Miracle-dz/UniFAR-FTUs huggingface dataset:
BRINE SHRIMP LETHALITY TEST AND ANTI-PROLIFERATION TEST AGAINST HUMAN CANCER- ORIGIN CELL LINES USING ETHANOLIC AND WATER EXTRACTS OF SELAGINELLADOEDERLEINII HIERON

Most of the properties of herbal products claimed in traditional use are based on traditional knowhow and/or empirical observations. Support from scientific evaluation and validation is thus crucial. Selaginella doederleinii HIERON is a member from the family of Selaginellaceae, a perennial, fern-like plant, and spike moss. It is known in traditional medicine to be useful to treat many diseases. However, proper scientific experimental results have not been reported thus far. The present study was conducted with the objectives of evaluating the phytochemical compositions, antimicrobial activities, and toxicity of the plant extracts . Qualitative phytochemical analysis on ethanolic (SDE) and water extracts (SDW) revealed the presence of saponins, tannins and cardiac glycosides in the extracts. The 50% lethal concentration (LC 50 ) in brine shrimp lethality test (BSLT) using SDE and SDW after 24 hours of exposure was found to be >1000µg/ml. Strong antimicrobial activity was observed against Escherichia coli , Pseudomonas aeruginosa , Staphylococcus aureus, Bacillus subtilus . Cancer-origin cell lines MDA-MB231 and HepG2 were found to be the most susceptible, among other tested cell lines, with the treatments of SDE (LC 50 =306 µg/ml) and SDW (LC 50 = 329 µg/ml) respectively. Amelioration with further subfractionation would increase the specific antiproliferation activities of these subfractions. Key words : Selaginella doederleinii, Brine shrimp, Anti-proliferative
Three-dimensional simulations of detonation propagation in circular tubes: Effects of jet initiation and wall reflection

In the present work, using a high-resolution three-dimensional numerical analysis, the initiation and propagation mechanism of a detonation wave is studied in a circular tube with a hot jet initiation. The reactive Euler equations with a one-step two-species chemistry model are solved based on the structured adaptive mesh refinement technique. Influences of both a single hot jet and impinging double hot jets on the formation of the detonation wave are studied. For each case, the objective is to investigate the role of the tube wall on the initiation and propagation of the detonation wave. The result for both cases shows that the hot jet-induced bow shock forms a complex reflection structure in the circular tube. The reflection effect of the circular wall strengthens the shock and facilitates the formation of the Mach stem, which leads to the formation of the detonation wave. However, when the hot jet condition and the total area of jet hole remain the same, for the case of initiation using double hot jets, the reflection strength of the bow shocks weakens when the diameters of the hot jets become smaller. When using a single hot jet, the initiated detonation is overdriven and propagates in the two-headed mode. In this initiation mode, by increasing the inflow Mach number, a four-headed mode detonation front is formed, while in the case of impinging double hot jets, a four-headed mode detonation front is initiated directly.
Multichannel behaviour in the retail industry: evidence from an emerging market

ABSTRACT With today’s proliferation of channel options, the retail industry should strive to provide a pleasurable experience to customers as they surf across different channels, in order to keep them connected. This study attempts to investigate channel choice in the retail industry in a multichannel environment. It examines the association between three sets of factors namely, psychographic factors, sociodemographic factors and channel experience factors and channel use for search versus purchase by customers. Data was drawn from a sample of 252 customers in the retail industry in Egypt and analysed using structural equation modelling using partial least squares (PLS-SEM). Significant differences were found with regards to psychographic, sociodemographic as well as channel experience factors, between customers who use channels for search and those who use them for purchase. With regards to psychographics, significant differences were found between customers who use channels for search vs. purchase in terms of (innovativeness, internet experience, perceived risk and time pressure). As for demographics (age and education) were significant factors, and as for channel experience factors (price advantage, trust and customisation) were significant factors distinguishing between channel use for search vs. purchase. This study provides useful insights for further research and managerial implications.
Studies of enzyme inhibitors and endochitinase in seeds of Job's Tears (Coix lachryma-jobi).

Studies of the purification, characterization and primary structure of protein inhibitors of trypsin and -amylase from seeds of Job's Tears (Coix lachryma-jobi) were undertaken. The major trypsin inhibitor from seeds of Coix was purified by heat treatment, fractional precipitation with ammonium sulphate, ion-exchange chromatography, gel filtration and preparative reversed-phase HPLC. The complete amino acid sequence was determined by analysis of peptides derived from the reduced and S- carboxymethylated protein by digestion with trypsin, chymotrypsin and the S.aureus V8 protease. The polypeptide contained 64 amino acids with a high content of cysteine. The sequence exhibited strong similarity with a number of Bowman-Birk inhibitors from legume and cereal seeds. A protein inhibitor of locust gut ζ-amylase was purified from seeds of Coix using ammonium sulphate precipitation, affinity chromatography on Red Sepharose and reversed-phase HPLC. It consisted of two major isomers, each a dimer of two identical or closely similar subunits of M(_r) about 26 400. These two isomers also had very similar amino acid compositions. The major isomer showed no inhibitory activity against amylases from other sources: human saliva, porcine pancreas, B. subtilis. A. oryzae and barley malt. The manual DABITC/PITC method was used to determine about half of the amino acid sequence of the major isoform. This showed a high degree of similarity with previously reported sequences of endochitinase enzymes from several species (tobacco, potato, barley, bean). Endochitinase activity was demonstrated by following the release of radioactivity from [(^3)H] chitin. As far as can be ascertained from the literature this is the first characterization of a plant protein with activity as an enzyme and as an enzyme inhibitor. Preliminary molecular studies were also carried out, including the isolation and in vitro translation of mRNA fractions from developing seeds of Coix.
No more Mr. Nice Guy: social value orientation and abusive supervision

The present research examined the interactive effect of subordinates' and their supervisors' social value orientations (SVO) on abusive supervision and its consequence for in-role performance. ,In study 1, we provided a survey to 420 subordinates and 115 supervisors from 42 organizations. HLM was used to test the hypothesized cross-level moderated mediation model. In study 2, 78 participants were asked to imagine they were a supervisor and responded to a potential scenario where supervisor and subordinate prosocial and proself orientations toward the organization were manipulated (2 × 2 design). ,Study 1 showed that when supervisors have a higher prosocial motivation, subordinates who are more self-interested (proself) report more abuse than those with a higher prosocial motivation, with negative consequences for in-role performance. Study 2 replicated the pattern: participants (in the role as supervisor) with induced prosocial goals rated abusive supervision behaviors as more justified and acceptable toward a proself employee than they did toward a prosocial employee. ,This research is innovative by bridging SVO and organizational literatures and demonstrating that a dyadic interaction between a proself subordinate and a prosocial supervisor may produce a reactive perpetrator – provocative victim relationship characterized by higher abusive supervision.
Development of an immortalised human hepatocyte cell line for the AMC Bio-Artificial Liver

Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva. nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.
Predicting Mechanical Properties and Corrosion Resistance of Heat-Treated 7N01 Aluminum Alloy by Machine Learning Methods

In this paper, mechanical properties and corrosion resistance of different heat-treated 7N01 aluminum alloys are measured. A novel approach is proposed to establish the relationship between heat-treated processing parameters and the properties using machine learning methods. With a set of trustable data, generalized regression neural network (GRNN), support vector machine (SVM) and multiple linear regression (MLR) are applied in the prediction of mechanical properties, while GRNN and SVM, two prevalent machine learning methods, are also employed to predict the corrosion resistance. By comparing coefficient of determination (R2) and mean absolute percentage error (MAPE), we demonstrate, GRNN and SVM are indeed useful machine leaning methods for both modeling and predicting. In virtue of the new approach, we can also establish other goal-oriented models for design and prediction as long as the training data set is available. Finally, it’s found that both single-stage aging and retrogression re-aging can make the alloy reach higher strength values than double-stage aging, however the corrosion resistance of double-stage aging alloy is better than that of single-stage aging.
Bim-Based Artificial Engineering Integration Method for Building Engineering Database

In order to perfect the database system of building engineering and meet the demand of data processing and integration, a BIM - based artificial intelligence system integration research method of building engineering database was designed. The role of artificial intelligence integration method in building engineering database system was deeply analyzed, based on which the effectiveness of BIM based artificial intelligence integration method in building engineering database was further discussed. After experimental verification, the bim-based artificial intelligence integration method of building engineering database was more conducive to further improving the efficiency of architectural engineering, effectively reducing the design cycle of architectural engineering and realizing the optimization design of architectural engineering. And its integration efficiency was about 30% higher than the traditional integration method.
Design and implementation of fuzzy controllers for complex systems - case study: a water desalination plant

Two soft computing paradigms for automated learning control of complex systems are briefly de scribed. To illustrate the utility of the paradigms, they are applied to a desalination process and sim ulations are performed. The first paradigm in corporates Genetic Algorithms (GA) in a learn ing scheme to adapt parameters of the fuzzy controller to changing environmental conditions. The second paradigm concentrates on a methodology which uses a Neural Network (NN) to adapt a fuzzy logic controller. Simulation results of fuzzy controllers learned with the aid of these soft computing paradigms are presented.
The Inheritance of Coat Color in Dogs

Feel lonely? What about reading books? Book is one of the greatest friends to accompany while in your lonely time. When you have no friends and activities somewhere and sometimes, reading book can be a great choice. This is not only for spending the time, it will increase the knowledge. Of course the b=benefits to take will relate to what kind of book that you are reading. And now, we will concern you to try reading inheritance of coat color in dogs as one of the reading material to finish quickly.
A survey of digital circuit testing in the light of machine learning

The insistent trend in today's nanoscale technology, to keep abreast of the Moore's law, has been continually opening up newer challenges to circuit designers. With rapid downscaling of integration, the intricacies involved in the manufacturing process have escalated significantly. Concomitantly, the nature of defects in silicon chips has become more complex and unpredictable, adding further difficulty in circuit testing and diagnosis. The volume of test data has surged and the parameters that govern testing of integrated circuits have increased not only in dimension but also in the complexity of their correlation. Evidently, the current scenario serves as a pertinent platform to explore new test solutions based on machine learning. In this survey, we look at various recent advances in this evolving domain in the context of digital logic testing and diagnosis.
Physics-informed Neural Network: The Effect of Reparameterization in Solving Differential Equations

Differential equations are used to model and predict the behaviour of complex systems in a wide range of fields, and the ability to solve them is an important asset for understanding and predicting the behaviour of these systems. Complicated physics mostly involves difficult differential equations, which are hard to solve analytically. In recent years, physics-informed neural networks have been shown to perform very well in solving systems with various differential equations. The main ways to approximate differential equations are through penalty function and reparameterization. Most researchers use penalty functions rather than reparameterization due to the complexity of implementing reparameterization. In this study, we quantitatively compare physics-informed neural network models with and without reparameterization using the approximation error. The performance of reparameterization is demonstrated based on two benchmark mechanical engineering problems, a one-dimensional bar problem and a two-dimensional bending beam problem. Our results show that when dealing with complex differential equations, applying reparameterization results in a lower approximation error.
Insights into Shugoshin localization and function in S. cerevisiae chromosome segregation

Faithful chromosome segregation is crucial to the well being of organisms. In mitosis, the partitioning of chromosomes to daughter cells is monitored at many levels to ensure that identical genomic information is received. Meiosis is a specialized form of cell division during which two division phases follow replication of the genome. Several steps are taken in meiosis to allow for a unique pattern of chromosome segregation. Homologous chromosomes segregate during the first division and sister chromatids segregate during the second. Cohesins, protein complexes that associate along the length of chromosomes during DNA replication, are lost in a step-wise manner in meiosis. During the first division, cohesins are lost only along chromosome arms. Cohesins remain at centromeres during meiosis II and are required to establish proper orientation of sister chromatid kinetochores. Shugoshin (Sgol) is a protein related to D. melanogaster Mei-S332 that is crucial for the protection of centromeric cohesins from cleavage until anaphase II of meiosis. Here we show that in S. cerevisiae cohesins are protected from cleavage during meiosis I in a 50 kb region of chromosomes and Sgol localizes to cohesin-associated regions within this region. Interestingly, there is no sequence specificity to the region of Sgol association. Instead, it is the proximity of this region to the centromere that causes enhanced cohesin and Sgol localization. We also characterize a role for Sgol in chromosome segregation that is independent of its role in cohesin regulation. Sgol helps ensure that kinetochores are oriented correctly in both mitosis and meiosis and is required to prevent chromosome segregation errors and spindle elongation in the absence of cohesin cleavage. Finally, our data suggest a possible role for Sgol in biasing sister kinetochores toward bi-orientation during the mitotic divisions. Thus, Sgol is a centromeric protein with a cell cycle role that includes both regulations of cohesins and kinetochore orientation. Thesis Supervisor: Angelika Amon Title: Professor of Biology
Tropical Wetland (TropWet) Mapping Tool: The Automatic Detection of Open and Vegetated Waterbodies in Google Earth Engine for Tropical Wetlands

Knowledge of the location and extent of surface water and inundated vegetation is vital for a range of applications including flood risk management, biodiversity monitoring, quantifying greenhouse gas emissions, and mapping water-borne disease risk. Here, we present a new tool, TropWet, which enables users of all abilities to map wetlands in herbaceous dominated regions based on simple unmixing of optical Landsat satellite imagery in the Google Earth Engine. The results demonstrate transferability throughout the African continent with a high degree of accuracy (mean 91% accuracy, st. dev 2.6%, n = 10,800). TropWet demonstrated considerable improvements over existing globally available surface water datasets for mapping the extent of important wetlands like the Okavango, Botswana. TropWet was able to provide frequency inundation maps as an indicator of malarial mosquito aquatic habitat extent and persistence in Barotseland, Zambia. TropWet was able to map flood extent comparable to operational flood risk mapping products in the Zambezi Region, Namibia. Finally, TropWet was able to quantify the effects of the El Niño/Southern Oscillation (ENSO) events on the extent of photosynthetic vegetation and wetland extent across Southern Africa. These examples demonstrate the potential for TropWet to provide policy makers with crucial information to help make national, regional, or continental scale decisions regarding wetland conservation, flood/disease hazard mapping, or mitigation against the impacts of ENSO.
A 20‐Year Climatology of Madden‐Julian Oscillation Convection: Large‐Scale Precipitation Tracking From TRMM‐GPM Rainfall

This study presents a 20‐year climatology of the Madden‐Julian Oscillation (MJO) convection based on Large‐scale Precipitation Tracking (LPT) using TRMM‐GPM Multisatellite Precipitation Analysis (TMPA) data from 1998–2018 over the global tropics‐midlatitudes (50°S–50°N). A total of 215 convective events are identified as MJO LPT systems over the 20 years, extending the results of Kerns and Chen (2016, https://doi.org/10.1002/2015JD024661). MJO LPT systems provide quantitative information regarding size, intensity, and location of the MJO convection in both the longitudinal and meridional directions. The MJO contributes up to 40–50% of the annual precipitation over the tropical Indo‐Pacific warm pool. MJO LPT systems have distinct seasonal and interannual variability. While MJO LPT systems are generally confined over the equatorial tropics during Boreal winter, some MJO LPT systems propagate northeast in the Bay of Bengal or from the South China Sea to the western North Pacific during Boreal summer. MJO LPT systems are more than doubled over the Indian Ocean (IO) and Maritime Continent (MC) during La Nina compared to El Nino. The 63% of MJO LPT systems initiate over the tropical IO, 26% over the MC and western Pacific, and 11% from the central Pacific to South America. About 40% of the MJO LPT systems that initialized over the IO were unable to propagate through the MC, namely, the barrier effect. The MC barrier effect is most pronounced during the spring and autumn transitions. This 20‐year MJO LPT climatology product will be provided as a supplement to this publication.
The evolution of superharmonics excited by internal tides in non-uniform stratification

A weakly nonlinear time-dependent theory for the evolution of superharmonics generated by the nonlinear self-interaction of a mode-1 internal tide in non-uniform stratification is developed and compared to numerical simulations. The forcing by the internal tide is found to excite near-pure mode-1 superharmonics whose natural frequency is moderately different from twice the internal tide frequency. Consequently, the superharmonics undergo a slow periodic growth and decay that is comparable to an acoustic ‘beat’. At low latitudes the beat frequency is smaller and the superharmonics can grow to larger amplitude, allowing for the possibility of a superharmonic cascade.
Management of bovine tuberculosis in brushtail possums in New Zealand: predictions from a spatially explicit, individual‐based model

Summary 1. Bovine tuberculosis Mycobacterium bovis (Tb) in brushtail possums Trichosurus vulpecula in New Zealand continues to pose a threat to the livestock industry. While significant reductions in cattle reactor rates have been achieved by widespread possum control, there is still a need for significant improvement, particularly in relation to limiting the further spread of the disease. 2. A recently developed oral Tb vaccine based on bacille Calmette–Guerin (BCG) offers a possible alternative to poison baiting for widespread disease control in possums. In addition, there is ongoing development of orally delivered fertility control vaccines (FC) as an alternative method for possum control. However, there is some doubt about whether control strategies based on oral BCG or FC can offer cost-effective solutions for disease control in possums. 3. We developed a spatially explicit, individual-based model (IBM) of Tb in possums to address perceived shortcomings in existing non-spatial models, particularly their failure to model realistically the spatial scale of transmission. The spatial IBM was also used to compare the cost-effectiveness of control strategies using BCG and combined BCG/FC to existing strategies based on lethal control. In particular, we explored the effectiveness of strategies to contain a localized outbreak. 4. Considering the cumulative cost of control to contain a localized Tb outbreak, the most cost-effective strategy combined an initial cull of possums with both BCG and FC applied every 3 years. In addition, the combined culling/BCG/FC strategy required only a 2- to 3-km control buffer around the outbreak site to achieve successful containment. By comparison, control strategies that used BCG or BCG/FC alone were not as cost-effective as they required at least a 5-km buffer around the outbreak site to achieve containment. 5. Synthesis and applications. Current strategies for Tb control in possums rely heavily on lethal control techniques, but there is public antipathy in New Zealand to the widespread use of toxicants for pest control. Strategies for Tb control that use oral vaccination of possums with BCG, or combined BCG/FC, in combination with a single initial cull of the population offer a cost-effective alternative for local eradication and containing disease spread. Such strategies would greatly reduce the need for repeated application of toxicants.