Miracle-dz/UniFAR-FTUs huggingface dataset:
Diagnostic and Prognostic Value of RNA-Proteolipid in Sera of Patients with Malignant Disorders following Therapy: First Clinical Evaluation of a Novel Tumor Marker1

The circulating level of a novel RNA-proteolipid complex associated with malignant diseases was critically evaluated as a tumor marker in clinical oncology. The complex, isolated from the sera of cancer patients, exhibited unvarying chemical composition regardless of the cell type and clinical staging. Clearance from blood was rapid with a half-life of approximately 2 days. Tumor mass could be correlated with the circulat ing level. After effective treatment the level fell and rose again 10 months prior to the conventional clinical diagnosis of relapse.
Plant Biotechnology 23, 535–538 (2006)

The nuclear matrix attachment region (MAR) located upstream from the tobacco gene CHN50, designated CHN50MAR, consists of two MAR elements: S/M I and S/M II. In a direct gene transfer system using tobacco BY-2 cells, CHN50MAR produced a several-fold increase in colony formation of hygromycin-resistant (hyg) cells when arranged adjacent to both the 5 and 3 termini of a hygromycin-selective marker gene. S/M I and S/M II enhanced hyg colony formation to the same degree as CHN50MAR, suggesting that these MAR elements are functionally redundant for enhancing transformation. The presence of the marker genes in the hyg cells was confirmed using the polymerase chain reaction. These results imply that CHN50MAR and its MAR elements are available as transformation enhancers in direct gene transfer systems for plants.
CRF-based depth refinement with hybrid depth information

A conditional random field (CRF)-based framework is proposed for depth refinement. It consists of two phases: depth impainting and depth super-resolution (SR). The CRF inference procedure uses depth information enhanced in three different ways to ensure the accurate edge of the final depth output. The experimental results show the effectiveness of the method both numerically and visually. Note that the method produces depth map with better edge than other depth impainting and SR methods do.
Alchemilla persica’nın Farklı Polaritelerdeki Ekstraktlarının Antisitotoksik, Antioksidan ve Antimikrobiyal Aktivitelerinin Belirlenmesi

Anahtar Kelimeler Alchemilla persica, Antisitotoksik, Antioksidan, Antimikrobiyal, Bitki Ekstraktları Öz: Alchemilla persica, hekzan, diklorometan, etil asetat, metanol ve su gibi artan polariteye sahip çözücülerde farklı polaritelere sahip bitki özleri elde edildi. Antioksidan aktivitenin belirlenmesinde toplam fenol içeriği, toplam flavonoid içeriği ve likopen içeriği etil asetat, fenolik asit içeriği hegzan ekstraktında; β–karoten içeriği metanol ekstraktında diğer ekstraktlara göre yüksek olarak belirlenmiştir. Toplam antioksidan aktivite, DPPH serbest radikal giderme aktivitesi, metal şelatlama kapasitesi, toplam indirgeme gücü, hidrojen peroksit giderme, hidroksil radikal uzaklaştırma aktiviteleri farklı konsantrasyonlarda belirlenmiştir. Antimikrobiyal aktivitenin belirlenmesinde agar disk difüzyon tekniği kullanıldı. Antimikrobiyal testlerde, Alchemilla persica'nın diklorometan ekstraktı, en yüksek aktiviteye sahip ekstrakt olarak belirlendi. Etil asetat ekstresinin antimikrobiyal özelliği, diklorometan ekstraktına hemen hemen benzerdi. Bu ekstraktları antimikrobiyal değerlendirmede metanol ve su ekstreleri izledi. Alchemilla persica'nın farklı özütleriyle yapılan antioksidan çalışmaları sonucunda, α-tokoferol, BHA, BHT ve Trolox gibi standart antioksidanlardan daha etkili olduğu bulunmuştur. Bitki ekstraktlarından su ve metanol ekstraktları anti-sitotoksik etki için çalışılmış ve bu ekstraktlar farklı konsantrasyonlarda hücre büyümesini engellemiştir. Çalışmada elde edilen sonuçlar bu Alchemilla persica türüne ait ekstrelerin antioksidan, antimikrobiyal ve antisitotoksik etki gösterdiği belirlenmiştir.
Development of Fuzzy Logic model for Project Management Success (PMS)

The most critical and challenging task of Project Manager in an organization is the successful management of projects. However, failure in managing projects is encountered regularly, which causes waste of company resources. The aim of this research is to simultaneously optimise the time, the cost, the quality, the scope and the PMS of a project and hence providing an aid to project manager in taking effective decisions. In this paper a Fuzzy logic Matlab model for PMS is developed. A stage wise fuzzy reasoning approach is used as it reduces the fuzzy if-then rules making the system less complex. A set of examples are given at the end to show the applicability and validity of the proposed methodology.
The value of standards and labelling: an international cost-benefit analysis tool for Standards & Labelling programs with results for Central American countries

We describe a cost-benefit spreadsheet analysis tool that provides an evaluation of the net impacts of an appliance standards and labelling (S&L) program. The tool is designed to provide a rough estimate at very low cost to local analysts, while allowing for a more accurate evaluation when detailed local data are available. The methodology takes a bottom-up engineering approach, beginning with appliance-specific engineering parameters relating efficiency improvement and incremental costs associated with specific design technologies. Efficiency improvement afforded by each potential policy option is combined with local appliance use patterns to estimate average annual energy consumption for each appliance. This information is combined with appliance lifetime data and local energy prices to provide a life cycle cost impact assessment at the household level. In addition to household level impacts, the analysis tool forecasts future appliance sales, in order to calculate potential energy savings, consumer financial impacts and carbon emissions reductions at the national level. In order to demonstrate the features of the policy model employed, this poster presents a regional analysis based on the most recent publicly available appliance data. In particular, a set of developing countries in Central America were chosen as an example. Taken as a whole, the Central American results demonstrate the general level of benefit which could be afforded in these countries. Comparison between the countries reveals the key parameters determining the benefit a given country can expect from a standards program.
Molecular evolution of non-fertilizing sperm in Lepidoptera suggests minimal direct 1 involvement in sperm competition

27 Sperm are among the most variable cells in nature. Some of this variation results from non-adaptive 28 errors in spermatogenesis, but many species consistently produce multiple sperm morphs, the adaptive 29 significance of which remains unknown. Here, we investigate the evolution of dimorphic sperm in 30 Lepidoptera, the butterflies and moths. Males of this order produce both fertilizing sperm and a 31 secondary, non-fertilizing type that lacks DNA. Previous organismal studies suggested a role for non- 32 fertilizing sperm in sperm competition, but this hypothesis has never been evaluated from a molecular 33 framework. We combined published datasets with new sequencing in two species, the monandrous 34 Carolina sphinx moth and the highly polyandrous monarch butterfly. Based on population genetic 35 analyses, we see evidence for increased adaptive evolution in fertilizing sperm, but only in the 36 polyandrous species. This signal comes primarily from a decrease in non-synonymous polymorphism in 37 sperm proteins compared to the rest of the genome, suggesting stronger purifying selection, consistent 38 with selection via sperm competition. Non-fertilizing sperm proteins, in contrast, do not show an effect 39 of mating system and do not appear to evolve differently from the background genome in either species, 40 arguing against the involvement of non-fertilizing sperm in direct sperm competition. Based on our 41 results and previous work, we suggest that non-fertilizing sperm may be used to delay female remating 42 in these insects and decrease the risk of sperm competition rather than directly affect its outcome. 43 44 45 46 47
Direct submicron patterning of titanium for bone implants

Recent research evidences the strong modulatory role of controlled submicron and nanoscale topographies on stem cells fate. To harness these physical surface cues for clinical applications, fabrication of nanoand submicron patterns on clinically relevant biomaterials is greatly needed. In this study, an electron beam lithography method for direct patterning (i.e., no use of masters/imprinting steps) of titanium in the submicron range was developed. The process required the use of an etch mask consisting of a double layer of SiO2 and Al, and the positive AR P-6200.04 electron beam resist. An optimum electron beam dose of 288 μC/cm was established for writing the desired patterns. The transfer of the patterns into the titanium substrates was achieved by three different steps: inductively coupled plasma etching of the mask in BCl3/Cl2 followed by reactive ion etching of titanium in SF6/CHF3/O2 and a final wet etch of mask residue. Highly ordered arrays of titanium pits with submicron diameters were produced with high reproducibility. This method provides great versatility in pattern design, direct transfer into titanium and increased control of titanium pattern features at submicron to nanoscale enabling clinically relevant and systematic studies on pattern-induced cellular responses.
Hypoglycaemia induced platelet function in T 2 DM

eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs (CC BY-NC-ND) licence. This licence only allows you to download this work and share it with others as long as you credit the authors, but you can’t change the article in any way or use it commercially. More information and the full terms of the licence here: https://creativecommons.org/licenses/
CD 38 Disruption Impairs Glucose-induced Increases in Cyclic ADP-ribose

Increases in [Ca]i in pancreatic beta cells, resulting from Ca mobilization from intracellular stores as well as Ca influx from extracellular sources, are important in insulin secretion by glucose. Cyclic ADP-ribose (cADPR), accumulated in beta cells by glucose stimulation, has been postulated to serve as a second messenger for intracellular Ca mobilization for insulin secretion, and CD38 is thought to be involved in the cADPR accumulation (Takasawa, S., Tohgo, A., Noguchi, N., Koguma, T., Nata, K., Sugimoto, T., Yonekura, H., and Okamoto, H. (1993) J. Biol. Chem. 268, 26052–26054). Here we created “knockout” (CD38) mice by homologous recombination. CD38 mice developed normally but showed no increase in their glucose-induced production of cADPR in pancreatic islets. The glucose-induced [Ca]i rise and insulin secretion were both severely impaired in CD38 islets, whereas CD38 islets responded normally to the extracellular Ca influx stimulants tolbutamide and KCl. CD38 mice showed impaired glucose tolerance, and the serum insulin level was lower than control, and these impaired phenotypes were rescued by beta cell-specific expression of CD38 cDNA. These results indicate that CD38 plays an essential role in intracellular Ca mobilization by cADPR for insulin secretion.
St. Petersburg University Graduate School of Management Master in Management FACTORS AFFECTING CORPORATE ENTREPRENEURSHIP INTENSITY IN RUSSIAN IT COMPANIES Master’s Thesis by the 2nd year student Concentration — MITIM

Master Student's Name Ekaterina Tolmacheva Master Thesis Title Factors affecting corporate entrepreneurship intensity in Russian IT companies Faculty Graduate School of Management Main field of study Corporate entrepreneurship Year 2016 Academic Advisor's Name Professor Galina Shirokova Description of the goal, tasks and main results The goal of the research is to understand how do internal and external factors impact CE in Russian IT companies. Internal factors positively related to CE intensity are high level of complexity, nonmonetary motivation, flexibility of planning and market scope of planning. Internal factors negatively related to CE intensity are high level of formalization and long-term horizon of planning. All external factors, dynamism, heterogeneity and level of rivalry are proved to be positively related to CE intensity.
Modeling Compressive Strength on Mechanical Properties of Concrete Influenced by Partial Replacement of Fine Aggregate with Copper Slag

This paper monitors the variation increase of compressive on partially replacement of copper slag with fine aggregate, the study observed the fluctuation of growth rate of the compressive strength; these were examined to generates the behaviour of the material intermesh of its reaction on strength development, the variation is from the level of compaction, placement and segregation during concrete transport and its placement, including bleeding of concrete that were thoroughly examined. The parameters developed influence based on the fluctuation from the stated parameters that reflects on the growth rates of compressive strength, the derived modeling and simulation monitor the behaviour of concrete properties in different water cement ratios and curing age, the dosage of the addictives were monitor on the simulation, the highest compressive strength were generate at forty percent duration time of twenty eight days of curing, this implies that the replacement of the fine aggregate with copper slag at forty percent developed the optimum compressive strength. The study applied modeling and simulation to monitor other concrete properties that were not considered in the experimental process, this were to determine their variations rate of influence on the compressive strength, the variation of water cement ratios were monitored, the behaviour of the effect on water cement were evaluated, the influence from porosity were also monitor, the study observed reduction of porosity that reflected increase in compressive strength, the simulation subjected the predictive values to validation with experimental values, this was in agreement with the experimental values by Satyanarayana and Saikiran 2019 [1], further study were carried on the existing study whereby the curing age were monitor within 3, 7. and 28days, but 14 days of curing were integrated to monitor the compressive strength of curing age, the generated predictive values were also validated with experimental data, this implies that the develop predictive model can be applied to monitor the growth rate of compressive strength numerically and analytically, this concepts has generated the required results making the model imperative to predict compressive strength at any curing age.
A UNIFIED APPROACH TO SPURIOUS SOLUTIONS INTRODUCED BY TIME DISCRETISATION.

The asymptotic states of numerical methods for initial value problems are examined. In particular, spurious steady solutions, solutions with period 2 in the timestep, and spurious invariant curves are studied. A numerical method is considered as a dynamical system parameterised by the timestep h. It is shown that the three kinds of spurious solutions can bifurcate from genuine steady solutions of the numerical method (which are inherited from the differential equation) as h is varied. Conditions under which these bifurcations occur are derived for Runge-Kutta schemes, linear multistep methods, and a class of predictor-corrector methods in a PE(CE) M implementation. The results are used to provide a unifying framework to various scattered results on spurious solutions which already exist in the literature. Furthermore, the implications for choice of numerical scheme are studied. In numerical simulation it is desirable to minimise the effect of spurious solutions. Classes of methods with desirable dynamical properties are described and evaluated.
Leakage Power Reduction and Power Delay Product (PDP) Improvement using Dual Stack Method

— Leakage power reduction of CMOS technology is nowadays a vast challenge. International Technology Roadmap for Semiconductors (ITRS) [1] information that Leakage power consumption can come to dominate total chip power consumption as the technology feature size get smaller. Leakage is a serious problem particularly for CMOS circuits in nanoscale technology. This paper presents the designing and analysis on inverter, chain of four inverters and 4:1 multiplexer circuits with dissimilar types of power gated parameter using low power VLSI design techniques and exhibit the evaluation between different nanometer technologies. In this paper the performance of the conventional inverter circuit, chain of four inverter circuits and 4:1 multiplexer circuit is compared with the performance of the different types of power gated parameters. In the dissimilar types of power gated parameters are good high degree of power reduction is reported. Another factor such as delay and power delay product (PDP) is also been calculated for all the circuits. All the circuits are simulated in HSPICE and delay is calculated using Cosmo scope.
PALEO, 23 | 2012

The ways in which Neanderthals exploited the landscape and raw material sources constitute a major aspect of the study of Middle Palaeolithic settlement systems. The Aquitaine Basin in the south-west of France, and more specifically the Charente, has been the object of numerous studies exploring open-air sites within the mineral environment (e.g. Park & Féblot-Augustins 2010). The recently discovered Mousterian workshop of Chêne Vert at Dirac, located on a flint outcrop and excavated in a rescue context, presents a rare opportunity for studying Neanderthal procurement strategies directly associated with a readily available raw material. The main excavation results presented in this article, through geoarchaeology, taphonomy, petroarchaeology and lithic techno-economy, shed light on site formation processes affecting the archaeological level, the assemblage’s degree of integrity and technical behaviour and adaptations to the specific features of flint from Dirac, prior to the transition between MIS 4 and 3.
Development of In-House Head Computed Tomography Dose Index Phantoms Based on Polyester-Resin Materials

Article type: Original Paper Introduction: Computed tomography dose index (CTDI) phantoms are used to optimize CT examinations in terms of image quality and the received dose. In this study, we aimed to develop cost-effective head CTDI phantoms from polyester-resin (PESR) materials as alternative phantoms. Material and Methods: The PESR was mixed with methyl ethyl ketone peroxide (MEKP) as a catalyst. The ratios of MEKP to PESR were 1:150, 1:200, 1:250, and 1:300, respectively. The phantom dimensions were designed similar to the standard CTDI phantom, i.e., length of 15 cm and diameter of 16 cm with five holes (diameter, 1.31 cm). The CTDI measurements using the PESR-MEKP phantoms were compared with the CTDI measurements using the standard polymethyl methacrylate (PMMA) phantom. Results: The results showed that the CTDI values of the PESR-MEKP phantoms were slightly higher (up to 6%) than the standard PMMA phantom. It was found that the CTDI measured by the PESR-MEKP phantom with a ratio of 1:300 had the least significant difference from the standard PMMA phantom; also, at this ratio, the phantom was the most homogeneous. Conclusion: The head CTDI phantoms based on PESR-MEKP materials were developed and evaluated in this study. It was found that the PR-MEKP phantom with a MEKP-to-PESR ratio of 1:300 was insignificantly different from the standard PMMA phantom. Also, the phantom was constructed easily at a more reasonable cost, compared to the standard phantom. Article history: Received: Nov 14, 2019 Accepted: Mar 16, 2020
LETTER TO THE EDITOR USE OF FLUORESCEIN-PHALLOIDIN AND DAPI AS A COUNTERSTAIN FOR IMMUNOFLUORESCENCE MICROSCOPIC STUDIES WITH SEMITHIN FROZEN SECTIONS

Although the immunofluorescence method is a versatile procedure, it is sometimes difficult to specify the positive sites against the dark background. In the immunoperoxidase method, counterstaining of the nuclei with methylgreen or hematoxylin greatly helps the identification of cells and tissues. When semithin frozen sections are employed in immunofluorescence studies, a discrete staining pattern is obtained against the low background (5, 7, 8). Confocal imaging also provides clear fluorescence images with very low background (11). However, identification of the
Effort–Reward Imbalance, Overcommitment, Perceived Control and Health Behaviours in Central and Eastern Europe

AIMS: Health behaviours – alcohol drinking, smoking, poor diet and physical inactivity – are influenced by various psychosocial factors. Despite evidence linking work stress and personality constructs independently to health behaviours, only limited literature is available on the relationship between work stress, personality and health behaviours. The aims of the thesis are: (1) to examine the potential role of overcommitment (OC) personality in the relationship between work stress defined by the Effort–Reward Imbalance (ERI) model and health behaviours; (2) to investigate the potential role of perceived control (PC) in the relationship between ERI, OC and health behaviours. METHODS: This project used data from the HAPIEE (Health, Alcohol and Psychosocial factors In Eastern Europe) study, which randomly selected people aged 45 to 69 years from population registers in Russia, Poland and the Czech Republic. A two–wave cohort study for drinking and smoking outcomes (n= 7,513) and a cross–sectional study for dietary outcomes (n= 11,012) were analysed by logistic regression and structural equation modelling. RESULTS: In terms of the potential role of OC in the relationship between ERI and health behaviours, OC and ERI may have bi–directional relationship; the effect of OC on ERI was stronger than the other direction in the middle–aged and older populations. Thus, antecedent role of OC in the relation between ERI and health behaviours was statistically significant, but mediator role of OC was not. With regards to the potential role of PC in the relationship between OC, ERI and health behaviours, both ERI and PC partially mediated the effects of OC on health behaviours; ERI and PC may have bi–directional relationship. CONCLUSION: This thesis will contribute to deeper understanding of intersecting pathways by which work stress (ERI) and personality constructs (OC and PC) jointly influence health behaviours, thereby providing insight into research, practice and policy
Localization of Bone Disease with Radiostrontium1

Radioisotopes of calcium and strontium, by virtue of their deposition in bone, are of diagnostic value in the detection of bone disease. At this institute, a rigorous measurement program has been developed to aid in the diagnosis of secondary bone malignancy, particularly when radio graphic findings are equivocal or negative. Serial counts are made over selected sites five times over a 96-hour period and from these measurements the clearance of the radioisotope from a given site is established. This information is essential to formulate a diagnosis. The technique can be employed successfully in a radioisotope department when only manually operated equipment is available and the method gives a higher degree of accuracy than manual techniques previously described (1,2). Although the investigation takes several days to complete, the patient does not have long periods of examination at any one time. This procedure is in contrast to that of automatic bone scanning, which involves longer individual measurement periods, although the overall time of the investigation is less.