Miracle-dz/UniFAR-FTUs huggingface dataset:
Interactions of the DASH Diet with the Renin-Angiotensin-Aldosterone System

ABSTRACT Background The Dietary Approaches to Stop Hypertension (DASH) diet is widely recommended to lower blood pressure, but its mechanisms of action are unclear. Lines of evidence suggest an interaction with the renin-angiotensin-aldosterone system (RAAS). Objective We conducted a randomized, controlled, cross-over feeding trial to test RAAS-related mechanisms underlying the DASH diet in patients with isolated systolic hypertension. Methods Participants entered a 1-wk run-in period on a control (CON) diet and then consumed the DASH or CON diets for 4 wk each in randomized sequence. Calorie content was controlled to maintain weight, and sodium intake was set at 3 g daily. After each diet, participants had hormonal and hemodynamic assessments obtained at baseline, in response to RAAS inhibition with captopril (CAP) 25 mg, and to graded angiotensin II (AngII) infusions (1 ng/kg and 3 ng/kg × 45 min). Primary outcomes were mean arterial pressure (MAP) and renal blood flow (RBF), and secondary outcomes were diastolic function, pulse wave velocity (PWV), plasma renin activity (PRA), and aldosterone (ALDO) responses by diet. Results In total, 44 (19 female) participants completed the study. DASH + CAP significantly lowered MAP compared with CON + CAP (83 ± 11 mmHg compared with 88 ± 14 mmHg, P <0.01). RBF was increased with DASH + CAP compared with CON + CAP (486 ± 149 cc/min compared with 451 ± 171 cc/min, P <0.001). Study diet did not change PWV but CAP reduced diastolic function on the DASH diet (P <0.05). DASH + CAP significantly increased PRA compared with CON + CAP (1.52 ± 1.78 ng/mL/min compared with 0.89 ± 1.17 ng/mL/min; P <0.001). ALDO sensitivity to AngII infusion was greater with DASH when compared to CON (17.4 ± 7.7 ng/mL compared with 13.8 ± 6.2 ng/dL, P <0.05) as was DASH + CAP compared with CON + CAP (15.1 ± 5.3 ng/dL compared with 13.1 ± 5.9 ng/mL, P <0.05). Conclusions The DASH diet interacts with the RAAS resulting in vascular and hormonal responses similar to a natriuretic effect, which appears to augment the hypotensive effect of angiotensin-converting enzyme (ACE) inhibition in individuals with isolated systolic hypertension. This trial was registered at clinicaltrials.gov as NCT00123006.
PENGARUH KETERLIBATAN SUAMI DALAM PENYULUHAN TERHADAP PENGETAHUAN DAN MINAT PENGGUNAAN ALAT KONTRASEPSI MODERN PADA UNMET NEED DI KAMPUNG KB DI KOTA YOGYAKARTA

Latar Belakang: Kampung KB adalah program sebagai upaya mewujudkan keluarga yang berkualitas. Diantara seluruh kabupaten dan kota di DIY hanya Kota Yogyakarta yang mengalami peningkatan unmet need sebelum dan sesudah pencanangan kampung KB, angka unmet need sebelum pencanangan yaitu 23,17%, kemudian angka unmet need setelah pencanangan yaitu 37,5%. Berbagai cara dapat dilakukan untuk meningkatkan penggunaan alat kontrasepsi salah satunya dengan melibatkan suami dalam penyuluhan. Tujuan Penelitian: Mengetahui pengaruh keterlibatan suami dalam penyuluhan terhadap pengetahuan dan minat penggunaan alat kontrasepsi modern pada unmet need di kampung KB di Kota Yogyakarta. Metode Penelitian: Penelitian ini adalah penelitian eksperimen dengan menggunakan rancangan pre test and post test with control group yang dilaksanakan pada bulan Juli 2018. Sampel penelitian ini adalah seluruh unmet need sesuai kriteria inklusi dan eksklusi. Dengan jumlah sampel 44 orang. Analisis data menggunakan Paired t-test, Independent t-test, dan Chi Square. Alat ukur yang digunakan adalah kuesioner. Hasil Penelitian: Terdapat peningkatan pengetahuan antara dua kelompok dengan p-value=0,0001, terdapat perbedaan minat penggunaan alat kontrasepsi antara dua kelompok dengan p-value=0,0001. Kesimpulan: Ada pengaruh keterlibatan suami dalam penyuluhan terhadap pengetahuan dan minat penggunaan alat kontrasepsi modern pada unmet need di kampung KB di Kota Yogyakarta.
Age-Specific Serum Total and Free Estradiol Concentrations in Healthy Men in US Nationally Representative Samples

Abstract Purpose To report age-specific serum estradiol concentration in nonsmoking, lean US men without comorbidities. We provide concentrations from 30 and 15 to 20 years ago given previously described declines in serum estradiol in US men over time. Methods We used data from the Third National Health and Nutrition Examination Survey (NHANES III; 1988 to 1991) and continuous NHANES (1999 to 2004). Serum estradiol and SHBG were previously measured by competitive electrochemiluminescence immunoassays. Free estradiol was estimated from estradiol, SHBG, and albumin. By age, we calculated median concentrations overall and for nonsmoking, lean (body mass index <25 kg/m2 and waist <102 cm) men without diabetes, cardiovascular disease, or cancer. Results Overall, respective total estradiol medians for men ages 20 to 39, 40 to 59, and ≥60 years old were 37.0, 33.9, and 33.5 pg/mL in NHANES III and 31.3, 30.5, and 27.0 pg/mL in continuous NHANES. In nonsmoking, lean men without comorbidities, respective total estradiol medians were 32.0, 32.1, and 32.0 pg/mL in NHANES III and 29.1, 22.7, and 26.1 pg/mL in continuous NHANES. Overall, respective free estradiol medians were 0.82, 0.72, and 0.64 pg/mL in NHANES III and 0.67, 0.61, and 0.47 pg/mL in continuous NHANES. In nonsmoking, lean men without comorbidities, respective free estradiol medians were 0.64, 0.67, and 0.62 pg/mL in NHANES III and 0.58, 0.42, and 0.40 pg/mL continuous NHANES. Conclusion We report US nationally representative serum estradiol concentrations in healthy men, which could be used for targeting estradiol during testosterone supplementation and for general good health.
Modeling the Effects of Supercomplex Formation and Stress Response on Alzheimer’S Disease Progression

Alzheimer’s disease is a specific form of dementia characterized by the aggregation of Amyloid-β plaques and tau tangles. New research has found that the formation of these aggregates occurs after dysregulation of respiratory activity and the production of radical oxygen species. Proteomic data shows that these changes are also related to unique gene expression patterns. We investigate the impact of these findings on new therapeutic options via metabolic flux analysis of sirtuin stress response pathways and respiratory supercomplex formation. Our results indicate CRISPR Cas-based gene therapy focused on upregulating stable CIII expression, and protective changes in SIRT1 and AMPK expression are potential avenues for therapeutics. This work also highlights the importance of metabolic enzyme activity in maintaining proper respiratory activity.
Do mental health disorders matter in pre- adolescents with cerebral palsy?

Objective: To assess the rate of mental health disorders according to diagnostic criteria, in pre-adolescents with Cerebral Palsy (CP). Design: Participants in this cohort study were 47 children with a diagnosis of CP, assessed at 11 years of age. They were born 2001-2003 and living in the Western Health Region of Norway. The Kiddie-SADS, a child psychiatric, diagnostic instrument, was used for assessment of mental health disorders. Results: Almost four in five children met diagnostic criteria for one or more mental health disorders. Of these children, two in three met criteria for behavioural disorder, one in three met criteria for anxiety disorder, and there was a considerable co-occurrence of disorders. No significant association was found between medical parameters and mental health disorders. Conclusions: Mental health disorders are highly prevalent in pre-adolescents with CP in the present study, and we suggest that mental health assessment should be included as part of the regular follow-up of children with CP. Correspondence to: Hanne Marit Bjorgaas, Department of Child Habilitation and Neurology, Stavanger University Hospital, Stavanger HF, Post box 8100, 4068 Stavanger, Norway, Tel: 47-98895956; E-mail: bjhm@sus.no
The Probabilistic Foundations of Rational Learning

of idealizing it is to sharp results, and sharp it is difﬁcult to have a focused discussion of the problems asso-ciated with rational learning. This is to deny that idealizations require critical scrutiny; they certainly do, but scrutiny has to come from a plausible point of view. One point of view from which to examine idealizations in models of rational learning will come up repeatedly in our discussion of updating procedures. Rational models express an ideal according to a set of evaluative standards. In practice, an might be difﬁcult to attain. this by itself does not speak against the evaluative standards. A rational a of standards in its pure form, this in real learning processes if
Peripheral blood CD4+ T cell populations by CD25 and Foxp3 expression as a potential biomarker: reflecting inflammatory activity in chronic obstructive pulmonary disease

Background The temporally dynamic changes of CD25 and Foxp3 expression in CD4+ T cells are initiated by T cell receptor (TCR) signals strength or frequency. There is a deficiency of peripheral markers for assessing COPD activity, and the current study was conducted to explore whether peripheral CD4+ T cell populations based on CD25 and Foxp3 expression could serve as an indicator for COPD inflammatory activity. Methods The distribution and phenotypic characteristics of CD4+CD25±Foxp3± T cells from peripheral blood in different populations were determined by flow cytometry. The model for the differentiation of CD4+ T cells populations by CD25 and Foxp3 expression was explored in vitro. Results The frequencies of peripheral CD4+CD25+Foxp3− T cells and CD4+CD25+Foxp3+ T cells were increased in AECOPD patients, whereas the frequency of CD4+CD25−Foxp3+ T cells was increased in SCOPD patients without receiving systemic treatment. Phenotypic analysis revealed that CD4+CD25+Foxp3− T cells, CD4+CD25+Foxp3+ T cells and CD4+CD25−Foxp3+ T cells had received antigenic stimulation and resembled central memory or effector memory T cells. The differentiation of CD4+ T cells populations by CD25 and Foxp3 expression was dictated by TCR signals. The paired study indicated that the frequencies of CD4+CD25+Foxp3− T cells, CD4+CD25+Foxp3+ T cells and CD4+CD25− Foxp3+ T cells were decreased while the frequency of CD4+CD25−Foxp3− T cells were increased in the same patients from AECOPD to convalescence. Conclusions Collectively, we propose that the dynamic changes of CD4+ T cell populations by CD25 and Foxp3 expression could function as potential biomarkers for reflecting inflammatory activity in COPD.
DETERMINATION OF CHROMATOGRAPHIC PROTONATION CONSTANTS OF SOME IMIDAZOLE ANTIMYCOTIC DRUGS IN ACETONITRILE-WATER BINARY MIXTURES

Objective: In this study, the thermodynamic protonation constant ( 𝑝𝐾 𝑎 𝑠𝑠 ) of antifungal azole derivative miconazole and tioconazole were investigated by the reversed-phase liquid chromatography (RPLC) method. Although classical stationary phases are the most commonly used column-packed materials in the analyses of these compounds by the RPLC method, the determination of the pK a value of miconazole and tioconazole with a cyano-based column has not been reported so far. Material and Method: Chromatographic behavior of the selected compounds was determined with Ultra Cyano column (Restek ® , 150×3.0 mm I.D, 3µm) which is compatible with hydrophobic compounds. The dependence of the retention times on the acetonitrile content of the mobile phase and the effect of the mobile phase pH on the chromatographic retention was determined for each compound by changing the pH in the range of 3.0-7.50. Result and Discussion: The 𝑝𝐾 𝑎 𝑠𝑠 values were determined by a nonlinear regression program. The thermodynamic aqueous pK a ( 𝑝𝐾 𝑎 𝑤𝑤 ) value of the studied compounds was calculated from the 𝑝𝐾 𝑎 𝑠𝑠 value by using the macroscopic parameters (dielectric constant and mole fraction) that play an important role in the solvent properties. The calculated 𝑝𝐾 𝑎 𝑤𝑤 values were compared with literature values.
Effects of Moringa (Moringa oleifera) leaf extract on alveolar diameter of breastfeeding and weight of infant Wistar rats

Birthweight is the quality of maternal nutrition during pregnancy. In 2005, more than 20 million infants in the world (15.5% of all births) experienced low birth weight. Efforts to improve the survival of infants. Moringa oleifera leaf extract is a medicinal plant that plays roles to increase mother’s milk production. Determine the effect of Moringa leaf extracts supplementation to mamma alveolar diameter of breastfeeding maternal and weight of infant Wistar rat. This was a Completely Randomized Design, conducted in October-March 2018. The sample used were 24 pregnant rats, negative control (KN) given aquadest, positive control (KP+) Moloco 0.13 mg/g BW/day, treatment group I (KPI) dose 0,042 mole leaf extract and treatment group II (KPII) dose 0,168 mg/g BW/day. Data were analysed using ANOVA test 5% significance and continued by post hoc LSD (Least Significant Difference) test on SPSS program version 16. The results showed that in KPII, it was found that the increase of breast alveolar diameter and infants birth weight was higher than the other treatment groups. Infants weight gain is no difference between groups. Moringa leaf extracts to 14 effective periods of pregnancy to increase the size of an alveolar diameter of breast gland and birthweight in infants.
Subprime Loan Quality ECONOMIC RESEARCH

This paper is an exploration of subprime mortgages over the cohorts from 2000 through 2006, especially those prior to 2004. In particular, this study contrasts subprime originations during the (cid:147)boom years(cid:148) of 2004-2006 with originations during an (cid:147)early period(cid:148) of 2000-2002. We develop a counterfactual technique to determine how originations during the early period would perform in a di⁄erent environment, namely, the environment faced by originations in 2004, 2005, and 2006. We (cid:133)nd that representative originations during the early period of 2000-2002 would not have performed signi(cid:133)cantly better than representative originations in 2004, 2005, and 2006. This result is robust to counterfactual exercises for originations with di⁄erent LTVs. We conclude that mortgages of early cohorts were no less vulnerable to the environment faced by cohorts of 2004-2006.
Prevalencia de ojo seco en pacientes que acuden a la Clínica de Optometría de la FESI, UNAM

espanolObjetivo: estimar la prevalencia de ojo seco y determinar si existen diferencias entre pacientesjovenes y adultos que acuden a la Clinica de Optometria de la Facultad de EstudiosSuperiores Iztacala, UNAM. Materiales y metodos: se seleccionaron 1957 pacientes de 15a 65 anos de edad evaluados en el Centro de Diagnostico de Alteraciones de la SuperficieOcular de la Facultad de Estudios Superiores Iztacala de la Universidad NacionalAutonoma de Mexico, de agosto del 2016 a agosto del 2017. Los pacientes resolvieron elcuestionario de diagnostico en su version digital OSDI y se les evaluo el patron de arborizacionde mucinas mediante Test Lagrimal de Ferning (TFT). Resultados: la prevalenciadel diagnostico tiene una diferencia significativa de P EnglishObjetive: To report the prevalence of dry eye and to determine the differences between young and adult patients attending the Optometry Clinic of the Iztacala School of Higher Education at Universidad Nacional Autonoma de Mexico (UNAM). Material and methods: In 1957, patients between the ages of 15 and 65 assessed at the “Centro de Diagnostico de Alteraciones deSuperficie Ocular” of the Iztacala School of Higher Education of UNAM between August 2016and August 2017. The patients answered the digital version of the Ocular Surface Disease Index(OSDI) diagnostic questionnaire and the mucin arborization pattern was evaluated using the TearFerning Test (TFT). Results: The mean prevalence of the diagnosis with a significant differenceof positive P
Overexpression of KRT17 promotes proliferation and invasion of non-small cell lung cancer and indicates poor prognosis

Purpose Keratin 17 (KRT17) is a 48 KDa type I intermediate filament, which is mainly expressed in epithelial basal cells. KRT17 has been shown to be overexpressed in many malignant tumors and play an important role in the occurrence and development of tumors. Therefore, this study explored the role and underlying mechanism of KRT17 in non-small cell lung cancers (NSCLC). Methods KRT17 expression and its correlations with clinicopathological factors were examined in lung cancer tissues by immunohistochemistry. The prognosis value of KRT17 in NSCLCs was retrieved from The Cancer Genome Atlas (TCGA) online databases. The expression level of KRT17 was increased or decreased by KRT17 gene transfection or small RNA interference in lung cancer cells, respectively. Further, proliferation and invasiveness of lung cancer cells were determined by cell proliferation and invasion assays, respectively. Finally, expression levels of proteins related to Wnt signaling pathways and epithelial mesenchymal transition (EMT) were detected by Western blot. Results The expression level of KRT17 in NSCLCs was significantly higher than normal lung tissues. High expression of KRT17 predicted poor prognosis of patients with NSCLCs, especially lung adenocarcinomas, and was correlated with poor differentiation and lymphatic metastasis. Overexpression of KRT17 enhanced, while KRT17 knockdown inhibited, the proliferation and invasiveness of lung cancer cells. Overexpression of KRT17 up-regulated β-catenin activity and levels of Wnt target genes, such as cyclin D1, c-Myc, and MMP7. Moreover, KRT17 promoted EMT by up-regulating Vimentin, MMP-9, and Snail expression and down-regulating E-cadherin expression. Conclusion Overexpression of KRT17 is common in NSCLCs and indicates poor prognosis. Overexpression of KRT17 enhances the proliferation and invasiveness of NSCLC cells by activating the Wnt signaling pathway and EMT process. KRT17 is a potential indicator of NSCLC progression and poor survival.
Risk analysis and prioritization of irregular order arrivals

Şirketin surekliligini saglayacak fonksiyonlarin basinda uretim gelir. Bu yuzden duzensiz siparisler sirketler tarafindan buyuk bir sorun olarak karsilanmaktadir. Bu calismada duzensiz siparislerin gelis sebepleri tespit edilmis ve bu sebepler icin risk analiz yontemlerinden Hata Turu Ve Etkileri Analizi (HTEA), ardindan oncelik sirasini belirlemek adina Analitik Hiyerarsi Prosesi (AHP) yontemi uygulanmistir. Calisma sonucunda isletmede risk onceligi olan hata/faktor turu tespit edilmistir ve onleyici faaliyetlerde bulunulmustur. Ayni risk skoruna sahip olan parametreler arasinda yapilan ikili karsilamalarda Pazar hareketlerinin, musteri tatmininin ve atolye tipi uretimlerin siparis duzensizliklerine neden oldugu gozlemlenmistir.
Energy Saving Algorithm of Zigbee Network based on Whole Network Dormancy

Wireless sensor nodes are usually powered by batteries and then work for a long time after deployment, which means that the energy of nodes could become a bottleneck of network operation. To solve the problem of energy limitation of nodes in wireless sensor network, this paper proposes an energy saving routing algorithm based on whole network dormancy. The algorithm can turn all nodes, including terminal nodes, routing nodes and sink nodes, to sleep, saving energy for each node in the network. At the same time, it designs two sleep strategies, named long sleep and short sleep strategy, for routing nodes. The two strategies can further reduce consumption under the premise of not affecting energy consumption. The experimental results based on CC2630 show that: compared with exiting related algorithm, the new algorithm reduces consumption of nodes by 10%.
Mastering Hadoop

Go beyond the basics and master the next generation of Hadoop data processing platforms About This BookLearn how to optimize Hadoop MapReduce, Pig and HiveDive into YARN and learn how it can integrate Storm with HadoopUnderstand how Hadoop can be deployed on the cloud and gain insights into analytics with HadoopWho This Book Is ForDo you want to broaden your Hadoop skill set and take your knowledge to the next level? Do you wish to enhance your knowledge of Hadoop to solve challenging data processing problems? Are your Hadoop jobs, Pig scripts, or Hive queries not working as fast as you intend? Are you looking to understand the benefits of upgrading Hadoop? If the answer is yes to any of these, this book is for you. It assumes novice-level familiarity with Hadoop. In Detail Hadoop is synonymous with Big Data processing. Its simple programming model, "code once and deploy at any scale" paradigm, and an ever-growing ecosystem makes Hadoop an all-encompassing platform for programmers with different levels of expertise.This book explores the industry guidelines to optimize MapReduce jobs and higher-level abstractions such as Pig and Hive in Hadoop 2.0. Then, it dives deep into Hadoop 2.0 specific features such as YARN and HDFS Federation.This book is a step-by-step guide that focuses on advanced Hadoop concepts and aims to take your Hadoop knowledge and skill set to the next level. The data processing flow dictates the order of the concepts in each chapter, and each chapter is illustrated with code fragments or schematic diagrams.
A lexical phononology study of Modern Standard Arabic (MSA)

This is a descriptive study of the phonology and morphology of Modern Standard Arabic (MSA) spoken in Cairo, Egypt. The study, conducted within the framework of the Lexical Phonology (LP) theory, aims at examining and describing in detail the nature of the relationship between the phonology and morphology of the MSA lexicon with a view to determine what role morphological and phonological rules play in the word formation processes and organization of the MSA lexicon. In view of the arguments presented by proponents of the LP theory with re pect to the supposedly universal phonological and morphological principles of languag , this study sets out to investigate and determine, the extent to which the e uni ersal principles are applicable in MSA. The study is guided by our research problem, which is to investigate the nature of the relationship between phonology and morphology in the organization of the MSA lexicon. It seeks to achieve se eral objecti es· key among them being to conduct a descriptive anal sis of th phonology and morphology of Modem Standard Arabic (MSA) using the parameters of the Lexical Phonology (LP) framework. To be able to answer the specific research questions raised in the study e obtained data b recording a series of conversations in various settings while J ~ focusing on specific issues and concerns that had a bearing on the objecti es ofth
Postoperative metastasis prediction based on portal vein circulating tumor cells detected by flow cytometry in periampullary or pancreatic cancer

Purpose The aim of this study was to evaluate the value of flow cytometry (FCM) detection of portal vein circulating tumor cells (CTCs) in predicting postoperative metastasis. Methods Samples of portal venous blood and peripheral blood were collected from 39 patients during surgery, and CTCs were detected by FCM, with confirmation by laser confocal microscopy and single-cell sequencing. Results Among all patients, a portal EpCAM+CD45- percentage ≥24.5×10−4 (P=0.06), peripheral EpCAM+CD45- count ≥97/5 mL (P=0.034), peripheral EpCAM+CD45- percentage ≥4.4×10−4 (P=0.042), and CA242≥3.5 U/mL (P=0.027) were significant predictors of metastasis. Further analysis showed that the portal EpCAM+CD45- ratio ≥24.5×10−4 is a predictor of metastasis (P=0.025) in pancreatic cancer after curative resection. Conclusion CTCs detected by FCM in portal venous blood are of significant value for the prediction of postoperative metastasis in pancreatic or periampullary tumors.