Miracle-dz/UniFAR-FTUs huggingface dataset:
VSEPRnet: Physical structure encoding of sequence-based biomolecules for functionality prediction: Case study with peptides

Predicting structure-dependent functionalities of biomolecules is crucial for accelerating a wide variety of applications in drug-screening, biosensing, disease-diagnosis, and therapy. Although the commonly used structural “fingerprints” work for biomolecules in traditional informatics implementations, they remain impractical in a wide range of machine learning approaches where the model is restricted to make data-driven decisions. Although peptides, proteins, and oligonucleotides have sequence-related propensities, representing them as sequences of letters, e.g., in bioinformatics studies, causes a loss of most of their structure-related functionalities. Biomolecules lacking sequence, such as polysaccharides, lipids, and their peptide conjugates, cannot be screened with models using the letter-based fingerprints. Here we introduce a new fingerprint derived from valence shell electron pair repulsion structures for small peptides that enables construction of structural feature-maps for a given biomolecule, regardless of the sequence or conformation. The feature-map introduced here uses a simple encoding derived from the molecular graph - atoms, bonds, distances, bond angles, etc., that make up each of the amino acids in the sequence, allowing a Residual Neural network model to take greater advantage of information in molecular structure. We make use of the short peptides binding to Major-Histocompatibility-Class-I protein alleles that are encoded in terms of their extended structures to predict allele-specific binding-affinities of test-peptides. Predictions are consistent, without appreciable loss in accuracy between models for different length sequences, marking an improvement over the current models. Biological processes are heterogeneous interactions, which justifies encoding all biomolecules universally in terms of structures and relating them to their functionality. The capabilities facilitated by the model expands the paradigm in establishing structure-function correlations among small molecules, short and longer sequences including large biomolecules, and genetic conjugates that may include polypeptides, polynucleotides, RNAs, lipids, peptidoglycans, peptido-lipids, and other biomolecules that could be implemented in a wide range of medical and nanobiotechnological applications in the future.
Human action capturing and classification

Recognizing humans and activities in video is a key enabling technology for ultra-intelligent environments. These environments, which we call sentient spaces, are envisioned to be fully capable of sensing the motives and desires of occupants, and proactively reacting to them in ways to dramatically improve work productivity and quality of life. In this report, a vision-based framework is proposed for learning and inferring occupant activities at different levels. These levels range from short temporal interval movements, to intermediate level events and long temporal term activities. Our research is focused on using a combined tracking-classification framework for the unsupervised classification of human action. An initial comparative study was done to evaluate several existing foreground segmentation methods that employ background modeling. Our own probabilistic foreground-background segmentation method is proposed to extract human-centric reference frames. Based on the human-centric reference frames, a principled analysis of the correspondence problem leads to a novel probabilistic action representation called the correspondence-ambiguous feature histogram array (CAFHA) that is robust to variations across similar actions. CAFHA is shown to be effective in unsupervised action classification and quasi real-time action inference. A novel feature selection method is proposed to select the optimal features to improve the CAFHA representation, such that the best discrimination between different action clusters may be found via unsupervised spectral clustering. Finally, a number of potential future directions are proposed that are targeted at further improvements to our framework and creating new research methods required to recognize human activity at longer temporal scales. i ATTENTION: The Singapore Copyright Act applies to the use of this document. Nanyang Technological University Library
Restructuring the Social Web

The term Social Web is often used to describe a wide range of websites. So much so, that the term has become meaningless to many. This research shows what makes a website social and which functionalities these websites can be expected to offer to users. This is achieved by formulating a definition of the Social Web, a categorization of the different websites that are part of it and an analysis of the functionalities, plug-ins and API’s provided by ten websites that have been shown to be representative of the Social Web. We furthermore use this analysis to improve data ownership and data interoperability on the Social Web through the use of a distributed data storage method and an ontology capable of representing all information that is commonly found on the Social Web. Following that, a design is made in which these two improvements are incorporated, showing that a Social Web using these improvements is technically feasible and interesting for use in practice.
Scheme to JavaScript compilation

Cette these presente un compilateur de Scheme vers JavaScript. Bien que tres proches, ces deux langages different dans des points majeurs. En particulier, les continuations et la recursivite terminale, qui n'existent que dans Scheme, sont importantes dans le contexte d'une telle compilation. Dans ces travaux nous montrons que, sans ces deux fonctionnalites, produit du code aussi efficace que du code ecrit a la main. Cependant, ce langage reduit n'est pas conforme a R5RS, la specification de Scheme, mais represente un sous-langage pragmatique. Dans cette configuration est utilise quotidiennement dans notre projet. Bien que desactive par defaut, permet aussi la recursivite terminale et les continuations. Nous presentons dans cette these une implementation de la recursivite terminale qui se base sur la technique des trampolines. Elle a la propriete interessante de faciliter la coexistence d'un code genere et d'un code JavaScript existant. Notre implementation des continuations est une amelioration des continuation a base d'exceptions. Nous avons adapte des techniques developpees pour des continuations 'one-shot' (utilisees par exemple pour la migration). Pour capturer l'essence de notre algorithme de compilation des continuations nous avons developpe, une version canonique de notre implementation. Independant des fonctionnalites non-standard de Scheme, comme les exceptions, nous proposons comme alternative a CPS. Pour une version simplifiee de Scheme nous avons prouve que est correct.
Chronic fatigue syndrome and susceptibility to upper respiratory tract illness

Objectives. First, to determine whether chronic fatigue syndrome (CFS) patients report increased susceptibility to upper respiratory tract illnesses (URTIs) compared with healthy volunteers. Second, to determine whether symptom severity and use of medication is greater in CFS patients. Finally, to assess the impact of the URTIs on the subsequent clinical state of the patients. Design. A 10-week diary study. Methods. The frequency and severity of URTIs were recorded over a 10-week period by CFS patients (N = 62) and healthy controls (N = 44). The patients were selected according to the Oxford criteria and had previously been assessed at the Cardiff Chronic Fatigue Clinic. One group of patients and controls carried out the diary study from October to December, and another group from January to March. At the end of each of the 10-week periods the volunteers completed standard questionnaires about the frequency and severity of symptoms of colds and influenza and their general clinical condition. Results. CFS patients reported more cold and influenza illnesses than the controls. The patients also reported greater symptom severity and use of medication for the URTIs; these differences were still observed when trait anxiety was covaried. There was little evidence of the URTIs leading to longer term changes in the primary symptoms of CFS. Conclusions. CFS patients report more URTIs, greater symptom severity and greater use of medication for these illnesses than healthy controls. Further studies are now necessary to determine whether these results reflect greater susceptibility to infection or differences in symptom reporting. The present findings also suggest that acute infections do not play a major role in the pathogenesis of CFS.
Color Image Segmentation Based on Pyramid Link Approach

A new approach to color image automatic segmentation was presented based on pyramid linking approach.According to the independence of hue,saturation and brightness in HSV color space,color image was transformed from RGB model to HSV model.Then hue,saturation and brightness were segmented separately.Their results were combined as a final result.Experiments showed that this approach was automatic and efficient.
Highly-matched sub-ADC cells for pipeline analogue-to-digital converters

ABSTRACT The conventional single-stage comparators, as the basic elements of analogue-to-digital converters (ADCs), are modified for offset and mismatch errors to be utilised in multi-bit per stage pipeline structures. At first, in single-stage comparators, pre-amplification and latch operations are managed by temporary domination of positive or negative feedback via the bulk potential variations in PMOS (p-channel metal oxide semiconductor) devices. Then, the offset correction scheme is added to provide highly matched unit cells within the sub-ADCs of the pipeline structure. Monte-Carlo analysis with 100 iterations shows that input-referred offset reduces to 0.35 mV at σ, while input offset was randomly applied from a Gaussian distribution with 30 mV at 3σ. Using as unit cells of sub-ADCs in a 12-bit 100 MS/s pipeline ADC, ENOB (and SFDR) would be improved from 8.5-bits (and 53.6 dB) to 11.25-bits (and 74.2 dB), when offset error and bulk potential of PMOS devices experiences random variations with 25 mV and 60 mV at 3σ, respectively. Power consumption reaches to 0.45 mW at 625MS/s comparison speed. Post-Layout simulation results are presented at all process corners using the BSIM3v3 model of a 0.18 µm CMOS technology.
The putative transcription factor Prdm8 is required for the differentiation and maintenance of rod and cone bipolar cells in the mammalian retina.

Highly conserved genes that are abundantly and specifically expressed in the retina are likely to be important for retinal physiology or development. Prdm8 is expressed abundantly in retina and belongs to the PRDM (PR domain containing) protein family, conserved transcription factors important in the regulation of development and cancer. To begin to understand the role of Prdm8 in the retina, I cloned the cDNA and characterized Prdm8 expression in the mouse. Prdm8 encodes a PR domain and three zinc finger domains and is expressed predominantly in the developing and mature nervous system, including the retina, hippocampus and cerebellum. In the developing retina, Prdm8 mRNA is enriched in differentiating neurons. Together, these findings suggested that Prdm8 might be important for both neural development and maintenance. To determine whether Prdm8 is necessary for neural development, I generated Prdm8 null mice. Prdm8 mice are born at expected Mendelian ratios and viable, but have a hypocellular retina, develop prominent ventral skin lesions and display defects in hindlimb coordination, impaired spatial learning and memory, and changes in the volume of brain substructures.
The evaluation and comparison of thermo-physical, chemical and biological properties of palladium (II) complexes on binuclear diamine ligands with different anions using the DFT method

As cancer is the top killer diseases in the world, the scientists and researchers have been searching the new drugs and remedy methods. Most of the anticancer drugs are organic compounds which were approved by the FDA while metallodrugs are very rare. In the present time, some palladium and rhodium complexes are going to use as anticancer molecules. The palladium (II) complex has higher anticancer activity against different cancer cell that is why the different amine ligands are considered under theoretical study by the method of density functional theory (DFT) to make a new molecule. Some thermo-physical parameter was conducted such as free energy, entropy, dipole moment, binding energy, nuclear energy, electronics energy, the heat of formation. On the other hand, the chemical reactivity properties like occupied Molecular Orbital Highest (HOMO), Lowest Unoccupied Molecular Orbital (LUMO), HOMO-LUMO gap, ionization potential, electronegativity, hardness, softness and electron affinity, and biological properties like charge density, surface area grid, volume, LogP, polarizability, refractivity, molecular mass were calculated using the DFT method. To make comparative biological properties, different anions such as chloride, nitrate, hydroxide, carbonate and sulfate ions were used as homogeneous and heterogeneous adding.
The Value of Enhanced T1 High Resolution Isotropic Volume Examination (eTHRIVE) on Evaluation of Collateral Vessels in Esophageal Gastric Varices

Objective To investigate the value of enhanced T1 High Resolution Isotropic Volume Examination(e THRIVE) on evaluation of collateral vessels in esophageal gastric varices.Methods The eTHRIVE data of 82 cases with esophageal varices confirmed by the clinical history and relevant laboratory tests were analyzed retrospectively,the position,extent of esophageal varices,the characteristics of collateral blood supply and shunt vessels in esophageal varices were observed.The results were consistency analyzed with the endoscopy using Kappa test.Results 78 of 82 cases were diagnosed as esophageal gastric varices with eTHRIVE inspection,there were 27 cases with esophageal varices and gastric varices.There were 19 cases with simple gastric varices.There were 32 cases with simple esophageal varices.59 esophageal varices were supplied by left gastric vein.11 of 19 simple gastric varices were supplied by lefr gastric vein.5 of 19 simple gastric varices were supplied by left gastric vein,short gastric veins and posterior gastric veins.3 of 19 were supplied by short gastric vein / posterior gastric vein.10 cases with splenorenal shunt.2 cases with left gastric vein and left renal vein shunt.Compared with gastroscopy,esophageal varices had well correlation with eTHRIVE inspection(Kappa = 0.845);gastric varices had an ordinary correlation with eTHRIVE inspection(Kappa = 0.721). Conclusion eTHRIVE inspection is able to show the esophageal varices and gastric varices;meanwhile it is able to show characteristics of blood supply,which has great significance in choosing clinical treatment plans
Middle Range Theories: Application to Nursing Research and Practice

The most complete and detailed book devoted to middle range theories, Middle Range Theories: Application to Nursing Research and Practice examines theories and their applications in clinical nursing research and practice. In this fourth edition, the authors address this dynamic relationship with increased emphasis on applications of middle range theories to practice. Every theory chapter includes examples of the theory's use in research, its application to clinical practice and critical thinking exercises. The authors provide expert advice on selecting the appropriate theory for a nursing research project and developing the critical thinking skills needed to critique theories. Each theory chapter provides the nurse researcher with a variety of tools. Key features of the fourth edition include: *Brand New chapters exploring concepts surrounding Spiritual Care and Change*Definitions of key terms to define concepts and aid the reader's understanding of theories*New research studies, diagrams, and explanations to illustrate "The Arc"-how theory improves practice and practice shapes theory*Research Application boxes provide a sample application of the theory modeling the research process*Critical Thinking Exercises at the end of each chapter engage readers in analysis of the theory and its application to practice*Examples of Theory in Practice tables link research to evidence-based practice
Cyborg-Computer Interaction: Designing New Senses

: Cyborgs are among us. Integrating technology with the human body is not science fiction anymore as people started to apply various devices into their body to increase their abilities and senses. Although ethical debates on improving human abilities continue, technological developments have made devices that enhance human capacity small and accessible. Previous studies discussed cybernetic organisms (cyborgs) from an anthropological, sociological, bioethical and technical perspective. Although the interaction between cyborgs and the computers that are extensions of their bodies is crucial, there are few discussions on how to design new abilities and senses in cyborgs. Before describing a design guideline for cyborgs, we need to understand the concept of the cyborg, its characteristics and design potential. This study examines the previous definitions of cyborg to explore the potential to design the augmented human and proposes three parameters to define a design framework.
Utilization of Coconut Fiber as a Poor Households Empowerment Base (A Case in Bongomeme District of Gorontalo Regency, Indonesia)

Poor households have not utilized coconut fiber that is very potential to improve their welfare. This study analyzed the root causes of poor households not yet utilizing the potential of coconut fiber craft as a source of livelihood. The potential of crafts that can be developed from coconut fiber and the strategy of building institutional, commercial business groups of poor households are based on the manufacture of coconut fiber crafts to be competitive and sustainable. The researchers collected data through observation, in-depth interviews, focused group discussion, and literature review. The results show that lack of knowledge is at the root of the leading cause of poor households not utilizing coconut fiber as their livelihood. The other causes are lack of skills, low education, weak access to information, lack of collective awareness, and a false understanding that coconut fiber handicraft products are not sold in the market. Even though the facts show that if processed into handicraft products, coconut fiber can be used by poor households to improve their welfare so that they can be economically empowered. Various strategies can be carried out to build the institutional economic business groups of poor households based on the manufacture of coconut fiber crafts, namely critical awareness, strengthening the capacity of poor households, both through skills training, on the job training, and in-service training. Besides, comparative studies of entrepreneurship can also be carried out, opening up access to information, opening access to micro-business financing, and building networks of poor households to the outside world.
Geriatric and physiatric oriented rehabilitation after hip frac- ture temporarily improves the ability to live independently. A randomised comparison of 538 patients

Backround and purpose: Our objective was to examine the effects of three differ ent rehabilitation settings on the clinical outcome following surgical treatment for hip fracture. Methods: 538 consecutive, independently living patients with non-pathological hip fracture were randomised to physiatrically oriented rehabilitation (187 patients, mean age 77.5 years, PORG), geriatrically oriented rehabilitation (171 patients, mean age 79.1 years, GORG), and to routine rehabilitation in health centre hospitals (180 patients, mean age 77.7 years, Control Group = CG). The groups were evaluated 4 and 12 months after admission for age, sex, social status, associated diseases, physical and mental condition on admission, residential status, walking ability, use of walking aids, pain in the hip, activities of daily living (ADL), re-operation rate, hospital stay and mortality. Results: At 4 months more patients of the PORG and GORG were able to live at home or sheltered housing than those of the CG ( P=0.0012 and P<0.001, respectively) but the difference between PORG and GORG was not significant ( P=0.278). Separate analysis of cervical and trochanteric fractures showed that the significant difference was true only for cervical fractures (PORG vs GORG P=0.308, PORG vs CG P<0,001 and GORG vs CG P<0.001). The effects of intensified rehabilitations had disappeared at 12 months. No significant impact on walking ability or ADL functions was observed. Mortality was significantly lower at 4 and 12 months in the PORG than in the GORG (P=0.026, P=0.005, respectively) or CG (P=0.006, P=0.004, respectively). Interpretation: We found that both rehabilitation modalities significantly increased especially among the cervical fracture patients the number of patients able to live independently within a short follow-up (4 months) and thus reduced the need for institutional care as compared with routine after-treatment, however this effect was transient. Physiatric rehabilitation also seemed to reduce mortality.
Optimisation Algorithm for 60-GHz Non-Contact Human Vital-Sign-Monitoring

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Optimisation Algorithm for 60-GHz Non-Contact Human Vital-Sign-Monitoring Ting Zhang, Julien Sarrazin, Guido Valerio, Dan Istrate
Ventriloquie, performativité et communication

Cet article introduit la notion de ventriloquie, concue metaphoriquement comme le processus par lequel des interlocuteurs animent ou font parler des figures (le nom que les ventriloques utilisent pour parler des mannequins qu’ils manipulent), des figures qui sont elles-memes censees animer ces memes interlocuteurs en situation d’interaction. Ventriloquiser des figures (par exemple, des valeurs, des principes, des regles, des faits etc.), c’est se mettre a parler en leur nom et ainsi gagner en autorite en donnant du poids a son propos. Des phenomenes de pouvoir peuvent ainsi etre identifies dans l’interaction sans qu’il faille s’eloigner d’une approche performative et interactionniste du social.
Enhancing the Internet of Things Architecture with Flow Semantics

In academia reference architectures in software engineering and other engineering disciplines are used to help bring clarity to a complex problem. It is the intent that reference models inform practice and help deliver superior solutions. As practitioners know in engineering, particularly in software engineering, what is designed on paper too often falls short of what is required for the customer in the real world. This state of affairs provides us with two opportunities, first we can take existing, successful commercial implementations of a complex system and see where the literature may fall short or differ in structure. Likewise, we can look at the reference architectures and see if they can inform practice of their shortcomings or illuminate a path for future development in real world systems. In this paper we evaluated a commercial IoT (‘Internet of Things’) platform that was developed organically over a period of several years with the Internet of Things Architectural Reference Model developed by IoT-A. The intent is for practice and literature to inform each other on best practices and expand our knowledge of IoT platform design and architecture.