Miracle-dz/UniFAR-FTUs huggingface dataset:
Polymorphonuclear Microdomains of Human Formyl-Met-Leu-Phe within Lipid Raft Complexes for Leukotriene B4 and Selective Localization of Recognition

Neutrophilic polymorphonuclear leukocytes contain glycosphingolipid- and cholesterol-enriched lipid raft microdomains within the plasma membrane. Although there is evidence that lipid rafts function as signaling platforms for CXCR chemokine receptors, their role in recognition systems for other chemotaxins such as leukotriene B4 (LTB4) and fMLP is unknown. To address this question, human neutrophils were extracted with 1% Brij-58 and fractionated on sucrose gradients. B leukotriene receptor-1 (BLT-1), the primary LTB4 receptor, partitioned to low density fractions, coisolating with the lipid raft marker, ﬂotillin-1. By contrast, formyl peptide receptor (FPR), the primary fMLP receptor, partitioned to high density fractions, coisolating with a non-raft marker, Cdc42. This pattern was preserved after the cells were stimulated with LTB4 or fMLP. Fluorescence resonance energy transfer (FRET) was performed to conﬁrm the proximity of BLT-1 and FPR with these markers. FRET was detected between BLT1 and ﬂotillin-1 but not Cdc42, whereas FRET was detected between FPR and Cdc42, but not ﬂotillin-1. Pretreating neutrophils with methyl- (cid:1) -cyclodextrin, a lipid raft-disrupting agent, suppressed intracellular Ca 2 (cid:2) mobilization and ERK1/2 phosphorylation in response to LTB4 but had no effect on either of these responses to fMLP. We conclude that BLT-1 is physically located within lipid raft microdomains of human neutrophils and that disrupting lipid raft integrity suppresses LTB4-induced
A Mesofractal Model of Interstellar Cloudiness

The interstellar medium (ISM), serving as a background for the propagation of cosmic rays (CRs) and other information carriers, has a complex ragged structure. Being chaotically scattered over interstellar space, together with the magnetic field perturbations frozen in them, CRs are connected with each other by a network of magnetic field lines creating long-range correlations of a power-law type, similar to those observed in the spatial distribution of galaxies. These lines solving interstellar transfer problems require the choice of an ISM model, adequately and concisely representing their statistical properties. This article discusses one such model, the Uchaikin–Zolotarev model: a four-parameter approximation of the power spectrum spatial correlations, derived from the generalized Ornstein–Zernike equation. The numerical analysis confirmed that this approximation satisfactorily agrees with the numerical data obtained in the quasi-linear model of plasma turbulence.
A Study on the Effects of Intrinsic Motivation, Extrinsic Motivation and Pre-knowledge of Office Workers on the Hybrid Start-up Intention

This study identified the influence of employees' hybrid start-up intention (intention to start a business while maintaining a job) on the employees' self-determination motivation (intrinsic motivation, extrinsic motivation) and prior knowledge through the Model of Goal-directed Behavior (MGB). We used a PLS-SEM called SmartPLS 3.0 for 126 valid samples collected by judgement extraction for office workers throughout June 13, 2020 to July 3, 2020, and empirically evaluated the measurement model (internal consistency reliability, convergent and discriminant validity) and the structural model (multicollinearity, determination coefficient, effect size, predictive relevance, etc.). Only the intrinsic motivation for realizing the hybrid start-up goal of office workers had a significant impact on the hybrid start-up attitude and subjective norms, and the prior knowledge of hybrid start-up had a significant impact on the hybrid start-up desire and the hybrid start-up intention. In order to induce hybrid start-ups for workers with unstable employment, we need systems and programs that can inspire employees with intrinsic motivation and knowledge about hybrid start-up, so follow-up researches are necessary to analyze about government systems and consulting support that can promote hybrid start-up.
Examining the Process and Efects of Engaging Patients and Family in Health Service Evaluation: Results from a One-Year Prospective Intervention Study

: Research on program evaluation in the context of patient and family engagement is highly limited. Collaborative approaches to evaluation (CAE), with their emphasis on evaluators working in partnership with program community members, align well with patient- and family-centred care philosophy and hold great promise in leveraging desired outcomes. In this prospective intervention case study, we tracked a one-year collaborative initiative to engage health care providers, patients, and family members in improvement-oriented needs assessment activities. T e f ndings illuminate the lived experiences of health-care staf, patients, and family members with the CAE process. We conclude with implications for ongoing research and practice.
e s Obsolete Models in Introductory and Organic Chemistry

In this analysis, we discuss two models in chemistry that we consider obsolete: hybrid atomic orbitals (HAO) and valence-shell electron-pair repulsion (VSEPR). We present a thorough discussion, with examples in hypervalent and main-group molecules, of problems when and where HAO are used. Common misconceptions in the use of HAO are highlighted, particularly in relation to purported lone pairs. VSEPR is then shown to be problematic; the links among HAO, VSEPR and resonance structures present further anomalies.
6 Inhibits Effector T Cell Activation in The Purinergic G Protein-Coupled Receptor

We show that the P2Y 6 receptor, a purinergic G protein-coupled receptor with a high afﬁnity for the nucleotide uridine di-phosphate, is an important endogenous inhibitor of T cell function in allergic pulmonary inﬂammation. Mice conditionally deﬁcient in P2Y 6 receptors [ p2ry6 (ﬂox/ﬂox);cre/+ mice] exhibited severe airway and tissue pathology relative to P2Y 6 -sufﬁcient [ p2ry6 (ﬂox/ﬂox)] littermates (+/+ mice) when treated intranasally with an extract of the dust mite Dermatophagoides farinae ( Df ). P2Y 6 receptors were inducibly expressed by lung, lymph node, and splenic CD4 + and CD8 + T cells of Df -treated +/+ mice. Df restimulated P2Y 6 -deﬁcient lymph node cells produced higher levels of Th1 and Th2 cytokines, and polyclonally stimulated P2Y 6 deﬁcient CD4 + T cells proliferated faster than comparably stimulated P2Y 6 -sufﬁcient cells. The absence of P2Y 6 receptors on CD4 + cells, but not APCs, was sufﬁcient to amplify cytokine generation. Thus, P2Y 6 receptors protect the lung against exuberant allergen-induced pulmonary inﬂammation by inhibiting the activation of effector T cells. The Journal of Immunology , 2011, 187: 1486–1495.
Assessing How Understory Plant and Pollinator Interactions are Affected by Differing Canopy Phenologies

Advancements in springtime phenologies of plants and their pollinators have been widely observed within the northern hemisphere due to climate change. The observed advancements have led to concern over potential mismatching occurring between plant-pollinator interactions. The effect of forest canopies on understory phenological interactions has scarcely been investigated. We studied the effect of differing canopy closure parameters on understory phenological interactions within Plymbridge woods, Devon, UK, over a 6-month study period. The temporal overlap between canopy, understory flower and pollinators were investigated using Pianka overlap indices. Canopy phenology was modelled using NLSTIMEDIST package of R, giving three canopy parameters, canopy r (maximum rate of canopy closure), canopy c (temporal concentration) and canopy t (canopy closure duration). All temporal overlap values were as expected within the woodland, suggesting no mismatching has occurred within the woodland to date. Supporting previous literature, suggesting plants and their pollinators are shifting phenologies at similar rates. Canopy r was seen to have a significant positive relationship with the overlap between canopy and understory flowers, suggesting as canopy closure rate increased, the temporal overlap between canopy and flowers also increased. However, Canopy c contradicted this with a negative relationship with the overlap between canopy and understory flowers. The discrepancies seen between these
Predicting Overburden-Induced Failure Height of Large Mining Face in Shallow Coal Seam Based on Half-Plane Theory

Research on the overburden-induced failure height in large mining faces is important for solving the problems of sand rupture and water permeability when mining in shallow depth. In order to solve the safety and high-efficiency mining problems, this study used the 7 m-high face #52306 of the Daliuta mine as the object of research for theoretical analysis and field measurements. The results show that the traditional empirical formula is not suitable for predicting overburden on three zones of the large mining face in shallow depth. We use elastic half-plane theory to establish a mechanical model to calculate overburden-induced stress and analyze the law of transmission of abutment pressure in the overburden. We then use maximum shear stress theory to develop a method to predict the height of the overburden in the “three zones” of the mining face based on the law of change in the shear stress. According to the characteristic whereby shear stress at the rear of the working face increases first and then decreases, the area where the shear stress was greater than zero was defined as the zone of water conduction-induced fracture, the area where the shear stress increased was identified as the zone of collapse, and the area where the shear stress decreased was defined as the fracture zone. A comparison of the theoretically calculated values with empirically measured data showed that the relative error was controlled to within 6%, verifying the reliability of the proposed method. The results here can provide useful information for the efficient and environmentally friendly mining of shallow coal seams.
Spatial and environmental constraints on natural forest regeneration in the degraded landscape of Hong Kong

3 Tropical forests are the main reservoirs for global biodiversity and climate control. As 4 secondary forests are now more widespread than primary forests, understanding their 5 functioning and role in the biosphere is increasingly important. This includes understanding 6 how they achieve stability, how they accumulate species and build biodiversity and how they 7 cycle nutrients and carbon. This study investigates how we can restore tropical secondary 8 forests to resemble high biomass, highly biodiverse and stable ecosystems seen today only in 9 primary, undisturbed forests. The study used historic aerial photographs and recent high- 10 resolution satellite images from 1945 to 2014 to map forest patches with five age categories, 11 from 14-years to over 70-years, in Hong Kong´s degraded tropical landscape. A forest 12 inventory comprising 28 quadrats provided a rare opportunity to relate patterns of species 13 composition at different stages during the succession with topographic and soil characteristics. 14 The topographic variables accounted for 15 % of the variance in species abundance, and age 15 of forest stands explained 29 %. Species richness rapidly increased after the first 15 years, but 16 was lower in old-growth, than in medium age forest. This is attributed to the inability of late- successional species to disperse into the 'new, young' forests as the natural dispersal agents 18 (birds, mammals) have been lost. Light-loving pioneers which are unable to tolerate the shade 19 of older forests, cannot regenerate in their own shade, therefore species diversity declines after a few decades. For ecosystem restoration in tropical secondary forests, introduction of late- 21 successional species is necessary to assist natural succession, given the absence of native fauna, 22 seed dispersal agents, and the surrounding altered environment. We also show that remote 23 sensing can play a pivotal role in understanding the recovery and functioning of secondary forest regeneration as its role in the biosphere is increasingly important.
The magnetoactive electret

A magnet which adheres to every surface, not only those of ferromagnetic materials, has hitherto been the domain of science fiction. Now for the first time such a novel device exists. The fusion of a permanently magnetized magnetoactive polymer containing hard magnetic particles and an electret enhanced with ferroelectric particles has resulted in the development of a new smart device—the magnetoactive electret. Magnetoactive electrets can be made to exhibit the usual magnetic properties of permanent magnetism together with the electrostatic properties of electrets. This results in simultaneous magnetoadhesion and electroadhesion forces from the same elastomeric element. The biasing field, needed to avoid discontinuities concerned with transition through the zero point in operating curves, is normally provided by means of either a magnetic or an electric field. This novel technology provides both bias options in a single device.
Design of efficient single target real-time beam tracking system

This paper builds a system for real-time tracking of a single target Radio Frequency (RF) signal source, in which the transmitter uses a low-cost HackRF One software radio transceiver platform, and the receiving antenna array uses two monopole antennas to form a 1×2 receiving array. The receiver uses Xilinx 7-Series development board Zedboard and AD9361 RF transceiver to build a wireless receiving platform to process the received signal. In this RF beam tracking system, it needs to perform Direction of Arrival (DOA) estimation on the calibrated signal, the DOA algorithm plays a crucial role in the accuracy of beam pointing and system running time, the MUSIC algorithm takes some time to conduct spectrum peak search, so the Root-Music algorithm is used here to avoid the spectrum peak search problem. To enable the Root-MUSIC algorithm to be better executed on this two-element receiving platform, this work simplifies the entire calculation process, requiring only a small amount of calculation and running time to complete the DOA estimation step, which effectively save FPGA processing time and computing resources. It provides a guarantee for the real-time performance of the system.
Time-domain modelling and performance research of millimeter-wave all-digital phase-locked loop

In this paper, a modified time-domain model of millimeter-wave all-digital phase-locked loop (ADPLL) is implemented. In order to reflect the true behaviour of ADPLL, a quantified output digitally controlled-oscillator (DCO) with time domain jitter is proposed. In this ADPLL time-domain model, the DCO model can only output discrete frequency points to imitate the quantization effect of true DCO, and the overlap of different level tuning band is added into this model to imitate the true situation. In addition, the DCO time domain jitter and wander are also added into this model by using the Box-Muller method. Finally, a period estimation method is used to calculate the phase power spectrum density of the output signal, and then the phase noise is obtained through subsequent processing.
Dual-mass silicon micro-gyroscope

Dual-mass silicon micro-machined gyroscopes can effectively eliminate the effect of common mode disturbance caused by axial acceleration,etc. A new dual-mass double-linear vibratory silicon micro-mechanical gyroscope was designed by using structure-decoupled method. Based on the structure and the principle of operation,the driving and sensing modals of this new dual-mass gyro were analyzed in theory by using the simplified dynamic equations. By using the finite element software Ansys,the driving and sensing modals of the gyroscope were numerical simulated. The simulation results show that the structure design can realize the full decoupling of the driving mode and sensing mode. So the simulation results validate the correctness of the design. The frequencies in drive mode and sense modals were also obtained by the simulation. The paper also briefly introduces the gyro's fabrication technology . The circuit was used to test a fabricated gyro sample's driving and sensing frequencies. Because of the processing errors,the frequencies are 1.6% deviation between test results and simulation results. Finally,the rotary table was used to test the gyro's scale factor. The dual-mass silicon micro-gyro's scale factor is 2.518 mV/((°) ? s-1) .
Local climate change indications: Historical trends, multi-model projections and implications in Bilate Catchment, Southern Ethiopia

Climate change is a major factor affecting hydrologic processes, water resources and agricultural productions in a catchment. This study aimed to evaluate the historical trends, future climate changes, characteristics of heat waves, dry and wet months in Bilate catchment, southern Ethiopia. The Mann-Kendal, Theil-Sen estimator were employed to analyse the trends and magnitude of trends of historical temperature and rainfall. Ensemble mean of regional climate models (RCMs) was employed for the future climate projections of this (2021-2050), mid (2051-2070), and end (2081-2100) centuries relative to baseline (1981-2010). Results revealed that the change in temperature under RCP4.5 and RCP8.5 showed an increase in the three future periods. Under the scenarios, the monthly maximum temperature is projected to increase in the range of 0.1 to 2.4 °C and 0.1 to 4.2 °C, respectively. Likewise, the minimum temperature is in the range of 0.1 to 1.9°C and 0.3 to 3.5 °C. Under the scenarios, seasonal rainfall is projected to increase in the range of 124 to 3,009.9 mm and 52.5 to 1111.0 mm; while decreases are from -19.4 to -1679.3 and -243.3 to -2,444.7 mm, respectively. Besides, dry months and heat waves are expected to increase. The combined effect of a reduction in rainfall, increase in heat waves and dry months will likely impact on the people whose livelihood depend on rain-fed subsistence agriculture in the catchment. Water and crop yield reduction are the major implications in this century. These findings raise awareness about the impacts of climate change in the community and regional authorities to endorse development policies.
A comparison of public-private partnership development of previously used land in the UK

In the UK public-private partnerships are currently the only method of developing previously used land. How these partnerships are formed and how they work can differ considerably however, depending on the approach taken by the partners. Through interviews with the key actors, including the developers, local authorities and interest groups, the paper explores three case studies of urban regeneration projects in the south-west of England: Harbourside Bristol; Gloucester Quays; and Firepool, Taunton. The paper is designed to identify the processes, procedures, contracts and relationships that exist and enabled the regeneration process to occur. At the time of selecting the case studies there were over 600 regeneration projects taking place in the UK. These were predominantly focused to the south and south west of the country. Many of the large-scale regeneration schemes such as London Docklands have been studied extensively and it was noted that there has been little research on the impact of development on small-medium towns and cities in the UK, and this is a knowledge gap that the paper has been designed to address. The background to each of the selected case study, shows why they are of interest. The first case study is Bristol Harbourside, a city centre location that had been awaiting redevelopment for a number of decades. The land owners and City Council created the Harbourside Sponsors’ Group in 1993 to identify the appropriate developers for the site and bring funding to the city. Developers Crest Nicholson were chosen to develop the area in 1997, and had to go through several planning applications and met with considerable public opposition before the final masterplan was approved in 2001 and was completed in 2015. The second case study is Gloucester Quays, a small to medium city location. Gloucestershire County Council, along with the now defunct Regional Authority founded a regeneration company in 2004 to bring investment to the city and this included the £200m development of the Quays by Peel Holdings and British Waterways (the landowners). Firepool, Taunton is a property led development of the former livestock market and railway yards, close to the mainline railway station. The local authority set up the Taunton Vision in 2002 to develop the consultation process for the redevelopment of the town. In addition to the development the County Council were awarded funding for a new distributor road adjacent to the western section of the development to ease traffic movements within the city centre. The similarities and differences between the partnerships and how the developments proceeded was examined to identify the strengths and weaknesses of each approach, with an institutional map developed to provide a greater level of understanding and will help identify the best practices for future public-private partnership developments. This paper forms part of the PARCOUR project is funded by the FAPESP-ESRC-NOW joint call ‘Sustainable Urban Development’.
Semi­discrete, semi­linear SPDEs

Consider an inﬁnite system of interacting Itˆo diﬀusions, started at a nonnegative deterministic bounded initial proﬁle. We study local and global features of the solution under standard regularity assumptions on the nonlinearity σ . We will show that, locally in time, the solution behaves as a collection of independent diﬀusions. We prove also that the k th moment Lyapunov exponent is frequently of sharp order k 2 , in contrast to the continuous-space stochastic heat equation whose k th moment Lyapunov exponent can be of sharp order k 3 . When the underlying walk is transient and the noise level is suﬃciently low, we prove also that the solution is a.s. uniformly dissipative provided that the initial proﬁle is in ℓ 1 ( Z d ).
A simple model considering spiking probability during extracellular axon stimulation

The spiking probability of an electrically stimulated axon as a function of stimulus amplitude increases in a sigmoidal dependency from 0 to 1. However, most computer simulation studies for neuroprosthetic applications calculate thresholds for neural targets with a deterministic model and by reducing the sigmoid curve to a step function, they miss an important information about the control signal, namely how the spiking efficiency increases with stimulus intensity. Here, this spiking efficiency is taken into account in a compartment model of the Hodgkin Huxley type where a noise current is added in every compartment with an active membrane. A key parameter of the model is a common factor knoise which defines the ion current fluctuations across the cell membrane for every compartment by its maximum sodium ion conductance. In the standard model Gaussian signals are changed every 2.5 μs as a compromise of accuracy and computational costs. Additionally, a formula for other noise transmission times is presented and numerically tested. Spiking probability as a function of stimulus intensity can be approximated by the cumulative distribution function of the normal distribution with RS = σ/μ. Relative spread RS, introduced by Verveen, is a measure for the spread (normalized by the threshold intensity μ), that decreases inversely with axon diameter. Dynamic range, a related measure used in neuroprosthetic studies, defines the intensity range between 10% and 90% spiking probability. We show that (i) the dynamic range normalized by threshold is 2.56 times RS, (ii) RS increases with electrode—axon distance and (iii) we present knoise values for myelinated and unmyelinated axon models in agreement with recoded RS data. The presented method is applicable for other membrane models and can be extended to whole neurons that are described by multi-compartment models.