Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunolocalization of neurokinin 1 receptor in WHO grade 4 astrocytomas, oral squamous cell and urothelial carcinoma.

INTRODUCTION Neurokinin-1 receptor (NK-1R) induces inflammatory reactions in peripheral tissues but its regulatory effects in target tissues is dependent on receptor signalling. Substance P (SP) has a high affinity for the NK-1R, to which it binds preferentially. We aimed to investigate the expression of NK-1R in World Health Organization (WHO) grade 4 astrocytomas as well as in oral squamous cell carcinoma (OSCC) and urothelial carcinoma, and its association with disease progression. MATERIAL AND METHODS The study included tissue samples from 19 brain astrocytomas, 40 OSCCs and 10 urothelial carcinomas. NK-1R expression was quantitatively assessed in the tumour cells using immunohistochemistry. The relationship between NK-1R expression in astrocytomas and recurrence-free interval has been explored. RESULTS The results showed that the NK-1R was intensely expressed in patients with WHO grade 4 astrocytoma, OSCC and urothelial carcinoma. However, cases clinically diagnosed as a low-grade cancer showed reduced NK-1R expression. CONCLUSIONS NK-1R is overexpressed in all cases of WHO grade 4 astrocytoma, OSCC and urothelial carcinoma. The ubi-quitous presence of SP/NK-1R complex during tumour development and progression suggests a possible therapeutic key strategy to use NK-1R antagonist as an adjuvant therapy in the future.
Cultural and Creative Product Design and Image Recognition Based on the Convolutional Neural Network Model

The development in technology has resulted in the utilization of artificial intelligence systems in various fields. In this research, we are going to study cultural and creative product design and image recognition based on a convolutional neural network (CNN) model. A convolutional neural network is referred to as a type of artificial neural network (ANN) that is used to analyze visual images. Our proposed system deploys a convolutional neural network model for image recognition in the field of cultural and creative product design. Cultural and creative products are becoming more popular these days. The cultural and creative products are referred to as innovative products or innovative new product design which makes use of the cultural symbols and other cultural factors in their design. In simple words, it is the integration of culture and creativity in a new product design. The main aspect of cultural creative products is the incorporation of cultural features into a new product, thus obtaining a creative- and culture-based product. The study results have proved that CNN has provided an accuracy of 87%.
Civilian Military Security Coordinators Coping with Frequent Traumatic Events: Spirituality, Community Resilience, and Emotional Distress

Civilian military security coordinators are a unique kind of first responders. They live in communities that are close to the border and are responsible for the security of their community in routine and emergency situations until the arrival of the army or the police. Their role puts them at an elevated risk of experiencing emotional distress and developing PTSD. The present study, which was conducted in Israel following terror incidents over the year 2018, aimed to examine the relationships between spirituality and perceived community resilience, on the one hand, and PTSD symptoms and stress, on the other, among civilian military security coordinators. One hundred and thirteen (n = 113) civilian military security coordinators living up to 12.4 miles from the border who are routinely exposed to terror and other traumatic events completed demographic, spirituality, community resilience, PTSD, and stress questionnaires. Structural-equation-model analyses showed that spirituality was negatively associated with PTSD symptoms and stress. However, perceived community resilience was not associated with PTSD symptoms or stress. In addition, age was negatively associated with PTSD symptoms and stress. Financial situation was also negatively associated with PTSD symptoms and stress and incidence of exposure to terror and security threats was associated only with PTSD symptoms. Theoretical and practical implications are discussed.
Online voltage stability monitoring using VAr reserves

For many years, system operators have noticed that the VAr reserves of key generators can indicate the degree of controllability of key bus voltages in a system. This observation has led to the development of a few VAr reserve monitoring systems. In this paper, a rigorous investigation on the subject is conducted. Using the correlative relationship between generator VAr reserves and system voltage stability margins, a practical and systematic method for online voltage stability monitoring is proposed. The method has been thoroughly tested on two real-life power systems with promising results.
Decentralized Collaborative Decision-Making for Topology Building in Mobile Ad-Hoc Networks

In ad-hoc networks with a large number of mobile participants, i.e. nodes, centralized decision-making for building the network topology becomes impracticable. At Airbus, an architecture for an ad-hoc network amongst flying platforms (e.g. commercial aircraft, satellites, high altitude platforms) incorporating free-space optical communication links has been developed. This paper presents an algorithm for a decentralized collaborative decision-making process for building the topology of this mobile ad-hoc network. The design, the implementation in an agent-based modelling tool, and the evaluation of this so-called ConOps Agent algorithm using real flight data are described.
Occurrence of enteric viruses and faecal indicators in submarine groundwater discharges in the coastal environment of the Mexican Caribbean

The occurrence of faecal microorganisms such as total coliforms (TCs), Escherichia coli (E. coli), coliphages (somatic and F+ specific) and the genomes of faecal viruses: human adenovirus (HAdV), norovirus (NoV) genogroup I (GI) and II (GII), enterovirus (EV), aichi virus (AiV) and Pepper mild mottle virus (PMMoV), was explored in submarine groundwater discharges (SGDs) in the Mexican Caribbean. Ultra‐filtrated water samples were subjected to nucleic acid extraction and real‐time quantitative polymerase chain reaction (PCR). Results showed the presence of TC bacteria at all sites, whereas the detection of E. coli occurred only during the dry season. Coliphages occurred during the rainy and dry seasons, with concentrations ranging from 10 to 2560 plaque forming units (PFU/100 ml). HAdV and AiV were detected in 50% and 41% of the samples, at concentrations ranging from 102 to 104 genome copies per litre (GC/L) and from 102 to 106 GC/L, respectively. NoV GI and II were detected in 25% and 16% of the samples, at concentrations of 101 GC/L and 102–103 GC/L, respectively. PMMoV was detected in 50% of the samples at concentrations ranging from 101 to 103 GC/L. The EV genomes were not detected. These findings demonstrate that faecal microorganisms can be transported through SGDs in the Mexican Caribbean, potentially contributing to human health risks for recreation.
Novel sliding valley current mode pulse train control for switching DC-DC converter

ABSTRACT Multi valley current mode pulse train (MVC-PT) control technology can completely eliminate the low-frequency oscillation phenomenon of DC-DC switching converters operated in continuous conduction mode (CCM). However, this method needs to increase the number of preset value to broaden the output power range, which will increase the complexity and cost of the controller, and reduce the robustness of the system. Meanwhile, the output voltage ripple is uncontrollable and varied with the changes of the load. In this paper, a novel sliding valley current mode PT (SVC-PT) control technique is proposed to solve the above-mentioned problem. The SVC-PT operating principle and the deficiency of MVC-PT method are analysed in details. The approximate discrete-time models of SVC-PT and MVC-PT controlled switching DC-DC converters are constructed and compared. The comparison results verify that the proposed control method can thoroughly lessen the restriction of the controller on the output power range. Moreover, the control circuit is simplified and the output voltage ripple can be controlled. Finally, the simulation and experimental results are present to prove the feasibility and scientific of SVC-PT control technology.
Extrinsic Camera Calibration From a Moving Person

We propose a novel camera calibration method for a room-scale multi-view imaging system. Our key idea is to leverage our articulated body movements as a calibration target. We show that a freely moving person provides trajectories of a set of oriented points (e.g., neck joint with spine direction) from which we can estimate the locations and poses of all cameras observing them. The method only requires the cameras to be synced and that 2D human poses are estimated in each view sequence. By elevating these 2D poses to 3D which directly provides a set of oriented 3D joints, we compute the extrinsic parameters of all cameras with a linear algorithm. We also show that this enables self-supervision of the 3D joint estimator for refinement, and the iteration of the two leads to accurate camera extrinsics and 3D pose estimates up to scale. Extensive experiments using synthetic and real data demonstrate the effectiveness and flexibility of the method. The method will serve as a useful tool to expand the utility of multi-view vision systems as it eliminates the need for cumbersome on-site calibration procedures.
Time to DTR: fan paratextualization about Game of Thrones last season

Purpose: Media products meaning lies on the interpretation of its content. As productive consumers, fans reframe them. In the process, they produce new texts on these products, known as paratexts. The research aims to understand how fan’s paratexts (re)produces discourses to re-signify media products’ (para)texts. For such, we look at fan paratextualization of Game of Thrones (GoT), an economic and cultural phenomenon with huge repercussions on social media. Design/methodology/approach: Through a Foucauldian Archeology, we collected and analyzed comments posted by GoT fans on promotional videos published on the TV series' official YouTube channel. Findings: The fans' paratextual production presents different positions on the consumed cultural product: a public tribute highlighting its cultural legacy that is based on feelings of nostalgia and frustration with the conclusion of its plot. We conclude that these paratexts worked as a reckoning for the TV series’ fans. Broadly, it is possible to interpret paratexts as marketing content that allow fans to act as prosumers of media products, the entertainment industry, and fans' culture. Originality/value: The study presents how the fans’ productive consumption is materialized through the paratext (re)production that both establish the resonance of media objects in the culture of fans and lead them to assume the role of co-authors of the texts they consume. This role reinforces how fans should be understood as consumers who can act freely in relation to marketing actions. Moreover, it implies that paratexts can be produced to stimulate the discursive production that works as prosumer performance of fans.
Light-Induced Activation of a Specific Type-5 Metabotropic Glutamate Receptor Antagonist in the Ventrobasal Thalamus Causes Analgesia in a Mouse Model of Breakthrough Cancer Pain

Breakthrough cancer pain (BTcP) refers to a sudden and transient exacerbation of pain, which develops in patients treated with opioid analgesics. Fast-onset analgesia is required for the treatment of BTcP. Light-activated drugs offer a novel potential strategy for the rapid control of pain without the typical adverse effects of systemic analgesic drugs. mGlu5 metabotropic glutamate receptor antagonists display potent analgesic activity, and light-induced activation of one of these compounds (JF-NP-26) in the thalamus was found to induce analgesia in models of inflammatory and neuropathic pain. We used an established mouse model of BTcP based on the injection of cancer cells into the femur, followed, 16 days later, by systemic administration of morphine. BTcP was induced by injection of endothelin-1 (ET-1) into the tumor, 20 min after morphine administration. Mice were implanted with optic fibers delivering light in the visible spectrum (405 nm) in the thalamus or prelimbic cortex to locally activate systemically injected JF-NP-26. Light delivery in the thalamus caused rapid and substantial analgesia, and this effect was specific because light delivery in the prelimbic cortex did not relieve BTcP. This finding lays the groundwork for the use of optopharmacology in the treatment of BTcP.
Finite-time Motion Planning of Multi-agent Systems with Collision Avoidance

Finite-time motion planning with collision avoidance is a challenging issue in multi-agent systems. This paper proposes a novel distributed controller based on a new Lyapunov barrier function which guarantees finite-time stability for multi-agent systems without collisions. First, the problem of finite-time motion planning of multi-agent systems is formulated. Then, a novel finite-time distributed controller is developed based on a Lyapunov barrier function. Finally, numerical simulations demonstrate the effectiveness of proposed method.
A Multifunctional Hybrid Frequency-Selective Rasorber With a High-Efficiency Cross-Polarized Passband/Co-Polarized Specular Reflection Band

A novel multifunctional hybrid frequency-selective rasorber (MHFSR) which shows a broadband high-efficiency cross-polarized passband/co-polarized specular reflection band besides a wideband radar cross section (RCS) reduction is designed and analyzed. The passband/reflection band is realized by the bottom transmissive polarization converter (TPC) which exhibits a broadband cross-polarized transmission window for the <inline-formula> <tex-math notation="LaTeX">$x$ </tex-math></inline-formula>-polarized incidence and a co-polarized specular reflection window for the <inline-formula> <tex-math notation="LaTeX">$y$ </tex-math></inline-formula>-polarized incidence. The design methodology and four-port equivalent circuit model (ECM) are proposed and investigated. By arranging the top layer in the checkerboard-like distribution, the −1 dB cross-polarized transmission band is 9.5–11.7 GHz, and the 10 dB monostatic RCS reduction band is 2.8–20 GHz with a 151% fractional bandwidth (FBW) for the <inline-formula> <tex-math notation="LaTeX">$x$ </tex-math></inline-formula>-polarized incidence. While for the <inline-formula> <tex-math notation="LaTeX">$y$ </tex-math></inline-formula>-polarized incidence, two 10 dB monostatic RCS reduction bands locate at 3.3–8.5 and 15–20 GHz, and the middle −1 dB co-polarized reflection bands locate at 10–11.5 GHz. Meanwhile, the periodicity of the proposed MHFSR is only <inline-formula> <tex-math notation="LaTeX">$0{. }07\lambda _{L} $ </tex-math></inline-formula>, <inline-formula> <tex-math notation="LaTeX">$\lambda _{L} $ </tex-math></inline-formula> is the free-space wavelength at the lowest working frequency (2.8 GHz). The experimental results of the fabricated sample agree with the simulation results well, which proves the design validity. The proposed design combines the design of FSR, diffusion-like metasurface, and TPC to present an extra cross-polarized passband/co-reflection band besides the ultrabroadband RCS reduction.
Nuclear Transport of Respiratory Syncytial Virus Matrix Protein Is Regulated by Dual Phosphorylation Sites

Respiratory syncytial virus (RSV) is a major cause of respiratory infections in infants and the elderly. Although the RSV matrix (M) protein has key roles in the nucleus early in infection, and in the cytoplasm later, the molecular basis of switching between the nuclear and cytoplasmic compartments is not known. Here, we show that protein kinase CK2 can regulate M nucleocytoplasmic distribution, whereby inhibition of CK2 using the specific inhibitor 4,5,6,7-tetrabromobenzo-triazole (TBB) increases M nuclear accumulation in infected cells as well as when ectopically expressed in transfected cells. We use truncation/mutagenic analysis for the first time to show that serine (S) 95 and threonine (T) 205 are key CK2 sites that regulate M nuclear localization. Dual alanine (A)-substitution to prevent phosphorylation abolished TBB- enhancement of nuclear accumulation, while aspartic acid (D) substitution to mimic phosphorylation at S95 increased nuclear accumulation. D95 also induced cytoplasmic aggregate formation, implying that a negative charge at S95 may modulate M oligomerization. A95/205 substitution in recombinant RSV resulted in reduced virus production compared with wild type, with D95/205 substitution resulting in an even greater level of attenuation. Our data support a model where unphosphorylated M is imported into the nucleus, followed by phosphorylation of T205 and S95 later in infection to facilitate nuclear export and cytoplasmic retention of M, respectively, as well as oligomerization/virus budding. In the absence of widely available, efficacious treatments to protect against RSV, the results raise the possibility of antiviral strategies targeted at CK2.
A Review on the Application of Knowledge Graph Technology in the Medical Field

With the continuous development of Internet technology, knowledge graph construction has received increasing attention. Extracting useful medical knowledge from massive data is the key to analyzing big medical data. The knowledge graph is a semantic network that reveals relationships between entities. Medicine is one of the widely used fields of knowledge graphs, and the construction of a medical knowledge graph is also a research hotspot in artificial intelligence. Knowledge graph technology has broad application prospects in the field. First, this study comprehensively analyzes the structure and construction technology of the medical knowledge graph according to the characteristics of big data in the medical field, such as strong professionalism and complex structure. Second, this study summarizes the key technologies and research progress of the four modules of the medical knowledge graph: knowledge representation, knowledge extraction, knowledge fusion, and knowledge reasoning. Finally, with the major challenges and key problems of the current medical knowledge graph construction technology, its development prospects are prospects.
Metasurface-Loaded Off-Center Monopoles With Wideband Radiation Performance Using Characteristic Mode Analysis

A metasurface (MTS)-based reactive impedance surface (RIS) is proposed to load an eccentrically placed monopole above a ground plane for controllable wideband omnidirectional radiation. With the off-center placement, the radiation pattern of the monopole is not omnidirectional anymore, with ripples in the H-plane measured by un-roundness. The RIS is introduced above and in parallel with the finite ground plane and the monopole is placed in the center of the RIS. Characteristic mode analysis (CMA) is used to analyze the RIS-loaded monopole and to reveal the mechanism. It is found that two desired modes determine the bandwidth of the omnidirectional radiation together. The resonant frequency of the RIS mode can be easily tuned by changing the sheet impedance of the RIS. A metal-dielectric-metal constructed MTS is proposed to realize the RIS. The grid impedance of the MTS can be tuned easily by changing the size of the patch in the unit cell. For a single monopole placed off-center above a rectangular ground plane (150 mm <inline-formula> <tex-math notation="LaTeX">$\times300$ </tex-math></inline-formula> mm), the impedance bandwidth is increased from 19.6% to 32.4% with <inline-formula> <tex-math notation="LaTeX">$\vert \text{S}_{11}\vert < -10$ </tex-math></inline-formula> dB at <inline-formula> <tex-math notation="LaTeX">$f_{0} =2.5$ </tex-math></inline-formula> GHz. And the maximum un-roundness is reduced by 66.7% from 4.8 to 1.6 dB over the frequency band of 2.2–2.8 GHz. For a two-monopole antenna system with the same ground plane mentioned above, the loading MTS increases the impedance bandwidth of the monopole from 19.2% to 32.4% with <inline-formula> <tex-math notation="LaTeX">$\vert \text{S}_{11}\vert < -10$ </tex-math></inline-formula> dB at <inline-formula> <tex-math notation="LaTeX">$f_{0} =2.5$ </tex-math></inline-formula> GHz. When only one monopole is loaded with MTS in the system, the maximum un-roundness is reduced by 65.5% from 5.5 to 1.9 dB in the frequency band of 2.2–2.8 GHz. When both monopoles are loaded with MTS in the system, the maximum un-roundness is reduced by 40% from 5.5 to 3.3 dB in the frequency band of 2.2–2.8 GHz. The antenna prototypes are fabricated and measured.
Role of Oxidative Stress in the Pathogenesis of Atherothrombotic Diseases

Oxidative stress is generated by the imbalance between reactive oxygen species (ROS) formation and antioxidant scavenger system’s activity. Increased ROS, such as superoxide anion, hydrogen peroxide, hydroxyl radical and peroxynitrite, likely contribute to the development and complications of atherosclerotic cardiovascular diseases (ASCVD). In genetically modified mouse models of atherosclerosis, the overexpression of ROS-generating enzymes and uncontrolled ROS formation appear to be associated with accelerated atherosclerosis. Conversely, the overexpression of ROS scavenger systems reduces or stabilizes atherosclerotic lesions, depending on the genetic background of the mouse model. In humans, higher levels of circulating biomarkers derived from the oxidation of lipids (8-epi-prostaglandin F2α, and malondialdehyde), as well as proteins (oxidized low-density lipoprotein, nitrotyrosine, protein carbonyls, advanced glycation end-products), are increased in conditions of high cardiovascular risk or overt ASCVD, and some oxidation biomarkers have been reported as independent predictors of ASCVD in large observational cohorts. In animal models, antioxidant supplementation with melatonin, resveratrol, Vitamin E, stevioside, acacetin and n-polyunsaturated fatty acids reduced ROS and attenuated atherosclerotic lesions. However, in humans, evidence from large, placebo-controlled, randomized trials or prospective studies failed to show any athero-protective effect of antioxidant supplementation with different compounds in different CV settings. However, the chronic consumption of diets known to be rich in antioxidant compounds (e.g., Mediterranean and high-fish diet), has shown to reduce ASCVD over decades. Future studies are needed to fill the gap between the data and targets derived from studies in animals and their pathogenetic and therapeutic significance in human ASCVD.