Miracle-dz/UniFAR-FTUs huggingface dataset:
A New Fault Area Based Method of PMU Configuration and Fault Location for Large Power Grid

A fault area based PMU configuration and fault location method is proposed.According to the system observability based requirement on PMU during the fault process,the fault configuration areas of the whole power grid under assumptive faults are partitioned,and the fault configuration area based integer linear programming of PUM is carried out.When fault occurs in power grid,according to responses of additional differential currents in all fault areas the real-time fault area can be determined,and the virtual current method is used in real-time fault areas to accurately locate the fault.Case analysis shows that the proposed method can realize the topological system observability of faulty network by the configuration with a few PMUs to provide the reference for the construction of reliable and economic monitoring system of a strong power grid;the fast response of fault areas makes it possible to rapid lock the faulty zone and to prevent the maloperation due to cascaded trip out.The proposed fault location technique is suitable to various types of faults and fault positions as well as to various structures of transmission lines.
Induction of apoptosis in human colorectal cancer cells by nanovesicles from fingerroot (Boesenbergia rotunda (L.) Mansf.)

Colorectal cancer is the leading cause of cancer-related deaths worldwide, warranting the urgent need for a new treatment option. Plant-derived nanovesicles containing bioactive compounds represent new therapeutic avenues due to their unique characteristics as natural nanocarriers for bioactive molecules with therapeutic effects. Recent evidence has revealed potential anticancer activity of bioactive compounds from Boesenbergia rotunda (L.) Mansf. (fingerroot). However, the effect and the underlying mechanisms of fingerroot-derived nanovesicles (FDNVs) against colorectal cancer are still unknown. We isolated the nanovesicles from fingerroot and demonstrated their anticancer activity against two colorectal cancer cell lines, HT-29 and HCT116. The IC50 values were 63.9 ± 2.4, 57.8 ± 4.1, 47.8 ± 7.6 μg/ml for HT-29 cells and 57.7 ± 6.6, 47.2 ± 5.2, 34 ± 2.9 μg/ml for HCT116 cells at 24, 48, and 72 h, respectively. Interestingly, FDNVs were not toxic to a normal colon epithelial cell line, CCD 841 CoN. FDNVs exhibited selective uptake by the colorectal cancer cell lines but not the normal colon epithelial cell line. Moreover, dose- and time-dependent FDNV-induced apoptosis was only observed in the colorectal cancer cell lines. In addition, reactive oxygen species levels were substantially increased in colorectal cancer cells, but total glutathione decreased after treatment with FDNVs. Our results show that FDNVs exhibited selective anticancer activity in colorectal cancer cell lines via the disruption of intracellular redox homeostasis and induction of apoptosis, suggesting the utility of FDNVs as a novel intervention for colorectal cancer patients.
Microbiome therapeutics: exploring the present scenario and challenges

Abstract Human gut-microbiome explorations have enriched our understanding of microbial colonization, maturation, and dysbiosis in health-and-disease subsets. The enormous metabolic potential of gut microbes and their role in the maintenance of human health is emerging, with new avenues to use them as therapeutic agents to overcome human disorders. Microbiome therapeutics are aimed at engineering the gut microbiome using additive, subtractive, or modulatory therapy with an application of native or engineered microbes, antibiotics, bacteriophages, and bacteriocins. This approach could overcome the limitation of conventional therapeutics by providing personalized, harmonized, reliable, and sustainable treatment. Its huge economic potential has been shown in the global therapeutics market. Despite the therapeutic and economical potential, microbiome therapeutics is still in the developing stage and is facing various technical and administrative issues that require research attention. This review aims to address the current knowledge and landscape of microbiome therapeutics, provides an overview of existing health-and-disease applications, and discusses the potential future directions of microbiome modulations.
MONITORING AND ANALYSIS OF IN-FIELD GRAIN HANDLING OPERATIONS

Grain harvesting and handling operations have increased in complexity as a result of higher combine work rates requiring more efficient transfer and transport of grain out of the field. Adding to this complexity is the use of multiple units in the same field. Monitoring the behavior and interaction of the machines in the field leads to a better understanding of underlying rules that operators use to achieve optimum machine utilization. The objective of this study was to collect and analyze data from combines, grain carts and transport trucks using GPS, crop yield and discrete event data logging and to evaluate machine and operator performance characteristics. The harvesting operation focused on two combines and one grain cart harvesting corn. Data from two harvested fields were selected for analysis. In the first field the harvesting pattern, and the time spent harvesting, turning, unloading and stopping were analyzed for the two combines. In the second field the movement of the single grain cart in the field while following and unloading two combines was investigated. A system of electronic flags entered into a data logger by the operator in the respective machines was implemented to designate the start and end of grain bin filling and emptying intervals. It was concluded that optimization of the harvesting and combine unloading patterns could increase harvesting efficiency substantially.
Optimized Contour-parallel Offset Tool-path Linking Method Based on Free Region

To solve the problem of Contour-parallel offset (CPO) tool-path linking, A simple and effective CPO tool-path linking method is proposed with the help of well-known ldivideand- conquerr thought, in this method, In order to effectively organize tool-path loops (TPLs), a tree-liked data structure called lTool-path region treer (TRT) is resorted to. To obtain subpaths, At first, TRT is split into several tool-path clusters , and then their TPLs are linked by to a sub-path．After sub-paths are generated, sub-paths linking problem is optimized by replacing pre-drilling holes with slotting that is implemented by searching slotting point using the information of free region．Finally, a simulation is conducted to verify the validity of this method. The result shows that it can significantly minimize and sometimes can even eliminate tool-retractions on the basis of improving computational efficiency.
Exploring the relationship between women’s experience of postnatal care and reported staffing measures: An observational study

Background : Women have reported dissatisfaction with care received on postnatal wards and this area has been highlighted for improvement. Studies have shown an association between midwifery staffing levels and postnatal care experiences, but so far, the influence of registered and support staff deployed in postnatal wards has not been studied. This work is timely as the number of support workers has increased in the workforce and there has been little research on skill mix to date. Methods : Cross sectional secondary analysis including 13,264 women from 123 postnatal wards within 93 hospital Trusts. Staffing was measured at organisational level as Full Time Equivalent staff, and at ward level using Care Hours Per Patient Day. Womens experiences were assessed using four items from the 2019 national maternity survey. Multilevel logistic regression models were used to examine relationships and adjust for maternal age, parity, type of birth, medical staff and number of births per year in the Trust. Results: Trusts with higher levels of midwifery staffing had higher rates of women reporting positive experiences of postnatal care. However, when staffing was measured at a ward level, there was no evidence of an association between registered staffing and patient experience. Wards with higher levels of support worker staffing were associated with higher rates of women reporting they had help when they needed it and were treated with kindness and understanding. Conclusion: The relationship between reported registered staffing levels on postnatal wards and womens experience is uncertain. Further work should be carried out to examine why relationships observed at an organisational level were not replicated closer to the patient, at ward level. It is possible that reported staffing levels do not reflect staff as deployed if midwives are floated to cover delivery units. This study highlights the potential contribution of support workers in providing quality care on postnatal wards.
Dengue-2 Cosmopolitan genotype detection and emergence in South America.

We report the first confirmed case of DENV-2 Cosmopolitan genotype isolated from a male patient from Aparecida de Goiania, Goias state, Midwest Brazil. Using nanopore sequencing, and phylogenetic analyses our findings provide the first preliminary insight regarding the introduction of this emerging genotype in Brazil and South America.
Hematopoietic and Lung Platelet Biogenesis as a Prognostic Indicator in Idiopathic Pulmonary Fibrosis

Rationale and objectives The role of human lung megakaryocytes in homeostasis and their dynamics in disease states remain unknown. We sought to investigate whether megakaryocyte/platelet gene signatures are altered in IPF. Methods We analyzed publicly available transcriptome datasets of lung tissue, bronchoalveolar lavage (BAL) cells, and peripheral whole blood from IPF patients and healthy controls. Enrichment of megakaryocyte and platelet gene signatures in those datasets were estimated using xCell, a novel computational method. Furthermore, we analyzed whether mean platelet volume (MPV) and platelet counts in peripheral blood are associated with lung transplant-free survival in our IPF cohort. Results In lung tissue, megakaryocyte scores were significantly lower in IPF than in controls. In BAL cells, platelet scores were significantly lower in IPF than in controls, and lower platelet scores were associated with lower lung transplant-free survival in IPF. In contrast, in blood, megakaryocyte scores were significantly higher in IPF than in controls, and higher megakaryocyte scores were associated with lower disease progression-free survival in IPF. Furthermore, higher MPV was associated with lower transplant-free survival in our IPF cohort, independent of age, sex, forced vital capacity (FVC), and diffusing capacity of the lung for carbon monoxide (DLCO). Conclusions In IPF, megakaryocyte/platelet gene signatures were altered in a compartment-specific manner. Moreover, those signatures and MPV in blood were associated with important clinical outcomes such as transplant-free survival. These findings provide new insights into altered megakaryocyte/platelet biogenesis in IPF and suggest the potential utility of megakaryocyte/platelet-based biomarkers in IPF.
Patient perceptions by race of educational animations about living kidney donation made for a diverse population

Introduction: This qualitative study sought to identify potential design and delivery alterations to inform cultural adaptation of educational animations about living donor kidney transplantation (LDKT) - previously developed for a diverse population - to better fit Black Americans needs. Methods: We conducted a secondary analysis of 88 transcripts derived from interviews and focus groups conducted with diverse target users (62 kidney failure patients, 36 prior/potential donors, and 11 care partners) to develop 12 animations about LDKT, named KidneyTIME. Statements were abstracted and coded pertaining to cognitive and communication barriers to LDKT, and the perceived value of using the videos to learn and share the information with social network members using content analysis. Incidence counts of each content code were also calculated to assess differences between Black and non-Black patients. Results: Cognitive barrier codes included lack of knowledge, ambivalence, and concern for donor. Communication barrier codes included reluctance and difficulty talking about LDKT. Cognitive facilitating codes included attention-getting, efficient learning, manageable content, emotional impact, and new knowledge. Communication facilitating codes included delivery through many dissemination channels and broadly shareable. Compared to non-black patients (n=33) Black patients (n=29) more often stated concern for donor and reluctance/difficulty talking about LDKT as barriers, and less often stated efficient learning and manageable content as facilitators. Conclusion: Findings highlight the value of LDKT informational content that is visually appealing, digestible, non-threatening, and highly shareable. Heterogeneity may exist when considering access and intervention preferences in using KidneyTIME videos and highlight a potential for further cultural targeting or tailoring.
Pengaruh Strategi Biaya Rendah dan Diferensiasi terhadap Keberhasilan PT Tahu Tauhid

This study discusses the company PT TAHU TAUHID Lembang in the city, the researchers are interested in doing research on this company, as the company is one part of the changes to the types of food in the know begin by providing a variety of flavors to him. The factory is well know for success in business, the company's emphasis on increasing the efficiency and utilization of external circumstances, while also maintaining its uniqueness PT TAHU TAUHID. To the authors to take the title of the thesis about Influence Strategies (Low Cost and Differentiation) the success of the business. The purpose of this study was to determine a low cost to determine the success of PT TAHU TAUHID Lembang, and to determine the differentiation strategy of competitive advantage held by PT TAHU TAUHID Lembang. In the sampling method nonprobability sampling is saturated with 75 employees. The results from 75 employees to prove that the competitive advantage of Differentiation shows more influence on the success of its PT TAHU TAUHID, whereas Low cost does not significantly affect the success of PT TAHU TAUHID. Keywords: Strategies Competitive Advantage, Low Cost, Differentiation, The success of the business.
Application of 18 F‑FDG brain PET for survival prediction in a rat model of hanging‑induced hypoxic brain injury

Background Accurate prediction of survival outcomes after hanging is a crucial and challenging issue in comatose survivors. In this preclinical study, we evaluated the potential utility of using brain glucose metabolism as measured by fluorine-18-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography (PET) for survival prediction in a rat model of hanging-induced hypoxic brain injury (HBI). Methods HBI was induced by mechanical hanging using Sprague Dawley rats. 18 F-FDG brain PET images were acquired in 26 HBI rats three hours post-injury (3 h post-injury) and 4 controls. During the 1 month follow-up period, HBI rats were further classified as survivors ( n = 15) and nonsurvivors ( n = 11). Between-group regional (standardized uptake values normalized to the reference whole brain = SUVR WB , cerebellum = SUVR CB , and pons = SUVR pons ) and voxel-based analyses were performed. The prognostic value of the SUVR was tested for overall survival (OS). In addition, diffusion-weighted imaging (DWI) was performed in 2 controls and 5 HBI rats (3 survivors, 2 nonsurvivors, 3 h post), and an apparent diffusion coefficient (ADC) map was generated. The nonsurvivor group showed a significantly lower SUVR WB , SUVR CB , and SUVR pons of the cerebral cortices than the survivor group (all p < 0.001). Voxel-based comparison also demonstrated significant reduction in the nonsurvivor group compared with the survivor group (family-wise error-corrected p < 0.05). However, there was no significant difference between controls and survivors. Of 3 reference regions, the SUVR pons demonstrated the largest difference between the survivor and nonsurvivor groups. With an optimal cutoff value of 1.12 (AUC 0.952, p < 0.001), the SUVR pons predicted survival outcomes with a sensitivity of 81.8% and specificity of 100%. The OS of the low SUVR pons group was significantly shorter than that the high SUVR pons group ( p < 0.001). The mean ADC values of each brain region showed no significant difference according to survival outcomes. Conclusions These results suggest the potential utility of 18 F-FDG brain PET for predicting survival in hanging-induced HBI.
Clinical Trajectories at the End of Life in Autopsy-Confirmed Dementia Patients With Alzheimer Disease and Lewy Bodies Pathologies

Background and Objectives Evaluating and understanding the heterogeneity in dementia course has important implications for clinical practice, health care decision-making, and research. However, inconsistent findings have been reported with regard to the disease courses of the 2 most common dementias: Alzheimer disease (AD) and dementia with Lewy bodies (DLB). Using autopsy-confirmed diagnoses, we aimed to examine the disease trajectories in the years before death among patients with dementia with pure AD, pure DLB, or mixed (AD and DLB) pathologies. Methods The current retrospective longitudinal study included 62 participants with autopsy-confirmed diagnoses of pure AD (n = 34), mixed AD and DLB (AD + DLB; n = 17), or pure DLB (n = 11) from the Predictors 2 Cohort Study, a prospective, clinic-based, cohort of patients with dementia. Generalized estimating equation models, with time zero at death, were used to examine the trajectory of cognition (Folstein Mini-Mental State Examination [MMSE]), function (activities of daily living [ADL]), and Dependence Scale among patients with different autopsy-confirmed diagnosis (pure AD, AD + DLB, and pure DLB). The models were adjusted for age, sex, education, and baseline features including extrapyramidal signs, MMSE, ADL, and Dependence Scale. Results The participants on average received 9.4 ± 4.6 assessments at 6-month intervals during a mean 5.4 ± 2.9 years of follow-up. The 3 groups were similar in both cognition and function status at baseline. Cognition and function were highly correlated among patients with AD + DLB but not in pure AD or pure DLB at baseline. Patients of the 3 groups all declined in both cognition and function but had different trajectories of decline. More specifically, the patients with pure DLB experienced approximately double the rate of both cognitive decline and functional decline than the patients with pure AD, and the mixed pathology group showed double the rate of functional decline as compared to pure AD. Discussion In this longitudinal study, we found that among patients with dementia, those with Lewy body pathology experienced faster cognitive and functional decline than those with pure AD pathology.
Trends in Outpatient Treatment for Depression in Survivors of Stroke in the United States, 2004–2017

Background and Objectives Depression is highly prevalent and persistent among survivors of stroke. It is unknown how treatment for depression among survivors of stroke has changed in the evolving context of stroke care and mental health care in the general US population, especially among vulnerable sociodemographic subgroups who bear higher risks for stroke and unfavorable poststroke outcomes and experience disparities in access to and quality of stroke and mental health care. The study examined temporal trends in outpatient treatment for depression among survivors of stroke in the United States between 2004 and 2017. Methods The study sample consisted of 10,243 adult survivors of stroke and 264,645 adults without stroke drawn from the Medical Expenditure Panel Survey, a nationally representative survey in the United States. Trends in outpatient treatment for depression and potential unmet needs in the stroke population, including variations across sociodemographic subgroups, were examined and compared with the nonstroke population. Results The rate of receipt of outpatient treatment for depression among survivors of stroke was 17.7% in 2004–2005 and 16.0% in 2016–2017 (adjusted odds ratio for period change [aOR] 0.90, 95% CI 0.71–1.15). Older, male, non-Hispanic Black, and Hispanic survivors of stroke were less likely to receive treatment for depression. Approximately two-thirds of survivors of stroke who screened positive for depression received no outpatient treatment during a calendar year. The sociodemographic disparities and treatment gap persisted during the study period, which differed from the nonstroke population. Among survivors of stroke who received any treatment for depression, there was a remarkable increase in use of psychotherapy (aOR 2.26, 95% CI 1.28–4.01), despite its less frequent use compared with pharmacotherapy. Discussion Although depression is common after stroke, the majority of survivors of stroke receive no treatment for depression. This gap has remained largely unchanged over past decades, with substantial sociodemographic differences. Efforts are needed to improve depression care for survivors of stroke and reduce disparities.
Infusing geriatrics in Indian Health Service general primary care clinics: Extending VA workforce development training

ABSTRACT As federal partners, the Veterans Health Administration (VA) and the Indian Health Service (IHS) agreed to share resources, such as education. The VA Geriatric Scholars Program, a workforce development program, provides one of its training programs on team-based primary care of elders to clinicians working in IHS and Tribal Health Programs. The practical impact of that training is described. A mixed methods approach was applied to the course’s evaluation survey at five clinics in the Northwestern Plains, Southwest, Pacific Coast, and Alaska. Quantitative approaches assessed participants’ self-reported intention to improve recognition and assessment of common geriatric syndromes. A qualitative approach applied to open-ended text responses revealed intensions to improve team-based care. Among the 51 respondents in our sample, we found significant improvements in self-reported ability to recognize previously unfamiliar potential risks to elders’ health and safety, t(49) = 8.0233, p < . 001, as well as increased comfort with conducting geriatric assessments and increased confidence in interprofessional team-based communication. Improvements to team-based care included enhanced clinical skills, organizational factors and the need to train additional employees. This evaluation demonstrates the value of sharing resources among federal partners and its value for participants in IHS and Tribal Health Programs.
Artificial intelligence in orthopaedics surgery: transforming technological innovation in patient care and surgical training

Artificial intelligence (AI) is an exciting field combining computer science with robust data sets to facilitate problem-solving. It has the potential to transform education, practice and delivery of healthcare especially in orthopaedics. This review article outlines some of the already used AI pathways as well as recent technological advances in orthopaedics. Additionally, this article further explains how potentially these two entities could be combined in the future to improve surgical education, training and ultimately patient care and outcomes.