Miracle-dz/UniFAR-FTUs huggingface dataset:
A Genetic Variant in CDKN2A Gene Predicts the Risk of Developing Cervical Cancer

Background: Cervical cancer is among the most commonly occurring cancers in women. Despite extensive efforts in the identification of prognostic and predictive biomarkers, only a very small number of markers have been identified. Several genetic variants in the 9p21 region have been found to be associated with an increased risk of developing cancers. The aim of present study was to explore the value of a genetic variant (rs10811661) in the CDKN2A in cervical cancer for the first time. Methods: Data in computer-based patient dossiers (CPRs) of Mashhad University of Medical Sciences at Ghaem Hospital were applied to identify cervical cancer patients, between 2014 to September 2017. Sixty-four patients and 493 healthy subjects with no known history of infectious HPV, cancer, or family history of cancer were used. DNA was extracted, followed by genotyping using real-time-PCR. The genotype frequency and allele distribution of cases and controls were analyzed using χ2, t-test or multivariate analyses. Results: Our data showed the genotypic frequency for TT, TC and CC of the CDKN2A locus were 61.6%, 27.7%, 11.1% in the patient group and 70.7%, 25.5%, 3.6% in the healthy control group. Moreover, our data showed that the TT genotype of the rs10811661 polymorphism, using a recessive genetic inheritance model, was associated with an increased risk of cervical cancer (e.g., OR: 1.3, 95% CI: 1.1-2.9, p=0.04). Conclusion: We have demonstrated that patients with a TT genotype for the rs10811661 polymorphism of the CDKN2A gene locus were associated with increased risk of cervical cancer. Further investigations are required in a larger population to explore the value of this gene marker in the management of cervical cancer.
Mesoscopic Solute-Rich Clusters in Olanzapine Solutions

An organic molecule may crystallize in numerous distinct lattices, and the slow and unpredictable transitions between multiple crystal forms are a significant concern in its pharmaceutical application. Recent results indicate that the transformation of olanzapine (OZPN) from anhydrous to hydrate crystals is mediated by mesoscopic solute-rich clusters. Here we demonstrate the existence of such clusters in undersaturated OZPN solutions in purely aqueous and mixed EtOH/aqueous solvents. The clusters occupy about 10–8 to 10–7 of the solution volume and capture ca. 10–7 to 10–5 of the dissolved OZPN. The average cluster radius is steady in time at about 35 nm and independent of the OZPN concentration and the solvent composition, whereas the OZPN fraction captured in the clusters is dictated by the solution thermodynamics. Both behaviors are in dire conflict with classical theories of phase transformation and recent aggregation models. They are, however, consistent with the predictions of a model that assumes t.
Path Analysis: Sociological Examples

Linear causal models are conveniently developed by the method of path coefficients proposed by Sewall Wright. Path analysis is useful in making explicit the rationale of conventional regression calculations. It may also have special usefulness in sociology problems involving the decomposition of a dependent variable or those in which successive experiences of a cohort are measured. Path analysis focuses on the problem of interpretation and does not purpot to be a method for discovering causes. It may, nevertheless, be invaluable in rendering interpretations explicit, self-consistent, and susceptible to rejection by subsequent research.
Metamorphosis of data (small to big) and the comparative study of techniques (HADOOP, HIVE and PIG) to handle big data

Immoderate amount of data is being generated everyday across the world via miscellaneous sources or fields which create issues to the users. Due to this rapid growth, the crucial issue is to analyse the big data with the help of traditional data processing tactics. Structured data is not the peerless but moreover unstructured data and semi-structured data charge up the supplementary consequences to handle this voluminous data. As in this gigantic bulk of data highly advantageous information is hidden which can be good for what ails the individual, group or organization and for adding up to more sophisticated or valuable decisions. So in order to deal with this many new tools and techniques have been excogitated. These tools can analyse the large volume of data being generated at unprecedented speed. This paper shows the comparative study of some of the data analytics techniques which can untangle the big data analytics issues by examining it in more précised manner. The contrast study of Hadoop, Hive and Pig has been illustrated which covers the working of these techniques.
Construction of Recombinant Bioleaching Bacteria Thiobacillus ferrooxidans with Fluoride-Resistant Activity

Thiobacillus ferrooxidans is an important bioleaching bacterium, widely used in leaching, recovery of low-grade metals and environmental bioremediation. In bio-metallurgy industry, fluoride existing in some hard rock uranium deposits in south China severely affects the bacteria viability and inhibit leaching reproduction. In this study, the flr-4 gene that has strong resistance to fluorine ion in Caenorhabditis elegans, was cloned into pET30a vector and expressed in E. coli BL21. the ability of fluoride resistance in E. coli was increased obviously. To increase the fluoride-resistance of bioleaching bacterium T. ferrooxidans strain 1 (T.f1), the flr-4 shuttle recombinant plasmid pJRD215-flr-4 was constructed and transferred into T.f1 by conjugation. pJRD215-flr-4 was stable in T.f1 with more than 70% retention after 50 generations. Recombinant T.f1 was tolerant to fluorine ions and grew well under fluoride (F-) stress especially at F- concentrations ranging from 10 mg/L to 60 mg/L.
The Ship Experiment at the GDT Facility—Concept and Results of Calculations

At present, the Gas Dynamic Trap (GDT) facility of the Budker Institute Novosibirsk is being upgraded. The first stage of the upgrade is the Synthesized Hot Ion Plasmoid (SHIP) experiment. It aims, on the one hand, at the investigation of plasmas which are expected to appear in the region of high neutron production in a GDT based fusion neutron source proposed by the Budker Institute and, on the other hand, at the investigation of plasmas the parameters of which have never been achieved before in magnetic mirrors. In parallel to experimental research at the GDT an Integrated Transport Code System (ITCS) is under development in collaboration with the Forschungszentrum Rossendorf. It is to calculate the relevant physical effects which are connected with neutral gas, background plasma and with the high-energetic ion component inside the central cell of the GDT and later inside the neutron source. This contribution explains the concept of the SHIP experiment and presents the results of first calculations by means of ITCS modules.
ADOPT : Good for sulfonylureas ?

This is an author-created, uncopyedited electronic version of an article accepted for publication in Diabete Care. The American Diabetes Association (ADA), publisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version is available in Diabetes Care in print and online as indicated Ebaa Al-Ozairi, Latika Sibal, and Philip Home, A Diabetes Outcome Progression Trial (ADOPT): Good for Sulfonylureas? Diabetes Care 30:1677-1680, 2007 http://care.diabetesjournals. org/cgi/content/full/30/6/1677 ADOPT: Good for sulfonylureas?
ECG DENOISING USING MODIFIED NON LOCAL MEANS ALGORITHM

: Denoising of the raw signal while keeping the relevant information is one of the important issues in the domain of Electrocardiogram (ECG) analysis. Removal of noise from the desired cardiac signal by using standard filter tends to corrupt the signal of interest. The method proposed in this work is based on a modified version of the Non-Local Means algorithm. NLM algorithm has widely been used for 2D signal processing but has received little significance in 1D signal analysis. The work is done on a modified form of conventional NLM filter is used to denoise raw ECG signal by optimizing the parameters of filter, further a comparison is made between the results of conventional and modified NLM filter.
Effect of Processing on Phenolic Content and Antioxidant Activity of Four Commonly Consumed Pulses in China

Four commonly consumed pulses, faba bean, mung bean, soybean, zauki bean were studied for their total phenolic content and antioxidant activity after germination (12 and 24 h) and pressure cooking. Soybean had the highest total phenolic content (6.89 mg ferulic acid/g flour) whereas azuki bean had the least (2.54 mg/g). All pulses, except azuki bean, showed a significant decrease in total phenolic content after germination. The antioxidant activity of the pulses varied from 10.82 to 36.41% (DPPH radical scavenging activity), which significantly decreased with germination in all pulses except azuki. The total phenolic content highly correlated with the antioxidant activity in the pulses. Cooking lowered the total phenolic content by 12-51% and antioxidant activity by 16-67% in the control and germinated pulses.
Collaboration within the Supply Chain: Perception for the Automotive Industry in Morocco

Based on a periodical of literature on the collaboration stakes within supply chain, this article studies the Moroccan automotive sector. It allows to answer the following questions: Does the Moroccan automotive sector use collaborative practices between the actors? If this is the case, what stakes can we draw for these actors? These are the questions to which we will try to answer from an exploratory empirical research with the help of suppliers, customers and logistic service providers.
Species Diversity of Black Fly in Southeast Asia: Phylogenetic Analysis of Three Subgenera, Asiosimulium, Daviesellum, and Wallacellum, of the Genus Simulium s. l.

Black flies (Diptera: Simuliidae) are distributed worldwide. The biting habits of black flies are known to cause medical and veterinary problems including transmissions of filarial diseases of humans and animals. In Southeast Asia (Thailand, Malaysia, Philippines, and Indonesia), eight subgenera (Asiosimulium, Daviesellum, Gomphostilbia, Montisimulium, Morops, Nevermannia, Simulium s. str., and Wallacellum) of genus Simulium s. l. are known. Of these subgenera, three subgenera (Asiosimulium, Daviesellum, and Wallacellum) are small, endemic only in the Oriental region (except one species of Wallacellum), and recently established. To confirm the subgeneric status, phylogenetic analysis was conducted using mitochondrial 16S rRNA sequences. As results, the three subgenera were clearly separated from other subgenera. Their subgeneric status was confirmed both by phylogenetic analysis and morphological characters.
THE EFFECT OF A FORMIC ACID-BASED PRESERVATIVE ON STRUCTURAL CARBOHYDRATES AND NUTRITIVE VALUE OF LOW DRY MATTER SWEET SORGHUM SILAGES

This study was conducted to evaluate the effects of a formic acid-based preservative (FAP) on the structural carbohydrates and nutritive value of low dry matter sweet sorghum (Sorghum bicolor L. Moench) silages. Sorghum was harvested at the flowering stage of maturity (23.0±0.69% dry matter). The FAP (KemiSile® 2000, Kemira OyjIndustrial Chemicals, Finland) was applied to approximately 2 cm chopped fresh material at 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, and 4.0 ml/kg levels, respectively and ensiled in 1.5 liter anaerobic jars (Le Parfait, France) equipped with a lid that enabled gas release only. The jars were stored at 24±2 oC under laboratory conditions. All jars were opened at the end of the ensiling period (90 days) and sampled for analysis. As a result, the FAP treatment reduced structural carbohydrates such as neutral detergent fiber, acid detergent fiber and lignin, hemicellulose and cellulose contents; however, they increased residual water soluble carbohydrates of silages (P < 0.05). Due to the reduction in structural carbohydrates, the application of FAP increased in situ dry and organic matter degradability of silages (P < 0.05). Most effective level of FAP on sorghum silage was found as 4.0 ml/kg.
Non‐local heat flux application for scrape‐off layer plasma

The non‐local expression proposed by Luciani‐Mora‐Virmont is implemented in a one dimensional fluid model for the scrape‐off layer. Analytical solutions for heat equation are discussed as well as the impact of sheath boundary conditions on the continuity of the temperature profile. The non‐local heat flux is compared to the Spitzer‐Härm heat flux for different collisionality.
Misaligned Accretion and Jet Production

Disk accretion onto a black hole is often misaligned from its spin axis. If the disk maintains a significant magnetic field normal to its local plane, we show that dipole radiation from Lense–Thirring precessing disk annuli can extract a significant fraction of the accretion energy, sharply peaked toward small disk radii R (as R−17/2 for fields with constant equipartition ratio). This low-frequency emission is immediately absorbed by surrounding matter or refracted toward the regions of lowest density. The resultant mechanical pressure, dipole angular pattern, and much lower matter density toward the rotational poles create a strong tendency to drive jets along the black hole spin axis, similar to the spin-axis jets of radio pulsars, also strong dipole emitters. The coherent primary emission may explain the high brightness temperatures seen in jets. The intrinsic disk emission is modulated at Lense–Thirring frequencies near the inner edge, providing a physical mechanism for low-frequency quasi-periodic oscillations (QPOs). Dipole emission requires nonzero hole spin, but uses only disk accretion energy. No spin energy is extracted, unlike the Blandford–Znajek process. Magnetohydrodynamic/general-relativistic magnetohydrodynamic (MHD/GRMHD) formulations do not directly give radiation fields, but can be checked post-process for dipole emission and therefore self-consistency, given sufficient resolution. Jets driven by dipole radiation should be more common in active galactic nuclei (AGN) than in X-ray binaries, and in low accretion-rate states than high, agreeing with observation. In non-black hole accretion, misaligned disk annuli precess because of the accretor’s mass quadrupole moment, similarly producing jets and QPOs.
A Trivariate Causality Test: A Case Study in Cameroon

In this paper, we examine the causal relationship between diesel consumption, CO2 emissions and GDP in Cameroon during the period 1975-2008. Cointegration and vector error-correction modelling techniques are used in this study. ADF tests show that the series, after logarithmic transformation, are non-stationary and integrated of order one.This study finds the presence of a long-run equilibrium relationship between the variables. The results of the Granger-causality tests for time series have been estimated.
THE DETERMINANTS AND EFFECTS OF JICA RICE TECHNOLOGY ADOPTION IN THE SAGNARIGU DISTRICT OF THE NORTHERN REGION, GHANA

This study analysed the adoption of JICA rice production technologies and its effect on output in Sagnarigu District of the Northern Region. A total of 120 respondents from six communities in the Sagnarigu District were randomly selected and interviewed using semi-structured questionnaires. The logit model was used to determine the factors that influenced the adoption of JICA rice production technologies while the propensity score matching was employed to estimate the effect of treatment (adoption) on rice output. The study found that membership to farmer association and fertilizer subsidy positively and significantly influenced adoption of the rice production technologies whereas farm size, access to agricultural extension, use of other improved seed, and household size negatively affected adoption of the rice production technologies. The adoption of technologies led to a significant improvement in rice output. We recommend that farmers be supported to step up their adoption of the rice technologies through the formation of farmer groups as well as the fertilizer subsidization programme, among others. Keywords : Adoption, JICA, Propensity Score Matching, Rice, Technology
Management Problems Encountered with Livestock Guarding Dogs on the University of California, Hopland Field Station

--Guard dogs are being promoted and utilized as effective predator damage control tools under a variety of livestock management conditions. We report our experience over 1 1/2 years with 5 dogs, primarily Anatolian shepherd and Akbash dog breeds. We discuss a number of behavioral and management problems we have encountered, some of which have not previously been reported in the literature. These include chasing vehicles and wildlife, predation on deer ( Odocoileus hemionus columbianus ), and incompatibility of dogs with other predator damage control methods.
In the eye of the beholder? Representations of video surveillance in German public television

This article is based upon an analysis of the commonalities between CCTV and television. Although this article is not meant to contribute to media studies as a science, it will nonetheless use empirical data from diverse TV shows, time periods and regions to show the decisive role television plays in public acceptance and implementation of public surveillance technology, as well as in the construction of suspicion. Additionally, this article considers the technological similarities of CCTV and television by using TV data as a source of ethnographic material to understand the discriminating nature of visual surveillance technologies.
Influence of Water on Tribological Properties of Wood-Polymer Composites

Abstract Utilization of ecological materials for appliances and products is one of the ways to achieve the goal of sustainability.Wood-polymer composites as a cheap, lightweight, durable and esthetic material has gained attention of scientists, engineers and consumers alike. Different kinds of polymeric matrices, plants used as the fillers, chemical of physical modifiers and processing technologies have already been widely studied. Nonetheless, surprisingly few information on Wood-Polymer Composites’ tribology can be found. This paper is an attempt to fill this gap. Polypropylene-and poly(lactic acid)-based composites with varying wood flour content have been analyzed. The Brinell’s hardness and coefficient of friction of the samples have been determined. In order to evaluate the influence of the moisture content on the tribological and mechanical properties of the composites, the samples have also been aged in water. The investigation revealed that polymeric composites filled with wood flour can present favorable coefficient of friction, compared to the neat resins. The results of our study can establish a good starting point for further investigation.
What About the Debt Governance Structure and Stockholders' Interests in Transition Market? Perspectives from Egypt

This study examines the relationship between debt governance structure at three levels (high, medium and low) and firm's performance in the stock market. The debt structure classifies debt into short-term debt and long-term debt at each debt level. The results indicate that in the high debt firms, the short-term debt helps improve the PE ratio. As for the medium debt firms, the results show also that the short-term debt helps improve the market value added. The results of the low debt firms are similar to those of the high debt firms indicating that the short-term debt can be used to improve the PE ratio. The regression characteristics show that with the exception of medium debt in the PE equation, the explanatory power for the other performance measures are relatively high which indicates a relatively high degree of association between both types of debt with the MB and MVA respectively. The overall results show that (1) debt governance structure in Egypt is characterized by the dominance of short-term debt, (2) the latter can be used to improve the firm's performance in the stock market, which shows that the association of interests between short-term debtholders and stockholders is highly likely, and (3) the negative relationships of long-term debt indicate to the presence of an agency problems between long-term debtholders and stockholders. The contribution of this paper is that it shows the extent to which either type of debt can be used to address the debtholder-stockholders agency relationships.
Managing the development of innovation business processes with automated information systems

Mykhaylo Voynarenko, Doctor of Economics, Professor, Emeritus of Science and Technologies of Ukraine, Corresponding Member of the NAS of Ukraine, Vice-rector in Research and Academic Affirs, Khmelnytsky National University (Khmelnytsky, Ukraine); Larysa Dzhuliy, Candidate of Economic Sciences, Associate Professor, Associate Professor of the Accounting, Audit and Taxation Department, Khmelnytsky National University (Khmelnytsky, Ukraine); Olena Kuzmina, Candidate of Technical Sciences, Associate Professor, Associate Professor of the Economic Cybernetics and Information Systems Department, Vinnytsia Trade and Economic Institute of the KNTEU (Vinnytsia, Ukraine); Tetiana Yanchuk, Candidate of Economic Sciences, Associate Professor, Associate Professor of the Marketing Department, Donetsk National University named after Vasyl Stus (Vinnytsia, Ukraine)
Effects of long-term mowing on the fractions and chemical composition of soil organic matter in a semiarid grassland

Abstract. The grassland ecosystem is a significantly important terrestrial carbon pool. Intensive mowing is common to meet the need of increased livestock. However, little information on the quality and quantity of soil organic matter (SOM) under different mowing managements has been documented. In this work, in order to evaluate the impacts of different mowing managements on the quality and quantity of SOM, the fractions and chemical composition of SOM under different mowing managements were determined using traditional fractionation methods and spectroscopy technologies, including advanced nuclear magnetic resonance (NMR) (e.g. cross-polarization magic angle spinning 13C-NMR, CPMAS 13C-NMR) and Fourier-transform infrared (FTIR) based on a 13-year field mowing trial with four treatments: unmown (M0), mowing once every second year (M1/2), mowing once a year (M1) and mowing twice a year (M2). The results showed that compared with M0, M1/2 and M1 significantly enhanced the SOM accumulation and increased the stability of SOM by enhancing humification, while M2 limited SOM accumulation and microbial biomass. Substituted alkyl carbon (C) was the major organic C type in the grassland ecosystem, and it made up over 40 % of the total C. M1/2 and M1 significantly increased stable C functional groups (alkyl C and aromatic C) by degrading labile C functional groups (O-alkyl and carbonyl C) and forming recalcitrant humus, while M2 had opposite effects. The consistent increase in the values of NMR indices reflecting the degradation degree, hydrophobicity and aromaticity of SOM in M1 reflected the fact that M1 had the largest contribution to increasing the stability of SOM, while these values in M2 were similar to those in M0. Significant correlations between different SOM fractions and nitrogen (N) mineralization, and between the contents of different C functional groups and net soil organic nitrogen mineralization or microbial biomass C, indicated that the shifts in SOM fractions and chemical composition were closely related to soil microbial biomass and activity. Therefore, in view of the quality and quantity of SOM and the sustainable development of grassland ecosystems, M1 was the optimal mowing management, while M2 should be avoided in the semiarid grassland.