Miracle-dz/UniFAR-FTUs huggingface dataset:
Nitric oxide, S‐Nitrosation, and endothelial permeability

S‐Nitrosation is rapidly emerging as a regulatory mechanism in vascular biology, with particular importance in the onset of hyperpermeability induced by pro‐inflammatory agents. This review focuses on the role of endothelial nitric oxide synthase (eNOS)‐derived nitric oxide (NO) in regulating S‐Nitrosation of adherens junction proteins. We discuss evidence for translocation of eNOS, via caveolae, to the cytosol and analyze the significance of eNOS location for S‐Nitrosation and onset of endothelial hyperpermeability to macromolecules. © 2013 IUBMB Life, 65(10):819‐826, 2013
Sertraline for the treatment of depression in Alzheimer disease: week-24 outcomes.

BACKGROUND Depression and antidepressant use are common in Alzheimer disease (AD), but the effect of antidepressant treatment for depression on longer term outcomes is unknown. The authors report the Week-24 outcomes of patients who participated in a 12-week efficacy study of sertraline for depression of AD. METHODS One hundred thirty-one participants (sertraline = 67, placebo = 64) with mild-moderate AD and depression participated in the study. Patients who showed improvement on the modified Alzheimer's Disease Cooperative Study Clinical Global Impression-Change (mADCS-CGIC) after 12 weeks of randomized treatment with sertraline or placebo continued double-blinded treatment for an additional 12 weeks. Depression response and remission at 24 weeks were based on mADCS-CGIC score and change in Cornell Scale for Depression in Dementia (CSDD) score. Secondary outcome measures included time to remission, nonmood neuropsychiatric symptoms, global cognition, function, and quality of life. RESULTS One hundred seventeen (89.3%) participants completed all study assessments and 74 (56.5%; sertraline = 38, placebo = 36) completed all 24 weeks on randomized treatment. By 24 weeks, there were no between-group differences in depression response (sertraline = 44.8%, placebo = 35.9%; odds ratio [95% CI] = 1.23 [0.64-2.35]), change in CSDD score (median difference = 0.6 [95% CI: -2.26 to 3.46], chi2 [df = 2] = 1.03), remission rates (sertraline = 32.8%, placebo = 21.8%; odds ratio [95% CI] = 1.61 [0.70-3.68]), or secondary outcomes. Common selective serotonin reuptake inhibitor-associated adverse events, specifically diarrhea, dizziness, and dry mouth, and pulmonary serious adverse events were more frequent in sertraline-randomized patients than in placebo subjects. CONCLUSIONS Sertraline treatment is not associated with delayed improvement between 12 and 24 weeks of treatment and may not be indicated for the treatment of depression of AD.
Rethinking Literate Programming in Statistics

Literate programming is becoming increasingly trendy for data analysis because it allows the generation of dynamic-analysis reports for communicating data analysis and eliminates untraceable human errors in analysis reports. Traditionally, literate programming includes separate processes for compiling the code and preparing the documentation. While this workflow might be satisfactory for software documentation, it is not ideal for writing statistical analysis reports. Instead, these processes should run in parallel. In this article, I introduce the weaver package, which examines this idea by creating a new log system in HTML or LATEX that can be used simultaneously with the Stata log system. The new log system provides many features that the Stata log system lacks; for example, it can render mathematical notations, insert figures, create publication-ready dynamic tables, and style text, and it includes a built-in syntax highlighter. The weaver package also produces dynamic PDF documents by converting the HTML log to PDF or by typesetting the LATEX log and thus provides a real-time preview of the document without recompiling the code. I also discuss potential applications of the weaver package.
Theoretical modelling of fog computing: a green computing paradigm to support IoT applications

In this study, the authors focus on theoretical modelling of the fog computing architecture and compare its performance with the traditional cloud computing model. Existing research works on fog computing have primarily focused on the principles and concepts of fog computing and its significance in the context of internet of things ( IoT ). This work, one of the first attempts in its domain, proposes a mathematical formulation for this new computational paradigm by defining its individual components and presents a comparative study with cloud computing in terms of service latency and energy consumption. From the performance analysis, the work establishes fog computing, in collaboration with the traditional cloud computing platform, as an efficient green computing platform to support the demands of the next generation IoT applications. Results show that for a scenario where 25% of the IoT applications demand real-time, low-latency services, the mean energy expenditure in fog computing is 40.48% less than the conventional cloud computing model.
Semantic Representations of Word Meanings by the Cerebral Hemispheres

Two priming experiments investigated kind and strength of semantic knowledge underlying known, frontier, and unknown low frequency words. Results from Experiment 1 suggest that known words reflect categorical knowledge, but frontier and unknown words reflect thematic knowledge. Thematic knowledge for frontier words appears to be stronger than that for unknown words. Experiment 2 entailed visual half-field presentation of targets. All facilitory effects were restricted to the lvf/RH, and inhibitory effects to the rvf/LH. Experiment 1 findings were mirrored by the RH. Thematic knowledge appears to precede categorical knowledge for the RH, but the opposite may be true of the LH. Results are also discussed in terms of the RH role in meaning acquisition and metacontrol.
Supercritical Fluid Extraction of Metal Chelate: A Review

ABSTRACT Supercritical fluid extraction (SFE), as a new green extraction technology, has been used in extracting various metal species. The solubilities of chelating agents and corresponding metal chelates are the key factors which influence the efficiency of SFE. Other main properties of them such as stability and selectivity are also reviewed. The extraction mechanisms of mainly used chelating agents are explained by typical examples in this paper. This is the important aspect of SFE of metal ions. Moreover, the extraction efficiencies of metal species also depend on other factors such as temperature, pressure, extraction time and matrix effect. The two main complexation methods namely in-situ and on-line chelating SFE are described in detail. As an efficient chelating agent, tributyl phosphate-nitric acid (TBP-HNO3) complex attracts much attention. The SFE of metal ions, lanthanides and actinides as well as organometallic compounds are also summarized. With the proper selection of ligands, high efficient extraction of metal species can be obtained. As an efficient sample analysis method, supercritical fluid chromatography (SFC) is introduced in this paper. Recently, the extraction method combining ionic liquids (ILs) with supercritical fluid has been becoming a novel technology for treating metal ions. The kinetics related to SFE of metal species is discussed with some specific examples.
Floquet analysis of the far-infrared dissociation of a Morse oscillator.

Mise en evidence de deux classes d'etats de quasi-energie: 1) des etats larges qui s'etendent sur un grand domaine de la base de Morse et 2) des etats etroits, localises sur un petit nombre d'etats de Morse. Comparaison a une simulation quantique de la dynamique de dissociation par une methode grille a transformee de Fourier rapide
Optical functions for microwave signals in airborne radar and communication systems

The optical-microwave solutions have become key technologies for space and airborne communication, radar and surveillance systems. The maturity and the performances, in terms of spectral purity and linearity, of optoelectronic components, are such that today they enable optical transmission and processing of broadbandwidth or high-purity microwave signals. Additionally, the use of photonic technologies to assist the analogue-to-digital conversion (ADC) to simplify the RF front-ends.
A NIOS II base wide output range power factor corrector

This paper presents a wide range output voltage interleaved flyback power factor correction circuit, two parallel-connected flyback converter are interleaved, it could provides high efficient and wide range output voltage. The system on programmable chip (SoPC), NIOS II, which is based on field programmable gate array (FPGA) is used to implement the digital controller. To simplify the circuit, discontinuous conduction mode (DCM) PFC structure is choose, in this method, the inductor current feedback could be skipped. So, no circuit is used to get the inductor current, but only an extra analog to digital converter to get the feedback voltage is added to circuit. However, the power factor correction will be approached well. The experiment results show the system have nearly unity power factor, and good dynamic response over a wide output power range.
An 11–18 GHz four-channel DBR multiplexer for electronic warfare systems

This paper deals with the design of a stripline four-channel multiplexer that works in the 11–18 GHz band. It allows the splitting of the input spectrum into four 1-GHz bandwidth channels separated by a 1-GHz band. Good-rejections and -wideband phase management are both ensured by 8th-order Dual Behavior Resonator filters directly interconnected and matched through a single-stub network. To facilitate the overall tuning of this device, new electromagnetic discontinuity models were developed and proved to greatly reduce the EM tuning phase. Finally, a 17.1 cm²-size multiplexer was designed in stripline technology to take profit of its low couplings and high isolation between filters. The performed simulations showed good performances (5 dB in insertion loss and more than 60 dB in wideband rejections).
A simple proof that AND-compression of NP-complete problems is hard

Drucker [1] proved the following result: Unless the unlikely complexity-theoretic collapse coNP NP/poly occurs, there is no AND-compression for SAT. The result has implications for the compressibility and kernelizability of a whole range of NPcomplete parameterized problems. We present a simple proof of this result. An AND-compression is a deterministic polynomial-time algorithm that maps a set of SAT-instances x1,. ,xt to a single SAT-instance y of size poly(maxi|xi|) such that y is satisfiable if and only if all xi are satisfiable. The “AND” in the name stems from the fact that the predicate “y is satisfiable” can be written as the AND of all predicates “xi is satisfiable”. Drucker’s result complements the result by Bodlaender, Downey, Fellows, et al. [2] and Fortnow and Santhanam [3], who proved the analogous statement for OR-compressions, and Drucker’s proof not only subsumes that result but also extends it to randomized compression algorithms that are allowed to have a certain probability of failure. The overall structure of our proof is similar to the arguments of Ko [4] for Pselective sets, which use the fact that tournaments have dominating sets of logarithmic size. We generalize this fact to hypergraph tournaments. For the informationtheoretic part of the proof, we consider a natural generalization of the average noise sensitivity of a Boolean function, which is bounded for compressive maps. We prove this with mechanical calculations that involve the Kullback‐Leibler divergence.
High Prevalence of Clarithromycin Resistance and cagA, vacA, iceA2, and babA2 Genotypes of Helicobacter pylori in Brazilian Children

ABSTRACT We isolated 45 Helicobacter pylori strains from 217 child patients. Resistance to clarithromycin, metronidazole, amoxicillin, and tetracycline was detected in 27%, 13%, 4%, and 0% of strains, respectively. The A2143G mutation was the most prevalent (67%) among clarithromycin-resistant strains. In addition, strain genotyping revealed a significant association between gastritis severity and the simultaneous presence of cagA, vacA s1m1, iceA2, and babA2 genes.
Genetic Diversity and Genetic Heterogeneity of Bigfin Reef Squid “Sepioteuthis lessoniana” Species Complex in Northwestern Pacific Ocean

The bigfin reef squid Sepioteuthis lessoniana Ferussac, 1831 in Lesson (1830–1831) is widely distributed in the Indo-Pacific, where it is a very valuable fishery resource (Dunning, 1998). Thus, a lot of ecological research of this species were reported (e.g. Ikeda, 1933; Choe & Ohshima, 1961; Segawa, 1987; Ueta, 2003; Ikeda et al., 2009). Segawa et al. (1993a; 1993b) showed that within Sepioteuthis lessoninana have diferrences of egg chracteristics and reproductive trait in Ishigakijima Island. Izuka et al. (1994) reported an allozyme analysis found so-called S. lessoniana around Ishigakijima in Okinawa Prefecture, Japan, includes at least three biological species (Figure 1 & 2). Local fishers call the three species “aka-ika,” which has a red body, “shiro-ika” or “aori-ika,” which has a white body, and “kua-ika,” which is smaller than the other two. Of these, the range of “shiro-ika” extends to the coast of the main Japanese islands. This is the extent of its taxonomic classification thus far. This is due in part to the limited number of distinguishing morphological characters but also because the type specimens is no longer available and type locality has not been disignated (Lu et al., 1995; Jereb & Roper, 2006). This makes it difficult to determain whether genetically recognized species are undescraibed species or one of 13 known synonymies (Young, 2002). In this study, we treated “aka-ika” as Sepioteuthis sp. 1, “shiro-ika” as Sepioteuthis sp. 2, and “kua-ika” as Sepioteuthis sp. 3.
The Cytotoxic Properties of Natural Coumarins Isolated from Roots of Ferulago campestris (Apiaceae) and of Synthetic Ester Derivatives of Aegelinol

Grandivittin (1), agasyllin (2), aegelinol benzoate (3) and felamidin (20), four natural coumarins isolated from Ferulago campestris, and several synthetic ester derivatives of aegelinol (4) were tested against four tumor cell lines. Some of them were shown to be marginally cytotoxic against the A549 lung cancer cell line.
Efficacy of Static Stretching and Proprioceptive Neuromuscular Facilitation Stretch on Hamstrings Length After a Single Session

O'Hora, J, Cartwright, A, Wade, CD, Hough, AD, and Shum, GLK. Efficacy of static stretching and proprioceptive neuromuscular facilitation stretch on hamstrings length after a single session. J Strength Cond Res 25(6): 1586-1591, 2011—A number of studies have investigated the efficacy of several repetitions of proprioceptive neuromuscular facilitation stretching (PNF) and static stretching (SS). However, there is limited research comparing the effects of a single bout of these stretching maneuvers. The aim of this study was to compare the effectiveness of a single bout of a therapist-applied 30-second SS vs. a single bout of therapist-applied 6-second hamstring (agonist) contract PNF. Forty-five healthy subjects between the ages of 21 and 35 were randomly allocated to 1 of the 2 stretching groups or a control group, in which no stretching was received. The flexibility of the hamstring was determined by a range of passive knee extension, measured using a universal goniometer, with the subject in the supine position and the hip at 90° flexion, before and after intervention. A significant increase in knee extension was found for both intervention groups after a single stretch (SS group = 7.53°, p < 0.01 and PNF group = 11.80°, p < 0.01). Both interventions resulted in a significantly greater increase in knee extension when compared to the control group (p < 0.01). The PNF group demonstrated significantly greater gains in knee extension compared to the SS group (mean difference 4.27°, p < 0.01). It can be concluded that a therapist applied SS or PNF results in a significant increase in hamstring flexibility. A hamstring (agonist) contract PNF is more effective than an SS in a single stretching session. These findings are important to physiotherapists or trainers working in clinical and sporting environments. Where in the past therapists may have spent time conducting multiple repetitions of a PNF and an SS, a single bout of either technique may be considered just as effective. A key component of the study methodology was the exclusion of a warm-up period before stretching. Therefore, the findings of efficacy of a single PNF are of particular relevance in sporting environments and busy clinical settings where time may be limited.
TESTING THE CONTRIBUTION OF PROSODY TO THE PERCEPTION OF FOREIGN ACCENT

As of yet the contribution of prosodic factors, particularly intonation, to the perception of foreign accent has seldom been the subject of studies in second language acquisition. In perception tests using low-pass filtered stimuli this study shows that a significant number of listeners is able to discriminate American English and German in stretches of speech 30 seconds or longer. The listeners are even more successful in direct pair comparisons, showing that the prosodic characteristics of American English and German are distinct enough to contribute to an obvious language-specific difference. The same tests are repeated using low-pass filtered stimuli with monotonous intonation. In this case all results are significantly worse. It can thus be claimed that intonation is clearly the most important prosodic factor in the perception of foreign accent. The relevance of intonation is also validated in a foreign accent rating task and a direct pair comparison using original foreign-accented American English utterances by native speakers of German and F0-generated and resynthesized versions in which the intonational errors are corrected. Finally, the study also attempts to give an impression of the respective shares of segmental and intonational aspects of foreign accent by comparing the ratings of fully synthesized versions of the speakers’ original utterances (no segmental foreign accent, but intonational foreign accent) and of F0-generated, “improved” versions (no intonational, but segmental foreign accent). It is shown that segmental aspects have a bigger influence on the perception of foreign accent.
Ethyl 2-amino-1-(4-fluorophenyl)-5-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate: crystal structure and Hirshfeld surface analysis

In the title molecule, the central pyrrole ring makes dihedral angles of 9.2 (3) and 67.6 (2)°, respectively, with the ethoxy carbonyl moiety and the fluorophenyl ring. Supramolecular aggregation is due to off-centric π–π stacking interactions involving screw-related pairs of molecules, which are further connected by N—H⋯O and C—H⋯O interactions, forming a sinusoidal pattern
Reporting of outcomes in orthopaedic randomized trials: does blinding of outcome assessors matter?

BACKGROUND Randomization, concealment of treatment allocation, and blinding are all known to limit bias in clinical research. Nonsurgical studies that fail to meet these standards have been reported to inflate the differences between treatment and control groups. While surgical trials can rarely blind surgeons or patients, they can often blind outcome assessors. The aim of this systematic review was threefold: (1) to examine the reporting of outcome measures in orthopaedic trials, (2) to determine the feasibility of blinding in published orthopaedic trials, and (3) to examine the association between the magnitude of treatment differences and the blinding of outcome assessors. METHODS We identified and reviewed thirty-two randomized, controlled trials published in The Journal of Bone and Joint Surgery (American Volume) in 2003 and 2004 for the appropriate use of outcome measures. These trials represented 3.4% of all 938 studies published during that time-period. All thirty-two trials were reviewed by two authors for (1) the outcome measures used and (2) the blinding of outcomes assessors. We calculated the magnitude of the treatment effect of the use of blinded compared with unblinded outcome assessors. RESULTS Ten (31%) of the thirty-two randomized controlled trials used a modified outcome instrument. Of the ten trials, four failed to describe how the outcome instrument was modified. Nine of the ten articles did not describe how the modified instrument was validated and retested. Sixteen of the thirty-two randomized controlled trials did not report blinding of outcome assessors when blinding would have been possible. Among the studies with continuous outcome measure, unblinded outcomes assessment was associated with significantly larger treatment effects than blinded outcomes assessment (standardized mean difference, 0.76 compared with 0.25; p = 0.01). Similarly, in the studies with dichotomous outcomes, unblinded outcomes assessments were associated with significantly greater treatment effects than blinded outcomes assessments (odds ratio, 0.13 compared with 0.42; p < 0.001). The ratio of odds ratios (unblinded to blinded outcomes assessment) was 0.31, suggesting that unblinded outcomes assessment was associated with a potential for exaggeration of the benefit of the effectiveness of a treatment in our cohort of studies. CONCLUSIONS In future orthopaedic randomized controlled trials, emphasis should be placed on detailed reporting of outcome measures to facilitate generalization and the outcome assessors should be blinded, when possible, to limit bias.