Miracle-dz/UniFAR-FTUs huggingface dataset:
Regeneration is a partial redeployment of the embryonic gene network

For more than a century, researchers have been trying to understand the relationship between embryogenesis and regeneration (Morgan 1901). A long-standing hypothesis is that biological processes originally used during embryogenesis are re-deployed during regeneration. In the past decade, we have begun to understand the relationships of genes and their organization into regulatory networks responsible for driving embryogenesis (Davidson et al. 2002; Röttinger et al. 2012) and regeneration (Srivastava et al. 2014; Lobo and Levin 2015; Rodius et al. 2016) in diverse taxa. Here, we compare these networks in the same species to investigate how regeneration re-uses genetic interactions originally set aside for embryonic development. Using a uniquely suited embryonic development and whole-body regeneration model, the sea anemone Nematostella vectensis, we show that at the transcriptomic level the regenerative program partially re-uses elements of the embryonic gene network in addition to a small cohort of genes that are only activated during regeneration. We further identified co-expression modules that are either i) highly conserved between these two developmental trajectories and involved in core biological processes or ii) regeneration specific modules that drive cellular events unique to regeneration. Finally, our functional validation reveals that apoptosis is a regeneration-specific process in Nematostella and is required for the initiation of the regeneration program. These results indicate that regeneration reactivates embryonic gene modules to accomplish basic cellular functions but deploys a novel gene network logic to activate the regenerative process.
Five Principles for MOOC Design: With a Case Study

New web technologies have enabled online education to take on a massive scale, prompting many universities to create massively open online courses (MOOCs) that take advantage of these technologies in a seemingly effortless manner. Designing a MOOC, however, is anything but trivial. It involves developing content, learning activities, and assessments to accommodate both the massiveness and openness of the course. To design an effective MOOC, instructors need to integrate both pedagogical and information systems theory. In this paper, we present a case study of a MOOC grant and a series of decisions made in its development. These decisions, when paired with the theoretical framework, suggest five principles – meaningful, engaging, measurable, accessible, and scalable – may be applicable to future MOOC development projects.
Two new Afrotropical genera of Anthomyzidae (Diptera), with descriptions of seven new species

Barbarista gen. n. is established for five new species from tropical Africa, viz. B. guttata (type species, Kenya), B. pauperis (male only, Cameroon), B. brevifrons (Uganda), B. brachycera (Nigeria) and B. davidi (female only, Zimbabwe). The closely related genus Amnonthomyza gen. n. is descriptionbed to include two new species from Madagascar, viz. A. regina (type species) and A. deplanata (male only). Both new genera are diagnosed and their relationships discussed. They are considered to be closely allied taxa, probably derived from the same stock as Anthomyza FallA©n, 1810. Full descriptionptions of all species are given and their affinities discussed. Eggs of three Barbarista species are descriptionbed. All species are keyed and male and female genitalia are illustrated.
Aplicación de la toxina botulínica A para el tratamiento del síndrome de Frey

El sindrome Auriculo-temporal tambien conocido como sudoracion gustativa o sindrome de Frey, es una entidad caracterizada por sudoracion y enrojecimiento de la piel del territorio inervado por el nervio auriculo-temporal durante las comidas. El sindrome de Frey es probablemente una secuela inevitable en la cirugia de la glandula parotida. Una vez que se presenta se perpetua durante toda la vida si no se realiza tratamiento. Realizando el test de Minor tras cirugia sobre la glandula parotida ha sido publicado que el 100% son positivos, y que el 50% son sintomaticos percibiendo la sudoracion durante las comidas, y alrededor de un 15% consideran sus sintomas graves. En el siguiente articulo presentamos los resultados de nuestro estudio que consistio en la inyeccion intradermica de toxina botulinica A a nuestros pacientes con sindrome de Frey y el seguimiento. Los resultados han sido desaparicion de los sintomas durante un periodo medio de 16 meses con cierta variabilidad individual. Con estos resultados podria considerarse la inyeccion de toxina botulinica A como tecnica de eleccion para el sindrome de Frey ya establecido.
Good manufacturing practice in respect of medicinal products for human use and investigational medicinal products for human use

(3) Article 13(3) of Directive 2001/20/EC of the European Parliament and of the Council of 4 April 2001 on the approximation of the laws, regulations and administrative provisions of the Member States relating to the implementation of good clinical practice in the conduct of clinical trials on medicinal products for human use (4) requires that detailed guidance be drawn up, in accordance with the guidelines on good manufacturing practice, on the elements to be taken into account when evaluating investigational medicinal products for human use with the object of releasing batches within the Community.
A simple method to estimate the probable distribution of species

Species distribution models (SDMs) are broadly used to predict species distributions from available presence data. However, SDMs results have been criticized for several reasons mainly related to two basic characteristics of most SDMs: 1) general lack of reliable species absence information, 2) the frequent use of an arbitrary geographical extent (GE) or accessible area of the species. These impediments have motivated us to generate a procedure called niche of occurrence (NOO). NOO provides the probable distribution of species (realized niche) relying solely on partial information about presence of species. It operates within a natural geographical extent delimited by available observations and avoids using misleading thresholds to obtain binary presence–absence estimations when the species prevalence is unknown. In this study the main characteristics of NOO are presented, comparing its performance with other recognized and more complex SDMs by using virtual species to avoid the omnipresent error sources of real data sets.
De Røde Skoene - et kunstnerisk og teoretisk forskningsprosjekt om teater for de aller minste

This work presents an artistic research project on theatre for the very young (0-3 years old), in which the researcher was the artistic director. As an artist and researcher Lise Hovik investigated the theatre event through three different artistic contexts (performance, installation and improvised dance concert). The children were given the opportunity to play and interact with the performers during the shows, and caused a wide range of different forms of interaction and improvisation between the performers and children.The theatre events, which were documented with pictures, video, research conversations and written texts, constituted a diverse research material. In the research anaysis, which was mainly based on performative aesthetics, the significance of presence was emphasized. Actually being present in the live theatre event, the performers’ bodily presence, and the making presence in children’s playing were evident findings. Further the significance of musical communication was studied more closely. In the last phase of the research process the researcher conducted artistic experiments with different forms of interactive dramaturgy in which the relation between free playing and composed elements were put on stage. The multiple practice perspectives concerning the children, adults, performers, director and researcher called for new and critical methodology developed within the field of artistic research.As a scientific research project The Red Shoes Project has stepped on the borders between theory and practice, science and art. A clear focus, delimited research questions and a theoretically based perspective is in this project intersected with a practice-based and performative perspective, in which performance experiences and artistic reflections play a crucial part.The artistic and scientific result, in the shape of a series of performances and an article-based thesis, can be described as a meeting place between playing, art, theory and reflection on which the concepts and experiences of bodily, affective and musical communication are articulated and developed.
Creating New Medical Ontologies For Image Annotation A Case Study

Thank you for downloading creating new medical ontologies for image annotation a case study. As you may know, people have search numerous times for their favorite readings like this creating new medical ontologies for image annotation a case study, but end up in malicious downloads. Rather than reading a good book with a cup of coffee in the afternoon, instead they cope with some infectious virus inside their computer.
Control of Discrete Event Systems Using Condition/Event Nets and Partial Languages

In order to construct a rational framework of designing discrete event control systems, it is necessary to develop the method of modeling concurrent systems, describing control objectives, and synthesizing controllers based on the plant models and control objectives. If the control of discrete events is viewed as the manipulation of event occurrences, the role of a controller is to enable and inhibit the occurrences of events. This paper presents a framework for control of discrete event systems so as to achieve the desired behavior specified as a control objective. For this purpose, by using condition/event nets (C/E nets) as a modeling tool for discrete event systems and partial languages as a behavioral description tool for C/E nets, we formulate a control problem to synthesize a controller which guarantees that all and only the desired behaviors described by a partial language is possible. We then present the solvability and solution techniques of the formulated problem, together with the discussion about the design of discrete event control systems with uncontrollable and unobservable events.
A comparison of two multiple access protocols for voice transmission in personal communication networks

An important feature of modern mobile radio communications systems is that speech gaps during conversations are detected by speech codecs and that they are not coded into packets. This can help to decrease the number of transmitted data packets to about 50%. A main advantage is that the power consumption of a (handheld) terminal decreases accordingly. Although this technique has already been applied to several systems, there is yet a lack of protocols for PCNs that assign the unused radio channels to other connections when there is a speech gap detected. The authors compare two multiple access protocols that try to overcome this problem. The first protocol is the well known packet reservation multiple access (PRMA) and the second is a protocol of the class of demand assignment multiple access (DAMA) with explicit reservations. It comes out that the latter may perform better when it is well engineered. <<ETX>>
Interaction of sinking behaviour of Saharan dust and lithogenic and biogenic fluxes in the Canary Basin

Saharan dust events are currently the predominant source of lithogenic particles in the Canary Basin. In order to quantify this input and its relationship with the biogenic fluxes, a sediment trap was deployed in a free-drifting system at 150 m depth, 50 km off the north coast of Gran Canaria (Canary Islands). The mineralogy of the lithogenic particles included illite, calcite, hematite quartz, barite and kaolinite. The biogenic matter was composed of chitin, transparent exopolymer particles, and carbonates from foraminifera and gastropod shells. The average Saharan dust flux over the ocean surface was approximately 5±4 mg m–2 day-1. The lithogenic, carbonate and chitin fluxes were 0.8±0.6, 6.0±7.4 and 154±386 mg m–2 day-1, respectively. A fairly strong Saharan dust event during sampling was observed in the trap, with a delay of three days in the peaks of lithogenic and biogenic fluxes. The theoretical settling velocity of the lithogenic particles associated with Saharan dust events at 150 m depth was vStokes=275 m day-1, and the experimental settling was about 50 m day-1. The associated sinking behaviour of particulate organic carbon and biogenic and lithogenic fluxes observed in this study may contribute to a more realistic prediction of these fluxes in carbon biological pump models.
Adaptive hyperspectral small-target detection

A novel adaptive multilevel classification and detection method that takes into account both spectral and spatial characteristics of the data is proposed. Principal clusters are defined first, and those include background clusters and the predefined target clusters. The classification is done using minimum distance statistical classifier. Here, the main concern is to minimize misclassification rate, by allowing a number of pixels for which the classification confidence is low to remain unclassified at this level. The candidate clusters that are used in the analysis for the unclassified pixels are defined next. The candidate clusters are determined from both the spatial and spectral neighborhoods, using the labels of already classified pixels. Using defined candidate clusters, the mixing model analysis is performed. The linear least squares method to determine the fractions of particular candidate clusters in the corresponding pixel is applied. The results of the mixing model analysis are checked, and if the results of the analysis are satisfactory, the next step is performed. If the results of the analysis are not satisfactory, the candidate clusters list is renewed. After the loop processing has been completed for all pixels in the image, the target detection is performed. That process is based on comparing the estimated quantity of the pixels target endmember and the predefined thresholds. At the end, the detected targets are clustered, and their parameters are estimated. The proposed method was successfully applied to both synthetic and AVIRIS hyperspectral images of the Naval Air Station Fallon.
Faking It: The Quest for Authenticity in Popular Music

In the last fifty years, the quest for authenticity, for the 'real', has become a dominant factor in musical taste - whether it be the folklorist's search for forgotten bluesmen, the rock critic's elevation of raw power over sophistication, or the importance of bullet wounds to the careers of hip-hop artists such as 50 Cent. "Faking It" explodes the myth of what it means to be 'real' and 'fake' in pop music. From 30s blues singer Leadbelly to Moby's use of his singing over half a century later, the appropriation of black music by a predominantly white musical fanbase, Pop Idol, the fact that no one in Cuba listens to Buena Vista Social Club to Kurt Cobain's suicide note and the fear it expressed of 'faking it'.
Disappearance of Triallate from Field Soils

Small field plots, 18 by 18 cm in size, were treated with S-(2,3,3-trichloroallyl)diisopropylthiolcarbamate (triallate) at rates equivalent to 2.8 kg/ha at five sites in Saskatchewan. After one growing season (5 months) the residues remaining in the 0 to 5 and 5 to 10-cm levels of soil were determined by gas chromatographic analysis. At all locations 16 to 27% of the applied herbicide was found in the top 5 cm while negligible residues were detected at the 5 to 10-cm level.
Modélisation numérique des structures composites multicouches à l’aide d’une approche discrète au sens de Mindlin. Le modèle DDM (Displacement Discrete Mindlin)

Ce travail de these consiste le developpement d’un element fini de plaque et de coque courbe geometriquement simple (4 nœuds), base sur une nouvelle approche variationnelle appelee DDM (Displacement Discrete Mindlin). Il prend en compte l’effet du cisaillement transversal CT a travers l’epaisseur. Le modele DDM introduit de maniere discrete deux hypotheses de Mindlin. La premiere hypothese est cinematique, elle consiste a introduire sous la forme d’une integrale de contour une equation cinematique de la deformation de CT. Elle permet l’elimination du verrouillage en CT sans introduire des fonctions bulles ou sans recourir a l’integration reduite ou selective. Il s’agit de l’approche des deformations de CT de substitution, connue sous le nom de « ANS method : Assumed Natural Strains ». La seconde hypothese fait appel a deux lois de comportement, l’une en flexion et l’autre en CT, et deux equations d’equilibre d’une plaque en flexion/CT. Elle a pour principal avantage une elimination locale des degres de libertes de rotation, introduits initialement au milieu d’un bord elementaire par le biais d’une approximation quadratique des rotations de la normale a la surface moyenne
Factors that Motivate Participation in Observational Genetic Cancer Research Studies

Demographics, access to new treatment, altruistic motivations and continuity of care have been shown to influence motivation to participate in clinical trials. Less is known however, about factors that motivate research participants to agree to take part in observational studies and provide a biologic specimen. This study evaluates and quantitates factors that motivate participation in observational studies and provide a biospecimen among cancer patients, their family members, and controls. An online survey was completed by 450 participants from a cancer genetics registry, including cancer patients, their relatives, and controls. Overall, the benefit to society and the research institution reputation were the most important motivators for participation. Cancer cases were significantly more likely to endorse personal meaningfulness as a factor for participation compared to those without cancer and women were 50% more likely than men to believe that a family benefit is an important determinant of research participation. Researcher and institutional trustworthiness as well as security of stored data were most important when deciding whether to provide a biological sample, with differences seen by gender and history of cancer. This study demonstrated which factors are most important to participants when considering participation in an observational study and donating a biospecimen. Motivational factors significantly differed by gender as well as history and stage of cancer. The application of these study results may improve participation rates in cohort studies.
Kibitz : a framework for creating recommender systems

Recommender systems are one of the most vital and ubiquitous parts of the modern web. They are used by many major internet services such as Facebook, Google, and Amazon. However, there is a wealth of content and data that remains untapped by mainstream commercial recommender systems. We have designed and implemented Kibitz, a framework that allows anyone to create a recommender system on top of an arbitrary collection of items. We have developed a web application that facilitates the creation, customization and deployment of standalone websites for browsing and rating items as well as receiving item recommendations. We have also created a set of libraries for embedding rating and recommendation functionality into other websites. Partnering with local bookstores, we evaluated the process of using Kibitz to build recommender systems for their communities. Thesis Supervisor: David R. Karger Title: Professor
Ranking Software Artifacts

Reengineering and integrated development plat- forms typically do not list search results in a particularly useful order. PageRank is the algorithm prominently used by the Google internet search engine to rank the relative importance of elements in a set of hyperlinked documents. To determine the relevance of objects, classes, attributes, and methods we propose to apply PageRank to software artifacts and their relationship (reference, inheritance, access, and invocation). This paper presents various experiments that demonstrate the usefulness of the ranking algorithm in software (re)engineering.
Deep learning segmentation of kidneys with renal cell carcinoma.

e16098 Background: Renal cell carcinoma (RCC) is the most common kidney malignancy and the eighth most common cancer overall, with more than 60,000 new cases and nearly 15,000 deaths in the United States each year. The majority of RCC is asymptomatic and detected incidentally on computed tomography (CT) scans performed for other indications. Multiple prior studies have highlighted the potential for a lesion to be missed or mischaracterized. Artificial intelligence (AI), the mimicking of human cognition by computers, has promise for improving radiological accuracy. Convolutional neural networks (CNNs), a type of AI, apply a feed-forward design to an artificial neural network. Multi-layered CNNs thus have application in biomedical imaging and radiology. In this study we describe an approach for automatic localization and segmentation of the kidneys on contrast enhanced CT scan. Methods: This IRB approved retrospective study included patients who were diagnosed with RCC and had an abdominal CT scan with IV contrast from 2011 to 2019. For each abdominal CT scan, the kidneys and any renal lesions were manually segmented by a board-certified abdominal radiologist on the coronal post-contrast phase of the CT scan. Two CNNs were developed and trained to segment the kidneys automatically. Initially, the CNN implemented a regression algorithm that predicted a 3D bounding box around each kidney. Subsequently, the second CNN used a 3D/3D U-Net algorithm that received the bounding cube as its input and outlined the kidney as an output. After training, the CNN algorithms were assessed by a Sørensen-Dice coefficient. Results: The first CNN that predicted a 3D bounding box around each kidney was trained on 127 abdominal CT exams. The second CNN that segmented the kidneys with RCC was trained on 259 bounding boxes that encompassed the kidneys. The Sørensen–Dice coefficient for segmentation of the kidneys with RCC was 0.92. Conclusions: These results demonstrate that two CNNs can be used in succession to segment the kidneys with RCC on a coronal CT image with high accuracy. Moreover, as the subjects included patients with RCC, medical renal disease, and cystic renal disease, the outcome further supports the role of CNN in evaluation of complex cases rather than pristine training sets. Future work will focus on segmentation of RCC lesions.