Miracle-dz/UniFAR-FTUs huggingface dataset:
Validity and Reliability of the Arabic Version of the Copenhagen Neck Functional Disability Scale in Neck Pain Patients

Study Design Prospective observational study. Purpose To test the face validity, content validity, feasibility, internal consistency, reliability, and test–retest reliability of the Arabic version of the Copenhagen Neck Functional Disability Scale (CNFDS). Overview of Literature CNFDS is a clinical evaluation tool that accurately reflects the patient’s perception regarding his/her functionality with existing cervical pain. This study aimed to investigate the validity and reliability of the Arabic version of the CNFDS in measuring the disability level in chronic neck pain patients. Method Seventy-four patients with neck pain were recruited, and 135 sheets (test and retest sheets) were completed by patients; two expert panels (each comprising ten experts) participated in this study. Arabic translation (forward translation), development of the preliminary translated version, English translation (backward translation), development of the prefinal version, and testing of the prefinal version was performed by experts; thereafter, the final version was tested on patients. Index of clarity, expert proportion of clearance, index of content validity (CVI), expert proportion of relevance, descriptive statistics, missed item index, Cronbach’s alpha, and Spearman’s rank correlation coefficient were used for statistical analyses. Results The study revealed that the scale index of clarity was 86.84%, scale CVI was 99.33%, scale-level content validity index (universal agreement method) was 99.33%, 99.15% of the scale items were filled in all sheets, the scale was answered in less than 3 minutes in about 75% cases, Cronbach’s alpha was 0.856 (0.796, 0.905), and all Spearman’s correlations between the test and retest results were statistically significant. Conclusions The Arabic version of the CNFDS has adequate validity and reliability for the measurement of the disability level in chronic neck pain patients.
High-speed analogue sampled-data signal processing for real-time fault location in electrical power networks

The emulation of low-loss or lossless one-dimensional (1D) or 2D transmission mediums using analogue sampled-data signal processing is presented. Based on discrete-time wave propagation simulation, transmission lines are emulated with many elementary identical delay elements, implemented by simple equivalent switched-capacitor (SC) circuits. The accuracy and limitations of this discrete time model are studied in the frame of power network fault location using electromagnetic time-reversal principle. The sensitivities to non-ideal effects usually plaguing analogue CMOS SC circuits, such as amplifier finite open-loop gain, offset, and parasitic charge injection due to clock feedthrough, are evaluated in the same context. It is shown that the SC line emulation is well suited to the presented fault location technique and considerably reduces the fault location time (by a factor up to 100) in comparison to standard digital solutions, allowing fault location resolutions of typically 1% within a few hundred milliseconds. These expectations are confirmed by measurements realised on the presented line model integrated-circuit, implemented in an AMS 0.35 μm CMOS process. The speed improvement obtained through the presented method is essential, potentially allowing real-time fault management in power grids.
Developmental stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors

Significance Retinoblastoma is a childhood tumor that forms in response to mutations in the RB1 gene and loss of functional RB protein. Prior studies suggested that retinoblastomas arise from cone photoreceptor precursors, whereas mouse models yield tumors deriving from other retinal cell types and lacking human retinoblastoma features. We show that in cultured human retinae, retinoblastomas initiate from RB-depleted cone precursors that are in a specific maturation state and form premalignant retinomas prior to retinoblastoma lesions, as is believed to occur in retinoblastoma patients. In contrast, Rb-deficient mouse cone precursors of similar maturation state and supplemented with human cone precursor-specific oncoproteins fail to proliferate. Thus, human species-specific developmental features underlie retinoblastoma genesis and may challenge the production of accurate retinoblastoma models. Most retinoblastomas initiate in response to the inactivation of the RB1 gene and loss of functional RB protein. The tumors may form with few additional genomic changes and develop after a premalignant retinoma phase. Despite this seemingly straightforward etiology, mouse models have not recapitulated the genetic, cellular, and stage-specific features of human retinoblastoma genesis. For example, whereas human retinoblastomas appear to derive from cone photoreceptor precursors, current mouse models develop tumors that derive from other retinal cell types. To investigate the basis of the human cone-specific oncogenesis, we compared developmental stage-specific cone precursor responses to RB loss in human and murine retina cultures and in cone-specific Rb1-knockout mice. We report that RB-depleted maturing (ARR3+) but not immature (ARR3−) human cone precursors enter the cell cycle, proliferate, and form retinoblastoma-like lesions with Flexner–Wintersteiner rosettes, then form low or nonproliferative premalignant retinoma-like lesions with fleurettes and p16INK4A and p130 expression, and finally form highly proliferative retinoblastoma-like masses. In contrast, in murine retina, only RB-depleted immature (Arr3−) cone precursors entered the cell cycle, and they failed to progress from S to M phase. Moreover, whereas intrinsically highly expressed MDM2 and MYCN contribute to RB-depleted maturing (ARR3+) human cone precursor proliferation, ectopic MDM2 and Mycn promoted only immature (Arr3−) murine cone precursor cell-cycle entry. These findings demonstrate that developmental stage-specific as well as species- and cell type-specific features sensitize to RB1 inactivation and reveal the human cone precursors’ capacity to model retinoblastoma initiation, proliferation, premalignant arrest, and tumor growth.
Measurement invariance of the SF-12 among different demographic groups: The HELIUS study

Aim To investigate whether items of the SF-12, widely used to assess health outcome in clinical practice and public health research, provide unbiased measurements of underlying constructs in different demographic groups regarding gender, age, educational level and ethnicity. Methods We included 23,146 men and women aged 18–70 of Dutch, South-Asian Surinamese, African Surinamese, Ghanaian, Turkish, or Moroccan origin from the HELIUS study. Both multiple group confirmatory factor analyses (MGCFA), with increasingly stringent model constraints (i.e. assessing Configural, Metric, Strong and Strict measurement invariance (MI)), and regression analysis were conducted to establish comparability of SF-12 items across demographic groups. Results MI regarding gender, age and education was tested in the ethnic Dutch group (N = 4,615). In each subsequent step of testing MI, change in goodness-of-fit measures did not exceed 0.010 (RMSEA) or 0.004 (CFI). Moreover, goodness-of-fit indices showed good fit for strict invariance models: RMSEA<0.055; CFI>0.97. Regarding ethnicity, RMSEA values of metric and subsequent models fell above 0.055, indicating violation of measurement invariance in factor loadings, thresholds and residual variances. Regression analysis revealed possible age-, education- and ethnicity-related DIF. Adjustment for this DIF had little impact on the magnitude of age and educational differences in physical and mental health, but ethnic inequalities in physical health–and to a lesser extent mental health—were reduced after DIF adjustment. Conclusions We found no evidence of violation of measurement invariance of the SF-12 regarding gender, age and educational level. If minor DIF would remain undetected in our MGCFA analyses, we showed that this would have negligible effect on the magnitude of demographic health inequalities. Regarding ethnicity, the SF-12 was not measurement invariant. After accounting for DIF, we observed a reduction of ethnic inequalities in health, in particular in physical health. Caution is warranted when comparing SF-12 scores across population groups with various ethnic backgrounds.
Long-Term Antipsychotic Effectiveness in First Episode of Psychosis: A 3-Year Follow-Up Randomized Clinical Trial Comparing Aripiprazole, Quetiapine, and Ziprasidone

Abstract Background Different effectiveness profiles among second-generation antipsychotics may be a key point to optimize treatment in patients suffering a first episode of psychosis to affect long-term outcome. The aim of this study was to compare the clinical effectiveness of aripiprazole, ziprasidone, and quetiapine in the treatment of first episode of psychosis at 3-year follow-up. Method From October 2005 to January 2011, a prospective, randomized, open-label study was undertaken. Two hundred-two first-episode, drug-naïve patients were randomly assigned to aripiprazole (n=78), ziprasidone (n =62), or quetiapine (n=62) and followed-up for 3 years. The primary effectiveness measure was all cause of treatment discontinuation. In addition, an analysis based on the intention-to-treat principle was conducted in the analysis for clinical efficacy. Results The overall dropout rate at 3 years reached 19.3%. Treatment discontinuation rates were significantly different among treatment groups (aripiprazole=73.08%, ziprasidone=79.03%, and quetiapine=95.16%) (χ2=11.680; P=.001). Statistically significant differences in terms of nonefficacy, nonadherence, and side effects were observed among treatment groups along the 3-year follow-up determining significant differences in time to all-cause discontinuation (log-rank=32.260; P=.001). Significant differences between treatments were found in the categories of sleepiness/sedation (χ2=9.617; P=.008) and increased sleep duration (χ2=6.192; P=.004). No significant differences were found in the profile of extrapyramidal symptoms. Patients on aripiprazole were more likely to be prescribed benzodiazepines. Conclusions First-episode psychosis patients on quetiapine were more likely to discontinue treatment due to nonefficacy. Identifying different discontinuation patterns may contribute to optimize treatment selection after first episode of psychosis.
Ultrastructure of the bone marrow of the salamander Plethodon glutinosus (Caudata: Plethodontidae)

The unusual lymphogranulopoietic bone marrow of the large lungless salamander Plethodon glutinosus was examined by light and electron microscopy. Developing neutrophils, eosinophils, and fat cells were found in large numbers, while lymphocytes of various sizes, plasma cells, plasmablasts, macrophages, pigment cells, and fibroblasts were present in more moderate numbers. Basophils were observed only rarely. Macrophages were found in extravascular locations and did not appear to be associated directly with the walls of the blood vessels supplying the marrow. Both neutrophils and eosinophils seemed to arise from small precursor cells whose ultrastructural features bore a resemblance in some ways to those of mammalian myeloblasts described by Bainton and Farquhar ('66). Developing neutrophils and eosinophils seemed to produce only single populations of specific cytoplasmic granules, rather than both primary (azurophilic) and secondary (specific) inclusions, as are produced typically by mammalian granulocytes. Both eosinophilic and neutrophilic granules were formed in association with Golgi complexes; and eosinophilic granules were much larger, more densely stained, and more regularly rounded in shape than the inclusions of developing neutrophils. Peroxidase activity was associated with the specific granules of neutrophils but seemed to be lacking in the granules of eosinophils. The specific granules of eosinophils were especially unusual because they contained irregularly shaped, lightly stained cores which occasionally displayed a distinctly crystalline substructural organization. The specific granules of basophils also possessed a prominent crystalline organization. The overall appearance of the marrow of Plethodon suggests that it functions not only as a valuable source of neutrophils, eosinophils, and cells of the lymphoid series, but also as a part of the phagocytic system of the animals and as an important repository for fat.
Traceable ciphertext-policy attribute-based encryption scheme with attribute level user revocation for cloud storage

In a ciphertext-policy attribute-based encryption (CP-ABE) scheme, a user may have multiple attributes, and each attribute may be shared simultaneously by many users. The decryption key of an attribute can thus be shared by many users who all possess the attribute. For monetary gain, a malicious authorized user may reveal his/her decryption key to a third party, and it is difficult to trace the owner of primitive secret key from an exposed key. At the same time, this situation may also limit commercial applications of CP-ABE systems. To solve these problems and enable fine-grained access control for the encrypted data, we propose a traceable CP-ABE scheme with attribute-level user revocation for cloud storage (TUR-CPABE). Our scheme enjoys four advantages. First, it has the ability to trace malicious users who have leaked key information from the system. Second, it supports attribute-level user revocation for malicious users and allows ABE fine-grained access control. Third, it allows secret key updates and ciphertext updates to resist collusion attacks between users. Fourth, outsourcing encryption, decryption and attribute revocation are used to reduce the computational burden on data owners, data users and the trust authority, respectively. In addition, our scheme has been proven to be secure against chosen plaintext attacks under a selective access policy based on decisional q – BDHE assumption in the standard model.
Semantically Enhanced Models for Commonsense Knowledge Acquisition

Commonsense knowledge is paramount to enable intelligent systems. Typically, it is characterized as being implicit and ambiguous, hindering thereby the automation of its acquisition. To address these challenges, this paper presents semantically enhanced models to enable reasoning through resolving part of commonsense ambiguity. The proposed models enhance in a knowledge graph embedding framework for knowledge base completion. Experimental results show the effectiveness of the new semantic models in commonsense reasoning.
Time-related eating patterns and chronotype are associated with diet quality in pregnant women

ABSTRACT Animal studies strongly suggest that timed feeding can have beneficial physiological effects, including protection against the obesogenic and metabolic consequences of a high-fat diet. However, the relationship between variables related to the timing of eating and diet quality in pregnancy women, which is considered as a period of nutritional vulnerability, is still poorly described in the literature. Therefore, the aim of the present study was to investigate the associations between time-related eating patterns and chronotype with diet quality of pregnant women. This cross-sectional study was conducted with 100 pregnant women in the first gestational trimester (≤12 weeks of gestation). The information regarding food intake was obtained by three 24-Hour Dietary Recall (24HR). Time-related eating patterns, i.e., the interval between the first and the last meal (eating duration), nightly fasting, time of the first and last meals, and number of meals eating on a day were determined. Chronotype was derived using the mid-sleep time on free days on weekends, with a further correction for calculated sleep debt. Diet quality was evaluated using the Brazilian Healthy Eating Index-Revised (BHEI-R), validated for the Brazilian population. Linear regression modeling analyses adjusted for confounders were used to investigate the association between time-related eating patterns and chronotype with diet quality. The BHEI-R total score was negatively associated with time of the first meal (β = −0.355; p = 0.002; r2 adjusted = 0.141), and positively associated with eating duration (β = 0.262; p = 0.024; r2 adjusted = 0.086) and number of meals (β = 0.273; p = 0.019; r2 adjusted = 0.091). In addition, the score of total fruit component was negatively associated with chronotype (β = −0.236; p = 0.033; r2 adjusted = 0.078), time of the first meal (β = −0.393; p = 0.001; r2 adjusted = 0.171), and positively associated with eating duration (β = 0.259; p = 0.022; r2 adjusted = 0.087) and number of meals (β = 0.376; p = 0.001; r2 adjusted = 0.159). The score for whole fruit component was negatively associated with time of the first meal (β = −0.388; p = 0.001; r2 adjusted = 0.152), and positively associated with number of meals (β = 0.403; p = 0.001; r2 adjusted = 0.164). A longer eating duration, earlier time of the first meal, higher number of meals and morningness tendency are associated with a better diet quality in the first gestational trimester – higher scores of the total BHEI-R and/or fruit components. We suggest that nutritional guidelines should consider time-related eating patterns and chronotype to ensure good diet quality of pregnant women since the beginning of gestation, contributing on prevention of metabolic-nutritional complications.
In vivo conversion of astrocytes into oligodendrocyte lineage cells with transcription factor Sox10; Promise for myelin repair in multiple sclerosis

Recent studies demonstrate that astroglial cells can be directly converted into functional neurons or oligodendrocytes. Here, we report that a single transcription factor Sox10 could reprogram astrocytes into oligodendrocyte-like cells, in vivo. For transdifferentiation, Sox10-GFP expressing viral particles were injected into cuprizone-induced demyelinated mice brains after which we assessed for the presence of specific oligodendrocyte lineage cell markers by immunohistofluorescence (IHF). As control, another group of demyelinated mice received GFP expressing viral particles. After 3 weeks, the majority of transduced (GFP+) cells in animals which received control vector were astrocytes, while in animals which received Sox10-GFP vector, the main population of GFP+ cells were positive for oligodendrocyte lineage markers. We also extracted primary astrocytes from mouse pups and purified them. Primary astrocytes were transduced in vitro and then transplanted into demyelinated brains for later fate mapping. After three weeks, in vitro transduced and then transplanted astrocytes showed oligodendrocyte progenitor and mature oligodendrocyte markers. Further confirmation was done by transduction of astrocytes with lentiviral particles that expressed Sox10 and GFP and their culture in the oligodendrocyte progenitor medium. The induced cells expressed oligodendrocyte progenitor cells (iOPCs) markers. Our findings showed the feasibility of reprogramming of astrocytes into oligodendrocyte-like cells in vivo, by using a single transcription factor, Sox10. This finding suggested a master regulatory role for Sox10 which enabled astrocytes to change their fate to OPC-like cells and establish an oligodendroglial phenotype. We hope this approach lead to effective myelin repair in patients suffering from myelination deficit.
A tailless aerial robotic flapper reveals that flies use torque coupling in rapid banked turns

Flying fast and free Insect flight can be fast and agile, making it hard to study its detailed aerodynamics. Karásek et al. designed an untethered, flapping-wing robot with impressive agility that can mimic fruitfly maneuvers (see the Perspective by Ruffier). They studied the robot's motion during rapid banked turns, which revealed that passive motion through the turn generated yaw torque coupling. This correcting yaw rotation propelled the robot toward the escape heading needed for effective turning. Science, this issue p. 1089; see also p. 1073 An untethered, flapping-wing robot with impressive agility is capable of mimicking maneuvers of the fruitfly. Insects are among the most agile natural flyers. Hypotheses on their flight control cannot always be validated by experiments with animals or tethered robots. To this end, we developed a programmable and agile autonomous free-flying robot controlled through bio-inspired motion changes of its flapping wings. Despite being 55 times the size of a fruit fly, the robot can accurately mimic the rapid escape maneuvers of flies, including a correcting yaw rotation toward the escape heading. Because the robot’s yaw control was turned off, we showed that these yaw rotations result from passive, translation-induced aerodynamic coupling between the yaw torque and the roll and pitch torques produced throughout the maneuver. The robot enables new methods for studying animal flight, and its flight characteristics allow for real-world flight missions.
11C-acetate and 18F-fluorodeoxyglucose positron emission tomography/computed tomography dual imaging for the prediction of response and prognosis after transarterial chemoembolization

Abstract The aim of the present study was to evaluate the clinical significance of dual radiotracer studies, 11C-acetate and 18F-fluoro-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT), for the prediction of response and recurrence after transarterial chemoembolization (TACE). This study retrospectively included a total 42 hepatoceullar carcinoma (HCC) patients (median age, 59; range, 34–85 years old) who underwent 11C-acetate and 18F-FDG PET/CT concurrently. Tumor uptake normalized by liver uptake (TNR; maximum tumor SUV to mean normal liver SUV ratio) was obtained first. Then, FAratio, which is the ratio of 18F-FDG TNR (TNR_FDG) to 11C-acetate TNR, was obtained and correlated with response after TACE and recurrence-free survival (RFS), using a Cox multivariate proportional-hazard model. Among clinical factors, including the Hepatoma Arterial Embolization Prognostic score and positron emission tomography (PET) parameters, multiple regression analysis revealed FAratio and tumor size to be the only significant factors. As a PET parameter, FAratio exhibited the largest area under the curve in the prediction of response after TACE. In the Cox multivariate proportional-hazard model, TNR_FDG was the only significant predictive factor for RFS. In subgroup analysis, TNR_FDG was the only significant predictive factor for recurrence in intermediate stage patients. However, FAratio was the only significant predictive factor for recurrence in advanced stage patients. Dual radiotracer use of 11C-acetate and 18F-FDG PET/CT contributed to the prediction of response and recurrence after TACE. Used in addition to 18F-FDG, 11C-acetate PET/CT could give additional information in advanced stage patients. Based on the characteristics of tumor metabolism assessed by dual radiotracer PET/CT, treatment plans could be more personalized and optimized.