Miracle-dz/UniFAR-FTUs huggingface dataset:
Power flow analysis in multi-terminal HVDC grid

Recent interests in developing a new type of grid have suggested the idea of the dc grid. However, the dc grid has less degrees of freedom than an ac grid which restricts its power flow control ability. To overcome this situation, an auxiliary dc voltage controller that would vary the voltage on a dc line can be inserted to provide additional degrees of control freedom. This paper investigates the benefits of adding such controller on a dc grid. The region of operation for a system with and without the auxiliary dc voltage controller is calculated. Two configurations are studied: a 3 terminals system with 3 lines and a 4 terminals system with 5 lines. The analysis confirms the enlargement of the region of operation for both systems and high sensitivity to voltage variations caused by the controller is explored.
Recommendation for Repeat Consumption from User Implicit Feedback

Most of the previous work on recommender systems focuses on discovering novel items that meet users' personalized interest. But there is barely any study about recommending repeat items that consumed by the target user before. In fact, people's consumption behaviors are a mixture of repeat and novelty-seeking behaviors [1]. Since people forget about things as time elapses, it is possible that users may prefer the previously consumed items but cannot remember them at certain times. Therefore, Recommendation for Repeat Consumption (RRC) has some real utility and should be studied in depth. Some efforts have been done in related work [1]. However, they only consider item popularity and recency effect, and fail to take full advantage of behavioral features. In this paper, we attempt to address the RRC problem (illustrated in Fig 1) by proposing a Time-Sensitive Personalized Pairwise Ranking (abbr. TS-PPR) model based on the behavioral features extracted from user implicit feedback in the consumption history. TS-PPR factorizes the temporal useritem interactions via learning the mappings from the behavioral features in observable space to the preference features in latent space, and combines users static and dynamic preferences together in recommendation. An empirical study on real-world data sets shows encouraging results.
Research of weight coefficient in efficiency evaluation of Tactical Data Link system based on AHP

It is an important problem needing to deal with for the evaluation of Tactical Data Link (TDL) system's efficiency.We establish the index system of efficiency evaluation according to the characteristics of TDL. Additionally, we analyze the TDL system from the four capabilities of signal processing, system safety, system usability and system cooperation. Finally, we ascertain the share of each index and calculate the influence caused by the stair and secondary index based on the sum-product method of AHP, realizing the sort routine of hiberarchy. It would be of a good value to the application and further research on TDL.
A multisite-directed mutagenesis using T 7 DNA polymerase : application for reconstructing

A method to introduce multiple mutations and to reconstruct genes, using a single oligodeoxyribonucleotide and DNA polymerase with high processivity, such as modified T7 DNA polymerase [Tabor and Richardson, Proc. Natl. Acad. Sci. USA 84 (1987a) 4767-47711, is described. A eukaryotic cDNA, coding for porcine growth hormone (pGH), was reconstructed in this study to delete 75 bp and to introduce a G + A transition. The deletion removes 75 bp and brings an ATG just upstream from the codon for the first amino acid in the mature protein. Moreover, the G 4 A substitution creates a new PvuII restriction site to facilitate further manipulation of the gene. Maximum mutation frequency with this multisite-directed mutagenesis is reached within 15 min with an efficiency approaching 50%, when using the modified T7 DNA polymerase. No multisite-directed mutants were obtained when T4 DNA polymerase or Klenow (large) fragment of DNA polymerase I were used. The described method is also applicable to simple single site-directed mutations as well as to more complex gene reconstruction strategies.
Stimulation of Type 1 and Type 8 Ca2+/Calmodulin-sensitive Adenylyl Cyclases by the Gs-coupled 5-Hydroxytryptamine Subtype 5-HT7AReceptor*

The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) plays an important regulatory role in developing and adult nervous systems. With the exception of the 5-HT3 receptor, all of the cloned serotonin receptors belong to the G protein-coupled receptor superfamily. Subtypes 5-HT6 and 5-HT7 couple to stimulation of adenylyl cyclases through Gs and display high affinities for antipsychotic and antidepressant drugs. In the brain, mRNA for 5-HT6 is found at high levels in the hippocampus, striatum, and nucleus accumbens. 5-HT7 mRNA is most abundant in the hippocampus, neocortex, and hypothalamus. To better understand how serotonin might control cAMP levels in the brain, we coexpressed 5-HT6 or 5-HT7A receptors with specific isoforms of adenylyl cyclase in HEK 293 cells. The 5-HT6receptor functioned as a typical Gs-coupled receptor in that it stimulated AC5, a Gs-sensitive adenylyl cyclase, but not AC1 or AC8, calmodulin (CaM)-stimulated adenylyl cyclases that are not activated by Gs-coupled receptors in vivo. Surprisingly, serotonin activation of 5-HT7Astimulated AC1 and AC8 by increasing intracellular Ca2+. 5-HT also increased intracellular Ca2+ in primary neuron cultures. These data define a novel mechanism for the regulation of intracellular cAMP by serotonin.
The elastic moduli of oriented tin oxide nanowires

Tin oxide nanowires (NWs) exhibit interesting electronic properties, which can be harnessed for applications in nanoelectronic devices and sensors. Oriented single crystalline tin oxide NWs were grown at 45° from a titanium dioxide substrate. Their elastic properties were investigated in a two-point geometry using an atomic force microscope (AFM) coupled with a scanning electron microscope under ultrahigh vacuum conditions. Young’s modulus was calculated by bending individual NWs and measuring the force exerted on the AFM tip during force–displacement measurements. For the NWs investigated, having radial dimensions below 45 nm and length up to 1.2 µm, we found an average value of 100 ± 20 GPa, which is below the theoretical predictions calculated for different SnO2 single crystal orientations, yet consistent with the indentation moduli of nanobelts. Finally, we discuss the effects of the nanowire–cantilever configuration on the measured Young’s modulus.
Multiple Attribute Decision Making Based on Generalized Aggregation Operators under Dual Hesitant Fuzzy Environment

We investigate the multiple attribute decision making (MADM) problems with dual hesitant fuzzy information. We first introduce some basic concepts and operations on dual hesitant fuzzy sets. Then, we develop some generalized dual hesitant fuzzy aggregation operators which encompass some existing operators as their particular cases and discuss their basic properties. Next, we apply the generalized dual hesitant fuzzy Choquet ordered aggregation (GDHFCOA) operator to deal with multiple attribute decision making problems under dual hesitant fuzzy environment. Finally, an illustrative example is given to show the developed method and demonstrate its practicality and effectiveness.
Crystal structure of Pseudomonas aeruginosa PAK pilin suggests a main-chain-dominated mode of receptor binding.

Fibers of pilin monomers (pili) form the dominant adhesin of Pseudomonas aeruginosa, and they play an important role in infections by this opportunistic bacterial pathogen. Blocking adhesion is therefore a target for vaccine development. The receptor-binding site is located in a C-terminal disulphide-bonded loop of each pilin monomer, but functional binding sites are displayed only at the tip of the pilus. A factor complicating vaccination is that different bacterial strains produce distinct, and sometimes highly divergent, pilin variants. It is surprising that all strains still appear to bind a common receptor, asialo-GM1. Here, we present the 1.63 A crystal structure of pilin from P. aeruginosa strain PAK. The structure shows that the proposed receptor-binding site is formed by two beta-turns that create a surface dominated by main-chain atoms. Receptor specificity could therefore be maintained, whilst allowing side-chain variation, if the main-chain conformation is conserved. The location of the binding site relative to the proposed packing of the pilus fiber raises new issues and suggests that the current fiber model may have to be reconsidered. Finally, the structure of the C-terminal disulphide-bonded loop will provide the template for the structure-based design of a consensus sequence vaccine.
Lymphocyte‐activation gene 3/major histocompatibility complex class II interaction modulates the antigenic response of CD4+ T lymphocytes

The activation requirements for antigen‐dependent proliferation of CD4+ T cells are well documented, while the events leading to the inactivation phase are poorly understood. Here, we tested the hypothesis that the lymphocyte‐activation gene 3 (LAG‐3), a second major histocompatibility complex (MHC) class II ligand, plays a regulatory role in CD4+ T lymphocyte activation. CD4+ class II‐restricted T cell clones were stimulated by their relevant antigen (hemagglutinin peptide or diphteria toxoid) and antigen‐presenting cells with or without anti‐LAG‐3 monoclonal antibody (mAb). Kinetic studies were performed to monitor different activation parameters, including the measurement of thymidine incorporation, expression of activation antigens and cytokine secretion. Results showed that the time course from the initial time points up to the peak time point was not modified in the presence of anti‐LAG‐3 mAb. However, addition of these antibodies, either as whole IgG or as Fab fragments, led to increased thymidine incorporation values for late time points and, hence, to a shift in the decreasing proliferation curve. We also showed that expression of activation antigens, such as CD25, was higher in the presence of anti‐LAG‐3 mAb, and that cytokine concentrations, i.e. of interferon‐γ or interleukin‐4, were higher in the corresponding culture supernatants. In addition, we tested whether the effects of anti‐LAG‐3 mAb were limited to antigen‐dependent. MHC class II‐restricted responses. The proliferative responses of CD4+ T cell clones following stimulation with either interleukin‐2, mitogens, a combination of anti‐CD2 mAb, immobilized anti‐CD3 or anti‐T cell receptor mAb were not altered by anti‐LAG‐3 mAb. The allogeneic proliferative response of a CD8+ T cell clone was also not affected. Overall, the present analysis reveals a modulating effect of anti‐LAG‐3 mAb, mediated specifically on antigen‐dependent, MHC class II‐restricted responses of CD4+ T cell lines. These results support the view that LAG‐3/MHC class II interaction down‐regulates antigen‐dependent stimulation of CD4+ T lymphocytes.
A stable homotopy approach to horizontal linear complementarity problems

We are interested in the solution of Horizontal Linear Complementarity Problems, HLCPs, that is complementarity prob- lems with more variables than equations. Globally metrically regular HLCPs have nonempty solution sets that are stable with respect to "right-hand-side perturbations" of the data, hence are numerically at- tractive. The main purpose of the paper is to show how the stability or conditioning properties of globally metrically regular HLCPs are pre- served by a homotopy framework for solving the HLCP that finds a "stable" direction at each iteration as a local minimizer of a strongly convex quadratic program with linear complementarity constraints, QPCC. Apart from intrinsic interest in numerical solution of HLCPs, this investigation has application in solving horizontal nonlinear com- plementarity problems and more broadly in the area of mathematical programs with complementarity constraints, MPCCs.
Research of main memory database data organization

Main Memory Database(MMDB) for its fast data access capability, it is more suitable for fast response and high transaction throughput applications than Disk-Resident Database(DRDB). Especially, as the price of random access memory dropping and a large number of real-time applications disappeared, MMDB becomes hot research topic in the database. It analyzed the difference between MMDB and DRDB in terms of system characteristics, the algorithm targets and index structure, etc; Then it introduces some of the data organization which used in MMDB, highlight several typical types of index structures; At last, it analyzed the algorithm's time efficiency and space efficiency and given the prospects of future research directions.
Color recovery from gray image based on analysis of wavelet packet sub-bands

This paper proposes a colorization method that uses wavelet packet sub-bands to embed color components. The proposed method, firstly, involves a color-to-gray process, in which an input RGB image is converted into Y, Cb, and Cr images, and a wavelet packet transform applied to Y image to divide it into 16 sub-bands. The Cb and Cr images are then embedded into two sub-bands that include minimum information on the Y image. Once the inverse wavelet packet transform is carried out, a new gray image with texture is obtained, where the color information appears as texture patterns that are changed according to the Cb and Cr components. Secondly, a gray-to-color process is performed. The printed textured-gray image is scanned and divided into 16 sub-bands using a wavelet packet transform to extract the Cb and Cr components, and an inverse wavelet packet transform is used to reconstruct the Y image. At this time, the original information is lost in the color-to-gray process. Nonetheless, the details of the reconstructed Y image are almost the same as those in the original Y image because it uses sub-bands with minimum information to embed the Cb and Cr components. The RGB image is then reconstructed by combining the Y image with the Cb and Cr images. In addition, to recover color saturations more accurately, gray patches for compensating the characteristics of printers and scanners are used. As a result, the proposed method can improve both the boundary details and the color saturations in recovered color images.
High throughput long integer multiplication using Fast Fourier Transform on parallel workstation

In this paper, we have proposed high throughput parallel long integer multiplication algorithm on parallel workstation. In integer arithmetic operations, long integer multiplication is the most time consuming and key operation. In public-key cryptography such as RSA, Diffie-Hellman and so on long integer multiplication is required. Long integer multiplication operation is performed heavily for the computation of exponentiation. This computation affects and bottlenecks the overall performance of cryptography process. We used floating point Fast Fourier Transform (FFT) for parallel implementation of long integer multiplication to accelerate these cryptography processes. This paper aims on high throughput and practical parallel implementation of long integer multiplication on newly available parallel processors such as multiple cores CPUs and many cores Graphics Processing Units (GPUs). We analyze and present the results on FFT benchmarks fast libraries for long integer multiplication on parallel workstation.
Incidence and implications of chemotherapy related hand-foot syndrome

ABSTRACT Introduction: Hand-foot syndrome (HFS) is a well-established cutaneous adverse event of certain chemotherapeutic agents, mainly capecitabine, continuously infused 5-fluorouracil, docetaxel and pegylated liposomal doxorubicin. Erythema, dysesthesia, pain, cracking and desquamation located on palms and soles are the most characteristic manifestations. Although HFS is a reversible and non-life-threatening clinical condition, it can often affect patient’s quality of life significantly, hence necessitating therapeutic modifications or even treatment discontinuation. Areas covered: This is review article on current data regarding the clinical characteristics, grading and management of HFS. Special focus has been given to recent literature studying novel therapeutic strategies. Expert opinion: Early recognition, patient education and supportive measures are considered as the key elements in the management of HFS. Up to date, treatment interruption and dose intensity reduction are the mainstay of HFS management. Many topical formulations and systemic treatment regimens have been proposed, with COX-2 inhibitors being the most promising agents. Nevertheless, large prospective randomized controlled trials are needed in order to agree on solid, evidence-based treatment algorithms.
Deficiency of Sbds in the mouse pancreas leads to features of Shwachman-Diamond syndrome, with loss of zymogen granules.

BACKGROUND & AIMS Shwachman-Diamond syndrome (SDS) is the second leading cause of hereditary exocrine pancreatic dysfunction. More than 90% of patients with SDS have biallelic loss-of-function mutations in the Shwachman-Bodian Diamond syndrome (SBDS) gene, which encodes a factor involved in ribosome function. We investigated whether mutations in Sbds lead to similar pancreatic defects in mice. METHODS Pancreas-specific knock-out mice were generated using a floxed Sbds allele and bred with mice carrying a null or disease-associated missense Sbds allele. Cre recombinase, regulated by the pancreatic transcription factor 1a promoter, was used to disrupt Sbds specifically in the pancreas. Models were assessed for pancreatic dysfunction and growth impairment. RESULTS Disruption of Sbds in the mouse pancreas was sufficient to recapitulate SDS phenotypes. Pancreata of mice with Sbds mutations had decreased mass, fat infiltration, but general preservation of ductal and endocrine compartments. Pancreatic extracts from mutant mice had defects in formation of the 80S ribosomal complex. The exocrine compartment of mutant mice was hypoplastic and individual acini produced few zymogen granules. The null Sbds allele resulted in an earlier onset of phenotypes as well as endocrine impairment. Mutant mice had reduced serum levels of digestive enzymes and overall growth impairment. CONCLUSIONS We developed a mouse model of SDS with pancreatic phenotypes similar to those of the human disease. This model could be used to investigate organ-specific consequences of Sbds-associated ribosomopathy. Sbds genotypes correlated with phenotypes. Defects developed specifically in the pancreata of mice, reducing growth of mice and production of digestive enzymes. SBDS therefore appears to be required for normal pancreatic development and function.
Epigenetics and Tumor Suppressor Genes

Genes which protect cells from malignant transformation were referred to as tumor suppressor genes (TSGs). Since the first description of TSG, Rb (retinoblastoma susceptibility gene), a myriad of genes have been identified as TSGs. These TSGs play critical roles in cell cycle control, apoptosis, DNA damage detection and repair, adhesion, metastasis, senescence, and carcinogen detoxification. Loss function of TSGs may cause uncontrolled cell growth and cancer. TSGs may be inactivated by different mechanisms during carcinogenesis. In addition to genetic changes, epigenetic aberration plays an important role in inactivation of TSGs. Epigenetics is described as heritable changes in gene expression that do not involve a change in the DNA sequence (Berger et al., 2009). DNA methylation and histone modification are two predominant epigenetic changes. More recently, non-coding RNAs were regarded as new epigenetic regulation tools. The purpose of this chapter is to describe the effects of epigenetic modification on TSGs.
Association of Angiotensinogen Gene Polymorphisms with Essential Hypertension in African-Americans and Caucasians

Obective: Molecular variants of angiotensinogen (AGT) have been linked to essential hypertension, and promoter variants have been shown to alter the transcription rate of AGT in vitro. We employed a case-control study to determine whether single nucleotide polymorphisms (SNPs) in the promoter region of AGT were associated with hypertension in African-Americans and Caucasians. Methods: The frequencies of the variants at base positions –6, –20, –217, –793, and –776, both alone and in combination (haplotypes), were compared between cases and controls in samples stratified based on race and sex. A logistic regression model was applied to test whether AGT genotypes were significant predictors of the disease while adjusting for race, sex, and age. Results: Subjects with the AA or AG genotype at locus –793 were significantly more likely to have the disease (OR = 1.88, 95% CI = 1.12–3.15). Additionally, the differences in haplotype frequency distributions between cases and controls were significant at the 7% level for all four subgroups (stratified by race and sex) after adjusting for multiple testing. Based on the odds ratios for each individual haplotype, the haplotype AAAAT (nucleotide sequences at base positions –6, –20, –217, –793, –776) in African-American males, African-American females, and Caucasian females may confer susceptibility to the disease in these population subsets. Conclusion: Overall, the present report provides statistical evidence for the association of AGT with essential hypertension.
Cryotolerance of stallion spermatozoa is related to ROS production and mitochondrial membrane potential rather than to the integrity of sperm nucleus

Although cryopreservation of stallion spermatozoa allows long‐term preservation of spermatozoa from particular stallions and facilitates international trade, it is understood to inflict damages on sperm cells that may finally reduce their fertilizing ability. In addition, individual differences are known to exist in the sperm ability to withstand freeze‐thawing protocols. To date, these differences have mainly been reported on the basis of sperm motility and membrane integrity. For this reason, the present work sought to determine differences between good (good freezability ejaculates: GFE) and poor (poor freezability ejaculates: PFE) freezability stallion ejaculates in other sperm parameters, including peroxide and superoxide levels, potential of mitochondrial membrane and nuclear integrity. With this purpose, a total of 24 stallion ejaculates were cryopreserved and classified into two groups (GFE vs. PFE), depending on their sperm membrane integrity and motility after freeze‐thawing. From the total of 24 ejaculates, 13 were classified as GFE and the other 11 were classified as PFE. Apart from differences in sperm membrane permeability and lipid disorder after freeze‐thawing, GFE presented significantly (p < 0.05) higher percentages of viable spermatozoa with high content of peroxides and of superoxides than PFE. In contrast, and despite cryopreservation of stallion spermatozoa increasing DNA fragmentation and disrupting disulphide bonds in sperm head proteins, no significant differences between GFE and PFE were seen. We can thus conclude that good and poor freezability stallion ejaculates differ in their reactive oxygen species levels after cryopreservation, but not in the damage extent on sperm nucleus.