Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of 6 Weeks of Creatine Monohydrate Supplementation on Dynamic Rate of Force Development

The effects of creatine supplementation on force-time curve (FTC) characteristics were investigated in collegiate track athletes. Sixteen male and 20 female athletes were randomly divided into a placebo (P, n = 21) and a creatine (Cr, n = 15) group. Six weeks of supplementation consisted 0.3 g per kilogram of body weight per day of Cr monohydrate or non-nutritive placebo. Subjects were involved in a periodized weight-training program centered on explosive exercises. Pretesting and posttesting consisted of 7-site skinfold analysis, countermovement vertical jump (CMJ), and static vertical jump (SJ). SJ was performed on a 61.0-χ 121.9-cm ATMI (Advanced Medical Technologies, Newton, MA) force plate and was analyzed for FTC. No differences were found between the 2 treatments for FTC. The CMJ showed a significant group by time interaction with the Cr group improving at a greater rate than did the P group. Lean body mass (LBM) significantly increased in the Cr group after the treatment period. These results suggest that 6 weeks of Cr supplementation can favorably enhance LBM and CMJ performance in track athletes.
Pewss: A platform of extensible workflow simulation service for workflow scheduling research

This paper presents a Platform of Extensible Workflow Simulation Service (Pewss), which we have developed to provide a cloud service for aiding research work in workflow scheduling. The simulation has been a major tool for performance evaluation and comparison in workflow scheduling research. However, researchers usually have to develop their own simulation programs with limited functionality, simply outputting summarized performance results. Pewss has been developed for easing and improving current practices in conducting performance simulations during studying of existing workflow scheduling algorithms or designing of new scheduling algorithms. Pewss has been designed based on the Software as a Service (SaaS) model, adopting a multiuser Web‐based client/server architecture. Conducting simulation experiments on Pewss, researchers simply have to implement the scheduling algorithm under study instead of a whole simulation environment, allowing them to focus on their research work without spending unnecessary efforts on the simulation implementation details. Pewss provides the visualization of a workflow execution schedule based on simulation results, offering a convenient way for researchers to gain an insight into the effectiveness, characteristics, and performance bottleneck of scheduling algorithms. As a multiuser environment, Pewss also provides functionality for researchers to facilitate comparative performance analysis and collaborative research works effectively. Pewss has been used in our research work on task‐parallel workflow scheduling and has been planned to be extended to support other types of workflow scheduling research problems, eg, mixed‐parallel workflows.
MMRUC3: A recommendation approach of move method refactoring using coupling, cohesion, and contextual similarity to enhance software design

Placement of methods is one of the most important design activities for any object‐oriented application in terms of coupling and cohesion. Due to method misplacement, the application becomes tightly coupled and loosely cohesive, reflecting inefficient design. Therefore, a feature envy code smell emerges from the application, as many methods use more features of other classes than its current class. Hence, development and maintenance time, cost, and effort are increased. To refactor the code smell and enhance the design quality, move method refactoring plays a significant role through grouping similar behaviors of methods. This is because the manual refactoring process is infeasible due to the necessity of huge time and most of the existing techniques consider only coupling‐based and/or cohesion‐based information of nonstatic entities (methods and attributes) for the recommendation. However, this article proposes an approach that uses contextual information, based on information retrieval techniques, along with dependency (coupling and cohesion)‐based information of the application for the recommendation. In addition, the approach incorporates both static and nonstatic entities in the recommendation process. For validation, the approach is applied on seven well‐known open source projects. The results of the experimental evaluation indicate that the proposed approach provides better results with an average precision of 18.91%, a recall of 69.91%, and an F‐measure of 29.77% than the JDeodorant tool (a widely used eclipse plugin for refactorings). Moreover, this article establishes several relationships between the accuracy of the approach and project standards and sizes.
Changes in serum alanine aminotransferase levels in telbivudine versus lamivudine treatment for chronic hepatitis B: A meta-analysis

Objective A meta-analysis to compare the efficacy and safety of telbivudine (TBV) and lamivudine (LAM) in patients with chronic hepatitis B (CHB), assessed via changes in serum alanine aminotransferase (ALT) levels. Method The electronic literature databases PubMed®, Embase®, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, China BioMedicine and China National Knowledge Infrastructure were searched for relevant studies. The effect of TBV and LAM treatment on serum ALT was assessed using standard mean differences (SMDs) and 95% confidence intervals (CI). Results The meta-analysis included six studies (TBV n = 202; LAM, n = 208). Post-treatment ALT levels were significantly lower than pretreatment values for both TBV and LAM (TBV: SMD = 3.00, 95%CI 1.91, 4.09; LAM: SMD = 2.33, 95%CI 1.58, 3.07). Post-treatment ALT was significantly lower after treatment with TBV than LAM (SMD = 0.58, 95%CI 0.21, 0.94). Conclusion Both LAM and TBV are effective in normalizing ALT levels in patients with CHB, but TBV may be a better choice due to its lower rates of drug resistance.
Effect of blood-sugar limitation on intensive care mortality: Intragroup evaluation

Objective To evaluate the safety profile of blood sugar limits in intensive care unit (ICU) patients. Methods Adult patients with ICU stay >36 h, more than two blood sugar measurements and antibiotic therapy concordant with locally adapted guidelines were included. For analyses, one study cohort was defined in two ways: as a narrow group, euglycaemic patients’ blood sugar levels 80–150 mg/dl; as a moderate group, euglycaemic patients’ blood sugar levels 80–180 mg/dl. Dysglycaemia was defined as blood sugar levels <80 mg/dl for >5% of measurements, and >150 mg/dl or >180 mg/dl (narrow or moderate groups, respectively) for >10% of measurements. The primary endpoint was ICU mortality (euglycaemia versus dysglycaemia). Results The study comprised 668 patients. When defined as a narrow group, ICU mortality was 3% (four of 135) euglycaemic versus 10% (54/533) dysglycaemic patients (odds ratio [OR] 3.692, 95% confidence interval [CI] 1.313, 10.382). When defined as a moderate group, ICU mortality was 6% (21/351) euglycaemic versus 12% (37/317) dysglycaemic patients (OR 2.077, 95% CI 1.188, 3.630). Frequency of severe hypoglycaemia (blood sugar <40 mg/dl) was not different between the narrow and moderate euglycaemic ranges. Conclusions Euglycaemia was associated with lower ICU mortality than dysglycaemia, and incidence of hypoglycaemia was low overall in this study. Based on current published evidence, therapeutic targets should be defined according to individual patient characteristics.
Acute Effects of PM 10 on Asthma Hospitalization Among Children and Benefit Analysis at Four Major Cities in Korea

【This study assessed the relationships between levels of $PM_{10}$ and hospitalization rates for asthma among children from 2003 to 2005 at four major cities in Korea. In addition, we estimated the reduced number of asthma hospitalization associated with an ambient $PM_{10}$ improvement to the acceptable levels as recommended by the World Health Organization (WHO). The Generalized Additive Model (GAM) was used to estimate the relative risks (RR) of asthma hospitalization associated with changes in $PM_{10}$ The RRs of children's asthma hospitalization for every $10{\mu}g/m^3$ increment in $PM_{10}$ were 1.009(95% CI = 1.004-1.014) in Seoul, 1.013(95% CI = 1.006-1.021) in Incheon, 1.009(95% CI = 1.002-1.016) in Busan, and 1.021(95% CI = 1.005-1.037) in Ulsan. We assessed $PM_{10}$ related health benefits from implementing the WHO's guidelines (24-hour average $50{\mu}g/m^3$ ) using the U.S. Environmental Protection Agency's Environmental Benefits Mapping and Analysis Program. The estimated benefits were 439(95% CI = 216-666) reduced asthma hospitalization in Seoul, 720(95% CI = 304-1,151) in Incheon, 260(95% CI = 66-459) in Busan, and 126(95% CI = 30-228) in Ulsan. It was concluded that improving $PM_{10}$ condition to the WHO guideline would make a significant contribution to the reduction in asthma hospitalization among children. Therefore, public health measures are still needed to improve air quality in Korea. 】
Broadband Modulation of Light by Using an Electro-Optic Polymer

A major challenge to increasing bandwidth in optical telecommunications is to encode electronic signals onto a lightwave carrier by modulating the light up to very fast rates. Polymer electro-optic materials have the necessary properties to function in photonic devices beyond the 40-GHz bandwidth currently available. An appropriate choice of polymers is shown to effectively eliminate the factors contributing to an optical modulator's decay in the high-frequency response. The resulting device modulates light with a bandwidth of 150 to 200 GHz and produces detectable modulation signal at 1.6 THz. These rates are faster than anticipated bandwidth requirements for the foreseeable future.
A Study of Material Extraction and Moisture Effect on mmWave Fan-out Package Design

In order to ensure the performance of high-frequency fan-out package design, especially at mmWave application, the influence of substrate dielectric characteristic is very serious. Polyimide (PI) material is common material used in Fan-out package. The moisture effect of PI is very obvious in stress and electrical performance. Sso this paper introduces the method of dielectric constant (Dk) and dissipation factor (Df) extraction. And then the moisture effect on transmission line loss and phase are also studied in this paper, the frequency is up to mmWave range.
Memoryless execution: A programmer's viewpoint

A set of rules for memoryless execution on third‐gene ration computer systems is presented. These rules facilitate binary memoryless interactions within the context of a trustable operating system, without restricting the dynamic use of central processor general purpose registers. An estimate of the required machine support indicates that the firmware modifications required for an implementation based on a segmented microprogrammable computer are not extensive. It is shown that the impact of the solution on operating system design is modest. Moreover, programming generality among memoryless programs is maintained.
On the JEDEC Board Level Drop Test Simulation of Array of BGA Packages

Drop test durability has been a major concern for devices widely used in mobile applications. JEDEC standard is introduced to characterize IC package drop performance such that a consumer product manufacturer could have a readily available benchmark to assess reliability of components from different suppliers under the same test conditions. At first explicit solvers were extensively used to tackle the free fall problem due to its transient and dynamic nature. They were soon simplified to Input-G method to avoid complexity in modeling contact event. Still their inherent poor numerical stability during simulation has limited its application to drop events with small to medium size unless the analysis utilizes very fine time incremental steps, which, in turn, is time consuming. In addition, many component suppliers usually do not have such software. Therefore, implicit solver has recently been employed to simulate board level drop test. Its limitation lies with its connate incompatibility with the direct application of the base acceleration profile but can be overcome by additional treatment of the boundary conditions. This paper investigates the simulation methodologies of JEDEC board level drop test using implicit solver. It demonstrates that both Direct Acceleration Input (DAI) method and Large Mass Method (LMM) could be used to model the current industrial specified drop test, which is a moderate transient process, but the latter is a better option as it captures the real response of the package assembly under test. Actual drop tests were carried out and compared with simulation predictions, they are found in good agreement. Further examination of the current common industrial practice raises concerns about the accuracy of its data collection and interpretation of JEDEC board level drop test results. Possible solutions are offered for improvement of board design and data analysis.
The Genome of the Basidiomycetous Yeast and Human Pathogen Cryptococcus neoformans

Cryptococcus neoformans is a basidiomycetous yeast ubiquitous in the environment, a model for fungal pathogenesis, and an opportunistic human pathogen of global importance. We have sequenced its ∼20-megabase genome, which contains ∼6500 intron-rich gene structures and encodes a transcriptome abundant in alternatively spliced and antisense messages. The genome is rich in transposons, many of which cluster at candidate centromeric regions. The presence of these transposons may drive karyotype instability and phenotypic variation. C. neoformans encodes unique genes that may contribute to its unusual virulence properties, and comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes.
Efficacy of solifenacin in the prevention of short-term complications after laparoscopic radical prostatectomy

Objective To evaluate the efficacy of solifenacin in the prevention of short-term complications after laparoscopic radical prostatectomy (LRP). Methods This randomized placebo-controlled study enrolled patients with histologically proven prostate cancer who underwent LRP. The patients were randomized to receive either solifenacin (5 mg once daily; study group) or placebo (control group) for the 15-day period beginning on the first day after surgery. The mean duration of detrusor overactivity (DO), the frequency of DO, the duration of macroscopic haematuria, and the days before catheter removal were recorded. The International Continence Society Short Form Male questionnaire, bladder neck stenosis episodes, and maximum urinary flow rate were evaluated at 1 month after surgery. The side-effects after using solifenacin were also recorded. Results A total of 120 patients were randomly assigned to the study group (n = 62) or the control group (n = 58). There were significantly lower rates of DO episodes during the daytime and night-time, haematuria and transient incontinence in the study group compared with the control group. Conclusion Solifenacin was a well-tolerated and effective treatment for the prevention of complications after LRP, with the main advantage compared with placebo being the decreased frequency of DO episodes during the daytime and night-time.
RNA Polymerase IV Directs Silencing of Endogenous DNA

Plants encode subunits for a fourth RNA polymerase (Pol IV) in addition to the well-known DNA-dependent RNA polymerases I, II, and III. By mutation of the two largest subunits (NRPD1a and NRPD2), we show that Pol IV silences certain transposons and repetitive DNA in a short interfering RNA pathway involving RNA-dependent RNA polymerase 2 and Dicer-like 3. The existence of this distinct silencing polymerase may explain the paradoxical involvement of an RNA silencing pathway in maintenance of transcriptional silencing.
Samekana: A Browser Extension for Including Relevant Web Links in Issue Tracking System Discussion Forum

Several widely used Issue tracking systems (such as Google Issue Tracker and Bugzilla) contains an integrated threaded discussion forum to facilitate discussion between the development and maintenance team (bug reporters, bug triagers, bug fixers and quality assurance managers). We observe that several comments (and even bug report descriptions) posted to issue tracing system contains links to external websites as references to knowledge sources relevant to the discussion. We conduct a survey (and present the results of the survey) of Google Chromium Developers on the importance and usefulness of web references in issue tracking system comments and the need of a web-browser extension which facilitates easy organization and inclusion of web-links in the post. We conduct a characterization study on an experimental dataset from Google Chromium Issue Tracking system and present results on the distribution of number of links in the dataset, categorization of links into pre-defined classes (such as blogs, community based Q&A websites, developer discussion forums, version control system), correlation of number and types of links with various bug report types (such as security, crash, regression and clean-up) and relation between presence of links and bug resolution time. Survey results and data characterization study motivate the need of building a developer productivity tool to facilitate web-link (as references) organization and inclusion in issue tracking system comments. We present a Google Chromium Web Browser Extension called as Samekana and publish the extension on Google Chromium Web Store which can be freely downloaded by users worldwide. The extension contains features such as annotating (using tags, title and description) and saving web references pertaining to multiple bug reports and tasks and then posting it as bibliography (for easy citation and reference) in issue tracking system comments.
Automatic trimap generation for digital image matting

Digital image matting is one of the most popular topics in image processing in recent years. For most matting methods, trimap serves as one of the key inputs, and the accuracy of the trimap affects image matting result a lot. Most existing works did not pay much attention to acquiring a trimap; instead, they assumed that the trimap was given, meaning the matting process usually involved users' inputs. In this paper, an automatic trimap generation technique is proposed. First, the contour of the segmentation result is dilated to get an initial guess of the trimap followed by alpha estimation. Then, a smart brush with dynamic width is performed by analyzing the structure of the foreground object to generate another trimap. In other words, the brush size is enlarged if the object boundary contains fine details like hair, fur, etc. On the contrary, the brush size gets smaller if the contour of the object is just a simple curve or straight line. Moreover, by combining the trimap obtained in step one and downsampling the image, the uncertainty is defined as the blurred region, and the third trimap is formed. The final step is to combine these three trimaps together by voting. The experimental results show that the trimap generated by the proposed method effectively improves the matting result. Moreover, the enhancement of the accuracy of the trimap results in a reduction of regions to be processed, so that the matting procedure is accelerated.
A Fortran to Pascal translator

This paper describes some of the problems encountered in implementing an automatic Fortran to Pascal translator. The translator introduces a number of improvements to the Fortran program including the structured control statements of Pascal. It highlights the structure of both COMMON blocks and executable statements, and it nests the Fortran subprograms to their required level.
Regulation of Sexual Development of Plasmodium by Translational Repression

Translational repression of messenger RNAs (mRNAs) plays an important role in sexual differentiation and gametogenesis in multicellular eukaryotes. Translational repression and mRNA turnover were shown to influence stage-specific gene expression in the protozoan Plasmodium. The DDX6-class RNA helicase, DOZI (development of zygote inhibited), is found in a complex with mRNA species in cytoplasmic bodies of female, blood-stage gametocytes. These translationally repressed complexes are normally stored for translation after fertilization. Genetic disruption of pbdozi inhibits the formation of the ribonucleoprotein complexes, and instead, at least 370 transcripts are diverted to a degradation pathway.
Integrated Strategy for Unknown EI-MS Identification Using Quality Control Calibration Curve, Multivariate Analysis, EI-MS Spectral Database, and Retention Index Prediction.

Compound identification using unknown electron ionization (EI) mass spectra in gas chromatography coupled with mass spectrometry (GC-MS) is challenging in untargeted metabolomics, natural product chemistry, or exposome research. While the total count of EI-MS records included in publicly or commercially available databases is over 900 000, efficient use of this huge database has not been achieved in metabolomics. Therefore, we proposed a "four-step" strategy for the identification of biologically significant metabolites using an integrated cheminformatics approach: (i) quality control calibration curve to reduce background noise, (ii) variable selection by hypothesis testing in principal component analysis for the efficient selection of target peaks, (iii) searching the EI-MS spectral database, and (iv) retention index (RI) filtering in combination with RI predictions. In this study, the new MS-FINDER spectral search engine was developed and utilized for searching EI-MS databases using mass spectral similarity with the evaluation of false discovery rate. Moreover, in silico derivatization software, MetaboloDerivatizer, was developed to calculate the chemical properties of derivative compounds, and all retention indexes in EI-MS databases were predicted using a simple mathematical model. The strategy was showcased in the identification of three novel metabolites (butane-1,2,3-triol, 3-deoxyglucosone, and palatinitol) in Chinese medicine Senkyu for quality assessment, as validated using authentic standard compounds. All tools and curated public EI-MS databases are freely available in the 'Computational MS-based metabolomics' section of the RIKEN PRIMe Web site ( http://prime.psc.riken.jp ).
Vehicle Energy-Saving Motion Planning Based on Deep Q-Network

Energy-saving driving of vehicles has become the general trend. This paper will take driverless vehicle as the research object, and use the algorithm of deep reinforcement learning to carry out energy-saving motion planning. First, a virtual driving simulation scene of driverless vehicle that can be applied with deep reinforcement learning is built. Secondly, the vehicle longitudinal DQN algorithm is designed. Aiming at the energy-saving driving behavior in the vehicle-following scenario, the proposed DQN controller is verified when the speed of preceding vehicle is fixed and variable. Last but not least, the problem of energy-saving passing through traffic light intersections is explored, mainly on two typical conditions in passing traffic lights: quickly pass and glide through. The vehicle based on DQN algorithm can pass the above two traffic light intersections without stopping midway and violating traffic rules. In the above experiments, compared with the comparison experiment, the average instantaneous energy consumption of the ego vehicle based on the DQN algorithm is reduced.