Miracle-dz/UniFAR-FTUs huggingface dataset:
Basis Light-Front Quantization Approach to Positronium

We present the first application of the recently developed Basis Light-Front Quantization (BLFQ) method to self-bound systems in quantum field theory, using the positronium system as a test case. Within the BLFQ framework, we develop a two-body effective interaction, operating only in the lowest Fock sector, that implements photon exchange, neglecting fermion self-energy effects. We then solve for the mass spectrum of this interaction. The resulting spectrum is compared to the expected Bohr spectrum of non-relativistic quantum mechanics. We examine in detail the dependence of the results on the infrared and ultraviolet cutoffs of the theory.
Application of Artificial Intelligence-Machine Learning in Dementia

Neuroimaging, body fluid biomarkers, genetic or proteomic data can detect dementia spectrum, both mild cognitive impairment and dementia, from normal ageing. With the advance technology, Artificial Intelligence (AI) displays encouraging results in supporting with recognition of early-stage dementia. By now AI and Machine Learning (ML) have advanced neuroimage analysis. Though, integration of heterogeneous biological data from different modalities into clinical practice is not quite there yet.
modelling to determine

Recent studies have shown that mechanical stimulation, by means of flow perfusion and mechanical compression (or stretching) enhances osteogenic differentiation of MSCs and bone cells within biomaterial scaffolds in vitro . However the precise mechanisms by which such stimulation enhances bone regeneration is not yet fully understood. Previous computational studies have sought to charaterise the mechanical stimulation on cells within biomaterial scaffolds using either computational fluid dynamics (CFD) or finite element (FE) approaches. However the physical environment within a scaffold under perfusion is extremely complex, and requires a multiscale and multiphysics approach to study the mechanical stimulation of cells. In this study, we seek to determine the mechanical stimulation of osteoblasts seeded in a biomaterial scaffold under flow perfusion and mechanical compression using multiscale modelling by two-way fluid structure interaction (FSI) and FE approaches. The mechanical stimulation, in terms of wall shear stress (WSS) and strain in osteoblasts, is quantified at different locations within the scaffold for cells of different attachment morphologies (attached, bridged). The results show that 75.4% of scaffold surface has a WSS of 0.1mPa - 10mPa, which indicates the likelihood of bone cell differentiation at these locations. For attached and bridged osteoblasts, the maximum strains are 397µε and 177,200µε, respectively. Additionally, the results from mechanical compression show that attached cells are more stimulated (maximum strain=22,600µε) than bridged cells (maximum strain=10,000µε). Such information is important for understanding the biological response of osteoblasts under in vitro stimulation. Finally, a combination of perfusion and compression of a TE scaffold is suggest for osteogenic differentiation. cells in TE scaffold under mechanical compression. The WSS, fluid velocity
Emergent probability ﬂuxes in conﬁned microbial navigation

When the motion of a motile cell is observed closely, it appears erratic, and yet the combination of nonequilibrium forces and surfaces can produce striking examples of organization in micro- bial systems. While most of our current understanding is based on bulk systems or idealized geometries, it remains elusive how and at which length scale self-organization emerges in complex geometries. Here, using experiments and analytical and numerical calculations, we study the motion of motile cells under controlled microﬂuidic conditions and demonstrate that probability ﬂux loops organize active motion, even at the level of a single cell exploring an isolated compartment of nontrivial geometry. By accounting for the interplay of activity and interfacial forces, we ﬁnd that the boundary’s curvature determines the nonequilibrium probability ﬂuxes of the motion. We theoretically predict a univer-sal relation between ﬂuxes and global geometric properties that is directly conﬁrmed by experiments. Our ﬁndings open the possi-bility to decipher the most probable trajectories of motile cells and may enable the design of geometries guiding their time-averaged motion.
DOES POVERTY AFFECT THE SOCIO-ECONOMIC DEVELOPMENT OF SCHEDULED CASTE HIGHER SECONDARY STUDENTS

: The socio-economic status of an individual or a community is influenced by multiple factors. This study attempts to find out whether the factor „poverty‟ affects the socio-economic development of scheduled caste higher secondary students.Survey method was adopted for the study. Simple random sampling technique was used for collecting a sample of 715 higher secondary students from 79 schools in Kanyakumari district of Tamil NaduState, India. The applied statistical techniques percentage analysis,„t‟ test, ANOVA, Pearson‟s product moment correlation, regression analysis and factor analysis revealed the following results. The level of poverty of majority of the SC higher secondary students was found to be moderate. A significant difference was found between male and female SC higher secondary students in their poverty, and the female SC higher secondary students were better than the male SC higher secondary students in their poverty. A significant difference was found among government, aided and private school SC higher secondary students in their poverty. The private school SC higher secondary students were better in their poverty than the aided school and government school SC higher secondary students. A significant relationship and influence were found between poverty and socio-economic status of SChigher secondary students. The factor analysis of the correlation matrix for poverty on socio-economic status of SC higher secondary students shows the presence of poverty with considerable factor loading. scheduled caste higher secondary
Rho is Required for the Initiation of Calcium Signaling and Phagocytosis by Fc (cid:103) Receptors in Macrophages

upon transfection of the Fc (cid:103) RIIA receptor. Rho was found to be essential for the accumulation of phosphotyrosine and of F-actin around phagocytic cups and for Fc (cid:103) receptor–mediated Ca 2 (cid:49) signaling. The clustering of receptors in response to opsonin, an essential step in Fc (cid:103) -induced signaling, was the earliest event shown to be inhibited by C3 exotoxin. The effect of the toxin was specific, since clustering and internalization of transferrin receptors were unaffected by microinjection of C3. These data identify a role for small GTPases in Fc (cid:103) receptor–mediated phagocytosis by leukocytes.
University of Testing a self-determination theory-based process model of physical activity behavior change in rheumatoid arthritis

Physical inactivity is prevalent in rheumatoid arthritis (RA) patients, increasing the risk of poor physical health and compromised well-being. Interventions are therefore required to support physical activity (PA) behavior change in this population. This study examined whether a self-determination theory (SDT) based exercise intervention for people with RA, increased autonomous motivation for PA and in turn, moderate-to-vigorous PA (MVPA) and subjective vitality RA patients (n = 115) were randomized to a 3-month SDT-based psychological intervention + RA-tailored exercise program (experimental group, n = 59) or a RA-tailored exercise program only (control group, n = 56). During the program, the SDT- based intervention group received one-on-one consultations with a PA advisor trained in delivering strategies to promote autonomous motivation for PA. Well-established questionnaires assessed autonomous and controlled motivation for PA, MVPA (min/week), and subjective vitality at baseline (T1) and 3 months (T2). Path analysis examined the hypothesized theoretical process model. The model demonstrated an excellent fit to the data ( n = 70, χ 2 (26) = 28.69, p = . 33, comparative fit index = 0.99, root square mean error of approximation = 0.04). The intervention corresponded to higher autonomous motivation and lower controlled motivation for PA at T2, after controlling for T1 autonomous and controlled motivation. In turn, changes in autonomous motivation from T1 to T2 significantly positively predicted changes in MVPA and subjective vitality. Results suggest an SDT based psychological intervention comprising autonomy-supportive strategies for PA predicted greater reported autonomous reasons for PA in RA patients participating in a tailored 3-month exercise program. Increased autonomous motivation linked to increased engagement in MVPA and feelings of vitality in these patients.
3-D Fabry–Pérot cavities sculpted on fiber tips using a multiphoton polymerization process

This paper presents 3D Fabry–Pérot (FP) cavities fabricated directly onto cleaved ends of low-loss optical fibers by a two-photon polymerization (2PP) process. This fabrication technique is quick, simple, and inexpensive compared to planar microfabrication processes, which enables rapid prototyping and the ability to adapt to new requirements. These devices also utilize true 3D design freedom, facilitating the realization of microscale optical elements with challenging geometries. Three different device types were fabricated and evaluated: an unreleased single-cavity device, a released dual-cavity device, and a released hemispherical mirror dual-cavity device. Each iteration improved the quality of the FP cavity’s reflection spectrum. The unreleased device demonstrated an extinction ratio around 1.90, the released device achieved 61, and the hemispherical device achieved 253, providing a strong signal to observe changes in the free spectral range of the device’s reflection response. The reflectance of the photopolymer was also estimated to be between 0.2 and 0.3 over the spectrum of interest. The dual-cavity devices include both an open cavity, which can interact with an interstitial medium, and a second solid cavity, which provides a static reference reflection. The hemispherical dual-cavity device further improves the quality of the reflection signal with a more consistent resonance, and reduced sensitivity to misalignment. These advanced features, which are very challenging to realize with traditional planar microfabrication techniques, are fabricated in a single patterning step. The usability of these FP cavities as thermal radiation sensors with excellent linear response and sensitivity over a broad range of temperature is reported. The 3D structuring capability the 2PP process has enabled the creation of a suspended FP heat sensor that exhibited linear response over the temperature range of 20 oC –120 oC; temperature sensitivity of ~50 pm oC−1 at around 1550 nm wavelength; and sensitivity improvement of better than 9x of the solidly-mounted sensors.
Rapid Identiﬁcation and Enumeration of Saccharomyces cerevisiae Cells in Wine by Real-Time PCR

Despite the beneﬁcial role of Saccharomyces cerevisiae in the food industry for food and beverage production, it is able to cause spoilage in wines. We have developed a real-time PCR method to directly detect and quantify this yeast species in wine samples to provide winemakers with a rapid and sensitive method to detect and prevent wine spoilage. Speciﬁc primers were designed for S. cerevisiae using the sequence information obtained from a cloned random ampliﬁed polymorphic DNA band that differentiated S. cerevisiae from its sibling species Saccharomyces bayanus , Saccharomyces pastorianus , and Saccharomyces paradoxus . The speciﬁcity of the primers was demonstrated for typical wine spoilage yeast species. The method was useful for estimating the level of S. cerevisiae directly in sweet wines and red wines without preenrichment when yeast is present in concentrations as low as 3.8 and 5 CFU per ml. This detection limit is in the same order as that obtained from glucose-peptone-yeast growth medium (GPY). Moreover, it was possible to quantify S. cerevisiae in artiﬁcially contaminated samples accurately. Limits for accurate quantiﬁcation in wine were established, from 3.8 (cid:1) 10 5
A 0.35µm CMOS Pierce Oscillator for MEMS SAW Resonator

— This paper presents the pre and post layout simulation results for a pierce oscillator integrated with MEMS SAW resonator. The oscillator is designed to be interface with 1.78GHz MEMS SAW resonator. The pierce oscillator has achieved 18dB gain, 1.8GHz bandwidth and about 100 o phase performance. The simulation is done using CMOS 0.35u technology. The pre layout simulation of MEMS oscillator is sustained at 1.775GHz, with 0.8V voltage swing. The post layout simulation is sustained at 1.766GHz and 0.35V voltage swing. The phase noise performance after post layout simulation is 97.94dBc/Hz at 100kHz cutoff frequency.
Centrifugally Spun α -Fe 2 O 3 / TiO 2 / Carbon Composite Fibers as Anode Materials for Lithium-Ion Batteries

: We report results on the electrochemical performance of ﬂexible and binder-free α -Fe 2 O 3 / TiO 2 / carbon composite ﬁber anodes for lithium-ion batteries (LIBs). The composite ﬁbers were produced via centrifugal spinning and subsequent thermal processing. The ﬁbers were prepared from a precursor solution containing PVP / iron (III) acetylacetonate / titanium (IV) butoxide / ethanol / acetic acid followed by oxidation at 200 ◦ C in air and then carbonization at 550 ◦ C under ﬂowing argon. The morphology and structure of the composite ﬁbers were characterized using X-ray di ﬀ raction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS), and thermogravimetric analysis (TGA). These ternary composite ﬁber anodes showed an improved electrochemical performance compared to the pristine TiO 2 / C and α -Fe 2 O 3 / C composite ﬁber electrodes. The α -Fe 2 O 3 / TiO 2 / C composite ﬁbers also showed a superior cycling performance with a speciﬁc capacity of 340 mAh g − 1 after 100 cycles at a current density of 100 mA g − 1 , compared to 61 mAh g − 1 and 121 mAh g − 1 for TiO 2 / C and α -Fe 2 O 3 / C composite electrodes, respectively. The improved electrochemical performance and the simple processing of these metal oxide / carbon composite ﬁbers make them promising candidates for the next generation and cost-e ﬀ ective ﬂexible binder-free anodes for LIBs. electrochemical performance when compared to TiO 2 / C and α -Fe 2 O 3 / C ﬁbers. The high capacity of α -Fe 2 O 3 and the stability of the TiO 2 led to the high performance and excellent cycling stability of the ternary electrode. To the best of our knowledge, these are the ﬁrst results reported on binder-free α -Fe 2 O 3 / TiO 2 / C composite ﬁbers for use as anodes in LIBs. The mass production of ﬁbers by centrifugal spinning, along with the excellent electrochemical performance and ﬂexibility of these anodes, make these ﬁbers good candidates for next generation electrode materials for high power LIBs.
Methodolgy for Embedding Cancer Germline Variants

Genetic variations between individuals come from two different mechanisms. Germline Variants are inherited from our parents. In contrast, Somatic Mutations are acquired during the lifetime of an individual due to errors in the DNA replication mechanism, exposure to external factors, and imperfect repair processes. An average human genome presents a few million sequence variants compared to the reference genome [5]. Germline variants are part of an individual’s genetic makeup and are shared between all cells, while somatic mutations are present only in a portion of them. Both these mechanisms play a crucial role in complex disorders, especially in cancer [8]. However, common genetic variants explain only a small portion of the genetic burden in carcinogenesis [3]. While some known inherited mutations carry considerable risks, such as mutations in the TP53 gene that lead to a 90% lifetime risk of developing cancer for mutation carriers [13], the role of inherited variants in the development of cancer is not yet wholly understood [15]. One of the most commonly accepted models of the impact of germline variants on cancer is Knudson’s two-hit hypothesis [14]. In this model, one allele of a tumour-suppressor gene is affected by a germline variant. A somatic mutation can cause Loss of Heterozygosity (LOH) and disrupt the second allele, thus initiating the oncogenesis process. An incredibly challenging hurdle in our understanding of cancer is that the vast majority of mutations occur in non-coding portions of the genome, and a non-trivial number of such mutations are driver mutations [16, 12, 7]. Mutations
Exploring Interconnections Between Machine Learning and Operations Strategy

Within the data science and artificial intelligence fields of study, machine learning have supported performance improvement in medicine, manufacturing, law and even sport environments. The purpose of this paper is to investigate how machine learning has been used as a tool to improve the assertive-ness of decision-making, providing competitive advantages in the wide field of operations management. This exploratory research analyzes the content of five machine-learning studies, relating each of them to Slack’s strategy pillars: cost, speed, quality, flexibility and dependability. Research design was limited to Scopus’ papers published exclusively in high impact journals. Results emphasize the important role of machine learning in organizational competitive advantages and limitations are used to address further research suggestions, extending the present investigation with a more extensive bibliographic portfolio analysis. The contribution of this paper is a matrix analysis of how machine-learning projects indirectly contribute to at least three strategy dimensions simultaneously. Complementarily, an illustration was built for a better comprehension of the interrelationships among the strategic pillars reinforced by the analyzed studies.
Stem Cell Repor ts Electrical Guidance of Human Stem Cells in the Rat Brain

Limited migration of neural stem cells in adult brain is a roadblock for the use of stem cell therapies to treat brain diseases and injuries. Here, we report a strategy that mobilizesand guides migrationof stem cells in the brain in vivo . We developed a safe stimulation paradigm to deliver directional currents in the brain. Tracking cells expressing GFP demonstrated electrical mobilization and guidance of migration of human neural stem cells, even against co-existing intrinsic cues in the rostral migration stream. Transplanted cells were observed at 3 weeks and 4 months after stimulation in areas guided by the stimulation currents, and with indications of differentiation. Electrical stimulation thus may provide a potential approach to facilitate brain stem cell therapies.
Jovana Čukuranović MORPHOMETRIC CHARACTERISTICS OF JUGULAR FORAMEN AND SIGMOID SINUS GROOVE: THEIR POSSIBLE CONNECTIONS WITH HIGH JUGULAR

The anterior cerebral artery is a medial terminal branch of the cerebral part of the internal carotid artery on both sides. These paired arteries are connected by the anterior communicating artery. Different abnormalities of the anterior communicating–anterior cerebral arteries can include an aplasia or hypoplasia, or variable origin and/or course and/or termination, or fenestration, or duplication or multiplication or persistence of primitive or additional vessels. The aim of this manuscript was to investigate the relationships of morphological abnormalities of an anterior communicating–anterior cerebral complex in human adults of Serbian population. Material represented 266 human cadavers autopsied at the Institute for Forensic Medicine in Niš. Cerebral arteries were investigated macroscopically, under the glass; outer vessel’s diameter was measured using ImageJ processing program. A total of 87 cases or 32.71% of different abnormalities of the anterior communicating–anterior cerebral complex were found and classified into six groups. The group of duplications of the anterior communicating artery with an incidence of 18.04% was the most frequent. The finding of only four aneurysms on the anterior communicating artery indicates that there was no significant difference in the rate of aneurysms in individuals of Serbian population with and without fenestrations or duplications or multiplications of the anterior cerebral–anterior communicating complex.
A Memory Controller for the DIMM Tree Architecture

—The dual in-line memory module (DIMM) tree architecture was proposed to solve signal integrity and data access latency problems of many-DIMM system. Although the DIMM tree demands a memory controller specific to it, there has been little research on the memory controller for the DIMM tree. For this reason, this paper proposes a new memory controller architecture for the DIMM tree. This architecture was modeled using DRAMSim2 for its verification and analysis, and the experimental results show that the proposed DIMM tree memory controller works properly and efficiently.
Interaction of Hazardous Heavy Metals with Humans and Environment and their Toxicological Impacts

— Heavy metals are non-biodegradable segments of the world's surface that gather and endure uncertainly in the climate because of human exercises. Since the mechanical rebellion, the incorporated convergence of Cd, As, Hg, Pb, Cu, and Zn has steadily harmed soil and water assets, bringing about monstrous yield misfortunes in plants. These worries have become a significant wellspring of coherent concern. To expand plant productivity, it's basic to comprehend the subatomic and physiological reaction of plants to critical metal pressing factor. Late examination has expanded our comprehension of how plant synthetic substances put together and facilitate improvement reaction to numerous normal prompts to support life. In this examination, we will investigate the modern information on the immediate and backhanded impacts of perilous Heavy metals on people, just as their capacity and pessimistic results in soil contamination and the climate.
The Regenerative Vibrations Influence on the Mechanical Actions in Turning

In manufacturing during the cutting process the appearance of vibrations can not be avoided. These vibrations constitute a major obstacle to obtain a greater productivity and a better quality of the workpiece. It is thus necessary to develop models which make it possible to study, the totality of the 3D dynamic phenomena. Thanks to an experimental approach the complete torque of the mechanical actions is measured in the presence of the vibrations during a turning operation. This study makes it possible to analyze the variations of the central axis which is a significant parameter of the vibratory phenomena.