Miracle-dz/UniFAR-FTUs huggingface dataset:
Ilaprazole and Clopidogrel Resistance in Acute Stroke Patients

Clopidogrel, an antiplatelet agent used for secondary prevention of cerebrovascular diseases, is often taken with proton pump inhibitors (PPIs). Generally, the combined use of clopidogrel and PPIs causes adverse drug–drug interactions. VerifyNow is a quick and convenient method to confirm clopidogrel resistance (CR), which compromises adequate antithrombotic effects. We aimed to confirm CR, identify its factors, and determine the influence of the combination of ilaprazole and clopidogrel on clopidogrel using VerifyNow. In this retrospective study, we examined patients who were receiving clopidogrel after three months, starting within one week from the onset of cerebral infarction symptoms. Clinical records, imaging records, and diagnostic laboratory results, including P2Y12 reaction units (PRU), were compared and analyzed to check for CR. Additionally, the groups treated with either both ilaprazole and clopidogrel or with medications other than ilaprazole were comparatively analyzed. CR was defined as a PRU ≥240 after clopidogrel for three months. Among factors influencing CR by affecting clopidogrel metabolism, positive statistical correlations with age and alcohol consumption were confirmed. The diagnostic tests revealed a lower glomerular filtration rate and platelet count of the CR-positive group. This finding proved that the combination therapy of ilaprazole and clopidogrel is safe, as it does not interfere with the metabolism of clopidogrel.
Adapting Technology Adoption Model to detect intention to use tiket.com’s online ticketing application

The Technologies Adoption Model is a popular tool for determining whether or not a person intends to accept new technology. However, this paradigm is only used in a few research for internet-based interactive technologies. The authors argue that, in addition to perceived simplicity of use and utility, the application content has a significant influence in increasing use intention for this technology. Trust, not attitude, should play a role in the mediation, as described in the original plan. To verify this conceptual framework, the authors use WrapPLS to analyze data from 155 respondents using structural equation modeling. According to the findings, the three antecedents have a favorable and significant direct effect on purchase intent. It's also confirmed that trust has an indirect influence. Aside from the system's utility, confidence, and convenience of use, the authors advise that ticket vendors present intriguing application content. Future research can look into the aspects that determine how well the system works.
Evaluating sustainable energy harvesting systems for human implantable sensors

ABSTRACT Achieving most appropriate energy-harvesting technique for human implantable sensors is still challenging for the industry where keen decisions have to be performed. Moreover, the available polymeric-based composite materials are offering plentiful renewable applications that can help sustainable development as being useful for the energy-harvesting systems such as photovoltaic, piezoelectric, thermoelectric devices as well as other energy storage systems. This work presents an expert-based model capable of better evaluating and examining various available renewable energy-harvesting techniques in urban surroundings subject to various technical and economic, often conflicting, criteria. Wide evaluation criteria have been adopted in the proposed model after examining their suitability as well as ensuring the expediency and reliability of the model by worldwide experts’ feedback. The model includes establishing an analytic hierarchy structure with simultaneous 12 conflicting factors to establish a systematic road map for designers to better assess such techniques for human implantable medical sensors. The energy-harvesting techniques considered were limited to Wireless, Thermoelectric, Infrared Radiator, Piezoelectric, Magnetic Induction and Electrostatic Energy Harvesters. Results have demonstrated that the best decision was in favour of wireless-harvesting technology for the medical sensors as it is preferable by most of the considered evaluation criteria in the model.
Deriving Full‐Coverage and Fine‐Scale XCO2 Across China Based on OCO‐2 Satellite Retrievals and CarbonTracker Output

Due to the coarse spatial resolution, the column‐averaged dry‐air mole fraction of CO2 (XCO2) data from the CarbonTracker may be inadequate to reflect the spatial heterogeneity of XCO2. We developed a machine learning model to fill the data gaps in the Orbiting Carbon Observatory 2 satellite retrievals across China during 2015–2018, with cross‐validation R2 = 0.95 and RMSE = 0.91 ppm. Based on the gap‐filled data set, the multiyear average XCO2 was the highest in East China (405.71 ± 3.72 ppm) and the lowest in Northwest China (403.99 ± 3.47 ppm). At the national level, the multiyear seasonal XCO2 varied from 402.54 ± 3.95 ppm in summer to 406.28 ± 3.19 ppm in spring. While the XCO2 kept increasing, the rate of increase declined from 3.23 to 2.10 ppm/year. The machine learning approach is feasible for downscaling and calibrating the CarbonTracker XCO2 data. The full‐coverage and fine‐scale XCO2 data set is expected to advance our understanding of the carbon cycles.
THE IMPORTANCE OF THE MATHEMATICAL MODELING IN STEM EDUCATION

The science, technology, engineering, and mathematics (STEM) education model is very popular and used method in the recent years in most of the countries in the world. With STEM education at primary, secondary and high level the students acquire important skills, creativity, innovation, and entrepreneurship. For STEM integration and training different teaching methods can be used. The mathematical modeling is one of the most important methods which can be used at all educational levels. Mathematical modeling will be considered as a bridge to STEM education. Mathematical modeling, is the process of analyzing real-life or realistic situation using mathematical methods in the most general sense. The mathematical modeling cycles should be used in STEM education at all levels from primary to tertiary education in order to increase the students’ motivation towards learning mathematics for solving real-life problems.
Network properties and evolutionof the Hungarian RTGSover the past decade

Since the 2008 economic crisis, network research has become increasingly prominent in the world of finance. The complex interrelations and financial interdependencies formed among financial market participants have proved to be critical in times of crisis. In this paper, we explore the network properties of the Hungarian RTGS (VIBER) and also seek an answer to the question of whether the network properties of the system have changed over the long term across the time windows considered, and if so, to what extent. Furthermore, we identify systemically important participants using a variety of network theory tools. We also explore methodologies which – by providing new perspectives for monitoring the evolution of systemically important participants – may contribute to improving the effectiveness of oversight in Hungary. To identify systemically important participants, we apply four methodologies, namely: the LSI index, the model capturing the relation of eigenvector and betweenness, diffusion centrality, and the model exploring the effect of combining multiple nodes. In the Hungarian RTGS, two distinct groups emerge: the first is comprised of participants that play a key role in the transmission of liquidity (“core”), and the other is the cluster of periphery participants. As the composition of the core has remained virtually unchanged, it can be considered stable. While the risk of contagion arising from an operational disruption increased at both the individual and aggregated level during the period under review, it is also apparent that no such link exists in the graph the removal of which would ultimately cut the communication between the banks originally connected by it. The results of each indicator showed that there were no significant changes regarding the network properties across the three time windows, confirming the robustness of the network properties of the Hungarian RTGS and its stability over time.
The Reduction in Microtubule Arrays Caused by the Dysplasia of the Non-Centrosomal Microtubule-Organizing Center Leads to a Malformed Organ of Corti in the Cx26-Null Mouse

Mutations in the GJB2 gene account for approximately 20–50% of all non-syndromic hereditary deafness cases. The malformed organ of Corti (OC) was observed in different Cx26-null mouse models, which was mainly caused by the developmental arrest of pillar cells (PCs). However, the mechanism of developmental abnormalities in PCs caused by Cx26 deletion is still unclear. In this study, the ultrastructure of PCs at different postnatal days was observed in Cx26-null mice. Knockout of cochlear Cx26 led to the malformed assembly of non-centrosomal microtubule-organizing centers (MTOCs) far from the centrosome rather than near the centrosome. Additionally, the microtubule (MT) arrays emitted by abnormal non-centrosomal MTOCs were significantly reduced. In addition, we found that the protein expression of calmodulin-regulated, spectrin-associated protein2 (camsap2), a microtubule minus-end targeting protein associated with the organization of non-centrosomal MTs, was decreased in juvenile PCs in the Cx26-null group. Our results indicated that the malformation of non-centrosomal MTOCs in cochlear PCs might lead to the corresponding MTs’ failure to be captured and anchored in Cx26-null mice, which results in the deformity of OC. Additionally, this abnormal developmental process might be correlated with the reduced expression of camsap2 caused by Cx26 deletion in the early developmental stage.
Decision, intention, expectation, willingness, and volition: Critics and comments

There are thousands of studies aimed at predicting future behavior. The most outstanding concept in those quests is behavioral intention. However, many researchers fell into misusing those concepts, raising the inaccuracy of the prediction. Many researchers paid no considerable attention to the specific context of their study. This article aims to give the direction to avoid that trap and to straighten out the proper use of the concept of decision, goal intentions, specific intention, implementation, behavioral expectation, behavioral willingness, and volition. The author also outlines their relevance to a particular behavior. Original Article | Turnitin
Evaluation and Application of Environmental Value of Rural Land Resources Based on Improved GIS System

As the basis and material source of human production and life, land is an important part of natural resources. With the deepening of the concept of sustainable development, more and more attention has been paid to the sustainable development of land use. Reasonable assessment of land resources and environment is the premise of accelerating agricultural infrastructure construction, optimizing ecological environment construction, and rationally disposing land use structure. This paper proposes an evaluation method of rural land resources and environment based on the improved GIS system and takes Lingshan County as an example, based on the powerful spatial processing and rich spatial query and analysis capabilities of GIS, to analyze the current situation and sustainable development of its land use. It has established a representative and operable evaluation index system, which has certain reference significance for rural land and environmental evaluation.
Bioenergetic and Autophagic Characterization of Skin Fibroblasts from C9orf72 Patients

The objective of this study is to describe the alterations occurring during the neurodegenerative process in skin fibroblast cultures from C9orf72 patients. We characterized the oxidative stress, autophagy flux, small ubiquitin-related protein SUMO2/3 levels as well as the mitochondrial function in skin fibroblast cultures from C9orf72 patients. All metabolic and bioenergetic findings were further correlated with gene expression data obtained from RNA sequencing analysis. Fibroblasts from C9orf72 patients showed a 30% reduced expression of C9orf72, ~3-fold increased levels of oxidative stress and impaired mitochondrial function obtained by measuring the enzymatic activities of mitochondrial respiratory chain complexes, specifically of complex III activity. Furthermore, the results also reveal that C9orf72 patients showed an accumulation of p62 protein levels, suggesting the alteration of the autophagy process, and significantly higher protein levels of SUMO2/3 (p = 0.03). Our results provide new data reinforcing that C9orf72 cells suffer from elevated oxidative damage to biomolecules and organelles and from increased protein loads, leading to insufficient autophagy and an increase in SUMOylation processes.
Understanding the Effects and Impacts of Counter-Terrorist Financing Policy and Practice

ABSTRACT After twenty years of global counterterrorist financing (CTF) policy and practice, there is little consensus on what these have achieved, and little empirical evidence to determine if, or how, CTF works to reduce the financing of terrorism or terrorism more broadly. In many cases, the lack of clarity on these issues is due to poor articulation of the specific approaches to countering the financing of terrorism (CTF). The main approaches considered in the literature are the criminalization of terrorist financing and the financial exclusion (sanctions) approach, but there are many other identifiable policy approaches to CTF. In order to clarify our understanding of CTF, I examined over 550 pieces of scholarly literature covering both terrorist financing and CTF to develop a typology of seven main approaches to CTF, some of which have been studied and evaluated far more than others, but all of which are part of the “bucket” of policy options available to states. These different CTF approaches need to be considered and evaluated individually in order to design better policies and practices.
Systematic reinstatement of the Sumatra endemic species Mangiferasumatrana Miq. (Anacardiaceae)

﻿Abstract Mangiferasumatrana Miq. is an endemic species from Sumatra. The taxonomic status of M.sumatrana remains unclear and is currently treated as a synonym of M.laurina. The present study employed morphological and palynological characters and molecular analyses to address the delimitation between the two species. Pollen observations were carried out with a Scanning Electron Microscope (SEM). Phylogenetic relationships were investigated using the ITS and the trnl-F intergenic spacer markers. M.sumatrana differs from M.laurina by having pyramidal panicles with a low density of pale yellow flowers pale, sepals 3–3.5 × 1.7–2 mm, fruit roundish to flattened with pale yellow pulp, a rough fibre texture, and pollen with a prolate spheroidal shape. The MP phylogenetic tree showed a divergent boundary between the two species suggesting that M.sumatrana could be an independent species, not a variety of M.laurina. The present study supports the view that these two taxa can be treated as different species.
Magnetic Sulfonated Melamine-Formaldehyde Resin as an Efficient Catalyst for the Synthesis of Antioxidant and Antimicrobial Pyrazolone Derivatives

Sulfonated polymer-based materials, among heterogeneous catalysts, are frequently utilized in chemical transformations due to their outstanding chemical and physical durability. In this regard, a magnetic sulfonated melamine–formaldehyde resin (MSMF) catalyst was successfully prepared from a mixture of sulfonated melamine–formaldehyde and Fe3O4 nanoparticles in two steps. MSMF was used as a heterogeneous catalyst for the one-pot, three-component condensation of benzyl pyrazolyl naphthoquinones in water as a green solvent and 4-[(indol-3-yl)-arylmethyl]-1-phenyl-3-methyl-5-pyrazolones. The antimicrobial and antioxidant activities of catalyst, benzyl pyrazolyl naphthoquinones, and 4-[(indol-3-yl)-arylmethyl]-1-phenyl-3-methyl-5-pyrazolones were evaluated using agar disk-diffusion and DPPH assays, respectively. The antioxidant activity of the catalyst and 4-[(indol-3-yl)-arylmethyl]-1-phenyl-3-methyl-5-pyrazolones was found to be 75% and 90%, respectively. Furthermore, catalyst, benzyl pyrazolyl naphthoquinones, and 4-[(indol-3-yl)-arylmethyl]-1-phenyl-3-methyl-5-pyrazolones exhibited antimicrobial activity against Staphylococcus aureus and Escherichia coli. In conclusion, MSMF is a superior catalyst for green chemical processes, owing to its high catalytic activity, stability, and reusability.
Development of a XY z 3-DOF nanopositioning stage with linear displacement amplification device

The main purpose of this study is to develop a XYθZ 3-DOF nanopositioning stage with linear displacement amplification device. This stage is used by three groups of linear displacement amplification device to composition, and thus achieves precise XYθZ 3-DOF movement. The linear displacement amplification device makes use of a symmetrical layer mechanism, toggle amplification mechanism and parallel guiding spring to composition, and with amplification capability. Then it uses an equilateral triangle way to set the three groups of linear displacement amplification device. Overall design uses the finite element software ANSYS 12.0 to analysis the displacement, stress and dynamic response of nanopositioning stage. Experiment demonstrated takes the laser interferometer as the standard of displacement measurement. The result of experiment measurement shows that the maximum XY axis displacement and θZ rotational angle travel of the stage is 36. 5μm, 32μm and 265 arc sec.
I HAVE CHOSEN YOU AMONG THE OTHERS!: THE IMPACT OF LEADER-MEMBER EXCHANGE, PERCEIVED SUPERVISOR SUPPORT AND ORGRANIZATIONAL CITIZENSHIP BEHAVIOR IN ENHANCING SUBORDINATES’ PERFORMANCE IN HOSPITALITY INDUSTRY

Abstract: Covid-19 pandemic, which has occured for more than a year has had a bad impact on companies in Indonesia. This kind of condition urges superiors from the hospitality industry to immediately take some strategic steps to save their companies in order to survive. In such a situation, superiors are forced to select subordinates who should be retained or have to be released to reduce companies’ burden. For subordinates who are still retained by their superiors, it is due to good judgment from the superior so that these subordinates are still considered worthy enough of being retained and it is also hoped that the superior’s decision is correct by ensuring that these subordinates could show better working results. This study is conducted to add an empirical contribution to examine the role of LMX on PSS and OCB in improving subordinates’ performance, specifically in Indonesian context during Covid-19 pandemic. The data is collected from 264 respondents who work in the hospitality industry in East Java and Bali provinces, Indonesia. The results show that LMX has a positive and significant effect on OCB; LMX has a positive and significant effect on PSS; and PSS has a positive and significant effect on OCB; and finally OCB has a positive and significant effect on subordinates’ performance.Keywords: Leader-Member Exchange; Perceived Supervisor Support; Organizational Citizenship Behavior; Subordinates’ Performance; Hospitality Industry Abstrak: Pandemi Covid-19 yang terjadi lebih dari setahun membawa dampak buruk bagi perusahaan-perusahaan di Indonesia. Kondisi semacam ini mendesak para pimpinan dari industri perhotelan untuk segera mengambil beberapa langkah strategis untuk menyelamatkan perusahaannya agar tetap bertahan. Dalam situasi seperti itu, atasan terpaksa memilih bawahan yang harus dipertahankan atau harus dilepaskan untuk mengurangi beban perusahaan. Bagi bawahan yang masih dipertahankan oleh atasannya, hal ini dilatarbelakangi oleh penilaian yang baik dari atasan sehingga bawahan tersebut masih dianggap cukup layak untuk dipertahankan dan juga diharapkan keputusan atasan tersebut tepat dengan memastikan bahwa bawahan tersebut dapat menunjukkan kinerja yang lebih baik. Penelitian ini dilakukan untuk menambah kontribusi empiris untuk mengkaji peran pertukaran pemimpin-anggota pada perilaku kewarganegaran organisasi dalam meningkatkan kinerja bawahan, khususnya dalam konteks Indonesia di masa pandemi Covid-19. Data dikumpulkan dari 264 responden yang bekerja di industri perhotelan di provinsi Jawa Timur dan Bali, Indonesia. Hasil penelitian menunjukkan bahwa pertukaran pemimpin-anggota berpengaruh positif dan signifikan terhadap perilaku kewarganegaran organisasi; serta perilaku kewarganegaran organisasi juga berpengaruh positif dan signifikan terhadap kinerja bawahan.Kata kunci: Leader-member Exchange; Perceived Supervisor Support; Organizational Citizenship Behavior; Kinerja Bawahan; Industri Perhotelan
A Cu(II)-based coordination polymer: catalytic properties and treatment activity on stroke

ABSTRACT A fresh Cu(II) coordination polymer, i.e., [Cu3(Hmbdc)2(mbdc)2(dmphen)2]n (1, H2mbdc = isophthalic acid, dmphen = 4,7-dimethyl-1,10-phenanthroline), has been generated with the hydrothermal reactions between Cu salts and the mixed ligands of 4,7-dimethyl-1,10-phenanthroline and isophthalic acid. Moreover, the catalytic activity of 1 was evaluated via degrading the Congo red with a method of Fenton with an excellent degradation efficiency of 95.8% at 100 min. Next, the application value of compound on stroke was assessed, and the related mechanisms were explored at the same time. First of all, the tumor necrosis factor-α and recombinant rat IL-1β content released into the plasma were determined with enzyme-linked immunosorbent assay detection kit. Besides, the activation of the HMGB1/TLR4 signaling pathway activation in cerebral vascular endothelial cells was also determined with real-time reverse transcription–polymerase chain reaction assay.
Placental site trophoblastic tumour mimicking an intramural pregnancy: a case report and review of the literature

Gestational trophoblastic disease (GTD) covers a range of proliferative disorders from non-neoplastic hydatid moles to malignant neoplastic conditions such as choriocarcinoma. The incidence of these diseases is low and often challenging to diagnose. Placental site trophoblastic tumour (PSTT) is the rarest form of GTD, accounting for up to 3% of all cases. We present a case of a 35-year-old patient diagnosed with PSTT mimicking an intramural pregnancy. Placental site trophoblastic tumour occurred after pregnancy, which ended as a blighted ovum. β-hCG was not very high, and the patient had no complaints. The diagnosis was made after resection of formation which was accepted for intramural pregnancy. To our knowledge, this is the first such case described in the literature. A hysterectomy performed later confirmed the absence of a residual tumour after conservative intervention. The lack of distant metastases, confirmed by positron emission tomography-computed tomography scan, allowed for only hysterectomy with bilateral salpingo-oophorectomy to be performed. The patient was classified as low risk according to the World Health Organization (WHO) scoring system. Placental site trophoblastic tumour is a rare malignant tumour (despite its WHO coding) from the group of GTDs. It is not presented with a classic clinical picture, and its clinical diagnosis is challenging. However, clinicians should consider it in the case of unclear events after any type of pregnancy.