Miracle-dz/UniFAR-FTUs huggingface dataset:
Expert system for applying coagulant in water treatment: case study in Nobres (Brazil)

In most Brazilian municipalities, the water supply comes from surface water sources, requiring infrastructure and human resources, especially water treatment. Where infrastructure and human resources are lacking, auxiliary methods and/or substitutes are valuable. The aim of this work was to develop an expert system (ES) to determine and apply coagulant dosing, in real time, in a water treatment plant (WTP). The ES was developed and evaluated at the WTP in Nobres, Mato Grosso (MT) state, Brazil. It is called AIASD (artificial intelligence for aluminium sulphate dosage) and was validated using the Turing test. It can determine and apply coagulant dosing in water treatment. AIASD contributed successfully to WTP operations in Nobres and other WTPs; making decisions and applying the coagulant dosing necessary for water treatment.
The Dyadic Complexity of Stressor-Related Disorders in Patients with Schizophrenia and their Caregivers

Stress impact in patients with schizophrenia is decisive on their well-being; however, there is not much evidence of the more complex aspects about the interaction with the caregivers, about Posttraumatic Stress Disorder symptoms (PTSD), Complex Posttraumatic Stress Disorder (C-PTSD) and Complicated Grief (CG). Pairing patients with their caregivers and using the most recent methodologies for C-PTSD and CG assessment it is possible to clarify connections between those comorbid interactions in such a specific paired sample. The sample is composed of patients with schizophrenia (n=25) paired with their caregivers (n=21); patients without schizophrenia (n=24) paired with their caregivers (n=24) and a reference group (n=110). After informed consent procedures, we use a sociodemographic questionnaire, Positive and Negative Syndrome Scale (PANSS), Inventory of Complicated Grief (ICG), Trauma Questionnaire (ICD-11) and Life Events List (LEC). Patients with schizophrenia and their caregivers present more PTSD and less CG symptoms than the reference sample. There is a pattern of reverse correlation between patients PTSD symptoms and their caregivers symptoms (PTSD; C-PTSD and CG), being especially relevant for C-PTDS symptoms. Such negative correlation does not exist in the paired group of caregivers and patients without schizophrenia. This may be the result of the possible relation established (of protection/ dependence) between the caregiver and the patient and may be specifically associated with difficulties of emotional regulation. We present evidence about CG, PTSD and C-PTSD symptoms relevance in both caregivers and patients with schizophrenia, therefore, the need to recognize and address those potential problems.
PPA_A_292178 411..422

*These authors contributed equally to this work Background: In 2016, the Global Burden of Disease study pointed out that cardiovascular disease (CVDs) were the most common causes of death and accounted for the largest disease burden worldwide. Percutaneous coronary intervention (PCI) is one of the main treatments for coronary artery disease (CAD). Moreover, homeand exercise-based cardiac rehabilitation (CR) is of great importance for improving the prognosis of patients undergoing PCI. However, poor adherence to CR remains a challenging problem in these patients. Aim: This study aimed to investigate the current status of adherence to homeand exercisebased CR in patients undergoing PCI and to explore the factors affecting patient adherence to homeand exercise-based CR. Methods: This study was a prospective longitudinal survey that included 300 patients who met the established criteria. The selected patients completed a pre-hospital discharge questionnaire, which targeted factors that may affect patient adherence to homeand exercisebased CR. All patients were followed up 1 month after the discharge from hospitals. Results: This study analyzed 283 questionnaires and found that only 64.66% of patients had good adherence to homeand exercise-based CR. Eight independent variables, namely, shared decision-making (SDM), age, dimension of risk factors, predisposing factors, treatment methods, secondary prevention in the Perceived Knowledge Scale for CAD, and dimension of life and emotional management in the Scale of Self-Management with Coronary Artery Disease, were identified as the main factors affecting patient adherence to homeand exercise-based CR, which explains 88.9% variation (Nagel kerke R = 0.889). Conclusion: Patients who underwent PCI had poor adherence to homeand exercise-based CR. Age, SDM, knowledge about CAD, and self-management behavior were identified as independent factors affecting patient adherence to CR after PCI.
Cost Effective Vegetation Management on a Recently Cleared Electric Transmission Line Right-of-way

Several application modes and methods (schemes) of using herbicides are available to control undesirable vegetation on electric transmission line rights-of-way (ROW). Preferential use of a management scheme can be based on its cost effectiveness, i.e., degree of vegetation control and treatment cost. A treatment that increases/maintains desirable plants, decreases/maintains undesirable plants, and has relatively low cost, can be considered cost effective. Three common herbicides, 2,4-D, picloram and triclopyr, were applied in the field to test treatment mode (selective and nonselective) and method (cut stump, basal, and stem-foliar) effects on cost effectiveness during initial clearing and first and second conversion cycles on one electric transmission line ROW in Upstate New York. Clear or selective cutting with no herbicide was most cost effective during initial clearing. Nonselective and selective stem-foliar schemes were most cost effective during the first and second conversion cycles, respectively.
Discussion of “Statistical Modeling of Spatial Extremes”

The review paper on spatial extremes by Davison, Padoan and Ribatet is a most welcome contribution. The authors cover quite a lot of ground, making con-nections between different approaches while highlight-ing important differences. In particular, we applaud their careful attention to model checking, which can be difﬁcult in general but particularly so for spatial extreme value models.
Rothamsted Repository Download Phylogeny and gene expression of the complete NITRATE TRANSPORTER 1/PEPTIDE TRANSPORTER FAMILY (NPF) in Triticum

NPF genes encode membrane transporters involved in the transport of a large variety of substrates including nitrate and peptides. The NPF gene family has been described for many plants, but the whole NPF gene family for wheat has not been completely identified. The release of the wheat reference genome has enabled the identification of the entire wheat NPF gene family. A systematic analysis of the whole wheat NPF gene family was performed, including responses of specific gene expression to development and nitrogen supply. A total of 331 NPF genes (113 homoeologous groups) have been identified in wheat. The chromosomal location of the NPF genes is unevenly distributed with predominant occurrence in the long arms of the chromosomes. The phylogenetic analysis indicated that wheat NPF genes are closely clustered with Arabidopsis , Brachypodium and rice orthologs, and subdivided into eight subfamilies. The expression profiles of wheat NPF genes were examined using RNA-seq data and identified a subset of 44 NPF genes (homoeologous groups) with contrasting expression responses to nitrogen and/or development in different tissues. The systematic identification of gene composition, chromosomal locations, evolutionary relationships and expression profiles contributes to a better understanding of the roles of the wheat NPF genes and lays the foundation for further functional analysis in wheat. experiments for verification of the putative roles and functions of individual NPF genes in nitrogen utilization. The results offer a foundation for future work aimed at both elucidating the molecular mechanisms underlying NPF genes functions in nitrogen utilization and optimizing productivity and NUE by manipulation of these NPF genes in wheat.
Inﬂuence of Inﬂammation on Voriconazole Metabolism

Voriconazole pharmacokinetics shows a large inter- and intrapatient variability. Inﬂammation is associated with changes in the expression of CYP isoenzymes. Here, we evaluated the inﬂuence of inﬂammation, marked by C-reactive protein (CRP) levels in blood, on the metabolism of voriconazole. Observational data showed an association between CRP level and the ratio of voriconazole N -oxide to voriconazole.
A Versatile Collider for Ultracold Atoms

This thesis describes the construction of a dual species setup using fermionic K and bosonic Rb with the goal of cooling to ultracold temperatures and quantum degeneracy, and also perfoming precision collision experiments using a novel optical collider. The setup is composed of a dual species magnetooptical trap, with transfer to an ultrahigh vacuum science cell achieved using a mechanical transport scheme. Atoms are cooled to ultracold temperatures using forced radio frequency evaporation in a Ioffe-Pritchard style magnetic trap. The optical collider utilises the optical dipole force to trap a sample of ultracold atoms and accelerate them towards a target sample using an acoustooptic modulator. The process of cooling Rb atoms in the |F = 2,mF = 2〉 hyperfine state to Bose-Einstein condensation is described, as well as progress towards production of ultracold K. Design, implementation, and characterisation of the optical collider is provided, showing that it is a precision metrology device.
Molten Salt Synthesis of Nanolaminated Sc 2 SnC MAX Phase

: The MAX phases are a family of of ternary layered material with both metal and ceramic properties, and it is also precursor materials for synthesis of two-dimensional MXenes. The theory predicts that there are more than 600 kinds of stable ternary layered MAX phase materials. Now, more than 80 kinds of ternary layered MAX phases that the M-site elements are mainly from early transition metal have been experimental synthesized, but few researches are reported on MAX phases where M is a rare earth element. In this study, Sc, Sn and C powders were used as raw materials to synthesize a novel ternary Sc 2 SnC MAX phase via molten salt method. Phase composition and microstructure of Sc 2 SnC were confirmed by X-ray diffraction, scanning electron microscope and X-ray energy spectrum analysis. And, the structural stability, lattice parameters, mechanical and electronic properties of Sc 2 SnC were investigated via density functional theory. The theoretical results show that Sc 2 SnC is thermodynamically stable, and the Sc 2 SnC is metallic in nature where the contribution from Sc-3d states dominates the electronic conductivity at the Fermi level. This study provides a route to ex-plore more unknown ternary layered rare earth compounds Re n+1 SnC n (Re=Sc, Y, La-Nd, n=1) and corresponding rare earth MXenes.
Aerial Scene Classification by Surf Feature Extarction Using Unsupervised Learning

The high-resolution satellite imagery which consisted of rich data allow us to directly model aerial scenes by understanding their spatial and structural patterns. Efficient representation and recognition of scenes from image data are challenging. For satellite image analysis, pixel and object based classification approaches are widely used but these approaches often exploit the high-fidelity image data only in a limited way. In this paper, we explore a supervised feature learning approach for aerial scene classification. This system follows some peculiar steps like Noise Removal, Feature Extraction (SURF), Feature Learning and Classification. SURF features are extracted from the input image and classification is done by Latent Dirichlet Allocation Algorithm. This technique can be applied to several challenging aerial scene data sets: ORNL-I data set consisting of 1-m spatial resolution satellite imagery, UCMERCED data set with sub-meter resolution, and ORNL-II data set for large-facility scene detection. The proposed method is highly effective in developing a detection system that can be used to automatically scan large-scale high-resolution satellite imagery for detecting large facilities such as a shopping mall.
Type 2 diabetes and cancer: an umbrella review of observational and Mendelian randomisation studies

Background Type 2 diabetes(T2DM) has been associated with an increased risk of developing several common cancers, but it is unclear whether this association is causal. We aimed to summarise the evidence on T2DM and cancer and evaluate the validity of associations from both observational and Mendelian randomisation(MR) studies. Methods We performed an umbrella review of the evidence across meta-analyses of observational studies that examined associations of T2DM with risk of developing or dying from site-specific cancers, and MR studies that explored the potential causal association of T2DM and associated biomarkers with cancer risk. We identified eligible observational meta-analyses that assessed associations between T2DM and cancer incidence for 18 cancer sites, cancer mortality for seven sites, and cancer incidence or mortality for four sites. Positive associations between T2DM and six cancers reached strong or highly suggestive evidence. We found eight MR studies assessing the association of genetically predicted T2DM and seven and eight studies assessing the association of genetically predicted fasting insulin or fasting glucose concentrations, respectively, upon site-specific cancers. Positive associations were found between genetically predicted T2DM and fasting insulin and risk of six cancers. There was no association between genetically predicted fasting plasma glucose and cancer except for squamous cell lung carcinoma. We found cancer. were identified predicted and fasting insulin cervical
Case Studies in Physiological Renormalization of Skin in Traumatic, Irradiation, Autoimmune, and Aging Conditions using S2RM Stem Cell Released Molecules Enhances Healing and Reduces Pain

Wounds, aging, and autoimmune conditions of the skin involve a disruption of skin homeostasis, especially a disruption of proteostasis. In this study we used S2RM technology, a proprietary combination of stem cell released molecules from multiple types of skin stem cells, to renormalize homeostasis of the skin, including a renormalization of proteostasis. Dramatic reductions in scarring, pain, redness, and inflammation, more rapid and complete wound healing, and an overall enhancement of the appearance of the skin were achieved in a number of skin conditions. Prevention of radiation dermatitis was achieved by concurrent topical administration of S2RM during radiation treatment. The current study demonstrates that simple topical application of S2RM technology is a powerful means to renormalize homeostasis of the skin and remediate and prevent a number of skin indications.
Factors Influencing Long Term Survival in Metastatic Castration Resistant Prostate Cancer Patients: a Spanish Multicentre Experience Therapy Oncology

Background: Cabazitaxel is approved as second line treatment for metastatic castration resistant prostate cancer (mCRPC) after docetaxel failure. However, it is difficult to establish which patients will reach benefit. In this study, we aimed to analyze retrospectively clinical characteristics for cabazitaxel long responding mCRPC patients. Patients and methods: Observational, multicentric, retrospective study. All consecutive mCRPC patients receiving at least 10 cabazitaxel cycles were included from 19 centres in Spain. A descriptive analysis was performed. Overall survival (OS) was analyzed using a Kaplan-Meier model with 95% confidence intervals. Results: 81 patients were included. The median age was 64.29 years, Gleason ≥8 in 63.9% patients, visceral involvement in 78.8%, 42.5% of patients had bone metastases, disease-related symptoms were present in 51.8% patients. The number of events at this cut-off point of the study is 66. Median time to progression to previous docetaxel was 5.3 months. Up to 38.09% of the patients had had a time to progression to prior docetaxel longer than 20 months. Cabazitaxel was well tolerated, being asthenia main adverse event. Median OS was 26.9 months (95% CI: 16.7; 37.2). For those patients with Gleason ≤ 7, median OS reached 29.3 months, versus 21.6 months for Gleason ≥ 8, (p=0.4). There were no differences based on presence of symptoms and visceral metastases. However, there was a trend to a longer survival in those patients who had received previous docetaxel for a more extended period (28.6 months for 3-6 docetaxel months compared to 21.6 in < 3 months). Conclusion:
Terminal Virtualization for Mobile Services

–Terminal virtualization focuses on applying Information Technology (IT) virtualization technology to the terminals to realize the full or parts of terminal functions extension or migration to other devices on the network, such as resource reducing, information sharing, data synchronization, etc. It is becoming increasingly clear that more and more features of terminal virtualization and mobile computing on the edge will be used in practice. However, some issues are raised with terminal virtualization, such as security, privacy, Quality of Service (QoS), efficient transmission, computation/functions offloading management, etc. In this paper, after analyzing above issues, a mobile terminal virtualization framework is proposed and considered to be implemented in terminal Operating System (OS) and transparent to users.
Institutional Knowledge at Singapore Management University Decision Support for Assorted Populations in Uncertain and Congested Environments

This research is motivated by large scale problems in urban transportation and labor mobility where there is congestion for resources and uncertainty in movement. In such domains, even though the individual agents do not have an identity of their own and do not explicitly interact with other agents, they effect other agents. While there has been much research in handling such implicit effects, it has primarily assumed de- terministic movements of agents. We address the issue of decision support for individual agents that are identical and have involuntary movements in dynamic environments. For instance, in a taxi ﬂeet serving a city, when a taxi is hired by a customer, its movements are uncontrolled and depend on (a) the customers requirement; and (b) the location of other taxis in the ﬂeet. Towards addressing decision support in such problems, we make two key contributions: (a) A framework to represent the decision problem for selﬁsh individuals in a dynamic population, where there is transitional uncertainty (involuntary movements); and (b) Two techniques (Fictitious Play for Symmetric Agent Populations, FP-SAP and Soft- max based Flow Update, SMFU) that converge to equilibrium solutions. We show that our techniques (apart from providing equilibrium strategies) outperform “driver” strategies with respect to overall availability of taxis and the revenue obtained by the taxi drivers. We demonstrate this on a real world data set with 8,000 taxis and 83 zones (representing the entire area of Singapore).
Global patterns of Rhododendron diversity

Aim: Understanding the evolution of the latitudinal diversity gradient (i.e. increase in species diversity towards the tropics) is a prominent issue in ecology and biogeography. Disentangling the relative contributions of environment and evolutionary history in shaping this gradient remains a major challenge because their relative importance has been found to vary across regions and taxa. Here, using the global distributions and a molecular phylogeny of Rhododendron , one of the largest genera of flowering plants, we aim to compare the relative contributions of contemporary environment, evolutionary time and diversification rates in generating extant species diversity patterns. Location: Global. Time period: Undefined. Major taxa studied: Rhododendron . Methods: We compiled the global distributions of all Rhododendron species, and constructed a dated molecular phylogeny using nine chloroplast genes and seven nuclear regions. By integrating these two datasets, we estimated the temporal trends of Rhododendron diversification, and explored the global patterns of its species diversity, net diversification rates, and species ages. Next, we reconstructed the geographical ancestral area of the clade. Finally, we compared the relative contribution of contemporary environment, time-for-speciation, and diversification rates on the species diversity pattern of Rhododendron . Results: In contrast to the predictions of the time-for-speciation hypothesis, we found that although Rhododendron originated at a temperate latitude, its contemporary species diversity is highest in the tropics/subtropics, suggesting an into-the-tropics colonization for this genus. We found that the elevated diversification induced by heterogeneous environmental conditions in the tropics/subtropics shapes the global pattern of Rhododendron diversity. Main conclusions: Our findings support tropical and subtropical mountains as not only biodiversity and endemism hotspots, but also as cradles for the diversification of Rhododendron . Our study emphasizes the need of unifying ecological and evolutionary approaches in order to gain comprehensive understanding of the mechanisms underlying the global patterns of plant diversity.
FORMULATION DEVELOPMENT OF OLMESARTAN MEDOXOMIL SOLID SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM

is carried out to assess its capability to disperse into emulsion and the size of resulting globules to categorize them as SMEDDS. It is carried by using a standard USP dissolution apparatus 2 (Paddle Type). 1 ml of each formulation is added to 500 ml of o water at 37 ± 0.5 C and the paddle is rotated at 50 rpm. On titration with water the SMEDDS formulation forms a mixture or gel which is of different type (given in table 15) depending upon which the in vitro performance of formulation can be assessed Robustness on dilution Robustness to dilution was studied by diluting liquid SMEDDS formulation, 100 and 1000 times with various media like distilled water and 0.1 N HCl and checked out any phase separations or precipitation of drug even after 12 hrs of storage, that formulation is considered as robust to dilution. Olmesartan medoxomil (OLM) is a novel selective angiotensin II receptor blocker USFDA approved drug for the treatment of hypertension. The oral bioavailability of OLM is 26% in healthy humans due to low solubility in water. The aim of the present investigation was to develop a self-microemulsifying drug delivery system (SMEDDS) to enhance the solubility of OLM. The screening study of OLM with different oils, surfactants and co-surfactants was done. Out of study optimized batch was converted in to solid freeze dried powder using 2% w/v mannitol as cryoprotcatant by lyophilization technique. This freeze dried powder shown good ﬂow properties. The in vitro dissolution shown that about 99.28±0.013% of the drug is released within 45 min in freeze dried Solid-SMEDDS, while plain drug showed only 37.88±0.025% and marketed tablet shown only 58.31±0.015 % dissolution at the end of 45 min. The in vitro dissolution studies indicate that formulation of OLM in the form of freeze dried powder enhances the dissolution properties. ABSTRACT