Miracle-dz/UniFAR-FTUs huggingface dataset:
Tumor cell-activated “Sustainable ROS Generator” with homogeneous intratumoral distribution property for improved anti-tumor therapy

Photodynamic therapy (PDT) holds a number of advantages for tumor therapy. However, its therapeutic efficiency is limited by non-sustainable reactive oxygen species (ROS) generation and heterogeneous distribution of photosensitizer (PS) in tumor. Herein, a “Sustainable ROS Generator” (SRG) is developed for efficient antitumor therapy. Methods: SRG was prepared by encapsulating small-sized Mn3O4-Ce6 nanoparticles (MC) into dendritic mesoporous silica nanoparticles (DMSNs) and then enveloped with hyaluronic acid (HA). Due to the high concentration of HAase in tumor tissue, the small-sized MC could be released from DMSNs and homogeneously distributed in whole tumor. Then, the released MC would be uptaken by tumor cells and degraded by high levels of intracellular glutathione (GSH), disrupting intracellular redox homeostasis. More importantly, the released Ce6 could efficiently generate singlet oxygen (1O2) under laser irradiation until the tissue oxygen was exhausted, and the manganese ion (Mn2+) generated by degraded MC would then convert the low toxic by-product (H2O2) of PDT to the most harmful ROS (·OH) for sustainable and recyclable ROS generation. Results: MC could be homogeneously distributed in whole tumor and significantly reduced the level of intracellular GSH. At 2 h after PDT, obvious intracellular ROS production was still observed. Moreover, during oxygen recovery in tumor tissue, ·OH could be continuously produced, and the nanosystem could induce 82% of cell death comparing with 30% of cell death induced by free Ce6. For in vivo PDT, SRG achieved a complete inhibition on tumor growth. Conclusion: Based on these findings, we conclude that the designed SRG could induce sustainable ROS generation, homogeneous intratumoral distribution and intracellular redox homeostasis disruption, presenting an efficient strategy for enhanced ROS-mediated anti-tumor therapy.
Synthesis, antimicrobial and antioxidant activities of some novel cyclized naphthyl cyclohexanone derivatives

2-((Naphthalen-1-or-2-yl)methylene)cyclohexanone (1a,b) were synthesized through condensation of 1- and/or 2-naphthaldehyde with cyclohexanone. The cyclization of 1a,b with substituted hydrazines gave the corresponding hexahydroindazole derivatives 2a,b-6a,b. While on condensation with hydroxylamine hydrochloride and/or thiourea gave benzoisoxazole derivative 7a,b and quinazoline-2-thione derivative 8a,b. Also condensation of 1a,b with guanidine sulphate followed by chloroacetylation gave 10a,b which were condensed with ortho substituted aniline gave quinazoline derivatives 11a,b, 12a,b. Condensation of 1a,b with various active methylene compounds afforded the corresponding chromene derivatives 13a,b-15a,b. The antimicrobial activity of the newly synthesized compounds was done against different gram positive, gram negative bacteria and fungi species. Also the antioxidant activity of these compounds was evaluated.
Gut Flora Mediated Mouse Metabolic Health Risk Caused by Dietary Exposure of Acetamiprid and Tebuconazole

Background:Dietary pesticide residue is an important dietary inducement of metabolic syndrome. Results:Chronic inflammation, insulin resistance, obesity, and non-alcoholic fatty liver disease were induced to tested mice through long-term and low-level of acetamiprid and tebuconazole. On the basis of these phenotypes, the mouse gut flora with metabolites, host circulation metabolic profiling, and their interrelations were investigated, and host metabolic pathways were detected. Results showed that pesticide exposure differently altered the abundance of gut microbial species, such as high ratio of Firmicutes/Bacteroidetes and increased high lipopolysaccharide-production species. Correlation analysis between gut flora and its metabolic profiling further explained these changes and their associations. Under these influences, metabolic profiling of host serum and liver was performed, and metabolic disorders were characterized. The relationships between serum and gut flora were determined via their significantly different metabolites. Alterations to the metabolic pathways of liver were clarified to deeply explore the influences on host physiology. Host metabolic disorders were evidently released by fructooligosaccharide and fecal microbiota transplantation intervention, directly proving that gut flora is a vital medium in metabolic health risk caused by pesticide exposure.Conclusion:Dietary long-term and low-level pesticides threated metabolic health via affecting intestinal flora. Metabolism of intestinal flora and host were all stressed by the exposure, and their alterations were in close proximity. Dietary interventions mitigated metabolic diseases via improving disorder of intestinal flora. This work supplied theoretical bases and intervention approaches to body metabolic problems caused by pesticides exposure on the basis of gut flora.
High-level Ab Initio Studies of the Spectroscopic Properties of Triatomic [Al, S, O]x (x = 0, +1) and Its Potential for Detection in Space

Highly reliable molecular properties have been computed for the [Al, S, O]x (x = 0, +1) molecular system. Spectroscopic parameters are predicted from analysis of each isomer’s 3D potential energy surface calculated using the explicitly correlated multireference configuration interaction method, including the Davidson correction (MRCI-F12+Q). These parameters provide an accurate prediction of spectroscopic data that can be used in laboratory and observational studies of these molecules. Linear-SAlO is expected to have a large permanent dipole moment suitable for detection in the circumstellar envelopes of large, evolved, oxygen-rich stars such as VY Canis Majoris, IK Tauri, and R Doradus. Frequencies are provided for rotational transitions originating from the most highly populated rotational state based on a Boltzmann distribution. Additionally, both linear isomers exhibit a flat potential along the bending angle and are predicted to have very low bending mode frequencies (<200 cm−1), complicating the spectra of these molecules.
OPTIMALISASI PENCAHAYAAN GEDUNG BERPEDOMAN PADA STANDAR NASIONAL DAN GREEN BUILDING COUNCIL INDONESIA

Desain gedung dengan pencahayaan dan penghawaan alami yang cukup menjadi suatu keharusan dimasa mendatang dalam upaya penghematan konsumsi energi, terciptanya bangunan yang sehat dan ramah lingkungan. Oleh sebab itu terapan konsep green building secara tepat terutama didaerah tropis seperti Indonesia sangat diperlukan. Tiga aspek penting mengapa perlunya penerapan konsep green building, yaitu pemanasan global (global warming), perubahan iklim (climate change) dan terjadinya penurunan kualitas lingkungan (environmental deteriorations). Penelitian ini merupakan penelitian dasar yang menyangkut bidang ilmu rekayasa dengan tema teknologi konservasi energi pada desain gedung. Jenis penelitian adalah descriptive-method dengan metode pendekatan mixed method, teknik pengumpulan data menggunakan triangulasi yaitu survey,observasi visual dan pengukuran. Sebagai objek kasus penelitian adalah Gedung Call Center Telkomsel (CCT) Bandung, dimana hamper keseluruhan desain arsitektur eksterior (building envelope) menggunakan material kaca. Dugaan secara visual bahwa desain gedung seperti ini akan mempengaruhi kenyamanan termal dalam ruangan akibat radiasi matahari langsung yang cukup besar. Penelitian ini bertujuan mengoptimalkan pencahayaan dalam gedung sesuai dengan standar dan konsep green building. Luaran penelitian dan luaran tambahan adalah Laporan akhir, publikasi pada jurnal terakreditasi serta desain ulang pencahayaan dan fisik fasade Gedung CCT sesuai standar pencahayaan dan konsep banguna hijau (green building) yang ramah lingkungan serta hemat energi.
Gradient and categorical assimilation of pretonic vowels in Brazilian Portuguese

This paper addresses the acoustic realisations of the pretonic vowels /e, o/ that have been previously reported to undergo regressive vowel harmony in Brazilian Portuguese. It examines how the height of pretonic /e, o/ is affected by the phonological and phonetic height of the adjacent stressed vowel in three dialects: Northeastern (Bahia), Northern (Amazonas) and Southern (Rio Grande do Sul). A pseudoword reading task was performed with two speakers each of the three different dialects. The findings suggest that there is some kind of low harmony, in that /e, o/ are realized with markedly higher F1 before the stressed low vowels /ɛ, a, ɔ/ than before the stressed non-low vowels /i, e, o, u/. This effect was found for all dialects, but appears to be categorical (and thus phonological) for the Northern and Northeastern speakers, while gradient for the Southern speakers, where it is likely due to phonetic V-to-V coarticulation. More importantly, no effect of height harmony was found in any of the dialects: pretonic /e, o/ were not produced significantly higher before a stressed /i, u/. In addition, Northern and Southern speakers showed V-to-V coarticulation for the non-high pretonic vowels, illustrating with Northern speakers that a categorical harmony process can co-occur together with a gradient vowel assimilation in the same dialect.
ATC Mw7.1 Puebla–Morelos earthquake reconnaissance observations: Seismological, geotechnical, ground motions, site effects, and GIS mapping

This article presents the Applied Technology Council (ATC) team’s observations following the 2017 Mw7.1 Puebla–Morelos, Mexico earthquake. The team was deployed in Mexico City to collect seismological, geotechnical, structural, and overall performance information. The focus was on non-ductile concrete structures, to support implementation of recently published FEMA P-2018 procedures and to identify study buildings for incorporation into NIST-funded ATC-134 ongoing project. This article presents seismological data with 71 strong-motion records processed and ready for use in engineering analysis, geotechnical observations, and characterization of sites visited. Analyses of the response of representative soil profiles are presented in the form of acceleration response spectra and seismic amplification at the ground surface. A comparison of the same analysis using records from the 1985 Michoacán Ms8.1 (approximately Mw8.0) earthquake is also discussed. The ATC team composed GIS maps with structural and geotechnical characteristics of the inspected sites, including color-coded damage of inspected buildings and estimated soil fundamental period to correlate observed behavior with potential soil–structure interaction resonance effects. Recommendations on further detailed studies based on this comprehensive set of case histories are proposed.
Effective degassing of HIP canisters through the use of residual gas analysis

Effective degassing of HIP canisters is paramount to producing high quality components by prevention of the retention of atmospheric contaminants such as oxygen, nitrogen, hydrogen and argon. These contaminants are responsible for defects that lead to poor materials performance and reducing confidence in HIP products. The solution to degassing of large HIP canisters ready for processing is often met with extended degassing times to ensure adequate evacuation. We present the use of residual gas analysis by spectroscopy for the enhancement of the degassing process and compare the amount of time required for degassing of different powders exposed to varied atmospheric conditions. We consider the use of an automated algorithm to detect and notify users when degas is complete based on the residual gas analysis to shorten processing times for HIP parts, whilst ensuring quality.
Layered Sodium Disilicates as Precursors of Mesoporous Silicas. Part II: Hydration of δ-Na2Si2O5 and α-Na2Si2O5

Layered Sodium Disilicates as Precursors of Mesoporous Silicas. Part II: Hydration of δ-Na2Si2O5 and α-Na2Si2O5 Reaction of δ-Na2Si2O5 and α-Na2Si2O5 with water at ambient conditions has been studied. The first substrate produced kanemite, the other a crystalline solid, assumed to be the layered hydrated α phase of yet unknown structure. Important differences have been observed in the kinetics of δ-Na2Si2O5 and α-Na2Si2O5 reactions with water, the phase transformation of the latter being distinctly slower. The observed different rates of hydration were associated with the different structural properties of the disilicates investigated. Hydrated δ-Na2Si2O5 and α-Na2Si2O5 possess, respectively, the platy and the needle-like morphology. Hydrated α-Na2Si2O5 contains less interlayer water, which is considered the reason for basal spacing being lower than that of kanemite. The interlayer water trapped between the layers of hydrated α-Na2Si2O5 is more strongly bound than that in kanemite. Warstwowe krzemiany sodu jako prekursory mezoporowatych krzemionek. II: Hydratacja δ-Na2Si2O5 i α-Na2Si2O5 Reakcje δ-Na2Si2O5 i α-Na2Si2O5 z wodą prowadzą do powstania uwodnionych krzemianów sodu, odpowiednio - kanemitu (z fazy δ-Na2Si2O5) i z fazy α - jej uwodnionej formy o nieznanej strukturze. Kinetyki hydratacji tych krzemianów są zdecydowanie różne; faza δ ulega szybkiej transformacji, faza α - wolnej. Różne szybkości hydratacji można wiązać z różnicami strukturalnymi obu krzemianów sodu. Uwodniony δ-Na2Si2O5 wykształcony jest w formie płytek, podczas gdy uwodniony α-Na2Si2O5 ma morfologię typu igieł. Różna jest również ilość wody międzypakietowej w obu hydratach; uwodniony δ-Na2Si2O5 posiada jej więcej ale słabiej związanej, natomiast uwodniony α-Na2Si2O5 mniej, lecz związanej silniej.
Genetic Manipulation and Transformation Methods for Aspergillus spp.

Abstract Species of the genus Aspergillus have a variety of effects on humans and have been considered industrial cell factories due to their prominent ability for manufacturing several products such as heterologous proteins, secondary metabolites, and organic acids. Scientists are trying to improve fungal strains and re-design metabolic processes through advanced genetic manipulation techniques and gene delivery systems to enhance their industrial efficiency and utility. In this review, we describe the current status of the genetic manipulation techniques and transformation methods for species of the genus Aspergillus. The host strains, selective markers, and experimental materials required for the genetic manipulation and fungal transformation are described in detail. Furthermore, the advantages and disadvantages of these techniques are described.
Environmental Status of Cobalt and Its Microdetermination With 7-Nitroso-8-Hydroxyquinoline-5-Sulfonic Acid In Waters, Aquatic Weeds and Animal Tissues

Abstract A method is presented for the spectrophotometric microdetermination of cobalt (II) in fresh waters, aquatic weeds, and animal tissues employing 7-nitroso-8-hydroxyquinoline-5-sulfonic acid. the method enables direct determination of cobalt (II) in presence of a large number of anions and cations commonly associated with cobalt, and is adequate for determining the metal in the concentration range of 0.001–10 ppm, which is commonly encountered in environmental samples.
An Overview of the Bionomics, Host Plant Resistance and Molecular Perspectives of Sesamia inferens Walker in Cereals and Millets

There is an urgent need to enhance agricultural production as well as productivity to meet the food demand of the growing population, estimated to be 10 billion by 2050, using a holistic and sustainable approach. The daily food sources for almost three-fourth of the global population, cereals and millets, are prone to several biotic factors and abiotic pressures. In particular, cereals and millet cultivation are limited by the polyphagous pink stem borer, Sesamia inferens Walker (Lepidoptera:Noctuidae) gaining national importance, since its larvae and pupae are concealed within the stem, none of the management measures have been found effective in controlling the menace. However, host plant resistance (HPR) is a reasonable and ecologically safe method wherein resistance mechanisms of crops could lower the stem borer infestation. The foremost challenge in understanding the mechanism would be to detecting the genes of interest in the crop using novel biotechnological approaches. The fundamental criterion for developing insect-resistant lines relies on recognizing the mechanism of plant resistance. The entire life cycle of this group of borers is completed or hidden within the stem, posing a hurdle in their management. Thus, molecular markers and Quantitative Trait Locus (QTL) mapping offer a more efficient approach to entomologists and plant breeders wherein they can work with traits like QTLs for stem borer resistance. In this review, an attempt has been made to provide an extensive summary of the host range and crop losses due to this borer, besides its taxonomic position, geographic distribution, bionomics, genetics of resistance, and molecular perspectives.
Foreword: Advances in Multi-Parametric, Time-Dependent Assessment of Seismic Hazard and Earthquakes Forecast

Until now proposed Operational Earthquakes Forecast (OEF) methods suffer of strong limitations in terms of their actual (too low absolute value of estimated probabilities) and general (forecast is substantially limited to earthquakes which are preceded by foreshocks) operational applicability [e.g. Wang and Rogers, 2014; Panza et al., 2014]. They become of some (unfortunately still marginal) usefulness just when such a low-probabilities are multiplied for very high exposure and/or vulnerability factors in order to obtain significant amounts of the estimated seismic risk. Mostly, due to these limitations they have been scarcely used in the past while the interest of the scientific community for the study of additional, not just seismological, geophysical/geochemical parameters that could provide useful indications about the evolution of seismic hazard in the medium/short term, is every day increasing.
Nursing care of a case of mediastinal tumor resection combined with postoperative thoracic hemorrhage after video-assisted thoracoscopic surgery (VATS)

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The impact of COVID-19 on ASEAN

Abstract Starting in December 2019, COVID-19 had been spreading across the world on a limited scale for a quarter until March 2020 when the death toll in the countries comprising the Association of Southeast Asian Nations (ASEAN) finally started to mount. However, despite the relatively late outbreak in the region, the ASEAN market had already plunged along with other regional markets across the world amid heightened concern about the economic impact of the biggest viral killer in 2020. In this paper, we examine the economic impact of coronavirus on different ASEAN countries separately by analysing their respective economic figures for the first two quarters in 2020. This allows us to delineate the overall picture of its impact on ASEAN countries as well as to provide an estimation for the future outlook of the ASEAN economic bloc. We propose that the slowing growth, the sluggish recovery of trade and the cross-country transmission of unemployment are three significant risk factors that the ASEAN economies are faced with.
The Social Identity Of Greeks Living In Different Territories

The article presents a study aimed at identifying the specifics of the social identity of Greeks from different territories. The study involved 96 people, divided into 3 groups: Greeks, born and residing in the territory of the Hellenic Republic; ethnic Greeks who repatriated from the countries of the former USSR; ethnic Greeks living in the territory of the former USSR. The results of the study show that for all respondents, regardless of place of residence, family ranks first in the structure of social identity. No significant differences were revealed between native and repatriated Greeks in the three main categories of social identity formation. The specificity of territorial and linguistic identity in the three groups was disclosed. Despite certain differences, the similarity of native and repatriated Greeks, as opposed to the Greeks of the diaspora, was revealed in different value orientations and preferences, which indicates the transformation of the social identity of the repatriated and its convergence with the social identity of the native population. A similar type of formation of social identity with the native Greeks is evidence in favour of the successful socialisation of the repatriated. The hypothesis of a correlation between the significance of family as a criterion of social identification with the level of resilience in conditions of resocialisation was confirmed. The coincidence of the priority identification categories for the repatriated Germans and Greeks suggests that this is a general type of social identification in the process of
The Russians are Laughing! The Russians are Laughing! How Russian Diplomats Employ Humour in Online Public Diplomacy

ABSTRACT In recent years, diplomats have increasingly employed humour online. This study sought to understand why diplomats use humour on Twitter and to investigate whether humour can serve as a public diplomacy resource. The study adopted the prism of “the digitalisation of public diplomacy”, which asserts that the norms and logics of the digital society have altered diplomats’ working routines. Employing advertising humour typologies, the study analysed humorous tweets published by the Russian Embassy to the United Kingdom. Results suggest that by adopting a humorous and abrasive tone, and resonating with populist narratives, the Embassy was able to craft a unique iBrand online. This iBrand also depicted Russia as a confident world leader whose diplomacy is blunt and understandable to “common” people. Humour also enabled the Embassy to summon the attention of social media users, set the media agenda and identify the values that underscore Russia’s image.