Miracle-dz/UniFAR-FTUs huggingface dataset:
Mastic gum aided amoxicillin trihydrate gastro retentive mucoadhesive microspheres: In vivo evaluation

The primary objective of the study is to test gastro retentive mucoadhesive Amoxicillin trihydrate (ATH) microspheres for various in vivo properties. Several metrics were used to assess the improved ATH Mastic gum mucoadhesive microspheres (AMMM) in vitro. In vivo testing was conducted using formula-8 (AMMM-8), as suggested by prior study results by Soujanya et al., 2022. Four healthy rabbits of both sexes were used to assess the availability of plasma medicines. Pharmacokinetic parameters were measured in plasma samples. The study revealed that in vivo animal studies in rabbits showed good drug levels of ATH. After a single dose of formulation AMMM-8 (44.28mg/kg), the symmetrical mean Cmax (25.69±0.11μg/ml) tmax (6h), AUC (0-10h) (185.1±1.28 μg.h/ml), AUC (0-∞) (269.1±4.68 μg.h/ml), and AUMC (840.42±2.23 μg.h/ml) were better than ATH. According to the findings, ATH reached systemic circulation faster than the pure medication and had acceptable kinetic values. Bangladesh J. Sci. Ind. Res. 57(3), 187-194, 2022
New limits on coupled dark energy from Planck

Recently, the Planck collaboration has released the first cosmological papers providing the high resolution, full sky, maps of the cosmic microwave background (CMB) temperature anisotropies. It is crucial to understand that whether the accelerating expansion of our universe at present is driven by an unknown energy component (Dark Energy) or a modification to general relativity (Modified Gravity). In this paper we study the coupled dark energy models, in which the quintessence scalar field nontrivially couples to the cold dark matter, with the strength parameter of interaction β. Using the Planck data alone, we obtain that the strength of interaction between dark sectors is constrained as β < 0.102 at 95% confidence level, which is tighter than that from the WMAP9 data alone. Combining the Planck data with other probes, like the Baryon Acoustic Oscillation (BAO), Type-Ia supernovae ``Union2.1 compilation'' and the CMB lensing data from Planck measurement, we find the tight constraint on the strength of interaction β < 0.052 (95% C.L.). Interestingly, we also find a non-zero coupling β = 0.078±0.022 (68% C.L.) when we use the Planck, the ``SNLS'' supernovae samples, and the prior on the Hubble constant from the Hubble Space Telescope (HST) together. This evidence for the coupled dark energy models mainly comes from a tension between constraints on the Hubble constant from the Planck measurement and the local direct H0 probes from HST.
Constraints on the star-formation rate of z ~ 3 LBGs with measured metallicity in the CANDELS GOODS-South field

We analyse 14 LBGs at z~2.8-3.8 constituting the only sample where both a spectroscopic measurement of their metallicity and deep IR observations (CANDELS+HUGS survey) are available. Fixing the metallicity of population synthesis models to the observed values, we determine best-fit physical parameters under different assumptions about the star-formation history and also consider the effect of nebular emission. For comparison we determine the UV slope of the objects, and use it to estimate their SFR_UV99 by correcting the UV luminosity following Meurer et al. (1999). A comparison between SFR obtained through SED-fitting (SFR_fit) and the SFR_UV99 shows that the latter are underestimated by a factor 2-10, regardless of the assumed SFH. Other SFR indicators (radio, far-IR, X-ray, recombination lines) coherently indicate SFRs a factor of 2-4 larger than SFR_UV99 and in closer agreement with SFR_fit. This discrepancy is due to the solar metallicity implied by the usual beta-A1600 conversion factor. We propose a refined relation, appropriate for sub-solar metallicity LBGs: A1600 = 5.32+1.99beta. This relation reconciles the dust-corrected UV with the SED-fitting and the other SFR indicators. We show that the fact that z~3 galaxies have sub-solar metallicity implies an upward revision by a factor of ~1.5-2 of the global SFRD, depending on the assumptions about the age of the stellar populations. We find very young best-fit ages (10-500 Myrs) for all our objects. From a careful examination of the uncertainties in the fit and the amplitude of the Balmer break we conclude that there is little evidence of the presence of old stellar population in at least half of the LBGs in our sample, suggesting that these objects are probably caught during a huge star-formation burst, rather than being the result of a smooth evolution.
Sensitivity of Inner Spacer Thickness Variations for Sub-3-nm Node Silicon Nanosheet Field-Effect Transistors

The inner spacer thickness (TIS) variations in sub-3-nm, node 3-stacked, nanosheet field-effect transistors (NSFETs) were investigated using computer-aided design simulation technology. Inner spacer formation requires a high selectivity of SiGe to Si, which causes inevitable TIS variation (ΔTIS). The gate length (LG) depends on the TIS. Thus, the DC/AC performance is significantly affected by ΔTIS. Because the effects of ΔTIS on the performance depend on which inner spacer is varied, the sensitivities of the performance to the top, middle, and bottom (T, M, and B, respectively) ΔTIS should be studied separately. In addition, the source/drain (S/D) recess process variation that forms the parasitic bottom transistor (trpbt) should be considered with ΔTIS because the gate controllability over trpbt is significantly dependent on ΔTIS,B. If the S/D recess depth (TSD) variation cannot be completely eliminated, reducing ΔTIS,B is crucial for suppressing the effects of trpbt. It is noteworthy that reducing ΔTIS,B is the most important factor when the TSD variation occurs, whereas reducing ΔTIS,T and ΔTIS,M is crucial in the absence of TSD variation to minimize the DC performance variation. As the TIS increases, the gate capacitance (Cgg) decreases owing to the reduction in both parasitic and intrinsic capacitance, but the sensitivity of Cgg to each ΔTIS is almost the same. Therefore, the difference in performance sensitivity related to AC response is also strongly affected by the DC characteristics. In particular, since TSD of 5 nm increases the off-state current (Ioff) sensitivity to ΔTIS,B by a factor of 22.5 in NFETs, the ΔTIS,B below 1 nm is essential for further scaling and yield enhancement.
Reduktion von diabetesbezogenem Distress bei Typ-1- und Typ-2-Diabetes durch eine kognitiv-verhaltenstherapeutische Gruppenintervention

Zusammenfassung Das Stresserleben durch die Erkrankung Diabetes mellitus stellt für einen Großteil der betroffenen Personen oft eine deutliche Belastung dar, die sich negativ auf das Diabetes-Selbstmanagement und damit auf die Gesundheit der Betroffenen auswirken kann. Das Ziel der vorliegenden Studie war die Evaluation einer diabetesspezifischen kognitiv-verhaltenstherapeutischen Gruppentherapie zur Reduktion des Stresserlebens, bestehend aus sechs Sitzungen für Personen mit Typ-1- oder Typ-2-Diabetes. Vermittelt wurden Techniken zur Stressbewältigung, wie Achtsamkeit und Entspannungsübungen, sowie kognitive Techniken, die auf den Alltag mit der Diabeteserkrankung und damit verbundene Gedanken und Emotionen der Teilnehmenden bezogen waren. Von 52 Personen (51,9% mit Typ-1-Diabetes, 61,5% weiblich, Alter MW= 50,4 Jahre) lagen nach Studienteilnahme Fragebögen vor. Eine signifikante Verbesserung konnte im Problem Areas In Diabetes Questionnaire (Δ6.24 [95%-KI: 1.85–10.62], p=.006), dem Perceived Stress Survey (Δ2.93 [95%-KI: 1.59–4.26], p=.000) und der Diabetes Acceptance Scale (Δ5.5 [95%-KI: 9.07–1.93], p=.003) erreicht werden. Diese erwies sich auch im Follow-Up nach sechs Monaten als stabil. Der selbstberichtete HbA1c-Wert reduzierte sich im Befragungszeitraum bei der Teilstichprobe von N= 40, von der die Daten verfügbar waren, ebenfalls signifikant (Δ0.73 [95%-KI: 0.015–1.452], p=.046). Das Gruppentherapieprogramm zur Stressreduktion kann als eine niedrigschwellige, psychotherapeutische Interventionen zur Reduktion diabetesbezogener Belastungen angesehen werden. Es könnte ein hilfreiches primär- und sekundärpräventives Angebot für stressbelastete Menschen mit Diabetes in der Standardversorgung darstellen.
Phase diagram of the XXZ ferrimagnetic spin-(1/2, 1) chain in the presence of transverse magnetic field

We investigate the phase diagram of an anisotropic ferrimagnetic spin-(1/2, 1) in the presence of a non-commuting (transverse) magnetic field. We find a magnetization plateau for the isotropic case while there is no plateau for the anisotropic ferrimagnet. The magnetization plateau can appear only when the Hamiltonian has the U(1) symmetry in the presence of the magnetic field. The anisotropic model is driven by the magnetic field from the Néel phase for low fields to the spin-flop phase for intermediate fields and then to the paramagnetic phase for high fields. We find the quantum critical points and their dependence on the anisotropy of the aforementioned field-induced quantum phase transitions. The spin-flop phase corresponds to the spontaneous breaking of Z2 symmetry. We use the numerical density matrix renormalization group and analytic spin wave theory to find the phase diagram of the model. The energy gap, sublattice magnetization and total magnetization parallel and perpendicular to the magnetic field are also calculated. The elementary excitation spectra are obtained via the spin wave theory in the three different regimes depending on the strength of the magnetic field.
The Distinctive Activation of Toll-Like Receptor 4 in Human Samples with Sepsis

Clinical success of Toll-Like receptor-4 (TLR-4) antagonists in sepsis therapy has thus far been lacking. As inhibition of a receptor can only be useful if the receptor is active, stratification of patients with active TLR-4 would be desirable. Our aim was to establish an assay to quantify phosphorylated TLR-4 using the proximity ligation assay (PLA). HEK293 TLR4/MD2/CD14 as well as THP-1 cells were stimulated with LPS and the activation of TLR-4 was measured using the PLA. Furthermore, peripheral blood mononuclear cells (PBMCs) from 25 sepsis patients were used to show the feasibility of this assay in clinical material. Activation of TLR-4 in these samples was compared to the PBMCs of 11 healthy individuals. We could show a transient activation of TLR-4 in both cell lines. Five min after the LPS stimulation, the signal increased 6.7-fold in the HEK293 cells and 4.3-fold in the THP-1 cells. The assay also worked well in the PBMCs of septic patients. Phosphorylation of TLR-4 at study inclusion was 2.9 times higher in septic patients compared to healthy volunteers. To conclude, we established a diagnostic assay that is able to quantify the phosphorylation of TLR-4 in cell culture and in clinical samples of sepsis patients. This makes large-scale stratification of sepsis patients for their TLR-4 activation status possible.
Building Energy Simulation Model Application to Greenhouse Microclimate, Covering Material and Thermal Blanket Modelling: A Review

This review documents the present knowledge and knowledge gap in applying building energy simulation (BES) dynamic models to greenhouses. The focus of this review is to compile the literature on the BES dynamic model of greenhouse microclimate, covering materials, energy requirements and thermal blankets using the Transient System Simulation version 18 (TRNSYS 18) software. Fifty-two journal articles, mostly Science Citation Index (SCI) and Scopus index journals, on BES development and simulation of greenhouse microclimate, greenhouse energy requirement, covering materials and thermal blankets were reviewed. These researchers sought to optimise greenhouse crop production. The main features of the TRNSYS 18 software for BES development are outlined; each research consulted for this review successfully developed, simulated and validated its BES. However, none of these developed models included the vapour pressure deficit (VPD) as a greenhouse microclimate factor, an essential climate parameter. In conclusion, this study demonstrates that applying a BES developed using TRNSYS has excellent potential to optimise greenhouse crop production and help adapt appropriate climate control strategies and energy-saving techniques. However, it is recommended to include VPD in future BES model development.
Measurement Invariance of the Emotion Regulation Questionnaire for Children and Adolescents in Chinese and American Adolescents Samples

To establish the factor structure of the Emotion Regulation Questionnaire for Children and Adolescents (ERQ-CA) in Chinese and American adolescent samples; to assess measurement invariance of the ERQ-CA in Chinese and American adolescent samples and latent means across early adolescents from two diverse cultural settings. The ERQ-CA was administered to 1221 Chinese adolescents (49.3% males) and 1148 American adolescents (50.1% males), and multi-group confirmatory factor analysis was performed to evaluate measurement invariance. (1) Multi-group confirmatory factor analysis of the ERQ-CA demonstrated full configural invariance, full metric invariance, partial scalar invariance, and partial strict invariance. (2) The latent variable mean comparisons revealed significant differences between the two samples; specifically, Chinese adolescents’ mean scores on the latent variables of cognitive reappraisal (CR) and expressive suppression (ES) were significantly higher than American adolescents’ scores. The findings demonstrated that the ERQ-CA displays appropriate measurement invariance across Chinese and America adolescents and that Chinese adolescents reported higher scores on CR and ES.
THE FAINT-END SLOPE OF THE REDSHIFT 5.7 Lyα LUMINOSITY FUNCTION,

Using new Keck DEIMOS spectroscopy, we examine the origin of the steep number counts of ultra-faint emission-line galaxies recently reported by Dressler et al. We confirm six Lyα emitters (LAEs), three of which have significant asymmetric line profiles with prominent wings extending 300–400 km s−1 redward of the peak emission. With these six LAEs, we revise our previous estimate of the number of faint LAEs in the Dressler et al. survey. Combining these data with the density of bright LAEs in the Cosmic Evolution Survey and Subaru Deep Field provides the best constraints to date on the redshift 5.7 LAE luminosity function (LF). Schechter function parameters, ϕ* = 4.5 × 10−4 Mpc−3, L* = 9.1 × 1042 erg s−1, and α = −1.70, are estimated using a maximum likelihood technique with a model for slit-losses. To place this result in the context of the UV-selected galaxy population, we investigate how various parameterizations of the Lyα equivalent width distribution, along with the measured UV-continuum LF, affect shape and normalization of the Lyα LF. The nominal model, which uses z ∼ 6 equivalent widths from the literature, falls short of the observed space density of LAEs at the bright end, possibly indicating a need for higher equivalent widths. This parameterization of the equivalent width distribution implies that as many as 50% of our faintest LAEs should have MUV > −18.0, rendering them undetectable in even the deepest Hubble Space Telescope surveys at this redshift. Hence, ultra-deep emission-line surveys find some of the faintest galaxies ever observed at the end of the reionization epoch. Such faint galaxies likely enrich the intergalactic medium with metals and maintain its ionized state in the post-reionization era. Observations of these objects provide a glimpse of the building blocks of present-day galaxies at an early time.
Forecast Constraints on Inflation from Combined CMB and Gravitational Wave Direct Detection Experiments

We study how direct detection of the inflationary gravitational wave background constrains inflationary parameters and complements CMB polarization measurements. The error ellipsoids calculated using the Fisher information matrix approach with Planck and the direct detection experiment, Big Bang Observer (BBO), show different directions of parameter degeneracy, and the degeneracy is broken when they are combined. For a slow-roll parametrization, we show that BBO could significantly improve the constraints on the tensor-to-scalar ratio compared with Planck alone. We also look at a quadratic and a natural inflation model. In both cases, if the temperature of reheating is also treated as a free parameter, then the addition of BBO can significantly improve the error bars. In the case of natural inflation, we find that the addition of BBO could even partially improve the error bars of a cosmic variance-limited CMB experiment.
High braking index pulsar PSR J1640-4631: low-mass neutron star with a large inclination angle?

Recent timing observation constrained the braking index of the X-ray pulsar PSR J1640-4631 to be n = 3.15 ± 0.03, which is the highest value of all pulsars with measured braking indices so far. In this Letter, we investigate whether pulsar braking by combined between the magnetic dipole emission and the gravitational radiation might have a braking index greater than three. For conventional neutron star and low mass quark star candidates, the inferred ellipticities derived by the observed braking index are obviously much larger than the theoretical estimated maximum value. If PSR J1640-4631 is a low-mass neutron star with a mass of 0.1 M ⊙ , the inferred ellipticity can be approximately equal to the theoretical estimated maximum value. Because of the radio-quiet nature of this source, we employ the vacuum gap model developed by Ruderman and Sutherland to constrain the inclination angle to be 87.2 − 90°. Based on this, we propose that a low-mass neutron star with a large inclination angle can interpret the high braking index and the radio-quiet nature of this source. Future observations such as gravitational wave detection and long-term timing for this source are required to confirm or confute our scenario.
Dice Similarity and TF-IDF for New Student Admissions Chatbot

CS is one of the most important functions of any client-related organization, whether a business or a school (customer service). Notably from the committee responsible for student selection, CS, on the other hand, has a very limited capacity to be handled by humans, which can reduce university satisfaction. Therefore, we require technological assistance, which in this case takes the form of an AI-based chatbot. The objective of this study is to design and develop a chatbot system utilizing NLP (natural language processing) to aid the CS of the new student admissions committee at Pahlawan Tuanku Tambusai University in answering questions from prospective new students. The employed method is dice similarity weighted by TFIDF. The results of the conducted tests indicated that the recall rate was 100 percent and the precision reached 76.92 percent. The evaluation results indicate that the chatbot can effectively respond to questions from prospective students.
Demonstration of a quantum error correction for enhanced sensitivity of photonic measurements

The sensitivity of classical and quantum sensing is impaired in a noisy environment. Thus, one of the main challenges facing sensing protocols is to reduce the noise while preserving the signal. State of the art quantum sensing protocols that rely on dynamical decoupling achieve this goal under the restriction of long noise correlation times. We implement a proof-of-principle experiment of a protocol to recover sensitivity by using an error correction for photonic systems that does not have this restriction. The protocol uses a protected entangled qubit to correct a single error. Our results show a recovery of about 87% of the sensitivity, independent of the noise rate.
How Emotional Intelligence Moderate the Relation between Perceived Justice and Counterproductive Behaviours?

This paper aims to reveal the power of emotional intelligence in buffering employees’ negative reactions to perceived organisational injustice manifested in counterproductive work behaviours. To test the proposed relationships, a sample of 345 employees working in hospitality private sector in Cairo-Egypt was approached. Tests of between-subjects Effects and Z-score were used to test the moderating effect of emotional intelligence. The results supported the moderating effect of emotional intelligence for counterproductive work behaviours in general and to counterproductive work behaviours directed to people specifically. As expected, high emotional intelligence people are less involved in to counterproductive work behaviours even with perceived injustice. Interestingly, individuals with moderate level of emotional intelligence were found to be more involved in CWB than people with low EI when they perceive injustice. These results could have several empirical and theoretical implications.
Communication in pediatric oncology

Introduction: Neoplasms are the second most frequent cause of death in the pediatric population. In Poland, approximately 1100-1200 new cases of malignant neoplasms are diagnosed annually. Communication is an extremely important factor in pediatric oncology care. Hence, more and more research on its functions, significance, but also barriers and limitations is being developed. Material, methods, purpose: The literature published in the PubMed scientific database was searched using the following keywords: communication, pediatrics, oncology in 2016-2022. The aim of this review is to show the barriers, functions, and the importance of communication in pediatric oncology for the therapeutic process. Results: Communication in pediatric oncology was shown to perform the following functions: building relationships, exchanging information, enabling the family to self-manage, making decisions, managing uncertainty, responding to emotions, providing validation, and supporting hope. It was also noted that high-quality communication is associated with parental peace, increased recognition and confidence in healthcare professionals. Parents who receive understandable prognostic information have found less regret, as well as a desire to maximize time spent together with their child. Research shows communication barriers on many levels, such as: lack of comfort in difficult topics, time pressure, or the lack of a common mental model of the team and excessive demands. However, knowing these limitations is crucial to improving and overcoming these barriers. Conclusions: Communication in pediatric oncology plays many fundamental roles and constitutes an important aspect of the therapeutic process. Accordingly, it is important to emphasize the development and improvement of healthcare professionals' communication skills. Doctors can use knowledge of communication functions to better understand and fulfill parents' communication needs.