Miracle-dz/UniFAR-FTUs huggingface dataset:
Mechanisms of Acquired Resistance to Savolitinib, a Selective MET Inhibitor in MET-Amplified Gastric Cancer

PURPOSE Some gastric cancers harbor MET gene amplifications that can be targeted by selective MET inhibitors to achieve tumor responses, but resistance eventually develops. Savolitinib, a selective MET inhibitor, is beneficial for treating patients with MET-driven gastric cancer. Understanding the resistance mechanisms is important for optimizing postfailure treatment options. PATIENTS AND METHODS Here, we identified the mechanisms of acquired resistance to savolitinib in 3 patients with gastric cancer and MET-amplified tumors who showed a clinical response and then cancer progression. Longitudinal circulating tumor DNA (ctDNA) is useful for monitoring resistance during treatment and progression when rebiopsy cannot be performed. RESULTS Using a next-generation sequencing 100-gene panel, we identified the target mechanisms of resistance MET D1228V/N/H and Y1230C mutations or high copy number MET gene amplifications that emerge when resistance to savolitinib develops in patients with MET-amplified gastric cancer. CONCLUSION We demonstrated the utility of ctDNA in gastric cancer and confirmed this approach using baseline tumor tissue or rebiopsy.
Dietary Nitrate improves Cerebral Perfusion, in Young Adults during Exercise: Relationship to Cognitive Performance

Dietary nitrate increases middle cerebral artery mean velocity (MCA Vmean) during aerobic exercise but it remains unclear if this is true with the simultaneous inclusion of a cognitively demanding task. Therefore, our aim was to investigate whether nitrate supplementation would influence exercise‐induced changes in MCA Vmean, and cognitive performance.
CORRELATION OF STATIC BALANCE WITH KNEE PROPRIOCEPTION IN ELDERLY

CORRELATION OF STATIC BALANCE WITH KNEE PROPRIOCEPTION IN ELDERLY Varsha. Solanki *1, Saraswati. Iyer 2. *1 Post-graduate Research Student, P.T. School and Centre, Seth Gordhandas Sunderdas Medical College & King Edward Memorial Hospital, Parel, Mumbai, India. 2 Professor and Head of Department, P.T. School and Centre, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Parel, Mumbai, India.
Frequency-Stabilized Links for Coherent WDM Fiber Interconnects in the Datacenter

The continued growth in Hyperscale data center (HDC) deployment is expected to drive world-wide Internet traffic to an astounding 21 zettabytes by 2021. This growth will place increased demands on data center interconnects (DCIs) and drive the capacity of the underlying electronic application specific integrated circuit (ASIC) switch chips that route DCI ethernet traffic, from 12.8 Tbps per chip today to 100 Tbps and beyond in the future. This astounding growth will push the limits of today's incoherent fiber link technologies that connect switches, including power dissipation, density, and practical engineering solutions. To overcome these limits, high capacity coherent WDM, traditionally relegated to the metro and long-haul networks, will need to move into the DCI. However, migrating coherent WDM into the DCI, particularly for link distances less than 2 km, will require elimination of power consuming and costly technologies like the digital signal processor (DSP). Additionally, new photonic integration technologies will be needed to co-locate the coherent optical interfaces directly with switch ASICs to alleviate the bandwidth, power, and density limits. In this article, we introduce a new approach to DSP-free coherent WDM for the DCI called FRESCO: FREquency Stabilized Coherent Optical Links for Low Energy DCIs. FRESCO utilizes spectrally pure, ultra-stable light source technology, normally associated with high-end scientific applications like atomic clocks, to enable high capacity high-order WDM QAM with low bandwidth, low power electronics normally associated with RF links. Terabits per second FRESCO links based on shared, stabilized sources and high-density coherent WDM silicon photonic coherent transceivers that are co-located with the switch ASIC will pave the way to a DSP-free coherent WDM scalable DCI solution.
tumor suppressor gene INK4arepression complexes binding to and silencing p16 pRB family proteins are required for H3K27 trimethylation and

The mammalian pRB family proteins, pRB, p107, andp130 (also known as pocket proteins), play a key role incontrolling the G1-to-S transition of the cell cycle andmaintaining differentiated cells in a reversible quiescentor permanent senescent arrest state (Weinberg 1995; Co-brinik 2005). The pocket proteins are hypophosphory-lated in cells exiting mitosis as well as in quiescent cells,where they bind to and negatively regulate the functionof the E2F family transcription factors (Trimarchi andLees 2002). In cells entering the cell cycle, extracellularmitogens first induce the expression of D-type cyclins,which bind to and activate CDK4 and CDK6, leading tothe phosphorylation of pRB family proteins, causingfunctional inactivation by E2F dissociation, thereby pro-moting a G1-to-S transition. Inhibition of CDK4 andCDK6 by the INK4 family of CDK inhibitors (p16
Design of the Depth Controller for a Floating Ocean Seismograph

Floating ocean seismograph (FOS) is a vertical underwater vehicle used to detect ocean earthquakes by observing P waves at teleseismic distances in the oceans. With the requirements of rising to the surface and transmitting data to the satellite in real time and diving to the desired depth and recording signals, the depth control of FOS needs to be zero overshoot and accurate with fast response. So far, it remains challenging to implement such depth control due to the variation of buoyancy caused by the seawater density varying with the depth. The deeper the water is, the greater the impacts on buoyancy are. To tackle it, a fuzzy sliding mode controller considering the influence of seawater density change is proposed and simulated in MATLAB/SIMULINK based on the variable buoyancy system and state space function of FOS. Compared with proportional-integral-derivative (PID) controller, fuzzy PID controller and sliding mode controller, the simulation results indicate that the proposed controller shows its superiority regardless of the disturbing force. Its advantages include smaller steady-state error, faster response time, smaller system chatter, and well robustness. This proves that the designed fuzzy sliding mode controller is able to meet the working requirements and thus, lays a foundation for FOS application.
A Study of Temperature-Dependent Hysteresis Curves for a Magnetocaloric Composite Based on La(Fe, Mn, Si)13-H Type Alloys

In the present paper, the effect of temperature on the shape of magnetic hysteresis loops for a magnetocaloric composite core was studied. The composite core, based on La(Fe, Mn, Si)13-H, was set up using three component disks with different Curie temperatures. The magnetic properties of the components and the outcome composite core were determined using a self-developed measurement setup. For the description of hysteresis loops, the phenomenological T(x) model was used. The presented methodology might be useful for the designers of magnetic active regenerators.
Changes in gut evacuation time of larval mud crab, Scylla serrata (Crustacea: Portunidae) fed artificial plankton or live food.

To understand the feeding and digestive strategies of Scylla serrata larva and juvenile at various stages, gut evacuation time (GET) at different developmental stage were determined in the present study. GET in larval S. serrata ranged from 80 min in early zoeal stages to about 120–135 min in megalopa and crab first instar stages. GET differed significantly between stages and between diet but the interaction of stage and diet was not significant. GET for the artificial food is significantly longer than that for the live food. Movement of both the artificial (AF) and live food (LF) along the gut were traced from the hepatopancreas (HP) to the 2nd, 3rd, 4th and 5th abdominal segments (A.S.), midgut (MG), hindgut (HG), near telson and during evacuation. There were very slight differences between the movement of both food at Z1 and Z2. Starting from Z3 to Z5, LF moved faster than the AF but at the megalopa stage, both foods moved from HP to the 5th A.S. at the same time; the AF group exhibited delayed movement from MG until evacuation. At the C1 stage, both foods were only visible at the MG and their separation in time became marked i.e. the AF moving markedly slower than did the LF exhibiting GET values of 135 and 120 min, respectively. Thus, it appeared that the feeding strategy of the S. serrata larvae and juvenile modulated GET and digestive enzyme activities in response to the apparent digestibility of food presented.
A Qualitative Study on the Psychological Needs of Hospitalized Newborns’ Parents During COVID-19 Outbreak in China

Background: As the 2019 novel coronavirus disease (COVID-19) emerged in China, the parents of hospitalized neonatal patients commonly endure more psychological stress compared to the general population, which probably originated from not staying with their children, inconvenience of daily life, and financial crisis. Objectives: We investigated the psychological needs of hospitalized newborns’ parents during the COVID-19 outbreak in Chongqing, China. Methods: The phenomenological method was used to conduct this qualitative research. In-depth interviews were carried out on 14 parents of hospitalized newborns by the same interview based on a semi-structured interview outlines. The interviews were audio-taped, transcribed, and analyzed using Colaizzi’s 7-step analysis method. Results: All the subjects’ children were admitted to a neonatal ward within the first two weeks of initiating the first-level response to COVID-19 in Chongqing, China. The in-depth interviews identified five themes regarding the parents’ primary psychological needs, which included urgent demand for timely up-to-date information about the children’s condition, demand for psychological and emotional support, reducing the inconvenience caused by the epidemic outbreak, claim for protective information after discharge, demand for financial support. Conclusions: Based on the parents’ needs, the medical staff should actively communicate with the parents, effectively provide emotional and financial support, and convenience. Such support could be helpful to relieve the parents’ psychological stress.
Investigating Scrape-Off Layer transport in alternative divertor geometries on the TCV tokamak

Thermonuclear fusion is a potentially clean and limitless energy source that can substantially change the current global electricity generation mix, which is highly dependent on limited fossil fuels. This thesis contributes to the development of fusion energy with experiments on the TCV tokamak, addressing power exhaust in the divertor, which remains a major issue for a fusion tokamak reactor. A large fraction of the heating power needed to keep the plasma at the parameters required for fusion reactions, is continuously transported by the plasma across closed magnetic surfaces into a thin layer with open field lines surrounding the plasma, the Scrape-Off Layer (SOL), where it follows magnetic field lines towards the divertor targets. Unmitigated target peak heat fluxes in a fusion reactor are projected to greatly exceed available material limits. While acceptable target conditions may be possible by operating the divertor in a detached regime, a degradation of core plasma performance may ensue. A unification of a performant core and a detached divertor may be possible using alternative magnetic configurations to the standard Single-Null (SN). This thesis assesses the power exhaust properties over an unprecedented range of alternative magnetic configurations with the goals of both reducing the power exhaust challenge through divertor geometry modifications and improving the current understanding of SOL transport physics. TCV’s infrared thermography systems are extensively used to measure divertor target heat fluxes, fitted to extract the SOL heat power width λq,u and the spreading factor Su. Power sharing between divertor targets significantly varies with the plasma and/or divertor geometry, mostly interpreted as the effect of parallel electron heat conduction. The λq,u is found sensitive to properties of the plasma core, shape of the plasma and the divertor, and is consistent with empirical cross-machine scalings. The dependence on plasma current can be mostly understood with a model based on the competition between parallel and perpendicular diffusive transport. Poloidal asymmetries and field direction effects indicate that more physics is needed. The Su scales with the inverse of the target flux expansion. In the Low-Field-Side Snowflake Minus configuration, the secondary x-point enhances cross-field transport in the divertor, consistently with turbulence simulations. At the Lto H-mode transition, cross-field transport reduces in the main and divertor SOL, suggesting that the edge transport barrier propagates into the SOL. The upstream λq,u between Type-I ELMs agrees with cross-machine scaling predictions only with the toroidal magnetic field as regression parameter, revealing that this field dependence is vital. A comparison of the ELM power deposition duration
Samothraki in Transition: A Report on a Real-World Lab to Promote the Sustainability of a Greek Island

This is a case study on a small mountainous island in the Aegean Sea with the policy goal of preparing it to become member of UNESCO’s World Network of Biosphere Reserves. While the local community opted for such an identity very early on, there are a number of obstacles to be overcome. The multidisciplinary research is based upon a sociometabolic approach and focuses on two issues: The transformation of agriculture, mainly herding of sheep and goats, and the shift to tourism. The degradation of the landscape caused by extensive roaming of goats and sheep constitute one of the major sustainability challenges of the island. We analyze farmers’ opportunities and describe new initiatives to get out of this deadlock. The impacts of the transition to tourism are addressed from an infrastructural perspective: A shift from traditional stone buildings to bricks and concrete, the establishment of new roads and ports, and the challenges to water supply and wastewater removal, also with reference to the quality and amounts of wastes generated that need to be dealt with. The island has so far escaped mass tourism and attracts mainly eco-tourists who value its remoteness and wilderness. We discuss how to serve this clientele best in the future, and increase local job opportunities and income while maintaining environmental quality. Finally, we reflect upon emerging new forms of local collaboration and the impact of our research efforts on a sustainability transition that might be on its way.
Sustainable Solar Energy in Mexican Universities. Case Study: The National School of Higher Studies Juriquilla (UNAM)

Universities around the world should be at the forefront of energy-saving and efficiency processes, seeking to be at the same level or preferably higher than the rest of society, and seeking the goal of 20% renewable energy by 2020. Sustainability practices have been carried out by several universities. In Mexico, the National Autonomous University of Mexico (UNAM) is a leader in this subject; in fact, the newest National School of Higher Studies - Juriquilla (ENES-J) that belongs to UNAM, located in the city of Queretaro (Mexico), is involved in its sustainability plan, with one of its main objectives being to save electric energy. UNAM has some campuses outside of Mexico City, and one of them is the National School of Higher Studies Juriquilla (ENES-J) in the state of Queretaro, where there is the Orthotics and Prosthetics Laboratory (OPL), in which has been installed a Computer Numerical Control (CNC) machine type Haas Automation model UMC-750, which has 5-axis and is an effective means to reduce the number of setups and increase accuracy for multi-sided and complex parts. This machine will be used to design, build, and assess human prosthesis. This study aimed to contribute to sustainability policies at the ENES-J from UNAM, implementing a solar photovoltaic system (PVS) to deliver electricity to the grid and contribute to reducing the electricity load at the Orthotics and Prosthetics Laboratory (OPL), as well to propose new research lines to support the sustainability policies in universities, and also proposing a financial analysis. To achieve this, in an area of 96.7 m2, 50 solar panels type mono-Si Advance Power API-M330 with an efficiency of 17.83% and a capacity factor of 20.4% will be installed and will provide 17.25 kW of power and 345 kWh of energy. The financial analysis shows the initial costs of 46,575 USD/kW, operation and maintenance (O&M) costs (savings) of 569 USD/kW-year, a monthly electricity export rate of 0.10 USD/kWh, electricity exported to the grid of 21.5 MWh, and an electricity export revenue of 2,145 USD. To assess the environmental balance with this PVS at ENES-J, an analysis of greenhouse gases (GHG) is carried out by using the RETScreen software. In this analysis, a GHG emission factor of 0.45 tCO2/MWh was found, as well as a savings of 12,089 USD per year.
Understanding the Variability of West African Summer Monsoon Rainfall: Contrasting Tropospheric Features and Monsoon Index

West African Summer Monsoon (WASM) rainfall exhibits large variability at interannual and decadal timescales, causing droughts and floods in many years. Therefore it is important to investigate the major tropospheric features controlling the WASM rainfall and explore its potential to develop an objective monsoon index. In this study, monthly mean reanalysis data from the National Centers for Environmental Prediction/National Center for Atmospheric Research (NCEP/NCAR) and monthly rainfall data from three gridded observations during the 65-year period of 1950–2014 were employed. Dry and wet rainfall years were identified using a standardized precipitation index. In a composite analysis of wet and dry years, the dynamical features controlling the WASM exhibit an obvious contrast between these years, and a weaker (stronger) African Easterly Jet (Tropical Easterly Jet) is observed during the wet years. Also, a well-developed and deep low-level westerly flow at about 850 hPa is evident in wet years while an obvious reversal is observed in dry years. Considering this, the main regions of the two easterly jet streams and low-level westerly wind are proposed for objectively defining an effective WASM index (WASMI). The results indicate that the WASMI defined herein can reflect variations in June–September rainfall over West Africa. The index exhibits most of the variabilities observed in the rainfall series, with high (low) index values occurring in the 1950–1960s (1970–1980s), suggesting that the WASMI is skilled in capturing the respective wet and dry rainfall episodes over the region. Also, the WASMI is significantly correlated (r = 0.8) with summer monsoon rainfall, which further affirms that it can indicate not only variability but also the intensity of WASM rainfall.
Seizures and Cardiomyopathy in a Patient with Pallister-Killian Syndrome due to Hexasomy 12p Mosaicism

Pallister-Killian syndrome (PKS) is a rare disorder presenting with developmental delay, numerous dysmorphic features, and skin pigmentation anomalies. It is caused by mosaic tetrasomy of the short arm of chromosome 12. In most instances, tetrasomy is due to a supernumerary isochromosome i(12)(p10). Although mitotic instability is a generally accepted behavior for supernumerary chromosomes, hexasomy 12p due to a gain of an isochromosome 12p, has been hardly ever reported. We report a 10 year follow-up on a girl with 2 copies of isochromosome consisting of the short arm of chromosome 12, who has craniofacial features seen in PKS, such as sparse hair with an unusual pattern, sparse eyebrows, lacrimal duct stenosis, submucous cleft palate, Pallister lip (a relatively long philtrum continuing into the vermillion border of the upper lip), narrow palate, and wide alveolar ridges. She also has other abnormalities, including unilateral renal dysgenesis, rectovaginal fistula, pre-axial polydactyly of the right hand, severe global developmental delay, and hypotonia as well as some features suggestive of mosaicism such as bilateral asymmetry, patchy areas of rough skin, and retinal mottling. Initial cytogenetic studies from peripheral blood showed a normal female karyotype. Further cytogenetic studies on a skin biopsy showed mosaicism with 2 copies of the supernumerary isochromosome 12p.
Corrdrop: Correlation Based Dropout for Convolutional Neural Networks

Convolutional neural networks (CNNs) can be easily over-fitted when they are over-parametered. The popular dropout that drops feature units randomly can’t always work well for CNNs, due to the problem of under-dropping. To eliminate this problem, some structural dropout methods such as SpatialDropout, Cutout and DropBlock have been proposed. However, these methods that drop feature units in continuous regions randomly, may have the risk of over-dropping, thus leading to degradation of performance. To address these issues, we propose a novel structural dropout method, Correlation based Dropout (CorrDrop), to regularize CNNs by dropping feature units based on feature correlation, which reflects the discriminative information in feature maps. Specifically, the proposed method first obtains correlation map based on the activation in the feature maps, and then adaptively masks out those regions with small average correlation. Thus, the proposed method can regularize CNNs well by discarding part of contextual regions. Extensive experiments on image classification demonstrate the superiority of our method compared with other counterparts.
Pain inhibition is not affected by exercise-induced pain

Abstract Introduction: Offset analgesia (OA) and conditioned pain modulation (CPM) are frequently used paradigms to assess the descending pain modulation system. Recently, it was shown that both paradigms are reduced in chronic pain, but the influence of acute pain has not yet been adequately examined. Objectives: The aim of this study is to investigate OA and CPM after exercise-induced pain to evaluate whether these tests can be influenced by delayed-onset muscle soreness (DOMS) at a local or remote body site. Methods: Forty-two healthy adults were invited to 3 separate examination days: a baseline appointment, the consecutive day, and 7 days later. Participants were randomly divided into a rest (n = 21) and an exercise group (n = 21). The latter performed a single intensive exercise for the lower back. Before, immediately after, and on the following examination days, OA and CPM were measured at the forearm and the lower back by blinded assessor. Results: The exercise provoked a moderate pain perception and a mild delayed-onset muscle soreness on the following day. Repeated-measurements analysis of variance showed no statistically significant main effect for either OA or CPM at the forearm or lower back (P > 0.05). Conclusion: Delayed-onset muscle soreness was shown to have no effect on the inhibitory pain modulation system neither locally (at the painful body part), nor remotely. Thus, OA and CPM are robust test paradigms that probably require more intense, different, or prolonged pain to be modulated.