Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of Physician-Defined Flares on Quality of Life and Work Impairment: An International Survey of 2238 Patients With Psoriatic Arthritis

Objective To describe psoriatic arthritis (PsA) flares and their effect on patient-reported outcomes (PROs). Methods Cross-sectional surveys of rheumatologists/dermatologists and their patients with PsA were conducted in France, Germany, Italy, Spain, the United Kingdom, and the United States, capturing data on physician-reported patient flare status, demographics, PsA severity, and clinical outcomes. Patient-completed surveys captured data on PROs: 5-level EuroQol 5-dimension, Work Productivity and Activity Impairment questionnaire, Health Assessment Questionnaire–Disability Index, and 12-item Psoriatic Arthritis Impact of Disease questionnaire. Patients were compared by flare status using parametric and nonparametric tests. Multivariate regression was used to identify flare associations. Multivariate logistic regression adjusted for patient demographics and physician specialty assessed the effect of flare status. Results Among 2238 patients (586 from the US, 1652 from Europe) managed by 572 physicians, physician-reported flare was present for 168 patients (7.5%), and self-reported flare was present for 95 patients (10% of available data). Mean (SD) flare count over 12 months was 2.2 (4.9), lasting on average 16.4 (16.2) days. Flare status was linked to worse PROs. Patients who had not flared in the last 12 months or had never flared had a higher quality of life, lower overall work impairment, and a lower degree of disability compared with patients who were currently experiencing a flare (all; P < 0.01). Conclusion Actively experiencing a flare adversely affected QOL, disability, and work productivity. PsA flares should be routinely assessed and managed in clinical care.
Draft Genome Sequence of Calonectria pteridis, the Causal Agent of Calonectria Leaf Blight on Eucalyptus

Here, we report the draft genome sequence of Calonectria pteridis, the causal agent of Calonectria leaf blight in eucalyptus plantations in Brazil. The 58,373,473-bp genome assembly consists of 1,167 scaffolds, with a GC content of 50.21%. These genomic data can contribute to future studies involving the biology, adaptability, and pathogenicity of C. pteridis. ABSTRACT Here, we report the draft genome sequence of Calonectria pteridis, the causal agent of Calonectria leaf blight in eucalyptus plantations in Brazil. The 58,373,473-bp genome assembly consists of 1,167 scaffolds, with a GC content of 50.21%. These genomic data can contribute to future studies involving the biology, adaptability, and pathogenicity of C. pteridis.
Articulatory and segmental performance in children with and without speech disorder: A multiple case pilot study

ABSTRACT This multiple case pilot study explored how nonword imitation influences articulatory and segmental performance in children with and without speech disorder. Eight children, ages 4- to 8-years-old, participated, including two children with childhood apraxia of speech (CAS), four children with phonological disorder (PD), and two children with typical development (TD). Tokens included two complexity types and were presented in random order. Minimal feedback was provided and nonwords were never associated with a referent. Kinematic and transcription data were analysed to examine articulatory variability, segmental accuracy, and segmental variability in session 1 and session 5. Descriptive statistics, percent change, effect sizes, and Pearson correlations are reported. In session 1, the two participants with CAS showed high articulatory variability, low segmental accuracy, and high segmental variability compared to the participants with PD and TD. By session 5, both participants with CAS, two with PD, and one with TD showed increased articulatory variability in the lowest complexity nonword. Segmental accuracy remained low and variability remained high for the two participants with CAS in session 5, whereas several participants with PD and TD showed improved segmental performance. Articulatory and segmental variability were not significantly correlated. The results of this study suggest that motor practice with minimal feedback and no assignment of a lexical referent can instantiate positive changes to segmental performance for children without apraxia. Positive changes to segmental performance are not necessarily related to increased articulatory control; these two processing levels can show distinct and disparate learning trajectories.
Thief Zone Assessment in Sandstone Reservoirs Based on Multi-Layer Weighted Principal Component Analysis

Many factors influence the evaluation process of thief zones. The evaluation index contains very complex information. How to quickly obtain effective information is the key to improve the evaluation quality for thief zones. Considering that the correlation and information redundancy among the evaluation indexes will seriously affect the evaluation results for the thief zone, based on the principal component analysis (PCA) method, this paper proposes a multi-layer weighted principal component analysis method (MLWPCA). Firstly, factor analysis is performed on the original data to obtain the plurality subsystems of the evaluation index. Then, a principal component is analyzed through the subsystems of the evaluation index PCA to obtain the principal component score. Finally, the subsystem is weighted by the factor score and the comprehensive thief zone score is obtained by combining the subsystem weight and the subsystem score. A case study on the Daqing oilfield shows the effectiveness of the method, verified by tracer tests when applying the MLWPCA method to evaluate the thief zone. The thief zone of the Daqing oilfield is obviously affected by effective thickness, coefficient of permeability variation and interwell connectivity. At present, there are 10 well developed thief zones and eight medium developed thief zones in Daqing oilfield. The accuracy of this method is 94.44%. Compared with PCA, this method has better pertinence in evaluating thief zones, and is more effective in determining the principle influencing factors.
Neurophysiological evidence for goal-oriented modulation of speech perception.

Speech perception depends on the dynamic interplay of bottom-up and top-down information along a hierarchically organized cortical network. Here, we test, for the first time in the human brain, whether neural processing of attended speech is dynamically modulated by task demand using a context-free discrimination paradigm. Electroencephalographic signals were recorded during 3 parallel experiments that differed only in the phonological feature of discrimination (word, vowel, and lexical tone, respectively). The event-related potentials (ERPs) revealed the task modulation of speech processing at approximately 200 ms (P2) after stimulus onset, probably influencing what phonological information to retain in memory. For the phonological comparison of sequential words, task modulation occurred later at approximately 300 ms (N3 and P3), reflecting the engagement of task-specific cognitive processes. The ERP results were consistent with the changes in delta-theta neural oscillations, suggesting the involvement of cortical tracking of speech envelopes. The study thus provides neurophysiological evidence for goal-oriented modulation of attended speech and calls for speech perception models incorporating limited memory capacity and goal-oriented optimization mechanisms.
Two-years antibody responses following SARS-CoV-2 infection in humans: A study protocol

The long-term antibody response to the novel SARS-CoV-2 in infected patients and their residential neighborhood remains unknown in Indonesia. This information will provide insights into the antibody kinetics over a relatively long period as well as transmission risk factors in the community. We aim to prospectively observe and determine the kinetics of the anti-SARS-CoV-2 antibody for 2 years after infection in relation to disease severity and to determine the risk and protective factors of SARS CoV-2 infections in the community. A cohort of RT-PCR confirmed SARS-CoV-2 patients (case) will be prospectively followed for 2 years and will be compared to a control population. The control group comprises SARS-CoV-2 non-infected people who live within a one-kilometer radius from the corresponding case (location matching). This study will recruit at least 165 patients and 495 controls. Demographics, community variables, behavioral characteristics, and relevant clinical data will be collected. Serum samples taken at various time points will be tested for IgM anti-Spike protein of SARS-CoV-2 and IgG anti-Spike RBD of SARS-CoV-2 by using Chemiluminescent Microparticle Immunoassay (CMIA) method. The Kaplan-Meier method will be used to calculate cumulative seroconversion rates, and their association with disease severity will be estimated by logistic regression. The risk and protective factors associated with the SARS-CoV-2 infection will be determined using conditional (matched) logistic regression and presented as an odds ratio and 95% confidence interval.
Chemoprofiling and insilico prioritization of bioactive compounds from Laetiporus versisporus (Lloyd) Imazeki reveals potential Bcl-2 inhibitor

Abstract Laetiporus versisporus (Lloyd) Imazeki is an edible mushroom that grows abundantly in kodaikanal hills (India) during rainy season. Till now, there is a dearth of reports on chemoprofile and anticancer potential of this mushroom. In our recent study, L.versisporus ethanolic extract was reported to confer hepato-protective activity against DEN-induced HCC rats and also found to downregulate Bcl-2 activity. Moreover, the phytocompounds of a related species namely, L. sulphurous is also reported to potentially modulate Bcl-2 in glioblastoma. Hence, by this study, the bioactive compounds from L. versisporus ethanolic extract were profiled using LC-MS analysis and were virtually screened against ligand binding site of Bcl-2 in order to predict potential moieties with anticancer efficacies. Further, the top 3 potential hits were shortlisted based on MMGBSA score, ADME properties and stable complex formation during MD simulation. Amongst these hits, (6S)-1alpha, 25-dihydroxy vitaminD36,19-sulfurdioxide adduct was found to be highly promising in terms of binding affinity and ADME features comparable to the known inhibitor (DRO), thus shall be further probed for therapeutic efficacy using experimental validations for effective and natural mode of combating Bcl-2 mediated cancers. Communicated by Ramaswamy H. Sarma Highlights Chemoprofiling of Laetiporus versisporous ethanolic extract by LC-MS analysis. Anti-apoptotic Bcl-2 chosen as drug target based on documentation in similar Genus. Virtual screening of the profiled compounds vs. Bcl-2 inferred (6S)-1alpha, 25-dihydroxyvitamin D3 6,19-sulfur dioxide adduct as a potential novel inhibitor. This molecule also featured significant binding affinity and complex stability during MD comparable to DRO (known inhibitor).
A Comparison of Gradient-Free Optimization Methods in Engineering Applications

This paper compares the solutions achieved by gradient-based and gradient-free solvers in two separate engineering case studies. The first study is a nonlinear least squares problem which regresses parameters for seven simple coal devolatilization models from data. The second study is a campus chiller optimization, which optimizes storage rates and chiller usage meet cooling demand with minimum cost and power. In each case, existing gradient-based solutions are compared against a variety of gradient-free methods. The solutions are compared in terms of objective function value and solution time. For the two case studies investigated, gradient-free algorithms require greatly increase computational time and produce approximately the same solutions as gradient-based solvers.
The positive role of parental attachment and communication in Chinese adolescents' health behavior and mental health during COVID‐19

Abstract Introduction Given that coronavirus disease 2019 (COVID‐19) has largely influenced adolescents' physical and mental health around the globe, it is important to identify protective factors that may promote adolescents' positive adjustment during the pandemic. This study aimed to examine the role of parental attachment and COVID‐19 communication in adolescents' health behavior and mental health during COVID‐19. Methods A total of 442 Chinese parent−adolescent dyads (mean age of adolescents = 13.35 years; 50% girls) completed two‐wave longitudinal surveys over the span of 2 months during the pandemic (Wave 1: July 2020; Wave 2: September 2020). At each wave, adolescents reported on their COVID‐19‐related health behavior, general health behavior, depressive symptoms, and anxiety symptoms. At Wave 1, parent−adolescent attachment security and COVID‐19 communication were also assessed. Results Adolescents' attachment security to parents was associated with their increased COVID‐19‐related and general health behavior as well as decreased depression and anxiety over 2 months during COVID‐19. Moreover, more frequent parent−adolescent COVID‐19 communication was associated with adolescents' increased COVID‐19‐related and general health behavior over time. Notably, attachment security's and COVID‐19 communication's associations with health behavior largely remained the same after taking into account both factors simultaneously. In addition, results from exploratory analyses suggest that more frequent COVID‐19 communication mediates the link between attachment security and increased health behavior. Conclusions These findings highlight the importance of promoting attachment security and COVID‐19 communication between parents and adolescents during the pandemic, which may play a positive role in adolescents' health behavior and mental health.
An effect size for comparing the strength of morphological integration across studies

Understanding how and why phenotypic traits covary is a major interest in evolutionary biology. Biologists have long sought to characterize the extent of morphological integration in organisms, but comparing levels of integration for a set of traits across taxa has been hampered by the lack of a reliable summary measure and testing procedure. Here, we propose a standardized effect size for this purpose, calculated from the relative eigenvalue variance, Vrel$V_{rel}$ . First, we evaluate several eigenvalue dispersion indices under various conditions, and show that only Vrel$V_{rel}$ remains stable across samples size and the number of variables. We then demonstrate that Vrel$V_{rel}$ accurately characterizes input patterns of covariation, so long as redundant dimensions are excluded from the calculations. However, we also show that the variance of the sampling distribution of Vrel$V_{rel}$ depends on input levels of trait covariation, making Vrel$V_{rel}$ unsuitable for direct comparisons. As a solution, we propose transforming Vrel$V_{rel}$ to a standardized effect size (Z‐score) for representing the magnitude of integration for a set of traits. We also propose a two‐sample test for comparing the strength of integration between taxa, and show that this test displays appropriate statistical properties. We provide software for implementing the procedure, and an empirical example illustrates its use.
Joint Milli-Arcsecond Pathfinder Survey Overview

The Joint Milli-Arcsecond Pathfinder Survey (JMAPS) mission is a Department of Navy (DoN) space-based, all-sky astrometric bright star survey. JMAPS is currently funded for flight, with at 2012 launch date. JMAPS will produce an all-sky astrometric, photometric and spectroscopic catalog covering the magnitude range of 1-12, with extended results through 15th magnitude at an accuracy of 1 milliarcsecond (mas) positional accuracy at a mean observing epoch of approximately 2013. Using Hipparcos and Tycho positional data from 1991, proper motions with accuracies of 100 microarcseconds (umas) per year should be achievable for all of the brightest stars, with the result that the catalog will degrade at a much reduced rate over time when compared with the Hipparcos catalog. JMAPS will accomplish this with a relatively modest aperture, very high accuracy astrometric telescope flown in low earth orbit (LEO) aboard a microsat. Mission baseline is for a three-year mission life (2012-2015) in a 900 km sun synchronous terminator orbit.
GAIA: G-quadruplexes in alive creature database

Abstract G-quadruplexes (G4) are 3D structures that are found in both DNA and RNA. Interest in this structure has grown over the past few years due to both its implication in diverse biological mechanisms and its potential use as a therapeutic target, to name two examples. G4s in humans have been widely studied; however, the level of their study in other species remains relatively minimal. That said, progress in this field has resulted in the prediction of G4s structures in various species, ranging from bacteria to eukaryotes. These predictions were analysed in a previous study which revealed that G4s are present in all living kingdoms. To date, eleven different databases have grouped the various G4s depending on either their structures, on the proteins that might bind them, or on their location in the various genomes. However, none of these databases contains information on their location in the transcriptome of many of the implicated species. The GAIA database was designed so as to make this data available online in a user-friendly manner. Through its web interface, users can query GAIA to filter G4s, which, we hope, will help the research in this field. GAIA is available at: https://gaia.cobius. usherbrooke.ca
New technologies : A jobless future or a golden age of job creation ?

The new wave of technological innovation is expected to fundamentally change the future of jobs. The debate on the impact on jobs, however, is controversial. Some expect a jobless future, while others argue that history will repeat itself, and new technologies will eventually create new and better jobs. This research aims at a better understanding of the dynamics of job destruction and job creation. The paper develops a framework to explain the nexus new technology, innovation and job, and the forces driving labour-saving as well as job-creating innovations. Technological change is explained as a nonlinear and complex process which comes in waves and different phases, and market, social and political forces are driving the dynamics of job destruction and job creation. The paper firstly explains the role of market forces in driving automation and fragmentation as two forms of process innovation that destroy jobs in industrial production regimes. Secondly, markets also create jobs by adjusting to increased productivity and jobs losses. However, due to country-specific social capabilities the net impact on jobs differs significantly across countries. Finally, this paper explains the long-term process of moving towards a golden age of job creation. Such a phase of massive job creation can only be achieved by transformative changes in the economy where radically new products and new growth industries emerge in a process of creative destruction. Such changes cannot be generated by markets, they are a social and political choice. The paper argues that unintended consequences of past technological changes have disruptive effects in societies and natural environment which trigger social debates and movements, societal learning processes, and eventually, new social and political demand and new capabilities. It is this social transformation that propels transformative structural changes in the economy and massive job creation. This paper concludes that technological change and the future of jobs is not deterministic, but needs to be shaped. Both, market adjustment and societal learning processes drive endogenously the job-creation dynamics. The challenge for public policies is to foster the dynamics of societal learning and economic transformation. iv Research Department Working Paper No. 13
Design and validation of HIV peptide pools for detection of HIV-specific CD4+ and CD8+ T cells

Reagents to monitor T cell responses to the entire HIV genome, based on well characterized epitopes, are missing. Evaluation of HIV-specific T cell responses is of importance to study natural infection, and therapeutic and vaccine interventions. Experimentally derived CD4+ and CD8+ HIV epitopes from the HIV molecular immunology database were developed into Class I and Class II HIV megapools (MPs). We assessed HIV responses in persons with HIV pre antiretroviral therapy (ART) (n = 17) and post-ART (n = 18) and compared these responses to 15 controls without HIV (matched by sex at birth, age, and ethnicity). Using the Activation Induced Marker (AIM) assay, we quantified HIV-specific total CD4+, memory CD4+, circulating T follicular helper, total CD8+ and memory CD8+ T cells. We also compared the Class I and Class II HIV MPs to commercially available HIV gag peptide pools. Overall, HIV Class II MP detected HIV-specific CD4+ T cells in 21/35 (60%) HIV positive samples and 0/15 HIV negative samples. HIV Class I MP detected an HIV-specific CD8+ T cells in 17/35 (48.6%) HIV positive samples and 0/15 HIV negative samples. Our innovative HIV MPs are reflective of the entire HIV genome, and its performance is comparable to other commercially available peptide pools. Here, we detected HIV-specific CD4+ and CD8+ T cell responses in people on and off ART, but not in people without HIV.
An integrative literature review and critical reflection on nurses' agency

Abstract The idea of agency has long been used in the nursing literature in the study of nurses' roles regarding the patients they take care of, but it has not often been used to study its relationship with nurses themselves and their status in the healthcare system. The purpose of this article is to analyze how the idea of agency is used in nursing research to better understand how we might advance our thinking around nurses' agency to shape nursing and healthcare with an emancipatory intent. Based on the results of a literature review focused on the study of conceptions, treatments, and applications of the concept of agency in nursing, we present a critical discussion to reflect on the need to consistently define the idea of nurses' agency, to guide research concerned with this topic in theoretical frameworks with emancipatory and social change tenets, and to make a call to develop the idea of agency as a central one to rework nurses' relationship with themselves. The idea of agency provides a valuable analytical framework for the study of a wide range of issues around nurses' status in healthcare organizations and in the healthcare system while offering a means for nurses' emancipation.