Miracle-dz/UniFAR-FTUs huggingface dataset:
Nursing Student Work-Study Internship: Partnering to Bridge the Education-to-Practice Gap

Discussed for decades, the need for transitional ex periences bridging educational and practice settings gained momentum in the mid-1970s with the rel ase of Kramer’s groundbreaking book Reality Shock: Why Nurses Leave Nursing . Nursing student internship programs were develope d in the 1970s as one effort to address this issue. T h Northern California Region of Kaiser Permanente partners with five universities to condu ct the Nursing Student Work-Study Internship Program (WSP). The program provides seni or level nursing students with a paid internship in clinical practice settings, working u nder the supervision of RN preceptors. The aim of the program is to improve the intern’s perceptio n of readiness for practice as professional RNs. An evidence-based, change of practice, quality improvement project was conducted to improve the organization’s existing Nursing Student WSP. Interventions included an evaluation of the WSP structure, processes, and outcomes, and development of evidence-based resources to address identified gaps. The 2008 Casey Fink Readiness for Practice Survey© was administered to the 2016 cohort prior to and at the conclusion o f the internship as a measure of the WSP impact on intern’s progression toward professional pr ctice and demonstration of value to the organization. Quality improvement measures had a po sitive impact on nursing student interns and demonstrated program value to the organization.
Novel Sacrificial Medicinal Repositories: Halfa grass, Desmostachya bipinnata (L.) and Cogon grass, Imperata cylindrica (L.)

Grasses are the most successful plants on earth as monocotyledonous plants. They have been a survivor on the planet despite of various ecological changes. They deserve the medicinal value and therefore considered as novel repositories. The grass family is considered as sacred. It has great significance in ayurveda because of medicinal as well as clinical properties. The Desmostachya bipinnata (L.) (commonly recognized as halfa grass, big cordgrass, and salt reed-grass) and Imperata cylindrica (L.) (commonly recognized as cogon grass, kunai grass, blady grass, alang-alang, lalang grass, cotton wool grass, kura-kura ) are the two grasses that constitute vital ingredient in various Vedic sacrifices (Yagnas) and rituals. These two grasses are found along river beds and plains throughout India. Both of them are well known for their medicinal properties as supported by traditional Ayurvedic scriptures. They are the vital component in traditional medicinal formulations such as Tripan chamool, Kusadya-ghrita and Kusablecha, that are used to treat many disorders such as dysentery, diuresis, jaundice, skin infections like disesses. The present attempt is current review enlightening the bioactive molecules such as flavonoids, glycosides isolated from these two grasses. World Scientific News 100 (2018) 35-50 -36The ecological monitoring is one of the essential strategy required for the conservation of biodiversity of the medicinal plants.
Time Evolution of Hurst Exponent: Czech Wholesale Electricity Market Study

In this paper we analyse a temporal evolution of the Hurst exponent estimated on hourly returns of intraday electricity prices in the Czech Republic in 2017 and 2018. Firstly we used the log-returns with adjustments due to negative values, and secondly we employed the returns based on the area hyperbolic sine transformation. We implemented a sliding window technique in order to estimate the Hurst exponent using the Detrended Fluctuation Analysis method on subsamples with four distinct window sizes. According to the stylised facts of electricity, the spot prices and their corresponding logarithmic returns should be mean-reverting. Since the Czech intraday electricity market remains mostly unexplored, we examined this phenomenon on the intraday rather than on the spot market. Consequently, our analysis showed that the estimated values of Hurst exponent indicate a mean-reverting process for time scales greater than 24 hours and a weakly mean-reverting process for the shorter time scales. There were a few exceptions, though, since our calculations have revealed the presence of a nearly random or even weakly persistent behaviour on the shorter time scales.
Genetic diversity and population structure of Fusarium fujikuroi causing Bakanae, an emerging disease of rice in India

Bakanae caused by Fusarium fujikuroi (Nirenberg), is emerging as a serious threat for rice (Oryza sativa. L.) cultivation in India. In this study, 63 isolates of Fusarium fujikuroi isolated from symptomatic diseased plants were characterized for their morphology, pathogenicity and molecular variability using universal rice primers (URP). Of the 12 URPs used in the study, 6 primers could produce polymorphic fragments in all the isolates. The URP 17R primer was highly polymorphic (100%), whereas, the URP 1F primer produced 75% polymorphic fragments. A dendrogram obtained from the combined analysis of 6 URP primers categorized the isolates into four clusters, where most of the isolates from Punjab and Haryana were clustered separately. Mating type of the population was identified based on MAT-1 and MAT-2 region universal primers for Gibberella fujikuroi. Among the 63 isolates, 18 (28.57%) were identified as MAT-1 and 45 (71.42%) as MAT-2. The effective population number for mating type was 89% of the total population. Since the distribution frequencies of both mating types were not equal in the Indian population of F. fujikuroi, it could conclude that majority of the multiplication of isolates under field conditions was through asexual reproduction. However, the presence of both mating types in F. fujikuroi indicates that the population is also capable of sexual reproduction. Therefore, it is important to develop cultivars with inbuilt resistance to bakanae disease, taking into consideration the factors such as environmental conditions and variability of the pathogen in the area of intended cultivation.
Study of the Compressive Strength of Mortars as a Function of Material Composition, Workability, and Specimen Geometry

In the present work, the statistical dispersion of the mortar compressive strength as a function of the geometric parameters of the specimens as well as the effect of the mortar workability difference on the compressive strength was investigated. For this purpose, specimens were prepared for six types of mortars: two conventional mortars in the proportions of 1 : 1 : 6 and 1 : 2 : 9 of cement, hydrated lime, and sand, respectively, two with clay replacing lime, and two with marble waste in place of lime. The results confirm the difference between the results found for the two geometries due to the differences in the heights of the molding layers and show that the workability of the mortar modifies the resistance properties, especially in the cylindrical mold where the molding of the specimens is more complex. By comparing the differences between the destructive test results and those defined by the Finite Element Modeling (FEM) for conventional mortars, it was clear that the effect of excess material in the sample during the compression tests did not change the strength properties studied. This facilitates the performance of the assay as specimens may be used excessively on the side without the need for sample rectification.
Prevalence and Risk Factors Associated with Type 2 Diabetes in Elderly Patients Aged 45-80 Years at Kanungu District

Background. Type 2 diabetes is a worldwide disaster including in Uganda, specifically in Kanungu District which had a rise in diabetic patients in 2018/2019 as compared to the 2017/2018 financial year. This research was determined to access the prevalence and risk factors associated with type 2 diabetes on elderly patients aged 45-80 years attending Kanungu Health Centre IV, Kanungu District. Methods. A cross-sectional study was conducted among patients aged 45-80 years attending Kanungu Health Centre IV from June to August 2019. The prevalence of type 2 diabetes was determined by the blood sugar of patients. Questionnaires were used to collect data for factors associated with type 2 diabetes. Data were statistically analyzed using the statistical package for social sciences (SPSS) version 25 (SPSS Inc., USA) at . Results. The overall prevalence of type 2 diabetes was 18.7% among the tested patients. 22.8% of diabetic patients were females as 7.8% were males. The age group most affected by diabetes was 61-65 years. Alcoholism, smoking, body mass index (BMI), and family history were found to be significantly associated with type 2 diabetes at value < 0.05. Conclusion. There was a high prevalence of type 2 diabetes observed in this study compared to studies done in previous years which raise a public health concern. This study also found that females and patients aged 61-65 years were most affected by diabetes. Lastly, the presence of family history for diabetes, overweight, and being obese increases the chances of acquiring type 2 diabetes.
Development of influenza vaccines in the face of pandemic threat

Het influenza virus is de verwekker van de griep en veroorzaakt in de wintermaanden epidemieen op het noordelijk halfrond. Sporadisch veroorzaakt het influenza virus een pandemie, waarbij het virus zich binnen korte tijd wereldwijd verspreidt met extra ziekte-en sterftegevaIIen tot gevoIg. Tijdens de 'Spaanse griep' pandemie van 1918 zijn naar schatting tussen 50 en 100 miljoen mensen omgekomen. Het ontstaan van een pandemie hangt samen met de introductie van een nieuw subtype influenza virus vanuit het dierenrijk in de menselijke populatie. Er bestaat dan nog geen immuniteit tegen dit nieuwe virus, waardoor het zich snel kan verspreiden. Het is onvoorspelbaar wanneer zo'n introductie plaats gaat vinden, en welk subtype influenza virus dit zal betreffen, maar dat het in de toekomst weer een keer gaat gebeuren is zeer waarschijnlijk. De uitbraken van het dodelijke H5N1 vogelgriep virus onder pluimvee in Zuidoost-Azie, waarbij ook mensen gelnfecteerd raakten, vormden een directe pandemische dreiging. De eerste uitbraak vond plaats in 1997. Sinds 2003 is het virus echter niet meer weggeweest en heeft zich in die tijd verspreid over meerdere continenten. De wereld gezondheidsorganisatie (WHO) hanteert nog steeds een verhoogde alarmfase, een stap onder het niveau waarbij overdraagbaarheid van mens naar mens gesignaleerd wordt. Tot nu overleed 60~, van de mensen met een bewezen H5N1 infectie. Als er een air-borne H5Nl virus ontstaat dat van mens naar mens overdraagbaar is -dit kan dotr mutaties van het virus of door vermenging (reassortment) met een menselijk influenza virus-kan dit tot een levensgevaarlijke pandemie lei den. Vaccinatie biedt de beste bescherming tegen infectie met het influenza virus. Echter, het ontwikkelen van een vaccin voor een eerstvolgende pandemie wordt bemoeilijkt door tal van zaken. Hieronder vallen de onzekerheid over de exacte identiteit (subtype) van het nieuwe pandemische virus, de onbekendheid van het tijdstip waarop de pandemie ontstaat, en de snelle wereldwijde verspreiding van het virus. Daamaast is de totale vaccin productiecapaciteit gelimiteerd en zijn de productiefaciliteiten gesitueerd in met name gei'ndustrialiseerde landen. Tijdens een pandemie kan daarom niet iedereen ter wereld tijdig over vaccins beschikken. Het vergroten van de beschikbaarheid van vaccins is dan ook een van de grote uitdagingen voor vaccinonderzoekers, In principe zouden door een verkleining van de benodigde dosis per vaccin, meer vaccindoses in dezelfde tijd geproduceerd kunnen worden,
A new combinatorial branch-and-bound algorithm for the Knapsack Problem with Conﬂict Graph

We study the Knapsack Problem with Conﬂict Graph (KPCG), a generalization of the Knap-sack Problem in which a conﬂict graph speciﬁes pairs of items (vertices of the graph) which cannot be simultaneously selected in a solution. The KPCG asks for determining a maximum-proﬁt subset of items of total weight no larger than the knapsack capacity which do not violate any of the item conﬂicts. In this work, we propose a novel combinatorial branch-and-bound algorithm for the KPCG based on an n -ary branching scheme. Our algorithm eﬀectively combines diﬀerent procedures for pruning the branch-and-bound nodes based on diﬀerent relaxations of the KPCG. Key to the algorithm is its high pruning potential and the low computational eﬀort that it requires to process each branch-and-bound node. An extensive set of experiments carried out on the benchmark instances typically used in the literature shows that, for edge densities ranging from 0.1 to 0.9, our algorithm is faster by up to two orders of magnitude than the state-of-the-art method and by up to several orders of magnitude than a state-of-the-art mixed-integer linear programming solver.
Comparing the Performance of ESL and English-Native Speaking Students in an Introductory Level Statistics Course

English as a second language (ESL) students often face more challenges than their English-Native Speaking (ENS) peers due to language and cultural barriers. The purpose of this study is to investigate the difference in performance between ESL students and ENS students in the introductory level statistics course, STAT150, at the University of Norther Colorado (UNC). Due to the dichotomous nature of the data and the large differences in sample sizes between ESN and ESL students, the Bootstrapped Logistic Regression model is used to analyze the data. Contrary to the findings of previously conducted studies, the results of this study suggest that ESL students who have been enrolled in STAT 150 at UNC are just as likely to receive a high mark in the course as their ENS counterparts. One explanation for this finding is that the level of instruction and quality of content provided throughout the course gave all students, including ESL students, all the information necessary to succeed in the course. If this explanation is accepted, the outcomecentric results found by this study reflect well upon the overall quality of instruction and English proficiency policies at UNC.
A Systematic Literature Review of Technology Acceptance Model and Theory of Planned Behaviour towards Online Learning Perspective

In recent years, due to the rapid development of the Internet, it has changed the national, social, economic, and cultural levels, and has become more involved in everyone’s daily life. We absorb information and knowledge through the Internet. The speed of knowledge innovation in modern society is extremely fast, and online learning has become increasingly popular. It can effectively cross the limits of time and space and provide people with new learning channels. Online learning has become the most important issue nowadays. This study is expected to collate and discuss the relevant research on the application of Technology Acceptance Model and Theory of Planned Behavior to online learning in the academic contribution. In terms of practical meaning, the period can give the government, educational institutions and universities and other institutions the development and promotion of specific recommendations for online learning, so that foreign language learners can learn online and enhance the competitiveness of employment and school. This study provides future research on the adoption and introduction of domestic online learning through the trend comparison of international journals, and calls on domestic researchers to focus on the scientific, institutional and historical context factors to enrich our online learning in the educational environment. In the future research direction, this study suggests that online learning requires multi-level, inter-connected analysis at different levels of individuals, organizations, and industries in future research.
The regulation of the human sphingosine 1-phosphate receptor, S1P 3

The S1P3 receptor is a member of the cell surface G-protein-coupled receptor superfamily (GPCR). S1P-mediated activation of the S1P3 receptor elicits an array of biological effects including angiogenesis, the process of new blood vessel formation, and may have an important role in atherosclerosis. After sustained exposure to agonist, many GPCRs undergo desensitisation, defined as the waning of receptor responsiveness in the face of persistent stimulation. The relative ability or inability of a GPCR to undergo classic agonist-mediated receptor phosphorylation and subsequent internalisation away from the cell surface is an important marker of GPCR desensitisation. This study has characterised, for the first time, the phosphorylation and internalisation of the human S1P3 receptor. Whole cell phosphorylation studies on hamster lung CCL-39 fibroblasts stably expressing human S1P3 receptors showed that S1P3 is phosphorylated in response to S1P in a time and concentration-dependent manner. In contrast activation of multiple 2nd messenger-activated kinases was without effect on S1P3 phosphorylation under the same conditions. It is well known that the C-terminal region of GPCRs often holds the primary site of interaction for receptor phosphorylation and interaction with β-arrestin. Engineering constructs that truncate the receptor by removing significant and potential sites of phosphorylation allowed the identification of a region bounded by residues Leu332 to Val352 as containing the sites of receptor phosphorylation. As GPCRs are known to be phosphorylated by GRKs a panel of GRKs were investigated, of these GRK2 appeared to phosphorylate the S1P3 receptor in vitro suggesting that GRK2 or a similar kinase is present during S1P3 phosphorylation. S1P3 receptor internalisation is not detectable in CCL-39 cells as determined by biotinylation assays. Also, sucrose density gradient experiments cound not detect a wholesale shift of receptor between lipid raft and non-lipid raft compartments after S1P exposure. Although, studies of S1P3 interaction with β-arrestin are currently preliminary, initial fundings from this research suggest that both receptor and arrestin co-localise after agonist stimulation. This hints at the possibility that internalisation may be obstructed by something other than interaction with arrestin and provokes a receptor-complex paradigm that involves both receptor, arrestin and another protein which is cell-type specific in order to allow internalisation. Experiments in HEK293 cells demonstrated that in this system, WT and phosphorylation resistant SIP3 receptors cound both internalise over identical time courses following agonist exposure. This suggests that SIP3 sensitivity to internalisation is regulated specifically depending on celltype and does not require receptor phosphorylation. This has implications in embryogenesis and also angiogenesis where cell growth and proliferation are vital to development of organs and vessels.
University of Groningen Conformation Effects of CpG Methylation on Single-Stranded DNA Oligonucleotides

Single-stranded DNA (ssDNA) is characterized by high conformational flexibility that allows these molecules to adopt a variety of conformations. Here we used native polyacrylamide gel electrophoresis (PAGE), circular dichroism (CD) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy to show that cytosine methylation at CpG sites affects the conformational flexibility of short ssDNA molecules. The CpG containing 37-nucleotide PDYN (prodynorphin) fragments were used as model molecules. The presence of secondary DNA structures was evident from differences in oligonucleotide mobilities on PAGE, from CD spectra, and from formation of A-T, G-C, and non-canonical G-T base pairs observed by NMR spectroscopy. The oligonucleotides displayed secondary structures at 4uC, and some also at 37uC. Methylation at CpG sites prompted sequence-dependent formation of novel conformations, or shifted the equilibrium between different existing ssDNA conformations. The effects of methylation on gel mobility and base pairing were comparable in strength to the effects induced by point mutations in the DNA sequences. The conformational effects of methylation may be relevant for epigenetic regulatory events in a chromatin context, including DNA-protein or DNA-DNA recognition in the course of gene transcription, and DNA replication and recombination when double-stranded DNA is unwinded to ssDNA. Citation: Taqi MM, Wärmländer SKTS, Yamskova O, Madani F, Bazov I, et al. (2012) Conformation Effects of CpG Methylation on Single-Stranded DNA Oligonucleotides: Analysis of the Opioid Peptide Dynorphin-Coding Sequences. PLoS ONE 7(6): e39605. doi:10.1371/journal.pone. 0039605 Editor: Maria Gasset, Consejo Superior de Investigaciones Cientificas, Spain Received February 8, 2012; Accepted May 23, 2012; Published June 29, 2012 Copyright: 2012 Taqi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This work was supported by grants from the Swedish Science Research Council, and Swedish Council for Working Life and Social Research to GB. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist. * E-mail: Georgy.Bakalkin@farmbio.uu. se . These authors contributed equally to this work. ¤ Current address: Department of Pharmacy, Quaid-I-Azam University, Islamabad, Pakistan
Mechanics of Advanced Composite Structures

Piezoelectric Microbeam strain gradient theory Nonlinear geometry Primary resonance Sub/super harmonic In this research, the nonlinear dynamics of an electrostatically actuated non-uniform microbeam equipped with a damping film and a piezoelectric layer have been studied. The nonlinear behaviour of the system was modelled using the von Karman geometrical strain terms. In addition, the strain gradient theory was utilized and the Hamilton principle was applied to obtain equations of motion and boundary conditions, respectively. The obtained equations were reduced using the Galerkin method, and the reduced equations were solved with the multiple scale method. The size-dependent responses were then investigated for primary, super-harmonic, and sub-harmonic resonances. The influence of beam width, beam thickness, and distance between electrodes on the resonant frequency response was studied along with nonlinearity of the system. The results showed that the static and forced vibration behaviours of microbeams strongly depended on the size of the electrodes.