Miracle-dz/UniFAR-FTUs huggingface dataset:
The Anti-Apoptotic, Anti-Inflammatory And Anti- Oxidant Effects Of Olmesartan On Renal I/R Injury In Male Rat Model

Background: Ischemia reperfusion injury (IRI) is considered the main important factor that determined the morbidity and mortality in many disorders as example acute kidney injury (AKI), myocardial infarction (MI), ischemic stroke and sepsis. In certain situations as major surgery and organ transplantation, IRI is considered the main challenge that affected on healing and clinical outcomes. During ischemia, there is reduction in blood supply to ischemic organ and this will lead to poorly supply of oxygen (hypoxia) and nutrients and decrease the discharge of metabolic waste products and so will lead to accumulate carbon dioxide (CO2) and other debris. Severe ischemia and hypoxia for long time lead to micro-vascular changing in structure and dysfunction. When the ischemic tissue is reperfused by rapidly new blood that rich in oxygen and nutrient this will lead to micro vascular injury that is occur due to increase vascular permeability and leakage of fluid and protein from the capillaries to tissues lead to edema and damage. Also when the rapidly reperfusion occurred by highly oxygenated and nutrient blood to ischemic or damaging tissues lead to releasing of reactive oxygen species (ROS) from endothelial layer of capillaries and potentiate the inflammatory process and releasing of inflammatory mediators and factors such as tumor necrosis factor alpha (TNF-α), interferon gamma, interleukin 6 (IL-6), and interleukin-1β (IL1β)and also releasing matrix metalloproteinase 9 enzyme (MMP9), complement protein and inflammatory or immunity cells as Neutrophil, macrophage, lymphocyte and others. Objective: This experimental research is done to investigate the possible Nephroprotective effect of Olmesartanon bilateral renal I/R injury in male rats through determining several renal function biomarkers as U & C, several inflammatory mediators as TNFα and MMP-9, antioxidant markers as TAC, several apoptotic markers as BCL-2 and BAX and also through histopathology scores. Materials and Method: In this study, 20 adult Wister Albino rats were used with 20-24 weeks in age and weighing 200-350 g. The adult rats were divided randomly into equal 4 groups (5 rats in each group) as the following: 1. Sham group: All 5 rats underwent the same anesthetic and surgical procedures for an identical period of time for ischemia and reperfusion without ischemia reperfusion induction. Renal tissues and blood samples were collected. 2. Control group: All 5 rats underwent median laparotomy under anesthesia, followed by 30min bilateral renal ischemia, and then renal tissues and blood samples were collected after 2h of reperfusion. 3. Vehicle group: All 5 rats pretreated with intraperitoneally injection of DMSO 30 min before ischemia reperfusion injury and undergo bilateral renal ischemia for 30 min and reperfusion for 2 hours. 4. Olmesartan treated group: All 5 rats were pretreated with by intraperitoneally injection of Olmesartan 10 mg/kg 30 min before ischemia reperfusion injury and undergo bilateral renal ischemia for 30 min and reperfusion
Characterizing Plug-in Hybrid Electric Vehicle Consumers Who Found the U.S. Federal Tax Credit Extremely Important in Enabling Their Purchase

Problem. The U.S. federal tax credit (FTC) for the adoption of plug-in electric vehicles (EVs) provides up to $7,500 to reduce the costs of acquisition—a potentially powerful enabler. A phase-down process is triggered once an automaker sells 200,000 EVs, initially leading to the halving of the FTC, followed by a subsequent halving, and ultimately to the elimination of the credit for all vehicles that automaker sells [1]. FTC phase out (elimination) occurred for Tesla vehicles at the end of 2019 and is occurring for GM vehicles at the end of March 2020. Who has found the FTC most influential? What will the effects of FTC phase-out be? Assessment of who the FTC has influenced can calibrate expectations and inform discussions about optimal policies moving forward.
EVALUATION OF DOCETAXEL USE IN NON-SMALL CELL LUNG CANCER: REAL-WORLD HEALTH OUTCOMES

Chemotherapy agents such as docetaxel are still used after failure of first or second-line immunotherapy. In order to establish the ideal choice of treatment, it is necessary to compare the efficacy and safety in the real-world setting between the available schemes. We performed a retrospective, observational study in a referral hospital including patients treated with docetaxel for non-small cell lung cancer between January 2013 and June 2017. Effectiveness variables included overall survival (OS) and progression free survival (PFS). The safety variable was the incidence of adverse events (AE). 91 patients were enrolled (84.6% men) with a mean age of 63.6 years. 21 patients were treated with a combination of docetaxel + nintedanib, and the rest with monotherapy. 79.1% of patients presented AEs of any grade and treatment had to be delayed or discontinued in 10%. The median PFS was 2.8 months (95% CI 2.3-3.3) and for OS, 6.9 months (95% CI 4.9-8.8). In adenocarcinoma patients no difference in OS was observed between monotherapy with docetaxel vs. docetaxel + nintedanib. Overall results are similar to clinical trials, but not when nintedanib is added to the therapy.
The Statutory Minimum Wage in Germany and the Labor Demand Elasticities of Low-Skilled Workers: A Regression Discontinuity Approach with Establishment Panel Data

This study examines the influence of the statutory minimum wage on labor demand elasticities regarding low-skilled workers. For this, a regression discontinuity analysis is conducted using company panel data from 2013 to 2018. In addition, a possible endogeneity of the remuneration for low-skilled workers was considered using an IV estimation. It is shown that the monopsonistic structures of the labor market may continue to exist after the introduction of the minimum wage. Additionally, the own-wage elasticity for low-skilled workers did not change over the period considered. However, in the short run, stronger substitutive relationships with medium-skilled workers seem to exist, and probably also with highly qualified employees in the long run.
Generating patterns on clothing for seamless design

Symmetric patterns are used widely in clothing manufacture. However, the discontinuity of patterns at seams can disrupt the visual appeal of clothing. While it is possible to align patterns to conceal such pattern breaks, it is hard create a completely seamless garment in terms of pattern continuity. In this thesis, we explore computational methods to parameterize the clothing pieces relative to a pattern’s coordinate system to achieve pattern continuity over garments. We review previous work related to pattern alignment on clothing. We also review surface quadrangulation methods. With a suitable quadrangulation, we can map any planar pattern with fourfold rotations into each quad, and achieve a seamless design. With an understanding of previous work, we approached the problems from three angles. First, we mapped patterns with sixfold rotations onto clothing by triangulating the clothing pieces and ensuring consistency of triangle vertices on both sides of a seam. We also mapped patterns with fourfold rotations onto clothing by optimizing the shape of each clothing piece in the texture domain. Lastly, we performed quadrangulation guided by cross fields, and mapped fourfold pattern units into each quad. We assembled and simulated the texture mapped clothing in Blender to visualize the results.
A Flexible Reinforced Bin Packing Framework with Automatic Slack Selection

The slack-based algorithms are popular bin-focus heuristics for the bin packing problem (BPP). The selection of slacks in existing methods only consider predetermined policies, ignoring the dynamic exploration of the global data structure, which leads to nonfully utilization of the information in the data space. In this paper, we propose a novel slack-based flexible bin packing framework called reinforced bin packing framework (RBF) for the one-dimensional BPP. RBF considers the RL-system, the instance-eigenvalue mapping process, and the reinforced-MBS strategy simultaneously. In our work, the slack is generated with a reinforcement learning strategy, in which the performance-driven rewards are used to capture the intuition of learning the current state of the container space, the action is the choice of the packing container, and the state is the remaining capacity after packing. During the construction of the slack, an instance-eigenvalue mapping process is designed and utilized to generate the representative and classified validate set. Furthermore, the provision of the slack coefficient is integrated into MBS-based packing process. Experimental results show that, in comparison with fit algorithms, MBS and MBS’, RBF achieves state-of-the-art performance on BINDATA and SCH_WAE datasets. In particular, it outperforms its baseline MBS and MBS’, averaging the number increase of optimal solutions of 189.05% and 27.41%, respectively.
Phenomenological Evaluation on Wayfinding in Complex Educational Buildings: The Case of ITU Faculty of Architecture

JCoDe | Vol 2 No 1 | March 2021 | Measuring in Design | Çavuş, Ö. Orientation programs have a significant role in the adaptation of novice students to the faculty building. These programs are mostly prepared by faculty staff or authority figures who have already known the building, so they may not descend to those inexperienced in the faculty. Even if students are informed about the places in these programs, it can still be hard to find places, particularly in complex educational buildings, until they get used to them. Hence, experience-based approaches facilitating wayfinding are needed to cope with the problem. This research aims to reveal the reasons for confusion and reference points students take in wayfinding through phenomenological evaluation of the building. Istanbul Technical University (ITU) Faculty of Architecture is selected as a case study due to its complexity in wayfinding. A head-mounted GoPro is placed to twenty novice students and ten senior students as a control group, and students are asked to find a target point and return to the initial point following the shortest path. The obtained results are then evaluated according to the measuring techniques proposed by Moles (2004) since the measurement needs to answer ill-defined situations obtained from experiences. The visual recordings of participants are compared regarding the architectural mass. Therefore, comparison and equality judgment, contrast or antinomy, and weight coefficient techniques are particularly utilized among the provided techniques. Beyond the expected data, the results of the study provide information about the factors, methods, and priorities that are effective in decision making. This research would contribute to the literature showing how the data set is created based on users' direct experience in wayfinding in complex educational buildings. Phenomenological Evaluation on Wayfinding in Complex Educational Buildings: The Case of ITU Faculty of Architecture
Electrooxidation of Zolpidem and its Voltammetric Quantification in Standard and Pharmaceutical Formulation using Pencil Graphite Electrode

In this study a new, simple, precise, accurate and economic electrochemical method was developed and validated for the voltammetric determination of zolpidem (ZP) using disposable pencil graphite (PG) electrode. The anodic oxidation of ZP on the surface of the PG electrode was examined in a britton robinson (BR) buffer. Square wave and cyclic voltammetry were used as electrochemical techniques in the potential range of 0-1.2 V in the pH 8 BR buffer. In cyclic voltammetry studies, the diffusion coefficient of ZP oxidation was found to be 3.6 × 10 -6 cm 2 s -1 . On the other hand, the ZP has shown a well-defined irreversible anodic peak at 0.98 V in the square wave voltammetry mode. The PG electrode, primarily being graphite which has a large active surface area gives rise to increasing peak current with respect to ZP electrooxidation. PG electrode showed an electrocatalytic effect in anodic oxidation of ZP. A linear relationship between catalytic current response and ZP concentration was obtained over a concentration range of 10-30 µ M with R.S. D. values ranging from 0.29 -3.89. Limits of detection and quantitation were found to be 1 and 3 µ M, respectively. Finally, the PG electrode was successfully used to determine ZP in standard and tablet dosage forms with a mean recovery of 100.69 %.
We Spoke Different Languages , Yet We Sang The Same Song ” : An Analysis Of Multiculturalism In Ola Bola

This study explores the portrayal of multiculturalism in the film, Ola Bola. In addition, the study also investigates the success behind the movie . The content analysis methodology based research utilised Structuralist Film Theory to write the analysis. Besides analysing the film, the researcher also analysed blogs and online portals to gather opinions from various perspectives. From the findings, a total of five themes (interracial friendship, cross cultural interaction, multilingual dialogues, portrayal of minority community and embracing colour blindness) were gauged from the analysis. As for the success of this film, it was found that marketing and promotion campaigns were the main reasons for Ola Bola to perform well at the box office. From the analysis done on blogs and portals it was found that most Malaysians enjoyed multicultural films, and they also hoped for Malaysians to stay united.
Physical Flood Vulnerability Assessment using Geospatial Indicator-Based Approach and Participatory Analytical Hierarchy Process: A Case Study in Kota Bharu, Malaysia

The most devastating flood event in Kota Bharu was recorded in December 2014, which affected several properties worth millions of dollars and thousands of homes. Damage to physical properties, especially buildings, is identified as a significant contributor to flood disasters in Malaysia. Therefore, it is essential to address physical flood vulnerability by developing an integrated approach for modeling buildings’ flood vulnerability to decrease the flood consequences. This study aims at developing a flood vulnerability assessment approach using an indicator-based model (IBM) for individual buildings in Kota Bahru, Kelantan, Malaysia. An intensive literature review and expert opinions were used to determine suitable indicators that contribute to the physical flood vulnerability of buildings. The indicators were grouped into three components, i.e., flood hazard intensity (I), building characteristics (C), and effect of the surrounding environment (E). The indicators were further refined based on expert opinions and Relative Importance Index (RII) analysis. Based on their contribution to the Malaysia local building flood vulnerability, priority weight is assigned by the experts to each of the selected indicators using the participatory Analytical Hierarchy Process (AHP). A spatial database of buildings in Kota Bharu is developed through field surveys and manually digitizing building footprints from satellite imageries. The identified indicators and their weight are added to each building footprint. The Weighted Linear Combination (WLC) aggregation method combined the weight of indicators into a vulnerability index and maps. The results of a physical flood vulnerability were validated using building damage information obtained through interviews with the community that experienced previous flood in the study area. The result showed that about 98% of the study area’s buildings have either moderate or low vulnerability to flooding. The flood vulnerability map has an overall accuracy of 75.12% and 0.63 kappa statistics. In conclusion, the IBM approach has been used successfully to develop a physical flood vulnerability for buildings in Kota Bharu. The model contributes to support different structural and non-structural approaches in the flood mitigations process.
A COMPARISION OF ANTIOXIDANT CAPACITIES OF ETHANOL EXTRACTS OF SATUREJA HORTENSIS AND ARTEMISIADRACUNCULUS LEAVES

Summary Satureja hortensis (Lamiaceae family) and Artemisia dracunculus (Asteraceae family) are both used as home remedies in Iran. Due to the fact that some species of Asteraceae family have proven to contain potential antioxidant capacities, present study was designed to evaluate and compare the antioxidant capacities of ethanolic extracts of S. hortensis and A. dracunculus leaves using in vitro assays such as DPPH and ABTS along with ferric reducing antioxidant power (FRAP). In addition, total flavonoid and phenolic contents of both extracts were measured. Results showed that S. hortensis has the ability of scavenging ABTS and DPPH radicals as well as reducing ability for ferric iron ions in a dose dependent manner much better than A. dracunculus. Based on our data, it can be concluded that S. hortensis, as a natural rich source of antioxidants, could be evaluated for probable pharmaceutical application in prevention of many free radical-associated diseases.
Metal Uptake, Growth Responses, and Chlorophyll Production of Wheat ( Triticum aestivum ) Exposed at Different Durations to Chelate-Amended Cadmium-Contaminated Soils

Phytoextraction is gaining acceptance as a cost-effective and environmentally sound phytoremediation strategy for reducing toxic metal levels from contaminated soils. We hypothesized that the addition of synthetic chelates can increase the amount of bioavailable metal for root uptake, thereby improving the efficacy of phytoextraction. This study was conducted to evaluate the effects of Cadmium (Cd) and ethylenediaminetetraacetic (EDTA) on the growth, metal uptake, and chlorophyll (Chl) production in wheat plants. Wheat (Triticum aestivum L. cv TAM-109) seeds were planted in plastic tubes containing topsoil and peat (2:1, v: v) spiked with various levels (0, 250, 500 mg Cd/kg dry soil) of cadmium nitrate. After 30, 45, and 60 days of growth, plants were harvested. Results show that after 60 days, wheat biomass was greater at 100, 250, and 500 mg/kg of Cd-treated soil without the addition of EDTA as compared to plants grown in Cd-treated soil plus EDTA. Although Chl production generally decreased with increased exposure time and Cd concentration, we nonetheless observed Chl production to be higher during each harvesting period in plants exposed to Cd plus EDTA. Treatments with the highest Chl concentration occurred on day 30.
Real-Time Communication Approach in Wireless Sensor Networks Applied for Smart Home

Summary In this paper, we propose a Real-Time Communication Tree Building approach (RT-CTB) for critical Sensor Networks (WSN). This approach aims to provide communications between sensor nodes that respect of real-time constraints with the prediction of the communication delays as well as improving the Sensors Network Lifetime (SNL) of these networks in order to have maximum longevity. The building of the real-time communication trees is done periodically depending on the load and the remains energy in each sensor. This approach is applied for Smart Home where the existence of the events that require that the information should reach the base station before the delay such as the fire. The simulation results show that our RT-CTB approach is better than non-real time approaches. We have compared our results to other works and we have proved the efficiency of our approach in terms of energy and delay.
NBER WORKING PAPER SERIES AGGREGATE IMPLICATIONS OF BARRIERS TO FEMALE ENTREPRENEURSHIP

We develop a framework for quantifying barriers to labor force participation (LFP) and entrepreneurship faced by women in developing countries, and apply it to the Indian economy. We find that women face substantial barriers to LFP. The costs for expanding businesses through the hiring of workers are also substantially higher for women entrepreneurs. However, there is one area in which female entrepreneurs have an advantage: the hiring of female workers. We show that this is not driven by the sectoral composition of female employment. Consistent with this pattern, we find even without explicitly targeting female LFP, policies that boost female entrepreneurship can significantly increase female LFP. Counterfactual simulations indicate that removing all excess barriers faced by women entrepreneurs would substantially increase the fraction of female-owned firms, female LFP, earnings, and generate substantial gains for the economy. These gains are due to higher LFP, higher real wages and profits, and reallocation: low productivity male-owned firms previously sheltered from female competition are replaced by higher productivity female-owned firms previously excluded from the economy. Gaurav Chiplunkar University of Virginia 100, Darden Blvd. Charlottesville, VA 22905 chiplunkarg@darden.virginia. edu Pinelopi K. Goldberg Yale University Department of Economics 37 Hillhouse Ave. P.O. Box 208264 New Haven, CT 06520-8264 and NBER penny.goldberg@yale.edu
Clinical Correlates of Physiochemical Changes in Urinary Composition in Subjects treated with Cymbopogon citratus infusion

Previous studies have shown that the physiochemical properties of urine could change after ingestion of medicinal plants, and may provide significant clinical and diagnostic information. This study examined the urinary profile of healthy subjects who consumed Cymbopogon citratus (C. citratus) infusion. Urine samples were obtained from 105 participants at days 0, 10 and 30 after treatment with infusions prepared from 2, 4 and 8g of C. citratus powder. Biochemical analyses of the urine to determine its chemical constituents were performed using standard procedures. Results obtained on days 10 and 30 were compared with baseline values. UV and UF increased in all groups. Urinary excretion of some electrolytes (Na + and K + ) and DA increased at day 10 only, whereas others (Ca 2+ and Cl ) increased at both days 10 and 30. USG and colour remained unchanged. Urinary creatinine levels significantly increased (p<0.05) in all groups, whereas urinary urea significantly (p<0.05) increased in all groups except the group treated with 8g for 30 days. Urine uric acid and pH decreased in all groups. Urinary protein, glucose, bilirubin and bicarbonate were undetected. Ingestion of C. citratus infusion is associated with some physiochemical changes in urinary composition and could provide significant clinical information on the systemic effects of the plant in humans. © 2014 Elixir All rights reserved ARTIC LE INF O Article h istory: Received: 25 January 2014; Received in revised form: 22 February 2014; Accepted: 1 March 2014;
MODELLING AND IMPLEMENTATION OF MACHINE LEARNING TECHNIQUES FOR HATE SPEECH DETECTION IN MOBILE APPLICATIONS

: The proliferation of data through various platforms and applications is in constant increase. The versatility of data and its omnipresence makes it very hard to detect the trustworthiness and intention of the source. This is very evident in dynamic environments such as mobile applications. As a result, designing mobile applications that will monitor, control and block any type of malintents is important. This paper makes an attempt in this direction by implementing a lightweight machine learning classification scheme for hate speech detection in Albanian Language for mobile applications. Initial testing and evaluations indicate good classifier accuracy in mobile environments where frequent and realtime training of the algorithm is required.