Miracle-dz/UniFAR-FTUs huggingface dataset:
Analytic nonlinear H∞ inverse-optimal control for Euler-Lagrange system

The success in nonlinear H/sub /spl infin// control design is applied to the control of Euler-Lagrange systems. It is known that the existence of H/sub /spl infin// optimal control depends on solvability of the so-called Hamilton-Jacobi-Isaacs H/sub /spl infin// partial differential equation. In the article, the associated HJI equation for nonlinear H/sub /spl infin// inverse-optimal control problem for a Euler-Lagrangian system is solved analytically. The resulting control is referred to as the reference error feedback, which takes conventional PID controller form. Consequently, robust motion control can be designed for robot manipulators using L/sub 2/-gain attenuation from exogenous disturbance and parametric error.
Constructive setting for problems of density ratio estimation

We introduce a constructive setting for the problem of density ratio estimation through the solution of a multidimensional integral equation. In this equation, not only its right hand side is approximately known, but also the integral operator is approximately defined. We show that this ill‐posed problem has a rigorous solution and obtain the solution in a closed form. The key element of this solution is the novel V‐matrix, which captures the geometry of the observed samples. We compare our method with previously proposed ones, using both synthetic and real data. Our experimental results demonstrate the good potential of the new approach.
A review of bibliometric and other science indicators and their role in research evaluation

Recent reductions in research budgets have led to the need for greater selectivity in resource allocation. Measures of past performance are still among the most promising means of deciding between competing interests. Bibliometry, the mea surement of scientific publications and of their impact on the scientific community, assessed by the citations they attract, provides a portfolio of indicators that can be combined to give a useful picture of recent research activity. In this state-of-the- art review the various methodologies that have been developed are outlined in terms of their strengths, weaknesses and par ticular applications. The present limitations of science indica tors in research evaluation are considered and some future directions for developments in techniques are suggested.
Exploiting cognitive radios for reliable satellite communications

Satellite transmissions are prone to both unintentional and intentional RF interference. Such interference has significant impact on the reliability of packet transmissions. In this paper, we make preliminary steps at exploiting the sensing capabilities of cognitive radios for reliable satellite communications. We propose the use of dynamically adjusted frequency hopping (FH) sequences for satellite transmissions. Such sequences are more robust against targeted interference than fixed FH sequences. In our design, the FH sequence is adjusted according to the outcome of out‐of‐band proactive sensing, carried out by a cognitive radio module that resides in the receiver of the satellite link. Our design, called out‐of‐band sensing‐based dynamic FH, is first analyzed using a discrete‐time Markov chain (DTMC) framework. The transition probabilities of the DTMC are then used to measure the ‘channel stability’, a metric that reflects the freshness of sensed channel interference. Next, out‐of‐band sensing‐based dynamic FH is analyzed following a continuous‐time Markov chain model, and a numerical procedure for determining the ‘optimal’ total sensing time that minimizes the probability of ‘black holes’ is provided. DTMC is appropriate for systems with continuously adjustable power levels; otherwise, continuous‐time Markov chain is the suitable model. We use simulations to study the effects of different system parameters on the performance of our proposed design. Copyright © 2014 John Wiley & Sons, Ltd.
Control Versus Data Flow in Parallel Database Machines

The execution of a query in a parallel database machine can be controlled in either a control flow way, or in a data flow way. In the former case a single system node controls the entire query execution. In the latter case the processes that execute the query, although possibly running on different nodes of the system, trigger each other. Lately, many database research projects focus on data flow control since it should enhance response times and throughput. The authors study control versus data flow with regard to controlling the execution of database queries. An analytical model is used to compare control and data flow in order to gain insights into the question which mechanism is better under which circumstances. Also, some systems using data flow techniques are described, and the authors investigate to which degree they are really data flow. The results show that for particular types of queries data flow is very attractive, since it reduces the number of control messages and balances these messages over the nodes. >
Mission-critical mobile broadband communications in open-pit mines

The need for continuous safety improvements and increased operational efficiency is driving the mining industry through a transition toward automated operations. From a communications perspective, this transition introduces a new set of high-bandwidth business-critical and mission- critical applications that need to be met by the wireless network. This article introduces fundamental concepts behind open-pit mining and discusses why this ever-changing environment and strict industrial reliability requirements pose unique challenges to traditional broadband network planning and optimization techniques. On the other hand, unlike unpredictable disaster scenarios, mining is a carefully planned activity. Taking advantage of this predictability element, we propose a framework that integrates mine and radio network planning so that continuous and automated adaptation of the radio network becomes possible. The potential benefits of this framework are evaluated by means of an illustrative example.
A novel approach to background subtraction in contrast-enhanced dual-energy digital mammography with commercially available mammography devices: Polychromaticity correction.

PURPOSE Contrast-enhanced digital mammography is an image subtraction technique that is able to improve the detectability of lesions in dense breasts. One of the main sources of error, when the technique is performed by means of commercial mammography devices, is represented by the intrinsic polychromaticity of the x-ray beams. The aim of the work is to propose an iterative procedure, which only assumes the knowledge of a small set of universal quantities, to take into account the polychromaticity and correct the subtraction results accordingly. METHODS In order to verify the procedure, it has been applied to an analytical simulation of a target containing a contrast medium and to actual radiographs of a breast phantom containing cavities filled with a solution of the same medium. RESULTS The reconstructed densities of contrast medium were compared, showing very good agreement between the theoretical predictions and the experimental results already after the first iteration. Furthermore, the convergence of the iterative procedure was studied, showing that only a small number of iterations is necessary to reach limiting values. CONCLUSIONS The proposed procedure represents an efficient solution to the polychromaticity issue, qualifying therefore as a viable alternative to inverse-map functions.
A computer-aided diagnosis system for breast DCE-MRI at high spatiotemporal resolution.

PURPOSE With novel MRI sequences, high spatiotemporal resolution has become available in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of the breast. Since benign structures in the breast can show enhancement similar to malignancies in DCE-MRI, characterization of detected lesions is an important problem. The purpose of this study is to develop a computer-aided diagnosis (CADx) system for characterization of breast lesions imaged with high spatiotemporal resolution DCE-MRI. METHODS The developed CADx system is composed of four main parts: semiautomated lesion segmentation, automated computation of morphological and dynamic features, aorta detection, and classification between benign and malignant categories. Lesion segmentation is performed by using a "multiseed smart opening" algorithm. Five morphological features were computed based on the segmentation of the lesion. For each voxel, contrast enhancement curve was fitted to an exponential model and dynamic features were computed based on this fitted curve. Average and standard deviations of the dynamic features were computed over the entire segmented area, in addition to the average value in an automatically selected smaller "most suspicious region. " To compute the dynamic features for an enhancement curve, information of aortic enhancement is also needed. To keep the system fully automated, the authors developed a component which automatically detects the aorta and computes the aortic enhancement time. The authors used random forests algorithm to classify benign lesions from malignant. The authors evaluated this system in a dataset of breast MRI scans of 325 patients with 223 malignant and 172 benign lesions and compared its performance to an existing approach. The authors also evaluated the classification performances for ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC), and invasive lobular carcinoma (ILC) lesions separately. The classification performances were measured by receiver operating characteristic (ROC) analysis in a leave-one-out cross validation scheme. RESULTS The area under the ROC curve (AUC) obtained by the proposed CADx system was 0.8543, which was significantly higher (p = 0.007) than the performance obtained by the previous CADx system (0.8172) on the same dataset. The AUC values for DCIS, IDC, and ILC lesions were 0.7924, 0.8688, and 0.8650, respectively. CONCLUSIONS The authors developed a CADx system for high spatiotemporal resolution DCE-MRI of the breast. This system outperforms a previously proposed system in classifying benign and malignant lesions, while it requires less user interactions.
Agile Radio Resource Management Techniques for 5G New Radio

The seven articles in this special section focus on agile radio resource management technologies for use in 5G mobile communications (5G). 5G networks will support a wide range of frequency bands, features, and use cases, with native support for efficient operation. 5G is considered as a significant disruptor to traditional mobile networks. Some of the main motivations behind the design, standardization, and deployment of the new generation of mobile networks include: significant increase of the supported data rates for enhanced mobile broadband, support for ultra-reliable and low-latency communications (URLLC), and support for massive machine type communications (mMTC). The combination of these 5G pillars can further enable new use cases, such as virtual or augmented reality (VR/AR), enabled by combining eMBB and URLLC.
Comparing the acceptance of information technology among public and private healthcare sector employees in Finland

The objective of this research is to examine information technology behaviour and beliefs among healthcare employees. The public healthcare sector is facing increased pressure to function more efficiently, and one solution to meet the new demands has been the introduction of information technology. However, the late and sparse adoption of new technology in the healthcare sector is both well known and documented. This study compares the IT acceptance dimension in the public and private healthcare sectors in Finland. Using data collected from a nationwide survey, descriptive statistics are provided to obtain an overview of the current state of IT acceptance. Comparisons provide evidence that the private healthcare sector is ahead in using IT and getting employees to accept it. Implications for technology management are discussed based on these findings.
4154 JIS 25/4 00.front.bcr

The aim of the paper is to illustrate the retrieval methods used to count the number of citations in the Institute for Scientific Information online databases (SciSearch and Social SciSearch) made available by the Deutsches Institut für Medizinische Dokumentation und Information host computer. Citation analysis is a bibliometric measure increasingly applied to evaluate the publication quality of individual scientists or research groups. Therefore, it is very important to know, and to use correctly, the search methods made available to retrieve the number of citations. Different search methods and their specific features and limits are discussed, and practical problems in working with the online citation indices are described, highlighting the pivotal role of information specialists to make accessible, and to better use, the database data and the retrieval techniques, thus providing vital information to institutions and research activity.
Endogenous Technical Progress in the Theory of Economic Growth

It is shown that substitutive work, which can be defined as work of production equipment (capital stock) replacing the efforts of workers in production processes, can be considered as a measure of technical progress. The methods of estimation of substitutive work are discussed. The theoretical results are illustrated on the data for the US. economy.
Redução da pressão arterial e do duplo produto de repouso após treinamento resistido em idosas hipertensas

BACKGROUND: Due to the existing controversies in literature about the potential benefits of resistance exercise training (RT) on arterial blood pressure (BP) at rest, and the lack of studies conducted with elderly hypertensive individuals, RT is seldom recommended as a non-pharmacological treatment for arterial hypertension. OBJECTIVE: To verify the effect of progressive RT on BP, HR, and RPP in elderly women with controlled hypertension. METHODS: 20 elderly women (66.8 ± 5.6 years of age), with a sedentary lifestyle, monitored with anti-hypertensive medication, participated in a 12-week RT program (resistance training group - RTG). Twenty-six elderly women (65.3 ± 3.4 years of age) with controlled hypertension did not engage in physical exercise during the study period, and composed the control group. RESULTS: After RT, there was a significant reduction in SBP, MBP, and DP values at rest. No significant drops in DBP and HR values at rest were observed after RT in both groups. The reduction in the RTG was 10.5 mmHg, 6.2 mmHg, and 2218.6 mmHg x bpm for SBP, MBP, and RPP, respectively. CONCLUSION: Progressive RT reduced SBP, MBP, and RPP values at rest of hypertensive elderly women who were on anti-hypertensive treatment.
Effects of Chronic Exposure to Crack Cocaine on the Respiratory Tract of Mice

Smoked cocaine (crack cocaine) causes several forms of injury to the respiratory tract, including asthma exacerbations, lung edema and hemorrhage, and nasal mucosal alterations. Few studies, however, have assessed respiratory tract pathology in habitual users of crack cocaine. Here, we describe the histological alterations in the respiratory tract of mice caused by chronic inhalation of crack cocaine. Twenty 2-month-old BALB/c mice were exposed to the smoke of 5 g crack cocaine in an inhalation chamber once a day for two months and compared to controls (n = 10). We then morphometrically analyzed nose and bronchiolar epithelial alterations, bronchiolar and alveolar macrophage cell density, alveolar hemosiderin content, and in addition determined the vasoconstriction index and the wall thickness of pulmonary arteries. The serum cocaine level was 212.5 ng/mL after a single inhalation. The mucus content of the nasal epithelium increased in crack-exposed animals, and the nasal and bronchial epithelium thickness decreased significantly. The alveolar hemosiderin content and the alveolar and bronchiolar macrophage cell density increased in animals exposed to crack. The vasoconstriction index increased in the pulmonary arteries of the exposed group. Chronic crack cocaine inhalation causes extensive histological changes along the entire respiratory tract.
Translocation Pathway of the Intratracheally Instilled C60 Fullerene from the Lung into the Blood Circulation in the Mouse: Possible Association of Diffusion and Caveolae-mediated Pinocytosis

Ultrafine particles are ubiquitous in ambient urban and indoor air from multiple sources and may contribute to adverse respiratory and cardiovascular diseases. Recently, it has been demonstrated that ultrafine particles (UFPs) are translocated from the lung into the systemic circulation. The exact pathway, however, for the translocation in the lung remains unclear. In this study, we examined the translocation pathway of intratracheally instilled C60 fullerene particles from the lung into the blood circulation in the mouse. Using light microscopy, aggregated particles of fullerene were observed in the capillary lumen in the lung and the pulmonary lymph nodes immediately after instillation. Electron microscopic analysis demonstrated an increased number of pinocytotic vesicles (caveolae) of various sizes in the type 1 alveolar epithelial cells (AEC) and endothelial cells; occasional caveolae containing some particulate substances were observed. In addition, particles of various sizes were observed throughout the structure of the air-blood barrier (ABB). These findings suggest that fullerene particles may pass the ABB by both diffusion and caveolae-mediated pinocytosis, resulting in immediate translocation into the systemic circulation.
Molecular Expression Analysis of β-Naphthoflavone-induced Hepatocellular Tumors in Rats

The present study was performed to characterize molecular expression levels of preneoplastic and neoplastic lesions induced by β-naphthoflavone (BNF), an aryl hydrocarbon receptor (AhR) agonist in rat hepatocarcinogenesis. Male F344 rats were initiated with an intraperitoneal injection of 200 mg/kg N-diethylnitrosamine, and two weeks later, they were fed a diet containing 0% or 1% BNF for twenty-eight weeks. All animals were subjected to a two-thirds partial hepatectomy at week 3 and sacrificed at week 30. Histopathologically, BNF increased the incidence and multiplicity of altered foci (1.7-fold and 3.3-fold) and hepatocellular adenomas (HCAs) (4.0-fold and 4.7-fold). Immunohistochemically, BNF increased the number of proliferating cell nuclear antigen (PCNA)-positive cells in altered foci (2.3-fold) and HCAs (6.7-fold) compared with the surrounding tissue and decreased the staining of cell cycle regulators (P21, C/EBPα). In addition, loss of reactivity for AhR-regulated (CYP1A1, CYP1B1) molecules and increased reactivity of Nrf-2-regulated (AKR7, GPX2) molecules were also observed in proliferative lesions. Furthermore, increased staining of histone deacetylase (HDAC1) in the nucleus was prominent in HCAs. The differential expression patterns were confirmed at mRNA levels by real-time reverse transcription-polymerase chain reaction (RT-PCR) analysis. These results suggest that enhanced cell proliferation and protection against oxidative stress play an important role in BNF-induced hepatocarcinogenesis in rats.
Design Considerations for Modeling Modes in Cyber–Physical Systems

Safety critical systems such as cruise control in automotive systems and variable rate bolus in medical device infusion pumps introduce complexity and reduce the flexibility of incremental code modifications. This paper proposes a generic pattern to structure the mode logic such that additions, modifications, and removal of behaviors could be done in a quick and localized fashion without losing model integrity. The authors illustrate the proposed pattern using the infusion pump as a case study and describe a design pattern for the mode logic of reactive systems that allows for flexible, understandable, and maintainable models.
Research Investigations into the Suitability of the LCx® Platform for Detection of Bloodborne Viruses

© 1998 S. Karger GmbH, Freiburg Fax (07 61) 4 52 07 14 www.karger. com Received: December 5, 1997 Accepted: January 26, 1998 Sharon Muldoon, Ph.D. Abbott Laboratories, Department 94K, Bldg. AP6C 100 Abbott Park Rd Abbott Park, IL 60064-3500 USA This article is also accessible online at: http://BioMedNet.com/karger Research Investigations into the Suitability of the LCx® Platform for Detection of Bloodborne Viruses K. Abravaya J. Cao R. Flanders J. Macioszek S. Muldoon J. Robinson
Control of nonlinear dynamical systems using neural networks. II. Observability, identification, and control

For pt. I see ibid., vol. 4 (1993). This paper considers the problems of regulation and tracking of a dynamical system when the state variables of the dynamical system are not accessible. The existence of the nonlinear maps describing the identifier and controller are first established and the implications for neural network realizations are described. Simulation results are included to complement the theoretical discussions.
Evidence of Oxidative Stress and Associated DNA Damage, Increased Proliferative Drive, and Altered Gene Expression in Rat Liver Produced by the Cholangiocarcinogenic Agent Furan

Furan is a potent cholangiocarcinogen in rat by an as yet undefined mechanism. The risk to man remains unclear. Using a time-course stop study design, we have investigated the potential of furan to induce oxidative stress and DNA damage associated with inflammatory and regenerative responses in rat liver. Furan was administered via oral gavage (30 mg/kg b.w. 5 daily doses per week), and livers were analyzed at time points between eight hr and three months. A one-month recovery group previously treated for three months was also included. There was a marked association between CYP2E1 expression and DNA oxidation (8-oxo-dG) in areas of centrilobular hepatocyte necrosis seen after a single dose. After one-month recovery from three-month treatment, 8-oxo-dG was still observed in areas of furan-induced cholangiofibrosis. Furan-induced changes in the expression of various genes associated with oxidative stress, DNA damage, and cell cycle control were identified during treatment and recovery. We propose that furan-induced cholangiocarcinomas emerge from areas of cholangiofibrosis as a result of a combination of chronic, persistent indirect damage to DNA through oxygen radicals coupled with persistent proliferative signals, including loss of connexin 32, that act to convert this DNA damage to fixed mutations.
Comparison of NTP Historical Control Tumor Incidence Rates in Female Harlan Sprague Dawley and Fischer 344/N Rats

The National Toxicology Program (NTP) has historically used Fischer 344/N (F344/N) rats for the majority of its bioassays. Recently the NTP began using the Harlan Sprague Dawley (SD) as the primary rat model for NTP studies. The NTP had previously used female SD rats in nine bioassays. This article compares historical control (HC) tumor incidence rates from these nine SD rat studies with HC tumor rates from matched NTP F344/N rat bioassays to identify similarities and differences. Matching on sex, laboratory, diet, and route led to nine comparable F344/N rat studies. Our analyses revealed statistically significant strain differences, with female SD rats having lower incidence rates for clitoral gland adenoma (0.2% vs. 5.8%) and mononuclear cell leukemia (0.9% vs. 16.7%) and higher incidence rates for mammary gland fibroadenoma (67.4% vs. 48.4%), mammary gland carcinoma (10.2% vs. 2.4%), and thyroid gland C cell adenoma (25.4% vs. 13.6%) relative to female F344/N rats. These represent five of the seven most common tumor types among female SD and F344/N rats in the NTP HC database. When vehicle was included as an additional matching criterion, the number of comparable F344/N rat studies dropped to four, but similar results were obtained.