Miracle-dz/UniFAR-FTUs huggingface dataset:
THE LIFE CYCLE AND DEVELOPMENT OF ASPIDOGASTER CONCHICOLA IN THE SNAILS, VIVIPARUS MALLEATUS AND GONIOBASIS LIVESCENS

The life cycle of Aspidogaster conchicola was completed experimentally in 270 days at 20 C in the snail, Viviparus malleatus. Transmission by embryonated, unhatched eggs was demonstrated un- equivocally. Development of A. conchicola from egg to adult involved three growth phases displaying major shifts in allometric growth of the oral disc, ventral sucker, and body. Alveolar development in the ventral sucker was observed to begin at a growth zone behind the anterior lip of the juvenile posterior sucker. From this region, transverse alveoli were formed and pushed anteriorly by formation of subsequent alveoli. Longitudinal septation of the ventral sucker did not occur until 11 or 12 transverse alveoli were formed. Development of the medial septum slightly preceded that of two laterally situ- ated longitudinal septa. Development of A. conchicola in Goniobasis livescens appeared slightly more rapid than in V. malleatus. The name "aspidocidium" is proposed for the nonciliated juvenile stage of some aspidogastrid species. Since its discovery by von Baer in 1827, Aspidogaster conchicola has been studied only occasionally to determine its development and transmission. Voeltzkow (1888) reported suc- cessful transmission by inserting hatched ju- veniles into the incurrent siphon of presumably uninfected mussels. Several days later, the two experimental hosts each yielded a single im- mature worm from the intestine. Voeltzkow concluded that A. conchicola enters its mussel host via the intestine, penetrating the gut wall
Optimisation of the media for in vitro shoot proliferation and root induction in three new cold-hardy and dwarfing or semi-dwarfing clonal apple rootstocks

Summary Rootstocks have been used to influence precocity, tree size, fruit quality, yield efficiency, and mineral uptake, and to withstand adverse environmental conditions in many fruit tree species. However, some apple (Malus × domestica Borkh.) rootstocks with excellent horticultural characteristics are difficult to propagate by conventional methods. Tissue culture can be used to propagate new rootstocks developed from breeding programmes for use in experimental trials and for the rapid large-scale production of rootstocks for commercial production. The aim of this study was to propagate several newly-introduced apple rootstocks which were cold-hardy and dwarfing, or semi-dwarfing, and to improve their rooting ability through tissue culture. Major factors that influenced shoot proliferation and rooting were examined and optimal media were developed for the efficient micropropagation and rooting of in vitro shoots of the apple rootstocks ‘GM256’, ‘Budagovsky 71-3-150’, and ‘Budagovsky 60-160’. The optimum proliferation medium for all three apple rootstocks was Quoirin and Lepoivre (QL) medium containing 0.5 mg l–1 6-benzylaminopurine (BAP) and 0.05 mg l–1 indole-3-butyric acid (IBA). Shoot explants of ‘Budagovsky 60-160’ on 1.0× Murashige and Skoog (MS) proliferation medium, 0.75× MS, or 0.5× MS showed shoot tip necrosis and hyperhydricity. Rooting percentages and numbers of roots per plantlet were highest using dark culture for all three rootstocks. The highest rooting percentages for all three rootstocks were obtained on 0.5× QL medium containing 0.5 mg l–1 IBA and 2% (w/v) sucrose, but the rooting percentage of ‘Budagovsky 60-160’ was not significantly different between 0.25× MS and 0.5× QL rooting media.
Understanding properties of the master effector of phage shock operon in Mycobacterium tuberculosis via bioinformatics approach

The phage shock protein (Psp) is a part of the Psp operon, which assists in safeguarding the survival of bacterium in stress and shields the cell against proton motif force challenge. It is strongly induced by bacterium allied phages, improperly localized mutant porins and various other stresses. Master effector of the operon, PspA has been modeled and simulated, illustrating how it undergoes significant conformational transition at the far end in Mycobacterium tuberculosis. Association of this key protein of the operon influences action of Psp system on the whole. We are further working on the impact of phosphorylation perturbation and changes in the structure of PspA during complex formation with other moieties of interest.
The role of proteinuria and proximal tubular cells in the development of tubulointerstitial inflammation and scarring in the kidney

S: 1. Burton CJ. Beviugton A, Harris KPG and Walls J. The response of cultured proximal tubular cells to alburnin and protemmic mine. J Am Soc Nephrol 3: p735, 1992. 25th Annual Meeting of the American Society of Nephrology, Baltimore 1992. (poster presentation) 2. Burton CJ. Harris KPG and Walls J. Urine from rats with pmomycin (PAN) nephrosis is chemoattractant for monocytes. Nephrol Dial Transplant 8 : p894, 1993. 30th Congress of the Emopean Dialysis and Transplantation Association, Glasgow 1993. (oral presentation)
Reply

1. Berzigotti A, Reig M, Abraldes JG, Bosch J, Bruix J. Portal hypertension on the outcome of surgery for hepatocellular carcinoma in compensated cirrhosis: a systematic review and meta-analysis. HEPATOLOGY 2015; 61:526-536. 2. Zhong JH, Ke Y, Wang YY, Li LQ. Liver resection for patients with hepatocellular carcinoma and macrovascular invasion, multiple tumours, or portal hypertension. Gut 2014 Sep 3. pii: gutjnl-2014-308139. doi: 10.1136/gutjnl-2014-308139. [Epub ahead of print]. 3. Zhong JH, Li H, Xiao N, Ye XP, Ke Y, Wang YY, et al. Hepatic resection is safe and effective for patients with hepatocellular carcinoma and portal hypertension. PLoS One 2014;9:e108755. 4. Zhong JH, Ke Y, Gong WF, Xiang BD, Ma L, Ye XP, et al. Hepatic resection associated with good survival for selected patients with intermediate and advanced-stage hepatocellular carcinoma. Ann Surg 2014;260: 329-340. 5. Boleslawski E, Petrovai G, Truant S, Dharancy S, Duhamel A, Salleron J, et al. Hepatic venous pressure gradient in the assessment of portal hypertension before liver resection in patients with cirrhosis. Br J Surg 2012;99:855-863.
Reply:

We thank Luo et al. for their interest in our recent publication which highlighted the high healthcare costs and resource utilization among patients with nonalcoholic fatty liver disease (NAFLD)(1). They raised an important question regarding the impact of resource utilization on mortality in general and cardiovascular-related death in particular. In this analysis using OptumLabs® Data Warehouse (OLDW), the largest drivers of cost were tests focused on assessment of liver disease etiology and severity. Whether the use of these tests ultimately impacts patient survival is a critical question, but one that cannot be definitively addressed using administrative databases such as OLDW. This is particularly true for chronic diseases such as NAFLD, where mortality is expected to occur years to decades after disease onset(2). This article is protected by copyright. All rights reserved.
Reply

1. Fukumoto S. Actions and mode of actions of FGF19 subfamily members. Endocr J 2008;55:23-31. 2. Itoh N. Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease. Cell Tissue Res 2010; 342:1-11. 3. Kharitonenkov A. FGFs and metabolism. Curr Opin Pharmacol 2009;9: 805-810. 4. Zweers SJ, Booij KA, Komuta M, Roskams T, Gouma DJ, Jansen PL, et al. The human gallbladder secretes fibroblast growth factor 19 into bile: towards defining the role of fibroblast growth factor 19 in the enterobiliary tract. HEPATOLOGY 2012;55:575-583. 5. Lundåsen T, Gälman C, Angelin B, Rudling M. Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man. J Intern Med 2006;260:530-536.
Dual attention multiple instance learning with unsupervised complementary loss for COVID-19 screening

Chest computed tomography (CT) based analysis and diagnosis of the Coronavirus Disease 2019 (COVID-19) plays a key role in combating the outbreak of the pandemic that has rapidly spread worldwide. To date, the disease has infected more than 18 million people with over 690k deaths reported. Reverse transcription polymerase chain reaction (RT-PCR) is the current gold standard for clinical diagnosis but may produce false positives; thus, chest CT based diagnosis is considered more viable. However, accurate screening is challenging due to the difficulty in annotation of infected areas, curation of large datasets, and the slight discrepancies between COVID-19 and other viral pneumonia. In this study, we propose an attention-based end-to-end weakly supervised framework for the rapid diagnosis of COVID-19 and bacterial pneumonia based on multiple instance learning (MIL). We further incorporate unsupervised contrastive learning for improved accuracy with attention applied both in spatial and latent contexts, herein we propose Dual Attention Contrastive based MIL (DA-CMIL). DA-CMIL takes as input several patient CT slices (considered as bag of instances) and outputs a single label. Attention based pooling is applied to implicitly select key slices in the latent space, whereas spatial attention learns slice spatial context for interpretable diagnosis. A contrastive loss is applied at the instance level to encode similarity of features from the same patient against representative pooled patient features. Empirical results show that our algorithm achieves an overall accuracy of 98.6% and an AUC of 98.4%. Moreover, ablation studies show the benefit of contrastive learning with MIL.
Postweaning maternal care increases male chimpanzee reproductive success

Sons orphaned before aged 12 reproduce less, indicating long dependency and a model for human’s slow ontogeny. Humans are unusual among animals for continuing to provision and care for their offspring until adulthood. This “prolonged dependency” is considered key for the evolution of other notable human traits, such as large brains, complex societies, and extended postreproductive lifespans. Prolonged dependency must therefore have evolved under conditions in which reproductive success is gained with parental investment and diminished with early parental loss. We tested this idea using data from wild chimpanzees, which have similarly extended immature years as humans and prolonged mother-offspring associations. Males who lost their mothers after weaning but before maturity began reproducing later and had lower average reproductive success. Thus, persistent mother-immature son associations seem vital for enhancing male reproductive success, although mothers barely provision sons after weaning. We posit that these associations lead to social gains, crucial for successful reproduction in complex social societies, and offer insights into the evolution of prolonged dependency.
Isolation, identification, and pathogenicity of Steinernema carpocapsae and its bacterial symbiont in Cauca-Colombia

Abstract In Colombia, identification of entomopathogenic nematodes (EPN’s) native species is of great importance for pest management programs. The aim of this study was to isolate and identify EPNs and their bacterial symbiont in the department of Cauca-Colombia and then evaluate the susceptibility of two Hass avocado (Persea americana) pests to the EPNs isolated. EPNs were isolated from soil samples by the insect baiting technique. Their bacterial symbiont was isolated from hemolymph of infected Galleria mellonella larvae. Both organisms were molecularly identified. Morphological, and biochemical characterization was done for the bacteria. Susceptibility of Epitrix cucumeris and Pandeleteius cinereus adults was evaluated by individually exposing adults to 50 infective juveniles. EPNs were allegedly detected at two sampled sites (natural forest and coffee cultivation) in 5.8% of the samples analyzed. However, only natural forest EPN’s could be isolated and multiplied. The isolate was identified as Steinernema carpocapsae BPS and its bacterial symbiont as Xenorhabus nematophila BPS. Adults of both pests were susceptible to S. carpocapsae indicating this EPN potential for its management. The results of this study constitute the first record of S. carpocapsae in Colombia and the susceptibility of P. cinereus to this EPN.
Antecedents and consequences of brand hate: empirical evidence from the telecommunication industry

PurposeThe purpose of this study is to place the antecedents and consequences of brand hate in the context of negative consumer–brand relationship in the telecommunication industry. It provides a response to the existing gap in the research on brand hate in consumer behavior in service brands.Design/methodology/approachA survey-based data was modeled after theory that aims to apply concepts to the telecommunications industry. With a solid model grounded and context-adapted, a mediation analysis of the role of brand hate in negative antecedents and consequences toward brands was performed.FindingsBrand hate was found to mediate all the negative relationships proposed, while showing to be especially significant in mediating negative word of mouth. This model appropriately fits the services' marketing brand and revealed new insights into the function of brand hate in negative relationships that are specific to service marketing consumer brands.Research limitations/implicationsBranding theory may benefit from deeper insights into the negative side of consumer–brand relationships. A broader illustration of its constituents in different industries and the recovery of the management approach to these circumstances bring innovation and a richer understanding, specially to the role of brand hate in the mediation context as seen in the literature (Hegner et al., 2017; Zarantonello et al., 2016)Practical implicationsManagerial implications include assessing brands in analyzing and relating to different emotions and concepts from customers, allowing to prioritize and mapping the customer relationship touchpoints.Originality/valueThe present study presents a first insight of brand hate in the context of the service industry of telecommunications in southern Europe while testing brand hate as a mediator involving negative predictors leading to negative outcomes in consumer–brand relationships.
POTENTIAL BENEFITS ASSESSMENT ON HOME DELIVERY SERVICE USING MULTIPLE DRONES

A tandem home delivery service combining a drone and a truck has attracted worldwide attention. We proposed a multi-objective path planning method for the tandem delivery problem in past research. In addition, we showed quantitatively how much the drone contributes to cost reduction of the delivery service by using this method. However, the proposed method has some drawbacks. For example, problem setting applicable to this method is very limited, and there may be cases where the optimization cannot be performed depending on the characteristics of the objective function. Therefore, we propose a new method to solve these problems in this paper. By using the improved method, it became possible to generate multiple delivery routes at the same time. Moreover, we also found that the effect of cost reduction by drone greatly varies depending on preset constraint conditions by evaluating the potential benefits of the drone again. For this reason, it can be said that additional analyses are necessary to maximize the benefits of the drone in the delivery service.
Population genetic structure of Epinephelus marginatus in the Central Mediterranean Sea (Gulf of Gabès and the coast of Libya)

In the present study, mitochondrial DNA sequences from the cytochrome b (cytb) gene and seven nuclear microsatellites were examined to assess the genetic diversity of Epinephelus marginatus inhabiting Tunisian and Libyan coastal waters. Based on 940 base pairs of the cytochrome b segment, we found low level of genetic variability for the two samples analysed (h = 0.294 ± 0.097and h = 0.274± 0.142 respectively in Tunisia and Libya). An analysis of molecular variance (AMOVA) showed significant pattern of genetic structure based on nuclear data (7 microsatellite loci) (ΦST= 0.28487; P < 0.001). Conversely, no genetic structuring was found for mtDNA (ΦST = -0.0121). In summary, this study provides preliminary assessment of geographical patterns of differentiation of E. marginatus in this region for conservation, management and stock identification.
MULTI-NUCLEON TRANSFER REACTIONS IN U+Ni USING GRAZING MODEL

Multi-nucleon transfer (MNT) reactions give access to heavy exotic neutron-rich nuclei which are difficult to be produced by fission or in fragmentation reactions. The U+Ni MNT reactions taking place inside a gas cell, is simulated with the GRAZING code. Simulations of the release of reaction product from the target and of their slowing down in the He gas of the cell are performed with the GEANT4 software. The space charge effects induced by gas ionization are studied with the SIMION program. The implications for an experimental program using such a setup are discussed.
Ductal Carcinoma In Situ with Diffuse Growth Distribution:A Potentially Lethal Subtype of Preinvasive Disease

PURPOSE: The current trend in ductal carcinoma in situ (DCIS) research is towards treatment de-escalation. Problematically, prognostic indicators for patients at high risk of breast cancer mortality (BCM), rather than recurrence, have not been identified. We aim to identify prognostic factors for the development of metastatic disease and mortality. EXPERIMENTAL DESIGN: Patients diagnosed with DCIS in a local cancer registry as well as in the National Cancer Database (NCDB) and the Surveillance, Epidemiology and End Results (SEER) program were assessed for factors prognostic of metastatic disease, overall, and breast-cancer specific survival. Cox and competing risks regressions were developed. RESULTS: Among 5 patients who developed distant metastatic disease in the cancer registry, 3 had identifiable growth distribution; all 3 were diffuse type. None had in-breast invasive or DCIS recurrences before metastasis. In NCDB and SEER, cumulative incidence of any cause mortality (ACM) and BCM at 10 years was 12%/5.0% for diffuse lesions; 8%/3.6% for patients with microinvasive disease, 7.4%/2.3% for lesions >5 cm, 5.6%/1.4% for lesions 2-5 cm and 5.5%/1.5% for lesions <2 cm. Multivariate hazard ratios for ACM in NCDB and BCM in SEER were 2.0 and 5.3 (p=0.03 and 0.02, respectively). Among patients with diffuse lesions, cumulative incidence ACM at 10 years was 15.0% among those undergoing unilateral mastectomy vs. 2.5% among those undergoing bilateral mastectomy (p=0.11). CONCLUSION: Diffuse DCIS represents an uncommon but deadly subtype for whom treatment escalation, rather than de-escalation, is likely necessary. Further studies elucidating the mechanism of metastasis and best treatment course are needed.
An Initial Psychometric Evaluation of the APS-POQ-R in Acute Pain Presenting to the Emergency Department

Background: Pain is a common presenting complaint to the emergency department (ED), yet is often undertreated. When assessing the outcomes of pain care in the ED, process measures are commonly reported. Attempts to measure patient reported outcomes existing in current ED literature. However, they are frequently unvalidated and lack standardization. The American Pain Societies, Patient Outcome Questionnaire, Revised edition (APS POQ R) has been identified as the most likely, preexisting tool to be useful in the acute pain in the ED. However, this requires feasibility and construct validation before use. Objective: To assess the feasibility and construct validity of the APS POQ R in patients presenting to the adult emergency department with acute pain. Methods: This study is an initial psychometric evaluation of the constructs contained within the APS POQ R in adult patients presenting with moderate to severe acute pain to a large urban ED. The study is guided by the methods described in the initial development of the instrument. Results: Two hundred adult patients were recruited and completed the APS POQ R. The APS POQ R demonstrated content validity in patients presenting with acute pain. Exploratory factor analysis demonstrated five subgroups. The tool demonstrated discriminatory ability based on patient urgency, and subscale measurement was associated with patient satisfaction with care. Conclusions: The APS POQ R has demonstrable construct validity in adult patients presenting with acute pain to the ED. Further psychometric analysis across multiple EDs is required before the APS POQ R can be recommended as a validated PROM for ED patients in pain.
Deep Learning Approach to Parse Eligibility Criteria in Dietary Supplements Clinical Trials Following OMOP Common Data Model

Dietary supplements (DSs) have been widely used in the U.S. and evaluated in clinical trials as potential interventions for various diseases. However, many clinical trials face challenges in recruiting enough eligible patients in a timely fashion, causing delays or even early termination. Using electronic health records to find eligible patients who meet clinical trial eligibility criteria has been shown as a promising way to assess recruitment feasibility and accelerate the recruitment process. In this study, we analyzed the eligibility criteria of 100 randomly selected DS clinical trials and identified both computable and non-computable criteria. We mapped annotated entities to OMOP Common Data Model (CDM) with novel entities (e.g., DS). We also evaluated a deep learning model (Bi-LSTM-CRF) for extracting these entities on CLAMP platform, with an average F1 measure of 0.601. This study shows the feasibility of automatic parsing of the eligibility criteria following OMOP CDM for future cohort identification.
THE REMOTE ANALYSIS OF BREATH SOUND IN COVID-19 PATIENTS: A SERIES OF CLINICAL CASES

Background: Respiratory sounds have been recognized as a possible indicator of behavior and health. Computer analysis of these sounds can indicate of characteristic sound changes caused by COVID-19 and can be used for diagnosis of this illness. Purpose: The communication aim is development of fast remote computer-assistance diagnosis of COVID-19, based on analysis of respiratory sounds. Materials and Methods: Fast Fourier transform (FFT) was applied for analyses of respiratory sounds recorded near the mouth of 9 COVID-19 patients and 4 healthy volunteers. Sampling rate was 48 kHz. Results: Comparing of FFT spectrums of the respiratory sounds of the patients and volunteers we proposed numerical healthy-ill criterions. Conclusions: The proposed computer method, based on analysis of the FFT spectrums of respiratory sounds of the patients and volunteers, allows one to automatically diagnose COVID-19 with sufficiently high diagnostic values. This method can be applied at development of noninvasive self-testing kits for COVID-19.
Tracing the source of oxidizing fluids in subduction zones using iron isotopes in garnet

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UvA-DARE ( Digital Academic Repository ) Modelling the Generation and Retrieval of Word Associations with Word Embeddings

Citation for published version (APA): Dankers, V. , Bilgin, A. , & Fernández, R. (2017). Modelling the Generation and Retrieval of Word Associations with Word Embeddings: A Case Study for a Guesser Agent in the Location Taboo Game. In B. Verheij, & M. Wiering (Eds.), BNAIC 2017: Benelux Conference on Artificial Intelligence: Preproceedings of the 29th Benelux Conference on Artificial Intelligence, November 8–9, 2017 in Groningen, The Netherlands (pp. 401-402). (BNAIC; Vol. 29). Groningen: University of Groningen.