Miracle-dz/UniFAR-FTUs huggingface dataset:
HOspital care versus TELemonitoring in high-risk pregnancy (HOTEL): study protocol for a multicentre non-inferiority randomised controlled trial

Introduction Pregnant women faced with complications of pregnancy often require long-term hospital admission for maternal and/or fetal monitoring. Antenatal admissions cause a burden to patients as well as hospital resources and costs. A telemonitoring platform connected to wireless cardiotocography (CTG) and automated blood pressure (BP) devices can be used for telemonitoring in pregnancy. Home telemonitoring might improve autonomy and reduce admissions and thus costs. The aim of this study is to compare the effects on patient safety, satisfaction and cost-effectiveness of hospital care versus telemonitoring (HOTEL) as an obstetric care strategy in high-risk pregnancies requiring daily monitoring. Methods and analysis The HOTEL trial is an ongoing multicentre randomised controlled clinical trial with a non-inferiority design. Eligible pregnant women are >26+0 weeks of singleton gestation requiring monitoring because of pre-eclampsia (hypertension with proteinuria), fetal growth restriction, preterm rupture of membranes without contractions, recurrent reduced fetal movements or an intrauterine fetal death in a previous pregnancy. Randomisation takes place between traditional hospitalisation (planned n=208) versus telemonitoring (planned n=208) until delivery. Telemonitoring at home is facilitated with Sense4Baby CTG devices, Microlife BP monitor and daily telephone calls with an obstetric healthcare professional as well as weekly hospital visits. Primary outcome is a composite of adverse perinatal outcome, defined as perinatal mortality, 5 min Apgar <7 or arterial cord blood pH <7.05, maternal morbidity (eclampsia, HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome, thromboembolic event), neonatal intensive care admission and caesarean section rate. Patient satisfaction and preference of care will be assessed using validated questionnaires. We will perform an economic analysis. Outcomes will be analysed according to the intention to treat principle. Ethics and dissemination The study protocol was approved by the Ethics Committee of the Utrecht University Medical Center and the boards of all six participating centres. Trial results will be submitted to peer-reviewed journals. Trial registration number NTR6076.
Effects of Pharmacotherapy Treatment on Patient-Reported Outcomes in a Narcolepsy and Idiopathic Hypersomnia Cohort.

STUDY OBJECTIVE We aimed to evaluate the association between patient-reported outcomes (PROs) and treatment regimen/standardized dose (STD), a measure of drug burden, in patients with narcolepsy type 1 (NT1)/type 2 (NT2) and idiopathic hypersomnia (IH). METHODS Patients age 18 years or older with NT1/NT2 and IH with baseline and ≥ 6-month follow-up during 2008-2010 were included. Changes in PROs (Epworth Sleepiness Scale [ESS], Fatigue Severity Scale [FSS], Patient Health Questionnaire 9 [PHQ-9], total sleep time [TST]) by diagnosis, treatment regimen (monotherapy versus polytherapy, sodium oxybate [SO] use), and STD were assessed by t tests and univariable/multivariable linear regressions, adjusting for patient characteristics. RESULTS A total of 92 patients (26 [28.3%] NT1, 27 [29.3%] NT2, 39 [42.4%] IH) were included (age 43.8 ± 14.8 years; 66 [71.7%] female). Baseline PROs suggested excessive daytime sleepiness (ESS 14.2 ± 5.2 [74% patients > 10]), significant fatigue (FSS 47.5 ± 12.9), and mild depression (PHQ-9 9.0 [4.0, 14.0] [49.4% ≥ 10]). At follow-up, ESS and PHQ-9 improved significantly overall and within diagnostic, monotherapy/polytherapy, and SO use groups (all P < .01). FSS improved significantly overall (P = .016), but improvements were not significant for IH, monotherapy, polytherapy, and non-SO using groups. In multivariable models, PRO changes were not significantly different between groups, but baseline STD was associated with worsening PHQ-9 across PHQ-9 change models, and ESS worsened with increasing STD at follow-up (P = .056). CONCLUSIONS Significant improvements in sleep-related PROs were seen with pharmacotherapy use, regardless of diagnosis or treatment type, highlighting the importance of individualized prescribing decisions for this population.
Evolving flocking in embodied agents based on local and global application of Reynolds’ rules

In large scale systems of embodied agents, such as robot swarms, the ability to flock is essential in many tasks. However, the conditions necessary to artificially evolve self-organised flocking behaviours remain unknown. In this paper, we study and demonstrate how evolutionary techniques can be used to synthesise flocking behaviours, in particular, how fitness functions should be designed to evolve high-performing controllers. We start by considering Reynolds’ seminal work on flocking, the boids model, and design three components of a fitness function that are directly based on his three local rules to enforce local separation, cohesion and alignment. Results show that embedding Reynolds’ rules in the fitness function can lead to the successful evolution of flocking behaviours. However, only local, fragmented flocking behaviours tend to evolve when fitness scores are based on the individuals’ conformity to Reynolds’ rules. We therefore modify the components of the fitness function so that they consider the entire group of agents simultaneously, and find that the resulting behaviours lead to global flocking. Furthermore, the results show that alignment need not be explicitly rewarded to successfully evolve flocking. Our study thus represents a significant step towards the use of evolutionary techniques to synthesise collective behaviours for tasks in which embodied agents need to move as a single, cohesive group.
Biopreservation as a potential hurdle for Bacillus cereus growth in fresh cheese.

This study aimed to evaluate the possible inhibitory effect of natural lactic acid bacteria on the growth of 2 Bacillus cereus strains. First, we evaluated the behavior of spores of B. cereus GPe2 and D43 when inoculated before cheesemaking using pasteurized or raw milk; no statistical differences were observed between cheese produced with the 2 types of milk. Then, lactic acid bacteria (LAB) were isolated from cheese at the last sampling time, identified, and tested in vitro for their antagonistic activity and organic acid production by using an HPLC method, showing antimicrobial potential. The LAB that produced larger inhibition halos (>9 mm) against B. cereus strains (LAB 3, 6, 9, 10: Lactococcus lactis ssp. lactis; LAB 7: Lactococcus lactis ssp. cremoris) were selected to produce a LAB mixture for subsequent tests. Spores of B. cereus GPe2 and D43 were inoculated in pasteurized milk before cheesemaking with or without addition of the LAB mixture at a high dosage. Bacillus cereus grew more slowly when LAB were added to the dairy matrix (with differences from 2.36 to 2.66 log cfu/g in B. cereus GPe2 and D43 growth).
Adding Increased Energy or Activity to Criterion (A) of the DSM-5 Definition of Hypomania and Mania: Effect on the Diagnoses of 907 Patients From the Bipolar Collaborative Network.

OBJECTIVE According to DSM-IV, criterion (A) for diagnosing a hypomanic/manic episode is mood change (ie, elevated, expansive, or irritable mood). Criterion (A) was redefined in DSM-5, adding increased energy or activity in addition to mood change. We sought to investigate the effect of adding increased energy or activity to criterion (A) for the diagnosis of hypomania/mania and, thus, bipolar disorder. METHODS This analysis of prospectively collected data from the Bipolar Collaborative Network (1995-2002) includes 907 DSM-IV-TR-diagnosed bipolar outpatients (14,306 visits). The Young Mania Rating Scale (YMRS) was administered monthly and used to define DSM-IV and DSM-5 criterion (A) fulfillment during a hypomanic/manic visit. RESULTS Patients were adults (median age = 40; IQR, 33-49), and over half (56%) were women. Median number of contributed visits was 10 (IQR, 4-23). Applying DSM-5 criterion (A) reduced the number of patients experiencing a hypomanic/manic visit by 34%, compared to DSM-IV. Visits fulfilling DSM-5 criterion (A) had higher odds of experiencing elevated levels of all other mania symptoms, compared to fulfilling DSM-IV criterion (A) only. Association between individual symptoms was strongest with mood elevation and energy or activity (OR [95% CL] = 8.65, [7.91, 9.47]). CONCLUSIONS The 34% reduction in the number of patients being diagnosed with a hypomanic/manic visit shows that the impact of applying DSM-5 criterion (A) is substantial. Fewer hypomanic/manic episodes may be diagnosed by the stricter DSM-5 criterion (A), but the episodes diagnosed are likely to be more severe. The DSM-5 criteria may in general prevent overdiagnosis of bipolar disorder but possibly at the cost of underdiagnosing hypomanic/manic episodes.
Analysis of HC selection for MCTS in simultaneous move games

Hannan consistency, or no external regret, is a key concept for learning in games. An action selection algorithm is Hannan consistent (HC), if its performance is eventually as good as selecting the best fixed action in hindsight. If both players in a zero-sum normal form game use a Hannan consistent algorithm, their average behavior converges to a Nash equilibrium of the game. A similar result is known about extensive form games, but the played strategies need to be Hannan consistent with respect to counterfactual values, which are often difficult to obtain. We study zero-sum extensive form games with simultaneous moves, but otherwise perfect information. These games generalize normal form games and they are a special case of extensive form games. We study whether applying HC algorithms in each decision point of a these games directly to the observed payoffs leads to convergence to a Nash equilibrium. This learning process corresponds to a class of Monte Carlo Tree Search algorithms, which are popular for playing simultaneous move games, but do not have any known performance guarantees. We show that using HC algorithms directly on the observed payoffs is not sufficient to guarantee the convergence. With an additional averaging over joint actions, the convergence is guaranteed, but empirically slower. We further define an additional property of HC algorithms, which is sufficient to guarantee the convergence without the averaging and we empirically show that commonly used HC algorithms have this property.
Ubc9 Interacts with and SUMOylates the TCR Adaptor SLP-76 for NFAT Transcription in T Cells

Key Points Ubc9 interacts with and SUMOylates the immune adaptor SLP-76 in T cells. Synergy of SLP-76–Ubc9 on IL-2 transcription is SLP-76 SUMOylation dependent. SLP-76 SUMOylation is required for Ubc9-NFAT complex assembly for IL-2 transcription. Visual Abstract Although the immune adaptor SH2 domain containing leukocyte phosphoprotein of 76 kDa (SLP-76) integrates and propagates the TCR signaling, the regulation of SLP-76 during the TCR signaling is incompletely studied. In this article, we report that SLP-76 interacts with the small ubiquitin-like modifier (SUMO) E2 conjugase Ubc9 and is a substrate for Ubc9-mediated SUMOylation in human and mouse T cells. TCR stimulation promotes SLP-76–Ubc9 binding, accompanied by an increase in SLP-76 SUMOylation. Ubc9 binds to the extreme C terminus of SLP-76 spanning residues 516–533 and SUMOylates SLP-76 at two conserved residues K266 and K284. In addition, SLP-76 and Ubc9 synergizes to augment the TCR-mediated IL-2 transcription by NFAT in a manner dependent of SUMOylation of SLP-76. Moreover, although not affecting the TCR proximal signaling events, the Ubc9-mediated SUMOylation of SLP-76 is required for TCR-induced assembly of Ubc9-NFAT complex for IL-2 transcription. Together, these results suggest that Ubc9 modulates the function of SLP-76 in T cell activation both by direct interaction and by SUMOylation of SLP-76 and that the Ubc9–SLP-76 module acts as a novel regulatory complex in the control of T cell activation.
Transcription Factor and miRNA Interplays Can Manifest the Survival of ccRCC Patients

Clear cell renal cell carcinoma (ccRCC) still remains a higher mortality rate in worldwide. Obtaining promising biomakers is very crucial for improving the diagnosis and prognosis of ccRCC patients. Herein, we firstly identified eight potentially prognostic miRNAs (hsa-miR-144-5p, hsa-miR-223-3p, hsa-miR-365b-3p, hsa-miR-3613-5p, hsa-miR-9-5p, hsa-miR-183-5p, hsa-miR-335-3p, hsa-miR-1269a). Secondly, we found that a signature containing these eight miRNAs showed obviously superior to a single miRNA in the prognostic effect and credibility for predicting the survival of ccRCC patients. Thirdly, we discovered that twenty-two transcription factors (TFs) interact with these eight miRNAs, and a signature combining nine TFs (TFAP2A, KLF5, IRF1, RUNX1, RARA, GATA3, IKZF1, POU2F2, and FOXM1) could promote the prognosis of ccRCC patients. Finally, we further identified eleven genes (hsa-miR-365b-3p, hsa-miR-223-3p, hsa-miR-1269a, hsa-miR-144-5p, hsa-miR-183-5p, hsa-miR-335-3p, TFAP2A, KLF5, IRF1, MYC, IKZF1) that could combine as a signature to improve the prognosis effect of ccRCC patients, which distinctly outperformed the eight-miRNA signature and the nine-TF signature. Overall, we identified several new prognosis factors for ccRCC, and revealed a potential mechanism that TFs and miRNAs interplay cooperatively or oppositely regulate a certain number of tumor suppressors, driver genes, and oncogenes to facilitate the survival of ccRCC patients.
The Science of Child Sexual Abuse

Child sexual abuse (CSA) involving sexual contact between an adult and a child has been reported by approximately 20% of women and 5 to 10% of men worldwide. A history of CSA leads to serious mental and physical health problems, substance abuse, and criminality in adulthood. Scientific study of CSA is currently underfunded, obscured by contentious forensic controversy, and fragmented by discipline. From public health, economic, ethical, and scientific perspectives, the authors of this Policy Forum recommend interdisciplinary consensus panels and increased intellectual investment in CSA research, prevention, intervention, and education.
THE EFFECT OF REGULAR SPORTS TRAINING OF DIFFERENT MODE ON SERUM LIPID PROFILE OF THE INDIAN ATHLETES

Objectives: To obtain an insight into the influence exerted upon serum lipid profile by physical training in different specialties of the Indian athletes. Methods: Three group of subjects were studied i.e. walkers (n = 11), boxers (n = 11) and sedentary subjects (n = 11). Triglycerides (TG), Cholesterol/ HDL Cholesterol Ratio (C/H Ratio), Total Cholesterol (TC) and its fractions – HDL, LDL and VLDL Cholesterols were determined in serum by an enzymatic/colorimetric method. Results: Significant difference of C/H Ratio, LDL and of HDL-cholesterol was found in walkers as compared to other groups. Conclusion: Our findings suggest that endurance directed sports training activity has more favorable effects on serum lipid profile.
Novel Compound Heterozygous Mutations in TTI2 Cause Syndromic Intellectual Disability in a Chinese Family

Telomere maintenance 2 (TELO2)–interacting protein 2 (TTI2) interacts with TTI1 and TELO2 to form the Triple T complex, which is required for various cellular processes, including the double-strand DNA break response, nonsense-mediated mRNA decay, and telomerase assembly. Herein, we identified compound heterozygous mutations in TTI2 using whole-exome sequencing (WES) in a Chinese family with a recessive inheritance pattern of syndromic intellectual disability. The patients displayed intellectual disability, aggressive and self-injurious behaviors, facial dysmorphic features, microcephaly, and skeletal anomalies. In addition, one patient showed cerebral white matter abnormality. Maternal novel indel mutation resulted in a premature termination codon and nonsense-mediated mRNA decay. Paternal reported c.1100C > T mutation changed the highly conserved proline to leucine that located in the DUF2454 domain. Immunoblotting experiments showed significantly decreased TTI2, TTI1, and TELO2 in the patients’ lymphocytes. These results indicated that TTI2 loss-of-function mutations might cause an autosomal-recessive syndromic intellectual disability by affecting the Triple T complex. Our report expands the genetic causes of syndromic intellectual disability in the Chinese population.
ENDOTHELIN-1 (ET-1) AND CYCLOSPORINE-A (CSA) STIMULATE STEROID SECRETION FROM RAT ADRENAL CORTEX: EVIDENCE THAT BOTH ET-1 AND CSA SECRETAGOGUE EFFECTS ARE MEDIATED BY THE B SUBTYPE OF ET-1 RECEPTORS

The effects of endothelin—1 (ET-1) and cyclosporine-A (CSA) on adrenal steroidogenesis were investigated in virro, using rat capsule-zona glomerulosa (ZG) and zona fasciculata (ZF) preparations. ET-1 concentration-dependently raised aldosterone (ALDO) and corticosterone (B) outputs by capsule-ZG and ZF preparations, respectively. Maximal effective concentrations was 10‘8M. Two specific antagonists of subtypes A and B of ET-1 receptors (BQ-123 and BQ-788, respectively) were employed. BQ-788 impaired the secretory response of our adrenal preparations to 1O‘3M ET-l, while BQ-123 was ineffective. The maximal effective concentration of BQ-788 was 10-7 M. CSA (l0“8 M) elicited marked ALDO and B secretagogue effects, which were of the same order of magnitude of those evoked by 10""3M ET-1 and were abolished by 10‘7M BQ-788. Autoradiography showed 1251-ET-1 binding in both ZG and ZF. BQ-788 decreased labeling in the ZG and virtually eliminated it in the ZF; CSA effects were analogous to those of BQ-788, as also demonstrated by quantitative densitometry. In light of these findings, the following conclusions can be drawn: 1) ET-1 stimulates in the rat not only the secretion of ALDO from ZG, but also that of B from ZF; 2) the adrenocortical secretagogue effect of ET-1 is exclusively mediated by the B subtype of ET-1 receptors; and 3) CSA, at relatively low concentrations, exerts a stimulatory action on adrenal steroidogenesis, probably acting as an agonist of ET-1 receptors of type B. Endothelins (ET) are a family of peptides secreted by vascular endothelium, with a potent vasoconstrictor and pressor activity (for review, see 17, 30, 48). ET act via two main subtypes of receptors, Abbreviations. ‘ ACTH, adrenocorticotropic hormone; ALDO, aldosterone; ANOVA, analysis of variance; B, corticosterone; BSA, bovine serum albumin; CSA, cyclosporine-A; EDRF, endothelium-derived relaxing factor; ET, endothelins; ET(A) and ET(B), subtypes A and B of endothelin receptors; HPLC, high performance liquid chromatography; HSA, human serum albumin; KRGB, Krebs—Ringer bicarbonate buffer-glucose; RIA, radioimmunoassay; ZF, zona fasciculata; ZG, zona glomerulosa named ET(A) and ET(B), that are mainly expressed in vascular smooth-muscle cells and endothelial cells, respectively (for review, see 18, 49). ET-1 is well-known to enhance in vivo and in vitro aldosterone (ALDO) secretion from adrenal zona glomerulosa (ZG) of several mammalian species (8, 10, 11, 34, 35, 45, 54), including the rat (18, 19, 31, 40, 41). Scanty findings, requiring to be confirmed, also indicate that ET-1 stimulates cortisol and corticosterone (B) secretion from dispersed human and rat zona fasciculata (ZF) cells (5, 19). Accordingly, autoradiography demonstrates 1251-ET-1 binding in the whole adrenal cortex, with a preferential localization in the ZG (12, 23, 24, 26, 38).
>LOGIT MODELS FOR REPEATED ORDERED CATEGORICAL RESPONSE DATA

Logit models are presented for repeated observations on an ordinal categorical response variable. The models describe how the marginal distribution of the response depends on values of explanatory variables. Primary attention is given to a cumulative logit model that generalizes models proposed by McCullagh (1977, 1980). Also diocussed are an a.ljruoentcategories logit model that is equivalent to a loglinear model for marginal response probabilities, and a mean response model. The models are illustrated with an example in which a drug and placebo are compared with respect to treatment of insomnia problems. When the covanates are categorical. a weighted least squares fit for each type of model can be obtained using PROC CATMOD.
Evaluation of Ferritin and Nitric Oxide Levels in Breast Cancer

Breast carcinoma is one of the commonest malignancies in females. It is curable, if detected, at an early stage. Levels of serum ferritin and nitric oxide are found raised in various cancers including breast carcinoma. These parameters are sufficiently interlinked to be used as markers for breast cancer. In this study, the levels of ferritin and nitric oxide were estimated in 30 patients of early stage (stage I and II) and 30 patients of advanced breast cancer (stge III and IV). These levels were compared with 30 healthy females as controls. Serum ferritin and nitric oxide were found to be raised (p<0.001) in all breast cancer patients as compared to controls. The rise in their levels was significantly more in advanced stage as compared to early stage carcinoma (p<0.001). Treatment had a curative effect on these parameters also as shown by a decrease in their levels in both the groups. Thus, estimation of ferritin and nitric oxide may aid in diagnosis, assessment of severity and monitoring of breast cancer patients though results will be highly reliable in conjunction with other tumor markers.
Quality Assurance of RDB2RDF Mappings

Since datasets in the Web of Data stem from many different sources, ranging from automatic extraction processes to extensively curated knowledge bases, their quality also varies. Thus, significant research efforts were made to measure and improve the quality of Linked Open Data. Nevertheless, those approaches suffer from two shortcomings: First, most quality metrics are insufficiently formalised to allow an unambiguous implementation which is required to base decision on them. Second, they do not take the creation process of RDF data into account. A popular extraction approach is the mapping of relational databases to RDF (RDB2RDF). RDB2RDF techniques allow to create large amounts of RDF data with only few mapping definitions. This also means that single errors in an RDB2RDF mapping can affect a considerable portion of the generated data. In this paper we present an approach to assess RDB2RDF mappings also considering the actual process of the RDB to RDF transformation. This allows to detect and fix problems at an earlier stage before resulting in potentially thousands of data quality issues in published data. We propose a formal model and methodology for the evaluation of the RDB2RDF mapping quality and introduce actual metrics. We evaluate our assessment framework by applying our reference implementation on different real world RDB2RDF mappings.