Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimization driven kinematic control of constrained collaborative mobile agents with high mobility

Industrial robots, in particular serial industrial manipulators, have enabled a lot of recent research in large scale robotic systems such as used in construction robotics, robotics in architecture. However, industrial manipulators have very low payload to weight ratio, are too generic systems with inflexible hardware and software for task adaptability. High mobility large scale robotic systems often involve even heavier mobile bases to move around these industrial manipulators, thus even further lowering the payload to weight ratio of such systems. Moreover, such system architecture is inflexible and eventually reaches its limits when higher mobility is demanded such as higher overall reach with same payload. This paper presents a concept of constrained collaborative mobile agents where the actuated mobile agents are constrained by a passive kinematic structure whose topology can be inexpensively configured according to different functions, task and mobility requirements. The type and number of mobile agents, the choice of actuation scheme are other important characteristic of this system which can be altered to improve system performance. A novel optimization framework for modeling and kinematic control of such systems is presented which is flexible to the above-mentioned system elements and characteristics. Finally, two prototypes are presented which are used to demonstrate the optimization driven kinematic control of the system with different topologies.
Postoperative Critical Events Associated With Obstructive Sleep Apnea: Results From the Society of Anesthesia and Sleep Medicine Obstructive Sleep Apnea Registry.

BACKGROUND Obstructive sleep apnea (OSA) patients are at increased risk for pulmonary and cardiovascular complications; perioperative mortality risk is unclear. This report analyzes cases submitted to the OSA Death and Near Miss Registry, focusing on factors associated with poor outcomes after an OSA-related event. We hypothesized that more severe outcomes would be associated with OSA severity, less intense monitoring, and higher cumulative opioid doses. METHODS Inclusion criteria were age ≥18 years, OSA diagnosed or suspected, event related to OSA, and event occurrence 1992 or later and <30 days postoperatively. Factors associated with death or brain damage versus other critical events were analyzed by tests of association and odds ratios (OR; 95% confidence intervals [CIs]). RESULTS Sixty-six cases met inclusion criteria with known OSA diagnosed in 55 (83%). Patients were middle aged (mean = 53, standard deviation [SD] = 15 years), American Society of Anesthesiologists (ASA) III (59%, n = 38), and obese (mean body mass index [BMI] = 38, SD = 9 kg/m); most had inpatient (80%, n = 51) and elective (90%, n = 56) procedures with general anesthesia (88%, n = 58). Most events occurred on the ward (56%, n = 37), and 14 (21%) occurred at home. Most events (76%, n = 50) occurred within 24 hours of anesthesia end. Ninety-seven percent (n = 64) received opioids within the 24 hours before the event, and two-thirds (41 of 62) also received sedatives. Positive airway pressure devices and/or supplemental oxygen were in use at the time of critical events in 7.5% and 52% of cases, respectively. Sixty-five percent (n = 43) of patients died or had brain damage; 35% (n = 23) experienced other critical events. Continuous central respiratory monitoring was in use for 3 of 43 (7%) of cases where death or brain damage resulted. Death or brain damage was (1) less common when the event was witnessed than unwitnessed (OR = 0.036; 95% CI, 0.007-0.181; P < .001); (2) less common with supplemental oxygen in place (OR = 0.227; 95% CI, 0.070-0.740; P = .011); (3) less common with respiratory monitoring versus no monitoring (OR = 0.109; 95% CI, 0.031-0.384; P < .001); and (4) more common in patients who received both opioids and sedatives than opioids alone (OR = 4.133; 95% CI, 1.348-12.672; P = .011). No evidence for an association was observed between outcomes and OSA severity or cumulative opioid dose. CONCLUSIONS Death and brain damage were more likely to occur with unwitnessed events, no supplemental oxygen, lack of respiratory monitoring, and coadministration of opioids and sedatives. It is important that efforts be directed at providing more effective monitoring for OSA patients following surgery, and clinicians consider the potentially dangerous effects of opioids and sedatives-especially when combined-when managing OSA patients postoperatively.
Differential expression of proteoglycan epitopes by ovine intervertebral disc cells

The alginate bead culture system has been utilised by several groups to examine the in vitro proteoglycan (PG) metabolism of chondrocytes and intervertebral disc cells, but the nature of the PGs produced has not been examined in detail. This is largely due to the difficulty of separating the anionically charged sodium alginate support matrix from PGs which are similarly charged. In the present study ovine annulus fibrosus, transitional zone and nucleus pulposus cells were dissociated enzymatically from their respective matrices by sequential digestion with pronase/clostridial collagenase and DNAase and then cultured in alginate beads for 10 d. The beads were solubilised and subjected to DEAE Sepharose CL6B anion exchange chromatography to separate the sodium alginate bead support matrix material quantitatively from the disc cell PGs. The alginate free bead PGs were then subjected to composite agarose polyacrylamide gel electrophoresis to resolve PG populations and the PGs were transferred to nitrocellulose membranes by semidry electroblotting. The PGs were identified by probing the blots with a panel of antibodies to defined PG core protein and glycosaminoglycan side chain epitopes. Alginate beads of disc cells were also embedded in paraffin wax and 4μm sections cut to immunolocalise decorin, biglycan, versican, and the 7‐D‐4 PG epitope within the beads. Decorin and biglycan had similar distributions in the beads, being localised on the cell surface whereas versican and the 7‐D‐4 PG epitope were immunolocalised interterritoriarly. This study is the first to demonstrate that ovine disc cells synthesise versican in alginate bead culture. Furthermore the immunoblotting studies also showed that a proportion of the 7‐D‐4 PG epitope was colocalised with versican.
The Parenting Education Needs of Women Experiencing Incarceration in South Australia: Proposal for a Mixed Methods Study

Background The mother-child relationship is extremely important, and for mothers experiencing incarceration, this relationship has unique challenges. There is limited evidence currently available to identify the type and content of parenting education that would best suit women who are incarcerated. Objective This study aims to design and evaluate a parent education program for women experiencing incarceration in South Australia. The program must meet the specific needs of incarcerated women and considers the cultural needs of Aboriginal and or Torres Strait Islanders and migrant women. Hereafter Aboriginal and/or Torres Strait Islander peoples will be referred to as Aboriginal; the authors acknowledge the diversity within Aboriginal cultures. Methods This study will utilize a mixed methods approach, including six phases framed by a community-based theoretical model. This methodology provides a collaborative approach between the researcher and the community to empower the women experiencing incarceration, allowing their parenting education needs to be addressed. Results A scoping review was undertaken to inform this study protocol. This paper describes and discusses the protocol for this mixed methods study. Recruiting commenced in December 2019, results will be published in 2020, and the project will be completed by August 2022. This project has been supported by a Research Training Scholarship from the Australian Government. Conclusions The scoping review highlighted a lack of rigorous evidence to determine the most appropriate parenting education program to suit women experiencing incarceration specifically, and there was little consideration for the cultural needs of women. It also became clear that when quantitative and qualitative data are utilized, the women’s voices can assist in the determination of what works, what will not work, and what can be improved. The data collected and analyzed during this study, as well as the current evidence, will assist in the development of a specific parenting education program to meet the needs of women experiencing incarceration in South Australia and will be implemented and evaluated as part of the study. International Registered Report Identifier (IRRID) PRR1-10.2196/18992
Effect of heavy metal pollutants on sunflower

The aim of this present study was to assess the tolerance of pollutant elements (Co, Ni, Cd, Cr and Pb) on visible foliar symptoms, tissue concentration and some biochemical parameters in sunflower plants grown at 0.25 mM in soil pot culture. At equimolar concentrations (0.25 mM), Cd induced the most severe visual toxicity effects and exhibited maximum oxidative damage as observed by accumulation of ThioBarbituric Acid Reactive Substances (TBARS) and lower antioxidant capacity than the plants is exposed to Co, Cd, Cr and Pb. The study suggests that the degree of oxidative damage assessed by the manifestation of external visual toxicity effects, tissue concentration and alteration in biochemical parameters were found to be in the order Cd>Cr>Ni>Co>Pb.
Numerical simulations of winter cold damage to citrus fruits using the WRF model

Abstract. To numerically assess winter cold damages of citrus fruits, a cold duration of sub-zero temperature was simulated using a high resolution configuration (500 m horizontal grid spacing) of the WRF numerical weather prediction system. Japanese citrus is often cultivated on slopes made of a small hill and a valley. Hence, a high resolution spatial configuration is needed to simulate cold durations at complex micro-topographies. In this study, detailed cold duration maps for sub-zero temperatures were produced to assess the spatial difference of cold duration, as an example of a winter cold surge attack in west Japan in 2011. Our findings suggest that the recorded temperature (by automatic observation of the Japan Meteorological Agency), which was observed at a flat coastal plain, may underestimate cold damage risk for citrus fruit on narrow slopes, valleys and hilly areas.
JEREMIAH METZGER LECTURES.

1964 JOHN EAGER HOWARD, M.D. Urinary Stone. 1965 GRANT W. LIDDLE, M.D. Analyse Circadian Rhythms of Adrenal Secretions. 1966 JOHN P. MERRILL, M.D. What Can We Do for the Patient with Renal Failure? 1967 STEWARD WOLF, M.D. Neural Mechanisms in Sudden Cardiac Death 1968 ROBERT W. WILKINS, M.D. Clinical and Climatological Observations of Hypertension. 1969 JAMES B. WYNGAARDEN, M.D. The Pathophysiology of Hyperuricemia in Gout. 1970 A. McGEHEE HARVEY, M.D. Myasthenia Gravis-The First 100 Years of Perspective. 1971 MARVIN D. SIPERSTEIN, M.D., PH.D. The Relationship of Cholesterol Biosynthesis to Cancer. 1972 GEORGE F. CAHILL, JR., M.D. Ketosis. 1973 RICHARD B. HORNICK, M.D. Salmonella Infections-Newer Perspectives of an Old Infection. 1974 JACQUES GENEST, M.D. The Renin-Angiotensin System. 1975 VICTOR A. McKusICK, M.D. New Genetic Insight into Old Diseases. 1976 ROBERT M. BIRD, M.D. Information Transfer in the Service of Medicine. 1977 ROBERT AUSTRIAN, M.D. Of Gold and Pneumococci. 1978 CARL W. GOTTSCHALK, M.D. The Nephrons in Bright's Disease: Their Structure and Function. 1979 SHELDON M. WOLFF, M.D. The Pathogenesis of Fever in Human Subjects. 1980 CHARLES C. J. CARPENTER, M.D. Myths, Mandarins and Molecules: The Cautionary Tale of Cholera. 1981 LEIGHTON E. CLUFF, M.D. The Climate of Patient Care and Medical Education. 1982 DANIEL D. FEDERMAN, M.D. The Determinants of Human Sexuality. 1983 PURNELL W. CHOPPIN, M.D. Membrane Proteins and Virus Virulence. 1984 JACK M. GWALTNEY, JR., M.D. Climatology and the Common Cold. 1985 LoUIS TOBIAN, M.D. High Potassium Diets Strongly Protect Against Stroke Deaths and Renal Disease: A Possible Legacy from Prehistoric Man. 1986 RICHARD S. Ross, M.D. Thrombolysis and Dilatation in Coronary Occlusion. 1987 WILLIAM N. KELLEY, M.D. AND THOMAS D. PALELLA, M.D. Current Status of Human Gene Therapy. 1988 JOHN A. OATES, M.D. Participation of Eicosanoids in the Syndromes of Myocardial Ischemia. 1989 DAVID G. NATHAN, M.D. The Regulation of Hematopoiesis by Growth Factors. 1990 MICHEL CHRETIEN, O.C. , M.D. From POMC to Functional Diversity of Neural Peptides: The Key Importance of Convertases. 1991 GERALD L. MANDELL, M.D. Microbial Defenses Against Killing by Phagocytes. 1992 JEREMIAH A. BARONDESS, M.D. The Future of Generalism.
A knowledge-based approach for automatic quantification of epileptiform activity in children with electrical status epilepticus during sleep

Objective. Electrical status epilepticus during sleep (ESES), as electroencephalographic disturbances, is characterized by strong activation of epileptiform activity in the electroencephalogram during sleep. Quantitative descriptors of such epileptiform activity can support the diagnose and the prognosis of children with ESES. To quantify the epileptiform activity of ESES, a knowledge-based approach to mimic the clinical decision-making process is proposed. Approach. Firstly, a morphological operations-based scheme is designed to quickly locate the positive peaks/negative pits and roughly estimate the onset/offset of spike and slow-wave abnormalities. Then, to provide the accurate duration of ESES patterns, a set of rules for further adjusting these onsets/offsets are proposed by merging medical knowledge with a generalized threshold obtained from statistics. As such, the quantification is accomplished by evaluating the obtained spike and slow-wave abnormalities and their various durations. Main results. The effectiveness and feasibility of the proposed method were evaluated on a clinical dataset that collected at Children’s Hospital of Fudan University, Shanghai, China. We demonstrate that the proposed method can recognize different types of spike and slow-wave abnormalities. The sensitivity, precision, and false positive rate achieved 91.96%, 97.09%, and 1.88 min−1, respectively. The estimation error for the spike-wave index was 2.32%. Comparison results showed that our method outperforms the state-of-the-art. Significance. The quantification of spike and slow-waves provides information about ESES activity. The detection of variations types of spike and slow-waves improves the performance in the quantification of ESES. Experimental results suggest that the proposed method has great potential in automatic ESES quantification and can help improve the diagnosis and researches of epileptic encephalopathy with ESES.
Reusable Magnetic Nanoparticle Immobilized Nitrogen-Containing Ligand for Classified and Easy Recovery of Heavy Metal Ions

Functionalized Tris[2-(dimethylamino) ethyl] amine (Me6TREN) ligands tethered-Fe3O4@Me6TREN nanoparticles (NPs) with a size of 150 nm were prepared to achieve classified and easy recovery of heavy metal ions in wastewater. The preparation of such NPs related to sequential silane ligand exchange and a following cure and Schiff base reactions for Fe3O4 NPs. Fe3O4@Me6TREN NPs as an effective nano-adsorbent of heavy metals exhibited significant differences in maximum adsorption capacity for Cr(III) (61.4 mg/g), Cu(II) (245.0 mg/g), Pb(II) (5.3 mg/g), and Cd(II) (1136.2 mg/g), in favor of classified removal of heavy metals from wastewater. Furthermore, Fe3O4@Me6TREN NPs can be regenerated by desorbing metal ions from NP surfaces eluted with ethylenediaminetetraacetic acid disodium salt (EDTA-Na2) aqueous, which endows such NPs promising potency as new nano-vectors for the removal of heavy metals.
Making semantic commitments can be delayed: Evidence from aspectual processing.

Semantic interpretation of aspectual verbs has been shown to cause a processing cost. The present study provides additional evidence that the semantic interpretation of events interacts with sentence processing. The study focused on telicity, an aspectual property that does not solely depend on lexical items but instead on the semantic composition of verb phrase (VP)-level events. Results from a working memory task showed that committing to a semantic interpretation incurs a processing cost and that some adverbials force the parser to commit to a particular aspectual interpretation. Specifically, in-X-time adverbials force the parser to commit to a telic (completed/terminated) interpretation before the VP has been processed. In contrast, for-X-time adverbials, which are compatible with an atelic (completed or incomplete) interpretation, do not force the parser to make an early commitment to a particular semantic interpretation. Instead, processing is always delayed until the VP has been completely parsed. Results support the partial interpretation hypothesis according to which the parser can delay making semantic commitments until it is necessary to do so, that is, in atelic but not telic sentences. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
Reproduction and development of two angel sharks, Squatina squatina and S. oculata (Pisces: Squatinidae), off Tunisian coasts: semi-delayed vitellogenesis, lack of egg capsules, and lecithotrophy

Distribution, sexual maturity, fecundity, genital asymmetry, cyclic vitellogenesis and gestation are described in the angel sharks Squatina squatina (L., 1758) and S. oculata Bonaparte, I840 from Tunisian waters. With embryonic nutrition being purely lecithotrophic, lack of egg capsules, block of oocyte growth at the beginning of gestation, and inability to ovulate soon after parturition, Squatinidae can be compared to Torpedinidae and to Centroscymnus (Squalidae), except that their vitellogenesis starts again at mid-gestation. This new, special feature has been termed ‘semi-delayed vitellogenesis’ with regard to the delayed vitellogenesis of Torpedinidae and Centroscymnus.
The association of myelination in the internal capsule with iron deposition in the basal ganglia in macaques: a magnetic resonance imaging study.

Background Iron plays a vital role in myelin synthesis and maintenance. A tight association between iron concentration and myelin content has been demonstrated in local brain regions; however, whether such a relationship exists between distant brain regions that are anatomically connected is largely unknown. Methods We conducted an in vivo measurement of iron and myelin content in the brains of 8 young (mean age: 7.7 years) and 8 old (mean age: 24.7 years) macaques by integrating two MRI-based techniques: quantitative susceptibility mapping (QSM) and myelin water fraction (MWF) imaging. We examined the relationship between iron deposition in components of the basal ganglia (BG), and the myelin content of the BG-connecting fiber tract internal capsule (IC) and four more white matter (WM) structures, including the optic tract, and the genu, body, and splenium of the corpus callosum, which are anatomically separate from the BG. Results Spearman's correlation analysis revealed a moderate to high (r=0.528-0.808, P<0.05) positive correlation between the magnetic susceptibility of the BG and the MWF of anatomically connected IC structures during myelin production and maintenance, but little significant correlation was found between the susceptibility of the BG and the MWF of WM structures not anatomically connected to the BG. Conclusions These results advance the understanding of the relationship between iron and myelin, and suggest that future studies should consider the impact that iron concentration in the BG has on the myelination of WM structures that are anatomically connected to the BG.
Positive information facilitates response inhibition in older adults only when emotion is task-relevant

ABSTRACT Emotional information is integral to everyday life and impacts a variety of cognitive abilities including response inhibition, a critical skill for maintaining appropriate and flexible behaviour. However, reported effects of emotion on response inhibition are inconsistent in younger adults, and very limited in older adults. Effects of aging are especially relevant because emotion regulation improves with aging despite declining inhibitory control over neutral information. Across three studies, we assessed the impact of emotional facial expressions on response inhibition in younger and older adults while manipulating attention to task stimuli. Emotional faces (versus neutral faces) altered response inhibition only when task instructions required explicit attention to emotional attributes of the faces. When directly comparing fear faces to happy faces, both age groups had better response inhibition to happy faces. Age further influenced differences across conditions, in that happy faces enhanced response inhibition relative to neutral faces in older adults but not younger adults. Thus, emotional response inhibition for task-relevant (but not task-irrelevant) positive information is enhanced in late life compared to early adulthood. The present work extends the nascent literature on emotional response inhibition in aging, and proffers a framework to reconcile the mixed literature on this topic in younger adults.
MRP.py: A Parametrizer of Post-Translationally Modified Residues

MRP.py is a Python-based parameterization program for covalently modified amino acid residues for molecular dynamics simulations. Charge derivation is performed via an RESP charge fit, and force constants are obtained through rewriting of either protein or GAFF database parameters. This allows for the description of interfacial interactions between the modifed residue and protein. MRP.py is capable of working with a variety of protein databases. MRP.py's highly general and systematic method of obtaining parameters allows the user to circumvent the process of parameterizing the modified residue-protein interface. Two examples, a covalently bound inhibitor and covalent adduct consisting of modified residues, are provided in the supporting information.
Exploring Associations Between Metabolites and Symptoms of Fatigue, Depression and Pain in Women With Fibromyalgia

Fibromyalgia (FM) is a chronic noncommunicable disorder characterized by a constellation of symptoms that include fatigue, depression and chronic pain. FM affects 2%–8% of the U.S. population, 2% of the global population, with 61%–90% of FM diagnoses attributed to women. Key causal factors leading to the development and severity of FM-related symptoms have not yet been identified. The purpose of this article is to report relationships among identified metabolites and levels of fatigue, depression, pain severity, and pain interference in a sample of 20 women with FM. In this secondary analysis, we conducted global metabolomic analysis and examined the data for relationships of metabolite levels with self-reported symptoms of fatigue, depression, pain severity, and pain interference. Results revealed six metabolites (6-deoxy-hexose; pantothenic acid; ergothioneine; l-carnitine; n-acetylserotonin; butyrobetaine) and their associated metabolic pathways such as carnitine synthesis, lipid oxidation, tryptophan metabolism, beta-alanine metabolism and pantothenic and Coenzyme-A biosynthesis that were either positively or inversely related to pain severity, pain interference, or both. The preliminary data presented suggest that metabolites representing energy, amino acid, or lipid classification may be associated with pain symptom severity and interference in women with FM. Future work will confirm these findings in a large, comparative cohort, targeting metabolites and metabolite pathways to better understand the relationships of metabolites and symptomology.