Miracle-dz/UniFAR-FTUs huggingface dataset:
Microarchitectural Minefields: 4K-Aliasing Covert Channel and Multi-Tenant Detection in Iaas Clouds

We introduce a new microarchitectural timing covert channel using the processor memory order buffer (MOB). Specifically, we show how an adversary can infer the state of a spy process on the Intel 64 and IA-32 architectures when predicting dependent loads through the store buffer, called 4K-aliasing. The 4K-aliasing event is a side-effect of memory disambiguation misprediction while handling write-after-read data hazards wherein the lower 12-bits of a load address will falsely match with store addresses resident in the MOB. In this work, we extensively analyze 4K-aliasing and demonstrate a new timing channel measureable across processes when executed as hyperthreads. We then use 4K-aliasing to build a robust covert communication channel on both the Amazon EC2 and Google Compute Engine capable of communicating at speeds of 1.28 Mbps and 1.49 Mbps, respectively. In addition, we show that 4K-aliasing can also be used to reliably detect multi-tenancy.
New GABA modulators protect photoreceptor cells from light‐induced degeneration in mouse models

No clinically approved therapies are currently available that prevent the onset of photoreceptor death in retinal degeneration. Signaling between retinal neurons is regulatedby the release and uptake of neurotransmitters, wherein GABA is the main inhibitory neurotransmitter. In this work, novel 3‐chloropropiophenone derivatives and the clinical anticonvulsants tiagabine and vigabatrin were tested to modulate GABA signaling and protect against light‐induced retinal degeneration. Abca4−/− Rdh8−/− mice, an accelerated model of retinal degeneration, were exposed to intense light after prophylactic injections of one of these compounds. Imaging and functional assessments of the retina indicated that these compounds successfully protected photoreceptor cells from degeneration to maintain a full‐visual‐field response. Furthermore, these compounds demonstrated a strong safety profile in wild‐type mice and did not compromise visual function or damage the retina, despite repeated administration. These results indicate that modulating inhibitory GABA signaling can offer prophylactic protection against light‐induced retinal degeneration. —Schur, R. M. , Gao, S. , Yu, G. , Chen, Y. , Maeda, A. , Palczewski, K. , Lu, Z. ‐R. New GABA modulators protect photoreceptor cells from light‐induced degeneration in mouse models. FASEB J. 32, 3289–3300 (2018). www.fasebj. org
Aero-Engine Lubricating Oil Metal Content Prediction Using Non-stationary Time Series ARIMA Model

Aero-engine lubricating oil metal content is a reflection of abrasion and fracture of aero-engine key components. By predicting the metal elements concentration, it is possible to detect the mechanical faults of the corresponding parts in advance, to guarantee flight safety and to reduce the maintenance cost of the aero-engine. The metal element concentration of the aero-engine lubricating oil is influenced by many complicated factors and its change tendency is difficult to be predicted. To solve this problem, an aero-engine lubricating oil metal element concentration prediction method based on the non-stationary time series ARIMA (Autoregressive Integrated Moving Average) model was proposed, the corresponding algorithm model and modeling process of the ARIMA were introduced in detail, and the prediction results are satisfying. The application of ARIMA model in forecasting the aero-engine lubricating oil metal elements concentration was analyzed by examples. To compare with the result of moving average and exponential smoothing method, the proposed method has better fitting and forecasting precision, the research result shows the accuracy and feasibility of aero-engine lubricating oil metal elements concentration forecasting using ARIMA model.
A genetic analysis of meat compositions in Japanese Black cattle: Genetic parameters and sex influence

Meat composition in beef is related to eating quality and food functionality. Genetic parameters for several meat compositions including free amino acid, peptide and sugar, however, remain poorly described. In this study, we estimated genetic parameters for 51 meat components, including free amino acids, peptides, sugars and fatty acid compositions, and two carcase traits in 1,354 heifers and 1,797 steers of Japanese Black cattle. Heritability estimates were generally equivalent to or moderately greater than those in previous studies of this breed. Genetic correlations between free amino acids, peptides and sugars and carcase traits were often negative, suggesting a trade-off between traits. Using two-trait animal models that treat records from the two sexes as different traits, we estimated sex-specific heritabilities and cross-sex genetic correlations which indicate the sex differences in genetic architecture. In these analyses, 12 traits showed significant heritability differences between sexes and cross-sex genetic correlations occasionally deviated from unity. These results could be used to inform future breeding schemes and investigations of the genetic architecture of meat compositions in beef.
Promoting Interprofessional Collaborative Practice Through Simulation

Abstract A 12-week program was developed to educate nursing, medicine, and physician assistant faculty on the principles and best practices of simulation. The goal was to facilitate team building and collaborative practice through the implementation of an interprofessional (IP) simulation experience for students. Workshops focused on IP communication involving seminar-based instruction, discussion, and the progressive development of an IP simulation based on a National League for Nursing Advancing Care Excellence for Seniors scenario. During the final session, students participated in the simulation while faculty evaluated and revised the scenario to best meet the needs of students from the three disciplines.
Wideband Gain Enhancement and RCS Reduction of Fabry–Perot Resonator Antenna With Chessboard Arranged Metamaterial Superstrate

The simultaneous improvement in radiation and scattering performance of an antenna is normally considered as contradictory. In this paper, wideband gain enhancement and radar cross section (RCS) reduction of Fabry–Perot (FP) resonator antenna are both achieved by using chessboard arranged metamaterial superstrate (CAMS). The CAMS is formed by two kinds of frequency-selective surfaces. The upper surface of CAMS is designed to reduce RCS based on the phase cancellation principle, and the bottom surface is used to enhance antenna gain on the basis of FP resonator cavity theory. Both simulation and measured results indicate that compared with primary antenna, the gain of the proposed FP resonator antenna is enhanced by 4.9 dB at 10.8 GHz and the 3 dB gain bandwidth is from 9.4 to 11.1 GHz (16.58%). Meanwhile, the RCS of the proposed FP resonator antenna is reduced from 8 to 18 GHz, with peak reduction of 39.4 dB. The 10 dB RCS reduction is obtained almost from 9.6 to 16.9 GHz (55.09%) for arbitrary polarizations. Moreover, the in-band RCS is greatly reduced, owing to the combined effect of CAMS and FP resonator cavity.
Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons

Parkinson’s disease is characterized by the loss of dopamine (DA) neurons in the substantia nigra pars compacta (SNc). DA neurons in the ventral tegmental area are more resistant to this degeneration than those in the SNc, though the mechanisms for selective resistance or vulnerability remain poorly understood. A key to elucidating these processes may lie within the subset of DA neurons that corelease glutamate and express the vesicular glutamate transporter VGLUT2. Here, we addressed the potential relationship between VGLUT expression and DA neuronal vulnerability by overexpressing VGLUT in DA neurons of flies and mice. In Drosophila, VGLUT overexpression led to loss of select DA neuron populations. Similarly, expression of VGLUT2 specifically in murine SNc DA neurons led to neuronal loss and Parkinsonian behaviors. Other neuronal cell types showed no such sensitivity, suggesting that DA neurons are distinctively vulnerable to VGLUT2 expression. Additionally, most DA neurons expressed VGLUT2 during development, and coexpression of VGLUT2 with DA markers increased following injury in the adult. Finally, conditional deletion of VGLUT2 made DA neurons more susceptible to Parkinsonian neurotoxins. These data suggest that the balance of VGLUT2 expression is a crucial determinant of DA neuron survival. Ultimately, manipulation of this VGLUT2-dependent process may represent an avenue for therapeutic development.
Echinococcus multilocularis in a Eurasian lynx (Lynx lynx) in Turkey

Abstract Echinococcus multilocularis is the causative agent of alveolar echinococcosis (AE), one of the most threatening zoonoses in Eurasia. Human AE is widespread in the Erzurum region of Turkey, but the situation of the disease in intermediate and definitive hosts is unknown. A Eurasian lynx (Lynx lynx) was killed in a traffic accident in the north of Erzurum, and was taken to our laboratory. Sedimentation and counting technique (SCT), DNA isolation and polymerase chain reaction (PCR) analysis were performed. The SCT results showed that the lynx was infected with E. multilocularis with a medium (745 worms) worm burden. The DNA of adult worms obtained from the lynx was analyzed with a species-specific PCR, and the worms were confirmed to be E. multilocularis by 12S rRNA gene sequence analysis. This is the first report of E. multilocularis from Eurasian lynx in Turkey.
Health Literacy Among Insulin-Taking African Americans

Aims To determine the levels of functional health literacy (FHL) among insulin-taking African Americans with diabetes from an urban medical practice and to determine if associations exist between FHL levels and glycemic control. Methods Seventy insulin-taking African Americans seen for diabetes management comprised the analysis cohort. Patients were 18 years or older, African American, had diabetes, and currently using insulin via syringe, pen, or insulin pump. All participants completed a one-time assessment of FHL levels, using the Newest Vital Sign (NVS). Scores ranged from 0 to 6 (0-1 = high likelihood of limited FHL; 2-3 = possibility of limited FHL; 4-6 = adequate FHL). A combination of t tests, Pearson’s chi-square tests, and multivariate logistic regression models were used to determine associations between glycemic control and FHL. Results Average age was 58.7, 59.1% were female, 90.8% with type 2 diabetes, and 15.1% using an insulin pump. Glycemic control was: A1C < 7%: 22.9%, A1C < 8%: 47.1%. Of participants, 47.1% had adequate FHL, 31.4% had possible limited FHL, and 21.4% had a high likelihood of limited FHL. Also, 67.7% of participants with A1C ≥ 8% had a high likelihood of limited FHL. After adjusting for age and gender, participants with a high likelihood of limited FHL were 6.2 times (95% confidence interval [CI], 1.4-28.3) more likely to have A1C ≥ 8%. Conclusions Insulin-taking African Americans with a high likelihood of limited FHL are approximately 6 times more likely to have an A1C ≥ 8% compared to patients with a possibility of limited FHL, or adequate FHL, demonstrating the need for focused interventions tailored to FHL needs.
Qualitative analysis and conceptual mapping of patient experiences in home health care

ABSTRACT This study explored patient experiences in home health care through a literature review, focus groups, and interviews. Our goal was to develop a conceptual map of home health care patient experience domains. The conceptual map identifies technical and personal spheres of care, relating prior studies to new focus group and interview findings and identifying the most important domains of care. Study participants (n = 35) most frequently reported the most important domain as staff who are caring, supportive, patient, empathetic, respectful, and considerate (endorsed by 29% of participants). The conceptual map includes 114 discrete domains.
Maraviroc Is Associated with Latent HIV-1 Reactivation through NF-κB Activation in Resting CD4+ T Cells from HIV-Infected Individuals on Suppressive Antiretroviral Therapy

ABSTRACT Maraviroc is a CCR5 antagonist used in the treatment of HIV-1 infection. We and others have suggested that maraviroc could reactivate latent HIV-1. To test the latency-reversing potential of maraviroc and the mechanisms involved, we performed a phase II, single-center, open-label study in which maraviroc was administered for 10 days to 20 HIV-1-infected individuals on suppressive antiretroviral therapy (EudraCT registration no. 2012-003215-66). All patients completed full maraviroc dosing and follow-up. The primary endpoint was to study whether maraviroc may reactivate HIV-1 latency, eliciting signaling pathways involved in the viral reactivation. An increase in HIV-1 transcription in resting CD4+ T cells, estimated by levels of HIV-1 unspliced RNA, was observed. Moreover, activation of the NF-κB transcription factor was observed in these cells. To elucidate the mechanism of NF-κB activation by maraviroc, we have evaluated in HeLa P4 C5 cells, which stably express CCR5, whether maraviroc could be acting as a partial CCR5 agonist, with no other mechanisms or pathways involved. Our results show that maraviroc can induce NF-κB activity and that NF-κB targets gene expression by CCR5 binding, since the use of TAK779, a CCR5 inhibitor, blocked NF-κB activation and functionality. Taking the results together, we show that maraviroc may have a role in the activation of latent virus transcription through the activation of NF-κB as a result of binding CCR5. Our results strongly support a novel use of maraviroc as a potential latency reversal agent in HIV-1-infected patients. IMPORTANCE HIV-1 persistence in a small pool of long-lived latently infected resting CD4+ T cells is a major barrier to viral eradication in HIV-1-infected patients on antiretroviral therapy. A potential strategy to cure HIV-1-infection is the use of latency-reversing agents to eliminate the reservoirs established in resting CD4+ T cells. As no drug has been shown to be completely effective so far, the search for new drugs and combinations remains a priority for HIV cure. We examined the ability of maraviroc, a CCR5 antagonist used as an antiretroviral drug, to activate latent HIV-1 in infected individuals on antiretroviral therapy. The study showed that maraviroc can activate NF-κB and, subsequently, induce latent HIV-1-transcription in resting CD4+ T cells from HIV-1-infected individuals on suppressive antiretroviral therapy. Additional interventions will be needed to eliminate latent HIV-1 infection. Our results suggest that maraviroc may be a new latency-reversing agent to interfere with HIV-1 persistence during antiretroviral therapy.
Integration of Oncogenes via Sleeping Beauty as a Mouse Model of HPV16+ Oral Tumors and Immunologic Control

A preclinical mouse model of spontaneous, HPV+ oral tumors was generated. Sleeping beauty transposase system-mediated oncogene transfection was assisted by electroporation. This model allowed for the evaluation of disease intervention efficacy and analysis of tumor cell migration. Human papillomavirus type 16 (HPV16) is the etiologic factor for cervical cancer and a subset of oropharyngeal cancers. Although several prophylactic HPV vaccines are available, no effective therapeutic strategies to control active HPV diseases exist. Tumor implantation models are traditionally used to study HPV-associated buccal tumors. However, they fail to address precancerous phases of disease progression and display tumor microenvironments distinct from those observed in patients. Previously, K14-E6/E7 transgenic mouse models have been used to generate spontaneous tumors. However, the rate of tumor formation is inconsistent, and the host often develops immune tolerance to the viral oncoproteins. We developed a preclinical, spontaneous, HPV16+ buccal tumor model using submucosal injection of oncogenic plasmids expressing HPV16-E6/E7, NRasG12V, luciferase, and sleeping beauty (SB) transposase, followed by electroporation in the buccal mucosa. We evaluated responses to immunization with a pNGVL4a-CRT/E7(detox) therapeutic HPV DNA vaccine and tumor cell migration to distant locations. Mice transfected with plasmids encoding HPV16-E6/E7, NRasG12V, luciferase, and SB transposase developed tumors within 3 weeks. We also found transient anti-CD3 administration is required to generate tumors in immunocompetent mice. Bioluminescence signals from luciferase correlated strongly with tumor growth, and tumors expressed HPV16-associated markers. We showed that pNGVL4a-CRT/E7(detox) administration resulted in antitumor immunity in tumor-bearing mice. Lastly, we demonstrated that the generated tumor could migrate to tumor-draining lymph nodes. Our model provides an efficient method to induce spontaneous HPV+ tumor formation, which can be used to identify effective therapeutic interventions, analyze tumor migration, and conduct tumor biology research. Cancer Immunol Res; 6(3); 305–19. ©2018 AACR.
Analysis and design of tourism information system: A study of rote ndao Indonesia

The paper will present to analyze and design a tourism information system, which is based website that functions as a means of tourism information services and for promoting tourism in Indonesia specially Rote Ndao District. This information system has comprehensive information on the public and tourists. Methods of data collection on this study are collecting data through literature studies, interviews, and observations and analyze software requirements set out. There are two types of data, First Data, and secondary data. The collection of primary data used freely conducts interviews or does not use the guideline systematically with relevant parties and makes observations attractions in Rote Ndao District and the Department of Tourism and Culture Rote Ndao District. As for the secondary data for the analysis and design of this is data on tourism from books, journals, results of previous studies, brochures, and browsing the Internet. The result from the design of information systems in the form of web-based tourism is expected to become a medium of information and can promote tourism Rote Ndao.
Interlinked hybrid microgrids with fault confining capability using a novel MMC topology

This paper presents a solution for the fault current elevation in interlinked hybrid microgrids. In hybrid ac-dc microgrids, the control strategy of the interlinking converter allows the distributed generators (DGs) in either microgrid to respond to any load changes in the other microgrid. This load sharing strategy result in a contribution from all DGs to the fault current in either microgrid. Therefore, a new methodology to eliminate the fault current contribution between interlinked hybrid microgrids is proposed in this work. This methodology quarantines the fault inside each microgrid and thus prevents the other microgrid from contributing to the fault current through blocking any continuous current paths. A novel Modular Multilevel Converter (MMC) topology called Modified Switched Capacitor Submodule (MSCSM) has been used to realize the fault confining strategy. A case study has been implemented to prove the effectiveness of the proposed methodology in confining the fault within its zone and preventing any inter-microgrids contribution. The results show the successful converter operation regards blocking any current contribution from the ac-microgrid when a fault occurs in the dc-microgrid thus the fault was effectively quarantined in the dc-microgrid.
Nematicity, magnetism and superconductivity in FeSe

Iron-based superconductors are well known for their complex interplay between structure, magnetism and superconductivity. FeSe offers a particularly fascinating example. This material has been intensely discussed because of its extended nematic phase, whose relationship with magnetism is not obvious. Superconductivity in FeSe is highly tunable, with the superconducting transition temperature, Tc, ranging from 8 K in bulk single crystals at ambient pressure to almost 40 K under pressure or in intercalated systems, and to even higher temperatures in thin films. In this topical review, we present an overview of nematicity, magnetism and superconductivity, and discuss the interplay of these phases in FeSe. We focus on bulk FeSe and the effects of physical pressure and chemical substitutions as tuning parameters. The experimental results are discussed in the context of the well-studied iron-pnictide superconductors and interpretations from theoretical approaches are presented.
Extreme learning machine autoencoder for data augmentation

Some databases used in computer vision problems have a few number of data points. It makes harder to the classifier to increase its generalization capability. One strategy applied to solve this issue is data augmentation. This solution aims to generate more data to improve the performance of the classifier. In this paper, we propose a model that uses images produced by an Extreme Learning Machine Autoencoder (ELM- AE) to make data augmentation. We selected the autoencoder approach since it is more straightforward and efficient than other data augmentation strategies. We evaluate our proposal in a facial expression recognition problem using the Japanese Female Facial Expression (JAFFE) database, and we assess the impact of the data augmentation in the performance considering K-Nearest Neighbors (KNN), Support Vector Machines (SVM) and Convolutional Neural Network (CNN). The obtained results show that our approach is an appropriate alternative for data augmentation tasks, also reaching better results when compared to other common strategies in most of the cases.
SFN-SIQ, SFNSL and skin biopsy of 55 cases with small fibre involvement

ABSTRACT Purpose/aim of the study: To date, there are no validated screening scales for small fibre neuropathy. This study investigated the small-fibre neuropathy and the symptom inventory questionnaire as well as the small fibre neuropathy screening list for small fibre neuropathy diagnosis. Methods: Fifty-five patients were divided into small fibre neuropathy and mixed fibre damage groups. Relevant scales, nerve conduction studies and skin biopsies were performed. Relationships between the intraepidermal nerve fibre density and different scales as well as the diagnostic and cut-off values (score at which Youden's index is largest) were determined. Results: Compared with healthy Chinese participants, 20 patients were diagnosed with small fibre neuropathy. Intraepidermal nerve fibre density was moderately and highly correlated with the small fibre neuropathy–symptom inventory questionnaire and small fibre neuropathy screening list, respectively. The diagnostic values were moderate and high for the small fibre neuropathy–symptom inventory questionnaire (cut-off value = 5, sensitivity = 80%, specificity = 81.8%) and small fibre neuropathy screening list (cut-off value = 8, sensitivity = 94.1%, specificity = 90.9%), respectively. There were no significant differences in the visual analogue scale between the small fibre neuropathy group, mixed small and large fibre neuropathy group, pure large fibre neuropathy group and the normal group. Conclusion: Small fibre neuropathy–symptom inventory questionnaire and small fibre neuropathy screening list represent potential small fibre neuropathy screening tools. AbbreviationsEMG electromyographyENA anti-extractable nuclear antigensESR erythrocyte sedimentation rateIENFD intraepidermal nerve fibre densityIGT impaired glucose toleranceNCS nerve conduction studiesNDS neuropathy disability scoreOGTT oral glucose tolerance testPGP protein gene productPN peripheral neuropathyROC receiver operating characteristic curveROC-AUC area under the ROC curveSFN small fibre neuropathySFN–SIQ small-fibre neuropathy and symptom inventory questionnaireSFNSL small fibre neuropathy screening listVAS visual analogue scaleWHO World Health Organization