Miracle-dz/UniFAR-FTUs huggingface dataset:
Neural Correlates of Autobiographical Memory: Evidence From a Positron Emission Tomography Study in Patients With Mild Cognitive Impairment and Alzheimer's Disease

Background: Autobiographical memory (AM) changes are the hallmark of Alzheimer's disease (AD) and mild cognitive impairment (MCI). In recent neuroimaging studies, AM changes have been associated with numerous cerebral sites, such as the frontal cortices, the mesial temporal lobe, or the posterior cingulum. Regional glucose uptake in these sites was investigated for underlying subdimensions using factor analysis. Subsequently, the factors were examined with respect to AM performance in a subgroup of patients. Methods: Data from 109 memory clinic referrals, who presented with MCI (n = 60), mild AD (n = 49), or were cognitively intact, were analyzed. The glucose metabolic rates determined by positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) in 34 cerebral sites important for AM were investigated for underlying subdimensions by calculating factor analysis with varimax rotation. Subsequently, the respective factor scores were correlated with the episodic and semantic AM performance of 22 patients, which was measured with a semi-structured interview assessing episodic memories (characterized by event-related emotional, sensory, contextual, and spatial–temporal details) and personal semantic knowledge from three periods of life (primary school, early adulthood, and recent years). Results: Factor analysis identified seven factors explaining 69% of the variance. While patients with MCI and AD showed lower values than controls on the factors frontal cortex, mesial temporal substructures, and occipital cortex, patients with MCI presented with increased values on the factors posterior cingulum and left temporo-prefrontal areas. The factors anterior cingulum and right temporal cortex showed only minor, non-significant group differences. Solely, the factor mesial temporal substructures was significantly correlated with both episodic memories (r = 0.424, p < 0.05) and personal semantic knowledge (r = 0.547, p < 0.01) in patients with MCI/AD. Conclusions: The factor structure identified corresponds by large to the morphological and functional interrelations of the respective sites. While reduced glucose uptake on the factors frontal cortex, mesial temporal substructures, and occipital cortex in the patient group may correspond to neurodegenerative changes, increased values on the factors posterior cingulum and left temporo-prefrontal areas in MCI may result from compensatory efforts. Interestingly, changes of the mesial temporal substructures were correlated with both semantic and episodic AM. Our findings suggest that AM deficits do not only reflect neurodegenerative changes but also refer to compensatory mechanisms as they involve both quantitative losses of specific memories and qualitative changes with a semantization of memories.
V2G Multi-Objective Dispatching Optimization Strategy Based on User Behavior Model

V2G (Vehicle to Grid) technology can adjust the grid load through the unified control of the charging and discharging of electric vehicles (EVs), and achieve peak shaving and valley filling to smooth load fluctuations. Aiming at the random and uncertain problem of EV users travel and behavior decision-making, this paper proposes a V2G multi-objective dispatching strategy based on user behavior. First, a V2G behavior model was established based on user behavior questionnaire surveys, and the effective effect of EV load was simulated through Monte Carlo simulation. Then, combined with the regional daily load curve and peak-valley time-of-use electricity prices, with the goal of stabilizing grid load fluctuations and increasing the benefits of EV users, a multi-objective optimal dispatching model for EV clusters charging and discharging is established. Finally, Considering the needs of EV users and the operation constraints of the microgrid, the genetic algorithm is used to obtain the Pareto optimal solution. The results show that when dispatching with the maximum benefit of users, the peak-to-valley ratio of the grid side can be reduced by 2.99%, and the variance can be reduced by 9.52%. The optimization strategy can use peak and valley time-of-use electricity prices to guide the intelligent charging and discharging of EVs while meeting user needs, so as to achieve the optimal multi-objective benefit of V2G participation in power response.
An Individual Patient's “Body” on Chips—How Organismoid Theory Can Translate Into Your Personal Precision Therapy Approach

The first concepts for reproducing human systemic organismal biology in vitro were developed over 12 years ago. Such concepts, then called human- or body-on-a-chip, claimed that microphysiological systems would become the relevant technology platform emulating the physiology and morphology of human organisms at the smallest biologically acceptable scale in vitro and, therefore, would enable the selection of personalized therapies for any patient at unprecedented precision. Meanwhile, the first human organoids—stem cell-derived complex three-dimensional organ models that expand and self-organize in vitro—have proven that in vitro self-assembly of minute premature human organ-like structures is feasible, once the respective stimuli of ontogenesis are provided to human stem cells. Such premature organoids can precisely reflect a number of distinct physiological and pathophysiological features of their respective counterparts in the human body. We now develop the human-on-a-chip concepts of the past into an organismoid theory. We describe the current concept and principles to create a series of organismoids—minute, mindless and emotion-free physiological in vitro equivalents of an individual's mature human body—by an artificially short process of morphogenetic self-assembly mimicking an individual's ontogenesis from egg cell to sexually mature organism. Subsequently, we provide the concept and principles to maintain such an individual's set of organismoids at a self-sustained functional healthy homeostasis over very long time frames in vitro. Principles how to perturb a subset of healthy organismoids by means of the natural or artificial induction of diseases are enrolled to emulate an individual's disease process. Finally, we discuss using such series of healthy and perturbed organismoids in predictively selecting, scheduling and dosing an individual patient's personalized therapy or medicine precisely. The potential impact of the organismoid theory on our healthcare system generally and the rapid adoption of disruptive personalized T-cell therapies particularly is highlighted.
Development of a Home-Based Light Therapy for Fatigue Following Traumatic Brain Injury: Two Case Studies

Background and Objectives: Fatigue and sleep disturbance negatively impact quality of life following brain injury and there are no established treatments. Building on research showing efficacy of blue light therapy delivered via a lightbox in reducing fatigue and daytime sleepiness after traumatic brain injury (TBI), this paper describes the development and implementation of a novel in-home light therapy to alleviate fatigue and sleep disturbance in two case studies. Methods: During the 8-week lighting intervention, participants' home lighting was adjusted to provide high intensity, blue-enriched (high melanopic) light all day as a stimulant and dimmer, blue-depleted (low melanopic) light for 3 h before sleep as a soporific. The sham 8-week control condition resembled participants' usual (baseline) lighting conditions (3,000–4,000 K all day). Lighting conditions were crossed-over. Outcomes were measures of fatigue, subjective daytime sleepiness, sleep quality, insomnia symptoms, psychomotor vigilance and mood. Case study participants were a 35-year old male (5 years post-TBI), and a 46-year-old female (22 years post-TBI). Results: The relative proportion of melanopic lux was greater in Treatment lighting than Control during daytime, and lower during evenings. Participants found treatment to be feasible to implement, and was well-tolerated with no serious side effects noted. Self-reported compliance was >70%. Both cases demonstrated reduced fatigue, sleep disturbance and insomnia symptoms during the treatment lighting intervention. Case 2 additionally showed reductions in daytime sleepiness and depressive symptoms. As expected, symptoms trended toward baseline levels during the control condition. Discussion: Treatment was positively received and compliance rates were high, with no problematic side-effects. Participants expressed interest in continuing the ambient light therapy in their daily lives. Conclusions: These cases studies demonstrate the acceptability and feasibility of implementing a personalized in-home dynamic light treatment for TBI patients, with evidence for efficacy in reducing fatigue and sleep disturbance. Clinical Trial Registration: www.anzctr. org.au, identifier: ACTRN12617000866303.
Low Level of Perfectionism as a Possible Risk Factor for Suicide in Adolescents With Attention-Deficit/Hyperactivity Disorder

Introduction: Suicide is one of the leading causes of death among adolescents. Although it is known that both perfectionism and attention-deficit/hyperactivity disorder (‘ADHD’) are important risk factors for suicide, there are no studies that have investigated the relationship between suicidal behavior and perfectionism among people with ADHD. Aim: The current study investigates the association between perfectionism and suicide in adolescents with ADHD. Method: Subjects included 88 adolescents with ADHD and 96 non-clinical control adolescents. We used the Multidimensional Perfectionism Scale to evaluate perfectionism as well as its separate traits, and the Mini International Neuropsychologic Interview Kid to evaluate psychiatric disorders and suicidal behavior. Differences between the groups were statistically evaluated using t-tests, a Poisson regression analysis with suicide as a discrete variable, and a logistic regression analysis with suicide as a binary variable. Results: Compared to the control group, the ADHD group showed a significantly lower level on the adaptive ‘Organization’ trait of perfectionism, but not on any other trait, and a significantly higher level of suicidal behavior. Logistic regression results indicated a significant association for perfectionism in general (OR = 0.93, p = 0.003), and for the ‘Personal Standards’ trait (OR: 0.82, p = 0.039). Poisson regression analysis also showed a significant association with perfectionism in general (IRR = 0.90; p < 0.001) and with the ‘Personal standards’ trait model (IRR = 0.81, p = 0.019). Discussion: Our results indicate that a low level of perfectionism, in particular ‘Personal standards’, may be a risk factor for suicidal behavior in adolescents with ADHD. We recommend that psychoeducation and therapy of adolescents with ADHD should consider focusing on adaptive perfection as a possible risk factor for suicide as well.
Ginsenoside Rg3 Promotes Cell Growth Through Activation of mTORC1

Ginsenoside Rg3 is a steroidal saponin isolated from Panax ginseng. Previous studies have shown that Rg3 treatment downregulates the activity of rapamycin complex 1 (mTORC1) activity and inhibits the growth of cancer cells. However, the inhibitory effect of Rg3 on cancer cells is associated with high concentrations of Rg3 that are difficult to achieve in vivo. The human cervix adenocarcinoma HeLa cells were treated with Rg3. The protein levels of AMP-activated protein kinase alpha (AMPKα), protein kinase B(Akt), ribosomal S6 protein(S6), and Erk were determined by immunoblotting analyses. We used a fluorescent probe to detect reactive oxygen species (ROS) production in living cells. The oxygen consumption rate (OCR) was examined by the Seahorse Extracellular Flux Analyzer. The content of adenosine triphosphate (ATP) was measured by ATPlite kit and Mitotracker was applied to detect the mitochondria. We showed that at lower concentrations, Rg3 activates mTORC1 independent of AKT and AMP-activated protein kinase (AMPK). Rg3 promotes mitochondrial biogenesis and function, increases the oxygen consumption of mitochondria and the content of ATP. This effect is in contrast to that of high concentrations of Rg3, which inhibits cell growth. These findings demonstrate a pro-growth activity of Rg3 that acts through mTORC1 and mitochondrial biogenesis and suggest a dose-dependent effect of Rg3 on tumor cell growth. Graphical Abstract Ginsenoside Rg3 promotes cell growth through activation of mTORC1 and increasing mitochondrial biogenesis.
Solar light driven photocatalytic degradation of levofloxacin using TiO2/carbon-dot nanocomposites

This paper reports the synthesis of TiO2 quantum dots, carbon dots (C-dots), and TiO2/C-dots using facile sol–gel and hydrothermal methods. The synthesized quantum dots were further characterized in detail to understand their crystalline, structural, morphological, thermal and optical properties using various spectroscopic and analytical techniques. The characterization results confirmed that the prepared photocatalysts exhibited high crystallinity, purity and excellent optical properties. The morphological results indicated that the C-dots were uniformly distributed over the TiO2 quantum dots and nanocomposites have an average size of 12 nm. Furthermore, the prepared sample, i.e. TiO2/C-dots, was efficiently employed as a potential heterogeneous photocatalyst for solar light driven photocatalytic degradation of a fluoroquinolone antibiotic drug levofloxacin. To optimize the photocatalytic degradation experiments, various catalyst dose-dependent, pH-dependent, and initial drug-concentration dependent experiments were carried out. The photocatalytic experiments revealed almost complete photocatalytic degradation of levofloxacin (10 mg L−1) within 90 minutes of solar light illumination using the TiO2/C-dots under optimum conditions, whereas bare TiO2 showed only 66.5% degradation of the drug. Different commercial photocatalysts such as TiO2 PC-50 and TiO2 PC-500 were also used for comparing the photocatalytic efficiency of the synthesized photocatalyst. Furthermore, the stability of the photocatalyst was studied by performing recyclability experiments up to 5 cycles using the TiO2/C-dots, indicating that the nanocomposites could be reused without any significant loss. The TOC results indicated the simultaneous 53.4% mineralization and photocatalytic degradation of levofloxacin under optimized conditions. The enhanced photocatalytic activity of the nanocomposites was attributed to the presence of the C-dots in the system, which provided more active sites for the drug molecules and also restricted the recombination of charge carriers. The role of active radical species in the photocatalytic degradation of levofloxacin was also investigated. A photocatalytic degradation mechanism and pathway were also proposed.
Understanding a molecular motor walking along a microtubule: an asymmetric Brownian motor driven by bubble formation with a focus on binding affinity

Abstract In recent years, many studies on a molecular motor have been conducted in the fields of biorheology and nanoengineering. The molecular motor is a molecule that converts the chemical energy obtained by ATP hydrolysis into mechanical energy. Explaining this mechanism is important for nanoengineering. A kinesin, which is a type of molecular motor, has the characteristics to move on a microtubule with hand-over-hand steps. The kinesin walking behaviour is explained by the ‘asymmetric Brownian ratchet model’. Previously, we had suggested that the walking mechanism was achieved by the bubble formation in a nanosized channel surrounded by hydrophobic atoms with the transition between the two states – bubble state and liquid state. However, the walking behaviour of the model motor was different from that of a single molecule measurement of a kinesin. In this study, we constructed a new motor system focused on the asymmetric binding affinity of a motor protein and performed a model simulation using the dissipative particle dynamics method. As a result, it was observed that hand-over-hand walking depends on the transition position ratio and the transition frequency coefficient. Moreover, the efficiency of the new motor system is higher than that of the previous motor systems. The new motor model can provide a simulation guide for the design of biomimetic nanomachines.
One-step esterification of nanocellulose in a Brønsted acid ionic liquid for delivery to glioblastoma cancer cells

The Fisher esterification reaction has been exploited for linking a peptide (chlorotoxin) onto the surface of nanocellulose using a Bronsted acid ionic liquid both as a solvent and a catalyst. Indeed, cellulose nanocrystals were functionalized with the peptide thanks to a mild, one-step and organic solvent-free reaction. The obtained nanocellulose showed excellent properties in terms of biocompatibility and internalization in the U87MG glioblastoma cell line, thus demonstrating the possible use of this material as a novel drug delivery carrier.
Genetic, Protein and FTIR Spectroscopic Comparison of Anterior and Posterior Deciduous Dental Pulp for Subsequent Obtention of SHED

1 Escuela Militar de Medicina, Centro Militar de Ciencias de la Salud, Secretaria de la Defensa Nacional, Ciudad de Mexico, C.P. 11200, Mexico. CIBA-Tlaxcala, Instituto Politecnico Nacional, Tepetitla, Tlaxcala, 90700, Mexico. 3 Unidad de Especialidades Odontologicas, Secretaria de la Defensa Nacional, Ciudad de Mexico, C.P. 11200, Mexico. Escuela Nacional de Medicina y Homeopatia, Instituto Politecnico Nacional, Ciudad de Mexico, C.P. 07320, Mexico.
Review of conceptual design and fundamental research of molten salt reactors in China

Molten salt reactor (MSR) as 1 candidate of the generation IV advanced nuclear power systems attracted more attention in China due to its top ranked in fuel cycle and thorium utilization. Two types of MSR concepts were studied and developed in parallel, namely the MSR with liquid fuel and that with solid fuel. Abundant fundamental research including the neutronics modeling, thermal‐hydraulics modeling, safety analysis, material investigation, molten salts technologies etc. were carried out. Some analysis software such as COUPLE and FANCY were developed. Several experimental facilities like high‐temperature fluoride salt experiment loop have been constructed. Some passive residual heat removal systems were designed, and 1 test facility is under construction. The key MSR techniques including the extraction and separation of molten salt and construction of N‐base alloy have been mastered. Based on these fundamental research, Chinese Academy of Sciences has completed the design of thorium‐based MSRs with solid fuel and liquid fuel and is promoting their construction in the near future. In China, future efforts should be paid to the material, online fuel processing, Th‐U fuel cycle, component design, and construction and thermal‐hydraulic experiments for MSR, which are rather challenging nowadays.
Technological Innovations Utilization Framework: The Complementary Powers of UTAUT, HOT–Fit Framework and; DeLone and McLean IS Model

: Theories and models have been developed to explore the diffusion, adoption or acceptance and utilization of Technological Innovations. The literature traversed fortifies the successful utilization of technological innovations on a number of contexts which are identified in three broad zones as; technological, organizational and human context. It’s however disquieting that none of the theories and models traversed in the literature distinctively underpins these contexts conclusively. To appreciate the above contexts, this study settles on the underneath twin models and solitary framework as the combination is believed to exhaustively wrestle the phenomena. Disregarding the concept of parsimony and embracing a post-positivist approach to theory development affixing the foundation on an exploratory sequential method design utilizing existing literature especially on adoption, usage, acceptance, implementation and utilization of technology, the study thus develops a multi-dimensional theoretical framework, derived from DeLone and McLean model, UTAUT and HOT-fit Framework.
Detection of dentinal cracks after use of piezoelectric device and surgical bur during root-end resection: An ex vivo comparative study

Introduction: The piezoelectric device was implemented successfully in many oral and maxillofacial surgeries. However, in endodontic surgery, it is not widely used due to lack of scientific support. Thus, the aim of the conducted study was to compare the formation of the cracks of roots resected with piezoelectric surgery versus high-speed surgical bur using scanning electron microscopy. Materials and Methods: Sixty single-rooted human teeth were accessed followed by canal preparation with rotary files and filled with gutta-percha. The teeth were mounted on plastic cylindrical test tubes and emerged within the impression material to simulate periodontal ligament. Consequently, the teeth were divided into three groups: the control group (n = 10), piezoelectric group (n = 25), and the surgical bur group (n = 25). The surface of the resected root was examined under scanning electron microscopy for cracks detection. The one-way analysis of variance test was used to investigate the number and types of cracks at a significance level of 95%. Results: Dentinal cracks were detected in all groups. However, there was no statistically significant difference in the number of cracks between the three groups, but they differed in terms of crack type. Conclusions: All tested groups produce cracks on resected root surface, whereas the piezoelectric presented with satisfactory result.
The effect of body mass index on high versus low administered activity protocol myocardial perfusion imaging scan time and effective dose using a cadmium zinc telluride camera in clinical practice

Cadmium Zinc Telluride (CZT) crystal-based myocardial perfusion imaging (MPI) cameras have increased count sensitivity compared to Anger cameras and can be used to lower either the injected activity or the image acquisition time. Institutions adopting CZT cameras need to decide whether to lower the injected activity or imaging time or attempt to lower both with a compromise. The aim of our study was to compare the scan time required to obtain similar count images using high activity protocol (HAP) versus low activity protocol (LAP) stratified by body mass index (BMI) and assess the impact on effective dose and our clinic workflow. Using a CZT camera, a cohort of 100 consecutive clinical patients imaged with LAP rest-stress MPI with approximately 185 MBq and 555 MBq activity was retrospectively compared to a similar cohort of 100 consecutive clinical patients imaged with HAP rest-stress MPI using approximately 370 MBq and 1110 MBq. Administered activity and BMI both had a statistically significant effect on scan time and radiation effective dose. LAP scans took an average of 9 min longer than HAP scans overall, P < 0.0001 and larger BMIs took longer than smaller BMIs, P < 0.0001. In addition, scan times were longer in men than women, P = 0.007. Effective dose was inversely proportional to BMI with an overall decrease of approximately 50% comparing LAP to HAP. For the same CZT camera, the LAP increased scan time while lowering the radiation effective dose when compared to HAP. The increase in scan time increased proportionally to BMI. The effective dose was inversely proportional to BMI. This increase in time did not have a significant impact on our local workflow, but its implications should be considered in the setting of LAP implementation, especially in obese or high patient volume practices.