Miracle-dz/UniFAR-FTUs huggingface dataset:
Dietary L -Carnitine Enhances the Lymphatic Absorption of Fat and (cid:1) -Tocopherol in Ovariectomized Rats 1

This study was conducted to determine whether the feeding of dietary L -carnitine (CN) improves the intestinal absorption of fat and (cid:1) -tocopherol ( (cid:1) TOH) in ovariectomized (OX) rats. OX adult rats were weight-matched and assigned to 2 groups fed a modiﬁed AIN-93G diet containing (cid:1) TOH-stripped soybean oil without ( (cid:1) CN) or with ( (cid:2) CN) supplemental CN at 150 mg/kg diet. At 5 wk, each rat with a lymph cannula was infused intraduodenally at 3.0 mL/h with a lipid emulsion consisting of 565 (cid:2) mol triolein labeled with 14 C ( 14 C-OA), 3.6 (cid:2) mol (cid:1) TOH, and 396 (cid:2) mol sodium taurocholate in 24 mL PBS buffer. Lymph was collected hourly for 8 h and analyzed for lipids. The lymphatic absorption of (cid:1) TOH for 8 h in (cid:2) CN rats (899 (cid:3) 201 nmol) was higher ( P (cid:4) 0.05) than in (cid:1) CN rats (587 (cid:3) 92 nmol). The absorption of 14 C-OA in (cid:2) CN rats (53.5 (cid:3) 4.0% dose/8 h) also was increased ( P (cid:4) 0.05) compared with (cid:1) CN rats (47.6 (cid:3) 5.0% dose/8 h). Lymph ﬂow did not differ between the groups. When bile was diverted but with infusion of sodium taurocholate, the lymphatic absorption of lipids did not differ. The present study provides evidence that dietary CN enhances the rates and amounts of lymphatic absorption of (cid:1) TOH and fat in OX rats. Our ﬁndings suggest that dietary CN may inﬂuence the process of lipid packaging and absorption by the enterocyte in OX rats, and may explain in part the increased status of (cid:1) TOH in CN-fed animals. J. Nutr. 135: 753–756, 2005.
TRANSITION TO THE NEW LEASE ACCOUNTING MODEL (IFRS 16) AND COMPANIES’ PERFORMANCE EVIDENCE FROM ITALIAN LISTED COMPANIES

The paper presents an empirical analysis on the implementation of the new lease accounting model provided by IFRS 16. It takes into consideration the theoretical framework related to off-blanche sheet leases and the application of the methodological approaches that provided controversial results about the potential effects on companies’ financial statement and performance deriving from the leases capitalization. More specifically, by analyzing the transition period from the IAS 17 to IFRS 16, this paper aims to measure the effective impacts resulting from the implementation of the new lease accounting model requirements on companies’ financial structure, economic and financial performance and on market reactions. The findings presented in the empirical section enrich the academic debate on lease accounting and harmonization and, they are of a great interest also for practitioners, regulators and policy makers.
Chameleon: The Gist of Dynamic Programming Languages

—Dynamic programming languages, such as JavaScript and PHP, are widespread and heavily used. They provide very useful “dynamic” features, like run-time type inference, dynamic method calls, and built-in dynamic data structures. This makes it hard to build static analyzers, for automatic errors discovery. Yet, exploiting harmful behaviors in such programs, especially in web applications, can have signiﬁcant impacts. In this paper, we present Chameleon, a core programming language summarizing the main features of the dynamic programming paradigm. Chameleon can be useful in deﬁning, testing and comparing static analyses, aiming at preventing bugs and errors in programs written in dynamic programming languages. With Chameleon, static analysis experts could deﬁne and test control mechanisms without the burden to take in consideration the technical details characterizing a speciﬁc real-world programming language.
Full focal plane simulations

We present the 8th Full Focal Plane simulation set (FFP8), deployed in support of the Planck 2015 results. FFP8 consists of 10 ﬁducial mission realizations reduced to 18144 maps, together with the most massive suite of Monte Carlo realizations of instrument noise and CMB ever generated, comprising 10 4 mission realizations reduced to about 10 6 maps. The resulting maps incorporate the dominant instrumental, scanning, and data analysis e ﬀ ects; remaining subdominant e ﬀ ects will be included in future updates. Generated at a cost of some 25 million CPU-hours spread across multiple high-performance-computing (HPC) platforms, FFP8 is used for the validation and veriﬁcation of analysis algorithms, as well as their implementations, and for removing biases from and quantifying uncertainties in the results of analyses of the real data.
Irradiation of low energy ions damage analysis on multilayers

Impacts of low energy He+ ions on reflectivity and stability of EUV multilayers is investigated in this work. Combination of X-ray reflectivity, grazing incidence EUV reflectivity near Silicon edge, and theoretical ion irradiation damage analysis can explain the degradation of ML performances. It is found that MLs irradiation of 4 keV helium ions degrades reflectivity performances with much more impact on grazing incidence mirrors. The proposed method can also regain changes in optical properties due to the irradiations of low energy ions.
Nonsteroidal Anti-inflammatory Drug use is Associated with Incident Hypertension in Ankylosing Spondylitis

Objective: Nonsteroidal anti-inflammatory drugs (NSAIDs) increase blood pressure and potentially cardiovascular burden, which may limit their use in ankylosing spondylitis (AS). Our objective was to determine the association of NSAID use with incident hypertension in a longitudinal AS cohort. Methods: Adults with AS were enrolled in a prospective cohort study of patient outcomes and examined every 4–6 months. Hypertension was defined by patient-reported hypertension; antihypertensive medication use; or, on two consecutive visits, systolic blood pressure ≥ 140 mm Hg or diastolic ≥ 90 mm Hg. Continuous NSAID use was dichotomized based on the validated NSAID index. We assessed the association of NSAID use as a time-varying exposure with the incidence of hypertension using Cox proportional hazards models. Results: Of the 1282 patients in the cohort, 628 patients without baseline hypertension had at least one year of follow up, and were included in the analysis. Of these, 72% were male, the mean age at baseline was 39 ± 13 years, and 200 used NSAIDs continuously. On follow-up, 129 developed incident hypertension. After controlling for other variables, continuous NSAID use was associated with a hazard ratio (HR) of 1.12 for incident hypertension (95% CI, 1.04–1.20), compared to non-continuous or no use. The association did not differ in subgroups defined by age, body mass index, biologic use, or disease activity. Conclusion: In our prospective, longitudinal AS cohort, continuous NSAID use was associated with 12% increased risk for the of incident hypertension, as compared to non-continuous no
Preconditioned iterative solution of the 2D Helmholtz equation

Using a finite element method to solve the Helmholtz equation leads to a sparse system of equations which in three dimensions is too large to solve directly. It is also non-Hermitian and highly indefinite and consequently difficult to solve iteratively. The approach taken in this paper is to precondition this linear system with a new preconditioner and then solve it iteratively using a Krylov subspace method. Numerical analysis shows the preconditioner to be effective on a simple 1D test problem, and results are presented showing considerable convergence acceleration for a number of different Krylov methods for more complex problems in 2D, as well as for the more general problem of harmonic disturbances to a non-stagnant steady flow.
Manometric Biofeedback Eﬀectiveness on Urinary Incontinence and Quality of Life: A Non-Randomized Control Trial

Objectives: This study aimed at examining if a 6-session protocol of tonic-phasic exercises using manometric biofeedback (BFB) is capable of improving quality of life (QoL) and muscular strength in patients with urinary incontinence (UI). Methods: Aprospectivequasi-experimentalbefore-afterstudywasperformedon31patientswithUrinaryIncontinence(UI)referred totherehabilitationdepartmentof SantaCristina’sUniversityhospital,Madrid,Spain. ThestudywasperformedfromJanuarytoDe-cember2016. Atinitialevaluation,aﬃliationof data,predisposingfactors,andtypeof UIwererecorded. Patientsweregivenlifestyle recommendationsandinternationalconsultationonincontinencequestionnaireshortform(ICIQ-SF)/incontinencequality-of-life measure (I-QOL) questionnaires/scales to be fulﬁlled at the beginning/end of treatment. Manometric evaluation was recorded at initial/ﬁnal evaluation by MYOMED ® 932. Manometric-BFB protocol consisted of a 30-minute session of tonic/phasic exercises (15 minutes each), 2 times a week for up to 6 sessions, supervised by a physiotherapist. Results: Mean age was 52 ± 12.1 years. Overall, 96.7% (n = 31) of the participants were females. Maximum and mean strength of pelvicﬂoorcontractionwas24 ± 17.72and4. 9 ± 4.1mmHg,andincreasedsigniﬁcantlyaftertreatmentto35 ± 20.85and7. 45 ± 4.92 mmHg (P < 0.01). The mean ICIQ-SF score was 9.13 ± 5.18 and decreased signiﬁcantly to 6.13 ± 4.75 (P = 0.003). The mean I-QoL score increased signiﬁcantly from 70.33 ± 22.12 to 81.25 ± 16.72 (P = 0.0017). The I-QoL Limiting Behaviour (LB)-subscale raised from 68.38 ± 23.33to80 ± 16.56(P=0.0015);I-QoLPsychosocialImpact(PI)-subscaleincreasedfrom77.43 ± 24.51to80 ± 17.47(p=0.0152);and I-QoL social embarrassment (SE)-subscale incremented from 60.72 ± 22.37 to 74.37 ± 20.86 (P = 0.0007). Conclusions: Manometric-BFB protocol is capable of decreasing UI and to improve QoL and manometric values. This reduced pro-tocolcouldbeappliedtootherpublicandprivateinstitutionsanditcouldhaveaneconomicalimpactonthehealthsystemandon patients’ economy.
LAGRANGIAN AVERAGING FOR THE 1 D COMPRESSIBLE EULER EQUATIONS

We consider a 1-dimensional Lagrangian averaged model for an inviscid compressible ﬂuid. As previously introduced in the literature, such equations are designed to model the eﬀect of ﬂuctuations upon the mean ﬂow in compressible ﬂuids. This paper presents a traveling wave analysis and a numerical study for such a model. The discussion is centered around two issues. One relates to the intriguing wave motions supported by this model. The other is the appropriateness of using Lagrangian-averaged models for compressible ﬂow to approximate shock wave solutions of the compressible Euler equations.
MASTER’S THESIS Recognition of transport means in GPS data using machine-learning methods

Bicycle transport is today one of the most important measures in urban traffic with a view to moving towards more sustainable mobility. Nowadays, smartphones are equipped with Global Positioning System (GPS), which allows cyclists, through smartphone applications, to record their own routes on a daily basis, which is very useful information for traffic and transport planners. The problem appears when there is invalid data due to errors in the measurement or in the GPS signal. The solution is transport mode recognition, which consists of classifying the different existing transport modes on the basis of a set of data. The emerging techniques of machine learning allow the development of very powerful models capable of recognizing means of transport with great effectiveness, based on other studies. Accordingly, this study aims to separate GPS bicycle tracks from the other modes studied (inner-city train (S-Bahn), walk, bike, tram, bus), also classifying the tracks of each means of transport separately. The key contribution of this study is the design and implementation of a machine learning model capable of classifying existing modes of transport in urban traffic in the city of Dresden in Germany. For this purpose, a cascading classifiers model was designed so that in each phase tracks belonging to a different mode are separated, studying in each phase which of the machine learning algorithms used (Decision Tree, Support Vector Machine and Neural Network) has the best performance. The GPS data was collected with the application for smartphone Cyface and from there it was carried out the structuring of data and calculation and selection of features that serve as inputs of the model. To separate inner-city train (S-Bahn), bike and walk tracks (first three phases) accuracy values above 98 % are obtained for any of the mentioned algorithms. For the fourth phase, where the classification between bus and tram tracks is carried out, the performance of the model is not so outstanding, due to its similar characteristics, but nevertheless reaches an accuracy value of 83 % using a Neural Network Multi-layer Perceptron model. The great performance of the model after the training phase allowed its implementation using unlabeled tracks, achieving very good results with an accuracy of 92.6 % in the prediction of the tracks used, making only mistakes in distinguishing between tram and bus tracks.
Estradiol-17 (cid:1) , Prostaglandin E 2 (PGE 2 ), and the PGE 2 Receptor Are Involved in PGE 2 Positive Feedback Loop in the Porcine Endometrium

Before implantation, the porcine endometrium and trophoblast synthesize elevated amounts of luteoprotective prostaglandin estradiol-17 (cid:1) (E 2 ) (PGE 2 ). We hypothesized that embryo signal, E 2 , and PGE 2 modulate expression of key enzymes in PG synthesis: PG-endoperoxide synthase-2 (PTGS2), microsomal PGE synthase (mPGES-1), PGF synthase (PGFS), and PG 9-ketoreductase (CBR1) as well as PGE 2 receptor (PTGER2 and -4) expression and signaling within the endometrium. We determined the site of action of PGE 2 in endometrium during the estrous cycle and pregnancy. Endometrialtissueexplantsobtainedfromgilts(n (cid:1) 6)ond11–12oftheestrouscycleweretreated with vehicle (control), PGE 2 (100 nM), E 2 (1–100 n M ), or phorbol 12-myristate 13-acetate (100 n M , positive control). E 2 increased PGE 2 secretion through elevating expression of mPGES-1 mRNA and PTGS2 and mPGES-1 protein in endometrial explants. By contrast, E 2 decreased PGFS and CBR1 protein expression. E 2 also stimulated PTGER2 but not PTGER4 protein content. PGE 2 enhanced mPGES-1 and PTGER2 mRNA as well as PTGS2, mPGES-1, and PTGER2 protein expression. PGE 2 had no effect on PGFS, CBR1, and PTGER4 expression and PGF 2 (cid:2) release. Treatment of endometrial tissue with PGE 2 increased cAMP production. Cotreatment with PTGER2 antagonist (AH6809) but not PTGER4 antagonist (GW 627368X) inhibited significantly PGE 2 -mediated cAMP production. PTGER2 protein was localized in luminal and glandular epithelium and blood vessels of endometrium and was significantly up-regulated on d 11–12 of pregnancy. Our results suggest that E 2 prevents luteolysis through enzymatic modification of PG synthesis and that E 2 , PGE 2 , and endometrial PTGER2 are involved in a PGE 2 positive feedback loop in porcine endometrium. ( Endocrinology 150: 3823–3832, automated cross-sections in portion of the uterine Five-micrometer paraffin of uterine de-waxed in xylene, and dehydrated using decreasing grades of ethanol. Antigen retrieval performed by pressure cooking in 0.01 M sodium citrate (pH 6) before being placed on the Bond-X machine. Then, en-dogenous peroxidase activity was removed by fixing sections in 3% hydrogen peroxide for 5 min in methanol. Afterward, slides were incubated with rabbit polyclonal anti-PTGER2 (1:1000; Cayman Chemical) antibody for 2 h and treated with the polymer reagent (Vision Biosys-tems) for 15 min. The detection step was performed using 3,3 (cid:5) -diami-nobenzidine tetrahydrochloride for 10 min, and sections were counter- stained in hematoxylin for 5 min. Slides were then removed from the
Assessing the value relevance of accounting data after introduction in Europe

Since 2005, European-listed companies have been required to prepare their consolidated ﬁnancial statements in accordance with the International Financial Reporting Standards (IFRS). We examine whether value relevance increased following the introduction of IFRS, using a sample of 3,721 companies listed on ﬁve European stock exchanges: Frankfurt, Madrid, Paris, London, and Milan. We ﬁnd mixed evidence of an increase in value relevance. However, the inﬂuence of earnings on share price increased following the introduction of IFRS in Germany, France, and the United Kingdom, while the inﬂuence of book value of equity decreased (except for the United Kingdom).
Regional Distribution of (cid:97) -Synuclein Pathology in Unimpaired Aging and Alzheimer Disease

The amygdaloid complex (AC) was found highly vulnerable to (cid:97) -synuclein ( (cid:97) S) pathology in both familial and sporadic Alzheimer disease (AD), and recently, incidental Lewy bodies (LBs) were identiﬁed primarily in the lower brainstem. This challenges the traditional view that the substantia nigra (SN) is the region that is predominately affected in the spectrum of LB disorders. We examined the immunoreactivity of (cid:97) S in the SN, the nucleus basalis of Meynert (nbM), and the AC in 904 subjects with or without concomitant AD pathology. (cid:97) S-positive structures were seen in at least one of the studied brain areas in 121 subjects (13%). The affected regions in the (cid:97) S-positive subjects included the SN (89%), the nbM (73%), and the AC (67%). This study also included 82 sporadic AD patients diagnosed using CERAD criteria. (cid:97) S-positive structures were seen in 32% of the AD patients, with the SN and AC being equally affected. In a few subjects the AC was the only affected area. However, this was not inevitably associated with AD pathology, but was related to cognitive decline. Incidental LBs in the SN were described in the occasional subjects, with no (cid:97) S pathology in the lower brainstem.
Dispersion of Displaying Male Sage Grouse II. The Role of Female Dispersion of Displaying Male Sage Grouse II. The Role of Female Dispersion Dispersion

Summary. The degree to which male sage grouse select lek sites and females select nesting sites to maximize proximity to the other sex was examined by contrasting male dispersions with the dispersions and movements of females in the months preceeding incubation. Wintering females exhibit highly overlapping ranges due to shared use of central refuging areas. In late winter and early spring, females move an average 9 km from wintering areas to select nest sites and males begin occupying leks. Pooled evidence suggests that females select nest sites independently of male dispersion whereas males adjust lek occupation so as to maximize proximity to females. Relevant observations include females visiting nest sites before leks, moving further to select a nest site than to select a lek, and increasing their distance to leks as a result of selecting nest sites. In addition, males avoid leks until females have moved to within 5 km of the arenas, abandon early season leks as local female densities drop, and exhibit dispersions in which mean ratios of females/male are similar across leks. Contrasts between predicted and observed dispersions of males showed that hotspot settlement models are adequate to explain male dispersions on very coarse scales (2 km or greater); on finer scales, habitat preferences of males and tendencies for males to cluster tightly must be invoked in addition to hotspots to explain specific lek sitings.
PRBM_A_309146 563..574

1CAS Key Laboratory of Behavioural Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, People’s Republic of China; 2Department of Psychology, University of Chinese Academy of Sciences, Beijing, 100049, People’s Republic of China; 3School of Transportation, Fujian University of Technology, Fuzhou, 350118, People’s Republic of China; 4School of Psychology, University of Adelaide, Adelaide, SA, 5005, Australia; 5Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, 310058, People's Republic of China Introduction: The COVID-19 pandemic has received broad public attention and has been subject to social media discussion since the beginning of 2020. Previous research has demonstrated that framing could influence perception and behaviors of audience members in the mass media. The question addressed in this paper concerns which information frame is best for reporting negative news (eg, deaths) and positive news (eg, recoveries or cures) related to the outbreak of COVID-19. Methods: During the Spring Festival holidays of 2020 in China, we investigated a sample of 8170 participants’ risk perceptions and emotional responses to the pandemic, and their willingness to forward updates when the information is presented in different frames by using a 2 (domain: living [good news] vs dying [bad news]) × 2 (count: absolute vs relative) × 2 (population base: excluding population base vs including population base) × 2 (content: text-only vs text-plus-graphic) mixed factorial design, with the first factor being a withinsubjects factor and the last three being between-subjects factors. Results: Results indicated that (1) participants were more willing to forward good news (eg, cures) than bad news (eg, deaths); (2) when reporting bad news, the inclusion of the “population base” was effective in minimizing negative emotions; (3) when reporting good news, excluding the “population base” was more effective than including it in order to maximize positive emotions; (4) a text-plus-graphic frame worked better than a text-only frame in lowering the level of risk perception and negative emotions. Discussion: This study is relevant to how individuals and organizations communicate information about this viral pandemic and the probable impact of this news on the general public.
Needle puncture forces in liver blood vessels: towards vein implantation in a liver phantom

Treatment of liver diseases is often done by means of interventional radiology and thereby needles are widely used. These needles are under constant development and therefore needle-tissue interaction data are necessary. The goal of this study is to provide data on needle forces during puncturing of liver blood vessels. These data can be used to mimic blood vessels in a polyvinyl alcohol (PVA) liver phantom, intended for needle development and training purposes. Needle insertion experiments were done on human livers, by puncturing portal veins, hepatic veins, hepatic arteries and liver tissue. The resulting force data show that peak forces are higher during puncturing of liver veins (median=2.20 N, interquartile range=1.46 N to 3.67 N) than during puncturing of liver tissue (median=0.38 N, interquartile range=0.31 N to 0.51 N). The force data were used to find a blood vessel mimicking material. Silicone, with the addition of a mesh fabric, was found to mimic the peak forces of liver veins during needle insertion. A silicone blood vessel was created with use of a 3D-printed blood vessel structure made of water-soluble PVA. The addition of the mesh fabric, furthermore ensures proper bonding between the silicone blood vessel and the PVA liver tissue. The methods described in this study can be used to implant artificial veins in a PVA liver phantom.