Miracle-dz/UniFAR-FTUs huggingface dataset:
Mammary Analogue Secretory Carcinoma of Salivary Glands With High-grade Transformation: Report of 3 Cases With the ETV6-NTRK3 Gene Fusion and Analysis of TP53, &bgr;-Catenin, EGFR, and CCND1 Genes

Mammary analogue secretory carcinoma of salivary gland origin (MASC) is a recently described tumor resembling secretory carcinoma of the breast characterized by strong S-100 protein, mammaglobin, and vimentin immunoexpression and which harbors a t(12;15) (p13;q25) translocation resulting in ETV6-NTRK3 fusion product. Histologically, conventional MASC displays bland histomorphology and a lobulated growth pattern and is often composed of microcystic, tubular, and solid structures with abundant eosinophilic homogenous or bubbly secretions. Colloid-like secretory material stains positively for periodic acid-Schiff with and without diastase as well as for Alcian Blue. We present for the first time, 3 patients with MASC of the parotid gland in which high-grade (HG) transformation developed in each case characterized by an accelerated clinical course and poor outcome. The HG component revealed strong membrane staining for EGFR and &bgr;-catenin, cytoplasmic/nuclear staining for S-100 protein, and nuclear staining for cyclin-D1, whereas HER-2/neu was absent. Analysis for the presence of the ETV6-NTRK3 fusion transcript revealed positivity in both HG and low-grade component of MASC in 2 of the 3 studied cases. The tumor in case 2 was negative in both its elements for the t(12;15) translocation, but ETV6 gene rearrangement was detected in both components in all 3 cases. Analysis of TP53 and CTNNB1 gene mutations in the HG component of MASCs as well as detection of copy number aberration of EGFR and CCND1 gene did not harbor any abnormalities. All 3 patients with HG-transformed MASC died of disseminated disease within 2 to 6 years after diagnosis. Recognizing HG-transformed MASC and testing for ETV6 rearrangement may be of potential value in patient treatment, because the presence of the ETV6-NTRK3 translocation may represent a therapeutic target in MASC.
Modern solutions for industrial matrix-converter applications

Thus far, matrix converter topology has not reached industrial use. Reasons for this have been complex control schemes, inefficient solutions for overvoltage protection, questionable robustness of the bi-directional switch commutation at disturbed supply voltages, and missing power semiconductor modules. Recent research results concerning these problems have led to innovative solutions and, from a technical point of view, industrial use seems to be reasonable now.
Electromagnetic detection of dielectric cylinders by a neural network approach

The neural network approach is applied to the detection of cylindric objects as well as their geometric and electrical characteristics inside a given investigation domain. The electric field values scattered by the object and available at a small number of locations are fed into the network, whose output is the dielectric permittivity, and the location and radius of the cylinder. The results are evaluated using different sets of testing data, and the dependence of the various output parameters to the input are considered. The algorithm performance shows that the approach is able to solve the inverse scattering problem quickly. This may be useful for real-time remote-sensing applications.
Effect of chronic undernutrition in the rat on the development of myelin

IT IS NOW established from biochemical (DOBBING, 1964; BENTON et a[., 1966; CULLEY et al., 1966; CHASE et al., 1967; DICKERSON et al., 1967; Rosso et al., 1970) and histological (BENTON er al., 1966; FISHMAN et al., 1969; STEWART et a/., 1974) studies that malnutrition during development retards the quantitative deposition of myelin in the central nervous system (CNS). However, controversy exists as to the qualitative nature (e.g. maturity) of the myelin of undernourished animals, for whilst FISHMAN et al. (1971) found no change from the normal pattern in the lipid composition of brain myelin of undernourished rats, the morphometric studies by KRICMAN & HOGAN (1976) and the protein pattern studies by WIGGINS et al. (1976) in the same species indicated a maturational lag in the myelin lamellae during undernutrition. The high preponderance of cholesterol esters in the brain of malnourished mice (YUSUF & MOZAFFAR, 1979) and children (YUSUF, 1976) has also been interpreted as indicating immaturity of myelin. This paper reports a study of the effects of chronic undernutrition on myelin development, using the characteristic ganglioside pattern of the membrane as an index of maturation.
Increased Femoral Anteversion Does Not Lead to Increased Joint Forces During Gait in a Cohort of Adolescent Patients

Orthopedic complications were previously reported for patients with increased femoral anteversion. A more comprehensive analysis of the influence of increased femoral anteversion on joint loading in these patients is required to better understand the pathology and its clinical management. Therefore, the aim was to investigate lower-limb kinematics, joint moments and forces during gait in adolescent patients with increased, isolated femoral anteversion compared to typically developing controls. Secondly, relationships between the joint loads experienced by the patients and different morphological and kinematic features were investigated. Patients with increased femoral anteversion (n = 42, 12.8 ± 1.9 years, femoral anteversion: 39.6 ± 6.9°) were compared to typically developing controls (n = 9, 12.0 ± 3.0 years, femoral anteversion: 18.7 ± 4.1°). Hip and knee joint kinematics and kinetics were calculated using subject-specific musculoskeletal models. Differences between patients and controls in the investigated outcome variables (joint kinematics, moments, and forces) were evaluated through statistical parametric mapping with Hotelling T2 and t-tests (α = 0.05). Canonical correlation analyses (CCAs) and regression analyses were used to evaluate within the patients’ cohort the effect of different morphological and kinematic predictors on the outcome variables. Predicted compressive proximo-distal loads in both hip and knee joints were significantly reduced in patients compared to controls. A gait pattern characterized by increased knee flexion during terminal stance (KneeFlex tSt ) was significantly correlated with hip and knee forces, as well as with the resultant force exerted by the quadriceps on the patella. On the other hand, hip internal rotation and in-toeing, did not affect the loads in the joints. Based on the finding of the CCAs and linear regression analyses, patients were further divided into two subgroups based KneeFlex tSt . Patients with excessive KneeFlex tSt presented a significantly higher femoral anteversion than those with normal KneeFlex tSt . Patients with excessive KneeFlex tSt presented significantly larger quadriceps forces on the patella and a larger posteriorly-oriented shear force at the knee, compared to patients with normal KneeFlex tSt , but both patients’ subgroups presented only limited differences in terms of joint loading compared to controls. This study showed that an altered femoral morphology does not necessarily lead to an increased risk of joint overloading, but instead patient-specific kinematics should be considered.
Modeling-based design of brain-inspired spiking neural networks with RRAM learning synapses

Brain-inspired computing is currently gaining momentum as a viable technology for artificial intelligence enabling recognition, language processing and online unsupervised learning. Brain-inspired circuit design is currently hindered by 2 fundamental limits: (i) understanding the event-driven spike processing in the human brain, and (ii) developing predictive models to design and optimize cognitive circuits. Here we present a comprehensive model for spiking neural networks based on spike-timing dependent plasticity (STDP) in resistive switching memory (RRAM) synapses. Both a Monte Carlo (MC) model and an analytical model are presented to describe experimental data from a state-of-the-art neuromorphic hardware. The model can predict the learning efficiency and time as a function of the input noise and pattern size, thus paving the way for model-based design of cognitive brain-like circuits.
Molecular cloning and sequences of lignin peroxidase genes of Phanerochaete chrysosporium

The genomic clones encoding lignin peroxidase isozyme H8 and two closely related genes were isolated from Phanerochaete chrysosporium BKM-1767, and their nucleotide sequences were determined. The positions and approximate lengths of introns were found to be highly conserved in all three clones. Analysis of homokaryotic derivatives indicated that the three clones are not alleles of the same gene(s).
Defensive efficacy interim design: Dynamic benefit/risk ratio view using probability of success

ABSTRACT Traditional efficacy interim design is based on alpha spending which does not have intuitive interpretation and hence is difficult to communicate with non-statistician colleagues. The alpha-spending approach is based on efficacy alone and hence does not have the flexibility to incorporate newly emerged safety signal. Newly emerged safety signal may nullify the originally set efficacy boundary. In contrast, the probability of success (POS) concept has intuitive interpretation and hence can facilitate our communication with non-statistician colleagues and help to obtain health authority (HA) buying. The success criteria of POS are not restricted to statistical significance. Hence, POS has the capability to incorporate both efficacy and safety information. We propose to use POS and its credible interval to design efficacy interim. In the proposed method, the efficacy boundary is adjustable to offset newly emerged safety signal.
Innate Immune Responses and P. falciparum CS Repeat-Specific Neutralizing Antibodies Following Vaccination by Skin Scarification

The skin is the site of host invasion by the mosquito-borne Plasmodium parasite, which caused an estimated 229 million infections and 409,000 deaths in 2019 according to WHO World Malaria report 2020. In our previous studies, we have shown that skin scarification (SS) with a P. falciparum circumsporozoite (CS) peptide in the oil-in-water adjuvant AddaVax containing a combination of TLR 7/8 and TLR 9 agonists can elicit sporozoite neutralizing antibodies. SS with AddaVax + TLR agonists, but not AddaVax alone, elicited CD4+ Th1 cells and IgG2a/c anti-repeat antibody. To explore the innate immune responses that may contribute to development of adaptive immunity following SS, we examined the skin at 4h and 24h post priming with CS peptide in AddaVax with or without TLR agonists. H&E stained and IHC-labeled dorsal skin sections obtained 24h post SS demonstrated a marked difference in the pattern of infiltration with F4/80+, CD11b+ and Ly6G+ cells at the immunization site, with the lowest intensity noted following SS with AddaVax + TLR agonists. Serum collected at 4h post SS, had reproducible increases in IL-6, MIP-3α, IL-22 and IP-10 (CXCL10) following SS with AddaVax + TLR agonists, but not with AddaVax alone. To begin to decipher the complex roles of these pro-inflammatory cytokines/chemokines, we utilized IP-10 deficient (IP-10 -/-) mice to examine the role of this chemokine in the development of anti-repeat antibody response following SS. In the absence of IP-10, the levels of Th1-type IgG2a/c antibody and kinetics of the primary anti-repeat antibody response were reduced following prime and boost. The IP-10 chemokine, present as early as 4h post prime, may provide an early serological marker for rapid screening of adjuvant formulations and delivery platforms to optimize SS-induced humoral immunity to CS repeats as well as other pathogens.
Bit-error-rate performance of lightwave hybrid AM/OFDM systems with comparison with AM/QAM systems in the presence of clipping impulse noise

Theoretical analysis is presented for the BER performance of hybrid AM/OFDM systems in the presence of clipping impulse and Gaussian noise. In particular, the OFDM BER has been compared with that of conventional QAM. It is found that, due to the dilution effect of the subchannels, the impact of the clipping impulse noise on BER for OFDM systems is virtually zero for reasonably large laser modulation depths. Therefore, OFDM is more suitable to the lightwave transmission of digital video.
Proposed obesity body mass index correction for self-reported data may not be appropriate

The study published by Dauphinot et al 1 in the February issue of the Journal of Epidemiology and Community Health compared self-reported and measured body mass index (BMI) in a sample of the general population of Geneva (Switzerland) and a smaller French sample. In order to account for underestimation of BMI arising from self-reports, the authors proposed a universal cut-off of 29.2 kg/m2 instead of 30 kg/m2 for the definition of obesity. In a previous study, we compared the obesity prevalence based …
Principal features of contour beam phased array antennas

Herein, features of contour beams formed by phased array antennas are considered and main parameters of contoured beam phased arrays are reviewed. The key characteristic of contoured beam quality is the coverage efficiency, which is directly associated with the gain-area product. Contour beams formed by phase-only and amplitude-and-phase optimizations for service areas of different shapes are compared. Behaviors of the beams are interpreted in terms of the geometrical theory of diffraction. Examples of sidelobes suppression are demonstrated. Engineering formulas are proposed for estimation of the parameters of contoured beam array antennas. The features of contour beams scanning are described.
Chemical Process Performance Evaluation

Chapter 11 provides techniques for warranty analysis including data mining, reliability estimation from warranty claim data, warranty repair modeling, field failure monitoring, and warranty cost reduction. Chapters of this book are arranged according to the order of the product life cycle stages. Some of the techniques and methodologies described in each chapter may well serve in more than one product life cycle stage. For instance, the techniques described in Chapters 7 and 8 on accelerated life tests and degradation tests are useful in design and verification as well as testing stages. The author has done a great job in explaining the practical and state-ofthe-art techniques to access and enhance reliability throughout the product life cycle. This book deliberates on a wide range of topics in reliability engineering. Practical examples and exercises, mostly from the automotive industry, are used to illustrate the ideas and methodologies. Readers of this book are expected to have some knowledge of basic statistical inference, statistical modeling, and probability theory. This book will be of practical use for a variety of engineers, including reliability engineers, quality engineers, test engineers, systems engineers, or design engineers, who are working in different stages of the product life cycle. It will also serve well as a textbook or a reference book to students in a course on reliability, quality, or industrial engineering.
Genetic evaluation for large data sets by random regression models in Nellore cattle

Expected progeny differences (EPD) of Nellore cattle estimated by random regression model (RRM) and multiple trait model (MTM) were compared. Genetic evaluation data included 3,819,895 records of up nine sequential weights of 963,227 animals measured at ages ranging from one day (birth weight) to 733 days. Traits considered were weights at birth, ten to 110-day old, 102 to 202-day old, 193 to 293-day old, 283 to 383-day old, 376 to 476-day old, 551 to 651-day old, and 633 to 733-day old. Seven data samples were created. Because the parameters estimates biologically were better, two of them were chosen: one with 84,426 records and another with 72,040. Records preadjusted to a fixed age were analyzed by a MTM, which included the effects of contemporary group, age of dam class, additive direct, additive maternal, and maternal permanent environment. Analyses were carried out by REML, with five traits at a time. The RRM included the effects of age of animal, contemporary group, age of dam class, additive direct, permanent environment, additive maternal, and maternal permanent environment. Different degree of Legendre polynomials were used to describe random effects. MTM estimated covariance components and genetic parameters for weight at birth and sequential weights and RRM for all ages. Due to the fact that correlation among the estimates EPD from MTM and all the tested RM were not equal to 1.0, it is not possible to recommend RRM to genetic evaluation to large data sets.
Animal models of complex diseases: An initial strategy

We speculated that the rise in atmospheric oxygen from 2 billion years ago was so integral for the evolution of biocomplexity that it must also associate strongly with complex diseases. As a remote test of this idea, we hypothesized that lines contrasting for disease and health would emerge from artificial selection for low and high aerobic treadmill running capacity. Eleven generations of selection in rats produced lines that differed by 347% in running capacity. The low line demonstrated health risk factors including higher visceral adiposity, blood pressure, insulin, and triglycerides. The high line was superior for VO2max, economy of running, heart function, and nitric oxide‐induced vascular dilation. IUBMB Life, 57: 631‐638, 2005
Knowledge creation and the concept of a human being: A phenomenological approach

This study explores the effect of interaction in research on knowledge creation (KC) and its dependence on the conceptualization of a human being. A framework for understanding KC with hermeneutic phenomenology is developed, based on an analysis of recent KC research and key texts on hermeneutic phenomenology. The results obtained indicate that recent KC research still emphasizes the concept of knowledge as an asset inside the human mind, although the interest is in knowing and interpersonal relationships in working communities. Exploration of the use of the effect of interaction in research on KC shows that successful interaction is connected to the ideas of openness, critical thinking, and awareness of past experiences. These elements reflect the general ideas of the hermeneutic tradition without taking into account the historical roots of hermeneutics or questioning the concept of a human being behind them. It is concluded that the hermeneutic circle and phenomenological conceptualization of a human being provide a better defined and more coherent structure for understanding the event of KC as a future‐oriented, conscious act of interaction. The framework developed offers three fundamental areas for exploration: structure of the interactive event, construction of the human experience in interaction, and modes of being in interaction.
Spousal Intrusion as a Predictor of Wives' Marital Satisfaction in Their Spouses' Retirement

Retirement of men changes their roles and participation and affects their spouses' daily routines, roles, and participation. This study assessed the effects of spousal intrusion on marital satisfaction in retirement. Questionnaires assessing demographics, spousal intrusion, shared couple activities, feelings, and marital satisfaction were administered to a group of 151 volunteer women whose husbands were retired in two cities in Turkey. The women were recruited among those who were willing to share their feelings and thoughts about their husbands' retirement process as a result of one-on-one interviews. Hierarchical regression analysis indicated that the perception of spousal intrusion, education status, frequency of shared activities, and dyadic adjustment predicted women's marital satisfaction in retirement. However, spousal intrusion did not significantly predict women's marital satisfaction when dyadic adjustment was entered in the second model. In the third model, final variables together predicted 19% of women's marital satisfaction in their spouse's retirement. These findings are important as they underline the factors affecting women's marital satisfaction in their spouses' retirement period.
High speed VLSI architecture design for block turbo decoder

In this paper, a sub-optimal algorithm for decoding BCH (t /spl ges/ 2) turbo codes is presented. A high speed VLSI decoder architecture is proposed for codes constructed over extended GF(2/sup 5/). While the algorithm applies to higher order BCH product codes, it is shown that this particular block turbo codes, when decoded using the proposed algorithm, gives the best performance (achieving 10/sup -6/ bit error rate at a signal to noise ratio of 2.4 dB) among all two dimensional turbo product codes. Following an analysis of the impact of finite word-length effect on the performance of the SISO decoder, full parallel decoding architecture at the top level and a number of lower level high speed implementation strategies such as applying lookahead technique to reduce the critical path of the merge sort circuit and fast finite field operations are presented. Area and timing estimates obtained by logic synthesis (0.18 /spl mu/m, 1.5V CMOS technology) from VHDL descriptions are given to show how the design strategies translate into the area consumption and decoding throughput (> 32 Mbits/s.) of the VLSI implementation.
Suitable use of FRET-based Biosensors for Quantitative Detection of GPCR Activation

Cyclic adenosine 3’,5’-monophosphate is an important second messenger molecule that regulates many downstream signaling pathways in cells. Detection of cAMP levels relies on screenings of cell lysates or the use of genetically encoded biosensors for detection in living cells. Genetically encoded biosensors are, however, primarily used for bioimaging and rarely in high-throughput screenings of potential drug candidates. Here, we describe a quantitative fluorescence-based imaging method based on measurements of single living cells. We used a genetically encoded Epac149 biosensor to investigate cAMP production in living cells following ligand stimulation. The study revealed a dependence of the measured cAMP levels on the expression level of the biosensor in transiently transfected cells. While the biosensor maintained linearity of the signal at high expression levels, the linearity of the biosensor was lost at lower expression levels due to a deficit of the biosensor compared to the maximum possible production of cAMP in the cells. This problem was circumvented by establishment of a stable cell line with constitutive expression of the biosensor. We established dose response curves by stimulation with the β1-adrenergic receptor partial agonist denopamine and observed up to 1.48-fold difference in the cellular response as well as up to 4.27-fold difference in LogEC50 values between cells with insufficient and sufficient biosensor expression. Careful characterization and control of the biosensor expression is therefore important in order to conduct quantitative analysis of the cAMP production and it allows the use of genetically encoded biosensor to be applied in high-throughput screenings.