Miracle-dz/UniFAR-FTUs huggingface dataset:
Unreliability of Clinical Prediction Rules to Exclude without Echocardiography Infective Endocarditis in Staphylococcus aureus Bacteremia

Background: It is unclear whether the use of clinical prediction rules is sufficient to rule out infective endocarditis (IE) in patients with Staphylococcus aureus bacteremia (SAB) without an echocardiogram evaluation, either transthoracic (TTE) and/or transesophageal (TEE). Our primary purpose was to test the usefulness of PREDICT, POSITIVE, and VIRSTA scores to rule out IE without echocardiography. Our secondary purpose was to evaluate whether not performing an echocardiogram evaluation is associated with higher mortality. Methods: We conducted a unicentric retrospective cohort including all patients with a first SAB episode from January 2015 to December 2020. IE was defined according to modified Duke criteria. We predefined threshold cutoff points to consider that IE was ruled out by means of the mentioned scores. To assess 30-day mortality, we used a multivariable regression model considering performing an echocardiogram as covariate. Results: Out of 404 patients, IE was diagnosed in 50 (12.4%). Prevalence of IE within patients with negative PREDICT, POSITIVE, and VIRSTA scores was: 3.6% (95% CI 0.1–6.9%), 4.9% (95% CI 2.2–7.7%), and 2.2% (95% CI 0.2–4.3%), respectively. Patients with negative VIRSTA and negative TTE had an IE prevalence of 0.9% (95% CI 0–2.8%). Performing an echocardiogram was independently associated with lower 30-day mortality (OR 0.24 95% CI 0.10–0.54, p = 0.001). Conclusion: PREDICT and POSITIVE scores were not sufficient to rule out IE without TEE. In patients with negative VIRSTA score, it was doubtful if IE could be discarded with a negative TTE. Not performing an echocardiogram was associated with worse outcomes, which might be related to presence of occult IE. Further studies are needed to assess the usefulness of clinical prediction rules in avoiding echocardiographic evaluation in SAB patients.
Possibly the oldest fish-made resting traces

Abstract The Silurian Sharawra Member (middle to late Llandoverian) in Saudi Arabia exhibits unique surface traces with exceptional preservation: Seven small, wing-shaped traces occur on a sandstone slab showing well-defined hummocky cross-stratification having a few decimeters wavelength being covered by a thin mud layer. These traces are preserved as concave epirelief along with elongated internal striae and surrounded by slightly elevated levees. Preservation of these delicate, 10–20 mm long and ∼10 mm wide traces suggests that they were formed after a storm event when mud had already settled to the sediment surface. The lack of wave-generated sedimentary structures implies deposition between fair-weather and storm-wave base probably preventing further rapid reworking by waves. Based on their geometry, internal pattern, and spatial distribution, these wing-shaped traces are interpreted to have been produced by relatively stationary bottom-feeding fish, morphologically similar to ancestors of Gobiidae, probably in the Actinopterygii class. The majority of fish-made trace fossils record feeding and locomotion behaviour, whereas the wing-shaped traces are interpreted to represent resting structures made by fish that pressed their fins downward on the muddy sediment surface and hence, represent undertracks. These traces are possibly the oldest fish-made structure documented thus far. These wing-shaped traces are described as Pisquiesichnus dashtgardi igen. et isp. nov. in this study.
Implementation of a data control framework to ensure confidentiality, integrity, and availability of high-quality real-world data (RWD) in the NeuroTransData (NTD) registry

Abstract Objective To implement a dynamic data management and control framework that meets the multiple demands of high data quality, rigorous information technology security, and flexibility to continuously incorporate new methodology for a large disease registry. Materials and Methods Guided by relevant sections of the COBIT framework and ISO 27001 standard, we created a data control framework supporting high-quality real-world data (RWD) studies in multiple disease areas. We first mapped and described the entire data journey and identified potential risks for data loss or inconsistencies. Based on this map, we implemented a control framework adhering to best practices and tested its effectiveness through an analysis of random data samples. An internal strategy board was set up to regularly identify and implement potential improvements. Results We herein describe the implementation of a data management and control framework for multiple sclerosis, one disease area in the NeuroTransData (NTD) registry that exemplifies the dynamic needs for high-quality RWD analysis. Regular manual and automated analysis of random data samples at multiple checkpoints guided the development and implementation of the framework and continue to ensure timely identification of potential threats to data accuracy. Discussion and conclusions High-quality RWD, especially those derived from long-term disease registries, are of increasing importance from regulatory and reimbursement perspectives, requiring owners to provide data of comparable quality to clinical trials. The framework presented herein responds to the call for transparency in real-world analyses and allows doctors and patients to experience an immediate benefit of the collected data for individualized optimal care.
Effect of SCUBA Diving on Ophthalmic Parameters

Background and Objective: Several cases of central serous chorioretinopathy (CSC) in divers have been reported in our medical retina center over the past few years. This study was designed to evaluate possible changes induced by SCUBA diving in ophthalmic parameters and especially subfoveal choroidal thickness (SFCT), since the choroid seems to play a crucial role in physiopathology of CSC. Materials and Methods: Intraocular pressure (IOP), SFCT, pachymetry, flow-mediated dilation (FMD), blood pressure, and heart rate were measured in 15 healthy volunteer divers before diving, 30 and 60 min after a standard deep dive of 25 m depth for 25 min in a dedicated diving pool (NEMO 33). Results: SFCT reduces significantly to 96.63 ± 13.89% of pre-dive values (p = 0.016) 30 min after diving. It recovers after 60 min reaching control values. IOP decreases to 88.05 ± 10.04% of pre-dive value at 30 min, then increases to 91.42 ± 10.35% of its pre-dive value (both p < 0.0001). Pachymetry shows a slight variation, but is significantly increased to 101.63 ± 1.01% (p = 0.0159) of the pre-dive value, and returns to control level after 60 min. FMD pre-dive was 107 ± 6.7% (p < 0.0001), but post-dive showed a diminished increase to 103 ± 6.5% (p = 0.0132). The pre-post difference was significant (p = 0.03). Conclusion: Endothelial dysfunction leading to arterial stiffness after diving may explain the reduced SFCT observed, but SCUBA diving seems to have miscellaneous consequences on eye parameters. Despite this clear influence on SFCT, no clear relationship between CSC and SCUBA diving can be drawn.
Pro-Inflammatory Cytokines Trigger the Overexpression of Tumour-Related Splice Variant RAC1B in Polarized Colorectal Cells

Simple Summary Tumours are now known to develop more quickly when the tumour cell mass is located in a tissue that shows signs of chronic inflammation. Under such conditions, inflammatory cells from the surrounding tumour microenvironment provide survival signals to which cancer cells respond. We have previously found that some colorectal tumours overexpress the protein RAC1B that sustains tumour cell survival. Here we used a colon mucosa-like in vitro cell model and found that the presence of cancer-associated fibroblasts and pro-inflammatory macrophages stimulated colorectal cells to increase their RAC1B levels. Under these conditions, the secreted survival signals were analysed, and interleukin-6 identified as the main trigger for the increase in RAC1B levels. The results contribute to understand the tumour-promoting effect of inflammation at the molecular level. Abstract An inflammatory microenvironment is a tumour-promoting condition that provides survival signals to which cancer cells respond with gene expression changes. One example is the alternative splicing variant Rat Sarcoma Viral Oncogene Homolog (Ras)-Related C3 Botulinum Toxin Substrate 1 (RAC1)B, which we previously identified in a subset of V-Raf Murine Sarcoma Viral Oncogene Homolog B (BRAF)-mutated colorectal tumours. RAC1B was also increased in samples from inflammatory bowel disease patients or in an acute colitis mouse model. Here, we used an epithelial-like layer of polarized Caco-2 or T84 colorectal cancer (CRC) cells in co-culture with fibroblasts, monocytes or macrophages and analysed the effect on RAC1B expression in the CRC cells by RT-PCR, Western blot and confocal fluorescence microscopy. We found that the presence of cancer-associated fibroblasts and M1 macrophages induced the most significant increase in RAC1B levels in the polarized CRC cells, accompanied by a progressive loss of epithelial organization. Under these conditions, we identified interleukin (IL)-6 as the main trigger for the increase in RAC1B levels, associated with Signal Transducer and Activator of Transcription (STAT)3 activation. IL-6 neutralization by a specific antibody abrogated both RAC1B overexpression and STAT3 phosphorylation in polarized CRC cells. Our data identify that pro-inflammatory extracellular signals from stromal cells can trigger the overexpression of tumour-related RAC1B in polarized CRC cells. The results will help to understand the tumour-promoting effect of inflammation and identify novel therapeutic strategies.
Virtual Team Adaptation: Management Perspective on individual Differences (preprint)

In the contemporary business world, digital transformations have undergone vast and important developments over the last several decades, and they have aided in the development of the virtual team concept, in which geographically dispersed team members work to achieve a common goal. Virtual teams, according to the literature, suffer from process losses more frequently than their face-to-face counterparts. Although just a few studies have looked at the effects of individual differences in virtual teams, this study fills in the gaps by examining the impact of individual differences: Age Disparity (AD), Gender Disparity (GD), Language Competency (LC), and IT Competency (ITC) in management perspective on virtual team adaptation in the Sri Lankan private sector. A survey was used to collect data from a sample of 175 private sector companies in Sri Lanka during the COVID- 19 pandemic, and the data was analyzed using partial least squares path modeling (PLS) to test the study's hypotheses. The results indicated that the hypotheses were statistically significant only in the language competency and IT competency and their effects were in the expected direction. Future research could benefit from perceptions of employees in public sector organizations.
A Novel Pyroptosis-Related Prognostic Signature for Risk Stratification and Clinical Prognosis in Clear Cell Renal Cell Carcinoma

Emerging research has substantiated that pyroptosis-related biomarkers were mightily related to the clinical outcome of patients with clear cell renal cell carcinoma (ccRCC). However, a single-gene biomarker's moderate predictive power is insufficient, and more accurate prognostic models are urgently needed. We conducted this investigation in order to develop a robust pyroptosis-related gene signature for use in risk stratification and survival prognosis in colorectal cancer. We downloaded transcriptomic data and survival information of ccRCC patients from TCGA. Bioinformatic methods were used to generate a pyroptosis-related gene signature based on data from TCGA training cohort. ROC curve, uni- and multivariate regression analyses were used for the prognostic assays. What is more, we explored the relationship between model-based risk score and the tumor microenvironment. Herein, 11 pyroptosis-related hub genes (CASP9, TUBB6, NFKB1, BNIP3, CAPN1, CD14, PRDM1, BST2, SDHB, TFAM, and GSDMB) were determined as risk signature for risk stratification and prognosis prediction for ccRCC. Kaplan-Meier curves, ROC curves, and risk plots were employed to analyze and verify its performance in all groups. Multivariate assays exhibited that risk score could be an independent prognostic factor for patients' OS. ESTIMATE algorithm showed a higher immune score in the group of high-risk. Overall, a novel pyroptosis-related gene signature generated can be employed for prognosis prediction of ccRCC patients. This may assist in individual treatment of clinical decision-making.
Ontario family justice in “lockdown”: Early pandemic cases and professional experience

Abstract The COVID‐19 pandemic has profoundly affected families and children involved in Ontario's family justice system as well as family justice professionals in the province. In a span of two years, Ontario's family justice system has been fundamentally transformed, from a paper‐based, in‐person system to a paperless system in which many services, including judicial proceedings, continue to be largely delivered remotely. We report on the findings of two studies on the impact of the COVID‐19 pandemic on Ontario family justice: (1) an analysis of early pandemic court decisions; and (2) a survey of family justice professionals about their experiences during the early pandemic. We describe how the pandemic has exacerbated access to justice issues for certain groups, including families experiencing high conflict, victims of intimate partner violence, families involved in child welfare proceedings, and self‐represented litigants, while improving access to justice for others by improving efficiency and reducing legal costs. As Ontario moves past the pandemic, the family justice system will need to ensure that technological advances improve access to justice for all court‐involved families.
Evaluation of Residential Areas with Different Spatial Patterns through Defensible Space Concept 

There are some differences in terms of spatial form in our cities that constantly change and grow with the developing technology. While some neighbourhoods develop with an organic and spontaneous urban texture, some neighbourhoods may have a grid or radial form. This study aims to examine the relationship between the crime rates and socio-spatial formation of the settlements. In this context, the adjacent Akşemsettin and Hırka-i Şerif Neighbourhoods, which are located in the Fatih District of Istanbul, Turkey and differ in spatial textures, have been selected as the study area. The former one has a grid form that was planned after a big fire that destroyed the traditional organic urban form. The latter one still exists with its traditional organic urban form with dead-end streets. The study area is examined through Oscar Newman's concept of "Defensible Space" and "Space Syntax method" developed by Bill Hillier & Julienne Hanson. The street networks of the grid and organic forms are analysed by the Space Syntax method in terms of axiality, intelligibility, connectivity and integration. Increasing crime rates and safety concerns as a result of rapid crowding of cities affect local and central governments' policy, planning and design decisions. This research forms an important basis for these decisions to create safer spaces in our cities and ensure that all public places of the city, such as streets and parking areas, provide a safe environment to the users. At the end of the study, it is expected that important results will be determined on how urban texture affects crime rates and sense of safety and what kind of factors should be taken into consideration in line with the city planning criteria.
Identifying possible misspecification in South African soybean oil futures contracts

ABSTRACT With the inclusion of a locally traded soybean oil futures contract, that is dual-listed and cash-settled of the Chicago Board of Trade futures contract, the South African Futures Exchange (SAFEX) aimed to provide local soybean crushing plants, the opportunity for managing their exposure toward the variation in soybean oil prices using effective hedging strategies. Which is only viable assuming adequate liquidity, that is currently lacking in these futures contracts. The soybean oil contract used for hedging local price exposure should also reflect local import parity and/or be correlated to local price movements. Therefore, with most soybean oil usually being imported from Argentina, one would expect SAFEX soybean oil futures contracts to reflect the cost of imported soybean oil from Argentina. Hence, the research study used the Engle–Granger (1987) cointegration approach, alongside a range of diagnostic tests to determine whether SAFEX soybean oil futures contracts, that is dual-listed and cash-settled of CBOT settlement values is a misspecification and whether or not SAFEX soybean oil futures contracts should rather be based on the Argentina free-on-board soybean oil prices which is a much better representation of South Africa’s import parity and local industry prices.
Anti-Microbial Activity of Phytocannabinoids and Endocannabinoids in the Light of Their Physiological and Pathophysiological Roles

Antibiotic resistance has become an increasing challenge in the treatment of various infectious diseases, especially those associated with biofilm formation on biotic and abiotic materials. There is an urgent need for new treatment protocols that can also target biofilm-embedded bacteria. Many secondary metabolites of plants possess anti-bacterial activities, and especially the phytocannabinoids of the Cannabis sativa L. varieties have reached a renaissance and attracted much attention for their anti-microbial and anti-biofilm activities at concentrations below the cytotoxic threshold on normal mammalian cells. Accordingly, many synthetic cannabinoids have been designed with the intention to increase the specificity and selectivity of the compounds. The structurally unrelated endocannabinoids have also been found to have anti-microbial and anti-biofilm activities. Recent data suggest for a mutual communication between the endocannabinoid system and the gut microbiota. The present review focuses on the anti-microbial activities of phytocannabinoids and endocannabinoids integrated with some selected issues of their many physiological and pharmacological activities.
IMPROVEMENT OF FIRM PERFORMANCE AND INTELLECTUAL CAPITAL THROUGH INNOVATION AND COMPETITIVE ADVANTAGE

Business is undergoing a change called the new wave, which is a change in (traditional) production-based economies into a knowledge-based economy. This is because Intellectual Capital is considered as a source that has a competitive advantage for a company. Information technology (IT) also provides many benefits for companies that use it well. One of the competitive advantages turns out that Intellectual Capital by Small and Medium Enterprises (SMEs) in Indonesia has not been utilized as an asset that can improve company performance. The method used in this study is a quantitative method. The purpose of this study is to explain the influence of Intellectual Capital and IT Competence on Innovation in improving Competitive Advantage and explain the moderating relationship between IT Competence and Knowledge Base View on Firm Performance. Intellectual Capital and IT Competence have no effect on Innovation in improving Competitive Advantage. Innovation serves as a full mediation of intellectual capital with firm performance. Likewise, the competitive advantage functions as a full mediation towards IT Competence and firm performance.
Reabilitação ambulatorial da COVID longa: uma chamada à ação

A COVID-19 tem consequências sensório motoras, cognitivas, psíquicas e nutricionais que necessitam de reabilitação. Objetivo: Descrever o programa de reabilitação ambulatorial desenvolvido no Instituto de Medicina Física e Reabilitação do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, otimizado, intensivo e de curta duração. Método: Obtivemos informações sociodemográficas e clínicas de 12 adultos com diagnóstico laboratorial de COVID-19, grave e crítica, que necessitaram de hospitalização na fase aguda. Avaliações funcionais: Escala de Medida de Independência Funcional (MIF), EQ-5D-5L, World Health Organization Disability Assessment Schedule (WHODAS 2.0), Post-COVID-19 Functional Status scale, Medical Research Council (MRC) dyspnea scale, escala visual analógica (EVA) para dor, DN-4 (Douleur Neuropathique 4), escala de sonolência de Epworth, Índice de Gravidade da Insônia, Montreal Ontario Cognitive Assessment (MoCA), escala de Depressão, ansiedade e estresse (DASS-21), avaliação nutricional, Timed Up and Go, teste de caminhada de 10 metros, teste de preensão palmar, MRC sum score, ultrassonografia musculoesquelética da coxa antes, durante e após programa de reabilitação ambulatorial. Este incluiu estimulação magnética indutiva e elétrica musculoesquelética, tratamento por ondas de choque extracorpóreas, exercícios isocinéticos, abordagem emocional, estimulação cognitiva, estimulação do desempenho ocupacional, orientação nutricional e programa educacional por aplicativo COMVC. O tratamento foi realizado duas vezes por semana até atingir os critérios de alta pré-estabelecidos. Resultados: VAS e TUG proporcionaram melhora estatisticamente significante (p <0,001). PCFS, MIF, Handgrip, 10 MWT e DASS-21 domínio ansiedade apresentam tendências de melhora. Conclusão: O programa melhora a dor, mobilidade e ansiedade em pacientes com COVID longa.
From social capital to social cohesion: Syrian refugees in Turkey and the role of NGOs as intermediaries

ABSTRACT Since the first Syrian refugees arrived in Turkey with the outbreak of the Syrian Civil War in 2011, NGOs have been a crucial actor in first distributing humanitarian aid and later facilitating refugees’ access to education, employment, and healthcare services. More recently, as intercommunal tension between Syrian refugees and the Turkish community has been increasing, many NGOs shifted their focus in building refugees’ social cohesion in Turkey. This study examines these efforts from a social capital perspective. We interviewed a total of twelve local/national, international and Syrian community-led NGOs working with refugees in İstanbul. We found that the intercommunal activities promoted by NGOs provide a space for both the Turkish and Syrian communities to meet, whose pathways would likely not cross otherwise. However, our study showed serious limitations in building bridging social capital as these activities attract participants already open to intercommunal dialogue and the language barrier hinders the sustainability of the relations. At the same time, however, we found that projects connecting refugees with people or institutions of authority have the potential to enhance social cohesion. These activities can facilitate refugees’ adaptation to the national system, which in turn entails more stable and sustainable relationship with Turkish people.
An Empirical Analysis of Export Competitiveness and Comparative Advantage of Pakistan’s Fruit Products

This study evaluates the global competitiveness of Pakistan's fruit exports for the period 2003-2019. The comparative advantage and competitiveness of fruit exports of Pakistan are examined by employing revealed comparative advantage (RCA), revealed symmetric comparative advantage' (RSCA), relative import advantage (RMA), relative trade advantage (RTA), Trade Balance Index (TBI) and Revealed Competitiveness Index (RC). The empirical findings illustrate that Pakistan had a comparative and competitive advantage in fruit exports during the period under consideration. The global competitiveness of Pakistan in the fruit exports indicates that there exists much potential for the growth of the horticultural sector. With government patronage and proper facilities, the fruit products can be a source of valuable foreign exchange earnings for the Pakistan economy.