Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of Resting Heart Rate at 30 Days Following Transcatheter or Surgical Aortic Valve Replacement and Cardiovascular Outcomes: Insights from The PARTNER 2 Trial

ABSTRACT Background: Elevated resting heart rate (RHR) is associated with adverse cardiovascular outcomes in patients with untreated aortic valve stenosis (AS). However, the impact of RHR following transcatheter (TAVR) or surgical aortic valve replacement (SAVR) on cardiovascular outcomes is unknown. We therefore sought to determine the effect of RHR at 30 days after aortic valve replacement (AVR) on 2-year outcomes in patients with severe symptomatic AS. Methods: The study population consists of 3170 patients from the PARTNER 2 Trial and its embedded registries who underwent TAVR or SAVR for severe AS, and had available 12-lead electrocardiograms demonstrating sinus rhythm at 30 days post-procedure. Outcomes at 2 years were analyzed according to 30-day RHR modeled as a continuous variable and in groups (RHR ≥75 bpm and RHR <75 bpm). Results: By multivariable analysis, RHR ≥75 bpm at 30 days after AVR was an independent predictor of the composite endpoint of all-cause death, rehospitalization or stroke (hazard ratio [HR] 1.26, 95% confidence interval [CI], 1.05–1.52, p = 0.015) and rehospitalization (HR 1.42, 95% CI, 1.12–1.79, p = 0.004). Similarly, RHR modeled as a continuous variable (per 5 bpm) remained an independent predictor of all-cause death, rehospitalization or stroke (adjusted HR 1.07, 95% CI, 1.03–1.11, p = 0.0007), and rehospitalization (adjusted HR 1.09, 95% CI, 1.04–1.14, p = 0.0003) at 2 years. Conclusions: In patients with severe AS treated with TAVR or SAVR, resting heart rate at 30 days post-procedure was an independent predictor of the composite endpoint of all-cause death, rehospitalization or any stroke, and of rehospitalization at 2 years.
Using Clinical Decision Support Within the Electronic Health Record to Reduce Incorrect Prescribing for Acute Sinusitis.

Purpose Acute sinusitis has viral etiology in more than 90% of cases, but antibiotics are prescribed for more than 80% of adults in the United States. While applications of computer-assisted guidelines have been found effective in reducing inaccurate prescribing for acute respiratory infections, there is a paucity of research focused specifically on the utilization of electronic best practice alerts (BPA) in improving treatment for acute sinusitis. Methods This observational cohort study examined prescribing behavior for sinusitis at a single Federally Qualified Health Center 1 year prior and during the first year of implementation of a BPA in the electronic health record (EHR) reminding providers of the recommended treatment of sinusitis. The advisory included a link to national guidelines and a note template was installed to assist providers in documentation. The BPA appeared on the providers' screen when an ICD-9 code of acute or bacterial sinusitis was entered during the patient visit. Results After adjusting for select patient and provider factors, the computer-assisted guidelines effectively reduced the overall antibiotic prescribing among these patients by 31% (relative risk: 0.69, 95% confidence interval: 0.51-0.95) and reduced incorrect prescribing from 88.5% to 78.7% (P=0.02). Conclusions Clinical reminders within the EHR can be an effective tool to reduce inappropriate antibiotic use and improve providers' decisions regarding the correct antibiotic choices for patients with acute sinusitis.
A Hybrid Approach to Develop and Integrate Chatbot in Health Informatics Systems

: In this paper, we develop a chatbot that seeks free-form natural language queries by its users for blood and related services such as list of blood banks, live blood stock, blood donation camps etc. with one or more parameters as search criteria. The queries can be both Frequently Asked Questions (FAQs) and data driven including location based services. The uniqueness of this chatbot lies in the fact that its architecture provides it ﬂexibility to evolve to encompass more domains and services without having any impact on existing services. Moreover, with approximate keyword initialization, the proposed chatbot can smartly infer from incomplete or incorrect queries by the users as well as has the ability to learn abbreviations. The bot achieves this by leveraging state-of-the-art deep learning and natural language understanding algorithms at the back-end. Speciﬁcally, this bot uses a hierarchical approach for parsing queries. At ﬁrst level, it parses the query into intents i.e. FAQ or data driven. If the classiﬁed intent is a FAQ, chatbot to respond while, if it is amongst many of the citizen centric queries, it drills down through the query to identify the entities such as city etc. along with the type of the service and returns the users with the required details.
The transmission spectrum of the potentially rocky planet L 98-59 c

We present observations of the 1 . 35 ± 0 . 07 Earth-radius planet L 98-59 c using Wide Field Camera 3 on the Hubble Space Telescope. L 98-59 is a nearby (10.6 pc), bright (H=7.4 mag), M3V star that harbors three small, transiting planets. As one of the closest known transiting multi-planet systems, L 98-59 oﬀers one of the best opportunities to probe and compare the atmospheres of rocky planets that formed in the same stellar environment. We measured the transmission spectrum of L 98-59 c during a single transit, with the extracted spectrum showing marginal evidence for wavelength-dependent transit depth variations which would indicate the presence of an atmosphere. Forward-modeling was used to constrain possible atmospheric compositions of the planet based on the shape of the transmission spectrum. While L98-59 is a fairly quiet star, we have seen evidence for stellar activity, and therefore we cannot rule out a scenario where the source of the signal originates with inhomogeneities on the host-star surface. While intriguing, our results are inconclusive and additional data is needed to verify any atmospheric signal. Fortunately, additional data will soon be collected from both HST and JWST. Should this result be conﬁrmed with additional data, L 98-59 c would be the ﬁrst planet smaller than 2 Earth-radii with a detected atmosphere, and among the ﬁrst
Towards an Ambient Support System for Continence Management in Nursing Homes: An Exploratory Study

Time consuming and costly, continence care management has become one of the main care demands in nursing homes with potential inadequacy negatively impacting residents’ quality of life. While engineering efforts in this area are increasing, these mainly focus on wearable innovations. To support continence care in nursing homes in an unobtrusive manner, we developed an ambient sensor system to continuously monitor incontinence events, e.g., saturated incontinence materials or leakages. In an exploratory study in two nursing homes, we evaluated an early prototype of the sensor system and built annotated data sets. Implemented annotation devices included a smart sensor mat, a toilet timing predicting device, and manual data entry of continence care by care personnel. From our analysis of the preliminary study results based on the first two residents, we learned how challenging the ambient monitoring and annotation of incontinence events is. On the basis of the outcomes, we provide suggestions for further research of ambient sensor systems supporting continence care.
Expressions of Caring as Lived by Nursing Home Staff, Residents, and Families

Nursing as caring (Boykin & Schoenhofer, 1993, 2001) was utilized as the framework for design of a model of healthcare delivery in a nursing home that is intentionally grounded in caring. The article presents themes emerging from a qualitative analysis of interview data in which participants were asked what was most important when caring for a resident or family member and to share an experience that best represented caring. Suggestions are offered for creating a model of culture change in nursing homes that honors and values expressions of caring as lived by staff, families, and residents.
Risk factors affecting postoperative pulmonary function in congenital diaphragmatic hernia

Purpose It is well known that congenital diaphragmatic hernia (CDH) in infants impacts pulmonary function rehabilitation after surgery. However, the risk factors of postoperative pulmonary function are still unclear. In this research, we analyzed the potential risk factors of postoperative pulmonary function in CDH patients in order to improve the clinical management of CDH patients. Methods Thirty-three cases CDH infants followed were enrolled from November 2016 to September 2018. Clinical data were reviewed. Tidal breathing pulmonary function testing was performed after surgery. Correlation between pulmonary function and clinical characteristics was evaluated using multivariate analysis of variance. Results Pulmonary dysfunction was detected in 87.9% patients (29 of 33). The defect size was found to be significantly larger in patients with obstructed and mixed ventilatory disorders (P = 0.001). Diagnosis of gestational age (GA) was also significantly earlier compared to restrictive ventilatory disorders (P = 0.001). Larger defect size, and earlier prenatal diagnosis of GA were detected in severe obstructive ventilatory disorders (P = 0.007, P = 0.001, retrospectively). Conclusion Most patients had various degrees of pulmonary dysfunction after surgery. Patients with larger defect size and earlier diagnosis time might be vulnerable to severe obstructive and mixed ventilatory disorders.
Bacterial Endotoxin Induces Oxidative Stress and Reduces Milk Protein Expression and Hypoxia in the Mouse Mammary Gland

The aim of this study was to investigate the mechanisms underlying the reduced milk production during mastitis. We hypothesized that bacterial endotoxin induces hypoxia, oxidative stress, and cell apoptosis while inhibiting milk gene expression in the mammary gland. To test this hypothesis, the left and right sides of the 4th pair of mouse mammary glands were alternatively injected with either lipopolysaccharide (LPS, E. coli 055: B5, 100 μL of 0.2 mg/mL) or sterile PBS through the teat meatus 3 days postpartum. At 10.5 and 22.5 h postinjection, pimonidazole HCl, a hypoxyprobe, was injected intraperitoneally. At 12 or 24 h after the LPS injection, the 4th glands were individually collected (n = 8) and analyzed. LPS treatment induced mammary inflammation at both 12 and 24 h but promoted cell apoptosis only at 12 h. Consistently, H2O2 content was increased at 12 h (P < 0.01), but dropped dramatically at 24 h (P < 0.01) in the LPS-treated gland. Nevertheless, the total antioxidative capacity in tissue tended to be decreased by LPS at both 12 and 24 h (P = 0.07 and 0.06, respectively). In agreement with these findings, LPS increased or tended to increase the mRNA expression of antioxidative genes Nqo1 at 12 h (P = 0.05) and SLC7A11 at 24 h (P = 0.08). In addition, LPS inhibited mammary expression of Csn2 and Lalba across time and protein expression of Csn1s1 at 24 h (P < 0.05). Furthermore, hypoxyprobe staining intensity was greater in the alveoli of the PBS-treated gland than the LPS-treated gland at both 12 and 24 h, demonstrating a rise in oxygen tension by LPS treatment. In summary, our observations indicated that while intramammary LPS challenge incurs inflammation, it induces oxidative stress, increases cell apoptosis and oxygen tension, and differentially inhibits the milk protein expression in the mammary gland.
Atypical Clinical Course in a Patient with Acute Carotid Artery Dissection

Dissection is a term that is often used to describe the separation of the intima layer of the artery from the media layer and, more rarely, the separation of the media layer from the adventitia layer. Carotid artery dissection is associated with intramural accumulation of blood. In dissection cases in whom intramural hematoma develops, the mechanism of ischemic stroke is often related to thromboembolism and, more rarely, to hemodynamic failure (4). Intravenous thrombolytic therapy (IVT) is an effective and reliable treatment for acute ischemic stroke.
A Responsive Web Application for the Improvement of Healthy Habits in the Child Population

: The World Health Organization declared childhood obesity as a global epidemic, stressing the need for urgent action in order to face this serious public-health problem. This paper presents a pilot program based on a technological solution to improve the nutrition and physical activity habits in children. The solution is a multiplatform application that can be accessed both from computers and mobile devices. A study of current, similar solutions was carried out and a web application was designed and built, combining information on healthy nutrition and physical activity habits with the functionalities of an online social network. This application was used to carry out a pilot intervention with children from the first and second years of Compulsory Secondary Education (CSE) at a school in Spain. After the pilot program, feedback was received from the users, obtaining valuable information for introducing a number of improvements that will be incorporated into a future program.
Reframing conservation physiology to be more inclusive, integrative, relevant and forward-looking: reflections and a horizon scan

Abstract Applying physiological tools, knowledge and concepts to understand conservation problems (i.e. conservation physiology) has become commonplace and confers an ability to understand mechanistic processes, develop predictive models and identify cause-and-effect relationships. Conservation physiology is making contributions to conservation solutions; the number of ‘success stories’ is growing, but there remain unexplored opportunities for which conservation physiology shows immense promise and has the potential to contribute to major advances in protecting and restoring biodiversity. Here, we consider how conservation physiology has evolved with a focus on reframing the discipline to be more inclusive and integrative. Using a ‘horizon scan’, we further explore ways in which conservation physiology can be more relevant to pressing conservation issues of today (e.g. addressing the Sustainable Development Goals; delivering science to support the UN Decade on Ecosystem Restoration), as well as more forward-looking to inform emerging issues and policies for tomorrow. Our horizon scan provides evidence that, as the discipline of conservation physiology continues to mature, it provides a wealth of opportunities to promote integration, inclusivity and forward-thinking goals that contribute to achieving conservation gains. To advance environmental management and ecosystem restoration, we need to ensure that the underlying science (such as that generated by conservation physiology) is relevant with accompanying messaging that is straightforward and accessible to end users.
Associations between smoking cessation and depression among the population in Northwest China

Background: Many studies have indicated a relationship between smoking cessation and a history of depression. However, few studies have examined the association between smoking cessation and current depression and even fewer evidence come from mainland China. The aim of this study is to determine the prevalence of smoking quitters, the correlates of successful smoking cessation, and its relationship with depressive symptoms in Northwest China. Methods: A total of 7,644 subjects who met the study’s entry criteria were randomly selected from the urban areas of three provinces in Northwest China and interviewed using standardized assessment tools, including basic characteristics of households and detailed information on family members. All respondents provided informed consent. Results: people with depression symptom have a more than 1.5-fold risk of abstinence from smoking than those without depression (OR=1.54; 95% CI, 1.2 to 1.9) and the likelihood ratio test for two models reach statistical significance (x2=13.2, p<0.001). Smoking quitters have a more than 1.5-fold risk of having depressive symptoms than current smokers (OR=1.54; 95% CI, 1.2 to 1.9) and the likelihood ratio test for two models is also statistically significant (x2=6449.85, p<0.001). Conclusions: The prevalence of smoking quitters in urban areas of Northwest China is very low. After controlling certain confounders, smoking cessation is associated with current depressive symptoms. More rigorous surveys are needed to elucidate the barriers to smoking cessation in China. Government bodies in China should implement appropriate strategies and execute effective measures to mitigate its harmful consequences.
Psychosocial factors affecting African Americans in alcohol dependency

SCHOOL OF SOCIAL WORK MOMTAHAN, M. M. B.S. & M.S.W. TEHRAN COLLEGE OF INSURANCE, 1977 MB.A. ATLAlsTTA UNIVERSITY, 1980 PSYCHOSOCIAL FACTORS AFFECTING AFRICAN AMERICANS IN ALCOHOL DEPENDENCY Advisor; Richard Lyle, Ph.D. Dissertation dated July, 2003 This study is based on a comprehensive review ofpsychosocial factors in alcohol dependency presented by 214 African American and white patients in Grady Memorial Hospital. The purpose of this study was to extend and elaborate descriptive research of psychosocial differences to create and sustain the appropriate prevention and treatment strategies. Therefore, this research relies on Biopsychoecological Integrative Contextual Model that not only permits competing explanations of the etiology and epidemiology but also embarks on prevention and treatment plans. Prevention Research Institute (PRI), George L. Engel, Jerrold S. Maxmen, Nicholas G. Ward and others have presentedmodels of drinking vulnerabilities that have utilized the above model. As an alternative, this study has confirmed the validity of this model, and structured the theoretical and empirical approaches based on its framework.
扩增片段长度多态性（Amplified Fragment Length Polymorphism，AFLP）基本原理和特点

扩增片段长度多态性（AFLP）是建立在RFLP基础上的选择性聚合酶链反应（Polymerase Chain Reaction．PCR），它的基本原理是对基因组DNA进行限制性内切酶酶切，将人工合成的特定双链接头连在这些片段的两端，形成一个带接头的特异片段，用这些特异片段为扩增反应模板，通过接头序列和PCR引物3’一端选择性碱基的识别，
Growth and Survival of Listeria monocytogenes in Market Cheeses Stored at 4 to 30°C.

Forty-nine market cheeses representing 24 types and 28 brands were purchased from local supermarkets. Pieces of cheeses of approximately 1.5 × 0.5 cm were surface inoculated with log10 3.95 to 4.36 cells of a Listeria monocytogenes pool made up of five strains (Scott A, V7, RM-1, VPH1, VPH2) and placed in petri dishes. After wrapping with cellophane, the dishes were stored at 4, 8, and 30°C for up to 36 d. Of the cheeses, 36.7% supported growth equivalent to a mean inoculum increase of 1.4 log10 (range 0.21 to 3.58) in at least one storage temperature. They included soft Hispanic type (Queso Fresco, Panela Ranchero, pH 6.2-6.6), Ricotta (pH 5.9-6.1), Teleme (pH 5.9), Brie (pH 7.2-7.7), Camembert (pH 7.3), and cottage (pH 4.9-5.1) cheeses. Ricotta was the best and cottage the worst substrate for growth. Cheeses not supporting Listeria growth but causing gradual death at all temperatures include: Cotija (Hispanic hard cheese), cream, blue, Tillamook, Cracker Barrel, Monterey Jack, Swiss, Cheddar, Colby, string, Provolone, Muenster, Feta, and Kasseri with values of pH 4.3-5.6, process (American, Monterey Jack, Piedmont, pH 5.7-6.4), and Limburger (pH 7.2) cheeses. A highly significant (P<0.005) correlation of Listeria growth with cheese pH values >5.5 and absence of starter cultures during the cheese manufacturing was observed. Overall, the study demonstrated that cross-contamination of certain cheeses with L. monocytogenes originating from raw foods (meat, poultry, fish, vegetables), after opening of packages, may lead to significant growth of the pathogen during refrigerated storage.
Chronic diabetic peripheral neuropathic pain: psychometric properties of pain and physical function outcome measures

Abstract Background: Diabetic peripheral neuropathy (DPN) not only produces severe pain, tingling, and numbness sensation in the involved limbs, but also limits physical function due to loss of sensation. There are no recommended methods for clinical situations to measure these signs and symptoms. Studies with high methodological quality use the modified Brief Pain Inventory for Diabetic Peripheral Neuropathic pain (mBPI-DPN) scale and the short form Screening of Activity Limitations and Safety Awareness (sSALSA) scale for measuring these symptoms in DPN population. In order to capture a real change in the variables of interest, the psychometric properties of that measure should be within acceptable limits. As these two measures were not assessed for all of the psychometric properties, there was a need for further evaluation. Methods: Data were collected (n = 38 patients) in a longitudinal cohort study. Test–retest reliability (0–4 weeks) and Responsiveness- Minimal Clinically Important Difference (MCID) (0–12 weeks) were calculated between two sessions. Convergent validity was assessed (between mBPI-DPN pain interference and sSALSA scale). Results: Both measures demonstrated acceptable test–retest reliability (mBPI-DPN scale: ICC = 0.61, SEM = 12.92; the sSALSA scale: ICC = 0.81, SEM = 4.88) and convergent validity (Spearman’s correlation coefficient r = 0.62). The computational methods used in different methodologies to calculate MCID for the mBPI-DPN and the sSALSA scale were varied, hence the magnitude of derived MCID scores also varied. Conclusions: Our study have provided evidence to add to the scientific basis surrounding the use of mBPI-DPN and sSALSA scales in DPN population, but standardization of these measures in a larger population is required
Sexual transmitted diseases and control of reproduction in biology textbooks: a comparative analysis in 15 countries

We present a comparative analysis in textbooks of different 15 countries on the topic “Human Reproduction and Sex Education” by using a specific grid of analysis. The focus is on two subtopics associated to pupils’ development of responsible behaviour: the control of reproduction (e.g. choice of contraception) and the Sexually Transmitted Diseases (STDs). AIDS is presented in all textbooks analysed. Some countries, but not all, give also information about other STDs. We analysed condom images and how textbooks refer to the way of using it. Results show differences not only between countries but also between publishers of the same country. Acknowledgements This work has been done with the help of an European research project (‘Biology, Health and Environmental Education for better Citizenship’: "Biohead-Citizen" CIT2-CT2004-506015), STREP of the priority 7 of FP6. Thanks for the collective work done inside this project. The authors particularly thank the other participants who gathered data or coordinated this process concerning the topic "Health Education" in the textbooks of their respective countries: Franz Bogner, Christina Geier & Britta Oerke (Germany), Daniel Favre & Valérie de la Forest (France), Adriana Valente, Daniela Luzi & Silvia Caravita (Italy), Nicos Valanides, Olympia Nisiforou & Petroulla Tzortzi (Cyprus), Tago Sarapuu & Kersti Kaplinski (Estonia), Iman Khalil & Jaber Yolla (Lebanon), Sami Abdelli & Mondher Abrougui (Tunisia), Attila Varga & Dániel Horváth (Hungary), Jurga Turcinaviciene & Grita Skujiene (Lithuania), Desiree Scicluna Bugeja & Paul Pace (Malta), Adrienne Kozan (Romania), Farida Khammar (Algeria), Taoufic Abboudi & Boujemaa Agorram (Morocco), Valdiodio Ndiaye (Senegal), Anna-Liisa Rauma & Salla Mielonen (Finland). Special thanks to Franz Bogner for English.