Miracle-dz/UniFAR-FTUs huggingface dataset:
Bone marrow-derived mesenchymal stem cell composited with platelet rich plasma improved repair of annulus fibrosus rupture

Purpose: This study was aimed to evaluate the effects of bone marrow-derived mesenchymal stem cells (BMSCs) composited with platelet rich plasma (PRP) on annulus fibrosus rupture repair. Methods: BMSCs were isolated from Ximeng goats (6 months, weighting 23-25 kg) and identified by detecting the expressions of CD29, CD34 and CD44 via immunohistochemistry. Then the proliferation of BMSCs was assessed using cell counting and MTT assay after cultured in medium containing 0, 0.1%, 0.2% and 0.3% PRP for 2 d, 4 d, 6 d and 8 d, respectively. In addition, the damaged intervertebral disc annulus fibrosus rupture model was built up with control, model and PRP-BMSCs groups. H & E staining, Masson tricolor gelatin staining, AB-PAS staining, and immunohistochemistry for type II collagen were performed to assess the histological changes of annulus tissue in different groups at 3, 6 and 12 weeks after surgery. Results: BMSCs were successfully isolated and identified with positive CD29 and CD34, but negative CD44. Cell proliferations of BMSCs were significantly increased with the PRP proportion increasing (P < 0.05). Decreasing bone and cartilage cells, maturated trabecular bone, increasing collagen fibers, as well as unclear cell and tissue structures were found in model group as compared with control group. Pathological conditions were notably improved in PRP-BMSCs group than those in model group (P < 0.05). Meanwhile, type II collagen was significantly increased in PRP-BMSCs group (P < 0.05). Conclusion: A combination therapy of BMSCs and PRP could effectively repair the damaged annulus tissue in goat model.
News-Driven Business Cycles in Small Open Economies

The focus of this paper is on news-driven business cycles in small open economies. We make two significant contributions. First, we develop a small open economy model where the presence of financial frictions permits the replication of business cycle co-movements in response to news shocks. Second, we use VAR analysis to identify news shocks using data on four advanced small open economies. We find that expected shocks about the future Total Factor Productivity generate business cycle co-movements in output, hours, consumption and investment. We also find that news shocks are associated with countercyclical current account dynamics. Our findings are robust across a number of alternative identification schemes.
SOUTHERN JOURNAL OF AGRICULTURAL ECONOMICS DECEMBER 1990 ECONOMIC IMPACTS OF STATE PARKS ON STATE ECONOMIES IN THE SOUTH

The economic impacts of recreational visits to state parks on the economies of North Carolina, South Carolina, Georgia, and Tennessee were estimated using the U.S. Forest Service IMPLAN input-output modeling system. Recreational expenditure data associated with state parks were obtained from the Public Area Recreation Visitors Study (PARVS). Results suggest that recreational spending may stimulate a considerable amount of economic activity in the state economies studied. Hence, future research into the economic development potential of outdoor recreation seems warranted.
A Continuous-Time Agency Model of Optimal Contracting and Capital Structure

We explore the financing of a project when the agent can privately benefit by taking actions that reduce cash flows, and investors' only means of forcing repayment is the threat of termination. We introduce techniques to solve for the optimal contract (given the incentive constraints) in continuous time, and study the properties of the capital structure that implements the contract. The implementation involves a credit line, long-term debt and equity, as in a discrete-time model of DeMarzo and Fishman (2003). The continuous-time setting allows for a much cleaner characterization of the contract in terms of a differential equation, which we can then use to derive a number of new results. The optimal length of the credit line is determined by trade-off between the flexibility to run the project when it temporarily generates losses, and cost of delaying dividends until the credit line is paid off. Surprisingly, we find that the firm's total debt capacity is relatively insensitive to the project's volatility or the cost of liquidation. We derive explicitly how the optimal mix of long-term debt and credit varies with project characteristics. For example, the amount of long-term debt decreases with the project's volatility, the cost of liquidation, and the inefficiency of diversion. In some cases, the optimal long-term debt is negative; i.e., the firm holds a compensating cash balance while simultaneously borrowing (at a higher rate) through the credit line. We consider the implications of our model for security prices, and show that in many settings, the usual agency problems between debt and equity holders (asset substitution, strategic default) do not arise, and that optimal leverage declines with the firm's past profitability.
Dynamical sampling with additive random noise

Dynamical sampling deals with signals that evolve in time under the action of a linear operator. The purpose of the present paper is to analyze the performance of the basic dynamical sampling algorithms in the finite dimensional case and study the impact of additive noise. The algorithms are implemented and tested on synthetic and real data sets, and denoising techniques are integrated to mitigate the effect of the noise. We also develop theoretical and numerical results that validate the algorithm for recovering the driving operators, which are defined via a real symmetric convolution.
Oral Manisfestations in HIV Patients

The main characteristic of a patient with Acquired Immunodeficiency Syndrome (AIDS) is the ineffectiveness of the individual's immune system. The high degree of immunological weakness in which these patients are found has a high impact on their quality of life and can be seen clinically in the oral cavity. Because of this, the present study sought to evidence the most frequent oral manifestations of the AIDS disease. It has been demonstrated in this literature review that there is no specific oral manifestation of AIDS, but rather opportunistic lesions that are related to a deficient immune system. Such lesions may be of bacterial, viral, fungal origin, neoplastic processes and lesions of unknown etiology, as well as periodontal manifestations, which may be aggravated by the use of tobacco, alcohol, antidepressants and inadequate oral hygiene. It was also presented the ineffectiveness of saliva as a form of contagion and the importance of good oral hygiene for regression and control of some lesions. For this reason, it is important to note the importance of the dentist to correct the clinical diagnosis of such lesions so that it is possible to refer the patient to an infectologist in order to perform immunological tests that confirm their diagnosis and allow the correct follow-up and treatment . Only treatment with highly active antiretroviral therapy (HAART) does not provide full recovery of the epithelial cells of the oral cavity; therefore, the rapid initial implementation of antiretroviral therapy combined with constant patient visits to the dentist, for correct plaque control and adequate oral hygiene, avoids the appearance of certain lesions and helps in the regression of others.
Experimental investigation of aminoacetonitrile formation through the Strecker synthesis in astrophysical-like conditions: reactivity of methanimine (CH2NH), ammonia (NH3), and hydrogen cyanide (HCN)

Astronomy & Astrophysics Experimental investigation of aminoacetonitrile formation through the Strecker synthesis in astrophysical-like conditions: reactivity of methanimine (CH 2 NH), ammonia (NH 3), and hydrogen cyanide (HCN) ABSTRACT Context. Studing chemical reactivity in astrophysical environments is an important means for improving our understanding of the origin of the organic matter in molecular clouds, in protoplanetary disks, and possibly, as a final destination, in our solar system. Laboratory simulations of the reactivity of ice analogs provide important insight into the reactivity in these environments. Here, we use these experimental simulations to investigate the Strecker synthesis leading to the formation of aminoacetonitrile in astrophysical-like conditions. The aminoacetonitrile is an interesting compound because it was detected in SgrB2, hence could be a precursor of the smallest amino acid molecule, glycine, in astrophysical environments. Aims. We present the first experimental investigation of the formation of aminoacetonitrile NH 2 CH 2 CN from the thermal processing of ices including methanimine (CH 2 NH), ammonia (NH 3), and hydrogen cyanide (HCN) in interstellar-like conditions without VUV photons or particules. Methods. We use Fourier Transform InfraRed (FTIR) spectroscopy to monitor the ice evolution during its warming. Infrared spec-troscopy and mass spectroscopy are then used to identify the aminoacetonitrile formation. Results. We demonstrate that methanimine can react with − CN during the warming of ice analogs containing at 20 K methanimine, ammonia, and [NH + 4 − CN] salt. During the ice warming, this reaction leads to the formation of poly(methylene-imine) polymers. The polymer length depend on the initial ratio of mass contained in methanimine to that in the [NH + 4 − CN] salt. In a methanimine excess, long polymers are formed. As the methanimine is progressively diluted in the [NH + 4 − CN] salt, the polymer length decreases until the aminoacetonitrile formation at 135 K. Therefore, these results demonstrate that aminoacetonitrile can be formed through the second step of the Strecker synthesis in astrophysical-like conditions.
Travel Cost Methods for Estimating the Recreational Use Benefits of Artificial Marine Habitat

Abstract The growing popularity of marine recreational fishing has created considerable interest in artificial marine habitat development to maintain and enhance coastal fishery stocks. This paper provides a comparative evaluation of travel cost methods to estimate recreational use benefits for new habitat site planning. Theoretical concerns about price and quality effects of substitute sites, corner solutions in site choice, and econometric estimation are considered. Results from a case study indicate that benefit estimates are influenced by the way these concerns are addressed, but relatively simple single site models can provide defensible estimates. Practical limitations on data collection and model estimation are also considered.
MULTIDIMENSIONAL TRANSITIONAL DYNAMICS: A SIMPLE NUMERICAL PROCEDURE

We propose the relaxation algorithm as a simple and powerful method for determining the transition process in growth models numerically. This method has a number of important advantages: (1) It can easily deal with a wide range of dynamic systems including stiff differential equations and systems giving rise to a continuum of stationary equilibria. (2) The application of the procedure is fairly user-friendly. The only input required consists of the dynamic system. (3) The variant of the relaxation algorithm we propose exploits in a natural manner the infinite time horizon, which usually underlies optimal control problems in economics. As an illustrative application, we compute the transition process of the models of Jones [Jones, C.I. (1995) R&D-based models of economic growth. Journal of Political Economy 103 (3), 759–784] and Lucas [Lucas, R.E. , Jr. (1988) On the mechanics of economic development. Journal of Monetary Economics 22, 3–42].
Thumbs Up and Down: Sentiment Analysis of Medical Online Forums

In the current study, we apply multi-class and multi-label sentence classification to sentiment analysis of online medical forums. We aim to identify major health issues discussed in online social media and the types of sentiments those issues evoke. We use ontology of personal health information for Information Extraction and apply Machine Learning methods in automated recognition of the expressed sentiments.
Balancing employee needs, project requirements and organisational priorities in team deployment

The ‘people and performance’ model asserts that performance is a sum of employee ability, motivation and opportunity (AMO). Despite extensive evidence of this people–performance link within manufacturing and many service sectors, studies within the construction industry are limited. Thus, a recent research project set out to explore the team deployment strategies of a large construction company with the view of establishing how a balance could be achieved between organisational strategic priorities, operational project requirements and individual employee needs and preferences. The findings suggested that project priorities often took precedence over the delivery of the strategic intentions of the organisation in meeting employees’ individual needs. This approach is not sustainable in the long term because of the negative implications that such a policy had in relation to employee stress and staff turnover. It is suggested that a resourcing structure that takes into account the multiple facets of AMO may provide a more effective approach for balancing organisational strategic priorities, operational project requirements and individual employee needs and preferences more appropriately in the future.
HIV 1 infection and reproductive history: a retrospective study among pregnant women, Abidjan, Cote d Ivoire, 1995-1996

The aim of this paper is to determine the differences of fertility between HIV 1 infected and uninfected women in Abidjan, Cote d Ivoire, using data available in an observational study conducted in 1995 and 1996 in 2 antenatal care centres in the district of Yopougon, Abidjan, within an intervention programme to reduce mother to child HIV 1 transmission DITRAME project, ANRS 049 . Fertility indicators have been constructed from retrospective data on pregnancies and births, and univariate and multivariate analyses have been performed on these indicators and stratified by age groups to compare HIV 1 positive and HIV negative populations. The main outcome measures were the number of pregnancies, the number of miscarriages, the risk of miscarriage and the proportion of primigravida. Four thousand, three hundred and ninety six women agreed to HIV testing: 12.1 were found to be HIV 1 infected. HIV 1 positive women had significantly fewer pregnancies than HIV negatives in age groups 25-29 P =0.05 and 30-34 P =0.008 . The risk of having had at least one abortion or stillbirth was significantly higher for HIV 1 infected women than for HIV negatives OR=1.28, 95 CI: 1.02-1.60 , when controlling for social and demographic factors. This study suggests that HIV 1 infection has deleterious consequences on female fertility, with lower fertility rates and more frequent adverse pregnancy outcomes. Family planning and antenatal care services should consider antenatal HIV counselling and testing in women in areas of high HIV prevalence.
Biological Property of Recombinant Hemagglutinin-Neuraminidase Protein of Avian Paramyxovirus Type 6 Expressed by Recombinant Baculovirus

Hemagglutination inhibition (HI) test employing whole virus antigen is a prescribed serological test for serotyping, diagnosis and surveillance for avian paramyxoviruses (APMVs). For use as alternative to the virus antigen, hemagglutininneuraminidase (HN) protein gene of the wild duck isolate APMV-6/WB12-163FS of APMV serotype 6 (APMV-6) was amplified, cloned and expressed in Spodoptera frugiperda insect cells. The HN gene of 1,842 bps in length showed nucleotide and amino acid homology of 93.4% and 97.1%, respectively with that of APMV-6 prototype strain. Putative sialic acid binding motif and potential N-linked glycosylation sites were conserved. In Western blot analysis, the expressed protein had a molecular mass of 66 kDa and reacted specifically with antiserum to APMV-6. In addition, the recombinant HN protein showed biological properties such as hemagglutination (HA) and elution. The recombinant HN protein produced from infected cells showed high HA titers (approximately 2 13 HA unit/ml). The HA activity of the recombinant HN protein was inhibited by antisera to APMV-6. In cross HA inhibition test, the recombinant HN protein had the highest titers with antisera to homologous APMV serotype, although there was weak cross reaction with some of antisera to other APMV serotypes. Our results indicated that recombinant APMV-6 HN protein would have the potential as alternative to the APMV-6 antigen in HI assays.
Attitudes, Study Habits, and Academic Performance of Junior High School Students in Mathematics

Mathematics as a discipline is considered as one of the most difficult subjects among Filipino learners. This study was conducted in a public national high school in the Mandaue City Division, Cebu, Philippines. The respondents were the 177 Grade 9 students enrolled in mathematics. These respondents were selected using probability random sampling. They were asked to answer a standardized survey questionnaire to assess their attitudes and study habits. The tool is consists of three parts. Part 1 gathers the socio-demographic profile of the respondents. Part 2 assesses the attitudes of the respondents towards mathematics, while Part 3 was used to assess the study habits of the respondents. Furthermore, their academic performance in mathematics was measured based on their first quarter grade, which was retrieved from the Registrar’s Office. The study revealed that those respondents had positive attitudes towards mathematics in terms of its value while they had a neutral attitude when it comes to their self-confidence, enjoyment, and motivation in mathematics. Also, the study shows that there was a negligible positive correlation between the attitudes and academic performance of the respondents in terms of their self-confidence, enjoyment, and motivation while there was a weak positive correlation between the value of math and their academic performance in math. It was concluded that students’ attitudes and their study habits are significant factors that affect their performance in mathematics. The researchers strongly recommend the utilization of the enhancement plan in the teaching of mathematics to junior high school students.
Computer Simulation as a Tool for Analyzing and Optimizing Real-Life Processes

In some real-life situations, the analysis of complicated systems using standard analytical methods of operational research represents a particularly difficult endeavor, due to the system’s complicated structure or the impossibility of reaching a mathematical solution. In cases when we are not able to use the standard methods of operational research, we can use simulation modeling. Sometimes simulation modeling as a tool for supporting practical decision-making offers a possible solution for this problem. The aim of this paper is to characterize briefly the development of discrete-event simulation methodology over the past 50 years on the grounds of the evolution of various simulation programs, describe the essentials of the simulation program tool Simul8 and present, on the basis of a case study, how we can analyze and optimize complicated real-life systems.
Remittances, Exchange Rate Regimes and the Dutch Disease: A Panel Data Analysis

Using disaggregated sectorial data, this study shows that rising levels of remittances have spending effects that lead to real exchange rate appreciation and resource movement effects that favor the nontradable sector at the expense of tradable goods production. These characteristics are two aspects of the phenomenon known as Dutch disease. The results further indicate that these effects operate more strongly under fixed nominal exchange rate regimes.
Calibration of Structured Light Vision System using Multiple Vertical Planes

Structured light vision system has been widely used in 3D surface profiling. Usually, it is composed of a camera and a laser which projects a line on the target. Calibration is necessary to acquire 3D information using structured light stripe vision system. Conventional calibration algorithms have found the pose of the camera and the equation of the stripe plane of the laser under the same coordinate system of the camera. Therefore, the 3D reconstruction is only possible under the camera frame. In most cases, this is sufficient to fulfill given tasks. However, they require multiple images which are acquired under different poses for calibration. In this paper, we propose a calibration algorithm that could work by using just one shot. Also, proposed algorithm could give 3D reconstruction under both the camera and laser frame. This would be done by using newly designed calibration structure which has multiple vertical planes on the ground plane. The ability to have 3D reconstruction under both the camera and laser frame would give more flexibility for its applications. Also, proposed algorithm gives an improvement in the accuracy of 3D reconstruction.
Research and application of Radix Notoginseng

In Chinese traditional medicine, Radix Notoginseng, the dried root of Panax Notoginseng Burkill (Panax notoginseng (Burk.) F. H. Chen) (Arialiaceae), is a well-known traditional Chinese medicine. The active constituents include saponin, dencichine, flavonoid, and polysaccharide. In this paper, some information on basic research and application, and introduce to the ethnopharmacology, chemistry, pharmacological actions and clinical application of Radix Notoginseng. Pharmacologically, the major functions of are (1) Invigorates blood circulation and reduces stasis of blood, stimulates the menstrual flow and actives venationcollaterals, dilates blood vessels, ameliorates blood circulation, prevents conglomeration of haematoblast and increases the blood flux to the brain. (2) It is used to treat apoplexy, hemiplegy, sequela of cerebrovascular diseases, ophthalmopathy, block of the centre vein of the retina, Eye Anterior chamber hemorrhage. (3) An injection of Total saponins can dilate blood vessels, ameliorate microcirculation, reduce obstruction in blood vessel. It has a good effect on treating Heart disease from lung disorders and heart exhaustion. (4) It has good effect on treating all kinds of hemorrhage diseases, such as, emptysis, ophthalmorrhagia, bleeding (all kinds of bleeding in general). It is also good for treating blood in stool, uterine bleeding, and excessive menstruation. (5) It is used for curing coronary heart disease. After taking it, patients’ condition were notably improved, and their cardiogram showed that when they rested or did sports, their condition was getting better. (6) When it is used to cure high blood fat, the high content of cholesterin or the total blood serum fat in blood is notably lowered. (7) Brain infarction: it has good effect on treating apoplexy caused by cerebral veins stasis. (8) It is used in curing toxic hepatitis, and the content of SGTP is notably reduced. It is also Anti-liver fibrosis, and can prevent hepatitis complicated by digestive path bleeding. (9) It can be used to cure skull flesh wound external wound of head, chronic kidney function failure, scar proliferation after burn and parodontitis. Clinically, Radix Notoginseng is one of the most important components of famous Chinese recipe and possesses a wide variety of applications in clinical practice. The herb is officially listed in the Chinese Pharmacopoeia. The medicinal use of the herb in different from that of ginseng. It is used mainly as a hemostatic drug in the treatment of different types of bleeding. Radix notoginseng had been showed to have satisfactory therapeutic effect on coronary disease, hemopetysis, hemoturia, head injury and infiantial acute nephritis.
EXISTENCE OF MULTIPLE SOLUTIONS FOR QUASILINEAR ELLIPTIC EQUATIONS IN R

In this article, we establish the multiplicity of positive weak solution for the quasilinear elliptic equation −∆pu+ λ|u|p−2u = f(x)|u|s−2u+ h(x)|u|r−2u x ∈ R , u > 0 x ∈ R , u ∈W (R ) We show how the shape of the graph of f affects the number of positive solutions. Our results extend the corresponding results in [21].