Miracle-dz/UniFAR-FTUs huggingface dataset:
Potential role of Rab4 in the regulation of subcellular localization of Glut4 in adipocytes

A role for Rab4 in the translocation of the glucose transporter Glut4 induced by insulin has been recently proposed. To study more directly the role of this small GTPase, freshly isolated adipocytes were transiently transfected with the cDNAs of both an epitope-tagged Glut4-myc and Rab4, a system which allows direct measurement of the concentration of Glut4 molecules at the cell surface. When cells were cotransfected with Glut4-myc and Rab4, the concentration of Glut4-myc at the cell surface decreased in parallel with the increased expression of Rab4, suggesting that Rab4 participates in the intracellular retention of Glut4. In parallel, the amount of Rab4 associated with the Glut4-containing vesicles increased. When Rab4 was moderately overexpressed, the number of Glut4-myc molecules recruited to the cell surface in response to insulin was similar to that observed in mock-transfected cells, and thus the insulin efficiency was increased. When Rab4 was expressed at a higher level, the amount of Glut4-myc present at the cell surface in response to insulin decreased. Since the overexpressed protein was predominantly cytosolic, this suggests that the cytosolic Rab4 might complex some factor(s) necessary for insulin action. This hypothesis was strengthened by the fact that Rab4 deltaCT, a Rab4 mutant lacking the geranylgeranylation sites, inhibited insulin-induced recruitement of Glut4-myc to the cell surface, even when moderately overexpressed. Rab3D was without effect on Glut4-myc subcellular distribution in basal or insulin-stimulated conditions. While two mutated proteins unable to bind GTP did not decrease the number of Glut4-myc molecules in basal or insulin-stimulated conditions at the plasma membrane, the behavior of a mutated Rab4 protein without GTPase activity was similar to that of the wild-type Rab4 protein, indicating that GTP binding but not its hydrolysis was required for the observed effects. Altogether, our results suggest that Rab4, but not Rab3D, participates in the molecular mechanism involved in the subcellular distribution of the Glut4 molecules both in basal and in insulin-stimulated conditions in adipocytes.
D-face: Parallel Implementation of CNN Based Face Classifier using Drone Data On K40 & Jetson TK1

Deep Convolutional Neural Networks(CNNs) are shown to perform very well in the areas such as video surveillance, object classification and face classification. Face classification has become pertinent to numerous applications, especially in this big data era of social platforms and social media. With the usage of unmanned air-borne vehicles like drones, the problem of face classification becomes very challenging because of the large visual variations. In this paper we introduce D-face, a novel application for face classification, and the input to the classification model is taken from the drone video sequences. In recent times, the CNNs have gained a significant importance in the class of classification problems, but the cons being its computational intensity. High performance computing using Graphical Processing Units(GPUs) has become an important tool in solving the compute intensive problems. We have used GPUs to speedup the classification rate for our problem. We bring about a faster parallel implementation that achieves almost 13x on GPUs compared to its serial implementation. Keywords-Face classification, Convolutional neural networks, GPU
Digital predistortion of a power amplifier for signals comprising widely spaced carriers

Digital predistortion (DPD) of a RF power amplifier (PA) for signals comprising two widely spaced carrier clusters is proposed. The basis waveforms within the DPD are selected to allow for the use of a lower sampling rate. Multi-carrier signals spanning 60 MHz of bandwidth are linearized using a sample rate of 100 MHz for the transmitter and observation paths, as oppose to a sample rate exceeding 300 MHz (5 times Nyquist) used conventionally. A transmit (Tx) filter located after the PA attenuates intermodulation distortion (IMD) falling outside of the 100 MHz of correction bandwidth provided by the DPD.
Design Challenges in Silicon Photonics

Silicon photonics is rapidly gaining maturity in high-bandwidth optical communication, with applications in datacom, access networks, and I/O for bandwidth-intensive electronics. Also, applications are emerging in spectroscopy and sensing. To get the best performance out of the photonics, co-integration with electronics is needed: side-by-side, stacked, or on the same chip. However, the combination of photonics and electronics introduces a range of new problems on the design side: Codesign and cosimulation of complex photonic and electronic circuits, tolerance to variability, and verification algorithms that can handle photonic circuits. We will discuss these challenges and give an outlook on how tools need to evolve to address the needs of photonic-electronic IC designers.
High‐Moment Antiferromagnetic Nanoparticles with Tunable Magnetic Properties

Chemically synthesized superparamagnetic nanoparticles are widely used in biology and medicine for applications that include biomolecule purifications and cell separations, magnetic resonance imaging (MRI) contrast agents, and biomagnetic sensing. Magnetic nanoparticles with high moments are often desired to produce large signals for biomagnetic sensing or to avoid restrictive requirements for high magnetic field gradients in separations. Increasing the size of single-grain superparamagnetic particles is not a viable route because these particles become coercive and, consequently, spontaneously aggregate at sizes above the superparamagnetic limit (ca. 12 nm for Fe). One solution is to incorporate numerous magnetic nanoparticles into larger composites using matrices comprised of dextran or silica. However, there are still limitations associated with controlling the monodispersity, magnetic response, and variations in the number and size of the embedded nanoparticles. Here we report the fabrication of strongly magnetic, zeroremanence, monodisperse nanoparticles with tailorable mag-
Exploring experiences of “participation” among individuals living with chronic pain

The aim of this paper is to advance our understanding of participation and its relation to occupation, by analysing the daily occupational experiences of six men and women living with chronic pain. Open-ended interviews are used in conjunction with a constant comparative method of analysis. The findings are thematically presented as: “taking initiative and making choices”, doing something physical”, “doing something social”, and “doing something for others”. Furthermore, a short vignette is presented in which the authors attempt to juxtapose theoretical constructs with individual experiences in order to illustrate another level of contextual richness of the data. Methodological implications are discussed in relation to the findings, analytic presentation, and previous research.
Monitoring social relationship among Twitter users by using NodeXL

Recently, various studies have been studying for measuring social relationship among online users by using social network service and expressing relationship through network. However, these previous researches did not consider the current time or generate relationships among the users, so they cannot clearly express the real time relationships among the users. In this study, to solve such problems, we collected the tweets of the Twitter and constructed a database by extracting user ID and hash tag based on MapReduce algorithm. By utilizing this, Twitter user relationship network map is designed and established, and this is compared and evaluated against Mentionmap network. As a result, the Twitter Network Map generated by the proposed method was more effective than the existing Mentionmap which used twitter OpenAPI.
High prevalence of reduced fecundity in men with congenital adrenal hyperplasia.

CONTEXT Testicular adrenal rest tumors (TARTs) are regarded to contribute to the high prevalence of subfertility in males with congenital adrenal hyperplasia (CAH). OBJECTIVES Our objectives were to evaluate reduced fecundity and its possible causes in well-controlled adult males with CAH, and to investigate diagnostic tools for improved treatment monitoring with respect to fertility outcomes. DESIGN In a cross-sectional study at the Department of Endocrinology at the University Hospital München, Germany, 22 adult male CAH patients (15 salt wasting and seven simple virilizing, age 19-48 yr) were clinically assessed according to their hormonal control. We performed testicular ultrasound (22 of 22), magnetic resonance imaging (18 of 22), and a semen analysis (19 of 22) in the participants. RESULTS All patients had a pathological semen analysis. TART prevalence was 10 of 22 (eight salt wasting, two simple virilizing). Poor therapy control was present in five patients, and all five had TARTs. Of the other 17 well-controlled patients with normal or suppressed adrenal androgens and 17-hydroxyprogesterone levels, five presented with TARTs. There was a significant correlation between sperm concentration and functional testicular volume (r = 0.70; P = 0.002), TART volume (r = -0.70; P = 0.036), as well as inhibin B levels (r = 0.75; P < 0.0001), respectively. In several men, hormonal control parameters suggested hypogonadism, with glucocorticoid overtreatment as a relevant factor for poor semen quality. CONCLUSIONS Poor semen parameters are common in male CAH patients. TARTs, most likely reflecting undertreatment, as well as inhibin B are important indicators of fecundity. On the other hand, long-term glucocorticoid overtreatment also seems to contribute to low semen quality.
A Million Turnover Molecular Anode for Catalytic Water Oxidation.

Molecular ruthenium-based water oxidation catalyst precursors of general formula [Ru(tda)(Li )2 ] (tda2- is [2,2':6',2''-terpyridine]-6,6''-dicarboxylato; L1 =4-(pyren-1-yl)-N-(pyridin-4-ylmethyl)butanamide, 1 b; L2 =4-(pyren-1-yl)pyridine), 1 c), have been prepared and thoroughly characterized. Both complexes contain a pyrene group allowing ready and efficiently anchoring via π interactions on multi-walled carbon nanotubes (MWCNT). These hybrid solid state materials are exceptionally stable molecular water-oxidation anodes capable of carrying out more than a million turnover numbers (TNs) at pH 7 with an Eapp =1.45 V vs. NHE without any sign of degradation. XAS spectroscopy analysis before, during, and after catalysis together with electrochemical techniques allow their unprecedented oxidative ruggedness to be monitored and verified.
Air Quality Impacts of Distributed Energy Resources Implemented in the Northeastern United States

Abstract Emissions from the potential installation of distributed energy resources (DER) in the place of current utility-scale power generators have been introduced into an emissions inventory of the northeastern United States. A methodology for predicting future market penetration of DER that considers economics and emission factors was used to estimate the most likely implementation of DER. The methodology results in spatially and temporally resolved emission profiles of criteria pollutants that are subsequently introduced into a detailed atmospheric chemistry and transport model of the region. The DER technology determined by the methodology includes 62% reciprocating engines, 34% gas turbines, and 4% fuel cells and other emerging technologies. The introduction of DER leads to retirement of 2625 MW of existing power plants for which emissions are removed from the inventory. The air quality model predicts maximum differences in air pollutant concentrations that are located downwind from the central power plants that were removed from the domain. Maximum decreases in hourly peak ozone concentrations due to DER use are 10 ppb and are located over the state of New Jersey. Maximum decreases in 24-hr average fine particulate matter (PM2.5) concentrations reach 3 μg/m3 and are located off the coast of New Jersey and New York. The main contribution to decreased PM2.5 is the reduction of sulfate levels due to significant reductions in direct emissions of sulfur oxides (SOx) from the DER compared with the central power plants removed. The scenario presented here represents an accelerated DER penetration case with aggressive emission reductions due to removal of highly emitting power plants. Such scenario provides an upper bound for air quality benefits of DER implementation scenarios.
Absorption across the Thick Ascending Limb Is Not Altered in Cystic Fibrosis Mice A Role for a Pseudo-CFTR Cl 2 Channel

The cortical thick ascending limb (CTAL) absorbs Cl 2 via a Na 1 -K 1 -Cl 2 cotransport at the apical membrane and several Cl 2 channels at the basolateral membrane, including a 9-pS channel having several properties of the cystic fibrosis transmembrane conductance regulator (CFTR). Having checked that CFTR mRNA is present in the mouse CTAL, we investigated whether this channel is a CFTR molecule by applying the patch-clamp technique to CTALs microdissected from CFTR knockout mice ( cftr m1Unc ). The 9-pS channel was active in cell-attached patches from tubules of mice homozygous for the disrupted cftr gene [CFTR ( 2 / 2 )] at the same frequency and with the same activity ( NP o ) as in normal [CFTR ( 1 / 1 )] or heterozygous [CFTR ( 1 / 2 )] mice. The conductive properties of the channel, studied on inside-out patches, were identical in CFTR ( 2 / 2 ), CFTR ( 1 / 1 ), and CFTR ( 1 / 2 ) tubules, as were the sensitivities to internal pH and internal ATP, two typical features of this channel. In addition, the Cl 2 absorption in isolated, microperfused CTALs and the Na 1 -K 1 -Cl 2 cotransport activity were identical in CFTR ( 2 / 2 ), CFTR ( 1 / 1 ), and CFTR ( 1 / 2 ) mice. These results show that the 9-pS Cl 2 channel is distinct from CFTR, and that the CFTR protein has no influence on the Cl 2 absorption in this part of the renal tubule. ( J. Clin. Invest. 1998. 102:1986–1993.)
Colonoscopy Under General Anesthesia in Children

Objective. In children, colonoscopy is usually performed using deep sedation that may be associated with significant risks. The purpose of this study was to evaluate the safety of colonoscopy performed under general anesthesia. Methods. All patients undergoing colonoscopy during a 3-year period were reviewed for the study. One hundred and thirty-six procedures were performed. Colonoscopies were performed by a pediatric gastroenterologist. Anesthesia was administered by a pediatric anesthetist in a gastroenterology procedure room, adjacent to the operating recovery area. Results. Three patients had significant abdominal pain and tenderness after the procedure, 1 of whom suffered a perforation of the sigmoid colon. This patient had severe ulcerative colitis. The gastrointestinal complication rate was no higher than reported in adult patients undergoing colonoscopy under sedation. No significant complications relating to the administration of anesthesia were encountered. Conclusion. We conclude that colonoscopy performed under general anesthesia in children is a very safe procedure. It is superior to the use of sedation because the child is not placed at risk of respiratory compromise. Furthermore, the procedure is less worrisome for children when performed under a general anesthetic.
Robust Extended Kalman filter for ballistic object tracking during re-entry

In this paper a robust Extended Kalman filter (EKF) for state estimation of a ballistic object with nonlinear dynamics is proposed. Outliers in the measurement can seriously degrade the estimation performance of conventional nonlinear filters. The proposed robust filter resists the effect of outliers to provide improved estimation. The square of Mahalanobis distance of innovation vector is taken as the judging index for robustness. Then the proposed robust algorithm has been evaluated with a benchmark problem of ballistic object tracking during re-entry phase. With the help of simulation, it is shown that when measurement outliers exist, the robust algorithm outperforms its conventional versions.
A Bidirectional Readout Integrated Circuit (ROIC) with Capacitance-to-Time Conversion Operation for High Performance Capacitive MEMS Accelerometers

In this paper, a bidirectional readout integrated circuit (ROIC) with capacitance-to-time conversion operation has been proposed and demonstrated for high performance capacitive micro-electro-mechanical system (MEMS) accelerometers, which is implemented by a 0.35-mum CMOS EEPROM process. For the desired performance of the proposed ROIC, a bidirectional time-to-digital conversion (TDC) method with a capacitance-to-time (C-T) conversion operation is employed for the detection of the directions. At the condition of the reference capacitance (CRef.) of 20 pF, the new ROIC shows the positive sign-bit ('1') for the case of the sensor capacitance (CSen.) < 20 pF and the negative sign-bit ('0') for the case of CSen. > 20 pF, which lead to the bidirectional accelerometer operation. Consequently, the new proposed ROIC exhibits the bidirectional readout operation by the bidirectional TDC operation with the C-T conversion.
Researcher Knows Best?

Missing from recent critiques of coping measurement are data demonstrating whether concepts used by researchers are understood by study participants. We asked 101 rheumatoid arthritis patients to complete a structured coping checklist and provide descriptions of their coping for each item checked. Trained researchers coded these open-ended descriptions using the original checklist categories. In general, patients' descriptions of their coping matched researcherderived definitions; however, patients were less likely to interpret cognitive and affective coping strategies in the manner intended by researchers. Patients' descriptions often crossed multiple categories, suggesting complex patterns not captured by most data analytic techniques. Whether they assess coping through structured measures or not, researchers must find ways to examine the multiple meanings and combinations of strategies that constitute the coping process. Keywords
New Developments in the Field: Measuring Community Climate

Community climate is the degree of support for GLBT people within a specific locale. In this paper we describe the elements of community climate, theorize how it is produced, and argue that this approach provides an important elaboration of Meyer's (2003) minority stress model. Furthermore, we present a new methodology for assessing community climate that could be used by any researcher with a geographically diverse data set that includes location identifiers such as ZIP code. In closing we discuss the theoretical, empirical, and practical contributions that could be made by GLBT family scholars who utilize this new technique for measuring community climate.
A data management system for identifying the traceability of returnable transit items using radio frequency identification portals

The advancement of paradigms such as Industry 4.0 and cyber physical systems herald increased productivity and efficiency for manufacturing businesses through increased capture and communication of data, information and knowledge. However, interpreting the raw data captured by sensing devices into useful information for decision making can be challenging as it often contains errors and uncertainty. This paper specifically investigates the challenges of analysing and interpreting data recorded using Radio Frequency IDentification (RFID) portals to monitor the movements of Returnable Transit Items (RTI), such as racks and stillage, within an automotive manufacturing environment. Data was collected over a yearlong pilot study using an RFID portal system installed across two automotive facilities to trace the movement of RTIs between the sites. Based upon the results key sources of errors and uncertainty have been identified and a data management framework is proposed to alleviate these errors.
Stabilization of Grid Connected Wind Generator by STATCOM

Recently voltage-source or current-source inverter based various FACTS devices have been used for flexible power flow control, secure loading and damping of power system oscillation. Some of those are used also to improve transient and dynamic stability of wind power generation system (WPGS). In this paper, we propose the static reactive compensator (STATCOM) based on voltage source converter (VSC) PWM technique to stabilize grid connected squirrel cage wind generator system. A simple control strategy of STATCOM is adopted where only measurement of rms voltage at the wind generator terminal is needed, i.e. there is no need of reactive power measurement. Fuzzy logic controller is used as the control methodology of STATCOM, rather than conventional PI controller. The voltage sag and swell improvement of WPGS is compared with both fuzzy and PI controller. Moreover, the steady state capacitor value used with induction generator is reduced by certain percentage when STATCOM is used with WPGS. Comprehensive results are presented to assess the performance of the STATCOM connected with WPGS, where the simulations have been done by PSCAD/EMTDC.
Maternal caffeine consumption and risk of congenital limb deficiencies.

BACKGROUND Animal studies have shown that high doses of caffeine might cause congenital limb deficiencies (LDs); however, no epidemiologic studies have explored this relation. METHODS This case-control study assessed associations between maternal dietary caffeine and congenital LDs using data from the National Birth Defects Prevention Study (NBDPS), with 844 LD cases and 8069 controls from 1997 to 2007. Caffeine intakes from beverages (coffee, tea, and soda) and chocolate combined and by beverage type were examined. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated for subtypes of isolated LDs (no additional major anomalies) and LDs with other major anomalies separately, comparing the odds of 10 to <100, 100 to <200, 200 to <300, and 300+ mg/day total caffeine intake to 0 to <10 mg/day. RESULTS All total dietary caffeine intake categories of 10 mg/day and above were marginally associated with odds of all isolated LDs combined (aOR, 1.4-1.7), isolated longitudinal LDs (aOR, 1.2-1.6), and isolated transverse LDs (aOR, 1.3-1.8) compared to the lowest intake category. A dose-response pattern for total dietary caffeine intake was not observed. CONCLUSIONS A weak increased risk of congenital LDs associated with maternal dietary caffeine consumption was observed in this study; however, risk did not vary by amount of caffeine consumed.
Short term forecasting of stock market based on R/S analysis and fuzzy neural networks

Input space of nonlinear model is partitioned into several fuzzy subspaces. Within each subspace, a local linear model is used to model the local features of nonlinear system, and then the global model output is obtained by interpolating the outputs of local models. Adaptive network fuzzy inference system, based on Sugeno fuzzy inference model, is one way of neural network realization of the fuzzy modeling based on the idea of local linear modeling above. The results of R/S analysis show that Shanghai stock market has long-term memory, thus possible to predict. This paper combines adaptive network fuzzy inference system and fractal market hypothesis to implement multi-step prediction of Shanghai Stock Composite Index. The final result shows that the prediction can benefit from human's intuitive knowledge on the market, even if it is little and simple.