Miracle-dz/UniFAR-FTUs huggingface dataset:
An Inventory of Problems–29 Sensitivity Study Investigating Feigning of Four Different Symptom Presentations Via Malingering Experimental Paradigm

Abstract The Inventory of Problems–29 (IOP–29) is a newly developed, self-administered test designed to assist practitioners evaluating the credibility of various symptom presentations. In a recent simulation study comparing real patients against experimental feigners, its classification accuracy compared favorably with that of the Structured Inventory of Malingered Symptomatology and generalized better to different types of symptom reports (i.e., mood- or trauma-related vs. psychosis-related). Extending on these findings, this sensitivity study tested whether the IOP–29 would be similarly accurate in detecting feigning of conditions related to depression, mild traumatic brain injury, posttraumatic stress disorder (PTSD), and schizophrenia. Additionally, it also evaluated the susceptibility of the IOP–29 to uncooperative or random-like responding. Examination of 1,200 IOP–29 records from 400 nonclinical Italian volunteers who took the Italian version of the IOP–29 3 times, in 3 different conditions (i.e., standard instructions, feigned disorder, and random-like responding), confirmed that the IOP–29 might be similarly valid across a wide variety of mental health and cognitive complaints. Indeed, using the standard a priori cutoff of the IOP–29 (i.e., ≥ .50), sensitivity estimates ranged from . 86 (for feigned PTSD) to . 95 (for feigned depression) and did not significantly differ from one symptom presentation to another. These findings were obtained despite the fact that participants were coached to respond in a believable manner. Interestingly, the random-like responding generated extremely variable IOP–29 scores.
Systemic oscillator-driven and nutrient-responsive hormonal regulation of daily expression rhythms for gluconeogenic enzyme genes in the mouse liver

ABSTRACT Gluconeogenesis is de novo glucose synthesis from substrates such as amino acids and is vital when glucose is lacking in the diurnal nutritional fluctuation. Accordingly, genes for hepatic gluconeogenic enzymes exhibit daily expression rhythms, whose detailed regulations under nutritional variations remain elusive. As a first step, we performed general systematic characterization of daily expression profiles of gluconeogenic enzyme genes for phosphoenolpyruvate carboxykinase (PEPCK), cytosolic form (Pck1), glucose-6-phosphatase (G6Pase), catalytic subunit (G6pc), and tyrosine aminotransferase (TAT) (Tat) in the mouse liver. On a standard diet fed ad libitum, mRNA levels of these genes showed robust daily rhythms with a peak or an elevation phase during the late sleep-fasting period in the diurnal feeding/fasting (wake/sleep) cycle. The rhythmicity was preserved in constant darkness, modulated with prolonged fasting, attenuated by Clock mutation, and entrained to varied photoperiods and time-restricted feedings. These results are concordant with the notion that gluconeogenic enzyme genes are under the control of the intrinsic circadian oscillator, which is entrained by the light/dark cycle, and which in turn entrains the feeding/fasting cycle and also drives systemic signaling pathways such as the hypothalamic-pituitary-adrenal axis. On the other hand, time-restricted feedings also showed that the ingestion schedule, when separated from the light/dark cycle, can serve as an independent entrainer to daily expression rhythms of gluconeogenic enzyme genes. Moreover, nutritional changes dramatically modified expression profiles of the genes. In addition to prolonged fasting, a high-fat diet and a high-carbohydrate (no-protein) diet caused modification of daily expression rhythms of the genes, with characteristic changes in profiles of glucoregulatory hormones such as corticosterone, glucagon, and insulin, as well as their modulators including ghrelin, leptin, resistin, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1). Remarkably, high-protein (60% casein or soy-protein) diets activated the gluconeogenic enzyme genes atypically during the wake-feeding period, with paradoxical up-regulation of glucagon, which frequently formed correlation networks with other humoral factors. Based on these results, we propose that daily expression rhythms of gluconeogenic enzyme genes are under the control of systemic oscillator-driven and nutrient-responsive hormones.
Plant seed-inspired cell protection, dormancy, and growth for large-scale biofabrication

Biofabrication technologies have endowed us with the capability to fabricate complex biological constructs. However, cytotoxic biofabrication conditions have been a major challenge for their clinical application, leading to a trade-off between cell viability and scalability of biofabricated constructs. Taking inspiration from nature, we proposed a cell protection strategy which mimicks the protected and dormant state of plant seeds in adverse external conditions and their germination in response to appropriate environmental cues. Applying this bioinspired strategy to biofabrication, we successfully preserved cell viability and enhanced the seeding of cell-laden biofabricated constructs via a cytoprotective pyrogallol (PG)-alginate encapsulation system. Our cytoprotective encapsulation technology utilizes PG-triggered sporulation and germination processes to preserve cells, is mechanically robust, chemically resistant, and highly customizable to adequately match cell protectability with cytotoxicity of biofabrication conditions. More importantly, the facile and tunable decapsulation of our PG-alginate system allows for effective germination of dormant cells, under typical culture conditions. With this approach, we have successfully achieved a biofabrication process which is reproducible, scalable, and provided a practical solution for off-the-shelf availability, shipping and temporary storage of fabricated bio-constructs.
Passive Commuting and Higher Sedentary Time Is Associated with Vitamin D Deficiency in Adult and Older Women: Results from Chilean National Health Survey 2016–2017

The aim was to investigate the associations between different physical activity (PA) patterns and sedentary time (ST) with vitamin D deficiency (<12 ng/mL) in a large sample of Chilean women. In this cross-sectional study, the final sample included 1245 adult and 686 older women. The PA levels, mode of commuting, ST, and leisure-time PA were self-reported. Vitamin D deficiency was defined as <12 ng/mL and insufficiency as <20 ng/mL. A higher ST was associated with vitamin D deficiency (odds ratio (OR): 2.4, 95%: 1.6–4.3) in adults, and passive commuting was associated with vitamin D deficiency in older (OR: 1.7, 95%: 1.1–2.7). Additionally, we found a joint association in the high ST/passive commuting group in adults (OR: 2.8, 95%: 1.6–4.9) and older (OR: 2.8, 95%: 1.5–5.2) with vitamin D deficiency, in respect to low ST/active commuting. The PA levels and leisure-time PA were not associated with vitamin D deficiency. In conclusion, mode of commuting and ST seems important variables related to vitamin D deficiency. Promoting a healthy lifestyle appears important also for vitamin D levels in adult and older women. Further studies are needed to establish causality of this association and the effect of vitamin D deficiency in different diseases in this population.
Maternal neglect and the serotonin system are associated with daytime sleep in infant rhesus monkeys

Abstract Environmental and biological factors contribute to sleep development during infancy. Parenting plays a particularly important role in modulating infant sleep, potentially via the serotonin system, which is itself involved in regulating infant sleep. We hypothesized that maternal neglect and serotonin system dysregulation would be associated with daytime sleep in infant rhesus monkeys. Subjects were nursery-reared infant rhesus macaques (n = 287). During the first month of life, daytime sleep-wake states were rated bihourly (0800–2100). Infants were considered neglected (n = 16) if before nursery-rearing, their mother repeatedly failed to retrieve them. Serotonin transporter genotype and concentrations of cerebrospinal fluid 5-hydroxyindoleacetic acid (5-HIAA) were used as markers of central serotonin system functioning. t tests showed that neglected infants were observed sleeping less frequently, weighed less, and had higher 5-HIAA than non-neglected nursery-reared infants. Regression revealed that serotonin transporter genotype moderated the relationship between 5-HIAA and daytime sleep: in subjects possessing the Ls genotype, there was a positive correlation between 5-HIAA and daytime sleep, whereas in subjects possessing the LL genotype there was no association. These results highlight the pivotal roles that parents and the serotonin system play in sleep development. Daytime sleep alterations observed in neglected infants may partially derive from serotonin system dysregulation.
Volume visualization of 3D finite element method results

This paper describes a method for visualizing the output data set of a 3D finite element method result. A linear tetrahedral element is used as a primitive for the visualization processing, and a 3D finite element model is subdivided into a set of these primitives, which are generated at every s< îd element. With these primitives, isosurfaces are visualized semltransparentiy from scalar data at each node point. Two methods are developed for the visualization of isosurfaces with and without inteimediate geometries. The methods are applied to output data sets from some simulation results of a semiconductor chip. These are visualized, and the effectiveness of the method is discussed.
Fenfluramine, a serotonin‐releasing drug, prevents seizure‐induced respiratory arrest and is anticonvulsant in the DBA/1 mouse model of SUDEP

Prevention of sudden unexpected death in epilepsy (SUDEP) is a critical goal for epilepsy therapy. The DBA/1 mouse model of SUDEP exhibits an elevated susceptibility to seizure‐induced death in response to electroconvulsive shock, hyperthermia, convulsant drug, and acoustic stimulation. The serotonin hypothesis of SUDEP is based on findings that treatments which modify serotonergic function significantly alter susceptibility to seizure‐induced sudden death in several epilepsy models, including DBA/1 mice. Serotonergic abnormalities have also recently been observed in human SUDEP. Fenfluramine is a drug that enhances serotonin release in the brain. Recent studies have found that the addition of fenfluramine improved seizure control in patients with Dravet syndrome, which has a high incidence of SUDEP. Therefore, we investigated the effects of fenfluramine on seizures and seizure‐induced respiratory arrest (S‐IRA) in DBA/1 mice.
Impact of abrupt sea ice loss on Greenland water isotopes during the last glacial period

Significance The Dansgaard–Oeschger events contained in Greenland ice cores constitute the archetypal record of abrupt climate change. An accurate understanding of these events hinges on interpretation of Greenland records of oxygen and nitrogen isotopes. We present here the important results from a suite of modeled Dansgaard–Oeschger events. These simulations show that the change in oxygen isotope per degree of warming becomes smaller during larger events. Abrupt reductions in sea ice also emerge as a strong control on ice core oxygen isotopes because of the influence on both the moisture source and the regional temperature increase. This work confirms the significance of sea ice for past abrupt warming events. Greenland ice cores provide excellent evidence of past abrupt climate changes. However, there is no universally accepted theory of how and why these Dansgaard–Oeschger (DO) events occur. Several mechanisms have been proposed to explain DO events, including sea ice, ice shelf buildup, ice sheets, atmospheric circulation, and meltwater changes. DO event temperature reconstructions depend on the stable water isotope (δ18O) and nitrogen isotope measurements from Greenland ice cores: interpretation of these measurements holds the key to understanding the nature of DO events. Here, we demonstrate the primary importance of sea ice as a control on Greenland ice core δ18O: 95% of the variability in δ18O in southern Greenland is explained by DO event sea ice changes. Our suite of DO events, simulated using a general circulation model, accurately captures the amplitude of δ18O enrichment during the abrupt DO event onsets. Simulated geographical variability is broadly consistent with available ice core evidence. We find an hitherto unknown sensitivity of the δ18O paleothermometer to the magnitude of DO event temperature increase: the change in δ18O per Kelvin temperature increase reduces with DO event amplitude. We show that this effect is controlled by precipitation seasonality.
Perinatal Navigator Approach to Smoking Cessation for Women With Prevalent Opioid Dependence

Women who smoke during pregnancy face psychosocial barriers to cessation, and women with opioid use disorder (OUD) face amplified barriers. We pilot tested a Perinatal Wellness Navigator (PWN) program for a group of high-risk perinatal women (N = 50; n = 42 with OUD) that consisted of (a) one-on-one tobacco treatment, (b) comprehensive assessment of cessation barriers, and (c) linkage to clinical/social services. Outcome measures were assessed at baseline and postintervention. Participants smoked 10 fewer cigarettes per day (p = .05) at postintervention and were less dependent on nicotine (p < .01). Mean postnatal depression scores (p = .03) and perceived stress (p = .03) decreased postintervention. Participants received at least one referral at baseline (n = 106 total), and 10 participants received an additional 18 referrals at postintervention to address cessation barriers. The PWN program was minimally effective in promoting total tobacco abstinence in a high-risk group of perinatal women, but participants experienced reductions in cigarettes smoked per day, nicotine dependence, stress, and depression.
Cerebrospinal fluid biogenic amines depletion and brain atrophy in adult patients with phenylketonuria

Biogenic amines synthesis in phenylketonuria (PKU) patients with high phenylalanine (Phe) concentration is thought to be impaired due to inhibition of tyrosine and tryptophan hydroxylases and competition with amino acids at the blood‐brain barrier. Dopamine and serotonin deficits might explain brain damage and progressive neuropsychiatric impairment in adult PKU patients. Ten early treated adult PKU patients (mean age 38.2 years) and 15 age‐matched controls entered the study. Plasma and cerebrospinal fluid (CSF) Phe, 5‐hydroxyindoleacetic acid (5‐HIAA), 5‐hydroxytryptophan (5‐HTP), 3,4‐dihydroxy‐l‐phenylalanine (l‐DOPA) and homovanillic acid (HVA) were analyzed. Voxel‐based morphometry statistical nonparametric mapping was used to test the age‐corrected correlation between gray matter atrophy and CSF biogenic amines levels. 5‐HIAA and 5‐HTP were significantly reduced in PKU patients compared to controls. Significant negative correlations were found between CSF 5‐HIAA, HVA, and 5‐HTP and Phe levels. A decrease in 5‐HIAA and 5‐HTP concentrations correlated with precuneus and frontal atrophy, respectively. Lower HVA levels correlated with occipital atrophy. Biogenic amines deficits correlate with specific brain atrophy patterns in adult PKU patients, in line with serotonin and dopamine projections. These findings may support a more rigorous Phe control in adult PKU to prevent neurotransmitter depletion and accelerated brain damage due to aging.
Decoding competing endogenous RNA networks for cancer biomarker discovery

Crosstalk between competing endogenous RNAs (ceRNAs) is mediated by shared microRNAs (miRNAs) and plays important roles both in normal physiology and tumorigenesis; thus, it is attractive for systems-level decoding of gene regulation. As ceRNA networks link the function of miRNAs with that of transcripts sharing the same miRNA response elements (MREs), e.g. pseudogenes, competing mRNAs, long non-coding RNAs, and circular RNAs, the perturbation of crucial interactions in ceRNA networks may contribute to carcinogenesis by affecting the balance of cellular regulatory system. Therefore, discovering biomarkers that indicate cancer initiation, development, and/or therapeutic responses via reconstructing and analyzing ceRNA networks is of clinical significance. In this review, the regulatory function of ceRNAs in cancer and crucial determinants of ceRNA crosstalk are firstly discussed to gain a global understanding of ceRNA-mediated carcinogenesis. Then, computational and experimental approaches for ceRNA network reconstruction and ceRNA validation, respectively, are described from a systems biology perspective. We focus on strategies for biomarker identification based on analyzing ceRNA networks and highlight the translational applications of ceRNA biomarkers for cancer management. This article will shed light on the significance of miRNA-mediated ceRNA interactions and provide important clues for discovering ceRNA network-based biomarker in cancer biology, thereby accelerating the pace of precision medicine and healthcare for cancer patients.
Utility of Magnetic Resonance Imaging in Diagnosis and Monitoring Enthesitis in Patients with Spondyloarthritis: An OMERACT Systematic Literature Review

Objective. A systematic literature review was performed to document published magnetic resonance imaging (MRI) lesion definitions and scoring systems for enthesitis in spondyloarthritis (SpA). Methods. PubMed, Embase, and Cochrane Library databases were searched for original publications involving adult patients with SpA undergoing MRI of axial/peripheral joints. Selected articles were assessed for quality using a standardized assessment tool and metric indices. Results. Considering the heterogeneous design, quality, and outcome measures of studies, statistical data pooling was considered inappropriate. A qualitative narrative of results was undertaken based on study designs. Conclusion. Lack of a comprehensive, validated score warrants additional research to develop an MRI enthesitis scoring system. PROSPERO registration number: CRD42018090537.
F‐box protein FBXO16 functions as a tumor suppressor by attenuating nuclear β‐catenin function

Aberrant activation of β‐catenin has been implicated in a variety of human diseases, including cancer. In spite of significant progress, the regulation of active Wnt/β‐catenin‐signaling pathways is still poorly understood. In this study, we show that F‐box protein 16 (FBXO16) is a putative tumor suppressor. It is a component of the SCF (SKP1‐Cullin1‐F‐box protein) complex, which targets the nuclear β‐catenin protein to facilitate proteasomal degradation through the 26S proteasome. FBXO16 interacts physically with the C‐terminal domain of β‐catenin and promotes its lysine 48‐linked polyubiquitination. In addition, it inhibits epithelial‐to‐mesenchymal transition (EMT) by attenuating the level of β‐catenin. Therefore, depletion of FBXO16 leads to increased levels of β‐catenin, which then promotes cell invasion, tumor growth, and EMT of cancer cells. Furthermore, FBXO16 and β‐catenin share an inverse correlation of cellular expression in clinical breast cancer patient samples. In summary, we propose that FBXO16 functions as a putative tumor suppressor by forming an SCFFBXO16 complex that targets nuclear β‐catenin in a unique manner for ubiquitination and subsequent proteasomal degradation to prevent malignancy. This work suggests a novel therapeutic strategy against human cancers related to aberrant β‐catenin activation. © 2019 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
Patterns of rangeland productivity and land ownership: Implications for conservation and management

Abstract Rangelands cover 40–50% of the Earth's terrestrial surface. While often characterized by limited, yet variable resource availability, rangelands are vital for humans, providing numerous ecosystem goods and services. In the conterminous United States (CONUS), the dominant component of rangeland conservation is a network of public rangelands, concentrated in the west. Public rangelands are interspersed with private and tribal rangelands resulting in a complex mosaic of land tenure and management priorities. We quantify ownership patterns of rangeland production at multiple scales across CONUS and find that both total production and average productivity of private rangelands is more than twice that of public and tribal rangelands. At finer scales, private rangelands are consistently more productive than their public counterparts. We also demonstrate an inverse relationship between public rangeland acreage and productivity. While conserving acreage is crucial to rangeland conservation, just as critical are broad‐scale ecological patterns and processes that sustain ecosystem services. Across CONUS, ownership regimes capture distinct elements of these patterns and services, demonstrated through disparate production dynamics. As ownership determines the range of feasible conservation actions, and the technical and financial resources available to implement them, understanding ownership‐production dynamics is critical for effective and sustained conservation of rangeland ecosystem services.
Avoiding topsy-turvy: how Anna's hummingbirds (Calypte anna) fly through upward gusts

ABSTRACT Flying organisms frequently confront the challenge of maintaining stability when moving within highly dynamic airflows near the Earth's surface. Either aerodynamic or inertial forces generated by appendages and other structures, such as the tail, may be used to offset aerial perturbations, but these responses have not been well characterized. To better understand how hummingbirds modify wing and tail motions in response to individual gusts, we filmed Anna's hummingbirds as they negotiated an upward jet of fast-moving air. Birds exhibited large variation in wing elevation, tail pitch and tail fan angles among transits as they repeatedly negotiated the same gust, and often exhibited a dramatic decrease in body angle (29±6 deg) post-transit. After extracting three-dimensional kinematic features, we identified a spectrum of control strategies for gust transit, with one extreme involving continuous flapping, no tail fanning and little disruption to body posture (23±3 deg downward pitch), and the other extreme characterized by dorsal wing pausing, tail fanning and greater downward body pitch (38±4 deg). The use of a deflectable tail on a glider model transiting the same gust resulted in enhanced stability and can easily be implemented in the design of aerial robots. Summary: Hummingbirds flying through intense upward gusts experience pronounced downward pitching motions (i.e. nose dives). In response, they interrupt flapping, hold the wings dorsally, and angle and fan the tail.