Miracle-dz/UniFAR-FTUs huggingface dataset:
Mammary Epithelial-specific Deletion of the Focal Adhesion Kinase Gene Leads to Severe Lobulo-Alveolar Hypoplasia and Secretory Immaturity of the Murine Mammary Gland*

Integrin-mediated cell adhesion and signaling is required for mammary gland development and functions. As a major mediator of integrin signaling, focal adhesion kinase (FAK) has been implicated to play a role in the survival, proliferation, and differentiation of mammary epithelial cells in previously studies in vitro. To assess the role of FAK in vivo, we created mice in which FAK is selectively deleted in mammary epithelial cells. The mammary gland FAK conditional knock-out (MFCKO) mice are viable, fertile, and macroscopically indistinguishable from the control littermates. In virgin MFCKO mice, mammary ductal elongation is retarded at 5 weeks of age but reaches the full extent by 8 weeks of age compared with the control mice. However, the MFCKO females are unable to nurse their pups due to severe lobulo-alveolar hypoplasia and secretory immaturity during pregnancy and lactation. Analysis of the mammary epithelial cells in MFCKO mice showed reduced Erk phosphorylation, expression of cyclin D1, and a corresponding decrease in proliferative capability compared with the littermate controls. In addition, phosphorylation of STAT5 and expression of whey acidic protein are significantly reduced in the mammary glands of MFCKO mice, suggesting defective secretory maturation in these mice. Therefore, the combination of the severe lobulo-alveolar hypoplasia and defective secretory differentiation is responsible for the inability of the MFCKO females to nurse their pups. Together, these results provide strong support for a role of FAK in the mammary gland development and function in vivo.
Meta-analysis of stapled hemorrhoidopexy vs LigaSure hemorrhoidectomy.

AIM To compare outcome of stapled hemorrhoidopexy (SH) vs LigaSure hemorrhoidectomy (LH) by a meta-analysis of available randomized controlled trials (RCTs). METHODS Databases, including PubMed, EMBASE, the Cochrane Library, and the Science Citation Index updated to December 2012, were searched. The main outcomes measured were operating time, early postoperative pain, postoperative urinary retention and bleeding, wound problems, gas or fecal incontinence, anal stenosis, length of hospital stay, residual skin tags, prolapse, and recurrence. The meta-analysis was performed using the free software Review Manager. Differences observed between the two groups were expressed as the odds ratio (OR) with 95%CI. A fixed-effects model was used to pool data when statistical heterogeneity was not present. If statistical heterogeneity was present (P < 0.05), a random-effects model was used. RESULTS The initial search identified 10 publications. After screening, five RCTs published as full articles were included in this meta-analysis. Among the five studies, all described a comparison of the patient baseline characteristics and showed that there was no statistically significant difference between the two groups. Although most of the analyzed outcomes were similar between the two operative techniques, the operating time for SH was significantly longer than for LH (P < 0.00001; OR= -6.39, 95%CI: -7.68 - -5.10). The incidence of residual skin tags and prolapse was significantly lower in the LH group than in the SH group [2/111 (1.8%) vs 16/105 (15.2%); P = 0.0004; OR= 0.17, 95%CI: 0.06-0.45). The incidence of recurrence after the procedures was significantly lower in the LH group than in the SH group [2/173 (1.2%) vs 13/174 (7.5%); P = 0.003; OR= 0.21, 95%CI: 0.07-0.59]. CONCLUSION Both SH and LH are probably equally valuable techniques in modern hemorrhoid surgery. However, LigaSure might have slightly favorable immediate postoperative results and technical advantages.
Autonomic Cardiac Activity in Patients with Smoking and Alcohol Addiction by Heart Rate Variability Analysis.

PURPOSE Smoking and alcohol addictions are common and worldwide. In the present study, we aimed to investigate the effects of these addictions on cardiac rhythm using heart rate variability (HRV) analysis. METHODS Addicts (n=42 men: 22 cigarette; 20 cigarette and alcohol) and age-matched controls (n=34 men) were included in the study. All patients fulfill the criteria for dependence according to DSM-IV-TR. Electrocardiography (ECG) recordings were obtained for a total of 30 minutes. Fagerstrom Nicotine Addiction Test (FNAT) and CAGE questionnaire (Cut down, Annoy, Guilt, Eye opener) was applied to all patients. RESULTS Almost all HRV parameters were significantly decreased in cigarette and cigarette and alcohol addicts compared with controls (p.
Coagulation Factor VII Activity, Arg/Gln353 Polymorphism and Features of Insulin Resistance in First-Degree-Relatives of South Asian Patients with Stroke

Summary The aim of the study was to determine associations of factor VII:C levels in 140 South Asian stroke subjects and 143 first-degree relatives versus age-sex matched 146 control subjects without a personal or a family history of stroke subjects living in UK. There were no significant differences in Factor VII:C levels or FVII Msp I gene polymorphism (Arg-Gln 353) R353Q genotype frequency between the groups. R353Q genotype determined Factor VII:C levels in all the three groups. Factor VII:C levels correlated with triglycerides (patients, r = 0.23; relatives r = 27; control subjects, r = 0.24) and plasminogen activator inhibitor activity (patients, r = 0.30; relatives r = 0.22; control subjects r = 0.20) in all the three groups, but with insulin only in patients (p = 0.19). Circulating levels of Factor VII:C are determined by R353Q genotype and cluster with other risk factors associated with insulin resistance in South Asian ischaemic stroke patients, first-degree relatives and control subjects but are not related to stroke or a family history of stroke.
Visual navigation using omnidirectional view sequence

View-based or appearance-based approaches have been attracting the interests of computer vision research. We have already proposed a visual view-based navigation method using a model of the route called the "view sequence", which contains a sequence of front views along a route memorized in the teaching run. In this paper, we apply an omnidirectional vision sensor to our view-based navigation and propose an extended model of a route called "omni-view sequence". The omnidirectional vision sensor is a desirable sensor for real-time view-based recognition of a mobile robot because all the information around the robot can be acquired simultaneously. The use of omnidirectional images contribute to a better navigation method in three ways: (1) it enables the robot to come back along the route using the same view sequence, (2) it improves the accuracy of the navigation and (3) it improves the robustness of the matching. These improved points are shown through experiments, and indoor navigation, including getting on and off an elevator, is demonstrated.
A Causal and Real-Time Capable Power Management Algorithm for Off-Highway Hybrid Propulsion Systems

Hybrid propulsion systems allow for a reduction of fuel consumption and pollutant emissions of future off-highway applications. A challenging aspect of a hybridization is the larger number of system components that further increases both the complexity and the diversification of such systems. Hence, beside a standardization on the hardware side for off-highway systems, a high flexibility and modularity of the control schemes is required to employ them in as many different applications as possible. In this paper, a causal optimization-based power management algorithm is introduced to control the power split between engine and electric machine in a hybrid powertrain. The algorithm optimizes the power split to achieve the maximum power supply efficiency and, thereby, considers the energy cost for maintaining the battery charge. Furthermore, the power management provides an optional function to control the battery state of charge in such a way that a target value is attained. In a simulation case study, the potential and the benefits of the proposed power management for the hybrid powertrain—aiming at a reduction of the fuel consumption of a DMU (diesel multiple unit train) operated on a representative track—will be shown.
Modeling Thermophysical Properties of Food Under High Pressure

A set of well-known generic models to predict the thermophysical properties of food from its composition at atmospheric conditions was adapted to work at any pressure. The suitability of the models was assessed using data from the literature for four different food products, namely tomato paste, potato, pork, and cod. When the composition of the product considered was not known, an alternative was proposed if some thermal data at atmospheric conditions were available. Since knowledge on the initial freezing point and ice content of food are essential for the correct prediction of its thermal properties, models for obtaining these properties under pressure were also included. Our results showed that good predictions under pressure, accurate enough for most engineering calculations can be made, either from composition data or using known thermal data of the food considered at atmospheric conditions. All the equations and coefficients needed to construct the models are given throughout the text, thus readers can compose their own routines. However, these routines can also be downloaded free at http://www.if. csic.es/programas/ifiform.htm as executable programs running in Windows.
A global atmospheric model of meteoric iron

The first global model of meteoric iron in the atmosphere (WACCM‐Fe) has been developed by combining three components: the Whole Atmosphere Community Climate Model (WACCM), a description of the neutral and ion‐molecule chemistry of iron in the mesosphere and lower thermosphere (MLT), and a treatment of the injection of meteoric constituents into the atmosphere. The iron chemistry treats seven neutral and four ionized iron containing species with 30 neutral and ion‐molecule reactions. The meteoric input function (MIF), which describes the injection of Fe as a function of height, latitude, and day, is precalculated from an astronomical model coupled to a chemical meteoric ablation model (CABMOD). This newly developed WACCM‐Fe model has been evaluated against a number of available ground‐based lidar observations and performs well in simulating the mesospheric atomic Fe layer. The model reproduces the strong positive correlation of temperature and Fe density around the Fe layer peak and the large anticorrelation around 100 km. The diurnal tide has a significant effect in the middle of the layer, and the model also captures well the observed seasonal variations. However, the model overestimates the peak Fe+concentration compared with the limited rocket‐borne mass spectrometer data available, although good agreement on the ion layer underside can be obtained by adjusting the rate coefficients for dissociative recombination of Fe‐molecular ions with electrons. Sensitivity experiments with the same chemistry in a 1‐D model are used to highlight significant remaining uncertainties in reaction rate coefficients, and to explore the dependence of the total Fe abundance on the MIF and rate of vertical transport.
Saliency parsing for automated directory assistance

In a statistical language model based automated directory assistance system, extracting the salient information from the recognition output can significantly increase the accuracy of the backend listing database search. In this paper, we describe a Hidden Markov model (HMM) based saliency parser that was developed to accurately and efficiently identify salient words from the recognition output by modeling both the syntactic structure as well as the lexical distribution. The parser can be trained using a relatively small data set with coarse syntactic class labels, without the need for detailed syntactic knowledge or a treebank-like corpus. Experimental results on a research corpus of directory assistance utterances betoken the parser’s importance within the automated system. The results demonstrate that the proposed saliency parser can significantly improve the overall automation rate without increasing the error rate.
Pilot scale processing of detergent-based aqueous two-phase systems.

Detergent based aqueous two-phase systems have several specific properties, e.g., extreme small density differences between the two liquid phases (0.003-0.005 g/cm(3)), low interfacial tensions (5-10 microN/m) and complex rheological behavior of the product containing detergent-rich phase, which make processing difficult. We describe the successful separation of these aqueous two-phase systems in the pilot scale (1-20 kg) in the presence and absence of microbial cells, either by settling under gravity or in centrifugal separators. The performance of self-desludging liquid-liquid separators and of a nozzle separator was analyzed in detail to judge large scale application. With a feed rate of 16 L/h, stable operation was possible in the desludging machine. Up to 56 L/h could be processed with very close control of the hydrodynamic balance. In a small nozzle separator, feed rates of 90 L/h could be realized, but the purity of the separated phases and the yield of the top phase was slightly lower than in the liquid-liquid separator. The presence of surface-active components in the feed may alter the separation characteristics of the phase systems significantly. (c) 1997 John Wiley & Sons, Inc. Biotechnol Bioeng 55: 339-347, 1997.
A BRIEF HISTORY OF THE DERMATOLOGIC MOULAGE IN EUROPE. PART III: PROSPERITY AND DECLINE

The first dermatovenereologic moulageurs—Franz Heinrich Martens (1778-1805) in Jena, Joseph Towne (1806-1879) in London, and Anton Elfinger (18211864) in Vienna—formed a generation of modeling pioneers who remained without successors. The art did not spread beyond their respective regions to wider use in Europe. In the second half of the 19th century Paris and Vienna became centers for the institutionalization of the young field of dermatovenereology and at the same time also developed important moulagitig traditions. The First International Congress of Dermatology and Syphilology, which took place August 5 to 10, 1889, at the Parisian Hopital Saint Louis, had a catalytic effect on moulaging. It caused the art to be introduced to an international audience of dermatologic specialists as a highly effective teaching method.
Identification of cis-acting sequences responsible for phorbol ester induction of human serum amyloid A gene expression via a nuclear factor kappaB-like transcription factor

We have analyzed the 5'-flanking region of one of the genes coding for the human acute-phase protein, serum amyloid A (SAA). We found that SAA mRNA could be increased fivefold in transfected cells by treatment with phorbol 12-myristate 13-acetate (PMA). To analyze this observation further, we placed a 265-base-pair 5' SAA fragment upstream of the reporter chloramphenicol acetyltransferase (CAT) gene and transfected this construct into HeLa cells. PMA treatment of these transient transfectants resulted in increased CAT expression. Nuclear proteins from PMA-treated HeLa cells bound to this DNA fragment, and methylation interference analysis showed that the binding was specific to the sequence GGGACTTTCC (between -82 and -91), a sequence previously described by R. Sen and D. Baltimore (Cell 46:705-716, 1986) as the binding site for the nuclear factor NF kappa B. In a cotransfection competition experiment, we could abolish PMA-induced CAT activity by using cloned human immunodeficiency virus long-terminal-repeat DNA containing the NF kappa B-binding sequence. The same long-terminal-repeat DNA containing mutant NF kappa B-binding sequences (G. Nabel and D. Baltimore, Nature [London] 326:711-713, 1987) did not affect CAT expression, which suggested that binding by an NF kappa B-like factor is required for increased SAA transcription.
Examination of the Content Specificity of Posttraumatic Cognitions in Combat Veterans With Posttraumatic Stress Disorder

Objective: Cognitive theories have proposed the idea of content specificity, which holds that emotional disorders are associated with unique sets of negative cognitions. The existent research exploring the content specificity related to posttraumatic stress disorder (PTSD) and depression is sparse, and research is especially needed in veteran samples. The purpose of this study was to examine the associations of PTSD symptom clusters and comorbid depressive symptoms with posttraumatic cognitions. Method: This study was cross-sectional in design, and the sample consisted of data from 150 male combat veterans with PTSD drawn from the baseline assessments of a large clinical trial. Analyses involved a series of separate and simultaneous linear regressions to examine the unique associations of comorbid depressive symptoms and PTSD symptom clusters with posttraumatic cognitions, as well as post hoc analyses to examine the mediational role of comorbid depressive symptoms. Results: Findings demonstrated that posttraumatic negative cognitions about the self and self-blame were most strongly associated with comorbid depressive symptoms and the depression-related PTSD numbing cluster. Comorbid depressive symptoms also partially mediated nearly all the relationships between posttraumatic cognitions and PTSD symptom clusters. Conclusions: The findings of this study suggest that posttraumatic cognitions about the self and self-blame are not specific to PTSD but rather are more strongly related to symptoms of depression and negative affect. The results also suggest a potential pathway from posttraumatic cognitions to PTSD through the partially mediating influence of comorbid depression, and highlight the need to assess and treat comorbid depression in veterans with PTSD.
Adaptive Fusion of Inertial Navigation System and Tracking Radar Data

81 AIJ Electrical & Electronics Engineering, Vol 48, No. 2, Fall 2016 Please cite this article using: Fathi, M. , Ghahramani, N. , Ashtiani, M. A. S. , Mohammadi, A. , and Fallah, M. , 2016. “Adaptive Fusion of Inertial Navigation System and Tracking Radar Data”. Amirkabir International Journal of Electrical and Electronics Engineering, 48(2), pp. 81–91. DOI: 10.22060/eej.2016. 818 URL: http://eej.aut. ac.ir/article_818. html *Corresponding Author, Email: mahd_fathi@mut.ac.ir Adaptive Fusion of Inertial Navigation System and Tracking Radar Data
A PAC-Bayesian Approach to Structure Learning

Structure learning is an important sub-domain of machine learning. Its goal is a high level understanding of the data. For example, given an image as a collection of pixels, the goal is to identify the objects present in the image, such as people, trees, birds, to infer their actions (e.g., standing, flying) and interactions (e.g. a man is feeding a bird). Structure learning has multiple applications in a variety of domains, including the analysis of cellular processes in biology, computer vision, and natural language processing, to name only a few. In the recent couple of decades enormous progress has been made in data analysis methods that are not based on explicit structure, such as Support Vector Machines (SVMs) or other kernel-based methods. Nevertheless, the importance of learning explicit structures remains crucial. There are multiple benefits to structure-based learning as opposed to methods, where structure is present implicitly, e.g. in the form of a kernel. The primary reason is that it is easier for us as humans to manipulate objects like cars and people rather than raw pixels or kernel matrices. For example, a natural query for a human would be: “find the photos of me picking mushrooms last summer”. Thus we need a learning algorithm to go all the way up from pixels to persons, mushrooms, trees, etc., and also actions like picking, standing, and so on. Another important reason to learn structure in data is “to understand the world around us” for example, to understand biological processes or even how our own brain works. It also becomes easier to control or influence different processes once we learn their structure and extract simple rules governing their dynamics. Often, the amount of supervision available for a learning algorithm in a
Measurement of the diffractive longitudinal structure function

First measurements are presented of the diffractive cross section σep→eXY at centre-of-mass energies √ s of 225 and 252 GeV, together with a precise new measurement at √ s of 319 GeV, using data taken with the H1 detector in the years 2006 and 2007. Together with previous H1 data at √ s of 301 GeV, the measurements are used to extract the diffractive longitudinal structure function F L in the range of photon virtualities 4.0 ≤Q2 ≤ 44.0 GeV2 and fractional proton longitudinal momentum loss 5× 10−4 ≤ xP ≤ a e-mail: daum@mail.desy. de bAlso at Physics Department, National Technical University, Zografou Campus, 15773 Athens, Greece cAlso at Rechenzentrum, Universitat Wuppertal, Wuppertal, Germany dAlso at University of P.J. Safarik, Kosice, Slovak Republic eAlso at CERN, Geneva, Switzerland fAlso at Max-Planck-Institut fur Physik, Munchen, Germany gAlso at Comenius University, Bratislava, Slovak Republic hAlso at Faculty of Physics, University of Bucharest, Bucharest, Romania iAlso at Ulaanbaatar University, Ulaanbaatar, Mongolia jSupported by the Initiative and Networking Fund of the Helmholtz Association (HGF) under the contract VH-NG-401 kAbsent on leave from NIPNE-HH, Bucharest, Romania lOn leave of absence at CERN, Geneva, Switzerland mSupported by the Bundesministerium fur Bildung und Forschung, FRG, under contract numbers 05H09GUF, 05H09VHC, 05H09VHF, 05H16PEA nSupported by the UK Science and Technology Facilities Council, and formerly by the UK Particle Physics and Astronomy Research Council 3× 10−3. The measured F L is compared with leading twist predictions based on diffractive parton densities extracted in NLO QCD fits to previous measurements of diffractive Deep-Inelastic Scattering and with a model which additionally includes a higher twist contribution derived from a colour dipole approach. The ratio of the diffractive cross section induced by longitudinally polarised photons to that for transversely polarised photons is extracted and compared with the analogous quantity for inclusive Deep-Inelastic Scattering. oSupported by FNRS-FWO-Vlaanderen, IISN-IIKW and IWT and by Interuniversity Attraction Poles Programme, Belgian Science Policy pPartially Supported by Polish Ministry of Science and Higher Education, grant DPN/N168/DESY/2009 qSupported by the Deutsche Forschungsgemeinschaft rSupported by VEGA SR grant No. 2/7062/27 sSupported by the Swedish Natural Science Research Council tSupported by the Ministry of Education of the Czech Republic under the projects LC527, INGO-LA09042 and MSM0021620859 uSupported by the Swiss National Science Foundation vSupported by CONACYT, Mexico, grant 48778-F wRussian Foundation for Basic Research (RFBR), grant no 1329.2008. 2 xThis project is co-funded by the European Social Fund (75%) and National Resources (25%)–(EPEAEK II)–PYTHAGORAS II ySupported by the Romanian National Authority for Scientific Research under the contract PN 09370101 zPartially Supported by Ministry of Science of Montenegro, No. 051/3-3352