Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimizing the detection of hereditary non-polyposis colorectal cancer: An update

Hereditary non-polyposis colorectal cancer (HNPCC) is a dominant inherited disease and accounts for up to 5% of all colorectal cancer (CRC) patients. Despite the optimization of selection criteria and enhancements in molecular techniques for identifying more families with HNPCC, most cases are not recognized. Poor patient recollection of family history and inadequate family history-taking are main causative factors. We propose a new strategy for detecting HNPCC, one in which the pathologist selects patients for microsatellite instability (MSI) testing. Criteria for MSI analysis are: (1) CRC before the age of 50 years, (2) second CRC before 70 years, (3) CRC and HNPCC-associated cancer before 70 years, or (4) adenoma before 40 years. Additionally, patients with a positive MSI test and patients with a positive family history are offered referral for genetic counselling. With this strategy, at least twice the number of HNPCC patients will be identified among a population of CRC patients, and in a cost-effective, efficient and feasible way. The identification of patients with HNPCC is important because intensive surveillance can prevent death from CRC.
Simultaneous detection of three transgenic events in crops using multiplex polymerase chain reaction (PCR)

In spite of all advantages for using end-point polymerase chain reaction (PCR) this technique can onlyshows a limiting: only is possible to detect one gene DNA sequence by reaction. However multiplex PCR has been proposed for employing in the detection of two or more DNA sequences or genes. This implies sometimes savinge time and money. The objective of this study was to adapt the multiplex PCR technique for detection off the either two or three of the most common transgenic genes present in different plants. The DNA was isolated from maize, soybean and cotton plants. The optimization of the multiplex PCR was performed changing the concentration of MgCl2, primer annealing temperature and primer design. With this optimization it was possible to amplify three genes (cry 1Ab, epsps and als) in same reaction of PCR. These results may lead to icreasedincreased efficienceefficiency in have an impact more efficient on detection of genetically modified organisms. Key words: Multiplex polymerase chain reaction (PCR), cry 1Ab, epsps, als.
SVM-based moisture content modelling for Sugi drying process

In this paper, moisture content modelling method based on support vector machine for Sugi drying process is proposed. Moisture content is the quantity of water contained in the Sugi. In general, water in Sugi can be presented as free water and bound water. Sugi drying process refers to reduce the process of Sugi moisture content which is mainly determined by drying temperature and equilibrium moisture content. It is complex nonlinear relationship among them such that theoretical modelling could not be obtained to describe accurately them. As for a nonlinear modelling technique based on statistical learning theory, support vector machine aims at the achievement of high estimating accuracy. As a result, a new moisture content model for Sugi drying process is proposed by using support vector machine technique, including free moisture content model and bound moisture content model. Also, infinite impulse response filter technology is considered to filter the estimating output. Simulation results are given to show the effectiveness of the proposed method compared with moisture content modelling method based on least square technique.
Localization and analysis of bovine papillomavirus type 1 transforming functions

Bovine papillomavirus type 1 (BPV-1) or cloned BPV-1 DNA can transform susceptible rodent cells, and the viral DNA remains as a stable extrachromosomal plasmid in the transformed cells. The transforming region of the BPV-1 genome has previously been localized to a specific fragment comprising 69% of the genome, which also contains the elements sufficient for extrachromosomal plasmid maintenance. To define more precisely the viral DNA sequences which are involved in cellular transformation, we have tested the ability of defined deletion mutants of BPV-1 DNA to morphologically transform mouse C127 cells. Cells containing the mutated DNAs have been examined for anchorage independence and tumorigenicity in nude mice. Several distinct regions of the BPV-1 genome were found to influence expression of the viral transformation functions. A transcriptional regulatory region located in the noncoding region 5' to the early open reading frames is essential for transcriptional activity and transformation. A transcriptional enhancer element, located 3' to the polyadenylation site for the viral RNAs expressed in transformed cells, has previously been shown to be essential for transformation (Lusky et al., Mol. Cell. Biol., 3:1108-1122, 1983). Deletion mutants affecting the E2 open reading frame, particularly the NH2 half, are significantly impaired in their ability to transform, suggesting that the E2 gene product is an important transforming protein of BPV-1. Mutants lacking the E6 and E7 open reading frames are still able to induce transformation but at a lowered efficiency, and the transformants have altered characteristics. Mutations localized within the E1 open reading frame do not significantly affect the transforming functions but result in the integration of the viral genome in the transformed cells, implicating the E1 gene product in stable plasmid replication and maintenance.
Consistent modeling of capacitances and transit times of GaAs-based HBTs

This paper investigates how time delays and capacitances observed under small-signal conditions can be consistently accounted for in heterojunction bipolar transistor (HBT) large-signal models. The approach starts at the circuit level by mapping the large-signal equivalent circuit (which consists of charge and current sources) to the well-known small-signal circuit (which consists of capacitances, transit-time, and resistances). It is shown that and how bias dependent charge sources at either pn-junction impact transit-time, base-collector capacitance, and their mutual dependence. It is demonstrated for the example of a GaAs-based HBT that the interrelation of the elements is observed in measurements as predicted. The results of the investigation enhance understanding of HBT model characteristics and provide a criterion to check model consistency.
A Combined Approach to Emotion Detection in Suicide Notes

In this paper, we present the system we have developed for participating in the second task of the i2b2/VA 2011 challenge dedicated to emotion detection in clinical records. On the official evaluation, we ranked 6th out of 26 participants. Our best configuration, based upon a combination of both a machine-learning based approach and manually-defined transducers, obtained a 0.5383 global F-measure, while the distribution of the other 26 participants’ results is characterized by mean = 0.4875, stdev = 0.0742, min = 0.2967, max = 0.6139, and median = 0.5027. Combination of machine learning and transducer is achieved by computing the union of results from both approaches, each using a hierarchy of sentiment specific classifiers.
Classification of voiceless speech using facial muscle activity and vision based techniques

This paper presents a silent speech recognition technique based on facial muscle activity and video, without evaluating any voice signals. This research examines the use of facial surface electromyogram (SEMG) to identify unvoiced vowels and vision-based technique to classify unvoiced consonants. The moving root mean square (RMS) of SEMG signals of four facial muscles is used to segment the signals and to identify the start and end of a silently spoken vowels. Visual features are extracted from the mouth video of a speaker silently uttering consonants using motion segmentation and image moment techniques. The SEMG features and visual features are classified using feedforward multilayer perceptron (MLP) neural networks. The preliminary results demonstrate that the proposed technique yields high recognition rate for classification of unvoiced vowels using SEMG features. Similarly, promising results are obtained in identification of consonants using visual features. The results demonstrate that the system is easy to train for a new user and suggest that such a system works reliably for voiceless, simple speech based commands for human computer interface when it is trained for a user.
Alcohol and the reward value of cigarette smoking

People who drink alcohol are more likely to smoke, and experiments have shown that alcohol can increase cigarette smoking. However, it is not clear why alcohol consumption should increase smoking. To address this issue the current experiment looked at the effects of alcohol on a range of behavioural and subjective measures intended to assess the reward value of smoking. These included a preference test carried out after subjects had smoked cigarettes of one colour after consuming alcohol, and cigarettes of another colour after consuming non-alcoholic drinks. In the preference test, subjects were offered the choice of smoking the alcoholic or non-alcoholic drink-paired cigarette. It was hypothesised that if alcohol increased the reward value of smoking, subjects would choose to smoke the alcohol-paired cigarette. Consumption of alcohol increased the length of time people spent smoking, increased the number of puffs taken on each dgarette, and increased the amount of tobacco burnt There were also strong subjective effects, with subjects looking forward more to smoking after alcohol and reporting greater smoking satisfaction after alcohol However, subjects did not show a preference for the cigarettes they had smoked after alcohol.
Development of a self-adaptive Web search engine

As the Web evolves towards the direction of providing more and more information, locating the desired information efficiently becomes a very important issue. Web search engines are very useful information search tools in the Internet. Current Web search engines produce search results relating to the search terms and the actual information collected by them. Since the selections of the search results cannot affect the future ones, they may not cover most people's interests. Feedback information produced by users' accessing lists can influence the search results. Thus the search engines can provide self-adaptability.
Social Roles, Basic Need Satisfaction, and Psychological Health

The authors propose that competence need fulfillment within valued role domains (i.e., spouse, parent, worker) will account, in part, for associations between autonomy and relatedness need fulfillment and psychological health. Testing these assertions in cross-sectional and longitudinal surveys of women in two independent community samples, the findings are the first to formally examine whether the satisfaction of competence needs within social roles accounts for associations between other types of need satisfaction and affective outcomes as well as depressive symptomology. Evidence supporting the hypothesis was stronger when examining individuals’ affective health as compared to their depressive symptoms. Implications of the findings are discussed with regard to need fulfillment within social roles.
A Multi-Layer System for Semantic Textual Similarity

Building a system able to cope with various phenomena which falls under the umbrella of semantic similarity is far from trivial. It is almost always the case that the performances of a system do not vary consistently or predictably from corpora to corpora. We analyzed the source of this variance and found that it is related to the word-pair similarity distribution among the topics in the various corpora. Then we used this insight to construct a 4-module system that would take into consideration not only string and semantic word similarity, but also word alignment and sentence structure. The system consistently achieves an accuracy which is very close to the state of the art, or reaching a new state of the art. The system is based on a multi-layer architecture and is able to deal with heterogeneous corpora which may not have been generated by the same distribution.
Effect of 3-amino-1,2,4-triazole on the stimulation of hepatic microsomal heme synthesis and induction of hepatic microsomal oxidases produced by phenobarbital.

3-Amino-1,2,4-triazole inhibits rat hepatic δ-aminolevulinic acid dehydratase (EC [4.2.1.24][1]), the enzyme which mediates the second step in heme biosynthesis. Aminotriazole decreases the incorporation of both δ-aminolevulinic acid-14C and 59Fe into microsomal heme and inhibits the stimulation of 59Fe incorporation into microsomal heme produced by phenobarbital. Aminotriazole also inhibits the induction of rat hepatic microsomal cytochrome P-450 and that of the microsomal oxidations of ethylmorphine, norcodeine, and 3-methyl-4-monomethylaminoazobenzene produced by phenobarbital during the first 48 hr of treatment. Since aminotriazole has no effect on the induction of the hepatic microsomal flavoprotein NADPH-cytochrome c reductase by phenobarbital, it appears to inhibit the biosynthesis of heme exclusive of an effect on protein synthesis. It is suggested that heme synthesis may be the controlling event in the synthesis of the microsomal hemoprotein cytochrome P-450, and that stimulation of heme synthesis represents one means by which phenobarbital produces an increase of cytochrome P-450 in hepatic microsomes. [1]: pending:yes
Central Line-Associated Bloodstream Infections in Non-ICU Inpatient Wards: A 2-Year Analysis

OBJECTIVE Little is known about patient-specific factors contributing to central line-associated bloodstream infection (CLABSI) outside of the intensive care unit (ICU). We sought to describe these factors and hypothesized that dialysis patients would comprise a significant proportion of this cohort. DESIGN Retrospective observational study from January 2010 to December 2011 SETTING An 880-bed tertiary teaching hospital PATIENTS Patients with CLABSI in non–ICU wards METHODS CLABSI patients were identified from existing infection-control databases and primary chart review was conducted. National Health and Safety Network (NHSN) definitions were utilized for CLABSI and pathogen classification. CLABSI rates were calculated per patient day. Total mortality rates were inclusive of hospice patients. RESULTS Over a 2-year period, 104 patients incurred 113 CLABSIs for an infection rate of 0.35 per 1,000 patient days. The mean length of hospital stay prior to CLABSI was 16±13.3 days, which was nearly 3 times that of hospital-wide non-ICU length of stay. Only 11 patients (10.6%) received dialysis within 48 hours of CLABSI. However, 67% of patients had a hematologic malignancy, and 91.8% of those admitted with a malignant hematologic diagnosis were neutropenic at the time of CLABSI. Enterococcus spp. was the most common organism recovered, and half of all central venous catheters (CVCs) present were peripherally inserted central catheters (PICC lines). Mortality rates were 18.3% overall and 27.3% among dialysis patients. CONCLUSIONS In patients with CLABSIs outside of the ICU, only 10.6% received dialysis prior to infection. However, underlying hematologic malignancy, neutropenia, and PICC lines were highly prevalent in this population. Infect Control Hosp Epidemiol 2015;00(0):1–7
Whole-Genome Sequence of Enterobacter sp. Strain SST3, an Endophyte Isolated from Jamaican Sugarcane (Saccharum sp.) Stalk Tissue

ABSTRACT Enterobacter sp. strain SST3 is an endophytic bacterium isolated from Saccharum spp. Here we present its annotated draft genome that may shed light on its role as a bacterial endophyte of sugarcane. To our knowledge, this is the first genome announcement of a sugarcane-associated bacterium from the genus Enterobacter.
Impact of Mode of Delivery on Outcomes in Patients with Perianal Crohn's Disease

Background:Crohn's disease (CD) often affects women during the reproductive years. Although several studies have examined the impact of pregnancy on luminal disease, limited literature exists in those with perianal CD. Decision regarding mode of delivery is a unique challenge in such patients due to concerns regarding the effect of pelvic floor trauma during delivery on preexisting perianal involvement. Methods:We performed a retrospective chart review of patients with CD with established perianal disease undergoing either vaginal delivery or caesarean section (C-section) at our institutions. We examined the occurrence of symptomatic perianal disease flares within 5 years after delivery in such women compared with nonpregnant CD controls. We also compared the occurrence of such flares between the 2 modes of delivery in women with established perianal CD. Results:We identified 61 pregnant patients with CD with established perianal disease (11 vaginal delivery, 50 through C-section) and 61 nonpregnant CD controls with perianal disease. One-third of the C-sections were primarily for obstetric indications. Six of the vaginal deliveries were complicated. Approximately, 36% of cases had a symptomatic perianal flare within 1 year after delivery. This was similar across both modes of delivery (P = 0.53) and similar to nonpregnant patients with CD. There was no difference in the rates of perianal surgical intervention or luminal disease flares in our population based on mode of delivery or between pregnant patients with CD and nonpregnant CD controls. Conclusions:We observed no difference in risk of symptomatic perianal flares in patients with established perianal CD delivering vaginally or through C-section.
Wireless Anomaly Detection based on IEEE 802 . 11 Behavior Analysis

In this article, we portray an variance according to the intrusion finding system for the IEEE 802.11 wireless networks based on behavioral study to sense deviations from usual behaviors that are triggered by wireless network attacks. Our anomaly behavior study of the 802.11 protocols is based on monitoring the nconsecutive evolutions of the etiquette state machine. Keywords— wireless ,anomaly detection, malware
Research on bank intelligent video image processing and monitoring control system based on OpenCV

As the principal place for currency flow nowadays, the banking system plays a special role in society and its security has always been a focus. The current bank branches' security systems usually use video surveillance system, which is basically used to provide evidence after incidents, and it can not do real-time warning. With the rapid development of computer vision, video and intelligent recognition, real-time alarm analysis of surveillance system has become possible. Based on the technologies of human body detection, motion tracking and behavior judgement, this article designs a bank intelligent video image processing and monitoring control system which is based on OpenCV, and the system not only realizes real-time monitoring and alarm within monitoring zone effectively, but also brings innovations to the traditional video surveillance system, providing strong protection of safe operation for banks.
Neoadjuvant therapy offers longer survival than upfront surgery for poorly differentiated and higher stage pancreatic cancer

Abstract Background: Neoadjuvant therapy for pancreatic cancer remains controversial. Our aim was to assess differences in survival, disease recurrence and histopathological tumor characteristics between patients treated with neoadjuvant therapy followed by subsequent surgery and patients undergoing upfront surgery. Material and methods: Out of 399 consecutive pancreatic ductal adenocarcinoma (PDAC) patients operated at Helsinki University Hospital in 2000–2015, 75 borderline resectable patients were treated with neoadjuvant therapy. Resectable propensity scored patients (n = 150) underwent upfront surgery. Neoadjuvant therapy consisted of folfirinox, single gemcitabine or combined with cisplatin, nab-paclitaxel or capecitabine with or without radiation. Survival was calculated with Kaplan–Meier and compared with the Breslow test. Survival was determined from the start of treatment, being the first day of treatment for patients treated with neoadjuvant therapy and the date of surgery for others. Results: Between 2000 and 2015 median disease-specific survival (DSS) [34 vs. 26 months, p = . 016] and disease-free survival (DFS) [22 vs. 13 months, p = . 001] were longer in patients treated with neoadjuvant therapy than in those undergoing upfront surgery. Survival differences were not significant in the 2000s but were, in turn, among patients treated in the 2010s with better survival for patients treated with neoadjuvant therapy [DSS 35 vs. 26 months, p = . 008 and DFS 25 vs. 13 months, p = . 001]. Especially patients with poorly differentiated G3 tumors [DSS 30 vs. 11 months, p = . 004 and DFS 21 vs. 7 months, p = . 001] and higher stage IIB–III [DSS 34 vs. 20 months, p = . 006 and DFS 21 vs. 10 months, p = . 001] had longer survival when treated with neoadjuvant therapy. Conclusions: PDAC patients treated with neoadjuvant therapy had longer DSS and DFS than those undergoing upfront surgery. Neoadjuvant therapy benefits especially borderline resectable patients with higher stage and poorly differentiated tumors.
Research on Conflict Resolution and Consistency Maintenance Supporting Intention Combination in Real-time Collaboration Environment

With the real-time group editing system, a group of users can view and edit the shared document by communication networks anytime and anywhere. Under the circumstance, it is surely inevitable that many operations from different users are going to conflict. Thus, two issues, the conflict resolution and the consistency maintenance, are the most important for designing and completing the system. In the past, the address space transformation algorithm, invented from the research about the real-time text editing system, could maintain consistency among more sites. The Multi Version conflict resolution approach could preserve users’ intentions but not all when conflicts occur. This paper proposes a new solution of conflict resolution, named Intention Combination Conflict Resolution strategy with the document model of AST based on the idea of Multi Version approach. This solution can not only preserve all users’ editing consistency by intention combination, but also keep all versions of operational objects including conflict operations’ combination effects. In addition, the effectiveness of related algorithms is analyzed, and the availability of the strategy is described by a case and proved by our experiment.
Executive functions in attention-deficit/hyperactivity disorder.

OBJECTIVE To examine the association between weaknesses in executive functions and attention-deficit/hyperactivity disorder (ADHD). METHOD Empirical studies examining executive functions in ADHD samples were reviewed, with particular attention to results of recent meta-analyses. RESULTS ADHD is associated with impaired performance on measures of response inhibition, working memory, and other aspects of executive functions, yet data also suggest significant neuropsychological variability within and across ADHD samples. CONCLUSION ADHD may be best conceptualized as a neuropsychologically heterogeneous condition. More work is needed to characterize this heterogeneity and its clinical and pathophysiologic implications.