Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Enriching Honey with Propolis on the Antioxidant Activity, Sensory Characteristics, and Quality Parameters

Bee products, including propolis, are a valuable source of biologically active substances. The most natural way to introduce propolis in the diet seems to be its addition to honey. The aim of this study was to analyze the effect of honey enrichment with propolis on the content of selected bioactive compounds, antioxidant potential, as well as sensory and qualitative characteristics of honey. On the basis of the obtained results, it was stated that the addition of propolis extract to honey contributed to a significant increase in the content of polyphenolic compounds, including flavonoids and phenolic acids, among which chrysin, pinocembrin, p-coumaric, and ferulic acid reached the highest level. The increase of antioxidant, antiradical, and reduction in activity of enriched honey was observed as a result of increasing addition of propolis extract. However, the enrichment of honey with propolis contributed to deterioration of the sensory properties. The changes in color, smell, texture, and taste were observed. The addition of propolis to honey had no significant effect on 5-hydroxymethylfurfural (HMF) and sugar content, and specific conductivity. On the other hand, a significant increase in free acidity and content of substances insoluble in water was observed. The obtained results indicate that honey supplemented with propolis extract can be an excellent source of antioxidant compounds, nevertheless, the amount of additive used is strongly dependent on changes in sensory characteristics and consumer acceptability.
Leg stiffness control during drop landing movement in individuals with mechanical and functional ankle disabilities

ABSTRACT Purpose: Individuals with mechanical ankle instability (MAI) and functional ankle instability (FAI) present with residual movement dysfunctions after an initial lateral ankle sprain. This study investigated leg stiffness control to determine how behavioural characteristics between MAI and FAI differ during single-leg drop landing movement. Methods: Thirty individuals (10 with MAI, 10 with FAI, and 10 healthy controls) participated in this study. During single-leg drop landing movement, we estimated dimensionless leg stiffness, peak vertical force (PVF), change in the displacement of leg movement, loading rate, angular joint movement, and internal joint moment for impaired and unimpaired legs, respectively. Univariate one-way analysis of variance was used for each dependent variable across leg conditions. Results: The MAI group had lower dimensionless leg stiffness with greater change in the displacement of leg movement for the impaired leg than the FAI and control groups. Moreover, reduced leg stiffness was associated with greater hip joint flexion movement in the MAI group, whereas ankle dorsiflexion movement increased to decrease the leg stiffness in the FAI and control groups. Conclusion: These findings indicate that lower leg stiffness in the MAI group than in the FAI group may be attributed to compensatory actions to minimise reliance on their ankle movement after landing.
The heme-regulatory motifs of heme oxygenase-2 contribute to the transfer of heme to the catalytic site for degradation

Heme-regulatory motifs (HRMs) are present in many proteins that are involved in diverse biological functions. The C-terminal tail region of human heme oxygenase-2 (HO2) contains two HRMs whose cysteine residues form a disulfide bond; when reduced, these cysteines are available to bind Fe3+-heme. Heme binding to the HRMs occurs independently of the HO2 catalytic active site in the core of the protein, where heme binds with high affinity and is degraded to biliverdin. Here, we describe the reversible, protein-mediated transfer of heme between the HRMs and the HO2 core. Using hydrogen-deuterium exchange (HDX)-MS to monitor the dynamics of HO2 with and without Fe3+-heme bound to the HRMs and to the core, we detected conformational changes in the catalytic core only in one state of the catalytic cycle—when Fe3+-heme is bound to the HRMs and the core is in the apo state. These conformational changes were consistent with transfer of heme between binding sites. Indeed, we observed that HRM-bound Fe3+-heme is transferred to the apo-core either upon independent expression of the core and of a construct spanning the HRM-containing tail or after a single turnover of heme at the core. Moreover, we observed transfer of heme from the core to the HRMs and equilibration of heme between the core and HRMs. We therefore propose an Fe3+-heme transfer model in which HRM-bound heme is readily transferred to the catalytic site for degradation to facilitate turnover but can also equilibrate between the sites to maintain heme homeostasis.
Effects of high relative humidity and dry purging on VOCs obtained during breath sampling on common sorbent tubes

Offline breath analysis by thermal desorption gas chromatography mass spectrometry (TD-GC-MS) requires the use of sorbent traps to concentrate and store volatile compounds. The selection of which sorbent to use and best practices for managing high relative humidity are important considerations to allow for reproducible, untargeted, biomarker discovery in water saturated breath samples. This work aims to assess three commonly used sorbent materials for their use in breath volatile sampling and determine how the high relative humidity inherent in such samples effects the capture of volatile compounds of interest. TenaxGR, TenaxTA/Carbograph1TD and TenaxTA/Carbograph5TD tubes were selected as they are the most commonly used sorbents in the breath sampling literature. The recovery of 29 compounds in a standard mix loaded using high humidity gas was tested for each sorbent and compared to loading in dry gas. Water retention and dry purge rates were determined for each sorbent for 500 ml and 1000 ml breath collections. Finally, breath samples were collected simultaneously on to each sorbent type using the ReCIVA and analysed by TD-GC-MS. All three sorbents exhibited acceptable reproducibility when loaded with the standard mix in dry gas (RSD < 10%). Loading the standard mix in humid gas led to reduced recovery of compounds based on their chemical properties. Dry purging performance for each sorbent material was assessed and was shown to be 1.14, 1.13 and 0.89 mg H2O min−1 for TenaxGR, TenaxTA/Carbograph1TD and TenaxTA/Carbograph5TD respectively when flushed with 50 ml min−1 of N2. A comparison of breath profiles on different sorbents showed differences in background artefacts (sulfur dioxide, cyclopenten-1-one and 3-nonene) and endogenous breath compounds (2-methyl-furan and furfural). This work demonstrates that high relative humidity during sampling reduces the ability of sorbent tubes to capture volatile compounds and could impact method detection limits during breath sampling. Sufficient water to impair accurate analysis was retained on all tubes. Minimal differences were observed between sorbent materials when used to sample breath, however, suggestions are provided for sorbent selection for future studies.
Using intelligent interaction to manage student–supervisor conflict: A qualitative study

INTRODUCTION: Student–supervisor conflict is inevitable in an academic setting. The purpose of the present study aimed to argue that using intelligent interaction as an appropriate strategy to manage the student–supervisor conflict in Iranian nursing schools. MATERIALS AND METHODS: This qualitative study was a part of larger grounded theory research. Data were collected by conducting a semi-structured interview with nine nursing students and five supervisors who were selected by purposeful sampling in the current investigation. Data analysis was done through the recommended method of Corbin and Strauss (2015). RESULTS: Intelligent interaction was extracted as one of the main categories for managing student–supervisor conflict. Intelligent interaction consisted of four subcategories including use a logic strategy, competent role play, flexible and smart selection, and getting help from other sources. CONCLUSION: Intelligent interaction is an appropriate strategy to resolve and manage the supervisor–student conflict in the Iranian academic setting. It is suggested that universities must consider intelligent interaction in developing a policy-procedure process for managing the student–supervisor conflict in Iranian academic settings.
Loss of melusin is a novel, neuronal NO synthase/FoxO3‐independent master switch of unloading‐induced muscle atrophy

Unloading/disuse induces skeletal muscle atrophy in bedridden patients and aged people, who cannot prevent it by means of exercise. Because interventions against known atrophy initiators, such as oxidative stress and neuronal NO synthase (nNOS) redistribution, are only partially effective, we investigated the involvement of melusin, a muscle‐specific integrin‐associated protein and a recognized regulator of protein kinases and mechanotransduction in cardiomyocytes.
Evaluation of word recognition and word recall with bone conduction devices: do directional microphones free up cognitive resources?

Abstract Objective: To determine if directional microphones improve cognitive capacity in typically hearing adults. The study objectives are to evaluate differences in (1) speech recognition and (2) working memory through a word recall task between bilateral directional and omnidirectional microphone settings. Design: A conductive hearing loss was artificially induced while participants wore bilateral bone conduction hearing aids on softbands. For each hearing aid setting (bilateral omnidirectional and bilateral directional), seven blocks of seven sentences from the Hearing in Noise Test (HINT) were presented at a signal-to-noise ratio of +2 dB. Participants repeated each sentence aloud and after each block, wrote down as many of the last words as they could recall. Study sample: Thirty-five typical hearing adults and a subset (n = 20) achieving ≥80% recognition. Results: The directional microphone setting showed significant improvement over the omnidirectional setting for recognition and recall for both the full set of participants and the subset of participants with ≥ 80% recognition. Conclusions: This study demonstrated that features such as directional microphones can improve both speech recognition and working memory. Even in listening situations where participants can understand the majority of speech, directional microphones may offer improvements to cognitive capacity and reduce listening effort.
The Association Between Sedentary Behavior and Sarcopenia Among Adults Aged ≥65 Years in Low- and Middle-Income Countries

The present study aimed to assess the association between sedentary behavior and sarcopenia among adults aged ≥65 years. Cross-sectional data from the Study on Global Ageing and Adult Health were analyzed. Sarcopenia was defined as having low skeletal muscle mass and either a slow gait speed or a weak handgrip strength. Self-reported sedentary behavior was assessed as a continuous variable (hours per day) and also as a categorical variable (0–<4, 4–<8, 8–<11, ≥11 hours/day). Multivariable logistic regression was conducted to assess the association between sedentary behavior and sarcopenia. Analyses using the overall sample and country-wise samples were conducted. A total of 14,585 participants aged ≥65 years were included in the analysis. Their mean age was 72.6 (standard deviation, 11.5) years and 55% were females. Compared to sedentary behavior of 0–<4 hours/day, ≥11 hours/day was significantly associated with 2.14 (95% CI = 1.06–4.33) times higher odds for sarcopenia. The country-wise analysis showed that overall, a one-hour increase in sedentary behavior per day was associated with 1.06 (95% CI = 1.04–1.10) times higher odds for sarcopenia, while the level of between-country heterogeneity was low (I2 = 12.9%). Public health and healthcare practitioners may wish to target reductions in sedentary behavior to aid in the prevention of sarcopenia in older adults.
The Distribution of Furfuryl Alcohol (FA) Resin in Bamboo Materials after Surface Furfurylation

In this study, bamboo was treated with an optimized surface furfurylation process. With this process, dimensionally stable and highly biologically durable bamboo material could be prepared without mechanical reduction. The anti-swelling efficiency (ASE) could reach 50% with a low weight percent gain (WPG about 13%). By using SEM, nanoindentation, and Imaging FTIR, we demonstrated that this high performance improvement is attributed to the unique furfuryl alcohol (FA) resin distribution pattern in the modified bamboo, namely a higher concentration of FA resin located in the region near to the surface of bamboo, and what is more, the preferred distribution of FA resin within the cell walls of parenchyma cells, which is known to be the weak point of bamboo both for biological durability and mechanical performances. Such graded modified bamboo could be utilized as a reliable engineering material for outdoor applications.
Recent Advances in Encapsulation, Protection, and Oral Delivery of Bioactive Proteins and Peptides using Colloidal Systems

There are many areas in medicine and industry where it would be advantageous to orally deliver bioactive proteins and peptides (BPPs), including ACE inhibitors, antimicrobials, antioxidants, hormones, enzymes, and vaccines. A major challenge in this area is that many BPPs degrade during storage of the product or during passage through the human gut, thereby losing their activity. Moreover, many BPPs have undesirable taste profiles (such as bitterness or astringency), which makes them unpleasant to consume. These challenges can often be overcome by encapsulating them within colloidal particles that protect them from any adverse conditions in their environment, but then release them at the desired site-of-action, which may be inside the gut or body. This article begins with a discussion of BPP characteristics and the hurdles involved in their delivery. It then highlights the characteristics of colloidal particles that can be manipulated to create effective BPP-delivery systems, including particle composition, size, and interfacial properties. The factors impacting the functional performance of colloidal delivery systems are then highlighted, including their loading capacity, encapsulation efficiency, protective properties, retention/release properties, and stability. Different kinds of colloidal delivery systems suitable for encapsulation of BPPs are then reviewed, such as microemulsions, emulsions, solid lipid particles, liposomes, and microgels. Finally, some examples of the use of colloidal delivery systems for delivery of specific BPPs are given, including hormones, enzymes, vaccines, antimicrobials, and ACE inhibitors. An emphasis is on the development of food-grade colloidal delivery systems, which could be used in functional or medical food applications. The knowledge presented should facilitate the design of more effective vehicles for the oral delivery of bioactive proteins and peptides.
From 'neurotic' to 'managing' mother: The 'medical career' experienced by mothers of a child diagnosed with Juvenile Idiopathic Arthritis.

Objective Despite increased research into how caring for a child diagnosed with juvenile idiopathic arthritis (JIA) affects mothers, more needs to be known about ways in which such experiences transform their lives. Insight into the experiences of such mothers was sought through analysis of interviews with eight mothers and one father caring for a child with JIA. Design The study is situated within a larger project involving families with a child with JIA. A social constructionist approach was adopted and grounded theory including a 'negative case,' guided gathering and analysing data. Individual, semi-structured interviews were conducted based on the research question: 'What is it like to be the mother of a child with juvenile idiopathic arthritis? ' Results Findings suggest that mothers find difficulty living up to the 'ideal mother' expected within Western society when forced to provide competing demands of age-related, yet illness-relevant care. The unpredictable nature of JIA means mothers face a lack of understanding from professionals so become hyper-vigilant, 'battling' on behalf of their ill child. A self-perpetuating loop develops if this is misperceived as being overprotective, leaving mothers vulnerable to being judged 'neurotic'. However, with experience, often at an emotional cost, such mothers' confidence in managing the competing demands of caring for their ill child increases such they can navigate a positive journey from 'neurotic' to 'managing' mother. Conclusions Understanding this process could help health care professionals reduce stressful experiences faced by mothers when caring for a chronically ill child. Statement of contribution What is already known on this subject? Mothers of chronically ill children are often diagnosed with anxiety and depression. Such mothers will have taken over managing their child's condition, and this can include negative experiences within the health care system. Qualitative methods enable deeper understanding of the experiences of mothers of chronically ill children. What does the study add? Potentially gendered position of mothers of children with chronic conditions. Taken for granted assumptions implicitly underpin interactions between mothers and some professionals. Greater partnership between mothers and professionals ultimately improves the care of the ill child.
A Survey of Visual Analytics for Public Health

We describe visual analytics solutions aiming to support public health professionals, and thus, preventive measures. Prevention aims at advocating behaviour and policy changes likely to improve human health. Public health strives to limit the outbreak of acute diseases as well as the reduction of chronic diseases and injuries. For this purpose, data are collected to identify trends in human health, to derive hypotheses, e.g. related to risk factors, and to get insights in the data and the underlying phenomena. Most public health data have a temporal character. Moreover, the spatial character, e.g. spatial clustering of diseases, needs to be considered for decision‐making. Visual analytics techniques involve (subspace) clustering, interaction techniques to identify relevant subpopulations, e.g. being particularly vulnerable to diseases, imputation of missing values, visual queries as well as visualization and interaction techniques for spatio‐temporal data. We describe requirements, tasks and visual analytics techniques that are widely used in public health before going into detail with respect to applications. These include outbreak surveillance and epidemiology research, e.g. cancer epidemiology. We classify the solutions based on the visual analytics techniques employed. We also discuss gaps in the current state of the art and resulting research opportunities in a research agenda to advance visual analytics support in public health.
Influence of Preformed Antibodies in Liver Transplantation

The significance of human leukocyte antigen (HLA) matching and preformed donor-specific antibodies (DSAs) in liver transplantation remains unclear. The aim of this study was to analyze the presence of DSAs in a large cohort of 810 liver recipients undergoing liver transplant to determine the influence on acute (AR) or chronic liver rejection (CR), graft loss and allograft survival. DSAs were identified using complement dependent cytotoxicity crossmatch (CDC-CM) and multiplexed solid-phase-based flow cytometry assay (Luminex). CDC-CM showed that a 3.2% of liver transplants were positive (+CDC-CM) with an AR frequency of 19.2% which was not different from that observed in negative patients (−CDC-CM, 22.3%). Only two patients transplanted with +CDC-CM (7.6%) developed CR and suffered re-transplant. +CDC-CM patients showed a significantly lower survival rate compared to −CDC-CM patients (23.1% vs. 59.1%, p = 0.0003), developing allograft failure within the first three months (p < 0.00001). In conclusion, we have demonstrated a relationship between the presence of preformed DSAs and the low graft liver survival, indicating the important role and the potential interest of performing this analysis before liver transplantation. Our results could help to detect patients with an increased risk of graft loss, a better choice of liver receptors as well as the establishment of individualized immunosuppressive regimens.
PATIENT PREFERENCES, STRUCTURE, AND HIV ARE ASSOCIATED WITH ADHERENCE TO TUBERCULOSIS TREATMENT IN URBAN UGANDA

xvi 1.0. 0 Chapter one: Introduction . 1 1.0. 1 Overview . 1 1.0. 2 Study conceptual model . 3 1.0. 3 Justification . 6 1.0. 4 Goal . 7 1.0. 5 Specific Aims . 8 1.0. 6 Contributions of this dissertation . 9 2.0. 0 Chapter Two: Literature review . 12 2.0. 1 Importance of Adherence . 12 2.0. 2 Adherence and quality of tuberculosis care . 13 2.0. 3 Measurement of adherence. 15 2.0. 4 Adherence and its Risk factors to Tuberculosis treatment in Uganda and other developing countries . 16 2.0. 5 Impact of HIV sero-status on adherence to tuberculosis treatment . 17