Miracle-dz/UniFAR-FTUs huggingface dataset:
Tumor-targeted docetaxel-loaded hyaluronic acid-quercetin polymeric micelles with p-gp inhibitory property for hepatic cancer therapy

Docetaxel (DTX) has profound effects on several hepatic cancer (HC) cells, but shows unsatisfactory clinical efficacy due to the lack of tumor specificity and p-gp mediated drug efflux. Herein, a novel targeted drug delivery nanosystem based on hyaluronic acid (HA) and quercetin (QU) was designed to improve the in vivo therapeutic efficacy of DTX on HC through HA-CD44 mediated targeting and QU-based p-gp efflux inhibition. DTX-loaded HA–QU polymeric micelles (DTX/HA–QU PMs) displayed a mean particle size of 176.8 ± 3.4 nm with a low polydispersity index (<0.2). The drug loading and entrapment efficiency were 23.6 ± 1.3% and 86.8 ± 1.8%, respectively. Not only did the nanosystem facilitate cellular uptake via HA-CD44 mediated endocytosis, but it also preferentially accumulated at the tumor site via the EPR effect. Moreover, DTX/HA–QU PMs showed prolonged circulation time and high stability in the bloodstream, and achieved AUC0–∞ and t1/2 values that were 3.0-fold and 5.51-fold higher than those of Taxotere®, respectively. In addition, an in vitro cytotoxicity study showed that DTX/HA–QU PMs were 13.6-fold more effective than Taxotere®, judging by the IC50. Importantly, DTX/HA–QU PMs presented the highest antitumor efficacy in a xenograft tumor-bearing mice model and the tumor inhibition ratio was 73.91%. Meanwhile, DTX/HA–QU PMs could down-regulate p-gp expression in tumor cells. These results suggested that the targeting moiety and p-gp efflux inhibitory property help DTX to accumulate at the tumor site and improve its antitumor efficacy in vivo.
Simultaneous Measurement of 3JHN,Hα and 3JHα,Hβ Coupling Constants in 13C,15N-Labeled Proteins

A triple-resonance NMR pulse sequence termed HA[HB,HN](CACO)NH is proposed that provides two types of 3JHH coupling constants sharing the Cα proton in amino acid spin systems. The experiment is of the quantitative J correlation-type and takes advantage of the favorable relaxation properties of 1Ha−13Cα multiple-quantum coherence as compared to schemes relying on antiphase magnetization. The problem of signal overlap is considerably reduced by calculating J values from cross-peak−cross-peak intensity ratios rather than referencing diagonal peaks. Application to flavodoxin from Desulfovibrio vulgaris yields a total of 282 3JHα,Hβ and 3JHN,Hα coupling constants, normally determined in two separate experiments, to be used in conjunction with heteronuclear couplings to derive angular constraints for the protein's backbone and side chains. While 3JHα,Hβ coupling constants indicate some extent of conformational averaging not in accord with fixed side chain torsion, excellent correlation of the experimental 3JHN,.
Hydration Properties and Interlayer Organization of Water and Ions in Synthetic Na-Smectite with Tetrahedral Layer Charge. Part 2. Toward a Precise Coupling between Molecular Simulations and Diffraction Data

A specific methodology was developed to collate the interlayer configurations resulting from Grand-Canonical Monte Carlo (GCMC) simulations with experimental X-ray and neutron diffraction data for two synthetic Na-saturated saponites having contrasting layer charge. Numerical simulations were performed assuming different existing sets of atomic partial charge and Lennard-Jones parameters for clay and water. For each parameter set and for the two samples in both the mono- and bihydrated states, the water contents resulting from GCMC simulations were first compared to water vapor desorption gravimetry data. The density distributions of interlayer species were then used to generate 00l intensities that were compared to X-ray and neutron diffraction data, the latter being recorded on both hydrogenated and deuterated specimens. The CLAYFF model [Cygan et al. J. Phys. Chem. B2004, 108, 1255] is shown to better account for water content and organization compared to the model developed by Skipper et al. (Clays Cl.
Fire-safe and environmentally friendly nanocomposites based on layered double hydroxides and ethylene propylene diene elastomer

In this work we describe layered double hydroxide (LDH), known as naturally occurring hydrotalcite, based rubber composites that can serve as outstanding fire retardant elastomeric materials. The preparation and detailed characterization of these composites are presented in this study. The inherent slow sulfur cure nature of EPDM rubber is considerably improved by the addition of LDH as realised by the observation of a shortening of the vulcanization time and an improvement of ultimate rheometric torque. This behavior of LDH signifies not only the filler-like character of itself, but also offers vulcanization active surface properties of layered double hydroxide particles. A good rubber–filler interaction was also realised by observing a positive shift of the glass transition temperature of ethylene propylene diene rubber (EPDM) in dynamic mechanical analysis (DMA). The flame retardant property was studied by the cone calorimeter test. The cone calorimeter investigation with sulfur cured gum rubber compounds found a peak heat release rate (PHRR) value of 654 kW m−2. However, at a higher phr loading of Zn–Al LDH i.e., at 40 phr and 100 phr, the PHRR is diminished to 311 kW m−2 and 161 kW m−2, respectively. Thus, this present work can pave the way to fabricate environmentally friendly fire retardant elastomeric composites for various applications.
Hybrid Phase Excitation Method for Improving Efficiency of 7-Phase BLDC Motors for Ship Propulsion Systems

This paper proposes a hybrid phase windings excitation method for improving the efficiency of a 7-phase brushless DC (BLDC) motor in the electric propulsion system of a ship. The electrical losses of a BLDC motor system depend on the operating region and the number of excited phase windings (2-phase, 4-phase or general 6-phase windings). In this paper the operating region and torque/speed characteristics according to the motor rotation speed and propeller load are analyzed for a number of excitation methods. In addition, it analyzes the electrical losses of the system under each of the excitation methods in the entire operating region of the motor. In every sampling time, the proposed control method calculates the electrical loss of the system for each of the excitation methods and operates a 7-phase BLDC motor by selecting the excitation method that results a decreased electrical loss at the operating speed. The usefulness of the proposed control algorithm is verified through experimental results.
Molecular imprinted photonic crystal for sensing of biomolecules

Abstract Molecularly imprinted polymers (MIPs) are highly cross-linked polymers with high binding capacity and selectivity to the target molecules. MIPs become increasingly important because of the potential applications in drug delivery, purification and separation. In spite of the tremendous progress that has been made in the molecular imprinting field, many challenges remain to be addressed, especially in transforming the binding event into a detectable optical signal. The combination of photonic crystal and molecular imprinting technique is becoming a popular research idea. Compared to the conventional MIPs, the molecularly imprinted photonic crystal sensors (MIPCB) have the advantage of directly convert the molecule recognition process into optical signal. This review comprehensively summarizes various MIPCB, including the principle of molecular imprinted photonic crystal sensors, recent development, some challenges and effective strategies for MIPCB.
Role of Religion in State Discourse: A Reappraisal of Islamization in Pakistan

1. Assistant Professor, Department of Political Science, Wahadat Road Science College, Lahore, Punjab, Pakistan 2. Assistant Professor, Department of Political Science, GC Women University, Sialkot, Punjab, Pakistan PAPER INFO ABSTRACT Received: February 03, 2018 Accepted: June 24, 2018 Online: June 30, 2018 Role of religion in state discourse is an old age phenomenon for the politicians. Constitutional secularism solved some issues yet the significance of religion in human perception cannot be minimized. For Pakistan’s constitutional development, the main question was not only about the acceptability of the role of Islam but also the kind of Islam to be established and extent of its influence into state system. The use of Islam as a political force with varying intensity has remained a frequent practice in Pakistan by civilian leadership as well as the military rulers. Their objectives behind that practice were, to acquire legitimacy, to strengthen their political positions and to consolidate their vested interests. The legacies about the establishment of political identity of Muslims in Sub-continent which was primarily, based on Islam played a critical role in post-partition period in Pakistan especially in manifesting the politics and power claims of various political parties and groups. The underlying study aims to explain the relationship between religion and politics in Pakistan since its inception and, to seek the role of religion in the constitutional development with reference to the use of Islam as a political instrument. The research concludes that not a single serious effort was made to incorporate the spirit of Islam in the constitution rather everything was politically motivated which has its own repercussions.
Antiepileptic and antimicrobial activities of novel 1-(unsubstituted/substituted)-3,5-dimethyl-1H-pyrazole derivatives.

A series of 1H-pyrazole derivatives (1a-f) were synthesized by cycloaddition of acetyl acetone with respective hydrazine derivatives in ether in the presence of sodium hydroxide to generate the corresponding pyrazole derivatives. The synthesized compounds were confirmed by melting point and TLC. The structure of synthesized compounds was established by elemental analysis and various analytical techniques such as IR and HNMR spectral studies. All the newly synthesized compounds were evaluated for their antiepileptic and antimicrobial activities.
Platinum Nanoparticles Supported on Activated Carbon Catalysts for the Gas-Phase Hydrodechlorination of Dichloromethane: Influence of Catalyst Composition and Operating Conditions

DCM is classified among the most hazardous atmospheric pollutants and therefore, the development of safe methods for the disposal of residual DCM is of great importance. Activated carbon- supported catalysts containing platinum nanoparticles as the active phase, with a high proportion of metal in the zero-valent state, were prepared in order to obtain catalysts of high performance in the gas-phase hydrodechlorination (HDC) of dichloromethane (DCM). Catalysts with Pt particles of sizes as low as 1.6 nm per average metal particle were obtained, leading to a high effectiveness in the dechlorination of effluent. All catalysts showed high initial dechlorination activity; however, a lower surface acidity in the support led to a higher stability of the conversion during the operation, as it avoids coke formation. When increasing metal load up to 2% (w/w), platinum nanoparticles of similar sizes originated, while a greater amount of Pt0 was obtained; this process therefore improved dechlorination activity to a significant extent. DCM conversion up to 90% and selectivity for non-chlorinated products higher than 90% were achieved. The influence of DCM concentration in the feed and the H2/DCM molar ratio was also investigated.
Effects of overburden, rock strength and pillar width on the safety of a three-parallel-hole tunnel

During the excavation of three-parallel-hole tunnel, the tunnel might collapse due to over-stress as a result of inadequate rock pillar width. Treating the rock overburden depth, rock strength, and rock pillar width as variables, a series of 3D numerical analysis was carried out to examine the effect of each variable on the safety of the tunnel, in particular the rock pillar. A stress strength ratio (SSR) was used to define whether the safety of the rock pillar was exceeded. A simple design chart for the case of three-parallel-hole tunnel, which took into account the influence of overburden depth, rock pillar width, and rock strength, was also proposed for used in the preliminary design stage.
Unbiased Estimators and Their Applications Vol. 2: Multivariate Case - V. G. Voinov; M. S. Nikulin.

Read more and get great! That's what the book enPDFd unbiased estimators and their applications vol 2 multivariate case will give for every reader to read this book. This is an on-line book provided in this website. Even this book becomes a choice of someone to read, many in the world also loves it so much. As what we talk, when you read more every page of this unbiased estimators and their applications vol 2 multivariate case, what you will obtain is something great.
Laboratory Research and Field Application of Polymer Flooding Technology with High Concentration and Large Pore Volume

According to the actual demands of Henan oilfield,laboratory research was conducted to find out the lower limit concentration and the best pore volume of high concentration polymer(ZL-I partially hydrolyzed polyacrylamide)flooding. The results showed that the viscosity increased gradually from 11.8 to 227.2 mPa·s when the polymer concentration increased from 500 to 3000 mg/L. The viscosity increased greatly when the polymer concentration was higher than 1670 mg/L. At the frequency of 0.1Hz,the viscous modulus increased obviously when the polymer concentration was higher than 1643 mg/L and the elastic modulus increased obviously when the polymer concentration was higher than 1680 mg/L. Therefore,the lower limit concentration of high concentration polymer flooding was 1700 mg/L. The enhanced oil recovery increased rapidly to 19.77% when the injection volume of 2000 mg/L polymer increased to 0.7 PV. But when the injection volume was more than 0.85 PV,the oil recovery increase improved slowly. It was suggested that the best polymer concentration suitable for Xia Er-men oilfield was 1800—2000 mg/L,and the most appropriate pore volume was 0.85 PV. After field application on 10 polymer injection wells,daily fluid production was891.3 t and daily oil production was 77.9 t,the cumulative oil production was 143498 t,the oil recovery increase of second polymer flooding was 8.66%,which indicated that high concentration and large pore volume polymer flooding could enhance oil recovery dramatically and improve economic benefit greatly.
Factors Predicting Stress among Nurses in the Situation of Unrest of the Four Southern Border Provinces of Thailand

Stress is a significant health problem among nurses working in areas of political unrest and war. It can pose a negative impact on local health systems. This study aimed to explore the relationship of factors and their ability to predict stress. Factors included the severity of the situation of unrest, sense of coherence, commitment, self-efficacy, and social support that exists among nurses in these situations. The subjects were 300 nurses selected by multi-stage random sampling. Data were analyzed using Pearson’s product-moment correlation, and stepwise multiple regression. The results indicated that the severity of the situation of unrest was positively significantly associated with stress among nurses at a high level (r = .527, p < .01) and sense of coherence (r = - .272, p < .01) was negatively significantly associated with stress among nurses at a low level.The severity of the situation of unrest, sense of coherence, and social support together predicted 32.2 % of the variance in stress among nurses. The severity of the situation of unrest was the most significant predictor of stress (27.7 %), followed by sense of coherence (3.4 %) and social support (2.1 %). Two factors associated with stress were the severity of the situation of unrest and sense of coherence, and three factors that predicted stress among nurses were the severity of the situation of unrest, sense of coherence, and social support. The findings can be used as basic data for nursing administrators to plan actions to prevent and deal with stress among nurses in situations of unrest by focusing on such predicting factors.
Analysis of High Moderation PWR MOX Core MISTRAL-4 with SRAC and MVP

An extensive experimental program, MISTRAL, is undertaken by NUPEC and CEA in order to measure the main core physics parameters of high moderation 100% MOX LWRs. The analysis of the MISTRAL-4, a mock-up of a full MOX PWR core was carried out by diffusion/transport calculations with the SRAC code system and by continuous-energy Monte Carlo calculations with the MVP code. The calculation results agreed with the experimental results of both calculations within experimental uncertainties and calculation results showed no specific trend caused by heterogeneity in highly-moderated mock-up core configurations.
Autonomous Payload Thermal Control

In small satellites there is less room for heat control equipment, scientific instruments, and electronic components. Furthermore, the near proximity of the electronics makes power dissipation difficult, with the risk of not being able to control the temperature appropriately, reducing component lifetime and mission performance. To address this challenge, taking advantage of the advent of increasing intelligence on board satellites, a deep reinforcement learning based framework that uses Soft Actor-Critic algorithm is proposed for learning the thermal control policy onboard. The framework is evaluated both in a naive simulated environment and in a real space edge processing computer that will be shipped in the future IMAGIN-e mission and hosted in the ISS. The experiment results show that the proposed framework is able to learn to control the payload processing power to maintain the temperature under operational ranges, complementing traditional thermal control systems.
Biomass waste dissolution with imidazole ionic liquids for biohydrogen production

Cellulosic biomass waste from municipal solid and agricultural biomass residue are Second Generation energy source, mainly contain glucose and xylose monomers, were`extensively studied in present research for fermentable sugar hydrolysate in biohydrogen production. Scrap paper cup (SPC), bamboo stem wall (BSW), sugar cane bagasse (SCB) and oil palm empty fruit bunch (OPEFB) were dissolved in laboratory prepared imidazole ionic liquids; 1-allyl-3-methylimidazolium chloride ([Amim]Cl) and 1-butyl-3-methylimidazolium chloride ([Bmim]Cl). A comparative study on biomass composition was presented by Van Soest and thermalgravimetric analysis (TGA) method. TGA was proved as comparative, cheaper and faster method in measuring the lignoellulose composition. Experimental result show that the ionic liquids were completely dissolved the SPC, BSW, SCB and OPEFB with high cellulose recovery; 96.00%, 91.34% 87.16% and 99.51% respectively. The used ionic liquids were highly recovered from the mixture at 94% to 99% recovery rate and FTIR analysis proofed that the recycled ionic liquid is principally consistent with the original. The regenerated cellulose was undergo acid hydrolysis to reducing sugars (glucose/xylose) hydrolysate to be used as feedstock fermentation for biohydrogen production. Acid hydrolysis of the recovered cellulose resulted up to 96% sugar conversion. IL-SPC hydrolysate reported higher total sugar conversion compare to SPC (control) due to higher surface area and disintegration of the cellulosic fibril structure resulted from the dissolution process. IL-SPC, IL-BSW, IL-SCB and IL-OPEFB hydrolysate contained higher total sugar compared to SPC hydrolysate even though their cellulose recovery are lower that the SPC (control). Biohydrogen fermentability test of this hydrolysate was carried out using biohydrogen producing bacterium Clostridia sp. Almost 85% of biomass waste hydrolysate substrate was utilized by the bacteria. Up to 196 ml H 2 / 100 ml cumulative bioydrogen production was collected for fermentation using the biomass hydrolysate while 174.91 ml H 2 / 100 ml was produced from the control.
Elastic moduli of nanocrystalline binary Al alloys with Fe, Co, Ti, Mg and Pb alloying elements

Abstract The paper studies the elastic moduli of nanocrystalline (NC) Al and NC binary Al–X alloys (X is Fe, Co, Ti, Mg or Pb) by using molecular dynamics simulations. X atoms in the alloys are either segregated to grain boundaries (GBs) or distributed randomly as in disordered solid solution. At 0 K, the rigidity of the alloys increases with decrease in atomic radii of the alloying elements. An addition of Fe, Co or Ti to the NC Al leads to increase in the Young’s E and shear μ moduli, while an alloying with Pb decreases them. The elastic moduli of the alloys depend on a distribution of the alloying elements. The alloys with the random distribution of Fe or Ti demonstrate larger E and μ than those for the corresponding alloys with GB segregations, while the rigidity of the Al–Co alloy is higher for the case of the GB segregations. The moduli E and μ for polycrystalline aggregates of Al and Al–X alloys with randomly distributed X atoms are estimated based on the elastic constants of corresponding single-crystals according to the Voigt-Reuss-Hill approximation, which neglects the contribution of GBs to the rigidity. The results show that GBs in NC materials noticeably reduce their rigidity. Furthermore, the temperature dependence of μ for the NC Al–X alloys is analyzed. Only the Al–Co alloy with GB segregations shows the decrease in μ to the lowest extent in the temperature range of 0–600 K in comparison with the NC pure Al.
Effects of thermal barrier coating on the performance and combustion characteristics of a diesel engine fueled with biodiesel produced from waste frying cottonseed oil and ultra-low sulfur diesel

ABSTRACT In this study, the top surfaces of piston and valves of a four-strokes and direct-injection diesel engine have been coated—with no change in the compression ratio—with a 100 μm of NiCrAl lining layer via plasma spray method and this layer has later been coated with main coating material with a mixture of 88% of ZrO2, 4% of MgO and 8% of Al2O3 (400 μm). Then, after the engine-coating process, ultra-low sulfur diesel (ULSD) as base fuels and its blend with used frying cottonseed oil derived biodiesel in proportion of 20%, volumetrically, have been tested in the coated engine and data of combustion and performance characteristics on full load and at different speeds have been noted. The results, which were compared with those obtained by uncoated-engine operation, showed that thermal efficiency increased, and engine noise reduced. Cylinder gas pressure values obtained from the diesel engine which has been coated with thermal barriers have been found to be somewhat higher than those of the uncoated-engine. Also, maximum pressure values measured in both engines and under the same experimental conditions through the use of test fuel have been obtained after TDC. Moreover, heat release rate and heat release have occurred earlier in the coated-engine. NOx emissions were increased while CO and HC emissions were remained almost the same with a little bit decrease.