Miracle-dz/UniFAR-FTUs huggingface dataset:
CHANDRA X-RAY AND HUBBLE SPACE TELESCOPE IMAGING OF OPTICALLY SELECTED KILOPARSEC-SCALE BINARY ACTIVE GALACTIC NUCLEI. II. HOST GALAXY MORPHOLOGY AND AGN ACTIVITY

Binary active galactic nuclei (AGNs) provide clues to how gas-rich mergers trigger and fuel AGNs and how supermassive black hole (SMBH) pairs evolve in a gas-rich environment. While significant effort has been invested in their identification, the detailed properties of binary AGNs and their host galaxies are still poorly constrained. In a companion paper, we examined the nature of ionizing sources in the double nuclei of four kiloparsec-scale binary AGNs with redshifts between 0.1 and 0.2. Here, we present their host galaxy morphology based on F336W (U-band) and F105W (Y-band) images taken by the Wide Field Camera 3 on board the Hubble Space Telescope. Our targets have double-peaked narrow emission lines and were confirmed to host binary AGNs with follow-up observations. We find that kiloparsec-scale binary AGNs occur in galaxy mergers with diverse morphological types. There are three major mergers with intermediate morphologies and a minor merger with a dominant disk component. We estimate the masses of the SMBHs from their host bulge stellar masses and obtain Eddington ratios for each AGN. Compared with a representative control sample drawn at the same redshift and stellar mass, the AGN luminosities and Eddington ratios of our binary AGNs are similar to those of single AGNs. The U − Y color maps indicate that clumpy star-forming regions could significantly affect the X-ray detection of binary AGNs, e.g., the hardness ratio. Considering the weak X-ray emission in AGNs triggered in merger systems, we suggest that samples of X-ray-selected AGNs may be biased against gas-rich mergers.
Fabrication of triangular Au/Ag nanoparticle arrays with sub-10 nm nanogap controlled by flexible substrate for surface-enhanced Raman scattering

Large-area ordered nanoparticle arrays have shown great potential as surface-enhanced Raman scattering (SERS) substrates. The preparation methods of metal nanogap with width greater than 10 nm are relatively mature. In contrast, nanomanufacturing methods for sub-10 nm still face challenges in realizing controllable and reproducible features. Herein, a series of triangular Au/Ag nanoparticle arrays (noted as Au/Ag NPAs) with sub-10 nm gap were prepared by utilizing stress-induced local cracking and high expansion coefficient of flexible polydimethylsiloxane (PDMS). The triangular tip-connected Au/Ag NPAs were firstly prepared by depositing Au and Ag films on home-made polystyrene (PS) templates, then gaps with precise size (3 nm, 5 nm, 7 nm, 9 nm and 11 nm) were achieved by controlling the temperature of flexible PDMS, and finally transferred to the silicon wafers using as SERS substrates. The results showed that when the prepared triangular Au/Ag NPAs with 3 nm nanogap were used as reliable SERS substrates, the relative standard deviation of Raman intensity at 621 cm−1 mode of Rhodamine 6G (R6G) with concentration of 10–6 M was 2.3%, indicating excellent uniformity. The approach showed good controllability and repeatability for SERS analysis, exhibiting good application prospect in surface trace detection.
Outcomes in PIC-Related CNV: Pooled Analysis of Individual Participant Data

ABSTRACT Choroidal neovascularization (CNV) affects 64–75% of eyes with punctate inner choroidopathy (PIC). Although anti-VEGF agents are considered first-line therapy, there is controversy regarding other modalities, such as immunosuppression. We performed a systematic review of individual participant data (IPD) and generated a dataset of 278 eyes with PIC-related CNV from 45 studies. Forty-two percent presented with moderate visual loss (MVL) or worse. Four different treatment modalities (anti-VEGF, photodynamic therapy, local immunosuppression, and systemic immunosuppression) and most combinations among them were represented. Anti-VEGF injections decreased the likelihood of MVL (Odds Ratio 0.3, p = .027), an effect moderated by presenting visual acuity and patient age. Eyes receiving more than 3 injections were more likely to receive additional therapeutic modalities. Increasing number of modalities was associated with longer follow-up time and did not improve vision. The beneficial effect of anti-VEGF injections persisted when controlling for presenting visual acuity and follow-up time.
Comprehensive clinicopathological characteristics and mucin core protein expression profiles of bronchiolar adenoma

Bronchiolar adenoma (BA) is a novel entity in the 2021 WHO classification of lung tumours. The expression profile of mucin core proteins in BAs is not clear. The aim of this study was to clarify the expression profiles of mucins and to validate the clinicopathologic and molecular features of BAs.
The northern corn leaf blight resistance gene Ht1 encodes an nucleotide‐binding, leucine‐rich repeat immune receptor

Abstract Northern corn leaf blight, caused by the fungal pathogen Exserohilum turcicum, is a major disease of maize. The first major locus conferring resistance to E. turcicum race 0, Ht1, was identified over 50 years ago, but the underlying gene has remained unknown. We employed a map‐based cloning strategy to identify the Ht1 causal gene, which was found to be a coiled‐coil nucleotide‐binding, leucine‐rich repeat (NLR) gene, which we named PH4GP‐Ht1. Transgenic testing confirmed that introducing the native PH4GP‐Ht1 sequence to a susceptible maize variety resulted in resistance to E. turcicum race 0. A survey of the maize nested association mapping genomes revealed that susceptible Ht1 alleles had very low to no expression of the gene. Overexpression of the susceptible B73 allele, however, did not result in resistant plants, indicating that sequence variations may underlie the difference between resistant and susceptible phenotypes. Modelling of the PH4GP‐Ht1 protein indicated that it has structural homology to the Arabidopsis NLR resistance gene ZAR1, and probably forms a similar homopentamer structure following activation. RNA sequencing data from an infection time course revealed that 1 week after inoculation there was a threefold reduction in fungal biomass in the PH4GP‐Ht1 transgenic plants compared to wild‐type plants. Furthermore, PH4GP‐Ht1 transgenics had significantly more inoculation‐responsive differentially expressed genes than wild‐type plants, with enrichment seen in genes associated with both defence and photosynthesis. These results demonstrate that the NLR PH4GP‐Ht1 is the causal gene underlying Ht1, which represents a different mode of action compared to the previously reported wall‐associated kinase northern corn leaf blight resistance gene Htn1/Ht2/Ht3.
Looking Under the Lamppost: The Search for New Cancer Targets in the Human Kinome

The number of cancer drugs is increasing as new chemical entities are developed to target molecules, often protein kinases, driving cancer progression. In 2009, Fedorov et al. identified that of the protein kinases in the human kinome, most of the focus has been on a small subset. They highlighted that many poorly investigated protein kinases were cancer drivers, but there was no relationship between publications and involvement in cancer development or progression. Since 2009, there has been a doubling in the number of publications, patents, and drugs targeting the kinome. To determine whether this was an expansion in knowledge of well-studied targets—searching in the light under the lamppost—or an explosion of investigations into previously poorly investigated targets, we searched the literature for publications on each kinase, updating Federov et al.’s assessment of the druggable kinome. The proportion of papers focusing on the 50 most-studied kinases had not changed, and the makeup of those 50 had barely changed. The majority of new drugs (80%) were against the same group of 50 kinases identified as targets 10 years ago, and the proportion of studies investigating previously poorly investigated kinases (<1%) was unchanged. With three exceptions [p38 mitogenactivated protein kinase (p38a), AMP-activated protein kinase catalytic α-subunit 1,2, and B-Raf proto-oncogene (BRAF) serine/threonine kinase], >95% of publications addressing kinases still focused on a relatively small proportion (<50%) of the human kinome independently of their involvement as cancer drivers. There is, therefore, still extensive scope for discovery of therapeutics targeting different protein kinases in cancer and still a bias toward well-characterized targets over the innovative searchlight into the unknown. Significance Statement This study presents evidence that drug discovery efforts in cancer are still to some extent focused on a narrow group of well-studied kinases 10 years after the identification of multiple novel cancer targets in the human kinome. This suggests that there is still room for researchers in academia, industry, and the not-for-profit sector to develop new and diverse therapies targeting kinases for cancer.
Optimising community health services in Australia for populations affected by stigmatised infections: What do service users want?

Abstract Stigma in health services undermines diagnosis, treatment and successful health outcomes for all communities, but especially for those affected by blood‐borne viruses and sexually transmitted infections (STIs). This study sought to examine experiences in accessing and receiving health services, including what characteristics promoted better health, safety and well‐being for people with blood‐borne viruses or STIss. It conducted 46 in‐depth interviews with people who inject drugs, gay men and other men who have sex with men, sex workers, people in custodial settings, culturally and linguistically diverse people, Indigenous Australians and young people in one Australian urban community setting. Findings reveal that stigma persists in the provision of healthcare services, and that previous experiences of discrimination or fear of mistreatment may result in a reluctance to continue to access services. On‐going staff training and education are important to ensure healthcare environments are welcoming and inclusive. Specialised services and services that employed peers were seen as favourable. Attending different services for different health needs created particular access challenges and undermined participant ability to engage in more holistic healthcare. The fragmented structure of health services was thus seen as a barrier to accessing health services, and stronger collaboration between health services is recommended.
The short‐period low‐mass binary system CC Com revisited

In this study we determined precise orbital and physical parameters of the very short-period low-mass contact binary system CC Com. The parameters are obtained by analysis of new CCD data combined with archival spectroscopic data. The physical parameters of the cool and hot components are derived as Mc = 0.717(14) M� , M h = 0.378(8) M� , Rc = 0.708(12) R� , R h = 0.530(10) R� , Lc = 0.138(12) L� ,a ndL h = 0.085(7) L� , respectively, and the distance of the system is estimated as 64(4) pc. The times of minima obtained in this study and with those published before enable us to c
Assessing the specificity of the Rosette agent DNA amplification: An optimized protocol for the detection of standard DNA among studies

In 2005, a risk of global disease emergence in freshwater fish was identified in Europe and associated with the presence of the fungallike pathogen Sphaerothecum destruens (Rosette Agent) (Combe & Gozlan, 2018; Gozlan et al., 2005). Sphaerothecum destruens is a unicellular, intracellular obligate and generalist parasite (Andreou et al., 2011; Arkush et al., 2003) that exhibits high levels of virulence (i.e. host mortality rates) in a wide variety of freshwater and marine fish species (including at least 18 cyprinids and salmonids species) in the wild and in aquaculture facilities and has been found in a wide range of climates such as the mountainous Tcheremoch River in Ukraine to the desert wadi Felrhir in Algeria (reviewed in Combe & Gozlan, 2018). For example, in 1984 S. destruens was responsible for high mortalities observed in Chinook salmon (Oncorhynchus tshawytscha) in seawater net pens in Washington state, USA (Harrell et al., 1986). Since then, it has been responsible for two mortality events of brown and rainbow trout in farms and experimental facilities in western France (Boitard et al., 2017) and the total extinction (up to 80%– 90% of mortality) of native fish populations in a catchment area in southeast Turkey (Ercan et al., 2015). Importantly, the presence of this fungallike parasite in such a variety of freshwater ecosystems is enhanced by the highly invasive nature of its healthy (i.e. asymptomatic) carrier the topmouth gudgeon, Pseudorasbora parva (reviewed in Gozlan, 2011). The intracellular and fungallike nature of S. destruens combined with low parasite loads in healthy carriers makes it extremely difficult to detect in infected hosts and therefore introduces a bias when we estimate the disease's true prevalence in a population. Furthermore, the use of slightly different primer sets to target and amplify its DNA from complex environmental matrices (e.g. water and fish tissues) results in an underestimation of its prevalence among invasive fish populations (Combe et al., 2022) and significant variations in prevalence levels between different studies (see Combe et al., 2022; Ercan et al., 2015; Gozlan et al., 2005; Spikmans et al., 2013). After 15 years of research resulting in 28 publications and despite the high risk of disease emergence worldwide associated with irreversible impacts on fish biodiversity and the economy of the aquaculture sector, the scientific community still questions the reliability, sensitivity and efficiency of 3 different PCR primer sets commonly used to detect its DNA in healthy carriers and infected native fish species. However, the first step for effective control of the emergence and spread of the rosette agent in natural ecosystems and aquaculture facilities is a highly specific and sensitive DNA detection method that allows us to estimate the true extent of infection. Here, our aim was to provide decisionmakers and
A corresponding-state approach to quark-cluster matter

The state of super-dense matter is essential for us to understand the nature of pulsars, but the non- perturbative quantum chromodynamics (QCD) makes it very difficult for direct calculations of the state of cold matter at realistic baryon number densities inside compact stars. Nevertheless, from an observational point of view, it is conjectured that pulsars could be made up of quark clusters since the strong coupling between quarks might render quarks grouped in clusters. We are trying an effort to find an equation of state of condensed quark-cluster matter in a phenomenological way. Supposing that the quark-clusters could be analogized to inert gases, we apply here the corresponding-state approach to derive the equation of state of quark-cluster matter, as was similarly demonstrated for nuclear and neutron-star matter in 1970s. According to the calculations presented, the quark-cluster stars, which are composed of quark-cluster matter, could then have high maximum mass that is consistent with observations and, in turn, further observations of pulsar mass would also put constraints to the properties of quark-cluster matter. Moreover, the melting heat during solid-liquid phase conversion and the related astrophysical consequences are also briefly discussed.
Response of Monarda citriodora L. plant to foliar spraying with extracts of moringa leaves and peels of the pomegranate

Summary Introduction: Monarda citriodora L. plant belongs to the Lamiaceae family. It is a medicinal and aromatic plant, an annual herb, one of important sources of thymol compound. This plant has various purposes such as medicinal properties, food industry, cosmetics, pharmaceuticals industry, a powerful antioxidant and antimicrobial activity. Objective: There is an ongoing need to find safe, natural sources of plant nutrients. Moringa leaves and pomegranate peels extracts are being used as a secure source of natural nutrients, and natural growth regulators on the growth and productivity of plants. Applying these bio stimulants helps avoid the excessive use of industrial materials in agriculture. So, this experiment was carried out to determine the effect of both moringa leaves extract, and pomegranate peels extract as a bio regulator on the productivity of M. citriodora plant. Methods: This experiment was carried out during two seasons (2017/2018 and 2018/2019) at the Experimental Station of Adlya Farm, Sekem Company, ElSharkia Governorate, Egypt, to study the influence of some natural extracts of moringa leaves and pomegranate peels on growth, yield as well as some chemical constituents of the dry herbs, such as total carbohydrate, total flavonoids compounds, total phenolic content, NPK content and essential oil contents and its components and determination of free radical scavenging activity of M. citriodora L. plant. Results: Both extracts of moringa leaves and pomegranate peels positively affected growth, yield, and chemical constituents compared to untreated plants. Moringa leaves extract had more effect compared with pomegranate peels extract. The main essential oil constituents were thymol, p-cymene, and carvacrol compounds. Conclusion: The application of bio-stimulants of moringa leaves extract (MLE) and pomegranate peels extract (PPE) positively affect the growth and production of M. citriodora plant.
A parametric assessment approach to solving facility‐location problems with fuzzy demands

In real‐world applications, sometimes randomness and fuzziness may coexist. In facility‐location problems, the data expressed in natural language may contain vague information. We discuss the uncertainty included in demands in facility‐location problems. The uncertain demand is called fuzzy demand in this paper. In the facility‐location model, the parameters of fuzzy demand are determined by calculating the estimated expected value of the fuzzy demand, which is obtained by using the estimated parameters of the underlying probability distribution function of the fuzzy data. Moreover, we propose a defuzzification formula of the fuzzy demand called the realization of fuzzy demand. The defuzzification formula of fuzzy demand comprises the upper bound and the lower bound of the fuzzy demand. Moreover, the error of the fuzzy demand is assessed as the mean absolute percentage error of the fuzzy demand. Empirical studies show that we can solve real‐life location problems by using the defuzzification formula of fuzzy demand and get higher profit in our facility‐location model than by using conventional methods. © 2014 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Placenta Accreta Spectrum Part II: hemostatic considerations based on an extended review of the literature

Abstract “Placenta Accreta Spectrum” (PAS) is a rare but serious pregnancy condition where the placenta abnormally adheres to the uterine wall and fails to spontaneously release after delivery. When it occurs, PAS is associated with high maternal morbidity and mortality — as PAS management can be particularly challenging. This two-part review summarizes current evidence in PAS management, identifies its most challenging aspects, and offers evidence-based recommendations to improve management strategies and PAS outcomes. The first part of this two-part review highlighted the general anesthetic approach, surgical and interventional management strategies, specialized “centers of excellence,” and multidisciplinary PAS treatment teams. The high rates of PAS morbidity and mortality are often provoked by PAS-associated coagulopathies and peripartal hemorrhage (PPH). Anesthesiologists need to be prepared for massive blood loss, transfusion, and to manage potential coagulopathies. In this second part of this two-part review, we specifically reviewed the current literature pertaining to hemostatic changes, blood loss, transfusion management, and postpartum venous thromboembolism prophylaxis in PAS patients. Taken together, the two parts of this review provide a comprehensive survey of challenging aspects in PAS management for anesthesiologists.
The Dollar Street Dataset: Images Representing the Geographic and Socioeconomic Diversity of the World

It is crucial that image datasets for computer vision are representative and contain accurate demographic information to ensure their robustness and fairness, especially for smaller subpopulations. To address this issue, we present Dollar Street—a supervised dataset that contains 38,479 images of everyday household items from homes around the world. This dataset was manually curated and fully labeled 2 , including tags for objects (e.g. “toilet,” “toothbrush,” “stove”) and demographic data such as region, country and home monthly income. This dataset includes images from homes with no internet access and incomes as low as $26.99 per month, visually capturing valuable socioeconomic diversity of traditionally under-represented populations. All images and data are licensed under CC-BY, permitting their use in academic and commercial work. Moreover, we show that this dataset can improve the performance of classification tasks for images of household items from lower income homes, addressing a critical need for datasets that combat bias.
T HE E VOLUTIONARY P SYCHOLOGY OF F ACIAL B EAUTY

■ Abstract What makes a face attractive and why do we have the preferences we do? Emergence of preferences early in development and cross-cultural agreement on attractiveness challenge a long-held view that our preferences reﬂect arbitrary standards of beauty set by cultures. Averageness, symmetry, and sexual dimorphism are good candidates for biologically based standards of beauty. A critical review and meta-analyses indicate that all three are attractive in both male and female faces and across cultures. Theorists have proposed that face preferences may be adaptations for mate choice because attractive traits signal important aspects of mate quality, such as health. Others have argued that they may simply be by-products of the way brains process information. Although often presented as alternatives, I ar-gue that both kinds of selection pressures may have shaped our perceptions of facial beauty.