Miracle-dz/UniFAR-FTUs huggingface dataset:
Videosprechstunden im berufsgenossenschaftlichen Heilverfahren – Anwendungsmöglichkeiten und ökonomische Evaluation

Zusammenfassung Ziel Videosprechstunden erlangen eine immer größere Bedeutung im Gesundheitswesen, da sie neue Behandlungskonzepte ermöglichen. Seit 2017 haben Videosprechstunden Einzug in die Regelversorgung der gesetzlichen Krankenversicherung gehalten, für das berufsgenossenschaftliche Heilverfahren fehlen bisher vergleichbare Angebote. Im Rahmen dieses Beitrags werden Anwendungsmöglichkeiten für eine Videosprechstunde im berufsgenossenschaftlichen Heilverfahren erörtert und eine ökonomische Bewertung vorgenommen. Methodik Auf der Grundlage einer erfahrungsgestützten Analyse werden potentielle Anwendungsmöglichkeiten einer Videosprechstunde im berufsgenossenschaftlichen Heilverfahren erörtert. Die jeweiligen Leistungsinhalte wurden mit existierenden Gebührenordnungsziffern der UV-GOÄ bewertet. Ergebnisse Videosprechstunden bergen im berufsgenossenschaftlichen Heilverfahren nicht nur als Verlaufskontrolle ein Nutzenpotenzial, sondern auch als Erstkontakt zur Vorbereitung aufwändiger Untersuchungstermine und bei Fallkonferenzen. Wenngleich Videosprechstunden in der UV-GoÄ bisher noch nicht abgebildet werden, existieren doch inhaltlich vergleichbare Abrechnungsziffern für andere Leistungen. Schlussfolgerung Videosprechstunden bieten das Potenzial, sowohl die Qualität des berufsgenossenschaftlichen Heilverfahrens zu verbessern als auch zu einer Kostensenkung beizutragen. Da mit einer zunehmenden Bedeutung von Videosprechstunden zu rechnen ist, sollten Videosprechstunden als Regelleistung in das berufsgenossenschaftliche Heilverfahren aufgenommen und adäquate Abrechnungsmöglichkeiten erarbeitet werden.
The Role of Retinoic Acid in Establishing the Early Limb Bud

Retinoic acid (RA) was one of the first molecules in the modern era of experimental embryology to be shown capable of generating profound effects on limb development. In this review, we focus on the earliest events of limb development and specifically on the role of RA in establishing the domain of cells that will go on to form the limb itself. Although there is some consensus on the role of RA during the earliest stages of limb formation, some controversy remains on the mechanism of RA action and the requirement for RA signaling in forming the hindlimb buds.
An extended model for phylogenetic maximum likelihood based on discrete morphological characters

Abstract Maximum likelihood is a common method of estimating a phylogenetic tree based on a set of genetic data. However, models of evolution for certain types of genetic data are highly flawed in their specification, and this misspecification can have an adverse impact on phylogenetic inference. Our attention here is focused on extending an existing class of models for estimating phylogenetic trees from discrete morphological characters. The main advance of this work is a model that allows unequal equilibrium frequencies in the estimation of phylogenetic trees from discrete morphological character data using likelihood methods. Possible extensions of the proposed model will also be discussed.
Development of a four-gene prognostic model for pancreatic cancer based on transcriptome dysregulation

We systematically developed a prognostic model for pancreatic cancer that was compatible across different transcriptomic platforms and patient cohorts. After performing quality control measures, we used seven microarray datasets and two RNA sequencing datasets to identify consistently dysregulated genes in pancreatic cancer patients. Weighted gene co-expression network analysis was performed to explore the associations between gene expression patterns and clinical features. The least absolute shrinkage and selection operator (LASSO) and Cox regression were used to construct a prognostic model. We tested the predictive power of the model by determining the area under the curve of the risk score for time-dependent survival. Most of the differentially expressed genes in pancreatic cancer were enriched in functions pertaining to the tumor immune microenvironment. The transcriptome profiles were found to be associated with overall survival, and four genes were identified as independent prognostic factors. A prognostic risk score was then proposed, which displayed moderate accuracy in the training and self-validation cohorts. Furthermore, patients in two independent microarray cohorts were successfully stratified into high- and low-risk prognostic groups. Thus, we constructed a reliable prognostic model for pancreatic cancer, which should be beneficial for clinical therapeutic decision-making.
The adoption of electronic medical record by physicians

Abstract Background: The electronic medical record (EMR) is considered to be a vital tool of information and communication technology (ICT) to improve the quality of medical care, but the limited adoption of EMR by physicians results in a considerable warning to its successful implementation. The purpose of the present review is to explore and identify the potential barriers perceived by physicians in the adoption of EMR. Methods: The systematic review was carried out based on literature published in 5 databases: PubMed, Web of Science, Scopus, The Cochrane Library, and ProQuest from 2014 to 2018, concerning barriers perceived by physicians to the adoption of EMR. Results: The present study incorporates 26 articles based on their appropriateness out of 1354 for the final analysis. Authors explore 25 barriers that appeared 112 times in the literature for the present review; the top 5 frequently mentioned barriers are privacy and security concerns, high start-up cost, workflow changes, system complexity, lack of reliability, and interoperability. Conclusion: The systematic review explores that physicians deal with different barriers as they intend to adopt EMR. The barriers explored in the present review are the potential to play as references for the implementer of the EMR system. Thus an attentive analysis of the definitive condition is needed before relevant intervention is determined as the implementation of EMR must be considered as a behavioral change in medical practice.
Digestive Stability and Bioaccessibility of Antioxidants in Prickly Pear Fruits from the Canary Islands: Healthy Foods and Ingredients

Although prickly pear fruits have become an important part of the Canary diet, their native varieties are yet to be characterized in terms of betalains and phenolic compounds. To exert potential health benefits, these antioxidants must be released from the food matrix and be stable in the gastrointestinal tract. Our aim was to characterize the betalain and phenolic profile of four prickly pear varieties from the Canary Islands (Spain) and determine their digestive stability and bioaccessibility via in vitro gastrointestinal digestion. Digestive studies were performed considering the (i) importance of the edible fraction (pulps) and (ii) potential of fruit peels as by-products to obtain healthy ingredients. Betalains and phenolic profiles were analyzed by HPLC-DAD-ESI/MS and HPLC-DAD-MS/QTOF. Pulps in Colorada and Fresa varieties presented high indicaxanthin and betanin content, respectively. Despite low pH in the gastric phase, betalains were stable to reach the intestinal phase, although indicaxanthin presented a higher bioaccessibility. Blanco Buenavista peels contained a distinct flavonoid profile including a new isorhamnetin-hexosyl-rhamnoside. Phenolic compounds were abundant and highly bioaccessible in fruit peels. These findings suggest that prickly pear pulps are rich in bioaccessible betalains; and that their peels could be proposed as potential by-products to obtain sustainable healthy ingredients.
Biogeographical variation in diurnal behaviour of Acanthaster planci versus Acanthaster cf. solaris

Crown-of-thorns starfish (CoTS; Acanthaster spp.) are among the most extensively studied coral reef taxa, largely owing to their devastating impacts on live coral cover during population outbreaks. Much of this research has however, been conducted in the western Pacific, although it is now apparent that there are several distinct species of Acanthaster spp. across the Indo-Pacific. The purpose of this study was to test for biogeographical variation in behaviour, comparing between Acanthaster planci at Lankanfushi Island in the Maldives and Acanthaster cf. solaris at Rib Reef on Australia’s Great Barrier Reef. The extent to which CoTS were exposed (cf. concealed within or beneath coral substrates) was substantially higher (63.14%) for A. planci at Lankanfushi Island, compared to 28.55% for A. cf. solaris at Rib Reef, regardless of time of day. More importantly, only 52% of individuals were exposed at night at Rib Reef compared to >97% at reefs around Lankanfushi Island. Biogeographic variation in the behaviour of Acanthaster spp. was independent of differences in the size structure of starfish and coral cover at specific study sites, but may be attributable to other environmental factors such as habitat complexity or prey availability. This is the first study to explicitly test for biogeographical differences in the biology and behaviour of Acanthaster spp. , potentially linked to species-specific differences in the causes and explanations of population outbreaks. However, we did not find evidence at this stage of differences in behavior among regions, rather behavioural differences observed were most likely products of different environments.
Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis

We find that pro-inflammatory activation is required for remyelination after myelin injury. We impaired inflammatory signaling and found that microglia in lesioned animals were defective in phagosome maturation, debris clearance, and also in triggering the generation of new oligodendrocytes, a process which required TNF-α.
Antibacterial Effect of Zinc Oxide-Based Nanomaterials on Environmental Biodeteriogens Affecting Historical Buildings

The colonization of microorganisms and their subsequent interaction with stone substrates under different environmental conditions encourage deterioration of materials by multiple mechanisms resulting in changes in the original color, appearance and durability. One of the emerging alternatives to remedy biodeterioration is nanotechnology, thanks to nanoparticle properties such as small size, no-toxicity, high photo-reactivity, and low impact on the environment. This study highlighted the effects of ZnO-based nanomaterials of two bacteria genera isolated from the Temple of Concordia (Agrigento’s Valley of the Temples in Sicily, Italy) that are involved in biodeterioration processes. The antimicrobial activities of ZnO-nanorods (Zn-NRs) and graphene nanoplatelets decorated with Zn-NRs (ZNGs) were evaluated against the Gram positive Arthrobacter aurescens and two isolates of the Gram negative Achromobacter spanius. ZNGs demonstrated high antibacterial and antibiofilm activities on several substrates such as stones with different porosity. In the case of ZNGs, a marked time- and dose-dependent bactericidal effect was highlighted against all bacterial species. Therefore, these nanomaterials represent a promising tool for developing biocompatible materials that can be exploited for the conservation of cultural heritage. These nanostructures can be successfully applied without releasing toxic compounds, thus spreading their usability.
Effects of ignoring inbreeding in model-based accuracy for BLUP and SSGBLUP.

Model-based accuracy, defined as the theoretical correlation between true and estimated breeding value, can be obtained for each individual as a function of its prediction error variance (PEV) and inbreeding coefficient F, in BLUP, GBLUP and SSGBLUP genetic evaluations. However, for computational convenience, inbreeding is often ignored in two places. First, in the computation of reliability = 1-PEV/(1 + F). Second, in the set-up, using Henderson's rules, of the inverse of the pedigree-based relationship matrix A. Both approximations have an effect in the computation of model-based accuracy and result in wrong values. In this work, first we present a reminder of the theory and extend it to SSGBLUP. Second, we quantify the error of ignoring inbreeding with real data in three scenarios: BLUP evaluation and SSGBLUP in Uruguayan dairy cattle, and BLUP evaluations in a line of rabbit closed for >40 generations with steady increase of inbreeding up to an average of 0.30. We show that ignoring inbreeding in the set-up of the A-inverse is equivalent to assume that non-inbred animals are actually inbred. This results in an increase of apparent PEV that is negligible for dairy cattle but considerable for rabbit. Ignoring inbreeding in reliability = 1-PEV/(1 + F) leads to underestimation of reliability for BLUP evaluations, and this underestimation is very large for rabbit. For SSGBLUP in dairy cattle, it leads to both underestimation and overestimation of reliability, both for genotyped and non-genotyped animals. We strongly recommend to include inbreeding both in the set-up of A-inverse and in the computation of reliability from PEVs.
The disadvantage of morning blood pressure management in hypertensive patients

Abstract To investigate whether the control of morning blood pressure (MBP) reflects the control of blood pressure (BP) in other periods (daytime, nighttime and 24-hour) and to assess whether morning BP displays a closer association with subclinical target organ damage (TOD) than the BP measured in other periods. One thousand one hundred forty patients with primary hypertension who completed subclinical TOD detection and 24-hour ambulatory BP monitoring were included in the analysis. Pearson correlation analysis, Kappa consistency test, multiple linear regression analysis, and area under the receiver operating curve were used to analyze the data. Morning BP and daytime BP displayed good agreement, but not 24-hour BP , particularly the nighttime BP (all P < .001). Approximately 39.4% of the hypertensive patients receiving drug treatment who had achieved control of the morning BP presented masked nocturnal hypertension, which was associated with worse subclinical TOD. The BP measured in all periods correlated with subclinical TOD, and the correlation was more obvious in the treatment subgroup. However, morning BP did not independently affect subclinical TOD. Morning BP appeared to exhibit less discriminatory power than nighttime BP, particularly with respect to the urinary albumin to creatinine ratio. The use of morning BP for monitoring during hypertension management may not be enough. Masked uncontrolled nocturnal hypertension should be screened when morning BP is controlled.
Correlation of E-cadherin Immunohistochemical Expression with Histopathological Grading of Oral Squamous Cell Carcinoma

Objectives: The current research was undertaken with an aim to correlate the expression of E-cadherin with histopathological grading in oral squamous cell carcinoma (OSCC) patients. Further, the objectives of the study were to evaluate the qualitative and quantitative expressions of E-cadherin in OSCC and to correlate the number of tumor cells of OSCC, immunopositive for E-cadherin with histopathological grading of OSCC. Materials and Methods: Immunoexpression of E-cadherin antibody was evaluated in previously diagnosed, paraffin-embedded sections of 20 tissues each of well-differentiated and moderately differentiated OSCC, 17 tissues of poorly differentiated OSCC, and 10 tissues of normal oral mucosa; Chi-square test, analysis of variance, and Tukey's honestly significant difference test were employed for statistical analysis. Results: E-cadherin immunoreactivity was inversely correlated to the loss of cell differentiation. There was a significant decrease in expression of E-cadherin (P < 0.0001) in advanced cases of OSCC. Furthermore, there was a significant reduction in intensity of E-cadherin expression with advancing histological grades of OSCC. Conclusion: From the present study, it is concluded that the reduced expression of E-cadherin may be a reliable indicator of increase in the invasiveness of OSCCs.
Comparative study of ultra-high-performance supercritical fluid chromatography and ultra-high-performance liquid chromatography to simultaneous determination of ten components in Radix hedysari

Background: In China, dried root of Hedysarum polybotrys Hand-Mazz, known as Hong Qi (Radix hedysari [RH]), is one of the important traditional Chinese medicines (TCMs). The long analysis time was a major limitation when high-throughput techniques are required for research or quality control purposes. Materials and Methods: It is necessary to develop a high? throughput method for the determination of multiple components of TCMs by investigating the separation characteristics of the target with ultra-high-performance liquid chromatography (UHPLC) and ultra-high-performance supercritical fluid chromatography (UHPSFC). Objective: This study intends to establish a high-throughput method for simultaneous determination of ten compounds in RH by UHPSFC and to develop a standardized method to comprehensively evaluate the quality of RH samples. In addition, this study was based on UHPLC and UHPSFC systems to understand and compare the effects of different separation parameters on ten target compounds in RH. A high-throughput and reliable solid-phase extraction method for simultaneous detection of ten target compounds in RH was established and validated. Results: The optimal analysis method was achieved using HSS C18SB column, gradient elution, flow rate of 1.5 mL/min, diode array detection at 270 nm, and back pressure at 12.41 Mpa. The separation method was validated sufficiently by examining the precision, recoveries, linearity, range, limit of detection, and limit of quantification and was successfully applied to quantify the 25 RH samples. In addition, the comparative study also demonstrated the complementary nature of the two separation modes. Conclusion: This is the first study that ten compounds in RH were separated and analyzed simultaneously with UHPSFC-diode array detector. In addition, under the separation conditions of UHPSFC and UHPLC, the comparison of chromatographic parameters shows that a combination of these two separation techniques efficiently separates the ten target compounds in RH. The results obtained in this study are useful for future TCM quality control and high-throughput analysis.
The impact of pairing a wearable movement tracker with an online community weight loss intervention.

Evidence supports the use of technology supported multicomponent interventions for promoting weight loss. Many such programs include the opportunity to synchronously pair commercially available physical activity trackers (PA-T) with a goal to enhance weight loss outcomes. However, little is known about the reach and effectiveness of allowing participants to pair a PA-T within an existing online program. PURPOSE This matched cohort, quasi-experimental study aimed to determine 1) the proportion of participants that pair a PA-T to the existing program, 2) the representativeness of participants who pair a PA-T; 3) the relationship between pairing a PA-T, overall weight loss, and the likelihood of achieving a clinically meaningful weight loss; and 4) if pairing a PA-T with program participation is related to weight loss outcomes independently or collectively when considering other indices of program engagement. METHODS Data collected over a four-year period included demographic self-report, objective weight data uploaded when participants weighed themselves at a self-serve program kiosk available to the community, and program engagement data (e.g., logins to program website). A range of analyses, including descriptive proportions, analyses of variance, and path analyses, were used to address the purposes of the study. RESULTS Participants who paired a PA-T were more likely to be women (p<.001), African American (p<.001), and have a higher BMI (p<.05). Those who paired a PA-T lost on average an extra 1% body weight and were 1.4 times more likely to lose 5% body weight. Pairing a PA-T was related to other indices of online program engagement and both directly and indirectly contributed to weight loss outcomes (p<.05). CONCLUSIONS Pairing a PA-T within an online weight loss program appeals to groups that experience disparities related to obesity and predicts improvements in weight loss. More translational studies are needed to examine the role of personal psychosocial and environmental factors that may enhance or diminish the benefit of pairing a PA-T to evidence-based, online weight loss programs.
Binding Pancreaticojejunostomy: Is It Safe?

Background: Postoperative pancreatic fistula (POPF) or leak from pancreaticojejunostomy (PJ) is one of the most common complications after pancreaticoduodenectomy (PD), with an incidence of 5%–30%. Various techniques have been advocated to bring down the incidence of POPF, but there is still none that can be called the “gold standard”. Peng's binding PJ (BPJ) was proposed as a good method of performing PJ with low fistula rates; we present our results with BPJ. Methods: The data of all patients who underwent PD with BPJ between January 2016 and March 2018 were retrospectively analyzed for demographics, clinical features, type of procedure performed, complications (especially POPF), hospital stay, morbidity, and mortality. Results: A total of 24 patients (18 males and 6 females) were identified. The mean age at the diagnosis was 65.5 ± 6.4 years. Majority of the patients had ampullary carcinoma (62.5%). The most common postoperative complication was delayed gastric emptying seen in 10 patients, whereas only 2 (8.33%) had POPF and there was one mortality. Conclusion: BPJ is safe and is associated with a low incidence of POPF.
Os odontoideum

• Clinical and radiographic surveillance or posterior C1-C2 internal fixation and fusion are recommended for patients with os odontoideum without symptoms or neurological signs. • Posterior C1-C2 internal fixation and fusion are recommended for patients with os odontoideum with neurological symptoms, signs, or C1-C2 instability. • Postoperative halo immobilization is recommended as an adjunct to posterior internal fixation and fusion unless rigid C1-C2 internal fixation is accomplished. • Occipital-cervical internal fixation and fusion with or without C1 laminectomy is recommended in patients with os odontoideum who have irreducible dorsal cervicomedullary compression and/or evidence of associated occipital-atlantal instability. • Ventral decompression should be considered in patients with os odontoideum who have irreducible ventral cervicomedullary compression.