Miracle-dz/UniFAR-FTUs huggingface dataset:
Paper VII Effects of alkylphenols on glycerophospholipids and cholesterol in liver and brain from female Atlantic cod (Gadus morhua)

Offshore oil production releases large amounts of lipophilic compounds in produced water into the ocean. In 2004, 143 million m produced water, containing approximately 13 tons of long-chain (NC4) alkylphenols (AP), was discharged from installations in the Norwegian sector of the North Sea. Long-chain APs are known to cause endocrine disruption in a number of species. However, relatively little is known about their longterm effects in the marine environment. In the present study, Atlantic cod (Gadus morhua) were exposed (0.02 to 80 mg AP/kg) to a mixture (1:1:1:1) of APs (4-tert-butylphenol, 4-n-pentylphenol, 4-n-hexylphenol and 4-n-heptylphenol) or 17 β-estradiol (5 mg E2/kg) for 5 weeks and the effect on the fatty acid profile and cholesterol content in the membrane lipids from the liver and the brain was studied. We also determined the interaction between different para-substituted APs and glycerophospholipids (native phospholipids extracted from cod liver and brain) and model phosphatidylcholine (PC 16:0/22:6 n-3) in monolayers with the Langmuir–Blodget technique. The study demonstrated that APs and E2 alter the fatty acid profile in the polar lipids (PL) from the liver to contain more saturated fatty acids (SFA) and less n-3 polyunsaturated fatty acids (n-3 PUFA) compared with control. In the brain of the exposed groups a similar effect was demonstrated, although with higher saturation of the fatty acids found in the neutral lipids (mainly cholesterol ester), but not in the polar lipids. The AP and E2 exposure also gave a decline in the cholesterol levels in the brain. The in vitro studies showed that APs increased the mean molecular areas of the PLs in the monolayers at concentrations down to 5 μM, most likely due to intercalation of the APs between PL molecules. The increase in molecular area increased with the length of the alkyl side chain. © 2007 Elsevier Inc. All rights reserved.
Selective attention in children with reading disorders

Objective: This work was designed to assess the selective attention in children with reading disorder (RD) using negative difference wave test (Nd) or processing negativity (PN) and Stroop test.Design: The study included 40 children, divided into two groups; study group (SG) and control group (CG). SG consisted of 20 children with [RD]. CG consists of 20 normal children. All children were submitted to basic audiological evaluation, negative difference (Nd) wave test and Stroop test.Results: The reading disorder (RD) group showed delayed latency and decreased amplitude for both components of Nd. Results of Stroop test were significantly high among children with reading disorder compared with normal control.Conclusion: In children with learning disability, selective attention is affected. Poor selective attention may contribute to poor letter and word recognition.
The prognostic significance of weight loss in chronic obstructive pulmonary disease‐related cachexia: a prospective cohort study

Cachexia is an important extra‐pulmonary manifestation of chronic obstructive pulmonary disease (COPD) presenting as unintentional weight loss and altered body composition. Previous studies have focused on the relative importance of body composition compared with body mass rather than the relative importance of dynamic compared with static measures. We aimed to determine the prevalence of cachexia and pre‐cachexia phenotypes in COPD and examine the associations between cachexia and its component features with all‐cause mortality.
Inhibition of Pathogen Adhesion by Bacterial Outer Membrane-Coated Nanoparticles.

The treatment of bacterial infection is increasingly challenged by the rapid emergence of antibiotic resistance. Among various alternatives, anti-adhesion therapies that interfere with the bacterial adhesion to the host are attractive, as they avoid direct disruption of bacterial cycles for killing and thus may alleviate resistance development. Herein, an anti-adhesion nanomedicine platform is made by wrapping synthetic polymeric cores with bacterial outer membranes. The resulting bacterium-mimicking nanoparticles (denoted 'OM-NPs') compete with source bacteria for binding to the host, overcome network complexity of bacterial virulence, and ultimately inhibit bacterial adhesion. The 'top-down' fabrication of OM-NPs avoids the identification of the adhesins and bypasses the design of agonists targeting these adhesins. In this study, OM-NPs are made with membrane of Helicobacter pylori (H. pylori) and shown to bind with gastric epithelial cells (e.g., AGS cells). Treatment of AGS cells with OM-NPs reduces H. pylori adhesion and such anti-adhesion efficacy is dependent on OM-NP concentration as well as the dosing sequence in relation to that of H. pylori. In addition, OM-NPs displace H. pylori pre-bound to AGS monolayers. In a mouse stomach model, OM-NPs reduce H. pylori adherence. These results together demonstrate that OM-NP confer an anti-adhesion property with potential as an anti-adhesion approach against bacterial infections.
PHARMACOLOGICAL EVALUATION OF DAZZLE COOL CREAM FOR ANTI - INFLAMMATORY A ND ANALGESIC ACTIVITY

Musculoskeletal injuries are most common risk factors for sport person s . Pain and swelling are the most common associ ated symptoms of such injuries. A use of non - steroidal anti - inflammatory drugs (NSAIDs) has been routine in the management of musculoskeletal inflammation and pain. Although effective at reducing pain and inflammation, NSAIDs may not be appropriate to use frequently or long er time due to their known side effect s . H erbal and Ayurvedic products are widely perceived as safe d ue to their natural origin and long historical clinical use . Hence in the present study , Dazzle Cool Cream – An Ayurvedic proprietary for mulation has been selected for evaluation of its anti - inflammatory and analgesic activity . Anti - inflammatory activity was evaluated by Complete freund’s adjuvant (CFA) induced acute and chronic phase inflammation. Analgesic activity was evaluated by H ot pl ate method and T ail flick method. Total study was performed on 10 groups of animal where e ach group was contain ing 6 animals . Marketed gel containing Diclofenac diethylamine BP 1.16 % w/w was considered as standard drug for both activities. Paw volume was significantly lowered at 7 th , 14 th and 21 st day in test drug and standard drug group with respect to disease control . Dazzle Cool Cream showed 28.16 % inhibition in paw volume at 21 st day which was comparable to standard marketed gel containing Diclofenac diethylamine BP 1.16 % w/w showing 29.88 % inhibition . Dazzle Cool Cream showed significant effect on inflammatory markers such as ESR, CRP and WBC. It also exhibited significant analgesic activity in both Hot plate and Tail flick nociceptive tests. On the basis of available results, it can be concluded that Dazzle Cool Cream has promising anti - inflammatory and analgesic activity.
Study to Cost of Air Spares Support Based on IPSO

Air spares support is general term of using and repairing of aircrafts which is the material foundation of aero technical support, its effectiveness influences operational effectiveness and equipments of aircrafts directly. Based on particle swarm optimization algorithm, a new model is proposed to optimize the distribution of the cost of air spares, it take the funds as resource and the improvement of performance efficiency as objective and deduces the expressions to get the best distribution plan. The results of experiments indicate that this model can make full use of the limited funds and obtain the highest efficiency of air spares support.
Vessel-length determination using silicone and air injection: Are there artifacts?

Xylem vessels are used by most angiosperm plants for long-distance water and nutrient transport. Vessel length is one of the key functional traits determining plant water-transport efficiency. Additionally, determination of maximum vessel length is necessary for correct sample collection and measurements in hydraulic studies to avoid open-vessel and cutting-under-tension artifacts. Air injection and silicone injection (BLUESIL RTV141A and B mixtures) are two widely used methods for maximum vessel length determination. However, the validity of both methods needs to be carefully tested for species with different vessel lengths. In this study, we tested the air-injection and silicone-injection methods using eight species with different vessel lengths: short (<0.5 m), medium (0.5-1 m), and long (>1 m). We employed a novel approach using RTV141A injection without the RTV141B hardener as a reference method because RTV141A cannot penetrate inter-vessel pit membranes and is not prone to hardening/solidification effects during the injection process. The results revealed that the silicone-injection method substantially underestimated the maximum vessel length of all eight species. However, the air-injection method tended to overestimate the maximum vessel length in five out of eight species. The ratio of underestimation of the silicone-injection method was higher for species with longer vessels, but the overestimation of the air-injection method was independent of the vessel length. Moreover, air injection with different pressures-ranging from 40 to 300 kPa-resulted in comparable results. We conclude that the conventional silicone-injection method can underestimate the vessel length, whereas the air-injection method can overestimate the maximum vessel length, particularly for long-vessel species. We recommend RTV141A-only injection for determining the maximum vessel length, and it can also be used to validate the use of the air-injection and conventional silicone-injection methods for a given species.
Using Authentic Spoken Language Norms in Scripted Role Plays to Teach Register Awareness

This investigate teaching pragmatic competence, specifically the appropriate register. The subjects were 34 2nd year EFL students enrolled in "Basic Conversation", over one semester, at a Japanese national university. Students wrote and performed 4 scripted dialogues as part of an ABAB single case study where the intervention was focusing exercises of optimal features ofthe oral register in authentic NS dialogues. Comparison ofthe baseline and subsequent scripts using the Wllcoxon Signed Ranks Test (non-parametric) showed a significant increase in the use ofspoken features. Student feedback and instructor observation also provided coITOboration. The results point to the utility of authentic materials in the
Endophytic Fungi Isolated from Crocus sativus L. (Saffron) as a Source of Bioactive Secondary Metabolites

Introduction: Endophytic fungi are becoming an important source of new natural bioactive products. Many interesting endophytic fungi have been isolated from traditional medicinal plants. Crocus sativus L. (saffron) is one of the most expensive and rarest spices in the world, used as a dye, aroma and for medicinal purposes. This study reports on the molecular characterization of endophytic fungi isolated from roots of saffron plants growing in TaliouineMorocco, and the examination of the antibacterial and antioxidant activities of secondary metabolites extracted from these endophytes. Methods and Material: The fungi were isolated from sterilized saffron root fragments and identified using internal transcribed spacer (ITS) rRNA gene sequence analysis. Three endophytes were fermented and extracted with ethyl acetate (EtOAc) and chloroform (CHCl3). The antibacterial activity of fungi extracts was evaluated using the Agar Diffusion Method against six strains, Bacillus sp. , Stenotrophomonas sp. , Pseudomonas putida, Pantoea sp. , Luteibacter sp. and Escherichia coli. The antioxidant activity was tested by using the α,α-diphenyl-β-picrylhydrazyl (DPPH) analysis and β-Carotene bleaching test (BCBT) methods. Results: Sixty fungal isolates were recovered and purified from saffron roots. ITS rDNA sequences were 99-100% identical to three different species: Rhizopus oryzae, Aspergillus fumigatiaffinis and Aspergillus niger. Both Rhizopus oryzae extracts had high antibacterial activity against most of the bacteria tested, while Aspergillus niger and Rhizopus oryzae extracts showed an antioxidant capacity using DPPH and BCBT methods, respectively. Conclusion: The fungal endophytes inhabiting saffron roots could be a potential source of natural plant bioactive secondary metabolites especially for antibacterial and antioxidant purposes.
品牌信任受價值知覺與服務品質之影響： 以旅館顧客滿意度為中介;How Brand Trust is Influenced by Perceived Value and Service Quality: Mediated by Hotel Customer Satisfaction

This paper examines the effect of perceived value and service quality on brand trust directly and indirectly through customer satisfaction. Brand trust can be defined as the relationship between consumers and the corporate that is based on trust and reliability of its performance. Questionnaires were given to guests of three-star hotels in Malang, Indonesia, with 158 surveys returned and 114 valid responses were analyzed. Reliability and validity were examined first, and partial least squares (PLS-SEM) analysis was performed to evaluate the determinant coefficient (R 2 ), predictive relevance (Q 2 ), and effect size (f 2 ). Results showed customer satisfaction partially mediates perceived value on brand trust, and fully mediates the relationship between service quality and brand trust. Future research in other developing countries, against different hotel class, with international guests, is recommended. Managerial implications were discussed.
Effect of MgCl2 on energy generation by Reverse Electrodialysis

Effect of MgCl2 on Energy Generation by Reverse Electrodialysis Ahmet H. Avci, Pinkey Sarkar, Diego Messana, Enrica Fontananova, Gianluca Di Profio, Efrem Curcio a Department of Environmental and Chemical Engineering, University of Calabria DIATIC-UNICAL, Via P. Bucci CUBO 45A, 87036 Rende (CS) Italy b Institute on Membrane Technology, National Research Council of Italy ITM-CNR, Via P. Bucci CUBO 17C, 87036 Rende (CS) Italy ahmethalilavci@hotmail.com
Acetaminophen‐induced liver injury is mediated by the ion channel TRPV4

Overdosing of the analgesic acetaminophen (APAP) is one of the most common causes for acute liver failure in modern countries. Although the exact molecular mechanisms mediating hepatocellular necrosis are still elusive, it is preceded by oxidative stress triggered by excessive levels of the metabolite N‐acetyl‐para‐benzoquinone imine (NAPQI). Here, we describe the role of the redox‐sensitive transient receptor potential (TRP) ion channel TRP vanilloid 4 (TRPV4) for APAP‐induced hepatoxicity. Both pharmacological inhibition and genetic deletion of TRPV4 ameliorate APAP‐induced necrosis in mouse and human hepatocytes in vitro. Liver injury caused by a systemic overdose of APAP is reduced in TRPV4‐deficient mice and in wild‐type mice treated with a TRPV4 inhibitor. The reduction of hepatotoxicity accomplished by systemic TRPV4 inhibition is comparable to the protective effects of the antioxidant N‐acetyl‐cysteine. Although TRPV4 does not modulate intrahepatic levels of glutathione, both its inhibition and genetic deletion attenuate APAP‐induced oxidative and nitrosative stress as well as mitochondrial membrane depolarization. NAPQI evokes a calcium influx by activating heterologously expressed TRPV4 channels and endogenous TRPV4 channels in hepatoma cells but not in primary mouse hepatocytes. Taken together, our data suggest that TRPV4 mediates APAP‐induced hepatotoxicity and thus may be a suitable target for treatment of this critical side effect. —Echtermeyer, F. , Eberhardt, M. , Risser, L. , Herzog, C. , Gueler, F. , Khalil, M. , Engel, M. , Vondran, F. , Leffler, A. Acetaminophen‐induced liver injury is mediated by the ion channel TRPV4. FASEB J. 33, 10257–10268 (2019). www.fasebj. org
Unbalanced-to-Balanced Power Divider with Arbitrary Power Division

In this paper, Gysel type Unbalanced-to-Balanced (UTB) Power Divider (PD) with arbitrary power division is proposed. UTB PD is a five-port device, and a standard scattering matrix for a five-port PD with arbitrary power division is derived. Design equations are obtained analytically. Using design equations, a UTB PD is designed at 2GHz for power division ratio of 1 : 2, and simulation is carried out using HFSS. A prototype is fabricated, and measurement is performed to verify the simulation results of PD. Measured results are in good agreement with the simulated ones. The proposed PD shows in-phase characteristic within ±5◦. Measurement results show that isolation between two output ports is greater than 20 dB. Greater than 20 dB common-mode suppression from input port to output balanced ports is achieved. Differential-mode power is divided in power division ratio of 1 : 2 from unbalanced port to balanced ports. Measured fractional bandwidth of the proposed PD is 21%.
PATHOGENESIS AND CONTROL OF MYROTHECIUM SPP., THE CAUSE OF LEAF SPOT ON BITTER GOURD (MOMORDICA CHARANTIA LINN.)

Seed and soil inoculation by M. roridum and M. verrucaria reduced seed germination and caused seed rot, damping off, root rot and spots on aerial parts of bitter gourd. Isolates of M. roridum were found more pathogenic than isolates of M. verrucaria. This is the first report of seedling and root infection of M. roridum and M. verrucaria and also the first report of M. verrucaria leaf spot disease in bitter gourd. Isolates of M. roridum were found more pathogenic than isolates of M. verrucaria. Foliar sprays of fungicides and oil cakes extract significantly reduced the incidence and were found superior to other treatments in controlling disease. Maximum percent efficiency of disease control was observed where Topsin-M was sprayed on M. roridum (87.48%) and M. verrucaria (95.79%) inoculated leaves of bitter gourd.
Comparison Between Genetic and Particle Swarm Optimization Algorithms in Optimizing Ships ’ Degaussing Coil Currents

─ This paper presents a comparison between two well-known evolutionary algorithms in optimization of the degaussing coils currents of a ship which are used to reduce the magnetic anomalies of the ferromagnetic hull of the ships induced by the Earth’s magnetic field. To achieve this, first the magnetic anomalies of a simple model of a ship and the effect of each degaussing coil are simulated by using 3D finite element analysis (FEA) software. Then, both genetic algorithm and particle swarm optimization are used to find the best fitting coil currents which can reduce the anomalies of the ship. Using these algorithms is much simpler than optimizing this problem in FEA software in which a huge amount of numerical analyses are needed. This comparison will show which of these algorithms works better in this specific problem. Index Terms ─ Degaussing system, ferromagnetic material, genetic algorithm, magnetic anomaly, magnetization, particle swarm optimization.
Poly-Gamma-Glutamic Acid Functions as an Effective Lubricant with Antimicrobial Activity in Multipurpose Contact Lens Care Solutions

In order to perform the multiple functions of disinfection, cleansing, and storage, preservatives are often added to contact lens care solutions. The disadvantage of adding preservatives is that this often causes various eye conditions. However, lens care solutions would not be able to disinfect in the absence of such preservatives. In addition, comfort is an important issue for contact lens wearers due to the long periods of time they are worn. It has been shown that lower friction coefficients are correlated with increased comfort. We have previously developed a multipurpose contact lens care solution in which poly-gamma-glutamic acid (γ-PGA) was the main ingredient. In this study, we investigated the antimicrobial activity and lubricating property of our care solution. We showed that there was a synergetic effect of γ-PGA and chlorine dioxide on antimicrobial activity. We also demonstrated that γ-PGA functioned as a lubricating agent. Our results provided evidence of γ-PGA acting as a multi-functional polymer that could be applied in contact lens care solutions.
Prediction of geogrid-reinforced flexible pavement performance using artificial neural network approach

This study aimed to develop a methodology to incorporate geogrid material into the Pavement ME Design software for predicting the geogrid-reinforced flexible pavement performance. A large database of pavement responses and corresponding material and structure properties were generated based on numerous runs of the developed geogrid-reinforced and unreinforced pavement models. The artificial neural network (ANN) models were developed from the generated database to predict the geogrid-reinforced pavement responses. The developed ANN models were sensitive to the change of base and subgrade moduli, and the variation of geogrid sheet stiffness and geogrid location. The ANN model-predicted geogrid-reinforced pavement responses were then used to determine the modified material properties due to geogrid reinforcement. The modified material properties were finally input into the Pavement ME Design software to predict geogrid-reinforced pavement performance. The ANN approach was rapid and efficient to predict geogrid-reinforced pavement performance, which was compatible with the Pavement ME Design software.
Do they practice what we teach? Follow-up evaluation of a Schema Therapy training programme

Abstract This study evaluated a 3-day Schema Therapy (ST) training programme for trainee clinical psychologists. The training used an experiential model of learning, which was intended to encourage the transfer of knowledge and techniques from the learning environment into clinical practice. Using a mixed-methods approach, the training programme was evaluated in terms of: (1) self-reported changes in knowledge, confidence and willingness to use ST-informed techniques; (2) whether the training was integrated into clinical practice; and (3) the perceived barriers/facilitators to achieving practice integration. Participants – 17 of the 19 trainee clinical psychologists enrolled on the ST training programme – completed assessments immediately pre- and post-training. Participants were subsequently followed-up for reassessment 3 months after the training. Group- and individual-level analyses showed that most participants reported training-related gains in knowledge and confidence; these were largely sustained at follow-up, and were associated with post-training practice integration of ST concepts and techniques. Analysis of qualitative data identified factors moderating use of training in practice. Findings of the study have implications for future delivery and evaluation of training in cognitive-behavioural therapies.