Miracle-dz/UniFAR-FTUs huggingface dataset:
Apixaban for extended treatment of venous thromboembolism.

BACKGROUND Apixaban, an oral factor Xa inhibitor that can be administered in a simple, fixed-dose regimen, may be an option for the extended treatment of venous thromboembolism. METHODS In this randomized, double-blind study, we compared two doses of apixaban (2.5 mg and 5 mg, twice daily) with placebo in patients with venous thromboembolism who had completed 6 to 12 months of anticoagulation therapy and for whom there was clinical equipoise regarding the continuation or cessation of anticoagulation therapy. The study drugs were administered for 12 months. RESULTS A total of 2486 patients underwent randomization, of whom 2482 were included in the intention-to-treat analyses. Symptomatic recurrent venous thromboembolism or death from venous thromboembolism occurred in 73 of the 829 patients (8.8%) who were receiving placebo, as compared with 14 of the 840 patients (1.7%) who were receiving 2.5 mg of apixaban (a difference of 7.2 percentage points; 95% confidence interval [CI], 5.0 to 9.3) and 14 of the 813 patients (1.7%) who were receiving 5 mg of apixaban (a difference of 7.0 percentage points; 95% CI, 4.9 to 9.1) (P<0.001 for both comparisons). The rates of major bleeding were 0.5% in the placebo group, 0.2% in the 2.5-mg apixaban group, and 0.1% in the 5-mg apixaban group. The rates of clinically relevant nonmajor bleeding were 2.3% in the placebo group, 3.0% in the 2.5-mg apixaban group, and 4.2% in the 5-mg apixaban group. The rate of death from any cause was 1.7% in the placebo group, as compared with 0.8% in the 2.5-mg apixaban group and 0.5% in the 5-mg apixaban group. CONCLUSIONS Extended anticoagulation with apixaban at either a treatment dose (5 mg) or a thromboprophylactic dose (2.5 mg) reduced the risk of recurrent venous thromboembolism without increasing the rate of major bleeding. (Funded by Bristol-Myers Squibb and Pfizer; AMPLIFY-EXT ClinicalTrials.gov number, NCT00633893.).
Semantic Control Method of the Internet of Things Based on Linked Open Data

Variety of systems were developed based on the Internet of Things (IoT) concept including autonomous systems, which operate without human intervention. Development of such systems requires not only data from devices, but also interaction between these devices. It is necessary that one IoT-system could control other devices behavior. There are several problems related to that task including problem of incompatibility of different IoT APIs, requiring software support of each device in the system. This problem considerably restricts joint use of different devices from different IoT-systems. In this paper there is a method of control over the IoT-system is proposed. This method solves the problem described above. The method includes development of IoT API based on ontologies using Linked Open Data. The IoT interaction in the described method involves using control requests in the form of ontologies. The new ontologies synchronization mechanism is described which implemented links in Linked Open Data datasets allowing the dictionaries unification.
Active Disturbance Rejection Control of a SCARA Robot Arm

This paper is focused on a comparison between classic Feedback Linearization Control and a proposed Active Disturbance Rejection Control method. The proposed technique does not require a precise mathematical description of the system, since it is based on the online estimation and rejection of the unmodeled elements of the dynamics. Robustness of the closed-loop control system (against external perturbation and parameters uncertainty) is discussed here. A model of a SCARA robot manipulator is used in the conducted case study as an exemplary plant. Conclusions are supported with results obtained with numerical simulations.
Side translation by simultaneous shuffle turn for humanoid robots

This paper proposes a shuffle translating method combining shuffle turn repeatedly for a humanoid robot. Conventionally, the walking motion of a humanoid robot is performed by a repetition of stepping the feet. However, the motion is inefficient and has low stability. We have been studying the method of shuffle turning for humanoid robots, which can perform a stepless and stable turning in a narrow space. In this paper, we propose two shuffle translation methods by repeating shuffle turn. Experiments using a humanoid robot were conducted and the experimental results demonstrate the feasibility of these methods.
Test and evaluation system for multi-protocol sampled value protection schemes

Proposed transmission smart grids will use a digital platform for the automation of substations operating at voltage levels of 110 kV and above. The IEC 61850 series of standards, released in parts over the last ten years, provide a specification for substation communications networks and systems. These standards, along with IEEE Std 1588-2008 Precision Time Protocol version 2 (PTPv2) for precision timing, are recommended by the both IEC Smart Grid Strategy Group and the NIST Framework and Roadmap for Smart Grid Interoperability Standards for substation automation. IEC 61850-8-1 and IEC 61850-9-2 provide an inter-operable solution to support multi-vendor digital process bus solutions, allowing for the removal of potentially lethal voltages and damaging currents from substation control rooms, a reduction in the amount of cabling required in substations, and facilitates the adoption of non-conventional instrument transformers (NCITs). IEC 61850, PTPv2 and Ethernet are three complementary protocol families that together define the future of sampled value digital process connections for smart substation automation. This paper describes a specific test and evaluation system that uses real time simulation, protection relays, PTPv2 time clocks and artificial network impairment that is being used to investigate technical impediments to the adoption of SV process bus systems by transmission utilities. Knowing the limits of a digital process bus, especially when sampled values and NCITs are included, will enable utilities to make informed decisions regarding the adoption of this technology.
Pioneering STEM Education for Pre-Service Teachers

While there have been numerous initiatives to promote and recruit students into postsecondary studies in science, technology, engineering and mathematics (STEM) around the world, traditional programs of studies for both K to 12 school and teacher education still lack an integrative approach to these disciplines. Addressing this concern, the Werklund School of Education of the University of Calgary started to offer a course in STEM education for the undergraduate Bachelor of Education program. The purpose of this article is to document the first iterations of this course. We draw from narratives of four instructors, including the coordinator of the course, and administrators who were actively involved in creation and approval of the course. We describe the course and its connection to the philosophy of the program, examine the context in which this course was conceived—including both national and provincial policy—and address some challenges and possibilities experienced by administrators, instructors and students during the creation and implementation of the course.
Parallel particle filters for multiple target tracking

The Multiple Targets Tracking (MTT) problem is addressed in signal and image processing. When the state and measurement models are linear, we can find several algorithms that yield good performances in MTT problem, among them, the Multiple Hypotheses Tracker (MHT) and the Joint Probabilistic Data Association Filter (JPDAF). However, if the state and measurement models are nonlinear, these algorithms break down. In this paper we propose a method based on particle filters bank, where the objective is to make a contribution for estimating the trajectories of several targets using only bearings measurements. The main idea of this algorithm is to combine the Multiple Model approach (MM) with Sequential Monte Carlo methods (SMC). The result from this combination is a Nonlinear Multiple Model Particle Filters algorithm (NMMPF) able to estimate the trajectories of multiple targets.
Kinematics And Dynamics Of Flexible Space Robot Arms

Ab~tr~~t- The motion of free-floating flexible space robot manipulators is systematically studied. Both kinematic and dynamic models are presented. By analyzing the mapping relations among the velocity space of the joint, the flexible link, the end-effector and the satellite, the kinematic equations are formulated using 4 x 4 homogeneous transformation matrices. Based on the results, the Hamilton’s Principle and calculus of variations are used for deriving dynamic equations and a complete set of their boundary conditions.
Normal versus complete flow in dynamic texture recognition: a comparative study

We address the problem of dynamic texture (DT) classification using dierent techniques based on optic flow. The optic flow based approaches dominate among the currently available DT classification methods [4]. The optic flow features used by these methods often describe the local image distortion in terms of such quantities as curl or divergence. Both normal and complete flow have been considered, with the normal flow being used much more frequently. However, the precise meaning and the applicability of the normal and the complete flow features have never been analysed properly. In this paper, we provide a principled analysis of local image distortions and present the results of a DT classification study that compares the performances of the two types of flow with dierent features. The eect of the flow confidence measure introduced in [8] is also discussed.
Progress In Molecular And Subcellular Biology

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Triple Immunofluorescence Evidence for the Coexistence of Acetylcholine, Enkephalins and Calcitonin Gene‐related Peptide Within Efferent (Olivocochlear) Neurons of Rats and Guinea‐pigs

The efferent (olivocochlear) nerve supply to the cochlea is subdivided into a lateral and a medial innervation according to several criteria, e.g. locus of origin in the superior olivary complex and type of synaptic connections established in the organ of Corti. We have used a triple immunofluorescence colocalization approach to determine whether putative cholinergic neurons from the lateral innervation contain both metenkephalin and calcitonin gene‐related peptide (CGRP), and whether those from the medial innervation also contain CGRP. About 80% of the choline acetyltransferase (ChAT)‐like immunostained lateral efferent neurons within the lateral superior olive were CGRP‐ and metenkephalin‐like immunostained. In the organ of Corti, colocalization of the three antigens within the inner spiral bundle was also found. This bundle contains the lateral efferent synapses, with the dendrites of the primary auditory neurons innervating the sensory inner hair cells. Most of the medial efferent neurons in the ventral nucleus of the trapezoid body were only immunoreactive for ChAT. However, in the rostral part of the nucleus, a minority of ChAT‐like immunostained neurons were also CGRP‐like immunostained. None of the ChAT‐like immunostained medial efferent neurons presented metenkephalin‐like immunostaining. In agreement with these brainstem data, partial colocalization of the ChAT‐ and CGRP‐like immunostaining and a lack of metenkephalin immunoreactivity was noted below the sensory outer hair cells, which are the synaptic targets of medial efferent terminals in the organ of Corti. This distinction in the coexistence pattern of the two efferent innervations probably reflects distinct modes of action for acetylcholine in the cochlea. In one case, the effects of acetylcholine on the primary auditory neurons innervating the inner hair cells may require balanced modulation by metenkephalin and CGRP. In the other case, modulation of the effects of acetylcholine on the outer hair cells by neuropeptides would be less critical.
Universal multi-scale matching pursuits algorithm with reduced blocking effect

A method that reduces the blocking effect of the lossy compression of multi-dimensional data with a version of the UMMP (universal multi-scale matching pursuit) algorithm is presented. The method consists of a generalization of the previously presented UMMP which extends its use to bases with overlapping functions. We circumvent the difficult optimization problem posed by overlapping functions at the encoder by the use of two different bases, one for the encoding and another, with overlapping functions, for the decoding of the data.
CLEAR — A circuit level electric appliance radar for the electric cabinet

In this paper, we propose a cost-effective hardware design for acquiring high-resolution energy data from electricity mains to observe appliance switching transients. By utilizing these distinct appliance switching transients, we are interested to predict all appliances operating in a building and also estimate their power consumption. The proposed design fulfills the data acquisition requirements for effective appliance identification from aggregate load signals. Due to its unique and customizable features, the circuit level electric appliance radar (CLEAR) is capable of operating in multiple environments (residential, commercial, and industrial). CLEAR can simultaneously measure voltage and current data streams from a three-phase system at up to 250 kHz to accurately pinpoint individual appliance switching. The first prototype is installed in an office building to collect office level aggregate data. With this aggregate data, the main challenge lies in detecting and isolating similar appliance switching events from switched-mode power supplies (SMPS) utilized by most office appliances such as laptops, LCDs, and printers.
Knowledge of Hypertensive Patients With or Without HIV on Hypertension and Their Experience in Using Their Medicines in Dar es Salaam, Tanzania: The Role of the Pharmacist

Purpose: The study assessed the knowledge of both HIV and non-HIV hypertensive patients on hypertension and the role of pharmacists in their pharmaceutical care. Methods: The study was conducted at the hypertension and HIV clinics in government hospitals in Dar es Salaam, Tanzania. Patients were interviewed using a structured questionnaire and pharmacists were assessed using a self-administered questionnaire and by observation. Results: Few patients in both groups knew the names of antihypertensive medicines they were taking. Information on the use of antihypertensive and antiretroviral (ARV) medicines was mostly provided by doctors. Adverse drug reactions were significantly more when patient used both ARVs and antihypertensive medicines than when they used only antihypentsives. Only 20 % of hypertensive-HIV patients informed the pharmacist dispensing antihypertensive medicines that they were using ARVs, and only 19 % of the pharmacists knew the drug interactions between ARVs and antihypertensive medicines. During dispensing, about 2 % of the patients were asked about other medicines being used. Conclusion: There is a need to improve patients’ knowledge of hypertension. The pharmacists should also have up-to-date knowledge of hypertension-HIV co-morbidity. Proper coordination between HIV and hypertension clinics and the full integration of a pharmacist in the health care team can help to improve patient care. Keywords: Hypertension, HIV/AIDS, Antiretroviral medicines, Antihypertensive medicines, Adverse drug reaction, Dispensing, Knowledge
Neuropeptides and Their Functions in Hydra

In order to identify novel peptide signaling molecules involved in the regulation of developmental and physiological processes in the freshwater cnidarian, Hydra magnipapillata , we initiated a systematic peptide screening project, the Hydra Peptide Project. In the project, twelve neuropeptides were identified so far. The LWamide family is composed of seven members, which share a GLWamide motif at their C-termini. All the peptides have an ability to induce metamorphosis of Hydractinia serrata planula larvae into polyps. In Hydra , LWamides induce detachment of the bud from a parental polyp. A neuropeptide, Hym- 355, enhances neuronal differentiation by inducing the multipotent interstitial stem cells to enter the neuron differentiation pathway. A myoactive neutopeptide, Hym-176, specifically and reversibly induces contraction of the ectodermal muscle of the body column, in particularly in the peduncle region of epithelial Hydra that totally lack nerve cells. Two members of a novel neuropeptide family (FRamides) were contained in the same precursor. However, they have opposite myoactive functions in epithelial hydra. From these results, it seems fair to say reasonable to conclude that the so-called ‘primitive’ nervous system of Hydra is in reality more complex than generally believed.
Replisome Trafficking in Growing Vegetative Hyphae of Streptomyces coelicolor A3(2)

ABSTRACT We observed movies of replisome trafficking during Streptomyces coelicolor growth. A replisome(s) in the spore served as a replication center(s) until hyphae reached a certain length, when a tip-proximal replisome formed and moved at a fixed distance behind the tip at a speed equivalent to the extension rate of the tip.
Getting to the Real Story: What Vietnamese Business People Wish Foreigners Understood About Doing Business in Emerging and Transition Countries Like Vietnam – BEFORE They Start

Knowledge sharing typically examines organizational transfer of knowledge, often from headquarters to subsidiaries, from developed country sites to emerging country sites, or from host to local employees. Yes, recent research, such as Prahalad’s Bottom of the Pyramid, raises the question of reverse transfer of knowledge, or whether knowledge could and should be transferred from local sites to home country sites within an organization. As several emerging economies build their capabilities in knowledge, research and development, marketing, and the like, it only makes sense to consider what type of knowledge and how to transfer it in reverse or bi-directional manners. This paper takes one step back in the process. Rather than focusing on what knowledge transfer may make sense within an organization, we consider what types of knowledge are important for foreigners to know at the initial stages of engagement abroad as they consider whether to do business in an emerging country.
Converging coolness and investigating its relation to user experience

ABSTRACT Recently a number of studies appeared that operationalised coolness and explored its relation to digital products. Literature suggests that perceived coolness is another factor of user experience, and this adds to an existing explosion of dimensions related to aesthetics, hedonic quality, pragmatic quality, attractiveness, etc. A critical challenge highlighted in prior research is to study the relationships among those factors and so far, no studies have empirically examined the relationship between coolness and other established user experience factors. In this paper, we address this challenge by presenting two studies one that focuses on factors from two cool questionnaires, and one that compares them against existing User eXperience (UX) factors. Our findings show that factors from the two cool questionnaires converge and they also converge to existing, established UX factors. Thus, 11 distinct cool and UX factors converge into 5 for the case of mobile devices. Our findings are important for researchers, as we demonstrate through a validated model that coolness is part of UX research, as well as for practitioners, by developing a questionnaire that can reliably measure both perceived inner and outer coolness as well as the overall coolness judgement based on 5 factors and 21 items.
Impact of drying methods on physicochemical and sensory properties of apricot pestil

Fruit leathers, or traditionally named as pestil are intermediate moisture pectic gels, eaten as snack, manufactured by dehydration of fruit pulp into leathery sheets. The aim of the study was to evaluate physicochemical and sensory properties of apricot pestil dried with different methods. One group was sun dried, other group was dried in vacuum oven at 55°C and the last one was dried in microwave oven (90 W). Analysis of moisture, water soluble dry matter, pH, titratable acidity, total and reducing sugar, hydroxymethylfurfural, total phenolic compounds, antioxidant activity, minerals (K, Ca, Mg, Zn), color (L*, a*, b*) and sensory analysis were carried out. The moisture contents of apricot pestil samples were between 13.12±1.35 14.39±0.41 gm/100 gm. The HMF content of samples was affected by drying method. The HMF contents of microwave oven dried, vacuum oven dried and sundried pestil samples were 13.62±0.78, 19.39±0.26 and 45.64±1.29 mg/kg, respectively. Total phenolic compounds in samples were determined as between 110.03±0.72 121.24±6.19 mg GAE/100 gm. Retention of antioxidant activity of the sundried, microwave oven dried and vacuum oven dried samples was 59.80%, 39.23% and 19.15%, respectively. The mineral contents of pestil samples were higher because of increasing dry matter content. When comparing drying times, the shortest was observed in microwave oven drying followed by sun drying and vacuum oven drying. Drying methods considerably influenced the color changes of pestil samples. Chromatic parameters a*, b*, ∆Eab* and C*ab were found higher in microwave oven dried samples. Sensory evaluation analysis showed that all of the samples were acceptable by the panelists. The results of the analysis were important for selecting the quality criterion and for characterizing of this traditional product.