Miracle-dz/UniFAR-FTUs huggingface dataset:
High-Resolution Mass Spectrometry Identification of Secondary Metabolites in Four Red Grape Varieties Potentially Useful as Traceability Markers of Wines

Liquid chromatography coupled to high-resolution mass spectrometry (LC-Q/TOF) is a powerful tool to perform chemotaxonomic studies through identification of grape secondary metabolites. In the present work, the metabolomes of four autochthonous Italian red grape varieties including the chemical classes of anthocyanins, flavonols/flavanols/flavanones, and terpenol glycosides, were studied. By using this information, the metabolites that can potentially be used as chemical markers for the traceability of the corresponding wines were proposed. In Raboso wines, relatively high abundance of both anthocyanic and non-anthocyanic acyl derivatives, is expected. Potentially, Primitivo wines are characterized by high tri-substituted flavonoids, while Corvina wines are characterized by higher di-substituted compounds and lower acyl derivatives. Negro Amaro wine’s volatile fraction is characterized by free monoterpenes, such as α-terpineol, linalool, geraniol, and Ho-diendiol I. A similar approach can be applied for the traceability of other high-quality wines.
Long Term Survival Probabilities and Kaplan-Meier Estimator Ion Grama

The Kaplan-Meier nonparametric estimator has become a standard tool for estimating a survival time distribution in a right censoring schema. However, if the censoring rate is high, this estimator do not provide a reliable estimation of the extreme survival probabilities. In this paper we propose to combine the nonparametric Kaplan-Meier estimator and a parametric-based model into one construction. The idea is to fit the tail of the survival function with a parametric model while for the remaining to use the Kaplan-Meier estimator. A procedure for the automatic choice of the location of the tail based on a goodness-of-fit test is proposed. This technique allows us to improve the estimation of the survival probabilities in the mid and long term. We perform numerical simulations which confirm the advantage of the proposed method.
Frobenius Series Solutions of the Schrodinger Equation with Various Types of Symmetric Hyperbolic Potentials in One Dimension

The Schrodinger equation (SE) for a certain class of symmetric hyperbolic potentials is solved with the aid of the Frobenius method (FM). The bound state energies are given as zeros of a calculable function. The calculated bound state energies are successively substituted into the recurrence relations for the expanding coefficients of the Frobenius series representing even and odd solutions in order to obtain wave functions associated with even and odd bound states. As illustrative examples, we consider the hyperbolic Poschl-Teller potential (HPTP) which is an exactly solvable potential, the Manning potential (MP) and a model of the Gaussian potential well (GPW). In each example, the bound state energies obtained by means of the FM are presented and compared with the exact results or the literature ones. In the case of the HPTP, we also make a comparison between exact bound state wave functions and the eigenfunctions obtained by means of the present approach. We find that our results are in good agreement with those given by other methods considered in this work, and that our class of potentials can be a perfect candidate to model the GPW.
Do House Prices Influence the Effect of Monetary Policy Shocks on Private Consumption? -Evidence From Five EMU Member States

The aim of this thesis is to study the role of house prices in influencing the effect of monetary policy shocks on private consumption in five EMU member states during the period 1995Q1-2010Q4. The role of house prices may be increasingly important in effecting private consumption possibilities due to the deregulations of mortgage markets in many countries in recent years and the increasing availability of mortgage equity products. Moreover, this study investigates whether or not changing credit market conditions during a recession may have any influence on the role of house prices. Using structural VAR models to be able to identify the interest rate shocks, the response of consumption in the absence and presence of house prices is studied through impulse response analysis. The results show that house price sensitivity to monetary policy shocks is more pronounced in countries with more developed mortgage markets. While there was a visible and non-temporary divergence between the impulse responses of consumption in the two versions of the model (including and excluding house prices, respectively), this could not be proven to be statistically significant. Three out of five countries display a larger house price effect when using data from the whole period as opposed to the house price effect observed when using only data from the pre-crisis period, 1995Q1-2007Q2. However, the results were not statistically significant.
ICP 27 protein of Marek ’ s disease virus interacts with SR proteins and inhibits the splicing of cellular telomerase chTERT and viral vIL 8 transcripts

All herpesviruses have a post-transcriptional regulatory protein that prevents precursor mRNA splicing and leads to the shutting off of host protein synthesis. The ICP27 protein of herpes simplex virus 1 (HSV-1) is the prototype of these proteins. Marek’s disease virus (MDV-1), an alphaherpesvirus that induces lymphoma in birds, also has an ICP27 protein that is produced in lytic MDV-1-infected cells. We characterized this protein. We demonstrated ICP27 production in latently infected MSB-1 cells, but only on MDV-1 reactivation. ICP27 was found predominantly in specific structures within the nucleus. The ICP27 of MDV-1 colocalized and interacted with SR proteins. We demonstrated inhibitory effects of MDV-1 ICP27 on the splicing of both the viral vIL8 and cellular chTERT (telomerase reverse transcriptase) genes. Thus, the ICP27 of MDV-1 plays a similar role to the ICP27 of HSV-1 and may be involved in MDV-1 replication and the development of Marek’s disease.
Fast Robust Correlation for High-Dimensional Data

Abstract The product moment covariance matrix is a cornerstone of multivariate data analysis, from which one can derive correlations, principal components, Mahalanobis distances and many other results. Unfortunately, the product moment covariance and the corresponding Pearson correlation are very susceptible to outliers (anomalies) in the data. Several robust estimators of covariance matrices have been developed, but few are suitable for the ultrahigh-dimensional data that are becoming more prevalent nowadays. For that one needs methods whose computation scales well with the dimension, are guaranteed to yield a positive semidefinite matrix, and are sufficiently robust to outliers as well as sufficiently accurate in the statistical sense of low variability. We construct such methods using data transformations. The resulting approach is simple, fast, and widely applicable. We study its robustness by deriving influence functions and breakdown values, and computing the mean squared error on contaminated data. Using these results we select a method that performs well overall. This also allows us to construct a faster version of the DetectDeviatingCells method (Rousseeuw and Van den Bossche 2018) to detect cellwise outliers, which can deal with much higher dimensions. The approach is illustrated on genomic data with 12,600 variables and color video data with 920,000 dimensions. Supplementary materials for this article are available online.
Characterization of InGaAs-based cameras for astronomical applications using a new VIS-NIR-SWIR detector test bench

A new test bench for detector and camera characterization in the visible and near-infrared spectral range between 350 -2500 nm has been setup at the Max Planck Institute for Solar System Research (MPS). The detector under study is illuminated by an integrating sphere that is fed by a Czerny-Turner monochromator with quasi-monochromatic light. A quartz tungsten halogen lamp is used as a light source for the monochromator. Si- and InGaAs-based photodiodes have been calibrated against secondary reference standards at PTB (Germany), NPL (UK) and NRC (Canada) for precise spectral flux measurements. The test bench allows measurements of fundamental detector properties such as linearity of response, conversion gain, full well capacity, quantum efficiency (QE), fixed pattern noise and pixel response non-uniformity. The article will focus on the commissioning of the test bench and subsequent performance evaluation and characterization of a commercial camera system with a 640 x 480 InGaAs-detector, sensitive between 900 to 1650 nm. The study aimed at the potential use of InGaAs cameras in ground-based and airborne astronomical observations or as target acquisition and tracking cameras in the NIR supporting infrared observations at longer wavelengths, e.g. on SOFIA. An intended future application of the test bench in combination with an appropriate test dewar is the characterization of focal plane assemblies for imaging spectrometers on spacecraft missions, such as the VIS-SWIR channel of MAJIS, the Moons and Jupiter Imaging Spectrometer aboard JUICE (Jupiter Icy Moons Explorer).
Aalborg Universitet A Lumped-Charge Approach Based Physical SPICE-Model for High Power Soft-Punch Through

This paper presents a new lumped-charge approach based physical model for high power soft-punch through (SPT) IGBT. IGBT physical models should consider the fabrication technologies used to optimize the device behaviour for specific applications. The proposed model focuses on the chip structure designed by ABB for high power IGBT and can apply to other IGBTs with homogeneous structures. Based on the SPT+ concept combined with an enhanced planar cell design for the optimization of lower power losses, different particular mathematical approaches are used to describe their functions in the proposed model. The temperature dependence of the model is also included because the chip temperature of IGBT in practical applications is higher than the room temperature and changed with service conditions. The physics-based IGBT model has been implemented in PSpice and validated with experiments, which considers both the block voltage non-punch through (NPT) condition and punch through (PT) condition during turn-off transient. The simulation results show a good agreement with the experiment results.
Optimized Compilation of Executable UML / SysML Diagrams for the Design of Data-Flow Applications

Future 5G radio access networks (RANs) are expected to provide higher (10x) data-rates and to support use cases such as the Internet of Things and cloud computing. To meet the computational requirements of these use cases, RAN servers will accelerate the execution of data-intensive computations (e.g., signal-processing applications) onto reconfigurable components (e.g., FPGAs). This change in the servers’ architecture raises the need for novel tools capable to rapidly automate the programming of these mixed hardware/software systems in a world that has been traditionally dominated by IT software. At DATE 2018 University Booth, we demonstrate our latest improvements in the compilation of system-level models for a 5G data-link layer receiver, as defined in release 15 by the 3GPP consortium [1], for the single antenna case, in the uplink (SC-FDMA), eNodeB side. In our design flow, Fig. 1, models that specify different views (functionality, architecture and communication protocols) are created in TTool/DIPLODOCUS [2], a UML/SysML framework for the rapid prototyping of data-flow systems.
The Eocene-Oligocene planktic foraminiferal transition: extinctions, impacts and hiatuses

Abstract Biostratigraphic study and re-examination of 22 late Eocene to early Oligocene sections provides data in support of three and possibly a fourth late Eocene impact events in the G. index Zone during a period of about 1 Ma of the middle Priabonian between 34.7 and 35.7 Ma. No major species extinctions or significant species abundance changes directly coincide with these impact events. Species extinctions are gradual and selective, affecting primarily cool-temperature-intolerant surface dwellers. These extinctions began with the onset of global cooling during the early middle Eocene and culminated near the Eocene/Oligocene boundary. The global cooling was associated with the isolation of Antarctica as Australia moved northward, the development of a circum-Antarctic circulation, growth of Antarctic ice sheet beginning by late middle Eocene time and a change from a thermospheric to thermohaline circulation. We find no evidence that the multiple late Eocene impact events directly contributed to the climatic deterioration already in progress.
Numerical solutions for micropolar transport phenomena over a nonlinear stretching sheet

We present a numerical study for the steady, coupled, hydrodynamic, heat and mass transfer of an incompressible micropolar fluid flowing over a nonlin ear stretching sheet. The governing differential equations are partially decoupled usin g a similarly transformation and then solved by two numerical techniques - the finite elem ent method and the finite difference method. The dimensionless translational velocity, microrotation (angular velocity), temperature and mass distribution function are computed for the different thermophysical parameters controlling the flow regime, viz the nonlinear (stretching) parameter, b, Grashof number, G and Schmidt number, Sc. All results are shown graphically. Additionally skin friction and Nusselt number, which provide an estimate of the surface shear stress and the rate of cooling of the surfac e, respectively, are also computed. Excellent agreement is obtained between both numerical methods. The dimensionless translational velocity (f ' ) for both micropolar and Newtonian fluids is shown to decrease with an increase in nonlinear parameter b. Dimensionless micro- rotation (angular velocity), g, generally increases with a rise in nonlinear parameter b (in particular in the vicinity of the wall) and decreases with a rise in convective pa rameter, G. The effects of other parameters on the flow variables are also discuss ed. The flow regime has significant applications in polymer processing technology and metallurgy.
Comparison of bioassessment methods of ecological condition using aquatic macroinvertebrate assemblages in Southwest Georgia headwater streams

Despite their importance, most biomonitoring programs ignore headwater streams, and focus their usually limited resources on larger streams. This study compared aquatic macroinvertebrate assemblages using Georgia Department of Natural Resources’ (DNR) Georgia Bioassessment Protocol (GBP) and Georgia Adopt-A-Stream’s (AAS) assessment protocol for four relatively undisturbed headwater streams. The rating of ecological condition/water quality of study streams by the GBP and AAS index differed slightly with a greater percentage of samples rated excellent or poor by the AAS index when compared to GBP results. The AAS index detected differences between sampling periods and streams that agreed with commonly used metrics such as Ephemeroptera, Plecoptera, and Trichoptera (EPT) taxa. Study results do not suggest that one assessment method is better at describing streams than the other, but they do suggest that the coarser taxonomic resolution employed by the AAS index is adequate to conduct assessments.
Hydrogen Balmer Line Broadening in Solar and Stellar Flares

The broadening of the hydrogen lines during flares is thought to result from increased charge (electron, proton) density in the flare chromosphere. However, disagreements between theory and modeling prescriptions have precluded an accurate diagnostic of the degree of ionization and compression resulting from flare heating in the chromosphere. To resolve this issue, we have incorporated the unified theory of electric pressure broadening of the hydrogen lines into the non-LTE radiative-transfer code RH. This broadening prescription produces a much more realistic spectrum of the quiescent, A0 star Vega compared to the analytic approximations used as a damping parameter in the Voigt profiles. We test recent radiative-hydrodynamic (RHD) simulations of the atmospheric response to high nonthermal electron beam fluxes with the new broadening prescription and find that the Balmer lines are overbroadened at the densest times in the simulations. Adding many simultaneously heated and cooling model loops as a “multithread” model improves the agreement with the observations. We revisit the three-component phenomenological flare model of the YZ CMi Megaflare using recent and new RHD models. The evolution of the broadening, line flux ratios, and continuum flux ratios are well-reproduced by a multithread model with high-flux nonthermal electron beam heating, an extended decay phase model, and a “hot spot” atmosphere heated by an ultrarelativistic electron beam with reasonable filling factors: ∼0.1%, 1%, and 0.1% of the visible stellar hemisphere, respectively. The new modeling motivates future work to understand the origin of the extended gradual phase emission.
Direct solution of compensated radial distribution networks with constant impedance/current loads

In this paper, a methodology to solve radial distribution networks, with constant current and/or impedance loads as well as shunt capacitor banks, is proposed. The techniques currently available to solve such systems are based either on iterative methods or on the bus impedance matrix. In both cases, the elaboration times are quite high since these are related, for iterative methods, to the overall number of iterations, and, for those methods based on the impedance matrix, to the inversion of the admittance matrix. The method developed here is the extension of a technique that is valid to solve networks made of impedances with one supply point. The methodology can also be applied in the solution, with the backward/forward methodology, of meshed systems having voltage-dependent loads and PV nodes. After having described the two cited networks' analysis methodologies, the new methodology is developed and its implementation is described. The comparison of the computational performances, in terms of CPU times, between the iterative method, the method using the bus impedance matrix and the one developed in this paper provide evidence regarding the efficiency of the latter in strongly reducing the calculation times.
Preservation of a rural and cultural landscape. Insights from the multinomial and error components logit model

The present paper uses the discrete choice experiments to elicit visitors�preferences for a hypothetical preservation program of the main attributes ofthe Alto Douro Wine Region, an evolving rural and cultural landscape, classifiedby UNESCO as world heritage site. The paper compares the performanceof the multinomial logit model, relying on the independence assumptionbetween the choices made by the same respondent, with the error componentslogit model that explicitly considers the panel data structure.There is evidence that the utility of participating in a preservation program ispositively determined by the income level and by the status of ADW� worldheritage list. Moreover, the utility is negatively influenced by household size andby the distance between the residence and the ADW.
The Political Biographies of Social Workers: A Qualitative Study of the Political Lives of Social Workers

This paper will explore the political biographies of social workers in a neoliberal era. The findings are based on a research project for a successfully completed professional doctorate in social work. The methodology deployed for the research is a combination of constructivist grounded theory and biographical inquiry. The paper will present findings from 14 biographical interviews and will focus on one case study of a participant whose life story is richly informed by political social work. The 14 participants reflect different genders, ethnic identities, cultural and linguistic identities, age and length of social work careers. The participants also reflect different forms of political engagement, such as, as political activists and members of political parties, including parliamentarians. The findings demonstrate how deeply ingrained the social work identity is amongst the participants and how their political identity has remained strongly social democratic in nature despite the many changes in the social work profession since the rise of neoliberalism as a thought collective and policy package. The individual case study will explore the early roots of political identity in the childhood and nurturing years and the interface with subsequent social work and political careers. It will also explore the evolution of the participant’s political identity in the social work career. The case study will also present findings on how the participant has contributed to the political field with policy involvement and initiatives. The presentation will conclude with a discussion on how this particular group of social workers can best contribute to the future direction of the social work profession. Keywords—Political social work, political biographies, neoliberal, grounded theory.
Cardiovascular tissue engineering and regeneration based on adipose tissue-derived stem / stromal cells

Stem cell therapy to treat cardiovascular disease is in need to improved tissue retention. As a first step, we developed delivery collagen based scaffolds i.e. microspheres (MS) to adhere stem cells. Recombinant collagen peptide-based (RCP-RGD and RCP-DGR) microspheres (MS) was used to generate two types of MS (average size 50μm) via chemical crosslinking hexamethylene diisocyanate (HMDIC) Human adipose tissue-derived stromal cells (ADSC) were seeded onto the MS and cultured overnight. Stem cell-loaded or bare MS were injected subcutaneously on the back of rats. The injected MS and surrounding tissue were dissected at day 1, 3, 14 and 28 to investigate biological response. Our results showed that HMDIC cross-linked RCP MS supported the adhesion of ADSC as assessed through SEM analyses. The tissue response comprised of influxes of inflammatory cells such as macrophages as well as vascularization. The loading of ADSC on RCP MS caused a reduced influx of macrophages at d14 and at d28 the deposition of collagen was lower in ADSC-loaded MS implants compared to controls. The loading of ADSC onto both types of MS did not affect the vascularization during the tissue response. The newly deposited extracellular matrix was produced mainly by fibroblasts, while myofibroblasts were not detectable in any explant. Degradation of the MS was observed at day 14 and 28. In conclusion, we showed that (ADSC) RCP MS are suitable for tissue repair with an appropriate tissue reaction after subcutaneous implantation.