Miracle-dz/UniFAR-FTUs huggingface dataset:
TECH ULTRASONIC DROPLET GENERATOR 3 . 1 Operational Principles

A new printing technology based on ultrasonic actuation (~1 MHz) is presented that has the potential to print high viscosity fluids. In this paper, we describe the print-head’s operating principles and construction. Acoustic focusing in the nozzles produces high pressure gradients that help eject the fluid which, under the proper conditions, forms droplets. Two types of models are presented to attempt to predict print-head behavior over a range of conditions. The first model borrows from simple fully developed, laminar flows to estimate printing conditions based on fluid properties, as well as printing pressures. The second model captures the dynamic behavior of the print-head to estimate cavity resonances that lead to acoustic focusing and potentially droplet generation. We report on experiments with several types of fluids that demonstrate the technology’s potential.
Adult attachment styles, early relationships, antenatal attachment, and perceptions of infant temperament: A study of first-time mothers

We explored the relative contributions of first-time mothers’ romantic attachment styles and early relations with their own mothers to the prediction of infant temperamental difficulty. A mediating role for mother’s attachment to the unborn baby was assumed. In a prospective longitudinal study of 115 mothers of healthy babies, a structural model was delineated according to a conception of maternally reported infant temperament as a reflection of basic aspects of the mother’s personality and mother-infant relationships. Mothers’ experiences with their own mothers as supportive and nonintrusive differentiated between securely and insecurely attached participants. Security of attachment was found to facilitate antenatal attachment and perceptions of the 4-month-old infant as easier. Findings indicate that the effects of the mothers’ romantic attachment styles on their perceptions of temperamental difficulty are mediated by their antenatal attachment. Moreover, the pattern of findings obtained suggests a link among mothers’ history of relationships, romantic attachment styles, and caregiving characteristics that is congruent with evolutionary theoretical assumptions
Candidate Faces and Election Outcomes: Is the Face-Vote Correlation Caused by Candidate Selection? Corrigendum

We estimate the effect of candidate appearance on vote choice in congressional elections using an original survey instrument. Based on estimates of the facial competence of 972 congressional candidates, we show that in more competitive races the out-party tends to run candidates with higher quality faces. We estimate the direct effect of face on vote choice when controlling for the competitiveness of the contest and for individual partisanship. Combining survey data with our facial quality scores and a measure of contest competitiveness, we find a face quality effect for Senate challengers of about 4 points for independent voters and 1–3 points for partisans. While we estimate face effects that could potentially matter in close elections, we find that the challenging candidate's face is never the difference between a challenger and incumbent victory in all 99 Senate elections in our study.
Gaining A Deeper and More Accurate Understanding of Data Via Modern Robust Statistical Techniques

Many new and improved statistical techniques have been derived for comparing groups and studying associations. Under general conditions, compared to conventional methods based on means and least squares regression, these new methods provide more power, more accurate confidence intervals, and new perspectives that help deepen our understanding of data. Although it is well known in the statistics literature that these new methods can make a practical difference when analyzing data, it is evident that their practical advantages are not well known outside the group of statisticians who specialize in robust techniques. The paper reviews the basics of these new methods, including some recent advances, and it illustrates their practical advantages using data from various studies.
Smart policies or sheer luck ? Labour market resilience in the low countries

__Abstract__ This article explores the labour market resilience of Belgium and the Netherlands. We define labour market resilience as the capacity of labour markets to resist, withstand or quickly recover from negative exogenous shocks and disturbances and to renew, adjust or re-orientate in order to benefit from positive shocks. This article focuses on the labour market consequences of the crisis in these two countries and discusses their policy responses. Belgium and the Netherlands are often considered as comparable countries because of their open economies, their institutional characteristics and the fact that they usually are grouped together in the same welfare regimes. This article clearly shows that there are considerable differences between the countries. Although both countries have managed to limit the labour market consequences of the crisis, they have done so through the application of different interventions and reforms. From the comparison of these two countries we distillate more general conclusions about the factors that promote or limit labour market resilience.
New Chitosan/Poly(ethylene oxide)/Thyme Nanofiber Prepared by Electrospinning Method for Antimicrobial Wound Dressing

A new natural and environmental friendly wound dressing was introduced for the first time that was prepared by electrospinning method. This new wound dressing has chitosan base, and poly (ethylene oxide) was added as co-spinning agent to improve spinnability of chitosan. Moreover, thyme extract as a natural antibacterial additive was introduced in the as electrospun nanofibers scaffold in order to increase those wound healing properties. Some parameters of electrospinning such as feed rate, nozzle-collector distance, voltage and content of thyme extract in nanofiber structure were studied and optimized. The average diameters of prepared nanofibers was determined by “Clemex vision professional edition” software. Morphology and structure of electrospun nanofibers was studied with use of scaning electorn microscopy and Fourier transform infrared spectroscopy spectroscopy. The results showed that the antibacterial activity of nanofibers increased as the amount of thyme extract was increased, thus a chitosan/PEO containing 3% of thyme extract was selected as the best prepared nanofiber for wound dressing preparation. Chitosan/PEO/thyme nanofiber showed high stability in the buffer and good antibacterial activity against three understudy bacteria including Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus.
Influence of Subpixel-Scale Cloud-Top Structure on Reflectances from Overcast Stratiform Cloud Layers

Abstract Recent observational studies have shown that satellite retrievals of cloud optical depth based on plane-parallel model theory suffer from systematic biases that depend on viewing geometry, even when observations are restricted to overcast marine stratus layers, arguably the closest to plane parallel in nature. At moderate to low sun elevations, the plane-parallel model significantly overestimates the reflectance dependence on view angle in the forward-scattering direction but shows a similar dependence in the backscattering direction. Theoretical simulations are performed that show that the likely cause for this discrepancy is because the plane-parallel model assumption does not account for subpixel-scale variations in cloud-top height (i.e., “cloud bumps”). Monte Carlo simulations comparing 1D model radiances to radiances from overcast cloud fields with 1) cloud-top height variations but constant cloud volume extinction, 2) flat tops but horizontal variations in cloud volume extinction, and 3) v.
Modeling bobcat Lynx rufus habitat associations using telemetry locations and citizen-scientist observations: are the results comparable?

To understand large scale animal—habitat associations, biologists often rely on intensive home-range based studies, where a large number of locations are obtained from relatively few individuals equipped with radio transmitters and then extrapolate patterns of habitat use to much larger areas. Alternatively, extensive methods (e.g. incidental observations) that provide few observations per individual can be effectively used to sample large areas. Both methods have advantages, limitations, and potential sources of bias. We used these different approaches in an effort to identify habitat features that may be important to expanding populations of bobcats Lynx rufus in New Hampshire, USA. Twelve adult bobcats with GPS-equipped transmitters provided detailed summaries of movement patterns within a 2300-km2 study area. We also solicited incidental observations from citizens throughout the state (24 200 km2). Using locations from both methods, we developed logistic models based on a comparison of home range composition to study area composition (second-order habitat selection). We also explored an approach to reduce potential bias associated with incidental observations (overrepresentation of human population centers) by applying a weighing factor. The telemetry and uncorrected observation-based models overlapped substantially with eight common covariates. The telemetry-based model indicated that bobcats preferred areas with few roads, limited human development, high stream densities, and steep topography. In contrast, the adjusted (to reduce bias) observation-based model indicated bobcats preferred areas with an abundance of roads and development with few streams and limited topographic variation. Because of these differences, we recommend caution when using sightings to model habitat associations unless biases associated with such information can be identified and overcome. Although public sightings had limited application for describing bobcat habitat, they were useful in documenting a recent range expansion and revealing novel prey use by bobcats.
Cercamia melanogaster , a new species of cardinalfish ( Apogonidae ) from West Papua , Indonesia

A new species of apogonid, Cercamia melanogaster, is described from 11 specimens, 17.1–28.0 mm SL, collected in 15–42 m in the Bird’s Head region of West Papua Province, Indonesia. Diagnostic features include dorsal rays VI-I,9; anal rays II,11–13; pectoral rays 9–11; gill rakers 1 + 10–12; scales cycloid, about 22–23 in lateral series and 9–10 in transverse series; scales present on preopercle and opercle; colour overall transparent pinkish with broad red zone on side of snout to rear margin of head, red on ventralmost part of head, and dark brown (nearly black) abdomen with diagonal pearly white band from upper rear margin of operculum to vent. Genetic evidence is provided to show a high level of divergence in the mtDNA COI marker between the three recognized species in Cercamia, including the new taxon, C. cladara, and C. eremia.
Photonic nonlinear delay dynamics for advanced information processing : from secure chaos communications to brain-inspired computing

Photonics is a priviledged playground for the investigation of the dynamical complexity exhibited by delay equations. In this particular field of Physics, these infi nite dimensional dynamics become tractable, controllable , and can be experimentally explored under a wide set of parameter settings. Beyond the fundamental and theoretical interest aimed at the understanding of their numerous dynamical mechanisms, photonic even provides opportunities to exploit this dynamical complexity for advanced information processing principles. In this contribution, we wil l review two such applications implemented in photonic, optical chaos communication, and Reservoir Computing.
Cross-Site Virtual Network Provisioning in Cloud and Fog Computing

ion and Simplicity The configuration and instantiation methods of virtual networks spanning different fog and cloud sites should be independent of the technologies offered by the different cloud providers and fog infrastructures. The users should not be aware of how these virtual networks are configured in terms of network elements (e.g. switches, routers or VPN gateways) and technologies (e.g. tunnels or encapsulation techniques). These configuration and instantiation methods should be simple, to allow the deployment and operation of complex networking scenarios. Heterogeneity The HFC interconnection framework should enable application tenants to deploy a virtual network spanning heterogeneous fog infrastructures and clouds, which use different technologies and are managed by different fog/cloud
Morphostructural Differentiation and Variability of Merino Sheep Breed Under Sustained Directional Selection

En el presente trabajo se analiza el grado de diferenciacion y variabilidad morfoestructural alcanzado por el tipo de animal resultante de una seleccion direccional sostenida y sus implicancias en la emergencia de un nuevo grupo racial ovino. Se midieron 25 machos y 200 ovejas adultas. Se tomaron 13 medidas corporales, evaluando la diferenciacion de la morfologia estructural y el dimorfismo sexual. Estas mediciones se compararon con las realizadas en animales de raza Merino Australiano y Marin Magellan Meat Merino. La homogeneidad intrapoblacional se evaluo a traves de los coeficientes de variacion porcentual de las medias de las medidas corporales. Se concluye que la seleccion direccional realizada de forma sostenida ha generado una diferenciacion del formato morfoestructural al comparar a la poblacion sujeta a seleccion con las principales raza de tipo Merino existentes en la Patagonia Chilena. La poblacion evaluada evidencia una variabilidad morfoestructural similar, y en muchos casos menor a la encontrada en razas ovinas reconocidas como tales en Chile, con lo cual es posible senalar que se comporta como un grupo animal distinguible con caracteres de raza.
Polyphenolic Content and Antioxidant Capacity of White, Green, Black, and Herbal teas: a Kinetic Study

Camellia sinensis teas, and tisanes derived from herbs or fruit, are rich in polyphenolic, antioxidant compounds. This study compared the total phenolic content (TPC), total flavonoid content (TFC), ferric reducing antioxidant power (FRAP), DPPH radical scavenging capacity, and caffeine content of teas (black, green, white, chamomile, and mixed berry/hibiscus) over a range of infusion times (0.5–10 mins) at 90°C. Green, followed by black tea, respectively, had the greatest TPC (557.58 and 499.19μg GAE/g), TFC (367.84 and 325.18μg QE/g), FRAP (887.38 and 209.38μg TE/g), and DPPH radical scavenging capacity (1233.03 and 866.39μg AAE/g). Caffeine content per cup (200mL) in black, green, and white tea was 63, 51, and 49mg respectively. Changes in the phenolic content and antioxidant capacity of teas were modelled using zero, first, and fractional-conversion-first-order (FCFO) kinetic models. Results fitted a FCFO kinetic model, providing useful data for maximum phytochemical preservation in the optimisation of industrial and domestic processing. As a dietary comparison, green, black, and white tea were found to have a greater phenolic content and antioxidant capacity than fresh orange and apple juice. It can be concluded that green and black teas are significant sources of dietary phenolic antioxidants.
The Significance of Soluble Molecules of Cellular Adhesion, Nitric Oxide Metabolites, and Endothelin-1 and Their Associations as Markers of Progression of Inflammation in COPD

N.I. Kubysheva, DSc, Senior Researcher, Research Laboratory “Medical Informatics”, Higher School of Information Technologies and Information Systems1; L.B. Postnikova, MD, DSc, Professor, Pulmonary Physician2; S.K. Soodaeva, MD, DSc, Professor, Head of the Laboratory of Clinical and Experimental Biophysics3; Professor, Department of Human Pathology, Institute of Professional Education4; V.V. Novikov, DSc, Professor, Director, Research Center for Molecular Biology and Biomedicine5; S.V. Shumilova, PhD, Researcher, Research Center for Molecular Biology and Biomedicine5; E.S. Kasatova, PhD, Senior Researcher, Research Center for Molecular Biology and Biomedicine5; Т. I. Eliseeva, MD, DSc, Associate Professor, Department of Hospital Pediatrics6; S.K. Ignatov, DSc, Professor, Department of Photochemistry and Spectroscopy5; T.V. Li, MD, PhD, Neurologist, Center for Neurology and Rehabilitation7; I.Z. Batyrshin, DSc, Professor, Research Computing Center8
Helping Parents With Chores or Going Out With Friends: Cultural Differences in Adolescents’ Responses to Potentially Conflicting Expectations of Parents and Peers

The study examined cultural similarities and differences in how adolescents deal with conflicting expectations of parents and peers. It was tested to what extent adolescents’ interdependence values and satisfaction with family and friendships predict the way they would solve the disagreement, where they had planned to go out with friends, but their parents wanted them to stay at home to do chores. Moreover, adolescents’ reasons for their reported actions were examined. The sample included 894 Estonian, German, and Russian adolescents (M age around 15 years). Russian adolescents were more likely than their Estonian and German peers to comply with parents’ requests. This was possibly due to interdependence values being more important for them. Satisfaction with family relationships and friendships was not linked to adolescents’ compliance. Adolescents from all cultures were similar in terms of suggesting self-oriented reasons for noncompliance, while Estonian and German adolescents expressed their need for autonomy more explicitly. Russian adolescents were, however, more oriented to maintaining good relationships with parents and friends, respectively, in their reasons for compliance and noncompliance. They were also less likely to suggest compromise.
Enhancing adipose stem cell chondrogenesis: A study on the roles of dexamethasone, transforming growth factor β3 and ascorbate supplements and their combination

AC: Articular Cartilage; ACAN: Aggrecan; ACTE: Articular Cartilage Tissue Engineering; ALP: Alkaline Phosphatase; ADSC: Adipose derived Mesenchymal Stem Cell; Asc: Ascorbate; BMP: Bone Morphogenic Protein; BMSC: Bone Marrow derived Mesenchymal Stem Cell; CF: Chondrogenic factor; Col: Collagen; Dex: Dexamethasone; DTA: Dex with Asc and TGF-β; DT: Dex with TGF-β3; ECM: Extracellular Matrix; FGF: Fibroblast Growth Factor; GAG: Glycosaminoglycans; GF: Growth Factor; h: human; IGF: Insulin like Growth Factor; MMP: Matrix Metallopeptidase; MSC: Mesenchymal Stem Cell; OA: Osteoarthritis; RUNX2: Runt-related transcription factor 2; SC: Stem Cell; TE: Tissue Engineering; TGF-β: Transforming Growth Factor -β; VEGF: Vascular Endothelial Growth Factor; wrt: with respect to;
High Mechanical Performance Composite Conductor: Multi‐Walled Carbon Nanotube Sheet/Bismaleimide Nanocomposites

Multi‐walled carbon nanotube (MWNT)‐sheet‐reinforced bismaleimide (BMI) resin nanocomposites with high concentrations (∼60 wt%) of aligned MWNTs are successfully fabricated. Applying simple mechanical stretching and prepregging (pre‐resin impregnation) processes on initially randomly dispersed, commercially available sheets of millimeter‐long MWNTs leads to substantial alignment enhancement, good dispersion, and high packing density of nanotubes in the resultant nanocomposites. The tensile strength and Young's modulus of the nanocomposites reaches 2 088 MPa and 169 GPa, respectively, which are very high experimental results and comparable to the state‐of‐the‐art unidirectional IM7 carbon‐fiber‐reinforced composites for high‐performance structural applications. The nanocomposites demonstrate unprecedentedly high electrical conductivity of 5 500 S cm−1 along the alignment direction. Such unique integration of high mechanical properties and electrical conductance opens the door for developing polymeric composite conductors and eventually structural composites with multifunctionalities. New fracture morphology and failure modes due to self‐assembly and spreading of MWNT bundles are also observed.
ALS-RELATED FUS PROTEIN IS MISLOCALIZED TO CYTOPLASM AND RECRUITED INTO STRESS GRANULES IN FIBROBLASTS OF ASYMPTOMATIC FUS P 525 L MUTATION CARRIERS

4 INTRODUCTION . 6 1. Amyotrophic Lateral Sclerosis . 7 2. Fused in Sarcoma (Fus) . 12 3. Fused in Sarcoma (Fus) and Stress Granules . 16 RESEARCH OBJECTIVES . 18 SUBJECTS, MATERIALS AND METHODS . 20 1. Subjects. 21 2. Skin biopsy and Human Fibroblasts Culture . 23 3. Stress induction . 24 4. Subcellular Fractionation . 25 5. SDS-page and Western blotting . 26 6. Immunofluorescence . 27 7. Cell counting and subcellular FUS expression. 28 8. Evaluation of the number cells containing stress granules . 29 9. Evaluation of the number of stress granules per cell . 29 10. Data analysis and statistics . 30 RESULTS . 31 1. FUS is mislocalized to cytoplasm in cells of asymptomatic FUS P525L mutation carriers. 33 2. Cellular stress induces cytoplasmic FUS recruitment into stress granules. 38 3. Cell viability and proliferation after stress induction . 41 4. Long persistence of the stress granules in the cytoplasm of FUS P525L fibroblasts . 42 DISCUSSION . 46 FINAL CONCLUTIONS AND FUTURE PROSPECTS . 52 REFERENCES . 55
Systems Biology of the Secondary Metabolism in Filamentous Fungi

Filamentous fungi constitute a rich reservoir of pharmaceutically relevant bioactive small molecules. These compounds, commonly referred to as secondary metabolites, are widely used as antibiotics for the treatment of microbial infections, but also as other pharmaceuticals such as immunosuppressors, cholesterol lowering agents and anticancer drugs. Although fungal derived antibiotics have been known for almost a century, genome sequencing has revealed that the biosynthetic potential of fungi is not fully exhausted. The Penicillium genus consists of around 350 accepted species, and many of these are well-known producers of pharmaceuticals and industrially exploited for this. The genus as a whole, however, is grossly understudied at the genomic level. To assess the potential for secondary metabolite biosynthesis in the Penicillium genus, we sequenced the genomes of ten species that produce diverse arrays of secondary metabolites in culture. One of the sequenced isolates was described as a new species, and we mapped secondary metabolites detected in culture to the corresponding biosynthetic gene clusters. The ten sequenced genomes were analyzed together with published Penicillium genomes, altogether 24, and we developed a pipeline to group biosynthetic gene clusters and map them to known pathways. We found a large untapped potential for biosynthesis of secondary metabolites, encoded in the genomes of these species, that potentially could fill the drug discovery pipeline. Based on our predictions, we experimentally identified a novel compound from the antifungal class of antibiotics called yanuthones. Since heterologous expression of secondary metabolite pathways has proved troublesome, the ten genome-sequenced Penicillium species were evaluated as cell factories in controlled bioreactor fermentations. Compared to an industrially relevant strain, the ten Penicillium species showed growth characteristics that encourage further exploration of their industrial potential. Transcriptome analysis of six of the species enabled the identification of a metabolic network that is responsible for precursor formation of secondary metabolites. This network provides important insight into the further industrial development of Penicillium cell factories, and could be used in designing metabolic engineering strategies for optimization of secondary metabolite production. Altogether this thesis provides novel insights into genetic and metabolic aspects of fungal secondary metabolism. Our findings propose that industrial production of secondary metabolites can be effectively established on the basis of native producers. Penicillium species constitute a rich source of drug leads, and possess promising physiological characteristics to be established as industrial production platforms.