Miracle-dz/UniFAR-FTUs huggingface dataset:
78-LB: Efficacy and Safety of Tirzepatide, a Dual GIP/GLP-1 Receptor Agonist, Compared with Insulin Degludec in Patients with Type 2 Diabetes (SURPASS-3)

Tirzepatide (TZP) is a novel dual GIP/GLP-1 receptor agonist under development for the treatment of type 2 diabetes (T2D). The efficacy and safety of TZP vs. titrated insulin degludec (IDeg) were assessed in insulin-naive patients with T2D inadequately controlled on metformin with/without SGLT-2i. In this open-label, 52-week, Phase 3 study, 1444 patients with T2D were randomized (1:1:1:1) to once-weekly TZP (5, 10, 15 mg) or once-daily IDeg (mean baseline [BL] age, 57.4 years; T2D duration, 8.4 years; HbA1c, 8.17%; BMI, 33.5 kg/m2; 32% on SGLT-2i). The primary efficacy endpoint was mean change in HbA1c from BL to Week 52. Secondary efficacy endpoints included mean change in fasting serum glucose (FSG) and body weight (BW) and proportion of subjects achieving HbA1c and BW goals. All TZP doses were superior to IDeg in mean change from BL in HbA1c and BW, and in the proportion of patients achieving all HbA1c and BW goals at Week 52 (Table). Among patients taking TZP 15 mg, 48.4% achieved HbA1c Disclosure B. Ludvik: Advisory Panel; Self; AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Research Support; Self; Amgen Inc., Eli Lilly and Company, Novo Nordisk, Speaker’s Bureau; Self; MSD Corporation. F. Giorgino: Consultant; Self; AstraZeneca, Boehringer Ingelheim International GmbH, Lilly Diabetes, Novo Nordisk, Roche Diabetes Care, Sanofi, Research Support; Self; Lilly Diabetes, Roche Diabetes Care. E. Jodar: Other Relationship; Self; AstraZeneca, Lilly Diabetes, Mundipharma International, Novo Nordisk, Speaker’s Bureau; Self; Boehringer Ingelheim International GmbH. J. Frias: Consultant; Self; 89bio, Inc., Altimmune, Axcella Health Inc., Boehringer Ingelheim Pharmaceuticals, Inc., Eli Lilly and Company, Gilead Sciences, Inc., Intercept Pharmaceuticals, Inc., Merck & Co., Inc., Novo Nordisk, Pfizer Inc., Sanofi, Research Support; Self; AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Bristol-Myers Squibb Company, CymaBay Therapeutics, Eli Lilly and Company, Intercept Pharmaceuticals, Inc., Janssen Pharmaceuticals, Inc., Madrigal Pharmaceuticals, Inc., Merck & Co., Inc., Novartis Pharmaceuticals Corporation, Novo Nordisk, Pfizer Inc., Sanofi, Speaker’s Bureau; Self; Merck & Co., Inc., Sanofi. L. Fernandez lando: Employee; Self; Eli Lilly and Company, Stock/Shareholder; Self; Eli Lilly and Company. K. Brown: Employee; Self; Eli Lilly and Company. R. Bray: None. A. Rodriguez: Employee; Self; Eli Lilly and Company, Stock/Shareholder; Self; Eli Lilly and Company. Funding Eli Lilly and Company
Phylogenetic Diversity and Antioxidant Activity of Selected Fungi From Ethno Medicinal Plants & Soil

Endophytic fungi are prolific generators of bioactive metabolites with natural antioxidant properties that have a range of potential uses. In the present work, the antioxidant activity and phylogenetic diversity of endophytic fungi obtained from semi-arid terrestrial plants and the fungi obtained from the mangrove soil samples is investigated. The fungal isolates were identified by employing morphological features and phylogenetic characterization by internal transcribed spacer (ITS) sequences. Six taxonomic orders of Ascomycota associated with nine genera were identified, these being Diaporthales, Eurotiales, Hypocreales, Onygenales, Pleosporales and Xylariales. The antioxidant activity methanolic extracts of the fungal isolates were determined using modified 2,2’-diphenyl-1-picrylhydrazyl (DPPH) and 2,2’-azino-bis (3-ethylbenzothiazoline-6-sulphonicacid) (ABTS) methods. Among the fungal isolates, Aspergillus sp. AREF023 and Fusarium sp. AREF014, obtained from different parts of Datura metel, displayed the highest level of radical inhibition (80.76% and 70.62% respectively). GC/-MS analysis of the active isolates confirmed the presence of known antioxidant phenolic compounds, including 2-tert-Butyl-5-hydroxymethyl-5-methyl-[1,3]dioxolan-4-one and Phenol, 2,5-bis(1,1-dimethylethyl), in the their crude extracts. Our findings suggest that fungal isolates from D. metel can be a sustainable resource for natural antioxidants.
Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity

Inducing senescence in cancer cells is emerging as a new therapeutic strategy. In order to find ways to enhance senescence induction by palbociclib, a CDK4/6 inhibitor approved for treatment of metastatic breast cancer, we performed functional genetic screens in palbociclib-resistant cells. Using this approach, we found that loss of CDK2 results in strong senescence induction in palbociclib-treated cells. Treatment with the CDK2 inhibitor indisulam, which phenocopies genetic CDK2 inactivation, led to sustained senescence induction when combined with palbociclib in various cell lines and lung cancer xenografts. Treating cells with indisulam led to downregulation of cyclin H, which prevented CDK2 activation. Combined treatment with palbociclib and indisulam induced a senescence program and sensitized cells to senolytic therapy. Our data indicate that inhibition of CDK2 through indisulam treatment can enhance senescence induction by CDK4/6 inhibition.
The power to gaslight

Gaslighting is a dysfunctional pattern of relating that destabilizes an individual’s sense of reality. Adopting a communication perspective, this study examined the relationship between gaslighting and interpersonal power dynamics. Participants (N = 298) recalled a disagreement with a dating partner and provided measures of dependence power and their experience of gaslighting. Results were counter-theoretical, suggesting a curvilinear relationship between gaslighting and power. Specifically, individuals with low and high levels of power reported greater gaslighting than those with moderate power. Results suggest that tacit control attempts differ from overt control attempts in how they (re)produce relational hierarchy. The study underscores the importance of understanding relationship contexts in studying dysfunctional interpersonal dynamics.
Microstructure and optical performance of In2S3 thin films grown by chemical bath deposition

ABSTRACT The In2S3 thin films were deposited by chemical bath deposition at different processing parameters. The In2S3 films were well crystallized when grown at pH values in the range of 1.6–2.0. With increase of the sulfide ion concentration and deposition temperature, the formation and growth rates of β-In2S3 crystals improve. Too high sulfide ion concentration and deposition temperature can induce decomposition of In2S3 crystals. When grown at pH value of 1.8, nIn:nS ratio of 1:4 and deposition temperature of 80°C, the In2S3 film can achieve highly crystallized structure, high transmittance of over 80% and proper energy gap value of 2.74 eV.
Wintertime In Situ Cloud Microphysical Properties of Mixed‐Phase Clouds Over the Southern Ocean

In situ observations made over 20 flights during three Austral winters (June to October 2013–2015) were analyzed to characterize the cloud microphysical properties and natural variability of mid‐latitude shallow convective clouds over the Southern Ocean (SO), with a focus on pristine conditions and the mixed‐phase temperature range (MPTR, 0°C to −31°C). Liquid, mixed‐phase, and ice cloud fractions were observed 39%, 44%, and 17% of the time, respectively, under various meteorological settings. Liquid phase clouds were typically characterized by low droplet number concentrations and the common presence of drizzle. Supercooled liquid water was prevalent in the MPTR, while freezing of supercooled raindrops likely formed the primary ice nucleation mechanism in these shallow clouds. Ice particles of various habits were present in the mature/maturing convective cloud cells, suggesting the operation of multiple particle growth regimes. Increased ice particle concentrations (exceeding 100 L−1), well in excess of the expected ice nuclei concentrations, were measured at temperature warmer than approximately −12°C, signaling the operation of secondary ice production mechanisms. However, these cloud segments were spatiotemporally inhomogeneous, suggesting the chaotic and turbulent nature of the secondary ice‐forming processes. Accurately representing these processes in global models, while necessary, is likely a challenge. Our analysis also found marked inconsistencies between several satellite‐based cloud phase products that have underpinned recent developments of model parameterization frameworks. Understanding and addressing these inconsistencies are critical toward improving the representation of SO clouds and their radiative properties in climate models.
Bridging the digital divide: the smart TV as a platform for digital literacy among the elderly

ABSTRACT More and more countries have become greying societies along with the burgeoning of digital devices. The older generation suffers from a sharp digital divide. Although the information infrastructure is fully developed, the elderly, not having grown up with it, tend to lack digital literacy and hold less intention to learn to use digital technologies. In the past, it was cable TV which pervaded the market and because of its long history of development became indispensable in the lives of the elderly. Recently, the maturity of Smart TV, provides us with an appropriate digital learning tool to assist seniors in Taiwan to improve their digital literacy. This is done utilising a digital remote control, designed to be a mixture of new and old technologies that offers seniors a high degree of familiarity. The study explore the effects of technology anxiety, digital feedback, and familiar technological skills on the adoption of digital devices by the elderly. In addition, a learning strategy compatible with the existing living environment of the elderly is proposed. The findings and recommendations for an effective approach to this problem are discussed as well as limitations and future research directions.
The Development of Mobile Communications in 5G and 6G

: Extensive use of communication and information technologies has led to the introduction of different generations of mobile communications. The first to fourth generations (1G-4G) of communication are fully recognized in the world, the fifth generation (5G) is gradually being implemented in different countries, and studies and research on the sixth generation (6G) are in the early stages. The development and deployment of the new generation of mobile communication will have a significant influence on the development and presentation of mobile communications. In this paper, a brief review of the development trend of mobile communication generations with a focus on 5G and especially 6G has been done with respect to the visions, technologies, challenges and issues related to these two generations.
Incorporating compressor station multiple failure modes in risk evaluation of electricity-gas integrated energy systems

Multiple failure modes of gas compressor stations have not been modeled in the risk evaluation of electricity-gas integrated energy system (EGIES). This paper presents a method to incorporate the multiple failure modes of compressor stations with bypass system in the EGIES risk evaluation. Three outage models representing the multi-states and multi-failure-modes of compressor stations and a bi-level Monte Carlo sampling algorithm for the models are developed. A novel network model of EGIES considering the compressor stations with multiple failure modes is presented. An EGIES with a modified RBTS and an 11-node gas system is used to demonstrate the effectiveness of the proposed method and models. The results indicate that compressor stations have both positive and negative significant impacts on the risk of EGIES. The bypass systems for the compressor stations can effectively offset the negative impacts. Ignoring compressor stations and their station failures in the risk evaluation of EGIES may result in an inaccurate estimation of the system risk levels and even lead to a misleading conclusion in system planning.
Thermogravimetric Investigation of Spent Shiitake Substrate to Solid Biofuel

In order to minimize environmental problems related to the generation and disposal of spent mushroom substrate (SMS) from mushroom cultivation activities, this study aimed to evaluate the thermal behaviour of the spent shiitake substrate (SSS) and its resulting biochar. Analyzing biochars produced at a temperature of 350 °C (BC350) was found to be that with the highest energy potential due to a reduced amount of resulting ash and nitrogen, and larger amounts of carbon, hydrogen, fixed carbon, as well as a higher calorific value, gravimetric yield, and gravimetric yield factor. SSS and BC350 were used in thermogravimetric and kinetic analyses. Thermogravimetric analyzes were carried out in three heating rates, 10, 15, and 20 °C/min in an oxidizing atmosphere. Conversion steps relating to water loss and degradation of hemicellulose, cellulose, and lignin have been identified. The kinetic study was carried out by non-isothermal and non-isoconversional Kissinger method. The activation energies obtained were 110 and 136 kJ⋅mol−1 for the SSS and BC350, respectively, and are well within the range found for other lignocellulosic materials, such as bagasse and wheat straw. The pre-exponential factor, in the order of 108, indicated the presence of complex elements. This article is protected by copyright. All rights reserved
PHYSIOLOGY OF THE CORPUS LUTEUM: II. Production of a Special Uterine Reaction (Progestational Proliferation) by Extracts of the Corpus Luteum

Extracts of corpus luteum were given to mated rabbits whose ovaries had been removed in order to demonstrate the effect of these extracts on the uterus. Extracts were prepared from swine corpus luteum tissue preserved in alcohol by hot alcohol extraction followed by extraction with peroxide-free ether and acetone. 18 hours after an adult female was mated with 2 males the animal was anesthetized and both ovaries and a small piece of uterus removed. The extract was administered immediately following surgery and twice daily thereafter for a total of 5 doses. The animals were killed 1 day after the final dose and genital tract and other tissues removed for examination. Results were measured by the degree of progestaional proliferation. Tests of the extracts were made with 5 preparations administered to 8 animals. Follicular fluid was collected in order to ascertain whether this was the cause of the progestational proliferation. Fresh placentas were treated similarly. Extracts of follicular fluid and placenta were without a progestational effect suggesting that a hormone in the corpus luteum was responsible for the progestational effect.
Variation of nitrogen accumulation and yield in response to phosphorus nutrition of soybean (Glycine max L. Merr.)

ABSTRACT Phosphorus (P) is essential macronutrient for soybean [Glycine max (L.) Merr. ] growth and function. The objective of this study was to determine effect of phosphorus nutrition (including phosphorus nutrition level and interruption of phosphorus supply) on nitrogen accumulation, nodule nitrogen fixation and yield of soybean plants by 15N labeling with sand culture. The results showed that they all presented a single peak curve with improvement of phosphorus nutrition level, when phosphorus concentration of nutrient solution was about 31 mg/L, they all reached the maximum and effect of phosphorus nutrition level on nodule nitrogen fixation was lower than that on yield formation level. Interruption of phosphorus supply during soybean growth period, nitrogen accumulation and nodule nitrogen fixation were seriously inhibited, and yield was decreased significantly when interruption of phosphorus supply during V3-R1 and R1-R5 period, while interruption of phosphorus supply during R5-R7 period had no significant effect on nitrogen accumulation, nodule nitrogen fixation and yield. So soybean nitrogen metabolism and yield were sensitive to phosphorus nutrition in the V3-R5 period, those were not sensitive to phosphorus nutrition after R5 period.
Using Sentiment Information for Preemptive Detection of Harmful Comments in Online Conversations

The challenge of automatic moderation of harmful comments online has been the subject of a lot of research recently, but the focus has been mostly on detecting it in individual messages after they have been posted. Some authors have tried to predict if a conversation will derail into harmfulness using the features of the first few messages. In this paper, we combine that approach with previous work on harmful message detection using sentiment information, and show how the sentiments expressed in the first messages of a conversation can help predict upcoming harmful messages. Our results show that adding sentiment features does help improve the accuracy of harmful message prediction, and allow us to make important observations on the general task of preemptive harmfulness detection.
Medium-Frequency Oscillation in Voltage-Controlled Full-Bridge Inverter with a Nonlinear Inductor

An inverter, whose inductor current is periodic, is the key equipment for photovoltaic power generation, fuel cell power generation, etc. A nonlinear inductor, whose inductance will be changed by its current, can be used to improve the grid current quality of the inverter, although making the mathematical model of the inverter system more complex. In this paper, the voltage-controlled full-bridge inverter with a nonlinear inductor is investigated and its mathematical model is established. The influence of parameters on the dynamical behaviors of this system is analyzed by using the harmonic balance method and the Floquet theory. Consequently, the mechanism for the occurrence of medium-frequency oscillation is revealed. The hardware circuit for the voltage-controlled full-bridge inverter with a nonlinear inductor is designed and some experimental results are presented for confirmation. The research results show that the mechanism for the occurrence of medium-frequency oscillation is Hopf bifurcation and its oscillation frequency is between the line frequency and the switching frequency.
State of the Field: The Need for
 Self‐Report
 Measures of Health and Quality of Life for People With Intellectual and Developmental Disabilities

Background: Collecting self-reported health and quality of life (QoL) outcomes is increasingly considered best practice, but people with intellectual and developmental disabilities (IDD) are often excluded from patient-reported outcome measures. Objective: This article provides a literature-informed overview of the state of the ﬁ eld of self-reporting of physical health and QoL in research with adults with IDD. Approach: We ﬁ rst identi ﬁ ed and synthesized de ﬁ nitions of key constructs related to the self-reporting of health. Next, we summarize literature on existing and emerging practices focused on health and QoL assessment, discussing the frequent and sometimes overly broad use of proxy-respondents in the IDD ﬁ eld. We then highlight emerging directions focused on cognitive accessibility and universal design. Finally, we provide conclusions and recommendations for the ﬁ eld. Conclusions: Informed by the literature, we provide action steps to guide the ﬁ eld in considering how to incorporate self-reporting of health outcomes by people with IDD in research, policy, and practice.
Existential Driving Forces to Work after Retirement: The Example of Physicians’ Mentoring

The article addresses physicians who work as group supervisors or mentors in a training program after having formally retired. The driving forces to continue to work are analyzed in terms of the development of existential meaning of work at a particular stage of the life cycle. We argue that a deeper understanding of the existential driving forces, that both cause physicians to accept post-retirement mentoring tasks and that is awakened and developed in this specific work, would contribute to a deeper understanding of why individuals continue working into old age. However, in political discussions of an extended working life, similar aspects tend to be disregarded. Understanding the existential driving forces that cause an individual to continue working after retirement may be crucial to comprehending how we can take advantage of the resources of the older workforce and, thus, realize human potential at a later stage of the life cycle.
A dynamic reframing of the social/personal identity dichotomy

For decades, scholars in organizational and social psychology have distinguished between two types of identity: social and personal. To what extent, though, is this dichotomy useful for understanding identities and their dynamics, and might a different approach facilitate deeper insight? Such are the guiding questions of this article. I begin by reviewing framings of the social/personal identity dichotomy in organizational psychology, and tracing its origins and evolution in social psychology. I then evaluate the strengths and limitations of this dichotomy as a tool for understanding identities. In an attempt to retain the dichotomy’s strengths and overcome its limitations, I present a modified conceptualization of the social and personal dimensions of identity, one that defines these dimensions based on psychological experience (not identity content), and treats them as two independent continua (not two levels of a dichotomy, or opposing ends of a continuum) that any given identity varies along across contexts. Plain language summary A single person can identify with lots of different aspects of their life: their family, community, job, and hobbies, to name but a few. In the same way it helps to group different items in a shop into sections, it can be helpful to group the different identities available to people into categories. And for a long time, this is what researchers have done: calling certain identities “social identities” if based on things like race and culture, and “personal identities” if based on things like traits and habits. In this paper, I explain that for various reasons, this might not be the most accurate way of mapping identities. Instead of categorizing them based on where they come from, I suggest it’s more helpful to focus on how identities actually make people feel, and how these feelings change from one moment to the next. I also point out that many identities can make someone feel like a unique person and part of a broader group at the same time. For this reason, it’s best to think of the “social” and “personal” parts of an identity not as opposites—but simply different aspects of the same thing.
Secure Repackage-Proofing Framework for Android Apps Using Collatz Conjecture

App repackaging has been raising serious concerns about the health of the Android ecosystem, and repackage-proofing is an important mitigation against threat of such attacks. However, existing app repackage-proofing schemes were only evaluated against trivial adversaries simulated using analyzers for other purposes (e.g., disclosing privacy leakage vulnerabilities), hence were shown “effective” mainly because their key programming features were not even supported by those toolkits. Furthermore, existing works have also neglected dynamic adversaries capable of manipulating victim apps at runtime, making them vulnerable against such stronger opponents. In this article, we propose a novel repackage-proofing framework, which deploys distributed detection and response sites into the subject app's native partition to cross-verify all its code files. The detection sites transmit obtained integrity metrics to response sites via secure communication channels built on the subject app's own control flows using a specialized obfuscation technique based on Collatz conjecture, turning the repackage-proofing process into complicated implicit flows that are intrinsically difficult to be resolved due to the conjecture's nonlinear dynamical behaviors. We evaluated our framework using sophisticated Android data-flow analyzers. Results showed that our prototype effectively impeded analyses aiming to trace the information flows of its cross-verification.