Miracle-dz/UniFAR-FTUs huggingface dataset:
Artificial Intelligence for context-aware surgical guidance in complex robot-assisted oncological procedures: an exploratory feasibility study

Background: Complex oncological procedures pose various surgical challenges including dissection in distinct tissue planes and preservation of vulnerable anatomical structures throughout different surgical phases. In rectal surgery, a violation of dissection planes increases the risk of local recurrence and autonomous nerve damage resulting in incontinence and sexual dysfunction. While deep learning-based identification of target structures has been described in basic laparoscopic procedures, feasibility of artificial intelligence-based guidance has not yet been investigated in complex abdominal surgery. Methods: A dataset of 57 robot-assisted rectal resection (RARR) videos was split into a pre-training dataset of 24 temporally non-annotated videos and a training dataset of 33 temporally annotated videos. Based on phase annotations and pixel-wise annotations of randomly selected image frames, convolutional neural networks were trained to distinguish surgical phases and phase-specifically segment anatomical structures and tissue planes. To evaluate model performance, F1 score, Intersection-over-Union (IoU), precision, recall, and specificity were determined. Results: We demonstrate that both temporal (average F1 score for surgical phase recognition: 0.78) and spatial features of complex surgeries can be identified using machine learning-based image analysis. Based on analysis of a total of 8797 images with pixel-wise target structure segmentations, mean IoUs for segmentation of anatomical target structures range from 0.09 to 0.82 and from 0.05 to 0.32 for dissection planes and dissection lines throughout different phases of RARR in our analysis. Conclusions: Image-based recognition is a promising technique for surgical guidance in complex surgical procedures. Future research should investigate clinical applicability, usability, and therapeutic impact of a respective guidance system.
Digital Digital A genome-wide meta-analysis of association studies of A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales Cloninger's Temperament Scales

Temperament has a strongly heritable component, yet multiple independent genome-wide studies have failed to identify signiﬁcant genetic associations. We have assembled the largest sample to date of persons with genome-wide genotype data, who have been assessed with Cloninger’s Temperament and Character Inventory. Sum scores for novelty seeking, harm avoidance, reward dependence and persistence have been measured in over 11 000 persons collected in four different cohorts. Our study had 4 80% power to identify genome-wide signiﬁcant loci ( P o 1.25 (cid:2) 10 (cid:3) 8 , with correction for testing four scales) accounting for X 0.4% of the phenotypic variance in temperament scales. Using meta-analysis techniques, gene-based tests and pathway analysis we have tested over 1.2 million single-nucleotide polymorphisms (SNPs) for association to each of the four temperament dimensions. We did not discover any SNPs, genes, or pathways to be signiﬁcantly related to the four temperament dimensions, after correcting for multiple testing. Less than 1% of the variability in any temperament dimension appears to be accounted for by a risk score derived from the SNPs showing strongest association to the temperament dimensions. Elucidation of genetic loci signiﬁcantly inﬂuencing temperament and personality will require potentially very large samples, and/or a more reﬁned phenotype. Item response theory methodology may be a way to incorporate data from cohorts assessed with multiple personality instruments, and might be a method by which a large sample of a more reﬁned phenotype could be acquired.
M ODELLING OF I NTERFACIAL F LOWS B ASED ON A N E XPLICIT V OLUME D IFFUSION C ONCEPT

A novel volume of ﬂuid model (VoF) called explicit volume diffusion (EVD) is developed for the simulation of interfacial ﬂows, including those with turbulence and primary spray atomisation. The EVD model is derived by volume averaging the VoF equations over a physically-deﬁned length scale. This introduces unclosed sub-volume ﬂux, sub-volume stress and volume averaged surface tension force. Sub-volume ﬂuctuations arise due to both turbulent motions and other interface dynamics which can, in general, occur in both laminar and turbulent ﬂows. Both of these types of ﬂuctuations are attenuated by the volume averaging process. The sub-volume ﬂux is closed by a gradient diffusion model and involves an explicit volume diffusion coefﬁcient that is linked to the physical length scale. The sub-volume stress closure introduces an explicit volume viscosity augmented by turbulent viscosity in turbulent ﬂows. The volume averaged surface tension force closure is based on fractal properties of wrinkled sub-volume interfaces. These closures are evaluated through a priori analysis of resolved ﬂow simulations for a series of two-dimensional laminar and three-dimensional turbulent interfacial shear ﬂows. Subsequently, full EVD simulations are validated for these shear ﬂows and for a laboratory airblast spray jet. Numerical convergence is demonstrated by keeping the physical length scale constant while reducing the numerical grid size so that numerical diffusion diminishes and becomes overwhelmed by the explicit volume diffusion. A sensitivity analysis is also conducted for variations in the physical length scale, which is compared to the boundary layer thickness on the light ﬂuid side of the interface.
Psychological interventions for adult PTSD: A network and pairwise meta-analysis of short and long-term efficacy, acceptability and trial quality

While dozens of randomized controlled trials (RCTs) have examined psychological interventions for adult posttraumatic stress disorder (PTSD), no network meta-analysis has comprehensively integrated their results for all interventions and both short and long-term efficacy. We conducted systematic searches in bibliographical databases to identify RCTs comparing the efficacy (standardized mean differences in PTSD severity, SMDs) and acceptability (relative risk of all-cause dropout, RR) of trauma-focused cognitive behaviour therapy (TF-CBT), Eye Movement Desensitization and Reprocessing (EMDR), other trauma-focused psychological interventions (other-TF-PIs) and non-trauma-focused psychological interventions (non-TF-PIs) compared to each other or to passive or active control conditions. Hundred-fifty RCTs met inclusion criteria comprising 11,282, 4,443 and 3,167 patients at post-treatment assessment, [≤] 5 months follow-up and > 5 months follow-up, respectively. By far the most data exist for TF-CBT. We performed random effects network meta-analyses (efficacy) and pairwise meta-analyses (acceptability). All therapies produced large effects compared to passive control conditions (SMDs [≥] 0.80) at post-treatment. Compared to active control conditions, TF-CBT and EMDR were moderately more effective (SMDs [≥] 0.50 < 0.80), and other-TF-PIs and non-TF-PIs were slightly more effective (SMDs [≥] 0.20 < 0.50). Interventions did not differ in their short-term efficacy, yet TF-CBT was more effective than non-TF-PIs (SMD = 0.14). Results remained robust in sensitivity and outlier-adjusted analyses. Similar results were found for long-term efficacy. Interventions also did not differ in terms of their acceptability, except for TF-CBT being associated with a slightly increased risk of dropout compared to non-TF-PIs (RR=1.34; 95% CI: 1.05-1.70). Interventions with and without trauma focus appear effective and acceptable in the treatment of adult PTSD with most certainty for TF-CBT, which, however, appears somewhat less acceptable than non-TF-PIs.
Immunogenicity of BNT162b2 Vaccine Booster Dose in Patients With Inflammatory Bowel Disease Receiving Infliximab Combination Therapy: A Prospective Observational Study

Introduction Few data exist regarding the immunogenicity of the third dose of BNT162b2 relative to the second dose in patients with inflammatory bowel disease (IBD) on different immunosuppressive therapies. We investigated the immunogenicity of BNT162b2 vaccine booster dose in patients with IBD on infliximab combination therapy. Method This is a prospective single-center observational study conducted from January 1, 2022 to February 28, 2022. Patients were recruited at the time of attendance at the infusion center. Eligibility criteria included patients with a confirmed diagnosis of IBD who are receiving infliximab with azathioprine or 6-mercaptopurine. Patients who received two doses of BNT162b2 vaccine (second dose group) were compared to patients who had received three doses of BNT162b2 vaccine [third dose (booster) group]. Patients were excluded if they were infected or had symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) previously since the start of the pandemic or received other vaccines than the BNT162b2. Our primary outcome was the concentrations of SARS-CoV-2 antibodies Immunoglobulin G (IgG) and neutralizing antibodies 40–45 weeks from the first dose of BNT162b2 vaccine in patients with IBD receiving infliximab combination therapy. Medians with interquartile range (IQR) were calculated. Results In total, 162 patients with IBD and receiving infliximab combination therapy were recruited, and the number of patients in both the second dose group and third dose (booster) group was 81. Mean age was 35 years old in both groups. Median (IQR) SARS-CoV-2 IgG levels were significantly lower after the second dose [125 BAU/ml (43, 192)] compared to patients who received the third booster dose [207 BAU/ml (181, 234)] (P = 0.003). Neutralizing antibody levels were also lower after the second dose [80% (21, 95)] compared to patients who received the third booster dose [96% (93, 99)] (P ≤ 0.001). The percentage of patients who achieved positive SARS-CoV-2 IgG levels in the third (booster) dose group was 96.3%, whereas it was 86.4% in the second dose group. The percentage of participants who received the third (booster) dose and achieved a positive SARS-CoV-2-neutralizing antibody level was 100%, whereas it was 88.9% in the participants who received the second dose only. Conclusion Most patients with IBD on infliximab combination therapy had positive SARS-CoV-2 IgG and neutralizing antibody concentrations 40–45 weeks post BNT162b2 vaccination. However, SARS-CoV-2 IgG and neutralizing antibody concentrations were lower in patients who received two doses only compared to patients who received a third dose. A longer follow-up study is needed to evaluate decay in antibodies over time.
Improving the production of barley genotypes by foliar application of micronutrients

A field experiment on “improving the production of barley genotypes by foliar application of micronutrients” was carried out at Agronomy Research Farm, The University of Agriculture, Peshawar, Khyber Pakhtunkhwa-Pakistan, during 2013-14. Two barley genotypes [G1=2-Row barley and G2=6-Row barley] and foliar application of two micronutrients Zn and Cu [MN1=Control (water spray), MN2=4 kg Zn ha-1, MN3=1.0 kg Cu ha-1, MN4=4 kg Zn ha-1 + 1.0 kg Cu ha-1] were tested in the experiment. The experiment was laid out in a randomized complete block design (RCBD) replicated three times. The plot size 1.8m x 3m, having 30 cm row to row distance was used. Results evaluated that 2-row barely produced maximum numbers of tillers plant-1 (7), plant height (98.9 cm), long spikes (9.1cm), and thousand grains weight (52.5 g), while 6-row was efficient to produced more grains spike-1 (54) and grain yield (3990 kg ha-1). Application of micronutrients revealed that combine application of zinc and copper improved yield and yield components of barley. Maximum tillers plant-1 (7), plant height (92.3 cm), spike length (9.0 cm), grains spike-1 (44), thousand grains weight (53.8g) and grain yield (3934kg ha-1) was produced by combine application of Zn and Cu followed by sole Zn application as compared to control. Therefore it can be concluded from the results that 6-row barley performed better in terms of grain yield and combine application of Zn and Cu enhanced all yield components. Keywords: Barley (Hordeum vulgare L.); Genotypes; Micronutrients; Yield and yield components http://dx.doi. org/10.19045/bspab.2017. 60025
Evidence Quality Assessment of Tai Chi Exercise Intervention in Cognitive Impairment: An Overview of Systematic Review and Meta-Analysis

Background Tai Chi (TC) exercise has recently received wide attention for its efficacy in the management of cognitive impairment. The purpose of this overview is to summarize the available evidence on TC treatment of cognitive impairment and assess its quality. Methods We retrieved relevant systematic reviews/meta-analyses (SRs/MAs) from 7 databases from the time they were established to January 2, 2022. Two reviewers independently evaluated the methodological quality, risk of bias, report quality, and evidence quality of the included SRs/MAs on randomized controlled trials (RCTs). The tools used are Assessment System for Evaluating Methodological Quality 2 (AMSTAR-2), the Risk of Bias In Systematic (ROBIS) scale, the list of Preferred Reporting Items for Systematic Reviews And Meta-Analysis (PRISMA), and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. Results This overview finally included 8 SRs/MAs. According to the results of AMSTAR-2, all included SRs/MAs were rated as very low quality. Based on the ROBIS tool, none of the SR/MA had a low risk of bias. In light of PRISMA, all SRs/MAs had reporting deficiencies. According to the GRADE system, there was only 1 high-quality piece of evidence. Conclusion TC is a promising complementary and alternative therapy for cognitive impairment with high safety profile. However, in view of the low quality of the included SRs/MAs supporting this conclusion, high-quality evidence with a more rigorous study design and a larger sample size is needed before making a recommendation for guidance.
The Interaction Effect Between Previous Stroke and Hip Fracture on Postoperative Mortality: A Nationwide Cohort Study

Purpose It remains uncertain how a history of stroke impacts the prognosis for patients with hip fracture. This study aimed to evaluate mortality following hip fracture surgery by comparing patients with and without a history of stroke. Patients and Methods All patients aged 65 years or above in Denmark receiving hip fracture surgery between 2010 and 2018. For every patient, 10 individuals from the general population without hip fracture were sampled. Comparators had a similar stroke history, age, and sex on the date of hip fracture surgery (index date). We established four cohorts: hip fracture patients with/without stroke and non-hip fracture patients with/without stroke. Outcomes were all-cause mortality at 0–30 days, 31–365 days and 1 to 5 years. Direct standardized mortality rates (MR) with 95% confidence intervals (CI) were computed. We calculated the interaction contrast to estimate excess absolute mortality among patients with both hip fracture and stroke. Through a Cox proportional hazards model, we estimated the hazard ratio (HR) and the attributable proportion as a measure of excess relative mortality attributable to interaction. Results Of the hip fracture patients, 8433 had a stroke history and 44,997 did not. Of the non-hip fracture patients, 84,330 had a stroke history and 449,962 did not. Corresponding 30-day MRs/100 person years were 148.4 (95% CI: 138.8–158.7), 124.3 (95% CI: 120.7–128.1), 14.3 (95% CI: 13.4–15.2) and 8.4 (95% CI: 8.1–8.7). The interaction contrast was 18.2 (95% CI: 7.5–28.8), and the attributable proportion was 9.0% (95% CI: 2.9–15.1). No interaction was present beyond 30 days. Conclusion We observed excess short-term mortality in patients with stroke and hip fracture, but the effect disappeared at later follow-up periods. Clinicians are encouraged to pay rigorous attention to early complications among hip fracture patients with stroke, as this may serve as a way to reduce mortality.
Glioblastoma: Pitfalls and Opportunities of Immunotherapeutic Combinations

Abstract Glioblastoma multiforme (GBM) is the most common and aggressive primary central nervous system tumour in adults. It has extremely poor prognosis since the current standard of care, comprising of gross total resection and temozolomide (TMZ) chemoradiotherapy, prolongs survival, but does not provide a durable response. To a certain extent, this is due to GBM’s heterogeneous, hostile and cold tumour microenvironment (TME) and the unique ability of GBM to overcome the host’s immune responses. Therefore, there is an urgent need to develop more effective therapeutic approaches. This review provides critical insights from completed and ongoing clinical studies investigating novel immunotherapy strategies for GBM patients, ranging from the use of immune checkpoint inhibitors in different settings of GBM treatment to novel combinatorial therapies. In particular, we discuss how treatment regimens based on single antigen peptide vaccines evolved into fully personalised, polyvalent cell-based vaccines, CAR-T cell, and viral or gene therapies. Furthermore, the results of the most influential clinical trials and a selection of innovative preclinical studies aimed at activating the immunologically cold GBM microenvironment are reviewed.
Effect of Vitamin Supplementation on Egg Production, Egg Quality, and Mortality of Sasso Chickens

Introduction Ethiopia has a huge poultry population that plays a role in rural development. However, feed shortage is a major problem. Vitamin supplementation in feed formulation is crucial to improve the productivity of poultry. The objective of this study was to evaluate extra doses of vitamin supplements in quality egg production. Methods This experimental study was conducted on Sasso Ruby T chickens aged 22 weeks. The experimental and control groups each contained 60 hens. For the study group, extra doses of vitamins were added to the drinking water. Weekly observation was carried out for 3 months for a total of 12 observations. The effect of extra doses of vitamins on layers in terms of mortality, egg production, egg size, egg-specific gravity, and eggshell thickness was analyzed using SPSS 20 with t-tests. Results Significant changes were observed for mortality (P<0.05), with mean mortality of 0.25±0.45 and 0.66±0.65 and general mortality of 5% and 13% in the study and control groups, respectively. Average egg production per week in the study group (279.5±3.80) was significantly (P<0.05) higher than the control group (256±4.81). However, no significant difference (P>0.05) was found for egg size between the groups: study group 59.99±0.92 g and control group 59.34±0.95 g. There was no significant variation (P>0.05) in average egg-specific gravity: study group 1.068±5.33×10−3 and control group 1.061±5.33×10−3. Average eggshell thickness was significantly greater (P<0.05) in the study group(0.36±0.048 mm) than the control group (0.32±0.04 mm). Conclusion We identified that extra vitamin supplements for layer chickens is very important to increase profitability in the poultry industry by decreasing mortality and increasing egg production.
A study on the smart band, technologies, and case studies for the vulnerable group. - The Digital Age and the Fourth Industrial Revolution .

This study aims to study non-rechargeable wrist-type smart bands for those vulnerable to the digital environment. The transition to the digital age means improving the efficiency of human life and the convenience of management. In the digital age, it can be a very convenient infrastructure for the digital generation, but otherwise, it can cause inconvenience. COVID-19 is spreading non-face-to-face culture. The reality is that the vulnerable are complaining of discomfort in non-face-to-face culture. The core of the digital environment is smartphones. Digital life is spreading around smartphones. Technology that drives the digital environment is the core technology of the Fourth Industrial Revolution. The technologies are lot, big data, Blockchain, Smart Mobility, and AI. Related technologies based on these technologies include digital ID cards, digital keys, and nfc technologies. Non-rechargeable wrist-type smart bands based on related technologies can be conceptualized. Through these technologies, blind people can easily access books and manage their ID cards conveniently and efficiently. In particular, access authentication is required wherever you go due to COVID-19, which can be used as a useful tool for the elderly who feel uncomfortable using smartphones. It can also eliminate the inconvenience of the elderly finding or losing their keys.
Characteristics and Quality of Diagnostic and Risk Prediction Models for Frailty in Older Adults: A Systematic Review

Several prediction models for frailty in older adults have been published, but their characteristics and methodological quality are unclear. This review aims to summarize and critically appraise the prediction models. Studies describing multivariable prediction models for frailty among older adults were included. PubMed, Embase, Web of Science, and PsycINFO were searched from outset to Feb 21, 2021. Methodological and reporting quality of included models were evaluated by PROBAST and TRIPOD, respectively. All results were descriptively summarized. Twenty articles including 39 models were identified. The included models showed good predictive discrimination with C indices ranging from 0.70 to 0.98. However, all studies except one were assessed as high risk of bias mainly due to inappropriate analysis; meanwhile, poor reporting quality was also frequently observed. Few mature prediction models can be used in practice. Researchers should pay more attention to external validation and improving the quality both in methodology and reporting.
Weighted blankets for sleep problems – prescription, use and cost analysis

Abstract Background Weighted blankets (WBs) have been suggested as a treatment option for insomnia and are commonly prescribed despite lack of evidence of efficacy. Aim To investigate prescription pattern, return rate and cost of WBs. Material and methods This observational cohort register-based study in western Sweden included every individual who, in a 2.5-year period, was prescribed and received at least one WB (n = 4092). A cost evaluation was made by mapping prescription processes for WBs and sleep medication. Results Individuals diagnosed with dementia, anxiety, autism or intellectual disability (ID) retained the WB longer than others. Individuals younger than six and older than 65 years had shorter use time. The cost evaluation showed that the prescription process for WBs was longer and resulted in a higher cost than for sleep medication. Conclusions Some individuals had longer use time, indicating a possible benefit from using a WB. Due to low risk of harm but high economic cost, a revision of the WBs prescription process could be recommended to identify those who might benefit from WB. Significance Our result points towards a need for revision of the prescription process, to implement standardized sleep assessments, and create a more efficient prescription process to lower the cost.
Surface Electromyography: Physiology, engineering, and applications

Reflects on developments in noninvasive electromyography, and includes advances and applications in signal detection, processing and interpretation. Addresses EMG imaging technology together with the issue of decomposition of surface EMG Includes advanced single and multi-channel techniques for information extraction from surface EMG signals Presents the analysis and information extraction of surface EMG at various scales, from motor units to the concept of muscle synergies.