Miracle-dz/UniFAR-FTUs huggingface dataset:
Microscopy and microanalysis of complex nanosized strengthening precipitates in new generation commercial Al–Cu–Li alloys

Precipitates (ppts) in new generation aluminum–lithium alloys (AA2099 and AA2199) were characterised using scanning and transmission electron microscopy and atom probe tomography. Results obtained on the following ppts are reported: Guinier–Preston zones, T1 (Al2CuLi), β’ (Al3Zr) and δ’ (Al3Li). The focus was placed on their composition and the presence of minor elements. X‐ray energy‐dispersive spectrometry in the electron microscopes and mass spectrometry in the atom probe microscope showed that T1 ppts were enriched in zinc (Zn) and magnesium up to about 1.9 and 3.5 at. %, respectively. A concentration of 2.5 at. % Zn in the δ’ ppts was also measured. Unlike Li and copper, Zn in the T1 ppts could not be detected using electron energy‐loss spectroscopy in the transmission electron microscope because of its too low concentration and the small sizes of these ppts. Indeed, Monte Carlo simulations of EEL spectra for the Zn L2,3 edge showed that the signal‐to‐noise ratio was not high enough and that the detection limit was at least 2.5 at. %, depending on the probe current. Also, the simulation of X‐ray spectra confirmed that the detection limit was exceeded for the Zn Kα X‐ray line because the signal‐to‐noise ratio was high enough in that case, which is in agreement with our observations.
In Vitro Double Oxidation of n-Heptane with Direct Cofactor Regeneration

A novel concept for the direct oxidation of cycloalkanes to the corresponding cyclic ketones in a one-pot synthesis in water with molecular oxygen as sole oxidizing agent was reported recently. Based on this concept we have developed a new strategy for the double oxidation of n-heptane to enable a bio- catalytic resolution for the direct synthesis of heptan- A and (R)-heptanols in a one-pot reaction. The bi- catalytic cascade employs an NADH driven P450 BM3 monooxygenase variant (WT NADH , 19A12 NADH or CM1 NADH ) and an (S)-enantioselective alcohol de- hydrogenase (RE-ADH). In the initial step n-hep- tane is hydroxylated under consumption of NADH to produce (R/S)-heptanol. In the second oxidation step the (S)-heptanol enantiomers are transformed to the corresponding ketones, reducing and thereby regenerating the cofactor. Characterization of initial hydroxylation step revealed high turnover frequen- cies (TOF) of up to 600 min 1 , as well as high cou- pling efficiencies using NADH as cofactor (up to 44%). In the cascade reaction a nearly 2-fold im- proved product formation was achieved, compared to the single hydroxylation reaction. The total prod- uct concentration reached 1.1 mM, corresponding to a total turnover number (TTN) of 2500. Implementa- tion of an additional cofactor regeneration system (d-glucose/glucose dehydrogenase) enabled a further enhancement in product formation with a total prod- uct concentration of 1.8 mM and a TTN of 3500.
The Molecular Genetic Diversity of Murrah and Mehsana Buffalo Breeds through ISSR Marker

An investigation on molecular diversity of Murrah and Mehsana buffalo breeds was done to check primer discriminatory power, banding pattern of primer among fifteen accessions through ISSR. The DNA isolated from 10 ml blood by using the procedure suggested by Hoelzel (1992) who found sufficient for good quality of ISSR analysis. Out of 20 primers used only 15 produced amplicons. The total amplicons generated were 141 with 122 being polymorphic with 86.52% polymorphism. Among Primer A and Primer D could distinguish all the genotypes, the highest discriminatory index (1.0) was obtained. The Jaccard’s similarity coefficient generated on the basis of ISSR profiling showed an average similarity of 45% among all the 10 accessions. The diversity range from 23% to 77%. The SAHN clustering based on UPGMA algorithms has put genotypes in three groups, first one with 4 accessions and second one with 3 accessions and third group with 2 accessions and one accession alone. In conclusion buffalo accession harbors a good diversity. It would be valuable resource for breeding purpose.
Managing Psychosocial Issues In a Family With Diabetes

AbstractManaging diabetes in a child or teen requires constant attention and adjustment of insulin, carbohydrate intake, and activity level. Intensive diabetes management has the potential to improve diabetes outcomes; however, negotiating the many lifestyle accommodations essential to optimal diabetes control can place a significant burden on some children and families. Parenting a child with diabetes also involves a complex process of helping the child to achieve age-appropriate independence while assuring the child's safety in managing his or her diabetes. Each developmental stage brings new challenges to achieving the delicate balance between optimal diabetes control and age-appropriate independence in self-care management. Despite the laborious and intensive nature of diabetes treatment, an overarching goal of parenting a child with diabetes is to ensure that the family's quality of life is maintained and the child is able to participate in all academic and social activities that their peers enjoy. Although many families adapt and thrive, others struggle to make these adjustments. Working with families who are overwhelmed, encouraging them to identify and develop networks involving schools, extended family, community, and church groups can help them to increase available support. Helping families to access treatment when they are struggling can relieve further pain and improve management adherence and diabetes outcomes. Nurses are in a key position to evaluate the family's adaptive and coping skills and assist them to negotiate the psychosocial challenges that living with diabetes entails.
Preoperative 123 I-iomazenil SPECT imaging predicts cerebral hyperperfusion following endarterectomy for unilateral cervical internal carotid artery stenosis

Purpose: Cerebral hyperperfusion following carotid endarterectomy (CEA) occurs in patients with preoperative impairments in cerebral hemodynamics. The aim of the present study was to determine whether late images/ early images on preoperative brain 123I-iomazenil (IMZ) single-photon emission computed tomography (SPECT), which correlate with oxygen extraction fraction images on positron emission tomography, could identify patients at risk for cerebral hyperperfusion following endarterectomy for unilateral cervical internal carotid artery (ICA) stenosis. Methods: In 80 patients, preoperative brain SPECT scans were initiated immediately after (early images) and 180 min after (late images) administration of 123I-IMZ. A region of interest (ROI) was automatically placed in the middle cerebral artery territory in both the cerebral hemispheres using a three-dimensional stereotaxic ROI template. Transcranial regional cerebral oxygen saturation (rSO2) was monitored using near-infrared spectroscope throughout carotid endarterectomy, and a patient was defined as having cerebral hyperperfusion when a ratio of rSO2 at the end of the surgery to rSO2 before ICA clamping was ≥ 1.1. Results: Cerebral hyperperfusion was observed on intraoperative rSO2 monitoring in eight patients (10%). Preoperative increase in affected side-to-contralateral side asymmetry on late/ early 123I-IMZ value was the only significant independent predictor of cerebral hyperperfusion (95% confidence interval [CI], 1.606 to 8.710; P = 0.0010). The preoperative late/early 123I-IMZ asymmetry corresponded to an 88% sensitivity and 89% specificity, with 47% positiveand 98% negative-predictive values for the development of cerebral hyperperfusion. Conclusions: Preoperative late/early 123I-IMZ images can identify patients at risk for cerebral hyperperfusion following endarterectomy for unilateral cervical ICA stenosis.
Introducing Parametric Fusion PET/MRI of Primary Prostate Cancer

We assessed the performance of parametric fusion PET/MRI based on 11C-choline PET/CT and apparent diffusion coefficient (ADC) maps derived from diffusion-weighted MRI for the identification of primary prostate cancer. Methods: 11C-choline PET/CT and MRI were performed in 17 patients with untreated primary prostate cancer, followed by prostatectomy. Registration of in vivo imaging with histology was achieved using a mutual-information objective function and by performing ex vivo MRI of the prostatectomy specimen (obtained at 3 T) and whole-mount sectioning with block-face photography as intermediate steps. Data analysis included volumetrically registered whole-mount histology with Gleason scoring, 11C-choline, and ADC data (obtained at 1.5 T). Volumes of interest were defined on the basis of histologically proven tumor tissue to calculate tumor–to–benign prostate background ratios (TBRs) for 11C-choline, ADC, and a derived fusion PET/MRI parameter calculating the quotient of 11C-choline over ADC (PCHOL/ADC). Results: Fifty-one tumor nodules were identified at pathology. The TBRs for 11C-choline (P < 0.05) and PCHOL/ADC (P < 0.005) were significantly higher in prostate cancers with a Gleason score of ≥3 + 4 than with a Gleason score of ≤3 + 3 disease and controls. For Gleason ≥ 3 + 4, the ADC TBRs were significantly lower than controls and Gleason ≤ 3 + 3 disease (P < 0.05). The absolute value of TBRs obtained from Gleason ≥ 3 + 4 cancers increased from ADC to 11C-choline PET/CT and from 11C-choline PET/CT to PCHOL/ADC, with each step being statistically significant. Conclusion: Our data indicate that parametric PET/MRI using PCHOL/ADC improves lesion-to-background contrast (TBRs) of Gleason ≥ 3 + 4 disease, compared with 11C-choline PET/CT or diffusion-weighted MRI, and thus hold promise that parametric imaging performed on hybrid PET/MRI may further improve identification and localization of significant primary prostate cancer.
Using GSM signals for fingerprint-based indoor positioning system

In the paper indoor localization system based on GSM using fingerprinting framework will be described and studied. Firstly fingerprinting framework will be described. Deterministic localization algorithms based on Nearest Neighbor approach will be described in detail. Described algorithms will be implemented in the simulation model. Simulations performed in Matlab environment will be aimed to investigate performance of positioning using GSM in different scenarios. Impact of radio map density and parameters of localization algorithms will be investigated to find optimal solution.
Serotyping and antimicrobial resistance of Salmonella spp. isolated from commercial flocks of laying hens in R. Macedonia.

ABSTRACT SEROTYPING AND ANTIMICROBIAL RESISTANCE OF SALMONELLA SPP. ISOLATED FROM COMMERCIAL FLOCKSOF LAYING HENS IN R. MACEDONIA Prodanov Mirko 1 , Ratkova Marija 1 , Angelovski Ljupco 1 , Jankuloski Dean 1 , Sekulovski Pavle 1 , Mrenoshki Slavcho 2 1 Food Institute, Faculty of Veterinary Medicine, University of ss. Cyril and Methodius in Skopje 2 Veterinary Institute, Faculty of Veterinary Medicine, University of ss. Cyril and Methodius in Skopje Received 4 March 2013; Received in revised form 29 April 2013; Accepted 23 May 2013In the period from October to December 2011, 61 isolates of Salmonella were isolated from ﬂ ocks of laying hens providing eggs for human consumption. Most of the isolates belonged to the serovars Enteritidis (n=35; 57.38%), Typhimurium (n=17; 27.87%) and other (n=9; 14.75%). These isolates were tested for antimicrobial resistance to ampicillin, cefotaxime, chloramphenicol, ciproﬂ oxacin, nalidixic acid, sulfamethoxazole, tetracycline, gentamicin and streptomycin. All of the tested
Immunohistochemical Localization of Proteins in the Nervous System

The immunohistological methods described in this unit can be used to determine the precise localization of neurochemicals, receptors, and proteins throughout the nervous system. Determining the localization of a protein within defined brain nuclei and neuronal cell populations can provide important clues regarding its potential function. Immunoperoxidase reactions and light microscopy are commonly used to visualize the distribution of a single primary antibody directed to an antigen of interest. Double‐labeling immunofluorescence and confocal microscopy techniques detect the localization of one protein relative to another protein and allow analysis of colocalization at a cellular and subcellular level. The colocalization of two proteins can also be quantified, allowing analysis of the extent of overlap between two labeled markers and measurements of changes in the localization of one protein relative to another following drug treatment or in animals that have been genetically modified. The theoretical limit of resolution of confocal microscopy is 0.1 to 0.2 µm.
Single-Event Burnout Hardened Structure of Power UMOSFETs With Schottky Source

This paper investigates the single-event burnout (SEB) simulation results for both the standard and hardened structure of power U-shape gate MOSFETs (UMOSFETs). The Schottky source is proposed to reduce the work of the parasitic bipolar transistor inherent to the device. The hardened structure of power UMOSFETs with the Schottky source and N buffer layer is given, which can work normally and improve the SEB performance effectively. Both 70- and 120-V power MOSFETs are simulated and discussed in this paper. The SEB threshold voltages are increased to more than 94 percent of the breakdown voltages for both 70- and 120-V hardened structure, compared to 54 percent for standard power UMOSFETs.
Recurrent Anticipatory Self-Organized Map for Robust Time Series Prediction A Recurrent Anticipatory Self-Organized Map for Robust Time Series Prediction

In robotics applications, we often have noisy data that have temporal constraints due to the real world, such as sensory sequences generated by the motion of a robot through the environment. To recover the underlying structure of this noisy stream of data, we can do clustering with a self-organized map (SOM). We can view the SOM as a generative model, and it is seen to be doing maximum-likelihood estimation in that case. It has been shown that when the SOM is working with a temporal stream of data, it is possible to convert it to a maximum a posteriori estimator by adding lateral weights between the SOM nodes. However, this method has the drawback that it assumes that the temporal data are first order Markovian. In this paper we show how to overcome this limitation. We use a simple recurrent network (SRN) to predict the priors for the SOM. Since the SRN is capable of learning sequences in the data, this overcomes the main limitation of the previous model. We also bring out the connection between our model (the RecAntSOM) and the standard predictor-corrector framework of filtering. We do some simple robot experiments to show the usefulness of our model.
Pulsed-Field Gel Electrophoresis Profile Changes Resulting from Spontaneous Chromosomal Deletions in Enterohemorrhagic Escherichia coli O157:H7 during Passage in Cattle

ABSTRACT A total of 905 enterohemorrhagic Escherichia coli (EHEC) O157:H7 isolates that were recovered from experimentally infected cattle, in addition to the inoculated strain, were analyzed by pulsed-field gel electrophoresis (PFGE). Twelve PFGE profiles other than that of the inoculated strain were observed. We successfully identified five distinct chromosomal deletions that affected the PFGE profiles using whole-genome PCR scanning and DNA sequencing analysis. The changes in PFGE profiles of EHEC O157:H7 isolates after passage through the intestinal tract of cattle were partially generated by deletion of chromosomal regions.
How to Improve Emotional Intelligence and Social Skills among Adolescents: The Development and Test of a New Microexpressions Training

This study focused on the development of emotion recognition of adolescents through the use of a microexpression training. The results showed that the new microexpression training developed for adolescents significantly affected the adolescents’ ability to detect microexpressions, however, it did not change their overall emotional intelligence and social skills. It was also found that girls had a better ability of detecting microexpressions, before and after the training. Emotion recognition is an essential element of emotional intelligence, therefore, the present study makes an important contribution by developing, and showing effectiveness of a new microexpression training designed for adolescents.
ArduWorm: A functional malware targeting arduino devices

—The Internet of Things (IoT) is a growing market which provides several beneﬁts for industry, governments and end users. However, the increasing use of embedded and pervasive devices introduces new vulnerabilities in the network. In the last years, the number of malware and exploits targeting the IoT has grown considerably, which issues a challenge for the industry and the academy. To further motivate this challenge, in this paper we describe a malware piece targeting Arduino Yun, which is a common platform used in IoT scenarios. The malware, dubbed ArduWorm, is able to bypass all the security implemented in Arduino by exploiting a memory corruption vulnerability and hijack the device. Moreover, due to the architectural ﬂaws found in Arduino Yun, the malware is able to get the control of a Linux-based microprocessor integrated in the device with full privileges, which allows it to install a backdoor and spread as a worm through the compromised network.
Constraint on hypothetical light interacting bosons from low-energy neutron experiments.

New limits are obtained, several orders of magnitude lower than previously reported, for coupling constant versus mass for the exchange of hypothetical light bosons coupling to baryons in the range 20 MeV{gt}{ital m}{sub {ital B}c}{sup 2}{gt}20 {mu}eV (interaction range 10 fm{lt}{ital R}{sub int}{lt}1 cm). These limits are obtained from neutron-nucleus scattering below 10 keV and from neutron optics data. This closes the gap between high-energy physics and the macroscopic fifth-force experiments in the searches for new interactions. Constraints for the mass of a Higgs boson are extracted.
Phase calibration in mutual injection-pulled quadrature oscillators

An alternative approach to analysis, design and implementation of injection-locked quadrature oscillators is proposed in this paper. A novel technique is presented which allows the effects of the mismatches due to imbalances in the I/Q paths in transceivers (TRX) to be mitigated, and hence the orthogonality of the these vectors be maintained. This technique alleviates the effects of imbalances in a transceiver between I/Q paths, which would otherwise pose many threats to the performance of the system, namely image rejection ratio (IRR) degradation, gain reduction in mixers, desensitization of the RX, and ect. As a design example, a CMOS quadrature oscillator (QOSC) at the frequency of 3.5GHz has been designed and simulated using TSMC 0. 18μm technology. Monte-Carlo simulations have also been performed which indicate that the design is robust to unwanted PVT variations.
Nitrosovibrio spp., the Dominant Ammonia-Oxidizing Bacteria in Building Sandstone

In five historical buildings in the Federal Republic of Germany, ammonia-oxidizing bacteria of the genera Nitrosovibrio, Nitrosospira, and Nitrosomonas were detected in high cell numbers. In building stones, Nitrosovibrio was the most abundant ammonia-oxidizing organism. In the soil at the foot of each building, Nitrosomonas spp. were the most common ammonia oxidizers, whereas Nitrosovibrio spp. were not detected.
Mitochondrial creatine kinase activity and phosphate shuttling are acutely regulated by exercise in human skeletal muscle

• ATP transfer from mitochondria to the cytoplasm occurs mainly through phosphate transfer to creatine by mitochondrial creatine kinase (miCK) but also by transport and/or diffusion of ADP and ATP through specific mitochondrial transport protein complexes. • Determining the effect of exercise on phosphate shuttling may require contractile signals in situ and varying creatine concentrations to alter miCK activity. • Mitochondrial respiratory sensitivity to ADP was assessed in permeabilized muscle fibre bundles (PmFBs) before and after 2 h cycling exercise in human skeletal muscle. • In relaxed PmFBs, ADP sensitivity decreased post‐exercise when miCK phosphate shuttling was low (no creatine) with no change in net ADP sensitivity in the presence of creatine, whereas in contracting fibres post‐exercise ADP sensitivity was higher with creatine. • This shows miCK activity is increased post‐exercise, especially during contraction in PmFBs, and suggests exercise regulates phosphate shuttling, which would improve maintenance of energy homeostasis during contraction.
An empirical study of multilingual and low-resource spoken term detection using deep neural networks

As a further step of our previous work, this paper focuses on how to promote the multilingual spoken term detection (STD) system by the use of shared-hidden-layer multilingual DNN (SHL-MDNN). Seven languages namely Arabic, English, German, Japanese, Korean, Mandarin and Spanish are used in our experiments. Compared with our original multilingual STD system, which is based on Subspace GMMs (SGMMs), the resulting system reduces the average equal error rate (EER) on seven languages by 17.2%. Our STD system is also evaluated under low-resource conditions in this paper. We choose Mandarin and English as two target languages and simulate different degrees of available resources. The experimental results show that with the help of cross-lingual model transfer, our STD system can be elevated a lot in low-resource settings. To further improve the performance, we also attempt to use dropout strategy during the process of cross-lingual model transfer. However, no signiﬁcant improvement can be observed in our experiments. This indicates the dropout method is not so effective on cross-lingual model transfer task.