Miracle-dz/UniFAR-FTUs huggingface dataset:
Appendix to “ Periodograms for movement ecologists : a non-parametric method to uncover periodic patterns of space use in animal tracking data ”

non-parametric method to uncover periodic patterns of space use in animal tracking data” Guillaume Péron, Chris H. Fleming, Rogerio C. de Paula, and Justin M. Calabrese Conservation Ecology Center, Smithsonian Conservation Biology Institute, National Zoological Park, 1500 Remount Rd., Front Royal, VA 22630 Department of Biology, University of Maryland College Park, College Park, Maryland 20742 National Research Center for Carnivore Conservation (CENAP/ICMBio), Atibaia, Sao Paulo, Brazil
A positron emission tomography study of essential tremor: Evidence for overactivity of cerebellar connections

The origin of essential tremor is unknown. Animal models have suggested that the inferior olivary nucleus may act as a tremor generator. We used positron emission tomography to study changes in regional cerebral blood flow associated with involuntary postural tremor and passive wrist oscillation in patients with essential tremor. Activation due to voluntary wrist oscillation and arm extension without tremor was studied in normal control subjects. The essential tremor group had bilaterally increased cerebellar blood flow at rest (without tremor) compared with the control group. Involuntary postural tremor was associated with further bilateral cerebellar activation, and also contralateral striatal, thalamic, and sensorimotor cortex activation. Voluntary wrist oscillation, maintained arm extension without tremor, and passive wrist oscillation were all associated with significant ipsilateral rather than bilateral cerebellar activation. We conclude that essential tremor is associated with increased bilateral cerebellar activity both at rest and during tremor.
Enhanced insulin‐receptor tyrosine kinase activity associated with chromosomal translocation (1;19) in a pre‐B‐cell leukemia line

The gene for the insulin receptor has been assigned to chromosome 19 near the breakpoint of the translocation t( 1; 19) which occurs in 25% of pre‐B‐cell leukemias. Insulin receptors in a pre‐B‐cell leukemia cell line (ACV) with t(1;19) were found to have 2‐fold higher affinity for insulin, 5‐fold higher basal and insulin‐stimulated p sub‐unit autophosphorylation, and 2‐fold higher basal and 4‐fold higher insulin‐stimulated β sub‐unit kinase activity on the synthetic peptide poly(Glu,Tyr), compared to receptors in a B‐cell line (ADD) with normal karyotype from the same patient. ACV cells had a novel 13‐kb receptor mRNA species and expressed a DNA polymorphism localized to the tyrosine kinase domain of the receptor gene. These findings suggest that t(l;19) in the ACV cell may result in rearrangement of the insulin receptor gene and translation of a receptor with enhanced tyrosine kinase activity.
Lung imaging

Imaging of the lung is a mainstay of respiratory medicine. It provides local information about morphology and function of the lung parenchyma that is unchallenged by other noninvasive techniques. During the 2014 European Respiratory Society International Congress in Munich, Germany, a Clinical Year in Review session was held focusing on the latest developments in pulmonary imaging. This review summarises some of the main findings of peer-reviewed articles that were published in the 12-month period prior to the 2014 International Congress. Imaging provides noninvasive access to thoracic morphology and function; this review summarises recent highlights http://ow.ly/KbVtd
Chapter 3 Constructive generation methods for dungeons and levels

This chapter addresses a specific type of game content, the dungeon, and a number of commonly used methods for generating such content. These methods are all “constructive”, meaning that they run in fixed (usually short) time, and do not evaluate their output in order to re-generate it. Most of these methods are also relatively simple to implement. And while dungeons, or dungeon-like environments, occur in a very large number of games, these methods can often be made to work for other types of content as well. We finish the chapter by talking about some constructive generation methods for Super Mario Bros. levels. 3.1 Dungeons and levels A dungeon, in the real world, is a cold, dark and dreadful place where prisoners are kept. A dungeon, in a computer game, is a labyrinthine environment where adventurers enter at one point, collect treasures, evade or slay monsters, rescue noble people, fall into traps and ultimately exit at another point. This conception of dungeons probably originated with the role-playing board game Dungeons and Dragons, and has been a key feature of almost every computer role-playing game (RPG), including genre-defining games such as the Legend of Zelda series and the Final Fantasy series, and recent megahits such as The Elder Scrolls V: Skyrim. Of particular note is the “roguelike” genre of games which, following the original Rogue from 1980, features procedural runtime dungeon generation; the Diablo series is a high-profile series of games in this tradition. Because of this close relationship with such successful games, and also due to the unique control challenges in their design, dungeons are a particularly active and attractive PCG subject. For the purposes of this chapter, we define adventure and RPG dungeon levels as labyrinthic environments, consisting mostly of interrelated challenges, rewards and puzzles, tightly paced in time and space to offer highly structured gameplay progressions [9]. An aspect which sets dungeons apart from other types of levels
Folding of the mitochondrial proton adenosinetriphosphatase proteolipid channel in phospholipid vesicles.

The mitochondrial H+-ATPase proteolipid from Neurospora crassa was incorporated into small unilamellar dimyristoylphosphatidylcholine vesicles and its conformation determined by circular dichroism spectroscopy (CD). While the largely alpha-helical conformation is relatively independent of the method of incorporation into vesicles, i.e., rehydration, detergent dialysis, or detergent dilution, the proteolipid conformation was significantly different in detergent micelles and in organic solvents. Only very slight changes in the CD spectrum were observed upon binding of the H+-ATPase inhibitor dicyclohexylcarbodiimide to the proteolipid in vesicles, thus suggesting that the inhibitor acts either by blocking the channel or by masking an essential charge group, rather by than causing an overall conformational change in the channel. Additionally, very similar CD spectra were obtained for vesicles with different lipid/protein mole ratios, indicating either that no substantial conformational differences exist between monomer and multimers or that monomers self-associate to form stable complexes during incorporation into vesicles. This study has provided a physical basis for model-building studies of the proteolipid channel structure.
In vitro bactericidal effects of near-ultraviolet light from light-emitting diodes on Helicobacter pylori

Abstract We investigated whether near-ultraviolet light emitted from light-emitting diodes (LEDs) effects Helicobacter pylori viability and whether this new method can potentially apply to eradication therapy. Three H. pylori strains were used for near-ultraviolet (UV) LED irradiation experiments. Viability of isolates exposed to near-UV light was compared with controls by counting colony forming units. A time-dependent bactericidal effect of near-UV light was definitely observed. LED irradiation with near-UV light showed effective bactericidal activity against H. pylori strains. Eradication therapy with LED might provide a new avenue of treatment in patients refractory to eradication due to antibiotic resistance and/or adverse effects of antibiotics.
3D TCAD simulation of single-event-effect in n-channel transistor based on deep sub-micron fully-depleted silicon-on-insulator technology

3D fully-depleted silicon-on-insulator (FDSOI) n-channel transistor model is constructed by the accurate calibration between process information from OKI and Synopsys TCAD tool. Single-event-effect (SEE) simulations are conducted based on the 3D model to evaluate the collected charge from different heavy ion strike locations. The channel is the most SEE sensitive region along channel length direction in terms of the collected charge. The TCAD simulations of the collected charge along channel width direction are constrained by the boundary condition. This paper provides the guide for the SEE hardening improvement of the FDSOI process and device structure.
Receptive Phoneme Sequencing Knowledge of Kindergarten and Elementary School Age Children

A new instrument was devised to investigate receptive phoneme-sequencing knowledge of a group of normally articulating children of kindergarten and elementary school age. Phoneme sequences, in the initial or final position of monosyllabic nonsense syllables that either adhered to or violated the phoneme-sequencing rules of American English, were tested. Older children correctly identified significantly more phoneme sequences than younger children. All children correctly identified significantly more impossible phoneme sequences than possible sequence items. Children did not abstract and internalize the rules for sequencing phonemes on a level comparable with that for adults until the ninth or tenth year of life. Decision-making strategies used by children to identify phoneme sequences were discussed.
Sex, cheating, and disgust: Enhanced source memory for trait information that violates gender stereotypes

The present study examines memory for social-exchange-relevant information. In Experiment 1 male and female faces were shown together with behaviour descriptions of cheating, altruistic, and neutral behaviour. Previous results have led to the hypothesis that people preferentially remember schema-atypical information. Given the common gender stereotype that women are kinder and less egoistic than men, this atypicality account would predict that source memory (that is, memory for the type of context to which a face was associated) should be enhanced for female cheaters in comparison to male cheaters. The results of Experiment 1 confirmed this hypothesis. Experiment 2 reveals that source memory for female faces associated with disgusting behaviours is enhanced in comparison to male faces associated with disgusting behaviours. Thus the atypicality effect generalises beyond social-exchange-relevant information, a result which is inconsistent with the assumption that the findings can be ascribed to a highly specific cheater detection module.
KGRL: An OWL2 RL Reasoning System for Large Scale Knowledge Graph

Currently knowledge graph has been widely applied to various fields. Although the data scale is large, there is still a lot of useful but implicit information in it. Thus, a powerful reasoning system is required to derive these data. However, current reasoning systems cannot accomplish this task very well. On the one hand, stand-alone reasoning systems cannot meet the demand of large data. On the other hand, the reasoning ability of existing distributed reasoning systems is limited because of the lack of expressive inference rules. In this paper, we propose and implement a distributed reasoning system KGRL for knowledge graph based on OWL2 RL. It has a more powerful reasoning ability due to more expressive rules. It also supports optimization for redundant data. Besides, a rule-based algorithm is designed to find the inconsistent data. Experimental results show that KGRL can derive more implicit information efficiently compared to other reasoning systems. Moreover, KGRL is capable of eliminating redundant data, which can reduce the storage of knowledge graph by an average of 42%. Finally, KGRL also performs well for the detection of inconsistencies in knowledge graph.
Longitudinal changes in mobility following single-event multilevel surgery in ambulatory children with cerebral palsy.

OBJECTIVE To examine changes in mobility longitudinally following single-event multilevel surgery in ambulant children with cerebral palsy, focusing on those using assistive devices for functional mobility because they are most at risk of declining gross motor function. PARTICIPANTS A consecutive sample of 156 ambulant children with cerebral palsy (99 males), 96 without devices (Gross Motor Function Classification System (GMFCS) I/II), 60 with devices (GMFCS III) who had single-event multilevel surgery at mean age 11 years 1 month. METHODS GMFCS and Functional Mobility Scale (FMS) ratings were recorded pre-operatively and at 2 and 5 years post-operatively. A proportional odds logistic regression model was used for the GMFCS III group to predict the probability of assistive device requirements post-operatively conditional on baseline FMS. RESULTS Children in GMFCS III showed more change than those in I/II at home and school. Those in GMFCS III using crutches pre-operatively at home and school were more likely to continue using them at 5 years, whereas those using walkers were more likely to change to crutches or wheelchairs. Wheelchairs were most commonly used in the community before and after single-event multilevel surgery. CONCLUSION Mobility was generally stable or improved at 5 years after single-event multilevel surgery; however, a small number of children used more assistance to facilitate mobility.
Diffusion MRI: mitigation of magnetic field inhomogeneities

Abstract The article reports on certain artifacts that emerge during the in vitro diffusion-weighted imaging of physical samples. In this context, the authors analyze the influence of magnetic field inhomogeneity, temperature, or eddy currents and consider artifact mitigation procedures. A technique reducing the examined spurious effects was designed, experimentally verified, and denominated as the three measurement method. The technique proved to be useful mainly for the evaluation of a DWI image measured with a diffusion gradient in the z axis, where the relative measurement error decreased to 3.38 % (during measurement using two images, the relative error was greater than 19 %). For small errors within the measurement of diffusion constants of a deionized water sample (< 5 %) it was necessary to select a b-factor value larger than 200·106 s.m-2. Temperature stabilization with accuracy better than 0.1 °C during the entire measuring process is a necessary prerequisite for the measurement of biological or material samples with relative accuracy lower than 1 %.
Anaplastic large cell (CD30/Ki‐1+) lymphoma in HIV+ patients: clinical and pathological findings in a group of ten patients

We compared the clinical and pathological features of 10 HIV+ CD30+ anaplastic large cell lymphoma (ALCL) patients with 28 HIV+ CD30+ non‐Hodgkin's lymphoma (NHL) patients. The incidence of ALCL among 38 HIV+ systemic NHL patients was 26%. Clinical features were similar in all the HIV‐related NHL cases, but ALCL patients seemed to differ from HIV+ CD30− systemic NHL only in the greater frequency of lung tumours (40% v 21%) without concomitant mediastinal mass, bone marrow (75% v 18%) and gastroenteric involvement (40% v 25%). Among the HIV+ ALCL patients, histologic subtypes did not differ in frequency from ALCL in the general population. The B phenotype was predominant (50%) as in other HIV‐related NHL. EBV genoma, studied in all HIV+ ALCL patients, was present in 3/10 by in situ hybridization (ISH) and in 5/10 cases using PCR. The clinical course of lymphomas was similar in CD30 positive and negative NHL patients. Overall survival also was short in our series, particularly in HIV+ ALCL (84 v 188 d), probably because of profound immunodepression of the ALCL patients.
Properties of Human IgG1s Engineered for Enhanced Binding to the Neonatal Fc Receptor (FcRn)*

We describe here the functional implications of an increase in IgG binding to the neonatal Fc receptor. We have defined in a systematic fashion the relationship between enhanced FcRn binding of a humanized anti-respiratory sincytial virus (RSV) monoclonal antibody (MEDI-524) and the corresponding biological consequences in cynomolgus monkeys. The triple mutation M252Y/S254T/T256E (YTE) was introduced into the Fc portion of MEDI-524. Whereas these substitutions did not affect the ability of MEDI-524 to bind to its cognate antigen and inhibit RSV replication, they resulted in a 10-fold increase in its binding to both cynomolgus monkey and human FcRn at pH 6.0. MEDI-524-YTE was efficiently released from FcRn at pH 7.4 in both cases. We show that MEDI-524-YTE consistently exhibited a nearly 4-fold increase in serum half-life in cynomolgus monkeys when compared with MEDI-524. This constituted the largest half-life improvement described to date for an IgG in a primate. For the first time, we demonstrate that these sustained serum levels resulted in an up to 4-fold increase in lung bioavailability. Importantly, we also establish that our non-human primate model is relevant to human. Finally, we report that the YTE triple substitution provided a means to modulate the antibody-dependent cell-mediated cytotoxicity (ADCC) activity of a humanized IgG1 directed against the human integrin αvβ3. Therefore, the YTE substitutions allow the simultaneous modulation of serum half-life, tissue distribution and activity of a given human IgG1.
Single derivatization method for routine analysis of bacterial whole-cell fatty acid methyl esters, including hydroxy acids

Analysis of fatty acid methyl esters prepared from whole-cell bacteria by sodium hydroxide hydrolysis and boron trichloride-catalyzed methylation showed degradation of hydroxy acid peaks after several injections on a fused silica capillary column. A simple base wash of the extracts before injection prevented the tailing of the hydroxy acid peaks even after extended use. This eliminates the need to form trifluoroacetic anhydride derivatives of the hydroxy acids.
Potential energy analysis and limit cycle control for dynamics stability of in-wheel driving electric vehicle

Compared with the conventional vehicle and the signal motor driving electric vehicle, the in-wheel driving electric vehicle will be a tendency of development because of its unique characters of chassis structure and vehicle manipulation. Based on the nonlinear dynamic model of the four-wheel independent driving electric vehicle, the potential energy analysis for its dynamics stability is given, and the corresponding methods of limit cycle control and direct yaw-moment control are used to improve the handling stability of this vehicle. The dynamics model of this vehicle and the dynamics control model are constructed on MATLAB/Simulink software. Performance of this control method for this vehicle dynamics stability is evaluated.
Investigating the impact of customer orientation on innovativeness: evidence from born-global firms in Turkey

Abstract Our study develops and tests a research model that investigates the impact of born-globals’ customer orientation on innovativeness through the mediating roles of technological capability, relationship quality, and relationship information process. Data obtained from 197 small and medium-sized born-global firms in Turkey were used to gauge these relationships through structural equation modelling. The results suggest that born-globals’ customer orientation influences innovativeness indirectly through the mediating role of technological capability. Simply put, technological capability acts as a full mediator between customer orientation and innovativeness. Contrary to our predictions, relationship quality and relationship information process do not significantly influence innovativeness. Therefore, the empirical data do not support the mediating roles of relationship quality and relationship information process. In short, our study contributes to current knowledge by examining the factors that influence the innovativeness of born-globals using data obtained from born-globals in Turkey, which is a newly industrialised country.
Symbol-based physical-layer network coding for two-way relay channel

A symbol-based physical layer network coding (PNC) scheme is proposed for the two-way relay channel where the relay node is equipped with multiple antennas. Unlike the traditional binary PNC that focuses mainly on BPSK modulation, the proposed symbol-based PNC is tailored for the general MPSK modulation. In particular, the product of the two modulated signals is considered as a network-coded symbol, which exploit the characteristic of MPSK modulation to compact the solution space of the intended network-coded symbol. Based on the autocorrelation of the received signal at the relay node, a novel PNC-oriented detection scheme is developed to estimate the network-coded symbol for broadcasting. The proposed scheme achieves receive diversity advantage with linear complexity at the relay node. In addition, the proposed scheme can effectively handle information exchanging with asymmetric data rates between the two sources. Simulation results show that the proposed scheme outperforms other linear-MIMO detection based counterparts in terms of diversity order, and it also outperforms the existing decode-and-forward (DF) and amplify-and-forward (AF) approaches when dealing with the asymmetric information exchanging.
Association of complement receptor type-1 (CD35) gene polymorphism with P. falciparum malarial infection in Vindhyan

Malaria is a chronic disease having large prevalence in tropical and subtropical countries. CD35 protein density on RBCs determines susceptibility to P. falciparum infection. In our population, complement receptor Type-1 (CD35) gene polymorphism determine the density of CD35 protein on RBCs. As we know, CD35 protein is an adhesion protein for P. falciparum and high density confer chances to infection. Polymorphism of CR1 (CD35) gene, SNP Intron 27 (T520C) in our population reveals three genotypes HH, HL and LL. Genotype HL (P=0.0298*) frequent distributed in population and showing association between case and control. In our population LL genotype have protective effect for P. falciparum infection whereas HH, and HL genotype confer high density of CD35 protein on RBCs surface. The frequency of H allele (in case=65.47%, control=55.38%) is high in comparison to L alleles (in case =34.52%, control = 44.61%). Frequency of H and L allele (P= 0.0241*) significantly associated but not carriage rate (P=0.2127) between case and control population. Elevated TNF-α level in blood serum reveals quantity of infection level and having strong association (P<0.0001 ***) with P. falciparum malarial infection.
Opportunistic Spectrum Access with Dynamic Users: Directional Graphical Game and Stochastic Learning

This paper investigates the channel selection problem with dynamic users and the asymmetric interference relation in distributed opportunistic spectrum access systems. Since users transmitting data are based on their traffic demands, they dynamically compete for the channel occupation. Moreover, the heterogeneous interference range leads to asymmetric interference relation. The dynamic users and asymmetric interference relation bring about new challenges such as dynamic random systems and poor fairness. In this article, we will focus on maximizing the tradeoff between the achievable utility and access cost of each user, formulate the channel selection problem as a directional graphical game and prove it as an exact potential game presenting at least one pure Nash equilibrium point. We show that the best NE point maximizes both the personal and system utility, and employ the stochastic learning approach algorithm for achieving the best NE point. Simulation results show that the algorithm converges, presents near-optimal performance and good fairness, and the directional graphical model improves the systems throughput performance in different asymmetric level systems.