Miracle-dz/UniFAR-FTUs huggingface dataset:
Inhibition of Cdk5 Ameliorates Skeletal Bone Loss in Glucocorticoid-Treated Mice

Glucocorticoids (GCs) are widely used to treat inflammatory diseases. However, their long-term use leads to glucocorticoid-induced osteoporosis, increasing morbidity and mortality. Both anabolic and anti-resorptive drugs are used to counteract GC-induced bone loss, however, they are expensive and/or have major side effects. Therefore, identifying new targets for cost-effective, small-molecule inhibitors is essential. We recently identified cyclin-dependent kinase 5 (Cdk5) as a suppressor of osteoblast differentiation and showed that its inhibition with roscovitine promoted osteoblastogenesis, thus improving the skeletal bone mass and fracture healing. Here, we assessed whether Cdk5 knockdown or inhibition could also reverse the GC-mediated suppression of osteoblast differentiation, bone loss, and fracture healing. We first demonstrated that Cdk5 silencing abolished the dexamethasone (Dex)-induced downregulation of alkaline phosphatase (Alp) activity, osteoblast-specific marker gene expression (Runx2, Sp7, Alpl, and Bglap), and mineralization. Similarly, Cdk5 inhibition rescued Dex-induced suppression of Alp activity. We further demonstrated that Cdk5 inhibition reversed prednisolone (Pred)-induced bone loss in mice, due to reduced osteoclastogenesis rather than improved osteoblastogenesis. Moreover, we revealed that Cdk5 inhibition failed to improve Pred-mediated impaired fracture healing. Taken together, we demonstrated that Cdk5 inhibition with roscovitine ameliorated GC-mediated bone loss but did not reverse GC-induced compromised fracture healing in mice.
Binder Influence on the Water Adsorption Uptake of Silica Gel

The heat transfer rate of an adsorbent embedded heat exchanger can be significantly improved by as much as three folds using powder adsorbent coated by binder on the fin surfaces of exchangers. The overall performance of such exchangers in an adsorption chiller, however, is determined both by the heat transfer and adsorption mass transport phenomena, which are also highly interlaced in the chiller operations. If a severe suppression on the latter is observed as a result of the binder, the heat exchanger may eventually underperform. This work evaluates the overall effect of the binder on the mass transport. It focuses on a common adsorbent-adsorbate pair utilized in the chiller, i.e. silica gel type 3A-water. A hydroxyethyl cellulose (HEC) is used as the binder. Experiment is conducted to measure the water equilibrium uptake of the pure and binder added silica gel at various temperatures. Based on the results, the net influence of the binder on the water uptake rate in the adsorption heat transfer process is determined.
Is It Just Face Blindness? Exploring Developmental Comorbidity in Individuals with Self-Reported Developmental Prosopagnosia

Developmental prosopagnosia (DP)—or ‘face blindness’—refers to life-long problems with facial recognition in the absence of brain injury. We know that neurodevelopmental disorders tend to co-occur, and this study aims to explore if individuals with self-reported DP also report indications of other neurodevelopmental disorders, deficits, or conditions (developmental comorbidity). In total, 115 individuals with self-reported DP participated in this online cross-sectional survey. Face recognition impairment was measured with a validated self-report instrument. Indications of difficulties with navigation, math, reading, or spelling were measured with a tailored questionnaire using items from published sources. Additional diagnoses were measured with direct questions. We also included open-ended questions about cognitive strengths and difficulties. Results: Overall, 57% reported at minimum one developmental comorbidity of interest, with most reflecting specific cognitive impairment (e.g., in memory or object recognition) rather than diagnostic categories (e.g., ADHD, dyslexia). Interestingly, many participants reported cognitive skills or strengths within the same domains that others reported impairment, indicating a diverse pattern of cognitive strengths and difficulties in this sample. The frequency and diversity of self-reported developmental comorbidity suggests that face recognition could be important to consider in future investigations of neurodevelopmental comorbidity patterns.
The Use of Counseling Skills Within Evaluative Contexts

Abstract The use of non-therapeutic counseling skills within evaluative contexts can be of great utility, particularly when lack of trust can lead to challenges in design, data collection, analysis, and contextualization. Because counselors and program evaluators share commonalities in their competencies, counselors can leverage their mastery of interpersonal skills to facilitate a depth of connection and understanding among stakeholders that supports evaluation validity. This article describes how counselors’ training and experiences focused on using empathic communication, becoming aware of and accounting for bias, broaching differences in identities and sensitive conversations with clients, and connecting with clients using basic attending skills can ground evaluation activities in ways that promote representation of experiences and utility of findings.
Thermodynamics of viscous dark energy for the late future time universe

In this work we explore the thermodynamic aspects of dark energy for late future time universe in two different scenarios: as a perfect fluid with constant and variable equation of state parameter; and as dissipative fluid described by a barotropic equation of state with bulk viscosity in the framework of the Eckart theory and the full Israel-Stewart theory.We explore cosmological solutions for a flat, homogeneous and isotropic universe; and we assume the late future time behavior when the dark energy dominates the cosmic evolution.When modeled as a perfect fluid with a dynamical equation of state, $p=w(a)\rho$, the dark energy has an energy density, temperature and entropy well defined and an interesting result is that there is no entropy production even though been dynamical. For dissipative dark energy, in the Eckart theory two cases are studied: $\xi=const. $ and $\xi =(\beta/\sqrt{3}) \rho^{1/2}$; it is found that the entropy grows exponentially for the first case and as a power-law for the second.In the Israel-Stewart theory we consider a $\xi =\xi_0 \rho^{1/2}$ and a relaxation time $\tau = \xi/\rho$; an analytical Big Rip solution is obtained with a power-law entropy.In all cases is obtained a power-law relation between temperature and energy density.In order to maintain the second law of thermodynamics theoretical constraints for the equation of state are found in the different dark energy models studied.A barotropic dark fluid with $w<-1$ is thermodynamically difficult to support, but the overall effect of bulk viscosity in certain cases allows a phantom regime without thermodynamic anomalies.
Development Characteristics and Causes of a Fatal Landslide Occurred in Shuicheng, Guizhou Province, China

At about 20:40 on 23 July 2019, a high-level and long-runout landslide occurred in Jichang Town, Shuicheng County, Guizhou Province (hereafter called the Shuicheng landslide). This slope failure was highly devastating, and most of the local residents were severely affected, including 52 dead or missing. Based on the information provided by field investigations, drilling boreholes, and Google Earth, we describe the landform and stratigraphy characteristics of the Shuicheng landslide in this study. Additionally, the dataset of 1158 ancient landslides near the Shuicheng landslide is obtained by Google Earth and ArcGIS, including their morphological scales and spatial distribution characteristics, to analyze the landslide development preference in this region. Furthermore, the causes of the Shuicheng landslide are discussed by analyzing the effects of active tectonic activities on the broken basalt and the steep terrain, as well as the trigger action of continuous heavy rainfall. Finally, a previous empirical prediction formula of sliding distance is verified by the Shuicheng landslide parameters and is applied into the width range calculation of the ancient landslide risk zones, which is a kind of risk source for future landslides. The result indicates the area up to ≈3500 m away from the landslide risk source should be concerned during engineering construction in the study area. This study provides significant scientific guidance for the risk management of potential landslide hazards in this area.
Indigenous metal melting and casting in Southern Africa

Metal casting involves melting a metal charge in a crucible, and pouring it into a mould with a predetermined shape. This is not generally thought of as an important aspect of metal working in pre-European southern Africa, but it played a role in the second millennium AD for producing ingots, blanks for rings and bangles, and rare objects of probable ritual significance. Casting was restricted to the non-ferrous metals, like copper and tin and their alloys, because indigenous bloomery iron technology could not produce large quantities of molten iron for casting. As far as we know, gold was not cast into moulds, although beads were fashioned by punching holes through spherical globules produced by melting. This paper presents metallographic and chemical analyses of the various products of metal casting, and summarizes what is known about indigenous casting technology in southern Africa.
Online Temperature Identification Strategy for Position Sensorless PMSM Drives With Position Error Adaptive Compensation

For the position sensorless permanent magnet synchronous motor (PMSM) drive system, the online identification of temperature is of great significance for safe operation. Generally, the motor temperature can be obtained directly from the stator resistance, the identification of which is, however, affected by the position estimation error of sensorless control. In order to deal with this problem, a stator temperature identification method for the interior PMSM is proposed with the position error adaptive compensation. The influence of position error on the stator resistance and temperature identification is analyzed and then compensated based on the minimum current vector online tracking (MCVOT) scheme for improving the identification precision. For further improving the accuracy and the convergence rate of MCVOT, a current vector angle tracking strategy based on the adaptive variable tracking step value is adopted in the rotating reference frame. The validity of the proposed method is verified on two experimental platforms.
(RE) visiting cooperative teaching learning: A study to assess the effectiveness of its application to arab nursing students, at Oman Nursing Institute, Muscat

Despite of widespread research information representing that cooperative teaching and learning improves level of academic performance, the improvement of communication skills, critical thinking skills and good group cohesion at all levels in their education, cooperative learning as an innovative teaching method, is still underutilized in the nursing curriculum. A cooperative teaching learning method was introduced in the Adult Health Nursing subject for the 162 second year General Nursing Diploma students through Quasi Experimental one group post test design. The 3 cooperative teaching methods namely Jig saw Puzzle, Partners and Team Pair Solo was imparted to the students. The quiz was conducted after each method at one week interval. Students were asked feedback about the merits and demerits of this method by completing the questionnaire. The result shows that this method progressively contributes to the student's academic scores. In addition, the merits and demerits tool reveals that the students “enjoyed the method; this method was very creative, motivating, interesting, beneficial and helps them in critical thinking process. ” They also revealed this pedagogical method was student friendly and make their knowledge permanent. Therefore, it can be broadly concluded that this cooperative teaching method is beneficial and can enhance the overall academic achievement of the students in nursing courses.
Aluminium-wood antenna

The objective of this work is to develop a low cost ground microstation for the reception of Worldspace satellite signals. Among the antennas operating over the frequency bands used for satellite reception, microstrip antennas have been selected because of their small size and the possibility of cheap manufacture. Wood and aluminium have been used to manufacture our antenna. Printed circuit processes are replaced by a simple gluing procedure. Since the patch antenna is made out of aluminium, copper wires and connectors cannot be directly soldered to it. This problem is avoided by feeding the patch through a slot in the ground plane and thus mimicking a SSFIP type antenna. For the wood, locally available tree species were first tested for suitability as microstrip antenna substrates. Two measurement methods were used at microwave frequencies: the waveguide technique and the open resonator technique. Successful receiving tests of Afristar Worldspace satellite radio were carried out.
Combination of an inject-and-transfer system for serial femtosecond crystallography

Serial femtosecond crystallography (SFX) enables the determination of the room-temperature crystal structure of macromolecules without causing radiation damage and provides time-resolved molecular dynamics by pump-probe experiments. In the SFX experiment, the injector-based sample delivery method continuously provides fresh crystals to X-rays, and the fixed-target scanning method can be programmed to move the crystals to the desired location. This study introduces a combination of the inject-and-transfer system (BITS) method for sample delivery for SFX experiments, a hybrid injection, and a fixed-target scanning method. BITS allows solution samples to be reliably deposited on an ultraviolet ozone (UVO)-treaed polyimide films at flow rates as low as 1 nl/min. In application of BITS in SFX experiment, the lysozyme crystal samples were embedded in a viscous lard medium and injected at a 50–100 nl/min flow rate through a syringe needle onto an UVO-treated polyimide film mounted on a fixed-target scan stage. The deposited crystal sample on film were raster scanned to XFEL by motion stage in the horizontal and vertical directions. Using this method, we successfully determined the room-temperature structure of lysozyme at 2.1 Å resolution. This method can be applied to the SFX experiments.
Design and Simulation of Ground Station (GS) Television Channel (TV CH) Group

The Multiple Channel per Carrier (MCPC) is considered an efficient alternative when used in Ground Station (GS) TV channel stations as it accommodate multiple channel on a limited frequency range. The MCPC technique has been widely used worldwide due to its efficiency. The MCPC technique offers exemplary performance over the traditionally Single channel Per Carrier (SCPC) when considering system accuracy, time, and cost. In this study, the MCPC static mode technique has been investigated using MATLAB tool to simulate a four TV CH system. The GS transmitter and receiver components referenced to four explicit points representing the number of channels carried by the satellite. These components have been constructed and observed using Spectrum Analyzer.
Macromolecular Proton Fraction as a Myelin Biomarker: Principles, Validation, and Applications

Macromolecular proton fraction (MPF) is a quantitative MRI parameter describing the magnetization transfer (MT) effect and defined as a relative amount of protons bound to biological macromolecules with restricted molecular motion, which participate in magnetic cross-relaxation with water protons. MPF attracted significant interest during past decade as a biomarker of myelin. The purpose of this mini review is to provide a brief but comprehensive summary of MPF mapping methods, histological validation studies, and MPF applications in neuroscience. Technically, MPF maps can be obtained using a variety of quantitative MT methods. Some of them enable clinically reasonable scan time and resolution. Recent studies demonstrated the feasibility of MPF mapping using standard clinical MRI pulse sequences, thus substantially enhancing the method availability. A number of studies in animal models demonstrated strong correlations between MPF and histological markers of myelin with a minor influence of potential confounders. Histological studies validated the capability of MPF to monitor both demyelination and re-myelination. Clinical applications of MPF have been mainly focused on multiple sclerosis where this method provided new insights into both white and gray matter pathology. Besides, several studies used MPF to investigate myelin role in other neurological and psychiatric conditions. Another promising area of MPF applications is the brain development studies. MPF demonstrated the capabilities to quantitatively characterize the earliest stage of myelination during prenatal brain maturation and protracted myelin development in adolescence. In summary, MPF mapping provides a technically mature and comprehensively validated myelin imaging technology for various preclinical and clinical neuroscience applications.
The western Andes at ~20–22°S: A contribution to the quantification of crustal shortening and kinematics of deformation

The Andes are an emblematic active Cordilleran orogen. It is admitted that mountain-building in the Central Andes at ~20°S started by Late Cretaceous to Early Cenozoic along the subduction margin, and propagated eastward. In general, the structures sustaining the uplift of the West Andean flank are dismissed, and their contribution to mountain-building remains poorly solved. Here, we focus on two sites along the western Andes at 20–22°S, where structures are well exposed. We combine mapping from high-resolution satellite images with field observations and numerical trishear forward modeling to provide quantitative constraints on the kinematic evolution of the western Andes. Our results confirm the existence of two main structures: (1) the Andean Basement Thrust, a west-vergent thrust system placing Andean Paleozoic basement over Mesozoic strata; and (2) a series of west-vergent folds pertaining to the West Andean Fold-and-Thrust-Belt, deforming primarily Mesozoic units. Once restored, we estimate that both structures accommodate together at least ~6–9 km of shortening across the sole ~7–17 km-wide outcropping fold-and-thrust-belt. This multi-kilometric shortening represents only a fraction of the total shortening accommodated along the whole western Andes. The timing of the main deformation recorded in the fold-and-thrust-belt can be bracketed sometime between ~68 and ~29 Ma – and possibly between ~68 and ~44 Ma – from dated folded geological layers, with a subsequent significant slowing-down of shortening rates. Even though negligible when compared to total shortening across the whole orogen, the contribution of the structures of the West Andes has been likely significant at the earliest stages of Andean mountain-building before deformation was transferred eastward.
Harmonizing Graphene Laminate Spacing and Zinc‐Ion Solvated Structure toward Efficient Compact Capacitive Charge Storage

Aqueous Zn‐ion hybrid capacitors (ZIHCs) present prominent potentials in flexible wearable electronics application scenarios due to their inherent high safety and low cost. Simultaneously, volumetric energy density is one of the crucial parameters to determine the lifespan of the wearable electronics, in which lightweight and miniaturization is a cardinal prerequisite for realistic application. In this work, an aqueous ZIHC is constructed by harmonizing interlayer spacing of the laminate graphene film and Zn‐ion solvation structure to improve the electrode space utilization. Laminate graphene film interspacing has been customized in the range of 0.72–0.81 nm via regulating the ratio of crumple graphene mediator, thereby optimizing the transport kinetics of large size hydrated Zn ions. Zn‐ion solvation structure is further tailored by introducing ZnCl2 electrolyte salt to accouple such regulated laminar ionic transport channel. In a result, the thus‐derived ZIHC demonstrates an ultralong cycling lifespan of 100 000 cycles (93.9% capacitance retention), a preeminent volumetric capacitance (235.4 F cm−3), and a remarkable specific area capacitance contribution (Cssa ≈ 72 µF cm−2). Quasi‐solid‐state ZIHC is assembled with ZnCl2 solution‐filled polyacrylamide gel electrolyte to concurrently achieve a superior areal capacitance of 1227 mF cm−2 and great mechanical flexibility toward practical wearable application.
Efficacy of local‐regional treatment plus sorafenib in intermediate‐stage hepatocellular carcinoma patients refractory to transarterial chemoembolization

Sorafenib treatment is suggested for patients with intermediate‐stage hepatocellular carcinoma (HCC) refractory to transarterial chemoembolization (TACE). This study aimed to study if combining local‐regional treatment with sorafenib adds benefit to patients who had tumor progression after three sessions of TACE within 12 months. We retrospectively analyzed the treatment outcomes of sorafenib alone and combined treatment of sorafenib and local‐regional therapies in intermediate‐stage HCC patients after using inverse probability of treatment weighting (IPTW). Forty‐nine patients were enrolled; 28 patients were treated with sorafenib alone, whereas 21 patients received TACE or radiofrequency ablation (RFA) in addition to sorafenib. After IPTW, the two groups were well‐balanced for most baseline characteristics. The overall response rate (ORR) and disease control rate (DCR) were significantly higher in the sorafenib‐combination group than the sorafenib‐alone group (ORR: 41.3% vs 10.0%, P = .001; DCR: 44.6% vs 22.1%). The PFS was also significantly longer in the patients of the sorafenib‐combination group than the alone group (median 5.3 vs 3.0 months, HR, 0.55; 95% CI, 0.35‐0.88). The risk of extrahepatic metastases was significantly lower in the sorafenib‐combination group (HR, 0.04; 95% CI, 0.01‐0.50). The incidence of adverse events was comparable between sorafenib‐combination and sorafenib‐alone groups. Loco‐regional therapy may be still able to exert additional survival benefit to patients taking sorafenib for TACE‐refractory intermediate‐stage HCC showing a better PFS and lower risk of extrahepatic metastases without causing significant liver dysfunction. Further investigations to identify patients who will be more likely to benefit from the combination of sorafenib with local‐regional therapy are needed.
Terminal sliding mode control of a micro quadrotor aircraft

To solve the attitude stabilization and velocity tracking problems of a micro quadrotor aircraft under the nonlinear dynamic model,the controller design using global fast terminal sliding mode control(TSMC) method was studied.By introducing equivalent control inputs,the three channels of aircraft attitude control were decoupled and the TSMC attitude stabilization controllers were designed independently.For velocity tracking and altitude tracking issues,a coupling controller was designed,which was established according to the requirement of altitude hold and can guarantee velocity tracking performance.The simulations of attitude stabilization and velocity tracking showed the performance of the designed controllers.