Miracle-dz/UniFAR-FTUs huggingface dataset:
Title Identifying pelagic habitat hotspots of neon flying squid in thetemperate waters of the central North Pacific

We identified the pelagic habitat hotspots of the neon flying squid (Ommastrephes bartramii) in the central North Pacific from May to July and characterized the spatial patterns of squid aggregations in relation to oceanographic features such as mesoscale oceanic eddies and the Transition Zone Chlorophyll-a Front (TZCF). The data used for the habitat model construction and analyses were squid fishery information, remotely-sensed and numerical model-derived environmental data from May to July 1999–2010. Squid habitat hotspots were deduced from the monthly Maximum Entropy (MaxEnt) models and were identified as regions of persistent high suitable habitat across the 12-year period. The distribution of predicted squid habitat hotspots in central North Pacific revealed interesting spatial and temporal patterns likely linked with the presence and dynamics of oceanographic features in squid’s putative foraging grounds from late spring to summer. From May to June, the inferred patches of squid habitat hotspots developed within the Kuroshio-Oyashio transition zone (KOTZ; 37–40°N) and further expanded north towards the subarctic frontal zone (SAFZ; 40–44°N) in July. The squid habitat hotspots within the KOTZ and areas west of the dateline (160°W-180°) were likely influenced and associated with the highly dynamic and transient oceanic eddies and could possibly account for lower squid suitable habitat persistence obtained from these regions. However, predicted squid habitat hotspots located in regions east of the dateline (180°-160°W) from June to July, showed predominantly higher squid habitat persistence presumably due to their proximity to the mean position of the seasonally-shifting TZCF and consequent utilization of the highly productive waters of the SAFZ. PLOS ONE | DOI:10.1371/journal.pone. 0142885 November 16, 2015 1 / 20 a11111
STAT 2-dependent induction of RNA adenosine deaminase ADAR 1 by type I interferon differs between mouse and human cells in the requirement for STAT 1

Expression of adenosine deaminase acting on RNA1 (ADAR1) is driven by alternative promoters. Promoter PA, activated by interferon (IFN), produces transcripts that encode the inducible p150 ADAR1 protein, whereas PB specifies the constitutively expressed p110 protein. We show using Stat1 / , Stat2 / and IRF9 / MEFs that induction of ADAR1 p150 occurs by STAT2and IRF9-dependent signaling that is enhanced by, but not obligatorily dependent upon, STAT1. Chromatin immunoprecipitation analysis demonstrated STAT2 at the PA promoter in IFN-treated Stat1 / cells, whereas IFN-treated wild-type cells showed both STAT1 and STAT2 bound at PA. By contrast, with human 2fTGH cells and mutants U3A or U6A, ADAR1 induction by IFN was dependent upon both STAT1 and STAT2. These results suggest that transcriptional activation of Adar1 by IFN occurs in the absence of STAT1 by a non-canonical STAT2dependent pathway in mouse but not human cells. & 2015 Elsevier Inc. All rights reserved.
Patterns and variation in the mammal parasite–glucocorticoid relationship

Parasites are ubiquitous and can strongly affect their hosts through mechanisms such as behavioural changes, increased energetic costs and/or immunomodulation. When parasites are detrimental to their hosts, they should act as physiological stressors and elicit the release of glucocorticoids. Alternatively, previously elevated glucocorticoid levels could facilitate parasite infection due to neuroimmunomodulation. However, results are equivocal, with studies showing either positive, negative or no relationship between parasite infection and glucocorticoid levels. Since factors such as parasite type, infection severity or host age and sex can influence the parasite–glucocorticoid relationship, we review the main mechanisms driving this relationship. We then perform a phylogenetic meta‐analysis of 110 records from 65 studies in mammalian hosts from experimental and observational studies to quantify the general direction of this relationship and to identify ecological and methodological drivers of the observed variability. Our review produced equivocal results concerning the direction of the relationship, but there was stronger support for a positive relationship, although causality remained unclear. Mechanisms such as host manipulation for parasite survival, host response to infection, cumulative effects of multiple stressors, and neuro‐immunomodulatory effects of glucocorticoids could explain the positive relationship. Our meta‐analysis results revealed an overall positive relationship between glucocorticoids and parasitism among both experimental and observational studies. Because all experimental studies included were parasite manipulations, we conclude that parasites caused in general an increase in glucocorticoid levels. To obtain a better understanding of the directionality of this link, experimental manipulation of glucocorticoid levels is now required to assess the causal effects of high glucocorticoid levels on parasite infection. Neither parasite type, the method used to assess parasite infection nor phylogeny influenced the relationship, and there was no evidence for publication bias. Future studies should attempt to be as comprehensive as possible, including moderators potentially influencing the parasite–glucocorticoid relationship. We particularly emphasise the importance of testing hosts of a broad age range, concomitantly measuring sex hormone levels or at least reproductive status, and for observational studies, also considering food availability, host body condition and social stressors to obtain a better understanding of the parasite–glucocorticoid relationship.
BioSCOOP – Biobank Sample Communication Protocol. New approach for the transfer of information between biobanks

Abstract Dynamic development of biobanking industry (both business and science) resulted in an increased number of IT systems for samples and data management. The most difficult and complicated case for the biobanking community was cooperation between institutions, equipped with different IT systems, in the field of scientific research, mainly data interchange and information flow. Tools available on the market relate mainly to the biobank or collection level. Efficient and universal protocols including the detailed information about the donor and the sample are still very limited. Here, we have developed BioSCOOP, a communication protocol in the form of a well documented JSON API. The main aim of this study was to harmonize and standardize the rules of communication between biobanks on the level of information about the donor together with information about the sample. The purpose was to create a communication protocol for two applications: to transfer the information between different biobanks and to allow the searching and presentation of the sample and data sets.
Hypertension and diabetes mellitus as risk factors for asthma in Korean adults: the Sixth Korea National Health and Nutrition Examination Survey

Abstract Background Asthma is a chronic inflammatory disease that may associate with other chronic diseases such as hypertension and diabetes. We observed the effects of blood pressure (BP), fasting blood glucose (FBG), haemoglobin A1c (HbA1c) and insulin on asthma in Korean adults. Methods Data from 5045 adults were taken from the 2015 Sixth Korea National Health and Nutrition Examination Survey and analysed using a multiple logistic regression model. Results By age, the probability of asthma occurrence was 1.02 times higher (adjusted odds ratio [aOR] 1.02 [95% CI 1.01 to 1.03]). Specifically, asthma occurrence was increased in individuals >66 years of age (aOR 2.40 [95% CI 1.22 to 4.72]). The probability of asthma occurrence in females was higher than in males (aOR 1.73 [95% CI 1.02 to 2.84]). Hypertension and systolic blood pressure (SBP) were found to increase the probability of asthma occurrence by 1.43- and 1.03-fold, respectively. Diabetes mellitus (DM) was another factor that increased with the occurrence of asthma (aOR 1.75 [95% CI 1.06 to 3.02]). The probability of asthma occurrence was not increased with the FBG level, whereas HbA1c (aOR 1.38 [95% CI 1.03 to 1.84]) and insulin levels (aOR 1.02 [95% CI 1.01 to 1.04]) were shown to increase the occurrence of asthma. Conclusions Age, sex, hypertension, SBP, DM, HbA1c and insulin levels are all factors that may influence the occurrence of asthma in Korean adults. In particular, hypertension and diabetes emerge from the present study as potential associated factors for the development of asthma.
Emerging role of microRNA 628-5p as a novel biomarker for cancer and other diseases

MicroRNAs are a family of small, single-stranded RNAs that have key roles in regulating multiple signaling pathways within a cell. Studies have implicated aberrant expression of microRNAs in the development and progression of several pathologies including cancer. MicroRNAs are relatively stable and readily available in body fluids and tissues, making them desirable biomarkers for prognostic and diagnostic purposes in an array of diseases. MicroRNA 628 (5p/3p variants) is located in the 15q21.3 cancer-related region, and evidence suggests its association with various pathologies. The -5p mature variant, microRNA 628-5p, has been reported to be differentially expressed in various cancers, and its expression has been mostly associated with tumor suppression but there are few reports identifying its role in cancer progression. Several studies have also suggested its utility in diagnosis and prognosis of various cancers. Dysregulation of microRNA 628-5p has also been implicated in embryonal implantation defects, autism, immune modulation, myogenesis, cardiovascular disease, viral infection, and skeletal muscle repair. Here, we have provided a comprehensive review on available literature explaining the role of microRNA 628-5p as a potential cancer biomarker as well as briefly describe its function in other diseases and normal physiological conditions.
THE ACCOUNTANCY OF THE POTENTIAL INCOME LOST DUE PREMATURE DEATH : DIFFERENCES DETERMINED BY GENDER Valéria Gama Fully Bressan

In order to verify similarities and/or differenc es on the behavior of returns and volatility on traded stocks of Brazilian agribu siness companies, this study examines the existence of leverage effects and tests the hyp ot esis that trading volume is a useful proxy for information innovations, for a sample of 25 stock-listed Brazilian agribusiness companies. Using daily data from July/1999 to Janua ry/2007, two specifications of EGARCH models are tested, with and without trading volume as an explanatory variable. The results confirm the existence of leverage effec ts for almost all of the analyzed companies, and some influence of trading volume in the explanation of the volatility dynamics, but without any remarkable differences be twe n companies and/or their related sub-sectors.
GPseudoClust: deconvolution of shared pseudo-profiles at single-cell resolution

Motivation Many methods have been developed to cluster genes on the basis of their changes in mRNA expression over time, using bulk RNA-seq or microarray data. However, single-cell data may present a particular challenge for these algorithms, since the temporal ordering of cells is not directly observed. One way to address this is to first use pseudotime methods to order the cells, and then apply clustering techniques for time course data. However, pseudotime estimates are subject to high levels of uncertainty, and failing to account for this uncertainty is liable to lead to erroneous and/or over-confident gene clusters. Results The proposed method, GPseudoClust, is a novel approach that jointly infers pseudotem-poral ordering and gene clusters, and quantifies the uncertainty in both. GPseudoClust combines a recent method for pseudotime inference with nonparametric Bayesian clustering methods, efficient MCMC sampling, and novel subsampling strategies which aid computation. We consider a broad array of simulated and experimental datasets to demonstrate the effectiveness of GPseudoClust in a range of settings. Availability An implementation is available on GitHub: https://github.com/magStra/nonparametricSummaryPSM and https://github.com/magStra/GPseudoClust. Contact ms58@sanger.ac. uk Supplementary information Supplementary materials are available.
antimicrobial peptide from PD-L4, a type 1 ribosome inactivating protein of dioica A new of for

: Acca sellowiana is an evergreen plant, that produces edible fruit whit high nutritional properties, and also contains clinically relevant bioactive compounds, including polyphenols and essential oils. Numerous biological activities were demonstrated for A. sellowiana fruits: antifungal and antitumoral and anti-oxidant. It was also showed a strong antibacterial activity against Gram-positive and Gram-negative bacteria. Fruit are generally considered recalcitrant plant tissues for the difficulty to obtain high quality protein due to a low protein content and the presence of interfering substances. For this reason, the objective of the present work was obtain high quantity of protein extract, to determine the location in the fruit of the molecules responsible for the antibacterial activity, separate them according to molecular weight, test their thermo resistance, study the timing of action, isolate the protein fraction having activity and hypothesize a mechanism of action directed against bacterial membranes. total final Positive control cells
Kybernetes Governance for intelligent organizations : a cybernetic contribution

Purpose – This paper aims to revisit the viable system model (VSM) discussing it from both the theoretical and the empirical standpoints, and ascertaining its relevance for organizational governance. Design/methodology/approach – A combination of theoretical and empirical components is used: introduction to theory and critique on the one hand; case studies and a large sample empirical study on the other. Findings – The VSM has proved to be a powerful means of governance for organizations in turbulent times. It conveys a durable, reliable knowledge. This has been corroborated in both case studies and a large-scale empirical study. Practical implications – Application of the model under study can activate a huge potential for the improvement of organizations. Originality/value – This contribution tests the VSM in an unseen fashion – qualitatively and quantitatively. The results suggest that a high confidence in the model is justified. It conveys to managers and leaders an unconventional, superior approach to both diagnosis and design of their organizations.
MATURITY ASYMPTOTICS FOR A FAST MEAN-REVERTING HESTON STOCHASTIC VOLATILITY MODEL

In this paper, we study the Heston stochastic volatility model in the regime where the maturity is small but large compared to the mean-reversion time of the stochastic volatility factor. We derive a large deviation principal and compute the rate function by a precise study of the moment generating function and its asymptotic. We then obtain asymptotic prices for Out-of-The-Money call and put options, and their corresponding implied volatilities.
2018 Feature Map Feature Map OutputFeature Map Convonlution Convonlution Subsampling

High bandwidth requirements are an obstacle for accelerating the training and inference of deep neural networks. Most previous research focuses on reducing the size of kernel maps for inference. We analyze parameter sparsity of six popular convolutional neural networks AlexNet, MobileNet, ResNet-50, SqueezeNet, TinyNet, and VGG16. Of the networks considered, those using ReLU (AlexNet, SqueezeNet, VGG16) contain a high percentage of 0-valued parameters and can be statically pruned. Networks with Non-ReLU activation functions in some cases may not contain any 0-valued parameters (ResNet-50, TinyNet). We also investigate runtime feature map usage and find that input feature maps comprise the majority of bandwidth requirements when depth-wise convolution and point-wise convolutions used. We introduce dynamic runtime pruning of feature maps and show that 10% of dynamic feature map execution can be removed without loss of accuracy. We then extend dynamic pruning to allow for values within an epsilon of zero and show a further 5% reduction of feature map loading with a 1% loss of accuracy in top-1.
Also 10 Tribal Units : The Grouping of Cavalry on the Parthenon North Frieze TOSHIHIRO OSADA

This article proposes a new interpretation of the grouping of the horsemen on the north frieze of the Parthenon, based on close observation of the rendering of horses’ manes. The north and south sides of the frieze each depict 60 horsemen. Whereas the south frieze horsemen can be divided into 10 groups of six riders, the cavalry of the north frieze shows a more complicated composition, the grouping of which has been much debated. I argue here that the north frieze also illustrates 10 groups of six horsemen. The 10 groups of the south cavalry are distinguishable not only by their dress but also by the rendering of the horses’ manes. Although the northern riders wear utterly different clothes and could not be classified into any groups by their dress, the styles of the horses’ manes suggest that the cavalry on this side also consists of 10 groups. It is notable, too, that the 10 groups each include a “rank leader. ” Although the interpretation of the north frieze has often been related to the four archaic tribal divisions of Attica, it is now clear that both the north and south cavalries were intended to depict the 10 phylae of Periclean Athens. *
Synthesis of selenomethylene-locked nucleic acids (SeLNA) nucleoside unit bearing an adenine base

Abstract Synthesis of selenomethylene-locked nucleic acids nucleoside bearing an adenine base (SeLNA-A) was investigated. We first examined the stereoinversion reaction at 2′-positions of a 5′,3′-O-TIPDS-protected 4′-C-(hydroxymethyl)ribosyladenine derivative to give the corresponding arabinosyladenine. After triflation, treatment of the arabinosyladenine derivative with a mixture of selenium and sodium borohydride in ethanol managed to construct the desired SeLNA skeleton. Finally, removal of TIPDS by treating with fluoride gave the SeLNA-A nucleoside. In this study, we found the heat-labile property of SeLNA-A. It is necessary to know more precise characteristics of SeLNA to achieve its oligonucleotides synthesis.
REGIONAL AND SECTORAL EVIDENCE OF THE MACROECONOMIC EFFECTS OF LABOR REALLOCATION : A PANEL DATA ANALYSIS ?

This paper revisits the sectoral shifts hypothesis by examining unemployment fluctuations for 48 U.S. states over the period 1990:01–2011:12. We develop a panel approach that incorporates dynamics, parameter heterogeneity, aggregate factors and cross-sectional dependence. Our findings provide support for a positive and significant effect of the employment dispersion index on unemployment. This outcome is robust under alternative specifications and measures of employment dispersion. The empirical evidence corroborates the presence and relevance of cross-sectional dependence and heterogeneity among states. The results show that, once unobserved common factors and cross-state heterogeneity are taken into account, labor reallocation has a significant effect on unemployment that is half the size of the estimate when cross sectional dependence is not taken into account. (JEL E24 · E32 · J21 · R23 · C23) Acknowledgments: We would like to thank the Co-Editor and an anonymous referee for their constructive comments and helpful suggestions. We would also like to thank Karim Abadir, Richard Baillie, Ramazan Gençay, Jerzy Konieczny, Angelo Melino, Roberto Patuelli, Hashem Pesaran, Vasilis Sarafidis and Thanasis Stengos for their useful comments and suggestions on earlier versions of this work. Also we would like to thank Markus Eberhardt for kindly providing his STATA routines. Finally, we are grateful to the participants of the 2nd Time Series Workshop of the Rimini Center for Economic Analysis. All remaining errors are our own. Bakas: Nottingham Trent University, Nottingham Business School, Division of Economics, Burton Street, NG1 4BU, Nottingham, UK, E-mail: dimitrios.bakas@ntu.ac. uk Panagiotidis: University of Macedonia, Department of Economics, 156 Egnatia Street, 54006, Thessaloniki, Greece, E-mail: tpanag@uom.edu. gr (Corresponding Author) Pelloni: University of Bologna, Department of Economics, Via Anghera 22, 47900, Rimini, Italy, E-mail: gianluigi.pelloni@unibo.it
New Prospective for theManagement of Low-Risk Pulmonary Embolism : Prognostic Assessment , Early Discharge , and Single-Drug Therapy with NewOral Anticoagulants

Patients with pulmonary embolism (PE) can be strati�ed into two di�erent prognostic categories, based on the presence or absence of shock or sustained arterial hypotension. Some patients with normotensive PE have a low risk of early mortality, de�ned as <1% at 30 days or during hospital stay. In this paper, we will discuss the new prospective for the optimal management of lowrisk PE: prognostic assessment, early discharge, and single-drug therapy with new oral anticoagulants. Several parameters have been proposed and investigated to identify low-risk PE: clinical prediction rules, imaging tests, and laboratory markers of right ventricular dysfunction or injury. Moreover, outpatient management has been suggested for low-risk PE: it may lead to a decrease in unnecessary hospitalizations, acquired infections, death, and costs and to an improvement in health-related quality of life. Finally, the main characteristics of new oral anticoagulant drugs and the most recent published data on phase III trials on PE suggest that the single-drug therapy is a possible suitable option. Oral administration, predictable anticoagulant responses, and few drug-drug interactions of direct thrombin and factor Xa inhibitors may further simplify PE home therapy avoiding administration of lowmolecular-weight heparin.
Lawrence Berkeley National Laboratory Recent Work Title Co-Expression Network Analysis of Fbxw 7-Associated LncRNAs Reveals Their Functions in Radiation-Induced Thymic Lymphoma

FBXW7, an E3-ubiquitin protein ligase in SCFs (SKP1-cullin-F-box) complex, is a major human tumor suppressor gene, and understanding mechanisms by which FBXW7 contributes to tumorigenesis is critical for the treatment of human cancers with FBXW7 deficiency. Long noncoding RNAs (lncRNAs) have emerged as key regulators of various biological processes. Here we have identified a set of lncRNAs that are associated with Fbxw7 deficiency. The correlation network and functional annotation analysis revealed that Fbxw7-associated lncRNAs regulate genes involved in cell cycle, DNA repair, metabolic process, and cell communication and adhesion. The number of coding genes that correlated with individual lncRNAs varied largely. A lncRNA on chromosome 15 (A_30_P01032978), which was upregulated in tumors from Fbxw7 deficient mice was positively correlated with 15 coding genes. High expression of this 15-gene signature was associated with poor prognosis in two independent human breast cancer studies. Our results open possible new avenues to understand mechanisms by which Fbxw7 deficiency increases tumor susceptibility via the alteration of lncRNAs.
Numerjcal Simulation of Turbulent Spots in Channel and Boundary Layer Flows

The initiation and early growth of spots in channel and boundary layer flows is simulated using a three-dimensional spectral code. The simulated spots show significant agreement with available experimental data for such quantities as growth rates and spreading angles. Disturbances are introduced into the center and edge of the developing channel spots to investigate the relative sensitivity of spots.