Miracle-dz/UniFAR-FTUs huggingface dataset:
Transcytose à travers la barrière hémato-encéphalique : étude in vitro du transport des lipoproteines de basse densité et du peptide ß-amyloïde

La Barriere Hemato-Encephalique (BHE) est une interface localisee au niveau des cellules endotheliales des capillaires cerebraux (CECs). Elle presente des caracteristiques structurales et metaboliques specifiques restreignant considerablement les echanges entre le sang et le cerveau dans le but de maintenir l’homeostasie du systeme nerveux central (SNC). La presence de transporteurs et recepteurs au niveau de CECs permet l’apport de nutriments essentiels au fonctionnement cerebral. L’expression de ces proprietes est induite par l’environnement cerebral et notamment par la population astrocytaire. Dans notre laboratoire, la BHE est reconstituee in vitro en co-cultivant des CECs bovines et des cellules gliales primaires de rat reproduisant les principales caracteristiques de la BHE in vivo. Son utilisation a permis de mettre en evidence une voie originale de transcytose (recepteur-dependante) assurant le transport des lipoproteines de basse densite (LDL) vers le parenchyme cerebral. Nous avons caracterise les premieres etapes de ce processus et demontre que celles-ci impliquent des structures cellulaires specialisees comme les caveoles et les caveosomes, permettant aux lipoproteines d’etre relarguees intactes vers le compartiment cerebral. Recemment, de nombreux travaux ont place la BHE au centre des echanges des peptides β-amyloide (Aβ) entre le sang et le cerveau. Un defaut des mecanismes de transport est suspecte d’etre a l’origine de l’accumulation cerebrale de ces peptides responsables de la maladie d’Alzheimer (MA). En utilisant notre modele in vitro de BHE, nous avons etudie l’implication des CECs dans les echanges de ces peptides. Nous avons demontre l’implication du recepteur « receptor for advanced glycation end-products » (RAGE) dans l’entree vers le compartiment cerebral des peptides Aβ. Ce transport est specifique et implique la voie des caveoles. L’implication de pompes d’efflux telles que la P-glycoproteine (P-gp) et la « breast cancer resistance protein » (BCRP) dans la restriction de l’influx des peptides Aβ a egalement ete mise en evidence. D’autre part, des resultats preliminaires suggerent que le recepteur « low density lipoprotein receptor-related 1 » (LRP1) n’est pas implique dans l’efflux des peptides Aβ. Ces resultats contribuent a apporter une meilleure comprehension du role de la BHE dans la MA et permettent d’envisager de nouvelles approches therapeutiques.
Probabilistic M/EEG source imaging from sparse spatio-temporal event structure

While MEG and EEG source imaging methods have to tackle a severely ill-posed problem their success can be stated as their ability to constrain the solutions using appropriate priors. In this paper we propose a hierarchical Bayesian model facilitating spatio-temporal pat-terns through the use of both spatial and temporal basis functions. We demonstrate the eﬃcacy of the model on both artiﬁcial data and real EEG data.
PENGARUH STRUKTUR KEPEMILIKAN DAN STRUKTUR MODAL TERHADAP KEBIJAKAN INISIASI DIVIDEN DI INDONESIA

This article is intended at elaborating research investigating the effects of ownership structure to dividend initiation policy among Indonesian going-public firms. The research was conducted to sample consisting of 180 going-public firms listed in Jakarta Stock Exchange and selected purposively based on criteria that such firms conducted initial public offering (IPO) during the time range of 1989–2000. All data needed was categorized as secondary data comprising of financial data. Using Structural Equation Model to analyze data, this research finds no significant evidence supporting hypothesis that ownership structure affects dividend initiation policy among going public firms. The finding fails to provide support to theoretical prediction of monitoring mechanism as part of agency cost model of dividend explanation. Consequently, the model, as one of the main explanation models of dividend under relevance of dividend proposition, does not fully hold in explaining dividend initiation policy behavior in Indonesian goingpublic firms.
A Three-Question Framework to Facilitate Clinical Decision Making

Context: Highly developed critical thinking and the ability to discriminate among many possible therapeutic interventions is a core behavior for the practicing athletic trainer. However, while athletic training students receive a great deal of clinically applicable information, many are not explicitly trained in efficient methods for channeling this great volume of data into sound clinical decisions. Objective: To propose a simple, three-question framework for prudent clinical decision making in therapeutic modalities and rehabilitation contexts. Background: Athletic training education occurs in various settings, where students are immersed in basic cognitive and psychomotor proficiencies germane to the prevention, evaluation, treatment, and rehabilitation of injury and illness in the physically active. In clinical practice, the knowledge and demonstration of these proficiencies are vital to the development of sound clinical decision making. Description: I propose a simple and repeatable three-question de.
Spiral CT in diagnosis and treatment of femoral neck fractures

ObjectiveTo investigate the value of spiral CT in diagnosis and treatment of femoral neck fractures.MethodsFrom December 2008 to February 2010, 192 cases of femoral neck fractures were examined first by X-ray and next by spiral CT scanning plus three-dimensional reconstruction. They were 90 men and 102 women, aged from 18 to 89 years (average, 71.2 years) . The differences of the 2 examinations were compared.ResultsThe diagnostic rate of X-ray was 95.8％(184/192), significantly lower than that of spiral CT [100％ ( 192 / 192 )] (x2 =6. 255, P =0. 012). Four fractures were shown as incomplete on X-ray films, but demonstrated as complete on CT images. Spiral CT three-dimensional reconstruction demonstrated rotated displacement and rotation direction of the femoral head in 75 cases while X-ray only showed rotated displacement in 10 cases without demonstration of the rotation direction. Bone chips in 47. 9％(92/192) of the patients were demonstrated by spiral CT, significantly higher than those by X-ray [12.5％ (24/192)] (x2=57. 116, P=0. 000) . Correct fracture typing by X-ray was 73.4％ (58/79),significantly lower than that by spiral CT 100％ (79/79)(x2 =24. 219, P =0. 000). According to Spiral CT results, treatment protocols were adjusted for 31 patients.ConclusionIn diagnosis and treatment of femoral neck fractures, spiral CT is more valuable than X-ray because it can demonstrate three-dimensional details of a specific fracture. Key words: Femoral neck fractures; Tomography, spiral computed; Diagnosis; Therapy
Polarization resolved four-wave mixing microscopy: structural and vibrational read-out in molecular media

One of the greatest challenges in nonlinear optics microscopy is the search for new contrast mechanisms. This is one of the reasons of the increasing interest in polarimetric nonlinear optics in the last couple of decades. In this work we have explored the potential of four-wave mixing in probing vibrational and structural symmetries in molecular media. In particular, we have been concerned with coherent Raman scattering (CRS), either at resonance or not. We have developed a theoretical model allowing to determine the structures of the susceptibility tensors from symmetry considerations, involving both the spatial structure of the medium and the vibration of specific molecular modes. Experimental results on isotropic sample, crystals and biomolecular assemblies were successfully achieved. Polarimetric measurements at resonance provide information on the symmetry of the addressed vibrational modes and on departure from Kleinman symmetry conditions. Nonresonant polarimetric measurements are able to reveal departure from isotropy in cubic crystals and the symmetry order and orientation of molecular distribution in biomolecular assemblies, such as collagen fibers. In particular, we have shown that higher-order molecular symmetries can only be probed by high-order nonlinear optical processes. Finally, this work has demonstrated the great potential of polarimetric four-wave mixing as a powerful contrast mechanism, providing structural selectivity in microscopy imaging. When it is further associated with a resonant process (such as CRS), it provides also chemical selectivity, allowing a complete description of the sample, involving both structural and vibrational symmetries.
Femtochemistry: Ultrafast Dynamics of the Chemical Bond

These two volumes on Femtochemistry present a timely contribution to a field central to the understanding of the dynamics of the chemical bond. This century has witnessed great strides in time and space resolutions, down to the atomic scale, providing chemists, biologists and physicists with unprecedented opportunities for seeing microscopic structures and dynamics. Femtochemistry is concerned with the time resolution of the most elementary motions of atoms during chemical change - bond breaking and bond making - on the femtosecond (10-15 second) time scale. This atomic scale of time resolution has now reached the ultimate for the chemical bond and as Lord George Porter puts it, chemists are near the end of the race against time. These two volumes cover the general concepts, techniques and applications of femtochemistry.Professor Ahmed Zewail, who has made the pioneering contributions in this field, has from over 250 publications selected the articles for this anthology. These volumes begin with a commentary and a historical chronology of the milestones. He then presents a broad perspective of the current state of knowledge in femtochemistry by researchers around the world and discusses possible new directions. In the words of a colleague, ';it is a must on the reading-list for all of my students . ; all readers will find this to be an informative and valuable overview. ';The introductory articles in Volume I provide reviews for both the non-experts as well as for experts in the field. This is followed by papers on the basic concepts. For applications, elementary reactions are studied first and then complex reactions. Volume I is complete with studies of solvation dynamics, non-reactive systems, ultrafast electron diffraction and the control of chemical reactions.Volume II continues with reaction rates, the concept of elementary intramolecular vibrational-energy redistribution (IVR) and the phenomena of rotational coherence which has become a powerful tool for the determination of molecular structure via time resolution. The second volume ends with an extensive list of references, according to topics, based on work by Professor Zewail and his group at Caltech.These collected works by Professor Zewail will certainly be indispensable to both experts and beginners in the field. The author is known for his clarity and for his creative and systematic contributions. These volumes will be of interest and should prove useful to chemists, biologists and physicists. As noted by Professor J Manz (Berlin) and Professor A W Castleman, Jr. (Penn State): femtochemistry is yielding exciting new discoveries from analysis to control of chemical reactions, with applications in many domains of chemistry and related fields, e.g., physical, organic and inorganic chemistry, surface science, molecular biology, . etc.
Ultrashort laser pulses : generation and applications

Generation of ultrashort optical pulses. - Optical nonlinearities with ultrashort pulses. - Ultrashort interactions in solids. - Ultrafast Optoelectronics. - Ultrafast coherent spectroscopy. - Ultrashort intramolecular and intermolecular vibrational energy transfer of polyatomic molecules in liquids. - Ultrafast chemical reactions in the liquid state. - Biological processes studied by ultrafast laser techniques. - Addendum A: Generation of ultrashort optical pulses. - Addendum B: Optical nonlinearities with ultrashort pulses. - Addendum C: Ultrashort interactions in solids. - Addendum D: Ultrafast optoelectronics. - Addendum E: Ultrafast coherent spectroscopy. - Addendum F: Ultrashort intramolecular and intermolecular vibrational energy transfer of polyatomic molecules in liquids. - Addendum G: Ultrafast chemical reactions in the liquid state. - Addendum H: Biological processes studied by ultrafast laser techniques, an update of chapter 9.
Comprehensive heterocyclic chemistry II : a review of the literature, 1982-1995 : the structure, reactions, synthesis, and uses of heterocyclic compounds

Hardbound. Since its publication in 1984, Comprehensive Heterocyclic Chemistry (CHEC) has become the standard work on the subject, indispensable to all serious readers in the multitudinous areas where heterocycles are employed. Comprehensive Heterocyclic Chemistry II has two major aims: to report in the enormous advances in the subject of the last decade and to extend the coverage into areas where CHEC left significant gaps. The latter includes particularly saturated and partially saturated compounds, rings containing less common heteroatoms, and many classes of bicyclic and polycyclic systems. Material included in CHEC is, for the most part, not repeated in CHEC II and the two works are designed to be used together.
RHEOLOGIE DES BITUMES - METHODES DE MESURE, RELATIONS ENTRE LA COMPOSITION ET LA RHEOLOGIE

Les methodes de mesure des proprietes rheologiques par des essais mecaniques, fluage, relaxation, essais a vitesse imposee, module complexe, viscosite sont exposees. L'exploitation des resultats de ces mesures permet a partir des courbes isothermes d'evaluer la susceptibilite dynamique a une temperature donnee et a partir des isochrones (frequence donnee) d'apprecier la susceptibilite thermique. Le cas des bitumes, des elastomeres, des bitumes polymeres sont presentes. Les relations entre composition, structure et proprietes rheologiques sont ensuite etudiees ainsi que l'influence des caracteristiques des liants sur les proprietes mecaniques des revetements, enrobes ou enduits. (Voir fiche generale DIRR 130969).
Nanostructures plasmoniques dynamiques assemblées sur ADN

Nous montrons comment des dimeres de nanoparticules d'or, assembles sur un brin d'ADN unique presentant un site de reconnaissance specifique, fournissent une reponse optique macroscopique dependant de leur environnement chimiqueLa separation electrophoretique nous permet de preparer des suspensions purifiees de dimeres de nanoparticules d'or de diametre allant de 8 a 60 nm, et possedant differentes chimies de surface, avec une purete pouvant atteindre 90%. L'echafaudage d'ADN contient une structure tige-boucle permettant de modifier reversiblement la structure du dimere en presence d'un brin d'ADN cible. Les distances interparticules (D), estimees en TEM cryogenique, peuvent varier de facon reversible jusqu'a un facteur 3 pour des spheres d'or de 8 nm de diametre.Afin de traduire le changement conformationnel de l'echafaudage d'ADN en un signal optique mesurable, nous mesurons les spectres de diffusion de dimeres uniques de nanoparticules d'or de 40 ou 60 nm de diametre, en chambre microfluidique.Nous avons pu, en augmentant la concentration saline locale, diminuer progressivement D a l'echelle nanometrique, de 20 a 1 nm, ce qui se traduit par un decalage spectral de la resonance vers le rouge. La bonne correlation entre les reponses spectrales de dimeres uniques, estimees avec un spectrometre ou une camera CCD couleur, nous permet de demontrer une methode de detection en champ large et a bas cout, de la deformation nanometrique de ces nanostructures. L'utilisation de ligands amphiphiles nous a permis d'optimiser la stabilite colloidale des dimeres de particules d'or pour minimiser leur sensibilite a la force ionique locale et aux changements de temperature.
Natural language processing and information systems : 16th International Conference on Applications of Natural Language to Information Systems, NLDB 2011, Alicante, Spain, June 28-30, 2011 : proceedings

This book constitutes the refereed proceedings of the 16th International Conference on Applications of Natural Language to Information Systems, held in Alicante, Spain, in June 2011. The 11 revised full papers and 11 revised short papers presented together with 23 poster papers, 1 invited talk and 6 papers of the NLDB 2011 doctoral symposium were carefully reviewed and selected from 74 submissions. The papers address all aspects of Natural Language Processing related areas and present current research on topics such as natural language in conceptual modeling, NL interfaces for data base querying/retrieval, NL-based integration of systems, large-scale online linguistic resources, applications of computational linguistics in information systems, management of textual databases NL on data warehouses and data mining, NLP applications, as well as NL and ubiquitous computing.
Prediction of gas chromatographic separation for PBDE congeners from molecular descriptors

Polybrominated diphenyl ethers (PBDE) have been identified as environmental contaminants with a widespread distribution. The separation properties of PBDEs in high-resolution gas chromatography (HRGC) are important both for environmental analysis and for determining physical properties such as the vapour pressures. This study reports a quantitative structure-property relationship (QSPR), established between relative retention times on capillary HRGC and two constitutional structure descriptors that can perform equally well as more elaborate approaches. The simplified approach is recommended for explanatory models, while a more in-depth multivariate characterisation is suggested to assure similarity in applying prediction models.
Characterization of natural zeolite membranes for H2/CO2 separations by single gas permeation

Natural zeolite membranes can be used as a model for the development of robust molecular sieve membranes with superior separation characteristics. We describe the characterization of natural clinoptilolite membranes made from dense mineral deposits by single gas H 2 and CO 2 permeation. Permeability values as a function of temperature and pressure were analyzed on the basis of mass transport fundamentals of gas permeation through zeolite and nonzeolite pathways. H 2 and CO 2 fluxes through the membranes were fitted with a model based on a combination of zeolitic, Knudsen, and viscous transports so that the selective and nonselective flux fractions could be quantified. An increase in feed pressure increased the total permeance especially at low temperatures. The membranes were also characterized by XRD, SEM, and EDX analysis.
Comparative effects of new generation oxazaphosphorines on the size and viability of human acute myeloblastic leukemia cells.

The risk of infections of human recipients after xenotransplantations is now mainly represented by porcine endogenous retroviruses (PERVs) as these particles are part of the porcine genome. As in all vertebrates, human genome harbours its own numerous genetic sequences of retroviral origin; it is estimated that they comprise about 8 % of the human genome. Because some of them play an important role in human physiology, it is valuable to estimate whether the presence of PERVs in human cells influences homeostasis of the human endogenous retrovirus (HERV) expression pattern. The aim of the study was to evaluate whether the expression profile of HERV-W genes changes after infection of cells by porcine endogenous retroviruses. In the experimental settings, human embryonic kidney cell line (HEK-293) was infected by PERV particles and cultivated up to 22th passage after infection. HERV-W gag, pol and env, as well as env from locus 7q21.2 gene expression was monitored by means of realtime reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and Western blot techniques. We found that the expression level of HERV-W genes differs in PERV-infected HEK-293 cell cultures in comparison with that from non-infected cultures. Relative HERV-W gene expression also differed significantly between particular passages (P < 0.05). Moreover, we have noticed a high correlation between the HERV-W Env(7q21.2) mRNA and protein level (Spearman rank r = 0.65; P < 0.05) during the course of the experiment. As previously hypothesized, human genomic sequences of retroviral origin may be changed by the presence of porcine endogenous retroviruses.
Innovative bio-products for agriculture

Abstract The paper reports state of the art research in the field of novel bio-based products for agriculture. Biopesticides, biostimulants and biofertilizers were shown as a potential alternative or additional products to the currently used agrochemicals. The present situation on the market of agrochemicals was discussed. Difficulties related to products registration were taken into account. Research on supercritical algal extracts as a biostimulant of plant growth and health supporting feed additive for laying hens was presented, as well as the perspectives of the use of biomass as the carrier of fertilizer nutrients. The method of production of new fertilizer components with micronutrients was biosorption. The concept of new phosphorus biofertilizers containing living microflora that solubilizes phosphorus was reported. Graphical Abstract
Optimization in computational chemistry and molecular biology : local and global approaches

Preface. Predicting Protein Tertiary Structure using a Global Optimization Algorithm with Smoothing A. Azmi, et al. Methodology for Elucidating the Folding Dynamics of Peptides: Met-enkephalin Case Study J.L. Klepeis, C.A. Floudas. Energy Landscape Projections of Molecular Potential Functions A.T. Phillips, et al. Global Optimization and Sampling in the Context of Tertiary Structure Prediction: A Comparison of Two Algorithms V.A. Eyrich, et al. Protein Folding Simulations by Monte Carlo Simulated Annealing and Multicanonical Algorithm Y. Okamoto. Thermodynamics of Protein Folding - The Generalized-Ensemble Approach U.H. E. Hansmann. An approach to detect the dominant folds of proteinlike heteropolymers from the statistics of a homopolymeric chain E.D. Nelson, et al. Gene Sequences are Locally Optimized for Global mRNA Folding W. Seffens, D. Digby. Structure Calculations of Symmetric Dimers using Molecular Dynamics/Simulated Annealing and NMR Restraints: The Case of the RIIalpha Subunit of Protein Kinase A D. Morikis, et al. Structure Prediction of Binding States of MHC Class II Molecules based on the Crystal of HLA-DRB1 and Global Optimization M.G. Ierapetritou, et al. A Coupled Scanning and Optimization Scheme for Analyzing Molecular Interactions J.C. Mitchell, et al. Improved Evolutionary Hybrids for Flexible Ligand Docking in AutoDock W.E. Hart, et al. Electrostatic Optimization in Ligand Complementarity and Design E. Kangas, B. Tidor. Exploring potential solvation sites of proteins by multistart local minimization S. Dennis, et al. On relative position of two biopolymer molecules minimizing the weighted sum of interatomic distances squared A.B. Bogatyrev. Visualization of Chemical Databases Using the Singular Value Decomposition and Truncated-Newton Minimization D. Xie, T. Schlick. Optimization of Carbon and Silicon Cluster Geometry for Tersoff Potential using Differential Evolution M.M. Ali, A. Torn. D.C. Programming Approach for Large-Scale Molecular Optimization via the General Distance Geometry Problem L.T. H. An, P.D. Tao.