Miracle-dz/UniFAR-FTUs huggingface dataset:
Corrections

BIOCHEMISTRY, MEDICAL SCIENCES. For the article ‘‘Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187,’’ by Scott Classen, Stephane Olland, and James M. Berger, which appeared in issue 19, September 16, 2003, of Proc. Natl. Acad. Sci. USA (100, 10629–10634; first published September 8, 2003; 10.1073 pnas.1832879100), the authors note that the recently published structure of the Saccharomyces cerevisiae topoisomerase II ATPase region bound to adenosine 5 -[ , -imino]triphosphate (ADPNP) and ICRF-187 contains an error. The drugs ICRF-187 and ICRF-186 are the respective (S)and (R)-specific enantiomers of the racemic compound ICRF-159 (1, 2). During model building of our drug-inhibited complex, we relied on coordinates downloaded from the National Cancer Institute database for ICRF-187. We now have discovered that this file actually contains the ICRF-186 stereoisomer, and that the structure of the drug bound to topoisomerase II was correspondingly modeled incorrectly. Because the electron density for the ethanediyl linker region of the drug that contains the chiral center is poorly defined, the mistake was not immediately evident. We have now rebuilt and refined the correct (S)-enantiomeric ICRF-187 compound into the ATPase region (see corrected Fig. 5 and legend below). Compared with the original model containing (R)-ICRF-186, the new model with (S)-ICRF-187 alters the angle at which the single methyl group extends from the chiral center of the linker. Despite this change, the well defined electron density of the two dioxopiperazine rings constrains the ethanediyl linker of ICRF-187 to adopt a slightly different twist than observed previously, shifting the coordinate position of the methyl substituent by only 0.5 Å. As a consequence, the methyl–pi interaction postulated to exist between the ICRF-187 ethanediyl linker and Tyr28 is maintained. Other interactions observed between the drug and topoisomerase II are similarly unaffected, and all discussions and conclusions of the paper still stand. Indeed, both ICRF-186 and ICRF-187 inhibit topoisomerase II with virtually the same Ki values (2–4), an observation that can be explained by the absence of stereospecific interactions between these drugs and the enzyme. The new coordinates have been deposited in the Protein Data Bank, www.rcsb. org (PDB ID code 1QZR).
Changes of Cortisol and Glucose Concentrations in Rats Exposed to MR Imaging Field

Background: MR imaging is one of the best diagnostic modalities in medicine. During an MR imaging examination, three types of field are employed to produce images. Various experimental studies have been performed about the effects of each single type of field but only few studies are available on their combination to generate MR imaging. The main objective of this research work is to study the effects of MR imaging on the level of glucose and cortisol hormone. Methods: 40 adult male Wistar rats (220 ± 10 g) were randomly divided into 2 groups of exposed (20) and control (20) groups. They were exposed under diagnostic MR imaging of 1.5 T field strengths for 25 minutes. Then, immediately blood samples were isolated and level of serum glucose measured by Auto-analyzer and cortisol content of blood sera was assayed by radioimmunoassay (RIA). Results: Findings showed significant decreases in the levels of glucose and cortisol hormone after 25 minutes of exposure. Conclusion: MR imaging may have adverse effects on the level of glucose and cortisol hormone.
Chili Intake Is Inversely Associated with Chronic Kidney Disease among Adults: A Population-Based Study

We aimed to assess the association between chili consumption and kidney function and chronic kidney disease (CKD). Data from 8429 adults attending the China Health and Nutrition Survey were used. Chili intake was assessed using a 3 day, 24 h food record in combination with household food inventory between 1991 and 2009. CKD was defined as an estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m2, as measured in 2009. Logistic regression was used to assess the association. Of the 8429 participants, 1008 (12.0%) fit the definition of CKD. The prevalence of CKD was 13.1% in non-consumers of chili and 7.4% among those with chili intake above 50 g/day. After adjusting for demographics, lifestyle factors (i.e., smoking, alcohol drinking, physical activity), dietary patterns, and chronic conditions, the odds ratio (OR) (95% CI) for CKD across chili consumption levels of none, 1–20 g/day, 20.1–50 g/day, ≥50.1 g/day were 1.00 (reference), 0.82 (0.67–1.01), 0.83 (0.65–1.05), and 0.51 (0.35–0.75), respectively (p for trend 0.001). There was no interaction between chili intake with gender, income, urbanization, hypertension, obesity, or diabetes. This longitudinal large population-based study suggests that chili consumption is inversely associated with CKD, independent of lifestyle, hypertension, obesity, and overall dietary patterns.
Neuroaesthetics

The field of neuroaesthetics has gained in popularity in recent years but also attracted criticism from the perspectives both of the humanities and the sciences. In an effort to consolidate research in the field, we characterize neuroaesthetics as the cognitive neuroscience of aesthetic experience, drawing on long traditions of research in empirical aesthetics on the one hand and cognitive neuroscience on the other. We clarify the aims and scope of the field, identifying relations among neuroscientific investigations of aesthetics, beauty, and art. The approach we advocate takes as its object of study a wide spectrum of aesthetic experiences, resulting from interactions of individuals, sensory stimuli, and context. Drawing on its parent fields, a cognitive neuroscience of aesthetics would investigate the complex cognitive processes and functional networks of brain regions involved in those experiences without placing a value on them. Thus, the cognitive neuroscientific approach may develop in a way that is mutually complementary to approaches in the humanities.
Analysis of Wheat Bread-Making Gene (wbm) Evolution and Occurrence in Triticale Collection Reveal Origin via Interspecific Introgression into Chromosome 7AL

Bread-making quality is a crucial trait for wheat and triticale breeding. Several genes significantly influence these characteristics, including glutenin genes and the wheat bread-making (wbm) gene. World wheat collection screening showed that only a few percent of cultivars carry the valuable wbm variant, providing a useful source for wheat breeding. In contrast, no such analysis has been performed for triticale (wheat (AABB genome) × rye (RR) amphidiploid) collections. Despite the importance of the wbm gene, information about its origin and genomic organization is lacking. Here, using modern genomic resources available for wheat and its relatives, as well as PCR screening, we aimed to examine the evolution of the wbm gene and its appearance in the triticale genotype collection. Bioinformatics analysis revealed that the wheat Chinese Spring genome does not have the wbm gene but instead possesses the orthologous gene, called wbm-like located on chromosome 7A. The analysis of upstream and downstream regions revealed the insertion of LINE1 (Long Interspersed Nuclear Elements) retrotransposons and Mutator DNA transposon in close vicinity to wbm-like. Comparative analysis of the wbm-like region in wheat genotypes and closely related species showed low similarity between the wbm locus and other sequences, suggesting that wbm originated via introgression from unknown species. PCR markers were developed to distinguish wbm and wbm-like sequences, and triticale collection was screened resulting in the detection of three genotypes carrying wbm-specific introgression, providing a useful source for triticale breeding programs.
Cautious Adaptation of Defiant Components

Systems-of-systems are formed by the composition of independently created software components. These components are designed to satisfy their individual requirements, rather than the global requirements of the systems-of-systems. We refer to components that cannot be adapted to meet both individual and global requirements as "defiant" components. In this paper, we propose a "cautious" adaptation approach which supports changing the behaviour of such defiant components under exceptional conditions to satisfy global requirements, while continuing to guarantee the satisfaction of the components' individual requirements. The approach represents both normal and exceptional conditions as scenarios; models the behaviour of exceptional conditions as wrappers implemented using an aspect-oriented technique; and deals with both single and multiple instances of defiant components with different precedence order at runtime. We evaluated an implementation of the approach using drones and boats for an organ delivery application conceived by our industrial partners, in which we assess how the proposed approach help achieve the system-of-systems' global requirements while accommodating increased complexity of hybrid aspects such as multiplicity, precedence ordering, openness, and heterogeneity.
Ergonomics in Dentistry: The Absolute Dent-Ergonomics Workout.

Harsh Rajvanshi1, Hima Batra2, Saumya Singh3, Hafsa Effendi2, Ilham Zaidi4 1Post-graduate Student, Department of Public Health, Manipal University, Manipal, Karnataka, India, 2BDS, Department of Oral Medicine and Radiology, I.T. S Centre for Dental Studies and Research, Muradnagar, Uttar Pradesh, India, 3Post-graduate Student, Department of Public Health Dentistry, PostGraduate Institute of Dental Sciences, Pt. B D Sharma University of Health Sciences, Rohtak, Haryana, India, 4Student, Department of Oral Medicine and Radiology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India
Paying the Price: Sex Workers in Prison and the Reality of Stigma

Sex workers are a hidden demographic of the female prison estate. The Corston Report2 called for a new Reducing Reoffending Pathway 9 for women who have engaged in prostitution. Yet this involves having to locate the women who sell sex and having the support in place inside prison. Those engaging in sex work have specific needs relating to health care, securing housing, engaging with charities who assist with safer worker practices and exiting support, and coping with the additional stigma of being a prisoner who also works in the sex industry, particularly in a street-based setting. This paper derives from my Ph.D research at HMP New Hall. There are no official records kept for the number of sex workers in custody. And despite the plethora of research on various elements of the sex industry,3 there is little on the specific group of sex workers in prison.4 My study seeks to be a small part of remedying that shortfall.
Familial dementia with Pick's cells – a case report of probable familial Pick's disease

Abstract The clinical and pathological features are described in a case of prolonged dementia in a 59 year old man with familial dementia and extrapyramidal disorder. Postmortem examination showed severe fronto-temporal and basal ganglia atrophy, with many “ballooned neurons” in the residual cortex most likely representing Pick's disease. The differential diagnosis is discussed and aspects of this rare condition are reviewed.
What does a Single-item Measure of Self-rated Mental Health tell us? Systematic Review of Literature and Analysis of the Canadian Community Health Survey

A single-item measure of self-rated mental health (SRMH) asks respondents to rate their mental health on a 5-point scale from „excellent‟ to „poor‟. SRMH is being used increasingly in research and on population health surveys. However, little is known about this item, as there are no literature reviews and few formal validation studies. The aim of this study is to understand what SRMH measures by conducting the first known systematic review of SRMH literature, followed by analysis of the Canadian Community Health Survey (CCHS 1.2). Results of the systematic review reveal SRMH has relationships with mental health scales, mental disorders, self-rated health, health problems, service utilization, and service satisfaction. Analysis of CCHS 1.2 data finds SRMH is associated with psychiatric diagnoses, distress, physical health, and sociodemographic characteristics. Both studies conclude SRMH is measuring mental health and more; however, there needs to be more research to understand the specifics of these
Lathyrism

10n is effected by crawling on the balls of the eet and on the hands. Lathyrism was first recognised in Europe over yo. hundred and fifty years ago, and it is pvious that even in those early and unscientific ^lrnes it was ascribed to the ingestion of the ^eeds of various species of the genus Lathyrus, Gcause as early as 1671 the Duke of Wurtum^GlS issued an edict forbidding the use of these ^eds. Later, it was observed in Italy, France, pria and certain eastern countries. It is now y. seen in Europe and the chief interest in
ADDENDUM

Using multilevel Poisson modelling, we previously estimated the proportion of variance in the incidence of non-affective psychoses in Southeast London due to neighbourhood-level effects to be 23% (95% CI 9.9–42.2) (Kirkbride et al. 2007). This estimate was calculated by taking the raw parameter estimate from the multilevel Poisson model and applying the formula for the standard calculation of the interclass correlation coefficient (ICC) used for probit models. This formula had been previously used in a similar way for Poisson models (van Os et al. 2000), but a recent advance in statistical modelling suggests that this method of calculating the ICC leads to an overestimate of the proportion of variance attributable to neighbourhood-level factors in the Poisson case (Zammit et al. 2010). Modelling of ICC in hierarchical Poisson models is not straightforward and unlike the probit or logistic case, it is not possible to compute a single summary ICC. Rather, the ICC will vary according to the underlying stratification of data by population subgroup. To provide interpretable estimates from our findings, and consistent with the methods described in another recent publication (Zammit et al. 2010), we therefore refitted our previously reported models using logistic regression, which produces comparable measures of relative risk to the Poisson distribution provided the disease, like schizophrenia, is rare (Greenland & Thomas, 1982). From these, we were able to re-estimate the ICC at the neighbourhood level in Southeast London, using the latent variable approach recommended by Browne et al. (2005) :
An Overview of Oral Health Plan of India: Evaluating Current Status of Oral Healthcare and Advocacy for National Oral Health Policy

Oral diseases have a significant impact on health and add the socioeconomic burden. Oral diseases are preventable and potentially improve quality of life by reducing pain and economic burden. Thus, a wisely planned prevention and promotion strategies on a national level is important for society. A clear statement of oral health policy of a country is essential step for improvement of oral health by guiding oral health activities. Oral health policy in India was formulated in 1994. At present, there is a compelling need to evaluate current oral health status and re-structure policy guidelines ensuring proper planning and management of oral health care throughout the country. This review is an effort to evaluate current status and present strengths, weaknesses, opportunities, and threats analysis to identify scope for development of oral health policy in India.
Assessing Storm Tide Hazard for the North-West Coast of Australia using an Integrated High-Resolution Model System

Australia’s north-west coast extends across an active tropical cyclone region with a dynamic coastal zone which includes several regional towns as well as major infrastructure associated with Australia’s resources industry. The threat posed by tropical cyclone induced storm surge and associated storm tide is a significant concern for local communities and infrastructure owners in the region. A series of studies to define the storm tide hazard along Australia’s north-west coastline has delivered an integrated 10,000-year event dataset that defines wind and storm tide at high-resolution across the whole region. Storm surge and tide has been modelled with a hydrodynamic model extending across 2,000km of coast, developed using Delft-Flow Flexible Mesh (D-Flow FM). The model delivers high shoreline resolution with efficient model run times and can be deployed to a cloud computing environment. Validation of the hydrodynamic model to predicted and measured astronomical tide at standard port locations across the north-west region of Australia shows excellent agreement to tidal constants in both amplitude and phase. For storm surge simulations, cyclonic wind and pressure fields associated with historical cyclones were modelled with Baird’s in-house Cycwind program which combines a Holland et al. (2010) vortex model blended into Climate Forecast System Reanalysis (CFSR) regional scale atmospheric fields. The storm surge model was validated for 18 historical events with modelled peak storm surge showing very good agreement to measured data. The calibrated wind, tide and storm surge models have been combined with Baird’s Monte-Carlo cyclone track model for over 28,000 synthetic cyclone tracks impacting the north-west of Australia. The resulting highresolution storm tide outputs (≈ 1 km resolution) have been applied to an inundation mapping algorithm to determine storm surge and tide inundation hazard across the region at high-resolution (≈ 20 m) for use in applications such as coastal planning and infrastructure risk assessment.
Development of an atmospheric dispersion model for heavier-than-air gas mixtures. Volume 3. DEGADIS user's manual. Final report, September 1980-May 1985

The mathematical-modeling techniques used to predict atmospheric dispersion of heavier-than-air gases discussed in Volume 1 are briefly summarized; these techniques are incorporated in an interactive computer model DEGADIS. Details of DEGADIS implementation are briefly discussed. The necessary input information to simulate a heavier-than-air gas release with DEGADIS is summarized. Example simulations of a steady-state and transient release are included. A list of DEGADIS self-diagnostics with suggested actions are included. A listing of DEGADIS is included along with a partial list of program variables. Guidelines for installation of DEGADIS are presented.
A phase I study of escalating doses of lenalidomide combined with R-CHOP (R2-CHOP) for front-line treatment of B-cell lymphomas.

TPS297 Background: R-CHOP has become the standard front-line treatment of most patients (pts) with B-cell lymphoma. Single drug studies of lenalidomide in relapsed/refractory lymphoma have demonstrated a significant activity in both indolent and aggressive lymphomas. Methods: This phase I study was designed to determine the recommended dose of lenalinomide when given in combination with R-CHOP-21 for patients with previously untreated B-cell lymphoma. Pts with previously untreated CD20+ B-cell lymphoma received R-CHOP (rituximab 375 mg/m2, cyclophosphamide 750 mg/m2, doxorubicin 50 mg/m2, vincristine 1.4 mg/m2, all on day 1, prednisone 100 mg/m2 days 1-5) given every 3 weeks for 6 cycles. Oral lenalidomide was administered on days 1-14 of each cycle, and was dose escalated at 5 mg per dose level according to a standard 3+3 design. Pegfilgrastim was administered on day 4 and oral aspirin (100 mg) was given daily during the treatment. Maximum tolerated dose (MTD) was determined by the number of dose limitin.
VISIONTRAIN Ketut Fundana Variational Object Segmentation in Image Sequences

In this paper we propose a new method for variational segmentation of image sequences containing nonrigid, moving objects. The method is based on the Chan-Vese model augmented with a novel frame-to-frame interaction term, which allow us to update the segmentation result from one image frame to the next using the previous segmentation result as a shape prior. The interaction term is constructed to be poseinvariant and to allow moderate deformations in shape. It can handle the appearance of occlusions which otherwise can make segmentation fail. The performance of the model is illustrated with experiments on synthetic and real image sequences.
Circumcision

operation. Orlatorny is derived from the Hebrew orla: signifying prepuce. Dr Handvojel uses a special instrument, a pair of fenestrated forceps, armed with teeth to fix the mucous membrane, while a triangular blade glides along the slit in the forceps. It is applied perpendicularly to the direction of the penis, and amputates the prepuce by a mechanism analogous to that of the amygdalotome. The second treatise, entitled De la Circoncision / description d\in nouveau procede optfratoire, by Aissa Hamdy. The author is an Egyptian, and has observed in his own country many accidents resulting from the ignorance and inexperience of the barbers who perform the operation. He has seen a case of death from haemorrhage, cases of wounding the glans, etc. M. A'issa Hamdy uses a pair of compressing forceps, which pre-
Color-coded duplex sonography vs. 3.0 Tesla magnetic resonance angiography for detection of intracranial stenosis of the internal carotid artery: A prospective cohort study

Hemodynamic changes may provide important information for clinical decision-making in internal carotid artery (ICA) stenosis. The degree of stenosis is responsible for the hemodynamic changes. For detection of intracranial stenosis, each diagnostic method has its own advantages and disadvantages. The goal of the present study was to compare the sensitivity and accuracy of color-coded duplex sonography with that of magnetic resonance angiography (MRA) for the detection of intracranial stenosis. Patients with 3 vessels and/or left stem coronary artery disease were subjected to transcranial and extracranial color-coded duplex sonography (n=998), MRA (n=998) and invasive catheter angiography (n=939). The degree of stenosis was defined according to the Warfarin-Aspirin Symptomatic Intracranial Disease methodology. A ≥50% reduction in artery diameter was considered as a positive obstructive lesion. The benefits of each imaging method were assessed by clinical decision-making analysis. Color-coded duplex sonography and MRA, had sensitivities of 0.935 and 0.957 and accuracies of 0.92 and 0.974, respectively, when using invasive catheter angiography as a gold standard. The number of false-positive obstructive lesions detected by MRA was significantly higher than that for color-coded duplex sonography (53 vs. 13, P<0.0001). Color-coded duplex sonography was able to detect an obstructive lesion in one single image for ICAs with ≥57% stenosis, while MRA was only capable of detecting an obstructive lesion in one single image for ICAs with ≥80% stenosis. In conclusion, color-coded duplex sonography is a reliable method for the detection of intracranial stenosis in patients with coronary artery disease.