Miracle-dz/UniFAR-FTUs huggingface dataset:
Laser shock pressing of silver nanowires on flexible substrates to fabricate highly uniform transparent conductive electrode films

Large surface roughness, wire-to-wire junction resistance, and poor adhesion strength of percolated silver nanowire films on polymer substrates are critical issues responsible for low shunt resistance, electron concentration, and thermal damage, resulting in the occurrence of dark spots and damage to flexible electronic devices. Therefore, the fabrication of transparent conductive electrode (TCE) thin films with high surface smoothness and enhanced film properties without the aforementioned problems is essential. Herein, we propose an innovative method to mechanically join silver nanowires on heat-sensitive polymer substrates using a laser-induced shock pressure wave generated by laser ablation of a sacrificial layer. The physical joining mechanism and film properties, that is, sheet resistance, transmittance, adhesion strength, and flexibility, were experimentally analyzed. When a high laser shock pressure was applied to the silver nanowires, plastic deformation occurred; thus, a sintered network film was fabricated through solid-state atomic diffusion at the nanowire junctions. Under optimal process conditions, the sintered films showed high resistance to the adhesion tape test (R/R 0 = 1.15), a significantly reduced surface roughness less than 6 nm, and comparable electrical conductivity (8 ± 2 Ω·sq−1 ) and visible transmittance (84% ± 3%) to typical joining methods. Consequently, this work demonstrates that the laser-induced shock pressing technique has strong potential for the production of TCE metal films on heat-sensitive flexible substrates with film properties superior to those of films produced by conventional methods.
Effect of Distracting Background Speech in an Auditory Brain–Computer Interface

Studies so far have analyzed the effect of distractor stimuli in different types of brain–computer interface (BCI). However, the effect of a background speech has not been studied using an auditory event-related potential (ERP-BCI), a convenient option when the visual path cannot be adopted by users. Thus, the aim of the present work is to examine the impact of a background speech on selection performance and user workload in auditory BCI systems. Eleven participants tested three conditions: (i) auditory BCI control condition, (ii) auditory BCI with a background speech to ignore (non-attentional condition), and (iii) auditory BCI while the user has to pay attention to the background speech (attentional condition). The results demonstrated that, despite no significant differences in performance, shared attention to auditory BCI and background speech required a higher cognitive workload. In addition, the P300 target stimuli in the non-attentional condition were significantly higher than those in the attentional condition for several channels. The non-attentional condition was the only condition that showed significant differences in the amplitude of the P300 between target and non-target stimuli. The present study indicates that background speech, especially when it is attended to, is an important interference that should be avoided while using an auditory BCI.
Dynamic Imaging of Nanostructures in an Electrolyte with a Scanning Electron Microscope

Abstract Abstract The development of microfabricated liquid cells has enabled dynamic studies of nanostructures within a liquid environment with electron microscopy. While such setups are most commonly found in transmission electron microscope (TEM) holders, their implementation in a scanning electron microscope (SEM) offers intriguing potential for multi-modal studies where the large chamber volume allows for the integration of multiple detectors. Here, we describe an electrochemical liquid cell SEM platform that employs the same cells enclosed by silicon nitride membrane windows found in liquid cell TEM holders and demonstrate the imaging of copper oxide nanoparticles in solution using both backscattered and transmitted electrons. In particular, the transmitted electron images collected at high scattering angles show contrast inversion at liquid layer thicknesses of several hundred nanometers, which can be used to determine the presence of liquid in the cell, while maintaining enough resolution to image nanoparticles that are tens of nanometers in size. Using Monte Carlo simulations, we show that both imaging modes have their advantages for liquid phase imaging and rationalize the contrast inversion observed in the transmitted electron image.
Assessment of the accuracy of an intermittent‐scanning continuous glucose monitoring device in patients with type 2 diabetes mellitus undergoing hemodialysis (AIDT2H) study

FreeStyle Libre has been approved for use in patients undergoing hemodialysis (HD) in Japan, unlike Europe and the United States; however, evidence regarding its accuracy in such patients is sparse. Forty‐one participants with type 2 diabetes undergoing HD were recruited. The overall mean absolute relative difference and mean absolute difference were 23.4% and 33.9 mg/dL, respectively. Sensor glucose levels and capillary glucose levels were significantly correlated (r = 0.858, P < .01), although the sensor glucose levels were significantly lower than the capillary glucose levels. The accuracy of FreeStyle Libre in patients undergoing HD became deteriorated with the days of usage. The percentage of sensor results in Zones A and B in the consensus error grid analysis and in the Clarke error grid analysis were 99.7% and 99.0%, respectively. Its insufficient accuracy necessitates adjunct usage of FreeStyle Libre with self‐monitoring of blood glucose in patients undergoing HD.
Long-Term Effectiveness and Tolerability of Pain Treatment with Tapentadol Prolonged Release.

BACKGROUND The central analgesic tapentadol prolonged release (PR) has proven effective and generally well tolerated in a broad range of chronic pain conditions. Long-term data of its use are still scarce. OBJECTIVES To evaluate long-term effectiveness, tolerability, and safety of tapentadol PR in patients with severe chronic osteoarthritis (OA) knee pain or low back pain (LBP) who responded to tapentadol in 1 of 4 preceding 12-week phase 3b clinical trials. STUDY DESIGN Open-label, uncontrolled, observational extension study of up to 72 weeks. SETTING Fourteen centers in Spain. Protocol approval by the reference ethics committee for all the participating centers. METHODS Eligible patients started the extension trial on the tapentadol PR dosage optimized for them in the preceding trial; dose adjustments were permitted throughout the extension. Treatment effectiveness outcomes included changes in pain intensity, sleep, state of health, quality of life, patient and clinician global impression of change, and patients' satisfaction with treatment. Patients with OA knee pain also answered the Western Ontario and McMaster Universities OA index, and patients with LBP with a possible neuropathic pain component completed neuropathic pain-related questionnaires. RESULTS Eighty-three patients were enrolled: 40 with OA knee pain, 43 with LBP. The full analysis set consisted of 81 patients. Mean pain intensity remained relatively stable over the 72-week extension period with mean increases from baseline of 0.44 (95% confidence interval [CI], -0.1,1.0; Numeric Rating Scale) for all patients, 0.2 (95% CI, -0.5, 0.9) for patients with OA, and 0.68 (95% CI, -0.2, 1.6) for patients with LBP. State of health and quality of life baseline ratings were maintained; overall impression of change was "improved. " Most patients (88.9%) reported at least good treatment satisfaction at the end of treatment. Mean daily tapentadol PR doses slightly increased from 313.3 ± 139.5 mg at baseline to 315.7 ± 140.1 mg at end of study. Uptitration was required for 8.4% of the patients, 4.8% had a dose reduction during the trial. Adverse events considered probably/likely or certainly related to tapentadol PR treatment by the investigator were documented for 18.1% of all patients, most commonly constipation (7.2%). Seven patients (8.4%) experienced adverse events leading to premature discontinuation. LIMITATIONS An open-label design, stable concomitant analgesics (World Health Organization step I), and dose adjustments were allowed during the study. All patients had benefitted from tapentadol PR in preceding trials. CONCLUSIONS Sustained pain relief and quality of life for up to 72 treatment weeks under relatively stable dosing, as well as the good safety profile, indicate the usefulness of tapentadol PR for patients who suffer from severe chronic OA knee pain and LBP with limited risk for tolerance development.
Novel Nanofluidic Cells Based on Nanowires and Nanotubes for Advanced Chemical and Bio-Sensing Applications

Since the first introduction of one-dimensional nanochannels for single-molecule detection, there has been increasing interest in modern nanofluidic systems, such as chemical and biological sensing applications. Recently developed nanowires (NWs) and nanotubes (NTs) have received tremendous attention due to their unique geometrical, physical and chemical properties, which are very attractive in this field. Here, we review the recent research activities in the field of novel nanofluidic cells based on NWs and NTs. First, we give a brief introduction of this field. Then the common synthesis methods of NWs and NTs are summarized. After that, we discuss the working principle and sensing mechanism of nanofluidic devices, which is fundamental to the interaction between these nanostructures and small molecules. Finally, we present the NW- and NT-based devices for chemical and bio-sensing applications, such as gas sensing, pathogen detection, DNA sequencing, and so forth.
The mediational effect of social support between organizational identification and employees’ health: a three-wave study on the social cure model

ABSTRACT Background Recent research postulated that organizational identification plays an important role in employees’ health and well-being. Building on the Social Identity Approach as a framework, we test the so-called social cure hypothesis, according to which group-based processes of social support should reduce employees’ psychological distress. Design and Methods While there is a considerable amount of cross-sectional evidence concerning the positive role played by organizational identification in this dynamic, there is a lack of full panel studies. This study tries to fill this gap by using data from a sample of technical and administrative staff of a University in Italy at three time points (N = 96). Data were analyzed using Autoregressive Cross-Lagged Panel models. Results We found support for the hypothesized longitudinal mediational model. Specifically, strongly identified employees tend to receive more social support, and this in turn reduces psychological distress over time. Conclusions This study is the first test of the social cure hypothesis in an organizational context that uses a panel study design. We discuss the theoretical and practical implications for management.
Issues in the Quantitation of Functional Groups by FTIR Spectroscopic Analysis of Impactor-Collected Aerosol Samples

Fourier Transform Infrared (FTIR) spectroscopy is used to complement total carbon and molecular level measurements in the study of organic particulate matter because it is a relatively simple analytical procedure that provides chemically useful details (i.e., functional group and bond information) missing in total carbon measurements. FTIR characterizes the entire aerosol, whereas molecular methods identify only a small fraction of the organic mass. The need to measure the size-resolved chemical composition of ambient aerosols often necessitates the collection of aerosol samples with a single-jet impactor, such as a Hering low pressure impactor (LPI). Single-jet impactor samples have a nonuniform (conical) deposit geometry that results in a variable and inconsistent path length across the sample deposit and may also result in the enhancement of infrared beam scattering. This makes quantitation of LPI samples by traditional procedures based on Beer's Law impossible. Therefore we applied a ratio method developed by Cliff and Lorimer (1972) for energy dispersive spectroscopy to FTIR analyses of LPI samples. In this study the prospects and limitations for quantitative measurement of functional groups by FTIR spectroscopic analysis of impactor-collected aerosol samples is examined using laboratory-generated standards and size-segregated samples collected with a LPI in the Smoky Mountains. FTIR spectroscopy provides semiquantitative estimates of functional group concentrations (precision ∼50%) in aerosol samples. However, Infrared (IR) beam scattering due to the physical geometry of impactor deposits is a significant source of uncertainty, and concentrations of some functional groups appear to be substantially underestimated due to the "clipping" of high wave number IR peaks by rising baselines. The rising baselines result from increases in IR beam scattering with wave number and are related to the sample deposit geometry. Future sampling or analytical methodologies must overcome the bias that results from irregular sample deposit geometry.
Interplay of Nutrients, Temperature, and Competition of Native and Alien Cyanobacteria Species Growth and Cyanotoxin Production in Temperate Lakes

Global warming and eutrophication contribute to formation of HABs and distribution of alien cyanobacteria northward. The current study assessed how alien to Europe Sphaerospermopsis aphanizomenoides and Chrysosporum bergii will co-occur with dominant native Planktothrix agardhii and Aphanizomenon gracile species under changing conditions in temperate freshwaters. The experiments were carried out to examine the effect of nutrients and temperature on the growth rate of cyanobacteria, production of cyanotoxins, and interspecies competition. The highest growth rate was determined for A. gracile (0.43 day−1) and S. aphanizomenoides (0.40 day−1) strains at all the tested nutrient concentrations (IP and IN were significant factors). S. aphanizomenoides adapted to the wide range of nutrient concentrations and temperature due to high species ecological plasticity; however, A. gracile was able to suppress its dominance under changing conditions. Regularity between tested variables and STX concentration in A. gracile was not found, but IP concentration negatively correlated with the amount of dmMC-RR and other non-ribosomal peptides (NRPs) in P. agardhii strains. The relative concentration of NRPs in nontoxic P. agardhii strain was up to 3-fold higher than in MC-producing strain. Our study indicated that nutrients, temperature, and species had significant effects on interspecies competition. A. gracile had a negative effect on biomass of both alien species and P. agardhii.
Identification and initial characterization of POLIII-driven transcripts by msRNA-sequencing

ABSTRACT Non-coding RNAs (ncRNAs) are powerful regulators of gene expression but medium-sized (50–300 nts in length) ncRNAs (msRNAs) are barely picked-up precisely by RNA-sequencing. Here we describe msRNA-sequencing (msRNAseq), a modified protocol that associated with a computational analyses pipeline identified about ~1800 msRNA loci, including over 300 putatively novel msRNAs, in human and murine cells. We focused on the identification and initial characterization of three POLIII-derived transcripts. The validation of these uncharacterized msRNAs identified an ncRNA in antisense orientation from the POLR3E locus transcribed by POLIII. This msRNA, termed POLAR (POLR3E Antisense RNA), has a strikingly short half-life, localizes to paraspeckles (PSPs) and associates with PSP-associated proteins indicating that msRNAseq identifies functional msRNAs. Thus, our analyses will pave the way for analysing the roles of msRNAs in cells, development and diseases.
Short‐circuit diffusion of ultrasonic bonding interfaces in microelectronic packaging

To enhance the development of ultrasonic bonding, an improved understanding of the process taking place at the bond interface is needed. In this article, cross‐section features of an ultrasonic bonding area were inspected using a high resolution transmission electron microscope (HRTEM). Results show that ultrasonic vibration activates dislocations inside the metal crystalline lattice, which are the fast diffusion channels. Diffusion mechanism of dislocation channels in ultrasonic bonding is more prominent than crystal diffusion when the temperature is relatively low. For the given ultrasonic bonding parameters, depth of atom diffusion at interface of ultrasonic bonding was about 200 nm, and it is an intermetallic compound of AuAl2 at AuAl diffusing interface. These will be helpful for further analysis. Copyright © 2008 John Wiley & Sons, Ltd.
Quantifying Charge Effects on Fouling Layer Strength and (Ir)Removability during Cross-Flow Microfiltration

Fouling of membranes is still an important limiting factor in the application of membrane technology. Therefore, there is still a need for an in-depth understanding of which parameters affect the (ir)removability of fouling layers, as well as the mechanisms behind fouling. In this study, fluid dynamic gauging (FDG) was used to investigate the influence of charge effects between negatively charged foulant particles and cations on cake cohesive strength. Fouling cakes’ thicknesses and cohesive strengths were estimated during membrane operations, where microfiltration (MF) membranes were fouled in a feed-and-bleed cross-flow filtration system with low and highly negatively charged polystyrene–polyacrylic acid core-shell particles. In addition, an added procedure to determine the irremovability of cakes using FDG was also proposed. Comparing layers formed in the presence and absence of calcium ions revealed that layers formed without calcium ions had significantly lower cohesive strength than layers formed in the presence of calcium ions, which is explained by the bridging effect between negatively charged particles and calcium ions. Results also confirmed more cohesive cakes formed by high negative charge particles in the presence of calcium compared to lower negative charge particles. Hence, it was demonstrated that FDG can be used to assess the cohesive strength ((ir)removability) of cake layers, and to study how cake cohesive strength depends on foulant surface charge and ionic composition of the solution.
Human Adipose Tissue-Derived Mesenchymal Stromal Cells Inhibit CD4+ T Cell Proliferation and Induce Regulatory T Cells as Well as CD127 Expression on CD4+CD25+ T Cells

Mesenchymal stromal cells (MSC) exert their immunomodulatory potential on several cell types of the immune system, affecting and influencing the immune response. MSC efficiently inhibit T cell proliferation, reduce the secretion of pro-inflammatory cytokines, limit the differentiation of pro-inflammatory Th subtypes and promote the induction of regulatory T cells (Treg). In this study, we analyzed the immunomodulatory potential of human adipose tissue-derived MSC (ASC), on CD4+ T cells, addressing potential cell-contact dependency in relation to T cell receptor stimulation of whole human peripheral blood mononuclear cells (PBMC). ASC were cultured with not stimulated or anti-CD3/CD28-stimulated PBMC in direct and transwell cocultures; PBMC alone were used as controls. After 7 days, cocultures were harvested and we analyzed: (1) the inhibitory potential of ASC on CD4+ cell proliferation and (2) phenotypic changes in CD4+ cells in respect of Treg marker (CD25, CD127 and FoxP3) expression. We confirmed the inhibitory potential of ASC on CD4+ cell proliferation, which occurs upon PBMC stimulation and is mediated by indoleamine 2,3-dioxygenase. Importantly, ASC reduce both pro- and anti-inflammatory cytokine secretion, without indications on specific Th differentiation. We found that stimulation induces CD25 expression on CD4+ cells and that, despite inhibiting overall CD4+ cell proliferation, ASC can specifically induce the proliferation of CD4+CD25+ cells. We observed that ASC induce Treg (CD4+CD25+CD127−FoxP3+) only in not stimulated cocultures and that ASC increase the ratio of CD4+CD25+CD127+FoxP3− cells at the expense of CD4+CD25+CD127−FoxP3− cells. Our study provides new insights on the interplay between ASC and CD4+ T cells, proposing that ASC-dependent induction of Treg depends on PBMC activation which affects the balance between the different subpopulations of CD4+CD25+ cells expressing CD127 and/or FoxP3.
Pengaruh Kadar NaCl Terhadap Hasil dan Mutu Buah Tomat (Lycopersicum esculentum Mill.)

Tomat merupakan tanaman hortikultura yang bersifat moderat sensitif terhadap salinitas dengan batas toleransi 1,3-6 dS/m. Akhir-akhir ini, kualitas air irigasi mengalami penurunan karena akumulasi mineral garam dari intrusi air laut dan residu pupuk. Namun, penyiraman dengan air salin dapat meningkatkanmutu buah tomat (Yin et al., 2010). Oleh karena itu, pengaruh penyiraman larutan NaCl terhadap pertumbuhan dan hasil dua varietas tomat menjadi tujuan dari penelitian ini. Penelitian disusun dalam Rancangan Acak Lengkap, terdiri dari dua faktor. Faktor pertama adalah kadar penyiraman larutan NaCl, yaitu 0, 2500, 5000, dan 7500 ppm. Faktor kedua adalah varietas tomat, yaitu ‘Warani’ dan ‘Permata’. Penyiraman NaCl dilakukan sejak tanaman berbunga sampai panen, dengan interval tiga hari sekali. Respon tanaman terhadap penyiraman NaCl dievaluasi dengan mengamati pertumbuhan tanaman, komponen hasil, dan kualitas hasil tomat. Hasil penelitian menunjukka n bahwa tidak ada interaksi antara kadar NaCl dengan varietas tomat. Pertumbuhan tanaman (bobot kering akar dan kandungan klorofil), hasil, dan mutu buah tomat (padatan terlarut total) meningkat pada pemberian NaCl sebesar 2500 ppm apabila dibandingkan dengan tanaman yang tidak diberi perlakuan NaCl (kontrol), tetapi pertumbuhan tanaman menurun ketika tanaman diberi perlakuan NaCl sebesar 5000 ppm dan 7500 ppm. Kadar NaCl yang optimum untuk meningkatkan mutu buah tomat adalah sebesar 2500 ppm. Pada umumnya, ‘Warani’ dan ‘Permata’ memiliki pertumbuhan, hasil, dan mutu buah yang sama.
Numerical Study of Nanoparticle Deposition in a Gaseous Microchannel under the Influence of Various Forces

Nanoparticle deposition in microchannel devices inducing contaminant clogging is a serious barrier to the application of micro-electro-mechanical systems (MEMS). For micro-scale gas flow fields with a high Knudsen number (Kn) in the microchannel, gas rarefaction and velocity slip cannot be ignored. Furthermore, the mechanism of nanoparticle transport and deposition in the microchannel is extremely complex. In this study, the compressible gas model and a second-order slip boundary condition have been applied to the Burnett equations to solve the flow field issue in a microchannel. Drag, Brownian, and thermophoretic forces are concerned in the motion equations of particles. A series of numerical simulations for various particle sizes, flow rates, and temperature gradients have been performed. Some important features such as reasons, efficiencies, and locations of particle deposition have been explored. The results indicate that the particle deposition efficiency varies more or less under the actions of forces such as Brownian force, thermophoretic force, and drag force. Nevertheless, different forces lead to different particle motions and deposition processes. Brownian or thermophoretic force causes particles to move closer to the wall or further away from it. The drag force influence of slip boundary conditions and gas rarefaction changes the particles’ residential time in the channel. In order to find a way to decrease particle deposition on the microchannel surface, the deposition locations of different sizes of particles have been analyzed in detail under the action of thermophoretic force.