Miracle-dz/UniFAR-FTUs huggingface dataset:
language differential gene regulation in the human immune system.

Adverse social conditions have been linked to a conserved tran- scriptional response to adversity (CTRA) in circulating leukocytes that may contribute to social gradients in disease. However, the CNS mechanisms involved remain obscure, in part because CTRA gene-expression profiles often track external social – environmental variables more closely than they do self-reported internal affective states such as stress, depression, or anxiety. This study examined the possibility that variations in patterns of natural language use might provide more sensitive indicators of the automatic threat-detection and -response systems that proximally regulate auto- nomic induction of the CTRA. In 22,627 audio samples of natural speech sampled from the daily interactions of 143 healthy adults, both total language output and patterns of function-word use covaried with CTRA gene expression. These language features pre- dicted CTRA gene expression substantially better than did conventional self-report measures of stress, depression, and anxiety and did so independently of demographic and behavioral factors (age, sex, race, smoking, body mass index) and leukocyte subset distribu- tions. This predictive relationship held when language and gene expression were sampled more than a week apart, suggesting that associations reflect stable individual differences or chronic life circumstances. Given the observed relationship between personal ex- pression and gene expression, patterns of natural language use may provide a useful behavioral indicator of nonconsciously evaluated well-being (implicit safety vs. threat) that is distinct from conscious affective experience and more closely tracks the neurobiological processes involved in peripheral gene regulation.
The concordance correlation coefficient estimated through variance components

We demonstrate that concordance correlation coefficient (CCC) and the intraclass correlation coefficient are the same measure of agreement estimated in two ways: variance components and moment method procedures. The variance components approach allows the CCC to be easily extended to more than two observers and to be adjusted using confounding covariates by incorporating them in the mixed model
Towards conceptualizing reverse service supply chains 1

Research limitations/implications – The findings of this research can help future researchers to analyse, map and model forward and reverse service supply chains, and to identify potential research gaps in the area. Practical implications – The findings of the research can help managers of service firms to gain better visibility of their forward and reverse supply chains, and refine their business models to help extend their reverse/closed–loop activities. Furthermore, the findings can help managers to better optimize their service operations to reduce service gaps and potentially secure new value-adding opportunities. Originality/value – This paper is the first, to our knowledge, to conceptualize the basic structure of the forward and reverse service supply chains while dealing with the high level of heterogeneity of services.
COPD_A_289099 817..824

1Department of Pulmonology, Albert Schweitzer Hospital, Dordrecht, the Netherlands; 2Department of Intensive Care, Albert Schweitzer Hospital, Dordrecht, the Netherlands; 3Department of Biostatics, Erasmus University Medical Centre, Rotterdam, the Netherlands Background: The effectiveness of non-invasive home ventilation in patients with severe chronic obstructive pulmonary disease (COPD) is lacking. Non-invasive home ventilation might be more effective when high ventilator settings are used. However, high ventilator settings might reduce patient adherence. We have developed a multidisciplinary approach (ventilation practitioners, 24 hours support of respiratory nurses, physicians) to non-invasive ventilation aimed at optimizing patient adherence using low ventilator settings in severe COPD patients with high disease burden irrespectively having hypercapnia. Methods: We included in a proof of concept, prospective interventional study, 48 GOLD stage III–IV COPD patients with a high disease burden (≥2 exacerbations in a year, and Medical Research Council dyspnea scores ≥3). Outcome measures included hospital admissions, capillary pCO2, Medical Research Council dyspnea scores (MRC), Clinical COPD Questionnaire scores (CCQ) and Hospital Anxiety and Depression Scale (HADS). Results: After 1 year 32 patients could be evaluated. Hospital admissions decreased by 1.0 admission (mean difference ± SD: 1.0 ± 1.48; p = 0.001). In-hospital days decreased by 10.0 days (10.0 ± 15.48; p = 0.001). Capillary pCO2 decreased by 0.33 kPa (0.33 ± 0.81: p = 0.03). The MRC dyspnea score decreased by 0.66 (0.66 ± 1.35; p = 0.02). The CCQ score decreased by 0.59 (0.59 ± 1.39; p = 0.03). The HADS anxiety score decreased by 1.64 (1.64 ± 3.12; p = 0.01). The HADS depression score decreased by 1.64 (1.64 ± 3.91; p = 0.04). Conclusion: A proof of concept multidisciplinary approach, using low pressure domiciliary non-invasive ventilation, aimed at optimizing patient adherence in severe COPD patients regardless having hypercapnia, reduced hospital admissions and improved symptoms and quality of life measures. This may imply that severe COPD patients with high disease burden, irrespective being hypercapnic, are candidates to be treated with low pressure domiciliary non-invasive ventilation.
Interaction in Spoken Word Recognition Models: Feedback Helps

Human perception, cognition, and action requires fast integration of bottom-up signals with top-down knowledge and context. A key theoretical perspective in cognitive science is the interactive activation hypothesis: forward and backward flow in bidirectionally connected neural networks allows humans and other biological systems to approximate optimal integration of bottom-up and top-down information under real-world constraints. An alternative view is that online feedback is neither necessary nor helpful; purely feed forward alternatives can be constructed for any feedback system, and online feedback could not improve processing and would preclude veridical perception. In the domain of spoken word recognition, the latter view was apparently supported by simulations using the interactive activation model, TRACE, with and without feedback: as many words were recognized more quickly without feedback as were recognized faster with feedback, However, these simulations used only a small set of words and did not address a primary motivation for interaction: making a model robust in noise. We conducted simulations using hundreds of words, and found that the majority were recognized more quickly with feedback than without. More importantly, as we added noise to inputs, accuracy and recognition times were better with feedback than without. We follow these simulations with a critical review of recent arguments that online feedback in interactive activation models like TRACE is distinct from other potentially helpful forms of feedback. We conclude that in addition to providing the benefits demonstrated in our simulations, online feedback provides a plausible means of implementing putatively distinct forms of feedback, supporting the interactive activation hypothesis.
CMAR_A_313078 5013..5026

1The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, 510000, People’s Republic of China; 2Department of Integrated Traditional Chinese & Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People’s Republic of China; 3Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510000, People’s Republic of China Background: Stomach adenocarcinoma (STAD) is the most common gastrointestinal cancer and is associated with high mortality worldwide. Endothelin receptor type A (EDNRA) is associated with guanine-nucleotide-binding (G) proteins and plays important roles in cellular processes and various diseases. Purpose: To investigate the prognosis value of EDNRA expression and its correlation with immune infiltrates in patients with STAD. Methods: The association between clinical characteristics and EDNRA expression in STAD was analyzed using the Wilcoxon signed-rank test and logistic regression. The Kaplan–Meier plotter analysis and Cox regression were constructed to evaluate the influence of EDNRA on prognosis, and a receiver operating characteristic (ROC) curve and nomogram were constructed. Gene set enrichment analysis (GSEA) and single-sample gene set enrichment analysis (ssGSEA) were conducted to analyze the correlation between EDNRA and immune infiltrates. In addition, Oncomine, TIMER databases and qRT-PCR of STAD cell lines were used to verify the EDNRA expression in STAD. Results: Our results revealed that EDNRA expression was significantly higher in patients with STAD than normal gastric tissues, and the results have been confirmed by RT-qPCR. KM-plotter analysis revealed that patients with STAD had shorter OS, FP, and PPS (P<0.001). Multivariate Cox analysis further confirmed that high EDNRA expression was an independent risk factor for OS in patients with STAD. Moreover, other clinicopathologic features were related with worse prognosis in STAD, including age, lymph nodes metastases and primary outcome. More importantly, ROC analysis also confirmed the diagnostic value, and a prognostic nomogram involving age, T, M, N classification, pathologic stage, residual tumor and EDNRA was constructed. GSEA revealed that high EDNRA expression was correlated with immunoregulatory interactions between lymphoid and non lymphoid cells pathways, natural killer cell activation involved in immune response, interleukin 1 receptor binding and pathways in cancer, and ssGSEA showed that EDNRA is correlated with macrophages and NK cells. Conclusion: Collectively, EDNRA can be an independent prognostic biomarker and correlated with immune infiltration in stomach adenocarcinoma.
OTT_A_243823 4319..4337

1The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 2Department of Gastrointestinal Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi 530021, People’s Republic of China; 3Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 4Department of Research, Guangxi Medical University Cancer Hospital, Nanning, Guangxi 530021, People’s Republic of China; 5Guangxi Colleges and Universities Key Laboratory of Biological Molecular Medicine Research, Nanning, Guangxi, People’s Republic of China; 6Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi, Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning, Guangxi, People’s Republic of China
Development of microsatellite markers for the mycoheterotrophic species Burmannia nepalensis (Miers) Hook.f. based on RAD sequencing

Mycoheterotrophs represent a fascinating group of plants. They derive carbon from mycorrhizal fungi, which often simultaneously have a mutualistic interac-tion with surrounding photosynthetic plants and are thus often referred to as cheaters or exploiters (Bidartondo, 2005; Merckx et al., 2009). The structures of the flower, Mycoheterotrophic plants can derive carbon from fungi rather than from pho-tosynthesis. Habitat destruction and sensitivity to environmental perturba-tion may result in the loss of biodiversity including genetic variation of mycoheterotrophic plants. Burmannia nepalensis (Miers) Hook.f. (Burmanniaceae) is a mycoheterotrophic plant with a wide distribution across southern China and southern and eastern Asia. As part of our endeavor to reveal population genetic patterns of mycoheterotrophic plants, fifteen microsatellite loci were developed by RAD (restriction site-associated DNA) sequencing in 89 individuals from four populations of B. nepalensis . A total of 49 alleles were amplified. The number of alleles per locus ranged from two to six with an average of 3.3. The observed and expected heterozygosity per population varied from 0.000 to 1.000 and from 0.000 to 0.722, respectively. A transferability test showed that only one to five loci could be cross-amplified successfully in four other congeneric species of Burmannia . These markers can be used to reveal population genetic diversity in B. nepalensis , and will help to elucidate the evolutionary history and to enhance efforts for conservation of mycoheterotrophic plants.
International Journal of Advanced Research in Computer Science and Software Engineering

— Video compression has been the object of intensive research in the last thirty years. The field is now mature as is proven by the large number of applications that make use of this technology. Currently, both VCEG and MPEG are launching their next-generation video coding standards. This paper proposes a new HEVC standard tool technique in compressing video as well as provide the subsequent techniques like joint prediction techniques along with skip, motion compensation, adaptive prediction, inter or intra modes, are also presented. HEVC is also known as ISO/IEC 23008-2 MPEG-H Part 2 and ITU-T H.265. HEVC has achieved enormous compression performance improvement. Finally, it is designed to provide high compression efficiency and better video quality.
G LOBAL C ONCAVITY AND O PTIMIZATION IN A C LASS OF D YNAMIC D ISCRETE C HOICE M ODELS

Discrete choice models with unobserved heterogeneity are commonly used Econometric models for dynamic Economic behavior which have been adopted in practice to predict behavior of individuals and ﬁrms from schooling and job choices to strategic decisions in market competition. These models feature optimizing agents who choose among a ﬁnite set of options in a sequence of periods and receive choice-speciﬁc payoffs that depend on both variables that are observed by the agent and recorded in the data and variables that are only observed by the agent but not recorded in the data. Existing work in Econometrics assumes that optimizing agents are fully rational and requires ﬁnding a functional ﬁxed point to ﬁnd the optimal policy. We show that in an important class of discrete choice models the value function is globally concave in the policy. That means that simple algorithms that do not require ﬁxed point computation, such as the policy gradient algorithm, globally converge to the optimal policy. This ﬁnding can both be used to relax behavioral assumption regarding the optimizing agents and to facilitate Econometric analysis of dynamic behavior. In particular, we demonstrate signiﬁcant computational advantages in using a simple implementation policy gradient algorithm over existing “nested ﬁxed point” algorithms used in Econometrics.
Acousto-optic method for liquids refractometry

Various methods of liquids refractive index measurements were previously developed by others. They differ however in the measurement accuracy, the used light wavelength, the measurement range and the sensitivity to the temperature and pressure. In this work, we present and discuss an acousto-optic technique for measuring the index of refraction of transparent liquid materials. In the proposed technique, a diffraction pattern produced by an acousto-optic interaction is imaged by a liquid lens placed between an optical flat glass and a convergent glass lens. The diffraction pattern consists of two symmetrical dots that are digitized by a CCD camera. The focal shift, which is induced by the liquid sample, produces changes in the position of the diffracted orders. The spatial frequency measurement of the diffractive pattern leads to determine the sample refractive index. The current method presents the advantage to have an adjustable measurement range and can be easily interpreted geometrically.
NETCDL: The Network Certification Description Language

A BSTRACT Modern IP networks are complex entities that require constant maintenance and care. Similarly, constructing a new network comes with a high amount of upfront cost, planning, and risk. Unlike the disciplines of software and hardware engineering, networking and IT professionals lack an expressive and useful certification language that they can use to verify that their work is correct. When installing and maintaining networks without a standard for describing their behavior, teams find themselves prone to making configuration mistakes. These mistakes can have real monetary and operational efficiency costs for organizations that maintain large networks. In this research, the Network Certification Description Language (NETCDL) is proposed as an easily human readable and writeable language that is used to describe network components and their desired behavior. The complexity of the grammar is shown to rank in the top 5 out of 31 traditional computer language grammars, as measured by metrics suite. The language is also shown to be able to express the majority of common use cases in network troubleshooting. A workflow involving a certifier tool is proposed that uses NETCDL to verify network correctness, and a reference certifier design is presented to guide and standardize future implementations.
The clinical of continuing to prescribe antiretroviral therapy in patients with advanced AIDS who manifest no or

Introduction: Despite the efficacy and tolerability of modern antiretroviral therapy (ART), many patients with advanced AIDS prescribed these regimens do not achieve viral suppression or immune reconstitution as a result of poor adherence, drug resistance, or both. The clinical outcomes of continued ART prescription for such patients have not been well characterized. Methods: We examined the causes and predictors of all-cause mortality, AIDS-defining conditions, and serious non-AIDS- defining events among a cohort of participants in a clinical trial of pre-emptive therapy for CMV disease. We focused on participants who, despite ART had failed to achieve virologic suppression and substantive immune reconstitution. Results: 233 ART-receiving participants entered with a median baseline CD4 + T cell count of 30/mm 3 and plasma HIV RNA of 5 log 10 copies/mL. During a median 96 weeks of follow-up, 24.0% died (a mortality rate of 10.7/100 patient-years); 27.5% reported a new AIDS-defining condition, and 22.3% a new serious non-AIDS event. Of the deaths, 42.8% were due to an AIDS-defining condition, 44.6% were due to a non-AIDS-defining condition, and 12.5% were of unknown etiology. Decreased risk of mortality was associated with baseline CD4 + T cell count $ 25/mm 3 and lower baseline HIV RNA. Conclusions: Among patients with advanced AIDS prescribed modern ART who achieve neither virologic suppression nor immune reconstitution, crude mortality percentages appear to be lower than reported in cohorts of patients studied a decade earlier. Also, in contrast to the era before modern ART became available, nearly half of the deaths in our modern-era study were caused by serious non-AIDS-defining events. Even among the most advanced AIDS patients who were not obtaining apparent immunologic and virologic benefit from ART, continued prescription of these medications appears to alter the natural history of AIDS—improving survival and shifting the causes of death from AIDS- to non-AIDS-defining conditions.
Impact of BYOD on organizational commitment: an empirical investigation

PurposeBring your own device (BYOD) refers to employees utilizing their personal mobile devices to perform work tasks. Drawing on the job demands-resources (JD-R) model and the task-technology fit (TTF) model, the purpose of this paper is to develop a model that explains how BYOD affects employee well-being (through job satisfaction), job performance self-assessment, and organizational commitment through perceived job autonomy, perceived workload and TTF.Design/methodology/approachSurvey data from 400 full-time employees in different industry sectors in Mauritius were used to test a model containing 13 hypotheses using confirmatory factor analysis and structural equation modeling.FindingsThe SEM results support the hypothesized model. Findings indicate that BYOD indirectly affects job satisfaction, job performance and organizational commitment via job demands (perceived workload), job resources (perceived job autonomy) and TTF. Further, job resources influences job demands while TTF predicted job performance. Finally, job satisfaction and job performance self-assessment appear to be significant determinants of organizational commitment.Practical implicationsThe findings are congruent with the JD-R and TTF models, and confirm that BYOD has an impact on job satisfaction, job performance self-assessment and organizational commitment. This could inform organizations’ policies and practices relating to BYOD, leading to improved employee well-being, performance and higher commitment.Originality/valueThe expanded model developed in this study explains how employee well-being, performance and organizational commitment are affected by BYOD, and is one of the first studies to investigate these relationships.
University of Birmingham Structural flexibility of a conserved antigenic region in hepatitis C virus glycoprotein E2 recognized by broadly neutralizing antibodies

Neutralizing antibodies (NAbs) targeting glycoprotein E2 are important for the control of hepatitis C virus (HCV) infection. One conserved antigenic site (amino acids 412 to 423) is disordered in the reported E2 structure, but a synthetic peptide mimicking this site forms a (cid:2) -hairpin in complex with three independent NAbs. Our structure of the same peptide in complex with NAb 3/11 demonstrates a strikingly different extended conformation. We also show that residues 412 to 423 are essential for virus entry but not for E2 folding. Together with the neutralizing capacity of the 3/11 Fab fragment, this indicates an unexpected structural ﬂexibility within this epitope. NAbs 3/11 and AP33 (recognizing the extended and (cid:2) -hairpin conformations, respec-tively) display similar neutralizing activities despite converse binding kinetics. Our results suggest that HCV utilizes conformational ﬂexibility as an immune evasion strategy, contributing to the limited immunogenicity of this epitope in patients, similar to the conformational
Smooth Transition Process of Sleep Mechanism Based on SDN Framework

Green network uses sleep mechanism for energy-saving design, achieving sleep mechanism needs to consider that the mechanism may cause data loss, network performance degradation and other situations. In the traditional network, sleep mechanism requires protocol and equipment support, it is complex and low economic benefit. Due to the use of hierarchical and centralized control, software-defined network(SDN) can easily achieve a variety of network applications. The paper realizes the smooth transition process of sleep mechanism of link based on SDN framework. The results show that the design ensures the performance and normal operation of the network while realizing dormancy.
ALTERATION OF GROWTH AND FLOWERING OF Cucumis sativus L. BY APPLICATION OF SEX STEROIDS in vitro

The effect of selected sex steroids on plant morphology, flowering and sex expression in Cucumis sativus cultivar Kmicic F1 was investigated. Plants were cultured on the medium with the addition of progesterone, testosterone and estrone at concentrations of 0.1 and 1.0 µM. All tested steroids caused shortening in the main stem over the control, while the number of main stem nodes was similar to the control. Testosterone and progesterone stimulated female flower, decreasing male flower production. Plants cultured on the medium with estrone had shortest stems and the total number of flowers produced was more than four-fold lower compared to the control; however, a shift toward femaleness was observed. Application of the tested sex steroids in vitro altered flower morphology. Pollen viability in the anthers of male flowers developed on plants cultured on the media with steroids was decreased, compare to control, suggesting their effect on pollen development.