Miracle-dz/UniFAR-FTUs huggingface dataset:
Survey of Chinese Historical Syntax Part II: Middle Chinese

This is the second article in a two-part introduction to Chinese historical syntax. The previous article introduces aspects of pre-medieval grammar which differ markedly from modern Chinese varieties, specifically fronting of object NPs to preverbal position, the asymmetry between subject and object relative clause formation, and the encoding of argument structure alternations like active and passive. Each of these characteristics is related to morphological distinctions on nouns, verbs, or pronouns which are either overtly represented in the logographic writing system in Archaic Chinese or have been reconstructed for (Pre-)Archaic Chinese. In this second article, I discuss changes which took place in Middle Chinese and correlate these innovations with the loss of the (Pre-)Archaic Chinese morphology. The main goal of these articles is to highlight a common denominator, i.e. the morphology, which enables a systemic view of pre-medieval Chinese and the changes which have resulted in the striking differences observed in Middle Chinese and beyond.
The CORE‐OM and CORE‐OM (SV) in secure settings: a template analysis of the experiences of male patients and their staff

Purpose – The purpose of this paper is to establish staff and patient opinions on the acceptability, feasibility, and utility of using the Clinical Outcomes in Routine Evaluations – Outcome Measure (CORE‐OM) in secure hospitals.Design/methodology/approach – Patients and nurses (male patients and their key workers) from high, medium and low secure hospitals participated in semi‐structured interviews after completing CORE‐OM or CORE‐OM (SV). Findings – Template themes were acceptability, feasibility, relevance, suitability, changes to treatment, and understanding. Findings suggest that the CORE‐OM is acceptable and potentially useful in secure settings.Practical implications – This paper suggests that the CORE‐OM is acceptable to patients and staff in secure settings and appears to be a feasible measure for such settings. Further research and accumulation of a referential database of item scores is needed for PROMS, including the CORE‐OM, to be fully useful in secure settings.Originality/value – This paper w.
Glucose Pattern Management Teaches Glycemia-Related Problem-Solving Skills in a Diabetes Self-Management Education Program

In Brief Self-monitoring of blood glucose (SMBG) involves both the performance of glucose tests and glucose pattern management (GPM) and is a tool patients with diabetes can use to achieve their glucose goals. Seeing the effects that increased activity or modified carbohydrate intake can have on lowering glucose levels is a powerful motivator for patients and reinforces successful behaviors. This article describes how SMBG (including GPM) is integrated into a diabetes self-management education program to teach problem-solving skills and empower patients.
Updated long‐term survival for patients with metastatic colorectal cancer treated with liver resection followed by hepatic arterial infusion and systemic chemotherapy

Patients who undergo liver resection for metastatic colorectal cancer (mCRC) have reported 5‐year survivals ranging from 25% to 50%. The current study updated long‐term survival for patients with resected liver metastases treated with adjuvant hepatic arterial infusion (HAI) and systemic (SYS) chemotherapy.
COMPLEMENT AS A MEDIATOR OF INFLAMMATION

Interaction in free solution of highly purified preparations of human C'1 esterase, C'4, C'2, and C'3, in the presence of Mg2+, resulted in rapid generation of an activity indistinguishable by biological criteria from anaphylatoxin. The formation of anaphylatoxin was associated with immunoelectrophoretic conversion of C'3 to anodically faster migrating proteins and was unaffected by the presence or absence of added C'5. The biological properties of human anaphylatoxin prepared in this manner include: contraction and desensitization of isolated guinea pig ileum, failure to contract isolated rat uterus, enhancement of vascular permeability in guinea pig skin, degranulation of mast cells in guinea pig mesentery preparations, and liberation of histamine from suspensions of rat peritoneal mast cells. The smooth muscle-contracting and permeability enhancing properties were fully blocked by an antihistaminic drug, triprolidine. No cross-desensitizing activity on guinea pig ileum was demonstrable between rat and human or guinea pig and human anaphylatoxins but a closer biological relationship between rat and guinea pig anaphylatoxins was observed. It is concluded that anaphylatoxin is a product of the complement system. Its possible relationship to apparently similar activities currently being obtained in other laboratories has been discussed.
Establishment of micromethods for macronutrient contents analysis in breast milk.

Commercially available milk analysers were originally developed for use in the dairy industry, but they are now used to analyse macronutrient content of breast milk in clinical studies and routine care of the premature or very low birthweight (VLBW) infants. Due to the different composition of cow and breast milk, these devices need to be validated against reference methods before they can be used in daily routine. However, current reference methods require a sample volume of 30-100 mL to analyse fat, protein and lactose. It is not feasible to obtain this volume of milk for research purposes, especially from VLBW infants as lactation may be delayed or impaired and the limited volume of breast milk must be provided to the infant. To support validation of milk analysers in both clinical and research settings, the aim of this study is to establish and validate micromethods for precise macronutrient analysis in small volume of breast milk and conduct a feasibility study of the micromethods as a post-validation. Methods include a modified Mojonnier ether extraction (fat), elemental analysis (protein) and ultra-performance liquid chromatography-tandem mass spectrometry (lactose). We were able to downsize volumes required for analysis of fat, protein and lactose to 1 mL, 260 μL and 100 μL; corresponding coefficients of variation are 1.7, 1.8 and 2.3%, respectively. The presented methods allow for reliable and precise analyses of macronutrients in ≤1.5 mL of breast milk and will be used to validate milk analysers.
Aiming to be a breastfeeding mother in a neonatal intensive care unit and at home: a thematic analysis of peer-support group discussion in social media.

Preterm infants are usually breastfed less than full-term infants, and successful breastfeeding requires a supportive environment and special efforts from their mothers. A breastfeeding peer-support group, utilising social media, was developed for these mothers in order to support them in this challenge. Mothers were able to discuss breastfeeding and share experiences. The purpose of this study was to describe the perceptions of breastfeeding mothers of preterm infants based on the postings in peer-support group discussions in social media. The actively participating mothers (n = 22) had given birth <35 gestational weeks. They were recruited from one university hospital in Finland. The social media postings (n = 305) were analysed using thematic analysis. A description of the process of breastfeeding a preterm infant from the point of view of a mother was created. The process consisted of three main themes: the breastfeeding paradox in hospital, the 'reality check' of breastfeeding at home and the breastfeeding experience as part of being a mother. The mothers encountered paradoxical elements in the support received in hospital; discharge was promoted at the expense of breastfeeding and pumping breast milk was emphasised over breastfeeding. After the infant's discharge, the over-optimistic expectations of mothers often met with reality - mothers did not have the knowledge or skills to manage breastfeeding at home. Successful breastfeeding was an empowering experience for the mothers, whereas unsuccessful breastfeeding induced feelings of disappointment. Therefore, the mothers of preterm infants need evidence-based breastfeeding counselling and systematic support in a neonatal intensive care unit (NICU) and at home.
Alicyclobacillus consociatus sp. nov., isolated from a human clinical specimen.

A Gram-stain-positive, aerobic organism, isolated from a blood sample from a 51-year-old woman, was studied for its taxonomic position. Based on 16S rRNA gene sequence similarity comparisons, strain CCUG 53762(T) was grouped into the genus Alicyclobacillus, most closely related to the type strain of Alicyclobacillus pohliae (94.7 %). The 16S rRNA gene sequence similarity to other species of the genus Alicyclobacillus was ≤91 % and similarity to species of the genus Tumebacillus was 91.3-93 %. The occurrence of menaquinone MK-7 as the major respiratory quinone, meso-diaminopimelic acid as the diagnostic diamino acid of the cell wall and the fatty acid profile supported the allocation of the strain to the genus Alicyclobacillus. Major fatty acids were iso- and anteiso-branched fatty acids. The polar lipid profile consisted of diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine and three unknown phospholipids. The absence of the iso-branched fatty acids iso-C16 : 0 and iso-C17 : 0 allowed differentiation of strain CCUG 53762(T) from A. pohliae CIP 109385(T). In addition, the results of physiological and biochemical tests also allowed phenotypic differentiation of strain CCUG 53762(T) from this most closely related species. The G+C content of the DNA was 47 mol%. Strain CCUG 53762(T) therefore represents a novel species of the genus Alicyclobacillus, for which we propose the name Alicyclobacillus consociatus sp. nov., with CCUG 53762(T) ( = CCM 8439(T)) as the type strain.
Computerised static posturography in neurology

Posturography is a general term for techniques used to measure postural stability on static or dynamic measuring platforms. The principle of static computerised posturography (SCPG) is the detection of the centre of foot pressure (CFP) in upright stance on a posturography platform. Our communication deals with the importance of SCPG in differential topodiagnosis of vestibular syndromes in neurology. The set of examinations and evaluations carried out was divided among a control group of healthy subjects (77), a group of subjects with peripheral vestibular disorder (159), and a group of subjects with a non-peripheral balance disorder (82). Results obtained through the measurements were evaluated using descriptive statistics procedures and basic numerical and graphic statistical characteristics of the given groups. Our observations demonstrate that posturography is a valuable auxiliary test for balance disorders, especially given the lack of more suitable tests. According to our results, SCPG can be used for a rough differential topodiagnosis of balance disorders in neurology.
The importance of mitotic rate reporting in primary cutaneous melanoma

Primary melanoma (M) mitotic rate (MR) is considered to be an important adverse predictor for overall survival: as the number of mitoses/mm increases, survival decreases. In multivariate analyses, MR was found to be the second powerful predictor of survival outcome, after Breslow’s thickness, in patients with localized M. On the basis of this evidence, the 7th edition of the American Joint Committee on Cancer (AJCC) staging manual adopted MR as T1 substaging criterion, replacing the Clark’s level (T1a: ≤1mm in thickness, mitosis <1/mm without ulceration; T1b: ≤1mm in thickness, mitoses ≥1/mm, and/or presence of ulceration). The 2009 Committee, in fact, concluded that the histologic diagnosis of all primary Ms should include a MR determination, using a standardized approach, the socalled “hot spot”method. In this regard, Lorimer et al. have examined 107 194 patients affected by M from 2010 to 2013; MR was reported in only 80 039 cases (74.7%). According to the Authors, for the remaining 27 155 patients, the lack of MR reporting can have important implications for proper staging and prognostication, arguing that with detailed pathological reports, clinicians may formulate more personalized and effective treatment plans. For this reason, further investigations of procedures performed in academic settings, which may influence reporting of MR, are warranted by the Authors. Surprisingly, the 8th edition of the AJCC cancer staging manual no longer considers MR as T1 sub-staging criterion, although it remains a major determinant for prognosis in all thickness categories. In fact, a sub-stratification of T1M has been achieved adopting a cut-off for the depth of invasion, that is 0.8 mm (T1a: <0.8 mm without ulceration; T1b <0.8 mm with ulceration; or 0.8–1mm with or without ulceration). The 2016 Committee has taken this decision by virtue of a stronger association with the clinical outcome. In our opinion, a biohistological approach allows to merge these different views. Two phases of M growth are scientifically recognized: the radial growth phase (RGP) and the vertical growth phase (VGP). Following this conception, T1 stage may be classified into three subtypes, listed below.
Falsochrobactrum ovis gen. nov., sp. nov., isolated from a sheep.

A Gram-stain-negative, rod-shaped, oxidase-positive, non-spore-forming, non-motile bacterium (B1315(T)) was isolated from the placenta of a sheep with abortion. On the basis of 16S rRNA gene sequence analyses the strain was assigned to the Brucella-Ochrobactrum-Paenochrobactrum-Pseudochrobactrum group with 94.5-94.8 %, 94.3-96.1 %, 95.0-95.1 %, and 95.9-96.1 % sequence similarities to type strains of species of the four genera, respectively. Phylogenetic trees indicated a close relationship to the type strains of Ochrobactrum gallinifaecis and Ochrobactrum oryzae (95.9 and 96.1 % sequence similarity, respectively). Chemotaxonomic data confirmed the allocation of strain B1315(T) to the family Brucellaceae (quinone system: ubiquinone Q-10 and major fatty acids: C18 : 1ω7c and C19 : 0 cyclo ω8c). The polar lipid profile contained the major lipids diphosphatidylglycerol, phosphatidylmonomethylethanolamine, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylcholine and the unidentified but unique phospholipid PL7. The polyamine pattern of strain B1315(T) contained the major polyamines spermidine and putrescine. On the basis of the 16S rRNA gene and recA sequence phylogeny and chemotaxonomic data strain B1315(T) was clearly different from the genera Brucella, Ochrobactrum, Paenochrobactrum and Pseudochrobactrum. On the basis of these data we propose the novel genus Falsochrobactrum gen. nov. with the type species Falsochrobactrum ovis sp. nov. with the type strain B1315(T) ( = CCM 8460(T) = LMG 27356(T.)) The taxonomic allocation of O. gallinifaecis, which grouped inconsistently together with strain B1315(T) on the basis of 16S rRNA gene sequence data, but shows the chemotaxonomic features of the genus Ochrobactrum, remains to be clarified.
Advancement of lung tissue engineering: an overview

Lung diseases can be classified as Chronic Obstructive Pulmonary Disorder (COPD), pulmonary fibrosis and sarcoidosis as well as lung cancer. Current conventional treatment therapies for lung diseases are associated with various drawbacks. The field of Tissue Engineering (TE) is relatively new discipline that offers the potential to create de novo structures and may grant substitutes to replace damaged organs and tissues. This review gives a brief account of lung diseases and debates the research findings as well as the recent developments of TE lung with particular emphasis on the regeneration of alveolar-like structures. Selection of cell sources and the use of biological and synthetic materials as extracellular matrix derivatives and exogenous simulations of tissue growth within specified Three Dimensional (3D) scaffold structures are presented and discussed. Moreover, the critical challenges involved in developing an alternative tissue engineering heart lung and the future directions are also given. Finally, the paper proposes a novel concept of “the breathing scaffold”, which could facilitate the growth of the cells into a 3D alveolar structure while maintaining their gas exchange.
Suboptimal maternal and cord plasma pyridoxal 5′ phosphate concentrations are uncommon in a cohort of Canadian pregnant women and newborn infants

Vitamin B6 is important in fetal development, but little is known of the vitamin B6 status of pregnant women and newborns in North America and potential modifying factors. This prospective study determined maternal and cord plasma concentrations of pyridoxal 5' phosphate (PLP; an indicator of vitamin B6 status) in a convenience sample of 368 Canadian pregnant women and their newborns. The association of maternal intake of vitamin B6 and fetal genetic variants with cord plasma PLP and homocysteine concentrations was also examined. Dietary and supplemental intakes of vitamin B6 were assessed in early and mid to late pregnancy. PLP concentrations were measured in maternal plasma in early pregnancy and at delivery, and in cord plasma. Six fetal variants of the MTHFR and CβS genes were assessed for their association with cord plasma PLP and homocysteine concentrations. Geometric mean (95% CI) PLP concentrations were 107 (98, 116) nmol/L in early pregnancy and 58 (53, 62) nmol/L at delivery, respectively, and 296 (275, 319) nmol/L in cord blood (p < .0001). During early pregnancy and at delivery, 3.6% and 5.5% of women had plasma PLP concentrations <20 nmol/L, respectively. Ninety eight percent of the women with supplemental B6 intake of at least the recommended dietary allowance had PLP concentrations >20 nmol/L. Fetal genetic variants were not associated with cord PLP and homocysteine concentrations. Vitamin B6 deficiency is uncommon in a cohort of Canadian pregnant women due largely to prevalent vitamin B6 supplement use.
Trends and predictors of appropriate complementary feeding practices in Nepal: An analysis of national household survey data collected between 2001 and 2014

Abstract There is evidence that suboptimal complementary feeding contributes to poor child growth. However, little is known about time trends and determinants of complementary feeding in Nepal, where the prevalence of child undernutrition remains unacceptably high. The objective of the study was to examine the trends and predictors of suboptimal complementary feeding in Nepali children aged 6–23 months using nationally representative data collected from 2001 to 2014. Data from the 2001, 2006, and 2011 Nepal Demographic and Health Surveys and the 2014 Multiple Indicator Cluster Survey were used to estimate the prevalence, trends and predictors of four WHO‐UNICEF complementary feeding indicators: timely introduction of complementary foods (INTRO), minimum meal frequency (MMF), minimum dietary diversity (MDD), and minimum acceptable diet (MAD). We used multilevel logistic regression models to identify independent factors associated with these indicators at the individual, household and community levels. In 2014, the weighted proportion of children meeting INTRO, MMF, MDD, and MAD criteria were 72%, 82%, 36% and 35%, respectively, with modest average annual rate of increase ranging from 1% to 2%. Increasing child age, maternal education, antenatal visits, and community‐level access to health care services independently predicted increasing odds of achieving MMF, MDD, and MAD. Practices also varied by ecological zone and sociocultural group. Complementary feeding practices in Nepal have improved slowly in the past 15 years. Inequities in the risk of inappropriate complementary feeding are evident, calling for programme design and implementation to address poor feeding and malnutrition among the most vulnerable Nepali children.
Nocardioides salsibiostraticola sp. nov., isolated from biofilm formed in coastal seawater.

A Gram-staining-positive, non-motile, aerobic, non-spore-forming and short rod-shaped bacterial strain, PAMC 26527(T), was isolated from biofilm formed in coastal seawater of the Norwegian Sea. Analysis of the 16S rRNA gene sequence of strain PAMC 26527(T) revealed a clear affiliation with the genus Nocardioides. Based on phylogenetic analysis, strain PAMC 26527(T) showed the closest phylogenetic relationship with Nocardioides caricicola YC6903(T) with 16S rRNA gene sequence similarity of 96.3 %. Strain PAMC 26527(T) grew in the presence of 0-5.0 % sea salts. The optimum temperature and pH for growth were 20 °C and pH 7.5. The major cellular fatty acids of strain PAMC 26527(T) were iso-C16 : 0, C17 : 1ω8c and C18 : 1ω9c and the major isoprenoid quinone was MK-8(H4). Cell-wall analysis showed that strain PAMC 26527(T) contained LL-diaminopimelic acid. The genomic DNA G+C content was 69.3 mol%. The combined phenotypic, chemotaxonomic and phylogenetic data showed that strain PAMC 26527(T) could be clearly distinguished from recognized members of the genus Nocardioides. Thus, strain PAMC 26527(T) should be classified as representing a novel species in the genus Nocardioides, for which the name Nocardioides salsibiostraticola sp. nov. is proposed. The type strain is PAMC 26527(T) ( = KCTC 29158(T) = JCM 18743(T)).
Genome‐wide RAD sequence data provide unprecedented resolution of species boundaries and relationships in the Lake Victoria cichlid adaptive radiation

Although population genomic studies using next generation sequencing (NGS) data are becoming increasingly common, studies focusing on phylogenetic inference using these data are in their infancy. Here, we use NGS data generated from reduced representation genomic libraries of restriction‐site‐associated DNA (RAD) markers to infer phylogenetic relationships among 16 species of cichlid fishes from a single rocky island community within Lake Victoria's cichlid adaptive radiation. Previous attempts at sequence‐based phylogenetic analyses in Victoria cichlids have shown extensive sharing of genetic variation among species and no resolution of species or higher‐level relationships. These patterns have generally been attributed to the very recent origin (<15 000 years) of the radiation, and ongoing hybridization between species. We show that as we increase the amount of sequence data used in phylogenetic analyses, we produce phylogenetic trees with unprecedented resolution for this group. In trees derived from our largest data supermatrices (3 to >5.8 million base pairs in width), species are reciprocally monophyletic with high bootstrap support, and the majority of internal branches on the tree have high support. Given the difficulty of the phylogenetic problem that the Lake Victoria cichlid adaptive radiation represents, these results are striking. The strict interpretation of the topologies we present here warrants caution because many questions remain about phylogenetic inference with very large genomic data set and because we can with the current analysis not distinguish between effects of shared ancestry and post‐speciation gene flow. However, these results provide the first conclusive evidence for the monophyly of species in the Lake Victoria cichlid radiation and demonstrate the power that NGS data sets hold to resolve even the most difficult of phylogenetic challenges.
Point of Practice: Keeping “Health” in Health Communication Research and Practice

A review of my research in health communication leads to the presentation of eight insights that may be applied to the practice of health communication. The significance of collaboration and work in health communication practice settings, ranging from public health departments, to clinics, to participation in the Institute of Medicine guides the discussion of three broad principles that inform my health communication research. In both cases, a core emphasis is given to keeping “health” in health communication research and practice.