Miracle-dz/UniFAR-FTUs huggingface dataset:
Organic Photovoltaic Pseudocapacitors for Neurostimulation

Neural interfaces are the fundamental tools to understand the brain and cure many nervous-system diseases. For proper interfacing, seamless integration, efficient and safe digital-to-biological signal transduction, and long operational lifetime are required. Here, we devised a wireless optoelectronic pseudocapacitor converting the optical energy to safe capacitive currents by dissociating the photogenerated excitons in the photovoltaic unit and effectively routing the holes to the supercapacitor electrode and the pseudocapacitive electrode–electrolyte interfacial layer of PEDOT:PSS for reversible faradic reactions. The biointerface showed high peak capacitive currents of ∼3 mA·cm–2 with total charge injection of ∼1 μC·cm–2 at responsivity of 30 mA·W–1, generating high photovoltages over 400 mV for the main eye photoreception colors of blue, green, and red. Moreover, modification of PEDOT:PSS controls the charging/discharging phases leading to rapid capacitive photoresponse of 50 μs and effective membrane depolarization at the single-cell level. The neural interface has a device lifetime of over 1.5 years in the aqueous environment and showed stability without significant performance decrease after sterilization steps. Our results demonstrate that adopting the pseudocapacitance phenomenon on organic photovoltaics paves an ultraefficient, safe, and robust way toward communicating with biological systems.
Studies on Anatomy of Development of Female Flower in Carya cathayensis Sarg.

To understand the law of flower-bud differentiation in Carya cathayensis sarg. ,the development of female flower was studied comprehensively in its ultrastructure,microstructure and macrostructure.Differentiation of female flower begins generally from the last 10 days in March,till the second 10 days in May when the flower's development is basically completed.The whole process needs about 35 days totally.The whole process can be divided into 5 stages,the undifferentiated stage,the initial stage of flower bud differentiation and the stage of formation and development of the inflorescence,of the female involucre,and of the pistil.At the first stage,the exterior appearance of pistillate flower bud has no differentiation with leaf bud.At the second stage,the top tends to take the shape of hemisphere,the exterior appearance has no variety.At the third stage three flower primordia are formed.As to the exterior appearance,the flower bud is ambiguous,therefore,every tiny flower forms a total husk and three small husks around.at the fourth stage the floret is already obvious.Therefore,at the last stage the tiny flower and ovule embryo sac begin to develop.
Bragg Grating Assisted Sagnac Interferometer in SiO2-Al2O3-La2O3 Polarization-Maintaining Fiber for Strain–Temperature Discrimination

Polarization-maintaining fibers (PMFs) have always received great attention in fiber optic communication systems and components which are sensitive to polarization. Moreover, they are widely applied for high-accuracy detection and sensing devices, such as fiber gyroscope, electric/magnetic sensors, multi-parameter sensors, and so on. Here, we demonstrated the combination of a fiber Bragg grating (FBG) and Sagnac interference in the same section of a new type of PANDA-structure PMF for the simultaneous measurement of axial strain and temperature. This specialty PMF features two stress-applied parts made of lanthanum-aluminum co-doped silicate (SiO2-Al2O3-La2O3, SAL) glass, which has a higher thermal expansion coefficient than borosilicate glass used commonly in commercial PMFs. Furthermore, the FBG inscribed in this SAL PMF not only aids the device in discriminating strain and temperature, but also calibrates the phase birefringence of the SAL PMF more precisely thanks to the much narrower bandwidth of grating peaks. By analyzing the variation of wavelength interval between two FBG peaks, the underlying mechanism of the phase birefringence responding to temperature and strain is revealed. It explains exactly the sensing behavior of the SAL PMF based Sagnac interference dip. A numerical simulation on the SAL PMF’s internal stress and consequent modal effective refractive indices was performed to double confirm the calibration of fiber’s phase birefringence.
Mendelian Randomization Analysis of Hemostatic Factors and Their Contribution to Peripheral Artery Disease—Brief Report

Supplemental Digital Content is available in the text. Background and Objective: Peripheral artery disease (PAD) is the third most common form of atherosclerotic vascular disease and is characterized by significant functional disability and increased cardiovascular mortality. Recent genetic data support a role for a procoagulation protein variant, the factor V Leiden mutation, in PAD. The role of other hemostatic factors in PAD remains unknown. We evaluated the role of hemostatic factors in PAD using Mendelian randomization. Approach and Results: Two-sample Mendelian randomization to evaluate the roles of FVII (factor VII), FVIII (factor VIII), FXI (factor XI), VWF (von Willebrand factor), and fibrinogen in PAD was performed using summary statistics from GWAS for hemostatic factors performed within the Cohorts for Heart and Aging Research in the Genome Epidemiology Consortium and from GWAS performed for PAD within the Million Veteran Program. Genetically determined FVIII and VWF, but not FVII, FXI, or fibrinogen, were associated with PAD in Mendelian randomization experiments (FVIII: odds ratio, 1.41 [95% CI, 1.23–1.62], P=6.0×10−7, VWF: odds ratio, 1.28 [95% CI, 1.07–1.52], P=0.0073). In single variant sensitivity analysis, the ABO locus was the strongest genetic instrument for both FVIII and VWF. Conclusions: Our results suggest a role for hemostasis, and by extension, thrombosis in PAD. Further study is warranted to determine whether VWF and FVIII independently affect the biology of PAD.
Rhizobium laguerreae Improves Productivity and Phenolic Compound Content of Lettuce (Lactuca sativa L.) under Saline Stress Conditions

Lettuce (Lactuca sativa L.) is a widely consumed horticultural species. Its significance lies in a high polyphenolic compound content, including phenolic acids and flavonols. In this work, we have probed the ability of Rhizobium laguerreae HUTR05 to promote lettuce growth, under in vitro and greenhouse conditions (both non-saline and saline conditions). This strain has shown several in vitro plant growth promotion mechanisms, as well as capacity to colonize lettuce seedlings roots. We have analyzed the effect of the rhizobacterium inoculation on mineral and bioactive compounds in lettuce, under greenhouse conditions, and found a rise in the content of certain phenolic acids and flavonoids, such as derivatives of caffeoyl acid and quercetin. The genome analysis of the strain has shown the presence of genes related to plant growth-promoting rhizobacteria (PGPR) mechanisms, defense from saline stress, and phenolic compound metabolism (such as naringenin-chalcone synthase or phenylalanine aminotransferase).
Improvements in patients with lipedema 4, 8 and 12 years after liposuction

Background Long-term results following liposuction in patients with lipedema were available only for an average period of 8 years. Objective To find out whether the improvements persist for a further 4 years. Methods In 60 patients with lipedema a single-centre study with a mail questionnaire – often in combination with clinical controls – was performed after an average period of 12 years following liposuction(s). All patients in this group had already been surveyed 4 and 8 years after surgery. Results Compared with the earlier results improvement persisted with regard to spontaneous pain, sensitivity to pressure, edema, bruising and restriction of movement; similar outcomes were observed for self-assessment of cosmetic impairment, reduction in quality of life and overall impairment. While in the period from 4 to 8 years postoperatively complaints slightly increased, this was not the case for the period 8 to 12 years postoperatively. In addition a similar reduction of conservative treatment (decongestive therapy, compression garments) was observed as after 4 and 8 years postoperatively. Compared with the body weight before liposuction, 55% of the patients showed a reduction of 6.2 kg on average and 43.3% had a weight increase with an average of 7.9 kg. Conclusion The results show, that the positive effects of liposuction last 12 years postoperatively without relevant worsening. They imply that liposuction for lipedema leads to a permanent reduction of symptom severity and need for conservative therapy.
Identifying Gene Signatures for Cancer Drug Repositioning Based on Sample Clustering

Drug repositioning is an important approach for drug discovery. Computational drug repositioning approaches typically use a gene signature to represent a particular disease and connect the gene signature with drug perturbation profiles. Although disease samples, especially from cancer, may be heterogeneous, most existing methods consider them as a homogeneous set to identify differentially expressed genes (DEGs)for further determining a gene signature. As a result, some genes that should be in a gene signature may be averaged off. In this study, we propose a new framework to identify gene signatures for cancer drug repositioning based on sample clustering (GS4CDRSC). GS4CDRSC first groups samples into several clusters based on their gene expression profiles. Second, an existing method is applied to the samples in each cluster for generating a list of DEGs. Then a weighting approach is used to identify an intergrated gene signature from all the lists of DEGs. The integrated gene signature is used to connect with drug perturbation profiles in the Connectivity Map (CMap)database to generate a list of drug candidates. GS4CDRSC has been tested with several cancer datasets and existing methods. The computational results show that GS4CDRSC outperforms those methods without the sample clustering and weighting approaches in terms of both number and rate of predicted known drugs for specific cancers.
A meta-analysis

Background:The results from previous studies on association between prostaglandin E receptor 4 (PTGER4) polymorphisms and inflammatory bowel disease (IBD) risk in Caucasian were conflict. The present study aimed to investigate the genetic association by conducting a meta-analysis. Methods: Systematic literature search was conducted through Wiley Online Library, Chinese National Knowledge Infrastructure (CNKI), and PubMed databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to investigate the associations between rs4613763T/C, 17234657T/G polymorphisms, and IBD risk in Caucasian. Results:Twenty case-control studies consisting of 18,495 Crohn disease (CD) patients and 4203 ulcerative colitis (UC) patients, as well as 26,063 controls were included in this meta-analysis. The rs4613763T/C polymorphism had obvious influence on CD, UC risk in Caucasian. However, rs17234657T/G polymorphism had obvious influence on CD but not UC in Caucasian. Conclusion: This meta-analysis suggested that both the rs4613763T/C, rs17234657T/G polymorphisms had obvious influence on risk of CD in Caucasian. In addition, rs4613763T/C, polymorphism had obvious influence on risk of UC in Caucasian. Abbreviations: CD = Crohn disease, CI = confidence interval, CNKI = Chinese National Knowledge Infrastructure, IBD = inflammatory bowel disease, OR = odds ratio, PTGER4 = prostaglandin E receptor 4, UC = ulcerative colitis.
Scalable cultivation of engineered cyanobacteria for squalene production from industrial flue gas in a closed photobioreactor.

Economically feasible photosynthetic cultivation of microalgal and cyanobacterial strains is crucial for biological conversion of CO2 and potential CO2 mitigation to challenge global warming. To overcome the economic barriers, the production of value-added chemicals was desired by compensating for the overall processing cost. Here, we engineered cyanobacteria for photosynthetic squalene production and cultivated them in a scalable photobioreactor using industrial flue gas. First, an inducer-free gene expression system was developed for the cyanobacteria to lower production costs. Then, the recombinant cyanobacteria were cultivated in a closed photo-bioreactor (100 L) using flue gas (5% CO2) as the sole carbon source under natural sunlight as the only energy source. Seasonal light intensities and temperatures were analyzed along with cyanobacterial cell growth and squalene production in August and October 2019. As a result, the effective irradiation hour was the most critical factor for the large-scale cultivation of cyanobacteria. Thus, an automated photo-bioprocess system will be developed based on the regional light sources.
Noninvasive brain stimulation for patients with a disorder of consciousness: a systematic review and meta-analysis

Abstract Noninvasive brain stimulation (NIBS) techniques have been used to facilitate the recovery from prolonged unconsciousness as a result of brain injury. The aim of this study is to systematically assess the effects of NIBS in patients with a disorder of consciousness (DOC). We searched four databases for any randomized controlled trials on the effect of NIBS in patients with a DOC, which used the JFK Coma Recovery Scale-Revised (CRS-R) as the primary outcome measure. A random-effects meta-analysis was conducted to pool effect sizes. Fourteen studies with 273 participants were included in this review, of which 12 studies with sufficient data were included in the meta-analysis. Our meta-analysis showed a significant effect on increasing CRS-R scores in favor of real stimulation as compared to sham (Hedges’ g = 0.522; 95% confidence interval [CI], 0.318–0.726; P < 0.0001, I 2 = 0.00%). Subgroup analysis demonstrated that only anodal transcranial direct current stimulation (tDCS) of the left dorsolateral prefrontal cortex (DLPFC) significantly enhances the CRS-R scores in patients with a DOC, as compared to sham (Hedges’ g = 0.703; 95% CI, 0.419–0.986; P < 0.001), and this effect was predominant in patients in a minimally conscious state (MCS) (Hedges’ g = 0.815; 95% CI, 0.429–1.200; P < 0.001). Anodal tDCS of the left DLPFC appears to be an effective approach for patients with MCS.
Growth charts for individuals with Coffin‐Siris syndrome

Coffin‐Siris syndrome (CSS; OMIM #135900) is a rare, multisystem syndrome caused by pathogenic variants in genes encoding the BRG‐1 associated factors complex (BAF). Individuals with CSS often present with feeding difficulties and failure to thrive during infancy, in addition to a number of variable congenital anomalies. Nutritional interventions are used to support growth in this population, and growth hormone therapy has been reported in a limited number of cases. The purpose of this study was to construct CSS‐specific growth charts to better characterize the growth in this population. Anthropometric data were collected from 99 individuals enrolled in the CSS/BAF pathway international registry via a retrospective chart review. All measurements obtained after the first exposure to growth hormone therapy were excluded from this analysis. Sex‐specific centiles (5th, 50th, and 95th) were estimated for height, weight, and head circumference from birth to age 10. Cubic smoothing splines were then fit to the centile estimates and superimposed on normative male and female growth curves for comparison. The CSS patients in this cohort exhibited normal growth parameters at birth. By age 10, the weight and head circumference of the CSS cohort began to approach normal parameters. Stature, however, remained shortened at 10 years of age.
Continuous Neuromuscular Blockade Following Successful Resuscitation From Cardiac Arrest: A Randomized Trial

Background Neuromuscular blockade (NMB) agents are often administered to control shivering during targeted temperature management following cardiac arrest. In this study, we hypothesized that early, continuous NMB would result in a greater reduction in serum lactate levels among comatose patients after cardiac arrest. Methods and Results Randomized trial of continuous NMB for 24 hours versus usual care following cardiac arrest conducted at 5 urban centers in the United States. Adult patients who achieved return of spontaneous circulation, remained unresponsive, and underwent targeted temperature management after cardiac arrest were included. The primary outcome was change in lactate over 24 hours. A total of 83 patients were randomized, and 80 were analyzed (37 and 43 in the NMB and usual care arms, respectively). There was no significant interaction between time and treatment group with respect to change in lactate over 24 hours (median lactate change from 4.2 to 2.0 mmol/L [−2.2 mmol/L] in the NMB arm versus 4.0 to 1.7 mmol/L [−2.3 mmol/L] in the usual care arm; geometric mean difference, 1.3 [95% CI, 1.0–1.8]; P=0.07 for the interaction term). There was no difference in hospital survival (38% [NMB] versus 33% [usual care]; P=0.63) or survival with good functional outcome (30% [NMB] versus 21% [usual care]; P=0.35). There were no adverse events in either arm attributed to study interventions. Conclusions Continuous NMB compared with usual care did not reduce lactate over the first 24 hours after enrollment compared with usual care. There was no difference in overall hospital survival, hospital survival with good neurologic outcome, or adverse events. Registration URL: https://www.clinicaltrials. gov; Unique identifier: NCT02260258.
Self-Supervised Learning Combined Group and Instance Discrimination for Small Sample SAR ATR

Some Synthetic aperture radar (SAR) target images are challenging to acquire and costly to label. Self-supervised learning is available for SAR Automatic Target Recognition(SAR, ATR) applied to small samples, but the poor discrimination of SAR images and the large similarity between samples are not conducive to self-supervised learning for instance discrimination. In this paper, we proposed a self-supervised learning framework combining group instance discrimination for SAR ATR. For SAR target images, one branch is instance discrimination and the other branch is group-instance discrimination. Group instances are specifically formed by using feature clustering in a batch of instance samples and finding the centroids of groups. Then the SAR Group Instance Discriminant Loss is updated to metric the distance between the input instance eigenvectors and the centroids and converge them to the closest distance group, so that the similar eigenvectors in different clusters can be distinguished. It is experimentally concluded that this method can achieve high recognition rate with limited annotated SAR images, surpassing the performance of traditional transfer learning and self-supervised learning methods on SAR ATR tasks.
Microstructures and Mechanical Properties of Al-2Fe-xCo Ternary Alloys with High Thermal Conductivity

The microstructures, mechanical properties, and thermal conductivity (TC) of Al-2Fe-xCo (x = 0~0.8) alloys in as-cast, homogeneous annealed, and cool rolled states are systematically studied. Results indicate that appropriate Co modification (x ≤ 0.5) simultaneously improves the thermal and mechanical properties of as-cast Al-2Fe alloys. The improvement of TC is attributed to ameliorating the morphology of primary Al3Fe phases from needles to short rods and fine particles, which decreases the scattering probability of free electrons during the electronic transmission. However, further increasing the Co content (x = 0.8) decreases the TC due to the formation of a coarse plate-like Al2FeCo phase. Besides, the thermal conductivity of annealed Al-2Fe-xCo alloys is higher than that of as-cast alloys because of the elimination of lattice defects and spheroidization of Al3Fe phases. After cool rolling with 80 % deformation, thermal conductivity of alloys slightly increases due to the breaking down of Al2FeCo phases. The rolled Al-2Fe-0.3Co alloy exhibits the highest thermal conductivity, which is about 225 W/(m·K), approximately 11 % higher than the as-cast Al-2Fe sample. The ultimate tensile strength (UTS) and elongation (EL) of as-cast Al-2Fe-0.5Co (UTS: 138 MPa; EL: 22.0 %) are increased by 35 % and 69 %, respectively, compared with those of unmodified alloy (UTS: 102 MPa; EL: 13.0 %).
Study on Dormancy Characteristics of Potato with Different Generations and Weights

With the microtubers,pre-basic seeds,basic seeds and production seeds of the variety Shuyin 1 as materials,the differences of dormancy characteristics of different generations of potato were studied.The results showed that the dormancy time and sprouting time of microtubers were the longest followed by production seeds,but there were no significant differences between pre-basic and basic seeds.The dormancy differences of potato with different weights were also studied with the variety Zaodabai as material.The results showed that the smaller the potato was,the shorter the dormancy time and sprouting time were,and the more obvious the effect of gibberellic acid was.At last,the effect of moisture on tuber dormancy was studied with the microtubers of Zaodabai as material,and the results showed that high moisture could significantly shorten the dormancy time,when the temperature was above 15℃.
Daily Eating Frequency in US Adults: Associations with Low-Calorie Sweeteners, Body Mass Index, and Nutrient Intake (NHANES 2007–2016)

Studies of relationships between eating frequency and/or timing and energy intake have not examined associations with low-calorie sweeteners (LCS). We assessed the frequency of eating behavior related to LCS consumption emphasizing timing, calorie intake, and body mass index (BMI) among United States (US) adults aged ≥19 years. Using the National Health and Nutrition Examination Survey (NHANES) 2007–2016, we defined eating episodes as food and/or beverage intake within 15 min of one another over the first 24-h dietary recall. We coded items ingested during episodes (n = 136,938) and assessed LCS presence using US Department of Agriculture (USDA) food files. Episode analysis found intakes of foods only (27.4%), beverages only (29.5%), and foods with beverages (43.0%). LCS items were consumed without concurrent calories from other sources in fewer than 2.7% of all episodes. Within participants having normal weight (29.4%), overweight (33.6%) and obese (37.1%) BMIs, LCS consumers (35.2% overall) evidenced: more episodes/day; and fewer: calories, carbohydrates, fats, and protein per episode. Per person, those consuming LCS had lower total calories and higher fiber intake per day. LCS consumption was associated with higher BMI. Number of eating episodes/day and longer hours when eating episodes occurred were also consistently associated with higher BMI. Consuming LCS did not modify these relationships. These results did not show that LCS consumption was associated with increased caloric intake from other dietary sources.