Miracle-dz/UniFAR-FTUs huggingface dataset:
Wafer-scale microdevice transfer/interconnect: its application in an AFM-based data-storage system

We have developed a robust, CMOS back end of the line (BEOL) compatible, wafer-scale device transfer, and interconnect method for batch fabricating systems on chip that are especially suitable for MEMS or VLSI-MEMS applications. We have applied this method to transfer arrays of 4096 free-standing cantilevers with good cantilever flatness control and high-density vertical electrical interconnects to the receiver wafer (typically CMOS). Such an array is used in a highly parallel, scanning-probe-based data-storage system, which we internally call "millipede. " A very high-integration density has been achieved, even for wafer-scale transfer, thanks to the interlocking nature of the interconnect structure, which provides easy alignment with an accuracy of 2 /spl mu/m. The typical integration density is 100 cantilevers/mm/sup 2/ and 300 electrical interconnects/mm/sup 2/. Note that only the cantilevers, not a chip with cantilevers, are transferred and, unlike flip-chip technology, our method preserves the device orientation, which is crucial for MEMS applications, where often the MEMS device should have access to its environment (in our case, the cantilever tips are in contact with the storage medium). After device transfer, the system is mechanically and electrically stable up to at least 500/spl deg/C, allowing post-transfer wafer processing.
Comparison of the histology and immunohistochemistry of vaccination-site and non-vaccination-site sarcomas from cats in New Zealand

Abstract AIMS: To compare the histology and immunohistochemistry of vaccination-site sarcomas (VSSs) with non-vaccination-site sarcomas (NVSSs) in cats in New Zealand. To determine whether VSSs in cats in New Zealand have similar histological and immunohistochemical features to those previously described in feline vaccine-associated sarcomas (VASs) in North American studies. METHODS: A retrospective survey of skin biopsies submitted between 2004 and 2006 was performed to identify cutaneous sarcomas from both vaccination and non-vaccination sites in cats. Vaccination sites included the interscapular, shoulder, or dorsal or lateral cervical and thoracic regions. All sarcomas were examined histologically, and smooth muscle actin and desmin were assessed immunohistochemically. Features previously described in VASs were assessed and compared. RESULTS: Sarcomas from 34 cats were identified, 10 of which occurred at vaccination sites. Compared with NVSSs, VSSs were more likely to be located in the hypodermis and have greater cellular pleomorphism, higher mitotic rates, more frequent peripheral lymphocytic aggregates and multinucleated giant cells. VSSs were also more likely than NVSSs to show partial myofibroblastic differentiation, demonstrable using immunohistochemistry. The histological and immunohistochemical features of VSSs in cats in New Zealand are consistent with those previously described in VASs in cats in North America. CONCLUSIONS: The results of this study suggest that VASs occur in cats in New Zealand. CLINICAL RELEVANCE: The occurrence of VASs in cats in New Zealand would provide further support for restriction of the vaccination of cats to the minimum necessary to protect health, and adoption of the New Zealand Veterinary Association guidelines on vaccination.
Proof mass effects on spiral electrode d33 mode piezoelectric diaphragm-based energy harvester

This paper presents the characterization of an energy harvester using a piezoelectric diaphragm as the vibration energy conversion microstructure. The diaphragm containing the spiral electrode operates in the d33 mode. The energy harvesting performance of the diaphragm was characterized. The optimal resistance load and the working frequency were characterized. The resonance tuning and the energy harvesting enhancement due to a proof mass were verified.
Position estimation with voltage pulse test signals for Permanent Magnet Synchronous Machines using Matrix Converters

This paper deals with the rotor angle estimation of permanent magnet AC machines using test voltage vectors. In concrete, due to the machine saliency (difference between Ld and Lq) and the application of pulse voltage test vectors is possible to estimate the permanent magnet position for further low and zero speed sensorless control. The novelty of this paper is the fact that a matrix converter is used instead of the conventional voltage source inverter. The direct AC/AC or matrix converter is a novel topology of great interest in specific wind energy applications since it avoids the use of electrolytic DC coupling capacitors, which is a potential source of failures. The paper presents the position signals for matrix converters and shows all the control algorithm. Finally, some simulation results with proper angle estimation, when speed reversal, corroborates the proper functionality of the control scheme.
Screening of Insect Cell Lines for the Production of Recombinant Proteins and Infectious Virus in the Baculovirus Expression System

Eight cell lines derived from the insects Spodoptera frugiperda, Trichoplusia ni, Mamestra brassicae, and Estigmene acrea were evaluated for recombinant β‐galac‐tosidase and infectious virus production following infection with the baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV). Production was assessed on a specific (per cell and per microgram of uninfected cellular protein) and on a volumetric (per milliliter) basis. Cell density was found to be an important factor in comparing the cell lines due to a density‐dependent inhibition of specific protein and virus production that appeared to result from cell‐cell contact. After infection of cells at low‐density specific β‐galactosidase production per cell would drop between β‐ and 6‐fold in five of the eight cell lines when plated on tissue culture plates at near‐confluent and confluent cell densities. The cell lines Sf 21 and Sf 9 were least sensitive to cell density. After accounting for cell density effects and differences in cell size, two cell lines, BTI Tn 5B1‐4 and BTI TnM, were identified that were superior to the other cell lines, including Sf 21 and Sf 9, in β‐galactosidase production. Optimal volumetric and specific β‐galactosidase production from Tn 5B1‐4 and TnM cells was 2‐fold and 5‐fold higher, respectively, in both cell lines than the optimal production from Sf 9 or Sf 21 cells. The Tn 5B1‐4 cell line also had the highest viability of all the cell lines at 3 days postinfection and could be adapted to serum‐free media. Specific (per microgram of cellular protein) infectious virus production between cell lines varied by less than 2‐fold between cell lines after cell size differences were taken into account. No correlation was found between recombinant protein and NOV production although both were found to decrease similarly with increasing cell density.
New briarane-type diterpenoids from gorgonian Ellisella dollfusi from the South China Sea

Two new briarane-type diterpenoids, dollfusilin A (1) and dollfusilin B (2), along with five known briarane-type diterpenoids (3–7), were isolated from the gorgonian Ellisella dollfusi collected from the South China Sea. The structures of the two new compounds (1 and 2) were elucidated through a comprehensive analysis of spectroscopic data, especially 2D NMR. The bioactivities of the isolated compounds were evaluated using the zebrafish toxicity model.
Dynamic time-frequency waveforms for VSA characterization of PA long-term memory effects

This paper presents a new two-tone measurement signal with dynamic frequency characteristics for PA memory evaluation using a Vector Signal Analyser, VSA, as the instrumentation measurement tool. This new dynamic frequency waveform enables nonlinear PA characterization over frequency with a single measurement similar to what is done for sequential two-tone measurements when the tone spacing is varied over multiple different frequencies. Measurements are conducted in order to characterize a PA with memory effects manifestation. Moreover all the previous measurements capabilities that were made with a Transition Analyser are expanded here with use of a VSA. This will impose synchronization problems that will also be described on the paper.
Anomalous average distance and retrievals of terrain surface moisture by using the SSM/I and AMSR-E data in operational mode

Denoting the polarization difference, a polarization index (PI) of microwave radiance from the terrain surface (half-space of canopy-soil land) is derived from the radiative transfer model. This PI separates the radiance effects of the canopy-soil moisture and interference from surface roughness and atmosphere, and are suitable to detect change of terrain surface moisture, especially for extreme drought or floods conditions. As example, the statistics of the monthly average > < PI from 6 years data of the DMSP SSM/I observations at lowest 19.35 GHz channel as available are applied to demonstration of the terrain surface status over large and heterogeneous territory such as China. The deviation of the PI data at the same month from the > < PI , i.e. PI n ∆ ) / ) ( ( > < > < − ≡ PI PI PI , gives prominence to focusing moisture variation of terrain surface and its anomaly shows possible drought or floods occurrence in extreme conditions. The PI n ∆ mapping is validated by the examples of the drought in China’s Shanxi area in May 2001 and the flood around China’s Yangtze River in August 1998, respectively. Our approach is recommended to lower frequency channels to minimize the influence from vegetation canopy for future application (such as the channels of the AMSR-E launched in May 2002 and microwave imaging radiometer of China’s Fengyun satellite series). When the monthly > < PI and the ground truth of average volumetric moisture > < v m of the region are correctly evaluated, it is tractable to retrieve the soil land surface moisture by using the PI data at the same month and the same region without much knowledge of surface roughness, vegetation canopy and others. As an example, the retrieval of v m is favorably tested by using the TRMM TMI data.
Generating multiple summaries based on computational model of perspective

Every story about an event offers a unique perspective about the event. A popular sporting event, such as a Major League Baseball game, is followed by several summary articles that show different points of view. The goal of this research is to build a computational model of perspective and build a system for automatically generating multiple summary articles showing different perspectives. My approach is to take a neutral summary article, reorder the content of that summary based on event features extracted from the description of the game, and produce two new summaries showing the local team perspectives. I will present an initial user survey that validated the hypothesis that content ordering has a significant effect on the users' perception of perspective. I will also discuss collecting and analyzing a parallel corpus of baseball game data and summary articles showing local team perspectives. I will then describe the reordering algorithm, the implementation of the system, and a user study to evaluate the output of the system. Thesis Supervisor: Howard Shrobe Title: Principal Research Scientist
Circulating Levels and Bone Contents of Bone γ-Carboxyglutamic Acid-Containing Protein Are Decreased in Streptozocin-Induced Diabetes: Possible Marker for Diabetic Osteopenia

To investigate the pathophysiology of diabetic osteopenia, circulating levels and bone contents of bone γ-carboxyglutamic acid-containing protein (BGP) were measured in streptozocin-induced diabetic rats . Plasma calcium and total protein were significantly decreased (P < .01) in the diabetic group, and the plasma level of BGP in diabetic rats was 19.6 ± 2.8 (mean ± SE) ng/ml, which is significantly lower than the value of 89.2 ± 14.0 ng/ml in control rats (P < .01). Bone contents of calcium and hydroxyproline per femur were significantly decreased in the diabetic group (P < .01), and the ratios of bone calcium to hydroxyproline were not different. Bone BGP content per femur in the diabetic group was 669 ± 58 μg, which was also significantly lower compared with 1241 ± 126 μg in control rats (P < .01). The decreased bone content of BGP is consistent with the hypothesis that BGP synthesis is impaired in insulin-deficient diabetes. Because a relationship between plasma levels of BGP and bone turnover has been established, the low plasma BGP value suggests there is a decrease in bone turnover in diabetic rats. Therefore, we postulate that the low bone turnover is one of the pathological features of diabetic osteopenia and is at least partly responsible for the occurrence of this complication in diabetes mellitus.
Neural dynamics and sliding mode integration for the guidance of unmanned surface vehicles

The purpose of this work is the development of a hybrid guidance and control system for the trajectory tracking task of an underactuated Unmanned Surface Vehicle (USV). The novelty of the guidance system is based on neural dynamics and sliding mode integration. The biological neural dynamics model is designed to smooth the outputs of the sliding mode control, avoid sharp speed jumps and satisfy the thruster control constraint. The outputs of the sliding mode controller are used such as the reference inputs of an internal backstepping control loop for low level dynamics regulation. The hybrid control is focused towards real robot exploitation in such a way to damp sudden changes of the torque commands and consequently, mechanical stress onto the thrust motors. The performance of the proposed control strategy and the comparison between sliding mode guidance, and sliding mode control embeds the neural dynamics model are described by a number of simulative tests. Moreover, measurement noises and a model of the sea currents variation, in direction and velocity, are counted in the simulated trials in order to demonstrate the control robustness with respect to measurement and environmental disturbances that unavoidably affect maritime operations.
Interaction with Mobile Devices and Work-Life Balance

This article will present the progress of my PhD course, now on its second year. The aim of the PhD is to understand the relationship between mo- bile technologies (enabling mobile working) and the Work-Life Balance (WLB). Through ethnographic research, the purpose is to identify the people's activities implemented to customize devices (particularly the smartphones) based on their WLB vision and environment interaction; but also identify meth- ods which could allow to understand the mobility aspect of new flexible work forms. The aim of the PhD is to provide input for user-oriented technologies de- sign based on the collected data that take into account the boundaries manage- ment in relation with individual and contextual factors, and identify a set of guidelines for management for implementing WLB policies.
Regulatory cross‐talk between adhesin operons in Escherichia coli: inhibition of type 1 fimbriae expression by the PapB protein

Pathogenic Escherichia coli often carry determinants for several different adhesins. We show a direct communication between two adhesin gene clusters in uropathogenic E.coli: type 1 fimbriae (fim) and pyelonephritis‐associated pili (pap). A regulator of pap, PapB, is a key factor in this cross‐talk. FimB recombinase turns on type 1 fimbrial expression, and PapB inhibited phase transition by FimB in both off‐to‐on and on‐to‐off directions. On‐to‐off switching requiring FimE was increased by PapB. By analysis of FimB– and FimE–LacZ translational fusions it was concluded that the increase in on‐to‐off transition rates was via an increase in FimE expression. Inhibition of FimB‐promoted switching was via a different mechanism: PapB inhibited FimB‐promoted in vitro recombination, indicating that FimB activity was blocked at the fim switch. In vitro analyses showed that PapB bound to several DNA regions of the type 1 fimbrial operon, including the fim switch region. These data show that Pap expression turns off type 1 fimbriae expression in the same cell. Such cross‐talk between adhesin gene clusters may bring about appropriate expression at the single cell level.
Automatic, localized in Vivo adjustment of all first‐and second‐order shim coils

The implementation of a “fast, automatic shimming technique by mapping along projections” (FASTMAP) on a 2.1‐Tesla whole‐body system is described. The method provides a localized adjustment of all first‐ (X, Y, Z) and second‐order (Z2, ZX, ZY, X2‐Y2, 2XY) coils in 2 min. The time savings are achieved by mapping the magnetic field along six projections rather than from whole‐imaging data sets. An analysis of noise error propagation suggests that in 64‐ml volumes the residual linewidths obtained with the method are negligible when the signal‐to‐rms‐noise ratio is above 30. The initial application of the method to localized 13C, 31P, and 1H spectroscopy of the human brain resulted in linewidths of ∼2 Hz for 13C (144‐ml volume), ∼2.5 Hz for 31P (36‐ml volume) and ∼4 Hz for 1H (36‐ml volume) with symmetric and reproducible lineshapes.
Course of Psychiatric Disorders across the Menstrual Cycle

&NA; Women of reproductive age with psychiatric disorders may experience a fluctuating course of illness over the menstrual cycle. Some data suggest an exacerbation of symptoms during the premenstrual and menstrual phases. The usefulness of such reports is limited, however, by the lack of prospective assessments and the small number of patients involved. Additionally, many reports do not specify whether the exacerbations reflect an intensification of the underlying psychiatric disorder or a new onset of symptoms that occur only during certain phases of the menstrual cycle. Because symptomatic intensification has been reported for illnesses including schizophrenia, bipolar disorder, depression, anxiety disorders, bulimia nervosa, and substance abuse, the data bring attention to the importance of assessing the relationship between a female patient's symptomatic exacerbation and the menstrual‐cycle phase in which it occurs. We present a review of the literature on the course of psychiatric symptoms across the menstrual cycle and discuss the potential effects of estrogen and progesterone on these symptoms.
Unawareness for Motor Impairment and Distorted Perception of Task Difficulty

Abstract Objectives: Anosognosia for motor impairment is a complex syndrome that can manifest itself under different forms, guiding patients’ behavior and task decisions. However, current diagnostic tools tend to evaluate only more explicit aspects of anosognosia (asking the patients about their motor abilities) and fail to address more subtle features of awareness. We have developed a new assessment measure, the ECT (Errand Choice Test), where patients are asked to judge task difficulty rather than estimate their own impairment. Methods: We assessed awareness in a group of 73 unilateral left- and right-brain damaged (30 LBD and 43 RBD, respectively) patients by means of the VATAm, which explicitly requires them to evaluate their own motor abilities, and the ECT. A control group of 65 healthy volunteers was asked to perform the ECT under two conditions: Current condition (i.e., using both hands) and Simulated conditions (i.e., simulating hemiplegia). Results: A total of 27% of the patients showed different performance on the VATAm and ECT, 21% of the patients showing lack of awareness only on VATAm and 6% only on ECT. Moreover, despite the ECT identified a higher frequency of anosognosia after RBD (33.3%) than LBD (27.6%), this hemispheric asymmetry was not significant. Remarkably, anosognosic patients performed very similarly to controls in the “current condition”, suggesting that anosognosic patients’ ability to perceive the complexity of each task per se is not altered. Conclusion: Different methods may be able to tackle different aspects of awareness and the ECT proved to be able to detect less evident forms of awareness. (JINS, 2018, 24, 45–56)
Development of resistance to 5-fluorocytosine in Candida parapsilosis during therapy.

After an initially favorable response, infective endocarditis caused by Candida parapsilosis recurred on day 37 of treatment with 5-fluorocytosine. Development of resistance of the organism to 5-fluorocytosine during therapy was documented by in vitro tests (MIC, 6.5 [tg/ml initially, > 129 ptg/ml after relapse). Although strains isolated before treatment and after relapse were able to incorporate exogenous uracil into RNA and were susceptible to 5-fluorouracil, the isolate found after relapse differed from the one isolated before treatment in being unable to incorporate exogenous cytosine and resistant to 5-fluorocytosine. The enzymatic basis of this resistance was identified as a virtual lack of cytosine deaminase activity in the strain isolated after relapse.
Exploring the Potential of a Novel Time Series Prediction Algorithm

We investigate the performance and applicability of an innovative and novel time series prediction technique, which differs greatly from conventional statistical and machine learning techniques such as ARIMA and artificial neural networks. This technique is a powerful, online and non-parametric learner. Details of the underlying algorithm are protected by an NDA. We initially develop an implementation of the technique which includes an intricate 3D visualisation of the underlying models and provides statistical functions and utilities which can be used to analyse the predictive power of the technique. We present a thorough analysis of the complexity and accuracy of these models tested on a range of artificial and real-world time series, with a strong emphasis on non-linear chaotic time series which are known to be very difficult to predict. Benchmark chaotic systems such as the Mackey-Glass series and the Lorenz system are among those analysed. The predictor’s ability to handle noisy data is also studied. The predictions made by the novel technique are compared with those made by current state-of-the-art machine learning techniques in particularly the multi-layer perceptron and the support vector machine. We find that the algorithm generally constructs good models which capture the periodicity of periodic series and the determinism in chaotic systems. Our experiments show that the algorithm is often able to give more accurate predictions than a basic multi-layer perceptron or support vector machine however this is dependent on the series. The algorithm’s ability to perform single-step prediction is particularly strong, whereas we find its multi-step prediction capability to be limited and problematic. In the presence of noisy data, we find that the models produced are not always optimal. When compared with the results of recent literature we find that the algorithm performs better than statistical methods such as exponential smoothing and ARIMA, however adaptations of the neural network model can outperform the algorithm in some cases.
Wireless dry-contact biopotential electrode

A wireless ECG/EEG system using dry-contact electrodes is presented. The system consists of a pair of coin sized dry-contact electrodes manufactured on a standard printed circuit board that can operate both on top of the skin and through clothing. A wearable wireless base unit assures the transmission of the ECG/EEG signals to a computer for storage and processing. Each electrode provides a differential gain of 60dB or 80dB over a 0.7–150Hz bandwidth with a noise level of 0. 8µV RMS and can be embedded within comfortable layers of fabric. Signals are digitized at the base unit by a 13-bit differential input ADC. The system is ideally suited for integration in wearable ECG chest harness or an EEG headband and can be used to monitor patient cardiac and neural signals in real time at home or in health care facilities. The preliminary results show that the proposed dry-contact electrode performs comparable to Ag/AgCl electrodes using either double sided adhesive disks, chest harness or headband for movement-free attachment.