Miracle-dz/UniFAR-FTUs huggingface dataset:
Stable Instability of Sarcoma Cell Lines Genome Despite Intra-Tumoral Heterogeneity: A Genomic and Transcriptomic Study of Sarcoma Cell Lines

Background: Sarcoma oncogenesis is still poorly understood and functional studies are hampered by the dearth of cell lines representative of diverse sarcoma types. The existing models suffer from two main pitfalls: lack of representativeness of the tumors from which they were derived and lack of information about their evolution over passages. There is therefore a pressing need to generate new cell lines. Methods: All sarcoma tumors from patients receiving surgery in a large tertiary referral center in France were cultured to establish the corresponding cell lines. We performed comparative genomic and transcriptomic studies of the original tumor and cell lines to evaluate the representativeness of the cell line to the original tumor and evolution over passages. Results: Pleomorphic sarcomas are genetically heterogeneous. As a consequence, cell lines derived from that kind of tumor developed from selected clones roughly representing the initial tumor. More importantly, our results show that there are no genetic imbalances and transcription modifications along passages. Conclusion: Even if pleomorphic sarcomas are genetically unstable at the cellular level, they appear to be genetically stable at the multicellular one, and therefore remain representative of the initial tumor even after passages. We established a sarcoma cell line panel gathering 32 cell lines with genomic, transcriptomic and clinical data, which will be significant to understand genomic alterations, sarcoma biology and to manage preclinical studies and clinical trials.
The effects of MAPP and OPDC on physical and mechanical properties of OPDC-RPC

Oil palm decanter cake reinforced with polypropylene composite (OPDCRPC) was developed by varying the percentages of oil palm decanter cake (OPDC) and maleic anhydride polypropylene (MAPP). By adding MAPP, the mechanical properties (tensile, flexural and impact strength) had improved and the optimum mechanical strength was obtained at 30% OPDC due to strong internal bonding of OPDC and polymer. This evidence was captured using SEM where OPDC had a better bonding with MAPP. Water absorption test also confirmed the nature of hydrophilic properties of OPDC. To reduce the water absorption, MAPP was added and able to reduce the void inside OPDC-RPC material, hence reduced water penetration and water absorption rate. Muhammad Aqif Adam et. al. 84
Immediate Acetylene Reduction by Excised Grass Roots Not Previously Preincubated at Low Oxygen Tensions'

Excised roots of Spartuia akernaifora Loisel. and corn reduced acetylene in air without the previously reported period of zero activity lasting 8 to 18 hours. The profiles of acetylenedependent ethylene accumulation by ex- cised roots and intact plants of S. akeminflora were similar. No significant change in the number of bacteria associated with the roots was detectable during the assay. Most of the nitrogenase activity was detected in the roots and rhizomes of the plants. The salt marsh sediment also was capable of reducing acetylene. Additional damage to roots by washing and cutting increased the rate of acetylene reduction with samples incubated in air. Low concentrations of nitrate significantly inhibited the nitrogenase activity associated with the sediment and excised roots, but not with intact plants. Rates of acetylene reduction by excised corn roots were low. Oxidation and endogenous production of ethylene in the absence of acetylene were negligible. Measurements made with excised grass roots as described probably reflect the occurrence and magnitude of nitrogenase activity associated with the plants in the field.
Demolition and adaptation at the CB1 development, Cambridge

Cambridge is a historic city in the UK with an international reputation. The CB1 development is a major real estate regeneration project around the train station aiming to provide a gateway to the city. Once complete it will provide over 50,000 sq m of offices; 5,000 sq m of retail; 1,250 student units and 330 residential dwellings. When creating such a masterplan on a brown field site with multiple existing buildings and in a sensitive context, multiple decisions to demolish or adapt need to be made. This paper tracks the history of the CB1 development through a review of planning documentation and media articles, and through interviews with key stakeholders, including the developers, town planners, architects, engineers and local campaigners, identifying where and how key decisions relating to adaptation and demolition were made. The case study reveals complexities of decision-making in a real-world context. For example, for some of the existing buildings there were conflicting viewpoints about their future. The demolition of a Victorian terrace in favour of two new-build office blocks saw opposition from a local campaign group and the city councillors. However, the planning refusal was taken to appeal by the developers, who were then granted permission by the Planning Inspectorate. Arguments put forward included the lack of architectural significance, supported by the building not being listed and the public benefit brought about by demolition. The paper also explores the technical aspects associated with buildings which were demolished or retained through the creation and analysis of a database of existing and new buildings. The exploration builds upon international research analysing features that increase adaptation potential. Considering such aspects as, the condition of the building; floor to ceiling heights; standardised floor plates; and intangible values, such as architectural significance. The paper therefore assesses the CB1 development from both a technical and social perspective. The conclusions encourage actions to ensure holistic and sustainable decision-making in the future, recommending: the need for early stakeholder engagement; clarity on the strength of outline planning permission; and the recognition that heritage conservation and new build can both contribute to place-making. The paper also demonstrates the need for compromise, with inevitable conflicting viewpoints on a development of this scale.
Dynamic motion characteristics of a spherical copper particle in the break of SF
 6
 HVDCCB

The development of high-voltage direct current circuit breaker (HVDCCB) has progressed rapidly. One of the major reasons for the failure of a circuit breaker is the metallic particle contamination. An enhanced mathematical model is proposed to simulate the motion dynamics of a spherical copper particle in the break of sulphur hexafluoride (SF 6 ) HVDCCB. By linking COMSOL and MATLAB, the interaction between particle motion and electric field distribution and plastic random movement in the collision process is considered. The effects of voltage magnitude and particle size on the particle motion are discussed. By means of statistical methods, the obtained findings show that, as voltage magnitude decreases or particle size increases, the particle-anode collision frequency decreases, and the particle-anode collision region increases in the x -direction but decreases in the y -direction. The accuracy of the proposed model is verified by experimental observations via high-speed video camera.
Diagnostics of power setting sensor fault of gas turbine engines using genetic algorithm

ABSTRACT Gas path diagnostics is one of the most effective condition monitoring techniques in supporting condition-based maintenance of gas turbines and improving availability and reducing maintenance costs of the engines. The techniques can be applied to the health monitoring of different gas path components and also gas path measurement sensors. One of the most important measurement sensors is that for the engine control, also called the power setting sensor, which is used by the engine control system to control the operation of gas turbine engines. In most of the published research so far, it is rarely mentioned that faults in such sensors have been tackled in either engine control or condition monitoring. The reality is that if such a sensor degrades and has a noticeable bias, it will result in a shift in engine operating condition and misleading diagnostic results. In this paper, the phenomenon of a power-setting sensor fault has been discussed and a gas path diagnostic method based on a Genetic Algorithm (GA) has been proposed for the detection of power-setting sensor fault with and without the existence of engine component degradation and other gas path sensor faults. The developed method has been applied to the diagnostic analysis of a model aero turbofan engine in several case studies. The results show that the GA-based diagnostic method is able to detect and quantify the power-setting sensor fault effectively with the existence of single engine component degradation and single gas path sensor fault. An exceptional situation is that the power-setting sensor fault may not be distinguished from a component fault if both faults have the same fault signature. In addition, the measurement noise has small impact on prediction accuracy. As the GA-based method is computationally slow, it is only recommended for off-line applications. The introduced GA-based diagnostic method is generic so it can be applied to different gas turbine engines.
A 2.2-GHz Configurable Direct Digital Frequency Synthesizer Based on LUT and Rotation

This paper proposes a configurable direct digital frequency synthesizer (DDFS) based on the lookup-table (LUT)- rotation architecture. To break through the limitation of the single mode, the proposed DDFS is the first attempt which supports four-mode switching on chip. Taking the advantages of small LUT size and pipelined rotation, the DDFS achieves both high-speed and high-resolution properties. The multi-bit rotation tree is helpful to reduce the latency and register usage, which improves the agility and energy efficiency of the DDFS. A partition problem is raised in this paper, and we estimate the optimal solution through both the theory and experiment. Based on the partition, an output can achieve the highest spurious-free dynamic range (SFDR) with as small as possible LUT size. The functionality of the proposed DDFS has been validated in a Xilinx ZedBoard field-programmable gate array. The synthesis and layout results show that the chip achieves maximum 102-dBc SFDR and 2.2-GHz clock frequency. The power consumption and latency cycles reach minimum 6.9 mW/GHz and 7 cycles, which are 20% and 30% reduction compared with the state-of-the-art DDFS.
Applications of hyperspectral image analysis for precision agriculture

With world projections of global population running to 9.5-10 billion by mid-century, it has becoming apparent that increasing food production will soon become an existential problem. However, the world has been here before. In the mid 1950’s parts of the developing world, especially in Mexico and India were facing national food crises. This previous situation helped spark a series of innovations that collectively became known as the “Green Revolution. ” Recent advances in sensor technology, computer processing power, and algorithmic development have ushered in a new era of data-driven, precision farming. It is now possible to obtain precise measurements of biological phenomena on very large spatial and temporal scales. This development is part of a continuum of advances that have ushered in “Green Revolution 2.0” with Digital Farming technologies becoming the tip of the spear. In this paper we review the timeline and development of both biological and sensor technologies that are just now beginning to converge, with special emphasis on hyperspectral instrumentation. We address some very recent developments in the field and speculate about the potential of future advances to solve the pressing issue of adequate global food production.
CCIDE_A_261108 263..269

Faezeh Ghaderi Zahra Jowkar 2 Alireza Tadayon 1Oral and Dental Disease Research Center, Department of Pediatric Dentistry, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran; 2Oral and Dental Disease Research Center, Department of Operative Dentistry, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran; 3Department of Operative Dentistry, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran Aim: This study aimed to assess the relationship between preoperative pain status, caries extent, and caries color and the ability to achieve hemostasis at the canal orifices during pulp therapy access in primary teeth. Study Design: Eighty primary molar teeth with extremely deep caries extending to the pulp (based on bitewing radiography) were investigated in 66 children. The teeth with clear radiographic and clinical signs indicating the involvement of the radicular pulp were excluded. The history of preoperative pain status, the color of dental caries by visual inspection, and the extent of caries lesion measured in bitewing radiographs were recorded. After preparing the access cavities, the hemostasis achievement at the canal orifices was assessed and considered as the final factor in determining the type of treatment (pulpotomy or pulpectomy). The data were analyzed using Fisher’s exact test, the independent t-test, and Cohen’s unweighted kappa statistic. P<0.05 was considered statistically significant. Results: Hemostasis was achieved in 78.1% of the teeth with black dental caries, whereas in most of the teeth with light brown dental caries (64.3%), hemostasis was not achieved (p=0.015). The extent of dental caries in the teeth needing pulpotomy was statistically significantly lower than that of those needing pulpectomy (p=0.024). Mesial side dental caries was more related to the irreversible pulpitis compared to the distal one (p=0.01). In 78.1% of the teeth without pain, hemostasis was achieved, and in most of the teeth with nocturnal pain (64.3%), hemostasis did not occur (p=0.034). Conclusion: The caries color, caries extent, and preoperative pain have the potential to be used as clinical diagnostic tools to determine the pulpal status in primary teeth.
Review on role of geospatial technology in vegetation mapping, conservation and land use land cover analysis

- Population demands power generation and industrial applications for secure energy due to fulfilling basic requirements. It causes land cover changes; produces destruction of environment, geological resources and biological resources. This impact can be examined by using geospatial applications; remote sensing (RS) and geographical information system (GIS). Present review based on the role of geospatial technology in vegetation mapping, biodiversity conservation and land use land cover (LULC) analysis. This review focused on the utility of geospatial technology in vegetation mapping, in an analysis of land use land cover as well as the correlation between land cover change and destruction of biodiversity. However geological resources are the raw material of development, due to mankind cannot admit defeat on it. As per this paper, it is concluded that astute use of geological resources, ecological restoration, urban development planning and eco- friendly substitute and alternatives must provide the answer of sustainable development.
Antiviral therapy reduces MSL2 by downregulation of HBx, without direct effect on cccDNA level in patients with hepatocellular carcinoma

The covalently closed circular DNA (cccDNA) is an intermediate in the life cycle of HBV virus. HBV-encoded X protein (HBx), a key viral oncoprotein, can be specifically modified by E3 ubiquitin ligase, such as Male Specific Lethal 2 (MSL2), a process called ubiquitination that up-regulates HBx activity to promote transcription, cell proliferation and tumor growth. This study aimed to compare the cccDNA, MSL2 mRNA, and HBx mRNA levels in tumor and peri-tumor tissues, and to compare differences in cccDNA and MSL2 mRNA levels between HBx-positive and HBx-negative patients. Moreover, we clarified the impact of antiviral therapy on these indicators. PCR performed quantify cccDNA levels ware significantly higher in the tumor tissues than in peri-tumor tissues (44.68 ± 65.14 vs. 11.47 ± 23.03; p = 0.001). The cccDNA level in the tumor and peri-tumor tissues was significantly different, especially in the HBeAg positive group (90.07 ± 93.94 vs. 10.05 ± 10.48; p = 0.008), tumor recurrence group ( p = 0.002) and tumor size less than 3cm group ( p = 0.003). Moreover, in patients with preoperative cirrhosis, levels of cccDNA and MSL2 mRNA were significantly higher in tumor tissue than in peri-tumor tissue ( p < 0.001 and p = 0.023). The levels of HBx mRNA in tumor and peri-tumor tissues were significantly lower in the antiviral treated group than in untreated group (p = 0.026 and p = 0.035). The levels of cccDNA and MSL2 mRNA in the HBx positive group were significantly higher in tumor tissues than in peri-tumor tissues ( p = 0.026 and 0.013). Moreover, MSL2 mRNA levels were significantly higher in HBx-positive tumor tissues than in HBx-negative tumor tissues ( p = 0.002). However, there was no difference in cccDNA levels between HBx-positive tumor tissues and HBx-negative tumor tissues ( p = 0.609). higher modulate by reducing levels of HBx to inhibit the tumorigenic effect of MSL2 and cccDNA. activates HBV cccDNA in hepatoma cells to promote hepatocarcinogenesis, forming a HBx/MSL2/cccDNA/HBV positive feedback loop (13). This study aimed to compare the cccDNA, MSL2 mRNA, and HBx mRNA levels in tumor and peri-tumor tissues and
Content features and its implementation in novel app-based psycho-oncological interventions for cancer survivors: a narrative review

Purpose of review The interest in and availability of app-based psycho-oncological interventions for cancer survivors has grown rapidly. In this narrative review, we therefore aim to provide an overview of the psychological content features included in psycho-oncological apps and how the content is implemented in the apps. Recent findings A total of 19 studies (six randomized controlled trials, six studies with prepost design, five study protocols and two app developments), all published in the last 18 months (July 2020 to December 2021), were analyzed in terms of the described app-based interventions and their psycho-oncological content. Apps for cancer survivors are conducted for a variety of different diagnoses and often target a specific patient population, for example patients with a specific therapy. The most frequent content features are psychoeducation, self-monitoring of symptoms, and some sort of exercise or relaxation program. Depending on the app's purpose, some offer specific content, such as decision aids, medication schedules or modules to improve coping strategies. Most apps combine informative and interactive elements. Summary Psycho-oncological apps for cancer survivors target many relevant psychological problem areas and aim to improve patient empowerment. Available mHealth interventions can therefore be seen as a good complement for cancer care and also offer the possibility to improve patient involvement.
CHAPTER 4. Fine-scale mapping of the locus associated with eyespot size and colour composition in Bicyclus anynana

Butterfly eyespots are adaptive novelties perfectly suited for studies of the genetic and developmental basis of morphological evolution. Different types of genetic variation for eyespot patterns, including spontaneous mutations of large phenotypic effect, have been described in the lab model Bicyclus anynana . Analysis of such mutant alleles offers an opportunity to identify genes involved in formation of, and potentially contributing to variation in, these ecologically relevant traits. We have previously described three pleiotropic alleles at the BFS locus which affect the size and/or colour composition of eyespots and also disturb segment polarity in embryos. In this chapter, we used linkage mapping to test for association between several candidate genes from the Wnt/Wg signaling pathway, suggested previously by comparative analysis of embryonic defects, and the mutant phenotype. When all candidates were excluded, we used fine-scale mapping to identify the genomic region that contains the locus. We screened the genomic library, sequenced and annotated a single BAC clone, and subsequently refined the position of the locus to a ~34 kb interval. We characterized the genomic sequence in and around the BFS locus and identified 9 predicted genes in the implicated interval. None of these show homology to any known gene in any other organism. Also, analysis of the genomic region around this interval revealed that it contains genes with well-described functions, but none of them is related to Wnt/Wg signaling or pigment biosynthesis pathways. This implies novel, previously undescribed molecular mechanisms for eyespot determination in Bicyclus butterflies.
Smartphone-Based Telemedicine Supported by Pico-Satellite Constellation

ABSTRACT Many people in developing countries are required to travel for several hours to see a doctor. The concept of so called telemedicine accompanied with developments in the field of wireless communications may improve the health care. Here presented telemedicine system is for a distance consultation. It is based on a pocket smartphone using its camera to develop a video broadcasting mission for a real-time consultation. However, developing countries in the Middle East and North Africa suffer network coverage in most areas. To overcome this issue, the system includes a software defined radio in order to integrate the small satellite technology in the telemedicine routine. The proposed pico-satellite constellation can provide an interesting solution for near real-time transmission, which will significantly improve the health care in remote areas.
Is Open Government Aspect adopted in Local Development Planning?

, This paper aims to describes the Open Government aspect’s adoption in Local Government Development Planning. Open Government aspects is derived from [1] namely participation, transparency, and collaboration. Research design is using constructivist approach where using theory as a guidance for problem analyzing. This research is using qualitative method in data collecting technique, namely interview and document study. Data coding is processed with NVIVO version 12 plus besides data reduction and data display as a data analyzing method. Research result shows that Participation in development planning is showed with participation level on development planning at village level gradually decrease because citizen assume that program in planning and real program is not same. Transparency in development planning is showed with all program which from citizen is absorbed by local government at sub-district level. But, in local level, prioritize program which will be real program is discussed closely in local assembly building (close system). Collaboration in development planning is showed with several interest affected is involved in development planning with each interest. There is transparency guarantee in every development planning process, and ICT is the primary requirement for adopting open government’s aspects in ideal development planning. This research also recommends additional research linked open government, and the enrichment of participation and transparency concept.