Miracle-dz/UniFAR-FTUs huggingface dataset:
Can Playfulness Be Designed? Understanding Playful Design through Agency in Astroneer (2019)

The cultural phenomenon that Minecraft (Mojang 2009) has become over the past decade demonstrates, amongst many other things, a powerful appetite for games where the player is thrown in a virtual playground to do as they please. Aerospace-themed survival-crafting game Astroneer (2019) by System Era Softworks is one of many such video games released since that capitalizes on this trend. The appeal of such games lies in that they can be enjoyed by players with various interests, abilities and backgrounds: the average player can mine, build, and fight whatever and whomever they please, or even create entire games within the game. The design of such games is, in many ways, less constricted than that of other avatar-based genres, such as action-adventures or first-person shooters. Freedom, playfulness, and creative play are often associated with such design, which evoke questions about agency. This article connects these notions and asks: can agency help us better understand how playfulness can be designed? By interrogating the paratexts surrounding the game’s development to see how developers discussed design decisions that facilitate playfulness, this article illustrates how thinking of agency as something afforded by game design can be a productive analytical tool to identify design decisions that facilitate player freedom and creative thinking. This, in turn, sheds light on whether, and if so how, playfulness can be designed.
EGBM: an ensemble gradient boost machine for lost circulation prediction

Lost circulation is one of the common drilling accidents. Occurrence of such problem will lead to a lot of wastage of resources. This paper proposes research on the application of ensemble gradient boost decision tree (GBDT) to develop a robust model that can be used to predict the occurrence of lost circulation precisely. In the first step, we collect 1048550 wells drilling data from northwest of China. Then two artificial features, distance feature and aggregation feature, are constructed by visualization. Next, we use three GBDT algorithms, XGBoost, LightGBM and Catboost, to build prediction models. Finally, we take the mean and maximum probability, predicted by the above three algorithms, as the ultimate output result. The result of the analysis has revealed that the ensemble model we propose performance are better than a single model. Besides, the model incorporates artificial features can attain a higher predicting accuracy.
Methionine Sulfoxide Reductase A in Human and Mouse Tissues is Responsible for Sulindac Activation, Making a Larger Contribution than the Gut Microbiota

Sulindac is a nonsteroidal anti-inflammatory prodrug that is converted to its pharmacologically active metabolite, sulindac sulfide, via a reduction reaction. It is widely accepted that the gut microbiota is responsible for sulindac activation; however, sulindac-induced gastrointestinal injury, which is caused by irritation of the gastrointestinal tract by its active metabolite, is uncommon. Therefore, it is surmised that sulindac is converted to its active metabolite in tissues after absorption. In this study, we sought to identify the enzyme(s) responsible for sulindac activation in tissues and to compare its/their contribution to the gut microbiota. Sulindac is enzymatically reduced in human intestinal, liver, and renal cytosols. Since sulindac is known to be reduced by methionine sulfoxide reductase (Msr) in Escherichia coli, we investigated whether the human ortholog MSRA catalyzes the sulindac reduction reaction. We found that recombinant human MSRA shows sulindac reductase activity with a similar Michaelis constant value as tissue cytosols. In addition, it was revealed that cytosolic factor(s) efficiently enhanced MSRA activity. By using the relative expression factor, the contribution of MSRA to the sulindac reductase activities in each tissue cytosol was calculated to be almost 100%. In mice, depletion of the gut microbiota by administration of antibiotics resulted in a 31% decrease in the area under the curve ratio of sulindac sulfide to sulindac, indicating that the contribution of tissue MsrA to sulindac activation is expected to be 69% in the body. In conclusion, we demonstrated that MSRA expressed in tissues is involved in sulindac activation, making a larger contribution than the gut microbiota. SIGNIFICANCE STATEMENT Methionine sulfoxide reductase A is responsible for the activation of sulindac, a nonsteroidal anti-inflammatory prodrug, to sulindac sulfide, an active form, in human tissues. Methionine sulfoxide reductase A expressed in tissues activates sulindac with a higher contribution than gut microbiota in body.
Spoofing Attacks on FMCW Radars with Low-Cost Backscatter Tags

This work studies the feasibility of using backscatter-modulated tags to introduce false information into a signal received by a frequency-modulated continuous-wave (FMCW) radar. A proof-of-concept spoofing device was designed in the 24 GHz ISM band. The spoofing device was based on an amplifier connected between two antennas, and modulation was carried out by switching the amplifier bias. The use of an amplifier allowed us to increase the level of spoofing signal compared with other modulated backscattering methods. The simulated and experimental results show that our method has the ability to generate a pair of false targets at different ranges and velocities depending on the modulation frequency of the chosen tag, since sidebands appear due to this modulation. Countermeasures to detect the spoofing attack based on changes in the slope of the frequency sweep between frames are also proposed.
Acupuncture with or without acupoint application for primary dysmenorrhea: protocol for a systematic review and meta-analysis

Introduction Dysmenorrhea is the most common gynaecological symptom reported by women. Ninety percent of women presenting for primary care experience some menstrual pain. Population surveys suggest that, although prevalence rates vary considerably by geographical location, complaints of dysmenorrhea are widespread in diverse populations. This study will evaluate the results of randomized controlled trials to determine the efficacy and safety of acupuncture with or without acupoint application for the treatment of dysmenorrhea. Methods Eight databases, including China National Knowledge Infrastructure, Chinese Scientific Journal Database, Cochrane Central Register of Controlled Trials, Embase, MEDLINE, PubMed, Wanfang Database, and Web of Science, will be searched using English and Chinese search strategies. In addition, manual retrieval of research papers, conference papers, ongoing experiments, and internal reports, among others, will supplement electronic retrieval. All eligible studies published on or before December 12, 2021 will be selected. To enhance the effectiveness of the study, only clinical randomized controlled trials related to the use of acupuncture with or without acupoint application for the treatment of dysmenorrhea will be included. Analysis The Visual Analog Scale will be the primary outcome measure, whereas the McGill pain questionnaire, SF-36 Scale, Self-Rating Anxiety, and Self-Rating Depression scale will be the secondary outcomes. Side effects and adverse events will be included as safety evaluations. To ensure the quality of the systematic evaluation, study selection, data extraction, and quality assessment will be independently performed by two authors, and a third author will resolve any disagreement. Ethics and dissemination This systematic review will evaluate the efficacy and safety of acupuncture with or without acupoint application for the treatment of dysmenorrhea. Since all included data will be obtained from published articles, it does not require ethical approval and will be published in a peer-reviewed journal. INPLASY registration number: INPLASY202230051.
Structure topology optimization based design of tank support system of tunnel continuous washer

In order to optimize the structure of tank support system of tunnel continuous washer, the 3D model was established by Pro/E and was imported to HyperMesh, then finite element static analysis and topology optimization analysis have been carried out. The optimum results showed that the weight of tank support system reduced by 39.27%, the stiffness and strength can completely satisfy the needs of the design.
Towards sustainable supply strategy in the food industry: the case of Finland

PurposeThis paper investigates how sustainability requirements modify supply strategies at different levels in the food industry companies. The paper integrates single supply decisions into firm-level supply strategy and views supply strategy as one coherent strategy in which the decision-making is based on the values and principles of a firm.Design/methodology/approachThe paper captures the decade of change and studies the renewal of supply strategy by utilising two qualitative data sets with a ten years of difference. The data contain 41 interviews from a retailer and 5 of its food supplier companies.FindingsResults confirm that a decade ago only minor attention was channelled towards sustainability whereas today sustainability is a key driver behind supply decisions and supply strategies because firms need to respond to sustainability requirements and challenges. The study presents a framework for analysing different levels (firm, category and supply market levels) of changes and sustainability requirements faced by food companies and their supply strategies.Originality/valuePreviously, sustainability has rarely been connected to firm-level supply strategy. This study presents the supply strategy elements that were important for Finnish food industry companies over a decade ago and matches these elements to the needs of today’s firms. As a result, the study incorporates the concept of sustainability with the supply strategy frameworks.
Prognostic significance of long noncoding RNA HOTAIR in hepatocellular carcinoma: A protocol for systematic review and meta-analysis

Background: Homeobox transcript antisense intergenic RNA (HOTAIR), a long noncoding RNA, has been reported to associate with the prognosis of patients with hepatocellular carcinoma (HCC) in several studies, however, the definite conclusion has not been obtained for conflicting results across different studies. The aim of this study is to determine the association of HOTAIR expression with overall survival, progression-free survival, and clinical features in HCC. Methods: PubMed, Cochrane Library, and Embase will be comprehensively searched to seek the relevant studies. The studies meeting the inclusion criteria will be included into this systematic review and meta-analysis. A combination of hazard ratio and 95% confidence interval is used to estimate the impact of HOTAIR expression on the overall survival and progression-free survival in HCC. The relationship between HOTAIR expression and clinical features of HCC is evaluated using the odds ratio and 95% confidence interval. The study quality is evaluated with the “risk of bias assessment” tool in Cochrane System Assessment Manual or Newcastle-Ottawa Scale. The subgroup analysis, publication bias, and sensitivity analysis are performed. Results: This study provides a strict and classic protocol for systematic review and meta-analysis to determine the prognostic significance of HOTAIR expression in HCC. The findings of this systematic review and meta-analysis may provide a novel diagnostic indicator and potential therapeutic target of HCC. Ethics and dissemination: This study is only a protocol for systematic review and meta-analysis, and all data used in this study is acquired through published studies. Therefore, the ethical review is not needed for this study. Registration number: INPLASY202230050.
The Prevalence of Pulmonary Embolism in Patients With Interstitial Lung Disease: A Cross-Sectional Retrospective Study

Objective: Interstitial lung disease (ILD) can be complicated by comorbidities, particularly pulmonary embolism (PE). We aimed to assess the prevalence of PE in ILD patients. Methods: Our study is a cross-sectional retrospective study conducted on ILD cases diagnosed between January 1, 2010, and June 30, 2021. Out of the total ILD cases (n = 153), we enrolled for analysis only those who underwent a computed tomography pulmonary angiography (CTPA) (n = 48). We recorded the number of patients who had a PE event on CTPA, gender, age at PE and ILD diagnoses, a chronology of PE with ILD diagnosis, PE characteristics, PE therapy, type of ILD, radiographic progression of ILD, presence of pulmonary hypertension, and mortality. Results: Seven patients out of 48, had PE (14.6%). The mean age at the time of PE diagnosis was 70 ± 9.73 years. No statistical difference existed between the PE and non-PE groups regarding gender predominance or the age at ILD diagnosis. All of the identified PE events (n = 7) were segmental (100%), one was saddle PE (14.3%) and one was recurrent (14.3%). No PE events were diagnosed prior to ILD diagnosis, three patients (42.9%) had a simultaneous diagnosis of PE and ILD, and four patients (57.1%) were diagnosed with a PE after ILD diagnosis by a mean time of eight months. No difference in ILD radiographic progression, pulmonary hypertension, or mortality between the two groups was found. Conclusion: PE is not uncommon in ILD and needs to be ruled out, especially in patients with worsening respiratory status.
The NOP14 nucleolar protein suppresses the function and stemness of melanoma stem-like cells through Wnt/beta-catenin signaling inactivation

ABSTRACT Cancer stem cells (CSCs) are closely related to tumor occurrence, development, metastasis, drug resistance, and recurrence. The role of CSCs in melanoma is poorly understood. Our previous studies suggested that the NOP14 nucleolar protein (NOP14) is involved in melanoma pathogenesis regulation. Importantly, NOP14 overexpression inhibits the Wnt/beta (β)-catenin signaling pathway, an important mechanism regulating CSCs stemness. Therefore, in this study, we aimed to explore the role of NOP14 in the stemness and function of CSCs in melanoma in vitro. CD133, a stem cell marker, was used to identify melanoma stem-like cells (SLCs). NOP14 overexpression subsequently decreased the proportion of CD133+ SLCs, impaired the colony-forming capabilities, and downregulated the expression of Nanog, SOX2, and OCT4 stem cell markers in A375 and A875 cells, suggesting that NOP14 suppresses the stemness of melanoma SLCs. NOP14 overexpression suppressed the migration, invasion, and angiogenesis-inducing ability of A375-SLCs and A875-SLCs. NOP14 overexpression also inactivated Wnt/β-catenin signaling in melanoma CD133+ SLCs. The Wnt signaling activator BML-284 alleviated the effect of NOP14 overexpression on the stemness and function of melanoma CSCs. In conclusion, NOP14 suppresses the stemness and function of melanoma SLCs by inactivating Wnt/β-catenin signaling. Thus, NOP14 is a novel target for CSC treatment in melanoma. Abbreviations: CSCs, cancer stem cells; SLCs, stem-like cells; NOP14, NOP14 nucleolar protein; SCID, severe combined immunodeficiency; β-catenin, beta-catenin; lv-NOP14, lentivirals expressing NOP14; PBS, phosphate buffer saline; HUVECs, human umbilical vein endothelial cells.
Available and affordable complementary treatments for COVID‐19: From hypothesis to pilot studies and the need for implementation

Abstract Vaccination is a highly effective preventive measure against COVID‐19. However, complementary treatments are needed to better control the disease. Fermented vegetables and spices, agonists of the antioxidant transcription factor nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2) and TRPA1/V1 channels (Transient Receptor Potential Ankyrin 1 and Vanillin 1), may help in the control of COVID‐19. Some preliminary clinical trials suggest that curcumin (spice) can prevent some of the COVID‐19 symptoms. Before any conclusion can be drawn and these treatments recommended for COVID‐19, the data warrant confirmation. In particular, the benefits of the foods need to be assessed in more patients, through research studies and large trials employing a double‐blind, placebo‐controlled design.
The Aging Process of Cadmium in Paddy Soils under Intermittent Irrigation with Acid Water: A Short-Term Simulation Experiment

Cadmium (Cd)-contaminated paddy soils are a big concern. However, the effect of irrigation with acid water on the migration and transformation of Cd and the effect of alternating redox conditions caused by intermittent irrigation on Cd aging processes in different depths of paddy soils are unclear. This study revealed Cd fractionation and aging in a Cd-contaminated paddy soil under four irrigation periods with acid water and four drainage periods, by applying a soil columns experiment and a sequential extraction procedure. The results showed that the dynamic changes of soil pH, oxidation reduction potential (ORP), iron (Fe) oxides and dissolved organic carbon (DOC) throughout the intermittent irrigation affected the transformation of Cd fractions. After 32 days, the proportion of exchangeable Cd (F1) to the total Cd decreased with a reduction of 24.4% and 20.1% at the topsoil and the subsoil, respectively. The labile fractions of Cd decreased, and the more immobilizable fractions of Cd increased in the different depths of soils due to the aging process. Additionally, the redistribution of the Fe and Mn oxide-bound Cd (F3) and organic matter and secondary-sulfide-bound Cd (F4) occurred at different depths of soils during the incubation time. Overall, the bioaccessibility of Cd in the subsoil was higher than that in the topsoil, which was likely due to the leaching and accumulation of soluble Cd in the deep soil. In addition, the aging processes in different depths of soils were divided into three stages, which can be mainly described as the transformation of F1 into F3 and F4.
Construction of Al-Mg-Zn Interatomic Potential and the Prediction of Favored Glass Formation Compositions and Associated Driving Forces

An interatomic potential is constructed for the ternary Al-Mg-Zn system under a proposed modified tight-binding scheme, and it is verified to be realistic. Applying this ternary potential, atomistic simulations predict an intrinsic glass formation region in the composition triangle, within which the glassy alloys are more energetically favored in comparison with their solid solution counterparts. Kinetically, the amorphization driving force of each disordered state is derived to correlate the readiness of its glass-forming ability in practice; thus, an optimal stoichiometry region is pinpointed around Al35Mg35Zn30. Furthermore, by monitoring the structural evolution for various (Al50Mg50)1−xZnx (x = 30, 50, and 70 at.%) compositions, the optimized-glass-former Al35Mg35Zn30 is characterized by both the highest degree of icosahedral ordering and the highest phase stability among the investigated compositions. In addition, the icosahedral network in Al35Mg35Zn30 exhibits a much higher cross-linking degree than that in Al25Mg25Zn50. This suggests that there is a certain correlation between the icosahedral ordering and the larger glass-forming ability of Al35Mg35Zn30. Our results have significant implications in clarifying glass formation and hierarchical atomic structures, and in designing new ternary Al-Mg-Zn glassy alloys with high GFA.
Trailing Edge Flap Effects on Dynamic Stall Vortex and Unsteady Aerodynamic Forces on a Pitching Airfoil

This study focuses on the effect of the upward deflection of trailing edge flap (TEF) on the strength and trajectory of dynamic stall vortex (DSV) around a pitching airfoil by means of numerical simulations based on unsteady Reynolds-averaged Navier-Stokes (URANS). The effect of the upward deflection of the TEF on the unsteady aerodynamic forces due to DSV is analyzed. The numerical simulation method for large mesh deformation is constructed. Radial basis function- (RBF-) based mesh deformation algorithm, as well as Laplacian and optimization-based mesh smoothing algorithm, is adopted to ensure the mesh quality in flow field simulations. The results reveal that the upward deflection of the TEF can reduce the peaks of drag and pitching moment coefficients. Although the maximum lift coefficient of the airfoil is slightly reduced, its maximum drag and pitching moment coefficients are significantly reduced by up to 34.8% and 31.8%, respectively. The vorticity transport behavior in a planar control region during the DSV formation and detachment is analyzed. It is found that the TEF can change the development process of the DSV. The upward deflection of the TEF reduces the vorticity flux from the leading edge shear layer, which causes the circulation of the DSV and the translational velocity of the vortex center to decline. The peaks of the unsteady aerodynamic forces on the airfoil induced by the DSV are reduced. The upward deflection of the TEF plays the role of alleviating the pitching moment load. The longer TEF can result in a better control effect. The bigger the upward deflection angle of the TEF, the better its control effect.
Aircraft Fuel Volume Characteristic Calculations and Multi-Sensor Technology on Fuel Volume Measurement Simulation

Owing to the reasons of aircraft attitude error and fuel surface sloshing, the current measurement methods which use the height value of fuel sensor, flight attitude angle and aircraft acceleration information to determine the position of the fuel surface and calculate the fuel volume are inaccurate. This paper applies CATIA secondary development to automatically establish the volume characteristic database which includes various fuel surface angles and height of fuel sensors; A plurality of fuel sensors are arranged reasonably in the fuel tank to ensure that there are at least three sensors immersed in the fuel in each attitude angle, then the fuel surface is determined directly by the measured height of several fuel sensors, and fuel surface parameters are put into a simulation software as input parameters which are designed to measure the fuel volume and calculate the fuel volume in the fuel tank by interpolating. Besides, rotation test platform is designed for aircraft fuel tank with two degrees of freedom to simulate aircraft fuel measurement process. The experimental data can verify the accuracy of multi-sensor fuel measurement system.
Discussion on the quality control of variable cross-section box-girder cradle construction

Combining with the main bridge variable cross-section boxgirder cradle construction of super large bridge in Hanjiang,the construction quality control of prestressed concrete continuous rigid frame variable cross-section box-girder bridge was discussed from the quality requirement of cradle,the quality control of cast-in-place concrete and the treatment of quality problems in construction,which can provide guide for similar engineering construction.