Miracle-dz/UniFAR-FTUs huggingface dataset:
5G Synchronization, Positioning, and Mapping From Diffuse Multipath

5G mmWave communication systems have the potential to jointly estimate the positions of user equipment (UE) and mapping their propagation environments using a single base station. But such potential depends on the characteristics of the reflecting surfaces, such as a deterministic specular nature, a stochastic diffuse/scattering nature, or a combination of both. In this letter, we proposed a 5G positioning and mapping algorithm with unknown orientation and clock bias for single-bounce diffuse multipath channel models. The method is able to accurately localize, calibrate and synchronize the UE, even in the absence of line-of-sight and specular components. This enables robust positioning and mapping using only diffuse multipath.
A comparative study on fatty acid compositions, total phenolic contents, and antioxidant potentials of various extracts from different parts of Euphorbia chamaesyce L.

In this study, fatty acid composition, total phenolic contents, and antioxidant activities of the extracts obtained from the stem and seed parts of Euphorbia chamaesyce L. (Euphorbiaceae) were investigated. Linolenic and linoleic acids were determined as the main fatty acid components in the seed (32.42% and 15.04%, respectively ) and stem (22.31% and 14.25%, respectively ) hexane extracts by using GC/MS. EC/SEM (seed methanolic extract, IC 50 = 5.35 ± 0.01 µg/mL), EC/SEA (seed acetone extract, IC 50 = 8.61 ± 0.11 µg/mL), and EC/SEE (seed ethyl acetate extract; IC 50 = 20.6 ± 1.12 µg/mL) exhibited higher radical scavenging effect than synthetic antioxidant BHT. Also, a positive correlation was found between the total phenolic content and DPPH radical scavenging activity. The results showed that the seeds of this plant had a high amount of polyunsaturated fatty acids and remarkable antioxidant activities.
Standardization and application of immunofluorescence and immuno- peroxidase tests for detection of bluetongue virus antigen

India is enzootic for bluetongue (BT), a predominant disease of small ruminants. The most important task in the control of disease is rapid and sensitive detection of virus. The present study was undertaken to standardize immunofluorescence (IFT) and immunoperoxidase tests (IPT) employing BTV serogroup specific VP7 monoclonal antibodies (MAbs), polyclonal homologous, and polyclonal heterologous antisera against specific serotypes of BTV for detection of BTV antigen. Serial tenfold dilutions of BTV-9 were tested for limit of detection (LoD) of IFT, IPT, and molecular assays by using MAbs against VP7, homologous anti-BTV-9 serum, and heterologous anti-BTV-16 serum. LoD of IFT was found to be 101 TCID50/mL using MAbs against VP7, anti BTV-9 serum, and anti BTV-16 serum. LoD of IPT was found to be 101 TCID50/mL, 102 TCID50/mL, and 102 TCID50/mL using MAbs against VP7, anti BTV-9 serum and anti BTV-16 serum, respectively. LoD of RT-PCR was 101 TCID50/mL and that of real time PCR was 100 TCID50/mL. This standardized assay was then applied for BTV detection in BTV suspected field samples collected from BT outbreaks followed by confirmation with virus isolation and NS3 group specific PCR. The current study shows that IFT and IPT are specific tests for group specific BTV identification. For IFT, monoclonal and polyclonal (homologous and heterologous) source of antibodies had similar sensitivity in the ability of BTV detection; whereas the most sensitive mode of detection by IPT was with MAbs.
Control and Implementation of a Multifunctional Solar PV-BES-DEGS Based Microgrid

A three-phase four-wire microgrid comprising of a solar photovoltaic (PV) array—battery energy storage—a diesel engine generator set (DEGS) is presented in this article. Here an enhanced adaptive filter (EAF) control and an incremental conductance (INC) maximum power point tracking algorithm are used to improve the power quality and to extract the maximum power from the PV array. The EAF control provides higher disturbance rejection capability over other controls. The EAF control is applied to the voltage source converter (VSC) to improve the power quality, such as compensation of harmonics, reactive power, and load unbalance. The INC control is used to harvest the PV array maximum power. For controlling the voltage output of the DEGS, an electronic automatic voltage regulator is provided at the synchronous generator field winding. The neutral current compensation is achieved by controlling the fourth-leg of VSC. This microgrid is simulated using MATLAB/Simulink tool. The robustness of the EAF control strategy is tested on a developed system prototype in the laboratory.
How to Encourage SME Employees to be Innovative? The Role of Attitude, Social Support and Behavioral Intention.

This articles examines how attitude and social support has a positive effect on employeeÂs intention to engage in innovative behavior. The association of antecedents of self-enhancement, openness to change, leader support and organizational support were also examined. Accordingly, this study employed a survey questionnaire and thereafter data has been obtained from 201 employees working in Electrical and Electronic of Small and Medium Enterprises (SMEs). This data has been analyzed using SPSS and PLS-SEM . From the findings, the data showed a positive association between attitude and intention on innovative behavior. The results also indicate a positive relationship between social support and intention on innovative behavior. From the finding, the study on innovative behavior provide insights in helping the SMEs to enhance and encourage their employees to become innovative.
Engineered variants provide new insight into the structural properties important for activity of the highly dynamic, trimeric protein disulfide isomerase, PmScsC

Suppressor of copper sensitivity protein C from Proteus mirabilis (PmScsC) is a homotrimeric disulfide isomerase that plays a role in copper tolerance – a key virulence trait of the uropathogen. Each protomer of the enzyme has an N-terminal trimerisation stem (59 residues) containing a flexible linker (11 residues) connected to a thioredoxin-fold-containing catalytic domain (163 residues). Here, we characterise two PmScsC variants, PmScsCΔN and PmScsCΔLinker. PmScsCΔN, is an N-terminally truncated form of the protomer with two helices of the trimerisation stem removed, generating a protein with dithiol oxidase rather than disulfide isomerase activity. The crystal structure of PmScsCΔN reported here reveals – as expected – a monomer that is structurally similar to the catalytic domain of native PmScsC. The second variant PmScsCΔLinker was designed to remove the 11 amino acid linker and we show that it generates a protein that has neither disulfide isomerase nor dithiol oxidase activity. The crystal structure of PmScsCΔLinker reveals a trimeric arrangement, with the catalytic domains packed together very closely. Small angle X-ray scattering analysis found that native PmScsC is predominantly trimeric in solution even at low concentration, whereas PmScsCΔLinker exists as an equilibrium between monomeric, dimeric and trimeric states, with the monomeric form dominating at low concentrations. These findings increase our understanding of disulfide isomerase activity, showing how (i) oligomerisation, (ii) spacing between, and (iii) dynamic motion of, catalytic domains in PmScsC all contribute to its native function.
A freeze-and-thaw-induced fragment of the microtubule-associated protein tau in rat brain extracts: implications for the biochemical assessment of neurotoxicity

Tau is a microtubule-associated protein responsible for controlling the stabilization of microtubules in neurons. Tau function is regulated by phosphorylation. However, in some neurological diseases Tau becomes aberrantly hyperphosphorylated, which contributes to the pathogenesis of neurological diseases, known as tauopathies. Western blotting (WB) has been widely employed to determine Tau levels in neurological disease models. However, Tau quantification by WB should be interpreted with care, as this approach has been recognized as prone to produce artifactual results if not properly performed. In this study, our goal was to evaluate the influence of a freeze-and-thaw cycle, a common procedure preceding WB, to the integrity of Tau in brain homogenates from rats, 3xTg-AD mice and human samples. Homogenates were prepared in ice-cold RIPA buffer supplemented with protease/phosphatase inhibitors. Immediately after centrifugation, an aliquot of the extracts was analyzed via WB to quantify total and phosphorylated Tau levels. The remaining aliquots were stored for at least 2 weeks at either −20°C or −80°C and then subjected to WB. Extracts from rodent brains submitted to freeze-and-thaw presented a ~25 kDa fragment immunoreactive to anti-Tau antibodies. An in-gel digestion followed by mass spectrometry analysis in excised bands revealed this ~25 kDa species corresponds to a Tau fragment. Freeze-and-thaw-induced Tau proteolysis was detected even when extracts were stored at −80°C. This phenomenon was not observed in human samples at any storage condition tested. Based on these findings, we strongly recommend the use of fresh extracts of brain samples in molecular analysis of Tau levels in rodents.
Developing Long Time Series 1-km Land Cover Maps From 5-km AVHRR Data Using a Super-Resolution Method

Dynamic land cover (LC) information is an essential part of environmental and ecological research. Therefore, acquiring dynamic LC data with high spatial resolution has attracted a great deal of attention in the remote sensing community. Nevertheless, the high-temporal resolution satellite data tend to have a coarse spatial resolution, and satellite data with high temporal resolution are often relatively low. Obtaining LC with high spatiotemporal resolution is extremely challenging. The super-resolution method can help researchers achieve this goal, and the recently developed neural-network-based deep learning algorithms have great potential for use as an alternative solution. This study proposes a focal loss temporal convolutional long short-term memory (FL-T-ConvLSTM) model for super-resolution LC classification research. It first trains the deep FL-T-ConvLSTM network to establish a transformation between low-resolution quantitative remote sensing parameters and high-resolution quantitative remote sensing parameters and then engages in nonlinear mapping with a high-resolution LC map. A long-term series 1-km super-resolution LC classification model based on deep learning was established and applied to the Beijing–Tianjin–Hebei region. Based on this method, a long-term series of 1-km LC maps from 1982 to 2019 can be obtained. The test accuracy and field validation accuracy of the model reached 90.1% and 86.8% when using reliable test samples and field test samples, respectively. This study provides a method for obtaining high-resolution LC classification products from low-resolution quantitative remote-sensing products.
Dissection of the cellular function of the ZBED6 transcription factor in mouse myoblast cells using gene editing, RNAseq and proteomics

The transcription factor ZBED6 acts as a repressor of Igf2 and affects directly or indirectly the transcriptional regulation of thousands of genes. Here, we use gene editing in mouse C2C12 myoblasts and show that ZBED6 regulates Igf2 exclusively through its binding site 5′-GGCTCG-3′ in intron 1 of Igf2. Deletion of this motif (Igf2ΔGGCT) or complete ablation of Zbed6 leads to ~20-fold up-regulation of IGF2 protein. Quantitative proteomics revealed an activation of Ras signaling pathway in both Zbed6-/- and Igf2ΔGGCT myoblasts, and a significant enrichment of mitochondrial membrane proteins among proteins showing altered expression in Zbed6-/- myoblasts. Both Zbed6-/- and Igf2ΔGGCT myoblasts showed a faster growth rate and developed myotube hypertrophy. These cells exhibited an increased O2 consumption rate, due to IGF2 up-regulation. Transcriptome analysis revealed ~30% overlap between differentially expressed genes in Zbed6-/- and Igf2ΔGGCT myotubes, with an enrichment of up-regulated genes involved in muscle development. In contrast, ZBED6-overexpression in myoblasts led to cell apoptosis, cell cycle arrest, reduced mitochondrial activities and ceased myoblast differentiation. The similarities in growth and differentiation phenotypes observed in Zbed6-/- and Igf2ΔGGCT myoblasts demonstrates that ZBED6 affects mitochondrial activity and myogenesis largely through its regulation of IGF2 expression. This study suggests that the interaction between ZBED6-Igf2 may be a therapeutic target for human diseases where anabolism is impaired.
Nonsense-Mediated mRNA Decay and Ubiquitin–Proteasome System Regulate Cardiac Myosin-Binding Protein C Mutant Levels in Cardiomyopathic Mice

Rationale: Mutations in the MYBPC3 gene encoding cardiac myosin-binding protein (cMyBP)-C are frequent causes of hypertrophic cardiomyopathy, but the mechanisms leading from mutations to disease remain elusive. Objective: The goal of the present study was therefore to gain insights into the mechanisms controlling the expression of MYBPC3 mutations. Methods and Results: We developed a cMyBP-C knock-in mouse carrying a point mutation. The level of total cMyBP-C mRNAs was 50% and 80% lower in heterozygotes and homozygotes, respectively. Surprisingly, the single G>A transition on the last nucleotide of exon 6 resulted in 3 different mutant mRNAs: missense (exchange of G for A), nonsense (exon skipping, frameshift, and premature stop codon) and deletion/insertion (as nonsense but with additional partial retention of downstream intron, restoring of the reading frame, and almost full-length protein). Inhibition of nonsense-mediated mRNA decay in cultured cardiac myocytes or in vivo with emetine or cycloheximide .
RESEARCH OF METHODS OF INACTIVATION OF THE ANTIBIOTIC CYPROFLOXACIN IN ORDER TO PREVENT ENVIRONMENTAL POLLUTION AND PROTECT HUMAN HEALTH

physics and technology experimental studies aimed at inactivation of bactericidal properties of antibiotic solution during processing ozone-air mixture. The study assessed the effectiveness of inactivation of antibiotic ciprofloxacin hydrochloride by methods related to deep oxidation AOPs technologies (Advanced Oxidation Processes) on the basis of combinations of ozonation, UV irradiation, treatment with hydrogen peroxide. Shown the prospects of using ozonation and O 3 /UV and O 3 /UV/H 2 O 2 to reduce the toxic effect of the antibiotic residues of ciprofloxacin relative to the test object E. coli in the aquatic environment. Found that ozonation of activated sludge treated with ciprofloxacin, reduces the toxic effect of the antibiotic and promotes the enzymatic activity of the biocenosis of activated sludge.
Análise de Amostras Sintéticas de Sinais de Sonar Passivo Geradas por Redes Neurais Generativas Adversariais

—In naval warfare, several techniques have been developed for the detection and classiﬁcation of war vessels. Given the conﬁdential nature of the data it is extremely difﬁcult to get a hold of large quantities of data which makes it extremely hard to use techniques that rely on abundant data, such as deep learning. This paper proposes the use of generative adversarial neural networks for the generation of synthetic samples that can later be used in training of classiﬁers. This paper focuses on the generation process and the qualifying of such samples.
Pengaruh Penggunaan Model Pembelajaran Cooperative Tipe Concept Sentence Terhadap Keterampilan Menulis Puisi

Penelitian ini bertujuan untuk, 1. Mengetahui keterampilan menulis puisi sebelum menggunakan model pembelajaran cooperative tipe concept sentence, 2. Mengetahui keterampilan menulis puisi sesudah menggunakan model pembelajaran cooperative tipe concept sentence, 3. Melihat pengaruh penggunaan model pembelajaran cooperative tipe concept sentence terhadap keterampilan menulis puisi pada siswa kelas VIII D SMP Negeri 20 Singkawang tahun ajaran 2016/2017. Penelitian ini menggunakan metode penelitian eksperimen, menggunakan bentuk Pre Exprimental Design, dan pada penelitian ini digunakan rancangan One-Group Pretest-Posstest Design. Populasi dalam penelitian ini adalah seluruh siswa kelas VIII SMP Negeri 20 Singkawang. Dalam penelitian ini sampel yang diambil menggunakan teknik Purposive Sampling. Penelitian pada tahap pertama atau pretest memperoleh mean sebebsar 68,56. Penelitian pada tahap kedua atau posstest memperoleh mean sebebsar 85,72, hasil mean yang diperoleh sangat berbeda dengan hasil mean yang di dapat pada saat tahap pretest. Berdasarkan hasil uji regresi linear dengan bantuan SPSS versi 17 maka jika nilai sig 0,150 (>) 0,05 dapat dikatakan ada hubungan dalam penggunaan model pembelajaran cooperative tipe concept sentence terhadap hasil belajar siswa. Berdasarkan hasil uji t diperoleh nilai Thitung lebih besar dati nilai Ttabel yakni 9,020 > 1,710, hal ini dapat di simpulkan bahwa terdapat hubungan nyata antara hasil belajar sebelum dan sesudah digunakannya model pembelajaran cooperative tipe concept sentence. Dengan diperolehnya hasil uji t tersebut maka hipotesis Ha yang berbunyi pengaruh penggunaan model pembelajaran cooperative tipe concept sentence terhadap hasil belajar menulis puisi diterima.
Language Policy, Prestige, and Stigma: A Case Study of Moroccan Amazigh Language Varieties

Language is a major part of identity in any context, but especially in situations of disenfranchisement and marginalization, in which heritage languages are often subject to repression and resultant shift and loss. One such case of potential loss of linguistic and cultural identity involves the Amazigh language groups in Morocco (and the other Maghreb countries), in the face of past Arabicization efforts in North Africa, the continuing influence of French from the colonial period, and the spread of English as a world language. In this study, I report on the results of a survey that elicited Moroccans’ views regarding the current linguistic landscape of their country, and their predictions for the future. The survey was conducted with two groups, teachers of English in Morocco and members of the Royal Institute of Amazigh Culture or Institut royale de la culture amazighe (IRCAM), a product of the recent and controversial government support for Amazigh identity and issues. Qualitative analysis of the survey openended response questions suggests that both of these groups believe the linguistic landscape of Morocco will remain largely the same, but with a stronger presence of English. While the scale of positive change in Amazigh’s revitalization is slower than hoped for, I conclude tentatively that the issue is entering public consciousness on a broad scale, paving the way for larger scale societal change in favor of Amazigh.
Parental Age and the Risk of Cleft Lip and Palate in a Nigerian Population - A Case–Control Study

Introduction: Orofacial clefts are one of the most common congenital malformations in the facial region. Older maternal or paternal age presents higher odds of a child with an orofacial cleft. The objective of the study was to assess the association between parental age and risk of orofacial cleft. Materials and Methods: This was a case–control study among 110 parents of children with orofacial cleft (case group) and 110 parents of children without orofacial cleft (control group). Information on maternal age, paternal age, and type of orofacial cleft in the children were obtained. The results were analyzed using descriptive statistics, Chi-square analysis, and bivariate logistic regressions to measure the association between parental age and orofacial cleft. The value of P was <0.05, with a 95% confidence interval (CI). Results: Information on 219 children (109 cases and 110 controls) was analyzed, of which 52% were females. One respondent from the case group withdrew from the study. The odds of a child with orofacial cleft was statistically significantly lower in mothers aged 26–35 years compared to mothers aged 25 years and less (odds ratio [OR]: 0.32; 95% CI: 0.16, 0.79). Similarly, fathers aged above 35 years had statistically significantly lower odds of children with orofacial cleft than those 25 years and less (OR: 0.18; 95% CI: 0.02, 0.99). Discussion: Our findings suggest that mothers aged 26-35 years may have lower odds of giving birth to babies with orofacial clefts, compared to younger mothers. Similarly, fathers aged above 35 years may have lower odds of giving birth to a child with orofacial cleft compared to fathers aged 25 years and less.
Modelling Nutrient Requirements of Rainbow Trout and Nile Tilapia Over Their Life Cycle

MODELLING NUTRIENT REQUIREMENTS OF RAINBOW TROUT AND NILE TILAPIA OVER THEIR LIFE CYCLE Evidence suggest that essential nutrient requirements of fish are affected by factors such as live weight and feed composition. Generally, nutrient requirements of fish are estimated through dose-response trials. The considerable variability between these estimates indicates a significant gap in our understanding of nutrient requirements of fish. Application of mathematical models allows quantifying the effect of multiple factors on nutrients requirement while there has been limited efforts to use such approach in fish nutrition. In this thesis, a factorial model was developed to estimate the requirements of an organic (lysine) and an inorganic (phosphorus) nutrient for a carnivorous (rainbow trout) and an omnivorous (Nile tilapia) species through a meta-analysis of data, using a mixed-model approach. In Study 1, maintenance lysine requirements and lysine retention efficiency (LysRE) were estimated through meta-analysis of data from dose-response studies from literature. The maintenance lysine requirements of Nile tilapia and rainbow trout were estimated to be 31.9 and 18.6 (mg/kg/MBW d), respectively. These results suggest that maintenance requirements of fish cannot be assumed equal for all species. Four non-linear functions were proposed to quantify Fatemeh Nemati Shizari: University of Guelph, 2020 Advisor: Professor D.P. Bureau LysRE based on body weight and dietary lipid. Results demonstrated that LysRE decreases as the fish grows, and the lysine sparing effect of dietary lipid in both species was observed. In Study 2, the non-fecal phosphorus excretion was estimated through a mass-balance approach from data collected from dose-response studies on phosphorus retention. Three nonlinear models were tested to estimate non-fecal phosphorus excretion in relation with digestible phosphorus intake through a mixed-model approach. The endogenous urinary phosphorus loss in fed fish for Nile tilapia was 2.0±0.2 and that of rainbow trout was 4.0±0.4 (mg/kg/MBW d). The non-fecal phosphorus excretion at the maximum phosphorus retention was 31±37 for Nile tilapia and 39±15 (mg/kg/MBW d) for rainbow trout. In Study 3, a hybrid bioenergetic-based factorial model was developed to quantify the effect of body weight, dietary digestible energy and lipid content on lysine and phosphorus requirements. Overall, this study provides a valuable tool for formulating nutritionally balanced feed and developing farm management strategies.