Miracle-dz/UniFAR-FTUs huggingface dataset:
MiR 206 inhibits reorganization of the cytoskeleton in melanoma cells by targeting DDX5

Purpose: To investigate the role and mechanism of microRNA-206 (miR-206) in cytoskeleton reorganization in melanoma cells. Methods: MiR-206 and RNA helicase p68 (DDX5) expression levels were measured in A375, A875, and HEM-M cells by quantitative real time polymerase chain reaction (qRT-PCR). A DDX5 overexpression cell line was constructed, and DDX5 overexpression, A375, and A875 cells were transfected with miR-206 mimic or DDX5 small interfering RNA (siRNA). Transwell assay was used to assess cell migration and invasion of A375 and A875 cells, while Luciferase reporter assay was used to determine the putative target of miR-206. DDX5, miR-206, vinculin, coronin3, and ezrin expression levels were evaluated by qRT-PCR. Protein expressions of DDX5, vinculin, coronin3, and ezrin were evaluated by western blot analysis. Results: DDX5 expression was higher and miR-206 expression lower in A375 and A875 cells when compared to HEM-M cells (p < 0.05). Knockdown of DDX5 and overexpression of miR-206 repressed invasion and migration, and inhibited expression of vinculin, coronin3, and ezrin in A375 and A875 cells (p < 0.05). However, overexpression of DDX5 reversed the effect of miR-206 on cytoskeletal protein expression. Luciferase reporter assay data confirmed that DDX5 is a direct target of miR-206 (p < 0.05). Conclusion: MiR-206 suppresses reorganization of the cytoskeleton in melanoma cells by targeting DDX5, and is thus, a promising target for the treatment of melanoma.
"Successful Treatment of Extranodal Natural Killer T Cell Lymphoma Nasal Type Complicated by Severe Hemophagocytic Syndrome A Case Report"

cessful Treatment of Extranodal Natural Killer T Cell Lymphoma Nasal Type Com plicated by Severe Hemophagocytic Syn drome high-grade fever, cough, chest pain and blood in phlegm. A chest computed tomography scan detected pneumonia-like features, including multiple variable nodules, ground-glass opacities and patchy infiltration, which progressed rapidly. The patient was initially diagnosed with severe pneumonia and received a combination treatment of broad-spectrum antibiotics ,however the patient’s condition continued to deteriorate. Biopsy of lung and soft tissue confirmed a diagnosis of extranodal NK/T-cell lymphoma, nasal type. Bone marrow aspiration did not show lymphoma involvement. The patient had progressive neutropenia upon presentation, with further investigations showing hepatosplenomegaly, hyperferritinemia, hypertriglyceridemia, low natural killer (NK) cell activity and increased circulating soluble IL-2 receptor. We reached a diagnosis of hemophagocytic syndrome. Chemotherapy and immunotherapy were started leading to a progressive improvement of the disease.
Remote Sensing Systems for Ocean: A Review (Part 1: Passive Systems)

Reliable, accurate, and timely information about oceans is important for many applications, including water resource management, hydrological cycle monitoring, environmental studies, agricultural and ecosystem health applications, economy, and the overall health of the environment. In this regard, remote sensing (RS) systems offer exceptional advantages for mapping and monitoring various oceanographic parameters with acceptable temporal and spatial resolutions over the oceans and coastal areas. So far, different methods have been developed to study oceans using various RS systems. This urges the necessity of having review studies that comprehensively discuss various RS systems, including passive and active sensors, and their advantages and limitations for ocean applications. In this article, the goal is to review most RS systems and approaches that have been worked on marine applications. This review paper is divided into two parts. Part 1 is dedicated to the passive RS systems for ocean studies. As such, four primary passive systems, including optical, thermal infrared radiometers, microwave radiometers, and Global Navigation Satellite Systems, are comprehensively discussed. Additionally, this article summarizes the main passive RS sensors and satellites, which have been utilized for different oceanographic applications. Finally, various oceanographic parameters, which can be retrieved from the data acquired by passive RS systems, along with the corresponding methods, are discussed.
Routing Strategies for LoRaWAN Multi-hop Networks: A Survey and an SDN-based Solution for Smart Water Grid

Low PowerWide Area Networks (LPWANs) are becoming the most suitable communication technologies in the Internet of Things (IoT) applications due to their low power consumption, long communication range and low cost. Currently, Long Range Wide Area Network (LoRaWAN) is one of the most popular LPWANs. Because it offers the possibility to build private networks with an open standard, LoRaWAN is the most deployed LPWAN solution. However, LoRaWAN supports only one-hop communication, that is, the end-devices are connected directly to the gateways. Since LoRa links can be kilometers long, its signals may undergo interference with other radio signals or encounter obstacles such as buildings, trees. In urban areas, to ensure that indoor LoRa devices can successfully transfer data back to remote gateways (GWs), a dense deployment of GWs is required. Unfortunately, the deployment of many GWs increases the network cost. Multi-hop communication can be exploited to increase LoRaWAN network coverage and packet delivery ratio (PDR) without deploying additional GWs. Therefore, in order to improve LoRaWAN performance, different routing approaches have been recently proposed aiming to create LoRaWAN multi-hop networks where some devices can play the role of relay nodes. However, in some use cases like SmartWater Grid (SWG), where nodes are buried underground inside the pipelines, the use of some SWG devices as relay nodes is not efficient in terms of energy consumption. In this paper, we first provide an in-depth survey on different routing protocols proposed for LoRaWAN multi-hop networks followed by a useful comparison between these approaches. Then, to enable efficient peer-2-peer (P2P) communication between end-devices in SWG, we propose a routing protocol based on Software Defined Networking (SDN) where some specific nodes called Relay Nodes (RNs) relay data from leakages detection nodes. In the case where a sensor detects a leak, a signal is sent to shut off the water valve automatically through our routing approach. Through simulations under LoRaSim, our proposed solution outperforms the standard single-hop network in terms of energy consumption and packet error rate. A range of issues, problems are provided and some research directions are suggested.
A 12-bit 100MS/s SAR ADC With Equivalent Split-Capacitor and LSB-Averaging in 14-nm CMOS FinFET

This paper presents an energy-saving and high-resolution successive approximation register (SAR) analog-to-digital converter (ADC) with 14-nm CMOS FinFET technology for wireless communication system. An Equivalent Split-Capacitor is proposed to enlarge redundancy range and alleviate the settling error of the bridge capacitor array. A hybrid capacitor switching procedure is adopted to reduce power consumption and the variation of input common-mode voltage of the comparator. Measurement results of the 14-nm CMOS SAR-ADC achieves a SNDR of 61.29 dB and 58.34dB at low and Nyquist input frequency, respectively, resulting in figure-of-merits(FoMs) of 8.2 and 11.15fJ/conversion-step, respectively. The ADC core occupies an active area 0.112mm2.
Annual Baseline King-Devick Oculomotor Function Testing Is Needed Due to Scores Varying by Age

Objective: To document baseline King-Devick (K-D) oculomotor function scores for male and female participants aged between 4 and 20 years old. Methods: Utilising a cross section of schools, rugby clubs and gymnastic clubs, 1936 participants (1300 male, 636 female) completed the spiral-bound K-D test for the identification of disturbed oculomotor function. Results: This study identified that overall, the baseline scores of the K-D test became faster by 1.4 (0.3 to 4.5) s per year, when compared with the previous age group in the same number of reading card groups. When comparing normative values of the original K-D validation study with the same age groups of the current cohort, participants aged 6 to 11 years recorded a faster baseline time (range 3.5 to 8.6 s), while those in the 12 to 14 years. age group recorded slower baseline times (range −3.9 to −7.9 s). Discussion: In general, there were age group differences, but not sex differences, for K-D test times in the current cohort. Analysis of single card times, across all age groups, showed changes likely due to improved reading time. Conclusion: The results support the need for individualised annual pre-injury baseline testing of the K-D test.
The Accuracy of TLM Analysis of Finned Rectangular Waveguides

This paper investigates three sources of error affecting the Transmission Line Matrix (TLM) analysis of finned rectangular waveguides. It is shown how truncation and velocity errors can be minimized, and a diagram for maximum coarseness error affecting the TLM analysis is presented. After error correction, cutoff frequencies obtained with the TLM method are in excellent agreement with results obtained with the Transverse Resonance Method.
Fault Analysis on VSI Fed Induction Motor Drive with Fault Tolerant Strategy

The aim of this study is to design and implement a fault tolerant inverter for induction motor drive. The operations of the induction motor drives are so crucial in some applications that any fault in the drive could result in serious loss to the industry in terms of capital, process and materials not to mention the wastage due to idle labor time. Hence, it is essentials that an induction motor drive should basically be fault tolerant. This study investigates some of the possible faults in the inverter circuits by performing fault analysis on the current waveforms using harmonic spectrum. A fault tolerant system is proposed which can operate even after occurrence of the fault in runtime. A new SIMULINK model for leg swap module is proposed. The simulation studies are done using MATLAB simulation tool and the results are presented. The hardware setup is configured, tested and the experimental results are compared with the simulation results.
A Triband U- Slot Patch Antenna with Enhanced Bandwidth and Isolation for MIMO Systems

The paper presents a compact tri band U slot microstrip patch antenna. The proposed antenna resonates at triband of 3.7GHz,5.8GHz and 7.1GHz frequencies for VSWR ≤ 2.5with an improved impedance bandwidth of 42% and a reduced mutual coupling of -23dB and the antenna is modified by using a shorting pin giving an improved bandwidth of 54% and isolation of -28dB which antenna resonates at tri band of 3.2GHz, 3.7GHz and 6.4 GHz frequencies for VSWR ≤ 1.6. The proposed antenna is a better choice for 4G, WLAN,Wi-MAX and Ultra Wide Band applications involving MIMO technique.
Prospective teachers’ opportunities to develop PCK from participation in learning study

ABSTRACT In this study, a learning study was used to enhance prospective teachers’ learning about how to teach a specific topic in mathematics or natural science to 4th-6th graders. It has been argued that participating in learning study can direct prospective teachers (PTs) towards the object of learning, and what needs to be enacted in teaching to make it possible for the learners to learn what is intended. However, less is known about what capabilities PTs develop from planning lessons in collaboration with peers and a teacher educator in learning studies. Our research question concerns what opportunities PTs have to develop pedagogical content knowledge (PCK) when participating in learning studies. We analyzed three groups’ lesson planning on two occasions, once when planning without a teacher educator, and once when planning with a teacher educator in a learning study using theory-informed questions. The software NVivo was used as a tool to code their discussions concerning PCK. For the three groups studied, there were significant differences regarding possibilities for developing PCK under the two conditions.
THE STUDY OF DOCUMENTS COUNTERFEIT PROCEDURES BY ANALYZING THE SECURITY ELEMENTS

The paper focuses on the counterfeiting of travel documents by identifying the safety elements. In this purpose, there are presented both new materials and manufacturing procedures of theses documents and the actual procedures of counterfeiting. There are also presented the specific methods of identifying and are analysed some case studies faced to their afferent specimens.
Intentional Teaming: Experiences from the Second National Healthcare Symposium

The second National Symposium on Healthcare Interpreting was developed and hosted by the CATIE Center of St. Catherine University in St. Paul, MN, on July 22-25, 2012. As one of six centers funded by the U.S. Department of Education, Rehabilitation Services Administration to advance interpreter education, the goal of this symposium is “to improve the understanding of the complex role of interpreters, including the linguistic, cultural, social and ethical challenges inherent in these settings” (CATIE Center, n.d., National Symposium on Healthcare Interpreting section, para. 2). In 2012, 135 Deaf and hearing interpreters, interpreter coordinators and health care providers from 25 states, Canada and Australia attended the symposium to access research and best practices in medical and mental health interpreting. Attendees had the opportunity to advance their understanding of the complex nature of healthcare interpreting work, particularly with peers and professionals. Plenary and concurrent sessions were presented in either American Sign Language (ASL) or English, with interpretation provided for nearly all sessions. The symposium audience of healthcare providers and experienced interpreters, combined with dense, technical content and varying interpretation needs, presented unique challenges for the symposium interpreting team. This article takes a closer look at those challenges and the process of intentional teaming that occurred so that the team could successfully provide effective interpreting services during the symposium. It also provides a documentation of the symposium’s successful team approach, processes and reflections. Note that the information in this article is provided with the consent of the interpreting team and the presenters’ gracious permission. Specific names are not used in the article because the focus is on the team and its dynamic rather than specific individuals. In this way, it is hoped that the examples and strategies shared can be applicable in other situations with different teams and events.
ACOUSTICS2008/893 Control parameters of a generalized vibrato model with modulations of harmonics and residual

Our previous research focused on vibrato modeling of the harmonics of musical sounds. We demonstrated the need to account for fundamental frequency modulation, global amplitude modulation, but also spectral envelope modulation linked to brightness modulations. This may result from non-linearities between the excitation signal and the resonating body, and/or from variable spectral sampling of the impedance function as F0 varies. For instance on flute, vibrato results from air pressure modulations. We also observed in sounds with vibrato of wind instruments that the residual also exhibits amplitude modulation, somehow due to air pressure modulations that are responsible vibrato. In a pilot listening test on shakuhashi sounds (for which the residual is obviously modulated), we asked participants to discriminate between the original modulated harmonics plus the amplitude modulated residual, and the original modulated harmonics plus a non-modulated residual, in a AB comparison task (same/dierent test). Preliminary results show that participants can hear the dierence, suggesting that the amplitude modulation on the residual is audible. Subsequently, we developed a generalized vibrato model incorporating modulations on harmonics and residual. This model is presented here with an emphasis on its control parameters.
Homology modeling, docking and molecular dynamics studies of some secondary metabolites of actinomycetes as biocontrol agents against the 3HNR enzyme of the phytopathogenic fungus Alternaria alternata

Abstract Early blight of tomatoes is a common disease caused by the phytopathogenic fungi Alternaria, in particular the species A. alternata. This disease causes significant losses in the tomato harvest. The enzyme 1,3,8-trihydroxynaphthalene reductase (3HNR) is a key enzyme involved in the production of melanin, that plays a crucial role in the process of fungi invasion. This enzyme is the target of some chemical fungicides, but the problem of resistance against these molecules requires the search for new molecules that are both effective and environment-friendly. Actinomycetes represent an important source of secondary metabolites with antimicrobial activity. Thus, in this study 110 secondary metabolites of actinomycetes were subjected to an in silico screening of their antifungal activity as possible inhibitors of the 3HNR of A. alternata. For this reason, the 3D structure of this enzyme was modeled. Then, a molecular docking study of the secondary actinomycetal metabolites was carried out within the catalytic site of the enzyme. Indole-3-carboxylic acid, Streptokordin, 3-Phenylpropionic acid, Phenylacetate, and 8-Hydroxyquinoline have shown the most promising results with binding energies of −6.1 kcal/mol, −6.1 kcal/mol, −5.4 kcal/mol, −5.3 kcal/mol, and −5.0 kcal/mol, respectively. These metabolites have also shown satisfactory results for drug-likeness and ADMET analysis. The interaction stability of the Streptokordin, Indole-3-carboxylic acid, Phenylacetate, and 8-Hydroxyquinoline within the catalytic site of 3HNR was confirmed by the results of the MD simulation and MM-PBSA analyzes. With their favorable interactive and pharmacokinetic characteristics, these metabolites may be potential antifungal molecules against A. alternata, and good candidates for further studies. Communicated by Ramaswamy H. Sarma
An age-stratified serosurvey against purified Salmonella enterica serovar Typhi antigens in the Lao People´s Democratic Republic

The epidemiology of typhoid fever in Lao People`s Democratic Republic is poorly defined. Estimating the burden of typhoid fever in endemic countries is complex due to the cost and limitations of population-based surveillance; serological approaches may be a more cost-effective alternative. ELISAs were performed on 937 serum samples (317 children and 620 adults) from across Lao PDR to measure IgG antibody titers against Vi polysaccharide and the experimental protein antigens, CdtB and HlyE. We measured the significance of the differences between antibody titers in adults and children and fitted models to assess the relationship between age and antibody titers. The median IgG titres of both anti-HylE and CdtB were significantly higher in children compared to adults (anti-HylE; 351.7 ELISA Units (EU) vs 198.1 EU, respectively; p<0.0001 and anti-CdtB; 52.6 vs 12.9 EU; p<0.0001). Conversely, the median anti-Vi IgG titer was significantly higher in adults than children (11.3 vs 3.0 U/ml; p<0.0001). A non-linear trend line fitted to the anti-CdtB and anti-HlyE IgG data identified a peak in antibody concentration in children <5 years of age. We identified elevated titers of anti-HlyE and anti-CdtB IgG in the serum of children residing in Lao PDR in comparison to adults. These antigens are associated with seroconversion after typhoid fever and may be a superior measure of disease burden than anti-Vi IgG. This approach is scalable and may be developed to assess the burden of typhoid fever in countries where the disease may be endemic, and evidence is required for the introduction of typhoid vaccines.
Gold Nanoclusters Grown on MoS2 Nanosheets by Pulsed Laser Deposition: An Enhanced Hydrogen Evolution Reaction

Au nanoparticles were decorated on a 2H MoS2 surface to form an Au/MoS2 composite by pulse laser deposition. Improved HER activity of Au/MoS2 is evidenced by a positively shifted overpotential (−77 mV) at a current density of −10 mA cm−2 compared with pure MoS2 nanosheets. Experimental evidence shows that the interface between Au and MoS2 provides more sites to combine protons to form an active H atom. The density functional theory calculations found that new Au active sites on the Au and MoS2 interface with improved conductivity of the whole system are essential for enhancing HER activity of Au/MoS2.
Compensation control and simulation of a tendon-sheath transmission system applied to lower limb exoskeleton robots

The tendon sheath system is widely used in occasions such as space limitation and long-distance transmission due to its simplicity, flexibility, and remote transmission ability. However, the non-linear characteristics produced by the friction and the flexibility of the tendon reduce the value of engineering applications. And also the change of pretension caused by curvature changing will lead to slack or disconnect of the system. In this paper, based on the previous researches of the tendon sheath, an elastic device connected in series with a double tendon sheath and a friction compensation law with time-varying accumulated bending angle were proposed. The proposed method can significantly reduce the change of pretension caused by bending angle change, with MAPE is 2.34% while the previous method is 25.93% and can significantly improve the anti-interference ability of the system. The proposed method was verified by a simulation and will be applied to the lower limb exoskeleton robots in subsequent research.
Multi-input DC/DC converter with ripple-free input currents

A multi-input DC/DC power converter with ripple-free input currents is proposed in this paper. In order to reduce the cost and size of the input inductors and achieve the electromagnetic interference (EMI) suppression, the coupled inductor technique is employed to obtain ripple-free input currents. With phase-shifted pulse width modulation (PWM) control, the converter can draw power simultaneously from two different voltage sources and deliver it to the load. The operation principle of the proposed converter has been analyzed in detail. The output voltage regulation and power flow control can be achieved by the proposed phase-shifted PWM control. Moreover, all the power switches in the proposed converter can be operated with either zero-voltage-switching (ZVS) at turn-on transition or zero-current-switching (ZCS) at turn-off transition. A prototype converter with two different DC voltage sources has been successfully implemented. Hardware experimental results are presented to verify the performance of the proposed multi-input DC/DC converter.
A catalogue of marine heatwave metrics and trends for the Australian region

Marine heatwaves around Australia, and globally, have been increasing in their frequency, intensity, and duration. This study reviews and catalogues marine heatwave metrics and trends around Australia since 1982, from near the beginning of the satellite sea-surface temperature observing period. The years in which the longest and strongest marine heatwaves around Australia occurred are also recorded. In addition, we analyse marine heatwaves in selected case study regions, and provide a short review of their associated impacts. These regions include: off the Western Australian coast, Torres Strait, Great Barrier Reef, Tasman Sea, and South Australian Basin. Finally, we provide a brief review of progress in understanding the potential predictability of sea surface temperature changes and marine heatwaves around Australia.