Miracle-dz/UniFAR-FTUs huggingface dataset:
Coarse-to-Fine Aggregation for Cross-Granularity Action Recognition

In this paper, we introduce a novel hierarchical aggregation design that captures different levels of temporal granularity in action recognition. Our design principle is coarse-to-fine and achieved using a tree-structured network; as we traverse this network top-down, pooling operations are getting less invariant but timely more resolute and well localized. Learning the combination of operations in this network - which best fits a given ground-truth - is obtained by solving a constrained minimization problem whose solution corresponds to the distribution of weights that capture the contribution of each level (and thereby temporal granularity) in the global hierarchical pooling process. Besides being principled and well grounded, the proposed hierarchical pooling is also video-length agnostic and resilient to misalignments in actions. Extensive experiments conducted on the challenging UCF-101 database corroborate these statements.
Traffic Efficiency Applications over Downtown Roads

Vehicular network technology is frequently used to provide several services and applications for drivers on road networks. The proposed applications in the environment of road networks are classified into three main categories based on their functions: safety, traffic efficiency, and entertainment. The traffic efficiency services are designed to enhance the moving fluency and smoothness of traveling vehicles over the road network. The grid layout architecture of the downtown areas provides several routes toward any targeted destination. Moreover, since several conflicted traffic flows compete at the road intersections, many vehicles have to stop and wait for safe situations to pass the road intersection without coming into conflict with other vehicles. The traffic efficiency applications in this scenario are designed to select the most efficient path for vehicles traveling toward their targeted destination/destinations. Moreover, other applications aimed to decrease the queuing delay time for vehicles at road intersections. In this article, we review several recently proposed mechanisms that worked to enhance the fluency of traffic over downtown road networks and point to the expected future trends in this field.
Biocatalysis in Polymersomes: Improving Multienzyme Cascades with Incompatible Reaction Steps by Compartmentalization

Incompatibilities encountered in multienzyme syntheses often arise from inhibition or inactivation of individual enzymes by low-molecular-mass compounds. Polymersomes have the tremendous yet unproven potential to enhance the performance of cascade reactions by spatial separation of enzymes from the respective source of incompatibility. A main challenge is the requirement to reduce mass-transport limitations across the polymer membrane with sufficient selectivity to maintain the compartmentalization. We demonstrate that cross-inhibitions in cascade reactions can be avoided by reconstituting highly selective channel proteins into the membrane. Thus, the three-step synthesis of CMP-N-acetylneuraminic acid was improved 2.2-fold compared to the noncompartmentalized reaction.
Intraoperative Physiologic Monitoring During Endovascular Revascularization for Atherosclerotic Peripheral Arterial Disease

Objectives The primary objective of this study is to determine if the magnitude of change of intraoperative toe-brachial index (TBI) during endovascular procedures for atherosclerotic peripheral vascular disease (PVD) is associated with major adverse limb events (MALE) within 1 year postprocedure
Failure analysis method for enhancing circularity through systems perspective

Recently, a circular economy has attracted global attention as an approach for addressing material security and resource‐efficiency issues. As our societies shift toward a circular economy, manufacturers need to not only produce environmentally conscious products but to also realize reliable systems that will ensure the closure of the loops of the products, components, and materials. To do so, early‐stage design is crucial to effectively and efficiently detect possible failures and then take adequate countermeasures against them. Although a few methods of failure analysis have been proposed to address environmental issues, these methods have failed to consider the cause–effect relationships among failures. This will hinder manufacturers from identifying core problems that should be addressed in a given system. Therefore, this study extends failure mode and effect analysis, which is an engineering technique used to address potential failures, by addressing the entire system reliability in relation to circularity. As a result of a case study of a manufacturer aiming to increase circularity with their products on the market, we revealed that the proposed method is useful in the early stage of design to (a) identify failure modes where effects are largely given to or received from other failures, (b) develop countermeasures effectively by addressing root causes of failures, and (c) find an opportunity to collaborate with external actors.
The Determinants Of Happiness: Empirical Evidence Of Java Island

Happiness research on economics has increasingly developed since Easterlin Paradox appeared. This research tries to analyze the determinants of happiness in Java Island, Indonesia. We use data from the Happiness Measurement Survey 2017 conducted by the BPS-Statistic Agency of Indonesia. Taking 23,456 observations, we employ binary logistic regression to test the effects of 13 independent variables on happiness. The results showed that income, education, health, social relations with family and society, environmental conditions, and a meaningful life affect happiness. In general, these findings strengthen some previous studies findings.
Compressed Hyperspectral Pansharpening

Hyperspectral (HS) imaging based on compressed sensing (CS) is actively studied to capture an HS image in one shot. Although CS can reconstruct an HS image from a much less number of random observations, capturing an HS image of high spatial and spectral resolution (HR-HS image) is still difficult because of current imaging systems. In this paper, we propose a new methodology of HS imaging, named compressed HS pansharpening. Specifically, the concept enables to generate an HR-HS image from a compressively-sensed observation with the help of a panchromatic (PAN) image. For a realistic setting, the concept assumes that both a CS observation and a PAN image are contaminated by noise. Then, an HR-HS and a clean PAN image are simultaneously estimated from the noisy pair by solving a newly-formulated optimization problem. In the experiments, we demonstrate the utility of our proposed methodology.
Cladistic analysis of some taxa in Malvaceae s.l. Â“Core MalvalesÂ” based on anatomical characteristics -

Malvaceae s.l. Â“Core MalvalesÂ” which in their broad circumscription include members of four traditional families; Malvaceae s.s. , Bombacaceae, Sterculiaceae and Tiliaceae. The aim of the present study is to evaluate the use of stem, petiole and lamina anatomical characters in analyzing the phylogenetic relationships among 39 studied taxa from Malvaceae s.l. in addition to one representative of Elaeocarpaceae as outgroup through the parsimony analysis using upgraded WinClada and TNT cladistics programs. The anatomy in cross section of stem, petiole and lamina of the 40 studied taxa of Core Malvales were examined by light microscope and photos were taken. The different anatomical characters are discussed and revealed that certain synapomorphic diagnostic characters has great taxonomic values which in turn used for analyzing the phylogenetic relationships between the studied taxa. These characters viz. (petiole outline and vascular system, cuticle thickness, diverse shapes of secondary phloem fibers, presence and types of crystals and trichomes, gossypol gland, resin ducts, tanniferous cells, star-shaped idioblasts, vessels size and distribution, anomalous xylem structure, extrafloral nectaries, .). Our results of the phylogenetic analysis conducted from the cladogram (rooted tree) based on 44 anatomical characters and 111 character states strongly support the monophyly of family Malvaceae s.s. while, the other three families are para- or polyphyletic. It shows, also the graduation of the taxa under study in relation to the outgroup; from Tiliaceae and Sterculiaceae directly attached to the tree (ancestor) while taxa from Bombacaceae and Malvaceae are far away from the root of the tree with little deviation. This indicates that Tiliaceae is the most primitive family followed by Sterculiaceae, Bombacaceae ending recently by the most advanced family Malvaceae. Our results agree to some extent with APG IV classification in transferring Elaeocarpaceae to order Oxalidales instead of Malvales also agree with other worker in transferring Gossypium and Lagunaria in family Sterculiaceae while transferring Dombeya to family Tiliaceae. For more accurate assignment of Malvaceae s.l. still more studies on a large number of taxa are needed.
Capsaicin suppresses breast cancer cell viability by regulating the CDK8/PI3K/Akt/Wnt/β-catenin signaling pathway

Breast cancer displays high morbidity and mortality. Despite exerting certain effects, traditional treatments cannot eliminate every cancer cell and may kill normal cells due to inaccurate targeting. However, as a traditional Chinese medicine, capsaicin, an active compound extracted from chili peppers, has displayed potent anticarcinogenic activities in vitro and in vivo, but the underlying mechanism is not completely understood. The pharmacological effects of capsaicin on tumors was evaluated in MDA MB 231 breast cancer cells. The MTT, cell scratch assay, cell cycle analysis, cell transfection, reverse transcription-quantitative PCR and western blotting were performed to investigate the potential antitumor mechanisms of capsaicin. In the present study, the potential anticancer mechanism underlying capsaicin in MDA-MB-231 cells in vitro was investigated. Capsaicin significantly inhibited MDA-MB-231 breast cancer cell viability and migration compared with the control group. The flow cytometry results indicated that capsaicin induced G2/M cell cycle arrest in MDA-MB-231 cells. In addition, capsaicin significantly reduced the expression of cyclin-dependent kinase 8 (CDK8) in breast cancer cells compared with the control group. Moreover, LV-CDK8 small interfering RNA-transduced MDA-MB-231 cells displayed lower CDK8 mRNA and protein expression levels compared with LV-negative control-shRNA-transduced cells. Furthermore, capsaicin significantly reduced the expression levels of phosphorylated (p)-PI3K, p-Akt, Wnt and β-catenin in vitro compared with the control group. Collectively, the results of the present study suggested that capsaicin inhibited breast cancer cell viability, induced G2/M cell cycle arrest, reduced CDK8 expression levels, decreased the phosphorylation of PI3K and Akt and downregulated Wnt and β-catenin expression levels in MDA-MB-231 cells.
Production of in vitro bovine embryos supplemented with l-carnitine in different oxygen tensions and the relation to nitric oxide

Summary The aim of this study was to evaluate the production of bovine embryos in vitro when supplemented with l-carnitine for 24 h beginning on day 5 (d 5) under two different oxygen tensions (20% or 5%) and the relationship of nitric oxide (NO) in in vitro culture (IVC) medium to embryo development. Cumulus–oocyte complexes (COC; n = 837) were matured in vitro for 24 h and fertilization was performed for 18 h. Zygotes were cultured in vitro for 9 days after in vitro fertilization in synthetic oviductal fluid (SOF) medium with 5% fetal calf serum. At d 5 the plates were assigned to one of four treatment groups: high (20%) or low (5%) O2 tension either with or without the addition of 3.03 mM l-carnitine (High-Cont, High-Lcar, Low-Cont, Low-Lcar). The concentration of NO in the culture medium was evaluated on d 5, d 6 and d 9. On d 7, parts of the embryos were submitted for evaluation of intracellular lipid droplets. The cleavage rate was similar (P > 0.05) between high and low O2 tension and the blastocyst rate was similar in all conditions evaluated. The hatching rate was higher (P < 0.05) for Low-Cont. The NO concentration was higher at d 9 under low O2 tension (P < 0.1). The addition of 3.03 mM l-carnitine between d 5 and d 6 of IVC was not efficient in reducing cytoplasmic lipid content of bovine embryos. Additionally, IVC at a low oxygen tension without l-carnitine promoted better conditions for embryo development. A higher concentration of NO in medium was observed under low O2 tension.
Effect of coating few-layer WS2 on the Raman spectra and whispering gallery modes of a microbottle resonator

Multi-layered tungsten disulfide (WS2) coated silicon/silica (Si/SiO2) substrate and SiO2 micro-bottle resonators (MBRs) have been prepared by van der Waals epitaxy method. Raman spectra of WS2-coated MBR show that the out-of-plane Raman mode is sensitive to the polarization of the excitation laser. The quality factor (Q) values of the whispering gallery modes (WGMs) in the transmission spectrum of an MBR decrease by 2 orders of magnitude on coating with WS2. On coating, a cleaner spectrum is obtained along with a concomitant effect of decrease in the number of lossy modes. Fano resonances as well as Autler-Townes splitting (ATS) was observed for the WGMs in the cleaned transmission spectrum. From the simulations it has been verified that the scattered electric field of the WS2 flakes contributes to the observation of the Fano resonances and ATS in the coated MBR spectra.
A Fast Ray-tracing Method for Locating Mining-Induced Seismicity by Considering Underground Voids

The accurate localization of mining-induced seismicity is crucial to underground mines. However, the constant velocity model is used by traditional location methods without considering the great difference in wave velocity between rock mass and underground voids. In this paper, to improve the microseismicity location accuracy in mines, we present a fast ray-tracing method to calculate the ray path and travel time from source to receiver considering underground voids. First, we divide the microseismic monitoring area into two categories of mediums—voids and non-voids—using a flexible triangular patch to model the surface model of voids, which can accurately describe any complicated three-dimensional (3D) shape. Second, the nodes are divided into two categories. The first category of the nodes is the vertex of the model, and the second category of the nodes is arranged at a certain step length on each edge of the 3D surface model to improve the accuracy of ray tracing. Finally, the set of adjacent nodes of each node is calculated, and then we obtain the shortest travel time from the source to the receiver based on the Dijkstra algorithm. The performance of the proposed method is tested by numerical simulation. Results show that the proposed method is faster and more accurate than the traditional ray-tracing methods. Besides, the proposed ray-tracing method is applied to the microseismic source localization in the Huangtupo Copper and Zinc Mine. The location accuracy is significantly improved compared with the traditional method using the constant velocity model and the FMM-based location method.
Water quality longitudinal profile of the Paraíba do Sul River, Brazil during an extreme drought event

This work addresses the relationships between Land Use/Land Cover (LULC) and water quality in the Paraíba do Sul River (PSR), located in one of the most populated regions in Brazil. We conducted a water sampling program (analyzing nitrate, ammonium, phosphate, turbidity, total carbon, oxygen concentration, and conductivity) during a severe drought period from 2014 to 2016. The 210 samples were spaced about 5 km apart from headwaters to the Atlantic Ocean and taken over 63 d. We calculated a water quality index and applied a self‐organizing map (SOM) to explore the relationship between LULC and water quality. There was a significant influence on water quality from the urban area's socioeconomic profile. This observation reflects the influence of cities with a high population density and a low economic condition, which leads to further degradation and erosion of the riverbanks. The most degraded reservoir of the PSR (Funil) partially buffers these effects by retaining deposited sediments and nutrient loads, leading to downstream water quality improvement. Better management practices of the riverbanks in the lower reach contribute to additional water quality improvements. Three major clusters identified using the SOM had completely different and explainable water quality patterns, suggesting an abrupt change in water quality due to human interventions. This information is crucial to improve management projects for the river at a watershed level, and with the expectation of future water shortages.
Current Trends Of ESRD Patients with Ozonedialysis: Ozone “The Wonder Therapy” For Dialysis

Kavitha D*1, Jeyalakshmi S2, Sridevy S3, Baby Caroline4 1Research scholar, RaniMeyammai College of Nursing, Annamalai University, Chidambaram, Vice Principal, College of Nursing East Coast Institiute of Medical Sciences, Puducherry, India 2Department of Mental health Nursing, RaniMeyammai College of Nursing, Annamalai University, Cuddalore, Tamil Nadu, India 3College of Nursing, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry, India 4East Coast Hospitals, Puducherry, India
Exploratory Study of the Effectiveness of Granulocyte and Monocyte Adsorptive Apheresis Before Initiation of Steroids in Patients With Active Ulcerative Colitis (EXPECT Study): A Multicenter Prospective Clinical Trial

Abstract Background Granulocyte and monocyte adsorptive apheresis (GMA) has been used for therapy of steroid-dependent/refractory ulcerative colitis (UC). The aim of this study was to investigate the effectiveness of GMA in UC patients not receiving steroids. Methods We conducted a single-arm, open-label, and multicenter prospective clinical trial. UC patients who had insufficient responses to 5-aminosalicylic acid received GMA twice a week for 5 weeks. Results The response rate of all patients was 58.2% (39/67). Of the 39 patients who achieved a response, 74.4% achieved endoscopically confirmed mucosal healing. Conclusions GMA shows effectiveness in inducing remission in UC patients not receiving steroid.
MARGE: Mutation Analysis for Regulatory Genomic Elements

Cell-specific patterns of gene expression are determined by combinatorial actions of sequence-specific transcription factors at cis-regulatory elements. Studies indicate that relatively simple combinations of lineage-determining transcription factors (LDTFs) play dominant roles in the selection of enhancers that establish cell identities and functions. LDTFs require collaborative interactions with additional transcription factors to mediate enhancer function, but the identities of these factors are often unknown. We have shown that natural genetic variation between individuals has great utility for discovering collaborative transcription factors. Here, we introduce MARGE (Mutation Analysis of Regulatory Genomic Elements), the first publicly available suite of software tools that integrates genome-wide genetic variation with epigenetic data to identify collaborative transcription factor pairs. MARGE is optimized to work with chromatin accessibility assays (such as ATAC-seq or DNase I hypersensitivity), as well as transcription factor binding data collected by ChlP-seq. Herein, we provide investigators with rationale for each step in the MARGE pipeline and key differences for analysis of datasets with different experimental designs. We demonstrate the utility of MARGE using mouse peritoneal macrophages, liver cells, and human lymphoblastoid cells. MARGE provides a powerful tool to identify combinations of cell type-specific transcription factors while simultaneously interpreting functional effects of non-coding genetic variation.
Identificación de biocatalizadores potenciales para la remediación de desechos petrolizados de la Faja Petrolífera del Orinoco Identification of potential biocatalysts for remediation process of drilling wastes from the Orinoco oil belt

Palabras clave Ripios de perforacion, petroleo, bacteria, Enterobacteriaceae, biorremediacion. The massive exploitation of the Orinoco Oil Belt (OOB), the largest proven reserves of unconventional oil in the world, generates large amounts of drilling wastes that must be managed properly. The aim of this study was to characterize molecularly and functionally the cultivable bacterial community present in drilling wastes mixed with water based drilling fluid of the OOB, to identify potential biocatalysts to be used in bioremediation processes. Eighty-eight bacterial strains were isolated and the morphological and biochemical characterization was initially performed, differentiating their functional activity by cluster analysis. Morphological descriptions revealed that 100% bacteria studied were gram-negative and 71.25% were cocci-bacilli. Biochemistry and functional analysis identified 66 functional groups and 14 groups of functional identity. Molecular studies using the DNA fingerprinting technique indicated the existence of 14 different genotypic groups of bacteria with high hydrocarburoclastic ability and biosurfactants production, which were molecularly identified. The results revealed that the bacteria belong to five (5) different genera: Enterobacter (6; 50%); Pantoea (2; 14,29%); Citrobacter (2; 14,29%); Klebsiella (2; 14,29%) and; Comamonas (1; 7,14%), 92.86% of which correspond to the Enterobacteriaceae family, gamma-proteobacteria class, frequently associated with environments contaminated with hydrocarbons. These bacterial strains were kept at the Bank of Microorganisms of the Department of Energy and Environment from IDEA to be used in future studies as potential biocatalyst in bioremediation process of drilling wastes generated by the oil industry.
NMR characterization of strontium-substituted bioactive glasses and their crystallized glasses

Bioactive glasses have been developed by Hench et al and one of them is now commercially available as Bioglass 45S5 and widely applied in medical fields. [1] Trace amounts of inorganic ions, represented by silicate ions, have been reported to stimulate gene activation and promote bone regeneration [2]. Strontium ions have been also reported to play an important role in bone regeneration in terms of bone metabolism [3]. Since calcium and strontium ions are both divalent cations and have close ionic radius, calcium ion in Bioglass is considered to be readily substituted with strontium ion. And the strontiumcontaining bioactive glasses have been proven to uptake cellular activities and are effective for bone regeneration. [4] In the present work, CaO in the composition of Bioglass 45S5 was substituted with SrO in series. A magic angle spinning nuclear magnetic resonance (MAS-NMR) has been employed to analyse the structures of the strontium-substituted bioactive glasses since it is useful for investigate medium range structure. Understanding the structures of glasses and crystallized glasses is important for further applications such as plasma spray coating onto implant materials. In this work, strontium-substituted bioactive glasses and their crystallized glasses were prepared and their structures were analysed using MAS-NMR.