Miracle-dz/UniFAR-FTUs huggingface dataset:
Motion verb sentences activate left posterior middle temporal cortex despite static context

The left posterior middle temporal region, anterior to V5/MT, has been shown to be responsive both to images with implied motion, to simulated motion, and to motion verbs. In this study, we investigated whether sentence context alters the response of the left posterior middle temporal region. ‘Fictive motion’ sentences are sentences in which an inanimate subject noun, semantically incapable of self movement, is coupled with a motion verb, yielding an apparent semantic contradiction (e.g. ‘The path comes into the garden.’). However, this context yields no less activation in the left posterior middle temporal region than sentences in which the motion can be applied to the subject noun. We speculate that the left posterior middle temporal region activity in fictive motion sentences reflects the fact that the hearer applies motion to the depicted scenario by scanning it egocentrically.
Performance comparison of MPPT techniques using Cuk converter for photovoltaic energy conversion system

This paper deals with performance analysis and comparison of photovoltaic (PV) energy conversion system for two different maximum power point tracking (MPPT) techniques. A CUK converter is used in the PV system to implement the MPPT controller. Two different MPPT controllers are designed to locate the maximum power point: Perturb & Observe and Fuzzy logic based. To evaluate and compare the performances of the designed MPPT controllers PV system is operated with different environmental conditions.
Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor

We describe the cloning of a human gene, named ChemR1, encoding a new putative chemokine receptor sharing 48% identity with CC‐chemokine receptor (CCR)4 and 44% identity with CCR1. It displays four extracellular cysteines that are conserved among all other chemokine receptors. ChemR1 transcripts were detected by Northern blotting in the T lymphoblastic cell lines Jurkat and MOLT‐4, but not in the pre‐B lymphoblastic cell line JM‐1. ChemR1 receptor transcripts were also detected by reverse transcription and polymerase chain reaction analysis in unstimulated CD4+ and CD8+ T cells and polymorphonuclear cells prepared from peripheral blood. The chromosomal localization was performed by radiation hybrid mapping and testing of a panel of yeast artificial chromosome clones. This allowed the assignment of the ChemR1 receptor gene to the p21.3‐24 region of human chromosome 3, in close proximity with the functionally characterized CCR. Future work is required to identify the ligand(s) of this new chemokine receptor and to define its role in the recruitment of white blood cell populations.
Embodied knowledge extraction from human motion using singular value decomposition

Embodied knowledge is the knowledge remembered by the human body and reflected by the dexterity in the motion of the body. In this paper, we propose a new method using singular value decomposition for extracting embodied knowledge from the time-series data of the motion which is measured with various sensors such as an accelerometer, a motion capture system and a force sensor. We compose a matrix from the the time-series data and use the left singular vectors of the matrix as the patterns of the motion and the singular values as a scalar, by which each corresponding left singular vector affects the matrix. Two experiments were conducted to testify the method. One is a gesture recognition experiment in which we categorize gesture motions by two kinds of models with the indexes of similarity and estimation using left singular vectors. The other is an ambulation evaluation experiment in which we distinguished the levels of walking disability using a 3D hyperplane constructed by the singular values. Finally we discuss the characteristic and significance of the embodied knowledge extraction using singular value decomposition proposed in this paper.
The first detection of the insertion sequence ISW1 in the intracellular reproductive parasite Wolbachia.

Wolbachia are maternally inherited intracellular rickettsia-like bacteria known to infect a wide range of arthropods. They are associated with a number of different reproductive phenotypes in their hosts, such as cytoplasmic incompatibility, parthenogenesis, and feminization. We report on a novel insertion sequence (IS), ISW1, which was identified in the region downstream of groEL of a Wolbachia strain, wTai. The 573-bp-long ISW1 sequence is the first IS element observed in this organism, displays significant similarity to IS200, and lacks terminal inverted repeats. There were more than 20 copies of ISW1 on the chromosome of wTai. Sequence analysis of nine distinct ISW1 copies and their flanking regions showed that the copies were identical and suggested that ISW1 has no preference for its insertion sites. Possible roles of ISW1 in the adaptation of Wolbachia to intracellular environments and in various reproductive alterations caused by this bacterium are discussed.
Optimization of norovirus virus‐like particle production in Pichia pastoris using a real‐time near‐infrared bioprocess monitor

The production of norovirus virus‐like particles (NoV VLPs) displaying NY‐ESO‐1 cancer testis antigen in Pichia pastoris BG11 Mut+ has been enhanced through feed‐strategy optimization using a near‐infrared bioprocess monitor (RTBio® Bioprocess Monitor, ASL Analytical, Inc.), capable of monitoring and controlling the concentrations of glycerol and methanol in real‐time. The production of NoV VLPs displaying NY‐ESO‐1 in P. pastoris has potential as a novel cancer vaccine platform. Optimization of the growth conditions resulted in an almost two‐fold increase in the expression levels in the fermentation supernatant of P. pastoris as compared to the starting conditions. We investigated the effect of methanol concentration, batch phase time, and batch to induction transition on NoV VLP‐NY‐ESO‐1 production. The optimized process included a glycerol transition phase during the first 2 h of induction and a methanol concentration set point of 4 g L−1 during induction. Utilizing the bioprocess monitor to control the glycerol and methanol concentrations during induction resulted in a maximum NoV VP1‐NY‐ESO‐1 yield of 0.85 g L−1. © 2016 American Institute of Chemical Engineers Biotechnol. Prog. , 32:518–526, 2016
Pharmacokinetics of Adalimumab in Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis

Background:The aim of this meta-analysis was to explore the magnitude of the association between pharmacokinetics of adalimumab and clinical response in patients with inflammatory bowel disease. Methods:A literature search was performed up to December 2013. MEDLINE, EMBASE, Cochrane, and meeting abstracts were reviewed. Studies were included if they analyzed the association of trough levels of adalimumab (TRA) or antibodies against adalimumab (AAA) with clinical response in adult or pediatric inflammatory bowel disease. A Mantel–Haenszel pooled risk estimate provided a measure of the association. Results:Fourteen studies enrolling 1941 patients with inflammatory bowel disease were included in the systematic review. Thirteen studies analyzed clinical outcomes according to TRA. In only 1 study, there was no correlation between high TRA and clinical response. Six of the 7 studies reported a negative correlation between AAA and clinical outcomes. Six studies enrolling 536 patients (Crohn's disease [CD] only) met the meta-analysis inclusion criteria. The pooled odds ratio (OR) for loss of clinical response to adalimumab in patients with CD (N = 4) with positive AAAs was 10.15 (95% confidence interval [CI]: 3.90–26.40, P < 0.0001). Patients with CD with TRA over a predefined cutoff were more likely to be in clinical remission with an OR of 2.6 (95% CI: 1.79–3.77, P < 0.0001). The association was stronger if the analysis was limited to the adult population (N = 3, OR: 7.05, 95% CI: 3.58–13.9, P < 0.0001). Conclusions:The presence of AAA is associated with a higher risk of loss of clinical response to adalimumab, whereas high TRA is associated with greater clinical response rates in CD. More data are needed in ulcerative colitis.
Intrauterine Growth and Neuropsychological Performance in Very Low Birth Weight Preschoolers

Abstract In this study we examined the association between intrauterine growth, indexed either as a categorical variable or continuous dimension, and neuropsychological outcome, in a very low birth weight (VLBW) sample of 143 preschoolers. When the commonly used split at the 10th percentile rank was applied to classify intrauterine growth restriction (IUGR), we found that the growth restricted group (n = 25) exhibited significantly poorer performance in the global motor domain, but not on any other neuropsychological measure. In contrast, when adequacy of intrauterine growth was indexed by standardized birth weight, a continuous dimension, this early risk factor explained a unique portion of the variance in global cognitive abilities and visuospatial skills, as well as in global, fine, and gross motor skills. These findings are consistent with recent magnetic resonance imaging data disclosing global neurodevelopmental changes in the brains of preterm infants with IUGR. When cases classified with IUGR (<10th percentile) were excluded, the relationship between adequacy of intrauterine growth and global cognitive abilities remained significant despite range restriction. Hence, an association between appropriateness of intrauterine growth and global intellectual outcome may be observed even within the population of VLBW preschoolers with adequate standardized birth weight. (JINS, 2012, 18, 200–211)
Identification and Characterization of Two Ca2+/CaM-dependent Protein Kinases Required for Normal Nuclear Division in Aspergillus nidulans *

We utilized an expression screen to identify two novel Ca2+/calmodulin (CaM)-regulated protein kinases in Aspergillus nidulans. The two kinases, CMKB and CMKC, possess high sequence identity with mammalian CaM kinases (CaMKs) I/IV and CaMKKα/β, respectively. In vitro CMKC phosphorylates and increases the activity of CMKB, indicating they are biochemical homologues of CaMKKα/β and CaMKI/IV. The disruption of CMKB is lethal; however, when protein expression is postponed, the spores germinate with delayed kinetics. The observed lag corresponds to a delay in the G1-phase activation of the cyclin-dependent kinase NIMX cdc2 . Disruption ofcmkC is not lethal, but spores lacking CMKC also germinate with delayed kinetics and a lag in the activation of NIMX cdc2 . Analysis of ΔcmkC suggests a role for CMKC in regulating the first and subsequent nuclear division cycles. We conclude that both CMKB and CMKC are required for the proper temporal activation of NIMX cdc2 as spores enter the cell cycle from quiescence and suggest that this relationship exists during the G1/S transition of subsequent cell divisions.
Biphasic decline of β‐cell function with age in euglycemic nonobese diabetic mice parallels diabetes onset

A gradual decline in insulin response is known to precede the onset of type 1 diabetes (T1D). To track age‐related changes in the β‐cell function of nonobese diabetic (NOD) mice, the most commonly used animal model for T1D, and to establish differences between those who do and do not become hyperglycemic, we performed a long‐term longitudinal oral glucose tolerance test (OGTT) study (10–42 weeks) in combination with immunofluorescence imaging of islet morphology and cell proliferation. We observed a clear biphasic decline in insulin secretion (AUC0–30 min) even in euglycemic animals. A first phase (10–28 weeks) consisted of a relatively rapid decline and paralleled diabetes development in the same cohort of animals. This was followed by a second phase (29–42 weeks) during which insulin secretion declined much slower while no additional animals became diabetic. Blood glucose profiles showed a corresponding, but less pronounced change: the area under the concentration curve (AUC0–150 min) increased with age, and fit with a bilinear model indicated a rate‐change in the trendline around 28 weeks. In control NOD scids, no such changes were observed. Islet morphology also changed with age as islets become surrounded by mononuclear infiltrates, and, in all mice, islets with immune cell infiltration around them showed increased β‐cell proliferation. In conclusion, insulin secretion declines in a biphasic manner in all NOD mice. This trend, as well as increased β‐cell proliferation, is present even in the NODs that never become diabetic, whereas, it is absent in control NOD scid mice. © 2015 IUBMB Life, 67(8):634–644, 2015
Malay document clustering using complete linkage clustering technique with Cosine Coefficient

Finding useful and relevant information is a very challenging task to the user. The retrieval system usually responded with a long listed documents which are not necessarily relevant to the user's need. Document clustering is a special technique that can sort out the documents effectively so that documents in the same cluster are similar to each other and documents in different cluster are dissimilar to each other. This paper focuses on document clustering for Malay test collection. It consists of 2028 Malay translated Hadith documents from book Sahih Bukhari. This paper presents the results using Complete Linkage Clustering algorithm with Cosine Coefficient on Malay translated Hadith documents. The evaluation of the experiments uses Recall (R), Precision (P) and Effectiveness (E) measure. The experiments is conducted on 100 clusters, 50 clusters and 20 clusters. It shows that the smaller the size of clusters, Recall (R) will increase, but Precision (P) will decrease. Results for Effectiveness (E) measure compared to the non-clustered documents show that applying clustering algorithm will improved the effectiveness of searching process. For this experiment 20 clusters is rather effective compared to the others.
A new look at Crohn's disease: novel imaging techniques

Purpose of review Imaging the gut provides information on Crohn's disease activity, identifies complications and provides insight into patient symptoms. Imaging can help direct therapy and can predict important patient outcomes. In a rapidly changing, technology-driven field, new imaging applications add novel insights that we are only beginning to appreciate. The purpose of this review is to highlight recent advances in imaging as they are applied to the assessment of patients with Crohn's disease. Recent findings In the past year, key literature describing cross-sectional imaging techniques, including computed tomography (CT) based imaging, specifically CT enterography (CTE) and magnetic resonance enterography (MRE), transcutaneous ultrasound, and PET-based imaging, has emerged in the field of inflammatory bowel disease. MRI sequences that have been recently applied to Crohn's disease assessment, including diffusion-weighted imaging (DWI) and magnetization transfer imaging (MTI), add important new insights. These new data highlight the current status of available imaging modalities and provide a glimpse into the future of our practice. Summary CTE and MRE are our new standard imaging modalities for small bowel Crohn's disease. PET scanning is promising but currently only used routinely in centers with a strong research presence in this area. Ultrasound is emerging as a useful, potentially less costly, radiation-free technique. New MRI sequences offer future promise for effectively monitoring the natural history of Crohn's disease.
An efficient heuristic procedure for solving the state assignment problem for event-based specifications

We propose a novel framework to solve the state assignment problem arising from the signal transition graph (STG) representation of an asynchronous circuit. We first establish a relation between STG's and finite state machines (FSM's). Then we solve the STG state assignment problem by minimizing the number of states in the corresponding FSM and by using a critical race-free state assignment technique. State signal transitions may be added to the original STG. A lower bound on the number of signals necessary to implement the STG is given. Our technique significantly increases the STG applicability as a specification for asynchronous circuits. >
STRONG REDUCTIONS BETWEEN COMBINATORIAL PRINCIPLES

Abstract This paper is a contribution to the growing investigation of strong reducibilities between ${\rm{\Pi }}_2^1$ statements of second-order arithmetic, viewed as an extension of the traditional analysis of reverse mathematics. We answer several questions of Hirschfeldt and Jockusch [13] about Weihrauch (uniform) and strong computable reductions between various combinatorial principles related to Ramsey’s theorem for pairs. Among other results, we establish that the principle $SRT_2^2$ is not Weihrauch or strongly computably reducible to $D_{ < \infty }^2$ , and that COH is not Weihrauch reducible to $SRT_{ < \infty }^2$ , or strongly computably reducible to $SRT_2^2$ . The last result also extends a prior result of Dzhafarov [9]. We introduce a number of new techniques for controlling the combinatorial and computability-theoretic properties of the problems and solutions we construct in our arguments.
Meta architecture to support layered banking systems

In this paper, we have analyzed the need for a meta architecture for banking system in a layered approach with a service oriented architecture (SOA) for e-banking applications. In the layered approach we have classified e-banking tasks into inter-branch, inter-bank and middleware applications thus we can utilize different subarchitectures for different modules while preserving meta architecture
Fuzzy Control System for Autonomous Navigation of Thymio II Mobile Robots

This paper treats the autonomous navigation problem of robotic systems in a dynamic and uncertain environment. In particular, we are interested in determining the robot motion to reach the target while ensuring their own safety and that of different agents that surround it. To achieve these goals, we have adopted a fuzzy controller for navigation and avoidance obstacle, taking into account the changing nature of the environment. The approach has been tested and validated on a ThymioII robots set. As application field, we have chosen a parking problem.
Family Migration and Employment: The Importance of Migration History and Gender

This article uses event history data to specify a model of employment returns to initial migration, onward migration, and return migration among newly married persons in the US. Husbands are more likely to be full-time employed than wives, and being a parent reduces the employment odds among married women. Employment returns to repeated migration differ by gender, with more husbands full-time employed after onward migration and more wives full-time employed after return migration events. We interpret these empirical findings in the context of family migration theory, segmented labor market theory, and gender-based responsibilities.
Thermal modeling of buildings with RC method and parameter estimation

Energy efficiency is becoming more important issue, especially in buildings sector where 15-20% of total energy in developed countries is used. One course toward higher efficiency is to improve HVAC (Heating, Ventilation and Air Conditioning) systems in building, especially by implementation of advanced control methods. Efficiency of these control methods (especially Model Predictive Control) significantly depends on quality of thermal models, where quality can be defined by accuracy and complexity. This paper investigates relationships between accuracy and complexity in thermal models produced with RC (Resistance-Capacitance) equivalent method, with parameters improved using optimization and estimation from data. Four experiments using simulation data regarding importance of selection of error function, selection of training data, selection of model complexity and reduction of complexity are conducted and explained.
[Argon plasma coagulation--a new method in therapeutic endoscopy].

BACKGROUND By argon plasma coagulation (APC), a current is applied to tissues as ionised gas. Special probes have recently been developed for applying the gas through flexible endoscopes. In the field of therapeutic endoscopy, this method is promising for several diseases in the gastrointestinal tract. MATERIAL AND METHODS At Ostfold Hospital in Fredrikstad, Norway, 122 treatments in 80 patients were performed during the years 1997-99. RESULTS The new method was useful for endoscopic treatment of haemorrhages, tumour debulking and tumour ingrowth and overgrowth in oesophageal stents. Abdominal pain was related to insufflation of air and gas. Complications related to the method were not observed. INTERPRETATION Our experience with this new method was very positive. The method was effective, had a very low complication rate, and the equipment was easy to use. The application of APC in premalignant conditions is discussed.
ENTROPIC ATTRACTION AND REPULSION IN BINARY COLLOIDS PROBED WITH A LINE OPTICAL TWEEZER

The long-range entropic forces that arise between two micrometer-sized colloidal spheres in a fluid of much smaller colloidal spheres were directly measured using a line-scanned optical tweezer. This new technique allowed us to measure the functional form of the potential with sub-kBT energy and 15 nm spatial resolution. At the lowest small sphere concentrations, the potential was monotonically attractive, while at higher concentrations an oscillatory potential was observed, due to the liquid structure of the small spheres. Surprisingly, the large spheres came together only rarely at the higher concentrations, suggesting a new means for stabilizing suspensions using entropy alone. [S0031-9007(99)09246-7]
Nurses Leading Care in Custody Suite Environments: A Qualitative Study from Scotland

ABSTRACT This paper outlines the qualitative findings of a recent multimethod study exploring the impact of nurses assuming leadership roles in delivering primary health care to detainees within police custody suites in Scotland. The full multimethod study was conducted within a framework of realistic evaluation with key findings indicating that the nurse-led model of service delivery offers positive outcomes for all key stakeholders. Findings from the qualitative component of the study showed that the quality of clinical care for detainees improved, policing concerns for detainee safety were mitigated, and forensic medical examiners were able to expand their specialist roles. Key supporting mechanisms in achieving these outcomes included generating collaborative practices, enacting clinical leadership, and providing a forensic nursint educational program to empower nurses to generate service provision and grow professional autonomy.