Miracle-dz/UniFAR-FTUs huggingface dataset:
A radially interleaved sodium and proton coil array for brain MRI at 7 T

The objective of the current study was to design and build a dual‐tuned coil array for simultaneous 23Na/1H MRI of the human brain at 7 T. Quality factor, experimental B1+ measurements, and electromagnetic simulations in prototypes showed that setups consisting of geometrically interleaved 1H and 23Na loops performed better than or similar to 1H or 23Na loops in isolation. Based on these preliminary findings, we built a transmit/receive eight‐channel 23Na loop array that was geometrically interleaved with a transmit/receive eight‐channel 1H loop array. We assessed the performance of the manufactured array with mononuclear signal‐to‐noise ratio (SNR) and B1+ measurements, along with multinuclear magnetic resonance fingerprinting maps and images. The 23Na array within the developed dual‐tuned device provided more than 50% gain in peripheral SNR and similar B1+ uniformity and coverage as a reference birdcage coil of similar size. The 1H array provided good B1+ uniformity in the brain, excluding the cerebellum and brain stem. The integrated 23Na and 1H arrays were used to demonstrate truly simultaneous quantitative 1H mapping and 23Na imaging.
Towards Consistency in Geometry Restraints for Carbohydrates in the Pyranose form: Modern Dictionary Generators Reviewed

Macromolecular restrained refinement is nowadays the most used method for improving the agreement between an atomic structural model and experimental data. Restraint dictionaries, a key tool behind the success of the method, allow fine-tuning geometric properties such as distances and angles between atoms beyond simplistic expectations. Dictionary generators can provide restraint target estimates derived from different sources, from fully theoretical to experimental and any combination in between. Carbohydrates are stereochemically complex biomolecules and, in their pyranose form, have clear conformational preferences. As such, they pose unique problems to dictionary generators and in the course of this study, require special attention from software developers. Functional differences between restraint generators will be discussed, as well as the process of achieving consistent results with different software designs. The study will conclude a set of practical considerations, as well as recommendations for the generation of new restraint dictionaries, using the improved software alternatives discussed.
Increased patency with comparable mortality and revascularization risk: Is the case for no‐touch vein harvesting open and shut?

Since the introduction of the saphenous vein graft (SVG) for coronary artery bypass grafting (CABG) in 19621, the SVG has remained the most commonly used conduit to the non-LAD territories for more than half a century. However, several issues surrounding the use of SVGs, including higher graft occlusion rates and wound complications from the harvesting process, have been identified in clinical practice. As such, significant interest has been dedicated towards developing harvesting techniques that minimize the risk of these acute and late complications. In this issue of the Journal of Cardiac Surgery, Yokoyama and colleagues compared the impact of open vein harvesting (OVH), endoscopic vein harvesting (EVH) and no-touch vein harvesting (NT) on all-cause mortality, revascularization and graft failure, using a network meta-analysis based on randomized controlled trials and propensity-score matched studies. The results showed that the risk of graft failure was approximately halved amongst patients receiving NT compared with EVH and OVH; importantly, though, NT was not associated with lower all-cause mortality or revascularization risk. To further examine whether the use of NT grafts endow patients with better long-term clinical outcomes, such as mortality, myocardial infarction, and revascularization rates, a large-scaled randomized controlled trial or a patient-level combined meta-analysis is required.
Early Menopause and Cardiovascular Disease Risk in Women With or Without Type 2 Diabetes: A Pooled Analysis of 9,374 Postmenopausal Women

OBJECTIVE Early menopause may be associated with higher cardiovascular disease (CVD) risk. Type 2 diabetes mellitus (T2DM), coupled with early menopause, may result in even greater CVD risk in women. We examined CVD risk in women with early compared with normal-age menopause, with and without T2DM overall, and by race/ethnicity. RESEARCH DESIGN AND METHODS We pooled data from the Atherosclerosis Risk in Communities study, the Multi-Ethnic Study of Atherosclerosis, and the Jackson Heart Study. We included women with data on menopausal status, menopausal age, and T2DM, excluding pre- or perimenopausal women and those with prevalent CVD. Outcomes included incident coronary heart disease (CHD), stroke, heart failure (HF), and atherosclerotic cardiovascular disease (ASCVD) (CHD or stroke). We estimated the risk associated with early (<45 years) compared with normal-age menopause using Cox proportional hazards models. Covariates included age, race/ethnicity, education, BMI, blood pressure, cholesterol, smoking, alcohol consumption, antihypertensive medication, lipid-lowering medication, hormone therapy use, and pregnancy history. RESULTS We included 9,374 postmenopausal women for a median follow-up of 15 years. We observed 1,068 CHD, 659 stroke, 1,412 HF, and 1,567 ASCVD events. T2DM significantly modified the effect of early menopause on CVD risk. Adjusted hazard ratios for early menopause and the outcomes were greater in women with T2DM versus those without (CHD 1.15 [95% CI 1.00, 1.33] vs. 1.09 [1.03, 1.15]; stroke 1.21 [1.04, 1.40] vs. 1.10 [1.04, 1.16]; ASCVD 1.29 [1.09, 1.51] vs. 1.10 [1.04, 1.17]; HF 1.18 [1.00, 1.39] vs. 1.09 [1.03, 1.16]). The modifying effect of T2DM on the association between early menopause and ASCVD was only statistically significant in Black compared with White women. CONCLUSIONS Early menopause was associated with an increased risk for CVD in postmenopausal women. T2DM may further augment the risk, particularly in Black women.
Reminiscence therapy exhibits alleviation of anxiety and improvement of life quality in postoperative gastric cancer patients

Abstract Although reminiscence therapy alleviates mental illness and improves quality of life in neurocognitive disorders patients, little study reports its clinical application in cancer patients. Thus, this study aimed to explore the effect of reminiscence therapy on anxiety, depression, quality of life, and survival profile in postoperative gastric cancer patients. One hundred sixty surgical gastric cancer patients were enrolled in this randomized, controlled study, then randomly assigned to Reminiscence therapy group (N = 80) and Control group (N = 80) as 1:1 ratio. The evaluation was carried at baseline (M0), month 3 (M3), month 6 (M6), month 9 (M9), and month 12 (M12) after intervention by Hospital Anxiety and Depression Scale and European Organization for Research and Treatment of Cancer quality of life Questionnaire-Core 30 (QLQ-C30). Furthermore, disease-free survival and overall survival were analyzed using follow-up data. Reminiscence therapy decreased HADS for anxiety score at M6, M9, and M12, decreased anxiety rate at M9 and M12 compared to control care; while it did not affect HADS for depression score or depression rate at any time-point. Also, reminiscence therapy raised QLQ-C30 global health status score at M12, reduced QLQ-C30 symptoms score at M6, while did not affect QLQ-C30 function score at any time-point compared to control care. Reminiscence therapy did not affect disease-free survival and overall survival, either. Further subgroup analyses (divided by age and gender) observed that the effect of reminiscence therapy seemed more obvious in patients with age ≤60 years and male patients. Reminiscence therapy exhibits alleviation of anxiety and improvement of quality of life in postoperative gastric cancer patients.
Increased Risk of Nonalcoholic Fatty Liver Disease in Individuals with High Weight Variability

Background Weight loss through lifestyle modification is recommended for patients with nonalcoholic fatty liver disease (NAFLD). Recent studies have suggested that repeated loss and gain of weight is associated with worse health outcomes. This study aimed to examine the association between weight variability and the risk of NAFLD in patients without diabetes. Methods We examined the health-checkup data of 30,708 participants who had undergone serial examinations between 2010 and 2014. Weight variability was assessed using coefficient of variation and the average successive variability of weight (ASVW), which was defined as the sum of absolute weight changes between successive years over the 5-year period divided by 4. The participants were classified according to the baseline body mass index and weight difference over 4 years. Results On dividing the participants into four groups according to ASVW quartile groups, those in the highest quartile showed a significantly increased risk of NAFLD compared to those in the lowest quartile (odds ratio [OR], 1.89; 95% confidence interval [CI], 1.63 to 2.19). Among participants without obesity at baseline, individuals with high ASVW showed increased risk of NAFLD (OR, 1.80; 95% CI, 1.61 to 2.01). Participants with increased weight over 4 years and high ASVW demonstrated higher risk of NAFLD compared to those with stable weight and low ASVW (OR, 4.87; 95% CI, 4.29 to 5.53). Conclusion Regardless of participant baseline obesity status, high weight variability was associated with an increased risk of developing NAFLD. Our results suggest that further effort is required to minimize weight fluctuations after achieving a desirable body weight.
Integration of quantitative diffusion kurtosis imaging and prostate specific antigen in differential diagnostic of prostate cancer

Abstract This study aimed to evaluate the diagnostic performance of diffusion kurtosis imaging (DKI) and prostate-specific antigen (PSA) biomarkers in differentiating prostate cancer (PCa) and benign prostatic hyperplasia (BPH). A total of 43 cases of prostate diseases verified by pathology were enrolled in the present study. These cases were assigned to the BPH group (n = 20, 68.85±10.81 years old) and PCa group (n = 23, 74.13 ± 7.37 years old). All patients underwent routine prostate magnetic resonance imaging and DKI examinations, and the mean diffusivity (MD), mean kurtosis (MK), and fractional anisotropy (FA) values were calculated. Three serum indicators (PSA, free PSA [fPSA], and f/t PSA) were collected. We used univariate logistic regression to analyze the above quantitative parameters between the 2 groups, and the independent factors were further incorporated into the multivariate logistic regression model. The area under the receiver operating characteristic curve (AUC) was used to evaluate the diagnostic efficacy of the single indicator and combined model. The difference in PSA, f/t PSA, MK, and FA between PCa and BPH was statistically significant (P < .05). The AUC for the combined model (f/t PSA, MK, and FA) of 0.972 (95% confidence interval [CI]: 0.928, 1.000) was higher than the AUC of 0.902 (95% CI: 0.801, 1.000) for f/t PSA, 0.833 (95% CI: 0.707, 0.958) for MK, and 0.807 (95% CI: 0.679, 0.934) for FA. The MK and FA values for DKI and f/t PSA effectively identify PCa and BPH, compared to the PSA indicators. Combining DKI and PSA derivatives can further improve the diagnosis efficiency and might help in the clinical setting.
Acute Effects of Foam Rolling on Blood Flow Measured by Ultrasonography in Soccer Players

Abstract Alonso-Calvete, A, Padrón-Cabo, A, Lorenzo-Martínez, M, and Rey, E. Acute Effects of Foam Rolling on Blood Flow Measured by Ultrasonography in Soccer Players. J Strength Cond Res 35(11): 3256–3259, 2021—In recent years, foam rolling (FR) has become a popular device for recovery to increase range of motion and decrease pain after sport practice and competition. However, there is little evidence about the underlying physiological effects of FR, specifically in blood flow parameters. Thus, the aim of this study was to analyze acute effects of FR on blood flow parameters (maximal velocity and maximal volume) measured by Doppler ultrasonography in soccer players. Twelve soccer players were assessed in 3 different situations: pre-FR intervention, immediately after FR intervention, and 30 minutes after FR intervention. The femoral artery was measured in the dominant leg with subjects in horizontal lying position. Before the intervention, subjects completed one familiarization session with FR. The FR intervention consisted of 2 sets, each with 45 seconds of FR and 15 seconds of rest between sets with a high-density foam roller in quadriceps, hamstrings, and iliotibial band. Results showed a significant increase in both maximal velocity (p < 0.001; effect size [ES] = 0.81) and maximal volume (p = 0.001; ES = 1.73) after intervention in comparison with pretest, but after 30 minutes, there were no significant differences. Therefore, this increase of the blood flow could promote important advantages for postexercise recovery, suggesting an acute effect that may contribute to the understanding of local physiological mechanism of FR.
Multi-Objective Neural Evolutionary Algorithm for Combinatorial Optimization Problems

There has been a recent surge of success in optimizing deep reinforcement learning (DRL) models with neural evolutionary algorithms. This type of method is inspired by biological evolution and uses different genetic operations to evolve neural networks. Previous neural evolutionary algorithms mainly focused on single-objective optimization problems (SOPs). In this article, we present an end-to-end multi-objective neural evolutionary algorithm based on decomposition and dominance (MONEADD) for combinatorial optimization problems. The proposed MONEADD is an end-to-end algorithm that utilizes genetic operations and rewards signals to evolve neural networks for different combinatorial optimization problems without further engineering. To accelerate convergence, a set of nondominated neural networks is maintained based on the notion of dominance and decomposition in each generation. In inference time, the trained model can be directly utilized to solve similar problems efficiently, while the conventional heuristic methods need to learn from scratch for every given test problem. To further enhance the model performance in inference time, three multi-objective search strategies are introduced in this work. Our experimental results clearly show that the proposed MONEADD has a competitive and robust performance on a bi-objective of the classic travel salesman problem (TSP), as well as Knapsack problem up to 200 instances. We also empirically show that the designed MONEADD has good scalability when distributed on multiple graphics processing units (GPUs).
Polyphosphate-induced Thrombosis in Mice is Factor XII-Dependent and is Attenuated by Histidine-rich Glycoprotein.

Histidine-rich glycoprotein (HRG) is an abundant plasma protein that binds factor (F) XIIa and inhibits FXII autoactivation and FXIIa-mediated activation of FXI. Polyphosphate (polyP), a potent procoagulant released from activated platelets, may serve as a physiological activator of the contact system. Previously, we showed that HRG binds DNA and neutralizes its procoagulant activity. Consequently, we set out to determine whether the capacity of HRG to bind polyanions enables it to regulate polyP-induced thrombosis. In a plate-based assay, immobilized polyP bound HRG, FXII, and FXIIa in a zinc-dependent manner. Basal and polyP-induced thrombin generation were greater in plasma from HRG-deficient mice than in plasma from wild-type mice. Intraperitoneal injection of polyP shortened the activated partial thromboplastin time, enhanced thrombin generation, increased thrombin-antithrombin (TAT) levels, reduced lung perfusion, and promoted pulmonary fibrin deposition to a greater extent in HRG-deficient mice than in wild-type mice, effects that were abrogated with FXII knockdown. Therefore, HRG attenuates the procoagulant and prothrombotic effects of polyP in a FXII dependent manner by modulating the contact system.
Influence of jump-landing direction on dynamic postural stability and hamstring-to-quadriceps co-activation ratio

ABSTRACT This study investigated the effect of jump landing direction and leg dominance on the Dynamic Postural Stability Index (DPSI) and the importance of the hamstring-to-quadriceps (H/Q) co-activation ratio. Fifteen female sports players performed unilateral jump landing, for the dominant (DL) and the non-dominant (NDL) legs in anterior (AJL), lateral (LJL), and vertical directions (DJL). The results indicated that the DPSI was higher in DJL compared to LJL and AJL. Besides, the DPSI score during DJL was higher in NDL indicating lower stabilization capacity associated with a lower H/Q co-activation ratio. A significant correlation was found between H/Q co-activation ratio and DPSI in the DL during AJL (r = −0.57). Current results suggest that DJL was more appropriate to evaluate dynamic postural stability since it highlights limb asymmetry. In addition, H/Q co-activation appears to play an essential role in the effectiveness of ground reaction force stabilization during jump landing.
Strategic basin and delta planning increases the resilience of the Mekong Delta under future uncertainty

Significance Globally, river deltas, which support some of the planet’s most productive agroeconomic systems and half a billion livelihoods, are at risk of being drowned by rising sea levels and accelerated subsidence. Whether delta land falls below sea level will depend on land and water management in the delta, sediment supply from the upstream basin, and global climate change. Those drivers cover multiple scales and domains and are rapidly changing, uncertain, and interconnected, which makes finding robust strategies to increase the resilience of river deltas challenging. Herein, we demonstrate an approach to identify planning levers that can increase the resilience of river deltas under a wide range of future conditions for the 40,000-km2 Mekong Delta in Southeast Asia. The climate resilience of river deltas is threatened by rising sea levels, accelerated land subsidence, and reduced sediment supply from contributing river basins. Yet, these uncertain and rapidly changing threats are rarely considered in conjunction. Here we provide an integrated assessment, on basin and delta scales, to identify key planning levers for increasing the climate resilience of the Mekong Delta. We find, first, that 23 to 90% of this unusually productive delta might fall below sea level by 2100, with the large uncertainty driven mainly by future management of groundwater pumping and associated land subsidence. Second, maintaining sediment supply from the basin is crucial under all scenarios for maintaining delta land and enhancing the climate resilience of the system. We then use a bottom-up approach to identify basin development scenarios that are compatible with maintaining sediment supply at current levels. This analysis highlights, third, that strategic placement of hydropower dams will be more important for maintaining sediment supply than either projected increases in sediment yields or improved sediment management at individual dams. Our results demonstrate 1) the need for integrated planning across basin and delta scales, 2) the role of river sediment management as a nature-based solution to increase delta resilience, and 3) global benefits from strategic basin management to maintain resilient deltas, especially under uncertain and changing conditions.
Matrix structure of dairy products results in different postprandial lipid responses: a randomized crossover trial.

BACKGROUND The dairy matrix may influence digestion and absorption of lipids and thereby risk of cardiovascular diseases (CVDs). However, few postprandial studies have compared dairy products that differed only in terms of their matrix. OBJECTIVES We aimed to investigate acute 8-h postprandial lipid, glycemic, and appetite responses after intake of isoenergetic dairy meals with different matrixes, but similar nutritional composition. METHODS Twenty-five normal-weight men (18-40 y old) were enrolled in a randomized controlled crossover trial. On 4 test days, a meal with 1 of 4 dairy products was served: cheddar cheese (Cheese), homogenized Cheese (Hom. Cheese), micellar casein isolate (MCI) with cream (MCI Drink), and a gel produced from the MCI Drink by addition of Glucono Delta-Lactone (MCI Gel). The fat- and protein-matched dairy products differed in terms of their casein network, fat droplet size, and/or texture. Blood biochemistry and appetite responses were collected. RESULTS Eighteen participants completed the trial. Postprandial triglycerides (TGs) (primary outcome) increased by (mean ± SEM) 0.24 ± 0.07 and 0.19 ± 0.07 mmol/L after MCI Gel compared with Cheese and Hom. Cheese, respectively (both P ≤ 0.05). Likewise, MCI Gel increased TG incremental AUC compared with Cheese and Hom. Cheese (both P < 0.05), and peak compared with Cheese (P < 0.05). ApoB-48 (primary outcome) was unaffected by dairy matrix. For free fatty acids (FFAs), glucose, and insulin, time × meal interactions were observed (all P < 0.001). During the first 2 h, FFAs were lower for Cheese than for MCI products, whereas the opposite was observed for glucose and insulin. CONCLUSIONS Postprandial TG but not apoB-48 response was higher after MCI Gel, indicating that the type of casein network influences lipid responses. This suggests that the dairy matrix may also affect risk factors for CVDs. Reducing fat droplet size (i.e., Hom. Cheese) did not affect blood biochemistry.This trial was registered at clinicaltrials.gov as NCT03656367.
Baseline Susceptibility of Leptinotarsa decemlineata (Coleoptera: Chrysomelidae) to Commonly Used Insecticides in the Columbia Basin

Abstract Colorado potato beetle (CPB), Leptinotarsa decemlineata Say (Coleoptera: Chrysomelidae), is one of the most challenging pests of potato, Solanum tuberosum L. , largely due to its propensity to develop insecticide resistance. Historically, L. decemlineata has rapidly evolved resistance to all major classes of synthetic insecticides, particularly in the eastern United States. However, in the U.S. Pacific Northwest, there have thus far been no confirmed reports of insecticide resistance despite anecdotal accounts of control failure. Hence, the objective of this study was to develop baseline data on the susceptibility of L. decemlineata in the Columbia Basin to abamectin, imidacloprid, and spinetoram, three insecticides commonly used to manage this insect. In 2018 and 2019, baseline susceptibility of four L. decemlineata populations, three from the Columbia Basin and one from Wisconsin (used as a resistant reference), was examined using topical LD50 bioassays. In general, L. decemlineata populations in the Columbia Basin exhibited relatively high sensitivity to imidacloprid, but variable sensitivity to abamectin and spinetoram among sites and years. Although small sample sizes hindered estimation of statistically significant LD50 values, results suggest that L. decemlineata in the Columbia Basin are beginning to develop levels of insensitivity to spinetoram, and possibly abamectin that are comparable to insecticide-resistant populations in Wisconsin. This preliminary examination of geographic variation in sensitivity to commonly used insecticides reinforces the value of rotating insecticide modes of action and suggests the need for continued monitoring for the development of insecticide resistance throughout the U.S. Pacific Northwest.