Miracle-dz/UniFAR-FTUs huggingface dataset:
Analyzing a German-language Expanded Form of the PhoPhiKat-45: Psychometric Properties, Factorial Structure, Measurement Invariance with the Likert-Version, and Self-Peer Convergence

Abstract Personality assessment typically relies on self-report questionnaires utilizing Likert-type scales. Recently, the Expanded format has been proposed as alternative, but research on the consequences of adapting Likert-like responses to Expanded items is sparse. We adapt a multidimensional measure into the Expanded format: the PhoPhiKat-45. This is the standard questionnaire to assess gelotophobia (fear of being laughed at), gelotophilia (joy in being laughed at), and katagelasticism (joy in laughing at others). We test the reliability, item/scale parameters, and factorial structure across the Expanded and Likert formats in three independently collected samples (Ns = 323/261/460). While the psychometric properties are satisfying, elevated item- and mean-scores in our experimental Expanded version do not support full measurement invariance with the Likert version—and, thus, it does not permit the application of established cutoff scores for gelotophobia. The convergence of self-peer ratings supports the validity of an Expanded version. Overall, an Expanded form of the PhoPhiKat-45 did not outperform the standard Likert version. We discuss potential trait- and method-related causes for the measurement invariance and consequences for the usage of cutoff scores in the assessment of gelotophobia as well as interpreting the findings in light of continued research on the Expanded response format.
Regulation of miR‐128 in the nucleus accumbens affects methamphetamine‐induced behavioral sensitization by modulating proteins involved in neuroplasticity

Methamphetamine (METH) ‐induced behavioral sensitization depends on long‐term neuroplasticity in the mesolimbic dopamine system, especially in the nucleus accumbens (NAc). miR‐128, a brain enriched miRNA, was found to have abilities in regulating neuronal excitability and formation of fear‐extinction memory. Here, we aim to identify the role of miR‐128 on METH‐induced locomotor sensitization of male mice. We identified a significant increase of miR‐128 in the NAc of mice upon repeated‐intermittent METH exposure but not acute METH administration. Microinjection of adeno‐associated virus (AAV)‐miR‐128 over‐expression and inhibition constructs into the NAc of mice resulted in enhanced METH‐induced locomotor sensitization and attenuated effects of METH respectively. Isobaric tags for relative and absolute quantification (iTRAQ) technology and ingenuity pathway analysis (IPA) were carried out to uncover the potential molecular mechanisms underlying miR‐128‐regulated METH sensitization. Differentially expressed proteins, including 25 potential targets for miR‐128 were annotated in regulatory pathways that modulate dendritic spines, synaptic transmission and neuritogenesis. Of which, Arf6, Cpeb3 and Nlgn1, were found to be participating in miR‐128‐regulated METH sensitization. Consistently, METH‐induced abnormal changes of Arf6, Cpeb3 and Nlgn1 in the NAc of mice were also detected by qPCR and validated by western blot analysis. Thus, miR‐128 may contribute to METH sensitization through controlling neuroplasticity. Our study suggested miR‐128 was an important regulator of METH‐ induced sensitization and also provided the potential molecular networks of miR‐128 in regulating METH‐induced sensitization.
Tendon Extracellular Matrix Remodeling and Defective Cell Polarization in the Presence of Collagen VI Mutations

Mutations in collagen VI genes cause two major clinical myopathies, Bethlem myopathy (BM) and Ullrich congenital muscular dystrophy (UCMD), and the rarer myosclerosis myopathy. In addition to congenital muscle weakness, patients affected by collagen VI-related myopathies show axial and proximal joint contractures, and distal joint hypermobility, which suggest the involvement of tendon function. To gain further insight into the role of collagen VI in human tendon structure and function, we performed ultrastructural, biochemical, and RT-PCR analysis on tendon biopsies and on cell cultures derived from two patients affected with BM and UCMD. In vitro studies revealed striking alterations in the collagen VI network, associated with disruption of the collagen VI-NG2 (Collagen VI-neural/glial antigen 2) axis and defects in cell polarization and migration. The organization of extracellular matrix (ECM) components, as regards collagens I and XII, was also affected, along with an increase in the active form of metalloproteinase 2 (MMP2). In agreement with the in vitro alterations, tendon biopsies from collagen VI-related myopathy patients displayed striking changes in collagen fibril morphology and cell death. These data point to a critical role of collagen VI in tendon matrix organization and cell behavior. The remodeling of the tendon matrix may contribute to the muscle dysfunction observed in BM and UCMD patients.
Families in comparison: An individual-level comparison of life-course and family reconstructions between population and vital event registers

It remains unknown how different types of sources affect the reconstruction of life courses and families in large-scale databases increasingly common in demographic research. Here, we compare family and life-course reconstructions for 495 individuals simultaneously present in two well-known Dutch data sets: LINKS, based on the Zeeland province’s full-population vital event registration data (passive registration), and the Historical Sample of the Netherlands (HSN), based on a national sample of birth certificates, with follow-up of individuals in population registers (active registration). We compare indicators of fertility, marriage, mortality, and occupational status, and conclude that reconstructions in the HSN and LINKS reflect each other well: LINKS provides more complete information on siblings and parents, whereas the HSN provides more complete life-course information. We conclude that life-course and family reconstructions based on linked passive registration of individuals constitute a reliable alternative to reconstructions based on active registration, if case selection is carefully considered.
Wisdom of the CROUD: Development and validation of a patient-level prediction model for opioid use disorder using population-level claims data

Objective Some patients who are given opioids for pain could develop opioid use disorder. If it was possible to identify patients who are at a higher risk of opioid use disorder, then clinicians could spend more time educating these patients about the risks. We develop and validate a model to predict a person's future risk of opioid use disorder at the point before being dispensed their first opioid. Methods A cohort study patient-level prediction using four US claims databases with target populations ranging between 343,552 and 384,424 patients. The outcome was recorded diagnosis of opioid abuse, dependency or unspecified drug abuse as a proxy for opioid use disorder from 1 day until 365 days after the first opioid is dispensed. We trained a regularized logistic regression using candidate predictors consisting of demographics and any conditions, drugs, procedures or visits prior to the first opioid. We then selected the top predictors and created a simple 8 variable score model. Results We estimated the percentage of new users of opioids with reported opioid use disorder within a year to range between 0.04%-0.26% across US claims data. We developed an 8 variable Calculator of Risk for Opioid Use Disorder (CROUD) score, derived from the prediction models to stratify patients into higher and lower risk groups. The 8 baseline variables were age 15–29, medical history of substance abuse, mood disorder, anxiety disorder, low back pain, renal impairment, painful neuropathy and recent ER visit. 1.8% of people were in the high risk group for opioid use disorder and had a score > = 23 with the model obtaining a sensitivity of 13%, specificity of 98% and PPV of 1.14% for predicting opioid use disorder. Conclusions CROUD could be used by clinicians to obtain personalized risk scores. CROUD could be used to further educate those at higher risk and to personalize new opioid dispensing guidelines such as urine testing. Due to the high false positive rate, it should not be used for contraindication or to restrict utilization.
Comparison of the TIMI, GRACE, PAMI and CADILLAC risk scores for prediction of long-term cardiovascular outcomes in Taiwanese diabetic patients with ST-segment elevation myocardial infarction: From the registry of the Taiwan Society of Cardiology

Acute coronary syndrome (ACS) patients with diabetes have significantly worse cardiovascular outcomes than those without diabetes. This study aimed to compare the performance of The Thrombolysis In Myocardial Infarction (TIMI), Global Registry of Acute Coronary Events (GRACE), Primary Angioplasty in Myocardial Infarction (PAMI), and Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) risk scores in predicting long-term cardiovascular outcomes in diabetic patients with ST-segment elevation myocardial infarction (STEMI). From the Acute Coronary Syndrome-Diabetes Mellitus Registry of the Taiwan Society of Cardiology, patients with STEMI were included. The TIMI, GRACE, PAMI, and CADILLAC risk scores were calculated. The discriminative potential of risk scores was analyzed using the area under the receiver-operating characteristics curve (AUC). In the 455 patients included, all four risk score systems demonstrated predictive accuracy for 6-, 12- and 24-month mortality with AUC values of 0.67–0.82. The CADILLAC score had the best discriminative accuracy, with an AUC of 0.8207 (p<0.0001), 0.8210 (p<0.0001), and 0.8192 (p<0.0001) for 6-, 12-, and 24-month mortality, respectively. It also had the best predictive value for bleeding and acute renal failure, with an AUC of 0.7919 (p<0.05) and 0.9764 (p<0.0001), respectively. Patients with CADILLAC risk scores >8 had poorer 2-year survival than those with lower scores (log-rank p<0.0001). In conclusion, the CADILLAC risk score is more effective than other risk scores in predicting 6-month, 1-year, and 2-year all-cause mortality in diabetic patients with STEMI. It also had the best predictive value for in-hospital bleeding and acute renal failure.
Area-Specific Synapse Structure in Branched Posterior Nucleus Axons Reveals a New Level of Complexity in Thalamocortical Networks

Thalamocortical posterior nucleus (Po) axons innervating the vibrissal somatosensory (S1) and motor (MC) cortices are key links in the brain neuronal network that allows rodents to explore the environment whisking with their motile snout vibrissae. Thalamocortical posterior nucleus (Po) axons innervating the vibrissal somatosensory (S1) and motor (MC) cortices are key links in the brain neuronal network that allows rodents to explore the environment whisking with their motile snout vibrissae. Here, using fine-scale high-end 3D electron microscopy, we demonstrate in adult male C57BL/6 wild-type mice marked differences between MC versus S1 Po synapses in (1) bouton and active zone size, (2) neurotransmitter vesicle pool size, (3) distribution of mitochondria around synapses, and (4) proportion of synapses established on dendritic spines and dendritic shafts. These differences are as large, or even more pronounced, than those between Po and ventro-posterior thalamic nucleus synapses in S1. Moreover, using single-axon transfection labeling, we demonstrate that the above differences actually occur on the MC versus the S1 branches of individual Po cell axons that innervate both areas. Along with recently-discovered divergences in efficacy and plasticity, the synaptic structure differences reported here thus reveal a new subcellular level of complexity. This is a finding that upends current models of thalamocortical circuitry, and that might as well illuminate the functional logic of other branched projection axon systems. SIGNIFICANCE STATEMENT Many long-distance brain connections depend on neurons whose branched axons target separate regions. Using 3D electron microscopy and single-cell transfection, we investigated the mouse Posterior thalamic nucleus (Po) cell axons that simultaneously innervate motor and sensory areas of the cerebral cortex involved in whisker movement control. We demonstrate significant differences in the size of the boutons made in each area by individual Po axons, as well as in functionally-relevant parameters in the composition of their synapses. In addition, we found similarly large differences between the synapses of Po versus ventral posteromedial thalamic nucleus axons in the whisker sensory cortex. Area-specific synapse structure in individual axons implies a new, unsuspected level of complexity in long-distance brain connections.
Effect of Different Types of Messages on Readiness to Indicate Willingness to Register for Organ Donation During Driver’s License Renewal in Japan

Background. In Japan, a recent opinion poll in 2017 showed that 41.9% of the respondents wished to donate their organs, but only 12.7% declared their intention to donate or not do so. Therefore, it is important to explore measures to prompt more individuals to register their intention about organ donation. Methods. A field experimental questionnaire survey was conducted to confirm the effect of a prompt message for registering intentions for organ donation, which was communicated at a driver’s license center. The study employed a prospective randomized control design. Seven thousand six hundred fifteen individuals visited the Tokyo Fuchu License Examination Center to update their driver’s license and received leaflets including a message prompting organ donation registration and the questionnaire. Of the participants who received leaflets, 3224 respondents provided complete responses to the questionnaire (valid response rate: 42.3%). Subsequently, a questionnaire survey was conducted to assess the participants’ willingness to register for organ donation. A control condition and the following types of messages were used: peer-framed, gain-framed, loss-framed, reciprocity-framed, and peer + reciprocity-framed. Results. The reciprocity message emerged as a significant predictor of increase in immediate decision response. The loss-framed message was a significant predictor of decrease in no intention to register. Conclusions. This study found that reciprocity and loss-framed messages promoted the readiness to register for organ donation among individuals from a Japanese urban area. Mandatory distribution of prompt messages at every driver’s license centers in Japan would be recommended.
Advocacy: the cornerstone of cancer survivorship.

PURPOSE This article describes a cancer-related advocacy skill set that can be acquired through a learning process. OVERVIEW Cancer survivorship is a process rather than a stage or time point, and it involves a continuum of events from diagnosis onward. There exists little consensus about what underlying processes explain different levels of long term functioning, but skills necessary for positive adaptation to cancer have been identified from both the professional literature and from the rich experiences of cancer survivors. CLINICAL IMPLICATIONS Healthcare practitioners need to be more creative and assertive in fostering consumer empowerment and should incorporate advocacy training into care plans. Strategies that emphasize personal competency and increase self-advocacy capabilities enable patients to make the best possible decisions for themselves regarding their cancer care. In addition, oncology practitioners must become informed advocacy partners with their patients in the public debate about healthcare and cancer care delivery.
Practical Guides for Data Retrieval in Deep Web Crawling

Deep web crawling refers to the process of collecting documents that have been organized into a data source and can only be retrieved via a search interface. This is often achieved by sending different queries to the search interface. Dealing with the difficulty in selecting suitable set of queries, this crawling process can be implemented with stepwise refinement: documents are retrieved step by step, while in each step, we adapt the query selection to our accumulated knowledge obtained from the documents downloaded in the previous steps. However, it takes much of our time and effort to download the documents and learn from the resulting sample in order to improve the query selection. Here we propose a cost-effective, data-driven method for stepping the adaptive crawling of the deep web. Through empirical study, we explore the criteria in setting the lengths of the steps to best balance the trade-off between the sample updating cost and the improved quality of the selected queries. Derived from four existing data sets typically used for deep web crawling, such criteria provide practical guidelines for cost-effective stepwise refinement in iterative document retrieval.
EXAMINING AN INFLUENTIAL FACTOR MEDIATING PERFORMANCE IN TOURISM

This study explores the impact of market orientation on business performance for small and medium enterprises in the tourism industry in Thailand. The associations among market orientation, innovation, and business performance are investigated with an emphasis on the extent to which market orientation and innovation affect business performance. Small and medium hotels located in the Bangkok metropolitan region in Thailand were selected as sample for data collection. A quantitative approach and a structural-direct questionnaire survey were adopted. Of 400 questionnaires distributed to chief decision-makers of small and medium hotels, 155 of the returned questionnaires were usable. Among the small and medium hotels sampled, nearly 60% were small-sized hotels, whereas 40% were mediumsized hotels. The majority of hotels in the sample had been in operation for approximately 10 years. Structural Equation Modelling (SEM) with AMOS was used for data analysis. The results suggest that intelligence generation, intelligence dissemination and responsiveness load significantly into the construct of market orientation. Findings also suggest that market orientation does not have a significant direct effect on business performance for small and medium hotels. However, the effect of market orientation is apparent when the mediating role of innovation is acknowledged. Research limitations and future studies are also addressed.
How Good Are Edge Boxes, Really?

Image region proposals are now commonly placed with the current object detection algorithms to provide an efficient technique to locate object regions. The image region proposal algorithm, Edge Boxes [7] is evaluated on the NYU2 dataset [4] and compared with the optimal parameters from a random parameter search. Edge Boxes performance in the cluttered, low resolution images of the NYU2 dataset, commonly encountered in robotics is shown. While comparisons between region proposals has been performed, few have viewed them as a technique that can be optimised or fine-tuned. The most two influential variables to refine controlled the step size of the region search and the candidate box density. It was found that the default parameters were among the worst for object recall, while the new refined parameters revealed increased recall without sacrificing computation time.
Humidification–Dehumidification (HDH) Desalination System with Air-Cooling Condenser and Cellulose Evaporative Pad

This paper presents a humidification–dehumidification (HDH) desalination system with an air-cooling condenser. Seawater in copper tubes is usually used in a condenser, but it has shown the drawbacks of pipe erosion, high cost of the copper material, etc. If air could be used as the cooling medium, it could not only avoid the above drawbacks but also allow much more flexible structure design of condensers, although the challenge is whether the air-cooing condenser can provide as much cooling capability as water cooling condensers. There is no previous work that uses air as cooling medium in a condenser of a HDH desalination system to the best of our knowledge. In this paper we designed a unique air-cooling condenser that was composed of closely packed hollow polycarbonate (PC) boards. The structure was designed to create large surface area of 13.5 m2 with the volume of only 0.1 m3. The 0.2 mm thin thickness of the material helped to reduce the thermal resistance between the warm humid air and cooling air. A fan was used to suck the ambient air in and out of the condenser as an open system to the environment. Results show that the air-cooling condenser could provide high cooling capability to produce fresh water efficiently. Meanwhile, cellulous pad material was used in the humidifier to enhance the evaporative process. A maximum productivity of 129 kg/day was achieved using the humidifier with a 0.0525 m3 cellulous pad with a water temperature of 49.5 °C. The maximum gained output ratio (GOR) was 0.53, and the maximum coefficient of performance (COP) was 20.7 for waste heat recovery. It was found that the system performance was compromised as the ambient temperature increased due to the increased temperature of cooling air; however, such an effect could be compensated by increasing the volume of the condenser.
Lexicalized Reasoning about Actions

The paper argues for the use of lexicalized grammars, speciﬁcally Combinatory Categorial Gram-mars (CCGs), to direct both recognition and generation problems in planning domains. It reviews previous work on using CCGs for plan recognition and then outlines how the same grammars can be used to direct planning. It does this as part of a larger program to establish and leverage linkages between reasoning about action and language understanding
Self-discrepancy Theory and Body Image Disturbance : Does the " Can Self ' Matter ?

The relevance of self-discrepancy theory for understanding body dissatisfaction, body size distortion, and negative affect was explored. Actual:ideal discrepancies are those between the attributes an individual believes he or she actually possesses and those he or she would ideally hope to possess. The pattern of self-beliefs in which a person believes that he or she can reach his or her ideal standards but is not actually doing so is known in the self-discrepancy framework as unfulfilled positive potential (UFPP). Both actual:ideal discrepancies and UFPP have been found to relate to dejection-related emotions. Whereas previous research has examined actual:ideal self-discrepancies in an effort to explain body image disturbance and eating disorder symptoms, the influence ofUFPP on body image disturbance has not been clearly addressed. This study seeks to understand whether UFPP in the domain of body image is associated with greater body image disturbance than that associated with actual:ideal body-image discrepancies without the added beliefthat the person can meet the ideal standard. Male and female undergraduates (N = 222) completed measures of self-discrepancy, body-image discrepancy, body dissatisfaction, body size distortion, depression, and anxiety. Self-discrepancies and body-image
Let's be Pragmatic: Research in Information Systems with Relevance and Rigor

Pragmatism can be defined as a doctrine that considers things from a practical point of view. Pragmatism preaches that action and practical relevance should be the key points of scientific research. The pragmatic paradigm has been presented as a paradigmatic alternative of positivism and interpretivism, enabling the solution of inherent problems of dominant paradigms, the positivism and interpretivism. The present article presents, from a bibliographical survey, the pragmatic paradigm, making a comparison with other paradigms, as well as the use of quantitative, qualitative and mixed methods, from a perspective of practical relevance with methodological rigor.