Miracle-dz/UniFAR-FTUs huggingface dataset:
Status epilepticus in mitochondrial diseases and the role of POLG1 variants in the valproic-acid induced hepatotoxicity

Various genetic aetiologies – including mitochondrial diseases, chromosomal disorders, and other monogenic diseases – are involved in status epilepticus (SE), a common neurologic emergency occurring in children and adults that exhibits high rates of morbidity and mortality. The exact frequency of mitochondrial SE is currently undefined. Furthermore, patients with pathogenic variants of POLG1 encoding mitochondrial DNA polymerase gamma have an increased risk of acute liver failure (ALF) induced by the common antiepileptic drug, valproic acid (VPA), which is problematic due to these patients also often experiencing drug-resistant seizures. Overall, the role of liver transplantation (LT) in VPA-ALF due to mitochondrial disease has been controversial. In the present work, large retrospective cohort studies were conducted for two main purposes: (1) to determine the genetic aetiologies of SE among Finnish paediatric and adult patients by specifically focusing on the common mitochondrial genetic defects associated with an increased risk of SE and (2) to examine whether common POLG1 p.Q1236H and p.E1143G variants are connected to liver or pancreatic toxicity upon exposure to VPA monotherapy. This thesis also describes the characteristics of VPA-ALF associated with the pathogenic POLG1 variant p.W748S and the prognosis of LT in a retrospective case series. Mitochondrial diseases explained 4.5% of SE cases in the study cohort. Patients with mitochondrial SE suffered from refractory SE significantly more often than patients with other forms of genetic or non-genetic SE. Additionally, mortality rates were higher in patients with mitochondrial or chromosomal disorders compared with the other groups, reflecting the severity of the underlying condition and the higher frequency of refractory SE. POLG1 variants p.Q1236H and p.E1143G could not be identified as risk factors for VHT or pancreatic toxicity, implying that VPA treatment might be suitable for patients harbouring these variants when other pathogenic variants are absent. Finally, the homozygous status of the pathogenic POLG1 variant p.W748S and older age of the patient during the presentation of VPA-ALF seem to be associated with higher survival rates following LT, which should be considered in the management of VPA-ALF.
Exploring the Complexity of Location Choices of the Creative Class in Europe: Evidence from the EU Labor Force Survey 1995–2010

This paper proposes a new idea for the current argument over Florida’s cultural policies, as location choices of the creative class is a complex process involving some basic aspects of socio-economic progress. Based on the European Labor Force Survey (EU LFE) dataset, tolerance and openness indicators which represent the quality of a “people climate” are found to be positively correlated with the creative class’s location in large regions and less so in smaller ones, where business climate-related parameters, i.e., the quality of local governments and the location of universities, have stronger positive effects on locational choices of the creative class. Moreover, graduates with non-creative jobs and creative professionals (i.e., workers who provide creative solutions during the work process such as high-tech technicians or legal and healthcare workers) are concerned more about the people climate, while creative workers with a degree and a creative core (e.g., workers who provide original ideas such as scientists, engineers and artists) are more likely to prioritize a business climate. Therefore, we argue that the promotion of a “tolerant” climate, as Florida advocates, is not a one-size-fits-all solution. Instead, policy makers should appropriately relate different preferences of creative workers to their unique strengths. This provides more insights into defining the concept of creativity beyond prioritized individual success, as well as understanding the preferences and actual needs of highly skilled workers in Europe.
Understanding the preferences of males at different ages for plaid shirts

Except the physiological comfort, the design aesthetic of plaid shirts is the decisive factor affecting the purchase decision making of consumers. However, as there is subjectivity and indeterminacy in evaluation of the aesthetic, current research in the literature has little information about the appearance design of checks. The purpose of this paper is to extract the check design features, which influence consumer evaluation, and determine the preferences of men of different ages for the check designs, and the preference differences between them. ,Through cluster and preference experiments, the perception and evaluation of the subjects were gained. By cluster analysis, typical classifications of check designs were fixed. With Multidimensional Scaling (MDS) algorithm, users’ perceptual space was revealed as to the plaid samples. In the PREFMAP analysis, results of the ideal vectors of men of different ages were drawn. ,The study results revealed four typical classifications of check designs, identified three design dimensions that had effects on users’ evaluation, and built the relationship between design features of checks and consumer evaluation. Besides, in the study, the differences in preference for check designs between men of different ages were also explored. It was found that young men liked modern check designs, but disliked “small and complex” check patterns. Middle aged men preferred dark and cool colors, with dislike for “youthful vigor style. ” While they cared more about check colors, young men attached more importance to the design style. ,Currently, there is little information in the literature about the evaluation of pattern design. In this study, the use of MDS and PREFMAP analysis reveals visualized complex statistical results. The visualization approach is also applicable to design and positioning of other apparel, and can help designers better understand and position design styles and effects, given their consumer groups and design samples.
Response to Reviewer #1

In May 2012, we conducted a hydrographic survey over the Carlsberg Ridge in the northwest Indian Ocean. In this paper, we use these station data, in combination with some free-floating Argo profiles, to obtain the sectional temperature and salinity fields, and subsequently, the hydrographic characteristics are comprehensively analyzed. Through the basic T-S diagram, three salty water masses, Arabian Sea High-Salinity Water, Persian Gulf Water, and Red Sea Water, are identified. The sectional data show a clear ventilation structure associated with Arabian Sea High-Salinity Water. The 35.8 psu salty water 5 sinks at 6.9N and extends southward to 4.4N at depths around the thermocline, where the thermocline depth is in the range of 100 to 150 m. This salty thermocline extends much further south than the climatology indicates. Furthermore, the temperature and salinity data are used to compute the absolute geostrophic current over the specific section, and the results show mesoscale eddy vertical structure different from some widely used oceanic reanalysis data. We also find a west-propagating planetary wave disturbance at 6N, and the related features are described in terms of phase speed, horizontal and vertical structures. 10
Phylogenetic Analysis and Time Divergence of Genus Musa spp. Using S16 Protein Genes (Rps16) Intron Chloroplast

Family Musaceae is divided into three genera, Musa, Musella, and Ensete. The genus Musa became the genus with the most species cultivated in the Southeast Asian region. While the genus Musella and Ensete are monospecific genera that can only be found in certain regions. Distribution of banana nomenclature until now is still a debate. The taxonomic system of bananas is still based on conventional methods, namely by marking the genome. But unfortunately the nomenclature system is not suitable to be applied in the Southeast Asian region. The systematic history of the genus Musa apparently still has many problems such as biogeography, the comparison of phylogenetic trees and their evolution. Therefore be approached through an m arka molecular phylogenetic alisis menggunakan g en protein S16 (Rps16) chloroplast introns with Bayesian inference method and divergence time estimates using the log-normal clock relaxed. The results show that the tree topology produced monophyletic lineage, in terms of the separation of the genus Musa from the Musella lasiocarpa and Ensete ventricosum Outgroups
Determinants of outcome of children with type 1 diabetes in the North West Region of Cameroon

Background: In sub-Saharan Africa the prognosis of children with type 1 diabetes is poor. Many are not diagnosed and those that are diagnosed have a reduced life expectancy (less than one year). This study set out to identify the factors that predict glucose control in children and adolescents with type 1 diabetes in the North West Region of Cameroon. Methods: A hospital based cross-sectional study involving 76 children/adolescents (41 girls and 35 boys, mean age of 15.1 ± 3.1 years) suffering from type 1 diabetes included in the “Changing Diabetes in Children” (CDiC) program and attending the clinics for children living with type 1 diabetes in the North West Region. Data on glycosylated haemoglobin (HbA1c) as well as clinical and biochemical parameters at diagnosis and during the study period were obtained from the hospital records of participants. A structured questionnaire was used to obtain information on socio-demographic characteristics and diabetes related practices from participants. Odds ratios (OR) were calculated using logistic regression to assess the association between determinants and good glucose control. Results: The study population had a mean HbA1c of 10.3 ± 2.9%. There was a significant decrease in the mean HbA1c from diagnosis (11.1%) to the study period (10.3%) (p = 0.011). Multivariate analysis indicated that having a mother as the primary caregiver (OR 0.02, 95% CI 0.002 – 0.189) and minimal/moderate caregiver involvement in insulin injection (OR 26.8, 95% CI 4.4 – 56.1) were independent predictors of glucose control. Conclusion: This study has demonstrated that having a mother as a primary caregiver is an important predictor of good glycaemic control among children with type 1 diabetes. It is currently unclear whether the direct involvement of the mother is important or whether “mother as a primary caregiver” is a strong indicator for a setting in which diabetes treatment is possible.
IMPROVEMENT OF THE ALGORITHMFOR THE CALCULATION OF THE AVERAGE WEIGHTED THERMAL POWER OF THE VVER-1000 CORE AND THE ESTIMATION OF ITS ERROR

Ю. О. Комаров, О. Л. Арванінов, А. А. Смичок Удосконалення алгоритму розрахунку середньозваженого значення теплової потужності активної зони ВВЕР-1000 і оцінка його похибки. Вимірювання теплової потужності активної зони реактора (АкЗ) на атомних електростанціях (АЕС) з водо-водяним енергетичним реактором електричною потужністю 1000 МВт (ВВЕР1000) можна характеризувати як непрямі, нерівноточні, незалежні. Представлено аналіз п'яти існуючих способів оцінки теплової потужності АкЗ. Показана існуюча проблема оцінки точності отримання середньозваженого значення теплової потужності (СЗТП) АкЗ. Оцінка значення СЗТП АкЗ є найкращою оцінкою з одержуваному ряду (з п'яти значень) теплової потужності АкЗ. При цьому оцінки вагового коефіцієнта кожного вимірювання пов'язані з оцінкою похибки даного виміру. Чим вище точність методу, тим вище вага даної оцінки. Представлено аналіз методики оцінки теплової потужності АкЗ, реалізований в програмній частині системи внутрішньореакторного контролю (СВРК) ВВЕР-1000. Показано, що для практичного використання для оцінки теплової потужності АкЗ на АЕС з ВВЕР-1000 облік всіх класів і видів похибки можливий коректної оцінкою двох складових випадкова і систематична похибка. При цьому облік обох складових похибки (випадкової і систематичної) є обов'язковим. Розроблено методику, яка враховує такі основні аспекти: по кожному прямому вимірюванню (тиск, температура, тощо) оцінюється як сама величина, так і її похибка; для кожного (з п'яти) способів вимірювання теплової потужності АкЗ на підставі функціональних залежностей і похибки прямих вимірювань проводиться оцінка похибки непрямого вимірювання даної теплової потужності; проводиться оцінка вагових коефіцієнтів кожного способу вимірювання за величиною похибки непрямого вимірювання теплової потужності АкЗ; оцінка абсолютної похибки середньозваженого значення потужності проводиться за методикою оцінки точності для непрямих вимірювань. В результаті, існуючий на АЕС алгоритм СВРК доповнено розрахунковими залежностями для оцінки похибки СЗТП АкЗ і розрахунками похибки всіх складових, необхідних для розрахунку СЗТП. Представлені шляхи модифікації існуючого в СВРК алгоритму і уточнення константної бази даних СВРК для підвищення точності оцінки СЗТП АкЗ. Ключові слова: теплова потужність, похибка, середньозважене значення, ВВЕР, СВРК
IMPLEMENTING PERCEPTUAL SEMANTICS IN TYPE THEORY WITH RECORDS (TTR)

Type Theory with Records (TTR) provides accounts of a wide range of semantic and linguistic phenomena in a single framework. This work proposes a TTR model of perception and language. Utilizing PyTTR, a Python implementation of TTR, the model is then implemented as an executable script. Over pure Python programming, TTR provides a transparent formal specification. The implementation is evaluated in a basic visual question answering (VQA) use case scenario. The results show that an implementation of a TTR model can account for multi-modal knowledge representation and work in a VQA setting.
Robust Observer-Based Load Extenuation Control for Wind Turbines

Wind energy is currently the fastest growing electricity source. To meet the output demand, wind turbines are becoming larger and more flexible leading to the problems of structural load especially in case of offshore turbines. Advanced control algorithms are developed to reduce the load, allowing to build larger turbines, and expand their lifetime. Observer-based control algorithms such as Linear-Quadratic-Gaussian LQG control which uses LQR to calculate the optimal observer and controller gains are commonly applied to wind turbines in literature. However the approach requires to calculate the observer and control gains separately. In addition, linear models used for parameter calculation may have errors with respect to the nonlinearities of wind turbines and induced to unmodeled dynamical properties. These modeling errors need to be considered to to guarantee the stability of the controlled system. Alternatively a robust design assuming bounds and limits of models have to be realized to guarantee stability while ignoring details of modeling. This paper proposes an optimal robust observer-based state feedback controller for large-scale wind turbines to realize multi objectives, including structural load mitigation and rotor speed regulation. The novel contribution is that the observer gain parameters, control gains, and integral action are optimized at the same time within H∞ mixed sensitivity framework to achieve desired performance with respect to power regulation, structural load mitigation, and also robustness for the wind turbine control system. The control performances have been verified by a high fidelity simulation software and are compared to those of a classical baseline controller.
A female perspective: testing the effects of noise masking on signal transmission patterns inside the nest box

During the breeding season, avian pairs coordinate interactions with songs and calls. For cavity nesting birds, females inside nest boxes may rely on male vocalizations for information. Anthropogenic noise masks male songs, which could affect information gained by females. We explored song transmission from a female house wren (Troglodytes aedon) perspective, testing the hypothesis that noise masking alters songs that reach females inside nest boxes. We broadcast songs at three distances up to 25 m from nest boxes and re-recorded songs using two microphones, positioned inside and outside nest boxes. We measured signal-to-noise ratios and cross-correlation factors to estimate the effects of masking on transmission. In noise, songs received inside nest boxes had lower signal-to-noise ratios and cross-correlation factors than songs recorded outside of boxes, and these effects decreased with distance. For females, noise may reduce information conveyed through male songs and in response pairs may need to adjust their interactions.
Clustering-Based Model Reduction of Laplacian Dynamics With Weakly Connected Topology

This article studies the structure-preserving model reduction of Laplacian dynamics, which represent weakly connected directed networks with diffusive couplings. The notion of clusterability is introduced to guarantee a bounded reduction error, and a clustering algorithm is then proposed to partition the nodes into clusters, such that the nodes in each cluster form a connected subgraph of the original network. Then, a reduced-order model, which is established using the generalized balanced form of the original network, preserves the weakly connection structure and consensus property. Finally, the effectiveness of the proposed approach is illustrated by a numerical example.
The use of menstruation and fertility app trackers: A scoping review of the evidence

Introduction: There has been a phenomenal worldwide increase in the development and use of mobile health applications (mHealth apps) that monitor menstruation and fertility. Critics argue that many of the apps are inaccurate and lack evidence from either clinical trials or user experience. The aim of this scoping review is to provide an overview of the research literature on mHealth apps that track menstruation and fertility. Method: This project followed the PRISMA Extension for Scoping Reviews. The ACM, CINAHL, Google Scholar, PubMed, and Scopus databases were searched for material published between 1 st January 2010 and 30 th April 2019. Data summary and synthesis were used to chart and analyse the data. Results: In total 654 records were reviewed. Subsequently, 135 duplicate records and 501 records that did not meet the inclusion criteria were removed. Eighteen (n=18) records from 13 countries form this review. The papers reviewed cover a variety of disciplinary and methodological frameworks. Three main themes were identified: fertility and reproductive health tracking; pregnancy planning; and, pregnancy prevention. Discussion & conclusions: Motivations for fertility app use are varied, overlap and change over time although women want apps that are accurate and evidence-based regardless of whether they are tracking their fertility, planning a pregnancy or using the app as a form of contraception. There is a lack of critical debate and engagement in the development, evaluation, usage, and regulation of fertility and menstruation apps. The paucity of evidence-based research and absence of fertility, health professionals and users in studies is raised.
Adult Reflection on Engaging Youth of Color in Research and Action: A Case Study From Five U.S. Cities

With the proliferation of participatory approaches to promoting youth development such as Youth-Led Participatory Action Research (YPAR), it is more important than ever that researchers and practitioners understand how to create curriculum that will authentically engage youth of color. To that end, there are important lessons public health researchers can learn from the fields of community psychology, education, and social work, among others. We explore the benefits of a youth-led research and action curriculum steeped in critical pedagogy and critical race theory focused on public health. Youth of color (N = 35) between the ages of 13 and 34 years from five U.S. cities were hired as researchers. The majority (57%) of youth were 16 or 17 years, and the gender split was female (57%) and male (43%). Key informant interviews with adults and qualitative data analysis techniques were employed to examine program products and outcomes. Materials were deductively coded for content related to critical pedagogy and race theory (e.g., empowerment, capacity building and community engagement, skill development) as well as conceptualizations of health. Findings indicate young people (a) began to think more consciously about health, what it means to be healthy, and the factors that influence health; (b) developed critical skills; and (c) described feeling empowered. When given resources and space to lead, we found youth to be insightful, resourceful, compassionate, and deeply committed to improving the lives of their peers, family members, and communities.
Relationship between Health-Related Quality of Life and Suicide Ideation in a Nationally Representative Sample of Elderly Koreans

Purpose : This study was implemented to identify the risk conditions influencing suicidal ideation in a nationally representative sample of elderly South Koreans. Methods : Data from 1,152 men and 1,581 women aged 65 years or older were gathered from the 2013 and 2014 Korea National Health and Nutrition Examination Survey VI. All analyses were performed using SPSS. To determine significant correlations between risk condition and suicidal ideation, a t-test was used. Results : There were differences in suicidal ideation according to the following individual factors: age, educational background, marital status, economic activity, recognition of stress, experience of depression, and economic status. There were differences in suicidal ideation according to the following health-related factors: subjective health status, EQ-5D (EuroQoL-5 Dimensions), hours of sleep, and BMI. There were also differences in suicidal ideation according to the following disease-related factors: HTN, COPD, asthma, stroke, depression and osteoarthritis. Conclusion : The findings indicate that broad intervention programs should be distributed to prevent suicidal ideation. It is also recommended that programs be developed in a way that can help manage the variables identified in this study. Furthermore, follow-up studies should be conducted to verify the program.
Identification and mapping QTLs of bolting time in purple cai-tai (Brassica rapa L. var. purpurea)

Bolting time is a crucial agronomic trait for yield and quality in purple cai-tai (Brassica. rapa L. var. purpurea), but the genetic mechanism controlling the procedure remains unknown. In the present study, a double haploid (DH) population derived from two inbred lines of purple cai-tai 4-1 and 040-3 was constructed to identify the quantitative trait loci (QTLs) of bolting time. Genetic linkage map was performed by JoinMap version 3.0 using SSR, SRAP and ESTP molecular markers. A total of one hundred and thirty-eight molecular markers were integrated into ten linkage groups (LGs), which were anchored to the corresponding chromosome of the B. rapa reference genome. The genetic linkage map covers 1253.1 cM, with an average distance of 9.08 cM between two adjacent markers. Five quantitative trait loci (QTLs) were identified to control bolting time and explaining variations from 17.7 to 44.2%. The genetic results of bolting time will be useful for future breeding of late bolting in purple cai-tai. Key words: Purple cai-tai (Brassica rapa L. var. purpurea), bolting time, quantitative trait loci (QTL).