Miracle-dz/UniFAR-FTUs huggingface dataset:
INDIAN MUSIC THERAPY: COULD IT BE HELPFUL IN THE MANAGEMENT OF MENTAL DEPRESSION?

The literature shows evidence that music is an effective means of aiding in treatment of mental depression. However, Indian classical music which has been widely used as an adjuvant therapy in mental depression lacks the scientific research to establish a proper area of medical treatment. Hence an attempt was made to study the effect of few selected ragas of Indian Classical Music on mental depression. The study was conducted on 40 clinically diagnosed mentally depressed patients, in the age group of 15- 45 years who were not undergoing any medical treatment. These patients were given music therapy for 45-60 minutes each day for a period of 15 days. Patients were analyzed based on the Goldberg questionnaire before and after the therapy. Clinically diagnosed severe depressive patients were excluded from the study. We found a profound decrease in the levels of depression in an individual, post-therapy, based on the Goldberg Depression Questionnaire scoring. The results showed, the significant difference in the pre-therapy to post-therapy score favoring a decrease in the level of depression (P < 0.0001). According to the Goldberg Depression Questionnaire, a 5 point change in the score is significant. Further studies based on biochemical parameters could show more accurate results in the future and effect of music therapy on other vital parameters of the body and experimenting with the variation in the effect in correlation with the type of music used could show great promise.
Carotid-femoral pulse wave velocity in patients with isolated coronary artery ectasia: an observational study.

OBJECTIVE Carotid-femoral pulse wave velocity (PWV), the current "gold-standard" measure of arterial stiffness, has emerged as an important independent predictor of cardiovascular events. The increased PWV is recognized as an indicator of atherosclerosis. The relationship between isolated coronary artery ectasia (CAE) and carotid-femoral PWV has not been well-described. The aim of our study was to assess this relation. METHODS Thirty-four patients with isolated CAE without any visible coronary stenosis and 24 control subjects with angiographically normal coronary arteries were enrolled to this cross-sectional observational study. Applanation tonometry was applied to assess the carotid-femoral PWV. Statistical analyses were performed by Mann-Whitney U and Chi-square tests. Multiple linear regression analysis was used for the evaluation of the relations of parameters. RESULTS The baseline clinical and laboratory parameters of the both groups were similar. Patients with isolated CAE had significantly higher carotid-femoral PWV compared to control subjects (10.5±2.4 vs 9.2±1.7 m/s, p=0.02). In multiple regression analysis, age (beta=0.23, 95% CI=0.001-0.094, p=0.04), number of ectatic vessels (beta=0.24, 95% CI=0.044-1.07, p=0.03), and systolic blood pressure (beta=0.52, 95% CI=0.028-0.1, p=0.001) were found independently related to PWV. CONCLUSION We have shown an association between increased carotid-femoral PWV and isolated CAE, suggesting that atherosclerosis may be involved in the pathogenesis of isolated CAE without any coronary stenosis in the adult population.
Creation and Implementation of a Computer Validation Program*

Computer validation programs should be developed and implemented to ensure that systems and programs perform their intended functions. The process of computer validation is broken down into ten components: administration, requirements, design, testing, operation, security, maintenance, change control, record retention and periodic review. Company guidelines and government regulations also must be considered. Implementation of a validation program involves creating awareness, providing training and education on an ongoing basis, and developing a method of auditing to determine level of compliance and enable appropriate adjustment. In addition, it is recognized that responsibility for a system ultimately rests with the end-users.
Validity of the Turkish version of the European Heart Failure Self-Care Behavior Scale.

OBJECTIVE The specific purpose of this study was to investigate the validity of the Turkish version of the European Heart Failure Self-care Behavior Scale by applying to 494 Turkish Heart Failure Patients. METHODS The study was conducted as a cross-sectional sample survey, between October 2012 and January 2013. The 494 patients who applied with a diagnosis of heart failure were included in the study after determining the clinical diagnosis and type of treatment. Cronbach's alpha coefficient was used to evaluate the validity and reliability of the scale. Exploratory and confirmatory factor analyses were applied for the determination of the sub-factors of the scale in Turkish adaptation; content, item and factor adaption. Structural Equation Modeling was used for the purpose of creation and supervision of the structural models of the scale. RESULTS Cronbach's alpha coefficient of internal consistency of Turkish version of the Scale was found to be 0.69. According to the results of the factor analysis, it was determined that the data is in a form suitable for factor analysis and the data have the assumption of multivariate normal distribution. The goodness of fit measures used for the validity of Structural Equation Modeling were obtained to be RMSEA=0.047 (CI=0.00-0.079), AGFI=0.83, GFI=0.91 respectively. CONCLUSION The scale is divided into 4 sub-factors according to the Structural Equation Modeling. The European Heart Failure Self-care Behavior Scale is a scale that easily applied to measure the behavior of self-care in heart failure patients. In addition, the scale reaches the conclusion as soon as possible and does not require additional training for researchers. Further, patients can apply themselves the scale easily.
Cardiohepatic interactions in heart failure.

1. Roper VL, Go AS, Lloyd Jones DM, Benjamin EJ, Berry JD, Borden WB, et al. On hehalf of the American Association Statistics Committee and Stroke Statistics Subcommittee Heart Disease and Stroke Statistics-2012 Update: a report from the American Heart Association. Circulation 2012; 125: e2-e220. 2. Arikan I, Metinta§ S, Kalyoncu C, Yildiz Z. The cardiovascular disease risk factors knowledge level (CARRF-KL) Scale: a validity and reliahility study. Turk Kardiyol Dern Ars 2009; 37: 35-40. 3. Oyuz S, Cesur K, Koç S. Coronary heart diseases risk factors in the determination of nursing students. Turk Soc Cardiol Turkish J Cardiol Nursing 2011:1:18-21. 4. Webb E, Ashton H, Kelly R Kamali E Patterns of alcohol consumption, smoking and illicit drug use in British university students: in faculty comparisons. Drug Alcohol Depend 1997; 47:145-53. 5. Global Recommendations on Physical Activity for Health. The World Health Organization; 2010.p.9-11. 6. Metlnta? S, Bugrul N, Öztürk A, Kalyoncu C. Cardiovascular risk factors knowledge levels among high school students at Sivrihisar. 15. Nationai Public Health Congress; 2-6.10. 2012; Bursa; Accessed on: 31.10. 2012. Available from: URL: htt///halksagligiokulu.org/anasayfa/components/com_ booklibrary/ebooks/15.UHSK%20K%C4%B0TAP_14J0_12. pdf
Advances in the treatment of follicular lymphoma

Introduction: Follicular lymphoma, the most common of the indolent non-Hodgkin lymphomas, exhibits a highly variable clinical course. The disease is characterized by a high response rate to therapy, but due to repeated relapses additional treatment options are necessary. Areas covered: The rediscovered chemotherapeutic agent, bendamustine, has demonstrated remarkable efficacy and tolerability when paired with rituximab and has been established as a front-line regimen. More recently, a number of new targeted therapies have been developed, directed against intrinsic drivers of malignant B-cell proliferation and survival, and extrinsic factors such as the tumor microenvironment and escape from the immune response. For the first time, a targeted oral agent, idelalisib, is now FDA approved for the treatment of this disease. Expert opinion: The promise of these new therapies has enabled us to move forward with multi-targeted biologic regimens and toward a future of individualized treatment without traditional chemotherapy.
Biochemical characterization of recombinant β-carbonic anhydrase (PgiCAb) identified in the genome of the oral pathogenic bacterium Porphyromonas gingivalis

Abstract Carbonic anhydrases (CAs, EC 4.2.1.1) belonging to the α-, β-, γ-, δ- and ζ-CAs are ubiquitous metalloenzymes present in prokaryotes and eukaryotes. CAs started to be investigated in detail only recently in pathogenic bacteria, in the search for antibiotics with a novel mechanism of action, since it has been demonstrated that in many such organisms they are essential for the life cycle of the organism. CA inhibition leads to growth impairment or growth defects in several pathogenic bacteria. The microbiota of the human oral mucosa consists of a myriad of bacterial species, Porphyromonas gingivalis being one of them and the major pathogen responsible for the development of chronic periodontitis. The genome of P. gingivalis encodes for a β- and a γ-CAs. Recently, our group purified the recombinant γ-CA (named PgiCA) which was shown to possess a significant catalytic activity for the reaction that converts CO2 to bicarbonate and protons, with a kcat of 4.1 × 105 s−1 and a kcat/Km of 5.4 × 107 M−1 × s−1. We have also investigated its inhibition profile with a range of inorganic anions such as thiocyanate, cyanide, azide, hydrogen sulfide, sulfamate and trithiocarbonate. Here, we describe the cloning, purification and kinetic parameters of the other class of CA identified in the genome of P. gingivalis, the β-CA, named PgiCAb. This enzyme has a good catalytic activity, with a kcat of 2.8 × 105 s−1 and a kcat/Km of 1.5 × 107 M−1 × s−1. PgiCAb was also inhibited by the clinically used sulfonamide acetazolamide, with an inhibition constant of 214 nM. The role of CAs as possible virulence factors of P. gingivalis is poorly understood at the moment but their good catalytic activity and the fact that they might be inhibited by a large number of compounds, which may pave the way for finding inhibitors with antibacterial activity that may elucidate these phenomena and lead to novel antibiotics.
Detection of fetal RhD gene from maternal blood.

OBJECTIVE Hemolytic disease of the newborn (HDN) is a clinic phenomenon which occurs during pregnancy due to the Rhesus (Rh) D alloimmunization between a Rh (-) pregnant woman, who has become sensitive to RhD antigens, and her Rh (+) fetus. As a result of the attack of maternal RhD antibodies on fetal RhD antigens, fetal anemia, HDN and fetal death may occur. % 40 of Rh (-) pregnant women carry Rh (-) fetus. However, all Rh (-) pregnant women are offered anti-D Immunoglobulin (Anti-D Ig) at 28 weeks' gestation in case of fetomaternal haemorrhage, so the pregnant women carrying Rh (-) fetus are exposed to blood products unnecessarily. Although the RhD of fetus can be detected, methods used for prenatal diagnosis recently are invasive tests and they can result in abortion in a certain percentage. The discovery of circulating cell-free fetal nucleic acids in maternal plasma has opened up new possibilities for non invasive prenatal diagnosis. The aim of this study was to detect prenatal RhD by analysing the presence of the RhD gene of fetal DNA in maternal blood. MATERIAL AND METHODS Total free DNA was isolated from the blood of 19 Rh (-) pregnant women, who had RhD alloimmunization with their husbands, in the 11-14 th week of their pregnancy. The existence of a gene in isolated DNA was investigated with TaqMan prob and "Real-time PCR" method by using primers belonging to exon 7 of RhD gene. RESULTS Using a quantitative real-time PCR assay, the presence of RhD gene sequences was evaluated in the serum of patients at the onset of pregnancy. We have analyzed 19 Rh (-) pregnant women. Twelve of them were Rh (-) and the rest of them were 7 Rh (+). After birth the baby's blood groups were concordant with our results. CONCLUSION The results obtained by RhD primer were analysed. The possibility of detection of fetal RhD gene in maternal blood contributed to noninvasive prenatal diagnosis.
Antiplatelet pyrazolopyridines derivatives: pharmacological, biochemical and toxicological characterization

Abstract Platelet aggregation is one of the main events involved in vascular thrombus formation. Recently, N′-substituted-phenylmethylene-3-methyl-1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine-4-carbohydrazides were described as antiplatelet derivatives. In this work, we explore the properties of these antiplatelet agents through a series of pharmacological, biochemical and toxicological studies. The antiplatelet activity of each derivative was confirmed as 3a, 3b and 3 h significantly inhibited human platelet aggregation induced by arachidonic acid, with no detectable effect on clotting factors or healthy erythrocytes. Importantly, mice treated with derivative 3a showed a higher survival rate at an in vivo model of pulmonary thromboembolism with a lower bleeding risk in comparison to aspirin. The in silico studies pointed a series of structural parameters related to thromboxane synthase (TXS) inhibition by 3a, which was confirmed by tracking plasma levels of PGE2 and TXB2 through an in vitro enzyme immunoassay. Derivative 3a showed selective TXS inhibition allied with low bleeding risk and increased animal survival, revealing the derivative as a promising candidate for treatment of cardiovascular diseases.
IgA lambda oligoclonal gammopathy in multiple myeloma.

brahim Tek1, Dilsa M zrak2, Gungor Utkan1, Selami Kocak Toprak3, Huseyin Tutkak4, Abdullah Buyukcelik1, Bulent Yalc n1, Hakan Akbulut1, Fikri cli1 1Department of Medical Oncology, Ankara University School of Medicine, Ankara, Turkey 2Department of Internal Medicine, Ankara University School of Medicine, Ankara, Turkey 3Department of Hematology, Ankara University School of Medicine, Ankara, Turkey 4Department of Clinical Immunology and Rheumatology, Ankara University School of Medicine, Ankara, Turkey
New treatment of cellulite with infrared-LED illumination applied during high-intensity treadmill training

Abstract Phototherapy improves cellular activation which is an important factor for the treatment of cellulite. The objective of this research was to develop and evaluate the effects of a new (noninvasive and nonpharmacological) clinical procedure to improve body aesthetics: infrared-LED (850 nm) plus treadmill training. Twenty women (25–55 years old) participated in this study. They were separated in two groups: the control group, which carried out only the treadmill training (n = 10), and the LED group, with phototherapy during the treadmill training (n = 10). The training was performed for 45 minutes twice a week over 3 months at intensities between 85% and 90% maximal heart rate (HRmax). The irradiation parameters were 39 mW/cm2 and a fluence of 106 J/cm2. The treatment was evaluated by interpreting body composition parameters, photographs and thermography. This was primarily a treatment for cellulite with a reduction of saddlebag and thigh circumference. At the same time, the treadmill training prevented an increase of body fat, as well as the loss of lean mass. Moreover, thermal images of the temperature modification of the thighs are presented. These positive effects can result in a further improvement of body aesthetics using infrared-LED together with treadmill training.
Multidisciplinary teams caring for clients with chronic conditions: Experiences of community nurses and allied health professionals

Abstract In Western societies the community prevalence of chronic conditions is increasing rapidly. Evidence has shown the benefits of care given to these clients by multidisciplinary teams. However, the experience of diverse health professionals working in these teams is not well understood. This study presents the experiences of members in multidisciplinary teams caring for clients with chronic conditions in the community. A qualitative descriptive study was used with a purposive sample of 34 multidisciplinary team members who participated in focus groups that were audio-taped, transcribed and analysed. Team members’ experiences of working in multidisciplinary teams are described within three categories: shared purpose, working in the team, and tensions within the team. The findings provide direction for addressing team effectiveness, including issues of team leadership and evaluation of team performance.
Prevalence and correlates of cigarette smoking among men who have sex with men (MSM) in Vancouver, Canada: A cross-sectional survey

Objectives: Past studies of men who have sex with men (MSM) in Canada and elsewhere have reported high prevalence of cigarette smoking. In the context of a declining prevalence of smoking in the general population, we sought to gather more recent estimates of the prevalence of smoking among a sample of MSM in Vancouver and examine correlates of current smoking status. Methods: We conducted a cross-sectional survey of MSM selected through a venue-based time-place sampling method in Vancouver. Correlates of smoking were investigated using bivariate analyses and multivariate logistic regression modeling. We also examined the association between smoking status and use of mood-altering substances. Results: A total of 37.0% (413/1115) of study participants were current smokers. HIV-positive individuals (50.0%), men under 30 years old (40.4%), and individuals earning < $20,000 per year (51.6%) reported the highest prevalence of smoking. Asian men had a much lower prevalence of smoking (20.5%) (p < 0.001 for all). Multivariate modeling found a reduced odds of smoking among individuals of Asian heritage and increased odds of smoking among individuals aged
Culturally and linguistically diverse older adults relocating to residential aged care

Abstract Objective: To explore nursing home relocation experiences of overseas-born, culturally and linguistically diverse elderly. Methods: Using a grounded theory approach, interviews were conducted with 20 residents of four nursing homes in the northern suburbs of Melbourne, Australia. Results: Consistent with the grounded theory method, the initial objectives of exploring the participants’ nursing home relocation experience focused on the pathways they had taken en route to nursing homes and the strategies used to bring their cultures with them. Conclusion: Participants made little suggestion that culture was an important consideration in their decision making about responding to loss or moving to the nursing home until they began discussing offers of care from their family. Cultural considerations are important factors in assessing the quality of a nursing home and in strategies used for settling into the home. Notably, many of the cultural practices and meanings described by residents were common to many cultures and were experienced by older adults as culturally meaningful.
Effects of physical activity on some of hemostatic parameters changes in epiphysectomized rats

This study was designed to determine the effects of physical activity on thrombin time and coagulation time in epiphysectomized rats. Male Wistar rats (n = 60) weighing 90 to 100 g were divided into 2 groups; control group (without epiphysectomy) and experimental group (epiphysectomy). In each group, animals were divided into three subgroups: control (without physical activity), short-time (5 min physical activity) and long-time (with 20 min physical activity). Blood samples were collected from rat tail tip in several stages as before and after epiphysectomy and physical activity from experimental group, to determine coagulation time. Exercise programs were performed including; swimming on water pool until 5 min (short-time) and 20 min (long-time) in experimental and control groups. Autopsy was done on all the rats. Thrombin time was measured for each tissue. Our data showed that physical activity significantly decreased thrombin time on tissues of rats as compared to baseline values in control group (P < 0.001). In contrast, physical activity significantly increased thrombin time on different tissues in epiphysectomy rats (P < 0.001). Also, our results showed that in epiphysectomized rats after long-time physical activity, coagulation time increased but after short-time it decreased. In conclusion, these results suggest that there is a functional relationship between the pineal gland and the exercise on changes of hemostatic parameters in blood via its hormone melatonin. Key words: Thrombin time, coagulation time, physical activity, epiphysectomized rats.
Association between intrapartum fetal heart rate patterns and neonatal abstinence syndrome in methadone exposed neonates

Objective. Determine whether infants exposed to chronic maternal methadone with abnormal intrapartum fetal heart rate (FHR) patterns are more likely to require treatment for neonatal abstinence syndrome (NAS). Study design. Intrapartum FHR tracings analyzed in 104 pregnancies at ≥34 weeks gestation for FHR variability, accelerations, and decelerations. FHR patterns compared between neonates based on treatment with methadone for NAS. Secondary analysis included relation between maternal methadone dose and intrapartum FHR patterns, initiation of methadone, age at methadone initiation, and total neonatal methadone dose. Study powered to detect 30% increase in NAS incidence in neonates with abnormal FHR tracings. Results. Seventy-six (73%) of 104 neonates required methadone treatment for NAS. Neonates who required methadone had higher average baseline FHR (131 vs. 126 bpm; p < 0.04) in active labor and less likely to have FHR tracings without accelerations (1.7% vs. 20.3%; p = 0.007) in latent labor. No significant associations between neonate's need for methadone and intrapartum FHR variability or FHR decelerations. No association between maternal methadone dose (range 30–280 mg) and treatment for NAS. Conclusion. The need for an infant to require methadone treatment for NAS was not reliably predicted by the intrapartum FHR patterns or the maternal methadone dose.
Dexamethasone Intravitreal Implant at the Time of Cataract Surgery in Eyes with Diabetic Macular Edema

Purpose To determine the potential role of intraoperative dexamethasone intravitreal implant (DEX-I) in reducing diabetic macular edema (DME) worsening after phacoemulsification. Methods This was a prospective study on 19 eyes of 19 patients with type 2 diabetes mellitus with DME and cataract. Mean preoperative Early Treatment Diabetic Retinopathy Study visual acuity (VA) was 16.7 letters. Mean foveal thickness (FT) was 451 μm. The DME was naive in 11 eyes and refractory in 8 eyes. All eyes underwent a standard phacoemulsification and intraocular lens implantation; DEX-I was injected at the end of surgery. Follow-up was performed at 1 week and then monthly until DME recurrence (up to 8 months). Results At 1 week, mean VA improved by 15 letters (range 0-29 letters) and mean FT decreased by 147 μm (range 69-236 μm). Improvement consolidated at month 1, with a mean VA improvement of 18 letters (range 3-32 letters) and a mean improvement in FT of 193 μm (range 76-304 μm), remaining stable at month 2 after surgery in all eyes. The DME recurred in 1 eye at month 3, in 14 eyes (73.8%) between months 4 and 5, and after month 6 in 4 eyes (21%). Refractory DMEs demonstrated the same benefit but recurred earlier than naive ones (4 months versus 5.8 months, p<0.01). Conclusions Intraoperative DEX-I prevents DME worsening after phacoemulsification. Its positive effects last for at least 3 months.