Miracle-dz/UniFAR-FTUs huggingface dataset:
μ-Lat: A Mouse Model to Evaluate Human Immunodeficiency Virus Eradication Strategies

A critical barrier to the development of a human immunodeficiency virus (HIV) cure is the lack of a scalable animal model that enables robust evaluation of eradication approaches prior to testing in humans. We established a humanized mouse model of latent HIV infection by transplanting “J-Lat” cells, Jurkat cells harboring a latent HIV provirus encoding an enhanced green fluorescent protein (GFP) reporter, into irradiated adult NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice. J-Lat cells exhibited successful engraftment in several tissues including spleen, bone barrow, peripheral blood, and lung, in line with the diverse natural tissue tropism of HIV. Administration of tumor necrosis factor (TNF)-α, an established HIV latency reversal agent, significantly induced GFP expression in engrafted cells across tissues, reflecting viral reactivation. These data suggest that our murine latency (“μ-Lat”) model enables efficient determination of how effectively viral eradication agents, including latency reversal agents, penetrate and function in diverse anatomical sites harboring HIV in vivo.
Design of D-Band Transformer-Based Gain-Boosting Class-AB Power Amplifiers in Silicon Technologies

This paper presents design considerations and methodology for D-band transformer-based Class-AB gain-boosting power amplifiers (PAs) in three advanced silicon technologies: 28 nm bulk CMOS (complementary metal oxide semiconductor), 22 nm FD-SOI (fully-depleted silicon on insulator), and 130 nm SiGe BiCMOS (Silicon-germanium bipolar-CMOS). Firstly, the choice of processes and models together with de-embedding approaches are discussed and described. Then, a general design flow for a transformer-based matching network (TMN) is introduced to accelerate the design of multistage PAs. Further, two gain-boosting topologies are analyzed. The influence of capacitive gain-boosting on PA performance (maximum available power gain <inline-formula> <tex-math notation="LaTeX">$G_{max}$ </tex-math></inline-formula>, saturation power <inline-formula> <tex-math notation="LaTeX">$P_{sat}$ </tex-math></inline-formula>, drain efficiency DE and power-added efficiency PAE) is studied for different silicon technologies after properly sizing the PA transistors to reach an optimum load resistance <inline-formula> <tex-math notation="LaTeX">$R_{opt}$ </tex-math></inline-formula>. The inductive gain-boosting PA is explored and compared with the capacitive gain-boosting one in SiGe BiCMOS to achieve an even higher <inline-formula> <tex-math notation="LaTeX">$P_{sat}$ </tex-math></inline-formula> while maintaining a high <inline-formula> <tex-math notation="LaTeX">$G_{max}$ </tex-math></inline-formula>. Finally, A D-band 4-stage capacitive gain-boosting PA is fabricated in a 28 nm bulk CMOS process as a reference to verify the design methodology and simulation results, and its detailed design considerations are described. This prototyped D-band PA achieved the state-of-the-art results: a 22.5 dB <inline-formula> <tex-math notation="LaTeX">$G_{p}$ </tex-math></inline-formula>, 6.6 % PAE, 8 dBm <inline-formula> <tex-math notation="LaTeX">$P_{sat}$ </tex-math></inline-formula> and 81.1 FoM with only 0.0265 mm<sup>2</sup> core area.
MMSE One-Bit Precoding for MU-MIMO Systems With Enhanced Receive Processing

One-bit precoding is a recently proposed scheme that enables significant savings in hardware cost and power consumption for massive multiuser multiple-input–multiple-output systems. In this letter, a new minimum mean-square-error (MMSE) precoder is presented for both single- and multiple-antenna mobile stations with enhanced receive processing (ERP) capability. By exploiting the structure embedded in the formulated nonconvex optimization problem, a new algorithm is developed on the basis of a combination of the alternating minimization method and mathematical programming with equilibrium constraints. An approximate maximum likelihood detector is also proposed to collaborate with the MMSE-ERP precoder. Simulation results verify that our MMSE-ERP precoder can exploit the additional degrees of freedom in the general system model considered, resulting in significant performance gain compared with existing one-bit precoders.
HUBUNGAN ANTARA PARITAS DENGAN KEJADIAN RUPTURE PERINEUM

Rupture of the perineum is a rupture that occurs in the perineum almost in all first labor and not infrequently in subsequent labor. Based on data obtained in Puskesmas Batulicin 1 recorded as many as 351 maternity mothers and rine perineum incidence amounted to 165 people which is the highest case during 2016. Parity is a woman who had given birth to a baby alive and dead. This study was conducted to determine the relationship between parity with the incidence of perineal rupture in maternal mothers, this study was conducted to prove whether there is a relationship between parity with rupture perineum events. This research use analytical survey method by using cross sectional approach. The population in this study were all maternal mothers recorded at Puskesmas Batulicin 1 Kabupaten Tanah Bumbu. Data analysis was done by Chisquare test (P = 0,05). The data obtained were analyzed using chi-square test with significance of 0.05. Chi-Square test results obtained (P = 0,009) there is a close relationship between parity with rupture perineum events. The conclusion of this study was found to have a close relationship between maternal parity with the incidence of perineum rupture in Puskesmas Batulicin 1 Kabupaten Tanah Bumbu. It is expected that maternity mothers will increase their knowledge of good and right way of pushing.
Modeling the Outbreak of an Infectious Disease on a Heterogeneous Network

The outbreak of infectious diseases is a global public health threat for the international community. Modelling the propagation of epidemics in a society is one of the important fields in epidemiology science. It is essential to know the number of infected cases for estimating and controlling the spread of disease in the affected countries. In this study, we used complex network theory to model the spread mechanism of epidemic disease in social networks. We modeled a social complex network by graph theory. Individuals are considered as nodes and acquaintances between them are considered as links. Disease virus can transmit along the links between nodes (people) according to different situations. In this work, we proposed a dynamic model for simulating the outbreak of infectious disease on a social network based on the susceptible, exposed, infected and recovered (SEIR) dynamical categories. It has been tried to study the heterogeneity on the network by considering two key factors in the epidemic propagation: 1) The communications weights between individuals in the network 2) different body resistances of people based on age. The proposed dynamic model was applied on a real social network which was constructed in our previous research. We compared the proposed model with two different dynamic models. Finally, the simulations were compared with the reported data of infected cases of SARS outbreak in Hong Kong in 2003. The results indicated some similarity between our proposed model and the real reported data. Based on the results, it could be concluded that considering communications weights and body resistances of people captures the dynamic of disease spread in a proper way.
A Phase 3 Randomized, Double-blind, Multi-center Study to Compare the Safety and Efficacy of IV to Oral Omadacycline to Moxifloxacin for the Treatment of Adult Subjects with CABP (The OPTIC Study)

FUNDING AND DISCLOSURES BACKGROUND METHODS A Phase 3, Randomized, Double-Blind, Multi-Center Study to Compare the Safety and Efficacy of IV to Oral Omadacycline to Moxifloxacin for the Treatment of Adult Patients With CABP (The OPTIC Study) Roman Stets, MD, PhD1; Monica Popescu, MD2; Joven Gonong, MD3; Ismail Mitha, MD4; William Nseir, MD5; Andrzej Madej, MD, PhD6; Courtney Kirsch, BS7; Anita Das, PhD7; Lynne Garrity-Ryan, PhD7; Judith N. Steenbergen, PhD7; Amy Manley, BS7; Paul B. Eckburg, MD7; Stephen Villano, MD7; Evan Tzanis, BA7; Paul McGovern, MD7; Evan Loh, MD7 Poster 1883
Integrated Financial Management Information System: a conceptual framework for Migori County, Kenya

In the modern world, developing countries like Kenya, Tanzania, Ethiopia and several others in the African continent have been encouraged to reform their public expenditure management systems through computerization of the entire public sectors in response to the increasing volume of data or information that need to be processed. There are, however, various factors to be considered prior to the implementation of the public expenditure management information systems. This paper undertakes a theoretical review of the critical success factors that impact on the implementation of an Integrated Financial Management Information System (IFMIS) with a view to identify factors applicable to the Migori County of Kenya. The paper, then, identifies the key factors to be incorporated in the proposed IFMS framework. The proposed framework draws from the Technology Acceptance Model (TAM), Innovation Diffusion Theory (IDT) and the Work Around Theory (WAT). The paper fuses these theories towards a successful adoption of use of modern technology within the public sector IFMS. The key factors include technical, organizational, environmental, cultural and ethical behavior. These factors could improve efficiency and transparency through direct payments to suppliers and contractors, reduced prices due to gains based on the time value of money, as well as the comparative analysis of market rates and advanced relations across the numerous organizational units within government on execution, reporting, and thoroughness of budget transactions.
New perspectives in assisted reproductive technologies in cattle

The use of assisted reproductive technologies in cattle is been increasing in the past few years. Fixed-timed artificial insemination (FTAI) procedures are responsible for 85% of all artificial insemination (AI) done in Brazil. Despite the numbers of in vivo derived (IVD) embryos tended to decrease in the last 10 years, in vitro production (IVP) of embryos has increased significantly, with more than 57% of all IVP embryos in the world produced in Brazil. These biotechnologies have helped to substantially improve reproductive efficiency in beef and dairy cattle. In relation to embryo transfer, production of in vivo derived (IVD) embryos remained relatively stable, with average production of 30-40,000 embryos per year, whereas in vitro production (IVP) of embryos had a substantial increase, from about 12,500 IVP embryos in 2000 to more than 300,000 IVP embryos after 2010. Inside this picture, FTAI remains growing for both, dairy and beef cattle, although, there are new possibilities to get even better efficiency. The use of GnRH and new approaches to help this efficiency were reported recently. In addition, there is much more room for improvement in other reproductive technologies, since there are several reports of high pregnancy loss and high peripartum loss, when IVP embryos are used, and even more dramatic for cloning. This review aims to update the readers with new data regarding assisted reproductive technologies.
Effects of High Flux versus Low Flux on Serum C-Reactive Protein A as an Inflammatory Biomarker in Hemodialysis Patients

Background: Traditional low-flux dialysis cannot improve micro-inflammatory status, while new high-flux dialysis can improve the micro-inflammation and lipid metabolism, it helps to improve the quality of life and survival rate of patients, so how to improve the micro-inflammatory status are a focus for researchers. Objective: was to observe the effect of high flux hemodialysis (HFHD) with Gambro polyflux 170H dialyser and low flux hemodialysis (LFPD) with polyflux 17L dialyser on high-sensitivity C-reactive protein in patients with maintenance hemodialysis. Methods: 60 patients with maintenance hemodialysis were randomly divided into HFHD group and LFHD group. Another 20 cases for physical examinations served as normal control group. The maintenance hemodialysis patients were treated with HFHD using 170H dialyser dliahyser and LFHD using 17L dialyser, three times per week, 4 hours once. After 6 months of the treatment, high-sensitive C-reactive protein was determined in patients as well as normal controls before and after treatment. Results and Conclusion: in two groups, the levels of high-sensitive C-reactive protein before the treatment were higher than normal control (P <0.001). In HFHD group, serum high-sensitive C-reactive protein markedly decreased (P <0.01). In LFHD group, these indices remained unchanged after the dialysis for 6 months. HFHD with 170H polysulfone dialyser is effective in improving micro-inflammation in maintained hemodialysis patients.
Modeling the outlet temperature in heat exchangers: Case study

This article presents the results of the study of the heat transfer in a heat exchanger where the working fluid is the crude oil prepared for desalination, and the thermic agent is the recirculating heavy gasoline fraction. Firstly, the Reynolds numbers have been computed using the temperatures and flow rates of the fluids as input variables. Then, General Regression Neural Network and Multilayer Perceptron (MLP) were used for the outlet temperatures estimation using the inlet temperatures and the Reynolds numbers as input variables. The best models on the training dataset were obtained utilizing a MLP with one hidden layer, while the best performance on the validation dataset was obtained using a MLP network with two hidden layers
Measurement of Individual Dose from External Exposure among All Citizens of Date City 5 to 51 Months after the Fukushima NPP Accident: Prediction of Lifetime Additional Dose and Evaluating the Effect of Decontamination on Individual Dose

In the first paper of this series, we showed that the ratio c of individual dose to ambient dose did not change with time in Date City, Fukushima Prefecture, after the Fukushima Daiichi Nuclear Power Plant accident. The purpose of the present paper, the second in a series, is to estimate the lifetime doses of the Date City residents, based on continuous glass badge monitoring data, extrapolated by means of the ambient-dose-rate reduction function obtained from the airborne monitoring data. As a result, we found that the mean additional lifetime dose of residents living in Date City is not expected to exceed 18 mSv. In addition, effects of decontamination on the reduction of individual doses were not evident. This method of combining individual doses and the ambient doses, as developed in this study, has made it possible to predict with reasonable certainty the lifetime doses of residents who continue to live in this radiologically contaminated area.
A Novel Feature Maps Covariance Minimization Approach for Advancing Convolutional Neural Network Performance

We present a method for boosting the performance of the Convolutional Neural Network (CNN) by reducing the covariance between the feature maps of the convolutional layers. In a CNN, the units of a hidden layer are segmented into the feature/activation maps. The units within a feature map share the weight matrix (filter), or in simple terms look for the same feature. A feature map is the output of one filter applied to the previous layer. CNN search for features such as straight lines, and as these features are spotted, they get reported to the feature map. During the learning process, the convolutional neural network defines what it perceives as important. Each feature map is looking for something else: one feature map could be looking for horizontal lines while the other for vertical lines or curves. Reducing the covariance between the feature maps of a convolutional layer maximizes the variance between the feature maps out of that layer. This supplements the decrement in the redundancy of the feature maps and consequently maximizes the information represented by the feature maps.
Using the life course approach to explain the onset and continuity of preventive health-care behaviors: A comparative study across four countries

ABSTRACT The objective of this research is to examine the factors that promote the onset and continuity of preventive health-care behaviors over the course of one’s life. Using the life course paradigm as an overarching conceptual framework, hypotheses are developed that relate to the role of life events that trigger processes responsible for the initiation and discontinuation of three preventive health-care behaviors: exercising, using dietary supplements or vitamins, and having regular physical exams. The samples used are drawn from the United States, Thailand, South Korea, and Brazil. Results suggest that experience of life events and consequential life-course adaptation processes (socialization, stress and coping, and human development) are important predictors of initiation and discontinuation of preventive health-care behaviors. The relative influence of these explanatory variables varies across cultures, suggesting the importance of contextual factors in explaining preventive health-care behaviors. Implications for further research are also suggested.
Translation and Validation of EORTC QLQ-PR25 Questionnaire for Assessing Quality of Life of Prostate Cancer Patients in a Moroccan Population

Understanding the effects of prostate cancer on quality of life of affected patients is essential for clinical research and also for optimal management and care. The main objective of this study was to evaluate the psychometric properties of a Moroccan dialect version of the quality of life questionnaire (EORTC QLQ-PR25). The study was conducted among patients with prostate cancer in oncology department of the Ibn Rochd University Hospital Mohammed VI Center for cancers treatment in Casablanca during the period of study (from January to December 2017). Statistical analysis data was done using R software. Internal consistency was tested using Cronbach’s alpha. A total of 82 subjects were included, the mean age of patients was 69.6 years with a standard deviation of 7.9 years. The majority of them were illiterate, with 59.8%, and urban people about 60%. Good reliability was revealed for the Moroccan dialect version with Cronbach’s alpha coefficient ranging from 0.17 for “sexual function” dimension to 0.83 for “urinary symptoms” dimension. Reproducibility of the scale was good with intra-class correlation coefficients ranging from 0.69 for “sexual function” dimension to 0.87 for “urinary symptoms” dimension. Scale reproducibility was good with intra-class correlation coefficients ranging from 0.69 for “sexual function” dimension to 0.87 for “urinary symptoms” dimension. Dialectal version obtained showed good reliability for the dimension “urinary symptoms” and acceptable for other dimensions except for “sexual function” which was not satisfactory.
Gold Nanoparticles to Tackle Drug Resistance in Cancer

IX LIST OF PUBLICATIONS . XI LIST OF ABBREVIATIONS . XIII TABLE OF CONTENTS . XV LIST OF FIGURES . XIX LIST OF TABLES . XXIII LIST OF EQUATIONS . XXV CHAPTER 1 – INTRODUCTION . 1 1.1 CANCER . 2 1.2 CANCER PROGRESSION . 3 1.2. 1 Sustaining proliferative signalling . 4 1.2. 2 Evading growth suppressors . 5 1.2. 3 Evading programmed cell death . 5 1.2. 4 Enabling replicative immortality . 5 1.2. 5 Tumour microenvironment and energy metabolism . 6 1.2. 6 Inducing angiogenesis . 7 1.2. 7 Evading the immune system . 8 1.2. 8 Activating Invasion and Metastasis . 9 1.3 DIFFERENT TYPES OF COLORECTAL, LUNG AND BREAST CANCER . 10 1.4 CANCER THERAPY . 12 1.4. 1 Surgery . 12 1.4. 2 Radiotherapy . 12 1.4. 3 Chemotherapy . 13 1.4. 4 Immunotherapy. 16 1.4. 5 Gene therapy . 17 1.4. 6 Thermal therapy . 19 1.5 CANCER RESISTANCE TO TREATMENT . 20 1.6 NANOMEDICINE . 22 1.6. 1 Gold Nanoparticles . 24 1.6. 2 Targeting and Delivery . 26 1.6. 3 Therapeutic Agents . 28 1.6. 4 Phototherapy . 30
Array‐Based Iterative Measurements of 
 SmKS Travel Times and Their Constraints on Outermost Core Structure

Vigorous convection in Earth's outer core led to the suggestion that it is chemically homogeneous. However, there is increasing seismic evidence for structural complexities close to the outer core's upper and lower boundaries. Both body waves and normal mode data have been used to estimate a P wave velocity, Vp , at the top of the outer core (the E′ layer), which is lower than that in the Preliminary Reference Earth Model. However, these low Vp models do not agree on the form of this velocity anomaly. One reason for this is the difficulty in retrieving and measuring SmKS arrival times. To address this issue, we propose a novel approach using data from seismic arrays to iteratively measure SmKS ‐ SKKS differential travel times. This approach extracts individual SmKS signal from mixed waveforms of the SmKS series, allowing us to reliably measure differential travel times. We successfully use this method to measure SmKS time delays from earthquakes in the Fiji‐Tonga and Vanuatu subduction zones. SmKS time delays are measured by waveform cross correlation between SmKS and SKKS , and the cross‐correlation coefficient allows us to access measurement quality. We also apply this iterative scheme to synthetic SmKS seismograms to investigate the 3‐D mantle structure's effects. The mantle structure corrections are not negligible for our data, and neglecting them could bias the Vp estimation of uppermost outer core. After mantle structure corrections, we can still see substantial time delays of S3KS , S4KS , and S5KS , supporting a low Vp at the top of Earth's outer core.
Investigation of fatigue strength of aluminium 2024-T3 subjected to shot peening process by Ni shots

Aluminium alloys are most suitable for light weight applications. This research paper investigates the fatigue strength of Aluminium alloy 2024-T3 after shot peeing process using nickel shots. Nickel shots are used in this research to investigate the influence of nickel on the fatigue strength of aluminum 2024-T3 alloy. Compressed air is used for shot peening process. Shot peening process parameter values are chosen based on response surface method (RSM) to conduct the experiments. Desirability approach is used to get the optimized values of process parameters. High cycle fatigue testing is performed to find the fatigue strength of specimens before and after shot peening process. An increase in the fatigue strength up to 34% is observed after peening using the nickel shots. FESEM and EDS tests revealed the presence of nickel on the surface of aluminium 2024-T3 specimen after shot penning with nickel shots.
New basic unit and cascaded multilevel inverters with reduced power electronic devices

ABSTRACT In this paper, a new cascade multilevel inverter based on series connection of several basic units is proposed. The basic topology consists of 5 dc voltage sources and 12 switches. The required mathematical analysis consisting of voltage on switches, power losses and the values of dc voltage sources is provided. To verify the advantages of proposed topology, the suggested structure is compared with other multilevel inverter topologies in terms of used dc voltage sources, switches, voltage on switches and the number of on-state switches. The proposed structure uses the least numbers of dc voltage sources and switches compared to other multilevel inverters for the same number of levels. Also, voltage rating on the switches in the proposed topology is less than other topologies. These characteristics cause the weight, size and cost of proposed topology to be reduced. The proposed inverter is implemented using experimental setup. The experimental results verify the performance of proposed structure.