Miracle-dz/UniFAR-FTUs huggingface dataset:
Bioenergetic Crosstalk between Mesenchymal Stem Cells and various Ocular Cells through the intercellular trafficking of Mitochondria

Rationale: Mitochondrial disorders preferentially affect tissues with high energy requirements, such as the retina and corneal endothelium, in human eyes. Mesenchymal stem cell (MSC)-based treatment has been demonstrated to be beneficial for ocular degeneration. However, aside from neuroprotective paracrine actions, the mechanisms underlying the beneficial effect of MSCs on retinal and corneal tissues are largely unknown. In this study, we investigated the fate and associated characteristics of mitochondria subjected to intercellular transfer from MSCs to ocular cells. Methods: MSCs were cocultured with corneal endothelial cells (CECs), 661W cells (a photoreceptor cell line) and ARPE-19 cells (a retinal pigment epithelium cell line). Immunofluorescence, fluorescence activated cell sorting and confocal microscopy imaging were employed to investigate the traits of intercellular mitochondrial transfer and the fate of transferred mitochondria. The oxygen consumption rate of recipient cells was measured to investigate the effect of intercellular mitochondrial transfer. Transcriptome analysis was performed to investigate the expression of metabolic genes in recipient cells with donated mitochondria. Results: Mitochondrial transport is a ubiquitous intercellular mechanism between MSCs and various ocular cells, including the corneal endothelium, retinal pigmented epithelium, and photoreceptors. Additionally, our results indicate that the donation process depends on F-actin-based tunneling nanotubes. Rotenone-pretreated cells that received mitochondria from MSCs displayed increased aerobic capacity and upregulation of mitochondrial genes. Furthermore, living imaging determined the ultimate fate of transferred mitochondria through either degradation by lysosomes or exocytosis as extracellular vesicles. Conclusions: For the first time, we determined the characteristics and fate of mitochondria undergoing intercellular transfer from MSCs to various ocular cells through F-actin-based tunneling nanotubes, helping to characterize MSC-based treatment for ocular tissue regeneration.
A Robust Predictive Model for Stock Market Index Prediction using Data Mining Technique

- Prediction of stock market index is very challenging task for investors to invest the currency. The main objective of investors are invest the currency and make profit. This research work explores to develop the robust predictive model which predicts the correct foresting with minimum error. In this research work we have used machine learning techniques like Classification and Regression Technique (CART), CHAID, Artificial Neural Network (ANN) and Support Vector Machine (SVM) for analysis and prediction of BSE SENSEX data. The ANN gives the better prediction with very less Mean Absolute Error (MAE) and Mean Absolute Percentage Error (MAPE). We have also extend the experimental work and analyzed the ANN predictive model with different learning rate and achieved less error measures like MAE =0.0044 and MAPE= 0.676 with 0.9 learning rate and 1 hidden layer.
Protective Effect of Cochlospermum tinctorium A. Rich Extract versus Aflatoxin B Induced Liver Damage in Rats

AbstractPretreatment of rats with the extract of an African plant Cochlospermum tinctorium A. Rich (36 mg/ kg, p.o.) prior to aflatoxin B, (AFB1) provided partial protection against AFB1-− induced liver damage determined 72 hr after AFB1 challenge (1.5 mg/kg, i.p.). Pretreatment with the extract resulted in a significant reversal of the AFB1-− induced elevation of the activities of sorbitol dehydrogenase (SDH) and serum glutamic pyruvic transaminase (SGPT), but the elevation of serum glutamic oxalacetic transaminase (SGOT) was reversed only slightly. Although the extract did not afford a statistically significant protection against the toxin-induced depression of microsomal cytochrome P-450, the protection of microsomal benzphetamine N-demethylase and aniline hydroxylase was significant. These results provide a basis for initiating studies on isolation and characterization of the active component(s) of the extract for possible therapeutic use against hepatitis.
Environmental and molecular regulation of phenazine-1-carboxamide biosynthesis in Ppseudomonas chlororaphis strain PCL1391

The biocontrol strain studied in this thesis is Pseudomonas chlororaphis strain PCL1391, which controls tomato foot and root rot caused by Fusarium oxysporum f. sp. radicis-licopersici (Chin-A-Woeng et al., 1998). Production of the anti-fungal metabolite phenazine-1-carboxamide (PCN) and an efficient root colonizing ability (Chin-A-Woeng et al., 2000) are crucial for efficient biocontrol by P. chlororaphis strain PCL1391. This thesis aims at the identification and analysis of environmental conditions affecting the production of PCN and the identification of novel genes involved in the regulation of PCN production.
A SUB-MAXIMAL ECCENTRIC TRAINING COUPLING WITH EURYCOMA LONGIFOLIA JACK SUPPLEMENTATION INDUCED QUADRICEPS MUSCULAR STRENGTH AND THICKNESS IN YOUNG ELITE RUGBY PLAYERS

Eurycomalongifolia Jack (ElJ) contains a useful organic compound proprietary for various medical purposes and was reported to able to stimulate the androgen hormones such as testosterone. However, its use for enhancing training and sports performance was unclear. Therefore, this study aimed to examine the effects of consuming ElJ supplementation when implementing submaximal eccentric training on quadriceps muscular strength and muscle thickness in elite athletes. Sixteen young elite rugby sevens players (21.5±1.5years; 1.74±0.06m; 80. 0±10.kg) were randomly assigned to one of two groups that supplemented with either ElJ (400mg per day) or similar taste and appearance placebo (PLA). They performed a submaximal eccentric training 3 times a week for 6 weeks in which the load increased from 75% to 100% of concentric 1RM (5% increase/week). Dependent variables of one repetition maximum (1RM) concentric and eccentric strength during leg press; concentric and eccentric peak torque at speeds of 60°/s and 180°/s during isokinetic knee extension and flexion, respectively; isometric peak torque and muscle thickness (vastus medialis, vastus lateralis, and rectus femoris) were collected within a week prior to, and after the 6-week training period, and then analysed accordingly. Mixed ANOVA indicated a significant interaction was evidenced for concentric 1RM (p = 0.018). Significant changes (p < 0.05) for pre and post-test were detected for concentric and eccentric 1RM, peak torque at 60°/s and 180°/s (with the exception for concentric peak torque at 180°/s), isometric peak torque, and muscle thickness of the vastus medialis, vastus lateralis, and rectus femoris; however, no between-group differences were found. The results indicated that combined ElJ supplementation and eccentric sub-maximal training induced significant improvement of quadriceps strength and quadriceps muscle thickness in young elite rugby players.
MPPTRACKER FOR PV SYSTEM USING REMOTE LOGGER

---------------------------------------------------------------------***--------------------------------------------------------------------Abstract The main aim behind this paper is to detect the losses in the middle of usage of our PV energy by solar panel. Here we introduce a maximum-powerpoint-tracking (MPPT) controller for a photovoltaic (PV) energy conversion system. Nowadays, PV generation is more and more used as a renewable energy source. Maximum power point tracking (MPPT) must usually be integrated with photovoltaic (PV) power systems so that the photovoltaic arrays are able to deliver the maximum power available. Here we uses a Voltage sensor to sense the voltage and current values coming from the pv system and these are integrated to the microcontroller to detect the faulty systems. Here we are using a battery to store the voltage and current coming from the panel and stored for external usage and also connected for a load. Thus, the MPPT (Maximum Power Point Tracking Technique) together with the battery energy storage is necessary in order to obtain a stable and reliable maximum output power from a PV generation system. Here we are using a remote data logger to obtain the information about the performance of the solar panel by comparing the results coming out from the pv system.
The Input to Verb Learning in Japanese: Picture Books for Syntactic Bootstrapping

This study investigates the feasibility of syntactic bootstrapping in a radical argument drop language, Japanese. Previous studies propose that children use syntactic cues (e.g., the number of arguments) to infer the meanings of novel verbs in a process known as syntactic bootstrapping (e.g., Landau & Gleitman, 1985; Gleitman, 1990; Naigles, 1990; Fisher et al., 2010). For syntactic bootstrapping to work, the syntactic cues must be observable in the input. However, these cues are frequently absent in Japanese child-directed speech (Rispoli, 1995; Matsuo et al., 2012), which raises questions as to whether the syntactic bootstrapping is a viable strategy to learn verb meanings in Japanese. In Japanese, argument noun phrases and post-nominal case markers that typically signal grammatical relations to verbs may be omitted if they are recoverable from the context, as in (1) (Kuroda, 1965; Kuno, 1972). The case marker is always omitted when the argument is omitted but not vice versa.
Electrospray Plume Evolution Via Discrete Simulations

The University of California, Los Angeles (UCLA) Plasma & Space Propulsion Laboratory (PSPL) has developed an Interaction Model which simulates electrospray droplet dynamics immediately following emission through expansion into a plume. Simulation results offer insight into plume expansion as the culmination of fundamental physics governing charged droplet motion. This publication emphasizes the role of velocity differences between droplets in provoking clustering events with resulting large-magnitude Coulombic interactions that facilitate plume expansion. Simulated plume profiles show the propensity of smaller, highspecific charge droplets to occupy wide plume angles, and heavier, low-specific-charge droplets to remain near the axis of emission. Plume profile results demonstrate a high sensitivity to the modal distribution of the droplet population, motivating further research on droplet emission and breakup processes.
Population status of the Bornean orang-utan Pongo pygmaeus in a vanishing forest in Indonesia: the former Mega Rice Project

Abstract As peat-swamp forests in Borneo become progressively more fragmented, the species that inhabit them are increasingly threatened, notably the Endangered Bornean orang-utan Pongo pygmaeus. The area of a failed agricultural project known as the Mega Rice Project in Central Kalimantan, Indonesia, is composed of fragments of peat-swamp forest that are reported to contain orang-utans, although no comprehensive survey has previously been conducted. In a portion of this area we identified remaining forest fragments, using satellite imagery, and surveyed line transects for orang-utan sleeping nests to determine the density, abundance and distribution of the species. The total area of peat-swamp forest in the study area is 76,755 ha, 59,948 ha of which comprises patches at least as large as the home range of a female orang-utan (250 ha). We estimate a mean population density of 2.48 ± SE 0.32 individuals km−2 and a population of 1,700 ± SE 220 or 1,507 ± SE 195 individuals, based on a 25 and 250 ha minimum patch size threshold, respectively. This is c. 40–45% of the original population, and the fragmented population is unlikely to be viable in terms of long-term demographic and genetic stability. To ensure persistence of this population of orang-utans, direct conservation action to connect forest fragments and prevent further loss of peat-swamp forest will be required, including re-establishing the hydrological regime, reforesting barren areas and fighting fires.
cASpER: A Plug-in for Automated Code Smell Detection and Refactoring

During software evolution, code is inevitably subject to continuous changes that are often performed by developers within short and strict deadlines. As a consequence, good design practices are often sacrificed, possibly leading to the introduction of sub-optimal design or implementation solutions, the so-called code smells. Several studies have shown that the presence of code smells makes the source code more change- and fault-prone, reduces productivity, and causes greater rework and more significant design efforts for developers. Refactoring is the practice that developers may use to remove code smells without changing the external behavior of the source code. However, it requires much time and effort and is poorly automated, often leading developers to prefer keeping low-quality code instead of spending time in designing and performing refactoring operations. To mitigate this problem and support developers throughout the process of code smell identification and refactoring, in this paper we present cASpER, a IntelliJ IDEA plugin that provides visual and semi-automatic support for detection and refactoring four different types of code smells. Tool. Jetbrains: https://plugins.jetbrains. com/plugin/13659-casper Video. https://youtu.be/HBWF8fFJM8s
Granulomatous inflammations in the intestine of Pelophylax ridibundus (Anura: Ranidae) caused by Brandesia turgida (Plathelminthes: Digenea)

The report provides data on granulomatous inflammation in the small intestine of Pelophylax ridibundus, observed in exophytic outgrowths (diverticulums) of duodenum and caused by Brandesia turgida. Amphibians were collected from Protected Areas (Privolzhskaya Lesostep’ State Nature Reserve, Penza region, and Sosnovaya Roscha Forest Park near the town Yoshkar-Ola) during the field seasons of 2011–2018. An histological examination was made according to standard histological procedures; we used hematoxylin and eosin stain. The trematode Brandesia turgida was found not only in the Lieberkühn glands, but also in the serosa. Noncaseating epithelioid granulomas were localised in the serosa. Macrophages and single multinuclear PirogovLanghans giant cells were also detected in the serosa. Granular decay, puckering of nuclei and nuclear detritus were detected. Marked leukocyte infiltration with a significant predominance of eosinophils was observed. The periphery of such granulomas can be characterised by a lymphohistiocytic profile. Mycobacterial infection was not detected. The obtained data describe a new case of granulomatous inflammation in amphibians.
THE EVOLUTION OF TOTAL SOLUBLE PROTEINS CONTENT DURING THE GERMINATION OF GLYCINE MAX L. L. BEANS UNDER THE INFLUENCE OF SOME RHIZOBACTERIAL STRAINS

Utilization of rhizobacteria in order to increase the productivity may be a viable alternative to organic fertilizers. The main goal is to reduce the pollution and to preserve the environment in the spirit of an ecological agriculture. Because soybean represent a crop of major economic importance, a study was performed to analyze the impact of some rhizobacteria isolated from soybean roots on the on the germination process of Glycine max L. beans, taking into account the total soluble protein content and germination rate. The results showed that in the early stages, rhizobacteria has an inhibitory effect on the germination process.
PART OF SPEECH TAGGER FOR ARABIC TEXT BASED SUPPORT VECTOR MACHINES: A REVIEW

There is not much research that discusses the Part of speech (POS) tagger for the Arabic language. Hence, the Arabic language is challenging to identify the types of part of the speech of a particular word in a given context because most modern texts do not use diacritical marks. Hence, one word could spell in several different ways. Also, the distinction between the differences in the Arab derivatives is a complicated issue, so the clarification of the correct types on the POS requires the use of different resources and advanced processing. Therefore, the study of part of the speech can contribute to literature and progress in the signs of the Arabic language. The POS is employed in different fields of natural languages processing such as text translation, and extraction, text classification and identifies the type of speech. Identifying unique POS tags for the Arabic language is a difficult task. This paper aims to review the implementation of support vector machines (SVM) for utilizing the POS for the Arabic Language. Therefore, the primary objectives of this paper are to summarize and organize the works for tagging the Arabic text based on SVM automatically and efficiently for motivating and guiding researchers to do more research on the online applications for the Arabic language.
University of Groningen The impact of older person's frailty on the care-related quality of life of their informal caregiver over time Oldenkamp,

Purpose To examine the impact of changes in an older person’s frailty on the care-related quality of life of their informal caregiver. Methods Five research projects in the TOPICS-MDS database with data of both older person and informal caregiver at baseline and after 12 months follow-up were selected. Frailty was measured in five health domains (functional limitations, psychological well-being, social functioning, health-related quality of life, self-rated health). Care-related quality of life was measured with the Care-Related Quality of Life instrument (CarerQoL-7D), containing two positive (fulfilment, perceived support) and five negative dimensions (relational problems, mental health problems, physical health problems, financial problems, problems combining informal care with daily activities). Results 660 older person/caregiver couples were included. Older persons were on average 79 (SD 6.9) years of age, and 61% was female. Caregivers were on average 65 (SD 12.6) years of age, and 68% was female. Results of the multivariable linear and logistic regression analyses showed that an increase in older person’s frailty over time was related to a lower total care-related quality of life of the caregiver, and to more mental and physical health problems, and problems with combining informal care with daily activities at follow-up. A change in the older person’s psychological well-being was most important for the caregiver’s care-related quality of life, compared to the other health domains. Conclusions Health professionals observing decreasing psychological well-being of an older person and increasing hours of informal care provision should be aware of the considerable problems this may bring to their informal caregiver, and should tailor interventions to support informal caregivers according to their specific needs and problems.
UPDATING THE LINEAR DECODER FOR THE UPLINK IN MIMO SYSTEM USING SVD ALGORITHM IN LINEAR DETECTION

: MIMO (multi input multi output) has its limitation, because of that many researcher have developed a massive MIMO system. In linear detector massive MIMO system one of the main problem is placed on Uplink in MIMO system, because Massive MIMO system have to deal with huge matrix inversion to find approximate transmitted data. Because of this, we are trying to find new way to approximate transmitted data while reducing the complexity in the inverse huge matrix. In this paper, we are using SVD (Singular Value Decomposition) for two common linear detection which is Zero Forcing and Minimum Mean-Square Error (MMSE). To fulfil that, SVD algorithm when updating one user join or leave the base station, Given Rotation and GolubReinsch algorithm applied. If we need to minimalize the error, we have to redundant the reinsch algorithm. The trade-off of redundant the Reinsch algorithm is the complexityis higher. But still, the complexity is less than Neumann series and the exact inversion.
The ecology and natural history of a fishing mouse Chibchanomys spec. nov. (Ichthyomyini: Muridae) from the Andes of Southern Ecuador

Information is presented on the habitat, diet, biogeography and conservation requirements of a species of Chibchanomys from the Andes of southern Ecuador. Naturally rare, it is a paramo stream-Hving species which is probably primarily a predator on aquatic macroinvertebrates, supplemented with fish. The eyes are reduced, the vibrissum and its nerves highly developed. Observations on a captive individual suggest touch has supplanted vision in food location in this species. Occuring at 4 000 m, this Chibchanomys is one of the highest-Hving members of its family. Along it a number of other vertebrates, invertebrates and plants, this rodent is restricted to the Cajas Plateau. Threats to the survival of it and the other endemic biota of the plateau are outUned.
Effect of Ascorbic Acid and Cysteine Hydrochloride on Growth of Bifidobacterium Bifidum

The effects of ascorbic acid and L-cysteine hydrochloride (Cys-HCl) on growth of Bifidobacterium bifidum BB01 and BB03 were studied by using MRS broth as the control, the concentrations of ascorbic acid and Cys-HCl were both of 0.4, 0.6, 0.8, 1.0 and 1.2g/L. The result showed as follows: ascorbic acid 0.8g/L or Cys-HCl 0.6g/L on growth of B. bifidum BB01 and ascorbic acid 0.4g/L and Cys-HCl 0.4g/L on growth of B. bifidum BB03 had significant influence (p p
Alleviation of salt stress by Halomonas sp. and osmolytes in Zea mays

Level of osmolytes accumulation to a variable extent in bacteria and plants is associated with the salt tolerance. We hypothesized that two previously isolated salt tolerant strains, Halomonas meridiana (PAa6) and Halomonas aquamarina (RT2), found to stimulate the growth of wheat also have the ability to accumulate osmolytes. These strains can favour plant growth due to their endogenous osmolyte accumulation. To ascertain this, strains were checked for osmolyte accumulation under salt stress. Growth and osmolyte accumulation of inoculated and non-inoculated seeds of the economically significant plant, Zea mays Var. EV.90, was recorded. Seeds were sown in soil supplemented with and without exogenous proline and glycine betaine and salt stress for 15 days. The results show that strains can accumulate osmolytes (preferably glycine betaine) at higher salt stress. Inoculation and exogenous osmolytes (10 mM) improved the plant growth at higher salt stress. However, concurrent application had an amplified effect. Endogenous level of osmolyte (preferably glycine betaine) on the fresh weight basis was significantly higher and improved bacterial and plant growth under stress. We conclude that accumulation of osmolytes in bacteria and plants significantly stimulated growth and protect them from the adverse effect of salt stress. This can be an alternate economic approach to increase crop productivity. Key words : Osmolyte, glycine betaine, proline, salt stress.