Miracle-dz/UniFAR-FTUs huggingface dataset:
Motor coordination, empathy, and social behaviour in school‐aged children

Children with motor coordination problems are known to have emotional difficulties and poor social skills. The current study investigated whether children with poor motor ability have poor emotion recognition skills, and whether these could be linked to problems in social behaviour. It was hypothesized that difficulties in empathic ability might be related to the poor visuo‐spatial processing ability identified in children with developmental coordination disorder (as defined by the American Psychiatric Association). The relationship between motor coordination, emotion recognition, and social behaviour was examined in a sample of 234 children (113 males, 121 females; mean age 9y 7mo, [SD 1y 8mo] age range 6y 8mo to 12y 11mo). From this sample two groups of 39 children each (17 females, 22 males), one group with motor difficulties (mean age 9y 11mo [SD 2y], range 6y 11mo to 12y 11mo) and the other of control children (mean age 10y [SD 1y 11mo], range 6y 11mo to 12y 11mo), matched for age and sex, were compared using a set of six emotion recognition scales that measured both verbal and perceptual aspects of empathic ability. Children with motor difficulties were found to perform more poorly on scales measuring the ability to recognize static and changing facial expressions of emotion. This difference remained even when visuo‐spatial processing was controlled. When controlling for emotion recognition and visuo‐spatial organization, a child's motor ability remained a significant predictor of social behaviour.
Studies on the human adenosine A₁ receptor

The adenosine A{rcub} receptor (AR) is an important G protein-coupled receptor (GPCR) distributed widely throughout the human body and influences many bodily functions. The work presented here investigates in detail the complex heterogeneous nature of agonist binding to the human AR in order to explore receptor-receptor interactions that might be present in oligomeric receptor complexes. The equilibrium and kinetic binding properties of two cell lines expressing the AR at different densities were characterised in detail. This characterisation was compared with that of a series of 47 cell lines expressing different levels of either the AjR-GFP or AR-GFP-Gaj fusion proteins. Equilibrium radioligand saturation and competition experiments provided evidence for a re lationship between the fraction of high affinity agonist binding sites and the level of receptor expression. Cell lines expressing lower levels of the AR showed a greater relative ability to bind agonists with high affinity, and to promote formation of the activated agonist-receptor-G protein ternary complex. The association of Hjagonist to the AjR was biphasic and determined by two different molec ular processes. The association rate constant of the fast component was entirely dependent on the concentration of Hjagonist, whereas dependence of the slow component on concentration was inconclusive. The dissociation of a Hjinverse agonist from the AR was rapid, mono-exponential, complete, and insensitive to GTP. In contrast, the kinetics of H agonist dissociation were complex. Disso ciation of H agonist from the AR-G protein complex was biphasic and dependent on the nature of ligand used to prevent H agonist rebinding. Greater H agonist dissociation was observed in the presence of competing agonist than competing inverse agonist, a novel finding called "agonist- induced agonist dissociation," and was dependent on agonist efficacy. The mechanism behind this is unknown, but appears to involve interactions between high affinity receptor-G protein complexes, possibly in the form of receptor oligomerisation. These interactions are absent at low expression levels and progressively increase with level of expression. Agonist-induced agonist dissociation was observed even in the presence of a high concentration of GTP. Separation of cell membrane fractions by their buoyant density clearly showed the AR-GFP and AR-GFP-Gaj fusion proteins were not found in lower density caveolin-enriched "raft" frac tions. These observations have implications for the nature of the immediate receptor environment and whether the AR and other components of the receptor signalling complex are actively con centrated in regions of the cell membrane. The work presented here describes novel properties of agonist and antagonist binding at the human adenosine Aj receptor and to AjR-GFP and AR-GFP-Go fusion proteins. The ligand dependence of the kinetics of agonist dissociation provides direct evidence for receptor-receptor interactions, such as receptor oligomerisation.
Stable isotope analysis of Humboldt squid prey: Comment on Miller et al. (2013)

ABSTRACT: Miller et al. (2013; Mar Ecol Prog Ser 477:123−134) used bulk stable isotope analysis(SIA) and a Bayesian isotope-mixing model (SIAR) to assess the diet of the Humboldt squid Dosidi-cus gigas in the Northern California Current. Their conclusions starkly contrast decades of foodhabits and other research on this organism. The methods they employed are sensitive to a rangeof assumptions and parameter estimates, and the trophic model they used is confounded by theinteractive effects of movement and diet on D. gigas isotopic values. This is compounded by thesensitivity of the migratory model to critical assumptions of the trophic level of D. gigas (specifi-cally the assumption that large D. gigas are approximately 1 trophic level above copepods), whichare inconsistent with the literature. Therefore, Miller et al.’s (2013) conclusions regarding thecontribution of specific prey to D. gigas in the northern California Current are unsupported.KEY WORDS: Humboldt squid · Dosidicus gigas
Outcome of craniopharyngioma in children: long‐term complications and quality of life

Childhood craniopharyngiomas are histologically benign tumours arising from remnants of Rathke's pouch in the hypothalamic—pituitary region. The two common treatment approaches are primary total resection or limited resection followed by radiotherapy. To study the outcome after a primary surgical approach, we followed 25 consecutive patients (10 females, 15 males) under 16 years of age who were treated in a single institution with a management policy of radical tumour excision (mean age at diagnosis 9 years 2 months, SD 4 years 3 months; range 2 years 9 months to 15 years 11 months). Mean follow‐up after primary surgery was 11 years 3 months (SD 7 years 7 months). Tumour control, and neurological, endocrine, and hypothalamic complications and their impact on health‐related quality of life were assessed (medical follow‐up, semi‐structured interview, and questionnaires). Results of tumour control were generally good, however, local failure was observed in 6 of 25 patients, and severe late‐treatment complications decreased quality of life for many long‐time survivors. Endocrine deficiency occurred in 24/25, visual complications in 16/24, neurological complications in 8/24, obesity in 14/23, increased daytime sleepiness in 6/21, and significant school problems in 10/20. Patients with craniopharyngioma rated their health‐related quality of life as considerably lower than healthy controls; the domains of social and emotional functioning were particularly affected. Parents’ratings were considerably lower than those of the patients. Poor functional outcome was associated with large tumours infiltrating or displacing the hypothalamus, the occurrence of hydrocephalus, and young age at diagnosis, but also with multiple operations due to tumour recurrence. Alternative treatment strategies should be considered, especially in very young patients with large tumours.
A New Emerging Role of Clinical Pharmacist in Radiology DepartmentReporting Errors and Clinical Intervention by Clinical Pharmacist

Radiology department will provide a variety of inpatient and outpatient services. These services use medical imaging such as radiography, computed tomography, magnetic resonance imaging, nuclear medicine, positron emission tomography, and ultrasound. Error in radiology department implies an incorrect interpretation of an imaging study. To improve safety, error-reporting strategies should include identifying errors, admitting mistakes, correcting unsafe conditions, and reporting systems improvements to stakeholders. Reducing errors will improve patient care, may reduce costs and will improve the image of the hospital. To identify reporting errors in CT, MRI and x ray in a tertiary care hospital and assess the role of clinical pharmacist in reducing the reporting errors. In this study patients who were referred to undergo CT scan, MRI and x ray were taken in to the study. Duration of study was 8 months. Patients reports were taken and reporting errors were noted in the respective data collection form reporting errors was identified and analyzed. In the present study very less error reports were identified which shows the regular monitoring of the clinical pharmacist, results in the accurate diagnosis of the patient and accurate treatment plan that reflects the health care practice in a hospital. Error in reports can cause wrong diagnosis and which may result in false treatment plan. So identification of errors in reports by the health care professional (pharmacist) at the basic level before going for final assessment of the condition may improve patient care, reduce healthcare cost and time for re do’s. This also creates a new task for the clinical pharmacist.
Interdependence and Integration among Components of the Airline Scheduling Process: A State-of-the-Art Review

Over the last few decades, the Airline Scheduling Process (ASP) has received an unprecedented attention from airliners and operations research society. Conventionally, the Airline Scheduling Process is decomposed into four sub-problems namelySchedule Generation, Fleet Assignment, Aircraft Routing, and Crew Scheduling which are solved sequentially in order to incorporate tractability and feasibility in the overall process. However, sequential decomposition, by construct, fails to capture the inter-dependencies among these sub-problems. To overcome this limitation, the air transport research society has lately started adopting integrated models for modeling and solving the sub-problems of the ASP. But due to the limited computational power and available technology, researchers are only able to address partial-integration among these sub-problems. This paper thoroughly reviews the ASPs literature particularly in the light of the extent to which the inter-dependence has been explored through integration among its sub-problems. This review paper categorizes the existing literature in one of the 11 possible classes based on varying degree of integration among the sub-problems, and projects the research gap in the integrated airline scheduling which is ought to be bridged towards robust airline scheduling.
Systematic detection of local CH4 emissions anomalies combining satellite measurements and high-resolution forecasts

Abstract. In this study we present a novel monitoring methodology to detect local CH4 concentration anomalies worldwide that are related to rapidly changing anthropogenic emissions that significantly contribute to the CH4 atmospheric budget. The method uses high resolution (7 km × 7 km) retrievals of total column CH4 from the Tropospheric Monitoring Instrument (TROPOMI) onboard the Sentinel 5 Precursor satellite. Observations are combined with high resolution CH4 forecasts (~ 9 km) produced by the Copernicus Atmosphere Monitoring Service (CAMS) to provide departures (observations minus forecasts) close to the native satellite resolution at appropriate time. Investigating the departures is an effective way to link satellite measurements and emission inventory data in a quantitative manner. We perform filtering on the departures to remove the large-scale biases on both forecasts and satellite observations. We then use a simple classification on the filtered departures to detect anomalies and plumes coming from CAMS emissions that are missing (e.g. pipeline or facility leaks), under-reported or over-reported (e.g. depleted drilling fields). Additionally, the classification helps to detect local satellite retrieval errors due to land surface albedo issues.
ASSOCIATIONS OF DGAT1 POLYMORPHISM WITH MILK CHARACTERISTICS IN SLOVAK DAIRY COWS

DGAT1 encodes diacylglycerol O-acyltransferase (EC 2.3.1.20), a microsomal enzyme that catalyzes the final step of triglyceride synthesis. It was shown that the QTL variation is most likely caused by a nonconservative base substitution in the candidate gene DGAT1 changing lysine to alanine (K232A) in the enzyme diacylglycerol O-acyltransferase (DGAT). In particular, the allele encoding the lysine 232 variant proved to be more efficient with regard to milk fat synthesis. The objective of the present study was to determine the allele frequencies and to verify the effects of the two DGAT variants (K232A polymorphism, A and K alleles) on milk production traits in Slovak dairy cows. Samples of 196 dairy cows originating from 61 sires were genotyped for DGAT1 K232A polymorphism (A and K alleles) using the PCR-RFLP technique. The frequencies of DGAT1 alleles were 0.88 (A) and 0.12 (K). The performance data were collected during one season in order to minimize this effect. The overall milk yield (MILK), fat yield (FAT_Y), fat content (FAT_C), protein yield (PROT_Y), protein content (PROT_C) and age at first calving (AGE1) were studied. The effect of DGAT1 polymorphism on fat and protein content in milk was confirmed. Further study is needed for explanation of effect of DGAT1 on the age at first calving. JMBFS / Vašíčková et al. 2013 : 2 (Special issue 1) 2025-2031 2026
Key enzyme activity of nitrogen metabolism and variation of leaf nitrogen assimilation among soybeans with different protein content

Relationships of kernel protein content,glutamine synthetase activity (GSA) and nitrate reductase activity (NRA) were studied using wild,common wild and cultivated soybeans.Results showed that,the NRA (from V6 to R8 stages) and GSA (from R3 to R8 stages) of high-protein wild soybeans were higher than those of others.Moreover,its leaf soluble protein content was also the highest during all stages except R3 stage.Free amino acid contents of wild soybeans were higher before R2 stage,while those of cultivated ones became the highest after R2.The kernel protein content had positive correlations with NRA (during R3 to R8 stages),GSA (during R3 and R8 stages),soluble protein during V3 stage and free amino acid content during V6 stage.No correlation was found between kernel protein content and nitrate-nitrogen content of leaves.
Large‐scale zone‐based evacuation planning, Part II: Macroscopic and microscopic evaluations

A companion paper introduces models and algorithms for large‐scale zone‐based evacuation planning in which each evacuation zone is assigned a path to safety and a departure time. It also shows how to combine zone‐based evacuations with contraflows and impose additional path‐convergence and nonpreemptive constraints. This paper evaluates these algorithms on a real, large‐scale case study, both from a macroscopic standpoint and through microscopic simulations under a variety of assumptions. The results quantify, for the first time, the benefits and limitations of contraflows, convergent plans, and nonpreemption, providing unique perspectives on how to deploy these algorithms in practice. They also highlight the approaches best suited to capture each of these design features and the computational burden they impose. The paper also suggests new directions for future research in zone‐based evacuation planning and beyond in order to address the fundamental challenges by emergency services around the world.
Constraint‐induced movement therapy (CIMT) for infants and toddlers

effect starting at follow up 1 may have limited our ability to detect group differences, 93% vs 67% of the trial for the SPEEDI and Usual care groups respectively. For the TIMP change scores, there was no interaction, but there was a significant Group and Time effect (p = 0.10 and p < 0.0001, respectively, Figure 2). A post-hoc t-test showed a group difference in the TIMP change score during Phase 2 (p = 0.09). Conclusions/Significance: This study provides initial evidence of the efficacy of SPEEDI to increase midline hand use and improve early motor abilities. Collaboration between therapists and parents resulted in infants receiving daily opportunities to advance their motor development. Research is needed on the impact of early behavioral changes on cognition.
Studies on resource characteristics of Salvia miltiorrhiza varieties

Object To study, in terms of ecotype, the resource characteristics of the varieties in national well known genuine herbs of Salvia miltiorrhiza Bge. , S. miltiorrhiza cv. sativa, S. miltiorrhiza cv silcestris and S. miltiorrhiza cv foliolum. Methods By the methods of special survey and systematic selection in the main productive areas, the techniques of dissociating, puring germ plasms and standard operation practice (SOP) were adopted at inpublic nuisances hills. With 3×5 random group arrangement, the variety comparison of special experimental study in a 3 year continuous session and t test were carried out. Results The significant differences (P0 001) of biological character, productivity, disease resistant, and commodity yield of above three herbs were observed. On the other hand, there were the obvious differences of ecoadaptability, plantlet property, pollen granule, chromosome, isoenzyme, and quality. Then the variety resource characteristics were reviewed. Conclusion The variety resource types of S. miltiorrhiza is first established, and the characteristic index system of S. miltiorrhiza in Sichuan Province is set up in variety resources study and productivity characters. S. miltoffhiza cv silcestris is a new of S. miltorrhiza in Sichuan Province with the high quality and yield. The variety resource of S. miltiorrhiza cv foliolum in Sichuan possessing in rich reproductive capacity will be used to fill in the gaps of the production of S. miltiorrhiza in Sichuan Province, which couldn't be cultivated in sexual reproductions. The rejuvenesencece study of traditional S. miltiorrhiza cv sativa should be emphasized. Generally, the above study provides the scientific basis for making the rational development and utilization of S. miltiorrhiza resources, so as to put the GAP production into effect.
The BREV neuropsychological test: Part I. Results from 500 normally developing children

The Battery for Rapid Evaluation of Cognitive Functions (Batterie Rapide d'Evaluation des Fonctions Cognitives: BREV) was designed to provide health professionals with a quick clinical tool for screening acquired and developmental cognitive deficits in children aged 4 to 8 years. The BREV explores oral language in both its expressive and receptive forms, non‐verbal functions, attention, verbal and visuo‐spatial memory, and main learning acquisition. Results of the first phase of validation are presented in this report consisting of internal validity measurements gained by testing 500 normally developing school children (257 females, 243 males; mean age 6 years 7 months, SD 1 year 6 months. The validation provides appropriate values for each of the 17 subtests assessing cognitive functions (oral language, nonverbal abilities, attention and memory, educational achievement) in 10 age groups, from 4 to 8 years of age. All subtests with the same content for any age revealed values which increased significantly with age. Interreliability was tested in a retest for 70 children and scores obtained on retesting correlated significantly with initial values. The BREV is a reliable test with carefully established normative values, appropriate for preschool and school‐age children.
Water Use and Growth of Honey Locust and Tree-of-Heaven at High Root-zone Temperature

Honey locust (Gleditsia triacanthios var. inermis Willd.) and tree-of-heaven [Ailanthus altissima (Mill.) Swingle] sometimes are exposed to high root-zone temperatures in urban microclimates. The objective of this study was to test the hypothesis that seedlings of these species differ in how elevated root-zone temperature affects growth, leaf water relations, and root hydraulic properties. Shoot extension, leaf area, root: shoot ratio, and root and shoot dry weights were less for tree-of-heaven grown with the root zone at 34C than for those with root zones at 24C
Isolation and molecular characterization of Pseudomonas spp. with antagonistic activity against Macrophomina phaseolina

A study was conducted to isolate and characterize bacterial isolates from Rhizosphere soils with potential for suppression of charcoal rot pathogen Macrophomina phaseolina causing charcoal rot maize. Out of 10 bacterial isolates collected from forest rhizosphere soils, 2 isolates were found to be antagonistic to M. phaseolina in in vitro studies. In these best two isolates were molecularly characterized by using 16s rRNA. Data for bacterial antagonists have been deposited under the following accession numbers: MN985505 (Pseudomonas aeruginosa) and MN985650 (Pseudomonas aeruginosa.).
A review of the nematode genus Labiobulura (Ascaridida: Subuluridae) parasitic in bandicoots (Peramelidae) and bilbies (Thylocomyidae) from Australia and rodents (Murinae: Hydromyini) from Papua New Guinea with the description of two new species

The nematode genus Labiobulura Skrjabin & Schikhobalova, presently known from bandicoots (Isoodon Desmarest and Perameles Geoffroy), and bilbies (Macrotis Reid) from Australia and rodents (Leptomys Thomas) from Papua New Guinea is revised. Diagnoses of Labiobulura, Labiobulura (Archeobulura) Quentin and Labiobulura (Labiobulura) Quentin and a key to all species of the genus are given. Five species are redescribed: L. (A.) leptomyidis Smales from L. paulus Musser, Helgen & Lunde, L. (A.) peragale Johnston & Mawson from M. leucura (Thomas), L. (L.) baylisi Mawson from I. macrourus (Gould) and P. nasuta Geoffroy, L. (L.) inglisi Mawson from I. obesulus (Shaw), P. bougainville Quoy & Gaimard and P. gunnii Gray, L. (L.) peramelis Baylis from I. macrourus and two are described as new: L. (A.) perditus from P. bougainville, L. (L.) quentini from I. obesulus and the identification of the hosts determined. The significance of the relationship between the placement of the amphids and cephalic papillae and the labial lobes is discussed and the denticles surrounding the mouth opening in the sub genus Labiobulura are described, both for the first time. There is evidence for host specificity in the Archeobulura with each parasite species limited to a single host species but less so for the Labiobulura with three of five species found in more than one host species.