Miracle-dz/UniFAR-FTUs huggingface dataset:
The Association Between COVID-19 Information Sources and Stigma Against Health Care Workers Among College Students: Cross-sectional, Observational Study

Background The COVID-19 pandemic has triggered stigmatic attitudes against health care workers. Some forms of social media may play a role in disseminating stigmatizing messages. Objective We aimed to investigate the association between COVID-19 information sources and stigma against health care workers among college students during the pandemic. Methods A cross-sectional, observational study was conducted using a web-based platform in the Tohoku region of Japan. College students aged ≥20 years were asked to complete the questionnaire between August 18 and October 31, 2020. Stigma against health care workers was evaluated using a modified Japanese version of the Social Distance Scale. Participants were also asked to rate their perceived vulnerability to infection using the Japanese version of the Perceived Vulnerability to Disease scale. Results A total of 281 students from 8 colleges completed the web-based survey. There were 139 (49.5%) participants who used Twitter, 187 (66.5%) who used news websites, and 46 (16.4%) who used the websites of public health agencies as COVID-19 information sources. After adjusting for age, sex, department, and Perceived Vulnerability to Disease scores, the level of stigma did not differ between students who used Twitter and those who did not. Students who used the websites of public health agencies showed a significantly less stigmatic attitude than those who did not. Conclusions Fact-checking and directing visitors to credible information sources from public health agencies may have prevented the formation of stigmatic attitudes toward health care workers. An effective strategy to enable easy access to information provided by public agencies should be integrated into widespread web-based platforms.
The Need for Sexual Wholeness: Linking Self-Determination Theory to the Physical, Emotional, and Meaning Aspects of Sex

Abstract Sexuality is a highly complex aspect of a human’s existence with several elements contributing to a quality sexual relationship. This study examined a broad scope of sexuality encompassing physical, emotional, and meaning aspects of sex, or sexual wholeness. Sexual wholeness is grounded in the idea that a self-determined sexual relationship in which three innate human needs (autonomy, competence, and relatedness) are met is more likely to promote sexual well-being. Using a sample of 884 adults in long-term relationships, we used structural equation modeling to estimate the association between each of the three self-determination theory (SDT) needs and the physical, emotional, and meaning aspects of sex. We found that overall, greater SDT needs satisfaction predicted sexual wholeness, though some needs held more bearing than others and the associations with components of sexual wholeness varied. For women, the physical aspect of sex was predicted by autonomy (predicted comfort) and competence (predicted sexual knowledge) but for the physical aspects of sex for men, no significant associations were found. The emotional aspect of sex was associated with all three SDT needs for both men and women and sexual meaning was associated with competence and relatedness for both men and women.
Global Association of COVID-19 Pandemic Measures With Cancer Screening: A Systematic Review and Meta-analysis.

Importance Public health services, including cancer screening tests, have been affected by the onset of the COVID-19 epidemic. Objective To investigate the pandemic's association with cancer screening worldwide. Data Sources In this systematic review and meta-analysis, databases such as PubMed, ProQuest, and Scopus were searched comprehensively for articles published between January 1, 2020, and December 12, 2021. Study Selection Observational studies and articles that reported data from cancer registries that compared the number of screening tests performed before and during the pandemic for breast, cervical, and colorectal cancer were included. Data Extraction and Synthesis Two pairs of independent reviewers extracted data from the selected studies. The weighted average of the percentage variation was calculated between the 2 periods to assess the change in the number of cancer screening tests performed during the pandemic. Stratified analysis was performed by geographic area, period, and type of setting. The systematic review and meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline. Main Outcomes and Measures The main outcome was the weighted average percentage variation in the number of screening tests performed between January and October 2020 compared with the previous period. Results The review comprised 39 publications. There was an overall decrease of -46.7% (95% CI, -55.5% to -37.8%) for breast cancer screening, -44.9% (95% CI, -53.8% to -36.1%) for colorectal cancer screening, and -51.8% (95% CI, -64.7% to -38.9%) for cervical cancer screening during the pandemic. For all 3 cancers, a U-shaped temporal trend was identified; for colorectal cancer, a significant decrease was still apparent after May 2020 (in June to October, the decrease was -23.4% [95% CI, -44.4% to -2.4%]). Differences by geographic area and screening setting were also identified. Conclusions and Relevance A summary estimate of the downscaling of cancer screening tests since the onset of the COVID-19 pandemic is provided in this systematic review and meta-analysis. This could be associated with an increase in the number of avoidable cancer deaths. Effective interventions are required to restore the capacity of screening services to the prepandemic level.
Racialized Perceptions of Vegetarianism: Stereotypical Associations That Undermine Inclusion in Eating Behaviors

Shifting societal eating patterns toward a vegetarian diet offers promise for improving public health and environmental sustainability. Yet concerns exist about racial disparities in inclusion, as some sentiments suggest that vegetarianism is stereotypically associated with Whiteness. Through four studies (total N = 3,234), we investigated associations U.S. adults hold between race and vegetarianism, along with implications for behavior change and belongingness among Black individuals. Participants, across racial backgrounds, strongly associated vegetarianism with Whiteness, both explicitly and implicitly. A race prime led Black participants to report lower interest in becoming a vegetarian, whereas a prime of race-vegetarianism associations decreased Black participants’ feelings of belongingness in the vegetarian community. Exposure to racially inclusive messaging about vegetarianism, meanwhile, increased belongingness among Black participants. These findings provide the first quantitative insights into racial stereotypes about vegetarianism and pose future directions for theory, research, and practice at the intersections of race and eating behavior.
Delivery, structure, and function of bacterial genotoxins

ABSTRACT Bacterial genotoxins are peptide or protein virulence factors produced by several pathogens, which make single-strand breaks (SSBs) and/or double-strand DNA breaks (DSBs) in the target host cells. If host DNA inflictions are not resolved on time, host cell apoptosis, cell senescence, and/or even bacterial pathogen-related cancer may occur. Two multi-protein AB toxins, cytolethal distending toxin (CDT) produced by over 30 bacterial pathogens and typhoid toxin from Salmonella Typhi, as well as small polyketide-peptides named colibactin that causes the DNA interstrand cross-linking and subsequent DSBs is the most well-characterized bacterial genotoxins. Using these three examples, this review discusses the mechanisms by which these toxins deliver themselves into the nucleus of the target host cells and exert their genotoxic functions at the structural and functional levels.
Distinct activities of Vδ1+ T‐cells upon different cytomegalovirus reactivation status after haematopoietic transplantation

Cytomegalovirus (CMV) reactivation is the most frequent viral infectious complication correlating to non‐relapse mortality after allogeneic haematopoietic cell transplantation (alloHCT). The intrinsic anti‐CMV immunity has not been completely elucidated. γδ T‐cells have drawn increasing attentions due to their distinct biological features and potential ability against viral infections. Previous studies reported a general association of γδ T‐cells or Vδ2‐negative γδ T‐cells with CMV reactivation. Whereas researches for the direct responses and specific functions of γδ T subsets remain limited, especially in the scenario of alloHCT. Herein, we initially demonstrated that Vδ1+ T‐cells directly and independently recognized cell‐free CMV and CMV‐infected target cells, and inhibited CMV replication in vitro. The anti‐CMV effect of Vδ1+ T‐cells was partially through TCRγδ, TLR2 and NKG2D receptor pathways. Further investigation about the anti‐CMV characteristics of Vδ1+ T‐cells was performed in a clinical cohort with different CMV reactivation status after alloHCT. We found that occasional CMV reactivation remarkably increased the recovery levels and stimulated the functional activity of Vδ1+ T‐cells. Whereas disability of Vδ1+ T‐cells was observed upon refractory CMV reactivation indicating the differential responses of Vδ1+ T‐cells under different CMV reactivation status. CXCL10 and IFN‐β that were dramatically induced by occasional CMV reactivation could re‐activate the deficient Vδ1+ T‐cells from recipients with refractory CMV reactivation. These findings unveiled the distinct activities of Vδ1+ T‐cells in anti‐CMV immunity after alloHCT and may help develop novel strategies for the treatment of CMV infectious diseases.
The diagnostic and prognostic values of circulating miRNA-1246 in multiple myeloma

ABSTRACT Background/objective Bone marrow biopsy, the gold standard for the diagnosis of multiple myeloma (MM), has main limitation of the invasiveness. Here, we explored the diagnostic and prognostic values of circulating miR-1246 in patients with MM. Material and methods Ninety MM patients and 30 healthy donors (control group) were recruited in this study. The expression of miR-1246 in the peripheral blood samples was detected using qPCR. The receiver operating characteristic (ROC) curve was used to assess the diagnostic value of miR-1246 in MM. The Kaplan–Meier survival analyze was performed to evaluate the prognostic value of miR-1246. Results The expression level of serum miR-1246 from newly diagnosed MM patients was significantly higher than that of the control group. Circulating miR-1246 level was decreased after treatment in remission patients, but remained high levels in relapsed patients (P < 0.05). ROC analysis demonstrated that miR-1246 showed a high diagnostic value in MM with an area under the curve (AUC) of 0.952, the sensitivity of 87%, and the specificity of 95% [95% confidence interval (CI) 0.902-1.007; P < 0.001]. Kaplan–Meier analysis showed that the progression-free survival (PFS) (14.0 months vs. 26.5 months, P = 0.045) and overall survival (OS) (20.5 months vs. 55.5 months, P = 0.014) were significantly shorter in patients with high miR-1246 expression as compared with those in patients with miR-1246 low expression. Multiple Cox regression model analysis showed that circulating miR-1246 was an independent prognostic factor for PFS (HR 2.786, 95% CI: 1.420–5.467, P = 0.003) and OS (HR 2.995, 95% CI: 1.166–7.689, P = 0.023) in MM patients. Conclusion This study demonstrates that circulating miR-1246 level is elevated in MM patients, which shows high values in the diagnosis and prognosis prediction in patients with MM.
Direction of attentional focus in prosthetic training: Current practice and potential for improving motor learning in individuals with lower limb loss

Objective Adopting an external focus of attention has been shown to benefit motor performance and learning. However, the potential of optimizing attentional focus for improving prosthetic motor skills in lower limb prosthesis (LLP) users has not been examined. In this study, we investigated the frequency and direction of attentional focus embedded in the verbal instructions in a clinical prosthetic training setting. Methods Twenty-one adult LLP users (8 female, 13 male; 85% at K3 level; mean age = 50.5) were recruited from prosthetic clinics in the Southern Nevada region. Verbal interactions between LLP users and their prosthetists (mean experience = 10 years, range = 4–21 years) during prosthetic training were recorded. Recordings were analyzed to categorize the direction of attentional focus embedded in the instructional and feedback statements as internal, external, mixed, or unfocused. We also explored whether LLP users’ age, time since amputation, and perceived mobility were associated with the proportion of attentional focus statements they received. Results We recorded a total of 20 training sessions, yielding 904 statements of instruction from 338 minutes of training. Overall, one verbal interaction occurred every 22.1 seconds. Among the statements, 64% were internal, 9% external, 3% mixed, and 25% unfocused. Regression analysis revealed that female, older, and higher functioning LLP users were significantly more likely to receive internally-focused instructions (p = 0.006, 0.035, and 0.024, respectively). Conclusions Our results demonstrated that verbal instructions and feedback are frequently provided to LLP users during prosthetic training. Most verbal interactions are focused internally on the LLP users’ body movements and not externally on the movement effects. Impact statement While more research is needed to explore how motor learning principles may be applied to improve LLP user outcomes, clinicians should consider adopting the best available scientific evidence during treatment. Overreliance on internally-focused instructions as observed in the current study may hinder prosthetic skill learning.
Health, care or shelter? An exploratory analysis of the factors affecting overall satisfaction with services of residents’ relatives in nursing homes

Residents’ relatives are regularly solicited to evaluate the hotel, social- and health-care services that nursing homes provide to the aged in order to preserve their residual cognitive, physical, and social capabilities. In this study we argue that, due to the services’ different technical and functional elements, residents’ relatives find it easier to assess the quality of the hotel services instead of the other types of services. Based on 2012 responses from residents’ relatives in 38 nursing homes in the Northern part of Italy, our results show that satisfaction with hotel services partially mediates the impact of satisfaction with social- and health-care services, above and beyond their direct effect on the overall satisfaction with all services. We conclude by discussing theoretical contributions and managerial implications.
Nuclear Factor-κB Regulates β-Cell Death

Apoptotic β-cell death is central to the pathogenesis of type 1 diabetes and may be important in islet graft rejection. Despite this, genetic control of β-cell apoptosis is only poorly understood. We report that inhibition of gene transcription sensitized β-cells to tumor necrosis factor (TNF)-α–induced apoptosis, indicating the presence of a regulated antiapoptotic response. Using oligonucleotide microarrays and real-time PCR, we identified TNFAIP3/A20 as the most highly regulated antiapoptotic gene expressed in cytokine-stimulated human and mouse islets. Cytokine induction of A20 mRNA in primary islets and insulinoma cells was rapid and observed within 1 h, consistent with A20 being an immediate early response gene in β-cells. Regulation of A20 was nuclear factor-κB (NF-κB)–dependent, two NF-κB sites within the A20 promoter were found to be necessary and sufficient for A20 expression in β-cells. Activation of NF-κB by TNF receptor–associated factor (TRAF) 2, TRAF6, NF-κB–inducing kinase, or protein kinase D, which transduce signals downstream of Toll-like receptors, TNF receptors, and free radicals, respectively, were all potent activators of the A20 promoter. Moreover, A20 expression was induced in transplanted islets in vivo. Finally, A20 expression was sufficient to protect β-cells from TNF-induced apoptosis. These data demonstrate that A20 is the cardinal antiapoptotic gene in β-cells. Further, A20 expression is NF-κB dependent, thus linking islet proinflammatory gene responses with protection from apoptosis.
Faster ocean warming threatens richest areas of marine biodiversity

The vulnerability of marine biodiversity to accelerated rates of climatic change is poorly understood. By developing a new method for identifying extreme oceanic warming events during Earth's most recent deglaciation, and comparing these to 21st century projections, we show that future rates of ocean warming will disproportionately affect the most speciose marine communities, potentially threatening biodiversity in more than 70% of current‐day global hotspots of marine species richness. The persistence of these richest areas of marine biodiversity will require many species to move well beyond the biogeographic realm where they are endemic, at rates of redistribution not previously seen. Our approach for quantifying exposure of biodiversity to past and future rates of oceanic warming provides new context and scalable information for deriving and strengthening conservation actions to safeguard marine biodiversity under climate change.
Mathematical modeling of the impact of Omicron variant on the COVID-19 situation in South Korea

The rise of newer coronavirus disease 2019 (COVID-19) variants has brought a challenge to ending the spread of COVID-19. The variants have a different fatality, morbidity, and transmission rates and affect vaccine efficacy differently. Therefore, the impact of each new variant on the spread of COVID-19 is of interest to governments and scientists. Here, we proposed mathematical SEIQRDVP and SEIQRDV3P models to predict the impact of the Omicron variant on the spread of the COVID-19 situation in South Korea. SEIQEDVP considers one vaccine level at a time while SEIQRDV3P considers three vaccination levels (only one dose received, full doses received, and full doses + booster shots received) simultaneously. The Omicron variant’s effect was contemplated as a weighted sum of the delta and Omicron variants’ transmission rate and tuned using a hyperparameter k. Our models’ performances were compared with common models like SEIR, SEIQR, and SEIQRDVUP using the root mean square error (RMSE). SEIQRDV3P performed better than the SEIQRDVP model. Without consideration of the variant effect, we don’t see a rapid rise in COVID-19 cases and high RMSE values. But, with consideration of the Omicron variant, we predicted a continuous rapid rise in COVID-19 cases until maybe herd immunity is developed in the population. Also, the RMSE value for the SEIQRDV3P model decreased by 27.4%. Therefore, modeling the impact of any new risen variant is crucial in determining the trajectory of the spread of COVID-19 and determining policies to be implemented.
Reversibility of acute‐on‐chronic liver failure syndrome in hepatitis B virus‐infected patients with and without prior decompensation

Acute‐on‐chronic liver failure (ACLF) is a severe clinical syndrome associated with high short‐term mortality and reversibility. This study aimed to compare the characteristics of survival and reversibility in hepatitis B virus (HBV)‐related ACLF (HBV‐ACLF) patients with and without previous decompensation. Overall, 1044 patients who fulfilled the acute hepatic insult criteria of the APASL‐ACLF Research Consortium (AARC) definition were enrolled from a prospectively established cohort of HBV‐related liver failure patients. These patients were divided into the AARC ACLF group and the non‐AARC ACLF group according to prior decompensation. Mortality, reversibility of ACLF syndrome, and predicted factors associated with reversibility were evaluated. Liver transplantation‐free mortality of the AARC ACLF group was significantly lower than that of the non‐AARC ACLF group (28 days: 28.2% vs. 40.3%, p = .012; 90 days: 41.7% vs. 65.4%, p < .001). The 5‐year cumulative reversal rates of ACLF syndrome were 88.0% (374/425) and 66.0% (31/47) in the AARC and non‐AARC ACLF groups, respectively, (p = .039). Following reversibility of ACLF syndrome, 340/374 (90.9%) and 21/31 (67.7%) patients in the AARC and non‐AARC ACLF groups, respectively, maintained a stable status within 5 years. Although prior decompensation indicated poor reversibility of ACLF syndrome, HBV‐infected patients with prior decompensation who fulfilled the acute hepatic insult criteria of the AARC definition showed favourable reversibility and maintained a stable status after receiving nucleoside analogues. The AARC ACLF definition identified HBV‐ACLF as a distinct syndrome with good reversibility. HBV‐infected patients with prior decompensation could be included in the AARC ACLF management.
Clindamycin but not Intravenous Immunoglobulins reduces mortality in a retrospective cohort of critically ill patients with bacteremic Group A Streptococcal infections

Objectives Mortality of patients requiring Intensive Care Unit (ICU) admission for an invasive group A streptococcal (GAS) infection continues being high. In critically ill patients with bacteremic GAS infection we aimed at determining risk factors for mortality. Patients and methods Retrospective multicentre study carried out in nine ICU in Southern Spain. All adult patients admitted to the participant ICUs from January 2014 to June 2019 with one positive blood culture for S. pyogenes were included in this study. Patient characteristics, infection-related variables, therapeutic interventions, failure of organs, and outcomes were registered. Risk factors independently associated with ICU and in-hospital mortalities were determined by multivariate regression analyses. Results Fifty-seven patients were included: median age was 63 (45-73) years, median SOFA score at admission was 11 (7-13). The most frequent source was skin and soft tissue infection (n=32) followed by unknown origin of bacteremia (n=12). In the multivariate analysis, age (OR 1.079; 95% CI 1.016-1.145), SOFA score (OR 2.129; 95% CI 1.339-3.383) were the risk factors for ICU mortality and the use of clindamycin was identified as a protective factor (OR 0.049; 95% CI 0.003-0.737). Age and SOFA were the independent factors associated with hospital mortality however the use of clindamycin showed a strong trend but without reaching statistical significance (OR 0.085; 95% CI 0.007-1.095). Conclusion In this cohort of critically ill patients the use of intravenous immunoglobulin was not identified as a protective factor for ICU or hospital mortality treatment with clindamycin significantly reduced mortality after controlling for confounders.
Exploiting Spatio-Temporal Correlation for ReliableInformation Transport in WSNs

Delivering reliable services in service oriented architectures entails the underlying basis of having communication network models and well structured systems. With the rapid proliferation of ad-hoc mode of communication the reliable delivery of services increasingly encounter new communication and network perturbations. Empirically the core of service delivery in WSNs (Wireless Sensor Networks) is information transport from the sensor nodes to the sink node where the service resides. In this work we provide a reliable information transport for enhanced service delivery by using spatio-temporal correlation in WSN. The classification for different types of information required by the services is also presented. To overcome dynamic network conditions and evolving service requirements an adaptive retransmission mechanism based on spatial correlation is utilized. Simulation results show that the proposed solutions provide service specific reliability and save expensive retransmissions and thus provide energy efficient solution.