Miracle-dz/UniFAR-FTUs huggingface dataset:
Presence of leptin in breast cell lines and breast tumors.

Leptin is the product of the ob gene, reported to be secreted exclusively from adipocytes and thought to control satiety by providing information to the central nervous system. However, the function of leptin appears to be more complex because multiple studies demonstrate its role in hematopoiesis, reproduction, and immunity. In addition, several nonadipose sources of leptin have been reported. The purpose of this study was to examine several breast cancer cell lines and ductal carcinomas of the breast for expression of leptin messenger RNA (mRNA) and protein. For tumor studies, specimens were preassayed for contaminating adipose tissue. Northern blot analyses demonstrated leptin mRNA in several breast cancer cell lines (MCF-7, T47D, and MDA-MB-231), a normal breast epithelial cell line (MCF10A), and four breast tumors. Leptin protein was identified in T47D breast cancer cells by indirect immunofluorescent staining and in samples of the same breast tumors used for Northern studies by enzyme-linked immunosorbent assays (ELISA). This preliminary study suggests that leptin is expressed in malignant epithelial cells of the breast. Further investigation is needed to determine whether this protein plays a role in breast carcinogenesis.
A technique for designing self-checking logic for FPGAs

A technique for designing self-checking combinational logic for implementation in look-up table based FPGAs is presented. The technique is based on mapping Boolean functions into FPGAs such that self-checking features are automatically incorporated into designs, allowing on-line detection of faults in the combinational function block within any CLB of an FPGA, and on the interconnect lines that connect these blocks.
Dynamic Load Alleviation in Wake Vortex Encounters

This paper introduces an integrated approach for flexible-aircraft time-domain aeroelastic simulation and controller design suitable for wake encounter situations. The dynamic response of the vehicle, which may be subject to large wing deformations in trimmed flight, is described by a geometrically nonlinear finite-element model. The aerodynamics are modeled using the unsteady vortex lattice method and include the arbitrary time-domain downwash distributions of a wake encounter. A consistent linearization in the structural degrees of freedom enables the use of balancing methods to reduce the problem size while retaining the nonlinear terms in the rigid-body equations. Numerical studies on a high-altitude, long-endurance aircraft demonstrate the reduced-order modeling approach for load calculations in wake vortex encounters over a large parameter space. Closed-loop results finally explore the potential of combining feedforward/feedback H∞ control and distributed control surfaces to obtain significant load .
A graph theoretic approach for synthesizing very low-complexityhigh-speed digital filters

We present computation reduction techniques which can either be used to obtain multiplierless implementation of finite impulse response (FIR) digital filters or to further improve multiplierless implementation obtained by currently used techniques. Although presented in the FIR filtering framework, these ideas are also directly applicable to any task/application which can be expressed as multiplication of vectors by scalars. The presented approach is to remove computational redundancy by reordering computation. The reordering problem is formulated using a graph in which vertices represent coefficients and edges represent resources required in a computation using the differential coefficient defined by the difference of the vertices joined by the edge. This interpretation leads to various methods for computation reduction for which simple polynomial run time algorithms are presented. It is shown that about 20% reduction in the number of add operations per coefficient can be obtained over the conventional multiplierless implementations. It is also shown that implementations requiring less than one adder per coefficient can be obtained using the presented approaches when using nonuniformly scaled coefficients quantized from infinite precision representation by simple rounding.
Dual-mode decision fusion for fingerprint and finger vein recognition based on image quality evaluation

To overcome the influence of image quality on single-mode recognition systems, a novel fingerprint and finger vein dual-mode recognition algorithm based on image quality evaluation is proposed. This method fuses the image quality scores of both fingerprint and finger vein in a novel way, to overcome the influence of image quality on identification results. Two classifiers are then designed for fingerprint and finger vein recognition, respectively. The final recognition is achieved by the fusion of the two quality scores and classifiers' recognition results at the decision level. This is a novel quality evaluation of both fingerprint and finger vein. This method not only overcomes the limitations of image quality on single-modal biometrics, but also effectively improves the recognition performance of the system, thus demonstrating the validity of the method when used for multimodal biometric identification.
Feed-forward polarization-mode dispersion compensation with four fixed differential group delay elements

We report a feed-forward polarization-mode dispersion (PMD) compensator with four fixed differential group delay elements, which is capable of compensating for any first- and second-order PMD in a transmission fiber. The compensator consists of seven control parameters [or seven degrees of freedom (DOF)]. An extra DOF is employed to ensure analytical solutions of control parameters for the case of random changes of PMD vectors. Our model shows excellent robustness to possible perturbations by Monte Carlo simulations.
Adaptive stochastic minimization for measuring marine oil spill extent in synthetic aperture radar images

Abstract A binary segmentation scheme, based on the Markov random field theory, is presented. In order to obtain a more integrated label field, the simulated annealing schedule is modified for performing a joint conditional estimation of model parameters. To reach a finer detection, the pixel neighborhood system of the a priori model is continuously updated at each cycle of the optimization algorithm. Maximum a posteriori is the central criterion of these algorithms. The proposed processing scheme is applied to a sequence of Envisat/ASAR images of the Deepwater Horizon disaster of the Gulf of Mexico in the spring of 2010. Initial oil spills statistical parameters are extracted by visual analysis, but they are updated during the minimization cycles. The proposed scheme, when compared with a conventional Markov random field one, provides a better detection of fine structures. In addition, facing the complex ocean phenomena reflected in the synthetic aperture radar images, the final label field results are extremely well defined.
One-bit feedback algorithm with decreasing step size for distributed beamforming

An iterative algorithm with a decreasing step size is proposed for distributed transmit beamforming to achieve carrier phase alignment at the receiver. The transmitters apply random perturbations on their phase offsets and adjust them based on one bit feedback from the receiver in each iteration. The perturbation step size becomes smaller when the phase angles at the receiver get closer to coherence. The step size is decreased by a specified ratio every time the number of successive failed perturbations surpasses a certain threshold. The proposed algorithm has an improvement in the convergence speed of phase alignment compared to the original iterative algorithm in the literature which has a fixed step size during the convergence process.
Lack of Chemokine Receptor CCR5 Promotes Murine Fulminant Liver Failure by Preventing the Apoptosis of Activated CD1d-Restricted NKT Cells1

Fulminant liver failure (FLF) consists of a cascade of events beginning with a presumed uncontrolled systemic activation of the immune system. The etiology of FLF remains undefined. In this study, we demonstrate that CCR5 deficiency promotes the development of acute FLF in mice following Con A administration by preventing activated hepatic CD1d-restricted NKT cells (but not conventional T cells) from dying from activation-induced apoptosis. The resistance of CCR5-deficient NKT cells from activation-induced apoptosis following Con A administration is not due to a defective Fas-driven death pathway. Moreover, FLF in CCR5-deficient mice also correlated with hepatic CCR5-deficient NKT cells, producing more IL-4, but not IFN-γ, relative to wild-type NKT cells. Furthermore, FLF in these mice was abolished by IL-4 mAb or NK1.1 mAb treatment. We propose that CCR5 deficiency may predispose individuals to the development of FLF by preventing hepatic NKT cell apoptosis and by regulating NKT cell function, establishing a novel role for CCR5 in the development of this catastrophic liver disease that is independent of leukocyte recruitment.
ISOLATION , IDENTIFICATION AND DRUG RESISTANCE PATTERNS OF METHICILIN RESISTANT STAPHYLOCOCCUS AUREUS FROM MASTITIC COW ’ S MILK FROM SELECTED DAIRY FARMS IN AND AROUND KOMBOLCHA

A cross sectional study was conducted from January 2015 to May 2015 in and around kombolcha town, Eastern Amhara, to isolate and identify methicilin resistant S. aureus and their resistance to different antimicrobials and also identify risk factors associated with the occurrence of dairy cow mastitis. A total of 150 dairy cows were included during the study period. A total of 600 quarters were examined to detect clinical and subclinical mastitis by physical examinations of udder and milk and California mastitis Test, respectively. The prevalence of mastitis was 56%. Out of this, 10% and 46% were clinical and subclinical respectively. Among potential risk factors considered from the farm attributes, age, milking hygiene, parity, and floor system had significant (p=<0.05) effect on the prevalence of mastitis. However, breed, previous treatment and lactation period have not been a significant potential risk factor on the occurrence of mastitis. Staphylococcus aureus was isolated at a rate of 11 (73.3%) and 29 (42%) in clinical and subclinical mastitis, respectively. The result showed that the occurrence of Staphylococcus aureus in clinical mastitis were found to be significantly higher than subclinical mastitis (p=0.028). The present study showed that S. aureus was resistant to penicillin G (100%), Amoxicillin (100%), cefoxtin (42.7%) and tetracycline (77.4%) however all the isolates were found to be totally (100%) susceptible to the gentamycin disc. Out of the resistance S. aureus isolates, 24 (45.3%) were found to be multidrug resistant against 4 antibiotic discs primarily to penicillin G, ampicillin, cefoxtin, and erythromycin. The development of antimicrobial resistance is nearly always as a result of repeated therapeutic and/or indiscriminate use of them. Regular antimicrobial sensitivity testing helps to select effective antibiotics and to reduce the problems of drug resistance development towards commonly used antibiotics. In conclusion, among different risk factors, age of the animal, milking hygiene, parity and floor type were critical for the occurrence of mastitis. Mastitis caused by S. aureus is one of the major problems of dairy cows in milk production in the study area.
Proteolytic processing of the coronavirus infectious bronchitis virus 1a polyprotein: identification of a 10-kilodalton polypeptide and determination of its cleavage sites

Proteolytic processing of the polyprotein encoded by mRNA 1 is an essential step in coronavirus RNA replication and gene expression. We have previously reported that an open reading frame (ORF) 1a-specific proteinase of the picornavirus 3C proteinase group is involved in processing of the coronavirus infectious bronchitis virus (IBV) 1a/1b polyprotein, leading to the formation of a mature viral protein of 100 kDa. We report here the identification of a novel 10-kDa polypeptide and the involvement of the 3C-like proteinase in processing of the ORF 1a polyprotein to produce the 10-kDa protein species. By using a region-specific antiserum, V47, raised against a bacterial-viral fusion protein containing IBV sequence encoded between nucleotides 11488 and 12600, the 10-kDa polypeptide was detected in lysates from both IBV-infected and plasmid DNA-transfected Vero cells. Coexpression, deletion, and mutagenesis studies showed that this novel polypeptide was encoded by ORF 1a from nucleotide 11545 to 11878 and was cleaved from the 1a polyprotein by the 3C-like proteinase domain. Evidence presented suggested that a previously predicted Q-S (Q3783 S3784) dipeptide bond encoded by ORF 1a between nucleotides 11875 and 11880 was responsible for the release of the C terminus of the 10-kDa polypeptide and that a novel Q-N (Q3672 N3673) dipeptide bond encoded between nucleotides 11542 and 11547 was responsible for the release of the N terminus of the 10-kDa polypeptide.
A Note on the Modified Likelihood Ratio Test for Homogeneity in Beta Mixture Models

This article presents a note on the modified likelihood ratio test for homogeneity in beta mixture models. Under consistency of the penalized maximum likelihood estimators, the limiting distribution of the test statistic converges to the chi-bar-squared distributions. The statistic degenerates to zero with a weight due to the negative definiteness of a complicated random matrix. The probability that this matrix is negative definite is related to the parameter values under the homogeneity hypothesis. The dependency pattern enables the introduction of an upper bound on the asymptotic null distribution. Simulation study is investigated to verify the accuracy of the results.
Comparison of edge effects of transverse flux and travelling wave induction heating inductors

In this paper a comparison of the edge-effects in the induction heating of thin aluminium strips by transverse flux (TF) and travelling wave (TW) inductors at power frequencies is presented. The main attention is focused on the choice of the optimal position of the inductor relative to the strip for both systems in order to minimise the unevenness of power density distribution, both in the workpiece cross section and along the strip movement direction. The calculations of the electromagnetic field quantities have been made by 3D finite element models.
Biosynthesis of terpenes and steroids. X. The sterols of some yeast mutants doubly defective in ergosterol biosynthesis.

The sterols of six double mutants of Saccharomyces cerevisiae have been isolated and characterised, and the sterol distribution has been related to the biosynthetic pathway from zymosterol to ergosterol. Hitherto unknown ergosta-5,8-dien-3β-ol and cholesta-7,24-dien-3β-ol have been isolated and characterised.
The role of bevacizumab in colorectal cancer: understanding its benefits and limitations

Introduction: Angiogenesis is a key factor in the development of aberrant blood vessels required for malignant growth, invasion and progression. Inhibiting VEGF is by far the most clinically advanced anti-angiogenic target. Bevacizumab (BV), the only humanized mAb directed against VEGF, is approved for use in multiple tumor types after successful clinical trial results demonstrated benefits in progression-free survival and/or overall survival when combined with common cytotoxic chemotherapies. Areas covered: The review focuses on the use of BV in colorectal cancer, discusses the clinical trial data supporting its increasing use and explores its limitations. Readers will gain a succinct description of the trial data demonstrating a modest survival benefit in metastatic colorectal cancer (mCRC) and the lack of benefit of BV when utilized in the adjuvant setting. A review of common BV toxicities and a discussion about possible BV resistance mechanisms are also provided. Expert opinion: Although BV has demonstrated efficacy in mCRC, there is an urgent need to improve the understanding of its mechanism of action and the development of BV resistance. Furthermore, there is a need for delineating predictive markers of BV efficacy and toxicity.
Integration prospects of electric drives based on back to back converters in industrial smart grid

In this article theoretical and mathematical studies were performed to define integration prospects of electric drives based on back to back converters in an industrial smart grid. Back to back converters can be actively used in operation of supply power system of enterprise as they are able to provide controlled power factor and bidirectional power flow. A back to back converter contains PWM boost rectifier which can carry out a compensation of reactive power in the grid using the increase of the direct current voltage level on the value of the voltage drop on the input inductor. The principle of maximum using consumption current of back to back converter to improve the efficiency was proposed. This principle most appropriately applied for parallel working with a nonlinear load.
Postoperative nausea and vomiting in patients undergoing total abdominal hysterectomy under subarachnoid block: a randomized study of dexamethasone prophylaxis.

BACKGROUND Postoperative nausea and vomiting is a common distressing problem in patients undergoing gynaecological surgery under anaesthesia including central neuraxial blockade, which requires frequent medical interventions. OBJECTIVES We aimed to find out the antiemetic effect of prophylactic dexamethasone for prevention of postoperative nausea and vomiting in patients undergoing total abdominal hysterectomy under subarachnoid block. Influences of dexamethasone on patient satisfaction and postoperative analgesia were also observed as secondary objectives. METHODS This was a prospective, randomized, double blind, placebo controlled study conducted in BPKIHS, from January 2009 to April 2009. This study involved 80 American Society of Anaesthesiologist Physical Status I and II patients undergoing total abdominal hysterectomy under subarachnoid block. Patients were divided into two groups of 40 each to receive either 4 mg of dexamethasone (group D) or normal saline (group N) in volume of 2 ml intravenously 1 hour prior to subarachnoid block. Surgery was allowed to start with block height of at least T8 dermatome. Intraoperative and postoperative nausea and vomiting was observed using nausea and vomiting scale every 4 hour for 24 hours. RESULTS Seven (17.4%) patients in group D and 11 (27.5%) patients in group N had nausea and vomiting in the intraoperative period (P=0.284). Sixteen (40%) patients in group D experienced nausea and vomiting in the postoperative period as compared to 27 (67.5%) in group N (P =0.0136). Accordingly, the mean requirement of rescue antiemetic was less in group D compared to Group N (P=0.042). Further, only 15 (37.5%) patients in group D required postoperative supplemental analgesic as compared to 23 (57.5%) in group N (P=0.058). After 24 hrs of surgery, 26 (65%) patients expressed satisfaction in group D as compared to 16 (40.0%) in group N (P =0.025). CONCLUSIONS Use of dexamethasone prior to subarachnoid block in patients undergoing total abdominal hysterectomy significantly reduces the incidence of nausea and vomiting and the requirement of antiemetic in the postoperative period, with better patient satisfaction.
Survey on predicting and controlling of structure-borne noise from rail transit bridges

Sound radiating from rail transit bridges is a kind of low frequency noise causing annoyance and stress to residents nearby. It may become the dominant noise component when wheel-rail noise is well mitigated. The empirical, analytical and numerical methods that have been developled to predict and control the structure-borne noise from rail transit bridges are reviewed and assessed.
ynergy matrices to estimate fluid wrist movements by surface lectromyography

Although many efforts have been undertaken to develop an interface using surface electromyography (sEMG) to connect the gap between a human and a wrist prosthesis, most of these efforts have offered only static positioning (ON/OFF) of the prosthesis. This study introduced synergy matrices to extract fluid wrist movement intents by sEMG to allow individuals with wrist amputations to use wrist prostheses. A nonnegative muscle synergy matrix was used to map muscle activities in the forearm into four predefined wrist movement intents (flexion/extension and radial/ulnar deviation). The directions of the predefined ynergy matrices rist prosthesis intents were constrained to two perpendicular axes, so each movement spanned only a one-dimensional space. A joint synergy matrix was used to span the whole two-dimensional space by combining the four wrist movement intents. Ten healthy subjects volunteered for a validation experiment, which was built as a virtual environment in which people with wrist amputation could receive myoelectric control training. The results showed that proportional two-degree-of-freedom (DOF) movements could be estimated by usefu otor sEMG. This work could be and studies to examine m
Hybrid Inertial Microwave Reflectometry for mm-Scale Tracking in RFID Systems

This paper proposes a new fine-scale (millimeter level) radio localization and tracking scheme-Hybrid Inertial Microwave Reflectometry-for radio frequency identification and other wireless systems. The scheme combines the backscattered radio frequency signal properties, such as received signal strength and received signal phase, along with reflected inertial data from a tag-mounted accelerometer sensor. Experimental results yield a mean error of 2 mm in ranging accuracy, with a 90% confidence interval of ±1 mm, while tracking a tag moving at a maximum speed of 1.4 m/s.
Inventory of Tools for Dutch Clinical Language Processing

Automated encoding of free-text clinical narratives using concepts from terminological systems is widely performed. However, the majority of natural language processing (NLP) tools and terminological systems involve the English language. As parts of the NLP process are language independent, and tools for various languages are available, an overview is needed to determine the applicability to performing NLP of Dutch medical texts. To this end an inventory of tools is created. A literature study and internet search were performed to describe available components for a Dutch NLP system, enabling to encode Dutch text as structured SNOMED CT output without the need to translate SNOMED CT in Dutch. We have found 31 papers, describing a variety of NLP frameworks and tools for the various NLP components for processing English and Dutch free text. Most of them are suitable for English free text, some of them are (also) usable for Dutch. To enable automated encoding of Dutch free text narratives, further research is needed to create a spelling checker, a negation detector, a domain-specific abbreviation/acronym list, and a concept mapper (to map Dutch terms to concepts in a terminological system). Furthermore evaluation of performance for the Dutch 'medical' language is needed.
Measurement techniques for ferromagnetic materials using a stripline

Polymer composites offer the promise for dramatically changing the design environment available to the antenna and microwave interconnect communities. As compared to metamaterials that have garnered so much attention in recent years, polymer composites consist of a polymer system with dissimilar material inclusions designed to modify one or more properties of the composite. For the purposes of this paper, we are most interested in polymer composites with engineered electric and magnetic properties at radio frequencies (RF). It is necessary to test the properties of candidate RF polymers across a wide bandwidth. Typically, only small laboratory samples of each material are available for testing. This paper describes the rationale, and presents some example data, for testing using a stripline field applicator.