Miracle-dz/UniFAR-FTUs huggingface dataset:
Towards Zn-Dominant Tourmaline: A Case of Zn-Rich Fluor-Elbaite and Elbaite from the Julianna System at Piława Górna, Lower Silesia, SW Poland

Tourmalines are a group of minerals which may concentrate various accessory components, e.g., Cu, Ni, Zn, Bi, Ti, and Sn. The paper presents fluor-elbaite and elbaite from a dyke of the Julianna pegmatitic system at Pilawa Gorna, at the NE margin of the Bohemian Massif, SW Poland, containing up to 6.32 and 7.37 wt % ZnO, respectively. Such high amounts of ZnO are almost two times higher than in the second most Zn-enriched tourmaline known to date. The compositions of the Zn-rich tourmalines from Pilawa Gorna, studied by electron micropropy and Raman spectroscopy, correspond to the formulae: X(Na0.733Ca0.013☐0.254)Σ1Y(Al1.033Li0.792Zn0.755Fe2+0.326Mn0.094)Σ3ZAl6(TSi6O18)(BO3)3V(OH)3W(F0.654OH0.344), and X(Na0.779Ca0.015☐0.206)Σ1Y(Al1.061Li0.869Zn0.880Fe2+0.098Mn0.094)Σ3ZAl6(TSi6O18)(BO3)3V(OH)3W(OH0.837F0.163), respectively, with Zn as one of the main octahedral occupants. A comparison with other tourmalines and associated Zn-rich fluor-elbaite and elbaite from the pegmatite indicates that atypically high Zn-enrichment is not a result of Zn-Fe fractionation, but dissolution and reprecipitation induced by a late (Na,Li,B,F)-bearing fluid within the assemblage of gahnite spinel and primary schorl-type tourmaline. This strongly suggests Na-Li-B-F metasomatism of gahnite-bearing mineral assemblages as that is the only environment that can promote crystallization of a hypothetical Zn-dominant tourmaline. The compositions of the Zn-rich fluor-elbaite and elbaite suggest three possible end-members for such a hypothetical tourmaline species: NaZn3Al6(Si6O18)(BO3)3(OH)3(OH), ☐(Zn2Al)Al6(Si6O18)(BO3)3(OH)3(OH) and Na(Zn2Al)Al6(Si6O18)(BO3)3(OH)3O by analogy with other tourmalines with divalent Y occupants, such as schorl/foitite/oxy-schorl and dravite/magnesio-foitite/oxy-dravite.
A Multistate Single-Connection Calibration for Microwave Microfluidics

With emerging medical, chemical, and biological applications of microwave-microfluidic devices, many researchers desire a fast and accurate calibration that can be achieved in a single connection. However, traditional on-wafer or coaxial calibrations require measurements of several different artifacts to the data prior to measuring the microwave-microfluidic device. Ideally, a single artifact would be able to present different impedance states to correct the vector network analyzer data, minimizing drift and eliminating artifact-to-artifact connection errors. Here, we developed a multistate single-connection calibration that used a coplanar waveguide loaded with a microfluidic channel. We then used measurements of the uncorrected scattering parameters of the coplanar waveguide with the channel empty, filled with deionized water, and filled with 30 w% (30 grams per liter) of saline to construct an eight-term error model and switch-term correction. After correction, the residuals between measured scattering parameters and with the literature-based finite-element simulations were below −40 dB from 100 MHz to 110 GHz. This multistate single-connection calibration is compatible with both wafer-probed and connectorized microwave-microfluidic devices for accurate impedance spectroscopy and materials characterization without the need for multiple device measurements.
A novel determinant based transmit antenna selection technique in single user MIMO systems

Transmit antenna selection problem is addressed. Antenna selection is a technique that can be used to minimize the cost of Radio Frequency (RF) chains or to adapt of the varying nature of the channel rendering some spatial paths more significance for transmission than the others. In this paper a suboptimal greedy selection technique is proposed. The greedy selection criterion is based on maximizing the determinant of the selected sub-channel matrix. Numerical simulations show that the proposed selection algorithm approaches the performance of the optimal exhaustive search method, yet with a decreased computational burden on the user side.
Complete male mitochondrial genomes of European Mytilus edulis mussels

Abstract Doubly uniparental inheritance (DUI) results in the existence of two gender-specific, divergent mtDNA lineages within a single species. Under DUI, the female genome (F) is transmitted from mothers to the whole offspring, and the male genome (M) is transmitted exclusively from fathers to sons. This system was first described in a marine mussels Mytilus edulis inhabiting European coastal waters, over a decade ago. Despite that, the complete sequence of the M genome from the European M. edulis mussels remained unknown. Here we announce it for the first time. The announcement is based on the two haplotypes isolated from heteroplasmic males of European M. edulis sampled at two moderately distant locations: southern North Sea and western Baltic. The two M genomes are quite similar both in length (16,631 and 16,632 bp) and in sequence (98.3%). Furthermore, both newly sequenced genomes are closely related to the genomes described from Baltic M. trossulus.
Studies on the Tissue Localization of HKDC1, a Putative Novel Fifth Hexokinase, in Humans

Hexokinase domain component 1 (HKDC1) is a recently discovered novel protein, which is being promoted as a putative fifth hexokinase. Although the exact role HKDC1 plays in physiology is still unclear, it has been shown to be important during pregnancy in the regulation of glucose homeostasis. In this study, we have comprehensively studied the expression pattern of HKDC1 in the human body. Using human tissue sample, immunohistochemistry imaging was performed. Our studies indicate that the tissues with highest HKDC1 expression were the brush border epithelium of the intestines, parts of the pancreas, and lung alveolar macrophages. Future directions will be to understand the role of this fifth hexokinase in these tissues, with a focus on its relative function as compared with other endogenously expressed hexokinases.
Pressure Induced Densification and Compression in a Reprocessed Borosilicate Glass

Pressure induced densification and compression of a reprocessed sample of borosilicate glass has been studied by X-ray radiography and energy dispersive X-ray diffraction using a Paris-Edinburgh (PE) press at a synchrotron X-ray source. The reprocessing of a commercial borosilicate glass was carried out by cyclical melting and cooling. Gold foil pressure markers were used to obtain the sample pressure by X-ray diffraction using its known equation of state, while X-ray radiography provided a direct measure of the sample volume at high pressure. The X-ray radiography method for volume measurements at high pressures was validated for a known sample of pure α-Iron to 6.3 GPa. A sample of reprocessed borosilicate glass was compressed to 11.4 GPa using the PE cell, and the flotation density of pressure recovered sample was measured to be 2.755 gm/cc, showing an increase in density of 24%, as compared to the starting sample. The initial compression of the reprocessed borosilicate glass measured by X-ray radiography resulted in a bulk modulus of 30.3 GPa in good agreement with the 32.9 GPa value derived from the known elastic constants. This method can be applied to variety of amorphous materials under high pressures.
Successful treatment of extensive splanchnic vein thrombosis in a patient with mycosis fungoides

A 33-year-old man of a Middle Eastern origin presented to us with abdominal pain and distension secondary to refractory ascites of 1-month duration. The patient had a history of taking oral retinoic acid 25 mg for 4 months for mycosis fungoides. Investigations revealed thrombosis of hepatic veins with extensive thrombosis of the porto-mesenteric axis. A combination of transjugular intrahepatic portosystemic shunt, balloon angioplasty and thrombolysis with recombinant tissue plasminogen activator was successfully used to treat his condition.
The Relationship of Internally Directed Behavior to Self-Reinforcement, Self-Esteem, and Expectancy Values for Exercise

Purpose. This study investigated two opposing orientations toward exercise and wellness behavior as related to selected personal characteristics. A “self-trusting” orientation focuses on process measures, and exercise and wellness behavior is internally directed. A “self-controlling” orientation focuses on outcome measures, and exercise and wellness behavior is externally directed. Design. Relationships among variables were assessed using Pearson correlation and step-wise multiple regression. Setting. One questionnaire was administered to all subjects under quiet classroom conditions. Subjects. Subjects were enrolled in university physical education activity classes (N = 154), a health promotion and fitness undergraduate class (N = 52), and a commercial aerobic dance program (N = 68). Measures. The questionnaire, containing 157 items, assessed exercise orientation, wellness orientation, general self-esteem, physical self-esteem, self-reinforcement, expectancy values for exercise, and level of physical activity. Results. Individuals who reported exercising to improve physical appearance and/or physical performance had higher control scores on the exercise scale; exercising for pleasure or social reasons served as suppressor variables. High control scores on wellness and exercise orientation were indicative of individuals less likely to positively self-reinforce their behavior. A high control score on the wellness scale was significantly related to lower general and physical self-esteem scores. Finally, higher physical self-esteem was significantly related to exercising for pleasure and athletic reasons; exercising to improve physical appearance served as a suppressor variable. Conclusions. These data strengthen the recommendation that health promotion professionals consider alternative approaches to promoting exercise and enhancing wellness. Programming strategies that foster internally directed exercise and wellness behaviors may be more centrally related to an individual's well-being than programs that support externally directed behavior.
Does Stroke Rehabilitation Really Matter? Part B: An Algorithm for Prescribing an Effective Intensity of Rehabilitation

Background. The proportional recovery rule suggests that current rehabilitation practices may have limited ability to influence stroke recovery. However, the appropriate intensity of rehabilitation needed to achieve recovery remains unknown. Similarities between rodent and human recovery biomarkers may allow determination of rehabilitation thresholds necessary to activate endogenous biological recovery processes. Objective. We determined the relative influence that clinically relevant biomarkers of stroke recovery exert on functional outcome. These biomarkers were then used to generate an algorithm that prescribes individualized intensities of rehabilitation necessary for recovery of function. Methods. A retrospective cohort of 593 male Sprague-Dawley rats was used to identify biomarkers that best predicted poststroke change in pellet retrieval in the Montoya staircase-reaching task using multiple linear regression. Prospective manipulation of these factors using endothelin-1-induced stroke (n = 49) was used to validate the model. Results. Rehabilitation was necessary to reliably predict recovery across the continuum of stroke severity. As infarct volume and initial impairment increased, more intensive rehabilitation was required to engage recovery. In this model, we prescribed the specific dose of daily rehabilitation required for rats to achieve significant motor recovery using the biomarkers of initial poststroke impairment and infarct volume. Conclusions. Our algorithm demonstrates an individualized approach to stroke rehabilitation, wherein imaging and functional performance measures can be used to develop an optimized rehabilitation paradigm for rats, particularly those with severe impairments. Exploring this approach in human patients could lead to an increase in the proportion of individuals experiencing recovery of lost motor function poststroke.
Semi-Automatic 2D-to-3D Conversion Using Low-Rank Matrix Recovery

Semi-automatic 2D-to-3D conversion is a promising solution to 3D stereoscopic content creation. However, the depth continuous transition between user marked neighboring regions will be lost when user scribbles are sparse. To help solve this problem, a piecewise-continuity regularized low-rank matrix recovery method is developed. Our approach is based on the fact that a depth-map can be decomposed into a low-rank matrix and an outlier term matrix. First, an initial dense depth-map is interpolated from the user scribbles using matting Laplacian scheme under the assumption that depth-map is piecewise-continuous. Second, a piecewise-continuity constrained low-rank recovery model is developed to remove outliers which are introduced by the interpolation. Experimental comparisons with existing algorithms show that our method demonstrates significant advantage over depth continuous transition between neighboring regions.
Comparative study of cyto‐ and genotoxic potential with mechanistic insights of tungsten oxide nano‐ and microparticles in lung carcinoma cells

The exigency of semiconductor and super capacitor tungsten oxide nanoparticles (WO3 NPs) is increasing in various sectors. However, limited information on their toxicity and biological interactions are available. Hence, we explored the underlying mechanisms of toxicity induced by WO3 NPs and their microparticles (MPs) using different concentrations (0–300 μg ml–1) in human lung carcinoma (A549) cells. The mean size of WO3 NPs and MPs by transmission electron microscopy was 53.84 nm and 3.88 μm, respectively. WO3 NPs induced reduction in cell viability, membrane damage and the degree of induction was size‐ and dose‐dependent. There was a significant increase in the percentage tail DNA and micronuclei formation at 200 and 300 μg ml–1 after 24 hours of exposure. The DNA damage induced by WO3 NPs could be attributed to increased oxidative stress and inflammation through reactive oxygen species generation, which correlated with the depletion of reduced glutathione content, catalase and an increase in malondialdehyde levels. Cellular uptake studies unveiled that both the particles were attached/surrounded to the cell membrane according to their size. In addition, NP inhibited the progression of the cell cycle in the G2/M phase. Other studies such as caspase‐9 and ‐3 and Annexin‐V‐fluorescein isothiocyanate revealed that NPs induced intrinsic apoptotic cell death at 200 and 300 μg ml–1 concentrations. However, in comparison to NPs, WO3 MPs did not incite any toxic effects at the tested concentrations. Under these experimental conditions, the no‐observed‐significant‐effect level of WO3 NPs was determined to be ≤200 μg ml–1 in A549 cells.
Signatures of natural selection in abiotic stress-responsive genes of Solanum chilense

Environmental conditions are strong selective forces, which may influence adaptation and speciation. The wild tomato species Solanum chilense, native to South America, is exposed to a range of abiotic stress factors. To identify signatures of natural selection and local adaptation, we analysed 16 genes involved in the abiotic stress response and compared the results to a set of reference genes in 23 populations across the entire species range. The abiotic stress-responsive genes are characterized by elevated nonsynonymous nucleotide diversity and divergence. We detected signatures of positive selection in several abiotic stress-responsive genes on both the population and species levels. Local adaptation to abiotic stresses is particularly apparent at the boundary of the species distribution in populations from coastal low-altitude and mountainous high-altitude regions.
Evidence for an association between the dopamine D3 receptor gene DRD3 and schizophrenia.

Association of the dopamine D3 receptor gene (DRD3) and schizophrenia was examined in unrelated Israeli and Italian schizophrenic patients and ethnically matched normal control subjects. In the combined sample, there was a significant excess of DRD3 allele 2 among the schizophrenic patients (chi2 = 4.70, d.f. 1, p = 0.03). Comparison of genotype frequencies revealed an excess of the 2-2 genotype in the combined schizophrenic sample (chi2 = 8.30, d.f. 1, p = 0.01) and in the non-Ashkenazi Israeli schizophrenics alone (chi2 = 5.70, d.f. 2, p = 0.05). DRD3 2-2 genotype conferred a significantly increased risk of schizophrenia (chi2 = 8.21, d.f. 1, p = 0.004; OR = 2.87, CI 95% = 1.36-5.76) in the combined sample and in the non-Ashkenazi Israeli schizophrenics (chi2 = 7.22, d.f. 1, p = 0.04; OR = 7.22, CI 95% = 1.04-24.83). In the combined and Italian samples, allele 2 was associated with early age of onset as was the 2-2 genotype in the combined sample and non-Ashkenazi group. The 2-2 genotype was associated with poor response to neuroleptics, particularly in the non-Ashkenazi, Israeli schizophrenics. The possibility that DRD3 or a locus in linkage disequilibrium with it may play a role in the transmission of schizophrenia, is considered in relation to previous positive and negative reports.
Novel Mutation of the Dystrophin Gene in a Child with Duchenne Muscular Dystrophy

ABSTRACT Introduction: Duchenne muscular dystrophy (DMD) is an X-linked autosomal recessive genetic disorder caused by mutations in DMD gene. Approximately 70% of the mutations are caused by deletions or duplications of DMD exons, while the remaining were minor mutations. Case report: We present a 5-year-old boy with typical clinical features of DMD. A novel mutation was identified as a c. 9358_9359insA of DMD gene by next-generation sequencing. This mutation which was origined from mother, generated a frameshift mutation and resulted in abnormal synthesis of protein polypeptide chains. Conclusion: We demonstrated a novel mutation of DMD gene and expanded the spectrum of mutations causing DMD.
Pancytopenia and Myelodysplastic Changes in Aceruloplasminemia: A Case with a Novel Pathogenic Variant in the Ceruloplasmin Gene

A 72-year-old Japanese woman suffered from mild pancytopenia 3 years before her initial hospitalization. On admission, the levels of trace elements, particularly copper, and ceruloplasmin were significantly decreased in her blood serum. Abdominal lymphadenopathy and bone marrow dysplasia were detected. Hemosiderin deposition was observed in her lymph nodes and bone marrow, and magnetic resonance imaging suggested its deposition in various organs. A novel missense pathogenic variant (c.T1670G) was detected in the ceruloplasmin gene, resulting in an amino acid change (p.M557R). When copper deficiency is accompanied by cytopenia and dysplasia in a patient, it is worthwhile to consider a differential diagnosis of aceruloplasminemia.
Pacific Northwest Udall Center of excellence clinical consortium: study design and baseline cohort characteristics.

BACKGROUND The substantial proportion of individuals with Parkinson's disease (PD) who have or are expected to develop concomitant cognitive impairment emphasizes the need for large, well-characterized participant cohorts to serve as a basis for research into the causes, manifestations, and potential treatments of cognitive decline in those with PD. OBJECTIVE To establish a multi-site clinical core that cognitively and clinically characterizes patients with PD by obtaining quality longitudinal clinical, neuropsychological, and validated biomarker data. METHODS Six hundred nineteen participants with idiopathic PD (68.0 ± 9.1 years, 7.1 ± 6.2 years since diagnosis, 70% males) were enrolled in the Pacific Northwest Udall Center (PANUC), one of the Morris K. Udall Centers of Excellence for Parkinson's Research, Clinical Consortium and underwent comprehensive clinical and neuropsychological assessment. Participants were diagnosed with no cognitive impairment (PD-NCI), mild cognitive impairment (PD-MCI), or dementia (PDD) at a diagnostic consensus conference. RESULTS A substantial proportion of the overall sample was diagnosed with cognitive impairment at baseline: 22% with PDD and 59% with PD-MCI. A higher rate of cognitive impairment was observed in men than women (87% vs. 68%, p < 0.0001), despite a higher level of education. Most patients older than 50 years at the time of diagnosis and with disease duration greater than 10 years were cognitively impaired or demented. CONCLUSIONS The PANUC Clinical Consortium is a clinically and cognitively well-characterized cohort of patients with PD. Baseline cohort characteristics demonstrate a high rate of cognitive impairment in the sample, as well as potential sex differences with regard to cognitive diagnosis. The PANUC Clinical Consortium, with its access to biomarker, genetic, and autopsy data, provides an excellent foundation for detailed research related to cognitive impairment in PD.
In vivo microsampling of enamel fluoride concentrations after topical treatments.

A microsampling technique was used to measure enamel fluoride concentrations before, immediately after, 1 week after, and 3 months after an application of an APF or NH4F solution on the maxillary anterior teeth of 63 children. The fluoride treatments were preceded by a 1-min application of 0.05 m H3PO4. It was found that NH4F produced an initial enamel fluoride level much higher than that produced by APF. One week after treatment, the fluoride concentrations produced by NH4F were still higher than those obtained with APF. Three months after treatment there was no difference between the NH4F and APF groups. Both groups, however, were observed to have lower fluoride concentrations than before treatment.
Reconfigurable Split-Ring Resonators Using Pneumatic Levitation System

In this paper, a pneumatic levitation system is proposed to provide a contactless and metal free platform for dynamically altering the structural arrangement of split-ring resonators in an incident electromagnetic wave. One split ring is placed on a pneumatically levitated platform controlled by different levels of air pressure, and another identical but static split ring is placed underneath to form a broadside coupled arrangement. The proposed pneumatic levitation system has the capability to precisely control the relative orientation of the split ring to the desired rotational angle for on-demand reconfigurability without a sophisticated electrical or mechanical structure. In addition to the rotational angle, the separation between two SRRs can also be reliably controlled by adjusting the pneumatic pressure. The combination of both of these controls enables a large frequency configuration range for broadside coupled SRRs. The corresponding frequency tunability with a 35% bandwidth is validated by both simulations and measurements.
Cognitive Behavioral Therapy for Insomnia, Mindfulness, and Yoga in Patients With Breast Cancer with Sleep Disturbance: A Literature Review

The number of patients with breast cancer diagnosed with sleep disturbance has grown substantially within the United States over the past 20 years. Meanwhile, there have been significant improvements in the psychological treatment of sleep disturbance in patients with breast cancer. More specifically, cognitive behavioral therapy for insomnia (CBT-I), mindfulness, and yoga have shown to be 3 promising treatments with varying degrees of benefit, supporting data, and inherent limitations. In this article, we will outline the treatment approach for sleep disturbance in patients with breast cancer and conduct a comprehensive review of CBT-I, mindfulness, and yoga as they pertain to this patient population.