Miracle-dz/UniFAR-FTUs huggingface dataset:
The Block Object Storage Service (bossDB): A Cloud-Native Approach for Petascale Neuroscience Discovery

Large volumetric neuroimaging datasets have grown in size over the past ten years from gigabytes to terabytes, with petascale data becoming available and more common over the next few years. Current approaches to store and analyze these emerging datasets are insufficient in their ability to scale in both cost-effectiveness and performance. Additionally, enabling large-scale processing and annotation is critical as these data grow too large for manual inspection. We provide a new cloud-native managed service for large and multi-modal experiments, with support for data ingest, storage, visualization, and sharing through a RESTful Application Programming Interface (API) and web-based user interface. Our project is open source and can be easily and cost-effectively used for a variety of modalities and applications.
Developing Islamic crowdfunding website platform for startup companies in Indonesia

Purpose This study aims to develop an Islamic crowdfunding model based on a website platform for startup companies. Design/methodology/approach Apart from reviewing related literature, specifically focus group discussion with 16 CEO of startup companies, in-depth interview with two crowdfunding provider, Fiqh expert and technology platform expert for the development of an Islamic crowdfunding website platform for startup companies. Findings The concept of Islamic crowdfunding is recommended as a funding solution for small and medium-sized enterprises and startup companies. Therefore, it was deemed crucial for this study to develop an Islamic crowdfunding model based on a website platform as a form of innovative acceleration to provide alternative funding for a startup company, which subsequently expands to a growing and sustainable business. Furthermore, the use of a website platform for the operation of a crowdfunding mechanism is deemed as an effective means to link cross-geographical investors with the startup company owners in Indonesia, specifically East Java. Practical implications Islamic crowdfunding website platform can be the solution for startup companies to obtain capital funds while startup companies are not able to provide collateral to attain financial assistance and experience problems. Expectedly, the government should provide legality, regulation, licensing and socialization matters pertaining to crowdfunding to obtain legal legality from the country. Originality/value There is still no research to develop the Islamic crowdfunding model using a website platform. This study was expected to provide essential insights on the effective development of an Islamic crowdfunding website platform integrated with startup companies, investors and Sharia committee.
Association of daily and time-segmented physical activity and sedentary behaviour with mental health of school children and adolescents from rural Northeastern Ontario, Canada

Physical activity (PA) and sedentary behaviour (SED) have been linked to the mental health of children and adolescents, yet the timing of behaviours may play a role in this relationship and clarifying this could inform interventions. We explored cross-sectional associations of PA and SED in varying time segments throughout the school day with the mental health of school-aged children and adolescents from rural Northeastern Ontario, Canada. A total of 161 students (56% female, M = 10.3 years old) wore accelerometers for 8 days (7 nights) and completed a self-report survey (parent reported for children younger than 11). Mental health was measured using the Strengths and Difficulties Questionnaire. Accelerometer-measured SED, light PA (LPA), and moderate and vigorous PA (MVPA) were estimated in the time-segments before school (06:00–08:44), school time (08:45–15:04), after school (15:05–16:59), and evenings (17:00–21:59). Associations were tested with multilevel linear regressions while adjusting for confounding factors. Students spent 72.6 min in MVPA, 209.0 min in LPA, and 621.0 min in SED per day. Daily SED was associated with less conduct problems (β = −0.27, p < 0.05). Evening LPA was inversely associated with hyperactivity (β = −1.45, p < 0.05), while SED was associated with hyperactivity and with peer problems before school (β = 1.70 and β = 1.01, respectively, p < 0.05), and during school (β = −0.83 and β = −0.57, respectively, p < 0.05). No associations were observed for MVPA, emotional symptoms, or prosocial behaviour. In conclusion, displacing SED with LPA in some specific periods of the day may benefit the mental health of students; taking this into account could strengthen interventions.
Integrating transcriptomics and network analysis-based multiplexed drug repurposing to screen drug candidates for M2 macrophage-associated castration-resistant prostate cancer bone metastases

Metastatic castration-resistant prostate cancer (CRPC) has long been considered to be associated with patient mortality. Among metastatic organs, bone is the most common metastatic site, with more than 90% of advanced patients developing bone metastases (BMs) before 24 months of death. Although patients were recommended to use bone-targeted drugs represented by bisphosphonates to treat BMs of CRPC, there was no significant improvement in patient survival. In addition, the use of immunotherapy and androgen deprivation therapy is limited due to the immunosuppressed state and resistance to antiandrogen agents in patients with bone metastases. Therefore, it is still essential to develop a safe and effective therapeutic schedule for CRPC patients with BMs. To this end, we propose a multiplex drug repurposing scheme targeting differences in patient immune cell composition. The identified drug candidates were ranked from the perspective of M2 macrophages by integrating transcriptome and network-based analysis. Meanwhile, computational chemistry and clinical trials were used to generate a comprehensive drug candidate list for the BMs of CRPC by drug redundancy structure filtering. In addition to docetaxel, which has been approved for clinical trials, the list includes norethindrone, testosterone, menthol and foretinib. This study provides a new scheme for BMs of CRPC from the perspective of M2 macrophages. It is undeniable that this multiplex drug repurposing scheme specifically for immune cell-related bone metastases can be used for drug screening of any immune-related disease, helping clinicians find promising therapeutic schedules more quickly, and providing reference information for drug R&D and clinical trials.
The effect of personality traits on employees’ annual salaries in Chinese startups

Personality is a relatively regular habit of a person. It exerts a specific influence on personal behavior and the corresponding results. At the same time, personality can provide a certain degree of explanation for the differences among individuals in behavior and the related consequences. Economic differences are one of the discrepancies that exist among individuals. In order to explore the quantitative relationship between personality and individual income, this study takes 376 active employees of Chinese startups as the primary research objects. Additionally, considering the simplification and convenience of the survey, the annual salary investigated by this study is the pre-tax income of active startup employees. It uses quantitative methods to analyze the relationship between their personality traits and annual salary. Unlike the measures used in previous studies, this study employed the HEXACO-60 Inventory created by Ashton and Lee to investigate employees’ personality traits. Compared to the Big Five model, HEXACO (Honesty-Humility, Emotionality, eXtraversion, Consciousness, Open to Experience, and Agreeableness) adds a new dimension to evaluate personality traits, called Honesty-Humility (H-H). H-H did not appear in previous studies related to personality and individual income. Therefore, there is no reference to the relationship between H-H and personal earnings. Considering that the content of H-H is highly consistent with the components of inter locus of control and the core spirit advocated by the Confucian culture, which influences Chinese people profoundly, this paper proposes a bold hypothesis, that is, H-H has a positive correlation with employees’ annual salaries. Meanwhile, other corresponding hypotheses for the correlation between the other personality traits in HEXACO and employees’ annual salaries are proposed. After that, the above hypotheses are tested with the help of correlation analysis. Then, the following conclusions can be quickly drawn. Consciousness, eXtraversion, Open to Experience, and Honesty-Humility positively correlate with employees’ annual salaries. In comparison, Emotionality and Agreeableness negatively correlate with employees’ annual salaries.
Evaluation of deformable image registration using diffeomorphic transformation models for three-dimensional temporal subtraction of chest tomography images

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Identify the immune characteristics and immunotherapy value of CD93 in the pan-cancer based on the public data sets

CD93 is a transmembrane receptor that is mainly expressed on endothelial cells. A recent study found that upregulated CD93 in tumor vessels is essential for tumor angiogenesis in several cancers. However, the underlying mechanisms are largely unexplored. Our present research systematically analyzed the characteristics of CD93 in tumor immunotherapy among 33 cancers. CD93 levels and co-expression of CD93 on cancer and stromal cells were detected using public databases and multiple immunofluorescence staining. The Kaplan-Meier (KM) analysis identified the predictive role of CD93 in these cancer types. The survival differences between CD93 mutants and WT, CNV groups, and methylation were also investigated. The immune landscape of CD93 in the tumor microenvironment was analyzed using the SangerBox, TIMER 2.0, and single-cell sequencing. The immunotherapy value of CD93 was predicted through public databases. CD93 mRNA and protein levels differed significantly between cancer samples and adjacent control tissues in multiply cancer types. CD93 mRNA expression associated with patient prognosis in many cancers. The correlation of CD93 levels with mutational status of other gene in these cancers was also analyzed. CD93 levels significantly positively related to three scores (immune, stromal, and extimate), immune infiltrates, immune checkpoints, and neoantigen expression. Additionally, single-cell sequencing revealed that CD93 is predominantly co-expressed on tumor and stromal cells, such as endothelial cells, cancer-associated fibroblasts (CAFs), neutrophils, T cells, macrophages, M1 and M2 macrophages. Several immune-related signaling pathways were enriched based on CD93 expression, including immune cells activation and migration, focal adhesion, leukocyte transendothelial migration, oxidative phosphorylation, and complement. Multiple immunofluorescence staining displayed the relationship between CD93 expression and CD8, CD68, and CD163 in these cancers. Finally, the treatment response of CD93 in many immunotherapy cohorts and sensitive small molecules was predicted from the public datasets. CD93 expression is closely associated with clinical prognosis and immune infiltrates in a variety of tumors. Targeting CD93-related signaling pathways in the tumor microenvironment may be a novel therapeutic strategy for tumor immunotherapy.
GAMING THE SYSTEM: TEACHING SOCIOECONOMIC INEQUITY THROUGH ROLEPLAYING AND DISCUSSION USING AN EDUCATIONAL BOARD GAME

Gamification is a popular pedagogical tool for increasing student engagement and teaching threshold concepts. Our paper describes the development and assessment of an educational board game. The Landlord Game uses roleplaying and productive negativity to help students develop a deeper understanding of socioeconomic inequality. This game purposely places players in an intense, often frustrating struggle for socioeconomic mobility. This aims to help them build empathy and challenge received understandings of the relationship between wealth and poverty. The game is a multiplayer, turn-based board game that reimagines the popular board game Monopoly TM by problematizing its reductive economic model and resisting bootstrap theories, such as Social Darwinism. Through qualitative and formal assessment of the gameplay in different undergraduate courses using pre-and post-attitudinal surveys and discussion, we found that The Landlord Game helped students engage with and reevaluate their understanding of the systemic inequities inherent to contemporary capitalism.
Cooperative POMDPs for human-Robot joint activities

Objectif de cette these est le developpent de methodes de planification pour la resolution de tâches jointes homme-robot dans des espaces publiques. Dans les espaces publiques, les utilisateurs qui cooperent avec le robot peuvent facilement se distraire et abandonner la tâche jointe. Cette these se focalise donc sur les defis poses par l’incertitude et imprevisibilite d’une cooperation avec un humain. La these decrit l’etat de l’art sur la cooperation homme-robot dans la robotique de service, et sur les modeles de planification. Elle presente ensuite une nouvelle approche theorique, basee sur les processus decisionnels de Markov partiellement observables, qui permet de garantir la cooperation de l’humain tout au long de la tâche, de facon flexible, robuste et rapide. La these introduit une structure hierarchique qui separe l’aspect cooperatif d’une activite jointe de la tâche en soi. L’approche a ete appliquee dans un scenario reel, un robot guide dans un centre commercial. La these presente les experiences effectuees pour mesurer la qualite de l’approche proposee, ainsi que les experiences avec le robot reel.
Modelling the Effect of Website Quality and Perceived Information Value on Tourist Satisfaction: A Survey of Hotels in Phuket, Thailand

This paper presents the investigation of the effect of website quality on tourist satisfaction. It focuses on an issue of the hotel industry in Phuket Province, Thailand: Does the website quality of hotels affect the relationship between the perceived value and tourist satisfaction? The results indicate that only the service quality aspect of website quality was affect positively associated with tourist satisfaction, whereas the service quality and information quality of hotel websites were not affect associated with the perceived information value. The perceived information value was affect strongly positively associated with tourist satisfaction.
Polyurethane foams with 1,3,5-triazine ring, boron and silicon

The method of obtaining polyurethane foams with 1,3,5-triazine ring and silicon and boron atoms, based on two oligoetherols, the one, synthesized from melamine diborate and propylene carbonate and the second, obtained from metasilicic acid, glycidol and ethylene carbonate, was elaborated. The physical properties of polyurethane foams were tested depending on composition of oligoetherol substrates mixture used. Obtained polyurethane foams have high compression strength and enhanced thermal resistance in comparison to classic rigid polyurethane foams. Long-term thermal exposure at 150–175°C results in increase of compression strength and reducing in flammability. The polyurethane foams exposed per month at 150°C show increase of oxygen index within 24.4–27.6, i.e. they are self-extinguishing. When polyurethane foams are exposed at 175°C, the oxygen index rise into 46.5–48.0, and the materials become non-flammable.
Tectonic Controls on Taupo Volcanic Zone Geothermal Expression: Insights From Te Mihi, Wairakei Geothermal Field

Information on structure, stress, and their interrelationship is essential for understanding structurally controlled geothermal permeability. Active fault mapping, borehole image analysis, and well testing in the Te Mihi geothermal area, New Zealand, allows us to refine structural and fluid flow architecture of this resource. The Te Mihi area is structurally complex, comprising a set of NW dipping master faults containing pervasive SE dipping antithetic and splay structures in their hanging walls. These faults are also intersected by E‐W striking faults. A localized, N‐S striking structural trend is also observed at Te Mihi. In consideration with Global Navigation Satellite System velocity vectors, both active NE‐SW and E‐W striking faults create biaxial extension at Te Mihi, though the observed NE‐SW SHmax direction suggests that contemporary extension is NW‐SE dominated. Stress field perturbations coincide with structural complexities like fault splays and intersections and/or proximity to recently active E‐W and NE‐SW striking structures. Borehole fluid flow at Te Mihi is concentrated at NW dipping master fault intersections, travel time fractures on acoustic image logs, halo fractures on resistivity image logs, NE‐SW and E‐W striking fractures, intervals of high fracture density, and spatial concentrations of wide aperture fractures and recently active NE‐SW and E‐W striking fractures. This study suggests Te Mihi geothermal expression results from biaxial extension evident from active structural trend intersections and the predominance of NE‐SW and E‐W striking structures within permeable well zones. Biaxial extension is therefore an important control on crustal fluid flow within the Taupo Volcanic Zone and thus geothermal resource delineation.
A network view of human immune system and virus-human interaction

The immune system is highly networked and complex, which is continuously changing as encountering old and new pathogens. However, reductionism-based researches do not give a systematic understanding of the molecular mechanism of the immune response and viral pathogenesis. Here, we present HUMPPI-2022, a high-quality human protein-protein interaction (PPI) network, containing > 11,000 protein-coding genes with > 78,000 interactions. The network topology and functional characteristics analyses of the immune-related genes (IRGs) reveal that IRGs are mostly located in the center of the network and link genes of diverse biological processes, which may reflect the gene pleiotropy phenomenon. Moreover, the virus-human interactions reveal that pan-viral targets are mostly hubs, located in the center of the network and enriched in fundamental biological processes, but not for coronavirus. Finally, gene age effect was analyzed from the view of the host network for IRGs and virally-targeted genes (VTGs) during evolution, with IRGs gradually became hubs and integrated into host network through bridging functionally differentiated modules. Briefly, HUMPPI-2022 serves as a valuable resource for gaining a better understanding of the composition and evolution of human immune system, as well as the pathogenesis of viruses.
Consultant and Public Client Collaborations in the Infrastructure Industry

A prevailing problem in the construction industry is inefficient processes and increased project costs, in combination with a work culture characterized by conflicts and distrust. Extended collaboration means that involved parties agreed to work together in a structured and coordinated way towards a common goal. Through extended collaboration, projects are perceived to be more effective, result in lower project costs and generate a better end product. Previous research has primarily studied the building construction industry and the relationship between client and contractor. Extended collaboration in infrastructure projects is less studied, nor is the relationship between consultant and client. The aim of the study is therefore to investigate consultant and public client collaborations in the infrastructure industry, in order to achieve more efficient collaboration processes. The study is conducted at Rejlers and includes Trafikverket and Trafikkontoret in Gothenburg. The data collection consists of 17 semistructured interviews with consultants and clients, represented on the Swedish infrastructure market. The qualitative research method provides opportunity for an indepth understanding and reflection of experiences from the industry, including the respondents' different views on collaboration. The study shows that there is a positive attitude towards extended collaboration, however, the term is intuitive and creates confusion. The experiences of extended collaboration that currently takes place display many challenges, for instance, a lack of purpose and implementation of the concept. The study therefore suggests that the meaning of collaboration should be specified and a division of two different concepts would be appropriate. The collaboration-culture should describe attitudes and values, in order to change the prevailing culture in the industry. The collaboration-process should describe a formalized process with an explicit working method for how collaboration should be implemented, with the starting point "why collaboration should take place". ISO-44001 is a proposal for such a process. The development and implementation of the concepts should be conducted by the actors in the industry, both internally within the own organisation and externally between organizations.
Effect of environmental tax reform on corporate green technology innovation

China has recently taken several measures to counter the environmental pollution caused by the crude model of past economic development. Among them, taxation has proved especially efficient. We take the Environmental Protection Tax Law, implemented on 1 January 2018, as a quasi-natural experiment to study the effect of environmental protection tax reform on corporate green technology innovation. We analyze data on Shanghai and Shenzhen A-share listed companies for 2013–2020. We find that raising the tax levy significantly promotes green innovation among enterprises. The promotion effect is more significant in state-owned enterprises, heavily polluting enterprises, and the eastern region. The findings of the full sample and subsample still hold after replacing the explanatory variables for stability testing. The effects vary significantly based on property rights, geography, and level of industry pollution. Nevertheless, environmental tax reform is an effective initiative toward environmental protection, even if the complexity of China’s economic environment reveals some variation in the effects of this policy reform. We make suggestions to address these differences for future studies.