Miracle-dz/UniFAR-FTUs huggingface dataset:
Association between serum Krebs von den Lungen-6 ( KL-6 ) , Carcinoma antigen 15-3 ( CA 15-3 ) , and connective tissue disease-related interstitial pneumonia ( CTD-ILD )

We investigated the association between Krebs von den Lungen-6 (KL-6), Carcinoma antigen 15-3 (CA153), and the severity of connective tissue disease-related interstitial pneumonia (CTD-ILD) to explore their significance in CTD-ILD diagnosis and disease management. 199 patients were divided into CTD group (43 cases) and CTD-ILD group (156 cases). Serum KL-6 and CA15-3 levels and clinical manifestations were used to conduct a cross-sectional analysis. Data was obtained from 57 CTD-ILD patients before and after treatment, after which they were divided into the progression group, remission group, and stabilization group, A longitudinal analysis was then conducted. The levels of serum KL-6 and CA15-3 in the CTD-ILD group were significantly higher than those in the CTD group (P < 0.01). If joint criteria of KL-6 ≥ 397.50 U/ml or CA15-3 ≥ 19.73 ng/mL were used in the diagnosis of CTD-ILD, the positive predictive value reached 95.61%, in which case the sensitivity and specificity were 82.57% and 82.75%. The horizontal analysis showed that the levels of KL-6 and CA15-3 in CTD-ILD patients were negatively correlated with lung function (percentage of predicted forced vita capacity (FVC% pred), percentage of predicted forced expiratory volume in 1 s (FEV1% pred), percentage of predicted total lung capacity (TLC% pred), percentage of predicted diffusion lung capacity for carbon monoxide (DLCO% pred)) (P < 0.05). Longitudinal analysis showed that the changes in KL-6 (ΔKL-6) and CA15-3 (ΔCA15-3) were negatively correlated with the changes in FVC% pred (ΔFVC% pred) and FEV1% pred (ΔFVC% pred) before and after treatment in 57 CTD-ILD patients. In addition, the levels of KL-6 and CA15-3 in the progression group increased along with the deterioration of the disease.Serum KL-6 and CA15-3 was positivly correlated with the severity of CTD-ILD The combined detection of serum KL-6 and CA15-3 can improve the diagnosis of CTD-ILD. Dynamic monitoring of changes in KL-6 and CA15-3 levels were conducive for effective management and monitoring of this disease.
Research Hypothesis Generation Using Link Prediction in a Bipartite Graph

The large volume of scientific publications is likely to have hidden knowledge that can be used for suggesting new research topics. We propose an automatic method that is helpful for generating research hypotheses in the field of physics using the massive number of physics journal publications. We convert the text data of titles and abstract sections in publications to a bipartite graph, extracting words of physical matter composed of chemical elements and extracting related keywords in the articles. The proposed method predicts the formation of new links between matter and keyword nodes based on collaborative filtering and matter popularity. The formation of links represents research hypotheses, as it suggests the new possible relationships between physical matter and keywords for physical properties or phenomena. The suggested method has better performance than existing methods for link prediction in the entire bipartite graph and the subgraph that contains only a specific keyword, such as ‘antiferromagnetism’ or ‘superconductivity. ’ Our suggested concept for generating research hypotheses can be easily extended to various other research topics or industrial topics using patent literature.
In Silico Homology Modeling and Epitope Prediction of Outer Membrane Protein OMP W, A Potential Vaccine Candidate against Edwardsiella tarda

Edwardsiella tarda (E. tarda) is a Gram negative, motile, short, rod-shaped bacterium (1 μm in diameter and 2–3 μm long) belonging to the family Enterobacteriaceae. The host range of the pathogen includes human beings, fresh water and salt water fishes, snakes (Czirják et al., 2008), tortoises (Sechter et al., 1983), crocodiles (Revol, 1995), seals (Thornton et al., 1998) and frogs (Sharma et al., 1974). Edwardsiella has been implicated in gastroenteritis in humans (Spencer et al., 2008) and in bacteremic infections that include liver abscesses (Manchanda et al., 2006) and peritonitis with sepsis (Clarridge et al., 1980). The bacterium causes edwardsiellosis / emphysematous putrefactive disease leading to mass mortality in various populations and age groups of fish. It has become one of the most serious threats to flounder farming (Kusuda and Kawai, 1998) and cat fish farming (Ye et al., 2009). Studies have shown that E. tarda is resistant to colicins (Stock and Wiedemann, 2001) and possess beta lactamase (Welch et al., 2009) International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 7 Number 03 (2018) Journal homepage: http://www.ijcmas. com
Development of a DMD-based fluorescence microscope

We present a versatile fluorescence microscope, built by complementing a conventional fluorescence microscope with a digital micro-mirror device (DMD) in the illumination path. Arbitrary patterns can be created on the DMD and projected onto the sample. This patterned illumination can be used to improve lateral and axial resolution over the resolution of a wide-field microscope, as well as to reduce the illumination dose. Different illumination patterns require different reconstruction strategies and result in an image quality similar to confocal or structured illumination microscopy. We focus on the optical design and characterization of a DMD-based microscope. Estimation of the optical quality of the microscope has been carried out by measuring the modulation transfer function from edge profiles. We have obtained optically sectioned images by applying multi-spot illumination patterns followed by digital pinholing. The sectioning capabilities of our DMD-based microscope were estimated from the dependence of the signal-to-background and signalto-noise ratios on the pitch of the projected multi-spot patterns and the size of the digital pinhole. In addition, we provide an outlook on the use of pseudo-random illumination patterns for achieving both sectioning and resolution enhancement.
A Comparison of Cellulose Extraction and ABA Pretreatment Methods for AMS 14C Dating of Ancient Wood

We have compared accelerator mass spectrometry (AMS) radiocarbon results on wood samples at or near the limit of 14C dating, pretreated with a standard acid-base-acid (ABA) protocol, with those obtained from cellulose prepared from the same samples by several modifications of the Jayme-Wise cellulose extraction method (Green 1963). These tests were carried out to determine the most efficient way to ensure low backgrounds in 14C measurements of well-preserved ancient wood samples.
Resilient Identity for Blind Users

-- Automated Teller Machine (ATM), which provides the audible interactions to the blind users, can access their transactions using audio jack and Biometric scanner. The audio jack is the right way to convey the instruction through speaker system to the blind users with a high confidential security. The Biometric is the fundamental mechanism to scan proper person. In this paper, that we are mainly focusing on the audio jack with Biometric scanner ATM for blind users. That will overcome the problem of fraud in hacking. In the future, the blind people can make the transaction of ATM in a secure manner.
Influence of the North Atlantic Oscillation on air pollution transport

Abstract. We examined the influence of the North Atlantic Oscillation (NAO) on the atmospheric dispersion of pollution by computing the emission, transport and removal of idealized insoluble gaseous and water-soluble aerosol tracers, tagged by the continent of origin. We simulated a period of 50 yr (1960–2010), using the ECHAM5/MESSy1 atmospheric chemistry (EMAC) general circulation model. The model accounts for anthropogenic, biogenic and biomass burning sources, removal of trace gases through OH oxidation, and precipitation, sedimentation and deposition of aerosols. The model is shown to reproduce the observed spatial features of the NAO, moisture transports and precipitation. During high NAO phase seasons the axis of maximum westerly North American trace gas transports extends relatively far to the north and east over Europe. The NAO phase is significantly correlated with North American insoluble gas and soluble aerosol tracer concentrations over the northwestern Atlantic Ocean and across northern Europe, and with European trace gases and aerosols over Africa and north of the Arctic circle. We find a strong anti-correlation between the phase of the NAO and European pollutant gas concentration over western and central Europe.
Piezoelectricity in collagen type II fibrils measured by scanning probe microscopy

The converse piezoelectric effect in collagen type II fibrils, the main collagen constituent in cartilage, was investigated using piezoresponse force microscopy. The fibrils exhibited shear piezoelectric behavior similar to that previously reported in collagen type I fibrils and followed the same cantilever-fibril angle dependence present for type I. A uniform polarization directed from the amine to carboxyl termini, as seen for collagen type I, was observed in all type II fibrils studied. The shear piezoelectric coefficient, d15, however, for type II was roughly 28–32% of the value measured for type I fibrils. Possible explanations for the reduced piezoelectric coefficient of type II collagen are provided.
Multilayer structure formation via homophily and homeostasis

The competition of homophily and homeostasis mechanisms taking place in the multilayer network where several layers of connection topologies are simultaneously present as well as the interaction between layers is considered. We have shown that the competition of homophily and homeostasis leads in such networks to the formation of synchronous patterns within the different layers of the network, which may be both the distinct and identical.
Satellite Chartography of Atmospheric Methane and carbon monoxide from SCIAMACHY onboard ENVISAT

The UV/Vis/near infrared spectrometer SCIAMACHY on board the European ENVISAT satellite enables total column retrieval of atmospheric methane with high sensitivity to the lower troposphere. The vertical column density of methane is converted to column averaged mixing ratio by using carbon dioxide retrievals as proxy for the probed atmospheric column. For this purpose, we apply concurrent total column measurements of CO_2 in combination with modeled column-averaged CO_2 mixing ratios. Possible systematic errors are discussed in detail while the precision error is 1.8% on average. This paper focuses on methane retrievals from January 2003 through December 2004. The measurements with global coverage over continents are compared with model results from the chemistry–transport model TM4. In the retrievals, the north-south gradient as well as regions with enhanced methane levels can be clearly identified. The highest abundances are found in the Red Basin of China, followed by northern South America, the Gangetic plains of India and central parts of Africa. Especially the abundances in northern South America and the Red Basin are generally higher than modeled. Further, we present the seasonal variations within the investigated time period. Peak values in Asia due to rice emissions are observed from August through October. We expand earlier investigations that suggest underestimated emissions in the tropics. It is shown that these underestimations show a seasonal behavior that peaks from August through December. The global measurements may be used for inverse modeling and are thus an important step towards better quantification of the methane budget.
Phytoremediation of Cadmium by Ricinus communis L . in Hydrophonic Condition

The potential of Ricinus communis L was investigated for the phytoextraction of cadmium (Cd) in hydrophonic condition. The studied plants were grown under greenhouse condition in 250 ml flasks containing a nutrient solution with increasing doses of Cd (0, 5, 10, 15, 20 and 25 mg/L) for 28 days. The growth and physiological parameters of plants were determined at the end of the experiment. Cd contents in plant tissues were found increasing with increasing dose of Cd. The maximum Cd uptake was found at T5 (25 mg/L of Cd). The pattern of Cd accumulation in different part of plant was found as: root > leaf > stem. The maximum BAF was found in T2 (10 mg/L of Cd) and for whole plant BAF value was ranged from 0.286-0.455. Translocation factor (TF) value was ranged from 0.645-0.857 and 0.626-0.837 for root-shoot and shoot-leaves respectively. All BAF and TF values were found less than 1. The plant height, root length and total plant dry-biomass was significantly reduced by Cd treatment as compared with control. Cd stress also increased proline concentration in root and leaves and maximum proline content (81.3 μg/g) was found in T3 (15 mg/L of Cd). Total phenolic content (TPC) was also increased under Cd-stress and maximum (55 and 59 mgGAE/g DW) TPC was found in T4 (20 mg/L of Cd) for root and leaves respectively. The TPC in leaves was found higher than root, while root proline was found higher than leaves.
A Combined Expectation Maximization and Marker Controlled Watershed Driven Distance Regularized Level Sets for Nuclear Segmentation in Histopathological Images

Detection of significant biomarker has been a major issue in the pathological study of cancerous tissue. The microscopic observation of H&E stained histopathological slides involves the study of various tissue objects and their significant traits influencing the cancer grading. The change in shape and size of the nuclei objects (nuclear pleomorphism) contributes much significantly in grading the cancer. With the advent of various imaging studies over a digitized Histopathological image, Active contour based segmentation approaches are considered to be much potential scheme in detecting the nuclei within occlusions and extracting their irregular boundaries. In this research, a novel approach of driving the contours of distance regularized level sets using an improved watershed transformation, has been presented. An Expectation Maximization based morphologically precomputed shape prior is used to extract the foreground markers, which controls the watershed transformation. The result of watershed transformation is used compute the centroid of nuclei to serve the initialization of the contour and the proposed gradient to drive the same efficiently. The study performed over the Benign and Malignant tissue images from BreakHis dataset has shown the efficacy of the methodology in terms of
The effect of 900 MHz microwave GSM signal on the proliferation of endothelial cells in vitro

Angiogenesis, the growth of new vessels from existing microvasculature, has an obvious and essential role in wound healing [1]. Wound healing is a complex biological process, comprised of a series of sequential events aiming to repair injured tissue. Immune system participates in this process not only through elimination of infective agents at the site of injury, but also by contribution to the process of healing [2]. A lot of molecules and cells of the immune system participate in wound healing process. Growth factors secreted by different cells (macrophages, neutrophils, lymphocytes, fibroblasts, platelets) induce cells to migrate, divide or produce other factors influenced on wound healing. These factors bind to target cells via specific cell surface receptors and exert inhibitory or stimulatory response. The first phase of the wound healing process (cellular migration and inflammation) lasts several days and is initiated by the process of blood clotting and platelet degranulation. Granules of platelets release various growth factors (PDGF, IGF1, EGF, TGF-β, TSP1) which initiate sequences of events leading to healing. A pleiotropic cytokine macrophage migration inhibitory factor (MIF) appears early in wound and exerts both positive and negative effects on the healing process. Macrophages have many functions in wounds, including host defense, the promotion of inflammation, the removal of apoptotic cells, and the influence on cell proliferation and tissue repair. Neutrophils and macrophages enter the wound and begin to synthetise and secrete other important growth factors, among them interleukin 1 (IL-1) and proangiogenic cytokines vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF, or FGF-2). These factors stimulate migration of fibroblasts, epithelial cells and vascular endothelial cells into wound [3-10]. Abstract Pulsed electromagnetic fields (PEMF) have been shown to be clinically beneficial, effective for bone and wound repair, but their mechanism of action is not fully elucidated. Angiogenesis plays an important role in injured tissue healing and during the wound repair many potential angiogenic factors are released. It was reported that PEMF may increase angiogenesis through endothelial release of basic fibroblast growth factor (bFGF). Moreover, an increase of protein synthesis by cells exposed to a 1,800-MHz radiofrequency mobile phone PEMF was detected by proteome profiling. We previously reported that immune activity of lymphocytes and monocytes in culture can be intensified by 900 MHz microwaves. In the present study, we performed experiments with murine endothelial cell line HECa10, exposed to the influence of pulse modulated 900 MHz microwave electromagnetic field. Fifteen minutes exposure resulted in significant stimulation of endothelial cells proliferation rate, what we evaluated by two independent methods (Alamar Blue reduction and 3H thymidine incorporation).
An Intensity Method for Measuring Absorption Properties in situ

The well-known Kundt’s tube and reverberant room method are often used for measurement of acoustic absorption properties of samples under laboratory conditions. Several in situ measurement methods exist, but most of them are limited in frequency range, require large samples and/or are vulnerable to background noise or reflections. The PU in situ impedance method [1, 2] has been used successfully on relatively small samples (> 0.1m2) in a broad frequency range (300 Hz− 10 kHz) under reverberant conditions (e.g. a car interior or a concert hall), see e.g. [3, 4, 5, 6, 7]. The small source-sample and probe-sample distance are the main reasons for the relative small sample size requirement and the low influence to background noise and reflections. However, in some cases the procedure shows artefacts because all the reflection at the top of the sample is considered, not taking into account wave propag tion in the material. In this research the principle of measuring intensity instead of impedance is investigated. To eliminate near field effects an extrapolation technique is introduced that combines several measurements. The result is a technique to measure the absorption coefficient without knowledge of the material. The methods are examined theoretically and verified with experiments.
Introduction: A Contextual and Resource-Integrative View of Value Creation

Review of Marketing Research, now in its ninth volume, is a well-established publication covering the important areas of marketing research with a more comprehensive state-of-the-art orientation. The chapters in this publication review the literature in a particular area, offer a critical commentary, develop an innovative framework, and discuss future developments, as well as present specific empirical studies. The first eight volumes have featured some of the top researchers and scholars in our discipline who have reviewed an array of important topics. The response to the first eight volumes has been truly gratifying and we look forward to the impact of the ninth volume with great anticipation.
Multi-model Markov decision processes

Abstract Markov decision processes (MDPs) have found success in many application areas that involve sequential decision making under uncertainty, including the evaluation and design of treatment and screening protocols for medical decision making. However, the data used to parameterize the model can influence what policies are recommended, and multiple competing data sources are common in many application areas, including medicine. In this article, we introduce the Multi-model Markov decision process (MMDP) which generalizes a standard MDP by allowing for multiple models of the rewards and transition probabilities. Solution of the MMDP generates a single policy that maximizes the weighted performance over all models. This approach allows the decision maker to explicitly trade-off conflicting sources of data while generating a policy of the same level of complexity for models that only consider a single source of data. We study the structural properties of this problem and show that it is at least NP-hard. We develop exact methods and fast approximation methods supported by error bounds. Finally, we illustrate the effectiveness and the scalability of our approach using a case study in preventative blood pressure and cholesterol management that accounts for conflicting published cardiovascular risk models.
SnailTrail : Online Bottleneck Detection for your Dataflow †

Motivation Understanding the performance of large-scale data processing applications is hard. In distributed dataflow systems, the computation of several parallel processes is interleaved with data and control communication and execution dependencies typically span multiple system components. In such an environment, bottleneck detection is cumbersome and currently relies heavily on humans. After decades of systems research, the state-of-the-art in performance analysis still relies on offline trace processing, thus it is only suitable for batch computations and post-mortem reports. This work presents SnailTrail, a novel framework for online performance analysis in modern dataflow engines that can identify bottlenecks in real-time and make automated optimization possible at runtime.
COST Action CA 15104 Deliverable 4 Whitepaper on New Localization Methods for 5 G Wireless Systems and the Internet-of-Things

Disruptive technologies proposed for 5G wireless systems and the IoT hold promise of providing unprecedented localization capabilities for a wide range of application scenarios and target environments. This whitepaper summarizes the expected features and resulting properties of upcoming localization systems exploiting 5G and IoT technologies. It also identifies the important theoretical limitations and practical implementation challenges at hand and recommends potential paths forward towards more accurate, robust, and secure location-based services.
On the sensitivity of root and leaf phenology to warming in the Arctic

ABSTRACT Temperature is commonly assumed to act as the primary constraint on the timing of plant growth, and strong advances in plant phenology have been seen with recent atmospheric warming. The influence of temperature on the timing of root growth, however, is less clear, and controls on root phenology are not well understood. The influence of temperature on above- and belowground phenology is particularly important in the Arctic, where most plant biomass is belowground and warming is occurring at a higher rate than in other ecosystems. We examined the influence of experimental warming on graminoid and shrub communities in the Arctic in southern west Greenland. We found that warming since 2012 did not advance the timing of aboveground seasonal dynamics during two years or belowground seasonal dynamics during three years. We suggest that growing-season temperature may no longer be the primary constraint on plant phenology at this site, and plant phenological responses to future warming at the site may consequently be weaker.