Miracle-dz/UniFAR-FTUs huggingface dataset:
Genetic analysis of the DAZ1 transcription factor in Arabidopsis thaliana

The aim of this research was to advance understanding of the molecular and genetic mechanisms by which the transcription factor, DAZ1 (DUO1-ACTIVATED ZINC FINGER 1) supports male germline development in Arabidopsis thaliana. The main approach was to analyse the importance of different protein domains in DAZ1 for generative cell division and pollen fertility. The DAZ1 basic region (BR), the DAZ1 conserved region (CR) and the role of individual zinc finger (ZnF) motifs were investigated. In planta complementation of mutant Arabidopsis daz1-/- daz2+/- plants with deletion and substitution variants of DAZ1 revealed important functional roles for the BR, CR and for ZnF3 in male germline development. DAZ1 variants with BR or CR mutations showed a significant but limited ability to rescue male germ cell division and transmission of daz1 daz2 pollen. A second objective was to study the cause of unexpected seed abortion observed in daz1-/- daz2-/- mutants that express DAZ1 variants with reduced function. Observations revealed ovule enlargement without development of embryo or endosperm tissues indicating early post-fertilisation defects arising from defective gametes. In a third objective, a genetic screen was conducted in Arabidopsis for suppressors of reduced fertility in chemically mutagenised plants expressing a C-terminally truncated DAZ1. Several suppressor lines were identified which were stably maintained through multiple generations. Overall, these studies uncover the importance of protein domains which support the role of DAZ1 in male germline development. This work also generated putative genetic suppressors which could provide access to novel regulators that orchestrate germ cell division and sperm differentiation in Arabidopsis.
Incorporating Expert-Based Investment Opinion Signals in Stock Prediction: A Deep Learning Framework

Investment messages published on social media platforms are highly valuable for stock prediction. Most previous work regards overall message sentiments as forecast indicators and relies on shallow features (bag-of-words, noun phrases, etc.) to determine the investment opinion signals. These methods neither capture the time-sensitive and target-aware characteristics of stock investment reviews, nor consider the impact of investor's reliability. In this study, we provide an in-depth analysis of public stock reviews and their application in stock movement prediction. Specifically, we propose a novel framework which includes the following three key components: time-sensitive and target-aware investment stance detection, expert-based dynamic stance aggregation, and stock movement prediction. We first introduce our stance detection model named MFN, which learns the representation of each review by integrating multi-view textual features and extended knowledge in financial domain to distill bullish/bearish investment opinions. Then we show how to identify the validity of each review, and enhance stock movement prediction by incorporating expert-based aggregated opinion signals. Experiments on real datasets show our framework can effectively improve the performance of both investment opinion mining and individual stock forecasting.
Low light levels increase avoidance behaviour of diurnal fish species: Implications for road culverts

Inadequately designed culverts are known to pose hydraulic barriers to fish passage, but they may also be behavioural barriers if they adversely affect light levels within them. To test this, we performed a choice experiment and quantified the amount of time individuals of four Australian fish species spent in darkened and illuminated areas of an experimental swimming fume. Behavioural responses were reflective of the species’ diel activity patterns; diurnal species preferred illuminated regions, while nocturnal species preferred the darkened region. We then determined a threshold light level of only ~100-200 lux (c.f. midday sunlight ~100,000 lux) was required to overcome the behavioural barrier in ~ 70% of the diurnal fish tested. Placing these threshold values into field context, 100% of culverts sampled recorded inadequate light levels. Attention is required to better understand the impacts of low light levels in culverts on fish passage and to prioritise restoration.
Hydrogeology of desert springs in the Panamint Range, California, USA: Identifying the sources and amount of recharge that support spring flow

Despite its location in the rain shadow of the southern Sierra Nevada, the Panamint Range hosts a complex mountain groundwater system supporting numerous springs which have cultural, historical, and ecological importance. The sources of recharge that support these quintessential desert springs remain poorly quantified since very little hydrogeological research has been completed in the Panamint Range. Here we address the following questions: (i) what is the primary source of recharge that supports springs in the Panamint Range (snowmelt or rainfall), (ii) where is the recharge occurring (mountain‐block, mountain‐front, or mountain‐system) and (iii) how much recharge occurs in the Panamint Range? We answer questions (i) and (ii) using stable isotopes measured in spring waters and precipitation, and question (iii) using a chloride mass‐balance approach which is compared to a derivation of the Maxey–Eakin equation. Our dataset of the stable isotopic composition (δ18O and δ2H) of precipitation is short (1.5 years), but analyses on spring water samples indicate that high‐elevation snowmelt is the dominant source of recharge for these springs, accounting for 57 (±9) to 79 (±12) percent of recharge. Recharge from rainfall is small but not insignificant. Mountain‐block recharge is the dominant recharge mechanism. However, two basin springs emerging along the western mountain‐front of the Panamint Range in Panamint Valley appear to be supported by mountain‐front and mountain‐system recharge, while Tule Spring (a basin spring emerging at the terminus of the bajada on the eastern side of the Panamint Range) appears to be supported by mountain‐front recharge. Calculated recharge rates range from 19 mm year−1 (elevations < 1000 mrsl) to 388 mm year−1 (elevations > 1000 mrsl). The average annual recharge is approximately 91 mm year−1 (equivalent to 19.4 percent of total annual precipitation). We infer that the springs in the Panamint Range (and their associated ecosystems) are extremely vulnerable to changes in snow cover associated with climate change. They are heavily dependent on snowmelt recharge from a relatively thin annual snowpack. These findings have important implications for the vulnerability of desert springs worldwide.
Development of Self-Exhibition Through Cognitive-Behavioral Counseling Models with Self-Management Strategies

This study aims to determine the effectiveness of cognitive-behavioral counseling models with selfmanagement strategies to develop a self-exhibition of state junior high-school students in Singaraja City. This type of research is a quasi-experimental research design with Nonequivalent Post-test Control Group Design that is research that uses intact groups. The study sample was 62 students who were determined using random sampling techniques by lottery. Data collection methods used were questionnaires and observations. Analysis of the data used in this study is the t-test. The analysis shows t-count (5.000) > t-table (2.00). The results showed that the cognitive-behavioral counseling model with an effective self-management strategy to develop a selfexhibition of state junior high-school students in Singaraja City. These results can be recommended to the teacher guidance and counseling to be an alternative assistance given to students to develop their potential and selfactualization such as self-exhibition to attract the attention of others.
Cetuximab-radiotherapy versus cetuximab-radiotherapy plus concurrent chemotherapy in patients with N0-N2a squamous cell carcinoma of the head and neck (SCCHN): Results of the GORTEC 2007-01 phase III randomized trial.

6003Background: Chemo-radiotherapy (CT/RT) and cetuximab-RT (cetux-RT) were established as standard treatments in non-operated locally advanced (LA) SCCHN. While the addition of cetux to cisplatin/RT offers no benefit as compared to the same CT/RT alone (RTOG 0522 trial), it was not known whether the addition of carboplatin/5FU to cetux-RT would improve outcome, as compared to cetux-RT alone. Methods: The GORTEC 2007-01 trial was restricted to patients (pts) with no or limited nodal spread (N0-N2a) and was run in parallel with GORTEC 2007-02 trial testing induction vs concurrent CT in N2b/c-N3 pts. Inclusion criteria were pts fit for receiving CT, non-metastatic, non-operated stage III-IV SCC of oral cavity, oro/hypopharynx and larynx. The 1:1 randomization between cetux-RT (arm A) and cetux-CT/RT (arm B) was done by minimization on centers, N and T stages. Cetux was given as a loading dose of 400 mg/m2 followed by weekly 250 mg/m2 during RT. RT total dose was 70 Gy (2 Gy/day, 5 days/week). Concurrent CT .
Cafés Especiais e Estratégias Regionais: (Im)Possível Articulação com “Cafés do Brasil”

“Cafes do Brasil” has many aromas, flavors, and experiences to be explored in the market. However, the dynamics valorization takes place in different contexts of production and coordination. The objective of this work was to identify the implications of different contexts of production and coordination on the institutionalization of “Cafes do Brasil” brand. Through content analysis, it was sought to capture resources and essential skills used in the strategic orientations from advertisements and from other information on sites of the collective organizations. The information was analyzed in Iramuteq software. It was observed that cooperatives are the driving force for new skills and capacities. It has built a coordination structure aimed at the defense of the local cafes in the market. This structure places producers and managers on a more accentuated learning curve that guides the building of strategies based on local resources. The diversity of contexts shows possibilities of links, strategies, concerns that guide actions and decisions, making it impossible to adopt a single marketing strategy for the whole chain.
SERUM ADIPONECTIN LEVEL IN OBESE AND NON OBESE TYPE 2 DIABETES MELLITUS

Back ground: Worldwide diabetes mellitus is no more an epidemic; rather it has turned into a pandemic health hazard. Association of obesity in type 2 diabetes mellitus is an established fact. This association could be partly mediated by altered secretion of adipokines by adipose tissue. Among all adipokines, adiponectin has been considered as an important factor in obesity induced insulin resistance. This new hormone produced exclusively by adipocytes differs from its predecessors in at least one important feature. While all of the other adipose tissue derived hormones related to insulin resistance are increased in obesity, adiponectin production and concentration actually decreases in obese subjects. Objective: the study was taken up to investigate the relationship between adiponectin in obese and non obese type 2 diabetes, and also to find out the correlation between adiponectin and serum lipids in urban south Indian population. Method: The cases chosen for the study group were already diagnosed cases of type 2 diabetes mellitus undergoing treatment. All subjects were interviewed regarding a full medical history that included age, sex, occupation, duration and family history of diabetes mellitus. The general physical examination procedure included measurement of height, weight, waist circumference and hip circumference. The biochemical parameters such as fasting plasma glucose, serum adiponectin, HDL and triglyceride were measured. Result: The reduction of serum adiponectin in study group was highly significant as compared to control group but its difference between the two subgroups divided based on BMI did not give a statistically significant result. But on correlation of BMI with adiponectin in study group, the correlation co-efficient was found to statistically highly significant. Similar correlation of waist-hip ratio (W/H) with adiponectin did not give a significant result. Conclusion: Adiponectin is lowered in obese non-diabetics affecting lipid metabolism showed by increase of LDL and TG and decrease of HDL. In obese diabetics adiponectin is high but dyslipidemia is still present possibly due to improper function of existing serum adiponectin.
Study on Fluid Movement Characteristics inside the Emitter Flow Path of Drip Irrigation System Using the Yellow River Water

Vigorously developing efficient water-saving agricultural technologies using the Yellow River Water is an important way to achieve sustainable use of water resources. In order to clarify the fluid movement characteristics inside the flow path of the emitter under complicated water quality conditions in a drip irrigation system using the Yellow River Water, the optimal simulation turbulence model for the flow field in the flow path of the emitter was determined by comparing the macroscopic hydraulic characteristics with the microscopic fluid motion characteristics of the fluid in the emitter. On this basis, the two-phase flow model was used to calculate and analyze the characteristics of water flow movement and particle transport in the emitter. The results show that the RNG (Re- normalization group) k-ε turbulence model was the most suitable for the simulation of the flow field in the emitter, considering the macroscopic hydraulic performance and microscopic anti-clogging ability of the emitter synthetically, and both the comprehensive calculation accuracy and the calculation efficiency. The pressure showed a step-like uniform decrease along the direction of water flow. The fluid flow showed the regional movement characteristics of the mainstream and non-mainstream regions. The energy dissipation mainly occurred at the sudden change sites of the flow path structure. The particle phase velocity was slightly lower than that of the water phase. The velocity at the near-wall surface was relatively lower than that at the center, and the velocity distribution along the depth direction of the flow path was relatively uneven. The sediment was mainly deposited in the first half of the flow path. This study can provide a theoretical basis for solving the emitter clogging in the drip irrigation systems applying water from the Yellow River.
Energy-Efﬁcient Resource Allocation for High-Rate Underlay D2D Communications With Statistical CSI: A One-to-Many Strategy

—For the prominent superiorities in energy and spectrum efﬁciency, Device-to-Device (D2D) communication has become a hot topic among the 5th generation (5G) technologies. However, the widely adopted mode that one or more D2D links reuse one cellular user‘s uplink spectrum may lead to severe limitation on D2D communication rate, especially when cellular user’s uplink spectrum is very limited. In this paper, we will face the high rate requirements of D2D pairs (DPs), with the help of carrier aggregation technology, each DP can reuse the uplink spectrum of multiple cellular users when needed. More practically, we consider that only statistical channel state information (CSI) of certain communication links is available here. Then, we formulate the problem to minimize the total power consumption of the mobile devices to obtain an energy-efﬁcient resource allocation result, including spectrum and power allocation. Meanwhile, the quality of service (QoS) requirements of cellular and high-rate D2D communications are both ensured. The formulated problem is mathematically a non-convex mixed-integer nonlinear programming (MINLP) problem, which is NP-hard. To solve it, we ﬁrst tighten the constraints and deploy transformation methods on it to make it convex. Then, we propose a two-layer algorithm, the independent-power greedy-based outer approximation (IPGOA), to solve the transformed problem. Besides, to handle the involved uniform power allocation circumstance in the carrier aggregation process, a uniform-power GOA (UPGOA) algorithm, which can be regarded as a simpliﬁed version of IPGOA, is also proposed. The simulation results show that in different scenarios, our proposed scheme is approximately optimal.
Epidermal growth factor receptor, vascular endothelial growth factor, mouse double minute 2 homolog, Ki 67, and p53 expression in glioblastoma: A survival analysis including the prognostic value of clinical, histopathological, and immunohistochemical parameters

Objective: The objective of the study was to describe the clinical, histopathological, and immunohistochemical profile of glioblastoma in patients and to correlate these findings with patient survival. Materials and Methods: Thirty cases of histopathologically diagnosed glioblastomas were included in this study. These cases were analyzed in detail for certain clinical and histopathological parameters. Immunohistochemical staining for p53, epidermal growth factor receptor, vascular endothelial growth factor, mouse double minute 2 homolog (MDM2), and Ki67 was done, and scores were calculated. Results of these findings were correlated with patient survival. Results: A retrospective analysis of the histopathology records and clinical case files was done in thirty cases of glioblastoma (World Health Organization Grade IV). The mean age of presentation was 50.6 years with a male predilection. The most common involved site was the frontal lobe. Among the clinical parameters, age of the patient and extent of surgical resection showed a significant correlation with the patient survival. Histopathological parameters showed no significant correlation with the patient survival, while among the immunohistochemical parameters, expression of MDM2 showed a significant correlation with the patient survival. Conclusion: In this study incorporating clinical, histopathological, and basic panel of immunohistochemistry, age of the patient, extent of the surgical resection, and expression of MDM2 showed a significant correlation with the patient survival.
Relevance of the Higher-Order Brand Love Prototype in a Service Context

Abstract A third-order composite model of brand love prototype is tested using Partial Least Squares (PLS) in a service consumption business: branded coffee outlets. Notable differences are found between the brand love prototype for products reported in literature and a service. The differences reside in the self-brand integration dimension, long-term relationship, and attitude valence. The self-brand integration dimension appears to carry little weight, compared to all the other dimensions of the brand love prototype, in the service. Consumers purchase products that self-enhance their own image, but for services, the self-brand integration may be more challenging to be perceived as relevant.
Orientation to guinea worm disease: a guide for use in pre-service and in-service training.

This orientation is aimed at all Peace Corps trainees assigned to endemic guinea worm areas. Its purpose is to help familiarize these trainees with the nature of guinea worm disease and to help them define the role they might play as Peace Corps volunteers (PCVs) in controlling or eradicating the disease in their communities. The orientation to guinea worn can be used in three possible training settings: Pre-Service Training: To make all pre-service trainees aware of the problem and of what they realistically might do to help during the first few months of service. In-Service Training: To increase PCVs appreciation of the guinea worm problem and to provide them with concrete plans for initiating secondary guinea worm projects in their communities. Training of Health / Water / Sanitation Volunteers: To serve as an introduction to the disease and to the roles of trainees whose primary assignments are either guinea worm disease-control water/sanitation or community health education. Further training would draw upon the skilltraining modules in Training Guide No. 3: Helping Communities to Eradicate Guinea Worm. (Excerpt)
Multiscale modelling of metallic nanoparticles' structural and catalytic properties

Nanoparticles are characterized by their small and finite-size. Indeed they are made of tens to thousands of atoms, corresponding to a size of 1 to tens nanometers. Nanoparticles’ finite-size entails three significant implications: internal transitional symmetry breaking occurs, electronic confinement effects are relevant, and nanoparticle’s surface to volume ratio is not neglegible. In turn, at the nanoscale, we witness: the occurrence of many peculiar structures, the arising of unique optical, magnetic, and catalytic properties (different from the one of the single atom and of its bulk counterpart) and characterized by peculiar structureproperty relationships, the failure of bulk thermodynamics modeling in the prediction of the nanoparticle structural stability, also for the case of relatively large systems. Indeed sizeand shape-effects are known to non-trivially affect the (meta)stability of a nanoparticle against melting and pre-melting. Borrowing the words spelt by Richard Feynman during his famous talk ’There is plenty of Room at the bottom’: "When we get to the very, very small world . we have a lot of new things that would happen that represent completely new opportunities for design. "[1] Tailoring the nanoparticles architecture i.e. size, shape, chemical composition and ordering at will, one could harness their full potential in technological devices which will trigger a revolution in many fields, ranging from biomedicine to catalysis and optics. The identification of optimal nanoparticle architectures for target purposes is, from here on, mentioned under the name of rational design. The complexity inherent to this practice represents a longstanding high-reward challenge as it hinges on the understanding of how each structural feature contributes towards the nanoparticle global chemophysical property. Moreover, the rational design of nanoparticles for target application should encompass the in depth study of the (meta)stability of the chosen bespoke nanoarchitecture. Indeed, coming back again to Feynman’s notorious contribution to nanoscience, he mentioned that ". [he was] not afraid to consider the final question as to whether, ultimately – in the great future – we can arrange the atoms the way we want; the very atoms, all the way down! (within reason, of course; you can’t put them so that they are chemically unstable, for example)". A degree of atomistic control of the nanoparticle components is currently at reach during both colloidal and physical growth methods. Thus, it is of fundamental importance
Exports Cause Outward Foreign Direct Investment in Indian Pharmaceutical Industry?

This article discusses the relationship among exports, outward FDI and total sales of Indian pharmaceutical industry. Aim is to analyze a two-way causal relationship among exports and outward FDI from Indian pharmaceutical market to understand whether exports and outward FDI are supplementary or complementary in nature. The article also aims to analyze how exports and outward FDI are affected by the lagged year’s values. The article illustrates the trend of exports and outward FDI from Indian pharmaceutical sector to draw an eclectic paradigm to study the impact of exports on outward FDI. A vector auto regression (VAR) model has been developed on exports and outward FDI, keeping total sales as exogenous variable using a lag of one and two years. The VAR model-substituted coefficients suggest that pharmaceutical exports are directly affected by last year Pharma OFDI. It was found that in context of Indian pharmaceutical sector, exports cause outward FDI and in turn previous year’s outward FDI has a direct impact on current year’s exports.