Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessing the Quality of Preparation for Posthospital Care from the Patient's Perspective: The Care Transitions Measure

Background:Evidence that both quality and patient safety are jeopardized for patients undergoing transitions across care settings continues to expand. Performance measurement is one potential strategy towards improving the quality of transitional care. A valid and reliable self-report measure of the quality of care transitions is needed that is both consistent with the concept of patient-centeredness and useful for the purpose of performance measurement and quality improvement. Objective:We sought to develop and test a self-report measure of the quality of care transitions that captures the patient's perspective and has demonstrated utility for quality improvement. Subjects:Patients aged 18 years and older discharged from one of the 3 hospitals of a vertically integrated health system were included. Research Design:Cross-sectional assessment of factor structure, dimensionality, and construct validity. Results:The Care Transitions Measure (CTM), a 15-item uni-dimensional measure of the quality of preparation for care transitions, was found to have high internal consistency, reliability, and reflect 4 focus group-derived content domains. The measure was shown to discriminate between patients discharged from the hospital who did and did not have a subsequent emergency department visit or rehospitalization for their index condition. CTM scores were significantly different between health care facilities known to vary in level of system integration. Conclusions:The CTM not only provides meaningful, patient-centered insight into the quality of care transitions, but because of the association between CTM scores and undesirable utilization outcomes, it also provides information that may be useful to clinicians, hospital administrators, quality improvement entities, and third party payers.
Construction of Chiral Tetraorganosilicons by Tandem Desymmetrization of Silacyclobutanes/Intermolecular Dehydrogenative Silylation.

We report a method to construct chiral tetraorganosilicons by tandem silacyclobutane (SCB) desymmetrization-dehydrogenative silylations. A wide array of dibenzosiloles with stereogenic quaternary silicon centers were obtained in good yields and enantioselectivities up to 93 % ee. Chiral TMS-segphos was found to be a superior ligand in terms of reactivity and enantioselectivity.
Contact Lenses: A Delivery Device for Stem Cells to Treat Corneal Blindness

&NA; Worldwide, 45 million people are blind. Corneal blindness is a major cause of visual loss, estimated to affect 10 million. For the most difficult to treat patients, including those with a disease called limbal stem cell deficiency, a donor corneal graft is not a viable option; thus, patients are treated with specialized stem cell grafts, which fail in a significant proportion (30 to 50%) of subjects. This unacceptable failure rate means there is a pressing need to develop minimally invasive, long-lasting, cost-effective therapies to improve patient quality of life and lessen the economic burden. Restoring vision in patients with severe corneal disease is the main focus of our research program; however, to achieve our goals and deliver the best quality stem cell therapy, we must first understand the basic biology of these cells, including their residence, the factors that support their long-term existence, markers to identify and isolate them, and carriers that facilitate expansion, delivery, and protection during engraftment. We recently achieved some of these goals through the discovery of stem cell markers and the development of a novel and innovative contact lens–based cell transfer technique that has been successfully trialed on patients with corneal blindness. Although several popular methodologies are currently available to nurture and transfer stem cells to the patients’ ocular surface, contact lenses provide many advantages that will be discussed in this review article. The job for clinician-researchers will be to map precisely how these cells contribute to restoring ocular health and whether improvements in the quality of cells and the cell delivery system can be developed to reduce disease burden.
Steroid hormone-inducible expression of the GLT-1 subtype of high-affinity l-glutamate transporter in human embryonic kidney cells.

The cDNA encoding the predominant rat brain high-affinity l-glutamate transporter GLT-1 was isolated and subcloned into the pIND expression vector for the establishment of steroid hormone inducible expression in vitro using the ecdysone-inducible mammalian expression system. Steroid hormone-inducible expression was demonstrable in a stable cell line designated HEK/GLT-1. Treatment of HEK/GLT-1 cells with 10 microM ponasterone A for 24 hincreased the maximum velocity (V(max)) of Na(+)-dependent l-glutamate uptake by greater than 10-fold, as compared with the uninduced cells. Equivalent levels of l-glutamate transport capacity were observed in the uninduced GLT-1 cell line and the host cell line indicating that the expression of GLT-1 was tightly regulated. To confirm that the increased l-glutamate uptake observed in HEK/GLT-1 cells following induction was attributable to the expression of GLT-1, rather than the up-regulation of the endogenously expressed EAAT3 subtype present in the host cells, we evaluated the effects of the selective GLT-1 inhibitors dihydrokainate (DHK) and kainate. Both DHK and kainate produced concentration-dependent inhibition of the l-glutamate uptake into HEK/GLT-1 cells, and the estimated IC(50) values were consistent with those described for the cloned GLT-1. These results demonstrate that the expression of GLT-1 can be tightly regulated in vitro using the ecdysone system.
Health-related quality of life as a predictor of mortality and hospitalization: the Dialysis Outcomes and Practice Patterns Study (DOPPS).

BACKGROUND We investigated whether indicators of health-related quality of life (HRQOL) may predict the risk of death and hospitalization among hemodialysis patients treated in seven countries, taking into account serum albumin concentration and several other risk factors for death and hospitalization. We also compared HRQOL measures with serum albumin regarding their power to predict outcomes. METHODS We analyzed data from the Dialysis Outcomes and Practice Patterns Study (DOPPS), an international, prospective, observational study of randomly selected hemodialysis patients in the United States (148 facilities), five European countries (101 facilities), and Japan (65 facilities). The total sample size was composed of 17,236 patients. Using the Kidney Disease Quality of Life Short Form (KDQOL-SFTM), we determined scores for three components of HRQOL: (1) physical component summary (PCS), (2) mental component summary (MCS), and (3) kidney disease component summary (KDCS). Complete responses on HRQOL measures were obtained from 10,030 patients. Cox models were used to assess associations between HRQOL and the risk of death and hospitalization, adjusted for multiple sociodemographic variables, comorbidities, and laboratory factors. RESULTS For patients in the lowest quintile of PCS, the adjusted risk (RR) of death was 93% higher (RR = 1.93, P < 0.001) and the risk of hospitalization was 56% higher (RR = 1.56, P < 0.001) than it was for patients in the highest quintile level. The adjusted relative risk values of mortality per 10-point lower HRQOL score were 1.13 for MCS, 1.25 for PCS, and 1.11 for KDCS. The corresponding adjusted values for RR for first hospitalization were 1.06 for MCS, 1.15 for PCS, and 1.07 for KDCS. Each RR differed significantly from 1 (P < 0.001). For 1 g/dL lower serum albumin concentration, the RR of death adjusted for PCS, MCS, and KDCS and the other covariates was 1.17 (P < 0.01). Albumin was not significantly associated with hospitalization (RR = 1.03, P> 0.5). CONCLUSION Lower scores for the three major components of HRQOL were strongly associated with higher risk of death and hospitalization in hemodialysis patients, independent of a series of demographic and comorbid factors. A 10-point lower PCS score was associated with higher elevation in the adjusted mortality risk, as was a 1 g/dL lower serum albumin level. More research is needed to assess whether interventions to improve quality of life lower these risks among hemodialysis patients.
Mental number line, number line estimation, and mathematical achievement : Their interrelations in grades 5 and 6

As indicated by the distance effect and the spatial-numerical association of response codes (SNARC) effect, natural numbers are mentally represented on a number line, Purportedly, this number line underlies children's number sense, which supports the acquisition of more advanced mathematical competencies, In 3 studies with a total of 429 fifth and sixth graders, the authors compared the influences of each child's distance effect, SNARC effect, conceptual knowledge about decimal fractions, and numerical intelligence on mathematical school achievement. Additionally, they tested using decimal fractions whether number line estimation competence mediates the influence of the internal number line. In all, the results, found with path models, revealed that domain-specific conceptual knowledge, numerical intelligence, and number line estimation each were good predictors of achievement, while distance and SNARC effects were virtually unrelated to all other variables. Individual differences in the use of the internal number line, as assessed by these 2 effects, seem to be of little importance when it comes to the acquisition of the content of 5th- and 6th-grade mathematics lessons. The results instead highlight the importance of conceptual understanding and estimation competence
Information seeking and use behaviour of economists and business analysts

Introduction. The aim of this paper is to deal with the information seeking and use problem in a professional context and understand how activity can influence practices, by taking as examples, the research undertaken by economic analysts. We analyse the relationship between the situational approach, described by Cheuk, the work environment complexity (with social, technological and personal aspects), and the information seeking and use strategies, which relied on Ellis and Wilson's model, with Bates's comments. Method. We interviewed eight economists, using a questionnaire and the SICIA (Situation, Complexity and Information Activity) method. The SICAI method is a qualitative approach, which underlines the relationship between situations, professional contexts and strategies. Both methods allow better understanding of how investment analysts find out what they need for their job. We can clarify their information sources and practices of information seeking, which are very particular because of their activities. We complete our analysis by interviewing analysts from financial institutions. Analysis. A qualitative mode of analysis was used to interpret the interviewees' comments, within the research framework adopted. Results. We find similarity in information seeking and use strategies used by these two groups and environmental levels meet in most situations. But some differences can be also found, explained by the activity frameworks and goals. Conclusion. This study demonstrates that the activity and also the professional context (here the financial context) can directly influence practices.
Timing of Blastocyst Expansion Affects Spatial Messenger RNA Expression Patterns of Genes in Bovine Blastocysts Produced In Vitro1

Abstract Blastocyst formation and expansion are dependent on the differentiation and function of a proper transport of nutrients through the trophectoderm (TE) enclosing the inner cell mass (ICM). Coincident with compaction and cavitation, glucose becomes the preferred energy substrate of the early embryo. These hallmarks in early development require well-orchestrated gene expression patterns specifically with regard to timing and localization. The present study investigated the relative abundance (RA) of gene transcripts in the two lineages of in vitro-produced expanded bovine blastocysts in relation to timing of development, i.e., blastocyst expansion and localization of specific mRNAs. Expanded blastocysts from either Day 7 or Day 8 or isolated ICMs derived thereof were analyzed with the aid of a semiquantitative reverse transcriptase-polymerase chain reaction assay for gene transcripts, which are thought to play a pivotal role in blastocyst expansion, i.e., Na/K-ATPase α1 subunit (Na/K), E-cadherin (E-cad), zonula occludens protein-1 (ZO-1), desmocollin II (Dc II), plakophilin (Plako), trophoblastic function (interferon τ [IFτ]), and glucose transport (glucose transporter-1, -3, -4 [Glut-1, -3, -4]). Total cell number, ICM cell number, or ICM/total cells ratio were similar in Day 7 and Day 8 expanded blastocysts. Significant differences were determined in the RA for Na/K, E-cad, Dc II, Plako, and ZO-1 transcripts between TE cells of expanded blastocysts derived from either Day 7 or Day 8. The RA of Dc II, Glut-1, and Glut-4 was significantly decreased in the ICM compared with the TE at Day 7. Similarly, the RA of Na/K, Dc II, Glut-1, and Glut-4 at Day 8 of development was significantly decreased in the ICM compared with the TE. Interestingly, no differences were observed when comparing ICMs originating from blastocysts expanded at either Day 7 or Day 8. Plako and IFτ transcripts were not detected in isolated ICMs, indicating that expression of these mRNAs is restricted to the TE. In contrast, similar expression patterns within the ICM and TE were determined for Na/K, E-cad, ZO-1, and Glut-3 mRNA. Dc II, Glut-1, and Glut-4 were more abundant in the TE than in ICM. Results show that expression of developmentally important genes is related to the two cell lineages in the early embryo and emphasize the critical role of a well controlled spatial gene expression pattern for regular preimplantation development.
A hybrid mesh-tree peer-to-peer overlay structure for layered video streaming

Due to complicated implementation of IP multicast, application layer multicast has attracted the attention of researchers. Tree overlay has some challenges such as resiliency problems caused by peer churns and also network resources may not be efficiently used. Mesh overlay doesn't have such problems, but has a high delivery latency and overhead caused by pull mechanism. Using a hybrid mesh/tree overlay offers push pull approach and leads to use the advantages of both overlays simultaneously. Also in p2p networks a significant problem is heterogeneity of peers. In this paper we propose a hybrid mesh/tree overlay that by means of streaming layered coded video, addresses these challenges. This overlay poses other critical design challenges such as latency and resiliency issues that stable nodes in a distributed algorithm form a tree in order to accelerate media streaming.
Long-Term Cell Survival and Hemodynamic Improvements after Neonatal Cardiomyocyte and Satellite Cell Transplantation into Healed Myocardial Cryoinfarcted Lesions in Rats

Cell engraftment is a new strategy for the repair of ischemic myocardial lesions. The hemodynamic effectiveness of this strategy, however, is not completely elucidated yet. In a rat model of cryothermia-induced myocardial dysfunction, we investigated whether syngeneic transplantation of neonatal cardiomyocytes or satellite cells is able to improve left ventricular performance. Myocardial infarction was induced in female Lewis rats by a standardized cryolesion to the obtuse margin of the left ventricle. After 4 weeks, 5 × 106 genetically male neonatal cardiomyocytes (n= 16) or satellite cells (n = 16) were engrafted into the myocardial scar. Sham-transplanted animals (n = 15) received injections with cell-free medium. Sham-operated animals (n = 15) served as controls. Left ventricular performance was analyzed 4 months after cell engraftment. Chimerism after this sex-mismatched transplantation was evaluated by detection of PCR-amplified DNA of the Y chromosome. The average heart weight of the infarcted animals significantly exceeded that of controls (p < 0.05). In sham-transplanted animals, mean aortic pressure, left ventricular systolic pressure, aortic flow (indicator of cardiac output), and left ventricular systolic reserve were significantly lower (p < 0.05) compared with sham-operated controls. This was associated with deterioration of ventricular diastolic function (maximal negative dP/dt, time constants of isovolumic relaxation; p < 0.05). Transplantation of satellite cells was found more effective than transplantation of neonatal cardiomyocytes, resulting in i) normalization of mean aortic pressure compared with sham-operated controls, and ii) significantly improved left ventricular systolic pressure and aortic flow (p < 0.05) compared with sham-transplanted animals. Left ventricular systolic reserve and diastolic function, however, were improved by neither satellite cell nor neonatal cardiomyocyte transplantation. Analysis of male genomic DNA revealed 3.98 ± 2.70 ng in hearts after neonatal cardiomyocyte engraftment and 6.16 ± 4.05 ng in hearts after satellite cell engraftment, representing approximately 103 viable engrafted cells per heart. Our study demonstrates i) long-term survival of both neonatal cardiomyocytes and satellite cells after transplantation into cryoinfarcted rat hearts, ii) slight superiority of satellite cells over neonatal cardiomyocytes in improving global left ventricular pump performance, and iii) no effect of both transplant procedures on diastolic dysfunction.
Organizing Open Digital Innovation: Evidence from Hackathons

In this research, I study a novel open digital innovation phenomenon called hackathons. Hackathon, literally meaning a sprint of coding, is an open source programming competition for problem solving. Hackathons lead to self-organizing of a new group at the onset of a challenge, which questions a previously dominant imagery in organization studies that organization already exists as a static entity. The Information Systems (IS) scholars have recently started studying new organizational arrangements in terms of open innovation but we have paid less attention in emerging hackathon organizing. By taking a close look at this distinct environment for innovation, the study can provide a coherent account on the generative mechanism for open innovation and its relationship with the characteristics of digital technology. This research contributes to theory by looking at what transpires in this new organizing context for open digital innovation.
Characterization and stability of hydroxyapatite coatings prepared by an electrodeposition and alkaline-treatment process.

Hydroxyapatite (HA) coatings on titanium alloy substrates were prepared by an alkaline treatment of electrodeposited precursors. The structure, residual stress, and bond strength of the coatings were investigated. Test results showed that the coatings processed in this study exhibited fairly low tensile residual stress, high crystallinity, and were free of an amorphous phase. The bond strength of the coatings increased with the decrease of current density in the range of 0.2-15 mA/cm(2), and reached 14 MPa at 0.2 mA/cm(2). Evaluation of the coatings was performed together with the evaluation of the plasma-sprayed HA coatings immersed in distilled water. It was revealed that the dissolution and bond strength degradation of the coatings were much lower than those of the plasma-sprayed HA coatings.
Microwave dielectric spectroscopy: An emerging analyzing technique for biological investigations at the cellular level

This paper presents a current status of microwave dielectric spectroscopy at the cellular level for biological investigations. The convergence of microfluidic and microwave microtechnologies enables indeed the development of an innovative observation technique of the living at the micro-scale. The non-invasive and label free detection of living or dead cells in their culture medium without any contact, the possible identification of the bio-elements and the real time monitoring ability of the technique constitute major features, which are suitable for early diseases diagnostic, preliminary and personalized drugs evaluation, toward a better patient healthcare.
Evaluation of chemical and gene/protein entity recognition systems at BioCreative V.5: the CEMP and GPRO patents tracks

We acknowledge the OpenMinted (654021) and the ELIXIREXCELERATE (676559) H2020 projects, and the Encomienda MINETAD-CNIO as part of the Plan for the Advancement of Language Technology for funding. The Spanish National Bioinformatics Institute (INB) unit at the Spanish National Cancer Research Centre (CNIO) is a member of the INB, PRB2-ISCIII and is supported by grant PT13/0001/0030, of the PE I+D+i 2013-2016, funded by ISCIII and ERDF.
Eliciting Conversation in Robot Vehicle Interactions

Dialog between drivers and speech-based robot vehicle interfaces can be used as an instrument to find out what drivers might be concerned, confused or curious about in driving simulator studies. Eliciting ongoing conversation with drivers about topics that go beyond navigation, control of entertainment systems, or other traditional driving related tasks is important to getting drivers to engage with the activity in an open-ended fashion. In a structured improvisational Wizard of Oz study that took place in a highly immersive driving simulator, we engaged participant drivers (N=6) in an autonomous driving course where the vehicle spoke to drivers using computer-generated natural language speech. First, using microanalyses of drivers’ responses to the car’s utterances, we identify a set of topics that are expected and treated as appropriate by the participants in our study. Second, we identify a set of topics and conversational strategies that are treated as inappropriate. Third, we show that it is just these unexpected, inappropriate utterances that eventually increase users’ trust into the system, make them more at ease, and raise the system’s acceptability as a communication partner.
Microwave class-E power amplifiers

This paper reviews circuit architectures and demonstrated class-E power amplifiers in the UHF and microwave frequency range. Scaling class-E soft-switching operation to high frequencies presents a number of challenges, particularly in the control of parasitic reactances of the device and the circuit. Different approaches have been taken, from using parasitics of lumped elements to provide the correct fundamental and harmonic impedances in the UHF range, to transmission-line implementations at frequencies above 10GHz.
Challenging Marr’s theory of the cerebellum

Introduction to motor learning theory There have been successive attempts to understand the relationships between the structure, function, and dynamics in neuronal circuits (Arbib et al., 1998) in the hope of explaining behavior. At different times these attempts have been based on the available experimental data and conceptual tools and have been synthesized into various theories and models. One of the most famous is Marr’s theory of the cerebellum, the so-called motor learning theory (MLT; Marr, 1969), which was developed in the late 1960s and has since then dominated the view of how the cerebellum might function. To be fair we must say that the MLT was extended by Albus two years later (Albus, 1971) and then further developed by Ito in the subsequent decades (Ito, 1972; Ito, 1984; Ito, 1993, 2006, 2008). Thus, it is appropriate to consider it as the Marr–Albus–Ito theory. The MLT was based purely on statistical connectivity rules, so that, unavoidably, it did not take into account the myriad biological parameters that are now considered critical to guarantee cerebellar network functioning. Therefore, over the years Marr’s theory has been repeatedly challenged by new experimental findings and concepts. In this chapter, I analyze the major aspects of the MLT, how it has been challenged experimentally, and how it has contributed to our understanding of the structure–function relationship of the cerebellar circuit and the adaptive behaviors that are dependent on the cerebellum.