Miracle-dz/UniFAR-FTUs huggingface dataset:
Personalized Medicine in the Age of Pharmacoproteomics: A Close up on India and Need for Social Science Engagement for Responsible Innovation in Post-Proteomic Biology.

“Because DNA sequencing technology is inherently simpler and more scalable than protein analytical technology, and because the finiteness of genomes invited a spirit of rapid conquest, the notion of genome sequencing has displaced that of protein databases in the minds of most molecular biologists for the last decade…As proteomics now takes center stage in molecular biology, it is appropriate to take stock of progress to date and consider the major strategic objectives that can be achieved during the next stages of its evolution”.
Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1).

In response to various external stimuli, MAP kinases are activated by phosphorylation on tyrosine and threonine by MAP kinase kinase (MAPKK), a dual specificity kinase. This kinase is in turn activated via Raf‐1 and MAPKK kinase (MAPKKK). To determine regulatory phosphorylation sites of MAPKK, we isolated a Chinese hamster cDNA, that we epitope‐tagged and expressed in fibroblasts. This hamster MAPKK (MEK1 isoform) can reactivate recombinant p44mapk when immunoprecipitated from growth factor‐stimulated cells or when incubated with an active form of MAPKKK. Mutations at either of two residues that are conserved among kinases, D208N or S222A, abolished MAPKK activity. However, only S222A/MAPKK showed a reduction in phosphorylation in response to active MAPKKK and exerted a dominant negative effect on the serum‐stimulated endogenous MAPKK. Finally, replacing Ser222 with Asp, a negatively charged residue, restored MAPKK activity independently of the upstream kinase. These results strongly suggest that Ser222 represents one key MAPKKK‐dependent phosphorylation site switching on and off the activity of MAPKK, an event crucial for growth control.
Nonlinear Optical Molecular Switches for Alkali Ion Identification

This work demonstrates by means of DFT and ab initio calculations that recognition of alkali cations can be achieved by probing the variations of the second-order nonlinear optical properties along the commutation process in spiropyran/merocyanine systems. Due to the ability of the merocyanine isomer to complex metal cations, the switching between the two forms is accompanied by large contrasts in the quadratic hyperpolarizability that strongly depend on the size of the cation in presence. Exploiting the nonlinear optical responses of molecular switches should therefore provide powerful analytical tools for detecting and identifying metal cations in solution.
Microscopic colitis is not associated with cholecystectomy or appendectomy

Background: Microscopic colitis is a common cause of chronic watery diarrhea of unknown origin. Some patients develop diarrhea after cholecystectomy, and some patients with microscopic colitis have evidence of bile acid malabsorption. However, the association between cholecystectomy and microscopic colitis has not been studied. A protective effect of appendectomy on the development of ulcerative colitis also has been reported, but its relationship with microscopic colitis has not been studied. The aim of this study was to assess cholecystectomy and appendectomy as potential risk factors for the development of microscopic colitis in a nested case‐control study. Materials and Methods: Using the Rochester Epidemiology Project, we identified all Olmsted County (Minnesota) residents with an initial diagnosis of microscopic colitis between January 1, 1985, and December 31, 2001. Rates of antecedent cholecystectomy or appendectomy in patients with microscopic colitis were compared with age‐, gender‐, and calendar year‐matched community controls through conditional logistic regression. Results: Microscopic colitis was identified in 130 cases. Cholecystectomy preceded the diagnosis of microscopic colitis in 12 cases (9%) compared with 17 (13%) in the control group (odds ratio [OR] 0.7; 95% CI 0.3–1.5). Appendectomy preceded the diagnosis of microscopic colitis in 39 subjects (30%) compared with 28 (22%) in the control group (OR 1.6; 95% CI 0.9–2.7). Similar results were obtained when the analysis was restricted to microscopic colitis subtype (lymphocytic colitis or collagenous colitis). Conclusions: In this population‐based nested case‐control study, no significant association was seen between cholecystectomy or appendectomy and the development of microscopic colitis or its subtypes.
Cognitive Impairment and Depression in Community-Dwelling Older Korean Women

Cognitive impairment and depression were investigated in older Korean women. 143 Korean women (M age = 75.8) attending four senior service community centers in Seoul participated. 27% scored as possibly demented and 15% as demented on the Korean version of the Mini-Mental State Examination. 57% scored as depressed on the Korean Geriatric Depression Scale. Younger elderly women (ages 65–74 years) displayed less cognitive impairment than older women. Older elderly Korean women (> 75 yr.) who lived with their spouses scored as more cognitively stable than those who lived without spouses. Those with inadequate income scored higher on Depression, which was inversely correlated with cognitive function in the entire sample. Dementia and depression were found to be more frequent in this elderly sample than previously reported by the Korean government.
Reconceptualizing the meaning and domain of marketing knowledge

The knowledge‐based view of the firm suggests that knowledge is the firm’s key resource for creating and sustaining economic rent. This perspective raises an important question for marketers: What is marketing knowledge? We argue first that marketing knowledge resides in three key marketing processes: product development management, customer relationship management, and supply chain management. Second, we argue that marketing knowledge is the extent of understanding of these three marketing processes, an extent which can be measured by evaluating awareness of factors, control of factors, and application of knowledge in new markets. We empirically test this conceptualization of marketing knowledge and, as a predictive validation, examine its relationship with marketing innovation.
Central arterial pulse waveform acquisition with a portable pen-like optical fiber sensor

ObjectivePulse waveform features related to cardiovascular pathologies and arterial stiffness have been extensively studied, and optical fiber sensors have been studied with an aim to simplify the pulse waveform acquisition in the carotid artery. In this paper, a novel optical fiber sensor to record pulse waveform in the carotid artery has been proposed. MethodsThe pulse waveform optical fiber sensor design, based on fiber Bragg gratings, is presented. The probe was characterized, and its response to controlled waveforms was studied. Finally, tests were performed on human subjects. ResultsThe developed sensor has a displacement sensitivity of 21.2 pm/&mgr;m, with ability to detect the carotid pulse wave in the neck surface, with a resolution of 1.3 mmHg. ConclusionThis study revealed a new technological approach for acquisition of the central pulse waveform.
Automatic program instrumentation in generation of test data using genetic algorithm for multiple paths coverage

Software testing is an important step during software development. By doing automation of software testing we can increase the robustness of software and decrease the cost of development. The automation of test data generation is done using genetic algorithm. GA analyses the fitness based on the path coverage. This paper presents a novel method for test data generation with multiple paths coverage for instrumented programs. The dynamic instrumentation method is used for analyzing the source code which has been incorporated in java using AspectJ. This reduces the effort of man power required for debugging programs through inserting probes. The experimental results show that the Path Reuse Method (PRM) given in this paper reduces the execution time and no of generations. The PRM automates the test input generation for testing aspectual behavior of object-oriented programs.
The effects of anxiety and exercise-induced fatigue on shooting accuracy and cognitive performance in infantry soldiers

Operational performance in military settings involves physical and mental skills that are generally investigated separately in lab settings, leading to reduced ecological validity. Therefore, we investigated the effects of anxiety and exercise-induced fatigue, separately and in combination, on cognitive and shooting performance of 22 soldiers in a real-world setting. Findings indicated that soldiers' shooting accuracy and decision-making and mathematical skills decreased significantly under anxiety. Whether exercise-induced fatigue was beneficial or detrimental to task performance depended on the task at hand. The increased arousal levels through exercise prevented shooting accuracy from deteriorating in the decision task. In contrast, cognitive performance suffered from the increased arousal: participants more often failed to shoot when being fired at by an opponent and also math performance seemed to decrease. We conclude that anxiety can deteriorate soldier performance and that exercise-induced fatigue may improve or deteriorate performance in combination with anxiety depending on the nature of the task. Practitioner Summary: Soldiers encounter anxiety and exercise-induced fatigue. We investigated to what degree these factors influence soldiers' shooting and cognitive performance. Experimental manipulation of anxiety and exercise during a representative field course indicated decreased performance under anxiety. Exercise prevented shooting accuracy from deteriorating under anxiety, although cognitive performance was negatively affected after exercise.
THE CORRECTION OF SURFACE LAYER WIND SPEEDS FOR ATMOSPHERIC STRATIFICATION AND HEIGHT

The comparison of SAR-derived wind speeds from scatterometer-based transfer functions and in situ or model wind speeds requires that both data sets represent the presence of equivalent atmospheric stratification and measurement height. We discuss the atmospheric surface layer dynamics underlying corrections to equivalent atmospheric stratification and measurement height. In addition, we review available methods for carrying out the corrections focusing on bulk flux algorithms available in the literature.
Stretching Dielectric Elastomer Performance

Devices using materials that deform in response to electricity are based on a phenomenon that was observed more than two centuries ago. The idea that a solid material can deform when stimulated by electricity originated in the late-18th century with observations of ruptures in overcharged Leyden jars, the first electrical capacitors. In 1776, Italian scientist Alessandro Volta mentioned in a letter that Italian experimenter Felice Fontana had noted volume changes in the Leyden jar upon electrification (1), an observation that launched a new field of investigation—“deformable” materials affected by electricity. More than two centuries later, the concept of “electrically stretchable materials” is at the forefront of devising bioinspired robots, tactile and haptic interfaces, and adaptive optical systems (2, 3).
BINARY FORMATION MECHANISMS: CONSTRAINTS FROM THE COMPANION MASS RATIO DISTRIBUTION

We present a statistical comparison of the mass ratio distribution of companions, as observed in different multiplicity surveys, to the most recent estimate of the single-object mass function. The main goal of our analysis is to test whether or not the observed companion mass ratio distribution (CMRD) as a function of primary star mass and star formation environment is consistent with having been drawn from the field star initial mass function (IMF). We consider samples of companions for M dwarfs, solar-type stars, and intermediate-mass stars, both in the field as well as clusters or associations, and compare them with populations of binaries generated by random pairing from the assumed IMF for a fixed primary mass. With regard to the field we can reject the hypothesis that the CMRD was drawn from the IMF for different primary mass ranges: the observed CMRDs show a larger number of equal-mass systems than predicted by the IMF. This is in agreement with fragmentation theories of binary formation. For the open clusters α Persei and the Pleiades we also reject the IMF random-pairing hypothesis. Concerning young star-forming regions, currently we can rule out a connection between the CMRD and the field IMF in Taurus but not in Chamaeleon I. Larger and different samples are needed to better constrain the result as a function of the environment. We also consider other companion mass functions and we compare them with observations. Moreover the CMRD both in the field and clusters or associations appears to be independent of separation in the range covered by the observations. Combining therefore the CMRDs of M (1–2400 AU) and G (28–1590 AU) primaries in the field and intermediate-mass primary binaries in Sco OB2 (29–1612 AU) for mass ratios, q = M2/M1, from 0.2 to 1, we find that the best chi-square fit follows a power law dN/dq∝qβ, with β = −0.50 ± 0.29, consistent with previous results. Finally, we note that the Kolmogorov–Smirnov test gives a ∼1% probability of the observed CMRD in the Pleiades and Taurus being consistent with that observed for solar-type primaries in the field over comparable primary mass range. This highlights the value of using CMRDs to understand which star formation events contribute most to the field.
The equilibrium function of the otolith organs of the thornback ray (Raja clavata)

During the oscillographic study of the mode of function of the semicircular canals of the ray (Lowenstein & Sand, 1940a, b), it became clear that the accessibility of the elasmobranch labyrinth and the satisfactory survival of preparations of the labyrinth in the isolated otic capsule opened up the possibility of an extension of the work to the otolith organs in the utriculus, sacculus and lagena. This has now been carried out in experiments described in the present paper. METHODS
A novel PTCH1 gene mutation in a pediatric patient associated multiple keratocystic odontogenic tumors of the jaws and Gorlin–Goltz syndrome

Gorlin–Goltz syndrome (GGS) is an uncommon autosomal dominant inherited disorder which comprises the triad of basal cell carcinomas (BCCs), odontogenic keratocysts, and musculoskeletal malformations. Besides this triad, neurological, ophthalmic, endocrine, and genital manifestations are known to be variable. It is occasionally associated with aggressive BCC and internal malignancies. This report documents a case of GGS with a novel mutation in the PTCH1 gene in an 11-year-old child. The clinical, radiographic, histopathologic and molecular findings of this condition, and treatment are described, and a review of GGS was carried out.
Motivational dynamics underlying eating regulation in young and adult female dieters: relationships with healthy eating behaviours and disordered eating symptoms

Objective: To investigate whether type of goals and motives underlying females’ eating regulation are associated differentially with daily eating behaviours, dependent upon weight and age category. Design: 99 late adolescent female dieters (Mage = 18.94) and 98 adult female dieters (Mage = 45.06), 23.6% of which were overweight, completed a questionnaire and a 7-day diary assessment. Descriptive analysis and path analysis were performed to investigate the research questions. Main outcome measures: Healthy eating behaviours (HEHS), drive for thinness and binge eating symptoms (EDI). Results: Appearance-focused and controlled eating regulation were positively related to disordered eating symptoms throughout the week. In contrast, autonomous and health-focused eating regulation were associated positively with healthy eating behaviours and were either related negatively or unrelated to disordered eating symptoms. Mean level differences in motivation and eating behaviours emerged according to age and weight status. However, the examined structural model was similar for late adolescent and adult dieters and only few differences emerged between normal-weight and overweight dieters. Conclusion: Dieters’ type of motivation helps to explain when eating regulation relates to healthy and disordered eating symptoms.
The Perceptions of Teachers towards the Effectiveness of Class-based Mentors in the Mentoring of Student Teachers on Teaching Practice

Abstract This research sought to determine the effectiveness of mentoring of student teachers on teaching practice by class-based mentors as perceived by teaching diploma holder in Binga District Primary Schools. In this research, a random sample of 30 teachers, conveniently selected from six primary schools was used as research subjects. The descriptive survey was the research method suitable for the research and a self–administered questionnaire was used as the research instrument to gather relevant data. The rate of return of the questionnaire was 100%. Data collected was presented through tables and graphs. The research study showed that while classbased mentors played a significant contribution in the professional development of student teachers on teaching practice, they lacked the necessary mentoring knowledge and skills to perform their roles with expertise particularly in the areas of joint approaches, building positive mentor-mentee relationships and assessment. It was also revealed that class-based mentors were not committed to their duties. The research recommends that class-based mentors be given the necessary orientation and training in mentoring knowledge and skills. It is also necessary to attach student teachers to teachers with less school duties so that there is adequate time for joint approaches.
Trichloroethylene Dose Response Assessment : Additional Issues Relevant for a Scientifically Credible Approach

Several issues associated with the hazard identification and dose response assessment of trichloroethylene are discussed. These issues include the identification of TCE’s critical effect and overall cancer weight of evidence, the use of the recently harmonized TCE PBPK model for improving extrapolations from experimental animal to humans, an understanding of uncertainty in dose response assessment, and use of differing cancer slope factors in risk management decisions. Based on this discussion and analyses, we suggest research that might both ameliorate several of the uncertainties in the assessment of TCE’s risk and provide a foundation for an international effort at harmonization of disparate dose response assessment values.
Mice carrying a R142C Notch 3 knock–in mutation do not develop a CADASIL‐like phenotype

CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy, MIM 125310) is a genetic vascular dementia disease that is linked to missense mutations, small in‐frame deletions, and splice site mutations in the human Notch 3 gene. Here we describe the generation of a mouse knockin model for one of the most prevalent CADASIL mutations, an arginine to cysteine transition at position 141, R141C, which corresponds to mutation R142C in mouse NOTCH 3. CADASILR142C mice show no apparent CADASIL‐like phenotype after histological and MRI analysis. The NOTCH 3 R142C receptor is processed normally and does not appear to accumulate the ectodomain, which has been observed in CADASIL patients. We discuss possible reasons for the different outcomes of the same germline CADASIL mutation in mice and humans. genesis 41:13–22, 2005. © 2005 Wiley‐Liss, Inc.
Sensory Evaluation and Microbial Analysis of Apple and Pear Mixed Fruit Jam Prepared from Varieties Grown in Azad Jammu and Kashmir

3 Abstract: A comparative study was carried out on mixed fruit jam of (Apple + Pear) pulp incorporated within the ratio of 50:50 (T1), 60:40 (T2) 40:60 (T3) 100% apple (T4) 100 % pear (T5). All jam samples were stored in sterilized glass jars at ambient temperature and evaluated for total fungal count (TFC) and sensorically observed for colour, taste texture and overall acceptability for interval of 15 days during 3 months storage period. All the samples were significantly different at (p<0.05) during storage. The results regarding to total fungal count showed a gradual increase in TFC, where as the maximum mean value was recorded A comparative study was carried out on mixed fruit jam of (apple + pear) for (T ) and minimum for (T ). Result showed a decrease in color 54 score Maximum mean score for color was obtained by T (7.529) and minimum by (T ). A decrease in taste score 45 was recorded, where as maximum means score was obtained by T (6.729) and minimum by T (6.257). Texture 45 of the samples also decreased during storage maximum means score was obtained by T (7.929) and minimum 4 by T (7.086). Results regarding to overall acceptability showed a gradual decrease. Maximum mean score was 5 obtained by T (7.929) and minimum by T (7.086). It was concluded that the (mixed apple and pear) jam was 45 successfully prepared and remain acceptable for 90 days.
Program concept recognition

Program understanding can be greatly assisted by automating the recognition of abstract concepts present in the program code. The authors describe an approach to automated concept recognition and its implementation. In the approach, a concept model and a library of concept recognition rules are used to describe what the concepts are and how to recognize them from lower-level concepts. Programming language knowledge as well as domain knowledge are both used to aid the recognition of abstract concepts. <<ETX>>
Transformative Learning and Graduate Nurses’ Understanding of the Complexities of Diabetes Self-Management

Clinical nurses are increasingly responsible for facilitating and providing diabetes education in the acute care setting. However, research suggests that the lack of awareness about the psychosocial factors that influence diabetes self-management impairs the nurse’s ability to effectively and comprehensively support the patient’s self-management efforts. This mixed-methods design of the research study describes how transformative learning, in conjunction with critical reflection, enhanced graduate nurses’ understanding of the psychosocial aspects of diabetes self-management and improved their ability to provide patient-centered care.
Optimal Effective Capacity for Cooperative Relay Networks With QoS Guarantees

In this paper, we propose a resource allocation scheme to maximize the system throughput subject to the queue overflow quality-of-service (QoS) requirement for wireless cooperative networks. Specifically, the considered network consists of one source-destination pair and N relays that can detect and forward the source's message. By integrating the concept of effective capacity with cooperative relay networks, the proposed scheme allocates each relay a time slot of optimal length during the cooperation phase, based on the channel statistics. Our analysis shows that selecting the relay with the best channel condition for cooperation is optimal when no QoS requirement is considered, while more relays should participate in cooperation when the level of QoS requirement becomes more stringent.