Miracle-dz/UniFAR-FTUs huggingface dataset:
Zebrafish Paralogs brd2a and brd2b Are Needed for Proper Circulatory, Excretory and Central Nervous System Formation and Act as Genetic Antagonists during Development

Brd2 belongs to the BET family of epigenetic transcriptional co-regulators that act as adaptor-scaffolds for the assembly of chromatin-modifying complexes and other factors at target gene promoters. Brd2 is a protooncogene and candidate gene for juvenile myoclonic epilepsy in humans, a homeobox gene regulator in Drosophila, and a maternal-zygotic factor and cell death modulator that is necessary for normal development of the vertebrate central nervous system (CNS). As two copies of Brd2 exist in zebrafish, we use antisense morpholino knockdown to probe the role of paralog Brd2b, as a comparative study to Brd2a, the ortholog of human Brd2. A deficiency in either paralog results in excess cell death and dysmorphology of the CNS, whereas only Brd2b deficiency leads to loss of circulation and occlusion of the pronephric duct. Co-knockdown of both paralogs suppresses single morphant defects, while co-injection of morpholinos with paralogous RNA enhances them, suggesting novel genetic interaction with functional antagonism. Brd2 diversification includes paralog-specific RNA variants, a distinct localization of maternal factors, and shared and unique spatiotemporal expression, providing unique insight into the evolution and potential functions of this gene.
Real time high precision simulation of the HVDC extinction advance angle

Fields of interest for the use of real time digital simulators for electromagnetic transients include the testing of power system devices such as controllers and protective relays in high voltage direct current (HVDC) systems. The accuracy of real time HVDC simulations is strongly influenced by the way the switching processes and the quantities which constitute the inputs to the controllers are dealt with by the simulation algorithms. In this paper a simulation algorithm for the real time simulation of the extinction advance angle, which is processed by the HVDC controller, is presented. A case study involving the well-known CIGRE HVDC benchmark system is used to demonstrate the resulting quality improvement which is achieved.
Selective Dual Duty Cycle Controlled High Frequency Inverter Using a Resonant Capacitor in Parallel with an Auxiliary Reverse Blocking Switch

This paper presents a new ZCS-PWM high frequency inverter. Zero current switching operation is achieved in the whole load range by using a simple auxiliary reverse blocking switch in parallel with series resonant capacitor. Dual duty cycle control scheme is used to provide a wide range of high frequency AC output power regulation that is important in many high frequency inverter applications. It found that a complete soft switching operation can be achieved even for low power setting ranges by introducing high-frequency dual duty cycle control scheme. The proposed high frequency inverter is more suitable for consumer induction heating (IH) applications. The operation and control principle of the proposed high frequency inverter are described and verified through simulated results.
Brief communication: Lower-bound estimates for residence time of energy in the atmospheres of Venus, Mars and Titan

Abstract. The residence time of energy in a planetary atmosphere, τ, which was recently introduced and computed for the Earth's atmosphere (Osácar et al., 2020), is here extended to the atmospheres of Venus, Mars and Titan. τ is the timescale for the energy transport across the atmosphere. In the cases of Venus, Mars and Titan, these computations are lower bounds due to a lack of some energy data. If the analogy between τ and the solar Kelvin–Helmholtz scale is assumed, then τ would also be the time the atmosphere needs to return to equilibrium after a global thermal perturbation.
Secure Adaptive Trajectory Tracking Control for Nonlinear Robot Systems Under Multiple Dynamic Obstacles: Safety Barrier Certificates

This article studies the problem of obstacle-avoidance tracking control for a class of uncertain nonlinear robot systems in multiple-dynamic-obstacles environment. The main challenge focuses on how to simultaneously ensure tracking performance and obstacle avoidance. The existing collision-avoidance tracking control schemes cannot guarantee the tracking performance inside the obstacle detection region, since the use of additive Lyapunov-barrier function (LBF) generates the dynamic mismatching. To overcome this difficulty, a novel integral-multiplicative LBF is constructed. The adaptive mechanism is designed to compensate for the mismatching uncertainties. By incorporating the barrier function into backstepping procedure, a secure adaptive tracking control scheme is proposed. Compared with the existing results, the proposed control scheme can simultaneously achieve the obstacle avoidance and tracking performance regardless of being inside the obstacle sensing region and unknown nonlinear uncertainties.
It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis

Background There is concern that blood pressure (BP) lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis. We assessed the effect of glyceryl trinitrate (GTN) in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke (ENOS) Trial. Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP (140–220 mm Hg) to transdermal GTN or no GTN within 48 hours of onset. Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days. The primary outcome was the modified Rankin Scale (mRS) at day 90. Ipsilateral carotid stenosis was split: <30%; 30–<50%; 50–<70%; ≥70%. Data are ORs with 95% CIs adjusted for baseline prognostic factors. Results 2023 (60.5%) ischaemic stroke participants had carotid imaging. As compared with <30%, ≥70% ipsilateral stenosis was associated with an unfavourable shift in mRS (worse outcome) at 90 days (OR 1.88, 95% CI 1.44 to 2.44, p<0.001). Those with ≥70% stenosis who received GTN versus no GTN had a favourable shift in mRS (OR 0.56, 95% CI 0.34 to 0.93, p=0.024). In those with 50–<70% stenosis, continuing versus stopping prestroke antihypertensives was associated with worse disability, mood, quality of life and cognition at 90 days. Clinical outcomes did not differ across bilateral stenosis groups. Conclusions Following ischaemic stroke, severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days. GTN appears safe in ipsilateral or bilateral carotid stenosis, and might improve outcome in severe ipsilateral carotid stenosis.
The Cut of Women’s Clothes

Each period in the history of costume has produced its own characteristic line and silhouette, derived from a cut and construction which varies considerably from age to age. Here are patterns taken from actual dresses, many of them rare museum specimens, illustrated by sketches of the dresses. There are notes on the production of women's dress, with references to early technical books and journals, together with diagrams from some of them. Numerous illustrations show the dresses as worn complete with their hairstyles, jewelry, decorations and accessories.
Psychometric Analyses of the Challenges and Needs Survey for Family Caregivers of Individuals with Autism Spectrum Disorder: Implications for Practice

Understanding the needs and stressors of caregivers of individuals with autism spectrum disorder (ASD) informs targeted support strategies. However, most caregiver needs measures lack the breadth of experiences relevant to these families. This study examined the underlying factor structure of the Challenges and Needs Survey (CANS), a caregiving needs measure designed for family caregivers of individuals with ASD. The sample consisted of 286 family caregivers. Participants completed the CANS either online or in the paper form. Exploratory factor analysis was used to examine the underlying structure of the measure. T-tests and correlations were used to compare results by age and gender of the participants. Exploratory factor analysis resulted in 39 items of four factors: autism-related challenges (child), functional challenges, psychological challenges (parent), and aggressive behaviors (child). Parents with both high stress and high needs reported the lowest levels of mental health functioning.
Olaparib Is a Mitochondrial Complex I Inhibitor That Kills Temozolomide-Resistant Human Glioblastoma Cells

Glioblastoma represents the highest grade of brain tumors. Despite maximal resection surgery associated with radiotherapy and concomitant followed by adjuvant chemotherapy with temozolomide (TMZ), patients have a very poor prognosis due to the rapid recurrence and the acquisition of resistance to TMZ. Here, initially considering that TMZ is a prodrug whose activation is pH-dependent, we explored the contribution of glioblastoma cell metabolism to TMZ resistance. Using isogenic TMZ-sensitive and TMZ-resistant human glioblastoma cells, we report that the expression of O6-methylguanine DNA methyltransferase (MGMT), which is known to repair TMZ-induced DNA methylation, does not primarily account for TMZ resistance. Rather, fitter mitochondria in TMZ-resistant glioblastoma cells are a direct cause of chemoresistance that can be targeted by inhibiting oxidative phosphorylation and/or autophagy/mitophagy. Unexpectedly, we found that PARP inhibitor olaparib, but not talazoparib, is also a mitochondrial Complex I inhibitor. Hence, we propose that the anticancer activities of olaparib in glioblastoma and other cancer types combine DNA repair inhibition and impairment of cancer cell respiration.
Somebody’s Watching Me: Smartphone Use Tracking and Reactivity

Like all media use, smartphone use is mostly being measured retrospectively with self-reports. This leads to misjudgments due to subjective aggregations and interpretations that are necessary for providing answers. Tracking is regarded as the most advanced, unbiased, and precise method for observing smartphone use and therefore employed as an alternative. However, it remains unclear whether people possibly alter their behavior because they know that they are being observed. This is called reactivity. In this study, we investigate first, whether smartphone and app use duration and frequency are affected by tracking; second, whether effects vary between app types; and third, how long effects persist.We developed an Android tracking app and conducted an anonymous quasi-experiment with smartphone use data from 25 people over a time span of two weeks. The app gathered not only data that were produced after, but also prior to its installation by accessing an internal log file on the device.The results show that there is a decline in the average duration of app use sessions within the first seven days of tracking. Instant messaging and social media app use duration show similar patterns. We found no changes in the average frequency of smartphone and app use sessions per day. Overall, reactivity effects due to smartphone use tracking are rather weak, which speaks for the method's validity. We advise future researchers to employ a larger sample and control for external influencing factors so reactivity effects can be better interpreted.
Improvement strategies for the tools and techniques of quality improvement: Utilization of a performance evaluation matrix in the taiwanese high‐tech industry

This study integrates importance–performance analysis (IPA) and Slack's IPA matrix to provide a more comprehensive performance‐evaluation matrix for prioritizing improvement actions with regard to the tools and techniques of quality improvement. The study undertakes a review of the literature to identify the tools and techniques most widely used by high‐tech businesses in Taiwan. Following a survey of 394 managers and technicians, these tools and techniques are then placed on the integrated performance‐evaluation matrix to determine appropriate priorities for improvement actions. The study finds that “new seven” total quality management tools are used less often than “old seven” total quality management tools, and that education, training, and the efficient use of corporate resources are required to improve the frequency of utilization and the performance of the tools and techniques of quality improvement. © 2011Wiley Periodicals, Inc.
Effective On-Chip Communication for Message Passing Programs on Multi-Core Processors

Shared memory is the most popular parallel programming model for multi-core processors, while message passing is generally used for large distributed machines. However, as the number of cores on a chip increases, the relative merits of shared memory versus message passing change, and we argue that message passing becomes a viable, high performing, and parallel programming model. To demonstrate this hypothesis, we compare a shared memory architecture with a new message passing architecture on a suite of applications tuned for each system independently. Perhaps surprisingly, the fundamental behaviors of the applications studied in this work, when optimized for both models, are very similar to each other, and both could execute efficiently on multicore architectures despite many implementations being different from each other. Furthermore, if hardware is tuned to support message passing by supporting bulk message transfer and the elimination of unnecessary coherence overheads, and if effective support is available for global operations, then some applications would perform much better on a message passing architecture. Leveraging our insights, we design a message passing architecture that supports both memory-to-memory and cache-to-cache messaging in hardware. With the new architecture, message passing is able to outperform its shared memory counterparts on many of the applications due to the unique advantages of the message passing hardware as compared to cache coherence. In the best case, message passing achieves up to a 34% increase in speed over its shared memory counterpart, and it achieves an average 10% increase in speed. In the worst case, message passing is slowed down in two applications—CG (conjugate gradient) and FT (Fourier transform)—because it could not perform well on the unique data sharing patterns as its counterpart of shared memory. Overall, our analysis demonstrates the importance of considering message passing as a high performing and hardware-supported programming model on future multicore architectures.
Recognition of Human Emotion using Radial Basis Function Neural Networks with Inverse Fisher Transformed Physiological Signals

Emotion is a complex state of human mind influenced by body physiological changes and interdependent external events thus making an automatic recognition of emotional state a challenging task. A number of recognition methods have been applied in recent years to recognize human emotion. The motivation for this study is therefore to discover a combination of emotion features and recognition method that will produce the best result in building an efficient emotion recognizer in an affective system. We introduced a shifted tanh normalization scheme to realize the inverse Fisher transformation applied to the DEAP physiological dataset and consequently performed series of experiments using the Radial Basis Function Artificial Neural Networks (RBFANN). In our experiments, we have compared the performances of digital image based feature extraction techniques such as the Histogram of Oriented Gradient (HOG), Local Binary Pattern (LBP) and the Histogram of Images (HIM). These feature extraction techniques were utilized to extract discriminatory features from the multimodal DEAP dataset of physiological signals. Experimental results obtained indicate that the best recognition accuracy was achieved with the EEG modality data using the HIM features extraction technique and classification done along the dominance emotion dimension. The result is very remarkable when compared with existing results in the literature including deep learning studies that have utilized the DEAP corpus and also applicable to diverse fields of engineering studies.
Pulsed supplies of small fish facilitate short-term intraguild predation in salmon stocked streams

Pulsed supplies of prey organisms generally increase predator food intake. However, whether this holds true when predators and pulsed prey are in same guild (i.e., intraguild [IG] predators and prey) is unclear. IG prey may increase IG-predator food intake by providing a food source, but they may decrease food intake through competition. To test these hypotheses, we compared the food intake of white-spotted charr (Salvelinus leucomaenis) (IG predator) in streams that were stocked or unstocked with hatchery-reared masu salmon (Oncorhynchus masou) fry (IG prey) in streams in Hokkaido, Japan. One day after stocking, masu salmon fry occupied nearly 60% of the stomach contents by wet weight of white-spotted charr in stocked streams, and mean stomach content weight was six-times higher than in unstocked streams. However, predation of white-spotted charr on stocked fry was rare on other days. Acquisition of predator-avoidance behavior by stocked fry and/or a lack of accommodation by white-spotted charr to the sudden emergence of a new prey source (e.g., the charr in study sites were basically insectivorous, and their foraging behavior might have been ineffective for piscivory) may explain this time-limited intraguild predation. In days other than the first day post-stocking, food intake by white-spotted charr did not differ between stocked and unstocked streams. No effects of interspecific competition on white-spotted charr food intake were observed; this may be due to the body-size advantage of white-spotted charr and/or the low density of stocked masu-salmon fry.
Molecular Characterization and Expression of the LAP3 Gene and Its Association with Growth Traits in the Blood Clam Tegillarca granosa

Leucine aminopeptidase 3 (LAP3) is a metallopeptidase that cleaves N-terminal residues and is involved in protein maturation and degradation. In this study, we characterized the leucine aminopeptidase 3 (LAP3) gene from Tegillarca granosa (Tg-LAP3 for short), which appeared to consist of 15,731 nucleotides encoding 530 amino acids. We identified 12 introns and 13 exons in the Tg-LAP3 gene, suggesting a highly conserved genomic structure. The proximal promoter sequence consists of 1922 bps with a typical TATA box structure, which is the general structural characteristic of core promoters in eukaryotes. We found two functional domains in the Tg-LAP3 protein, including an N-terminal domain (41–174aa) and a peptidase_M17 catalytic domain (209–522aa). Multiple alignment showed that Tg-LAP3 shares 73.4% identity with LAP3 of Mizuhopecten yessoensis and 55.2–70.7% identity with LAP3 of other species. Quantitative analysis of Tg-LAP3 in embryos/larvae and adult tissues indicated that the highest expression occurred in eyebot larva, with limited expression in other stages; among tissues, the highest expression was found in the liver (p < 0.05). Association analysis found that three single-nucleotide polymorphisms (SNPs) (g.-488A > G, g.-1123C > T, and g.-1304C > A) in the proximal promoter were successfully typed, but there was no significant difference in growth traits (body weight, shell length, shell width, and shell height) among these genotypes. The results of our study demonstrate the functional roles of the Tg-LAP3 gene and provide valuable information for molecular marker-assisted selection (MAS) of the blood clam.
Molecular dynamics investigation on tilt grain boundary energies of beta-titanium and tungsten at high temperature

The grain boundary energies (GBEs) of symmetric tilt grain boundaries (STGBs) and asymmetric tilt grain boundaries (ATGBs) for W at 0 and 2400 K and β-Ti at 1300 K were calculated by means of molecular statics and dynamics simulations to investigate the effects of temperature on GBE and the relationships between GBEs and grain boundary (GB) planes. Generally, the variation trends of GBE with the tilt angle are similar for the three cases, when the tilt axis is specified. It is of course that these similarities result from their similar GB microstructures in most cases. However, the variation trends of GBE with tilt angle are somewhat different between β-Ti at 1300 K and W at 2400 K for STGBs with <100> and <110> tilt axes. This difference mainly stems from the following two reasons: firstly, the GB microstructures of W at 2400 K and β-Ti at 1300 K are different for some STGBs; secondly, the atoms at the STGB of β-Ti at 1300 K tend to evolve into the local ω- or α-like structures distributed at the STGB for some STGBs with <110> tilt axis, which makes the corresponding STGBs more stable, thereby decreasing the GBEs. Furthermore, a geometric parameter θ, the angle between the misorientation axis and the GB plane, was defined to explore the relationships between GBEs and GB planes. It was found that the relationships between GBEs and GB planes can be described by some simple functions of sin(θ) for the GBs with definite lattice misorientation, which can well explain and predict the preferred GB planes for the GBs having the same lattice misorientation. Our calculations not only extend the investigation of GBs to higher temperature, but also deepen the understanding on the temperature contributions to the microstructure evolution at GBs and on the relationships between GBEs and possible geometric parameters.
Dynamic Modeling of a PWM plus Phase-Shift (PPS) Controlled Active Clamping Boost to Full Bridge Bi-directional DC/DC Converter

PWM plus phase-shift (PPS) control technique is a technique combining PWM control technique and phase-shift control technique. PPS control bidirectional DC-DC converters have two regulating parameters, that is duty cycle D and phase-shift angles Φ. The paper proposed a new technique based on state-space averaging technique for modeling PWM plus phase-shift (PPS) controlled active clamping boost to full bridge bi-directional dc-dc converters, and derives the dynamic model of an active clamping boost to full bridge bi-directional dc-dc converter. The modeling technique is verified by both simulation and experiment.
Gas Chromatographic Fingerprint Analysis for the Comparison of Seized Cannabis Samples

Cannabis sativa L. is widely used as recreational illegal drugs. Illicit Cannabis profiling, comparing seized samples, is challenging due to natural Cannabis heterogeneity. The aim of this study was to use GC–FID and GC–MS herbal fingerprints for intra (within)- and inter (between)-location variability evaluation. This study focused on finding an acceptable threshold to link seized samples. Through Pearson correlation-coefficient calculations between intra-location samples, ‘linked’ thresholds were derived using 95% and 99% confidence limits. False negative (FN) and false positive (FP) error rate calculations, aiming at obtaining the lowest possible FP value, were performed for different data pre-treatments. Fingerprint-alignment parameters were optimized using Automated Correlation-Optimized Warping (ACOW) or Design of Experiments (DoE), which presented similar results. Hence, ACOW data, as reference, showed 54% and 65% FP values (95 and 99% confidence, respectively). An additional fourth root normalization pre-treatment provided the best results for both the GC–FID and GC–MS datasets. For GC–FID, which showed the best improved FP error rate, 54 and 65% FP for the reference data decreased to 24 and 32%, respectively, after fourth root transformation. Cross-validation showed FP values similar as the entire calibration set, indicating the representativeness of the thresholds. A noteworthy improvement in discrimination between seized Cannabis samples could be concluded.