Miracle-dz/UniFAR-FTUs huggingface dataset:
A Didactical Approach for Musculoskeletal Physiotherapy: The Planetary Model

Objective Musculoskeletal physiotherapy has become a well-recognized and respected sub-discipline within the physiotherapy profession. The emergence of the biopsychosocial theory and the implementation of new insights into the pain mechanisms have been two of the most powerful catalysts for change at work within this profession. The fast evolution during past decades gave rise to the need for a structured framework. The purpose of this article is to introduce a didactical model which focuses on the relevant key elements within musculoskeletal physiotherapy. Findings A didactical model is put forward in the form of a “planetary model. ” The planetary model is not a new model, but is a didactic representation mainly inspired by an adapted model of the International Classification of Functioning, Disability and Health [ICF]. The structure of the ICF is reflected in a vertical plan, whereas the pain mechanisms and psychosocial factors surround this vertical structure, reflecting their continuous interaction with the different components of the vertical axis. Conclusions The planetary model enables the therapist to systematically analyze and appraise the impact of the different components as a basis for clinical decisions and aims to contribute to a more efficient way of managing patients.
Informal Human Milk Sharing

Background: Little is known about women’s participation or likely participation in informal human milk (HM) sharing. The US Food and Drug Administration recommends against feeding infants shared HM acquired directly from individuals or through the Internet. Objective: This study explored the experiences of and attitudes toward HM sharing among mothers with experience of HM feeding and breast pump use, regardless of whether or not they had participated in HM sharing. Methods: We conducted qualitative, semistructured, in-depth interviews with 41 mothers from 4 counties in upstate New York, asking about their attitudes toward HM sharing. Interviews were transcribed and analyzed inductively. Results: Most women were aware of informal HM sharing and some had personal experience with sharing. Many mothers reported a willingness to provide their own HM if they had extra and their own child had enough. Mothers were less trusting about receiving HM, voicing concerns about the dietary intake or disease status of potential providers. Mothers felt that whether or not they participated in HM sharing would depend on the situation; they were most amenable to sharing with a family member or close friend. A novel finding was the involvement of lactation consultants and midwives, who coordinated HM exchanges for mothers in this sample. Conclusion: Awareness of HM sharing was high in this sample. Depending on the situation, mothers may consider participating in informal HM sharing and they may be facilitated by health professionals. Future research is required to establish the benefits and risks associated with informal HM sharing.
Detecting anomalous electrical appliance behavior based on motif transition likelihood matrices

With the rise of the Internet of Things, innumerable sensors and actuators are expected to find their way into homes, office spaces, and beyond. Electric power metering equipment, mostly present in the form of smart meters and smart plugs, can thus be anticipated to be installed widely. While smart plugs (i.e., individual power monitors attachable to wall outlets) primarily cater to the user comfort by enabling legacy devices to be controlled remotely, their power measurement capability also serves as an enabler for novel context-based services. We realize one such functionality in this paper, namely the recognition of unexpected behavior and appliance faults based on observed power consumption sequences. To this end, we present a system that extracts characteristic power consumption transitions and their temporal dependencies from previously collected measurements. When queried with a power data sequence collected from the appliance under consideration, it returns the likelihood that the collected power data indicate normal behavior of this appliance. We evaluate our system using real-world appliance-level consumption data. Our results confirm the individual nature of consumption patterns and show that the system can reliably detect errors introduced in the data within close temporal proximity to their time of occurrence.
Comparison of N-terminal Pro-B type Natriuretic Peptide and Tissue Doppler in Diagnosing Diastolic Heart Failure

Background: Heart failure (HF) has become a main cardiac problem. Doppler echocardiography has been used to examine left ventricular (LV) diastolic filling dynamics. Limitations of this modality suggest the need for other objective measures of diastolic HF. Aim of the Study: The hypothesis of this study is to assess the utility of N-terminal pro-B type natriuretic peptide (NTproBNP) in the diagnostic evaluation of diastolic HF in comparison with tissue Doppler imaging (TDI) recordings. Methods: A prospective study was carried out between May 2010 and December 2011. Patients with signs and symptoms of HF with normal LV systolic function by 2D-echocardiography were recruited. M-mode and 2-dimensional images, left atrial volume index (LAVI), spectral and TDI of the mitral annulus were obtained for all the patients. NTproBNP levels were measured with a
The impact of integrated omics technologies for patients with rare diseases

Introduction: New omics technologies enabling the efficient, low-cost and large-scale generation and analysis of biomedical data have revolutionised research in rare diseases, offering new methods to identify novel disease and modifier genes, elucidate disease mechanisms, discover biomarkers, and ultimately identify novel therapeutic targets. Areas covered: An overview is provided of the omics fields of relevance for rare disease: genomics, transcriptomics, proteomics, metabolomics and pharmacogenomics. This is followed by a discussion of the challenges that remain in maximising the potential of these technologies and translating them to clinical benefit, particularly the requirement for large-scale collaboration and data sharing. Expert opinion: The rapid uptake of omics approaches has resulted in major advances in rare disease research and led to an exponential growth in data generation. Data analysis and interpretation is now the major rate-limiting step, and the development of integrated approaches in which data from high-throughput omics technologies can be analysed together and linked to clinical phenotypes and information from registries and biobanks is key. Although this is the best opportunity for rapid progress in stratified and personalised medicine, it requires a change in the traditional mindset of the scientific and clinical community towards greater openness to data sharing.
Multivariable Lagrange Inversion, Gessel-Viennot Cancellation, and the Matrix Tree Theorem

Abstract A new form of multivariable Lagrange inversion is given, with determinants occurring on both sides of the equality. These determinants are principal minors, for complementary subsets of row and column indices, of two determinants that arise singly in the best known forms of multivariable Lagrange inversion. A combinatorial proof is given by considering functional digraphs, in which one of the principal minors is interpreted as a Matrix Tree determinant, and the other by a form of Gessel-Viennot cancellation.
Circular Numbers and n-set Partitions

Partitions ofn-sets and their associated Bell and Stirling numbers are well-studied combinatorial entities. Less studied is the connection between these entities and the moments of a Poisson random variable. We find a natural generalization of this connection by considering the moments of the circular random variables of ordernwhich are sums ofnindependent identically distributed Poisson random variables weighted equally about the unit circle. These are shown to have relationships to partitions of an-set whose blocks are of size divisible bym. From this a rich selection of combinatorial properties analogous to those of the striling numbers are explored. This includes Dobinski-type formulas, recurrence relations, and congruential properties. Some surprises are found in that form? 3 the circular numbers are not unimodal and have no non-trivial recurrences in (n, k) of fixed ordernwith coefficients depending onk, yet they have many analogous congruential properties.
Depression, Disability and Intermediate Pathways: A Review of Longitudinal Studies in Elders

Cross-sectional studies demonstrate depression is associated with disability in elders. These studies also report that disability in depressed elders is associated with greater medical illness burden, cognitive impairment, and behavioral changes. Only longitudinal studies, however, can determine the impact of depression and its comorbidities on functional decline. This review summarizes the findings of 20 longitudinal studies examining the relationship between baseline or incident depression and functional decline. However, the mediational effects of potential risk factors identified by cross-sectional studies cannot be derived from the current literature. We propose a mediational effects model for future longitudinal studies, incorporating measures sensitive to both mood symptoms and the medical, cognitive, and behavioral comorbidities of depression to better understand the impact of each on functional decline and to focus future clinical interventions.
The Reasons for Nursing Home Entry in an Adult Day Care Population: Caregiver Reports Versus Regression Results

This article aims to compare reasons for nursing home entry determined through a regression of baseline predictors to relatives’ perceptions of reasons for entry. Participants included 201 community-residing members of 5 senior day care centers in Maryland. Through a prospective design, statistical predictors using Cox regressions were compared to the relatives’ reports of reasons for nursing home entry. These reports identified the most common reasons for nursing home entry as deterioration of independence and confusion. Behavior problems were also reported for almost half of the participants. In contrast, strong baseline statistical predictors of institutionalization were depressed affect, number of psychiatric diagnoses, a diagnosis of dementia, and age. Because of its strong significance within the baseline predictors, the meaning of depressed affect and why it was such a potent predictor of nursing home entry, yet still not reported by caregivers, should be studied further.
Decreased C-Reactive Protein Levels in Alzheimer Disease

C-reactive protein (CRP) is an acute-phase reactant that has been found to be associated with Alzheimer disease (AD) in histopathological and longitudinal studies; however, little data exist regarding serum CRP levels in patients with established AD. The current study evaluated CRP levels in 192 patients diagnosed with probable AD (mean age = 75.8 ± 8.2 years; 50% female) as compared to 174 nondemented controls (mean age = 70.6 ± 8.2 years; 63% female). Mean CRP levels were found to be significantly decreased in AD (2.9 µg/mL) versus controls (4.9 µg/mL; P = .003). In adjusted models, elevated CRP significantly predicted poorer (elevated) Clinical Dementia Rating Scale sum of boxes (CDR SB) scores in patients with AD. In controls, CRP was negatively associated with Mini-Mental State Examination (MMSE) scores and positively associated with CDR SB scores. These findings, together with previously published results, are consistent with the hypothesis that midlife elevations in CRP are associated with increased risk of AD development though elevated CRP levels are not useful for prediction in the immediate prodrome years before AD becomes clinically manifest. However, for a subgroup of patients with AD, elevated CRP continues to predict increased dementia severity suggestive of a possible proinflammatory endophenotype in AD.
Erprobung von Methoden zur Sammlung und Konservierung von Urinproben für die Labordiagnostik bei Urolithiasis. Assay of Urine Collection and Preservation Methods in the Diagnosis of Urolithiasis

Zur Überprüfung des Einflusses von Konservierung und Lagerung auf die Meßergebnisse der Zitronensäure-, Calcium-, Oxalsäureund Harnsäurebestimmung wurden 20 frisch gesammelte Urine in je vier Portionen unterteilt. Eine Portion blieb ohne Konservierung, der zweiten wurde 2% ige Borsäure zugesetzt, der dritten 25%ige HCI und der vierten 5%iges Thymol in Isopropanol. Thymol erwies sich als geeignetes Konservierungsmittel zur Vorlage in die Sammelgefäße, da die Substanz eine bakterielle Kontamination und den damit verbundenen Citratverlust wirksam verhindert und zudem den pH-Wert des Urins nicht beeinflußt. Kann ein Urin nicht sofort nach dem Sammeln analysiert werden, müssen zur Stabilisierung der Calciumund Oxalsäurewerte entsprechende Proben für diese Bestimmungen vor der Lagerung angesäuert werden (pH-Wert < 1.5), für die Harnsäurebestimmung müssen die Proben alkalisiert werden. Hierdurch gehen auch nach dem Auftauen alle gebildeten Kristalle wieder leicht in Lösung.
Neuroimaging Findings in Late-Onset Schizophrenia and Bipolar Disorder

In recent years, there has been an increasing interest in late-onset mental disorders. Among them, geriatric schizophrenia and bipolar disorder are significant health care risks and major causes of disability. We discussed whether late-onset schizophrenia (LOS) and late-onset bipolar (LOB) disorder can be a separate entity from early-onset schizophrenia (EOS) and early-onset bipolar (EOB) disorder in a subset of late-life schizophrenia or late-life bipolar disorder through neuroimaging studies. A literature search for imaging studies of LOS or LOB was performed in the PubMed database. Search terms used were “(imaging OR MRI OR CT OR SPECT OR DTI OR PET OR fMRI) AND (schizophrenia or bipolar disorder) AND late onset. ” Articles that were published in English before October 2013 were included. There were a few neuroimaging studies assessing whether LOS and LOB had different disease-specific neural substrates compared with EOS and EOB. These researches mainly observed volumetric differences in specific brain regions, white matter hyperintensities, diffusion tensor imaging, or functional neuroimaging to explore the differences between LOS and LOB and EOS and EOB. The aim of this review was to highlight the neural substrates involved in LOS and LOB through neuroimaging studies. The exploration of neuroanatomical markers may be the key to the understanding of underlying neurobiology in LOS and LOB.
Quickly Excluding a Planar Graph

Abstract In an earlier paper, the first two authors proved that for any planar graph H , every graph with no minor isomorphic to H has bounded tree width; but the bound given there was enormous. Here we prove a much better bound. We also improve the best known bound on the tree-width of planar graphs with no minor isomorphic to a g × g grid.
Data models for metrics-based project management systems

A metrics based project management system (MPMS) integrates software metrics data, management queries based on the software metrics data, as well as their responses in a single location. Given the variations in projects, queries, metrics and physical databases to be used, MPMSes should be flexible from a user point of view, and also generic from a designer point of view. Two important steps in the design of an MPMS involve the determination of typical queries that may be posed by users, as well as the selection of the physical database for storing metrics and other project related knowledge. The paper discusses the relative advantages and drawbacks of three selected physical database models, namely the relational data model, object oriented data model, and graph data model, based on a variety of classes of metrics based queries. We conclude that the choice of data model varies according to the class of queries, and has strong implications on the ease and efficiency with which metrics based queries may be posed and executed.
Comment on "Measured Saturation Vapor Pressures of Phenolic and Nitro-Aromatic Compounds".

Nitro-Aromatic Compounds” I a commendable effort to increase the empirical database on the volatility of multifunctional compounds of atmospheric relevance, Bannan et al. measured the saturation vapor pressure of glutarimide, and several substituted benzenes and naphthalenes and compared them with predictions from a number of group contribution methods. The purpose of this correspondence is (1) to raise the possibility that some of the reported data are inaccurate, (2) to report predictions based on a quantum chemistry based method, and (3) to advocate the use of partitioning coefficients instead of vapor pressure for predicting the gas-particle partitioning of atmospherically relevant compounds.
Anti-Ramsey Numbers of Subdivided Graphs

Given a positive integer n and a family F of graphs, the anti-Ramsey numberf(n, F) is the maximum number of colors in an edge-coloring of Kn such that no subgraph of Kn belonging to F has distinct colors on its edges. The Turan numberex(n, F) is the maximum number of edges of an n-vertex graph that does not contain a member of F as a subgraph. P. Erdo? s et al. (1975, in Colloq. Math. Soc. Janos Bolyai, Vol. 10, pp. 633? 643, North-Holland, Amsterdam) showed for all graphs H that f(n, H)? ex(n, H)=o(n2), where H={H? e:e? E(H)}. We strengthen their result for the class of graphs in which each edge is incident to a vertex of degree two. We show that f(n, H)? ex(n, H)=O(n) when H belongs to this class. This follows from a new upper bound on f(n, H) that we prove for all graphs H and asymptotically determines f(n, H) for certain graphs H.
Implementation reuse and inheritance in distributed component systems

Software components are elemental units of software that can be realised within distributed, object oriented architectures such as CORBA or DCOM. The paper describes special aspects of reuse in such componentware architectures and discusses possible mechanisms for implementation reuse. It introduces the concept of Component Adapters-software components mapping requests of client components to appropriate implementations provided by server components. These support the realisation of implementation inheritance at object level (dynamic inheritance). A management architecture is described which supports dynamic inheritance. This includes managing and maintaining a system wide "object schema" for inter component inheritance relationships.
Injuries and falls among adults with intellectual disability: A prospective New Zealand cohort study

Abstract Background Falls and fall-related injuries are a problem for many adults with intellectual disability. Most previous studies have collected falls data retrospectively, using organisational incident reports. We developed tools to specifically collect fall-related data and potential fall risk data. This paper reports on the development of these tools and the fall-related data collected in 3 prospective studies. Method Consultations with 33 stakeholders representing 29 organisations and 5 focus group discussions were used to develop 2 tools for gathering information. Studies in 3 cities applied the tools to explore their acceptability, utility, and cultural appropriateness. Results Two simple tick box forms were developed; both were easy and quick to complete. In the studies, 135 individuals participated (70 males, 65 females, aged 45 [SD = 11] years), of whom 27% experienced a fall; 39% of these resulted in an injury. Injuries were mostly bruises (30%) and grazes (28%), particularly to the facial area (42%). The 6-month period prevalence of falls was 0.76%. Most falls occurred indoors and during the daytime. Individuals appeared more likely to experience a fall if they had had previous falls and/or fractures, epilepsy, orthopaedic-related conditions, and problems with gait and balance. Conclusion A robust process ensured the acceptability, utility, face and content validity, and cultural safety of our data collection tools. Falling is a serious problem for many people with intellectual disability, but the reasons for falling appear multifaceted and complex, complicating the development of fall prevention programs.
Collective Organizations versus Relative Performance Contracts: Inequality, Risk Sharing, and Moral Hazard

Abstract This paper studies collective economic organizations that share risk and mitigate moral hazard and compares them with relative performance contracts. Information-constrained optimal distributions of organizations and contracts are shown to be functions of the underlying primitives, in particular, the distribution of Pareto weights, and hence degree of inequality. Internal inequality of a potential, local group is a force for collective organization. That is, multi-agent organizations exist in order to extract wealth from some but not necessarily all members. The group organization is also shown to be information-constrained Pareto optimal at extremes of local wealth relative to an outsider. But the group organization is susceptible to both agents simultaneously deviating, colluding against the outsider, and this distortion makes an individualistic, relative performance contract an attractive alternative. More generally, organizations, contracts, and allocations are jointly determined. These implications could be distinguished in cross-sectional, time series data. Journal of Economic Literature Classification Numbers: D70, D82.
Improving Subject Recruitment, Retention, and Participation in Research through Peplau’s Theory of Interpersonal Relations

Recruitment and retention of persons participating in research is one of the most significant challenges faced by investigators. Although incentives are often used to improve recruitment and retention, evidence suggests that the relationship of the patient to study personnel may be the single, most important factor in subject accrual and continued participation. Peplau’s theory of interpersonal relations provides a framework to study the nurse-patient relationship during the research process. In this paper the authors provide a brief summary of research strategies that have been used for the recruitment and retention of subjects and an overview of Peplau’s theory of interpersonal relations including its use in research studies. In addition, a discussion of how this theory was used for the successful recruitment and retention of women with type 2 diabetes who participated in a clinical trial using a nurse-delivered psychoeducational intervention for depression is addressed.
An empirical study of software productivity

We studied productivity in a real-life environment in the Italian public administration by applying the goal/question/metrics paradigm to define a productivity related measurement goal and derive measures that were deemed relevant to reach the stated goal. Productivity was studied from both a functional and a product size perspectives. Our study has highlighted a few factors that are related to either aspect of productivity. The results may provide software managers with support for evaluating and improving software processes, so they can make decisions based on more quantitative information.
Research Based on the Roy Adaptation Model

Two key events lead to the prominence of links among Roy’s grand theory, derived middle-range theories and the design of research. The author in this column describes this work in two formats. Essential details of two areas of research are presented in episodic form—the first is work on secondary analysis of Roy model-based research over 40 years and the author’s study of persons’ cognitive recovery from mild head injury. The second is a project on re-conceptualizing coping and adaptation processing in sequential detail within the context of work in the field and the significance of on-going work for nursing practice.