Miracle-dz/UniFAR-FTUs huggingface dataset:
The Structural Determinants for α1-Adrenergic/Serotonin Receptors Activity among Phenylpiperazine-Hydantoin Derivatives

Several studies confirmed the reciprocal interactions between adrenergic and serotoninergic systems and the influence of these phenomena on the pathogenesis of anxiety. Hence, searching for chemical agents with a multifunctional pharmacodynamic profile may bring highly effective therapy for CNS disorders. This study presents a deep structural insight into the hydantoin-arylpiperazine group and their serotonin/α-adrenergic activity. The newly synthesized compounds were tested in the radioligand binding assay and the intrinsic activity was evaluated for the selected derivatives. The computer-aided SAR analysis enabled us to answer questions about the influence of particular structural fragments on selective vs. multifunctional activity. As a result of the performed investigations, there were two leading structures: (a) compound 12 with multifunctional adrenergic-serotonin activity, which is a promising candidate to be an effective anxiolytic agent; (b) compound 14 with high α1A/α1D affinity and selectivity towards α1B, which is recommended due to the elimination of probable cardiotoxic effect. The structural conclusions of this work provide significant support for future lead optimization in order to achieve the desired pharmacodynamic profile in searching for new CNS-modulating agents.
WMA: A Multi-Scale Self-Attention Feature Extraction Network Based on Weight Sharing for VQA

Visual Question Answering (VQA) has attracted extensive research focus and has become a hot topic in deep learning recently. The development of computer vision and natural language processing technology has contributed to the advancement of this research area. Key solutions to improve the performance of VQA system exist in feature extraction, multimodal fusion, and answer prediction modules. There exists an unsolved issue in the popular VQA image feature extraction module that extracts the fine-grained features from objects of different scale difficultly. In this paper, a novel feature extraction network that combines multi-scale convolution and self-attention branches to solve the above problem is designed. Our approach achieves the state-of-the-art performance of a single model on Pascal VOC 2012, VQA 1.0, and VQA 2.0 datasets.
Shear Characteristics of Large Anchorage System

Large anchorage system with anchor bolt exceeding 50mm of bolt diameter or effective embedment depth deeper than 635mm is usually used in nuclear concrete structure, but shear design criteria for large anchorage system is not clearly addressed by ACI 349-06 Appendix B (ACI 349, 2006). Therefore, to find out the shear characteristics of large anchorage system, 24 prototype specimens were manufactured and tested by ASTM E 488. Test variables are anchor bolt diameter( do= 63.5, 76.2, 88.9mm), effective embedment depth ( hef= 635, 762mm), and edge distance( c1=381, 508, 762mm). Concrete compressive strength was constant. ( f'c= 38MPa) and anchor bolt(steel), high strength anchor bolts of ASTM A 540 class B were used. Test results as follows : Shear strengths calculated by ACI 349-06 and CCD method overestimate shear strength of large anchorage system exceeding 50mm of bolt diameter(do ). As the edge distance(c1 ) increased, the shear breakout fracture force increases. Anchor bolt diameter(do ) and effective embedment depth(hef ) have little influence on shear strength of large anchorage system, but edge distance(c1 ) is more related with shear strength of large anchorage system.
A computer program for designing optimum FIR linear phase digital filters

This paper presents a general-purpose computer program which is capable of designing a large Class of optimum (in the minimax sense) FIR linear phase digital filters. The program has options for designing such standard filters as low-pass, high-pass, bandpass, and bandstop filters, as well as multipassband-stopband filters, differentiators, and Hilbert transformers. The program can also be used to design filters which approximate arbitrary frequency specifications which are provided by the user. The program is written in Fortran, and is carefully documented both by comments and by detailed flowcharts. The filter design algorithm is shown to be exceedingly efficient, e.g., it is capable of designing a filter with a 100-point impulse response in about 20 s.
CROSS-LAYER OPTIMIZATION AND COOPERATIVE COMMUNICATIONS IN WIRELESS NETWORKS

This dissertation studies cross-layer optimization and cooperative communications in wireless networks. It consists of three main thrusts. In the first thrust, a cross-layer design approach is taken to study rate control in multi-hop wireless networks. Due to the lossy nature of wireless links, the data rate received successfully at the destination node is typically lower than the transmission rate at the source node. In light of this observation, each flow is treated as a "leaky-pipe" flow and the notion of "effective utility" is introduced. Then the rate control is explored through effective network utility maximization (ENUM). The "thinning" feature of data flows is explicitly taken into account and distributed hop-by-hop rate control algorithms are developed accordingly. The second thrust focuses on efficient data transport in wireless sensor networks, where neighboring sensor nodes are organized into coalitions and cooperative communications can be carried out. In particular, three network models are considered: 1) many-to-one sensor networks where data from one coalition are transmitted to the sink directly, 2) multi-hop sensor networks where data are relayed by intermediate nodes to reach the sink, and 3) sensor networks with data Mules which move around to cover the area and collect data from static sensor nodes. Energy efficiency, balancing, and probabilistic coverage and connectivity are investigated in this study. The third thrust is on the comparison between MIMO and SISO configurations in terms of optimal neighbor selection in multi-channel sensor networks. For each antenna configuration, two neighbor selection schemes are studied. In the scheme of first forward neighbor selection (FFNS), neighbor probing stops as soon as a neighbor with forward
Determination of the use of whey and propolis on some growth characteristics, on blood values and diarhea of the goat kids

This study was conducted to obtain an alternative more economical and healthier milk substitute feed by adding whey powder and propolis to cow's milk in goat kid rearing. 40 Saanen goat kids born in the same period and were divided into 4 groups 7 days after thei birth. The kids were divided into 4 groups 10 by 10 into control group (CG) who were kept together with their mothers and into experimental groups 1-2-3 (EG1,EG2, EG3) who were kept in seperate sections. Kids in all three experimental groups were fed only with the formula (cow milk+whey powder+water). In the EG2 and EG3, the kids were given 0. 4 cc and 0. 2 cc propolis respectively in addiditon of the formula once a day. Some growth and development parameters and rectal temperatures of the kids were measured once a week and morning and evening diarrhea scorings were taken in all groups. Some biochemical and hematological analyzes were performed. According to all the results obtained, the differences in the body temperatures and in the glucose and urea values among the groups were found to be significant and the other characteristics were statistically significant (P<0.05). The insignificant difference between the average growth and development parameters of the kids in the CGs in the CG was an important finding in growing kids more economically and reserving the goat milk for more profitable procedures. According to the diarrhea scores, it was observed that propolis was effective on diarrhea and it was concluded that it could be used in growing kids as a preventive measure. Feeding kids with the formula was found more economical than feeding them with mother-milk. As a result of this study, it could be suggested that the use of milk replacers containing whey and propolis will positively affect the growth, the development and the health of the goat’s kids.
The efficacy of okra fruit extract on the expression of transforming growth factor beta 1 in the tooth socket of diabetic Wistar rats

Background: Patients with diabetes mellitus suffer from an additional macrophage dysfunction in the secretion of growth factor, which later decreases transforming growth factor beta 1 (TGF-β1). This condition disrupts proliferation and angiogenesis. Extract of okra fruit (Abelmoschus esculentus) contains flavonoid, an active substance which acts as antioxidant, anti-inflammation, and antidiabetes. The purpose of this study is to analyze the difference in TGF-β1 expression in wound-healing process after tooth extraction of diabetic Wistar rats. Materials and Methods: This is a laboratory experimental study using pretest and posttest on 24 Wistar rats which are divided into two groups: control group (treated with streptozotocin induction but without administration of okra fruit extract) and treatment group (treated with streptozotocin induction and oral administration of 250 mg/kg okra fruit extract once a day). Extractions of the rats’ mandibular left incisors were performed using a pair of modified forceps and an elevator. The tooth sockets were then irrigated using saline solution. Four rats in each group were sacrificed on day 3 (KO1, PO1), 5 (KO2, PO2), and 7 (KO3, PO3). The socket tissues from the rats were then immunohistochemically analyzed. Data were analyzed at level significance of 0.05. Results: The average level of TGF-β1 expression in the treatment groups was higher compared to the control group: PO1 (11.59 ± 0.58), PO2 (15.15 ± 1.07), and PO3 (18.75 ± 2.73) as compared to KO1 (5.32 ± 1.69), KO2 (8.47 ± 0.60), and KO3 (9.28 ± 1.16) with P = 0.001. Conclusion: The administration of okra fruit extract can increase the level of TGF-β1 in wounds after tooth extraction of diabetic Wistar rats.
User Experience Evaluation in Mobile Industry

Context: The Telecommunication industry has experienced a great revolution since last decade. Mobile devices become the new fashion trend and play a vital role in every one´s life. Due to this reason, major industry experts predict the upcoming time to be the time of Mobile Industry. The success of mobile industry is by and large dependent on its consumers. Therefore it is necessary for the vendors to focus on their target audience i.e. what are the needs and requirements of their consumers and how they feel and perceive about their products. UX evaluation of mobile products and services (MPS) can help the organizations for developing more user friendly products and services that can meet the user expectations, needs and acceptance. Objectives: In this thesis study, one of our main focuses was to explore different definitions and concepts of UX present in academia, ISO and other standards. Also, we were interested to identify different UXEMs and the UX role in mobile industry in order to develop a better understanding about the importance of UX in the success of Mobile products and services (MPS). Methods: An exploratory case study was carried out to answer the research questions of this thesis study. At the end, the results of the case study were evaluated from a workshop, held at Ericsson AB (Karlskrona). On the basis of case study and workshop, final results are presented. Results: During this thesis study, we have proposed an initial framework to understand UX. We have also proposed a toolkit of UXEMs that can provide guideline about UXEMs i.e. which UXEM is suitable for which factor of UX and during which phase of development life cycle. Conclusions: In academia (literature), different definitions and terminologies are present for UX but still no consensus is found on one single definition of UX. In academia, different authors have identified different UX factors that may influence the UX in adoption of MPS. Through Case Study, we identified different UXEMs and UX evaluation criteria that are used to capture the UX. We have presented different UX factors that need to be focused for evaluating UX in Mobile Industry. We conclude that there is a need of such UXEM or UXEMs that can capture the broader picture of UX as most of the identified UXEMs were only useful to measure some of the UX factors. After conducting workshop at Ericsson AB (Karlskrona), we conclude that there is need to make industry and academia more closer for developing good understanding about UX i.e. still industry people are not much familiar with different UXEMs and UX factors .
Nanoparticle Systems for Cancer Phototherapy: An Overview

Photodynamic therapy (PDT) and photothermal therapy (PTT) are photo-mediated treatments with different mechanisms of action that can be addressed for cancer treatment. Both phototherapies are highly successful and barely or non-invasive types of treatment that have gained attention in the past few years. The death of cancer cells because of the application of these therapies is caused by the formation of reactive oxygen species, that leads to oxidative stress for the case of photodynamic therapy and the generation of heat for the case of photothermal therapies. The advancement of nanotechnology allowed significant benefit to these therapies using nanoparticles, allowing both tuning of the process and an increase of effectiveness. The encapsulation of drugs, development of the most different organic and inorganic nanoparticles as well as the possibility of surfaces’ functionalization are some strategies used to combine phototherapy and nanotechnology, with the aim of an effective treatment with minimal side effects. This article presents an overview on the use of nanostructures in association with phototherapy, in the view of cancer treatment.
Analysis of geodesic lens excited by an array of sources with uniform amplitude

Electromagnetic lenses have been applied since early 1950s as a means of obtaining electronic steerable antennas. One weakness of a conventional lens, however, is the fact that only one feed point can be used at a time, in order to generate a single beam in the radiated field. The purpose of this paper is to propose a kind of geodesic lens with an uniform distribution of feeders along the lens input, being all the feeders used at all times, for any direction of the output beam. Therefore, all the feeding points contribute equally to the total radiated power and electronic steering can be obtained by properly setting only the phases of the several supplies at the input of the lens.
The Site Effect Analysis of Semi-Cylindrical Canyons and Soft Alluvial Basins by H/V Spectral Ratio

The source, path and site effects are the main causes for ground motions. Soft alluvial basins especially result in seismic wave amplification as the site effect. Irregular alluvial basins and canyons in this study are semi-cylindrical for simplifying analysis. To deal with the scattering problems in frequency domain, Yeh et al. have gained positive outcomes by using a hybrid method which combined finite elements and the series expansion method to effectively solve the scattering problem in the irregular basins. These displacements derived from the frequency domain are computed with the H/V ratio to estimate the site effect. As the site effect is crucial in earthquake engineering, this study may serve as a quantitative contribution towards the amplified effect in alluvial basins and canyons. It can also simulate the effects of different incident angles on the H/V ratio.
Managing product variety in multinational corporation supply chains

Purpose – For manufacturing enterprises, today's business environment is characterised by globally dispersed supply and manufacturing networks. In addition, the level of variety in products continues to increase in almost all sectors. Greater understanding of the management of product variety in international operations is required. Aims to discuss this issue.Design/methodology/approach – A generic simulation model representing a multinational corporation (MNC) supply chain is used to investigate the impact on supply chain performance of increasing product variety in combination with supply lead‐time and demand uncertainty in an international setting. The simulation focuses on the upstream activities of production planning, inbound supply and manufacturing. The structure and logic of the simulation model are based on insights obtained from an empirical study of real MNC supply networks.Findings – The study shows that increasing the level of product variety has a detrimental impact on supply chain performa.
Carbon Neutrality Ambitions and Reinforcing
Energy Efficiency Through OFDI Reverse
Technology Spillover: Evidence from China

Carbon neutrality is the only way for green low-carbon development. Technological progress is an important starting point for improving energy efficiency. Through scientific and technological innovation, improving energy efficiency is a practical way to achieve the goal of carbon neutralization. Due to the limitation of data and index selection, there is no qualitative analysis of carbon neutrality in this paper. Compared with previous studies, the paper has the following contributions: Firstly, the energy efficiency score of China’s provincial level is measured with the DEA method and it is found that the average energy efficiency score of the eastern region is the highest, followed by the western region, and finally the central region. The results also show that the energy efficiency is not in accordance with the economic growth. The regions with higher energy efficiency scores are not always economically developed because of huge energy consumption supporting the economic development. Secondly, the Tobit method is used to study the impact of the reverse technology spillover effect of OFDI on China’s energy efficiency. The results show that the spillover effect has a significant positive effect on the improvement of China’s energy efficiency, and has a positive impact on the eastern and western regions, but has no significant impact on the western region. Finally, we put forward some policy recommendations to increase energy efficiency to approach carbon neutrality and thus promote green economic development. This paper enriches the content of energy economy, the research method is innovative, and the conclusion is more scientific.
Coordinated scheduling of energy resources for distributed DHCs in an integrated energy grid

As more and more distributed renewable energy resources connected to electric power grids, the conventional power system evolves into an integrated energy grid (lEG) in order to satisfy various types of energy demands. This paper proposes a model of the coordinated scheduling of energy resources (CSoERs) for distributed district heating and cooling systems (DHCs) in an lEG. The model takes into consideration both the dispatchable grid-connected generators and distributed renewable energy resources, such as wind energy, solar energy and natural gas. The objective is to minimize the operation costs in the lEG in order to satisfy not only the electrical loads but also the heating loads and cooling loads. Furthermore, an energy storage system for heating loads and cooling loads is also developed in the DHCs to improve the operation reliability in the distributed DHCs. Detailed simulation studies are carried out to verify the effectiveness of the CSoERs under two different operation scenarios: grid-connected scenario and stand-alone scenario. Simulation results demonstrate that the performance of the CSoERs contributes to significant energy saving and reliability operation in both grid-connected scenario and standalone scenario in the lEG.
Regimes of Contact in Spline Couplings

The contact between the male and female teeth of involute spline couplings connecting misaligned transmission shafts has been studied using an elastostatic contact model with stick-slip friction based on the boundary integral element method. The effect on the distribution of pressure and on the slip path during shaft rotation, of a wide range of design parameters and of applied torque and misalignment has been explored. The predicted behavior is classified according to the regime of friction (cyclic stick-slip or gross slip) and to that of the pressure history (uniform, cyclic, discontinuous, or toppled). The magnitude of the maximum tooth load, the axial skewness of the distribution of pressure and a maximum wear depth parameter are presented in terms of dimensionless design and operating parameters. The effect of tooth crowning is briefly examined. The results show a number of previously unreported features including a cyclic tooth load-which declines to zero for certain conditions-and an effective slip amplitude of around half the rigid-body value. This may affect the interpretation of laboratory fretting tests.
An Economic Map of Cybercrime

The rise of cybercrime in the last decade is an economic case of individuals responding to monetary and psychological incentives. Two main drivers for cybercrime can be identi fied: the potential gains from cyberattacks are increasing with the growth of importance of the Internet, and malefactors' expected costs (e.g., the penalties and the likelihood of being apprehended and prosecuted) are frequently lower compared with traditional crimes. In short, computer-mediated crimes are more convenient, and pro table, and less expensive and risky than crimes not mediated by the Internet. The increase in cybercriminal activities, coupled with ineff ective legislation and ineffective law enforcement pose critical challenges for maintaining the trust and security of ourcomputer infrastructures.Modern computer attacks encompass a broad spectrum of economic activity, where various malfeasants specialize in developing speci c goods (exploits, botnets, mailers) and services (distributing malware, monetizing stolen credentials, providing web hosting, etc.). A typical Internet fraud involves the actions of many of these individuals, such as malware writers, botnet herders, spammers, data brokers, and money launderers.Assessing the relationships among various malfeasants is an essential piece of information for discussing economic, technical, and legal proposals to address cybercrime. This paper presents a framework for understanding the interactions between these individuals and how they operate. We follow three steps.First, we present the general architecture of common computer attacks, and discuss the flow of goods and services that supports the underground economy. We discuss the general flow of resources between criminal groups and victims, and the interactions between diff erent specialized cybercriminals.Second, we describe the need to estimate the social costs of cybercrime and the profi ts of cybercriminals in order to identify optimal levels of protection. One of the main problems in quantifying the precise impact of cybercrime is that computer attacks are not always detected, or reported. Therefore we propose the need to develop a more systematic and transparent way of reporting computer breaches and their eff ects.Finally, we propose some possible countermeasures against criminal activities. In particular, we analyze the role private and public protection, and the incentives of multiple stake holders.