Miracle-dz/UniFAR-FTUs huggingface dataset:
The role of hormones in renal disease and ischemia-reperfusion injury

The patients with renal diseases, especially end-stage renal disease (ESRD), are at high risk of developing cardiovascular disturbances. Some hormones such as brain natriuretic peptide appear to be important serum biomarkers in predicting cardiac death in ESRD patients. Renal diseases cause inflammation, anemia, uremic toxins, fluid overload, and electrolyte disturbance. Kidney transplantation is considered the choice treatment for patients with ESRD. Ischemia-reperfusion (IR), which occurs during renal transplantation is one of the factors that affect the outcome of renal transplantation. Renal graft rejection is the result of IR injury and there is no effective treatment to prevent IR injury. Reperfusion after ischemia may cause injury through generation of reactive oxygen and nitrogen species, inflammatory responses by increased levels of tumor necrosis factor-α (TNF-α) and interleukins (IL), and apoptotic processes, and leads to acute kidney injury (AKI). Thus, antioxidant, anti-apoptotic and anti-inflammatory hormones, which inhibit these pathways, can protect against IR injury and improve transplanted renal function in patients with ESRD.
Plant Extract Mediated Synthesis of Nickel Oxide Nanoparticles

The present study reports the successful synthesis of nickel oxide nanoparticles using Vernonia amygdalina plant leaf extracts as a chelating agent and nickel (II) chloride hexahydrate (NiCl2•6H2O) as precursor. The synthesized powder was gray black in color and annealed at 500 °C for 2 hours to obtain nickel oxide nanoparticles. Characterization techniques such as powder X-ray diffraction, scanning electron microscopy, and Fourier transform infrared spectroscopy were used to study the structure and morphology of the nanoparticles. Powder X-ray diffraction patterns revealed that nickel oxide nanoparticles with an average crystallite size of 17.86nm were synthesized. Scanning electron microscope images show that the nanoparticles have octahedral structure. Fourier transform infrared spectrophotometer analysis revealed that the strongest bond at 1094.8cm-1 corresponds to stretching vibration mode of Ni-O nanoparticles.
Optimal Quality Control Based on Mascot and PTM Score Model for Phosphopeptides Identification

There are currently various algorithms with mass spectrometry in phosphorylation identification. Some quality control methods have also been proposed. However, a detailed comparative analysis among various methods has not been reported. In the paper, based on the theory of forward-reverse databases searching, we compare current major algorithms in database searching and identification i.e Mascot and Sequest, and compare various aspects and methods of algorithms in site assessment. We propose an effictive quality control method. Our result shows that this method can ensure the quality of identification and identify more phosphorylation sites.
A 1998 SOCIAL ACCOUNTING MATRIX (SAM) FOR THAILAND

This paper documents the features of a 1998 social accounting matrix (SAM) for Thailand. It begins with a description of the overall economy both via a macro SAM and a national accounts balance sheet. The macro SAM was the result of aggregating a micro SAM; a mapping of the final micro SAM to the macro SAM is presented. The micro SAM was a modified version of a SAM obtained from the Thai Development Research Institute (TDRI). The paper describes the modification process in detail. The original dataset obtained from TDRI was a "balanced™ matrix. " The converted SAM, after the modification, was still balanced. It was therefore unnecessary to apply any balancing procedure. The final 1998 micro SAM for Thailand has 61 sectors, 3 household types, and 3 factors (labor, agricultural capital, and non-agricultural capital). Particularly helpful for the intended analysis on energy and environmental policy is that it has 8 primary energy sectors, 5 transportation sectors, and a health and medical treatment commodity account.
Functional connectivity during feedback learning in smokers

Although it has been traditionally assumed that dysregulation of psychological processes in smokers results from activity within specific brain regions, an emerging view regards such dysregulation as attributable to aberrant communication between distinct brain regions. These processes can be measured during appropriate task paradigms such as the learning from errors task. This study aims to elucidate interactions between brain regions underlying the process of learning from errors, punishment and sensitivity to reward in dependent smokers.
Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors

A large number of inhibitory receptors recruit SHP1 and/or SHP2, tandem-SH2-containing phosphatases through phosphotyrosine-based motifs immunoreceptor tyrosine-based inhibitory motif (ITIM) and immunoreceptor tyrosine-based switch motif (ITSM). Despite the similarity, these receptors exhibit differential effector binding specificities, as exemplified by the immune checkpoint receptors PD-1 and BTLA, which preferentially recruit SHP2 and SHP1, respectively. The molecular basis by which structurally similar receptors discriminate SHP1 and SHP2 is unclear. Here, we provide evidence that human PD-1 and BTLA optimally bind to SHP1 and SHP2 via a bivalent, parallel mode that involves both SH2 domains of SHP1 or SHP2. PD-1 mainly uses its ITSM to prefer SHP2 over SHP1 via their C-terminal SH2 domains (cSH2): swapping SHP1-cSH2 with SHP2-cSH2 enabled PD-1:SHP1 association in T cells. In contrast, BTLA primarily utilizes its ITIM to prefer SHP1 over SHP2 via their N-terminal SH2 domains (nSH2). The ITIM of PD-1, however, appeared to be de-emphasized due to a glycine at pY+1 position. Substitution of this glycine with alanine, a residue conserved in BTLA and several SHP1-recruiting receptors, was sufficient to induce PD-1:SHP1 interaction in T cells. Finally, structural simulation and mutagenesis screening showed that SHP1 recruitment activity exhibits a bell-shaped dependence on the molecular volume of the pY+1 residue of ITIM. Collectively, we provide a molecular interpretation of the SHP1/SHP2-binding specificities of PD-1 and BTLA, with implications for the mechanisms of a large family of therapeutically relevant receptors.
Information seeking and health anxiety during the COVID‐19 pandemic: The mediating role of catastrophic cognitions

Abstract Cognitive–behavioural models of health anxiety propose a positive association between information seeking and health anxiety; however, it is unclear the extent to which cognitive mechanisms may mediate this relationship. Catastrophic cognitions are one type of cognition that may mediate this relationship, and the COVID‐19 pandemic has presented an opportunity to examine these relationships within the context of a global health catastrophe. The current study investigated both cross‐sectional (N = 797) and longitudinal (n = 395) relationships between information seeking, health anxiety and catastrophizing during the pandemic. Data were collected using Amazon Mechanical Turk during April and May 2020. Information seeking and health anxiety were positively associated both cross‐sectionally and longitudinally (rs = .25–.29). Catastrophic cognitions significantly mediated the relationship between information seeking and health anxiety both cross‐sectionally and longitudinally. Developing effective methods of reducing information seeking and catastrophizing may serve to reduce health anxiety during global health crises such as the current pandemic.
Study on the established customized limits for the daily quality assurance procedure

Abstract Since there are no corresponding specification limits for some new daily quality assurance (QA) items in the TG-142, it is a compromise that the specification limits used in the monthly or annual QA procedures are used for the daily QA procedure in work. But there is no basis for whether this is feasible. The purpose of this article is to analyze QA results using SPC to determine the tolerance limits at our institution, and to present the usefulness of the analysis method using SPC. The data of three groups daily QA processes performed with Daily QA3 in three years were analyzed using statistical process control (SPC). For calculating capability indices (Cp, Cpk, Cpm and Cpmk) of processes, the appropriate number of calculation points was analyzed firstly. Then, in calculating the capability indices for output, limits ±3% of the daily QA in the TG-142 were used as the specification limit, while for flatness and symmetry, an annual QA limits of ±1% was used. For putting forward measures to solve the problem, customized tolerance and action limits were established for each process. And the process control charts calculated using data measured by the five therapists and a medical physicist were compared. At least six to eight weeks of control daily check data points (i.e. 30–40 points) should be used for calculating the individuals and moving range (I-MR) control chart to ensure the stability of control lines. Process capability indices of output were all ≥1, some were up to 3–4. While for symmetry, some processes failed to meet the requirements that capability indices were < 1. For different processes of the same daily QA items, the calculated customized limits were quite different. The range of upper control line (UCL) and lower control line (LCL) was smaller for output and the CL was closer to the target value of 0 for flatness and symmetry in the I-MR control chart calculated using data measured by one staff. For different quality control processes without management by the SPC method at our institution, calculated tolerance and action limits of the same measurement item were quite different. And in most measurement items, the specification limits used in the monthly or annual QA procedures in the TG-142 are not suitable to the daily QA procedure. So the analysis method using SPC is useful and necessary.
Direct imaging of intraflagellar-transport turnarounds reveals that motors detach, diffuse, and reattach to opposite-direction trains

Significance Primary cilia are important organelles that exist in almost all eukaryotic cells. Intraflagellar transport (IFT) is a motor-protein–driven bidirectional intracellular transport mechanism in cilia. Previous studies have shown that motors in Caenorhabditis elegans chemosensory cilia undergo rapid turnarounds to effectively work together in driving orderly IFT. The mechanism of motor turnarounds has, however, remained unclear. Here, using a combination of advanced fluorescence imaging and single-molecule analysis, we directly show that the individual turnarounds are due to motors switching between opposite-direction IFT trains. Furthermore, we show that switching events consist of motors detaching from a train, diffusing to another one followed by attachment. This directly demonstrates that motors switch trains by diffusion, which clarifies the mechanism of motor turnarounds. Intraflagellar transport (IFT), a bidirectional intracellular transport mechanism in cilia, relies on the cooperation of kinesin-2 and IFT-dynein motors. In Caenorhabditis elegans chemosensory cilia, motors undergo rapid turnarounds to effectively work together in driving IFT. Here, we push the envelope of fluorescence imaging to obtain insight into the underlying mechanism of motor turnarounds. We developed an alternating dual-color imaging system that allows simultaneous single-molecule imaging of kinesin-II turnarounds and ensemble imaging of IFT trains. This approach allowed direct visualization of motor detachment and reattachment during turnarounds and accordingly demonstrated that the turnarounds are actually single-motor switching between opposite-direction IFT trains rather than the behaviors of motors moving independently of IFT trains. We further improved the time resolution of single-motor imaging up to 30 ms to zoom into motor turnarounds, revealing diffusion during motor turnarounds, which unveils the mechanism of motor switching trains: detach–diffuse–attach. The subsequent single-molecule analysis of turnarounds unveiled location-dependent diffusion coefficients and diffusion times for both kinesin-2 and IFT-dynein motors. From correlating the diffusion times with IFT train frequencies, we estimated that kinesins tend to attach to the next train passing in the opposite direction. IFT-dynein, however, diffuses longer and lets one or two trains pass before attaching. This might be a direct consequence of the lower diffusion coefficient of the larger IFT-dynein. Our results provide important insights into how motors can cooperate to drive intracellular transport.
Gestational stress alters maternal behavior and inflammatory markers in the olfactory bulb of lactating mice

Inflammatory markers represent important candidates responsible for the altered behavior and physiology observed after stressful experiences. In the maternal brain, the olfactory bulb (OB) is a key constituent of the neural circuit that mediates the reciprocal interaction between mother and infant. This study aimed to investigate the effects of stress during pregnancy on maternal behavior and inflammatory changes in the olfactory bulb of lactating mice. Female Balb/c mice were divided into two groups: control (CT) and restraint stress (RS). Maternal behavior was performed during the first 8 days of life of the offspring. On the 10th day after parturition, corticosterone, gene, and protein expression were assessed. Stress during pregnancy decreased the maternal index at postnatal day 4 and the nuclear factor‐κB 1 (NFκB1) gene expression in the OB. Moreover, females from the RS group showed increased interleukin (IL‐1β) protein expression. In contrast, stressed females exhibited a decreased tumor necrosis factor (TNF‐α) protein expression in the OB. In conclusion, exposure to stress during pregnancy was able to induce specific postnatal effects on maternal behavior and balance of inflammatory mediators in the OB.
Effects of Fear of Falling on the Single-Step Threshold for Lateral Balance Recovery in Older Women

Background and Purpose: Fear of falling is associated with poor physical health and influences postural stability during whole-body movement. The ability to recover from lateral balance loss is required to prevent falls; however, the relationship between lateral balance recovery and fear of falling has not been established. This study aimed to investigate whether fear of falling is associated with the stepping threshold for lateral balance recovery. Methods: This study included 56 ambulatory, community-dwelling women aged 65 years or older. We determined the single-step threshold as the maximum lean magnitude normalized with body weight from which participants could be suddenly released and still recover balance using a single side step. The short-form Falls Efficacy Scale International was used as a measure of fear of falling. Results and Discussion: The single-step threshold significantly correlated with age (rs =−0.603) and the short-form Falls Efficacy Scale International score (rs =−0.439). Ordinal regression analysis revealed that age (odds ratio, 0.826; 95% confidence interval, 0.742-0.920) and the short-form Falls Efficacy Scale International score (odds ratio, 0.811; 95% confidence interval, 0.680-0.966) were significantly associated with the single-step threshold, such that older age and greater fear of falling each independently predicted that failure to recover balance with a single step would occur at a lower percentage of body weight. Conclusions: Greater fear of falling was associated with reduced ability to recover from lateral balance loss in addition to aging. Future studies should explore whether evidence-based interventions to reduce fear of falling combined with perturbation training might lead to improved ability to recover from balance loss.
Body Image Distress and Its Associations From an International Sample of Men and Women Across the Adult Life Span: Web-Based Survey Study

Background Previous research on body image distress mainly relied on samples that were small, generally homogeneous in age or sex, often limited to one geographical region, and were characterized by a lack of comprehensive analysis of multiple psychosocial domains. The research presented in this paper extends the international literature using the results of the web-based Global Health and Wellbeing Survey 2015. The survey included a large sample of both men and women aged ≥16 years from Australia, Canada, New Zealand, the United Kingdom, or the United States. Objective The main objectives of this study are to examine body image distress across the adult life span (≥16 years) and sex and assess the association between body image distress and various psychosocial risk and protective factors. Methods Data were extracted from the Global Health and Wellbeing Survey 2015, a web-based international self-report survey with 10,765 respondents, and compared with previous web-based surveys conducted in 2009 and 2012. Results The body image distress of young Australians (aged 16-25 years) significantly rose by 33% from 2009 to 2015. In 2015, 75.19% (961/1278) of 16- to 25-year-old adults reported body image distress worldwide, and a decline in body image distress was noted with increasing age. More women reported higher levels of body image distress than men (1953/3338, 58.51% vs 853/2175, 39.22%). Sex, age, current dieting status, perception of weight, psychological distress, alcohol and other substance misuse, and well-being significantly explained 24% of the variance in body image distress in a linear regression (F15,4966=105.8; P<.001). Conclusions This study demonstrates the significant interplay between body image distress and psychosocial factors across age and sex.
Atrial fibrillation identification based on a deep transfer learning approach

Objective: Detection of Atrial fibrillation (AF); as a very common cardiac arrhythmia; is a challenging issue because it is often asymptotic. Most of previous studies were based on feature extraction or training CNNs from scratch. Difficulties in finding appropriate features, requiring an expertise for feature extraction and tuning parameters, and needs for a large amount of labeled data are the most drawbacks of previous studies. The transfer learning is a solution for these problems especially in the medical analysis where available data is limited. The main goal of this study is to investigate the ability of transfer learning method for classification ECG signals into normal, AF, other rhythms and noisy classes. Approach: In our analysis, ECG signals have been transformed to 6 s segments images and fed to three well-known pre-trained models (AlexNet, VGG-16, and ResNet-152). Features have been extracted from different layers of the models and used as the inputs of a classifier for AF detection. Then we have compared the best resulting model to proposed models trained from scratch. The proposed method also investigated the impact of models depth. The algorithms have been trained and validated using the public dataset of 2017 Physionet challenge. Main results: The method achieved average accuracy 87.9, and F-score 86.4 on the validation dataset (publicly available dataset). The second level of extracted features has the highest accuracy for all the pre-trained models in our study. Pre-trained AlexNet outperformed full training CNNs evaluated in this study. Significance: It is shown that the transfer learning method yields good accuracy recognition performance even when source and target datasets are completely different. The results show that the transfer learning is a reliable, accurate and low computational method to classify AF from short ECG signals while requires neither feature selection nor heavy processing steps.
Organizational Capability: Competing from the Inside Out

Changing Vistas for Management Thought. Forces for Change: The Call for Competitive Advantage. Competitive Advantage from the Inside Out through Organizational Capability. Creating Shared Mindset: Unity of Culture. Management Practices: Tools for Action. Generating Competencies: Selection and Development. Reinforcing Competencies: Appraisal and Rewards. Sustaining Competencies: Organization Design and Communication. Influence Management for the 1990a s. The Capacity for Change. Flexible Arrangements. Leadership. The Capable Organization: Key Questions and Principles. Epilogue: Reducing Potential Future Threat. Notes. Bibliography. Index.
Effect of Heat-Treatment Duration on Antioxidant Activities of Muscle, Liver and Other Parts of Grass Turtle (Chinemys reevesii)

Md. Serajul Islam1,2, Hongxin Wang1,2,*, Amer Ali Mahdi1, Mohamed Ismael Ahamed2, Zaixiang Lou1 and Fu An Wei3 1Food Nutrition and Functional Factors Research Center, School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi-214122, Jiangsu province, China 2State key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Jiangsu Province, China 3 Guangxi Zhongtaikang Technology Industry Co., Ltd., Nanning-530029, Guangxi, P.R. China Article Information Received 21 November 2019 Revised 22 July 2020 Accepted 05 March 2021 Available online 08 October 2021
Sword

Superior to 2,4-D on mustard, thistle, hoary cress (white top), poison hemlock, and hempnettle. Reduces Canada thistle competition more effectively than other phenoxies because SWORD can be applied earlier to wheat, barley or rye User-friendly, concentrated, formulation requires less product per acre, which reduces handling, mixing, freight costs and storage requirements Wide window of application extends application timing Compatible and easily tank mixed with many other herbicides, insecticides and liquid nitrogen solutions Rainfast in one hour
Kontrowersje wokół wystawy „Wymuszone drogi” na tle sporu o wypędzenia. Analiza debaty prasowej

The fact that controversies about the past become the subject of public debate testifies to the growing significance of the role of collective memory. In Poland two such controversies emerged recently. The first was triggered off by Jan Tomasz Gross’s book Neighbours that describes the murder committed during the war on Jews by the Polish inhabitants of Jedwabne; the other is a consequence of the actions taken up by the head of the Union of the Expelled, Erika Steinbach, and her many years’ endeavours to create the so-called Centre Against Expulsions in Germany. The matter of post-war “expulsions” divided Polish disputants into adherents of two opposed points of view. One thread of the debate that started in 2000 embraces controversies around the exhibition: “Enforced Roads. Escapes and Expulsions in 20th Century Europe” opened in August 2006 that commemorates the victims of expulsions. The article analyses the press debate around this exhibition in the context of the earlier stages of this controversy. It also describes the changes of relations between the main standpoints and their influence on the ideas of the past.