Miracle-dz/UniFAR-FTUs huggingface dataset:
Is Mindful Parenting Associated With Adolescents’ Emotional Eating? The Mediating Role of Adolescents’ Self-Compassion and Body Shame

This study aimed to explore whether parents’ mindful parenting skills were associated with adolescents’ emotional eating through adolescents’ levels of self-compassion and body shame. The sample included 572 dyads composed of a mother or a father and his/her child (12–18 years old), with normal weight (BMI = 5–85th percentile) or with overweight/obesity with or without nutritional treatment (BMI ≥ 85th percentile) according to the WHO Child Growth Standards. Parents completed self-report measures of mindful parenting (Interpersonal Mindfulness in Parenting Scale), and adolescents completed measures of self-compassion (Self-Compassion Scale-Short Form), body shame (Experience of Shame Scale), and emotional eating (Dutch Eating Behavior Questionnaire). Two path models, one with the total score for mindful parenting and the other with its dimensions, were tested in AMOS. Mindful parenting, specifically the dimension of compassion for the child, was indirectly associated with emotional eating through adolescents’ self-compassion (point estimate = −0.27, p = 0.03, CI 95% [−0.61, −0.06]) and through self-compassion and body shame sequentially (point estimate = −0.19, p = 0.03, CI 95% [−0.37, −0.05]). The path model was invariant across weight groups but not across adolescents’ sex (the indirect effects were significant among girls only). This study provides a novel comprehensive model of how mindful parenting, especially the dimension of compassion for the child, can be associated with adolescents’ emotional eating behaviors by suggesting a potential sequence of mechanisms that may explain this association. This study suggests the beneficial effect of both mindful parenting and adolescents’ self-compassion skills for adolescent girls struggling with feelings of body shame and emotional eating behaviors.
Speech Understanding and Sound Localization with a New Nonimplantable Wearing Option for Baha

Objective To measure the audiological benefit of the Baha SoundArc, a recently introduced nonimplantable wearing option for bone conduction sound processor, and to compare it with the known softband wearing option in subjects with normal cochlear function and a purely conductive bilateral hearing loss. Methods Both ears of 15 normal hearing subjects were occluded for the time of the measurement, yielding an average unaided threshold of 49 dB HL (0.5 – 4 kHz). Soundfield thresholds, speech understanding in quiet and in noise, and sound localization were measured in unaided conditions and with 1 or 2 Baha 5 sound processors mounted on either a softband or a SoundArc device. Results Soundfield thresholds and speech reception thresholds were improved by 19.5 to 24.8 dB (p<.001), when compared to the unaided condition. Speech reception thresholds in noise were improved by 3.7 to 4.7 dB (p<.001). Using 2 sound processors rather than one improved speech understanding in noise for speech from the direction of the 2nd device and sound localization error by 23° to 28°. No statistically significant difference was found between the SoundArc and the softband wearing options in any of the tests. Conclusions Bone conduction sound processor mounted on a SoundArc or on a softband resulted in considerable improvements in hearing and speech understanding in subjects with a simulated, purely conductive, and bilateral hearing loss. No significant difference between the 2 wearing options was found. Using 2 sound processors improves sound localization and speech understanding in noise in certain spatial settings.
Who's Your DadA? d-Alanine Levels Regulate Bacterial Stiffness

A central question in mechanobiology is how cellular-scale structures are established and regulated. In bacteria, the cell envelope is essential for mechanical integrity, protecting against environmental stresses and bearing the load from high turgor pressures. ABSTRACT A central question in mechanobiology is how cellular-scale structures are established and regulated. In bacteria, the cell envelope is essential for mechanical integrity, protecting against environmental stresses and bearing the load from high turgor pressures. Trivedi et al. (mBio 9:e01340-18, 2018, https://doi.org/10.1128/mBio.01340-18) screened a Pseudomonas aeruginosa transposon library and identified genes that influence cell stiffness by measuring cell growth while cells were embedded in an agarose gel. Their findings provide a broad knowledge base for how biochemical pathways regulate cellular mechanical properties in this pathogen. Dozens of genes across diverse functional categories were implicated, suggesting that cellular mechanics is a systems-level emergent property. Furthermore, changes in d-alanine levels in a dadA (d-alanine dehydrogenase) mutant resulted in decreases in the expression of cell wall enzymes, cross-linking density, and cell stiffness. These insights into the biochemical and mechanical roles of dadA highlight the importance of systems-level investigations into the physical properties of cells.
Content validity of the developmental care scale for neonates with CHD

Abstract Purpose Neuroprotective developmental care is paramount for neonates with CHD. Although several developmental care scales exist, either they have not been psychometrically tested or were not designed for the needs of neonates with CHD. The purpose of this study is to describe item development and content validity testing of the developmental care scale for neonates with CHD, which measures five domains of the developmental care provided by bedside nurses to neonates in the cardiac ICU: sleep, pain and stress management, activities of daily living, family-centred care, and environment. Methods For this cross-sectional study, items were developed based on clinical expertise and the core measures for developmental care. In this study, seven experts provided content validity ratings of items for total scale and subscale fit and relevance. A content validity index was used to determine item retention. Item modifications and additions were based on expert feedback. Results Expert ratings provided evidence of content validity on 24 of 53 items within the five domains of developmental care. A total of 24 items were deleted, and five items with low content validity ratings were retained, because of conceptual importance, and revised. An additional 11 items were added based on expert qualitative feedback. Conclusions This study provided evidence of content validity of the developmental care scale for neonates with CHD by researchers and bedside nurses caring for these neonates. Further psychometric testing is warranted to provide evidence of internal consistency reliability, construct validity, and to identify variables that influence quality of the developmental care.
CrossSim: Exploiting Mutual Relationships to Detect Similar OSS Projects

Software development is a knowledge-intensive activity, which requires mastering several languages, frameworks, technology trends (among other aspects) under the pressure of ever-increasing arrays of external libraries and resources. Recommender systems are gaining high relevance in software engineering since they aim at providing developers with real-time recommendations, which can reduce the time spent on discovering and understanding reusable artifacts from software repositories, and thus inducing productivity and quality gains. In this paper, we focus on the problem of mining open source software repositories to identify similar projects, which can be evaluated and eventually reused by developers. To this end, CrossSim is proposed as a novel approach to model open source software projects and related artifacts and to compute similarities among them. An evaluation on a dataset containing 580 GitHub projects shows that CrossSim outperforms an existing technique, which has been proven to have a good performance in detecting similar GitHub repositories.
Identification modules of gastric cancer based on protein-protein interaction networks and gene expression data.

PURPOSE The tumorigenesis of gastric cancer is an intricate process which contains genetic and epigenetic changes of proto-oncogenes and cancer-suppressor genes. The purpose of this study was to identify novel modules for gastric cancer based on protein-protein interaction networks and gene expression data. METHODS Microarray data and corresponding annotated files of E-GEOD-15460 were downloaded from ArrayExpress database. All human protein-protein interactions were downloaded from STRING database. The fast depth-first assay was used to identify all maximal cliques of disease group and control group. Benjamini-Hochberg method was used to perform multiple corrections of p value. RESULTS 248 modules for the control group and 30 modules for the disease group were determined in this research, and 734 pairs of similar or same modules of these two groups were detected through calculating module correlation density. Protein-protein interaction (PPI) network was identified, which comprised of 7899 genes and 48469 interrelationship pairs of genes. Finally, 6 modules with remarkable difference were found to be closely related with gastric cancer. CONCLUSIONS Novel modules with significant difference and the related genes are useful biomarkers and therapeutic targets for gastric cancer.
The Role of Firm Size and Customer Orientation on Halal Transportation Adoption

The purpose of this paper is to propose an innovation adoption framework in the context of halal transportation. This paper provides a discussion on the development of halal transportation adoption framework using Technology-Organization-Environment (TOE) framework insight with literature. Currently, the issues on halal transportation adoption have still not been resolved even though several motivational factors have been identified to gain the attention from potential adopters. This paper further proposes innovation adoption factors for halal transportation. It consists of two internal organizational dimensions, namely: firm size and customer orientation. In addition, this paper also explains the roles that firm size and customer orientation can play on halal transportation adoption. Halal transportation adoption framework is important to halal logistics providers as it gives a significant input to the adoption of their services. Overall, this paper contributes to a newly-developed innovation adoption framework in the context of halal transportation.
Interventions to improve adherence to exercise therapy for falls prevention in community-dwelling older adults: systematic review and meta-analysis

BACKGROUND exercise therapy is highly recommended for falls prevention in older adults; however, poor exercise adherence may limit treatment effectiveness. OBJECTIVE to assess the effectiveness of interventions to improve exercise adherence for community-dwelling adults (aged over 65 years), at risk of falling. METHODS eight databases were searched to identify randomised/quasi-randomised trials. The Capability, Opportunity, Motivation model of behaviour (COM-B) was used to categorise the identified adherence interventions. Studies with similar interventions that provided adherence outcome data per group were analysed to establish pooled intervention effect. Protocol registration with Propsero: (CRD42016033677). RESULTS of the 20 trials included (n = 4419), five provided data per group for adherence outcome. Meta-analysis of four studies (n = 482), containing interventions exploring the way exercise is delivered, demonstrated significantly better adherence in the intervention group (n = 166 experimental, n = 161 control Fixed effects model (FEM), SMD = 0.48 95% CI [0.26-0.70] P < 0.0001 I2 = 0%, very low GRADE evidence). Within this limited evidence base, interventions using telecommunication and the integration of exercise into activities of daily living appear most promising when delivering exercise at home. Meta-analysis to explore the effect that these interventions to improve adherence had on balance (n = 166 experimental, n = 161 control Random-effects model (REM), SMD = 0.82, 95% CI [-1.20-2.84] P = 0.43 I2 = 52%) and gait (n = 59 experimental, n = 56 control REM, SMD = 0.29, 95% CI [-1.62-2.20] P = 0.77 I2 = 48%), found no statistically significant effect. CONCLUSIONS adherence to exercise can be positively influenced; however, insufficient data exists to support any single intervention that also achieves effective outcomes for balance and gait.
PoPPy: A Point Process Toolbox Based on PyTorch

PoPPy is a Point Process toolbox based on PyTorch, which achieves flexible designing and efficient learning of point process models. It can be used for interpretable sequential data modeling and analysis, e.g., Granger causality analysis of multi-variate point processes, point process-based simulation and prediction of event sequences. In practice, the key points of point process-based sequential data modeling include: 1) How to design intensity functions to describe the mechanism behind observed data? 2) How to learn the proposed intensity functions from observed data? The goal of PoPPy is providing a user-friendly solution to the key points above and achieving large-scale point process-based sequential data analysis, simulation and prediction.
Inhibition of peptidyl-prolyl cis-trans isomerase B mediates cyclosporin A-induced apoptosis of islet β cells

Cyclosporin A (CsA) is widely used as an immunosuppressor in the context of organ transplantation or autoimmune disorders. Recent studies have revealed the detrimental effects of CsA on insulin resistance and pancreatic β cell failure; however, the molecular mechanisms are unknown. The present study sought to confirm the associations between CsA and β cell failure, and to investigate the roles of proinsulin folding and endoplasmic reticulum (ER) stress in CsA-induced β cell failure. The viability of MIN6 cells treated with CsA was evaluated with MTT assay. Expression levels of insulin, peptidyl-prolyl cis-trans isomerase B (PPIB), cleaved caspase-3, phospho-protein kinase R (PKR)-like endoplasmic reticulum kinase (p-PERK), PKR-like endoplasmic reticulum kinase (PERK), binding immunoglobulin protein (BIP), and C/EBP homologous protein (CHOP) were detected via reducing western blot assay. Non-reducing western blot analysis was performed to examine the expression of misfolded proinsulin peptides. The proliferation of MIN6 cells was not inhibited by CsA at concentrations <1 µmol/l. CsA treatment resulted in the decreased expression of insulin and PPIB; however, it also increased the phosphorylation of PERK, and upregulated the expression of PERK, BIP, CHOP and cleaved caspase-3. The results indicated that CsA could induce pancreatic β cell dysfunction and the potential mechanism underlying this phenomenon may be PPIB-associated proinsulin misfolding, which in turn induces ER stress in β cells.
Participatory arts in care settings: A multiple case study: Innovative practice

This paper describes two case studies of arts interventions in UK care settings. Visual arts and dance movement interventions were regularly held in two settings. This paper draws on data from qualitative interviews, reflective diary sheets and narrative monitoring reports to examine the content, context, and process of the arts interventions within the care settings. Activity coordinators play a crucial role in the success of arts interventions in care setting through their knowledge and support of residents. We recommend that preparatory consultations should take place between arts practitioners and care personnel, as this seems to improve participation and overall satisfaction.
DC/TMD Examiner Protocol: Longitudinal Evaluation on Interexaminer Reliability

Objectives The objectives of this study were to assess the interexaminer agreement between one “reference” (gold standard) and each of two examiners, using the DC/TMD examination method, Axis I and to evaluate whether a recalibration changed reliability values. Methods Participants (4 healthy and 12 TMD patients) in 2013 underwent a clinical examination according to DC/TMDs, Axis I. In 2014, additionally 16 participants (4 healthy and 12 TMD patients) were recruited. Two trainee examiners (one more experienced) and one “reference examiner” (gold standard) at both sessions assessed the participants. Calibration preparation (2013): The clinical protocol was sent to the trainee examiners with a request that its verbal commands should be learned by heart. An eight-hour-course was provided on the day preceding the examination session day. Recalibration preparation (2014): The same examiners in advance to this year's examination session were also asked to recapture the protocol's instructions (verbal commands to be learned by heart) and go through the information from the 2013 course and encouraged to contact by e-mail in case of unclear subjects. At a meeting prior to the examination session, they were also given the opportunities to ask questions. The interexaminer agreements in 2013 and 2014 between the “reference” and each examiner were analysed using Bland–Altman plots, intraclass correlation coefficient, Cohen's kappa, and consistency values. Results For the majority of the gathered data, no clear change of agreement between 2013 and 2014 could be observed, and only one muscle zone in 2014 could show any clear difference in agreement between the examiners. Conclusions No clear and consistent difference in the level of agreement between the two examiners could be observed, although one was more experienced than the other. Likewise, for most components of the DC/TMD tool, recalibration of examiners did not change the reliability findings.
Arm Gesture Recognition using a Convolutional Neural Network

In this paper we present an approach towards arm gesture recognition that uses a Convolutional Neural Network (CNN), which is trained on Discrete Fourier Transform (DFT) images that result from raw sensor readings. More specifically, we use the Kinect RGB and depth camera and we capture the 3D positions of a set of skeletal joints. From each joint we create a signal for each 3D coordinate and we concatenate those signals to create an image, the DFT of which is used to describe the gesture. We evaluate our approach using a dataset of hand gestures involving either one or both hands simultaneously and compare the proposed approach to another that uses hand-crafted features.
Deep Q Learning Based High Level Driving Policy Determination

With the commercialization of various Driver Assistance Systems (DAS), those vehicles have some autonomous functions like Smart Cruise Control (SCC) and Lane Keeping System (LKS). It is believed that autonomous driving can be achieved by combining the DAS functions in the limited situations such as on highways. However, in order to coordinate the DAS functions for autonomous driving, a supervisor is needed to select an appropriate DAS function. In this paper, we propose a method for training a supervisor that selects proper DAS by deep reinforcement learning. The driving policy operates based on camera images and LIDAR data that are accessible in autonomous vehicles. Therefore, deep reinforcement learning network model is designed to analyze both camera image and LIDAR data. This system aims to drive in simulated traffic situation of highway without collision and with high speed. Unlike the systems which learn how to throttle, brake and steering directly, the proposed method can guarantee safe driving because the learned driving policy is based on the existing commercialized DAS functions. In order to verify the algorithms, a simulation tool is developed using Unity for highway environment with multiple vehicles and autonomous driving performance is compared with the proposed supervisor.
The Impact of Chronic Discogenic Low Back Pain: Costs and Patients' Burden

Introduction Chronic discogenic low back pain (CDP) is frequently diagnosed in patients referred to specialized pain clinics for their back pain. The aim of this study is to assess the impact of CDP both on the individual patient and on society. Materials and Methods Using the baseline records of 80 patients in a randomized trial assessing the effectiveness of a new intervention for CDP, healthcare and societal costs related to back pain are calculated. Furthermore, the impact of the condition on perceived pain, disability, health-related quality of life, Quality of life Adjusted Life Years (QALY), and QALY loss is assessed. Results Using the friction costs approach, we found that the annual costs for society are €7,911.95 per CDP patient, 51% healthcare and 49% societal costs. When using the human capital approach, total costs were €18,940.58, 22% healthcare and 78% societal costs. Healthcare costs were mainly related to pain treatment. Mean pain severity was 6.5 (0–10), and 46% suffered from severe pain (≥7/10). Mean physical limitations rate was 43.7; 13.5% of the patients were very limited to disabled. QALY loss compared to a healthy population was 64%. Discussion This study shows that in patients with CDP referred to a pain clinic, costs for society are high and the most used healthcare resources are pain therapies. Patients suffer severe pain, are physically limited, and experience a serious loss in quality of life.
Calcium binding of the antifungal protein PAF: Structure, dynamics and function aspects by NMR and MD simulations

Calcium ions (Ca2+) play an important role in the toxicity of the cysteine-rich and cationic antifungal protein PAF from Penicillium chrysogenum: high extracellular Ca2+ levels reduce the toxicity of PAF in the sensitive model fungus Neurospora crassa in a concentration dependent way. However, little is known about the mechanistic details of the Ca2+ ion impact and the Ca2+ binding capabilities of PAF outside the fungal cell, which might be the reason for the activity loss. Using nuclear magnetic resonance (NMR), isothermal titration calorimetry and molecular dynamics (MD) simulations we demonstrated that PAF weakly, but specifically binds Ca2+ ions. MD simulations of PAF predicted one major Ca2+ binding site at the C-terminus involving Asp53 and Asp55, while Asp19 was considered as putative Ca2+ binding site. The exchange of Asp19 to serine had little impact on the Ca2+ binding, however caused the loss of antifungal activity, as was shown in our recent study. Now we replaced the C-terminal aspartates and expressed the serine variant PAFD53S/D55S. The specific Ca2+ binding affinity of PAFD53S/D55S decreased significantly if compared to PAF, whereas the antifungal activity was retained. To understand more details of Ca2+ interactions, we investigated the NMR and MD structure/dynamics of the free and Ca2+-bound PAF and PAFD53S/D55S. Though we found some differences between these protein variants and the Ca2+ complexes, these effects cannot explain the observed Ca2+ influence. In conclusion, PAF binds Ca2+ ions selectively at the C-terminus; however, this Ca2+ binding does not seem to play a direct role in the previously documented modulation of the antifungal activity of PAF.