Miracle-dz/UniFAR-FTUs huggingface dataset:
Comprehensive Analysis of Genomic Alterations in Hepatoid Adenocarcinoma of the Stomach and Identification of Clinically Actionable Alterations

Simple Summary Hepatoid adenocarcinoma of the stomach (HAS) is a subset of gastric cancer (GC) histologically characterized by hepatocellular carcinoma-like foci with or without alpha-fetoprotein secretion, which is easily misdiagnosed. Genomic alterations and potential targets for this population are still largely unknown. Additionally, treatment regimens of HAS are mainly based on GC guidelines, which is not reasonable for diseases with great heterogeneity. The present study comprehensively depicts the genomic features of HAS, and they are significantly different from GC, AFP-producing GC (AFPGC), and liver hepatocellular carcinoma (LIHC). Multiple aggressive behavior-related amplificated or deleted regions in HAS are firstly reported. Moreover, reliable and practicable clinically actionable alterations for HAS are identified, providing evidence for making personalized therapy based on the genomic characteristics of HAS instead of GC. Abstract Hepatoid adenocarcinoma of the stomach (HAS) is a rare malignancy with aggressive biological behavior. This study aimed to compare the genetic landscape of HAS with liver hepatocellular carcinoma (LIHC), gastric cancer (GC), and AFP-producing GC (AFPGC) and identify clinically actionable alterations. Thirty-eight cases of HAS were collected for whole-exome sequencing. Significantly mutated genes were identified. TP53 was the most frequently mutated gene (66%). Hypoxia, TNF-α/NFκB, mitotic spindle assembly, DNA repair, and p53 signaling pathways mutated frequently. Mutagenesis mechanisms in HAS were associated with spontaneous or enzymatic deamination of 5-methylcytosine to thymine and defective homologous recombination-related DNA damage repair. However, LIHC was characteristic of exposure to aflatoxin and aristolochic acid. The copy number variants (CNVs) in HAS was significantly different compared to LIHC, GC, and AFPGC. Aggressive behavior-related CNVs were identified, including local vascular invasion, advanced stages, and adverse prognosis. In 55.26% of HAS patients there existed at least one clinically actionable alteration, including ERBB2, FGFR1, CDK4, EGFR, MET, and MDM2 amplifications and BRCA1/2 mutations. MDM2 amplification with functional TP53 was detected in 5% of HAS patients, which was proved sensitive to MDM2 inhibitors. A total of 10.53% of HAS patients harbored TMB > 10 muts/Mb. These findings improve our understanding of the genomic features of HAS and provide potential therapeutic targets.
Constructing girlhood in Turkey: astrology in the Turkish HeyGirl magazine

ABSTRACT This article examines 144 horoscope forecasts in the Turkish girls’ magazine HeyGirl over the period 2019–20 using critical discourse analysis. It argues that although astrology is seemingly playful and harmless, it works as the “institutionalization of superstition” by encouraging girls to judge, evaluate and classify themselves through their experience by using the idea of a “perfect” future. This study therefore seeks to understand what kinds of tactics and strategies are used by horoscope forecasts in order to work like an ideologically disciplinary instrument. Analysis of the macrostructure of the horoscope forecasts identified four principal linguistic and textual tactics used by HeyGirl’s horoscopes: detect (or invent) a situation; transform the situation into a problem; offer a solution for the invented problem; make a promise. Each horoscope forecast was examined by separating its content into these four tactics. These separations open up the envisaged inter-relations between situation, problem, solution and promise. These envisaged inter-relations are used to show how astrology transforms ideology and discourses into “knowledge,” which comes from the future in order to produce, good, docile girls in the Turkish context.
Utilizing subsonic vibration in cryogenic quenching for heat flux enhancement

ABSTRACT An active method for heat transfer enhancement is proposed and thoroughly characterized for the first time for cryogenic quenching, in which mechanical vibrations are directly induced onto the sample to be quenched, employing a compact modular system composed of a pneumatic plunging device along with a DC motor/eccentric cam mechanism, generating oscillations on three different axes at a wide array of amplitude-frequency combinations. The quenching performance was investigated from both flow-field and thermal standpoints, through numerical simulations of the flow behavior, high-speed imaging of the process, and experimentally generated transient quenching and boiling curves under the influence of the governing parameters, underlining their combined effect on the mechanism of heat transfer augmentation. Under optimal conditions of amplitude and frequency, a remarkable CHF enhancement of 270% was obtained and the quenching time was reduced from 5 seconds to 1.8 seconds compared to the non-vibration case, where the vibration frequency was found to be the primary factor involved in the increase of oscillation-driven pressure drop and subsequent cavitation-induced CHF enhancement. Consequently, we are providing researchers in the field of cryogenics a method that not only provides enhanced performance but also offers flexibility enabling active control of the governing parameters of the system.
SARS-CoV-2 in a Mink Farm in Italy: Case Description, Molecular and Serological Diagnosis by Comparing Different Tests

This study described a SARS-CoV-2 infection in minks on an Italian farm. Surveillance was performed based on clinical examination and a collection of 1879 swabs and 74 sera from dead and live animals. The farm was placed under surveillance for 4.5 months, from the end of July 2020, when a man working on the farm tested positive by RT-PCR, till mid-December 2020 when all the animals were sacrificed. Clinical examination revealed no clinical signs or increased mortality rates attributable to SARS-CoV-2, while diagnostic tests detected only four weak PCR-positive samples, but 100% of sera were positive for SARS-CoV-2 anti-S antibodies. The phylogenetic analysis of two SARS-CoV-2 sequences from two minks and the sequence of the worker showed that they belonged to different clades. It could be therefore assumed that two distinct introductions of the virus occurred on the farm, and that the first introduction probably occurred before the start of the surveillance period. From the data collected, and especially from the detection of specific antibodies through the combination of different tests, it can be postulated that syndromic surveillance combined with genome detection by PCR may not be sufficient to achieve a diagnosis in asymptomatic animals. In particular, the serological approach, especially when using tests directed towards the S protein, may be useful for improving the traceability of virus circulation in similar environments.
Influence of oblique angle variations on the thermo-hydraulic characteristics of the oblique fin heat sink with Al2O3 water nanofluid

Abstract The flow mixing through secondary flow is critical for improving the heat transfer of microchannel heat sinks. This study investigates oblique fin heat sinks (OFHSs) under forced convection conditions with Al2O3-water nanofluid under the Re 100–500. The study is referenced with a straight channel heat sink for benchmarking purposes. Five oblique angle configurations (15°, 25°, 35°, 45°, and 55°) were investigated at the constant fin pitch and constant width ratio (primary width-to-secondary width ratio) of 2:1. The RNG k-ε model has been employed with enhanced thermofluidic effect and wall treatment. The findings revealed that secondary flow generation leads the thermal boundary layer to redevelop at each fin, resulting in continuous fluid flow development. Pressure drop increment has been noticed with oblique angles 15° to 25°, and the variation is almost insignificant among the 35°, 45°, and 55° OFHS. The secondary flow rates were found to have a profound effect in all the cases. The 25° degree shows a higher average convection coefficient among all the OFHSs. Also, the convection coefficient varied in the following order for both water and nanofluid: 15° < 25° > 35° > 45° > 55°. The 25° OFHS enables a more uniform water/nanofluids temperature to build up in the streamwise direction than the 35°, 45°, and 55° OFHS. The thermofluidic analysis suggests that the proposed designs have superior heat convection performance than their flow resistance penalty. Therefore, the 25° OFHS offers a promising option for further parametric research in the future.
A micromechanics model for molecular diffusion in materials with complex pore structure

Molecular diffusion in fully saturated porous materials is strongly influenced by the pore space, which, in general, is characterized by a complex topological structure. Hence, information on macroscopic diffusion properties requires up‐scaling of transport processes within nano‐pores and micro‐pores over several spatial scales. A new model in the framework of continuum micromechanics is proposed for predicting the effective molecular diffusivity in porous materials. Considering a representative volume element, characterizing a porous material without any information about the pore space microstructure complexity, the uniform flux is perturbed by recursively embedding shape information hierarchically in the form of the ESHELBY matrix‐inclusion morphology to obtain the effective diffusivity as a function of the recurrence level and the porosity. The model predicts a threshold value for the porosity, below which no molecular diffusion can occur because of the presence of isolated pore clusters that are not connected and unavailable for transport. The maximum porosity, below which no molecular transport is possible, is predicted as one‐third for spherical inclusions. The model allows for extensions to more complex morphologies of the inclusions. We also identify, that the effects of the micro‐structure on molecular transport are characterized by porosity dependent long‐range and short‐range interactions. The developed framework is extended to incorporate realistic pore size distributions across several spatial scales by means of a distribution function within the hierarchical homogenization scheme. Available experimental results assert the model predictions. Copyright © 2015 John Wiley & Sons, Ltd.
Learning From Reliable Unlabeled Samples for Semi-Supervised SAR ATR

Synthetic aperture radar automatic target recognition (SAR ATR) has been suffering from the insufficient labeled samples as the annotation of SAR data is time-consuming. Thus, adding unlabeled samples into training has attracted the attention of researchers. In this letter, a semi-supervised method based on consistency criterion, domain adaptation (DA), and Top- $k$ loss is proposed to alleviate the need for labeled samples. According to consistency criterion that samples generated by the weak and strong augmentations (WSAs) from the same sample belong to the same category, we use the weak and strong augmented unlabeled samples to predict pseudo labels and train the model, respectively. Then, to overcome the issue caused by the domain discrepancy between labeled and unlabeled samples especially when labeled samples concentrate on a narrow azimuth range, a DA component is designed to reduce their discrepancy. Besides, considering the incorrect pseudo labels will hamper the model training, the Top- $k$ loss is adopted for unlabeled samples to mitigate the negative effects. The experimental results on moving and stationary target acquisition and recognition (MSTAR) dataset demonstrate the superiority of our method in semi-supervised SAR ATR. Specifically, we achieve about a 14.29% improvement in recognition accuracy compared to the state-of-the-art when the labeled samples concentrate on a narrow azimuth range.
Youth Psychiatric Hospitalization in Israel during COVID-19: A Multi-Center Study

Abstract: Background During the COVID-19 pandemic there have been numerous reports of increases in psychiatric morbidity and a deterioration of status among existing patients. There is little information about how this increase has affected youth and rates of adolescent psychiatric hospitalization. Our study was aimed at examining trends in youth psychiatric hospitalization during the first year of the COVID-19 pandemic. Method: We used medical records to compare trends in hospitalization rates from 2019 to 2020, among psychiatric youth wards from five different centers in Israel. Results: The number of patients that were hospitalized in youth psychiatric wards decreased significantly from 2019 (Mean ± SD=52.2 ± 28.6 per month) to 2020 (M ± SD = 40.8 ± 22.0; unstandardized B = −11.4, 95% CI = −14.4 to −8.3, p < 0.0001). There was a significant decrease in the number of patients that were hospitalized due to internalizing disorders from 2019 (M ± SD = 22.3 ± 9.3 per month) to 2020 (M ± SD = 16.8 ± 7.7; B = −5.5, 95% CI = −8.0 to −3.0, p = 0.0002) and a marginally significant increase in the number of restraints per month (2019: M ± SD = 2.8 ± 6.8, 2020: M ± SD = 9.0 ± 14.5; Z = −1.96, Rosenthal’s r = 0.36, p = 0.07). Conclusions: There was a significant decline in psychiatric hospitalizations during the pandemic, specifically among patients suffering from internalizing disorders. The reasons for this decline, and the future impact these changes had on hospitalizations during the pandemic demand further research. Study limitations: This is a retrospective multicenter study from five medical centers in Israel, therefore generalizability of our findings is limited.
Channel-Hopping Sequence and Rendezvous MAC for Cognitive Radio Networks

In cognitive radio networks (CRNs), two secondary users (SUs) need to meet on a channel among multiple channels within a finite time to establish a link, which is called rendezvous. For blind rendezvous, researchers have devised ample well-grounded channel hopping (CH) sequences that guarantee smaller time-to-rendezvous. However, the best part of these works lacks the impact of network factors, particularly channel availability and collision during rendezvous. In this study, a new CH scheme is investigated by jointly considering the medium access control (MAC) protocol for single-hop multi-user CRNs. The analysis of our new variable hopping sequence (V-HS) guarantees rendezvous for the asymmetric channel model within a finite time. Although this mathematical concept guarantees rendezvous between two SUs, opportunities can be overthrown because of the unsuccessful exchange of control packets on that channel. A successful rendezvous also requires the exchange of messages reliably while two users visit the same channel. We propose a MAC protocol, namely ReMAC, that can work with V-HS and CH schemes. This design allows multiple rendezvous opportunities when a certain user visits the channel and modifies the conventional back-off strategy to maintain the channel list. Both simulation and analytical results exhibited improved performance over the previous approaches.
Performance of Male Limousine Crossbreed Cattle by Giving RD Flour at Different Levels

The study aimed to evaluate the production performance of male Limousine Crossbreed cattle with different feed levels with the addition of RD flour. It used nine male Limousine crossbreed cattle, aged <1-3 years, with an average initial weight of 335±29,09kg. The method used is an experimental method using CRD with 3x3: T0= Ad libitum corn straw + concentrate without RD powder, T1= Ad libitum corn straw + concentrate containing 7,5% RD, T2= Ad libitum corn straw + concentrate containing 15% RD flour. The variables measured included Daily gain, Average daily gain, feed conversion ratio, and Income over feed cost. Data were analyzed by ANCOVA. Cattle were fed for eight weeks from (March 26 to June 8, 2021), in the Livestock Group of Kucur Village, Dau District, Malang Regency. The result showed that using feed with the addition of RD at different levels of male Limousine crossbreed cattle had a significant effect on FCR (P>0,05) and on Daily gain, Average daily gain, and IOFC (P<0,01) had a different significant effect. This study concluded that the treatment of T1 feed (7.5% "RD" flour) showed the best results for Daily gain (70,67±5,43 kg), Average daily gain (1.26±0.09 kg), FCR (5.85±0.19),, IOFC Rp. 36586.50.
Effects of Selected Metal Nanoparticles (Ag, ZnO, TiO2) on the Structure and Function of Reproductive Organs

Various studies have shown that the reproductive organs are highly sensitive to toxic elements found in the environment. Due to technological progress, the use of nanoparticles has become more common nowadays. Nanoparticles are used for drug delivery because their dimensions allow them to circulate throughout the body and enter directly into the cell. Antimicrobial properties are increasingly used in the manufacture of medical devices, textiles, food packaging, cosmetics, and other consumer products. Nanoparticles provide several benefits, but aspects related to their effects on living organisms and the environment are not well known. This review summarizes current in vivo, and in vitro animal studies focused on the evaluation of toxicity of selected metal nanoparticles (Ag, ZnO, TiO2) on male and female reproductive health. It can be concluded that higher concentrations of metal nanoparticles in the male reproductive system can cause a decrease in spermatozoa motility, viability and disruption of membrane integrity. Histopathological changes of the testicular epithelium, infiltration of inflammatory cells in the epididymis, and prostatic hyperplasia have been observed. Nanoparticles in the female reproductive system caused their accumulation in the ovaries and uterus. Metal nanoparticles most likely induce polycystic ovary syndrome and follicular atresia, inflammation, apoptosis, and necrosis also occurred.
Influence of Unequal Amplification of Methylated and Non-Methylated Template on Performance of Pyrosequencing

Pyrosequencing is one of the technologies widely used for quantitative methylation assessment. The protocol of pyrosequencing experiment consists of PCR amplification of a locus of interest and subsequent sequencing via synthesis of the amplified PCR product. As the PCR in this protocol utilizes one primer set for the amplification of a template originating from both methylated and non-methylated versions of the analysed locus, the unequal amplification of one of the templates may affect the methylation level assessment by pyrosequencing. We have investigated whether the unequal amplification of one of the templates challenges the quantitative properties of the pyrosequencing technology. Our results show that the sensitivity and dynamic range of pyrosequencing can be significantly affected by unequal amplification of the methylated and non-methylated version of the locus of interest in an assay specific manner. Thus, the assessment of the effect of unequal template amplification on the performances of the specific pyrosequencing assay is necessary before using the assay either in research or especially in diagnostic settings.
Effects of an Intensive 6-Week Rehabilitation Program with the HUBER Platform in the Treatment of Non-Specific Chronic Low Back Pain: A Pilot Study

Non-specific chronic low back pain (NSCLBP) is defined as a complex disorder involving structural, biomechanical, cognitive, psychological, social, and lifestyle factors. Non-pharmacological approaches such as exercise and physical therapy have been proposed in first-line treatments, along with psychological follow-up and pain medication if needed. Our objective was to evaluate the effectiveness of an intensive rehabilitation program with HUBER (a multi-axis motorized platform equipped with force sensors, allowing patients to perform physical exercises in an isometric mode) on the spine flexion-to-extension ratio at 60 and 120°/s, pain, and trunk flexibility in individuals with NSCLBP. Twelve participants underwent a clinical evaluation including isokinetic spine strength and participated in a 6-week rehabilitation program with HUBER 360 Evolution. The main findings of this pilot study show that the flexor/extensor ratios at 60°, the flexibility of the hamstring and quadriceps, and muscular endurance of the trunk, disability, and quality of life were significantly improved at the end of the rehabilitation program (p < 0.05). Low back pain and analgesic medication were also reduced. Exercising with the HUBER Platform seems to be effective in managing NSCLBP but a randomized study with a larger sample size and a control group is necessary.
Research on Uncertainty of Landslide Susceptibility Prediction - Bibliometrics and Knowledge Graph Analysis

Landslide prediction is one of the complicated topics recognized by the global scientific community. The research on landslide susceptibility prediction is vitally important to mitigate and prevent landslide disasters. The instability and complexity of the landslide system can cause uncertainty in the prediction process and results. Although there are many types of models for landslide susceptibility prediction, they still do not have a unified theoretical basis or accuracy test standard. In the past, models were mainly subjectively selected and determined by researchers, but the selection of models based on subjective experience often led to more significant uncertainty in the prediction process and results. To improve the universality of the model and the reliability of the prediction accuracy, it is urgent to systematically summarize and analyze the performance of different models to reduce the impact of uncertain factors on the prediction results. For this purpose, this paper made extensive use of document analysis and data mining tools for the bibliometric and knowledge mapping analysis of 600 documents collected by two data platforms, Web of Science and Scopus, in the past 40 years. This study focused on the uncertainty analysis of four key research subfields (namely disaster-causing factors, prediction units, model space data sets, and prediction models), systematically summarized the difficulties and hotspots in the development of various landslide prediction models, discussed the main problems encountered in these four subfields, and put forward some suggestions to provide references for further improving the prediction accuracy of landslide disaster susceptibility.
A prospective study to evaluate the gender prediction of blastocysts by using cell-free DNA within a culture medium

Abstract Background Preimplantation genetic diagnosis (PGD) has been used as an option for couples with the possibility of having a baby with a genetic disorder. The common method for performing this test involves isolating 1 cell from day 3 or a few cells from day 5 embryos and performing genetic studies on the cell-extracted DNA. This method is invasive and can cause abortion after implantation in the uterus. Because of this, 2 noninvasive methods for performing a PGD have been studied: PGD using blastocyst fluid and PGD using embryo culture medium. Objective The aim of this study is to determine the sensitivity of the polymerase chain reaction (PCR) technique to detect the Y chromosome using cell-free DNA within a culture medium for gender prediction of blastocysts. Materials and Methods In this study, the gender of 30 embryos on day 5 was determined using embryonic DNA extraction from the culture medium and the PCR technique to evaluate the sex-determining region Y and fragile X mental retardation genes. Then, the accuracy was assessed using ultrasound. Results The results of the PCR technique showed that 7 embryos were male, but an ultrasound revealed that 13 were male. Conclusion The given results indicated that, because of the low amount of DNA extracted from the culture medium, the diagnosis of the existence of the Y chromosome by this method is still not accurate enough for detecting the gender of the embryo.