Miracle-dz/UniFAR-FTUs huggingface dataset:
Performance approximation of pick-to-belt orderpicking systems

In this paper, an approximation method is discussed for the analysis of pick-to-belt orderpicking systems. The aim of the approximation method is to provide an instrument for obtaining rapid insight in the performance of designs of pick-to-belt orderpicking systems. It can be used to evaluate the effects of changing the layout of the system, the number of picking stations, the number of pickers, the conveyor speed, the number of bins to be processed per day, the number of orderlines per bin, etc. Especially in the design phase, modeling and analysis speed is more important than accuracy. The method presented in this paper is based on Jackson network modeling and analysis. The method is fast and sufficiently accurate. The method is used by Ingenieursbureau Groenewout B.V. , for early-stage evaluation of design alternatives of pick-to-belt orderpicking systems and general transportation systems.
Correlation between Blood Activin Levels and Clinical Parameters of Type 2

Aims. Activins A and B, and their binding protein, follistatin, regulate glucose metabolism and inflammation. Consequently, their role in type 2 diabetes (T2D) was examined. Methods. Blood was taken from fasted participants (34 males; 58 females; 50–75 years) with diabetes or during an oral glucose tolerance test (OGTT). Clinical parameters were assessed, and blood assayed for activins, follistatin, and C-reactive protein. Results. Serum levels of activin A (93.3 ± 27.0 pg/mL, mean ± SD), B (81.8 ± 30.8 pg/mL), or follistatin (6.52 ± 3.15 ng/mL) were not different (P > 0.05) between subjects with normal OGTT (n = 39), impaired glucose tolerance and/or fasting glucose (n = 17), or T2D (n = 36). However, activin A and/or activin B were positively correlated with parameters of insulin resistance and T2D, including fasting glucose (P < 0.001), fasting insulin (P = 0.02), glycated hemoglobin (P = 0.003), and homeostasis model assessment of insulin resistance (HOMA-IR; P < 0.001). Follistatin was positively correlated with HOMA-IR alone (P = 0.01). Conclusions. These data indicate that serum measurements of activin A, B, or follistatin cannot discriminate risk for T2D in individual patients, but the activins display a positive relationship with clinical parameters of the disease.
Application of Student's t-test, Analysis of Variance, and Covariance

Student's t test (t test), analysis of variance (ANOVA), and analysis of covariance (ANCOVA) are statistical methods used in the testing of hypothesis for comparison of means between the groups. The Student's t test is used to compare the means between two groups, whereas ANOVA is used to compare the means among three or more groups. In ANOVA, first gets a common P value. A significant P value of the ANOVA test indicates for at least one pair, between which the mean difference was statistically significant. To identify that significant pair(s), we use multiple comparisons. In ANOVA, when using one categorical independent variable, it is called one-way ANOVA, whereas for two categorical independent variables, it is called two-way ANOVA. When using at least one covariate to adjust with dependent variable, ANOVA becomes ANCOVA. When the size of the sample is small, mean is very much affected by the outliers, so it is necessary to keep sufficient sample size while using these methods.
Estimating spot volatility with high-frequency financial data

We construct a spot volatility estimator for high-frequency financial data which contain market microstructure noise. We prove consistency and derive the asymptotic distribution of the estimator. A data-driven method is proposed to select the scale parameter and the bandwidth parameter in the estimator. In Monte Carlo simulations, we compare the finite sample performance of our estimator with some existing estimators. Empirical examples are given to illustrate the potential applications of the estimator. JEL Classification: C58, C13, C14.
NUMBER ? ? ? JANUARY 2009 1 – 10 apertium-cya collaboratively-developed free RBMT system for Welsh to English

apertium-cy (http://www.cymraeg.org.uk) is a rule-based “gisting” machine translation system for Welsh to English, with both engine and data released under the GPL. We summarise the development of apertium-cy, evaluate its output, and discuss the advantages of a collaborative development model combined with rule-based MT for marginalised languages. 1. The Apertium platform apertium-cy is a “gisting” machine translation system for Welsh to English, based on the Apertium machine translation platform.1 The platform was originally aimed at the Romance languages of the Iberian peninsula, but is now being adapted for other languages (such as Basque, and languages from the Celtic group –Welsh, Irish, Breton), with much of the work on new languages being pursued by volunteers, following the increasingly common collaborative development model used for free2 and open-source software. Apertium is licensed under the Free Software Foundation’s GNU General Public License,3 and all the software and data for the 17 supported language pairs (and the other pairs in development) is available for download from the project website. Apertium follows a shallow-transfer approach, and is very fast. Finite-state transducers (Garrido-Garrido-Alenda and Forcada, 2002, Roche and Schabes, 1997) processing up to 40,000 words per second are used for lexical processing, first-order hidden Markov models (HMM) are used for part-of-speech tagging, and multi-stage finite-state based chunking for structural transfer. 1http://www.apertium. org 2We follow the definition of “free” used by the Free Software Foundation http://www.fsf. org. 3http://www.fsf. org/licensing/licenses/gpl.html, accessed 12/12/2008. © 2009 PBML. All rights reserved. Please cite this article as: Francis Tyers, Kevin Donnelly, apertium-cy a collaboratively-developed free RBMT system for Welsh to English. The Prague Bulletin of Mathematical Linguistics No. ? , 2009, 1–10. PBML ? JANUARY 2009 The software behind the platform is implemented as a standard UNIX pipeline, with each stage in the translation having a separate C++ program. Communication between each stage uses piped text streams. XML-based formats are used to encode the linguistic data, which are then compiled into the high-speed formats used by the engine. Further details are given in (Armentano-Armentano-Oller et al., 2006), and on the project website.
Central Venous Pressure (CVP) Reduction Associated With Higher Cardiac Output (CO) Favors Good Prognosis of Circulatory Shock: A Single-Center, Retrospective Cohort Study

Background: The Frank-Starling curve is the basis of hemodynamics. Changes in cardiac output (CO) caused by central venous pressure (CVP) are the most important concerns in the treatment of critically ill patients. Objectives: To explore the use of CVP and its relevant mechanisms with respect to CO in the clinic. Methods: A total of 134 patients with circulatory shock were retrospectively included and analyzed. Hemodynamic data were recorded and analyzed at PICCO initiation and 24 h after PICCO. Data regarding 28-day mortality and renal function were also collected. Results: The patients were divided into a CVP↑+ CO↑ group (n = 23), a CVP↑+ CO↓ group (n = 29), a CVP↓+ CO↑ group (n = 44), and a CVP↓+ CO↓ group (n = 38) based on values at PICCO initiation and 24 h after PICCO. Post- hoc tests showed that the CVP↓+ CO↑ group had a higher 28-day survival than the other groups [log-rank (Mantel-Cox) = 8.758, 95%, CI, 20.112–23.499, P = 0.033]. In terms of hemodynamic characteristics, the CVP↓+ CO↑ group had a lower cardiac function index (CFI) (4.1 ± 1.4/min) and higher extravascular lung water index (EVLWI) (11.0 ± 4.7 ml/kg) at PICCO initiation. This group used more cardiotonic drugs (77.3%, P < 0.001) and had a negative fluid balance (−780.4 ± 1720.6 ml/24 h, P = 0.018) 24 h after PICCO than the other three groups. Cardiotonic drug use and dehydration treatment were associated with increased CFI (from 4.1 ± 1.4 /min to 4.5 ± 1.3/min, P = 0.07) and reduced ELVWI (from 11.0 ± 4.7 ml/kg to 9.0 ± 3.5 ml/kg, P = 0.029). Renal function tests showed that SCr and BUN levels in the CVP↓+ CO↑ group were significantly improved (SCr from 197.1 ± 128.9 mmol/L to 154.4 ± 90.8 mmol/L; BUN from 14.3 μmol/L ± 7.3 to 11.6 ± 7.0 μmol/L, P < 0.05). Conclusions: Lower CVP was associated with increased CO, which may improve the 28-day prognosis in patients with circulatory shock. Notably, higher CO derived from lower CVP may also contribute to renal function improvement.
Adherence to isoniazid preventive therapy for tuberculosis among HIV patients in Kano, Nigeria

Background: Tuberculosis (TB) is the most common opportunistic infection among human immunodeficiency virus (HIV)-infected individuals. It is a major cause of mortality among patients with HIV and poses a risk throughout the course of HIV disease. Adherence to isoniazid preventive therapy (IPT) is a critical factor that needs to be considered in scaling up services in developing countries. Objectives: The study aimed to assess adherence and associated factors to IPT among HIV patients in Kano. Methods: Using a cross-sectional study design, interviewer-administered questionnaire was used to collect information from 320 HIV patients from two comprehensive health centers (CHCs). Results: Up to two-third, 211 (65.9%) of the participants were aware of the use of isoniazid for the prevention of TB among HIV/AIDS patients, but only about half 172 (53.8%) of the respondents interviewed were currently using IPT for TB prevention. Up to 158 (89.5%) of the 172 respondents interviewed had good level of adherence to IPT and the main reasons to enhance adherence were disclosure of HIV status to partner/relatives (77.9%), adequate counseling about IPT (62.8%), and awareness of IPT for TB prevention (65.9%). Conclusion: Good level of adherence to IPT from this study implies that the need for improve strategies to ensure IPT scale up as adherence to IPT among HIV clients in Kano is optimal, but uptake remains low.
Exposure of Aspergillus flavus NRRL 3357 to the Environmental Toxin, 2,3,7,8-Tetrachlorinated Dibenzo-p-Dioxin, Results in a Hyper Aflatoxicogenic Phenotype: A Possible Role for Caleosin/Peroxygenase (AfPXG)

Aflatoxins (AFs) as potent food contaminants are highly detrimental to human and animal health. The production of such biological toxins is influenced by environmental factors including pollutants, such as dioxins. Here, we report the biological feedback of an active AF-producer strain of A. flavus upon in vitro exposure to the most toxic congener of dioxins, the 2,3,7,8-tetrachlorinated dibenzo-p-dioxin (TCDD). The phenotype of TCDD-exposed A. flavus was typified by a severe limitation in vegetative growth, activation of conidia formation and a significant boost in AF production. Furthermore, the level of reactive oxygen species (ROS) in fungal protoplast was increased (3.1- to 3.8-fold) in response to TCDD exposure at 10 and 50 ng mL–1, respectively. In parallel, superoxide dismutase (SOD) and catalase (CAT) activities were, respectively, increased by a factor of 2 and 3. In contrast to controls, transcript, protein and enzymatic activity of caleosin/peroxygenase (AfPXG) was also significantly induced in TCDD-exposed fungi. Subsequently, fungal cells accumulated fivefold more lipid droplets (LDs) than controls. Moreover, the TCDD-exposed fungi exhibited twofold higher levels of AFB1. Interestingly, TCDD-induced hyperaflatoxicogenicity was drastically abolished in the AfPXG-silencing strain of A. flavus, suggesting a role for AfPXG in fungal response to TCDD. Finally, TCDD-exposed fungi showed an increased in vitro virulence in terms of sporulation and AF production. The data highlight the possible effects of dioxin on aflatoxicogenicity of A. flavus and suggest therefore that attention should be paid in particular to the potential consequences of climate change on global food safety.
Skeletal Muscle Depletion Predicts the Prognosis of Patients With Hepatocellular Carcinoma Treated With Radiotherapy

Background: Sarcopenia is gaining attention as a poor prognostic factor for various types of malignancies. This study evaluated the prevalence and prognostic significance of sarcopenia and its association with survival in hepatocellular carcinoma (HCC) patients who underwent radiotherapy (RT) to the primary site. Materials and Methods: Between January 2009 and November 2016, 156 patients with HCC that underwent RT to the liver were retrospectively studied. Sarcopenia was defined as an L3 skeletal muscle index of <49 cm2/m2 for men and <41 cm2/m2 for women as proposed by Korean-specific cut-off value. Sarcopenia was identified pre- and post-RT (within 3 months from the end of RT). Results: Pre-RT sarcopenia occurred in 99 (63.5%) patients and was significantly associated with higher levels of protein induced by vitamin K absence or antagonist-II (PIVKA-II), lower percentage of overweight/obesity (body-mass index), higher percentage of previous systemic chemotherapy, and lower total RT dose. At a median follow-up of 9.3 months, median overall survival (OS) was significantly lower in patients with pre-RT sarcopenia than in those without (7.1 vs. 15.3 months, p < 0.001). In multivariate analysis [reporting hazard ratio (HR): 95% confidence interval (CI)], albumin-bilirubin score (2.35: 1.33–4.17; p = 0.003), total dose (0.44: 0.27–0.71; p = 0.001), and pre-RT sarcopenia (2.38: 1.53–3.70; p < 0.001) were independent OS prognostic factors. Among patients without pre-RT sarcopenia, 20 newly developed sarcopenia after RT and showed significantly lower OS compared to those without sarcopenia after RT (n = 35) (median 14.1 vs. 17.5 months, p = 0.018). Multivariate logistic regression analysis [reporting odds ratio (OR)] demonstrated older age (310.190; p = 0.007), Child-Pugh classification B or C (15.239; p = 0.047), higher alpha-fetoprotein (128.486; p = 0.008), higher PIVKA-II (118.536; p = 0.027), and larger planning target volume (51.310; p = 0.026) as significant factors for newly developed post-RT sarcopenia. Conclusion: Newly developed sarcopenia after RT, as well as pre-RT sarcopenia, were associated with poor survival for HCC patients who underwent RT to the liver. This result suggests the possibility that early intervention such as nutritional support and exercise therapies before and during RT could prevent muscle wasting and may be effective in improving the prognosis of HCC patients.
Ju l 2 01 5 Locally Non-linear Embeddings for Extreme Multi-label Learning

The objective in extreme multi-label learning is to train a c l ssifier that can automatically tag a novel data point with the most relevant subsetof labels from an extremely large label set. Embedding based pproaches make training and prediction tractable by assuming that the training labe l matrix is low-rank and hence the effective number of labels can be reduced by projecting the high dimensional lab el vectors onto a low dimensional linear subspace. Still, leading embedding approaches have been unable to deliver hi gh prediction accuracies or scale to large problems as the low rank assumption is violated in most real world applic ations. This paper develops the X1 classifier to address both limitat ions. The main technical contribution in X1 is a formulation for learning a small ensemble of local distance pr serving embeddings which can accurately predict infrequently occurring (tail) labels. This allows X1 to bre ak free of the traditional low-rank assumption and boost classification accuracy by learning embeddings which prese rv pairwise distances between only the nearest label vectors. We conducted extensive experiments on several real-world a s well as benchmark data sets and compared our method against state-of-the-art methods for extreme multi -label classification. Experiments reveal that X1 can make significantly more accurate predictions then the state-ofthe-art methods including both embeddings (by as much as 35%) as well as trees (by as much as 6%). X1 can also scale effici ently to data sets with a million labels which are beyond the pale of leading embedding methods.
White Matter Integrity Is Associated With Intraindividual Variability in Neuropsychological Test Performance in Healthy Older Adults

Inconsistency of performance across neuropsychological testing instruments (dispersion) shows sensitivity to acquired injury and neurodegenerative pathology in older adults. The underlying neural correlates have remained speculative however, in spite of known white matter degradation seen in conjunction with elevated inconsistency in related operationalizations of intraindividual variability. Consistently, these operationalizations have controlled for artifactual age-related variance to increase measurement sensitivity of CNS dysfunction. In this study, dispersion was examined alongside composite scores of memory and executive functioning from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Forty-four healthy older adults (M = 72.0, SD = 6.4) underwent Diffusion Tensor Imaging (DTI) and neuropsychological testing spanning a range of cognitive domains. The results replicated previous findings, demonstrating reduced microstructural integrity with advanced age and increased integrity in high memory and executive functioning performers, across all major white matter tracts. With age first regressed from the composite scores, significant associations remained between greater executive functioning scores and greater microstructural integrity in the genu of the corpus callosum, right anterior corona radiata, anterior, posterior and rentrolenticular parts of right internal capsule, as well as right posterior thalamic radiation. With age regressed from the dispersion scores, greater values were primarily associated with decreased white matter integrity in the body and genu of corpus callosum, anterior corona radiata bilaterally and left superior longitudinal fasciculus. Dispersion is easily computed across speeded and accuracy-based measures and shows promise in detecting white matter damage, beyond that seen in the typical aging process. This appears to be the first investigation of neural correlates associated with increased dispersion.
Editorial: New Insights on Neuron and Astrocyte Function From Cutting-Edge Optical Techniques

Department of Neuroscience, Institute for Systems Genomics, Stem Cell Institute, UConn Health, Farmington, CT, United States, 2 The Center for Functional Connectomics, Korea Institute of Science and Technology, Seoul, South Korea, Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology (UST), Seoul, South Korea, 4 Laboratories of Excellence, Ion Channel Science and Therapeutics, Valbonne, France, 5 Institut National de la
Determinants of neonatal mortality among newborns admitted to neonatal intensive care unit Adama, Ethiopia: A case–control study

Context: The majority of problems during the early neonatal period are causally related with the fetal life or the birth process; while most problems during late neonatal life are acquired. Aims: This study aims to assess the determinant factors of neonatal mortality among newborns admitted to neonatal intensive care unit of Adama Hospital Medical College (AHMC). Setting and Design: An institutional-based retrospective case–control design was conducted at AHMC. Subjects and Materials: A total of 300 neonates study participants were recruited. Medical record review was employed to collect data. Statistical Analysis Used: Data were entered, cleaned, and analyzed by SPSS version 20 statistical package. Descriptive summaries using frequencies and proportions were used. Binary and multivariable logistic regressions were used. Results: Antenatal care, gravidity, and parity were significant factors to neonatal death. It was found that neonates who were born from mothers who had no antenatal care No single visit) had 2.7 times at risk of death (crude odds ratio = 2.7 95% confidence interval = 1.3, 5.6 adjusted odds ratio = 1.5 P = 0.008). Neonates who were delivered by assisted vaginal delivery were 5.9 times at risk of death than neonates who were delivered by singular value decomposition. It was found that asphyxia and neonatal death have a strong association. Conclusions: Antenatal follow-up, assisted vaginal delivery, cesarean delivery, gestational age, birth weight, sepsis, and asphyxia were significant neonatal risk factors for neonatal death. Most of these factors may be prevented and manageable by good antenatal care, intrapartum care, and neonatal care.
Lycopodium clavatum for the management of urolithiasis: A randomised double blind placebo controlled trial

Background: Urolithiasis is the most common disease of urinary tract found worldwide. There are several approaches for the treatment of urolithiasis that include the use of various synthetic and natural drugs and/or surgery in the conventional system of medicine. Objective: This study was taken up to evaluate the efficacy of Lycopodium clavatum in the management of urolithiasis. Materials and Methods: A multicentric, randomised, double-blind, placebo-controlled trial was conducted. Patients having symptomatology like Lycopodium clavatum were enrolled after screening and repertorisation as per the inclusion and exclusion criteria. During acute renal colic, despite group allocation, the patients were either prescribed the indicated homoeopathic medicines or conventional medicine. The analysis was carried out with an intention-to-treat approach, and missing values were handled using Last Observation Carry Forward method. Results: There was no statistical significance between the groups (P = 0.31) in reference to the number of cases in which stones expelled during the trial. The mean size of single stone expelled was 9.4 ± 4.9 and 13.9 ± 2.2 in Verum and Placebo groups, respectively (P= 0.12). There was also no significant difference in the mean size of mean size of multiple stones; in Verum group (10.1 ± 5.3) and Placebo group (16.1 ± 9.1) (P = 0.11). For assessment of pain and dysuria, Visual Analogue Scale was used, and a statistically significant difference was found between the groups (P = 0.039) for pain, and positive trend for Homoeopathy was noted for dysuria. A verified symptom syndrome of Lycopodium clavatum has been observed. Conclusion: Future studies with pragmatic study design and individualistic Homoeopathy can be undertaken to assess the effectiveness of treatment in urolithiasis.
Preconditioning in Cardiac Anesthesia…… Where are we?

Preconditioning, a milestone concept in the cardiovascular sciences introduced 32 years back by Murry. This concept opened a new era in the field of organ protection. To start with extensive studies done on ischemic preconditioning for myocardial protection, ischemic preconditioning is an endogenous science of cellular kinetics. Several components in signal transduction cascade have been identified but still some mechanisms not yet revealed. Anesthetic preconditioning also contributed a lot for myocardial protection and concreted the concept of preconditioning. We, with an inquisitive brain meticulously persuing newer methods of cardioprotection. Remote ischemic preconditioning (RIPC) is a brilliant example of it. RIPC can be future of cardioprotection, clinical trials and studies proved the benefits but yet to conclude the superiority of RIPC over myocardial ischemic cardioprotection. This review is an attempt to reveal this extraordinary concept with its basic cellular kinetics, methods, and recent trends.