Miracle-dz/UniFAR-FTUs huggingface dataset:
“One Size Does Not Fit All:” A Proposed Ecological Model for Human Trafficking Intervention

ABSTRACT The problem of human trafficking continues to be one of the vilest human rights abuse and manifestation of social injustice around the world. A lot of antitrafficking efforts have been put in place. However, there is still a lot of emphasis on the criminal aspect of the problem. This has meant that human and practical aspects of the problem have not received sufficient attention, including assessing the problem, victims, and perpetrators in their environments. The ecological perspective helps practitioners, researchers, and policy makers to better understand the problem. This article uses the main concepts in this theory to frame the problem. Discussions are directed toward understanding the different aspects of the problem from an ecological perspective.
The effect of pre‐operative gastric ultrasound examination on the choice of general anaesthetic induction technique for non‐elective paediatric surgery. A prospective cohort study

Ultrasound examination of the gastric antrum is a non‐invasive tool that allows reliable estimation of gastric contents. We performed this prospective cohort study in non‐elective paediatric surgery to assess whether gastric ultrasound may help to determine the best anaesthetic induction technique, whether rapid sequence or routine. The primary outcome was the reduction of inappropriate induction technique. A pre‐operative clinical assessment was performed by the attending anaesthetist who made a provisional plan for induction. Gastric ultrasound was performed in the semirecumbent and right lateral decubitus positions for a qualitative assessment of gastric contents, using a 0–2 grading scale. A final induction plan was made based on this assessment. Immediately after tracheal intubation, gastric contents were suctioned through a multi‐orifice nasogastric tube; these were defined as above risk threshold for regurgitation and aspiration if there was clear fluid > 0.8 ml.kg−1, and/or the presence of thick fluid and/or solid particles. Gastric ultrasound was feasible in 130 out of 143 (90%) of children, and led to a change in the planned induction technique in 67 patients: 30 from routine to rapid sequence, and 37 from rapid sequence to routine. An appropriate induction technique was therefore performed in 85% of children, vs. 49% planned after pre‐operative clinical assessment alone (p < 0.00001). Our results suggest that gastric ultrasound is a useful guide to the general anaesthetic induction technique with respect to the risk of pulmonary aspiration, in comparison with pre‐operative clinical assessment alone.
Measuring the gender discrimination: A machine learning approach

Gender discrimination is a widely analyzed problem, which seems to affect different countries and cultures over time. Nowadays, we are witnesses of the social inequality reflected by the salary difference between women and men for the same employment. Since the incorporation of women into the labor market in the 1980s, the wage gap between males and females has been a subject of study. One of the traditional arguments has been linked to the feminized occupations associated with sex stereotypes, as well as, low wage, birth, and discrimination in the labor categories. In the present work, we apply clustering algorithms to the PHOGUE dataset to analyze salary difference between males and females in Spain and England.
Health literacy among older persons in Turkey

Abstract Aim: The aim of this study was to investigate the health literacy and cognitive functions of individuals age 65 and over and the relationship between them. Method: The research was conducted between September 2016 and February 2017, among individuals age 65 and over, at the Family Health Center. The participants were given the Health Literacy Survey – European Union (HLS-EU) scale and the Mini-Mental Test. Results: In this sampling, health literacy was found as “problematic or inadequate” in 85.1% of the elderly population. Among the health literacy issues, rate of “problematic-inadequate” results was 63.5% in benefiting from health services, 86.9% in protection from diseases, and 87.6% in improvement of health. The issues that older persons feel most inadequate were adult vaccinations and periodic examinations and they felt sufficient in terms of what to do in emergency cases. Conclusion: The older population needs support in health literacy issues particularly related to judgments. It would be appropriate to set up a standard care algorithm in older people.
Robotics in MRI-Guided Interventions

Abstract Robots have been found to be a useful tool in magnetic resonance imaging (MRI)-guided intervention. The utility of robots in MRI-guided therapy ranges from aid for precision targeting to high-dexterity surgical tools to improve or even enable new MRI-guided therapy options. The objective of this article is to review the technical aspects of robotics in MRI-guided interventions, highlight the role of MRI robots in prostate interventions, and finally discuss the future contribution of emerging robotics technology useful in MRI-guided intervention.
Gyrocompassing mode of the strapdown inertial navigation system

A gyrocompassing mode of the strapdown inertial navigation systems (SINS) was presented. SINS has been composed of Inertial Measurement Unit (IMU) and navigation computer. IMU consists of triad accelerometers, gyroscopes and a circuit of signal processing. It is received a full expression for the error of gyrocompassing depending from errors of gyroscope, accelerometers and latitude source. It was estimated the errors of gyroscope and accelerometers on the assumption of the required the error of gyrocompassing. Also, it is shown that calibration results are effected to the error of gyrocompassing. It is brought the simulation results of impact any factors such as bias instability of gyroscopes, scale factor instability of gyroscopes, bias instability of accelerometers, scale factor instability of accelerometers, and misalignment of measurement frame axes onto the error of gyrocompassing mode. It is shown that maximum influence on to the error of gyrocompassing mode has got the bias instability of gyroscopes.
Do Elderly Choose Nursing Homes by Quality, Price or Location?

Quality report cards addressing information asymmetry in the health care market have become a popular strategy used by policymakers to improve the quality of care for elderly. Using individual level data from the largest German sickness fund merged with institutional level data, we examine the relationship between nursing home quality, as measured by recently introduced report cards, nursing home prices, nursing home's location and the individual choice of nursing homes. Report cards were stepwise introduced as of 2009 and we use a sample of 2010 that includes both homes that had been evaluated at that time and that had not yet been. Thus, we can distinguish between institutions with good and bad ratings as well as non-rated nursing homes. We find that the probability of choosing a nursing home decreases in distance and price. However, we find no significant effect of reported quality on individuals' choice of nursing homes.
Parental and Self-Weight Perceptions in U.S. Children and Adolescents, NHANES 2005-2014

This study aimed to describe the parental and child self-weight perceptions and their associated sociodemographic factors. The 2005-2014 National Health and Nutrition Examination Survey (NHANES) sample of 16,869 children aged 2 to 17 years was used. For overweight/obese children aged 2 to 15 years, 61.2% of parents underestimated their child’s weight. For overweight/obese children aged 8 to 17 years, 55.2% underestimated their own weight. For children aged 8 to 15 years, 77.8% parents and children agreed on the weight classification. Parents of boys and those with low income were more likely to underestimate their child’s weight. Girls, older children, and those living in larger or high-income families were less likely to underestimate their own weight. Hispanic and Black children tended to underestimate their weight. With increasing child age, parents and children were more likely to disagree on the child’s weight. Future efforts should focus on low-income families with larger number of children and Hispanic and Black young children who were more likely to underestimate their weight.
Can we map the interannual variability of the whole upper Southern Ocean with the current database of hydrographic observations

With the advent of Argo floats, it now seems feasible to study the interannual variations of upper ocean hydrographic properties of the historically undersampled Southern Ocean. To do so, scattered hydrographic profiles often first need to be mapped. To investigate biases and errors associated both with the limited space-time distribution of the profiles and with the mapping methods, we colocate the mixed-layer depth (MLD) output from a state-of-the-art 1/12° DRAKKAR simulation onto the latitude, longitude, and date of actual in situ profiles from 2005 to 2014. We compare the results obtained after remapping using a nearest neighbor (NN) interpolation and an objective analysis (OA) with different spatiotemporal grid resolutions and decorrelation scales. NN is improved with a coarser resolution. OA performs best with low decorrelation scales, avoiding too strong a smoothing, but returns values over larger areas with large decorrelation scales and low temporal resolution, as more points are available. For all resolutions OA represents better the annual extreme values than NN. Both methods underestimate the seasonal cycle in MLD. MLD biases are lower than 10 m on average but can exceed 250 m locally in winter. We argue that current Argo data should not be mapped to infer decadal trends in MLD, as all methods are unable to reproduce existing trends without creating unrealistic extra ones. We also show that regions of the subtropical Atlantic, Indian, and Pacific Oceans, and the whole ice-covered Southern Ocean, still cannot be mapped even by the best method because of the lack of observational data.
Osteopontin Promotes Protective Antigenic Tolerance against Experimental Allergic Airway Disease

In the context of inflammation, osteopontin (Opn) is known to promote effector responses, facilitating a proinflammatory environment; however, its role during antigenic tolerance induction is unknown. Using a mouse model of asthma, we investigated the role of Opn during antigenic tolerance induction and its effects on associated regulatory cellular populations prior to disease initiation. Our experiments demonstrate that Opn drives protective antigenic tolerance by inducing accumulation of IFN-β–producing plasmacytoid dendritic cells, as well as regulatory T cells, in mediastinal lymph nodes. We also show that, in the absence of TLR triggers, recombinant Opn, and particularly its SLAYGLR motif, directly induces IFN-β expression in Ag-primed plasmacytoid dendritic cells, which renders them extra protective against induction of allergic airway disease upon transfer into recipient mice. Lastly, we show that blockade of type I IFNR prevents antigenic tolerance induction against experimental allergic asthma. Overall, we unveil a new role for Opn in setting up a tolerogenic milieu boosting antigenic tolerance induction, thus leading to prevention of allergic airway inflammation. Our results provide insight for the future design of immunotherapies against allergic asthma.
Deletion of IRF8 (Interferon Regulatory Factor 8)-Dependent Dendritic Cells Abrogates Proatherogenic Adaptive Immunity

Rationale: Despite an established role for adaptive immune responses in atherosclerosis, the contribution of dendritic cells (DCs) and their various subsets is still poorly understood. Objective: Here, we address the role of IRF8 (interferon regulatory factor 8)-dependent DCs (lymphoid CD8&agr;+ and their developmentally related nonlymphoid CD103+ DCs) in the induction of proatherogenic immune responses during high fat feeding. Methods and Results: Using a fate-mapping technique to track DCs originating from a DNGR1+ (dendritic cell natural killer lectin group receptor 1) precursor (Clec9a+/creRosa+/EYFP mice), we first show that YFPhiCD11chiMHCIIhi (major histocompatibility complex class II) DCs are present in the atherosclerotic aorta of low-density lipoprotein receptor–deficient (Ldlr−/−) mice and are CD11b–CD103+IRF8hi. Restricted deletion of IRF8 in DCs (Irf8flox/floxCd11cCre) reduces the accumulation of CD11chiMHCIIhi DCs in the aorta without affecting CD11b+CD103– DCs or macrophages but completely abolishes the accumulation of aortic CD11b–CD103+ DCs. Lymphoid CD8&agr;+ DCs are also deleted. This is associated with a significant reduction of aortic T-cell accumulation and a marked reduction of high-fat diet–induced systemic T-cell priming, activation, and differentiation toward T helper type 1 cells, T follicular helper cells, and regulatory T cells. As a consequence, B-cell activation and germinal center responses to high-fat diet are also markedly reduced. IRF8 deletion in DCs significantly reduces the development of atherosclerosis, predominantly in the aortic sinus, despite a modest increase in total plasma cholesterol levels. Conclusions: IRF8 expression in DCs plays a nonredundant role in the development of proatherogenic adaptive immunity.
Neuroinflammation of the spinal cord and nerve roots in chronic radicular pain patients

Abstract Numerous preclinical studies support the role of spinal neuroimmune activation in the pathogenesis of chronic pain, and targeting glia (eg, microglia/astrocyte)- or macrophage-mediated neuroinflammatory responses effectively prevents or reverses the establishment of persistent nocifensive behaviors in laboratory animals. However, thus far, the translation of those findings into novel treatments for clinical use has been hindered by the scarcity of data supporting the role of neuroinflammation in human pain. Here, we show that patients suffering from a common chronic pain disorder (lumbar radiculopathy), compared with healthy volunteers, exhibit elevated levels of the neuroinflammation marker 18 kDa translocator protein, in both the neuroforamina (containing dorsal root ganglion and nerve roots) and spinal cord. These elevations demonstrated a pattern of spatial specificity correlating with the patients' clinical presentation, as they were observed in the neuroforamen ipsilateral to the symptomatic leg (compared with both contralateral neuroforamen in the same patients as well as to healthy controls) and in the most caudal spinal cord segments, which are known to process sensory information from the lumbosacral nerve roots affected in these patients (compared with more superior segments). Furthermore, the neuroforaminal translocator protein signal was associated with responses to fluoroscopy-guided epidural steroid injections, supporting its role as an imaging marker of neuroinflammation, and highlighting the clinical significance of these observations. These results implicate immunoactivation at multiple levels of the nervous system as a potentially important and clinically relevant mechanism in human radicular pain, and suggest that therapies targeting immune cell activation may be beneficial for chronic pain patients.
β3-Adrenoceptor Impairs Mitochondrial Biogenesis and Energy Metabolism During Rapid Atrial Pacing-Induced Atrial Fibrillation

Background: The β3-adrenoceptor (β3-AR) is implicated in cardiac remodeling. Since metabolic dysfunction due to loss of mitochondria plays an important role in heart diseases, we examined the effects of β3-AR on mitochondrial biogenesis and energy metabolism in atrial fibrillation (AF). Methods: Atrial fibrillation was created by rapid atrial pacing in adult rabbits. Rabbits were randomly divided into 4 groups: control, pacing (P7), β3-AR antagonist (L748337), and β3-AR agonist (BRL37344) groups. Atrial effective refractory period (AERP) and AF induction rate were measured. Atrial concentrations of adenine nucleotides and phosphocreatine were quantified through high-performance liquid chromatography. Mitochondrial DNA content was determined. Real-time polymerase chain reaction and Western blot were used to examine the expression levels of signaling intermediates related to mitochondrial biogenesis. Results: After pacing for 7 days, β3-AR was significantly upregulated, AERP was reduced, and the AF induction rate was increased. The total adenine nucleotides pool was significantly reduced due to the decrease in adenosine triphosphate (ATP). The P7 group showed decreased activity of F0F1-ATPase. Mitochondrial DNA content was decreased and mitochondrial respiratory chain subunits were downregulated after pacing. Furthermore, expression of transcription factors involved in mitochondrial biogenesis, including peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), nuclear respiratory factor 1 (NRF-1), and mitochondrial transcription factor A (Tfam), was lower in the P7 group in response to β3-AR activation. Further stimulation of β3-AR with BRL37344 exacerbated these effects, together with a significant decrease in the levels of phosphocreatine. In contrast, inhibition of β3-AR with L748337 partially restored mitochondrial biogenesis and energy metabolism of atria in the paced rabbits. Conclusion: The activation of β3-AR contributes to atrial metabolic remodeling via transcriptional downregulation of PGC-1α/NRF-1/Tfam pathway that are involved in mitochondrial biogenesis, which ultimately perturbs mitochondrial function in rapid pacing-induced AF. The β3-AR is therefore a potential novel therapeutic target for the treatment or prevention of AF.
Diploptene δ 13 C values from contemporary thermokarst lake sediments show complex spatial variation

Abstract. Cryospheric changes in northern high latitudes are linked to significant greenhouse gas flux to the atmosphere, for example, methane that originates from organic matter decomposition in thermokarst lakes. The set of pathways that link methane production in sediments, via oxidation in the lake system, to the flux of residual methane to the atmosphere is complex and exhibits temporal and spatial variation. The isotopic signal of bacterial biomarkers (hopanoids, e.g. diploptene) in sediments has been used to identify contemporary ocean-floor methane seeps and, in the geological record, periods of enhanced methane production (e.g. the PETM). The biomarker approach could potentially be used to assess temporal changes in lake emissions through the Holocene via the sedimentary biomarker record. However, there are no data on the consistency of the signal of isotopic depletion in relation to source or on the amount of noise (unexplained variation) in biomarker values from modern lake sediments. We assessed methane oxidation as represented by the isotopic signal of biomarkers from methane oxidising bacteria (MOB) in multiple surface sediment samples in three distinct areas known to emit varying levels of methane in two shallow Alaskan thermokarst lakes. Diploptene was present and had δ13C values lower than −38 ‰ in all sediments analysed, suggesting methane oxidation was widespread. However, there was considerable variation in δ13C values within each area. The most 13C-depleted diploptene was found in an area of high methane ebullition in Ace Lake (diploptene δ13C values between −68.2 and −50.1 ‰). In contrast, significantly higher diploptene δ13C values (between −42.9 and −38.8 ‰) were found in an area of methane ebullition in Smith Lake. δ13C values of diploptene between −56.8 and −46.9 ‰ were found in the centre of Smith Lake, where ebullition rates are low but diffusive methane efflux occurs. The small-scale heterogeneity of the samples may reflect patchy distribution of substrate and/or MOB within the sediments. The two ebullition areas differ in age and type of organic carbon substrate, which may affect methane production, transport, and subsequent oxidation. Given the high amount of variation in surface samples, a more extensive calibration of modern sediment properties, within and among lakes, is required before down-core records of hopanoid isotopic signatures are developed.
Improving the efficacy of PET‐CT imaging in head and neck cancer management and surveillance through the multidisciplinary team: A multicentre, retrospective cohort analysis of 51 patients

There has been a recent move towards image-guided surveillance of N2/N3 disease in HNSCC and neck dissection only in selected cases PET-CT demand is rising and alters management in a third of HNSCC patients PET-CT is expensive and can lead to unnecessary and harmful investigations, delaying treatment The MDT is significantly less likely to request an inappropriate PET-CT than the individual clinician Collaboration among specialists may minimise the ordering of inappropriate PET-CTs, reducing costs and improving patient safety and management.
Multi-Rate Acquisition for Dead Time Reduction in Magnetic Resonance Receivers: Application to Imaging With Zero Echo Time

For magnetic resonance imaging of tissues with very short transverse relaxation times, radio-frequency excitation must be immediately followed by data acquisition with fast spatial encoding. In zero-echo-time (ZTE) imaging, excitation is performed while the readout gradient is already on, causing data loss due to an initial dead time. One major dead time contribution is the settling time of the filters involved in signal down-conversion. In this paper, a multi-rate acquisition scheme is proposed to minimize dead time due to filtering. Short filters and high output bandwidth are used initially to minimize settling time. With increasing time since the signal onset, longer filters with better frequency selectivity enable stronger signal decimation. In this way, significant dead time reduction is accomplished at only a slight increase in the overall amount of output data. Multi-rate acquisition was implemented with a two-stage filter cascade in a digital receiver based on a field-programmable gate array. In ZTE imaging in a phantom and in vivo, dead time reduction by multi-rate acquisition is shown to improve image quality and expand the feasible bandwidth while increasing the amount of data collected by only a few percent.
Differences in the relative distribution of human gene diversity between electrophoretic and red and white cell antigen loci.

Gene frequency data for 25 loci (2 HLA loci, 9 blood group loci, and 14 electrophoretically detectable loci) were collected from the literature of 18 human populations from all over the world. The data were subjected to a hierarchical gene diversity analysis to provide an estimate of the relative distribution of genetic variation between and within populations and population groups for different types of loci. Two different ways of grouping the populations, i.e., according to anthropological criteria and to a cluster analysis based on gene frequency data, gave essentially the same results. For all loci combined approximately 86% of total gene diversity was found within populations, 3% was associated with differences between populations within groups, and 11% related to group differences. These results are very similar to those obtained in previous studies based on fewer loci and different sets of populations. The distribution of genetic variation is different for different types of loci. The HLA loci give a picture very similar to that of the electrophoretic loci while the blood group loci have a substantially larger fraction of the total gene diversity distributed between populations or population groups.