Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlatos neurobiológicos de la terapia electroconvulsiva en pacientes con trastorno depresivo mayor estudio de neuroimagen multimodal

A pesar de los avances en la comprension de la fisiopatologia de la depresion, los tratamientos convencionales son solo parcialmente efectivos. En este contexto, la terapia electroconvulsiva (TEC) se convierte en un tratamiento alternativo eficaz para los pacientes con depresion resistente al tratamiento (DRT}. Con el objetivo de aportar una mejor comprension de las bases neurobiologicas de la TEC en pacientes con DRT la presente tesis incluye analisis longitudinales de: conectividad funcional (CF), trayectoria, morfometria cerebral, covarianza estructural y espectroscopia por resonancia magnetica. Los resultados indican que una disminucion temprana de la CF intralimbica predice un aumento posterior en la CF limbico-prefrontal, que a su vez predice la mejoria clinica de los pacientes con DRT al final de un ciclo de TEC. Estos resultados sugieren que la respuesta a la TEC implica cambios secuenciales en la CF limbico-prefrontal. Asimismo, la disminucion de la CF intralimbica podria constituir un biomarcador temprano de respuesta al tratamiento con TEC. Por otra parte, un aumento del volumen de sustancia gris (SG) en el lobulo temporal medial se asocio con una disminucion de N-acetil-aspartato hipocampal, un aumento de glutamato/glutamina hipocampal y una mejoria clinica significativa. En este sentido, diferentes cambios neuroplasticos y neuroinflamatorios pueden ser inducidos por la TEC y explicar su mecanismo de accion. Por ultimo, los incrementos del volumen de SG asociados con la TEC se observan especificamente de manera ipsilateral al(a los) hemisferio(s) estimulado(s) (TEC bilateral versus TEC unilateral derecha). Por tanto, los hallazgos neurovolumetricos de la presente tesis parecen relacionarse con la distribucion de la densidad de corriente subyacente a la disposicion de los electrodos. Ademas, la TEC bilateral fue mas efectiva que la TEC unilateral derecha. En este sentido, la mayor dispersion de la respuesta neuronal tras la estimulacion electrica parece dar lugar a mayores efectos clinicos antidepresivos.
Heavy metals concentration in the tissues of perch (Perca fluviatilis) and bleak (Alburnus alburnus) from Czarna Orawa River, Poland.

Two common fish species, Perca fluviatilis and Alburnus alburnus, from Czarna Orawa River were examined for concentration of certain heavy metals (Zn, Cu, Cd, Pb) in their tissues. Significant differences between these two species were indicated. It was found that they have accumulated 20.679 ± 3.151 μg/g and 35.109 ± 9.001 μg/g of Zn, 0.3277 ± 0.1185 μg/g and 0.5444 ± 0.1851 μg/g of Cu, 0.6229 ± 0.0806 μg/g and 0.7508 ± 0.0820 μg/g of Cd, and 0.4039 ± 0.1730 μg/g and 0.3710 ± 0.1179 μg/ of Pb, respectively. Results obtained were discussed in the context of previously conducted studies. Increased efforts in order to improve water quality of the Czarna Orawa River system are expected. Also consecutive further studies on other water organisms seem needed.
Functional genomics of methylated sulfur compound metabolism in Hyphomicrobium species

Methylated sulfur compounds (MSCs) are a group of organosulfur compounds with various roles in agriculture, industry, medicine and the biogeochemical sulfur cycle, making their microbial metabolism an important area of study. The overarching aim of this project has been to investigate the molecular mechanisms allowing bacterial species to metabolise MSCs by studying members of the methylotrophic Hyphomicrobium genus – namely Hyphomicrobium denitrificans ATCC51888, Hyphomicrobium methylovorum Bras1 and Hyphomicrobium sulfonivorans S1 - using a combination of genetics, genomics, proteomics and transcriptomics. These model Alphaprotoebacteria can utilise MSCs such as dimethylsuilfide (DMS), dimethylsulfoxide (DMSO), dimethylsulfone (DMSO2), methanesulfonic acid (MSA) and methanethiol (MT) as a sole source of carbon, sulfur and/or energy. At the project’s outset the mechanism Hyphomicrobium species use to degrade MSCs was thought largely understood, following the characterisation of a DMS oxidising DmoABtype DMS monooxygenase from Hyphomicrobium sulfonivorans S1 and a MT oxidising MtoX-type MT oxidase from Hyphomicrobium sp. VS, leading to the suggestion that Hyphomicrobium species first reduce DMSO2 and DMSO to DMS, then oxidise that DMS to hydrogen sulfide and formaldehyde via a MT intermediate. However, this study now indicates that Hyphomicrobium species actually contain two distinct pathways of methylotrophic MSC metabolism. The first is a putative DMSO2 oxidation pathway – proposed to contain the DmoAB and an SfnFG-type DMSO2 monooxygenase – that generates formaldehyde and sulfite via the intermediate MSA leading to sulfite adenylylation for sulfur excretion. The second is a putative DMS oxidation pathway – proposed to contain MtoX and an as yet-unidentified DMS oxidising enzyme – that generates and formaldehyde and hydrogen sulfite via a MT intermediate leading to thiosulfate oxidation via the SOX system. Furthermore, this study identifies an additional non-methyltrophic DMSO2 oxidation pathway in H. sulfonivorans that is specifically induced in response to sulfur starvation and capable of utilising DMSO2, DMSO, DMS and MSA as a sole sulfur source, even in the absence of a functional DmoAB-type DMS monooxygenase.
Understanding Lipid Oxidation in Low-Moisture Food

Overly high intake of saturated fat is an international problem contributing to global health issues. Low-moisture snacks account for a nutritionally significant proportion of the saturated fat in the diet, making these foods a key target for improving consumers’ health. However, it is not currently feasible to maintain the same oxidative shelf life when replacing saturated fats with unsaturated fats, which are generally perceived to be more heart-healthy. This article summarizes current theories and available research on lipid oxidation in low-moisture foods in order to lay the groundwork for new lipid oxidation rate-reduction strategies. Research deficits needing attention and new methods for assessing lipid oxidation in low-moisture foods are also discussed.
Effect of Gayatrimantra chanting on cognitive functions in school children

Background: In Indian tradition chanting of Vedic mantras is a part and parcel of life. The sacred Gayatri mantra was explained in Rig Veda. It was initially explained by Vishwamitra maharshi. As it is concerned about sun, it is also called as Savir mantra. Methods: Thirty healthy, willing, hostel students (15 boys and 15 girls) in the age group of 11-14 years were included in the study. After recording the baseline values, all the students were trained in Chanting Gayatri mantra for a week days by Veda pundit before the starting of the study. After a week days, the participants started chanting the mantra once a day, for five days a week, early in the morning at 6am under the supervision of Vedic expert for 10 minutes for16 weeks. Post intervention values were recorded after 16 weeks. Results: Results were presented in tabular form. There was a significant increase in the both spatial and verbal memory scores followed by the chanting of Gayatri mantra. Conclusion: The present study provides further evidence for the beneficial effects of chanting Gayatri mantra. We recommend further detailed studies in this area to understand molecular mechanisms involved.
NOVEL ADAPTIVE FILTERING TECHNIQUE FOR THE PROCESSING OF ELECTROGASTROGRAM

The electrogastrogram measured cutaneously by attaching electrodes to the abdominal skin contains considerable noise. An attempt is made to develop an efficient adaptive filtering technique suitable for real time processing of electrogastrogram. A novel technique combining both adaptive noise cancellation and adaptive signal enhancement in a single recurrent neural network is proposed. To compare its performance, adaptive noise cancellation and cascaded connection of adaptive noise cancellation and adaptive signal enhancement are employed. Recurrent neural networks using Real Time Recurrent Learning (RTRL) algorithm are employed for implementing the all the above systems. An attempt is made to alleviate the computational burden imposed by RTRL algorithm by employing pruning of weights.
Liposomes : a practical approach

Part 1 Introduction, R.R. C.New preparation of liposomes, R.R. C.New liposome characterization, R.R. C.New covalent attachment of proteins to liposomes, F.J.Martin physical methods of study, G.R. Jones and A.R. Cossins liposomes in biological systems, R.R. C.New et al. Appendices: miscellaneous methods manufacturers and suppliers standard texts of liposomes and phospholipid membranes.
Modelling the atmosphere of potential habitable planets

Abstract The list of planets discovered in the habitable zone of its star is continuously growing. We present a simple one-dimension radiative transfer model in order to better infer on the habitability of such systems. Particular focus is on the TRAPPIST-1 planets (Gillon et al. 2017), particularly on planets b, c, d, e and f.
Transforming research (and public engagement) through citizen science

Abstract Processing our increasingly large datasets poses a bottleneck for producing real scientific outcomes and citizen science - engaging the public in research - provides a solution, particularly when coupled with automated routines. In this talk we will provide a broad overview of citizen science approaches and best practices. We will also highlight in particular recent advances through Zooniverse, the world’s largest platform for online citizen science, engaging more than 1.7 million volunteers in tasks including discovering exoplanets, identifying features on Mars’ surface, transcribing artist’s notebooks, and tracking resistance to antibiotics.
Breeding success of the Great Cormorant, Phalacrocorax carbo Linnaeus, 1758, at Ramsar, northern Iran

Abstract Factors influencing the breeding success of the Great Cormorant, Phalacrocorax carbo Linnaeus, 1758, were studied in the 2003 breeding season at the Ramsar colony in northern Iran. The mean brood size was 3.03, and early-breeders had significantly larger broods than later breeders. However, no statistically significant difference was found in the reproductive success between early and late breeders. There was no significant relationship between nest size and number of chicks fledged. The mean productivity was 2.88 young per breeding attempt, which means about 80% of eggs laid produced nestlings that reached the fledging stage. Daily nest survival was higher in the chick-rearing stage than in the incubation period, and most failures (ca. 60%) occurred during the incubation period. The results suggest that the Ramsar colony provides more favourable nesting conditions for Great Cormorants than do some of the other colonies studied throughout its range.
Adaptação transcultural da Trinity Amputation and Prosthesis Experience Scales - Revised (TAPES-R)

A literatura aponta ausência de instrumentos específicos para avaliação clínica e pesquisa direcionada a pessoas com amputação, sendo a escala TAPES-R relevante para análise dos aspectos psicossociais nessa população. Esta escala foi desenvolvida para avaliar os processos envolvidos na adaptação à amputação de membros inferiores e à prótese. Este instrumento abrange 33 itens organizados em três domínios - ajustamento psicossocial, restrição de atividade e satisfação com prótese, além de questões relacionadas com a dor do membro fantasma e do membro residual. Objetivo: Realizar adaptação transcultural da escala TAPES-R para aplicação na população brasileira. Método: A adaptação transcultural foi realizada em cinco etapas: tradução, tradução reversa, síntese das avaliações, avaliação por comitê de especialistas e teste final na população. Foi realizada a comparação entre as versões original e traduzida em relação às equivalências semântica, idiomática, cultural e conceitual. A versão final foi aplicada em 116 sujeitos amputados de membros inferiores. Resultados: Houve clareza quanto à compreensão do instrumento pelos participantes, indicando que o mesmo esteja apropriado à realidade do público-alvo na população brasileira. Amputação acima de joelho e tempo de uso da prótese abaixo de 10 horas/dia estão associados a pior ajustamento e menor satisfação com a prótese. Conclusão: O uso da escala TAPES-R permitiu avaliar a percepção dos indivíduos acerca da experiência com a amputação e prótese, possibilitando o uso clínico para avaliação de resultados voltados para a reabilitação de pacientes com amputação de membro inferiores. Serão desenvolvidos novos estudos para a continuidade de validação do instrumento.
Estimation of the Population Sizes of Neuronal Types of the Hippocampome Knowledge Base in the Dentate Gyrus

iii Acknowledgments I would like to thank the following people who made this possible . Christopher Rees first and foremost, for being mind-bogglingly helpful and supportive during the writing process; for all of their hard work on the Hippocampome; and my advisor, Giorgio Ascoli, for welcoming me into neuroinformatics and teaching me so much.
Interstitial laser photocoagulation therapy for liver tumors: clinical results

Interstitial laser photocoagulation is a new technique of tumor ablation using low power (2 W) laser light over a long time (500 s) via thin (0.2 mm) optical fibers. We have treated 26 patients with 70 liver metastases measuring 1 to 15 cm (median 2.5 cm). There were 1 to 8 treatment sessions per patient (median 3). Each tumor was treated via 1 to 4 optical fibers. The median energy used was 16000 J (range 3000 to 34000 J). Treatment effects were monitored in real-time with ultrasound, and the extent of tumor necrosis evaluated 1 to 3 days later using dynamic enhanced CT which showed laser-induced necrosis as well-defined new areas of non-enhancement. Greater than 50% necrosis of tumor volume was achieved in 86% (60 out of 70) of the tumors treated, and 100% necrosis in 53% (37 out of 70). Metastases under 4 cm were treated more effectively and required fewer treatment sessions than those over 4 cm. In eleven patients there was evidence of disease progression (follow-up 14 months or longer) and in 15 patients there has been overall tumor reduction (follow-up less than 1 year, median 4 months). Conclusion: With further development, ILP may offer a practical and minimally invasive alternative to major surgery for eradicating small, deep seated tumors, and debulking larger ones.
Survey on Summarization Method and Timeline Generation of the Tweet

Recently tweeter is growing as one of the famous social networking sites among the users. It may be in the form of short messages with limited of words. Users shared the tweet among the other users. More than 400 million tweets are received by the tweeter. Tweets contain different types of data that might be reviews or opinions on certain topic, some discussions, news, discussion on problems and solutions, blogs and more. In this paper we survey about the different technique used for extracting tweet and generating summary from the tweet. In this paper we discussed about the different summarization algorithms, and techniques used for timeline generation.
Acquisition of renogenic competence in the early mouse embryo and embryonic stem cells

xi Declaration.xiii Acknowledgments.xiv List of abbreviations.xvi List of figures and tables.xxi Chapter 1: Introduction to embryo development, kidney development and stem cell biology 1.1 Aims.2 1.2 Chapter introduction.3 1.3 The kidney – function and anatomy.4 1.4 Development.8 1.4. 1 Mouse embryonic development.9 1.4. 1.1 Early embryo development.9 1.4. 1.2 Mesoderm.12 1.4. 1.3 Intermediate mesoderm.14 1.4. 2 Kidney development.15 1.4. 2.1 The nephric duct.16 1.4. 2.2 The pronephros.18 1.4. 2.3 The mesonephros.19 1.4. 2.4 The metanephros.20 1.5 Important genes expressed during embryonic kidney development and nephron formation.24 1.6 Embryonic stem cells.30 1.6. 1 The biology of embryonic stem cells.30 1.6. 1.1 Characteristics of embryonic stem cells.32 1.6. 1.2 The discovery of embryonic stem cells.33 1.6. 1.3 How is pluripotency maintained? 34 1.6. 1.4 Other types of stem cells.36 1.6. 2 Embryonic stem cell differentiation to a renal lineage – a literature
Identification of zinc binding proteins of wheat seed

Zinc content of the wheat seed has significance for agronomy, environment and also for human health. Seeds containing higher amounts of micronutrients, especially zinc, are better at germination and show high resistance to pests. Experiments on the mechanisms of micronutrient uptake and their accumulation in the plant body and the seeds showed a correlation between zinc and protein amount in the seed, which suggested some proteins, mostly abundant in the embryo and the aleurone layer, might be sinks for zinc. There is a lack of knowledge on zinc binding proteins of wheat seed. In this project, we aimed to determine the effect of environmental conditions on the protein and micronutrient content of the durum wheat seed and to screen the proteome of the wheat seed to identify the proteins with metalin particular Zn-binding propensity. Protein analyses were carried out on seeds with extreme N and Zn content. Extraction methods available in the literature were modified to obtain reproducible profiles of the total protein content and to separate seed proteins into fractions of different storage protein classes. Extracts were analyzed using polyacrylamide gel electrophoresis and a procedure for detection of Zn-binding proteins was developed. Results showed Zn-binding by Cys rich proteins in the molecular mass range 30 to 50 kDa. The method was extensively tested to confirm the association of Zn with specific proteins, however, if those proteins bind metal in vivo remains to be shown. Microscopic analysis of in situ staining for protein and Zn localization showed preferential staining in the embryo and aleurone layers of the seed and led to determination of the protein profiles from embryo and endosperm tissues, separately. The methods developed during this and further studies, shall be used to do the same screening for different wild-type and cultivated genotypes of wheat.
Distribution, severity, and relative importance of leaf spot diseases of wheat in western Canada in 1974.

The leaf spot diseases spot blotch [Bipolaris sorokiniana], tan spot [Drechslera tritici-repentis], and speckled leaf blotch [Septoria avenae f. sp. triticea] caused insignificant damage to wheat (Triticum aestivum and T. durum) in western Canada in 1974, although infections were widespread. Spot blotch and tan spot occurred commonly in Manitoba and Saskatchewan but were rare in Alberta. Speckled leaf blotch, the least common disease, was found in all three provinces. Artificial inoculations indicated that spot blotch symptoms were distinguishable from those of tan spot and speckled leaf blotch, but that symptoms of the last two diseases were difficult to differentiate. Tan spot and speckled leaf blotch killed infected leaves within 2 1 days. The widespread distribution and potential for foliar damage of D. tritici-repentis indicate that it is the most important leaf spot pathogen of wheat in western Canada.
Implementasi Sensor Mpu 6050 untuk Mengukur Kesetimbangan Self Balancing Robot Menggunakana PID

Teknologi adalah suatu cara yang dapat dilakukan untuk menjadikan hidup lebih cepat, dinamis dan menyenangkan. Salah satu teknologi yang berkembang pesat saat ini adalah teknologi dibidang robotika. Self Balancing Robot (robot penyeimbang) beroda dua merupakan suatu robot mobile yang tidak akan seimbang apabila tanpa adanya kontroler. Robot akan maju mundur untuk mendapatkan keseimbangan. Untuk mendapatkan kesetimbangan yang baik maka diperlukan sensor keseimbangan yang memiliki sentivitas yang bagus. Sensor MPU 6050 merupakan sensor keseimbangan yang sudah dilengkapi oleh sensor Accelerometer dan Gyroscope yang mampu membaca sudut kemiringan pada tiga variable sekaligus, yaitu x,y dan z. Algoritma PID akan membantu sensor dalam menyeimbangkan robot dimana komponen Kp, Ki dan Kd akan secara real time mengirim sinyal kepada sensor. Robot ini mampu berdiri tegak dibidang datar dengan posisi sudut kemiringan awal -20 0 sampai 20 0 . Nilai manual tuning ideal pada robot ini adalah Kp 70, Kd 250 dan Ki 1.9. Semakin berat dan tinggi mekanik robot maka manual tunning PID harus ditigkatkan juga.
Interconnection between Winds and Sea Level in the Western Black Sea Based on 10 Years Data Analysis from the Climate Change Perspective

The relationship between the annual wind records from Romanian shore weather station and annual mean sea level, is examined using observations covering period 2006 - 2016. It is demonstrated that even such a relatively short record is sufficient for finding a convincing relationship. Using measured data from a weather station is found to give a slight improvement over reanalysis data, but for both the correlation between annual mean sea level and wind energy in the west–east direction is high. Supplementary data from a numerical hydrodynamic model are used to illustrate the regional variability in annual mean sea level and its interannual variability at a high spatial resolution. Recent climate change and land uplift are causing changes in sea level. This study implies that climatic changes in the strength of winds from a specific direction may affect local annual mean sea level quite significantly. Water levels at a particular location are not only affected by the local air pressure but also by other factors, so this simple correlation is rarely observed. Using 10 years (2006 - 2016) of Constanta - Romania coastal sea-level observations, we examine the contribution of these latter processes to long-term sea-level rise, which, to date, have been relatively less explored. A specific analysis and to evidence the correlation between wind pattern and sea level, the 2014 is chosen due to the frequent western winds that occurred during January and August in the Romanian Black Sea coast.
Tamanho de amostra para a estimação do coeficiente de correlação linear de Pearson entre caracteres de mamoneira

No estudo de relacoes lineares e importante dimensionar adequadamente a amostra para a estimacao do coeficiente de correlacao linear de Pearson entre pares de caracteres, com confiabilidade aceitavel. O objetivo deste trabalho foi determinar o tamanho de amostra (numero de plantas) para a estimacao do coeficiente de correlacao linear de Pearson entre 21 caracteres de mamoneira. Foram avaliadas 41 e 55 plantas dos hibridos Sara e Lyra, respectivamente, quanto aos caracteres de semente, de plântula, de planta adulta e de producao, em Santa Maria, Estado do Rio Grande do Sul, no ano agricola de 2007/2008. Calculou-se o tamanho de amostra por meio de reamostragem “bootstrap”, para a estimacao do coeficiente de correlacao linear de Pearson, para as amplitudes do intervalo de confianca de “bootstrap” de 95% iguais a 0,20, 0,35 e 0,50, para cada um dos 210 pares de caracteres. Independentemente do hibrido de mamoneira, 96 plantas sao suficientes para a estimacao do coeficiente de correlacao linear de Pearson, para a amplitude do intervalo de confianca de “bootstrap” de 95%, maxima de 0,52.