Miracle-dz/UniFAR-FTUs huggingface dataset:
Preschool children’s inhalation rates estimated from 1 accelerometers—a tool to estimate children’s exposure to air 2 pollution

18 19 20 Children are particularly sensitive to air pollution exposure, and their personal exposures may 21 differ significantly from those of adults. One key factor for understanding the personal 22 dose of air pollutants is the respiratory minute ventilation ( V e ). To estimate the amount of 23 particles circulated through the lungs, 24 h averages of V e are often used. These averages poorly 24 capture variations in V e during the day, and between individuals. We here develop and implement 25 a concept to assess individual V e of children, with minimal impact on their natural activity and 26 movement pattern by using ActiGraph GT3X+ accelerometers. Activity of 136 preschool 27 children in the ages 3 to 5 years was logged using accelerometers while the children attended 28 their preschools during a week. A linear regression equation is developed and used for estimating 29 V e from the accelerometer data retrieved for each individual child. The results show large 30 variations in weekly average V e between individuals, ranging from resolved local air pollution monitoring, these measurements can provide the basis of a more 38 precise estimate of children’s inhaled dose of air pollutants. An alternative methodology to assess V e was suggested in a study of preschool children by Kawahara et al . (2011a; 2011b; 2012). In their studies, pulse loggers and accelerometers were 82 evaluated to estimate V e based on the physical activity of the children. They report a high linear 83 correlation between the accelerometer output and V e (Pearson’s r of 0.913 using a 3-axial accelerometer and 0.886 using a 1-axial accelerometer (Kawahara et al., 2011b)). A similar methodology was also suggested and implemented by Rodes et al. (2012) for adults, where the estimated V e was combined with local variations in the air pollution, also reporting a satisfactory 87 linear correlation between accelerometer output and V e .
Design of smart car section PID control algorithm based on CCD camera

A smart car system based on MC9S12XS128 control was introduced,it used the CCD camera sensor system as a path identification device,pathed through extraction of the black line image recognition information to calculate the shape of the steering response to road traffic control,control of the steering gear.The article on the smart car line-tracking servo control system software design ideas and other ideas of control algorithms were discussed in detail.Test results show that the stability of intelligent vehicle can accurately track the lead black line running,the algorithm can well control the smart car.
Time varying changes and uncertainties in the CMIP6 ocean carbon sink from global to regional 1 to local scale

As a major sink for anthropogenic carbon, the oceans slow the increase of carbon dioxide in the 8 atmosphere and regulate climate change. Future changes in the ocean carbon sink, and its uncertainty at a global 9 and regional scale, are key to understanding the future evolution of the climate. Here, we conduct a multimodel 10 analysis of the changes and uncertainties in the historical and future ocean carbon sink using output data from the 11 latest phase of the Coupled Model Intercomparison Project: CMIP6, and observations. We show that the ocean 12 carbon sink is concentrated in highly active regions - 70 percent of the total sink occurs in less than 40 percent of 13 the global ocean. High pattern correlations between the historical and projected future carbon sink indicate that 14 future uptake will largely continue to occur in historically important regions. We conduct a detailed breakdown of 15 the sources of uncertainty in the future carbon sink by region. Scenario uncertainty dominates at the global scale, 16 followed by model uncertainty, and then internal variability. We demonstrate how the importance of internal 17 variability increases moving to smaller spatial scales and go on to show how the breakdown between scenario, 18 model, and internal variability changes between different ocean basins, governed by different processes. Moreover, 19 we show that internal variability changes with time based on the scenario. As with the mean sink, we show that 20 uncertainty in the future ocean carbon sink is also concentrated in the known regions of historical uptake. The 21 resulting patterns in the signal-to-noise ratio have strong implications for observational detectability and time of 22 emergence, which varies both in space and with scenario. Our results suggest that to detect human influence on the 23 ocean carbon sink as early as possible, and to efficiently reduce uncertainty in future carbon uptake, modelling and 24 observational
Brief communication: The crucial assessment of possible significant vertical movements preceding the 28 December 1908, Mw = 7.1, Messina Straits earthquake

Abstract. The 28 December 1908 Messina Straits earthquake represents one of the worst seismic catastrophes in world history. In spite of the relatively large and various amount of data available and the geophysical investigations accomplished in the straits, the seismogenic structure is still elusive and intensely debated. Some models proposed for the causative fault rely considerably on the hypothesis of significant subsidence preceding the event. By driving results that differ critically from previously debated models, this assumption would have crucial repercussions on the seismic hazard assessment in the area. However, the critical analysis of this assumption in the light of the available data allows the rejection of this possibility.
A Large-scale and Longitudinal Measurement Study of DKIM Deployment

DomainKeys Identiﬁed Mail (DKIM) is an email authentication protocol to protect the integrity of email contents. It has been proposed and standardized for over a decade and adopted by Yahoo! , Google, and other leading email service providers. However, little has been done to understand the adoption rate and potential security issues of DKIM due to the challenges of measuring DKIM deployment at scale. In this paper, we provide a large-scale and longitudinal measurement study on how well DKIM is deployed and managed. Our study was made possible by a broad collection of datasets, including 9.5 million DKIM records from passive DNS datasets over ﬁve years and 460 million DKIM signatures from real-world email headers. Moreover, we conduct an active measurement on Alexa Top 1 million domains. Our measurement results show that 28.1% of Alexa Top 1 million domains have enabled DKIM, of which 2.9% are mis-conﬁgured. We demonstrate that the issues of DKIM key management and DKIM signatures are prevalent in the real world, even for well-known email providers (e.g., Gmail and Mail.ru). We recommend the security community should pay more attention to the systemic problems of DKIM deployment and mitigate these issues from the perspective of protocol de-sign.
Evidence for Mitochondria! Localization of yV-(4-Methylphenylsulfonyl)-jY'-(4-chlorophenyl)urea in Human Colon Adenocarcinoma Cells

A44-Methylphenylsurfonyl)-/V'-(4-chlorophenyl)urea (MPCU) is a new agent that exhibits high therapeutic activity against human and rodent tumor models. Initial studies indicated that in vitro |'II|MI'< I was concentrated 4- to 6-fold in GCj/Ci human colon adenocarcinoma cells in an azide-sensitive manner. In this study the dependence of uptake and concentrative accumulation of MPCU upon temperature, plasma membrane potential, and the electrochemical potential of mitochondria has been examined. Accumulation and efflux of MPCU were temperature dependent. At 3.6 MMMPCU, initial rates of uptake (15 s) were 1.4, 38.0, and 84.2 pmol/min/10" cells at 2Â°C,23Â°C,and 37Â°C,respectively. The rate of uptake and concentrative accumulation within GCi/Ci cells was not altered in high k* buffer or by 1 HIMouabain, indicating that plasma membrane potential was not significant in these processes. Con centrative accumulation, but not initial uptake, was inhibited by carbonyl cyanide p-trifluoromethoxyphenylhydrazone, 2,4-dinitrophenol, and so dium azide. Glucose partially antagonized the inhibition of these agents which uncouple oxidative phosphorylation. Oligomycin, an inhibitor of mitochondria! ATP synthase, did not inhibit uptake or concentrative accumulation of MPCU. However, oligomycin in the presence of 2-deoxyglucose significantly inhibited concentrative accumulation of MPCU. These results suggested that concentrative accumulation of MPCU was dependent upon the mitochondria! transmembrane gradient rather than ATP, although direct implication of ATP could not be excluded. To examine which component of this gradient was predominant in causing MPCU sequestration, the ionophores valinomycin and nigericin were used. Valinomycin, which collapses the charge gradient across the mitochondria! matrix membrane, caused only slight inhibition of MPCU accumulation, and the effect was similar at 2 or 10 ^mol. In contrast, nigericin (which collapses the pH gradient and increases mito chondria! membrane potential) inhibited by -90% concentrative accu mulation of MPCU. These data suggested that MPCU was being con centrated in mitochondria and that this was dependent upon the pH gradient across mitochondria! membrane. In cells exposed to MPCU or the analogue A'-(5-indanylsulfonyl)-A'/-(4-chlorophenyl)urea, enlarge ment of mitochondria was observed within 24 h and appeared to be the initial morphological change associated with drug treatment. These re sults implicate mitochondria as a site of sequestration of diarylsulfonylureas and as a potential site of action.
Significant underestimation of peatland permafrost along the 1 Labrador Sea coastline 2

Northern peatlands cover approximately four million km², and about half of these peatlands are estimated to contain 8 permafrost and periglacial landforms, like palsas and peat plateaux. In northeastern Canada, peatland permafrost is predicted 9 to be spatially concentrated in the western interior of Labrador and largely absent along the Labrador Sea and Gulf of St. 10 Lawrence coastline. However, the paucity of observations of peatland permafrost in the interior, coupled with ongoing use of 11 perennially frozen peatlands along the coast by Labrador Inuit and Innu, casts doubt on the reliability of existing maps of 12 peatland permafrost distribution in the region. In this study, we develop a multi-stage consensus-based inventory of peatland 13 permafrost complexes in coastal Labrador and adjacent parts of Quebec using high-resolution satellite imagery and validate it 14 with extensive field visits and low-altitude aerial photography and videography. A total of 1885 wetland complexes were 15 inventoried, of which 1023 were interpreted as likely containing peatland permafrost. Likely peatland permafrost complexes 16 were mostly found in lowlands within 40 km of the coastline where mean annual air temperatures of up to +1.2 °C are recorded. 17 Evaluation of the geographic distribution of peatland permafrost complexes reveals a clear gradient from the outer coasts, 18 where peatland permafrost is more abundant, to inland peatlands, where permafrost is generally absent. This coastal gradient 19 may be attributed to a combination of climatic and geomorphological influences which lead to lower insolation, thinner 20 snowpacks, and more frost-susceptible materials along the coast. The results of this study also suggest that existing maps of 21 permafrost distribution for southeastern Labrador require adjustment to better reflect the abundance of peatland permafrost 22 complexes which are located to the south of the regional sporadic discontinuous permafrost limit. This study constitutes the 23 first dedicated peatland permafrost inventory for Labrador, and our results provide an important baseline for future mapping, 24 modelling, and climate change adaptation strategy development in the region. like vegetation cover, surficial geology, and glacial lake and marine
STUDY ON THE EFFECT OF ALGINATE, TYPE OF CROSS LINKERS, AND MUCOADHESIVE POLYMERS ON DRUG RELEASE FROM LOVASTATIN-LOADED MUCOADHESIVE CROSS-LINKED MICROBEADS

Objective: The aim of the current study is to prepare and lovastatin-loaded alginate microbeads were prepared using emulsification gelation internal method by the use of different cross-linking agents, polymer effect in different concentrations on drug release and its combination with hydrophilic polymers on drug release. Methods: The effect of sodium alginate concentration and its combination with other hydrophilic polymers on particle size and shape, scanning electron microscopy (SEM) studies, entrapment efficiency, Fourier transform infrared (FTIR) analysis (FTIR), differential scanning calorimetry (DSC) studies, and X-ray diffraction (XRD) studies conducted to determine compatibility of drug and used excipients and in vitro drug release was studied. The efficiency of mucoadhesion strength of microbeads is determined by wash-off study. Results: The optimum condition for preparation alginate beads and produces sustained release manner was occurred at 3% polymer mixture. Infrared spectroscopic study confirmed the presence of compatibility between drug-polymer additives, good drug entrapment, and SEM studies prove microbeads were in spherical and rough particles. XRD and DSC were used to confirm successful entrapment of drugs into the alginates microbeads. The in vitro release profile could be altered notably by changing formulation parameters to give a sustained release of drug from the microbeads. Conclusion: The kinetic modeling of the release data indicate that drug release from the microbeads follow anomalous transport mechanism and super Case-II transport mechanism and drug release is controlled by both swelling and relaxation of the polymer chains. The release of drug from formulation is pH dependent. This will help in overcoming the drawbacks of lovastatin with a short half-life, improves the bioavailability. The release kinetics of drug from the alginate beads followed zero order. optimized formulation, and targeted drug delivery to a specific site or a particular organ in the body. The effects of the polymer concentration, effect of various curing agents, encapsulation efficiency, effect of hydrophilic polymers on drug release, and release kinetics were also investigated. The ionotropic gelation technique was selected to prepare controlled release lovastatin alginate beads due to its easy accessibility, low economical, and its success with poor aqueous solubility drugs and the production of cross-linked beads.
Capture-Recapture Reveals Heterogeneity in Habitat-Specific Mongoose Densities and Spatiotemporal Variability in Trapping Success in St. Kitts, West Indies

Abstract The small Indian mongoose (Urva auropunctata) is a non-native invasive species across the Caribbean and a rabies reservoir on at least four islands in the region. Although previous studies reported mongoose density estimates in their non-native range, the variability in trapping designs, study seasonality, and analytical methods among studies precludes direct comparisons. This study is the first to report mongoose densities for the island of St. Kitts, West Indies. Our objective was to quantify mongoose densities across four habitats characteristic for the island. High capture and recapture rates in this study resulted in detailed estimates of spatial heterogeneity in mongoose densities, ranging from 0.53 (CI95: 0.46–0.61) mongooses/ha in suburban habitat to 5.85 (CI95: 4.42–7.76) mongooses/ha in nearby dry forest. Estimates were robust to the estimation method used (correlation among methods, r > 0.9). Female-biased sex ratios estimated from fall season versus mostly unbiased sex ratios estimated from summer season suggests seasonality in capture success resulting from differences in sex-specific activity patterns of mongooses. We found no effect of habitat characteristics, at the scale of trap placements, associated with mongoose capture success.
The role of urban planning in climate adaptation: an empirical analysis of UHI in European cities

This paper empirically analyses the relationship between urban form and Urban Heat Island (UHI) in a dataset of 523 European cities that matches remotely sensed land-use and surface temperature data. A UHI anomaly is defined as an uninterrupted streak of days where the temperature differential measured at 12.00 AM between the city core and its surroundings is higher than a given threshold. From this definition, three UHI indicators are obtained: mean intensity, mean duration of the event and occurrence rate. We study the influence of urban morphology on the UHI indictors with a Heckman model. A sample selection bias is detected for mean intensity and mean duration. The estimation results also show that some urban morphological features have a mitigating effect, while some others play a role at the adaptation level.
Automated tuning, control and stabilization of photonic integrated circuits

The complexity scaling of silicon photonics circuits is raising novel needs related to control. Reconfigurable architectures need fast, accurate and robust procedures for the tuning and stabilization of their working point, counteracting temperature drifts originated by environmental fluctuations and mutual thermal crosstalk from surrounding integrated devices. In this contribution, we report on our recent achievements on the automated tuning, control and stabilization of silicon photonics architectures. The proposed control strategy exploits transparent integrated detectors to monitor non-invasively the light propagating in the silicon waveguides in key spots of the circuit. Local monitoring enables the partitioning of complex architectures in small photonic cells that can be easily tuned and controlled, with need for neither preliminary circuit calibration nor global optimization algorithms. The ability to monitor the Quality Of of Transmission (QoT) of the optical paths in Photonic Integrated Circuits (PICs) is also demonstrated with the use of channel labelling and non-invasive light monitoring. Several examples of applications are presented that include the automatic reconfiguration and feedback controlled stabilization of an 8×8 switch fabric based on Mach-Zehnder interferometers (MZIs) and the realization of a wavelength locking platform enabling feedback-control of silicon microring resonators (MRRs) for the realization of a 4×10 Gbit/s wavelength-division-multiplexing transmitter. The effectiveness and the robustness of the proposed approach for tuning and stabilization of the presented architectures is demonstrated by showing that no significant performance degradation is observed under uncooled operation for the silicon chip.
International Journal of Scientific Research in Science and Technology

174 Systematic Review on Therapeutic Applications of Yeast ‘Saccharomyces’ Olivia Mondal1, Devanshi Khanna2, Shalja Panwar3, Shilpa Negi4, Sneha Basu5 1School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Sciences, Jadavpur, Kolkata, India 2Clinical Research Department, School of Biosciences (SBS), Apeejay Stya University, PalwalSohna Road, Gurugram, India 3Centre of Excellence Laboratory, Department of Biochemistry and Plant Physiology, College of Biotechnology, Sardar Vallabhbhai Patel University of Agriculture & Technology, Meerut, India 4Department of Zoology, HNB Garhwal University, Uttarakhand, India 5Department of Biotechnology, SRM University, SRM Nagar, Kattankulathur, India
Third Degree Price Discrimination with Externality in Cournot Oligopoly

Firms often ﬁnd it proﬁtable to segment customers according to their demand sensitivity and to price discriminate accordingly. In some settings, consumer heterogeneity can be directly observed, and a ﬁrm can base its pricing upon contractible consumer characteristics. In this context, the presente dissertation analyses olipolistic third-degree price discrimination in the presence of consumption externalities within female and male markets. Assuming linear inverse demands, we investigate an associated change in social welfare (the sum of the consumers’ surpluses and the producer’s proﬁt) with the regime change from uniform pricing to price discrimination when both markets are open under either regime. It is shown that social welfare and men’s consumer surlus does not is unaﬀected by the regime change. However, women’s consumer surplus increases with price discriminated.
OpenIFS/AC: atmospheric chemistry and aerosol in OpenIFS 43r3

Abstract. In this paper, we report on the first implementation of atmospheric chemistry and aerosol as part of the European Centre for Medium-Range Weather Forecasts (ECMWF) OpenIFS model. OpenIFS is a portable version of ECMWF's global numerical weather prediction model. Modules and input data for model cycle CY43R3, which have been developed as part of the Copernicus Atmosphere Monitoring Service (CAMS), have been ported to OpenIFS with the modified CB05 tropospheric chemistry scheme, the bulk bin tropospheric aerosol module, and the option to use Belgian Assimilation System for Chemical ObsErvations (BASCOE)-based stratospheric ozone chemistry. We give an overview of the model, and describe the datasets used for emissions and dry deposition, which are similar to those used in the model configuration applied to create the CAMS reanalysis. We evaluate two reference model configurations with and without the stratospheric chemistry extension against standard observational datasets for tropospheric ozone, surface carbon monoxide (CO), tropospheric nitrogen dioxide (NO2), and aerosol optical depth. The results give basic confidence in the model implementation and configuration. This OpenIFS version with atmospheric composition components is open to the scientific user community under a standard OpenIFS license.
A novel Mean Teacher framework for domain adaptive lung registration

Recent deep learning-based registration models achieve excellent results but require plenty of labeled training data and suffer from domain shifts between training and test data. As a remedy, we present a novel method for domain adaptive image registration. We propose to reduce the domain shift through self-ensembling and embed a keypoint-based registration model into the Mean Teacher paradigm. We extend the Mean Teacher to the registration problem by 1) adapting the stochastic augmentation scheme and 2) combining learned feature extraction with differentiable optimization. This enables us to guide the learning process in the unlabeled target domain by enforcing consistent predictions of the learning student and the temporally averaged teacher model. We evaluate the method for exhale-to-inhale lung CT registration under two challenging adaptation scenarios. Our method consistently improves on the baseline model by 44 %/47 % while even matching the accuracy of models trained on target data. Source code is available at https://anonymous.4open. science/r/reg-da-mean-teacher.
A comparison of the effects of a chlamydial vaccine administered during or 1 after a C. muridarum urogenital infection of female mice. 2

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