Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Green Announcements on Stock Returns of New Zealand Listed Companies

The purpose of this paper is to investigate the effect of corporate green announcements on the stock performance of listed companies in New Zealand. We find that the market has a positive, though not significant, reaction to the announcements. New Zealand companies are largely viewed to be already quite green at the onset and the market is not very much surprised by such announcements but expect them to continue being green. Our results are consistent with the view that to be green is costly, especially so in a developed economy where the cost of doing business is high. Our findings underscore the importance for corporate managers in New Zealand that, while any positive green announcements that they make might not have a significant market reaction, they are nonetheless positive.
The Relationships Among Occupational Safety Climate, Patient Safety Climate, and Safety Performance Based on Structural Equation Modeling

Objectives The aim of the present study was to investigate the relationships among hospital safety climate, patient safety climate, and safety outcomes among nurses. Methods In the current cross-sectional study, the occupational safety climate, patient safety climate, and safety performance of nurses were measured using several questionnaires. Structural equation modeling was applied to test the relationships among occupational safety climate, patient safety climate, and safety performance. Results A total of 211 nurses participated in this study. Over half of them were female (57.0%). The age of the participants tended to be between 20 years and 30 years old (55.5%), and slightly more than half had less than 5 years of work experience (51.5%). The maximum and minimum scores of occupational safety climate dimensions were found for reporting of errors and cumulative fatigue, respectively. Among the dimensions of patient safety climate, non-punitive response to errors had the highest mean score, and manager expectations and actions promoting patient safety had the lowest mean score. The correlation coefficient for the relationship between occupational safety climate and patient safety climate was 0.63 (p<0.05). Occupational safety climate and patient safety climate also showed significant correlations with safety performance. Conclusions Close correlations were found among occupational safety climate, patient safety climate, and nurses’ safety performance. Therefore, improving both the occupational and patient safety climate can improve nurses’ safety performance, consequently decreasing occupational and patient-related adverse outcomes in healthcare units.
Scalable network estimation with L0 penalty

With the advent of high‐throughput sequencing, an efficient computing strategy is required to deal with large genomic data sets. The challenge of estimating a large precision matrix has garnered substantial research attention for its direct application to discriminant analyses and graphical models. Most existing methods either use a lasso‐type penalty that may lead to biased estimators or are computationally intensive, which prevents their applications to very large graphs. We propose using an L0 penalty to estimate an ultra‐large precision matrix (scalnetL0). We apply scalnetL0 to RNA‐seq data from breast cancer patients represented in The Cancer Genome Atlas and find improved accuracy of classifications for survival times. The estimated precision matrix provides information about a large‐scale co‐expression network in breast cancer. Simulation studies demonstrate that scalnetL0 provides more accurate and efficient estimators, yielding shorter CPU time and less Frobenius loss on sparse learning for large‐scale precision matrix estimation.
Association of traumatic stress and posttraumatic stress disorder with carotid atherosclerosis: findings from the general population

ABSTRACT Background: Cumulative evidence suggests that both traumatic stress and posttraumatic stress disorder (PTSD) are cross-sectionally and prospectively linked to cardiovascular disease (CVD). However, their association with proxy markers of atherosclerosis has hardly been investigated. Objective: The objective of this general population study was to relate traumatic stress and PTSD to carotid plaque and intima-media thickness (cIMT). Methods: 3119 adults from the general population were assessed regarding their traditional cardiovascular risk factors, and an ultrasound of the carotid arteries was performed in each participant. Based on a PTSD interview, every participant was assigned to one of three groups: no trauma; trauma, but no PTSD; and trauma with PTSD. The sample was stratified into five age groups. Results: Trauma exposure was reported by 54.5% of the sample and 2.0% had PTSD. Traumatized participants had increased odds of self-reported CVD events compared to those without trauma exposure, even when accounted for CVD risk factors and other covariates (odds ratio [OR] = 1.51; 95% confidence interval [CI]: 1.03–2.22). This association was driven by those aged 70 years or older. Only in those aged 40 to 49 years, there was an association between cIMT and PTSD. There were no further associations between carotid plaque or cIMT and traumatic stress or PTSD. Conclusions: Our findings in concert with prior research suggest that the association between traumatic stress, PTSD and atherosclerosis as well as its clinical endpoints is complex and remains inconclusive. HIGHLIGHTS: Although traumatic stress and posttraumatic stress disorder have been linked to cardiovascular disease, they were not related to proxy markers of atherosclerosis in this general population study including 3119 adults.
Postacute COVID-19: An Overview and Approach to Classification

Abstract As the coronavirus disease 2019 (COVID-19) pandemic has progressed, a large volume of literature has developed delineating the clinical manifestations of acute infection. Recent reports have also started to describe persistent symptoms extending beyond the period of initial illness or hospitalization. Anecdotes of different signs and symptoms occurring after acute infection have also arisen in the lay press. Here we describe the current existing medical literature on the emerging concept of postacute COVID-19 and suggest an approach to classifying different manifestations of the syndrome. We also review long-term clinical manifestations observed in patients who recovered from infection due to other epidemic coronaviruses and briefly discuss potential mechanisms driving the phenomenon of postacute COVID-19.
Word learning in monolingual and bilingual children: The influence of speaker eye-gaze

Abstract The current study examined the impact of a speaker's gaze on novel-word learning in 4-5-year old monolingual (N = 23) and bilingual children (N = 24). Children were taught novel words when the speaker looked at the object both times while labeling it (consistent) and when the speaker looked at the object only the first time (inconsistent). During teaching, bilingual children differentiated between the target object (that matched the label) and non-target object (that did not match the label) earlier than the monolingual children on trials without eye-gaze information. However, during testing, monolingual children showed more robust retention of novel words than bilingual children in both conditions. Findings suggest that bilingualism shapes children's attention to eye-gaze during word learning, but that, ultimately, there is no bilingual advantage for utilizing this cue in the service of word retention.
Improving central line needle insertions using in-situ vascular reconstructions

ABSTRACT We developed a neck central line insertion guidance system that renders 3D ultrasound (US) surface reconstructions of the carotid artery (CA) and internal jugular vein (IJV), a tracked model of the needle, and needle trajectory on a 2D monitor. Twenty clinicians evaluated this system compared to US-only guidance on a phantom using time and insertion accuracy metrics. The 3D system had a 100% success rate compared to 70% for the US-only system. The average distance from the centre line of the US reconstructed IJV was mm under D guidance compared to mm for US-only. Our system significantly improved needle insertion success rates and targeting accuracy compared to the US-only approach through a radiation-free surface reconstruction of the neck vascular structures. This work has the potential to provide a mobile 3D imaging and visualisation system for needle-based vascular interventions.
Early detection of small volume stroke and thromboembolic sources with computed tomography: Rationale and design of the ENCLOSE study

Background Computed tomography is the most frequently used imaging modality in acute stroke imaging protocols. Detection of small volume infarcts in the brain and cardioembolic sources of stroke is difficult with current computed tomography protocols. Furthermore, the role of computed tomography findings to predict recurrent ischemic stroke is unclear. With ENCLOSE, we aim to improve (1) the detection of small volume infarcts with thin slice computed tomography perfusion (CTP) images and thromboembolic source with cardiac computed tomography techniques in the acute stage of ischemic stroke and (2) prediction of recurrent ischemic stroke with computed tomography-derived predictors. Methods/design: ENCLOSE is a prospective multicenter observational cohort study, which will be conducted in three Dutch stroke centers (ClinicalTrials.gov Identifier: NCT04019483). Patients (≥18 years) with suspected acute ischemic stroke who undergo computed tomography imaging within 9 h after symptom onset are eligible. Computed tomography imaging includes non-contrast CT, CTP, and computed tomography angiography (CTA) from base of the heart to the top of the brain. Dual-energy CT data will be acquired when possible, and thin-slice CTP reconstructions will be obtained in addition to standard 5 mm CTP data. CTP data will be processed with commercially available software and locally developed model-based methods. The post-processed thin-slice CTP images will be compared to the standard CTP images and to magnetic resonance diffusion-weighted imaging performed within 48 h after admission. Detection of cardioembolic sources of stroke will be evaluated on the CTA images. Recurrence will be evaluated 90 days and two years after the index event. The added value of imaging findings to prognostic models for recurrent ischemic stroke will be evaluated. Conclusion The aim of ENCLOSE is to improve early detection of small volume stroke and thromboembolic sources and to improve prediction of recurrence in patients with acute ischemic stroke.
High-throughput sequencing reveals a high prevalence of pretreatment HIV-1 drug resistance in Sweden.

OBJECTIVES HIV-1 pretreatment drug resistance (PDR) is a global concern. Our aim was to evaluate high-throughput sequencing (HTS) for HIV-1 resistance testing and describe PDR in Sweden, where 75% of diagnosed individuals are foreign-born. DESIGN Cross-sectional study. METHODS Individuals entering HIV-1 care in Sweden 2017 to March 2019 (n = 400) were included if a viremic sample was available (n = 220). HTS was performed using an in-house assay. Drug resistance mutations (DRMs) (based on Stanford HIV DB vs. 8.7) at levels 1-5%, 5-19% and at least 20% of the viral population were described. Results from HTS and routine Sanger sequencing were compared. RESULTS HTS was successful in 88% of patients, 92% when viral load was at least 1000 copies/ml. DRMs at any level in protease and/or reverse transcriptase were detected in 95 individuals (49%), whereas DRMs at least 20% in 35 (18%) individuals. DRMs at least 20% correlated well to findings in routine Sanger sequencing. Protease/reverse transcriptase (PR/RT) DRMs at least 20% were predicted by treatment exposure; adjusted OR 9.28 (95% CI 2.24-38.43; P = 0.002) and origin in Asia; adjusted OR 20.65 (95% CI 1.66-256.24; P = 0.02). Nonnucleoside reverse transcriptase inhibitor (NNRTI) DRMs at least 20% were common (16%) and over-represented in individuals originating from sub-Saharan Africa or Asia. Low-level integrase strand transfer inhibitor (INSTI) DRMs less than 20% were detected in 15 individuals (8%) with no association with INSTI exposure. CONCLUSION Our HTS can efficiently detect PDR and findings of DRMs at least 20% compare well to routine Sanger sequencing. The high prevalence of PDR was because of NNRTI DRMs and associated with migration from areas with emerging PDR.
Dioecy in plants: an evolutionary dead end? Insights from a population genomics study in the Silene genus

About 15,000 angiosperm species (∼6%) have separate sexes, a phenomenon known as dioecy. Early work reported a lower species richness in dioecious compared to non-dioecious sister clades, which was taken to suggest that dioecy might be an evolutionary dead end. More recently, phylogenetic analyses using different methodologies have challenged this conclusion. Here, we used a population genomics approach to look for evidence of evolutionary handicaps of dioecy in the Silene genus at the molecular level. We obtained RNA-seq data of individuals from several populations in 13 closely related species with different breeding systems: seven dioecious, three hermaphroditic and three gynodioecious species. We show that dioecy is associated with increased genetic diversity and a higher selection efficacy both against deleterious and for beneficial mutations while controlling for differences in population size. We conclude that, in the Silene genus, dioecious species bear no sign of mutational burden or upcoming extinction. On the contrary, dioecious species harbor a higher potential for adaptation than their non-dioecious relatives. Our results do not support the evolutionary dead end hypothesis and re-open the question why dioecy is rare in angiosperms. Significance statement Dioecy (=separate sexes) is much rarer in flowering plants compared to animals and other organisms. The “dead-end hypothesis” states that dioecious plant populations might experience evolutionary handicaps such as low seed dispersal (as only 50% of the individuals, the females, contribute), which might cause high genetic drift, low adaptation and ultimately extinction. Here we tested this hypothesis by focusing on the genus Silene and by comparing the population genetics of 13 dioecious and non-dioecious species. We found that dioecious Silene species exhibit lower genetic drift and more adaptation compared to their non-dioecious relatives. Our results thus reject the dead-end hypothesis and re-open the question of why dioecy is rare in flowering plants.
From creativity to innovation and the role of competition networks: a cancer inspired two-step evolutionary agent-based model

ABSTRACT Inspired by the evolutionary dynamics of cancer, an agent-based model for creativity-innovation transition process is proposed. In this analogy, cells are considered as agents (e.g., companies or individual innovators) which are interacting with each other through a competitive interaction network; cancer represents the innovation and the creativity-innovation process is considered to be analogous to the necessary mutations needed within a cell to reach the cancerous state. In this process, agents move from doing business as usual to being creative and then finally innovative. The results show that in an industry with less frequent innovations, innovation emerges faster in structures with local connections. By moving towards more frequent innovations, structures with global and random connections show to be more effective. The outputs provide insights for policy-makers to assess different strategies to facilitate innovativeness for different types of industries. The model also provides a basis to further study the creativity-innovation process.
Evolution and Optimization of Urban Network Spatial Structure: A Case Study of Financial Enterprise Network in Yangtze River Delta, China

The urban network is an important method of spatial optimization, and measuring the development level of the urban network is a prerequisite for spatial optimization. Combining geographic information system (GIS) spatial analysis, social network analysis, and multidimensional scaling models, we explored the evolution of the urban network spatial structure in the Yangtze River Delta from 1990 to 2017 and proposed corresponding optimization measures. The results showed that the urban network spatial structure of the Yangtze River Delta has evolved from a single-center cluster with Shanghai as its core to a multi-center network with Shanghai as its core and Nanjing, Hangzhou, and Hefei as secondary cores. The density of the urban network has gradually expanded, but the strength of the connection between edge cities such as Chizhou, Suqian, and Quzhou and the core cities needs to be further improved. We found that the evolution of the urban network spatial structure has been driven by preferential attachment, path dependence, and differences in economic and industrial development. Finally, we propose optimizing the urban network spatial structure by strengthening the driving ability of the core cities, clarifying urban functions and development directions, and establishing a unified coordination mechanism. This paper enriches and deepens our understanding of the characteristics of the city network in the Yangtze River Delta, and provides a reference for the optimization of the urban network spatial structure.
A Functional Comparison of Swimming Behavior in Two Temperate Forest Ants (Camponotus pennsylvanicus and Formica subsericea) (Hymenoptera: Formicidae)

Abstract Water is a dangerous and often lethal obstacle for small terrestrial animals like insects. However, some ants survive this hazard by efficiently traversing the water surface. Swimming performance (velocity, acceleration, and efficiency) differs dramatically among ant species, yet the factors that affect performance remain unclear. Here, we investigate the relative importance of behavior and morphology to swimming performance using a comparative study of two temperate forest ant species having superficially similar morphology: Camponotus pennsylvanicus (De Geer, 1773) (Hymenoptera: Formicidae) and Formica subsericea (Say, 1836) (Hymenoptera: Formicidae). We also investigated how water surface tension and ant morphology enable some F. subsericea workers to walk across the water surface, whereas others swim partially submerged. Leg ablation experiments demonstrated that both species use their forelegs for propulsion and hind legs as stabilizers, whereas their midlegs effect both propulsion and stabilization during swimming. C. pennsylvanicus workers swam faster than F. subsericea workers, probably reflecting the larger body size and longer relative foreleg length of C. pennsylvanicus workers. F. subsericea workers that walked on water were somewhat smaller than swimming conspecifics, and no workers were able to walk on water when surface tension was reduced with ethanol. Collectively, these results and those of related studies suggest that, within a clade of ants, differences in swimming performance arise mainly from subtle morphological differences. The importance of ant ecology and cuticular chemistry in this context remains to be explored.
Determination of plasma parameters by spectral line broadening in an electrosurgical argon plasma

An electrosurgical argon plasma with a 5% admixture of molecular hydrogen is studied in order to investigate time averaged plasma parameters by optical emission spectroscopy (OES). Electron densities in the range of 1015–1016 cm−3 are determined from the Stark broadening of the time averaged line profiles of the Balmer-α and -β emission lines of hydrogen. A two-profile fit corresponding to regions of different electron densities is found to provide a better representation of the line broadening than a single profile fit. This is consistent with time resolved ICCD imaging, acquired with 150 ns time resolution, that shows strong radial gradients in the plasma emission and the asymmetry produced by the discharge arrangement. Gas temperatures are determined using two different methods. Firstly, simulated spectra for different rotational temperatures are fitted to the measured N2(C-B, 0-1) emission band originating from ambient air diffusion into the argon/hydrogen gas flow. From the best fit, rotational temperatures between 1500 K and 1800 K are inferred. These measurements are in good agreement with those inferred by the second method, which is based on the collisional broadening of the emission lines of neutral argon at 750 nm and 751 nm. This latter method may be useful for the measurement of gas temperatures when the device is used inside hollow organs during endoscopic or laparoscopic interventions, where air mixing will be limited. Therefore, the results of this study are highly relevant to applications of these devices, e.g. for controlling tissue effects and the avoidance of excessive heating.
Neovascularization Effects of Carbon Monoxide Releasing Drugs Chemisorbed on Coscinodiscus Diatoms Carriers Characterized by Spectromicroscopy Imaging

Silica microparticles made of diatomaceous earth have become particularly attractive materials for designing drug delivery systems. In order to investigate the use of natural diatoms as drug scaffolds for carbon monoxide releasing molecules (CORMs), we evaluated the chemisorption of the cis-[Re(CO)2Br4]2− complex (ReCORM-2) and its vitamin B12 derivative (B12-ReCORM-2) on Coscinodiscus frustules by 3D FT-IR spectroscopic imaging, and the drugs’ neovascularization effects in vivo in the zebrafish (Danio rerio) model. By mapping the symmetric Re-C≡O υ(CO) stretching vibration of the CORMs in the 2000 cm−1 region, we found that the drugs are mostly localized at the girdle band of the diatom frustule. Both ReCORM-2 and B12-ReCORM-2 retain their CO-releasing ability when chemisorbed on the diatoms. When applied in vivo at doses ≥25 µM, the molecules markedly reduced intersegmental and subintestinal vessels development in zebrafish, revealing high anti-angiogenic potential. In addition, diatom frustules did not provoke any toxic in vivo response in the zebrafish embryos, including inflammation. Overall, our results indicate that: (1) CORMs chemisorbed on diatom frustules retain their CO-releasing abilities; (2) both CO-releasing molecules show a concentration-dependent effect on the neovascularization in developing zebrafish; (3) silicate frustules are not toxic and could be used as CORMs drug carriers.
Sir Isaac Newton Stranger in a Strange Land

The theme of this essay is that the time of dominance of Newton’s world view in science is drawing to a close. The harbinger of its demise was the work of Poincaré on the three-body problem and its culmination into what is now called chaos theory. The signature of chaos is the sensitive dependence on initial conditions resulting in the unpredictability of single particle trajectories. Classical determinism has become increasingly rare with the advent of chaos, being replaced by erratic stochastic processes. However, even the probability calculus could not withstand the non-Newtonian assault from the social and life sciences. The ordinary partial differential equations that traditionally determined the evolution of probability density functions (PDFs) in phase space are replaced with their fractional counterparts. Allometry relation is proven to result from a system’s complexity using exact solutions for the PDF of the Fractional Kinetic Theory (FKT). Complexity theory is shown to be incompatible with Newton’s unquestioning reliance on an absolute space and time upon which he built his discrete calculus.