Miracle-dz/UniFAR-FTUs huggingface dataset:
Apprentissage d'ordonnancement et influence de l'ambiguïté pour la prédiction d'activité sur les réseaux sociaux

Forecasting keyword/topic activities in social networking sites has been the subject of many recent studies, as such activities represent, in many cases, a direct estimate of the spreadth of real-world phenomena, it eg. box-office revenues or flu epidemies. Most of these studies rely on pointwise, regression-like prediction algorithms and focus on few, usually unambiguous, keywords/topics. We study different strategies to rank keyword activities through a comparison of pointwise and pairwise learning to rank approaches, as well as the impact of keyword ambiguity, keyword activity and keyword set size on the prediction results. It is the first time, to our knowledge, that such dimensions are evaluated in this framework. Our experiments are conducted on a large dataset built by monitoring Twitter over a year and including 1497 keywords.
Application of surface plasmon resonance of citrate capped silver nanoparticles for the selective determination of some fluoroquinolone drugs

Article history: Received on: 15/10/2016 Accepted on: 07/11/2016 Available online: 27/02/2017 Citrate capped silver nanoparticles (Ag NPs) was used as a colorimetric probe for the sensitive determination of six drugs belongs to fluoroquinolone family (Ciprofloxacin, Lomefloxacin, Ofloxacin, Pefloxacin, Levofloxacin and Moxifloxacin). The interaction between the studied fluoroquinolones and citrate-capped Ag NPs resulted in the appearance of new surface plasmon resonance (SPR) peaks measured in the range of 598 – 696 nm. Under the optimized conditions, good linear relationships (R 2 = 0.9973–0.9991) were obtained in the range of 1.50– 10.25 , 2.0–10.25, 2.0–10.50, 2.0–10.50, 1.5–10.0 and 2.0–11.0 μg/mL for Ciprofloxacin, Ofloxacin, Levofloxacin, Moxifloxacin, Lomefloxacin and Pefloxacin, respectively. The analytical performance of the method was fully validated, and the results were satisfactory. Different pharmaceutical dosage forms containing the cited drugs were successfully analyzed by the suggested method with high degree of accuracy and precision. The proposed method is environmentally safe as it use water as a solvent and does not involve solvent extraction.
Pharyngeal Swallowing in Patients with Paresis of the Recurrent Nerve

Pharyngolaryngeal function during swallowing was investigated cineradiographically in 22 patients with paresis of the recurrent nerve. Nineteen of these patients (86%) had defective closure of the laryngeal vestibule: 10 patients had defective apposition of the corniculate cartilages, (paresis of the oblique cricoarytenoid muscle), 9 patients had defective apposition of the arytenoid cartilages, (paresis of the interarytenoid muscle), 13 patients had defective movement of the epiglottis (paresis of, i.a. the thyrohyoid muscle), 1 patient had defective closure of the subepiglottic portion of the vestibule (paresis of the thyroepiglottic muscle), 2 patients had defective closure of the supraglottic portion of the vestibule (paresis of the superior ventricular segment of the thyroarytenoid muscle). Five patients with immobility of the epiglottis also had paresis of the pharyngeal constrictor musculature indicating paresis of the superior laryngeal nerve. Our investigation has shown that patients with paresis of the recurrent nerve who present with dysphagia with or without aspiration should be examined cineradiographically for pharyngolaryngeal function during swallowing.
Toxicity of Bisphenol-A: Effects on Health and Regulations

: Bisphenol-A (BPA) is one of the highest volume chemicals produced worldwide in the plastic industry. This compound is mostly used in producing polycarbonate plastics that are often used for food and beverage storage, and BPA is also a component of epoxy resins that are used to line food and beverage containers. Studies performed in this area indicated that BPA could be extracted from such products while they are in contact with food. Therefore, BPA exposure is presumed. In this paper, the chemical structure of BPA, factors affecting BPA migration to food and beverages, effects on health, and recent regulations will be reviewed.
Comparative evaluation of Tunnel-FET ultra-low voltage SRAM bitcell and impact of variations

In this paper, the advantages and the challenges posed by Tunnel FETs (TFETs) are studied in the context of ultra-low voltage SRAM bitcells operating below 500 mV. A comparative analysis of TFETs, SOI and bulk CMOS in 32 nm technology is performed through device- (TCAD) and circuit-level (VerilogA) simulations. Sensitivity to the key device parameters is analyzed to quantitatively evaluate the impact of the corresponding variations. Interestingly, our analysis shows that TFETs are less sensitive than SOI/bulk to device parameters that are affected by the gate pitch. Hence, TFETs can help mitigate the printability issues in 32-nm technologies and beyond.
Assessment of Carbohydrates , Vitamins and Free Amino Acids in Seeds , Peels and Pulps of Guddaim ( Grewia tenax . Forssk ) Fiori Fruits

Free amino acids, vitamins and sugar contents of Guddaim fruits (seeds peels and pulps) were studied. Pulps exhibited lower values in carbohydrate contents than peels and seeds, fat and protein contents were high in the seeds more than peels and pulps. The total energy values of seeds, peels and pulps were 303.4, 306.7 and 364.5 Kcal/100 g, respectively. Vitamin C was highest in the pulps (2.4 mg/g) than seed and peels (0.007 and 0.002 mg/g) respectively. The total sugar content of peels (59.7 mg/g) were more than the pulps and seeds (27.9 and 15.4 mg/g) respectively, sucrose was detected in seeds sample whilst not detected in peels and pulps. Total essential free amino acid (EFAA) concentrations of three samples were 36.5 g/100 g for peels, 33.7 g/100g for pulps and 25.2 g/100g for seeds sample. The total non-essential free amino acids in peels (31.6 g/100g) was higher than pulps and seeds (27.4 and 25.2 g/100 g) respectively.
Shifting transition states in the unfolding of a large ankyrin repeat protein

The 33-amino-acid ankyrin motif comprises a β-turn followed by two anti-parallel α-helices and a loop and tandem arrays of the motif pack in a linear fashion to produce elongated structures characterized by short-range interactions. In this article we use site-directed mutagenesis to investigate the kinetic unfolding mechanism of D34, a 426-residue, 12-ankyrin repeat fragment of the protein ankyrinR. The data are consistent with a model in which the N-terminal half of the protein unfolds first by unraveling progressively from the start of the polypeptide chain to form an intermediate; in the next step, the C-terminal half of the protein unfolds via two pathways whose transition states have either the early or the late C-terminal ankyrin repeats folded. We conclude that the two halves of the protein unfold by different mechanisms because the N-terminal moiety folds and unfolds in the context of a folded C-terminal moiety, which therefore acts as a “seed” and confers a unique directionality on the process, whereas the C-terminal moiety folds and unfolds in the context of an unfolded N-terminal moiety and therefore behaves like a single-domain ankyrin repeat protein, having a high degree of symmetry and consequently more than one unfolding pathway accessible to it.
Lactobacillus helveticus–fermented milk improves learning and memory in mice

Abstract Objectives To investigate the effects of Calpis sour milk whey, a Lactobacillus helveticus–fermented milk product, on learning and memory. Methods We evaluated improvement in scopolamine-induced memory impairment using the spontaneous alternation behaviour test, a measure of short-term memory. We also evaluated learning and working memory in mice using the novel object recognition test, which does not involve primary reinforcement (food or electric shocks). A total of 195 male ddY mice were used in the spontaneous alternation behaviour test and 60 in the novel object recognition test. Results Forced orally administered Calpis sour milk whey powder (200 and 2000 mg/kg) significantly improved scopolamine-induced cognitive impairments (P < 0.05 and P < 0.01, respectively) and object recognition memory (2000 mg/kg; P < 0.05). Discussion These results suggest that Calpis sour milk whey may be useful for the prevention of neurodegenerative disorders, such as Alzheimer's disease, and enhancing learning and memory in healthy human subjects; however, human clinical studies are necessary.
Development of STEADI

Falls among people aged ≥65 years are the leading cause of both injury deaths and emergency department visits for trauma. Research shows that many falls are preventable. In the clinical setting, an effective fall intervention involves assessing and addressing an individual’s fall risk factors. This individualized approach is recommended in the American and British Geriatrics Societies’ (AGS/BGS) practice guideline. This article describes the development of STEADI (Stopping Elderly Accidents, Deaths, and Injuries), a fall prevention tool kit that contains an array of health care provider resources for assessing and addressing fall risk in clinical settings. As researchers at the Centers for Disease Control and Prevention’s Injury Center, we reviewed relevant literature and conducted in-depth interviews with health care providers to determine current knowledge and practices related to older adult fall prevention. We developed draft resources based on the AGS/BGS guideline, incorporated provider input, and addressed identified knowledge and practice gaps. Draft resources were reviewed by six focus groups of health care providers and revised. The completed STEADI tool kit, Preventing Falls in Older Patients—A Provider Tool Kit, is designed to help health care providers incorporate fall risk assessment and individualized fall interventions into routine clinical practice and to link clinical care with community-based fall prevention programs.
Efficacy and Tolerability of Topiramate in Children Younger Than 2 Years Old

To evaluate the efficacy and tolerability of topiramate in children with epilepsy younger than 2 years of age, we retrospectively reviewed the records of patients treated at our institution between 2001 and 2003. Thirteen children ages 5 to 23 months, five boys and eight girls, were identified. Seizure types were partial (five), generalized tonic-clonic (three), myoclonic (one), and infantile spasms (four). The mean age at seizure onset was 9.7 months. Topiramate was started at a mean age of 11.4 months (4—23 months). The number of antiepileptic drugs prior to topiramate therapy ranged from zero to four. One patient had been on the ketogenic diet. Topiramate was used as monotherapy in seven children and as poly-therapy in six children. Mean follow-up was 14 months. The mean dose of topiramate was 8.8 mg/kg/day (2.5—18 mg/kg/day). The degree of seizure reduction was as follows: > 75% in five (38.5%) children, 50% to 75% in three (23%) children, and 0 to 25% in five (38.5%) children. Three of four (75%) patients with infantile spasms had a > 75% reduction in seizures. Adverse effects occurred in two children, including lethargy, hyperthermia, and anorexia. In children younger than 2 years of age, for whom the antiepileptic drug armamentarium is limited, topiramate appears to be an efficacious and safe therapeutic alternative for a variety of seizure types. (J Child Neurol 2005;20:667—670).
Genes in the Salmonella pathogenicity island 2 and the Salmonella virulence plasmid are essential for Salmonella‐induced apoptosis in intestinal epithelial cells

Intestinal epithelial cells are an important site of the host's interaction with enteroinvasive bacteria. Genes in the chromosomally encoded Salmonella pathogenicity island 2 (SPI 2) that encodes a type III secretion system and genes on the virulence plasmid pSDL2 of Salmonella enteritica serovar Dublin (spv genes) are thought to be important for Salmonella dublin survival in host cells. We hypothesized that genes in those loci may be important also for prolonged Salmonella growth and the induction of apoptosis induced by Salmonella in human intestinal epithelial cells. HT‐29 human intestinal epithelial cells were infected with wild‐type S. dublin or isogenic mutants deficient in the expression of spv genes or with SPI 2 locus mutations. Neither the spv nor the SPI 2 mutations affected bacterial entry into epithelial cells or intracellular proliferation of Salmonella during the initial 8 h after infection. However, at later periods, bacteria with mutations in the SPI 2 locus or in the spv locus compared to wild‐type bacteria, manifested a marked decrease in intracellular proliferation and a different distribution pattern of bacteria within infected cells. Epithelial cell apoptosis was markedly increased in response to infection with wild‐type, but not the mutant Salmonella. However, apoptosis of epithelial cells infected with wild‐type S. dublin was delayed for approximately 28 h after bacterial entry. Apoptosis was preceded by caspase 3 activation, which was also delayed for ∼ 24 h after infection. Despite its late onset, the cellular commitment to apoptosis was determined in the early period after infection as inhibition of bacterial protein synthesis during the first 6 h after epithelial cell infection with wild‐type S. dublin, but not at later times, inhibited the induction of apoptosis. These studies indicate that genes in the SPI 2 and the spv loci are crucial for prolonged bacterial growth in intestinal epithelial cells. In addition to their influence on intracellular proliferation of Salmonella, genes in those loci determine the ultimate fate of infected epithelial cells with respect to caspase 3 activation and undergoing death by apoptosis.
Lineage and genogroup-defining single nucleotide polymorphisms of Escherichia coli 2 O 157 : H 7 3 4

Corresponding author. Mailing address: Department of Veterinary Microbiology and Pathology, 17 Washington State University College of Veterinary Medicine, P. O. Box 647040, Pullman, WA 18 99164-7040. Phone: (509) 335-6075. Fax: (509) 335-8529. E-mail: tbesser@vetmed.wsu. edu. 19 AEM Accepts, published online ahead of print on 6 September 2013 Appl. Environ. Microbiol. doi:10.1128/AEM.02173-13 Copyright © 2013, American Society for Microbiology. All Rights Reserved.
Estradiol increases IRS-1 gene expression and insulin signaling in breast cancer cells.

This study demonstrates how the potentiating effects of E2 on insulin signaling in ER-positive breast cancer cells are consequent to an enhanced IRS-1 expression [corrected]. It induces an increase of both PI-3K/AKT and ERK1/2 activities. A direct action of E2 in the regulating mouse IRS-1 gene is also investigated in both Chinese hamster ovary and MCF-7 cells that are transfected with mouse IRS-1 regulatory sequences. The authors have reported, for the first time, how E2 induction of IRS-1 mRNA was correlated with a direct positive regulatory role of E2 on the IRS-1 promoter. This effect seems to be not strictly related to the cell type.
Applications of Satellite Imaging Radar

Significant developments have been made in space-based radar systems and technology since the first satellite with a radar payload was launched (the Gemini radar). This paper presents an overview of some of the remote sensing applications of satellite imaging radars, which range from topographic mapping to forest and climate monitoring to the detection of oil spills and the monitoring of natural disasters, to name just a few.
A 29 dBm 70.7% PAE Injection-Locked CMOS Power Amplifier for PWM Digitized Polar Transmitter

This letter presents an injection-locked CMOS power amplifier for pulse width modulation (PWM) digitized polar transmitter. A power oscillator combined with injection-locking technique reduces the required driving power and provide high drain efficiency in the power stage. The switched power oscillator is proposed for PWM digitized polar transmitter. To achieve differential to single output and impedance transformation, a lumped element balun, employing a minimum number of discrete components, is used. The power amplifier achieved a power-added efficiency of 70.7% at a maximum output power of 29.05 dBm. The measured drain efficiency in the power stage was 72.7% at 820 MHz. The chip is implemented with a 0.18 μm CMOS process. The total chip size is 0.48 mm2.
The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation*

The β subunit cytoplasmic domains of integrin adhesion receptors are necessary for the connection of these receptors to the actin cytoskeleton. The cytoplasmic protein, talin, binds to β integrin cytoplasmic tails and actin filaments, hence forming an integrin-cytoskeletal linkage. We used recombinant structural mimics of β1A, β1D and β3integrin cytoplasmic tails to characterize integrin-binding sites within talin. Here we report that an integrin-binding site is localized within the N-terminal talin head domain. The binding of the talin head domain to integrin β tails is specific in that it is abrogated by a single point mutation that disrupts integrin localization to talin-rich focal adhesions. Integrin-cytoskeletal interactions regulate integrin affinity for ligands (activation). Overexpression of a fragment of talin containing the head domain led to activation of integrin αIIbβ3; activation was dependent on the presence of both the talin head domain and the integrin β3 cytoplasmic tail. The head domain of talin thus binds to integrins to form a link to the actin cytoskeleton and can thus regulate integrin function.
Technical Note: The effect of 2D excitation profile on T1 measurement accuracy using the variable flip angle method with an average flip angle assumption

Purpose: To study the accuracy and precision of T1 estimates using the Variable Flip Angle (VFA) method in 2D and 3D acquisitions. Methods: Excitation profiles were simulated using numerical implementation of the Bloch equations for Hamming‐windowed sinc excitation pulses with different time‐bandwidth products (TBP) of 2, 6, and 10 and for T1 values of 295 ms and 1045 ms. Experimental data were collected in 5° increments from 5° to 90° for the same T1 and TBP values. T1 was calculated for every combination of flip angle with and without a correction for B1 and slice profile variation. Calculations were also made for flat slice profile such as obtained in 3D acquisition. Monte Carlo simulations were performed to obtain T1 measurement uncertainty. Results: VFA T1 measurements in 2D without correction can result in a 40–80% underestimation of true T1. Flip angle correction can reduce the underestimation, but results in accurate measurements of T1 only within a narrow band of flip angle combinations. The narrow band of accuracy increases with TBP, but remains too narrow for any practical range of T1 values or B1 variation. Simulated noisy VFA T1 measurements in 3D were accurate as long as the two angles chosen are on either side of the Ernst angle. Conclusions: Accurate T1 estimates from VFA 2D acquisitions are possible, but only a narrow range of T1 values within a narrow range of flip angle combinations can be accurately calculated using a 2D slice. Unless a better flip angle correction method is used, these results demonstrate that accurate measurements of T1 in 2D cannot be obtained robustly enough for practical use and are more likely obtained by a thin slab 3D VFA acquisition than from multiple‐slice 2D acquisitions. VFA T1 measurements in 3D are accurate for wide ranges of flip angle combinations and T1 values.
WHITE - DONKEY: Unmanned Aerial Vehicle for searching missing people

Searching for a missing person is not an easy task to accomplish,so over the years search methods have been developed, the problem is that the methods currently available have certain limitations and these limitations are reflected in time location. Time location in a person search is a very important factor that rescuers cannot afford to waste because the missing person is exposed to great dangers. In people search the vision system of the human being plays a very important role. The human visual system has the ability to detect and identify objects such as trees, walls, people among others besides to estimate the distance to them, this gives the human being the possibility of moving in their environment. With the development of artificial intelligence primarily to computer vision it is possible to model the human visual perception and generate computer software needed to simulate these capabilities. Using computer vision is expected to search for any missing person designing and implementing algorithms in order to an Unmanned Aerial Vehicle perform this task, also thanks to the speed of this is expected to reduce the time location. By using of a Unmanned Aerial Vehicle is not intended to replace the human being in the difficult task of searching and rescuing people but rather is intended to serve as a support tool in performing this difficult task.
Mechanism for Performing Label Switched Path Ping (LSP Ping) over MPLS Tunnels

This document describes methods for performing LSP ping (specified in RFC 4379) traceroute over MPLS tunnels and for traceroute of stitched MPLS Label Switched Paths (LSPs). The techniques outlined in RFC 4379 are insufficient to perform traceroute Forwarding Equivalency Class (FEC) validation and path discovery for an LSP that goes over other MPLS tunnels or for a stitched LSP. This document deprecates the Downstream Mapping TLV (defined in RFC 4379) in favor of a new TLV that, along with other procedures outlined in this document, can be used to trace such LSPs. [STANDARDS-TRACK]
Extended‐release but not immediate‐release and subcutaneous methylnaltrexone antagonizes the loperamide‐induced delay of whole‐gut transit time in healthy subjects

Methylnaltrexone (MNTX) is approved for subcutaneous treatment (MNTX‐SC) of opioid induced constipation. MNTX in oral immediate‐release (MNTX‐IR) and extended‐release (MNTX‐ER) dosage forms may antagonize the opioid induced delay in oro‐cecal transit time (OCT) as measured by using radiolabeled lactulose. Because lactulose acts laxative by its own and efficacy of MNTX on colon transit time (CTT) was unknown, the opioid antagonistic effects MNTX‐IR and MNTX‐ER (both 500 mg) relative to MNTX‐SC (12 mg) were evaluated in 15 healthy subjects with loperamide (LOP, 3 × 4 mg, 12 hourly) induced experimental constipation using the sulfasalazine/sulfapyridine method and radio‐opaque markers to measure OCT and whole gut transit time (WGT). MNTX‐ER significantly antagonized the LOP effects in 12 of our 15 subjects who responded to LOP with prolongation of WGT by 20.6–74.1 h (OCT by 0.50–10.5 h, CTT by 18.3–73.6 h). MNTX‐SC and MNTX‐IR were without significant influence. Compared to MNTX‐SC, bioavailability of MNTX‐IR and MNTX‐ER was 1.53–5.49 % and 0.11–1.24 %, respectively. MNTX‐SC and MNTX‐IR achieved active serum levels only for ∼3–5 h. MNTX‐ER antagonized the opioid‐induced delay of CTT most likely by local effects on µ‐opioid receptors in the colon.