Miracle-dz/UniFAR-FTUs huggingface dataset:
The Reflectance of Human Skin in the Millimeter-Wave Band

The millimeter-wave band is an ideal part of the electromagnetic radiation to diagnose human skin conditions because this radiation interacts only with tissue down to a depth of a millimetre or less over the band range from 30 GHz to 300 GHz. In this paper, radiometry is used as a non-contact sensor for measuring the human skin reflectance under normal and wet skin conditions. The mean reflectance of the skin of a sample of 50 healthy participants over the (80–100) GHz band was found to be ~0.615 with a standard deviation of ~0.088, and an experimental measurement uncertainty of ±0.005. The thinner skin regions of the back of the hand, the volar forearms and the inner wrist had reflectances 0.068, 0.068 and 0.062 higher than the thicker skin regions of the palm of the hand, the dorsal forearm and the outer wrist skin. Experimental measurements of human skin reflectance in a normal and a wet state on the back of the hand and the palm of the hand regions indicated that the mean differences in the reflectance before and after the application of water were ~0.078 and ~0.152, respectively. These differences were found to be statistically significant as assessed using t-tests (34 paired t-tests and six independent t-tests were performed to assess the significance level of the mean differences in the reflectance of the skin). Radiometric measurements in this paper show the quantitative variations in the skin reflectance between locations, sexes, and individuals. The study reveals that these variations are related to the skin thickness and water content, a capability that has the potential to allow radiometry to be used as a non-contact sensor to detect and monitor skin conditions such as eczema, psoriasis, malignancy, and burn wounds.
An Observational Tool to Assess Activity Limitation in Ambulatory People with Cerebral Palsy When Performing Motor Skills

Ratios of physical activity and sports participation in people with cerebral palsy (CP) are still low compared with people without a disability. For an adequate and useful practice, physical activity professionals should understand how different types of CP profiles constrain the performance of motor skills that are required during sports practice. This study aims to develop an observation-based assessment tool to evaluate activity limitations in individuals with a moderate level of CP when performing skills requiring jumping, sprinting, change of direction, coordination, and balance. Nineteen observers with different backgrounds from five world regions were recruited for this study, with accredited experience classifying/observing para-athletes with CP. All observers watched videos of 20 international para-athletes with different CP profiles (bilateral spasticity, athetosis/ataxia, unilateral spasticity; all Gross Motor Function Classification System level I) performing 16 motor tasks, and their observations were recorded throughout an ad-hoc data collection instrument. A total of 6080 units of qualitative information were recorded for data analysis. An observation-based tool with qualitative descriptors is derived from data analyses, describing how coordination and balance affected mainly in those with dyskinesia/ataxia, range of movement in those with diplegia, and asymmetries in those with hemiplegia. This tool would help sports practitioners and physical educators to better understand how different CP profiles constrain the performance of motor skills.
Grazing Seasons and Stocking Rates Affects the Relationship between Herbage Traits of Alpine Meadow and Grazing Behaviors of Tibetan Sheep in the Qinghai–Tibetan Plateau

Simple Summary The relationship between vegetation and grazing behavior of Tibetan sheep on the Qinghai–Tibetan Plateau (QTP) remains a major concern for pursuing the sustainable grazing management of grassland. Grazing behavior is the daily activity of grazing livestock, which can reflect the growth status of the pasture and the level of grassland health in the local pasture, as well as the nutritional needs of Tibetan sheep. We studied the relationship between the grazing behaviors of Tibetan sheep and the quantity and quality of forage in different seasons and different stocking rates. Our results showed that the grazing behavior of Tibetan sheep was greatly affected by the quantity and nutritional quality of the forage. These results may be helpful for local herders to evaluate the nutritional status of forage and condition of grassland degradation, so that appropriate measures can be taken to protect local pastures in advance. Abstract Under the combined effect of stocking rate and grazing season, it is very significant to ascertain whether there is a quantitative relationship between plant community characteristics, chemical composition of forage, and grazing behaviors of Tibetan sheep to better utilize native pasture in the northeast region of the Qinghai–Tibetan Plateau (QTP). The two consecutive year observation experiments on Tibetan sheep’s grazing behavior were conducted to evaluate the above-stated relationships between stocking rates of 8 sheep/ha and 16 sheep/ha stocking rates in the both the warm and cold seasons. The results demonstrated that at 8 sheep/ha or in the warm season, due to better forage quality, Tibetan sheep had higher herbage mass, forage crude protein (CP) concentration, CP intake, dry matter intake (DMI), and interval between feed boluses and total number of steps, as well as lower fiber concentration than that at 16 sheep/ha or in the cold season. Diurnal intake rate and walking velocity while intaking increased as both average daylight ambient temperature and relative humidity rose. Using the CP concentration, acid detergent fiber (ADF) concentration, neutral detergent fiber (NDF) concentration, and forage metabolic energy (ME) to predict grazing behavior yielded the best fit equation for Tibetan sheep. For local herdsmen to sustainably use the alpine meadow, 8 sheep/ha in the warm season should be considered as the better grazing condition for preventing grassland degradation.
miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation

During the development of the central nervous system, the proliferation of neural progenitors and differentiation of neurons and glia are tightly regulated by different transcription factors and signaling cascades, such as the Wnt and Shh pathways. This process takes place in cooperation with several microRNAs, some of which evolutionarily conserved in vertebrates, from teleosts to mammals. We focused our attention on miR-7, as its role in the regulation of cell signaling during neural development is still unclear. Specifically, we used human stem cell cultures and whole zebrafish embryos to study, in vitro and in vivo, the role of miR-7 in the development of dopaminergic (DA) neurons, a cell type primarily affected in Parkinson’s disease. We demonstrated that the zebrafish homologue of miR-7 (miR-7a) is expressed in the forebrain during the development of DA neurons. Moreover, we identified 143 target genes downregulated by miR-7, including the neural fate markers TCF4 and TCF12, as well as the Wnt pathway effector TCF7L2. We then demonstrated that miR-7 negatively regulates the proliferation of DA-progenitors by inhibiting Wnt/β-catenin signaling in zebrafish embryos. In parallel, miR-7 positively regulates Shh signaling, thus controlling the balance between oligodendroglial and DA neuronal cell fates. In summary, this study identifies a new molecular cross-talk between Wnt and Shh signaling pathways during the development of DA-neurons. Being mediated by a microRNA, this mechanism represents a promising target in cell differentiation therapies for Parkinson’s disease.
Modified Iliotibial Band Tenodesis Is Indicated to Correct Intraoperative Residual Pivot Shift After Anterior Cruciate Ligament Reconstruction Using an Autologous Hamstring Tendon Graft: A Prospective Randomized Controlled Trial

Background: The indications for the addition of anterolateral soft tissue augmentation to anterior cruciate ligament (ACL) reconstruction and its effectiveness remain uncertain. Purpose: To determine if modified iliotibial band tenodesis (MITBT) can improve clinical outcomes and reduce the recurrence of ACL ruptures when added to ACL reconstruction in patients with a residual pivot shift. Study Design: Randomized controlled trial; Level of evidence, 2. Methods: Patients with a primary ACL rupture satisfying the following inclusion criteria were enrolled: first ACL rupture, involved in pivoting sports, skeletally mature, no meniscal repair performed, and residual pivot shift relative to the contralateral uninjured knee immediately after ACL reconstruction. Patients were randomized to group A (no further surgery) or group B (MITBT added) and were followed up for 2 years. The patient-reported outcome (PRO) measures used were the International Knee Documentation Committee (IKDC) score, Knee injury and Osteoarthritis Outcome Score (KOOS) subscale of sport/recreation (Sport/Rec), KOOS subscale of quality of life (QoL), Lysholm knee score (LKS), Tegner activity scale (TAS), recurrent ACL ruptures, or need for further surgery in either knee. Analysis of variance was used to compare PROs; the Wilcoxon test was used for the TAS; and the chi-square test was used for recurrence of ACL ruptures, meniscal injuries, and contralateral ACL ruptures (P < .05). Results: A total of 55 patients were randomized: 27 to group A (female:male ratio = 15:12; mean age, 22.3 ± 3.7 years) and 28 to group B (female:male ratio = 17:11; mean age, 21.8 ± 4.1 years). At 2-year follow-up, group A had a similar IKDC score (90.9 ± 10.7 vs 94.2 ± 11.2; respectively; P = .21), lower KOOS Sport/Rec score (91.5 ± 6.4 vs 95.3 ± 4.4, respectively; P = .02), similar KOOS QoL score (92.0 ± 4.8 vs 95.1 ± 4.3, respectively; P = .14), lower LKS score (92.5 ± 4.8 vs 96.8 ± 8.0, respectively; P = .004), lower TAS score (median, 7 [range, 7-9] vs 8 [range, 8-10], respectively; P = .03), higher rate of recurrence (14.8% vs 0.0%, respectively; P < .001), similar rate of meniscal tears (14.8% vs 3.6%, respectively; P = .14), and similar rate of contralateral ACL ruptures (3.7% vs 3.6%, respectively; P = .99) relative to group B. Conclusion: The augmentation of ACL reconstruction with MITBT reduced the risk of recurrent ACL ruptures in knees with a residual pivot shift after ACL reconstruction and improved KOOS Sport/Rec, LKS, and TAS scores. Registration: ACTRN12618001043224 (Australian New Zealand Clinical Trials Registry)
Use of Oak and Cherry Wood Chips during Alcoholic Fermentation and the Maturation Process of Rosé Wines: Impact on Phenolic Composition and Sensory Profile

There is a lack of knowledge about the use of different wood species on rosé wine production. Thus, this work focused on the impact of the addition of wood chips from oak and cherry trees during the alcoholic fermentation and maturation process on rosé wine characteristics. Therefore, phenolic composition and sensory characteristics were monitored during the rosé wines’ production. The use of wood chips during alcoholic fermentation induced a significant increase of phenolic content in rosé musts. During rosé wine maturation, the wood chip contact induced significantly higher values of colored anthocyanins, color intensity, and polymeric pigments, and significantly lower values of color hue in the corresponding rosé wines. In terms of sensory profile, a tendency for lower scores of “overall appreciation” were attributed to control rosé wine, while significantly higher scores for “color intensity” descriptor were attributed to all rosé wines matured in contact with wood chips. For the majority of phenolic parameters and individual phenolic compounds quantified, a clear and specific influence of the use of oak and cherry wood chips was not detected, except for (+)-catechin, where the rosé wines produced in contact with cherry chips showed the highest values. This study provides relevant information for winemakers about the impact of the use of wood chips on rosé wine quality.
Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity

The memory CD8 T-cell pool must select for clones that bind immunodominant epitopes with high affinity to efficiently counter reinfection. At the same time, it must retain a level of clonal diversity to allow recognition of pathogens with mutated epitopes. How the level of diversity within the memory pool is controlled is unclear, especially in the context of a selective drive for antigen affinity. We find that preservation of clones that bind the activating antigen with low affinity depends on expression of the transcription factor Eomes in the first days after antigen encounter. Eomes is induced at low activating signal strength and directly drives transcription of the prosurvival protein Bcl-2. At higher signal intensity, T-bet is induced which suppresses Bcl-2 and causes a relative survival advantage for cells of low affinity. Clones activated with high-affinity antigen form memory largely independent of Eomes and have a proliferative advantage over clones that bind the same antigen with low affinity. This causes high-affinity clones to prevail in the memory pool, despite their relative survival deficit. Genetic or therapeutic targeting of the Eomes/Bcl-2 axis reduces the clonal diversity of the memory pool, which diminishes its ability to respond to pathogens carrying mutations in immunodominant epitopes. Thus, we demonstrate on a molecular level how sufficient diversity of the memory pool is established in an environment of affinity-based selection.
Live bird markets as evolutionary epicentres of H9N2 low pathogenicity avian influenza viruses in Korea

ABSTRACT Live bird markets (LBMs) in Korea have been recognized as a reservoir, amplifier, and source of avian influenza viruses (AIVs); however, little was known about the role of LBMs in the epidemiology of AIVs in Korea until recently. Through 10 years of surveillance (2006–2016) we have isolated and sequenced H9N2 viruses in Korean LBMs. To understand how H9N2 evolves and spreads in Korea, a statistical Bayesian phylogenetic model was used. Phylogenetic analysis suggests that three separate introductions of progenitor gene pools, Korean domestic duck-origin and two wild aquatic bird-origin AIVs, contributed to the generation of the five genotypes of H9N2 viruses in Korea. Phylogenetic reconstruction of ecological states infer that the LBMs are where chickens become infected with the virus, with domestic ducks playing a major role in the transmission and evolution of the H9N2 viruses. Three increases in the genetic diversity of H9N2 viruses were observed and coincided with transitions in host species and the locations (domestic farm, LBM, slaughterhouse, and wild aquatic bird habitat) where the viruses were isolated, accompanying genetic reassortment. Following the introduction of a wild aquatic bird-origin AIVs in 2008, six genes of the Korean lineage H9N2 virus were replaced with genes originating from wild aquatic birds, and viruses with this new genotype became predominant in Korean LBMs.
YBEY is an essential biogenesis factor for mitochondrial ribosomes

Ribosome biogenesis requires numerous trans-acting factors, some of which are deeply conserved. In Bacteria, the endoribonuclease YbeY is believed to be involved in 16S rRNA 3’-end processing and its loss was associated with ribosomal abnormalities. In Eukarya, YBEY appears to generally localize to mitochondria (or chloroplasts). Here we show that the deletion of human YBEY results in a severe respiratory deficiency and morphologically abnormal mitochondria as an apparent consequence of impaired mitochondrial translation. Reduced stability of 12S rRNA and the deficiency of several proteins of the small ribosomal subunit in YBEY knockout cells pointed towards a defect in mitochondrial ribosome biogenesis. The specific interaction of mitoribosomal protein uS11m with YBEY suggests that the latter recruits uS11m to the nascent small subunit in its late assembly stage. This scenario shows similarities with final stages of cytosolic ribosome biogenesis, and may represent a late checkpoint before the mitoribosome engages in translation.
Electrochemical Oxidation of Nitrogen towards Direct Nitrate Production on Spinel Oxides.

Nitrates are widely used as fertilizer and oxidizing agents. Commercial nitrate production from nitrogen is mainly through the Haber-Bosch (H-B) process and Ostwald process, both involving high-temperature-high-pressure processes. Therefore, establishing an alternative nitrate production method under ambient environment is of paramount importance. Herein, an electrochemical nitrogen oxidation reaction (NOR) approach is developed to produce nitrate catalyzed by ZnFexCo2-xO4 spinel oxides in an alkaline electrolyte. As revealed by theoretical and experimental results, Fe is found to facilitate the formation of the first N-O bond on the *N site, while high oxidation state Co assists in stabilizing the absorbed OH- for the successful generation of the second and third N-O bonds. Owing to the concerted catalysis, the ZnFe0.4Co1.6O4 oxide demonstrates the highest nitrate production rate of 130 ± 12 μmol h-1 gMO-1 at an applied potential of 1.6 V vs. reversible hydrogen electrode (RHE). This work provides a choice for energy-efficient and environmentally friendly production of nitrate.
Performance of propensity score matching to estimate causal effects in small samples

Propensity score (PS) matching is a very popular causal estimator usually used to estimate the average treatment effect on the treated (ATT) from observational data. However, opting for this estimator may raise some efficiency issues when the sample size is limited. Therefore, we aimed to evaluate the performance of propensity score matching in this context. We started with a motivating example based on a cohort of 66 children with sickle cell anemia who received either allogeneic bone-marrow transplant or chronic transfusion. We found substantial differences in the ATT estimate according to the model selected for propensity score estimation and subsequent matching. Then, we assessed the performance of the different propensity score matching methods and post-matching analyses to estimate the ATT using a simulation study. Although all selected propensity score matching methods were based of previous recommendations, we found important discrepancies in the estimation of treatment effect between them, underlining the importance of thorough sensitivity analyses when using propensity score matching in the context of small sample sizes.
Radial contractility of actomyosin rings facilitates axonal trafficking and structural stability

Wang et al. find that axonal radial contractility and local expansion control the retrograde trafficking of large cargoes. The periodic actomyosin-II network comprises NM-II filaments and F-actin rings. Loss of actomyosin-II–mediated radial contractility causes defects in axonal trafficking and stability, leading to degeneration.
Complementary Oligonucleotide Conjugated Multi-Color Carbon Dots for Intracellular Recognition of Biological Events.

By using complementary DNA sequences as surface ligands, we selectively allow two individual diffusing 'dual-color' carbon dots to interact in situ and in vitro. Spontaneous nanoscale oxidation of surface-abundant nitroso-/nitro- functionalities leads to two distinctly colored carbon dots (CD) which are isolated by polarity driven chromatographic separation. Green and red emitting carbon dots were decorated by complementary single stranded DNAs which produce a marked increase in the fluorescence emission of the respective carbon dots. Mutual colloidal interactions are achieved through hybridization of complementary DNA base pairs attached to the respective particles, resulting in quenching of their photoluminescence. The observed post-hybridization quenching is presumably due to a combined effect from an aggregation of CDs post duplex DNA formation and close proximity of multi-colored CDs, having overlapped spectral regions leading to a non-radiative energy transfer process possibly released as heat. This strategy may contribute to the rational design of mutually interacting carbon dots for a better control over the resulting assembly structure for studying different biological phenomenon including molecular cytogenetics. One of the newly synthesized CDs was successfully used to image intracellular location of GAPDH mRNA using event of change in fluorescence intensity (FI) of CDs. This selectivity was introduced by conjugating an oligonucleotide harboring complementary sequence to GAPDH mRNA. FI of this conjugated carbon dot, rCD-GAPDH was also found to decrease in presence of Ca2+ and varied in relation to H+ concentrations and could serve as a tool to quantify the intracellular concentrations of Ca2+ and pH value (H+) which can give important information about cell survival. Therefore, CD-oligonucleotide conjugates could serve as efficient probes for cellular events and interventions.
Acute Coronary Syndromes in Chronic Kidney Disease: Clinical and Therapeutic Characteristics

Background and Objectives: This study evaluated the clinical characteristics of the acute coronary syndromes (ACS) in chronic kidney disease (CKD) patients and established prognostic values of the biomarkers and echocardiography. Materials and Methods: 273 patients admitted to the cardiology department of the Clinical County Emergency Hospital of Oradea, Romania, with ACS diagnosis were studied. Two study groups were formed according to the presence of CKD (137 patients with ACS + CKD and 136 with ACS without CKD). Kidney Disease: Improving Global Outcomes (KDIGO) threshold was used to assess the stages of CKD. Results: Data regarding the medical history, laboratory findings, biomarkers, echocardiography, and coronary angiography were analysed for both groups. ACS parameters were represented by ST-segment elevation myocardial infarction (STEMI), which revealed a greater incidence in subjects without CKD (43.88%); non-ST-segment elevation myocardial infarction (NSTEMI), characteristic for the CKD group (28.47%, with statistically significance p = 0.04); unstable angina and myocardial infarction with nonobstructive coronary arteries (MINOCA). Diabetes mellitus, chronic heart failure, previous stroke, and chronic coronary syndrome were more prevalent in the ACS + CKD group (56.93%, p < 0.01; 41.61%, p < 0.01; 18.25%, p < 0.01; 45.26%, p < 0.01). N-terminal pro b-type natriuretic peptide (NT-proBNP) was statistically higher (p < 0.01) in patients with CKD; Killip class 3 was evidenced more frequently in the same group (p < 0.01). Single-vessel coronary artery disease (CAD) was statistically more frequent in the ACS without CKD group (29.41%, p < 0.01) and three-vessel CAD or left main coronary artery disease (LMCA) were found more often in the ACS + CKD group (27.01%, 14.6%). Conclusions: Extension of the CAD in CKD subjects revealed an increased prevalence of the proximal CAD, and the involvement of various coronary arteries is characteristic in these patients. Biomarkers and echocardiographic elements can outline the evolution and outcomes of ACS in CKD patients.