Miracle-dz/UniFAR-FTUs huggingface dataset:
Convergent evolution of cytochrome P450s underlies independent origins of keto-carotenoid pigmentation in animals

Keto-carotenoids contribute to many important traits in animals, including vision and coloration. In a great number of animal species, keto-carotenoids are endogenously produced from carotenoids by carotenoid ketolases. Despite the ubiquity and functional importance of keto-carotenoids in animals, the underlying genetic architectures of their production have remained enigmatic. The body and eye colorations of spider mites (Arthropoda: Chelicerata) are determined by β-carotene and keto-carotenoid derivatives. Here, we focus on a carotenoid pigment mutant of the spider mite Tetranychus kanzawai that, as shown by chromatography, lost the ability to produce keto-carotenoids. We employed bulked segregant analysis and linked the causal locus to a single narrow genomic interval. The causal mutation was fine-mapped to a minimal candidate region that held only one complete gene, the cytochrome P450 monooxygenase CYP384A1, of the CYP3 clan. Using a number of genomic approaches, we revealed that an inactivating deletion in the fourth exon of CYP384A1 caused the aberrant pigmentation. Phylogenetic analysis indicated that CYP384A1 is orthologous across mite species of the ancient Trombidiformes order where carotenoids typify eye and body coloration, suggesting a deeply conserved function of CYP384A1 as a carotenoid ketolase. Previously, CYP2J19, a cytochrome P450 of the CYP2 clan, has been identified as a carotenoid ketolase in birds and turtles. Our study shows that selection for endogenous production of keto-carotenoids led to convergent evolution, whereby cytochrome P450s were independently co-opted in vertebrate and invertebrate animal lineages.
Inferring strings from position heaps in linear time

Position heaps are index structures of text strings used for the string matching problem. They are rooted trees whose edges and nodes are labeled and numbered, respectively. This paper is concerned with variants of the inverse problem of position heap construction and gives linear-time algorithms for those problems. The basic problem is to restore a text string from a rooted tree with labeled edges and numbered nodes. In the variant problems, the input trees may miss edge labels or node numbers which we must restore as well.
Incidental Learning: A Systematic Review of Its Effect on Episodic Memory Performance in Older Age

Episodic memory is the capacity to encode, store, and retrieve information of specific past events. Several studies have shown that the decline in episodic memory accompanies aging, but most of these studies assessed memory performance through intentional learning. In this approach, the individuals deliberately acquire knowledge. Yet, another method to evaluate episodic memory performance–receiving less attention by the research community–is incidental learning. Here, participants do not explicitly intent to learn. Incidental learning becomes increasingly important over the lifespan, since people spend less time in institutions where intentional learning is required (e.g., school, university, or at work). Yet, we know little how incidental learning impacts episodic memory performance in advanced age. Likewise, the neural mechanisms underlying incidental learning in older age remain largely unknown. Thus, the immediate goal of this review was to summarize the existing literature on how incidental learning changes with age and how neural mechanisms map onto these age-related changes. We considered behavioral as well as neuroimaging studies using incidental learning paradigms (alone or in combination with intentional learning) to assess episodic memory performance in elderly adults. We conducted a systematic literature search on the Medline/PubMed, Cochrane, and OVID SP databases and searched the reference lists of articles. The search yielded 245 studies, of which 34 concerned incidental learning and episodic memory in older adults. In sum, these studies suggest that aging particularly affects episodic memory after incidental learning for cognitively demanding tasks. Monitoring deficits in older adults might account for these findings since cognitively demanding tasks need increased attentional resources. On a neuronal level, dysregulation of the default-mode-network mirrors monitoring deficits, with an attempt to compensate through increased frontal activity. Future (neuroimaging) studies should systematically evaluate retrieval tasks with diverging cognitive load and consider the influence of attention and executive functions in more detail.
SAMEE : the nonlinear adaptive method for predicting work effort of information systems development

At the early stage of information system analysis and design one of the challenge is to estimate total work effort needed, when only small number of analysis artifacts is available. As a solution we propose new method called SAMEE – Simple Adaptive Method for Effort Estimation. It is based on the idea of polynomial regression and uses selected UML artifacts like use cases, actors, domain classes and references between them. In this paper we describe implementation of this method in Enterprise Architect CASE tool and show simple example how to use it in real information system analysis.
Electrospun Structures Made of a Hydrolyzed Keratin-Based Biomaterial for Development of in vitro Tissue Models

The aim of this study is the analysis and characterization of a hydrolyzed keratin-based biomaterial and its processing using electrospinning technology to develop in vitro tissue models. This biomaterial, extracted from poultry feathers, was mixed with type A porcine gelatin and cross-linked with γ-glycidyloxy-propyl-trimethoxy-silane (GPTMS) to be casted initially in the form of film and characterized in terms of swelling, contact angle, mechanical properties, and surface charge density. After these chemical-physical characterizations, electrospun nanofibers structures were manufactured and their mechanical properties were evaluated. Finally, cell response was analyzed by testing the efficacy of keratin-based structures in sustaining cell vitality and proliferation over 4 days of human epithelial, rat neuronal and human primary skin fibroblast cells.
Teramac: pointing the way to real-world nanotechnology

Researchers say that the ability to grow molecular sized electronic components-already being produced in research labs around the world-is expected to reach commercial economic and technical feasibility around the same time CMOS technology reaches its physical or economic limit (around 2010). A major goal of nanoscale technology is to build systems that incorporate a huge number of computational devices (researchers speak in terms of a mole, approximately 6/spl times/10/sup 23/). How will tomorrow's computer architects achieve the organization that allows the entire mass of devices to operate efficiently? Chemically assembled machines will certainly have to reproduce the arbitrary complexity that general purpose computation demands. Teramac, an experimental configurable computer built at the HP Lab, has demonstrated a viable solution to this problem. The powerful computer was originally designed to test different parallel computing architectures in the mid '90s, but has proven that a massively defect tolerant computer-that accommodates the uncertainty of "grown" computing devices-can be built.
A genetic approach to test generation for logic circuits

This paper presents a genetic algorithm to generate tests for logic circuits. Bit strings corresponding to primary input patterns are evolved into tests for detecting a target fault by genetic operations. Some new techniques, such as a crossover operation based on fault-excitability and fault-drivability, are introduced to achieve high fault coverage. Experimental results show that the genetic approach is effective for solving test generation problem. <<ETX>>
Understanding the Role of Psychological Capital in Humorous Leadership-Employee Creativity Relations

This paper aims to examine how humorous leadership enhances employee workplace creativity from a novel angle of employee psychological capital (EPC). This study also explores the moderating roles of supervisor-subordinate dyadic tenure and work autonomy in the proposed model. Data from a sample of 355 supervisor-subordinate dyads working in an information technology enterprise in the People’s Republic of China was used to test the assumed moderated mediation model. The results indicate the positive relationship between humorous leadership and employee workplace creativity, which is partially mediated by EPC. Moreover, work autonomy significantly moderates the relationship between EPC and employee creativity. Humorous leadership has a significant effect on the extra role behavior of subordinates, leading to workplace creativity. The deliberate establishment of a humorous image by leaders may encourage subordinates to achieve creative goals. Combined with traditional management practices that emphasize the supportive behaviors of leaders, leaders can use humor to provide an open and friendly atmosphere for employees, thereby encouraging creativity in the workplace. Organizations should also place greater emphasis on employee work autonomy, giving employees enough flexibility on when and how they deal with their work; this could enhance the positive impact of other factors on employee workplace creativity. These findings carry implications for research on humorous leadership, EPC, and creativity.
Immature Oocyte for Fertility Preservation

In vitro maturation (IVM) of human immature oocytes has been offered to women who are at risk of developing ovarian hyperstimulation syndrome (OHSS) caused by gonadotropin stimulation, such as PCO(S) patients or who have poor ovarian reserve. Cryopreservation of oocytes matured in vivo obtained in IVF cycles has improved after implementing the vitrification method and many successful results have been reported. Now, this procedure can be successfully offered to fertility preservation programs for patients who are in danger of losing their ovarian function due to medical or social reasons, and to oocyte donation programs. This vitrification technique has also been applied to cryopreserve oocytes obtained from IVM program. Some advantages of oocytes vitrification related with IVM are: (1) eliminating costly drugs and frequent monitoring; (2) completing treatment within 2 to 10 days (3) avoiding the use of hormones in cancer patients with hormone-sensitive tumors; and (4) retrieving oocytes at any point in menstrual cycle, even in the luteal phase. In addition, immature oocytes can also be collected from extracorporeal ovarian biopsy specimens or ovaries during caesarian section. Theoretically, there are two possible approaches for preserving immature oocytes: oocyte cryopreservation at the mature stage (after IVM) and oocyte cryopreservation at the Germinal Vesicle (GV)-stage (before IVM). Both vitrification of immature oocyte before/after IVM is not currently satisfactory. Nevertheless, many IVF centers worldwide are doing IVM oocyte cryopreservation as one of the options to preserve fertility for female cancer. Therefore, more studies are urgently required to improve IVM- and vitrification method to successfully preserve oocytes collected from cancer patients. In this review, present oocyte maturation mechanisms and recent progress of human IVM cycles will be discussed first, followed by some studies of the vitrification of human IVM oocyte.
Harmonizing, annotating and sharing data in biodiversity–ecosystem functioning research

The integrative research field of biodiversity–ecosystem functioning (BEF) requires close collaboration between researchers from different disciplines working on different scales in time, space as well as taxon resolution. Data can describe anything from abiotic ecosystem components, to organisms, parts of organisms, genetic information or element stocks and flows. Researchers prefer the convenience of spreadsheets for data preparation, which can lead to isolated data sets that are diverse in structure and follow diverging naming conventions. BEFdata (https://github.com/befdata/befdata) is a new, open source web platform for the upload, validation and storage of data from a formatted Excel workbook. Metadata can be downloaded in Ecological Metadata Language (EML). BEFdata allows the harmonization of naming conventions by generating category lists from the primary data, which can be reviewed and managed via the Excel workbook or directly on the platform. BEFdata provides a secure environment during ongoing analysis; project members can only access primary data from other researchers after the acceptance of a data request. Due to its generic database schema, BEFdata platforms can be used for any research domain working with tabular data. It supports the compilation of coherent data sets at the level of the primary data, allowing researchers to explicitly model correlation structures across data sets for synthesis. The EML export enables efficient publishing of data in global repositories.
Mosquitoes cloak their legs to resist insecticides

Malaria incidence has halved since the year 2000, with 80% of the reduction attributable to the use of insecticides. However, insecticide resistance is now widespread, is rapidly increasing in spectrum and intensity across Africa, and may be contributing to the increase of malaria incidence in 2018. The role of detoxification enzymes and target site mutations has been documented in the major malaria vector Anopheles gambiae; however, the emergence of striking resistant phenotypes suggests the occurrence of additional mechanisms. By comparing legs, the most relevant insect tissue for insecticide uptake, we show that resistant mosquitoes largely remodel their leg cuticles via enhanced deposition of cuticular proteins and chitin, corroborating a leg-thickening phenotype. Moreover, we show that resistant female mosquitoes seal their leg cuticles with higher total and different relative amounts of cuticular hydrocarbons, compared with susceptible ones. The structural and functional alterations in Anopheles female mosquito legs are associated with a reduced uptake of insecticides, substantially contributing to the resistance phenotype.
Differential Effects of Sustained Manual Pressure Stimulation According to Site of Action

Sustained pressure stimulation of the body surface has been used in several physiotherapeutic techniques, such as reflex locomotion therapy. Clinical observations of global motor responses and subsequent motor behavioral changes after stimulation in certain sites suggest modulation of central sensorimotor control, however, the neuroanatomical correlates remain undescribed. We hypothesized that different body sites would specifically influence the sensorimotor system during the stimulation. We tested the hypothesis using functional magnetic resonance imaging (fMRI) in thirty healthy volunteers (mean age 24.2) scanned twice during intermittent manual pressure stimulation, once at the right lateral heel according to reflex locomotion therapy, and once at the right lateral ankle (control site). A flexible modeling approach with finite impulse response basis functions was employed since non-canonical hemodynamic response was expected. Subsequently, a clustering algorithm was used to separate areas with differential timecourses. Stimulation at both sites induced responses throughout the sensorimotor system that could be mostly separated into two anti-correlated subsystems with transient positive or negative signal change and rapid adaptation, although in heel stimulation, insulo-opercular cortices and pons showed sustained activation. In direct voxel-wise comparison, heel stimulation was associated with significantly higher activation levels in the contralateral primary motor cortex and decreased activation in the posterior parietal cortex. Thus, we demonstrate that the manual pressure stimulation affects multiple brain structures involved in motor control and the choice of stimulation site impacts the shape and amplitude of the blood oxygenation level-dependent response. We further discuss the relationship between the affected structures and behavioral changes after reflex locomotion therapy.
Secure Computation for Cloud data Storage

One of the main goals of securing data transmission is focused on the security of cloud data storage. In this paper, we describe several cryptographic techniques which can be used to address the relevant threats and security goals for analyzing cloud computing security. Private semi-trusted clouds, allow researchers to design private clouds by using cryptographic techniques, to protect the semi-trusted ones. Finally, we elaborate on semi-trusted clouds which are related to real-world deployments of cloud resources, and how optimizing cryptographic protocols, would indeed lead to the usage of this certain cloud and therefore practical ways of securing this type of data.
A 2.5 GHz All-Digital Delay-Locked Loop in 0.13 $\mu{\hbox {m}}$ CMOS Technology

A 2.5 GHz, 30 mW, 0.03 mm2, all-digital delay-locked loop (ADDLL) in 0.13 mum CMOS technology is presented. The tri-state digital phase detector suppresses the dithering phenomenon and reduces the output peak-to-peak jitter for a counter-controlled digital DLL. The lattice delay unit has both a small delay step and a fixed intrinsic delay of two nand gates. A modified successive approximation register-controller reduces the locking time and allows the DLL to track the process, voltage, temperature, and load variations. This ADDLL locks in 24 cycles and has a closed-loop characteristic. The measured peak-to-peak jitter is 14 ps at 2.5 GHz.
Comparing methods for the multi‐response design problem

One approach to solving multiple response engineering problems is to combine the individual responses into one unifying objective. In tility theory, several characteristics are used to compare and contrast multiple objective techniques. These are risk aversion, marginal rates of substitution, and the relationship of the responses in the combined function. Perhaps unknown to the user, multiple response techniques carry strong assumptions regarding these characteristics. This paper investigates four commonly‐used multiple objective techniques and demonstrates that each method contains assumptions about these characteristics which are not intuitively evident to a user. Copyright © 2001 John Wiley & Sons, Ltd
Brain and Head-and-Neck MRI in Immobilization Mask: A Practical Solution for MR-Only Radiotherapy

In brain/head-and-neck radiotherapy (RT), thermoplastic immobilization masks guarantee reproducible patient positioning in treatment position between MRI, CT, and irradiation. Since immobilization masks do not fit in the diagnostic MR head/head-and-neck coils, flexible surface coils are used for MRI imaging in clinical practice. These coils are placed around the head/neck, in contact with the immobilization masks. However, the positioning of these flexible coils is technician dependent, thus leading to poor image reproducibility. Additionally, flexible surface coils have an inferior signal-to-noise-ratio (SNR) compared to diagnostic coils. The aim of this work was to create a new immobilization setup which fits into the diagnostic MR coils in order to enhance MR image quality and reproducibility. For this purpose, a practical immobilization setup was constructed. The performances of the standard clinical and the proposed setups were compared with four tests: SNR, image quality, motion restriction, and reproducibility of inter-fraction subject positioning. The new immobilization setup resulted in 3.4 times higher SNR values on average than the standard setup, except directly below the flexible surface coils where similar SNR was observed. Overall, the image quality was superior for brain/head-and-neck images acquired with the proposed RT setup. Comparable motion restriction in feet-head/left-right directions (maximum motion ≈1 mm) and comparable inter-fraction repositioning accuracy (mean inter-fraction movement 1 ± 0.5 mm) were observed for the standard and the new setup.
Cognitive-Emotional and Inhibitory Deficits as a Window to Moral Decision-Making Difficulties Related to Exposure to Violence

In the present review, we illustrate how exposure to violence results in an increased probability of developing functional impairments of decision mechanisms necessary for moral behavior. We focus in particular on the detrimental effects of exposure to violence on emotional (e.g., Empathy), cognitive (e.g., Theory of Mind), and inhibitory control abilities. Relying on studies that document impaired moral behavior in individuals with deficits in these abilities, we propose a “model” of how exposure to violence can affect moral behavior. We then discuss how impaired moral decision making can also be a factor increasing the likelihood of reiterating violence: agents who lack abilities such as understanding and resonating with others’ emotions or inhibitory control, can lead to an increase of violent displays. Thus, if not properly addressed, the noxious effects of exposure to violence on morality can lead to a violence generating cycle. We conclude proposing that interventions targeted at improving moral behavior can maximize their efficacy focusing on mitigating the impact of violence on the basic cognitive, emotional, and inhibitory abilities discussed.
Human Detection Based on SVM and Improved Histogram of Oriented Gradients

Considering the fact that original histogram of oriented gradients (HOG) cannot extract the body local features in large image regions, its features are improved when extracted, then more gradient information are extracted and feature description operators can be obtained which describe human detail features better in lager image regions or detection windows. Considering speed, we select support vector machine (SVM) using linear function kernel as a classifier. Combining with HOG extraction and SVM training, the process includes three steps: features extraction, training and detection. Experiments show that while maintaining a relatively satisfactory speed the human detection system improves detection accuracy.
The Mechanisms of Disease Caused by Acinetobacter baumannii

Acinetobacter baumannii is a Gram negative opportunistic pathogen that has demonstrated a significant insurgence in the prevalence of infections over recent decades. With only a limited number of “traditional” virulence factors, the mechanisms underlying the success of this pathogen remain of great interest. Major advances have been made in the tools, reagents, and models to study A. baumannii pathogenesis, and this has resulted in a substantial increase in knowledge. This article provides a comprehensive review of the bacterial virulence factors, the host immune responses, and animal models applicable for the study of this important human pathogen. Collating the most recent evidence characterizing bacterial virulence factors, their cellular targets and genetic regulation, we have encompassed numerous aspects important to the success of this pathogen, including membrane proteins and cell surface adaptations promoting immune evasion, mechanisms for nutrient acquisition and community interactions. The role of innate and adaptive immune responses is reviewed and areas of paucity in our understanding are highlighted. Finally, with the vast expansion of available animal models over recent years, we have evaluated those suitable for use in the study of Acinetobacter disease, discussing their advantages and limitations.