Miracle-dz/UniFAR-FTUs huggingface dataset:
Homology modelling, virtual screening and molecular dynamics of the MARK3 KA1 domain for cancer drug design

Structural homology modelling was done with the software AMPS, MODELLER, PROCHECK, WHATIF AND VERIFY-3D to generate a quality model of human MARK3. Macromolecular docking simulations seem to confirm recent data in the literature and in MARK3 there does not occur intramolecular interactions between the associated kinase domain KA1 and the catalytic domain. Using virtual screening, we were able to identify and suggest the principal residues of MARK3 which interact with the ligands in addition to those reported in the literature. The pharmacophoric model obtained from Discovery Studio coincides with those obtained by molecular interaction fields, indicating the principal ligand residues of the MARK3 KA1 domain. Using virtual screening with pharmacophoric constraints as well as molecular dynamics, the most stable compounds in the ligand site as well as their potential toxicities were used to select potential inhibitors for further in vitro and in vivo investigations of human MARK3 KA1 domain, which could eventually pass to the market to be used for the treatment of head and neck cancer.
Professionalism in extensive sheep farming system in Central Greece

Yiakoulaki, M. , & Hasanagas, N. (2019). Professionalism in extensive sheep farming system in Central Greece. Bulgarian Journal of Agricultural Science, 25(4), 661–667 Aim of this paper is to explore determinants and conditions of professionalism in extensive sheep breeding system. Professionalism is here defi ned as considering extensive sheep breeding as a “main occupation” according to the self-assessment of breeders. The study was conducted in Central Greece using in-depth interviews and standardized questionnaires answered by the whole population of sheep breeders (Ν = 60). The data was processed by using Kendall test (P ≤ 0.05). It has been found that professionalism is related to the location of stables outside the residential areas (-0.409), the milk-based income (0.216), the annual duration of milk production (0.277) and the existence of milk storage system (0.272). Personal characteristics of sheep breeders, structural features of the holding, usage of forage resources, feedstuffs and grasslands’ infrastructure are not strong determinants of professionalism. The novelty of the content consists in the exploration of professionalism as a self-perception of the breeders, which is considered to be more authentic than any arbitrary defi nition of professionalism and the new information provided by this research lies in pointing out that the breeders’ perception of professionalism can be characterized as superfi cial and entrepreneurially unsustainable, because it is related with the production output and not with deep-rooted prerequisites like structure and conditions. Policy instruments for strengthening professionalism are suggested.
INDIRECT SOMATIC EMBRYOGENESIS ON MUTANTS OF Agave tequilana WEBER CULTIVAR BLUE INDUCED WITH CO GAMMA RAYS† [EMBRIOGÉNESIS SOMÁTICA INDIRECTA EN MUTANTES DE Agave tequilana WEBER VAR. AZUL INDUCIDOS CON RAYOS GAMMA CO]

1Centro Universitario de Ciencias Biológicas y Agropecuarias. Universidad de Guadalajara. Camino Ramón Padilla Sánchez No. 2100 Nextipac C.P. 51100. Zapopan, Jalisco, México. Teléfono: 52 33 3777 1160 Fax: 52 33 3777 1150, Emails. Carlos.rserrano@academicos.udg. mx; gil.vcalleros@academicos.udg. mx; enrique.pimienta@academicos.udg. mx; eduardo.rguzman@academicos.udg. mx; aangeles_1305@hotmail.com 2 Centro Universitario de la Ciénega. Universidad de Guadalajara. Av. Universidad 1115, Ocotlán, Jalisco, México. CP 47820. Email. botin77@gmail.com; *Corresponding author
Über Schichtenfiltration, ein Beitrag zur Theorie der Gasmaske

32. In der vorliegenden Abhandlung werden die Ergebnisse einer von N. Schilow, Lidie Lepin und S. Wosnessensky ausgefuhrten Untersuchung uber die Absorption von Chlor aus einem chlorhaltigen Luftstrom durch eine Schicht aktiver Kohle vom Standpunkte der in Aussig entwickelten Theorie der Gasmaske einer eingehenden Betrachtung unterzogen, und es wird gezeigt, das sich die Gesamtheit der unter Variation der Lange der absorbierenden Kohleschicht, der Starke des Luftstromes, der Konzentration des Chlors in der Luft und der Korngrose der Kohle von den genannten Autoren erhaltenen Ergebnisse durch die Aussiger Theorie einheitlich zusammenfassen lassen.
European Journal of Social Sciences Studies-ISSN 2501-8590

The present research examined the relationship between parenting practices and children's characteristics. Specifically, the study focused on the children's characteristics, such as age, gender, birth order, and family structure, which influence parenting practices and have an impact on children's family relations, school performance, social competence, and children's self-esteem. The sample consisted of 336 Greek-speaking parents who had children age six up to twelve years old. Most of the participating parents were mothers (77%), with an average age of 35,7 +5,18. A large majority of the participants (75%) were a part of two parents-family, and 25% were a one parent-family. Parents answered four self-report questionnaires: Α Personal Information Form (PIF) was used to collect information about family and children's characteristics, the Parental Acceptance-Rejection Questionnaire (PARQ-mother and father version), the Parental Authority Styles (PAQ) Questionnaire and the Children's Family Relations, School Performance, Social Competence, and Self-Esteem Questionnaire. Research results showed that children's characteristics (gender, age, and birth order) are significantly related to parents' parenting styles. Furthermore, the family structure (one or two parents family) was statistically significant in parenting practices. As a result, parenting practices affected children's family relations, social competence, school performance, and self-esteem.
Non-Suicidal Self-Injury in Those Dealing With Borderline Personality Disorder or Separation from Parents

Non-suicidal self-injury (NSSI) is a deliberate destruction of one’s own body tissue without suicidal intention that causes physical injury. NSSI is mostly found in adolescents or young adults (Paul, Tsypes, Eidlitz, Ernhout, & Whitlock, 2015). Borderline personality disorder (BPD) is one of the risk factors for developing NSSI. Individuals with borderline personality disorder also experience invalidation during their childhood, this can cause individuals with BPD to feel that they deserve to receive NSSI as a form of self-punishment (Sadeh et al., 2014). In addition, children who experience parental separation (through death, divorce or employment) have a higher risk factor for developing NSSI (Astrup, Pedersen, Mok, Carr, & Webb, 2017). A literature search was conducted in six databases, and a total of 20 relevant articles were found. The explanation of the relationship between non-suicidal self-injury, borderline personality disorder, and loss of or separation from a parent are explored in this study, in order to increase understanding of how NSSI behaviours can be prevented. Keywords: NSSI, Borderline Personality, Separation Parent
Iris from the ground up

Iris is a framework for higher-order concurrent separation logic, which has been implemented in the Coq proof assistant and deployed very effectively in a wide variety of verification projects. Iris was designed with the express goal of simplifying and consolidating the foundations of modern separation logics, but it has evolved over time, and the design and semantic foundations of Iris itself have yet to be fully written down and explained together properly in one place. Here, we attempt to fill this gap, presenting a reasonably complete picture of the latest version of Iris (version 3.1), from first principles and in one coherent narrative.
Self-assembly of the symmetric diblock copolymer in a confined state: Monte Carlo simulation

Self-assembly of symmetric diblock copolymers in confined state has been investigated by means of Monte Carlo simulation method. The symmetric diblock copolymers were confined in two- (parallel walls or circle) or in three-dimensional (spherical or cylindrical) space. There are interactions between these boundaries and the symmetric diblock polymers. These interactions and boundary shape resulted in the formation of novel self-assemble structures, e.g., strip, circle, core-multishell, and multibarrel-layer structures. Simulation results predicated that it is possible to design different phase structures for block copolymers by adjusting boundary shape and boundary-block copolymer interactions.
POWER IN INDONESIAN PRESIDENTIAL SPEECHES: AN ANALYSIS OF LINGUISTIC MODALITY

This paper discusses the relationship between the language and power in the presidential speech text, which is projected through linguistic features, especially modalities. The data was obtained from a speech delivered by President Joko Widodo during the plenary session of the Indonesian People's Consultative Assembly (MPR RI) for the inauguration of the elected president for the 2019-2024 period and the delivery of the president's vision for Indonesia better. Analysis of this paper from linguisti c modalities uses a three-dimensional model of Fairclough's critical discourse (CDA) analysis to answer its research questions. The results show that Jokowi used several linguistic modal verbs in projecting his strength. Based on the modality's context, it can be understood that the president conveyed his strategic desire to be himself when he tried to connect with the audience and build his image, audience, and relationship. The President produces a discourse that embodies assumptions about his leadership and audience's social relationship and affirms his legal authority as president and his power. Through the language used, Jokowi creates, maintains, and explains power he holds in these forums.
Grand Challenges in Immersive Analytics

Immersive Analytics is a quickly evolving field that unites several areas such as visualisation, immersive environments, and human-computer interaction to support human data analysis with emerging technologies. This research has thrived over the past years with multiple workshops, seminars, and a growing body of publications, spanning several conferences. Given the rapid advancement of interaction technologies and novel application domains, this paper aims toward a broader research agenda to enable widespread adoption. We present 17 key research challenges developed over multiple sessions by a diverse group of 24 international experts, initiated from a virtual scientific workshop at ACM CHI 2020. These challenges aim to coordinate future work by providing a systematic roadmap of current directions and impending hurdles to facilitate productive and effective applications for Immersive Analytics.
Ensemble and Individual Characterization of the Nonlinear Optical Properties of ZnO and BaTiO3 Nanocrystals

Hyper Rayleigh scattering (HRS) and second harmonic (SH) microscopy were used to study the second order nonlinear optical response of ZnO and BaTiO3 nanocrystals, which have been recently proposed as new markers for bioimaging. HRS, combined with dynamic light scattering, was first used to retrieve hyperpolarizabilities and nonlinear coefficients of both type of nanocrystals. The results indicate that the main contribution to the SH signal is related to the bulk noncentrosymmetric structure of the particles. Successively, we carried out the inspection of individual nanocrystals by SH microscopy, interpreting their response using the nonlinear coefficients deduced from HRS.
Cohesive Devices in Student’s Writing (A Discourse Analysis on Argumentative Text)

This research aims to analyse a piece of argumentative writing produced by fifth semester of Darussunnah students in a term of cohesion issues of discourse analysis. The cohesive devices are viewed as a structure of analysis to investigate the grammatical and lexical cohesion in writing. Qualitative and quantitative (mixed method) were applied in analysing the data. The quantitative analysis investigates the frequency and percentage of errors committed in student’s writing. Qualitative analysis were employed to investigate linguistic description and the explanation of the cohesion produced by student’s writing. The result showed that students have performed the cohesive devices. However, students need to improve the use of cohesive device, especially in grammatical cohesion to result higher level of cohesion.
The Dynamic Freight Routing Problem for Less-Than-Truckload Carriers

Less-than-truckload (LTL) carriers transport freight shipments from origins to destinations by consolidating freight using a network of terminals. As daily freight quantities are uncertain, carriers dynamically decide freight routes on the day of operations. We introduce the dynamic freight routing problem (DFRP) and model this problem as a Markov decision process (MDP). To overcome the curses of dimensionality of the MDP model, we introduce an approximate dynamic programming (ADP) solution approach that uses a lookup table to store value function approximations and present and compares a number of aggregation approaches that use features of the postdecision states (PDSs) to aggregate the PDS space and reduce the number of entries in the lookup table. Furthermore, because the decision subproblems are integer programs (IPs), we present a framework for integrating lookup tables into the decision subproblem IPs. This framework consists of (1) a modeling approach for the integration of lookup table value function approximations into subproblem IPs to form extended subproblem IPs; (2) a solution approach, PDS-IP-bounding, which decomposes the extended subproblem IPs into many smaller IPs and uses dynamic bounds to reduce the number of small IPs that have to be solved; and (3) an adaptation of the ϵ-greedy exploration-exploitation algorithm for the IP setting. Our computational experiments show that despite the DFRP having high-dimensional PDS vectors, a two-dimensional aggregation of the space can produce policies that outperform standard myopic policies. Moreover, they demonstrate that the PDS-IP-bounding algorithm provides computational advantages over solving the extended subproblem IPs using a commercial solver. Funding: A. Baubaid acknowledges financial support from the King Fahd University of Petroleum & Minerals. Supplemental Material: The online appendices are available at https://doi.org/10.1287/trsc.2022. 1190 .
SESCF: A Secure and Efficient Supply Chain Framework via Blockchain-Based Smart Contracts

+e demands for the fairness, security, and efficiency of the supply chain have grown significantly due to the rise of globalization. However, some problems of the information flow, logistics, and capital flow in the supply chain remain a challenge, such as the information asymmetry between upstream and downstream, substandard quality of goods, difficulty in traceability, and default of payment. +erefore, this paper proposes a blockchain-based supply chain framework (SESCF), which solves the supply chain problems securely and efficiently. First, the use of blockchain and smart contracts ensures the information symmetry in the supply chain system. Second, the radio frequency identification (RFID) provides a unique identity of goods, which helps in real-time quality monitoring. Additionally, the immutability and distributed storage of the blockchain play an important role in tracking the origin of goods. +ird, the efficient payment channel is used to solve the problem of payment defaults. Furthermore, simulations of smart contracts along with the security analyses are presented in this paper. We also implement a blockchain-based supply chain system (SescfDapp), which is built upon a Consortium blockchain. Large-scale experiments and detailed analysis prove the feasibility and efficiency of our proposed system.
Multimodal Cocktail Periarticular Injection vs Femoral Nerve Block After Total Knee Arthroplasty: A Simultaneous Bilateral Randomized Study

Background Pain control after total knee arthroplasty (TKA) is important for early postoperative experience and knee rehabilitation. However, there is no consensus on the Pain management after TKA. Whether early analgesic effect and patient satisfaction can reach or even exceed the femoral nerve block has been controversial. The aim of our study was to compare the early analgesia effect with multimodal cocktail periarticular injection (MCPI) and Femoral nerve block (FNB) during simultaneous knee arthroplasty. Methods Our study was a prospective randomized, double-blind controlled trial. From December 2018 to August 2019, 85 patients (170 knees) who underwent bilateral total knee arthroplasty at our institution were randomly treated with MICP and FNB. Randomization was done via a computerized randomization list. The visual analogue scores for pain, bilateral knee range of motion (ROM), postoperative adverse events, and patients satisfaction were assessed preoperatively and two weeks postoperatively. This trial is registered at ClinicalTrials.gov, number ChiCTR1800020003. Results A total of 85 patients (170 knees) were enrolled for bilateral TKA. Finally, 80 (160 knees) patients were included for analysis and comparison. The operation time of the MCPI group was significantly lower than the FNB group (66.5±8.7 min compared with 72.8±9.5 min, P<0.05). postoperative 2nd，3rd and 5th days, the MCPI group in VAS for pain at rest and Straight elevated leg were significantly lower than FNB group (P<0.05). The knee flexion of MCPI group was statistically greater than FNB group on the postoperative 3rd, and 5th days (P<0.05). Conclusions MCPI analgesia is better than FNB after total knee arthroplasty, which can shorten the operation time, and evidently prolong the Postoperative effective analgesia duration. Higher patient satisfaction is beneficial to early postoperative recovery. Trial registration: Chinese Clinical Trials Registry, ChiCTR1800020003,11/12/2018
New design of miniature C-band substrate integrated waveguide bandpass filters using ceramic material

This article presents new structures and methods of design of miniature third-order substrate integrated waveguide (SIW) bandpass filters on a high-permittivity ceramic substrate for the C-band. The aim was to appraise the feasibility of such filters by using a 3D electromagnetic (EM) simulator. The substrate integrated waveguide (SIW) offers good quality factors and electrical performances compared with other planar techniques. Its integration capabilities and fabrication cost are other benefits that make it attractive. Ceramic material offer electrical properties suitable in designing of passive devices. High relative permittivity with low dielectric losses makes it possible to miniaturize passive components while exhibiting high temperature stability, which is an important selection criterion for a filter designed to equip the payload of a satellite. Three SIW filters were designed on a Trans-Tech ceramic substrate (thickness = 254 mm, er = 90, and tand = 0.0009) with drastic specifications for space application. The first filter is composed of three SIW resonators with direct coupling, the second is composed of three SIW resonators with a cross-coupling to create a transmission zero, and the third is composed of three SIW resonators with circular holes etched on the top of the metal layer to achieve a super-wide band. The obtained results for the proposed filters are presented, discussed, and compared with relevant published literature. The proposed filter can be used to enhance the performance of microwave devices used for C-band, especially Satellite communications.
ENHANCING NITROGEN FERTILIZER USE EFFICIENCY FOR MAIZE GROWN IN AN ALLUVIAL SOIL IN EGYPT USING NORMALIZED DIFFERENCE VEGETATION INDEX

A need-based nitrogen (N) management strategy using normalized difference vegetation index (NDVI) measured by an active optical sensor was evaluated for maize grown in an alluvial soil in Egypt. During 2019-2020, field experiments were performed to establish and validate an algorithm for refining the application of N fertilizer using NDVI. In the first season, an increasing rate of N fertilizer was applied to establish plots with different yield potentials and NDVI measurements were collected at V9 growth stage of maize. The second season aimed at validating the developed algorithm from the first season data by applying a corrective dose at V9 growth stage of maize.The results indicated that application of a prescriptive dose of 71 kg Nha-1 with sowing and 71 kg N ha-1 at 30 days after sowing, followed by a corrective dose guided by the sensor resulted in higher yield than the general recommendation with lower total fertilizer application. This treatment used 244 kg N ha-1 compared with 285 kg N ha-1 in the general recommendation. Recovery efficiency of N due to using the sensor was improved by 12.8 % (71.4 % in the sensor-guided application, whereas in the general recommendation was 5.8.6 %). This study revealed that using sensor-guided management, N fertilizer in maize could be managed more efficiently than the current general recommendation.
The Association Between COVID-19 and Hypertension: A Literature Review

Hypertension is a highly prevalent disorder and is estimated to affect at least one in every four individuals. Developing hypertension is mostly dependant on the patient’s lifestyle. It was reported among the comorbidities that were reported with the severity of COVID-19 infection. Reports showed that it is the commonest comorbidity that is associated with COVID-19 infection and severity. The prevalence of hypertension in COVID-19 patients is hugely variable and a rate of 15 35% has been reported by various investigations. Moreover, hypertensive patients are most prone to develop severe complications. The presence of hypertension and cardiovascular diseases were associated with increasing the risk of mortality by 2 3 times. Many reports estimated a significant association between hypertension and other comorbidities and mortality among COVID-19 patients. Additionally, the effect of hypertension is exaggerated when present with other co-morbidities as diabetes. Regarding the renin-angiotensin-aldosterone system (RAAS) inhibitors administration for controlling blood pressure in hypertensive COVID-19 patients, available data showed that no significant side effects were associated with these types of drugs. In fact, a previous report showed that RAAS inhibitors were significantly associated with reduced COVID-19 risks for developing severe disorders and death. Therefore, all theoretical approaches about the harmful effects of RAAS inhibitors when associated with COVID-19 infection should be ignored.
PREVALENCE OF PSYCHOLOGICAL TRAUMA IN HIV+ PATIENTS

4 Introduction . 5 Method . 11 Participants . 11 Procedure . 11 Evaluation and diagnostic Instruments . 11 Statistical analysis: . 14 Results . 15 Sample characteristics. 15 Clinical differences . 17 Relation between childhood trauma and clinical symptoms . 18 Discussion.20 Strengths and limitations . 23 Conclusions . 25 Bibliography . 26
Investigating the effectiveness of Physical Activity on Sleep Quality in consumers of tobacco

Tobacco smoking has been one of the most important causes of health problems and it is associated with an increased risk of many health (1, 2) and is linked to 6 million deaths annually(1). Poor sleep quality is a crucial public health issue in the 21st century (3). There is evidence that smoking can impair breathing and snoring during sleep (4). The results of the study showed that Cigarette smokers are at increased risk for poor sleep quality(5). Sleep disturbances were more prevalent among cigarette smokers than nonsmokers(6). A study reported the presence of symptoms of sleep apnea and sleep apnea syndrome in smokers. Also, sleep problems Article Type: Short Communication