Miracle-dz/UniFAR-FTUs huggingface dataset:
Hormone-responsive organoids from domestic mare and Przewalski's horse endometrium.

The endometrium, the inner uterine lining, is composed of cell layers that come in direct contact with an embryo during early pregnancy and later with the fetal placenta. The endometrium is responsible for signals associated with normal reproductive cyclicity as well as maintenance of pregnancy. In the mare, functionally competent in vitro models of the endometrium have not been successful. Furthermore, the ability to study various reproductive processes in vitro may allow critical evaluation of signaling pathways involved in the reproductive diseases of animals that cannot be handled frequently, such as various wildlife species. Here we report the establishment of organoids, three-dimensional structures, derived from fresh and frozen-thawed equine endometrium (Equus ferus caballus and E. f. przewalskii). Although organoids from domestic mares responded to exogenous hormonal stimuli, organoids from Przewalski's horse failed to respond to exogenous hormones. The present study represents a 'first' for any large animal model or endangered species. These physiologically functional organoids may facilitate improved understanding of normal reproductive mechanisms, uterine pathologies, and signaling mechanisms between the conceptus and endometrium and may lead to development of novel bioassays for drug discovery.
On the dynamic response of a pitch/torque controlled wind turbine in a pulsating dynamic wake

The interaction between wakes and rotors is typically detrimental in terms of the overall power production of a wind farm. The recently studied wind farm controllers represent a promising way to increase the energy harvested through the mitigation of the effects induced by wake impingement. Recently, a novel methodology, based on a dynamic variation of induction, has been proposed as an alternative to steady induction and wake redirection controls. According to this new technology, a periodic collective motion of blade pitch generates a dynamic induction, associated with a stronger flow mixing and therefore a faster wake recovery. Although this technique proved to be effective in terms of power increase, both in numerical simulations and in wind tunnel experiments, much is to be done in order to demonstrate its feasibility. In particular, the impact of dynamic induction control in terms of downstream turbine dynamics has not been yet analyzed in detail. This paper presents a CFD-based analysis aimed at describing the response of a downstream rotor inside the wake of an upstream machine performing dynamic induction control. Specifically, the periodic induction entails a pulsating flow downstream which interacts significantly with the aero-servo-elastic dynamics of the downstream turbines. For low wind speeds, such an oscillating flow may trigger a shut-down/start-up sequence any time the velocity results lower than the cut-in speed.
Strategic management of healthcare institution development of the national medical services market

The article reviews the current state of the market of medical services in Europe and comparatively results with the health care system in Ukraine. The main problems of reforming the health care system of Ukraine, which is characterized by the reduction of public health institutions, insufficient funding and an increase in the number of private clinics aimed at maximizing profits, are analyzed. On the one hand, this improves the quality of medical services, as private clinics, not having public funding, but financed by consumers purchase expensive equipment and make decisions in market conditions, which contributes to the introduction of new methods and innovative technologies, while on the other hand private medicine is inaccessible to the vast majority of the population of Ukraine due to the low economic status of citizens. The article considers the problem of remoteness of settlements from health care institutions and gives recommendations for further development and management of the health care system on the national market of medical services to reduce the risk of premature loss of population and improve the health of patients. The main reasons for the decline of the population of Ukraine are described and recommendations for the transition from public to public private medicine are provided. It was found that it is necessary to increase funding for public healthcare institutions and increase their total number to preserve the human potential of Ukraine. It was concluded that the strategic management of the development of the health care system should constantly monitor the effectiveness of implementation of changes, develop a flexible system of reform and control, which would take into account regional characteristics and mentality of the Ukrainian population. In order to increase the results of public medicine functioning and improve its availability and competitiveness, it is necessary to reorganize the system of control over the targeted use of monetary resources and develop a step-by-step strategy of Ukraine's development in all areas of the medical services market.
Extension of technology continuance theory (TCT) with task technology fit (TTF) in the context of Internet banking user continuance intention

PurposeThe advancement in Internet technology has played a significant role in revolutionizing the Internet banking services. Therefore, little is discussed about factors that motivate technology user to continue the use of Internet banking services. The current study investigates Internet banking user continuance behavior toward the use of Internet banking services with the integration of two-well known information system (IS) theories namely task technology fit (TTF) and technology continuance theory (TCT). Design/methodology/approachThe research design of this study is based on positivist paradigm and followed quantitative research approach. Data were collected from 360 Internet banking users of commercial banks across Pakistan. The research model was tested with structural equation modeling (SEM). FindingsThe research model had explained 53.9% variance in Internet banking user continuance intention. Next to this, the predictive relevance of the research model was tested with Stone-Geisser's Q² values using blindfolding procedure. Results revealed that the newly developed integrated technology continuance research model has substantial power to predict Internet banking user continuance intention. Moreover, the effect size analysis revealed that factors like satisfaction and user expectation were the most important factors in determining Internet banking user continuance intention.Practical implicationsFor practical implications importance performance matrix analysis (IPMA) has used to see the importance and performance of the underpinned factors. Findings indicate that managers and policy makers should focus on user satisfaction, perceived usefulness and expectation confirmation in order to enhance the Internet banking user continuance intention toward the use of Internet banking services. Some of the ways banks can do this is to develop esthetic Internet banking website with charm of novelty, relevant information and smooth flows with less complex redirects.Originality/valueUnlike prior studies that focus on Internet banking user pre-adoption issues, the current study examines post-adoption issue of Internet banking users and investigates Internet banking user continuance intention. This study is significant as it integrates two-well known theories namely TCT and TTF in Internet banking user continuance intention and augments the IS literature by developing an integrated technology continuance model (TCM).
Anticipated stigma, stereotypes, and COVID-19 testing.

Testing for COVID-19 is important for identifying, tracing, and treating COVID-19 cases as well as informing policy decisions Evidence from other disease epidemics suggests that anticipated stigma and stereotypes are barriers to testing for disease Anticipated stigma may undermine testing due to labeling avoidance (i e , efforts to avoid receiving the label of a stigmatized status) and stereotypes may undermine testing by reducing perceived vulnerability to disease Given the importance of scaling up COVID-19 testing, the current study explored the potential roles of anticipated stigma and stereotypes in COVID-19 testing A cross-sectional, online survey was conducted with 845 United States adults in April 2020 Measures were adapted from previous studies of stigma associated with infectious diseases, and participants were asked about the likelihood that they would seek a COVID-19 test if one were to be ordered by their doctor Analyses demonstrated that participants who anticipated greater COVID-19 stigma and endorsed COVID-19 stereotypes to a greater degree reported that they would be less likely to seek a COVID-19 test Notably, endorsement of anticipated stigma and stereotypes was low, and knowledge and fear were stronger predictors of testing than stigma Nonetheless, results provide preliminary evidence that anticipated stigma and stereotypes may represent barriers to testing in the context of COVID-19, similar to other diseases As COVID-19 tests become more widely available, efforts may be needed to address COVID-19 stigma alongside other barriers such as access and knowledge to maximize testing efforts (PsycInfo Database Record (c) 2020 APA, all rights reserved)
The kinetics of copper corrosion in nitric acid

The strategy for the permanent disposal of high‐level nuclear waste in Canada involves sealing it in a copper‐coated steel container and burying it in a deep geologic repository. During the early emplacement period, the container could be exposed to warm humid air, which could result in the condensation of nitric acid, produced by the radiolysis of the humid air, on the copper surface. Previous studies have suggested that both nitrate and oxygen reduction will drive copper corrosion, with the nitrate reduction kinetics being dependent on the concentration of soluble copper(I) produced by the anodic dissolution of copper in the reaction with oxygen. This study focused on determining the kinetics of nitrate and oxygen reduction and elucidating the synergistic relationship between the two processes. This was investigated using corrosion potential and polarization measurements in conjunction with scanning electron microscopy and X‐ray photoelectron spectroscopy. Oxygen reduction was shown to be the dominant cathodic reaction with the oxidation of copper(I) to copper(II) by nitrate, promoting the catalytic cycle involving the reaction of copper(II) with copper to reproduce copper(I).
Performance of graphene dispersion by using mixed surfactants

In this work the ability of pure surfactant Sodium Dodecyl Sulfate (SDS), Cetyltrimethyl Ammonium Bromide (CTAB) and their mixed surfactants for graphene dispersion in aqueous solution was investigated. The uniform and stable dispersion solution was obtained for graphene with the mixtures of SDS and CTAB at lower concentration as compared to the pure one. The SDS-based surfactants exhibited better dispersion as compared to CTAB-based surfactants due to smaller-sized graphene as was investigated via Zeta potential measurements. Zeta potential was utilized to characterize the colloidal stability of surface charges within the mixtures. The mixed surfactants utilized in the present study showed a better ability to disperse graphene and its derivatives and hence are well suited for practical applications.
Study on factors that affect the sharing justice and network relationship to develop the engagement in freelance

The objective of this paper was to investigate the factors that affect the sharing of justice and network relation to developing the engagement in freelance. The study was conducted from in-depth interviews and used Grab as a case study of sharing economy businesses. In-depth interviews were done with experts in sharing businesses and operators who own vehicle assets. In addition, relevant literature and theories were reviewed to consider the conceptual framework and factors obtained from this study. This study is only part of the main research that the author is currently studying. From the results of the interviews, Grab’s sharing justice had a clear sharing of financial interests along with support in finding customers. In terms of network support, there was support to work together, and Grab’s members shared their career knowledge. It was found that sharing justice and network relation could well develop the engagement in freelance and that they were highly linked to each other. According to the conceptual framework and results obtained from this study, the factors that affect the development of sharing economy businesses to create the engagement in freelance could be divided into two parts: sharing justice consisting of (1) distributive justice, (2) procedural justice, and (3) interactional justice, and network relation consisting of (1) physical support, (2) knowledge sharing support, (3) emotional support, and (4) companionship support. Finally, in the near future, after data collection and analysis have been completed, the author will present this research in a complete form that presents the whole conceptual framework because some of the content is still in the process of collecting population samples.
Co-production and multimodality: learners as co-researchers exploring practice

ABSTRACT In recent decades, three forms of practitioner research have emerged: Reflective Practice, Action Research, and Exploratory Practice. While Reflective Practice and Action Research focus on teachers-as-researchers, Exploratory Practice positions learners as co-researchers, alongside teachers, teacher educators, and others. This article adds to those which examine the notion of learners co-producing research by exploring the potential of multimodal methods for data generation and analysis; it does this by critically analysing posters produced by learners as they puzzled, explored, collaborated, and disseminated their developing understandings on a pre-sessional English for Academic Purposes course in the UK. Focusing particularly on these ‘sticky objects’, to which emotions and beliefs attach, I argue that learners, like teachers, can ask robust questions, engage in creative investigative practices, integrating research and pedagogy. I posit that learners can develop profound insights into their practice which contribute to theory-building more broadly. This ‘fully inclusive’ notion of co-produced research challenges traditional assumptions about who does what in research and pedagogy, indicating an ethical imperative for learners to be included as co-investigators contributing their understandings to developments in theory and practice.
Systematic reliability analysis of the Dynamic Positioning (DP) control system for a deepwater drilling rig

ABSTRACT The system-level reliability analysis of DPS-3 Dynamic Positioning (DP) control system is proposed, which include both a qualitative failure modes and effects analysis (FMEA) and a quantitative analysis. The FMEA results show that the single point failure of main components of DP control system will not have any global effect on automatic positioning, however, the components involved with high Risk Priority Number (RPNs) are advised to include in the quantitative analysis. Markov model method is used to quantitatively analyze the reliability of DPS-3 control system. To simplify the process of state transition, paralleled Markov models are built to model the main and back-up control systems respectively, the reliability of the whole DP control system would be obtained with the failure rates of main and back-up subsystems. The results show that the proposed method can treat the complex architecture of the control system in an efficient manner.
Sex differences in the vascular access of hemodialysis patients: a cohort study

Abstract Background We describe differences for probability of receiving a fistula attempt, achieving fistula use, remaining catheter-free and the rate of access-related procedures as a function of sex. Methods Prospectively collected vascular access data on incident dialysis patients from five Canadian programs using the Dialysis Measurement Analysis and Reporting System to determine differences in fistula-related outcomes between women and men. The probability of receiving a fistula attempt and the probability of fistula use were determined using binary logistic regression. Catheter and fistula procedure rates were described using Poisson regression. We studied time to fistula attempt and time to fistula use, accounting for competing risks. Results We included 1446 (61%) men and 929 (39%) women. Men had a lower body mass index (P < 0.001) and were more likely to have coronary artery disease (P < 0.001) and peripheral vascular disease (p < 0.001). A total of 688 (48%) men and 403 (43%) women received a fistula attempt. Women were less likely to receive a fistula attempt by 6 months {odds ratio [OR] 0.64 [95% confidence interval (CI) 0.52–0.79]} and to achieve catheter-free use of their fistula by 1 year [OR 0.38 (95% CI 0.27–0.53)]. At an average of 2.30 access procedures per person-year, there is no difference between women and men [incidence rate ratio (IRR) 0.97 (95% CI 0.87–1.07)]. Restricting to those with a fistula attempt, women received more procedures [IRR 1.16 (95% CI 1.04–1.30)] attributed to increased catheter procedures [IRR 1.50 (95% CI 1.27–1.78)]. There was no difference in fistula procedures [IRR women versus men 0.96 (95% CI 0.85–1.07)]. Conclusion Compared with men, fewer women undergo a fistula attempt. This disparity increases after adjusting for comorbidities. Women have the same number of fistula procedures as men but are less likely to successfully use their fistula.
Pesticide residues in milk and their relationship with pesticide contamination of feedstuffs supplied to dairy cattle in Punjab (India)

The use of pesticides is indispensable to enhance the agricultural production and control vector-borne human and animal diseases. However, the inappropriate use of pesticides may lead to residues in concentrate feeds and fodder supplied to cattle especially when the withdrawal period is not respected (Rothwell et al., 2001). Also, animals may be exposed to pesticide residues during spraying with pesticide the cattle barn to avoid vector-borne diseases. In time of spraying, the water and feed should be well protected, unless the accidental spills may occur, which may result in feed and water contamination and the further pesticide ingestion by animals (Tsiplakou et al., 2010). Pesticides after entering ABSTRACT. The aim of the present study was to investigate the correlation between pesticides contamination of feedstuffs supplied to dairy cattle and pesticide residues in bovine milk. The animal concentrate feed, fodder, water and milk samples were collected from 55 dairy farms in Punjab (India) representing intensive production and typical feeding management. The concentrate feed, fodder/silage, water and milk samples were extracted by multiple residue methodology and pesticide residues concentration was estimated by gas chromatography. It was shown that chlorpyrifos pesticide was the main contaminant detected at mean level of 6.01, 4.05 and 2.58 ng · g−1 in concentrate feed, fodder and milk samples, respectively. Other pesticide residues observed in feed and milk samples were: endosulphan sulphate, cypermethrin, ethion, p,p’-DDE, lindane, malathion and fenvalerate. Chlorpyrifos was the only pesticide detected in one water sample. Though the mean residue levels of pesticides were substantially below the maximum residue limits (MRL), individually two milk samples exceeded the MRL value for lindane (1.0 ng · g−1) and three for DDT (20.0 ng · g−1) and chlorpyrifos (20.0 ng · g−1). Two milk samples also violated the MRL value (10.0 ng · g−1) for endosulphan sulphate residues. However, none of the samples was found above the MRL (50.0 ng · g−1) for cypermethrin. The relationship between occurrence of pesticide residues in feedstuff and milk might suggest that animal feed is the main source for appearance of pesticides in milk. However, environmental contamination with pesticides, lack of good management practices while using pesticides and violation of withdrawal period for ectoparasiticides may also result in the occurrence of pesticide residues in milk. Received: 10 October 2016 Revised: 3 November 2017 Accepted: 15 January 2018
Determination of the Thermodynamics of B-lactoglobulin Aggregation Using Ultra Violet Light Scattering Spectroscopy

The problem of protein aggregation is widely studied across a number of disciplines, where understanding the behaviour of the protein monomer, and its behaviour with co-solutes is imperative in order to devise solutions to the problem. Here we present a method for measuring the kinetics of protein aggregation based on ultra violet light scattering spectroscopy (UVLSS) across a range of NaCl conditions. Through measurement of wavelength dependant scattering and using the model protein β-lactoglobulin, it is possible to isolate the thermodynamic contributions to thermal unfolding. We show that increasing NaCl concentration decreases the free energy of unfolding which is dominated by the decrease of the enthalpy contribution. This contribution is significantly larger than the decrease in change in entropy observed at higher salt concentrations between the folded and unfolded states.
Resolving the Kinematics and Moment Release of Early Afterslip Within the First Hours Following the 2016 Mw 7.1 Kumamoto Earthquake: Implications for the Shallow Slip Deficit and Frictional Behavior of Aseismic Creep

As stresses following rupture are dissipated continuous measurements of postseismic surface deformation provide insight into variations of the frictional strength of faults and the rheology of the lower crust and upper mantle. Due to the difficulty of capturing the earliest phase of afterslip, most analyses have focused on understanding postseismic processes over timescales of weeks to years. Here we investigate the kinematics, moment release, and frictional properties of the earliest phase of afterslip within the first hours following the 2016 Mw 7.1 Kumamoto earthquake using a network of 5‐minute sampled continuous Global Positioning System (GPS) stations. Using independent component analysis to filter the GPS data, we find that (1) early afterslip contributes only ~1% of total moment release within the first hour and 8% after 24 hr. This suggests that the lack of a coseismic slip deficit, which we estimate using standard geodetic data sets (e.g., InSAR, GPS, and pixel offsets) and which span the first 4 days of the postseismic period, is largely reflective of the dynamic rupture process and we can rule out contamination of moment release by early afterslip. (2) Early afterslip shows no evidence of a delayed nucleation or acceleration phase, where instead fault patches transition to immediate deceleration following rupture that is consistent with frictional relaxation under steady state conditions with dependence only on the sliding velocity. (3) There is a close correlation between the near‐field aftershocks and afterslip within the first hours following rupture, suggesting afterslip may still be an important possible triggering mechanism during the earliest postseismic period.