Miracle-dz/UniFAR-FTUs huggingface dataset:
Automated Quantitative Analyses of Fatigue-Induced Surface Damage by Deep Learning

The digitization of materials is the prerequisite for accelerating product development. However, technologically, this is only beneficial when reliability is maintained. This requires comprehension of the microstructure-driven fatigue damage mechanisms across scales. A substantial fraction of the lifetime for high performance materials is attributed to surface damage accumulation at the microstructural scale (e.g., extrusions and micro crack formation). Although, its modeling is impeded by a lack of comprehensive understanding of the related mechanisms. This makes statistical validation at the same scale by micromechanical experimentation a fundamental requirement. Hence, a large quantity of processed experimental data, which can only be acquired by automated experiments and data analyses, is crucial. Surface damage evolution is often accessed by imaging and subsequent image post-processing. In this work, we evaluated deep learning (DL) methodologies for semantic segmentation and different image processing approaches for quantitative slip trace characterization. Due to limited annotated data, a U-Net architecture was utilized. Three data sets of damage locations observed in scanning electron microscope (SEM) images of ferritic steel, martensitic steel, and copper specimens were prepared. In order to allow the developed models to cope with material-specific damage morphology and imaging-induced variance, a customized augmentation pipeline for the input images was developed. Material domain generalizability of ferritic steel and conjunct material trained models were tested successfully. Multiple image processing routines to detect slip trace orientation (STO) from the DL segmented extrusion areas were implemented and assessed. In conclusion, generalization to multiple materials has been achieved for the DL methodology, suggesting that extending it well beyond fatigue damage is feasible.
De novo Transcriptome of the Non-saxitoxin Producing Alexandrium tamutum Reveals New Insights on Harmful Dinoflagellates

Many dinoflagellates species, especially of the Alexandrium genus, produce a series of toxins with tremendous impacts on human and environmental health, and tourism economies. Alexandrium tamutum was discovered for the first time in the Gulf of Naples, and it is not known to produce saxitoxins. However, a clone of A. tamutum from the same Gulf showed copepod reproduction impairment and antiproliferative activity. In this study, the full transcriptome of the dinoflagellate A. tamutum is presented in both control and phosphate starvation conditions. RNA-seq approach was used for in silico identification of transcripts that can be involved in the synthesis of toxic compounds. Phosphate starvation was selected because it is known to induce toxin production for other Alexandrium spp. Results showed the presence of three transcripts related to saxitoxin synthesis (sxtA, sxtG and sxtU), and others potentially related to the synthesis of additional toxic compounds (e.g., 44 transcripts annotated as “polyketide synthase”). These data suggest that even if this A. tamutum clone does not produce saxitoxins, it has the potential to produce toxic metabolites, in line with the previously observed activity. These data give new insights into toxic microalgae, toxin production and their potential applications for the treatment of human pathologies.
The Fluff test: Improved scoring system to account for different degrees of contralesional and ipsilesional personal neglect in brain damaged patients

ABSTRACT The Fluff test is a simple test to assess evidence of personal neglect (PN) in brain-damaged patients. While blindfolded, patients are asked to remove targets previously attached to their body and the number of targets detached provides information about possible spatial bias. This test has been widely used for clinical and research purposes. However, the current scoring system presents some limitations, which make difficult to interpret patients’ performance in terms of both contralalesional and ipsilesional PN when they omit targets on the ipsilesional side. Moreover, it does not consider possible confounding variables, such as non-spatial cognitive deficits or lack of compliance that may affect patients’ performance and lead to incorrect diagnosis. The present paper proposes a new scoring method overcoming the limitations mentioned above and it analyses data from a large sample of 243 brain-damaged patients. Findings showed that contralesional PN was significantly more severe, but not more frequent, following right (31%) than left (21%) brain damage. We also found evidence of left ipsilesional PN and cases of potential mis-diagnosis that would have passed unnoticed with the original scoring system. The new scoring method allows to identify different degrees of contralesional and ipsilesional PN and potential confounding variable.
Short-term Effects of Burning and Disking on Songbird Use of Floodplain Conservation Easements

Abstract Extensive conversion of Midwestern riparian areas for agricultural production has had many consequences including reduced habitat for nesting birds. However, more than 120,000 ha of riparian habitat have been restored in this region through USDA conservation programs. In 2001 and 2002, we assessed songbird responses to burning and disking for management of conservation easements in east-central Iowa. We randomly assigned herbaceous riparian fields to burning and disking treatments and collected data on density and species richness of songbirds in these habitats. Total density of grassland and wetland species and red-winged blackbirds (Agelaius phoeniceus) were reduced by burning in the first and second breeding seasons after burning; common yellowthroat (Geothlypis trichas) density decreased with burning only in the first season. Disking led to increased density of grassland and wetland birds and greater overall avian conservation value on treated relative to untreated fields in the year after treatment. Changes associated with burning and disking treatments were likely related to changes in both vegetation structure and abundance of arthropod food resources. Despite decreased bird densities with burning, fire is a necessary management tool to control woody vegetation. Overall, both burning and disking appear to be effective management practices for maintaining herbaceous riparian habitats for grassland birds.
Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection

Combining diagnosis with therapy, magnetic iron oxide nanoparticles (INOPs) act as an important vehicle for drug delivery. However, poor biocompatibility of INOPs limits their application. To improve the shortcomings, various surface modifications have been developed, including small molecules coatings, polymers coatings, lipid coatings and lipopolymer coatings. These surface modifications facilitate iron nanoparticles to cross the blood-brain-barrier, which is essential for diagnosis and treatments of brain diseases. Here we focus on the characteristics of different coated INOPs and their application in brain disease, particularly gliomas, Alzheimer’s disease (AD) and Parkinson’s disease (PD). Moreover, we summarize the current progress and expect to provide help for future researches.
ABC score: a new risk score that accurately predicts mortality in acute upper and lower gastrointestinal bleeding: an international multicentre study

Objectives Existing scores are not accurate at predicting mortality in upper (UGIB) and lower (LGIB) gastrointestinal bleeding. We aimed to develop and validate a new pre-endoscopy score for predicting mortality in both UGIB and LGIB. Design and setting International cohort study. Patients presenting to hospital with UGIB at six international centres were used to develop a risk score for predicting mortality using regression analyses. The score’s performance in UGIB and LGIB was externally validated and compared with existing scores using four international datasets. We calculated areas under receiver operating characteristics curves (AUROCs), sensitivities, specificities and outcome among patients classified as low risk and high risk. Participants and results We included 3012 UGIB patients in the development cohort, and 4019 UGIB and 2336 LGIB patients in the validation cohorts. Age, Blood tests and Comorbidities (ABC) score was closer associated with mortality in UGIB and LGIB (AUROCs: 0.81–84) than existing scores (AUROCs: 0.65–0.75; p≤0.02). In UGIB, patients with low ABC score (≤3), medium ABC score (4–7) and high ABC score (≥8) had 30-day mortality rates of 1.0%, 7.0% and 25%, respectively. Patients classified low risk using ABC score had lower mortality than those classified low risk with AIMS65 (threshold ≤1) (1.0 vs 4.5%; p<0.001). In LGIB, patients with low, medium and high ABC scores had in-hospital mortality rates of 0.6%, 6.3% and 18%, respectively. Conclusions In contrast to previous scores, ABC score has good performance for predicting mortality in both UGIB and LGIB, allowing early identification and targeted management of patients at high or low risk of death.
Crebradomus and Dissimularia, new genera in the family Chondrymeniaceae (Gigartinales, Rhodophyta) from the central, southern and western Pacific Ocean

Abstract: Two new genera of tropical-/subtropical-Pacific macroalgae are proposed. The monotypic Crebradomus gen. nov., based on C. gongylocarpus sp. nov., is restricted to Lord Howe Island in the southern Australasian-Pacific Ocean. Dissimularia gen. nov. consists of the type species, D. dactylocarpa sp. nov., from its Lord Howe Island type locality, as well as from the Hawaiian Islands, Guam and possibly Burma and the southern Great Barrier Reef, plus three geographically restricted, virtually cryptic species from small islands or atolls in Samoa and Micronesia. The long-problematical ‘Cryptonemia? umbraticola’ is shown on the basis of molecular studies of recent collections from its type locality, remote Palmyra Atoll, to represent a distinct species of Dissimularia, D. umbraticola comb. nov., with D. tauensis sp. nov. and D. withallii sp. nov. from Tau and Jarvis Islands, respectively, also belonging to this complex. Morphological features common to these taxa included turf-like, often imbricate thin blades of irregular contour, thalli that tended to occupy shaded habitats on coral reefs between 1.5- and 40-m depths, and blade sections that consisted of a shallow anticlinal cortex and a broad, lax to densely compact medulla of mostly periclinal filaments interspersed with varying numbers of anticlinally and obliquely traversing filaments. Only Crebredomus was found cystocarpic, the carposporophytes densely aggregated in verrucose marginal pods and consisting of a lengthy narrow fusion cell of irregular contours and a candelabra-shaped distal cluster of gonimoblast filaments bearing terminal chains of two or three carposporangia beneath a narrow ostiole. Male gametophytes and tetrasporophytes remain unknown in both genera. Molecular data indicated the generic distinctness of Crebradomus and Dissimularia, as well as the whole complex as members of the recently designated family Chondrymeniaceae of the order Gigartinales.
Microbial β-Glucanases Different from Cellulases

AbstractThe β-glucans different from cellulose are the most abundant class of polysaccharides. They are found in microorganisms and higher plants as structural entities of cell wall, as cytoplasmic and vacuolar reserve materials, and as extracellular substances. Enzyme systems capable to hydrolyze β-glucans are produced by different microorganisms. The occurrence and nature of β-glucanases and their substrates are reviewed. The regulation of biosynthesis of these enzymes, their properties, substrate and product specificities, mode of action and molecular cloning are described. The participation of β-glucanases in the morphogenetic events of yeast cell is presented. The role and synergism of different types of 1,3-β-glucanases in microbial cell wall lysis and the potential application for isolation of intracellular materials like proteins, carbohydrates, enzymes and as an analytical tool are discussed in the light of current knowledge.
Stable Pleistocene-Era Populations of Chaerephon pumilus (Chiroptera: Molossidae) in Southeastern Africa do not use Different Echolocation Calls

Our extension of the phylogenetic study of Taylor et al. (2009) on a larger, more geographically representative sample confirmed their finding of genetically distinct sympatric lineages of bats currently referred to as Chaerephon pumilus sensu lato (s.l.) (family Molossidae) in southeastern Africa. Chaerephon pumilus s.l. comprised two cytochrome b lineages separated by a mean genetic distance of 0.7% (0.1–1.4%), consistent with intraspecific variability. The C. pumilus s.l. clade was paraphyletic, containing a nested C. leucogaster (Madagascar) clade. As well as the expected four mitochondrial control region lineages, we identified a new strongly-supported clade from the Durban area. Indices of diversity and neutrality, combined with a ragged multimodal mismatch distribution, are inconsistent with demographic expansion of a single C. pumilus s.l. population in southeastern Africa, and suggest that the control region lineages are stable units at demographic equilibrium. Dating analyses suggest that these lineages were established during the late Pleistocene, between 60 000 and 13 000 years ago. We found no evidence to support our hypothesis that the sympatric genetic lineages of C. pumilus s.l. are associated with distinct sonotypes, as discriminant function analysis based on four echolocation parameters could not discriminate between the four clades. We hypothesise that the different genetic lineages may be distinguished by differences in social communication and behaviour.
Improvement of RT‐PCR Based Detection of Two Closteroviruses Associated with Little Cherry Disease in Sweet Cherries

The increasing availability of nucleotide sequence data from plant pathogenic fruit tree viruses led recently to the development of nucleic-acid-based detection methods as a routine tool for diagnosis. We present a simplification and modification of the previously described test procedure for the two closteroviruses Little cherry virus 1 and 2 (LChV-1, LChV-2). For LChV-1, a single tube reaction reduced unspecific amplification that led to false positive results. For the detection of LChV-2, a primer set was developed for the local isolates of the area ‘Altes Land’ in the northern part of Germany. To determine the optimal sampling conditions for a reliable detection of both viruses different types of tissue (bark, bud, leaves) were tested in monthly intervals.
Expansive learning in medical education: Putting Change Laboratory to work

Abstract This paper explores the purposeful use of conceptual and methodological tools provided by Cultural Historical Activity Theory (CHAT) to transform learning cultures and practices within and across diverse clinical learning environments. We describe how Change Laboratory methodology helped clinicians and others who support student, intern, and resident education to make changes collaboratively. A case study in undergraduate medical education shows how this created new forms of medical student placement and a postgraduate study shows how it addressed supervisors’ undermining behaviour towards Obstetrics and Gynaecology residents. This empirical work illustrates ways of modifying the classical Change Laboratory process to fit local contexts, resources, and needs. We conclude with lessons learned and future directions for practitioner-researchers who wish to broaden the range of methodological tools they use to transform clinical learning environments.
Promises and Pitfalls of Health Information Technology for Home- and Community-Based Services

Background: Health information technology (HIT) use in home- and community-based services (HCBS) has been hindered by inadequate resources and incentives to support modernization. We sought to understand the ways the Medicaid Balancing Incentive Program (BIP) facilitated increased use of HIT to increase access to HCBS. Method: Qualitative analysis of interviews with 30 Medicaid administrators, service agency providers, and consumer advocates. Results: Although stakeholders perceived several benefits to greater HIT use, they highlighted critical challenges to effective adoption within the long-term services and supports (LTSS) system, including lack of extant expertise/knowledge about HIT, the limited reach of HIT among rural and disabled beneficiaries, burdensome procurement processes, and the ongoing resources required to maintain up-to-date HIT solutions. Conclusion: The structural reforms required by BIP gave states an opportunity to modernize their HCBS systems through use of HIT. However, barriers to HIT adoption persist, underscoring the need for continued support as part of future rebalancing efforts.
Firearm ownership among young adults: Associations with impulsivity and impulse control disorders.

BACKGROUND Firearm ownership is extremely common in parts of the United States. Yet little research has examined whether it is associated with impulsive symptoms and traits. METHODS Adults age 18 to 29 who gamble at least occasionally were recruited in 2 cities in the United States using media advertisements for an exploratory study examining general mental health, impulse control disorders, impulsive personality, and aspects of cognition (decision-making, response inhibition, and flexible responding). The participants were grouped as firearm owners and non-firearm owners; these 2 groups were compared on the above measures. RESULTS For this study, 149 young adults took part, of whom 33 (22.1%) endorsed owning ≥1 firearm. Firearm ownership was significantly associated with male gender and elevated risk of gambling disorder, but not with other measures of impulsivity. CONCLUSIONS The link between firearm ownership and disordered gambling merits further research and may have policy implications, such as in terms of screening for guns in gambling arenas, including casinos. Further research is needed to explore potential associations between gun ownership and impulsivity in cohorts with other demographic characteristics, including longitudinally.
Classification techniques for adaptive distributed networks and aeronautical structures.

This master thesis is the result of a collaborative work between EMBRAER and the Escola Politécnica da USP for the study of structural health monitoring (SHM) techniques using sensors applied to aircraft structures. The goal was to develop classification techniques to discriminate between different events arising in the aircraft structure during tests; in the short term, improving the current SHM system used by EMBRAER, based on acoustic emission and, in the long term, fostering the development of a fully distributed system. As a result of studying classification methods for immediate use, we developed two techniques: the Spectral Similarity and a Support Vector Machines (SVM) classifier. Both are unsupervised solutions, due to the unlabeled nature of the data provided. The two solutions were delivered as a final product to EMBRAER for prompt use in the existing SHM system. By studying distributed solutions for future implementations, we developed a detection algorithm based on adaptive techniques. The main result was a special initialization for a maximum likelihood (ML) detector that yields an exponential decay rate in the error probability to a nonzero steady state, using adaptive diffusion estimation in a distributed sensor network. The nodes that compose the network must decide, locally, between two concurrent hypotheses concerning the environment state where they are inserted, using local measurements and shared estimates coming from their neighbors. The exponential performance does not depend on the adaptation step size value, provided it is sufficiently small. The results concerning this distributed detector were published in the journal IEEE Signal Processing Letters.
Ultimately Bounded Filtering for Time-Delayed Nonlinear Stochastic Systems with Uniform Quantizations under Random Access Protocol

This paper investigates the ultimately bounded filtering problem for a kind of time-delay nonlinear stochastic systems with random access protocol (RAP) and uniform quantization effects (UQEs). In order to reduce the occurrence of data conflicts, the RAP is employed to regulate the information transmissions over the shared communication channel. The scheduling behavior of the RAP is characterized by a Markov chain with known transition probabilities. On the other hand, the measurement outputs are quantized by the uniform quantizer before being transmitted via the communication channel. The objective of this paper is to devise a nonlinear filter such that, in the simultaneous presence of RAP and UQEs, the filtering error dynamics is exponentially ultimately bounded in mean square (EUBMS). By resorting to the stochastic analysis technique and the Lyapunov stability theory, sufficient conditions are obtained under which the desired nonlinear filter exists, and then the filter design algorithm is presented. At last, two simulation examples are given to validate the proposed filtering strategy.
Peroxisome Proliferator-Activated Receptor Beta/Delta Agonist Suppresses Inflammation and Promotes Neovascularization

The effects of peroxisome proliferator-activated receptor (PPAR)β/δ ophthalmic solution were investigated in a rat corneal alkali burn model. After alkali injury, GW501516 (PPARβ/δ agonist) or vehicle ophthalmic solution was topically instilled onto the rat’s cornea twice a day until day 7. Pathological findings were evaluated, and real-time reverse transcription polymerase chain reaction was performed. GW501516 strongly suppressed infiltration of neutrophils and pan-macrophages, and reduced the mRNA expression of interleukin-6, interleukin-1β, tumor necrosis factor alpha, and nuclear factor-kappa B. On the other hand, GW501516 promoted infiltration of M2 macrophages, infiltration of vascular endothelial cells associated with neovascularization in the wounded area, and expression of vascular endothelial growth factor A mRNA. However, 7-day administration of GW501516 did not promote neovascularization in uninjured normal corneas. Thus, the PPARβ/δ ligand suppressed inflammation and promoted neovascularization in the corneal wound healing process. These results will help to elucidate the role of PPARβ/δ in the field of ophthalmology.
Molecular detection of Vibrio spp. in lobster hemolymph

The occurrence of various Vibrio species in lobster hemolymph from the Persian Gulf was studied. A total number of 60 lobsters (Panulirus homarus) were caught from south coast of Iran and were studied to identify Vibrio spp. in hemolymph. Four Vibrio species includingVibrio alginolyticus, Vibrio vulnificus, Vibrio harveyi and Vibrio mimicus were identified using biochemical and molecular methods. Six lobsters (10%) contained one or moreVibrio spp. as 4 samples contained V. alginolyticus, one contained V. vulnificus and one species contained both V. harveyi and V. mimicus and none of samples contained V. parahemolyticus and V. cholera. Key word: Persian Gulf, vibriosis, Panulirus homarus.