Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Narrative on Physical Activity via Immersion During Active Video Game Play in Children: Mediation Analysis

Background Active video games (AVGs) can increase physical activity (PA) and help produce higher physiological expenditure. Animated narrative videos (NVs) possess unique immersive and motivational properties. When added to AVGs, they have been found to increase moderate-to-vigorous physical activity (MVPA) as opposed to the original no video condition. However, there is no evidence of whether that was due to the NV or the addition of an animated video to an AVG. Objective This study aimed to investigate the differential effect of adding an NV versus a nonnarrative video (NNV) to an AVG on PA parameters and physiological responses and to explore the mediating role of immersion. Methods A total of 22 children aged 8 to 12 years were randomly assigned to the NV or NNV condition. They were instructed to play an AVG (on Xbox Kinect) for as long as they wanted. We used accelerometers to estimate the time spent (in minutes) in MVPA. Heart rate (HR) and rate of perceived exertion (RPE) were measured before, during, and after the AVG play session. The participants then reported their experience of narrative immersion via a questionnaire. Results The NV group had significantly higher narrative immersion (mean 3.50, SD 0.55 vs mean 2.91, SD 0.59; P=.03) and MVPA (mean 19.46, SD 13.31 vs mean 7.85, SD 5.83; P=.02) than the NNV group. Narrative immersion was positively correlated with MVPA (r=0.52; P=.01) and average HR during AVG (r=0.43; P=.05). Mediation analysis indicated that narrative immersion mediated the effect of NV (NV vs NNV) on MVPA (direct effect: beta=7.51; P=.01). The indirect effect was that NV was positively correlated with the mediator variable narrative immersion (beta=.59; P=.03), which was itself marginally associated with MVPA (beta=6.95; P=.09); when narrative immersion was included in the model, the regression coefficient was attenuated. Conclusions AVG with added narratives elicits more narrative immersion, resulting in more minutes in MVPA. Narrative immersion served as a mediator between NV and MVPA via its elicitation of an elevated HR without increasing RPE. The inclusion of immersive narratives in AVG could be helpful for inducing MVPA, to enhance AVG engagement without additional exertion.
The Effect of Alcohol on Cardiovascular Risk Factors: Is There New Information?

The effects of alcohol on cardiovascular health are heterogeneous and vary according to consumption dose and pattern. These effects have classically been described as having a J-shaped curve, in which low-to-moderate consumption is associated with less risk than lifetime abstention, and heavy drinkers show the highest risk. Nonetheless, the beneficial effects of alcohol have been questioned due to the difficulties in establishing a safe drinking threshold. This review focuses on the association between alcohol consumption and cardiovascular risk factors and the underlying mechanisms of damage, with review of the literature from the last 10 years.
Association of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) with Muscle Strength in Community-Dwelling Elderly with Knee Osteoarthritis

Purpose: The purpose of this study was to evaluate the correlation between muscle strength and knee symptoms (pain, stiffness, and functional limitation) regardless of the presence of radiologic knee osteoarthritis (RKOA) in community-dwelling elderly. Patients and methods: This cross-sectional study used data from the Namgaram-2 cohort. The Namgaram-2 cohort consisted of participants living in three rural communities. Such participants were included for studies on activity limitation due to age-related musculoskeletal disorders including knee osteoarthritis, osteoporosis, and sarcopenia. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), a health assessment tool for patients with arthritis in lower extremities, was used to assess health-related quality of life (HRQOL). Muscle strengths were measured by knee strength (by using the isokinetic dynamometer) and hand grip strength. Results: The WOMAC pain of Kallgren–Lawrence (K/L) grade < 2 was correlated with age, grip strength, nutrition status, and knee extension 180 peak torque. The WOMAC pain of K/L grade ≥ 2 was correlated with age, nutrition status, and knee extension 60 peak torque. The WOMAC stiffness of K/L grade < 2 was correlated with having a spouse, nutrition status, and knee extension 60 peak torque. The WOMAC stiffness of K/L grade ≥ 2 was correlated with knee extension 60 peak torque. The WOMAC function of K/L grade < 2 was correlated with age, grip strength, osteoporosis, nutrition status, and knee extension 180 peak torque. The WOMAC function of K/L grade ≥ 2 was correlated with age, nutrition status, and knee extension 60 peak torque. Conclusion: Muscle strength as measured by grip strength and knee extension was statistically significantly correlated with the WOMAC scores in patients with knee symptoms regardless of whether radiologic signs of knee osteoarthritis were observed.
Metal-Organic Framework Glasses possess Higher Thermal Conductivity than their Crystalline Counterparts.

The thermal conductivity (κ) of glasses is known to always be lower than that of their corresponding crystals due to the stronger phonon-phonon scattering in the former. However, it is unknown whether this relation holds for metal-organic frameworks. Here, we report our discovery of an inverse relation in κ between glass and crystal for two zeolitic imidazolate frameworks (ZIFs), ZIF-4 and ZIF-62, i.e., melt-quenched ZIF-4 and ZIF-62 glasses possess higher thermal conductivities than their crystalline counterparts. We find that the ZIF crystal pellets exhibit ultralow κ (~0.1 W m-1 K-1), and that the higher κ of the ZIF glasses is due to the collapse of internal cavities and higher atomic number density in the latter. For other systems like oxides, vitrification causes higher free volume, but the opposite is found for the ZIFs, i.e., lower free volume owing to the partial collapse of the crystalline framework upon melting.
Associations of breeding-bird abundance with climate vary among species and trait-based groups in southern California

The responses of individuals and populations to climate change vary as functions of physiology, ecology, and plasticity. We investigated whether annual variation in seasonal temperature and precipitation was associated with relative abundances of breeding bird species at local and regional levels in southern California, USA, from 1968–2013. We tested our hypotheses that abundances were correlated positively with precipitation and negatively with temperature in this semiarid to arid region. We also examined whether responses to climate varied among groups of species with similar land-cover associations, nesting locations, and migratory patterns. We investigated relations between seasonal climate variables and the relative abundances of 41 species as estimated by the North American Breeding Bird Survey. Associations with climate variables varied among species. Results of models of species associated with arid scrublands or that nest on the ground strongly supported our hypotheses, whereas those of species associated with coniferous forests or that nest in cavities did not. Associations between climate variables and the abundances of other trait-based groups were diverse. Our results suggest that species in arid areas may be negatively affected by increased temperature and aridity, but species in nearby areas that are cooler and less arid may respond positively to those fluctuations in climate. Relations with climate variables can differ among similar species, and such knowledge may inform projections of future abundance trajectories and geographic ranges.
Subcellular Localization of Copper—Cellular Bioimaging with Focus on Neurological Disorders

As an essential trace element, copper plays a pivotal role in physiological body functions. In fact, dysregulated copper homeostasis has been clearly linked to neurological disorders including Wilson and Alzheimer’s disease. Such neurodegenerative diseases are associated with progressive loss of neurons and thus impaired brain functions. However, the underlying mechanisms are not fully understood. Characterization of the element species and their subcellular localization is of great importance to uncover cellular mechanisms. Recent research activities focus on the question of how copper contributes to the pathological findings. Cellular bioimaging of copper is an essential key to accomplish this objective. Besides information on the spatial distribution and chemical properties of copper, other essential trace elements can be localized in parallel. Highly sensitive and high spatial resolution techniques such as LA-ICP-MS, TEM-EDS, S-XRF and NanoSIMS are required for elemental mapping on subcellular level. This review summarizes state-of-the-art techniques in the field of bioimaging. Their strengths and limitations will be discussed with particular focus on potential applications for the elucidation of copper-related diseases. Based on such investigations, further information on cellular processes and mechanisms can be derived under physiological and pathological conditions. Bioimaging studies might enable the clarification of the role of copper in the context of neurodegenerative diseases and provide an important basis to develop therapeutic strategies for reduction or even prevention of copper-related disorders and their pathological consequences.
Pro Drupal Development

Pro Drupal 7 Development updates the most popular development reference for the newest major release of Drupal. With several new and completely-rewritten essential APIs and improvements in Drupal 7, this book will not only teach developers how to write modules ranging from simple to complex, but also how Drupal itself works. Learn the Drupal APIs and major changes in Drupal 7 Learn how to write Drupal modules using the APIs Learn proper development practices and how to become a contributing community member What youll learn How to get started with writing basic modules The flexible Drupal APIs and how they interact with modules How new features in Drupal 7 make modules even more powerful and sophisticated Best practices when developing in Drupal (coding standards, help developer modules) How to write safe, secure, and tested code How to contribute modules back to the Drupal community and maintain their modules using CVS Who this book is for This book is for existing Drupal module developers wanting to learn about Drupal 7 and people already knowledgeable in PHP who are interested in developing for Drupal. Simply put, if you are working with Drupal, then you need this book. Table of Contents How Drupal Works Writing a Module Hooks, Actions, and Triggers The Menu System Working with Databases Working with Users Working with Nodes Working with Fields The Theme System Working with Blocks The Form API Manipulating User Input: The Filter System Searching and Indexing Content Working with Files Working with Taxonomy Caching Sessions Using jQuery Localization and Translation XML-RPC Writing Secure Code Development Best Practices Optimizing Drupal Installation Profiles Testing Database Table Reference Resources
Bipolar hemiarthroplasty versus total hip arthroplasty in allograft-prosthesis composite reconstruction of the proximal femur following primary bone tumour resection.

AIMS The consensus is that bipolar hemiarthroplasty (BHA) in allograft-prosthesis composite (APC) reconstruction of the proximal femur following primary tumour resection provides more stability than total hip arthroplasty (THA). However, no comparative study has been performed. In this study, we have compared the outcome and complication rates of these two methods. METHODS In a retrospective study, 57 patients who underwent APC reconstruction of proximal femur following the primary tumour resection, either using BHA (29) or THA (28), were included. Functional outcome was assessed using the Musculoskeletal Tumour Society (MSTS) scoring system and Harris Hip Score (HHS). Postoperative complications of the two techniques were also compared. RESULTS The mean follow-up of the patients was 8.3 years (standard deviation (SD) 5.5) in the BHA and 6.9 years (SD 4.7) in the THA group. The mean HHS was 65 (SD 16.6) in the BHA group and 88 (SD 11.9) in the THA group (p = 0.036). The mean MSTS score of the patients was 73.3% (SD 16.1%) in the BHA and 86.7% (SD 12.2%) in the THA group (p = 0.041). Limping was recorded in 19 patients (65.5%) of the BHA group and five patients (17.8%) of the THA group (p < 0.001). Dislocation occurred in three patients (10.3%) of the BHA group and two patients (7.1%) of the THA group. CONCLUSION While the dislocation rate was not higher in THA than with BHA, the functional outcome was significantly superior. Based on our results, we recommend THA in APC reconstruction of the proximal femur. Cite this article: Bone Joint J 2020;102-B(4):524-529.
Understanding the Role of Temperature and Drain Current Stress in InSnZnO TFTs with Various Active Layer Thicknesses

Thin-film transistor (TFT) devices composed of metal oxide semiconductors have attracted tremendous research attention globally in recent years. Owing to their ability to offer mobility, metal oxide semiconductor materials can enable high-performance TFTs for next-generation integrated display devices. Nevertheless, further breakthroughs of metal oxide TFTs are mainly obstructed by their long-term variability, the reason for which is not yet fully understood. Herein, TFTs based on InSnZnO (ITZO) with various thicknesses (TITZO) were prepared and their long-term stabilities under test temperatures and drain current stress were investigated. The results indicate that ITZO TFTs exhibit outstanding electrical properties regardless of the TITZO, including a high saturated mobility of over 35 cm2V−1s−1 and sharp subthreshold swing. Note that the transfer and output characteristic curves of the device with a thick TITZO of 100 nm express an abnormal current surge when high gate and drain voltages are exerted, which is attributed to the floating body effect, caused when the imposed electric field induces impact ionization near the drain side. More interestingly, these drain current stress results further suggest that the abnormal shift behavior of the electrical properties of the ITZO TFTs with a TITZO of greater than 75 nm is observed to deteriorate gradually with increasing temperature and drain current bias. This study addresses that such a degradation effect should be restrained for the operation of high-mobility devices.
Biophysical and Immunological Characterization and In Vivo Pharmacokinetics and Toxicology in Nonhuman Primates of the Anti-PD-1 Antibody Pembrolizumab

The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint, which may be engaged by cells in the tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®, MK-3475) is a potent and highly selective humanized mAb of the IgG4/kappa isotype designed to directly block the interaction between PD-1 and its ligands, PD-L1 and PD-L2. This blockade enhances the functional activity of T cells to facilitate tumor regression and ultimately immune rejection. Pembrolizumab binds to human and cynomolgus monkey PD-1 with picomolar affinity and blocks the binding of human and cynomolgus monkey PD-1 to PD-L1 and PD-L2 with comparable potency. Pembrolizumab binds both the C′D and FG loops of PD-1. Pembrolizumab overcomes human and cynomolgus monkey PD-L1–mediated immune suppression in T-cell cultures by enhancing IL2 production following staphylococcal enterotoxin B stimulation of healthy donor and cancer patient cells, and IFNγ production in human primary tumor histoculture. Ex vivo and in vitro studies with human and primate T cells show that pembrolizumab enhances antigen-specific T-cell IFNγ and IL2 production. Pembrolizumab does not mediate FcR or complement-driven effector function against PD-1–expressing cells. Pembrolizumab displays dose-dependent clearance and half-life in cynomolgus monkey pharmacokinetic and toxicokinetic studies typical for human IgG4 antibodies. In nonhuman primate toxicology studies, no findings of toxicologic significance were observed. The preclinical data for pembrolizumab are consistent with the clinical anticancer activity and safety that has been demonstrated in human clinical trials.
Non-invasive Myocardial Strain Imaging to Evaluate Graft Failure in Cardiac Xenotransplantation

Background: The shortage of human hearts for allotransplantation makes xenotransplantation a possible option for controllable organ providers. To detect acute xenograft rejection, invasive biopsy seems inevitable; however, this occasionally results in poor incision wound healing or infection. To date, no method of noninvasive imaging for early detection of xenograft rejection has been established. We hypothesized that ultrasound speckle tracking would better detect xenograft failure than routine left ventricular ejection fractions (EF). Methods: From August 2013 to July 2015, a total of six cardiac heterotopic xenotransplants (  1, 3-galactosyltransferase gene-knockout porcine heart) into cynomolgus monkeys were monitored with echocardiography every 3 to 7 days. M-mode and two-dimensional (2D)-EF measurements and myocardial strain analyses were performed. Cardiac xenograft pathology was reviewed from the immediate postoperative biopsy, as well as the necropsy. Results: Myocardial speckle tracking analysis was feasible in all six cases. The longest survival was 43 days. Only one pathol-ogy-proven immunologic rejection occurred. Cardiac xenograft failure appeared as two types: a dilated pattern with decreased EF or a myocardial-thickening pattern with preserved EF. Both antibody-mediated rejection (n=1) and sepsis-induced myocardial dysfunction (n=2) revealed decreased radial or circumferential strains, but normal-range EF. Xenograft functional decline was significant with respect to radial or circumferential strain (P=0.028), but not to conventional M-mode or 2D-EFs (P=0.600, P=0.340, respectively). Conclusions: Radial and circumferential strains were significantly decreased in both types of xenograft failure, regardless of EF. Further studies are warranted to correlate the strain analysis and immunopathological
With a transaction fee market and without a block size limit in Bitcoin network; there exists a Nash equilibrium points of the mining game

We are interested in mining incentives in the Bitcoin protocols. The blockchain Bitcoin. The mining process is used to conﬁrm and secure all transactions in the network. This process is organized as a speed game between individuals or groups, referred to as “miners” or “pools of miners”, respectively. Miners or pools of miners use different computational powers to solve a mathematical problem, obtain a proof-of-work, spread their solution, and this solution is veriﬁed by the community before the block is added in the only public blockchain replicated over all nodes. First, we deﬁne and specify this game in the case with n players, n ≥ 2 , under the assumptions denoted by (H) below. Next, we analytically ﬁnd its Nash equilibrium points. In other words, we generalize the idea of [1] by taking into account the hypotheses of Peter Rizun’s paper [2], through cumbersome computations. Our purpose here is to show some intuitions about the model rather than derive applicable results.
Improved Performance of Turbo Codes using Iterative decoding with additional Convolutional Interleaver

--Turbo codes are most powerful channel codes which have very high decoding complexity. This paper adopts an improved model for Turbo codes by using additional interleaver in the system. The proposed additional interleaver considered here is Convolutional interleaver which can achieve better error rate performance than other interleavers with reduced number of iterations. Simulation results shows that the proposed model performance with and without additional convolutional interleaver in AWGN Channel.
Design of an adaptive JPEG Steganalysis with UED

: Steganography is the art and science of writing hidden messages in such a way that no one apart from the sender and intended recipient suspects the existence of the message a form of security through obscurity. The internet as a whole does not use secure links, thus information in transit may be vulnerable to interception as well. The important of reducing a chance of the information being detected during the transmission is being an issue now days. In this paper, we proposed a class of new distortion functions known as uniform embedding distortion function (UED) is presented. By incorporating the syndrome trellis coding, the best code word with undetectable data hiding is achieved. Due to hiding more amounts of data into the intersected area, embedding capacity is increased. Our aim is to hide the secret information behind the image file. Steganography hides the secret message so that intruder’s can’t detect the communication. When hiding data into the intersected area, thus provides a higher level of security with more efficient data mean square error is reduced and embedding capacity is increased.
Building Confidential & Efficient Query Services in the Cloud with RASP Perturbation

: - In this paper Cloud computing infrastructures are popularly used by peoples now a days. By using cloud users can save their cost for query services. But some of the data owners are hesitate to put their data’s in cloud because, some-times the data may be hack when they use in cloud unless the confidentiality of data and secure query processing will be provided by the cloud provider.However, some data might be sensitive that the data owner does not want to move to the cloud unless the data confidentiality and query privacy are guaranteed. We propose the Random Space Encryption (RASP) approach that allows efficient range search with stronger attack resilience than existing efficiency-focused approaches. The random space perturbation (RASP) data perturbation method to provide secure and efficient range query and kNN query services for protected data in the cloud. The RASP data perturbation method combines order preserving encryption, dimensionality expansion, random noise injection, and random projection, to provide strong resilience to attacks on the perturbed data and queries. It also preserves multidimensional ranges, which allows existing indexing techniques to be applied to speedup range query processing. The kNN-R algorithm is designed to work with the RASP range query algorithm to process the kNN queries.