Miracle-dz/UniFAR-FTUs huggingface dataset:
DEVELOPMENT AND CHARACTERIZATION OF MUCOADHESIVE-THERMOSENSITIVE BUCCAL GEL CONTAINING METRONIDAZOLE FOR THE TREATMENT OF ORAL MUCOSITIS

Amac: Bu calismada oral mukozit tedavisi icin bukkal mukoza sicakliginda hizla jellesebilen, metronidazol iceren mukoadhesif-termosensitif jel formulasyonu hazirlanmasi ve karakterize edilmesi amaclanmistir. Gerec ve Yontem: Bu calismada, belirli konsantrasyonlarda poloksamer 407 (P407), poloksamer 188 (P188) ve hidroksipropil metilseluloz (HPMC) kombinasyonlari, bukkal mukozada jel olusturmak icin kullanilmistir. Optimum formulasyonlar hazirlanan formulasyonlarin jellesme suresi ve jellesme sicakligi olculerek secilmistir. Secilen formulasyonlarin sertlik, adhezif, kohezif, esneklik, puskurtulebilirlik, mukoadhezif ve salim ozellikleri degerlendirilmistir. Sonuc ve Tartisma: Sonuclar, 33 °C'de hizla jel formuna donusen F1 ve F3 formulasyonunun optimum formulasyonlar olabilecegini gostermistir. Bu iki formulasyon 8 saat boyunca kontrollu salim gostermistir. Doku profili analizi (TPA), mukoadhezyon ve puskurtulebilirlik calismalari, F1 formulasyonun, P407 (% 15), P188 (% 20) ve HPMC (% 5) kombinasyonu, bukkal mukoza icin optimum formulasyon oldugunu gostermistir. Sonuc olarak, metronidazole iceren mukoadhezif-isiya duyarli jeller oral mukozit tedavisinde iyi bir alternatif olabilir.
Computational Modeling of Cell Growth Heterogeneity in a Perfused 3D Scaffold

Our goal was to develop a computational model describing the spatiotemporal evolution of cell heterogeneity within a three-dimensional porous scaffold during cell growth in a perfusion bioreactor. The scaffold was assumed formed by an ensemble of independent parallel cylindrical channels with a defined diameter distribution. The total flow rate partitioning in each channel depends on the effective diameter, which is reduced by the cell growth on the channel wall. The mass balance for one metabolite and the cell volume balance were solved. For each channel diameter, the model simulation provide the spatiotemporal evolution of velocity, shear stress, metabolite concentration, and cell volume growth. In particular, all of these outcomes can be analyzed as a function of channel diameter providing an evaluation of cell property heterogeneity. The model describes that the cell growth can be substantially different in each channel diameter. For instance, in the small diameter channel, cell growth is limited by m.
Efficacy of the XEN-Implant in Glaucoma and a Meta-Analysis of the Literature

Background: To assess the efficacy of XEN-implant surgery in patients with glaucoma, and to perform a meta-analysis of previously published results and compare these to our data. Methods: Prospective case-control study, in which all eyes that underwent XEN-implant surgery were included from 2015 onwards. Sub-analyses were performed for eyes that underwent XEN-implant as standalone procedure and as cataract-combined procedure. To compare our results, a systematic review was performed using the Embase, PubMed, Web of Science, and Cochrane database. Meta-analyses were performed by combining data (intraocular pressure (IOP), IOP-lowering medication, and complications) from the retrieved studies. Results: A total of 221 eyes underwent XEN-implant surgery (124 standalone and 97 cataract-combined). The mean ± standard deviation IOP declined from 18.8 ± 6.5 to 13.5 ± 4.3 mmHg at the last follow-up (p < 0.001; 28.9%). Postoperative, no significant differences in IOP or IOP-lowering medication were found between patients with and without combined procedure. Secondary surgeries were performed in 20.8% of eyes, most of them (63.0%) within six months. A meta-analysis of 19 studies retrieved from the systematic review showed a two-years postoperative pooled mean (weighted mean difference) of 14.5 (7.3) mmHg and 1.0 (1.6) for IOP and IOP-lowering medications, respectively (compared to 13.5 (5.3) mmHg and 3.2 (2.4) in the current study). Conclusion: XEN-implant surgery was effective and safe in lowering IOP and the number of IOP-lowering medications. There were no differences between standalone and combined procedures.
A trinuclear silver(I) functionalized n-heterocyclic carbene complex and its use in transmetalation : Structure and catalytic activity for olefin polymerization

Deprotonation of an imidazolium salt with silver oxide forms the silver carbene complex {[Ag(C∧N)2]3I}I2 (2; C∧N = 3-methyl-1-picolylimidazolin-2-ylidene). The Ag−carbene complex undergoes a facile reaction with Pd(PhCN)2Cl2 to yield the carbene complex Pd(C∧N)Cl2 (3). Complexes 2 and 3 have been characterized by IR, 1H and 13C NMR spectra, and elemental analyses. The molecular structures of complexes 2 and 3 have been confirmed by X-ray single-crystal analyses. Complex 2 shows moderate catalytic activities of up to 105 g of PE (mol of Ag)-1 h-1 for ethylene polymerization, and complex 3 shows very high catalytic activities of up to 108 g of PNB (mol of Pd)-1 h-1 for the addition polymerization of norbornene in the presence of methylaluminoxane (MAO) as cocatalyst.
Medical Potential Of A Locally Sourced Lipids Mixture On Confirmed Corona Virus Infected Patients And Those At Risk of Infection, Attending National Hospital Abuja, Nigeria.-An Evidence Based Approach

Original Research Article Forty volunteers (comprising of four families whose members were both amalgamation of nuclear and extended) and eight COVID 19 disease confirmed positive cases unisex attending National Hospital Abuja either as in /out patients randomly participated in this pilot study; The sole objective was to determine the effectiveness of Joseleen herbal lipids mixture as both therapeutic and prophylactic agent against COVID 19 disease. We initially proposed Joseleen Herbal Mixture as a prophylactic agent for COVID19 disease, following its high potential of protecting individuals against Coronavirus infection, as evidenced from haemagglutination inhibition assay 16,17 carried out using influenza virus, a closely related virus with 80% sequence homology. Randomized assay conducted on those infected with COVID 19 disease revealed its high therapeutic potential, after administering informed consent questionnaires to volunteers. Four indicators were used to critically appraise the herbal lipids mixture. These were, Percentage overall rating of the herbal lipids Mixture by volunteers; Their prophylactic experience with the herbal mixture after staying with COVID 19 patients for a period between 20 – 60 days; Curative experience of the volunteers who were infected initially with corona virus; Side effect experience of these same group of volunteers. The outcomes showed, percentage ratings of 83.1%, 94.43%, 100% and 17% respectively. ANOVA statistic technique revealed significantly different high percentage ratings among the first three indicators (P ≤ 0.05). However, the side effect percentage rating was significantly lower than the other three indicators (P≤ 0.05). Thus, Joseleen herbal mixture is both effectively therapeutic and prophylactic against COVID 19 pandemic disease. The case fatality rate was zero % with respect to this research, using Joseleen herbal lipids mixture as COVID 19 remedy.
Hepatocellular Carcinoma: A Review

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. Chronic liver disease due to viral hepatitis, alcohol, non-alcoholic fatty liver disease, etc are risk factors for HCC development. Triphasic contrast-enhanced computed tomography (CECT) and magnetic resonance imaging (MRI) abdomen are modalities for HCC diagnosis best for lesions >2 cm size. For lesions <2 cm size, liquid biopsy with the determination of cell-free DNA in the blood is a newly emerging technique for diagnosis as well as for the planning of molecular targeted therapy. With the new concept of “Treatment stage migration”, the updated Barcelona clinic liver cancer (BCLC) algorithm for HCC management allows the best treatment modality for an individual patient. In addition to definitive therapy of resection and liver transplantation, palliative therapies like ablation, transarterial embolization, and others can be used. Among molecular targeted therapies for advanced BCLC stage C HCC, lenvatinib as first line, regorafenib and cabozantinib as second line therapy have been approved recently. The checkpoint inhibitors (CPIs), nivolumab and pembrolizumab, have revolutionized oncology practice in other solid organ cancers and have shown promising results in HCC management.
Quantum Statistical Mechanical Theory of the Rate of Exchange Chemical Reactions in the Gas Phase

A theory of the reaction rate of simple exchange reactions in the gas phase is developed on the basis of the quantum‐statistical mechanical theory of linear irreversible processes due to Kubo et al. A formal expression for the rate coefficient is found near the equilibrium point. A number of relations are derived concerning the scattering amplitudes for the collisions involved in the above reactions. By making use of these relations, the rate constant is expressed in terms of the reaction cross sections in a way which coincides with that known from a more intuitive collisional approach. Since no ad hoc assumptions are made, the present theory can be said to provide a statistical mechanical foundation for the collision theory in the particular case discussed.
Experimental analysis of repairing H14 die steel surface by laser cladding

The damage of die metal parts is one of the key problems that affect its normal use. Laser cladding technology can solve this problem quickly and effectively. In this paper, the tungsten alloy powder was cladding on the metal surface by laser cladding, and the surface repair and strengthening technology were carried out. The influence of laser scanning speed on the microstructure of cladding layer metal was studied. The experimental results show that the metal parts with surface damage are repaired by laser cladding technology, and the cermet protective layer without pores and cracks is obtained. The hardness value of laser cladding layer is greatly improved than that of base material, which lays a good foundation for improving material performance.
Effect of Organic and Inorganic Fertilization on Growth and Yield of French Bean (Phaseolus vulgaris L.) in Fiji

Background: French bean is used both as dry seeds or as green pod vegetable and it is in increasing demand throughout Fiji. Limited agronomical information is available for its cultivation which is one of the barriers in increasing its production in country. This research aimed to study the influence of organic and inorganic fertilizers on growth and yield of (Phaseolus vulgaris L.) in Fiji. Methods: This research was conducted during April to September 2018 in a Randomized Block Design with three replications and seven treatments of organic and inorganic fertilizers. Observations on growth parameters and yield attributes were recorded and analyzed using analysis of variance technique. Result: Organic and inorganic fertilizers combinations significantly increase the growth and green pod yield of French bean. The applications of nutrient in combination of organic and inorganic fertilizers were found more effective than inorganic fertilizers or organic manure alone for growth and yield of French bean. The combination of 100% NPK (200 kg ha-1) along with Poultry manure @ 5 t ha-1 was found most effective for enhancing growth and yield. It was recorded that on the basis of yield and growth performance treatment 100% NPK along with PM @ 5 t ha-1 was superior.
Verification of Full-Scale Ozone Contactor Inactivation Performance Using Biodosimetry

A biodosimetric technique was used to verify the concentration-contact time (CT) values [ CT10 , CT integrated disinfection design framework (CT-IDDF), CT segregated flow analysis (CT-SFA)] of the ozone contactors of the DesBaillets water treatment plant (Montreal), using indigenous aerobic spore formers (ASFs) as indicators of disinfection efficiency. ASF measurement in ozonated water was performed using a large water sample concentration method. Four assays, completed over a 6-week period, involved the implementation of biodosimetric calibration curves using an ozone pilot apparatus and followed by full-scale verifications. ASF inactivation kinetics were well described by a simple Chick–Watson model. The most accurate data also indicated that the CT10 underestimates the effective CT (by 1.2–1.9-fold), whereas the CT-IDDF and CT-SFA overestimate it (by 1.0–1.7-fold and 0.9–1.5-fold, respectively). Underestimation from CT10 was more pronounced with increased ozone dose while overestimation from CT-IDDF an.
Calculation and Optimization of Propulsion Force of a Real-Scale REBCO Magnet for EDS Train

Electrodynamic suspension (EDS) train has the unique advantages of excellent levitation and guidance stabilities, large levitation gap, and so on. All of these merits make it a promising candidate for the future ultra-high-speed transportations, in which the high-temperature superconducting (HTS) linearly synchronous driving motor (LSM) plays an important role because of the decrease of energy consumption of HTS magnet. This paper, which serves as a fundamental study on the HTS synchronous driving system of EDS train, is aimed to calculate the propulsion force of LSM and optimize the propulsion fluctuation. First, in order to define the operating current of LSM, the critical current of a real-scale REBCO coil was numerically estimated using the so-called T-A model. Second, based on the Neumann formula and virtual displacement method, an analytic model to estimate the propulsion force of LSM was established and verified by comparing results with a finite-element method (FEM) numerical model. Finally, by resorting to the validated analytic model, the geometric parameters of propulsion coil were optimized, and then using the optimal parameters, the maximum electromagnetic forces of LSM under different operating conditions of EDS train were calculated. It was found that the linearly driving system inherently keeps robust driving stability to the lateral and normal displacements.
Climate transition risk in New Zealand equities

ABSTRACT We examine climate transition risk in New Zealand (NZ) equities given that NZ’s greenhouse gas (GHG) emissions are dominated by agricultural emissions and that carbon pricing has been in place since 2008. We find disclosure has grown rapidly from 2010 and that disclosure is driven by, inter alia, size and sector membership (Energy, Manufacturing and Primary Industries). However, by 2018, only around half of NZX50 companies regularly disclose emissions, though this should increase steadily as NZ will adopt mandatory disclosures from 2023 onwards on a ‘report or explain basis’. In terms of ‘hypothetical carbon liabilities’, Genesis Energy and Air New Zealand are most exposed for Scope 1 and 2 emissions, but when upstream scope 3 GHG emissions are added, Fonterra (multinational dairy firm) is most at-risk. An asset pricing analysis shows that only volatility and extreme price movements in carbon price returns are priced. Overall, the results suggest that despite there being material climate transition risks for NZX50 equities, limited disclosure and low carbon prices mean that these risks are not likely to be fully priced in stock values.
A Sampling and Analytical Method for Ethylene Glycol in Air

Abstract A personal sampling and analytical method for ethylene glycol aerosol and vapor in air was developed and tested. The personal sampler contains a glass fiber filter followed by two sections of silica gel. Samples are analyzed by gas chromatography. Ethylene glycol vapor at concentrations ranging from 4.2 to 327 mg/m3 for 3-L air samples can be measured. Ethylene glycol can evaporate from the filter during air sampling at 25 °C and enter the silica gel tube.
Interaction between activated carbon and microorganisms in PACT process

A laboratory-scale powdered activated carbon treatment (PACT) process was conducted to treat the synthetic dye wastewater containing reactive brilliant blue KN-R (RBB). The pore structures of the PAC and molecular structure of the RBB were analysed. The influences of the biomass concentration and the PAC dosage on RBB removal were investigated in an activated sludge system. In addition, kinetic studies based on four fundamental models were investigated. Furthermore, theories about the microscopic dynamic interaction process of PACT were studied. A schematic process of the interaction between activated carbon and microorganisms in a PACT process was proposed. It was concluded that the enhanced treatment of dye wastewater by the PAC in activated sludge process was due to the immobilized microorganisms on the PAC and the bio-regeneration process.
Determining Ways of Controlling Unruly Students so as to Curb Destruction of School Building in Boarding Public Secondary Schools in Nyanza, Kenya

The research investigated ways of controlling unruly students so as to curb destruction of school building in boarding public secondary schools in Nyanza, Kenya. The concept of discipline should not be associated with pain or fear, but rather it should be viewed as a system of guiding the students to make reasonable decisions. Discipline in school and at home should be that which will produce young people who will be responsible when they become adults. The total number of teachers in affected public secondary schools at the time of the study was 102, 300 students and 50 school principals. A sample size of 150 of the following respondents was suitable for the study, that is 25 deputy principals, 100 students and 25 school principals. Data was collected through questionnaire and interviews. Validity and reliability of the instrument were established through expert opinion and Cronbach’s Alpha Coefficient of 0.80 reliability test respectively. Data was analyzed using Coefficient of Determination, Analysis of Variance, frequency counts and percentages. Ways of controlling unruly students so as to curb destruction of school building in boarding public secondary schools were: preventive type of discipline 33.3%, guidance and counseling 52.4% and application of both preventive and corrective means of discipline scored 47.6%. This study is significant in that it reveals the factors leading to unruly behavior and burning of school premises among boarding public secondary school students in Nyanza. The findings of this study would be useful to the Ministry of Education Science and Technology and the achievement of Kenya Vision 2030 in education.
Polyurethane-Keratin Membranes: Structural Changes by Isocyanate and pH, and the Repercussion on Cr(VI) Removal

Keratin has the capacity to interact with metal ions. In order to take advantage of this potential, a novel membrane with polyurethane and keratin has been developed and studied for removal of Cr(VI) from aqueous solution. Physicochemical and morphological properties of these hybrid membranes were studied, varying synthesis parameters such as the type of isocyanate and pH in keratin solution. The effects of using diphenyl-methane-diisocyanate or toluene-diisocyanate and modifying the pH in keratin solutions were evaluated by scanning electron microscopy, Fourier transform infrared spectroscopy, and dynamical mechanical analysis. Results show that pH has a strong influence on morphology and on Cr(VI) removal efficiency. When pH in keratin solution is low (2.5), the protein separates from water, and a more closed cell in the membrane is obtained affecting its mechanical properties. The removal efficiency of Cr(VI) was also assessed at different pH values of chromium solutions. These results show that when pH of the Cr solution is acidic (at 1.5), the Cr(VI) removal percentages increase significantly, reaching up to a 58%. Thus this paper demonstrates the successful combination of synthetic and natural polymers depending on the process parameters to be applied in the critical purpose of remediation of Cr(VI) contamination.
Determining the Separation Performance of the Knelson Concentrator

This study was aimed at determining the separation performance of the Knelson concentrator in Zonguldak fine coal (-1+0.15 mm). The experiments were carried out in the Knelson concentrator under the following optimal parameters determined in previous studies; water flow rate of 3.14 L/min., bowl speed of 459 rpm, solids ratio of 23.87%, and feed flow rate of 1.50 L/min. A series of tests were conducted at optimal test parameters to obtain enough samples for float and sink analysis. Clean coal and tailing products were subjected to float and sink analysis. Based on this analysis, partition curve for coal cleaning process was generated. The cut-point of the separation was obtained at the specific gravity of 1.72 [g/cm3]. The probable error (Ep) value, which signifies the efficiency of the process, was calculated as 0.11 These results indicated that Knelson concentrator is very effective in separating fine coal.
Atomic force microscopy at solid-liquid interfaces

An atomic force microscope (AFM) operating in force modulation mode is used to study solvation forces at the interface between a graphite (HOPG) surface and the liquids octamethylcyclotetrasiloxane (OMCTS) and n-dodecanol. Simple analytical models are used that adequately describe the response of the cantilever as the modulation frequency and tip−sample interaction change. The analysis of AFM force curves yields the tip−sample interaction stiffness and damping. Hydrodynamic damping is significant for all the levers used and at present this limits the sensitivity of detecting weak tip−surface damping effects. The main results are: (i) Confinement of liquid between two surfaces can lead to oscillatory structural forces even when one of the surfaces has very high curvature. This could influence topographic images at the atomic level in liquids. In these experiments the typical radius for a sharp AFM tip is measured as Rtip ≈ 14 nm. (ii) The effective viscosity increases by ∼4 orders of magnitude for a sharp.
Short Position Disclosures and Underlying Stock Performance: Evidence from Polish Stock Market

After introducing EU Regulation on short selling and certain aspects of credit default swaps, in 2012, investors holding a significant short positions are obliged to disclose it in a public manner, through the local supervisor registry. Beside the intended transparency, such a registry also have a cogent influence on behaviour of market participants. The Multimillion euros worth of short position is a strong view on underlying stock perspective, to say the least. Thus, many investors do care about the public disclosures of short positions and some of them manage their portfolios accordingly. The aim of herein paper is to provide quantitative assessment of stock performance following short position announcement and present activity of short selling investors on Polish stock market. The research hypothesis verified in this study stated that the prices of short sold stocks are exhibiting significant downward trend relative to the benchmark in a half a year period after disclosure.