Miracle-dz/UniFAR-FTUs huggingface dataset:
Argatroban use during pediatric interventional cardiac catheterization

Argatroban is a synthetic direct thrombin inhibitor that does not interact with or induce heparin‐dependent antibodies. It is approved for use in adults for prevention and treatment of thrombosis associated with heparin‐induced thrombocytopenia (HIT). It has been administered safely in adults with HIT during coronary interventions. There are no reports of argatroban use for anticoagulation in pediatric patients. The present case describes the use of argatroban during coil embolization of a Fontan fenestration in a child with a history of HIT. The patient received a single bolus dose of 150 μg/kg of argatroban at the onset of the intervention. The fenestration was successfully occluded with a detachable coil. The activated clotting time (ACT) was > 200 sec throughout the procedure. The ACT returned to baseline 72 min after the bolus. No complications occurred. This case demonstrates the safe and successful use of argatroban during a transcatheter intervention in a pediatric patient with a history of HIT. The use of argatroban is promising for anticoagulation in children who require an alternative to heparin. Catheter Cardiovasc Interv 2004;61:147–149. © 2004 Wiley‐Liss, Inc.
Application of a hierarchical control structure in the implementation of a manipulator real-time collision avoidance system

Discusses the use of hierarchical control for advanced robotic manipulators, and specifically the three layer hierarchical control system adopted by ARRL. Particular consideration is given to the tactical layer and the desired functionality within a manipulator control system, and it is shown that these functions lead to the requirement for a real-time trajectory planner embedded within the layer. The implementation of a low-level end-effector collision avoidance control system is described in the light of these considerations. The results, based on a PUMA 562 manipulator arm driven by a multiprocessor controller with ultrasonic sensing, are discussed. <<ETX>>
A Holistic Multimedia System for Gastrointestinal Tract Disease Detection

Analysis of medical videos for detection of abnormalities and diseases requires both high precision and recall, but also real-time processing for live feedback and scalability for massive screening of entire populations. Existing work on this field does not provide the necessary combination of retrieval accuracy and performance. ; AB@In this paper, a multimedia system is presented where the aim is to tackle automatic analysis of videos from the human gastrointestinal (GI) tract. The system includes the whole pipeline from data collection, processing and analysis, to visualization. The system combines filters using machine learning, image recognition and extraction of global and local image features. Furthermore, it is built in a modular way so that it can easily be extended. At the same time, it is developed for efficient processing in order to provide real-time feedback to the doctors. Our experimental evaluation proves that our system has detection and localisation accuracy at least as good as existing systems for polyp detection, it is capable of detecting a wider range of diseases, it can analyze video in real-time, and it has a low resource consumption for scalability.
Energy Management of Microgrid in Grid-Connected and Stand-Alone Modes

There are two operation modes of microgrids: grid-connected mode and stand-alone mode. Normally, a microgrid will be connected to the main grid for the majority of time, i.e., operates in the grid-connected mode. In the stand-alone mode, a microgrid is isolated from the main grid; the highest priority for microgrids is to keep a reliable power supply to customers instead of economic benefits. So, the objectives and energy management strategies are different in two modes. In this paper, a novel double-layer coordinated control approach for microgrid energy management is proposed, which consists of two layers: the schedule layer and the dispatch layer. The schedule layer obtains an economic operation scheme based on forecasting data, while the dispatch layer provides power of controllable units based on real-time data. Errors between the forecasting and real-time data are resolved through coordination control of the two layers by reserving adequate active power in the schedule layer, then allocating that reserve in the dispatch layer to deal with the indeterminacy of uncontrollable units. A typical-structure microgrid is studied as an example, and simulation results are presented to demonstrate the performance of the proposed double-layer coordination control method in both grid-connected mode and stand-alone mode.
Microparticle counts in platelet-rich and platelet-free plasma, effect of centrifugation and sample-processing protocols

This study provides the first estimates of microparticle numbers in platelet-rich plasma (PRP) from normal individuals, closer to in-vivo levels, using higher-resolution flow cytometry. We measured platelet (CD41+) and annexin V+ microparticles in fresh and frozen aliquots of PRP, platelet-poor plasma, platelet-free plasma (PFP), and microparticles isolated by high-speed centrifugation. PRP from healthy individuals contained 730 000/&mgr;l total microparticles based on light-scattering measurements. A median of 27 000/&mgr;l microparticles in PRP were of platelet origin and 120 000/&mgr;l annexin V+, and of these, 24 000/&mgr;l were dual-positive procoagulant platelet microparticles. Double centrifugation of PRP removed 99% of platelets, but also 80% of annexin V+ CD41+, 93% of annexin V+ CD41−, and 58% of annexin V− CD41+ microparticles. Loss of microparticles with centrifugation varied from individual to individual. Microparticle counts after isolation by centrifugation and double washing were not significantly different than counts in the original PFP sample, but lower than in PRP. Freeze-thawing of PFP had no effect on platelet microparticle counts, but slightly increased annexin V+, CD41− counts. Freeze-thawing of isolated washed microparticles resulted in a 30–50% increase in annexin V+ microparticles. PRP contains large numbers of cellular microparticles, including platelet and annexin V+ microparticles, which are lost to varying degrees when PRP is double centrifuged to remove platelets. Microparticles remaining in PFP can be recovered by high-speed centrifugation without loss compared to the original PFP sample. Freeze-thawing has variable effects on microparticle counts depending on the sample preparation used.
Architecture and Implementation of a Scalable Sensor Data Storage and Analysis System Using Cloud Computing and Big Data Technologies

Sensors are becoming ubiquitous. From almost any type of industrial applications to intelligent vehicles, smart city applications, and healthcare applications, we see a steady growth of the usage of various types of sensors. The rate of increase in the amount of data produced by these sensors is much more dramatic since sensors usually continuously produce data. It becomes crucial for these data to be stored for future reference and to be analyzed for finding valuable information, such as fault diagnosis information. In this paper we describe a scalable and distributed architecture for sensor data collection, storage, and analysis. The system uses several open source technologies and runs on a cluster of virtual servers. We use GPS sensors as data source and run machine-learning algorithms for data analysis.
The Ovariectomised Sheep as a Model for Testing Biomaterials and Prosthetic Devices in Osteopenic Bone: A Preliminary Study on Iliac Crest Biopsies

A histomorphometric and ultrastructural evaluation on sheep iliac bone was performed. Six sheep were ovariectomised (OVX Group) and 6 were left intact (Sham-aged, Control Group). An iliac crest biopsy was performed randomly in 6 animals at the beginning of the study, then, in all the animals, after 12 and 24 months. A significant decrease in trabecular bone volume, trabecular thickness (p<0.0005) and cell volume (p<0.005) was observed in OVX animals. A modest decrease in trabecular number and osteoid thickness together with an increase in trabecular separation were observed in OVX animals at 12 and 24 months. The osteoid volume showed a significant difference (p<0.05) between the groups. In OVX animals, at 12 months, Scanning Electron Microscopy revealed an enlargement of the trabecular space and a progressive replacement of bone matrix with adipose tissue. These signs were accentuated at 24 months. In conclusion, OVX sheep showed a loss of trabecular bone starting at 12 months after ovariectomy. The developed osteopenic state may be considered as a useful tool when doing research on biomaterial osteointegration. (Int J Artif Organs 2000; 23: 275–81)
Teoria e a prática de um teste adaptativo informatizado

The main of this work is to introduce the subjects related to Computerized Adaptive Testing, or brea y CAT, for the unidimensional three-parameter logistic model of Item Response Theory. We use bayesian approach to estimate the parameter of interest. We present several item selection algorithms and we perform simulations comparing them. The comparisons are made in terms of the mean square error, bias of the trait estimates, the average time for item selection and the average length of test. Furthermore, we show how to install e use the CAT implementation of this work called built in MIcrosoft Excel VBA using interface with the statistical package R.
Use of Aldosterone Antagonists for Treatment of Uncontrolled Resistant Hypertension

BACKGROUND Multiple studies indicate that primary aldosteronism (PA) is common in patients with resistant hypertension, with an estimated prevalence of approximately 20%. Additional studies suggest that beyond this 20% of patients with classical PA, there is a larger proportion of patients with lesser degrees of hyperaldosteronism which contributes even more broadly to antihypertensive treatment resistance. Given these observations, it is intuitive that use of aldosterone antagonists will provide antihypertensive benefit in patients with resistant hypertension and evidence of aldosterone excess. Intriguingly, however, are clinical findings demonstrating substantive benefit of aldosterone antagonists in patients with resistant hypertension, but without demonstrative evidence of hyperaldosteronism, that is, with seemingly normal or even low aldosterone levels. CONCLUSION Spironolactone is clearly established as the most effective fourth agent for treatment of uncontrolled resistant hypertension. Emerging observations suggest a further role of spironolactone for counteracting the effects of diet high in sodium, particularly in obese, hypertensive patients.
Myosin IIB isoform plays an essential role in the formation of two distinct types of macropinosomes

The function and mechanism of macropinocytosis in cells outside of the immune system remain poorly understood. We used a neuroblastoma cell line, Neuro‐2a, to study macropinocytosis in neuronal cells. We found that phorbol 12‐myristate 13‐acetate (PMA) and insulin‐like growth factor 1 (IGF‐1) induced two distinct types of macropinocytosis in the Neuro‐2a cells. IGF‐1‐induced macropinocytosis occurs mostly around the cell bodies and requires phosphoinositide 3‐kinase (PI3K), while PMA‐induced macropinocytosis occurs predominantly in the neurites and is independent of PI3K activity. Both types of macropinocytosis were inhibited by a specific inhibitor of nonmuscle myosin II, blebbistatin. siRNA knockdown of nonmuscle myosin II isoforms, ‐IIA and ‐IIB, resulted in opposite effects on macropinocytosis induced by PMA or IGF. Myosin IIA knockdown significantly increased, whereas myosin IIB knockdown significantly decreased, macropinocytosis with correlating changes in membrane ruffle formation. © 2009 Wiley‐Liss, Inc.
Environment perception based on LIDAR sensors for real road applications

SUMMARY The recent developments in applications that have been designed to increase road safety require reliable and trustworthy sensors. Keeping this in mind, the most up-to-date research in the field of automotive technologies has shown that LIDARs are a very reliable sensor family. In this paper, a new approach to road obstacle classification is proposed and tested. Two different LIDAR sensors are compared by focusing on their main characteristics with respect to road applications. The viability of these sensors in real applications has been tested, where the results of this analysis are presented.
Herpes simplex virus skin infection in man treated with idoxuridine in dimethyl sulphoxide. Results of double-blind controlled trial.

These inquiries suggest that if treatment to influence bloodpressure is necessary at all after cerebral infarction the measures most likely to do good are those that maintain or raise blood-pressure rather than those that lower it, and the patients who most need treatment are the old people with disproportionately low pressures who suffer from symptoms of postural hypotension. We support the statement that the intensity of the pressure rise for the individual is the important thing, not an arbitrary level used to define hypertension regardless of age, sex, and other factors that influence it (Pickering, 1955), and believe that a more precise study than any at present available should be made of the systemic blood-pressure in the survivors of cerebral infarction, and that the relationship of this pressure to life expectancy after stroke should be reassessed.
Pymanopt: A Python Toolbox for Manifold Optimization using Automatic Differentiation

Manifold optimization is a method for (non-convex) optimization of an objective function, subject to constraints which are smooth, in the sense that the set of points which satisfy the constraints admits the structure of a differentiable manifold. While many optimization problems are of the described form, technicalities of differential geometry and the laborious calculation of derivatives pose a significant barrier for experimenting with manifold optimization techniques. We introduce Pymanopt (available at this https URL), a manifold optimization toolbox implemented in Python that - similarly to the Manopt Matlab toolbox - implements several manifold geometries and optimization algorithms. Moreover, we lower the barriers to users further by using automated differentiation for calculating derivative information, saving users time and saving them from potential calculation and implementation errors.
Risk and Protective Factors Mediating Psychological Symptoms and Ideological Commitment of Adolescents Facing Continuous Terrorism

This study evaluated symptoms, risk, and protective factors of adolescents from six Israeli schools exposed to continuous terrorism. All children in the grades selected at each school (7, 9, and 11) were administered anonymous assessment materials measuring posttraumatic, grief, and dissociative symptoms, as well as traumatic exposure, personal resilience, and family factors. A high number of risk factors increased the likelihood of negative symptoms. Perceived personal resilience served as a protective factor against symptom development, perhaps enforced by ideology. Girls living on the West Bank had less severe posttrauma and were more willing to make personal sacrifices for their country. Proactive interventions aimed at enhancing a child's personal resilience and ability to cope with continuous stress may help protect against later symptomatology following traumatic events. Facing terrorism, political ideology may serve a double edge sword: protecting against symptom development as well as contributing to the toxic cycle of violence.
Metabolic imaging Metabolic imaging with cardiac magnetic resonance spectroscopy

The only non invasive technique for the assessment of cardiac metabolism in patients that does not use radiation is magnetic resonance spectroscopy (MRS). By interrogating signals from phosphorus-31 and hydrogen-1, spectroscopy offers a wealth of metabolic information on the heart muscle. This review focuses on the two areas of greatest potential for MRS: heart failure and ischemic heart disease. MRS has demonstrated deranged cardiac energetics in patients with heart failure, and this is probably a major mechanism contributing to contractile dysfunction. In ischemic heart disease, altered energetics are a highly sensitive indicator of the presence of myocardial ischemia, offering the prospect of a non invasive biochemical stress test for the heart. Although major technical development is required for the future, cardiac MRS holds great potential for clinical application. Heart Metab. 2009;44:17–20.
Linear parameter varying system based modeling of hemodynamic response to profiled hemodialysis

This paper proposes a novel linear parameter varying (LPV) system to model the hemodynamic response of end-stage renal failure patients to profiled hemodialysis (PHD). Ultrafiltration rate (UFR) and dialysate sodium concentration (Na) are imposed as the control inputs and the model computes the relative blood volume (RBV), percentage change in heart rate (ΔDHR(%)) and percentage change in systolic blood pressure (ΔDSBP(%)) during the course of hemodialysis. Model parameters are estimated using least squares approach based on data collected from 12 patients where each patient underwent 4 profile hemodialysis sessions. Parameter identification based on four profiled sessions of the same patient revealed an average mean square error of 0.11 for RBV, 0.24 for ΔDHR and 0.43 for ΔDSBP. The results provided a good model to estimate the individual patient's hemodynamic behavior during hemodialysis. The developed model can play a vital role in designing a robust control system to automatically regulate the UFR and Na while maintaining the hemodynamic variables within stable range.
Software Solution: Against Cold Boot Attack

— DRAM is an important memory of a computer. Microprocessor loads the data requested by the user into DRAM before processing the data. Hence, DRAM contains important information in a computer. Recently, researchers discovered that DRAM is vulnerable to attack that is called Cold boot attack. DRAM contents can be recovered even after the computer has been powered off for several minutes. The information obtained can be often use to break the disk encryption system such as File vault. In this paper, we proposed the methodology which explains the complete process and describe the safeguard methods. We design a system keeping few things in our mind the accessibility for the user and Security. This System is defines as a software solution to the cold boot problem. We also used additional feature to prevent DRAM from the machine replacement. The System is designed as the procedure to secure the encryption key and prevent the machine from attack.
Position control of a bidirectional moving magnet actuator based on contactless hall-effect transducer

In this paper it is studied an open loop command method for controlling the position of a bidirectional moving magnet actuator with elastic magnetic forces (MMAEMF). This type of actuator has, due to its design, an equilibrium position that allows displacement of the actuator's rod in both directions. To energize and drive the actuator it is used a method of adjusting the duty-cycle of a PWM signal and MOSFET transistors. As a feedback non-contact displacement transducer it is used an arrangement of two linear ratiometric Hall sensors and a small permanent magnet disc attached to the mobile actuator's rod that moves between the two fixed sensors. Both input data, acquired from the sensors, and output PWM signal is processed through the pins of an open-source electronics prototyping platform based on Atmel microcontroller. Analog data acquired from the sensor is converted to distance after a calibration method through a lookup table. The setup allows measurements to be taken with 0.1 mm precision of the actuator's rod position and to plot the static characteristic of displacement for a range up to ±5mm.
Mesothelial Toxicity of Peritoneal Dialysis Fluids is Related Primarily to Glucose Degradation Products, Not to Glucose Per Se

♦ Objectives High concentrations of glucose and/or formation of glucose degradation products (GDPs) during heat sterilization of peritoneal dialysis fluids (PDFs) are believed to be key factors in the limited biocompatibility of PDFs. We have previously shown that several identified GDPs can specifically impair human peritoneal mesothelial cell (HPMC) function. In the present study we aimed at differentiating the respective roles of glucose and GDPs in the toxicity of PDF to mesothelial cells. ♦ Methods HPMCs were acutely pre-exposed to or incubated chronically in the presence of pH-neutral PDF sterilized by either heat (H-PDF) or filtration (F-PDF). In addition, HPMCs were treated with commercially available H-PDF manufactured either conventionally, that is, in single-chamber containers, or using novel dual-chamber bags that help to substantially decrease GDP formation. Functional assessment of HPMCs included viability, release of interleukin (IL)-6, and proliferation. ♦ Results Viability and release of IL-6 from HPMCs pretreated with H-PDF (pH 7.3) for 1 to 4 hours were significantly reduced compared to cells exposed to corresponding F-PDF. Incubation in medium mixed (1:1) with H-PDF considerably impaired growth of HPMCs, and over a period of 10 days gradually decreased both the viability of HPMCs and their ability to generate IL-6. These effects were either absent from or significantly less in HPMCs exposed to F-PDF. Similar differences were observed when commercial GDP-containing H-PDFs were compared with newly designed H-PDFs free of GDPs. ♦ Conclusions Impaired viability and function of HPMCs exposed to glucose-containing pH-neutral PDF is related predominantly to the presence of GDP and, to a significantly lesser extent, to the presence of glucose per se. Prevention of GDP formation during auto-claving markedly improves the biocompatibility of H-PDF with HPMCs.
Use of Cross-Linked Enzyme Aggregates (CLEAs) for performing biotransformations

The methodology for the preparation of cross-linked enzyme aggregates (CLEAs) and their application as highly effective, recyclable biocatalysts in a wide variety of transformations is reviewed. The method constitutes a combination of enzyme purification and immobilization into a single operation and allows for the use of relatively crude enzyme preparations. The resulting CLEAs have excellent properties for application in organic synthesis: good thermal stability and tolerance to organic solvents coupled with high retention of activity. Applications include various hydrolytic processes, involving lipases, esterases, amidases, proteases, glycosidases, and phytase, redox reactions with oxidases, peroxidases and dehydrogenases and C-C bond forming reactions mediated by oxynitrilases and aldolases.
SYNTHESIS USING LONG SHORT-TERM MEMORY RECURRENT NEURAL NETWORKS

In statistical parametric speech synthesis (SPSS), a few studies have investigated the Lombard effect, specifically by using hidden Markov model (HMM) -based systems. Recently, artificial neural networks have demonstrated promising results in SPSS, specifically by using long short-term memory recurrent neural networks (LSTMs). The Lombard effect, however, has not been studied in the LSTM-based speech synthesis systems. In this study, we propose three methods for Lombard speech adaptation in LSTM-based speech synthesis. In particular, (1) we augment Lombard specific information with the linguistic features as input, (2) scale the hidden activations using the learning hidden unit contributions (LHUC) method, and (3) fine-tune the LSTMs trained on normal speech with a small Lombard speech data. To investigate the effectiveness of the proposed methods, we carry out experiments using small (10 utterances) and large (500 utterances) Lombard speech data. Experimental results confirm the adaptability of the LSTMs, and similarity tests show that the LSTMs can achieve significantly better adaptation performance than the HMMs in both small and large data conditions.