Miracle-dz/UniFAR-FTUs huggingface dataset:
Cell kinetic study of the endometrium by nonisotopic in situ hybridization for histone H3 messenger RNA and immunohistochemistry for Ki‐67 and for estrogen and progesterone receptors

We investigated the cell kinetics of the endometrium in hysterectomy specimens taken for leiomyoma from 22 women with regular ovulatory menstrual cycles. Formalin‐fixed, paraffin‐embedded tissue sections were examined for proliferating activity using histone H3 messenger RNA in situ hybridization (H3 mRNA‐ISH) and immunostaining for the Ki‐67 antigen. The relationship of the proliferative activity of endometrial cells to the immunohistochemical expression of the estrogen receptor (ER) and the progesterone receptor (PR) was also examined. During the menstrual cycle, H3 mRNA expression was observed in both the epithelial cells and the stromal cells of the endometrium. In the functional layer, the labeling indices for H3 mRNA (H3 mRNA‐LIs) in the epithelial cells peaked in the late proliferative phase, decreased sharply in the early secretory phase, and remained unchanged thereafter. On the other hand, H3 mRNA‐LIs of stromal cells displayed two peaks: one in the midproliferative phase and the other in the late secretory phase, the former peak being the greater. In the basal layer, epithelial cells and stromal cells showed low H3 mRNA‐LIs and no significant variation throughout the menstrual cycle. The H3 mRNA‐LIs correlated well with the Ki‐67‐LIs and were lower than the corresponding Ki‐67‐LIs. The regression coefficient (H3 mRNA‐LIs against the Ki‐67‐LIs) was 0.33 for epithelial cells and 0.49 for stromal cells, suggesting that the cell cycle time was longer for epithelial cells than for stromal cells. The proliferative activity of endometrial cells showed close relationships with the expressions of ER and PR in the endometrium. When used in combination with other proliferative markers in paraffin‐embedded tissue sections, H3 mRNA‐ISH could open broader perspectives on the cell kinetics of the endometrium. Anat Rec 266:234–240, 2002. © 2002 Wiley‐Liss, Inc.
Antioxidant And Anti-Inflammatory Properties Of A Flavonoid Fraction From The Leaves Of Voacanga Africana

In this study we used several models for evaluation of probable anti-inflammatory and anti-nociceptive effects of the flavonoid fraction of the leaves of Voacanga Africana , using mice and rats. The extract (50 - 150mg/kg, p.o) inhibited, in a dose-related manner, carrageenan induced paw oedema in rats. The extract caused a significant inhibition of the cotton-pellet granuloma. Vascular permeability induced by acetic-acid in the peritoneum of the animals was equally inhibited. The extract also exhibited significant analgesic action in acetic acid- induced pain in mice. There was reduction of writhings induced by acetic acid. In the formalin test, the extract caused inhibition of the neurogenic (first phase) and inflammatory phase (second phase) of formalin-induced pain. The extract also produced anti-nociception in the animals, as assessed by the tail flick, hot-plate and limb-withdrawal tests. These findings suggest that the leaf extract of Voacanga Africana has potent anti-imfiammatory and anti-nociceptive action. Key words: Voacanga africana; anti-inflammatory and anti-nociceptive activities. Nigerian Journal of Physiological Sciences Vol.19(1&2) 2004: 69-76
Machine learning‐based auto‐tuning for enhanced performance portability of OpenCL applications

Heterogeneous computing, combining devices with different architectures such as CPUs and GPUs, is rising in popularity and promises increased performance combined with reduced energy consumption. OpenCL has been proposed as a standard for programming such systems and offers functional portability. However, it suffers from poor performance portability, because applications must be retuned for every new device. In this paper, we use machine learning‐based auto‐tuning to address this problem. Benchmarks are run on a random subset of the tuning parameter spaces, and the results are used to build a machine learning‐based performance model. The model can then be used to find interesting subspaces for further search. We evaluate our method using five image processing benchmarks, with tuning parameter space sizes up to 2.3 M, using different input sizes, on several devices, including an Intel i7 4771 (Haswell) CPU, an Nvidia Tesla K40 GPU, and an AMD Radeon HD 7970 GPU. We compare different machine learning algorithms for the performance model. Our model achieves a mean relative error as low as 3.8% and is able to find solutions on average only 0.29% slower than the best configuration in some cases, evaluating less than 1.1% of the search space. The source code of our framework is available at https://github.com/acelster/ML‐autotuning.
Digitale Kuratierungstechnologien: Verfahren für die effiziente Verarbeitung, Erstellung und Verteilung qualitativ hochwertiger Medieninhalte

Das Kuratieren digitaler Informationen, Daten, Meldungen und Medieninhalte hat sich in den vergangenen Jahren als eine grundlegende Tätigkeit mit neuen Anforderungen herauskristallisiert, die von handelsüblichen ContentManagement-Systemen schon längst nicht mehr abgedeckt werden. Kuratieren ist ein komplexer wissensund zeitintensiver Prozess, in dem Redakteure oder interdisziplinäre Teams aus heterogenen Quellen ein neues, abgestimmtes Gesamtwerk entwickeln, das auf einen spezifischen Fokus ausgerichtet ist. Die hierzu erforderlichen Arbeiten umfassen das Auswählen, Zusammenfassen, zeitliche Einordnen, Internationalisieren, Anreichern, Visualisieren und Erklären der verschiedenen Inhalte, wobei insbesondere zu berücksichtigen ist, dass Geschwindigkeit, Volumen und Anzahl der Quellen (Online-Zeitungen, Nachrichtenportale, Twitter, Facebook, Instagram etc.) sowie der zu verarbeitenden Information stetig anwachsen. Ein Beispiel ist die Entwicklung eines interaktiven Exponats für ein Besucherzentrum, das bei Ausgrabungen gefundene Objekte mit Fotos, Beschreibungen und Zeitangaben auf einer Karte visualisiert und die Auswahl geeigneter Objekte, Erstellung entsprechender Inhalte, Gestaltung der Karte und Festlegung thematischer Perspektiven erfordert.
Nanogap Embedded Transistor for Investigation of Charge Properties in DNA

A new structure to investigate the charge trapping characteristics of a DNA is proposed. The structure of the proposed device is a field effect transistor (FET) with a nanogap in the dielectric layer. With the proposed device, the charge trapping characteristics of the DNA are confirmed without any adhesion problems and electrical contact instability. The extraction of both electron and hole trapping characteristics were analyzed with an n-channel and a p-channel FET, respectively. The results showed that guanine has plenty of hole trap sites with a shallow energy level, which explains why hole hopping dominantly occurs in the guanine base.
The carbon and chlorophyll content of phytoplankton from various nutrient regimes

We have measured the relationship between chlorophyll and carbon in phytoplankton cultures and natural populations of phytoplankton using simple standard extraction procedures without correction for degradation products. During exponential growth oi four cultures oi unicellular and colonial green algae and one diatom, chlorophy! l varied from 1.22 to 6.08% of the phytoplankton carbon content (i ~ 3.03%). The chlorophyll content of the cultures was lower during nitrogen and phosphorus deficiency. Results from natural populations of phytoplankton from eutrophic lakes and from a coastal marine station gave values mostly ranging from 1.5 to 3.7% chlorophyll, corresponding to carbon/chlorophyl! ratios of 27-67. If only a rough estimate of the phytoplankton carbon biomass is required, a simple, efficient extraction procedure can be used without any corrections for degradation products.
The Phosphoenolpyruvate Phosphotransferase System in Group A Streptococcus Acts To Reduce Streptolysin S Activity and Lesion Severity during Soft Tissue Infection

ABSTRACT Obtaining essential nutrients, such as carbohydrates, is an important process for bacterial pathogens to successfully colonize host tissues. The phosphoenolpyruvate phosphotransferase system (PTS) is the primary mechanism by which bacteria transport sugars and sense the carbon state of the cell. The group A streptococcus (GAS) is a fastidious microorganism that has adapted to a variety of niches in the human body to elicit a wide array of diseases. A ΔptsI mutant (enzyme I [EI] deficient) generated in three different strains of M1T1 GAS was unable to grow on multiple carbon sources (PTS and non-PTS). Complementation with ptsI expressed under its native promoter in single copy was able to rescue the growth defect of the mutant. In a mouse model of GAS soft tissue infection, all ΔptsI mutants exhibited a significantly larger and more severe ulcerative lesion than mice infected with the wild type. Increased transcript levels of sagA and streptolysin S (SLS) activity during exponential-phase growth was observed. We hypothesized that early onset of SLS activity would correlate with the severity of the lesions induced by the ΔptsI mutant. In fact, infection of mice with a ΔptsI sagB double mutant resulted in a lesion comparable to that of either the wild type or a sagB mutant alone. Therefore, a functional PTS is not required for subcutaneous skin infection in mice; however, it does play a role in coordinating virulence factor expression and disease progression.
Derivatives of the Evans function and (modified) Fredholm determinants for first order systems

The Evans function is a Wronskian type determinant used to detect point spectrum of differential operators obtained by linearizing PDEs about special solutions such as traveling waves, etc. This work is a sequel to the paper “Derivatives of (modified) Fredholm determinants and stability of standing and traveling waves”, published by F. Gesztesy, K. Zumbrun and the second author in J. Math. Pures Appl. 90, 160–200 (2008), where the Evans and Jost functions for the Schrödinger equations have been considered. In the current work, we study the Evans function for the general case of linear ODE systems, and choose it to agree with the modified Fredholm determinant of the respective Birman‐Schwinger type integral operator. The Evans function is thus the determinant of the matrix composed of the so‐called generalized Jost solutions. These are the solutions of the homogeneous perturbed differential equation which are asymptotic to some reference solutions of the unperturbed equation. One of the main results of the current paper is a formula for the derivative of the Evans function for the first order systems. Its proof uses a matrix composed of the newly introduced modified Jost solutions. These are the solutions of an inhomogeneous perturbed differential equation with the inhomogeneous term constructed by means of the above‐mentioned generalized Jost solutions.
GLUCURONIDATION OF THE ASPIRIN METABOLITE SALICYLIC ACID BY EXPRESSED UDP-GLUCURONOSYLTRANSFERASES AND HUMAN LIVER MICROSOMES

Acetylsalicylic acid (aspirin) is a common nonsteroidal anti-inflammatory drug used for treatment of pain and arthritis. In the body, acetylsalicylic acid is rapidly deacetylated to form salicylic acid. Both compounds have been proposed as anti-inflammatory agents. Major metabolites of salicylic acid are its acyl and phenolic glucuronide conjugates. Formation of these conjugates, catalyzed by UDP-glucuronosyltransferases (UGTs), decreases the amount of pharmacologically active salicylic acid present. We aimed to identify the UGTs catalyzing the glucuronidation of salicylic acid using both heterologously expressed enzymes and pooled human liver microsomes (HLMs) and to develop a liquid chromatographytandem mass spectrometry method to quantify glucuronidation activity of UGTs 1A1, 1A3, 1A4, 1A6, 1A7, 1A8, 1A9, 1A10, 2B4, 2B7, 2B15, and 2B17 Supersomes. All UGTs tested, except 1A4, 2B15, and 2B17, catalyzed salicylic acid phenolic and acyl glucuronidation. Ratios of salicylic acid phenolic to acyl glucuronide formation varied more than 12-fold from 0.5 for UGT1A6 to 6.1 for UGT1A1. These results suggest that all UGTs except 1A4, 2B15, and 2B17 might be involved in the glucuronidation of salicylic acid in vivo. From comparisons of apparent Km values determined in pooled HLMs and in expressed UGTs, UGT2B7 was suggested as a likely catalyst of salicylic acid acyl glucuronidation, whereas multiple UGTs were suggested as catalysts of phenolic glucuronidation. The results of this UGT screening may help target future evaluation of the effects of UGT polymorphisms on response to aspirin in clinical and population-based studies.
Disseminated Intravascular Coagulation: The Application and Utility of Diagnostic Tests

Normal hemostasis involves maintaining intravascular constituents in a liquid phase or suspension while concomitantly permitting local deposition of solid phase blood components in areas of vessel damage. In health it has been assumed, but never experimentally demonstrated, that a balance exists between a low-grade intravascular deposition of fibrin and its removal by fibrinolysis or cellular phagocytosis. Early clinical observations revealed that some severely ill patients developed signs of hemorrhage and massive bruising and had prolonged clotting times and thrombocytopenia. At postmortem, in some cases, fibrin thrombi were demonstrated in the micro vasculature. The diffuse nature of these thrombi gave rise to the term "disseminated intravascular coagulation" (DIC). Subsequently, coagulation factors were shown to be reduced. These findings give rise to the concept of "consumptive coagulopathy," a term sometimes used as a synonym for DIC. The currently accepted sequence of events in DIC involves activation of the coagulation system resulting in platelet consumption, thrombin generation, fibrin deposition, and secondary fibrinolysis. The net biologic effect of this process reflects a balance between fibrin deposition and fibrin clearance. The resulting clinical manifestations may be hemorrhage, when depletion of coagulation factors predominates, or ischemic tissue damage due to the effects of vascular occlusion. In this review the tests used in the diagnosis of DIC are critically evaluated. PHYSIOLOGY OF THE COAGULATION SYSTEM
Computer based simulation of laboratory experiments

The author is currently developing computer based simulations of practical laboratory experiments in engineering. He takes the view that the aim of computer based simulations is to provide a learning experience as close to that of the lab as possible. This requires that the learning outcomes and methodology of practical work be established. The paper starts with a review of published opinions on the intended learning outcomes of practical work. The views of staff and students of the School were established by conducting an internal survey. The paper then outlines the types of simulations possible on the computer before concentrating on the development of the operational simulations being used in the present context. The approach to obtaining fidelity in operation forms the main part of the paper. The author is currently engaged in evaluating the effectiveness of one of the packages. He discusses the approach being taken and his views on the advantages and disadvantages of simulation. It is hoped that a subsequent paper will publish the results of the evaluation.
Teager energy operated perceptual wavelet packet transform coefficients for arithmetic task classification from EEG signals

Recently the development of brain-computer interface applications has drawn the attention of research community as it can assist physically challenged people to communicate with their brain electroencephalogram (EEG) signal. In this paper, a Brain-Computer Interface (BCI) is designed using electroencephalogram (EEG) signals where the subjects have to think of only a single mental task. The presented BCI approach includes three stages: (a) filtering out the electrical frequency components and segmentation of the raw signals (b) Perceptual wavelet packet transform of the segments and calculating the Teager Energy(TE) of the subbands (c) classification using SVM classifier. Perceptual wavelet packet transform is used to decompose the EEG signals into a number of frequency bands, and Teager Energy is calculated to maintain distinguishable energy profiles of those bands which provide a maximum classification accuracy of about 100%.
The Geography of Retail Inventory

How different are retailers' inventory levels around the world? Specifically, are retailers' inventories constant across countries, converging, or at least co-integrating? These might be viewed as various forms of global determinism. To see which of these forms hold, I use a novel dataset integrated from Dow Jones, Edgar, Bureau van Dijk (Europe), World'Vest Base, Multex, KIS (Korea Information Service), Teikoku of Japan, Huaxia of China, and COMPUSTAT. The dataset consists of 27,000 firm-year observations for 4,100 retailers in 23 countries, for the period 1983 through 2004. I find evidence to reject all the three forms of global determinism. Instead, I report evidence consistent with an alternative hypothesis - local contingency - in which country effects can explain inventory differences around the world. I also show that this conclusion is robust in numerous ways.
Enhanced pressure response in ZnO nanorods due to spontaneous polarization charge

We present measurements of the induced charge flow when a compressive force is applied by contacting to a ZnO nanowire (NW). The measured charge transfer from the NW is over 104 times larger than expected from the strain-induced piezoelectric response, and is comparable in magnitude to the spontaneous polarization charge, associated with an ideal ZnO NW. A model is presented that compares the total energy of an isolated NW and external capacitor with the total energy when the capacitor and NW form a closed circuit. The analysis shows that it is possible, for realistic values of surface defect creation energy, to have spontaneous polarization charge transferred from a NW to an external capacitor when a circuit is completed between them. We propose that it is possible to use spontaneous polarization charge to get a significantly enhanced response in ZnO-based NW pressure sensors.
Carcinoma in situ of the colorectum: SEER trends by race, gender, and total colorectal cancer

To determine if Americans of African origin (blacks) have less access to colonoscopic polypectomy than Americans of European origin (whites), the rate of carcinoma in situ of the colorectum (CIS), a disease more similar to benign adenoma of the colorectum than invasive cancer in its symptomatology, discovery, and treatment, was determined in the United States from 1973 to 1994. The hypothesis being tested is that CIS will be far less common in blacks than in whites and that rates of CIS should be increasing in whites from 1973 to 1994.
Integrating Cognitive and Emotional Parameters into Designing Adaptive Hypermedia Environments

This paper introduces a “new” user profiling model in the field of adaptive hypermedia, which integrates cognitive and emotional parameters, in particular (but not exclusively) when information perception and processing are involved in a Webbased learning environment. The proposed model combines theories from the field of cognitive psychology, applying them on Web-based interactions, in order to improve learning performance and, most importantly, to personalize Webcontent to users’ needs and preferences, eradicating known difficulties that occur in a “one size fits all” approach. The specific article emphasizes on the emotional aspect of our model, since it presents results of our efforts to measure and include Emotional Control parameters, by re-constructing a theory that addresses emotion and is feasible in Weblearning
Confidentiality Protection in Cloud Computing Systems

Current cloud computing systems pose serious limitation to protecting users’ data confidentiality. Since users’ sensitive data is presented in unencrypted forms to remote machines owned and operated by third party service providers, the risks of unauthorized disclosure of the users’ sensitive data by service providers may be high. Many techniques for protecting users’ data from outside attackers are available, but currently there exists no effective way for protecting users’ sensitive data from service providers in cloud computing. In this paper, an approach is presented to protecting the confidentiality of users’ data from service providers, and ensures that service providers cannot access or disclose users’ confidential data being processed and stored in cloud computing systems. Our approach has three major aspects: 1) separating software service providers and infrastructure service providers in cloud computing, 2) hiding information of the owners of data, and 3) data obfuscation. An example to show how our approach can protect the confidentiality of users’ data from service providers in cloud computing is given. Experimental results are presented to show that our approach has reasonable performance.
Assessing sperm chromatin and DNA damage: clinical importance and development of standards

Over the past 20 years, numerous new methods have been developed to identify changes in the organization and composition of sperm chromatin as well as to determine the extent of DNA damage in the nuclei of spermatozoa. Although these methods are being used effectively in assessing how toxicants act on sperm chromatin quality in agricultural settings, their use as complementary biomarkers of sperm quality in assessing male fertility remains controversial. We review some key aspects of the assessment of sperm chromatin quality and DNA damage and identify some of the most widely used tests to monitor these endpoints. An approach to validate three tests by standardizing methodology and determining interlaboratory variation for each test using a standard set of samples is outlined.
OC-192 receiver in standard 0.18/spl mu/m CMOS

A fully integrated OC-192 multi-rate (9.95Gb/s-10.71Gb/s) receiver uses standard 0.18/spl mu/m CMOS. The circuit consists of an input amplifier, CDR, 1:16 demux and 18 LVDS drivers. The chip exceeds SONET jitter tolerance spec by >100%. Recovered 10Gb/s clock jitter is <4mUl(rms). The input sensitivity is <50mV with 870mW at 1.8V.
Toward Building a Legal Knowledge-Base of Chinese Judicial Documents for Large-Scale Analytics

Columbia Law School 435 W. 116th St., New York, NY 10025 (212) 854-0678; bl2075@columbia.edu EXPERIENCE COLUMBIA LAW SCHOOL, New York Robert L. Lieff Professor of Law 2011Professor of law 2007-2011 Associate professor of law 2002-2007 Director, Hong Yen Chang Center for Chinese Legal Studies 2021Director, Center for Chinese Legal Studies 2002-2020 Director, Parker School of Foreign and Comparative Law 2018SULLIVAN & CROMWELL, London 2000-2002 Associate in general practice group. Practice focused on international securities transactions. SUPREME COURT OF THE UNITED STATES, Washington, D.C. 1999-2000 Law clerk to Justice David H. Souter. UNITED STATES COURT OF APPEALS, FIRST CIRCUIT, Boston 1998-1999 Law clerk to Judge Sandra L. Lynch. PAUL, WEISS, RIFKIND, WHARTON & GARRISON, New York and Beijing Summer 1997 Conducted research on corporate and environmental law. Assisted in joint venture negotiations. INSTITUTE OF LAW, CHINESE ACADEMY OF SOCIAL SCIENCES, Beijing Summer 1996 Researched Chinese environmental law, public interest law, and class action litigation. COUDERT BROTHERS, Beijing 1994-1995 Assisted in construction contract arbitration. Prepared and translated joint venture contracts.