Miracle-dz/UniFAR-FTUs huggingface dataset:
The effect of emotional eating on body weight and eating habits in adults

The aim of this study is to evaluate the effect of emotional nutrition on body weight and eating habits in adults. 2461 volunteers between the ages of 18-and 65 (40.7±13.6 years) participated in this cross-sectional study (M=677, F=1784). Research data were collected with a face-to-face questionnaire. The participants' nutritional habits and status were evaluated with the three-factor eating questionnaire (TFEQ) and a 24-hour dietary recall form. The “International Physical Activity Assessment Questionnaire - Short Form” was used to determine the physical activity level of individuals. Body mass index was calculated by measuring height and body weight. At the end of the study, it was found that 34.5% of the participants were overweight, and 25.1% were obese. The uncontrolled eating and hunger score were significantly higher, whereas it was low in cognitive restraint in individuals who consumed grains as much or more than recommended (p<0.05). And higher cognitive restraint score was found in those who stated that they consumed the milk and dairy products, vegetable and fruit groups as much or more than recommended and the grains less than recommended (p<0.05). In addition, dietary disinhibition (OR=1.142, 95% CI=1.097-1.189), cognitive restriction (OR=1.076, 95% CI=1.050-1.103) and fasting (OR=1.084, 95% CI=1.033-1.137) scores of TEFQ sub-factors been shown to significantly increase the risk of being overweight/obese (p<0.001). These results show that emotional eating has a significant effect on body weight. For this reason, a multidisciplinary approach is required to evaluate the effect of diet therapy and nutrition on the patient and take into account the patient's emotional state, especially in the treatment and control of obesity.
Cancer Metabolism and Ischemia-Reperfusion Injury: Two Sides of the Same Coin

Cancer cells are characterized by the reprogramming of certain cell metabolisms via activation of definite pathways and regulation of gene signaling. Ischemia-reperfusion injury (IRI) is characterized by tissue damage and death following a lack of perfusion and oxygenation. It is most commonly seen in the setting of organ transplantation. Interestingly, the microenvironments seen in cancer and ischemic tissues are quite similar, especially due to the hypoxic state that occurs in both. As a consequence, there is genetic signaling involved in response to IRI that has common pathways with cancer. Some of these changes are seen across the board with many cancer cells and are known as Hallmarks of Cancer, among which are aerobic glycolysis and the induction of angiogenesis. This literature review aims to compare the metabolic pathways that are altered in cancer tissues and in normal tissues subjected to IRI in order to find common adaptive processes and to identify key pathways that could represent a therapeutic target in both pathologies. By increasing our understanding of this relationship, clinical correlations can be made and applied practically to improve outcomes of transplanted organs, given the known association with acute rejection, delayed graft function, and poor graft survival. The following metabolic pathways are discussed in our review, both in the setting of cancer and IRI: apoptosis, glycolysis, and angiogenesis. The role of the immune system in both pathologies as well as mitochondrial function and the production of reactive oxygen species (ROS) are reviewed.
Development of gastro retentive microbeads for sustained release of fexofenadine and montelukast

In allergic rhinitis, montelukast (leukotriene receptor antagonist) in combination with fexofenadine (antihistamine) provide improved and complimentary effects and reduce the allergic symptoms effectively. Montelukast has less bioavailability due to hepatic first pass metabolism and fexofenadine have low permeability. So sustained release delivery is crucial for these drugs. One of the techniques to overcome this challenge is the development of polymeric microspheres or microbeads for enhanced bioavailability and prolong the action of drug in body. The objective of the study is to produce a potential microencapsulated formulation having the combination of fexofenadine hydrochloride and montelukast sodium. Microbeads were formulated by using polymer, eudragit RS100. Single emulsion solvent evaporation method was used for the preparation of formulation. The developed drug loaded polymeric microbeads showed that percentage floating ranged from 82.1 - 90.4%. Entrapment efficiency of microbeads were found between 68.8- 80.9%. FTIR results revealed absence of drug-polymer interaction. In-vitro release studies shown that from all the prepared formulations of both drugs the optimum formulation was released up to 24hrs and percentage cumulative drug release was 87.40% and 89.78% respectively. The acute toxicity study showed the safety of the developed system. Formulated microbeads were significantly efficient to achieve a sustained release of fexofenadine and montelukast with prolonged therapeutics release up to 24 hours. The developed gastro retentive floating drug delivery systems showed excellent physicochemical properties and sustained drug release pattern, thereby improving the bioavailability of the drugs.
The Use of Mechanical Ventilation Support at the End of Life in Motor Neurone Disease/Amyotrophic Lateral Sclerosis: A Scoping Review

There has been an increase in the use of mechanical ventilation (MV) in motor neurone disease (MND) to alleviate symptoms related to hypoventilation. Little is known about its use at the end of life, and the withdrawal of MV is a challenging topic. A scoping review was conducted to map the existing evidence of ventilation use at the end of life in MND. The Joanna Briggs Institute methodological framework was used, and a total of 31 documents were included in the data extraction. Boarder themes around place, planning, cause and comments on death were identified. Our findings show that the focus of the literature has been on the process of the withdrawal of ventilation, creating the subthemes of timing and reason for withdrawal, along with ethical, emotional, and practical issues, medications used and the time until death. There is a foundation of evidence to guide the process and discuss the ethical and emotional issues of withdrawing ventilation. However, there remains limited evidence from patient and family member perspectives. Importantly, there is almost no evidence exploring dying with ventilation in place, the active or passive decisions around this process, how the interface might impact the dying process, or what families think about this.
CircRNA_0050486 promotes cell apoptosis and inflammation by targeting miR-1270 in atherosclerosis

Background Atherosclerosis (AS) is a chronic inflammatory disease that plays a major role in cardiovascular disease. Circular RNAs (circRNAs) are related to the pathogenesis of AS, including the inflammatory response. This study aimed to explore the underlying mechanisms of circRNAs and how they regulate the inflammatory response in AS. Methods Analyzed the expression profile of circRNAs in three oxidized low-density lipoprotein (oxLDL) treated macrophage samples and three macrophage control samples using bioinformatics methods. Expression and biological function of circRNA were verified in oxLDL-induced THP-1 macrophages. MiRNAs and target genes of circRNA were predicted by functional enrichment analysis. Expression and function of circRNA target miRNAs were explored in oxLDL-induced THP-1 macrophages. Finally, we predicted and analyzed the function of circRNAs-miRNAs target genes in AS. Results We identified nine upregulated circRNAs and found that circ_0050486 was significantly upregulated in a THP-1 + PMA + oxLDL group compared with a THP-1 + PMA group. Additionally, circ_0050486 knockdown markedly inhibited IL-6 and TNF-α concentrations and the cell death rates in oxLDL-induced THP-1 macrophages. Furthermore, circ_0050486 targeted and inhibited miR-145 and miR-1270. Upregulated miR-1270 markedly inhibited IL-6 and TNF-α levels and the cell death rates in oxLDL-induced THP-1 macrophages. Finally, the target genes of miR-1270 and miR-145 were predicted by the miRDB, miRWalk, and Targetscan databases, and a functional analysis network of the target genes was constructed by Cytoscape GlueGO, including the regulation of the immune response and monocyte chemotaxis. The common target genes of miR-145 and miR-1270 were established by Cytoscape and included NF1A, among others. Conclusions Our study suggested that circ_0050486 knockdown inhibited inflammation and apoptosis by targeting miR-1270 in oxLDL-induced THP-1 macrophages. This finding may provide a potential therapeutic target for atherosclerosis.
Drought tolerance in F1 interspecific hybrid between, Solanum melongena and its wild ancestor, Solanum insanum

The need for improved aubergine varieties is increasing because of climate change’s effects such as drought. To solve this problem, the use of wild ancestor of aubergine, Solanum insanum, as a source of genes seems appropriate since this species is found in various climates. The objective was to obtain aubergine genotypes with genes from the wild species, S. insanum, giving them the ability to adapt to drought. Drought tolerance of accessions from Solanum melongena and Solanum insanum and their F1 progeny was assessed using 16 phenotypic descriptors. Variance and genetic parameters (heritability (h2), genotypic (GCV) and phenotypic (PCV) coefficients of variation, correlations) relating to growth dynamics were estimated. F1 hybrids exhibited better drought tolerance abilities than parental accessions. The values of floral characteristics of these hybrids were higher in dry season. This favoured reproduction at expense of vegetative growth. Finally, high differences between GCV and PCV corroborated by low values of h2 show that plant selection based on growth dynamics would be ineffective for improving aubergine against drought. Development of plant organs determined by genes with pleiotropic effects is reflected by contrasting values of genotypic and phenotypic correlations.
Facial Expression Recognition Based on Improved Residual Block Network

Facial expression recognition is widely used, but there are some problems such as complex scenes, lack of data sets and low recognition rate. In this paper, we construct a new network model and name it RNFC. The RNFC network adopts 6 improved residual blocks to extract features. Features are passed into the fully connected layer by flattening the data, and Dropout techniques are introduced between the fully connected layers to prevent overfitting of the model. Based on the pytorch framework, we use a cross-entropy loss function to improve the training speed of the network. And perform denoising and enhancement pre-processing on the FER2013 dataset. The RNFC network is trained and tested on the pretreated FER2013. It has a higher recognition rate than classical networks such as VGGnet19 and ResNet18.
A Roadmap for Designing Extended Reality Tools to Teach Unit Operations in Chemical Engineering: Learning Theories & Shifting Pedagogies

This paper explores the impact of shifting from paper-based to eXtended Reality (XR) teaching tools and is informed by a design project that took place at the Chemical Engineering department at the Technical University of Denmark (DTU.CBE). The authors believe that, for operator training, teaching methods that leverage exploring, constructing and experiencing are superior to traditional teaching methods that rely heavily on conceptualising and rationalising. Cognitive load theory is used to focus this pedagogic discussion on memory. Thereafter, a neuroscience model called SULEX is employed to decompose memory into four related cognitive functions, Perception, Instinct, Reflection and Intuition, and for mapping our learning activities to Bloom ’ s Taxonomy. Thereafter, another model is presented to illustrate a range of teaching discourses that can be consulted for designing XR tools for instructional purposes. For operator training, we have recommended spatial reasoning, affordance theory, distributed cognition and situated learning, among others. Finally the insights derived from the cognitive and instructional analysis will be illustrated in the presentation of several design features that were implemented as part of a Virtual Reality instructional design project at DTU.CBE.
Exploring Cultural Schemas in Foreign Language Education Policy (FLEP) Documents of Iran

Culture is an indispensable part of Foreign Language Education Policy (FLEP), especially in English Language Teaching (ELT). In addition, the spread of English around the globe has resulted in English users‟ tendency to embed their local culture in their English communication (Kirkpatrick, 2012). However, literature remains silent on culture representation in FLEP, especially in an ideologized country like Iran. To address this issue, due to lack of an explicit FLEP in Iran, the present study analyzed the cultural schemas addressed in the seven major national policy documents of Iran, namely 20-year National Vision, Comprehensive Science Roadmap, Support for Comprehensive Science Roadmap in the Domain of Languages, Cultural Engineering Document, National Curriculum, Fundamental Reform in Education, and Islamicization of Universities. Results of content analysis using MAXQDA Software unmasked Islamic-Iranian culture as the baseline for ELT in Iran. In order to further examine the representations and implications of „Islamic-Iranian culture‟ hidden in the documents, open coding, axial coding, and labeling along with constant comparative procedure revealed various Islamic cultural schemas. However, very few instances of Iranian cultural schemas were unveiled. The findings were discussed in light of the hidden curriculum and the power relations behind the extracted cultural schemas
Inflammatory markers in patients who presented with acute coronary syndrome and history of COVID-19 infection: a cross-sectional study

Background: During the COVID-19 outbreak, the number of patients who have developed acute coronary syndromes (ACS) has soared rapidly, cardiovascular disease and mortality are influenced by the elevated inflammatory biomarkers. The aim of this study is to compare inflammatory markers between patients with ACS who hadn’t previously had COVID-19 and those who’d be infected within the preceding three months; as well as, evaluating the effect of statins on inflammatory biomarkers. Methods: This is a comparative cross-sectional study of 42 patients who presented with ACS and had previously had COVID-19 and 48 patient who had never had COVID-19, who were admitted to the coronary care unit at the Iraqi Center for Heart Disease and Baghdad Teaching Hospital, Iraq. Inflammatory biomarkers (TNF-α, IL-6, and HS-CRP) levels were determined in serum samples of all patients at admission to these centers then one month later, after administration of statins daily using the Sandwich-ELISA Principle, and Immunofluorescence technique for these markers. Result: The baseline for patients who had ACS and COVID-19 three months previously, were IL6 (85.87 ±45.80), HS-CRP (23.19 ± 14.49), and TNF-α (161.94± 240.96) were higher than patients that had ACS but not COVID-19; IL6 (50.77±22.48), HS-CRP (13.64± 12.09), and TNF-α (117.73 ±71.23),(p<0.0001), (p=0.003) and (p=0.201) for IL6, HS-CRP, and TNF-α respectively. Rosuvastatin showed a significant reduction in HS-CRP and IL6 (P<0.001), while Atorvastatin a significant reduction in HS-CRP (P<0.001) after one month of therapy. Yet there was no significant difference in the level of TNF α in these two groups at the end of this study. Conclusions: The patients with previous COVID-19 still had higher inflammatory markers than those who didn’t. Rosuvastatin 40mg had a more reduction in IL6 than Atorvastatin 40mg after one month and both of them could reduce HS-CRP, but neither could reduce TNF-α in this short period.
Mutual Decoupling for Massive MIMO Antenna Arrays by Using Triple-Layer Meta-Surface

The high isolation massive antenna arrays are the key devices in the base station of the future wireless communication systems. The challenge for the array application is how to reduce the coupling among the array elements. This paper introduces a new decoupling method for massive MIMO arrays with an inner-element distance of around half wavelength by using a triple-layer metasurface (TMS). The TMS comprises three identical surfaces. The waves reflected from the bottom metasurface (MS) and top two-layer MS have the same amplitudes and the opposite phases, which are canceled with each other. An example of $4\times 4$ dual-polarized wideband microstrip array with a TMS is proposed to verify the decoupling method. The simulation and measurement show that the TMS can help reduce the coupling among the array elements to less than −24 dB in both the co-polarization and cross-polarization directions within 4.23-4.82 GHz. In the meanwhile, the radiation characteristics of the arrays with and without TMS are almost unchanged.
Even Patients with Very Chronic Symptoms of Greater Trochanteric Pain Syndrome (GTPS) may Report Improvements Following Radial Extracorporeal Shockwave Therapy (rESWT), but no Single Baseline Factor Predicts Response

411 SUMMARY Objective. Do any measures at baseline predict response from radial Extracorporeal Shockwave Therapy (rESWT) for patients with GTPS? Methods. Setting: single UK NHS Sports Medicine Clinic. Patients: 260 patients following rESWT for GTPS. Mean age 60.0 ± 11.9 years, 81% female, mean duration of symptoms 44.5 ± 44.7 months (range: 3 months-20years). Interventions: participants received three sessions of rESWT plus structured home exercise programme (flexibility, strength, and balance). Main outcome measures: follow-up was 3-months, and 6-months. Outcome measures of self-reported “average pain”, “worst pain”, and VISA-G score. Baseline PROMS (Non-Arthritic Hip score, and Oxford Hip Score), pain (painDETECT, S-LANSS, CSI), “ability” (ODI, MSK-HQ), mood (HADS). Results. Improvement in “average pain” of 30% at 3-months, and 37% at 6-months. VISA-G improved by more than 10% points at 3-months and 6-months. Several weak or very-weak correlations were identified, but no single baseline variable corelated strongly to the improvements seen at follow-up time-points. Conclusions. There were clinical and statistically-significant improvements seen following rESWT for patients with GTPS, even in those with very long duration of symptoms, irrespective of age or symptom duration. There was a statistically significant difference for gender (greater benefit in female patients) which did not reach clinical significance. Greatest improvements in self-reported pain were seen in those with the worst baseline symptoms, particularly with variables more sensitive to non-arthritic hip pain (NAHS, VISA-G) than “arthritic pain” measures (OHS). Baseline measures such as Oswestry Disability Inventory or the MSK-HQ have weak correlations to improvements in some factors seen, with fewer correlations seen for markers of chronic, neuropathic, or centralised pain, or mood.
BLAST WAVE PHYSICS: Conspiracy or coincidence? An amusing footnote to the saga of Manhattan Project espionage

This article is a report of thoughts and actions of the author. Therefore, when referring to the author, the pronoun, I, or, me, will frequently be used. Whether or not this conforms to formal usage, it is believed that it will make the meanings of the paper clearer than if another construction were used. When it is necessary to refer to others, an attempt will be made to make clear the identity of the person being described.
COMMENT: Ising model with third-neighbour interactions on the Cayley tree

The authors formulate the Ising model with competing first-, second- and third-neighbour interactions along the branches of a Cayley tree, in the infinite coordination limit, as a three-dimensional non-linear mapping problem. The phase diagrams display a Lifshitz point and many modulated phases. The introduction of third-neighbour interactions affects mainly the low-temperature region of the phase diagrams.
Preservation of Orbital Forcing in Intraplatform Carbonates and an Astronomical Time Frame for a Multiproxy Record of End-Triassic Global Change from a Western Tethyan Section (Csővár, Hungary)

High temporal resolution is of paramount importance in stratigraphic studies of major events in earth history such as the end-Triassic extinction (ETE). Although it ranks among the most severe Phanerozoic mass extinctions, the precise timing and duration of the cascade of environmental and biotic changes across the Triassic-Jurassic boundary (TJB) interval remains controversial. Here we present a cyclostratigraphic study of the Csővár section (Hungary), a continuous carbonate succession from an intraplatform basin that yielded significant geochemical and paleontological data from around the TJB. We analyzed ten elemental time series and stable isotope data series and detected cyclicities with periodicities similar to the orbital cycles of the ~405 kyr long and ~124 kyr short eccentricity, the ~34 kyr obliquity, and the ~17–21 kyr precession. The astrochronologic age model suggests that the ~52 m thick section was deposited in 2.9–3 Myr, with an average sedimentation rate of 1.73–1.79 cm/kyr. We establish that the section contains the last ~1.3 million years of the Rhaetian and most of the Hettangian, supporting a <2 Myr duration for this stage. The duration of the initial carbon isotope anomaly (ICIE) is estimated at ~40–80 kyr. Previously recognised meter-scale sequences are in agreement with the long eccentricity cycles up to the level of the ICIE but subsequently this relationship becomes less clear, possibly reflecting the effects of the end-Triassic climatic/environmental perturbations and associated changes in the depositional environment superimposed onto overarching astronomical forcing. We propose a cyclicity-based environmental model for sedimentation in the Csővár basin where the observed antiphase behaviour of the carbonate accumulation and the terrigenous input and dissolved silica was driven by a combination of aquiferand limno-eustasy and the ̋megamonsoon̋ system that dominated the climate of the peri-Tethyan realm. This study highlights that intraplatform carbonate successions can be suitable archives to preserve orbital cyclicities and the new astrochronological age model helps improve our understanding of the ETE and other events in the