Miracle-dz/UniFAR-FTUs huggingface dataset:
Meteorological Analysis Systems in North-East Spain: Validation of SAFRAN and SPAN

We present an application and validation of the SAFRAN meteorological analysis system for north-east Spain. SAFRAN is also compared to the SPAN analysis system and the meteorological model HIRLAM-HNR, both operational at AEMET. This application of SAFRAN is intended for hydrological studies. This is the first study that shows an application of SAFRAN outside of France and that compares it with SPAN. This is also the first article validating SPAN's rainfall values. Using one year of observational data, the results show that both SAFRAN and SPAN have a similar performance, which is also similar to SAFRAN's performance in France. Thus, SAFRAN and SPAN are both good tools to force land surface models at high resolution in the area of SAFRAN works under the assumption of the existence of climatically homogeneous zones. Two different sets of zones were tested, one based on the AEMET meteorological warning zones and another one based on hydrological catchments. Better results were obtained when using meteor-ological warning zones. However, the difference is small. In north-east Spain, SAFRAN has the same limitations that were previously shown in France: the spatial structure of the fields is not realistic enough and wind speed is underestimated. As expected, both SAFRAN and SPAN work better in flat areas than over areas of steep relief. This can be a problem in hydrological studies, especially for the Ebro river basin, where most of the runoff is generated in the Pyrenees.
Novel Antioxidant Collagen Peptides of Siberian Sturgeon (Acipenser baerii) Cartilages: The Preparation, Characterization, and Cytoprotection of H2O2-Damaged Human Umbilical Vein Endothelial Cells (HUVECs)

For making full use of aquatic by-products to produce high value-added products, Siberian sturgeon (Acipenser baerii) cartilages were degreased, mineralized, and separately hydrolyzed by five kinds of proteases. The collagen hydrolysate (SCH) generated by Alcalase showed the strongest 2,2-diphenyl-1-picrylhydrazyl radical (DPPH·) and hydroxide radical (HO·) scavenging activity. Subsequently, thirteen antioxidant peptides (SCP1-SCP3) were isolated from SCH, and they were identified as GPTGED, GEPGEQ, GPEGPAG, VPPQD, GLEDHA, GDRGAEG, PRGFRGPV, GEYGFE, GFIGFNG, PSVSLT, IELFPGLP, LRGEAGL, and RGEPGL with molecular weights of 574.55, 615.60, 583.60, 554.60, 640.64, 660.64, 885.04, 700.70, 710.79, 602.67, 942.12, 714.82, and 627.70 Da, respectively. GEYGFE, PSVSLT, and IELFPGLP showed the highest scavenging activity on DPPH· (EC50: 1.27, 1.05, and 1.38 mg/mL, respectively) and HO· (EC50: 1.16, 0.97, and 1.63 mg/mL, respectively), inhibiting capability of lipid peroxidation, and protective functions on H2O2-damaged plasmid DNA. More importantly, GEYGFE, PSVSLT, and IELFPGLP displayed significant cytoprotection on HUVECs against H2O2 injury by regulating the endogenous antioxidant enzymes of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) to decrease the contents of reactive oxygen species (ROS) and malondialdehyde (MDA). Therefore, the research provided better technical assistance for a higher-value utilization of Siberian sturgeon cartilages and the thirteen isolated peptides—especially GEYGFE, PSVSLT, and IELFPGLP—which may serve as antioxidant additives for generating health-prone products to treat chronic diseases caused by oxidative stress.
Passive Seismic Surveys for Beach Thickness Evaluation at Different England (UK) Sites

In an era of environmental change leading to rising sea levels and increased storminess, there is a need to quantify the volume of beach sediment on the coast of Britain in order to assess the vulnerability to erosion using cheap, easy-to-deploy and non-invasive methods. Horizontal-to-vertical spectral ratio (HVSR) is a technique that uses the natural background seismic ‘noise’ in order to determine the depth of underlying geological interfaces that have contrasting physical properties. In this study, the HVSR technique was deployed at a number of settings on the coast of England that represented a range of different compositions, geomorphology, and underlying bedrock. We verified the results by comparison to other survey techniques, such as ground-penetrating RADAR, multichannel analysis of surface waves (MASW), and cone penetration tests. At locations where there was sufficient contrast in physical properties of the beach material compared to the underlying bedrock, the beach thickness (and therefore the volume of erodible material) was successfully determined, showing that HVSR is a useful tool to use in these settings.
Data Protection Software for Civil Aviation Control Flight Information System Based on FPE Algorithm

This study is aimed in order to study the data protection software of civil aviation management flight information system based on FPE algorithm. The author established the data warehouse software of the air traffic control production information statistics system. First, using the Jquery browser application framework + service-oriented Web Service architecture technology, a B/S/S multilayer data application based entirely on browser applications is established. Then, with the support of the ATC production information statistical data warehouse software and the system application framework, the system realizes a series of production data processing related to production information management, such as data collection, data editing, data review, and business data statistics. Finally, combined with the attributes of business data, we analyze and compare all kinds of production information from multiple dimensions such as time and region; it also provides users with data analysis results of curve, pie, column, and other performance situations, display mode, and report output tool. SQL statement can be implemented to add data to the database, modify the existing data in the database, delete the existing data in the database, and can be queried in a variety of ways to the data in the database, and VB provides a human-computer interaction interface for various operations.
Off-Label Use of Botulinum Toxin in Dermatology—Current State of the Art

Botulinum toxin (BoNT) is a neurotoxin produced by the Clostridium botulinum bacteria. Among seven different isoforms, only BoNT-A and BoNT-B are commercially used. Currently, botulinum toxin has been indicated by the U.S. Food and Drug Administration in several disorders, among others: chronic migraine, hyperhidrosis, urinary incontinence from detrusor overactivity, or cosmetics. However, there are numerous promising reports based on off-label BTX usage, indicating its potential effectiveness in other diseases, which remains unknown to many. Among them, dermatological conditions, such as rosacea, annal fissure, Raynaud phenomenon, hypertrophic scars and keloids, and also hidradenitis suppurativa, are currently being investigated. This article aims to provide a comprehensive update on the off-label use of botulinum toxin in dermatology, based on an analysis and summary of the published literature.
Integrative taxonomy and phylogeny of leafless Vanilla orchids from the South‐West Indian Ocean region reveal two new Malagasy species

The leafless Vanilla species complex from the South‐West Indian Ocean (SWIO) region has long been a taxonomic challenge, due to limited patterns of morphological differentiation and an absence of variation within chloroplast sequences. This complex includes seven known morphospecies: V. madagascariensis, V. bosseri, V. decaryana, and V. perrieri endemic to Madagascar, V. humblotii presumed as endemic to the Comoros Archipelago, but also present in Madagascar, V. roscheri from the East African coast, and V. phalaenopsis endemic to Seychelles. A previous population genetic study using microsatellite markers allowed us to distinguish, in addition to the five recognized Malagasy taxa, two other genetic clusters present in the East of the island. An integrative taxonomy approach was therefore conducted by combining microsatellite and morphological data used in the previous study with new data sets, and by adding ITS sequencing data, to validate the taxonomic level of these Malagasy genetic clusters and unravel phylogenetic relationships between SWIO species. As a result, based on phylogenetic, genotypic and morphological evidence, nine species were discriminated in the SWIO region, including seven in Madagascar, with two new eastern species. The leafless Vanilla group originated and diversified in Madagascar, from an ancestor of African descent, with three subsequent independent colonization events from Madagascar to the other territories of SWIO within the two main lineages (white versus yellow flower species). The new Malagasy species, V. allorgeae Andriamihaja & Pailler sp. nov., and V. atsinananensis Andriamihaja & Pailler sp. nov., are described and a new identification key is proposed.
Identification and Transcriptome Analysis of Genes Related to Membrane Lipid Regulation in Sweet Sorghum under Salt Stress

Sweet sorghum has strong stress resistance and is considered a promising energy crop. In the present study, the effects of salt on the membrane lipid metabolism of two sweet sorghum inbred lines (salt-tolerant M-81E and salt-sensitive Roma) were analyzed. After treatment with 150 mM NaCl, higher levels of fresh weight and chlorophyll fluorescence, as well as lower levels of malondialdehyde (MDA) were found in salt-tolerant M-81E. Concomitantly, 702 and 1339 differentially expression genes (DEGs) in M-81E and Roma were identified in response to salt stress. We determined that most DEGs were related to glycerophospholipid metabolism, glycerolipid metabolism, and other membrane lipid metabolisms. Under NaCl treatment, the expression of the membrane-associated phospholipase A1 was down-regulated at the transcriptional level, along with an increased content of phosphatidylcholine (PC) in both cultivars. The inhibition of triacylglycerol (TAG) mobilization in M-81E delayed salt-induced leaf senescence. Furthermore, enhanced levels of glycerol-3-phosphate acyltransferase (GPAT) expression contributed to improved salt resistance in M-81E. The results of this study demonstrate membrane the role of lipid regulation in mediating salt-defensive responses in sweet sorghum and expand our understanding of the relationship between changes in membrane lipid content and salt resistance.
Diagnostic and Therapeutic Perspectives Associated to Cobalamin-Dependent Metabolism and Transcobalamins’ Synthesis in Solid Cancers

Cobalamin or vitamin B12 (B12) is a cofactor for methionine synthase and methylmalonyl-CoA mutase, two enzymes implicated in key pathways for cell proliferation: methylation, purine synthesis, succinylation and ATP production. Ensuring these functions in cancer cells therefore requires important cobalamin needs and its uptake through the transcobalamin II receptor (TCII-R). Thus, both the TCII-R and the cobalamin-dependent metabolic pathways constitute promising therapeutic targets to inhibit cancer development. However, the link between cobalamin and solid cancers is not limited to cellular metabolism, as it also involves the circulating transcobalamins I and II (TCI or haptocorrin and TCII) carrier proteins, encoded by TCN1 and TCN2, respectively. In this respect, elevations of B12, TCI and TCII concentrations in plasma are associated with cancer onset and relapse, and with the presence of metastases and worse prognosis. In addition, TCN1 and TCN2 overexpressions are associated with chemoresistance and a proliferative phenotype, respectively. Here we review the involvement of cobalamin and transcobalamins in cancer diagnosis and prognosis, and as potential therapeutic targets. We further detail the relationship between cobalamin-dependent metabolic pathways in cancer cells and the transcobalamins’ abundancies in plasma and tumors, to ultimately hypothesize screening and therapeutic strategies linking these aspects.
Superconducting Bio-Inspired Au-Nanowire-Based Neurons

High-performance modeling of neurophysiological processes is an urgent task that requires new approaches to information processing. In this context, two- and three-junction superconducting quantum interferometers with Josephson weak links based on gold nanowires are fabricated and investigated experimentally. The studied cells are proposed for the implementation of bio-inspired neurons—high-performance, energy-efficient, and compact elements of neuromorphic processor. The operation modes of an advanced artificial neuron capable of generating the burst firing activation patterns are explored theoretically. A comparison with the Izhikevich mathematical model of biological neurons is carried out.
Comparing and Optimizing RNA Extraction from the Pancreas of Diabetic and Healthy Rats for Gene Expression Analyses

Advanced differential gene expression analysis requires high-quality RNA. However, isolating intact pancreatic RNA is challenging due to abundant pancreatic ribonucleases, which limits efficient downstream gene expression analysis. RNAlater treatment reduces endogenous ribonucleases effects through either pre-organ excision via organ mass or bile duct direct injection or organ mass injection post-isolation. We compared RNA extraction protocols to establish a reproducible and effective pancreatic RNA extraction method to obtain high RNA integrity number (RIN) values from healthy and streptozotocin (STZ)-induced diabetic rats for gene expression analyses. Different methods were tested focusing on RNase activity inhibition using RNAlater (Qiagen) pre-harvest of the pancreatic tissue, and extracted RNA quality and concentration were analyzed using NanoDrop spectrophotometer, Agilent Bioanalyzer, and RT-PCR. Inclusion of several pre- and post-excision modifications in the RNeasy Mini Kit (Qiagen) protocol resulted in RIN values more than two-fold higher compared to those using the standard protocol. Additionally, RT-PCR amplification of the housekeeping gene, β-actin, revealed no differences in extracted RNA quality from healthy and STZ-induced diabetic rats. We compared and developed a more effective and reproducible pancreatic RNA extraction method from healthy and diabetic rats, which resulted in RNA of superior quality and integrity and is suitable for complex molecular investigations.
Neuroimaging findings in immune effector cell associated neurotoxicity syndrome after chimeric antigen receptor T-cell therapy

Abstract Chimeric antigen receptor T-cell (CAR-T) therapy is a promising immunotherapy approved for hematological malignancies. Despite its effectiveness, clinically significant rates of toxicity, including immune effector cell associated neurotoxicity syndrome (ICANS), limit its widespread use. In certain contexts, ICANS may occur in up to one-third of patients using commercially available CAR-T therapies. The syndrome presents with a range of neurological signs and symptoms, as well as a variety of neuroimaging manifestations reported in the literature. A systematic review of the literature was performed. The systematic search strategy identified 24 studies discussing the neuroimaging appearances associated with ICANS. Imaging findings are more common in patients with higher grade neurotoxicity. The neuroimaging findings are heterogeneous, but can be grouped either anatomically (white matter, gray matter, brainstem, or leptomeninges) or pathologically (ischemic changes, hemorrhages, or cerebral edema). An understanding of the imaging manifestations of ICANS has the potential to impact the management of patients.
Room Monitoring Uses ESP-12E Based DHT22 and BH1750 Sensors

Comfortable room is one of the services that must be provided by STMIK STIKOM Indonesia campus to students. This research designed a room monitoring tool based on ESP-12E in STMIK STIKOM Indonesia. The room monitor is designed using a DHT22 sensor to measure temperature and humidity and the BH1750 sensor to measure light intensity. The tool also includes features a 16x2 I2C LCD to display measurement results. Testing is done by testing the layout circuit on the PCB and observing the measurement of temperature, humidity, and light intensity on the LCD. The test results of all layout circuits are functioning properly, and the measurement results can appear on the 16x2 I2C LCD.
Meaning in a World in Crisis: Perspectives of Societal Resilience and Growth: An Introduction to the Special Section of the Journal of Constructivist Psychology

The world is in crisis! While we are writing this introduction, the COVID-19 pandemic continues to hold many countries in its tight grip. Countries have gone into lock-down over the Omicron variant. People have lost their jobs. Above all, the current pandemic highlights the underlying long-term crises of racism and social inequality, whereas for example communities of color and individuals with lower socio-economic status are impacted disproportionally by the pandemic. The articles in this special issue reflect the new meaning of meaning. We discuss multidisciplinary perspectives on how meaning is experienced in different contexts and crises. Together, these articles show the personal and societal power of meaning, and stand for meaning in our globalized society. (PsycInfo Database Record (c) 2023 APA, all rights reserved)
Computational Study of the Phytochemical Constituents from Uncaria tomentosa Stem Bark against SARS-CoV-2 Omicron Spike Protein

The SARS-CoV-2 Omicron variant has spread rapidly and is considered the predominant variant in the world, and its main characteristic is related to evade immunity from natural infection or vaccines, due to its multiple mutations in the spike protein. On the other hand, medicinal plants have been used as alternatives therapies to ameliorate some signs and symptoms in COVID-19, and in our previous work, the cat’s claw (Uncaria tomentosa) stem bark has been studied in vitro and showed antiviral activity on SARS-CoV-2 as well as in silico studies on the 3CLpro protein and as disruptor between the ACE-2 human receptor and the spike protein. The aim in this computational study was to determine the main phytochemical constituents from U. tomentosa stem bark against the SARS-CoV-2 Omicron spike protein based on molecular modeling. A molecular docking was carried out on the isolated phytochemicals in a previous work against the SARS-CoV-2 Omicron spike protein-binding domain (PDB ID: 7T9K). Next, a molecular dynamic study was carried out to monitor the stability during the MD simulations. As results proanthocyanidin-C1 (-10.76 kcal/mol), quinovic acid-type 2 (-9.86 kcal/mol), and proanthocyanidin-B2 (-9.82 kcal/mol) were the constituents with the best binding free energy on the SARS-CoV-2 Omicron spike protein, and the best compound was stable during the dynamic simulation under physiological conditions. It is concluded that the anthocyanidin-based compounds determined in the stem bark ethanol extract could be responsible for the potential antiviral activity on SARS-CoV-2 Omicron variant, and the proanthocyanidin-C1 emerged as a powerful candidate to combat new variants.
Applying a Multiple Convergent Process in Achieving a Successful of New Product Developmen

New Product Development (NPD) is critical for companies to improve their business results. However, few companies can benefit from such a process because it is difficult to determine how and which NPD processes should be designed to develop a leading-edge product. The objective of this study is to find out the appropriate and best approach for implementing an NPD process in a company. The Multiple Convergent Process (MCP) framework model is applied by borrowing the framework model of (Baker & Hart, 2007). The objective of the MCP framework model is to apply a parallel mechanism of NPD phases to work towards the same point or common outcome without delaying the next phase. This study applies a descriptive research method by describing the steps of the MCP model and using literature reviews. Fifty-two publications from 1990 to 2018 were reviewed. Major and related topics such as NPD, innovation, multiple convergent points, idea generation - evaluation - concept and selection, and factors for successful NPD were considered.
Metagenomic Analysis of RNA Viruses in Watermelon

Watermelon is one of the most consumed cucurbits worldwide. Its production, nevertheless, is threatened by different pathogens that compromise the development of plants and, consequently, fruits. Here, plants showing typical virus-like symptoms were collected in the Tocantins State, Brazil. Aiming for the identification of viruses, viral RNA was sequenced by Illumina. Four virus genomes were sequenced and assembled, corresponding to isolates of Papaya ringspot virus (PRSV) and Zucchini Yellow Mosaic Virus (ZYMV) from the family Potyviridae, Groundnut ringspot virus (GRSV) from the family Bunyaviridae, and Citrullus lanatus partitivirus (CiLPV) from family Partitiviridae. Although these viruses have been previously reported infecting watermelon, we have sequenced the first complete genome of GRSV and the first complete genome of a ZYMV isolate from Brazil. Symptomatic watermelon leaves from the field were also used as inoculation for virus mechanical transmission to indicative plants. Despite co-infecting watermelon plants in the field, only the potyviruses were mechanically transmitted to indicative plants, in which ZYMV presented the broadest host range.
Survey on the Knowledge Base of EFL Pre-service Teachers for Phonics Instruction

Phonics which refers to the letter-sound relationship originates in English speaking countries. Phonics instruction is part of early reading instruction. Based on previous literatures, the most suitable one for EFL students is synthetic phonics instruction approach. Since 2011, phonics is required by National English Curriculum in China, literatures indicated that in the actual teaching activities, it is hard to implement phonics instruction, regardless of phonics instruction approaches. The rationale for this is that the in-service teachers and pre-service teachers are short of subject matter content knowledge. Very few studies are conducted to look into in-service EFL teachers and pre- service EFL teachers’ knowledge base to teach phonics. To bridge the gap, this study aims at providing preliminary descriptive data via a survey on pre- service EFL teachers’ knowledge base to teach phonics. To attain this goal, 104 pre-service EFL teachers ranging from the first academic year to the fourth academic year are selected via random sampling technique to fill in the survey. The findings indicate their weak knowledge base for phonics instructions. This study hopes to provide empirical information for policy makers or researchers to look into this matter to take some measures to prepare pre-service EFL teachers to teach phonics in order to promote the implementation of phonics instruction in EFL context in China.