Miracle-dz/UniFAR-FTUs huggingface dataset:
Early Infection Immunity B and T Lymphocyte Attenuator Tempers

Coinhibitory pathways are thought to act in later stages of an adaptive immune response, but whether coinhibition contributes to early innate immunity is unclear. We show that engagement of the newly discovered coinhibitory receptor B and T lymphocyte attenuator (BTLA) by herpesvirus entry mediator (HVEM) is critical for negatively regulating early host immunity against intracellular bacteria. Both HVEM (cid:1) / (cid:1) and BTLA (cid:1) / (cid:1) , but not LIGHT (cid:1) / (cid:1) , mice are more resistant to listeriosis compared with wild-type mice, and blockade of the BTLA pathway promotes, while engagement inhibits, early bacterial clearance. Differences in bacterial clearance were seen as early as 1 day postinfection, implicating the initial innate response. Therefore, innate cell function in BTLA (cid:1) / (cid:1) mice was studied. We show that innate cells from BTLA (cid:1) / (cid:1) mice secrete signiﬁcantly more proinﬂammatory cytokines upon stimulation with heat-killed Listeria . These results provide the ﬁrst evidence that a coinhibitory pathway plays a critical role in regulating early host innate immunity against infection. The Journal of Immunology, 2009, 183: 0000–0000.
Efficient Pipelining Exploration for A High-performance CRYSTALS-Kyber Accelerator

This work presents the fastest and the most area-time efficient design reported till date for an FPGA based hardware accelerator designed for the CRYSTALS-Kyber lattice based Key Encapsulation Mechanism (KEM) scheme. Kyber was recently chosen as the first quantum resistant KEM scheme for standardisation, after three rounds of the National Institute of Standards and Technology (NIST) PQC initiation which commenced in 2016. Kyber is based on the Module-Learning with Errors (M-LWE) class of Lattice-based cryptography, which is known to manifest efficiently on FPGAs. The design methodology revolves around aggressively enabling maximum inter-module and intra module architectural parallelisation. To facilitate maximum throughput, FIFO-based buffering is provided and balanced to act as inter/intra-module pipelining. Area-time efficiency is high by effective resource reuse in case of NTT/INTT. A single NTT/INTT is computed in 128 cycles, once the pipeline is full. The FPGA based implementation results show that compared to the state-of-the-art, the proposed architecture delivers 24-52% speedups at three different security levels on Artix-7 and Zynq UltraScale+ devices, 50-75% reduction in DSPs and no BRAM resources usage for comparable security levels. Consequently, the AT product efficiency is reported to be 48-54% higher in comparison with the state-of-the-art designs. Hardware accelerator.
Finite Element Analysis Model-Based Cautious Automatic Optimal Shape Control for Fuselage Assembly

In a half fuselage assembly process, shape control is vital for achieving ultra-high-precision assembly. To achieve better shape adjustment, we need to determine the optimal location and force of each actuator to push or pull a fuselage to compensate for its initial shape dis- tortion. The current practice achieves this goal by solving a surrogate model-based optimization problem. However, there are two limitations of this surrogate model-based method: (1) low ef ﬁ ciency: collecting training data for surrogate modeling from many ﬁ nite element analysis (FEA) replications is time-consuming; (2) non-optimality: The required number of FEA replications for building an accurate surrogate model will increase as the potential number of actuator locations increases. Therefore, the surrogate model can only be built on a limited number of prespeci ﬁ ed potential actuator locations, which will lead to subop-timal control results. To address these issues, this paper proposes an FEA model-based automatic optimal shape control (AOSC) framework. This method directly loads the system equation from the FEA simulation platform to determine the optimal location and force of each actuator. Moreover, the proposed method further integrates the cautious control concept into the AOSC system to address model uncertainties in practice. The case study with industrial settings shows that the proposed Cautious AOSC method achieves higher control accuracy compared to the current industrial practice.
Simulating Future Crisis Scenarios with Multi-Agent Systems

In order to reduce the impact of bad situations as well as getting the most of profiting periods, it is vital to research in the field of methods, techniques and tools that allow us to simulate and foresee the future. Although this problem is common to any area, an urgent solution is required to those with critical social repercussions. Fields like national security, demography or economy are examples of areas in which prospective techniques are applicable. Technical prediction, with procedures like Prediction or Projection, is very common but in most cases not very efficient. It is not usual to find a critical social system which evolves according to predictable guidelines. For instance, the collapse of transports, economic crisis, natural disasters or terrorist attacks are examples of scenarios of crisis difficult to estimate with techniques of Prediction and Projection. This paper presents a solution to model human expert’s opinion with the aim of simulating possible future scenarios. Our approach consists of obtaining an applicable technology which enables us to be aware of possible crisis scenarios before they actually materialize, allowing us to analyse them and come up with appropriate risk mitigation strategies. This paper includes the description of a specific methodology to elaborate the opinion of human experts by using fuzzy logic and the development of multi-agent systems (MAS) to automate the creation of such scenarios. The method and tools are being validated with a real case study by the Spanish Institute for Strategic Studies (Ministry of
THE INFLUENCE OF WEBSITE QUALITY ON TRUST AND IMPACT ON PURCHASE INTENTION

This research to investigated the influence of website quality on trust and impact on purchase intention. Object of study in this research is website in Indonesia. Surveys were conducted to collect data from 330 respondents have visited the website. Analysis of data using Structural Equation Modeling with Smart PLS 3.0 software. The results of the direct hypothesis test that the variables Usefulness, Ease of Use, Entertainment and Complimentary Relationship have a significant effect on Trust. Variable Entertainment, Complimentary Relationship and Trust have a significant effect on Purchase intention. While the Usefulness and Ease of Use variables have no significant effect on Purchase intention. For the results of indirect hypothesis testing shows that the variables Usefulness, Ease of Use, Entertainment and Complimentary Relationship have a significant effect on purchase intention through trust as an intervening variable. Finally, the implications, limitations and recommendations for further research are discussed.
Mental Health Among Health Sciences Students in India During COVID-19: A Cross Sectional Study

Background and Aim: The pandemic has shown ill-effects on the physical mental health of the general public. Students of Health Sciences streams in India are no exception, as they face challenges that can be stressful and overwhelming. The aim of the study is to assess the pervasiveness of depression, anxiety, and stress among the health sciences conducted in among the of a in Results: total, 50.8% 509) experienced and 40.4% (n, 405) and 57.0% (n, 571) the and Among 1002, 63.6% (n, 637) 86.4% (n, 86.6) will be more responsive if such an event recurs, 91.0% (n, 912) will resort to healthy coping mechanisms, 86.3% (n, 865) are willing to volunteer in future pandemics, and 85.8% (n, 860) consider themselves prepared enough to withstand the negative impact of it if a similar situation recurs. Conclusion: These observations suggest that universities and government should promote awareness regarding psychological help among the students and encourage mental health screening programs to combat the adverse psychological effects. Approvals:
Early Detection of Diabetic Retinopathy Cases using Pre-trained EfficientNet and XGBoost

Diabetic retinopathy (DR) has been a leading cause of global blindness and its diagnosis through color fundus images requires experienced clinicians which makes this a difficult and time-consuming task. In this paper, a CNN approach is proposed to diagnose DR from digital color fundus images and create a preliminary system as an early detection of DR. Gaussian filter is applied to the images for filtering and resizing purpose before the images are processed any further. Furthermore, EfficientNet and XGBoost are used to extract the images’ features and classify the images correspondingly. The network is trained using a high-end GPU on the publicly available Asia Pacific Tele-Ophthalmology Society (APTOS) dataset. On the data set of 3662 Gaussian filtered and resized images used, the proposed model achieves an accuracy score of 98% for binary classification .
THE INFLUENCE OF PRODUCT QUALITY, BRAND IMAGE, BRAND TRUST ON CUSTOMER SATISFACTION AND LOYALTY

: This study aims to examine and explain the effect of product quality, brand image, brand trust on customer satisfaction, and loyalty of Samsung brand smartphones in Denpasar. The number of respondents in this study was 185 respondents, all respondents are people who live in Denpasar City who has ever purchased and used a Samsung smartphone. The sampling technique in this study was purposive sampling. The data from filling out the questionnaire were then analyzed using path analysis techniques using SEM (Structural Equation Modeling) with the help of the AMOS program. Based on the analysis in this study obtained some conclusions that product quality has a positive and significant effect on brand image, brand trust and customer satisfaction, brand image and brand trust has a positive and significant effect on satisfaction. Satisfaction has a positive and significant effect on customer loyalty. The implications of the results of this study indicate that product quality is found to be the main factor in increasing customer satisfaction so that it leads to a sense of customer loyalty. This shows that the better the product quality, the higher the loyalty of customers to buy and use Samsung brand smartphones in Denpasar City. show
Pancreatic Ductal Adenocarcinoma Radiology Reporting Template: Consensus Statement of the Society of Abdominal Radiology and the American Pancreatic Association 1

Pancreatic ductal adenocarcinoma is an aggressive malignancy with a high mortality rate. Proper determination of the extent of disease on imaging studies at the time of staging is one of the most important steps in optimal patient management. Given the variability in expertise and deﬁnition of disease extent among different practitioners as well as frequent lack of complete reporting of pertinent imaging ﬁndings at radiologic examinations, adoption of a standardized template for radiology reporting, using universally accepted and agreed on terminology for solid pancreatic neoplasms, is needed. A consensus statement describing a standardized reporting template authored by a multi-institutional group of experts in pancreatic ductal adenocarcinoma that included radiologists, gastro-enterologists, and hepatopancreatobiliary surgeons was developed under the joint sponsorship of the Society of Abdominal Radiologists and the American Pancreatic Association. Adoption of this standardized imaging reporting template should improve the decision-making process for the management of patients with pancreatic ductal adenocarcinoma by providing a complete, pertinent, and accurate reporting of disease staging to optimize treatment recommendations that can be offered to the patient. Standardization
E ﬀ ect of Holes on Dynamic Crack Propagation under Impact Loading

: In civil, geotechnical, and mining engineering, the investigation of the holes’ e ﬀ ect on dynamic crack propagation is essential because it can be used to predict possible fracture and protect cracked structures being further damaged. In this paper, a specimen made from polymethyl methacrylate (PMMA) with a pre-crack and two holes was proposed, and the Split-Hopkinson pressure bar was employed to investigate the e ﬀ ect of holes on dynamic crack propagation under impact loading. Notably, the locations of the holes were well designed with di ﬀ erent two-hole spacing (12 mm, 16 mm, and 20 mm) and crack-hole distance (15 mm, 30 mm, and 45 mm). Crack propagation gauges were applied to monitor the fracturing time and crack extending velocity. The interaction characteristic between the crack and two holes was studied numerically using the AUTODYN code. In the numerical models, the failure criteria of maximum tensile stress and softening damage were employed for brittle material. The crack path, the propagating velocity, the particle velocity vector, and the stress state between the holes were analyzed. The calculation results indicate that compressive stresses between the two holes induced by the deformation of the holes play a crucial role in conﬁning the vertical crack propagation. Both experimental and numerical results demonstrate that the holes have a suppressing action on the moving crack; as the two-hole spacing decreases, the suppressing action intensiﬁes.
Genetic Analysis of B55 (cid:1) /Cdc55 Protein Phosphatase 2A Subunits: Association with the Adenovirus E4orf4 Protein (cid:1)

The human adenovirus E4orf4 protein is toxic in both human tumor cells and Saccharomyces cerevisiae . Previous studies indicated that most of this toxicity is dependent on an interaction of E4orf4 protein with the B55 class of regulatory subunits of protein phosphatase 2A (PP2A) and in yeast with the B55 homolog Cdc55. We have found previously that E4orf4 inhibits PP2A activity against at least some substrates. In an attempt to understand the mechanism of this inhibition, we used a genetic approach to identify residues in the seven-bladed (cid:1) -propeller proteins B55 (cid:2) and Cdc55 required for E4orf4 binding. In both cases, amino-terminal polypeptides composed only of blade 1 and at least part of blade 2 were found to bind E4orf4 and ﬂanking
BYU ScholarsArchive BYU ScholarsArchive Counseling Attitudes and Stigma among Polynesian Americans Counseling Attitudes and Stigma among Polynesian Americans

There is a paucity of research on the mental health of Pacific Islanders living in the U.S., including those of Polynesian descent. This study examined coping strategies, attitudes towards seeking mental health counseling, public and self-stigma towards seeking professional help, and psychological adjustment among 638 Polynesian Americans. On average, participants held neither favorable nor unfavorable attitudes towards seeking professional psychological help, but Polynesian American men endorsed moderate self-stigma about mental illness and Polynesian American women endorsed high levels of public stigma about mental illness. Women showed relatively more favorable attitudes than men about seeking help from professional mental health providers. Participants reported benefitting from culturally congruent practices for coping with distress (accepting, reframing, striving, family support, and religiosity/spirituality) much more than seeking assistance from private emotional outlets (e.g., therapy) or avoidance and detachment. Findings indicate that mental health professionals will need to build effective cross-cultural bridges and culturally adapt services to address concerns among Polynesian Americans.
Lumbar disc herniation in patient with long-term postural in stabilty from achilles tendon rupture: A single case study Journal of Clinical Images and Medical Case Reports

Lumbar Disc Herniation (LDH) may be triggered by many factors acting on the posterior kinetic chain as foot posture, foot and ankles malalignment and abnormal proprioception. Achilles Tendon (AT) rupture can impact heel position, ankle biomechanics, proprioceptive regulation and promote postural instability. This single case study aims to highlight the long-term effects of AT rupture, and its unefficient rehabilitation, on trunk asymmetry that could lead to lumbar degenerative diseases. This study describes a 50 year old woman with long-term postural instabilty from past AT rupture, who undergone to surgery for LDH and physioteraphy. The tailored exercise program included three sessions/week of both physical activity on dry land and active/passive aquatic physiotherapy. Average number of daily steps performed along the patient’s diagnostic and therapeutic pathway has been used to compare the activity rate over time. The Functional Movement Screen, the Owestry Low Back Pain Disability and the Lower Extremity Functional scales have been used as main outcome measures. This work aims to propose an integrated approach to patients with LDH built (a) following the principles of individuality, causality and totality and (b) combining activities on dry land and hydrotherapy within the same physical session, to improve the efficacy of rehabilitation programmes for spine injuries.
Taking university business courses online: An instructional designer's perspective

This report details an instructional design project for the College of Business (COB) at the University of Northern Iowa, an average-sized Midwest university. During the project as an instructional designer, I converted an existing traditional face-to-face business readiness program (Business 1000, 2000, 3000, & 4000) to online/flipped/blended courses using the Blackboard Learning Management System. The process involved working with faculty, program heads, students, and the staff of the COB with the intention of lowering the technology bar of intimidation enough to integrate it with the pedagogy needs of the courses. This open access graduate research paper is available at UNI ScholarWorks: https://scholarworks.uni. edu/grp/614 Taking University Business Courses Online: An Instructional Designer's Perspective A Graduate Project Report Submitted to the Division of Instructional Technology Department of Curriculum and Instruction In Partial Fulfillment Of the Requirements for the Degree Master of Arts UNIVERSITY OF NORTHERN IOWA by Zachary P. Benton-Slocum March 2017 This Review by: Zachary P. Benton-Slocum Titled: Taking University Business Courses Online: An Instructional Designer's Perspective has been approved as meeting the research requirement for the Degree of Master of Arts. lf/«1/17 ' Date Approved
Perceptions on Change: a Transformation Case Study

Every organization faces the need for change, but leaders may not understand what employees perceive to be positive change versus negative change during transformations. With this understanding, leaders can perform change activities better. In this longitudinal case study in a global supply chain, the author extracts positive and negative change attributes from the perspective of participants in a significant organizational change event. The study ultimately extracts 28 propositions for change from participants that relate to both positive and negative change, ultimately improving change leadership efficacy. The objective of the change leader would be to exploit the positive change drivers and mitigate the negative change drivers as per the propositions that emerged in the study. With work environments becoming more complex and ambiguous, leaders are looking to workers with tacit knowledge of their work and the ability to reach out globally for problem solving, to perceive change as constructive. With this perception employees will be more engaged in change events leading to success for change leaders. These outcomes can influence organizational change efficacy and so are useful for sustained corporate advantage.
Engineering Ethics in Engineering Design Courses: A Preliminary Investigation

and improve decision-making Abstract Engineering design entails countless decisions. A subset of those decisions involves ethical dimensions. While the answers to those decisions may not be self-evident, practice and education can help improve engineers’ decision quality during design processes. This research paper helps answer the question: what topics are engineering students exposed to when they learn about ethics in their design courses? Specifically, in what ways do design and ethics co-occur in engineering design courses? To answer this question, we collected course information from 60 universities and five disciplines. In particular, we looked at the program requirements for the top 60 engineering degree-granting universities. Across each university, we focused on the five most popular engineering programs. According to ASEE By the Numbers, in 2018 these disciplines were: chemical, civil, electrical, mechanical engineering, and computer science. For each program at each university (where applicable, since some universities did not have a degree program in one of these disciplines), we collected information about any course that mentioned ethics (or a lexical derivative) in either its title or course description. Examples include courses called “Introduction to Engineering Ethics” or “Professional Seminar” that mentioned ethics in its course description. From this collection of courses, we analyzed the course description using a text network mapping approach as a coarse, high-level overview of the language used to describe the intersection of ethics and design. The text networks technique begins with a mapping co-occurring words and phrases. With this initial accounting, we then formed a graph of nodes and edges to illustrate the network. Finally, we identified text network communities to capture persistent themes or topics. From our results, several lessons emerged. First, not unexpectedly, engineering ethics appears differently in design courses conditional on the specific discipline. Second, almost regardless of discipline, issues of professionalism - what it means to be a member of a profession - also appear with these same issues. Third, these design courses tend to include not only design but also an array of other topics that traditionally fall under the umbrella of “professional skills” such as communication and teamwork. Future work based on these results can take this high-level evidence from course descriptions and look for more systematic variation within engineering design courses to provide more fine-grained details about observed intersections of engineering design and ethics in engineering classrooms.