Miracle-dz/UniFAR-FTUs huggingface dataset:
Improving Genetic Knowledge Among Physicians: A Necessity in the Era of Genomic Medicine

Background: Genetic analyses have experienced rapid development over the past decades. This evolution is accompanied by a considerable increase in indications in clinical practice. As a result, physicians are exposed to prescribing and understanding genetics results in their daily practice. The objective was to assess the knowledge of young physicians on new genetic techniques and their expectations concerning molecular biology education. Methods: This study is based on the results of an anonymized questionnaire on genetics knowledge sent to young French physicians specialized in medical oncology, radiation therapy, and clinical hematology in France; and on a retrospective analysis of nonconformities to requirements of the ISO 15189 accreditation standard in genetics samples from a Parisian university hospital center. Results: Of the 87 young physicians (median age 29, 58.6% female) who responded to the survey, 60.3% did not differentiate several standard molecular biology techniques. Median Visual Analog Scale for theoretical knowledge of standard genetic technics was 35/100 (IQR 20-56). Median Visual Analogical Scale for genetics diagnostic and theragnostic indications knowledge were 50/100 (IQR 31.2-70) and 43/100 (IQR 19.2-65), respectively. Proficiency in genetics results interpretation was assessed with a Median Visual Analog Scale of 47/100 (IQR 23.25-69). Finally, 82.4% of young physicians believed that the current teaching of molecular biology was not suited to their current practice and 91.9% requested a specific training implementation. These results were supported by the high rate of nonconformities regarding the prescription (43%) among the different types of nonconformities of genetics samples.Conclusion: Medical education on new techniques of genetics by young French physicians appears to be insufficient, and a specific training should be considered. A better knowledge of this discipline is necessary in order to control the clinical, ethical and financial issues associated with the exponential use of molecular biology in medicine.
Micromachined array-type Mirau interferometer for parallel inspection of MEMS

We present the development of an array type of micromachined Mirau interferometers, operating in the regime of low coherence interferometry (LCI) and adapted for massively parallel inspection of MEMS. The system is a combination of free-space micro-optical technologies and silicon micromachining, based on the vertical assembly of two glass wafers. The probing wafer carries an array of refractive microlenses, diffractive gratings to correct chromatic and spherical aberrations and reference micro-mirrors. The semitransparent beam splitter plate is based on the deposition of a dielectric multilayer, sandwiched between two glass wafers. The interferometer matrix is the key element of a novel inspection system aimed to perform parallel inspection of MEMS. The fabricated demonstrator, including 5 × 5 channels, allows consequently decreasing the measurement time by a factor of 25. In the following, the details of fabrication processes of the micro-optical components and their assembly are described. The feasibility of the LCI is demonstrated for the measurement of a wafer of MEMS sensors.
Globalization, international transport and the global environment: Technological innovation, policy making and the reduction of transportation emissions

This article evaluates the opportunities and the feasibility of technological innovations in transport systems in relation to goals of mitigating global air pollution and climate change. The analytical framework for this technological assessment is formed by the life cycle theory, in which technological innovations are related to the development phase of a transport system (introduction, growth, maturity and decline). Based on a discussion on the driving forces for technological development within the different modes of transport spearheads for technological innovations are being presented. In addition, the role of the government in exerting influence on these development paths is being discussed. The analysis shows that the rate of technological change is slow and the effectiveness of policies to encourage implementation of new transport technologies to reduce emissions on a global scale is limited. Technological innovations can contribute to the reduction of emissions in the international transport sector, but it will be a long term process to generate significant results.
Self-pulsating DFB laser for all-optical clock recovery at 40 Gbit/s

A first demonstration of a 40 Gbit/s all optical clock recovery module based on a design for a novel self-pulsating DFB laser is presented. The role of detuned gratings in the new device concept is evaluated and experimental results of self-pulsation at 40 GHz are reported. The successful locking to 40 Gbit/s optical data signals emphasises the future application in an all-optical 3R-regenerator.
Gamma Radiation Tolerance and Protein Carbonylation Caused by Irradiation of Resting Cysts in the Free-living Ciliated Protist Colpoda cucullus

The ciliate Colpoda cucullus forms resting cysts to survive unfavorable environmental stresses. In this study, we have shown that Colpoda resting cysts survived exposure to a gamma radiation dose of 4000 Gy, although vegetative cells were killed by 500 Gy. After 4000 Gy irradiation, more than 90% of resting cysts and approximately 70% of dry cysts could excyst to form vegetative cells. In both cases, the excystment gradually increased after the induction of excystment. In addition, we also showed that protein carbonylation level was increased by gamma irradiation, but decreased by incubation in the cyst state. These results indicated that cell damage was repaired in resting cysts. Colpoda probably developed tolerance to gamma radiation by forming resting cysts as a strategy for growth in terrestrial environments, as part of contending with the stress due to reactive oxygen species caused by desiccation.
Effect of Channel Estimation Error on Coordinated Small-Cells with Block Diagonalization

This paper investigates the implementation of cooperative communication in small-cells network. Cooperative communication is some cells that in a network can work together, ex. joint transmit power and exchange resource allocation among them. Therefore, cooperative small-cells can be possible to add more multiple input multiple output (MIMO) antennas. But, channel state information (CSI) is required. In practice, perfect channel state information may not be perfect due to the real condition of the real environment such as delay, error, and etc. This paper illustrates cooperative small-cells under error model on the channel estimation. Our propose system is combined by implementing block diagonalization pre-coding and power allocation based on water-filling algorithm. As investigated by simulation results, our proposed coordinated small-cells showed good performances compare to previous algorithm either with perfect channel or with the error channel estimation.
Lumped dynamic model for a bistable genetic regulatory circuit within a variable-volume whole-cell modelling framework

Genetic regulatory circuits (GRCs) including switches, oscillators, signal amplifiers or filters, and signalling circuits are responsible for the control of cell metabolism. Modelling such complex GRCs is a difficult task due to high complexity of the the process (partly known) and the structural, functional and temporal hierarchical organisation of the cell system. Modular lumped representation, grouping some reactions/components and including different types of variables, is a promising alternative allowing individual module characterisation and elaboration of extended simulation platforms for representing the GRC dynamic properties and designing new cell functions. Such models allow to in-silico design modified micro-organisms with desirable properties for practical applications in bioprocess engineering and biotechnology. In the present work, the analysis of a designed bistable switch formed by two gene expression modules is performed in a variable-volume and whole-cell modelling framework, by mimicking the Escherichia coli cell growth. The advantages but also limitations of such a new approach are investigated, by using a Hill-type kinetics combined with few elementary steps, with the aim of better representing the adjustable levels of key intermediates tuning the GRC regulatory properties in terms of stability strength, species connectivity, responsiveness, and regulatory efficiency under stationary and dynamic perturbations.  2009 Curtin University of Technology and John Wiley & Sons, Ltd.
Microwave Measurement of High-Dielectric- Constant Materials

A particularly severe source of error in the microwave measurement of high dielectric constants has been the presence of small air gaps between dielectric surfaces and metal walls. In this paper, two precise measurement techniques are described that eliminate the effect of air gaps through the use of resonant modes, for which E/sub n/=0 at the dielectric-to-metal interface. In one method a cylindrical sample is resonated within a closely fitting circular waveguide, and in the other a cylindrical sample is placed at the center of a radial waveguide. Both methods utilize a circular-electric-mode whose electric field is parallel to the metal walls. The waveguides are dimensioned to be cut off in their air regions at the resonant frequency of the dielectric sample. Formulas yield /spl epsi//sub r/ as a function of the resonant frequency, and of diameter and length of the dielectric cylinder. Measured data on samples having /spl epsi//sub r/ /spl ap/ 85 show the two methods to agree within a few tenths of one percent. The accuracy of the methods is on the order of 0.5 percent maximum error and 0.2 percent probable error when /spl int//sub 0/ is measured within 0.1 percent and D and L within 0.0005 inch (for D/spl ap/ 0.3 inch and L /spl ap/0.1 inch).
A low phase noise oscillator with a high‐Q split ring resonator using MNG metamaterial

In this article, a novel high QL triple‐split ring resonator (T‐SRR) of mu‐negative metamaterial is suggested.It is used in the design of an I‐ band oscillator. A very low phase noise can be obtained for the oscillator due to the sharp band‐rejection characteristic of T‐SRR. The oscillator is designed to operate at 10 GHz using the novel T‐SRR. Experiments show that the output power is 9.82 dBm, the second harmonic suppression is −26.48 dBc, and the phase noise is −105.05 dBc/Hz at a 100‐kHz offset. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:2967–2971, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26404
Mind the gap: Patterns of red blood cell product usage in South Africa, 2014 - 2019.

BACKGROUND A key component of any successful healthcare system is the availability of sufficient, safe blood products delivered in an equitable manner. South Africa (SA) has a two-tiered healthcare system with public and privately funded sectors. Blood utilisation data for both sectors are lacking. Evaluation of blood utilisation patterns in each healthcare sector will enable implementation of systems to bring about more equality. OBJECTIVES To conduct a critical evaluation of red blood cell (RBC) product utilisation patterns at the South African National Blood Service (SANBS). METHODS Operationally collected data from RBC requests submitted to SANBS blood banks for the period 1 January 2014 - 31 March 2019 were used to determine temporal RBC product utilisation patterns by healthcare sector. Demographic patterns were determined, and per capita RBC utilisation trends calculated. RESULTS Of the 2 356 441 transfusion events, 65.9% occurred in the public and 34.1% in the private sector. Public sector patients were younger (median (interquartile range (IQR)) 33 (22 - 49) years) than in the private sector (median (IQR) 54 (37 - 68) years), and mainly female in both sectors (66.2% in the public sector and 53.4% in the private sector). Between 2014 and 2018, per capita RBC utilisation decreased from 11.9 to 11.0/1 000 population in the public sector, but increased from 34.8 to 38.2/1 000 population in the private sector. CONCLUSIONS We confirmed distinctly different RBC utilisation patterns between the healthcare sectors in SA. Possible drivers for these differences may be healthcare access, differing patient populations and prescriber habits. Better understanding of these drivers may help inform equitable public health policy.
Modeling and control of a quadrotor tail-sitter unmanned aerial vehicles

The tail-sitter unmanned aerial vehicles have the advantages of multi-rotors and fixed-wing aircrafts, such as vertical takeoff and landing, long endurance and high-speed cruise. These make the tail-sitter unmanned aerial vehicle capable for special tasks in complex environments. In this article, we present the modeling and the control system design for a quadrotor tail-sitter unmanned aerial vehicle whose main structure consists of a traditional quadrotor with four wings fixed on the four rotor arms. The key point of the control system is the transition process between hover flight mode and level flight mode. However, the normal Euler angle representation cannot tackle both of the hover and level flight modes because of the singularity when pitch angle tends to ± 90 ° . The dual-Euler method using two Euler-angle representations in two body-fixed coordinate frames is presented to couple with this problem, which gives continuous attitude representation throughout the whole flight envelope. The control system is divided into hover and level controllers to adapt to the two different flight modes. The nonlinear dynamic inverse method is employed to realize fuselage rotation and attitude stabilization. In guidance control, the vector field method is used in level flight guidance logic, and the quadrotor guidance method is used in hover flight mode. The framework of the whole system is established by MATLAB and Simulink, and the effectiveness of the guidance and control algorithms are verified by simulation. Finally, the flight test of the prototype shows the feasibility of the whole system.
Study on Optimization of Numerical Simulation for Smooth Blasting Parameters in Xishimen Iron Mine

In order to make normal rock avalanche but not have significant impact on other parts of surrounding rock and produce evident deformation in the process of blasting heading, the basic mechanical property of rocks in Xishimen Iron Mine was taken as example to analyze. The process of coupling charge blasting in the surrounding holes of smooth blasting was simulated by applying the finite element numerical simulation software ANSYS/ LS-DYNA. The result shows that the surrounding rock has smallest stress and spall normally when borehole spacing of surrounding holes is 0.6m, thus boosting the efficiency of smooth blasting.
DRYING OF OIL PALM LUMBER BY COMBINING AIR FORCE DRYING AND MODIFIED SUPERFAST DRYING METHODS

In this study, super-fast drying (SFD) method was modified by adding forced-air drying (AFD) method in the beginning stage. The modified drying method is called modified super-fast drying (MSFD). This method eliminates the holing process in SFD and makes it more favourable by wood-based manufacturers. Inner and outer portion of oil palm lumber (OPL) were segregated and dried using both SFD and MSFD methods. The drying rate and drying defects of the OPL dried with AFD method were compared with conventional air drying (AD) method. The OPL dried with MSFD were compared with SFD in terms of drying defects, rate, physical and mechanical properties. The results revealed that AFD method exhibited significantly effective drying rate compared to AD by shorten the time needed to achieve desired moisture content (MC). On the other hand, MSFD were found to be able to reduce the outer OPL to 10% within 3 hr. The SFD method reported the same rate of drying performance. However, MSFD did not involve the unfavourable holing process as in SFD method. In addition, OPL dried using MSFD exhibited better mechanical and physical properties than SFD. The findings suggested the MSFD method is an enhanced method compared to SFD method.
Suppression of Hole Current in Graphene Transistors with N-Type Doped SiC Source/Drain Regions

To achieve graphene channel transistors which have high on/off drain current ratio and unipolar behavior of drain current – gate voltage (ID-VG) characteristics, we fabricated and characterized the top gated graphene channel transistors with n-type doped SiC source/drain regions. Graphene layer was formed on SiC by high temperature annealing in vacuum, and Al2O3 was used as a gate insulator. For the graphene channel transistor with heavily doped n-SiC source/drain regions (doping concentration ND=4.5x1019cm-3) and a 4~6ML graphene channel, ambipolar behavior was observed. On the other hand, when ND was reduced to 4.5x1018cm-3 and a thin graphene layer was used, the suppression of hole current in ID-VG curve was observed.
Compression Testing of Gypsum-Based Composite Reinforced by Recycled Wires from Automobile Tires

The use of recycled materials is nowadays greatly promoted and these are exploited in many industries, including construction and civil engineering. It is advantageous and efficient to exploit mainly those materials that cannot find their use in any other application. The steel wires from old automobile tires are a perfect example – they can be used as a dispersed reinforcement to stabilize subsoil in railway construction. In order to test the structural performance of the recycled wires as well as the composite behavior, gypsum was chosen a model matrix material. Such approach resulted in a relatively cheap gypsum-based composite material effectively combining gypsum as the material able to resist relatively high levels of compression and recycled wire reinforcement from old automobile tires, which is able to transfer tensile stress. The material can be removed from a formwork after less than 20 minutes of curing and immediately loaded. The study presents the results of a compression test carried out on three different materials – the reference sample was composed of a pure gypsum matrix, while the other two were reinforced by the dispersed wire reinforcement, which has been poorly and perfectly compacted. The results indicate the huge potential of the recycled material for the improvement of soils and brittle materials.
Interaction between Mycodiplosis and Hemileia vastatrix in three scenarios of coffee crop management (Coffea arabica)

La roya del cafeto (Hemileia vastatrix) es una enfermedad devastadora para los cafetales en México. Los métodos de control se han centrado en el uso de fungicidas, pero sin éxito, por lo que el control biológico representa una alternativa. Las larvas de Mycodiplosis se reportan como depredadoras de H. vastatrix, pero la información disponible sobre este insecto es limitada. Los objetivos de esta investigación fueron describir el tipo de relación entre H. vastatrix y Mycodiplosis y conocer su patrón de distribución en el dosel de la planta. Se eligieron tres plantaciones con incidencia de roya en Xochitlán de Vicente Suárez, Puebla y se registraron periódicamente la severidad de la roya y el número de larvas de Mycodiplosis por estrato de la planta. Se seleccionaron 25 plantas por parcela, muestreada en cinco de oros. Las larvas se identificaron molecularmente. Mediante la prueba de Kruskal Wallis, se encontraron diferencias significativas entre sitios de muestreo en la severidad de roya y el número de larvas de Mycodiplosis, detectando una correlación positiva entre la severidad de la roya y el número de larvas de Mycodiplosis. La distribución de Mycodiplosis fue similar en los estratos (baja, media y alta) de las plantas evaluadas.
Mesophilic Digestion of the Organic Fraction of Refuse: Performance and Kinetic Study

The anaerobic digestion of the organic fraction of municipal solid waste sorted by plant was investigated in a 3 m3 stirred digester, operating under mesophilic conditions. Yields of gas obtained at 7 kg total volatile solids per m3 per day and 15-day hydraulic residence time (about 10% biodegradeable solids, 20% total solids) were as much as 1.6 times the digester volume per day. Better sorting should improve the yields which already compare favorably with the existing literature data. A kinetic study on the substrate utilization was performed by employing the "first order" model.
Active high frequency vibration rejection in hard disk drives

This paper presents an active vibration rejection control technique to reject actuator arm resonance modes using a PZT sensor attached to the actuator arm. A multi-rate digital implementation is proposed for high frequency active vibration rejection over the sector induced sampling frequency. The vibration control signal can be synchronized with the slow state feedback control input such that the two control signals are summed and applied to the voice coil motor. After obtaining a transfer function from head position to PZT sensor output, a method is proposed on how to design the vibration rejection controller. An application example demonstrates the utility of the proposed active vibration rejection scheme.
Multi-Scale Modeling and Experimental Validation for Component Fatigue Life Prediction

A fatigue failure prediction procedure is discussed based on a two scale micro meso mechanical model for metallic structures. This model predicts the fatigue life and accounts for physical quantities like the mean stress effect in high cycle fatigue. Another model developed at meso-scale level with BCJ (Bammann, Chiesa and Johnson, 1996, Theoretical and Applied Mechanics, Tatsumi, Watanabe and Kambe (Editors), 359–376) internal state variables, is used to predict progressive damage in ductile materials. This meso-scale model is incorporated within the general purpose finite element software ABAQUS through a user subroutine VUMAT. A lug joint specimen is simulated using the BCJ model modified for fatigue and the location of the crack initiation sites is found. Experiments are conducted with the lug joint specimen under fatigue loading and the models are validated for the fatigue life prediction and location of the damage sites. © 2007 ASME
Investigation of class J continuous mode for high-power solid-state RF amplifier

The class J design space is investigated with half wave current excitation for a solid-state RF amplifier capable of delivering hundreds of watts. Unlike conventional class J designs, the present analysis aims to explore a continuous design space in order to operate a commercially available device, within its practical limits of drain voltage. This design analysis together with package effects and the inclusion of non-linear capacitor is verified experimentally by fabricating a high-power (550 W CW) high-efficiency (62.8%) solid-state amplifier operating at 505.8 MHz. This power was obtained by in-phase combining two similar continuous class J stages, each one contributing half of the total power. For high-power lateral diffused metal-oxide semiconductor devices, the class J design space is found to be more realisable than popular modes of operation in view of the large non-linear output capacitance of the device. The measured output power, efficiency, spurious response and large signal output reflection coefficients are satisfactory and as anticipated from the design analysis. Since the final application of this amplifier is for a solid-state transmitter, a study of repeatability in terms of phase and amplitude imbalances was carried out by fabricating and evaluating multiple amplifiers, each one working with the proposed design principle.