Miracle-dz/UniFAR-FTUs huggingface dataset:
Beyond “Treatment Versus Control”: How Bayesian Analysis Makes Factorial Experiments Feasible in Education Research

Background: Researchers often wish to test a large set of related interventions or approaches to implementation. A factorial experiment accomplishes this by examining not only basic treatment–control comparisons but also the effects of multiple implementation “factors” such as different dosages or implementation strategies and the interactions between these factor levels. However, traditional methods of statistical inference may require prohibitively large sample sizes to perform complex factorial experiments. Objectives: We present a Bayesian approach to factorial design. Through the use of hierarchical priors and partial pooling, we show how Bayesian analysis substantially increases the precision of estimates in complex experiments with many factors and factor levels, while controlling the risk of false positives from multiple comparisons. Research design: Using an experiment we performed for the U.S. Department of Education as a motivating example, we perform power calculations for both classical and Bayesian methods. We repeatedly simulate factorial experiments with a variety of sample sizes and numbers of treatment arms to estimate the minimum detectable effect (MDE) for each combination. Results: The Bayesian approach yields substantially lower MDEs when compared with classical methods for complex factorial experiments. For example, to test 72 treatment arms (five factors with two or three levels each), a classical experiment requires nearly twice the sample size as a Bayesian experiment to obtain a given MDE. Conclusions: Bayesian methods are a valuable tool for researchers interested in studying complex interventions. They make factorial experiments with many treatment arms vastly more feasible.
Ocrelizumab Depletes CD20+ T Cells in Multiple Sclerosis Patients

Ocrelizumab, a humanized monoclonal anti-CD20 antibody, has shown pronounced effects in reduction of disease activity in multiple sclerosis (MS) patients and has recently been approved for the treatment of patients with relapsing MS (RMS) and primary progressive MS (PPMS). CD20 is mainly expressed by B cells, but a subset of T cells (CD3+CD20+ T cells) also expresses CD20, and these CD20+ T cells are known to be a highly activated cell population. The blood of MS patients was analyzed with multicolor flow cytometry before and two weeks after treatment with ocrelizumab regarding the phenotype of peripheral blood mononuclear cells. CD20-expressing CD3+ T cells were found in blood samples of all MS patients, accounted for 2.4% of CD45+ lymphocytes, and constituted a significant proportion (18.4%) of all CD20+ cells. CD3+CD20+ T cells and CD19+CD20+ B cells were effectively depleted two weeks after a single administration of 300 mg ocrelizumab. Our results demonstrate that treatment with ocrelizumab does not exclusively target B cells, but also CD20+ T cells, which account for a substantial amount of CD20-expressing cells. Thus, we speculate that the efficacy of ocrelizumab might also be mediated by the depletion of CD20-expressing T cells.
PEMODELAN KONTEKS DAN CONTEXT AWARENESS AVATAR DI DUNIA VIRTUAL

Konteks avatar perlu dimodelkan secara utuh sehingga dapat digunakan dalam beragam skenario dunia virtual yang dinamis. Tool pemodelan yang digunakan harus dapat meminimalisir ambiguitas penafsiran pada pengembangan sistem selanjutnya, sehingga digunakanlah Mocha, suatu tool spesifikasi berbasis Ambient Calculus dan UNITY. Mocha dikembangkan sehingga dapat mengekspresikan situasi dimana dua atau lebih konteks terjadi secara konkuren. Situasi konteks konkuren memiliki bentuk situasi konteks yang unik pada dunia virtual dan tidak dapat dimodelkan oleh notasi konteks primitif.
TEXT SIMILARITY COMPUTING BASED ON ATTRIBUTE THEORY

Generally, in the process of information retrieval(IR), the users first put forward their key words to the system that they want to search. Then the key words are analyzed to the special format, they are matched with the document database whose results are considered as the results that are related to the users' interests. There are several IR models, such as reverse document model, vector space model, generalized vector space model and latent semantic model and so on. According to attribute theory, this paper analyses the relationship between textual attributes and the attribute barycenter coordinate model, and establishes the text attribute barycenter coordinate model. Within the coordinate, a text vector and a query vector can be represented. After deciding the criterion and computing the distance between the vectors, a formula that computes the similarity between the texts and the queries is shown.
American Indian Historical Trauma: Anticolonial Prescriptions for Healing, Resilience, and Survivance

The American Indian historical trauma (HT) concept is an important precursor to racial trauma (RT) theory that reflects the distinct interests of sovereign Indigenous nations but shares much of the same promise and challenge. Here, that promise and challenge is explored by tracing HT’s theoretical development in terms of its anticolonial ambitions and organizing ideas. Three predominant modes of engaging HT were distilled form the literature (HT as a clinical condition, life stressor, and critical discourse), each informing a research program pursuing a different anticolonial ambition (healing trauma, promoting resilience, practicing survivance) organized by distinct ideas about colonization, wellness, and Indigeneity. Through critical reflection on these different ambitions and dialogue of their organizing ideas, conflict between research programs can be mitigated and a more productive anticolonialism realized in psychology and related health fields. Key recommendations emphasized clarifying clinical concepts (e.g., clinical syndrome vs. idiom of distress), disentangling clinical narratives of individual pathology (e.g., trauma) from social narratives of population adversity (e.g., survivance stories), attending to features of settler-colonialism not easily captured by heath indices (e.g., structural violence), and encouraging alignment of anticolonial efforts with constructive critiques establishing conceptual bridges to disciplines that can help to advance psychological understandings of colonization and Indigenous wellness (e.g., postcolonial studies). This conceptual framework was applied to the RT literature to elaborate similar recommendations for advancing RT theory and the interests of ethnic/racial minority populations through engagement with psychology and related health fields.
Mesenchymal stem cells in psoriatic lesions affect the skin microenvironment through circular RNA

Psoriasis is an autoimmune skin disease. Our previous studies revealed abnormal immune regulation of skin mesenchymal stem cells (S‐MSCs) in psoriatic lesions. Circular RNA (circRNA) molecules were recently discovered as a new class of non‐coding regulatory RNAs. Their role in the pathogenesis of psoriasis has not yet been studied. To explore potential circRNA‐mediated mechanisms of S‐MSCs in the pathogenesis of psoriasis, we sequenced mRNAs and circRNAs of MSCs from normal skin and psoriatic lesions, followed by functional prediction and interaction analyses. In total, 129 circRNAs were differentially expressed, including 123 up‐regulated and 6 down‐regulated circRNAs, in MSCs from psoriatic lesions. Pathway analysis showed that the genes significantly down‐regulated in psoriatic as compared to normal S‐MSCs were mainly involved in JAK‐STAT signalling. According to a circRNA‐miRNA‐mRNA interaction network, the expression of circRNAs associated with these mRNAs was also down‐regulated in MSCs of psoriatic skin lesions. Knockdown of the circRNA gene chr2:206992521|206994966 reduced the capacity of S‐MSCs to inhibit T‐cell proliferation upon co‐culture in normal as well as lesion‐derived S‐MSCs. Secreted‐cytokine profiles (IL‐6, IL‐11 and hepatocyte growth factor) were also similar in normal and lesion‐derived S‐MSCs after circRNA knockdown. Thus, the circRNA chr2:206992521|206994966 in S‐MSCs from psoriatic lesions affects the activity of T lymphocytes in local lesions by influencing their cytokine secretion. Taken together, our findings indicate that circRNA mediates the role of S‐MSCs in the pathogenesis of psoriasis.
Absenteeism and Presenteeism Associated With Common Health Conditions in Brazilian Workers

Background: This study describes the effects of common health conditions associated with absenteeism and presenteeism in a population-based sample of workers in Brazil. Methods: Data were analyzed from the cross-sectional São Paulo Megacity Mental Health Survey on 1737 employed residents aged more than 18 years old conducted from 2005 to 2007. Results: Physical diseases and mental disorders are highly prevalent among Brazilian workers. The prevalence of absenteeism was 12.8%, and the prevalence of presenteeism was 14.3%. The condition most commonly associated with work impairment was mood disorder. Conclusions: Improving access to care and increasing detection and management of mental disorders should be a priority in Brazil. Occupational health programs and services can play a key role in increasing the productivity of the Brazilian workforce.
Brain Metabolomics Reveal the Antipyretic Effects of Jinxin Oral Liquid in Young Rats by Using Gas Chromatography–Mass Spectrometry

Pyrexia is considered as a part of host's defense response to the invasion of microorganisms or inanimate matter recognized as pathogenic or alien, which frequently occurs in children. Jinxin oral liquid (JXOL) is a traditional Chinese medicine formula that has been widely used to treat febrile children in China. Experimental fever was induced by injecting yeast into young male Sprague-Dawley rats (80 ± 20 g) and the rectal temperature subsequently changed. Four hours later, the excessive production of interleukin (IL)-1β and prostaglandin (PG) E2 induced by yeast was regulated to normal by JXOL administration. A rat brain metabolomics investigation of pyrexia of yeast and antipyretic effect of JXOL was performed using gas chromatography-mass spectrometry (GC-MS). Clear separation was achieved between the model and normal group. Twenty-two significantly altered metabolites were found in pyretic rats as potential biomarkers of fever. Twelve metabolites, significantly adjusted by JXOL to help relieve pyrexia, were selected out as biomarkers of antipyretic mechanism of JXOL, which were involved in glycolysis, purine metabolism, tryptophan mechanism, etc. In conclusion, the brain metabolomics revealed potential biomarkers in the JXOL antipyretic process and the associated pathways, which may aid in advanced understanding of fever and therapeutic mechanism of JXOL.
Japan Wine, its characteristics and research

ABSTRACT A new rule stipulates that wine made in Japan from grapes harvested in Japan be labeled as “Japan wine”. The main grape varieties for Japan Wine, Koshu for white wine and Muscat Bailey A for red, are unique to Japan. Koshu is native to Japan and its origin, long unknown, has recently been revealed through DNA analysis. Wine made from this variety suffered from a lack of characteristic aroma, but a recent study has demonstrated its potential for producing wine with a citrus scent. Muscat Bailey A was bred in Japan. Its characteristic sweet aroma has been identified as being due to furaneol. Another characteristic of its wine is that it has a low concentration of proanthocyanidins (condensed tannin), and the reason for this was revealed recently. These and other studies have been conducted in wine companies, universities, and research institutes in Japan and support the development of Japan Wine. Abbreviations: SSR: simple sequence repeat; SNP: single nucleotide polymorphism; 3MH: 3-mercaptohexan-1-ol; 4-HDMF: 4-hydroxy-2,5-dimethyl-3(2H)-furanone; PCA: principal component analysis Graphical Abstract DNA analysis revealed the origin of Koshu, the most important white wine variety in Japan. It has a potential to produce wine with citrus aroma.
Using English Songs Minilyrics Collaboration To Improve Student’s Pronunciation In LPKM Mitra English Course JatinomIn 2011/ 2012 Academic Year

This research aims at knowing (1) the application of English songs MiniLyrics collaboration in teaching and learning pronunciation process, (2) describing English songs MiniLyrics collaboration improve student’s pronunciation. This research was implemented in LPKM Mitra English Course Jatinom, at the beginner class using classroomaction research. The methods of collecting the data are observation, interview, documentation (examining), and test. The researcher taught English pronunciation using English songs MiniLyrics Collaboration. To analyze the data the researcher compared the results of pre-test and post-tests using descriptive comparative and critical analytic technique. English songs MiniLyrics collaboration was implemented in three cycles with each cycle consisting of four steps. By implementing English songs Minilyrics collaboration in teaching pronunciation, the students can pronounce English words better. The students’ achievement of pronunciation is improved. It can be seen from the result of the students’ activities during the action and the students’ pronunciation achievement. The mean of pre-test is 58.90, post-test 100 and the improvement result of the implementation is 41.10%. The result of pretest and post- test showed the significant improvement. The chairman and English teacher said that this technique and media gave good effects in English learning. Most of the students said that they love this way. The students’ motivated to practice easily learn English pronunciation. Thus, it enables them pronouncing the words correctly. Third, it has more strengths than it weaknesses. So, using English songs MiniLyrics collaboration is successful to improve the students’s pronunciation.
Usability Evaluation of a Mobile Phone–Based System for Remote Monitoring and Management of Chemotherapy-Related Side Effects in Cancer Patients: Mixed-Methods Study

Background As most chemotherapy is administered in the outpatient setting, patients are required to manage related side effects at home without direct support from health professionals. The Advanced Symptom Management System (ASyMS) has been developed to facilitate the remote monitoring and management of chemotherapy-related toxicity in patients with cancer, using patient-reported outcomes questionnaires and a clinician alerting system. Objective This study aims to evaluate the usability of the ASyMS, a mobile phone–based technology, from the perspective of Canadian patients with cancer receiving chemotherapy to identify existing design, functionality, and usability issues and elicit their views, experiences, and satisfaction with the ASyMS. Methods We used a mixed-method approach to data collection with user-based testing, a think-aloud technique, semistructured interviews, and short answer questionnaires with a purposive sample of 10 patients with cancer. Participants attended usability testing sessions at the Centre for Global eHealth Innovation, University Health Network, and performed specific tasks on the ASyMS device. The test was videorecorded and each task was timed during the test. After the usability sessions, participants completed a posttest questionnaire and participated in a semistructured qualitative interview. A thematic analysis was used to code and categorize the identified issues into themes that summarized the type and frequency of occurrence. Results The thematic analysis generated 3 overarching themes as follows: ASyMS user-friendliness; usefulness of ASyMS (content quality and richness); and intention to use. Results from the posttest questionnaire indicated that 80% (8/10) of participants had great motivation to use the ASyMS, 70% (7/10) had positive perceptions of the successful use of the ASyMS, and all (10/10, 100%) had a positive attitude toward using the ASyMS in the future. Most identified design and functionality issues were related to the navigation of the ASyMS device and a desire for a more attractive design with advanced functionality and features. The main general design recommendations were as follows: enhance the readability of the screen; implement advance options (eg, search option); and support better navigation. Conclusions The ASyMS has shown positive perceptions of patients in usability testing and qualitative interviews. An evaluation of the effects of the ASyMS on symptom outcomes in a clinical trial is needed.
Solid Phase Microextraction: Apparatus, Sorbent Materials, and Application

Abstract The primary objective of this review article is to strategically screen and highlight the advancements in the area of solid phase microextraction (SPME). The plenty of review articles have been written on different aspects of SPME, this review is dedicated to provide the brief but clear overview of the research footprints so produced from SPME. Some of the key advancements in types and designs, coating materials, coating strategies, in vivo sampling and direct coupling of SPME with MS have been critically discussed.
From the Battlefield to Main Street: Tourniquet Acceptance, Use, and Translation from the Military to Civilian Settings.

Throughout history, battlefield medicine has led to advancements in civilian trauma care. In the most recent conflicts of OEF/OIF, one of the most important advances is increasing use of point-of-injury hemorrhage control with tourniquets. Tourniquets are gradually gaining acceptance in the civilian medical world-in both the prehospital setting and trauma centers. An analysis of EMS data shows an increase of prehospital tourniquet utilization from 0 to nearly 4,000 between 2008 and 2016. Additionally, bystander educational campaigns such as the Stop the Bleed program is expanding, now with over 125,000 trained on tourniquet placement. As the medical community and the population at large has broader acceptance and training on the use of tourniquets, there is greater potential for saving lives from preventable hemorrhagic deaths.
Bioinformatic analysis of long-lasting transcriptional and translational changes in the basolateral amygdala following acute stress

Stress profoundly impacts the brain and increases the risk of developing a psychiatric disorder. The brain’s response to stress is mediated by a number of pathways that affect gene expression and protein function throughout the cell. Understanding how stress achieves such dramatic effects on the brain requires an understanding of the brain’s stress response pathways. The majority of studies focused on molecular changes have employed repeated or chronic stress paradigms to assess the long-term consequences of stress and have not taken an integrative genomic and/or proteomic approach. Here, we determined the lasting impact of a single stressful event (restraint) on the broad molecular profile of the basolateral amygdala complex (BLC), a key brain region mediating emotion, memory and stress. Molecular profiling performed thirty days post-restraint consisted of small RNA sequencing, RNA sequencing and quantitative mass spectrometry and identified long-lasting changes in microRNA (miRNA), messenger RNA (mRNA) and proteins. Alignment of the three datasets further delineated the regulation of stress-specific pathways which were validated by qPCR and Western Blot analysis. From this analysis, mir-29a-5p was identified as a putative regulator of stress-induced adaptations in the BLC. Further, a number of predicted mir-29a-5p targets are regulated at the mRNA and protein level. The concerted and long-lasting disruption of multiple molecular pathways in the amygdala by a single stress event is expected to be sufficient to alter behavioral responses to a wide array of future experiences, including exposure to additional stressors.
A Child with Early-Onset Gorham-Stout Disease Complicated by Chylothorax: Near-Complete Regression of Bone Lesions with Interferon and Bisphosphonate Treatment

We report a case of Gorham-Stout disease (GSD) complicated by chylothorax and treated with a combination therapy with interferon and bisphosphonates. This treatment may be helpful in improving the usually unfavorable prognosis of GSD beginning with a chylothorax before 1 year of age, and in reducing bone lesions. Moreover, the use of bisphosphonates appears to be useful in treating pain.
An investigation of the effect of experimental pain on logical reasoning

Abstract Pain disrupts attention to prioritise avoidance of harm and promote analgesic behaviour. This could in turn have negative effects on higher-level cognitions, which rely on attention. In the current article, we examined the effect of thermal pain induction on 3 measures of reasoning: the Cognitive Reflection Test, Belief Bias Syllogisms task, and Conditional Inference task. In experiment 1, the thermal pain was set at each participant's pain threshold. In experiment 2, it was set to a minimum of 44°C or 7/10 on a visual analogue scale (whichever was higher). In experiment 3, performance was compared in no pain, low-intensity pain, and high-intensity pain conditions. We predicted that the experience of pain would reduce correct responding on the reasoning tasks. However, this was not supported in any of the 3 studies. We discuss possible interpretations of our failure to reject the null hypothesis and the importance of publishing null results.
Transcriptogramer: an R/Bioconductor package for transcriptional analysis based on protein-protein interaction

Motivation Several freely available tools perform analysis using algorithms developed to identify significant variation of gene expression individually. The transcriptogramer R package uses protein-protein interaction to perform differential expression of functionally associated genes. The software assesses expression profile of entire genetic systems and reveals which biological systems are significantly altered in case-control designed transcriptome experiments. Results R/Bioconductor transcriptogramer package projects expression values on an ordered gene list to perform topological analysis, differential expression, and Gene Ontology enrichment analysis, independently of data platform or operating system. Availability http://bioconductor.org/packages/transcriptogramer. Supplementary information Supplementary data are available at Bioinformatics online.
Association of antepartum vitamin D deficiency with postpartum depression: a clinical perspective

Abstract Objective Postpartum depression affects up to 20 % of new mothers within the first 12 months of parturition. 25-Hydroxyvitamin D (25(OH)D) has known importance in bone health, but it may also play an important role in other functions, including reproduction and fertility, immune function and mental health. This clinical commentary reviews literature evaluating 25(OH)D deficiency during pregnancy and the incidence of postpartum depressive symptomatology. Design Narrative review, summary and recommendations. Setting/Participants A literature search revealed five relevant studies of antepartum women, three based in the USA, one in Turkey and one in Iran. Results Three of the five studies measured serum 25(OH)D concentrations during the first or second trimester and discovered an association with 25(OH)D deficiency and depressive symptoms postpartum. One study determined an almost significant (P=0·058) inverse relationship with first-trimester 25(OH)D concentration and depressive symptoms postpartum, and the last study, which was a secondary analysis, did not find an association. Conclusions The Endocrine Society recommends routine vitamin D supplementation during pregnancy and lactation due to increased metabolic demand in the mother, but a recent Cochrane review recommended against screening. Vitamin D should be the target of more studies during pregnancy and the postpartum period since it appears to have an important role for both medical and mental health. Vitamin D supplementation is a relatively safe and cost-effective intervention during pregnancy, and it may prove to be important in the prevention of postpartum depression.