Miracle-dz/UniFAR-FTUs huggingface dataset:
FAP Beige Adipogenesis in Volumetric Muscle Loss

Background Volumetric muscle loss (VML) often leads to chronic muscle weakness, impaired limb function, and even permanent disability. Recent studies suggest muscle residential fibro/adipogenic progenitors (FAPs) can adopt novel beige fat differentiation promoting muscle regeneration. The goal of this study is to define the role of FAP beige adipogenesis in muscle regeneration after VML in a mouse model.Methods Three months old male C57BL/6J mice, PDGFRα-GFP reporter mice, UCP-1 reporter mice, PDGFRα-CREERT/DTA inducible FAP depletion mice and NSG immune-deficient mice were used in this study. Volumetric muscle loss (VML) was created on tibialis anterior (TA) muscle with a punch. To induce FAP beige adipogenesis, Amibegron, a beta 3 adrenergic receptor (B3AR) agonist was administered to mice with I.P. injection. In a separate group, murine and human beige adipogenic FAPs was transplanted to mouse muscle after VML. Limb function was measured with gait analysis at 2 and 6 weeks after VML. Muscle histology and FAP gene expression analysis was also conducted at 2 and 6 weeks after VML.Results After VML, we observed robust proliferation of FAPs in PDGFRα-GFP reporter mice. PDGFRα-CREERT/DTA mice inducible FAP depletion mice showed reduced muscle regeneration after FAPs are depleted, suggesting a positive role of FAP in muscle regeneration after VML. Both Amibegron treatment and beige FAP transplantation significantly improved muscle regeneration and limb function after VML.Conclusion Stimulating FAP beige adipogenesis with B3AR agonists or transplantation of beige adipogenic FAPs could serve as new strategies in treating VML.
Prevalence and clinical significance of the triticeal cartilage

Objectives: The triticeal cartilage can be misidentified as an atheromatous plaque in the common carotid artery in radiological images. It is very important to correctly define these two structures and distinguish from each other. The aim of this study, therefore, was to investigate the shape, length, width and the anatomical position of the triticeal cartilage to prevent the interpretation of its presence as an atheromaous plaque or any other pathology located in the neck. Methods: This study was performed retrospectively on 200 CT images of adult patients (age≥20 years; 128 males, 72 females). The shape, size and localization of triticeal cartilage were examined and its prevalence was determined. Results: Triticeal cartilage was not present in 63 cases. It was present unilaterally in 42 cases and bilaterally in 95. The cartilage was located at the C4 level most frequently. The triticeal cartilage was identified under 7 types as circle, double circle, oval, hook, ring, triangle and rod. Circle type was the most common. There was a statistically significant difference for the presence of ring type cartilage between males and females (p<0.05). Although the mean cartilage length and width were higher in males than females, this difference was not statistically significant (p>0.05). Conclusion: The presence of the triticeal cartilage should be considered in the diagnosis of atheroma in carotid arteries. In order to distinguish the triticeal cartilage from other surrounding structures, the shape, level and size of the cartilage must be known.
Solitaire AB thrombectomy system: immediate results in 17 acute limb ischemia patients

Background Solitaire AB stent was approved for mechanical thrombectomy for acute cerebral infarction. Objectives To present our initial experience regarding the efficacy and safety of mechanical thrombectomy using the Solitaire AB device for the treatment of acute limb ischemia (ALI). Patients and methods 17 consecutive patients presenting with acute limb ischemia underwent endovascular therapy using the Solitaire AB device. Immediate angiographic results and early clinical outcomes are presented. Results Technical success was achieved in 15 patients (88.2%). Recanalization of more than IIb on the TILI scale was achieved for 15 patients. Mean times of thrombectomy attempts were 3 times.41.2%(n = 7) had excellent results. 41.2%(n = 7) patients had good results. 2 had fair results, and 1 patient had a poor result. 30days amputation rate was 6%(n = 1). There was no death case.
Dephenolization Using Complexation Extraction Method for Treating Waste AlkalineLiquor from an Oil Refinery

This paper relates to an experimental study for removing phenol from strong alkaline liquor discharged from an oil refinery using complexation extraction with tributyl phosphate(TBP)/kerosene solution as the solvent and NaOH solution to regenerate the extraction solution.Optimum operation condition is determined in terms of concentrations of extraction/reverse extraction solvents,pH and temperature.
Effectiveness of grape seed extract-based intracanal dressings against Enterococcus Faecalis and its influence on dentin microhardness and bond strength of filling material

The aim of this study was to evaluate the effectiveness of grape seed extract (GSE)based intracanal dressings against Enterococcus faecalis (E. faecalis) and its influence on dentin microhardness and bond strength of the filling material. The root canals of 126 human teeth were distributed into three test groups: antimicrobial activity (60 teeth), dentin microhardness (30 teeth) and bond strength (36 teeth). In all three groups, specimens were subdivided into six groups, according to intracanal dressing protocols: G1 – distilled water (DW); G2 – 2% chlorhexidine gel (CHX); G3 – calcium hydroxide (Ca[OH]2)+DW; G4 – GSE+DW; G5 – Ca(OH)2+CHX; G6 – GSE+CHX. The counting of colony-forming units (CFUs), the Vickers microhardness tester and the push-out test were performed to evaluate the antimicrobial activity, dentin microhardness and bond strength, respectively. Specific statistical analysis was performed for each evaluation (α=5%). The greatest bacterial reduction was observed in G5 (Ca[OH]2+CHX) and G6 (GSE+CHX) (p<0.05). There was no statistically significant difference among groups in the dentin microhardness evaluation (p<0.05). The highest bond strength in the immediate evaluation was observed in G4 (GSE+DW) and G6 (GSE+CHX), whereas the highest bond strength after 12 months of storage was observed in G2 (CHX), G3 (Ca[OH]2+DW), G4 (GSE+DW), and G6 (GSE+CHX) (p<0.05). After the storage period, bond strength was increased in G2 (CHX) and G3 (Ca[OH]2+DW), and remained unchanged in G4 (GSE+DW) and G6 (GSE+CHX) (p<0.05). GSE-based intracanal dressings have antimicrobial potential against E. faecalis, have no influence in dentin microhardness and preserve the high bond strength of filling materials for root dentin over time.
Synthesis of spiro-fused heterocyclic scaffolds through multicomponent reactions involving isatin

Isatin has been utilized in many heterocyclic preparations and considered as an important building block in organic synthesis. There is a wide range of multi-component reactions that include isatin in the synthesis of heterocyclic compounds. This review highlights the advances in the use of isatin as starting material in the synthesis of various organic compounds and drugs during the period from 2012 to 2015.
Potential antitumoral 3,4-dihydropyrimidin-2-(1H)-ones: synthesis, in vitro biological evaluation and QSAR studies

The search for novel anticancer agents with higher selectivity and lower toxicity remains a priority. This work aimed to design more potent and selective anticancer molecules among the class of 3,4-dihydropyrimidin-2-(1H)-ones. Thus, a series of molecules was synthesized through the Biginelli reaction and their in vitro antiproliferative activity was evaluated in different human cell lines. Then, a quantitative structure–activity relationship (QSAR) analysis was performed using Bayesian regularized artificial neural networks to model the relationships between in silico molecular descriptors and the observed antiproliferative activity of molecules across the tested cell lines. Interestingly, among the compounds prepared, the molecules containing chloro atoms in their structure demonstrated a relevant potency and a selective antiproliferative activity against a novel hepatic cancer cell line (HepaRG) without exhibiting noticeable cytotoxicity in normal dermal cells (NHDF). However, in prostatic (LNCaP), colon (Caco-2) and breast (T47D and MCF-7) cancer cell lines generally the compounds did not exhibit relevant cytoxicity. A statistically valid QSAR model was obtained (internal validation Q2 = 0.663, RMSECV = 0.071, 10-fold cross-validation procedure, and external validation Rpred2 = 0.740, RMSE = 0.077), which allowed the analysis of the involved relationships between molecular descriptors and the reliable prediction of the antiproliferative activity for hypothetical related compounds in the studied cell lines. Moreover, flow cytometry analysis showed that in HepaRG and MCF-7 cell lines, compound 16 did not decrease cell viability but, interestingly, led to an accumulation of cells in the G0/G1 phase of the cell cycle. Therefore, chlorinated 3,4-dihydropyrimidin-2-(1H)-ones may be considered promising compounds for further optimization as new antitumor agents.
Aggression and Studding Art

Aggressive behavior is one of the most common types of behavioral problems in almost all societies, so a pervasive field of research is used to work with that. This study tested the hypothesis that if art studding is associated with a decrease in aggression. Aggressive behavior was compared between art and industrial science groups. The study was a casualcomparative one and sixty university students selected with Purposive sampling and consideration of matching method in two groups. Aggression questionnaire (Buss & Perry, 1992) was used to assess aggression. Results in relation to investigated components namely verbal aggression, anger, hostel and aggression total score among art students and industrial science groups showed significant difference (p < .05) and this difference is that industrial science students report higher anger and aggression. But there was no significant difference in physical aggression between two groups (p ˃ .05). Mean of physical aggression scores in both groups were low and it could be considered as the worthless of physical aggression in university population. Studding art is found with less level of aggression and this may consider as an important implicit effect of art that could be expand in different areas and level of education.
Metodologia de Estimação de Estados de Redes de Distribuição com Penetração de Energia Fotovoltaica

The present work proposes the association of a state estimator with the technique for generating scenarios known as k-means, with the objective of evaluating the impact of the photovoltaic distributed generation in the problem of state estimation of active distribution networks. The method known as E-OPF of literature, which is based on a optimal power flow, is used in the state estimator, aiming at including in a efficient manner the uncertainties inherent to the photovoltaic generation. Monte Carlo Simulation is used to compare and validate the results obtained from the application of the proposed approach to a test system of literature comprising three photovoltaic plants. Resumo: O presente trabalho propõe a associação de um estimador de estados com a técnica de geração de cenários denominada k-means, com o objetivo de avaliar o impacto da geração distribúıda fotovoltaica no problema de estimação de redes de distribuição ativas. O método denominado E-OPF da literatura, baseado em fluxo de potência ótimo, é utilizado no estimador de estados, a fim de incluir de forma eficiente as incertezas inerentes à geração fotovoltaica. Simulação de Monte Carlo é utilizada para comparação e validação dos resultados, a partir da aplicação da metodologia proposta a um sistema teste da literatura envolvendo três usinas fotovoltaicas.
GLP-1R Activation Ameliorate Novel-object Recognition Function via Hippocampal AMPK/NF-κB Signaling Pathway in Neuropathic Pain Mice

Background: Growing evidences indicate that neuropathic pain is frequently accompanied with cognitive impairments, which aggravate the decrease in the quality of life of chronic pain patients. Furthermore, it has been shown that the activation of Glucagon-like-peptide-1receptor (GLP-1R) improved memory deficit in multiple diseases such as Alzheimer’s disease (AD), stroke and so on. However, whether activating GLP-1R could improve memory impairment induced by neuropathic pain and the mechanism by which this improvement would occur remain unclear. Methods: The spared nerve injury (SNI) model was established as a kind of neuropathic pain. And novel-object recognition memory (hippocampus-dependent memory) was tested by the novel object recognition test (NORT). The expression levels of GLP-1,GLP-1R,adenosine monophosphate-activated protein kinase (AMPK),p-AMPKThr172, nuclear factor κ B p65 (NF-κB p65), interleukin-1β p17(IL-1β p17),and the synaptic associated proteins were tested in the murine hippocampus with memory deficits caused by neuropathic pain. Then, exenatide acetate (Ex-4, a GLP-1R agonist), exendin(9-39)(Ex(9-39),a GLP-1R antagonist) and Compound C dihydrochloride ( CC, an AMPK inhibitor) were used to test the effects of activating GLP-1R in mice with neuropathic pain.Results: First, we uncovered that neuropathic pain could inhibit GLP-1/GLP-R axis, disturb inflammatory signaling pathway, increase the expression of IL-1β and downregulate the synaptic associated proteins (postsynaptic density protein 95(PSD95) and Arc). Subsequently, we reported that Ex-4 treatment could improve recognition memory impairment and increase the ratio of p-AMPKThr172/AMPK, decrease the expression of NF-κB p65 and IL-1β p17, upregulate the levels of PSD95 and Arc. Moreover, we uncovered that Ex(9-39) and CC treatment could abrogate the neuroprotection of Ex-4 in mice with memory impairment induced by neuropathic pain.Conclusions: The results indicated that the activation of GLP-1R could improve recognition memory impairment caused by neuropathic pain via activating AMPK signaling pathway, then, which could inhibit NF-κB activating and its downstream IL-1β expression, upregulate the levels of PSD95 and Arc proteins.
The Effect of a Six-week Core Stability Exercises on Balance, Strength, and Endurance in Female Students With Trunk Defects

Purpose: Core stability is the ability of the lumbopelvic-hip complex to prevent spinal instability and return to equilibrium after a perturbation. The special physical condition in students and especially the female ones-makes them prone to Trunk Defects (TDs); thus, it makes them prone to numerous injuries, like problems in balance. The present study aimed to examine the effect of Core Stability Exercises (CSEs) on static and dynamic balance, strength, and endurance among female students with TDs. Methods: This was a quasi-experimental study with a pretest-posttest design. The study samples were 30 female high-school students with TDs (Mean±SD age: 15.63±0.49 y, height: 1.60±0.04 m, & weight: 55.96±6.08 kg). All the subjects were placed in the same group. The Star Excursion Balance Test (SEBT) was used to evaluate the dynamic balance; One-Legged Stance Test (OLST) was employed to evaluate the static balance; the McGill test was applied to evaluate trunk endurance; a dynamometer was used to assess the trunk muscle strength, and tuck-jump screening test was implemented to determine students with TDs. These tests were employed at pretest and posttest phases. The research subjects followed CSEs for 6 weeks, 3 sessions per week, and approximately 45 minutes per session, supervised by the researcher. The Dependent Samples t-test at the significance level of P=0.05 was used for data analysis. Results: The present study results indicated a significant difference in strength, muscular endurance, as well as static and dynamic balance in the study subjects after the exercise program (P=0.001). Conclusion: According to the data, 6 weeks of CSEs could provide a solid foundation for the transfer of forces between the limbs. This is achieved by enhancing the strength and endurance of the core muscles of the body; accordingly, it leads to improved static and dynamic balance in female students with trunk control defect by reducing postural fluctuations. However, further extensive studies with larger sample sizes are required for providing more accurate conclusions.
Fe-Ni Nanoparticles: A Multiscale First-Principles Study to Predict Geometry, Structure, and Catalytic Activity

Nanoparticles of iron and nickel are promising candidates as nanosized soft magnetic materials and as catalysts for carbon nanotube synthesis and CO methanation, among others. To understand geometry- and size-dependent properties of these nanoparticles, phase diagram of Fe/Ni alloy nanoparticles was calculated by density functional theory and cluster expansion method. Ground state convex is presented for face-centered cubic (FCC), body-centered cubic (BCC), and icosahedral (ICO) particles. Previous experimental observations were explained by using multiscale model for particles with realistic size (diameter ≥2 nm). At size 1.5 nm, geometry changes from BCC at low X(Ni) to icosahedral at high X(Ni). FCC is stabilized over icosahedral geometry by increasing number of atoms from 561 to 923. In large FCC particles, there is enrichment of Fe atoms from core to shell beneath surface, while surface and core are enriched by Ni atoms. Catalytic enhancement effect in CO methanation was found to be due to Ni incorpo.
Institutional Investors and Corporate Environmental Innovation

This paper addresses whether institutional investors drive the innovation direction of corporates toward environmentally friendly technologies. Using environmental patents filed by Chinese publicly-listed firms in the manufacturing and public utility sectors during the 2003-2010 period, we seek to quantify the relationship between shareholding ratios of institutional investors and corporate environmental innovation. Some novel findings are obtained. Firstly, institutional investors lead to a higher ratio of environmental patents in total patents for corporates in the pollution-intensive sectors than those in the non-pollution-intensive sectors. Secondly, institutional investors exert the roles of financial support and corporate governance in pursuit of monitoring corporate’s long-term innovation. Lastly, institutional investors could experience gains in a rise in corporate market value from accumulative environmental innovation.
Gas chromatographic determination of propamocarb in agricultural commodities

A simple and efficient gas chromatographic (GC) method is described for quantitative determination of propamocarb in agricultural commodities. Propamocarb is extracted into acetone-water (or acidified solvent for dry products) and then cleaned up by extraction with diethyl ether. The analyte is extracted from the aqueous fraction under basic conditions with diethyl ether and then analyzed by GC with nitrogen-phosphorus detection. The minimum detection limit is 0.01 μg/g in original samples (signal-to-noise ratio > 5). Recovery of propamocarb spiked at 0.1 μg/g into various samples is >75%, except for lettuce (41%).
Preparation and evaluation of nano-crystalline titania as sorbent for 99Mo/99mTc generator

ABSTRACT In the presented work, nano-crystalline titania (TiO2) was synthesized and evaluated as a novel chromatographic sorbent for the preparation of the medical 99Mo/99mTc generator. TiO2 was synthesized by dissolving TiCl4.6H2O with isopropyl alcohol to form a semisolid mass that was extensively dried and washed. The physicochemical parameters and surface area of the synthesized nano-crystalline TiO2 were evaluated. TiO2 was packed as a chromatographic column to study the sorption of 99Mo-polymolybdate (VI) anionic solution by dynamic equilibrium. The maximum sorption capacity of 99Mo was ~141±2mg Mo/g TiO2, thereby confirming its suitability for using low specific activity 99Mo for the preparation of 99Mo/99mTc generator. The elution performance of the prepared 99Mo/99mTc generator based on Ti-99Mo was evaluated. It showed high radiochemical purity (≥ 97% TcO4−), high radionuclidic purity (≥ 99.99%99mTc) and high chemical purity; all of these specifications show the suitability for use in nuclear medicine applications.
Optimization of Wireless Power Transfer Configuration for High Efficiency Achievement

This paper discusses the efficiency improvement of a wireless power transfer system based on parameters design optimization. The wireless power transfer system is designed to operate at higher frequencies in order to reduce the component sizing as well as power density improvement. Configuration of the wireless power transfer system, i.e., transmitter and receiver coil are designed based on proper resonance frequency. The principle of the parameters design optimization is based on the single transmitter – multiple receiver coil configuration which reduces the system complexity and magnetic resonant method implementation which amplify the energy transferred between the coils. Simulation using ANSYS Maxwell and ANSYS Simplorer software shows the system efficiency is at the peak at the resonance frequency of 13.5571 MHz with a total power of 18 W delivered at a distance of 5 mm. Furthermore, the efficiency of AC – DC converter and high frequency DC – AC converter considered for power conversions are 99.81% and 99.51% respectively. Therefore, the maximum power transfer efficiency of the considered wireless power transfer system configuration is determined through this study.
Deploying data mining techniques to gain deeper insight into Nigerian customers' financial activities

Presently, Nigerian banks issue account statements in a tabular flat form. These statements mainly show basic logs of credit and debit transactions. They do not offer a deeper insight into the pure nature of transactions. Moreover, they lack rich mine-able data, and rather contain basic data tables that do not provide enough insights into customers' monthly/weekly/yearly expenses and earnings. In today’s fast-paced digital world, where information processing methods are rapidly changing, customers need not just a basic table of transactions but deeper analysis and detail report of their finances. This paper aims at identifying and addressing these problems by deploying data mining techniques and practices in building an application that helps customers gain a deeper insight and understanding of their spending and earnings over a particular period. Some of the techniques used are classification, statistical analysis, visualization, report generation and summarization. Keywords: Data mining, API, Anomaly Detection, GTBank, CBN, Bank statements, Nigeria
Mango fruit softening response to postharvest heat treatment

Mango fruit cv. 'Namdokmai' at the mature-green stage were heat-treated by dipping in 50°C or 55°C water for 5 min and stored at 25°C with 90-95% relative humidity. Fruit dipped in ambient water served as control. Softening slowed down in response to heat treatment. The effect of the two heat treatments did not considerably differ. Concomitant with softening, the heat-treated fruits exhibited reduced pectin methylesterase (PME) and polygalacturonase (PG) activities in both peel and pulp tissues. Heat treatment at 55°C generally resulted to lower PME and PG activity than at 50°C. These results indicate that heat inhibition of ripening-associated softening is due to inhibition of pectin-degrading enzymes.