Miracle-dz/UniFAR-FTUs huggingface dataset:
Primary Antibiotic Resistance of Helicobacter pylori in Different Regions of China: A Systematic Review and Meta-Analysis

Aim: Understanding the prevalence of antibiotic resistance can provide reliable information for selecting treatment options. The goal of this meta-analysis was to observe the primary antibiotic resistance of Helicobacter pylori (H. pylori) in different regions and time periods of China. Method: We searched PubMed, EMBASE, Chinese Biomedical databases and the China National Knowledge Infrastructure from inception to 20 February 2022. Data on the prevalence of H. pylori primary resistance at various time points were included. A random-effect model was established to calculate the pooled antibiotic resistance. Results: In total, 2150 articles were searched, with 70 meeting the inclusion criteria. The resistance to clarithromycin, metronidazole, levofloxacin amoxicillin, tetracycline and furazolidone in 2016–2020 were 34% (95% CI: 30–39%), 78% (95% CI: 73–84%), 35% (95% CI: 30–40%), 3% (95% CI: 1–5%), 2% (95%CI: 1–4%) and 1% (95% CI: 0–4%), respectively. Clarithromycin showed regional difference, as the resistance was higher in northern (37%, 95% CI: 32–41%) and western China (35%, 95% CI: 17–54%) than that in southern (24%, 95% CI: 17–32%) and eastern China (24%, 95% CI: 20–28%). Conclusion: The resistance of H. pylori to clarithromycin and metronidazole was high and increased over time, whereas resistance to levofloxacin, amoxicillin, tetracycline and furazolidone remained stable.
Academic Independent Director Abnormal Resignations and R&D Investment: Evidence from China

ABSTRACT We examine the effects of academic independent directors abnormal resignations on a firm’s R&D investment. We manually collect the resignations data of 3,964 academic independent directors (IDAs), and find that the abnormal resignations of IDAs reduce firms’ R&D investment. The results remain significant after employing a series of endogenous checks and robustness tests. Furthermore, we find that the lack of advising and resourcing channels caused by abnormal resignations are the primary mechanisms for the decline of the R&D investment. Our main finding is more pronounced for non-state-owned enterprises, firms with numerous independent directors, and firms with high profitability and low degrees of financial constraints. We contribute to the literature by proving that the abnormal resignations of IDAs not only decrease firms’ R&D investment but also further reduce the innovation quality and firm value over the long run. Overall, this paper supports that IDAs have positive contributions to R&D investment and firms’ value.
The Meta Distribution of Task Offloading in Stochastic Mobile Edge Computing Networks

The stochastic geometry modeling and analysis of mobile edge computing (MEC) networks contribute to the effective network configuration. Most prior works investigate the MEC network performance by spatial averaging the topological randomness, which can hide the differences among users and result in inaccurate analytical results. To address this limitation, an analytical framework is developed to study the meta distribution of the task offloading performance. We consider the Poisson MEC network where the users with dynamic task requests offload the tasks to the MEC server. Given the model, the $b$-th moment and the meta distribution of the success task offloading probability are first analyzed. Further, the exact yet convenient approximation of the MEC computing load is derived, based on which the edge computing delay is obtained. Our results demonstrate that the proposed meta-analytical framework allows tractable yet accurate analytical results, and provides additional fine-grained information about MEC-network planning.
The Role of Servicescape on Emotions and Satisfaction of Patients in Indian Hospitals

Purpose The purpose of this study is to propose and test the causal relationship among the constructs servicescape, emotions and satisfaction among users of corporate hospital services. Design/Methodology/Approach A review of literature was done, and items were adapted construct-wise from existing scales. Data were collected from 220 respondents, and the reliability and validity of the scales were tested. The relationship among the constructs was tested using structural equation modelling. Findings The model in this study postulated that (a) servicescape is positively related to satisfaction, (b) servicescape is positively related to positive emotions and negatively related to negative emotions and (c) positive emotions are positively related to patient satisfaction and negative emotions are negatively related to satisfaction. All the hypotheses were supported, and it was confirmed that servicescape has both direct and indirect relationships with satisfaction. Originality/Value The article has direct implications for healthcare service providers. Healthcare executives are encouraged to monitor the physical environment of their healthcare units. This study shows that emotions of patients play an important role in determining their satisfaction with hospital services.
The powerful, the powerless, and the empowered: Visualizations of power in high school and university through social network analysis

The investigation uses Popitz’s power theory (1992) to examine relationships among social power position, attractiveness, and verbal aggressiveness comparing social networks of high school and university students. 117 high school PE students and 195 university PE students participated in the research completing both a network and a joint non-network questionnaire. Visone 1.1 software was used for the processing of the network data and SPSS 26 was implemented for the non-network data. The results revealed in both settings that students demonstrating scientific/task attractiveness develop authoritative power/power of internalized control in their network and are protected from verbal aggressiveness and enforcement of instrumental power/power of externalized control. Social attractiveness enhances the development of authoritative power/power of internalized control in high school only. In this research, a type of powerful student is suggested who does not tend to concentrate power but rather to share power for empowering the powerless ones.
Effects of Probiotics on Growth and Immunity of Piglets

Simple Summary We evaluated effects of probiotics on growth and immune status of piglets. Body weights of probiotic-fed piglets were heavier than those of control piglets (p < 0.05). Relative populations of CD4+ and IgM+ cells isolated from the liver were increased (p < 0.05 and p < 0.01, respectively) in probiotic-fed piglets compared to control piglets. CD4+CD8+ T cells were decreased (p < 0.05) in jejunal Peyer’s patches of treated piglets. Phagocytosis of MHC class II+ cells isolated from the liver of probiotic-fed piglets was higher (p < 0.05) than that of control piglets. The probiotics have beneficial effects on the growth and health of piglets and could be good replacement for growth promoting antibiotics. Abstract Growth promoting antibiotics are used in modern animal husbandry to promote growth and avoid infections. Negative effects of these antibiotics on human health are a big concern and they need to be replaced. Probiotics are expected to be a good replacement for growth promoting antibiotics. In this study, we evaluated effects of probiotics on growth and immune status of liver and secondary lymphoid organs of piglets. Body weights of probiotic-fed piglets were heavier than those of control piglets (p < 0.05) at days 30 and 45 of the experiment. Relative populations of CD4+ and IgM+ cells isolated from the liver were significantly increased (p < 0.05 and p < 0.01, respectively) in probiotic-fed piglets compared to control piglets. CD4+CD8+ T cells were significantly decreased (p < 0.05) in jejunal Peyer’s patches of treated piglets. Phagocytosis of MHC class II+ cells isolated from the liver of probiotic-fed piglets was significantly higher (p < 0.05) than that of control piglets. Phagocytosis of granulocytes isolated from the liver and peripheral blood of probiotic-fed piglets were also higher than those of control piglets. These results indicate excellent effects on growth and immune status of piglets. In conclusion, probiotics have beneficial effects on the growth and health of piglets and could be good replacement for growth promoting antibiotics.
Deciding on the Location of the Company

The aim of this paper is to focus on a theoretical view of the issue of business localization. Business localization is the subject of research in several disciplines of the global economy. Localization is one of the most important decision-making processes in a company. It is the process of choosing a location for a specific business plan. The characteristics of the company and its surroundings are also directly related to the business plan. Dynamic resp. the rapid development of information and communication technologies opens up new business opportunities.
Nasal Microbiota, Olfactory Health, Neurological Disorders and Aging—A Review

The nasal region is one of the distinct environments for the survival of various microbiota. The human microbial niche begins to inhabit the human body right from birth, and the microbiota survive as commensals or opportunistic pathogens throughout the life of humans in their bodies in various habitats. These microbial communities help to maintain a healthy microenvironment by preventing the attack of pathogens and being involved in immune regulation. Any dysbiosis of microbiota residing in the mucosal surfaces, such as the nasal passages, guts, and genital regions, causes immune modulation and severe infections. The coexistence of microorganisms in the mucosal layers of respiratory passage, resulting in infections due to their co-abundance and interactions, and the background molecular mechanisms responsible for such interactions, need to be considered for investigation. Additional clinical evaluations can explain the interactions among the nasal microbiota, nasal dysbiosis and neurodegenerative diseases (NDs). The respiratory airways usually act as a substratum place for the microbes and can act as the base for respiratory tract infections. The microbial metabolites and the microbes can cross the blood–brain barrier and may cause NDs, such as Parkinson’s disease (PD), Alzheimer’s disease (AD), and multiple sclerosis (MS). The scientific investigations on the potential role of the nasal microbiota in olfactory functions and the relationship between their dysfunction and neurological diseases are limited. Recently, the consequences of the severe acute respiratory syndrome coronavirus (SARS-CoV-2) in patients with neurological diseases are under exploration. The crosstalk between the gut and the nasal microbiota is highly influential, because their mucosal regions are the prominent microbial niche and are connected to the olfaction, immune regulation, and homeostasis of the central nervous system. Diet is one of the major factors, which strongly influences the mucosal membranes of the airways, gut, and lung. Unhealthy diet practices cause dysbiosis in gut microbiota and the mucosal barrier. The current review summarizes the interrelationship between the nasal microbiota dysbiosis, resulting olfactory dysfunctions, and the progression of NDs during aging and the involvement of coronavirus disease 2019 in provoking the NDs.
Development of a 3D model of clinically relevant microcalcifications

A realistic 3D anthropomorphic software model of microcalcifications may serve as a useful tool to assess the performance of breast imaging applications through simulations. We present a method allowing to simulate visually realistic microcalcifications with large morphological variability. Principal component analysis (PCA) was used to analyze the shape of 281 biopsied microcalcifications imaged with a micro-CT. The PCA analysis requires the same number of shape components for each input microcalcification. Therefore, the voxel-based microcalcifications were converted to a surface mesh with same number of vertices using a marching cube algorithm. The vertices were registered using an iterative closest point algorithm and a simulated annealing algorithm. To evaluate the approach, input microcalcifications were reconstructed by progressively adding principal components. Input and reconstructed microcalcifications were visually and quantitatively compared. New microcalcifications were simulated using randomly sampled principal components determined from the PCA applied to the input microcalcifications, and their realism was appreciated through visual assessment. Preliminary results have shown that input microcalcifications can be reconstructed with high visual fidelity when using 62 principal components, representing 99.5% variance. For that condition, the average L2 norm and dice coefficient were respectively 10.5 μm and 0.93. Newly generated microcalcifications with 62 principal components were found to be visually similar, while not identical, to input microcalcifications. The proposed PCA model of microcalcification shapes allows to successfully reconstruct input microcalcifications and to generate new visually realistic microcalcifications with various morphologies.
The effect of music on weight gain of preterm infants older than 32 weeks: a randomized clinical trial

Objetivo: Evaluar el efecto de la musica grabada con estimulacion modal sobre la ganancia de peso en prematuros incluidos en el Programa Madre-Canguro. Metodos: Ensayo clinico randomizado con 61 prematuros, de ambos sexos, con edad postconcepcional superior o igual a 32 semanas, minimo de 10 dias de vida, sistema visual y auditivos sin alteraciones detectadas y hospitalizados en la Unidad Madre-Canguro. La muestra fue randomizada por sorteo en dos grupos, con 31 prematuros sometidos a la estimulacion multimodal con musica, diariamente, durante siete dias, comparados con 30 prematuros que recibieron solamente estimulacion multimodal. Se evaluaron las caracteristicas de los prematuros, ademas de ganancia de peso, consumo energetico, frecuencia cardiaca y respiratoria, senales de estres y forma de alimentacion. La comparacion entre los grupos fue realizada por las pruebas t de Student, Mann Whitney y chi-cuadrado, conforme a la naturaleza de las variables, siendo significante p<0,05. Resultados: Los grupos no mostraron diferencia significante respecto a la forma de alimentacion y al consumo energetico (p=0,46), pero la ganancia de peso fue mayor en el Grupo Experimental (p=0,002), que tambien presento la estabilidad mayor de las frecuencias cardiaca y respiratoria (p<0,01) y reduccion de las senales de estres (p=0,007) significantes respecto al Grupo Control. Conclusiones: La musica grabada asociada a la estimulacion multimodal es eficaz para mayor ganancia de peso corporal de prematuros hospitalizados y tiene influencia positiva sobre las senales vitales y de estres.
Synthetic antioxidants from a natural source can overtake the oncogenic stress management system and activate the stress-sensitized death of KSHV-infected cancer cells

Synthetic and modified natural derivatives are reported as potential bioactive compounds and are being used therapeutically against various diseases in a wide-spread manner nowadays. Cancerous cells exhibit high levels of reactive oxygen species (ROS) internally, and thus successfully manage to sustain themselves and proliferate via antioxidative mechanisms that maintain a redox balance. On this note, various antioxidants are applied as anticancer compounds, which strategically affects the ongoing oncogenic stress management system in both a pro- and antioxidative manner, resulting in cancer restriction, as well as sustaining cell proliferation via antioxidative mechanisms that promote cancer progression. Alike non-viral cancers, viral cancers exhibit varying levels of ROS during different stages of cancer progression. Hence, successful stress balance should be addressed, depending on the cancer cell stress response during the therapeutic management. The application of antioxidants is crucial and needs to be carefully designed in such cases; the respective underlying mechanisms are less understood. The role of antioxidants controlling the varied levels of stress response at different stages of Kaposi's sarcoma-associated herpes virus malignancy have not been fully reported. Therefore, the present study aimed to analyze the activity of certain antioxidants in KSHV-infected oncogenic cells. For this purpose, two naturally derived flavonoid-based antioxidants (theaflavin and novel curcumin derivatives) were selected and tested in different KSHV-infected cell lines. The findings presented herein demonstrate that these compounds can successfully induce the death of different KSHV-positive cells and can restrict the growth of KSHV-infected cell lines restricting viral reactivation by counteracting the oncogenic stress management system.
A Transactive-Based Control Scheme for Minimizing Real-Time Energy Imbalance in a Multiagent Microgrid: A CVaR-Based Model

Power systems are undergoing significant transformations due to the introduction of microgrids (MGs) and distributed energy resources (DERs). In this regard, MGs as new entities in the system facilitate the integration of independently operated DERs to the power system. In this structure, DERs would be operated by independent agents, while the microgrid's control unit (MCU) would coordinate agents’ resource scheduling to maximize social welfare. In this structure, the uncertainty of resources operated by agents could lead to real-time energy imbalance in the MG resulting in agents’ loss of profits. Consequently, a novel transactive-based-scheme is developed in this article to facilitate flexibility service exchange between the agents to minimize the real-time energy imbalance in the MG. In this context, MCU provides independent agents with bonuses as transactive signals to exploit their operational scheduling while addressing privacy concerns. The proposed framework increases the overall social welfare as well as minimizes the dependence of the MG on the upper-level system to ensure the demand–supply balance in the MG. Finally, this scheme is implemented on an MG with a multiagent structure to investigate its effectiveness in minimizing the real-time energy imbalance in the system.
Structural Insights into the NAD(P)H:Quinone Oxidoreductase from Phytophthora capsici

Soluble quinone oxidoreductases catalyze transfer of electrons from NADPH to quinones. Transfer of electrons is essential for detoxification of synthetic compounds. Here, we present the crystal structure of a NADPH-dependent QOR from Phytophthora capsici (Pc) complexed with NADPH at 2.4 Å resolution. The enzyme exhibits a bi-modular architecture, containing a NADPH-binding groove and a substrate-binding pocket in each subunit. In the crystal, each asymmetric unit of PcQOR contains two molecules stabilized by intermolecular interactions. Gel filtration and ultracentrifugation analyses reveal that it functions as a tetramer in solution. Alignment of homologous structures exhibits a conserved topology. However, the active sites vary among the homologues, indicating differences in substrate specificities. Enzymatic assays indicate that PcQOR tends to catalyze the large substrates, like 9,10-phenanthrenequinone. Computational simulation associated with site-directed mutagenesis and enzymatic activity analysis declares a potential quinone-binding channel. The ability to reduce quinones probably helps P. capsici to detoxify some harmful chemicals encountered during invasion.
Logistics Information Intelligent Platform Based on Dynamic Network Data

In order to reduce the carbon emissions of cold chain logistics and promote the construction of ecological civilization, a logistics distribution path optimization model with the minimum total cost as the objective function under the carbon tax system was proposed. The model comprehensively considers the technical advantages of the Internet of things and the characteristics of cold chain logistics; introduces soft time window, customer satisfaction, and carbon emissions as the main constraint conditions; uses the improved genetic algorithm to solve the mathematical model; uses Matlab to encode; and shows the effectiveness and rationality of the model and algorithm through examples. The experimental results show that: The total cost is 9917.12 yuan, customer satisfaction is 97.07%, carbon emission is 161.06 kg, carbon tax is 5.64 yuan/ton, fixed cost is 600 yuan, transportation cost is 72.72 yuan, refrigeration cost is 8811.73 yuan, cargo damage cost is 427.03 yuan, penalty cost is 0 yuan, The validity of the algorithm and the rationality of the model are verified. When enterprises add a carbon tax constraint, the total cost of cold chain distribution is reduced, and the carbon emission is reduced compared with that without carbon tax. The research can provide a reference for enterprise cold chain logistics distribution decisions.
A 40.68-MHz Active Rectifier Using an Inverter-Based Conduction-Time Generator for Wirelessly Powered Implantable Medical Devices

This brief presents a 40.68-MHz active rectifier with a near-zero-quiescent-current inverter-based conduction-time generator for wirelessly powered implantable devices. By using the proposed scheme, the rectifier achieves near-optimum switching operation with negligible turn-on and -off delays and thus high power conversion efficiency even at very high frequency such as 40.68 MHz. The active rectifier was fabricated in a standard 0.18 <inline-formula> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula> CMOS process. With a 500-<inline-formula> <tex-math notation="LaTeX">${\Omega }$ </tex-math></inline-formula> load resistor, the measured power conversion efficiency is higher than 87% through the whole input range of 1.2 V to 1.8 V, and a peak efficiency of 93.3% is achieved with 1.2 V input amplitude.
Training Socially Engaging Robots: Modeling Backchannel Behaviors with Batch Reinforcement Learning

A key aspect of social human-robot interaction is natural non-verbal communication. In this work, we train an agent with batch reinforcement learning to generate nods and smiles as backchannels in order to increase the naturalness of the interaction and to engage humans. We introduce the Sequential Random Deep Q-Network (SRDQN) method to learn a policy for backchannel generation, that explicitly maximizes user engagement. The proposed SRDQN method outperforms the existing vanilla Q-learning methods when evaluated using off-policy policy evaluation techniques. Furthermore, to verify the effectiveness of SRDQN, a human-robot experiment has been designed and conducted with an expressive 3d robot head. The experiment is based on a story-shaping game designed to create an interactive social activity with the robot. The engagement of the participants during the interaction is computed from user's social signals like backchannels, mutual gaze and adjacency pair. The subjective feedback from participants and the engagement values strongly indicate that our framework is a step forward towards the autonomous learning of a socially acceptable backchanneling behavior.