Miracle-dz/UniFAR-FTUs huggingface dataset:
Advances and Trends in Omics Technology Development

The human history has witnessed the rapid development of technologies such as high-throughput sequencing and mass spectrometry that led to the concept of “omics” and methodological advancement in systematically interrogating a cellular system. Yet, the ever-growing types of molecules and regulatory mechanisms being discovered have been persistently transforming our understandings on the cellular machinery. This renders cell omics seemingly, like the universe, expand with no limit and our goal toward the complete harness of the cellular system merely impossible. Therefore, it is imperative to review what has been done and is being done to predict what can be done toward the translation of omics information to disease control with minimal cell perturbation. With a focus on the “four big omics,” i.e., genomics, transcriptomics, proteomics, metabolomics, we delineate hierarchies of these omics together with their epiomics and interactomics, and review technologies developed for interrogation. We predict, among others, redoxomics as an emerging omics layer that views cell decision toward the physiological or pathological state as a fine-tuned redox balance.
Clinical Evaluation of Autologous and Allogeneic Stem Cell Therapy for Intrauterine Adhesions: A Systematic Review and Meta-Analysis

Objective Intrauterine adhesions (IUAs) are a major cause of female infertility. Stem cells can be used to restore endometrial function owing to their regenerative abilities. We compared the safety and efficacy of autologous and allogeneic stem cell treatments in patients with recurrent IUA after conventional therapy based on a systematic review of the related literature. Methods The PubMed, Embase, and Cochrane databases were systematically searched. All analysis were performed using Review Manager 5.4. We compared improvements in endometrial thickness, pregnancy rates, menstruation, and side effects after autologous and allogeneic stem cell therapy. The study was registered with PROSPERO, CRD 42022322870. Results Our search returned 154 reports, 10 of which met the inclusion criteria, representing 116 patients. Of these, 44 patients in two studies were treated with allogeneic stem cells and 72 patients in eight studies were treated with autologous stem cells. Improvements in endometrial thickness and pregnancy rates after intrauterine device treatment were compared between the autologous and allogeneic stem cell groups. Endometrial thickness increased more after autologous stem cell IUA treatment (mean difference, 1.68; 95% confidence interval [CI]: 1.30–2.07; P < 0.00001), and the pregnancy rate was also improved (relative risk, 1.55; 95% CI: 1.19–2.02, P < 0. 001). No obvious and serious adverse reactions were observed during stem cell therapy in either group. Conclusions This meta-analysis and systematic review of the results of randomized trials of autologous and allogeneic stem cell treatments for IUA suggests that autologous stem cells have a better effect in improving the endometrium thickness and pregnancy rate. Systematic Review Registration https://www.crd. york.ac. uk/PROSPERO/, identifier CRD42022322870.
Automated SEM Mineralogy and Archaeological Ceramics: Applications in Formative Period Pottery From the Atacama Desert

The analysis of archaeological ceramics has rapidly evolved over the last decades by the application of new analytical techniques. An emerging analytical proposal to fully characterise archaeological ceramics using automated SEM mineralogy is presented. A case study is provided of sets of ceramics from the San Pedro de Atacama oases in the Atacama Desert, northern Chile. Ceramic fragments of different typologies (i.e., Los Morros, Loa Café Alisado and San Pedro Negro Pulido) found in the Ghatchi archaeological sites are analysed. Our results include automated mineralogical maps, which are used to define the components that form the ceramic pastes, i.e., clay matrix and non-plastic inclusions, as well as grain size and mineral abundance information. We show that the pastes that define the studied ceramic types are more complex than previously suggested. The overall composition for these pastes corresponds to clay mineral-rich matrices containing non-plastic inclusions, such as mineral grains, crushed ceramic fragments, and sedimentary to igneous rock fragments, that may vary in composition, size, and abundance among the studied ceramic types. This mineralogical information allows us to discuss possible sources of raw materials by comparing these paste components with geological information. Here we interpret Los Morros and Loa Café Alisado as foreign ceramic types to Ghatchi, whereas the San Pedro Negro Pulido fragments found in this site agree well with the pottery paste recipe typically recognised in the San Pedro de Atacama oases. The petrographic-approach employed here supports the automated SEM mineralogy as a valid option for archaeometric studies of ceramic pastes since includes precise quantitative data formulated from the chemical composition of each component of the paste, which may provide valuable evidence into raw materials and technological styles.
Nailfold Video Capillaroscopy in Pregnant Women With and Without Cardiovascular Risk Factors

Objective To evaluate microvasculature in pregnant women with and without cardiovascular risk factors. Design Cross-sectional, observational study. Population Women were recruited at the outpatient clinic for high risk prenatal care. Out of a total of 345 women assessed at first and/or second and/or third trimester, 169 women without and 176 with cardiovascular risk factors were included. Methods Nailfold video capillaroscopy (NVC) measurements were performed at magnification of 200x at all fingers except thumbs. Images were stored for offline measurement of capillary density (CDe) and capillary diameters (CDi). Maternal anthropometrics, obstetric, and medical history were used for categorization in low and high cardiovascular risk. Comparison between groups and trimesters, with respect to pregnancy outcome, was performed using linear mixed model analysis. Results Women with a high risk cardiovascular profile show higher CDe, regardless of pregnancy outcome. CDi drops during pregnancy, with lowest CDi in third trimester in patients with preeclampsia. Capillary bed (CB), as a composite of CDe and CDi, is stable during pregnancy in women with low risk cardiovascular profile. In women with high risk cardiovascular profile, CB drops from the first to the second trimester, regardless of pregnancy outcome. Only in women with pre-eclampsia, the CB is lower in the third trimester as compared to the first trimester. There is an inverse association between CDe and mean arterial pressure (MAP) in women with high cardiovascular risk and pre-eclampsia. Conclusion Microcirculation is altered during the course of pregnancy and microcirculatory behavior is different in patients with low and high cardiovascular risk profile, as well as in patients with preeclampsia.
Discussing the Effect of Students' Crisis Awareness on Emotion During the COVID-19 Pandemic From the Perspective of Trust

The effects of crises vary among individuals, societies, and nations. Governments' crisis management is quite different from that of non-governmental organizations, especially in terms of “publicity,” since it involves bureaucracy to address people's accountability concerns. The purpose of this study is to investigate the relationship between students' crisis awareness, trust, and emotions in the event of a major public health emergency. A questionnaire survey was conducted for this study. A total of 500 copies of questionnaires were distributed to the college students in Jiangxi. Among those, 437 valid copies were retrieved, with a retrieval rate of 87%. A structural equation model (SEM) was used to conduct the statistical analyses. The research results were summarized as follows: (1) At the stage of epidemic spread, people can easily fall into the negative emotion. (2) The society with a good trust relationship considers schools less responsible for critical incidents and more helpful for crisis communication. (3) Reducing the negative emotions of the public after the occurrence of critical incidents can effectively reduce the damage of critical incidents to the organization. Avoiding a loss of student confidence and increasing anger, protecting the school's reputation, having a good communication effect, and minimizing the impact of the crisis can help the students develop better trust toward the school. When a crisis occurs on campus, this can reduce the possibility of students' showing negative emotions and spreading rumors. It is considered that the findings provide guidance on how to optimize the management of public health crisis situations and improve students' mental health.
Mitigation of voltage swells in IEEE 30 bus and IEEE 57 bus systems using evolutionary techniques

The main objective of this research is to give as complete as possible analysis of voltage swell and their mitigation in power systems. This objective can be achieved by addressing several tasks in a step by step approach. For every voltage swell magnitude, evolutionary computing methods will be used to determine the parameters of the traditional FACTS like inductor and capacitor values and also these methods will be used to get the best values of PI controller gains connected to the traditional FACTS. So by formation of the variable inductance and capacitance FACTS with variable controller gains for each swell magnitude, we can introduce a new idea namely Advanced Flexible AC Transmission System (AFACTS) for a thorough study of the steady-state and dynamic operation of electrical power systems to improve the power systems quality by mitigating the voltage swell with any magnitude at the affected bus. In order to perform the above-mentioned studies and analysis effectively and accurately on a realistic size power system, an automated comprehensive tool is required for the assessment and visualization of the performance of voltage swell of individual buses and the entire network. RÉSUMÉ. L'objectif principal de cette recherche est de fournir une analyse aussi complète que possible la houle de la tension et son atténuation dans les systèmes d’alimentation électrique. Cet objectif peut être atteint en abordant plusieurs tâches de manière progressive. Pour chaque amplitude de la houle de tension, des méthodes de calcul d’évolution seront utilisées pour déterminer les paramètres des FACTS traditionnels, telles que les valeurs d'inductances et de condensateurs et ces méthodes seront également utilisées pour obtenir les meilleures valeurs de gains de contrôleur PI connectées aux FACTS traditionnels. Ainsi, par la formation des FACTS à inductance et à capacité variables avec des gains de contrôleur variables pour chaque amplitude de houle, nous pouvons introduire une nouvelle idée, à savoir le Système de Transmission CA flexible avancé (AFACTS) pour une étude approfondie du fonctionnement en régime permanent et dynamique des systèmes d'alimentation électrique dans le but d’améliorer la qualité des systèmes d'alimentation électrique en atténuant la houle de tension quelle que soit l'amplitude sur le bus affecté. Afin de réaliser les études et les analyses susmentionnées de manière efficace et précise sur un système électrique de taille réaliste, un outil complet 500 EJEE. Volume 20 – n° 4/2018 automatisé est nécessaire pour évaluer et visualiser les performances de la houle de tension de chaque bus et de l'ensemble du réseau.
Psychometric Properties of the Cyprus Lexical List in the Greek Language for Infants and Preschool Children and Preliminary Results

The aim of this study was to evaluate the psychometric properties of the adapted Cyprus Greek Lexical List a-CYLEX (GR) in a sample of 194 Greek toddlers from the island of Crete with Standard Modern Greek (SMG) as their primary language. The a-CYLEX (GR) is a parental report checklist for assessing the receptive and expressive vocabulary skills of children aged 12 months to 3:6 years. Concurrent validity of the instrument was tested via correlations with the adapted Greek version of the Receptive One-Word Picture Vocabulary Test-II (ROWPVT-II), which was administered to 124 SMG-speaking children between the ages of 2 and 3:6 years. Test–retest reliability was tested by administering the instrument two times within a 2-week interval to 59 parents (30.41% of the total sample). Statistical analyses provided strong evidence for the high internal consistency and test–retest reliability of the a-CYLEX (GR). The role of the demographic variables in vocabulary performance and the frequency of each a-CYLEX (GR) word category by age were also investigated. In conclusion, the a-CYLEX (GR) is a parental report checklist that can be used by clinicians who are interested in assessing receptive and expressive vocabulary of children during toddlerhood.
Riverine Barriers as Obstacles to Dispersal in Amazonian Birds

Amazonian rivers represent known barriers for avian dispersal, reducing gene flow and enhancing differentiation. Despite the importance of rivers in the avian evolutionary process, we have made only minor advances in understanding the limitations imposed by rivers on flying birds. To fill that gap, we conducted dispersal-challenge experiments over water, assessing the flying capabilities of 84 tropical bird species of 22 different avian families. We mist-netted and released 484 birds from a stationary boat on the Rio Branco, northern Amazonia, at increasing distances from the shore, including 249 individuals at 100; 219 at 200; 8 at 300; and 5 at 400 m. A successful trial was represented by a bird reaching the riverbank, whereas a failure would refer to birds not reaching the shore and landing on the water, when they were rescued by our team. Our main goal was to understand if the outcome in the experiments could be predicted by (i) phylogenetic constraints, (ii) morphology (body mass and wing shape), (iii) flight speed, (iv) ecological preferences (stratum, habitat, and river-island specialization), and (v) psychological reluctance to fly. Nearly two thirds of the individuals (332) were successful in reaching the riverbank, whereas 152 failed. We found significant differences among lineages. Whereas seven avian families succeeded in all of the trials, two families (antbirds and wrens) were particularly bad dispersers (<40% success). The hand-wing index (HWI) was the single most powerful predictor of trial success. Flying speed was also a significant predictor of success. Overall, ecological attributes had a low explanatory power. Only forest stratum preference had a significant, although weak, effect on dispersal ability: canopy- and ground-dwellers performed better than understory birds. However, we found no effect of habitat preference or river-island specialization on dispersal ability. Our speed estimates for 64 bird species are among the first produced for the tropics and suggest slower flying speeds than those reported from temperate migratory birds. Although birds showed behavioral differences when presented with the opportunity to fly away from the boat, we found no evidence that their reluctance to fly could predict the outcome in the experiments. This represents the first experimental study evaluating the riverine effect through dispersal ability of Amazonian birds, providing important insights to better understand dispersal limitations provided by riverine barriers.
The Location Privacy Protection of Electric Vehicles with Differential Privacy in V2G Networks

Vehicle-to-grid (V2G) is an important component of smart grids and plays a significant role in improving grid stability, reducing energy consumption and generating cost. However, while electric vehicles are being charged, it is possible to expose the location and movement trajectories of the electric vehicles, thereby triggering a series of privacy and security issues. In response to this problem, we propose a new quadtree-based spatial decomposition algorithm to protect the location privacy of electric vehicles. First of all, we use a random sampling algorithm, which is based on differential privacy, to obtain enough spatial data to achieve the balance between large-scale spatial data and the amount of noise. Secondly, in order to overcome the shortcomings of using tree height to control Laplacian noise in the quadtree, we use sparse vector technology to control the noise added to the tree nodes. Finally, according to the vehicle-to-grid network structure in the smart grid, we propose a location privacy protection model based on distributed differential privacy technology for EVs in vehicle-to-grid networks. We demonstrate application of the proposed model in real spatial data and show that it can achieve the best effect on the security of the algorithm and the availability of data.
Pointers to Interventions for Promoting COVID-19 Protective Measures in Tourism: A Modelling Approach Using Domain-Specific Risk-Taking Scale, Theory of Planned Behaviour, and Health Belief Model

Based on the factors of the Theory of Planned Behaviour (TPB), the Health Belief Model (HBM), and the DOSPERT scale, used to measure general risk-taking behaviour, a combined model has been developed for investigating tourists’ intentions to implement protective measures against the coronavirus disease 2019 (COVID-19). The purpose of the study is to formulate a model that Swiss tourism practitioners can use to understand tourists’ decision-making regarding the acceptance and proper implementation of non-pharmaceutical interventions (NPIs). A large-scale cross-sectional population study that is representative for the Swiss population has been designed to validate the model (N = 1,683; 39% response rate). In our empirical investigation, a simple regression analysis is used to detect significant factors and their strength. Our empirical findings show that the significant effects can be ordered regarding descending effect size from severity (HBM), attitude (TPB), perceived behavioural control (TPB), subjective norm (TPB), self-efficacy (HBM), and perceived barriers (HBM) to susceptibility (HBM). Based on this information, intervention strategies and corresponding protective measures were linked to the social-psychological factors based on an expert workshop. Low-cost interventions for tourists (less time, less money, and more comfort), such as the free provision of accessories (free mask and sanitizers) or free testing (at cable cars), can increase the perceived behavioural control and lower the perceived barriers and thus increase the acceptance of this protective measure.
Short-Term Prognostic Efficacy of mGPS and LCS in Patients With Acute Heart Failure

Aim Systemic inflammation plays an important role in the occurrence and development of acute heart failure. The modified Glasgow Prognostic Score (mGPS) and “lymphocyte C-reactive protein score” (LCS) are used to assess the inflammation levels in cancer patients. The purpose of this study was to assess the prognostic value of these two inflammation-related scoring systems in patients with acute heart failure. Methods Two hundred and fifty patients with acute heart failure were enrolled in this study. The mGPS and LCS scores were recorded after admission. All patients were divided into 2 groups: the death group and the survival group according to the 3-month follow-up results. The predictive values of mGPS and LCS were assessed using receiver-operating characteristic (ROC) analyses. Univariate and multivariate logistic analyses were used to evaluate the relationships between variables and endpoint. Results The levels of mGPS and LCS in the death group were significantly higher than those in the survival group (P < 0.05). The areas under the ROC curve of the mGPS and LCS for predicting death were 0.695 (95%CI: 0.567~0.823) and 0.736 (95%CI: 0.616~0.856), respectively. Multivariate analysis demonstrated that both LCS, LVEF and serum direct bilirubin were independent predictors of all-cause death, excluding mGPS. Conclusions Compared with mGPS, LCS is independently associated with short-term outcomes in patients with acute heart failure. LCS was a clinically promising and feasible prognostic scoring system for patients with acute heart failure.
Adapting to Adversity: Effects of COVID-19 on Parenting in Chile

The pandemic outbreak in March 2020 and its associated sanitary regulations and restrictions triggered an abrupt and significant change for society in general and for families’ organization in particular. In Chile, the Santiago Metropolitan District was under a strict lockdown that involved the closure of the entire educational system. From a systemic-family stress perspective, the impact of these changes might have consequences not only for each individual family member, but for the parental dynamic and, consequently, for children’s well-being. This paper presents the results of a follow-up study showing changes in self-reported parental depression and the perceived home organization of mothers and fathers assessed at three different moments: before the pandemic, at the initial outbreak, and after 1 month of strict lockdown. Relevant moderators were explored using linear mixed models to understand the within-subject changes in mothers’ and fathers’ self-reports across the different assessment times. Financial strain, personality traits of self-criticism and dependency, previous parent–child quality interaction, recent major stressful events, and number of children are highlighted as relevant factors that moderate changes in home chaos and parental mental health perception. Significant risks and protective factors are described for fathers and mothers. The use of pre-pandemic measures as baseline levels enabled the identification of personal and family characteristics that were related to better outcomes. The results help increase our understanding of the sanitary regulations’ impacts on the family system and identify vulnerability indicators that should be considered.
Proteomic Changes of Osteoclast Differentiation in Rheumatoid and Psoriatic Arthritis Reveal Functional Differences

Background Osteoclasts play a crucial role in the maintenance, repair, and remodeling of bones of the adult vertebral skeleton due to their bone resorption capability. Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are associated with increased activity of osteoclasts. Objectives Our study aimed to investigate the dynamic proteomic changes during osteoclast differentiation in healthy donors, in RA, and PsA. Methods Blood samples of healthy donors, RA, and PsA patients were collected, and monocytes were isolated and differentiated into osteoclasts in vitro using macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor κB ligand (RANK-L). Mass spectrometry-based proteomics was used to analyze proteins from cell lysates. The expression changes were analyzed with Gene Set Enrichment Analysis (GSEA). Results The analysis of the proteomic changes revealed that during the differentiation of the human osteoclasts, expression of the proteins involved in metabolic activity, secretory function, and cell polarity is increased; by contrast, signaling pathways involved in the immune functions are downregulated. Interestingly, the differences between cells of healthy donors and RA/PsA patients are most pronounced after the final steps of differentiation to osteoclasts. In addition, both in RA and PsA the differentiation is characterized by decreased metabolic activity, associated with various immune pathway activities; furthermore by accelerated cytokine production in RA. Conclusions Our results shed light on the characteristic proteomic changes during human osteoclast differentiation and expression differences in RA and PsA, which reveal important pathophysiological insights in both diseases.