Miracle-dz/UniFAR-FTUs huggingface dataset:
CURCUMIN STRUCTURE-FUNCTION, BIOAVAILABLITY AND EFFICACY IN MODELS OF NEUROINFLAMMATION AND ALZHEIMER'S

Curcumin can reduce inflammation and neurodegeneration, but its chemical instability and metabolism raises concerns, including whether the more stable metabolite tetrahydrocurcumin (TC) may mediate efficacy. We examined the anti-oxidant, anti-inflammatory or anti-amyloidogenic effects of dietary curcumin and TC, either administered chronically to aged Tg2576 APP sw mice or acutely to LPS-injected wild-type mice. Despite dramatically higher drug plasma levels after TC compared to curcumin gavage, resulting brain levels of parent compounds were similar, correlating with reduction in LPS-stimulated iNOS, nitrotyrosine, F2 isoprostanes and carbonyls. In both the acute (LPS) as well as chronic inflammation (Tg2576), TC and curcumin similarly reduced IL-1beta. Despite these similarities, only curcumin was effective in reducing amyloid plaque burden, insoluble Abeta and carbonyls. TC had no impact on plaques or insoluble Abeta, but both reduced TBS-soluble Abeta and pJNK. Curcumin but not TC prevented Abeta aggregation. The TC metabolite was detected in brain and plasma from mice chronically fed the parent compound. These data indicate that the dienone bridge present in curcumin, but not in TC, is necessary to reduce plaque deposition and protein oxidation in an Alzheimer's model. Nevertheless, TC did reduce neuroinflammation and soluble Abeta, effects, which may be attributable to limiting JNK-mediated transcription. Because of its favorable safety profile and the involvement of misfolded proteins, oxidative damage and inflammation in multiple chronic degenerative diseases, these data relating curcumin dosing to the blood and tissue levels required for efficacy should help translation efforts from multiple successful preclinical models. In the acute paradigm, we investigated the differential impacts of curcumin versus TC on the drug levels in plasma and brain achieved and on the neuroinflammatory responses to an acute inflammatory stimulus (LPS) after different routes of administration. In the chronic model, we investigated curcumin metabolism and how chronic dietary administration of curcumin or TC modified A β and inflammatory parameters in an aging APP sw transgenic mouse model of AD. the again centrifuged and the supernatants were collected and used for determining protein concentration (Bio-Rad DC protein assay kit, CA) and iNOS levels by β (DAE) or GFAP stained sections were analyzed using NIH Image public domain software to calculate number of plaques, plaque burden and percent GFAP-area stained in cortical and hippocampal layers. Statistical analysis of variables was by 2x2 ANOVA (treatment x region).
Identification of Mesophylic Bacterial Flora in Deceased Worker Adults of Apis mellifera caucasia (Pollmann, 1889)

European honey bees (Apis mellifera L.) are among the most investigated insects in Turkey and globally, primarily because of their significant role in agriculture and the ecosystem and their high economic value. Honey bees are important not only for the honey, propolis, pollen, and wax they produce, but also as vital pollinators of agricultural and horticultural crops. A highly adaptable species, their range stretches from the southern parts of Scandinavia to Central Asia and throughout Africa (Sheppard & Meixner, 2003). A broad diversity of microorganisms is associated with honey bees (Engel et al., 2016). In recent years, severe losses of bees Abstract Apis mellifera, widely farmed around the world, is the most economically important species within the genus Apis. While the microbiota of live honey bees have been extensively examined, bacteria found in deceased honey bees (which might indicate infection or opportunistic pathogens) is in contrast poorly studied. Therefore, we decided to investigate the mesophilic bacterial flora of dead honey bees. So, in September 2013, dead adult worker honey bees were collected from 12 different cities, most of which were in the border provinces of Turkey. We identified bacterial isolates at the species level by using different morphological, biochemical, physical and molecular methods, in conjunction with molecular phylogenetic analysis. We constructed phylogenetic trees for isolated bacteria with the MEGA 6.0 program and neighbor-joining trees were reconstructed based on 16S rDNA gene sequences. The phylogenetic trees indicated that isolates DE003, DE007, DE011, DE001, DE019 and DE016, DE029 could be new members of the genera Erwinia, Acidovorax, Hydrogenophaga and Bacillus genus, respectively. In the bioassay study results, we observed that DE019 Hydrogenophaga sp. (64.7%) and DE004 Klebsiella grimontii (73.3%) had lethal effects on the honey bees. The other mortalities ranged from 10% to 25% (p>0.05), and according to a One-Way ANOVA analysis DE004 and DE019 significantly affect the A. mellifera caucasia in adult worker honey bees. This study is the first report of Hydrogenophaga as honey bee pathogen. Sociobiology An international journal on social insects
Comparison between girls and boys lifestyle profile and physical activity

O objetivo deste estudo foi comparar o perfil de estilo de vida e a pratica de atividade fisica entre meninas e meninos. Participaram do estudo 336 escolares, de 11 a 17 anos de de idade (51,5% sexo feminino). Foram avaliados a estatura, massa corporal, maturacao sexual e indice de massa corporal escore z (IMC-z). O nivel de atividade fisica (AF) foi analisado pelo International Physical Activity Questionnaire (IPAQ). O estilo de vida foi avaliado por meio do questionario Perfil do Estilo de Vida Individual (PEVI), analisando ototal de escores dos cinco componentes, considerando-se como pontos de corte: >30 pontos = PEVI favoravel e ≤30 pontos = PEVI desfavoravel. Observou-se que 35,1% dos escolares foram considerados acima do peso, 74,78% nao cumprem as recomendacoes de atividade fisica e 31,5% apresentaram PEVI desfavoravel. Existiu diferenca entre meninos e meninas para a pratica de atividade fisica moderada e vigorosa (AFMV) (p = 0,048). Os meninos apresentaram melhor estilo de vida (p = 0,06) e praticam em media mais AF leve (p < 0,01), AF moderada (p < 0,01), AF vigorosa (p < 0,01) e AFMV (p < 0,01) do que meninas. Enquanto as meninas com PEVI favoravel praticam em media mais AF leve do que aquelas com PEVI desfavoravel (p < 0,001). Concluiu-se que meninos praticam mais AF na semana em relacao as meninas, entretanto possuem menor preocupacao com comportamentos preventivos e relacionamentos. A pratica de AF leve foi maior em meninas com perfil de estilo de vida favoravel.
Software Survey for Breast Image Processing

– Computer-aided diagnosis (CAD) systems are computational tools that aim to help medical professionals in their diagnostic decisions. Software for processing images has contributed in many ways to medicine, such as, the diagnosis and treatments of diseases such as breast cancer. Breast cancer is one of the main causes of women death all over the world. However, early detection of the disease increases greatly the possibility of cure. Therefore, several types of computer systems based on image processing are being developed by many research groups in order to aid the radiologist in the accuracy of the diagnosis. The aim of this survey was to search for signs of the current state of technology, identifying image processing software in the global marketplace for assistance in medical diagnosis. The outcomes measured were obtained through the searches done in scientific publications repository Web of Science using the Derwent database, including records of deposits of world patents. Data measurement revealed that there were only 107 patent registrations. Further studies and research need to be designed, since the keyword “image processing software” showed only 3 patent registrations. The United States is the leader in the number of patents per country, with a total of 40 registrations in the abstract search. The title search resulted in only 20 registrations, although this quantity was much larger than that found in other countries. The this survey showed that there is a paucity of patent registration in lesser-developed and developing countries. The reasons may be the absence of a strategic enterprising vision for encouragement to improve technical and scientific endeavors.
Process for Predicting Stock Prices in the Financial Market using Big Data

– The financial market is very fickle and investors have the difficult task of following and trying to predict the market oscillations so that their strategies result in better financial returns. With the use of Big Data and Bayesian mathematical statistics based on prior knowledge and training examples to determine the likelihood of a hypothesis, financial news can be tracked continuously and affecting key financial indicators, actions and assisting the investor. The objective of this work is to propose a stock price prediction process of a listed company in the Ibovespa , helping an investor to better buy and sell stocks using a predictive system with Big Data and Natural Language Processing) to collect real-time information from news sites that may influence stock prices.
Methods in health psychology: how

volume 1 4 issue 4 Part of the charm of health psychology is the focus on direct applicability of our research results. There is also a risk in there, however, which is that our research can be focused more on obtaining applied results (e.g., the key determinants of achieving sufficient physical exercise within a particular population within a particular context) rather than contributing to a cumulative science through methodological and theoretical progress. Yet, the fact that our results might be applied immediately and influence behaviour of at-risk groups, prevention/health care workers, and policy makers, makes it even more important that the methods are sound and the conclusions valid. We need to take time to consolidate the methods we have established over the short life of our discipline and to identify the areas where we need to critique and improve our methods. We are therefore excited that EHPS has decided to run a Methods in health psychology track, starting in 2013 in beautiful Bordeaux.
A comparison between deep learning, naïve bayes and random forest for the application of data mining on the admission of new students

The process of admitting new students at Universitas Islam Negeri Raden Fatah each year produces a lot of new student data. So that there is an accumulation of student data continuously. The purpose of this study is to compare deep learning, naïve bayes, and random forest on the admission of new students as well as being one of the bases for making decisions to determine the promotion strategy of each study program. The data mining method used is knowledge discovery in database (KDD). The tools used are rapid miner. The attributes used are student ID number, name, program study, faculty, gender, place of birth, date of birth, year of entry, school origin, national examination, type of payment, and nominal payment. The new student data used from 2016 to 2019 was an 18.930 item. The results of this study used deep learning bayes results resulted in an accuracy value of 52.65%, naïve bayes results resulted in an accuracy value of 99.79%, and random forest results resulted in an accuracy value of 44.65%.
S-Adenosyl-L-Methionine protects the probiotic yest, <em>Saccharomyces boulardii</em>, from acid-induced cell death

Background: Saccharomyces boulardii is a probiotic yeast routinely used to prevent and to treat gastrointestinal disorders, including the antibiotic-associated diarrhea caused by Clostridium difficile infections. However, only 1-3% of the yeast administered orally is recovered alive in the feces suggesting that this yeast is unable to survive the acidic environment of the gastrointestinal tract. Results: We provide evidence that suggests that S. boulardii undergoes programmed cell death (PCD) in acidic environments, which is accompanied by the generation of reactive oxygen species and the appearance of caspaselike activity. To better understand the mechanism of cell death at the molecular level, we generated microarray gene expression profiles of S. boulardii cells cultured in an acidic environment. Significantly, functional annotation revealed that the up-regulated genes were significantly over-represented in cell death pathways Finally, we show that S-adenosyl-L-methionine (AdoMet), a commercially available, FDA-approved dietary supplement, enhances the viability of S. boulardii in acidic environments, most likely by preventing programmed cell death. Conclusions: In toto, given the observation that many of the proven health benefits of S. boulardii are dependent on cell viability, our data suggests that taking S. boulardii and AdoMet together may be a more effective treatment for gastrointestinal disorders than taking the probiotic yeast alone.
Disciplinary Power in The School: Panoptic Surveillance

The curiosity on how disciplinary power operates in a secondary school in the context of Panoptic surveillance became our motive. We designed the study as a single case study in qualitative approach to grasp the holistic understanding of disciplinary power, surveillance, and resistance to it in a secondary school. The data were obtained by a set of data collection techniques including a focus group interview, semi-structured interviews, observation and document analysis. The content analysis method was employed to analyze the collected data. In the analysis, we identified the themes of forced docility, norm provider, and reflection on discipline. To the findings, the main disciplinary power practice in this school is surveillance on appearances, behaviors, and exams, and the students prefer reacting to surveillance practices in two ways: either normalizing their behaviors or displaying resistance and insisting on the undesired behaviors. For further research, the relation between power, surveillance, and resistance can be analyzed as multiple case study to compare the findings at different types of school.
ACTA TECHNICA NAPOCENSIS

: Todays Vehicle-Electronics or Automotive-Electronics engineering becomes increasingly complex due to rapidly changing customer expectations regarding comfort, convenience, safety and especially aftermarket driven communication features. Thus, to handle such variety of functions or requirements the development complexity is divided into several electronic control units (ECU) interconnected via automotive specific communication channels (i
Oil Spill Removal from Water Surfaces using Zinc Ferrite Magnetic Nanoparticles as A Sorbent Material

In this study, zinc ferrite magnetic nanoparticles (ZnFe2O4, ZFO MNPs) were employed as a sorbent for the removal of oil spill from water surfaces. ZFO MNPs were synthesized via a sol-gel process and characterized by Fourier transform infrared spectroscopy (FTIR) and X-ray powder diffraction (XRD). Both the apparent density and magnetic force were determined. ZFO MNPs presented a considerable magnetic force (40.22 mN) and an adequate density (0.5287 g/cm 3 ), which are important for the magnetic separation and flotation. Four oil samples (gasoline engine oil, crude oil, used motor oil and diesel engine oil) were used to investigate the gravimetric oil removal capability of ZFO MNPs. The oil sorption capacities were found to be 23.00-6.13, 27.65-7.42, 22.62-7.01 and 30.54-9.93 g/g for crude, diesel engine, gasoline engine, and used motor oil, respectively. The current findings demonstrate that ZFO MNPs exhibit good properties (e.g., magnetic and density) and can be used as a sorbent for oil spill cleaning-up from water surfaces.
Viral Haemorrhagic Fever Epidemics and Health Workers: Investigating the Level of Preparedness in a Tertiary Hospital in Nigeria

Aim: This study assessed the state of infection prevention and control (IPC) with an emphasis on a hospital’s preparedness for mitigating the spread of viral haemorrhagic fevers (VHFs) to staff. Methods: This convergent parallel mixed-methods study obtained data on IPC using an observational checklist in clinical departments and units; key informant interviews of stakeholders; and a structured self-administered questionnaire with frontline health workers. Both qualitative and quantitative data analyses were conducted to determine the IPC practice and level of preparedness of the hospital for the threat of VHFs. Results: The frontline clinical staff who responded to the questionnaires were aged 31 – 40 years (53.8%), male (50.3%) and medical doctors (72.2%). Some of the respondents had received training in hand washing (41.5%), use of PPE (35.1%) and standard precaution for VHFs (26.8%). Fewer respondents consistently used gloves (36.8%), face masks (8.6%), aprons (8.5%) and sharps containers (26.7%) during patient care. Amenities available for IPC varied across the 184 clinical service points in the hospital’s 19 departments. More service points had waste bins (86%), washing sinks (80%) and running water (74%) while a few had a standard operating procedure for hand washing (6%) and cabinets for storing PPEs (12%). The most significant challenge to the use of IPC measures was the inadequacy of amenities such as full PPE gear, respirator, aprons, and face masks within the clinical service points. Conclusion: There is a poor level of preparedness for outbreaks of VHFs and this calls for strengthening administrative, engineering and environmental control in health facilities to stem outbreaks among health.
Factors Contributing to Low Teachers Competencies Score

Abstract: Competent teachers contribute to the students’ achievement significantly. Therefore, the government established a teacher professional development program with various activities. The program aims to improve their teaching skills, professional knowledge, and teaching effectiveness. However, many teachers have low competency even after joining the teacher professional development program. The low teacher competency score can be seen from the result of the teacher competency test. This research uses a quantitative design to investigate factors that contribute to the teachers’ competence. The results show factors that contribute to the low teachers’ competence are not doing classroom action research and writing article, rarely attending seminars or workshop, never being a speaker at seminars, low frequency of maintaining their English skill, not understanding the rights, mechanism, implementation of teacher competency test, not understandingng the objective of teacher competency test as a condition job promotion, and the unreadiness of the teacher in taking the examination.Abstrak: Guru yang kompeten berkontribusi terhadap prestasi siswa secara signifikan. Oleh karena itu, pemerintah membentuk program pengembangan profesional guru dengan berbagai kegiatan. Program ini bertujuan untuk meningkatkan keterampilan mengajar, pengetahuan profesional, dan efektivitas pengajaran mereka. Namun, banyak guru memiliki kompetensi rendah bahkan setelah mengikuti program pengembangan profesional guru. Skor kompetensi guru yang rendah dapat dilihat dari hasil tes kompetensi guru. Penelitian ini menggunakan desain kuantitatif untuk menyelidiki faktor-faktor yang berkontribusi terhadap kompetensi guru. Hasil penelitian menunjukkan faktor-faktor yang berkontribusi terhadap rendahnya kompetensi guru adalah tidak terbiasa melakukan penelitian tindakan kelas dan menulis artikel, jarang menghadiri seminar atau lokakarya, tidak pernah menjadi pembicara di seminar, rendahnya frekuensi guru dalam mempertahankan keterampilan bahasa Inggris mereka, tidak memahami hak, mekanisme, pelaksanaan tes kompetensi guru, tidak memahami tujuan tes kompetensi guru sebagai syarat promosi pekerjaan, dan ketidaksiapan guru dalam mengikuti ujian.
Employing the Empirical Mode Decomposition to Denoise the Random Telegraph Noise

Random Telegraph Noise (RTN) is a stochastic phenomenon which leads to characteristic variations in electronic devices. Finding features of this signal may result in its modeling and eventually removing the noise in the device. Measuring this signal is accompanied by some noise and therefore we require a method to improve the Signal to Noise Ratio (SNR). As a result, the extraction of an accurate RTN is a remarkable challenge. Empirical Mode Decomposition (EMD) as a fully adaptive and signal dependent method, with no dependency to the specific function, can be an appropriate solution. In this paper, we evaluate the most recent methods and compare them with our proposed approach for the artificial and actual RTN signals. The results show the higher accuracy and efficiency by about 54%, 61% and 39% improvement in SNR, Mean Square Error (MSE) and Percent Root mean square Difference (PRD) respectively for the optimized wited method. Finally, an indicator to evaluate the reliability in digital circuits is introduced.
Workplace engagement of South African Millennials: A non-issue?

Although theories on generational issues abound, this research sought to explore whether Millennial employees and employees from Generation X responded differently to the South African work environment. The aim of the study was to assess whether South African Millennials experience their work environment different to Generation X employees, focusing specifically on engagement and identifying the differential activation of engagement across these generations. Data from 1913 Millennials and 1027 Generation X employees, from an existing database representative of employees across the broad spectrum of South African organisations, were analysed. Data on the age of employees and responses to the employee engagement questionnaire (UWES-9) were available across all cases. The reliability of the instrument was tested first, followed by measurement invariance testing across generations. This was followed by mean differences testing between the generations on the total scores, as well as subscale scores and items. The results reveal that the UWES-9 was reliable and measurement invariant across generations. It further revealed that no mean differences exist between Generation X and Y (Millennials), as far as total engagement scores are concerned. This result is significant as it reveals that South African Millennials respond similarly to the generation preceding them to workplace engagement initiatives. The findings also indicate that Millennials respond well to interventions that help them build confidence and juggle multiple responsibilities.
Intensity clamping and re-focusing of intense femtosecond laser pulses in nitrogen molecular gas

We present results of measurements of fluorescence spectra due to the in- teraction of a Ti:sapphire laser pulse with N2 molecules at different gas pressures and pulse energies. The analysis of the data together with the results of numerical simu- lations, using a propagation model, reveal signatures of the phenomena of intensity clamping and of re-focusing of the laser pulse at high gas pressure. The laser pulse energy for intensity clamping as a function of the gas pressure is determined.