Miracle-dz/UniFAR-FTUs huggingface dataset:
A Resilience Model for Moderating Outcomes Related to Electronic Medical Record Downtime

The objective of this scoping review is to develop a model to understand the factors that influence clinical downtimes or clinical activities in a healthcare organization. To report on the results of searches preformed using seven bibliographic databases, using the logical search criteria of (downtime AND (EMR OR Electronic Medical Record OR EHR OR Electronic Health Record). After a title, abstract and full-text review 26 articles remained. The articles were coded and analyzed for themes. Downtime planning activities mitigate the effects of disasters on patient safety outcomes and clinical delays. A model was developed representing the relationships between disasters, the moderating variable of downtime planning activities and patient safety as well as clinical outcomes. Disasters can have significant impact on patients and health professionals. Downtime planning activities can be enacted when a disaster occurs to moderate the effects of the downtime on patients and clinical activities and can improve safety.
Enzyme Activity of Natural Products on Cytochrome P450

Drug-metabolizing enzymes, particularly the cytochrome P450 (CYP450) monooxygenases, play a pivotal role in pharmacokinetics. CYP450 enzymes can be affected by various xenobiotic substrates, which will eventually be responsible for most metabolism-based herb–herb or herb–drug interactions, usually involving competition with another drug for the same enzyme binding site. Compounds from herbal or natural products are involved in many scenarios in the context of such interactions. These interactions are decisive both in drug discovery regarding the synergistic effects, and drug application regarding unwanted side effects. Herein, this review was conducted as a comprehensive compilation of the effects of herbal ingredients on CYP450 enzymes. Nearly 500 publications reporting botanicals’ effects on CYP450s were collected and analyzed. The countries focusing on this topic were summarized, the identified herbal ingredients affecting enzyme activity of CYP450s, as well as methods identifying the inhibitory/inducing effects were reviewed. Inhibitory effects of botanicals on CYP450 enzymes may contribute to synergistic effects, such as herbal formulae/prescriptions, or lead to therapeutic failure, or even increase concentrations of conventional medicines causing serious adverse events. Conducting this review may help in metabolism-based drug combination discovery, and in the evaluation of the safety profile of natural products used therapeutically.
Contribution to the analysis and design of reflectarray antennas for reconfigurable beam applications at frequencies above 100 GHz using liquid crystal technology

The work presented in this thesis is focused on the development of electronically reconfigurable antennas that are able to provide competitive electrical performance to the increasingly common applications operating at frequencies above 60 GHz. Specifically, this thesis presents the study, design, and implementation of reflectarray antennas, which incorporate liquid crystal (LC) materials to scan or reconfigure the beam electronically. From a general point of view, a liquid crystal can be defined as a material whose dielectric permittivity is variable and can be controlled with an external excitation, which usually corresponds with a quasi-static electric field (AC). By changing the dielectric permittivity at each cell that makes up the reflectarray, the phase shift on the aperture is controlled, so that a prescribed radiation pattern can be configured. Liquid Crystal-based reflectarrays have been chosen for several reasons. The first has to do with the advantages provided by the reflectarray antenna with respect to other high gain antennas, such as reflectors or phased arrays. The RF feeding in reflectarrays is achieved by using a common primary source (as in reflectors). This arrangement and the large number of degrees of freedom provided by the cells that make up the reflectarray (as in arrays), allow these antennas to provide a similar or even better electrical performance than other low profile antennas (reflectors and arrays), but assuming a more reduced cost and compactness. The second reason is the flexibility of the liquid crystal to be confined in an arbitrary geometry due to its fluidity (property of liquids). Therefore, the liquid crystal is able to adapt to a planar geometry so that it is one or more of the typical layers of this configuration. This simplifies drastically both the structure and manufacture of this type of antenna, even when compared with reconfigurable reflectarrays based on other technologies, such as diodes MEMS, etc. Therefore, the cost of developing this type of antenna is very small, which means that electrically large reconfigurable reflectarrays could be manufactured assuming low cost and greater productions. A paradigmatic example of a similar structure is the liquid crystal panel, which has already been commercialized successfully.
Innovations in human resources management of higher education institutions: technostress factors

The study on technostress is very significant in today's knowledge-based society. Technostress, which has developed due to the information-technology explosion over the past decade, plays an increasingly critical role in people’s lives. The study shows that the flood of information and the increased use of more technological tools could cause frustration, anxiety, and fear. The timeliness of the topic lies in the fact that if society does not pay attention to this new kind of public disease now, it would have a negative impact on people's health, quality of life, and efficiency at the corporate level. The study's theoretical background was analyzed by reviewing the international scientific literature available on the subject of technostress. The research aims to explore the relationship between factors belonging to the group of technostress creators concerning Hungarian higher educational institutions. In the study, the authors set up a research model to explore the relationship between technostress creators, which was examined using a quantitative questionnaire query. The study covered 237 employees working in higher education in Hungary. The results were analyzed in the SPSS 22 statistical program. During the evaluation, linear regression analysis was used to explore these relationships. The results demonstrated that the five components of technostress are techno-overload, techno-invasion, techno-complexity, techno-insecurity, and techno-uncertainty. These frequently interact with each other in higher education. The results of the study point to the fact that the five components of technostress embodied in higher education institutions are interrelated, which, when appearing in the lives of university lecturers, contributes to the increase in the level of technostress. The research results could be useful for all higher education institutions in terms of what factors they should place great emphasis on to reduce or prevent technostress.
CE-SGD: Communication-Efficient Distributed Machine Learning

Training large-scale machine learning models usually demands a distributed approach to process the huge amount of training data efficiently. However, the high network communication cost introduced by parallel stochastic gradient descent (SGD) algorithms is a well-known bottleneck. To this end, we propose CE-SGD, a communication-efficient distributed machine learning algorithm that aggressively reduces the amount of gradient data exchanged among the training workers. CE-SGD belongs to the family of gradient sparsification schemes. CE-SGD adaptively adjusts the gradient sparsity according to the model's feedback. It also selectively transmits the gradients based on their degree of participation in the backpropagation. We mathematically prove the convergence of CE-SGD for both convex and non-convex cases and conduct a series of experiments on our CE-SGD implementation. Our experiments reveal that CE-SGD can achieve fast convergence, desirable gradient compression ratio, and high accuracy with low network bandwidth cost compared to state-of-the-art algorithms.
Evaluating Local Government Website Using a Synthetic Website Evaluation Model

One of the main strands in e-government research focuses on evaluating the government website. Previous studies have developed several models of government website evaluation. Unfortunately, that rich exploration of the government's website study seems to be ignored in the Indonesian e-government literature. Against that backdrop, this study formulated a synthetic model of government' website evaluation based on previous models developed by other scholars. It deployed them to assess ten local government websites (Municipality/Regency) in East Kalimantan. The model consists of two broad dimensions: technical and democratic deliberation. On the technical dimension, by using the SortSite 5.3. 5. software, it is found that the local governments' website performs relatively low on accessibility and errors on four metrics evaluated by the software. On the other side, on the democratic deliberation dimension, local government websites in East Kalimantan have performed relatively well in fulfilling the minimum of the democratic principle. We call it minimum because the websites have provided the user with basic information and several channels to interact with the officials.
Characteristics of Acoustic Emission Waveforms Induced by Hydraulic Fracturing of Coal under True Triaxial Stress in a Laboratory-Scale Experiment

Hydraulic fracturing (HF) is an effective technology to prevent and control coal dynamic disaster. The process of coal hydraulic fracturing (HF) induces a large number of microseismic/acoustic emission (MS/AE) waveforms. Understanding the characteristic of AE waveforms’ parameters is essential for evaluating the fracturing effect and optimizing the HF strategy in coal formation. In this study, laboratory hydraulic fracturing under true triaxial stress was performed on a cubic coal sample combined with AE monitoring. The injection pressure curve and temporal variation of AE waveforms’ parameters in different stages were analyzed in detail. The experimental results show that the characteristics of the AE waveforms’ parameters well reflect the HF growth behavior in coal. The majority of AE waveforms’ dominant frequency is distributed between 145 and 160 kHz during HF. The sharp decrease of the injection pressure curve and the sharp increase of the AE waveforms’ amplitude show that the fracture already runs through the coal sample during the initial fracture stage. The “trapezoidal” rise pattern of cumulative energy and most AE waveforms with low amplitude may indicate the stage of liquid storage space expansion. The largest proportion of AE waveforms’ energy and higher overall level of AE waveforms’ amplitude occur during the secondary fracture stage, which indicates the most severe degree of coal fracture and complex activity of internal fracture. The phenomenon shows the difference in fracture mechanism between the initial and secondary fracture stage. We propose a window-number index of AE waveforms for better response to hydraulic fracture, which can improve the accuracy of the HF process division.
The Potential Therapeutic Effect of Orexin-Treated versus Orexin-Untreated Adipose Tissue-Derived Mesenchymal Stem Cell Therapy on Insulin Resistance in Type 2 Diabetic Rats

Type 2 diabetes mellitus is a chronic metabolic disease characterized by resistance to peripheral insulin actions. Mesenchymal stem cells have been studied for years in T2DM therapy, including adipose tissue-derived mesenchymal stem cells (AD-MSCs). Orexin neuropeptides (A and B) are well-known regulators of appetite and physical activity. The aim of this work was to elucidate the possible therapeutic effect of AD-MSC preconditioning with orexin A (OXA) on insulin resistance in rats. Twenty-eight adult male albino rats were divided into 4 equal groups: a normal control group and 3 diabetic groups (a control T2DM group, diabetic rats treated by an AD-MSCs group, and diabetic rats treated by AD-MSCs preconditioned with OXA). We noticed that the treated groups showed a significant alleviation of insulin resistance parameters as shown in lowering the serum levels of glucose, insulin, total cholesterol, inflammatory markers, and HOMA-IR as compared to the control diabetic group with more significant reduction observed in the OXA-pretreated AD-MSCs-administrated group. More improvement was also noted in the glucose uptake and GLUT-4 gene expression in the skeletal muscle and adipose tissue in the OXA-pretreated AD-MSCs-administrated group compared to the untreated diabetic group. Conclusion. Preconditioning of AD-MSCs with OXA can significantly increase their potential to reduce the insulin resistance in the rat model of T2DM.
Perioperative Pain Management Practices Vary Across Time and Setting for Pediatric ACL Reconstruction: Trends From a National Database in the United States

Background: Surgical and anesthetic techniques have enabled a shift to the ambulatory setting for the majority of patients with anterior cruciate ligament (ACL) tears. While this change likely reflects improvements in acute pain management, little is known about national trends in pediatric perioperative pain management after ACL reconstruction (ACLR). Purpose: To describe recent trends in the United States in perioperative pain management for pediatric ACLR. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Pediatric patients (age, ≤18 years) who underwent ACLR with peripheral nerve blocks between January 2008 and December 2017 were identified in the Pediatric Health Information System database. We modeled the use of oral and intravenous analgesic medications over time using Bayesian logistic mixed models. Models were adjusted for patient age, sex, race, primary payer, and treatment setting (ambulatory, observation, or inpatient). Results: The study criteria produced a sample of 18,605 patients. Older children were more likely to receive intravenous acetaminophen, intravenous ketorolac, and oral and intravenous opioids. Younger children were more likely to receive ibuprofen. In our adjusted logistic model, treatment setting was found to be an independent predictor of the utilization of all medications. We found an increase in the overall utilization of oral acetaminophen (adjusted odds ratio [adj OR], 1.14 [95% CI, 1.04-1.23]), intravenous acetaminophen (adj OR, 1.42 [95% CI, 1.22-1.65]), and oral opioids (adj OR, 1.16 [95% CI, 1.06-1.28]) over the study period at a typical hospital. We found significant heterogeneity in medication use across hospitals, with the most heterogeneity in intravenous acetaminophen. Other studied descriptive variables did not appear to predict practices. Conclusion: After adjusting for patient characteristics and treatment settings, pain management strategies varied among hospitals and over time. Patient age and treatment setting predicted practices. Regional anesthesia, opioid medications, and intravenous ketorolac remained the mainstays of treatment, while intravenous acetaminophen emerged in use over the course of the study period. The variability in the pain management of pediatric patients undergoing ACLR suggests that further study is necessary to establish the most effective means of perioperative pain management in these patients.
Impact of Drying Methods on the Quality of Bioactive Components in Tree Tomato (Cyphomandra betacae)

Tamarillo (Cyphomandra betacea) is a tree native to Peru and is cultivated in few areas of Western and Eastern Ghats in India. It has high nutritive and therapeutic value due to the abundance of health promoting substances. Owing to its high nutritive profile, a study was conducted to examine the nutritional composition of fresh fruits and dried fruit powder. Fresh Tamarillo was dried under different methods of drying (sun drying, cabinet/tray drying and freeze drying). The dried samples were made into powder and used for comparative analysis of various bioactive constituents and antioxidants (antioxidant activity, total phenols, carotene, vitamin C, colour value, elemental analysis). From the results it was observed that the samples dried under freeze dried condition exhibited better antioxidant activity (13.82 mg/g), carotene (15.97 mg/100 g), vitamin C content (217.1 mg/100 g) than that of the samples dried under sun drying and cabinet tray drying. This might be due to long exposure time and leaching effect of the tamarillo samples to air. Among the three drying methods, sun drying resulted in significant micronutrient loss and exhibited low antioxidant activity due to the use of uncontrolled temperature during drying process. This underutilized fruit is consumed in the fresh form as it is a seasonal fruit. Converting the seasonal fruit into dried or powder form will help in development of nutria-rich food products. HIGHLIGHTS Tamarillo is an underutilized fruit that possesses higher nutritional and therapeutic values. The extract of the fruits also contains a wide range of antioxidant activities Study on the nutritional profile and antioxidant activity of tamarillo was conducted with the samples dried under different drying conditions (sun drying, cabinet tray drying and freeze drying) The samples dried under freeze dried condition exhibited better antioxidant activity The tamarillo fruits could be a better source to develop antioxidant rich value-added products, nutraceuticals and bio colorant GRAPHICAL ABSTRACT
TOWARDS GLOBAL RIVER DISCHARGE ASSESSMENT USING A DISTRIBUTED HYDROLOGICAL MODEL AND GLOBAL DATA SETS

To improve global water resource assessment, quantification of the global river discharge while considering the effect of slopes is required. Rainfall patterns need to be transformed into discharge by hydrological models like a distributed hydrological model (DHM). This model is expected to represent the spatial variation in aspects of digital global mapping such as land use, land cover, vegetation and elevation. Particularly, a digital elevation model (DEM) is crucial for tracking the flow direction and defining the river network in a basin. In this study, the performance of a 1-km resolution DHM is compared with that of a 90-m resolution DHM in simulating the discharge of the Meghna River in Bangladesh. The input rainfall was obtained from the Tropical Rainfall Measuring Mission (TRMM). The TRMM raw data was improved using available rain gauges over Bangladesh employing correcting factors. These correction factors were then also extended over India where rain gauge data was not available. In summary, the simulation of river discharge using the 1-km resolution model gave reasonable results even though the condition of the slope was limited. Therefore, the procedure here shows the feasibility of modeling global river discharge using global mapping data set. In future development, after setting thresholds at different control points, the potential flood damage to population centres can be evaluated for sound decision making.
Syntax-based guidance for autonomous aggressive aerobatics in urban environments

for Autonomous Aggressive Aerobatics in Urban Environments by Rodin Lyasoff S.B. , Massachusetts Institute of Technology (2002) Submitted to the Department of Aeronautical Engineering in partial fulfillment of the requirements for the degree of Master of Science at the MASSACHUSETTS INSTITUTE OF TECHNOLOGY September 2004 ( Rodin Lyasoff, MMIV. All rights reserved. The author hereby grants to MIT permission to reproduce and distribute publicly paper and electronic copies of this thesis document in whole or in part.
Mate-value and relationship satisfaction: The moderating roles of mate retention behaviors

Previous research indicates that mate retention strategies are associated with mate value and affect relationship satisfaction. The current research aimed to replicate previous findings in a non-WEIRD society (Iran) and to extend this research by investigating the moderating roles of individual and coalitional mate retention. Participants (n = 754; 416 women) in a committed, heterosexual relationship from two independent samples reported (1) their relationship satisfaction, (2) their partner’s mate value, (3) the frequency of performing individual mate retention, and (4) the frequency of requesting coalitional mate retention. Results indicated that there were positive associations between mate value, individual and coalitional Benefit-Provisioning mate retention behaviors, and relationship satisfaction. We found negative associations between individual and coalitional Cost-Inflicting mate retention behaviors and relationship satisfaction. We found that mate retention moderated the relationship between mate value and relationship satisfaction. Limitations of the current study are noted, and future directions are discussed.
Long Term Follow-up of Composite Flaps for Single-stage Reconstruction of Concomitant Tendon and Soft Tissue Defects

Background: Tendon rupture in the setting of significant soft tissue loss poses a challenging reconstructive situation, which requires (1) recreating a stable gait cycle, (2) reducing shear forces and re-rupture risk, and (3) providing adequate soft tissue coverage. In this study, we outline our experience with composite flaps in single-step reconstruction of various lower extremity tendinous injuries with soft tissue loss. Methods: A retrospective review of all patients requiring free tissue transfer at our tertiary wound care center between 2011 and 2020 was performed. Patients undergoing single-stage free tissue transfer for both soft tissue coverage and tendon reconstruction were selected. Variables of interest included demographics, comorbid conditions, baseline functionality, reconstructive details, and wound characteristics. Outcomes of interest were flap success, return to ambulation, time to ambulation, and postoperative complications. Results: Nineteen patients were included in this study. Patients were on average 48.0 years old (SD 16.5), with a median Charlson Comorbidity Index of 1.00 (IQR: 0.0–2.5). Defects were most often on the ankle (n = 1 3, 68.4%), with extension to the foot or leg in six of these cases. Median wound size was 68.0 cm2 (IQR: 48.0–120.0). The most common tendon requiring reconstruction was the Achilles (n = 13, 68.4%). An anterolateral thigh flap with attached fascia lata extension rolled into a neotendon was used in all 19 cases. At baseline, all patients were ambulatory. Only one patient (5.3%) required return to the operating room for suspected vascular compromise. At a median of 14.4 months (IQR: 8.5–40.5), all 19 patients were ambulatory. Conclusions: Simultaneous reconstruction of tendinous injuries and soft tissue defects can be readily achieved via composite free flaps. Although other methods of reconstruction can be considered for smaller soft tissue and tendon loss, this approach has significant utility for patients with large defects and yields robust return to preinjury functionality.