Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-term outcomes of nasopharyngeal carcinoma patients with T1-2 stage in intensity-modulated radiotherapy era

Objectives: To evaluate long-term outcomes and late toxicities of nasopharyngeal carcinoma (NPC) patients with T1-2N0-3M0 stage in intensity-modulated radiotherapy (IMRT) era. Materials and Methods: From June 2005 to October 2013, 276 patients confirmed T1-2N0-3M0 NPC treated with IMRT were reviewed, with 143 (51.8%) N0-1 disease and 133 (48.2%) N2‐3 disease. Among them, 76.4% received chemotherapy. The prescribed doses given to the primary tumor and lymph nodes were 66Gy in 30 fractions. Results: After a median follow-up of 103 months, the 5-year and 10-year overall survival (OS) were 90.6% and 79.2%. The 5-year and 10-year local control (LC) rate, regional control (RC) rate and distant metastasis free survival (DMFS) were 97.0% and 91.9%, 94.1% and 92.2%, 89.4% and 87.0%, respectively. The 5-year and 10-year OS, RC rate and DMFS of N0-1 compared with those of N2-3 were 98.6% vs. 82.0% and 86.8% vs. 70.9% (P=0.000), 99.3% vs. 88.3% and 99.3% vs. 84.1% (P=0.000), 97.9% vs. 80.1% and 95.7% vs. 77.5% (P=0.000). The incidence of 3-4 late toxicities were low and mainly xerostomia and hearing deficit. The rates of radiation-induced cranial nerve palsy and temporal necrosis were 2.5% and 2.5%, respectively. Eighteen patients had the second primary tumor, of whom eight were lung cancer, six were head and neck cancer, four were others. Conclusions: Satisfactory locoregional control was achieved in T1‐2N0-3M0 NPC treated with IMRT. Distant metastasis was the main failure cause and N2-3 was the main adverse prognostic factor. Second primary tumor occurred 6.5% and negatively impacted OS in NPC.
Right Ventricle Remodeling Metabolic Signature in Experimental Pulmonary Hypertension Models of Chronic Hypoxia and Monocrotaline Exposure

Introduction: Over time and despite optimal medical management of patients with pulmonary hypertension (PH), the right ventricle (RV) function deteriorates from an adaptive to maladaptive phenotype, leading to RV failure (RVF). Although RV function is well recognized as a prognostic factor of PH, no predictive factor of RVF episodes has been elucidated so far. We hypothesized that determining RV metabolic alterations could help to understand the mechanism link to the deterioration of RV function as well as help to identify new biomarkers of RV failure. Methods: In the current study, we aimed to characterize the metabolic reprogramming associated with the RV remodeling phenotype during experimental PH induced by chronic-hypoxia-(CH) exposure or monocrotaline-(MCT) exposure in rats. Three weeks after PH initiation, we hemodynamically characterized PH (echocardiography and RV catheterization), and then we used an untargeted metabolomics approach based on liquid chromatography coupled to high-resolution mass spectrometry to analyze RV and LV tissues in addition to plasma samples from MCT-PH and CH-PH rat models. Results: CH exposure induced adaptive RV phenotype as opposed to MCT exposure which induced maladaptive RV phenotype. We found that predominant alterations of arginine, pyrimidine, purine, and tryptophan metabolic pathways were detected on the heart (LV+RV) and plasma samples regardless of the PH model. Acetylspermidine, putrescine, guanidinoacetate RV biopsy levels, and cytosine, deoxycytidine, deoxyuridine, and plasmatic thymidine levels were correlated to RV function in the CH-PH model. It was less likely correlated in the MCT model. These pathways are well described to regulate cell proliferation, cell hypertrophy, and cardioprotection. These findings open novel research perspectives to find biomarkers for early detection of RV failure in PH.
On Phase Identification of Hardened Cement Pastes by Combined Nanoindentation and Mercury Intrusion Method

The micro-mechanical properties of hardened cement paste can be obtained by nanoindentation. Phases at different locations can generally be determined by using the Gaussian mixture model (GMM) method and the K-means clustering (KM) method. However, there are differences between analysis methods. In this study, pore structure and porosity of hardened cement paste aged three, seven, and 28 days were obtained by mercury intrusion porosimetry (MIP), and their micro-mechanical properties were obtained by the nanoindentation method. A new method, GMM-MIP and KM-MIP, was proposed to determine the phase of hardened cement paste based on the pore structure and nanoindentation results. The results show that GMM-MIP and KM-MIP methods are more reasonable than GMM and KM methods in determining the phase of hardened cement paste. GMM-MIP can be used to obtain reasonable phase distribution. If the micro-mechanical properties of each phase in hardened cement paste do not satisfy the normal distribution, the GMM method has significant defects.
Elasto-Plastic Fatigue Crack Growth Behavior of Extruded Mg Alloy with Deformation Anisotropy Due to Stress Ratio Fluctuation

Fatigue crack growth (FCG) experiments were performed using a low-temperature extruded magnesium alloy AZ31 with texture. Under a constant maximum stress intensity factor (Kmax), the stress ratio R was changed from 0.1 to −1 during the fatigue crack growth process, and the FCG behavior before and after the R change was investigated. As a result, tensile twins were generated owing to the fatigue load on the compression side of R = −1, and the FCG velocity was accelerated. In addition, when the maximum compressive stress at R = −1 (|(σmin)R = −1|) exceeded the compressive yield strength of the material (σcy), the FCG velocity after R fluctuation greatly accelerated. On the other hand, under the condition |(σmin)R = −1| < σcy, the degree of acceleration of the FCG velocity due to R fluctuation was small. In either case, the degree of acceleration in the FCG increased as the Kmax value increased. The above FCG acceleration mechanism due to the R fluctuation was considered based on the observation of the deformation and twinning states of the fatigue crack tip, the fatigue crack closure behavior, and the cyclic stress–strain curve of the fatigue process. The FCG acceleration mechanism was as follows: First, the driving force of the FCG increased owing to the increase in crack opening displacement due to the generation of tensile twins. Second, the coalescence of the main crack and a plurality of microcracks were generated at the twin interface. The elasto-plastic FCG behavior after the stress ratio fluctuations is defined by the effective J-integral range ΔJeff.
The Allium Derivate Propyl Propane Thiosulfinate Exerts Anti-Obesogenic Effects in a Murine Model of Diet-Induced Obesity

Allium species and their organosulfur-derived compounds could prevent obesity and metabolic dysfunction, as they exhibit immunomodulatory and antimicrobial properties. Here, we report the anti-obesogenic potential and dose-dependent effects (0.1 or 1 mg/kg/day) of propyl propane thiosulfinate (PTS) in a murine model of diet-induced obesity. The obesogenic diet increased body weight gain and adipocyte size, and boosted inflammatory marker (Cd11c) expression in the adipose tissue. Conversely, PTS prevented these effects in a dose-dependent manner. Moreover, the higher dose of PTS improved glucose and hepatic homeostasis, modulated lipid metabolism, and raised markers of the thermogenic capacity of brown adipose tissue. In the colon, the obesogenic diet reduced IL-22 levels and increased gut barrier function markers (Cldn3, Muc2, Reg3g, DefaA); however, the highest PTS dose normalized all of these markers to the levels of mice fed a standard diet. Gut microbiota analyses revealed no differences in diversity indexes and only minor taxonomic changes, such as an increase in butyrate producers, Intestimonas and Alistipes, and a decrease in Bifidobacterium in mice receiving the highest PTS dose. In summary, our study provides preclinical evidence for the protective effects of PTS against obesity, which if confirmed in humans, might provide a novel plant-based dietary product to counteract this condition.
An efficient root transformation system for CRISPR/Cas9-based analyses of shoot–root communication in cucurbit crops

Abstract Cucurbit crops are suitable models for studying long-distance signaling in horticultural plants. Although thousands of substances are graft transmissible in cucurbits, functional studies have been hampered by the lack of efficient genetic transformation systems. Here, we report a convenient and efficient root transformation method for several cucurbit crops that will facilitate studies of functional genes and shoot–root crosstalk. We obtained healthy plants with completely transformed roots and non-transgenic shoots within 6 weeks. Furthermore, we combined this root transformation method with grafting, which allowed for gene manipulation in the rootstock. We validated our system by exploring salt tolerance mechanisms using a cucumber (Cucumis sativus)/pumpkin (Cucurbita moschata Duch.) (scion/rootstock) graft in which the sodium transporter gene High-affinity K+ transporter1 (CmoHKT1;1) was edited in the pumpkin rootstock and by overexpressing the pumpkin tonoplast Na+/H+ antiporter gene Sodium hydrogen exchanger4 (CmoNHX4) in cucumber roots.
Interpersonal negotiation skills in ADHD

ABSTRACT Social interaction difficulties are amongst the most prevalent and pervasive adverse outcomes for children and adolescents with ADHD. Problem-solving strategies are impaired in affected individuals, according to the literature. This study aimed to investigate the social problem-solving skills of children and adolescents with and without ADHD, using objective quantitative measures provided by the Interpersonal Negotiation Strategies Interview (INSI). Since verbal communication skills and working memory may be impaired in ADHD, we investigated their contribution to the performance. Forty-three children and adolescents with ADHD and 27 clinical controls with clinical diagnoses other than ADHD completed the INSI along with measures of verbal communication skills (Verbal Comprehension Index [VCI]): Similarities, Vocabulary and Comprehension subtests from the Wechsler Battery, visual (Corsi Blocks) and verbal (Digit Span) working memory tasks. Groups performed similarly on measures of intellectual functioning, working memory, and verbal communication. For the entire sample, VCI scores were positively correlated with INSI performance scores. The ADHD group performed worse on the INSI than the clinical control group. Linear regression analysis showed that inattention and hyperactivity/impulsivity levels and Similarities predicted INSI’s performance. Our findings indicate that interpersonal negotiation difficulties in ADHD are related to DSM-5 defining symptoms of the disorder.
PID control in adjustable-pitch wind turbine system based on BP neural network

In order to solve non-linear,parameter time changing,anti-disturb and time-lag problems,a PID control method based on the BP neural network has been presented and applied in the variable speed(adjustable) pitch wind turbine control system,in which the pitch exactor is driven by hydraulic unit.After analyzing the hydraulic oil path,transform function model and parameter changing at three kinds of(operation)(conditions,) the BP neural network PID control principles has been described. (Moreover,) the(comparison) and simulation results for the design data of 7.5? kW trial variable speed constant frequency wind turbine have been performed.
Research on the Relationship between Self-efficacy and Inquiry Community Model

Online learning has the characteristics of large-scale, online and open implementation. It provides students with rich high-quality online learning resources and attracts a large number of learners. Exploring the teaching effect in the online and offline mixed environment has become a hot research topic. Thus, based on a comprehensive review of the literature on the interaction between self-efficacy and the exploratory community model, this paper establishes two models that affect cognitive existence. Using teaching existence and social existence, and taking self-efficacy as the intermediary variable, this paper analyzes the relationship in the exploratory community model. The results show that the overall Cronbach’s α coefficient is 0.933 and the KMO value is 0.923, indicating that the questionnaire designed has good reliability and validity. Teaching presence and social presence plays a significant positive role in cognitive presence. Self-efficacy plays a complete and partial mediating role in teaching presence and social presence and has a significant positive effect on cognitive presence. The results of this paper have important reference value for expanding the framework of an inquiry community, realizing the deep construction of learners' knowledge connotation, analyzing the influence mechanism of teachers and students in network teaching, and enriching the application of the inquiry community model.
Comparison of Emotional Speech Detection Algorithm for Glottal Closure Instants

Epochs or glottal closure instants are periods of high vocal tract stimulation during speech production. Among other applications, GCI extraction is utilized in prosody modification, speech synthesis, and voice source analysis as a pre-processing step in speech technology. Many of the GCI detection techniques developed throughout time are compatible with speech signals produced by modal phonation, thus these algorithms work well with them. ” For emotive speech, however, a comparison of several cutting- edge GCI detection methods is required. Emotional speech and well-known evaluation criteria are used in this research to evaluate GCI detection techniques. This collection contains recordings of seven distinct emotions, as well as factual information like electro glotto graphy(EGG). All six GCI identification algorithms perform well in neutral emotion speech processing, but they struggle in high arousal speech processing (anger and joy). GCI detection in emotional speech may be aided by local average pitch period estimates, according to the findings of the study.
Application research of improved BP algorithm in process neural networks

Process Neural Networks(PNN) is a kind of new ANN based on Process Neuron,its inputs and weights are all functions associated with 'time'. In this paper,aiming at the disadvantages of BP algorithm,a kind of Improved BP algorithm was applied to the training of PNN which advanced the learning efficiency of PNN as well as expanded the algorithm theory of PNN to some extent.In the process of application of Improved BP algorithm in PNN,the input functions and the network weight functions are represented as expansion of a same orthogonal function basis. At the end of the paper,on the basis of Improved BP algorithm,PNN was applied to the forecast of aircraft EGT Index which proved the effectiveness of the algorithm as well as indicated the good future of PNN.
IEEE Transactions on Biomedical Engineering

Guest Editors : Miguel Nicolelis, M.D., Ph.D. Professor of Neurobiology, Biomedical Research and Experimental Psychology. Department of Neurobiology, Box 3209, Room 327E Bryan Research Bldg. Duke University Medical Center 101 Research Drive Durham, NC 27710 e-mail: nicoleli@neuro.duke. edu Neils Birbaumer, Ph.D. Professor of Behavioral Neurobiology Faculty of Medicine Inst. Medical Psychology and Behavioral Neurobiology Gartenstr. 29, D-72074, Tübingen Germany e-mail: niels.birbaumer@unituebingen.de Klaus Müeller, Ph.D. University of Potsdam and Fraunhofer Institut FIRST Intelligent Data Analysis Group (IDA) Kekulestr. 7, 12489 Berlin
Extended discrete‐time transfer matrix approach to modeling and decentralized control of lattice‐based structures

This paper presents the modeling and control of an aircraft wing structure constructed by lattice‐based cellular materials/components. A novel model reduction process is proposed that utilizes the extended discrete‐time transfer matrix method (E‐DT‐TMM). Through recursive application of the E‐DT‐TMM, an effective reduced‐order model can be obtained in which a decentralized discrete‐time linear quadratic regulator (LQR) controller can be designed. To demonstrate the efficiency of the proposed concept, a prototype wing structure is studied. The analysis and simulation results show that the performance of the proposed E‐DT‐TMM based decentralized LQR controller is comparable with that of the full‐state continuous LQR controller. Copyright © 2016 John Wiley & Sons, Ltd.
Economic Analysis of the Solar Thermal Power Generation System Integrated With a Pulverized Coal Fired Boiler

Two layout schemes,the arrangement before and after economizer,were proposed for the pulverized boiler integrated with solar energy from parabolic trough collectors considering material flows matching energy flows.Based on the thermal performance of parabolic trough collectors and the variant condition computation of boiler,the performance analysis models of two integration arrangements were built.Taking 600 MW subcritical boiler and the LS-2 trough collectors for example,the performance of both schemes were investigated and compared.The thermal economic rules for both integration arrangements were summarized in accordance with the simulation results.The economic analysis of the both integration arrangements show that the solar LEC of both schemes is lower than that of solar energy generating systems(SEGS),and while CO2avoidance is included,the solar LEC is much lower and that the solar LEC of the arrangement before economizer is lower than that of the arrangement after economizer.The solar LEC of both integration arrangements is influenced by the direct solar irradiance,the economic life of the integration systems,coal and CO2 price,the cost of the trough collector.
Green Building Challenge '98 : International strategic considerations

Nils Larsson gives a brief overview of Green Building Challenge '98, an international building performance assessment project that has been launched by CETC, Natural Resources Canada and the Green Building Information Council. It argues that the assessment framework developed, GBC '98, will have a strategic value as a second-generation performance assessment system for a wide variety of applications, including the specification of building performance and as a tool for green labelling systems.
Tratamento de Concessão e Revogação de Acesso a Registros Eletrônicos de Saúde em Blockchain

O compartilhamento de registros eletrônicos de saúde é extremamente importante para a melhoria e agilidade dos procedimentos médicos em relação ao paciente. Estes registros são considerados altamente críticos em relação à segurança e o acesso a eles deve ser controlado de forma segura e eficaz. O controle desses dados pode ser realizado de maneira tradicionalmente centralizada, porém, com a utilização da tecnologia blockchain, o controle dos registros se torna seguro, transparente e com histórico das transações. Neste artigo, apresentamos uma estrutura para a utilização de blockchain no controle de acesso e compartilhamento de registros eletrônicos de saúde. Essa estrutura é capaz de manter o controle de posse dos dados por meio de autorização e revogação de permissões relacionadas aos dados individualizados de maneira simples e eficiente. O controle das permissões centrado no paciente resultou em vantagens de segurança em relação à legislação e ao compartilhamento fragmentado dos dados entre paciente, médicos e instituições de saúde.
Scope and Sequence

1 /s/, /ee/, see segmenting, blending, decoding 2 /v/, /n/, /an/ segmenting 3 Vee, San, van blending, decoding 4 the decoding, word reading 5 review of learned elements decoding, word reading, story reading, reading comprehension 6 /c/, /l/, /cl/ segmenting 7 can, Lee segmenting, blending, capitalization, decoding, word reading 8 /sl/, /sn/, /fr/, /f/, /r/, /fl/, /cr/ segmenting 9 Fran, feels segmenting, blending, decoding, capitalization, word reading 10 fan, ran blending, decoding, word reading, sound-production firming
Dual In-Syringe Microextraction with Electrothermal Vaporization (ETV) Inductively Coupled Plasma–Mass Spectrometry (ICP–MS) for Determination of Rare Earth Elements (REEs) in Food

Abstract In-syringe micro-solid phase extraction (IS-MSPE) was coupled with in-syringe vortex-assisted solidified floating organic drop microextraction (IS-VA-SFODME) for the determination of rare earth elements (REEs) by electrothermal vaporization inductively coupled plasma–mass spectrometry. Firstly, IS-MSPE was used for enriching REEs and eliminating the matrix components from samples. In the next step, the eluent from IS-MSPE was utilized for further enrichment of REEs by IS-VA-SFODME. This procedure exhibited high efficiency and good selectivity without tedious centrifugation/filtration operations. The primary factors affecting preconcentration, separation and determination of REEs were investigated. The enrichment factors (EFs) ranged from 267-fold to 523-fold for REEs. Under the optimized conditions, the detection limits for REEs were from 0.002 to 0.065 ng L − 1 with relative standard deviations between 4.6 and 9.1%. This method was used for the determination of REEs in food certified reference materials, and the determined results were in good agreement with the certified values.
A Matric for Sound Quality Evaluation of Car's Door-slamming

A new parameter for sound quality evaluation of car’s door-slamming,sound metric based on Hilbert-Huang transform(SMHHT) was developed.At first,the sound signals of door-slamming were sampled,decomposed by EMD and transformed by Hilbert Transform.Then,using the instantaneous frequency,the corresponding IMF components were weighted by critical frequency band,their energies were calculated,and the new sound metric SMHHT for sound quality evaluation was determined.In order to verify the effectiveness of the new sound metric,correlation analyses between the new sound metric and the subjective evaluation results,and between the traditional sound quality evaluation parameters,including loudness and sharpness,and the subjective evaluation results were carried out respectively.The result shows that the new sound metric proposed in this paper has a higher correlation with the subjective evaluation values than the other.Thus,the new sound metric can evaluate the door-slamming sound quality more accurately.
Study on Improvement of Common Railway Passenger Fare System

Level of railway passenger fare is an important factor affecting traffic and effectiveness of railway companies.Despite of several adjustments to China's railway passenger fare system,but there are still many unreasonable existing in need of improvement.This paper point out that the existence passenger fare system is imperfect,common rail fares are low,new air-conditioned car is "Speed does not raise prices," seat and no seat fares are the same when calculating the fares and so on.Making railway’s attribute clear and supervising the cost,new air-conditioned train is "Speed increase price ",implementation of seasonal tariffs,implementation of regional tariffs,appropriate fares of fine train goes up,increasing seat tickets and other measures and proposals are provided.