Miracle-dz/UniFAR-FTUs huggingface dataset:
IMPACT OF SEA-PORTS CONSTRUCTIONS ON DYNAMICS OF CONNECTED NATURAL SHORES WITHIN UNTIDAL SEAS

Natural conditions of building and exploitation, sea-ports and port constructions are different for tidal and untidal seas. Principal differences are as follows: in the coastal zone of untidal seas, there are no essential tidal sea-level fluctuations including those of large amplitude and there are no reversible tidal currents. Tidal flats and muddy alongshore flows of drifts occur seldom. Differences of tidal characteristics influence the choice of construction and the nature of port configurations. An acute deficiency of drifts in the coastal zone poses the greatest danger for connected shores after the completion of port-related constructions (e.g., jetting, canals, piers). For untidal systems (amplitudes less than 0.5 m), ports can be divided according to environmental conditions into those which are situated: a) in harbours with shallow nearshore water depths, b) in harbours with deep nearshore water depths, c) in lagoons and limans, d) in river estuaries, e) on smoothed deep nearshore bottoms, and f) on smoothed shallow nearshore bottoms. Different combinations of the variants mentioned above are possible. Ports from a, c and f deserve the greatest attention. Ports developed in these environments require numerous and expensive construction and offer the greatest potential impact on connected shores. In this work conditions ofa, c and f types of environments are analyzed. Under such conditions outer portal constructions (piers, jetties, navigable canals, moles, etc.) represent artificial obstacles for sediment drift movement. These structures promote redistribution of drifts in the coastal zone and alter conditions of development of connected natural shores.
One-Pot Tandem Catalytic Epoxidation—CO 2 Insertion of Monounsaturated Methyl Oleate to the Corresponding Cyclic Organic Carbonate

: Conversion of unsaturated fatty acids, FAMEs or triglycerides into the corresponding cyclic organic carbonates involves two reaction steps—double-bond epoxidation and CO 2 insertion into the epoxide—that are generally conducted separately. We describe an assisted-tandem catalytic protocol able to carry out carbonation of unsaturated methyl oleate in one-pot without isolating the epoxide intermediate. Methyl oleate carbonate was obtained in 99% yield and high retention of cis -conﬁguration starting from methyl oleate using hydrogen peroxide and CO 2 as green reagents, in a biphasic system and in the presence of an ammonium tungstate ionic liquid catalyst with KBr as co-catalyst. of tungstate ionic liquid catalysts (TILCs). Path ( a ) regards the synthesis of trioctylmethylammonium tungstate ( 1 ), trioctylmethylphosphonium tungstate ( 2 ) and trioctylmethyl ammonium phosphotungstate ( 3 ); Path ( b ) regards the synthesis of butylmethylimidazolium tungstate ( 4 ).
EXPLORING THE EFFECTS OF SOCIAL INFLUENCE ON USER BEHAVIOR TARGETED TO FEEDBACK SHARING

ABSTRACT The development of networked digital economy keeps opening up new ways for social interactions and interpersonal influences. Drawing upon social sciences theories and the Persuasive Systems Design (PSD) model, this paper explores the effects of social influence design principles on altering user behavior toward engagement in feedback sharing. A theory-driven research framework is composed to underpin the designing of a Twitter-based information system with persuasive social influence features, such as cooperation, competition, recognition, social learning, and social facilitation at its core. Based on a pilot experimental study involving 37 users of the system, the findings indicated several positive effects of the aforementioned persuasive software features. First, cooperation was more salient for active tweeters and users who perceive Twitter as an influential tool. Second, social learning indicated an impact on users with shorter Twitter experience, and together with cooperation, they both demonstrated stronger effects on user behavior when combined with recognition rather than competition. Third, social facilitation presented more significant effects on users who tweet more frequently. Fourth, the results of this pilot study demonstrated considerable persuasive powers of recognition in the design of systems targeted to feedback sharing. This initial pilot study provides valuable input for further research related to social influence on user behavior, and it highlights several useful aspects for designers of persuasive systems.
Quorum sensing effect on the ability of Desulfovibrio vulgaris to form 1 biofilm and to biocorrode carbon steel in saline conditions 2

Sulfate reducing bacteria (SRB) are key contributors to microbial induced corrosion 27 (MIC), which can lead to serious economic and environmental impact. The presence of a 28 biofilm significantly increases the MIC rate. Inhibition of the quorum sensing (QS) 29 system is a promising alternative approach to prevent biofilm formation in various 30 industrial settings, especially considering the significant ecological impact of 31 conventional chemical-based mitigation strategies. In this study, the effect of the QS 32 stimulation and inhibition on Desulfovibrio vulgaris was described in terms of anaerobic 33 respiration, cell activity, biofilm formation and biocorrosion of carbon steel. All these 34 traits were repressed when bacteria were in contact with QS inhibitors, while they were 35 enhanced upon exposure to QS signal molecules as compared to the control. The 36 difference in the treatments was confirmed by transcriptomic analysis performed at 37 different time points after treatments application. Genes related to lactate and pyruvate 38 metabolism, sulfate reduction, electrons transfer and biofilm formation were 39 downregulated upon QS inhibition. On the contrary, QS stimulation led to an 40 upregulation of the above-mentioned genes compared with the control. In summary, these 41 results reveal the impact of QS on the activity of D. vulgaris , paving the way towards the 42 prevention of corrosive SRB biofilm formation via QS inhibition. 43 44 45 46 47 Sulfate reducing bacteria (SRB) are considered key contributors to biocorrosion, 50 particularly in saline environments. Biocorrosion imposes tremendous economic costs, 51 and common approaches to mitigate this problem involve the use of toxic and hazardous 52 chemicals (e.g. chlorine), which raise health and environmental safety concerns. Quorum 53 sensing inhibitors (QSI) can be used as an alternative approach to inhibit biofilm 54 formation and biocorrosion. However, this approach would only be effective if SRB rely 55 on QS for the pathways associated with biocorrosion. These pathways would include 56 biofilm formation, electron transfer, and metabolism. This study demonstrates the role of 57 QS in Desulfovibrio vulgaris on the abovementioned pathways through both phenotypic 58 measurements and transcriptomic approach. The results of this study suggest that QSI can 59 be used to mitigate SRB-induced corrosion problems in ecologically sensitive areas.
A survey on outlier detection methods in data mining

Outliers are data objects whose characteristics differ from the mainstream characteristics of the data objects in a data set. Outlier detection plays a vital role in statistics as well as in data mining. Outlier detection effects to find out hidden and important information from large data sets. It has been a research field with diverse application areas for the past few decades. Outlier detection has been a topic of research in many fields like detecting malicious activity in cyber security, finding fake transactions in banking, detecting abnormality in medical data, identifying defects in industrial products etc. and various methods have been developed for detecting outliers. Most of the methods are developed specifically for certain applications while others are generic methods. Outlier detection methods are grouped into supervised, unsupervised and semi-supervised methods depending on the availability of class labels. Outlier detection methods can also be classified into statistical, proximity-based, clustering-based and classification-based depending on the type of data. We, in this paper, present the relative advantages and limitations of various methods used for detecting outliers.
Effect of Chemical Activation on Coconut Shell Charcoal on the absorption of Laundry Waste

In this study, we want to see the effect of chemical activation on coconut shell charcoal to absorb laundry waste. Chemical activation uses HCL and H2SO4 with concentrations of 10%, 15% and 20% for each activator. The research was conducted by activating coconut shell charcoal in chemistry and physics. Chemical activation is done by soaking the charcoal into HCl and H2SO4 solutions for 24 hours after which physical activation is carried out by oven-burning charcoal at a temperature of 200 oC for 60 minutes. Activated coconut shell charcoal mixed with laundry waste and then stirred using a magnetic stirrer for 60 minutes for the absorption process. After that the laundry waste from the absorption results tested by pH, TDS, Viscosity, clarity and detergent content. The results showed that for all absorption, the best clarity was obtained at a concentration of 20% in HCl and H2SO4 solutions of (37 and 57) Lux. The best impurity particle absorption was indicated by a concentration of 15% with pH values of HCl (7.4) and H2SO4 (6.7), viscosity of HCl (110.93) N / m3 and H2SO4 (116.53) N / m³. While the maximum TDS value is indicated by the concentrations of HCl 10% (321) ppm and H2SO4 in concentration of 15% (309) ppm. While the results for the best detergent content are shown by 15% HCl concentration which is 0.4248 mg / L.
ITH4012, a novel acetylcholinesterase inhibitor with “calcium promotor” and neuroprotective properties

ITH4012 (ethyl 5-amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzol[1,8]naphthyridine-3-carboxylate) is a novel tacrine derivative that can reduce cell death induced by various compounds with different mechanisms of action, such as thapsigargin (reticular stress), H 2 O 2 (free radicals) and veratridine (calcium overload), in bovine chromaffin cell. Cell viability quantified as LDH (lactic dehydrogenase )-release, was significantly reduced by ITH4012 at concentrations ranging from 0.01 µ M to 3 µ M. In the human neuroblastoma cell-line SH-SY5Y, ITH4012 also reduced A β 25-35 (amyloid β 25-35 )-induced apoptosis, determined by flow cytometry. ITH4012 caused a slight elevation in the cytosolic concentration of Ca 2+ ([Ca 2+ ] c ) in fura 2-loaded bovine chromaffin cells, which could be related to the induction of protein synthesis relevant for cell survival. Blockade of protein synthesis by cycloheximide or blockade of Bcl-2´s active site with HA14-1 (ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate) reversed the cytoprotective action of ITH4012. Furthermore, exposure of bovine chromaffin cells for 24 h or 48 h to neuroprotective concentrations of this compound enhanced, nearly 3-fold, the expression of the antiapoptotic protein Bcl-2. In conclusion, ITH4012 is a tacrine derivative that maintains acetylcholinesterase-inhibiting activity (IC 50 =0.8 µ M), but has the additional property of acting as a calcium promotor, a property leading to neuroprotection through the induction of antiapoptotic proteins.
A survey based research to explore the effects of digital transformation on organizations.

Many organizations nowadays feel pressured to change in order to meet customer demands and competitive pressure due to emerging digital technologies. When a combination of digital technologies is used a common heard buzzword is digital transformation. To date there only little academic research with regards to digital transformation and they often provide holistic non-deterministic definitions. In addition literature that dives deeper into the underlying technologies and effects only address specific elements or industries. This gap is address through a literature research and a business model based questionnaire held amongst IT consultants to determine both the concept and expected effects of digital transformation. We speak of digital transformation if a technology induced change by social, mobile, analytics or cloud technologies significantly impacts a minimal of three out of seven dimension on an individual, firm or social level. The research findings show that digital transformation is expected to change organizations across many different fronts as almost all business model constructs have at least one element that is expected to change moderately or even stronger. The greatest impact will be to organizations’ their value proposition, the customer segments they can identify and serve, the way organizations reach their customers, and the resources they use.
Micro strip antenna design for UWB with improved bandwidth

An UWB planar antenna is designed for bandwidth improvement using micro strip radiator. The radiator is designed with epoxy FR- 4 dielectric substrate. The geometry is of rectangular patch with semi round slot at each corner along with a rectangular slot in partial ground plane. The simulation bandwidth is 12.1 GHz and varies from 3.2 GHz to 15.3 GHz. The simulated result shows that the maximum gain achieves 5.4 dB at 14.3 GHz. The radiation characteristics are almost omnidirectional and dipole shape in H- and E- plane respectively. The simulation is carried out with HFSS simulator.
Cells Is Antigen Independent T + Production by Antigen-Specific CD8 Cutting Edge: OFF Cycling of TNF

Although they are known for their capacity to kill infected cells, Ag-speciﬁc CD8 1 T cells elaborate other effector mechanisms, including TNF and IFN- g , that contribute to defense against infection. Ag-speciﬁc CD8 1 T cells rapidly turn ON and turn OFF IFN- g production in direct response to Ag contact, presumably to minimize the potential immunopathology that could result from inappropriate secretion of this inﬂam-matory mediator. In this study, we show, using in vitro propagated and directly ex vivo-analyzed Ag-speciﬁc CD8 1 T cells, that in contrast to Ag-dependent ON/OFF cycling of IFN- g production, the cessation of TNF production by the same IFN- g producing cells is rapid and Ag independent. The Journal of Immunology, 2000, 165: 5387–5391. microbial by two important mechanisms: lysis of infected cells and production of cytokines such as IFN- g and TNF (1). To minimize the damage to the host, these effector mechanisms employed by Ag-speciﬁc CD8 1 T cells have to be strictly regulated. Recently, it was shown that ON/OFF cycling of IFN- g by virus-speciﬁc CD8 1 T cells is rapid and Ag dependent (2, 3). The same virus-speciﬁc CD8 1 T cells produce TNF, and TNF ON cycling is Ag-dependent also. In this study, we address the role of Ag in OFF cycling of TNF in Ag-speciﬁc CD8 1 T cells.
Changing Southern Ocean palaeocirculation and effects on global climate

: Southern Ocean palaeocirculation is clearly related to the formation of a continental ice sheet on Antarctica and the opening of gateways between Antarctica and the Australian and South American continents. Palaeoenvironmental proxy records from Southern Ocean sediment cores suggest ice growth on Antarctica beginning by at least 40 million years (Ma) ago, and the opening of Tasmania–Antarctic and Drake Passages to deep-water flow around 34 and 31 ± 2 Ma, respectively. So, the Eocene/Oligocene transition appears to mark the initiation of the Antarctic Circumpolar Current and thus the onset of thermal isolation of Antarctica with a first major ice volume growth on East Antarctic. There is no evidence for a significant cooling of the deep ocean associated with this rapid (< 350 000 years) continental ice build-up. After a long phase with frequent ice sheets growing and decaying, in the middle Miocene at about 14 Ma, a re-establishment of an ice sheet on East Antarctica and the Pacific margin of West Antarctica was associated with an increased southern bottom water formation, and a slight cooling of the deep ocean, but with no permanent drop in atmospheric p CO 2 . During the late Pleistocene on orbital time scales a temporal correlation between changes in atmospheric p CO 2 and proxy records of deep ocean temperatures, continental ice volume, sea ice extension, and deep-water nutrient contents is documented. I discuss hypotheses that call for a dominant control of glacial to interglacial atmospheric p CO 2 variations by Southern Ocean circulation dynamics. Millennial to centennial climate variability is a global feature, but there is contrasting evidence from various palaeoclimate archives that indicate both interhemispheric synchrony and asynchrony. The role of the Southern Ocean, however, in triggering or modulating climate variability on these time scales only recently received some attention and is not yet adequately investigated.
Structural analysis and optimization of bicycle frame designs

This article analyzes the stress and optimizes the design of a customized bicycle frame using Pro/ENGINEER digital solid modeling computer-aided design software. This study attempts to verify the stress and displacement response of several types of bicycle frames using a wireframe model and then analyze the solid structure. In summary, for a shell-entity frame, the diamond-type frame (diamond-shaped) has the highest rigidity. The mechanical properties of AZ60/Al2O3p magnesium metal matrix nanocomposites by equal channel angular extrusion almost achieve the level of Al6061 aluminum.
Precision Medicine of Sodium Benzoate for the Treatment of Behavioral and Psychological Symptoms of Dementia (BPSD)

Objective: Behavioral and psychological symptoms of dementia (BPSD) are associated with poorer prognosis of dementia. A 24-week study demonstrated that sodium benzoate, a D-amino acid oxidase (DAAO) inhibitor, surpassed placebo in improving cognitive function in early-phase Alzheimer ’ s disease; however, benzoate did not excel placebo in another 6-week study on BPSD. The current study examined whether the precision medicine approach was able to identify speci ﬁ c individuals with BPSD who could bene ﬁ t from benzoate treatment. Methods: In the randomized, double-blind, placebo-controlled, 6-week trial, 97 patients with BPSD were allocated to receive 250 – 1500 mg/day of sodium benzoate or placebo. Cognitive function was measured by the Alzheimer ’ s disease assessment scale-cognitive subscale (ADAS-cog) and behavioral and psychological symptoms were mainly measured by Behavioral Pathology in Alzheimer ’ s Disease Rating Scale (BEHAVE-AD). DAAO level, amino acids (L-serine, D-serine, L-alanine, and D-alanine, glycine), and two antioxidants (catalase, superoxide dismutase) were assayed in peripheral blood. Results: After benzoate treatment, DAAO inhibition was correlated with ADAS-cog decrease (p = 0.034), while baseline DAAO level was correlated with baseline BEHAVE-AD score. Multiple linear regression analyses showed that cognitive improvement after benzoate treatment was correlated with DAAO decrease, female gender, younger age, BMI, baseline BPSD severity, and antipsychotic use. Conclusion: The ﬁ nding suggests that sodium benzoate may have potential to bene ﬁ t cognitive function in a fraction of BPSD patients after 6 weeks of treatment. Of note, the precision medicine approach may be helpful for identifying individuals who could respond to benzoate. More studies are warranted to con ﬁ rm the preliminary ﬁ ndings. Trial Registration: The trial was registered online (https://clinicaltrials.gov/ct2/show/ NCT02103673).
A Protein Kinase Inhibitor Gene Reduces Both Basal and Multihormone-stimulated Prolactin Gene Transcription*

The possible role of the catalytic subunit of the CAMP-dependent protein kinase in mediating the regulation of prolactin gene transcription has been inves- tigated through the use of a synthetic gene encoding the heat-stable inhibitor of the CAMP-dependent pro- tein kinase. To assess the effects of protein kinase inhibitor expression on cAMP induction of prolactin gene transcription, a marker gene containing the rat prolactin promoter and adjacent 5’-flanking sequences linked to the bacterial chloramphenicol acetyltransferase gene was cotransfected with a protein kinase in-hibitor-expression vector. The results demonstrate that the protein kinase inhibitor-expression vector reduced both basal and CAMP-stimulated expression of the cotransfected prolactin-chloramphenicol acetyltransferase gene. A mutant protein kinase inhibitor- expression vector, coding for an inactive inhibitor protein, did not inhibit basal or CAMP-stimulated prolac- tin gene transcription. Furthermore, the protein kinase inhibitor-expression vector did not inhibit zinc induction of the metallothionein promoter. Analysis of protein kinase activity in transfected cells demon- strated that the protein kinase inhibitor expression vector reduced CAMP-dependent protein kinase activ- ity but did not reduce protein kinase C activity. Nuclease protection experiments confirmed that the ef- fects of the inhibitor vector involved changes in correctly initiated transcripts produced from the prolactin promoter. Surprisingly, the protein kinase inhibitor-expression vector reduced the effects of several differ- ent agents including epidermal growth factor, of the the sequence was confirmed by nucleotide sequence analysis. A PKI expression prepared by replacing the HindIII to BglII &globin fragment of RSV-@-globin (12) with the 246-base pair HindIII to BarnHI PKI fragment. The construction of fusion genes containing either 0.6- or 1.9-kilobase pairs of the 5”flanking region, transcription initiation site, and a short portion of the 5”untranslated region of the rat prolactin gene linked to the bacterial chloramphenicol acetyltransferase gene (O.6PRL-CAT and 1.9PRL-CAT, respectively) has In a fusion gene containing prolactin promoter coupled to the a-globin the chloramphenicol acetyltransferase and SV40 sequences of 2.5PRL-CAT (13) with a HinfI to PstI fragment of the human a-globin gene (14) containing a portion of 5”untranslated region, the complete coding sequence plus intervening sequences, and a portion of the 3‘-flanking region. a construct containing mouse metallothionein I promoter as a 0.77-kilobase pair StuI to BglII fragment (15) linked to the chloramphenicol acetyltransferase also prepared.
Virtual training environments for major incident response planning in UK gas infrastructure

Purpose This paper aims to evaluate a virtual training environment for testing UK gas pipeline emergency response plans. Design/methodology/approach Interviews, observations and desk research were used to identify current methods for testing plans. A virtual training environment was developed and evaluated with industry experts by using participatory design techniques. Key themes relating to both the current methods for testing plans and for a virtual training environment were identified using thematic analysis. Findings Improved training performance, remote participation and evidence of decision testing are benefits a virtual training environment can bring to current practice. It is suggested that a virtual training environment can enhance, rather than replace, the current process of testing emergency response plans. Research limitations/implications Analysis of the virtual training environment being used to test plans in a live context would give further ecological validity to the findings. A study of the prototype used to test plans for incidents involving sectors outside the gas industry would further validate the findings. Originality/value The application of a virtual training environment to facilitate testing plans and the decision-making processes for major incidents involving high-pressure gas pipelines and storage sites is yet to be documented. This paper contributes to the literature by documenting the decision-making process and evaluation of a virtual training environment for testing plans in this context.