Miracle-dz/UniFAR-FTUs huggingface dataset:
Long term follow-up and outcomes of re-treatment in an expanded 50 patient single-center phase II prospective trial of Lutetium-177 ( 177 Lu) PSMA-617 theranostics in metastatic castrate-resistant prostate cancer

Objectives: Lutetium-177 ( 177 Lu)-PSMA-617 (LuPSMA) is a radioligand with high affinity for prostate specific membrane antigen (PSMA) enabling targeted beta-irradiation of prostate cancer. We have previously reported favorable activity with low toxicity in a prospective phase II trial involving 30 men with metastatic castrate-resistant prostate cancer (mCRPC). We now report their longer-term outcomes including a 20 patient extension cohort and outcomes of subsequent systemic treatments following completion of trial therapy. Methods: 50 patients with PSMA-avid mCRPC who had progressed after standard therapies received up to 4 cycles of LuPSMA every 6 weeks. Endpoints included PSA response (PCWG2), toxicity (CTCAE v4.03), imaging response, patient-reported health-related quality of life (QoL), progression-free and overall survival. We also describe, as a novel finding, outcomes of men who subsequently progressed and had further systemic therapies, including LuPSMA. Results: 75 men were screened to identify 50 patients eligible for treatment. Adverse prognostic features of the cohort included short median PSA doubling time (2.3 months) and extensive prior treatment including prior docetaxel (84%), cabazitaxel (48%), and abiraterone and/or enzalutamide (92%). The mean administered radioactivity was 7.5 GBq/cycle. PSA decline ≥ 50% was achieved in 32 of 50 patients (64%, 95% CI 50-77%), including 22 patients (44%, 95% CI 30-59%) with ≥ 80% decrease. Of 27 patients with measurable soft tissue disease, 15 (56%) achieved an objective response by RECIST 1.1. The most common toxicities attributed to LuPSMA were self-limiting G1-2 dry mouth (66%), transient G1-2 nausea (48%), G3-4 thrombocytopenia (10%) and G3 anemia (10%). Brief pain inventory severity and interference scores decreased at all time points including at the 3 month follow-up with a decrease of -1.2 (95% CI -0.5 to -1.9, p=0.001) therapy. Upon progression, re-challenge LuPSMA demonstrated higher response rates than other systemic therapies.
COPD_A_298514 1193..1201

1Tartu University Hospital, Lung Clinic, Tartu, Estonia; 2Medical Affairs, Orion Corporation, Espoo, Finland; 3Research Unit of Pulmonary Diseases, Helsinki University Hospital and Helsinki University, Helsinki, Finland; 4Inhalation Platform, Orion Corporation, Espoo, Finland; 5Biostatistics and Data Analytics, Orion Corporation, Espoo, Finland Introduction: Achieving correct inhalation technique through an inhaler to ensure effective drug delivery is key to managing symptoms in patients with chronic obstructive pulmonary disease (COPD). However, many patients struggle to use their inhalers correctly, with the resultant reduction in therapeutic benefit. Consequently, appropriate inhaler choice is important to maximize clinical benefit. The primary objective of this study was to characterize inspiratory flow parameters across two Easyhaler inhalers and the HandiHaler inhaler in patients with COPD and healthy volunteers. Methods: In this randomized, open-label, crossover study, subjects (100 patients with COPD; 100 healthy volunteers) were trained to perform inhalations of placebo powder via two variants of Easyhaler and placebo capsules via the HandiHaler inhalers. Subjects then performed three placebo inhalations through each inhaler in a random sequence. Inspiratory flow parameters were assessed, including peak inspiratory flow (PIF), for each inhaler. A parallel sub-study was conducted in patients with COPD from the main study to assess correct use of the inhalers, patient’s preference, ability to learn to use the inhalers, and the feasibility of the In-Check Dial device to measure PIF values. Results: Mean PIF rates and inspiratory volumes through the three inhalers were similar between patients with COPD and healthy volunteers, and all subjects achieved the 30 L/min PIF required for effective use of Easyhaler. Almost 70% of the 88 patients enrolled in the sub-study used the Easyhaler and HandiHaler inhalers without errors. The Easyhaler was preferred by 51% of patients, while 25% favored the HandiHaler. Teaching the use of both inhalers to almost 70% of patients was very easy. The In-Check Dial PIF values and those obtained via spirometry were strongly correlated (p<0.0001) for all three inhalers. Conclusion: The respiratory performance of patients with COPD does not appear to be a limiting factor in the use of Easyhaler.
OPT3 Is a Component of the Iron-Signaling Network between Leaves and Roots and Misregulation of OPT3 Leads to an Over-Accumulation of Cadmium in Seeds

Plants and seeds are the main dietary sources of zinc, iron, manganese, and copper, but are also the main entry point for toxic elements such as cadmium into the food chain. We report here that an Arabidopsis oligopeptide transporter mutant, opt3-2, over-accumulates cadmium (Cd) in seeds and roots but, unexpectedly, under-accumulates Cd in leaves. The cadmium distribution in opt3-2 differs from iron, zinc, and manganese, suggesting a metal-specific mechanism for metal partitioning within the plant. The opt3-2 mutant constitutively up-regulates the Fe/Zn/Cd transporter IRT1 and FRO2 in roots, indicative of an iron-deficiency response. No genetic mutants that impair the shoot-to-root signaling of iron status in leaves have been identified. Interestingly, shoot-specific expression of OPT3 rescues the Cd sensitivity and complements the aberrant expression of IRT1 in opt3-2 roots, suggesting that OPT3 is required to relay the iron status from leaves to roots. OPT3 expression was found in the vasculature with preferential expression in the phloem at the plasma membrane. Using radioisotope experiments, we found that mobilization of Fe from leaves is severely affected in opt3-2, suggesting that Fe mobilization out of leaves is required for proper trace-metal homeostasis. When expressed in yeast, OPT3 does not localize to the plasma membrane, precluding the identification of the OPT3 substrate. Our in planta results show that OPT3 is important for leaf phloem-loading of iron and plays a key role regulating Fe, Zn, and Cd distribution within the plant. Furthermore, ferric chelate reductase activity analyses provide evidence that iron is not the sole signal transferred from leaves to roots in leaf iron status signaling.
Cross-modal associations and synaesthesia

We report associations between vowel sounds, graphemes, and colors collected online from over 1,000 Dutch speakers. We also provide openmaterials, including a Python implementation of the structuremeasure and code for a single-pageweb application to run simple cross-modal tasks. We also provide a full dataset of color–vowel associations from 1,164 participants, including over 200 synesthetes identified using consistencymeasures. Our analysis reveals salient patterns in the cross-modal associations and introduces a novel measure of isomorphism in cross-modal mappings. We found that, while the acoustic features of vowels significantly predict certain mappings (replicating prior work), both vowel phoneme category and grapheme category are even better predictors of color choice. Phoneme category is the best predictor of color choice overall, pointing to the importance of phonological representations in addition to acoustic cues. Generally, high/front vowels are lighter, more green, and more yellow than low/back vowels. Synesthetes respond more strongly on some dimensions, choosing lighter and more yellow colors for high and mid front vowels than do nonsynesthetes.We also present a novel measure of cross-modal mappings adapted from ecology, which uses a simulated distribution of mappings to measure the extent to which participants’ actual mappings are structured isomorphically across modalities. Synesthetes have mappings that tend to be more structured than nonsynesthetes’, and more consistent color choices across trials correlate with higher structure scores. Nevertheless, the large majority (~ 70%) of participants produce structured mappings, indicating that the capacity to make isomorphically structured mappings across distinct modalities is shared to a large extent, even if the exact nature of the mappings varies across individuals. Overall, this novel structure measure suggests a distribution of structured cross-modal association in the population, with synesthetes at one extreme and participants with unstructured associations at the other.
University of Birmingham Permissive Controller Synthesis for Probabilistic Systems

We propose novel controller synthesis techniques for probabilistic systems modelled using stochastic two-player games: one player acts as a controller, the second represents its environment, and probability is used to capture uncertainty arising due to, for example, unreliable sensors or faulty system components. Our aim is to generate robust controllers that are resilient to unexpected system changes at runtime, and ﬂexible enough to be adapted if additional constraints need to be imposed. We develop a permissive controller synthesis framework, which generates multi-strategies for the controller, oﬀering a choice of control actions to take at each time step. We formalise the notion of permissivity using penalties, which are incurred each time a possible control action is disallowed by a multi-strategy. Permissive controller synthesis aims to generate a multi-strategy that minimises these penalties, whilst guaranteeing the satisfaction of a speciﬁed system property. We establish several key results about the optimality of multi-strategies and the complexity of synthesising them. Then, we develop methods to perform permissive controller synthesis using mixed integer linear programming and illustrate their eﬀectiveness on a selection of case studies.
Testing the Environmental Kuznets Curve Hypothesis for Turkey: The Role of Clean Energy Consumption and Ecological Footprint

This study aims to investigate the dynamic relationship between income, clean energy consumption, exports, imports, urbanization and ecological footprint for Turkey from 1973 to 2015 using the environmental Kuznets curve hypothesis. The long-term coefficients derived from the ARDL approach demonstrate that import increase the ecological footprint, whereas urbanization and clean energy consumption do not have an impact on environmental pollution in the long-term. In addition, the 2001 dummy variable is negative and statistically significant. The crisis in 2001 slowed down the economic growth rate. This situation also caused reduction of environmental pollution. Moreover, the long run estimates indicate that the EKC hypothesis is valid in Turkey. However, the turning point of per capita income was calculated as $16,045 that outside of the analyzed period. As economic activities increase, human pressure on nature continues to increase. Consequently, the only factor that reduces the ecological footprint has been determined as exports. In contrast, economic growth and clean energy consumption cannot be used as a tool to reduce the ecological footprint. Turkey needs a higher level of per capita income than the threshold level to improve environmental quality.
Running Title : Holistic recollection involves subfield CA 3 2

eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse This article is distributed under the terms of the Creative Commons Attribution (CC BY) licence. This licence allows you to distribute, remix, tweak, and build upon the work, even commercially, as long as you credit the authors for the original work. More information and the full terms of the licence here: https://creativecommons.org/licenses/
Modeling and Analysis of Different Chevron Nozzle for Noise Reduction

The purpose of making this project is to reduce the very harmful noise produce by the commercial aircrafts. The most of noise of aircraft is only produce by the aircraft engines. In commercial aircraft usually Turbo-fan use as gas turbine engine for producing thrust. In turbo-fan engines mostly uses convergent type nozzle. Chevron convergent Nozzle in currently very useful as a noise prevent nozzle for passenger aircrafts. The main noise produce sources arise in the Fan or Compressor, Turbine, nozzle and the exhaust jet (jet flows) in jet engine. Jet exhaust noise is created by the disturbance occur in turbulent mixing of the exhaust gases with the surrounding and its effected by the shearing action caused by the relative velocity between the jet exhaust and the surrounding. There are many attempt is made to understand the effect of various geometric parameters (design) of a chevron nozzle and similar like on noise prevention. This project shows the acoustics effects on chevron nozzle with various changes in geometry like including different number of chevrons tooth & changing the shapes of tooths also giving the appropriate nozzle among that which have nice output compare to others.
A bilateral control scheme for vehicle steer-by-wire system with road feel and steering controller design

Steer-by-wire (SBW) system replaces the mechanical linkages in a conventional steering system with electronic actuators. However, such a steering system has problems regarding how to harmonize angle and torque close loop control strategy whilst guaranteeing SBW system stability. Towards this problem, a bilateral control scheme is proposed for SBW system with steering and road feel feedback control. A new torque and angle feedback deviation type bilateral control scheme is designed based on the analysis of several typical bilateral control schemes. In this bilateral control scheme, it only needs to measure steering wheel angle, steering wheel torque, pinion angle and steering motor torque, whilst it does not need to estimate tire and road force, neither to deploy complicated and expensive sensors or devices. The Llewellyn stability criterion and wave variable control are used to analyze the influencing factors of the stability of the SBW system and to control the stability respectively. The transparency of the SBW system is analyzed based on the impedance theory. In order to improve vehicle handling, the road feel feedback torque is designed by using a compensation controller. The bilateral control scheme and compensation controllers are implemented and their performance is experimentally validated using test vehicle. Test results demonstrate the efficiency and effect of the proposed algorithm.
International tourism, growth and environmental quality: the case of three North African countries

This paper examines the interactive relationships between international tourism, economic growth and environmental quality in three countries of North Africa (Tunisia, Maroc, Egypt) over the period 1981 -2019. The study used the ARDL model. The results show that tourism has a direct and statistically significant impact on the level of carbon dioxide) emissions (CO2) and economic growth in the long run. The results also confirm the existence of an inverted U-shaped relationship for Morocco and Egypt between CO2 emissions and income level, while this relationship takes the form of a Ushaped in Tunisia. The error correction models in this study have shown that: (1) CO2 emissions converge towards their long-term equilibrium situation with a speed of the order of 5.8% in Morocco, 20% in Egypt and 27.9% in Tunisia through economic growth channels, of the consumption of energy and tourism. This finding reveals that the growth of tourism allows significantly, climate change to move to higher levels. (2) economic growth converges towards its long-term equilibrium by an adjustment speed of the order of 25.7% in Morocco, 5.8% in Egypt and 2.1% in Tunisia.
Carbon Debt Payback Time for a Biomass Fired CHP Plant—A Case Study from Northern Europe

The European Union (EU) has experienced a large increase in the use of biomass for energy in the last decades. In 2015, biomass used to generate electricity, heat, and to a limited extent, liquid fuels accounted for 51% of the EU’s renewable energy production. Bioenergy use is expected to grow substantially to meet energy and climate targets for 2020 and beyond. This development has resulted in analyses suggesting the increased use of biomass for energy might initially lead to increased greenhouse gas (GHG) emissions to the atmosphere, a so-called carbon debt. Here, we analyze carbon debt and payback time of substituting coal with forest residues for combined heat and power generation (CHP). The analysis is, in contrast to most other studies, based on empirical data from a retrofit of a CHP plant in northern Europe. The results corroborate findings of a carbon debt, here 4.4 kg CO2eq GJ−1. The carbon debt has a payback time of one year after conversion, and furthermore, the results show that GHG emissions are reduced to 50% relative to continued coal combustion after about 12 years. The findings support the use of residue biomass for energy as an effective means for climate change mitigation.
A STUDY OF CHANGES TO SPECIFIC ABSORBTION RATES IN THE HUMAN EYE CLOSE TO PERFECTLY CONDUCTING SPECTACLES WITHIN THE RADIO FREQUENCY RANGE 1.5 TO 3.0GHZ

This paper investigates changes in specific absorption rates due to metallic spectacles in close proximity with a head of representative electrical properties. Here, the FDTD method is used with a Z directed plane wave to simulate a personal digital assistant held in front of the face. Results confirm that metallic spectacles can significantly change SAR levels at frequencies between 1.5 and 3GHz. Specific attention is given to the energy interaction in the eyes and the nose. Results are given for several common spectacle frame shapes as well as whole head energy absorption comparisons.
Resveratrol decreases fructoseâ•’induced oxidative stress, mediated by <fc>NADPH</fc> oxidase via an <fc>AMPK</fc>â•’dependent mechanism

Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Division of General Internal Medicine, Department of Internal Medicine, Kaoshiung Medical University Hospital, Kaoshiung Medical University, Kaohsiung, Taiwan, Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan, Institute of Clinical Medicine, National Cheng-Kung University, Tainan, Taiwan, Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, Department of Anesthesiology, Yuli Veterans Hospital, Hualien, Taiwan, Department of Internal Medicine, Division of Cardiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan, Genomics Research Center, Academia Sinica, Taipei, Taiwan, and Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan Correspondence Ching-Jiunn Tseng, Department of Medical Education and Research, Kaohsiung Veterans General Hospital, 386 Ta-Chung 1st Rd., Kaohsiung 813, Taiwan. E-mail: cjtseng@vghks.gov. tw
Parámetros de Calidad y Metodologías para Determinar las Propiedades Físicas de Alimentos Extruidos para Peces

espanolEl presente trabajo relaciona los metodos tradicionales usados para analizar la calidad fisica de un alimento extruido para peces, como dureza, durabilidad, estabilidad en agua, velocidad de hundimiento, densidad aparente, capacidad de absorcion-perdida de aceite y porosidad como metodos para en el control de su produccion a nivel industrial. Las propiedades fisicas de los pellets son relevantes para la toma de decisiones relacionadas con las condiciones de procesamiento, transporte, almacenamiento, aprovechamiento biologico del animal y evaluacion de nuevas materias primas y aditivos. Existen diversos metodos para determinar la calidad fisica de los pellets. Sin embargo, en su mayoria se relacionan con alimentacion de animales terrestres, los cuales no son apropiados para la alimentacion de peces. Estos requieren condiciones de resistencia al estres mecanico y al mismo tiempo presentar una textura y tamano que facilite la ingesta adecuada del alimento en el agua. EnglishThe present work relates the traditional methods used to analyze the physical quality of fish extruded food, such as hardness, durability, water stability, sinking speed, bulk density, oil absorption and loss capacity and porosity as methods for the control of Its production at an industrial level. The physical properties of the pellets are relevant for decision making related to the conditions of processing, transport, storage, biological use of the animal and evaluation of new raw materials and additives. There are several methods for determining the physical quality of the pellets. However, they are mostly related to feeding of terrestrial animals, which are not suitable for feeding fish. These require conditions of resistance to mechanical stress and at the same time should have a texture and size that facilitates the adequate intake of food in the water.
Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy

Thomas M. Wishart,1,2 Chantal A. Mutsaers,1,3 Markus Riessland,4 Michell M. Reimer,1,5 Gillian Hunter,1,3 Marie L. Hannam,6 Samantha L. Eaton,2 Heidi R. Fuller,7 Sarah L. Roche,1,3 Eilidh Somers,1,3 Robert Morse,8 Philip J. Young,8 Douglas J. Lamont,9 Matthias Hammerschmidt,10 Anagha Joshi,11 Peter Hohenstein,11 Glenn E. Morris,7 Simon H. Parson,1,12 Paul A. Skehel,1,3 Thomas Becker,1,5 Iain M. Robinson,6 Catherina G. Becker,1,5 Brunhilde Wirth,4 and Thomas H. Gillingwater1,3
Identification of Central ‐ Pacific and Eastern ‐ Pacific types of ENSO in CMIP3 models

[ 1 ] Much understanding of the El Niño ‐ Southern Oscillation (ENSO) has been obtained from the analyses of the climate simulations produced for World Climate Research Programme ’ s Coupled Model Intercomparison Project phase 3 (CMIP3). However, most of these analyses do not consider the existence of the Eastern ‐ Pacific (EP) and Central ‐ Pacific (CP) types of ENSO events, which have been increasingly recognized as two distinct types of interannual sea surface temperature (SST) variation in the tropical Pacific. This study uses a regression ‐ Empirical Orthogonal Function method to identify how well these two ENSO types are captured in the pre ‐ industrial simulations of nineteen CMIP3 models. It is concluded that most CMIP3 models (13 out of 19) can produce realistically strong CP ENSOs, but only a few of them (9 out of 19) can produce realistically strong EP ENSOs. Six models that realistically simulate both the EP and CP ENSOs and their intensity ratio are identified. By separating the SST variability into these two types, it is further revealed that the leading periodicity of the simulated EP ENSO is linearly related to the latitudinal width of SST variability and varies from 1 to 5 years. As for the simulated CP ENSO, its leading periodicity is either 2 or 4 years depending on whether its SST variability is located to the east of the dateline or in the western ‐ Pacific warm pool, respectively. The identification produced in this study offers useful information to further understand the two types of ENSO using the CMIP3 models. Citation: Yu, J.-Y. , and S. T. Kim (2010), Identification of Central ‐ Pacific and Eastern ‐ Pacific types of ENSO in CMIP3 models, Geophys. Res. Lett.