Miracle-dz/UniFAR-FTUs huggingface dataset:
Tissue Engineering of Esophagus Tissue Engineering of Esophagus

The incidences of esophageal diseases like atresia, tracheoesophageal fistula, esophagi ‐ tis, and even carcinoma rise rapidly worldwide. Traditional therapies such as surgery, chemotherapy, or/and radiotherapy, etc. always meet problems, leading to deterioration of the patients’ life quality and sometimes the reduced survival rate. Tissue‐engineered esophagus, a novel biologic substitute with tissue architecture and bio‐functions, has been believed to be a promising replacement in the future. However, the research of esophageal tissue engineering is still at the early stage. Considerable research has been focused on the issues of developing ideal scaffolds with optimal materials and fabrication methods. The in vivo tests and clinic attempts are being progressed.
Some new methods for Hamilton-Jacobi type nonlinear partial differential equations

I present two recent research directions in this dissertation. The first direction is on the study of the Nonlinear Adjoint Method for Hamilton-Jacobi equations, which was introduced recently by Evans [27]. The main feature of this new method consists of the introduction of an additional equation to derive new information about the solutions of the regularized Hamilton-Jacobi equations. More specifically, we linearize the regularizedHamilton-Jacobi equations first and then introduce the corresponding adjoint equations. Looking at the behavior of the solutions of the adjoint equations and using integration byparts techniques, we can prove new estimates, which could not be obtained by previous techniques.We use the Nonlinear Adjoint Method to study the eikonal-like Hamilton-Jacobi equations [79], and Aubry-Mather theory in the non convex settings [10]. The latter one is based on joint work with Filippo Cagnetti and Diogo Gomes. We are able to relax theconvexity conditions of the Hamiltonians in both situations and achieve some new results.The second direction, based on joint work with Hiroyoshi Mitake [69, 68], concerns the study of the properties of viscosity solutions of weakly coupled systems of Hamilton-Jacobi equations. In particular, we are interested in cell problems, large time behavior, and homogenization results of the solutions, which have not been studied much in the literature.We obtain homogenization results for weakly coupled systems of Hamilton-Jacobi equations with fast switching rates and analyze rigorously the initial layers appearing naturally in the systems. Moreover, some properties of the effective Hamiltonian are also derived.Finally, we study the large time behavior of the solutions of weakly coupled systems of Hamilton-Jacobi equations and prove the results under some specific conditions. The general case is still open up to now.
Control Overhead Minimization In IoT Network and An E ffi cient Clustered IoT (CIoT) Routing Protocol

Internet of Things (IoT) is a novel networking communication field, that the nodes act as physical objects. These objects might be stationary or mobility. Most of the networking communication problems occur due to moving objects rather than the stationary objects. Because of the mobility in IoT networks, an excessive number of control overhead messages is generated. These messages are generated due to frequently exchanging of some control information such as device identity, location information, device mobility, device direction, and others. The most common solutions to similar problems in any flat network is to use clustering techniques. In general, clustering solve partially the problem of generated high control overhead messages. Therefore, many proposed or enhanced Cluster-Based Routing (CBR) protocols trying to solve the shortcoming of the traditional CBR protocols. In CBR protocols, each cluster selects only one device based on some parameters, and we called this device is a LEaDeR (LEDR). The LEDR acts as a coordinator to its associated cluster. Furthermore, the rest of devices that located in the cluster are called Smart DEVices (SDEV). In fact, a problem occurs when the SDEVs and the LEDR exchange their control messages among each other. The exchanging of these messages consumes the available network resources. This article objects to minimize the generated control overhead messages that produced by SDEVs and LEDRs. To solve this problems, we propose the Predictive Generated Hello Messages Algorithm (PGHMA). The PGHMA objects to reduce the amount of HELLO and ADV messages. Also, we proposed a Clustered IoT (CIoT) routing protocol, that applied in clustered topology. The proposed CIoT protocol aims to e ffi ciently propagate the messages between any pair of devices in a grid topology. The CIoT protocol select only one route among a group of candidate routes, the selected route verified and evaluated based on some constraints. Finally, we implement and evaluate our proposed algorithms by comparing it to other related algorithms that published in the literature.
Institutional Knowledge at Singapore Management University Resilient Collaborative Intelligence for Adversarial IoT Environments

—Many IoT networks, including for battleﬁeld deploy- ments, involve the deployment of resource-constrained sensors with varying degrees of redundancy/overlap (i.e., their data streams possess signiﬁcant spatiotemporal correlation). Collaborative intelligence, whereby individual nodes adjust their in- ferencing pipelines to incorporate such correlated observations from other nodes, can improve both inferencing accuracy and performance metrics (such as latency and energy overheads). Using realworld data from a multicamera deployment, we ﬁrst demonstrate the signiﬁcant performance gains (up to 14% increase in accuracy) from such collaborative intelligence, achieved through two different approaches: (a) one involving statistical fusion of outputs from different nodes, and (b) another involving the development of new collaborative deep neural networks (DNNs). We then show that these collaboration-driven perfor- mance gains susceptible to adversarial behavior by one or more nodes, and thus need resilient mechanisms to provide robustness against such malicious behavior. We also introduce an under-development testbed at SMU, speciﬁcally designed to enable real- world experimentation with such collaborative IoT intelligence techniques.
Spectrophotometric Determination of Gemifloxacin Mesylate, Moxifloxacin.HCl and Gatifloxacin Sesquihydrate in Pure and in Pharmaceutical Preparations

IMPLE, rapid and sensitive spectrophotometric method was developed for the determination of gemifloxacin mesylate (GMF), moxifloxacin.HCl (MXF) and gatifloxacin sesquihydrate (GAF) in pure and pharmaceutical preparation. This method is based on ion pair formation reaction between GMF, MXF and GAF and rosebengal indicator in universal buffer of pH 5.The formed ion pair is measured at λ max = 575 nm. All optimum conditions are established. The calibration graphs are rectilinear at concentration ranges 9.71 – 53.40, 8.758 – 52.55 and 8.048– 48.29 μg ml -1 for GMF, MXF and GAF, respectively. The sandell sensitivity (S) = 0.0263 , 0.0244 and 0.0263 μg cm -2 , molar absorptivity = 1.861x 10 4 , 1.835x 10 4 and 1.561x 10 4 L mol -1 cm -1 , correlation coefficient 0.9998 and LOD = 01.90, 1.607 and 1.876 μg ml -1 and LOQ = 05.74, 0.2036 and 5.684 μg ml -1 are calculated for GMF, MXF and GAF, respectively. The values of SD are = 0.0218 - 0.0297, 0.02 -0.0377 and 0.0216 - 0.0282 and RSD are = 0.0554 - 0.3075, 0.0380 -0.4344 and 0.0537 - 0.3497 % for GMF, MXF and GAF. The method is applied for the assay of investigated three drugs in pharmaceutical dosage forms. The results are in good agreement with those obtained by the official methods.
IT-Based Change Resistance in Higher Education

With the transformation from Education 3.0 to Education 4.0, changes in higher education cannot be avoided in various aspects of universities, including in learning technology and methods, as well as the learning targets. Adaptation is essential for the academic and administrative processes in higher education to maintain the continuity of information technology (IT) quality management. Flexibility is one major factor for higher education to maintain sustainability and increase the universities values. However, differences in university conditions can lead to differences in the ability to adopt the concept of flexibility. There are inhibiting factors that cause resistance in adopting IT-based changes, which should be managed using the right strategy. A good management is expected to minimize the cause of resistance so that the flexibility of IT management in universities can be improved. Currently, the discussion of handling resistance focuses on companies and organizations in general. This paper focused specifically on analyzing factors that cause resistance to IT-based changes in universities supported by empirical evidence. The stages of the research consisted of the identification of variables, building survey instruments, data collection, and testing variables. The results show that the variables of financial support, human resources, and management support, simultaneously affecting IT-based change resistance in universities. The simultaneous influence percentage obtained in this study was 79%.
The Biological Effects of (cid:496) -Cyclodextrin on Antithrombotic Activity and Plasma Lipid Metabolism in Rats

The effect of feeding a cyclic oligosaccharide, (cid:496) -cyclodextrin( (cid:496) CD) on plasma cholesterol and triacylglyceride concentrations and on antithrombotic activity were investigated in rats fed a control chow diet, or one either high in cholesterol or in saturated fat. The bleeding time of (cid:496) CD-fed groups was significantly prolonged by 293%, 157% and 218% in normal, high cholesterol and high fat diet fed groups, respectively, as compared to the control group(p<0.05). The whole blood clotting time was significantly increased by 202%, 168% and 211% in normal, high cholesterol and high fat diet fed groups as compared to control group, respectively(p<0.05). The (cid:496) CD diet caused a marked decrease in plasma total lipid (TL), triacylglyceride (TAG), total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) concentrations. The plasma TL concentration was significantly decreased by 70%, 82% and 87% in normal, high cholesterol and high fat diet fed groups as compared to the control group, respectively(p<0.05). The plasma TAG concentration was significantly decreased by 89%, 43% and 59% in normal, high cholesterol and high fat diet fed groups, respectively, as compared to the control group(p<0.05). The plasma TC concentration was significantly decreased by 28%, 62% and 36% in normal, high cholesterol and high fat diet fed groups, respectively, as compared to the control group(p<0.05). The LDL-C concentration was significantly decreased by 39%, 54% and 25% in normal, high cholesterol and high fat diet fed groups as compared to control group, respectively(p<0.05). The plasma total bile acids contents of (cid:496) CD group was significantly increased by 66%, 95% and 97% in normal, high cholesterol and high fat diet fed groups as compared to control group, respectively(p<0.05). The hepatic HMG-CoA reductase activity was significantly lowered by 41% in the (cid:496) CD-fed group compared to normal diet fed rats(p<0.05). The fecal steroid excretions of the (cid:496) CD groups was significantly increased by 167% in normal diet fed rats(p<0.05). These results suggest that the (cid:496) CD has a biological active function on antithrombotic activity and is hypolipidemic, hypotriglyceridemic and hypocholesterolimic agents. These are all effects that can help to prevent obesity and coronary heart disease in humans.
Journal of Entrepreneurship & Organization Management Investigating the Key Factors Affecting Restaurant Startup Intention

This study purports to investigate antecedents of startup intention, with particular reference to the restaurant business. The model of goal-directed behavior (MGB) provided theoretical background in developing the proposed research model with five constructs: attitude, subjective norm, perceived behavioral control, desire, and startup intention. Using convenience sampling, 379 usable data was collected from current employees of foodservice companies in South Korea. To test hypotheses, Structural Equation Modeling (SEM) technique was used. Analysis of the data found support for all of the hypothesized relationships. Specifically, all three independent variables were found to be positively related to desire, which was in turn significantly related to startup intention. The theoretical and practical implications of these findings are discussed in detail.
NRC Publications Archive Archives des publications du CNRC

This paper addresses the task of finding acronym-definition pairs in text. Most of the previous work on the topic is about systems that involve manually generated rules or regular expressions. In this paper, we present a supervised learning approach to the acronym identification task. Our approach reduces the search space of the supervised learning system by putting some weak constraints on the kinds of acronym-definition pairs that can be identified. We obtain results comparable to hand-crafted systems that use stronger constraints. We describe our method for reducing the search space, the features used by our supervised learning system, and our experiments with various learning schemes
Role of Continuous Glucose Monitoring (CGM) in Clinical Trials: Recommendations on Reporting Short running title: CGM in Trials: reporting recommendations

Oliver Schnell,1 Katharine Barnard,2 Richard Bergenstal,3 Emanuele Bosi,4 Satish Garg,5 Bruno Guerci,6 Thomas Haak,7 Irl B. Hirsch,8 Linong Ji,9 Shashank R. Joshi,10 Maarten Kamp,11 Lori Laffel,12 Chantal Mathieu,13 William H. Polonsky,14 Frank Snoek,15 and Philip Home,16 Forschergruppe Diabetes e.V. , Munich, Germany Bournemouth University, Bournemouth, U.K. International Diabetes Center at Park Nicollet, Minneapolis, MN Vita-Salute San Raffaele University, Milan, Italy Barbara Davis Center for Diabetes, University of Colorado at Denver, Denver, CO Centre Hospitalier Universitaire Nancy, Vandoeuvre-Les-Nancy, France Diabetes Center Mergentheim, Bad Mergentheim, Germany University of Washington School of Medicine, Seattle, WA Department of Endocrinology and Metabolism, Peking University People’s Hospital, Peking, China Indian Academy of Diabetes, Ahmedabad, India Queensland University of Technology, Brisbane, Australia Joslin Diabetes Center, Boston, MA University Hospital Gasthuisberg Leuven, Leuven, Belgium Behavioral Diabetes Institute, University of California, San Diego, San Diego, CA Department of Medical Psychology, VU University Medical Center and Academic Medical Center, Amsterdam, the Netherlands Institute of Cellular Medicine–Diabetes, Newcastle University, Newcastle upon Tyne, U.K.
Autophagy and polyglutamine diseases Selective degradation of protein aggregates by autophagy. Progress in Neurobiology

In polyglutamine diseases, an abnormally elongated polyglutamine tract results in protein misfolding and accumulation of intracellular aggregates. The length of the polyglutamine expansion correlates with the tendency of the mutant protein to aggregate, as well as with neuronal toxicity and earlier disease onset. Although currently there is no effective cure to prevent or slow down the progression of these neurodegenerative disorders, increasing the clearance of mutant proteins has been proposed as a potential therapeutic approach. The ubiquitin–proteasome system and autophagy are the two main degradative pathways responsible for eliminating misfolded and unnecessary proteins in the cell. We will review some of the studies that have proposed autophagy as a strategy to reduce the accumulation of polyglutamine-expanded protein aggregates and protect against mutant protein neurotoxicity. We will also discuss some of the currently known mechanisms that induce autophagy, which may be beneﬁcial for the treatment of these and other neurodegenerative disorders. by phosphorylation mediated by JNK1 under starvation conditions. Two ubiquitin-like reactions contribute to the elongation of phagophores. In the ﬁrst, Atg12 is conjugated to Atg5 via the concerted actions of Atg7 and Atg10 (E1-like and E2-like, respectively), and the resulting conjugate associates with Atg16L. This complex is found on the outer leaf of phagophores, and dissociates from completed autophagosomes. In the second ubiquitin-like reaction, LC3 is ﬁrst trimmed by Atg4B to form LC3-I, and is subsequently conjugated to phosphatidylethanolamine by Atg7 and Atg3 to form LC3-II. LC3-II is found on the inner and outer membranes of phagophores and autophagosomes, and is recycled from the outer membrane of mature autolysosomes by Atg4B.
This information is current as Glycoprotein 96 and Its Terminal Fragments Adjuvant Effect of Heat Shock Protein Virus-Specific Peptide and Evaluation of the Generation of Murine CTL by a Hepatitis B

Dong, George F. Gao and Po TienHongtao Li, Minghai Zhou, Jinle Han, Xiaodong Zhu, Taohttp://www.jimmunol.org/content/174/1/195J Immunol€2005; 174:195-204; ;Referenceshttp://www.jimmunol.org/content/174/1/195.full#ref-list-1This article cites 49 articles, 27 of which you can access for free at: Subscriptionshttp://jimmunol.org/subscriptionsInformation about subscribing to The Journal of Immunology is online at: Permissionshttp://www.aai. org/ji/copyright.htmlSubmit copyright permission requests at: Email Alertshttp://jimmunol.org/cgi/alerts/etocReceive free email-alerts when new articles cite this article. Sign up at:
Voxel-based morphometry & Diffusion Tensor Imaging analyses in the clinical cohort

Behavioural variant frontotemporal dementia (bvFTD) can present with episodic memory deficits as severe as those in Alzheimer’s disease (AD). Little is known of the integrity of grey matter areas and white matter tracts of the Papez memory circuit in these diseases. The integrity of the Papez circuit (hippocampus, fornix, mammillary bodies, anterior thalamus, cingulate cortex) was investigated in vivo and at postmortem in bvFTD and AD cohorts using voxel-based morphometry, diffusion tensor imaging and manual volumetric tracing. Our findings indicate that bvFTD and AD show similar degrees of hippocampal atrophy in vivo , but bvFTD patients show greater hippocampal atrophy at postmortem, with the FTLD-TDP subtype being particularly affected. Cingulate cortex findings show an expected atrophy pattern with bvFTD being affected more anteriorly and AD showing more posterior atrophy. More importantly, subcortical Papez circuit regions (fornix and anterior thalamus) were affected in bvFTD only, with atrophy in these regions determining the degree of amnesia in bvFTD. Hippocampal atrophy does not appear to be an efficient diagnostic marker for underlying bvFTD or AD pathology, although for bvFTD, episodic memory deficits in conjunction with marked hippocampal atrophy emerge as potential biomarkers for FTLD-TDP pathology. Subregions of Papez circuit were differentially affected in bvFTD and AD with subcortical regions determining the degree of episodic memory deficits in bvFTD. Subcortical atrophy should be taken into account when establishing whether the severe amnesia observed in a patient is likely due to bvFTD or AD pathology. whether (hippocampus, mammillary bodies, thalamus, cingulate and the main matter tract (fornix) differentially atrophied in bvFTD and We employed parallel in vivo and postmortem volumetric methods to establish the intactness of the circuit with disease progression. For the in vivo study, we conducted region of interest voxel-based morphometry and diffusion tensor imaging analyses in a clinical cohort of bvFTD and AD patients compared with controls. To confirm the clinical findings in a postmortem sample, we conducted volumetric analysis of grey matter regions of interest in pathologically-verified cases of bvFTD, AD and controls. Based on previous findings, we predicted that both groups would show similar atrophy of the hippocampus, with atrophy of the posterior cingulate cortex more substantial in AD and atrophy of the anterior cingulate cortex more substantial in bvFTD. We also predicted that the fornix, mammillary bodies and anterior would be in AD. posterior hippocampus and left anterior thalamus in comparison to the bvFTD- group. The opposite contrasts revealed no significant
Poor Agreement between Preoperative Biopsies and Pathological Resection Findings in IBD-Associated Dysplasia

Background: The decision to perform a proctocolectomy in patients with inflammatory bowel disease (IBD)-associateddysplasia is based on the degree of dysplasia on endoscopic biopsies. Unexpected pathological findings at the time of surgery can be troubling to patients. Therefore, we aimed to determine the extent of pathological agreement between endoscopic biopsies and surgical resection specimens in patients undergoing surgery at a tertiary referral center and to identify risk factors for poor agreement. Methods: Aretrospective review of patients who underwent surgery for IBD- associated dysplasia was performed. Data including demographics, disease history, endoscopic surveillance, and procedure type were collected. Risk factors for poor agreement were assessed using regression analysis. Results: 81 patients were identified; 60 (74%) male with a mean age of 54 years. Ulcerative colitis was seen in 70 (86%) while 11 (14%) had Crohn’s disease. In the colectomy specimens, newly diagnosed adenocarcinoma was identified in 16 (20%) and no dysplasia was seen in 16 (20%). Agreement between preoperative endoscopic biopsies and whole specimen pathology occurred in 33 (41%) patients ( r =0.17, p =0.14). Highest agreement was flat low grade dysplasia, while lowest agreement was indefinite dysplasia and polypoid low grade dysplasia. The diagnosis of cancer was more common with a preoperative diagnosis of high grade dysplasia. A repeat endoscopic evaluation at our institution was associated with lower likelihood of the findings of no dysplasia on the final surgical specimen. Conclusions: Agreement between preoperative biopsies and final pathology remains low, however, newer endoscopic techniques may provide better pathological correlation. This study highlights the necessity of preoperative counseling and joint decision making prior to surgery for dysplasia in IBD.
Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin 1 to Promote Embryo-tubal

Tubalectopicpregnanciesarealeadingcauseofglobalmaternalmorbidityandmortality.Previousinfectionwith Chlamydia trachomatis is a major risk factor for tubal embryo implantation but the biological mechanism behind this association is unclear. Successful intra-uterine embryo implantation is associated with increased expression of endometrial “ receptivity ” integrins (cell adhesion molecules). We examined integrin expression in Fallopian tubes of women with previous C. trachomatis infection, in mice experimentally infected with C. trachomatis , in immortalisedhumanoviductalepithelialcells(OE-E6/E7)andinan invitro modelofhumanembryoattachment (trophoblast spheroid-OE-E6/7 cell co-culture). Previous exposure with C. trachomatis increased Fallopian tube/ oviduct integrin-subunit beta-1 (ITGB1) in women and mice compared to controls. C. trachomatis increased OE-E6/E7 cellITGB1expression andpromotedtrophoblast attachmentto OE-E6/E7cellswhich wasnegatedbyanti- ITGB1-antibody.Wedemonstrate that infection with C.trachomatis increasestubal ITGB1 expression, predisposing to tubal embryo attachment and ectopic pregnancy. © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).