Miracle-dz/UniFAR-FTUs huggingface dataset:
Inhibitory Effects of Doxycycline on Tumor Progression In vitro and on Metastases in Early-Stage Osteosarcoma Xenografts Mice.

BackgroundOsteosarcoma (OS) is the commonest primary osseous malignant tumor with a high propensity to metastasize in lungs. Pulmonary widespread micrometastatic lesions are present in up to 80% of patients at initial diagnosis and they are associated with significantly worse prognosis. Doxycycline (Dox) is a synthetic tetracycline that has been shown to have anti-cancer properties in vitro and in vivo, and inhibit angiogenesis, effects that may prove beneficial for several types of cancer. The aim of the present work was to study how Dox affects OS cells’ growth in vitro and in vivo and OS-driven pulmonary metastasis in vivo. Methods In vitro, the effect of Dox was measured in MG-63 and 143B human OS cells’ viability, apoptosis, and migration. In vivo, highly metastatic143B cells were orthotopically implanted into the tibia of SCID mice and tumor growth as well as pulmonary metastases between Dox treated and untreated, non-amputated and early amputated xenografts were examined. ResultsDox decreased the viability, inhibited the migration, and induced the apoptosis of OS cells in vitro. In vivo, Dox significantly enhanced tumor necrosis at primary OS sites, similarly to its in vitro effect. It also decreased the expression of Ki67, metalloproteinases 2 and 9 (MMP2 and MMP9), vascular endothelial growth factor A (VEGFA) and Ezrin in primary tumors. It also decreased the circulating VEGFA and MMP9 protein levels, in line with the decreased metastatic burden in Dox-treated mice in both non-amputated and early amputated xenografts.ConclusionsOur results suggest that adjuvant administration of Dox may decrease OS growth and development of pulmonary metastases. Administration of Dox in combination with surgical resection and standard chemotherapeutic protocols in the early-stages of OS treatment is also supported. Moreover, Dox administration prior to the development of clinically detectable pulmonary macrometastases, is associated with enhanced clinically benefits from its anti-metastatic effect.
EXCESSIVE GROWTH OF FENNEL PONDWEED (Stuckenia pectinata) IN THE KIZILIRMAK RIVER, CAPPADOCIA, TURKEY

An excessive growth of submerged vegetation has been observed in some regions of the Kızılırmak river. In this research, conducted below Yamula Dam, monthly changes in submerged macrophytes in the river course around Avanos (Nevsehir) were investigated. Submerged plant samples were taken from four stations and some water quality parameters were measured. The submerged plant which had increased excessively was identified as fennel pondweed, Stuckenia pectinata (L.) Börner. Molecular identification using a partial sequence of the ITS region has found that sampled S. pectinata specimens were not closer to sequences belonging to hybrid samples. Rather, nucleotide sequences of analysed fragment of ITS region have shown that the phytogeographic distribution of the haplotype, lies between eastern and western examples. The mean submerged plant biomass was estimated as 721 ± 288 g dry weight/m in the research period. The excessive increase of S. pectinata in the Kızılırmak can be attributed to the regulated flow in the river, and its salt tolerance and preference for hard waters. Since it was the single dominant species of submerged macrophyte in the study area, macrophytes indices could not be applied. Mechanical/physical control was recommended for the control of submerged plant biomass in the area.
Effect of service quality on post-visit intentions over time: The case of a library

The quality of services offered in an academic library has been investigated over a period of time. Attribute level service quality, importance, satisfaction and post-visit intentions have been measured twice during a period of six months. The study indicates that the service quality has fallen during the six-month period in the case of most attributes while the attribute importance levels have not changed significantly during the same period. The temporal effect of service quality on post-visit intentions has been examined in a causal path framework. The results indicate that service quality and resulting satisfaction levels during the intervening period modify the effect of service performance and satisfaction on future post-visit intentions.
Data Reverse Engineering : Slaying the Legacy Dragon

Part 1 DRE context: DRE defined DRE's role in enterprise integration data architectures in organizational strategy developing a DRE framework. Part 2 Investing in DRE projects: understanding the challenges and critical success factors DRE performance teams estimating DRE projects identifying and evaluating DRE opportunities. Part 3 DRE analysis and outputs: project initiation and management analyzing the target system tool support primary project outputs secondary outputs (data integration, business rules, data evolution, data exchange) trends and research in DRE.
Nano-Hydroxyapatite Gel and Its Effects on Remineralization of Artificial Carious Lesions

Introduction Nano-hydroxyapatite gel (NHG) has never been investigated for enamel remineralization. This study evaluated the effects of two concentrations of NHG on remineralization of an artificial carious lesion in comparison with nano-HA toothpaste (NHT) and fluoride varnish (FV). Materials and Methods Carious lesions were prepared on 100 enamel samples and divided into 5 groups: FV, NHT, 20% NHG, and 30% NHG. One untreated (NT) group was left as control. The hardness of the surface was evaluated before, during, and after remineralization. Microhardness at various phases and the percent recovery of hardness (%HR) were determined and analyzed with ANOVA. Polarized-light micrographs (PLM) were evaluated for depth of the carious lesion. Results Significantly different remineralization capability was indicated for tested agents (p < 0.05). NHT was significantly capable of remineralization greater than NHG, FV, and NT (p < 0.05). No noticeable difference in %HR between 20% NHG and 30% NHG (p > 0.05) was found. Decreasing in the depth of caries lesion was notified by PLM as applying either NHT or NHG as greater than FV, with no reduction in the depth for NT. Conclusions Nano-HA both in toothpaste and gel form was capable of remineralization better than fluoride varnish. Comparable remineralization of 20% versus 30% NHG was evidenced. NHG for both concentrations was recommended as a capable remineralizing agent for caries remineralization. Clinical Significance: This study indicated that an application of nano-HA gel is an attractive route to deliver the material and can be more effective and less toxic than conventional formulations and provide its effectiveness directly at the site of action, especially for a noncooperative young child and medicinally intimidated patients who may face with inconvenience in using toothbrush and toothpaste for hygiene control.
Fabrication and characterization of porous metal emitters for electrospray applications

Electrospray thrusters provide small, precise thrust with high power efficiencies and variable specific impulses from less than 1000s to over 4000s. The miniaturization and clustering of many emitters together is essential to increase the thrust density of electrospray devices in order to increase their domain of applicability in space. Electrospray emitter arrays have many advantages over existing electric propulsion devices including much lower mass per unit thrust and much lower volume per unit thrust than conventional ion and hall devices. Additionally, with emitter clustering, the thrust density can meet and even exceed that of hall or ion thrusters. A method of micro-fabricating electrospray emitter arrays using modified conventional microfabrication technology is presented. The method is adaptable to different emitter materials and can be used to create ultra dense emitter arrays with microfabrication precision down to the micron level. One-dimensional linear emitter arrays with emitter separation as low as 500 /Lm have been fabricated out of porous tungsten and preliminary tests show that dense two-dimensional emitter arrays can be fabricated with emitter separations down to 300am. Experimental research that was conducted to characterize emitter array performance is also presented. Time of flight mass spectrometry was used to identify the emitted ion species from the device, which showed that the device operates in the ion emission regime. Current was collected as a function of applied voltage to show that the devices were able to operate with emitted current levels of 0.5 1.5 YA per emitter, even for dense arrays. Direct thrust measurements were performed to show that the amount of thrust attainable is on the order of 0.1 pN per MA of emitted current for extraction voltages of around 1900 V. A normalization scheme was implemented to compare performance of emitter arrays of different density and initial results from a numerical model has shown that the emitters might be limited by fluid transport. Thesis Supervisor: Prof. Paulo C. Lozano Title: Assistant Professor
Hybrid node for description of thin wires based on analytical field representation in EMC problems

This paper describes a novel formulation for the description of thin wires in coarse numerical models. The approach is based upon exact field expansions around a thin wire which are then interfaced with the numerical algorithm; here the transmission line modeling (TLM) numerical method is used The new formulation yields a robust, accurate and stable simulation method that allows for variable wire radii and arbitrary positioning within numerical cells without the use of empirical factors. Significantly, it also does not incur additional overhead in terms of hardware or simulation run time. Numerical examples are given which indicate the suitability of the method for application in Electromagnetic Compatibility (EMC) problems.
High efficient upconversion luminescence of NaGdF4: Yb3+/Er3+ nanoparticle: first-principles calculation, dual-wavelength stimuli and logic gate application

ABSTRACT First-principle theory was used to design NaGdF4:Yb3+/Er3+ crystal, where the density of state, X-ray diffraction and optical coefficient had been studied through a generalised gradient approximation within density functional theory to predicate the effect of rare earth ion doping on the electronic and optical performance. Besides, NaGdF4:Yb3+/Er3+ nanoparticles were also obtained by liquid–solid–solution method and realized the enhancement of upconversion emission and the regulation of spectrum under co-excitation of the 980 nm and 1550 nm lasers. The results inspired us to establish upconversion logic gate system, where ‘INHIBIT, OR, XOR, YES, AND’ logic gate operations had been successfully developed by introducing external two excitation sources as input signals and monitoring the relative intensity signals of green and red emission bands and G/R ratio signal.
Estimation of the prevalence of diabetes and study of some socio-demographic determinants among the diabetic population in Salé, Morocco-2021

According to the World Health Organization, diabetes is the cause of 1.5 million deaths each year, 80% of which occur in low- and middle-income countries. It will become the principal cause of death by 2030. In Morocco, the situation is as alarming as at the global level. However, the prevalence of diabetes at the provincial level is unknown. This paper aims to present partial results obtained from a statistical study, carried out in February 2021, where we estimated the prevalence of diabetes and studied some socio-demographic determinants among the diabetic population living in Salé, Morocco. The investigation included a sample of 488 households selected according to a two-stage stratified probabilistic sampling plan (466 of which were surveyed (i.e. 1868 individuals) with a response rate of 466/488 =95.5%). The results showed that, in 2021, diabetes was affecting 5.5% (95% CI 4.5%, 6.6%) of the studied population (5.8% of women and 5.1% of men, 5.6% in urban areas and 4.5% in rural areas). The proportion of diabetics increases significantly with age (p-value=0.0001<0.05). It was 0.1% among young people (<18 years), 3.9% among individuals aged 18-59, and 26.9% among those aged 60 and above. A logistic model, making it possible to predict, with an accuracy of 91.7%, the risk of contracting diabetes among the population aged 18 and above (1,308 subjects, 7.8% of which were diabetic), was performed. The model included several socio-demographic determinants. Age, educational level, economic activity, average household income and smoking were significantly associated with diabetes.
Tactical missile conceptual design.

Abstract : This thesis presents the theory necessary for the conceptual design of a tactical missile. The design process begins with the well known linear aerodynamic theory for initial sizing and later includes nonlinear effects to determine the final design of the missile. Where theory does not apply, empirical methods are presented which are known to give accurate results. An air-to-air missile is designed for a specific threat as an example which immediately follows the development of the theory for each section. Several small digital computer programs are presented and used for analysis of specific areas of the design. One large program (AEROL) is used for determining the aerodynamic coefficients of the final design. (Author)
Association between hospital treatment volume and survival of women with gynecologic malignancy in Japan: a JSOG tumor registry-based data extraction study

Objective Associations between hospital treatment volume and survival outcomes for women with 3 types of gynecologic malignancies, and the trends and contributing factors for high-volume centers were examined. Methods The Japan Society of Obstetrics and Gynecology tumor registry databased retrospective study examined 206,845 women with 80,741, 73,647, and 52,457 of endometrial, cervical, and ovarian tumor, respectively, who underwent primary treatment in Japan between 2004 and 2015. Associations between the annual treatment volume and overall survival (OS) for each tumor type were examined using a multivariable Cox proportional hazards model with restricted cubic splines. Institutions were categorized into 3 groups (low-, moderate-, and high-volume centers) based on hazard risks. Results Hazard ratio (HR) for OS each the 3 tumors decreased with hospital treatment volume. The cut-off points of treatment volume were defined for high- (≥50, ≥51, and ≥27), moderate- (20–49, 20–50, and 17–26), and low-volume centers (≤19, ≤19, and ≤16) by cases/year for endometrial, cervical, and ovarian tumors, respectively. Multivariate analysis revealed younger age, rare tumor histology, and initial surgical management as contributing factors for women at high-volume centers (all, p<0.001). The proportion of high-volume center treatments decreased, whereas low-volume center treatments increased (all p<0.001). Treatment at high-volume centers improved OS than that at other centers (adjusted HR [aHR]=0.83, 95% confidence interval [CI]=0.78–0.88; aHR=0.78, 95% CI=0.75–0.83; and aHR=0.90, 95% CI=0.86–0.95 for endometrial, cervical, and ovarian tumors). Conclusion Hospital treatment volume impacted survival outcomes. Treatments at high-volume centers conferred survival benefits for women with gynecologic malignancies. The proportion of treatments at high-volume centers have been decreasing recently.
Characterization of ruminal acidosis and initial phase of laminitis inducted by oligofructose in crossbred calves

ABSTRACT: One of the ways to study cattle laminitis is its experimental induction by supplying a large amount of high fermentation carbohydrate. The most effective protocol until now has been the use of oligofructose. The objective of this study was to evaluate clinical and histological aspects of the hoof in experimental induction of ruminal acidosis and laminitis in calves using oligofructose. Six crossbred (Bos taurus x Bos indicus) yearling calves divided into Group I (GI) and Group II (GII) were used. Animals in GI and GII received intraruminal oligofructose in doses of 13 and 17g/kg, respectively. During 28 hours the calves were clinically evaluated and 30 hours after induction, samples were taken from coronary and abaxial wall of the hoof for histologic evaluation. Were noticed signs of ruminal and metabolic acidosis like rumen distension with fluid, diarrhea, ruminal pH reduction and, at blood gas analysis, pH and bicarbonate below reference range. Lameness was not observed however, some animals had a slower gait and apathy, possibly due to metabolic acidosis, though. Histologically, typical lesions of laminitis like circulatory changes and inflammatory infiltrate in the dermis, irregularities and areas of detachment at basement membrane and morphologic changes in cells from basal epidermis were found. The protocol induced, in the first 30 hours, clinical signs of ruminal and metabolic acidosis and low grade histologic lesions in the digits. Lameness and digit pain were not observed, characterizing the prodromic phase of the disease.
Status and specifications of a Project X front-end accelerator test facility at Fermilab

This paper describes the construction and operational status of an accelerator test facility for Project X. The purpose of this facility is for Project X component development activities that benefit from beam tests and any development activities that require 325 MHz or 650 MHz RF power. It presently includes an H- beam line, a 325 MHz superconducting cavity test facility, a 325 MHz (pulsed) RF power source, and a 650 MHz (CW) RF power source. The paper also discusses some specific Project X components that will be tested in the facility.
The environmental and cost impacts of vehicle electrification in the Azores

Electric vehicles (EVs) have the potential to reduce transportation sector CO2 emissions in Sao Miguel, an island in the Azores, while simultaneously reducing mobility operating costs. This thesis attempts to quantify the cost and environmental impacts of using EVs on Sao Miguel, using an economic dispatch and unit commitment model. The number of EVs and the ways that they charge are varied. The composition of Sao Miguel’s electric power generation portfolio is varied from its current composition to one that incorporates higher levels of renewable generation. Emissions reductions stemming from EVs vary according to how the vehicles are charged and when renewable generation, which is less expensive and less CO2intensive than thermal generation, is available. Charging “optimally” can save hundreds of thousands of Euros in system mobility costs per week and, in some cases, halve transportation CO2 emissions. Optimal charging results also show that, in certain cases, charging during periods of high electric demand is acceptable. This result is contrary to previous literature on vehicle charging, and is due primarily to the limited number of generators on Sao Miguel. CO2 abatement costs stemming from the use of EVs vary from 26 to 160 Euros per tonne of CO2. Portugal’s tax on gasoline and subsidization of EVs make calculating the exact cost of EVs in Sao Miguel difficult, but a simple discounted cash flow shows that, for a 950 electric vehicle fleet, the internal rate of return over a ten year period is 8.24%. Other costs associated with EVs, including the installation of new grid infrastructure and charging stations, are also considered. Thesis Supervisor: Stephen Connors Title: Director, Analysis Group for Regional Energy Alternatives Thesis Supervisor: Ignacio J. Perez-Arriaga Title: Visiting Professor, Engineering Systems Division Professor of Electrical Engineering, Universidad Pontificia Comillas, Madrid, Spain
Grand Societal Challenges and Responsible Innovation

Grand societal challenges (GSCs) represent complex, multi-level, multi-dimensional problems that require concerted efforts by various actors - public, private, and non-profit - to be successfully addressed. Businesses - alone or in conjunction with governmental and non-profit organizations - are relevant actors in this regard, as they represent a source of innovation. Responsible innovation (RI) is a framework that allows for the governance and evaluation of innovations with regard to their potential harmful consequences and positive contributions to societal challenges. Moreover, it stipulates that this evaluation process should be facilitated by appropriate governance structures at various levels. The aim of this article is to expand theorizing on GSCs and RI and to encourage research that explores their links. We outline pertinent characteristics of GSCs that make current conceptualizations of corporate social responsibility and social innovation limited in addressing GSCs. We explicate the reflexive and participative capacities of RI governance as a complementary and promising way forward. Finally, we introduce the contributions to this Special Issue as illustrations of relevant theoretical and empirical groundwork around GSCs and RI, and outline the agenda for future research.
Industry perspectives on reusable launch vehicle technicians

Vlasman, Brent A. M.S., Purdue University, May, 2010. Industry Perspectives on Reusable Launch Vehicle Technicians. Major Professor: David Stanley. Companies in the commercial space industry are developing a new generation of reusable launch vehicles (RLV). The Federal Aviation Administration’s Office of Commercial Space Transportation (FAA/AST) is working on creating a new generation of technicians, the RLV Aerospace Maintenance Technician (RAMT), who is capable of maintaining these new vehicles. However, the FAA/AST does not yet know the knowledge required of this technician in order to maintain this new vehicle type. This exploratory, qualitative study examined the subject area knowledge required of reusable launch vehicle technicians in the United States’ sub-orbital commercial space industry. The study sought to answer the question, “What are important subject areas for the training of RLV technicians? ” This was accomplished by interviewing subject matter experts from the companies developing sub-orbital RLVs over the telephone. The interviews were recorded, transcribed, and then analyzed for common themes using Strauss and Corbin’s Grounded Theory, qualitative content analysis, and cross case analysis. This study found that important subject areas for the training of RLV technicians include: Rocket Propulsion, Aviation Maintenance, Electronics/Electrical Systems, Mechanical Systems, Engineering, Project Management, and Aerodynamics. Recommendations are made to develop an RLV curriculum based on these subject areas as a supplemental area of study for aviation maintenance training programs.