Miracle-dz/UniFAR-FTUs huggingface dataset:
Nutrient Requirements and Optimal Nutrition Pregnancy and Lactation Alter Biomarkers of Biotin Metabolism in Women Consuming a Controlled Diet 1 – 3

Biotin functions as a cofactor for several carboxylase enzymes with key roles in metabolism. At present, the dietary requirement for biotin is unknown and intake recommendations are provided as Adequate Intakes (AIs). The biotin AI for adults and pregnant women is 30 mg/d, whereas 35 mg/d is recommended for lactating women. However, pregnant and lactating women may require more biotin to meet the demands of these reproductive states. The current study sought to quantify the impact of reproductive state on biotin status response to a known dietary intake of biotin. To achieve this aim, we measured a panel of biotin biomarkers among pregnant (gestational week 27 at study entry; n = 26), lactating (postnatal week 5 at study entry; n = 28), and control (n = 21) women who participated in a 10to 12-wk feeding study providing 57 mg of dietary biotin/d as part of a mixed diet. Over the course of the study, pregnant women excreted 69% more (vs. control; P < 0.001) 3-hydroxyisovaleric acid (3-HIA), a metabolite that accumulates during the catabolism of leucine when the activity of biotin-dependent methylcrotonyl–coenzyme A carboxylase is impaired. Interestingly, urinary excretion of 3-hydroxyisovaleryl-carnitine (3-HIA-carnitine), a downstream metabolite of 3-HIA, was 27% lower (P = 0.05) among pregnant (vs. control) women, a finding that may arise from carnitine inadequacy during gestation. No differences (P > 0.05) were detected in plasma biotin, urinary biotin, or urinary bisnorbiotin between pregnant and control women. Lactating women excreted 76% more (vs. control; P = 0.001) of the biotin catabolite bisnorbiotin, indicating that lactation accelerates biotin turnover and loss. Notably, with respect to control women, lactating women excreted 23% less (P = 0.04) urinary 3-HIA and 26% less (P = 0.05) urinary 3-HIA-carnitine, suggesting that lactation reduces leucine catabolism and that these metabolites may not be useful indicators of biotin status during lactation. Overall, these data demonstrate significant alterations in markers of biotin metabolism during pregnancy and lactation and suggest that biotin intakes exceeding current recommendations are needed to meet the demands of these reproductive states. This trial was registered at clinicaltrials.gov as NCT01127022. J. Nutr. doi: 10.3945/jn.114. 194472.
Absolutely Continuous Spectrum in the Anderson Model on the Bethe Lattice

We prove that the spectrum of the Anderson Hamiltonian Hλ = −∆ + λV on the Bethe Lattice is absolutely continuous inside the spectrum of the Laplacian, if the disorder λ is sufficiently small. More precisely, given any closed interval I contained in the interior of the spectrum of the (centered) Laplacian ∆ on the Bethe lattice, we prove that for small disorder, Hλ has purely absolutely continuous spectrum in I with probability one (i.e., σac(Hλ)∩ I = I and σpp(Hλ)∩ I = σsc(Hλ)∩ I = ∅ with probability one). The Bethe lattice (or Cayley tree), B, is an infinite connected graph with no closed loops and a fixed degree (number of nearest neighbors) at each vertex (site or point). The degree is called the coordination number and the connectivity, K, is one less the coordination number. The distance between two sites x and y will be denoted by d(x, y) and is equal to the length of the shortest path connecting x and y. The Anderson model on the Bethe lattice is given by the random Hamiltonian
Oncolytic Reovirus Activity Following Tumor Cell Infection by Killer Cell Interactions Induce Antitumor Natural - Reciprocal Human Dendritic Cell

Oncolytic virotherapy may mediate antitumor effects via direct oncolysis or immune-mediated tumor regression. Although the ability of oncolytic viruses to generate adaptive antitumor immunity has been characterized, their interactions with the innate immune system are relatively unclear. Using a human in vitro system, this study investigates the innate immunological consequences of reovirus therapy and its potential to activate NK cell-mediated antitumor activity. Dendritic cells (DC) loaded with reovirus-infected human melanoma Mel888 cells (DC-MelReo), but not reovirus-infected tumor cells alone, induced IFN- (cid:1) production within the NK cell population upon coculture with PBMC, in a cell-to-cell contact-dependent manner. DC-MelReo secreted the chemokines CCL2, 3, 4, 5, 7, 8, 11, and CXCL10; these culture supernatants induced NK cell chemotaxis. Coculture of DC-MelReo with puriﬁed NK cells induced reciprocal contact-dependent phenotypic DC maturation, while DC-MelReo elicited up-regulation of the activation marker CD69 on NK cells, in a partially contact and partially IL-12 dependent manner. Signiﬁcantly, DC-MelReo induced NK cell cytotoxicity toward tumor cells by a type I IFN dependent mechanism. These data demon-strate that tumor infection by reovirus can act via DC to induce NK cell recruitment, activation, and cytotoxicity, along with reciprocal DC maturation. These ﬁndings suggest that reciprocal DC-NK cell interactions, following reovirus therapy, may play an important role in altering the immune milieu of the
The 4 th International Conference on Ambient Systems , Networks and Technologies ( ANT-2013 ) Protocol for latency reduction of prioritized tra ffi c in WSN

In critical scenarios nodes switch from low data rate of transmission mode to high data rate. Such scenarios are event driven and traffic is highly dynamic in nature. Latency and reliability issues with Quality of Service (QoS) for such applications in IEEE 802.15. 4 have been an issue. The earlier schemes did address them but high data rates and channel error rates resulted in increase in contention for GTS request packets and increased data packet drop rate. In our work, we employed a mechanism to deal with isuues arising out of additional contention caused by prioritized nodes in CAP. We present an enhanced MAC scheme that incorporates two-level service differentiation through Contention Window Differentiation (CWD) and dynamic p-persistent CSMA, for mitigating the issues like lower transmission delays and higher success probability to time-critical messages in high channel error conditions. We evaluate our proposed scheme for varying channel and traffic-load conditions by simulation using Omnet++. The results show that performance in terms of the mentioned issues has improved significantly. Further, the energy decline rate analysis have been done for varying traffic arrival rates and compared with the original IEEE 802.15. 4 and found that our scheme has less energy decline rate thus increased network lifetime. c © 2011 Published by Elsevier Ltd. Selection and/or peer-review under responsibility of [name organizer]
Metabolism of a Glycosaminoglycan duringMetamorphosis in the Japanese Conger eel

1 Nanae Fresh Water Laboratory, Field Science Center of Northern Biosphere, Hokkaido University, Nanae, 041-1105 Hokkaido, Japan 2 Department of Fisheries, Graduate School of Agriculture, Kinki University, Nara, 631-8505 Nara, Japan 3 Nikko Station, National Research Institute of Fisheries Science, Fisheries Research Agency, Nikko, 321-1661 Tochigi, Japan 4 Nansei Station, National Research Institute of Aquaculture, Fisheries Research Agency, Minamiise, 516-0193 Mie, Japan 5 Hyogo Prefectural Fisheries Experimental Station, Akashi, 674-0093 Hyogo, Japan
International Conference in Knowledge Based and Intelligent Information and Engineering Systems-KES 2013 PageRank-Based Tra ffi c Simulation using Taxi Probe Data

Traffic analysis is an important work to transport people and goods to their destinations in a quick and efficient manner. In these years, probe taxis, which equip with some sensors (e.g., global positioning system), become widely used in Tokyo. Additionally, their sensor data enable us to predict the amount of future traffic. In this paper, we report a web-based viewer of taxi probe data which are used for traffic simulation. Moreover, we propose a traffic simulation model based on the concept of “PageRank”, which is used for the Google search engine, to gain a quick overview of traffic flow in Tokyo. The original algorithm of “PageRank” needs a matrix calculation called “Google matrix”, but the matrix calculation can be simulated by transitions of web surfers among web pages. Thus, we also assume the transitions of taxis as the same characteristics of the web surfers, and develop a traffic simulator to find important spots which have a strong effect on transportation efficiency. c © 2013 The Authors. Published by Elsevier B.V. Selection and peer-review under responsibility of KES International.
Differentiation-Associated Gene 5 by Upregulating TLR3 and Melanoma Induced Inflammatory Responses - Self-RNA Muscle Cells to Double-Stranded RNA- and Arteries and Cultured Coronary Smooth Primes Intact Human Coronary g IFN-and

Atherosclerosis of native coronary arteries and graft arteriosclerosis in transplanted hearts are characterized by activation ofinnate andadaptive immune responses. Nucleic acids generated byinfections orcell deathhave been detectedwithinarterioscleroticlesions, and it is known that microbial and synthetic nucleic acids evoke inﬂammatory responses in cultured vascular cells. In this study, we report that model RNA, but not DNA, instigated robust cytokine and chemokine production from intact human coronary arteries containing both intrinsic vascular cells and resident/inﬁltrating leukocytes. An ssRNA analog induced TNF- a and IFN- g –induced protein of 10 kDa secretion by isolated human PBMCs, but not vascular cells. Conversely, synthetic dsRNA induced these inﬂammatory mediators by vascular cells, but not PBMCs. IFN- g , a cytokine linked to atherosclerosis and graft arteriosclerosis, potentiated the inﬂammatory responses of intact arteries and cultured vascular smooth muscle cells (VSMCs) to polyinosinic: polycytidylic acid [poly(I:C)] and was necessary for inﬂammatory responses of VSMC to self-RNA derived from autologous cells. IFN- g also induced the expression of TLR3, melanoma differentiation-associated gene 5, and retinoic acid-inducible gene I dsRNA receptors. Small interfering RNA knockdown revealed that TLR3 mediated VSMC activation by poly(I:C), whereas melanoma differentiation-associated
Grading study quality in systematic reviews

ABSTRACT: There is a growing need for the development of a research base in stammering intervention research. Systematic review is one among a number of tools that can be used. The key to a useful systematic review is the use of explicit quality criteria. This article discusses the application of the Oxford Centre for Evidence-based Medicine levels of evidence to the field of stammering and tests it by applying it to two recent articles (M. Jones et al., 2005 and M. C. Franken, K. van der Schalk, and H. Boelens, 2005).
Drinking with parents

Aims: Is drinking with parents (DWP) likely to curb or to encourage adolescent heavy drinking? The scant number of studies addressing this issue have arrived at contradictory conclusions, which may reflect that different measures of DWP have been used. We pursued the assumption, taking potential confounding related to parental alcohol-specific rule-setting and parenting style into account. Method: Data stem from the Norwegian 2015 ESPAD survey of 15–16 year olds. Drinking with parents at the last drinking event and the frequency of DWP in the past year were assessed among those who had consumed alcohol (n = 1374). Severe drunkenness and binge drinking in the past month were the outcomes. Parental covariates were accounted for in Poisson regression models. Results: One in five (21%) had been drinking with their parents the last time they consumed alcohol, and this DWP measure was strongly and inversely related to both drunkenness and binge drinking. Adolescents who reported no DWP episodes in the past year (61%) and those who reported 1–2 such episodes (30%) barely differed with respect to the two outcomes. More frequent DWP (9%) was significantly associated with an increased risk of heavy episodic drinking, but the statistical impact on severe drunkenness was no longer significant when adjusting for parental covariates. Conclusions: Different measures of DWP were related differently to adolescent heavy drinking, indicating that studies based on DWP at the last drinking event are biased in favour of the view that adolescents may “learn” sensible drinking by consuming alcohol with their parents.
Cancers among HIV Infected Patients : A Reason for Routine Screening

Human immunodeficiency virus (HIV) has been associated with increased risk of cancer worldwide (1) . Despite the proven efficacy of HAART, Death associated with cancer among the HIV infected has therefore remained a big challenge. (2) Cancer screening is a proven effective method of prevention and control in many populations. (16) We analyzed the type of cancers HIV infected patients presented with at some treatment facilities with a view to sensitize health worker to the need for routine cancer screening among HIV infected persons. This is a prospective data collection of HIV infected patients at two major treatment facilities in Plateau state over a three year period January 2013 to January 2016. A total of 343 participants were enrolled, 184(56.4%) males and 159(46.4%) females. Majority of reponndants 100(29.1%) were in the age group 37 47years, 83.4%(286) were married and 244(31.1%) were unemployed. About 121(35.48%)95% of participants CI: 30.45-40.85 had up to primary school education while 20(8.5%) had no formal education at all CI: 5.86-12.11. The commonest malignancy found among respondents is Kaposi sarcoma 129(37.6%), followed by breast cancer49(14.3%), prostate29(8.7%) and colorectal cancer24(7%). Cervical cancer and Non Hodgkin's lymphoma were at 16(4.5%) and 13(3.8%) respectively. Non AIDS defining cancer is on the increase among HIV infected persons in our community. There is therefore urgent need for routine screening and early detection of cancer among our infected patients.
Information on Corporate Social Responsibility and SME´s Environmental Responsiveness: A Regional Study

The theoretical framework of market orientation from Kholi and Jaworski (1990), and the extended concept of market considering all agents of interest, has served as background for analysing the relationship between the three sub-dimensions of what we call orientation to environmental responsibility: information on CSR (Corporate Social Responsibility), the disclosure that the company itself makes of its CSR, and the organizations environmental responsiveness. The analysis is based on the perceptions of managers of a large sample of small companies (758 in the Autonomous Community of Extremadura in Spain). It was empirically demonstrated with the methodology of structural equations, that the greater concern about the CSR issues corresponds to the higher engagement in the dissemination of CSR outcomes and consequently, managers increase their predisposition to respond favourably to environmental demands of society.
Suraksha: A Security Designers' Workbench

To design a secure software system, a security designer needs a workbench so that security of the system can be embedded into the system from the very early stages of Software Development Life Cycle (SDLC). Among the proposed approaches to elicit security aspects in the early stages of SDLC, researchers have suggested different techniques. However, a workbench that will facilitate a designer to build security right from the requirement analysis is not available. This paper presents a Security Designers' Workbench to achieve this.
Grocery Retailing in India: Online Mode versus Retail Store Purchase

E-retailing is entering into the Indian retail scenario in a noticeable way and online grocery retailing holds a promise of acceptance by the Indian customers. This paper attempts to discover the market potential of online grocery retailing in India and consumers’ perception towards its different aspects. Confirmatory factor analysis proposes that there are five underlying dimensions (convenience, value for money, variety, loyalty and ambient factors) governing the selection of mode for grocery purchase. Thereafter Binary-Logistic Regression has been employed to analyze the impact of these five broad perceptual dimensions upon the acceptance/rejection of online grocery retailing. The respondents accorded the highest importance to the factors value for money and convenience. The study suggested that issues like meeting customer expectations and preferences in terms of delivering value for money, quick and convenient purchasing, smooth delivery process, and reducing risk perceptions are critical for establishing online grocery retailing as an effective alternative to traditional brick and mortar retailing.
Effect of Composite Preparation Techniques on Electrical and Mechanical Properties and Morphology of Nylon 6 Based Conductive Polymer Composites

Nylon 6/carbon black conductive compos- ites were prepared using two different methods, master- batch dilution and melt mixing. Their effect on the size and distribution of carbon black agglomerates in the ma- trix was studied in terms of electrical and mechanical properties and morphology. The electrical resistivity of composites prepared by both methods decreased with increasing filler composition. The electrical resistivity of the diluted masterbatch composites and the melt mixed composites was reduced from the resistivity of pure nylon 6, 10 15 ''ohm, cm'', to 10 7 ''ohm, cm'' at 1 and 6 wt % of car- bon black, respectively. As the filler content increased, elongation at break and impact strength decreased, but tensile modulus increased. Masterbatch dilution method provided smaller carbon black clusters in composites com- pared to melt mixing method. 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 2520-2526, 2006
Prostaglandins and Other Lipid Mediators eview yelin , DIGs , and membrane rafts in the central nervous system

Over the past 40 years our understanding of the organization of cell membranes has changed dramatically. Membranes are no longer viewed as a homogenous sea of phospholipids studded with randomly positioned islands of proteins. Our current view of the membrane involves the formation of small lipid clusters, comprised mainly of cholesterol and sphingolipids, known as membrane rafts. These lipid clusters apparently include and exclude specific proteins leading to the hypothesis that these domains (1) regulate cellular polarity and compartmentalization through trafficking and sorting, (2) provide platforms for cellular signaling and adhesion, and (3) function as cellular gate keepers. Tremendous controversy surrounds
Self-efficacy; the strongest predictor of academic involvement in high school students

Lack of school engagement among adolescents in Iran remains a problem that can have serious consequences consists of raised risk for school dropout, substance use and criminal activity. Evidently, identification of psychological variables (parents and self variables), may help adolescents to improve their academic performance. The present study examined predictors of academic involvement in Kerman. Participants were 1200 high school students aged between 12 -18 years old. The results of Hierarchical regression indicated that the strongest predictor of academic involvement is academic self-efficacy.
Measuring and Modelling the Market Liquidity of Stocks: Methods and Issues

The liquidity of an asset in modern financial markets is a key and, yet, elusive concept. A market is often said to be liquid when the prevailing structure of transactions provides a prompt and secure link between the demand and supply of assets, thus delivering low costs of transaction. Providing a rigorous and empirically relevant definition of market liquidity has, however, provided to be a difficult task. This paper provides a critical review of the frameworks currently available for modelling and estimating the market liquidity of stocks. We discuss definitions of market liquidity that stress the role of the bid-ask spread and the estimation of its components arising from alternative sources of market friction. In this case, measures of liquidity based on intra-daily data are relevant for capturing the core features of a market, and for their ability to account for the arrival of new information.
The genus Leptoxyphium ( Capnodiaceae ) from China

Leptoxyphium is a relatively poorly known genus of sooty moulds in Capnodiaceae (Dothideomycetes). This paper introduces one new species of Leptoxyphium , L . glochidion and the first record of L. kurandae for China. L . glochidion is introduced as a new species based on morphology and molecular data and is compared with related taxa. Descriptions, illustrations and notes are provided for the two species, which are analyzed by ITS, LSU and SSU sequence data. The phylogenetic analysis shows that the two species cluster in Leptoxyphium (Capnodiaceae). L. glochidion separates from other species of the genus, while L. kurandae clustered with the type strain
Tactile sensing arrays - design and processing

Tactile sensing is probably the second most important,most complex perception of the human body after thevision. The human skin is filled with tiny mechanorecep-tors that separate different components of tactile input(static pressure, motion, vibration, etc.) into parallel chan-nels, and send them to the central processing unit, thebrain. Our final goal is to mimic the operation of this sens ing-processing system with artificial tactile sensors that couldbe integrated into robotic hands, medical diagnostic de-vices or even into e.g. arm prostheses to improve theirefficiency.The core element of our research is a three-axial forcesensing array, developed by the Research Institute forTechnical Physics and Materials Science (MFA). This tinyMEMS (Micro-Electro-Mechanical System) device is asingle-crystalline Si-based sensor that – unlike the com-mercial tactile sensory arrays – measures and processesnot only the normal, but also shear components of theforce vectors at its surface.The elastic cover is an indispensable key componentof the tactile sensors. Besides offering a certain amountof physical protection, it also plays a fundamental rolein the overall procedure of sensation as a mechanicalinformation-coding layer between the sensors and theenvironment (let us just think about the increased tac-tile sensitivity around an abrasion, or our thickening soleduring summer holidays). The elastic cover can be treat-ed as the