Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of Universities on the Level of Regional Growth in Portugal

Universities nowadays are considered key players in the development of entrepreneurial ecosystems and, thus, may impact regional development. This chapter analyzes the role of the university as a determinant of regional economic growth in Portuguese NUTS III regions, from 2004-2017. One-step and two-step system GMM estimation results show a statistically significant and positive impact of universities upon regional growth. Moreover, the magnitude of effects is transversely stronger in the long run, which requires the need to avoid structural breaks in public actions previously initiated in the past.
A phase 2 study of prostate specific membrane antigen antibody drug conjugate (PSMA ADC) in patients (pts) with progressive metastatic castration-resistant prostate cancer (mCRPC) following abiraterone and/or enzalutamide (abi/enz).

144 Background: PSMA is a validated target that is overexpressed selectively on prostate cancer cells. PSMA ADC is a fully human IgG1 antibody conjugated to the microtubule disrupting agent MMAE which binds to PSMA-positive cells, inducing cytotoxicity. A phase 1 study showed activity and tolerability at doses from 1.8-2.5 mg/kg. We have enrolled 119 mCRPC pts who progressed following abi/enz in a phase 2 trial of PSMA ADC. Methods: mCRPC pts (83 taxane experienced (TE) and 36 chemo-naive (CN)) were administered PSMA ADC 2.5 or 2.3 mg/kg IV Q3 wk for up to 8 cycles. 95% of pts received prior abi and/or enz treatment. Safety, antitumor activity (including PSA, CTCs, and tumor imaging) and exploratory biomarkers were assessed. Results: In all treated pts, PSA declines of ≥30% and ≥50% were 30% and 14%, respectively (n=113); CTC counts showed a decline of ≥50% in 78% of pts and conversion from ≥5 to <5 cells/7.5 ml blood in 47% (n=77) at any time during the study. For 2.3 mg/kg pts (n=82), corresponding PSA .
Scalable deep reinforcement learning for physics-based motion control

This thesis studies the broad problem of learning robust control policies for difficult physics-based motion control tasks such as locomotion and navigation. A number of avenues are explored to assist in learning such control. In particular, are there underlying structures in the motor-learning system that enable learning solutions to complex tasks? How are animals able to learn new skills so efficiently? Animals may be learning and using implicit models of their environment to assist in planning and exploration. These potential structures motivate the design of learning systems and in this thesis, we study their effectiveness on physically simulated and robotic motor-control tasks. Five contributions that build on motion control using deep reinforcement learning are presented. First, a case study on the motion control problem of brachiation, the movement of gibbons through trees is presented. This work compares parametric and nonparametric models for reinforcement learning. The difficulty of this motion control problem motivates separating the control problem into multiple levels. Second, a hierarchical decomposition is presented that enables efficient learning by operating across multiple time scales for a complex locomotion and navigation task. First, reinforcement learning is used to acquire a low-level, highfrequency policy for joint actuation, used for bipedal footstep-directed walking. Subsequently, an additional policy is learned that provides directed footstep plans to the first level of control in order to navigate through the environment. Third, improved action exploration methods are investigated. An explicit action valued function is constructed using the learned model. Using this actionvalued function we can compute actions that increase the value of future states. Fourth, a new algorithm is designed to progressively learn and integrate new
Tankers, Wells, Pipes and Pumps: Agents and Mediators of Water Geographies in Amman, Jordan

Water tankers and private wells along with the municipal piped water system have become an important feature of the techno-social assemblage of water supply in Amman, Jordan. The article takes a theoretically hybrid approach aimed at generating a conversation between actor-network theory (ANT) and the critical-realist and political-economic approaches. We undertake both ANT-inspired and then social-structural analysis of the geography of access to water in Amman. The ANT-based analysis of 'things' like tankers, wells, pipes and pumps draws attention to their relational agency in enabling or constraining access to water. The structural analyses remind us of the enduring class-, genderand geopolitically based power relations that provide the context for the technologies, or things, to work. The key argument is that ANT is useful as a meso-level framework, which may enrich structuralist narratives on geographies of access to water. Specifically, in the case of Amman, Jordan, the inequitable access to water is linked to the history of the Jordanian state, its security imperatives and the technologies that are pressed into service to manage water.
Abscesso hepático piogênico por corpo estranho

Pyogenic hepatic abscess by a foreign body is a rare disease and its diagnosis is habitually made during necropsy. The authors present a case of a woman operated because of a pyogenic hepatic abscess, in the interior of which bristle made of material of vegetable origin were encountered and identified in the laboratory as the principal rib of a leaf, known in Brazil as piacava. The hepatic abscess was drained and the patient was discharged. The probable mechanism for the formation of the hepatic abscess consisted of the accidental ingestion, perforation of the intestines and penetration in the liver.
Exploring the performance of strategy in two-way interactions: an analysis of annual general meetings from a practice perspective

Despite an increasing body of research focusing on two-way interactions in strategy events, more empirical insights are needed to fully understand the performative aspects of such interactions. Based on a video- ethnography drawing on recorded data of Annual General Meetings (AGMs) from seven companies across different industry contexts, we explore how these interactions are strategically performed through particular sets of discursive practices. As an answer to the study's driving research question "How do top managers manage two-way interactions with the audience of an AGM? " we provide details on how an emergent model based on two types of interactions was developed from observed themes and aggregate dimensions. Using that emergent model, we build the argument that the performance of top managers in AGMs during two-way interactions follow certain distinct patterns, and these patterns are determined by how the audience members initiate the interactions.
Manejo odontológico do paciente diabético

O diabetes, atualmente, e uma epidemia que vem crescendo enormemente em todo o mundo, inclusive no Brasil.Ha uma escassa programacao de educacao e de capacitacao profissional em diabetes, assim como uma falta de recursos no controle e na prevencao da molestia. Com essa preocupacao, temos como objetivo esclarecer, atraves de uma revisao bibliografica, alguns topicos importantes a respeito dessa doenca no campo da odontologia, a saber: classificacao dos tipos de diabetes, sinais e sintomas mais comuns, complicacoes encontradas no consultorio odontologico, exames para deteccao da doenca, instrucoes medicamentosas, emergencias, conduta odontologica correta, assim como alteracoes que surgem na cavidade oral dos pacientes diabeticos. Dando enfase as alteracoes na cavidade oral, explanaremos sobre os problemas periodontais desses pacientes especiais: inflamacao gengival, hiperplasia gengival, bolsas periodontais ativas, abcessos recorrentes, perda ossea rapida e progressiva e cicatrizacao lenta do tecido periodontal. Vale salientar que e comum o aparecimento de xerostomia e candidiase oral. Por fim, com a pretensao de atingir nosso publico alvo, que sao cirurgioes dentistas e academicos do curso de odontologia, queremos deixar clara a importância do manejo odontologico correto dos pacientes diabeticos devido a gama de problemas causados por esta molestia. Isso, para que evitemos complicacoes de facil prevencao, bastando, para tal, a observacao dos aspectos peculiares do diabetico (AU)
INTRADUCTAL ULTRASONOGRAPHY FOR THE STAGING OF BILE DUCT CARCINOMA

Intraductal ultrasonography is useful in the staging of extrahepatic bile duct cancer including tumor depth infiltration, pancreatic parenchymal invasion, portal vein invasion, and right hepatic artery invasion. However, it has limitations in assessing lymph node metastases. The assessment of longitudinal cancer extension along the bile duct is a promising aspect of this area. However, a thickening of the bile duct wall may represent either inflammatory changes that may result from mechanical irritation by a biliary drainage catheter or other factors, or the longitudinal extension of the cancer.
Synthesis of High Aspect-Ratio Gold Nanowires with Highly Porous Morphology

Here, we demonstrate the formation of porous gold nanowires with diameters <60 nm by a two-step process involving the successive electrodeposition of silver then gold into the pores of a track-etched polycarbonate filtration membrane, followed by treatment with nitric acid. The resulting nanowires possess a unique, highly porous morphology, which yields a very high accessible surface area to volume ratio compared to solid nanowires of the same dimensions. Combined with the high aspect ratio of these particles (which allows for easy isolation from solution), this makes them eminently suitable for use in catalysis and sensing applications. The formation of such porous gold nanostructures was ascertained to result from the low diffusivity of the silver species within the narrow membrane pores.
Virtual bronchoscopy guidance system for transbronchial needle aspiration

A system for planning transbronchial needle aspiration (TBNA) based on high-resolution chest CT is presented, comprising 2D axial, coronal or sagittal views and a 3D perspective intra-luminal view of the airways. The biopsy site can be defined interactively on the 2D views, and is displayed as 3D object across the translucent bronchial wall. Reference points can be placed on anatomical landmarks like the carina, which allows measuring 3D distances to viewpoints or to other landmarks. Orientation of the targets can be estimated based on a consistent orientation of the virtual endoscopic view. The system can be used as a pre-interventional planning tool, or simultaneously during the biopsy, in order to select the optimal needle insertion points. The system does not provide registration between the virtual and the real images, and does not require special hardware for tracking or any modifications of the bronchoscope. A phantom study comprising three bronchoscopists with different levels of experience showed a significant increase in yield compared to the traditional procedure based on axial CT images alone.
Healthcare Services Quality In The Rural Health Centres And Its Impact On Nigeria Citizens

Empowering patients and understanding their views should be central to activities at the Pri-mary Health Care Level. This is because community cooperation and involvement is a high priority of the primary Health Care. This study, based on administered questionnaire to users of primary Health Care examines Patients/ Users view of quality of care at the primary level in other to assist care pro-viders to be more responsive to patients needs and, hence, deliver better quality of care. The study employed an additive compensatory model to integrate and stratify respondent’s responses and then subsequently correlate key service quality attribute to determine association. The findings suggest the need to emphasize ‘empathy’ for care providers and the provision of a reasonable level of physical fa-cilities to encourage care seekers/ users to place ‘faith’ in primary facilities and hence capacity utilization at the primary level facilities
MARS: the electronic medical record system: the core of the Kaiser galaxy

The growth of e-commerce (electronic commerce) is vast, complex and rapidly expanding. E-commerce is clearly an integral part of business, spreading across the areas of Business to Consumer, Business to Business, e-government and e-health. In fact, we could be forgiven for thinking we are in the e-millennium. E-medical records are an example of one such e-initiative to touch the healthcare sector. However, the true advantages of these e-medical records are not clear. We present the case example of MARS, the automated medical record system at Kaiser Permanente-Ohio. In so doing we show that the true advantage of this system is that it functions as a knowledge management system (KMS) simultaneously enabling and facilitating convergence and compliance of healthcare treatment as well as enhancing and supporting the creation and renewal of knowledge pertaining to healthcare delivery.
A pilot study to assess the effects of life coaching with Year 12 students

A pilot study was conducted to assess the effects of life coaching on Year 12 students’ personal and academic development, specifically evaluating emotional well being, problem solving ability, relationships and academic performance. Students were randomly selected from consenting students within pastoral care groups. Two control groups of matched students were then selected from consenting students and from students who elected not to participate in the coaching. Data were collected from all students early in the year, before coaching and at a mid year point. No significant differences on any of the measures were found. Further data collection points will be at the end of twelve months and a follow-up one year after the students have left school.
Surgical safety: Can a checklist really save lives?

ABSTRACT Following the Safe Surgery Saves Lives campaign (WHO, 2008), surgical safety checklists (SSCs) were introduced into human operating theatres as a tool to reduce the risk of preventable complications during the perioperative period. The SSC has been largely successful in reducing such incidents in the human field. The use of veterinary SSCs is currently limited, although the benefits of SSCs are likely to be transferable to the veterinary practice. This article discusses the introduction of an SSC into practice and its potential use as a clinical auditing tool.
Suggested Methods for the Standardisation of the Carcinogenic Activity of Different Agents for the Skin of Mice

Since the discovery of Yamagiwa and Ichikawa that skin cancers could be induced in mice by the repeated application of gas tars, the number of animals utilised for testing the carcinogenic activity of different agents has steadily grown from year to year. Many of the experiments have been performed with a view to ascertaining what factors inhibit and what factors increase or hasten the yield of tumours, but when one attempts to analyse the experimental results available in the literature, it is often a matter of extreme difficulty to correlate the experiments of one worker with those of another. This difficulty is due in part to the variety of methods adopted by many workers when giving expression to their results, but usually in greater part to the inadequacy of the data given by the poor methods generally adopted. It seems a matter of real importance that the results of different workers should be readily comparable one with another, and it is the urgent need for standardisation of results which has stimulated us to make a closer study of this subject. The object of this paper is to place before other cancer research workers some analyses of a variety of experiments on carcinogenesis, in the hope that one or other of the suggested methods, or some modification of them, may find favour, and be generally utilised to express the results of experiments of the class now under consideration.
Medico-Legal Evaluation of Violence Against Pregnant Women Attending Woman’s Health Hospital in Assiut University, Upper Egypt

Violence against women is the most persistent yet under-recognized human rights violation and is an important worldwide health problem. Pregnant women may be especially susceptible to violence owing to increasing their physical, social, emotional and economic demands during pregnancy with potential negative health impacts on both the mother and her unborn baby. Alongside diagnosis and treatment processes, there are considerable challenges in medico-legal evaluation of domestic violence against pregnant women. The present study was carried out to estimate the frequency and pattern of domestic violence among pregnant women in Assiut governorate and to identify the associated socio-demographic and behavioral risk factors. Meanwhile, investigation of the relationship between pregnant women’s health status and violence exposure was another important goal. A cross-sectional study design using a random sampling method was employed in this study. The sample comprised 296 pregnant women aged 18-45 years old who were attending Woman’s Health Hospital in Assiut University for antenatal care. Data was collected via a structured interview questionnaire including the socio-demographic and personality characteristics of the women and their husbands in addition to family profile. The questionnaire also assessed different forms of domestic violence and its consequences on general and obstetric well-being of the pregnant women. Results revealed that the overall prevalence of domestic violence among the studied group was exceptionally high (91.2%); the commonest form was psychological abuse (81.8 %), followed by sexual abuse (35.5%) and lastly physical abuse (28 %). Logistic regression analysis indicated that younger wives with low educational attainment, non-religious and violent husbands in addition to nuclear and poor families, were all linked to domestic violence against pregnant women. Regarding the health consequences of violence exposure, the urinary and gynecological adverse effects were most common, with a statistically significant difference in each form of violence. In conclusion, the overall prevalence of domestic violence within the pregnant women sample in Upper Egypt was remarkably high and predominantly of psychological form. Several risk factors have been identified. Pregnant women abuse had adverse health effects that urge raising awareness of obstetricians and health workers in prenatal and family planning services about their legal and ethical responsibilities regarding diagnosis of women abuse through sound examination protocols.
Family Influences on Youth Alcohol Use

Abstract This study examined the effects of demographic and family influences on alcohol use among White and African American youth. Data comprised 400 target youth with a mean age of 11.04 years (SD = 1.68), 51.2% male, 49.8% African American and 50.2% White. Youth alcohol use was hypothesized to be influenced by the child's age, family income, parent status, parent alcohol use, sibling alcohol use, and family cohesion. A four-group multiple-sample structural equation model examined means and relations across ethnicities and genders. Parent and sibling use were significant predictors of target youth alcohol use. Parent status influenced sibling alcohol use, and family cohesion. Income was related to parent alcohol use. Despite a few structural and mean differences, the overall model was consistent across the four groups.
Long‐term safety of filgrastim (rhG‐CSF) administration: response to Confer & Miller and Bacher & Zander

Bennett, C.L. , Evens, A.M., Andritsos, L.A. , Balasubramanian, L. , Mai, M. , Fisher, M.J., Kuzel, T.M. , Angelotta, C. , McKoy, J.M. , Vose, J.M. , Bierman, P.J., Kuter, D.J., Trifilio, S.M. , Devine, S.M. & Tallman, M.S. (2006) Haematological malignancies developing in previously healthy individuals who received haematopoietic growth factors: report from the Research on Adverse Drug Events and Reports (RADAR) project. British Journal of Haematology, 135, 642–650. Goldman, J.M. , Madrigal, J.A. & Pamphilon, D. (2006) Possible harmful effects of short course granulocyte colony-stimulating factor in normal donors. British Journal of Haematology, 135, 651–652. Horowitz, M.M. & Confer, D.L. (2005) Evaluation of hematopoietic stem cell donors. American Society of Hematology Program Book, 1, 469–475. Niederwieser, D.W. , Appelbaum, F.R. , Gastl, G. , Gersdorf, E. , Meister, B. , Geissler, D. , Tratkiewicz, J.A. , Thaler, J. & Huber, C. (1990) Inadvertent transmission of a donor’s acute myeloid leukemia in bone marrow transplantation for chronic myelocytic leukemia. New England Journal of Medicine, 322, 1794–1796. Pulsipher, M.A., Levine, J.E. , Hayashi, R.J., Chan, K.W. , Anderson, P., Duerst, R. , Osunkwo, I. , Fisher, V. , Horn, B. & Grupp, S.A. (2005) Safety and efficacy of allogeneic PBSC collection in normal pediatric donors: the pediatric blood and marrow transplant consortium experience (PBMTC) 1996–2003. Bone Marrow Transplantation, 35, 361–367. Smith, M.L. , Cavenagh, J.D. , Lister, T.A. & Fitzgibbon, J. (2004) Mutation of CEBPA in familial acute myeloid leukemia. New England Journal of Medicine, 351, 2403–2407.
Tingkat Pengetahuan dan Kesadaran Karyawan terhadap Penerapan Sistem Manajemen Lingkungan (SML) ISO 14001:2004 di PT Garuda Metalindo

Sistem Manajemen Lingkungan (SML) ISO 14001 merupakan standar yang diterapkan secara internasional untuk pengelolaan lingkungan hidup. Salah satu perusahaan yang menerapkan ISO 14001 ini adalah PT Garuda Metalindo. Penelitian ini dilakukan untuk mengetahui tingkat pengetahuan dan kesadaran Karyawan PT Garuda Metalindo terhadap penerapan SML ISO 14001:2004. Penelitian dilakukan dengan menyebarkan kuisioner kepada 127 orang Karyawan yang masing-masing terdiri dari 2 orang dari level top manajemen, 4 orang dari level middle manajemen, dan 121 dari tingkat pelaksana. Kuisioner terdiri dari sepuluh (10) pertanyaan, untuk level top dan middle manajemen jawaban pertanyaan berdasarkan prioritas dan tingkat pelaksana memilih salah satu jawaban yang dianggap benar. Tingkat pengetahuan dan kesadaran level top dan middle manajemen berkisar antara 82,04% sampai 89%, dan untuk tingkat pelaksana sebesar 72%. Namun, masih diperlukan tindakan perbaikan terhadap penerapan SML ISO 14001:2004, khusunya untuk klausul 4.4. 3 tentang Komunikasi yang belum diterapkan secara maksimal di Perusahaan ini.Kata kunci: Pengelolaan lingkungan, Sistem Manajemen Lingkungan, Pengetahuan, Kesadaran lingkungan, ISO14001.