Miracle-dz/UniFAR-FTUs huggingface dataset:
The clinical importance of acquired abnormalities of platelet function.

ACQUIRED abnormalities of platelet function are very common. Platelet function, as assessed by in vitro studies or the bleeding-time test, is affected by a vast number of drugs, common foods, vitamins, and spices; by systemic conditions such as chronic renal disease and surgery requiring cardiopulmonary bypass; and by hematologic disorders such as myeloproliferative and lymphoproliferative diseases, dysproteinemias, and the presence of antiplatelet antibodies. The possibility that these abnormalities may underlie an increased risk of bleeding is an important issue when bleeding occurs without a clear cause or when invasive procedures are required. However, the clinical importance of platelet dysfunction is .
Methyl jasmonate influence on silymarin production and plant stress responses in Silybum marianum hairy root cultures in a bioreactor

In this article our aim was to evaluate mass cultivation of S. marianum hairy roots in a bioreactor to produce silymarin. The effects of methyl jasmonate (MJ) elicitation on the accumulation of silymarin and the extent of the MJ-induced oxidative damage were investigated in bioreactor hairy root cultures of S. marianum. The growth rate of the bioreactor hairy root cultures was higher than that of those in a shake flask after 3 weeks. Silymarin accumulation was increased from 0.13 mg g−1 DW in non-treated hairy roots to 0.22 mg g−1 DW in hairy roots 72 h after 100 µM MJ treatment. Guaiacol peroxidase and ascorbate peroxidase were activated by MJ 72 h after treatment, being 3.2- and 1.3-fold higher, respectively, than that of the control. An increase in enzymatic activity suggests increased scavenging of reactive oxygen species, indicating the tolerance to MJ stress. These results suggest that MJ elicitation is beneficial for silymarin production using bioreactor hairy root cultures.
The Quality of Reporting of Health Informatics Evaluation Studies: A Pilot Study

The quality of reporting of evaluations in Health Informatics is considered to be open for improvement. STARE-HI provides guidance for improved reporting. This study aims at establishing the quality of reporting prior to dissemination of STARE-HI. All evaluation papers in three leading Medical Informatics Journals published in 2005 have been assessed with the aid of STARE-HI. A total of 48 papers have been analysed with respect to title, abstract, keywords and study context. Main results indicate that the type of study is seldom reported in the title, that the structured abstract contains more information than an unstructured abstract, that important keywords are often forgotten. Also important information about the system assessed is often not mentioned explicitly. Our conclusion is that there is room for improvement in the reporting of evaluations in health informatics. STARE-HI can be helpful in suggesting a structure for evaluation papers in Health Informatics and issues that should be included in such papers.
Lessons learned from the intersection of two frequent monogenic disorders: the Marfan syndrome and autosomal dominant polycystic kidney disease

Aortic aneurysms, which lead to aortic dissections and ruptures if left untreated, are among the most life threatening forms of cardiovascular disease. Thoracic aortic aneurysm is a prominent clinical feature of several hereditary connective tissue disorders, including Marfan syndrome (MFS). MFS is caused by mutations in FBN1 , which encodes fibrillin-1, an important extracellular matrix protein. Through the study of MFS mouse models and diseases related to MFS, it became clear that dysregulated TGF-β signaling contributes significantly to the pathogenesis of thoracic aortic aneurysms. Thoracic aortic and other aneurysms do also occur in autosomal dominant polycystic kidney disease (ADPKD). Mutations in PKD1 or PKD2 are responsible for ADPKD. The function of the polycystins, the proteins encoded by these two genes, is not clear yet, but an upregulation of TGF-β signaling has also been suggested as a pathogenetic mechanism. Although the main manifestation of ADPKD consists of renal cysts, a clear cardiovascular involvement with aneurysm formation has been demonstrated. Vice versa , kidney cysts have been observed in MFS. This clinical overlap suggests a mechanistic link between ADPKD and MFS. This link provides interesting opportunities for investigations on the pathogenic mechanisms of both diseases, more in particular the mechanisms leading to formation of thoracic aortic aneurysms.
Experimental study on the production of diesel-like fuel from waste high density polyethylene via non-catalytic pyrolysis

Plastics have become an indispensable part of our daily life. Due to its non biodegradable nature it cannot be easily disposed off. Pyrolysis is a tertiary recycling method which can convert plastics into valuable petroleum resources. In this work, pyrolysis of waste high density polyethylene (HDPE) plastic was carried out in a fixed bed reactor heated for a final temperature of 500°C under a heating rate of 10°C/min. Direct pyrolysis led to wax production while a two step pyrolysis (setup 1) led to the production of 32.7% liquid and 65.3% gas. Thus a setup with reflux (setup 2) was designed and the liquid yield increased to 78.2%. The liquid fractions obtained were analyzed for composition using a gas chromatograph coupled to a Mass spectrometer and a flame ionization detector (GC-MS-FID). Specific diesel-like fuel production, as reported to HDPE mass, with setup 2 was estimated to be 2.3 times higher than setup 1 The physical properties of the pyrolytic oil (viscosity, density) were found to be lower than that of diesel fuel due to the presence of light compounds.
Wideband Monopole-Like Radiation Pattern Circular Patch Antenna With High Gain and Low Cross-Polarization

A wideband, high gain, low cross-polarization circular patch antenna with linear polarization and monopole-like radiation pattern is proposed for wireless communication systems. The impedance bandwidth (|S11| <; -10 dB) of 36.5% (4.25-6.15 GHz) is achieved at the central frequency of 5.20 GHz. The simulated and measured peak gains are 9.7 and 9.1 dBi, respectively. A good agreement is achieved between the simulated and measured results.
Coffee, green tea, black tea and oolong tea consumption and risk of mortality from cardiovascular disease in Japanese men and women

Background The effects of coffee and green, black and oolong teas and caffeine intake on cardiovascular disease (CVD) mortality have not been well defined in Asian countries. Methods To examine the relationship between the consumption of these beverages and risk of mortality from CVD, 76 979 individuals aged 40–79 years free of stroke, coronary heart disease (CHD) and cancer at entry were prospectively followed. The daily consumption of beverages was assessed by questionnaires. Results 1362 deaths were documented from strokes and 650 deaths from CHD after 1 010 787 person-years of follow-up. Compared with non-drinkers of coffee, the multivariable HR and 95% CI for those drinking 1–6 cups/week, 1–2 cups/day and ≥3 cups/day were 0.78 (0.50 to 1.20), 0.67 (0.47 to 0.96) and 0.45 (0.17 to 0.87) for strokes among men (p=0.009 for trend). Compared with non-drinkers of green tea, the multivariable HR for those drinking 1–6 cups/week, 1–2 cups/day, 3–5 cups/day and ≥6 cups/day were 0.34 (0.06–1.75), 0.28 (0.07–1.11), 0.39 (0.18–0.85) and 0.42 (0.17–0.88) for CHD among women (p=0.038 for trend). As for oolong tea, the multivariable HR of those drinking 1–6 cups/week and ≥1 cups/day were 1.00 (0.65–1.55) and 0.39 (0.17–0.88) for total CVD among men (p=0.049 for trend). Risk reduction for total CVD across categories of caffeine intake was most prominently observed in the second highest quintile, with a 38% lower risk among men and 22% among women. Conclusions Consumption of coffee, green tea and oolong tea and total caffeine intake was associated with a reduced risk of mortality from CVD.
Complete Genome Sequence of the Type Strain of Aeromonas schubertii, ATCC 43700

ABSTRACT We sequenced the complete genome of the type strain of Aeromonas schubertii, ATCC 43700. The full genome sequence of A. schubertii ATCC 43700 is 4,356,858 bp, which encodes 3,842 proteins and contains 110 predicted RNA genes.
Compression Rate Methodology for Pure Empirical Vision Science

This philosophical paper is motivated by two seemingly unrelated observations: first, progress in computer vision has long been hampered by the difficulty of evaluating and comparing techniques. Second, there exists a deep connection between computer vision and image compression: in both cases the goal is to find parsimonious scene descriptions. These observations lead us to propose a new evaluation methodology for computer vision based on large scale image compression. This methodology has significant practical advantages compared to previous evaluation schemes. It permits rigorous quantitative comparisons, allows researchers to take advantage of large image databases, and provides a single framework within which to evaluate many different techniques. Also, the impossibility of data compression in general implies that in order to compress natural image databases, the empirical regularities present in such images must be discovered and exploited. These ideas suggest that systematic progress can be made by following the compression rate methodology, and this progress will translate directly into advances in computer vision. We also argue that the large scale compression perspective is much closer to the natural setting of the learning problem, and that it opens a new door for statistical learning by justifying the construction of highly complex models.
Crystallization Behavior Of Amorphous Terfenol-D Thin Films

The annealing behavior of amorphous terfenol-D thin films is examined in this work. Amorphous thin films were prepared by DC magnetron sputter deposition from alloy targets. Differential scanning calorimetry of these films was performed in the temperature range 100-800/spl deg/C. Based on DSC data annealing experiments were performed at 400, 550, 575, 600 and 650/spl deg/C. X-ray diffraction shows RFe/sub 2/ phase is formed when samples are annealed at 575-600/spl deg/C. Other phases observed are Fe and rare earth oxide.
A Decomposition Approach for Balancing Large-Scale Acyclic Data Flow Graphs

An efficient decomposition technique that provides a more systematic approach in solving the optimal buffer assignment problem of an acyclic data-flow graph (ADFG) with a large number of computational nodes is presented. The buffer assignment problem is formulated as an integer linear optimization problem that can be solved in pseudopolynomial time. However, if the size of an ADFG increases, then integer linear constraint equations may grow exponentially, making the optimization problem more intractable. The decomposition approach utilizes the critical path concept to decompose a directed ADFG into a set of connected subgraphs, and the integer linear optimization technique can be used to solve the buffer assignment problem in each subgraph. Thus, a large-scale integer linear optimization problem is divided into a number of smaller-scale subproblems, each of which can be easily solved in pseudopolynomial time. Examples are given to illustrate the proposed decomposition technique. >
FairGV: Fair and Fast GPU Virtualization

Increasingly high performance computing (HPC) application developers are opting to use cloud resources due to higher availability. Virtualized GPUs would be an obvious and attractive option for HPC application developers using cloud hosting services. Unfortunately, existing GPU virtualization software is not ready to address fairness, utilization, and performance limitations associated with consolidating mixed HPC workloads. This paper presents FairGV, a radically redesigned GPU virtualization system that achieves system-wide weighted fair sharing and strong performance isolation in mixed workloads that use GPUs with variable degrees of intensity. To achieve its objectives, FairGV introduces a trap-less GPU processing architecture, a new fair queuing method integrated with work-conserving and GPU-centric coscheduling polices, and a collaborative scheduling method for non-preemptive GPUs. Our prototype implementation achieves near ideal fairness (<inline-formula><tex-math notation="LaTeX">$\geq 0.97$</tex-math><alternatives> <inline-graphic xlink:href="nikolopoulos-ieq1-2717908.gif"/></alternatives></inline-formula> Min-Max Ratio) with little performance degradation (<inline-formula><tex-math notation="LaTeX">$\leq 1.02$</tex-math><alternatives> <inline-graphic xlink:href="nikolopoulos-ieq2-2717908.gif"/></alternatives></inline-formula> aggregated overhead) in a range of mixed HPC workloads that leverage GPUs.
A gene order database of plastid genomes

A gene order database of 32 completely sequenced plastid genomes was developed. The data structure is formally identical to that of the feature tables in the major GenBank/EMBL/DDBJ databases. The quality of annotations was largely improved. A normalizing gene-labeling system across the complete plastid genomes was developed so that comparative studies are made available without having to go back to sequence analysis. Many incorrect coordinates of tRNA-encoding regions found in the major databases were corrected. We attempted to distinctively label tRNA genes with the anticodon sequence CAT, which encodes either the initiator tRNA, elongator tRNA, or Ile-tRNA. The database is available at http://www.rs. noda.tus. ac.jp/~kunisawa.
Thermoelastic waves in an anisotropic infinite plate

An analysis of the propogation of thermoelastic waves in a homogeneous, anisotropic, thermally conducting plate has been presented in the context of the generalized Lord-Shulman theory of thermoelasticity. Three different methods are used in this analysis: two of them are exact and the third is a semianalytic finite element method (SAFE). In our exact analysis, two different approaches are used. The first one, which is applicable to transversely isotropic plate, is based on introducing displacement potential functions, whereas in the second approach, which is applicable to any triclinic material, we rewrite the governing equations and boundary conditions in a matrix form. Finally, in the SAFE method, the plate is discretized along its thickness using N parallel, homogeneous layers, which are perfectly bonded together. Frequency spectrum and dispersion curves are obtained using the three methods and are shown to agree well with each other. The effects of thermal relaxation time and coupling term are also i.
Functional MRI assessment of orofacial articulators: Neural correlates of lip, jaw, larynx, and tongue movements

Compared with complex coordinated orofacial actions, few neuroimaging studies have attempted to determine the shared and distinct neural substrates of supralaryngeal and laryngeal articulatory movements when performed independently. To determine cortical and subcortical regions associated with supralaryngeal motor control, participants produced lip, tongue and jaw movements while undergoing functional magnetic resonance imaging (fMRI). For laryngeal motor activity, participants produced the steady‐state/i/vowel. A sparse temporal sampling acquisition method was used to minimize movement‐related artifacts. Three main findings were observed. First, the four tasks activated a set of largely overlapping, common brain areas: the sensorimotor and premotor cortices, the right inferior frontal gyrus, the supplementary motor area, the left parietal operculum and the adjacent inferior parietal lobule, the basal ganglia and the cerebellum. Second, differences between tasks were restricted to the bilateral auditory cortices and to the left ventrolateral sensorimotor cortex, with greater signal intensity for vowel vocalization. Finally, a dorso‐ventral somatotopic organization of lip, jaw, vocalic/laryngeal, and tongue movements was observed within the primary motor and somatosensory cortices using individual region‐of‐interest (ROI) analyses. These results provide evidence for a core neural network involved in laryngeal and supralaryngeal motor control and further refine the sensorimotor somatotopic organization of orofacial articulators. Hum Brain Mapp 33:2306–2321, 2012. © 2011 Wiley Periodicals, Inc.
Preferences for shared decision making in chronic pain patients compared with patients during a premedication visit

Background: There is some evidence that patients’ outcomes improve if they are involved in shared decision making (SDM). A chronic pain clinic or premedication visit could be adequate settings for the implementation of SDM. So far, the patients’ preference for involvement in decision making and their desire for information have not been tested in anesthesiological settings.
A novel approach for hiding secret data in program files

All large programs and software development projects, irrespective of application, generate a large amount of associated documentation. Documentation is an important part of all types of programs and software. It tells other programmers what the program does and how it works. Documentation helps others and teammates understand your work. In this proposed work, I have designed a method which hides important and secret data into the programs and software document parts with three layers of security. The resultant stego file undoubtedly can be transmitted anywhere using any channel. Experimental results show the feasibility of the proposed methodology.
Down-Modulation of Responses to Type I IFN Upon T Cell Activation1

The immunomodulatory role of type I IFNs (IFN-α/β) in shaping T cell responses has been demonstrated, but the direct effects of IFN on T cells are still poorly characterized. Particularly, because IFN exert an antiproliferative activity, it remains elusive how the clonal expansion of effector T cells can paradoxically occur in the event of an infection when large amounts of IFN are produced. To address this issue, we have studied the effects of type I IFN in an in vitro differentiation model of human primary CD4+ T cells. We found that IFN-α treatment of resting naive T cells delayed their entry into the cell cycle after TCR triggering. Conversely, the ongoing expansion of effector T cells was not inhibited by the presence of IFN. Moreover, activated T cells showed a significantly reduced induction of IFN-sensitive genes, as compared with naive precursors, and this decline occurred independently of subset-specific polarization. The residual type I IFN response measured in activated T cells was found sufficient to inhibit replication of the vesicular stomatitis virus. Our data suggest that the activation of T lymphocytes includes regulatory processes that restrain the transcriptional response to IFN and allow the proliferation of effector cells in the presence of this cytokine.
FGF Ligand Family mRNA Expression Profile for Mouse Preimplantation Embryos, Early Gestation Human Placenta, and Mouse Trophoblast Stem Cells

Signaling by fibroblast growth factor (FGF) is essential is for trophoblast stem (TS) cells and preimplantation embryos. FGF4 provides essential signaling, but the expression of the complete set of 23 FGF family members has not been analyzed. Here, semi‐quantitative RT‐PCR and microarray analyses were used to define expression of all FGF ligand mRNA. RT‐PCR was done for developmentally important FGF subfamilies, FGF10/FGF22 and FGF8/FGF17/FGF18 as well as FGF11. FGF4 and FGF18 are detected at highest levels by RT‐PCR and microarrays. FGF10 was detected at low levels in both assays. FGF11 was detected at moderate levels by microarray, but not by RT‐PCR. FGF17 was detected at low levels by array and moderate levels by RT‐PCR. FGF8 and FGF22 were detected by RT‐PCR, but not by microarrays during late cleavage divisions. FGF8, FGF5, and FGF9 were detected in the oocyte by microarray. FGF2, FGF3, and FGF7 were not detected by RT‐PCR or microarrays and FGF13, FGF14, and FGF23 were not detected by microarray. Since a major role of FGF is to maintain TS cells, we tested human and mouse placental cell lines and early gestation human placenta for expression of FGF ligands. Expression in mouse TS cells was compared with preimplantation embryos, and human placental cell line expression was compared with human placenta, to infer which ligands are expressed in placental lineage vs. other cell lineages. The data suggest that human and mouse placenta share FGF18 and its high expression suggests preimplantation and early placental function. Mol. Reprod. Dev. © 2006 Wiley‐Liss, Inc.
Converting Handwritten Mathematical Expressions into LATEX

Recently there has been an increase in the usage of digital documents in academia. Although there has been work done to convert physical documents into their digital counterparts, most of it is limited to natural language. Digitizing mathematical expressions is becoming more necessary such as when submitting a problem set or writing a research paper, but many recognition systems fail to accurately convert special mathematical symbols such as μ or φ since they are not generally in natural language documents. Additionally, natural text converters fail to handle complex mathematical structures and relationships (e.g. fractions, summations, subscripts, etc.).
Acute generalized skin eruption due to adalimumab: report of two cases

Editor Adalimumab (Humira®, Abbott, Abbott Park, IL, USA) is a human recombinant immunoglobulin G1 monoclonal antibody specific for human TNFα . It has been approved for use in the treatment of active rheumatoid arthritis and psoriatic arthritis. 1,2 We describe two patients who presented with a generalized erythematous skin rash after the first doses of adalimumab, requiring discontinuation of treatment. A 41-year-old, female patient with a 5-year history of rheumatoid arthritis was prescribed subcutaneous etanercept, 25 mg twice a week. She also took lephlunomide 20 mg a day, with total remission of rheumatoid arthritis. One year later, after an acute episode of arthritis in the left ankle, her treatment was changed to subcutaneous adalimumab (Humira®) 40 mg once a week. Seven days after beginning this new treatment, the patient came to our dermatology service with a pruritic, erythematous, macular-papular rash on the thorax and limbs (fig. 1). Treatment with topical corticosteroids and oral antihistaminics was started, although it was decided to continue adalimumab. The biopsy showed a periadnexal and medialsuperficial perivascular dermatitis, suggesting an episode of drug skin eruption. After 10 days the rash and pruritus worsened, even with medical treatment with topical corticosteriods and oral antihistaminics, and adalimumab was discontinued. The clinical symptoms resolved in 10 days. A 38-year-old, female patient had psoriatic arthritis. Treatment with metrothexate 15 mg a week and folic acid 5 mg a week was begun. This treatment was continued for 2 years but, as clinical response was poor, subcutaneous adalimumab (Humira®) 40 mg once a week was started in 2005. Seven days after treatment had started the patient came to our service with a very pruritic, macular-papular, erythematous rash that had appeared 2 days earlier on the thorax and limbs. The case was managed as a generalized skin rash due to adalimumab; treatment with topical corticosteroids and oral antihistaminics was initiated and adalimumab was discontinued. The biopsy report stated a periadnexal and medial-superficial perivascular dermatitis suggesting a drug skin eruption episode. The patient returned to the dermatology service 7 days later, by which time the symptoms had resolved. Adalimumab is the first fully human-derived recombinant antibody against tumour necrosis factorα (TNFα ). It has a low immunogenicity potential and is administered by intravenous or subcutaneous injection. It binds to TNFα , preventing this cytokine from reaching the p55 and p75 receptors. Pharmacological blockade of TNFα has been a highly effective approach to treating several immunologically mediated diseases, including rheumatoid arthritis, psoriatic arthritis and severe psoriasis. 3