Miracle-dz/UniFAR-FTUs huggingface dataset:
The Potential Relationship Between a Cognitive Dissonance State and Musculoskeletal Injury: A Systematic Review

OBJECTIVE The objective of this systematic review was to investigate the potential link between cognitive dissonance or its related constructs (emotional dissonance, emotional labor) and musculoskeletal disorders. BACKGROUND The etiology of musculoskeletal disorders is complex, as pain arises from complex interactions among physical, social, and psychological stressors. It is possible that the psychological factor of cognitive dissonance may contribute to the etiology and/or maintenance of musculoskeletal disorders. METHOD MEDLINE, APA PsycInfo, and CINAHL Plus databases were searched for studies investigating cognitive dissonance or its related constructs as exposure(s) of interest and outcomes related to physical health (including, but not limited to, musculoskeletal pain). Risk of bias was assessed using the Appraisal tool for Cross-Sectional Studies (AXIS) tool. RESULTS The literature search yielded 7 studies eligible for inclusion. None of the included studies investigated cognitive dissonance directly but instead investigated dissonance-related constructs of emotional dissonance and emotional labor, in which a mismatch between required and felt emotions might elicit a psychological response consistent with the cognitive dissonance state. Moderate effect sizes between dissonance-related constructs and musculoskeletal disorders were noted (OR 1.25-2.22). CONCLUSION There is likely a relationship between the two factors studied. However, as the included studies were cross-sectional in nature, a causal relationship between cognitive dissonance-related constructs and musculoskeletal disorders cannot be inferred. Therefore, future study proposing and validating a causal pathway between these variables is warranted. APPLICATION Cognitive dissonance and its related constructs may serve as risk factors for musculoskeletal disorders that have not been considered previously.
Cervical disc arthroplasty combined with two‐level ACDF for the treatment of contiguous three‐level cervical degenerative disc disease: A comparative study

To compare the differences among constructs with one‐level cervical disc arthroplasty (CDA) and two‐level anterior cervical discectomy and fusion (ACDF). A retrospective study was conducted involving patients who underwent one‐level CDA and two‐level ACDF between June 2012 and July 2020. According to the different locations of CDA and ACDF, we divided the constructs into three types: type Ⅰa: CDA‐ACDF‐ACDF; type Ⅰb: ACDF‐CDA‐ACDF; type Ⅰc: ACDF‐ACDF‐CDA. The differences of clinical and radiological outcomes were evaluated. Fifty‐three patients were included with 29 in type Ⅰa group, 11 in type Ⅰb group, and 13 in type Ⅰc group. After surgery, all groups showed significant improvement in apanese Orthopedic Association, Neck Disability Index, and Visual Analog Scale scores (p < 0.001). Range of motion (ROM) of the total cervical spine in type Ⅰc group decreased significantly compared with those in type Ⅰa and type Ⅰb groups (p < 0.05). No significant differences in ROM of the arthroplasty segment and the variations in ROM of the superior adjacent segment were observed among the three groups. The fusion rates of the superior ACDF segments were significantly higher at 6 and 12 months postoperatively than those of the inferior ACDF segments (p < 0.05). The clinical outcomes were similar among constructs concerning different locations of CDA and ACDF in three‐level hybrid surgery. ROM of the cervical spine in type Ⅰc group decreased significantly compared with that in type Ⅰa and type Ⅰb groups. The fusion rates of superior ACDF segments were higher at early time points after surgery than those of inferior ACDF segments.
Anxiety, Depression and Death Anxiety in Individuals with COVID-19

This study aimed to determine the death anxiety, anxiety, and depression levels of the individuals staying at the hospital due to COVID-19. The study recruited 300 patients with confirmed COVID-19 who were staying at specialized clinics in the hospital. Three tools – A Patient Information Form, the Death Anxiety Scale (DAS), and the Hospital Anxiety and Depression Scale (HADS)–were used to collect data. The findings of the present study revealed that 28.7% of the participants were at a high risk for developing anxiety and 45.0% were equally at a high risk for developing depression. 33.3% of the participants suffered from high level of death anxiety. There was a positive and highly significant correlation between their death anxiety and their anxiety and depression scores (p < .001). Accordingly, more evidence-based studies need to be conducted that examine how effective non-pharmacological practices are at helping COVID-19 patients by identifying their anxiety, depression, and death anxiety. Furthermore, nurses need to take care of patient care in a holistic manner that would include addressing patients’ psychological needs alongside their physical problems.
Changes in utilisation of optometry services with a non-targeted publicly-funded health care voucher system

ABSTRACT Clinical relevance Understanding the impact of a health care voucher scheme and service access barriers could facilitate optometry service promotion to the older population. Background A voucher is one strategy to improve the utilisation of the different health care services available in the private sector. This study aims to explore how a health care voucher system for older people impacts utilisation of optometry services from the perspective of service users and service providers. Methods People aged 65 years or above were recruited to fill in a structured questionnaire studying the usage characteristics and access barriers of optometry services and the health care voucher. Views from the optometrists about the voucher scheme were collected by questionnaire. Results A total of 1156 valid questionnaires from eligible voucher users was collected. Results showed that 53.7% (621/1156) of participants had used optometry services within the past 2 years. Lack of familiarity with services provided, professional fees, and prices of spectacles were the main barriers to using optometry services. Of those participants who had used the voucher for optometry services previously, 80.4% (284/353) had an eye examination in the past 2 years. Among 389 optometrists who participated in the study, over 80% agreed that the voucher scheme improved awareness of major eye conditions and access to prescription spectacles when necessary. Conclusion The health care voucher for older people improved access to optometry services. Access could be further improved by increasing price transparency of professional services and prescription spectacles. Responses from optometry service providers supported the view that the voucher scheme improved access to, and utilisation of, preventive care services.
COVID-19 Experiences of Relatives of Nursing Home Residents

Nursing home residents comprise a disproportionate share of coronavirus-related deaths in the United States. Additionally, lockdown restrictions disrupted residents’ relationships with their family members to an unknown extent. This study explored family members’ perceived family role and interactions with nursing home residents and staff during the COVID-19 pandemic. Using a qualitative descriptive approach, 10 family members were interviewed using a semi-structured guide. Interviews were audio-recorded and transcribed verbatim, and data were analyzed using Braun and Clarke’s Reflexive Thematic analysis. Themes and subthemes indicated that family members accounted for residents’ care in new ways, found existing relationships becoming amplified under stress, maintained connections through creative alternatives, and also felt powerless to provide care, despite their knowledge and experience. Family members increasingly relied on staff to meet residents’ care needs and provide updates, and often desired to provide assistance and companionship beyond what policy permitted, representing a major opportunity for improving experiences.
Voluntary Cough Testing as a Clinical Indicator of Airway Protection in Cervical Spinal Cord Injury

Voluntary cough testing (VCT) may be useful for determining aspiration risk in neurogenic dysphagia; however, has yet to be investigated in traumatic cervical spinal cord injury (tCSCI). The study explored if VCT may elucidate swallowing safety and kinematics related to airway protection in tCSCI survivors.
High efficiency Schottky junction solar cells by co-doping of graphene with gold nanoparticles and nitric acid

We have reported an effective method to enhance the efficiency of graphene-on-Si (Gr/Si) Schottky junction solar cells by co-doping of graphene with Au nanoparticles (NPs) and HNO3. Both Au NPs decoration and HNO3 treatment lead to p-type doping of graphene, and their combination is confirmed to be a more effective approach for achieving the higher work function and enhanced electrical conductivity of graphene. Consequently, the power conversion efficiency of Gr/Si solar cells is increased by 2.6 times, with a maximum value of 10.20%. This work suggests that the co-doping might be a promising way to realize high performance Gr/Si solar cells.
Effects of climate change on forest plantation productivity in Chile

Forest plantations in Chile occupy more than 2.2 million ha and are responsible for 2.1% of the GDP of the country's economy. The ability to accurately predictions of plantations productivity under current and future climate has an impact can enhance on forest management and industrial wood production. The use of process‐based models to predict forest growth has been instrumental in improving the understanding and quantifying the effects of climate variability, climate change, and the impact of atmospheric CO2 concentration and management practices on forest growth. This study uses the 3‐PG model to predict future forest productivity Eucalyptus globulus and Pinus radiata. The study integrates climate data from global circulation models used in CMIP5 for scenarios RCP26 and RCP85, digital soil maps for physical and chemical variables. Temporal and spatial tree growth inventories were used to compare with the 3‐PG predictions. The results indicated that forest productivity is predicted to potentially increase stand volume (SV) over the next 50 years by 26% and 24% for the RCP26 scenario and between 73% and 62% for the RCP85 scenario for E. globulus and P. radiata, respectively. The predicted increases can be explained by a combination of higher level of atmospheric CO2, air temperatures closer to optimum than current, and increases in tree water use efficiency. If the effect of CO2 is not considered, the predicted differences of SV for 2070 are 16% and 14% for the RCP26 scenario and 22% and 14% for RCP85 for the two species. While shifts in climate and increasing CO2 are likely to benefit promote higher productivity, other factors such as lack insufficient availability of soil nutrients, events such as increasing frequency and duration of droughts, longer periods of extreme temperatures, competing vegetation, and occurrence of new pests and diseases may compromise these potential gains.
Lung Dysfunction and Increased Arterial Stiffness: Causality or Epiphenomenon?

Identifying individuals at high risk for cardiovascular (CV) events is important to allow early preventive strategies. In this regard, aortic stiffness is an important factor involved in the pathophysiology of CV disease in healthy subjects and a number of different populations including patients with an evidence of chronic in ﬂ ammation, as recently evidenced in a position statement from the European Society of Hyper-tension (ESH) Working Group on Vascular Structure and Function and the Association for Research into Arterial Structure and Physiology (ARTERY) Society. 1 Brie ﬂ y, at the level of the arterial wall, in ﬂ ammation and oxidative stress leads to the reduced bioavailability of nitric oxide, increased production of elastase and collagenase, hyperplasia, and cross-differentiation of vascular smooth muscle cells that in turn lead to functional (i.e., endothelial dysfunction) and structural alterations of the arterial wall (i.e., disruption of normal elastin and collagen and substitution with altered proteins) and arterial stiffening. 1 Recent ﬁ ndings suggest that aortic stiffening is partially reverted in the long-term after resolution of severe in ﬂ ammation. 2 , 3 Peter in one (FEV , of lung the maximum of be expired in one carotid-femoral pulse wave (cfPWV, a baseline 20 nding
Targeted delivery and anticancer effects of Chrysin-loaded chitosan-folic acid coated solid lipid nanoparticles in pancreatic malignant cells

Abstract The aim of this survey was to load Chrysin (CHY) on solid lipid nanoparticles (SLNs) and decorate the nanoparticles with folate-bound chitosan to increase the effectiveness of the treatment. CHY-SCF-NPs were synthesized by homogenizing and sonication methods and characterized. FA binding and encapsulation efficiency (HPLC), antioxidant capacity (ABTS and DPPH), cell viability assay (MTT), programmed cell death analysis (fluorescence staining, flow cytometry, and qPCR), and angiogenesis (CAM and molecular analysis) assay were done for assessment of therapeutic efficiency of CHY-SCF-NPs. Increases in size and change in surface charge of CHY-SLNs (PS: 84.3 nm and ZP: −18 mV) were reported after coating with folate-bound chitosan (PS: 125 nm and ZP: +34.9 mV). CHY-SCF-NPs inhibited PANC, MCF-7, A2780, and HepG2 as malignant cells and HFF as normal cells with IC50∼53, 55, 249, and >250 µg/mL, respectively. Also, CHY-SCF-NPs scavenged ABTS (IC50: 123.73 µg/mL), and DPPH (IC50: 108.7 µg/mL) free radicals and suppressed angiogenesis in the CAM and qPCR assays. Up-regulation of Bax and caspase 9 genes as well as the fluorescence staining and cell cycle results confirmed the pro-apoptotic properties of CHY-SCF-NPs. CHY-SCF-NPs can be considered a promising anti-cancer candidate for preclinical and clinical studies of pancreatic cancer.
The OTUD6B‐LIN28B‐MYC axis determines the proliferative state in multiple myeloma

Deubiquitylases (DUBs) are therapeutically amenable components of the ubiquitin machinery that stabilize substrate proteins. Their inhibition can destabilize oncoproteins that may otherwise be undruggable. Here, we screened for DUB vulnerabilities in multiple myeloma, an incurable malignancy with dependency on the ubiquitin proteasome system and identified OTUD6B as an oncogene that drives the G1/S‐transition. LIN28B, a suppressor of microRNA biogenesis, is specified as a bona fide cell cycle‐specific substrate of OTUD6B. Stabilization of LIN28B drives MYC expression at G1/S, which in turn allows for rapid S‐phase entry. Silencing OTUD6B or LIN28B inhibits multiple myeloma outgrowth in vivo and high OTUD6B expression evolves in patients that progress to symptomatic multiple myeloma and results in an adverse outcome of the disease. Thus, we link proteolytic ubiquitylation with post‐transcriptional regulation and nominate OTUD6B as a potential mediator of the MGUS‐multiple myeloma transition, a central regulator of MYC, and an actionable vulnerability in multiple myeloma and other tumors with an activated OTUD6B‐LIN28B axis.
Jaw mechanics in macrophagous lamniform sharks and their evolutionary and functional implications

Jaw mechanics of lamniform sharks were examined three‐dimensionally to analyze the variability in jaw shape and the evolution of the jaw system based on the extant macrophagous species. Three‐dimensional lever analysis was applied to lamniform jaws to calculate bite force at each tooth relative to maximum input force from jaw adductor muscles for interspecific comparison of efficiency in lamniform jaws. When total input force from the jaw adductor muscles on both working and balancing sides of the skull is considered, input force varies along the jaw because the contribution by balancing side muscles is not constant. The phylogenetically basal‐most species, Mitsukurina owstoni, has the least efficient jaws due to posteriorly positioned jaw adductor muscles. Our study shows that the higher efficiency of jaws is regarded as apomorphic in lamniform phylogeny owing to the anterior extension of jaw adductor muscles relative to M. owstoni and a relative decrease in jaw length in relation to width seen in some species, both of which increase leverage. Differences in the efficiency of jaws among derived genera or species are due to the morphology of their jaws. The relationship between calculated bite force relative to maximum input force and tooth morphology indicates low relative bite forces being exerted at anteriorly located, narrow, piercing teeth, whereas high relative bite forces at posteriorly located, broad, cutting, or crushing‐type teeth. As a result, the biting pressure during feeding is maintained throughout the tooth series.
Dispersal, kin aggregation, and the fitness consequences of not spreading sibling larvae

Abstract Dispersal has far‐reaching implications for individuals, populations, and communities, especially in sessile organisms. Escaping competition with conspecifics and with kin are theorized to be key factors leading to dispersal as an adaptation. However, manipulative approaches in systems in which adults are sessile but offspring have behaviors is required for a more complete understanding of how competition affects dispersal. Here, we integrate a series of experiments to study how dispersal affects the density and relatedness of neighbors, and how the density and relatedness of neighbors in turn affects fitness. In a marine bryozoan, we empirically estimated dispersal kernels and found that most larvae settled within ~1 m of the maternal colony, although some could potentially travel at least 10s of meters. Larvae neither actively preferred or avoided conspecifics or kin at settlement. We experimentally determined the effects of spreading sibling larvae by manipulating the density and relatedness of settlers and measuring components of fitness in the field. We found that settler density reduced maternal fitness when settler neighbors were siblings compared with when neighbors were unrelated or absent. Genetic markers also identified very few half sibs (and no full sibs) in adults from the natural population, and rarely close enough to directly interact. In this system, dispersal occurs over short distances (meters) yet, in contrast with expectations, there appears to be limited kinship between adult neighbors. Our results suggest that the limited dispersal increases early offspring mortality when siblings settle next to each other, rather than next to unrelated conspecifics, potentially reducing kinship in adult populations. High offspring production and multiple paternity could further dilute kinship at settlement and reduce selection for dispersal beyond the scale of 10s of meters.
The future clinical implications of trained immunity

ABSTRACT Introduction Trained Immunity (TI) refers to the long-term modulation of the innate immune response, based on previous interactions with microbes, microbial ligands, or endogenous substances. Through metabolic and epigenetic reprogramming, monocytes, macrophages, and neutrophils develop an enhanced capacity to mount innate immune responses to subsequent stimuli and this is persistent due to alterations at the myeloid progenitor compartment. Areas covered The purpose of this article is to review the current understanding of the TI process and to discuss its potential clinical implications in the near future. We address the evidence of TI involvement in various diseases, the currently developed new therapy, and discuss how TI may lead to new clinical tools to improve existing standards of care. Expert opinion The state of the art in this domain has made considerable progress, linking TI-related mechanisms in multiple immune-mediated pathologies, starting with infections to autoimmune disorders and cancers. As a relatively new area of immunology, it has seen fast progress with many of its applications ready to be investigated in clinical settings.
New regulators of the tetracycline‐inducible gene expression system identified by chemical and genetic screens

The tetracycline repressor (tetR)‐regulated system is a widely used tool to specifically control gene expression in mammalian cells. Based on this system, we generated a human osteosarcoma cell line, which allows for the inducible expression of an EGFP fusion of the TAR DNA‐binding protein 43 (TDP‐43), which has been linked to neurodegenerative diseases. Consistent with previous findings, TDP‐43 overexpression led to the accumulation of aggregates and limited the viability of U2OS. Using this inducible system, we conducted a chemical screen with a library that included FDA‐approved drugs. While the primary screen identified several compounds that prevented TDP‐43 toxicity, further experiments revealed that these chemicals abrogated the doxycycline‐dependent TDP‐43 expression. This antagonistic effect was observed with both doxycycline and tetracycline, and in several Tet‐On cell lines expressing different genes, confirming the general effect of these compounds as inhibitors of the tetR system. Using the same cell line, a genome‐wide CRISPR/Cas9 screen identified epigenetic regulators such as the G9a methyltransferase and TRIM28 as potential modifiers of TDP‐43 toxicity. Yet again, further experiments revealed that G9a inhibition or TRIM28 loss prevented doxycycline‐dependent expression of TDP‐43. In summary, we have identified new chemical and genetic regulators of the tetR system, thereby raising awareness of the limitations of this approach to conduct chemical or genetic screening in mammalian cells.
Machine-learning-driven Architectural Selection of Adders and Multipliers in Logic Synthesis

Designing high-performance adders and multiplier components for diverse specifications and constraints is of practical concern. However, selecting the best architecture for adder or multiplier, which largely affects the performance of synthesized circuits, is difficult. To tackle this difficulty, a machine-learning-driven approach is proposed for automatic architectural selection of adders and multipliers. It trains a machine learning model for classification through learning a number of existing design schemes and their performance data. Experimental results show that the proposed approach based on a multi-perception neural network achieves as high as 94% prediction accuracy with negligible inference time. On a CPU server, the proposed approach runs about 4× faster than a brute-force approach trying four candidate architectures and consumes 10%~20% less runtime than the DesignWare datapath generator for obtaining the optimal adder/multiplier circuit. The adder (multiplier) generated with the proposed approach achieves performance metrics close to the optimal and has 1.6% (5.2%) less area and 2.2% (7.1%) more worst negative slack averagely than that generated with the DesignWare datapath generator. Our experiment also shows that the proposed approach is not sensitive to the size of training subset.