Miracle-dz/UniFAR-FTUs huggingface dataset:
Control of pushing operation by a redundant manipulator

This paper describes a new approach to pushing operation from one place to another. Pushing operation doesn't need a complicated structure of the end effector in comparison with grasping object. Therefore it is available for multipurpose. However pushing is more instability than pulling and grasping from dynamics' point of view. Hence it is thought that its control system will be complexity. Then, in this paper, the new control method about pushing operation from one place to another by a redundant manipulator is proposed. The purpose of this research is that the center of the object tracks a certain trajectory(in this paper, sin curve) exactly. In this paper, a work space observer is adopted so as to compensate the disturbance to the object. Therefore, the acceleration control system in the object coordinate is necessary to be constructed. Basically, the drive of the object in the translational direction is realized by impedance control and the moment of the object is realized by changing the point which the end effector touches.
Awareness systems: known results, theory, concepts and future challenges

INTRODUCTION Technological developments and research in awareness systems have come a long way, since early experiences at Xerox with Media Spaces. An important finding of that early work, was that one of the most significant benefits to users of Media Spaces [1] was the peripheral awareness colleagues had of each other and of the general activity at their and the remote working environments. Several research projects have since pursued this path further, setting the awareness of people and places as one of their primary goals and giving rise to a subclass of computer mediated communication systems called awareness systems.
Reproducible stool metagenomic biomarkers linked to the melanoma immunotherapy positive outcome

The human gut microbiome plays an important role both in human’s health and disease. Recent studies have shown the undeniable influence of gut microbiota composition on cancer immunotherapy efficacy. However, these researches show a lack of consensus in defining reproducible metagenomic markers for a positive immunotherapy outcome. Accordingly, extended published data re-analysis may help reveal clearer associations between the composition of the gut microbiota and treatment response. In this study, we analyzed 358 stool metagenomes from 5 studies published earlier: 210 metagenomes from melanoma patients with positive immunotherapy outcome, 148 metagenomes from melanoma patients with negative immunotherapy outcome. The biomarkers were selected by the group comparison of patients’ stool samples with different treatment responses (47 responders vs 55 non-responders, 102 metagenomes). Selected biomarkers were verified using the available data describing the influence of the fecal microbiota transplantation on melanoma immunotherapy outcomes (9 donors, 6 responders, 19 non-responders, 256 metagenomes). According to our analysis, the resulting cross-study reproducible taxonomic biomarkers correspond to 12 Firmicutes, 4 Bacteroidetes, and 3 Actinobacteria. 140 gene groups were identified as reproducible functional biomarkers, including those potentially involved in production of immune-stimulating molecules and metabolites. In addition, we ranked taxonomic biomarkers by the number of functional biomarkers found in their metagenomic context. In other words, we predicted a list of the potential “most beneficial” bacteria for a positive response to melanoma immunotherapy. The obtained results can be used to make recommendations for the gut microbiota correction in cancer immunotherapy, and the resulting list of biomarkers can be considered for potential diagnostic ways for predicting melanoma immunotherapy outcome. Another important point is the functional biomarkers of positive immunotherapy outcome are distributed in different bacterial species that can explain the lack of consensus of defining melanoma immunotherapy beneficial species between different studies.
Description of Halopseudomonas maritima sp. nov., based on phylogenomic analysis

A novel bacterium, strain RR6T of the genus Halopseudomonas, was isolated from the sea sand from Paradip port area, India. Cells are Gram-stain-negative, rod-shaped, aerobic, non-sporulating and motile. The major cellular fatty acids of RR6T were C10:0 3OH, C12:0, C16:1 w7c/16:1 w6c, 18:1 w7c and/or 18:1 w6c and C16:0. The predominant polar lipids were phosphatidylglycerol (PG), diphosphatidylglycerol (DPG), phosphatidylethanolamine (PE), phosphatidylcholine (PC), unidentified phospholipid (PL) and unidentified lipids (L1-L2). The genome size of the strain RR6 was 3.93 Mb. The genomic G+C content was 61.3%. Gene ontology study showed a significant fraction of genes were associated with biological processes (53%), followed by molecular function (36%) and cellular components (11%). Comparisons of 16S rRNA gene sequences revealed 99.73 - 99.87 % sequence similarity with the closely related type strains of the genus Halopseudomonas. The average nucleotide identity (ANI) and average amino acid identity (AAI) of RR6T with reference strains of closely related species of the genus Halopseudomonas were below 95–96, and the corresponding in-silico DNA–DNA hybridization (DDH) values were below 70 %. A phylogenomic tree based on core genome analysis supported these results. Genotypic and phenotypic characteristics of RR6T indicate that the strain represents a novel species of the genus Halopseudomonas and the name Halopseudomonas maritima sp. nov. is proposed. The type strain is RR6T (= NBRC 115418T = TBRC 15628T).
Flow Sorting of Marine Bacterioplankton after Fluorescence In Situ Hybridization

ABSTRACT We describe an approach to sort cells from coastal North Sea bacterioplankton by flow cytometry after in situ hybridization with rRNA-targeted horseradish peroxidase-labeled oligonucleotide probes and catalyzed fluorescent reporter deposition (CARD-FISH). In a sample from spring 2003 >90% of the cells were detected by CARD-FISH with a bacterial probe (EUB338). Approximately 30% of the microbial assemblage was affiliated with the Cytophaga-Flavobacterium lineage of the Bacteroidetes (CFB group) (probe CF319a), and almost 10% was targeted by a probe for the β-proteobacteria (probe BET42a). A protocol was optimized to detach cells hybridized with EUB338, BET42a, and CF319a from membrane filters (recovery rate, 70%) and to sort the cells by flow cytometry. The purity of sorted cells was >95%. 16S rRNA gene clone libraries were constructed from hybridized and sorted cells (S-EUB, S-BET, and S-CF libraries) and from unhybridized and unsorted cells (UNHYB library). Sequences related to the CFB group were significantly more frequent in the S-CF library (66%) than in the UNHYB library (13%). No enrichment of β-proteobacterial sequence types was found in the S-BET library, but novel sequences related to Nitrosospira were found exclusively in this library. These bacteria, together with members of marine clade OM43, represented >90% of the β-proteobacteria in the water sample, as determined by CARD-FISH with specific probes. This illustrates that a combination of CARD-FISH and flow sorting might be a powerful approach to study the diversity and potentially the activity and the genomes of different bacterial populations in aquatic habitats.
The E.coli fis promoter is subject to stringent control and autoregulation.

The DNA binding protein FIS is involved in processes like site specific DNA inversion, lambda excision and stimulation of stable RNA synthesis in Escherichia coli. The amount of FIS protein is subject to dramatic changes during growth. We demonstrate that fis is part of an operon with one ORF of unknown function preceding the fis gene. Regulation of fis synthesis occurs at the transcriptional level. Within 15 min after nutritional upshift a large burst of fis mRNA is produced which levels off when cells begin to grow. By mutational analysis using promoter‐lacZ fusions we demonstrate that the fis promoter is autoregulated by FIS. Growth phase regulation of the fis promoter depends on the presence of a GC motif downstream of the −10 region. We show that the fis promoter is subject to stringent control and discuss this unusual feature with respect to the known and putative functions FIS serves in E. coli.
PMA‐induced activation of the p42/44ERK‐ and p38RK‐MAP kinase cascades in HL‐60 cells is PKC dependent but not essential for differentiation to the macrophage‐like phenotype

The signaling mechanisms leading to phorbol ester myristate (PMA)‐induced differentiation of HL‐60 cells to the macrophagelike phenotype were investigated by using different protein kinase inhibitors. The protein kinase C inhibitor Ro 31‐8220 specifically blocks PMA‐induced differentiation, activation of the p42/44ERK‐ and p38RK‐MAP kinase cascades and Hsp27‐phosphorylation in HL‐60 cells. Because Ro 31‐8220 does not inhibit activation of the MAP kinase cascades by protein kinase C (PKC)‐independent signals such as epidermal growth factor (EGF), heat shock, or anisomycin in these cells, only PMA‐induced activation of the MAP kinases can be downstream of PKC. The MEK1 inhibitor PD 098059 and the p38RK inhibitor SB 203580 also were used to analyze whether the PMA‐induced PKC‐dependent activation of MAP kinases is involved in the differentiation process. Under certain conditions, PD 098059 can completely block the PMA‐induced activation of the p42ERK as monitored by imunoprecipitation kinase assay by using the substrate myelin basic protein. SB 203580 specifically inhibits activation of p38RK as judged by MAPKAP kinase 2 activity against the substrate Hsp27 and also blocks Hsp27 phosphorylation in the cells. In contrast, neither PD 098059 nor SB 203580 nor both inhibitors together prevent PMA‐induced differentiation of the HL‐60 cells to the macrophagelike phenotype. The results suggest the existence of a diversification of PMA‐induced signaling in HL‐60 cells downstream of PKC, leading to activation of MAP kinases that are not essential for differentiation and to phosphorylation of other, so far unidentified, targets responsible for differentiation. J. Cell. Physiol. 173:310–318, 1997. © 1997 Wiley‐Liss, Inc.
Seasonal Temperature Changes Do Not Affect Cardiac Glucose Metabolism

FDG-PET/CT is widely used to diagnose cardiac inflammation such as cardiac sarcoidosis. Physiological myocardial FDG uptake often creates a problem when assessing the possible pathological glucose metabolism of the heart. Several factors, such as fasting, blood glucose, and hormone levels, influence normal myocardial glucose metabolism. The effect of outdoor temperature on myocardial FDG uptake has not been reported before. We retrospectively reviewed 29 cancer patients who underwent PET scans in warm summer months and again in cold winter months. We obtained myocardial, liver, and mediastinal standardized uptake values (SUVs) as well as quantitative cardiac heterogeneity and the myocardial FDG uptake pattern. We also compared age and body mass index to other variables. The mean myocardial FDG uptake showed no significant difference between summer and winter months. Average outdoor temperature did not correlate significantly with myocardial SUVmax in either summer or winter. The heterogeneity of myocardial FDG uptake did not differ significantly between seasons. Outdoor temperature seems to have no significant effect on myocardial FDG uptake or heterogeneity. Therefore, warming the patients prior to attending cardiac PET studies in order to reduce physiological myocardial FDG uptake seems to be unnecessary.
Women with endometriosis have a higher DNA repair capacity and diminished breast cancer risk.

INTRODUCTION Breast cancer (BC) and endometriosis are important reproductive health diseases for women. Although endometriosis is not a malignant condition, some of its characteristics mimic that of a malignancy. Endometriosis is associated with increased risk of certain cancers; however, whether it alters BC risk is unclear. This study evaluates the association of endometriosis and BC and explores whether DNA repair capacity (DRC) plays a role in such a relationship. MATERIALS AND METHODS A case-control study of 991 women (385 with BC and 606 controls, all recruited over 5 years) was undertaken in Puerto Rico. Eighty participants with self-reported surgically diagnosed endometriosis were identified, 20 of whom also had a diagnosis of BC. Data from a structured questionnaire and DRC measurements were assessed to determine the association between BC, DRC, and endometriosis. RESULTS Participants with BC cases were 50% less likely to have history of endometriosis (OR = 0.5 95%CI: 0.3, 0.9, p = 0.038) than women without BC controls. Findings that did not reach statistical significance included the following: women with history of endometriosis had a slightly higher DRC level than those without it; BC cases and history of endometriosis were less likely to have had endometriosis diagnosis before age 38 as compared to controls with endometriosis. DISCUSSION Here we report an inverse association between endometriosis and BC, the former possibly conferring a protective effect on the latter. Although the mechanisms involved are unknown they may include protection provided by higher DRC and or hormonal treatments for endometriosis. A larger sample of endometriosis cases is necessary to confirm these results and answer the question of whether a higher DRC capacity may contribute to this potential protection, and to identify other factors at play.
Functional Changes of Rat Brain Microsomal Membrane Surface After Learning Task Depending on Dietary Fatty Acids

Abstract: Biochemical characteristics of brain microsomal membranes were examined before and after the brightness‐discrimination learning tasks in rats that were fed either safflower oil (α‐linolenate‐deficient) or perilla oil (α‐linolenate‐sufficient) diets. We detected small changes in the chain elongation system for polyunsaturated fatty acids in microsomes, whereas no significant difference was detected in the inositol trisphosphate‐induced calcium release and ATP‐induced calcium uptake profiles of microsomes between the two dietary groups. The calcium ion‐induced aggregation rate of microsomes was determined in both groups. We found that the aggregation rate of microsomes in the safflower oil group was significantly greater than that in the perilla oil group. The difference in susceptibility of microsomal membrane phospholipids to phospholipase A2 between the groups was obvious, and the amount of released fatty acids by phospholipase A2 from the perilla oil group microsomes was nearly half of that from the safflower oil group microsomes after the learning task. Susceptibility of sialic acids on the brain microsomal membranes to exogenous sialidase was different only after the learning task in the safflower and perilla oil groups. These results suggest that the biochemical characteristics of membrane surfaces of brain microsomes are affected significantly by the learning task itself in a dietary oil‐dependent manner.
Treemaps zoomables: techniques d'interaction multi-échelles pour les treemaps

Some efficient visualizations (such as treemaps) have been proposed for trees, but the interaction they provide to explore and acces data is often poor, especially for very large trees. We have designed a consistent set of navigation techniques that makes it possible to use treemaps as zoomable interfaces. We introduce structure-aware navigation, the property of using the structure of the displayed information to guide navigation, property that our interaction techniques share.
Alias burying: Unique variables without destructive reads

An unshared object can be accessed without regard to possible conflicts with other parts of a system, whether concurrent or single‐threaded. A unique variable (sometimes known as a ‘free’ or ‘linear’ variable) is one that either is null or else refers to an unshared object. Being able to declare and check which variables are unique improves a programmer's ability to avoid program faults.
Impact of non-uniform correlation structure on sample size and power in multiple-period cluster randomised trials

Stepped wedge and cluster randomised crossover trials are examples of cluster randomised designs conducted over multiple time periods that are being used with increasing frequency in health research. Recent systematic reviews of both of these designs indicate that the within-cluster correlation is typically taken account of in the analysis of data using a random intercept mixed model, implying a constant correlation between any two individuals in the same cluster no matter how far apart in time they are measured: within-period and between-period intra-cluster correlations are assumed to be identical. Recently proposed extensions allow the within- and between-period intra-cluster correlations to differ, although these methods require that all between-period intra-cluster correlations are identical, which may not be appropriate in all situations. Motivated by a proposed intensive care cluster randomised trial, we propose an alternative correlation structure for repeated cross-sectional multiple-period cluster randomised trials in which the between-period intra-cluster correlation is allowed to decay depending on the distance between measurements. We present results for the variance of treatment effect estimators for varying amounts of decay, investigating the consequences of the variation in decay on sample size planning for stepped wedge, cluster crossover and multiple-period parallel-arm cluster randomised trials. We also investigate the impact of assuming constant between-period intra-cluster correlations instead of decaying between-period intra-cluster correlations. Our results indicate that in certain design configurations, including the one corresponding to the proposed trial, a correlation decay can have an important impact on variances of treatment effect estimators, and hence on sample size and power. An R Shiny app allows readers to interactively explore the impact of correlation decay.
Investigation of the Abrasive Lapping Process of Oxide Ceramics

In this paper the methods of ceramic materials treatments are summarized. For the treatment of a technical ceramics the grinding and finishing processes including the description of the treatment steps are reported. In the first step, up to 80% of the material is polished away and the grinding is carried out at increased velocities using a tool with larger grains. In the second step of grinding, the amount of the removed material is decreased and this step is carried out using the abrasive tool with smaller grains. The third step referred as finishing is done by diamond abrasive micro-powders and a paste with a certain grain size. Often, after this step the polishing is performed in order to achieve the precision class of 1-3 and low surface roughness. The abrasive finishing of the materials based on the oxide ceramics VSH-75 is investigated. It is found that the performance ability of the diamond micro-powder is higher by a factor of 15-30 compared to the electrocorundum and green silicon carbide micro-powders. By increasing the graininess, the amount of removed material and the roughness of a treated surface are increased. In order to achieve the Rz=0.8 μm it is recommended to use a synthetic diamond micro-powder ASM20. Additionally, the influence of the contact pressure of the part onto the lap in the range from 25 to 150 kPa is investigated. With the increase of the contact pressure from 25 to 50 kPa, the total removal is significantly increasing whereas the relative diamond micro-powder consumption and surface roughness are essentially decreasing. Further increase of the contact pressure up to 150 kPa has smaller effect on the process parameters, while the cracks appear at the tool surface deteriorating the external view of the tool. The optimal contact pressure during finishing of the ceramic using the cast iron lap SCH-28 is about 50-100 kPa
Comparing the Analgesic Effects of Lidocaine and Lidocaine with Ketamine in Intravenous Regional Anesthesia on Postoperative Pain

Background and purpose: The main and the most known complication of intravenous regional anesthesia (IVRA) is systemic toxicity due to local anesthetics that occurs following the accidental tourniquet release immediately after injection. This study aims to evaluate the effect of adding ketamine to lower dose of lidocaine on reducing the dose and side effects of lidocaine. Materials and Methods: In this randomized clinical trial, 60 patients undergoing the surgery of upper limb below the elbow under IVRA were randomly divided into two groups. In group 1 (control group), 40 ml lidocaine 0.5% (200 mg) and in group 2 (intervention group), 40 ml lidocaine 0.25% (100 mg) plus 40 mg of ketamine 0.1% injected intravenously. Outcomes included postoperative pain at 15, 30 and 60 minutes after surgery. The pain of the patients was assessed by using the Visual Analogue Scale (VAS Score). Results: Both groups were comparable in demographic and surgical parameters. The average pain based on the VAS score at 15, 30 and 60 minutes after surgery was similar in both groups and there was no significant difference between the two groups (p> 0.05). Moreover, postoperative complications including unconsciousness, restlessness, dizziness, nausea, vomiting, tinnitus, seizure, delirium and hallucination had no significant differences (p> 0.05). Conclusion: Results of this study showed that the addition of ketamine to lower dose of lidocaine in patients receiving IVRA significantly reduced postoperative pain, and reduces the likelihood of systemic toxicity with lidocaine without causing significant adverse effects.
Single Photon Router in the Optical Regime Based on a Cavity Optomechanical System With a Bose–Einstein Condensate

We propose a novel scheme of a single photon router based on a coupled Bose-Einstein condensate cavity system. The numerical results obtained show that by controlling the route of the probe photon using an appropriate pump beam, this coupled system can serve as a single photon router. Importantly, this router works well in the optical regime, instead of the microwave regime, and at an ultralow pump power. The scheme, proposed here, may have potential applications in optical signal processing, communication, and quantum information networks.
Research on a wireless sensor network's modulation based on ultra wideband signals

This paper proposed a new wireless sensor network's modulation, multi-band OFDM modulation based on ultra wideband signals. The modulation used 7500(MHz) band from 3.1(GHz) to 10.6(GHz). The band was divided into thirteen same sub-bands. Each sub-band used OFDM modulation for transmission. The transmission node could adaptively choose one or more sub-bands to avoid interference according to reception node's feedback about interference sub-bands. The simulation results show that the modulation provides a good robust interference and coexistence performance. It also has low transmission power, low reception power, high-speed transmission, large system capacity and strong anti-multipath. So it is a cost-effective way to be integrated in the WSN instead of traditional radio transceiver. The modulation has good application prospect.