Miracle-dz/UniFAR-FTUs huggingface dataset:
Fluidization of collisionless plasma turbulence

Significance Two textbook physical processes compete to thermalize turbulent fluctuations in collisionless plasmas: Kolmogorov’s “cascade” to small spatial scales, where dissipation occurs, and Landau’s damping, which transfers energy to small scales in velocity space via “phase mixing,” also leading to dissipation. We show that, in a magnetized plasma, another textbook process, plasma echo, brings energy back from phase space and on average, cancels the effect of phase mixing. Energy cascades effectively as it would in a fluid system, and thus, Kolmogorov wins the competition with Landau for the free energy in a collisionless turbulent plasma. This reaffirms the universality of Kolmogorov’s picture of turbulence and explains, for example, the broad Kolmogorov-like spectra of density fluctuations observed in the solar wind. In a collisionless, magnetized plasma, particles may stream freely along magnetic field lines, leading to “phase mixing” of their distribution function and consequently, to smoothing out of any “compressive” fluctuations (of density, pressure, etc.). This rapid mixing underlies Landau damping of these fluctuations in a quiescent plasma—one of the most fundamental physical phenomena that makes plasma different from a conventional fluid. Nevertheless, broad power law spectra of compressive fluctuations are observed in turbulent astrophysical plasmas (most vividly, in the solar wind) under conditions conducive to strong Landau damping. Elsewhere in nature, such spectra are normally associated with fluid turbulence, where energy cannot be dissipated in the inertial-scale range and is, therefore, cascaded from large scales to small. By direct numerical simulations and theoretical arguments, it is shown here that turbulence of compressive fluctuations in collisionless plasmas strongly resembles one in a collisional fluid and does have broad power law spectra. This “fluidization” of collisionless plasmas occurs, because phase mixing is strongly suppressed on average by “stochastic echoes,” arising due to nonlinear advection of the particle distribution by turbulent motions. Other than resolving the long-standing puzzle of observed compressive fluctuations in the solar wind, our results suggest a conceptual shift for understanding kinetic plasma turbulence generally: rather than being a system where Landau damping plays the role of dissipation, a collisionless plasma is effectively dissipationless, except at very small scales. The universality of “fluid” turbulence physics is thus reaffirmed even for a kinetic, collisionless system.
Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation

Abstract BACKGROUND Initially identified as suppressors of metastasis in various types of cancer, kisspeptins are a family of neuropeptides that are key regulators of the mammalian reproductive axis. Accumulating evidence has shown that kisspeptin is able to control both the pulsatile and surge GnRH release, playing fundamental roles in female reproduction, which include the secretion of gonadotropins, puberty onset, brain sex differentiation, ovulation and the metabolic regulation of fertility. Furthermore, recent studies have demonstrated the involvement of the kisspeptin system in the processes of implantation and placentation. This review summarizes the current knowledge of the pathophysiological role and utility of these local placental regulatory factors as potential biomarkers during the early human gestation. OBJECTIVE AND RATIONALE A successful pregnancy, from the initiation of embryo implantation to parturition, is a complex process that requires the orchestration of a series of events. This review aims to concisely summarize what is known about the role of the kisspeptin system in implantation, placentation, early human pregnancy and pregnancy-related disorders, and to develop strategies for predicting, diagnosing and treating these abnormalities. SEARCH METHODS Using the PubMed and Google Scholar databases, we performed comprehensive literature searches in the English language describing the advancement of kisspeptins and the kisspeptin receptor (KISS1R) in implantation, placentation and early pregnancy in humans, since its initial identification in 1996 and ending in July 2018. OUTCOMES Recent studies have shown the coordinated spatial and temporal expression patterns of kisspeptins and KISS1R during human pregnancy. The experimental data gathered recently suggest putative roles of kisspeptin signaling in the regulation of trophoblast invasion, embryo implantation, placentation and early pregnancy. Dysregulation of the kisspeptin system may negatively affect the processes of implantation as well as placentation. Clinical studies indicate that the circulating levels of kisspeptins or the expression levels of kisspeptin/KISS1R in the placental tissues may be used as potential diagnostic markers for women with miscarriage and gestational trophoblastic neoplasia. WIDER IMPLICATIONS Comprehensive research on the pathophysiological role of the kisspeptin/KISS1R system in implantation and placentation will provide a dynamic and powerful approach to understanding the processes of early pregnancy, with potential applications in observational and analytic screening as well as the diagnosis, prognosis and treatment of implantation failure and early pregnancy-related disorders.
Storing Digital Information in Long-Read DNA

There is urgent need for effective and cost-efficient data storage, as the worldwide requirement for data storage is rapidly growing. DNA has introduced a new tool for storing digital information. Recent studies have successfully stored digital information, such as text and gif animation. Previous studies tackled technical hurdles due to errors from DNA synthesis and sequencing. Studies also have focused on a strategy that makes use of 100‒150-bp read sizes in both synthesis and sequencing. In this paper, we a suggest novel data encoding/decoding scheme that makes use of long-read DNA (~1,000 bp). This enables accurate recovery of stored digital information with a smaller number of reads than the previous approach. Also, this approach reduces sequencing time.
Drug-Use and Post-Operative Mortality Following Valve Surgery for Infective Endocarditis: A Systematic Review and Meta-Analysis.

Objective Infective endocarditis (IE) often requires surgical intervention. An increasingly common cause of infective endocarditis is injection drug use (IDU-IE). There is conflicting evidence on whether post-operative mortality differs between people with IDU-IE and people with IE from etiologies other than injection drug use (nonIDU-IE). In this manuscript, we compare short-term postoperative mortality in IDU-IE vs. nonIDU-IE through systematic review and meta-analysis. Methods The review was conducted according to the Cochrane Handbook for Systematic Reviews of Interventions and PRISMA guidelines. Publication databases were queried for key terms included in articles up to September, 2017. Randomized controlled trials, prospective cohorts, or retrospective cohorts that reported on 30-day mortality or in-hospital/operative mortality following valve surgery and that compared outcomes between IDU-IE and nonIDU-IE were included. Results Thirteen studies with 1593 patients (n=341, 21.4% IDU-IE) were included in the meta-analysis. IDU-IE patients more frequently had tricuspid valve infection, Staphylococcus infection, and heart failure before surgery. Meta-analysis revealed no statistically significant difference in 30-day post-surgical mortality or in-hospital mortality between the two groups. Conclusions Despite differing pre-operative clinical characteristics, early post-operative mortality does not differ between IDU-IE and nonIDU-IE patients who undergo valve surgery. Future research on long-term outcomes following valve replacement is needed to identify opportunities for improved healthcare delivery with IDU-IE.
Improvement of Electrical Performance in P-Channel LTPS Thin-Film Transistor with a-Si:H Surface Passivation

We report the effects of surface passivation by depositing a hydrogenated amorphous silicon (a-Si:H) layer on the electrical characteristics of low temperature polycrystalline silicon thin film transistors (LTPS TFTs). The intrinsic a-Si:H layer was optimized by hydrogen dilution and its structural and electrical characteristics were investigated. The a-Si:H layer in the transition region between a-Si:H and µc-Si:H resulted in superior device characteristics. Using a-Si:H passivation layer, the field-effect mobility of the LTPS TFT was increased by 78.4% compared with conventional LTPS TFT. Moreover, the leakage current measured at VGS of 5 V was suppressed because the defect sites at the poly-Si grain boundaries were well passivated. Our passivation layer, which allows thorough control of the crystallinity and passivation-quality, should be considered as a candidate for high performance LTPS TFTs.
Molecular Networking Reveals Two Distinct Chemotypes in Pyrroloiminoquinone-Producing Tsitsikamma favus Sponges

The temperate marine sponge, Tsitsikamma favus, produces pyrroloiminoquinone alkaloids with potential as anticancer drug leads. We profiled the secondary metabolite reservoir of T. favus sponges using HR-ESI-LC-MS/MS-based molecular networking analysis followed by preparative purification efforts to map the diversity of new and known pyrroloiminoquinones and related compounds in extracts of seven specimens. Molecular taxonomic identification confirmed all sponges as T. favus and five specimens (chemotype I) were found to produce mainly discorhabdins and tsitsikammamines. Remarkably, however, two specimens (chemotype II) exhibited distinct morphological and chemical characteristics: the absence of discorhabdins, only trace levels of tsitsikammamines and, instead, an abundance of unbranched and halogenated makaluvamines. Targeted chromatographic isolation provided the new makaluvamine Q, the known makaluvamines A and I, tsitsikammamine B, 14-bromo-7,8-dehydro-3-dihydro-discorhabdin C, and the related pyrrolo-ortho-quinones makaluvamine O and makaluvone. Purified compounds displayed different activity profiles in assays for topoisomerase I inhibition, DNA intercalation and antimetabolic activity against human cell lines. This is the first report of makaluvamines from a Tsitsikamma sponge species, and the first description of distinct chemotypes within a species of the Latrunculiidae family. This study sheds new light on the putative pyrroloiminoquinone biosynthetic pathway of latrunculid sponges.
The concomitant use of tyrosine kinase inhibitors and proton pump inhibitors: Prevalence, predictors, and impact on survival and discontinuation of therapy in older adults with cancer

The concomitant use of tyrosine kinase inhibitors (TKIs) and proton pump inhibitors (PPIs) is a significant concern because of potential drug‐drug interaction that reduces TKI absorption, thus potentially reducing the effectiveness of TKIs. The objective of this study was to evaluate the prevalence and predictors of concomitant TKI‐PPI receipt and its impact on survival and therapy discontinuation in older adults with cancer.
Blood pressure variability in hypertensive patients with atrial fibrillation in the VALUE trial

Abstract Purpose: Blood pressure variability is associated with traditional cardiovascular risk factors, but little is known about the association with atrial fibrillation. We compared blood pressure variability in patients with and without atrial fibrillation using data from the Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial. Materials and methods: The VALUE trial was a randomised-controlled trial of valsartan versus amlodipine in patients with hypertension and high cardiovascular risk, followed for 4.2 years (mean). For the present analysis we included patients with electrocardiogram at baseline and during follow-up, and ≥3 visits from 6 months onwards. We compared standard deviation (SD) of all blood pressures within each visit averaged across all visits (within-visit variability) and of mean blood pressure at each visit (visit-to-visit variability) in patients with and without atrial fibrillation at baseline. We similarly compared patients who developed non-persistent or persistent atrial fibrillation during follow-up with those who did not, using t-tests, ANOVA and linear regression. Results: Of 15,245 patients in the VALUE trial, 13,827 were eligible for analysis. SD of visit-to-visit systolic blood pressure was not significantly different between patients with and without atrial fibrillation at baseline (mean difference 0.3 mm Hg, p = 0.4), but significantly higher in patients with incident non-persistent or persistent atrial fibrillation during follow-up than in those who never developed atrial fibrillation (differences 1.2 and 1.8 mm Hg, respectively, p-values <0.0001). Associations with non-persistent and persistent atrial fibrillation were confirmed in linear regression models (p-values <0.0001). SD of within-visit systolic blood pressure was not significantly different between patients with and without atrial fibrillation at baseline (p = 0.4) but significantly higher in patients with persistent atrial fibrillation during follow-up (p = 0.04). Conclusion: In patients treated for hypertension, atrial fibrillation was not associated with increased blood pressure variability, but blood pressure variability was higher in those who developed atrial fibrillation during follow-up.
Network Analyses of Integrated Differentially Expressed Genes in Papillary Thyroid Carcinoma to Identify Characteristic Genes

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Identifying characteristic genes of PTC are of great importance to reveal its potential genetic mechanisms. In this paper, we proposed a framework, as well as a measure named Normalized Centrality Measure (NCM), to identify characteristic genes of PTC. The framework consisted of four steps. First, both up-regulated genes and down-regulated genes, collectively called differentially expressed genes (DEGs), were screened and integrated together from four datasets, that is, GSE3467, GSE3678, GSE33630, and GSE58545; second, an interaction network of DEGs was constructed, where each node represented a gene and each edge represented an interaction between linking nodes; third, both traditional measures and the NCM measure were used to analyze the topological properties of each node in the network. Compared with traditional measures, more genes related to PTC were identified by the NCM measure; fourth, by mining the high-density subgraphs of this network and performing Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, several meaningful results were captured, most of which were demonstrated to be associated with PTC. The experimental results proved that this network framework and the NCM measure are useful for identifying more characteristic genes of PTC.
Keeping the Result in Sight and Mind: General Cognitive Principles and Language-Specific Influences in the Perception and Memory of Resultative Events

We study how people attend to and memorize endings of events that differ in the degree to which objects in them are affected by an action: Resultative events show objects that undergo a visually salient change in state during the course of the event (peeling a potato), and non-resultative events involve objects that undergo no, or only partial state change (stirring in a pan). We investigate general cognitive principles, and potential language-specific influences, in verbal and nonverbal event encoding and memory, across two experiments with Dutch and Estonian participants. Estonian marks a viewer's perspective on an event's result obligatorily via grammatical case on direct object nouns: Objects undergoing a partial/full change in state in an event are marked with partitive/accusative case, respectively. Therefore, we hypothesized increased saliency of object states and event results in Estonian speakers, as compared to speakers of Dutch. Findings show (a) a general cognitive principle of attending carefully to endings of resultative events, implying cognitive saliency of object states in event processing; (b) a language-specific boost on attention and memory of event results under verbal task demands in Estonian speakers. Results are discussed in relation to theories of event cognition, linguistic relativity, and thinking for speaking.
TiO2 Modification with Transition Metallic Species (Cr, Co, Ni, and Cu) for Photocatalytic Abatement of Acetic Acid in Liquid Phase and Propene in Gas Phase

The commercial P25 titania has been modified with transition metallic species (Cr, Co, Ni, and Cu), added by impregnation with aqueous solutions of the corresponding nitrates. The preparation procedure also includes a heat treatment (500 °C) in argon to decompose the nitrates, remove impurities and to strengthen the metal⁻TiO₂ interaction. The catalysts have been thoroughly characterized using N₂ adsorption, scanning electron microscopy (SEM), X-ray diffraction (XRD), UV-visible diffuse-reflectance spectroscopy (UV-vis DRS) and X-ray photoelectron spectroscopy (XPS), and have been tested in the aqueous phase decomposition of acetic acid and in the gas phase oxidation of propene, using an irradiation source of 365 nm in both cases. The photocatalytic activity of the four metal-containing catalysts varies with the nature of the metallic species and follows a similar trend in the two tested reactions. The effect of the nature of the added metallic species is mainly based on the electrochemical properties of the supported species, being Cu/P25 (the sample that contains copper) the best performing catalyst. In the photodecomposition of acetic acid, all the metal-containing samples are more active than bare P25, while in the gas phase oxidation of propene, bare P25 is more active. This has been explained considering that the rate-determining steps are different in gas and liquid media.
Validation of the extended thrombolysis in cerebral infarction score in a real world cohort

Background A thrombolysis in cerebral infarction (TICI) score of 2b is defined as a good recanalization result although the reperfusion may only cover 50% of the affected territory. An additional mTICI2c category was introduced to further differentiate between mTICI scores. Despite the new mTICI2c category, mTICI2b still covers a range of 50–90% reperfusion which might be too imprecise to predict neurological improvement after therapy. Aim To compare the 7-point “expanded TICI” (eTICI) scale with the traditional mTICI in regard to predict functional independence at 90 days. Methods Retrospective review of 225 patients with large artery occlusion. Angiograms were graded by 2 readers according the 7-point eTICI score (0% = eTICI0; reduced clot = eTICI1; 1–49% = eTICI2a, 50–66% = eTICI2b50; 67–89% = eTICI2b67, 90–99% = eTICI2c and complete reperfusion = eTICI3) and the conventional mTICI score. The ability of e- and mTICI to predict favorable outcome at 90days was compared. Results Given the ROC analysis eTICI was the better predictor of favorable outcome (p-value 0.047). Additionally, eTICI scores 2b50, 2b67 and 2c (former mTICI2b) were significantly superior at predicting the probability of a favorable outcome at 90 days after endovascular therapy with a p-value of 0.033 (probabilities of 17% for mTICI2b50, 24% for mTICI2b67 and 54% for mTICI2c vs. 36% for mTICI2b). Conclusions The 7-point eTICI allows for a more accurate outcome prediction compared to the mTICI score because it refines the broad range of former mTICI2b results.
Study on the hydro-mechanical behavior of fiber reinforced fine grained soils, with application to the preservation of historical monuments

Ziel dieser Arbeit ist es, die Grundlagen zu legen, den Aufstieg der Feuchtigkeit in einem Mauerwerk aus Lehmziegeln in Abhangigkeit der Zeit zu beschreiben und den Einfluss des erhohten Wassergehaltes auf die Scherfestigkeit von Lehmziegeln mit und ohne Bewehrung aus naturlichen Fasern zu erfassen. Aufbauend auf diesen Grundlagen wird die Wirksamkeit ausgewahlter Gegenmasnahmen untersucht. Um den Feuchtetransport in dem feinkornigen Bodenmaterial der Lehmziegel beschreiben zu konnen wird die SWCC experimentell bestimmt und der Einfluss von Bewehrung aus Naturfasern auf diese ermittelt und diskutiert. Scherfestigkeit reprasentativer Materialien wird aus Biaxialversuchen in Abhangigkeit des Wassergehaltes und der damit verbundenen Saugspannungen sowie des Bewehrungsgehaltes abgeleitet. Mit einem numerischen Modell werden die Anschauungsversuche nachgerechnet. Der Vergleich der Ergebnisse zeigt, dass das numerische Modell in der Lage ist, die beobachteten Phanomene abzubilden.
Intermittent Hypoxia Disrupts Adult Neurogenesis and Synaptic Plasticity in the Dentate Gyrus

Individuals with sleep apnea often exhibit changes in cognitive behaviors consistent with alterations in the hippocampus. It is hypothesized that adult neurogenesis in the dentate gyrus is an ongoing process that maintains normal hippocampal function in many mammalian species, including humans. However, the impact of chronic intermittent hypoxia (IH), a principal consequence of sleep apnea, on hippocampal adult neurogenesis remains unclear. Using a murine model, we examined the impact of 30 d of IH (IH30) on adult neurogenesis and synaptic plasticity in the dentate gyrus. Although IH30 did not affect paired-pulse facilitation, IH30 suppressed long-term potentiation (LTP). Immunohistochemical experiments also indicate that IH perturbs multiple aspects of adult neurogenesis. IH30 increased the number of proliferating Sox2+ neural progenitor cells in the subgranular zone yet reduced the number of doublecortin-positive neurons. Consistent with these findings, cell lineage tracing revealed that IH30 increased the proportion of radial glial cells in the subgranular zone, yet decreased the proportion of adult-born neurons in the dentate gyrus. While administration of a superoxide anion scavenger during IH did not prevent neural progenitor cell proliferation, it mitigated the IH-dependent suppression of LTP and prevented adult-born neuron loss. These data demonstrate that IH causes both reactive oxygen species-dependent and reactive oxygen species-independent effects on adult neurogenesis and synaptic plasticity in the dentate gyrus. Our findings identify cellular and neurophysiological changes in the hippocampus that may contribute to cognitive and behavioral deficits occurring in sleep apnea. SIGNIFICANCE STATEMENT Individuals with sleep apnea experience periods of intermittent hypoxia (IH) that can negatively impact many aspects of brain function. Neurons are continually generated throughout adulthood to support hippocampal physiology and behavior. This study demonstrates that IH exposure attenuates hippocampal long-term potentiation and reduces adult neurogenesis. Antioxidant treatment mitigates these effects indicating that oxidative signaling caused by IH is a significant factor that impairs synaptic plasticity and reduces adult neurogenesis in the hippocampus.