Miracle-dz/UniFAR-FTUs huggingface dataset:
Intrinsic network changes associated with cognitive impairment in patients with hearing loss and tinnitus: a resting-state functional magnetic resonance imaging study

Background Hearing loss and tinnitus often occur concurrently and play a vital role in the development and progression of cognitive impairment (CI). However, the exact mechanism remains unclear. This study aimed to investigate the changes in intrinsic brain connectivity in patients with hearing loss and tinnitus accompanied by CI. Methods A total of 24 hearing loss and tinnitus patients with CI, 23 hearing loss and tinnitus patients with cognitive normality (CN), and 20 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rs-fMRI). Resting-state networks (RSNs) were identified and intrinsic functional connectivity (FC) values were measured using independent component analysis (ICA). FC values within the RSNs were measured and correlations between altered RSNs and clinical characteristics were evaluated using Pearson correlation analysis. Results No significant difference was found in the disease duration or Tinnitus Handicap Inventory (THI) scores between the CI and CN groups. Eleven RSNs differed significantly among the 3 groups. Compared with the CN group, the CI group exhibited higher FC in the right supramarginal and left middle temporal gyri within the auditory network (AN), the left inferior parietal, but supramarginal and angular gyrus (IPL) gyrus within the right frontoparietal network (RFPN), the right middle occipital gyrus (R_MOG) and left superior frontal gyrus (L_SFG) within the dorsal attention network (DAN), the right middle frontal gyrus (R_MFG) within the executive control network (ECN), the right cuneus (R_cuneus) within the visual network (VN), and the left inferior frontal gyrus within the salience network (SAN), as well as lower FC in the right superior temporal gyrus (R_STG) within the AN and the left FPN (LFPN) and the right superior frontal gyrus (R_SFG) within the LFPN. Montreal Cognitive Assessment (MoCA) scores were negatively correlated with the FC values of the R_MFG and positively correlated with the FC values of the R_STG and R_SFG. Conclusions Aberrant intrinsic FC was observed in the R_MFG within the ECN, the R_STG within the AN, and the R_SFG within the LFPN in hearing loss and tinnitus patients, which may be a biomarker for the severity of CI in hearing loss and tinnitus patients.
Synthesis, Self-Assembly, and Cell Responses of Aromatic IKVAV Peptide Amphiphiles

Synthetic bioactive aromatic peptide amphiphiles have been recognized as key elements of emerging biomedical strategies due to their biocompatibility, design flexibility, and functionality. Inspired by natural proteins, we synthesized two supramolecular materials of phenyl-capped Ile-Lys-Val-Ala-Val (Ben-IKVAV) and perfluorophenyl-capped Ile-Lys-Val-Ala-Val (PFB-IKVAV). We employed UV-vis absorption, fluorescence, circular dichroism, and Fourier-transform infrared spectroscopy to examine the driving force in the self-assembly of the newly discovered materials. It was found that both compounds exhibited ordered π-π interactions and secondary structures, especially PFB-IKVAV. The cytotoxicity of human mesenchymal stem cells (hMSCs) and cell differentiation studies was also performed. In addition, the immunofluorescent staining for neuronal-specific markers of MAP2 was 4.6 times (neural induction medium in the presence of PFB-IKVAV) that of the neural induction medium (control) on day 7. From analyzing the expression of neuronal-specific markers in hMSCs, it can be concluded that PFB-IKVAV may be a potential supramolecular biomaterial for biomedical applications.
Combination of the Modified Loop Technique and De Vega Annuloplasty in Dogs with Mitral Regurgitation

Simple Summary Dogs, like humans, may develop valvular disease, which is particularly common in older, small-sized dogs and is one of the most common causes of canine death. Canine valvular disease generally has a good prognosis. However, approximately 30% of dogs develop congestive heart failure, particularly when the mitral valve is affected, and most dogs with severe congestive heart failure die within a year of pulmonary edema. Although cardiac surgery with extracorporeal circulation can be performed in dogs and can significantly prolong survival, the dogs’ small size is challenging from a surgical perspective, and the success rate depends on the surgeon’s skill. Mitral valve repair in dogs involves suturing cardiac tendons using polytetrafluoroethylene sutures, which are slippery and difficult to ligate at the targeted length. Moreover, the appropriate length of the artificial tendon in dogs has not been determined. The mitral annulus surrounding the mitral valve also needs to be stitched down, but the amount that should be stitched down in dogs is not known because prosthetic valve rings were not manufactured for dogs. Due to the lack of reports detailing surgical procedures in dogs, we describe in detail a surgical technique for canine mitral valve repair. Abstract Background: Detailed surgical techniques for treating canine mitral regurgitation have not been previously reported. Method: This case series included six consecutive client-owned dogs with mitral regurgitation. All dogs underwent a combined protocol, including the modified loop technique and De Vega annuloplasty (MODEL surgery), in 2021. Artificial loops covering 80% of the length of the strut chordae tendineae were used for chordal replacement. Mitral annuloplasty was subjectively performed, targeting the circumference of the septal leaflet. Results: The breeds were Chihuahua-mixed breed, Spitz, Pomeranian, Cavalier King Charles Spaniel, and Chihuahua, with average ages and weights of 11.4 ± 2.3 years and 5.49 ± 2.98 kg, respectively. The aortic cross-clamp, pumping, and surgery times were 64.0 ± 7.5 min, 168.5 ± 39.1 min, and 321.0 ± 53.1 min, respectively. After MODEL surgery, left atrial-to-aortic ratios significantly decreased from 2.20 ± 0.18 to 1.26 ± 0.22 (p < 0.01), and left ventricular end-diastolic internal diameter normalized to body weight significantly decreased from 2.03 ± 0.26 to 1.48 ± 0.20 (p < 0.01). In all cases, the clinical signs disappeared or improved significantly. Conclusions: MODEL surgery increased mitral valve coaptation, normalized heart sizes, and significantly improved clinical signs in dogs with mitral regurgitation.
Hemostasis Disturbances in Continuous-Flow Left Ventricular Assist Device (CF-LVAD) Patients—Rationale and Study Design

Left ventricular assist devices are a treatment option for end-stage heart failure patients. Despite advancing technologies, bleeding and thromboembolic events strongly decrease the survival and the quality of life of these patients. Little is known about prognostic factors determining these adverse events in this group of patients. Therefore, we plan to investigate 90 consecutive left ventricular assist device (LVAD) patients and study in vitro fibrin clot properties (clot lysis time, clot permeability, fibrin ultrastructure using a scanning electron microscope) and the calibrated automated thrombogram in addition to the von Willebrand factor antigen, fibrinogen, D-dimer, prothrombin time/international normalized ratio (PT/INR), and activated partial thromboplastin time (APTT) to identify prognostic factors of adverse outcomes during the course of therapy. We plan to assess the hemostasis system at four different time points, i.e., before LVAD implantation, 3–4 months after LVAD implantation, 6–12 months after LVAD implantation, and at the end of the study (at 5 years or at the time of the adverse event). Adverse outcomes were defined as bleeding events (bleeding in general or in the following subtypes: severe bleeding, fatal bleeding, gastrointestinal bleeding, intracranial bleeding), thromboembolic events (stroke or transient ischemic attack, pump thrombosis, including thrombosis within the pump or its inflow or outflow conduits, arterial peripheral thromboembolism), and death.
KIC 5768203: A δ Sct Pulsator Modulated by Rotation and Spots

We perform a detailed analysis of the Kepler target KIC 5768203 based on the Kepler and Transiting Exoplanet Survey Satellite (TESS) data. Three independent frequencies are detected by Fourier analysis of the Kepler long-cadence data: two pulsation frequencies f P0 = 7.807874(2) day−1 and f P1 = 9.970035(6) day−1, which have amplitudes below 1.4 mmag in the Kepler band, and one modulation frequency f rot = 0.45813(1) day−1. Based on a period ratio of 0.7803, f P0 and f P1 are supposed to be radial frequencies. However, further confirmation is needed. Based on the triplets and phase variations of the two pulsation frequencies, the star is possibly a δ Sct pulsator in a binary system. The modulation frequency f rot and its four harmonics could be attributed to the stellar rotation and surface spots. With the rotation frequency f rot, the rotation velocity of the star is estimated to be 75(3) km s−1. By analyzing the phase diagram without pulsations, it is inferred that there are starspots (or clusters of starspots) of large area on the surface of KIC 5768203. These starspots are slowly evolving in position and brightness over the course of the Kepler long-cadence observations. The finding of the rotation frequency in the TESS data implies the long-term presence of starspots on the surface of KIC 5768203.
Choline Chloride/Urea Deep Eutectic Solvents: A Promising Reaction Medium for the Synthesis of Bio-Based Poly(hydroxyurethane)s

The development of more sustainable and eco-friendly polymers has attracted much attention from researchers over the past decades. Among the different strategies that can be implemented towards this goal, the substitution of the toxic reagents/monomers often used in polyurethane chemistry has stimulated much innovation leading to the development of the hydroxylated version of PURs, namely, the poly(hydroxyurethane)s (PHURs). However, some PHURs remain far from being sustainable as their synthesis may involve monomers and/or solvents displaying poor environmental impacts. Herein, we report on the use of more sustainable conditions to synthesize the biobased polycarbonates involved in the aminolysis reaction. In addition, we demonstrate that the use of renewable deep eutectic solvents (DESs) can act both as excellent solvents and organocatalysts to promote the aminolysis reaction.
Mechanism of Negative Emotions of the Elderly in Normalization Period of COVID-19: A Mediated Mediation Model

To explore the mechanism of negative emotions of the elderly in normalization period of COVID-19. The self-rating Depression Anxiety Stress Scale, epidemic attention scale, subjective economic status scale and physical health perception scale were used to investigate 318 elderly people in 2021. There were significant differences in negative emotions among the elderly in Henan in China with different gender, education background, medical insurance and whether they contacted suspected cases (all P < 0.05), but there was no significant difference on religious belief (P > 0.05); Attention to epidemic information was positively correlated with negative emotion (r = 0.492, P < 0.01), and negatively correlated with subjective economic status (r = −0.138, P < 0.05); Negative emotions were negatively correlated with subjective economic status (r = −0.455, P < 0.01) and health perception (r = −0.277, P < 0.01); health perception was no significant correlation with epidemic attention(r = −0.047, P > 0.05) and subjective economic status (r = −0.033, P > 0.05). Bootstrap test found that epidemic attention can significantly predict negative emotion of the elderly (β = 0.492, P < 0.001), subjective economic status played a partial mediating role between epidemic attention and negative emotions (β = 0.438, −0.395, P < 0.001), and health perception moderated the first half of the mediating path (β = 0.403, P < 0.001, 95% CI = [0.286~0.521]). Epidemic attention has a significant positive impact on the negative emotions of the elderly in Henan during normalization period of COVID-19, and it has effect indirectly through subjective economic status; health perception plays a moderator role in the impact of epidemic attention on subjective economic status.
Two loop integrals and QCD scattering

We present the techniques for the calculation of one- and two-loop integrals contributing to the virtual corrections to 2→2 scattering of massless particles. First, tensor integrals are related to scalar integrals with extra powers of propagators and higher dimension using the Schwinger representation. Integration By Parts and Lorentz Invariance recurrence relations reduce the number of independent scalar integrals to a set of master integrals for which their expansion in є = 2 — D/2 is calculated using a combination of Feynman parameters, the Negative Dimension Integration Method, the Differential Equations Method, and Mellin-Barnes integral representations. The two-loop matrix-elements for light-quark scattering are calculated in Conventional Dimensional Regularisation by direct evaluation of the Feynman diagrams. The ultraviolet divergences are removed by renormalising with the MS scheme. Finally, the infrared singular behavior is shown to be in agreement with the one anticipated by the application of Catani's formalism for the infrared divergences of generic QCD two-loop amplitudes.
Ovarian Adnexal Reporting Data System (O-RADS) for Classifying Adnexal Masses: A Systematic Review and Meta-Analysis

Simple Summary We performed a systematic review and meta-analysis aiming to assess the diagnostic performance of the Ovarian Adnexal Report Data System (O-RADS) using transvaginal ultrasound for classifying adnexal masses. Data from 11 studies comprising 4634 masses showed that the pooled estimated sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio of O-RADS system for classifying adnexal masses were 97% (95% confidence interval (CI) = 94%–98%), 77% (95% CI = 68%–84%), 4.2 (95% CI= 2.9–6.0), 0.04 (95% CI = 0.03–0.07), and 96 (95% CI = 50–185), respectively. We concluded that the O-RADS system has good sensitivity and moderate specificity for classifying adnexal masses. Abstract In this systematic review and meta-analysis, we aimed to assess the pooled diagnostic performance of the so-called Ovarian Adnexal Report Data System (O-RADS) for classifying adnexal masses using transvaginal ultrasound, a classification system that was introduced in 2020. We performed a search for studies reporting the use of the O-RADS system for classifying adnexal masses from January 2020 to April 2022 in several databases (Medline (PubMed), Google Scholar, Scopus, Cochrane, and Web of Science). We selected prospective and retrospective cohort studies using the O-RADS system for classifying adnexal masses with histologic diagnosis or conservative management demonstrating spontaneous resolution or persistence in cases of benign appearing masses after follow-up scan as the reference standard. We excluded studies not related to the topic under review, studies not addressing O-RADS classification, studies addressing MRI O-RADS classification, letters to the editor, commentaries, narrative reviews, consensus documents, and studies where data were not available for constructing a 2 × 2 table. The pooled sensitivity, specificity, positive and negative likelihood ratios, and diagnostic odds ratio (DOR) were calculated. The quality of the studies was evaluated using QUADAS-2. A total of 502 citations were identified. Ultimately, 11 studies comprising 4634 masses were included. The mean prevalence of ovarian malignancy was 32%. The risk of bias was high in eight studies for the “patient selection” domain. The risk of bias was low for the “index test” and “reference test” domains for all studies. Overall, the pooled estimated sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and DOR of the O-RADS system for classifying adnexal masses were 97% (95% confidence interval (CI) = 94%–98%), 77% (95% CI = 68%–84%), 4.2 (95% CI = 2.9–6.0), 0.04 (95% CI = 0.03–0.07), and 96 (95% CI = 50–185), respectively. Heterogeneity was moderate for sensitivity and high for specificity. In conclusion, the O-RADS system has good sensitivity and moderate specificity for classifying adnexal masses.
Multispecies and high-spatiotemporal-resolution database of vehicular emissions in Brazil

Abstract. In this article, we present the BRAzilian Vehicular Emissions inventory Software (BRAVES) database, a multispecies and high-spatiotemporal-resolution database of vehicular emissions in Brazil. We provide this database using spatial disaggregation based on road density, temporal disaggregation using vehicular flow profiles, and chemical speciation based on local studies and the SPECIATE 5.1 database from the United States Environmental Protection Agency (US EPA). Our BRAVES database provides hourly and annual emissions of 41 gaseous and particle pollutants, where users can define the spatial resolution, which ranges from a coarse to a very refined scale. Spatial correlation analysis reveals that the BRAVES database reaches better performance than the vehicular emissions inventory from the Emissions Database for Global Atmospheric Research (EDGAR). A comparison with the Modern-Era Retrospective analysis for Research and Applications, Version 2 (MERRA-2) surface concentration confirms the consistency and reliability of the BRAVES database in representing the spatial pattern of vehicular emissions. Compared to EDGAR, the BRAVES database brings more spatial, temporal, and chemical details. These additional features are crucial to understanding important atmospheric chemistry processes in Brazil. All codes and inputs are freely available, and the outputs are compatible with the input requirements of sophisticated chemical transport models. We envision that our database will enable the scientific and environmental community to gain new insights into vehicular emissions and their effects in Brazil, where emissions inventories are scarce and urgently needed. The BRAVES database is freely available at https://doi.org/10.5281/zenodo.6588692 (Hoinaski et al., 2022).
Food insecurity as experienced by New Zealand women and their children

ABSTRACT Food insecurity, defined as uncertainty in reliably accessing adequate quantities of nutritious food, is an issue for many families and children, including in New Zealand. Drawing on the experiences of mothers, this study explored the nature, causes and impact of food insecurity for their families. Semi-structured face-to-face interviews conducted with six female sole-parents were complemented with food insecurity data from the NZ Health Survey and Youth2000 surveys. Interviews were audio-recorded, transcribed and emergent themes analysed. The major driver of food insecurity was low income relative to essential household outgoings. Coping strategies employed invariably involved reducing the quantity and quality of food consumed. Negative impacts of food insecurity included significant stress, neglect of personal needs and missing meals in favour of children. Concerns expressed for children included reduced provision of nutritious food and constrained social and recreational opportunities. Participants described the daily struggle of feeding their household despite personal sacrifices, a range of coping strategies and community support. Quantitative data showed persistent high prevalence of household food insecurity with inequity by ethnicity and disability status. Findings highlight food insecurity as an ongoing public health issue for which urgent action is required to reduce its damaging impacts on families and children.
Removal of Ni(II) Ions by Poly(Vinyl Alcohol)/Al2O3 Nanocomposite Film via Laser Ablation in Liquid

Al2O3-poly(vinyl alcohol) nanocomposite (Al2O3-PVA nanocomposite) was generated in a single step using an eco-friendly method based on the pulsed laser ablation approach immersed in PVA solution to be applicable for the removal of Ni(II) from aqueous solution, followed by making a physicochemical characterization by SEM, XRD, FT-IR, and EDX. After that, the effect of adsorption parameters, such as pH, contact time, initial concentration of Ni(II), and medium temperature, were investigated for removal Ni(II) ions. The results showed that the adsorption was increased when pH was 5.3, and the process was initially relatively quick, with maximum adsorption detected within 90 min of contact time with the endothermic sorption process. Moreover, the pseudo-second-order rate kinetics (k2 = 9.9 × 10−4 g mg−1 min−1) exhibited greater agreement than that of the pseudo-first-order. For that, the Ni(II) was effectively collected by Al2O3-PVA nanocomposite prepared by an eco-friendly and simple method for the production of clean water to protect public health.
Understanding Students’ Acceptance and Usage Behaviors of Online Learning in Mandatory Contexts: A Three-Wave Longitudinal Study during the COVID-19 Pandemic

Online learning has been mandatorily adopted in many countries due to the closure of educational institutions caused by the COVID-19 pandemic. However, antecedents of the acceptance and continuance of online learning in such a situation and their changing role over time have not been well understood. This study proposed and empirically tested a longitudinal acceptance model of online learning by integrating the technology acceptance model (TAM) with the task–technology fit (TTF). Data were collected using a three-wave longitudinal survey from 251 Chinese college students after the outbreak of the COVID-19 pandemic. The results showed that most hypothesized relationships in the proposed model were supported and remained across the three-time stages, while the effects of perceived ease of use on perceived usefulness and behavioral intention changed over time. In addition, students’ perceptions at previous stages had little impact on perceptions at subsequent stages, except for perceived usefulness and behavioral intention. Our study demonstrates that the integrated model of TAM and TTF could be an effective tool to understand students’ acceptance of online learning across different time stages in a mandatory setting and that longitudinal design could be applicable to examine the changing mechanism of the acceptance and continuance use of online learning over time.