Miracle-dz/UniFAR-FTUs huggingface dataset:
CD8 T Lymphocyte Responses to Human Herpesvirus 8 Lytic and Latency Proteins

Human herpesvirus 8 (HHV-8) is a lymphotropic gammaherpesvirus that causes Kaposi's sarcoma (KS), a vascular tumor of spindle-shaped endothelial cells. The importance of determining effective prevention and treatment for HHV-8 infection is evident in that KS continues to be the most common cancer among HIV-1 and AIDS patients. It is postulated that CD8+ T cell responses play an important role in controlling HHV-8 infection and preventing KS. However, there are minimal data supporting the role for T cell immunity in control of HHV-8 infection. Therefore, I investigated CD8+ T cell responses to HHV-8 lytic and latency proteins. I used our dendritic cell-based system in an IFN-γ ELISPOT to identify novel epitopes in healthy, HHV-8 seropositive individuals, then further assessed new epitopes for immune mediators using polychromatic flow cytometry. I also used multimer complexes to directly detect HHV-8-specific CD8+ T cells in blood. I investigated the effect of regulatory T cells (Treg) on these anti-HHV-8 T cell responses by depleting samples of Treg. I then applied these assays to patients in the Multicenter AIDS Cohort Study to longitudinally investigate the role of these responses during the progression to KS. Through these studies, I identified 10 novel HLA A*0201-restricted epitopes, which activated both monofunctional and polyfunctional CD8+ T cells producing various combinations of immune mediators. Responses were lower over many years prior to development of KS. Although CD8+ T cell IFN-γ responses were modest, a low but consistent percent of HHV-8-specific CD8+ T cells were present in blood, suggesting a functional down-regulation of this response. In support of this, removal of Treg enhanced CD8+ T cell responses to HHV-8 epitopes, and numbers of Treg increased prior to KS development. Overall, these data support that T cell responses, in frequency, magnitude and quality, are essential for the control of HHV-8 infection to prevent disease development. They also indicate that these antiviral T cell responses are in part controlled by Treg. Involvement of CD8+ T cells and Treg in control of HHV-8 infection has public health significance through implications for understanding the immunopathogenesis of HHV-8 needed for prevention and treatment of KS.
There is a critical weight range for Australia's declining tropical mammals

Many mammals in Australia's tropical north are in severe decline, yet understanding of the drivers of this decline is remarkably limited. Recently, Fisher et al. (Global Ecology and Biogeography, 2014, 23, 181−190) examined the traits that are associated with declining marsupial species in northern Australia. They concluded that, in this region, declines are most pronounced in the smallest species (those with the lowest body mass). This is in strong contrast to the significant declines that occurred earlier in central and southern Australia before the mid 20th century, which were most pronounced in medium-sized species, the so-called ‘critical weight range’ (35−5500 g). Here we show that Fisher et al. have misinterpreted their dataset; in northern Australia, the pattern of mammal decline in relation to body mass is remarkably similar to that in central and southern Australia, with mammal decline strongly concentrated in the critical weight range, suggesting fundamentally similar drivers between north and south.
Heading Estimation for Multimode Pedestrian Dead Reckoning

The flexible carrying mode of smartphone brings challenge for Pedestrian Dead Reckoning (PDR) especially for heading estimation with build-in sensors. This paper focuses on POCKET mode and SWING mode and analyzes the correlation between smartphone’s rotational motion and pedestrian’s walking cycle states and walking direction. Based on the analysis, we propose to use the rotation vector sensor data of smartphone within one walking step to estimate the pedestrian’s heading. For POCKET mode, heading is estimated by an improved rotational approach (IRA). A jitter detection algorithm is proposed to extract leg flexion interval. Stable walking direction without 180° ambiguity is obtained from the averaged rotation axis. For SWING mode, a single-point (SP) method is proposed. Heading is estimated from the direction of smartphone’s y-axis when it is closest to the horizontal plane. The algorithms are validated with data collected by HUAWEI mate 10 smartphone. The RMS errors are less than 4.37° and 3.38° for POCKET and SWING mode respectively. Superior to previous heading estimation algorithms, our method can converge within one single walking step for both carrying modes without 180° ambiguity.
A modified pseudospectral method for indirect solving a class of switching optimal control problems

In the present paper, an efficient pseudospectral method for solving the Hamiltonian boundary value problems arising from a class of switching optimal control problems is presented. For this purpose, based on the Pontryagin's minimum principle, the first-order necessary conditions of optimality are derived. Then, by partitioning the time interval related to the problem under study into some subintervals, the states (and costates) and control functions are approximated on each subintervals with piecewise interpolating polynomials based on Legendre–Gauss–Radau points and a piecewise constant function, respectively. As a result, solution of the problem is turned into solution of a number of algebraic equations, in which the values of the states (and costates) and control functions at Legendre–Gauss–Radau points as well as switching and terminal points are allowed to be unknown. Numerical examples are presented at the end to show the efficiency of the proposed method.
Defining the degree of work attractiveness in the Protected Housing service in Bulgaria

ABSTRACT This research-based article examines the challenges that social workers are facing in the context of intense reforms and transformations in a period of transition from centralised and institutionalised system of social care towards a decentralised and deinstitutionalised one. Key issues for social workers are determined through an exhaustive empirical study, assessing the degree of subjective attractiveness of the professional activity of social workers in the Protected housing service in Bulgaria. The study aims to give insights on what components of working conditions need to be improved to provide adequate support to social workers, enabling them to offer quality service to users. The study further analyses how workers prioritise these components, how the desired state differs from their current work situation and how work attractiveness relates to socio-demographic characteristics. The results show a low degree of work attractiveness and discrepancies on factors across the board between what social workers’ rate as significant for work to be attractive and their actual work situation. When considering the findings within the wider European context, the authors suggest the Bulgarian experience is of significance for other societies going through fast and fundamental transformations.
CD-VulD: Cross-Domain Vulnerability Discovery Based on Deep Domain Adaptation

A major cause of security incidents such as cyber attacks is rooted in software vulnerabilities. These vulnerabilities should ideally be found and fixed before the code gets deployed. Machine learning-based approaches achieve state-of-the-art performance in capturing vulnerabilities. These methods are predominantly supervised. Their prediction models are trained on a set of ground truth data where the training data and test data are assumed to be drawn from the same probability distribution. However, in practice, the test data often differs from the training data in terms of distribution because they are from different projects or they differ in the types of vulnerability. In this article, we present a new system for Cross Domain Software Vulnerability Discovery (CD-VulD) using deep learning (DL) and domain adaptation (DA). We employ DL because it has the capacity of automatically constructing high-level abstract feature representations of programs, which are likely of more cross-domain useful than the handcrafted features driven by domain knowledge. The divergence between distributions is reduced by learning cross-domain representations. First, given software program representations, CD-VulD converts them into token sequences and learns the token embeddings for generalization across tokens. Next, CD-VulD employs a deep feature model to build abstract high-level presentations based on those sequences. Then, the metric transfer learning framework (MTLF) technique is employed to learn cross-domain representations by minimizing the distribution divergence between the source domain and the target domain. Finally, the cross-domain representations are used to build a classifier for vulnerability detection. Experimental results show that CD-VulD outperforms the state-of-the-art vulnerability detection approaches by a wide margin. We make the new datasets publicly available so that our work is replicable and can be further improved.
MORE THAN MEETS THE EYE IN A PATIENT WITH PCOS: ANDROGEN-SECRETING GRANULOSA CELL OVARIAN TUMOR IN A VIRILIZED WOMAN WITH POLYCYSTIC OVARIAN SYNDROME (PCOS).

Objective Granulosa cell ovarian tumors are known to secrete estrogen. Herein we report a patient presenting with primary amenorrhea and virilization with markedly high androgen levels, all thought to be disproportional to be attributed to polycystic ovary syndrome (PCOS) alone. Bilateral oophorectomy revealed a rare androgen-secreting granulosa cell ovarian tumor and bilateral cysts (PCOS) both contributing to manifestations. Methods Description of a case and discussion of the literature. Results A 25-year-old female presented with primary amenorrhea, male pattern baldness and hirsutism of the face and chest, clitoral hypertrophy, cystic acne on the chest and shoulders, and type 2 diabetes. Diagnosis of PCOS was made at age 13 years. The concurrent presence of congenital adrenal hyperplasia was also considered. She was receiving metformin, oral contraceptives, and/or spironolactone with no improvement in manifestations at presentation to the endocrine clinic. She reported several elevated serum testosterone and androstenedione levels. Diagnosis of PCOS was established by the presence of enlarged cystic ovaries on ultrasound examination. The patient reported worsening manifestations including progression of diabetes despite therapy with metformin. She shaved her face, chest, and breasts daily for cosmetic reasons. Laboratory testing demonstrated markedly elevated total testosterone level (234 ng/dL), and normal cortisol and adrenocorticotropic hormone levels. Dexamethasone suppression and human chorionic gonadotropin stimulation indicated ovaries as a probable source of excessive circulating androgen levels. A computed tomography scan of the abdomen and pelvis showed multiple cysts in both ovaries, the largest being 1.9 cm in the right ovary. Due to the severity of manifestations, the patient was counseled to undergo fluoroscopically guided blood sampling of bilateral adrenal and ovarian veins, which confirmed both ovaries to be the source of the excess androgen production with a greater contribution by the right ovary. The patient underwent bilateral oophorectomy. Pathologic examination confirmed the presence of bilateral polycystic ovaries as well as an androgen-secreting granulosa cell tumor in the right ovary which apparently contributed to greater androgen levels in a right ovarian venous blood sample. Peripheral venous androgen levels normalized promptly after bilateral oophorectomy. Gradual resolution of clinical manifestations followed. Conclusion A unique presentation of granulosa cell ovarian tumor with concurrent PCOS contributing to the extremely excessive production of androgens in a young woman manifesting primary amenorrhea and masculinization at the onset of puberty with marked gradual resolution of manifestations following bilateral oophorectomy.
Trichoptera Kirby (Insecta) immature fauna from Rio das Almas Basin and Rio Paranã, Goiás State, Brazil, with new records for some genera

This paper deals with the Trichoptera immature fauna collected in 101 streams in Rio das Almas Basin during August-October 2008 and in Rio Parana, Iaciara-GO municipality, on August 2003, using kick-nets with 0.025 m2 of opening and 2 mm mesh. We record four new genera for Goias State, expanding records of genera from 33 to 37 and contributing to the Trichoptera fauna knowledge in Central Brazil.
Molecular markers in plants.

Molecular Markers in Plants surveys an array of technologies used in the molecular analysis of plants. The role molecular markers play in plant improvement has grown significantly as DNA sequencing and high-throughput technologies have matured. This timely review of technologies and techniques will provide readers with a useful resource on the latest molecular technologies. Molecular Markers in Plants not only reviews past achievements, but also catalogs recent advances and looks forward towards the future application of molecular technologies in plant improvement. Opening chapters look at the development of molecular technologies. Subsequent chapters look at a wide range of applications for the use of these advances in fields as diverse as plant breeding, production, biosecurity, and conservation. The final chapters look forward toward future developments in the field. Looking broadly at the field of molecular technologies, Molecular Markers in Plants will be an essential addition to the library of every researcher, institution, and company working in the field of plant improvement.
Psychological and Social Adjustment as Antecedents of High School Students’ Future Expectations

Abstract This study examines the association between psychosocial adjustment and future expectations in early adolescence. This research tries to fill some gaps in the literature on how current adjustment might be an antecedent of early adolescents’ future expectations. Participants were 781 students (mean age = 12.37 years). Data were collected in 11 schools. The results revealed statistically significant correlations between self-esteem, life satisfaction, self-efficacy, emotional and behavioural problems, educational and social adjustment, and future expectations. The structural equation model confirmed a positive relation between psychosocial adjustment and these adolescents’ future expectations. The main contribution of this research is to further our comprehension of the development of adolescents’ future expectations and the way in which psychosocial adjustment has an impact on such development. Future expectations are an important protective factor for healthy development in adolescence, as thinking about the future motivates everyday behaviour and influences choices, decisions and future activities.
Adaptive Anisotropic Unstructured Mesh Generation Method Based on Fluid Relaxation Analogy

In this paper, we extend the method (Fu et al., [1]) to anisotropic meshes by introducing an adaptive SPH (ASPH) concept with ellipsoidal kernels. First, anisotropic target feature-size and density functions, taking into account the effects of singularities, are deﬁned based on the level-set methodology. Second, ASPH is developed such that the particle distribution relaxes towards the target functions. In order to prevent SPH particles from escaping the mesh generation regions, a ghost surface particle method is proposed in combination with a tailored interaction strategy. Necessary adaptations of supporting numerical algorithms, such as fast neighbor search, for enforcing mesh anisotropy are addressed. Finally, unstructured meshes are generated by an anisotropic Delaunay triangulation conforming to the Riemannian metrics for the resulting particle conﬁguration. The performance of the proposed method is demonstrated by a set of benchmark cases.
Factors influencing social commerce adoption in Mexico: An empirical research

Resumen Las redes sociales han cambiado las estructuras de poder en el mercado y han abierto oportunidades para nuevos modelos de negocios de comercio electronico, tales como comercio social. Esta investigacion tiene como objetivo identificar factores relacionados con el comportamiento de los consumidores mexicanos en los sitios de redes sociales. Especificamente, prueba la influencia del apoyo emocional e informativo; la confianza hacia la red social y contactos en la red social; la influencia de la familia y los amigos; y vender la reputacion de la empresa en la intencion de compra. El modelo se probo mediante analisis factorial confirmatorio y se verifico mediante ecuaciones estructurales. El modelo predice que el comportamiento de compra de los consumidores mexicanos en los sitios de la red esta influenciado por la confianza hacia los amigos de SNS, eWOM de los amigos de SNS y la reputacion del sitio de s-commerce
Learning disability and work inclusion: on the experiences, aspirations and empowerment of sheltered employment workers in Norway

Abstract This inclusive research inspired study explored the experiences of people with learning disabilities working in a Norwegian sheltered employment company. The study aimed at developing knowledge on the working experiences of people with learning disabilities and the impact of their participation in the study. We employed focus groups, supplemented by informal discussions to generate data for the study. Together with the employees and employers, we established two three-member focus groups. The participants, both males and females, discussed their work experiences and the empowering consequences of participating in the research. The data indicated that the employees had desires to work fully in ordinary companies, assuming socially valued roles. The participants experienced a combination of work in ordinary and sheltered employment companies as less stressful and satisfying. The adopted inclusive research strategy empowered our research partners to reflect on their experiences and made efforts to meet their working life dreams. Points of interest Participation in work-life is a central policy for all Norwegian citizens, including people with learning disabilities. This article presents and discusses the personal experiences of people with learning disabilities whose desire it is to work and contribute their quota to the Norwegian society. The research participants indicated that many people with learning disabilities would like to be a part of ordinary working life, but face barriers to attaining their goals. A combination of sheltered and ordinary work seems to work well for research participants with learning disabilities. Participation in this inclusive research seemed to empower people with learning disabilities and enabled them to realize their dreams and aspiration regarding work-life.
High-Bandwidth Spatial Equalization for mmWave Massive MU-MIMO With Processing-in-Memory

All-digital basestation (BS) architectures enable superior spectral efficiency compared to hybrid solutions in massive multi-user MIMO systems. However, supporting large bandwidths with all-digital architectures at mmWave frequencies is challenging as traditional baseband processing would result in excessively high power consumption and large silicon area. The recently-proposed concept of finite-alphabet equalization is able to address both of these issues by using equalization matrices that contain low-resolution entries to lower the power and complexity of high-throughput matrix-vector products in hardware. In this brief, we explore two different finite-alphabet equalization hardware implementations that tightly integrate the memory and processing elements: (i) a parallel array of multiply-accumulate (MAC) units and (ii) a bit-serial processing-in-memory (PIM) architecture. Our all-digital VLSI implementation results in 28nm CMOS show that the bit-serial PIM architecture reduces the area and power consumption up to a factor of <inline-formula> <tex-math notation="LaTeX">$ 2\times $ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$3\times $ </tex-math></inline-formula>, respectively, when compared to a parallel MAC array that operates at the same throughput.
How Well Do Schools Mix Students from Different Neighborhoods? School Segregation and Residential Segregation in Swedish Municipalities

doi: 10.1111/gean.12233 © 2020 The Authors. Geographical Analysis published by Wiley Periodicals, Inc. on behalf of The Ohio State University This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. 1 How Well Do Schools Mix Students from Different Neighborhoods? School Segregation and Residential Segregation in Swedish Municipalities
BREAST CYTOPATHOLOGY REPORTING USING THE NEWLY PROPOSED IAC
YOKOHAMA SYSTEM: A SINGLE INSTITUTIONAL RETROSPECTIVE STUDY OF
THE APPLICATION OF THE SYSTEM AND UTILITY OF BREAST FNAC.

INTRODUCTION Breast carcinoma is common cancer in females in developing and developed countries. Breast cancer has ranked number one cancer among Indian females with age adjusted rate as high as 25.8 per 100,000 women and mortality of 12.7 per 100,000 women (1). There is a signicant increase in the incidence and cancer-associated morbidity and mortality in Indian subcontinent as described in global and Indian studies (2-5). The lower breast cancer survival rates are associatedwith lack of early detection programs, advanced stage of disease at the time of presentation, lack of functional diagnostic and treatment facilities and limited accessibility to professional care (6).
Endeavor Agility on Consumption Value through Affirming an Acceptable Degree of Utilization Esteem for New Items

Purpose: This comparative study holistically assesses the agility that turns into the standard of business and methods for progress. Design/Methodology/Approach: The contribution and the relevant methodology based on a duality of purposes. They are (i) quantitative research system that utilized to complete the investigation and (ii) both fundamental and auxiliary sources used to assemble information. Findings: Based on the holistically implied arguments and yielded results, it proposed that the writing audit results various parameters to clarify nimbleness and utilization esteems, which utilized to build a survey. At that point, the examination led to design a fitting example between use esteems and hidden agility measurements. Practical implications: Addressing to dual purposes, this study sheds new light on the Mall-intercept method block strategy that utilized to gather reactions. Originality/Value: Although this study organically builds upon recent studies, this area gives a detail examination of the investigation. The survey has a field containing the segment profile of the respondents. This examination applies the utilization esteem model as the essential system, which incorporated the practical worth, the social worth, the passionate worth, the epistemic worth, and the restrictive worth.