Miracle-dz/UniFAR-FTUs huggingface dataset:
Plasmoids in the Jovian Magnetotail: Statistical Survey of Ion Acceleration Using Juno Observations

Transient magnetic reconnection plays an important role in energetic particle acceleration in planetary magnetospheres. Jupiter's magnetosphere provides a unique natural laboratory to study processes of energy transport and transformation. Strong electric fields in spatially confined structures such as plasmoids can be responsible for ion acceleration to high energies. In this study we focus on the effectiveness of ion energization and acceleration in plasmoids. Therefore, we present a statistical study of plasmoid structures in the predawn magnetotail, which were identified in the magnetometer data of the Juno spacecraft from 2016 to 2018. We additionally use the energetic particle observations from the Jupiter Energetic Particle Detector Instrument which discriminates between different ion species. We are particularly interested in the analysis of the acceleration and energization of oxygen, sulfur, helium, and hydrogen ions. We investigate how the event properties, such as the radial distance and the local time of the observed plasmoids in the magnetotail, affect the ion intensities close to the current sheet center. Furthermore, we analyze if ion acceleration is influenced by magnetic field turbulence inside the plasmoids. We find significant heavy ion acceleration in plasmoids close to the current sheet center which is in line with the previous statistical results based on Galileo observations conducted by Kronberg et al. (2019, https://doi.org/10.1029/2019JA026553). The observed effectiveness of the acceleration is dependent on the position of Juno in the magnetotail during the plasmoid event observation. Our results show no correlation between magnetic field turbulence and nonadiabatic acceleration for heavy ions during plasmoids.
Unraveling Membrane Perturbations Caused by the Bacterial Riboregulator Hfq

Hfq is a pleiotropic regulator that mediates several aspects of bacterial RNA metabolism. The protein notably regulates translation efficiency and RNA decay in Gram-negative bacteria, usually via its interaction with small regulatory RNAs. Previously, we showed that the Hfq C-terminal region forms an amyloid-like structure and that these fibrils interact with membranes. The immediate consequence of this interaction is a disruption of the membrane, but the effect on Hfq structure was unknown. To investigate details of the mechanism of interaction, the present work uses different in vitro biophysical approaches. We show that the Hfq C-terminal region influences membrane integrity and, conversely, that the membrane specifically affects the amyloid assembly. The reported effect of this bacterial master regulator on membrane integrity is discussed in light of the possible consequence on small regulatory RNA-based regulation.
Multi‐Decadal Simulation of Marsh Topography Under Sea Level Rise and Episodic Sediment Loads

Coastal marsh within Mediterranean climate zones is exposed to episodic watershed runoff and sediment loads that occur during storm events. Simulating future marsh accretion under sea level rise calls for attention to: (a) physical processes acting over the time scale of storm events and (b) biophysical processes acting over time scales longer than storm events. Using the upper Newport Bay in Southern California as a case study, we examine the influence of event‐scale processes on simulated change in marsh topography by comparing: (a) a biophysical model that integrates with an annual time step and neglects event‐scale processes (BP‐Annual), (b) a physical model that resolves event‐scale processes but neglects biophysical interactions (P‐Event), and (c) a biophysical model that resolves event‐scale physical processes and biophysical processes at annual and longer time scales (BP‐Event). A calibrated BP‐Event model shows that large (>20‐year return period) episodic storm events are major drivers of marsh accretion, depositing up to 30 cm of sediment in one event. Greater deposition is predicted near fluvial sources and tidal channels and less on marshes further from fluvial sources and tidal channels. In contrast, the BP‐Annual model poorly resolves spatial structure in marsh accretion as a consequence of neglecting event‐scale processes. Furthermore, the P‐Event model significantly overestimates marsh accretion as a consequence of neglecting marsh surface compaction driven by annual scale biophysical processes. Differences between BP‐Event and BP‐Annual models translate up to 20 cm per century in marsh surface elevation.
Species prevalence, antimicrobial susceptibility of enterococci isolated from various clinical samples in tertiary care hospital

Introduction: Emergence of multidrug resistant nosocomial enterococcus strains emphasizes the need for further investigating enterococci. Objectives: To characterize enterococci from various clinical specimens, to determine the antimicrobial susceptibility pattern and to explore the association between virulence factors and antimicrobial resistance. Material and Methods: Two hundred and eighty three clinical isolates of enterococcus were speciated and subjected to antimicrobial susceptibility testing using Kirby Bauer disc diffusion method. They were screened for vancomycin resistance by vancomycin screening agar method as recommended by Clinical Laboratory Standards Institute 2020, and confirmed by determination of minimum inhibitory concentration using agar dilution and E test. Genotypic confirmation was done by polymerase chain reaction. Results: Of the 283 enterococci isolated, 12 species were identified; predominant species was Enterococcus faecalis (82.33%). High level gentamicin resistance (HLGR) and vancomycin resistance were observed among 55.57% and 6.01% of Enterococcus isolates respectively. All vancomycin resistant enterococci (VRE) were Enterococcus faecalis and had vanA phenotype and genotype. Sensitivity to linezolid was 100 per cent among enterococci. Conclusion: Our study reveals the occurrence of sizable number of HLGR isolates and emergence of VRE.
Association between Parkinson’s Disease and Psychosocial Factors: Results of the Nationally Representative German Ageing Survey

Objective: The aim of this study was to clarify the link between Parkinson’s disease (i.e., comparing individuals with Parkinson’s disease and individuals without Parkinson’s disease) and psychosocial outcomes (in terms of life satisfaction, optimism, loneliness, perceived social isolation and perceived autonomy). Methods: Cross-sectional data (wave 5) were used from the nationally representative German Ageing Survey (with n = 7832). Life satisfaction was quantified using the Satisfaction with Life Scale. Optimism was measured using the Brandstädter and Wentura tool. Perceived autonomy was quantified using the Schwarzer tool. Loneliness was quantified using the De Jong Gierveld tool. Perceived social isolation was quantified using the Bude and Lantermann tool. Physician-diagnosed Parkinson’s disease served as the key independent variable. Results: Multiple linear regressions showed that individuals with Parkinson’s disease reported significantly lower perceived autonomy (β = −0.30, p < 0.01) compared to individuals without Parkinson’s disease. In contrast, they did not report worse psychosocial outcomes (in terms of life satisfaction, optimism, loneliness and perceived social isolation). Conclusion: Study findings showed a quite strong association between Parkinson’s disease and perceived autonomy. Future research could elucidate the underlying mechanisms.
PENGENALAN WEB DESAIN KEPADA SANTRI RAHMATAN LIL’ALAMIN INTERNATIONAL ISLAMIC BOARDING (RLA IIBS) ARIPAN KABUPATEN SOLOK

Pemanfaatan komputer saat ini cukup beragam mulai sebagai alat bantu dalam menyelesaikan suatu pekerjaan sampai mengolah data hasil penelitian maupun untuk mengoperasikan program-program penyelesaian problem-problem ilmiah, industri dan bisinis. Seperti misalnya website yang digunakan untuk melihat informasi serta memberikan kemudahan dalam mengerjakan suatu pekerjaan. Pada zaman sekarang ini hampir semua kantor sudah memanfaatkan komputer dalam menunjang pekerjaan, tetapi masih sangat banyak yang belum tau bagaimana cara memanfaatkan teknologi komputer tersebut dengan benar dan maksimal. Oleh karena ini pada objek pengabdian masyarakat yang akan dilakukan adalah bertujuan untuk memberikan pengtahuan teknologi komputer khususnya web desain untuk memberikan pengetahuan kepada Santri RLA IIBS Aripan Kab. Solok. Di dalam laporan ini akan dipaparkan mengenai kegiatan pengabdian kepada masyarakat khususnya di Rahmatan Lil Alamin Boarding School (RLA-IIBS) dalam rangka memberikan pengarahan kepada siswa mengenai Pengenalan web desain sehingga proses pembelajaran akan lebih menarik dan materi yang disampaikan guru akan lebih mudah diterima oleh santri.
Simultaneous Determination of Ceftazidime and Avibactam in Human Plasma and Cerebrospinal Fluid by High-Performance Liquid Chromatography – Tandem Mass Spectrometry (HPLC-MS/MS)

Abstract A method is reported for the simultaneous determination of ceftazidime and avibactam in human plasma and cerebrospinal fluid utilizing high-performance liquid chromatography – tandem mass spectrometry (HPLC-MS/MS). The validated method was used to monitor the drugs in the treatment of central nervous system infections. The analytes were extracted from plasma and cerebrospinal fluid by simple protein precipitation using acetonitrile. A reversed-phase HSS T3 column (5.0 μm, 4.6 × 100 mm, Waters) was employed for the separation with a total analysis time of 5 minutes. Ceftazidime and avibactam eluted in 2.15 min and 2.87 min, respectively. The acquisition was separated into two periods to allow analysis in different ionization modes. A multi-reaction monitoring analysis was performed with the transition m/z 547.2–468.1 for ceftazidime, and m/z 552.3–468.1 for ceftazidime-d5 (positive mode), m/z 263.9–96.1 for avibactam, and m/z 136.8–92.8 for salicylic acid (negative mode). The plasma calibration curves of the analytes displayed good linearity across the range from 1 to 100 μg/mL for ceftazidime and 0.1–20 μg/mL for avibactam. Calibration curves for cerebrospinal fluid assay were established from 0.4 to 16 μg/mL (ceftazidime) and 0.2–8 μg/mL (avibactam). The accuracy was between 89.5% and 108.5%. The within- and between-batch precisions with the relative standard deviation were lower than 15%. The developed method had no observed matrix effects. The analytes were stable during the analytical and sample processing. The developed and validated method was successfully applied in routine clinical practice and helps to assess the adequacy of therapy and ensure sufficient ceftazidime and avibactam levels in central nervous system infections.
Effect Of Use Of Flexible Transfemoral Prosthesis On Level Of Independence In Performing Daily Activities Of Transfemoral Amputee

Background: Transfemoral amputees experience many difficulties in carrying out daily activities. One of the devices that can be used in above-knee amputation patients is transfemoral prosthesis. The use of transfemoral prostheses in post-amputation patients can help with activities, one of which is independence in self-care, mobility, and locomotion. Methods: The study was conducted at PT Kuspito Orthotic Prosthetics and the time of the study was carried out in 2021. The population of this study was users of flexible prostheses at PT Kuspito Ortotik Prosthetic. The samples of this study were flexible prostheses users at PT. Kuspito prosthetic orthotic that meets the criteria as many as 30 users. The sampling technique was purposive sampling, inclusion criteria: subjects aged 17-35 years, subjects in good health, subjects using a flexible unilateral prosthesis, at least using an artificial leg for 1 month, having a strength value of 4, having normal Range Of Motion. Exclusion criteria: the subject had advanced disease, bilateral prosthesis user. The measuring instrument used was the Functional Independence Measure (FIM) questionnaire that is valid and reliable. Results: The value of Sig. is 0.000, there is a significant difference in the level of independence between the results of the pre-test and post-test. there is a significant difference in the results that using a flexible prosthesis can increase the level of independence in above-knee amputees in carrying out daily activities. Conclusion: The functional independence of above-knee amputation patients is strongly influenced by the use of a flexible prosthesis. It is recommended that above-knee amputation patients can use a flexible prosthesis to increase the level of independence.
Evaluation of Mental Stress using Different Physiological Parameters: A Review

Mental Stress plays a vital role in everyday life. It is mental state and is accompanied by physiological changes. So monitoring of these significant changes is important, which can help to identify the matter of anxiety at an early stage before some serious health problem. Continuous stress monitoring may help users better understand their stress patterns and provide physicians with more reliable data for interventions. The basic parameters on which stress can be identified are heart rate, galvanic skin response, body temperature; blood pressure etc. combinations of different parameters provide more accurate results. Usage of multiple parameters aids in better determination of stress. Combination of different parameters like galvanic skin response and blood pressure, electrocardiogram, skin temperature and heart rate are used.
An observational study on the onset of the summer monsoon over South China around Hong Kong

This paper presents a study of the physical processes responsible for the summer monsoon onset over South China, which is defined using the rainfall data over Hong Kong. Four sets of meteorological parameters are examined: 1) mean-sea-level pressure; 2) surface and upper-level winds; 3) surface and the 850 hPa temperatures; and 4) blackbody temperature (T bb ). The first three sets are from the gridded analyses of the European Centre for Medium-Range Weather Forecasts (ECMWF) for the period 1985-1990 while the T bb data are from the Geostationary Meteorological Satellite-4 (GMS-4). Daily values of each parameter for the six years are then composited each day for the period ten days before to after the onset day. The results of the composite study suggest the following sequence of events. Ten days before the onset, a north-south temperature gradient between South China (SC) and northern Australia is first established as the temperature over the latter decreases. This temperature gradient is further enhanced as time goes on when the temperatures over SC and South China Sea (SCS) increase. Development of a surface low over Beibu Wan (around 107°E 18°N) is also observed four days before onset. This surface low deepens throughout the onset period. The enhanced temperature gradient and the deepening of the low apparently lead to an eastward shift of the cross-equatorial flow originally present around 60°-80°E. Together with another branch of this flow within 90° to 110°E, the low-level southerly winds over the SCS are therefore enhanced. This results in an increase in low-level convergence in the region of 100°-120°E, 15°-25°N which leads to enhanced rising motion. This is indicated by the enlargement of the 200-hPa anticyclone on Day(0). The northerlies on the eastern flank of this anticyclone then form a prominent return flow towards the equator. A monsoon trough is thus established along the SC coast and convection activity increases, as indicated by the T bb data. This represents the onset of the summer monsoon over South China.
Midwives’ ethical practice in selected labour units in Tshwane, Gauteng Province, South Africa

Background. Midwives provide the majority of maternal and child healthcare in South Africa (SA). The care provided by midwives during childbirth is a unique life experience for women, and in order to provide safe care, midwives are expected to comply with ethical principles, policies and legislation governing their profession, as guided by the International Confederation of Midwives. Objective. To establish midwives’ perception of ethical and professional practice in selected labour units of public healthcare, in Tshwane District, Gauteng Province, SA. Methods. A qualitative, exploratory, descriptive cross-sectional design was applied by use of in-depth interviews. Non-probability purposive sampling was used to draw a sample from midwives with 2 or more years of experience working in the labour units. Data saturation was reached with the eighth participant. The digitally recorded interviews were transcribed verbatim. Data analysis was based on interpretive description. Results. The findings revealed that midwives do understand the ethical code of conduct. They experience challenges such as staff shortages, non-compliance with policies and lack of managerial support, which compromise ethical conduct to a certain extent. Conclusion. It is hoped that the suggested administrative, midwifery practice and research recommendations will guide the process of empowering midwives in ethical practice.
A Simulation Analysis and Screening of Deleterious Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) in Sheep LEP Gene

Leptin is a polypeptide hormone produced in the adipose tissue and governs many processes in the body. Recently, polymorphisms in the LEP gene revealed a significant change in body weight regulation, energy balance, food intake, and reproductive hormone secretion. This study considers its crucial role in the regulation of the economically important traits of sheep. Several computational tools, including SIFT, Predict SNP2, SNAP2, and PROVEAN, have been used to screen out the deleterious nsSNPs. Following the screening of 11 nsSNPs in the sheep genome, 5 nsSNPs, T86M (C → T), D98N (G → A), N136T (A → C), R142Q (G → A), and P157Q (C → A), were predicted to have a significant deleterious effect on the LEP protein function, leading to phenotypic difference. The analysis of proteins' stability change due to amino acid substitution using the I-stable, SDM, and DynaMut consistently confirmed that three nsSNPs (T86M (C → T), D98N (G → A), and P157Q (C → A)) increased protein stability. It is suggested that these three nsSNPs may enhance the evolvability of LEP protein, which is vital for the evolutionary adaptation of sheep. Our findings demonstrate that the five nsSNPs reported in this study might be responsible for sheep's structural and functional modifications of LEP protein. This is the first comprehensive report on the sheep LEP gene. It narrow downs the candidate nsSNPs for in vitro experiments to facilitate the development of reliable molecular markers for associated traits.
Combining Multi-objective Evolutionary Approach and Machine Learning to Optimize PCI Configuration in Large-scale LTE Networks

Wireless interference seriously affects the quality of service in mobile communication networks, and PCI planning and optimization is an effective method to reduce interference in 4G and 5G networks. Most of the existing PCI configuration optimization methods focus on solving basic problems, such as PCI collision, PCI confusion and PCI mod 3 interference, which can not meet the complex requirements of actual LTE network optimization. In this paper, we establish six objectives and six constraints based on the PCI optimization requirements of large-scale real LTE networks, and propose a decomposition-based multi-objective evolutionary algorithm combining community detection and reinforcement learning mechanism improvement. Specifically, community detection is used to improve the selection method of crossover segments and mutation points in the evolutionary algorithm so that good sub-region patterns can be inherited to the next generation, and Q-learning method is took to adaptively adjust the crossover and mutation probabilities according to the evolutionary iteration number, population diversity and average fitness to improve the diversity of the population. The PCI optimization results for 1231 optimized cells and 5169 associated cells in a city of China show that our algorithm has improvement in all six objectives with an average 1.38% increase in the optimization rate of the original solution compared to the baseline algorithm, and 21 % reduction in runtime for 1000 generations. Therefore, the proposed algorithm is an effective method to improve PCI configuration and reduce network interference.
Predictive Value of Adenoviral Load for Bronchial Mucus Plugs Formation in Children with Adenovirus Pneumonia

Background The study aimed to explore risk factors for bronchial mucus plugs (BMP) formation in children with adenovirus (AdV) pneumonia. Methods A retrospective study was conducted on children with AdV pneumonia who underwent bronchoscopy from January 2019 to December 2019. Children were divided into the BMP group and the control group, depending on whether BMP was formed or not. The clinical information and treatment proposals of the two groups of children were counted and analyzed via multiple logistic regression analysis, ROC curve analysis, and correlation analysis. Results Among 453 patients with AdV pneumonia, 185 (40.84%) were in the BMP group. Among all the cases, there were 188 patients with a single AdV infection, including 64 (34.04%) in the BMP group and 124 (65.96%) in the control group. The incidence of dyspnea, poor spirits, mixed infections, and other symptoms in the BMP group was higher than in the control group. Children in the BMP group had a longer heat range. C-reactive protein (CRP), lactate dehydrogenase (LDH), D-dimer (DD), and AdV load levels were higher in the MBP group. AdV load, Mycoplasma coinfection, DD, heat range, and LDH were independent risk factors for BMP, among which AdV load was the most significant (AUC = 0.819). AdV load was positively correlated with other risk factors, respectively. AdV load and heat range were independent risk factors for BMP patients with a single AdV infection. Conclusion AdV load might have important clinical value in predicting BMP development in AdV pneumonia.
Principles of assessment in school-based making

ABSTRACT While school educators are increasingly interested in adopting maker pedagogy, many schools struggle to integrate making with their existing core curriculum because of the difficulty in assessing the learning that occurs in maker classrooms. To address this issue, we collaborated with educators on design-based research focused on assessment in maker classrooms. We investigated assessment approaches that support the process of making. This paper reports on four design principles of assessment in school-based making that emerged from a literature review and the collaborative development process with educators. We discuss the challenges and opportunities for assessment in maker classrooms, as well as strategies to seamlessly embed assessment within a classroom’s culture, norms, and activities.
Using inverse learning for controlling bionic robotic fish with SMA actuators

In this study, we develop an untethered bionic soft robotic fish for swimming motion. The body of the fish is molded using soft silicone rubber, and we utilize shape memory alloy wires for its actuators. Its lightness and flexibility allow the robotic fish to generate biomimetic swimming motions. Due to the complexity of mathematically modeling the robot’s swimming dynamics, building a realistic simulator is prohibitively difficult. Hence, in this study, we introduce inverse learning for a feedforward neural network to generate control parameters for realizing desired swimming motions and subsequently utilize the neural network for real-time control. In this paper, we report on the electro-mechanical structure of our robotic fish and the experiment of the neuro-controller. Graphical abstract