Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlations of trait and state emotions with utilitarian moral judgements

ABSTRACT In four experiments, we asked subjects for judgements about scenarios that pit utilitarian outcomes against deontological moral rules, for example, saving more lives vs. a rule against active killing. We measured trait emotions of anger, disgust, sympathy and empathy (the last two in both specific and general forms, the latter referring to large groups of people), asked about the same emotions after each scenario (state emotions). We found that utilitarian responding to the scenarios, and higher scores on a utilitarianism scale, were correlated negatively with disgust, positively (but weakly and inconsistently) with anger, positively with specific sympathy and state sympathy, and less so with general sympathy or empathy. In a fifth experiment, we asked about anger and sympathy for specific outcomes, and we found that these are consistently predictive of utilitarian responding.
Electro-Optical Properties of Carbon Nanotubes Obtained by High Density Plasma Chemical Vapor Deposition

In this work, we studied the electro-optical properties of high-aligned carbon nanotubes deposited at room temperature. For this, we used the High Density Plasma Chemical Vapor Deposition system. This system uses a new concept of plasma generation: a planar coil is coupled to an RF system for plasma generation. This was used together with an electrostatic shield, for plasma densification, thereby obtaining high-density plasmas. The carbon nanotubes were deposited using pure methane plasmas. Three methods were used for the surface modification of the sample: reference substrate (silicon wafer only submitted to a chemical cleaning), silicon wafer with surface roughness generated by plasma etching, silicon wafer with a thin iron film and silicon wafer with diamond nano powder used as precursor materials. For each kind of silicon wafer surface, the carbon nanotubes were deposited with two different deposition times (two and three hours). The carbon nanotubes structural characteristics were analyzed by Atomic Force Microscope and Scanning Electronic Microscope. The carbon nanotubes electrical characteristics were observed by Raman Spectroscopy and the carbon nanotubes electro-optical properties were analyzed by current vs voltage electrical measurements and photo-luminescence spectroscopy measurements. The photoelectric effect in the carbon nanotubes were determined by photo-induced current measurements. In this work, we obtained carbon nanotubes with semiconductor properties and carbon nanotubes with metallic properties. The electro-optical effects depend strongly on the substrate preparation and the deposition parameters of the carbon nanotubes. The carbon nanotubes are high aligned and show singular properties that can be used for many applications.
Pseudouridine-Free Escherichia coli Ribosomes

ABSTRACT Pseudouridine (Ψ) is present at conserved, functionally important regions in the ribosomal RNAs (rRNAs) from all three domains of life. Little, however, is known about the functions of Ψ modifications in bacterial ribosomes. An Escherichia coli strain has been constructed in which all seven rRNA Ψ synthases have been inactivated and whose ribosomes are devoid of all Ψs. Surprisingly, this strain displays only minor defects in ribosome biogenesis and function, and cell growth is only modestly affected. This is in contrast to a strong requirement for Ψ in eukaryotic ribosomes and suggests divergent roles for rRNA Ψ modifications in these two domains. IMPORTANCE Pseudouridine (Ψ) is the most abundant posttranscriptional modification in RNAs. In the ribosome, Ψ modifications are typically located at conserved, critical regions, suggesting they play an important functional role. In eukarya and archaea, rRNAs are modified by a single pseudouridine synthase (PUS) enzyme, targeted to rRNA via a snoRNA-dependent mechanism, while bacteria use multiple stand-alone PUS enzymes. Disruption of Ψ modification of rRNA in eukarya seriously impairs ribosome function and cell growth. We have constructed an E. coli multiple deletion strain lacking all Ψ modifications in rRNA. In contrast to the equivalent eukaryotic mutants, the E. coli strain is only modestly affected in growth, decoding, and ribosome biogenesis, indicating a differential requirement for Ψ modifications in these two domains.
Structure design and simulation on bionic lower extremity rehabilitation robot

Lower extremity exoskeleton rehabilitation robot is one of the focus in the field of robotics developed to help physical therapists complete rehabilitative therapy. However, the traditional rehabilitation robot cannot fit specific human body structure parameters well very, which may reduce the rehabilitation effect. To overcome this problem, this paper mainly discusses the Design and Simulation on a new bionic lower extremity rehabilitation robot. Firstly, a three-dimension model has been established in SolidWorks. Secondly the kinematic analysis has been made. Then, the model has been imported into ADAMS to verify the correctness of the analysis by simulation. At last, based the PID control system and the simulation model created in ADAMS, the union simulation by ADAMS and Matlab has been created to verify its control performance. The union simulation shows that this rehabilitation robot can follow the designed trajectory with good stability and smaller control difficulty.
Cerebral Blood Flow Autoregulation in Sepsis for the Intensivist: Why Its Monitoring May Be the Future of Individualized Care

Cerebral blood flow (CBF) autoregulation maintains consistent blood flow across a range of blood pressures (BPs). Sepsis is a common cause of systemic hypotension and cerebral dysfunction. Guidelines for BP management in sepsis are based on historical concepts of CBF autoregulation that have now evolved with the availability of more precise technology for its measurement. In this article, we provide a narrative review of methods of monitoring CBF autoregulation, the cerebral effects of sepsis, and the current knowledge of CBF autoregulation in sepsis. Current guidelines for BP management in sepsis are based on a goal of maintaining mean arterial pressure (MAP) above the lower limit of CBF autoregulation. Bedside tools are now available to monitor CBF autoregulation continuously. These data reveal that individual BP goals determined from CBF autoregulation monitoring are more variable than previously expected. In patients undergoing cardiac surgery with cardiopulmonary bypass, for example, the lower limit of autoregulation varied between a MAP of 40 to 90 mm Hg. Studies of CBF autoregulation in sepsis suggest patients frequently manifest impaired CBF autoregulation, possibly a result of BP below the lower limit of autoregulation, particularly in early sepsis or with sepsis-associated encephalopathy. This suggests that the present consensus guidelines for BP management in sepsis may expose some patients to both cerebral hypoperfusion and cerebral hyperperfusion, potentially resulting in damage to brain parenchyma. The future use of novel techniques to study and clinically monitor CBF autoregulation could provide insight into the cerebral pathophysiology of sepsis and offer more precise treatments that may improve functional and cognitive outcomes for survivors of sepsis.
The Complete mitochondrial genome of the Neochauliodes rotundatus (Megaloptera: Corydalidae)

Abstract The mitochondrial genome of Neochauliodes rotundatus (Megaloptera: Corydalidae) is a circular molecule of 15,774 bp in length, containing 37 typical mitochondrial genes: 13 protein-coding genes (PCGs), 2 ribosomal RNAs, 22 transfer RNAs and a non-coding AT-rich region. Its gene order and arrangement are identical to the common type found in most insect mitogenomes. All PCGs start with a typical ATN codon except for the ND1 which uses TTG as its start codon; all PCGs terminate in the common stop codon TAA or TAG, except for the COI, COIII, ND3, ND5, ND4 and CYTB which use single T as their stop codons. The 1061 bp non-coding AT-rich region is located between rrnS and tRNAlle genes, containing some structures of repeated motifs and microsatellite-like elements characteristic of the Megaloptera insects.
Cost-utility analysis of antiviral use under pandemic influenza using a novel approach – linking pharmacology, epidemiology and heath economics

Abstract Simulation models are used widely in pharmacology, epidemiology and health economics (HEs). However, there have been no attempts to incorporate models from these disciplines into a single integrated model. Accordingly, we explored this linkage to evaluate the epidemiological and economic impact of oseltamivir dose optimisation in supporting pandemic influenza planning in the USA. An HE decision analytic model was linked to a pharmacokinetic/pharmacodynamics (PK/PD) – dynamic transmission model simulating the impact of pandemic influenza with low virulence and low transmissibility and, high virulence and high transmissibility. The cost-utility analysis was from the payer and societal perspectives, comparing oseltamivir 75 and 150 mg twice daily (BID) to no treatment over a 1-year time horizon. Model parameters were derived from published studies. Outcomes were measured as cost per quality-adjusted life year (QALY) gained. Sensitivity analyses were performed to examine the integrated model's robustness. Under both pandemic scenarios, compared to no treatment, the use of oseltamivir 75 or 150 mg BID led to a significant reduction of influenza episodes and influenza-related deaths, translating to substantial savings of QALYs. Overall drug costs were offset by the reduction of both direct and indirect costs, making these two interventions cost-saving from both perspectives. The results were sensitive to the proportion of inpatient presentation at the emergency visit and patients’ quality of life. Integrating PK/PD–EPI/HE models is achievable. Whilst further refinement of this novel linkage model to more closely mimic the reality is needed, the current study has generated useful insights to support influenza pandemic planning.
Transformable multirotor with two-dimensional multilinks: Modeling, control, and whole-body aerial manipulation

A multirotor with two-dimensional multilinks is proposed to perform aerial transformation and aerial manipulation. First, a modular link structure that comprises a multirotor with a reliable internal communication system was initially developed. Second, a flight control method was further introduced on the basis of linear–quadratic–integral optimal control for aerial transformation. A relaxed hovering solution that neglects the yaw motion stability is proposed to enable stable flight under a certain singular form. Third, the transformable robot was employed as an entire gripper with regards to grasping to perform the whole-body aerial manipulation. A grasp-form searching method was developed to optimize hovering thrust force and joint torque under force-closure grasp, and was followed by an aerial approach and grasp-motion strategy to fulfill the resulting desired grasp form. Finally, experimental results demonstrate the stable aerial transformation as well as the feasibility of the whole-body aerial manipulation system to grasp and carry different types of objects.
Rest interval duration does not influence adaptations in acid/base transport proteins following 10 wk of sprint-interval training in active women.

The removal of protons (H+) produced during intense exercise is important for skeletal muscle function, yet it remains unclear how best to structure exercise training to improve muscle pH regulation. We investigated whether 4 wk of work-matched sprint-interval trining (SIT), performed 3 days/wk, with either 1 (Rest-1; n = 7) or 5 (Rest-5; n = 7) min of rest between sprints, influenced adaptations in acid/base transport protein content, nonbicarbonate muscle buffer capacity (βmin vitro), and exercise capacity in active women. Following 1 wk of posttesting, comprising a biopsy, a repeated-sprint ability (RSA) test, and a graded-exercise test, maintenance of adaptations was then studied by reducing SIT volume to 1 day/wk for a further 5 wk. After 4 wk of SIT, there was increased protein abundance of monocarboxylate transporter (MCT)-1, sodium/hydrogen exchanger (NHE)-1, and carbonic anhydrase (CA) XIV for both groups, but rest interval duration did not influence the adaptive response. In contrast, greater improvements in total work performed during the RSA test after 4 wk of SIT were evident for Rest-5 compared with Rest-1 (effect size: 0.51; 90% confidence limits ±0.37), whereas both groups had similarly modest improvements in V̇o2peak When training volume was reduced to 1 day/wk, enhanced acid/base transport protein abundance was maintained, although NHE1 content increased further for Rest-5 only. Finally, our data support intracellular lactate as a signaling molecule for inducing MCT1 expression, but neither lactate nor H+ accumulation appears to be important signaling factors in MCT4 regulation.
Association between Post-Cancer Diagnosis Dietary Inflammatory Potential and Mortality among Invasive Breast Cancer Survivors in the Women's Health Initiative

Background: Inflammation is important in chronic disease and can be modulated by dietary exposures. Our aim was to examine whether the inflammatory potential of diet after cancer diagnosis, assessed using the dietary inflammatory index (DII), is associated with all-cause and cause-specific mortality among women diagnosed with invasive breast cancer in the Women's Health Initiative (WHI). Methods: Our analytic cohort included 2,150 postmenopausal women, ages 50 to 79 years at baseline, who developed invasive breast cancer during follow-up and completed a food frequency questionnaire (FFQ) on average 1.5 years after diagnosis. Women were followed from breast cancer diagnosis until death or the end of follow-up by October 2014. Energy-adjusted DII (E-DII) scores were calculated from food plus supplements using a nutrient–density approach. Cox proportional hazards models were fit to estimate multivariable-adjusted HRs and 95% confidence intervals (CIs) for all-cause, breast cancer–specific, and cardiovascular disease (CVD) mortality. Results: After a median 13.3 years of follow-up, 580 deaths from any cause occurred, including 212 breast cancer deaths and 103 CVD deaths. Lower (i.e., more anti-inflammatory) E-DII scores were associated with a lower risk of CVD mortality (HRQ1VSQ4 = 0.44; 95% CI, 0.24–0.82; Ptrend = 0.005), but not with breast cancer–specific mortality (HRQ1VSQ4 = 0.96; 95% CI, 0.62–1.49; Ptrend = 0.96) or all-cause mortality (HRQ1VSQ4 = 0.82; 95% CI, 0.63–1.05; Ptrend = 0.17). Conclusions: Consuming a more anti-inflammatory diet after breast cancer diagnosis may be a means for reducing risk of death from CVD. Impact: Survival after invasive breast cancer diagnosis may be improved by consumption of an anti-inflammatory diet. Cancer Epidemiol Biomarkers Prev; 27(4); 454–63. ©2018 AACR.
Site dilution in SrRuO3: effects on structural and magnetic properties

We have investigated the effect of site dilution with substitution of nonmagnetic element in SrRu1−xTixO3 (x ⩽ 0.7). The nature of ferromagnetic state in SrRuO3 is believed to be of itinerant type with transition temperature Tc∼162 K. Crystallographically, SrRuO3 has a distorted orthorhombic structure. Substitution of Ti+4 (3d0) for Ru+4 (4d4), however, does not introduce significant structural modification due to their matching ionic radii. This substitution, on the other hand, is expected to tune the electronic correlation effect and the d electron density in the system. With Ti substitution, we find that magnetic moment and Curie temperature decreases but Tc remains unchanged which has been attributed to opposite tuning of electron correlation effect and density of states within the framework of itinerant ferromagnetism. The estimated critical exponent (β) related to magnetization implies a mean-field type of magnetic nature in SrRuO3. The value of β further increases with x which is understood from the dilution effect of magnetic lattice. The system evolves to exhibit Griffiths phase like behavior above Tc which is usually realized in diluted ferromagnet following local moment model of magnetism. Our detail analysis of magnetization data indicates that magnetic state in SrRuO3 has contribution from both itinerant and local moment model of magnetism.
Gold nanoparticles applications: from artificial enzyme till drug delivery

Abstract Today, nano-medicine promotes new therapeutics and diagnostics tools, including sensing of biomolecules as a biosensor, cancer chemotherapy and drug or gene delivery. Because of small size and biocompatibility of gold nanoparticles (GNPs), they become a good candidate for biological application. Also, thanks to their biological and chemical properties, they can mimic function of some enzymes including super oxide dismutase (SOD), esterase, etc. Also, biomaterials and bioengineering have grown so fast since the last decade for many therapeutic applications such as tissue regeneration. Among these cutting edge technology, nanomaterials find the way to becoming a very powerful tool for using in many fields of researchers including biosensing, gene therapy and chemotherapy. In this review, we focused on some biological applications of GNPs in biology and medicine.
Tissue Factor: An Essential Mediator of Hemostasis and Trigger of Thrombosis

Tissue factor (TF) is the high-affinity receptor and cofactor for factor (F)VII/VIIa. The TF-FVIIa complex is the primary initiator of blood coagulation and plays an essential role in hemostasis. TF is expressed on perivascular cells and epithelial cells at organ and body surfaces where it forms a hemostatic barrier. TF also provides additional hemostatic protection to vital organs, such as the brain, lung, and heart. Under pathological conditions, TF can trigger both arterial and venous thrombosis. For instance, atherosclerotic plaques contain high levels of TF on macrophage foam cells and microvesicles that drives thrombus formation after plaque rupture. In sepsis, inducible TF expression on monocytes leads to disseminated intravascular coagulation. In cancer patients, tumors release TF-positive microvesicles into the circulation that may contribute to venous thrombosis. TF also has nonhemostatic roles. For instance, TF-dependent activation of the coagulation cascade generates coagulation proteases, such as FVIIa, FXa, and thrombin, which induce signaling in a variety of cells by cleavage of protease-activated receptors. This review will focus on the roles of TF in protective hemostasis and pathological thrombosis.
Cortico‐cortical and motor evoked potentials to single and paired‐pulse stimuli: An exploratory transcranial magnetic and intracranial electric brain stimulation study

Paired‐pulse (PP) paradigms are commonly employed to assess in vivo cortical excitability using transcranial magnetic stimulation (TMS) to stimulate the primary motor cortex and modulate the induced motor evoked potential (MEP). Single‐pulse cortical direct electrical stimulation (DES) during intracerebral EEG monitoring allows the investigation of brain connectivity by eliciting cortico‐cortical evoked potentials (CCEPs). However, PP paradigm using intracerebral DES has rarely been reported and has never been previously compared with TMS.
Efficient Asymmetric Index Encapsulation Scheme for Anonymous Content Centric Networking

Content Centric Networking (CCN) is an effective communication paradigm that well matches the features of wireless environments. To be considered a viable candidate in the emerging wireless networks, despite the clear benefits of location-independent security, CCN must at least have parity with existing solutions for confidential and anonymous communication. This paper designs a new cryptographic scheme, called Asymmetric Index Encapsulation (AIE), that enables the router to test whether an encapsulated header matches the token without learning anything else about both of them. We suggest using the AIE as the core protocol of anonymous Content Centric Networking. A construction of AIE which strikes a balance between efficiency and security is given. The scheme is proved to be secure based on the DBDH assumption in the random oracle with tight reduction, while the encapsulated header and the token in our system consist of only three elements.
Differential Effects of Selective and Nonselective Potassium Channel Inhibitors in Ovine Endotoxemic Shock (Macrocirculation) and in a Rat Model of Septic Shock (Microcirculation)

Background: Potassium-(K+)-channel inhibitors may increase systemic vascular resistance in vasodilatory shock states. Objective: The purpose of the present study was to compare the macro- and microvascular effects of the adenosine triphosphate-sensitive K+-channel-(K+ATP)-inhibitor glipizide and the nonselective K+-channel inhibitor tetraethylammonium (TEA) in ovine endotoxemic shock and septic shock in rats. Design: Two randomized, controlled laboratory studies. Animals: Thirty female sheep and 40 male Sprague Dawley rats. Setting: Animal research facility Intervention: Systemic hemodynamics were analyzed in ovine endotoxemic shock with guideline-oriented supportive therapy. Sheep were allocated to three treatment groups for 12 h: glipizide 10 mg kg−1·h−1, TEA 8 mg kg−1·h−1, or 0.9% saline. The microvascular effects of each drug were evaluated in septic rats (cecal ligation and puncture model) receiving a 2-h infusion of each study drug: glipizide 20 mg kg−1·h−1; TEA 50 mg kg−1·h−1, or 0.9% saline, respectively, followed by intravital microscopy of villi microcirculation. Results: Compared with the control group, glipizide infusion increased systemic vascular resistance index and decreased cardiac index and heart rate (HR) in sheep (P < 0.05), whereas TEA infusion decreased HR and resulted in a decreased survival time (P = 0.001). In rats, glipizide infusion resulted in an increase in mean arterial pressure and a decrease in HR compared with baseline measurement (P < 0.05) without relevant effects on the villi microcirculation. TEA decreased HR and decreased capillary perfusion of the villi microcirculation compared with the sham group (P = 0.002). Conclusions: Selective inhibition of K+ATP-channels in ovine endotoxemic shock with glipizide partially restored vasomotor tone without exerting harmful effects on intestinal microcirculation in septic shock in rats. On the contrary, nonselective K+-channel inhibition with TEA showed deleterious effects in both models, including impaired microcirculation and decreased survival time. Future research on glipizide in vasodilatory shock may be warranted.
Cytoprotective and antioxidant effects of the red alga Alsidium corallinum against hydrogen peroxide-induced toxicity in rat cardiomyocytes

Abstract Context: Sepsis is the manifestation of the immune and inflammatory responses to infection that may ultimately result in multiorgan failure. Many substances are involved in myocardial dysfunction in sepsis, including hydrogen peroxide. Objective: This study evaluates the protective activity of the red alga Alsidium corallinum against hydrogen peroxide (H2O2)-induced toxicity in H9c2 cardiomyocytes. Material and methods: The biological properties of A. corallinum were firstly investigated. Secondly, the H9c2 cells were pre-treated with alga extract, and then exposed to H2O2. Results: Our results showed richness of the alga in antioxidant compounds, and its biological activities. H2O2 induced a morphological changes and decrease in H9c2 cell viability correlating with an increase in enzymatic and non-enzymatic antioxidants. Pre-treatment with A. corallinum, reduces toxicity and decreased the antioxidants status induced by H2O2. Conclusion: These findings indicated for the first time the protective effect of A. corallinum against H2O2-induced toxicity in H9c2 cells.