Miracle-dz/UniFAR-FTUs huggingface dataset:
RETROSPEC TIVE IDENTIFIC ATION OF GR ANULOMAS IN COLEC TOMY TISSUE IN PATIENTS PRE VIOUSLY DIAGNOSED WITH ULCER ATIVE COLITIS

Background and aims Infliximab is used as third-line treatment in sarcoidosis with mixed therapeutic efficacy. Therefore, it would be beneficial to establish markers that predict potential treatment success. Patients with sarcoidosis have reduced memory B cells and CD4 helper T-cell subsets compared to healthy controls. In this study, we evaluated cellular and serological immunological markers in sarcoidosis patients before and during infliximab therapy. Materials and Methods The therapeutic response to infliximab was clinically evaluated in all 11 patients along with serum levels of sIL-2R, IgG, BAFF, and infliximab trough levels. Furthermore, extensive flowcytometric analysis of blood B and T-cell subsets was performed of all 11 patients before and during infliximab therapy (2 and 6 weeks, 8 months). Results Nine (82%) patients showed an objective clinical response. sIL-2R levels rapidly declined after the first infliximab infusion, whereas serum IgG and BAFF levels did not alter. IgM+ memory B cell numbers increased in patients who clinically responded to infliximab therapy, as did the numbers of CD4, CD8 T cells, regulatory T cells, Th17 and Th17.1 T cells. Those who developed anti-drug antibodies (ADA), displayed lower levels of sIL2R and Tregs with higher IgM-only B cells at baseline than responders to infliximab. Most patient had infliximab levels within therapeutic range and at months these levels correlated significantly with sIL-2R levels. Conclusions Our study confirms the potential of monitoring infliximab trough levels, sIL-2R and ADA as promising markers for therapeutic success in sarcoidosis patients. Moreover, infliximab therapy normalizes IgM+ memory B cells and Th subsets, demonstrating cellular immune effects and the potential for new laboratory markers of therapy success.
Implantation : Flap and Subdural Lead Placement

Implanted electrodes used in reported studies have generally been Resume (Medtronic) or Lamitrode (ANS) stimulating strips, both quadripolar electrode arrays (each contact 5 mm in diameter; inter-contact distance center-to-center 1 cm); eightcontact paddles have been used in one failed trial(NCT00122915). Two strips can be positioned in parallel for wider coverage. The patient either lies down supine (Nguyen et al 1999, 2011) or in lateral decubitus (Park Bench) (Pirotte et al 2009) allowing horizontal orientation of the operative field and easy access to the contralateral limbs under the table.
Evolutionary Design of Combinational Circuits Based on an Embryo Circuit Module

This paper introduces a new design method of combinational circuits based on genetic programming (GP). An embryo circuit, which combines all evolvable functional cells together, is designed. Each evolvable cell is evolved separately which is the core of the embryo circuit and the whole circuit is designed after the cells evolutionary design finishes. GP is the evolutionary algorithms used to generate a satisfying circuit. The individuals of GP are represented by multi sub-tree groups in order to match the circuits' structures. Corresponding genetic operations are established, including improved crossover and mutation operators. In addition, the paper introduces a random individual set in order to improve the quality of a population. Finally the ability of this improved algorithm for finding optimal solution and its convergence speed are improved much. Final evolutionary results are structures of electronic circuits, which are easily understandable. The paper introduces a method of fitness evaluation based on true tables. The evolutionary results are inputted into MaxplusII10.2 to simulate their functions. In the experiment, two 2 bits ALU is designed, their simulation results shows the method is practicable and the designed circuits are independent on priori knowledge and their functions are satisfying. The comparison experiments proved the presented improved GP speeded up the convergence and improved the ability of GP for finding optimal solution.
A Simple Model of the Resonant Interaction between Vortex Rossby and Gravity Waves

A simple conceptual model of the resonant interaction in a typhoon-like vortex between vortex Rossby waves (VRWs) and gravity waves (GWs) that are caused by the VRWs is presented. It is well-known that the VRWs in the central region of the vortex can grow by the interaction with the GWs in the outer region, but a simple conceptual model for their interaction has not yet been proposed. The proposed conceptual model is based on the buoyancy-vorticity formulation (BV-thinking), and is different from that for the barotropic and baroclinic instabilities based on PV interactions (PV-thinking). We consider disturbances of the first baroclinic mode on a basic barotropic vortex. The disturbance vertical vorticity z of the VRW in the central region has a large amplitude on the upper and lower levels, whereas the disturbance buoyancy b and radial vorticity h of the GW have a large amplitude on the middle level. The central VRW propagates (relative to the fluid) anticyclonically, but moves cyclonically because of the strong cyclonic ad vection by the vortex. The outer cyclonically-propagating GW is also weakly advected cyclonically by the vortex. As a result, the counter-propagating VRW and GW (satisfying Rayleigh’s condition) may be phase-locked with each other (satisfying Fjørtoft’s condition). By the counter-propagation and phase-lock, the circulation around z of the VRW enhances b of the GW, which in turn enhances h . Simultaneously, the circulation around h of the GW enhances z of the VRW. As a result, the VRW and GW grow simultaneously. We analytically show the possibility of the resonant interaction, and numerically obtain the growing solution in the system linearized about the basic vortex.
Smartphone Application for Self-monitoring Dietary Intake (iDSA) among Cancer Patients

Objective: Evidence accumulates that optimal nutrition status positively influences cancer treatment outcomes. A “smartphone application” (intelligent dietitian support apps [iDSA]) was developed to act as a tool to assist patients in terms of dietary monitoring. This study aimed to examine the feasibility of iDSA for self-monitoring dietary intake among cancer patients. Materials and Methods: This was a pilot study. Eligible patients were approached and recruited. Dietitian entered individual estimated energy-protein requirement into iDSA after installation. Participants recorded and monitored own daily dietary intake. Dietitian arranged for a 2-week follow-up to monitor nutritional status (weight and dietary intake). Results : This study enrolled 14 participants, six males and eight females, with a mean age of 36.4 ± 10.1 years. iDSA improved participants’ nutritional outcomes significantly; weight gained 1.2 ± 0.2 kg, increased energy intake 215 ± 100 kcal/day, and protein intake 8 ± 5.1 g/day. There were 92.9% of participants agreed or totally agreed that they were able to monitor and increase dietary intake during using iDSA. However, about 57.1% reported that it was burdensome to record their diet daily and sometimes they forgot to record their food intake. Conclusion: Self-monitoring dietary intake through iDSA was feasible among cancer patients. The compliance of iDSA in self-monitoring dietary intake increased the dietary intake and body weight after 2-week. iDSA usability was rated good and can be used to study dietary intake among cancer patients.
Effects on Growth and Toxin Production of Exposure of Spores of Clostridium botulinum Type F to Sublethal Doses of Gamma Irradiation1

Spores of the Langeland strain of Clostridium botulinum type F were grown at 30 or 10 C after exposure to 0.0, 0.1, or 0.2 megarad of cesium-137 gamma irradiation. When incubated at 30 C, cultures irradiated at the 0.2-megarad level reached the stationary growth phase 15 hr earlier than the0.OorO. 1 megarad-irradiated cultures. This was not the result of earlier or more frequent germination of the irradiated spores, the formation of larger individual cells, filament formation, or cell clumping. It appeared to result from elimination of a lytic phenomenon noted in 0.0 and 0.1 megarad-irradiated cultures after 26 and 29 hr of incubation, respectively, which was followed by a second exponential-growth response 5 hr later in these cultures. The time of toxin appearance in culture supernatant fractions was independent of prior irradiation treatment and occurred after 36 hr of incubation. Toxin release was essentially logarithmic until maximaltiters were reached and maximal toxin titers were higher in irradiated than in unirradiated cultures. The higher toxin level was sus-tained over a period of 23 days at 30 C. Toxin produced in the 30 C cultures could not be trypsin-activated. An incubation temperature of 10 C resulted in no outgrowth of spores subjected to 0.2 megarad of irradiation, although spore germina- tion did occur. At 10 C, outgrowth of the 0.1-megarad culture was faster with slightly higher quantities of a more stable toxin than was seen in the unirradiated control. At 10 C, trypsinization was necessary to demonstrate the toxin present in the cultures.
Human Placental Leucine Aminopeptidase/Oxytocinase A NEW MEMBER OF TYPE II MEMBRANE-SPANNING ZINC METALLOPEPTIDASE FAMILY*

The serum level of placental leucine aminopeptidase (P-LAP) increases during pregnancy. P-LAP degrades several peptide hormones such as oxytocin and vaso- presin, suggesting a role in maintaining homeostasis during pregnancy. In the study reported here, we have isolated a cDNA clone with 4084 base pairs encoding P-LAP from a human placental cDNA library. The amino acid sequence deduced from the cDNA contained all of the sequences of the peptide fragments obtained by di- gestion of the purified protein with trypsin. The predicted P-LAP contains the HE XX H consensus sequence of zinc metallopeptidases, indicating that the enzyme belongs to this family, which includes aminopeptidase N and aminopeptidase A. The deduced sequence also contains a hydrophobic region near the N terminus, sug- gesting that the enzyme is a type II integral membrane protein. Northern blot analysis revealed that P-LAP was expressed in several tissues, some of which expressed two forms of mRNAs. These results suggest that the en- zyme is synthesized as an integral membrane protein and is released into blood under some physiological conditions. Aminopeptidases catalyze the cleavage of amino acids from the N terminus of protein or peptide substrates. They are widely distributed in animal tissues and found in many sub-cellular organelles, in cytoplasm, and as membrane compo-nents. They are shown to be essential for protein maturation, degradation of nonhormonal and hormonal peptides, and de-termination
비교기 기반 입력 전압범위 감지 회로를 이용한 6비트 500MS/s CMOS A/D 변환기 설계

A low power 6-bit flash ADC that uses an input voltage range detection algorithm is described. An input voltage level detector circuit has been designed to overcome the disadvantages of the flash ADC which consume most of the dynamic power dissipation due to comparators array. In this work, four digital input voltage range detectors are employed and each input voltage range detector generates the specific clock signal only if the input voltage falls between two adjacent reference voltages applied to the detector. The specific clock signal generated by the detector is applied to turn the corresponding latched comparators on and the rest of the comparators off. This ADC consumes 68.82mW with a single power supply of 1.2V and achieves 4.9 effective number of bits for input frequency up to 1MHz at 500 MS/s. Therefore it results in 4.75pJ/step of Figure of Merit (FoM). The chip is fabricated in 0.13-um CMOS process.
T hrough The L iminaL : a C omparaTive a naLysis of C ommuniTas and r iTes of p assage in s porT h azing and i niTiaTions

Hazing rituals and ceremonies have been described in traditional, historical world cultures, junior and high school, the military, private schools, paramilitary organizations, fraternities and sororities, as well as sport (Allan and Madden 2008; Bryshun and Young 1999; Campo, Poulos, and Sipple 2005; Fields, Collins, and Comstock 2010; Johnson 2000, 2009; Linhares de Albuquerque and Paes-Machado 2004; Nuwer 1999; Winslow 1999; Zacharda 2009). Student athletes often endure hazing practices with 80% of NCAA athletes reporting some form of initiation (Hoover 1999) in exchange for membership affiliation. This qualitative study compared the similarities and deviations between contemporary initiations and historical traditions defining both the im portance of cultures to establish “Rites of Passage” membership gateways and metamorphoses from nonmember to group. Results indicated that despite often abusive hazing ceremonies in sport, marked by hierarchies, power imbalances, and, at times, criminal behaviour, there still exists a demand for an entry ritual by the rookie contingency to mark their membership and identity within the team structure. Hazing traditions continue in the belief in what Turner (1986) describes as Communitas, despite indications from participants that hazing fractured relationships on the team — a marked contradiction of Communitas.
On the ∆ f Λ 2 -Statistical Convergence on Product Time Scale

In this paper, we ﬁrst deﬁne a new density of a ∆ -measurable subset of a product time scale Λ 2 with respect to an unbounded modulus function. Then, by using this deﬁnition, we introduce the concepts of ∆ f Λ 2 -statistical convergence and ∆ f Λ 2 -statistical Cauchy for a ∆ -measurable real-valued function deﬁned on product time scale Λ 2 and also obtain some results about these new concepts. Finally, we present the deﬁnition of strong ∆ f Λ 2 -Cesaro summability on Λ 2 and investigate the connections between these new concepts.
Characterization of Pedestrian Electromagnetic Scattering at 76-77GHz

Automobile safety system has received tremendous attention in the past few years. Radar used in such system must be capable of detecting not only other vehicles but also pedestrian. Automobile radar working at 24GHz has been used in blind-spot detection (BSD) and automatic cruise control (ACC) system to track the distance and relative speed of on-road object. However, existing radars are limited to short detection range (30m) and low spatial resolution, making them less useful for pedestrian detection. A new frequency band 76-77GHz, recently designated by the Federal Communication Commission (FCC), the International Telecommunication Union (ITU) in Europe, and the Ministry of Internal Affairs and Communications (MIC) in Japan for vehicular radar. At such high frequencies, a longer detection range (100m-150m) and better resolution can be achieved. As such, it will enable more reliable detection of pedestrians in front of vehicles with lower false alarm rate. In on-road environment, multiple radar reflections may be generated from clutters like trees, trash cans, road surface, curbs and other vehicles. Therefore, it is necessary to identify unique pedestrian radar signatures in the 76-77GHz band to help discriminate them from clutters. Experimental characterization of radar response of human targets at such high frequencies is not trivial and often inaccurate due to extremely short wavelength which
Spatio-Temporal Associative Mining for Earthquake Data Distribution in Indonesia

Indonesia has the highest seismic activity in the world because it traversed by three meeting plates (Indo-Australian, Eurasian and Pacific Plate) and located in the Ring of Fire area. The shaking events of an earthquake are very strong, spread in all directions and had a seismic connection between each contiguos event based on location or time occur. The impact of an earthquake can destroy property, triggers another disaster and take so many victims. There is a seismic association between provinces in Indonesia. In this paper, we present a new earthquake Spatio-temporal mapping system based on the association confidence value from the result of associative mining process on earthquake data distribution in Indonesia. The system proposed three main functions which are (1) Data Acquisition which taken from four data provider, then preprocess and combine it become one, (2) Associative Mining process to get the rule of association earthquake between provinces in Indonesia, and (3) Earthquake Association Spatio-Temporal Model from the highest confidence value and Visualization. We use data from several earthquake data providers from 1900 until 2018. To perform our proposed Spatio-temporal earthquake association mapping system, we divided the data to become a 5-year discrete partition. After that, we mining the rule and get the highest confidence value from each period. This confidence value is used for modeling and visualization of our Spatio-temporal mapping system. As a result of this study, we manage to generate earthquake association risk mapping from 13 provinces. The low-level risk provinces are North Sumatra, Bengkulu, NTT, Gorontalo and West Papua. The moderate risk provinces are Aceh, Papua, North Sulawesi, and Maluku. The high-level risk provinces are East Java, Bali, NTB, and North Maluku.
On the Complexity of the Linkage Recon(cid:12)guration Problem (cid:3)

We consider the problem of recon(cid:12)guring a linkage of rigid straight segments from a given start to a given target position with a continuous nonin-tersecting motion. The problem is nontrivial even for trees in two dimensions since it is known that not all con(cid:12)gurations can be recon(cid:12)gured to a straight position. We show that deciding recon(cid:12)gurability for trees in two dimensions and for chains in three dimensions is PSPACE-complete.
Comparison of Polyol and Hydrothermal Methods for Synthesis of Zinc Oxide Nanoparticles

Zinc oxide (ZnO) is an inorganic semiconductor compound with a direct bandgap of 3.3 eV and is mainly used as additive in many technological applications such as cosmetic, food, and cement. The functionality of ZnO strongly depends on the particle size, crystallinity, and shape. In this work, ZnO nanoparticles (ZnONPs) were prepared using two different routes: polyol and hydrothermal processes. The products were compared using scanning tunneling microscopy, transmission electron microscopy, X-Ray diffraction, Fourier transform infrared spectroscopy, and UV-Vis. absorption spectroscopy techniques. Additionally, hydrothermal method was performed at three temperature values of 100, 120, and 150 oC and the effect of temperature on the hydrothermal synthesis of ZnONPs was also discussed in this study.
65 Collaborative work using our Virtual ~ality Network System (VLNET)

Networked Collaborative Virtual Environments (NCVE) are systems that allow several geographically distant users to collaborate within the common 3D virtual environment The users become part of the environment represented by graphical embodiments and they can interact with the environment and with each other. We analyze the importance of good graphical representation of each user for communication and collaboration. The Virtual Life Network (VLNET) system is an NCVE using sophisticated Virtual Humans as user embodiments to improve collaboration. We describe the system and some experimental applications.
Genetic changes in the transforming growth factor f8 (TGF-fi) type II receptor gene in human gastric cancer cells: Correlation with sensitivity to growth inhibition by TGF-,

We have found several genetic changes in the TGF-jl type I receptor gene In human gastric cancer cell lines resistant to the growth Inhibitor effect of TGF-fl. Southern blot analysis showed deletion of the type I receptor gene in two of eight cell lines and ation in another two lines. The single cell line we studied that is sensitive to growth inhibition by TGF-P showed no structural abnormalities of the type H receptor gene. Some of the gastric cancer cells resistant to the growth inhibitory effect of TGF-8 express either truncated or no detectable TGF-I3 type U receptor mRNAs, whereas the one that retains responsiveness to the growth inhibitory effect of TGF-13 expresses a full-size type H receptor mRNA. Immunoprecipitation followed by Western blot analysis showed parallel change in TGF-I3 type H receptor expression. Our results suggest that one of the possible mechanisms of escape from autocrine or paracrine growth control by TGF-j9 during car- cinogeness could involve genetic changes in the TGF-(3 type H receptor gene itself or altered expression of its mRNA. Members of the TGF-f3 family
F irst record of Cloeon dipterum (L.) (Ephemeroptera: Baetidae) in Buenos Aires, Argentina

Cloeon dipterum (L.) (Ephemeroptera: Baetidae) is widely distributed in temperate areas of Eurasia, whereas, in North America, it is restricted to three states of the USA and Canada, and, in South America to Chile. To confirm our hypothesis that C.dipterum has been recently introduced in Argentina, the aim of the present study was to identify the species based on molecular analyses and morphological features. To this end, nymphs were collected from three artificial habitats located in different localities of Buenos Aires province and two tributary streams of the Luján River, northeast of Buenos Aires, Argentina. Nymphs were all identified as belonging to C.dipterum thus confirming the presence of the species in Argentina. The distribution of C.dipterum in Buenos Aires, together with its absence from previously sampled sites, would indicate that the individuals recorded are introduced and already well established in the study area.
Modulation of Gene Expression by Cancer Chemopreventive Dithiolethiones through the Keap1-Nrf2 Pathway IDENTIFICATION OF NOVEL GENE CLUSTERS FOR CELL SURVIVAL*

Enzyme inducers such as 3 H -1,2-dithiole-3-thione (D3T) enhance the detoxication of environmental carcinogens and protect against neoplasia. The putative molecular sensor for inducers is Keap1, a sulfhydryl-rich protein that sequesters the transcription factor Nrf2 in the cytoplasm. Expression of these detoxication enzymes is blunted in nrf2 -deficient mice; moreover, these mice are more sensitive to carcinogenesis, and the protective actions of dithiolethiones are lost with nrf2 disruption. Hepatic gene expression profiles were examined by oligonucleotide microarray analysis in vehicle-or D3T-treated wild-type mice as well as in nrf2 single and keap1-nrf2 double knockout mice to identify those genes regulated by the Keap1-Nrf2 pathway. Transcript levels of 292 genes were elevated in wild-type mice 24 h after treatment with D3T; 79% of these genes were induced in wild-type, but not nrf2 -deficient mice. These nrf2 -dependent, D3T-inducible genes included known detoxication and antioxidative enzymes. Unexpected clusters included genes for chaperones, protein trafficking, ubiquitin/26
Reversible Comparator Circuit Design using CMOS-GDI-TG Mixed Technology

In this paper we design GDI, TG and GDI-TG Mixed based Reversible Comparator circuit (3) using 90 nm & 180nm Technology. Reversible gates using transistors has been designed using a combination of CMOS-GDI-TG circuit, which provides the optimal solution for combinational logic, saving 1/3 the power, half the area and 10% in delay relative to a CMOS implementation (7). In this paper different circuits using different technologies are implemented.