Miracle-dz/UniFAR-FTUs huggingface dataset:
Minicapsules encapsulating nanoparticles for targeting, apoptosis induction and treatment of colon cancer

Abstract Cancer therapies are aimed at eliminating the rapidly growing tumor cells by surgery and radiotherapy. The present therapies are only fruitful in early identified cases. The present study involves the preparation and characterization of eudragit S100-coated mini-capsules filled with chitosan nanoparticles-unconjugated and folic acid (FA)-conjugated encapsulating caspase 3 activator (7-hydroxystaurosporine). The formulated nanoparticles were compared for the cancer targeting and curing ability of the same by pre-investigation through drug release in organ-imitated fluids and ex vivo studies (cell viability, DNA fragmentation, caspase 3 activity), and then its confirmation through in vivo studies (tumor regression and distribution). The prepared nanoparticles were nearly spherical in shape, having positive zeta potential. From the cell line studies, it can be concluded that both the conjugated formulations showed better uptake, apoptosis, caspase 3 activation and DNA fragmentation. Stability study was performed according to ICH guidelines and formulation stored at 5° ± 3 °C was found to be most stable. The in vivo studies also supported the findings and showed better comprehensive residence time (23.61 ± 1.75 h), tumor distribution profile than UCN 01 alone. The results of in vitro, ex vivo and in vivo studies lead to the conclusion that the coated minicapsules specifically deliver the drug in the colon showing high therapeutic value and low side effects.
The attractiveness of university and corporate anchor tenants in the conception of a new cluster

ABSTRACT Using an ex-ante, policymaker perspective, this study focuses upon a proposal for a new university (automotive) research institute (URI) – the University of Bath’s Institute for Advanced Automotive Propulsion Systems (IAAPS) – and its role in the conception of a new industrial cluster. Analysing unique survey data, we identify the key characteristics of the firms most likely to observe future potential benefits from the presence of this proposed public anchor (1) in isolation and (2) when the proposed public anchor is established with a research-based relationship with a co-located private anchor. We find the presence of a private anchor amplifies the attractiveness of the public anchor, heightening the likelihood of a cluster emerging. We discuss implications for policy.
Assessment of genetic diversity and DNA fingerprinting of aromatic rice varieties released by National Rice Research Institute ( NRRI )

Eastern India is one of the major producers and consumers of aromatic rice. Despite low yields, these aromatic rices are highly preferred by farmers and consumers due to their pleasant aroma and excellent cooking and eating quality. Over years, several new aromatic varieties have been released by different research organizations and private sector. The National Rice Research Institute, Cuttack has also been working on aromatic rice improvement and developed several breeding lines using different breeding approaches and released seven elite aromatic rice varieties. Understanding the variability and interrelationships among the released varieties will be of great help to us in planning the future aromatic rice improvement programs. The present study is an assessment of the diversity present in these aromatic rice varieties using microsatellite markers. The markers recorded high level of polymorphism with an average genetic diversity value (He) of 0.564. Also, these markers showed high discriminating power with an average polymorphism information content (PIC) of 0.734. Further, Ketekijoha and CR SugandhDhan 907 had lowest pair-wise genetic distance (0.425), whereas, Geetanjali and Nua Kalajeera were having highest genetic distance of 1.600. The Unweighted Pair Group Method with Arithmetic Mean (UPGMA) dendrogram could group the purelines, mutants and varieties into separate groups. Besides, DNA fingerprints of these seven varieties were generated will be of great help in protecting the IPR of the varieties.
Modelling of landslide propagation using two phases SPH depth integrated models

Modeling of fast landslide propagation is an important part of the process of landslide risk analysis. Once unstable masses have been identified at regional level, more accurate simulations can be done. Two important problems are (i) the uncertainties associated to the values of soil parameters (strength, soil cover, suction, etc) and actions triggering the landslide (rain, earthquakes) and (ii) the type of analysis describing the interaction between phases in the avalanching mass. In the case pore water pressures have developed, basal friction will change, influencing run out, velocity and heights of soil. Indeed, in order to design protecting structures such as racks, making basal pore pressures to decrease, coupled models with a description of pore pressures along depth have to be used. Interaction between soil particles and pore fluids depend on porosity, particle granulometry, fluid viscosity and relative velocities between phases. We will present here -following the work of Zienkiewicz and Shiomi (1984) a hierarchically structured set of mathematical models describing solid grains pore fluid interactions, from which depth integrated models can be developed. Constitutive and rheological models are fundamental ingredients of the general model. We will present here three categories of basal friction laws (i) ad hoc relations obtained from observations (ii) laws derived consistently from 3D rheological models, and (iii) viscoplastic laws of Perzyna type which can describe both triggering and propagation of the fluidized mixtures. Regarding discretization, we will present a two phases SPH model including nodes for soil and pore fluid particles, and incorporating, when required, sets of finite difference meshes associated to each solid SPH node to cope with pore pressures evolution. Some interesting aspects such as inflow, absorbent and zero normal velocity boundary conditions will be described. Finally, we will present some cases illustrating the modelling approaches proposed in the paper. ABSTRACT
Respiratory exposure with acrylonitrile butadiene styrene particle in appliance company workers

 Abstract Background: Acrylonitrile butadiene styrene granules heat up from169 to 32 0 C in the production of household appliance, which results in the decomposition of white smoke in the work place. Objective: Staff respiratory exposure with ABS granules vapors and dust examined. Methods: This analytical case-control study was performed on 78 persons of appliance manufacturing company in Qazvin, in 2016. Particles measurement 0.3 and 2.5 microns by Micro Dust Pro devices and Dust Counter and spirometry test were performed by Minispir. FEV1, FVC, FEV1/FVC parameters before and after invention platform on 8 meters height and respiratory signs staff complaints were considered by COPD assessment test. Findings: Forty-eight persons that exposed with vapor and dust ABS plastic material mostly had a lot of complaints to the frequent respiratory symptoms of cough and sputum occasionally. Spirometry indices coldwall staffs on the second floor including FEV1, FVC and the ratio FEV1/FVC were significantly decreased respectively (6.52%, 5.66%, 3.56 lit) during 2 years (P<0.05) and for coldwall staffs on the first floor, FEV1 and FVC significantly decreased respectively (9.26% and 5.6%) (P<0.05). But the ratio FEV1/FVC was not significant decreased. The three above mentioned indices for injection plastic staffs had significantly reduced (P<0.05), and increased for administrative staffs. Concentration of inhaled particles was 0.23±0.067 on the floor and particle at platform 0.62±0.24 mg/m 3 . Conclusion: It must be avoided to create a platform on the top of the hot source, such as plastic injection
Bimanual Skill Learning after Transcranial Direct Current Stimulation in Children with Unilateral Cerebral Palsy: A Brief Report

ABSTRACT Bimanual skills are important for goal-oriented activities. Children with unilateral cerebral palsy (UCP) have deficits in unimanual and bimanual motor control and learning. The application of non-invasive brain stimulation with existing motor training may further promote motor learning; however, the effects of stimulation on bimanual learning have not been examined. Here, we assessed the performance of a novel bimanual skill (modified Speed Stacks task) in eight children with UCP before, during, and after a combined motor training and brain stimulation intervention. Participants received 10 days (120 min/day) of goal-oriented bimanual therapy combined initially with transcranial direct current stimulation (tDCS, 20 min/day). Results showed task improvement tapered (p < 0.001) during and after the intervention and task variability decreased in 6/8 participants, indicating the potential impact of novel rehabilitation to improve skill learning in children with UCP. Future work is required to understand how both tDCS and bimanual training contribute to learning bimanual tasks.
ANALYSIS OF DATA HIDING ALGORITHMS FOR IMAGE SECURITY

The main goal of reversible data hiding algorithms is to embed the secret information in cover image and recover it back successfully. So we have implemented two methods. In first method, cover image is encrypted using stream cipher and pseudo randomly generated key and compressed using haar wavelet compression. The encrypted compressed image acts as a media for hiding secret image. And in second method, secret image is encrypted using randomly generated key and it is hidden in cover image. In both the method data hiding is done using LSB based image steganography. At the receiver, reverse process is done to extract secret image and recover cover image. At the end, we conclude that second method gives better security of image compared to method one.
MOLECULAR BREEDING AND PHYSIOLOGICAL MECHANISM OF DEVELOPING SALT-TOLERANCE IN RICE PLANT (Oryza Sativa L)

Rice (Oryza Sativa L.) is an important staple crop that feeds more than one half of the world’s population and is the model crop. Susceptibility or tolerance of rice plants to high salinity is a coordinated action of multiple stress-responsive genes, which also interacts with other components of stress signal transduction pathways. The salinity threshold for rice plants is 3 dS∙m−1 EC (electrical conductivity). Above this threshold, a 12% reduction in rice yield occurs if there is a 1 dS∙m−1EC increase in salinity. Rice seedlings die at a salt level corresponding to 10 dS∙m−1, and yield loss can be as high as 90% if the level reaches 3.5 dS∙m−1 during the reproductive stage. One way to address the salinity issue is to develop tolerant rice varieties using conventional, modern breeding techniques, and through genetic engineering by introducing salt-tolerance genes. Despite many attempts using different strategies to improve salinity tolerance in rice, the achievements so far are quite modest. This review aims to discuss challenges that hinder the improvement of salinity stress tolerance in rice as well as potential opportunities for enhancing salinity stress tolerance in rice.
University of Dundee Evaluating the effectiveness and reliability of the Vibrant Soundbridge and Bonebridge auditory implants in clinical practice

Background: The Vibrant Soundbridge middle ear implant and the Bonebridge bone conducting hearing device are hearing implants that use radio frequency transmission to send information from the sound processor to the internal transducer. This reduces the risk of skin problems and infection but requires a more involved surgical procedure than competitor skin penetrating devices. It is not known whether more complex surgery will lead to additional complications. There is little information available on the reliability of these systems and adverse medical or surgical events. The primary research question is to determine the reliability and complication rate for the Vibrant Soundbridge and Bonebridge. The secondary research question explores changes in quality of life following implantation of the devices. The tertiary research question looks at effectiveness via changes in au-
TOGA-COARE SOUNDING HUMIDITY DATA : IMPACT ON CLIMATE AND CONVECTION OVER THE WARM POOL

Shortly after the field phase of the 199293 Tropical Ocean Global Atmosphere (TOGA) Coupled Ocean-Atmosphere Response Experiment (COARE) it became apparent that the sounding systems used in the COARE Large Scale Array (LSA), a combination of Vaisalaand VIZmanufactured systems, exhibited a variety of humidity errors. Lucas and Zipser (2000) noted unrealistically small values of Convective Available Potential Energy (CAPE) at many of the Integrated Sounding System (ISS) sites, where Vaisala-H humidity sensors were used, and concluded that these sensors displayed a dry bias (∼5% in relative humidity) in the lower troposphere. They developed a correction algorithm for the Vaisala humidity data based on independent observations of surface humidity and their differences from sounding-determined mixedlayer mean values. Without the corrections, large horizontal gradients of low-level moisture over regions of nearly uniform sea surface temperature were observed, with CAPE varying by a factor of 2.5 over the COARE Intensive Flux Array (IFA) (Zipser and Johnson 1998). After corrections, a more homogeneous horizontal distribution of humidity over the IFA was achieved. Recently, Wang et al. (2002) investigated the humidity errors in the Vaisala systems used in COARE and developed a procedure for correcting them. Guichard et al. (2000) studied the impact of the errors for one site (R/V Moana Wave) and found that after application of the humidity corrections, the atmosphere exhibited more realistic values of CAPE and convective inhibition (CIN), comparable to those determined from aircraft observations. They also found an important effect of the corrected moisture fields on the surface radiative budget. It is worth emphasizing that these humidity corrections for the Vaisala systems are not unique to the COARE region, but are apply to operational systems used throughout the world.
United States Patent ( 19 ) Sebastian et al . 54 METHOD TO IDENTIFY GENETIC MARKERS THAT ARE LINKED TO AGRONOMICALLY IMPORTANT GENES

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Impact Factor : 2 . 098

Electrokinetic peristaltic multi-layered transport is considered in a micro-channel under the action of an axial electrical field. Three different layers i.e. the core layer, intermediate layer and peripheral layer are simulated with three different viscosities for each fluid layer. The unsteady two-dimensional conservation equations for mass and momentum with electrokinetic body forces, are transformed from the wave frame to the laboratory frame and the electrical field terms are rendered into electrical potential terms via the Poisson-Boltzmann equation, Debye length approximation and ionic Nernst Planck equation. The dimensionless emerging linearized electrokinetic boundary value problem is solved using integral methods. Closed-form expressions are derived for stream functions in the core, intermediate and peripheral layers. Expressions are also derived for the core-intermediate interface shape and the intermediate-peripheral interface shape. Maximum pressures are also computed. To study bolus migration, the range of the trapping limit is also determined in the peripheral layer. It is found that in the core layer larger boluses are computed in the case of lower intermediate layer viscosity relative to peripheral layer viscosity although the number of boluses is greater when the intermediate layer viscosity exceeds the peripheral layer viscosity. Furthermore, in the intermediate layer, stronger concentration of streamlines is computed in the lower half space with positive Helmholtz-Smoluchowski velocity. Also, negative Helmholtz-Smoluchowski velocity reduces the core layer (H1) interface shape whereas it enhances the peripheral layer (H) and intermediate layer (H2) shapes. At lower values of volume flow rate ratio, hydromechanical efficiency is maximum for positive Helmholtz-Smoluchowski velocity whether intermediate layer viscosity is less or greater than peripheral layer viscosity. Finally, greater with greater peristaltic wave amplitude and also for positive Helmholtz-Smoluchowski velocity there is an increase in time-averaged flow rate, whether intermediate layer viscosity is less or greater than peripheral layer viscosity. The analysis is relevant to electro-kinetic hemodynamics and bio-micro-fluidics.
Universiteit Leiden ICT in Business and the Private Sector Data mining in business A case study at Squeezely

In this thesis, we discuss how to build a recommender system for an online marketing company: Squeezely. We start by comparing different filtering approaches and ways of recommending. Then we continue to loss and training functions. We combine these factors into recommendation algorithm and run multiple of them so we can combine them through blending. Afterwards, we talk about some common problems that should be taken into account when building a recommender system. Then we continue to test some different setups to see if using more recommendation algorithms for blending improves our system. We finalize the thesis by implementing the theoretical outcome in real life recommender system at Squeezely.
Electrospun nanofibrous materialsfor wound healing applications

Developments in regenerative medicine and tissue engineering over the decades advanced wound healing methods for enhancing healing process and also overcome existing complications. Archetypically, wound is defined as a disruption of cellular community that consequences in separation of normally connected tissues or a type of injury resulted from the skin that is torn, cut, or punctured [1]. The breach occurred by skin damage leads to bacterial infection that causes inflammation and infection locally or systemically. The wound healing is not a simple linear process, which is one of the most complex and dynamic processes that involved with multiple biological pathways, blood elements, cells, growth factors, and extracellular matrix (ECM) [2–4]. Eventually, wound healing occurs through three stages, namely, (a) inflammation, (b) new tissue formation, and (c) remodeling. The inflammation stage of wound healing process happens immediately following the tissue damage and lasts about 48 h. During this stage, multiple biological pathways are initiated to prevent blood and fluid losses and infection and remove dead and devitalized (dying) tissues. The second stage of the wound healing process occurs between 2 and 10 days after injury and which is characterized by cellular proliferation and migration of different cell types. The third stage of the wound healing is remodeling, and it begins after 2–3 years following the injury and lasts for a year or more in which all the process activated after injury wind down and cease. The detailed information on different stages of the wound repair process is depicted in Fig. 8.1 [4]. Based on the wound repair process, wounds are classified into acute and chronic wounds. Acute wounds are generally healing completely within 8–12 weeks time frame, whereas the chronic wounds take more than 12 weeks for healing process [5,6]. Wound management complications are always having significant impacts in clinical burden; thus, the wound dressing market has great economic potential worldwide [7]. Therefore, recent decades witnessed that a variety of wound dressing materials resulted from numerous approaches have been introduced at different aspects of wound healing process [8]. Development of wound dressing can be tracked back since ancient era from application of medicinal plant, animal fat, and honey to tissue engineering scaffolds. An
Comparison of the Entheseal Changes of the os coxae of PortugueseMales ( 19 th – 20 th centuries ) with Known Occupation

The possible association between entheseal changes and activity has been widely studied. However, many questions remain. This study aims to assess if occupation and physical activity influence the age at which entheseal changes appear in the iliac crest, retroauricular area, iliac tuberosity, ischial tuberosity and obturator foramen. Absence or presence of ossification exostosis and stress lesions was recorded in os coxae from 130 males (19 to 88 years old) from Lisbon and Coimbra identified skeletal collections. The individuals were divided into two groups, based upon to the recorded occupations: manual (n=69) and non-manual (n=61). The sample was also divided according to an osteological indicator of physical activity: the femur robusticity index (55 are robust and 54 are gracile femora). The individuals from manual and robust groups were considered to have had physically demanding occupations, while the non-manual and gracile groups represent individuals with less demanding activities. The asymmetry of entheseal changes between left and right sides of the same individuals was tested with a Chi-square test. And the influence of occupation and physical activities on the age of appearance of entheseal changes was tested using logistic regression. Statistically significant asymmetry was not found between left and right bones (p <0.05). However, for the logistic regression calculations, the only valid result was obtained for the ossification exostosis on the iliac crest for the measure of femoral robusticity. For the iliac crest, physical activity did not influence the appearance of ossification exostosis. It was not possible to obtain valid logistic regression models, probably due to the distribution of individuals in each occupational and robusticity category. Therefore, it was not possible to assess the influence of occupation and physical activity on the age at which entheseal changes appeared for retroauricular area, iliac tuberosity, ischial tuberosity and obturator foramen. Copyright © 2012 John Wiley & Sons, Ltd.
Market Efficiency and Insider trading : Evidence from the Egyptian Stock Exchange

Insider trading in securities occurs when a person in possession of nonpublic information about a company trades in the company’s securities. Insider traders enjoy a much favorable position than other non-insider traders because of their possession of such nonpublic information, and as a result insider trading has been a major issue for stock markets, regulators and of course researchers. In order to avoid problems of information asymmetry all countries have implemented regulations, forcing insiders to provide information concerning selling or buying shares of their firms. Preventing insider trading from taking advantage over other investors is necessary to comply with securities laws. This paper reviews the existing studies on insider trading, market efficiency, regulation and laws of insider trading, and then it examines the trading activities of insiders in the Egyptian stock exchange. The statistical difference between insider trading and average market returns is then tested. Market Efficiency and Insider trading Dr . HatemAlBanna– Dr.FadyTawako 24/12/2017 Scientific Journal for Economic& Commerce 640 Results show that differences between insider trading and average market is not significantly different than zero, which encouragingly supports possibility of achieving the strong-form efficiency hypothesis in the Egyptian stock market.