Miracle-dz/UniFAR-FTUs huggingface dataset:
MOLLUSCICIDAL AND ANTIFEEDANT IMPACTS OF SOME WEED EXTRACTS ON THE LAND SNAIL MONACHA OBSTRUCTA (PFEIFFER)

The molluscicidal and antifeedant activity of three weeds extracts namely primpernel (Anagallis arvensis L.) (Primulaceae), nightshade (Solanum nigrum L.) (Solanaceae) and nutsedge (Cyperus longus L.) (Cyperaceae) were evaluated against the adult stage of Monacha obstructa (Pfeiffer, 1842) under laboratory conditions. Three methods of bioassay were used i.e. bait, residual film (contact) and antifeeding techniques. The results indicated that chloroform and hexane extracts of primpernel appeared highly toxic when applied as baits on M. obstructa adults while nutsedge was found to be lower toxicity based on LC50 values. Also, chloroform extract of nightshade and hexane extract of primpernel were the most potent with contact whereas nutsedge was the least effective. On the other hand, of either chloroform or hexane extract primpernel tended to be more effective as antifeedant compound than nightshade. In contrast, nutsedge chloroform extract revealed no action as a feeding deterrent whereas the same hexane extract was effective based on SC50 levels. Moreover, fifteen compounds were identified by GC/MS analysis in the chloroform extract of primpernel. Palmatic acid methyl ester (fatty acid) was the dominant compound representing 25.8% followed by aromadendrene (sesquiterpene) forming 15.2% and 2 – tertbutyl 4isopropyl – 5methylphenol (phenolic compound) having 13.9%. In addition to the presence of two steroids, two dicarboxylic acids and only one ketone compound was identified. Finally, the salt of carbamic acid (ammonium carbamate) and the ester of phosphoric acid (tributyl phosphate) were also detected. This study reveals that chemical compounds present in chloroform extract of primpernel has effective source as a molluscicide extracted of plant origin and has potential beneficial control against M. obstructa snails.
Transfer Learning with Real-World Nonverbal Vocalizations from Minimally Speaking Individuals

We trained and evaluated several types of transfer learning to classify affect and communication intent of nonverbal vocalizations from eight minimally speaking individuals (mv*). Datasets were recorded in the real-world with in-the-moment labels from a close family member. We trained deep neural nets (DNNs) on six audio datasets (including our dataset of nonverbal vocalizations) and then ﬁne-tuned the models to classify affect and intent for each individual. We also evaluated a zero-shot approach for arousal and valence regression using an acted dataset of nonverbal vo-calizations that occur amidst typical speech. For two of the eight mv* communicators, ﬁne-tuning improved model performance compared to fully personalized DNNs and there were weak groupings in arousal values inferred using zero-shot learning. The limited success of the evaluated transfer learning approaches highlights the need for specialized datasets with mv* individuals.
NDT_A_286710 1825..1838

1Buenos Aires University, Psychology School, Psychology School Research Institute National Council for Scientific and Technical Research (CONICET), Buenos Aires, Argentina; 2Buenos Aires University, Ramos Mejía Hospital, Epilepsy Center, Buenos Aires, Argentina; 3Buenos Aires University, Medicine School, Cell Biology and Neuroscience Institute (IBCN)National Council for Scientific and Technical Research (CONICET), Buenos Aires, Argentina Abstract: Psychogenic nonepileptic seizures (PNES) are paroxystic and episodic events associated with motor, sensory, mental or autonomic manifestations, which resemble epileptic seizures (ES), but are not caused by epileptogenic activity. PNES affect between 20% and 30% of patients attending at epilepsy centers and constitute a serious mental health problem. PNES are often underdiagnosed, undertreated and mistaken with epilepsy. PNES are diagnosed after medical causes (epilepsy, syncope, stroke, etc.) have been ruled out, and psychological mechanisms are involved in their genesis and perpetuation. For psychiatry, there is not a single definition for PNES; the DSM-IV and ICD-10/11 describe the conversion and dissociative disorders, and the DSM-5 describes the functional neurological disorders. However, patients with PNES also have a high frequency of other comorbidities like depression, particularly trauma and post-traumatic stress disorder. It has been postulated that PNES are essentially dissociations that operate as a defensive psychological mechanism that use the mind as a defense to deal with traumas. With the advent of VEEG in the 90s, the recognition of PNES has significantly increased, and several psychological treatments have been developed. In this manuscript, we carried out a state-of-the-art review, with the aim to provide a critical approach to the extensive literature about PNES, focusing on diagnostic aspects, the primary management, and the available treatments that have been shown to be effective for the improvement of PNES.
Spatiotemporal heterogeneity of b values revealed by a data-driven approach for the 17 June 2019 MS 6.0 Changning earthquake sequence, Sichuan, China

Abstract. The spatiotemporal heterogeneity of b values has great potential for helping in understanding the seismogenic process and assessing seismic hazard. However, there is still much controversy about whether it exists or not, and an important reason is that the choice of subjective parameters has eroded the foundations of much research. To overcome this problem, we used a recently developed non-parametric method based on a data-driven concept to calculate b values. The major steps of this method include (1) performing a large number of Voronoi tessellations and Bayesian information criterion (BIC) value calculation, selecting the optimal models for the study area, and (2) using the ensemble median (Q2) and median absolute deviation (MAD) value to represent the final b value and its uncertainty. We investigated spatiotemporal variations in b values before and after the 2019 Changning MS=6.0 earthquake in the Sichuan Basin, China. The results reveal a spatial volume with low pre-mainshock b values near the mainshock source region, and its size corresponds roughly with the rupture area of the mainshock. The anomalously high pre-mainshock b values distributed in the NW direction of the epicenter were interpreted to be related to fluid invasion. The decreases in b values during the aftershock sequence along with the occurrences of several strong aftershocks imply that b values could be an indicator of the stress state. In addition, we found that although the distribution characteristics of b values obtained from different methods of investigation are qualitatively consistent, they differ significantly in terms of their specific values, suggesting that the best way to study the heterogeneous pattern of b values is in the joint dimension of space-time rather than separately in time and space. Overall, our study emphasizes the importance of b-value studies in assessing earthquake hazards.
In-vitro trypanocidal activity of ethanolic and aqueous extracts of Terminalia catappa leaf

Trypanosomiasis is a globally occurring parasitic disease in animals and humans. Therefore, a herbal therapeutic agent with trypanocidal properties has become increasingly demanded. In this research, the ethanolic and aqueous extracts of Terminalia catappa leaf were tested for their in vitro trypanocidal activity. A total of 40 µl of blood containing about 20-25 Trypanosoma brucei brucei parasites per field was mixed with 20 µl of either ethanolic or aqueous extract solutions containing 100, 80, and 60 mg/ml, respectively, to produce adequate test concentrations of 25, 20, and 15 mg/ml. Ethanolic extract and aqueous extract were tested in vitro for phytochemical composition, antioxidant activity, and anti-trypanosomal activity against at three concentrations (25, 20, and 15 mg per ml) compared to a positive control of diminazene diaceturate and a negative control of glucose phosphate-buffered saline. The positive control and the 25 mg/ml ethanolic extract treatment groups had a complete seizure of Trypanosome motility after 30 minutes. The 20 mg/ml ethanolic extract-treated group had a complete seizure of Trypanosome motility after 45 minutes. A total seizure of Trypanosome motility was observed at 60 minutes with 15 mg/ml ethanolic extract and 25 mg/ml aqueous extract. In conclusion, 25 mg/ml ethanolic extract resulted in an anti-trypanosomal activity in vitro similar to that of the commercialtrypanocidal agent. These results are encouraging to test the viability of this treatment in vivo.
OTT_A_253772 6859..6871

*These authors contributed equally to this work Abstract: Radiotherapy (RT) is a mainstay of cancer treatment. Recent studies have shown that RT not only directly induces cell death but also has late and sustained immune effects. High mobility group box 1 (HMGB1) is a nuclear protein released during RT, with locationdependent functions. It is essential for normal cellular function but also regulates the proliferation and migration of tumor cells by binding to high-affinity receptors. In this review, we summarize recent evidence on the functions of HMGB1 in RT according to the position, intracellular HMGB1 and extracellular HMGB1. Intracellular HMGB1 induces radiation tolerance in tumor cells by promoting DNA damage repair and autophagy. Extracellular HMGB1 plays a more intricate role in radiation-related immune responses, wherein it not only stimulates the anti-tumor immune response by facilitating the recognition of dying tumor cells but is also involved in maintaining immunosuppression. Factors that potentially affect the role of HMGB1 in RT-induced cytotoxicity have also been discussed in the context of possible therapeutic applications, which helps to develop effective and targeted radio-sensitization therapies.
COMPARATIVE STUDY OF CMOS FRACTIONAL-N SYNTHESIZER BASED ON PHASE LOCKED LOOP- A REVIEW

— In the area of communication and wireless system PLL plays an important role for the frequency synthesizers. CMOS fractional-N synthesizer that mainly depend on PLL (phase looked loop). PLL has various application in many areas such as in frequency synthesizer, phase modulation and demodulation, frequency modulation and demodulation, data and clock recovery circuit as well as in tacking filters. The stability and the tuning range of these synthesizers mainly based on PLL. Comparison on different type of frequency synthesizers such as fractional–N synthesizer are presented and different type of parameters for the fractional-N synthesizers such as spur, power dissipation, loop bandwidth, switching speed, lock in range and phase noise are defined for the fractional-N synthesizer.
Can't we all just get along? Citizen scientists interacting with algorithms

Responding to the continued and accelerating rise of Machine Learning (ML) in citizen science, we organized a discussion panel at the 3rd European Citizen Science 2020 Conference to initiate a dialogue on how citizen scientists interact and collaborate with algorithms. This brief summarizes a presentation about two Zooniverse projects which illustrated the impact that new developments in ML are having on citizen science projects which involve visual inspection of large datasets. We also share the results of a poll to elicit opinions and ideas from the audience on two statements, one positive and one critical of using ML in CS. The discussion with the participants raised several issues that we grouped into four main themes: a) democracy and participation; b) skill-biased technological change; c) data ownership vs public domain/digital commons, and d) transparency. All these issues warrant further research for those who are concerned about ML in citizen science.
Accessing Alkyl- and Alkenylcyclopentanes from Cr-Catalyzed Ethylene Oligomerization Using 2-Phosphinophosphinine Ligands

Desilylation of the 2-phosphinophosphinine 2-PPh2-3-Me-6-SiMe3-PC5H2 with HCl gave 2-PPh2-3-Me-PC5H3, demonstrating the late-stage modification of this bidentate heterocyclic ligand. Group 6 metal carbonyl complexes of these ligands showed κ2 binding and very small bite angles of 65.1–68.3°, and also demonstrated that the donor properties of 2-phosphinophosphinines can be tuned readily by the presence of the SiMe3 group, which gives a more π accepting phosphinine ligand. The properties of 2-phosphinophosphinines were compared to those of bidentate diphosphorus ligands computationally, contextualizing them in the ligand knowledge base for bidentate P,P donor ligands (LKB-PP), and were found to occupy an area of ligand space adjacent to Ar2PN(R)NAr2 ligands that have been successfully used in ethylene oligomerization reactions, but with well-separated properties in the second principal component. Testing 2-phosphinophosphinines in Cr-catalyzed ethylene oligomerization reactions showed key differences from s.
Epidemiological Relation between Public Health Hazards and Nutritional Status of Primary School Children in Bankura District, West Bengal

The health and nutritional status of schoolchildren is an index of national investment in the development of their future workforce. Malnutrition affects the child's physical and cognitive growth and increases susceptibility to infection, while indirectly affecting the country's economic growth. The school age group (518 years) covers the period between pre-school age and adult life. In India, almost a third of the population is a school-age child. The age of primary school is a dynamic phase of physical growth and mental development of the child. Studies show that nutritional deficiencies and poor health among primary school children are among the causes of low enrollment rates, high absenteeism, early school leaving and poor classroom performance. The current position regarding the health and nutritional status of children in our country is very unsatisfactory.
Design of Composites by Infiltration Process: A Case Study of Liquid Ir-Si Alloy/SiC Systems

The design of processing routes involving the presence of the liquid phase is mainly associated with the knowledge of its surface and transport properties. Despite this need, due to experimental difficulties related to high temperature measurements of metallic melts, for many alloy systems neither thermodynamic nor thermophysical properties data are available. A good example of a system lacking these datasets is the Ir-Si system, although over the last fifty years, the structures and properties of its solid phases have been widely investigated. To compensate the missing data, the Gibbs free energy of mixing of the Ir-Si liquid phase was calculated combining the model predicted values for the enthalpy and entropy of mixing using Miedema’s model and the free volume theory, respectively. Subsequently, in the framework of statistical mechanics and thermodynamics, the surface properties were calculated using the quasi-chemical approximation (QCA) for the regular solution, while to obtain the viscosity, the Moelwyn-Hughes (MH) and Terzieff models were applied. Subsequently, the predicted values of the abovementioned thermophysical properties were used to model the non-reactive infiltration isotherm of Ir-Si (eutectic)/SiC system.
A SIAN J OURNAL OF C HEMISTRY A SIAN J OURNAL OF C HEMISTRY RP-HPLC Method for Estimation of Ado-Trastuzumabe Emtansine Injection in Pharmaceutical Dosage Form

The aim of the present work is to develop and validate a simple, reliable and accurate method for ado-trastuzumab emtansine in pharmaceutical dosage form by reverse phase HPLC method. The proposed RP-HPLC (reverse phase-high performance liquid chromatography) method utilized a WATERS HPLC (model-Agilent 2695), C18 RP Column (150 mm × 4.6 mm × 5 µm) in separation mode with mobile phase consisting of 0.1 M potassium dihydrogen phosphate (KH 2 PO 4 ) and methanol in the ratio of 55: 45 % (v/v), at a flow rate 1.1 mL/ min and the effluent was monitored at 242 nm. The retention time of ado-trastuzumabe emtansine was 3.2 min. The method was linear in range of 50 to 150 µg and the correlation coefficient was 0.999. The percentage recovery was 100 %. LOD (limit of detection) and LOQ (limit of quantitation) for this method were found to be 0.236 and 0.787, respectively. The present method is very simple, sensitive and accurate procedure for estimation of ado-trastuzumabe emtansine.
The Role of Agile Teams in the Delivery of Distance Education in Saudi Universities Amid the COVID-19 Crisis: Qualitative Data Analysis

The objective of this study is to investigate the role of agile teams in the service delivery of Saudi higher education amid the COVID-19 crisis. The qualitative design of this study allows for an open-ended data collection instrument defined by a semi-structured interview process and thematic data analysis. The study employs a purposive strategy to sampling whereby direct engagements are administered between the author and individual participants. The study therefore analyzes data inductively and reports results where codes are defined, patterns are identified, and themes are generated. The first theme is that the future of Saudi higher education is learner-focused. The second theme is that the value of agile teams increases in the level of operational complexity of distance education. The third theme is that the COVID-19 crisis has left a permanent impact on the way higher education is delivered. The fourth theme is that the agility features of adaptability and responsiveness are highly desirable in Saudi higher education settings. The fifth and the last theme is the great potential for agile teams in the delivery of distance education to enhance learners’ labor market competitiveness while augmenting their sense of responsible citizenship. The study implies that agile teams have great potential in the service delivery of Saudi higher education.
Title : Identification of a novel FUS / ETV 4 fusion and comparative analysis with 1 other Ewing sarcoma fusion proteins

51 Ewing sarcoma is a pediatric bone cancer defined by a chromosomal translocation fusing one of 52 the FET family members to an ETS transcription factor. There have been seven reported 53 chromosomal translocations, with the most recent reported over a decade ago. We now report a 54 novel FET/ETS translocation involving FUS and ETV4 detected in a Ewing sarcoma patient. 55 Here, we characterized FUS/ETV4 by performing genomic localization and transcriptional 56 regulatory studies on numerous FET/ETS fusions in a Ewing sarcoma cellular model. Through 57 this comparative analysis, we demonstrate significant similarities across these fusions, and in 58 doing so, validate FUS/ETV4 as a bona fide Ewing sarcoma translocation. This study presents 59 the first genomic comparison of Ewing sarcoma-associated translocations and reveals that the 60 FET/ETS fusions share highly similar, but not identical, genomic localization and transcriptional 61 regulation patterns. These data strengthen the notion that FET/ETS fusions are key drivers of, 62 and thus pathognomonic for, Ewing sarcoma. 63 64 Implications 65 Identification and initial characterization of the novel Ewing sarcoma fusion, FUS/ETV4, 66 expands the family of Ewing-fusions and extends the diagnostic possibilities for this aggressive 67 tumor of adolescents and young adults. 68 69 70
Laboratory data on wave propagation through vegetation with following and opposing currents

Abstract. Coastal vegetation has been increasingly recognized as effective buffer against wind waves. Recent studies have advanced our understanding of wave dissipation process in vegetation (WDV). In intertidal environments, waves commonly propagate into vegetation fields with underlying tidal currents, which may alter WDV, but such influence is often overlooked. The key mechanism of WDV with co-existing currents are understudied, as previous studies have drawn contradictory conclusions on the effect of following currents on WDV. Subsequent laboratory experiments have partly explained the inconsistent conclusions, but relevant data are rarely available for theoretical or modelling development. Additionally, while the vegetation drag coefficient is a key factor influencing WDV, it is rarely reported for combined wave-current flows. This paper reports a unique dataset from two flume experiments, including 668 wave-only and wave with following/opposing current tests. A variety of data including wave height, drag coefficient, in-canopy velocity and acting force on mimic vegetation stem are recorded. This dataset is expected to assist future theoretical advancement on WDV, which may ultimately lead to more accurate prediction of wave dissipation capacity of real coastal wetlands. The dataset is available from figshare (https://doi.org/10.6084/m9.figshare.13026530.v2; Hu et al., 2020) with clear instructions for reuse. The current dataset will expand with additional WDV data from ongoing as well as planned future observation in real mangrove wetlands.
Discourse behavior of possessives reflects the importance of interpersonal relationships

Nominal possessive constructions (e.g. Sam’s car) present a challenge for theories of discourse since, unlike simpler nominal phrases (e.g. a car), they explicitly refer to two entities, not just one. Research on the discourse prominence of these two referents has been limited in scope and produced contradictory findings. We use a sentence continuation experiment to investigate the prominence of possessions as a function of their animacy. We find that possessed animates (e.g. her butler) are especially prominent. Their privileged status in discourse may relate to non-linguistic theories on the importance of interpersonal relationships.
State Supervised Steering Function for Sampling-based Kinodynamic Planning

Sampling-based motion planners such as RRT* and BIT*, when applied to kinodynamic motion planning, rely on steering functions to generate time-optimal solutions connecting sampled states. Implementing exact steering functions requires either analytical solutions to the time-optimal control problem, or nonlinear programming (NLP) solvers to solve the boundary value problem given the system's kinodynamic equations. Unfortunately, analytical solutions are unavailable for many real-world domains, and NLP solvers are prohibitively computationally expensive, hence fast and optimal kinodynamic motion planning remains an open problem. We provide a solution to this problem by introducing State Supervised Steering Function (S3F), a novel approach to learn time-optimal steering functions. S3F is able to produce near-optimal solutions to the steering function orders of magnitude faster than its NLP counterpart. Experiments conducted on three challenging robot domains show that RRT* using S3F significantly outperforms state-of-the-art planning approaches on both solution cost and runtime. We further provide a proof of probabilistic completeness of RRT* modified to use S3F.