Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of the CXC12-CXCR4 Axis and CXCL16 in Inflammatory Bowel Disease

󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏 Numerous studies of colitis in IBD (inflammatory bowel diseases) patients and in animal models have demonstrated that both inflammatory cytokines and chemokines are up-regulated in settings of active inflammation. Blockade or absence of various cytokines and chemokines attenuates the disease in murine models of IBD. Therefore, identifying cytokines and chemokines involved in intestinal inflammation provide promising targets for the development of new drugs in the treatment of IBD. In general, chemokines have been implicated in many fundamental immune processes including lymphoid organogenesis, immune cell differentiation, development and positioning. Many chemokines are markedly increased in intestinal tissue from patients with IBD. In this study, we focused on the role of CXCL12-CXCR4 and CXCL16. CXCL12-CXCR4 axis plays a crucial role in the pathophysiology of IBD, especially UC, while SR-PSOX/CXCL16 plays a significant role in the pathophysiology of CD. Our present data suggest new insights into the etiology of IBD and we hope that the manipulation of these chemokines may have therapeutic (Intest Res (cid:44)(cid:70)(cid:90)(cid:1) (cid:56)(cid:80)(cid:83)(cid:69)(cid:84)(cid:27)(cid:1) Inflammatory Bowel Diseases; Chemokine; CXCL12-CXCR4
Think Phased Implementation for Successful Data Warehousing

Abstract Industry watchers have noted that the success rate of data warehouse (DW) implementations has not been exemplary. It is believed that over 50 percent of DW implementations fail to achieve their stated goals. However, there are things that executives can do to improve their chance of success. Like other forms of organizational change, the DW implementation process follows a three-phased pattern of evolution. Clear recognition by management of the phased logic of DW implementation, and the differing role of critical implementation factors (CIFs) in each of the phases, can enhance the probability of success. This article presents a framework that helps executives visualize how CIFs can be customized and embedded in each phase of the DW implementation process.
Molecular epidemiology of Staphylococcus epidermidis in neonatal intensive care units

Late‐onset sepsis (LOS) in preterm neonates is increasingly reported to be associated with gut‐colonizing Staphylococcus epidermidis. We aimed to describe the molecular epidemiology of S. epidermidis colonizing the gut of neonates hospitalized in two neonatal intensive care units. S. epidermidis from rectal swabs were typed by multilocus variable‐number tandem‐repeat analysis (MLVA), randomly chosen isolates of predominant MLVA types additionally by multilocus sequence typing. Antimicrobial susceptibility, the presence of icaA, IS256, arginine catabolic mobile element (ACME), agr type, and SCCmec type were determined. Of 276 neonates (38.4%), 106 were colonized with S. epidermidis, yielding a total of 139 isolates (62 in one unit and 77 in another unit). Of the 55 MLVA types identified, the five predominant detected in both units corresponded to sequence type (ST) 2, ST5, and ST59 or its single locus variant ST81 and formed three major MLVA clonal complexes accounting for 74.8% of all isolates. Overall, the prevalence of mecA, icaA, IS256, and ACME was 91.4%, 28.1%, 64%, and 77%, respectively. Of the mecA‐positive isolates (n = 127), 43.9% carried SCCmec type IV. Of eight episodes of LOS, four were caused by ST2 and two by ST5. Preventing gut colonization with nosocomial epidemic S. epidermidis in hospitalized neonates could contribute to the prevention of LOS.
IFI16 reduced expression is correlated with unfavorable outcome in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. Its clinical course is typically indolent; however, based on a series of pathobiological, clinical, genetic, and phenotypic parameters, patient survival varies from less than 5 to more than 20 years. In this paper, we show for the first time that the expression of the interferon‐inducible DNA sensor IFI16, a member of the PYHIN protein family involved in proliferation inhibition and apoptosis regulation, is associated with the clinical outcome in CLL. We studied 99 CLLs cases by immunohistochemistry and 10 CLLs cases by gene expression profiling. We found quite variable degrees of IFI16 expression among CLLs cases. Noteworthy, we observed that a reduced IFI16 expression was associated with a very poor survival, but only in cases with ZAP70/CD38 expression. Furthermore, we found that IFI16 expression was associated with a specific gene expression signature. As IFI16 can be easily detected by immunohistochemistry or flow cytometry, it may become a part of phenotypic screening in CLL patients if its prognostic role is confirmed in independent series.
Outcomes of total joint arthroplasties in adults with post-polio syndrome: results from a tertiary neuro-orthopaedic center

BackgroundPatients with paralytic poliomyelitis or post-polio syndrome can develop osteoarthritis with time. Most clinicians are hesitant to offer joint arthroplasty as an option because long-term outcomes are unknown. The purpose of this study was to determine the feasibility of performing total joint arthroplasties in arthritic hips and knees in adult patients with post-polio syndrome and to evaluate outcomes. MethodsAll adult patients with post-polio syndrome who had lower extremity joint arthroplasty for osteoarthritis at our institution were reviewed. A detailed physical examination, manual muscle testing, joint range of motion, spine evaluation, gait evaluation and orthotic assessment were performed on all patients. Appropriate scoring systems were used to evaluate the outcomes, including the Harris Hip Scoring System (HHSS) and the Knee Society Scores (KSS). ResultsSeventeen symptomatic patients with osteoarthritis underwent 19 joint arthroplasties. Mean age at surgery was 66.5 years. All patients experienced notable pain relief after surgery. The mean KSS improved from 28 to 88 (10 cases) and the mean HHSS improved from 94 to 173 (nine cases). The functional ambulation level improved an average of one grade in all patients. No radiographic evidence of loosening or wear of the prosthesis was observed at final follow-up (mean 92 months; 26–180). ConclusionsTotal joint arthroplasty can be a safe and effective treatment for osteoarthritis in patients with post-polio syndrome with predictable resolution of pain, improved function and preservation of muscle strength.
−141C insertion/deletion polymorphism of the dopamine D2 receptor gene is associated with schizophrenia in Chinese Han population: Evidence from an ethnic group‐specific meta‐analysis

Accumulate evidence has implicated dopamine D2 receptor gene polymorphisms in the etiology of schizophrenia. A single nucleotide polymorphism, −141C insertion/deletion (Ins/Del) (rs1799732), in the promoter region of the dopamine D2 receptor gene has been linked to schizophrenia; however, the data are inconclusive. This study investigated whether the −141C polymorphism is associated with the risk of schizophrenia in different ethnic groups by performing a meta‐analysis. A total of 24 case–control studies examining the association between −141C Ins/Del polymorphism and schizophrenia were identified according to established inclusion criteria. Significant association was revealed between −141C Ins/Del polymorphism and schizophrenia risk in dominant genetic model (Ins/Ins + Ins/Del versus Del/Del) (odds ratio = 0.33, 95% confidence interval = 0.14–0.81, z = 2.41, P = 0.02) in Chinese Han but not in Caucasian, Japanese or India populations. Our results indicate that −141C Ins/Del polymorphism might be a susceptibility factor for schizophrenia in Chinese Han population.
Well-Done Literature Reviews: A Journal's Editor--in--Chief Perspective

As academics and researchers, we are taught to conduct and report on our research. One of the basic skills we learn is to conduct and write the literature review. Jennex (2009) discusses the value of good literature reviews as being the building and strengthening of a body of knowledge. Good research that is not basic research builds on that which was done before and uses previous research to ground current research in theory and as a lens for interpreting results. However, as the numbers of information systems (IS) journals grow—Lamp (2004) lists 861 IS journals with 735 still active (as of March 25, 2014)—the time and effort it takes to conduct a thorough and comprehensive literature review is growing. The result of increasing time to conduct and report on the literature review is that the quality of the literature review is declining. Of course, fueling the growth in IS journals is the increase in academics and researchers conducting and submitting research. The result of having more research articles being written is that there are more to review, creating a drain on limited reviewer resources. The data to support these statements comes
ANATOMICAL STUDY OF THE ABDOMINAL AORTA SACRAL RAMI OF THE OPOSSUM (Didelphis albiventris)

El objetivo de este estudio fue describir la anatomia de la aorta abdominal de la comadreja overa (Didelphis albiventris) enfatizando las arterias iliacas comunes, las arterias iliacas interna y externa y la arteria sacra mediana. Utilizamos 10 animales Didelphis albiventris del Departamento de Anatomia, Instituto de Biociencias - UNESP, Botucatu, Brasil. Despues de la laparotomia fueron examinadas la aorta y sus ramas terminales, disecadas bajo microscopio y fotografiadas. La aorta abdominal origino las arterias iliacas comunes derecha e izquierda, las cuales se dividen en las arterias iliacas externa e interna. La arteria sacra mediana se origino en el 30% de los casos de la arteria iliaca comun derecha, en el 30% de la arteria iliaca comun izquierda y en el 40% como una continuacion de la aorta abdominal
Validation of an XCT/fDOT System on Mice

In this paper we present systems for dual modality imaging, combining fluorescence-enhanced diffuse optical tomography and X-ray computed tomography. Fluorescence diffuse optical tomography is carried out in a cylindrical geometry, which ensures optimal sampling and a straight forward integration with the X-ray modality. Specific acquisition protocols and reconstruction software have been developed to this end. The X-ray computed tomography serves two purposes. First, it provides the anatomical information in the registered dual modality images. Second, it provides the actual shape and boundaries of the animal as a priori input to the fluorescence reconstruction algorithm. To evaluate the performance of the optical imaging system, experiments have been conducted on phantoms, mice with inserted fluorescing capillaries, and finally on mice bearing tumors, ex-vivo and in-vivo. Experiments on mice with capillaries inserted in different region of interest, allow estimating the detection limits of fluorophore concentrations. The fluorescence reconstructions are shown to be geometrically consistent with the X-ray images. Finally we demonstrate the capability of the bimodal system to localize real tumours in mice in-vivo. These results show that dual modality fluorescence-enhanced diffuse optical tomography and X-ray computed tomography imaging in cylindrical geometry has a high potential for small animal tumour evolution studies.
Antimicrobial use in companion animals and Good Stewardship Practice

THE growing threat of antimicrobial resistance (AMR) is focusing human and animal medicine on all aspects of how to improve antimicrobial drug use, so that we can not only try to preserve these ‘miracle drugs’, but also buy the time needed to develop new antimicrobials (AMs) and alternative approaches to the control of infections. In the 70-plus years since the development of antibiotics, we have largely taken their availability and efficacy for granted, but for many bacterial pathogens this is no longer the case. Much of the global focus on AMR in animals has been on reducing agricultural use as a way to mitigate AMR in zoonotic pathogens and commensals that can reach the human population. Only in recent years has antimicrobial use (AMU) in companion animals come under scrutiny, both as a source of emerging important resistance issues (such as meticillin-resistant Staphylococcus aureus [MRSA] and Staphylococcus pseudintermedius [MRSP]) and as a potential source for multidrug resistant (MDR) pathogens for people. Untreatable MDR infections are now being encountered in companion animals. To date, studies on AMU in primary care companion animal veterinary practice have been characterised by their small sample size and labour intensive nature. The study by Buckland and others (2016) summarised on p 489 in this issue of Veterinary Record , is a remarkable tour de force that quantifies AMU over a two-year period across 374 veterinary practices in the United Kingdom. It involved nearly 1,000,000 dogs and 600,000 cats. By far the most comprehensive study of its type, it demonstrates the power of mega-data that can be acquired through shared practice software, as well as the tenacity of the authors in sorting through the lack of standardisation in some electronic patient records. An estimated 1473 kg and 58 kg of AMU was found in dogs and cats, respectively. During …
Reimbursement for Screening Mammography—The Medicare Disparity: A Policy Perspective

Ripley’s stage sequential model is used to analyze the disparity in the Medicare reimbursement for screening mammography for older women in the United States. The article presents a historical review of the policy issue and suggests solutions to set the agenda for policy change. Problem identification, costs, and ethical and social issues are evaluated, and policy change is recommended.
Diagnosis, classification and treatment of mucopolysaccharidosis type I

Introduction: Mucopolysaccharidosis type I (MPS I) is a progressive lysosomal storage disease. Impaired degradation of glycosaminoglycans triggers complex pathophysiological cascades, leading to a heterogeneous multisystem disorder. Two treatment modalities are available: enzyme replacement therapy and hematopoietic stem cell transplantation. Despite these treatments, a significant residual disease burden is observed in most patients. Areas covered: This review provides an overview of the currently known pathophysiological mechanisms underlying disease manifestations in MPS I. Additionally, the clinical presentation of the wide phenotypic spectrum is discussed, as well as methods for the phenotypical classification of patients and available treatment options, with a special focus on the treatment of residual disease. Expert opinion: Residual disease is currently the most pressing issue in MPS I, often requiring multiple surgical interventions. Several strategies are being explored to decrease the residual disease burden including modifications to the current treatment regimens and new therapeutic approaches. Optimal management of disease manifestations requires international collaboration and a standardized follow-up to collect essential clinical data.
Protective Effects of Moderate Hypothermia after Neonatal Hypoxia-Ischemia: Short- and Long-Term Outcome

We have previously shown that mild hypothermia applied after hypoxia-ischemia in newborn piglets and rats reduces brain injury evaluated 3-7 d after the insult. The aim of the present study was to assess the neuroprotective efficacy of hypothermia with respect to short-(neuropathology) and long-term (neuropathology and sensorimotor function) outcome after hypoxiaischemia in 7-d-old rats. One hundred fourteen animals from 13 litters survived either 1 or 6 wk after a hypoxic-ischemic insult. The animals were randomized to either 1) normothermic recovery for the whole 1- or 6-wk period or 2) cooling to a rectal temperature of 32.0 °C for the first 6 h followed by normothermic recovery with the dam. Hypothermia offered a uniform protection of 27, 35, 28, and 25% in cerebral cortex, hippocampus, basal ganglia, and thalamus, respectively, in the 1-wk survivors (n = 32). The corresponding values for the 6-wk survivors(n = 61) were 22, 28, 37, and 35%. There was a significant correlation between sensorimotor performance and infarct volume (r = 0.66; p < 0.001). However, the sensorimotor function was not significantly improved by hypothermia if all animals were included, but in female pups the total functional score was higher in the hypothermia group(150 ± 35 versus 100 ± 34, p < 0.0007) which corresponded to a marked (51%) reduction of the neuropathology score in this subgroup. This is the first neonatal study to show a long-term histopathologic protection of the brain after posthypoxic hypothermia.
Gender-Related Heart Rate Differences in Human Neonates

The aim of the present study was to examine gender-related differences in heart rate of human neonates controlled for their behavior. Previous studies could not find any difference in male and female fetuses and newborns, although this gender-dependent difference clearly exists in children and adults. The heart rate of 99 newborns (47 girls and 52 boys) was measured with simultaneous video recording of their behavior. Results proved that alert newborns showed the same difference as adults: boys had a significantly lower baseline heart rate than girls. This suggests that heart rate is gender-dependent from birth onward.
The Safety of Penicillin V: Oral Penamecillin Use During Pregnancy The Importance and Limitation of Recall Bias

The purpose of the study was to check the human teratogenic potential of penicillin V: oral penamecillin treatment during pregnancy in the population‐based dataset of the Hungarian Case‐Control Surveillance of Congenital Abnormalities between 1980 and 1996. The pairs of cases with congenital abnormalities and their matched population controls without congenital abnormalities were evaluated, in addition the data of total population and of patient control groups as referents were compared with the data of congenital abnormality groups. In the three study groups there were 38,151 pregnant women who had newborn infants without any defects (population control group), 22,865 pregnant women who had newborns or fetuses with congenital abnormalities, and 812 mothers of informative offspring with Down syndrome (patient controls). In the population control group 2,246 (5.9%) pregnant mothers were treated with penamecillin, in the case group 1,597 (7.0%) pregnant women had penamecillin treatment while in the patient control group 63 (7.9%) mothers used penamecillin during pregnancy. The use of penamecillin treatments during pregnancy was higher in the total case (i.e., congenital abnormality) group, than in the total population control group. However, the highest use of oral penamecillin was found in the patient control group. The case‐matched population control pair analysis did not show a higher use of medically documented penamecillin during the second‐third months of pregnancy, i.e., in the critical period for most major congenital abnormalities. In addition, an association between medically documented penamecillin use during the second and third months of gestation and different congenital abnormality groups was not found when total population control group or patient control groups were used as referent. Thus, the reported higher use of penamecillin among the mothers of cases and patient controls can be explained mainly by recall bias. Thus, treatment with oral penamecillin during pregnancy did not indicate detectable teratogenic risk to the fetus.
Long‐term follow‐up of successful hepatitis C virus therapy: waning immune responses and disappearance of liver disease are consistent with cure

A sustained viral response (SVR) after interferon‐based therapy of chronic hepatitis C virus (HCV) infection is regarded to represent a cure. Previous studies have used different markers to clarify whether an SVR truly represents a cure, but no study has combined a clinical work‐up with highly sensitive HCV RNA detection, and the determination of immune responses.
Learn by doing

A voyeur was reported peer­ ing into the women’s showers at the Crandall Gymnasium locker room on Tuesday afternoon, ac­ cording to Public Safety. “I was is my bathing suit rins­ ing down before class and I thought I saw a person,” said Jill Beliveau, human development senior. “So, I stood there for a second watching. All of a sudden a man’s face appeared in the window. He saw me and jumped away. ” ITie incident occurred shortly at 12:08 p.m. , Beliveau said. “I was shocked and worried,” Beliveau said. “I was more con­ cerned with other people, but I did not want to make a scene. If I did that, I figured he would get awj^ for sure. ” Inere was no one else in the showers, but there were a lot of faculty and students changing clothes, Beliveau said. “I told (my instructor) and she called Public Safety immediate­ ly,” Beliveau said. “This happened last spring, too,” said Stacey Tiner, a Rec Sp>orts aqua aerobics instructor. Officer Richard Lara arrived at Crandall shortly after noon, but a search yielded no suspect, said Public Safety Investigator Mike Kennedy, According to Kennedy, the suspect is a white male in his early 20’s with brown hair. He was wearing a red shirt when last seen, Kennedy said. The suspect is not considered dangerous, he added. “This is something that hap­ pens on campus,” Kennedy said.
Epigenetic Mechanisms and the Mismatch Concept of the Developmental Origins of Health and Disease

There is now considerable evidence that elements of the heritable or familial component of disease susceptibility are transmitted by nongenomic means, and that environmental influences acting during early development shape disease risk in later life. The underlying mechanisms are thought to involve epigenetic modifications in nonimprinted genes induced by aspects of the developmental environment, which modify gene expression without altering DNA sequences. These changes result in life-long alterations in gene expression. Such nongenomic tuning of phenotype through developmental plasticity has adaptive value because it attempts to match an individual's responses to the environment predicted to be experienced. When the responses are mismatched, disease risk increases. An example of such mismatch is that arising either from inaccurate nutritional cues from the mother or placenta before birth, or from rapid environmental change through improved socioeconomic conditions, which contribute substantially to the increasing prevalence of type-2 diabetes, obesity, and cardiovascular disease. Recent evidence suggests that the effects can be transmitted to more than the immediately succeeding generation, through female and perhaps male lines. Future research into epigenetic processes may permit us to develop intervention strategies.
Systematic review with meta‐analysis: the risk of major gastrointestinal bleeding with non‐vitamin K antagonist oral anticoagulants

Gastrointestinal (GI) bleeding is a common complication among anticoagulated patients. Non‐vitamin K antagonist oral anticoagulants (NOACs) are associated with increased risk of GI (major and clinically relevant non‐major) bleeding. However, more information is needed regarding severe events.
A Fast Parametric Maximum Flow Algorithm and Applications

The classical maximum flow problem sometimes occurs in settings in which the arc capacities are not fixed but are functions of a single parameter, and the goal is to find the value of the parameter such that the corresponding maximum flow or minimum cut satisfies some side condition. Finding the desired parameter value requires solving a sequence of related maximum flow problems. In this paper it is shown that the recent maximum flow algorithm of Goldberg and Tarjan can be extended to solve an important class of such parametric maximum flow problems, at the cost of only a constant factor in its worst-case time bound. Faster algorithms for a variety of combinatorial optimization problems follow from the result.