Miracle-dz/UniFAR-FTUs huggingface dataset:
Expression of MicroRNAs in Periodontal and Peri-Implant Diseases: A Systematic Review and Meta-Analysis

Aim: The purpose of this review was to evaluate the expression patterns of miRNAs in periodontal and peri-implant diseases, while identifying potential miRNAs with the greatest diagnostic ability as an oral fluid biomarker. Materials and methods: Human and animal studies were included when evaluating expression of miRNAs between health and different forms/stages of diseases, in which microarray and/or real-time polymerase chain reaction (RT-PCR) was carried out to detect fold changes in gene expression. After full-text analysis, 43 articles were considered for a qualitative assessment, and 16 miRNAs were selected to perform meta-analysis. Results: Based on human studies, results showed an overall upregulation of most of the evaluated miRNAs in periodontitis, with miRNA-142-3p and miRNA-146a being the most conclusive on both microarray and RT-PCR values and potentially serving as diagnostic biomarkers for disease activity. Conversely, miR-155 was the only miRNA revealing a statistically significant difference (SSD) (p < 0.05*) in experimental periodontitis models from RT-PCR values. Scarce scientific evidence is available from peri-implant diseases, however, most explored miRNAs in peri-implantitis were downregulated except for miR-145. Conclusions: Although our results revealed that a distinct differential expression of specific miRNAs can be noted between the state of health and disease, future research remains necessary to explore the functional role of specific miRNAs and their potential as therapeutic targets in periodontal and peri-implant diseases. MeSH Terms: periodontitis, peri-implantitis, epigenomics, microarray analysis, real-time polymerase chain reaction, microRNAs. Clinical relevance: Scientific background: Although most research identified different expression levels of miRNAs in periodontal and peri-implant diseases compared to their counterparts, their actual role in the pathogenesis of these conditions remains unclear. Therefore, we aimed to present a systematic review and meta-analysis on the expression patterns of miRNAs in periodontitis and peri-implantitis, while identifying potential miRNAs with the greatest diagnostic ability as an oral fluid biomarker. Principal findings: In periodontitis-related studies, miRNA-142-3p and miRNA-146a were the most conclusive on both microarray and RT-PCR values. Scarce scientific evidence is available from peri-implant diseases. Practical implications: Both miRNA-142-3p and miRNA-146a might serve as future diagnostic biomarkers for disease activity in periodontitis. Yet, future research remains necessary to explore the functional role of specific miRNAs and their potential as therapeutic targets in periodontal and peri-implant diseases.
Electromyographic Analysis of Shoulder Neuromuscular Activity in Women Following Breast Cancer Treatment: A Cross-Sectional Descriptive Study

Certain secondary effects derived from medical treatment in breast cancer can favor the development of alterations in shoulder biomechanics. To the best of our knowledge, persistent peripheral pain as a key factor for the development of neuromuscular activity impairments has not been analyzed. A cross-sectional descriptive study was carried out. A total of 90 women were included and allocated to three groups: (i) 30 women with persistent peripheral pain after breast cancer treatment, (ii) 30 women without pain after breast cancer treatment, and (iii) 30 healthy women. Surface electromyography was employed to measure the onset and amplitude of the muscle activity of three shoulder movements. Statistically significant differences were found in the neuromuscular activity for all the muscles and shoulder movements among women with persistent pain versus healthy women (i.e., amplitude muscle activity variable p < 0.001). Statistically significant differences were also observed in the neuromuscular activity for certain muscles in shoulder movements among women with persistent pain versus women without pain, as well as between women without pain versus healthy women. Therefore, following breast cancer treatment, women showed alterations in their shoulder neuromuscular activity, which were more significant if persistent pain existed. These findings may contribute to developing a selective therapeutic exercise program that optimizes the shoulder neuromuscular activity in women after breast cancer treatment.
Relaxation Effects of Musially Guided Resonance Breathing: A Randomized Controlled Pilot Study

Music therapy and resonance breathing (breathing at about 0.1 Hz) may be effective in treating stress-related symptoms and promoting relaxation. However, no identified study has explicitly explored the potential of integrating the working mechanisms into a combined approach using live played music to guide respiration. Therefore, the objective of the present pilot study was to evaluate the psychophysiological effects of a combined intervention. A total of 60 healthy adults were randomized to either the experimental group or the control group (where participants listened to prerecorded relaxation music). Heart rate and heart rate variability were extracted for the following 5-minute segments: Resting baseline, stress task, intervention, resting postintervention. Additionally, self-evaluation scores for relaxation and general well-being were assessed with visual analogue scales. Significant time × group interaction effects were found for general well-being (p = .028) and heart rate variability as measured by RMSSD (p < .001), indicative of increased parasympathetic outflow in the experimental group. In conclusion, the combination of music therapy and resonance breathing seems to be a well-received and effective way to induce relaxation and well-being in healthy adults.
Functional Properties of Lupin Seed (Lupinus mutabilis) Proteins and Protein Concentrates

Functional and electrophoretic properties of the seed flour and a protein concentrate prepared by alkaline extraction from lupin seeds (Lupinus mutabilis, cultivar H-6) were investigated. SDS-PAGE indicated presence of 13 and 12 subunits in the seed flour proteins and the protein concentrate, respectively. Lupin protein concentrate had good water and oil absorption and gelation properties. Solubility of lupin proteins was minimum at a pH of 4.0 but increased rapidly beyond pH 5.0. Foaming capacity of the protein concentrate could be improved by increasing concentration as well as by adding NaCl and was influenced by pH and incorporation of certain carbohydrates. Emulsion properties of lupin proteins were concentration and pH dependent. Moist heat improved the in vitro digestibility of the seed proteins. The seed flour as well as the protein concentrate did not have detectable trypsin, chymotrypsin, and α-amylase inhibitory activities.
Towards Collaboration Literacy Development through Multimodal Learning Analytics

: The last ten years has involved significant growth and development in the learning analytics community. One of the developments to recently emerge as a recognized special interest group in Learning Analytics is the sub-field of Multimodal Learning Analytics (MmLA). In this paper we consider a future trajectory for MmLA that intersects with the cross-cutting 21st century skill of collaboration. Teaching collaboration is seldom the focus of formal, or informal learning experiences, as students and teachers rarely receive feedback on their collaboration process. Instead, feedback is normally reduced to an outcome measure, or requires a level of human analysis that is intractable at scale. We see a unique opportunity for MmLA to promote collaboration literacy, and for collaboration literacy to be a common space in which to grow MmLA. Concretly, MmLA can provide the theoretical and technological innovations needed to create tools that support the evaluation, assessment and development of collaborative skills. As a first step in this direction, this paper presents a framework for collaboration literacy that consists of four levels of increasing complexity. We describe examples of current work in the first three levels of the framework, and situate the fourth level as an aspirational goal for the field of MmLA. We also discuss some of the key challenges that need to be solved to facilitate increased adoption of a collaboration literacy feedback tool, and MmLA more broadly. Ultimately, we argue that the development of such a tool could be instrumental in introducing new ways for building collaboration literacy.
Boletus rubriceps , a new species of porcini from the southwestern USA

The porcini ( Boletus s.s.) are an economically important group of ectomycorrhizal fungi whose basidiocarps have a white tube layer at first, reticulate stipe, and white flesh. The type species, B. edulis , is widespread and morphologically variable, with very little genetic variation from Eurasia to North America. Here we describe a new species of porcini, Boletus rubriceps, from the southwestern USA. Morphological characters and molecular data (ITS and LSU) distinguish this species from the Eurasian B. edulis and North American B. edulis var. grandedulis .
Automated Digital Image Clustering Algorithm Based on Colour Distance and IDBSCAN

Data clustering is inevitable for crucial data analytic based applications. Though data clustering algorithms are capacious in the literature, there is always a room for efficient data clustering algorithms. This is due to the uncontrollable growth of data and its utilization. The data clustering may consider any of the data formats such as text, images, audio, video and so on. Due to the increasing utilization trend of digital images, this work intends to present a data clustering algorithm for digital images, which is based colour distance and Improvised DBSCAN (IDBSCAN) algorithm. The proposed IDBSCAN completely weeds out the annoying process of setting the initial parameters such as 𝜺 and 𝒎𝒊𝒏𝒑𝒕𝒔 by setting them automatically. The performance of the proposed work is analysed in terms of clustering accuracy, precision, recall, Fmeasure and time consumption rates. The proposed work outperforms the existing approaches with reasonable time consumption.
Detect Frauds in Credit Card using Data Mining Techniques

In today era credit card are extensively used for day to day business as well as other transactions. Ascent within the variety of transactions through master card has junction rectifier to rise in the dishonest activities. In trendy day's fraud is one in every of the most important concern within the monetary loses not solely to the merchants however additionally to the individual purchasers. Data processing had competed a commanding role within the detection of credit card in on-line group action. Our aim is to first of all establish the categories of the fraud secondly, the techniques like K-nearest neighbor, Hidden Markov model, SVM, logistic regression, decision tree and neural network. So fraud detection systems became essential for the banks to attenuate their loses. In this paper we have research about the various detecting techniques to identify and detect the fraud through varied techniques of data mining
Morphometric, karyotypic, and molecular evidence for a new species of Peromyscus (Cricetidae: Neotominae) from Nayarit, Mexico

Abstract Historically, specimens representing the Peromyscus boylii species group (from montane regions of western and southwestern Mexico) have been referred to as P. boylii or P. levipes. However, previous studies indicated that specimens from eastern Nayarit possessed a karyotype and mitochondrial DNA haplotype distinct from other members of the P. boylii species group. Together, these data precluded an assignment of these specimens to any currently recognized taxon in the P. boylii species group. Availability of additional specimens from this region provided an opportunity to reevaluate the taxonomic status of this complex. Analyses of 18 morphological characters demonstrated that specimens from eastern Nayarit possessed a significantly longer length of the nasals relative to the other species. Further, phylogenetic analyses (parsimony and likelihood) of DNA sequences obtained from the mitochondrial cytochrome-b gene indicate these specimens form a monophyletic clade embedded within a strongly supported clade containing representatives of P. beatae, P. levipes, and P. schmidlyi. Together, these results indicated that specimens from the Sierra Madre Occidental region of Nayarit represent an undescribed species of Peromyscus. Resumen Históricamente, los especímenes que representan al grupo de especies de Peromyscus boylii (de regiones montanas del oeste y suroeste de México) han sido identificadas como P. boylii o P. levipes. Sin embargo, estudios previos han indicado que los especímenes del este de Nayarit poseen un cariotipo y un haplotipo del ADN mitocondrial distinto al de otros miembros del grupo de especies de P. boylii. Juntos, estos datos excluyen la asignación de dichos especímenes a cualquier taxón actualmente reconocido en el grupo de especies de P. boylii. La disponibilidad de muestras adicionales de esta región permitió reevaluar la taxonomía de este complejo. El análisis de 18 caracteres morfológicos demostró que los especímenes procedentes del este de Nayarit poseen una longitud significativamente mayor del hueso nasal en relación a otras especies de este complejo. Además, análisis filogenéticos (parsimonia y verosimilitud) de secuencias de ADN obtenidas del gen mitocondrial citocromo-b indican que estos especímenes forman un clado monofilético embebido dentro de otro clado que, con fuerte apoyo estadístico, contiene a representantes de P. beatae, P. levipes, y P. schmidlyi. En conjunto, todos estos resultados indican que los especímenes de la región de Sierra Madre Occidental de Nayarit representan una especie no descrita de Peromyscus.
What Drives Advocacy? An Exploration of Value, Mission, and Relationships

ABSTRACT How advocacy is interpreted and how it fits into an organization’s strategy are areas in need of additional study. Moreover, because nonprofit organizations are believed to have advocacy-based missions that drive their activities and services, the connection between an organization’s mission and its advocacy activities also needs further study. In an effort to address these issues, the purpose of this qualitative study was to explore how advocacy is interpreted in the context of an organization’s mission and how advocacy activities are viewed within human service NPOs. Five themes were identified, all providing support for findings in previous advocacy research.
Evaluation of the Insulinotrophic Activity of Malaysian Traditional Plants Extract

In this study, methanolic extracts of 14 traditional plants in Malaysia were screened for insulinotrophic properties, using rat pancreatic s-cell lines, BRIN-BD11 cells. In 30 min acute static incubation test, all 14 plants showed varying degree of responsiveness in insulin release with Labisa pumila, Morinda citrifolia, Momordica charantia and Tinospora crispa having high insulinotrophic activities. These plants also displayed appreciably low cytotoxic activities. These results show a promising avenue for development of novel insulin secretagogues.
A Cross-sectional Growth Study of Forearm Length and Tibial Length in an Indigenous Andean Population of 6 to 19 Years of Age

Patterns of growth in forearm length and tibial length were studied in 149 school-children of Aymara ancestry (73 boys and 76 girls), aged 6 to 19 years. The investigation was based on a cross-sectional survey performed in 1987 in the rural community of Putre (3, 530 m), northern Chile. The results show that there is little sexual dimorphism over the age period of 6 to 13 years, while sex differences are more pronounced between the ages of 14 and 17 years, both for forearm length and tibial length, with boys having higher means. Correspondingly, the maximum values achieved for both measurements are greater in boys than in girls. The growth spurt begins about two years earlier in girls than in boys. In both sexes, tibial growth precedes forearm growth. The analysis of growth relationships between forearm length and tibial length in relation to other measurements shows higher positive correlations to stature than to sitting height. Inter-populational comparisons between the extremity growth pattern of the Aymara children and that of children of different ethnic ancestry reveal that at all ages, the Aymara have longer forearms in propor-tion to their tibiae than is the case with children of Asiatic, European and African ancestry. It is suggested that the relatively longer forearms in the Aymara might be related to their larger thoracic dimensions.
Groundwater Vulnerability Assessment of Plant Protection Products: A Review

ABSTRACT Plant protection products (PPPs) pose a serious dilemma; although their application contributes to the fight against poverty and diseases, at the same time these agrochemicals represent a significant public health threat. As part of Ireland's commitment to the Water Framework Directive (WFD), the country's groundwater sources and resources have to be properly monitored and specific standards in groundwater quality need to be met. Vulnerability assessment is a methodology that evaluates the likelihood of an adverse event occurring and this information can be useful for pollution prevention and decision-making purposes. The objective of this article is to review and compare the most important vulnerability assessment methods and tools that have been used in catchment/regional scale studies. While the approach used is largely dependent on available data, user requirements, and local conditions, the evaluation showed that the COP and PI index-based methods and the MACRO and PRZM process-based methods represent the most advanced tools currently available for large-scale applications. Also discussed is the importance of statistical methods for uncertainty analysis and their usefulness in reducing the data requirements of the index and process-based methods.
Are land bird assemblages functionally saturated? An empirical test in Mexico

According to the model of ideal free distribution, few or no assemblages will contain unused resources as long as species are free to colonize areas where resources are available. Consequently, because several food resources for birds are available throughout Mexico (nectar, seeds and fruits, vertebrates, carrion and different types of invertebrates), we predicted that all assemblages from Mexico contain birds from the corresponding foraging guilds. However, severe climates may prevent colonization by certain birds. Thus, a second prediction was that, if assemblages with unused resources were found, these would be from localities with climates that pose extreme stress (either extremely high temperature and low rainfall, or extremely low temperature). We tested these predictions on bird assemblages from 77 localities that represent the entire range of climatic conditions found in Mexico. Only two assemblages containing unused resources were found. These were from the localities with lowest temperature and lowest rainfall, respectively. We observed that land bird assemblages in Mexico do not contain unused resources, except when climate selectively restricts colonization by species from certain foraging guilds. Therefore, we conclude that even assemblages with almost no species in common have a common guild structure based on food resources. Null models of competition would be more realistic if they were to incorporate such patterns in their regional species pools.
Predicting spring oviposition by raspberry cane midge from accumulated derived soil temperatures

Summary An accumulated soil temperature model is described which calculates the first oviposition date for overwintered populations of the raspberry cane midge (Resseliella theobaldi). The model uses values for mean 10 cm soil temperature, derived from daily maximum and minimum air temperatures and 10 cm soil temperature at 0900 GMT. It was developed by minimising the variation between observed dates for the start of oviposition over an 8-yr period and accumulated air or soil temperature, using a series of base temperatures. The best fit was obtained with soil temperatures accumulated above a base temperature of 4°C. Oviposition was predicted to start when the daily accumulated soil temperature reached 339°C days above a base temperature of 4°C. Field observations and model predictions suggested that emergence and oviposition dates were influenced by the direction of the slope of raspberry plantations. To compensate for this, an empirical correction has been incorporated into the model to advance or retard the predicted oviposition date by adjusting the estimated maximum soil temperature to allow for aspect. The geographical variation between dates for first oviposition was simulated by running the model for nine meteorological sites in the UK in 1985 and 1986.
Trade, Patents and International Technology Diffusion

This paper investigates international technology diffusion through trade and patenting in a sample of 48 countries for the period 1980 – 2000. We divide the sample in three income groups to detect different patterns of technology absorption. Our results show that rich countries benefit from domestic technology and foreign technology embodied in imported capital goods, middle-income countries enjoy technology spillovers from foreign patents and imported capital goods, and poor countries benefit mainly from foreign patents. We find that government policies on intellectual property rights protection and trade openness have large effects on foreign technology spillovers in middle- and low-income countries.
Changes in polyamine synthesis during anther development and pollen germination in tobacco (Nicotiana tabacum)

Changes in polyamine levels and in the activities of arginine decarboxylase (ADC, EC 4.1.1.19) and omithine decarboxylase (ODC. EC 4.1.1.17) were studied during anther development in Nicotiana tabacum as well as during the first 120 min of dry pollen germination in vitro. Arginine decarboxylase activity was more abundant than that of ODC in the whole anther and isolated pollen: activities of both enzymes reached a maximum at the binucleate stage of pollen development and increased with elongation of the pollen tube. During anther development, no alteration in free putrescine (Put) or in free spermidine (Spd) was found from the microspore to the binucleate stage. However, during maturation, free Put decreased, probably because of its transformation into Spd. Bound polyammes were more abundant than the free polyamines during anther development. The presence of a-amanitin. on inhibitor of transcription, did not affect ADC activity during the germination process, whereas cycloheximide. on inhibitor of protein synthesis, had a strong inhibitory effect. Compared to their levels in dry pollen, free Put. Spd and spermine (Spm), and bound Put were present at increased levels during pollen tube elongation. However, in the presence of cycloheximide. which had little effect on elongation of the pollen tube, free polyamine synthesis was inhibited. In light of the results obtained with cycloheximide and difluoromethvlargi-nine. An inhibitor of arginine decarboxylase. which inhibited elongation but not emergence of the pollen tube, we propose that the endogenous polyamine liter in dry pollen was sufficient to contribute to the emergence of the pollen tube and. once emergence was established, that pre-existent ADC and ODC were responsible for the synthesis of those polyaraines related to tube elongation, since the polyamine levels of the dry pollen appeared to be insufficient.