Miracle-dz/UniFAR-FTUs huggingface dataset:
METABOLIC CHANGES OF KK MICE WITH AGING 7

25 Research into the prevention and treatment of age-related metabolic diseases are important in the 26 present-day situation of the aging population. We propose that an elderly diabetic mouse model may 27 be useful to such research as it exhibits deterioration of glucose and lipid metabolism. Although the 28 KK mouse strain is commonly used as a model of moderate obesity and type 2 diabetes, the utility of 29 this strain as an elderly obese and diabetic model mouse for research into aging remains unclear. The 30 present study aimed to investigate age-related changes of glucose and lipid metabolism in male KK 31 mice fed a standard chow diet. 32 We demonstrate that 40 weeks KK mice exhibit age-related dysfunctions, such as development of 33 insulin resistance associated with pancreatic islet hypertrophy and decreased lipolysis in white adipose 34 tissue (WAT) compared with 15 weeks KK mice. However, aging does not appear to cause 35 mitochondrial dysfunction of brown adipose tissue. Unexpectedly, hyperglycemia, potential glucose 36 uptake in insulin-sensitive organs, hepatic lipid accumulation, hypertrophy of adipocytes, and 37 inflammation in epididymal WAT did not worsen but rather compensated in 40 weeks KK mice. Our 38 data indicate that the use of male KK mice as an elderly obese and diabetic mouse model has some 39 limitations and in order to represent a useful elderly obese and diabetic animal model, it may be 40 necessary to induce deterioration of glucose and lipid metabolism in KK mice through breeding with 41 high-sucrose or high-fat diets. 42 pathophysiological features of elderly KK mice are comparable with that of aged humans. The present study aimed to provide further basic characterization of elderly KK mice and evaluate the suitability of this strain as an elderly obese and diabetic model mouse for research into aging 75 including glucose and lipid metabolism. We assessed age-related changes in phenotype and gene 76 expression in insulin-response organs of both young and elderly male KK mice relative to C57BL/6J 77 (B6) mice as a lean control under standard laboratory chow-feeding conditions.
THE DANTZIG STATISTICAL ESTIMATION WHEN p IS MUCH LARGER THAN n

given just a single parameter t . Two active-set methods were described in [11], with some concern about efficiency if p were large, where X is n × p . Later when basis pursuit de-noising (BPDN) was introduced [2], the intention was to deal with p very large and to allow X to be a sparse matrix or a fast operator. A primal–dual interior method was used to solve the associated quadratic program, but it remained a challenge to deal with a single parameter. The authors’ new Dantzig Selector (DS) also assumes a specific parameter. It is helpful to state the BPDN and DS models together:
Temporomandibular Joint Disorder from a Perspective of Gerodontology

The final years of the current decade (2000-2010), which were dedicated to bone and joint diseases by the World Health Organization, are the right time to pay attention to musculoskeletal diseases of the orofacial system. A basic concept related to TMDs is the attempt to include musculoskeletal disorders of the stomatognathic system into the functional schematics of disorders appearing elsewhere in the body. Apart from the general knowledge on ageing, undergraduate dental students should be taught about anticipating needs, planning and implementing treatment and the subsequent care of the elderly prosthodontic patients. The clinical picture of TMJ functional disturbances may range from physiological variability of joint structures functioning (sometimes painless joint sound) to painful condition with pronounced clinical signs of TMJ disorder.
Integrating Static Taint Analysis in an Iterative Software Development Life Cycle

—Web applications expose their host systems to the end-user. The nature of this exposure makes all Web applications susceptible to security vulnerabilities in various ways. Two of the top problems are information ﬂow based, namely injection and cross-site scripting. A way to detect information ﬂow based security ﬂaws is by performing static taint analysis. The idea is that variables that can directly or indirectly be modiﬁed by the user are identiﬁed as tainted. If a tainted variable is used to execute a critical command, a potential security ﬂaw is detected. In this paper, we study how to integrate static taint analysis in an iterative and incremental development process to detect information ﬂow based security vulnerabilities.
One Plus One Equals Three: The Synergistic Effects Of Crop Rotation On Soil Fertility And Plant Nutrition

Corn grown under annual corn-soybean crop rotation has greater accumulation of certain mineral nutrients and higher yields than corn grown in monoculture. This study was conducted to determine if complex crop rotations (with legumes in the rotation as alfalfa hay as well as soybean row crops) and different levels of agriculture chemical input affect soil fertility and corn mineral nutrient composition. The effects of crop rotation [monoculture corn, corn-soybean 2-yr rotation, cornsoybean-wheat underseeded with alfalfa-alfalfa 4-yr rotation] and input level [high input (fertilizer application for 8.15 Mg hai yield goal, prophylactic herbicide and insecticide application, fall moldboard plow/spring disk and cultivation operations), intermediate input (fertilizer application for 5.33 Mg haI yield goal, pesticide applications based upon pest survey and IPM principles, fall chisel plow/spring disk and cultivation operations), and low input (no fertilizer, herbicide, or insecticide applications, fall chisel plow/spring disk and cultivation operations)] on soil fertility (pH, organic matter, N03-N, P, K, and total N) and on corn shoot dry weight, mineral nutrient (N, P, Ca, Mg) concentration and accumulation at tassel stage of development were investigated at Brookings, SD. Soil samples taken at the V6 stage of corn development indicated that crop rotation treatments reduced soil pH, increased soil N03-N level, and decreased soil P level when compared to corn monoculture. Shoots of plants grown under either 2-yr rotation intermediate input or 4-yr rotation no input treatments had greater dry weight, as well as greater P, Ca, and Mg accumulation than these same input treatments in other rotations. These results demonstrate a beneficial effect of crop rotation upon soil fertility and corn mineral nutrition. The results of this experiment are discussed in terms of nutrient synergisms whereby nutrient absorption proceeds at a faster rate than dry weight accumulation.
traits Autistic traits, adolescence, and anti-social peer

background The potential role of autism as a moderator of conformity has recently been investigated by a small number of studies. However, as yet, no consensus has emerged as to whether autism or autistic traits can moderate the degree to which people attend to and are influenced by social pressure, nor whether there are specific circumstances under which this might occur. The current study adds to this ambiguous literature by looking at whether autism and autistic traits are associated with conformity in the context of adolescent peer pressure.
related in and chronic fatigue syndrome: a comparative study

Background: Fatigue is a disabling, poorly understood symptom in children and adolescents with multiple sclerosis (caMS), for which effective treatments are lacking. In paediatric Chronic Fatigue Syndrome (CFS), effective psychological interventions have been developed based on psychosocial factors associated with fatigue. This study aimed to identify potentially modifiable factors of fatigue in caMS by comparing caMS, adolescents with CFS, healthy adolescents and their parents on measures of fatigue, psychosocial factors, and neurocognitive functioning. Methods: 175 participants including 30 caMS (15 fatigued, 15 non-fatigued), 30 adolescents with CFS, 30 healthy controls, and their parents were compared on measures of self- and parent-reported fatigue, adolescent and parent cognitive behavioural responses to symptoms, sleep, psychological difficulties, parental distress and objectively measured neurocognitive functioning. Results: Fatigue severity, functional impairment and cognitive behavioural responses to symptoms were equivalent in fatigued caMS and adolescents with CFS, and were significantly higher than in healthy controls and non-fatigued caMS. Neurocognitive functioning was impaired in both caMS groups, but was normal in adolescents with CFS and healthy controls. No between-group differences were identified in adolescent sleep behaviour or psychological difficulties. Parents of all illness groups had more unhelpful cognitions than parents of healthy controls. Psychological distress was elevated in parents of both fatigued groups. Conclusions: Fifty percent of caMS reported clinically significant fatigue. Similarities between adolescent and parent cognitive behavioural factors in fatigued caMS and adolescents with CFS suggest important potential targets for intervention. Both fatigued and non-fatigued caMS had cognitive difficulties, suggesting that fatigue may need targeted intervention. and non-fatigued caMS on any measure of neurocognitive functioning. Post-hoc Games-Howell tests showed no significant between group differences on processing speed (supplementary materials
TWO ELEMENT BAND-NOTCHED UWB MIMO ANTENNA WITH HIGH AND UNIFORM ISOLATION

In this paper, a single notched band at 5.2 GHz with complementary split ring resonator (CSRR) ultra-wideband (UWB) antenna and its implementation in designing of two-element multipleinput multiple-output (MIMO) with high and uniform isolation are experimentally demonstrated. The proposed UWB MIMO consists of a T-shaped stub in ground plane in between antenna elements of the size of λat3. 1 GHz/4 to achieve minimum 20 dB isolation, which is almost uniform in entire UWB band. The size of the UWB MIMO antenna is 0. 31λat3. 1 GHz × 0. 434λat3. 1 GHz × 0. 008λat3. 1 GHz mm3, and it is printed on an RT/duroid 5880 substrate (εr = 2.2, tan δ = 0.0009), which leads to good gain and high total efficiency of the antenna in operating bands. The simulated and measured results show good agreement for the impedance bandwidth (|S11| < −10 dB) and isolation (|S21| < −20 dB) in most of the operating band, excluding the notched band at 5.2 GHz in UWB range. The simulated, measured and calculated MIMO antenna diversity parameters prove that the antenna is suitable for UWB MIMO systems.
In-situ non-destructive analysis of Etruscan gold jewels with the micro-XRF transportable spectrometer from CNA

technical speci ﬁ cations of the micro-XRF spectrometer developed at the CNA in Seville is presented and its analytical capabilities are tested by means of the analysis of a set of Etruscan gold jewels of the National Archaeological Museum of Florence. Since these jewels are characterized by elaborate decorations, with details of typical dimensions down to tens of microns, a high lateral resolution is required to study the features of these objects. The challenge consists in the characterization of the welding/soldering zones and the details of the jewels that present a very complex geometry. This paper shows the micro-XRF in-situ analysis of 15 Etruscan gold jewels (from the VII century BCE) in order to characterize the alloy composition of sheets, threads, ﬁ ligrees, granules, as well as the joining zones. Based on these results, the manufacture technique and the production process employed by the Etruscan goldsmiths could be described.
Recognition of American Sign Language Gestures in 
a Virtual Reality Using Leap Motion

We perform gesture recognition in a Virtual Reality (VR) environment using dataproduced by the Leap Motion device. Leap Motion generates a virtual three-dimensional (3D) handmodel by recognizing and tracking user‘s hands. From this model, the Leap Motion applicationprogramming interface (API) provides hand and finger locations in the 3D space. We present asystem that is capable of learning gestures by using the data from the Leap Motion device and theHidden Markov classification (HMC) algorithm. We have achieved the gesture recognitionaccuracy (mean ± SD) is 86.1 ± 8.2% and gesture typing speed is 3.09 ± 0.53 words per minute(WPM), when recognizing the gestures of the American Sign Language (ASL).
Image segmentation technique-a comparative study

Image segmentation techniques aims at identification and extraction of foreground objects in an image resulting into individual segments. Segmentation of images basically are so varied from one type of image to other images as each had its own context and varied geometrical properties and thus leading to a challenge in design of a generic algorithmic procedure. In this paper, an effort is formed to compare and study the efficiency of color image segmentation victimization color areas, watersheds, fuzzy c-means and edge detection techniques towards the segmentation of fruit images. The fruit images employed for segmentation are downloaded from various sources of online and also few of the images are synthetically gathered by capturing the fruits images over a plain background. The analysis had resulted in conclusion that performance of fuzzy c -means and watersheds had led to optimal outcomes than other techniques.
Cloud Based Optimal Routing and Powertrain Management for Hybrid and Electric Vehicles

— Hybrid and electric vehicles have been gaining significant traction in the vehicle market for the past few years, and this necessitates that further attention should be given to their unique characteristics. This paper illustrates a combined route guidance and power management approach, where the required computation is distributed across an on-board/off-board system architecture. A model of the vehicle and the powertrain is utilized to calculate arc costs of a road network for optimal route guidance purposes, and the calculated power reference is later on used for dynamic programming based power management. This approach has the potential to improve vehicle efficiency significantly, and an application scenario based on recorded real world trip information is used to demonstrate system operation.
Infection mansoni Schistosoma B Cell Compartment during Regulation of the Development of the Hepatic

During infection with the helminth parasite Schistosoma mansoni , Ab regulates hepatic inﬂammation, and local production of Ig in the liver appears to play a role in this process. Exploring the development of the B cell response during infection, we found that parasite-speciﬁc IgG1-secreting plasma cells appeared ﬁrst in the hepatic and mesenteric lymph nodes (LNs) and then at later times in the spleen, liver, and bone marrow. The LN B cell population peaked between weeks 10 and 12 of infection, and then contracted at a time that coincided with the expansion of the hepatic IgG1 + B cell compartment, suggesting that B cells migrate from LNs to liver. CXCL9 and -16 expression in the liver increased during the time frame of B cell recruitment. Expression of the CXCL16 receptor CXCR6 was increased on B cells within the hepatic LNs, but not the mesenteric LNs. CXCR3, the receptor for CXCL9, was broadly expressed on IgG1 + B cells in LNs and liver during infection. Increased hepatic expression of CXCL9 and -16 failed to occur if the IL-10R was blocked in vivo, an intervention associated with decreased liver B cell inﬁltration and the development of severe disease. Hepatic LN IgG1 + cells migrated toward CXCL9 and -16 in vitro and to the liver in a pertussis toxin–sensitive fashion. Our data suggest that the coordinated expression of CXCL9 and -16 in the liver and of CXCR6 and CXCR3 on responding B cells within the hepatic LNs underpins establishment of the hepatic B cell inﬁltrate during chronic schistosomiasis. The Journal of Immunology , 2013, 191: 000–000.
Global Trends in Urban Agriculture Research: A Pathway toward Urban Resilience and Sustainability

Urban agriculture has been proposed as an important urban element to deal with the challenges of food insecurity and environmental deterioration. In order to track current popular topics and global research trends in urban agriculture, we used bibliometric analysis and visualization mapping to evaluate and analyze the developments in the knowledge of urban agriculture based on 605 papers from the core collection database Web of Science from 2001–2021. The results were as follows. (1) The number of urban agriculture publications increased substantially year by year, indicating that the field is attracting increasing attention. The University of Kassel, Chinese Academy of Sciences, and University of Freiburg are the most productive research institutions in the field of urban agriculture. The top-five most influential countries are the Unites States, Germany, the United Kingdom, Italy, and China, of which the Unites States plays a central role in the cooperative linkage between countries. (2) Research on urban agriculture focuses not only on food production and different styles but also on how to realize the various functions of urban agriculture. In addition, UA-related sustainability and the water-energy-food nexus have become two emerging research topics. (3) Urban agriculture does not necessarily mean a resource-conserving and environmentally friendly food system. To achieve sustainable development, a transition based on technological innovation is needed. How to improve the sustainable development level of the food system while fully considering the resilience, sustainability, and versatility of urban agriculture is the main direction of future research.
CMAR_A_275498 13301..13309

*These authors contributed equally to this work Background: The prognostic role of preoperative fibrinogen in colorectal cancer (CRC) patients remains controversial. Therefore, we assessed the predictive value of preoperative fibrinogen and developed a tool for predicting the survival of CRC patients. Methods: This retrospective study evaluated 1869 patients who underwent curative resection for CRC. Univariate and multivariate survival analyses were conducted to identify the factors correlated with overall survival (OS) and cancer-specific survival (CSS). Nomograms were developed as a graphical representation of the Cox proportional hazards regression models. The performance of the nomograms was assessed by Harrell’s concordance index (c-index) and calibration plots. Results: The preoperative fibrinogen levels were correlated with age, tumor differentiation, tumor location, pT category, and TNM stage. In the multivariate analysis, elevated fibrinogen level was independently correlated with worse OS and CSS (OS: hazard ratio [HR] = 0.777, 95% confidence interval [95% CI] = 0.630–0.958, P = 0.018; CSS: HR = 0.757, 95% CI = 0.605–0.947, P = 0.015). The nomograms could predict outcomes with a c-index for OS and CSS of 0.79 and 0.81, respectively. The nomograms also had a good calibration. Conclusion: Preoperative fibrinogen level was an independent marker of poor prognosis in patients with nonmetastatic CRC, and there was a threshold level for the use of fibrinogen as a prognostic factor. Furthermore, nomograms may help predict the individual risk of OS and CSS in patients treated for CRC.
Hepatic Steatosis and Metabolic Syndrome Variables: Overplay on the Progression of Fibrosis among Hepatitis C Mono-Infected Patients and Human Immunodeficiency Virus Co-Infected Patients

Background & Aims: Hepatic steatosis has been reported to be associated to increased fibrosis progression, reduced response rates to anti-HCV therapy and antiretroviral therapy for which it has clinical importance. This study was conducted to determine the impact of hepatic steatosis on the severity of liver disease progression in chronic HCV mono-infected and HIV/HCV co-infected patients. Methods: Retrospective study of patients with chronic HCV or HIV/HCV co- infection, with liver biopsies, at the Fundación de Investigación in Puerto Rico and the Bronx Veterans Affairs Medical Center in New York from 1998 to 2005. Results: Of the 1212 subjects, 834 (69%) were HCV mono-infected and 378 (31%) were HIV/HCV co-infected. Steatosis was more prevalent in HCV patients than HIV/HCV patients (51.2% vs. 39.7%, p=0.003). Severity of necroinflammatory grade was statistically associated to steatosis in HCV patients (p < 0.001), but not HIV/HCV patients (p=0.620). Severity of fibrosis progression rate was associated to steatosis in HCV patients (p=0.088), but not HIV/HCV patients (p=0.493). Hepatic steatosis increased the chances of fibrosis across all levels in the multivariate analysis (using a partial proportional odds model) in HCV patients, but not HIV/HCV patients. Conclusion: Hepatic steatosis is more prevalent in HCV mono-infected patients, than in HIV/HCV co-infected patients. Presence of steatosis impacted the progression of liver disease differently; it increased the severity of necroinflammatory grade, the fibrosis progression rate and the chances of fibrosis in HCV mono-infected patients, but not in HIV/HCV co-infected patients.
FROM MEMORIES TO MEMORIAL: HEALING GRIEF THROUGH MOVING IMAGE CREATION

Mourning is a period of our life that affects us deeply, and could be very traumatic in some cases. Art has been and still is a great way to express non-verbally our deeper feelings, finding meaning to our condition and in the case of mourning, our loss. Photography and Moving images are both medium that have a strong connection with death by embalming time, they can also be used as tools to ease the pain during mourning, and to move forward in our life. This study summarizes first some basic psychology concepts about bereavement and art therapy before focusing on the use of moving images as a healing tool for grief. This study compared the creation of moving images as a tool for healing grief both in art therapy and as a creative process by practitioners who experienced grief. The last part is a case study based on the author’s own experience with dealing with grief through the making of an animation in memory of his lost partner. Through the case study, the author explores the process of making the animation and its positive effect on his grief.
UDDWE: Universal domain deep web exposer

Traditionally, the search engines were able to extract web data which is smaller in size as compared to much relevant and quality data (also called hidden web data) hidden behind search interfaces. A lot of research has been done to extract this web data to fetch its relevant and quality content. However, most of the methods are domain specific i.e. for multiple domains multiple tools are designed. In this paper, a novel method is proposed to present one universal tool for all the domains. The key point in this approach is the customization of the traditional search engine to receive the user query to process it for identifying the entry points (search interfaces) to the hidden web. After this filtering process, the entry points are presented for opening in a controlled programmed environment to ease the data extraction process.
IGAUNA (Improved Global Sequence Alignment Using Non-exact Anchors)

With the sequencing of the entire genome for many species, bioinformaticians are increasingly relying on efficient whole genome alignment tools exhibiting both high sensitivity and specificity. We introduce and analyze IGAUNA (Improved Global Alignment Using Non-exact Anchors), a new global alignment algorithm based on GAUNA, which in comparison with the other state-of-the-art algorithms, almost always produces as good or better alignments with high sensitivity and specificity using less time and space. While those tools either find exact or close-to-exact matches as anchors, IGAUNA makes use of suffix trees to find both types of anchors depending on the instance: Exact anchors for very similar sequences and otherwise non-exact anchors that are obtained from a complicated set of techniques. In particular, IGAUNA can rapidly align sequences containing millions of bases on a standard PC where other similar programs are currently incapable of accomplishing such a task.