Miracle-dz/UniFAR-FTUs huggingface dataset:
The Combined Treatment With the FLT3-Inhibitor AC220 and the Complex I Inhibitor IACS-010759 Synergistically Depletes Wt- and FLT3-Mutated Acute Myeloid Leukemia Cells

Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with a high mortality rate and relapse risk. Although progress on the genetic and molecular understanding of this disease has been made, the standard of care has changed minimally for the past 40 years and the five-year survival rate remains poor, warranting new treatment strategies. Here, we applied a two-step screening platform consisting of a primary cell viability screening and a secondary metabolomics-based phenotypic screening to find synergistic drug combinations to treat AML. A novel synergy between the oxidative phosphorylation inhibitor IACS-010759 and the FMS-like tyrosine kinase 3 (FLT3) inhibitor AC220 (quizartinib) was discovered in AML and then validated by ATP bioluminescence and apoptosis assays. In-depth stable isotope tracer metabolic flux analysis revealed that IACS-010759 and AC220 synergistically reduced glucose and glutamine enrichment in glycolysis and the TCA cycle, leading to impaired energy production and de novo nucleotide biosynthesis. In summary, we identified a novel drug combination, AC220 and IACS-010759, which synergistically inhibits cell growth in AML cells due to a major disruption of cell metabolism, regardless of FLT3 mutation status.
Socool: A 300 K-0.3 K pulse tube/sorption cooler

CEA/SBT has acquired substantial experience in the fields of Pulse Tube (PTC) and Sorption coolers. Double stage PTC capable of lifting about 0.5 W of cooling power at 4 K have been successfully experimented in the past years. Single stage 3He and 4He sorption coolers have been developed for both ground and space applications. A precooling temperature below 2.5 K is required to operate a 3He sorption cooler efficiently. This is commonly achieved with a pumped liquid 4He bath. However for some applications (for example bolometers cooling in astrophysics) the vibrations induced by the pumping system are problematic. In addition the fraction of liquid lost during the bath pumped down significantly affects the bath hold time. To overcome this difficulty, a double stage (4He/3He) sorption cooler has been developed which can be operated either from an atmospheric 4He bath or from a 4 K PTC, and which provides temperature down to 260 mK. The first experimental results obtained with this cooler and a 4 K PTC deve.
Electrochemical Studies of Green Corrosion Inhibitors

Corrosion of macro to micro-structures has been one of the major causes of structural failure in modern era. Their early detection could assist in limiting their repairs and reducing the associated cost as well. This chapter focusses on the state-of-the-art and development made with green corrosion inhibitors for preventing corrosion. It mainly includes the most recent progress in electrochemical corrosion monitoring techniques for various green inhibitors namely polarization technique, electrochemical impedance spectroscopy, electrochemical noise measurement and electrochemical quartz crystal microbalance techniques. Finally, we conclude with the current progress, limitations and remedies in the recent trends and advancement of green corrosion inhibitors for corrosion prevention.
Compositional characteristics and Ta-Sn-Nb rare metal mineralization potential of Egbe Pegmatite, Southwestern Nigeria

Pan African (600 ± 150) pegmatite which intrudes gneisses, amphibolites, quartzite and schists around Egbe area were studied for their compositional features. This is with a view to characterizing and assessing their potential for rare metal Ta-Sn-Nb mineralization. Twenty seven samples comprising eleven (11) whole rock, sixteen (12) muscovite extracts and four (4) feldspar extracts samples were analyzed using the Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-AES). Major oxide geochemical assessment of the whole rock pegmatite indicates that the pegmatite is siliceous (79.82% SiO2) and moderately high in Al2O3 (12.22%). The K2O, Na2O contents are averagely 2.25% and 2.87% respectively while Fe2O3, MnO, MgO are each less than 1.0%. Average values of trace elements in the pegmatite are Ta (52.55ppm), Sn (92.3 ppm), Rb (1083.5ppm), Nb (109.35 ppm), Cs (32.12ppm), Sr (17.84 ppm), Y (9.86 ppm), and Zr (41.27 ppm), Ba (50.47ppm), Hf (12.38ppm), Zr (41.27ppm), Ga (32.12ppm) and W(2.91PPM) and ratios of diagnostic elements are K/Rb (30.27), Rb/Sr (298.93), Zr/Hf (7.23), Rb/Cs (65.80), K/Cs (1103.11), Ta/W (41.81), Nb/Ta (55.397) Na/Rb (41.77) and Na/K (92.25) A/CAN >1and Al2O3>CaO+ Na2O+ K2O with enrichment of SiO2, Al2O3, Na2O, K2O and depletion of Fe2O3, MnO2 and MgO suggests that Egbe pegmatite is of peraluminous bulk composition and plots of A/NK vs Al/CNK and Rb vs (Y+Nb) discriminates Egbe pegmatite in the peraluminous LCT (Li, Rb, Cs, Be, Ga, Nb Ta, Sn, Hf, B, P, F) of syncollisional to within plate granitic family. The Ta/W vs Cs plot for the three sample media shows the relationship between increasing Ta/W ratio and elemental fractionation as indicated by Cs. The K/Rb vs Cs and K/Rb vs Rb plots for the three sample media further establishes the rare – metal nature and mineralization potential of Egbe pegmatite. Using the discriminant plots of TaVs Rb, Ta vs Cs . TaVs K/Cs, and Ta Vs (Cs+Rb) where most of the samples of the whole rock pegmatite and mineral extracts plots above the Beus line and about 30% plotting above the Gordinyenko line respectively. Overall geochemical assessment is that Egbe pegmatite is a rare metal, highly fractionated Beryl type with rare metal enrichment trend of Nb>>Sn>>Ta. Keywords: Pegmatite, Peraluminous, Syncollisional, Within-plate, Discriminant, Fractionation, Sample media
A new species of Fulvifomes (Basidiomycota) from China

Fulvifomes submerrillii (Hymenochaetaceae, Basidiomycota) is described from China based on both of morphological evidence and molecular data. The new species is characterized by perennial, pileate basidiocarps, encrusted, smooth pileal surface, 6–7 pores per mm with thick dissepiments, a dimitic hyphal system with interwoven skeletal hyphae, absence of setae or setal hyphae, ventricose cystidioles, and broadly ellipsoid, yellowish brown, thick-walled, smooth basidiospores, 4.7–5 × 3.7–4 μm. Phylogenetic analysis inferred from ITS and nLSU sequences indicates that the new species forms a separate well-supported clade, closely related to F. merrillii. However, F. merrillii has larger pores (4–5 per mm), a subdimitic hyphal structure in context, the contextual skeletal hyphae which regularly arranged and become swollen in KOH, and slightly longer (4.5–6 μm long) basidiospores. Moreover, one new combination (F. rigidus) is revived from synonym under Inonotus rigidus.
Anatomical and Image Analysis of Grain Coloration in Rye

In rye, there is a considerable variety of grain color which is determined by the diversity of compounds localized in different parts of the grain (caryopsis) - pericarp, testa, and aleurone. The localization of anthocyanins and proanthocyanidins was analyzed in 26 rye samples with identified anthocyanin genes, along with the analysis of CIE color coordinates. The Grain Scan program [1] was used to analyze images of individual grains. The localization of anthocyanins and proanthocyanidins was studied on longitudinal and cross sections of grains using light microscopy and MALDI-imaging. The violet-grained samples contain anthocyanins in the pericarp, and the green-grained samples contain anthocyanins in the aleurone layer. The green, violet and yellow-grained rye, with the exception of two anthocyaninless mutants vi3 and vi6, shows the presence of proanthocyanidins in the brown-colored testa. Four main color groups of the rye grains (yellow, green, brown, violet) could be differentiated using the color coordinate h° (hue angle). Interspecies and intraspecies variability for the localization of colored flavonoids in cereal grains is discussed.
Least squares estimator for a class of subdiffusion processes

Abstract In this article, we consider the parameter estimation problem for a class of subdiffusion processes which are characterized by the time-changed Ornstein–Uhlenbeck processes. Least squares method is used to obtain the estimator for the drift coefficient. First, we get the strong consistency, asymptotical normality and asymptotical mixed normality for the estimator on the condition that we can observe the process continuously. After that, weak consistent and asymptotic properties are derived basing on discrete observations when the time-change process is an inverse -stable ( ) subordinator.
Cytokinins affect shoot regeneration and modulate the expression of IPT and CKX genes of in vitro cultured Eleocharis dulcis (Brum.f.) Trin

ABSTRACT The Chinese water chestnut (Eleocharis dulcis (Brum.f.) Trin. ) is conventionally propagated by underground corm with a lower propagation rate. In the present study, we attempted to develop a simple and efficient protocol for in vitro shoot regeneration, corm formation, and the generation of plantlets, on MS medium supplemented with BA, TDZ, NAA, and IAA. Additionally, the effect of BA on the expression of EdIPT and EdCKX genes was determined. The highest number of shoots (10.9) was produced by 0.5 mg/L BA, while that was the 0.1 mg/L TDZ (11.9), followed by the combination of 0.1 mg/L TDZ and 0.5 mg/L IAA (10.6), and shoot produced root spontaneously in these treatments. 60 g/L of sucrose was optimal for inducing the shoots while the highest corm number (5.8) was achieved by 90 g/L sucrose. 1.0 mg/L BA was optimal for corm formation with the highest number of corm (3.5) and the largest diameter (7.4 mm). NAA or IAA at 0.1 mg/L was optimal for rooting. Furthermore, we found the expression of EdIPT gene was up-regulated by the application of BA at a relatively lower level, and a high concentration of BA promoted expression of EdCKX gene.
Hydrodynamic quantum field theory: the free particle

We revisit de Broglie’s double-solution pilot-wave theory in light of insights gained from the hydrodynamic pilot-wave system discovered by Couder and Fort [1]. de Broglie proposed that quantum particles are characterized by an internal oscillation at the Compton frequency, at which rest mass energy is exchanged with field energy. He further proposed that the resulting pilot-wave field satisfies the Klein–Gordon equation. While he developed a guidance equation for the particle, he did not specify how the particle generates the wave. Informed by the hydrodynamic pilot-wave system, we explore a variant of de Broglie’s mechanics in which the form of the Compton-scale dynamic interaction between particle and pilot wave is specified. The particle is modeled as a localized periodic disturbance of the Klein–Gordon field at twice the Compton frequency. We simulate the evolution of the particle position by assuming that the particle is propelled by the local gradient of its pilot wave field. Resonance is achieved between the particle and its pilot wave, leading to self-excited motion of the particle. The particle locks into quasi-steady motion characterized by a mean momentum p̄ =ħk, where k is the wavenumber of the surrounding matter waves. Speed modulations along the particle path arise with the de Broglie wavelength and frequency ck. The emergent dynamics is strongly reminiscent of that arising in the hydrodynamic pilot-wave system, on the basis of which we anticipate the emergence of quantum statistics in various settings. Our results suggest the potential value of a new hydrodynamically-inspired pilot-wave theory for the motion of quantum particles.
Regal electrochemistry: sensing of the synthetic cathinone class of new psychoactive substances (NPSs)

In this paper the concept of ‘Regal Electrochemistry’ is expanded towards the electrochemical sensing of Novel Psychoactive Substances (NPSs) namely synthetic cathinone derivatives where British coinage is used as the electrochemical sensor. In this proof-of-concept approach, the electrochemical sensing of mephedrone (4-MMC) and 4′-methyl-N-ethylcathinone (4-MEC) is shown to be possible using a British 1 pence coin for the first time. This novel electrochemical protocol is validated towards the detection of cathinone derivatives in a seized street sample that has been independently analysed via high performance liquid chromatography demonstrating its potential use as a novel electrochemical sensor for NPSs.
A context-driven pansharpening method using superpixel based texture analysis

ABSTRACT In this paper, we propose a context-driven injection scheme for pansharpening, in which the injection coefficients are computed over superpixel segments obtained by means of a modified Simple Linear Iterative Clustering (t-SLIC) technique applied on the texture descriptors of the PAN image. By using the t-SLIC algorithm, various homogeneous-connected components can be generated according to their spectral properties. The proposed pansharpening method relies on a multiresolution framework by employing the Generalized Laplacian Pyramid (GLP) tailored to the Modulation Transfer Function (MTF) of the MS sensors for extracting the high frequency details. First, the injection gains are locally computed as regression coefficients between the upsampled MS and low-resolution PAN regions at a reduced scale. Then, they are multiplied by a global weighting factor computed per spectral band and defined as the ratio of variance between expanded MS bands and PAN image. Finally, the spatial details are modulated by means of the estimated global-local injection coefficients at superpixel level to produce the high-resolution MS image. The validation is assessed with two datasets acquired by IKONOS and WorldView-3 satellites. The experimental results show that the proposed method achieves a favourable performance both visually and quantitatively compared to the state of-the-art pansharpening algorithms.
Characterization of Cr Poisoning in a Solid Oxide Fuel Cell Cathode Using a High Energy X-ray Microbeam

A key feature of planar solid oxide fuel cells (SOFCs) is the feasibility of using metallic interconnects made of high temperature ferritic stainless steels, which reduce system cost while providing excellent electric conductivity. Such interconnects, however, contain high levels of chromium, which has been found to be associated with SOFC cathode performance degradation at SOFC operating temperatures; a phenomenon known as Cr poisoning. Here, we demonstrate an accurate measurement of the phase and concentration distributions of Cr species in a degraded SOFC, as well as related properties including deviatoric strain, integrated porosity, and lattice parameter variation, using high energy microbeam X-ray diffraction and radiography. We unambiguously identify (MnCr){sub 3}O{sub 4} and Cr{sub 2}O{sub 3} as the two main contaminant phases and find that their concentrations correlate strongly with the cathode layer composition. Cr{sub 2}O{sub 3} deposition within the active cathode region reduces porosity and produces compressive residual strains, which hinders the reactant gas percolation and can cause structural breakdown of the SOFC cathode. The information obtained through this study can be used to better understand the Cr-poisoning mechanism and improve SOFC design.
EVALUATION OF POTASSIUM CHLORIDE ADMINISTERED VIA THREE ROUTES FOR EUTHANASIA OF ANESTHETIZED KOI ( CYPRINUS CARPIO )

Abstract: Immersion in tricaine methanesulfonate (MS-222) is insufficient for euthanasia in at least one species of fish. The current study investigated the effectiveness of potassium chloride (KCl) to euthanize anesthetized koi (Cyprinus carpio). Twenty-eight healthy koi were anesthetized via immersion in 500 mg/L of buffered MS-222 for 10–12 min, manually removed to room air, and randomly administered 10 mEq/kg KCl (333 mg/ml) via one of three routes—intracardiac injection (IC) (n = 7), intracoelomic injection (ICe) (n = 7), or topical instillment over the gill filaments bilaterally (T) (n = 7)—or received no treatment (control, C) (n = 7). A Doppler ultrasonic flow detector was placed over the heart, and sounds were assessed continuously from immediately prior to treatment until 5 min posttreatment and every 5 min thereafter until Doppler sound cessation, resumption of operculation, or 30 min. Time to Doppler sound cessation or resumption of operculation was recorded. Doppler sound cessation occurred in 7/7 fish in IC (median 0.08, range 0–2.75 min) and 1/7 fish in T (10 min). In T, ICe, and C, 6/7, 7/7, and 7/7 fish, respectively, maintained Doppler sounds to 30 min. All fish in ICe (7/7) and C (7/7) resumed operculation with median (range) times of 22 (7–30) min and 16 (9–29) min from treatment, respectively. Intracardiac KCl at 10 mEq/kg rapidly ceases Doppler sounds and is a successful technique for euthanasia of anesthetized koi. Intracoelomic and topical KCl at 10 mEq/kg were not effective for euthanasia of koi.
Determination of Elastic Properties of Beech Plywood by Analytical, Experimental and Numerical Methods

This research article examines the application of various methods to determine the effective elastic properties of beech veneer-wood composites. Using laminate theory, the theoretically calculated effective values of the in-plane and out-of-plane modulus of elasticity as well as shear modulus are compared with the values determined from the natural frequencies of flexural, torsional and longitudinal vibrations of samples having different orientations and numbers of composite layers. The samples are also modelled using the finite element method, and their natural frequencies are calculated by the modal analysis. Research has shown that the laminate theory, which is well established and applied in the world of synthetic composites, can also be applied to beech plywood composites, where the theoretically calculated effective values can be up to 15% higher. Similarly, due to the higher calculated effective elastic properties, higher natural frequencies of flexural, torsional and longitudinal vibrations are also calculated by the finite element method.
Video Summarization Techniques: A Review

: With the advancement of technology, the enormous amount of video data is generated on the daily basis. The processing of such huge chunky videos requires high storage, high computational processing power, and consumes a lot of time. Extraction of features from the video is a time-consuming task because the user has to watch the entire video. A large number of editing tools exist that require expertise that is highly expensive. The video summarization is used to overcome these issues that deal with lengthy videos and condense those, based on the various features. This paper presents a review and comparative analysis of video summarization techniques. Initially, these methods have been classified into different categories based on their characteristics. After that, the discussion is made related to the domain directions, applications, pros/cons, and challenges for existing video summarization approaches.
The Rubber Pricing Model: Theory and Evidence

This research explores the appropriate rubber pricing model and the consistent empirical evidence. This model has been derived from the utility function and firm profit-maximization model of commodity goods. The finding shows that the period t – 1 affects expected commodity price and expected profit of commodity production. In fact, a change in the world price of rubber in the past period led to a change in the expected price of rubber in the short run which influenced the expected rubber profit. As a result, the past-period free on board price has an entirety effect on expected farm price of rubber given an exchange rate. In addition, the rubber pricing model indicates that the profit of local farmer on rubber plant depends solely on the world price of rubber in the short run in case of Thailand. In an empirical study, it was found that a change in the price of ribbed smoke sheet 3 in Singapore Commodity Exchange significantly and positively determined the fluctuation of rubber price at the farm gate in Thailand which was consistent with the behavior of the Thai farmers. Both prices are also cointegrated in the long run. That is, the result states that the VECM is an appropriated pricing model for forecasting the farm price in
MiR-193-3p attenuates the vascular remodeling in pulmonary arterial hypertension by targeting PAK4

Pulmonary arterial hypertension (PAH) is a progressive pulmonary vascular disease associated with dysfunction of pulmonary artery endothelial cells and pulmonary artery smooth muscle cells (PASMCs). To explore the potential mechanism of miR-193-3p in pulmonary arterial hypertension, human PASMCs and rats were respectively stimulated by hypoxia and monocrotaline to establish PAH model in vivo and in vitro. The expressions of miR-193-3p and p21-activated protein kinase 4 (PAK4) in the lung samples of PAH patients and paired healthy samples from the healthy subjects in PHA cells and rats were detected by quantitative reverse transcriptase-PCR. Morphological changes in lung tissues were determined using hematoxylin and eosin staining. Right ventricular systolic pressure (RVSP) and ratio of right ventricle to left ventricle plus septum (RV/LV p S) were measured. The binding relationship between miR-193-3p and PAK4 was analyzed by TargetScan and verified by luciferase reporter assay. Cell viability, apoptosis, and migration were detected by 3-(4, 5-Dimethylthiazol-2- yl)-2,5-diphenyltetrazolium bromide (MTT) flow cytometry, and wound-healing assays, respectively. The protein expressions of PAK4, proliferating cell nuclear antigen (PCNA), P21, p-AKT, and AKT in vivo or in vitro were determined by Western blot. In this study, we found that in pulmonary arterial hypertension, miR-193-3p expression was downregulated and PAK4 expression was up-regulated. MiR-193-3p directly targeted PAK4 and negatively regulated its expression. Hypoxia condition promoted cell proliferation, migration, and inhibited apoptosis accompanied with increased expressions of PCNA and p-AKT/AKT and decreased expression of P21 in PASMCs. MiR-193-3p overexpression attenuated the effects of hypoxia on PASMCs via downregulating PAK4. Monocrotaline treatment increased p-AKT/AKT and decreased P21 expression and caused pulmonary vascular remodeling in the model rats. MiR-193-3p overexpression attenuated pulmonary vascular remodeling, decreased p-AKT/AKT, and increased P21 levels via downregulating PAK4 in monocrotaline-induced rats. The results in this study demonstrated that upregulation of miR-193-3p reduced cell proliferation, migration, and apoptosis of PAH in vitro and pulmonary vascular remodeling in PAH in vivo through downregulating PAK4.