Miracle-dz/UniFAR-FTUs huggingface dataset:
Novel Application of 32P Brachytherapy: Treatment of Angiolymphoid Hyperplasia with Eosinophilia in the Right Auricle with 8-Year Follow-Up

Abstract Background: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a distinctive benign vascular disease that can be challenging to treat due to inconsistent results for various treatment modalities such as surgical excision, corticosteroids, radiotherapy, laser therapy, and other therapies, so novel approaches are needed to improve treatment outcomes. Materials and Methods: ALHE on the right auricle of a 54-year-old Chinese woman underwent brachytherapy using 32P simple drug membranes for five times. The 32P brachytherapy involving simple drug membranes of brachytherapy began by diluting a 32P solution with 0.9% NaCl solution to produce a radioactivity of 69.2–74.7 MBq/mL(1.87–2.02 mCi/mL). The drug membranes were removed between 48 and 72h after application. There were intervals ranging from 65 to 72d between the membrane application periods, and the last treatment was in June 2010. Results: After the 32P brachytherapy, follow-up results over the course of 8 years were promising. The regional symptoms disappeared, the right preauricular swelling decreased, the subcutaneous nodules decreased in size, the exudate disappeared, and the skin appearance improved. Conclusions: This case indicated that 32P brachytherapy may represent a novel ALHE treatment method that produces a favorable long-term outcome.
Phased helical antenna array design for CubeSat application

The following study investigates the feasibility of a low power, high speed downlink connection for the purposes of Cubesat application. Using a 2×2 phased helical antenna array operating on the 802.11b standard protocol with cots parts, a low cost 1U system is conceived with beam steering functionality and 11 Mb/s down link capability; unprecedented in traditional Cubesat communication links that are typically slow as a result of their strict power, size, and cost limitations. Applying a steerable antenna array also allows a small satellite to better maintain a secure link connection, directly forming the beam to the ground station, where a small, low-cost attitude control system (as usually found in CubeSats) would be unable to provide accurate physical antenna pointing. Due to time restraints, this paper only seeks to establish what is reasonably achievable in a CubeSat form factor, and to provide a rudimentary systems design and RF analysis for proving the feasibility of such a system. No hardware development or physical testing was done. The course of the study began with a review of previous work, defining 1U CubeSat limitations to set target goals for power consumption, physical size, overall cost, and downlink speed. From there a preliminary systems architecture was developed, which included high level design, component selection, frequency/protocol usage, and power and link budget analysis. Once establishing system capability, the design was further refined, creating and modelling the helical antenna design, MATLAB modelling the phased array behavior, and constructing and simulating a Wilkinson RF power divider board layout. The overall 1U CubeSat communication system design was determined to be able to theoretically transmit up to 11Mb/s downlink speeds using an 802.11b module in CCK mode, utilizing a 60 degree range for the steerable beam. The helical antennas, designed to operate at 2.4 GHz in a 2×2 configuration fit snugly on one 10cm × 10cm face of a CubeSat, and the one-to-four RF power divider split the signal with only . 3db losses below ideally split signal power. Perhaps most importantly however, all components accomplishing these specifications were low cost and within typical telemetry system power allocations of a 1U CubeSat, pulling less than 3.5W total. If implemented, this communication system design would be by far the most capable 1U CubeSat data link, and would be the first operating 1U CubeSat utilizing a phased array antenna. As such, the design allows for stronger signal reception at the ground station, pointing the beam directly where a low-cost CubeSat ADCS would fail to point the satellite and its antennas accurately.
Can the use of an inclinometer improve the positioning of the acetabular component in total hip arthroplasty?

Aims Accurate placement of the acetabular component is essential in total hip arthroplasty (THA). The purpose of this study was to determine if the ability to achieve inclination of the acetabular component within the ‘safe‐zone’ of 30° to 50° could be improved with the use of an inclinometer. Patients and Methods We reviewed 167 primary THAs performed by a single surgeon over a period of 14 months. Procedures were performed at two institutions: an inpatient hospital, where an inclinometer was used (inclinometer group); and an ambulatory centre, where an inclinometer was not used as it could not be adequately sterilized (control group). We excluded 47 patients with a body mass index (BMI) of > 40 kg/m2, age of > 68 years, or a surgical indication other than osteoarthritis whose treatment could not be undertaken in the ambulatory centre. There were thus 120 patients in the study, 68 in the inclinometer group and 52 in the control group. The inclination angles of the acetabular component were measured from de‐identified plain radiographs by two blinded investigators who were not involved in the surgery. The effect of the use of the inclinometer on the inclination angle was determined using multivariate regression analysis. Results The mean inclination angle for the THAs in the inclinometer group was 42.9° (95% confidence interval (CI) 41.7° to 44.0°; range 29.0° to 63.8°) and 46.5° (95% CI 45.2° to 47.7°; range 32.8° to 63.2°) in the control group (p < 0.001). Regression analysis identified a 9.1% difference in inclination due to the use of an inclinometer (p < 0.001), and THAs performed without the inclinometer were three times more likely to result in inclination angles of > 50° (odds ratio (OR) 2.8, p = 0.036). The correlation coefficient for the interobserver reliability of the measurement of the two investigators was 0.95 (95% CI 0.93 to 0.97). Conclusion The use of a simple inclinometer resulted in a significant reduction in the number of outliers compared with a freehand technique.
Written reflection in NHS appraisal: time for an alternative.

How did that go? How could I have done that better? We use reflection to help us process our feelings, and when something has gone wrong we try to understand why. The extension of this, reflection in medical practice, is a key part of our continuous learning and considered essential for professional competence. The General Medical Council (GMC) states that doctors ‘should regularly reflect on their own performance’ . 1 Reflection may be verbal (for example, through discussion with colleagues), internal (thinking about what we have done), or written (unstructured, for example, in a diary, or structured by use of a pro-forma). Most GPs do find reflection valuable, reporting that it is embedded into their daily routines —at work, on the way to and from work, and at home. Some feel that reflection can help with processing thoughts and feelings, describing it as ‘therapeutic’ and ‘cathartic’ in helping to process emotionally difficult situations. Reflective writing became an obligatory part of licensing and revalidation in the UK because it is thought to provide evidence of reflective thinking2 and show that doctors are continuing to learn. Reflections on learning activities are verified at a yearly appraisal, helping to provide the evidence for the 5-yearly revalidation that allows an individual to continue to work as a doctor.3 The Royal College of General Practitioners recommends that documentation of reflection on learning activities is necessary so that GPs can focus on the quality, rather than the quantity, of their appraisal supporting information,4 though it points out that documented reflection should be brief and to the point. …
Defects in NADPH Oxidase Genes NOX 1 and DUOX 2 in Very Early Onset In fl ammatory Bowel Disease 65 66 67 68

Q3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 All studies published in Cellular and Molecular Gastroenterology and Hepatology are embargoed until 3PM ET of the day they are published as corrected proofs on-line. Studies cannot be publicized as accepted manuscripts or uncorrected proofs.
Procedural and one-year outcomes of patients treated with orbital and rotational atherectomy with mechanistic insights from optical coherence tomography.

AIMS We sought to evaluate procedural complications and one-year clinical outcomes for patients who underwent percutaneous coronary intervention (PCI) with orbital (OA) and rotational atherectomy (RA). METHODS AND RESULTS From a total of 13,467 patients who underwent PCI in our hospital between January 2013 and June 2016, 1,149 consecutive patients were treated with atherectomy for moderately-severely calcified lesions (184 with OA, 965 with RA). Procedural complications were similarly observed in the two groups except for higher dissection and perforation rates with OA. Major adverse cardiovascular events (MACE) were defined as the composite of death, myocardial infarction or target lesion revascularisation. Multivariable adjusted analysis showed that OA use was associated with comparable adjusted one-year MACE compared to RA use (hazard ratio 0.79 [95% confidence interval 0.54-1.17], p=0.25). There were no significant differences in individual MACE endpoints. Furthermore, we studied 67 patients with OCT images. OCT analysis showed comparable tissue modification with a trend towards higher stent expansion with OA vs. RA. CONCLUSIONS OA use was associated with lower unadjusted but similar adjusted one-year MACE outcomes compared to RA with higher rates of dissection and device-induced perforation.
A Fine-Grained Data Access Control System in Wireless Sensor Network

The evolving realities of Wireless Sensor Network (WSN) deployed to various terrain of life require serving multiple applications. As large amount of sensed data are distributed and stored in individual sensors nodes, the illegal access to these sensitive data can be devastating. Consequently, data insecurity becomes a big concern. This study, therefore, proposes a fine-grained access control system which only requires the right set of users to access a particular data, based on their access privileges in the sensor networks. It is designed using Priccess Protocol with Access policy formulation adopting the principle of Bell Lapadula model as well as Attribute-Based Encryption (ABE) to control access to sensor data. The functionality of the proposed system is simulated using Netbeans. The performance analysis of the proposed system using execution time and size of the key show that the higher the key size, the harder it becomes for the attacker to hack the system. Additionally, the time taken for the proposed work is lesser which makes the work faster than the existing work. Consequently, a well secure interactive web-based application that could facilitates the field officers access to stored data in safe and secure manner is developed.
Models for predicting risk of dementia: a systematic review

Background Information from well-established dementia risk models can guide targeted intervention to prevent dementia, in addition to the main purpose of quantifying the probability of developing dementia in the future. Methods We conducted a systematic review of published studies on existing dementia risk models. The models were assessed by sensitivity, specificity and area under the curve (AUC) from receiver operating characteristic analysis. Results Of 8462 studies reviewed, 61 articles describing dementia risk models were identified, with the majority of the articles modelling late life risk (n=39), followed by those modelling prediction of mild cognitive impairment to Alzheimer’s disease (n=15), mid-life risk (n=4) and patients with diabetes (n=3). Age, sex, education, Mini Mental State Examination, the Consortium to Establish a Registry for Alzheimer’s Disease neuropsychological assessment battery, Alzheimer’s Disease Assessment Scale-cognitive subscale, body mass index, alcohol intake and genetic variables are the most common predictors included in the models. Most risk models had moderate-to-high predictive ability (AUC>0.70). The highest AUC value (0.932) was produced from a risk model developed for patients with mild cognitive impairment. Conclusion The predictive ability of existing dementia risk models is acceptable. Population-specific dementia risk models are necessary for populations and subpopulations with different characteristics.
Re(a)d Wedding: A Comparative Discourse Analysis of Fan Responses to Game of Thrones

It is no exaggeration to say that HBO’s Game of Thrones is more than just a television series or a successful brand: it is a transmedia system in the sense first used by Marsha Kinder (1991) and popularized by Henry Jenkins (2006), in which media-hopping networks of intertextualities extend the “storyworld” of an original production. Now spanning six seasons and 60 episodes, with an average global viewership (from its most recent season) of 25.1 million viewers per episode (Shepherd, 2016), it has spawned five video games, a graphic novel adaptation, several companion books, two rap albums, a 28-city orchestral tour, a wide variety of tabletop games, toys, merchandise and mobile apps, and countless podcasts, fanfics and other fan-based creations. Given the volume of content this represents, it is easy to forget that the television series itself is an adaptation of a book series with a pre-existing fandom. As such, the Game of Thrones storyworld represents a remarkably rich and challenging environment for fans old and new, who must negotiate an increasingly complex network of paratexts and intertexts in order to fully engage with its narratives. In this sense, fans of the series represent an emerging model for cultural consumption that should be carefully explored. Transmedia systems, like that exemplified by Game of Thrones, are becoming increasingly prevalent (e.g., Star Wars, Harry Potter, The Walking Dead, the Marvel Cinematic Universe, etc); these systems demonstrate, in microcosm, the global challenge of managing the fire-hose flow of information in contemporary postdigital society. The study of how people, as fans, access and manage information within a transmedia system provides valuable insight that contributes not only to practitioners and scholars of the media industry, but to the wider context of cultural studies, by offering findings on this new model of the fan as consumer and information-user. For us, as digital humanists, defining the “transmedia fan” is of particular relevance as we seek to understand contemporary social and cultural transformations engendered by digital technologies.
Genome Sequence of Staphylococcus aureus Ex1, Isolated from a Patient with Spinal Osteomyelitis

Here, we present the genome sequence of Staphylococcus aureus Ex1, isolated in 2015 from a patient with spinal osteomyelitis at the Royal Devon and Exeter Hospital in the United Kingdom. The availability of the Ex1 genome sequence provides a resource for studying the basis for spinal infection and horizontal gene transfer in S. aureus. ABSTRACT Here, we present the genome sequence of Staphylococcus aureus Ex1, isolated in 2015 from a patient with spinal osteomyelitis at the Royal Devon and Exeter Hospital in the United Kingdom. The availability of the Ex1 genome sequence provides a resource for studying the basis for spinal infection and horizontal gene transfer in S. aureus.
CircSNCA downregulation by pramipexole treatment mediates cell apoptosis and autophagy in Parkinson’s disease by targeting miR-7

We aimed to explore the mechanism of pramipexole (PPX) actions in the treatment of Parkinson’s disease (PD). Genes related to PD and PPX were screened through bioinformatics retrieval. The PD model was constructed by applying 1-methyl-4-phenylpyridinium (MMP+). The RNA expression levels of circSNCA, SNCA, apoptosis-related genes (BCL2, CASP3, BAX, PTEN and P53) and miR-7 were detected by qRT-PCR. Protein expression was determined by western blot. The interactions between circSNCA-miR-7-SNCA were verified by dual luciferase assay and immunofluorescence localization. Cell viability was determined by MTT assay. SNCA and circSNCA expression levels in PD were downregulated after PPX treatment, consistent with the levels of pro-apoptotic genes. CircSNCA increased SNCA expression by downregulating miR-7 in PD as a competitive endogenous RNA (ceRNA). Lower circSNCA expression was associated with the reduced expression of pro-apoptotic (CASP3, BAX, PTEN and P53) proteins. CircSNCA downregulation could decrease apoptosis and induce autophagy in PD. In conclusion, the downregulation of circSNCA by PPX treatment reduced cell apoptosis and promoted cell autophagy in PD via a mechanism that served as a miR-7 sponge to upregulate SNCA.
Analyzing the Patellar Tendon Force During Quadriceps Muscle Exercise

—The mechanics of the knee was analyzed in the sagittal plane to study the role of patellar tendon as influenced by the placement of external flexing loads on the tibia and by translation of the tibial bone 7mm anterior to the femoral bone during the flexion range 0–120 o. Anatomical parameters and measurements for orientations and moment arms of the patellar tendon during the flexion range were taken from experiments on cadaver knees available in the literature. The analysis suggests that the force in the patellar tendon varies directly with the distance of the external flexing load placed distal to the tibial surface. This effect is uniform throughout the joint flexion range. Further, 7mm anterior translation of the tibia relative to the femur resulted in significantly reduced anterior component of the net shear force for all flexion positions and all placements of loads distal to the joint line. This has relevance to ACL-deficient knees where large tibial translations may be necessary to compensate for the deficiency. Two critical factors that may require special attention to protect the ACL during rehabilitation exercises are the flexion angle and the position of the flexing load below the tibial surface.
Real and Imagined Geography at City-Scale: Sentiment Analysis of Chicago's "One Book" Program

Since fall 2001, the Chicago Public Library (CPL) has chosen fiction and nonfiction around which to organize city-wide public events, book discussions, and other creative programming. This “One Book One Chicago” (OBOC) program has been a successful ongoing civic initiative with great public visibility, with participants ranging from the Mayor of Chicago to countless book group volunteers across the city. Our “Reading Chicago Reading” project—supported by the National Endowment for the Humanities Office of Digital Humanities and Microsoft—works to discover how text characteristics, library branch demographics, and promotional activities are linked variables that can be used to predict patron response to future OBOC titles. The OBOC program acts as a recurring experiment in data capture, for each chosen work represents a probe into library usage and, by extension, a window onto the elective reading behavior of the diverse patrons of a major American city. This paper will report comparative circulation data for three recent OBOC choices that are Chicagocentered and three that are not Chicago-centered. The three Chicago-centered books are:
Endoscopic submucosal dissection with triangulated traction with clip and rubber band: the “wallet” strategy

Endoscopic submucosal dissection (ESD) is the reference method for the curative endoscopic resection of colorectal tumors [1, 2]. Nevertheless, it is technically challenging, and new strategies to facilitate the procedure are requested. Counter-traction strategies, such as the clip and rubber band approaches, allow the enlargement of the submucosal space [3, 4]. In the colon, line traction makes a tangential traction without triangulation, and is not really adaptive as the dissection progresses [5]. We report a case of ESD for a colonic laterally spreading tumor in a patient with a history of pancolonic ulcerative colitis. For this resection, we used the “wallet strategy” (▶Video1) in order to obtain a strong counter-traction to achieve en bloc resection in this fibrotic situation of ulcerative colitis. First, the two edges (oral and anal) of the lesion were incised. Then, trimming was performed at both edges in direct and retroflexed approaches, in order to achieve deep access to the submucosa and to release both mucosal edges (▶Fig. 1). After this step, two elastic rubber bands were fixed with hemoclips to both proximal and distal mucosal flaps. By trapping both rubber bands with a third metallic clip, we used triangulation traction and fixed the clip to the opposite mucosal wall (wallet aspect) (▶Fig. 2). The submucosa was fibrotic and fatty, which is typical in ulcerative colitis. Thanks to this double traction, the submucosa was strongly stretched perpendicularly to the muscular layer plan (▶Fig. 3d, ▶Fig. 4), facilitating dissection. This strategy must be compared prospectively with other traction strategies, but seems to offer a strong counter-traction with a perpendicular angle with the muscular layer. Stretching both proximal and distal edges allows the removal of the muscle from the cutting line and could improve safety. Furthermore, this strategy is adaptive, as the strength of Video 1 Colorectal endoscopic submucosal dissection with the “wallet” traction strategy.
Collaborations in the Global Midwest: The Diffusion of DH Values in Research Collaborations in the Humanities Without Walls consortium

The advent of new funding streams and initiatives within broader humanities scholarship indicate that the collaborative research approaches have diffused beyond digital humanities. This paper presents the findings of the “Humanities Collaboration and Research Practices: Exploring Scholarship in the Global Midwest” project (HCRP), which examines the Humanities Without Walls initiative as a case study for how innovative, interdisciplinary humanities research draws upon models from digital humanities.
Weighted Skin Color Segmentation and Detection Using Graph Cuts

In this work we propose a principal approach combining graph cuts, color weighting and texture information to segment skin regions from images. Successfully detected faces serve as foreground seeds, no assumptions about the background is made. Further, we introduce the concept of skin weights and skin weighted images. Performance is improved by efficiently adjusting pixel weights. Prior approaches do not provide a general skin detection when the information of foreground or background seeds is not available, e.g. when there are no faces present in the image. A concept for processing arbitrary images is introduced: We learn a universal seed to overcome the probable lack of successful seed detections. Experiments on a database of 300 images with annotated pixel-level ground truth show that the scheme outperforms widely used approaches. We also evaluate the effect of different edge detectors on graph cuts based skin segmentation. It is shown that a texture and color based weighting scheme improves skin segmentation compared to a color only weight-