Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy and Safety of Adjunctive Aripiprazole in Schizophrenia: Meta-Analysis of Randomized Controlled Trials

Abstract This meta-analysis of randomized controlled trials (RCTs) evaluated the efficacy and safety of adding aripiprazole to other antipsychotics in schizophrenia. A systematic computer search identified 55 RCTs including 4457 patients who were randomized to aripiprazole (14.0 ± 7.0 mg/d) versus placebo (18 RCTs) or open antipsychotic treatment (37 RCTs). Aripiprazole significantly outperformed the comparison interventions based on psychiatric scales: (1) total score in 43 RCTs (N = 3351) with a standardized mean difference (SMD) of −0.48 (95% confidence interval [CI], −0.68 to −0.28; P < 0.00001; I2 = 88%), (2) negative symptom score in 30 RCTs (N = 2294) with an SMD of −0.61(95% CI, −0.91 to −0.31; P < 0.00001; I2 = 91%), and (3) general psychopathology score in 13 RCTs (N = 1138) with a weighted mean difference (WMD) of −4.02 (95% CI, −7.23 to −0.81; P = 0.01; I2 = 99%), but not in positive symptoms in 29 RCTs (N = 2223) with a SMD of −0.01 (95% CI, 0.26 to 0.25; P = 0.95; I2 = 88%). Differences in total score based on psychiatric scales may be explained by the use of an antipsychotic for comparison rather than placebo in 31 RCTs with a nonblind design. Aripiprazole outperformed the comparison interventions for body weight in 9 RCTs (N = 505) with a WMD of −5.08 kg (95% CI, −7.14 to −3.02; P < 0.00001; I2 = 35%) and for body mass index (BMI) in 14 RCTs (N = 809) with a WMD of −1.78 (CI: −2.25 to −1.31; P < 0.00001; I2 = 54%). The BMI meta-regression analysis indicated aripiprazole's association with lower BMI was stronger in females. Adjunctive aripiprazole appears safe but better RCTs are needed to demonstrate efficacy. Chinese journals and scientific societies should encourage the publication of high-quality RCTs and require registration in a centralized Chinese database.
Xanthonectria , a new genus for the nectrioid fungus Nectria pseudopeziza

Ascomycete.org, 8 (4) : 172-178. Juillet 2016 Mise en ligne le 08/07/2016 Abstract: A new genus, Xanthonectria, is proposed for the enigmatic taxon Nectria pseudopeziza. Xanthonectria is characterized by nonstromatic, soft-textured, superficial, glabrous, pale yellow to bright orange nectria-like ascomata, not changing colour in 3% KOH or lactic acid, long fusiform, multiseptate ascospores and an acremonium-like asexual morph. Its placement in the Bionectriaceae and its relationship to other members of this family are based on morphological, cultural and molecular data.
Oscillation mode linewidths of solar-type stars observed by Kepler

Context. Solar-like oscillations have been observed by Kepler and CoRoT in several solar-type stars. Aims. We study the variations of stellar mode linewidth as a function of effective temperature. Methods. Time series of 9 months of data have been used. The power spectra of 42 solar-type stars have been analysed using both Maximum Likelihood Estimators and Bayesian estimators, providing individual mode characteristics such as frequencies, linewidths and mode heights. Results. Here we report on the mode linewidth at maximum power and at maximum mode height for these 42 stars as a function of effective temperature. Conclusions. We show using 9 months of Kepler observations of 42 stars that the mode linewidth at either maximum mode height or maximum amplitude follows a scaling relation, which is a combination of a power law plus a lower bound. The typical power law index is about 13 for the linewidth derived from the maximum mode height, and about 16 for the linewidth derived from the maximum amplitude while the lower bound is about 0.3 μHz and 0.7 μHz, respectively. We stress that this scaling relation is only valid for solar-type stars, and does not have predictive power outside the temperature range of these stars.
RECOVERY OF PALM KERNEL OIL FROM PALM KERNEL CAKE USING SUPERCRITICAL CARBON DIOXIDE AND THE SOLUBILITY EXAMINATION

In this work, application of SC-CO2 to extract palm kernel oil from palm kernel cake was performed. The extraction and solubility examination were performed in the temperature and pressure ranges of 40 to 80 oC and 3000 to 5000 psi respectively. The oil trapped in the sample cake was about 14.25% (dry basis) and it can be recovered by using SC-CO2 extraction process. The extraction yield was about more than 95% in every condition. The extraction yield could approach 100% when the preesure condition was 5000 psi. The equilibrium solubility of the PKO in SC-CO2 has been examined using of extraction curve analysis. It was obtained that the experimental solubility were from 0.015 to 0.0503 g oil/g CO2 depend on the extraction condition.
On Relativistic Interactions in Quantum Theories

This thesis is dedicated to the question: (How) Is a relativistic quantum theory with interaction possible? We discuss the problems of quantum field theories, especially the non-existence of dynamics, which lead us to consider alternative approaches. Multi-time wave functions are identified as the basic objects in relativistic quantum mechanics. Focusing on models with constant particle number, we present several possibilities how interaction can be achieved. We give an overview of the current state of research concerning relativistic quantum theory, followed by a number of own contributions. For one method of implementing interaction, namely by boundary conditions, we present a model of N identical mass-less particles moving in one dimension. The multi-time wave function satisfies a system of N Dirac equations with boundary conditions on the space-time configurations where two particles meet, which leads to a relativistic contact interaction. Lorentz invariance as well as probability conservation are proven rigorously and the unique solution of this model is obtained by a generalized method of characteristics. The effective potential, which features δ-functions of the particle distances, is derived by self-adjoint extensions of the Dirac Hamiltonian for several particles. Another promising way of generating interaction is the use of integral equations. As an example, we consider the Bethe-Salpeter equation, a multi-time integral equation supposed to describe bound states in quantum electrodynamics. Problems connected with this equation such as the lacking gauge invariance and the “abnormal solutions” are explained and some ideas to resolve them are mentioned. Lastly, we perform the non-relativistic limit of the Bethe-Salpeter equation in position space and thereby derive the Breit equation in a new way.
A Wearable System That Captures Human Activities and Social Interactions

This paper describes a wearable system for detecting, recognizing and recording what a user sees, says, and does. The developed system is a core component of our project of building a machine-readable interaction corpus, with stationary sensing systems installed ubiquitously in an indoor environment. The system is composed of a mobile PC, a camera, a microphone, and two microcontroller-based sensing modules. One of the modules is for recognizing the motion of a user such as sitting, standing, walking, and ascending/descending a stairway. The other has a CMOS image sensor to detect and recognize the ID tags with infrared LED, which are attached to other people, artifacts, and some places. Using the camera and microphone, the mobile PC collects the video/audio data as well as the recognized information about current motion, location, people and/or artifacts.
99mTc-Annexin-V Functional Imaging of Luminal Thrombus Activity in Abdominal Aortic Aneurysms

Background—The mural thrombus of abdominal aortic aneurysms (AAA) is involved in aneurysm progression via several interdependent biological processes including platelet activation. 99mTc-annexin V (ANX) is a scintigraphic tracer that binds to phosphatidylserine exposed on activated platelets and apoptotic cells. Here, we evaluated the potential of ANX imaging to assess mural thrombus biological activity in an experimental AAA model. The clinical applicability was further tested ex vivo on human samples of excised AAA thrombi. Methods and Results—Experimental AAA was created by infusing elastase into infrarenal abdominal aorta in 17 rats, and 6 sham-operated rats were used as controls. Abdominal ANX scintigraphy was performed 2 weeks later followed by quantitative autoradiography and histological studies. Among the 13 rats which developed AAA, 11 displayed intense ANX uptake within AAA by scintigraphy. ANX uptake in the aneurysms on planar and single-photon emission computed tomography (SPECT) imaging was higher than that observed in infrarenal aorta of sham-operated controls (target/background ratio: 5.7±0.9 versus 1.33±0.21; P<0.005 for SPECT). Aneurysm-to-background activity ratios obtained by scintigraphy correlated with ANX activity in corresponding autoradiograms (R=0.69; P<0.02). This activity was located in the thrombus area where activated platelets and polymorphonuclear leukocytes accumulated. Similar patterns were also found in all of the 7 human AAA thrombi harvested during surgery. Conclusions—ANX imaging may assess mural thrombus renewal activity linked to permanent flowing blood interface.
Interaction of sertraline with clozapine.

Editors:The selective serotonin reuptake inhibitors have an inhibitory effect on several P450 cytochrome isoenzymes. Fluoxetine and paroxetine are powerful inhibitors of CYP2D6, which is involved in the metabolism of most neuroleptics and antidepressants. Clozapine is not metabolized by CYP2D6. [1]
Symptom Response and Healing of Erosive Esophagitis with Proton-Pump Inhibitors in Patients with Helicobacter pylori Infection

OBJECTIVES:The aim of this article is to determine the severity of esophagitis and the response to treatment with proton-pump inhibitors in patients with and without evidence of Helicobacter pylori infection.METHODS:This retrospective analysis evaluated data collected in a randomized, double-blind clinical trial that assessed the efficacy and safety of once-daily esomeprazole 40 mg (n = 2,624) versus lansoprazole 30 mg (n = 2,617) for up to 8 wk in the treatment of reflux-associated erosive esophagitis. At baseline, erosive esophagitis was graded using the Los Angeles (LA) classification; serologic testing for H. pylori was performed using a FlexSure HP® serum test.RESULTS:There were 14.7% of patients who were seropositive for H. pylori. The percentages of seropositive and seronegative patients with each grade of esophagitis were: LA grade A, 38%, 36%; LA grade B, 41%, 39%; LA grade C, 16%, 19%; and LA grade D, 5%, 6%, respectively. Severe heartburn was present at baseline in 42% of H. pylori-positive and 42% of H. pylori-negative patients. Life-table healing rates with esomeprazole were not influenced by H. pylori status (seropositive 92.6% (95% confidence interval: 89.8–95.4); seronegative 92.6% (95% confidence interval: 91.4–93.7)). The rates with esomeprazole were significantly higher than those with lansoprazole (seropositive 90.5% (95% confidence interval: 87.5–93.5); seronegative 88.5% (95% confidence interval: 87.1–89.8)) after adjusting for baseline H. pylori status (p = 0.001). CONCLUSIONS:The severity of erosive esophagitis at baseline was similar regardless of H. pylori seropositivity. Healing rates were not influenced by H. pylori status.
HELMETS , INGOTS AND IDOLS : AN UPDATE ON THE HALLATON FINDS

The hilltop shrine and associated special deposits of metalwork and animal bones from Hallaton, Leicestershire, dating to around the time of the Roman invasion in AD 43, has altered our perception and understanding of the complex social dynamics of the peoples of the East Midlands before, during and just after the Roman conquest. This paper outlines the results of the analysis and publication of some of the key artefacts from the site and discusses some of the theories behind their deposition on a Leicestershire hilltop.
SCIENCE AND ART: A FUTURE FOR STONE

Mokattam limestone is the most frequent building stone used in the cultural heritage buildings in Historic Cairo (Egypt) and it is susceptible to the ongoing effects of salt weathering. A purpose-made simulation chamber was used to test in the laboratory the salt weathering on limestone samples from an active quarry at Helwan area (30 km, south Cairo) at different temperature regimes (20, 30 and 40°C). To assess the extent of the resulted decay, mechanical properties of the fresh quarry and tested samples after different regimes were investigated with non-destructive techniques (P-wave velocity and Leeb rebound hardness) and destructive techniques (uniaxial compression strength). The different mechanical measurements of the tested samples were notably affected after the different temperature regimes. Uniaxial compressive strength is highly correlated with Leeb rebound hardness while P-wave velocity showed a low relevance for the prediction of the strength of the tested samples.
The Expression, Functions, Interactions and Prognostic Values of PTPRZ1: A Review and Bioinformatic Analysis

Available studies demonstrate that receptor-type tyrosine-protein phosphatase zeta (PTPRZ1) is expressed in different tumor tissues, and functions in cell proliferation, cell adhesion and migration, epithelial-to-mesenchymal transition, cancer stem cells and treatment resistance by interacting with or binding to several molecules. These included pleiotrophin (PTN), midkine, interleukin-34, β-catenin, VEGF, NF-κB, HIF-2, PSD-95, MAGI-3, contactin and ErbB4. PTPRZ1 was involved in survival signaling and could predict the prognosis of several tumors. This review discusses: the current knowledge about PTPRZ1, its expression, co-receptors, ligands, functions, signaling pathway, prognostic values and therapeutic agents that target PTPRZ1.
Self-efficacy and depression among low vision seniors

Previous research has indicated that depression is associated with visual impairment, especially in the elderly population. This relationship may, in part, be explained by a loss of independence as well as functional disability experienced by seniors in everyday activities as compared to people with normal vision. However, research has not investigated the possible mediating role of self-efficacy, a term describing individuals’ sense of their abilities and capacities to deal with conditions that life puts before them. The objective of the present study was to examine whether seniors with low vision who are depressed also display lower levels of self-efficacy. It was hypothesized that a person’s total score on the General Self-Efficacy Scale would remain a statistically significant predictor of his/her total score on the Center for Epidemiologic Studies – Depression Scale, after accounting for the effects of age and visual acuity. The acuity of each participant was evaluated using the Early Treatment of Diabetic Retinopathy Study (ETDRS) acuity chart. The two questionnaires were administered verbally and the participants were required to be fluent in French and have adequate hearing. Data were collected on 64 participants, ranging in age from 64 to 96 years and ranging in acuity from 20/70 worse to 20/900 or worse in their better eye. Given that patients with Low Vision are at a significant risk of developing depression, understanding underlying predispositions would be very helpful to rehabilitation specialists. This approach could alleviate some of the burden on the rehabilitation service providers by prioritizing clients with specific needs.
ASSOCIATION BETWEEN EARLY-ONSET PARKINSON ’ S DISEASE AND MUTATIONS IN THE PARKIN GENE

C HRISTOPH B. L ÜCKING , M.D., A LEXANDRA D ÜRR , M.D., P H . D. , V INCENZO B ONIFATI , M.D., J ENNY V AUGHAN , M.D., G IUSEPPE D E M ICHELE , M.D., T HOMAS G ASSER , M.D., B ISWADJIET S. H ARHANGI , M.D., G IUSEPPE M ECO , M.D., P ATRICE D ENÈFLE , P H . D. , N ICHOLAS W. W OOD , M.D., P H . D. , Y VES A GID , M.D., P H . D. , AND A LEXIS B RICE , M.D., FOR THE E UROPEAN C ONSORTIUM ON G ENETIC S USCEPTIBILITY IN P ARKINSON ’ S D ISEASE
Pioglitazone and Rosiglitazone Decrease Prostaglandin E2 in Non–Small-Cell Lung Cancer Cells by Up-Regulating 15-Hydroxyprostaglandin Dehydrogenase

Lung cancer cells elaborate the immunosuppressive and antiapoptotic mediator prostaglandin E2 (PGE2), a product of cyclooxygenase-2 (COX-2) enzyme activity. Because peroxisome proliferator-activated receptor (PPAR)γ ligands, such as thiazolidinediones (TZDs), inhibit lung cancer cell growth, we examined the effect of the TZDs pioglitazone and rosiglitazone on PGE2 levels in non–small-cell lung cancer (NSCLC) A427 and A549 cells. Both TZDs inhibited PGE2 production in NSCLC cells via a COX-2 independent pathway. To define the mechanism underlying COX-2 independent suppression of PGE2 production, we focused on other enzymes responsible for the synthesis and degradation of PGE2. The expression of none of the three prostaglandin synthases (microsomal PGES1, PGES2 and cystosolic PGES) was down-regulated by the TZDs. It is noteworthy that 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an enzyme that produces biologically inactive 15-ketoprostaglandins from active PGE2, was induced by TZDs. The TZD-mediated suppression of PGE2 concentration was significantly inhibited by small interfering RNA to 15-PGDH. Studies using dominant-negative PPARγ overexpression or 2-chloro-5-nitrobenzanilide (GW9662; a PPARγ antagonist) revealed that the suppressive effect of the TZDs on PGE2 is PPARγ-independent. Together, these findings indicate that it is possible to use a clinically available pharmacological intervention to suppress tumor-derived PGE2 by enhancing catabolism rather than blocking synthesis.
EURASIAN JOURNAL OF BUSINESS AND MANAGEMENT

This study addresses how different styles of humor affect creativity and how innovation climate at the universities moderates this relationship. Questionnaire data were collected from 362 academics from various public and private universities in Turkey. Correlation, an exploratory factor analysis (EFA) and a confirmatory factor analysis (CFA) utilizing structural equation modelling and hierarchical regression analysis were used to test the hypotheses. As suggested in the hypotheses, it is found out that while self-enhancing and affiliative humor are positively related to academics’ creativity, aggressive humor is negatively related to academics’ creativity. However, self-defeating humor is not significantly related to creativity as argued and innovation climate partially moderates the relationship between humor styles and creativity. The findings suggest important managerial implications on how to make use of humor styles to boost creativity and overall organizational effectiveness.
3 D FEATURE DESCRIPTORS AND IMAGE RECONSTRUCTION TECHNIQUES : A REVIEW

The image reconstruction is being widely used in many medical and engineering applications because of the low cost 3D scanners. 3D feature descriptor play a major role in image reconstruction. The Objective of this paper is to compare different 3D feature descriptors and image reconstruction techniques. 3D image reconstruction techniques reconstruct 3D shapes from images captured using depth sensor and label the object, based on the reconstructed 3D shapes. From the set of images 3D models are created, refers to 3D reconstruction. Normally, 3D scenes are captured to get 2D images which is the reverse processes of 3D reconstruction. This paper gives review about different feature descriptors and techniques used for 3D image reconstruction.
One-toone demand forecasting model and its application for inventory management

In this study, we propose a demand forecasting model for inventory management and apply it to low-involvement and repeat-purchase products, particularly to households’ demand for alcoholic beverages. We constructed a model involving household heterogeneity, commonality and time-trend effects. The results revealed that the proposed model maintained a high forecasting performance for long periods. This model can estimate household-level demand and potential tendencies of product consumption. We also discuss the wide range of applications of the model. Key word: Inventory Management, Marketing Demand Forecasting Model
Superior Visual Search in Adults with Autism

Recent studies have suggested that children with autism perform better than matched controls on visual search tasks and that this stems from a superior visual discrimination ability. This study assessed whether these findings generalize from children to adults with autism. Experiments 1 and 2 showed that, like children, adults with autism were superior to controls at searching for targets. Experiment 3 showed that increases in target-distractor similarity slowed the visual search performance of the control group significantly more than that of the autism group, suggesting that the adults with autism have a superior visual discrimination ability. Thus, these experiments replicate in adults previous findings in children with autism. Superior unique item detection in adults with autism, stemming from enhanced discrimination, is discussed in the light of the possible role of stimulus processing disturbances in the disorder in general.
5-15-2019 EXPLAINING CUSTOMER ACTIVATION WITH DEEP ATTENTION MODELS

Effectively informing consumers is a big challenge for financial service providers. Triggering involvement in the personal situation of the client is a result of sending relevant information at the right time. While general machine learning techniques are able to accurately predict the behavior of consumers, they tend to lack interpretability. This is a problem since interpretation aims at producing the information a communication department requires to be able to trigger involvement. In this paper we provide a solution for predicting and explaining customer activation as result of a series of events, by means of deep learning and attention models. The proposed solution is applied to data concerning the activity of pension fund participants and compared to standard machine learning techniques on both accuracy and interpretability. We conclude that the attention based model is as accurate as top tier machine learning algorithms in predicting customer activation, while being able to extract the key events in the communication with a single customer. This results in the ability to help understand the needs of customers on a personal level and to construct an individual marketing strategy for each customer.
Digitally Fabricating Tilted Holes: Experiences in Tooling and Teaching Design

Digital fabrication of building components by means of computer numerically controlled (CNC) machines is of high interest for architects and the building industry. Common design software does not allow for utilizing the potential that lies within these new technologies. To fully exploit the power of digital fabrication, new design paradigms have to be explored. In our design studios we implement direct scripting, the use of images to control parameters, as well as dynamical and rule based systems, which enables the designer to exploit the possibilities of digital fabrication. This paper provides an overview of the tools we developed. We will present some of the results from these classes and discuss its implications for future tool sets. It is essential to apply the knowledge of production methods at the starting point of the design process, in order to fully benefit from these new technologies. We believe that novel design strategies emerge out of this shift in production. Our goal is to integrate the principles of digital fabrication into the design process, resulting in a more valuable and sustainable architecture.