Miracle-dz/UniFAR-FTUs huggingface dataset:
Thrombospondin 1 in Metabolic Diseases

The thrombospondin family comprises of five multifunctional glycoproteins, whose best-studied member is thrombospondin 1 (TSP1). This matricellular protein is a potent antiangiogenic agent that inhibits endothelial migration and proliferation, and induces endothelial apoptosis. Studies have demonstrated a regulatory role of TSP1 in cell migration and in activation of the latent transforming growth factor beta 1 (TGFβ1). These functions of TSP1 translate into its broad modulation of immune processes. Further, imbalances in immune regulation have been increasingly linked to pathological conditions such as obesity and diabetes mellitus. While most studies in the past have focused on the role of TSP1 in cancer and inflammation, recently published data have revealed new insights about the role of TSP1 in physiological and metabolic disorders. Here, we highlight recent findings that associate TSP1 and its receptors to obesity, diabetes, and cardiovascular diseases. TSP1 regulates nitric oxide, activates latent TGFβ1, and interacts with receptors CD36 and CD47, to play an important role in cell metabolism. Thus, TSP1 and its major receptors may be considered a potential therapeutic target for metabolic diseases.
Mid-Range Wireless Power Transfer System for Various Types of Multiple Receivers Using Power Customized Resonator

This paper presents a high-efficiency wireless power transfer (WPT) system that can charge multiple receivers (Rx’s) of various types. For system analysis, the transmitted power and received power levels are derived using the parameters of the resonators based on electro-magnetic (EM) resonance. Using the analysis results, the power customized resonator (PCR) not only for deriving sufficient output power from the transmitter (Tx) but also for appropriately distributing the received power to the various and multiple Rx’s is proposed. In addition to the PCR, the Tx unit is designed to work as a load-dependent voltage source using a differential Class-E power amplifier (PA) through a wide range of load impedances. Therefore, the Tx can naturally adapt to the required Tx power levels with a high efficiency corresponding to various Rx configurations without additional tunable circuits or adaptive control schemes. The WPT system, including the load-dependent voltage source for the Tx, full-bridge rectifiers for the Rx’s, and the proposed PCR, was designed for the 6.78 MHz frequency band. The proposed system is validated for use with multiple mobile devices by conducting experiments with nine charging cases using three types of Rx’s. For all cases, high system efficiencies of 70.7–85.5% were maintained over received power levels of 8.6–45.7 W at a charging distance of 30 mm, and each of the three types of Rx’s were experimentally verified to receive sufficient power.
Genetic Gains in Pearl Millet in India: Insights Into Historic Breeding Strategies and Future Perspective

Pearl millet (Pennisetum glaucum R. Br.) is an important staple and nutritious food crop in the semiarid and arid ecologies of South Asia (SA) and Sub-Saharan Africa (SSA). In view of climate change, depleting water resources, and widespread malnutrition, there is a need to accelerate the rate of genetic gains in pearl millet productivity. This review discusses past strategies and future approaches to accelerate genetic gains to meet future demand. Pearl millet breeding in India has historically evolved very comprehensively from open-pollinated varieties development to hybrid breeding. Availability of stable cytoplasmic male sterility system with adequate restorers and strategic use of genetic resources from India and SSA laid the strong foundation of hybrid breeding. Genetic and cytoplasmic diversification of hybrid parental lines, periodic replacement of hybrids, and breeding disease-resistant and stress-tolerant cultivars have been areas of very high priority. As a result, an annual yield increase of 4% has been realized in the last three decades. There is considerable scope to further accelerate the efforts on hybrid breeding for drought-prone areas in SA and SSA. Heterotic grouping of hybrid parental lines is essential to sustain long-term genetic gains. Time is now ripe for mainstreaming of the nutritional traits improvement in pearl millet breeding programs. New opportunities are emerging to improve the efficiency and precision of breeding. Development and application of high-throughput genomic tools, speed breeding, and precision phenotyping protocols need to be intensified to exploit a huge wealth of native genetic variation available in pearl millet to accelerate the genetic gains.
A Local and Low-Dose Chemotherapy/Autophagy-Enhancing Regimen Treatment Markedly Inhibited the Growth of Established Solid Tumors Through a Systemic Antitumor Immune Response

Chemotherapy is one of the main options for the treatment of a variety of malignant tumors. However, the severe side effects resulting from the killing of normal proliferating cells limit the application of cancer-targeting chemotherapeutic drugs. To improve the efficacy of classic systemic chemotherapy, the local delivery of high-dose chemotherapeutic drugs was developed as a method to enhance local drug concentrations and minimize systemic toxicity. Studies have demonstrated that chemotherapy is often accompanied by cancer-associated immunogenic cell death (ICD) and that autophagy is involved in the induction of ICD. To improve the efficacy of local cancer chemotherapy, we hypothesized that the local delivery of chemotherapeutic plus autophagy-enhancing agents would enhance the promotive effects of ICD on the antitumor immune response. Here, we report that a low-dose chemotherapy/autophagy enhancing regimen (CAER) not only resulted in the increased death of B16F10 and 4T1 tumor cells, but also induced higher levels of autophagy in vitro. Importantly, the local delivery of the CARE drugs significantly inhibited tumor growth in B16F10 and 4T1 tumor-bearing mice. Systemic antitumor T-cell immunity was observed in vivo, including neoantigen-specific T-cell responses. Furthermore, bioinformatic analysis of human breast cancer and melanoma tissues showed that autophagy-associated gene expression was upregulated in tumor samples. Increased autophagy and immune cell infiltration in tumor tissues were positively correlated with good prognosis of tumor patients. This work highlights a new approach to improve the effects of local chemotherapy and enhance systemic antitumor immunity.
Optimizing the Femoral Offset for Restoring Physiological Hip Muscle Function in Patients With Total Hip Arthroplasty

Objective Femoral offset (FO) restoration is significantly correlated with functional recovery following total hip arthroplasty (THA). Accurately assessing the effects of FO changes on hip muscles following THA would help improve function and optimize functional outcomes. The present study aimed to (1) identify the impact of FO side difference on the hip muscle moment arms following unilateral THA during gait and (2) propose the optimal FO for a physiological hip muscle function. Methods In vivo hip kinematics from eighteen unilateral THA patients during gait were measured with a dual-fluoroscopic imaging system. The moment arms of thirteen hip muscles were calculated using CT-based 3D musculoskeletal models with the hip muscles’ lines of actions. The correlation coefficient (R) between FO and hip muscle moment arm changes compared with the non-implanted hip was calculated. We considered that the FO reconstruction was satisfactory when the abductor moment arms increased, while the extensor, adductor, and flexor moment arms decreased less than 5%. Results A decreased FO following THA was significantly correlated with a decrease of the abductor and external rotator moment arms during the whole gait (R > 0.5) and a decrease of extensor moment arms during the stance phase (R > 0.4). An increased FO following THA was significantly associated with shorter flexor moment arms throughout the gait (R < −0.5) and shorter adductor moment arms in the stance phase (R < −0.4). An increase in FO of 2.3–2.9 mm resulted in increased abductor moment arms while maintaining the maximum decrease of the hip muscles at less than 5.0%. Conclusion An increase of 2–3 mm in FO could improve the abductor and external rotator function following a THA. Accurate surgical planning with optimal FO reconstruction is essential to restoring normal hip muscle function in THA patients.
Development of a method to lower recontamination after chemical decontamination by depositing Pt nano particles: (I) Consideration of the suppression mechanism using a quantum dynamics calculation

The Pt coating (Pt-C) process has been developed to lower the recontamination by radioactive elements after chemical decontamination of piping surfaces. In this process, a layer of fine Pt nano particles is formed in an aqueous solution on the base metal of the piping following the chemical decontamination. In this study, we confirmed that the suppression effect by the Pt-C toward 60Co deposition on type 316 stainless steel using a 60Co deposition test under hydrogen water chemistry. Furthermore, we investigated the suppression mechanism of deposition of radioactive elements by a quantum molecular simulation. The deposition amounts of 60Co which were incorporated in oxides after 1000 h with and without the Pt-C process were about 90 and 10.2 Bq/cm2, respectively. The amount of 60Co deposition with Pt-C is about 10% that of non-coated specimens. The 60Co incorporation for the Pt-C specimen was suppressed by decreasing the formation of oxides. We considered this phenomenon using a quantum dynamics calculation and concluded that the Fe–O bonds in oxides were weakened by the effect of Pt and hydrogen radicals which were produced in the reaction between H2 and Pt, and then oxides were dissolved into the water.
LTGH: A Dynamic Texture Feature for Working Condition Recognition in the Froth Flotation

Texture feature of the froth image is widely used in the working condition recognition of froth flotation. However, due to the complexity of the froth image, the current texture features vary greatly and are difficult to identify the work condition accurately. Therefore, we propose a dynamic texture feature named LBP on the TOP and GLCM Histograms (LTGH) which integrates the local binary patterns (LBPs) and gray-level co-occurrence matrix (GLCM) histograms on the three orthogonal planes (TOP). First, we use the rotation invariant LBPs to enhance rotation invariance and illumination robustness. Then, we implement the TOP on the enhanced texture feature map to generate the multiple dimensional enhanced feature maps. After that, we calculate the GLCM and supplementary features (SFs) on the multiple dimensional enhanced feature map. Finally, we integrate the histogram of the GLCM and SFs to discriminate the texture feature. The LTGH feature considers the froth structures both in the macrolevel and microlevel and captures the temporal information between the froth images. Experiments have demonstrated the effectiveness and stability of the proposed texture feature for work condition recognition in froth flotation. Compared with other traditional texture features, the accuracy of the LTGH feature has been increased by at least 7.76%.
The Lichens’ Microbiota, Still a Mystery?

Lichens represent self-supporting symbioses, which occur in a wide range of terrestrial habitats and which contribute significantly to mineral cycling and energy flow at a global scale. Lichens usually grow much slower than higher plants. Nevertheless, lichens can contribute substantially to biomass production. This review focuses on the lichen symbiosis in general and especially on the model species Lobaria pulmonaria L. Hoffm. , which is a large foliose lichen that occurs worldwide on tree trunks in undisturbed forests with long ecological continuity. In comparison to many other lichens, L. pulmonaria is less tolerant to desiccation and highly sensitive to air pollution. The name-giving mycobiont (belonging to the Ascomycota), provides a protective layer covering a layer of the green-algal photobiont (Dictyochloropsis reticulata) and interspersed cyanobacterial cell clusters (Nostoc spec.). Recently performed metaproteome analyses confirm the partition of functions in lichen partnerships. The ample functional diversity of the mycobiont contrasts the predominant function of the photobiont in production (and secretion) of energy-rich carbohydrates, and the cyanobiont’s contribution by nitrogen fixation. In addition, high throughput and state-of-the-art metagenomics and community fingerprinting, metatranscriptomics, and MS-based metaproteomics identify the bacterial community present on L. pulmonaria as a surprisingly abundant and structurally integrated element of the lichen symbiosis. Comparative metaproteome analyses of lichens from different sampling sites suggest the presence of a relatively stable core microbiome and a sampling site-specific portion of the microbiome. Moreover, these studies indicate how the microbiota may contribute to the symbiotic system, to improve its health, growth and fitness.
A Qualitative Exploration of Chinese Self-Love

Although self-love is an important topic, it has not been viewed as appropriate for psychological research, especially in China. We conducted two studies to understand how Chinese people view self-love. In the first study, we surveyed 109 Chinese people about the dimensions of self-love using an open-ended questionnaire. In the second study, 18 participants were selected by means of intensity sampling and interviewed about the connotations and structure of Chinese self-love. The two studies revealed three important aspects of the Chinese understanding of self-love: (1) self-love has four dimensions: self, family, others, and society; (2) it comprises five components: self-cherishing, self-acceptance, self-restraint, self-responsibility, and self-persistence; and (3) the five components of self-love are linked together to form a stable personality structure. The reliability and validity of the two studies were strong. Finally, the results showed that Chinese self-love is dominated by Confucian culture, which provides guiding principles for how to be human. At the same time, it shows that there are differences in the understanding of self-love between Chinese and Western cultures, which provides an empirical basis for further research based on cross-cultural psychology and self-love psychology.
Mild Cognitive Impairment in de novo Parkinson's Disease: Selective Attention Deficit as Early Sign of Neurocognitive Decay

Background: In the present study, we aimed to better investigate attention system profile of Parkinson's disease-Mild Cognitive Impairment (PD-MCI) patients and to determine if specific attentional deficits are associated with 123I-FP-CIT SPECT. Methods: A total of 44 de novo drug-naïve PD patients [(27) with normal cognition (PD-NC) and 17 with MCI (PD-MCI)], 23 MCI patients and 23 individuals with subjective cognitive impairment (SCI) were recruited at the Clinical Neurology Unit of Santa Chiara hospital (Pisa University Medical School, Italy). They were assessed by a wide neuropsychological battery, including Visual Search Test (VST) measuring selective attention. Performances among groups were compared by non-parametric tests (i.e., Kruskal-Wallis and Mann-Whitney, Bonferroni corrected). Further, Spearman's rank correlations were performed to explore the association between neuropsychological variables and 123I-FP-CIT SPECT data in PD subgroup. Results: PD-MCI patients performed worse on VST than patients with PD-NC (p = 0.002), patients with MCI and individuals with SCI (p < 0.001). The performance of PD-MCI patients on VST significantly correlated with caudate nucleus 123I-FP-CIT SPECT uptake (rho = 0.582, p < 0.05), whereas a negative correlation between such test and 123I-FP-CIT SPECT uptake in the left putamen (rho = −0.529, p < 0.05) was found in PD-NC patients. Conclusions: We suggest that selective attention deficit might be a trigger of cognitive decay in de novo PD-MCI patients. The VST should be routinely used to detect attentional deficits in hospital clinical practice, in the light of its closely association with dopamine depletion of basal ganglia in mildly impaired PD patients.
New Social Horizons: Anxiety, Isolation, and Animal Crossing During the COVID-19 Pandemic

Increased participation in activities has been associated with improved positive mental health outcomes. However, there is much debate regarding the net effects of video games on individuals. Typified as a socially isolating activity, many games inherently contain socialization within the environment with game-generated characters or other players. Coinciding with the time of the initial pandemic/quarantine period was the release of a popular socializing and life simulation game, Animal Crossing: New Horizons. We investigated whether participation in this game was related to emotional outcomes associated with pandemics (e.g., loneliness and anxiety). The relationship between deleterious mental health and social gaming, amid a time of enforced reduction in socializing, would allow us to isolate the impact of the introduction of a social video game on improving the quality of life for players of this game. Participants (n = 1053) were asked about their time spent playing video games via an online survey, their socialization in game play, loneliness, and anxiety. We predicted that participants with higher levels of social interaction within the game would report less loneliness and anxiety. Utilizing multiple linear regression analyses, the research found that increased gaming and related activities were predictive of higher anxiety and somewhat related to increased loneliness. However, increased visits to another island were associated with lower levels of loneliness. As such, players may be utilizing gaming as a coping mechanism for anxiety. This research may inform generalized research regarding the influence that social games may have on feelings of loneliness and anxiety.
Flower Pollination Algorithm For Reactive Power Dispatch Using Unified Power Flow Controller

One of the most important tasks needed for proper operation and control of a power system is reactive power or Volt Ampere Reactance (VAR). By changing the reactive power control variables by Generator Voltages, Transformers tap settings and other reactive power sources such as Capacitor Banks and FACTS Units, reactive power management is carried out to minimize the losses in a power system. Reactive power VAR control offers improved power transfer capacity and overall device activity for system security enhancement. VAR is a complex problem of combinational optimization which involves non-linear functions with several local minimum and non-linear and discontinuous constraints.In order to minimize real power losses, the VAR or reactive power problem is formulated as a non-linear restricted optimization problem with equality and inequality constraints. The problem is solved using the Algorithm for Flower Pollination. The flower pollination algorithm is a new algorithm inspired by nature, which is a population based on flowering plant characteristics.In this paper, we extend this flower algorithm to solve problems in engineering for reactive power optimization. The Truth devices known as the Unified Power Flow Controller are used to mitigate actual power losses. This UPFC is a mixture of SVC and TCSC that is used in the system as a shunt and series controller. The testing system used here is the IEEE 57 Bus Test System.
Assessment of Impacts on Integration of Disorderly EV Charging Load to Flexible Distribution Network

The use of power electronics technology to transform the distribution network, realize multi-terminal flexible closed-loop operation and greatly improve the power supply capacity is an important form of future development of the distribution network. At the same time, along with the large-scale promotion of electric vehicles (EVs), the disorderly access of charging load is bound to bring challenges to the safe and stable operation of the distribution network. Therefore, it is necessary to evaluate and analyse the impact of EV charging load access in the flexible distribution network. Firstly, this paper constructs operational constraints based on the operating characteristics of the flexible distribution network; secondly, based on the disorderly access characteristics of EVs, the EV charging load model is constructed through a multi-factor combination; finally, tests are carried out in the IEEE 33 interconnection system. The results show that the flexible interconnection can effectively optimize the distribution of tides over time and suppress the voltage deviation.
Antenna Designs for CubeSats: A Review

Cube Satellites, aka CubeSats, are a class of nano satellites that have gained popularity recently, especially for those that consider CubeSats as an emerging alternative to conventional satellites for space programs. This is because they are cost-effective, and they can be built using commercial off-the-shelf components. Moreover, CubeSats can communicate with each other in space and ground stations to carry out many functions such as remote sensing (e.g., land imaging, education), space research, wide area measurements and deep space communications. Consequently, communications between CubeSats and ground stations is critical. Any antenna design for a CubeSat needs to meet size and weight restrictions while yielding good antenna radiation performance. To date, a limited number of works have surveyed, compared and categorised the proposed antenna designs for CubeSats based on their operating frequency bands. To this end, this paper contributes to the literature by focusing on different antenna types with different operating frequency bands that are proposed for CubeSat applications. This paper reviews 48 antenna designs, which include 18 patch antennas, 5 slot antennas, 4 dipole and monopole antennas, 3 reflector antennas, 3 reflectarray antennas, 5 helical antennas, 2 metasurface antennas and 3 millimeter and sub-millimeter wave antennas. The current CubeSat antenna design challenges and design techniques to address these challenges are discussed. In addition, we classify these antennas according to their operating frequency bands, e.g., VHF, UHF, L, S, C, X, Ku, K/Ka, W and mm/sub-mm wave bands and provide an extensive qualitative comparison in terms of their size, −10 dB bandwidths, gains, reflection coefficients, and deployability. The suitability of different antenna types for different applications as well as the future trends for CubeSat antennas are also presented.
Functional Selectivity Does Not Predict Antinociceptive/Locomotor Impairing Potencies of NOP Receptor Agonists

Nociceptin/orphanin FQ controls several functions, including pain transmission, via stimulation of the N/OFQ peptide (NOP) receptor. Here we tested the hypothesis that NOP biased agonism may be instrumental for identifying innovative analgesics. In vitro experiments were performed with the dynamic mass redistribution label free assay and the NOP non-peptide agonists Ro 65-6570, AT-403 and MCOPPB. In vivo studies were performed in wild type and β-arrestin 2 knockout mice using the formalin, rotarod and locomotor activity tests. In vitro all compounds mimicked the effects of N/OFQ behaving as potent NOP full agonists. In vivo Ro 65-6570 demonstrated a slightly higher therapeutic index (antinociceptive vs. motor impairment effects) in knockout mice. However, all NOP agonists displayed very similar therapeutic index in normal mice despite significant differences in G protein biased agonism. In conclusion the different ability of inducing G protein vs. β-arrestin 2 recruitment of a NOP agonist cannot be applied to predict its antinociceptive vs. motor impairment properties.