Miracle-dz/UniFAR-FTUs huggingface dataset:
Entropy, Free Energy, and Symbolization: Free Association at the Intersection of Psychoanalysis and Neuroscience

Both a method of therapy and an exploration of psychic reality, free association is a fundamental element of psychoanalytical practices that refers to the way a patient is asked to describe what comes spontaneously to mind in the therapeutic setting. This paper examines the role of free association from the point of view of psychoanalysis and neuroscience in order to improve our understanding of therapeutic effects induced by psychoanalytic therapies and psychoanalysis. In this regard, we first propose a global overview of the historical origins of the concept of free association in psychoanalysis and examine how Freud established its principles. Then, from Freud’s distinction between primary and secondary processes, we proceed to compare the psychoanalytic model with research originating from cognitive psychology and neuroscience. The notions of entropy and free energy appear particularly relevant at the intersection of these different domains. Finally, we propose the notion of symbolizing transmodality to describe certain specificities of symbolization processes within free association and we summarize the main functions of free association in psychoanalytic practices.
Beta HPV Type 15 Can Interfere With NF-κB Activity and Apoptosis in Human Keratinocytes

E7 protein from cutaneous as well as mucosal HPV types can alter NF-κB activity. Conflicting literature data show a HPV-induced up- or down-regulation of the NF-κB pathway in different cell lines. In a previous study we detected the expression of E7 gene of HPV15 in a subungual tumor of a patient affected by incontinentia pigmenti (IP). IP is a rare X-linked genodermatosis in which the IKKγ gene is altered. From observations in transgenic IKKγ defective mice, it was suggested that IKK-deficient cells may undergo rapid hyper-proliferation and apoptosis/necrosis, leading to increased pro-inflammatory cytokine production in the neighboring IKK-positive cells. The objective of this study was to ascertain if beta HPV 15 can alter apoptosis and NF-κB pathway in normal and IKKγ-deficient keratinocytes. The human immortalized keratinocyte cell line (HaCaT), and human primary keratinocyte (HPK) cells were transduced with a retrovirus expressing E6–E7 proteins of HPV 15 and IKKγ was successful silenced mimicking the HPV15 infection and IP. HPV15 E6–E7 gene expression improved NF-κB activity in human keratinocytes even when IKKγ was silenced by siRNA. In IKKγ silenced keratinocyte cells, TNF-α-induced apoptosis was strongly reduced by the expression of HPV15 E6–E7 genes. Beta HPV15 exerted this anti-apoptotic activity by decreasing pro-apoptotic BAK and cleaved Caspase 3 proteins. In conclusion, we can speculate that presence of persistent infection by beta papillomavirus might influence the biological fate of IP by altering NF-κB activation and apoptosis in IKKγ mutated cells, favoring their survival and possibly the development of tumors in the late stage of disease. Taken together, our data reinforce the importance of host genetic background in the pathogenesis of HPV-associated skin lesions.
Na+/Ca2 + Exchange and Pacemaker Activity of Interstitial Cells of Cajal

Interstitial cells of Cajal (ICC) are pacemaker cells that generate electrical slow waves in gastrointestinal (GI) smooth muscles. Slow waves organize basic motor patterns, such as peristalsis and segmentation in the GI tract. Slow waves depend upon activation of Ca2+-activated Cl– channels (CaCC) encoded by Ano1. Slow waves consist of an upstroke depolarization and a sustained plateau potential that is the main factor leading to excitation-contraction coupling. The plateau phase can last for seconds in some regions of the GI tract. How elevated Ca2+ is maintained throughout the duration of slow waves, which is necessary for sustained activation of CaCC, is unknown. Modeling has suggested a role for Na+/Ca2+ exchanger (NCX) in regulating CaCC currents in ICC, so we tested this idea on murine intestinal ICC. ICC of small and large intestine express NCX isoforms. NCX3 is closely associated with ANO1 in ICC, as shown by immunoprecipitation and proximity ligation assays (PLA). KB-R7943, an inhibitor of NCX, increased CaCC current in ICC, suggesting that NCX, acting in Ca2+ exit mode, helps to regulate basal [Ca2+]i in these cells. Shifting NCX into Ca2+ entry mode by replacing extracellular Na+ with Li+ increased spontaneous transient inward currents (STICs), due to activation of CaCC. Stepping ICC from −80 to −40 mV activated slow wave currents that were reduced in amplitude and duration by NCX inhibitors, KB-R7943 and SN-6, and enhanced by increasing the NCX driving force. SN-6 reduced the duration of clustered Ca2+ transients that underlie the activation of CaCC and the plateau phase of slow waves. Our results suggest that NCX participates in slow waves as modeling has predicted. Dynamic changes in membrane potential and ionic gradients during slow waves appear to flip the directionality of NCX, facilitating removal of Ca2+ during the inter-slow wave interval and providing Ca2+ for sustained activation of ANO1 during the slow wave plateau phase.
Process for Growth of Group-IV Alloys Containing Tin by Remote Plasma Enhanced Chemical Vapor Deposition

A remote plasma enhanced chemical vapor deposition (CVD) process using GeH4, SiH4, and SnCl4 precursors has been developed for epitaxial growth of group-IV alloys directly on Si (100) substrates, without the need for buffer layers. X-ray diffraction measurements of a representative Ge1–xSnx sample which is 233 nm thick, with x = 9.6% show it to be highly oriented along the [001] direction and nearly relaxed, with 0.37% compressive strain. Ellipsometry measurements provide a pseudo-dielectric function which is well fitted by a 3-layer (substrate/alloy/surface oxide) model. Cross-sectional transmission-electron-microscope images show a highly defective interface layer, ∼ 60 nm thick, containing edge dislocations and stacking faults; above this layer, the lattice is well-ordered, with a much lower density of defects. Atomic force microscopy measurements show an RMS roughness of 1.2 nm for this film.
A SLM-based overlay architecture for fine-grained virtual FPGA

FPGA overlay technologies have been introduced to provide inter-FPGA bitstream compatibility by implementing virtual FPGA (vFPGA) layers on physical devices. Conventional LUT-based fine-grained vFPGAs have very large resource overheads. In this paper, we propose a fine-grained vFPGA overlay architecture that employs our previously proposed scalable logic module (SLM) as a logic cell. SLMs can cover most frequently used logics with far fewer hardware resources than LUTs. Evaluation results show that a 7-input SLM-based vFPGA can reduce LUT and flip-flop resource usage by up to 32% and 35% on an Artix-7 FPGA, 30% and 35% on a Kintex-7 FPGA, and 30% and 35% on a Kintex UltraScale+ FPGA respectively, as compared to a LUT-based vFPGA of the same input size.
A wideband low-jitter PLL with an optimized Ring-VCO

A wideband low-jitter phase-locked loop (PLL) is proposed to provide high performance clocks for the transceivers. The ring voltage-controlled oscillator (Ring-VCO) is a key component of a PLL, which directly determine the out-band phase noise and output frequency range of the PLL. Therefore, a low phase noise two-stage Ring-VCO with a novel delay cell is proposed to help achieve a wideband low-jitter PLL. An accumulation-mode MOS (AMOS) varactor pair is adopted in the delay cell to improve the ﬁ ne tuning linearity. Moreover, an additional AMOS varactor pair is employed to reduce the VCO gain variation in the coarse tuning process and enhance the tolerance in temperature and voltage variations. Implemented in a conventional TSMC 180nm CMOS process, the proposed Ring-VCO can tune from 0.73 to 1.92GHz and the worst-case phase noise at 1MHz o ﬀ set is − 102dBc / Hz. The output frequency range of the proposed PLL is 0.06 – 1.92GHz and the RMS jitter is less than 3.8ps over the whole working band.
Simulation study of an ultra-low specific on-resistance high-voltage pLDMOS with self-biased accumulation layer

In this letter, a high-voltage p-channel Lateral Diffused Metal Oxide Semiconductor Transistor (pLDMOS) with self-biased accumulation layer is proposed. A poly-silicon layer is formed on the thin insulator layer , which locates at the surface of the P-drift region. During on-state, an automatically obtained negative voltage is applied on the poly-silicon to induce a hole accumulation layer at the surface of the P-drift region. Therefore, the specific on-resistance ( R on,sp ) can be significantly reduced. Moreover, the permittivity of the gate insulator on the P-drift can be increased by selecting different insulator materials. Thus, the R on,sp can be further reduced due to more holes being accumulated at the surface of the P-drift. The simulation results shows that the R on,sp of the proposed pLDMOS can be dramatically reduced by 62.3% to 82.5% compared with that of the p-type Triple RESURF silicon limit. For the proposed pLDMOS, the transient Figure of Merit (FOM) is significantly improved by several to 10 times and the static Figure of Merit (FOM) is improved by several times compared with those of an Extended Gate pLDMOS (EG-pLDMOS) and a conventional pLDMOS.
UEC at TRECVID 2016 AVS task

In this report we describe our approach and results for the Ad-hoc Video Search (AVS) task at TRECVID2016. We used deep convolutional neural network features extracted with the VGG-16 network, and took very simple approach just by training SVM detector for each event. As a result we achieved the 0.005 mean average precision.
Invariant set-based robust fault detection and optimal fault estimation for discrete-time LPV systems with bounded uncertainties

ABSTRACT This paper proposes an invariant set-based robust fault detection (FD) and optimal fault estimation (FE) method for discrete-time linear parameter varying (LPV) systems with bounded uncertainties. Firstly, a novel invariant-set construction method for discrete-time LPV systems is proposed if and only if the system is poly-quadratically stable, which need not satisfy the condition that there must exist a common quadratic Lyapunov function for all vertex matrices of the system compared to the traditional invariant-set construction methods. Furthermore, by using a shrinking procedure, we provide minimal robust positively invariant (mRPI) set approximations that are always positively invariant at each step of iteration and allow a priori desired precision to obtain a high sensitivity of FD. Owing to the existence of invariant set-based FD phase, the assumption that the initial faults should be bounded by a given set can be avoided for FE. We compute an optimal parametric matrix gain by minimising the Frobenius norm-based size of the corresponding FE set to obtain the optimal FE performance. Theoretically, any trajectory in the FE tube can be chosen as a specific-value estimation for the real fault signals. Finally, a vehicle dynamics system is used to illustrate the effectiveness of the proposed method.
Ultra-Rapid, Unexpected, and Full Remission of Manic Episode afterTreatment with Haloperidol High Doses 2 Case Reports

Bipolar disorder is a psychiatric condition that can develop severe manic episodes which can be life threatening for patient or others and therefore rapid intervention is required to prevent this. Antipsychotic treatment with FGAs (first generation antipsychotics) is still frequently used for quick sedative effect as well as for the improvement of manic symptoms. Management of agitation in patients with psychiatric disorders is a major problem in acute psychiatric settings with insufficient personnel, situation which is frequent in Romania and other East European countries. FGAs (first generation antipsychotics) and BDZ (benzodiazepine), especially as intramuscular formulation, alone or in combination, have been the treatment choice for extreme agitation and aggression all over the world. Haloperidol is still used to treat schizophrenia and acute psychosis as well as agitation, extreme aggression and manic episode. It is known that common adverse effects include extrapyramidal reactions, restlessness, neuroleptic malignant syndrome, and tremor. High doses of haloperidol are administered to patients when RT (rapid tranquilization) is needed. We present two cases of unusual, unexpected, ultrafast and full remission of a manic episode after treatment with haloperidol high doses.
Triggers of Social Network Collapse

ABSTRACT Modern social networks are characterized by highly connected structures that reflect a variety of social interrelations. In the given research, we focus on the quantitative analysis of social networks in terms of their sustainability. Based on the symbiosis of game theory, network analysis, and decision theory, we introduce an interdisciplinary approach for the detection of agents that have the potential social power to trigger the dissolution processes in networks.
A novel method to test and optimize the periphery crosstalk in CMOS image sensor

For the purpose of reducing the peripheral crosstalk occur in the edge pixel, we illustrated a method to test and quantify the intensity of this crosstalk, and setup a model combining the opposite incident light and color construction. With the aid of the method and model, we conducted many experiments to analyze and compare the improvement measures, finding that the increase of pixel edge to package edge distance, sealing glass thinning and black photoresist coating around edge are all effective to reduce the peripheral crosstalk. Moreover, considering the effect and cost, the sealing glass thinning is the relatively best measure
A coaxial dual-receiver wireless power transfer system with bipolar coils to eliminate cross-coupling and achieve a controllable power distribution

This paper proposes a dual-receiver wireless power transfer system that uses bipolar coils as a transmitter and receivers. Compared with a traditional dual-receiver system with unipolar coils, the proposed system can e ﬀ ectively and conveniently eliminate cross-coupling between the receivers, and another signi ﬁ cant feature of the system is the ease of changing the received power of the two receiver loads by changing the relative angle of the bipolar coils. The mutual inductance of the bipolar coils is modelled by Newman ’ s formula. Then a system design method to eliminate the in ﬂ uence of cross-coupling and realize controllable power allocation is proposed.
Stability of switched positive linear delay systems with mixed impulses

ABSTRACT This paper investigates the global exponential stability of both continuous-time and discrete-time switched positive linear delay systems with the coexistence of destabilising and stabilising impulses. Based on the comparison principle, with the help of discretised multiple linear copositive Lyapunov functions, some delay-independent stability results are obtained. It should be noted that it is the first time that discrete-time switched delay systems with asynchronous switching and impulses are considered, and the switching effect can be stabilising in the obtained results of this paper. Some numerical examples are provided to demonstrate the effectiveness and superiority of the derived results.
Informedia @ TRECVID 2016

We report on our system used in the TRECVID 2016 Multimedia Event Detection (MED) and Ad-hoc Video Search (AVS) tasks. On the MED task, the CMU team submitted runs in 000Ex, 010Ex and 100Ex settings for the Pre-specified Events. On the AVS task, the CMU team submitted runs for fully-automatic system with no annotation condition.
A synchronous driving approach based on adaptive delay phase-locked loop for stitching CMOS image sensor

A synchronous driving approach for stitching CMOS image sensor is proposed. Dual terminal signal line driver structure must be considered in the design of row control for high de ﬁ nition CMOS image sensor pixel array. However, as the size of the array increases further, the traditional synchronization technologies such as clock tree cannot be applied because of the stitching technology. Furthermore, this invalidity will cause DC shoot through and dead line. Based on the adaptive delay phase-locked loop, dual terminal signal line driver with highly e ﬃ cient synchronization for pixel array is realized in a single die CMOS image sensor with 225M pixels and large area of 120 × 120mm 2 . The compar-ison results show that the timing matching improves by two orders of magnitude, and the consistency reaches 99.95%.
Proactive useless data flush architecture for nonvolatile SRAM using magnetic tunnel junctions

A store energy and latency reduction architecture based on proactive useless data ﬂ ush (PUDF) is proposed for nonvolatile SRAM (NV-SRAM) using magnetic tunnel junctions (MTJs). Prior to the store operation to the MTJs in the array, the PUDF architecture predicts store-unneeded blocks having useless data and shuts down these blocks in advance. As a result, the store energy and latency can be reduced depending on the proportion of store-unneeded blocks, which enhances the energy reduction e ﬃ ciency of power gating (PG) using the NV-SRAM. The energy and latency characteristics are computationally analysed and experimentally veri ﬁ ed using circuit parameters extracted from fabricated test-element-group (TEG) circuits of the NV-SRAM.
A 100-M/s 2.6-pJ/pulse compact UWB impulse transmitter based on antenna-and-pulse-generator codesign

This work presents a novel concept of antenna-and-pulse- generator codesign for realizing FCC-regulation-compliant IR-UWB transmitters. The method contributes to a compact design that significantly reduces the overall device footprint and energy consumption. A Gaussian mono-pulse generator and a folded-dipole antenna with a bandwidth of 7.8-9.5 GHz are co-optimized, eliminating any matching sections. The energy consumption for each impulse emission is only 2.6 pJ and 100 Mpulse/s operation of the transmitter complies with the FCC mask. The transmitter of this kind shows promise for size-restricted and ultra-low power applications such as implants.
Subword Segmentation for Machine Translation Based on Grouping Words by Potential Roots

This paper proposes a new subword segmentation method for machine translation. The algorithm, which we call GenSeg, is generic in the sense that it can be applied to any language, but is designed with an emphasis on inflectional splitting, i.e. it attempts to split words on boundaries corresponding to inflectional suffixes. The main principle of the method is grouping together words that share a common middle substring, and then separating the best such substring from the rest of the word. GenSeg is a cross-language method extended with some language-specific morphological analysis rules (currently for the Latvian language). To verify its effectiveness, we performed machine translation experiments in two directions: Latvian-English and EnglishLatvian, obtaining minor improvements in translation quality when using our pre-processing method.
Performances of SD Bioline Malaria Ag-P.F/Pan RDT for the Diagnosis of Malaria in Febrile Patients Living In Gabon, Central Africa

The SD Bioline malaria Ag- Pf/Pan performances were evaluated for malaria species detection in 215 febrile patients living in Gabon, using microscopy as gold standard. Malaria parasites were identified in 94 (43.7%) individuals by microscopy, and 104 (48.4%) patients tested positive by the RDT. The SD Bioline Ag-Pf/Pan global sensitivity was 96.8%. All the non-falciparum malaria species infections were correctly diagnosed by the rapid test. The specificity was of 89.3% and the false positive (FP) rate of 12.5%. The test sensitivity significantly increased with parasitaemia, being of 88.9% for parasite density below 100/ µL and 98.5% at density higher than 500 parasites/ µL (p<0.01). Among the patients with a negative blood smear, the proportion of FP results was 21.0% in those previously-treated with an antimalarial drug before the consultation, and 8.8% in individuals without self-medication. SD Bioline Ag-Pf/ Pan RDT represents a good alternative to microscopy for the diagnosis of Plasmodium spp infection.
Magnaporthe oryzae fimbrin organizes actin networks in the hyphal tip during polar growth and pathogenesis

Magnaporthe oryzae causes rice blast disease, but little is known about the dynamic restructuring of the actin cytoskeleton during its polarized tip growth and pathogenesis. Here, we used super-resolution live-cell imaging to investigate the dynamic organization of the actin cytoskeleton in M. oryzae during hyphal tip growth and pathogenesis. We observed a dense actin network at the apical region of the hyphae and actin filaments originating from the Spitzenkörper (Spk, the organizing center for hyphal growth and development) that formed branched actin bundles radiating to the cell membrane. The actin cross-linking protein Fimbrin (MoFim1) helps organize this actin distribution. MoFim1 localizes to the actin at the subapical collar, the actin bundles, and actin at the Spk. Knockout of MoFim1 resulted in impaired Spk maintenance and reduced actin bundle formation, preventing polar growth, vesicle transport, and the expansion of hyphae in plant cells. Finally, transgenic rice (Oryza sativa) expressing RNA hairpins targeting MoFim1 exhibited improved resistance to M. oryzae infection, indicating that MoFim1 represents an excellent candidate for M. oryzae control. These results reveal the dynamics of actin assembly in M. oryzae during hyphal tip development and pathogenesis, and they suggest a mechanism in which MoFim1 organizes such actin networks.
Cell cycle transcriptomics of Capsaspora provides insights into the evolution of cyclin-CDK machinery

Progression through the cell cycle in eukaryotes is regulated on multiple levels. The main driver of the cell cycle progression is the periodic activity of cyclin-dependent kinase (CDK) complexes. In parallel, transcription during the cell cycle is regulated by a transcriptional program that ensures the just-in-time gene expression. Many core cell cycle regulators are widely conserved in eukaryotes, among them cyclins and CDKs; however, periodic transcriptional programs are divergent between distantly related species. In addition, many otherwise conserved cell cycle regulators have been lost and independently evolved in yeast, a widely used model organism for cell cycle research. For a better understanding of the evolution of the cell cycle regulation in opisthokonts, we investigated the transcriptional program during the cell cycle of the filasterean Capsaspora owczarzaki, a unicellular species closely related to animals. We developed a protocol for cell cycle synchronization in Capsaspora cultures and assessed gene expression over time across the entire cell cycle. We identified a set of 801 periodic genes that grouped into five clusters of expression over time. Comparison with datasets from other eukaryotes revealed that the periodic transcriptional program of Capsaspora is most similar to that of animal cells. We found that orthologues of cyclin A, B and E are expressed at the same cell cycle stages as in human cells and in the same temporal order. However, in contrast to human cells where these cyclins interact with multiple CDKs, Capsaspora cyclins likely interact with a single ancestral CDK1-3. Thus, the Capsaspora cyclin-CDK system could represent an intermediate state in the evolution of animal-like cyclin-CDK regulation. Overall, our results demonstrate that Capsaspora could be a useful unicellular model system for animal cell cycle regulation.