Miracle-dz/UniFAR-FTUs huggingface dataset:
Health-related quality of life and psychological functioning in patients with primary malignant brain tumors: a systematic review of clinical, demographic and mental health factors.

Background The impact of primary malignant brain tumors on patient quality of life and psychological functioning is poorly understood, limiting the development of an evidence base for supportive interventions. We conducted a thorough systematic review and quality appraisal of the relevant literature to identify correlates of health-related quality of life (HRQoL) and psychological functioning (depression, anxiety and distress) in adults with primary malignant brain tumors. Method Twenty-three articles met predefined inclusion criteria from a pool of peer-reviewed literature published between January 1984 and July 2015 (N = 2407). Methodological quality of included studies was assessed using an adapted version of the Newcastle-Ottawa Scale. Results The overall methodological quality of the literature was moderate. Factors relating consistently with HRQoL and/or psychological functioning were cognitive impairment, corticosteroid use, current or previous mental health difficulties, fatigue, functional impairment, performance status and motor impairment. Conclusions Practitioners should remain alert to the presence of these factors as they may indicate patients at greater risk of poor HRQoL and psychological functioning. Attention should be directed towards improving patients' psychological functioning and maximizing functional independence to promote HRQoL. We outline several areas of future research with emphasis on improved methodological rigor.
Journal of Cerebral Blood Flow & Metabolism Volume 21, 2001: Author Index

Badaut J, 477 Bareyre FM, 396 Barone FC, 755 Bartels M, 361 Bates S, 755 Battaglia G, 1013 Baughman VL, 907 Beech JS, 683 Beer R, 1281 Behar KL, 585 Benndorf G, 1067 Bennet L, 493 Beray V, 15 Bergeron M, 1105 Bernardes-Silva M, 1115 Berry M, 157 Bieneman A, 972 Bleys RLAW, 149 Blomqvist G, 114 Boado RJ, 61, 929 Boas DA, 195 Boesch C, 276 Bogousslavsky J, 477 Bohme GA, 15 Bolay H, 195 Bonvento G, 404 Booth AM, 285 Bottlaender M, 613, 782, 1493 Boulanouar K, 592, 1330 Bowen KK, 945 Boyd CD, 568 Bozigian H, 1208 Bozzali M, 85 Bramlett HM, 847 Brant CL, 285 Brawner M, 755 Bresolin N, 85 Broft A, 1034 Brown AM, 385 Brown P, 483 Brucklacher RM, 52 Bruno V, 1013 Bryan RM Jr, 77 Büchel C, 1171 Buisson A, 820 Burguete MC, 422, 1097 Busto R, 865, 1401 Butch ER, 132
Dual immuno-regulatory effects of Y-40138 in animal models of sepsis and aspiration pneumonitis

We evaluated the dual immuno-regulatory effects of Y-40138, inhibiting tumor necrosis factor (TNF)-α production and augmenting interleukin (IL)-10 productions, in animal models of organ dysfunction related to systemic inflammatory response syndrome. Male Sprague-Dawley rats received Y-40138 (1, 10 and 30 mg/kg) or saline subcutaneously, and were subjected to cecal ligation and puncture (CLP) surgery 15 min later. Male C57Bl/6 mice received Y-40138 (30 mg/kg) or saline intravenously and were subjected to intratracheal instillation of hydrochloric acid (0.1 N, pH = 1.0) 30 min later. Survival after CLP surgery was monitored for 10 days and compared by Kaplan-Meier analysis and log rank statistics. Neutrophil count and cytokine concentrations in bronchoalveolar lavage (BAL) fluid at 12 h after intratracheal instillation were analyzed by one-way ANOVA. After CLP surgery, while 1 mg/kg of Y-40138 increased survival, 30 mg/kg of Y-40138 decreased survival (p < 0.01). After acid aspiration, Y-40138 significantly inhibited neutrophil recruitment by decreasing TNF-α / IL-10 ratio in BAL fluid (p < 0.05). Although the down regulation of pro-inflammatory cytokines and augmentation of anti-inflammatory cytokines seems a rational approach for SIRS-related multiple organ failure, further studies are needed for future clinical application of Y-40138, especially in situations compromised with microorganisms infection. 5.0 computer program (Abacus Concepts, Berkeley, CA). Analyses were performed by one-way factorial analysis of variance, followed by Fisher’s least significant differences test. A p value of less than 0.05 considered indicating a statistically significant difference.
Tomography of the Temporal Bone with the Polytome

Roentgen examination of the temporal bone has for many years been of importance in the diagnosis of acute and chronic inflammation. The bone is, however, usually markedly thickened in the latter condition and it is difficult to demonstrate the fine structural detail in the many elaborate projections required in ordinary roentgenography. I therefore now prefer tomography as the routine method of examination. Twenty to thirty investigations of tomography of the temporal bone have been published since 1932. ZIEDSES DES PLANTES (1932) and BARTELINK (1933) employed a curvilinear tomograph in a few cases. Linear tomography, however, has been used by most investigators, including MUNTEAN and FINK (1941) and ZI.MMER (1952), who examined the largest series on record. LEMAHIEU (1952) thoroughly investigated the advantages of tomography as compared with the classical methods of examination. Based upon STIEVE'S theoretical studies, FREY (1956) used the polytome in investigations of preparations of the normal temporal bone and drew up a table in which its normal details were given. For theoretical reasons, it must be expected that curvilinear tomography, i. e. tomography with circular or similar symmetrical movements,
Internet Appendix to “Corporate Governance, Product Market Competition, and Equity Prices” XAVIER GIROUD and HOLGER M. MUELLER Index

Table IA.I: Empirical Relation between the G-index and the HHI Table IA.II: Replication of Gompers, Ishii, and Metrick (2003) Table IA.III: Firmvs. Industry-level HHI Cutoffs & HHI Terciles vs. Quartiles Table IA.IV: Industryand Characteristics-adjusted Returns Table IA.V: Analysts’ Forecast Errors: Robustness Table IA.VI: Tobin’s Q: Robustness Table IA.VII: Cross-sectional Regressions of Tobin’s Q Table IA.VIII: Return on Assets (ROA): Robustness Table IA.IX: Net Profit Margin (NPM): Robustness Table IA.X: Sales Growth: Robustness Table IA.XI: Return on Equity (ROE): Robustness
Author's Reply

Ichise M, Ballinger JR, Golan H, Vines D, Luong A, Tsai S, Kung HF (1995) SPECT imaging of dopamine D2 receptors in humans with iodine 123-IBF: a practical approach to quantification not requiring blood sampling. J Nucl Med 36: llP Logan J, Fowler JS, Volkow ND, Wolf AP, Dewey AL, Schlyer OJ, MacGregor RR, Hitzeman R, Bendiriem B, Gatley SJ, Cristman DR (1990) Graphical analysis of reversible radio li­ gand binding from time-activity measurements applied to [N-llC-methyl]-( )-cocaine PET studies in human subjects. J Cereb Blood Flow Metab 10:740-747
Iohexol Clearance for Renal Function Measurement in Gynaecologic Cancer Patients

Purpose: To determine a valid and practical routine for glomerular filtration rate measurement in gynaecologic cancer patients. Material and Methods: The established method, endogenous creatinine clearance, was compared to 51Cr-EDTA clearance and contrast medium clearance in 68 women with various gynaecologic carcinomas. Contrast medium clearance was determined in association with conventional urography (iohexol 300 mg I/ml, 40 ml) for evaluation of urinary tract involvement by the tumour. Automated X-ray fluorescence analysis equipment was used for the plasma analysis of iohexol and clearance calculations. Endogenous creatinine clearance and 51Cr-EDTA clearance were determined according to standard routine procedures. Simultaneous determinations of contrast medium clearance and 51Cr-EDTA clearance (n=33), contrast medium clearance and endogenous creatinine clearance (n=50), as well as 51Cr-EDTA clearance and endogenous creatinine clearance (n=30) were compared. Results and Conclusion: The mean differences were −2.8 (SD 6.6), −1.8 (SD 22.3), and 2.7 (SD 18.3) ml/min/1.73 m2, respectively. It is concluded that contrast medium clearance is as adequate as 51Cr-EDTA clearance for glomerular filtration rate measurement. We suggest that contrast medium clearance should replace endogenous creatinine clearance, especially in patients referred for urography.
Ethanolic Leaf Extract of Croton Z a mbesicus (MÜll. Arg.) Improves Gastric Emptying Capacity and Gastric Mucosa Integrity in Streptozotocin-induced Diabetic Rats

The aim of this study was to examine the effect of C. zambesicus leaf ext ract on the gastric emptying capacity, histomorphometry, nitric o xide (NO) and prostaglandin E2 (PGE2) levels in experimentally induced diabetic wistar rats. At the end of the experimental period, the animals were sacrificed and the stomach excised for gastric emptying analysis. Tissues were later processed and stained for histomorphometric analysis. Seru m was obtained for NO and PGE2 analysis using respective research kits. The results showed that the percentage gastric emptying capacity were significantly increased (P<0.05) in group pretreated with C. zambesicus (78.40 ± 2.99%) and group treated with C. za mbesicus for four weeks (72.80 ± 5.82%) when compared with the untreated diabetic group (39.20 ± 6.15% ). NO and PGE2 were significantly reduced (p<0.05) in the untreated diabetic rats when compared with extract treated groups. Also, there was a significant (p<0.05) improvement in the histomorphometry of the extract treated groups as compared with the untreated diabetic group. In conclusion, this study had shown that C. zambesicus extract has a positive influence on gastric emptying capacity and gastric mucosa integrity in d iabetic rats.
De Quervain’s syndrome: It may not be an isolated pathology

Introduction This paper details a retrospective review of patients’ records diagnosed with de Quervain’s syndrome following a traumatic event but no history of repetitive strain. Methods Data analysis of 41 patients was performed. The inclusion criteria were pain over first dorsal compartment, pain on resisted extensor pollicis brevis and/or abductor pollicis longus, and a positive Finkelstein’s test. The assessment included a subjective history to establish a repetitive activity or a traumatic incident and diagnostic tests to establish possible instability or osteoarthritis. Results There were 13 men and 28 women with an age range from 20 to 72 years. Statistical analysis was undertaken using Fisher’s Exact tests. 46.3% (n = 19) of 41 patients had a ligament injury diagnosed after the de Quervain’s. 94.7% (n = 18) of 19 patients with ligament instability had a history of trauma, and this was statistically significant. Clinically significant was that 82.9% (n = 34) of 41 patients demonstrated extensor carpi ulnaris (ECU) muscle weakness, but there was no statistical significant correlation between ECU weakness and ligament instability. Patients could have ECU weakness without ligament instability; however, patients with ligament instability appeared more likely to have ECU weakness. Conclusions The results would suggest that de Quervain’s syndrome, in a proportion of patients, could be secondary to underlying wrist pathology due to previous trauma. If the patient does not report a true repetitive strain history, a more thorough assessment may need to be undertaken to establish if there is any underlying pathology.
Role of Promoter C-480T Polymorphism of Hepatic Lipase in the Development of Atherosclerosis

10 INTRODUCTION 11 REVIEW OF THE LITERATURE 13 1 Atherosclerosis 13 1.1 Normal structure of arteries 13 1.2 Classification of atherosclerotic lesions 14 1.3 Development of atherosclerosis 17 1.3.1 Development of early atherosclerotic lesions 17 1.3.2 Development of advanced atherosclerotic lesions and thrombosis 18 1.3.3 Main hypotheses for the development of atherosclerosis 19 2 Overview on general lipoprotein metabolism 21 2.1 Lipids and lipoproteins 21 2.2 Plasma apolipoproteins 22 2.3 Lipoprotein metabolism and lipid risk factors for atherosclerosis 23 2.3.1 Exogenous pathway 24 2.3.2 Endogenous pathway 24 2.3.3 Reverse cholesterol transport (RCT) 25 2.3.4 Lipid risk factors for atherosclerosis and selection of hepatic lipase gene.28 3 Hepatic lipase (HL) 30 3.1 Lipase super family 30 3.2 Synthesis, structure and function of HL 31 3.3 Measurement of HL activity and HL mass concentration 31 3.4 HL in lipid metabolism 32 3.4. 1 HL, HDL metabolism and RCT 34 3.4. 2 HL and apolipoprotein B-containing lipoprotein metabolism 34 3.5 HL deficiency 35 4 HL gene (LIPC) 35
A Comparative Study of the Curriculum of Undergraduate Nursing Education in Iran and Selected Renowned Universities in the World

زمینه و هدف: برای موفقیت هرچه بیشتر رشته کارشناسی پرستاری در ایران و شناسایی نقاط قوت و ضعف برنامه درسی آن، پرداختن به مطالعات تطبیقی و بهره‌برداری از تجارب و راهبردهای تجربه شده در دانشگاه‌های موفق، امری ضروری است. پژوهش حاضر به صورت مطالعه تطبیقی به بررسی ساختار برنامه درسی دوره کارشناسی پرستاری در ایران با برخی از دانشکده‌های منتخب از قاره‌های آمریکا، اروپا، اقیانوسیه و آسیا پرداخت و در طی آن روش‌های گزینش دانشجو، رسالت و اهداف، ساختار کلی و طول دوره و محتوای آموزشی دوره، روش‌های یاددهی و یادگیری و استراتژی‌های آموزشی مورد استفاده، نقش دانش آموختگان این رشته و روش‌های ارزشیابی مورد استفاده در برنامه درسی ایران و دانشکده‌های منتخب را مقایسه نمود. روش کار: در این پژوهش توصیفی- تطبیقی (مقایسه‌ای)، عناصر اصلی و شاخص‌های مهم برنامه درسی 8 دانشکده پرستاری معتبر و پیشگام در آموزش پرستاری از قاره‌های آمریکا، اروپا، اقیانوسیه و آسیا که به صورت هدفمند انتخاب شده بودند، مورد بررسی و تجزیه و تحلیل قرار گرفت. سپس، هر یک از موارد بررسی شده، در دانشکده‌های مورد مطالعه و ایران مقایسه گردید و پیشنهادهای کاربردی برای بهبود بخشیدن به وضعیت برنامه آموزشی دوره کارشناسی پرستاری ایران از نظر بهبود بخشیدن به وضعیت هر یک از عناصر ارایه شد. الگوی مورد استفاده الگوی Beredy بود که چهار مرحله توصیف، تفسیر، همجواری و مقایسه را در مطالعات تطبیقی مشخص کرد. یافته‌ها: بر اساس یافته‌های پژوهش، اهداف کلی و محتواهای آموزشی در تمامی برنامه‌‌های مورد مطالعه تا حدودی مشابه، اما سازماندهی و تدوین محتواها از یک طرف و نحوه، میزان و نوع پرداختن به آن‌ها متفاوت بود و در نتیجه، محتواهای متفاوتی را ایجاد نمود. همچنین، با وجود شباهت‌های بسیار در تکنیک‌های مورد استفاده در تدریس و ارزشیابی، تفاوت‌های بسیاری نیز بسته به سطح و اهداف برنامه ملاحظه شد. نتیجه‌گیری: به نظر می‌‌رسد اگرچه برنامه آموزشی ایران در مقایسه با برنامه‌های آموزشی مورد مطالعه از جایگاه بدی برخوردار نیست، اما به منظور رفع کاستی‌ها و نقایص آن، مواردی مانند انتخاب اهداف، گزینش دانشجو، پژوهش، روش‌های تدریس و ارزشیابی تئوری و عملکرد باید مورد بازبینی و اصلاحات جدی قرار گیرد.
Comparison between local anaesthetic agents, lidocaine and bupivacaine, in patients undergoing third molar extraction in terms of patient satisfaction.

Comparison between local anaesthetic agents, lidocaine and bupivacaine, in patients undergoing third molar extraction in terms of patient satisfaction. Author(s) McCarthy, Caroline Publication date 2016 Original citation McCarthy, C. 2016. Comparison between local anaesthetic agents, lidocaine and bupivacaine, in patients undergoing third molar extraction in terms of patient satisfaction. DClinDent Thesis, University College Cork. Type of publication Doctoral thesis Rights © 2016, Caroline McCarthy. http://creativecommons.org/licenses/by-nc-nd/3.0/
The Adaptation of the Implementation of Just In Time Method - A Case Study in Pharmacy of Kemang Medical Care

Introduction - The 30%-50% of the hospital’s income comes from pharmacy. The mishandling management can result in waste. If the drug excess, the hospital got loss, because the drugs will not be used. Unavailable drugs (stock out) can miss the chance to get a profit. Therefore, some efforts are made to manage the pharmacy, one of them: implementing JIT method. Some hospitals successfully implement these methods, including: Kemang Medical Care (Indonesia), Seattle Children's Hospital, Cincinnati Children's Hospital Medical Center, Sacre-Coeur Hospital in Montreal, and the Hospital for Sick Children (USA). Methodology - The study was conducted only in two hospitals (Kemang Medical Care and Seattle Children's Hospital). The information is gathered from the research reports from those hospitals. Interviews were conducted with those involved in the design, implementation, and monitoring. Questions related to how the JIT is designed, implemented, monitored, and the effects towards the pharmaceutical supplies.Results - Kemang Medical Care. Cost reduction is calculated from the ratio of purchases to sales. The ratio is increased from 4.39 becomes 8.04; since the purchases are dropped consistently, it is able to compensate the sales. Seattle Children's Hospital. The program takes 18 months and costs $200,000. The implementation of JIT is able to save 23,000 work hours per year and reduce the cost 5% of supply. The costs are equivalent with the ROI for amount $2.5 million in the first year and a profit of 1,200%. Discussion - The JIT method is more focused on the efforts to reduce the variation in the form of a good visual representation. JIT is a cost control method that eliminates the activity of continuous daily scheduling. Controlling is made easier with a good visual representation. Reduction of variation and visual representation are important in the implementation of JIT.
Attack Detection Using Federated Learning in Medical Cyber-Physical Systems

Medical Cyber-Physical Systems (MCPS) are networked systems of medical devices that provide seamless integration of physical and computation components in healthcare environments to deliver high quality care by enabling continuous monitoring and treatment. As MCPS store sensitive medical data and personal health data, security breaches and unauthorized access to this information can lead to severe repercussions for both the patient and hospital in the form of loss of privacy, abuse, physical harm and liability. The heterogeneity of devices involved in these systems (such as body sensor nodes and mobile devices) introduce large attack surfaces and hence necessitate the design of effective security solutions for these environments. In this paper, we design and implement a massively distributed, machine-learning-based intrusion detection solution for MCPS. Specifically, we explore the concept of Federated Learning to minimize the communication and computation costs involved in traditional machine learning based solutions. We evaluate our design with real patient data and against security attacks such as Denial of Service, data modification, and data injection. Experimental results illustrate that our system achieves high detection accuracy of 99.0% and a False Positive Rate of 1.0% along with a reduced network communication overhead. Lastly, we show that the system can cope with unevenly distributed data and is a scalable solution that leverages the computing resources of many mobile devices.
Epidermoid cyst of the intrapancreatic accessory spleen producing CA19‐9

We report a rare case of an epidermoid cyst in an accessory spleen at the pancreatic tail with producing CA19‐9. A 55‐year‐old female was admitted to our hospital, Cancer Research Institute, Kanazawa University, for close examination of a cystic lesion at the pancreatic tail and a high serum CA19‐9‐value (176 U/mL). There were almost no abdominal symptoms related to the cystic lesion. A cystic tumor approximately 3 cm in diameter and composed of multilocular cysts without a protruding portion of the inner surface was found at the pancreatic tail by ultrasound sonography, computed tomography, and magnetic resonance imaging. Endoscopic retrograde pancreatography revealed that the main pancreatic duct shifted at the pancreatic tail and there was no communication between the main pancreatic duct and cystic lesion. Based on a preoperative diagnosis of mucinous cystic tumor, distal pancreatectomy with splenectomy was performed. Histological ﬁndings suggested an epidermoid cyst (3.5 × 3.0 cm) originating from an intrapancreatic accessory spleen. Immunohistochemical analysis of CA19‐9 in the epidermoid cyst showed clear staining of the inner epithelium of the cyst and amorphous or hyalinous cystic contents. The serum CA19‐9 value was conﬁrmed to decline to normal 2 months after resection. Physicians should not forget this disease during differential diagnosis related to pancreatic cystic lesions with elevated levels of serum tumor markers, such as CA19‐9 or carcinoembryonic antigen, although this disease is extremely rare.
LATIN AMERICAN REMITTANCES DEPENDENCE ON EXTERNAL SHOCKS VACAFLORES,

Remittances have become an important and reliable source of funds for many developing countries, particularly Latin American countries. The inflow of remittances has been shown to improve consumption levels, health care access, educational attainment, and the implementation of entrepreneurial initiatives, affecting the economic prospects of the receiving countries. However, economic conditions in the host-countries have proven to be influential in immigrants’ earnings and their ability to send money to their families back home. This article measures the impact that economic fluctuations in the U.S. and Spain have in the amount of remittances received by 5 Latin American countries, showing that migrant workers tend to send more funds home when the state of the economy in which they reside improves. Our results also show that shocks to specific sectors of the host country produce a differential effect on the remittances flowing to different countries, both in terms of magnitude and sometimes direction.
Justifying All Differences Using Pseudo-Boolean Reasoning

Constraint programming solvers support rich global constraints and propagators, which make them both powerful and hard to debug. In the Boolean satisfiability community, proof-logging is the standard solution for generating trustworthy outputs, and this has become key to the social acceptability of computer-generated proofs. However, reusing this technology for constraint programming requires either much weaker propagation, or an impractical blowup in proof length. This paper demonstrates that simple, clean, and efficient proof logging is still possible for the all-different constraint, through pseudo-Boolean reasoning. We explain how such proofs can be expressed and verified mechanistically, describe an implementation, and discuss the broader implications for proof logging in constraint programming.
Integrating Biomechanical Manikins into a CAD Environment

This work investigates the opportunity to combine the best features of digital manikins and detailed musculoskeletal models. An interface between a makeshift digital manikin developed in SolidWorks and a detailed musculoskeletal model in the AnyBody Modeling System is developed. The interface reveals that the detailed musculoskeletal model solves some of the inherent problems in digital manikins and allows for a detailed analysis of the kinetics of the system, including the ergonomic influence of muscle and joint forces.
AMO | Advanced Modeling and Optimization, Volume 14, Number 2, 2012 CHARACTERIZATION OF SMARANDACHE M1M2 CURVES OF SPACELIKE BIHARMONIC B SLANT HELICES ACCORDING TO BISHOP FRAME IN E(1; 1)

In this paper, we nd parametric equations of SmarandacheM1M2 curves of spacelike biharmonic B slant helices according to Bishop frame in terms of Bishop curvatures in the Lorentzian group of rigid motions E(1; 1). Finally, we construct Bishop equations of SmarandacheM1M2 curves of spacelike biharmonic B slant helices in E(1; 1).