Miracle-dz/UniFAR-FTUs huggingface dataset:
Approximation Hardness for A Class of Sparse Optimization Problems

In this paper, we consider three typical optimization problems with a convex loss function and a nonconvex sparse penalty or constraint. For the sparse penalized problem, we prove that finding an O(n1d2)-optimal solution to an n × d problem is strongly NP-hard for any c1, c2 ∈ [0, 1) such that c1 + c2 < 1. For two constrained versions of the sparse optimization problem, we show that it is intractable to approximately compute a solution path associated with increasing values of some tuning parameter. The hardness results apply to a broad class of loss functions and sparse penalties. They suggest that one cannot even approximately solve these three problems in polynomial time, unless P = NP.
Poignancy and Mediated Wisdom of Experience: Narrative Impacts on Willingness to Accept Delayed Rewards

Research on the impact of eudaimonic narrative has begun to identify a variety of psychologically and socially important outcomes. In the present study, we conceptually and operationally distinguish three distinctive responses to eudaimonic narrative: moral elevation, being emotionally moved, and poignancy. We, following work by Hershfield and colleagues (Ersner-Hershfield, Mikels, Sullivan, & Carstensen, 2008), suggest that poignancy, or a combination of sadness and happiness in response to life or narrative events, represents a recognition and acceptance of life’s transience and mixed joys and sorrows. Evocation of poignancy by eudaimonic narrative, then, should elicit responses associated with age, life experience, and maturity, which we refer to as “mediated wisdom of experience. ” We find that brief eudaimonic video clips, compared with similar non-eudaimonic clips, increase acceptance of delayed rewards (i.e., reduced delay discounting, which has been found to be associated with maturity and negatively associated with risky and unsafe behavior in prior research), indirectly via the impact of these clips on poignant responses. In contrast, being emotionally moved showed an indirect path leading to decreased acceptance of delayed rewards, whereas moral elevation had no mediating effect.
Trust in Ad Hoc Networks: A New Model Based on Clustering Algorithm

An Mobile Ad-hoc network (MANET) is formed when group of mobile wireless nodes collaborate between them to communicate through wireless links in the absence of the ﬁxed infrastructure and any centralized control. This paper focuses on the design a self-stabilizing clustering algorithm in MANETs. The Topology that we propose is a partitioning based on trust between members of a group. It forms a structure able to adapt dynamically to changes in the topology. Some cryptographic-based schemes have been proposed to secure the clustering process, but they are unable to handle the internal attacks. To defend against insider malicious nodes, trust and reputation management systems should be used . Our solution is based on our eﬃcient trust model and distributed al-gorithm to clustering network.We present our clustering approach based on trust for applications in the ﬁeld of security.
Endogenous amylin contributes to birth of microglial cells in arcuate nucleus of hypothalamus and area postrema during fetal development.

Amylin acts in the area postrema (AP) and arcuate nucleus (ARC) to control food intake. Amylin also increases axonal fiber outgrowth from the AP→nucleus tractus solitarius and from ARC→hypothalamic paraventricular nucleus. More recently, exogenous amylin infusion for 4 wk was shown to increase neurogenesis in adult rats in the AP. Furthermore, amylin has been shown to enhance leptin signaling in the ARC and ventromedial nucleus of the hypothalamus (VMN). Thus, we hypothesized that endogenous amylin could be a critical factor in regulating cell birth in the ARC and AP and that amylin could also be involved in the birth of leptin-sensitive neurons. Amylin+/- dams were injected with BrdU at embryonic day 12 and at postnatal day 2; BrdU+ cells were quantified in wild-type (WT) and amylin knockout (KO) mice. The number of BrdU+HuC/D+ neurons was similar in ARC and AP, but the number of BrdU+Iba1+ microglia was significantly decreased in both nuclei. Five-week-old WT and KO littermates were injected with leptin to test whether amylin is involved in the birth of leptin-sensitive neurons. Although there was no difference in the number of BrdU+c-Fos+ neurons in the ARC and dorsomedial nucleus, an increase in BrdU+c-Fos+ neurons was seen in VMN and lateral hypothalamus (LH) in amylin KO mice. In conclusion, these data suggest that during fetal development, endogenous amylin favors the birth of microglial cells in the ARC and AP and that it decreases the birth of leptin-sensitive neurons in the VMN and LH.
Perceptions of Sexual Orientation and Gender Identity Minority Adolescents About Labels

Young peoples’ acceptance and use of nontraditional, descriptive identity labels (e.g., pansexual, genderqueer) require nurses to consider moving beyond use of traditional terms (e.g., gay, transgender). This mixed methods study explores (a) labels used by sexual orientation and gender identity (SOGI) minority youth, (b) their expressed importance and meaning of these labels, and (c) differences in label usage. Sixty-six SOGI minority adolescents in British Columbia, Minnesota, and Massachusetts (mean age = 16.6) participated in “go-along” interviews; during interviews, 42 (63.6%) commented on labels. Chi-square and t tests were used to compare traditional versus nontraditional labels across participant demographic categories. Inductive thematic analysis was used to identify representative themes. Approximately, 1/3 of participants used nontraditional sexual orientation identity labels; this finding was associated with a trans identity and nontraditional gender labels. Using terminology that is meaningful and representative to the youth themselves has potential to facilitate representative research and welcoming environments in practice.
Evidence of Sharing of Klebsiella pneumoniae Strains between Healthy Companion Animals and Cohabiting Humans

This study aimed to characterize the fecal colonization and sharing of Klebsiella pneumoniae strains between companion animals and humans living in close contact. Fecal samples were collected from 50 healthy participants (24 humans, 18 dogs, and 8 cats) belonging to 18 households. ABSTRACT This study aimed to characterize the fecal colonization and sharing of Klebsiella pneumoniae strains between companion animals and humans living in close contact. Fecal samples were collected from 50 healthy participants (24 humans, 18 dogs, and 8 cats) belonging to 18 households. Samples were plated onto MacConkey agar (MCK) plates with and without cefotaxime or meropenem supplementation. Up to five K. pneumoniae colonies per participant were compared by pulsed-field gel electrophoresis (PFGE) after XbaI restriction. K. pneumoniae strains with unique pulse types from each participant were characterized for antimicrobial susceptibility, virulence genes, and multilocus sequence type (MLST). Fecal K. pneumoniae pulse types were compared to those of clinical K. pneumoniae strains from animal and human patients with urinary tract infections (n = 104). K. pneumoniae colonization was detected in nonsupplemented MCK in around 38% of dogs (n = 7) and humans (n = 9). K. pneumoniae strains isolated from dogs belonged to sequence type 17 (ST17), ST188, ST252, ST281, ST423, ST1093, ST1241, ST3398, and ST3399. None of the K. pneumoniae strains were multidrug resistant or hypervirulent. Two households included multiple colonized participants. Notably, two colonized dogs within household 15 (H15) shared a strain each (ST252 and ST1241) with one coliving human. One dog from H16 shared one PFGE-undistinguishable K. pneumoniae ST17 strain with two humans from different households; however, the antimicrobial susceptibility phenotypes of these three strains differed. Two main virulence genotypes were detected, namely fimH-1 mrkD ycfM entB kfu and fimH-1 mrkD ycfM entB kpn. These results highlight the potential role of dogs as a reservoir of K. pneumoniae to humans and vice versa. Furthermore, to our best knowledge, this is the first report of healthy humans and dogs sharing K. pneumoniae strains that were undistinguishable by PFGE/MLST.
Exploring Patient Decision Making Regarding Discontinuation of Tyrosine Kinase Inhibitors for Chronic Myeloid Leukemia.

BACKGROUND The standard treatment for chronic phase chronic myeloid leukemia (CML) is lifelong oral tyrosine kinase inhibitor (TKI) therapy. Multiple clinical trials have demonstrated that some patients with a sustained deep molecular response to TKI therapy can safely stop therapy and remain in a treatment-free remission. TKI discontinuation is now offered to select patients in routine clinical care. In order to better support patient decision making, we explored patients' views on TKI discontinuation and the factors patients consider when making this decision. MATERIALS AND METHODS Patients were recruited from three U.S. academic cancer centers. Qualitative interviews were recorded, transcribed, and content analyzed. RESULTS We interviewed 22 patients, half of whom wanted to try TKI discontinuation. Eleven factors relevant to the decision emerged, and patients weighed these factors differently. Commonly mentioned factors included perceived risk of relapse, TKI side effects, financial considerations, polypharmacy, and willingness to change something that was working (status quo). There were notable differences in patients' understanding of the likelihood of achieving a treatment-free remission, with patients who did not want to stop TKIs more accurately reporting the risk of relapse than patients who wanted to stop. CONCLUSION This is a novel decision that will become more common as the prevalence of patients with well-controlled CML continues to increase. These results highlight the need for patient education and decision support so that patients and providers can make shared decisions that are informed and values based. IMPLICATIONS FOR PRACTICE The standard treatment for chronic phase chronic myeloid leukemia (CML) is lifelong oral tyrosine kinase inhibitor (TKI) therapy. Clinical trials have shown that some patients with a sustained deep molecular response to TKI therapy can safely stop therapy and remain in a treatment-free remission. TKI discontinuation is now being offered to patients outside of clinical trials. This study explored factors that patients who are eligible to try TKI discontinuation considered when making this decision. Factors relevant to the decision included risk of relapse, side effects, financial considerations, polypharmacy, and willingness to change something that was working. This is a novel decision that will become more common as the prevalence of patients with well-controlled CML continues to increase. These results highlight the need for decision support and outline the factors that should be included so that patients and providers can make shared decisions that are informed and values based.
Minority and majority pre-treatment HIV-1 drug resistance associated with failure of 1st-line NNRTI ART in Kenyan women.

OBJECTIVES Among women initiating 1-line non-nucleoside-reverse-transcriptase-inhibitor-(NNRTI)-based-ART with-and-without a history of single-dose-nevirapine-(sdNVP)±zidovudine±lamivudine (ZDV±3TC) for prevention-of-mother-to-child-HIV-transmission (PMTCT), we hypothesized that pre-ART HIV-drug-resistance would be associated with virologic failure DESIGN/METHODS:: In a prospectively enrolled study, three genotypic drug-resistance assays (oligonucleotide-ligation-assay (OLA), consensus sequencing, and next-generation-sequencing by Illumina) were retrospectively performed to detect pre-ART drug-resistance. Minority or majority drug-resistant variants identified in pre-ART RNA and/or DNA, a history of antiretrovirals for PMTCT, and other risk factors were assessed for association with virologic failure. RESULTS Failure occurred in 38/169 (22.5%) women, and was associated with pre-ART drug-resistance detected by any assay (OLA of plasma or PBMC, consensus sequencing of PBMC and/or plasma, and next-generation-sequencing of PBMC at frequencies ≥10% and as minority variants; all P < 0.0001). Failure was also associated with PMTCT using sdNVP+ZDV±3TC, but not sdNVP-only; however, the longer time-interval between PMTCT and ART-initiation observed for sdNVP-only women showed no interaction with failure. Viral loads and OLA of PBMC in longitudinal specimens demonstrated rapid failure and emergence of drug-resistance, particularly among sdNVP+ZDV±3TC-experienced women with pre-ART drug-resistant minority variants by next-generation-sequencing but without drug-resistance by OLA or consensus sequencing. SUMMARY/CONCLUSIONS Pre-ART drug-resistance was detected similarly by OLA of PBMC or plasma and by consensus sequencing, and was associated with virologic failure soon after initiation of 1-line NVP-based ART. A history of sdNVP+ZDV±3TC for PMTCT or minority variants detected by next-generation-sequencing identified additional women with failure. These findings emphasize the value of assessing individual antiretroviral history, particularly non-suppressive antiretrovirals with ≥2 drug classes, and testing for pre-ART drug-resistance, including minority variants.
Growth and Late Detection of Post-Operative Cholesteatoma on Long Term Follow-Up With Diffusion Weighted Magnetic Resonance Imaging (DWI MRI): A Retrospective Analysis From a Single UK Centre.

OBJECTIVE To evaluate the growth rate and late detection of residual cholesteatoma on long-term follow-up with diffusion weighted magnetic resonance imaging (DWI MRI) in clinically stable ears following definitive surgery, in order to define surveillance imaging protocols. STUDY DESIGN Retrospective case review. SETTING Tertiary referral center. PATIENTS Patients who underwent DWI MRI at our institution between February 2007 and May 2013 for postoperative cholesteatoma follow-up. INTERVENTION Non-echo planar imaging (non-EPI) Half-Fourier Acquisition Single-shot Turbo spin Echo (HASTE) DWI MRI. MAIN OUTCOME MEASURES Intervals between the definitive surgery and the first and subsequent DWI MRI, the maximum coronal dimension of the lesion on DWI and length of follow-up. RESULTS The study evaluated 152 postoperative DWI studies performed for 88 patients. In 12 cases, DWI was initially negative but became positive on repeat imaging after a mean interval of 3.8 years from the initial cholesteatoma surgery (median 3.7 years, range 1.6-7.9). Of these, 3/12 had more than one negative/indeterminate DWI before disease was eventually detected on imaging; in this subgroup, the mean interval between surgery and positive DWI was 3.2 years (median 2.6 years, range 2.3-4.2). 39 DWI positive foci with serial imaging demonstrated a mean growth rate of 4 mm/year (median 2 mm, range 0-18). CONCLUSIONS After negative initial DWI, it is proposed that interval imaging should be considered for a minimum of 5 years in stable ears following definitive cholesteatoma surgery. In view of the marked variability in growth rate, an additional interval scan between 2 and 3 years postoperatively is indicated.
PANGEA-HIV 2: Phylogenetics And Networks for Generalised Epidemics in Africa

Purpose of review The HIV epidemic in sub-Saharan Africa is far from being under control and the ambitious UNAIDS targets are unlikely to be met by 2020 as declines in per-capita incidence being largely offset by demographic trends. There is an increasing number of proven and specific HIV prevention tools, but little consensus on how best to deploy them. Recent findings Traditionally, phylogenetics has been used in HIV research to reconstruct the history of the epidemic and date zoonotic infections, whereas more recent publications focus on HIV diversity and drug resistance. However, it is also the most powerful method of source attribution available for the study of HIV transmission. The PANGEA (Phylogenetics And Networks for Generalized Epidemics in Africa) consortium has generated over 18 000 NGS HIV sequences from five countries in sub-Saharan Africa. Using phylogenetic methods, we will identify characteristics of individuals or groups, which are most likely to be at risk of infection or at risk of infecting others. Summary Combining phylogenetics, phylodynamics and epidemiology will allow PANGEA to highlight where prevention efforts should be focussed to reduce the HIV epidemic most effectively. To maximise the public health benefit of the data, PANGEA offers accreditation to external researchers, allowing them to access the data and join the consortium. We also welcome submissions of other HIV sequences from sub-Saharan Africa to the database.
Utility of point-of-care Gram stain by physicians for urinary tract infection in children ≤36 months

Abstract Urinary tract infection (UTI) in children requires early diagnosis and treatment to prevent repeated UTI and renal scarring. This study aimed to evaluate the usefulness of the point-of-care Gram stain by physicians for suspected UTI in children at Okinawa Chubu Hospital as a rapid diagnostic test. A single-center, retrospective study was undertaken between January 2011 and December 2015. Patients aged 36 months or younger who were reviewed had suspected UTI in the emergency room or outpatient clinic. Urine culture, urinalysis, and point-of-care Gram stain were performed on a single specimen. Patients with structural or functional urological defects requiring routine catheterization were excluded. We compared the diagnostic performance among the rapid diagnostic tests (i.e., pyuria, point-of-care Gram stain, or both). Kappa statistics were used to evaluate the agreement between the results of point-of-care Gram stain and morphotypes of urine culture with the 95% CI (bias corrected bootstrap interval). We also analyzed which antibiotics were more susceptible to the bacteria of urine culture results, selected by the results of point-of-care Gram stain or empirical treatment based on the Japanese guidelines by McNemar test. Of 1594 patients reviewed in the study, 1546 were eligible according to our inclusion criteria. Using urine culture as the gold standard for UTI, the sensitivity and specificity of pyuria were 73.2% and 95.1%, whereas those of the point-of-care Gram stain were 81.4% and 98.2%, respectively. The concordance rate between the morphotypes of bacteria detected by point-of-care Gram stain and those of urine culture was 0.784 (kappa coefficient) (95% CI 0.736–0.831). Furthermore, the proportion of “susceptible” in the minimum inhibitory concentration of pathogen-targeted treatment based on the point-of-care Gram stain was higher than that of empirical therapy (exact McNemar significance probability: .0001). Our analysis suggests that the point-of-care Gram stain is a useful rapid diagnostic tool for suspected UTI in young children. Pathogen-targeted treatment based on the point-of-care Gram stain would lead to better antibiotic selection compared with empirical therapy.
Long noncoding RNA PEG10 facilitates bladder cancer cells proliferation, migration, and invasion via repressing microRNA‐29b

Long noncoding RNA paternally expressed gene 10 (lncRNA PEG10) has been certified to regulate cell proliferation, metastasis, and apoptosis in diversified cancer cells. Nevertheless, the functions of PEG10 in bladder cancer cells remain uninvestigated. We tried to probe the impacts of PEG10 on proliferation, migration, and invasion of bladder cancer cells. PEG10 expression in SV‐HUC‐1, T24, RT4, and 253J‐BV cells was estimated by quantitative reverse transcription‐polymerase chain reaction (RT‐qPCR). After pc‐PEG10 or sh‐PEG10 transfection, the impacts of PEG10 on T24 and 253J‐BV cell viability, migration, invasion, and the relevant proteins were disclosed via employing CCK‐8, Transwell, and western blot. The relevancy between miR‐29b and PEG10 was probed, and the influences of overexpressed miR‐29b in above‐mentioned cell biological processes were reassessed. Wnt/β‐catenin and JNK pathways were ultimately analyzed to unmake the underling mechanism. We found that overexpressed PEG10 facilitated cell viability and upregulated CyclinD1, CDK4, and CDK6 in T24 and 253J‐BV cells. Cell migration and invasion were also elevated by overexpressed PEG10 through the enhancement of MMP‐2, MMP‐9, and Vimentin. In addition, repressed miR‐29b was observed in PEG10‐overexpressed T24 and 253J‐BV cells. Moreover, overexpressed miR‐29b overtly overturned the carcinogenic impacts of PEG10 on T24 cells. The activations of Wnt/β‐catenin and JNK pathways were enhanced by overexpressed PEG10 via mediating miR‐29b. SP600125 (JNK inhibitor) disposition reversed the acceerative impacts of PEG10 on cell proliferation, migration, and invasion in T24 cells. In conclusion, the investigations testified that PEG10 gave play to the carcinogenic impacts on bladder cancer cells via mediating miR‐29b‐Wnt/β‐catenin‐JNK axis.
Realizations of Exceptional U-Duality Groups as Conformal and Quasi-Conformal Groups and Their Minimal Unitary Representations

We review the novel quasiconformal realizations of exceptional U-duality groups whose "quantization" lead directly to their minimal unitary irreducible representations. The group $E_{8(8)}$ can be realized as a quasiconformal group in the 57 dimensional charge-entropy space of BPS black hole solutions of maximal N=8 supergravity in four dimensions and leaves invariant "lightlike separations" with respect to a quartic norm. Similarly $E_{7(7)}$ acts as a conformal group in the 27 dimensional charge space of BPS black hole solutions in five dimensional N=8 supergravity and leaves invariant "lightlike separations" with respect to a cubic norm. For the exceptional N=2 Maxwell-Einstein supergravity theory the corresponding quasiconformal and conformal groups are $E_{8(-24)}$ and $E_{7(-25)}$, respectively. These conformal and quasiconformal groups act as spectrum generating symmetry groups in five and four dimensions and are isomorphic to the U-duality groups of the corresponding supergravity theories in four and three dimensions, respectively. Hence the spectra of these theories are expected to form unitary representations of these groups whose minimal unitary realizations are also reviewed.