Miracle-dz/UniFAR-FTUs huggingface dataset:
DialogueScore: Evaluating Responses in Task-Oriented Dialogue Anonymous

Task-Oriented Dialogue systems have been 001 widely deployed in real-world applications in 002 the last few years. Yet, evaluations of task-003 oriented dialogue systems are relatively lim-004 ited. The informative and success score only 005 consider the key entities in the generated re-006 sponses to judge whether the user’s goal is 007 achieved. On the other hand, the ﬂuency met-008 ric (BLEU score) cannot measure the qual-009 ity of the short responses properly since the 010 golden responses could be diversiﬁed. To bet-011 ter explore the behavior and evaluate the gener-012 ation ability of task-oriented dialogue systems, 013 we explore the relation between user utter-014 ances and system responses and their follow-015 up utterances. Therefore, we design a scorer 016 named DialogueScore based on the natural 017 language inference task and synthesize neg-018 ative data to train the scorer. Via perfor-019 mances of DialogueScore , we observe that 020 the dialogue system fails to generate high-021 quality responses compared with the reference 022 responses. Therefore, our proposed scorer 023 could provide a new perspective for future dia-024 logue system evaluation and construction. 025
Modeling human dynamics with adaptive interest

Increasing recent empirical evidence indicates the extensive existence of heavy tails in the inter-event time distributions of various human behaviors. Based on the queuing theory, the Barabási model and its variations suggest the highest-priority-first protocol to be a potential origin of those heavy tails. However, some human activity patterns, also displaying heavy-tailed temporal statistics, could not be explained by a task-based mechanism. In this paper, different from the mainstream, we propose an interest-based model. Both the simulation and analysis indicate a power-law inter-event time distribution with exponent −1, which is in accordance with some empirical observations in human-initiated systems.
Reliability of gradient-based segmentation for measuring metabolic parameters influenced by uptake time on 18F-PSMA-1007 PET/CT for prostate cancer

Purpose To determine an optimal setting for functional contouring and quantification of prostate cancer lesions with minimal variation by evaluating metabolic parameters on 18F-PSMA-1007 PET/CT measured by threshold-based and gradient-based methods under the influence of varying uptake time. Methods and materials Dual time point PET/CT was chosen to mimic varying uptake time in clinical setting. Positive lesions of patients who presented with newly diagnosed disease or biochemical recurrence after total prostatectomy were reviewed retrospectively. Gradient-based and threshold-based tools at 40%, 50% and 60% of lesion SUVmax (MIM 6.9) were used to create contours on PET. Contouring was considered completed if the target lesion, with its hottest voxel, was delineated from background tissues and nearby lesions under criteria specific to their operations. The changes in functional tumour volume (FTV) and metabolic tumour burden (MTB, defined as the product of SUVmean and FTV) were analysed. Lesion uptake patterns (increase/decrease/stable) were determined by the percentage change in tumour SUVmax at ±10% limit. Results A total of 275 lesions (135 intra-prostatic lesions, 65 lymph nodes, 45 bone lesions and 30 soft tissue lesions in pelvic region) in 68 patients were included. Mean uptake time of early and delayed imaging were 94 and 144 minutes respectively. Threshold-based method using 40% to 60% delineated only 85 (31%), 110 (40%) and 137 (50%) of lesions which all were contoured by gradient-based method. Although the overall percentage change using threshold at 50% was the smallest among other threshold levels in FTV measurement, it was still larger than gradient-based method (median: 50%=-7.6% vs gradient=0%). The overall percentage increase in MTB of gradient-based method (median: 6.3%) was compatible with the increase in tumour SUVmax. Only a small proportion of intra-prostatic lesions (<2%), LN (<4%), bone lesions (0%) and soft tissue lesions (<4%) demonstrated decrease uptake patterns. Conclusions With a high completion rate, gradient-based method is reliable for prostate cancer lesion contouring on 18F-PSMA-1007 PET/CT. Under the influence of varying uptake time, it has smaller variation than threshold-based method for measuring volumetric parameters. Therefore, gradient-based method is recommended for tumour delineation and quantification on 18F-PSMA-1007 PET/CT.
Investigation on distribution of electro-thermal coupling fields influenced by HVDC bushing insulation properties

Bushing is an indispensable component in high voltage direct current (HVDC) transmission project. As the main insulating material possesses poor thermal conductivity and negative temperature coefficient (NTC) electrical resistivity, HVDC bushing suffers from the distortion of electro-thermal-coupled fields. Therefore, it is urgent to reveal the influence of electrical resistivity-temperature characteristic and thermal conductivity on the DC electric field distribution within bushing insulation, guiding the design and application advanced insulating materials. Here, the simulation of temperature and DC electric field distribution within a 400 kV bushing are carried out. The results show that the optimization of NTC effect and thermal conductivity of an insulating material is able to obtain a more uniform electric field distribution through homogenizing the electric resistivity distribution within bushing insulation. The activation energy of the insulating material has a similar variation trend with the maximum electric field within bushing insulation, which has a potential to represent the temperature dependence of electrical resistivity of insulating materials. It also shows that the reduction of DC electric field by increasing the thermal conductivity has a saturation feature. As a result, the suppression of the NTC effect should be considered together to obtain a smaller electric field within HVDC bushing. The research study provides a new idea to regulate the DC electric field distribution, which is beneficial to the design of advanced insulating materials.
The impact of environmental subsidy on the performance of corporate environmental responsibility: Evidence from China

Corporate environmental responsibility (CER) has become a critical factor for measuring the competitiveness of firms in China, and environmental subsidies may be a catalyst for promoting firms’ CER. This study uses data from Chinese A-share listed firms during 2010–2020. Using the instrumental variable two-stage least squares (IV-2SLS) method, we found that environmental subsidies significantly improve corporate environmental performance but have no significant impact on the disclosure and governance of pollution emissions. We find that environmental subsidies are better for chemical and energy firms with high pollution levels, provide incentives for non-state-owned firms to improve CER and that their effect in western and eastern China is better than that in the central region. We also found that corporate social responsibility plays a moderating role in environmental subsidies that affect CER. Finally, this study finds that environmental subsidies may crowd out corporate investments to improve environmental performance. Based on the above results, we provide the corresponding policy suggestions.
Safety and efficacy of fecal microbiota transplantation for autoimmune diseases and autoinflammatory diseases: A systematic review and meta-analysis

Objective To evaluate the safety and efficacy of fecal microbiota transplantation for autoimmune diseases and autoinflammatory diseases. Methods Relevant literature was retrieved from the PubMed database, Embase database, Cochrane Library database, etc. The search period is from the establishment of the database to January 2022. The outcomes include clinical symptoms, improvement in biochemistry, improvement in intestinal microbiota, improvement in the immune system, and adverse events. Literature screening and data extraction were independently carried out by two researchers according to the inclusion and exclusion criteria, and RevMan 5.3 software was used for statistics and analysis. Results Overall, a total of 14 randomized controlled trials (RCTs) involving six types of autoimmune diseases were included. The results showed the following. 1) Type 1 diabetes mellitus (T1DM): compared with the autologous fecal microbiota transplantation (FMT) group (control group), the fasting plasma C peptide in the allogenic FMT group at 12 months was lower. 2) Systemic sclerosis: at week 4, compared with one of two placebo controls, three patients in the experimental group reported a major improvement in fecal incontinence. 3) Ulcerative colitis, pediatric ulcerative colitis, and Crohn’s disease: FMT may increase clinical remission, clinical response, and endoscopic remission for patients with ulcerative colitis and increase clinical remission for patients with Crohn’s disease. 4) Psoriatic arthritis: there was no difference in the ratio of ACR20 between the two groups. Conclusion Based on current evidence, the application of FMT in the treatment of autoimmune diseases is effective and relatively safe, and it is expected to be used as a method to induce remission of active autoimmune diseases. Systematic review registration https://www.crd. york.ac. uk/prospero/display_record. php? ID=CRD42021235055, identifier CRD42021235055.
Association mapping and candidate genes for physiological non-destructive traits: Chlorophyll content, canopy temperature, and specific leaf area under normal and saline conditions in wheat

Wheat plants experience substantial physiological adaptation when exposed to salt stress. Identifying such physiological mechanisms and their genetic control is especially important to improve its salt tolerance. In this study, leaf chlorophyll content (CC), leaf canopy temperature (CT), and specific leaf area (SLA) were scored in a set of 153 (103 having the best genotypic data were used for GWAS analysis) highly diverse wheat genotypes under control and salt stress. On average, CC and SLA decreased under salt stress, while the CT average was higher under salt stress compared to the control. CT was negatively and significantly correlated with CC under both conditions, while no correlation was found between SLA and CC and CT together. High genetic variation and broad-sense-heritability estimates were found among genotypes for all traits. The genome wide association study revealed important QTLs for CC under both conditions (10) and SLA under salt stress (four). These QTLs were located on chromosomes 1B, 2B, 2D, 3A, 3B, 5A, 5B, and 7B. All QTLs detected in this study had major effects with R2 extending from 20.20% to 30.90%. The analysis of gene annotation revealed three important candidate genes (TraesCS5A02G355900, TraesCS1B02G479100, and TraesCS2D02G509500). These genes are found to be involved in the response to salt stress in wheat with high expression levels under salt stress compared to control based on mining in data bases.
Characterization of B-box family genes and their expression profiles under abiotic stresses in the Melilotus albus

B-box (BBX) proteins are one of the zinc-finger transcription factor that plays a critical role in plant development, growth, and multiple stress responses. Although BBX genes have been reported in many model organisms, no comprehensive study has yet been conducted on the BBX genes in Melilotus albus, and the biological functions of this family remain unknown. In this study, a total of 20 BBX (MaBBX) genes were identified in M. albus and were phylogenetically divided into five clades. BBX members within the same clade showed similar conserved domain, suggesting similarity of potential biological function. Analysis of MaBBX conserved motifs showed that every subfamily contained two common motifs. Distribution mapping shows that BBX proteins are nonrandomly localized in eight chromosomes. The synteny showed that most homologous gene pairs of the MaBBX gene family were amplified by segmental replication, which meant segmental replication was the main way for the MaBBX gene family to evolve. Additionally, the cis-element analysis predicted light-responsive, various hormone and stress-related elements in the promoter regions of MaBBXs. Furthermore, the expression levels of all 20 MaBBX genes were detected by qRT-PCR under salt, cold, and dark stresses in M. albus. Moreover, it was observed that 16 genes had higher expression levels after 3 h of salt treatment, 10 genes were significantly upregulated after 3 h of cold treatment, and all genes were up regulated after 3 h of dark treatment, and then appeared to decline. In addition, it was also noticed that MaBBX13 may be an important candidate for improving tolerance to abiotic stress. The prediction of protein tertiary structure showed that the tertiary structures of members of the same subfamily of MaBBX proteins were highly similar. The hypothesis exhibited that most of the MaBBX proteins were predicted to be localized to the nucleus and cytoplasm and was validated by transient expression assays of MaBBX15 in tobacco leaf epidermal cells. This study provides useful information for further investigating and researching the regulatory mechanisms of BBX family genes in response to abiotic stresses in M. albus.
The impact of different age-friendly smart home interface styles on the interaction behavior of elderly users

Smart homes create a beneficial environment for the lives of elderly people and enhance the quality of their home lives. This study aims to explore the design of age-friendly interfaces that can meet the emotional needs of self-care elderly people from the perspective of functional realization of the operating interface. Sixteen elderly users aged fifty-five and above were selected as subjects with healthy eyes and no excessive drooping eyelids to obscure them. Four representative age-friendly applications with different interface designs were selected from the Android application market as the stimulus material for the experiment, and a total of fifteen pages were browsed independently. During the experiment, the ErgoLAB human-computer environment synchronization cloud platform was used to monitor and record the subjects' multidimensional physiological indicators of eye movements, skin electricity, and heart rate variability when using different styles of mobile application interfaces. Combined with the post-experimental PAD emotion scale data, the preferences of emotional interface design elements of the self-care elderly were analyzed to guide the subsequent design practice. The results show that: on the layout characteristics of the home page, a simple and intuitive multi-column layout or card layout combined with a bottom navigation bar type main navigation is used; on the choice of the main color, a single color with low saturation is used as the main color, with high saturation color accents to play a role in highlighting key information; on the information density of the home page, a moderate proportion of graphics and text is adopted, with low information density; on the arrangement of the page content, they try to give priority to information content with high user relevance.
Sox13 is a novel flow-sensitive transcription factor that prevents inflammation by repressing chemokine expression in endothelial cells

Atherosclerosis is a chronic inflammatory disease and occurs preferentially in arterial regions exposed to disturbed blood flow (d-flow) while the stable flow (s-flow) regions are spared. D-flow induces endothelial inflammation and atherosclerosis by regulating endothelial gene expression partly through the flow-sensitive transcription factors (FSTFs). Most FSTFs, including the well-known Kruppel-like factors KLF2 and KLF4, have been identified from in vitro studies using cultured endothelial cells (ECs). Since many flow-sensitive genes and pathways are lost or dysregulated in ECs during culture, we hypothesized that many important FSTFs in ECs in vivo have not been identified. We tested the hypothesis by analyzing our recent gene array and single-cell RNA sequencing (scRNAseq) and chromatin accessibility sequencing (scATACseq) datasets generated using the mouse partial carotid ligation model. From the analyses, we identified 30 FSTFs, including the expected KLF2/4 and novel FSTFs. They were further validated in mouse arteries in vivo and cultured human aortic ECs (HAECs). These results revealed 8 FSTFs, SOX4, SOX13, SIX2, ZBTB46, CEBPβ, NFIL3, KLF2, and KLF4, that are conserved in mice and humans in vivo and in vitro. We selected SOX13 for further studies because of its robust flow-sensitive regulation, preferential expression in ECs, and unknown flow-dependent function. We found that siRNA-mediated knockdown of SOX13 increased endothelial inflammatory responses even under the unidirectional laminar shear stress (ULS, mimicking s-flow) condition. To understand the underlying mechanisms, we conducted an RNAseq study in HAECs treated with SOX13 siRNA under shear conditions (ULS vs. oscillatory shear mimicking d-flow). We found 94 downregulated and 40 upregulated genes that changed in a shear- and SOX13-dependent manner. Several cytokines, including CXCL10 and CCL5, were the most strongly upregulated genes in HAECs treated with SOX13 siRNA. The robust induction of CXCL10 and CCL5 was further validated by qPCR and ELISA in HAECs. Moreover, the treatment of HAECs with Met-CCL5, a specific CCL5 receptor antagonist, prevented the endothelial inflammation responses induced by siSOX13. In addition, SOX13 overexpression prevented the endothelial inflammation responses. In summary, SOX13 is a novel conserved FSTF, which represses the expression of pro-inflammatory chemokines in ECs under s-flow. Reduction of endothelial SOX13 triggers chemokine expression and inflammatory responses, a major proatherogenic pathway.
Physics in the mesosphere/lower thermosphere: A personal perspective

The scope of this paper is to present some progress being made in the last few decades regarding some aspects of physical processes in the mesosphere/lower thermosphere and to point to some open questions. This summary is presented from a personal perspective, i.e., this is not a review of a certain science topic. Most citations reflect my own work or are representative examples only. They are not meant to be complete or comprehensive.
Bovine milk with variant β-casein types on immunological mediated intestinal changes and gut health of mice

Dietary proteins provide bioactive peptides, which are important for host gastrointestinal functions. We hypothesized that A2-type β-casein could provide gastrointestinal benefits and improve the immune and gut health. This study was conducted to investigate those effects and mechanisms. Thirty BALB-c mice (3–4 weeks old) were fed with either a control diet (control), a diet supplemented with bovine milk containing A1 and A2 type β-casein (A1A2, contains 63.62% A2 β-casein of total β-casein) or a diet containing A2 type β-casein (A2A2, contains 95.96% A2 β-casein of total β-casein) (10 ml/kg body weight) for 4 weeks. Immunoglobulin and inflammation factors were measured in serum, and histological variations were measured in duodenal and ileum, and stool 16S rRNA and short-chain fatty acids (SCFAs) contents were measured in fecal samples. Results showed that consumption of A2-type β-casein milk could improve proximal small intestine villus and crypt morphology (p < 0.05), increase IgG and IgE responses, and modulate the composition and diversity of gut microbiota by increase the relative abundance of phylum Proteobacteria, class Clostridia, family Ruminococcaceae and species Lactobacillus animalis (p < 0.05). There were also significant associations between gut microbes, immune response, and SCFAs, especially isobutyric acid (p < 0.05), which may potentially regulated gastrointestinal benefits. Moreover, intake of A2-type β-casein milk had no impact on inflammation. These findings explained potential benefits of consumption of A2-type β-casein milk on host immune system and gut health outcomes, and provide insights to the future application of nutritional modulation.
Combined biophysical and genetic modelling approaches reveal new insights into population connectivity of New Zealand green-lipped mussels

Understanding how ocean currents affect larval transport is crucial for understanding population connectivity in sessile marine invertebrates whose primary dispersal opportunity occurs during the pelagic larval stage. This study used Lagrangian particle tracking experiments to examine population connectivity in New Zealand green-lipped mussels (Perna canaliculus) at the national scale. Predicted patterns of larval dispersal were compared to published multi-locus microsatellite data of observed population genetic structure. Estimates of oceanographic circulation correlated significantly with FST, and we conclude that hydrodynamic processes are important in driving genetic connectivity. However, no evidence was found for an oceanographic barrier to gene flow south of Cook Strait, an important feature of genetic structure observed across several marine invertebrate species. Discrepancies between genetic and biophysical data may be explained by several factors including the different timescales of connectivity described by the two methods and the impact of localised ecological conditions and corresponding adaptations in genetic structure not captured by the bipohysical model. Population genetic analyses provide empirical data on realised connectivity and Lagrangian particle tracking experiments reveal information about directionality and asymmetry of connections that often cannot be determined by molecular analyses alone, thus a multidisciplinary approach is recommended.
The relationship between parental phubbing and learning burnout of elementary and secondary school students: The mediating roles of parent-child attachment and ego depletion

In this study, we examined the effects of parental phubbing on learning burnout in elementary and secondary school students and its mechanism of action. A questionnaire method was applied to investigate parental phubbing, parent–child attachment, ego depletion, and learning burnout among 2090 elementary and secondary school students in Anhui Province, China. The results are as follows: (1) Parental phubbing was significantly correlated with parent–child attachment, ego depletion, and learning burnout; (2) Parental phubbing has an indirect impact on learning burnout in elementary and secondary school students through three pathways: a separate mediating effect on parent–child attachment, a separate mediating effect on ego depletion, and a chain mediating effect on both. Parental phubbing is a risk factor for Learning Burnout, which can positively affect Learning Burnout in elementary and secondary school students. The findings of the study contribute to revealing the influence mechanism of parental phubbing on learning burnout in elementary and secondary school students.