Miracle-dz/UniFAR-FTUs huggingface dataset:
Association of Thyroid Function with Blood Pressure and Cardiovascular Disease: A Mendelian Randomization

Thyroid function has a widespread effect on the cardiometabolic system. However, the causal association between either subclinical hyper- or hypothyroidism and the thyroid hormones with blood pressure (BP) and cardiovascular diseases (CVD) is not clear. We aim to investigate this in a two-sample Mendelian randomization (MR) study. Single nucleotide polymorphisms (SNPs) associated with thyroid-stimulating hormone (TSH), free tetraiodothyronine (FT4), hyper- and hypothyroidism, and anti-thyroid peroxidase antibodies (TPOAb), from genome-wide association studies (GWAS), were selected as MR instrumental variables. SNPs–outcome (BP, CVD) associations were evaluated in a large-scale cohort, the Malmö Diet and Cancer Study (n = 29,298). Causal estimates were computed by inverse-variance weighted (IVW), weighted median, and MR-Egger approaches. Genetically increased levels of TSH were associated with decreased systolic BP and with a lower risk of atrial fibrillation. Hyperthyroidism and TPOAb were associated with a lower risk of atrial fibrillation. Our data support a causal association between genetically decreased levels of TSH and both atrial fibrillation and systolic BP. The lack of significance after Bonferroni correction and the sensitivity analyses suggesting pleiotropy, should prompt us to be cautious in their interpretation. Nevertheless, these findings offer mechanistic insight into the etiology of CVD. Further work into the genes involved in thyroid functions and their relation to cardiovascular outcomes may highlight pathways for targeted intervention.
Hyper Elliptic Curve Based Certificateless Signcryption Scheme for Secure IIoT Communications

: Industrial internet of things (IIoT) is the usage of internet of things (IoT) devices and applications for the purpose of sensing, processing and communicating real-time events in the industrial system to reduce the unneces-sary operational cost and enhance manufacturing and other industrial-related processes to attain more profits. However, such IoT based smart industries need internet connectivity and interoperability which makes them susceptible to numerous cyber-attacks due to the scarcity of computational resources of IoT devices and communication over insecure wireless channels. Therefore, this necessitates the design of an efficient security mechanism for IIoT environment. In this paper, we propose a hyperelliptic curve cryptography (HECC) based IIoT 51.31% more efficient in computational cost and communication overhead, respectively, compared to the most recent protocol.
Visual Routines For Outdoor Navigation

This paper describes several visual routines which can be used to assist the navigation of a car in an outdoor environment. These routines are based on the grouping of edge chains in two classes of straight segments and on a suitable segmentation of the image in different regions. Such routines are able to provide a preliminary recovery of the 3D structure of the viewed scene, in which the sides of the road and the buildings are detected, and to recognize several landmarks, such as street signs, trees and light lamps. These results suggest that it is possible to construct drivers' assistant systems based on computer vision technologies.
The Risks and Rewards of Organized Crime Investments in Real Estate

Despite growing interest in organized crime’s infiltration of the legal economy, research to date has paid little attention to the investments of criminal organizations in real estate. Using data on confiscated assets in 8,092 Italian municipalities between 2000 and 2012, this paper aims to remedy this lack of knowledge. Applying a risk–reward approach, based on the rational choice perspective, the analysis highlights what drives Italian mafia groups’ investments in the real estate sector. The results obtained support the validity of the rational choice perspective by showing how criminal organizations weigh risks and rewards in their decisions to invest in real estate.
ENDOSKOPİK GÖRÜNTÜLERİN DEĞERLENDİRİLMESİNDE GÖRÜNTÜ İŞLEME TEMELLİ AKILLI BİR KARAR DESTEK SİSTEMİ

Bu calismada, kolonoskopik video goruntulerindeki poliplerin yerlerini belirleyen, hekime yardimci akilli bir karar destek sistemi sunulmustur. Sistem, dalgacik donusumu es olusum matrislerinden cikarilan oznitelikler ile yapay sinir aglari siniflandiricisindan olusmaktadir. Onerilen sistem polip ve normal dokularin bulundugu bir dizi kolonoskopik video goruntusune uygulanmistir. Elde edilen deneysel sonuclar ozgulluk ve duyarlilik analizi ile degerlendirilmistir. Kullanilan degerlendirme kriterince gerceklestirilen butun uygulamalarin sonucunda ortalama % 90.2 duyarlilik ve % 88.7 ozgulluk degerleri elde edilmistir.
A new modulation strategy for a buck-boost input AC/DC converter

This paper presents a novel modulation strategy for a power factor corrected (PFC), isolated AC/DC converter derived from the integration of a nonisolated, two switch buck-boost AC/DC converter with an isolated dual active bridge DC/DC converter (2SBBDAB). This strategy, termed discontinuous leading/trailing edge (DLTE) modulation, serves to maximize the duty cycle of the input switch while keeping the current in the buck-boost inductor discontinuous. Hence, the crest factors of the currents in the switching devices are minimized, the input switch is turned on at zero current and the zero-voltage switching ranges of the bridge switches are unaffected by the integration. A conventional isolated, PFC AC/DC converter typically consists of a boost converter cascaded with a forward converter. The ratings required of the power switching devices of the 2SBBDAB employing the DLTE modulation strategy are similar to those required of the conventional design for wide line voltage operation. However, the 2SBBDAB converter has higher line voltage surge immunity than that of the conventional design and, unlike the conventional design, it has inherent inrush current limiting. The DLTE modulation strategy may be applied to the family of converters composed of the two switch buck-boost integrated with half and full-bridge forward converters.
Invasive Meningococcal Disease Remains a Health Threat in Vietnam People’s Army

Objective Despite strict surveillance, Neisseria meningitidis still causes life-threatening invasive meningococcal disease (IMD). The study aimed to describe the prevalence, clinical and subclinical features, and treatment outcomes of IMD among young soldiers of the Vietnam People’s Army. Methods A prospective, population-based surveillance study was conducted in all Vietnamese military hospitals from January 2014 to June 2021. The presence of Neisseria meningitidis was confirmed by PCR or culture from blood or/and CSF. Epidemiological indices (incidence, serogroups, and distribution of cases by length of service), medical history, clinical and sub-clinical features, and treatment outcomes were documented and analyzed. Results There were 69 IMD cases (91% serogroup B) documented, mainly in conscripts (91%). The highest annual incidence was 3.33/100,000 soldiers per year. Of these cases, 44% were meningitis (n=30), 19% septicemia (n=13), and 38% meningococcemia (n=26). The most common clinical symptoms were neck stiffness (61 cases, 88%), petechial rash (51%), and shock (20 cases, 29%). Laboratory findings showed leukocytosis in 96% of IMD cases, PCT >0.05 (ng/mL) in 100%, elevated leukocyte count (>1,000/mm3) in 71%, and high protein >1 g/L in 70%. The overall mortality rate was 9%. Two cases were found to be resistant to ceftriaxone. Prognostic factors of severity included petechial rash (OR = 9.82, p < 0.001), septicemia (OR = 5.83, p < 0.001), meningococcemia (OR = 6.22, p < 0.001), low platelet count, prolonged prothrombin time; high PCT (AUC = 0.84, p < 0.001), and increased creatinine (AUC = 0.86, p < 0.001). Conclusion IMD remains a health threat in the armed forces in Vietnam, especially among new recruits. To the best of our knowledge, this is the first study in Vietnam describing ceftriaxone resistance in Neisseria meningitidis and suggests the need to reconsider standard empiric therapy for IMD.
Lentinus squarrosulus Mont. Mushroom: Molecular Identification, In vitro Anti-Diabetic, Anti-Obesity, and Cytotoxicity Assessment.

Objectives Mushrooms are fungi with nutritional and health benefits. Lentinus squarrosulus Mont. , an edible fungus, has traditional usage and relevance in local therapy for managing metabolic diseases. In that view, this study aimed to evaluate the in vitro anti-obesity, anti-diabetic, and cytotoxic potential of the chloroform/methanol extract (CME) and aqueous extract (AE) of the mushroom. Materials and Methods L. squarrosulus was identified using molecular biology tools. The CME and AE were obtained sequentially and, then, subjected to α-amylase, α-glucosidase, and lipase inhibitory enzyme assays as well as total phenolic content (TPC) and flavonoid content (TFC) estimations. The cytotoxic potential of extract fractions of L. squarrosulus was assessed using the brine shrimp lethality assay. Results The molecular identification of the mushroom displayed that the internal transcribed spacer sequence was an equivalent match to that of L. squarrosulus with a high percentage similarity, and thus assigned a unique accession number (KT120043.1). The CME of L. squarrosulus had higher TPC, TFC, and α-glucosidase inhibitory activity than AE. Furthermore, AE of the mushroom showed a higher lipase inhibitory potential with an IC50 value of 22.28 ± 0.65 μg/mL than the CME, while that of the reference, i.e. orlistat was 2.28 ± 0.34 μg/mL. However, these extracts exhibited very low or no α-amylase inhibitory and cytotoxic activity at the tested concentrations. Conclusion This study reveals that CME of L. squarrosulus, rich in polyphenols and flavonoids, possesses considerable α-glucosidase and lipase inhibitory activities.
Focusing phase imaging for Lamb wave phased array

In Lamb wave-based structural health monitoring, amplitude damage imaging is commonly used because the defects feature can be easily amplified by summing all the response signals together. However, the grating and side lobes affect the imaging quality and blind areas further restrict the inspection area. Considering that the existing phase-based imaging algorithms are either unfit for dispersive Lamb wave or strict to many requirements to guarantee better performance, inspired by the absence of phase information in focusing phased array, a novel focusing phase imaging (FPI) method for Lamb wave phased array is developed. The main contribution of the paper is introducing the phase information to focusing phased array. By applying the inverse-dispersion effect to the excitation signals and the superposition operation, the energy can be focused at every inspection point. The phase damage index is constructed by directly measuring the degree of consistency and alignment of the instantaneous phases. The experiments for the circular and linear array under various excitation signals with multiple defects verify that the FPI is effective for both surface damage and through-hole damage. The proposed algorithm is superior for its ability in energy focusing for defects, the capability in suppression of grating and side lobes, strong anti-disturbance ability from boundary reflection, the nonexistence of imaging blind area, and its adaptability for various excitation parameters and array layout.
Real-time tracing of spermatozoa

A system for improved evaluation of sperm progression is described. Modern andrology laboratories evaluate semen to analyze male ejaculate and to determine male infertility. Many computer assisted sperm analysis (CASA) instruments have been developed to evaluate sperm progression. To overcome the disadvantages of the existing CASA instruments, a real-time spermatozoa tracing system (RSTS) was developed. The RSTS monitors spermatozoa entering a fixed microscope field and traces their paths over a period of time, thus providing kinematic measurements. The RSTS is comprised of a general microscope with imaging equipment, and it enables the user to manipulate the specimen as desired. This article shows how the RSTS differs from conventional CASA instruments and how the proposed system provides an accurate and efficient method for evaluating sperm progression in real time.
Adaptive wavefront sensor based on the Talbot effect

The possibilities of wavefront curvature measuring by Talbot sensor are theoretically and experimentally investigated. A new method of wavefront aberrations measurement is proposed and demonstrated. It is based on the observation of the Talbot effect when the diffraction grating is adapted to the wavefront curvature of the analyzed wave. Herewith, the observation plane stay fixed and corresponds to the Talbot length for a plane wave. It is shown that the measurement range can be made several times wider, with the help of the adaptive Talbot sensor, by retaining the required angular sensitivity. A possibility of self-reproduction of the rectangular grating (with different periods along the axes) by the astigmatic wavefront is experimentally demonstrated. The possibility of the experimental realization of the adaptive Talbot sensor using the dynamic spatial light modulator is demonstrated.
Knowledge into the Practice against COVID-19: A Cross-Sectional Study from Ghana

The COVID-19 pandemic has affected populations globally, including Ghana. Knowledge of the COVID-19 disease, and the application of preventive public health interventions are pivotal to its control. Besides a lockdown, measures taken against the spread of the virus include the wearing of face masks, social distancing, regular hand washing with soap and, more recently, vaccination against the virus. In order to establish a possible link between the knowledge of the disease and compliance with preventive measures, including vaccination, a cross-sectional study employing an interview-structured questionnaire was conducted in six regions of Ghana (n = 1560). An adequate level of knowledge of COVID-19 (69.9%) was reported. The linear multiple regression analysis further explicated the differences in the knowledge of COVID-19 among the respondents by their knowledge of cholera and influenza (adjusted R-Square = 0.643). Despite this profound knowledge of the illness, two thirds of the respondents were unwilling to follow basic preventive measures and only 35.3% were willing to be vaccinated. Amazingly, neither knowledge of COVID-19 nor the socio-demographic characteristics had any meaningful influence on the practice of preventive measures. Personal attitude leading to efficient public compliance with preventive measures, therefore, is a critical issue demanding special attention and effective interventions by the government and locals with authority to curb the spread of the pandemic which surpasses the traditional channels of public health communication. This includes a roll-out of persuasion, possibly including public figures and influencers, and in any case, a balanced and open discussion addressing the acceptance of the COVID-19 vaccine in order to avoid new variants and comparable problems currently facing many countries of Western Europe. Indeed, a profound hesitancy against vaccination may turn African countries such as Ghana for many years into hotspots of new viral variants.
A guide on extracting and tidying tweets with R

Social media platforms represent a deep resource for academic research and a wide range of untapped possibilities for linguists (D'ARCY; YOUNG, 2012). This rapidly developing field presents various ethical issues and unique challenges regarding methods to retrieve and analyze data. This tutorial provides a straightforward guide to harvesting and tidying Twitter data, focused mainly on the Tweets' text, by using the R programming language (R CORE TEAM, 2020) via Twitter's APIs. The R code was developed in Adams (2020), based on the rtweet package (KEARNEY, 2018), and successfully resulted in a script for corpora compilation. In this tutorial, we discuss limitations, problems, and solutions in our framework for conducting ethical research on this social networking site. Our ethical concerns go beyond what we "agree to" in terms of use and privacy policies, that is, we argue that their content does not contemplate all the concerns researchers need to attend to. Additionally, our aim is to show that using Twitter as a data source does not require advanced computational skills.
Design and Analysis of a Rotor Blade Optimized for Extracting Energy From the Florida Current

The Florida Current flowing past Southeast Florida represents an untapped renewable energy resource with a mean kinetic energy flux near its core of 2.32 kW/m2 . The research presented in this paper details the hydrodynamic optimization of a three meter diameter, three-bladed rotor for an experimental research turbine. The proposed deployment site for this turbine is located 24 km off the coast of Southeast Florida in 300 m of water. At this location, thirteen months of continuous ocean current profile measurements have been collected. A genetic algorithm rotor optimization code was used to vary the geometry of the proposed rotor to maximize the average power output using the oceanographic measurements. The optimized rotor, operating in the observed flow field, is predicted to produce a mean shaft power of 7.153 kW when operating at 40 RPM. A sensitivity analysis shows that by increasing the RPM by 25% and 50%, the average power output can be increased by 3.56% and 4.99% respectively. Additionally, using a four-bladed rotor can increase the average power output by 4.22% when operating at 40 RPM.Copyright © 2011 by ASME
Wideband planar microstrip crossover with high power handling capability and low distortion

The design of a planar four‐port microstrip crossover is presented. The design starts by using a half‐wavelength square patch and two sets of orthogonal feeding lines. To achieve a wideband performance, four circular slots are introduced in the square patch. A parametric analysis is used to investigate the effect of the utilized slots. Full‐wave simulations and measurements are used to validate the proposed design. The simulated and measured data show less than 1 dB insertion loss, more than 10 dB return loss, more than 19 dB isolation, and about 0.2 ns group delay deviation across the band from 2.1 to 2.75 GHz. © 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 55:439–443, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.27335
Vortex Flow on the Surface Generated by the Onset of a Buoyancy-Induced Non-Boussinesq Convection in the Bulk of a Normal Liquid Helium

The onset of the Rayleigh–Benard convection (RBC) in a heated from above normal He-I layer in a cylindrical vessel in the temperature range Tλ < T ≤ Tm (RBC in non-Oberbeck–Boussinesq approximation) is attended by the emergence of a number of vortices on the free liquid surface. Here, Tλ = 2.1768 K is the temperature of the superfluid He-II–normal He-I phase transition, and the liquid density passes through a well-pronounced maximum at Tm ≈ Tλ + 6 mK. The inner vessel diameter was D = 12.4 cm, and the helium layer thickness was h ≈ 2.5 cm. The mutual interaction of the vortices between each other and their interaction with turbulent structures appeared in the layer volume during the RBC development gave rise to the formation of a vortex dipole (two large-scale vortices) on the surface. Characteristic sizes of the vortices were limited by the vessel diameter. The formation of large-scale vortices with characteristic sizes twice larger than the layer thickness can be attributed to the arising an inverse vortex cascade on the two-dimensional layer surface. Moreover, when the layer temperature exceeds Tm, convective flows in the volume decay. In the absence of the energy pumping from the bulk, the total energy of the vortex system on the surface decreases with time according to a power law.
Performance and Sensitivity Properties of Solid Heterogeneous Rocket Propellant Based on a Binary System of Oxidizers (PSAN and AP)

Solid heterogeneous rocket propellants (SHRP) containing ammonium perchlorate (AP) emit a lot of hydrogen chloride (HCl) during combustion, which poses various environmental issues and makes the detection of the rockets easier. Part of the AP can be replaced by ammonium nitrate (V) (AN), which does not lead to the production of HCl. AN is a commonly used environmentally friendly oxidizer, but it is not usually applied in SHRP due to its disadvantages. One of these disadvantages is a phase transition near room temperature, which causes the density change of AN. Three types of phase stabilized ammonium nitrate (V) (PSAN) with inorganic potassium salts were obtained in order to shift this transition into higher temperatures (above the temperature range of the storage and the usage of SHRP). The SHRP with the PSAN were obtained, and the measurements of the heat of combustion, density, hardness, the sensitivity to mechanical stimuli and the thermomechanical properties were performed. The obtained propellants were characterized by similar operational parameters or were slightly lower than those without the PSAN. This means that AP can be partially replaced without significantly compromising the handling, safety or functionality of the propellants, while increasing the environmental performance of the solution.
Dynamics of Quadriceps Muscles during Isometric Contractions: Velocity-Encoded Phase Contrast MRI Study

Objective: To quantify the spatial heterogeneity of displacement during voluntary isometric contraction within and between the different compartments of the quadriceps. Methods: The thigh muscles of seven subjects were imaged on an MRI scanner while performing isometric knee extensions at 40% maximal voluntary contraction. A gated velocity-encoded phase contrast MRI sequence in axial orientations yielded tissue velocity-encoded dynamic images of the four different compartments of the thigh muscles (vastus lateralis (VL), vastus medialis (VM), vastus intermedius (VI), and rectus femoris (RF)) at three longitudinal locations of the proximal–distal length: 17.5% (proximal), 50% (middle), and 77.5% (distal). The displacement, which is the time integration of the measured velocity, was calculated along the three orthogonal axes using a tracking algorithm. Results: The displacement of the muscle tissues was clearly nonuniform within each axial section as well as between the three axial locations. The ensemble average of the magnitude of the total displacement as a synthetic vector of the X, Y, and Z displacements was significantly larger in the VM at the middle location (p < 0.01), and in the VI at the distal location than in the other three muscles. The ensemble average of Z-axis displacement, which was almost aligned with the line of action, was significantly larger in VI than in the other three muscles in all three locations. Displacements of more than 20 mm were observed around the central aponeuroses, such as those between VI and the other surrounding muscles. Conclusions: These results imply that the quadriceps muscles act as one functional unit in normal force generation through the central aponeuroses despite complex behavior in each of the muscles, each of which possesses different physiological characteristics and architectures.