Miracle-dz/UniFAR-FTUs huggingface dataset:
TACG_A_344107 467..472

1Department of Biology and Genetics, Vietnam Military Medical University, Hanoi, 12108, Vietnam; 2Director Office, Hai Phong Hospital of Obstetrics and Gynecology, Haiphong, 40000, Vietnam; 3Obstetrics and Gynecology Department, Haiphong University of Medicine and Pharmacy, Haiphong, 40000, Vietnam; 4Département de formation Biologie moléculaire et cellulaire, Sorbonne University, Paris, 75006, France; 5Military Institute of Clinical Embryology and Histology, Vietnam Military Medical University, Hanoi, 12108, Vietnam; 6Faculty of Biology, VNU University of Science, Vietnam National University, Hanoi, 12108, Vietnam
On asymptotical & numerical analyses of liquid jets

Liquid jet breakup is a commonly occurring phenomenon in the world and controlling the breakup process is very important and useful in many industrial, engineering and medical fields. In this thesis, we investigate the behaviour of liquid jets and, in particular, how to control the breakup of liquid jets. For that purpose, we examine the behaviour of linear and nonlinear waves travelling along a liquid jet using two different methods, the classical method and then the Needham-Leach method. We perform a linear temporal instability analysis of steady-state solutions and obtain a temporal dispersion relation, which we solve numerically to investigate the behaviour of maximum growth rates and maximum wave numbers of the most unstable wave disturbance. We also obtain the nonlinear temporal equations, which we solve to get useful information about the breakup length, main and satellite drop sizes, by changing key physical parameters of the problem. We obtain useful information about the liquid jet breakup, the region of breakup and, most importantly, the means of controlling the liquid jet breakup. We also obtain an asymptotic solution to the liquid jet equations for large space and time limits.
Sporadic and familial non-syndromic congenital cataracts: novel variants, extended phenotypes and new diagnoses using next-generation sequencing

Non-syndromic congenital cataract is a genetically heterogeneous condition with over 30 known disease genes. It has a significant impact on visual acuity and can be associated with other ocular abnormalities such as microcornea, microphthalmia, anterior segment dysgenesis and glaucoma. Some patients may have an unrecognized syndromal diagnosis. In this study, 46 probands with congenital cataracts were recruited, around half were familial and half were sporadic. Targeted next-generation sequencing with analysis of cataract-associated genes identified pathogenic variants in over 70% of our patients, with similar mutation detection rates in familial and sporadic cases. Over 75% of the likely causative variants were novel. In almost two-thirds (20/33) of the cases where causative variants were identified, this resulted in new information about the inheritance pattern for the family. This included sporadic cases found to be due to de novo autosomal dominant or X-linked mutations. In addition, an apparently autosomal dominant family was found to be due to mutations in two separate cataract genes in the one family. Variants were found in the crystallin and gap junction genes, as well as more rarely reported genes including PAX6 , MAF , VIM, MIP, and BFSP1. Mutations in X-linked syndromal genes BCOR and NHS were found in 4 families, providing valuable genetic information for these families. Severe anterior segment abnormality and microphthalmia in addition to cataract, was found in a patient with a novel GJA8 mutation, emphasizing the need for inclusion of this gene in consideration for patients with these extended phenotypic features. highlights the benefits of an NGS approach with analysis of a targeted group of genes in the genetically heterogeneous condition of non-syndromic congenital cataracts. We achieved a mutation detection rate of in 46 families Approximately half the cases and similar detection in the and Previous studies have shown in using
Diazoxide Restores b 3 -Adrenergic Receptor Function in Diet-Induced Obesity and Diabetes

We previously demonstrated that the expression and function of the adipocyte-specific b 3 -adrenergic receptor ( b 3 AR) are significantly depressed in single gene and diet-induced rodent models of obesity. Furthermore, these models are relatively unresponsive to the anti- obesity effects of b 3 AR agonists. Because all of these models are hyperinsulinemic, we hypothesized that hyperinsulinemia could be responsible for this abnormality in b 3 AR function. The goal of this study was to determine whether lowering insulin with the K-ATP channel agonist, diazoxide (Dz) would reverse the depressed expression and function of the b 3 AR found in a model of diet-induced dia- betes and obesity in C57BL/6J (B6) mice. B6 male mice were placed on either high fat (HF) or low fat experimental diets. After 4 weeks, HF-fed mice were assigned to a group: HF or HF containing diso-dium ( R , R )-5-[2-([2-(3-chlorophenyl)-2-hydroxyethyl]-amino]pro- pyl-1,3-benzodioxole-2,2-dicarboxylate (CL; 0.001%, wt/wt), Dz (0.32%, wt/wt), or their combination (CLDz). Dz animals exhibited significantly reduced plasma insulin levels as well as increased b 3 AR expression and agonist-stimulated adenylyl cyclase activity in adi- pocytes. CLDz was more effective in reducing percent body fat, lowering nonesterified fatty acids, improving glucose tolerance, and re- ducing feed efficiency than either treatment alone. ( Endocrinology 3630–3637,
Concerning the Identification of Buried Dielectric Targets.

Abstract : For identifying dielectric targets buried in a lossy dielectric such as soil, one can use the natural frequencies as a signature. However, these are dependent not only on the constitutive parameters of the target, but also on those of the surrounding medium. For frequencies above the relaxation frequency of the medium (the high-frequency window) and for the relative dielectric constant Er of the target (relative to the external medium) sufficiently small one can evaluate the natural frequencies as perturbations based on the asymptotics for Er approaches 0. This gives a set of external resonances dominated by the external medium parameters, and a set of internal resonances dominated by the internal medium parameters. The latter are cavity resonances with damping from the external medium proportional to Er(1/2).
Noise dressing of the correlation matrix of factor models

We study the spectral density of factor models of multivariate time series. By making use of the Random Matrix Theory we analytically quantify the effect of noise dressing on the spectral density due to the finiteness of the sample. We consider a broad range of models ranging from one factor models in time and frequency domain to hierarchical multifactor models.
Assessing human appropriation of net primary production in various vegetation types based 1 on the spatio-temporal fusion model in New Area during 2000-2018

5 Background: Humans have induced great changes in terrestrial ecosystems. The 6 human appropriation of net primary production (HANPP) quantifying the intensity of 7 anthropogenic extraction from ecosystem has been widely used to evaluate ecological 8 sustainable development. However, the coarse-resolution of calculating data for the 9 HANPP leads to biased results in a small scale. Furthermore, the spatio-temporal 10 patterns and dynamics of the HANPP in a human-dominated heterogeneous region are 11 still unclear. 12 Methods: This study investigates the state-level new area Xiong'an New Area and 13 applies the improved enhanced spatial and temporal adaptive reflectance fusion model 14 (ESTARFM) to generated new datasets, which is combined with our previously 15 improved Carnegie–Ames–Stanford approach (CASA) to estimate HANPP. Spatio- 16 temporal variations of HANPP are mapped and assessed using Mann–Kendall (M–K) 17 trend analysis approach from 2000 to 2018 with a high resolution. The relationship 18 among the HANPP, subcomponents, and natural–social–economic-driven factors is 19 discussed herein. 20 Results: The results show that the improved ESTARFM-derived fusion images fitted 21 well with the observed images having the superior correlation coefficient (r), structural 22 similarity index, root mean square error, and mean absolute deviation of 0.75, 0.76, 23 0.035, and 0.026, respectively, and the normalized difference vegetation index (NDVI) 24 differences are mainly concentrated on the range of 0–0.15 for all months. The HANPP 25 derived by the fusion-based images, above 60% of potential NPP, varied across the 26 whole area, especially between various vegetation types. The HANPP exhibited a 27 significant positive correlation (r > 0.46, P < 0.05) with precipitation and held an 28 uptrend because of the increase of the harvested HANPP which related with the socio- 29 economic conditions having the determination coefficients above 0.76. 30 Conclusions: The spatio-temporal fusion contributed to fine spatial patterns and trends 31 of HANPP among various vegetation types. Though the harvested HANPP increased 32 from 2000 to 2018, the agricultural and socio-economic developments did not bring 33 extensive HANPP growth, indicating that the expansion has not violated its sustainable 34 development goal. The results provide a deep insight of the background characteristics 35 in Xiong'an New Area, which has great potential in supporting the future scientific 36 construction of the new area. 37
A review of current low vision services in Alberta.

Andrew Swift1*, Yejun Hong1, Colleen Schreiber2, Micah Luong3, Samuel N Markowitz4 1Cumming School of Medicine, University of Calgary, Calgary, Canada 2Rockyview General Hospital Eye Clinic, Calgary, Canada 3Section of Ophthalmology, Department of Surgery, University of Calgary, Calgary, Canada 4Low Vision Rehabilitation Fellowship Director, Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
AMEP_A_314644 769..777

1Medical Education Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt; 2Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Suez Canal University, Ismailia, Egypt Purpose: Learning focus has shifted from conventional teacher-centered to student-centered; therefore, methods used to support and encourage learners must be considered. Meanwhile, the individual differences between learners should be taken into consideration by medical educators. Aiming to achieve a better learning experience, the current study investigates the relationship between personality traits and learning styles and their effect on students’ academic achievement. Subjects and Methods: An analytical, cross-sectional study, encompassing a sample of 333 undergraduate first-year medical students, at the Faculty of Medicine, Suez Canal University in Egypt was conducted. The Big Five personality traits test and VARK learning styles questionnaires were used to assess students’ personality traits and learning styles, respectively, in the medical education module which is a part of the Foundation II module. The former is five weeks’ duration and is followed by a summative exam at the end. Students’ academic achievement was determined from their grades in Foundation II module by the end of the semester. Results: Study findings generally indicate that the highest domain of learning styles among students is the kinesthetic domain. A statistically significant difference between males and females regarding their learning style preferences was detected. Also, there was a statistically significant relationship between auditory and kinesthetic learning styles and academic achievement. Though there was a significant relationship between kinesthetic learning style with both openness traits and academic achievement, no significant statistical relationship was found between any of the personality traits and academic achievement. Conclusion: This study concludes that learning style could affect students’ academic achievement. It reveals that the kinesthetic learning style is the most preferred learning style among our medical students, also the agreeableness and openness traits were the most common personality traits among them. No significant relationship was detected between personality traits and academic achievement.
Introductory Chapter: Understanding Wavelets Introductory Chapter: Understanding Wavelets

In this section, let us discuss some fundamentals which are required to understand wavelets. Signals which are coming from a source are normally in time domain. Examples are sinusoidal signal, bio-medical signal, etc. Anytime domain signal can be processed or transformed into frequency domain (spectral domain) using mathematical transformations. Fourier transform is one of the popular or famous transform that will convert a time domain signal into frequency domain signal without any loss of generality.
Final Project Mimicking Human Vision by Photo-stimulation of Blind Retinas based on NR-CNT sensor

The goal of this project is to present an idea to mimic the human vision i.e. the development of electronic eyes or Bionic Eyes with the aid of a nanosensor. In this project the progress made in the field of visual prosthesis, particularly in the photo-stimulation of a blind retina with the help of nanotechnology is discussed. A wire-free photo-reception approach has been adopted. A novel structure for the retinal photo-stimulation, based on a combination of two nanomaterial systems ideally suited for neurostimulation: semiconductor nanorods (NRs) and carbon nanotubes (CNTs) has been presented. The complete design paradigm along with the fabrication techniques adopted and the complete characterization of such complex optoelectronic systems has been given. It is our belief that successful stimulation of such a light-sensitive system suggests the potential use of these novel platform in future artificial retina applications. X-ray photoelectron (XPS) chemical analysis of pristine (continuous line) and ppAA coated CNT film (dashed demonstrating the formation of carboxylic groups. We see that in Part (c) a SEM image of a ppAA coated CNT film demonstrating preservation of porous structure; the scale bar is 200 nm. Part (d) depicts the absorption (continuous line) and emission (dashed line) spectrum of the CdSe/CdS NRs; where the scale bar is 20 nm. Part (e) provides us a SEM image of a NR − CNT film; the scale bar being 100 nm. NRs appear as bright elongated elements on the CNTs.
Enhancement of Th17 NC/Nga Mice via Suppression of Th2 and Ameliorates Allergic Skin Inflammation of Pyridone 6, a Pan-JAK Inhibitor,

Atopic dermatitis (AD) is a common pruritic inﬂammatory disease triggered by a defective skin barrier and immunodysregula-tion. AD has been considered a typical example of a Th2 response associated with allergic disease. In the early phases of the disease, symptoms include IgE hyperproduction, eosinophil accumulation, and mast cell activation; in the chronic phase, a Th1-dominant immune response is also observed at the sites of AD skin lesions. The role of IL-17–producing Th (Th17) cells in AD has not been established. In the current study, we found that pyridone 6 (P6), a pan-JAK inhibitor, delayed the onset and reduced the magnitude of skin disease in an AD-like skin-disease model of NC/Nga mice. P6 reduced IFN- g and IL-13, whereas it enhanced IL-17 and IL-22 expression. In vitro, P6 also inhibited both Th1 and Th2 development, whereas it promoted Th17 differentiation from naive T cells when present within a certain range of concentrations. This was probably because P6 strongly inhibited STAT1, STAT5, and STAT6 phosphorylation, whereas STAT3 phosphorylation was less efﬁciently suppressed by P6 at the same concentration. Furthermore, IL-22 protects keratinocytes from apoptosis induced by IFN- g , and administration of IL-17 and IL-22 partially ameliorated skin diseases in NC/Nga mice. These results suggested that the JAK inhibitor P6 is therapeutic for AD by modulating the balance of Th2 and Th17. The Journal of Immunology ,
The hybrid curvaton

We study both oscillating and inflating curvaton scenarios when the curvaton mechanism is caused by a hybrid potential. The source of the curvature perturbation is the inhomogeneous phase transition that causes the modulation of the onset of the oscillation. For the supergravity-motivated curvaton there is a possibility of finding natural coincidence of the energy density that is needed to affect non-Gaussianity in the curvaton scenario.
Study the Throughput Outcome of Desktop Cloud Systems Using DesktopCloudSim Tool

— Desktop Cloud computing is a new type of Cloud computing that aims to provide Cloud services at little or no cost. This ambition can be achieved by combining Cloud computing and Volunteer computing into Desktop Clouds, harnessing non-dedicated resources when idle. However, Desktop Cloud systems suffer from the issue of node failures. Node failure can happen without prior notification, which may affect the throughput outcome of these systems. This paper studies the impact of node failures using a simulation tool. Simulation tools are commonly used by academics and researchers to simulate Clouds in order to investigate various research issues and examine proposed solutions. CloudSim is a well-known and widely employed tool to simulate Cloud computing by both academia and industry. However, CloudSim lacks the ability to simulate failure events, which may occur to physical nodes in the infrastructure level of a Cloud system. In order to show the effectiveness of DesktopCloudSim, we evaluate the throughput of two types of Desktop Clouds: private and public Desktop Clouds that are built on top of faulty nodes based on empirical data sets. The data sets are analysed and studied in this paper to reflect the number of node failures in these two Cloud types. The evaluation process serves two purposes: the first is that it validate the working of the proposed tool. The second is to show that throughput of Desktop Cloud systems is affected badly by node failures.
Classifying the Courses of Schizophrenia 519

The purpose of this review was to examine current strategies for classifying the courses of schizophrenia. Although a number of course classifications have evolved over the past two decades, the field has not addressed fully the complex issue of course description. This review compared previously published prototypes for describing the longterm courses of schizophrenia to identify variations and consistencies in course descriptions. Across investigations, differences were found in the number of courses described, in the structure of course categories, in the relative emphasis on syndrome symptoms versus syndrome change, and in documenting specific course features (i.e., illness onset, illness outcome, and types of symptoms). Interstudy comparisons of long-term illness patterns therefore are limited and cumulative statements on prognosis will remain problematic until some standardization is introduced. A minimal set of course parameters that should be documented in future studies include (1) the rate of syndrome onset; (2) postonset patterns of psychotic and residual symptoms;
Efﬁcient Antibody Production upon Suppression of O Mannosylation in the Yeast Ogataea minuta (cid:1)

When antibodies were expressed in the methylotrophic yeast Ogataea minuta , we found that abnormal O mannosylation occurred in the secreted antibody. Yeast-speciﬁc O mannosylation is initiated by the addition of mannose at serine (Ser) or threonine (Thr) residues in the endoplasmic reticulum via protein O mannosyltransferase (Pmt) activity. To suppress the addition of O-linked sugar chains on antibodies, we examined the possibility of inhibiting Pmt activity by the addition of a Pmt inhibitor during cultivation. The Pmt inhibitor was found to partially suppress the O mannosylation on the antibodies. Surprisingly, the suppression of O mannosylation was associated with an increased amount of assembled antibody (H2L2) and enhanced the antigen-binding activity of the secreted antibody. In this study, we demonstrated the expression of human antibody in O. minuta and elucidated the relationship between O mannosylation and antibody production in yeast.
REPORT Neuroanatomical precursors of dyslexia identiﬁed from pre-reading through to age 11

In this study, we acquired structural magnetic resonance imaging scans longitudinally from 27 Norwegian children from before formal literacy training began until after dyslexia was diagnosed. Thus, we were able to determine that the primary neuroanatomical abnormalities that precede dyslexia are not in the reading network itself, but rather in lower-level areas responsible for auditory and visual processing and core executive functions. Abnormalities in the reading network itself were only observed at age 11, after children had learned how to read. The ﬁndings suggest that abnormalities in the reading network are the consequence of having different reading experiences, rather than dyslexia per se, whereas the neuroanatomical precursors are predominantly in primary sensory cortices.
Gram-Negative Pneumonia Activation Impairs Host Defense against Ablation of Leptin Receptor-Mediated ERK

The adipocyte-derived hormone leptin plays an important role in regulation of energy homeostasis and the innate immune response against bacterial infections. Leptin’s actions are mediated by signaling events initiated by phosphorylation of tyrosine residues on the long form of the leptin receptor. We recently reported that disruption of leptin receptor-mediated STAT3 activation augmented host defense against pneumococcal pneumonia. In this report, we assessed leptin receptor-mediated ERK activation, a pathway that was ablated in the l/l mouse through a mutation of the tyrosine 985 residue in the leptin receptor, to determine its role in host defense against bacterial pneumonia in vivo and in alveolar macrophage (AM) antibacterial functions in vitro. l/l mice exhibited increased mortality and impaired pulmonary bacterial clearance after intratracheal challenge with Klebsiella pneumoniae . The synthesis of cysteinyl-leukotrienes was reduced and that of PGE 2 enhanced in AMs in vitro and the lungs of l/l mice after infection with K. pneumoniae in vivo. We also observed reduced phagocytosis and killing of K. pneumoniae in AMs from l/l mice that was associated with reduced reactive oxygen intermediate production in vitro. cAMP, known to suppress phagocytosis, bactericidal capacity, and reactive oxygen intermediate production, was also increased 2-fold in AMs from l/l mice. Pharmacologic blockade of PGE 2 synthesis reduced cAMP levels and overcame the defective phagocytosis and killing of bacteria in AMs from l/l mice in vitro. These results demonstrate that leptin receptor-mediated ERK activation plays an essential role in host defense against bacterial pneumonia and in leukocyte antibacterial effector functions. The Journal of Immunology , 2012,