Miracle-dz/UniFAR-FTUs huggingface dataset:
Structural Aortic Regurgitation After Transcatheter Aortic Valve Implantation With Balloon-and Self-Expandable Prostheses

Results A total of 394 patients were included, 276 treated with MCV and 118 with ESV. Morethan-mild AR was significantly higher with MCV than with ESV (12.7% vs. 2.6%, p 1⁄4 0.002). This difference remained significant after propensity adjustment (adjusted odds ratio [OR]: 4.59, 95% confidence interval [CI]: 1.03 to 20.44). The occurrence of any degree of AR was also higher with MCV (71.6% vs. 56.9%, p 1⁄4 0.004). Device success was mainly influenced by the occurrence of AR and was consequently higher with ESV (95.8% vs. 86.6%, p 1⁄4 0.007), but this was not significant after propensity adjustment (adjusted OR: 0.34, 95% CI: 0.11 to 1.03, p 1⁄4 0.06). At 1 year, survival was comparable between both valve types (83.8% MCV vs. 88.2% ESV, p 1⁄4 0.42), but was significantly worse in patients with more-than-mild AR (69.8% vs. 87.4%, p 1⁄4 0.004) and in those with device failure (65.6% vs. 87.4%, p < 0.001).
Adaptive Finite-Horizon Group Estimation for Networked Navigation Systems with Remote Sensing Complementary Observations under Mixed LOS/NLOS Environments

Networked navigation system (NNS) enables a wealth of new applications where real-time estimation is essential. In this paper, an adaptive horizon estimator has been addressed to solve the navigational state estimation problem of NNS with the features of remote sensing complementary observations (RSOs) and mixed LOS/NLOS environments. In our approach, it is assumed that RSOs are the essential observations of the local processor but suffer from random transmission delay; a jump Markov system has been modeled with the switching parameters corresponding to LOS/NLOS errors. An adaptive finite-horizon group estimator (AFGE) has been proposed, where the horizon size can be adjusted in real time according to stochastic parameters and random delays. First, a delay-aware FIR (DFIR) estimator has been derived with observation reorganization and complementary fusion strategies. Second, an adaptive horizon group (AHG) policy has been proposed to manage the horizon size. The AFGE algorithm is thus realized by combining AHG policy and DFIR estimator. It is shown by a numerical example that the proposed AFGE has a more robust performance than the FIR estimator using constant optimal horizon size.
The Dearth of z ∼ 10 Galaxies in All HST Legacy Fields—The Rapid Evolution of the Galaxy Population in the First 500 Myr

We present an analysis of all prime HST legacy fields spanning >800 arcmin2 in the search for z ∼ 10 galaxy candidates and the study of their UV luminosity function (LF). In particular, we present new z ∼ 10 candidates selected from the full Hubble Frontier Field (HFF) data set. Despite the addition of these new fields, we find a low abundance of z ∼ 10 candidates with only nine reliable sources identified in all prime HST data sets that include the HUDF09/12, the HUDF/XDF, all of the CANDELS fields, and now the HFF survey. Based on this comprehensive search, we find that the UV luminosity function decreases by one order of magnitude from z ∼ 8 to z ∼ 10 over a four-magnitude range. This also implies a decrease of the cosmic star formation rate density by an order of magnitude within 170 Myr from z ∼ 8 to z ∼ 10. We show that this accelerated evolution compared to lower redshift can entirely be explained by the fast build up of the dark matter halo mass function at z > 8. Consequently, the predicted UV LFs from several models of galaxy formation are in good agreement with this observed trend, even though the measured UV LF lies at the low end of model predictions. The difference is generally still consistent within the Poisson and cosmic variance uncertainties. We discuss the implications of these results in light of the upcoming James Webb Space Telescope mission, which is poised to find much larger samples of z ∼ 10 galaxies as well as their progenitors at less than 400 Myr after the big bang.
GAM Nawwar L . essential oil Origanum majorana Free radical scavenging and antiacetylcholinesterase activities of

In the present study, Origanum majorana L. essential oil (EO) was analyzed by gas chromatography-mass spectrometry (GC-MS) and evaluated for free radical scavenging and anticholinesterase activities. GC-MS analysis revealed the presence of 4-terpineol (29.97%), g-terpinene (15.40%), trans-sabinene hydrate (10.93), a-terpinene (6.86%), 3-cycolohexene-1-1 methanal,a,a4-trimethyl-,(S)-(CAS) (6.54%), and sabinene (3.91%) as main constituents. Origanum majorana L. EO exhibited concentration-dependent inhibitory effects on 2,20-diphenylpicrylhydrazyl (DPPH ), hydroxyl radical, hydrogen peroxide, reducing power, and lipid peroxidation with IC50 values of 58.67, 67.11, 91.25, 78.67, and 68.75 mg/mL, respectively; while the IC50 values for the standard trolox were noted to be 23.95, 44.97, 51.30, 42.22, and 52.72 mg/mL, respectively. Interestingly, cholinesterase inhibitory activity was also found with IC50 values of 36.40 mg/mL. We can conclude that the marjoram EO has a significant potential to be used as a natural antioxidant and anti-AChE.
NCX 2 and NCX 3 expression in animal model of cerebral ischemia

Excitotoxicity and imbalance of sodium and calcium homeostasis trigger pathophysiologic processes in cerebral ischemia which can accelerate neuronal death. Neuroprotective role of cannabidiol (CBD), one of the main non-psychoactive phytocannabinoids of the cannabis plant, has attracted attention of many researchers in the neurodegenerative diseases studies. The present investigation was designed to determine whether cannabidiol can alleviate the severity of ischemic damages and if it is able to exert its anti-excitotoxic effects through sodium and calcium regulation. By using stereotaxic surgery, a guide cannula was implanted into the lateral ventricle. Cannabidiol (50, 100, and 200 ng/rat; i.c.v.) was administrated for 5 consecutive days. After pretreatment, the rats were subjected to 60 min of right middle cerebral artery occlusion (MCAO). After 24 h, neurological deficits score, infarct volume, brain edema, and blood–brain barrier (BBB) permeability in total of hemisphere, cortex, piriform cortex-amygdala, and striatum were assessed. The expression of Na+/Ca2+ exchangers
COMPETITIONS Toward the Robot Butler : the HUMABOT Challenge

The HUMABOT Challenge, the official robot competition for the 2014 IEEE Robotics and Automation Society (RAS) International Conference on Humanoid Robots (Humanoids 2014), was held during the conference in Madrid, Spain, 18–20 November. After running the Humanoids conference around the world for a long time, this was the first time that a competition was organized jointly with the event. This article highlights some of the logistic challenges and successes of the new competition.
Molecular identification and screening of mushrooms for antibacterial property against Pseudomonas aeruginosa and Staphylococcus aureus

In this study, 18 mushrooms were collected from Gandhi Krishi Vigyana Kendra (GKVK) campus, University of Agricultural Sciences, Bangalore (India) and identified by Internal Transcribed Spacer (ITS) region using National Centre for Biotechnology Information (NCBI) data base and screened for antibacterial property against two skin infection causing bacteria viz.,Pseudomonas aeruginosa and Staphylococcus aureus in dogs. Eleven mushrooms extract inhibited both the bacteria showing their antimicrobials as broad spectrum while inhibiting gram positive as well as gram negative bacteria. The highest zone of inhibition was recorded from the extract of Lyophyllum sp. The extract of two mushrooms viz., Phlebopus portentosus and Termitomyces sp. inhibited only P. aeruginosa, a gram negative bacterium and the extract of three mushrooms viz., Agaricus sp, Coprinellus disseminates and Agaricus blazei inhibited only S. aureus, a gram positive bacterium, suggesting spectral specificity of their antimicrobial compounds. However, the extracts of two mushrooms viz.,Macrocybe gigantea and Schizophyllum commune did not show inhibition of any of the pathogens. Hence, this study suggests that the occurrence of potential pharmaceuticals in mushrooms can be exploited for control of multidrug resistant bacteria.
Design and Analysis for Heat Transfer through Fin with Extensions

In this research, the heat transfer performance of fin is analyzed by design of fin with various extensions such as rectangular extension, trapezium extension, triangular extensions and circular segmental extensions. The heat transfer performance of fin with same geometry having various extensions and without extensions is compared. Near about ranging 5% to 13% more heat transfer can be achieved with these various extensions on fin as compare to same geometry of fin without these extensions. Fin with various extensions design with the help of software AutoCAD. Analysis of fin performance done through the software Autodesk ® Simulation Multiphysics. In this thermal analysis, temperature variations w.r. t. distance at which heat flow occur through the fin is analyzed. Extensions on the finned surfaces is used to increases the surface area of the fin in contact with the fluid flowing around it. So, as the surface area increase the more fluid contact to increase the rate of heat transfers from the base surface as compare to fin without the extensions provided to it. On comparison, rectangular extensions provide on fin gives the greatest heat transfer than that of other extensions having the same length and width attached to finned surface. The effectiveness of fin with rectangular extensions greater as compare to other extensions on fin.
An evaluation of the Wellington Regional Genuine Progress Index

There is widespread discontent with the gross domestic product (GDP) as a measure of progress for society. Alternative measures have been proposed, including the genuine progress indicator (GPI). This paper examines the changing institutional arrangements and attitudinal context in the recently developed Wellington region (New Zealand) GPI. We found an alignment between the GPI framework and the Local Government Act. Despite this fit, we identified challenges, including the need to revitalise public participation through deliberative techniques. It remains too early to judge whether the GPI initiative will launch a viable alternative to the GDP for the Wellington region.
Realizable higher-dimensional two-particle entanglements via multiport beam splitters

Multiport beam splitters are shown to be applicable in feasible optical realizations of higher-dimensional EPR correlations, and of tests of local realism involving measurements of nondichotomic variables. These multiports permit optical realizations of any unitary operator in Hilbert spaces of arbitrary finite dimension. Thus it is shown that one is by no means constrained to entangled spin systems, and to Stern-Gerlach apparatuses. In the analysis the concept of generalized Bell numbers is employed, which is more suitable than the standard set of spin eigenvalues. The results presented here move the discussion on entangled higher-than1 2
A Study on the Street Vendors of Kathmandu Municipality

Street vending is the most visible aspect of the informal sector, where thousands of people earn their living by selling goods on streets, sidewalks and other open public places. The number of street vendors is increasing day by day. Migrants from rural areas who do not possess the skill, knowledge and education to gain a better-paying job in the formal sector were found to settle for street vending. In most of cases, income generation is the secondary role for women whereas earning a living is the primary role for men. So access to income, savings, access and control over resources and freedom to use saved income for women were less significant than for men. The main expenditure of the vendors is on the basic needs of the family. Income earned through street vending has increased the financial independence and decision making power of women within the household. However, the majority of the women engaged in this sector were found to be overburdened with multiple responsibilities. Nevertheless, this study has shown that traditional attitudes about sex, class and caste based segregation of occupation and work role distribution seem to be changing. This is evident from the fact that the number of Brahmin and Chhetri women and men engaged in street vending is found to be increasing compared to the number of Newar men and women who are engaged in street vending. Traditionally, the main occupation of the Newar is business. The main reasons for the men to be engaged in street vending are to provide for the family and unemployment, whereas the main reason the women are engaged in street vending is that their spouse’s income is insufficient to provide for the basic needs of the family. The source of inspiration to pursue business for most of the women and men street vendors is themselves. Street vendors seem to be suffering from different health problems. Among them the most common are gastritis, headache, backbone pain, cold and fever. Street vendors also face expulsion from vending locations since there is no proper and systematic vending venue for
Prices, Consumption, and Dividends Over the Business Cycle: A Tale of Two Regimes

An economy in which investors know the true model and its parameters and filter the regime probability from aggregate consumption history has been empirically rejected. Hypothesizing that prices partly reflect investorsʼ belief about the regime, we infer beliefs from prices. The model fits well the moments of the market return, risk free rate, and price-dividend ratio. Consistent with the data, it implies higher mean and lower volatility of consumption and dividend growth rates, lower mean and volatility of the market return and equity premium, and higher mean of the price-dividend ratio in the first regime compared with the second one. The probability of recession in a year is 62:5% (23:7%) if the probability of being in the first regime at the beginning of the year is lower (higher) than 50%. The results support the hypothesis that investors employ a broader information set than just aggregate consumption history in forming their beliefs.
Strict Interpolation of a Smooth Function and Its First Derivative Using a Linearly-Trained Radial Basis Function Neural Network

We present a neural network, based on Gaussian functions, for interpolating a univariate function and its first derivative. The network is linearly trained, and constitutes a continuous piecewise approximation. It is based on the superposition of three standard Gaussian-based radial basis function networks. Analysis indicates that the network is a better approximation than the standard network.
Predicting Evolution in the Field : evolutionarily stable flowering size thresholds in the context of density dependent environmental fluctuations

1Department of Biology, Duke University, NC 27707, USA cjm29@duke.edu 2Department of Animal and Plant Sciences, University of Sheffield, Sheffield, S10 2TN, UK. M.Rees@sheffield.ac.uk 3CSIRO Entomology/CRC for Weed Management Systems, CSIRO European Laboratory, Campus International de Baillarguet,34980 Montferrier-sur-Lez, France. andy.sheppard@csiro-europe.org 4Department of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA, UK. pjg12@hermes.cam. ac.uk D.Z. Childs email: D.Childs@Sheffield.ac.uk K.E. Rose email: K.Rose@sheffield.ac.uk
Binding Correlated with Gene Expression Adipocytes Reveals Depot-Selective Primary Epididymal , Inguinal , and Brown in γ Proliferator-Activated Receptor Genome-Wide Profiling of Peroxisome

Published Ahead of Print 25 June 2012. 10.1128/MCB.00526-12. 2012, 32(17):3452. DOI: Mol. Cell. Biol. and Susanne Mandrup Nedergaard Nielsen, Søren F. Schmidt, Natasa Petrovic, Jan Majken S. Siersbæk, Anne Loft, Mads M. Aagaard, Ronni Binding Correlated with Gene Expression Adipocytes Reveals Depot-Selective Primary Epididymal, Inguinal, and Brown in γ Proliferator-Activated Receptor Genome-Wide Profiling of Peroxisome
An Integrated Forecasting DSS Architecture in Supply Chain Management

In a competing market environment, supply chain management (SCM) has been critical for companies to survive. Demand planning plays an important role in SCM, for it provides accurate demand forecasts which may achieve customer satisfaction by offering benefits such as low inventory level, short lead time, efficient resource allocation, and quick response. To obtain more accurate forecasts, this study presents a web-based DSS architecture and its forecasting core. The forecasting core, named Panel Function, contains three modules: Segmentation Module, Forecasting Module, and Coordination Module. Segmentation Module employs data mining technology to categorize customers with different characteristics into three segments: Loyal Customer Segment, Potential Customer Segment, and Switcher Segment. Based on the three segments, Forecasting Module employs different forecasting and analysis technologies to estimate an integrated forecast: time-series forecasting to capture the loyal customer demand trend, Bayesian inference to estimate the predicted value of switcher purchase quantity, and questionnaire analysis and brand choice models to unearth potential customers. An integration function then synthesizes the results from these three processes to obtain the integrated forecast. Coordination Module then takes this integrated forecast as the base of distribution planning, and provides a minimal system-wide total cost solution for all parties in the supply chain. As a whole, this DSS architecture is anticipated to provide an efficient mechanism for collaborative demand planning, and help create the maximum profit for the supply chain.
LOW-FREQUENCY IMAGE NOISE REMOVAL USINGWHITE NOISE FILTER Meisam Rakhshanfar

Image denoisers usually assume noise as white Gaussian. However, in capturing pipeline image noise often becomes spatially correlated due to in-camera processing in order to suppress the noise and increase the compression rate. Mostly, only high-frequency noise parts are suppressed since the image signal is more likely to appear in the low-frequency components. As a result, noise emerges as coarse grain which makes the white (all-pass) filter ineffective. Denoising of image approximation in coarse scale has the advantage of removing low-frequency noise, however, lack of spatial resolution degrades the image quality. This work presents a solution for a fast coarse-grain removal, especially when the resolution of the target display is lower than the captured image. The proposed solution utilizes existing white Gaussian noise filters to address spatially correlated noise employing pixel decoupling, local shrinkage, and soft thresholding. The results show that the proposed framework provides competitive results compared to other related approaches.
Copy MICROSATELLITE INSTABILITY IN EXTRACOLONIC GI MALIGNANCY 541 Lynch syndrome accounts for 2

T.0b013e3283653307 Summary Microsatellite instability (MSI) is a genetic feature of sporadic and familial cancers of multiple sites and is related to defective mismatch repair (MMR) protein function. Lynch syndrome (LS) is a familial form of MMR deficiency that may present with a spectrum of MSI positive cancers including gastrointestinal (GI) malignancies. The incidence of high level MSI (MSI-H) in colorectal carcinoma is well defined in both familial and sporadic cases and these tumours portend a better overall prognosis in colorectal carcinoma (CRC). There are certain morphological features that suggest MSI-H CRC and international guidelines have been established for the evaluation of MSI in CRC. The prevalence and morphological features of extracolonic GI MSI-H tumours are less well documented. Furthermore, it is unclear whether the guidelines for the assessment of MSI in CRC are appropriate for application to extracolonic GI malignancies. This review aims to summarise the recent literature on MSI in extracolonic LS-related GI tract malignancies with special attention to the assessment of the MMR system by evaluation of specific microsatellite markers and/or immunohistochemical evaluation of MMR protein expression. The reported prevalence of sporadic and LS-related MSI-H tumours along with their associated unique morphological patterns and related prognostic or therapeutic implications will be discussed.
Correction for “ 14-3-3 σ regulates B-cell homeostasis through stabilization of FOXO 1

IMMUNOLOGY Correction for “14-3-3σ regulates B-cell homeostasis through stabilization of FOXO1,” by Yu-Wen Su, Zhenyue Hao, Atsushi Hirao, Kazuo Yamamoto, Wen-Jye Lin, Ashley Young, Gordon S. Duncan, Hiroki Yoshida, Andrew Wakeham, Philipp A. Lang, Kiichi Murakami, Pamela Ohashi, and Tak W. Mak, which appeared in issue 4, January 25, 2011, of Proc Natl Acad Sci USA (108:1555–1560; first published January 4, 2011; 10.1073/pnas. 1017729108). The authors note that Heiko Hermeking should be added to the author line immediately following Kiichi Murakami, and Bert Vogelstein should be added to the author line immediately preceding Pamela Ohashi. Heiko Hermeking and Bert Vogelstein should be credited with contributing new reagents/ analytic tools. The online version has been corrected. The corrected author and affiliation lines and author contributions appear below.
Pain-Relief Effects of Aroma Touch Therapy with Citrus junos Oil Evaluated by Quantitative EEG Occipital Alpha-2 Rhythm Powers

Aroma touch therapy is widely used in clinical fields for alleviating pain-related symptoms; however, few studies have reported the pain-relief mechanisms. The present study aimed to elucidate the analgesic effects of aroma touch therapy with Citrus junos oil based on the quantitative evaluation of deep brain network (DBN) activity using electroencephalogram (EEG) occipital alpha-2 rhythm (10-13 Hz) powers. Experimental investigations were performed with 13 healthy volunteers using the cold pressor task for simulating chronic pain in three different sessions: a baseline session with no therapies, a control session with a touch therapy, and an aroma touch therapy. We have found for the first time that the interviewed pain ratings represented by Numeric Rating Scale (NRS) scores were strongly correlated with a DBN activity index, which was derived from the slow fluctuation components of occipital EEG alpha-2 rhythm powers. The correlation was characterized by a V-shaped curve in the DBN activity index versus the pain rating, i.e., the NRS score, which provided the complete analgesic states (NRS = 0) for some subjects under aroma touch therapy at an appropriate DBN activity index. Such analgesic states were not so strongly correlated with emotional valence. In conclusion, aroma touch therapy may directly modulate DBN activity so that pain-induced outcomes are minimized.