Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Fiber Surface Modification on the Interfacial Adhesion and Thermo-Mechanical Performance of Unidirectional Epoxy-Based Composites Reinforced with Bamboo Fibers

In this work, bamboo fibers are chemically modified with NaOH solution of 1, 4, and 7 wt% concentrations at room temperature, respectively, and subsequently the untreated and treated fibers are prepared with epoxy resin for unidirectional composites by hot pressing molding technique. Tensile and micro-bond tests are conducted on the composite specimens to obtain mechanical properties, such as tensile strength and modulus, elongation at break, and interfacial strength. Besides, scanning electron microscopy (SEM) is employed to perform morphological observations for constituent damages. In addition, the influence of alkali concentration on the thermal performance of epoxy-based composites is examined by using differential scanning calorimetry (DSC) and thermogravimetric (TG) analysis. It is found that composite tensile strength reaches the maximum when the alkali concentration is 4%, increased by 45.24% compared with untreated composites. The composite elongation at break increases on increasing the concentration. Inversely, the composite modulus decreases as the concentration increases. Besides, the results demonstrate that the chemical treatment on the fiber surface could improve interface adhesion, as observed from its topography by SEM. Micro-bond test reveals that there is maximum interfacial shear strength when the alkali concentration is 4%, which increases by 100.30% in comparison with the untreated samples. In case of thermal properties, the DSC analysis indicates that the glass transition temperature is maximized at 4% alkali concentration, which is increased by 12.95%, compared to those from unmodified fibers. In addition, TG results show that the 4% concentration also facilitates thermal stability improvement, indicative of superior interfacial bonding.
Medical Mistrust and PrEP Perceptions Among Transgender Women: A Cluster Analysis

Abstract Transgender (trans) women experience unique barriers in accessing preventative health services such as HIV preexposure prophylaxis (PrEP). These barriers may be exacerbated by past real or anticipated mistreatment in health care settings, but little is known about the relationship between medical mistrust and poor PrEP uptake and knowledge. Using a multistep approach, this study used a novel survey instrument administered to a pilot sample of 78 trans women. Item responses on a 0–10 scale were subjected to a TwoStep cluster analysis to explore how perceptions of PrEP and experiences with health care vary among trans women. Two distinct clusters (C1,C2) were defined on the basis of race (C1: 82% White, C2: 69% Black) and highest level of education completed (C1: 53% college or above, C2: 42% high school diploma or GED). Analyses suggest that varying levels of medical mistrust exist between clusters. Higher mean scores on medical mistrust items were reported in C1. A similar relationship was found on attitudes toward PrEP. Differences in intention to use PrEP and differences in past PrEP use were not significant; however, C2 members were more likely to have heard of PrEP from a doctor. Results suggest that levels of medical mistrust and PrEP perceptions vary among distinct subpopulations in this community, which may affect willingness to use PrEP. Interventions aimed at addressing unique perceptions in subpopulations could move trans women from intention to PrEP use.
Evaluation of 3D re-cellularized tissue engineering: a drug-induced hepatotoxicity model for hepatoprotectant research

Abstract Background: Application of hepatoprotectants, such as drugs or cytokines, can reduce drug-induced hepatotoxicity (DIH). Due to species-specific differences and abnormal cell polarity and drug-metabolizing enzymes (DMEs), in vivo animal models and in vitro 2D plastic dishes are not good DIH models. The aim of this study was to evaluate whether 3D re-cellularized liver is a sensitive, accurate and efficient DIH model for evaluation of hepatoprotectants. Methods: 2D plastic dishes and 3D decellular liver scaffolds were perfused with HepG2 cells or augmenter of liver regeneration (ALR)-HepG2 cells. These two cell lines were exposed to 4 μM troglitazone (TRO) or 20 μM diclofenac sodium (DIC) on day 8. DME-related genes were analyzed by quantitative reverse transcription polymerase chain reaction; morphological images were revealed by immunohistochemistry, scanning electron microscopy, transmission electron microscopy, and hematoxylin and eosin staining. Results: DME activity and cell polarity were retained and lower doses of TRO and DIC led to DIH in 3D re-cellularized liver. This DIH model reflected the protective effects and mechanism of ALR, which is one of the hepatoprotectants. ALR reduced mitochondrial damage, decreased transaminase level, and alleviated inflammation in TRO-DIH and DIC-DIH. Our re-cellularized liver lobe also showed the effect of ALR in suppressing expression of DMEs. Conclusions: Drug-induced 3D re-cellularized tissue engineering is a sensitive, accurate, and efficient DIH model for evaluation of hepatoprotectants.
Myocardial fibrosis, inflammation, and altered cardiac gene expression profiles in rats exposed to a predator-based model of posttraumatic stress disorder

Abstract People who are exposed to life-threatening trauma are at risk of developing posttraumatic stress disorder (PTSD). In addition to psychological manifestations, PTSD is associated with an increased risk of myocardial infarction, arrhythmias, hypertension, and other cardiovascular problems. We previously reported that rats exposed to a predator-based model of PTSD develop myocardial hypersensitivity to ischemic injury. This study characterized cardiac changes in histology and gene expression in rats exposed this model. Male rats were subjected to two cat exposures (separated by a period of 10 d) and daily cage-mate changes for 31 d. Control rats were not exposed to the cat or cage-mate changes. Ventricular tissue was analyzed by RNA sequencing, western blotting, histology, and immunohistochemistry. Multifocal lesions characterized by necrosis, mononuclear cell infiltration, and collagen deposition were observed in hearts from all stressed rats but none of the control rats. Gene expression analysis identified clusters of upregulated genes associated with endothelial to mesenchymal transition, endothelial migration, mesenchyme differentiation, and extracellular matrix remodeling in hearts from stressed rats. Consistent with endothelial to mesenchymal transition, rats from stressed hearts exhibited increased expression of α-smooth muscle actin (a myofibroblast marker) and a decrease in the number of CD31 positive endothelial cells. These data provide evidence that predator-based stress induces myocardial lesions and reprograming of cardiac gene expression. These changes may underlie the myocardial hypersensitivity to ischemia observed in these animals. This rat model may provide a useful tool for investigating the cardiac impact of PTSD and other forms of chronic psychological stress. Lay summary Chronic predator stress induces the formation of myocardial lesions characterized by necrosis, collagen deposition, and mononuclear cell infiltration. This is accompanied by changes in gene expression and histology that are indicative of cardiac remodeling. These changes may underlie the increased risk of arrhythmias, myocardial infarction, and other cardiac pathologies in people who have PTSD or other forms of chronic stress.
Crowdsourcing lexical semantic judgements from bilingual dictionary users

Words can take on many meanings, and collecting and identifying example usages representative of the full variety of meanings words can take is a bottleneck to the study of lexical semantics using statistical approaches. To perform supervised word sense disambiguation (WSD), or to evaluate knowledge-based methods, a corpus of texts annotated with senses from a dictionary may be constructed by paid experts. However, the cost usually prohibits more than a small sample of words and senses being represented in the corpus. Crowdsourcing methods promise to acquire data more cheaply, albeit with a greater challenge for quality control. Most crowdsourcing to date has incentivised participation in the form of a payment or by gamification of the resource construction task. However, with paid crowdsourcing the cost of human labour scales linearly with the output size, and while game playing volunteers may be free, gamification studies must compete with a multi-billion dollar games industry for players. In this thesis we develop and evaluate resources for computational semantics, working towards a crowdsourcing method that extracts information from naturally occurring human activities. A number of software products exist for glossing Japanese text with entries from a dictionary for English speaking students. However, the most popular ones have a tendency to either present an overwhelming amount of information containing every sense of every word or else hide too much information and risk removing senses with particular relevance to a specific text. By offering a glossing application with interactive features for exploring word senses, we create an opportunity to crowdsource human judgements about word senses and record human interaction with semantic NLP. Declaration This is to certify that: (i) the thesis comprises only my original work towards the PhD except where indicated in the Preface; (ii) due acknowledgement has been made in the text to all other material used; (iii) the thesis is fewer than 100,000 words in length, exclusive of tables, maps, bibliographies and appendices.
Improving Network Performance Through Endpoint Diagnosis and Multipath Communications

IMPROVING NETWORK PERFORMANCE THROUGH ENDPOINT DIAGNOSIS AND MULTIPATH COMMUNICATIONS Behnaz Arzani Boon Thau Loo Roch Guerin Components of networks, and by extension the internet can fail. It is, therefore, important to find the points of failure and resolve existing issues as quickly as possible. Resolution, however, takes time and its important to maintain high quality of service (QoS) for existing clients while it is in progress. In this work, our goal is to provide clients with means of avoiding failures if/when possible to maintain high QoS while enabling them to assist in the diagnosis process to speed up the time to recovery. Fixing failures relies on first detecting that there is one and then identifying where it occurred so as to be able to remedy it. We take a two-step approach in our solution. First, we identify the entity (Client, Server, Network) responsible for the failure. Next, if a failure is identified as network related additional algorithms are triggered to detect the device responsible. To achieve the first step, we revisit the question: how much can you infer about a failure using TCP statistics collected at one of the endpoints in a connection? Using an agent that captures TCP statistics at one of the end points we devise a classification algorithm that identifies the root cause of failures. Using insights derived from this classification algorithm we identify dominant TCP metrics that indicate where/why problems occur. If/when a failure is identified as a network related problem, the second step is triggered, where the algorithm uses additional information that is collected from “failed” connections to identify the device which resulted in the failure. vi Failures are also disruptive to user’s performance. Resolution may take time. Therefore, it is important to be able to shield clients from their effects as much as possible. One option for avoiding problems resulting from failures is to rely on multiple paths (they are unlikely to go bad at the same time). The use of multiple paths involves both selecting paths (routing) and using them effectively. The second part of this thesis explores the efficacy of multipath communication in such situations. It is expected that multi-path communications have monetary implications for the ISP’s and content providers. Our solution, therefore, aims to minimize such costs to the content providers while significantly improving user performance.
Investigating the Adequacy of Response Time Outlier Definitions in Computer-Based Web Surveys Using Paradata SurveyFocus

Web surveys are commonly used in social research because they are usually cheaper, faster, and simpler to conduct than other modes. They also enable researchers to capture paradata such as response times. Particularly, the determination of proper values to define outliers in response time analyses has proven to be an intricate challenge. In fact, to a certain degree, researchers determine them arbitrarily. In this study, we use “SurveyFocus (SF)”—a paradata tool that records the activity of the web-survey pages—to assess outlier definitions based on response time distributions. Our analyses reveal that these common procedures provide relatively sufficient results. However, they are unable to detect all respondents who temporarily leave the survey, causing bias in the response times. Therefore, we recommend a two-step procedure consisting of the utilization of SF and a common outlier definition to attain a more appropriate analysis and interpretation of response times.
Relationship between prenatal and postnatal conditions and accelerated postnatal growth. Impact on the rigidity of the arterial wall and obesity in childhood

Abstract Restricted growth in utero and accelerated postnatal growth (APG) in the postnatal period have been associated with the development of overweight, obesity and an increased cardiovascular risk in childhood. The objectives of this study were to evaluate the influence of prenatal and perinatal conditions on APG and to evaluate the influence of this APG on different cardiovascular risk factors such as body mass index (BMI), body fat mass index (FMI), blood pressure (BP) and arterial wall stiffness [carotid to femoral pulse wave velocity (cf-PWV)]. All measurements were performed in 355 children (185 boys and 170 girls; 8–11 years). Data on mother weight before and during pregnancy, gestational age (weeks), birth weight (g) and breastfeeding of children were obtained through interviews with families. Children who presented APG were born of mothers with lower BMIs before pregnancy and who gained less weight during the second trimester of pregnancy. They also have a lower gestational age and birth weight, a shorter duration of breastfeeding and a longer duration of artificial feeding (AF). Later in childhood, they had higher values of cf-PWV, BMI, FMI and higher prevalence of hypertension. Low maternal gestational weight gain, inadequate fetal development (low birth weight, shorter gestational age) and reduced breastfeeding duration favor APG. Infants with such APG had higher values of cf-PWV, BP, BMI and FMI later in childhood, along with a higher risk of hypertension and obesity. The interaction between APG and a longer duration of AF had a negative effect on cf-PWV (arterial stiffness) and FMI.
Patterns and Correlates of Knowledge, Communication, and Receipt of Breast Reconstruction in a Modern Population-Based Cohort of Patients with Breast Cancer.

BACKGROUND Disparities persist in the receipt of breast reconstruction after mastectomy, and little is known about the nature of communication received by patients and potential variations that may exist. METHODS Women with early-stage breast cancer (stages 0 to II) diagnosed between July of 2013 and September of 2014 were identified through the Georgia and Los Angeles Surveillance, Epidemiology, and End Results registries and surveyed to collect additional data on demographics, treatment, and decision-making experiences. Treating general/oncologic surgeons were also surveyed. Primary outcomes measures included self-reported communication-related measures on receipt of information on breast reconstruction and on the receipt of breast reconstruction. RESULTS The authors analyzed 936 women who underwent mastectomy for unilateral breast cancer. Four hundred eighty-four (51.7 percent) underwent mastectomy with reconstruction. Women who were older and for whom English was not their primary spoken language had lower odds of being informed by a doctor about breast reconstruction. Ultimately, women who were older, were Asian, had invasive disease, had bronchitis/emphysema, and had lower income were less likely to undergo breast reconstruction. Breast reconstruction was performed more often in patients undergoing bilateral mastectomies (OR, 3.27; 95 percent CI, 2.26 to 4.75). Women cared for by surgeons with higher volumes of breast cancer patients (≥51 patients per year) were more likely to undergo breast reconstruction (OR, 2.43; 95 percent CI, 1.40 to 4.20). CONCLUSION To eliminate existing disparities, increased efforts should be made in consultations for surgical management of breast cancer to provide information to all patients regarding the option of breast reconstruction, the possibility of immediate reconstruction, and insurance coverage of all stages of reconstruction.
Two novel GJA1 variants in oculodentodigital dysplasia

Oculodentodigital dysplasia (ODDD) is a rare disorder with pleiotropic effects involving multiple body systems, caused by mutations in the gap junction protein alpha 1 (GJA1) gene. GJA1 gene encodes a polytopic connexin membrane protein, Cx43, that is a component of connexon membrane channels.
Children’s Coping and Perceptions of Coping Efficacy After Sexual Abuse: Links to Trauma Symptoms

Despite an emphasis on coping following childhood sexual abuse (CSA) to reduce trauma-related symptoms, very few studies have researched the associations between sexually abused children’s coping and trauma-related difficulties, and perceived coping efficacy has been largely overlooked. The current study investigated whether children’s use and perceived efficacy of avoidant, internalized, angry, and active/social coping strategies were associated with caregiver- and child-reported posttraumatic stress symptoms (PTSS), and caregiver-reported internalizing and externalizing symptoms among 202 sexually abused children (8-12 years; M = 10.47 years, SD = 1.70 years). Children reported using approximately eight types of coping strategies (M = 8.29, SD =2.50). Regression models indicated that internalized and angry coping were associated with child-reported PTSS. In contrast to expectations, none of the types of coping strategies were linked with caregiver’s reports of PTSS or internalizing and externalizing symptoms. Interestingly, perceived efficacy of coping was largely unrelated to symptoms, with only perceived efficacy of avoidant coping inversely related to child-reported PTSS. Perceived efficacy was not tied to caregiver’s reports of children’s symptoms. Coping strategies may be associated with children’s, but not caregiver’s, reports of children’s trauma-related difficulties. Furthermore, perceived efficacy of coping strategies may also be largely unrelated to children’s symptoms, or children may have limited insight regarding the efficacy of their coping strategies. To further inform trauma-focused interventions that support effective long-term coping, future research should investigate which coping strategies children perceive to be efficacious, as well as potential reasons why.
Research on Personalized Recommendation Method of Academic Resources based on Hadoop

Facing the huge amount of academic resources, it is difficult for users to find the needed resources accurately through keyword search. On the basis of collaborative filtering, a personalized recommendation method for academic resources is proposed by fusing user attributes, academic resource attributes, and users' scores on academic resources, effectively alleviate the scarcity of scoring and cold start problems, improve the accuracy of the recommended method. Combined with the advantages of Hadoop distributed computing, design and implementation the highly effective academic resources personalized recommendation method which based Hadoop, the validity and of the design are proved by experiments.
A rare case report

Rationale:Neuroblastoma is one of the most common malignant tumors in childhood, which mainly occurs in adrenal glands and peripheral sympathetic nerve system. Neuroblastoma occurring in adulthood is rare, and adults with neuroblastoma arising from thorax are exceedingly rare. A case of neuroblastoma that originated from thorax was reported, and was treated by resection operation. Patient concerns: A 46-year-old woman was admitted to our hospital with left side chest pain for 5 days. Laboratory examinations were all normal. Chest computerized tomogram (CT) showed a lesion with clear boundary that was located at the left dorsal pleura. The nature of the mass was heterogeneous, showing slight heterogeneous enhancement after contrast and there was no obvious necrosis. Diagnoses:Based on the morphologic and immunohistochemical features, the tumor diagnosis was favorable for neuroblastoma. Interventions: A resection operation was carried out. Outcomes: Three years postoperative, no sign of recurrence or metastasis has been observed. Lessons: Primary neuroblastoma in adulthood is rare and has poor prognosis. Resection can be an important treatment option, and combining with other methods like chemotherapy, stem cell transplantation, the survival rate may be improved. Abbreviations: CT = computerized tomogram, HIV = human immunodeficiency virus, Hu =Hounsfield Unit, INRG= International Neuroblastoma Risk Group.
Identification of Down-Regulated Proteome in Saccharomyces cerevisiae with the Deletion of Yeast Cathepsin D in Response to Nitrogen Stress

Vacuolar proteinase A (Pep4p) is required for the post-translational precursor maturation of vacuolar proteinases in Saccharomyces cerevisiae, and important for protein turnover after oxidative damage. The presence of proteinase A in brewing yeast leads to the decline of beer foam stability, thus the deletion or inhibition of Pep4p is generally used. However, the influence of Pep4p deletion on cell metabolism in Saccharomyces cerevisiae is still unclear. Herein, we report the identification of differentially down-regulated metabolic proteins in the absence of Pep4p by a comparative proteomics approach. 2D-PAGE (two-dimensional polyacrylamide gel electrophoresis) presented that the number of significantly up-regulated spots (the Pep4p-deficient species versus the wild type) was 183, whereas the down-regulated spots numbered 111. Among them, 35 identified proteins were differentially down-regulated more than 10-fold in the Pep4p-deficient compared to the wild-type species. The data revealed that Pep4p was required for the synthesis and maturation of several glycolytic enzymes and stress proteins, including Eno2p, Fba1p, Pdc1p, Tpi1p, Ssa1, Hsp82p, and Trr1p. The transcription and post-translational modifications of glycolytic enzymes like Eno2p and Fba1p were sensitive to the absence of Pep4p; whereas the depletion of the pep4 gene had a negative impact on mitochondrial and other physiological functions. The finding of this study provides a systematic understanding that Pep4p may serve as a regulating factor for cell physiology and metabolic processes in S. cerevisiae under a nitrogen stress environment.