Miracle-dz/UniFAR-FTUs huggingface dataset:
Sparsity-Based Spatiotemporal Fusion via Adaptive Multi-Band Constraints

Remote sensing is an important means to monitor the dynamics of the earth surface. It is still challenging for single-sensor systems to provide spatially high resolution images with high revisit frequency because of the technological limitations. Spatiotemporal fusion is an effective approach to obtain remote sensing images high in both spatial and temporal resolutions. Though dictionary learning fusion methods appear to be promising for spatiotemporal fusion, they do not consider the structure similarity between spectral bands in the fusion task. To capitalize on the significance of this feature, a novel fusion model, named the adaptive multi-band constraints fusion model (AMCFM), is formulated to produce better fusion images in this paper. This model considers structure similarity between spectral bands and uses the edge information to improve the fusion results by adopting adaptive multi-band constraints. Moreover, to address the shortcomings of the ℓ 1 norm which only considers the sparsity structure of dictionaries, our model uses the nuclear norm which balances sparsity and correlation by producing an appropriate coefficient in the reconstruction step. We perform experiments on real-life images to substantiate our conceptual augments. In the empirical study, the near-infrared (NIR), red and green bands of Landsat Enhanced Thematic Mapper Plus (ETM+) and Moderate Resolution Imaging Spectroradiometer (MODIS) are fused and the prediction accuracy is assessed by both metrics and visual effects. The experiments show that our proposed method performs better than state-of-the-art methods. It also sheds light on future research.
De novo protein structure prediction using ultra-fast molecular dynamics simulation

Modern genomics sequencing techniques have provided a massive amount of protein sequences, but experimental endeavor in determining protein structures is largely lagging far behind the vast and unexplored sequences. Apparently, computational biology is playing a more important role in protein structure prediction than ever. Here, we present a system of de novo predictor, termed NiDelta, building on a deep convolutional neural network and statistical potential enabling molecular dynamics simulation for modeling protein tertiary structure. Combining with evolutionary-based residue-contacts, the presented predictor can predict the tertiary structures of a number of target proteins with remarkable accuracy. The proposed approach is demonstrated by calculations on a set of eighteen large proteins from different fold classes. The results show that the ultra-fast molecular dynamics simulation could dramatically reduce the gap between the sequence and its structure at atom level, and it could also present high efficiency in protein structure determination if sparse experimental data is available.
Causal explanations for lack of pregnancy applying the common sense model of illness representation to the fertility context

Abstract Objectives: The current study explored causal explanations for lack of pregnancy and association with help-seeking behaviour. Differences based on gender and country Human Development Index were examined. Design: A mixed method design was used. Main outcome measures: Data were drawn from the International Fertility Decision-Making Study, a cross-sectional study of 10,045 individuals (1690 men; 8355 women) from 79 countries. Respondents rated to what extent they believed their lack of pregnancy was due to something they or their partner had done/not done or other factors and described their reasons for making this rating. Results: Respondents were aged 18–50 (M = 31.83) years, partnered and had been trying to achieve a pregnancy/father a child for over six months (M = 2.8 years). Men and women primarily believed their lack of pregnancy was due to medical problems or chance/bad luck. Thematic analysis of textual responses from 29.7% of the sample found that respondents focused on their personal experience or a salient life event when describing the cause of their lack of pregnancy. Women expressed more regret and helplessness about causes than men. Significant country differences were observed. Conclusions: Individuals may develop inaccurate causal explanations based on their personal experiences. Access to accurate information is necessary to facilitate timely help-seeking.
Washing or filtering of blood products does not improve outcome in a rat model of trauma and multiple transfusion

Transfusion is associated with organ failure and nosocomial infection in trauma patients, which may be mediated by soluble bioactive substances in blood products, including extracellular vesicles (EVs). We hypothesize that removing EVs, by washing or filtering of blood products, reduces organ failure and improves host immune response.
Perceptions of Seasonal Influenza and Pneumococcal Vaccines Among Older Chinese Adults.

Background and Objectives Seasonal influenza can lead to pneumonia. In Hong Kong, deaths from pneumonia increased steadily from 2001 to 2015, and pneumonia was the second most common cause of death between 2012 and 2015. The seasonal influenza vaccine and pneumococcal vaccine have been clinically proven as effective measures against these two diseases among older adults, who are at particularly high risk. Despite the availability of vaccine subsidies, however, more than 60% of older adults in Hong Kong remain unvaccinated against pneumococcal diseases and seasonal influenza. The objective of this study was to investigate the perceptions and barriers associated with the seasonal influenza and pneumococcal vaccinations among older adults in Hong Kong. Research Design and Methods A qualitative approach of individual semistructured interviews was adopted; 40 adults aged 65 years and older were interviewed between September and November 2016. Results The intersecting influences of belief of vaccines as harmful, low perceived risk of contracting the diseases, negative rumors about the vaccines, lack of promotion by health care providers, the perceived risk posed by the vaccinating locations, and the preference of using traditional Chinese medicine were discovered to prevent the participants from receiving the two vaccinations. Discussion and Implications Perceptions and cultural factors should be considered in future vaccination promotion among older adults. This study found that, in particular, the participants' cultural associations and stereotypes of hospitals and clinics and health care providers' lack of perceived need to vaccinate older adults contributed to low vaccine acceptance among the participants.
Multi-Branch Deep Residual Network for Single Image Super-Resolution

Recently, algorithms based on the deep neural networks and residual networks have been applied for super-resolution and exhibited excellent performance. In this paper, a multi-branch deep residual network for single image super-resolution (MRSR) is proposed. In the network, we adopt a multi-branch network framework and further optimize the structure of residual network. By using residual blocks and filters reasonably, the model size is greatly expanded while the stable training is also guaranteed. Besides, a perceptual evaluation function, which contains three parts of loss, is proposed. The experiment results show that the evaluation function provides great support for the quality of reconstruction and the competitive performance. The proposed method mainly uses three steps of feature extraction, mapping, and reconstruction to complete the super-resolution reconstruction and shows superior performance than other state-of-the-art super-resolution methods on benchmark datasets.
TIP41 network analysis and mutant phenotypes predict interactions between the TOR and ABA pathways

ABSTRACT Environmental conditions inform the rate of plant growth and development. The target of rapamycin (TOR) signalling pathway is a central regulator of plant growth in response to nutrients and energy, while abscisic acid (ABA) is a main mediator of abiotic stress responses. We recently characterized Arabidopsis TIP41, a predicted TOR pathway component involved in the ABA-mediated response to abiotic stress. Here, we report the ABA sensitivity of tip41 mutants, supporting the relation between TIP41 and the hormone pathway. The analysis of predicted TIP41 functional network identified several protein phosphatases. In particular, candidate protein interactors included catalytic subunits of type 2A protein phosphatases and protein phosphatases 6, which regulate different developmental processes and responses to environmental stimuli. These results provide important information on the role of TIP41 in the cross talk between TOR and ABA pathways.
Wolbachia Infection Associated with Increased Recombination in Drosophila

Wolbachia is a maternally-transmitted endosymbiotic bacteria that infects a large diversity of arthropod and nematode hosts. Some strains of Wolbachia are parasitic, manipulating host reproduction to benefit themselves, while other strains of Wolbachia exhibit obligate or facultative mutualisms with their host. The effects of Wolbachia on its host are many, though primarily relate to host immune and reproductive function. Here we test the hypothesis that Wolbachia infection alters the frequency of homologous recombination during meiosis. We use D. melanogaster as a model system, and survey recombination in eight wild-derived Wolbachia-infected (strain wMel) and Wolbachia-uninfected strains, controlling for genotype. We measure recombination in two intervals of the genome. Our results indicate that Wolbachia infection is associated with increased recombination in one genomic interval and not the other. The effect of Wolbachia infection on recombination is thus heterogenous across the genome. Our data also indicate a reproductive benefit of Wolbachia infection; infected females show higher fecundity than their uninfected genotypic controls. Given the prevalence of Wolbachia infection in natural populations, our findings suggest that Wolbachia infection is likely to contribute to recombination rate and fecundity variation among individuals in nature.
Metabolic remodelling of glucose, fatty acid and redox pathways in the heart of type 2 diabetic mice

Hearts from type 2 diabetic animals display perturbations in excitation–contraction coupling, impairing myocyte contractility and delaying relaxation, along with altered substrate consumption patterns. Under high glucose and β‐adrenergic stimulation conditions, palmitate can, at least in part, offset left ventricle (LV) dysfunction in hearts from diabetic mice, improving contractility and relaxation while restoring coronary perfusion pressure. Fluxome calculations of central catabolism in diabetic hearts show that, in the presence of palmitate, there is a metabolic remodelling involving tricarboxylic acid cycle, polyol and pentose phosphate pathways, leading to improved redox balance in cytoplasmic and mitochondrial compartments. Under high glucose and increased energy demand, the metabolic/fluxomic redirection leading to restored redox balance imparted by palmitate helps explain maintained LV function and may contribute to designing novel therapeutic approaches to prevent cardiac dysfunction in diabetic patients.
Prevention of preeclampsia in high-risk patients with low-molecular-weight heparin: a meta-analysis

Abstract Objective: To assess the secondary preventive effect of low-molecular-weight heparin (LMWH) on pregnant women with prior early-onset or severe preeclampsia (PE). Methods: A systematic literature search of several databases was conducted for randomized controlled trials comparing LMWH with either aspirin or no treatment in pregnant women at a high risk of placental-mediated pregnancy complications (PMPCs). Odds ratios and associated 95% confidence intervals (CI) and weighted mean differences and 95% CI were calculated. Results: Seven studies including 1035 patients were evaluated. These studies showed a risk reduction in composite PMPC outcome (relative risk (RR) 0.635 (95% CI: 0.436–0.925); p=. 018), PE (RR 0.522 (95% CI: 0.334–0.815); p=. 004), a small-for-gestational-age neonate (RR 0.622 (95% CI: 0.440–0.880); p=. 007), and an increase in gestational length (SMD 0.312 (95% CI: 0.017–0.607); p=. 038) and neonatal weight (SMD 0.428 (95% CI: 0.066–0.791); p=. 020). Conclusions: LMWH has a secondary preventive effect on early or severe PE and improves neonatal outcomes. In the future, additional large multicenter studies will need to focus on high-risk PE groups by more accurate screening to obtain more information before clinical application.
One ‘knows’: self-rated health and telomere length among ex-prisoners of war

Abstract Objective: Ill-health and early mortality are amongst the most significant ramifications of trauma. Furthermore, trauma alters the subjective perception and experience of the body. The aim of this study is to examine the extent to which deteriorations in perceived health among traumatised individuals are associated with cellular health as manifested in telomere length. Methods: Specifically, 88 former prisoners of war (ex-POWs) evaluated their health (self-rated health; SRH) at 18 (T1), 35 (T2) and 42 (T3) years after the war, and were assessed for telomere length at T3. Health behaviour, BMI, morbidity and PTSD were also examined at T3. Results: The findings demonstrated that SRH was cross-sectionally correlated with telomere length. Furthermore, a significant sequential indirect effect was found, in which worse SRH in T1 was associated with shorter telomere length at T3, through worse SRH at T2 and at T3. Conclusions: These findings demonstrate that long-term deteriorations in the subjective evaluations of health are implicated in actual cellular health among individuals exposed to trauma.
Molecular structure of the ATP-bound, phosphorylated human CFTR

Significance Mutations in cystic fibrosis transmembrane conductance regulator (CFTR) cause cystic fibrosis, a lethal genetic disease occurring in people of northern European descent. Decades of study have been directed toward a molecular understanding of this ion channel. The structure presented here enables a direct correlation of structure with function, most of which has been characterized in human CFTR. The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel important in maintaining proper functions of the lung, pancreas, and intestine. The activity of CFTR is regulated by ATP and protein kinase A-dependent phosphorylation. To understand the conformational changes elicited by phosphorylation and ATP binding, we present here the structure of phosphorylated, ATP-bound human CFTR, determined by cryoelectron microscopy to 3.2-Å resolution. This structure reveals the position of the R domain after phosphorylation. By comparing the structures of human CFTR and zebrafish CFTR determined under the same condition, we identified common features essential to channel gating. The differences in their structures indicate plasticity permitted in evolution to achieve the same function. Finally, the structure of CFTR provides a better understanding of why the G178R, R352Q, L927P, and G970R/D mutations would impede conformational changes of CFTR and lead to cystic fibrosis.
The combination of Caprini risk assessment scale and thrombotic biomarkers to evaluate the risk of venous thromboembolism in critically ill patients

Abstract To evaluate the correlation between the Caprini risk assessment scale and plasma thrombosis biomarkers and estimate the validity of this method in identifying critically ill patients at high risk of venous thromboembolism (VTE). Patients with VTE who were admitted to the intensive care unit (ICU) department of West China Hospital SiChuan University from October 2016 to October 2017 were enrolled in this case–control study. We retrieved relative clinical data and laboratory test results included in the Caprini risk assessment scale to calculate the Caprini score and compared thrombosis biomarkers between various risk stratifications (low, moderate, high, and highest). A total of 151 critically ill patients were enrolled in our research, including 47 VTE and 94 non-VTE patients. The differences in Caprini score and levels of thrombosis biomarkers between the VTE and control group were significant. Thrombomodulin (TM) was positively correlated with Caprini score (R-value was .451, P < .05). Based on the receiver operating characteristic analysis, TM, tissue plasminogen activator-inhibitor complexes, D-dimer, and fibrinogen degradation products had a certain diagnostic efficiency in distinguishing VTE from others (P < .05). Using the logistic regression model, we identified that 5 risk factors, namely drinking history, major surgery (>3 hours), swollen legs (current), TM, and D-dimer, were independent factors for the occurrence of VTE in critically ill patients admitted in the ICU. Thrombosis markers were positively correlated with Caprini risk stratification. The combination of plasma markers and Caprini risk assessment scale can further increase the predictive value in critically ill patients with VTE.
Effect of Dual-Carrier Processing on the Intelligibility of Concurrent Vocoded Sentences.

Purpose The goal of this study was to examine the role of carrier cues in sound source segregation and the possibility to enhance the intelligibility of 2 sentences presented simultaneously. Dual-carrier (DC) processing (Apoux, Youngdahl, Yoho, & Healy, 2015) was used to introduce synthetic carrier cues in vocoded speech. Method Listeners with normal hearing heard sentences processed either with a DC or with a traditional single-carrier (SC) vocoder. One group was asked to repeat both sentences in a sentence pair (Experiment 1). The other group was asked to repeat only 1 sentence of the pair and was provided additional segregation cues involving onset asynchrony (Experiment 2). Results Both experiments showed that not only is the "target" sentence more intelligible in DC compared with SC, but the "background" sentence intelligibility is equally enhanced. The participants did not benefit from the additional segregation cues. Conclusions The data showed a clear benefit of using a distinct carrier to convey each sentence (i.e., DC processing). Accordingly, the poor speech intelligibility in noise typically observed with SC-vocoded speech may be partly attributed to the envelope of independent sound sources sharing the same carrier. Moreover, this work suggests that noise reduction may not be the only viable option to improve speech intelligibility in noise for users of cochlear implants. Alternative approaches aimed at enhancing sound source segregation such as DC processing may help to improve speech intelligibility while preserving and enhancing the background.
Specialization of Resource Regions: a Mechanism for Applying Public-Private Partnerships

The research specifies the terminology and suggests an algorithm for identification of resource regions, as well as regions ready for smart specialization using cluster analysis. A distinctive feature of the algorithm is the complexity of the use of the justified and systematized groups of factors and indicators, including macroeconomic, infrastructural, innovative and resource ones. Taking into account the proposed algorithm, the authors’ classification of resource regions as well as regions prepared for smart specialization is presented, based on a consistent and complete division of regions into the groups proposed in the work. It was shown that the resource regions, depending on the degree of readiness for smart specialization, have a different level of PPP development. It is determined in the dynamics that the resource regions with higher readiness for smart specialization have a higher level of PPP development. While in resource regions unprepared for integrated development, as well as in enclave regions (regions with economic and infrastructure isolation from macro-regional and all-Russian ties), it is necessary to develop PPP mechanisms with the subsequent increase of the economic, infrastructural, innovative, personnel and qualification levels. This will allow for the organization of integrated exploitation with the involvement of the necessary volume of private investments for sustainable development in the long term. Keywords— resource regions, public-private partnerships, Russia, smart specializations.
Reproducible research practices, transparency, and open access data in the biomedical literature, 2015–2017

Currently, there is a growing interest in ensuring the transparency and reproducibility of the published scientific literature. According to a previous evaluation of 441 biomedical journals articles published in 2000–2014, the biomedical literature largely lacked transparency in important dimensions. Here, we surveyed a random sample of 149 biomedical articles published between 2015 and 2017 and determined the proportion reporting sources of public and/or private funding and conflicts of interests, sharing protocols and raw data, and undergoing rigorous independent replication and reproducibility checks. We also investigated what can be learned about reproducibility and transparency indicators from open access data provided on PubMed. The majority of the 149 studies disclosed some information regarding funding (103, 69.1% [95% confidence interval, 61.0% to 76.3%]) or conflicts of interest (97, 65.1% [56.8% to 72.6%]). Among the 104 articles with empirical data in which protocols or data sharing would be pertinent, 19 (18.3% [11.6% to 27.3%]) discussed publicly available data; only one (1.0% [0.1% to 6.0%]) included a link to a full study protocol. Among the 97 articles in which replication in studies with different data would be pertinent, there were five replication efforts (5.2% [1.9% to 12.2%]). Although clinical trial identification numbers and funding details were often provided on PubMed, only two of the articles without a full text article in PubMed Central that discussed publicly available data at the full text level also contained information related to data sharing on PubMed; none had a conflicts of interest statement on PubMed. Our evaluation suggests that although there have been improvements over the last few years in certain key indicators of reproducibility and transparency, opportunities exist to improve reproducible research practices across the biomedical literature and to make features related to reproducibility more readily visible in PubMed.