Miracle-dz/UniFAR-FTUs huggingface dataset:
Improving Cross-Lingual Word Embeddings by Meeting in the Middle

Cross-lingual word embeddings are becoming increasingly important in multilingual NLP. Recently, it has been shown that these embeddings can be effectively learned by aligning two disjoint monolingual vector spaces through linear transformations, using no more than a small bilingual dictionary as supervision. In this work, we propose to apply an additional transformation after the initial alignment step, which moves cross-lingual synonyms towards a middle point between them. By applying this transformation our aim is to obtain a better cross-lingual integration of the vector spaces. In addition, and perhaps surprisingly, the monolingual spaces also improve by this transformation. This is in contrast to the original alignment, which is typically learned such that the structure of the monolingual spaces is preserved. Our experiments confirm that the resulting cross-lingual embeddings outperform state-of-the-art models in both monolingual and cross-lingual evaluation tasks.
Qip gene in Fusarium oxysporum is required for normal hyphae morphology and virulence

Ribonucleic acid (RNA)-silencing mechanisms exist in many eukaryotes to regulate a variety of biological processes. The known molecular components are related to Dicers, Argonautes and RNA-dependent RNA polymerases. Previous biochemical studies have also suggested that Qip, with an exonuclease domain, facilitates the conversion of duplex small interfering RNAs into single strands. In our study, the Qip gene in Fusarium oxysporum was disrupted using homologous recombination technology. The deletion of the Qip gene resulted in a decrease in colony growth rates but increased the number of branches. Additionally, the ΔQip mutant had a reduced pathogenicity in cabbage. Our results show Qip gene in F. oxysporum is required for normal hyphae morphology and virulence. The mutant will be useful for elucidating the relationship between the RNA-silencing mechanism and hyphal growth and development in F. oxysporum.
Prolonged middle ear development in Rhinella horribilis

Despite the benefit of the tympanic middle ear to airborne hearing sensitivity, anurans range in how soon they develop functional middle ears after transitioning to life on land. Previous evidence suggested that bufonids had particularly slow middle ear developmental rates, but precise timelines have not yet been published for this family. Here, we provide the first age‐verified middle ear development timeline for a true toad species (family Bufonidae). We find that although middle ear development begins during metamorphosis in Rhinella horribilis, the middle ear remains incomplete 15 weeks after the transition from aquatic tadpole to land‐dwelling toadlet. Using this new middle ear timeline, we discuss commonalities and differences in middle ear development among bufonids, as well as among Anura.
A Syntactically Constrained Bidirectional-Asynchronous Approach for Emotional Conversation Generation

Traditional neural language models tend to generate generic replies with poor logic and no emotion. In this paper, a syntactically constrained bidirectional-asynchronous approach for emotional conversation generation (E-SCBA) is proposed to address this issue. In our model, pre-generated emotion keywords and topic keywords are asynchronously introduced into the process of decoding. It is much different from most existing methods which generate replies from the first word to the last. Through experiments, the results indicate that our approach not only improves the diversity of replies, but gains a boost on both logic and emotion compared with baselines.
Oxidative damage and antioxidant defense are assay and tissue‐dependent both in captive and wild‐caught bank voles (Myodes glareolus) before and after reproduction

Abstract Reproduction is costly and life‐history theory predicts that current parental investment will result in lower survival or decreased future reproduction. The physiological mechanisms mediating the link between reproduction and survival are still under debate and elevated oxidative damage during reproduction has been proposed as a plausible candidate. Previous studies of oxidative stress during reproduction in animals under natural conditions have been restricted to analyses of blood. Herein, we measured the level of oxidative damage to lipids (tiobarbituric‐acid‐reactive substances) and proteins (carbonyls) in the liver, kidneys, heart and skeletal muscles in free‐living bank vole females from spring and autumn generations, before and after reproduction. Antioxidant defense in the liver and kidneys was also determined. We expected oxidative damage to tissues and hypothesized that the damage would be more uniform between tissues in wild animals compared to those breeding under laboratory conditions. Considering all combinations of markers/tissues/generations, oxidative damage in females did not differ before and after reproduction in 12 comparisons, was lower after reproduction in three comparisons, and was higher after breeding in one comparison. The total glutathione was significantly increased after reproduction only in the liver of the autumn generation and there was no change in catalase activity. Our results confirm—for the first time in the field—previous observations from laboratory studies that there is no simple link between oxidative stress and reproduction and that patterns depend on the tissue and marker being studied. Overall, however, our study does not support the hypothesis that the cost of reproduction in bank voles is mediated by oxidative stress in these tissues.
Muscle Synergies Obtained from Comprehensive Mapping of the Cortical Forelimb Representation Using Stimulus Triggered Averaging of EMG Activity

Neuromuscular control of voluntary movement may be simplified using muscle synergies similar to those found using non-negative matrix factorization. We recently identified synergies in electromyography (EMG) recordings associated with both voluntary movement and movement evoked by high-frequency long-duration intracortical microstimulation applied to the forelimb representation of the primary motor cortex (M1). The goal of this study was to use stimulus-triggered averaging (StTA) of EMG activity to investigate the synergy profiles and weighting coefficients associated with poststimulus facilitation, as synergies may be hard-wired into elemental cortical output modules and revealed by StTA. We applied StTA at low (LOW, ∼15 μA) and high intensities (HIGH, ∼110 μA) to 247 cortical locations of the M1 forelimb region in two male rhesus macaques while recording the EMG of 24 forelimb muscles. Our results show that 10–11 synergies accounted for 90% of the variation in poststimulus EMG facilitation peaks from the LOW-intensity StTA dataset while only 4–5 synergies were needed for the HIGH-intensity dataset. Synergies were similar across monkeys and current intensities. Most synergy profiles strongly activated only one or two muscles; all joints were represented and most, but not all, joint directions of motion were represented. Cortical maps of the synergy weighting coefficients suggest only a weak organization. StTA of M1 resulted in highly diverse muscle activations, suggestive of the limiting condition of requiring a synergy for each muscle to account for the patterns observed. SIGNIFICANCE STATEMENT Coordination of muscle activity and the neural origin of potential muscle synergies remains a fundamental question of neuroscience. We previously demonstrated that high-frequency long-duration intracortical microstimulation-evoked synergies were unrelated to voluntary movement synergies and were not clearly organized in the cortex. Here we present stimulus-triggered averaging facilitation-related muscle synergies, suggesting that when fundamental cortical output modules are activated, synergies approach the limit of single-muscle control. Thus, we conclude that if the CNS controls movement via linear synergies, those synergies are unlikely to be called from M1. This information is critical for understanding neural control of movement and the development of brain–machine interfaces.
Investigating the usability and user experiences of voice user interface: a case of Google home smart speaker

Recently, commercial Voice User Interfaces (VUIs) have been introduced to the market (e.g. Amazon Echo and Google Home). Although they have drawn much attention from users, little is known about their usability, user experiences, and usefulness. In this study, we conducted a web-based survey to investigate usability, user experiences, and usefulness of the Google Home smart speaker. A total of 114 users, who are active in a social-media based interest group, participated in the study. The findings show that the Google Home is usable and user-friendly for users, and shows the potential for international users. Based on the users' feedback, we identified the challenges encountered by the participants. The findings from this study can be insightful for researchers and developers to take into account for future research in VUI.
Appropriation of wearable augmented reality

Wearables, like augmented reality glasses, are more and more commercially available but uptake has been slow and concerns on social and ethical implications are raised. Current adoption theories can provide insights into the adoption or rejection process, but very few studies are conducted in this field to address the social and ethical implications of wearables. This paper provides results about the inclusion of different perspectives, namely diffusion and adoption theories, mutual shaping perspectives and philosophy of technology to study the social interactions and ethical implications of wearables as well. By following this path we would like to develop a model of appropriation in the future to get a better understanding of the acceptance and interactions of emerging technologies such as wearable augmented reality.
Geological classification and mapping of technogenic (artificial) ground: a comparative analysis

Artificial or technogenic grounds have been described in geological literature since the 19th century. However, their intense study, classification and systematic mapping have been carried out only since the 1980s, the principal contributions having originated in the former Soviet Union and Eastern Europe, the United Kingdom, the United States of America, Japan and Brazil, among others. Here we present a comparative analysis of some these main contributions, based upon their application to a hypothetical area, in order to verify their potential use and the adequacy of their methods. It is concluded that the combined use of characteristics of these approaches may be the most adequate depending on the purpose of the study and the scale adopted for mapping.
Clinical, electrophysiological, and cutaneous innervation changes in patients with bortezomib-induced peripheral neuropathy reveal insight into mechanisms of neuropathic pain

Bortezomib is a mainstay of therapy for multiple myeloma, frequently complicated by painful neuropathy. The objective of this study was to describe clinical, electrophysiological, and pathological changes of bortezomib-induced peripheral neuropathy (BiPN) in detail and to correlate pathological changes with pain descriptors. Clinical data, nerve conduction studies, and lower leg skin biopsies were collected from 22 BiPN patients. Skin sections were immunostained using anti-protein gene product 9.5 (PGP9.5) and calcitonin gene-related peptide (CGRP) antibodies. Cumulative bortezomib dose and clinical assessment scales indicated light-moderate sensory neuropathy. Pain intensity >4 (numerical rating scale) was present in 77% of the patients. Median pain intensity and overall McGill Pain Questionnaire (MPQ) sum scores indicated moderate to severe neuropathic pain. Sural nerve sensory nerve action potentials were abnormal in 86%, while intraepidermal nerve fiber densities of PGP9.5 and CGRP were not significantly different from healthy controls. However, subepidermal nerve fiber density (SENFD) of PGP9.5 was significantly decreased and the axonal swelling ratio, a predictor of neuropathy, and upper dermis nerve fiber density (UDNFD) of PGP9.5, presumably representing sprouting of parasympathetic fibers, were significantly increased in BiPN patients. Finally, significant correlations between UDNFD of PGP9.5 versus the evaluative Pain Rating Index (PRI) and number of words count (NWC) of the MPQ, and significant inverse correlations between SENFD/UDNFD of CGRP versus the sensory-discriminative MPQ PRI/NWC were found. BiPN is a sensory neuropathy, in which neuropathic pain is the most striking clinical finding. Bortezomib-induced neuropathic pain may be driven by sprouting of parasympathetic fibers in the upper dermis and impaired regeneration of CGRP fibers in the subepidermal layer.
The Dipeptidyl Peptidase 4 Substrate CXCL12 Has Opposing Cardiac Effects in Young Mice and Aged Diabetic Mice Mediated by Ca2+ Flux and Phosphoinositide 3-Kinase γ

Blood glucose–lowering therapies can positively or negatively affect heart function in type 2 diabetes, or they can have neutral effects. Dipeptidyl peptidase 4 (DPP-4) inhibitors lower blood glucose by preventing the proteolytic inactivation of glucagon-like peptide 1 (GLP-1). However, GLP-1 is not the only peptide substrate of DPP-4. Here, we investigated the GLP-1–independent cardiac effects of DPP-4 substrates. Pointing to GLP-1 receptor (GLP-1R)–independent actions, DPP-4 inhibition prevented systolic dysfunction equally in pressure-overloaded wild-type and GLP-1R knockout mice. Likewise, DPP-4 inhibition or the DPP-4 substrates substance P or C-X-C motif chemokine ligand 12 (CXCL12) improved contractile recovery after no-flow ischemia in the hearts of otherwise healthy young adult mice. Either DPP-4 inhibition or CXCL12 increased phosphorylation of the Ca2+ regulatory protein phospholamban (PLN), and CXCL12 directly enhanced cardiomyocyte Ca2+ flux. In contrast, hearts of aged obese diabetic mice (which may better mimic the comorbid patient population) had diminished levels of PLN phosphorylation. In this setting, CXCL12 paradoxically impaired cardiac contractility in a phosphoinositide 3-kinase γ–dependent manner. These findings indicate that the cardiac effects of DPP-4 inhibition primarily occur through GLP-1R–independent processes and that ostensibly beneficial DPP-4 substrates can paradoxically worsen heart function in the presence of comorbid diabetes.
BLTR1 in Monocytes Emerges as a Therapeutic Target For Vascular Inflammation With a Subsequent Intimal Hyperplasia in a Murine Wire-Injured Femoral Artery

Given the importance of high-mobility group box 1 (HMGB1) and 5-lipoxygenase (5-LO) signaling in vascular inflammation, we investigated the role of leukotriene signaling in monocytes on monocyte-to-macrophage differentiation (MMD) induced by HMGB1, and on vascular inflammation and subsequent intimal hyperplasia in a mouse model of wire-injured femoral artery. In cultured primary bone marrow-derived cells (BMDCs) stimulated with HMGB1, the number of cells with macrophage-like morphology was markedly increased in association with an increased expression of CD11b/Mac-1, which were attenuated in cells pre-treated with Zileuton, a 5-LO inhibitor as well as in 5-LO-deficient BMDCs. Of various leukotriene receptor inhibitors examined, which included leukotriene B4 receptors (BLTRs) and cysteinyl leukotriene receptors (cysLTRs), the BLTR1 inhibitor (U75302) exclusively suppressed MMD induction by HMGB1. The importance of BLTR1 in HMGB1-induced MMD was also observed in BMDCs isolated from BLTR1-deficient mice and BMDCs transfected with BLTR1 siRNA. Although leukotriene B4 (LTB4) had minimal direct effects on MMD in control and 5-LO-deficient BMDCs, MMD attenuation by HMGB1 in 5-LO-deficient BMDCs was significantly reversed by exogenous LTB4, but not in BLTR1-deficient BMDCs, suggesting that LTB4/BLTR1-mediated priming of monocytes is a prerequisite of HMGB1-induced MMD. In vivo, both macrophage infiltration and intimal hyperplasia in our wire-injured femoral artery were markedly attenuated in BLTR1-deficient mice as compared with wild-type controls, but these effects were reversed in BLTR1-deficient mice transplanted with monocytes from control mice. These results suggest that BLTR1 in monocytes is a pivotal player in MMD with subsequent macrophage infiltration into neointima, leading to vascular remodeling after vascular injury.
Learning behavioral context recognition with multi-stream temporal convolutional networks

Smart devices of everyday use (such as smartphones and wearables) are increasingly integrated with sensors that provide immense amounts of information about a person's daily life such as behavior and context. The automatic and unobtrusive sensing of behavioral context can help develop solutions for assisted living, fitness tracking, sleep monitoring, and several other fields. Towards addressing this issue, we raise the question: can a machine learn to recognize a diverse set of contexts and activities in a real-life through joint learning from raw multi-modal signals (e.g. accelerometer, gyroscope and audio etc.)? In this paper, we propose a multi-stream temporal convolutional network to address the problem of multi-label behavioral context recognition. A four-stream network architecture handles learning from each modality with a contextualization module which incorporates extracted representations to infer a user's context. Our empirical evaluation suggests that a deep convolutional network trained end-to-end achieves an optimal recognition rate. Furthermore, the presented architecture can be extended to include similar sensors for performance improvements and handles missing modalities through multi-task learning without any manual feature engineering on highly imbalanced and sparsely labeled dataset.
Embedded Pilot-Aided Channel Estimation for OTFS in Delay–Doppler Channels

Orthogonal time frequency space (OTFS) modulation was shown to provide significant error performance advantages over orthogonal frequency division multiplexing (OFDM) in delay–Doppler channels. In order to detect OTFS modulated data, the channel impulse response needs to be known at the receiver. In this paper, we propose embedded pilot-aided channel estimation schemes for OTFS. In each OTFS frame, we arrange pilot, guard, and data symbols in the delay–Doppler plane to suitably avoid interference between pilot and data symbols at the receiver. We develop such symbol arrangements for OTFS over multipath channels with integer and fractional Doppler shifts, respectively. At the receiver, channel estimation is performed based on a threshold method and the estimated channel information is used for data detection via a message passing algorithm. Thanks to our specific embedded symbol arrangements, both channel estimation and data detection are performed within the same OTFS frame with minimum overhead. We compare through simulations the error performance of OTFS using the proposed channel estimation and OTFS with ideally known channel information and observe only a marginal performance loss. We also demonstrate that the proposed channel estimation in OTFS significantly outperforms OFDM with known channel information. Finally, we present extensions of the proposed schemes to multiple-input multiple-output (MIMO) and multi-user uplink/downlink.
Non-periodic Tiling of Procedural Noise Functions

Procedural noise functions have many applications in computer graphics, ranging from texture synthesis to atmospheric effect simulation or to landscape geometry specification. Noise can either be precomputed and stored into a texture, or evaluated directly at application runtime. This choice offers a tradeoff between image variance, memory consumption and performance. Advanced tiling algorithms can be used to decrease visual repetition. Wang tiles allow a plane to be tiled in a non-periodic way, using a relatively small set of textures. Tiles can be arranged in a single texture map to enable the GPU to use hardware filtering. In this paper, we present modifications to several popular procedural noise functions that directly produce texture maps containing the smallest complete Wang tile set. The findings presented in this paper enable non-periodic tiling of these noise functions and textures based on them, both at runtime and as a preprocessing step. These findings also allow decreasing repetition of noise-based effects in computer-generated images at a small performance cost, while maintaining or even reducing the memory consumption.
Mobile farm for software testing

We introduce an approach to user interface testing with a particular focus on non-native GUI based mobile applications. We particularly address the domain of entertainment and education software including mobile games. We describe a prototype system based on inexpensive components and open source software, intended to support product development cycle for companies on lean budget. On the base of a prototype system discussed in this paper we expect to develop a distributed infrastructure that would allow users to use facilities of users' own computers and connected devices as a part of a common testing framework. The approach presented in this work is also suitable for wider range of mobile applications with a high variety of human-computer interaction mechanisms.
Toward the prevention of alcohol use disorders: Overdrinking (unintentional binge drinking) in a community sample

Approximately 64,000,000 people in the United States report binge drinking at least once in the past month. Unlike overeating and oversleeping, “overdrinking”—defined as drinking more than a person intends to drink—does not exist in the literature. Terms such as binge and problem drinking do not consider the intent of the drinker. The results of this pilot study suggest that most people drink more than they intend to drink. Moreover, they also report often being surprised that they overdrank. Smartphones may help overdrinkers be less often surprised by overdrinking and may prevent drinkers from developing an alcohol use disorder.
Response to joint selection on germination and flowering phenology depends on the direction of selection

Abstract Flowering and germination time are components of phenology, a complex phenotype that incorporates a number of traits. In natural populations, selection is likely to occur on multiple components of phenology at once. However, we have little knowledge of how joint selection on several phenological traits influences evolutionary response. We conducted one generation of artificial selection for all combinations of early and late germination and flowering on replicated lines within two independent base populations in the herb Campanula americana. We then measured response to selection and realized heritability for each trait. Response to selection and heritability were greater for flowering time than germination time, indicating greater evolutionary potential of this trait. Selection for earlier phenology, both flowering and germination, did not depend on the direction of selection on the other trait, whereas response to selection to delay germination and flowering was greater when selection on the other trait was in the opposite direction (e.g., early germination and late flowering), indicating a negative genetic correlation between the traits. Therefore, the extent to which correlations shaped response to selection depended on the direction of selection. Furthermore, the genetic correlation between timing of germination and flowering varies across the trait distributions. The negative correlation between germination and flowering time found when selecting for delayed phenology follows theoretical predictions of constraint for traits that jointly determine life history schedule. In contrast, the lack of constraint found when selecting for an accelerated phenology suggests a reduction of the covariance due to strong selection favoring earlier flowering and a shorter life cycle. This genetic architecture, in turn, will facilitate further evolution of the early phenology often favored in warm climates.