrast, occludin can be added directly within the strand network. We further demonstrate that claudin trafficking and half-life depend on carboxy-terminal sequences and that different claudins compete for tight junction localization.
International Workshop on Spoken Language Translation : IWSLT 2008 in Hawaii : Evaluation Campaign on Spoken Language Translation : October 201-21 , 2008 : proceedings

The QMUL system to the IWSLT 2008 evaluation campaign is a phrase-based statistical MT system implemented in C++. The decoder employs a multi-stack architecture, and uses a beam to manage the search space. We participated in both BTEC Arabic → English and Chinese → English tracks, as well as the PIVOT task. In our first submission to IWSLT, we are particularly interested in seeing how our SMT system performs with speech input, having so far only worked with and translated newswire data sets.
Quality of Life Assessment among Adult Epileptic Patients Taking Follow Up Care at Jimma University Medical Center , Jimma , South West Ethiopia : Using Quality of Life in Epilepsy Inventory-31 instrument By

Introduction: Epilepsy is neurological disorder which affects patient’s quality of life and their close social networks. Thus, this study assessed quality of life and associated factors among adult epileptic patients taking follow up care at Jimma University Medical Center from March 1 – 1 May, 2015. Methods: Institution based cross sectional study was used. A total of 314 epilepsy patients already receiving antiepileptic drugs for at least 3 months were randomly selected and interviewed. Quality of life in epilepsy inventory-31instrument was used to measure health quality of life. T-test, one way Anova and Pearson correlation were used to compare means and association between dependent and outcome variables. Multiple Linear regression analysis was performed to assess the association between health related quality of life and explanatory variables. P value < 0.05 was considered statistically significant in
Survey of Business Perception Based on Sentiment Analysis through Deep Neuronal Networks for Natural Language Processing

In recent years, the machine-learning field, deep neural networks has been an important topic of research, used in several disciplines such as pattern recognition, information retrieval, classification and natural language processing. Is in the last that this paper it’s going to be our principal topic, in this branch exist an specific task that in literature is called Sentiment Analysis were the principal function is to detect if an opinion is positive or negative. The paper shows how use this subset of the machine learning knowledge and use it for give us an insight in the question: what is the perception in a business or a product by means of the opinion of the consumers in social networks?
VIDEO PROFIL SEBAGAI SARANA PROMOSI EFEKTIF DALAM MENUNJANG EKSISTENSI PROGRAM STUDI MANAJEMEN INFORMATIKA

Video profil merupakan sebuah media elektronik untuk menyampaikan informasi yang sangat efektif dalam memperkenalkan suatu Prodi. Melalui media visual inilah maka semua informasi dapat dengan mudah dicerna oleh semua kalangan masyarakat. Prodi Manajemen Informatika adalah Prodi berada di Fakultas Teknik dan Kejuruan, Universitas Pendidikan Ganesha (Undiksha). Prodi ini, membutuhkan media promosi untuk sosialisasi kepada masyarakat untuk meningkatkan eksistensinya setelah melakukan perombakan kurikulum 2012 menjadi 2016. Berdasarkan hal tersebut, maka untuk melakukan promosi maka dikembangkan sebuah video profil Prodi Manajemen Informatika Undiksha. Dalam pembuatan video ini, digunakan Software Adobe Premiere Pro dan Adobe After Effects sehingga akan memudahkan pembuatan video profil. Dalam pembuatan Video Profil tahapan yang akan dibuat dimulai dari tahap Pra Produksi (Persiapan Ide, pengerjaan video, dan dialog atau Storyboard), Tahap Produksi (proses pengambilan gambar), Tahap Paska Produksi (Editing Video) serta elemen-elemen yang ada setiap tahapnya. Hasilnya berupa video profil yang digunakan untuk mempromosikan Prodi Manajemen Informatika.
Microbial Gimics: Strategies of Successful Pathogenicity by Staphylococcus aureus

Staphylococcus aureus is a major human pathogen associated with a variety of clinical diseases. It is the leading cause of wound infections, skin infections, respiratory infections as well as device-related infections. This review comprehensively covers the virulence determinants of the organism and the different mechanisms of antibiotic resistance in the organism. Recently, Staphylococcus aureus has become a serious threat because of its ability to evolve which has led to challenges in the treatment of infections caused by the organism.