Miracle-dz/UniFAR-FTUs huggingface dataset:
Small molecule stabilization of non-native protein-protein interactions of SARS-CoV-2 N protein as a mechanism of action against COVID-19

Abstract The outbreak of COVID-19, the disease caused by SARS-CoV-2, continues to affect millions of people around the world. The absence of a globally distributed effective treatment makes the exploration of new mechanisms of action a key step to address this situation. Stabilization of non-native Protein-Protein Interactions (PPIs) of the nucleocapsid protein of MERS-CoV has been reported as a valid strategy to inhibit viral replication. In this study, the applicability of this unexplored mechanism of action against SARS-CoV-2 is analyzed. During our research, we were able to find three inducible interfaces of SARS-CoV-2 N protein NTD, compare them to the previously reported MERS-CoV stabilized dimers, and identify those residues that are responsible for their formation. A drug discovery protocol implemented consisting of docking, molecular dynamics and MM-GBSA enabled us to find several compounds that might be able to exploit this mechanism of action. In addition, a common catechin skeleton was found among many of these molecules, which might be useful for further drug design. We consider that our findings could motivate future research in the fields of drug discovery and design towards the exploitation of this previously unexplored mechanism of action against COVID-19. Communicated by Ramaswamy H. Sarma
Notes on Hepaticology

branches, dense, short-peduncled; heads few (3 10), on short pedicels; flowers blue. South Florida. Stem 1-2 feet higlh. Leaves 1-1 in. long. Flowers smaller than those ef C. ccelestinum, bloomir. g, in cultivation, firomi May until frost. Oocliniurm rigidum, DC. Fruteseent at base, closely pubescent; stems numerous, erect, branching; leaves opposite, ovate, crenate-serrate, acute, longer tlhani tlhe petioles; pedicels single, or 2-3 together in tlle forks of the branches, unequial, longer than the cylindrical miany-flowered lheads; scales of tlle involuere smootlh, closely imbricate, striate, obtuse, deciduous; flowers (about 20) pale blue; aclhenium smootlh, 3-4-angular; receptacle globular or truneate naked. -Jew-fish Key, Soutlh Flor ida. Novenmber. Plant 2 feet hiiglh, exhaling a strong unpleasant odor. Acantho8permum xcanthloideO , DC. Stem prostrate, (liffusely branching, plubescent; leaves opposite, oval or obovate, tootlhed or entile; lhea(ds singlc, teriiiinal ancl in the forks of the branches, many-flowered; rays yellow; clhaff of tlle recel)tacle obtuse, unarmed at the tip. -Aiken, South Carolina (Ravenel), Atlanta and Savannall, Georgia, Jacksonville alnd Gainesville, Florida. Actinomeri8 heterophylla, n. sp. Stemil erect, mostly simple, sparingly hirsute, terete and nearly naked above, the lower part winged by the decurrent leaves; leaves nliuricate, the lower ones oblong, opposite, afpproximate, lhalf clasping, serrate, decurrent, tlle uip per linear, opposite or alternate, smnall (2-1 in. long), remote, entire; lhcads solitary or corymbose, on slender peduncles; scales of the involucre lanceolate, mostly slhorter than the disk, shorter than the 5-10 linear yellow rays; chlatff of the receptacle rigid, acute, longer than the obovate narrowly winged 1-2 awned achenium-. Sandy pine barrens, East Florida. Stem 2-3 feet high. Leaves 2-3 in. long.
St Lawrence Seaway: Eastern Great Lakes, the Niagara River and Welland Canal Replacement, Maintenance and Protection

The Eastern Great Lakes region covers 51,000 square km of land, and is home to 15 million people. This region is rich in natural resources, industry and agriculture, and forms the heartland of both Canada and the United States. The development of this region has a history that is closely tied to waterways, and the development of canals that promoted growth and prosperity. The St. Lawrence Seaway connects Western and Eastern Great Lakes to the St Lawrence River and the Gulf of Saint Lawrence. The New York State Canal and the St. Lawrence Seaway were linked by the Oswego canal and provided a shorter route for cargo via barges to New York City. The New York State (NYS) Barge Canal and the St. Lawrence Seaway provided pathways for the settlement of the Eastern Great Lakes. Lake Erie drains into Lake Ontario via the Niagara River but the river was not navigable due to the obstacles of Niagara Falls and the Niagara Escarpment. Until the 1820s ships could not travel into Lake Erie. It was not possible to engineer a bypass of Niagara Falls with a series of locks due to the 100 m high Niagara escarpment. This escarpment obstacle to Niagara River navigation was overcome in 1829 with the completion of the first of four Welland Canals with locks 40 kilometers west of the Niagara River through the glacial till and alluvium that overlays the Niagara Escarpment. This permitted ocean going ships to enter Lake Erie and to continue on to Lake Michigan, Lake Huron and Lake Superior. The Eastern Great Lake shorelines, river banks and canals are actively eroding as a consequence of high surface water levels and flooding. The settlement of millions of people into the Eastern Great Lakes via the NYS Barge Canal and St. Lawrence Seaway migration pathways have created environmental and natural resource risks and challenges. These challenges and risks include deterioration of the Fourth Welland Canal and the need to replace it with the Fifth Welland Canal, industrial and urban wastewater disposal, shoreline, river bank and canal erosion as results of high water levels, the building of structures on the shoreline banks, invasive species and flooding.
The educational divide over feelings about ethnic minorities: does more education really lead to less prejudice?

ABSTRACT Virtually all studies on inter-ethnic attitudes in Western Europe and North America find that higher educated individuals report greater tolerance towards migrants and ethnic minorities. The overwhelming evidence on this link has even led scholars to call for educational expansion as a policy measure to increase social cohesion in today’s ever more diverse societies. But most of this evidence comes from cross-sectional correlations, and it is still unclear whether increasing education actually causes greater levels of tolerance. In this study, we follow a cohort of students aged 15 years over a period of 8 years from the German Children of Immigrants Longitudinal Survey (CILS4EU-DE). We focus on students who change from lower tracks into upper secondary and later tertiary education (the ‘treatment’ group) and compare them to a control group of similar students who stay in the lower track and leave school without entering university. Matching and fixed-effects panel regressions provide no evidence for a causal effect of changing into a higher educational track on subsequent prejudice towards ethnic minorities. We conclude that the descriptive difference between educational groups in their attitudes towards ethnic minorities is evident, but attending higher education per se does not seem to cause this difference.
THE RESILIENCE OF COMPLEX NETWORK: AN APPROACH FOR RELEVANT NODES EXTRACTION

In this paper, a new algorithm to select the relevant nodes — those that maintain the cohesion of the network — of the complex network is presented. The experiments on most of the real complex networks show that the proposed approach outperforms centrality measures as node degree, PageRank algorithm and betweenness centrality. The rationale of the algorithm for extracting relevant nodes is to discover the self-similarity of the network. As seen in the algorithm, throughout the extraction sequence of relevant nodes, differences are advised with node degree, PageRank algorithm and betweenness centrality. Finally, empirical evidence is considered to show that complex network robustness is a nonlinear function of the small-worldness measure.
Variation and prediction of different marsh landscapes in intertidal zone of the Yellow River Delta

Seven Landsat TM images during 1979—2013, combined with a field survey, were used to establish a database of tidal marshes in the Yellow River Delta, to determine the characteristics of landscape pattern in tidal marshes and the impacts of natural and human factors thereon. The trends of landscape patterns in tidal marshes in the future 20 years were also forecast using a Markov model. Results showed that the tidal marsh areas generally decreased from 1050.28 to 575.39
Evaluation of the Efficacy of Platelet Rich Plasma Injection in Chronic Lateral Epicondylitis

Background: Platelet-rich plasma helps in repair because of its growth factor. Platelet-rich plasma has been used in humans for its healing properties. Increased concentration of growth factors and secretory proteins may increase the process of healing on a cellular level. Aim: This study was done to check the effectiveness of PRP injections in patients with chronic lateral epicondylitis. Methodology: This was accomplished in patients visiting the orthopaedic OPD at the Sree Balaji Medical College and Hospital, Chennai, Tamilnadu. There were 40 physicians in this study, among whom 37 were homosexual and 87 were female. The mean age of the patients was 48.1 years (1782 years). The study period was 3 months. The analytical method used is a visual analog score. Results: Effective therapy was performed with a decline of more than 20% (24 out of 40 patients) in visual analog score after a dual-month period. After 3 months in boys, the mean VAS score dropped from 6.88 to 9.41. Conclusion: Medication of PRP patients with chronic epicondylitis or PRP tennis elbow reduces pain and increases the flexibility of the affected knee joint.
Genetic Variation of Rice Blast (Pyricularia oryzae) Isolates in Laos

The pathogenicity of 192 blast isolates collected from regions across the whole of Laos from 2007 to 2009 showed a wide variation in terms of the frequencies of virulence toward differential varieties (DVs) and the susceptible control cultivar Lijiangxintuanheigu. High frequencies of virulence (>50%) were found in the reactions of DVs for Pit, Pia, Pi3, Pi5(t), Pik-s, Piz-t, Pi19(t), and Pi20(t); intermediate values (from 10 to 50%) were found in DVs for Pib, Pii, Pik-m, Pi1, Pik-h, Pik, Pik-p, Pi7(t), Piz-5, Pita (two lines), Pita-2 (two lines), and Pi12(t); and low frequencies (<10%) were found in DVs for Pish, Piz, and Pi9(t). The blast isolates were classified into three cluster groups: Ia and Ib (low virulence) and II (high virulence), based on the patterns of reaction to them. The blast isolates in cluster group Ia were dominant in rainfed lowland areas, those in Ib were dominant in irrigated lowland areas, and those in II were dominant in upland areas. Cluster groups Ia, Ib, and II were dominant in the Southern, Central, and Northern regions, respectively. Blast races in Laos were distributed according to ecosystems for rice cultivation and geographical regions from south to north with different virulence. These isolates were categorized into 156 races, and the numbers of blast isolates were few in each race. A total of 15 representative isolates were selected from among them as standard differential blast isolates, to develop a differential system.
The importance of balance and postural control in the recovery of stroke patients

Abstract Introduction.According to the criteria of WHO, stroke is a health condition that causes focal or global brain disorders (1), but without an apparent nonvascular cause. Stroke is considered the third leading cause of death in industrialized countries and accounts for 9% of all deaths, being considered one of the largest cases of disability in the world. Due to the medical, social and economic consequences that it causes, stroke is considered a public health issue. Purpose of research. The study starts from the idea that in the recovery of stroke patients it is important to have an individualized physiotherapy program adapted to the functional parts of each patient, having the role of improving the static and dynamic balance, of achieving postural control and finally functional independence. Material and method. The study included a number of 22 patients with sequelae stroke. They made physiotherapy, occupational therapy and occupational therapy sessions in the ambulatory, with the length of 1 hour, 3 times a week, in total 15 sessions. The evaluation of the patient was performed in the beginning of the treatment and at the end of it. Scales were used to assess mobility, static and dynamic balance, gait and functional independence. Results. The application of individualized treatment adapted to the functional body of each patient allowed a rapid recovery for the vast majority of the studied patients. The values obtained in the tests and evaluation scales are in accordance with the clinical evolution of the patients. Conclusions.The application of the treatment by kinetic therapy, work therapy and occupational therapy to the 22 patients, for a period of 3 weeks pointed out the reduction of pain, the improvement of movements, the recovery of transfers and gait, the postural improvement.
Coordination of a remote mHealth infrastructure for atrial fibrillation management during COVID-19 and beyond: TeleCheck-AF

During the coronavirus 2019 (COVID-19) pandemic, outpatient visits for patients with atrial fibrillation (AF), were converted into teleconsultations. As a response to this, a novel mobile health (mHealth) intervention was developed to support these teleconsultations with AF patients: TeleCheck-AF. This approach incorporates three fundamental components: 1) “Tele”: A structured teleconsultation. 2) “Check”: An app-based on-demand heart rate and rhythm monitoring infrastructure. 3) “AF”: comprehensive AF management. This report highlights the significant importance of coordination of the TeleCheck-AF approach at multiple levels and underlines the importance of streamlining care processes provided by a multidisciplinary team, using an mHealth intervention, during the COVID-19 pandemic. Moreover, this report reflects on how the TeleCheck-AF approach has contributed to strengthening the health system in maintaining management of this prevalent sustained cardiac arrhythmia, whilst keeping patients out of hospital, during the pandemic and beyond.
Cellular recognition of microbial patterns through toll-like receptor (TLR) 2

Toll-like receptor (TLR) 2 mediates cellular recognition of microbial products. It has not been elucidated previously whether TLR2 binds its agonists directly or whether binding of an endogenous spaetzle-like ligand initiates receptor signaling as is exemplified by cell activation through the prototype TLR "toll" of Drosophila. We found by mutational analysis of the TLR2-ectodomain (ED) that distinct agonists utilize different subdomains of the TLR2-ED. Correspondingly, the TLR2-ED N-terminal third is excluded from TLR2-dependent cell activation by tri- and di-acylated bacterial lipopeptides but is involved in recognition of other TLR2 agonists. MAb T2.5 was found to antagonize both murine and human TLR2 and inhibited inflammatory reactions in systemic models of infection. Our data implicate binding of microbial products to specific epitopes of the TLR2-ED and mAb-mediated TLR-blockage for prevention of septic shock.
Effects of different levels of lespedeza and supplementation with monensin, coconut oil, or soybean oil on ruminal methane emission by mature Boer goat wethers after different lengths of feeding

ABSTRACT Mature Boer goat wethers were supplemented with 0.5% BW rolled corn and consumed pelleted alfalfa (CON), pelleted Sericea lespedeza (HSL; 6.4% condensed tannins), a 1:1 mixture of alfalfa and lespedeza (MSL), or alfalfa with monensin (ION; 22 mg/kg), coconut oil (CCO; 4%), or soybean oil (SBO; 4%). Total DM intake in the 20-wk study (3.86%, 3.75%, 3.52%, 3.69%, and 3.64% BW) and total tract OM digestibility determined every 5 wk (72.8%, 69.5%, 70.3%, 72.0%, and 71.1%) were not affected by treatment, although there were differences in nitrogen digestion (77.5%, 70.7%, 67.0%, 77.0%, 75.7%, and 73.6% for CON, MSL, HSL, ION, CCO, and SBO, respectively; SEM = 1.76). Ruminal methane emission was not influenced by period and was lowest among treatments for CON expressed as percentages of gross (10.3%, 6.8%, 6.3%, 7.2%, 6.5%, and 6.5%; SEM = 0.35) and digestible energy (14.8%, 10.2%, 9.3%, 10.6%, 9.8%, and 10.1% for CON, MSL, HSL, ION, CCO, and SBO, respectively; SEM = 0.62). In conclusion, both levels of lespedeza elicited similar depressions in ruminal methane emission, with a magnitude of change similar to that of an ionophore and coconut and soybean oils, and effects did not vary with week of the study.
Localization at the boundary for conditioned random walks in random environment in dimensions two and higher

We introduce the notion of \emph{localization at the boundary} for conditioned random walks in i.i. d. and uniformly elliptic random environment on $\mathbb{Z}^d$, in dimensions two and higher. Informally, this means that the walk spends a non-trivial amount of time at some point $x\in \mathbb{Z}^{d}$ with $|x|_{1}=n$ at time $n$, for $n$ large enough. In dimensions two and three, we prove localization for (almost) all walks. In contrast, for $d\geq 4$ there is a phase-transition for environments of the form $\omega_{\varepsilon}(x,e)=\alpha(e)(1+\varepsilon\xi(x,e))$, where $\{\xi(x)\}_{x\in \mathbb{Z}^{d}}$ is an i.i. d. sequence of random variables, and $\varepsilon$ represents the amount of disorder with respect to a simple random walk. The proofs involve a criterion that connects localization with the equality or difference between the quenched and annealed rate functions at the boundary.
Strong competitive effects of African savanna C4 grasses on tree seedlings do not support rooting differentiation

Abstract: Rooting differentiation between established trees and grasses has been well documented in savannas, but it remains unclear to what extent tree-grass rooting differences affect competition between newly established seedlings and grasses. To examine this question, a greenhouse experiment was conducted at the University of Missouri, USA. Twenty 3-mo-old seedlings each of two African savanna tree species (Acacia nigrescens and Colophospermum mopane) were grown for 8 mo with two crossed factors: grass competition and irrigation depth. Strong negative effects of grass competition on final seedling biomass and leaf photosynthetic and stomatal conductance occurred in both tree species, but no effects of irrigation depth were detected. There was a clear tree species by grass competition interaction, suggesting interspecific variation in competitive response. The results emphasize the importance of below-ground competition with grasses for physiological and morphological responses of tree seedlings, while minimizing the importance of tree-grass rooting depth differences as a factor in modulating the competitive response of trees to grasses at the seedling stage.
Transfer Learning Based Activity Recognition using ResNet 101 C-RNN Model

As we know traditional passive video surveillance systems are inefficient and error prone, as they need human eye for analysis of recorded data. Automatic Human Activity Recognition is currently receiving an increasing consideration from computer vision scientists with the goal of an automated analysis of ongoing activities from video streams. This interest is inspired by its applications over a widespread field such as smart surveillance systems, border crossings, health care systems, robot learning etc. Deep networks allow building such intelligent surveillance systems with automated feature learning. But large volume of data is required for sufficient network training, which in-turn demands for more computational resources to conduct network training. There is strong need for solutions that can better exploit available data and require minimal training and preprocessing. This paper investigates the use of the CNN and ResNet 101 model known as C-RNN architecture for activity recognition from video streams using transfer learning. The proposed approach is prepared and approved on well-known UCF-101 dataset based on accuracy and average loss which gives preferred outcomes over state-of-art methods. This approach gives impressive performance and great potential for computer vision.
Childhood maltreatment and later stressful life events as predictors of depression: A test of the stress sensitization hypothesis.

Objectives Long-term negative effects of child maltreatment, including risk for depression, are well established. The role of acute stressors in the relationship between maltreatment and depression is not as clear. We used data from a prospective study to test a stress sensitization hypothesis; whether child maltreatment lowered the threshold at which adult household stressors impacted adult depression. We hypothesized that maltreatment would positively moderate the relationship between acute stressors and adult depressive symptoms. Method Participants (n = 457) were majority White (~ 80%) and from low-income families (63%), and the sample was gender balanced (54% male) at the start of a 40-year longitudinal study examining the causes and consequences of child maltreatment. Regression analyses tested a main effects model for adult depression, modeled as a function of proximal adult household stressors and officially recorded child maltreatment, and controlled for measures of prior depression, household stress, and sociodemographic factors. A second model added the interaction between maltreatment and stressors to test the stress sensitization hypothesis. Results Maltreatment had a positive overall association with adult depression. This association was not significant after taking into account adult stressors and other controls. Adult stressors had a unique, positive association with depression. The association between adult stressors and depression was stronger for participants with histories of child maltreatment. Conclusions Child maltreatment increases sensitivity to later stressors, adding to the risk for depression. Findings are generally consistent with prior studies linking child maltreatment, stress, and later depression and provide support for stress sensitization extending into adulthood.
Apple rootstocks may become infected by Neonectria ditissima during propagation

ABSTRACT Introduction and purpose: The ability of apple rootstocks to become infected by Neonectria ditissima, the cause of European canker, was studied over two years. Materials and methods: Rootstocks B9 and M9 with a size suitable for grafting (6-10 mm stem diameter, termed rootstocks), and smaller sized rootstocks (<5 mm stem diameter, termed transplants) of B9, M9, M26, MM106 and Antonovka were inoculated with N. ditissima at different times, either with contaminated map pins or with spore suspensions. In addition, the rootstocks were either defeathered (side shoots removed), topped (top shoot headed) or both, to create wounds that would normally occur during propagation, while wounds on transplants were made by removing leaves. Results and discussion: One month after inoculation, slightly sunken canker lesions had developed around the inoculation points of the map pins or wounds. No lesions developed on the non-inoculated controls. Map pin inoculation resulted in 30% to 89% infection and spore suspension sprayed on wounds from 5% to 45% infection. When the cankered areas were split open, brown lesions with necrotic tissue due to infection by N. ditissima appeared. The transplants of M9, M26 and MM106 inoculated with contaminated map pins in 2014 developed necrosis on 40% to 67% of the plants, but there were no differences in the incidence or severity among the different types. On the transplants of B9, Antonovka and M9 inoculated in 2015, there was more necrosis on B9 (42%) than on Antonovka (11%) and more sporulating lesions on B9 (29%) than on M9 (9%) or on Antonovka (4%). Conclusion: It can be concluded that rootstocks used for apple trees may become infected by N. ditissima, and wounds should thus be protected during propagation.