Miracle-dz/UniFAR-FTUs huggingface dataset:
Adhesion Receptor Activation of Phosphatidylinositol 3-Kinase

The cytoskeleton participates in the coordinated regulation of intracellular signaling molecules, following agonist stimulation of cells. We have demonstrated that von Willebrand factor (vWF) induced the cytoskeletal association and activation of phosphatidylinositol 3-kinase (PtdIns 3-kinase) in human platelets. The activation of PtdIns 3-kinase coincided with the tyrosine phosphorylation of multiple platelet proteins, as assessed by anti-phosphotyrosine immunoblotting. One of these tyrosine-phosphorylated proteins, pp6OC"", became specifically enriched in the cytoskeletal fraction of vWF-stimulated platelets. The vWF-stimulated cytoskeletal association of PtdIns 3-kinase and pp60c-8m required platelet stirring and aggregation, was pecifically blocked by an anti-GPIb monoclonal antibody, and was not observed in platelets lacking the glycoprotein Ib/M complex (Bernard-Soulier syndrome). Pretreatment of normal platelets with 5 m~ EDTA (37 "C for 90 min) or RGDS (2 m~), which disrupts the binding of various adhesive proteins to platelet integrins and inhibits fibrinogen-mediated platelet aggregation, did not alter the vWF-stimulated activation and cytoskeletal association of PtdIns 3-kinase and pp60"". Pretreatment of platelets with acetylsalicylic acid (1 m ~ ) completely abolished vWF-stimulated production of thromboxane 4, dense granule release, and the activation of protein kinase C, without altering the activation and cytoskeletal translocation of PtdIns 3-kinase and pp60""". Our results suggest that vWF binding to the platelet adhesion receptor glycoprotein Ib/M can mediate activation and translocation of both tyrosine and lipid kinase(s) independent of other agonists.
Is it Possible to Increase pCR in the Neoadjuvant Treatment With a Dose-Dense/Sequential Combination?: Results From a Phase II Trial Combining Epirubicin and Cyclophosphamide Followed by Paclitaxel and Gemcitabine ± Trastuzumab in Stage II and III Breast Cancer Patients

Purpose:To evaluate the pathologic complete response (pCR) rate of a combination of epirubicin (E) and cyclophosphamide (C) followed by paclitaxel (P) and gemcitabine (G) (+ trastuzumab[T]) in Her2+ patients) in a sequential and dose-dense schedule as neoadjuvant chemotherapy for stages II and III patients with breast cancer. Secondary endpoints: clinical response rate, disease free survival, safety and correlation between pCR and biologic markers. Patients and Methods:Eligible patients were treated with E (90 mg/m2) and C (600 mg/m2) for 3 cycles (first sequence) followed by P (150 mg/m2) and G (2500 mg/m2) (second sequence) for 6 cycles. All drugs were administered on day 1, every 2 weeks, with prophylactic growth factor support. Weekly T (2 mg/kg [4 mg/kg first infusion]) was administered concomitantly with P and G in Her2+ patients. A core biopsy was performed before treatment for biologic markers assessment. Patients underwent surgery, radiotherapy, and adjuvant hormonal therapy according to institutional practice. Results:Seventy-three patients were treated. A pCR was achieved in 27 (37%) patients (32.1%, Her2− and 50%, Her2+). pCR was significantly higher in tumors that were hormonal receptor negative, poorly differentiated and positive for Ki67 and p53. Breast-conserving surgery was performed in 47 patients (64.4%). Most frequent grade 3/4 hematologic and nonhematological toxicities included neutropenia (12%), nausea/vomiting (17%), and transient liver enzymes elevation (7%). One patient suffered an asymptomatic and reversible decrease in left ventricular ejection fraction. Conclusions:These results show a highly effective regimen in terms of pCR with a good toxicity profile in the neoadjuvant treatment of patients with breast cancer. The addition of trastuzumab increased pCR rate in Her2+ tumors.
Estimation of Morphological Tables Using Text Analysis Results

This paper proposes methods for obtaining input data, necessary for the modified morphological analysis method, from the text sources of data using text analysis tools. Several methods are described that are suitable for calculating initial estimates of alternatives and cross-consistency matrix values based on processing text fragments by rule-based categorization and sentiment analysis tools. A practical implementation of this tool set for assessing statements in news regarding Ukraine is considered.
Informed Guessing in Change Detection

Provided stimuli are highly distinct, the detection of changes between two briefly separated arrays appears to be achieved by an all-or-none process where either the relevant information is in working memory or observers guess. This observation suggests that it is possible to estimate the average number of items an observer was able to retain across a series of trials, a potentially highly informative cognitive characteristic. For each version of the change detection paradigm, for this estimate to be accurate, it is important to specify how observers use the information available to them. For some instantiations of this task it is possible that observers use knowledge of the contents of working memory even when they are in a guessing state, rather than selecting between the response alternatives at random. Here we test the suggestion that observers may be able to use their knowledge of the number of items in memory to guide guessing in two versions of the change detection task. The four experiments reported here suggest that participants are, in fact, able to use the parameters of the task to update their base expectation of a change occurring to arrive at more informed guessing.
Metabolic syndrome in obstructive sleep apnea and related cardiovascular risk

Background There is little evidence available about the relationship between metabolic syndrome as a comprehensive clinical entity and obstructive sleep apnea (OSA) with respect to the cardiovascular risk of patients with coexisting metabolic syndrome and OSA. Methods Eighty-nine consecutive patients (males 85%, aged 62 ± 11 years) with newly-diagnosed OSA were evaluated for the presence of metabolic syndrome and the incidence of cardiovascular events after implementation of continuous positive airway pressure (CPAP) therapy was registered during medium-term follow-up. The diagnosis of OSA and metabolic syndrome was obtained by overnight polygraphy [with a presence of an apnea-hypopnea index (AHI) ≥ 15] and following NCEP ATP III recommendations, respectively. Results Forty-seven (53%) OSA patients had coexisting metabolic syndrome, with increased waist circumference (98%), high blood pressure (89%) and decreased high-density lipoprotein-cholesterol (83%) as the most frequent features. OSA patients with metabolic syndrome were also younger (58 ± 11 years versus 65 ± 4 years, P < 0.001) and presented an higher AHI (43.5 ± 20.2 versus 34.8 ± 17.3, P < 0.05) as compared to those without metabolic syndrome. Follow-up lasted 22 ± 10 months. OSA patients who also presented metabolic syndrome suffered events less frequently compared to those who did not (6% versus 24%, P < 0.05), whereas the single end-points for follow-up (i.e. death, acute coronary syndrome, cerebrovascular event, peripheral vascular event, venous thromboembolism) did not significantly differ between the two groups. Conclusions Metabolic syndrome was a frequent comorbidity in OSA patients, reflecting higher degrees of sleep-disordered breathing, and did not increase the risk of cardiovascular events after adoption of CPAP therapy.
The Value of Adding Quality of Life Measures to Assessments of Outcomes in Mental Health

Objectives: In the domain of mental health outcomes, increasing interest has been shown in complementing traditional symptom measures with measures of a patient’s quality of life. The present study aimed to evaluate the value of including the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q; Endicott et al. 1993) into the routine assessment battery used at a private psychiatric hospital. Method: The sample consisted of 1276 consecutive inpatients treated at a private psychiatric hospital over a two year period. Admission and discharge data were collected for the Q-LES-Q, the mental health subscales of the Medical Outcomes Short Form Questionnaire (SF-36), the Depression Anxiety Stress Scale, and the Health of the Nation Outcome Scale. Results: Patient improvements from admission to discharge were seen across all instruments, including the Q-LES-Q. The Q-LES-Q was correlated with existing symptom measures, and regression analyses revealed predictive relationships between length of stay and quality of life even after symptoms of depression and anxiety were taken into account. Conclusions: Although the Q-LES-Q was correlated with symptom measures already in use, it added to the ability to predict patient length of stay, and showed some divergence from measures of clinical outcomes. This pattern was seen despite intentionally restricting the sample to patients with mood and affective disorder diagnoses. The value of considering quality of life in a comprehensive assessment of mental health outcomes is discussed.
Deformation of complex structures and the coupled Kähler–Yang–Mills equations

In this work, we define a deformation theory for the coupled Kähler–Yang–Mills equations, generalizing work of Székelyhidi on constant scalar curvature Kähler metrics. We use the theory to find new solutions of the equations via deformation of the complex structure of a polarized manifold endowed with a holomorphic vector bundle. We also study the deformations of the recent examples of Keller and Tø nnesen‐Friedman.
Structured home visits to older people. Are they only of benefit for women? A randomised controlled trial

Objective – To investigate whether education of primary care professionals improved functional ability in home-dwelling older people, with special focus on gender differences. Design – A prospective controlled three-year follow-up study (1999–2001) with randomisation and intervention at municipality level and outcomes measured at individual level. Intervention municipality visitors received regular education and GPs were introduced to a short assessment programme. Control municipalities received no education but conducted the preventive programme in their own way. Setting – Primary care, 34 municipalities. Subjects – 5788 home-dwelling 75- and 80-year-olds were invited. 4060 (70.1%) participated: 2104 in 17 intervention- and 1956 in 17 matched control-municipalities. The main outcome measure was obtained from 3383 (95.6%) of 3540 surviving participants. Main outcome measure – Functional ability. Results – Municipality intervention in coordination with GPs was associated with better functional ability in women (OR: 1.26; CI95: 1.08–1.47, p=0.004), but not in men (OR: 1.04; CI95: 1.85–1.27). Accepting and receiving free preventive home visits was associated with better functional ability among women (OR: 1.36; CI95: 1.16–1.60, p=0.0002), but not among men (OR: 0.98; CI95: 0.80–1.21). Conclusion – A brief, feasible educational intervention for primary care professionals and to accept and receive preventive home visits may have effect in older women, but not in older men.
Software and hardware architecture of advanced mobile robots for manufacturing

Modern manufacturing requires flexible and autonomous systems for materials handling and transportation. For such applications, a succession of implemented mobile robots has been developed over the past seven years. In this paper, the questions of software and hardware architecture are discussed in light of experience gained so far. Also discussed are mobile robot projects that seem realistic over the next five to ten years.
Supercooling of Water

Water has a complex phase diagram with more than 16 crystalline phases, two glass phases and liquid which displays many unique behaviors, especially in the region of -45 °C (Mishima and Stanley 1998, Stokely et al. 2010). It can remain a liquid even under conditions where a more stable phase exists, and in those conditions is said to be supercooled. Supercooled water can be prompted to turn into ice by seeding, and the best seed is ice itself. The nucleation of supercooled solutions has been studied for almost 300 years beginning with the early works by Fahrenheit (see Shaw et al. 2005). Water has long been known as an unusual liquid and significant research continues today into anomalies such as the compressibility (Abascal and Vega 2011) and the fascinating tendencies when water is confined to nanoscale dimensions (Strekalova et al. 2011). High pressure density fluctuations are also an ongoing research area (Mishima 2010), as is the so-called “no man’s land”, a region of the phase diagram existing below the homogeneous nucleation temperature (~ -38 °C) and above where amorphous ice can be found (~ -118 °C) (Moore and Molinero 2010).
A Semi-supervised approach to Document Clustering with Sequence Constraints

- Document clustering is usually performed as an unsupervised task. It attempts to separate different groups of documents (clusters) from a document collection based on implicitly identifying the common patterns present in these documents. A semi-supervised approach to this problem recently reported promising results. In semi-supervised approach, an explicit background knowledge (for example: Must-link or Cannot-link information for a pair of documents) is used in the form of constraints to drive the clustering process in the right direction. In this paper, a semi-supervised approach to document clustering is proposed. There are three main contributions through this paper (i) a document is transformed primarily into a graph representation based on Graph-of-Word approach. From this graph, a word sequences of size=3 is extracted. This sequence is used as a feature for the semi-supervised clustering. (ii) A similarity function based on common-word sequences is proposed, and (iii) the constrained based algorithm is designed to perform the actual cluster process through active learning. The proposed algorithm is implemented and extensively tested on three standard text mining datasets. The method clearly outperforms the recently proposed algorithms for document clustering in term of standard evaluation measures for document clustering task.
Fluid Dynamics Modelling Flow and Oscillations in Collapsible Tubes 1

Laboratory experiments designed to shed light on fluid flow through collapsible tubes, a problem with several physiological applications, invariably give rise to a wide variety of self-excited oscillations. The object of modelling is to provide scientific understanding of the complex dynamical system in question. This paper outlines some of the models that have been developed to describe the standard experiment, of flow along a finite length of elastic tube mounted at its ends on rigid tubes and contained in a chamber whose pressure can be independently varied. Lumped and one-dimensional models have been developed for the study of steady flow and its instability, and a variety of oscillation types are indeed predicted. However, such models cannot be rationally derived from the full governing equations, relying as they do on several crude, ad hoc assumptions such as that concerning the energy loss associated with flow separation at the time-dependent constriction during large-amplitude oscillations. A complete scientific description can be given, however, for a related two-dimensional configuration, of flow in a parallel-sided channel with a segment of one wall replaced by a membrane under longitudinal tension T . The flow and membrane displacement have been calculated successively by lubrication theory, Stokes-flow computation, steady Navier–Stokes computation and unsteady Navier–Stokes computation. For a given Reynolds number, Re, steady flow becomes unstable whenT falls below a critical value (equivalently, when Re exceeds a critical value for fixed T ), and the consequent oscillations reveal at least one period-doubling bifurcation as T is further reduced. The effect of wall inertia has also been investigated: it is negligible if the flowing fluid is water, but leads to an independent, high frequency flutter when it is air. The computations require very large computer resources, and a simpler model would be desirable. Investigation of the streamlines of the flow and the distribution of viscous energy dissipation reveals how the one-dimensional model might be improved; but such improvement is as yet
The Catechol-O-Methyl Transferase Val158Met Polymorphism and Susceptibility to Cannabis Dependence

Cannabis stimulates dopamine release and activates dopaminergic reward neurons in central pathways that lead to enhanced dependence. Catechol-O-methyl transferase (COMT) inactivates amplified extraneuronally released dopamine. A functional polymorphism (COMT Val158Met) resulting in increased enzyme activity has been associated with polysubstance abuse and addiction to heroin and methamphetamine. The aim of this study was to examine the relationship between the COMT Val158Met polymorphism and use of cannabis. Fifty-five cannabis users and 75 normal controls were enrolled in this study. Polymerase chain reaction-based genotyping was used to evaluate the presence of COMT gene polymorphism. There was a difference in genotype frequencies between cannabis users and controls, including the distribution of the COMT genotypes (H/H, H/L) (P < 0.001) and alleles (H, L) (P < 0.01), when comparing the patient groups and the control individuals. However, LL genotype distribution was similar between the groups. These results suggest a significant association between COMT Val158Met polymorphism and susceptibility to cannabis dependence.
Intracardiac masses: utility of contrast-enhanced echocardiography.

A 68-year-old patient, without relevant medical history, suffered from a syncope without prodromal signs. There were no constitutional symptoms such as fever or loss of weight. The ECG demonstrated sinus rhythm with a first-degree atrioventricular block. The transthoracic echocardio graphic study (TTE) showed preserved left and right systolic function. Attached to the interatrial septum, a giant left atrial mass, oscillating through the mitral valve in the left ventricle, was seen. However, the echo Doppler transmitral flow pattern could not document left ventricular inflow obstruction. The TTE images showed different echocardio graphic tissue characteristics of the basal and apical segments of the mass (figure 1, panel A). Transoesophageal echocardiography (TEE) confirmed the attachment of the heterogeneous mass to left atrial septum by a thin stalk (figure 1, panel B). Coronary angiography excluded severe coronary atherosclerosis. The vascular supply of the mass originated from the right coronary artery (figure 1, panel C). Contrast-enhanced (Sonoview, Braco Milan) TTE demonstrated a different density in contrast uptake, where the septal part of the mass was better vascularised (higher contrast uptake) compared with the apical segments of the mass (figure 1, panel D). The patient was referred for prompt resection of the mass to avoid embolic events.
DETECTION AND ACCURATE SIZING OF PCR PRODUCT BY AUTOMATED SCANNING: IMPROVED DETECTION OF IMMUNOGLOBULIN GENE REARRANGEMENTS IN ALL

in non-iron-loaded subjects could be very different from that which occurs in iron-loaded subjects. Kontoghiorghes (1 992) has pointed out the severe toxicity of desferrioxamine when given to non-iron-loaded individuals. No one denies that L1 has certain adverse reactions (agranuiocytosis, arthropathy) (Agarwalet al. 1993), but it is difficult to accept that L 1 has caused death due to immuno-paralysis or SLE from the data available so far.
Online feedback focusing algorithm for hyperthermia cancer treatment

Purpose: Magnetic resonance (MR) imaging is increasingly being utilized to visualize the 3D temperature distribution in patients during treatment with hyperthermia or thermal ablation therapy. The goal of this work is to lay the foundation for improving the localization of heat in tumors with an online focusing algorithm that uses MR images as feedback to iteratively steer and focus heat into the target. Methods: The algorithm iteratively updates the model that quantifies the relationship between the source (antenna) settings and resulting tissue temperature distribution. At each step in the iterative process, optimal settings of power and relative phase of each antenna are computed to maximize averaged tumor temperature in the model. The MR-measured thermal distribution is then used to update/correct the model. This iterative procedure is repeated until convergence, i.e. until the model prediction and MR thermal image are in agreement. A human thigh tumor model heated in a 140 MHz four-antenna cylindrical mini-annular phased array is used for numerical validation of the proposed algorithm. Numerically simulated temperatures are used during the iterative process as surrogates for MR thermal images. Gaussian white noise with a standard deviation of 0.3°C and zero mean is added to simulate MRI measurement uncertainty. The algorithm is validated for cases where the source settings for the first iteration are based on erroneous models: (1) tissue property variability, (2) patient position mismatch, (3) a simple idealized patient model built from CT-based actual geometry, and (4) antenna excitation uncertainty due to load dependent impedance mismatch and antenna cross-coupling. Choices of starting heating vector are also validated. Results: The algorithm successfully steers and focuses a tumor when there is no antenna excitation uncertainty. Temperature is raised to ≥43°C for more than about 90% of tumor volume, accompanied by less than about 20% of normal tissue volume being raised to a temperature ≥41°C. However, when there is antenna excitation uncertainty, about 40% to 80% of normal tissue volume is raised to a temperature ≥41°C. No significant tumor heating improvement is observed in all simulations after about 25 iteration steps. Conclusions: A feedback control algorithm is presented and shown to be successful in iteratively improving the focus of tissue heating within a four-antenna cylindrical phased array hyperthermia applicator. This algorithm appears to be robust in the presence of errors in assumed tissue properties, including realistic deviations of tissue properties and patient position in applicator. Only moderate robustness was achieved in the presence of misaligned applicator/tumor positioning and antenna excitation errors resulting from load mismatch or antenna cross coupling.