Miracle-dz/UniFAR-FTUs huggingface dataset:
Nonparenchymal Cells Involves Functional TLR4 Signaling in Hepatic Ischemia/Reperfusion Injury

2 Endogenous ligands from damaged cells, so-called damage-associated molecular pattern molecules, can activate innate immunity via TLR4 signaling. Hepatic warm ischemia and reperfusion (I/R) injury and inﬂammation is largely TLR4 dependent. We produced TLR4 chimeric mice to assess whether the TLR4-dependent injury required TLR4 expression on liver parenchymal or nonparenchymal cells. Chimeric mice were produced by adoptive transfer of donor bone marrow cells into irradiated recipient animals using reciprocal combinations of TLR4 wild-type (WT; C3H/HeOuj) and TLR4 mutant (C3H/HeJ) mouse bone marrow. Wild-type chimeric mice bearing TLR4 mutant hemopoietic cells and TLR4 mutant mice transplanted with their own bone marrow-derived cells were protected from hepatic I/R and exhibited decreased JNK and NF- (cid:1) B activation compared with WT chimeric mice transplanted with their own bone marrow. In contrast, TLR4 mutant mice transplanted with TLR4 WT bone marrow were not protected from liver I/R and demonstrated pronounced increases in JNK and NF- (cid:1) B activation when compared with autochthonous transplanted mutant mice. In addition, depletion of phagocytes taking up gadolinium chloride failed to provide any additional protection to TLR4 mutant mice, but substantially reduced damage in WT mice after hepatic I/R. To-gether, these results demonstrate that TLR4 engagement on actively phagocytic nonparenchymal cells such as Kupffer cells is required for warm I/R-induced injury and inﬂammation in the liver. The Journal of Immunology, 2005, 175: 7661–7668.
Broadband and Wide-Angle Performance of a Perfect Absorber Using a MIM Structure with 2D MXene

Due to the extraordinary optoelectronic properties and surface-rich functional groups, MXene has shown great promise in many applications, such as electromagnetic shielding, catalysis, sensors, ultrafast photons, etc. In this work, we propose a wide-angle absorber based on a metal-insulator-metal (MIM) metamaterial consisting of MXene. By optimizing the design, the absorption efficiency can be further improved throughout the entire wavelength range. More importantly, the absorber exhibits high-efficiency broadband and wide-angle (20–80°) absorption in the near-infrared range (NIR: 1.1–1.7 μm) by numerical calculation. It is foreseeable that the excellent absorption characteristics and easy-to-manufacture structure of the designed absorber will bring some inspiration to the absorption device in the NIR and its practical application.
Rutin-stevioside and related conjugates for potential control of grapevine trunk diseases

Flavonoids and phenolic acids play roles in grapevine defence against pathogens causing grapevine trunk diseases (GTDs). Rutin is a major flavonoid in vegetative organs of the grapevines, and this compound, unlike other flavonoids, is non-toxic and non-oxidizable. Rutin was assayed in vitro and in vivo against two Botryosphaeriaceae taxa. The limited bioavailability of this compound was circumvented by conjugation with stevioside, a glycoside obtained from Stevia rebaudiana. Clear synergistic effects were observed for the stevioside-rutin adduct, resulting in EC50 and EC90 values of 306.0 and 714.9 μg·mL-1 against Neofusicoccum parvum and 241.6 and 457.8 μg·mL-1 against Dothiorella viticola. In greenhouse experiments, moderate inhibition of N. parvum growth and complete inhibition of D. viticola were observed. These inhibitory effects were greater than those of ferulic acid, which has been considered the most effective phenolic acid against GTDs. Conjugation with stevioside provided solubility enhancement of rutin, paving the way to the design of glycopesticides based on rutin-rich plant extracts as promising antifungals against GTDs.
A 4-month prospective study of the relationship between emotional intelligence and suicide ideation in Spanish adolescents: The mediating role of positive and negative affect

Abstract This research examined the relationships among emotional intelligence, positive and negative affect, and suicide ideation between Spanish adolescents in a 4-month follow-up study. Adolescents (N = 1,174) from Southern Spain completed an emotional intelligence scale and, 4 months later, 818 of them completed scales measuring affect and suicide ideation. Mediation analyses revealed that both positive and negative affect were significant partial mediators of the prospective relationship between emotional intelligence and suicide ideation. Overall, our findings support the role of emotional intelligence in suicidal thoughts, suggesting that emotional intelligence may reduce suicide ideation in part through its effects on affectivity.
Novel All-Nitrogen Molecular Crystals Composed of Tetragonal N4 Molecules

A computational study promises insight into molecular crystals consisting of the tetrahedral form of N4 molecules (Td-N4). Here, our efforts are focused on theoretically predicting the existence of the molecular crystals consisting of Td-N4 molecules. On the basis of the first principles of Born–Oppenheimer molecular dynamics under constant temperature and pressure, and geometry optimizations under hydrostatic pressures without any constrained parameters, molecular crystals consisting of Td-N4 molecules were confirmed to be dynamically and thermally metastable. Our analysis shows that, with high detonation performance and high stability, these Td-N4 molecular crystals can indeed be potential candidates as high-energy density explosives.
Analysis and Design for a High Power Density Three-Phase AC Converter Using SiC Devices

The development of a high-power-density three-phase ac converter has been a hot topic in power electronics due to the increasing need in applications like electric vehicles, aircraft and aerospace, where light weight and/or a low volume is usually a must. There are many challenges due to the complicated relationships in a three-phase power converter system. In addition, with the emerging SiC device technology, the operating frequency of the converter can be potentially pushed to tens of kHz to hundreds of kHz at high-voltages and high-power conditions. The extended frequency range brings opportunities to further improve the power density of the converter. The technologies based on existing devices need to be revisited. In this dissertation, a systematic methodology to analyze and design a high-powerdensity three-phase ac converter is developed. All the key factors of the converter design are investigated with the goal of high power density. The dissertation is divided into five sections. Firstly, the criteria for passive filter selection are derived, and the relationship between the switching frequency and the size of the EMI filter is investigated. A functional integration concept is proposed together with the physical design approach. Secondly, a topology evaluation method is presented, which provides insight into the relationships between the system constraints, operating conditions and design variables. Four topologies are then compared with the proposed approach, culminating with a preferred topology under the given conditions. Thirdly, a novel average model is developed for the selected topology, and is used for devising a carrier-based control approach with simple calculations and good regulation performance. Fourthly, the converter failure mode operation and corresponding protection approaches are discussed and developed. Finally, a 10 kW three-phase ac/ac converter is built with the SiC devices. All the key concepts and ideas developed in this work are implemented in this hardware system and then verified by the experimental results.
Cognitive–Behavioral Treatment of Obsessive–Compulsive Disorder: The Results of a Naturalistic Outcomes Study

Cognitive–behavioral therapy is a well-established treatment for obsessive–compulsive disorder (OCD). There are a variety of cognitive and behavioral strategies, and it is necessary to analyze the outcomes of the treatments. The aim of the present study is to verify the effectiveness of a treatment that combines evidence-based procedures and specific cognitive interventions highlighting the issue of acceptance. Forty patients with OCD were recruited and underwent a specific treatment procedure. All patients had a psychodiagnostic assessment for OCD using the Y–BOCS (Yale–Brown obsessive–compulsive scale) performed twice: before treatment (t0) and after nine months (t1). Data analysis showed a decrease in the scores between t0 and t1 according to the Y–BOCS in terms of the interference, severity, and impairment of obsessive–compulsive symptoms. A repeated-measures ANOVA showed a significant reduction in symptoms after treatment, with values of F (1, 39) = 137.56, p < 0.001, and η2 = 0.78. The ANOVA results were corroborated by a Wilcoxon signed-rank test. A reliable change index analysis indicated that 33 participants reported improvements in symptoms, of which 23 were clinically significant. The results showed clinical relevance for OCD treatment and highlighted how this cognitive procedure favored positive outcomes.
MicroRNA-299a-5p Protects against Spinal Cord Injury through Activating AMPK Pathway

Objective Inflammation and oxidative stress are implicated in the pathogenesis of spinal cord injury (SCI). The present study is aimed at investigating the function and molecular basis of microRNA-299a-5p (miR-299a-5p) during SCI in mice. Methods Mice were exposed to SCI surgery and then intrathecally injected with the agomir, antagomir, or matched negative controls of miR-299a-5p to overexpress or silence miR-299a-5p. To inhibit AMP-activated protein kinase (AMPK), mice were intraperitoneally injected with compound C (CC). To overexpress pH domain and leucine-rich repeat protein phosphatase 1 (PHLPP1), lentiviral vectors were used. Results The miR-299a-5p expression in the spinal cord was dramatically reduced by SCI stimulation. The miR-299a-5p agomir prevents, while the miR-299a-5p antagomir exacerbates inflammation, oxidative stress, and SCI in mice. Mechanistically, we found that miR-299a-5p directly inhibited PHLPP1 and subsequently activated AMPK pathway. The PHLPP1 overexpression of AMPK inhibition with either genetic or pharmacologic methods dramatically abolished the miR-299a-5p agomir-mediated protective effects against SCI. Conclusion miR-299a-5p protects against spinal cord injury through activating AMPK pathway.
Association of Circulating IgE and CML Levels with In-Stent Restenosis in Type 2 Diabetic Patients with Stable Coronary Artery Disease

Background: We investigated whether serum levels of immunoglobin (Ig) E and Nε-carboxymethyl-lysine (CML) are related to in-stent restenosis (ISR) in patients with stable coronary artery disease and type 2 diabetes mellitus (T2DM). Methods: Serum levels of IgE and CML were measured in 196 ISR patients and 220 non-ISR patients with stable angina and T2DM who received angiographic follow-up 12 months after percutaneous coronary intervention (PCI) with third-generation drug-eluting stent (DES) implantation for de novo lesions. Multivariate logistic regression analysis was performed to assess the association between IgE or CML and ISR. Results: Both IgE and CML levels were higher in patients with ISR compared with non-ISR patients (IgE: 187.10 (63.75–489.65) vs. 80.25 (30.65–202.50), p < 0.001; CML: 203.26 (164.50–266.84) vs. 174.26 (130.85–215.56), p < 0.001). The rate of ISR increased stepwise with increasing tertiles of IgE and CML levels (p for all trends < 0.001), and IgE correlated significantly with CML. After adjusting for potential confounders, IgE and CML levels remained independently associated with ISR. Moreover, IgE and CML levels improved the predictive capability of traditional risk factors for ISR, and there existed an interaction between IgE and CML in relation to ISR (p for interaction < 0.01). Conclusion: Elevated circulating IgE and CML levels confer an increased risk for ISR after DES-based PCI in type 2 diabetic patients with stable coronary artery disease.
Antimicrobial Activities and Phytochemical Screening of the Solvent fractions of the Leaves and Stems of Leea guineensis G. Don

Aim: We evaluated the antibacterial activities and phytochemical distribution of the solvent fractions of the leaf and stem of Leea guineensis G. Don. Methodology: The antibacterial activities and phytochemical distribution of the solvent fractions of the leaf and stem of L. guineensis were determined using standard procedures. Results: Methanol fraction of the leaves at 100 mg/mL showed activity against Acinetobacter baumammii while both ethyl acetate and methanol fractions of the leaves at 100 mg/mL have activities against Acinetobacter baumammii. The methanol fraction of LGS leaves at 25-100 mg/mL was potent against Escherichia coli, while the ethyl acetate fraction of the stem at 100 mg/mL was inhibitory to Escherichia coli. Both the ethyl acetate and methanol fractions of the leaf of LGS possess antibacterial activity against Staphylococcus aureus, however, the methanol fractions of the stem alone inhibit Staphylococcus aureus. Ethyl acetate and methanol fractions of the leaf were inhibitory to Pseudomonas aeruginosa while ethyl acetate fraction of the stem was highly efficacious on Pseudomonas aeruginosa. Only the methanol fraction of the leaf was potent against Proteus mirabilis, while both ethyl acetate and methanol fraction of the stem were potent against Proteus mirabilis. Both ethyl acetate and methanol fractions of the stem at 100 µg/mL were potent against Klebsiella pneumoniae but, only the methanol fraction of the stem was potent on Klebsiella pneumoniae. The methanol fraction of the leaves was potent against Salmonella Typhi however, both ethyl acetate and methanol fraction of the stem were potent against Salmonella Typhi. More phytochemicals were found in ethyl acetate and methanol fractions of both the leaves and stems. Conclusion: The ethyl acetate and methanol fractions of the leaves and stem of L. guineensis seem to possess some antibacterial properties courtesy of the abundant phytochemicals found in these fractions.
J OURNAL OF I NFORMATION T ECHNOLOGY T HEORY AND A PPLICATION

: We develop a design method that promotes flexible component design based on a common component platform with various plug-ins. The approach increases the flexibility and expandability of software components, which improves their reuse opportunities. We argue that such a flexible component design can expand reuse from relatively small infrastructure items, such as user interfaces, printing functionality, and data access modules, to the core of the application domain. Reusing such domain-specific items helps realize the true value of component-based software development. Following a design science research approach, we evaluated the component design method by assessing its correctness and its application to different scenarios. We also recruited a panel of experts to assess it.
Non‐orthogonal multiple access in backscatter communication system under the scene of the moving reader

This article studies non‐orthogonal multiple access (NOMA) backscatter communication (BackCom) system under the scene of the moving reader. As the reader moves, the communication link between backscatter nodes (BNs) and the reader is dynamic, and the computational complexity of regrouping is high. To address these problems, a dynamic NOMA‐BackCom scheme is proposed, which consists of a dynamic multiplexing BNs scheme and a dynamic scheme of choosing the reflection coefficient. Moreover, a performance evaluation is conducted to compare the decoding rate of the proposed scheme and the traditional scheme. Simulation results show that the proposed scheme has higher decoding rate and better throughput than the traditional scheme.
How Critical Thinking Skills Influence Misconception in Electric Field

This study aimed to determine the influence of critical thinking skills on misconceptions using a five-tier instrument in mixed-method research. The sampling technique used is simple random sampling. The data collection instrument used a critical thinking skills questionnaire, a misconception test of electric field material, and interviews. Data collection begins with quantitative data, providing a misconception test sheet and a critical thinking skills questionnaire. After that, the researcher took qualitative data in the form of interviews to strengthen data that had been obtained previously. Then from the results of the regression coefficients, there is an influence of critical thinking skills on misconceptions. The descriptive results of critical thinking skills data show that the mean of critical thinking skills is 68.50, which means that students' critical thinking skills are in a good category. Then from the results of the regression coefficients, there is an effect of critical thinking skills on a misconception, with the probability number obtained being significant. The limitations of this study are only to identify and see the impact.
Egg rejection based on egg size recognition as a specific strategy against parasitic cuckoos

Abstract In the coevolutionary interactions between avian brood parasites and their hosts, egg recognition based on color and/or pattern is a common and effective defense to counter parasitism. However, for egg recognition based on size, only a few studies have found affirmative results, and they do not provide unambiguous evidence that egg size recognition in hosts has evolved as an important and specific anti-parasite adaptation against parasite eggs. We studied the brood parasite system between the Asian emerald cuckoo Chrysococcyx maculatus and its host, the chestnut-crowned warbler Phylloscopus castaniceps. The cuckoo parasitizes the warbler using non-mimetic and larger eggs at a parasitism rate of 12.9%. The warbler nests used in this experiment were built in a dark environment with the nest illuminance near 0 lux. Experiments with 2 types of model eggs with colors and patterns resembling cuckoo eggs of different sizes (cuckoo egg size or host egg size) showed that the warblers were able to reject 63.6% of cuckoo model eggs under these dim light conditions. However, model eggs with the same color and pattern similar to the warbler egg size were always accepted. This study provides strong evidence supporting the theory that egg size recognition can be evolved in hosts as a specific anti-parasite adaptation against cuckoos. We suggest that the egg size recognition of the warbler is an outcome of the tradeoff between the costs of violating the parental investment rule and suffering cuckoo parasitism.
Effects of Health-Related Behaviors and Changes on Successful Aging among Indonesian Older People

Whether changes in health behaviors can improve successful aging has not been well explored. The purpose of this study was to assess the effects of health-related behaviors and changes on successful aging in Indonesian older adults. Data were from the fourth and fifth waves of the Indonesia Family Life Survey (IFLS), the participants were aged 60 years and older and who completed both waves (n = 1289). Successful aging indicators were defined as no chronic diseases, no physical function difficulties, no depressive symptoms, intact cognitive function, with social support, and with social participation. Health-related behaviors focused on smoking, physical activities, and protein intake. A logistic regression analysis was conducted. The overall successful aging rate in 2007 was 23.6%, and it had decreased to 5.6% by 2014. There were gender differences in smoking, physical activities, and behavioral changes, including promoting increased physical activity, no smoking/smoking cessation, and adequate protein intake by older adults. Quitting smoking, performing medium physical activity, and increasing protein intake were protective factors for successful aging, but the effects of behavioral changes differed by gender. Health-related behaviors and changes may impact successful aging among older adults. A healthy lifestyle is suggested to be adopted as early as possible in one’s life course.
Large-Scale Profiling of Extracellular Vesicles Identified miR-625-5p as a Novel Biomarker of Immunotherapy Response in Advanced Non-Small-Cell Lung Cancer Patients

Simple Summary Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced non-small-cell lung cancer (NSCLC) leading to substantial improvement in survival time and quality of life. Nevertheless, the clinical benefit of treatment is still limited to a minority of patients, reflecting the need to identify novel noninvasive biomarkers to improve patient selection. Currently available markers such as PD-L1 expression have important limitations. In this study, we focused on extracellular vesicles (EV)-associated miRNAs produced by cancer cells and their microenvironment that can be easily detected in blood. In particular, after a large-scale screening of 799 EV-miRNAs, we identified EV-miR-625-5p as a novel independent biomarker of response and survival in ICI-treated NSCLC patients, in particular in patients with PD-L1 expression ≥ 50%. EV-miR-625-5p integrated with PDL-1 test could allow the clinician to identify in advance patients that would benefit from ICIs. Abstract Immune checkpoint inhibitors (ICIs) are largely used in the treatment of patients with advanced non-small-cell lung cancer (NSCLC). Novel biomarkers that provide biological information that could be useful for clinical management are needed. In this respect, extracellular vesicles (EV)-associated microRNAs (miRNAs) that are the principal vehicle of intercellular communication may be important sources of biomarkers. We analyzed the levels of 799 EV-miRNAs in the pretreatment plasma of 88 advanced NSCLC patients who received anti-PD-1 therapy as single agent. After data normalization, we used a two-step approach to identify candidate biomarkers associated to both objective response (OR) by RECIST and longer overall survival (OS). Univariate and multivariate analyses including known clinicopathologic variables and new findings were performed. In our cohort, 24/88 (27.3%) patients showed OR by RECIST. Median OS in the whole cohort was 11.5 months. In total, 196 EV-miRNAs out 799 were selected as expressed above background. After multiplicity adjustment, abundance of EV-miR-625-5p was found to be correlated with PD-L1 expression and significantly associated to OR by RECIST (p = 0.0366) and OS (p = 0.0031). In multivariate analysis, PD-L1 staining and EV-miR-625-5p levels were constantly associated to OR and OS. Finally, we showed that EV-miR-625-5p levels could discriminate patients with longer survival, in particular in the class expressing PD-L1 ≥50%. EV-miRNAs represent a source of relevant biomarkers. EV-miR-625-5p is an independent biomarker of response and survival in ICI-treated NSCLC patients, in particular in patients with PD-L1 expression ≥50%.