Miracle-dz/UniFAR-FTUs huggingface dataset:
Th e induced mutation techniques in combination with plant cell , tissue and organ culture have abundant prospective approach in in vitro breeding programs for major crop plants

Th e genus Gossypium belongs to the Malvaceae family and consists of 45 species of diploids and fi ve species of allotetraploids (Percival et al. 1999). Cotton is an important cash crop (white gold) and is cultivated in 70 countries, with more than Abstract Purpose : The purpose of the investigation was to induce somaclonal variations by gamma rays (GR), ethylmethane sulphonate (EMS) and sodium azide (SA) during in vitro organogenesis of cotton. Materials and methods : The shoot tip explants were irradiated with 5 – 50 Gray (Gy) GR (Cobalt 60), 0.5 – 5.0 mM EMS and SA separately, and inoculated on Murashige and Skoog (MS) medium fortifi ed with plant growth regulator (PGR) for organogenesis. The plantlets with well-developed root systems were acclimatized and transferred into the experimental fi eld to screen the somaclonal variations during growth and development. Results : The number of somaclonal variations was observed in growth of irradiated/treated shoot tips, multiplication, plantlet regeneration and growth in vitro and ex vitro. The lower doses/ concentrations of mutagenic treatments showed signifi cant enhancement in selected agronomical characters and they showed decreased trends with increasing doses/concentrations of mutagenic agents. Conclusions : The results of the present study revealed the infl uence of lower doses/concentrations of mutagenic treatments on in vitro and ex vitro growth of cotton plantlets and their signifi cant improvement in agronomical characters which needs further imperative stability analysis. The present observations showed the platform to use lower doses/concentrations of mutagenic agents to induce variability for enhanced agronomical characters, resistant and tolerant cotton varieties.
2013 : a year of change for Eating and Weight Disorders-Studies on Anorexia , Bulimia , and Obesity

ED/INDEXED IN POPULAR CONTENT WITHIN THIS PUBLICATION 2011 Impact Factor 0.628 READ THIS JOURNAL ON SPRINGERLINK FOR AUTHORS AND EDITORS SERVICES FOR THE JOURNAL ALERTS FOR THIS JOURNAL Get the table of contents of every new issue published in Eating and Weight Disorders Studies on Anorexia, Bulimia and Obesity. Your E-Mail Address Please send me information on new Springer publications in Psychiatry. Current Issue Aims and Scope Submit Online Open Choice Your Way to Open Access Instructions for Authors Conflict of Interest Disclosure Form (pd. Author Academy: Training for Authors Copyright information Contacts Download Product Flyer Shipping dates SUBMIT HOME MI SPRINGER COLECCIONES SERVICIOS EDITORIALES SOBRE NOSOTROS Advanced Search Eating and Weight Disorders Studies on Anorexia, Bulimia and Obesity Volume 18, Issue 1, March 2013 ISSN: 1124-4909 (Print) 1590-1262 (Online) In this issue (16 articles)
Analysis of recurrent neural networks for short-term energy load forecasting

Short-term forecasts have recently gained an increasing attention because of the rise of competitive electricity markets. In fact, short-terms forecast of possible future loads turn out to be fundamental to build efficient energy management strategies as well as to avoid energy wastage. Such type of challenges are difficult to tackle both from a theoretical and applied point of view. Latter tasks require sophisticated methods to manage multidimensional time series related to stochastic phenomena which are often highly interconnected. In the present work we first review novel approaches to energy load forecasting based on recurrent neural network, focusing our attention on long/short term memory architectures (LSTMs). Such type of artificial neural networks have been widely applied to problems dealing with sequential data such it happens, e.g., in socio-economics settings, for text recognition purposes, concerning video signals, etc., always showing their effectiveness to model complex temporal data. Moreo.
Golgi-associated ATPase GABARAPL 1 ( GEC 1 ) associates with autophagic vesicles

GABARAPL1 (GEC1) associates with autophagic vesicles Fatima Zahra Chakrama, Stéphanie Seguin-Py, Jaclyn Nicole Le Grand, Annick Fraichard, Régis Delage-Mourroux, Gilles Despouy, Valérie Perez, Michèle Jouvenot & Michaël Boyer-Guittaut To cite this article: Fatima Zahra Chakrama, Stéphanie Seguin-Py, Jaclyn Nicole Le Grand, Annick Fraichard, Régis Delage-Mourroux, Gilles Despouy, Valérie Perez, Michèle Jouvenot & Michaël Boyer-Guittaut (2010) GABARAPL1 (GEC1) associates with autophagic vesicles, Autophagy, 6:4, 495-505, DOI: 10.4161/auto.6. 4.11819 To link to this article: http://dx.doi. org/10.4161/auto.6. 4.11819
The potential for non-invasive brain stimulation to improve function after amputation

Abstract Purpose: Lower limb amputee rehabilitation has traditionally focussed on restoration of gait and balance through use of prosthetic limbs and mobility aids. Despite these efforts, some amputees continue to experience difficulties with mastering prosthetic mobility. Emerging techniques in rehabilitation, such as non-invasive brain stimulation (NIBS), may be an appropriate tool to enhance prosthetic rehabilitation outcomes by promoting “normal” brain reorganisation and function. The purpose of this review is to highlight the potential of NIBS to improve functional outcomes for lower limb amputees. Methods: To demonstrate the rationale for applying NIBS to amputees, this study will first review literature regarding human motor control of gait, followed by neurophysiological reorganisation of the motor system after amputation and the relationship between brain reorganisation and gait function. We will conclude by reviewing literature demonstrating application of NIBS to lower limb muscle representations and evidence supportive of subsequent functional improvements. Results: Imaging, brain stimulation and behavioural evidence indicate that the cortex contributes to locomotion in humans. Following amputation both hemispheres reorganise with evidence suggesting brain reorganisation is related to functional outcomes in amputees. Previous studies indicate that brain stimulation techniques can be used to selectively promote neuroplasticity of lower limb cortical representations with improvements in function. Conclusions: We suggest NIBS has the potential to transform lower limb amputee rehabilitation and should be further investigated. Implications for Rehabilitation Despite extensive rehabilitation some amputees continue to experience difficulty with prosthetic mobility Brain reorganisation following amputation has been related to functional outcomes and may be an appropriate target for novel interventions Non-invasive brain stimulation is a promising tool which has potential to improve functional outcomes for lower limb amputees
Ayurveda and Plant-based Interventions for Cancer Management: A Systematic Review

Introduction: A resurgence of interest in Ayurveda, other traditional systems of medicine, and complementary and alternative medicine (CAM) has resulted from the preference of many consumers for products of natural origin. The potential benefits of plant-based medicines could lie in their high acceptance by patients, and efficacy and safety. The most prevalent users of traditional medicine are individuals who have refractory conditions and nonlife-threatening conditions that may be chronic viz. neurological disorders, arthritis, etc. The second-largest group of users is those struggling with chronic, potentially life-threatening diseases, such as cancer and human immunodeficiency virus/acquired immunodeficiency syndrome, etc. Both groups turn to Ayurveda and traditional system of medicine for a variety of reasons, such as management as the main treatment option and improved immune functioning, overall functioning, and quality-of-life (QoL) by coping with side effects from conventional therapies, and to relieve symptoms related to their illness. The upsurge in use of traditional system among cancer patients warrants evidence of safety and effectiveness for these interventions as concomitant to conventional cancer therapy.
Lymphoma Changes in the Diagnosis and Treatment of Low Grade Lymphoma Patients in Germany : Years 2006-2009

Today’s treatment options for indolent lymphoma and chronic lymphocytic leukemia (CLL) range from watch & wait, immunochemotherapy up to allogeneic transplantation. Here we describe changes in the presentation, diagnosis and treatment of indolent lymphoma and CLL that occurred in Germany between the years 2006 and 2009. Two nation-wide surveys which were conducted sequentially in the fourth quarter of 2006 and 2009 in Germany included cohorts of patients with indolent lymphoma and CLL in whom a therapeutic decision was made at representative sample of institutions (university hospitals (UH), non-university hospitals (NH) or office-based hematologists (OH)) within a defined reporting period. Data on disease history and treatment were collected and verified. Data from 576 patients from 46 centers in Q4/2006 were compared with data from 521 patients from 57 centers in Q4/2009. The subpopulation of elderly patients ≥ 70 years of age and the number of patients with comorbidities increased substantially from 39% to 55% and 47% to 65%, respectively. L eu k L ym ph om a D ow nl oa de d fr om in fo rm ah ea lth ca re . c om b y M em or ia l U ni ve rs ity o f N ew fo un dl an d on 0 8/ 03 /1 4 Fo r pe rs on al u se o nl y.
Research on the Output Characteristics of Microfluidic Inductive Sensor

This paper focuses on the output characteristic of the microfluidic inductive sensor. First the coil-metal particle system model is established from Maxwell’s equations. Then series solution is achieved by solving partial differential equation. Finally the numerical simulations and physical experiments are compared on particle feature, particle size, excitation frequency, coil turns, and coil density. The experiments coincide well with the simulations.
Impact of uncertain geology in constrained geophysical inversion

The integration of geological modelling, petrophysics and geophysics in a single inversion scheme is a complex and powerful strategy for solving challenges faced in geoscientific resource exploration. Probabilistic geological modelling and geophysical inversion are non-linear processes that show various degrees of sensitivity to uncertainty in input measurements. Using field geological measurements from the Mansfield area (Victoria, Australia) and synthetic geophysical data, we present a synthetic case study investigating the impact of geological uncertainty on constrained joint geophysical inversion. We investigate the influence of uncertain geological measurements on geologically constrained inversion through a sensitivity analysis to uncertainty in orientation data. Probabilistic geological models used to define constraints for geophysical joint inversion are obtained through a Monte-Carlo based uncertainty estimation (MCUE) method. We simulate a broad range of possible cases through a parameter sweep on uncertainty levels in geological measurements to provide a reference for practitioners. The analysis and comparison of the results at varying uncertainty levels show that results can be grouped into two main categories. For the highest uncertainty levels, significant portions of the models retain the characteristic features of geologically unconstrained inversions. Meanwhile, below a threshold in uncertainty level, inversion benefits from the interaction of geophysical data and geologically conditioned constraints. In such cases, inverted models are improved compared to both the geological modelling alone and geologically unconstrained inversion. The conclusion of this work is that knowledge of this threshold is critical for the interpretation of results and decision making because it indicates whether the datasets provide enough information to take advantage of the complementarities between geological modelling and geophysical inversion. Knowledge of this threshold can also support decision making pertaining to inversion strategies and geological field data collection.
What is the Nature and Social Norm within the Context of In-Group Favouritism?

In-group favouritism behaviour is observed everywhere around the world and previous research has shown that this behaviour is also easily triggered in a laboratory in various contexts. However, little is known about why different magnitudes of in-group favouritism are observed across societies. In this paper, we use a new allocation experiment to examine the nature of social norms within the context of in-group favouritism behaviour. In this experiment, a decision-maker has to decide only once how to allocate a fixed amount of resource between each of the three members of her own group and each of the three members of the out-group, whilst the decision- maker's own payoff is not affected by her decision. Three treatments are implemented: in the first treatment, only the members of the in-group can punish the decision-maker. In the second treatment, only the members of the out-group can punish the decision-maker. Finally, in the third treatment, only an independent third-party observer can punish the decision-maker. The aim of these treatments is to test whether there is a prevailing social norm which dominates the behavioural standard within the context of in-group favouritism and whether this mechanism varies across different subject pools, namely Thailand and the UK. Compared to a baseline treatment with no punishment opportunity, we observed that among the Thai subjects in-group favouritism significantly increased once the in-group members were given the opportunity to punish the decision-maker. The threat of punishment from a third-party punisher also increased in-group favouritism in Thailand. However, when only the out-group members had the opportunity to punish, no change in in-group favouritism behaviour was observed. On the contrary, within the British subject pool, when the out-group members had the opportunity to punish the decision-maker, we observed a decline in in-group favouritism as well as a marked shift towards an equitable outcome. The threats of punishments from the in-group members and the third-party, on the other hand, did not have any impact on in-group favouritism behaviour in the UK. The results suggest that within the Thai subject pool, there appears to be a prevailing `in-group bias norm' which is strongly enforced within and outside the group. Within the UK subject pool, however, it is less clear what the prevailing norm is. Whilst the threat of punishment from the out-group members who directly lose out from favouritism behaviour appeared to significantly reduce this behaviour, an uninvolved third-party was not willing to incur a cost to punish this behaviour. This interesting result indicates two possible explanations: first, in-group favouritism, in contrast to selfish or opportunistic behaviour, may not considered as a strong enough violation of a social norm; and second, the norm of egalitarianism within the context of favouritism may still be `evolving'.
While efforts to effect behavioral change are often concentrated during pregnancy when smoking cessation interventions are moderately success

Growth Models of Maternal Smoking Behavior: Individual and Contextual Factors Elizabeth A. Mumford & Weiwei Liu To cite this article: Elizabeth A. Mumford & Weiwei Liu (2015) Growth Models of Maternal Smoking Behavior: Individual and Contextual Factors, Substance Use & Misuse, 50:10, 1261-1273, DOI: 10.3109/10826084.2014. 998234 To link to this article: http://dx.doi. org/10.3109/10826084.2014. 998234
Due to rapid changes in endothelial function ( early contraction followed by a rapid loss of function ) , microthrombi occur by activation of the clotting system leading to changes in blood rheology and causing organ failure due to misperfusion

The endothelial integrity, as mechanical barrier against microorganisms and as natural “anticoagulant”, is crucial for physiologic organ function. Systemic activation of the endothelium upon inflammation, sepsis, and septic shock is always ending in blood–tissue barrier disruption. With increasing dysfunction, uncontrolled clotting activation, capillary microthrombi formation, tissue edema, local hypoxia, and ischemia are initiated. This in turn enhances a vicious circle leading to multiple organ failure and death. Therefore, biomarkers reflecting this special compartment may help in the early detection of systemic inflammation and its complications. This review provides an overview of the most important endothelial biomarkers and their possible use in sepsis.
Title : Place and grid cells in a loop : implications for 1 memory function and spatial coding 2 Abbreviated title : Place and grid cells in a loop 3

Author contributions: C.R. -C. designed research; C.R. -C. performed research; C.R. -C. contributed unpublished reagents/analytic tools; C.R. -C. and A.B. T. analyzed data; C.R. -C. and A.B. T. wrote the paper. Conflict of Interest: The authors declare no competing financial interests. We thank John Lisman, Marco Idiart, Paul Verschure and David Redish for critical discussions. The authors received financial support from the Brazilian Agencies CAPES, through the Science Without Borders program, and CNPq. Simulations were performed on supercomputers from the Brain Institute and Digital Metropolis Institute at the Federal University of Rio Grande do Norte (Natal, Brazil) and from the Centro Nacional de Supercomputação (CESUP) at the Federal University of Rio Grande do Sul (Porto Alegre, Brazil). Correspondence must be addressed to César Rennó-Costa at Digital Metropolis Institute, Federal University of Rio Grande do Norte, Brazil, Av. Capitão-Mor Gouveia, 3733, 59075-050, Natal, RN, Brazil. E-mail: cesar@imd.ufrn. br Cite as: J. Neurosci ; 10.1523/JNEUROSCI.3490-16.2017
Evolutionarily stable dispersal with pattern formation in a mutualist–antagonist system

Question: How does the evolution of dispersal distance affect the persistence, distribution, and population dynamics of a mutualist–antagonist system capable of endogenous pattern formation? Modelling approach: We let dispersal distance evolve within an individual-based model involving an obligate plant–pollinating seed parasite pair and a parasitoid that preys upon pollinator larvae. The model incorporates demographic parameters for ovule production, pollinator oviposition, pollinator and parasitoid visitation rates, in addition to background mortality probabilities for each of the three species. A corresponding non-spatial mathematical model verifies our representation of the interspecific dynamics. Key assumptions: Individuals move over a homogeneous underlying environment with dispersal distances drawn from probability distribution kernels. Each species is subject to density-dependent reproduction. Pollinators and parasitoids make multiple visits per time step that are Poisson distributed. Conclusions: Dependent on demographic parameter values, there is a spectrum of outcomes, including: (1) runaway selection for increased dispersal distance resulting in homogeneous distributions of all three species; (2) an evolutionarily stable state with pattern formation and metapopulation-like dynamics; and (3) rapid extinction of one or more species. Interestingly, a weak relaxation of the obligacy between the plants and the pollinators erodes the evolutionarily stable state with pattern formation. We argue that this dependence upon and sensitivity to obligacy may explain the lack of empirical observations of endogenous pattern formation in nature.
DEVELOPMENT OF LOAD CELL FOR FORCE MEASUREMENT USING MICRO-ELECTROMECHANICAL SENSOR (MEMS)

MEMS piezoresistive strain sensors are more favorable and attractive due to a number of key advantages such as high sensitivity, low noise, better scaling characteristics, low cost and their ability to have the detection electronics circuit further away from the sensor or on the same sensing board. Moreover, they have high potential for monolithic integration with low-power CMOS electronics. Furthermore, piezoresistive strain sensors need less complicated conditioning circuit. The objective of this work is to develop a load cell for measure of a force using MEMS sensor. A decision of support platform for serving as the elastic transmission of the sensor system is presented. The integrated system design including a carrier platform and MEMS sensor is achieved using Finite Element Method (FEM). A computer simulation of the mechanism and the determination of the transfer function is provided.
A Structural Estimation of the CES Preferences and Linear Labor Supply: The Case of Prime-Age Males in Japan

The tax simulation studies in Japan have necessarily relied on arbitrary sets of preference parameters due to the paucity of the empirical estimates. Motivated by this state of the art, we estimate the labor supply function and preference parameters for Japanese prime-age males, allowing for the complex Japanese income tax system and taking advantage of a large microdata set we obtained for this study. We employ two versions of the method of maximum likelihood. One is the celebrated Hausman method which assumes a linear labor supply function (Hausman 1979). The other is the method proposed by Zabalza (1983), which takes advantage of an explicit specification of the CES preferences. We have examined several estimation patterns and calculated elasticities over the whole or sub-samples of observations. While the sample averages of uncompensated elasticities are estimated between 0.06 -- 0.21, those of compensated counterparts result in higher ranges (0.08 -- 1.39) due to rather large negative estimates for the income effects. It may be interesting to point out that the compensated elasticities tend to be higher in the CES case (0.41 -- 1.39) than the Hausman case (0.08 -- 1.12) despite the fact that the former is immune from the MaCurdy critique (MaCurdy et al. 1990).
Extraction Monitoring Using Microdialysis and Quantification by Skin Iontophoretic Delivery of Acyclovir : Intradermal Drug

The objective of this study was to investigate the effect of iontophoresis on the intradermal and transdermal delivery of acyclovir using hairless rat skin on a vertical Franz diffusion cell. In this study, cathodal iontophoretic delivery of acyclovir from a pH 11 formulation was explored. The effects of time of iontophoresis (10 min, 1 h, and 4 h) and current density (0.2, 0.3, and 0.5 mA/cm) on skin permeation were examined. In vitro dermal microdialysis was performed to identify the drug depot formed in the dermis during iontophoresis. Acyclovir delivery into the receptor compartment was not influenced by current density or duration of current application. However, greater drug levels were delivered into the skin as a function of time of current application to form a drug depot. These results were further confirmed by in vitro dermal microdialysis in which higher drug levels were observed in dialysate in the 4 h iontophoresis group due to higher drug levels delivered into the skin layers as compared to 1 h iontophoresis group. Short duration iontophoresis enhanced acyclovir delivery into the skin layers rapidly and thus may be beneficial to improve treatment for cold sores (herpes labialis infection). Microdialysis could be used as a tool to simultaneously monitor drug levels in the tissue’s interstitial fluid in real time in an in vitro setting.