Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of Omega‐3 Fatty Acids for Prevention or Treatment of Perinatal Depression

Perinatal depression is a complex mental health disorder that can manifest during pregnancy or after childbirth. Women with perinatal depression may not receive proper medical treatment because of concerns over teratogenic effects related to drug therapy. Evidence suggests that low levels of omega‐3 fatty acids are correlated with depressive symptoms during pregnancy and after delivery. Omega‐3 fatty acids may produce antidepressant effects due to their role in serotonin functioning. A literature search identified seven clinical trials of omega‐3 fatty acids for the prevention or treatment of perinatal depression. Depression rating scale scores used in the studies improved, but results were statistically significant in only three trials. Four studies were randomized and placebo controlled, and three were open label. One study evaluating the prevention of postpartum depression in women with a history of depression was discontinued early due to relapse of depressive symptoms. In the trials we evaluated, the most common adverse effects were foul breath and/or unpleasant taste, and gastrointestinal complaints; no serious adverse events were reported. The seven studies were limited by small sample sizes and variable dosing and study durations. In the studies that demonstrated statistical significance, improvement in depression rating scale scores for omega‐3 fatty acids was comparable to placebo. Overall, results have been inconclusive, but further investigation of omega‐3 fatty acids is warranted because they did improve depression scores and appeared to be safe during pregnancy.
The Linear Order Complementarity Problem

The classical complementarity problem in Euclidean space can be viewed alternatively as a variational inequality or as a lattice orthogonality problem. Generalizations of the former have been extensively studied, but infinite-dimensional analogues of the latter have been largely ignored. Moreover, as we show, many well-known results about the classical complementarity problem are more appropriately viewed order-theoretically. This is particularly true of least element solutions, which are central to the present study of order complementarity in vector lattices. We emphasize that the lattice theoretic descriptions we employ are very useful even in the standard finite-dimensional setting.
On the Second Optimality Equation for Semi-Markov Decision Models

For a semi-Markov decision model with average return, the validity of the second optimality equation is shown in the nonmodified form where the actions run through the set of all admissible actions rather than through the set of maximum points conserving actions for the first optimal equation. As a consequence the existence of a strongly optimal stationary policy is shown. The results seem to be known only for finite state finite action models whereas here countable state compact action models with unbounded rewards are considered.
O-0026FOLFOXIRI/BEVACIZUMAB VERSUS FOLFIRI/BEVACIZUMAB AS FIRST-LINE TREATMENT IN UNRESECTABLE METASTATIC COLORECTAL CANCER: RESULTS OF PHASE III TRIBE TRIAL BY GONO GROUP

Background: Doublets plus bevacizumab (bev) are a standard option for the first-line treatment of metastatic colorectal cancer (mCRC). First-line FOLFOXIRI demonstrated superior RR, PFS and OS compared to FOLFIRI. A phase II study of FOLFOXIRI/bev showed promising activity and manageable toxicities. The objective of the TRIBE trial wasto confirm the superiority of FOLFOXIRI vs FOLFIRI when bev is added to chemotherapy (CT). Methods: Eligibility criteria included: measurable and unresectable mCRC, age 18-75 years and no prior CT foradvanced disease. Patients (pts) were randomized to either FOLFIRI/bev (arm A) or FOLFOXIRI/bev (arm B). Both treatments were administered fora maximum of 12 cycles followed by 5FU/bev until progression. Primaryendpoint was PFS. Results: Between July 2008 and May 2011 508 pts were randomized. Pts characteristics were (arm A/arm B): median age 60/61, ECOG PS 1-2 11%/10%, synchronous metastases 81%/79%, multiple sites of disease 74%/70%, liver-only disease 18%/23% and prior adjuvant (adj) 12%/12%. At a
AugKey: Increasing Foveal Throughput in Eye Typing with Augmented Keys

Eye-typing is an important tool for people with physical disabilities and, for some, it is their main form of communication. By observing expert typists using physical keyboards, we notice that visual throughput is considerably reduced in current eye-typing solutions. We propose AugKey to improve throughput by augmenting keys with a prefix, to allow continuous text inspection, and suffixes to speed up typing with word prediction. AugKey limits the visual information to the foveal region to minimize eye movements (i.e., reduce eye work). We have applied AugKey to a dwell-time keyboard and compared its performance with two conditions with no augmented feedback: a keyboard with and one without word prediction. Results show that AugKey can be about 28% faster than no word prediction and 20% faster than traditional word prediction, with a smaller workload index.
Quadratic Convergence in a Primal-Dual Method

We show that the Mizuno-Todd-Ye O (√ nL ) iteration predictor-corrector primal-dual interior-point algorithm for linear programming is quadratically convergent. Our proof does not assume that the problems be nondegenerate. We do not assume that the iterate generated by the algorithm be convergent, an assumption common to all previous asymptotic convergence analysis.
Stable Matchings, Optimal Assignments, and Linear Programming

Vande Vate 1989 described the polytope whose extreme points are the stable core matchings in the Marriage Problem. Rothblum 1989 simplified and extended this result. This paper explores a corresponding linear program, its dual and consequences of the fact that the dual solutions have an unusually direct relation to the primal solutions. This close relationship allows us to provide simple proofs both of Vande Vate and Rothblum's results and of other important results about the core of marriage markets. These proofs help explain the structure shared by the marriage problem without sidepayments and the assignment game with sidepayments. The paper further explores "fractional" matchings, which may be interpreted as lotteries over possible matches or as time-sharing arrangements. We show that those fractional matchings in the Stable Marriage Polytope form a lattice with respect to a partial ordering that involves stochastic dominance. Thus, all expected utility functions corresponding to the same ordinal preferences will agree on the relevant comparisons. Finally, we provide linear programming proofs of slightly stronger versions of known incentive compatibility results.
Bringing Learning to Light: Innovative Instructional Strategies for Teaching Infection Control to Nursing Students

Abstract Infection control practices are at the forefront of education and compliance monitoring. A university-funded grant allowed faculty and instructional designers to create an experience that increased student awareness, application, and appreciation of infection-control concepts. Computer-based instruction modules are used to provide content, and students participate in a simulation that allows them to apply their newly learned skills in a realistic, immersive environment with a biosphere used to visually depict infectious spread. Student feedback suggests the usefulness of this methodology as a teaching strategy that reinforces evidence-based practice, critical thinking, and clinical judgments.
Selective Exploration of Commercial Documents in Web Search

Implicit user feedback is known to be a strong signal of user preferences in web search. Hence, solving the exploration-exploitation dilemma [5] became an important direction of improvement of ranking algorithms in the last years. In this poster, in the case of commercial queries, we consider a new negative effect of exploration on the user utility -- distracting and confusing users by shifting well-known documents from their common positions -- and propose an approach to take it into account within Multi-Armed Bandit algorithms, usually applied to solve the dilemma.
PHYSICIAN ACCEPTANCE OF COMPUTERIZED PHYSICIAN ORDER ENTRY IN OUTPATIENT SETTINGS: A QUANTITATIVE ANALYSIS OF FAMILY MEDICINE WITHIN MARICOPA COUNTY, ARIZONA

The relationship between the acceptance of Computerized Physician Order Entry (CPOE) by MD and DO family medicine physicians in Maricopa County, Arizona and physician age, practice size, hours per week of personal computer use, and years of experience working as physician was analyzed. Written invitations were mailed to 1,118 MD and DO family medicine physicians in Maricopa County. Fifty-three (4.74%) physicians participated in the survey. At the . 05 level, the acceptance of CPOE as measured by the mean score of the 23 scales of the extended technology acceptance model (TAM2) was found to have no significant relationship between age, practice size, hours per week of personal computer use, and years of experience as a physician. At the . 10 level, only the relationship between physician acceptance of CPOE and years of experience was found to be significant. With an increased sample size, the relationship between technology acceptance and factors of age, practice size, personal computer usage, and years of medical practice experience could possibly show to have a significant relationship.
DREAM in Action: A Distributed and Adaptive RDF System on the Cloud

RDF and SPARQL query language are gaining wide popularity and acceptance. This demonstration paper presents DREAM, a hybrid RDF system, which combines the advantages and averts the disadvantages of the centralized and distributed RDF schemes. In particular, DREAM avoids partitioning RDF datasets and reversely partitions SPARQL queries. By not partitioning datasets, DREAM offers a general paradigm for different types of pattern matching queries and entirely precludes intermediate data shuffling (only auxiliary data are shuffled). By partitioning only queries, DREAM suggests an adaptive scheme, which runs queries on different numbers of machines depending on their complexities. DREAM achieves these goals and significantly outperforms related systems via employing a novel graph-based, rule-oriented query planner and a new cost model. This paper proposes demonstrating DREAM live over the cloud using a friendly graphical user interface (GUI). The GUI allows participants to execute and visualize pre-defined and user-defined (which can be written by participants on-the-fly) SPARQL queries over various real-world and synthetic RDF datasets. Furthermore, participants can empirically compare and contrast DREAM against three state-of-the-art RDF systems.
Repeated Games and Partial Differential Equations

Let vnp denote the value of the n-times repeated zero-sum game with incomplete information on one side and full monitoring and let up be the value of the average game Gp. The error term enp = vnp-cavup is then converging to zero at least as rapidly as 1/√n. In this paper, we analyze the convergence of ψnp = √nenp in the games with square payoff matrices such that the optimal strategy of the informed player in the average game Gp is unique, is completely mixed and does not depend on p. Our main result is that the existence of a solution ψ* to a partial differential equation with appropriate boundary conditions and regularity properties implies the uniform convergence of ψn to the Fenchel conjugate of ψ*. In particular cases, the P.D. E. problem is linear and its solution ψ* is then related to the multidimensional normal distribution.
Nicht-viraler Gentransfer führt zu therapeutischen Faktor-IX-Spiegeln im Hämophilie-B-Mausmodell

Zusammenfassung In ersten klinischen Gentherapiestudien mit viralen Vektoren sind Bedenken hinsichtlich des Risikos der Entstehung von Malignomen sowie bezüglich unerwarteter Immunantworten gegen virale Proteine aufgekommen. Im Gegensatz dazu standen nicht virale Therapien bisher eher im Abseits. In unserer Studie untersuchen wir daher einen nicht-viralen Ansatz zur Behandlung der Hämophilie B. Methodik: Zuerst wurde ein Expressionsplasmid für eine starke leberspezifische Faktor-IX(FIX)-Expression konstruiert. Um den Vektor zu testen, wurden Gruppen von FIX-Knockout-Mäusen zwei Vektordosierungen mittels hydrodynamischer Injektionstechnik appliziert. Ergebnis: Bereits eine einmalige Behandlung führte zu FIX-Expression oberhalb 100% normaler Plasmaspiegel. Das FIX-Protein war voll funktionsfähig, inhibitorische Antikörper gegen FIX wurden nicht beobachtet, Expressionsspiegel waren abhängig von der Vektordosis. Schlussfolgerung: Die hier vorgestellten FIX-Expressionsspiegel im Mausmodell geben Hoffnung auf die Weiterentwicklung nicht viraler Gentherapieansätzen zur Behandlung der Hämophilie B auch am Menschen.
Screening and prediction of paroxysmal atrial fibrillation by analysis of heart rate variability parameters

This study has been performed within the scope of the CinC-2001 challenge on the detection and prediction of paroxysmal atrial fibrillation (PAF) from 200 paired two-channel ECGs of 30 minutes duration. Different features of heart rate variability (HRV) describing the magnitude as well as the regularity of heart rate fluctuations and the number of supraventricular premature beats (SVPCs) and ventricular premature beats (VPCs) were investigated for their suitability with respect to the classification task using ROC analysis, classification by ranks and linear polynomial classifiers with jackknife validation. Moreover, the time courses of mean parameter values were calculated to identify possible trends. Although promising results of up to more than 80% accuracy in screening and 92% in prediction were achieved on training data, these were not reproducible on an independent test set.
PULSE WAVE ANALYSIS IN TYPE 1 DIABETES: RELATIONSHIP WITH HISTORICAL MEASURES AND PREVALENT DISEASE

Type 1 diabetes (T1D) is associated with numerous complications. These include renal and cardiovascular disease which are the leading causes of morbidity and mortality in T1D. Renal complications also increase the risk for cardiovascular disease. Early detection and treatment of their risk factors may help to prevent or at least delay these complications. This dissertation examines potential risk factors for altered measures of pulse wave analysis (PWA), which have been linked to cardiovascular events and mortality in other populations. It also examines how PWA measures relate to prevalent cardiovascular and renal complications in T1D.Prospective analyses of potential risk factors for increased arterial stiffness indices, augmentation index (AIx) and augmentation pressure (AP), and decreased estimated myocardial perfusion, i.e. subendocardial viability ratio (SEVR), showed autonomic neuropathy, smoking history, low HDL cholesterol and poorer glycemic control, to be associated with altered PWA measures 18 years later.Next, cross-sectional analyses between PWA measures and prevalent CVD showed AP and SEVR to be significantly related to coronary artery disease and coronary artery calcification, respectively, although age was the major predictor of both. AP was also higher, although not significantly, and SEVR significantly lower in those with peripheral vascular disease.Finally, SEVR, but not AIx nor AP, was significantly associated with the presence of microalbuminuria (MA), and preferentially entered multivariate models over brachial blood pressure measures. SEVR was also related to degree of albuminuria in those within the normo- and MA range, and was significantly associated, multivariately, with low renal function.This dissertation thus yields significant Public Health findings by identifying factors (AN, smoking, glycemic control, lipid levels) that may delay increased arterial stiffness (AIx and AP) and decreased myocardial perfusion (SEVR). As it additionally shows that these same PWA measures are altered in the presence of CVD and renal damage in T1D a potential role for PWA measures, especially SEVR, in risk stratification and early intervention for T1D complications is apparent.
Psychosocial Correlates of Health Care Utilization for Children and Adolescents With Type 1 Diabetes Mellitus

Our objective was to examine the relation of self-reported depressive symptomatology to health care utilization (HCU) in families with a child with Type 1 diabetes mellitus (DM1). Data were obtained from a community sample (N = 88) being followed in 2 private outpatient diabetes clinics. Children and adolescents completed measures of depressive symptomatology. Mothers provided demographic information and completed measures of HCU and depressive symptomatology. Physicians provided measures of glycosylated hemoglobin (HbA1c) and illness severity. Hierarchical regression analyses indicated that higher levels of child depressive symptomatology were associated with increased HCU for children with DM1 above and beyond demographic and illness variables. However, no significant relationship was found between either adolescent or maternal depressive symptomatology and HCU. These findings suggest self-reported depressive symptomatology in children with DM1 is a salient correlate of HCU even after statistically controlling for the influence of demographics and illness parameters. The possibility that children with DM1 with symptoms of depression may have higher utilization of health services supports the need to target psychosocial variables for intervention.
A Note on the Finite Time Behavior of Simulated Annealing

Simulated Annealing has proven to be a very successful heuristic for various combinatorial optimization problems. It is a randomized algorithm that attempts to find the global optimum with high probability by local exchanges. In this paper we give a new proof of the convergence of Simulated Annealing by applying results about rapidly mixing Markov chains. With this proof technique it is possible to obtain better bounds for the finite time behavior of Simulated Annealing than previously known.
A New Yardstick for Rating Dental Arch Relationship in Patients with Complete Bilateral Cleft Lip and Palate

Objective To develop yardsticks for assessment of dental arch relationship in young individuals with repaired complete bilateral cleft lip and palate appropriate to different stages of dental development. Participants Eleven cleft team orthodontists from five countries worked on the projects for 4 days. A total of 776 sets of standardized plaster models from 411 patients with operated complete bilateral cleft lip and palate were available for the exercise. Statistics The interexaminer reliability was calculated using weighted kappa statistics. Results The interrater weighted kappa scores were between . 74 and . 92, which is in the “good” to “very good” categories. Conclusions Three bilateral cleft lip and palate yardsticks for different developmental stages of the dentition were made: one for the deciduous dentition (6-year-olds’ yardstick), one for early mixed dentition (9-year-olds’ yardstick), and one for early permanent dentition (12-year-olds’ yardstick).
On Team Guessing with Independent Information

Team theory is the study of situations in which a set of cooperating agents, called a team, each with access to different data or information, attempt to optimize a common criterion, under rules which restrict communication between agents. Team theory is of interest in theoretical studies in economics, communication and control. A very simple example of a team situation is the following. Each of the team's n agents attempts to ascertain whether or not a certain random event E of probability ½ has occurred. Agent i must base his decision solely on the observation of random variable Ui and the team's goal is to minimize pI = n-1 Σpi, where pi is the probability that agent i makes an error. The main result of this paper is to show that when the variables U1,. , Un are independent, this alone places a positive lower bound on pI, no matter what the joint distribution of E and the data {Ui} may be. For each n the exact lower bound is determined: it is $\frac{1}{2} \sqrt{2}-1$ for n = 2, ¼ for n = 3 and as n goes to infinity it is asymptotic to $$\frac{1}{2} \left1-\sqrt{\frac{2}{\pi n}}\right$$
A Group Learning Programme for Old People with Hip Fracture: A Randomized Study

The aim of this study was to examine whether a group learning programme would influence the participants' perceived activity performance and ability to participate in social life after a hip fracture. The study comprised 35 people aged 54-90 years with hip fracture who had completed ordinary care and rehabilitation after their hip fractures. They were randomized to an intervention group (n=21) or to a control group (n=14). The intervention group participated in the group learning programme, while the control group received no intervention. Directly after the intervention and at 12 months after the intervention, no significant change was seen in either group, regarding the ability to perform ADL activities measured by the Barthel ADL index, or the performance of activities that were identified as important to the individual. However, in the intervention group, the number of ADL items perceived to be performed with difficulties decreased, and the perceived ability to participate in social life increased. These changes were not found in the control group. When analysed between groups, however, the only significant difference was the ability to participate in social life after the intervention. Further research is needed to investigate whether an intensive or prolonged period of rehabilitation, at the hospital or in the patient's home, would increase the ability to resume meaningful participation in social life.
Different perspectives on information systems: problems and solutions

The paper puts information systems (IS) research dealing with IS problems into perspective. IS problems are surveyed and classified. Using the IS research framework suggested by Ives, Hamilton, and Davis, research into IS problems is classified into several perspectives whose relevance in coping with the problems is discussed. Research perspectives focusing on IS operations environment, IS development process, IS development organization, IS development methods, and IS theories are distinguished. The paper concludes with suggestions for future research and how to deal with IS problems in practice.
The Roles of Rap1 in Cancer Metastasis and Pancreatic Islet Beta Cell Function

The Roles of Rap1 in Cancer Metastasis and Pancreatic Islet Beta Cell Function by Candice L. Bailey Department of Pharmacology & Cancer Biology Duke University Date:_______________________ Approved: ___________________________ Patrick J. Casey, Ph.D., Supervisor ___________________________ Ann Marie Pendergast, Ph.D. ___________________________ Gerard C. Blobe, M.D., Ph.D. ___________________________ Leslie V. Parise, Ph.D. An abstract of a dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Molecular Cancer Biology in the Graduate School of Duke University 2009
O Mini-Exame do Estado Mental em uma população geral: impacto da escolaridade

To assess the influence of age and education on cognitive performance in our population, 530 adults were interviewed using the MMSE (Mini-Mental Status Examination). Education level, classified as illiterate, elementary and middle ( 8 years), was a significant predictor of performance (p or = 65 years). The reference cut-off values were taken from the fifth percent lowest score for each group: illiterate, 13; elementary and middle, 18; and high, 26. When compared to 94 pacients with cognitive impairment, our cut-off values achieved high sensitivity (82.4% for illiterates; 75.6% for elementary and middle; 80% for high) and specificity (97.5% for illiterate; 96.6% for elementary and middle; 95.6% for high educational level). Education-specific reference values for the MMSE are necessary in interpreting individual test results in populations of low educational level, in order to reduce the false positive results.