Miracle-dz/UniFAR-FTUs huggingface dataset:
Counseling and motivational short text messages increase adherence and behavioral changes in patient with hypertension

Background : Patients with hypertension often fail to achieve treatment goals of controlling their blood pressure, hence they fall onto the condition of uncontrolled hypertension. In addition to counseling and patient-education programme, an enhanced methods of intervention is needed by pharmacist to increase patient adherence and commitment in taking antihypertension medicine. Motivational intervention has not been widely used by pharmacist in conducting pharmaceutical care to patients. Objective : This research is aimed to understand the effect of motivational counseling and short text messages (SMS) with adherence and behavioral changes in outpatient with hypertension at PKU Muhammadiyah Hospital Bantul, Yogyakarta. Methods : Sixty patients who meet the inclusion criteria was divided into two groups, which were experimental group (n=30) who received motivational counseling and SMS, and control group (n=30) who received usual care. Data was collected by interviews, behavioral questionaire, adherence questionaire using Morisky Medication Adherence Scale (MMAS), and blood pressure measurement according to the medical record. Results : Trans theoretical model (TTM) was used in this research. Stages of behavioral changes were divided into pre-contemplation, contemplation, preparation, and action. Result showed that pharmacist intervention, using motivational counseling and SMS as reminder, contribute to an increase of patient adherence and action stage of behavioral changes in the experimental group by 50% compared to 20% in the control group (p=0,035). Increase of adherence as much as 83,33% was seen in experimental group (p=0,000). A bigger decrease of systolic and diastolic blood pressure (SBP/DBP) was also seen in the experimental group compared to control group (SBP=15,37 vs 1,27mmHg), (DBP=6,73 vs 0,43 mmHg) on their second visits. Conclusion : Based on these results, it can be concluded that motivational counseling with SMS as a reminder and motivation by pharmacists in hypertensive patients give a positive influence on behavioral changes that improve adherence, and increase of systolic and diastolic blood pressure control.
The Pristine survey – XX: GTC follow-up observations of extremely metal-poor stars identified from Pristine and LAMOST

Ultra metal-poor stars ($\rm {[Fe/H]} < -4.0$) are very rare, and finding them is a challenging task. Both narrow-band photometry and low-resolution spectroscopy have been useful tools for identifying candidates, and in this work we combine both approaches. We cross-matched metallicity-sensitive photometry from the Pristine survey with the low-resolution spectroscopic LAMOST database, and re-analysed all LAMOST spectra with $\rm {[Fe/H]} _{\it Pristine} <-2.5$. We find that ∼1/3rd of this sample (selected without $\rm {[Fe/H]} _{\it Pristine}$ quality cuts) also have spectroscopic $\rm {[Fe/H]} < -2.5$. From this sample, containing many low signal-to-noise (S/N) spectra, we selected eleven stars potentially having $\rm {[Fe/H]} < -4.0$ or $\rm {[Fe/H]} < -3.0$ with very high carbon abundances, and we performed higher S/N medium-resolution spectroscopic follow-up with OSIRIS on the 10.4m Gran Telescopio Canarias (GTC). We confirm their extremely low metallicities, with a mean of $\rm {[Fe/H]} = -3.4$ and the most metal-poor star having $\rm {[Fe/H]} = -3.8$. Three of these are clearly carbon-enhanced metal-poor (CEMP) stars with $+1.65 < \rm {[C/Fe]} < +2.45$. The two most carbon-rich stars are either among the most metal-poor CEMP-s stars or the most carbon-rich CEMP-no stars known, the third is likely a CEMP-no star. We derived orbital properties for the OSIRIS sample and find that only one of our targets can be confidently associated with known substructures/accretion events, and that three out of four inner halo stars have prograde orbits. Large spectroscopic surveys may contain many hidden extremely and ultra metal-poor stars, and adding additional information from e.g. photometry as in this work can uncover them more efficiently and confidently.
An Empirical Review of Data Mining Applications

— Data mining has remained an active and challenging field of research and is been a branch of applied artificial intelligence. Several data mining techniques and their applications have been developed during past two decades. This survey article deals with some of the data mining techniques and typical applications. Based on the application/challenge to be addressed single or combination of technique is employed. The article briefly discusses some of the typical application of data mining domain to showcase the extent of the contribution of data mining in the modern era of digitization. The article discusses and concludes some of the modern open-source tools that might help researches/students interested in data mining domain.
Multi-attribute Bayesian optimization with interactive preference learning

We consider black-box global optimization of time-consuming-to-evaluate functions on behalf of a decision-maker (DM) whose preferences must be learned. Each feasible design is associated with a time-consuming-to-evaluate vector of attributes and each vector of attributes is assigned a utility by the DM's utility function, which may be learned approximately using preferences expressed over pairs of attribute vectors. Past work has used a point estimate of this utility function as if it were error-free within single-objective optimization. However, utility estimation errors may yield a poor suggested design. Furthermore, this approach produces a single suggested "best" design, whereas DMs often prefer to choose from a menu. We propose a novel multi-attribute Bayesian optimization with preference learning approach. Our approach acknowledges the uncertainty in preference estimation and implicitly chooses designs to evaluate that are good not just for a single estimated utility function but a range of likely ones. The outcome of our approach is a menu of designs and evaluated attributes from which the DM makes a final selection. We demonstrate the value and flexibility of our approach in a variety of experiments.
Rethinking Temporal Object Detection from Robotic Perspectives

Video object detection (VID) has been vigorously studied for years but almost all literature adopts a static accuracy-based evaluation, i.e., average precision (AP). From a robotic perspective, the importance of recall continuity and localization stability is equal to that of accuracy, but the AP is insufficient to reflect detectors' performance across time. In this paper, non-reference assessments are proposed for continuity and stability based on object tracklets. These temporal evaluations can serve as supplements to static AP. Further, we develop an online tracklet refinement for improving detectors' temporal performance through short tracklet suppression, fragment filling, and temporal location fusion. In addition, we propose a small-overlap suppression to extend VID methods to single object tracking (SOT) task so that a flexible SOT-by-detection framework is then formed. Extensive experiments are conducted on ImageNet VID dataset and real-world robotic tasks, where the superiority of our proposed approaches are validated and verified. Codes will be publicly available.
Nonadiabatic exciton-phonon coupling in Raman spectroscopy of layered materials

We develop a new computational approach to resonant Raman scattering to study nonadiabatic exciton-phonon scattering. We present an ab initio computational approach for the calculation of resonant Raman intensities, including both excitonic and nonadiabatic effects. Our diagrammatic approach, which we apply to two prototype, semiconducting layered materials, allows a detailed analysis of the impact of phonon-mediated exciton-exciton scattering on the intensities. In the case of bulk hexagonal boron nitride, this scattering leads to strong quantum interference between different excitonic resonances, strongly redistributing oscillator strength with respect to optical absorption spectra. In the case of MoS2, we observe that quantum interference effects are suppressed by the spin-orbit splitting of the excitons.
Cytologic evaluation of pulmonary effluent in neonates with respiratory distress syndrome and bronchopulmonary dysplasia.

: Tracheobronchial effluent from 108 infants with respiratory distress syndrome (RDS) was classified cytologically in relationship to the duration of endotracheal intubation and mechanical ventilation with supplemental oxygen. Three cytologic classes emerged: class I (1 to 4 days), associated with exfoliation of cohesive and organized sheets of tracheobronchial cells, class II (4 to 10 days), during which regeneration of tracheobronchial cells was prominent and reactive cells were present, and class III (after 10 days), during which squamous metaplasia, chronic inflammation and regeneration were characteristic. An influx of polymorphonuclear neutrophilic leukocytes and macrophages was typical of classes II and III. In 70% of the cases, the identification of class III changes enabled the diagnosis of bronchopulmonary dysplasia (BPD) to be made earlier than by radiography alone. This classification of tracheobronchial cytology should be of benefit in the identification and treatment of infants with bronchopulmonary dysplasia. It may also offer a more direct means for evaluating new therapy to prevent or modify this disorder.
НАДЕЖНОСТЬ И ВАЛИДНОСТЬ РУССКОЯЗЫЧНОЙ ВЕРСИИ ШКАЛЫ DS14 У БОЛЬНЫХ ИШЕМИЧЕСКОЙ БОЛЕЗНЬЮ СЕРДЦА

Aim. The aim of the study is to evaluate the factorial, construct validity and reliability of the Russian version of DS14 score among ischemic heart disease patients (IHD). Material and methods. Totally, 977 IHD patients included (334 with acute coronary syndrome and 643 with stable angina), all patients fully completed the questionnaires DS14, HADS, MSPSS and STPI. Results. The prevalence of type D among IHD patients was 31,6%. Bifactorial structure of DS14 (negative affectivity, social suppression) was confirmed by exploratory and confirmatory factor analysis, and the parameters of intrinsic relative homogeneity, Tacker-Lewis index, incremental index of relation and meanquartile approximation bias for bifactorial solution were 0,90, 0,88, 0,90 and 0,069, respectively, that witnesses on the matching of theoretical bifactorial model with experiment. Intrinsic homogeneity of the Russian version of DS14 was adequate. Cronbakh alpha for negative affectivity was 0,78, for social suppression 0,74. Mean value for correlated points for negative affectivity was 0,35, for social suppression — 0,30, that confirms the adequacy of intrinsic structure of DS14. It was found, that the negative affectivity scale positively correlates with anxiety by HADS and anxiety as personal trait by STPI, and with depression by HADS and depressivity by STPI. The same, but less prominent relations were established for social inhibition. Also there was negative correlation of openness and positive correlation with aggressiveness as personal traits by STPI. Conclusion. Russian version of DS14 matches with the English version by reliability and intrinsic structure, construct validity is confirmed by the results of correlational analysis. In general, the method can be applied for personality type D assessment in IHD patients.
Cardiac 123 I-MIBG Parameters at 4 Hours Derived from Earlier Acquisition Times

Background: The clinical implementation of cardiac 123 Iodine-meta-iodobenzylguanidine ( 123 I-MIBG) scintigraphy for the evaluation of prognosis in patients with heart failure (HF) is still limited. This may partially be related to the long examination time with an almost 4 hour delay between the early and late acquisition. Additionally, outcome derived at different late acquisition times cannot be compared with each other. To assess whether earlier acquisition time of the late image is justified, the aim of present study was to evaluate in a HF patient cohort whether a developed direct comparison method for cardiac 123 I-MIBG imaging enables comparison of washout rates and late heart-to-mediastinum (H/M) ratios from 1 to 3 hours post injection (pi) with measurements at 4 hours pi. Methods: Forty-eight patients with HF were clinically referred for cardiac 123 I-MIBG scintigraphy. The washout rate and late H/M ratio at 4 hours pi were estimated with a previous published linear model from heart and mediastinal counts at 1, 2 and 3 hour pi and compared with the actual values at 4 hour pi. Results: The estimated washout rate and late H/M ratio at 4 hours pi from counts at 1 hour pi demonstrated large differences. However, the average estimated late H/M ratio at 4 hours pi derived from 2 and 3 hours pi did not differ with the actual late H/M ratio at 4 hours pi (P=0.84 and P=0.06). As well as, the actual washout rate at 4 hours pi and estimated washout rate at 4 hours pi derived from 3 hours pi did not differ significantly (P=0.22). Yet, the mean estimated washout rate at 4 hours pi derived from the acquisition at 2 hours pi showed a difference compared with the actual washout rate at 4 hours pi (25±19 vs. 34±17, P<0.001). Conclusions: The direct comparison method for cardiac 123 I-MIBG imaging enables accurate estimation of the actual late H/M ratio and washout rate at 4 hours pi derived from the acquisitions at 3 hours pi. The acquisition at 2 hours pi should only be performed in exceptional cases when clinically necessary because of the existing difference between the actual and estimated washout rate at 4 hours pi derived from 2 hours pi.
Meditation as a Useful Chance for Chronic Pain Decrease

Study background: The aim of this study was the investigation the role of meditation in a cohort of Italy resident subjects coming from Thailand, following only complementary medicine. Methods: The cohort of subjects has been examined (60 subjects) by the visual analogue scale (VAS) scale for pain measurement. The subjects have been divided in two groups: experts (>10 years) and Lower experts in meditation (<3 years). All the subjects were affected by chronic pain due to osteoarthritis of the knees and low back pain. Results: 28 subjects with chronic pain reported a mean basal VAS of 5.1 ± 1.8. After 5 consecutive days of meditation, the expert in meditation reported a significant pain decreasing (p<0.01) (VAS 3.0 ± 0.5) compared to the basal evaluation, while the lower experts in meditation reported a not significant decreasing of pain. Conclusions: Meditation is nowadays a practice that should be highly recommended within a nonpharmacological approach for chronic pain therapy. This study it is further evidence that meditation might be a valuable strategy for chronic pain patients.
Diamond Beamline I16 (Materials & Magnetism)

We describe the key features and performance specifications of a facility for high‐resolution single‐crystal x‐ray diffraction at Diamond Light Source. The scientific emphasis of the beamline is materials‐ and x‐ray‐physics, including resonant and magnetic scattering. We highlight some of the more novel aspects of the beamline design.
Centralised Biological Therapy Registry for Moderate to Severe Plaque Psoriasis – Overview and Methodology

Abstract The introduction of new pharmacotherapy entities in the last decade accentuate the necessity to set up treatment guidelines based on real life evidence. Randomized controlled trials remain golden standard of a research. Data derived from studies aiming on daily clinical practice should bring needed, added value. Disease prevalence growth, due to increased life expectancy, better diagnostic procedures and earlier medical intervention, as well as ever growing demand for highly priced, sophistically produced drugs put stress on healthcare budgets even in developed countries. Large databases commonly called - therapy registries are implemented to collect data on therapy effectivity in terms of effectiveness, safety and patient long-term on therapy survival. Registries importance rose together with biological therapies introduction. New in class molecules entered the market conditionally being obliged to provide additional e.g. safety data. Such procedures require involvement of many different professionals, e.g. physicians, professional medical bodies, IT experts, database administrators, statisticians and government institutions. Paper based, followed by computer based forms were distributed among physicians to collect these data. eHealth technologies provide physicians with centralized, more intuitive applications. The particularities of different diagnosis caused great variations within each specific registry launched. Important information was missing since they were pointed out as optional and many were redundant causing frustration among physicians due to inadequate administrative workload. The main objective of this work was to set up the therapy registry standards and procedures. Methodology of „ideal“ moderate to severe plaque psoriasis biology therapy registry development, introduction, administration and evaluation was prepared to assist any government institution or professional body when planning registry deployment. Electronic application based on widely used MS Excel platform was developed and installed in the biological therapy centers as a standalone application for the pilot use.
Detection of Protein BCL2/JH Rearrangement in Epidermoid Carcinomas of Mouth and Pharynx

Summary Introduction: The BCL2 protein found in the internal mothocondrial membrana regulates the apoptosis preventing the programmed cell death. The translocation (14:18), detected in 70 to 85% of the follicular lymphoma, lead the super expression of BCL2 protein, by juxtaposition of BCL2 gene to the JH segment of the immunoglobulins' heavy chain gene. However, the found of the BCL2 expression in head and neck carcinoma are contradictious. Objective: To investigate the presence of the translocation (14:18) of the BCL2 gene in head and neck carcinoma. Method: Sixteen DNA samplers were examinated being 13 of squamous cells carcinoma (SCC) and 3 of epidermoid (CE), y means of chain reaction of the polymerase (PCR). Results: The BCL2/JH rearrangement in 2 (15%) of the CCE 13 cases and in none of the 3 cases of CE. The average of the frequency of molecules with rearrangement was 46,44 × 107. Was not observed association between the rearrangement presence and the exhibition to tobacco and alcohol (p = 0, 6545). Conclusion: Different from the results found in follicular lymphoma, the presence of the translocation (14; 18) in head and neck carcinomas is not common and, when it occurs, it can be an occasional mutation not associated to exhibition to the tobacco and alcohol.
Cost-effectiveness of magnetic resonance imaging of the knee for patients presenting in primary care.

BACKGROUND Musculoskeletal problems generate high costs. Of these disorders, patients with knee problems are commonly seen by GPs. Magnetic resonance imaging (MRI) of the knee is an accurate diagnostic test, but there is uncertainty as to whether GP access to MRI for these patients is a cost-effective policy. AIM To investigate the cost-effectiveness of GP referral to early MRI and a provisional orthopaedic appointment, compared with referral to an orthopaedic specialist without prior MRI for patients with continuing knee problems. DESIGN OF STUDY Cost-effectiveness analysis alongside a pragmatic randomised trial. SETTING Five-hundred and thirty-three patients consulting their GP about a knee problem were recruited from 163 general practices at 11 sites across the UK. METHOD Two-year costs were estimated from the NHS perspective. Health outcomes were expressed in terms of quality-adjusted life years (QALYs), based on patient responses to the EQ-5D questionnaire administered at baseline, and at 6, 12, and 24 months' follow-up. RESULTS Early MRI is associated with a higher NHS cost, by £294 ($581; €435) per patient (95% confidence interval [CI] = £31 to £573), and a larger number of QALYs, by 0.050 (95% CI = −0.025 to 0.118). Mean differences in cost and QALYs generated an incremental cost per QALY gained of £5840 ($11 538; €8642). At a cost per QALY threshold of £20 000, there is a 0.81 probability that early MRI is a cost-effective use of NHS resources [corrected]. CONCLUSION GP access to MRI for patients presenting in primary care with a continuing knee problem represents a cost-effective use of health service resources.
Hypoglycemic Action of Seed Kernel of Caesalpinia bonducella Fleming In Normal and Alloxan- Induced Diabetic Albino Rats

The aim of the present study is to evaluate the hypoglycemic action of ethanolic extract of seed kernel of Caesalpinia bonducella Fleming on normal and alloxan-induced diabetic albino rats. The ethanolic extract (200mg/kg/d) was administered orally for two weeks to alloxan-induced diabetic rats. Blood glucose was estimated every week for two consecutive weeks along with body weight monitoring. For evaluation of mechanism of action of test drug, glycogen estimation was done in liver, heart and skeletal muscle and effect on adrenaline-induced hyperglycemia was seen. The test drug significantly (p<0.05) reduced the rise in blood glucose induced by alloxan. The test drug produced significant (p<0.05) increase in liver glycogen and also significantly (p<0.05) reduced adrenaline-induced hyperglycaemia. Significant (p<0.05) lowering of normal blood glucose was also found. Thus, the seed kernel of Caesalpinia bonducella has significant antidiabetic and hypoglycemic activity.
Functional outcomes : The development of a new instrument to monitor the effectiveness of physical therapy

The purpose of this methodological study was to evaluate the reliability, internal consistency, and sensitivity of a new self-report functional outcomes profile, the California Functional Evaluation 40 (CAFE 40). The CAFE 40 contains 3 sections: 1. Section I: General health and activity level rated on an ordinal scale; 2. Section II: Independence-assistance needed rated on an ordinal scale; and 3. Section III: Endurance (specific listing of the patient reported amount of time that can be spent at a specific task such as walking, sitting, writing). In this study, Sections I and II were evaluated. Section III was rarely completed by the patients or normal subjects. 38 patients from 5 physical therapy outpatient clinics and 64 healthy adults participated in the reliability study by completing the functional profile twice within a 2 day interval. Test-retest reliability for the total profile score was high (r ic = 0.971). Internal consistency (the correlation between each item and the total section score reaching 0.5 or better) was acceptable for all but one item each in Section I and II (with the Spearman Rank Correlation Coefficient ranging from 0.408 to 0.82 in Section I and 0.463 to 0.748 in Section II). 45 patients participated in the sensitivity study where the subjects completed the CAFE 40 at each physical therapy visit. A significant positive linear trend of improvement was noted (p < 0.001, Page Test). The last score was significantly higher than the first score for both Section I and II (p < 0.001 respectively as measured by Paired Wilcoxon Test). The results indicate that Sections I and II of the CAFE 40, have acceptable reliability, internal consistency, and sensitivity for measuring functional outcomes in healthy adults and patients receiving outpatient physical therapy. A revised profile is currently available for continued test development and broader application. Professionals in rehabilitation are encouraged to use this functional outcomes tool in their outpatient practices and send comments to the California Research Special Interest Group for continued improvement in the questionnaire.