Miracle-dz/UniFAR-FTUs huggingface dataset:
Enhanced cross-domain document clustering with a semantically enhanced text stemmer (SETS)

The aim of document clustering is to produce coherent clusters of similar documents. Clustering algorithms rely on text normalisation techniques to represent and cluster documents. Although most document clustering algorithms perform well in specific knowledge domains, processing cross-domain document repositories is still a challenge. This paper attempts to address this challenge. It investigates the performance of the sk-means clustering algorithm across domains, by comparing the cluster coherence produced with semantic-based and traditional TF-IDF-based document representations. The evaluation is conducted on 20 different generic sub-domains of a thousand documents, each randomly selected from the Reuters21578 corpus. The experimental results obtained from the evaluation demonstrate improved coherence of clusters produced by using a semantically enhanced text stemmer SETS, when compared to the text normalisation obtained with the Porter stemmer. In addition, semantic-based text normalisation is shown to be resistant to noise, which is often introduced in the index aggregation stage, a stage that acquires features to represent documents.
A survey on auditing techniques used for preserving privacy of data stored on cloud

Providing security to the stored data on the cloud is one of the important challenges in cloud computing. Encrypted data which is stored on the cloud may be viewed or modified by the cloud service provider. To overcome this problem many techniques have been developed but, those cannot guarantee accurately about the security of the stored data. These modifications of the data by the service provider or by others should also be known to the data owner. For such purpose, data tagging technique can be used to audit the data. Auditing is done by using Third Party Auditor (TPA). TPA stores data information of the data owner and challenges to the cloud server, depending upon the data owner request. With the help of such mechanism, TPA can convince both, data owner and cloud server.
Different Frequency Bands in Various Regions of the Brain Play Different Roles in the Onset and Wake-Sleep Stages of Infantile Spasms

Objective: The study aimed to identify the signatures of brain networks using electroencephalogram (EEG) in patients with infantile spasms (IS). Methods Scalp EEGs of subjects with IS were prospectively collected in the first year of life (n = 8; age range 4–8 months; 3 males, 5 females). Ten minutes of ictal and interictal EEGs were clipped and filtered into different EEG frequency bands. The values of each pair of EEG channels were directly compared between ictal with interictal onsets and the sleep-wake phase to calculate IS brain network attributes: characteristic path length (CPL), node degree (ND), clustering coefficient (CC), and betweenness centrality (BC). Results CPL, ND, and CC of the fast waves decreased while BC increased. CPL and BC of the slow waves decreased, while ND and CC increased during the IS ictal onset (P < 0.05). CPL of the alpha decreased, and BC increased during the waking time (P < 0.05). Conclusion The transmission capability of the fast waves, the local connectivity, and the defense capability of the slow waves during the IS ictal onset were enhanced. The alpha band played the most important role in both the global and local networks during the waking time. These may represent the brain network signatures of IS.
Association Between Nutrition Literacy and Overweight/Obesity of Adolescents: A Cross–Sectional Study in Chongqing, China

Objective The burden of overweight and obesity in adolescents is increasing rapidly. This study aimed to assess the association between nutrition literacy and overweight/obesity among adolescents in China. Methods This cross–sectional online study involving adolescents aged 10–18 years was conducted in September 2020 in 239 schools in Chongqing China. Overweight and obese adolescents were determined based on the International Obesity Task Force's recommended age–sex specific body mass index cutoff points. Nutrition literacy was measured using the “Nutrition literacy scale for middle school students in Chongqing (CM–NLS). ” The CM–NLS included three subdomains (functional nutritional literacy, interactive nutrition literacy, and critical nutrition literacy). Multinomial logistic regression model was used to examine the association. Results A total of 18,176 adolescents (49.8% girls) were included. The prevalence of overweight and obesity was 9.6% and 17.0%, respectively. Compared with those having a low nutrition literacy score (below median), those with a high score were less likely to be overweight and obese. The odds ratio (95% CI) for overweight was 0.87 (0.79–0.97) (nutrition literacy) and 0.81 (0.73–0.90) (functional nutritional literacy). The corresponding figures for obesity were 0.84 (0.77–0.91) and 0.73 (0.67–0.80), respectively. Significant interaction existed between grade and nutrition literacy. The inverse association between nutrition literacy and overweight/obesity was significant among those in senior school but not among those in junior high school. Conclusion Nutrition literacy was inversely associated with overweight/obesity among adolescents, especially those attending senior high schools.
Mechanism and control of tooth eruption: overview and clinical implications.

OBJECTIVES To review pre- and post-emergent eruption, with particular emphasis on distinguishing isolated molar ankylosis from primary failure of eruption (PFE) and genetic considerations in eruption problems. MATERIAL AND METHODS Radiographic review of eruption failure patients; animal and human experiments; high precision observations of movements of erupting teeth. RESULTS In pre-emergent tooth eruption, the controlling element is the rate of resorption of overlying structures. A path is cleared, and then the erupting tooth moves along it. This has clinical importance in recognizing the cause of eruption problems, particularly PFE, in which all teeth distal to the most mesial involved tooth do not erupt or respond to orthodontics. In our study of by far the largest sample of PFE cases yet reported, familial cases of PFE accounted for approximately (1/4) of all cases examined. Candidate genes now are being evaluated. In post-emergent eruption, control seems to be light forces of long duration that oppose eruption, rather than heavy forces of short duration such as those during mastication. Studies of human premolars in their passage from gingival emergence to the occlusal plane show that in this phase eruption occurs only during a few hours in the early evening. The critical hours for eruption parallel the time that growth hormone levels are highest in a growing child. In this stage intermittent force does not affect the rate of eruption, but changes in periodontal blood flow do affect it.
Functional analysis of bispecific antibody (EpCAMxCD3)‐mediated T‐lymphocyte and cancer cell interaction by single‐cell force spectroscopy

The atomic force microscopy (AFM) is a powerful tool to analyze forces generated on cellular interactions on the single‐cell level. This highly sensitive device can record changes in force in the pico‐Newton range, which equals single molecule bonds. Here, we have used single‐cell force spectroscopy by AFM to investigate the interaction between T cells and tumor cells that is induced by the bispecific antibody HEA125xOKT3 (specificity anti‐EpCAMxCD3). We show that HEA125xOKT3 induces a specific increase in adhesion force between T cells and cancer cells. The adhesive force that is generated on cell‐cell contact is dependent on the applied force on initial contact and the duration of this initial contact. In summary, HEA125xOKT3 has been found to mediate contact formation by distinct processes. It induces direct cell‐cell interaction, which results in the activation of T‐cell signaling, facilitates the formation of supramolecular activation clusters and ultimately of an immune synapse.
Predictive Value of Ex Vivo Chemosensitivity Assays for Individualized Cancer Chemotherapy: A Meta-Analysis

Current treatment strategies for chemotherapy of cancer patients were developed to benefit groups of patients with similar clinical characteristics. In practice, response is very heterogeneous between individual patients within these groups. Precision medicine can be viewed as the development toward a more fine-grained treatment stratification than what is currently in use. Cell-based drug sensitivity testing is one of several options for individualized cancer treatment available today, although it has not yet reached widespread clinical use. We present an up-to-date literature meta-analysis on the predictive value of ex vivo chemosensitivity assays for individualized cancer chemotherapy and discuss their current clinical value and possible future developments.
Outstanding performance of a nanofilm microstrip antenna

We report on the fabrication of a microstrip antenna with an ultra-thin Iron film patch with thickness of approximately 10 nm. The antenna showed excellent response in terms of performance and reliability. In addition, the antenna demonstrated potential for ultra-wide band applications. Such antennas may therefore have significant promise for system-on-chip, space application, and other specialized applications.
Immune-and Metabolism-Associated Molecular Classiﬁcation of Ovarian Cancer

Ovarian cancer (OV) is a complex gynecological disease, and its molecular characteristics are not clear. In this study, the molecular characteristics of OV subtypes based on metabolic genes were explored through the comprehensive analysis of genomic data. A set of transcriptome data of 2752 known metabolic genes was used as a seed for performing non negative matrix factorization (NMF) clustering. Three subtypes of OV (C1, C2 and C3) were found in analysis. The proportion of various immune cells in C1 was higher than that in C2 and C3 subtypes. The expression level of immune checkpoint genes TNFRSF9 in C1 was higher than that of other subtypes. The activation scores of cell cycle, RTK-RAS, Wnt and angiogenesis pathway and ESTIMATE immune scores in C1 group were higher than those in C2 and C3 groups. In the validation set, grade was significantly correlated with OV subtype C1. Functional analysis showed that the extracellular matrix related items in C1 subtype were significantly different from other subtypes. Drug sensitivity analysis showed that C2 subtype was more sensitive to immunotherapy. Survival analysis of differential genes showed that the expression of PXDN and CXCL11 was significantly correlated with survival. The results of tissue microarray immunohistochemistry showed that the expression of PXDN was significantly correlated with tumor size and pathological grade. Based on the genomics of metabolic genes, a new OV typing method was developed, which improved our understanding of the molecular characteristics of human OV.
Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors

The discoidin domain receptor (DDR1) is characterized by a discoidin I motif in the extracellular domain, an unusually long cytoplasmic juxtamembrane (JM) region, and a kinase domain that is 45% identical to that of the NGF receptor, TrkA. DDR1 also has a major splice form, which has a 37 amino acid insert in the JM region with a consensus Shc PTB site that is lacking in the shorter receptor. One class of ligands for the DDR receptors has recently been identified as being derived from the collagen family, but neither native PC12 cells, which express modest amounts of DDR1, nor trans‐fected PC12 cells, which express much larger amounts of DDR1, respond to this ligand. A chimeric receptor, containing the extracellular domain of hPDGFRβ fused to the transmembrane and intracel‐lular regions of DDR1, also fails to mediate neuro‐nal‐like differentiation in stably transfected PC12 cells and is only weakly autophosphorylated. However, chimeric receptors, which are composed of combinations of intracellular regions from DDR1 and TrkA (with the extracellular domain of hPDGFRβ), in some cases provided ligand (PDGF)‐inducible receptor responses. Those with the TrkA kinase domain and the DDR1 JM regions were able to produce differentiation to varying degrees, whereas the opposite combination did not. Analysis of the signaling responses of the two chimeras with DDR1 JM sequences (with and without the insert) indicated that the shorter sequence bound and activated FRS2 whereas the insert‐containing form activated Shc instead. Both activated PLC γ through the carboxyl‐terminal tyrosine of the TrkA domain (Y785 in TrkA residue numbering). Mutation of this site (Y3 F) eliminated PLC7 activation (indicating there are no other cryptic binding sites for PLC γ in the DDR1 sequences) and markedly reduced the differ‐entiative activity of the receptor. This is in contrast to TrkA (or PDGFRβ/TrkA chimeras), where ablation of this pathway has no notable effect on PC12 cell morphogenic responses. Thus, the activation of FRS2 and Shc (leading to MAPK activation) is weaker in the DDR1/TrkA chimeras than in TrkA alone, and the PLC7 contribution becomes essential for full response. Nonetheless, both DDR1 JM regions contain potentially usable signaling sites, albeit they apparently are not activated directly in DDR1 (or DDR1 chimeras) in a ligand‐dependent fashion. These findings suggest that the DDR1 receptors do have signaling capacity but may require additional components or altered conditions to fully activate their kinase domains and/or sustain the activation of the JM sites. —Foehr, E. D. , Tatavos, A. , Tanabe, E. , Raffioni, S. , Goetz, S. , DiMarco, E. , De Luca, M. , Bradshaw, R. A. Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of jux‐tamembrane domains in PDGFR/DDR/TrkA chi‐meric receptors. FASEB J. 14, 973–981 (2000)
Association of Endothelial and Mild Renal Dysfunction With the Severity of Left Ventricular Hypertrophy in Hypertensive Patients.

BACKGROUND The association between impaired renal function and increase left ventricular mass was shown to be related to increase in arterial stiffness, which indicates that vascular homeostasis and remodeling may impact the left ventricular hypertrophy (LVH) in patients with renal dysfunction. METHODS We measured the peripheral arterial reactive hyperemia index (RHI) and estimated glomerular filtration rate (eGFR) in 317 hypertensive patients comprising 115 normal RHI (RHI > 1.67) and normal eGFR (eGFR ≥ 90ml/min per 1.73 m(2)), 136 low RHI (RHI ≤ 1.67), 27 low eGFR (60 ≤ eGFR < 90ml/min per 1.73 m(2)) and 39 low RHI combined with low eGFR. RESULTS Multivariate logistic regression analysis identified lg RHI (odds ratio (OR): 0.001, 95% confidence interval (CI): 10(-6) to 0.426, P = 0.024) and lg eGFR (OR: 0.009, 95% CI: 10(-4) to 0.414, P = 0.016) as independent factors correlated with LVH respectively in hypertensive patients. Compared with normal RHI and eGFR patients, the extent of LVH in patients with either low RHI (OR: 1.224 95% CI: 0.451 to 3.327, P = 0.691) or low eGFR (OR: 0.593 95% CI: 0.070 to 5.037, P = 0.632) did not significantly increase, while it increased significantly in patients with low RHI combined with low eGFR (OR: 4.629 95% CI: 1.592 to 13.458, P = 0.005). CONCLUSIONS The concurrence of endothelial and mild renal dysfunction was significantly associated with the severity of LVH in hypertensive patients.
A Study about Effectiveness of the Health Promoting Schools Network in Portugal

L'investissement realise par les gouvernements dans le projet du reseau des Ecoles Promotrices de Sante justifie la necessite de dresser un bilan de son impact, et plus particulierement en ce qui concerne les changements survenus dans la dimension organisationnelle de l'ecole, les relations entre ses membres, et entre l'ecole et la communaute, ainsi que les changements dans la capacite de l'ecole a utiliser les ressources locales. Cette etude s'interesse a toutes ces dimensions, en se concentrant surtout sur la question de l'education sexuelle. Celle-ci ayant ete rendue obligatoire dans tout le systeme scolaire publique, une enquete a ete menee aupres des ecoles publiques portugaises huit mois apres publication de la loi la concernant. Cette enquete a permis non seulement de comprendre la facon dont le sujet etait aborde par les ecoles, mais egalement d'analyser l'existence ou non de reelles differences entre les Ecoles Promotrices de Sante et les autres etablissements concernant: 1- l'integration de l'education sexuelle dans le curriculum; 2- les relations ecole/etudiants et famille/communaute; 3- le pouvoir de delivrer l'education sexuelle; 4-l'utilisation des ressources locales. Cette etude d'evaluation a ete menee aupres de 4, 267 ecoles de tous niveaux, dont 841 etaient membre du reseau des Ecoles Promotrices de Sante. Pour une analyse comparative entre les deux groupes d'ecoles (promotrices de sante ou non), des tests du chi carre ont ete conduits sur les differentes variables, utilisant un seuil de signification de . 05. Les differents points analyses ont montre une difference significative entre les deux groupes d'ecoles, avec des resultats plus positifs emergeant des Ecoles Promotrices de Sante. D'autres sources de donnees, telles que certaines donnees qualitatives recoltees aupres de professionnels faisant partie du reseau des Ecoles Promotrices de Sante, confirment les conclusions apportees par cette etude. L'evaluation du resultat de l'intervention de promotion de la sante dans les methodologies, les pratiques et la philosophie des ecoles, requiert davantage d'investissement et des approches multi-methodologiques, y compris de connaitre les perceptions des eleves. Cette etude montre certains resultats positifs par rapport a l'impact de l'investissement en promotion de la sante dans les ecoles. De plus, elle fournit aux professionnels travaillant dans ce domaine des informations qui peuvent s'averer utiles pour la reorientation de leurs strategies de travail.
Creativity/Innovation in Information Systems Organizations Introduction to Session

Creativity as an I.S. minitrack is in its seventh year. Its purpose is to generate a stream of research in an area which has been neglected in the I.S. literature. Prior to the first track session, very few papers had been published on that topic in the 40 year history of I.S. The minitrack includes papers that are theoretical, conceptual or empirical in nature, relating to approaches that will produce, or have resulted in, creativity in the information systems field.
Spermidine in the bacterial cell.

SUMMARY The concentration of spermidine in extracts of various micro-organisms was determined; Neurospora crassa contained the highest concentrations of spermidine, while in Pseudomonas aeruginosa, Escherichia coli and Saccharomyces cerevisiae the concentration of spermidine was lower. Growing organisms and cell-free extracts of the micro-organisms tested were able to synthesize [14C]spermidine from dl-[2-14C]methionine. Cell-free extracts of Pseudomonas aeruginosa were most active in this respect. [14C]Spermidine formed by growing Bacillus subtilis was localized in both the protoplasts and the bacterial cell walls. The kinetics of the adsorption of [14C]spermidine on to cell walls and protoplasts of B. subtilis were also studied. The interpretation of these observations and their relation to the antibacterial effect and growth-promoting activity of spermidine are discussed.
Cryptococcus neoformans: historical curiosity to modern pathogen

The importance of the Basidiomycete Cryptococcus neoformans to human health has stimulated its development as an experimental model for both basic physiology and pathogenesis. We briefly review the history of this fascinating and versatile fungus, some notable aspects of its biology that contribute to virulence, and current tools available for its study. Copyright © 2013 John Wiley & Sons, Ltd.
LYMPHOID NEOPLASIA APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment

The Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; Department of Medicine, Harvard Medical School, Boston, MA; Aduro Biotech Europe (formerly known as BioNovion), Oss, The Netherlands; and Department of Lymphoma & Myeloma, Tianjin Cord Blood Bank, Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
Long-term wind speed prediction based on optimized support vector regression

Wind energy is considered as one of the most remarkably renewable energy origins that reduce the expenditure of electricity production. In the last decade, there are several forecasting speed of wind algorithms that have been to improve prediction reliability. Support Vector Regression (SVR) parameters such as kernel parameter, penalty factor (C) have a great effect on the complexity and reliability of forecasting algorithm. This paper proposed a hybrid approach based on Whale Optimization Algorithm (WOA) and SVR namely WOA-SVR for fixing issues which traditional methods cannot handle effectively and have shown high performance in many respects. The performance of proposed algorithm (WOA-SVR) is evaluated using several different aspects as well as the daily average wind speed data from Space Weather Monitoring Center (SWMC) in Egypt as a case study is used. For verification, the results of the proposed algorithm are compared with Particle Swarm Optimization (PSO) and the original SVR without parameters optimization. The experimental results showed that the proposed WOA-SVR algorithm is capable of finding the optimal values of SVR parameters, avoid local optima problem, and it is competitive for forecasting speed of the wind.
Research on Preventive Maintenance Cycle's Optimization of Complex System

For complex mechanical equipment containing N units the optimal model to preventive maintenance cycle policy is proposed to minimize the maintenance cost rate, the model is subject to the availability and the reliability. And optimal variable is preventive maintenance cycle. The recursion relationship of failure rate before and after imperfect preventive maintenance was built up concerning with the concept of age reduction factor. Finally, immunity particle swarm algorithm is used to solve the model; the result of an example proves the model valid and effective and the cost rate decreases 10.2% than single parts maintenance policy under identical restraint condition.
ThOR: Three-dimensional Object Retrieval Library

Following the increasing number of 3D object collections, researchers developed several algorithms related to 3D object analysis, comparison and retrieval methods. However, there is no simple solution offering researchers and practitioners a framework for the integration of algorithms and techniques developed within this context into their applications and tools. ThOR (Three-dimensional Object Retrieval) is a lightweight open source Java library for content based object retrieval, that provides common 3D shape retrieval indexing and retrieval tools. Most important, it allows addition of new components, such as shape descriptors, with minimal effort. In short, ThOR provides an easy solution for the implementation of 3D object retrieval tools using both local and internet-based client-server architectures.