Miracle-dz/UniFAR-FTUs huggingface dataset:
Physiotherapy modalities used in the management of chronic low back pain

Chronic low back pain (CLBP) is a costly andcommon medical problem accounting for 75-90% of compensationcosts as a result of repeated treatments, long term work absenteeismand social support-unemployment compensation. Physiotherapytreatment modalities are commonly used in the management ofCLBP. Data on the management of CLBP by physiotherapists inlow income countries are scarce.A cross-sectional survey was used to investigate the managementof CLBP by physiotherapists in Kwazulu-Natal (KZN). Theobjectives of the study were to establish: the commonly used physiotherapymodalities; reasons; and the evidence base used for their choice. Six hundred and eighty-five self-administeredquestionnaires were posted to all registered physiotherapists in KZN.Of 213 returned questionnaires, 141 (20.6%) met the inclusion criteria as they managed patients with CLBP.General exercises (30%); spinal mobilisation (28%); myofascial release (18%), education (12%) and training oflocal stabilisers(12%) were the commonly used treatment modalities. Key reasons for the selection of the treatmentmodalities were undergraduate education received; own clinical experience and the attendance of postgraduate courses/physiotherapy conferences.From the reasons specified for the selection of treatment modalities, the use of written current available literaturethrough reading of journal articles was sparsely utilized.
Homodimericin A: A Complex Hexacyclic Fungal Metabolite

Microbes sense and respond to their environment with small molecules, and discovering these molecules and identifying their functions informs chemistry, biology, and medicine. As part of a study of molecular exchanges between termite-associated actinobacteria and pathogenic fungi, we uncovered a remarkable fungal metabolite, homodimericin A, which is strongly upregulated by the bacterial metabolite bafilomycin C1. Homodimericin A is a hexacyclic polyketide with a carbon backbone containing eight contiguous stereogenic carbons in a C20 hexacyclic core. Only half of its carbon atoms have an attached hydrogen, which presented a significant challenge for NMR-based structural analysis. In spite of its microbial production and rich stereochemistry, homodimericin A occurs naturally as a racemic mixture. A plausible nonenzymatic reaction cascade leading from two identical achiral monomers to homodimericin A is presented, and homodimericin A’s formation by this path, a six-electron oxidation, could be a response to oxidative stress triggered by bafilomycin C1.
Comparative feeding kinematics of tropical hylid tadpoles

SUMMARY Anuran larvae, which are otherwise simple in shape, typically have complex keratinized mouthparts (i.e. labial teeth and jaw sheaths) that allow them to graze upon surfaces. The diversity in these structures among species presumably reflects specializations that allow for maximal feeding efficiency on different types of food. However, we lack a general understanding of how these oral structures function during feeding. We used high-speed digital imaging (500 Hz) to observe tadpoles of six species from the anuran family Hylidae grazing on a standardized food-covered substrate. Tadpoles of these species vary in the number of labial tooth rows, belong to two different feeding guilds (benthic and nektonic), and inhabit ponds and streams. We confirmed that the labial teeth in these species serve two functions: anchoring the mouth to the substrate and raking material off of the substrate. In general, tadpoles with a larger maximum gape or those with fewer labial tooth rows opened and closed their mouths slower than tadpoles with smaller gape or more tooth rows. Nektonic feeding tadpoles released each of their tooth rows proportionally earlier in the gape cycle compared with benthic feeding tadpoles. Lastly, we found some support for the idea that deformation of the jaw sheaths during a feeding cycle is predictable based on tadpole feeding guild. Collectively, our data show that anatomical (e.g. number of labial teeth) and ecological features (e.g. feeding guild) of tadpoles significantly influence how tadpoles open and close their mouths during feeding.
Scalable and efficient provable data possession

Storage outsourcing is a rising trend which prompts a number of interesting security issues, many of which have been extensively investigated in the past. However, Provable Data Possession (PDP) is a topic that has only recently appeared in the research literature. The main issue is how to frequently, efficiently and securely verify that a storage server is faithfully storing its client's (potentially very large) outsourced data. The storage server is assumed to be untrusted in terms of both security and reliability. (In other words, it might maliciously or accidentally erase hosted data; it might also relegate it to slow or off-line storage.) The problem is exacerbated by the client being a small computing device with limited resources. Prior work has addressed this problem using either public key cryptography or requiring the client to outsource its data in encrypted form. In this paper, we construct a highly efficient and provably secure PDP technique based entirely on symmetric key cryptography, while not requiring any bulk encryption. Also, in contrast with its predecessors, our PDP technique allows outsourcing of dynamic data, i.e, it efficiently supports operations, such as block modification, deletion and append.
Role of the iridescent eye in stickleback female mate choice

SUMMARY Many vertebrates exhibit prominent body colours that are used in courtship and territorial communication. Some fishes also have an eye whose iris becomes iridescent during the mating season, as in the threespine stickleback. Behavioural studies in this species have focused on the redness of the throat/jaw as the primary determinant of female mate choice. Unlike the iridescent eye, however, the red throat/jaw is not present in all stickleback populations, suggesting that the colour of the eye may be equally important for female mate choice. Here, we used data on photoreceptors and environmental light to assess body conspicuousness and the colour contrast of courtship signals for stickleback populations living in a range of waters, from clear (mesotrophic) to red light shifted (dystrophic). This analysis indicated that the redness of the throat/jaw is expressed to enhance the contrast of the eye. To test the importance of eye colour as a courtship signal, we carried out mate choice experiments in which females were presented with identical videos of a courting male but for the colour of the eye and/or the throat/jaw. Females did not choose based on differences in throat/jaw redness between videos, but preferred males with the highest contrast between the eye and the throat/jaw. This result points to the blue iridescent eye as a primary courtship signal in stickleback female mate choice.
The evolution of endothermy is explained by thyroid hormone-mediated responses to cold in early vertebrates

The evolution of endothermy is one of the most intriguing and consistently debated topics in vertebrate biology, but the proximate mechanisms that mediated its evolution are unknown. Here, we suggest that the function of thyroid hormone in regulating physiological processes in response to cold is key to understanding the evolution of endothermy. We argue that the capacity of early chordates to produce thyroid hormone internally was the first step in this evolutionary process. Selection could then act on the capacity of thyroid hormone to regulate metabolism, muscle force production and cardiac performance to maintain their function against the negative thermodynamic effects of decreasing temperature. Thyroid-mediated cold acclimation would have been the principal selective advantage. The actions of thyroid hormone during cold acclimation in zebrafish are very similar to its role during endothermic thermogenesis. The thyroid-mediated increases in metabolism and locomotor performance in ectotherms eventually resulted in sufficient heat production to affect body temperature. From this point onwards, increased body temperature per se could be of selective advantage and reinforce thyroid-induced increases in physiological rates. Selection for increased body temperature would promote those mechanisms that maximise heat production, such as increased Na+/K+-ATPase activity, futile cycling by SERCA, and mitochondrial uncoupling, all of which are regulated by thyroid hormone. The specific end point of this broader evolutionary process would be endothermic thermoregulation. However, considering the evolution of endothermy in isolation is misleading because the selective advantages that drove the evolutionary process were independent from endothermy. In other words, without the selective advantages of thyroid-mediated cold acclimation in fish, there would be no endotherms.
Growing Old in a Foreign Context — Older Immigrants' Experience of Everyday Life in Residential Care Facilities

Aim: The aim of the study was to illuminate older immigrants' experiences of moving to a residential care facility. Background: Increased immigration will lead to a future increase in the number of older immigrants in residential care. In order to adjust nursing care to their needs it is important to acquire knowledge of their situation. Methods: Semi-structured interviews with seven immigrants living in residential care in Sweden were analysed using a qualitative manifest content analysis. Findings: Older immigrants' experience of everyday life in residential care facilities was: Trying to adjust to relocation to residential care, Feeling alienated by communication difficulties, and Trying to stay connected by keeping ties to the origin and past, with internal variation seen as subcategories. Conclusion: Older immigrants, who move into residential care are vulnerable and experience a major transition as they move from a familiar social and cultural environment into a place mainly designed for older Swedes. There is a great risk that they will become alienated and highly dependent on their relatives if not nursing care interventions with specific focus on their needs are developed.
Sorting networks and their applications

To achieve high throughput rates today's computers perform several operations simultaneously. Not only are I/O operations performed concurrently with computing, but also, in multiprocessors, several computing operations are done concurrently. A major problem in the design of such a computing system is the connecting together of the various parts of the system (the I/O devices, memories, processing units, etc.) in such a way that all the required data transfers can be accommodated. One common scheme is a high-speed bus which is time-shared by the various parts; speed of available hardware limits this scheme. Another scheme is a cross-bar switch or matrix; limiting factors here are the amount of hardware (an m × n matrix requires m × n cross-points) and the fan-in and fan-out of the hardware.
Exploring the effect of specific packed cell volume upon bloodstain pattern analysis: blood drying and dry volume estimation

Abstract Bloodstain Pattern Analysis (BPA) involves the interpretation of distinct blood patterns found at crime scenes after a bloodletting incident. Much time and research has been dedicated to the quantification and analysis of blood due to its occurrence at crime scenes, establishing ways in which to map the sequence of events and general movement within the crime scene. In this paper we explore the fundamental mechanism of drying blood and the effects of packed cell volume percentage (PCV%) upon BPA investigations. Since PCV% can fluctuate between 15–75%, and in turn directly affect blood viscosity, it is important to consider its impact when evaluating bloodstains. Specific packed cell volumes (PCV%) between 15 and 75% were investigated, relating to the highest and lowest levels found in potential victims or suspects. Observations illustrated the appearance of the “coffee-ring” effect as an important mechanism of drying blood, building a thicker outer ring of red blood cells as the drop evaporates and dries, the so-called the blood ring effect. There was also found to be a significant difference in the appearance of the final bloodstains when comparing PCV%. Owing to the lower PCV% being made up of mainly plasma, bloodstains became more transparent under microscopic observation. The opposite conclusions can be made for higher PCVs where bloodstains were much thicker around the periphery of the stain. Crime scene relatable drying studies were also considered; skeletonization (relating to drying time) and volume estimation were all investigated in relation to PCV%. Three volume estimation studies were performed: dry weight, scaled photographs and spectrophotometry. It was found that all were unsuitable for volume estimation, when considering PCV% and surface type. Since PCV% cannot be established in dried blood, these volume estimation methods should not be used as the errors would be too great. Skeletonization (drying time) was not altered by PCV%.
Multiple Converged Conduction Bands in K2Bi8Se13: A Promising Thermoelectric Material with Extremely Low Thermal Conductivity.

We report that K2Bi8Se13 exhibits multiple conduction bands that lie close in energy and can be activated through doping, leading to a highly enhanced Seebeck coefficient and a high power factor with elevated temperature. Meanwhile, the large unit cell, complex low symmetry crystal structure, and nondirectional bonding lead to the very low lattice thermal conductivity of K2Bi8Se13, ranging between 0.42 and 0.20 W m-1 K-1 in the temperature interval 300-873 K. Experimentally, we further support the low thermal conductivity of K2Bi8Se13 using phonon velocity measurements; the results show a low average phonon velocity (1605 ms-1), small Young's modulus (37.1 GPa), large Grüneisen parameter (1.71), and low Debye temperature (154 K). A detailed investigation of the microstructure and defects was carried out using electron diffraction and transmission microscopy which reveal the presence of a K2.5Bi8. 5Se14 minor phase intergrown along the side of the K2Bi8Se13 phase. The combination of enhanced power factor and low thermal conductivity results in a high ZT value of ∼1.3 at 873 K in electron doped K2Bi8Se13 material.
Amphibious hearing in spotted seals (Phoca largha): underwater audiograms, aerial audiograms and critical ratio measurements

Spotted seals (Phoca largha) inhabit Arctic regions that are facing both rapid climate change and increasing industrialization. While little is known about their sensory capabilities, available knowledge suggests that spotted seals and other ice seals use sound to obtain information from the surrounding environment. To quantitatively assess their auditory capabilities, the hearing of two young spotted seals was tested using a psychophysical paradigm. Absolute detection thresholds for tonal sounds were measured in air and under water over the frequency range of hearing, and critical ratios were determined using octave-band masking noise in both media. The behavioral audiograms show a range of best sensitivity spanning four octaves in air, from approximately 0.6 to 11 kHz. The range of sensitive hearing extends across seven octaves in water, with lowest thresholds between 0.3 and 56 kHz. Critical ratio measurements were similar in air and water and increased monotonically from 12 dB at 0.1 kHz to 30 dB at 25.6 kHz, indicating that the auditory systems of these seals are quite efficient at extracting signals from background noise. This study demonstrates that spotted seals possess sound reception capabilities different from those previously described for ice seals, and more similar to those reported for harbor seals (Phoca vitulina). The results are consistent with the amphibious lifestyle of these seals and their apparent reliance on sound. The hearing data reported herein are the first available for spotted seals and can inform best management practices for this vulnerable species in a changing Arctic.
The cost of muscle power production: muscle oxygen consumption per unit work increases at low temperatures in Xenopus laevis

Metabolic energy (ATP) supply to muscle is essential to support activity and behaviour. It is expected, therefore, that there is strong selection to maximise muscle power output for a given rate of ATP use. However, the viscosity and stiffness of muscle increases with a decrease in temperature, which means that more ATP may be required to achieve a given work output. Here, we tested the hypothesis that ATP use increases at lower temperatures for a given power output in Xenopus laevis. To account for temperature variation at different time scales, we considered the interaction between acclimation for 4 weeks (to 15 or 25°C) and acute exposure to these temperatures. Cold-acclimated frogs had greater sprint speed at 15°C than warm-acclimated animals. However, acclimation temperature did not affect isolated gastrocnemius muscle biomechanics. Isolated muscle produced greater tetanus force, and faster isometric force generation and relaxation, and generated more work loop power at 25°C than at 15°C acute test temperature. Oxygen consumption of isolated muscle at rest did not change with test temperature, but oxygen consumption while muscle was performing work was significantly higher at 15°C than at 25°C, regardless of acclimation conditions. Muscle therefore consumed significantly more oxygen at 15°C for a given work output than at 25°C, and plastic responses did not modify this thermodynamic effect. The metabolic cost of muscle performance and activity therefore increased with a decrease in temperature. To maintain activity across a range of temperature, animals must increase ATP production or face an allocation trade-off at lower temperatures. Our data demonstrate the potential energetic benefits of warming up muscle before activity, which is seen in diverse groups of animals such as bees, which warm flight muscle before take-off, and humans performing warm ups before exercise.
Force Coordination in Object Manipulation

Force Coordination in Object Manipulation Purpose: The purpose of this review is to present our recent findings related to the studies of hand function based on the coordination of forces exerted against hand-held objects. Basic procedures: A novel device has been developed for recording grip (GF; acting perpendicularly at the hand-object contact) and load force (LF; acting tangentially) during uni- and bimanual manipulation tasks performed under either static or dynamic conditions. Both healthy participants and neurological patients were tested. The outcome measures were obtained from the task performance (i.e., the ability to exert accurate LF profiles), GF-LF coordination and GF modulation. Main findings: The method applied proved to not only to be both reliable and valid, but also sufficient to detect differences between the dominant and non-dominant hand, as well as between healthy participants and mildly involved neurological patients. Marked differences in most of the depended variables were also detected between unidirectional and bi-direction tasks (i.e., in the tasks where LF acts in one and in two alternating directions). The later finding could not be based neural mechanisms known for their role in manipulative actions, such as on employing ad hoc muscle synergies or on the afferent activity of skin mechanoreceptors. Conclusions: The employed methodological approach can be applied not only to explore various manipulation activities, but also to serve as a basis for future development of specific clinical tests for populations that demonstrate impaired hand function.
The role of egg–nest contrast in the rejection of brood parasitic eggs

ABSTRACT Hosts of avian brood parasites can avoid the reproductive costs of raising genetically unrelated offspring by rejecting parasitic eggs. The perceptual cues and controls mediating parasitic egg discrimination and ejection are well studied: hosts are thought to use differences in egg color, brightness, maculation, size and shape to discriminate between their own and foreign eggs. Most theories of brood parasitism implicitly assume that the primary criteria to which hosts attend when discriminating eggs are differences between the eggs themselves. However, this assumption is confounded by the degree to which chromatic and achromatic characteristics of the nest lining co-vary with egg coloration, so that egg–nest contrast per se might be the recognition cue driving parasitic egg detection. Here, we systematically tested whether and how egg–nest contrast itself contributes to foreign egg discrimination. In an artificial parasitism experiment, we independently manipulated egg color and nest lining color of the egg-ejector American robin (Turdus migratorius), a host of the obligate brood parasitic brown-headed cowbird (Molothrus ater). We hypothesized that the degree of contrast between foreign eggs and the nest background would affect host egg rejection behavior. We predicted that experimentally decreasing egg–nest chromatic and achromatic contrast (i.e. rendering parasitic eggs more cryptic against the nest lining) would decrease rejection rates, while increasing egg–nest contrast would increase rejection rates. In contrast to our predictions, egg–nest contrast was not a significant predictor of egg ejection patterns. Instead, egg color significantly predicted responses to parasitism. We conclude that egg–egg differences are the primary drivers of egg rejection in this system. Future studies should test for the effects of egg–nest contrast per se in predicting parasitic egg recognition in other host–parasite systems, including those hosts building enclosed nests and those parasites laying cryptic eggs, as an alternative to hypothesized effects of egg–egg contrast. Summary: We tested whether and how egg–nest visual contrast contributes to parasitic egg discrimination in American robins. We found no effect of egg–nest contrast on egg rejection rates, and conclude that egg–egg contrasts are the primary drivers of egg rejection in this system.
Reduce torques and stick the landing: limb posture during landing in toads

A controlled landing, where an animal does not crash or topple, requires enough stability to allow muscles to effectively dissipate mechanical energy. Toads (Rhinella marina) are exemplary models for understanding the mechanics and motor control of landing given their ability to land consistently during bouts of continuous hopping. Previous studies in anurans have shown that ground reaction forces (GRFs) during landing are significantly higher compared with takeoff and can potentially impart large torques about the center of mass (COM), destabilizing the body at impact. We predict that in order to minimize such torques, toads will align their COM with the GRF vector during the aerial phase in anticipation of impact. We combined high-speed videography and force-plate ergometry to quantify torques at the COM and relate the magnitude of torques to limb posture at impact. We show that modulation of hindlimb posture can shift the position of the COM by about 20% of snout–vent length. Rapid hindlimb flexion during the aerial phase of a hop moved the COM anteriorly and reduced torque by aligning the COM with the GRF vector. We found that the addition of extrinsic loads did not significantly alter landing behavior but did change the torques experienced at impact. We conclude that anticipatory hindlimb flexion during the aerial phase of a hop is a critical feature of a mechanically stable landing that allows toads to quickly string together multiple, continuous hops.