Miracle-dz/UniFAR-FTUs huggingface dataset:
Transitional first-grade referrals: An analysis of school-related factors and children's characteristics.

In this study, the relationship among transitional first-grade referrals, school characteristics, and children's personal and school readiness characteristics was examined. Teachers who reported a higher emphasis on didactic instruction tended to refer more children to the transition room. In addition, there were lower levels of involvement for parents of transition-referred children. Moreover, referred children were younger, evaluated their own school abilities less favorably, scored lower on the Gesell Developmental Assessment, and were described by their teachers as less competent academically and less well adjusted socially. The referral of children to a readiness-transitional program is a complex process. Embedded in a sociocultural context, this process is shaped by many forces, including the school system's philosophies and structures; the teachers' views, beliefs, and activities; the family-school connection; and children's skills and characteristics. Despite the controversy surrounding the issue of nonpromotion and its variant, the transition room, school districts across the nation continue to promote these placements as sound educational choices for at-risk students. Seventy-two percent of U.S. schools use transition rooms, kindergarten retention, or both (Love, Logue, Trudeau, & Thayer, 1992). As an alternative to first-grade placement, schools with transition programs assign 13% of their kindergartners to these classrooms (Love et al., 1992). This figure is higher in some states (i.e., New Hampshire) where the average transition room placement of children is reported to be approximately 28% (Gredler, 1992).
Effect of Sodium Hypophosphite on the Structure and Properties of Electrodeposited Ni-W-P Alloys

Amorphous and nanocrystalline Ni-W-P alloy films have been prepared by electrodeposition. The effect of sodium hypophosphite in the bath is important in determining the W and P contents of the alloy. The alloys prepared in the bath containing more than about 0.15 mol/L of sodium hypophosphite are only Ni-P alloys containing high P contents (>21% (at)) and no W at all. However, as the sodium hypophosphite content is decreased, the W content in the alloy increases and reaches about 20% (at) with decreasing P content to about 1% (at) at 6 x 10 -4 mol/L of sodium hypophosphite. The alloys containing high P contents are amorphous, while those containing high W contents have a nanocrystalline phase with apparent grain size of 2.3 nm at 20% (at) W content. These nanocrystalline alloys show high hardness values up to about 780 MVH.
Preschoolers' Counting and Sharing

Both counting and sharing require action on discrete elements, entailing the logic of one-to-one correspondence. How counting and sharing relate to one another was the focus of an experiment conducted to examine strategies preschool children used to subdivide items. We designed tasks in which applications of counting skills, of visual cues such as subitizing, and of informal measurement skills were made more difficult. Children exhibited alternative strategies, suggesting use of a recipient as a mental cycle marker and an adjacent recipient strategy, with pauses between allocations suggesting a re-presentation of lots corresponding to the number of recipients. Results supported the view that dealing competence does not relate directly to counting skill. Mathematics, to the adult mind, is inseparably tied to notation and symbolism. As a result, children are generally given little credit for mathematical understanding before they begin school, although the process of constructing mathematical knowledge begins well before this time. Research by Rea and Reys (1970), Hendrickson (1979), Hughes (1986), Bergeron and Herscovics (1990), Young-Loveridge (1987), and Kamii (1985) has shown that young children have an impressive range of numerical skills at the onset of schooling. The Curriculum and Evaluation Standards for School Mathematics (National Council of Teachers of Mathematics [NCTM], 1989) stated that “children enter kindergarten with considerable mathematical experience, a partial understanding of many concepts, and some important skills, including counting” (p. 16). Not only do young children come to school with a wealth of informal mathematical concepts and variable skills and abilities, there is evidence that their understanding of conceptual aspects of mathematics may not be manifest in their efforts to communicate using conventional symbolism. Carraher and Schliemann (1990) found that some children, with no previous school instruction on the numeration system, had a good understanding of conceptual aspects of the numeration system despite an inability to generate the number-name sequence systematically. Most early mathematics learning is concerned with developing whole number knowledge, especially counting. Children from an early age spontaneously practice counting skills, including the conventional number-name sequence. The cognitive skills of both counting and sharing seem to develop during the early childhood years. Both skills require action on discrete elements, entailing the logic of one-to-one cor
Isotopic Ratio Mass Spectrometry Study for Differentiation Between Natural and Adulterated Essential Oils of Lemongrass (Cymbopogon flexuosus) and Palmarosa (Cymbopogon martinii)

Abstract: Adulteration in aromatic oils with natural isolates and identical synthetic compounds is common practice in flavour and fragrance industry. Blending of synthetic materials is done in such a way that the chemical profile by gas chromatography of product (adulterated) oil remains nearly identical to original one. This practice makes complex issue for detection of adulterants in aromatic oil. In the present study, natural and adulterated essential oils of lemongrass (Cymbopogon flexuosus) and palmarosa (Cymbopogon martinii) were differentiated and identified on the basis of their carbon isotope composition (13C/12C) using isotopic-ratio mass spectrometry (IRMS) technique. This technique differentiates the natural oils (lemongrass and palmarosa oils) with adulterated oils by showing decrease in their carbon isotopic composition as blending of synthetic compounds viz. geraniol, citral, polyethylene glycol (PEG), dioctyl phthalate (DOP) and diethyl phthalate (DEP) of these adulterants with increasing order (5 % to 50 %).
Global warming impacts on Brazilian agriculture: estimates of the Ricardian model

This paper estimates the impact of climate change on agriculture in Brazil using the Ricardian approach. Our findings indicate that the net impact of climate change on Brazilian agriculture is negative, although there are varying regional consequences. March and September temperature and precipitation effects are positive, but are outweighed by the'more negative December and June effects. The Center-West region is most negatively affected, whereas the South benefits mildly from warming.
p38γ Activation and BGP (Biliary Glycoprotein) Induction in Primates at Risk for Inflammatory Bowel Disease and Colorectal Cancer—A Comparative Study with Humans

Colorectal cancer (CRC) is a common cause of cancer-related deaths largely due to CRC liver metastasis (CRLM). Identification of targetable mechanisms continues and includes investigations into the role of inflammatory pathways. Of interest, MAPK is aberrantly expressed in CRC patients, yet the activation status is not defined. The present study assessed p38γ activation in CRC patients, cancer cells, and tissues of cotton top tamarin (CTT) and common marmoset (CM). The primate world is an overlooked resource as colitis-CRC-prone CTT are usually inure to liver metastasis while CM develop colitis but not CRC. The results demonstrate that p38γ protein and phosphorylation levels are significantly increased in CRC patients compared to normal subjects and CTT. Furthermore, p38γ phosphorylation is significantly elevated in human CRC cells and hepatoblastoma cells but not in CM colon. Additionally, carcinoembryonic antigen (CEA) and biliary glycoprotein (BGP) are induced in the CRC patients that showed p38γ phosphorylation. Inhibition of p38 MAPK in CRC cells showed a significant decline in cell growth with no effect on apoptosis or BGP level. Overall, p38γ is activated in CRC tumorigenesis and likely involves CEA antigens during CRLM in humans but not in the CTT or CM, that rarely develop CRLM.
The First Case of L. pseudomesenteroides Pulmonary Infection and Literature Review

L. pseudomesenteroides is a very rare bacterium that infects human beings, and it has been used as an industrial fermentation bacterium. At present, only a few cases have been reported about this bacterium infecting the human body, but most reports are mainly about sepsis. We will report on a woman with lymphoma who was successfully diagnosed by the use of transbronchial cryobiopsy (TBCB) with L. pseudomesenteroides pulmonary infection.
A Modified Phase Cycling Method for Complex-Valued MRI Reconstruction

The phase cycling method is a state-of-the-art method to reconstruct complex-valued MR image. However, when it follows practical two-dimensional (2D) subsampling Cartesian acquisition which is only enforcing random sampling in the phase-encoding direction, a number of artifacts in magnitude appear. A modified approach is proposed to remove these artifacts under practical MRI subsampling, by adding one-dimensional total variation (TV) regularization into the phase cycling method to “pre-process” the magnitude component before its update. Furthermore, an operation used in SFISTA is employed to update the magnitude and phase images for better solutions. The results of the experiments show the ability of the proposed method to eliminate the ring artifacts and improve the magnitude reconstruction.
Theoretical Studies of the Possible Origin of Intrinsic Static Bends in Double Helical DNA

The macroscopic curvature induced in the double helical B-DNA by regularly repeated adenine tracts (A-tracts) is a long-known, but still unexplained, phenomenon. This effect plays a key role in DNA studies because it is unique in the amount and the variety of the available experimental information and, therefore, is likely to serve as a gate to unknown general mechanisms of recognition and regulation of genome sequences. In this paper, conformations of a 25-mer A-tract repeat have been studied by molecular dynamics simulations. It is shown that properly directed static curvature emerges spontaneously in independent MD trajectories starting from straight canonical A- and B-DNA forms. Dynamics converge to the same bent state in conditions excluding any initial bias except the base pair sequence. The ensemble of curved conformations, however, appears microscopically heterogeneous, in contradiction to all existing theoretical models of bending. Analysis of these unexpected observations leads to a new, signifi.
Immunometabolism, Micronutrients, and Bariatric Surgery: The Use of Transcriptomics and Microbiota-Targeted Therapies

Background Obesity is associated with the gut microbiota and decreased micronutrient status. Bariatric surgery is a recommended therapy for obesity. It can positively affect the composition of the gut bacteria but also disrupt absorption of nutrients. Low levels of micronutrients can affect metabolic processes, like glycolysis, TCA cycle, and oxidative phosphorylation, that are associated with the immune system also known as immunometabolism. Methods MEDLINE, PUBMED, and Google Scholar were searched. Articles involving gut microbiome, micronutrient deficiency, gut-targeted therapies, transcriptome analysis, micronutrient supplementation, and bariatric surgery were included. Results Studies show that micronutrients play a pivotal role in the intestinal immune system and regulating immunometabolism. Research demonstrates that gut-targeting therapies may improve the microbiome health for bariatric surgery populations. There is limited research that examines the role of micronutrients in modulating the gut microbiota among the bariatric surgery population. Conclusions Investigations are needed to understand the influence that micronutrient deficiencies have on the gut, particularly immunometabolism. Nutritional transcriptomics shows great potential in providing this type of analysis to develop gut-modulating therapies as well as more personalized nutrition recommendations for bariatric surgery patients.
Effects of whole-body vibrations on neuromuscular fatigue: a study with sets of different durations

Background Whole body vibrations have been used as an exercise modality or as a tool to study neuromuscular integration. There is increasing evidence that longer WBV exposures (up to 10 minutes) induce an acute impairment in neuromuscular function. However, the magnitude and origin of WBV induced fatigue is poorly understood. Purpose The study aimed to investigate the magnitude and origin of neuromuscular fatigue induced by half-squat long-exposure whole-body vibration intervention (WBV) with sets of different duration and compare it to non-vibration (SHAM) conditions. Methods Ten young, recreationally trained adults participated in six fatiguing trials, each consisting of maintaining a squatting position for several sets of the duration of 30, 60 or 180 seconds. The static squatting was superimposed with vibrations (WBV30, WBV60, WBV180) or without vibrations (SHAM30, SHAM60, SHAM180) for a total exercise exposure of 9-minutes in each trial. Maximum voluntary contraction (MVC), level of voluntary activation (%VA), low- (T20) and high-frequency (T100) doublets, low-to-high-frequency fatigue ratio (T20/100) and single twitch peak torque (TWPT) were assessed before, immediately after, then 15 and 30 minutes after each fatiguing protocol. Result Inferential statistics using RM ANOVA and post hoc tests revealed statistically significant declines from baseline values in MVC, T20, T100, T20/100 and TWPT in all trials, but not in %VA. No significant differences were found between WBV and SHAM conditions. Conclusion Our findings suggest that the origin of fatigue induced by WBV is not significantly different compared to control conditions without vibrations. The lack of significant differences in %VA and the significant decline in other assessed parameters suggest that fatiguing protocols used in this study induced peripheral fatigue of a similar magnitude in all trials.
The impact of psychological aspects, age, and BMI on eating disorder psychopathology among adult males and females with type 1 diabetes

This study investigated correlates of eating disorder (ED) psychopathology among adults with type 1 diabetes (T1D). A total of 282 males (n = 112) and females (n = 170) with T1D (18–79 years) participated. Overall, psychological aspects (i.e. illness perceptions, coping strategies, insulin beliefs, anxiety, and depression) were associated with ED psychopathology. Associations were generally stronger among females than males. In a regression model, age, BMI, personal control, and anxiety explained 51% of the variance in ED psychopathology among females, whereas BMI, personal control, and anxiety explained 47% of the variance among males. Greater clinical awareness of health psychological aspects may contribute to reduce the risk of developing ED.
Exposure to low concentrations of pesticide stimulates ecological functioning in the dung beetle Onthophagus nuchicornis

Body-size is an important trait for predicting how species contribute to ecosystem functions and respond to environmental stress. Using the dung beetle Onthophagus nuchicornis (Coleoptera: Scarabaeidae), we explored how variation in body-size affected ecosystem functioning (dung burial) and sensitivity to an environmental stressor (exposure to the veterinary anthelmintic ivermectin). We found that large beetles buried nearly 1.5-fold more dung than small beetles, but that mortality from exposure to a range of concentrations of ivermectin did not differ between large and small beetles. Unexpectedly, we found that exposure to low concentrations of ivermectin (0.01⁠–1 mg ivermectin per kg dung) stimulated dung burial in both small and large beetles. Our results provide evidence of ecological functioning hormesis stemming from exposure to low amounts of a chemical stressor that causes mortality at high doses.
Sensation of the tiniest kind: the antennal sensilla of the smallest free-living insect Scydosella musawasensis (Coleoptera: Ptiliidae)

Miniaturization is a major evolutionary trend prominent in insects, which has resulted in the existence of insects comparable in size to some unicellular protists. The adaptation of the complex antennal multisensory systems to extreme miniaturization is a fascinating problem, which remains almost unexplored. We studied the antennal sensilla of Scydosella musawasensis Hall, 1999 (Coleoptera: Ptiliidae), the smallest free-living insect, using scanning electron microscopy. The antenna of S. musawasensis bears 131 sensilla; no intraspecific variation in the number or position of the sensilla has been revealed. Nine different morphological types of sensilla are described according to their external morphological features and distribution: four types of sensilla trichodea, one type of sensilla chaetica, two types of sensilla styloconica, and two types of sensilla basiconica. Morphometric analysis of the sensilla of S. musawasensis, based on measurements of the lengths and diameters of sensilla and their location and number, showed the absence of significant differences between females and males. Comparative allometric analysis of S. musawasensis and larger Coleoptera showed that the number of sensilla and the size of sensilla chaetica decrease with decreasing body size. However, the number of the types of sensilla and the length and diameter of the multiporous sensilla basiconica revealed no correlation with the body size. Comparison of the acquired data with the results of our earlier study of the antennal sensilla of some of the smallest parasitic wasps is used to put forward hypotheses on the common principles of miniaturization of the antennal sensory systems of insects.
In Vitro Cytotoxic Activity against Breast, Cervical, and Ovarian Cancer Cells and Flavonoid Content of Plant Ingredients Used in a Selected Thai Traditional Cancer Remedy: Correlation and Hierarchical Cluster Analysis

This study aimed to investigate in vitro cytotoxic activity of selected plant ingredients from a traditional Thai remedy for the treatment of cancer patients against cancer cells occurring in women such as MCF-7 (breast cancer), SKOV3 (ovarian cancer), and HeLa (cervical cancer) cell lines. The plants and the remedy were macerated with 95% ethanol and boiled in water. Cytotoxic activity of the extracts was analyzed by SRB assay. Total flavonoid contents of the extracts were determined and their correlation with cytotoxic activity was evaluated. The hierarchical cluster analysis (HCA) was used to classify the extracts by their cytotoxic characteristics. A total of 66.7% of the plants was active against the tested cancer cell lines. Among the 44 plants in the remedy used for cancer treatment, nine plants that are also used in Thai cuisine exerted significant cytotoxicity against tested cancer cell lines. Eleven plants in the remedy were active against at least one of the tested cancer cell lines. All extracts were grouped into three groups and illustrated as heat map and hierarchical dendrogram. Total flavonoid content showed weak or no correlation with cytotoxic activity. A. dahurica, F. albopurpurea, and T. indica selectively exerted potent cytotoxic activity against MCF-7 with SI value more than 6. A. galanga, P. amarus, L. striatum, H. indicum, and F. vulgare exerted moderate cytotoxicity to all tested cell with low toxicity to normal cells. The correlation and HCA performed in this study provided an alternative way to investigate biological activities of plant ingredients in polyherbal traditional remedies.
TET2 rs1548483 SNP Associating with Susceptibility to Molecularly Annotated Polycythemia Vera and Primary Myelofibrosis

Background: The complexity of myeloproliferative neoplasms (MPNs) cannot be characterized by acquired somatic mutations alone. Individual genetic background is thought to contribute to the development of MPNs. The aim of our study was to assess the association between the TET2 rs1548483 single nucleotide polymorphism (SNP) and the susceptibility to polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF) or chronic myeloid leukemia (CML). Methods: We evaluated the TET2 rs1548483 SNP through real-time PCR in 1601 MPN patients out of which 431 with PV, 688 with TE, 233 with PMF, 249 with CML and 197 controls. We included only patients with a molecularly proven driver mutation, such as JAK2 V617F, CALR or BCR-ABL1. Results: Significant association between TET2 rs154843 variant allele and JAK2 V617F-positive PV and PMF (OR = 1.70; 95% CI: 1.01–2.91; p-value = 0.046, and OR = 2.04; 95% CI: 1.10–3.77; p-value = 0.024, respectively), and type 2 CALR-positive PMF (OR = 2.98; 95% CI: 1.12–7.93; p-value = 0.035) was noted. Conclusions: The TET2 rs1548483 SNP is associated with the susceptibility to molecularly annotated PV and PMF.
Study on Medication Rules of Traditional Chinese Medicine against Antineoplastic Drug-Induced Cardiotoxicity Based on Network Pharmacology and Data Mining

Methods The targets of antineoplastic drugs with cardiotoxicity were obtained from the National Center for Biotechnology Information (NCBI) database, China national knowledge infrastructure (CNKI) database, and Swiss Target Prediction platform. Then, the cardiotoxicity-related targets were derived from the Gene Cards, Disgenet, OMIM, and DrugBank databases, as well as the drug of current clinical guidelines. The targets both in these two sets were regarded as potential targets to alleviate ADIC. Then, candidate compounds and herbs were matched via Traditional Chinese Medicine Systems Pharmacology (TCMSP) platform. Cytoscape3.7. 1 was used to set up the target-compound-herb network. Molecular docking between core targets and compounds was performed with AutodockVina1.1. 2. The rules of herbs were summarized by analyzing their property, flavor, and channel tropism. Results Twenty-one potential targets, 332 candidate compounds, and 400 kinds of herbs were obtained. Five core targets including potassium voltage-gated channel subfamily H member 2 (KCNH2), cyclin-dependent kinase 1 (CDK1), matrix metalloproteinase 2 (MMP2), mitogen-activated protein kinase1 (MAPK1), and tumor protein p53 (TP53) and 29 core compounds (beta-sitosterol, quercetin, kaempferol, etc.) were collected. Five core herbs (Yanhusuo, Gouteng, Huangbai, Lianqiao, and Gancao) were identified. Also, the TCM against ADIC were mainly bitter and acrid in taste, warm in property, and distributed to the liver and lung meridians. Conclusion TCM against ADIC has great potential. Our study provides a new method and ideas for clinical applications of integrated Chinese and western medicine in treating ADIC.