Miracle-dz/UniFAR-FTUs huggingface dataset:
Recent advance in nanotechnology has led to a major breakthrough in the fabrication and performance of nano-hybrid superconducting devices based on semiconducting nanostructures

We report on the superconducting and structural characteristics of Pb-based alloy (Pb0.9In0.1, Pb0.8In0.2 and Pb0.85Bi0.15) thin films, depending on the film deposition rate. The maximum critical magnetic field strength of Pb0.85Bi0. 15 is almost six times larger than that of Pb0.9In0. 1, and more rapid growth of the film enhances the critical magnetic field strength even for the same alloy material. Scanning electron microscopy inspection indicates that lower deposition rate condition is vulnerable to the formation of void structure in the film. Topographic images using atomic force microscopy are useful to optimize the deposition condition for the growth of smooth superconducting film. Our work can be utilized for future studies on hybrid superconducting devices using low-dimensional nanostructures.
The e¡ectof increased branched-chainaminoacid transaminase activity inyeaston theproductionof higheralcohols and on the £avour pro¢lesofwineand distillates

activity inyeaston theproductionof higheralcohols and on the £avour pro¢lesofwineand distillates Mariska Lilly, Florian F. Bauer, Gustav Styger, Marius G. Lambrechts & Isak S. Pretorius Institute for Wine Biotechnology, Stellenbosch University, Victoria Street, Stellenbosch, South Africa; Distell, Stellenbosch, South Africa; and The Australian Wine Research Institute, Waite Road, Urrbrae, Adelaide, SA, Australia
May 09, 2020 Spatiotemporal SNP analysis reveals pronounced biocomplexity at the northern range margin of Atlantic

Nielsen, E. (2013). SNP analysis biocomplexity at Abstract Accurate prediction of species distribution shifts in the face of climate change requires a sound understanding of population diversity and local adaptations. Previous modeling has suggested that global warming will lead to increased abundance of Atlantic cod ( Gadus morhua ) in the ocean around Greenland, but the dynamics of earlier abundance ﬂuctuations are not well understood. We applied a retrospective spatiotemporal population genomics approach to examine the temporal stability of cod population structure in this region and to search for signatures of divergent selection over a 78-year period spanning major demographic changes. Analyzing > 900 gene-associated single nucleotide polymorphisms in 847 individuals, we identiﬁed four genetically distinct groups that exhibited varying spatial distributions with considerable overlap and mixture. The genetic composition had remained stable over decades at some spawning grounds, whereas complete population replacement was evident at others. Observations of elevated differentiation in certain genomic regions are consistent with adaptive divergence between the groups, indicating that they may respond differently to environmental variation. Signiﬁcantly increased temporal changes at a subset of loci also suggest that adaptation may be ongoing. These ﬁndings illustrate the power of spatiotemporal population genomics for revealing biocomplexity in both space and time and for informing future ﬁsheries management and conservation efforts.
[kW] 376; 180 Rated torque T n [Nm]; rated speed N n [rpm] type

 Abstract -- IPM machines are characterized by high saturation and cross-coupling effect. In this paper a procedure is proposed to identify an IPM machine model able to taking into account in a simple and accurate manner both the cited effects. The model is based on functions that express the direct links  sdq (  i sdq ), and the inverse link  i sdq (  sdq ), where  i sdq and  sdq are the stator current and stator flux linkage space vectors respectively. The paper shows that such a model is helpful for the analysis
Associat ion of Toxicity of Sorafenib and Sunit inib for Human Kerat inocytes with Inhibit ion of Signal Transduct ion and Act ivator

Hand–foot skin reaction is a most common multi-kinase inhibitor-related adverse event. This study aimed to examine whether the toxicity of sorafenib and sunitinib for human keratinocytes was associated with inhibiting signal transduction and activator of transcription 3 (STAT3). We studied whether STAT3 activity affects sorafeniband sunitinib-induced cell growth inhibition in HaCaT cells by WST-8 assay. Stattic enhanced the cell-growth inhibitory and apoptotic effects of sorafenib and sunitinib. HaCaT cells transfected with constitutively-active STAT3 (STAT3C) were resistant to the sorafeniband sunitinib-induced cell growth inhibition. STAT3 activity decreased after short-term treatment with sorafenib and sunitinib in a dose-dependent manner and recovered after long-term treatment with sorafenib and sunitinib at low doses. Moreover, the expression of survivin and bcl-2 decreased after treatment with sorafenib and sunitinib was concomitant with variations in STAT3 activity. Sorafenib-induced STAT3 inhibition was mediated by regulation via MAPK pathways in HaCaT cells, while sunitinib-induced STAT3 inhibition was not. Thus, STAT3 activation mediating apoptosis suppressors may be a key factor in sorafenib and sunitinib-induced keratinocyte cytotoxicity. Citation: Yamamoto K, Mizumoto A, Nishimura K, Uda A, Mukai A, et al. (2014) Association of Toxicity of Sorafenib and Sunitinib for Human Keratinocytes with Inhibition of Signal Transduction and Activator of Transcription 3 (STAT3). PLoS ONE 9(7): e102110. doi:10.1371/journal.pone. 0102110 Editor: Andrzej T. Slominski, University of Tennessee, United States of America Received February 12, 2014; Accepted June 15, 2014; Published July 11, 2014 Copyright: 2014 Yamamoto et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This work was supported by a research grant from The Nakatomi Foundation and JSPS KAKENHI (Grant Number 24790156). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist. * Email: yamakz@med.kobe-u.ac. jp
Hepatoprotective effect of β-myrcene pretreatment against acetaminophen-induced liver injury

Objective: In the present study, the hepatoprotective effects of β-myrcene (MYR) on acetaminophen-induced hepatotoxicity were investigated. Materials and Methods: A total of 40 Balb/c mice were randomly divided into five groups as follows: 1) Normal control group which received only carboxymethylcellulose (CMC), the vehicle used to dissolve acetaminophen (N-acetyl-p-aminophenol, APAP, paracetamol) and MYR; 2) APAP group which received a single dose of acetaminophen (250 mg/kg) orally on day 7; 3) Silymarin group which received 200 mg/kg/day of silymarin; and 4 and 5) pretreatment groups in which, mice were treated with 100 or 200 mg/kg/day of MYR. Liver and blood samples were collected to analyze serum aminotransferases, inflammatory response, oxidative stress markers, and histopathological insults. Results: Our results showed that MYR pretreatment attenuated liver damage and restored liver cells function and integrity as it decreased the leakage of serum aminotransferases (alanine and aspartate aminotransferases (ALT and AST, respectively)) into the blood (p<0.01). MYR treatment also reduced levels of myeloperoxidase (MPO) activity and nitric oxide (NO) (p<0.001). In addition, MYR pretreatment demonstrated significant antioxidant activity by decreasing malondialdehyde (MDA), reactive oxygen species (ROS), and reduced glutathione (GSH) levels (p<0.001). Furthermore, it restored the hepatic level of superoxide dismutase (SOD), catalase (CAT), and oxidized glutathione (GSSG) (p<0.001). Conclusion: For the first time, our results showed that MYR treatment significantly improved liver function by reducing oxidative stress and the inflammatory response induced by APAP.
In-hospital outcomes of patients with spontaneous supratentorial intracerebral hemorrhage

Spontaneous intracerebral hemorrhage (ICH) in the brain parenchyma accounts for 16.1% of all stroke types in Taiwan. It is responsible for high morbidity and mortality in some underlying causes. The objective of this study is to discover the predicting factors focusing on in-hospital outcomes of patients with spontaneous supratentorial ICH. Between June 2014 and October 2018, there were a total of 159 patients with spontaneous supratentorial ICH ranging from 27 to 91 years old in our institution. Twenty-three patients died during hospitalization, whereas 59 patients had an extended length of stay of >30 days. The outcomes were measured by inpatient death, length of stay, and activity of daily living (ADL). Both univariate and multivariate binary logistic regression, as well as multivariate linear regression, were used for statistical analysis. Multivariate binary linear regression analysis showed the larger hematoma in initial computed tomography scan of >30 cm3 (odds ratio [OR] = 2.505, P = .013) and concurrent in-hospital infection (OR = 4.173, P = .037) were both statistically related to higher mortality. On the other hand, in-hospital infection (≥17.41 days, P = .000) and surgery (≥11.23 days, P = .001) were correlated with a longer length of stay. Lastly, drastically poor change of ADL (ΔADL <–30) was associated with larger initial ICH (>30 cc, OR = 2.915, P = .049), in-hospital concurrent infection (OR = 4.695, P = .01), and not receiving a rehabilitation training program (OR = 3.473, P = .04). The results of this study suggest that age, prothrombin, initial Glasgow Coma Scale, computed tomography image, location of the lesion, and surgery could predict the mortality and morbidity of the spontaneous ICH, which cannot be reversed at the time of occurrence. However, effective control of international normalized ratio level, careful prevention against infection, and the aid of rehabilitation programs might be important factors toward a decrease of inpatient mortality rate, the length of stay, and ADL recovery.
Co-Production of Knowledge and Dialogue: A Reflective Analysis of the Space Between Academic and Lay Co-Researchers in the Early Stages of the Research Process

: Co-production of knowledge, where academic and lay researchers work as partners, is a central characteristic of participatory action research. It requires the participants to engage in a transformative dialogue. But how can co-production of knowledge function in the care home setting? We addressed this question in a specific interaction between academic and lay researchers in an action research project sited in a nursing home in Germany. Drawing on Paulo FREIRE and Mikhail BAKHTIN, we developed seven dialogue criteria and applied them as sensitizing concepts. In order to further a critical analysis, in our data analysis we combined three methodical approaches: 1. analytical autoethnography, 2. sequential analysis in the tradition of objective hermeneutics, and 3. reflection with critical friends. This innovative triangulation allowed for rich and complex interpretations. We found that all seven dialogue criteria are important to co-production of knowledge and should direct the process between academic and lay researchers.
Distributed source localization of epileptiform discharges in juvenile myoclonic epilepsy: Standardized low-resolution brain electromagnetic tomography (sLORETA) Study

Juvenile myoclonic epilepsy (JME) is a common generalized epilepsy syndrome considered the prototype of idiopathic generalized epilepsy. To date, generalized and focal seizures have been the fundamental concepts for classifying seizure types. In several studies, focal features of JME have been reported predominantly in the frontal lobe. However, results in previous studies are inconsistent. Therefore, we investigated the origin of epileptiform discharges in JME. We performed electroencephalography source localization using a distributed model with standardized low-resolution brain electromagnetic tomography. In 20 patients with JME, standardized low-resolution brain electromagnetic tomography images corresponding to the midpoint of the ascending phase and the negative peak of epileptiform discharges were obtained from a total of 362 electroencephalography epochs (181 epochs at each timepoint). At the ascending phase, the maximal current source density was located in the frontal lobe (58.6%), followed by the parietal (26.5%) and occipital lobes (8.8%). At the negative peak, the maximal current source density was located in the frontal lobe (69.1%), followed by the parietal (11.6%) and occipital lobes (9.4%). In the ascending phase, 41.4% of discharges were located outside the frontal lobe, and 30.9% were in the negative peak. Frontal predominance of epileptiform discharges was observed; however, source localization extending to various cortical regions also was identified. This widespread pattern was more prominent in the ascending phase (P = .038). The study results showed that JME includes widespread cortical regions over the frontal lobe. The current concept of generalized epilepsy and pathophysiology in JME needs further validation.
Characterization of the ﬁrst two viruses described from wild populations of hammer orchids ( Drakaea spp.) in Australia

Sequences representing the genomes of two distinct virus isolates infecting wild plants of two members of the genus Drakaea (hammer orchids) in Western Australia are described. The virus isolated from Drakaea livida has a bipartite genome of 4490 nt (RNA1) and 2905 nt (RNA2) that shares closest sequence and structural similarity to members of the genus Pecluvirus, family Virgaviridae , described from legumes in the Indian subcontinent and West Africa. How-ever, it differs from pecluviruses by lacking a P39 protein on RNA2 and having a cysteine-rich protein gene located 3 0 of the triple gene block protein genes. It is the ﬁrst peclu-like virus to be described from Australia. The name Drakaea virus A is proposed (DVA; proposed member of the family Virgaviridae , genus unassigned). The second virus isolate was identiﬁed from Drakaea elastica , a species classed as endangered under conservation legislation. The genome sequence of this virus shares closest identity with isolates of Donkey orchid symptomless virus (DOSV; proposed member of the order Tymovirales , family and genus unassigned), a species described previously from wild Caladenia and Diuris orchids in the same region. These viruses are the ﬁrst to be isolated from wild Drakaea populations and are proposed to have an ancient association with their orchid hosts.
Odometry-prefered scan matching method

In this paper, we address the problem of estimating rigid body transformations in two-dimensional space. A new probabilistic weight function is proposed to find a solution closes to odometry information more preferably. The weight function is motivated by hypothesis that a solution of a scan matching problem which prefers odometry information may show better performance in terms of accuracy and convergence. Through the test with three real data sets, our hypothesis was confirmed.
Yet1p and Yet3p, the Yeast Homologs of BAP29 and BAP31, Interact with the ER Translocation Apparatus and are Required for Inositol Prototrophy

The mammalian B-cell receptor associated proteins of 29 and 31 kilodaltons (BAP29 and BAP31) are conserved integral membrane proteins that have reported roles in endoplasmic reticulum (ER) quality control, ER export of secretory cargo and programmed cell death. In this study we investigated the yeast homologs of BAP29 and BAP31, known as Yet1p and Yet3p, to gain insight on cellular function. We found that Yet1p forms a complex with Yet3p (Yet complex) and that complex assembly was important for subunit stability and proper ER localization. The Yet complex was not efficiently packaged into ER-derived COPII vesicles and therefore does not appear to act as an ER export receptor. Instead, a fraction of the Yet complex was detected in association with the ER translocation apparatus (Sec complex). Specific mutations in the Sec complex or the Yet complex influenced these interactions. Moreover, associations between the Yet complex and the Sec complex were increased by ER stress and diminished when protein translocation substrates were depleted. Surprisingly, yet1Δ and yet3Δ mutant strains displayed inositol starvationrelated growth defects. In accord with the biochemical data, these growth defects were exacerbated by combination of certain mutations in the Sec complex with yet1Δ or yet3Δ mutations. We propose a model for the Yet-Sec complex interaction that places Yet1p and Yet3p at the translocation pore to manage biogenesis of specific transmembrane secretory proteins.
Experimental investigation of fan for personal protection equipment – influence of number of blades

The aim of research is development of new generation of powered air purifying respirators designed to filtrate contaminants in the form of gases, vapours and particles. These high performance units guarantee sufficient protection of the wearer even in heavy industrial environments, the chemical industry, laboratories and the pharmaceutical industry [4]. To help people while breathing through filter, a fan is used to propel air flowing in personal respiratory protection systems and units. Because, the reliability and efficiency are crucial for operation of these systems, our work is focused on improvement and optimization of a centrifugal fan used.
Inﬂammation-induced caveolin-1 and BMPRII depletion promotes endothelial dysfunction and TGF- (cid:2) -driven pulmonary vascular remodeling

Inﬂammation-induced caveolin-1 and BMPRII depletion promotes endothelial dysfunction and TGF- (cid:2) driven pulmonary vascular remodeling. Am Physiol Lung Cell Mol Physiol cell (EC) activation and vascular injury are hallmark features of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Caveolin-1 (Cav-1) is highly expressed in pulmonary microvascular ECs and plays a key role in maintaining vascular homeostasis. The aim of this study was to determine if the lung inﬂammatory response to Escherichia coli lipopolysaccharide (LPS) promotes priming of ECs via Cav-1 depletion and if this contributes to the onset of pulmonary vascular remodeling. To test the hypothesis that depletion of Cav-1 primes ECs to respond to proﬁbrotic signals, C57BL6 wild-type (WT) mice ( Tie2.Cre (cid:3) ;Cav1 ﬂ/ﬂ ) were exposed to nebulized LPS (10 mg; 1 h daily for 4 days) and compared with EC-speciﬁc Cav1 (cid:3) / (cid:3) ( Tie2.Cre (cid:4) ;Cav1 ﬂ/ﬂ ). After 96 h of LPS exposure, total lung Cav-1 and bone morphogenetic protein receptor type II (BMPRII) expression were reduced in WT mice. Moreover, plasma albumin leakage, inﬁltration of immune cells, and levels of IL-6/IL-6R and transforming growth factor- (cid:2) (TGF- (cid:2) ) were elevated in both LPS-treated WT and EC-Cav1 (cid:3) / (cid:3) mice. Finally, EC-Cav1 (cid:3) / (cid:3) mice exhibited a modest increase in microvascular thickness basally and even more so on exposure to LPS (96 h). EC-Cav1 (cid:3) / (cid:3) mice and LPS-treated WT mice exhibited reduced BMPRII expression and endothelial nitric oxide synthase uncoupling, which along with increased TGF- (cid:2) promoted TGF (cid:2) RI-dependent SMAD-2/3 phosphorylation. Finally, human lung sections from patients with ARDS displayed reduced EC Cav-1 expression, elevated TGF- (cid:2) levels, and severe pulmonary vascular remodeling. Thus EC Cav-1 depletion, oxidative stress-mediated reduction in BMPRII expression, and enhanced TGF- (cid:2) -driven SMAD-2/3 signaling promote pulmonary vascular remodeling in inﬂamed lungs.
Investigating Scheduling and Load Balancing Characteristics of Task-based Programming Models for Hybrid HPC Applications

In hybrid HPC applications, load imbalances that can be caused by either hardware or software, may have a significant performance impact. Software-induced load imbalances can be caused by the operating system or by applications with changing load distributions such as Adaptive Mesh Refinement algorithms. Unpredictable latencies in complex memory hierarchies or clock frequency boosts are causes for hardware-induced load imbalances. Using a task-based programming paradigm is an approach to dynamically achieve dynamic load balancing. There are established task-based frameworks for shared memory environments, but frameworks for distributed memory environments face the additional challenge of balancing the load across process boundaries. The goal of this thesis is to analyze and compare different scheduling and load balancing mechanisms used in task-based frameworks. Three frameworks were considered: Charm++, StarPU and Chameleon. Charm++ is a message-driven framework that uses migratable objects. StarPU provides taskbased programming capabilities with an a-priori cross-rank load balancing mechanism. Chameleon is a framework designed for fine-granular, reactive load balancing using task migration. Using two benchmarks, empirical experiments were performed to test the frameworks scalability, their reaction to hardwareand software-induced load imbalances and the effects of task-granularity on the performance. It was found that Chameleon offers the most fine-granular load balancing capability, but also introduces overhead with a dedicated communication thread. Chameleon was superior to the other frameworks in experiments with hardware-induced load imbalances and achieved a speedup of up to 1.15 compared to the baseline implementation. Charm++ was found to be the most versatile framework with a range of load balancing strategies. It performed best in experiments with software-induced load imbalances in an iterative application where it achieved a speedup of up to 1.36 compared to the baseline implementation. StarPU was unable to provide the desired load balancing properties.
Discussion Papers in Economics Stable and Efficient Networks with Farsighted Players: the Largest Consistent Set

In this paper we study strategic formation of bilateral networks with farsighted players in the classic framework of Jackson and Wolinsky (1996). We use the largest consistent set (LCS)(Chwe (1994)) as the solution concept for stability. We show that there exists a value function such that for every component balanced and anonymous allocation rule, the corresponding LCS does not contain any strongly eﬃcient network. Using Pareto eﬃciency, a weaker concept of eﬃciency, we get a more positive result. However, then also, at least one environment of networks (with a component balanced and anonymous allocation rule) exists for which the largest consistent set does not contain any Pareto eﬃcient network. These conﬁrm that the well-known problem of the incompatibility between the set of stable networks and the set of eﬃcient networks persists even in the environment with farsighted players. Next we study some possibilities of resolving this incompatibility.