Miracle-dz/UniFAR-FTUs huggingface dataset:
Sensing threshold control for fair coexistence of heterogeneous systems in open spectrum

A critical problem in open-spectrum communications is fairness with respect to the coexistence of heterogeneous systems with different resource units and traffic models. In addition, the sensing performances of different systems can also lead to unfair resource utilization between systems. To address this problem, we derive a continuous-time Markov chain model to show the effect of sensing performance on system coexistence. The analysis derived from this model is then used as the basis for a sensing threshold control (STC) scheme to achieve fairness. The proposed STC determines the sensing threshold for each system as a way of balancing resource utilization among systems, while guaranteeing target detection probability. Numerical results on the amount of resource utilization by each system demonstrate that the proposed STC achieves a full degree of fairness.
Purpose in life is associated with physical activity measured by accelerometer

Previous research has shown that purpose in life, the belief that one’s life is meaningful and goal-directed, is associated with greater engagement in self-reported physical activity. The purpose of this study was to examine the relationship between purpose in life and accelerometer-measured physical activity. Community volunteers (N = 104) completed measures of purpose in life and potential confounds and wore accelerometers for three consecutive days. Purpose in life was positively associated with objectively measured movement, moderate to vigorous physical activity, and with self-reported activity. These relationships were largely unchanged after controlling for potential confounds. These results suggest that purpose in life is a reliable correlate of physical activity.
Predictive diagnostic of chronic allograft dysfunction using urinary proteomics analysis.

BACKGROUND Kidney transplant Chronic Allograft Dysfunction (CAD), a major cause of long-term graft failure, is currently diagnosed at a late and irreversible stage by graft biopsies. Our goal was to identify predictive urinary biomarkers of CAD before renal lesions appeared by analysis of the urine proteomic profile. METHODS/METHODS: Twenty-nine urinary samples withdrawn three months post-transplant were analyzed by SELDI-TOF technology. CAD development was evaluated by serum creatinine level and confirmed by allograft biopsy one year after transplantation. Comparison of protein profile of both groups revealed 18 biomarkers predictive of CAD occurrence. RESULTS The biomarker demonstrating the highest diagnostic performance was a protein of 8860 Da that predicted CAD with a sensitivity of 93% and a specificity of 65%. Moreover combination of these biomarkers in two multivariate analyses improved the diagnostic potential of CAD. Relevance of these individual biomarkers and a decisional algorithm constituted of 3 proteins was confirmed in an independent cohort of patients with undetermined CAD status one year post-transplant. CONCLUSIONS These non invasive biomarkers, detected as soon as three months post-grafting, allowed identification of patients who would develop CAD as late as 4 years after graft. Systematic measurement of these biomarkers would greatly improve the management of immunosuppressive therapy of kidney grafted patients.
Distribution and abundance of nearctic–neotropical songbird migrants in a forest restoration site in southern Costa Rica

Many ecological relationships that are inherently reciprocal are often studied from one perspective only (Agrawal et al. 2007). One example is the interaction between tropical forests and nearctic-neotropical migratory songbirds (hereafter migrants). Several studies have determined that some migrant populations are limited by conditions at their tropical wintering grounds in Central America, South America and the Caribbean (Marra et al. 1998, Mills 2006); however, the ecological role of migrants in these tropical forests is poorly understood.
Use of the Quick Dementia Rating System (QDRS) as an Initial Screening Measure in a Longitudinal Cohort at Risk for Alzheimer’s Disease

The Quick Dementia Rating System (QDRS) and Clinical Dementia Rating Scale (CDR) assess global cognitive and functional decline. We evaluated whether the shorter QDRS was a valid screen for problems identified by the CDR in individuals with minimal clinical abnormalities. Agreement between QDRS-Global and CDR-Global was assessed for 54 participants from the Wisconsin Registry for Alzheimer’s Prevention. Resource-savings achieved by adopting an “administer CDR-only-if-QDRS-Global>0” approach were estimated based on 238 subsequent participants. Agreement statistics (concordance = 88.9%) supported use of the QDRS as an initial informant report and modifying center protocol to administer CDRs only when QDRS>0 reduced CDR assessments by 79.8%.
Malignant pheochromocytoma of the urinary bladder: Effectiveness of radiotherapy in conjunction with chemotherapy

Abstract A 34‐year‐old Japanese man with malignant pheochromocytoma of the bladder underwent surgical resection and chemoradiotherapy for a local recurrence of lymph node metastasis. Radiotherapy seemed to be effective, indicated by the growth inhibition of the irradiated tumor, decreases in serum and urinary catecholamine levels and a clinical improvement in the refractory stage of the combined chemotherapy.
Ligand loading at the surface of an optical biosensor and its effect upon the kinetics of protein–protein interactions

Optical biosensors are finding increasing use in the determination of kinetic and equilibrium constants for a variety of biomolecular interactions. Usually these biosensors require one biomolecule, the ligand, to be covalently attached to a hydrogel matrix which itself is bonded to the sensing surface. The ligands partner, the ligate, then binds from solution resulting in a measurable change in response which the instrument records as a function of time. Although in many cases, optical biosensors are used in order to obtain parameters that relate to interactions in solution, it is becoming clear that measurements involving the interaction of ligate with immobilized ligands on surfaces require careful experimental design. Here we report on how the density of ligand loading within the hydogel matrix affects the measured interaction kinetics. It is found that crowding of ligand within this matrix results in a significant reduction in the measured association rate constant, with a corresponding effect in the calculated overall affinity. However, measurements at low ligand loadings show association rate constants that are comparable to those measured in solution. Clearly, where this comparison is required, it is important to perform measurements under such conditions. © 1997 John Wiley & Sons, Ltd.
THE IMPACT OF ENTERPRISE PERFORMANCE MANAGEMENT ON MANAGEMENT CONTROL

Enterprise Performance Management (EPM) integrates ideas from Performance Management with Business Intelligence, to make actual performance information available in real-time to the relevant stakeholders. EPM uses a separate data management level to ‘harvest’ data from the operational processes and supply it to Business Intelligence applications, such as planning, dashboards, scorecards, reporting and analysis. The paper shows the theoretical capabilities of EPM systems to support five different types of management control, ranging from hierarchical and centralised to more democratic and autonomous methods. Based on an analysis of a range of secondary case descriptions, including some presented at a key vendor’s user group event, supplemented with conversations with some of these users, the papers gives some ideas on how these capabilities are currently used in practice. In particular it looks at whether the use of EPM Systems is related to changes in management control towards more democratic methods and empowerment.
Socratic Learning: Augmenting Generative Models to Incorporate Latent Subsets in Training Data

A challenge in training discriminative models like neural networks is obtaining enough labeled training data. Recent approaches use generative models to combine weak supervision sources, like user-defined heuristics or knowledge bases, to label training data. Prior work has explored learning accuracies for these sources even without ground truth labels, but they assume that a single accuracy parameter is sufficient to model the behavior of these sources over the entire training set. In particular, they fail to model latent subsets in the training data in which the supervision sources perform differently than on average. We present Socratic learning, a paradigm that uses feedback from a corresponding discriminative model to automatically identify these subsets and augments the structure of the generative model accordingly. Experimentally, we show that without any ground truth labels, the augmented generative model reduces error by up to 56.06% for a relation extraction task compared to a state-of-the-art weak supervision technique that utilizes generative models.
TGF- b 1 and ﬁbroblast growth factor-1 modify ﬁbroblast growth factor-2 production in type II cells

TGF- b 1 and ﬁbroblast growth factor-1 modify ﬁbroblast growth factor-2 production in type II cells. Am J Physiol Lung Cell Mol Physiol 279: L1038–L1046, 2000. —Fibroblast growth factor (FGF)-2, which stimulates DNA synthesis by type II cells in the lung, has been shown to be regulated by transforming growth factor (TGF)- b 1, an important inﬂammatory cytokine, in vascular epithelium. The goal of this study was to determine if FGF-2 production by alveolar type II cells is modulated by TGF- b 1 or FGF-1, which also stimulates DNA synthesis by type II cells. Isolated rat type II cells were exposed to 0–40 ng/ml of TGF- b 1 or 0–500 ng/ml of FGF-1 in serum-free medium for 1–5 days. With a speciﬁc immunoassay, signiﬁcant increases of FGF-2 protein in type II cell lysates to levels above those in control cells were achieved after 1 day of exposure to 100 ng/ml of FGF-1 and after 3 days of treatment with 8 ng/ml of TGF- b 1. Similarly, transcripts for FGF-2 were dramatically increased above those in control cells with TGF- b 1 or FGF-1, as were those for FGF receptor-1. These results demonstrate important regulatory links between FGF-2 and both TGF- b 1 and FGF-1 in the alveolar epithelium that could contribute to the regulation of normal cell
Activation of the Phagocyte NADPH Oxidase Protein p 47 phox PHOSPHORYLATION CONTROLS SH 3 DOMAIN-DEPENDENT BINDING TO p 22

Activation of phagocyte NADPH oxidase requires interaction between p47 and p22. p47 in resting phagocytes does not bind p22. Phosphorylation of serines in the p47 C terminus enables binding to the p22 C terminus by inducing a conformational change in p47 that unmasks the SH3A domain. We report that an arginine/lysine-rich region in the p47 C terminus binds the p47 SH3 domains expressed in tandem (SH3AB) but does not bind the individual Nterminal SH3A and C-terminal SH3B domains. Peptides matching amino acids 301–320 and 314–335 of the p47 arginine/lysine-rich region block the p47 SH3AB/p22 phox C-terminal and p47 SH3AB/p47 phox Cterminal binding and inhibit NADPH oxidase activity in vitro. Peptides with phosphoserines substituted for serines 310 and 328 do not block binding and are poor inhibitors of oxidase activity. Mutated full-length p47 with aspartic acid substitutions to mimic the effects of phosphorylations at serines 310 and 328 bind the p22 proline-rich region in contrast to wild-type p47. We conclude that the p47 SH3A domain-binding site is blocked by an interaction between the p47 SH3AB domains and the C-terminal arginine/lysine-rich region. Phosphorylation of serines in the p47 C terminus disrupts this interaction leading to exposure of the SH3A domain, binding to p22 , and activation of the NADPH oxidase.
Aliso: A Journal of Systematic and Floristic Botany Aliso: A Journal of Systematic and Floristic Botany Wood Anatomy of Buddlejaceae Wood Anatomy of Buddlejaceae

Quantitative and qualitative data are presented for 23 species of Buddleja and one species each of Emorya, Nuxia, and Peltanthera. Although crystal distribution is likely a systematic feature of some species of Buddleja, other wood features relate closely to ecology. Features correlated with xeromorphy in Buddleja include strongly marked growth rings (terminating with vascular tracheids), narrower mean vessel diameter, shorter vessel elements, greater vessel density, and helical thickenings in vessels. Old World species of Buddleja cannot be differentiated from New World species on the basis of wood features. Emorya wood is like that of xeromorphic species of Buddleja. Lateral wall vessel pits of Nuxia are small (2.5 ILm) compared to those of Buddleja (mostly 5-7 ILm). Peltanthera wood features can also be found in Buddleja or Nuxia; Dickison's transfer of Sanango from Buddlejaceae to Ges neriaceae is justified. All wood features of Buddlejaceae can be found in families of subclass Asteridae such as Acanthaceae, Asteraceae, Lamiaceae, Myoporaceae, Scrophulariaceae, and Verbenaceae. Wood anatomy of Buddlejaceae relates to species ecology and size of wood sample, and is not useful in demonstrating that Buddlejaceae are closer to any particular one of these families; such evidence must be sought in molecular data and elsewhere.
Association between harmful oral habits and the structures and functions of the stomatognathic system: perception of parents/guardians.

Purpose To verify the occurrence and associate the presence and duration of harmful oral habits with the structures and functions of the stomatognathic system. Methods This is a cross-sectional, exploratory study. Participants' participation was formalized by the signing of an Informed Consent Form. The non-probabilistic sample comprised 289 children aged one to 12 years assisted at a Family Health Strategy unit. The data were obtained through a questionnaire to identify harmful oral habits applied to the children's parents and/or guardians. The results were considered at 5% level of significance. The statistical analyses were performed using the SPSS 19.0 software and the chi-squared association test was employed to investigate the categorical variables. Results The breastfeeding rate found was 85%; however, only 32.4% of the children were exclusively breastfed until six months of age. The most prevalent habits and those currently maintained were use of conventional bottle (28.62%) and conventional pacifier (23.18%). Significant correlation (p=0.001) was found between keeping the mouth open and oral and oronasal breathing. The presence of habits such as using orthodontic bottle (p=0.016) and orthodontic pacifier (p=0.001) was associated with the breathing mode reported. Habit duration was associated with the perception of changes in speech (p=0.046) and with malocclusion (p=0.014). Conclusion The presence and duration of harmful oral habits were associated with the perception of changes in the structures and functions of the stomatognathic system regarding occlusion, breathing, and speech, accounting for a significant portion of the demand for rehabilitation.
Investigating a High Frequency DC/DC Converter with Soft-Switching Technology

This paper studies boost zero-voltage-switching (ZVS) multi-resonant converter (MRC). Compared with the hard switching converter, it has many virtues such as high efficiency and low radiated EMI emission. Both the hard-switching and the soft-switching boost converters are modeled with state-space averaging method and discrete time mapping modeling method respectively. Simulation results verify the proposed model.
Constitutive and Nitrogen Catabolite Repression-sensitive Production of Gat1 Isoforms*

Background: GAT1 transcription is nitrogen-responsive, whereas Gat1 isoforms (IsoA, IsoB) are produced constitutively. Results: IsoA/B initiate at different methionines. Gln3-dependent IsoA/B production is unresponsive to nitrogen, whereas Gat1M1-S233 peptide production is nitrogen-responsive. Conclusion: Wild type and Gat1M1-S233 protein production is nonparallel. Significance: This is the first instance of Gln3-dependent protein production failing to be nitrogen-responsive, suggesting additional level of Gat1 regulation. Nitrogen catabolite repression (NCR)-sensitive transcription is activated by Gln3 and Gat1. In nitrogen excess, Gln3 and Gat1 are cytoplasmic, and transcription is minimal. In poor nitrogen, Gln3 and Gat1 become nuclear and activate transcription. A long standing paradox has surrounded Gat1 production. Gat1 was first reported as an NCR-regulated activity mediating NCR-sensitive transcription in gln3 deletion strains. Upon cloning, GAT1 transcription was, as predicted, NCR-sensitive and Gln3- and Gat1-activated. In contrast, Western blots of Gat1-Myc13 exhibited two constitutively produced species. Investigating this paradox, we demonstrate that wild type Gat1 isoforms (IsoA and IsoB) are initiated at Gat1 methionines 40, 95, and/or 102, but not at methionine 1. Their low level production is the same in rich and poor nitrogen conditions. When the Myc13 tag is placed after Gat1 Ser-233, four N-terminal Gat1 isoforms (IsoC–F) are also initiated at methionines 40, 95, and/or 102. However, their production is highly NCR-sensitive, being greater in proline than glutamine medium. Surprisingly, all Gat1 isoforms produced in sufficient quantities to be confidently analyzed (IsoA, IsoC, and IsoD) require Gln3 and UASGATA promoter elements, both requirements typical of NCR-sensitive transcription. These data demonstrate that regulated Gat1 production is more complex than previously recognized, with wild type versus truncated Gat1 proteins failing to be regulated in parallel. This is the first reported instance of Gln3 UASGATA-dependent protein production failing to derepress in nitrogen poor conditions. A Gat1-lacZ ORF swap experiment indicated sequence(s) responsible for the nonparallel production are downstream of Gat1 leucine 61.
A polymorphism in the growth hormone (GH)-releasing hormone (GHRH) receptor gene is associated with elevated response to GHRH by human pituitary somatotrophinomas in vitro.

A previous study has suggested that a G to A base change at position 169 of the GHRH-receptor gene in human somatotrophinomas is a mutation and confers hypersensitivity to GHRH. The alternative base converts codon 57 from GCG to AGC, resulting in replacement of alanine (Ala) with threonine (Thr). In the present study, two of five human GH-secreting somatotrophinomas were found to possess the codon 57 AGC sequence. The GCG allele was also detected, indicating heterozygosity. However, the patients' normal blood-derived DNA also yielded the same sequence pattern, indicating that the Ala --> Thr amino acid change is a normal polymorphism, and not a somatic mutation. Nevertheless, in vitro, the tumors possessing the Ala --> Thr amino acid change responded very strongly to GHRH in terms of cAMP formation, being increased 40- and 200-fold, in comparison to the 2-fold increases by tumors without the alternative GHRH-receptor sequence. Likewise, the in vitro response of GH secretion to GHRH was elevated. One of the two tumors with the alternative Thr residue, and the highest responder to GHRH, possessed a gsp mutation, despite the fact that these defects are thought to reduce responsiveness to GHRH. These results fail to confirm that the GCG --> AGC at codon 57 of the GHRH-receptor gene is a mutation, but do support the concept that the alternative form with Thr confers increased sensitivity to GHRH.
DETC 98 / MECH-5870 NATURALLY-TRANSITIONING RATE-TO-FORCE CONTROL

The Naturally-Transitioning Rate-to-Force Controller ( NTRFC) for manipulators is presented. In free motion rate control is provided, while in contact the same rate commands are proportional to the force exerted on the environment by the manipulator. The transition between free motion and stable contact with the environment requires no changes in control mode or gains and hence is termed natural. The NTRFC has been experimentally implemented and shows great promise. This paper demonstrates the NTRFC concept and provides a basis for its modeling and design.
Phytochemical Analysis of Leave Extract of Nyctanthes arbortristis

Nyctanthes arbor-tristis is commonly known as Night-flowering Jasmine, Coral Jasmine and Parijat. The present studies attempts Phytochemical activity of leaves extract of Nyctanthes arbortristis. The crude powder extracts of the leaves of the above plants were taken for the study. Screening of phytochemical of Nyctanthes arbortristis for the presence of tannins, flavonoids, terpenoids, saponins, steroids, carbohydrates, Cardiac glycosides, alkaloids, proteins, using standard methods. Phenolic compounds, tannins, cardiac glycosides, carbohydrates, Cardiac glycosides, proteins and alkaloids were present in Nyctanthes arbortristis. Anthraquinone glycosides and flavonoids were absent.
Ratio between Epstein-Barr viral load and anti-Epstein-Barr virus specific T-cell response as a predictive marker of posttransplant lymphoproliferative disease1

Background. Posttransplant lymphoproliferative disease (PTLD) is closely linked to primary Epstein-Barr virus (EBV) infection and a defect of EBV specific cellular immunity is supposed to be the basis of PTLD. However, EBV load is so far the only marker proposed to evaluate PTLD risk, and no study has investigated the role of specific anti-EBV T lymphocytes (EBV-TL). Methods. We therefore prospectively measured the EBV-TL by enzyme-linked immunospot (elispot) assay, in correlation to EBV load by real-time quantitative PCR and lymphoproliferation occurrence in 45 liver transplanted children. Results. EBV load at the time of primary infection was high in all patients irrespective to subsequent emergence of PTLD. Seven patients developed PTLD, all of them following primary EBV infection. All seven had low EBV-TL (<2/mm3) associated with high viral load (>25,000 copies/&mgr;g DNA). Both parameters can be combined in a 100% positive predictive index. Healing from lymphoma was characterized by rapid EBV-TL increase concomitant to decreasing viral load. EBV-TL follow-up helped to adapt immunomodulation. No patient had PTLD whenever EBV-TL were above 2/mm3. Conclusions. We conclude that high viral load is systematic in patients who underwent primary EBV infection and is indicative of the PTLD risk only if there is low concomitant cellular immune response. Healing from PTLD requires modulation of immunosuppression, and appearance of EBV-TL.
Clinical and microbiological features of persistent or recurrent nongonococcal urethritis in men.

Nongonococcal urethritis, the most common sexually transmitted disease among heterosexual men in the United States, affects at least two million men each year [1, 2]. Chlamydia trachomatis causes ^40^0 of these cases, and Ureaplasma urealyticum is implicated in another 15^020(7o, but the cause of remaining cases is obscure [3]. The response to antibiotics by these men is greatly affected by whether a causative organism can be isolated. Ninety percent and 70^0 of cases of nongonococcal urethritis associated with C trachomatis and U. urealyticum, respectively, respond to antibiotic therapy [4], whereas when neither organism is isolated, ^OVo of cases persist or relapse within six weeks of treatment [4, 5]. Overall, 30(7o of patients treated for nongonococcal urethritis will have persistent or recurrent symptoms. Thus, we estimate that some 600 000 men develop the syndrome of persistent or recurrent urethritis annually in the United States. These men are subjected to repeated diagnostic evaluations, and although an infectious etiology has not been established, they often are treated with multiple courses of antibiotics. We initiated this study to better define the clinical, epidemiological, and microbiological features of persistent or recurrent nongonococcal urethritis in men.