Miracle-dz/UniFAR-FTUs huggingface dataset:
Bone mineral density and bone markers in patients with a recent low-energy fracture: effect of 1 y of treatment with calcium and vitamin D 1 3

Background: Low-energy fractures of the hip, forearm, shoulder, and spine are known consequences of osteoporosis. Objective: We evaluated the effect of 1 y of treatment with calcium and vitamin D on bone mineral density (BMD) and bone markers in patients with a recent low-energy fracture. Design: In a double-blinded design, patients with fracture of the hip (lower-extremity fracture, or LEF) or upper extremity (UEF) were randomly assigned to receive 3000 mg calcium carbonate (cid:1) 1400 IU chole-calciferolorplacebo(200IUcholecalciferol). BMDofthehip(HBMD)andlumbarspine(LBMD)wereevaluatedbydual-energyX-rayabsorptiom-etry,andphysicalperformancewasassessedbythetimedUp&Gotest.Serumconcentrationsof25-hydroxycholecalciferol,parathyroidhor-mone(PTH),telepeptideoftypeIcollagen(ICTP),osteocalcin,and N -terminal propeptide of collagen type I were measured. Results: Atotalof122patientswereincluded(84%women; x (cid:1) (cid:2) SD age: 70 (cid:2) 11 y); 68% completed the study. In an intention-to-treat analysis, LBMD increased in the intervention group and decreased in the placebo group, and the difference between the groups was significantafter12mo:0.931 (cid:2) 0.211comparedwith0. 848 (cid:2) 0.194 ( P (cid:3) 0.05). No significant change was shown for HBMD. The effect of treatment was more pronounced in patients aged (cid:3) 70 y. The intervention decreased bone turnover. PTH was significantly lower in the intervention group ( P (cid:3) 0.01) for the LEF patients. ICTP and changeinLBMDweresignificantlyrelatedtophysicalperformance. Conclusions: A 1-y intervention with calcium and vitamin D reduced bone turnover, significantly increased BMD in patients younger than 70 y, and decreased bone loss in older patients. The effect of treatment was related to physical performance. Am J Clin Nutr 2007;86:251–9.
Industrial Structure and Economic Resilience of Non-Metropolitan Regions: An Empirical Base for the Smart Specialization Policies

: In this paper, we aim to describe and explain the regional disparities in economic resilience in Slovakia in the period 1997–2017. We focus on the effects of economic structure in combination with the vertical (potential accessibility) and horizontal geographical location. Since the early 1990s, Slovak (non-)metropolitan regions exhibited deep changes in the sectoral structure of the economy that were followed by sharp unemployment increases. Due to the FDI-fueled economic growth in the last two decades, however, considerable progress in regional economic growth and reduction in unemployment were was recorded. Therefore, Slovak non-metropolitan regions provide valuable lessons for the analysis of regional economic resilience in a long-term period. We ask if, and to what extent were, the prospects of regional renewal after economic crises associated with the geographical location, economic diversity, firm size and sectoral structure of the economy. We employed spatial regression models to test the effects of the potential accessibility, horizontal geographical location and industrial diversity, and sectoral (agriculture, manufacturing) and firm size structure. The dependent variable, Economic Resilience, was measured by the Regional Development Index, combining the indicators of demographic ageing, net migration, income per capita and registered unemployment rate. Potential accessibility and horizontal geographical location were the key predictors of regional economic resilience. Districts with tertiarized and diversified industrial and firm size structures scored, on average, higher in RDI than specialized districts with large firms and/or a high share of agriculture/manufacturing in total employment.
VITAMIN B12 DEFICIENCY AND NOVEL DRUG DELIVERY STRATEGIES

Vitamin B12 (Cobalamin) is a vital micronutrient. Although, it is required in miniscule levels in the body, it performs many vital functions. It is found exclusively in animal sources with a very few plant sources available. Deficiency of Vitamin B12 is a very common cause for megaloblastic anaemia particularly affecting the elderly population and people on vegetarian diet. With very limited plant sources available, fortification of common food with Vitamin B12 supplements in form of Cyanocobalamin becomes the obvious choice for maintaining appropriate levels in vegetarian population to avoid deficiency. However, many challenges are posed when Vitamin B12 is given orally and intramuscularly. Thus, there is a continuous need for development of newer strategies to effectively deliver the appropriate levels of Vitamin B12. There are variety of causes for the deficiency which also includes certain drug induced causes. Many novel drug delivery strategies have been attempted to deliver cobalamin effectively viz. the sublingual route, intranasal route, transdermal route, and these drug delivery strategies have proven to give beneficial results in preclinical trials or in human subjects. This review article gives an overview of the sources, absorption, causes, chemistry, biochemistry, available treatments for deficiency and the recent methods that have evolved for mitigating the problem of Vitamin B12 deficiency.
Peer effect estimation through a covariate-adjusted Regression Discontinuity Design

This thesis uses data on the Austrian labor market to obtain an estimate of a peer effect in parental leave decisions among young fathers. Identiﬁcation arises through a reform of parental leave, when higher beneﬁts led to an increase in the participation rate of 4.7 – 6.6 percentage points. I use the resulting discontinuity around the implementation date of the reform to implement a fuzzy Regression Discontinuity Design (RDD), which allows to obtain estimates of a peer effect of reform-window fathers on their coworkers. I include additional covariates on the observations in order to increase the precision of the estimator and discuss relevant theoretical results on asymptotic inference. The results indicate a quantitatively large increase of the coworker participation rate of 13 – 28 percentage points, however statistical signiﬁcance of the peer effect is weak.
The compact Selaginella genome identifies changes in gene content associated with the evolution of vascular plants

Vascular plants appeared ~410 million years ago then diverged into several lineages of which only two survive: the euphyllophytes (ferns and seed plants) and the lycophytes ( 1 ). We report here the genome sequence of the lycophyte Selaginella moellendorffii (Selaginella), the first non ‐ seed vascular plant genome reported. By comparing gene content in evolutionary diverse taxa, we found that the transition from a gametophyte ‐ to sporophyte ‐ dominated life cycle required far fewer new genes than the transition from a non ‐ seed vascular to a flowering plant, while secondary metabolic genes expanded extensively and in parallel in the lycophyte and angiosperm lineages. Selaginella differs in post ‐ transcriptional gene regulation, including small RNA regulation of repetitive elements, an absence of the tasiRNA pathway and extensive RNA editing of organellar genes.
Coordination of Connected Vehicles on Merging Roads Using Pseudo-Perturbation-Based Broadcast Control

This paper proposes a coordination method for vehicles on merging roads to realize smooth traffic merging. The proposed method can be implemented with a low communication volume in an environment in which the automated/connected vehicles and manually operated vehicles are mixed. The method is based on a pseudo-perturbation-based broadcast controller (PBC), which has the potential to coordinate multiple vehicles with low-cost V2I communication without V2V communication. The PBC indiscriminately broadcasts an identical signal to the vehicles. The volume of such a broadcast communication is less than that of the commonly used unicast communication. This paper overcomes the following three issues to apply the PBC to the traffic merging problem. First, the time-invariant metrics are derived to design a time-invariant objective function corresponding to the traffic merging problem because the PBC is based on the minimization of such a time-invariant function. Second, a (locally) convex objective function to be globally minimized is designed. Finally, the collision avoidance between vehicles is guaranteed. The microscopic traffic simulations demonstrate the effectiveness of the proposed PBC-based coordination method in the presence of uncooperative manually operated vehicles.
UNIVERSITY OF CALIFORNIA RIVERSIDE Inverse Problems on Electrical Networks and in Photoacoustic Tomography A Dissertation submitted in partial satisfaction of the requirements for the degree of Doctor of Philosophy

OF THE DISSERTATION Inverse Problems on Electrical Networks and in Photoacoustic Tomography by Christina Grace Knox Doctor of Philosophy, Graduate Program in Mathematics University of California, Riverside, June 2019 Dr. Amir Moradifam, Chairperson This dissertation investigates two inverse problems, one on electrical networks and another from photo acoustic tomography. First we consider the inverse problem of recovering the conductivities of an electrical network from the knowledge of the magnitude of the current along the edges coupled with either the voltage on the boundary of the network or the current flowing in or out of the network. This problem corresponds to finding the minimizers of a l1 minimization problem. Additionally, we show that while the conductivities are not determined uniquely the flow of the current is uniquely determined. We will also present a convergent numerical algorithm for solving these problems along with basic numerical simulations. Lastly, we will discuss some applications of this inverse problem. Next we consider the inverse problem of determining both the source of a wave and its speed inside a medium from measurements of the solution of the wave equation on the boundary. This problem arises in photoacoustic and thermoacoustic tomography. We will present a brief overview of previous uniqueness results and then present our two original uniqueness results. If the reciprocal of the wave speed squared is harmonic in a simply connected region and
MYB89 regulates accumulation of seed oil

72 In many higher plants, seed oil accumulation is precisely controlled by intricate 73 multi-level regulatory networks, among which transcriptional regulation mainly 74 www.plantphysiol. org on July 9, 2020 Published by Downloaded from Copyright © 2016 American Society of Plant Biologists. All rights reserved. 4 influences oil biosynthesis. In Arabidopsis, the master positive transcription 75 factors, WRINKLED1 (WRI1) and LEAFY COTYLEDON1-LIKE (L1L), are 76 important for seed oil accumulation. We found that an R2R3-MYB transcription 77 factor, MYB89, was predominantly expressed in developing seeds during 78 maturation. Oil and major fatty acid biosynthesis in seeds was significantly 79 promoted by myb89-1 mutation and MYB89 knockdown; MYB89 was thus an 80 important repressor during seed oil accumulation. RNA sequencing revealed 81 remarkable upregulation of numerous genes involved in seed oil accumulation 82 in myb89 seeds at 12 days after pollination. Posttranslational activation of a 83 MYB89glucocorticoid receptor fusion protein and chromatin 84 immunoprecipitation assays demonstrated that MYB89 inhibited seed oil 85 accumulation by directly repressing WRI1 and five key genes and by indirectly 86 suppressing L1L and 11 key genes involved in oil biosynthesis during seed 87 maturation. These results help us to understand the novel function of MYB89 88 and provide new insights into the regulatory network of transcriptional factors 89 controlling seed oil accumulation in Arabidopsis. 90 www.plantphysiol. org on July 9, 2020 Published by Downloaded from Copyright © 2016 American Society of Plant Biologists. All rights reserved.
ATLAS-CONF-2013-007 Search for strongly produced supersymmetric particles in ﬁnal states with two same-sign leptons and jets with the ATLAS detector using 21 fb − 1 of proton–proton collisions at

A search for the production of supersymmetric particles decaying into ﬁnal states with jets, b -jets, missing transverse momentum and two isolated leptons, e or µ , with the same electric charge (same-sign leptons) is presented. The analysis uses a data sample collected during 2012, which corresponds to a total integrated luminosity of 20 . 7 fb − 1 of √ s = 8 TeV proton–proton collisions recorded with the ATLAS detector at the Large Hadron Collider. No deviation from the Standard Model expectation is observed. Exclusion limits are derived for a mSUGRA / CMSSM model, which is compatible with a mass of around 126 GeV for the lightest Higgs boson, and for a wide variety of simpliﬁed models of supersymmetry. The result signiﬁcantly extends previous exclusion limits from several searches for Supersymmetry. A technical problem has been found in the pseudo-experiments used to make Table 4 in the version of March 1. The excluded range in that table is somewhat expanded and the text includes a minor correction. None of the ﬁgures or conclusions have been changed. proton-proton collisions recorded with the ATLAS detector at the Large Hadron Collider. Three signal regions are deﬁned with 0, ≥ 1 and ≥ 3 b -jets, respectively. No deviation from the Standard Model expectation is observed. Therefore the results are presented as model-independent limits and as exclusion limits in a mSUGRA / CMSSM model and in several simpliﬁed models of supersymmetry. The mSUGRA / CMSSM model is compatible with a mass of the lightest Higgs boson around 126 GeV. The diversity of the simpliﬁed models demonstrates the versatility of the analysis. The results put new or signiﬁcantly improved limits in SUSY parameter regions where the lightest squark can be of the 1 st , 2 nd or 3 rd generations, where the mass di ﬀ erences between the supersymmetric particles can be large or compressed, and where R-parity can be conserved or violated. Hence this analysis covers several important aspects of the searches for supersymmetry at the LHC.
Painterly depiction of material properties

Painters are masters of depiction and have learned to evoke a clear perception of materials and material attributes in a natural, three-dimensional setting, with complex lighting conditions. Furthermore, painters are not constrained by reality, meaning that they could paint materials without exactly following the laws of nature, while still evoking the perception of materials. Paintings have to our knowledge not been studied on a big scale from a material perception perspective. In this article, we studied the perception of painted materials and their attributes by using human annotations to ﬁnd instances of 15 materials, such as wood, stone, fabric, etc. Participants made perceptual judgments about 30 unique segments of these materials for 10 material attributes, such as glossiness, roughness, hardness, etc. We found that participants were able to perform this task well while being highly consistent. Participants, however, did not consistently agree with each other, and the measure of consistency depended on the material attribute being perceived. Additionally, we found that material perception appears to function independently of the medium of depiction—the results of our principal component analysis agreed well with ﬁndings in former studies for photographs and computer renderings.
University of Birmingham c+production in pp collisions at s=7 TeV and in p-Pb collisions at sNN=5.02 TeV

: The p T -di(cid:11)erential production cross section of prompt (cid:3) +c charmed baryons was measured with the ALICE detector at the Large Hadron Collider (LHC) in pp collisions at p s = 7 TeV and in p-Pb collisions at p s NN = 5 : 02 TeV at midrapidity. The (cid:3) +c and (cid:3){ c were reconstructed in the hadronic decay modes (cid:3) +c ! pK (cid:0) (cid:25) + , (cid:3) +c ! pK 0S and in the semileptonic channel (cid:3) +c ! e + (cid:23) e (cid:3) (and charge conjugates). The measured values of the (cid:3) +c /D 0 ratio, which is sensitive to the c-quark hadronisation mechanism, and in particular to the production of baryons, are presented and are larger than those measured previously in di(cid:11)erent colliding systems, centre-of-mass energies, rapidity and p T intervals, where the (cid:3) +c production process may di(cid:11)er. The results are compared with the expectations obtained from perturbative Quantum Chromodynamics calculations and Monte Carlo event generators. Neither perturbative QCD calculations nor Monte Carlo models reproduce the data, indicating that the fragmentation of heavy-(cid:13)avour baryons is not well understood. The (cid:12)rst measurement at the LHC of the (cid:3) +c nuclear modi(cid:12)cation factor, R pPb , is also presented. The R pPb is found to be consistent with unity and with that of D mesons within the uncertainties, and consistent with a theoretical calculation that includes cold nuclear matter e(cid:11)ects and a calculation that includes charm quark interactions with a decon(cid:12)ned medium.
Edinburgh Research Explorer Barriers and facilitators to smoking cessation in pregnancy and postpartum: The healthcare professionals’ perspective

Objectives. Health care professionals and the health care environment play a central role in protecting pregnant and post-partum women and their infants from smoking-related harms. This study aimed to better understand the health professional’s perspective on how interactions between women, health care professionals, and the environment inﬂuence how smoking is managed. Design. Semi-structured interviews and focus groups. Methods. Data were from 48 health care staff involved in antenatal or post-partum care at two UK sites, including midwives, obstetricians, health visitors, GPs, pharmacists, service commissioners, and Stop Smoking Service (SSS) advisors and managers. Thematic analysis was guided by a social – ecological framework (SEF). Results. ThemesweredividedacrossthreeSEFlevelsandrepresentedfactorsconnected to the management of smoking in the health care context and the beliefs and behaviour of pregnant or post-partum smokers. Organizational level: Service reconﬁgurations, ‘last resort’nicotinereplacementtherapyprescribingpolicies,andnon-mandatorytrainingwere largely negative factors. There were mixed views on opt-out referral pathways and positive views on carbon monoxide monitoring. Interpersonal level: Protection of client – professional relationships often inhibited frank discussions about smoking, and weak interservice relationships affected SSS referral motivation and quality. Individual level: Professionals felt community midwives had primary responsibility for managing smoking, although midwives felt underskilled
Tissue-Specific Expression and Promoter Analysis of the Tobacco ltpl Gene’

The Nicofiana fabacum lfpl gene (Nflfpl) encodes a small basic protein that belongs to a class of putative lipid transfer proteins. These proteins transfer lipids between membranes in vitro, but their in vivo function remains hotly debated. This gene also serves as an important early marker for epidermis differentiation. We report here, the analysis of the spatial and developmental activity of the Nfltpl promoter, and we define a sequence element required for epidermis-specific expression. Transgenic plants were created containing 1346 bp of the Nflfpl promoter fused upstream of the P-glucuronidase (CUS) gene. In the mature aerial tissues, CUS activity was detected predominantly in the epidermis, whereas in younger aerial tissues, such as the shoot apical meristem and floral meristem, GUS expression was not restricted to the tunica layer. Unexpectedly, CUS activity was also detected in young roots, particularly in the root epidermis. Furthermore, the Nflfpl promoter displayed a tissue and developmental specific pattern of activity during germination. These results suggest that the Nflfpl gene is highly expressed in regions of the plant that are vulnerable to pathogen attack and are thus consistent with the proposed function of lipid transfer proteins in plant defense. Deletions of the promoter from its 5’ end revealed that the 148 bp preceding the translational start site are sufficient for epidermis-specific expression. Sequence comparison identified an eight-nucleotide palindromic sequence CTACCTAC in the leader of Nfltpl, which is conserved in a number of other lfp genes. By gel retardation analysis, the presence of specific DNA-protein complexes in this region was demonstrated. lhe characterization of these factors may lead to the identification of factors that control early events in epidermis differentiation.
Austin Neurosurgery: Open Access Surgical Management of Adult Glioma: A Contemporary Approach

Primary intrinsic brain tumors represent a significant cause of morbidity and mortality in the United States. Advancements in preoperative evaluation, intraoperative cortical and subcortical stimulation mapping, and emerging imaging modalities allow for earlier detection of tumors and more aggressive tumor resections while minimizing neurological morbidity. Interestingly, there is no general consensus in the literature regarding the efficacy of extent of glioma resection for improving patient outcome. Despite the lack of class I substantiation, mounting evidence suggests that more extensive surgical resection for glioma is associated with longer progression-free and overall survival for most patient populations. This evidence must be tempered by the requirement to treat each individual patient based on histological diagnosis and treatment goals.
Personal and Contextual Antecedents of Knowledge Sharing and Innovative Performance among Engineers

Abstract This research investigates the impacts of proactiveness, openness to experience, and extraversion on innovative performance among engineers. The work also examines the mediating role of knowledge sharing. Using a person–situation interaction perspective, the study further explores the moderating role of perceived organizational support (POS) in personality–knowledge sharing relationships. Data collected from engineers (N = 183) across various public and private engineering firms in Pakistan reveal that knowledge sharing mediated the relationship of proactiveness and extraversion with innovative performance. In addition, highly proactive and extraverted engineers are more likely to share knowledge when the POS is high. Contrary to the expectations, engineers who highly exhibit openness to experience are less likely to share knowledge under high POS. These findings provide significant contributions to the theory and practice of engineering management by highlighting the essential link of personality traits with knowledge sharing and innovation among engineers.