Miracle-dz/UniFAR-FTUs huggingface dataset:
177 Lu-DOTA-Octreotate Therapy for Neuroendocrine Tumors: A Case Report and Review of the Literature

Favorable outcomes of peptide receptor radiotherapy of neuroendocrine tumors (NET) have been reported during the recent years. A patient with a non-functional neuroendocrine pancreatic carcinoma with abdominal lymph nodes and metastatic involvement of the liver is presented. After initial chemotherapy failure, he received 4 cycles of fractionated treatment with 177Lu-DOTA-octreoate (29,6GBq), which induced an impressive improvement of patient ś symptoms. We conclude that LuDOTA-octreotate fractionated therapy should be a therapeutic option for inoperable or metastasized NET patients promising symptomatic relief, and patients with large NETs expressing high somatostatin receptor density. I N T R O D U C T I O N Over the last decades, encouraging case reports of patients with neuroendocrine tumors (NET) undergoing peptide receptor radionuclide therapy (PRRT) have been increasingly published. PRRT, either with Yttrium (Y)-DOTA-octreotide (DOTATOC) or Lutetium (Lu)-DOTA-octreotate (DOTATATE), has been established as an efficient and effective therapeutic modality, relatively well tolerated with moderate toxicity, providing objective responses in NETs. Previously published studies have shown that PRRT could achieve objective tumor responses post traditional biologic and cytotoxic chemotherapeutic usage failure. Regarding dosimetry and therapy planning, experience with chemotherapy and external beam radiotherapy have been the reference points. However, there are important issues to be acknowledged. PRRT differs from chemotherapy and beam radiation due to the biological variables that influence radiation exposure. Dose radiation directed to tumor and normal surrounding tissues depends on tracer’s availability to target volume, relying on tumor size, somatostatin receptor density, and tracer’s pharmacokinetics. Therefore, a physician planning PRRT cannot precisely prescribe an absorbed tumor dose, but a certain amount or organ dose, considering patient’s general condition and previous treatments benefits. CASE REPORT Department of Nuclear Medicine, Evagelismos General Hospital of Athens, Athens, Greece Department of Oncology, Evagelismos General Hospital of Athens, Athens, Greece HOSPITAL CHRONICLES 2016, 11(2): 106–110
On the cloud observations in JAXA's next coming satellite missions

The use of JAXA’s next generation satellites, the EarthCARE and the GCOM-C, for observing overall cloud systems on the Earth is discussed. The satellites will be launched in the middle of 2010-era and contribute for observing aerosols and clouds in terms of climate change, environment, weather forecasting, and cloud revolution process study. This paper describes the role of such satellites and how to use the observing data showing concepts and some sample viewgraphs. Synergistic use of sensors is a key of the study. Visible to infrared bands are used for cloudy and clear discriminating from passively obtained satellite images. Cloud properties such as the cloud optical thickness, the effective particle radii, and the cloud top temperature will be retrieved from visible to infrared wavelengths of imagers. Additionally, we are going to combine cloud properties obtained from passive imagers and radar reflectivities obtained from an active radar in order to improve our understanding of cloud evolution process. This is one of the new techniques of satellite data analysis in terms of cloud sciences in the next decade. Since the climate change and cloud process study have mutual beneficial relationship, a multispectral wide-swath imagers like the GCOM-C SGLI and a comprehensive observation package of cloud and aerosol like the EarthCARE are both necessary.
Legendre Polynomials Operational Matrix Method for Solving Fractional Partial Differential Equations with Variable Coefficients

A numerical method for solving a class of fractional partial differential equations with variable coefficients based on Legendre polynomials is proposed. A fractional order operational matrix of Legendre polynomials is also derived. The initial equations are transformed into the products of several matrixes by using the operational matrix. A system of linear equations is obtained by dispersing the coefficients and the products of matrixes. Only a small number of Legendre polynomials are needed to acquire a satisfactory result. Results obtained using the scheme presented here show that the numerical method is very effective and convenient for solving fractional partial differential equations with variable coefficients.
Discontinuous Galerkin isogeometric analysis for segmentations generating overlapping regions

In the Isogeometric Analysis (IGA) framework, the computational domain has very often a multipatch representation. The multipatch domain can be obtained by a volume segmentation of a boundary represented domain, e.g. provided by a Computer Aided Design model. Typically, small gaps and overlapping regions can appear at the patch interfaces of such multipatch representations. In the current work, we consider multipatch representations having only small overlapping regions between the patches. We develop a Discontinuous Galerkin (DG)-IGA method that can be immediately applied to these representations. Our method appropriately connects the fluxes of the one face of the overlapping region with the flux of the opposite face. We provide a theoretical justification of our approach by splitting the whole error into two components: the first is related to the incorrect representation of the patches (consistency error) and the second to the approximation properties of the IGA space. We show bounds for both components of the error. We verify the theoretical error estimates in a series of numerical examples.
Pulse phase and precession phase resolved spectroscopy of Hercules X-1: studying a representative Main-On with RXTE

Aims. We performed a detailed pulse phase resolved spectroscopy of the accreting binary X-ray pulsar Her X-1 in the energy range 3.5–75 keV and have established pulse phase profiles for all spectral parameters. For three parameters, the centroid energy of the cyclotron line, the photon index and the flux of the 6.4 keV iron line, we have studied the variation as a function of 35 d phase. Methods. We analyzed RXTE observations of the Main-On of November 2002 using data from the PCA and the HEXTE instruments. Four different time intervals of about ∼1 d duration were selected to provide a good coverage of a complete Main-On. The intervals are centered at 35 d phases 0.03, 0.10, 0.15, and 0.20, respectively. Results. All spectral parameters show a strong modulation with pulse phase. While the centroid energy of the cyclotron line follows roughly the shape of the pulse profile, showing higher values close to the peak of the X-ray pulse, both the photon index and the iron line intensity exhibit distinct minima around the peak of the X-ray pulse. With respect to variations of the observed profiles with 35 d phase, we find that there is a clear evolution of the shape of the pulse profiles (flux versus pulse phase), a moderate increase of the maximum cyclotron line energy (found around pulse phase 0.7), but no significant evolution of the shape of the pulse phase profiles of the cyclotron line energy, the spectral power law index or the iron line intensity. Conclusions. The variation of spectral parameters as a function of the pulse phase provides important information about the system: i. the disappearance of the Fe line flux near the highest continuum flux may be an indication of a hollow cone geometry of the accretion structure; ii. the apparent non-dependence of the cyclotron line energy profiles on 35 d phase provides a new possibility to test the model of free precession of the neutron star, proposed to be responsible for the systematic variations in the pulse profiles.
Perceived tone "targets" and pitch accent identification in Italian

This study investigates the role of temporal alignment, F0 and peak shape in determining perceived tonal target values in Neapolitan Italian. In this variety, the alignment of the accent peak appears to be a strong perceptual cue to the question/statement identification (d'Imperio and House, 1997), everything else being equal. In the present study, the contour of a question, uttered by a female speaker of Neapolitan Italian, was stylized and resynthesized means of PSOLA. A set of stimuli was created in which either tonal alignment was varied, while height was kept constant, or height was varied orthogonally toent. For the alignment manipulation, an additional variable was the shape of the accent peak, which could be either flat (creating a short plateau) or sharp. Thirty Neapolitan subjects listened to the stimuli and identified each as a question or a statement. The results suggest that the contribution of peak height to the question/statement identification is much less important than that of target alignment. Moreover, peak shape affects the perceived alignment of the target tone, in that flat peak stimuli cause the perceived target to be displaced towards the end of the plateau.
Geoscience Education in the Boy Scouts of America

ABSTRACT Boy Scout geoscience education is not “desk” education—it is an informal, hands-on, real-world education where Scouts learn through activities, trips, and the outdoors, as well as in meetings and in the merit badge program. Merit badge requirements, many of which meet National Science Education Standards for Earth and Space Science, give boys foundational experiences and familiarity with geoscience topics. Earning a Geology merit badge at any location resulted in a significant gain of content knowledge (P < 0.001). The combined treatment groups for all location types had a 9.2% gain in content knowledge, but the amount of content knowledge acquired through the merit badge program varied with location. The longitudinal posttest scores, with a 15.0% increase from the attributed average pretest score, were higher than the posttest scores from any location except summer camp. No gains were seen in the control group; age and grade were not significant factors. Combining interview data with quantitative data indicates that Scouts who participate in the Geology merit badge are better prepared for school geoscience classes. Participation in the Geology merit badge provides geoscience experiences and “familiarity” with geoscience concepts that allow Scouts to create and retain geoscience knowledge.
Theoretical and Practical Considerations for Using Phase Change Materials Into Spanish Banking Office

The service sector accounted for nearly 10 % of the total final energy consumption in Spain (414,692.157 GJ) in 2010, with the largest consumers being in the office sector and an increasing trend is expected in the coming years. Greenhouse gases (GHG) emitted by the commercial and institutional sector were the equivalent of approximately 8.2 Mt of CO2. Consequently, energy savings in this sector offer the best means of reducing the energy demand. Banking sector within the service sector have been studied in a previous research by authors where regression models for the prediction of the annual energy consumption in the Spanish banking sector were presented. Results provided relevant information on the energy performance of the Spanish banking sector and contribute new data for the energy performance of the sector. From this study, it was found that a balance between comfort and energy efficiency represents a great challenge. Within this scenario Phase Change Materials (PCMs) are willing to be studied and compared for obtain the above mentioned balance because they can passively cool and heat a living area without the need of including heavy mass or extra space typically required by sensible heat storage materials. It has been demonstrated that for the development of a latent heat storage system (LHTS) in a building fabric, the choice of the PCM is key to improve the heat transfer mechanism in the building. They can be incorporated in the walls, ceiling and floor of buildings for further thermal energy storage and will help in reducing energy demands associated with temperature control. The potential for PCMs is great. For example, converting 0.45 kg of ice at 0 °C to 0.45 kg of water at 0 °C requires the “storage” of about 1.055 MJ, conversely, about 1,000 Btu are released as the water freezes. A temperature change of 5/9°C requires about 1.42 m 3 (3,175.75 kg) of concrete to store 1.055 MJ. The reduction in mass and volume offered by PCM use is potentially enormous. To this end, this research develops an analysis to show environmental considerations regarding two PCMs that can be used into Spanish banking offices which have energy consumption behaviour different to residential sector. The analysis takes into account Spanish climatic severities and proposes essential strategies for planning and promoting different methods to decrease its environmental impact, to lower the consumption of energy resources, and to reduce economic costs.
Semiregular automorphisms in vertex-transitive graphs with a solvable group of automorphisms

It has been conjectured that automorphism groups of vertex-transitive (di)graphs, and more generally 2 -closures of transitive permutation groups, must necessarily possess a fixed-point-free element of prime order, and thus a non-identity element with all orbits of the same length, in other words, a semiregular element. The known affirmative answers for graphs with primitive and quasiprimitive groups of automorphisms suggest that solvable groups need to be considered if one is to hope for a complete solution of this conjecture. It is the purpose of this paper to present an overview of known results and suggest possible further lines of research towards a complete solution of the problem.
Proniosome: A Novel Non-ionic Provesicules as Potential Drug Carrier

Vesicular systems are a novel means of drug delivery that can enhance the bioavailability of encapsulated drug and provide therapeutic activity in a controlled manner for a prolonged period of time. Liposomes were the first such system, but they suffer from a number of drawbacks including high cost and lack of stability at various pHs. To avoid the drawback of liposomes, niosomes were invented, which can be easily and reliably made in the laboratory. Niosomes are the ideal means of drug delivery that can enhance the bioavailability of encapsulated drug by various mechanisms and provide a therapeutic activity for a prolonged period of time. However, they suffer from aggregation, fusion, leaking, sedimentation of vesicles, and difficulty in sterilization; so to overcome these problems, a newer approach was employed which is known as pro-vesicular carriers. Here, in this review, we elaborate one of the pro-vesicular carriers, widely known as proniosome. This review covers all the aspects of proniosomes including mechanism, formulation variables and their effects, methods of preparation, parameters for characterizations, and application.
Evaluation of Obesity from BMI and Body Fat Rate, and Its Association with Coronary Risk Factors in Health Checkup Examinees

Abstract To evaluate the degree of obesity based on differential combinations of BMI and body fat ratio, and thereby to obtain the comprehensive determination of coronary heart disease risk factors. The present study was conducted among 3,731 individuals(male; 2,312, female; 1,419) who underwent general health checkup in the general health promotion center in a university hospital during 2-year period from Jan. 2008 to Dec. 2009. Based on the obesity categories from combinations of BMI and body fat ratio, 30.2% were「normal」, 8.9% were「seemingly obese」, 31.2% were「occult obese」, and 29.8% were「obese」. By sexual comparison, the proportion of 「normal」and 「seeming obese」individuals were higher in men than women, while 「occult obese」and 「obesity」individuals were preponderant in women compared to men. By age, the proportion of 「obesity」individuals were higher in the 40' and 50's than in 30's and 60's. Based on the association between obesity categories and each of CRF, SBP, DBP, TC, HDL-C, LDL-C and TG was significantly higher in 「seeming obese」and 「obesity」group than in 「normal」group, but SBP, TC and LDL-C was significantly higher in 「occult obese」and 「obesity」group than in 「normal」group. For odds ratios of each of CRF for obesity categories, it was higher in「obesity」group, 「seeming obese」group, 「occult obese」group than in 「normal」group in that order. Key Words : BMI , Bod y Fat Rate Coronar Risk Factors
gR: A GPU-based Router

With the growing internet traffic and complexity of packet processing task, the throughput of routers is affected. Also modern routers need to provide additional services like security, QOS which further adds to the complexity. These issues can be addressed with the massive parallel computing capability of graphic processors. In this paper, we offload two of the most computationally intensive tasks namely lookup and two-key IPSec to CUDA-enabled GPU. The execution time is reduced by exploiting the inherent parallelism in packet processing tasks. Finally, we have analyzed the performance variations and have found that modern graphic cards can be effectively used to speed up router operations.
Moving the Frontier of Quantum Control into the Soft X-Ray Spectrum

The femtosecond nature of X-ray free electron laser (FEL) pulses opens up exciting research possibilities in time-resolved studies including femtosecond photoemission and diffraction. The recent developments of seeding X-ray FELs extend their capabilities by creating stable, temporally coherent, and repeatable pulses. This in turn opens the possibility of spectral engineering soft X-ray pulses to use as a probe for the control of quantum dynamics. We propose a method for extending coherent control pulse-shaping techniques to the soft X-ray spectral range by using a reflective geometry 4f pulse shaper. This method is based on recent developments in asymmetrically cut multilayer optic technology and piezoelectric substrates.
Anti-Infl ammatory Activity of Ethanolic Leaf Extracts from Adenanthera pavonina (L) in Rats

Ethanolic extracts from the leaves of Adenanthera pavonina were assessed at doses of 250 and 500 mg/kg for anti-ins ammatory effects using both acute and chronic ins ammatory models. The anti-diarrheal activity was also evaluated to support any possible evidence of prostaglandin synthesis inhibition. It was found that the doses possessed inhibitory effects on the acute phase of ins ammation as seen in carrageenan-induced hind paw edema as well as in a subacute study of cotton pellet-induced granuloma formation. The anti-ins ammatory activity elicited by the leaf extracts may be due to the ins uence of the active constituents such as beta-sitosterol and stigmasterol. A possible mechanism may also be due to the inhibition of prostaglandin synthesis which is also evidenced by the delay in the formation of wet faeces. Further study is required to postulate the exact molecular mechanism involved in this process of inhibition of ins ammation by these leaf extracts. Key words: Adenanthera, anti-ins ammatory, cotton pellet, paw edema.
A more general effective-viscosity hypothesis

A discussion of the applicability of an effective-viscosity approach to turbulent flow suggests that there are flow situations where the approach is valid and yet present hypotheses fail. The general form of an effective-viscosity formulation is shown to be a finite tensor polynomial. For two-dimensional flows, the coefficients of this polynomial are evaluated from the modelled Reynolds-stress equations of Launder, Reece & Rodi (1975). The advantage of the proposed effective-viscosity formulation, equation (4.3), over isotropie-viscosity hypotheses is that the whole velocity-gradient tensor affects the predicted Reynolds stresses. Two notable consequences of this are that (i) the complete Reynolds-stress tensor is realistically modelled and (ii) the influence of streamline curvature on the Reynolds stresses is incorporated.
Chlorophyll a as a marker for bioturbation and carbon flux in southern and central North Sea sediments

In 1993, 3 stations (depth 28 to 49 m) In the southern and central North Sea were visited to study the relationship between phytopigment input to the sediment and the subsequent response by the ben th~c community. Duplicate sediment cores were taken, s h e d and analysed for chlorophyll a, and sediment oxygen demand was measured. The downcore distribution of chlorophyll a was modelled with both a random diffusive model and a non-local mixing model. In most cases, the random diffusive model gave the best fit. In some cases, however, when a subsurface maximum of chlorophyll was found, the non-local mixing model gave a better description of the depth-distribution of chlorophyll. From these models, the bloturbation rates in and the fluxes of chlorophyll a to the sediments were calculated. Fluxes were also calculated according to the inventory of chlorophyll in the sediments. Results from these 2 methods correlated well. Fluxes were highest in spring, lower in summer and lowest in autumn and winter. At one station a good correlation between the chlorophyll flux to the sediment and the bioturbation rate was found. Another station demonstrated a positive trend between these 2 parameters, and the third station showed no relation at all. Sediment oxygen demand a1 the 3 stdtions exhibited a clear seasonal cycle, with high values in mid or late summer When both chlorophyll fluxes and sediment oxygen demand were converted into carbon units, the annual averages of carbon supply (chlorophyll) and carbon mineralisation (oxygen demand) were reasonably balanced. It appeared that In spring, carbon build-up took place, while in late summer this carbon was degraded. It is argued that chlorophyll a is a good marker for metabolisable organlc matter K E Y WORDS. Benthic-pelagic coupling . Phytopigments . Bioturbation . Carbon budget
Hydrology shapes taxonomic and functional structure of desert stream invertebrate communities

Hydrology is a fundamental factor influencing ecosystem dynamics, life-history strategies, and diversity patterns in running-water habitats. However, it remains unclear how hydrology may structure the taxonomic and functional composition of communities, especially in systems with high spatiotemporal variability in flow. We examined invertebrate diversity from 7 desert streams in the Huachuca Mountains of southeastern Arizona, USA, that span a flow permanence continuum from highly intermittent to perennial. We examined the relative roles of flow permanence, habitat size, season, and microhabitat in determining taxonomic and functional structure (according to 7 species traits compiled for 234 taxa) of these communities. We predicted that both functional and taxonomic diversity would be positively related to flow permanence and negatively related to the duration and number of stream drying events. As predicted, increased flow permanence was associated with increased functional richness, functional evenness, and taxonomic richness. Conversely, drying events reduced functional diversity across all measured indices. We found a saturating relationship between functional richness and taxonomic richness, indicating functional redundancy in species-rich communities, which may promote resilience of ecosystem function to environmental variation. Our study adds further evidence that hydrology is a key determinant of aquatic invertebrate diversity, and that stream hydroperiod strongly influences both functional and taxonomic diversity in arid-land streams.
Classification and Ideology--A Critical Discourse Analysis of Bush's Two Speeches on 911 Attack

The beginning of the 21st century witnessed a terrible event— 911 attack in 2001. Right after the attack, the thenPresident George Bush delivered a speech. On the fifth anniversary, President Bush addressed the whole nation again.One salient linguistic feature in two speeches is classification. A critical discourse analysis of Bush’s two speechesreveals Bush’s deep-rooted ideology that America is the most powerful and dominant country in the world.