Miracle-dz/UniFAR-FTUs huggingface dataset:
Research and Design of Atrial Fibrillation Early Warning Service System Based on Mobile Internet

Atrial fibrillation is closely related to hypertension. In view of the few studies on the combination of atrial fibrillation and blood pressure, an atrial fibrillation sphygmomanometer which can measure both atrial fibrillation and blood pressure simultaneously is developed. Meanwhile, a cloud platform for atrial fibrillation early warning service and a discriminant model for atrial fibrillation are built. Supported by mobile Internet, Internet of Things and cloud computing, with atrial fibrillation and hypertension as the research object, an atrial fibrillation model was established by mixing circulating neural network (RNN) and short-term memory network (LSTM). Then we applied the model to MIT-BIH Atrial Fibrillation Database and results verified that the accuracy is as high as 98.9%. Finally, to make the system more comprehensive, we developed patient-side and physician-side APPs, including atrial fibrillation recognition, physician teleservice and health care recommendations, and doctors monitor patient synopsis in real time and provide personalized medical services.
Comparative plasma proteomics in muscle atrophy during cancer‐cachexia and disuse: The search for atrokines

Skeletal muscle atrophy is common across a variety of pathologies. Underlying mechanisms of atrophy differ between pathologies, and in many conditions, circulating factors are tied to muscle atrophy. Therefore, we sought to identify alterations to the plasma proteome across divergent forms of muscle atrophy, disuse and cancer cachexia, as potential mediators of atrophy. C57BL6/J mice were assigned to Lewis Lung Carcinoma (LLC)‐induced cachexia, disuse by hindlimb unloading (HU), or control (CON). Plasma samples were submitted for discovery proteomics and targets of interest confirmed by immunoblot. Considerably more peptides were altered in plasma from LLC (91) than HU (9) as compared to CON. Five total proteins were similarly modulated in HU and LLC compared to CON, none reached criteria for differential expression. Serum Amyloid A1 (SAA) was 4 and 6 Log2FC greater in LLC than CON or HU, respectively, confirmed by immunoblot. Recent reports suggest SAA is sufficient to induce atrophy via TLR. Therefore, we assessed TLR2,4, and IL‐6 mRNAs in hindlimb muscles. TLR mRNAs were not altered, suggesting SAA effects on atrophy during LLC are independent of TLR signaling. However, we noted > 6‐fold induction of IL‐6 in soleus of HU mice, despite minimal shift in the plasma proteome, indicating potential localized inflammation in atrophying muscle. Furthermore, paraoxonase 1 (PON1) was highly repressed in LLC mice and largely undetectable by immunoblot in this group. Our data suggest SAA and PON1 as potential novel atrokines for cancer cachexia and indicate localized inflammation in atrophying muscles independent of the plasma proteome.
Expression of Monocarboxylate Transporter 1 in Immunosuppressive Macrophages Is Associated With the Poor Prognosis in Breast Cancer

Monocarboxylate transporter 1 (MCT1) participates in the transport of lactate to facilitate metabolic reprogramming during tumor progression. Tumor-associated macrophages (TAMs) are also involved in the inflammatory adaptation of the tumor microenvironment (TME). This study aimed to determine the correlation between metabolite changes and the polarization of macrophages in the TME. We demonstrated that the expression of CD163 on macrophages was significantly higher in breast cancer tissues than in normal tissues, especially in the HER2 subtype, although it was not statistically associated with recurrence-free survival (RFS). The presence of MCT1+ and CD163+ macrophages in the invasive margin was significantly correlated with decreased RFS. A significant correlation existed between MCT1 and CD163 expression in the margin, and high infiltration of MCT1+CD163+ macrophages into the margin predicted rapid progression and poor survival outcomes for breast cancer patients. These data suggested that MCT1 at least partially promoted the alternative polarization of macrophages to inhibit antitumor immunity, and blocking this interaction may be a promising method for breast cancer therapy.
C1q Regulates Horizontal Cell Neurite Confinement in the Outer Retina

During development, neurons generate excess processes which are then eliminated in concert with circuit maturation. C1q is the initiating protein in the complement cascade and has been implicated in this process, but whether C1q-mediated elimination is targeted to particular neural compartments is unclear. Using the murine retina, we identify C1q as a specific regulator of horizontal cell neurite confinement. Subsets of horizontal cell dendritic and axonal neurites extend into the outer retina suggesting that complement achieves both cellular and subcellular selectivity. These alterations emerge as outer retina synapses become mature. C1q expression is restricted to retina microglia, and the loss of C1q results in decreased microglia activation. This pathway appears independent of the C3a receptor (C3aR) and complement receptor 3 (CR3), as horizontal cells are normal when either protein is absent. Together, these data identify a new role for C1q in cell and neurite-specific confinement and implicate microglia-mediated phagocytosis in this process.
"Spermnests" in the oviduct of the domestic hen

Quinlan, Mari? ½ and Roux [1932 (a) and (b), 1933] found that spermatozoa after coitus in sheep, survived considerably longer in the cervix uteri than in any other part of the genital tract. They state that under favourable conditions the cervix acts as a reservoir from which there is a constant issue of active sperm cells to the cranial division of the tract. This finding, which agrees with the observations of Giles (1919) in women, recalls examples of long periods of survival of spermatozoa in lower animals. In the queen bee, for instance, the spermathecum may contain functionally normal sperm cells for seven years after coitus (Bishop, 1920), and many invertebrates have similar spermatheca.
Ursodeoxycholic Acid Protects Against Arsenic Induced Hepatotoxicity by the Nrf2 Signaling Pathway

Arsenic is ubiquitous toxic metalloid responsible for many human diseases all over the world. Contrastingly, Ursodeoxycholic acid (UDCA) has been suggested as efficient antioxidant in various liver diseases. However, there are no reports of the effects of UDCA on arsenious acid [As(III)]-induced hepatotoxicity. The objective of this study is to elucidate the protective actions of UDCA on As(III)-induced hepatotoxicity and explore its controlling role in biomolecular mechanisms in vivo and in vitro. The remarkable liver damage induced by As(III) was ameliorated by treatment with UDCA, as reflected by reduced histopathological changes of liver and elevation of serum AST, ALT levels. UDCA play a critical role in stabilization of cellular membrane potential, inhibition of apoptosis and LDH leakage in LO2 cells. Meanwhile, the activities of SOD, CAT and GSH-Px and the level of TSH, GSH were enhanced with UDCA administration, while the accumulations of intracellular ROS, MDA and rate of GSSG/GSH were decreased in vivo and in vitro. Further study disclosed that UDCA significantly inhibited As(III)-induced apoptosis through increasing the expression of Bcl-2 and decreasing the expression of Bax, p53, Cyt C, Cleaved caspase-3 and 9. Moreover, UDCA promoted the expression of nuclear Nrf2, HO-1, and NQO1, although arsenic regulated nuclear translocation of Nrf2 positively. When Nrf2 was silenced, the protective effect of UDCA was abolished. Collectively, the results of this study showed that UDCA protects hepatocytes antagonize As(III)-induced cytotoxicity, and its mechanism may be related to activation of Nrf2 signaling.
Reproductive Ecology of Tibetan Partridge Perdix hodgsoniae in Lhasa Mountains, Tibet

Data on the breeding ecology of Tibetan Partridges (Perdix hodgsoniae) were collected in shrub environments near Lhasa, Tibet, during 1999-2001. Partridge flocks broke up in mid-March and individuals typically formed socially monogamous pair bonds. During daily activities the both members of the pair were close to each other, with 73.5% of observed individual distances less than 2m. The egg-laying period extended from late May to late June. Average egg size was 16.1 (±SE=0.2) g in mass and 39.2 (±0.1)×28.1(±0.1) mm in dimension. Average clutch size was 8.3 (±0.8, range 5-12) The partridge produced larger eggs and smaller clutches than its two congener species, Grey Partridge (P. perdix) and Daurian Partridge (P. dauuricae). Incubation lasted about 23 days, and 44.4% of clutches successfully hatched. Vegetation characteristics were the most important determinants of partridge nest-site choice, with patches of low, sparse, and secondary cover being preferred. Nest-sites were also significantly closer to paths than random sites.
Precise Orbit Determination of the China Seismo-Electromagnetic Satellite (CSES) Using Onboard GPS and BDS Observations

The Global Navigation Satellite System (GNSS) occultation receiver onboard the China Seismo-Electromagnetic Satellite (CSES) can provide dual-frequency observations for both GPS and BDS-2 satellites. In this study, the data quality and orbit determination performance of the CSES are assessed. Severe data loss of about 30% is observed in GPS P2/L2 data, resulting in only 11% of epochs possessing six to eight useful GPS satellites. Due to fewer channels being allocated for BDS signals, less than 5% of epochs have more than three useful BDS satellites. Precise orbit determination (POD) of CSES is firstly carried out using GPS data. The results indicate that the orbit overlap differences improved from 3.65 cm to 2.8 cm in 3D root mean square (RMS) by antenna phase center correction. CSES orbits are then derived from the BDS only, and combined GPS and BDS data. BDS-based POD indicates that adding BDS geostationary Earth orbit (GEO) satellites could dramatically degrade the orbit accuracy. When excluding BDS GEO satellites, the orbit overlap differences of BDS-based and combined POD are 23.68 cm and 2.73 cm in 3D, respectively, while the differences compared with GPS-based POD are 14.83 cm and 1.05 cm, respectively. The results suggest that the obtained orbit can satisfy centimeter-level requirements. Given that large GPS tracking losses occurred and few channels are allocated for BDS signals, it is expected that POD performance can be further improved by increasing the number of dual-frequency observations.
DEMONSTRATION OF THE ELEMENTAL DISTRIBUTION IN BIOLOGICAL TISSUES BY MEANS OF THE ELECTRON MICROSCOPE AND ELECTRON PROBE X-RAY MICROANALYZER

There are very important functional significances in the cell-physiology, if one could observe the distribution of organizing elements of cells overlapping the cellular ultrastructures. Since Komnick 1962 (6), many investigaters have tried to demonstrate the localization of ions in the tissues (6, 7, 8, 9, 10, 16, 17, 19, 20, 21), such as sodium, chloride, calcium, or potassium in the electron microscopic level. They applied the inorganic qualitative methods for the electron microscopic observations, as shown in the Table 1 (13,16) . In such methods, the descrimination of the reaction-products is the most important problem. For instance, potassium antimonate which is a reagent for the detection of sodium-ion makes electron opaque fine precipitate with sodium (Fig. 1), as well as with calcium, magnesium and zink. No body can identify which precipitate corresponds to the sodium antiomonate, or calcium antimonate, in the electron micrograph (12). In the case of chloride-ion detection in the tissue,
Characterization of potato (Solanum tuberosum L.) adquirido de Centro Internacional de la Papa.

In vitro Plantlets formation potentiality of potato was investigated to establish a disease free plantlet system in potato. The study was carried out in In-vitro Preservation Lab, Plant Genetic Resource Institute (PGRI), National agriculture Research Centre (NARC) Islamabad, from January to February 2014. The germplasm of exotic potato is routinely maintained in In Vitro laboratory on MS media. Aim of the study was to investigate the effects of hormone on In Vitro virus free plantlet of potato. MS medium supplemented with 3 mg/L of BAP showed (5.79 cm) shoots fine performance in respect of multiple shoot regeneration in 6.5 days and (8.5) in MS+1mg/L BAP. Shoot length (4.0 cm) was observed in MS + 3mg/L BAP. Simple MS medium formed lowest number of shoot (2.14) per plant. MS + 6% sucrose + 3 mg/BAP combination of treatment show (20) shoots with length (6.5cm) in (25.5) days for in vitro virus free plantlets.
Review of biological processes in oil sands: a feasible solution for tailings water treatment

The bitumen extraction process from Athabasca oil sands ore produces large quantities of toxic processed water as tailings. The oil industry has reduced the demand for fresh water in the extraction process by recycling this tailings water. Continual recycling increases the toxicity of tailings water many times over, and poses a serious threat to surface and groundwater quality. For a sustainable expansion of Canada’s oil sands industry, it is essential to develop a technically practicable and economically feasible tailings water treatment technology. A review was carried out to describe the integral role of biological processes in oil sands history for identifying a successor tailings water treatment technology. This study proposes the application of an entrapped cells system as a feasible solution for tailings water treatment. Bio-augmentation followed by entrapment of the microbial community indigenous to tailings ponds can be a promising tailings water treatment technology.
Specific Limits and Distribution of Meadowlarks of the Desert Grassland

THE polytypic Eastern Meadowlark (Sturnella magna) has a breeding range that extends throughout eastern North America westward to Ontario, Nebraska, Texas, and Arizona, and southward through Central and South America as far as northern Brazil. A monotypic sibling species, the Western Meadowlark (Sturnella neglecta), breeds only in western North America eastward to the Great Lakes region, Missouri, and Texas, and southward on the Mexican plateau to northern Jalisco. A poorly differentiated northwestern race, S. neglecta confluenta, is currently recognized by the A.O. U. Check-list (1957). The breeding ranges of these species overlap broadly throughout the north-central United States, from Oklahoma northeastward into Ontario. Their behavioral and ecological interrelationships within this zone of sympatry have been described elsewhere (Lanyon, 1953, 1956, 1957). A similar analysis of their sympatric relationship in the southwestern United States and in Mexico has been delayed because of the (1) considerable confusion that exists even among contemporary ornithologists as to the specific identification of the meadowlarks breeding in these regions and, owing to this confusion, (2) a lack of reliable distributional data for these areas. The Mexican Check-list states, for example, that the southern limits of the breeding ranges of S. neglecta and S. magna lilianae are not known (Miller et al., 1957). The objectives of this paper are (1) to present the specific limits for those populations of the two species that are involved in the area of geographical overlap in the southwestern United States and Mexico, and (2) to summarize the distributional data for this area based on a reexamination of the material currently available. A preliminary discussion of their ecological relationships in this zone is included. A map of the breeding ranges of the populations under consideration here is presented in Figure 1. On the basis of evidence reviewed during this study, the current taxonomic treatment of the breeding populations within the area of geographical overlap in the southwestern United States and in Mexico appears adequate (Miller et al., 1957), with two races of magna and the monotypic neglecta involved. The breeding ranges of the three races appear to be as follows (cf. Figure 1): (1) Sturnella magna lilianae Oberholser breeds from north-central Arizona east to central eastern New Mexico and south to northern Sonora, Chihuahua, and the Big Bend region of Texas; (2) S. magna auropectoralis Saunders breeds from Sinaloa and central Durango southward, intergrading with S. m. alticola south of the area of sympatry;
Flat friction stir spot welding of AZ31B magnesium alloy using double side adjustable tools: microstructure and mechanical properties

A flat friction stir spot welding (FSSW) using double side adjustable tools has been developed to join magnesium alloy plates, through which sound joints bearing high mechanical performance and good surface appearance without keyhole have been successfully obtained. In this flat FSSW method, failure behaviour can only happen in the plate thickness direction due to the significantly enlarged bonded width. Sound joints can be obtained at low rotation speed; consequently, the average grain size in the tip area of the unbonded interface can be significantly decreased and the corresponding texture becomes random, giving rise to superior joint properties.
A Study of Interest and Capital

THE aim of this paper is to study the determinatioon and interdependence of the rates of interest yielded by different kinds of securities. The complexity of the subject makes it necessary to divide it into three parts. In Part I we make an attempt to determine the price and rate of output of securities in a general way; and as securities are a commodity of which large stocks are always extant, we shall begin with a short discussion on the general theory of supply and demand of commodities of which large stocks are usually held, and so derive the price of securities in analogy with ordinary supply and demand analysis. It will be seen that in this way we arrive at a theory of interest rates which is fundamentally a generalisation of Mr. Keynes' liquidity preference theory for any number of securities. In Part II we shall analyse the several criteria according to which securities differ from each other. This will lead us to a more complete understanding of the interdependence of different rates of interest and to a new explanation of the relative movements of longand short-term rates. In Part III we shall restate the theory in a slightly different form and compare it with the " real " theory of interest and capital. It is possible to conceive of the rate of interest as being determined by the supply and demand either of capital goods, or of securities, or of money. In this paper we shall always think of it as being determined in the market for securities, and to make the analogy with the supply and demand analysis of consumers' commodities easier, we shall have to think in terms of security prices as well as in terms of yields. This may be a little inconvenient at first because of the inverse relationship between the price and yield of a security, but I hope that the advantages of this approacl
Comprehensive quantification of fuel use by the failing and nonfailing human heart

Metabolomics, at the heart With heart failure a leading cause of death, a better understanding of metabolic function in the heart is a welcome advance. Murashige et al. measured more than 270 metabolites using liquid chromatography–mass spectrometry in human blood samples taken from an artery entering the heart and from a vein leaving it. Differences thus reflected the metabolic processes at work in the heart. Their results confirmed that hearts voraciously consume fatty acids. Hearts secreted, rather than consumed, amino acids, thus revealing active proteolysis. In patients with heart failure, ketone and lactate consumption increased, as did proteolysis. These findings could lead to strategies for fighting heart disease by altering metabolism. Science, this issue p. 364 Metabolomics shows what it takes to keep the heart pumping. The heart consumes circulating nutrients to fuel lifelong contraction, but a comprehensive mapping of human cardiac fuel use is lacking. We used metabolomics on blood from artery, coronary sinus, and femoral vein in 110 patients with or without heart failure to quantify the uptake and release of 277 metabolites, including all major nutrients, by the human heart and leg. The heart primarily consumed fatty acids and, unexpectedly, little glucose; secreted glutamine and other nitrogen-rich amino acids, indicating active protein breakdown, at a rate ~10 times that of the leg; and released intermediates of the tricarboxylic acid cycle, balancing anaplerosis from amino acid breakdown. Both heart and leg consumed ketones, glutamate, and acetate in direct proportionality to circulating levels, indicating that availability is a key driver for consumption of these substrates. The failing heart consumed more ketones and lactate and had higher rates of proteolysis. These data provide a comprehensive and quantitative picture of human cardiac fuel use.
Experimental and multiscale quantum mechanics modeling of the mechanical properties of PVC/graphene nanocomposite

In current work, we developed mechanical properties of PVC (polyvinyl chloride)/graphene nanocomposite theoretically and experimentally. In our theoretical model, a multi-scale finite element model was used to predict Young’s modulus of the stated nanocomposite. The molecular structure of pristine graphene was treated using the density functional theory (DFT) method. By assuming graphene as a space-frame structure that preserves the discrete nature of graphene, they were modeled by the use of three-dimensional elastic beam elements for the Carbon-Carbon covalent bonds and point mass elements for the atoms. Then interfacial van der Waals interaction that exists between PVC and graphene was modeled using the general form of Lennard–Jones potential and simulated by a nonlinear truss rod model. The Lennard–Jones parameters and van der Waals forces were determined versus separation distance for the stated nonlinear truss rod via the DFT method. Finally, we prepared PVC/graphene samples with different weight percentages of graphene nanoplatelets experimentally using the melt-mixing procedure. Our computational modeling demonstrated that the magnitudes of Young’s modulus PVC/graphene were close to the experimentally obtained results until 1 wt% with an average difference of about 25%. Finally, we justified the obtained mechanical results by investigating the morphology of experimental samples using Transmission electron microscopy (TEM) and Scanning Electron Microscopy (SEM) images.
Draft Genome Sequences of Two Virulent Streptococcus equi subsp. zooepidemicus Swine Isolates from Pennsylvania

Draft genome sequences of two outbreak isolates of Streptococcus equi subsp. zooepidemicus from one of the Pennsylvania swine herds affected with high mortality and morbidity are reported here. The genome analysis revealed that the isolates are closely related to a virulent strain originally identified in China. ABSTRACT Draft genome sequences of two outbreak isolates of Streptococcus equi subsp. zooepidemicus from a Pennsylvania swine herd affected with high mortality and morbidity are reported here. The genome analysis revealed that the isolates are closely related to a virulent strain originally identified in China.