Miracle-dz/UniFAR-FTUs huggingface dataset:
Au-Decorated ZnFe2O4 Yolk-Shell Spheres for Trace Sensing of Chlorobenzene.

Noble metal supported on metal oxides are promising materials for widely applying on gas sensors, because of their enviable physical and chemical properties in enhancing the sensitivity and selectivity. Herein, pristine ZFO yolk-shell spheres composed of ultrathin nanosheets and ultrasmall nanoparticles decorated with nano-sized Au particles with diameter of 1-2 nm are fabricated using the method of solution-phase deposition-precipitation. As a result, the Au@ZFO yolk-shell spheres based sensor exhibits significantly sensing performances for chlorobenzene. In comparison with pristine ZFO, the response (Rair/Rgas = 90.9) of Au@ZFO based sensor with a low detection limit of 100 ppb increases four-fold exposed to 10 ppm chlorobezene at 150 oC. Excitingly, the sensing response for chlorobenzene is the highest among metal oxides based sensors. Moreover, the sensors can be further applied on the field of chlorobenzene monitoring owing to its outstanding selectivity. The results elaborated that the enhanced sensing mechanism is mainly attributed to the effects of electronic sensitization and chemical sensitization, which are induced by the Au nanoparticles on the surface of ZFO yolk-shell spheres. DFT calculations further illustrated that the existence of Au nanoparticles exhibits higher adsorption energy and net charge transfer for CB. In addition, the relationship between the sensing performances of pristine ZFO and Au@ZFO yolk-shell spheres for chlorobenzene and the factors of Au loading amount, operating temperature and humidity was also fully investigated in this work.
Postoperative bleeding in patients taking oral anticoagulation therapy after 'All-on-four' rehabilitation: A case-control study.

PURPOSE The aim of this study was to estimate bleeding prevalence and postoperative peri-oral purpura after full-arch immediate implant rehabilitation according to the 'All-on-four' technique, in patients on different oral anticoagulant therapies (warfarin and rivaroxaban). MATERIALS AND METHODS A total of 120 patients (47 women, 73 men, mean age 66.4 years) presented with edentulous or partially edentulous arches. All patients were treated with immediate full-arch fixed prostheses (28 maxillary, 34 mandibular), each supported by four implants (two vertical, two distally tilted). Participants were divided in three groups: 40 patients under treatment with warfarin formed group A, 40 patients under treatment with rivaroxaban composed group B, and 40 healthy subjects composed the control group. As the primary outcome measure, mild, moderate and severe postoperative bleeding was recorded. As the secondary outcome measure, the presence of postoperative petechiae, ecchymoses and haematomas in oral and peri-oral tissues was recorded. RESULTS Patients under treatment with warfarin (group A) showed a higher prevalence of postoperative bleeding (P = 0.002) and purpura (P = 0.012) in comparison with other groups. No severe bleeding took place and no haematomas appeared in any patient. Prefabricated metal-reinforced, screw-retained, acrylic resin provisional restorations were delivered in all patients. CONCLUSIONS The preliminary results of this prospective case-control study showed how immediate rehabilitation according the 'All-on-four' technique could be a safe and predictable procedure in anticoagulated patients where anticoagulation therapy is not discontinued or modified.
Is numeracy a barrier to glycaemic control in Type 1 diabetes mellitus? A synthesis of current literature

Aims: Healthcare professionals rely on patients’ health literacy and numeracy when providing education to enable self-management of diabetes. We review existing evidence for the impact of health literacy and numeracy on self-care processes in adults with Type 1 diabetes mellitus (T1DM). Methods: A systematic review and narrative synthesis was performed. Four electronic databases were searched from inception to October 2015. Inclusion criteria included at least 70% adults (>17 years old) T1DM population, measurement of health literacy or numeracy with validated score and measure of self-care. Results: A total of 972 articles were identified. Three articles met the inclusion criteria. There was heterogeneity of the studies although all studies used glycaemic control as the primary outcome. Six themes were identified, in particular, the association between numeracy and glycaemic control (p = 0.004, p = 0.066) in T1DM. No association was seen with health literacy. Conclusions: Low numeracy appears to be associated with poorer glycaemic control in adults with T1DM, likely reflecting the skills needed for conventional insulin dose adjustment in T1DM. This review calls for more work to investigate this association further, aid identification and produce strategies to overcome low numeracy.
Extensive Therapeutic Drug Monitoring of Colistin in Critically Ill Patients Reveals Undetected Risks

(1) Background: With the rise of multi-/pan-drug resistant (MDR/PDR) pathogens, the less utilized antibiotic Colistin has made a comeback. Colistin fell out of favor due to its small therapeutic range and high potential for toxicity. Today, it is used again as a last resort substance in treating MDR/PDR pathogens. Although new guidelines with detailed recommendations for Colistin dosing are available, finding the right dose in critically ill patients with renal failure remains difficult. Here, we evaluate the efficiency of the current guidelines’ recommendations by using high resolution therapeutic drug monitoring of Colistin. (2) Methods: We analyzed plasma levels of Colistin and its prodrug colisthimethate sodium (CMS) in 779 samples, drawn from eight PDR-infected ICU patients, using a HPLC-MS/MS approach. The impact of renal function on proper Colistin target levels was assessed. (3) Results: CMS levels did not correlate with Colistin levels. Over-/Underdosing occurred regardless of renal function and mode of renal replacement therapy. Colistin elimination half-time appeared to be longer than previously reported. (4) Conclusion: Following dose recommendations from the most current guidelines does not necessarily lead to adequate Colistin plasma levels. Use of Colistin without therapeutic drug monitoring might be unsafe and guideline adherence does not warrant efficient target levels in critically ill patients.
Combining Transcranial Direct Current Stimulation and Transcutaneous Electrical Nerve Stimulation to Relieve Persistent Pain in a Patient Suffering from Complex Regional Pain Syndrome: A Case Report

Purpose Complex regional pain syndrome (CRPS) is a rare neuropathic pain condition characterized by sensory, motor and autonomic alterations. Previous investigations have shown that transcranial direct current stimulation (tDCS) and transcutaneous electrical nerve stimulation (TENS) can alleviate pain in various populations, and that a combination of these treatments could provide greater hypoalgesic effects. In the present case report, we describe the effect of tDCS and TENS treatment on pain intensity and unpleasantness in a patient suffering from chronic CRPS. Results The patient was a 37-year-old woman, suffering from left lower limb CRPS (type I) for more than 5 years. Despite medication (pregabalin, tapentadol, duloxetine), rehabilitation treatments (sensorimotor retraining, graded motor imagery) and spinal cord stimulation (SCS), the participant reported moderate to severe pain. Treatments of tDCS alone (performed with SCS turned off during tDCS application, 1 session/day, for 5 consecutive days) did not significantly decrease pain. Combining tDCS with TENS (SCS temporarily turned off during tDCS, 1 session/day, for 5 consecutive days) slightly reduced pain intensity and unpleasantness. Discussion Our results suggest that combining tDCS and TENS could be a therapeutic strategy worth investigating further to relieve pain in chronic CRPS patients. Future studies should examine the efficacy of combined tDCS and TENS treatments in CRPS patients, and other chronic pain conditions, with special attention to the cumulative and long-term effects and its effect on function and quality of life.
A Novel Change Detection Method Based on Statistical Distribution Characteristics Using Multi-Temporal PolSAR Data

Unsupervised change detection approaches, which are relatively straightforward and easy to implement and interpret, and which require no human intervention, are widely used in change detection. Polarimetric synthetic aperture radar (PolSAR), which has an all-weather response capability with increased polarimetric information, is a key tool for change detection. However, for PolSAR data, inadequate evaluation of the difference image (DI) map makes the threshold-based algorithms incompatible with the true distribution model, which causes the change detection results to be ineffective and inaccurate. In this paper, to solve these problems, we focus on the generation of the DI map and the selection of the optimal threshold. An omnibus test statistic is used to generate the DI map from multi-temporal PolSAR images, and an improved Kittler and Illingworth algorithm based on either Weibull or gamma distribution is used to obtain the optimal threshold for generating the change detection map. Multi-temporal PolSAR data obtained by the Radarsat-2 sensor over Wuhan in China are used to verify the efficiency of the proposed method. The experimental results using our approach obtained the best performance in East Lake and Yanxi Lake regions with false alarm rates of 1.59% and 1.80%, total errors of 2.73% and 4.33%, overall accuracy of 97.27% and 95.67%, and Kappa coefficients of 0.6486 and 0.6275, respectively. Our results demonstrated that the proposed method is more suitable than the other compared methods for multi-temporal PolSAR data, and it can obtain both effective and accurate results.
Ex Vivo Rat Transected Spinal Cord Slices as a Model to Assess Lentiviral Vector Delivery of Neurotrophin-3 and Short Hairpin RNA against NG2

The failure of the spinal cord to regenerate can be attributed both to a lack of trophic support for regenerating axons and to upregulation of inhibitory factors such as chondroitin sulphate proteoglycans including NG2 following injury. Lentiviral vector-mediated gene therapy is a possible strategy for treating spinal cord injury (SCI). This study investigated the effect of lentiviral vectors expressing Neurotrophin-3 (NT-3) and short-hairpin RNA against NG2 (NG2 sh) to enhance neurite outgrowth in in vitro and ex vivo transection injury models. Conditioned medium from cells transduced with NT-3 or shNG2 lentiviruses caused a significant increase in neurite length of primary dorsal root ganglia neurons compared to the control group in vitro. In an ex vivo organotypic slice culture (OSC) transduction with Lenti-NT-3 promoted axonal growth. Transducing OSCs with a combination of Lenti-NT-3/NG2 sh lead to a further increase in axonal growth but only in injured slices and only within the region adjacent to the site of injury. These findings suggest that the combination of lentiviral NT-3 and NG2 sh reduced NG2 levels and provided a more favourable microenvironment for neuronal regeneration after SCI. This study also shows that OSCs may be a useful platform for studying glial scarring and potential SCI treatments.
Patients with Cholangiocarcinoma Present Specific RNA Profiles in Serum and Urine Extracellular Vesicles Mirroring the Tumor Expression: Novel Liquid Biopsy Biomarkers for Disease Diagnosis

Cholangiocarcinoma (CCA) comprises a group of heterogeneous biliary cancers with dismal prognosis. The etiologies of most CCAs are unknown, but primary sclerosing cholangitis (PSC) is a risk factor. Non-invasive diagnosis of CCA is challenging and accurate biomarkers are lacking. We aimed to characterize the transcriptomic profile of serum and urine extracellular vesicles (EVs) from patients with CCA, PSC, ulcerative colitis (UC), and healthy individuals. Serum and urine EVs were isolated by serial ultracentrifugations and characterized by nanoparticle tracking analysis, transmission electron microscopy, and immunoblotting. EVs transcriptome was determined by Illumina gene expression array [messenger RNAs (mRNA) and non-coding RNAs (ncRNAs)]. Differential RNA profiles were found in serum and urine EVs from patients with CCA compared to control groups (disease and healthy), showing high diagnostic capacity. The comparison of the mRNA profiles of serum or urine EVs from patients with CCA with the transcriptome of tumor tissues from two cohorts of patients, CCA cells in vitro, and CCA cells-derived EVs, identified 105 and 39 commonly-altered transcripts, respectively. Gene ontology analysis indicated that most commonly-altered mRNAs participate in carcinogenic steps. Overall, patients with CCA present specific RNA profiles in EVs mirroring the tumor, and constituting novel promising liquid biopsy biomarkers.
Automated Indoor Image Localization to Support a Post-Event Building Assessment

Image data remains an important tool for post-event building assessment and documentation. After each natural hazard event, significant efforts are made by teams of engineers to visit the affected regions and collect useful image data. In general, a global positioning system (GPS) can provide useful spatial information for localizing image data. However, it is challenging to collect such information when images are captured in places where GPS signals are weak or interrupted, such as the indoor spaces of buildings. The inability to document the images’ locations hinders the analysis, organization, and documentation of these images as they lack sufficient spatial context. In this work, we develop a methodology to localize images and link them to locations on a structural drawing. A stream of images can readily be gathered along the path taken through a building using a compact camera. These images may be used to compute a relative location of each image in a 3D point cloud model, which is reconstructed using a visual odometry algorithm. The images may also be used to create local 3D textured models for building-components-of-interest using a structure-from-motion algorithm. A parallel set of images that are collected for building assessment is linked to the image stream using time information. By projecting the point cloud model to the structural drawing, the images can be overlaid onto the drawing, providing clear context information necessary to make use of those images. Additionally, components- or damage-of-interest captured in these images can be reconstructed in 3D, enabling detailed assessments having sufficient geospatial context. The technique is demonstrated by emulating post-event building assessment and data collection in a real building.
Fluid Rheological Effects on the Flow of Polymer Solutions in a Contraction–Expansion Microchannel

A fundamental understanding of the flow of polymer solutions through the pore spaces of porous media is relevant and significant to enhanced oil recovery and groundwater remediation. We present in this work an experimental study of the fluid rheological effects on non-Newtonian flows in a simple laboratory model of the real-world pores—a rectangular sudden contraction–expansion microchannel. We test four different polymer solutions with varying rheological properties, including xanthan gum (XG), polyvinylpyrrolidone (PVP), polyethylene oxide (PEO), and polyacrylamide (PAA). We compare their flows against that of pure water at the Reynolds (Re) and Weissenburg (Wi) numbers that each span several orders of magnitude. We use particle streakline imaging to visualize the flow at the contraction–expansion region for a comprehensive investigation of both the sole and the combined effects of fluid shear thinning, elasticity and inertia. The observed flow regimes and vortex development in each of the tested fluids are summarized in the dimensionless Wi−Re and χL−Re parameter spaces, respectively, where χL is the normalized vortex length. We find that fluid inertia draws symmetric vortices downstream at the expansion part of the microchannel. Fluid shear thinning causes symmetric vortices upstream at the contraction part. The effect of fluid elasticity is, however, complicated to analyze because of perhaps the strong impact of polymer chemistry such as rigidity and length. Interestingly, we find that the downstream vortices in the flow of Newtonian water, shear-thinning XG and elastic PVP solutions collapse into one curve in the χL−Re space.
Botulinum Toxin Therapy for Managing Sleep Bruxism: A Randomized and Placebo—Controlled Trial

The purpose of this study is to evaluate the effects of botulinum toxin type A (BoNT-A) for managing sleep bruxism (SB) in a randomized, placebo-controlled trial. Thirty SB subjects were randomly assigned into two groups evenly. The placebo group received saline injections into each masseter muscle, and the treatment group received BoNT-A injections into each masseter muscle. Audio–video–polysomnographic recordings in the sleep laboratory were made before, at four weeks after, and at 12 weeks after injection. Sleep and SB parameters were scored according to the diagnostic and coding manual of American Academy of Sleep Medicine. The change of sleep and SB parameters were investigated using repeated measures analysis of variance (RM-ANOVA). Twenty-three subjects completed the study (placebo group 10, treatment group 13). None of the SB episode variables showed a significant time and group interaction (p > 0.05) except for electromyography (EMG) variables. The peak amplitude of EMG bursts during SB showed a significant time and group interaction (p = 0.001). The injection decreased the peak amplitude of EMG bursts during SB only in the treatment group for 12 weeks (p < 0.0001). A single BoNT-A injection cannot reduce the genesis of SB. However, it can be an effective management option for SB by reducing the intensity of the masseter muscle.
The Associations between Family-Related Factors and Excessive Internet Use in Adolescents

This study examined the relationship between Excessive Internet Use (EIU) in adolescents and their family environment, namely the family type, the family economic status, the effect of parental care, the level of parental control, the amount of parental monitoring, the quality of communication, and the time spent together. The study was based on data from an international survey, Health Behaviour in School Aged Children (HBSC), conducted in Slovakia. The sample representative for adolescents included 2547 participants (51% boys) aged 13–15. Multiple-step linear regression revealed that higher parental care and parental monitoring predicted lower EIU, while higher parental overprotection and lower socioeconomic status predicted higher EIU. The results suggest that both so-called optimal parenting (i.e., the balance of emotional warmth and protection) and the adolescent′s autonomy lower the risk of EIU. Family factors explained about 14% of the variance, which suggests that aside from personal, cognitive and affective factors, a close social environment also plays an important role in adolescence EIU.
Post-coital Acute Rectovaginal fistula: a rare case report

Most case of Rectovaginal fistula are caused by obstetric injuries, surgical complications, infections and rarely may follow coital Acts. Postcoital non obstetric vaginal laceration due to consensual sexual Act are generally minute mucosal tears and generally heal by themselves, but in some cases, the vaginal mucosa is lacerated deeper and bleeding may require suturing of open vessels. The aim of this case report is to highlight a rare case of acute low rectovaginal fistula which a 25 yrs old women developed by penile penetration through the full thickness of rectovaginal wall after consensual intercourse and its management in emergency settings.
Outcome Measures in Functional Urology : Towards evaluation through patient reported outcome measures?

markdownabstractAbstract Pelvic floor disorders are characterized by four domains: urinary symptoms, anorectal symptoms, pelvic organ prolapse and sexual dysfunction. The symptoms of the different domains have a significant impact on patient’s quality of life. Traditional outcome measures, such as bladder diary, urodynamics, and ultrasound, have been used for the evaluation of pelvic floor disorders and treatment efficacy. These do not take the patient’s perspective into account which has resulted in a discrepancy between patients and physicians about the impact of symptoms and effectiveness of treatment. Patient reported outcome measures (PROMs) have been developed to resolve this discordance between patients and physicians. The aim of this thesis is to determine the position of PROMs as an outcome measure in functional urology. The first part of this thesis evaluates two additional treatment options using only traditional outcome measures and a combination of PROMs and traditional outcome measures. We have found that onabotulinum toxin-A is effective in the treatment of therapy-refractory children with dysfunctional voiding. Furthermore, the results with intermittent sacral neuromodulation suggest it to be a more cost-effective option than ‘standard’ continuous sacral neuromodulation. The second part of this thesis focusses on the quality of PROMs used in clinical practice. During the assessment of validation studies and measurement properties using the COSMIN checklist, variable evidence was found for the quality of the PROMs to evaluate sexual function in neurological patients. An essential point of improvement is to adequately assess all measurement properties, specifically responsiveness and minimal important change, before the PROMs can be used in clinical practice. In the third part of this thesis four Dutch versions of PROMs assessing severity of pelvic floor disorders and their impact on quality of life in children and adults are validated, thereby providing adequate Dutch versions of these PROMs. In conclusion, the findings presented in this thesis support that PROMs in functional urology sufficiently represent the patient’s perspective and PROMs could assist to manage patient expectation and improve patient satisfaction. However, it remains important to guarantee adequate quality of PROMs used in clinical practice. One of the future perspectives for the field of functional urology is to develop a prediction model based on different outcome measure to predict treatment success for individual patients.
Work Engagement of Nurses in Private Hospitals

This study examined the impact of organizational, personal, team, job demand factors and mediating effects of team and affective commitments on nurses’ work engagement. Health workers’ work engagement has positive effect on patient satisfaction; nurses constitute a major group among health workers. To find reliability of the instruments pilot study was conducted in three hospitals of Kolkata (India) in which 175 nurses participated. In the main study, 504 nurses from five hospitals in Kolkata participated. Correlation, regression analysis and Sobel test was used to find out the relationships. Perceived organizational support, leader–member exchange, team–member exchange, workplace friendship, all relate positively to work engagement. Nursing role stress negatively relates to work engagement. Team commitment positively mediates the relationship between leader–member exchange, team member exchange and workplace friendship with work engagement. Affective commitment positively mediates the relationship between perceived organizational support and core self-evaluation with work engagement and negatively mediates the relationship between nursing role stress and work engagement. Result of the study shall be helpful for health care managers to devise appropriate strategies for enhancement of work engagement of nurses.