Miracle-dz/UniFAR-FTUs huggingface dataset:
HIV_A_323445 877..887

1School of Public Health, CMHS, Wollo University, Dessie, Ethiopia; 2School of Public Health, CMHS, Bahir Dar University, Bahir Dar, Ethiopia; 3Nutrition International (NI) in Ethiopia, Addis Ababa, Ethiopia Background: In Ethiopia, first-line antiretroviral therapy failure is growing rapidly. However, unlike first-line therapy, to date, very little is known about the outcomes of second-line therapy. Thus, this study assessed the rate of viral re-suppression and attrition to care and their predictors among people living with HIV on second-line therapy. Methods: A retrospective cohort study was conducted on 642 people living with HIV at Dessie Comprehensive Specialized Hospital from October 2016 to November 2019. A proportional Cox regression model was computed to explore predictors of viral resuppression (viral load less than 1000 copies/mL) and attrition to care. Results: Out of 642 subjects, 19 (3%), 44 (6.9%), 70 (10.9%), and 509 (79.3%) patients were lost to follow up, died, transferred out, and alive on care, respectively. Similarly, 82.39% (95% CI: 79.24–85.16%) of patients had achieved viral re-suppression, with 96 per 100 person-year rate of re-suppression. Patients who switched timely to second-line therapy were at a higher rate of viral re-suppression than delayed patients [adjusted hazard rate, AHR = 1.43 (95% CI: 1.17–1.74)]. Not having drug substitution history [AHR = 1.25 (95% CI: 1.02–1.52)] was positively associated with viral re-suppression. In contrast, being on anti-TB treatment [AHR = 0.67 (95% CI: 0.49–0.91)] had lower likelihood with viral resuppression. In the current study, attrition to care was 11% (95% CI: 8.7–13.9%). Ambulatory or bedridden patients were more at risk of attrition to care as compared with workable patients [AHR = 2.61 (95% CI: 1.40–4.87)]. Similarly, being not virally resuppressed [AHR = 6.87 (95% CI: 3.86–12.23)] and CD4 count ≤450 cells/mm3 [AHR = 2.61 (95% CI: 1.40–4.87)] were also positively associated with attrition to care. Conclusion: A significant number of patients failed to achieve viral re-suppression and attrition from care. Most identified factors related to patient monitoring. Hence, patientcentered intervention should be strengthened, besides treatment switch.
Impacts of Practice Combinations on Organizational Knowledge: Based on March's Exploration-Exploitation Model

Organizational learning is an important approach for organizations to improve knowledge levels and enhance adaptability to a complex environment. In this paper, based on the exact recreation of March’s classical model on organizational learning, we conduct research systematically on the impacts of different rate combinations of two typical organizational practices, socialization and codification, on the level of organizational knowledge. Environmental dynamism and system openness are taken into account, as contextual variables. The result shows that (1) accelerating codification and slowing down socialization can achieve better outcomes in a stable environment and closed system. (2) Moderate system openness is beneficial for organizational knowledge when in a stable environment. (3) Environmental turbulence has obvious negative effects on organizational knowledge, and the adjustment of rates of socialization and codification only works temporarily, when in the closed system. (4) System openness can relieve the negative correlation between environmental turbulence and organizational knowledge. Furthermore, we discuss some challenges in how to apply research findings in this paper to organizational actual operations and also provide a few suggestions for further studies. Our paper enriches relative literature on March’s agent-based model, and some results and conclusions obtained in the paper can provide a helpful reference for follow-up researches in this domain.
Development of Antioxidant Chitosan Films Incorporated with Quinoa Extract

In this study, the antioxidant chitosan (CH) films were prepared by incorporating quinoa extract (QE) (5, and 10%, wt) into CH film solutions. The effect of QE incorporation into CH film was evaluated by physicomechanical, and active properties (antioxidant, and antimicrobial activity). Active compounds were extracted from QE by distilled water at 60°C during 6 hours. The total phenolic content and 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity of QE were found as 34.35±0.27 mg GAE/100 g (dry weight) and 25.61±1.36 %, respectively. QE included CH films showed higher water vapor permeability values (WVP) and moisture content (p<0.05). The transmittance and L* values of film samples decreased with the increasing QE content whereas opacity and a* values increased (p<0.05). The elastic modulus and tensile strength of CH films did not change significantly by the incorporation of QE, however, the elongation at break values of films increased with the increasing amount of QE. CH films incorporated with QE extract exhibited 15.60±0.68 and 17.92±1.2% of DPPH radical scavenging activity for 5% QE and 10% QE incorporation, respectively. All film samples showed antimicrobial activity against Escherichia coli, and Listeria monocytogenes but QE incorporation did not promote the antimicrobial activity of CH films. CH films with active properties could have a potential to be used as active food packaging films along with conventional packaging films that could reduce the amount of film used.
Endoplura jejuensis sp. nov. and Endoplura koreana sp. nov. (Ralfsiales, Phaeophyceae) from Korea based on molecular and morphological analyses

The crustose brown algal genus Endoplura has been known as a monotypic genus characterized by its intercalary plurangial reproductive structures composed of 2–4 separate parallel filaments terminated by 2–5 sterile cells and by containing several to many chloroplasts per cell. In this study, Endoplura jejuensis sp. nov. and E. koreana sp. nov. from Korea are newly described based on molecular and morphological analyses. Our phylogenetic analyses of the rbcL gene reveal that E. jejuensis sp. nov. and E. koreana sp. nov. are placed in the same clade with “E. aurea” from Japan with a strong bootstrap supporting value. E. jejuensis is characterized by small and light to dark brown crustose thalli of less than 1 cm diameter, tufts of hairs arising from the basal disc, plurangia composed mostly of two separate parallel reproductive filaments terminated by 2–4 sterile cells, and sessile unangia each with a single paraphysis. E. koreana is distinguished by olive or yellowish-brown crustose thalli of up to 3 cm diameter, tufts of hairs arising from the basal disc, and apical parts of erect filaments, plurangia with 2–5 separate reproductive filaments terminated by 2–8 sterile cells, and sessile unangia with 1–2 paraphyses. Our studies also show that “E. aurea” specimens from Japan may be recognized to be a different species from other Endoplura species.
WILLINGNESS-TO-PAY FOR INSULIN IN DIABETES TREATMENT: A SYSTEMATIC REVIEW AND META-ANALYSIS

Background: Insulin treatment is necessary for all patients with type 1 diabetes and a subset of patients with type 2 diabetes. However, lifetime insulin treatment is relatively costly that has put a heavy financial burden on insulin-dependent diabetics. Several studies thus have been conducted widely to estimate diabetes patients' willingness to pay (WTP) for insulin therapies worldwide. This study aimed to derive the diabetes patients' WTP for insulin therapy from the results of previous research studies. Methods: A systematic review and meta-analysis of diabetes patients’ WTP for insulin was conducted. All studies were searched and derived from PubMed combined with MeSH, Cochrane library combined with MeSH, ScienceDirect, and Springer Nature. The WTP values were estimated for three different types of insulin, including short-acting, rapid-acting insulin; long-acting, slow-acting insulin, and mixed insulin. Review Manager 5.1. 4 software was used to conduct the meta-analysis. Results: Twelve studies were identified by the systematic review, in which eight studies were eligible for a meta-analysis. Most studies were conducted in high-income countries (83.3%), mainly in America (41.7%) and Europe (33.3%). The insulin formulation with the highest mean WTP value was Humalog Mix25 insulin, which was recorded at 410.42 USD per month in the UK and more than 120 USD per month in France, Italy, Spain, and Germany; while most of the other insulin formulations had mean WTP values less than 120 USD per month. Compared to diabetes patients, general populations were willing to pay less for insulin, which was observed in the case of Humalog Mix25 insulin (mean 95.77 USD per month vs 205.89 USD per month) and inhaled insulin (mean 50.43 USD per month compared to more than 120 USD per month). The meta-analysis showed the WTP value for insulin was 74.15 USD per month (95% CI; 55.82 - 92.48). Conclusion: This study showed a comparison of WTP values for different insulin formulations worldwide. The mean WTP value for insulin derived from all previous research may provide an initial understanding of the individuals' preference and WTP. This information could contribute to the effort of managing diabetes and reducing the financial burden of this chronic disease.
Hip-preserving reconstruction of the proximal femur with a vascularized fibula autograft and liquid-nitrogen-treated tumor bearing bone

A five-year-old boy with Ewing sarcoma of the proximal femur was operated at our institution with limb-sparing surgery and biological reconstruction of the proximal femur with a vascularized fibular autograft. During this procedure, the proximal femur was soaked in liquid nitrogen which was subsequently fixed to the fibular autograft, while the epiphysis of the femoral head was spared. To the best of our knowledge, this is the first report of epiphysis-sparing surgery of the proximal femur via a vascularized fibular autograft surrounded by a liquid nitrogen-treated tumor bearing bone autograft. Three years postoperatively, the patient remains disease-free, has a full weight-bearing extremity with good function, and a remodeled proximal femur with minimal deformity. There are no radiological or clinical signs indicative of femoral head osteonecrosis. In conclusion, hip-sparing biological reconstruction is a successful method of limb preservation as an alternative to tumor endoprostheses.
Deflection Laws of Gas Drainage Boreholes in Interbedded Soft and Hard Seams: A Case Study at Xinzheng Coal Mine, China

Coal and gas outbursts can lead to serious disasters in coal mines. The drilling of boreholes to predrain the gas is an effective measure for preventing such accidents. However, due to the complexity of the geological situation, the drilling trajectory often deviates from the design trajectory, resulting in poor gas extraction. To solve the problem of gas drainage borehole deflection, an analytic hierarchy process (AHP) model is established based on geological factors, technical factors, and human factors. The AHP model is used to rank the weights of various influencing factors, and the analysis is combined with a drilling model and engineering examples. Finally, the results show that soft and hard interlayers are the most important factors affecting the deflection of the borehole. The rock drilling model is mainly affected by the formation forces. The regularity of the change in the azimuth angle during drilling is not obvious when the angle of the encountered layer is less than some critical value. When the borehole is skewed downward, the deflection angle ranges from 0 to 4°, and the deflection of the borehole occurs mainly at the interface of the rock layers. When the angle of the encountered layer is greater than the critical value, the borehole is skewed upward, with a deflection angle of 0–6°, and the deflection occurs at the rock interface. The trajectory curve obtained by theoretical predictions from field data is found to be consistent with that of an actual project.
CMAR_A_317922 7115..7129

1Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, 101149, People’s Republic of China; 2Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA; 3Key Laboratory of Henan Province for Drug Quality and Evaluation, Ministry of Education of China, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, 450001, People’s Republic of China Objective: The purpose of this study was to identify prognostic inflammatory markers regulated by enhancers in lung adenocarcinoma (LUAD). Methods: Inflammatory indices of 490 LUAD patients in TCGA database were calculated using genomic variation analysis (GSVA). Patients were divided into highand lowinflammatory index groups. Fraction of 22 infiltrating immune cells was estimated using the Cell type Identification By Estimating Relative Subsets Of RNA Transcripts (CIBERSORT). Gene set enrichment analysis (GSEA) was used to analyze gene enrichment. Differentially expressed genes were screened based on TCGA database. The H3K27ac ChIPseq of A549 cells in GEO database (GSE42374) was analyzed to identify super enhancers. Kaplan–Meier method and multivariate Cox proportional hazards models were used for survival analysis. CCK8 and RT-qPCR were used for cellular level verification. Results: Inflammation was associated with better outcome in LUAD patients. Anti-cancer immune cell fractions were upregulated in high-inflammatory index group. Genes enriched in inflammation-related signaling pathways were positively correlated with high-inflammatory index group. A total of 146 upregulated genes regulated by enhancers were screened, of which five genes including GDF10, HPGDS, ABCA8, SLIT3 and ADAMTS8 had significant influence on prognosis. ChIP-seq analysis showed that TGFβ+TNFα treatment promoted the enhancer activation of the five genes. Cellular experiments revealed that there was no significant effect of TGFβ treatment on the five genes expression. TNFα treatment upregulated the five genes expression, while the BET-bromodomain inhibitor JQ1 restored the effect of TNFα. Overexpression of the five genes significantly inhibited the proliferation of A549 and H1299 cells. Conclusion: GDF10, HPGDS, ABCA8, SLIT3 and ADAMTS8 were identified as enhancer-regulated prognostic inflammation-related biomarkers, and the expression of these genes inhibited proliferation of LUAD cells.
Exploring ESL Teachers’ Insights on Corrective Oral Feedback in a Malaysian Secondary Education Context

Feedback is one of the most significant elements in the process of teaching and learning. It serves as a tool to enhance students’ second language proficiency. Thus, the purpose of this study is to investigate how oral feedback is viewed and how it has been maneuvered to assist second language learner’s linguistic competence from the viewpoint of English teachers. Teachers’ perception of feedback is very important because it will determine the amount of feedback used in the process of teaching and learning. This is a qualitative study employing case study research design. It was conducted to 10 English language teachers from secondary schools in Malaysia The instrument used in this study was a semi-structured interview. Data collected from the interview were analyzed using thematic analysis. Several themes have been found during data analysis such as feedback as tool for motivation, oral feedback and learning from mistakes, students’ acceptance of teachers’ oral feedback and feedback as a medium to develop language proficiency. The result indicated that English teachers in Malaysia generally showed positive perception of oral feedback. Furthermore, teachers also reported to have noticed improvement in students’ language competence by listening to teachers’ feedback. Therefore, appropriate measure should be taken to ensure that teachers can provide effective oral feedback during teaching and learning.
RMHP_A_331077 3711..3720

1Department of Epidemiology and Health Statistics, Zhengzhou University, Zhengzhou, People’s Republic of China; 2Department of Science and Laboratory Technology, Dar es Salaam Institute of Technology, Dar es Salaam, Tanzania; 3Edward J. Bloustein School of Planning and Public Policy, Rutgers University, New Brunswick, NJ, USA; 4College of Sanquan, Xinxiang Medical University, Xinxiang, People’s Republic of China; 5Department of Epidemiology and Applied Biostatistics, Kilimanjaro Christian Medical University College, Moshi, Tanzania Objective: The goal of this study was to establish the most efficient boosting method in predicting neonatal low Apgar scores following labor induction intervention and to assess whether resampling strategies would improve the predictive performance of the selected boosting algorithms. Methods: A total of 7716 singleton births delivered from 2000 to 2015 were analyzed. Cesarean deliveries following labor induction, deliveries with abnormal presentation, and deliveries with missing Apgar score or delivery mode information were excluded. We examined the effect of resampling approaches or data preprocessing on predicting low Apgar scores, specifically the synthetic minority oversampling technique (SMOTE), borderline-SMOTE, and the random undersampling (RUS) technique. Sensitivity, specificity, precision, area under receiver operating curve (AUROC), F-score, positive predicted values (PPV), negative predicted values (NPV) and accuracy of the three (3) boosting-based ensemble methods were used to evaluate their discriminative ability. The ensemble learning models tested include adoptive boosting (AdaBoost), gradient boosting (GB) and extreme gradient boosting method (XGBoost). Results: The prevalence of low (<7) Apgar scores was 9.5% (n = 733). The prediction models performed nearly similar in their baseline mode. Following the application of resampling techniques, borderline-SMOTE significantly improved the predictive performance of all the boosting-based ensemble methods under observation in terms of sensitivity, F1-score, AUROC and PPV. Conclusion: Policymakers, healthcare informaticians and neonatologists should consider implementing data preprocessing strategies when predicting a neonatal outcome with imbalanced data to enhance efficiency. The process may be more effective when borderline-SMOTE technique is deployed on the selected ensemble classifiers. However, future research may focus on testing additional resampling techniques, performing feature engineering, variable selection and optimizing further the ensemble learning hyperparameters.
Broadband Dual-Polarized Multidipole Antenna for Base Station Applications

A wideband dual-polarized multidipole antenna for base station applications is proposed. It consists of a pair of large square-shaped loop dipoles and a pair of small rectangle loop dipoles as radiation elements. A pair of small rectangle loop dipoles is fed by T-shaped feed structure which is in the large square-shaped loop dipoles radiating arm so that the antenna generates an additional resonance and obtains a wider bandwidth. The proposed antenna was fabricated and measured, and the results show that the antenna achieves a wide impedance bandwidth of 63.7 % with VSWR<1.5 covering the frequency range from 1.55 to 3 GHz. A high isolation is better than 29 dB within the operating frequency bandwidth. Moreover, an average gain 8 dBi and a stable radiation pattern with 3 dB beamwidth of 69° ± 4° at H-plane are obtained.
Synthesis, characterization and biomedical applications of silver nanoparticles

Introduction and Aim:Silver nanoparticles (AgNPs) have been extensively useful in biomedical applications.This study aims to synthesize silver nanoparticles by lasers ablation and to use them as an anti-bacterial and anti-cancer agent. Materials and Methods:According to the current study, Ag-nanoparticles can be synthesized easily using pulsed laser ablation on a 99.81% pure silver target immersed in deionized water. The prepared nanoparticles werecharacteredbyUV-vis spectroscopy and X-ray diffraction (XRD), transmission electron microscopy (TEM), and atomic force microscopy (AFM) technique.Using a well-diffusion process, the anti-bacterial action of the synthesized Ag nanoparticles was tested versus two Gram-positive bacteria species (S. aureus and S. pyogenes) and two species of Gram-negative bacteria (E. coli and P. aeruginosa). The anticancer activity of the silver nanoparticles was evaluated by the MTT assay. Results:The generated AgNps had a maximum absorbance peak of 400 nm. The XRD analysis verified that the synthesized silver nanoparticles had been nanocrystalline. The AgNPsdid not affect any of the blood parameters. Gram-negative bacteria are more affected by silver than Gram-positive bacteria. The Ag nanoparticles had been shown a maximum anti-bacterial action at a concentration of 80 µg/mland had a lower effect with 20 µg/ml concentration while their efficacy at 40 and 60 µg/ml concentrationsappeared to be variable against all bacterial species.The findings show that AgNPshavea cytotoxic influence on cancer cellsin 80 ? g/ml concentration. Conclusion:In comparison to Gram-positive bacteria, silver nanoparticles show high antibacterial activity against Gram-negative bacteria. The prepared nanoparticles have a potent effect on cancer cells and restricted harmful effects on RBCs.
Antibacterial Effect and Factors Influencing the Relationship between Coffee, Tea Consumption and Dental Caries

Aims: To assess the association between the frequency and quantity of coffee and tea consumption and dental caries severity among adolescents (middle and high schools) in the Eastern Province, Saudi Arabia. Study Design: This is an observational cross-sectional study. Place and Duration of Study: Conducted in the Eastern Province (Dammam and Al-Khobar), Saudi Arabia, from January to February 2019. Methodology: A cross-sectional observational survey study that was carried out in Eastern Province, Saudi Arabia. Validated interview-based questionnaires were used to ask about the background information and the frequency and quantity of coffee and tea consumption with two sections of the survey: The first section was about the demographic data and the second section assessed the frequency and quantity of coffee and tea consumption and examination was done during daylight using disposable dental mirror and blunt probe. Results: A total of 2265 middle school children with a response rate of 77.8%. Out of them, Females accounted for 1288 (56%) and the mean age (±SD) was 14 (±1.322). Regarding parents’ education, 1916 (84.6%) of participants’ fathers and 1836 (81.1%) of their mothers had a high school certificate or higher. There was a significant association between the frequency of coffee and tea consumption and caries (p=0.013). Conclusion: There was a significant association between the frequency of coffee and tea consumption and caries (p=0.013). The frequency of coffee and tea consumption, the higher the caries. However, there was no association between the quantity of coffee and tea consumption and D nor with the overall DMF score.
Thermal and Residual Stress Distributions in Inconel 625 Butt-Welded Plates: Simulation and Experimental Validation

Thermal and residual stress distributions induced by the gas tungsten arc welding (GTAW) process on Inconel 625 were studied using numerical simulation and experiments. A multi-pass welding model was developed that uses a volumetric heat source. Thermomechanical analysis is carried out to assess the Thermal and residual stress distributions. Experiments were carried out with 5 mm thick Inconel 625 plates. X-ray diffraction techniques were used to measure residual stresses, and IR thermometry was employed to capture the temperature values on the welded joints. Simulations were performed with ANSYS numerical code, and a close agreement was found between the predicted and experimentally measured residual stress. Thermal measurements were collected pass by pass from the analysis, and the agreement was 9.08%. The agreement between the measured and analysed residual stress was 11%.