Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Bardoxolone Methyl on Hepatic Enzymes in Patients with Type 2 Diabetes Mellitus and Stage 4 CKD

In a multinational placebo‐controlled phase III clinical trial in 2,185 patients with type 2 diabetes mellitus and stage 4 chronic kidney disease, treatment with the Nrf2 activator bardoxolone methyl increased estimated glomerular filtration rate, a measure of kidney function, but also resulted in increases in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma glutamyl transferase. These increases in liver enzyme level(s) were maximal after 4 weeks of treatment and reversible, trending back toward baseline through week 48. Total bilirubin concentrations did not increase, and no cases met Hy’s Law criteria, although two subjects had ALT concentrations that exceeded 10 × the upper limit of the population reference range leading to discontinuation of treatment. Animal and cell culture experiments suggested that the increases in ALT and AST induced by bardoxolone methyl may be related to its pharmacological activity. Bardoxolone methyl significantly induced the mRNA expression of ALT and AST isoforms in cultured cells. Expression of ALT and AST isoforms in liver and kidney also positively correlated with Nrf2 status in mice. Overall, these data suggest that the increases in ALT and AST observed clinically were, at least in part, related to the pharmacological induction of aminotransferases via Nrf2 activation, rather than to any intrinsic form of hepatotoxicity.
Antibiotic resistant pattern of isolated bacteria from Obere River in Orile-Igbon, Oyo State, Nigeria

Good quality water must be odourless, colourless, tasteless and free from pathogens. This is adversely affected when it is polluted beyond certain limits. Potable water for domestic use should however be free of pathogenic organisms. Water samples were collected from Obere River in Orile-lgbon, Oyo state, Nigeria in order to study the antibiotic resistance pattern of isolated bacteria. The bacteria genera detected were Pseudomonas, Bacillus, Proteus and Flavobacterium. The isolates were subjected to antibiotic sensitivity test with about 90% showing multiple antibiotic resistance. All the isolates have a high resistance rate (100%) against amoxicillin, augmentin (100%), streptomycin (95%), chloramphenicol (95%) and ceftriaxone (90%); while, the least resisted antibiotics was ciprofloxacin (35%). It was concluded that Obere River in Orile-Igbon, Oyo State is polluted with pathogenic bacteria showing multiple antibiotic resistance. Thus, there is need for proper treatment of water in this study area before distribution for consumption and general domestic usage. Key words: Water samples, Obere River, antibiotic sensitivity test, multiple antibiotic resistance.
ACTIVE DEPENDENCY FORMATION IN ISLANDS: HOWGRAMMATICAL RESUMPTIONAFFECTS SENTENCE PROCESSING MAAYAN KESHEV

Previous studies concluded that despite the parser’s eagerness to resolve filler-gap dependencies, in island configurations it prefers to posit late grammatical gaps over early ungrammatical ones. This study investigates the possibility of resolving filler-gap dependencies inside Hebrew islands. We investigated the acceptability of resumptive pronouns (RPs) in two islands and the sensitivity of on-line dependency formation to the status of those RPs. Results revealed a filled-gap effect inside the island that allows RPs but not inside the one that prohibits them. This suggests that active dependency formation can proceed inside islands, and that when processing dependencies with islands, the Hebrew parser prefers an early RP over a later gap. *
383-393 PIECEWISE-LINEAR PROGRAMMING AND MULTICOMMODITY TRANSPORT FLOWS PROBLEM

The paper deals with a piecewise-linear programming problems with a nonseparable objective function and a finite method for solving them. The idea of the method is based on the extension of the idea of the simplex method to a class of non-separable piecewise-linear problems. It secures finding of a local solution to the problem after a finite number of iterations. The idea is applied to solve the multicommodity flow problems with a piecewise-linear cost function. The pecularities of the flow problem constraints make it possible to decompose the matrix of constraints into smaller ones and thus to diminish the volume of calculations. The method disregards the objective function convexity and continuity. AMS Subject Classification: 90C35
Deep Equatorial Ocean Circulation Induced by a Forced–Dissipated Yanai Beam*

A complex pattern of zonal currents below the thermocline has been observed in the equatorial Pacific and Atlantic Oceans. The currents have typical speeds from 10 to 15 cm s and extend as deep as 2500 m. Their structure can be divided into two overlapping parts: the equatorial deep jets (EDJs), centered on the equator and alternating in the vertical with a wavelength of several hundred meters, and the Equatorial Intermediate Current system (EICS), composed of currents with large vertical scale and alternating with latitude over several degrees on either side of the equator. The strongest EICS current is a westward flow on the equator flanked by eastward currents at 28N and 28S. In the present study, the authors use idealized numerical simulations and analytical solutions to demonstrate that the EICS currents within 2.58 from the equator could result from the self-advection with dissipation of a downward-propagating beam of monthly periodic Yanai (Rossby gravity) waves. The zonally restricted beam is generated in the eastern part of the basin by instabilities of the swift near-surface equatorial currents. For a weak Yanai wave amplitude and no dissipation, mean Eulerian currents resembling the three strongest EICS currents are obtained but only within the beam; in this case, the Eulerian flow is balanced by the waveinduced Stokes drift, yielding a zero-mean Lagrangian flow, and the water parcels conserve their potential vorticity (PV) and are stationary over a wave cycle. For larger amplitudes, the Yanai waves break, losing their energy to small vertical scales where it is dissipated. This dissipation changes the mean (wave averaged) PV of a water parcel within the beam, allowing the parcel to have a persistent equatorward drift across PV contours. This can be viewed as a wave-induced Sverdrup transport; by continuity and by virtue of the westward group velocity of long Rossby waves, this Lagrangian-mean meridional flow requires a Lagrangian-mean zonal flow within and to the west of the beam, with a meridional structure consistent with the three strongest EICS currents. This mechanism of EICS formation is active in some ocean general circulation models; its importance in the ocean remains to be evaluated.
MOTORIZED BACKCOUNTRY RECREATION AND STRESS RESPONSE IN MOUNTAIN CARIBOU (Rangifer tarandus caribou)

Mountain caribou (Rangifer tarandus caribou) are endangered in British Columbia and motorized backcountry recreation has been identified as a potential threat to their persistence. My objective was to test if fecal glucocorticoids (GCs), indicative of physiological effects of ecological stress in wildlife, could be used as a non-invasive tool to quantify stress response in free-ranging caribou exposed to motorized recreation. I validated an enzyme-linked immunosorbent assay (ELISA) to measure concentration of fecal GCs for R. tarandus using an adrenocorticotropic hormone (ACTH) challenge experiment on captive reindeer exposed to extreme variation in winter weather. Female reindeer expressed elevated fecal GCs 9-11 hrs after ACTH injection. Males showed no detectable increase, perhaps due to underdosing. Fecal GCs varied markedly in both sexes in response to natural variation in weather. Overall, my results indicated fecal assays can be used to track biologically meaningful changes in adrenal activity in R.
Recherche de similarité thématique en temps réel au sein d’un débat en ligne (Thematic similarity real-time computation during an online debate)

Cet article se focalise sur l’utilisation d’un large réseau lexico-sémantique français pour le calcul de similarité thématique d’interventions au cours d’un débat en ligne dans les lycées, proche du temps réel. Pour cela, notre système extrait des informations sémantiques du réseau et crée à la volée des vecteurs enrichis pour chaque fragment de texte. Les données récupérées sont contextualisées via un algorithme de propagation. Les vecteurs résultat permettent aux fragments de texte d’être comparés. Notre méthode aide à trouver les thématiques émergentes des débats et à identifier des clusters d’opinion. La contrainte temps réel nous force à sélectionner précisément les informations que nous incluons, aussi bien pour les temps de calcul des vecteurs créés que la qualité de ceux-ci.
Analyse automatique en cadres sémantiques pour l’apprentissage de modèles de compréhension de texte (Semantic Frame Parsing for training Machine Reading Comprehension models)

Dans le cadre de la compréhension automatique de documents, cet article propose une évaluation intrinsèque et extrinsèque d’un modèle d’analyse automatique en cadres sémantiques (Frames). Le modèle proposé est un modèle état de l’art à base de GRU bi-directionnel, enrichi par l’utilisation d’embeddings contextuels. Nous montrons qu’un modèle de compréhension de documents appris sur un corpus de triplets générés à partir d’un corpus analysé automatiquement avec l’analyseur en cadre sémantique présente des performances inférieures de seulement 2.5% en relatif par rapport à un modèle appris sur un corpus de triplets générés à partir d’un corpus analysé manuellement.
Design to Value: a smart asset for smart products

Rising commodity prices, consolidating supply markets and ongoing economic pressures are making it difficult for consumer goods companies to maintain margins. Many input costs have more than doubled over the last year, driven by rapid growth in emerging markets, which is fueling an ever-increasing need for raw materials and creating a growing mismatch between demand and supply. In addition, consolidating supplier markets have tipped the competitive balance in favor of suppliers and limited CPG companies’ ability to fight price increases. Consumers, under tremendous pressure from the economic downturn, are significantly reducing their purchases or trading down to lower cost products. As a result, companies are having a hard time passing on rising costs to consumers through price increases. Combined, these three forces are creating a perfect storm that threatens the profitability of CPG companies.
ZAGREB INDICES AND COINDICES OF PRODUCT GRAPHS

For a (molecular) graph, the first Zagreb index M1 is equal to the sum of squares of the degrees of vertices, and the second Zagreb index M2 is equal to the sum of the products of the degrees of pairs of adjacent vertices. Similarly, the first and second Zagreb coindices are defined as M1(G) = P uv / ∈E(G) (dG(u) + dG(v)) and M2(G) = P uv / ∈E(G) dG(u)dG(v). In this paper, we compute the Zagreb indices and coindices of strong, tensor and edge corona product of two connected graphs. We apply some of our results to compute the Zagreb indices and coindices of open and closed fence graphs.
ImageNet performance correlates with pose estimation robustness and generalization on out-of-domain data

Neural networks are highly effective tools for pose estimation. However, robustness to out-of-domain data remains a challenge, especially for small training sets that are common for real-world applications. Here, we probe the generalization ability with three architecture classes (Mo-bileNetV2s, ResNets, and EfﬁcientNets). We developed a novel dataset of 30 horses that allowed for both “within-domain” and “out-of-domain” (unseen horse) benchmarking - this is a crucial test for robustness that current human pose estimation benchmarks do not directly address. We show that better ImageNet-performing architectures perform better on both within-and out-of-domain data if they are ﬁrst pretrained on ImageNet. Our results demonstrate that transfer learning is bene-ﬁcial for out-of-domain robustness.
Angst Management Technology

Now a day’s people are intolerable to their senses and feelings. There are n number of categories in feelings they even differs according to each and every person personality and character . One among these feelings is Anxiety caused by Adrenaline Hormone ,which can creates worst scenarios on lacking control over it by respective person. In general for a person it starts with very small conversation and leads to intolerable cruel . So this is the main cause of disputes . The remedy for this is to control himself when the level of Adrenaline is reaching a person’s threshold of losing his temper. Controlling himself could be quite tough task during that situation so this AMT (Angst Management Technology) will alarm him “that you are going intolerable”. AMT works on sensory recognition which can recognize through mainly 5 sensors . They are Facial Image Processing, Pulse rate, Heartbeat, Spinal senses, Voice. These sensors will have lower limit and threshold limit which differs with each person according to their anxiety levels. These sensors help to stimulate the microprocessor and software which will record the AV (Audio – Video) of ongoing conversation, identify the person threshold limit to alarm him and also sending location. This can be used to forensics and in reduction of crime rate is possible, can be used in Medical field for B.P patient, stress management, and Health analysis. Moto of this technology is to say stress is main cause of miseries and that can be controlled by technology. Index Terms – stress management, adrenaline, anger, control, stress management, sensor, tracking, alerting, HTL, LTL. Zig-bee, Vedio Transmission ________________________________________________________________________________________________________
Conkling's Roadrunner: A Subspecies of the California Roadrunner?

-A fossil roadrunner from interstadial deposits (ca. 33,590 BP) in New Mexico is identified as Geococcyx californianus. Fossil remains from California, dating from the subsequent late Wisconsinan stadial, have been assigned to the same taxon. However, approximately contemporaneous populations of larger-sized individuals occurring inland have been named G. conklingi. This taxon also has been recognized as surviving into the early Holocene before becoming extinct. This geographic and temporal pattern is hypothesized as being the result of local adaptations for temperature regulation: hot summer temperatures result in heat stress, resulting in selection against large individuals that otherwise would be best adapted for winter cold; absence of hot temperatures allows selection for large-sized individuals. The inland population of large-sized roadrunners, then, was a geographic and temporal subspecies, G. californianus conklingi. Conkling's Roadrunner (Geococcyx conklingi) was described by Howard (1931) from late Pleistocene deposits of Conkling Cavern, Dona Ana Co., New Mexico (Fig. 1). The species was characterized by size greater than that of the living roadrunner, Geococcyx californianus. Specimens from a nearby site (Shelter Cave) also were referred to this species (G. californianus also was reported, but some specimens definitely were modern and the remainder probably so). Since that time, G. conklingi has been reported from the late Pleistocene sites of San Josecito Cave, in southern Nuevo Leon, Mexico (L. Miller, 1943); and Dark Canyon Cave (Howard, 1971), southwest of Carlsbad, Eddy Co., New Mexico. Gehlbach and Holman (1974) reported its presence in Holocene deposits (<6,000 BP) of Pratt Cave in the Guadalupe Mountains of Culberson Co., Texas; Rea (1980) confirmed the identification, "though it is slightly larger and somewhat different in characters from the type. " Fossil G. californianus have been reported only from the late Pleistocene asphalt deposits of California: Rancho La Brea, Los Angeles Co.; Carpinteria, Santa Barbara Co.; and McKittrick, Kern Co. (Larson, 1930). Thus the literature indicates the presence of G. californianus in California at the same time as G. conklingi occurred inland, with the latter persisting well into the Holocene. In this paper, we add two pertinent records of fossil roadrunners and attempt to clarify the taxonomy and paleoecology of the
Knockout reactions: experimental aspects

The availability of radioactive beams has given rise to intense activity in the field of direct reactions. The removal of one(two)-nucleon (referred to as nucleon knockout in this text) from a fast exotic projectile has been extensively investigated. This lecture provides a general overview of the experimental results achieved using this technique. The sensitivity of the method to different experimental aspects is illustrated with a few examples. Special attention is given to the application of nucleon-knockout reactions as a general purpose spectroscopic tool. Resumé : La disponibilité des faisceaux instables a favorisé le développement d’une activité importante dans le domaine des réactions directes. Pour le cas particulier des faisceaux exotiques de haute énergie, les réactions de cassure de projectiles exotiques (appelées réactions de knockout dans ce texte) ont été très intensivement étudiées Ce cours donne une vision des résultats expérimentaux obtenus en appliquant cette technique. La sensibilité de la méthode aux différents aspects expérimentaux est introduite à partir de la descriptions de quelques cas particulieres. L’utilisation des réactions de knockout en tant qu’outils spectroscopiques est discuté en détail.
Industrial-strength OLTP using main memory and many cores

GaussDB, and its open source version named openGauss, are Huawei's relational database management systems (RDBMS), featuring a primary disk-based storage engine. This paper presents a new storage engine for GaussDB that is optimized for main memory and many cores. We started from a research prototype which exploits the power of the hardware but is not useful for customers. This paper describes the details of turning this prototype to an industrial storage engine, including integration with GaussDB. Standard benchmarks show that the new engine provides more than 2.5x performance improvement to GaussDB for full TPC-C on Intel's x86 many-cores servers, as well as on Huawei TaiShan servers powered by ARM64-based Kunpeng CPUs.
Inequality of Opportunity in Bodyweight among Middle-Aged and Older Chinese: A Distributional Approach

Using the 2011 and 2015 waves of the China Health and Retirement Longitudinal Study (CHARLS) linked with the 2014 CHARLS Life History Survey, we provide a comprehensive analysis on inequality of opportunity (IOp) in both body mass index (BMI) and waist circumference (WC) among middle-aged and older Chinese. We find that IOp ranges from 65.5% to 74.6% for BMI (from 82.1% to 95.5% for WC). Decomposition results show that spatial circumstances such as urban/rural residence and province of residence are dominant. Health status and nutrition conditions in childhood are the second largest contributor. Distributional decompositions further reveal that inequality in bodyweight is not simply a matter of demographic (age and gender) inequalities; our set of spatial and health and nutrition conditions in childhood become much more relevant towards the right tails of the bodyweight distribution, where the clinical risk is focused.
A Mixed Technique to Detect Automated Spam Senders in a Network

: Twitter, a popular micro-blogging service, is traditionally used to share messages and updates with a maximum of 280 characters. It is very open in nature and has a large user base which is often exploited by spammers to commit cybercrimes, like phishing, cyber bullying, harassment and spreading rumors. The proposed approach is to discriminate users depending on their activities with their corresponding followers where the user can bypass the features related to his/her activities, but avoiding those which are based on the followers is challenging. In this paper, a technique to detect automated spammers by combining metadata based features, content based features and interaction based features is proposed. Nine different features are identified for learning the dataset that includes both the legitimate users and spammers. The distinction between the feature categories is analyzed; interaction-based and content-based features are decided to be more effective for the detection of spammers, while metadata-based features are less effective.
Relationship between Age and Tooth Cementum Layers in Norwegian Reindeer

A rapid freeze-sectioning technique for demonstrating annuli in tooth cementurn of rein- deer (Rangifer tarandus) is described. The technique has been applied to a reference material of 37 adult known-age animals and to 1,100 jawbones from two reindeer populations. The known-age ma- terial strongly indicates that the annulation is referable to age. The presence of special rut lines in teeth of males from high quality range indicates that rut-line formation might be related to condition. During a 5-year survey (1963-67) of populations of wild reindeer in mountain areas in southern Norway, some 1,100 lower jawbones from hunted animals were col- lected for age determination. This large sample made it necessary to work out a fairly rapid aging procedure. During the preliminary work several methods were at- tempted. All of these were based on the findings that annuli laid down in tooth den- tine or cementum can be used to determine age in different mammalian species (Laws 1952, 1953, Sergeant and Pimlott 1959, Low and Cowan 1963, McEwan 1963, Linhart and Knowlton 1967, and others). We did not succeed in revealing the an- nuli by grinding, and embedding pro- cedures required too much time. However, annuli can also be demonstrated in decalci- fied frozen sections, as mentioned by Mc- Ewan (1963:112). Although apparently not in use by other authors, freeze-section- ing seemed promising, being both rapid and simple. We accordingly worked out a procedure, details of which will be pre- sented together with a reliability test per- formed on specimens of known age. We noted early that the presence of special rut lines in teeth from males seemed 1 We wish to thank the Norwegian State Game Research Institute and the University of Oslo for financial support, and the State Veterinary Labora- tory for Northern Norway, Harstad, for the supply of known-age material. to be restricted to one of the two popula- tions studied. We feel that a discussion of this observation might also throw some light on the formation of stainable growth layers in teeth. MATERIAL AND METHODS The reference material consisted of lower jawbones from: 1. Eight males and 11 females (domestic) of known age supplied by the State Vet- erinary Laboratory for Northern Norway. 2. Sixteen males and 2 females tagged as calves and killed at different times of the year in Ottadalen wild reindeer area. This area is populated with a small number of animals in very good condition, and the quality of the range is considered excep- tionally good. 3. Thirty males and 19 females killed during the hunting season (Sept. 1-25) in Dovre wild reindeer area and determined from tooth development to be approxi- mately 16 months old. Compared with Ottadalen, the Dovre area is considered overgrazed, owing to previous overpopula- tion. During the survey period the animals here seemed to be in poor condition. The rest of the material consisted of mandibles from 139 males and 22 females from the Ottadalen area, and from 343 males and 511 females from the Dovre area, all killed during the hunting season.