Miracle-dz/UniFAR-FTUs huggingface dataset:
PMSM model for sensorless control considering saturation induced secondary saliencies

Saliencies in electric machines are caused by the machine geometry and saturation. PMSM typically do not just show a single sinusoidal saliency, which is the main saliency utilized for position tracking. Secondary saliencies are a major source of deterioration for sensorless control, whereby saturation is reported to be the main problem. Cross-saturation, caused by a movement of the main flux away from the d-axis, results in steady-state position estimation errors. Moreover saturation can result in 6n-harmonic components in the inductances in field oriented coordinates. This effect causes position dependent estimation errors. Both effects need to be compensated for, if significant. For model based compensation a machine model with time-variant parameters is needed to cope with nonlinear material characteristics. A general machine model in field oriented coordinates considering multiple saliencies is derived and a method for systematic determination of the position dependent inductances is proposed. The machine model is verified by test bench measurement results.
Addressing the Consensus Problem in Real-time Using Lightweight Middleware on Distributed Devices

Addressing the Consensus Problem in Real-time Using Lightweight Middleware on Distributed Devices. (August 2011) Keith Anton Hall, B.S., Texas A&M University Chair of Advisory Committee: Dr. Abhijit Deshmukh With the advent of the modern technological age, a plethora of electronic tools and devices are available in numbers as never before. While beneficial and exceedingly useful, these electronic devices require users to operate them. When designing systems capable of observing and acting upon an environment, the number of devices can become unmanageable. Previously, middleware systems were designed for large-scale computational systems. However, by applying similar concepts and distributing logic to autonomous agents residing on the devices, a new paradigm in distributed systems research on lightweight devices is conceivable. Therefore, this research focuses upon the development of a lightweight middleware that can reside on small devices enabling the capability for these devices to act autonomously. In this research, analyses determine the most advantageous methods for solving this problem by defining a set of requirements for the necessary middleware as well as assumptions for the environment and system in which it would operate achieved a proper research focus. By utilizing concepts already in existence iv such as peer-to-peer networking and distributed hash tables, devices in this system could communicate effectively and efficiently. Furthermore, creating custom algorithms for communicating with other devices and collaborating on task assignments achieves an approach to solving the consensus problem in real time. The resulting middleware solution allows a demonstration to prove the efficacy. Using three devices capable of observing the environment and acting upon it, two tests highlight the capabilities of the consensus-finding mechanism as well as the ability of the devices to respond to changes in the environment autonomously.
Functional characterization of Vif proteins from HIV-1 infected patients with different APOBEC3G haplotypes

Objective:The human cytidine deaminase APOBEC3G (A3G) potently restricts HIV-1 but the virus, in turn, expresses a Vif protein which degrades A3G. A natural A3G-H186R variant, common in African populations, has been associated with a more rapid AIDS disease progression, but the underlying mechanism remains unknown. We hypothesized that differences in HIV-1 Vif activity towards A3G wild type and A3G-H186R contribute to the distinct clinical AIDS manifestation. Methods:Vif variants were cloned from plasma samples of 26 South African HIV-1 subtype C infected patients, which either express wild type A3G or A3G-H186R. The Vif alleles were assessed for their ability to counteract A3G variants using western blot and single-cycle infectivity assays. Results:We obtained a total of 392 Vif sequences which displayed an amino acid sequence difference of 6.2–19.2% between patients. The intrapatient Vif diversities from patient groups A3GWT/WT, A3GWT/H186R and A3GH186R/H186R were similar. Vif variants obtained from patients expressing A3GWT/WT and A3GH186R/H186R were capable of counteracting both A3G variants with similar efficiency. However, the antiviral activity of A3G-H186R was significantly reduced in both the presence and absence of Vif, indicating that the A3G-H186R variant intrinsically exerts less antiviral activity. Conclusion:A3G wild type and A3G-H186R are equally susceptible to counteraction by Vif, regardless of whether the Vif variant was obtained from A3GWT/WT and A3GH186R/H186R patients. However, the A3G-H186R variant intrinsically displayed lower antiviral activity, which could explain the higher plasma viral loads and accelerated disease progression reported for patients expressing A3GH186R/H186R.
Mathematik in den Naturwissenschaften Leipzig When Does a Mixture of Products Contain a Product of Mixtures ?

We derive relations between theoretical properties of restricted Boltzmann machines (RBMs), popular machine learning models which form the building blocks of deep learning models, and several natural notions from discrete mathematics and convex geometry. We give implications and equivalences relating RBM-representable probability distributions, perfectly reconstructible inputs, Hamming modes, zonotopes and zonosets, point configurations in hyperplane arrangements, linear threshold codes, and multi-covering numbers of hypercubes. As a motivating application, we prove results on the relative representational power of mixtures of product distributions and products of mixtures of pairs of product distributions (RBMs) that formally justify widely held intuitions about distributed representations. In particular, we show that a mixture of products requiring an exponentially larger number of parameters is needed to represent the probability distributions which can be obtained as products of mixtures.
Electrostatic painting of insulating surfaces

Techniques for painting insulating surfaces by electrostatic painting (a technique currently used to paint conducting objects, but not applicable to insulators) are discussed. Several ionizers have been tested, and good painting has been obtained, provided that the flows of paint and ionized air are well separated. The possibility of self-creation of ionized air by the voltage of the early paint deposit has also been successfully tested. <<ETX>>
Decreased Expression of ARV1 Results in Cholesterol Retention in the Endoplasmic Reticulum and Abnormal Bile Acid Metabolism*

Endoplasmic reticulum (ER) membrane cholesterol is maintained at an optimal concentration of ∼5 mol % by the net impact of sterol synthesis, modification, and export. Arv1p was first identified in the yeast Saccharomyces cerevisiae as a key component of this homeostasis due to its probable role in intracellular sterol transport. Mammalian ARV1, which can fully complement the yeast lesion, encodes a ubiquitously expressed, resident ER protein. Repeated dosing of specific antisense oligonucleotides to ARV1 produced a marked reduction of ARV1 transcripts in liver, adipose, and to a lesser extent, intestine. This resulted in marked hypercholesterolemia, elevated serum bile acids, and activation of the hepatic farnesoid X receptor (FXR) regulatory pathway. Knockdown of ARV1 in murine liver and HepG2 cells was associated with accumulation of cholesterol in the ER at the expense of the plasma membrane and suppression of sterol regulatory element-binding proteins and their targets. These studies indicate a critical role of mammalian Arv1p in sterol movement from the ER and in the ensuing regulation of hepatic cholesterol and bile acid metabolism.
A New Flavin Radical Signal in the Na+-pumping NADH:Quinone Oxidoreductase from Vibrio cholerae

The Na+-pumping NADH-ubiquinone oxidoreductase has six polypeptide subunits (NqrA–F) and a number of redox cofactors, including a noncovalently bound FAD and a 2Fe-2S center in subunit F, covalently bound FMNs in subunits B and C, and a noncovalently bound riboflavin in an undisclosed location. The FMN cofactors in subunits B and C are bound to threonine residues by phosphoester linkages. A neutral flavin-semiquinone radical is observed in the oxidized enzyme, whereas an anionic flavin-semiquinone has been reported in the reduced enzyme. For this work, we have altered the binding ligands of the FMNs in subunits B and C by replacing the threonine ligands with other amino acids, and we studied the resulting mutants by EPR and electron nuclear double resonance spectroscopy. We conclude that the sodium-translocating NADH:quinone oxidoreductase forms three spectroscopically distinct flavin radicals as follows: 1) a neutral radical in the oxidized enzyme, which is observed in all of the mutants and most likely arises from the riboflavin; 2) an anionic radical observed in the fully reduced enzyme, which is present in wild type, and the NqrC-T225Y mutant but not the NqrB-T236Y mutant; 3) a second anionic radical, seen primarily under weakly reducing conditions, which is present in wild type, and the NqrB-T236Y mutant but not the NqrC-T225Y mutant. Thus, we can tentatively assign the first anionic radical to the FMN in subunit B and the second to the FMN in subunit C. The second anionic radical has not been reported previously. In electron nuclear double resonance spectra, it exhibits a larger line width and larger 8α-methyl proton splittings, compared with the first anionic radical.
What moves a family doctor to specialise in HIV? Interviews with Australian policy key informants

The population of people living with HIV in Australia is increasing, requiring an expert primary care workforce to provide HIV clinical care into the future. Yet the numbers of family doctors or general practitioners (GPs) training as community-based HIV medication prescribers may be insufficient to replace those retiring, reducing hours or changing roles. We conducted semi-structured interviews between February and April, 2010, with 24 key informants holding senior roles in organisations that shape HIV-care policy to explore their perceptions of contemporary issues facing the HIV general practice workforce in Australia. Informed by interpretive description, our analysis explores how these key informants characterised GPs as being ‘moved’ by the clinical, professional and political dimensions of the role of the HIV general practice doctor. Each of these dimensions was represented as essential to the engagement of GPs in HIV as an area of special interest, although the political dimensions were often described as the most distinctive compared to other areas of general practice medicine. Our analysis explores how each of these dimensions contributes to shaping the contemporary culture of HIV medicine and suggests that such an approach could be useful for understanding how health professionals become engaged in other under-served areas of medical work.
Incidence and Characteristics of Atypical Femoral Fractures: Clinical and Geometrical Data

Despite the multitude of studies published on atypical femoral fractures (AFFs), a profile for patients at risk does not exist. This study aimed first at estimating AFF incidence over a 19‐month‐period in Quebec City using the ASBMR Task force criteria to define AFF. The medical records of patients hospitalized for hip or femoral fracture between June 1, 2009, and December 31, 2010, were reviewed. Thirty‐six cases of atypical fractures were identified during the 19‐month period, representing an AFF incidence of 7.0 (range, 4.7 to 9.3) cases per 100,000 person‐years. In the second part of the study, data regarding the characteristics suspected of increasing the risks of AFF were collected from medical and pharmacological records, proximal femur radiographs, and patient interviews. The data regarding each patient with an AFF during years 2008‐2011 were compared to two controls with a hip or femoral fragility fracture or a traumatic fracture, paired for age and sex. Twenty patients with AFF were added to the 36 patients with AFF selected in the first part, thereby 56 patients with AFF were investigated. The association between the occurrence of AFF and bisphosphonates (BPs) use was proven statistically significant in multivariate analysis, odds ratio (OR) = 10.39 (95% CI, 2.22 to 48.58; p = 0.0029). Compared to controls, patients with AFF had excessive femoral offset (43.1 mm versus 38.3 mm, p = 0.0007), proximal femoral neck angle in varus (128.9 degrees versus 134.0 degrees, p < 0.0001), and had greater proximal cortical thickness. This retrospective study confirms the low incidence of AFF, confirms its significant association with exposure to BPs, and reveals the possible contribution of proximal femoral geometry in AFF occurrence. © 2016 American Society for Bone and Mineral Research.
Macrocephaly‐cutis marmorata telangiectatica congenita: Report of six new patients and a review

We report on six additional patients with macrocephaly‐cutis marmorata telangiectatica congenita (M‐CMTC; MIM 602501) and review the literature. This syndrome is a multiple congenital anomalies/mental retardation and overgrowth disorder comprising macrocephaly, cutis marmorata, vascular marks of lip and/or philtrum, syndactyly, hemihypertrophy, CNS anomalies, and developmental delay. Based on the findings in our 6 patients and on 69 patients previously reported we listed the very frequent (observed in >75%), frequent (25–75%), and less frequent (>25%) components of the syndrome. © 2004 Wiley‐Liss, Inc.
Interannual Variability in the Southern Hemisphere Circulation Organized by Stratospheric Final Warming Events

Abstract A composite observational analysis is presented demonstrating that austral stratospheric final warming (SFW) events provide a substantial organizing influence upon the large-scale atmospheric circulation in the Southern Hemisphere. In particular, the annual weakening of high-latitude westerlies in the upper troposphere and stratosphere is accelerated during SFW onset. This behavior is associated with a coherent annular circulation change with zonal wind decelerations (accelerations) at high (low) latitudes. The high-latitude stratospheric decelerations are induced by the anomalous wave driving of upward-propagating tropospheric waves. Longitudinally asymmetric circulation changes occur in the lower troposphere during SFW onset with regionally localized height increases (decreases) at subpolar (middle) latitudes. Importantly, the tropospheric and stratospheric circulation change patterns identified here are structurally distinct from the Southern Annular Mode. It is concluded that SFW events are l.
Functional organization of rat olfactory bulb analysed by the 2‐deoxyglucose method

The spatial patterns of activity elicited in the rat olfactory bulb under different odor conditions have been analysed using the 2‐deoxyglucose (2DG) technique. Rats were injected with 14C‐2DG, exposed to controlled environments of amyl acetate, camphor, cage air, dimethyl disulfide, and pure air and autoradiographs prepared by the method of Sokoloff. Amyl acetate was associated with regions of glomerular layer densities in the anterolateral and mid‐ to posteromedial parts of the bulbar circumference, as previously reported. The extents of the densities increased with increasing concentration. Camphor odor was associated with regions of increased density in the anterodorsal and mid‐ to posteromedial parts of the bulb. Exposure to cage air produced scattered densities in the posteromedial and posterolateral bulb. Exposure to dimethyl disulfide gave variable results. Pure air was associated with a minimal number of small dense foci.
Numb Regulates the Polarized Delivery of Cyclic Nucleotide-Gated Ion Channels in Rod Photoreceptor Cilia

The development and maintenance of protein compartmentalization is essential for neuronal function. A striking example is observed in light-sensing photoreceptors, in which the apical sensory cilium is subdivided into an inner and outer segment, each containing specific proteins essential for vision. It remains unclear, however, how such polarized protein localization is regulated. We report here that the endocytic adaptor protein Numb localizes to the inner, but not the outer segment of mouse photoreceptor cilia. Rod photoreceptor-specific inactivation of numb in vivo leads to progressive photoreceptor degeneration, indicating an essential role for Numb in photoreceptor cell biology. Interestingly, we report that loss of Numb in photoreceptors does not affect the localization of outer segment disk membrane proteins, such as rhodopsin, Peripherin-rds, Rom-1, and Abca4, but significantly disrupts the localization of the rod cyclic nucleotide-gated (Cng) channels, which accumulates on the inner segment plasma membrane in addition to its normal localization to the outer segments. Mechanistically, we show that Numb interacts with both subunits of the Cng channel and promotes the trafficking of Cnga1 to the recycling endosome. These results suggest a model in which Numb prevents targeting of Cng channels to the inner segment, by promoting their trafficking through the recycling endosome, where they can be sorted for specific delivery to the outer segment. This study uncovers a novel mechanism regulating polarized protein delivery in light-sensing cilia, raising the possibility that Numb plays a part in the regulation of protein trafficking in other types of cilia.
Applying Technology to Crisis Mapping and Early Warning in Humanitarian Settings

Le but de ce document de travail est d'analyser brievement l'utilisation actuelle et l'evolution du role des technologies de l'information et de la communication (TIC) dans les alertes rapides en cas de conflit, dans la cartographie en cas de crise ("crisis mapping") et la reponse humanitaire. Le document donne d'abord quelques exemples de TIC en action, puis analyse les enjeux et les potentielles solutions de l'utilisation des TIC dans les situations de crise.
Calibration of 6q subtelomere deletions to define genotype/phenotype correlations

Testing for subtelomere abnormalities in patients with idiopathic mental retardation has become a useful diagnostic tool. However, limited data exist regarding genotype/phenotype correlations for specific subtelomere imbalances. We have ascertained five patients with 6q subtelomere deletions either as a result of an isolated deletion or as a result of an unbalanced translocation, and developed a molecular ruler assay utilizing BAC or PAC clones and determined the size of the deleted regions to range from <0.5 to 8 Mb. To establish genotype/phenotype correlations for distal 6q, we compared the clinical features of these patients to previously reported cases of 6q subtelomere and cytogenetically visible deletions and found that they shared multiple abnormalities, suggesting that the causative genes may lie in the region of the smallest 6q subtelomeric deletion, approximately 400 kb from the telomere. However, multiple unique features were present only in patients with cytogenetically visible 6q deletions, indicative that genes involved in the development of these features may lie more proximally on 6q. These initial studies demonstrate the ability to develop genotype/phenotype correlations for subtelomere rearrangements, which will aid in the diagnosis and prognosis of these patients and may help narrow the search for relevant developmental genes.
Semimetallic dense hydrogen above 260 GPa

Being the lightest and the most abundant element in the universe, hydrogen is fascinating to physicists. In particular, the conditions of its metallization associated with a possible superconducting state at high temperature have been a matter of much debate in the scientific community, and progress in this field is strongly correlated with the advancements in theoretical methods and experimental techniques. Recently, the existence of hydrogen in a metallic state was reported experimentally at room temperature under a pressure of 260–270 GPa, but was shortly after that disputed in the light of more experiments, finding either a semimetal or a transition to an other phase. With the aim to reconcile the different interpretations proposed, we propose by combining several computational techniques, such as density functional theory and the GW approximation, that phase III at ambient temperature of hydrogen is the Cmca-12 phase, which becomes a semimetal at 260 GPa . From phonon calculations, we demonstrate it to be dynamically stable; calculated electron–phonon coupling is rather weak and therefore this phase is not expected to be a high-temperature superconductor.
High‐resolution structures of formate dehydrogenase from Candida boidinii

The understanding of the mechanism of enzymatic recovery of NADH is of biological and of considerable biotechnological interest, since the essential, but expensive, cofactor NADH is exhausted in asymmetric hydrogenation processes, but can be recovered by NAD+‐dependent formate dehydrogenase (FDH). Most accepted for this purpose is the FDH from the yeast Candida boidinii (CbFDH), which, having relatively low thermostability and specific activity, has been targeted by enzyme engineering for several years. Optimization by mutagenesis studies was performed based on physiological studies and structure modeling. However, X‐ray structural information has been required in order to clarify the enzymatic mechanism and to enhance the effectiveness and operational stability of enzymatic cofactor regenerators in biocatalytic enantiomer synthesis as well as to explain the observed biochemical differences between yeast and bacterial FDH. We designed two single‐point mutants in CbFDH using an adapted surface engineering approach, and this allowed crystals suitable for high‐resolution X‐ray structural studies to be obtained. The mutations improved the crystallizability of the protein and also the catalytic properties and the stability of the enzyme. With these crystal structures, we explain the observed differences from both sources, and form the basis for further rational mutagenesis studies.