Miracle-dz/UniFAR-FTUs huggingface dataset:
Plasma scale length and quantum electrodynamics effects on particle acceleration at extreme laser plasmas

In this work, simulations of multipetawatt lasers at irradiances ${\sim }10^{23} \ \mathrm {W}\ \mathrm {cm}^{-2}$, striking solid targets and implementing two-dimensional particle-in-cell code was used to study particle acceleration. Preformed plasma at the front surface of a solid target increases both the efficiency of particle acceleration and the reached maximum energy by the accelerated charged particles via nonlinear plasma processes. Here, we have investigated the preformed plasma scale length effects on particle acceleration in the presence and absence of nonlinear quantum electrodynamic (QED) effects, including quantum radiation reaction and multiphoton Breit–Wheeler pair production, which become important at irradiances ${\sim } 10^{23}\ \mathrm {W}\ \mathrm {cm}^{-2}$. Our results show that QED effects help particles gain higher energies with the presence of preformed plasma. In the results for all cases, preplasma leads to more efficient laser absorption and produces more energetic charged particles, as expected. In the case where QED is included, however, physical mechanisms changed and generated secondary particles ($\gamma$-rays and positrons) reversing this trend. That is, the hot electrons cool down due to QED effects, while ions gain more energy due to different acceleration methods. It is found that more energetic $\gamma$-rays and positrons are created with increasing scale length due to high laser conversion efficiency (${\sim }$24 % for $\gamma$-rays and $\sim$4 % for positrons at $L = 7\ \mathrm {\mu }\textrm {m}$ scale length), which affects the ion and electron acceleration mechanisms. It is also observed that the QED effect reduces the collimation of angular distribution of accelerated ions because the dominant ion acceleration mechanism is changing when QED is involved in the process.
Romosozumab improves lumbar spine bone mass and bone strength parameters relative to alendronate in postmenopausal women: results from the Active‐Controlled Fracture Study in Postmenopausal Women With Osteoporosis at High Risk (ARCH) trial

The Active‐Controlled Fracture Study in Postmenopausal Women With Osteoporosis at High Risk (ARCH) trial (NCT01631214; https://clinicaltrials.gov/ct2/show/NCT01631214) showed that romosozumab for 1 year followed by alendronate led to larger areal bone mineral density (aBMD) gains and superior fracture risk reduction versus alendronate alone. aBMD correlates with bone strength but does not capture all determinants of bone strength that might be differentially affected by various osteoporosis therapeutic agents. We therefore used quantitative computed tomography (QCT) and finite element analysis (FEA) to assess changes in lumbar spine volumetric bone mineral density (vBMD), bone volume, bone mineral content (BMC), and bone strength with romosozumab versus alendronate in a subset of ARCH patients. In ARCH, 4093 postmenopausal women with severe osteoporosis received monthly romosozumab 210 mg sc or weekly oral alendronate 70 mg for 12 months, followed by open‐label weekly oral alendronate 70 mg for ≥12 months. Of these, 90 (49 romosozumab, 41 alendronate) enrolled in the QCT/FEA imaging substudy. QCT scans at baseline and at months 6, 12, and 24 were assessed to determine changes in integral (total), cortical, and trabecular lumbar spine vBMD and corresponding bone strength by FEA. Additional outcomes assessed include changes in aBMD, bone volume, and BMC. Romosozumab caused greater gains in lumbar spine integral, cortical, and trabecular vBMD and BMC than alendronate at months 6 and 12, with the greater gains maintained upon transition to alendronate through month 24. These improvements were accompanied by significantly greater increases in FEA bone strength (p < 0.001 at all time points). Most newly formed bone was accrued in the cortical compartment, with romosozumab showing larger absolute BMC gains than alendronate (p < 0.001 at all time points). In conclusion, romosozumab significantly improved bone mass and bone strength parameters at the lumbar spine compared with alendronate. These results are consistent with greater vertebral fracture risk reduction observed with romosozumab versus alendronate in ARCH and provide insights into structural determinants of this differential treatment effect. © 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Therapeutic Development by Targeting the cGAS-STING Pathway in Autoimmune Disease and Cancer

DNA immune recognition regulation mediated by the cGAS-STING pathway plays an important role in immune functions. Under normal physiological conditions, cGAS can recognize and bind to invading pathogen DNA and activate the innate immune response. On the other hand, abnormal activation of cGAS or STING is closely related to autoimmune diseases. In addition, activation of STING proteins as a bridge connecting innate immunity and adaptive immunity can effectively restrain tumor growth. Therefore, targeting the cGAS-STING pathway can alleviate autoimmune symptoms and be a potential drug target for treating cancer. This article summarizes the current progress on cGAS-STING pathway modulators and lays the foundation for further investigating therapeutic development in autoimmune diseases and tumors.
What's the Cost? Measuring the Economic Impact of Pediatric Sepsis

Sepsis, life-threatening organ dysfunction secondary to infection, hospitalizes nearly 75,000 children each year in the United States. Most children survive sepsis. However, there is increasing recognition of the longer-term consequences of pediatric sepsis hospitalization on both the child and their family, including medical, psychosocial, and financial impacts. Here, we describe family spillover effects (the impact of illness on caregivers) of pediatric sepsis, why measurement of family spillover effects is important, and the ways in which family spillover effects can be measured.
The Research Progress in Immunotherapy of Tuberculosis

Tuberculosis (TB) is a serious public health problem worldwide. The combination of various anti-TB drugs is mainly used to treat TB in clinical practice. Despite the availability of effective antibiotics, effective treatment regimens still require long-term use of multiple drugs, leading to toxicity, low patient compliance, and the development of drug resistance. It has been confirmed that immune recognition, immune response, and immune regulation of Mycobacterium tuberculosis (Mtb) determine the occurrence, development, and outcome of diseases after Mtb infection. The research and development of TB-specific immunotherapy agents can effectively regulate the anti-TB immune response and provide a new approach toward the combined treatment of TB, thereby preventing and intervening in populations at high risk of TB infection. These immunotherapy agents will promote satisfactory progress in anti-TB treatment, achieving the goal of “ultra-short course chemotherapy. ” This review highlights the research progress in immunotherapy of TB, including immunoreactive substances, tuberculosis therapeutic vaccines, chemical agents, and cellular therapy.
Technological and Safety Characterization of Kocuria rhizophila Isolates From Traditional Ethnic Dry-Cured Ham of Nuodeng, Southwest China

Nuodeng ham is known for its unique processing techniques and flavor. In the present study, proteolytic microorganisms from cured artisanal Nuodeng ham were investigated in order to identify and select potential starter cultures for its faster and safer fermentation. Eight isolates, accounting for 57% of proteolytic microorganisms, were found to be related to Kocuria rhizophila. Relevant properties of K. rhizophila as potential starter culture were evaluated in vitro for the first time. Intra-species diversities were found in phylogenetic and physiological properties of K. rhizophila isolates. Nevertheless, desirable attributes, such as halo-tolerance, nitrate reductase and protease activity, as well as the absence of antimicrobial resistance and amino acid decarboxylase activity, were observed in selected isolates. Moreover, genome analysis of isolates K24 and K45 confirmed their lack of typical genes for virulence, antimicrobial resistance and amino acid decarboxylase. K. rhizophila may thus represent a novel starter candidate of coagulase-negative cocci group and contribute to color and flavor development of fermented meats.
Obvious Surface States Connecting to the Projected Triple Points in NaCl’s Phonon Dispersion

With the development of computer technology and theoretical chemistry, the speed and accuracy of first-principles calculations have significantly improved. Using first-principles calculations to predict new topological materials is a hot research topic in theoretical and computational chemistry. In this work, we focus on a well-known material, sodium chloride (NaCl), and propose that the triple point (TP), quadratic contact triple point (QCTP), linear and quadratic nodal lines can be found in the phonon dispersion of NaCl with Fm 3 ¯ m type structure. More importantly, we propose that the clear surface states connected to the projected TP and QCTP are visible on the (001) surface. It is hoped that further experimental investigation and verification for these properties as mentioned above.
Characterization of Awp14, A Novel Cluster III Adhesin Identified in a High Biofilm-Forming Candida glabrata Isolate

Candida glabrata is among the most prevalent causes of candidiasis. Unlike Candida albicans, it is not capable of changing morphology between yeast and hyphal forms but instead has developed other virulence factors. An important feature is its unprecedented large repertoire of predicted cell wall adhesins, which are thought to enable adherence to a variety of surfaces under different conditions. Here, we analyzed the wall proteome of PEU1221, a high biofilm-forming clinical strain isolated from an infected central venous catheter, under biofilm-forming conditions. This isolate shows increased incorporation of putative adhesins, including eight proteins that were not detected in walls of reference strain ATCC 2001, and of which Epa22, Awp14, and Awp2e were identified for the first time. The proteomics data suggest that cluster III adhesin Awp14 is relatively abundant in PEU1221. Phenotypic studies with awp14Δ deletion mutants showed that Awp14 is not responsible for the high biofilm formation of PEU1221 onto polystyrene. However, awp14Δ mutant cells in PEU1221 background showed a slightly diminished binding to chitin and seemed to sediment slightly slower than the parental strain suggesting implication in fungal cell-cell interactions. By structural modeling, we further demonstrate similarity between the ligand-binding domains of cluster III adhesin Awp14 and those of cluster V and VI adhesins. In conclusion, our work confirms the increased incorporation of putative adhesins, such as Awp14, in high biofilm-forming isolates, and contributes to decipher the precise role of these proteins in the establishment of C. glabrata infections.
Pulmonary Eosinophils at the Center of the Allergic Space-Time Continuum

Eosinophils are typically a minority population of circulating granulocytes being released from the bone-marrow as terminally differentiated cells. Besides their function in the defense against parasites and in promoting allergic airway inflammation, regulatory functions have now been attributed to eosinophils in various organs. Although eosinophils are involved in the inflammatory response to allergens, it remains unclear whether they are drivers of the asthma pathology or merely recruited effector cells. Recent findings highlight the homeostatic and pro-resolving capacity of eosinophils and raise the question at what point in time their function is regulated. Similarly, eosinophils from different physical locations display phenotypic and functional diversity. However, it remains unclear whether eosinophil plasticity remains as they develop and travel from the bone marrow to the tissue, in homeostasis or during inflammation. In the tissue, eosinophils of different ages and origin along the inflammatory trajectory may exhibit functional diversity as circumstances change. Herein, we outline the inflammatory time line of allergic airway inflammation from acute, late, adaptive to chronic processes. We summarize the function of the eosinophils in regards to their resident localization and time of recruitment to the lung, in all stages of the inflammatory response. In all, we argue that immunological differences in eosinophils are a function of time and space as the allergic inflammatory response is initiated and resolved.
Fusion of Ladybug3 omnidirectional camera and Velodyne Lidar

The advent of autonomous vehicles expedites the revolution of car industry. Volvo Car Corporation has an ambition of developing the next generation of autonomous vehicle. In the Volvo Car Corporation, Active Safety CAE group, enthusiastic engineers have initiated a series of relevant research to enhance the safety function for autonomous vehicle and this thesis work is also implemented at Active Safety CAE with their support. Perception of vehicle plays a pivotal role in autonomous driving, therefore an idea of improving vision by fusing two different types of data from Velodyne HDL-64E S3 High Definition LiDAR Sensor and Ladybug3 camera respectively, is proposed. This report presents the whole process of fusion of point clouds and image data. An experiment is implemented for collecting and synchronizing multi-sensor data streams by building a platform which supports the mounting of Velodyne, Ladybug 3 and their accessories, as well as the connection to GPS unit, laptop. Related software/programming environment for recording, synchronizing and storing data will also be mentioned.Synchronization is mainly achieved by matching timestamps between different datasets. Creating log files for timestamps is the primary task in synchronization.External Calibration between Velodyne and Ladybug3 camera for matching two different datasets correctly is the focus of this report. In the project, we will develop a semi-automatic calibration method with very little human intervention using a checkerboard for acquiring a small set of feature points from laser point cloud and image feature correspondences. Based on these correspondences, the displacement is computed. Using the computed result, the laser points are back-projected into the image. If the original and back-projected images are sufficiently consistent, then the transformation parameters can be accepted. Displacement between camera and laser scanner are estimated through two separate steps: first, we will estimate the pose for the checkerboard in image and get its depth information in camera coordinate system; and then a transformation relation between the camera and the laser scanner will be computed within three dimensional space. Fusion of datasets will finally be done by combing color information from image and range information from point cloud together. Other applications related to data fusion will be developed as the support of future work. In the end, a conclusion will be drawn. Possible improvements are also expected in future work. For example, better accuracy of calibration might be achieved with other methods and adding texture to cloud points will generate a more realistic model.
Precise SAR Measurements In The Near-Field of RF Antenna Systems

Title of dissertation: PRECISE SAR MEASUREMENTS IN THE NEAR-FIELD OF RF ANTENNA SYSTEMS Bandar M. Hakim, Doctor of Philosophy, 2006 Dissertation directed by: Professor Christopher C. Davis Department of Electrical and Computer Engineering Wireless devices must meet specific safety radiation limits, and in order to assess the health affects of such devices, standard procedures are used in which standard phantoms, tissueequivalent liquids, and miniature electric field probes are used. The accuracy of such measurements depend on the precision in measuring the dielectric properties of the tissueequivalent liquids and the associated calibrations of the electric-field probes. This thesis describes work on the theoretical modeling and experimental measurement of the complex permittivity of tissue-equivalent liquids, and associated calibration of miniature electric-field probes. The measurement method is based on measurements of the field attenuation factor and power reflection coefficient of a tissue-equivalent sample. A novel method, to the best of the authors knowledge, for determining the dielectric properties and probe calibration factors is described and validated. The measurement system is validated using saline at different concentrations, and measurements of complex permittivity and calibration factors have been made on tissue-equivalent liquids at 900MHz and 1800MHz. Uncertainty analysis have been conducted to study the measurement system sensitivity. Using the same waveguide to measure tissue-equivalent permittivity and calibrate e-field probes eliminates a source of uncertainty associated with using two different measurement systems. The measurement system is used to test GSM cell-phones at 900MHz and 1800MHz for Specific Absorption Rate (SAR) compliance using a Specific Anthropomorphic Mannequin phantom (SAM). PRECISE SAR MEASUREMENTS IN THE NEAR-FIELD OF RF ANTENNA SYSTEMS
A Serum Biomarker Panel of exomiR-451a, exomiR-25-3p and Soluble TWEAK for Early Diagnosis of Rheumatoid Arthritis

Background The etiology of rheumatoid arthritis (RA) remains poorly understood. Early and accurate diagnosis still difficult to achieve. Inflammatory related molecules released into the circulation such cytokines and exosome-derived microRNAs (exomiRNAs) could be good candidates for early diagnosis of autoimmune diseases. We sought to discover a serum biomarker panel for the early detection of RA based on exomiRNAs and inflammatory markers. Methods A 179 miRNAs-microarray panel was analyzed in a pilot study (4 early RA and 4 controls). Validation of deregulated exomiRNAs was performed in a larger cohort (24 patients with early RA and 24 controls). miRNet software was used to predict exomiRNA gene-targets interactions. Potentially altered pathways were analyzed by Reactome pathway database search. STRING database was used to predict protein-protein interaction networks. Enzyme-linked immunosorbent assay was used to measure serum levels of sTWEAK and sCD163. Signature biomarker candidates were statistical analyzed. Results We detected 11 differentially expressed exomiRNAs in early RA pilot study. Validation analysis revealed that 6/11 exomiRNAs showed strong agreement with the pilot microarray data (exomiR-144-3p, -25-3p, -15a-5p, -451a, -107 and -185-5p). sTWEAK and sCD163 biomarkers were significantly elevated in the serum of patients with early RA. Receiver operating characteristic (ROC) analysis showed that the best panel to diagnose early RA contained exomiR-451a, exomiR-25-3p and sTWEAK, and could correctly classify 95.6% of patients, with an area under the ROC curve of 0.983 and with 100% specificity and 85.7% sensitivity. The YWHAB gene was identified as a common target of the putative miRNA-regulated pathways. Conclusion A novel serum biomarker panel composed of exomiR-451a, exomiR-25-3p and serum levels of sTWEAK may have use in the early clinical diagnosis of RA. A new predicted exomiRNA-target gene YHWAB has been identified and may have a relevant role in the development of RA.
A novel broadband reflectarray antenna with lattice stubs on square element for Ku‐band application

In this article, a single layer unit cell reflectarray antenna comprising a fixed square patch to which is attached a lattice of symmetric open ended stubs is proposed. The phase response of the proposed unit cell element is governed by the length of the lattice, providing more than 600° of reflection phase variation. The unit cell element of 0. 54λ0 × 0. 54λ0, has a thin dielectric substrate thickness of 0. 036λ0 and is placed above an air layer making the overall unit cell thickness of 0. 126λ0. A 15 × 15 elements Ku‐band reflectarray antenna is designed with an area of 18 × 18 cm2. The reflectarray is center fed by a linearly polarized pyramidal horn antenna. The planar reflectarray antenna is fabricated and has wide −1 dB gain bandwidth, about 20% covering 12.1–14.8 GHz. The measured antenna gain at 13.5 GHz is 25 dB which is equivalent to 39% efficiency. The proposed unit cell and the reflectarray antenna are simulated through CST and HFSS software packages. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 55:2699–2702, 2015
The Relationship Between Perceived Leader Busyness and Perspective Taking and Interaction Behavior of Followers

How leaders influence followers have been a hot topic in both research and practice. Yet, prior studies have primarily focused on the impact of one leadership style, while overlooking how a leadership role may influence behavioral expressions of leaders. Particularly, being a leader means having to face time demands and workload pressure, and thus, busyness becomes a common phenomenon for leaders. Focused on perceived leader busyness, we had examined how it may influence employee interactions with leaders and how those interactions influenced leader evaluations of the performance of followers. Based on sensemaking theory, we propose that when followers have a high level of perspective taking, they are more likely to take avoidance behavior when perceiving leaders as of high busyness. Further, when followers engage in interaction avoidance behavior, leaders may consider followers as hiding errors or intentionally concealing their work process, which reduces positive evaluations (i.e., task performance and conscientiousness evaluation) while enhancing negative evaluation (i.e., deviance behavior) toward followers. We conducted two studies. Study one was conducted with a 25 participants interview and data of 297 employees to show scale validity of perceived leader busyness. Study two was conducted with 377 employees and their direct supervisors. Applying the complex modeling method, we found that followers with low-level perspective taking are less likely to engage in interaction avoidance behavior, even when perceiving leaders as high busyness; interaction avoidance behavior of followers has a positive relationship with counterproductive behavior evaluation of leaders, but a negative relationship with conscientiousness behavior evaluation. This study enriches the dyadic interactions between leaders and followers. In addition, it also shows the burden of perspective taking.
Development and Validation of a Prediction Model for Acute Kidney Injury Among Patients With Acute Decompensated Heart Failure

Background: Acute kidney injury is an adverse event that carries significant morbidity among patients with acute decompensated heart failure (ADHF). We planned to develop a parsimonious model that is simple enough to use in clinical practice to predict the risk of acute kidney injury (AKI) occurrence. Methods: Six hundred and fifty patients with ADHF were enrolled in this study. Data for each patient were collected from medical records. We took three different approaches of variable selection to derive four multivariable logistic regression model. We selected six candidate predictors that led to a relatively stable outcome in different models to derive the final prediction model. The prediction model was verified through the use of the C-Statistics and calibration curve. Results: Acute kidney injury occurred in 42.8% of the patients. Advanced age, diabetes, previous renal dysfunction, high baseline creatinine, high B-type natriuretic peptide, and hypoalbuminemia were the strongest predictors for AKI. The prediction model showed moderate discrimination C-Statistics: 0.766 (95% CI, 0.729–0.803) and good identical calibration. Conclusion: In this study, we developed a prediction model and nomogram to estimate the risk of AKI among patients with ADHF. It may help clinical physicians detect AKI and manage it promptly.