Miracle-dz/UniFAR-FTUs huggingface dataset:
Prediction of Tyr Residues Involved in Autophosphorylation of FLT3 Positive Leukemias

FLT3 is a receptor tyrosine kinase (RTK) expressed and activated in the majority of acute myeloid leukemia (AML) patients and also expressed in some normal hematopoietic cell types. At the cellular level, FLT3 /FLK2 transcripts have been detected in hematopoietic stem cell-enriched human and murine subpopulations. The ligand binding to extracellular domains results in autophosphorylation of intracellular Tyr residues in FLT3 followed by triggering the signal transduction in most of the AML cases. No Tyr residue that are phosphorylated to initiate signal transduction events in many types of leukemias has been mapped so far. On the basis of prediction of phosphorylation potential of Tyr in kinase activation domain of FLT3 we describe the possible Tyr sites involved in eliciting the down signal transductional events in leukemias.
The Combat Myth in the Book of Revelation

O livro de Adela Collins foi publicado primeiramente em 1976 pela Harvard Theological Review, e reimpresso com poucas mudanças em 2001. Na verdade, ele é a sua tese doutoral, defendida em setembro de 1975, sob a orientação de Dieter Georgi. O texto agora resenhado tem poucos acréscimos ao primeiro, mais no campo das referências. Esta presente resenha é uma saudação a essa nova edição da obra, que se tornou referência no estudo do Apocalipse de João. Para demonstrar sua tese, de que o Apocalipse tem como estrutura os antigos mitos de combate, Collins escolheu o Apocalipse 12 como fonte para análise, selecionado por ser mais o mais amplo e claro exemplo dessa dependência estrutural. A origem do material deste capítulo do livro de João está essencialmente no mito de combate, adaptado para interpretar uma situação de conflito e de perseguição do autor e das comunidades de crentes. Como resposta a essa situação, o Apocalipse advoga a estratégia da não-violência e do martírio idealizado. Segundo a autora, a maior dificuldade na análise do Apocalipse está no fato de várias passagens serem paralelas e repetidas. Isso indicaria o uso de fontes? Se refeririam aos mesmos eventos ou a eventos paralelos? Geralmente, os estudiosos apontam duas estratégias para resolver essa questão. Uma delas é admitir que o redator do Apocalipse usou farto número de fontes diferentes; a outra é entender que esse fenômeno é fruto da sua intenção literária deliberada. Esta segunda opção é chamada de Teoria da Recapitulação. Apesar dessa hipótese retroceder a datas tão antigas quanto Agostinho, ela foi eclipsada pela Teoria das Fontes, segundo a qual o autor de Apocalipse foi simplesmente um editor que compilou diversas fontes num único documento. Neste caso, as repetições seriam um critério para discernir os limites e extensões dessas fontes. Para Adela Collins, entretanto, a fraqueza dessa teoria reside na
Kinetic and Mechanistic Studies of Oxidation of an Antiallergic Drug with Bromamine-T in Acid and Alkaline Media

Cetrizine dihydrochloride (CTZH) is widely used as an anti-allergic drug. Sodium N-bromo-p-toluenesulfonamide or bromamine-T (BAT) is the bromine analogue of chloramine-T (CAT) and is found to be a better oxidizing agent than CAT. In the present research, the kinetics of oxidation of CTZH with BAT in acid and alkaline media was studied at 313 K. The experimental rate laws obtained are: -d[BAT]/dt= in acid medium and -d[BAT]/dt= in alkaline medium where PTS is p-toluenesulfonamide. Activation parameters and reaction constants were evaluated. The solvent isotope effect was studied using . The dielectric effect is positive. The stoichiometry of the reaction was found to be 1:1 and the oxidation products were identified as 4-chlorobenzophenone and (2-piperazin-1-yl-ethoxy)-acetic acid in both media. The rate of oxidation of CTZH is faster in acid medium. Suitable mechanisms and related rate laws have been worked out.
Mindfulness and Burnout in Elite Junior Athletes: The Mediating Role of Experiential Avoidance

Previous research suggests that mindfulness and experiential avoidance are negatively and positively related to athlete burnout, respectively. It is unknown, however, whether experiential avoidance functions as a mediator between mindfulness and athlete burnout. To address this gap, 387 elite Chinese junior athletes (M = 15.44 years, SD = 1.42) completed self-report measures of mindfulness, experiential avoidance, and athlete burnout. Findings provided cross-sectional evidence that experiential avoidance mediated the inverse association from mindfulness to each of the three burnout dimensions. No gender difference of these indirect effects was revealed. This study is the first to test the theoretical sequence in which mindfulness is associated with athlete burnout via experiential avoidance and provide additional support the adaptive nature of mindfulness.
Precise calculation of neutron-capture reactions contribution in energy release for different types of VVER-1000 fuel assemblies

Precise calculation of energy release in a nuclear reactor is necessary to obtain the correct spatial power distribution and predict characteristics of burned nuclear fuel. In this work, previously developed method for calculation neutron-capture reactions – capture component – contribution in effective energy release in a fuel core of nuclear reactor is discussed. The method was improved and implemented to the different models of VVER-1000 reactor developed for MCU 5 and MCNP 4 computer codes. Different models of equivalent cell and fuel assembly in the beginning of fuel cycle were calculated. These models differ by the geometry, fuel enrichment and presence of burnable absorbers. It is shown, that capture component depends on fuel enrichment and presence of burnable absorbers. Its value varies for different types of hot fuel assemblies from 3.35% to 3.85% of effective energy release. Average capture component contribution in effective energy release for typical serial fresh fuel of VVER-1000 is 3.5%, which is 7 MeV/fission. The method will be used in future to estimate the dependency of capture energy on fuel density, burn-up, etc.
Coarse-grained description of a passive scalar

The issue of the parameterization of small-scale dynamics is addressed in the context of passive-scalar turbulence. The basic idea of our strategy is to identify dynamical equations for the coarse-grained scalar dynamics starting from closed equations for two-point statistical indicators. With the aim of performing a fully-analytical study, the Kraichnan advection model is considered. The white-in-time character of the latter model indeed leads to closed equations for the equal-time scalar correlation functions. The classical closure problem however still arises if a standard filtering procedure is applied to those equations in the spirit of the large-eddy-simulation strategy. We show both how to perform exact closures and how to identify the corresponding coarse-grained scalar evolution.
3-D seismic attributes using a semblance‐based coherency algorithm

Seismic coherency is a measure of lateral changes in the seismic response caused by variation in structure, stratigraphy, lithology, porosity, and the presence of hydrocarbons. Unlike shaded relief maps that allow 3-D visualization of faults and channels from horizon picks, seismic coherency operates on the seismic data itself and is therefore unencumbered by interpreter or automatic picker biases. We present a more robust, multitrace, semblance-based coherency algorithm that allows us to analyze data of lesser quality than our original three-trace cross-correlation-based algorithm. This second-generation, semblance-based coherency algorithm provides improved vertical resolution over our original zero mean crosscorrelation algorithm, resulting in reduced mixing of overlying or underlying stratigraphic features. In general, we analyze stratigraphic features using as narrow a temporal analysis window as possible, typically determined by the highest usable frequency in the input seismic data. In the limit, one may confidently apply our new semblance-based algorithm to a one-sample-thick seismic volume extracted along a conventionally picked stratigraphic horizon corresponding to a peak or trough whose amplitudes lie sufficiently above the ambient seismic noise. In contrast, near-vertical structural features, such as faults, are better enhanced when using a longer temporal analysis window corresponding to the lowest usable frequency in the input data. The calculation of reflector dip/azimuth throughout the data volume allows us to generalize the calculation of conventional complex trace attributes (including envelope, phase, frequency, and bandwidth) to the calculation of complex reflector attributes generated by slant stacking the input data along the reflector dip within the coherency analysis window. These more robust complex reflector attribute cubes can be combined with coherency and dip/azimuth cubes using conventional geostatistical, clustering, and segmentation algorithms to provide an integrated, multiattribute analysis.
Temporal changes in photoreactivity of dissolved organic carbon and implications for aquatic carbon fluxes from peatlands

Abstract. Aquatic systems draining peatland catchments receive a high loading of dissolved organic carbon (DOC) from the surrounding terrestrial environment. Whilst photo-processing is known to be an important process in the transformation of aquatic DOC, the drivers of temporal variability in this pathway are less well understood. In this study, 8 h laboratory irradiation experiments were conducted on water samples collected from two contrasting peatland aquatic systems in Scotland: a peatland stream and a reservoir in a catchment with high percentage peat cover. Samples were collected monthly at both sites from May 2014 to May 2015 and from the stream system during two rainfall events. DOC concentrations, absorbance properties and fluorescence characteristics were measured to investigate characteristics of the photochemically labile fraction of DOC. CO2 and CO produced by irradiation were also measured to determine gaseous photoproduction and intrinsic sample photoreactivity. Significant variation was seen in the photoreactivity of DOC between the two systems, with total irradiation-induced changes typically 2 orders of magnitude greater at the high-DOC stream site. This is attributed to longer water residence times in the reservoir rendering a higher proportion of the DOC recalcitrant to photo-processing. During the experimental irradiation, 7 % of DOC in the stream water samples was photochemically reactive and direct conversion to CO2 accounted for 46 % of the measured DOC loss. Rainfall events were identified as important in replenishing photoreactive material in the stream, with lignin phenol data indicating mobilisation of fresh DOC derived from woody vegetation in the upper catchment. This study shows that peatland catchments produce significant volumes of aromatic DOC and that photoreactivity of this DOC is greatest in headwater streams; however, an improved understanding of water residence times and DOC input–output along the source to sea aquatic pathway is required to determine the fate of peatland carbon.
The Influence of Cattle Grazing on Pocket Gophers in the Central Sierra Nevada Mountains, California: Potential Implications for Great Gray Owls

Abstract Great Gray Owls (Strix nebulosa) in the Sierra Nevada Mountains feed primarily on rodents, especially voles and pocket gophers. Voles have been shown to be negatively affected by cattle grazing, but effects of grazing on gophers in the Sierra Nevada Mountains are unknown. We investigated the effects of grazing on pocket gophers (Thomomys monticola and T. bottae) in 21 grazed and 21 ungrazed montane meadow sites in the central Sierra Nevada Mountains of California. Pocket gopher densities were significantly higher in grazed meadows than ungrazed meadows. Vegetation cover and height, thatch depth, and the frequency of sedge occurrence were higher in ungrazed meadows and there were negative correlations between pocket gopher densities and these vegetation variables. We suggest that potential negative effects of grazing on Great Gray Owls could be minimized by managing meadow vegetation commensurate with the habitat needs of their prey.
Isolation and Identification of Some Pathogenic Bacteria from Otitis Media in Babylon Governorate

This study was conducted for the period from February to November 2016 in Babylon Teaching Hospital , during this period, 200 swab ear of people with otitis media in the city of Babylon were collected . 120 sample was diagnosed with bacterial isolates depending on morphology on the different culture media and some biochemical tests. The highest rate of infection in the age group (21-40)years , and the least in the age group (41-60)years as it was(46 %,15%)respectively. In this study were isolate five types of a bacteria (Pseudomonas aeruginosa, Staphylococcus aureus , Escherichia coli, Streptococcus pneumonia and Klebsiella pneumonia) and the highest rate of infection has reached (35 %, Pseudomonas aeruginosa), ( 26%,Staphylococcus aureus). As for the results of examination of the sensitivity of the bacterial isolates to antibiotics was the highest rate of antibiotic resistance was (94%Tetracyclin, 92%Ampicilin and 91% Chloramphenicol), while the resistance decreased in the case of antibiotics (42%Amikacin, 42%Gentamicin and 31%Tobramycin). Streptococcus pneumonia were detected by PCR , 16 cases were PCR positive for Streptococcus pneumonia , there was no samples displayed culture positive and PCR negative for Streptococcus pneumonia . Keywords: Pathogenic bacteria, Otitis media, Sensitivity test , PCR.
Experience of OSCE in faculty of medicine, Alzaeim Alazhari University, Sudan

Background: The traditional classical clinical exam (CCE) has limitations in terms of validity and reliability. Nowadays the Objective Structured Clinical Examination (OSCE) is widely used to assess the clinical pe rformance of medical students. Objective : To reflect and share the experience of OSCE exams in clinical departments in the Faculty of Medicine, Alzaeim Alazhari University (AAU) and to encourage more modifications to improve its quality. Material and Methodology: Data regarding clinical assessment; OSCEs versus cl assical clinical examinations was collected from faculty records. Th e collected data was entered computer and managed statistically using SPSS version 21. Results: Overall in the group of students examined by OSCE 67.7% rewarded grade B and above, whereas in the contrary 60.5% of students in CCE rewarded grade C+ and below, this difference was statistically significant (p=0.002). Conclusion: OSCE is an excellent tool, and fair to the students , as all examiners use the same check lists provided by the department . Students tend to do better in the clinical part of the examination when this type of assessment is used.
Patent Commercialization Strategy and IPO Underpricing: Evidence from the US Semiconductor Industry

R&D and innovation are critical factors to succeed. Nevertheless, they generate information asymmetries between corporate insiders and external investors. Within the context of an IPO, information asymmetries increase the risk of underpricing. In this paper, we claim that the patent commercialization strategy of the firm going public affects information asymmetries and IPO underpricing. In particular, underpricing will be higher when a firm’s patent commercialization strategy is more based on licenses. A firm’s stock of patent attenuates this effect. Our results on a sample of 130 IPOs in the US semiconductor industry confirm these predictions.
Effects of family functioning and family hardiness on self-efficacy among college students

Family functioning has been related to numerous developmental problems. Although there are other factors affecting a student? s self-efficacy, this research focused on the effects of family functioning and family hardiness. The implications that family functioning plays a great role in shaping one? s self belief systems will help to emphasize the need to resolve a growing cycle of social issues. The objectives of this study is to find out whether family functioning and family hardiness will have an influence on students? self-efficacy and also to determine the level of difference in self-efficacy of male and female students. Participants involved in this study were made up of a random sample of 120 students from a few colleges in the state of Selangor. Results obtained from this research study showed that there is a correlation amongst all three variables used, namely, family functioning, family hardiness and self-efficacy are interrelated. In addition, the results also showed that more males than females have been categorized in the category of clinical group for family functioning and selfefficacy.
Quantitative Proteomic Analysis of Skeletal Muscle Detergent- Resistant Membranes in a Smith-Lemli-Opitz Syndrome Mouse

The authors are thankful to Prof Forbes D. Porter and Doctor Christopher A. Wassif from NIH who kindly provided the genetically modified mice model of SLOS used in this investigation. FDP and CAW are supported by the intramural research program of 30 the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Requimte received finnantial support from the European Union (FEDER funds POCI/01/0145/ FEDER/007265) and National Funds (FCT/MEC, Fundacao para a Ciencia e Tecnologia and Ministerio da Educacao e Ciencia) under the Partnership Agreement PT2020 UID/QUI/50006/2013. This work received financial support from FCT/MEC through national funds and co-financed by FEDER, under the Partnership Agreement PT2020 (UID/MULTI/04378/2013 – POCI/01/0145/ FERDER/007728).
Dark respiration of pines

Plant respiration is a large, environmentally sensitive component of the carbon balance for pine ecosystems and can consume >60% of the carbon fixed in photosynthesis. If climate, genetics, or carbon allocation affect the balance between assimilation and respiration, respiration will affect net production. Respiration rates for tissues within a tree vary with the number of living cells and their metabolic activity. For pines, foliage and fine roots have similar respiration rates, with rates for seedlings (60 420 nmol C (mol C biomass)-1 s-1 at 15? C) higher than those for mature trees (20 70 nmol C (mol C biomass)-1 s-1 at 15? C). Woody tissue respiration is low compared with other tissues (<10 nmol C (mol C biomass)-1 s-1 at 15? C, for dormant large stems; and 4-60 nmol C (mol C biomass)-1 s-1 at 15? C, for small stems, branches, twigs and coarse roots). Reported annual total respiration for the living parts of pine trees uses 32-64% of the annual total of net daytime carbon fixation. The ratio of annual respiration to photosyn thesis increased linearly with stand biomass for young pine stands. Simulations of respiration and assimilation for Pinus elliottii and P. contorta forests support the hypothesis that pines growing in warmer climates have lower leaf area index because temperature shifts the canopy compensation point. Simulations of these same stands with increased air temperature in situ suggest that pines growing in cool climates might offset increased foliar respiration and maintain assimilation by reducing leaf area. Future research on the role of respiration in forest productivity should concentrate on producing annual budgets at the stand level.
Variability of Scots pine (Pinus sylvestris L.) called Tabórz pine (Forest District Miłomłyn) expressed in analysis of morphology of needle traits and polymorphism of microsatellite DNA

Abstract Scots pine (Pinus sylvestris L.) is one of the most widespread forest trees in the world, ranging from southern Mediterranean mountains to eastern Siberia. 30 trees of Scots pine from the Miłomłyn Forest District were analyzed in terms of 7 nuclear and 8 chloroplast microsatellite DNA loci as well as 7 morphological needle traits. Nuclear microsatellites (Simple Sequence Repeats) have proved to be useful in studying phylogeographic and gene flow patterns in conifers and are being used to infer the demographic history of tree species. A population’s genetic diversity, in fact, represents an important criterion which could be applied in planning future forest management and breeding. Additionally, many elements of Scots pine morphology, including needle traits, are subject to environmental modification. However, the adaptability of those traits remains, to some extent, under genetic control. The trees we investigated here are called Tabórz pine located in the northeast of Poland. This population is described as one of the best in Poland and even in Europe regarding bio mass production, ductility and wood quality. The aim of the study was to determine variation and genetic structure within this population. An analysis of phenotypic differentiation showed that the traits which differed the most between individuals were needle length, the number of serrations per 2 mm of needle length along the right edge and the number of stomatal rows on the convex side of the needles. In Tabórz pine, we detected 30 different genotypes with 87 alleles as well as 28 haplotypes with 30 alleles. We also revealed a slight excess of homozygotes, but the population is still in Hardy-Weinberg equilibrium. The Scots pine population from Tabórz furthermore showed a higher level of genetic diversity compared to stands from other Polish and European regions. This diversity may be the main factor impacting on the population’s wood quality and its breeding value.
Active Cooperative Observation of A 3D Moving Target Using Two Dynamical Monocular Vision Sensors

Vision‐based 3D moving target observation (3D‐VMTO) is a central problem in the field of mobile robotics. In this paper, a new 3D‐VMTO method called active cooperative observation is proposed through cooperation among two dynamical monocular vision sensors (MVSs). Under this method, an algorithm based on an extended set‐membership filter is designed to fuse observations from different MVSs. An optimal observation condition is then introduced as the constraint into the relative velocity coordinates based path planning scheme, so as to reduce the influence of relative positioning among MVSs and their target on cooperative observation results. Experiments on a multiple rotor‐flying‐robots testbed demonstrate the validity and feasibility of the proposed method.
The Effect of Stress on the Ecology of Neospora caninum in Bison (Bison bison)

ii Dedication . iv Acknowledgements . v Vita . vi List of Tables . x List of Figures . xii Chapter 1: Literature Review . 1 1.1: Introduction . 1 1.2: Stress Response . 2 1.3: Stress and Reproduction . 4 1.4: Immunology . 8 1.5: Stress and Immunology . 9 1.6: Introduction to Neospora caninum . 15 1.7: N. caninum's economic impact and prevalence . 16 1.8: Transmission of N. caninum . 18 1.9: Diagnosis of N. caninum . 20 viii 1.10: N. caninum Pathogenesis . 22 Chapter 2: Methods . 33 2.1: Animals and Study Area . 33 2.2: Sample Collection . 34 2.3: Fecal Corticostreone Determination . 35 2.4: ACTH Challenge . 36 2.5: Fecal Progesterone Determination . 36 2.6: Neospora caninum Antibody Titers . 37 2.7: Hematologic Diagnostics . 39 2.8: Pregnancy Diagnosis and Neonatal tissue Diagnostics . 40 2.9: Statistical Analysis . 41 Chapter 3: Results . 43 3.1: Validation of Corticosterone Assay . 43 3.2: Validation of Bovine cELISA for Use in Bison . 43 3.3: Influence of Study Group and Time on Fecal Corticosterone Levels . 44 3.4: Influence of Study Group on Fecal Progesterone Levels and Ultrasonography Diagnosis . 44