Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficient simulation of jitter tolerance for all-digital data recovery circuits

Clock and data recovery (CDR) Circuits are being increasingly marketed as intellectual property (IP) blocks for complex system-on-chip (SoC) and network-on-chip (NoC) products. As part of the mixed-signal design flow, an early estimation of system-level performance requires efficient simulation techniques and models to establish design requirements. In this paper we present some of the challenges associated with and efficient methods to estimate the jitter tolerance of an all-digital data recovery circuit. The key insight is that since it is the maximum slope of the phase-modulating sinusoid that causes transient bit errors, an arbitrary waveform with the same maximum slope can be used for a shorter simulation study. We also present known limitations associated with the general usage of this newly proposed method.
An Improved PSO Approach for Profit-based Unit Commitment in Electricity Market

In this paper, we propose a formulation of the unit commitment problem based on the profit under the deregulated electricity market (PBUC). We express the unit commitment problem as a mixed integer nonlinear optimization problem in which the objective is to maximize profits for generation company and the decisions are required to meet all kinds of operating constraints. Under the assumption of competitive market and price forecasting, we developed an improved discrete binary particle swarm optimization (PSO) and standard value PSO to solve this PBUC problem iteratively. A generation company with 10 generating units is used to demonstrate the effectiveness of the proposed approach. Simulation results are compared with those obtained from reference method
A political history of the national sex survey of adults.

"Certainly no aspect of human biology in our current civilization stands more in need of scientific knowledge and courageous humility than that of sex. The history of medicine proves that in so far as man seeks to know himself and face his whole nature, he has become free from bewildered fear, despondent shame, or arrant hypocrisy. As long as sex is dealt with in the current confusion of ignorance and sophistication, denial and indulgence, suppression and stimulation, punishment and exploitation, secrecy and display, it will be associated with a duplicity and indecency that lead neither to intellectual honesty nor human dignity"-Alan Gregg. '
Human step detection from a piezoelectric polymer floor sensor using normalization algorithms

Today, walking trajectory analysis or event detection gained a lot of interest in healthcare environments to prevent pathologies or gait deviations. However, to correctly study the gait of someone is difficult since it generally requires expensive systems that are difficult to implement. In the work presented herein, we propose another approach to retrieve information from a sensor area. As usual gait analysis systems comprise numerous sensors and provide spatial pressure resolution maps of footsteps over a small area; our system gives a signature generated by a single piezoelectric sensor only. The signal delivered by the sensor goes through a normalization calculation process giving a signal which can be compared to a reference signal. A Pearson product-moment correlation coefficient (PPMCC) is determined between the two signals giving a shape similarity indicator. We achieved similarity indicators greater than 95%. It is the first time that this correlation is applied in the field of human step detection.
Steady‐State Pharmacokinetics of Galantamine Are Not Affected by Addition of Memantine in Healthy Subjects

To evaluate the effect of multiple doses of memantine on the pharmacokinetics of galantamine and to assess the safety and tolerability of galantamine with adjunctive memantine treatment, an open‐label, single‐center, drug interaction study was conducted in 16 healthy adults. Subjects received an 8‐mg dose of galantamine extended release once daily during week 1 and a 16‐mg dose of galantamine extended release once daily during week 2. During weeks 3 and 4, they received a 16‐mg dose of galantamine extended release once daily and a 10‐mg dose of memantine twice daily, except on days 1 and 2 of week 3, when memantine was given as 10 mg once daily. The pharmacokinetic profile and parameters of galantamine at steady state were similar after administration of a 16‐mg dose of galantamine once daily alone and after administration with a 10‐mg dose of memantine twice daily. Galantamine 16 mg once daily with adjunctive memantine 10 mg twice daily was well tolerated and safe in healthy subjects.
The merG Gene Product Is Involved in Phenylmercury Resistance in Pseudomonas Strain K-62

ABSTRACT The physiological function of a new gene, hereby designatedmerG, located between merA and merBon the broad-spectrum mer operon of Pseudomonasstrain K-62 plasmid pMR26 was investigated. The 654-bp merGgene encodes a protein with a canonical leader sequence at its N terminus. The processing of the signal peptide of this protein was dose-dependently inhibited by sodium azide, a potent inhibitor of protein export. These results suggest that the mature MerG protein (ca. 20 kDa) may be located in the periplasm. Deletion of themerG gene from the broad-spectrum mer operon of pMR26 had no effect on the inorganic mercury resistance phenotype, but rendered the bacterium more sensitive to phenylmercury than its isogenic wild-type strain. Escherichia coli cells bearing pMU29, which carries a deletion of the merG gene, took up significantly more phenylmercury than the bacteria with the intact plasmid pMRA17. When the merG gene in a compatible plasmid was transformed into the E. coli strain carrying pMU29, the high uptake of and high sensitivity to phenylmercury were almost completely restored to their original levels. These results demonstrate that the merG gene is involved in phenylmercury resistance, presumably by reducing in-cell permeability to phenylmercury.
Effect of Sodium Stearoyl Lactylate on Refinement of Crisp Bread and the Microstructure of Dough

Crisp bread, as a new type of bread, had a stronger hardness, fracturability and a finer texture compared with the tradition hard bread. The objective of this study was to test whether Sodium Stearoyl Lactylate could change the microstructure of dough and improve the texture of crisp bread. Two probes used were P/2 and P/2N and these graphs were calculated by several means. Results of these calculation showed that number of positive peaks of 5-6 sec, as the most appropriate process method, had the minimum coefficient of variation and the maximum correlation with sensory evaluation. After observing the microstructure of dough and testing the texture of crisp bread, it was concluded the addition of SSL promoted a tighter dough structure and improved the quality of bread significantly. The optimal addition dosage was 0.3%.
Aerial Photograph Reseau Mensuration with Sensing Arrays

A method is described for using a solid-state area array in a system to measure automatically the distance between reseau points on aerial photographs. An array is used to detect the center of reseau cross images by determining where the spatial derivative of the image goes to zero. Experimental results from actual aerial imagery show that it is possible to locate the center of typical reseau crosses to a repeatability of 2¿m.
Upregulation of CFTR expression but not SLC 26 A 3 and SLC 9 A 3 in ulcerative colitis

H. LOHI,1* S. MÄKELÄ,1* K. PULKKINEN,1 P. HÖGLUND,5 M. -L. KARJALAINEN-LINDSBERG,2 P. PUOLAKKAINEN,3 AND J. KERE4,6 Departments of 1Medical Genetics, 2Pathology, and 3Surgery, Helsinki University Central Hospital, 4Finnish Genome Center, and 5Hospital for Children and Adolescents, Biomedicum, University of Helsinki, 00014 Helsinki, Finland; and 6Department of Biosciences at Novum, Karolinska Institute, 14157 Huddinge, Sweden
Optimizing data rate for multiple hop wireless body area network

Since the elderly population is increasing all over the world, health care market keeps growing and there is a need for monitoring of health issues. Body Area Network consists of wireless sensors attached on or inside human body for monitoring vital Health related problems, i.e, Electro Cardiogram (ECG), ElectroEncephalogram (EEG), Electronystagmogram(ENG) etc. Data is recorded by each sensor and sent toward coordinator through other sensors meaning multiple hop sensors WBAN system. The multiple hop system is being researched in many fields of wireless system, i.e, ad hod, mobile, ITS and so on. However, in these systems, the relay node just services as forwarding the data even in the multiple sources to multiple receivers system. Whereas, in wireless body area network (WBAN) system, almost the sensors forward the vital data of the other sensors while recording and sending the data of itself to the neighbor one. Therefore, due to the number of packets that is generated at all sensors, the probability of successful transmission and the packet loss are changed. It means that the vital data is lost and the transmit power is wasted. Main aim of this paper is to analyze the successful transmission probability and to optimize the packet rate of all sensors to obtain the highest efficiency in utilization.
Direct Modeling of Image Keypoints Distribution through Copula-based Image Signatures

Local Image Descriptors (LID) aggregation models such as Bag of Words and Fisher Vectors represent an image based on the distribution of its LIDs given a global model, e.g. a visual codebook or a Gaussian Mixture. Inspired by Copula theory, in this paper we propose a LID-based feature that represents directly the behavior of the image LID distribution, without requiring to compute a global model. Following the definition of Copula, we represent the distribution of the image LIDs by describing, on one side, its marginals, and on the other side, a Copula function. The Copula defines the dependencies between the marginals and their mapping to a multivariate probability distribution function. We test the resulting feature for scene recognition and video retrieval (Trecvid data), showing that our approach outperforms, in both tasks, the Bag of Words and the Fisher Vectors Model.
An energy-efficient coarse grained spatial architecture for convolutional neural networks AlexNet

In this paper, we propose a CGSA (Coarse Grained Spatial Architecture) which processes different kinds of convolution with high performance and low energy consumption. The architecture’s 16 coarse grained parallel processing units achieve a peak 152 GOPS running at 500 MHz by exploiting local data reuse of image data, feature map data and filter weights. It achieves 99 frames/s on the convolutional layers of the AlexNet benchmark, consuming 264 mW working at 500MHz and 1V. We evaluated the architecture by comparing some recent CNN’s accelerators. The evaluation result shows that the proposed architecture achieves 3× energy efficiency and 3.5× area efficiency than existing work of the similar architecture and technology proposed by Chen.
Long-Term Locomotor Training Up-Regulates TrkBFL Receptor-like Proteins, Brain-Derived Neurotrophic Factor, and Neurotrophin 4 with Different Topographies of Expression in Oligodendroglia and Neurons in the Spinal Cord

Neurotrophins are potent regulators of neuronal survival, maintenance, and synaptic strength. In particular, brain-derived neurotrophic factor (BDNF), acting through full-length TrkB receptor (TrkB(FL)), is implicated in the stimulation of neurotransmission. Physical activity has been reported to increase BDNF expression in the brain and spinal cord. In this study we have evaluated the hypothesis that activation of a spinal neuronal network, due to exercise, affects the entire spinal neurotrophin system acting via TrkB receptors by modulation of BDNF, neurotrophin 4 (NT-4), and their TrkB receptor proteins. We investigated the effect of treadmill walking (4 weeks, 1 km daily) on distribution patterns and response intensity of these proteins in the lumbar spinal cord of adult rats. Training enhanced immunoreactivity (IR) of both neurotrophins. BDNF IR increased in cell processes of spinal gray matter, mainly in dendrites. NT-4 IR was augmented in the white matter fibers, which were, in part, of astrocytic identity. Training strongly increased both staining intensity and number of TrkB(FL)-like IR small cells of the spinal gray matter. The majority of these small cells were oligodendrocytes, representing both their precursor and their mature forms. In contrast, training did not exert an effect on expression of the truncated form of TrkB receptor in the spinal cord. These results show that both neuronal and nonneuronal cells may be actively recruited to BDNF/NT-4/TrkB(FL) neurotrophin signaling which can be up-regulated by training. Oligodendrocytes of the spinal gray matter were particularly responsive to exercise, pointing to their involvement in activity-driven cross talk between neurons and glia.
Module Clustering to Minimize Delay in Digital Networks

An important aspect of the packaging of digital networks is the allocation of logic gates to modules such that a predetermined objective function is minimized. In order to develop techniques for this partitioning of a logic network we have considered the following problem: Given an acyclic combinational network composed of various primitive blocks such as NOR gates, assume that a maximum of M gates can be "clustered" together into larger modules, and that a maximum of P pins can be accommodated in each larger module. Assume also that in a network composed of such larger modules, no delay is encountered on the interconnections linking two gates internal to a module and a delay of one time unit is encountered on interconnections linking two gates in different modules . Find an easily applied algorithm that will result in a network such that the maximum delay through the network is minimized.
Unfavourable effects of medically indicated oral anticoagulants on survival in idiopathic pulmonary fibrosis

Procoagulant and antifibrinolytic activity has been associated with idiopathic pulmonary fibrosis (IPF); however, investigation of anticoagulant therapy in IPF has suggested deleterious effects. This post hoc analysis evaluated the effect of medically indicated anticoagulation on mortality and other clinical outcomes in IPF. Patients randomised to placebo (n=624) from three controlled trials in IPF were analysed by oral anticoagulant use. End-points included all-cause and IPF-related mortality, disease progression, hospitalisation, and adverse events, over 1 year. At baseline, 32 (5.1%) patients randomised to placebo were prescribed anticoagulants for non-IPF indications, 29 (90.6%) of whom received warfarin. Unadjusted analyses demonstrated significantly higher all-cause and IPF-related mortality at 1 year in baseline anticoagulant users versus nonusers (15.6% versus 6.3%, p=0.039 and 15.6% versus 3.9%, p=0.002, respectively). In multivariate analyses, baseline use of anticoagulants was an independent predictor of IPF-related mortality (hazard ratio 4.7, p=0.034), but not other end-points. Rates of bleeding and cardiac events did not differ significantly between groups. In an exploratory analysis, anticoagulant use at any time during the study was an independent predictor of all end-points. This post hoc analysis suggests that anticoagulants used for non-IPF indications may have unfavourable effects in IPF patients. Future studies are needed to explore this relationship further. Anticoagulant use for medically indicated comorbidities may have unfavourable effects in IPF http://ow.ly/XZC9j
PNH cells are as sensitive to T‐cell‐mediated lysis as their normal counterparts: implications for the pathogenesis of paroxysmal nocturnal haemoglobinuria

The mechanism responsible for the bone marrow failure that is almost invariable in paroxysmal nocturnal haemoglobinuria (PNH) is unknown. Based on the close association between PNH and idiopathic aplastic anaemia, a plausible pathogenetic model predicts that, in PNH, autoreactive T cells specific for haemopoietic stem cells (HSCs) cause depletion of normal HSCs, whereas PNH HSCs escape this T‐cell‐mediated attack. In this study, we addressed the hypothesis that PNH HSCs are resistant to the cytotoxic effect of T cells because they lack surface expression of one or more glycosylphosphatidylinositol (GPI)‐linked molecules. We tested the sensitivity of normal and PNH Epstein–Barr virus (EBV)‐transformed B‐cell lymphoblastoid cell lines (BLCLs) to the cytotoxic effect of autologous EBV‐specific T‐cell lines and clones from a patient with PNH in an in vitro experimental system. We found that the PNH BLCLs were no less sensitive to T‐cell‐mediated cytotoxicity than non‐PNH isogenic BLCLs, indicating that GPI‐linked molecules on the surface of target cells are not required for killing by T cells. This suggests that the mechanism whereby PNH HSCs survive T‐cell attack is not because of the lack of surface expression of one or more GPI‐linked molecules. By implication, other mechanisms become more probable.
ISAR motion parameter estimation using state-space modeling

In this paper, an approach based on state-space modelization and use of an extended Kalman filter (EKF) is applied and evaluated for the problem of focusing distorted inverse synthetic aperture radar (ISAR) images when the target motion is confined to a two-dimensional plane. The use of a multi-sensor array allows the exploitation of spatial information and leads to the consideration of multiple filters with different observation equations. The problem is transformed into parameter estimation of multi-component (MC) polynomial-phase signals (PPS) when impinging on a multi-sensor array. We show through a simulation that the algorithm provides an effective method of achieving accurate motion parameter estimation.
Remote operations for fusion using teleoperation

Purpose – The Joint European Torus (JET) is the flagship for European Fusion Research. This study seeks to address the issue of the need for remote handling in the process of recreating nuclear fusion as a limitless source of clean energy.Design/methodology/approach – Describes in detail the JET remote handling system with its “man in the loop” approach providing the operator with “remote hands” inside the JET Torus.Findings – Finds that the increase in requirement for remote operations has necessitated rationalization of task procedures and their associated paper work.Originality/value – This paper opens the gates for increasing productivity, broadening the scope of remote handling procedures, increasing operating loads and reducing downtime.
Empirical verification of the balanced scorecard

Purpose – The development and empirical verification of the balanced scorecard (BSC) model are key parts of the research of a case study on the performance measurement system (PMS) of the Ydria Motors LL Company (YM). The paper aims to discuss these issues. Design/methodology/approach – The research was performed as a single case study of modelling the BSC for the manufacturing company and founded on complementary use of qualitative and quantitative methods. The central part of the case study is an empirically evaluated layout of the BSC with the Engle-Granger two-step method. Findings – The results and findings from empirical analysis showed that the methods used are appropriate for inclusion in the methodological approach as they are complementary. Therefore, it can be asserted that the introduction of quantitative methods of continuous data analysis for the implementation of the BSC improved the established approach. In this research, an approach that represents the basis for further work in the field .
Netbench: Framework for Evaluation of Packet Processing Algorithms

Many algorithms and hardware architectures are proposed to increase processing speed of time-critical operations in the field of longest prefix matching, packet classification and regular expression matching. Despite this fact, there is still no free and easily extensible platform for evaluation, comparison and experiments with existing approaches. We propose the Net bench Framework which aims to serve as an independent platform for researchers seeking the easiest way to implement their algorithms, as well as the comparison of their algorithms with reference implementations of other approaches. The framework is provided as an open source and can be easily extended to support new algorithms or new comparison methodology. Net bench is publicly available at http://www.fit. vutbr.cz/netbench.
Micronucleus frequency in sheep lymphocytes after in vitro exposure to fungicide tolylfluanid

The fungicide tolylfluanid (N - dichlorofluoromethylthio-N′, N - dimethyl - N - p - tolylsulfamide), was investigated by cytokinesis-block micronucleus assay. Tolylfluanid at the lowest concentration (1 × 10− 6mol L− 1)did not influence significantly the frequency of micronuclei in sheep lymphocyte cultures in comparison with control (32.33 ± 3.51/1000 binucleated cells versus 30.33 ± 2.82/1000 binucleated cells in dimethylsulfoxide (DMSO) control, P = 0.44). Higher tolylfluanid concentrations (1 × 10− 4 and, 1 × 10− 5 mol L− 1) resulted in a significant dose-dependent increase in the number of micronuclei in comparison with control (74.00 ± 13.00/1000 binucleated cells and 52.67 ± 10.12/1000 binucleated cells versus 30.33 ± 2. 82/1000 binucleated cells in DMSO control, P = 0.005 and 0.02, respectively, ANOVA followed by Tukey test P < 0.05). Many of the treated cells also possessed multiple micronuclei. Tolylfluanid did not affect the nuclear division index at all treatment concentrations. Our in vitro results thus demonstrate that tolylfluanid had a significant genotoxic effect at only the highest concentration tested.
Impact of growth factors and PTHrP on early and late chondrogenic differentiation of human mesenchymal stem cells

Common in vitro protocols for chondrogenesis of mesenchymal stem cells (MSCs) induce an inadequate, hypertrophic differentiation cascade reminiscent of endochondral bone formation. We aimed to modify chondrogenic protocols in order to identify potent inducers, promotors, and inhibitors to achieve better chondrogenesis. Nine factors suspected to stimulate or inhibit chondrogenesis were used for chondrogenic in vitro induction of MSC. Differentiation was assessed by immunohistochemistry, alcian‐blue staining, qRT‐PCR, and quantification of alkaline phosphatase (ALP) activity. Pre‐differentiated pellets were transplanted subcutaneously into SCID mice to investigate stable cartilage formation. Transforming growth factor (TGF)‐β was always required for chondrogenic differentiation and deposition of a collagen‐type‐II‐positive extracellular matrix, while bone morphogenetic protein (BMP)‐2, ‐4, ‐6, ‐7, aFGF, and IGF‐I (10 ng/ml) were alone not sufficiently inductive. Each of these factors allowed differentiation in combination with TGF‐β, however, without preventing collagen type X expression. bFGF or parathyroid hormone‐like peptide (PTHrP) inhibited the TGF‐β‐responsive COL2A1 and COL10A1 expression and ALP induction when added from day 0 or 21. In line with a reversible ALP inhibition, in vivo calcification of pellets was not prevented. Late up‐regulation of PTH1R mRNA suggests that early PTHrP effects may be mediated by a receptor‐independent pathway. While TGF‐β was a full inducer, bFGF and PTHrP were potent inhibitors for early and late chondrogenesis, seemed to induce a shift from matrix anabolism to catabolism, but did not selectively suppress COL10A1 expression. Within a developmental window of collagen type II+/collagen type X− cells, bFGF and PTHrP may allow inhibition of further differentiation toward hypertrophy to obtain stable chondrocytes for transplantation purposes. J. Cell. Physiol. 223: 84–93, 2010. © 2009 Wiley‐Liss, Inc.