Miracle-dz/UniFAR-FTUs huggingface dataset:
Numerical study on the mixing quality of an electroosmotic micromixer under periodic potential

Improvement of the mixing quality of low Reynolds number flows in micro-dimensional devices is essential. This paper investigates the optimization of the effective parameters and their effects on the mixing quality in a two-dimensional active micromixer. The micromixer mixes fluids with different concentrations entering into a microchannel from different inlets by means of four microelectrodes placed on the walls of a mixing chamber. A time-dependent electric field is applied, and the resulting electroosmotic force perturbs the parallel streamlines in the otherwise highly ordered laminar flow. The governing equations are numerically solved using the finite element-based COMSOL Multiphysics (Version 5.2a) software. The electroosmotic actuated active micromixer was numerically studied for various values of inlet velocity, phase lag, frequency, and voltage amplitude. Once the optimum values of the effective parameters are obtained for the original micromixer, they are applied to the micromixers having different obstacle shape inside the mixing chamber. The results showed that the mixing quality strongly depends on the inlet velocity of the fluids, the electrodes phase lag, the frequency, and the voltage amplitude. In addition, the mixing quality does not depend on obstacle shape when the optimum values of these parameters were used.
KRAS status and efficacy in the first-line treatment of patients with metastatic colorectal cancer (mCRC) treated with FOLFIRI with or without cetuximab: The CRYSTAL experience

2 Background: Efficacy analyses of the randomized phase III CRYSTAL trial have shown a significant improvement in progression-free survival (PFS), overall response, and curative surgery rate when adding cetuximab to FOLFIRI in the first-line treatment of mCRC. Furthermore, KRAS mutation status has recently been shown to relate to outcome in mCRC patients (pts) treated with cetuximab as a single agent or in combination with irinotecan. Efficacy analyses have been repeated to evaluate the influence of KRAS mutation status in first-line pts treated with FOLFIRI with or without cetuximab under controlled study conditions. Methods: Blocks from archived tumor material were available from 587 of 1198 of the total pt population. Isolation of genomic DNA was performed directly from slides (3×10 μm). Determination was done by qPCR-based KRAS mutation analysis of codons 12/13. The KRAS-evaluable pts (n=540) were analyzed statistically to evaluate treatment effect stratified by KRAS mutation status (wild-type [wt] or.
Short-term report on transurethral diode laser vaporization of the prostate at Ahmadu Bello University Teaching Hospital, Zaria-Nigeria

Background: Laser vaporization of the prostate is an evolving addition to the armamentarium for prostate surgery. This is despite the availability of cheaper treatment modalities such as open prostatectomy and transurethral resection of the prostate (TURP). However, diode laser vaporization in this regard has the advantages of a shorter learning curve and minimal complications. This paper was aimed at assessing the effectiveness of this mode of therapy and to share our initial experience with this procedure. Patients and Methods: This was a prospective study carried out over a period of 18 months. All men requiring surgery for bothersome prostatic obstruction with benign prostate size ≤100 g were included. Those with malignant prostatic obstruction irrespective of size were also included. The exclusion criteria were benign prostate of size >100 g, and indication for open prostatectomy/channelization or medical therapy. Clearance was obtained from the Health Research Ethics Committee of the institution and informed consent was obtained from all the patients. Each patient's demographics and pre-, intra-, and post-operative details were entered into a pro forma. Results were analyzed using descriptive statistics. Results: Eleven men were included in this study, aged 59-81 years with a mean of 67 years. 63.6% had benign prostatic hyperplasia (BPH) while the remaining 36.4% had carcinoma of the prostate. The mean prostate size was 88 g with a range of 54-182 g. Main symptoms were severe or bothersome lower urinary tract symptoms (LUTS). The mean operating time (lasing time) was 65 min. There were no intraoperative complications and none required blood transfusion. Most had irrigation for only 24 h, one didn't require irrigation while two others required irrigation for 48 h and 72 h, respectively. Out of all the patients, 90.9% had catheter removed at ≤48 h, while one had catheter removed on the fifth postoperative day. All except one were discharged at 72 h or less postoperatively. All the patients had satisfactory subjective outcome at a mean follow-up of 9 months with a range of 1 to 18 months. Conclusion: We found transurethral laser vaporization of the prostate to be effective and safe in the treatment of prostatic obstruction. However, a study involving larger number of patients and longer follow-up will establish its true place in the management of prostatic obstruction in our environment.
Hepatitis E Virus in Human: The Current Status in Europe

Background: An increasing number of human hepatitis E virus (HEV) infections have been described in the last decade in Europe. In this review, we described the serological data concerning the general population and particular group of patients (i.e immunocompromised patients, pig farmers in different European countries). HEV genotype distribution and anti-HEV therapies are described in the second part of the review. Results: HEV antibody prevalence ranged from 1.3% (blood donors in Italy) to 21.5% (blood donors in Serbia). Only one paper described a seroprevalence of 52% found in blood donors of Toulouse; in this study an assay WANTAI (Wantai Biological Pharmacy, PE2-assay; Beiying, China) with high sensitivity was used. A study carried out in the Netherlands showed that pig veterinarians had a higher anti-HEV IgG prevalence than non-pig veterinarians (11% vs 6%), confirming that pigs represent an important source of HEV infection. Genotypes 3c, 3e, 3f are the main genotypes diffused in Europe, however, sporadic cases of autochthonous genotype 4 have been described in several countries (Spain, France, and Italy). Several cases of fulminant hepatitis E, all related to genotype 3, have been described. Conclusion: The data reported in this review suggests that hepatitis E virus a wide spread infection, even in industrialized countries. The serum prevalence varies greatly, depending on the geographic areas considered and the population studied. Moreover, the seroprevalence may be due to the diagnostic assay used for the detection of antibodies.
How to read the trendless sequences: the “universal” set of quantitative parameters

In this paper it is demonstrated a new set of “universal” parameters that help to read quantitatively any trendless sequence (TLS). This method is applied for solving the problem of selection of the “pattern” noise from the tested one and for calibration of random fluctuations expressing some qualitative inputs in terms of these quantitative parameters. This set of quantitative parameters allows to compare the TLS(s) of different nature (acoustic, mechanical, electrochemical, vibrational and etc.) with each other. Using the proposed algorithm, we analysed the differences between software simulated and experimentally generated white noises. We do suppose that the proposed “universal” scheme free from uncontrollable errors can find a wide application in solution of many practical problems.
Does Informational Equivalence Preserve Strategic Behavior? Experimental Results on Trockel's Model of Selten's Chain Store Story

The purpose of this study is to experimentally test Trockel’s game, which is a modelling of the classical Chain Store Game (CSG), and determine whether one of the two theories of Equality and Deterrence may better account for the observed behavior. The CSG is an example of a simple game in extensive form where the actual behavior of well-informed players cannot be expected to agree with the clear results of game theoretical reasoning. To explain the disagreement between the theory and the expected behavior, Trockel’s game is proposed as an alternative modelling of the scenario. The existence of more than one equilibrium in Trockel’s game opens a door for reputation building. This study is the first attempt to experimentally test this alternative game with the same purpose. According to my data, there is some evidence in favor of both Equality and Deterrence Hypotheses. However, since the strategies compatible with the Equality Hypothesis are played more frequently, I observe some patterns which share the same intuition with the Deterrence Hypothesis.
The Economic Consequences of Audit Firms’ Quality Control System Deficiencies

This study seeks to determine the role of audit firms’ quality control (QC) system deficiencies, as measured by the Public Company Accounting Oversight Board (PCAOB) inspection program, on audit quality and profitability. Using a unique dataset of firm-wide QC deficiencies identified by the PCAOB during its inspections of audit firms, I find a negative association between QC deficiencies, mainly performance-related, and audit quality. Furthermore, audits conducted by larger audit firms with more organization-level deficiencies appear less profitable, evidenced by more hours worked on the engagements, leading to lower fees per hour. These results appear to be partly explained by deficiencies in the tone at the top (a proxy for culture) and the audit methodology. Further evidence suggests that lack of remediation of QC system deficiencies has a negative influence on audit quality.
DFT and NBO Studies of Stability, Electronic, and Structural Features of the 2-fluoroacetaldehyde Conformers

In this investigation, the stability of the keto-enol forms and conformers of 2-fluoroacetaldehyde was investigated by LC-wPBE, B3LYP and M06-2X functionals and 6-311++G(d,p) basis set. The total energy, the energies of frontier orbitals, HOMO-LUMO gaps and total dipole moment of these molecules were estimated. These calculations show that more stability of the keto form in compared to enol form. Calculations at the LC-wPBE/6-311++G(d,p) level of theory reveal the more stability of I-conformer in compared to other conformers. Natural bond orbital (NBO) analysis was applied for illustrating the negative hyperconjugative effect on the conformers. In the basis of NBO analysis, the LP (O2) *(C-H) and LP (O2) *(C-C) interactions were responsible of the negative hyperconjugation in the examined compounds. The interaction energy, off-diagonal elements, and total steric energy values of these interactions were reported.
Recourse-Cost Constrained Robust Optimization for Microgrid Dispatch With Correlated Uncertainties

To accomplish more practical scheduling of microgrids under source-load uncertainties, this article first proposes a novel recourse-cost constrained adaptive robust optimization (RC-ARO) model with binary recourse variables. The dispatch plan in the nominal scenario is optimized in the first-stage to get the minimal operation cost, then the adjustment plan in the worst scenario is determined in the second-stage that minimizes the recourse-cost. This model has overcome the defect of conventional adaptive robust optimization (ARO), which can only get the scheduling plans in the worst scenario. Second, a spatiotemporal correlation model of wind power uncertainty is further developed based on the similarities of power time sequences, aimed at avoiding impossible scenarios in reality and reducing the conservativeness of independent uncertainty sets. Third, a new column-and-constraint generation (C&CG) algorithm with alternating optimization procedure (AOP) is developed to directly obtain the binary solution, which helps accelerating the solution of RC-ARO model using traditional nested-C&CG. Finally, case studies demonstrate the effectiveness and superiority of the proposed RC-ARO model, the developed uncertainty sets, and the novel solving algorithm. The solving time of C&CG-AOP reduces by half compared with nested-C&CG, and a larger scale of decision variables under uncertainties brings more significant speedup by the proposed algorithm.
Network and multi-scale signal analysis for the integration of large omic datasets: applications in Populus trichocarpa

Poplar species are promising sources of cellulosic biomass for biofuels because of their fast growth rate, high cellulose content and moderate lignin content. There is an increasing movement on integrating multiple layers of ’omics data in a systems biology approach to understand gene-phenotype relationships and assist in plant breeding programs. This dissertation involves the use of network and signal processing techniques for the combined analysis of these various data types, for the goals of (1) increasing fundamental knowledge of P. trichocarpa and (2) facilitating the generation of hypotheses about target genes and phenotypes of interest. A data integration “Lines of Evidence” method is presented for the identification and prioritization of target genes involved in functions of interest. A new post-GWAS method, Pleiotropy Decomposition, is presented, which extracts pleiotropic relationships between genes and phenotypes from GWAS results, allowing for identification of genes with signatures favorable to genome editing. Continuous wavelet transform signal processing analysis is applied in the characterization of genome distributions of various features (including variant density, gene density, and methylation profiles) in order to identify chromosome structures such as the centromere. This resulted in the approximate centromere locations on all P. trichocarpa chromosomes, which had previously not been adequately reported in the scientific literature. Discrete wavelet transform signal processing followed by correlation analysis was applied to genomic features from various data types including transposable element density, methylation density, SNP density, gene density, centromere position and putative ancestral centromere position. Subsequent correlation analysis of the resulting wavelet coefficients identified scale-specific relationships between these genomic features, and provide insights into
Stuck at the Bar: Larger‐Than‐Average Grain Lag Deposits and the Spectrum of Particle Mobility

Larger‐than‐average grain deposits in gravel bed rivers potentially exert a distinctive influence upon fluvial morphodynamics and flow resistance. They are products of historical contingency, sourced from rare events that supply atypically coarse material. Larger‐than‐average grain lag deposits are emblematic attributes of the Tongariro River, New Zealand. They are deposited on bar edges and heads. Derived from lahar valley floor deposits that subsequently became terraces, these materials are less likely to be reworked across a range of flows compared to other bar material. Conceptual models that consider channel configuration and incorporate distributions of particle mobility and flood flows are necessary to assess the role of larger‐than‐average grain deposits on river morphodynamics.
The Perspective of Physical Education and Sport Teachers on the Participation of Parents of Students with Disability

Besides exploring the phenomenon of participation of parents of students with disability in special need schools, it is significant to gain the perspective of physical education and sport teachers because a teacher is the influential figure in the environment who interacts directly with students. In addition, students with disability are obliged to participate in physical education and sport lesson. Accordingly, it is fundamental to gain the perspective from physical education and sport teachers as the learning facilitator. For that reason, the objective of this preliminary research was to explore the meaning of the teacher that was constructed from parents’ participation in physical education and sport learning. Therefore, this research highlighted the understandings of: first, the notion of teachers in parents’ participation; second, the importance of teacher in physical education and sport learning process and their involvements in parents’ participation; third, teachers’ experiences in physical education and sport learning and the relation with parents of students with disability.
Surgical Management of Delayed Presentation of Osteochondral Knee Injuries in Adolescents - Case Series and Literature Review

Osteochondral fractures (OCF) are injuries to the articular surface of a joint containing both cartilaginous and bone components. The most common mechanisms are thought to be direct trauma secondary to patellar dislocation [1] or indirect shear forces caused by knee twisting, commonly resulting in lateral femoral condyle injuries [2] Due to generalised ligamentous laxity in adolescents, both patellar dislocation and shear stresses are more likely to occur, with a reported incidence of acute patellar dislocation of 107 per 100,000 in children between 9 and 16 years old [3]. Further increasing the vulnerability in this age group is the fact that the osteochondral junction in adolescents has reduced biomechanical strength when compared to the mature one [4]. Historically, undisplaced fractures were treated conservatively or fixed insitu. Acute displaced fractures were fixed primarily and neglected or missed injuries were considered as loose bodies and excised. Surgical treatments have been developed, and are based on either fixation, via several methods, or regenerative procedures such as microfracture, osteochondral transplantation (allograft or autograft) or autologous chondrocyte implantation. Procedures such as microfracture, osteochondral transplantation (allograft or autograft) and autologous chondrocyte implantation. The current literature is dominated by case studies and small case series reporting the use of different methods in the acute setting. The impact of time to fixation on results has been identified as an important question that has not been addressed [5]. This is a pertinent question due to challenging nature of diagnosis in these patients by plain radiographs [6], leading to a large proportion of late presentations. We describe the results of two cases of OCF with fixation by bioabsorbable osteochondral darts, following late presentation.
Quality Inference Based Task Assignment in Mobile Crowdsensing

With the increase of mobile devices, Mobile Crowdsensing (MCS) has become an efficient way to ubiquitously sense and collect environment data. Comparing to traditional sensor networks, MCS has a vital advantage that workers play an active role in collecting and sensing data. However, due to the openness of MCS, workers and sensors are of different qualities. Low quality sensors and workers may yield noisy data or even inaccurate data. Which gives the importance of inferring the quality of workers and sensors and seeking a valid task assignment with enough total qualities for MCS. To solve the problem, we adopt <italic>truth inference</italic> methods to iteratively infer the truth and qualities. Based on the quality inference, this paper proposes a task assignment problem called <italic>quality-bounded task assignment with redundancy constraint</italic> (QTAR). Different from traditional task assignment problem, redundancy constraint is added to satisfy the preliminaries of truth inference, which requires that each task should be assigned a certain or more amount of workers. We prove that QTAR is NP-complete and propose a <inline-formula><tex-math notation="LaTeX">$ (2+\epsilon)$</tex-math><alternatives><mml:math><mml:mrow><mml:mo>(</mml:mo><mml:mn>2</mml:mn><mml:mo>+</mml:mo><mml:mi>ε</mml:mi><mml:mo>)</mml:mo></mml:mrow></mml:math><inline-graphic xlink:href="gao-ieq1-2965932.gif"/></alternatives></inline-formula> - approximation algorithm for QTAR, called QTA. Finally, experiments are conducted on both synthesis data and real dataset. The results of the experiments prove the efficiency and effectiveness of our algorithms.
Monitoring the Environmental Temperature of the Arduino Assistance Engineering Faculty Using Telegram

The temperature of the air is the state of hot air caused by the heat of the sun. Factors that affect the amount of solar heat received by the earth are cloud, the surface plane, the angle of the sun, and the length of the sun's exposure. The heat of the earth's surface by solar radiation affects the heat of the air. Earth's surface air temperature varies because sunlight spreads unevenly on the earth's surface. The research aimed to design and implement a series of tools that can measure the ambient temperature and provide information about the environmental temperature via telegram. The methods used in this research were analyses consisting of needs analysis, and analysis of how it worked. Hardware and software implementations were also applied. The research carried out several tests, including tests on the DHT11 sensor, LED light, LCD i2c, Ethernet Shield, and Telegram test. The integration test on the LCD showed that when the temperature was below or the same as 25˚C, the green LED would be ON and the red LED OFF, which indicated that it was cold temperature. Conversely, when the temperature was the same or above 30˚C, the red LED would be ON, and the green LED OFF, indicating that the temperature was hot. The second test was to compare digital and analog sensors. The comparison values of the digital and analog temperatures were 1.1˚C, and the humidity was 23.1% RH. The highest temperature obtained from the system per day was 34˚C, and the lowest temperature was 23˚C.
COGNITIVE SIMULATION OF PRICE CHANGES AND MONEY COSTS OF THE POPULATION OF THE REPUBLIC OF KAZAKHSTAN.

The problem is solved in the article: for a given real multidimensional sample of values m = 44 values of 6 x-factors and m = 44 values of the “dial-up traffic” indicator, find generalized factors of very low purchasing power of the population of the Republic of Kazakhstan. 3 generalized factors containing change indicators are found prices and cash expenses of the population of the Republic of Kazakhstan and 2 measurable indicators “the need to buy (save money, build) a house (apartment)” (urgent need, 20,98%) and the strongly expressed “need for the Internet” (civilized income of an individual, 25.745). The dynamics of these factors and indicators reduced the purchasing power of the population.