Miracle-dz/UniFAR-FTUs huggingface dataset:
Preliminary Exploration of the Relationship between Uterine Position and Meridian Point Effect Specificity in Primary Dysmenorrhea Patients

Objective To explore the relationship between uterine position and meridian point effect specificity by analyzing the data related to a multicenter randomized controlled trial of electroacupuncture treatment for primary dysmenorrhea. Methods Three hundred and sixty-eight patients with primary dysmenorrhea were given an assessment of the uterine position and acupuncture treatment. Pain severity was quantitatively assessed using the Visual Analogue Scale(VAS) in the patients at various time points before and after treatment. Analysis of variance was used for the data from multi-group repeated measures designs. Results The VAS score tended to decrease over time within one hour of observation in every group of patients with anteposition of uterus. There was no statistically significant difference in the VAS score between various groups(P0.05). The results in the patients with middle position or retroposition of uterus were similar to those in the patients with anteposition of uterus. Conclusion The existing results can not yet show the correlation between uterine position and meridian point effect specificity.
Global optimisation and mobile learning

Mobile devices, such as cellular phones and Personal Digital Assistants (PDA), have become part and parcel of our everyday life. These mobile technologies and their wide adoption in the society are influencing not only the way we live, but also the way we learn, the way we work, and the way we socialise. According to [1], there are estimated to be more than 1.5 billion mobile phones in the world today.
Insects and the Evolution of Developmental Pathways: Functional Analysis of Genetic Sex Determination Mechanisms in Oncopeltus fasciatus

5 ACKNOWLEDGEMENTS . 6 CHAPTER ONE: INTRODUCTION . 8 1.1 Sex Determination and the Evolution of Developmental Pathways . 8 1.2 Sex Determination in Drosophila melanogaster and other Insects . 13 1.3 Oncopeltus fasciatus as an Outgroup Organism in Sex Determination Studies . 17 1.4 Sexual Dimorphisms of Oncopeltus fasciatus . 18 1.5 Studying the Sex Determination of Oncopeltus fasciatus . 21 CHAPTER TWO: MATERIALS AND METHODS . 29 2.1 Lab rearing of O. fasciatus populations . 29 2.2 Phylogenetic study of ix, fru, and dsx sequence orthology between O. fasciatus and other Hemiptera as well as Holometabola . 29 2.3 qRT-PCR studies of ix, dsx-a, dsx-b, and dsx-c expression during O. fasciatus development . 30 2.3.1 O. fasciatus specimens RNA extractions . 30 2.3.2 Dual-label qRT-PCR studies of gene expression during O. fasciatus development . 31 2.4 RNAi studies of ix, fru, dsx-a, dsx-b, and dsx-c function in O. fasciatus sex determination and development . 31 2.4. 1 Double-stranded RNA synthesis . 32 2.4. 2 Injection of O. fasciatus . 33 2.4. 3 Imaging of O. fasciatus RNAi specimens for morphological phenotype analysis . 36 2.4. 4 Verification of RNAi treatments and study of sex determination gene interactions via qRTPCR measurements of gene expression . 36 2.5 Morphological analysis of RNAi phenotypes . 37 2.5. 1 Analysis of O. fasciatus specimens genitalia . 37 2.5. 2. Analysis of O. fasciatus abdominal sternite curvature . 37 2.5. 3 Analysis of O. fasciatus head shape . 38 2.6 Statistical Analyses . 41 CHAPTER THREE: RESULTS AND DISCUSSION . 42 3.1 Phylogenetic study of ix, fru, and dsx sequence . 42 3.1.1 The intersex protein tree recapitulates species relationships . 42 3.1.2 The fruitless protein tree recapitulates species relationships . 44 3.1.3 Phylogeny of doublesex proteins shows clustering of orthologs . 46 3.2 Increased ix, dsx-a, dsx-b, and dsx-c expression during the fifth instar and adulthood in both female and male bugs . 48 3.3 RNA interference effects on development of sexually dimorphic structures . 52 3.3.1 RNAi effects on genitalia development in female and male O. fasciatus . 52 3.3.2 RNAi effects on sternite curvature in female and male O. fasciatus . 56 3.3.3 RNAi produced different combinations of impaired genitalia and/or sternite development . 59 3.4 qRT-PCR examining gene interactions and RNAi validation . 62
Huaier polysaccharide inhibits the stem-like characteristics of ERα-36high triple negative breast cancer cells via inactivation of the ERα-36 signaling pathway

Triple negative breast cancer (TNBC) is a highly aggressive cancer and lack of targeting therapies. It is believed that the breast cancer stem cells (BCSCs) are responsible for the aggressive characteristics of TNBC. Hence, developing BCSC-targeting agents may provide new therapeutic strategies for the patients. Huaier polysaccharide (HP), an active ingredient extracted from the mushroom Trametes robiniophila Murr, has been widely used in clinical anti-cancer treatments in China. Here we demonstrated that HP could target BCSCs in TNBC cells, resulting in decreased mammosphere formation, downregulated expression of stem-related genes and reduced proportion of aldehyde dehydrogenase positive cells in vitro, and inhibited xenograft tumor formation in vivo. Mechanically, HP markedly reduced the expression of estrogen receptor α-36 (ERα-36), a recently identified subtype of estrogen receptor α, and attenuated ERα-36-mediated activation of AKT/β-catenin signaling in ERα-36high TNBC cells. This study provides a new insight into the mechanism of HP on BCSC-targeting therapy and new ideas for comprehensive treatment strategies for TNBC.
QoS Composition and Decomposition Model in Uniframe

Abstract : Software systems are increasingly large, complex, heterogeneous, distributed and pervasive. The component-based software development provides a promising methodology for developing large-scale, complex software systems. Component-based software development advocates developing software systems by selecting commercial-off-the-shelf or in-house software components and assembling them within appropriate software architectures. This software development methodology promises software reuse and thus increases development is the prediction of the system quality attributes in the absence of implementation details of individual software components. In top-down development, it is critical to factor the system level quality attributes into individual components, and thus facilitate the selection of qualified components. In bottom-up development, it is important to predict the system wide quality attributes based on the quality attributes of individual components and the way they compose. This thesis proposes an approach for decomposing and composing quality of service parameters during development of component-based software systems. The inter-component communication patterns are identified and their effects on the composition and decomposition of QoS parameters are studied. The effect of the network and the execution environment on the composition and decomposition of QoS parameters are preliminarily investigated.
3D RECONSTRUCTION USING MULTI- VIEW IMAGING SYSTEM

OF THESIS 3D RECONSTRUCTION USING MULTI-VIEW IMAGING SYSTEM This thesis presents a new system that reconstructs the 3D representation of dental casts. To maintain the integrity of the 3D representation, a standard model is built to cover the blind spots that the camera cannot reach. The standard model is obtained by scanning a real human mouth model with a laser scanner. Then the model is simplified by an algorithm which is based on iterative contraction of vertex pairs. The simplified standard model uses a local parametrization method to obtain the curvature information. The system uses a digital camera and a square tube mirror in front of the camera to capture multi-view images. The mirror is made of stainless steel in order to avoid double reflections. The reflected areas of the image are considered as images taken by the virtual cameras. Only one camera calibration is needed since the virtual cameras have the same intrinsic parameters as the real camera. Depth is computed by a simple and accurate geometry based method once the corresponding points are identified. Correspondences are selected using a feature point based stereo matching process, including fast normalized cross-correlation and simulated annealing.
Hydraulics of European beech and Norway spruce under experimental drought

Drought responses, hydraulic acclimation and embolism repair potential were investigated in European beech and Norway spruce trees. In adult trees subjected to through-fall exclusion over two years, acclimation of branch and leaf hydraulic traits was found in both species. In drought-irrigation cycles in potted saplings, embolism dynamics were related to stem non-structural carbohydrate content: only spruce recovered stem hydraulic function upon drought stress relief, which was connected to carbohydrate depletion.
Computer interfacing of a microwave resonant cavity for temperature measurements during dielectric relaxation

A temperature probe attached to a microwave resonant cavity is interfaced to a microcomputer. The microcomputer allows temperature data to be taken very rapidly as a dielectric undergoes a phase change over a small temperature interval. This technique is shown to improve temperature measurements during dielectric relaxation studies in polar molecules near their phase transition temperatures.
The new German cinema: Music, history, and the matter of style

Acknowledgments Introduction: "Strategies of Remembrance" PART 1. HISTORICAL PREDECESSORS: MELODRAMA AND MODERNISM 1. Mourning, Melancholia, and "New German Melodrama" 2. Modernism's Aftershocks: Peer Raben's Film Music for Fassbinder PART 2. MUSIC AND THE MATERIALS OF HISTORY: ALEXANDER KLUGE 3. Kluge's Assault on History: Trauma, Testimony, and Difference in The Patriot 4. Undoing Act 5: History, Bodies, and Operatic Remains: Kluge's The Power of Emotion PART 3. QUEERING HISTORY THROUGH CAMP AND KITSCH 5. Restaging History with Fantasy: Body, Camp, and Sound in the Films of Treut, Ottinger, and von Praunheim 6. Introjecting Kitsch: Werner Schroeter, Music, and Alterity Coda: Working the Pieces Notes Index
Does voluntary medical male circumcision protect against sexually transmitted infections among men and women in real-world scale-up settings? Findings of a household survey in KwaZulu-Natal, South Africa

Introduction Male circumcision (MC) confers partial protection to men against HIV and, in research settings, some sexually transmitted infections (STIs). It is also associated with protection from some STIs among female partners. However, real-world data on changes in STI transmission associated with large-scale public African medical male circumcision (MMC) conducted for HIV prevention are lacking and would improve estimates of the health impact of MMC. Methods The HIV Incidence Provincial Surveillance System is a community-based surveillance platform for HIV prevalence, incidence and intervention coverage trends in KwaZulu-Natal province, South Africa. HIPPS collected cross-sectional self-reported data on circumcision status (from men), partner circumcision status for past three partners (from women) and demographic characteristics and behavioural risk factors; and tested participants for HIV, herpes simplex virus type 2 (HSV-2), syphilis, hepatitis B, Neisseriagonorrhoeae, Chlamydiatrachomatis, Trichomonasvaginalis and Mycoplasmagenitalium. Bivariable and multivariable analyses were performed on associations between own (men) or partner’s (women) circumcision status and each STI. Multivariable analyses adjusted for age, demographic characteristics and behavioural risk factors, and incorporated false discovery rate (FDR) correction. Results Among men, MMC had a protective association with HSV-2 (OR 0.66, 95% CI 0.50 to 0.86), hepatitis B (OR 0.53, 95% CI 0.30 to 0.95), HIV (OR 0.50, 95% CI 0.38 to 0.65) and M.genitalium (OR 0.53, 95% CI 0.32 to 0.88). Among women, partner circumcision had a protective association with HSV-2 (OR 0.71, 95% CI 0.53 to 0.95) and HIV (OR 0.66, 95% CI 0.49 to 0.90). Associations with HIV and HSV-2 remained significant for men and all women after FDR correction. Conclusion These real-world data, supporting protective associations between MMC conducted for HIV prevention and STIs in men and women, can help clarify the full impact of MMC and support a role in broader sexual health programming.
Start codon context controls translation initiation in the fungal kingdom

Eukaryotic protein synthesis initiates at a start codon defined by an AUG and its surrounding Kozak sequence context, but studies of S. cerevisiae suggest this context is of little importance in fungi. We tested this concept in two pathogenic Cryptococcus species by genome-wide mapping of translation and of mRNA 5’ and 3’ ends. We observed that upstream open reading frames (uORFs) are a major contributor to translation repression, that uORF use depends on the Kozak sequence context of its start codon, and that uORFs with strong contexts promote nonsense-mediated mRNA decay. Numerous Cryptococcus mRNAs encode predicted dual-localized proteins, including many aminoacyl-tRNA synthetases, in which a leaky AUG start codon is followed by a strong Kozak context in-frame AUG, separated by mitochondrial-targeting sequence. Further analysis shows that such dual-localization is also predicted to be common in Neurospora crassa. Kozak-controlled regulation is correlated with insertions in translational initiation factors in fidelity-determining regions that contact the initiator tRNA. Thus, start codon context is a signal that programs the expression and structures of proteins in fungi.
The Indonesian Version of Montreal Cognitive Assessment (MoCA-Ina): The Difference Scores Between Male Schizophrenia Prescribed by Risperidone and Adjunctive of Donepezil in Public Hospital of Dr Pirngadi Medan, Indonesia

BACKGROUND: Prescribing donepezil as an addition in reducing the cognitive dysfunctions among schizophrenia patients that have been given by antipsychotic (risperidone and olanzapine) is commonly used. Also, to determine the presence of the dysfunctions, an assessment is conducted by Montreal Cognitive Assessments based on Indonesian version (MoCA-Ina) to provide a more understandable test. AIM: To determine the score differences of MoCA-Ina between male patients of schizophrenia prescribed with only risperidone, and those with the addition of Donepezil within a certain interval of times. SETTINGS AND DESIGN: It is a pre-post-test experimental design with non-probability of consecutive sampling. METHODS: The study involved 48 of schizophrenia patients who have been prescribed fixed dose risperidone for 4 mg/day orally, and 24 people who were the intervention group were prescribed with the additional of 5 mg of donepezil per day started from the first until sixth week, followed by the increased dosages to 10 mg until twelfth week. These patients were recruited from the Public Hospital of Dr Pirngadi Medan, Indonesia, under the Department of Psychiatry. Then, the statistical data were analysed by Mann Whitney U, Friedman, and Wilcoxon, followed by analysing of SPSS version 21. RESULTS: The addition of five mg of Donepezil increased the MoCA-Ina score significantly compared to those who only prescribed with risperidone during all weeks of observation. CONCLUSION: Based on the results, the addition of donepezil increased the score level of the MoCA-Ina in the intervention group.
Effects of Aflatoxin on Kidney and Protective Effectiveness of Esterified Glucomannan in Ram

Bu calismada Merinos irki koclara agizdan verilen total aflatoksinin (AF) bobrek uzerine etkileri ile glukomannanin (EG) koruyucu etkinligi degerlendirildi. Calismada 1 yasinda 32 adet koc 4 esit gruba ayrildi. Beslemeye 92 gun devam edildi. Kontrol (K) grubuna ticari yem; AF grubuna ticari yem ile gunluk 250 µg AF; EG grubuna ticari yem ile gunluk 2 gr EG; AF+EG grubuna ise ticari yemle birlikte gunluk 250 µg AF ve 2 gr EG verildi. 92. gunun sonunda hayvanlar kesildikten sonra bobrekteki histolojik yapiyi gostermek icin ornekler alindi. AF grubunun bobrek tubullerinde dejenerasyon ve dokulmeler, bobrek damarlarinda ise yogun hiperemi gozlendi. Sonuc olarak; aflatoksikozun bobrek uzerindeki olumsuz etkilerinin yeme EG ilave edilerek iyilestirilebildigi ortaya konmustur.
Job satisfaction in critical care nurses

This descriptive study was designed to explore job satisfaction among critical care nurses using an established conceptual framework of job satisfaction entitled the Job Characteristics Model (Hackman & Oldham, 1980). The standardized measures of general job satisfaction and other job design variables were the Job Diagnostic Survey (Hackman & Oldham, 1980) and the Index of Job Satisfaction (Brayfield & Rothe, 1951). These were sent to a random sample of 300 employed critical care nurses in British Columbia. 127 usable questionnaires were returned and formed the basis for the results. The nurses found task significance and skill variety the strongest characteristics of motivating potential, task identity the lowest. The strongest relationships were seen between general job satisfaction and motivating potential of the job, meaningfulness of the work, and context satisfactions. There was also a significant relationship between general job satisfaction and length of nursing experience. iii Table of
Fluorescence picoseconde de complexes bio-moléculaires hors équilibre dans un écoulement microfluidique

Ce travail de these a demontre la possibilite de mesurer la relaxation d’un complexe biomoleculaire ainsi que son heterogeneite structurale, en associant la microfluidique et la fluorescence resolue en temps (FRT). Je presente de quelle facon la FRT permet d’obtenir une information sur la structure d’une molecule et comment on la mesure, notamment grâce a une camera a balayage de fente. J’introduis ensuite la microfluidique de gouttes, permettant de melanger deux reactifs en quelques millisecondes et de suivre la relaxation du complexe au cours de la propagation des micro-reacteurs. Puis, la mesure d’une cinetique avec un couple de molecules modele demontre la preuve de principe, faisant l’objet d’un article soumis. Enfin la mesure de FRT par comptage de photons uniques dans des gouttes uniques est decrite. Elle ouvre une perspective d’application pour le criblage a haut debit : un brevet a ete depose.
PELATIHAN APLIKASI MICROSOFT WORD 2013 PADA SMP H. A. JOHANSYAH. A BANJARMASIN

Microsoft Word is one of the software / word processing program created by Microsoft and included in bandle Microsoft Office. Microsoft Word into a word processing program that is reliable and most widely used by computer users. So with the Microsoft Word so provide enormous benefits to the world of technology is constantly evolving, in terms of word processors used for productive activities, educational and various other things that require a powerful word processing application.
The Abnormal Mobile Malware Analysis Based on Behavior Categorization

With the explosive growth of mobile malware in mobile internet, many polymorphic and metamorphic mobile malware appears and causes difficulty of detection. A mobile malware network behavior data mining method based on behavior categorization is proposed to detect the behavior of new or metamorphic mobile malware. The network behavior is divided into different categories after analyzing the behavior character of mobile malware and those different behavior data of known malware and normal action are used to train the Naïve Bayesian classifier respectively. Those Naïve Bayesian classifiers are used to detect the mobile malware network behavior. The experiment result shows that Behavior Categorization based Naïve Bayesian Classifier (BCNBC) can improve the detection accuracy and it can meet the requirement of real time process in mobile internet.
AN IMAGE CRAWLER FOR CONTENT BASED IMAGE RETRIEVAL SYSTEM

Images from the minute it was invented, has had an immense impact on the world we live in. The extract ing the required images from the World Wide Web (WWW) is very difficult because web contains a huge number of images. To solve this problem we need a system that can retrieve the required images needed by the user. Image Crawler is a web based tool that colle cts and indexes group of web images available on the internet. This tool collect s the keyword or phrase from the user to retrieve tfrom the web. Then these collected keyword is applied to the different general search tools like Google, Yahoo, Bind etc, . The collected web page information is stored in the temporary file till 200KB file size from the server. Then this file cont ent will be scanned and extract the image URL’s and it is compared the URL which is pre sent in the database to avoid the duplicate downloa ds. The extracted URL’s images are downloaded and finally stores unique im age and corresponding metadata like filename, url, size etc. in the database. In this paper we present the designing of an Image cra wler tool. We build a search tool which is flexible , general-purpose image search framework and explore a directed result aggregating and removing of duplicates to achieve top results compared to other existing search tools. Finally this resulted images are used in the Content Based Image Retrieval (CBIR) system for extracting the relevant images need by the client using the content of the images rather than the text based information.
Spinal microglia contribute to cancer-induced pain through system xC−-mediated glutamate release

Abstract Introduction: Microglial cells, the resident macrophages of the central nervous system, are a key contributor to the generation and maintenance of cancer-induced pain (CIP). In healthy organisms, activated microglia promote recovery through the release of trophic and anti-inflammatory factors to clear toxins and pathogens and support neuronal survival. Chronically activated microglia, however, release toxic substances, including excess glutamate, causing cytotoxicity. Accordingly, rising attention is given to microglia for their role in abnormal physiology and in mediating neurotoxicity. Objectives: To examine the nociceptive relationship between peripherally-released glutamate and microglial xCT. Methods: A validated murine model of 4T1 carcinoma cell–induced nociception was used to assess the effect of peripheral tumour on spinal microglial activation and xCT expression. Coculture systems were then used to investigate the direct effect of glutamate released by wildtype and xCT knockdown MDA-MB-231 carcinoma cells on microglial activation, functional system xC− activity, and protein levels of interferon regulatory factor 8 (IRF8), a transcription factor implicated in microglia-mediated nociception. Results: Blockade of system xC− with sulfasalazine (SSZ) in vivo attenuated nociception in a 4T1 murine model of CIP and attenuates tumour-induced microglial activation in the dorsal horn of the spinal cord. Furthermore, knockdown of xCT in MDA-MB-231 cells mitigated tumour cell–induced microglial activation and functional system xC− activity in vitro. Conclusions: These data collectively demonstrate that the system xCT antiporter is functionally implicated in CIP and may be particularly relevant to pain progression through microglia. Upregulated xCT in chronically activated spinal microglia may be one pathway to central glutamate cytotoxicity. Microglial xCT may therefore be a valuable target for mitigating CIP.