Miracle-dz/UniFAR-FTUs huggingface dataset:
Highly active bifunctional electrocatalyst: Nanoporous (Ni,Co)0.85Se anchored on rGO for water and hydrazine oxidation

It is an effective strategy to decrease water splitting overpotential by designing high‐performance oxygen evolution reaction (OER) electrocatalyst or substituting OER by hydrazine electrooxidation (HzOR). Herein, we fabricated bifunctional (Ni,Co)0.85Se/rGO with nanoporous structure via electrodeposition towards HzOR and OER. In comparison with (Ni,Co)0.85Se and NF, superior electrocatalytic activity and stability towards HzOR and OER were observed for (Ni,Co)0.85Se/rGO. The synergistic effects of (Ni,Co)0.85Se with rGO, high electrochemical surface area (ECSA), high electrical conductivity and the rapid release rate of bubbles from electrode surface induced by its superaerophobic result in superior performance of (Ni,Co)0.85Se/rGO. The OER process requires a low overpotential of 247 mV at 10 mA cm−2, and a high durability of 86.1% during 48 h long‐term test at 10 mA cm−2. When changing OER with HzOR, HzOR process can generate a high current density of 211 mA cm−2 at a potential of 0.2 V vs RHE, and a high stability of 92.3% after 24 h test at a high current density of 50 mA cm−2. This study displays a versatile, cost‐effective and industrial strategy to produce highly active catalysts for bifunctional application.
Vitamin D Treatment Prevents Uremia-Induced Reductions in Aortic microRNA-145 Attenuating Osteogenic Differentiation despite Hyperphosphatemia

In chronic kidney disease, systemic inflammation and high serum phosphate (P) promote the de-differentiation of vascular smooth muscle cells (VSMC) to osteoblast-like cells, increasing the propensity for medial calcification and cardiovascular mortality. Vascular microRNA-145 (miR-145) content is essential to maintain VSMC contractile phenotype. Because vitamin D induces aortic miR-145, uremia and high serum P reduce it and miR-145 directly targets osteogenic osterix in osteoblasts, this study evaluated a potential causal link between vascular miR-145 reductions and osterix-driven osteogenic differentiation and its counter-regulation by vitamin D. Studies in aortic rings from normal rats and in the rat aortic VSMC line A7r5 exposed to calcifying conditions corroborated that miR-145 reductions were associated with decreases in contractile markers and increases in osteogenic differentiation and calcium (Ca) deposition. Furthermore, miR-145 silencing enhanced Ca deposition in A7r5 cells exposed to calcifying conditions, while miR-145 overexpression attenuated it, partly through increasing α-actin levels and reducing osterix-driven osteogenic differentiation. In mice, 14 weeks after the induction of renal mass reduction, both aortic miR-145 and α-actin mRNA decreased by 80% without significant elevations in osterix or Ca deposition. Vitamin D treatment from week 8 to 14 fully prevented the reductions in aortic miR-145 and attenuated by 50% the decreases in α-actin, despite uremia-induced hyperphosphatemia. In conclusion, vitamin D was able to prevent the reductions in aortic miR-145 and α-actin content induced by uremia, reducing the alterations in vascular contractility and osteogenic differentiation despite hyperphosphatemia.
A Modified Pattern Sequence-Based Forecasting Method for Electricity Price

Electricity price forecasting is a relevant yet hard task in the field of one step time series forecasting. A new approach called Pattern Sequence-based Forecasting (PSF) shows a remarkable improvement in the time series prediction. The PSF consists of four steps: clustering, extraction pattern subsequence, sliding window to find similar subsequence, predicting. However, it doesn’t consider the characteristic of correlation which changes with the length of the time gap. In this paper, a modified machine learning method based on similarity of pattern sequences which is combined with the locally weighted linear regression, is proposed to forecast electricity prices. The main novelty is that the modified PSF consider the problem of correlation which changes the mean value into weighted mean value and the PSF is firstly used in the price forecasting track of the Global Energy Forecasting Competition 2014 which shows a significantly better performance. Keywords-locally weighted linear regression; pattern sequencebased forecasting (PSF); electricity price; time series forecasting
GNAQ and GNA11 Genes: A Comprehensive Review on Oncogenesis, Prognosis and Therapeutic Opportunities in Uveal Melanoma

Simple Summary The development of uveal melanoma is a multifactorial and multi-step process, in which specific and recurrent mutations arise early. Among the recurrently mutated genes, GNAQ and GNA11 are involved in the process of carcinogenesis and are mutated in 80–90% of these tumours. Historically, there has been speculation as to whether these two genes are involved in the progression of primary uveal melanoma to metastatic disease, in addition to the oncogenic process itself. For this reason, both genes have been the subject of multiple research studies. Additionally, due to their high mutation rate in uveal melanoma, these genes and the downstream signaling pathways in which they are involved have been postulated as interesting therapeutic targets. This review aims to provide a current comprehensive view of what we know about GNAQ and GNA11 genes on oncogenesis, prognosis and therapeutic opportunities in uveal melanoma. Abstract The GNAQ and GNA11 genes are mutated in almost 80–90% of uveal melanomas in a mutually exclusive pattern. These genes encode the alpha subunits of the heterotrimeric G proteins, Gq and G11; thus, mutations of these genes result in the activation of several important signaling pathways, including phospholipase C, and activation of the transcription factor YAP. It is well known that both of them act as driver genes in the oncogenic process and it has been assumed that they do not play a role in the prognosis of these tumours. However, it has been hypothesised that mutations in these genes could give rise to molecularly and clinically distinct types of uveal melanomas. It has also been questioned whether the type and location of mutation in the GNAQ and GNA11 genes may affect the progression of these tumours. All of these questions, except for their implications in carcinogenesis, remain controversial. Uveal melanoma has a distinctive genetic profile, and specific recurrent mutations, which make it a potential candidate for treatment with targeted therapy. Given that the most frequent mutations are those observed in the GNAQ and GNA11 genes, and that both genes are involved in oncogenesis, these molecules, as well as the downstream signalling pathways in which they are involved, have been proposed as promising potential therapeutic targets. Therefore, in this review, special attention is paid to the current data related to the possible prognostic implications of both genes from different perspectives, as well as the therapeutic options targeting them.
Mapping Crop Types of Germany by Combining Temporal Statistical Metrics of Sentinel-1 and Sentinel-2 Time Series with LPIS Data

Nationwide and consistent information on agricultural land use forms an important basis for sustainable land management maintaining food security, (agro)biodiversity, and soil fertility, especially as German agriculture has shown high vulnerability to climate change. Sentinel-1 and Sentinel-2 satellite data of the Copernicus program offer time series with temporal, spatial, radiometric, and spectral characteristics that have great potential for mapping and monitoring agricultural crops. This paper presents an approach which synergistically uses these multispectral and Synthetic Aperture Radar (SAR) time series for the classification of 17 crop classes at 10 m spatial resolution for Germany in the year 2018. Input data for the Random Forest (RF) classification are monthly statistics of Sentinel-1 and Sentinel-2 time series. This approach reduces the amount of input data and pre-processing steps while retaining phenological information, which is crucial for crop type discrimination. For training and validation, Land Parcel Identification System (LPIS) data were available covering 15 of the 16 German Federal States. An overall map accuracy of 75.5% was achieved, with class-specific F1-scores above 80% for winter wheat, maize, sugar beet, and rapeseed. By combining optical and SAR data, overall accuracies could be increased by 6% and 9%, respectively, compared to single sensor approaches. While no increase in overall accuracy could be achieved by stratifying the classification in natural landscape regions, the class-wise accuracies for all but the cereal classes could be improved, on average, by 7%. In comparison to census data, the crop areas could be approximated well with, on average, only 1% of deviation in class-specific acreages. Using this streamlined approach, similar accuracies for the most widespread crop types as well as for smaller permanent crop classes were reached as in other Germany-wide crop type studies, indicating its potential for repeated nationwide crop type mapping.
Substitution or Complementarity: Influence of Industry–University–Research-Institute Cooperation Governance Mechanism on Knowledge Transfer—An Empirical Analysis from China

China’s economic growth is transforming from being traditional and factor-driven to being innovation-driven. How to improve the independent innovation ability and build the sustainable competitiveness of enterprises through knowledge transfer in industry–university–research-institute (IUR) cooperation has become an urgent problem to be solved. The obstacles to knowledge transfer in an IUR cooperation include internal and external cooperation risk factors. Improving the governance mechanism of an IUR cooperation, reducing cooperation risks, and promoting knowledge transfer are effective means for overcoming such obstacles in the short term. Interorganizational governance mechanisms include contractual governance and relationship governance. Obvious differences exist in the target functions of the different types of governance mechanisms, and their effects on knowledge transfer also differ. Based on a questionnaire survey on the IUR cooperation innovation of 364 enterprises, this study discusses the impact of the contractual governance mechanism and relationship governance mechanism on knowledge transfer in the IUR cooperation. Different types of contractual governance mechanisms have different effects on knowledge transfer. The contractual coordination mechanism significantly promotes explicit knowledge transfer in an IUR cooperation but has no significant impact on tacit knowledge transfer, whereas the contractual control mechanism significantly promotes explicit knowledge transfer but hinders tacit knowledge transfer. Meanwhile, the relationship governance mechanism has a significant positive impact on explicit knowledge transfer and tacit knowledge transfer. The joint use of the contractual coordination mechanism and relationship governance mechanism can significantly promote explicit knowledge transfer and tacit knowledge transfer, whereas the joint use of the contractual control mechanism and relationship governance mechanism can significantly weaken the two types of knowledge transfer. This study provides not only a theoretical explanation for the dispute over the “complementarity” or “substitution” relationship between the contractual governance mechanism and relationship governance mechanism in knowledge transfer in an IUR cooperation, thereby enriching relationship governance theory and knowledge management theory, but also a reference to the government, enterprises, and universities/scientific institutions participating in an IUR cooperation.
Flux distribution inside the transformer core in short circuit

This paper shows results of experimental research on a scaled two winding single phase transformer model and FEM calculation of stray flux inside the core in short circuit test connection (load loss test). For the measurement purpose core was divided into 7 “packages” continuously along core’s cross section. Around each package 4 turns were wounded for flux distribution measurement. Stray flux distribution was observed in three positions along limb and yoke. Results have shown that an appreciable amount of stray flux appears inside the core even in the central packages. Flux distribution changes both in limb and yoke when power supply is changed from inner to outer winding. Comparison has shown that experimental results, representing flux density, correlate quite good with the results from FEM calculation.
Excited-state dynamics in electron-donor-acceptor systems of increasing complexity

Excitation energy transfer and charge separation are crucial steps in natural photosynthesis that allows the conversion of solar light into chemical energy. Understanding the nature of these processes is determinant for designing efficient synthetic analogues of these natural systems. This thesis describes ultrafast spectroscopic studies of the excited-state dynamics several systems, from simple molecules to multichromophoric systems, which are based on various chromophores arranged according to different motifs. To better understand the properties of these complex multichromophoric systems, systematic investigations of the individual units and model systems of different complexity have been performed. It allowed key factors enhancing the efficiency of excitation energy transfer and charge separation to be determined. The investigation of these processes in real time has been realized using various time-resolved techniques, which permit monitoring process occurring on timescale ranging from a few tens of femtosecond to several hundreds of microseconds.
Family Socioeconomic Status and Internalizing Problem Behavior Among Chinese Adolescents: The Chain Mediation Effect of Academic Performance and Peer Conflict

This study aims to provide a new perspective on the relationship between family socioeconomic status (SES) and internalizing problem behavior (IPB) among adolescents. Many studies have focused on the relationship between family SES and IPB among adolescents; however, research on the underlying mechanism is still insufficient, and peer conflict has been ignored as a crucial social relationship factor for adolescents. This study identifies two new mediating variables and a chain mediating mechanism model between them. Using national longitudinal data from 2,467 adolescents aged 10–15 published in the China Family Panel Studies of wave 2018, this study found the following: (1) higher family SES can significantly reduce peer conflict and IPB among adolescents; (2) adolescents with better academic performance were less likely to be involved in peer conflict; (3) peer conflict mediated 30.41% of the relationship between family SES and adolescent’s IPB; and (4) there was a chain mediating mechanism, and the mediating effect of peer conflict was much stronger than the mediating effect of both academic performance and the chain mediation pathways. This is the first study to develop a chain mediation model to examine the roles of academic achievement and peer conflict in the relationship between family SES and IPB. These findings are significant in that they highlight the importance of providing adolescents with proper emotional de-escalation and peer conflict resolution strategies, contributing to the management of adolescent mental health in urban governance and rural development.
The Antifreeze and Cryoprotective Activities of a Novel Antifreeze Peptide from Ctenopharyngodon idella Scales

The purpose of this study is to obtain new antifreeze peptides (AFPs) that are natural, safe, and high activity from Ctenopharyngodon idella scales. The optimal hydrolysis conditions were investigated, and chromatography-based isolation was conducted using thermal hysteresis activity (THA) as an index. Molecular dynamic simulation (MDs) was explored to reveal the antifreeze mechanism of the AFPs. The results showed that the optimal hydrolysis conditions were 4000 U/g papain enzyme for 60 °C at pH 5.0 and substrate concentration (1:10) for 3 h, as unveiled by single-factor experiment results. The AFPs documented a THA of 2.7 °C when the Th was 1.3 °C. Hydrophilic peptide, named GCFSC-AFPs, with a THA of 5.09 °C when the Th was 1.1 °C was obtained after a series isolation of gel filtration, ion exchange, and reversed-phase HPLC chromatography. The AFPs had a molecular weight of 1107.54~1554.72 Da with three main peptides in the amino acid sequence of VGPAGPSGPSGPQ, RGSPGERGESGPAGPSG, and VGPAGPSGPSGPQG, respectively. The survival rate of yeast with GCFSC-AFPs reached 84.4% following one week of exposure at −20 °C. MDs indicated that GCFSC-AFPs interfered with the ice-water interaction and thus inhibited the ice crystallization process. Our data suggested that the GCFSC-AFPs were a novel and potential antifreeze agent in the food industry.
Administrative philosophies in the discourse and decisions of the New Zealand public service: is post-New Public Management still a myth?

New Zealand is frequently cited as the archetypical example of New Public Management (NPM), having gone ‘further and faster’ than other jurisdictions in radically reforming their public service in the late 1980s. These reforms have been credited with significant gains in efficiency and responsiveness, while introducing new challenges. Successive reforms over the past 30 years tinkered with the model without fundamentally altering the underlying paradigm, such that authors refer to the ‘myth of post-NPM in New Zealand’. In 2020, New Zealand repealed and replaced its main public service legislation. By textually analysing government documents, this article explores the different theoretical roots of New Zealand's ongoing administrative reforms and debates the extent of their theoretical coherence. The Act directly dialogues with and draws inspiration from recent academic debates, drawing from a range of sources (such as New Public Governance, Digital Era Governance, and the New Public Service). Points for practitioners New Zealand has long been regarded as the purest example of New Public Management (NPM). Legislation passed in 2020 saw New Zealand adopt a range of reforms described in the literature as ‘post-NPM’, while also reaffirming features associated with Traditional Public Administration (TPA). While New Zealand has moved away from a pure NPM model and adopted features associated with Post-NPM, Post-NPM is not a coherent doctrine and it may only be possible to identify administrative doctrines retrospectively. We may be entering a period of ‘New Public Complexity’, where administrative doctrines are blended and layered.
Tellurium Nanotubes and Chemical Analogues from Preparation to Applications: A Minor Review

Tellurium (Te), the most metallic semiconductor, has been widely explored in recent decades owing to its fantastic properties such as a tunable bandgap, high carrier mobility, high thermal conductivity, and in-plane anisotropy. Many references have witnessed the rapid development of synthesizing diverse Te geometries with controllable shapes, sizes, and structures in different strategies. In all types of Te nanostructures, Te with one-dimensional (1D) hollow internal structures, especially nanotubes (NTs), have attracted extensive attention and been utilized in various fields of applications. Motivated by the structure-determined nature of Te NTs, we prepared a minor review about the emerging synthesis and nanostructure control of Te NTs, and the recent progress of research into Te NTs was summarized. Finally, we highlighted the challenges and further development for future applications of Te NTs.
Modern changes in the model of professional and pedagogical training of medicines in the context of European integration processes

Modern conditions of social development cause rethinking of the essence and goals of education, as a result of which the views on the professional activity of a specialist in the medical sphere and requirements to his personal qualities change. modernization of pedagogical conditions of future medical workers' professionalism formation is a requirement of modernity providing formation of competence and outlook professional characteristics of a future specialist, abilities to implement and improve his activity n Modernization of pedagogical conditions of future medical workers' professionalism formation consists in creating pedagogically comfortable, professionally-oriented educational environment; introduction of innovative educational technologies and interactive teaching methods; students' awareness of the role of professional competence in their activity, which is the result of the combined influence of needs and goals, motives and incentives, cognitive interests. An important stage of modernization of pedagogical conditions of future medics' formation is the creation of a pedagogically comfortable environment, including benevolent atmosphere, the situation of success, improvisation, which should become a trigger mechanism in a complex process of activation of future specialists' professional capabilities. The comfortable environment, each subject changes himself, changes the situation around himself, fills the educational environment with new knowledge, experience, ways of activity, forms new needs.
Greater In-Hospital Care and Early Rehabilitation Needs in People with COVID-19 Compared with Those without COVID-19

↔This study aims to compare the characteristics, in-hospital data and rehabilitation needs between those who tested positive versus negative for COVID-19 during hospitalisation with suspected COVID-19. In this cross-sectional study, a convenience sample of adults admitted to Western Australian tertiary hospitals with suspected COVID-19 was recruited. Participants were grouped according to their polymerase chain reaction (PCR) test result into COVID-19 positive (COVID+) and COVID-19 negative (COVID−) groups. Between-group comparisons of characteristics of the participants and hospital admission data were performed. Sixty-five participants were included (38 COVID+ and 27 COVID−; 36 females [55%]). Participants in the COVID+ group had greater acute hospital length of stay (LOS) (median [25–75th percentile] 10 [5–21] vs. 3 [2–5] days; p < 0.05] and only those with COVID+ required mechanical ventilation (8 [21%] participants). Twenty-one percent of the COVID+ participants were discharged to inpatient rehabilitation (7% of the COVID− participants). Of note, pre-existing pulmonary disease was more prevalent in the COVID− group (59% vs. 13%; p < 0.05). Within the COVID+ group, when compared to participants discharged home, those who required inpatient rehabilitation had worse peripheral oxygen saturation (SpO2) on admission (86 ± 5.7% vs. 93 ± 3.8%; p < 0.05) and longer median LOS (30 [23–37] vs. 7 [4–13] days; p < 0.05). Despite having less people with pre-existing pulmonary disease, the COVID+ group required more care and rehabilitation than the COVID− group. In the COVID+ group, SpO2 on hospital presentation was associated with LOS, critical care needs, mechanical ventilation duration and the need for inpatient rehabilitation.