Miracle-dz/UniFAR-FTUs huggingface dataset:
VALIDATION OF HORUS3D/N AGAINST TRIPOLI-4®D FOR CORE DEPLETION CALCULATION OF THE JULES HOROWITZ REACTOR

The international Jules Horowitz material testing Reactor (JHR) is under construction at CEA Cadarache research center, in southern France. Its first criticality is foreseen by the end of the decade. In order to perform JHR design and safety studies, a specific neutronics calculation tool, HORUS3D/N, based on the deterministic codes APOLLO2 and CRONOS2 and on the European nuclear data library JEFF3.1. 1, was developed to calculate JHR neutronics parameters taking into account fuel depletion: reactivity, power distribution, control rod reactivity worth, etc. Up to now, the biases and uncertainties on the different neutronics parameters computed with HORUS3D/N were assessed, in particular, by comparing HORUS3D/N deterministic calculations with reference route calculations based on APOLLO2-MOC and TRIPOLI-4®. The use for JHR of the recent Monte-Carlo TRIPOLI-4® in its new Depletion mode (TRIPOLI-4®D) will also allow providing biases for the main neutronics parameters under fuel depletion conditions. These biases will give a quantitative estimation of the impact of the approximations of the flux calculation in the deterministic route. This paper presents a contribution to the validation of HORUS3D/N based on the first comparisons between the calculations performed with APOLLO2-MOC and CRONOS2, and the ones from TRIPOLI-4®D. The study is performed on 2-D calculations for two different clusters in an infinite lattice configuration. It focuses on the main parameters of interest: isotopic concentrations, plate power distributions, reactivity, as functions of burnup. The results obtained show reasonable discrepancies with APOLLO2 calculation and allow to be confident on the APOLLO2.8/REL2005/CEA2005 package recommendations developed by CEA for light water reactor studies used in HORUS-3D/N. In particular, the main fuel isotopes are well predicted with TRIPOLI-4®D with discrepancies values lower than -1.5%.
Software quality assurance in SW-CMM2

With the development of information technology, software has become the primary part of many products. How to improve the software quality and make the software meet various application requirements, it has become the research subject widely concerned by every walk of life. This paper discusses one of the key process areas in CMM2-software quality assurance, including the purpose, activities, practices and problems that may be encountered, and presents the ways and steps that implements the SQA.
Impact of organizational culture, occupational commitment and industry-academy cooperation on vocational education in China: Cross-sectional Hierarchical Linear Modeling analysis

At a time when vocational education is seen as critical for national development, concern grows regarding how weak organizational culture and occupational commitment may threaten the production of quality graduates and teachers within the field. The failure of vocational institutions to effectively create human capital likely threatens the connections between Chinese industry and its educational institutions. This study thus explores how these connections are influenced by organizational and occupational factors. A multi-layer linear model is employed on data collected from 406 teachers from 69 Chinese vocational colleges and universities. Results suggest that organizational cultural positively influences industry-university cooperative behavior through the construction of strong occupational commitment and job involvement. This study not only enriches and expands new knowledge and academic perspectives, but also provides feasible policy suggestions to help guide educational administrators toward the improvement of vocational education.
Network pharmacology analysis and molecular docking to unveil the potential mechanisms of San-Huang-Chai-Zhu formula treating cholestasis

Objective Chinese medicine formulae possess the potential for cholestasis treatment. This study aimed to explore the underlying mechanisms of San-Huang-Chai-Zhu formula (SHCZF) against cholestasis. Methods The major chemical compounds of SHCZF were identified by high-performance liquid chromatography. The bioactive compounds and targets of SHCZF, and cholestasis-related targets were obtained from public databases. Intersected targets of SHCZF and cholestasis were visualized by Venn diagram. The protein-protein interaction and compound-target networks were established by Cytoscape according to the STRING database. The biological functions and pathways of potential targets were characterized by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis. The biological process-target-pathway network was constructed by Cytoscape. Finally, the interactions between biological compounds and hub target proteins were validated via molecular docking. Results There 7 major chemical compounds in SHCZF. A total of 141 bioactive compounds and 83 potential targets were screened for SHCZF against cholestasis. The process of SHCZF against cholestasis was mainly involved in AGE-RAGE signaling pathway in diabetic complications, fluid shear stress and atherosclerosis, and drug metabolism-cytochrome P450. ALB, IL6, AKT1, TP53, TNF, MAPK3, APOE, IL1B, PPARG, and PPARA were the top 10 hub targets. Molecular docking showed that bioactive compounds of SHCZF had a good binding affinity with hub targets. Conclusions This study predicted that the mechanisms of SHCZF against cholestasis mainly involved in AGE-RAGE signaling pathway in diabetic complications, fluid shear stress and atherosclerosis, and drug metabolism-cytochrome P450. Moreover, APOE, AKT1, and TP53 were the critical hub targets for bioactive compounds of SHCZF.
Factors affecting postural instability after more than one-year bilateral subthalamic stimulation in Parkinson’s disease: A cross-sectional study

Background Balance impairment in Parkinson’s disease is multifactorial and its changes due to subthalamic stimulation vary in different studies. Objective We aimed to analyze the combination of predictive clinical factors of balance impairment in patients with Parkinson’s disease treated with bilateral subthalamic stimulation for at least one year. Methods We recruited 24 patients with Parkinson’s disease treated with bilateral subthalamic stimulation and 24 healthy controls. They wore an Opal monitor (APDM Inc.) consisting of three-dimensional gyroscopes and accelerometers in the lumbar region. We investigated four stimulation conditions (bilateral stimulation OFF, bilateral stimulation ON, and unilateral right- and left-sided stimulation ON) with four tests: stance on a plain ground with eyes open and closed, stance on a foam platform with eyes open and closed. Age, disease duration, the time elapsed after implantation, levodopa, and stimulation responsiveness were analyzed. The distance of stimulation location from the subthalamic motor center was calculated individually in each plane of the three dimensions. We analyzed the sway values in the four stimulation conditions in the patient group and compared them with the control values. We explored factor combinations (with age as confounder) in the patient group predictive for imbalance with cluster analysis and a machine‐learning‐based multiple regression method. Results Sway combined from the four tasks did not differ in the patients and controls on a group level. The combination of the disease duration, the preoperative levodopa responsiveness, and the stimulation responsiveness predicted individual stimulation-induced static imbalance. The more affected patients had more severe motor symptoms; primarily, the proprioceptive followed by visual sensory feedback loss provoked imbalance in them when switching on the stimulation. Conclusions The duration of the disease, the severity of motor symptoms, the levodopa responsiveness, and additional sensory deficits should be carefully considered during preoperative evaluation to predict subthalamic stimulation-induced imbalance in Parkinson’s disease.
Unmet Prenatal Expectations During the COVID-19 Pandemic

Abstract Purpose: To explore the experiences of pregnant women who were living in the United States during the COVID-19 pandemic. Study Design and Methods: Using a qualitative design, we used data obtained from women in their second or third trimester of pregnancy who participated in the Perinatal Experiences and COVID-19 Effects (PEACE) Study from May 21 to December 22, 2020. Results: 361 of 408 pregnant women (88%) who participated in the PEACE study during that timeframe provided narrative comments. Participants had a mean age of 33.2 years (SD = 3.7) with a high percentage of White women (91.4%). At the time of participation, women were between 2.4 and 8.6 months into the COVID-19 pandemic. Just under half were pregnant for the first time (n = 177). Content analysis of responses revealed an overall sense of “unmet expectations” within two themes involving the role of relationships: 1) losing the experience of going through pregnancy together and 2) loss of social support and expected relationship building. Differences were noted between participants giving birth for the first time and participants with other children at home. Clinical Implications: This study offers insight for nurses and other clinicians taking care of pregnant women during times of public health crises and provides implications for the care of women as the pandemic continues. Nurses can help women plan for future health care changes that may disrupt their support needs as seen during the COVID-19 pandemic. Nurses should also be aware of possible enduring effects of prenatal unmet needs on later outcomes. Restrictions initiated by birthing hospitals and prenatal care providers significantly changed traditional routines for care during pregnancy to minimize risk of exposure to COVID-19 for pregnant women and their care givers. Many women attended prenatal visits alone and were unable to share the usual pregnancy milestones with their partners. In this study, women describe their unmet expectations for pregnancy in the context of these changes during the COVID-19 pandemic.
Increased dosage and treatment time of Epigallocatechin-3-gallate (EGCG) negatively affects skeletal parameters in normal mice and Down syndrome mouse models

Bone abnormalities affect all individuals with Down syndrome (DS) and are linked to abnormal expression of DYRK1A, a gene found in three copies in people with DS and Ts65Dn DS model mice. Previous work in Ts65Dn male mice demonstrated that both genetic normalization of Dyrk1a and treatment with ~9 mg/kg/day Epigallocatechin-3-gallate (EGCG), the main polyphenol found in green tea and putative DYRK1A inhibitor, improved some skeletal deficits. Because EGCG treatment improved mostly trabecular skeletal deficits, we hypothesized that increasing EGCG treatment dosage and length of administration would positively affect both trabecular and cortical bone in Ts65Dn mice. Treatment of individuals with DS with green tea extract (GTE) containing EGCG also showed some weight loss in individuals with DS, and we hypothesized that weights would be affected in Ts65Dn mice after EGCG treatment. Treatment with ~20 mg/kg/day EGCG for seven weeks showed no improvements in male Ts65Dn trabecular bone and only limited improvements in cortical measures. Comparing skeletal analyses after ~20mg/kg/day EGCG treatment with previously published treatments with ~9, 50, and 200 mg/kg/day EGCG showed that increased dosage and treatment time increased cortical structural deficits leading to weaker appendicular bones in male mice. Weight was not affected by treatment in mice, except for those given a high dose of EGCG by oral gavage. These data indicate that high doses of EGCG, similar to those reported in some treatment studies of DS and other disorders, may impair long bone structure and strength. Skeletal phenotypes should be monitored when high doses of EGCG are administered therapeutically.
The where and when of COVID-19: Using ecological and Twitter-based assessments to examine impacts in a temporal and community context

In March 2020, residents of the Bronx, New York experienced one of the first significant community COVID-19 outbreaks in the United States. Focusing on intensive longitudinal data from 78 Bronx-based older adults, we used a multi-method approach to (1) examine 2019 to early pandemic (February-June 2020) changes in momentary psychological well-being of Einstein Aging Study (EAS) participants and (2) to contextualize these changes with community distress scores collected from public Twitter posts posted in Bronx County. We found increases in mean loneliness from 2019 to 2020; and participants that were higher in neuroticism had greater increases in thought unpleasantness and feeling depressed. Twitter-based Bronx community scores of anxiety, depressivity, and negatively-valenced affect showed elevated levels in 2020 weeks relative to 2019. Integration of EAS participant data and community data showed week-to-week fluctuations across 2019 and 2020. Results highlight how community-level data can characterize a rapidly changing environment to supplement individual-level data at no additional burden to individual participants.
moc-6/MOCS2A is necessary for molybdenum cofactor synthesis in C. elegans

Molybdenum cofactor (Moco) is an essential prosthetic group that mediates the activity of 4 animal oxidases and is required for viability. Humans with mutations in the genes encoding Moco-biosynthetic enzymes suffer from Moco deficiency, a neonatal lethal inborn error of metabolism. Caenorhabditis elegans has recently emerged as a useful and tractable genetic discovery engine for Moco biology. Here, we identify and characterize K10D2.7/moc-6, the C. elegans ortholog of human MOCS2A, a sulfur-carrier protein essential for Moco synthesis. Using CRISPR/Cas9 gene editing, we generate 3 null mutations in K10D2.7/moc-6 and with these alleles genetically demonstrate that K10D2.7/moc-6 is necessary for endogenous Moco synthesis in C. elegans.
Virtually Augmented Self-Hypnosis applied to endovascular interventions (VA-HYPO): Randomized Controlled Trial Protocol

Endovascular interventions (EVI) are increasingly performed as minimally-invasive alternatives to surgery and have many advantages, including a decreased need for general anesthesia. However, EVI can be stressful for patients and often lead to anxiety and pain related to the procedure. The use of local anesthetics, anxiolytics, and analgesic drugs can help avoid general anesthesia. Nevertheless, these drugs have potential side effects. Alternative nonpharmacological therapies can improve patients’ experience during conscious interventions and reduce the need for additional medications. The added value of virtually augmented self-hypnosis (VA-HYPO) and its potential to reduce pain and anxiety during peripheral and visceral arterial and venous EVI is unknown. This is a prospective two-arm trial designed to randomize 100 patients in two groups according to the use or not of VA-HYPO during peripheral EVI as a complementary nonpharmacological technique to improve patient comfort. The main objective is to compare per-procedural anxiety, and the secondary aim is to compare the rated per-procedural pain in both groups. The potential significance is that VA-HYPO may improve patients’ experience during peripheral and visceral arterial and venous EVI and other minimally invasive interventions performed under local anesthesia. Trial registration: Our study is registered on clinicaltrials.gov, with trial registration number: NCT04561596.
The effect of visual and proprioceptive feedback on sensorimotor rhythms during BCI training

Brain–computer interfaces (BCI) can be designed with several feedback modalities. To promote appropriate brain plasticity in therapeutic applications, the feedback should guide the user to elicit the desired brain activity and preferably be similar to the imagined action. In this study, we employed magnetoencephalography (MEG) to measure neurophysiological changes in healthy subjects performing motor imagery (MI) -based BCI training with two different feedback modalities. The MI-BCI task used in this study lasted 40–60 min and involved imagery of right- or left-hand movements. 8 subjects performed the task with visual and 14 subjects with proprioceptive feedback. We analysed power changes across the session at multiple frequencies in the range of 4–40 Hz with a generalized linear model to find those frequencies at which the power increased significantly during training. In addition, the power increase was analysed for each gradiometer, separately for alpha (8–13 Hz), beta (14–30 Hz) and gamma (30–40 Hz) bands, to find channels showing significant linear power increase over the session. These analyses were applied during three different conditions: rest, preparation, and MI. Visual feedback enhanced the amplitude of mainly high beta and gamma bands (24–40 Hz) in all conditions in occipital and left temporal channels. During proprioceptive feedback, in contrast, power increased mainly in alpha and beta bands. The alpha-band enhancement was found in multiple parietal, occipital, and temporal channels in all conditions, whereas the beta-band increase occurred during rest and preparation mainly in the parieto-occipital region and during MI in the parietal channels above hand motor regions. Our results show that BCI training with proprioceptive feedback increases the power of sensorimotor rhythms in the motor cortex, whereas visual feedback causes mainly a gamma-band increase in the visual cortex. MI-BCIs should involve proprioceptive feedback to facilitate plasticity in the motor cortex.
Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions

Microglia modulate cerebral blood flow (CBF) through complex purinergic actions, which are mediated by dynamic, P2Y12 receptor-driven interactions with the vasculature. Microglial actions are partially independent of nitric oxide. Microglial dysfunction leads to impaired CBF response during neurovascular coupling, hypercapnia-induced vasodilation and cerebral hypoperfusion.
Children’s Reflection and Sympathy as Predictors of Reparative Behavior

Abstract This study investigated the links between reflection, sympathy, and reparative behavior in an ethnically diverse sample of 4-, 6- and 8-year-old children from Canada (N = 752). Primary caregivers responded to questionnaires assessing their children’s reflection, sympathy, and reparative behaviors. The links between these variables were examined using structural equation modeling. In accordance with our hypotheses, children’s reflection and sympathy were both related to reparation. We did not, however, find any interaction between reflection and sympathy in relation to reparation. These findings suggest that the pathways to reparative behavior through reflection (a cognitive capacity) and sympathy (an affective capacity) are independent. We discuss these findings in relation to the differential roles of cognitive and affective processes in promoting reparative behavior.
Hold the Antibiotics: Are Preoperative Antibiotics Unnecessary in the Treatment of Pediatric Supracondylar Humerus Fractures?

Background: Supracondylar humerus (SCH) fracture is the most common elbow injury in children and often treated with closed reduction and percutaneous pinning (CRPP). There is little published evidence supporting or refuting the use of perioperative prophylactic antibiotics for SCH CRPP in the pediatric population. The purpose of this study is to evaluate the rate of surgical site infection for patients with and without preoperative antibiotics. Methods: A retrospective chart review was conducted of patients less than or equal to 16 years from 2012 to 2018 who underwent primary CRPP. Open fractures, multilimbed polytraumas, and immunodeficient patients were excluded. Infection rates were compared using a noninferiority test assuming a 3% infection rate and a predefined noninferiority margin of 4%. A total of 255 patients were needed to adequately power the study. Results: Of the 1253 cases identified, 845 met eligibility criteria. A total of 337 received antibiotics, and 508 did not. Preoperative nerve injury (P=0.0244) and sterilization technique (P<0.0001) were associated with antibiotic use: 4 patients developed an infection; there were successfully treated superficial infections, and 1 was a deep infection requiring a formal debridement. There were 8 patients that had a recorded mal-union, and 6 patients required additional procedures; 1 patient had a postoperative compartment syndrome on postoperation day 1. The infection rates among patients treated with and without antibiotics were 0.60% and 0.40%, respectively. The absence of antibiotics was not clinically inferior to using antibiotics (P=0.003). Conclusions: Infection remains a rare complication following CRPP of SCH fractures. According to our current data, not giving perioperative antibiotics was not inferior to using perioperative antibiotics for preventing superficial or deep infection in patients undergoing CRPP of SCH fractures. With the increase in attention to antibiotic stewardship, it is important to eliminate unnecessary antibiotic use while continuing to maintain a low rate of surgical site infection. Level of Evidence: Level IV—case series. This is a therapeutic study that investigates the results from a case series.
Kidney Sellers From a Village in Nepal: Protocol for an Ethnographic Study

Background Kidney selling is a global phenomenon, with higher-income countries functioning as recipients and lower-income countries as donors, reflecting the gaps due to poverty and vulnerability. In recent years, an increasing number of residents in a village near the capital city of Nepal have been selling their kidneys; however, the factors embedded in the local social, cultural, political, and individual context driving kidney selling are poorly understood. Objective The aim of this study is to explore the drivers of kidney selling and its consequences in Hokse village in central Nepal, using ethnographic methods and multistakeholder consultations. Methods An ethnographic approach will be adopted along with in-depth interviews and key informant interviews among the residents and kidney sellers in the village. Relevant participants in the village will be selected purposively using a snowball approach. The number of participants will be predicated on the principles of data saturation. In addition, consultations with relevant stakeholders will be conducted at various levels, which will include authorities within and outside the village, and policymakers. All interviews will be conducted face to face, audio-recorded for transcription, and subjected to a thematic analysis. Results This study was approved by Mahidol University Central Institutional Review Board (MU-CIRB 2020/217.1808) in September 2020 and by Nepal Health Research Council (NHRC 716/2020 PhD) in January 2021. The fieldwork started in February 2021 and the data analysis was completed in September 2021. Conclusions This study is expected to provide insight into the reasons underlying the practice of kidney selling based on the example of Hokse village, along with the perspectives of multiple stakeholders. International Registered Report Identifier (IRRID) DERR1-10.2196/29364