Miracle-dz/UniFAR-FTUs huggingface dataset:
Association of sociodemographic and lifestyle factors with dietary patterns among men and women living in Mexico City: A cross-sectional study

Background Diet is one of the leading risk factors for non-communicable diseases and is related to sociodemographic and lifestyle factors, including sex. These associations vary across populations. We aimed to investigate which factors are associated with dietary patterns among adults living in Mexico City by sex. Methods We used data from the Mexico City Diabetes Representative Study, a cross-sectional, multistage, stratified, and cluster-sampled survey in Mexico City (n = 1,142; 413 men and 729 women). Dietary information was collected using a semi-quantitative food frequency questionnaire. Foods and beverages were categorized into 23 food groups to identify dietary patterns by cluster analysis. Sociodemographic and lifestyle variables included were self-reported through standardized questionnaires. We assessed the association of sociodemographic and lifestyle factors with dietary patterns through a multinomial logistic model stratified by sex. Results We identified three dietary patterns: basic, prudent, and fast food. Among men and women, higher school attainment was associated with a lower relative probability of having a basic rather than prudent dietary pattern (women: RRR = 0.8, 95% CI: 0.8, 0.9; men: RRR = 0.8, 95% CI: 0.7, 0.9). Divorced or separated men (RRR = 3.8, 95% CI: 1.3, 11.2) and those living with a partner (RRR = 2.6, 95% CI: 1.1, 6.1) had a higher relative probability of consuming a fast food dietary pattern than the prudent one, compared to single men. Men living with a partner (RRR = 3.0, 95% CI: 1.1, 8.6) or working long shifts (RRR = 3.8, 95% CI: 1.3, 11.1) had a higher probability of consuming a basic pattern rather than a prudent one compared to peers. Among women, those with high SES had a lower probability of consuming the “basic” pattern rather than the “prudent” pattern compared to those with low SES. No lifestyle factors were associated to dietary patterns. Conclusions Men living in Mexico City with lower education, age, non-single, and working long hours (i.e., more than the established by the law), and women with lower age, education, and socioeconomic level are prone to adhere to unhealthy diets. These associations are likely to be driven by gender roles.
Identification of solamargine as a cisplatin sensitizer through phenotypical screening in cisplatin-resistant NSCLC organoids

Although Cisplatin (DDP) is a widely used first-line chemotherapy medication, DDP resistance is one of the main causes of treatment failure in advanced lung cancer. Therefore, it is urgent to identify DDP sensitizers and investigate the underlying molecular mechanisms. Here we utilized DDP-resistant organoids established from tumor biopsies of patients with relapsed lung cancers. In this study, we identified Solamargine as a potential DDP sensitizer through screening a natural product library. Mechanically, Solamargine induced G0/G1-phase arrest and apoptosis in DDP-resistant lung cancer cell lines. Gene expression analysis and KEGG pathway analysis indicated that the hedgehog pathway was suppressed by Solamargine. Moreover, Gli responsive element (GRE) reporter gene assay and BODIPY-cyclopamine binding assay showed that Solamargine inhibited the hedgehog pathway via direct binding to SMO protein. Interestingly, Solamargine and DDP showed a synergetic effect in inhibiting DDP-resistant lung cancer cell lines. Taken together, our work herein revealed Solamargine as a hedgehog pathway inhibitor and DDP-sensitizer, which might provide a new direction for further treatment of advanced DDP-resistant lung cancer patients.
The steady state visual evoked potential (SSVEP) tracks “sticky” thinking, but not more general mind-wandering

For a large proportion of our daily lives, spontaneously occurring thoughts tend to disengage our minds from goal-directed thinking. Previous studies showed that EEG features such as the P3 and alpha oscillations can predict mind-wandering to some extent, but only with accuracies of around 60%. A potential candidate for improving prediction accuracy is the Steady-State Visual Evoked Potential (SSVEP), which is used frequently in single-trial contexts such as brain-computer interfaces as a marker of the direction of attention. In this study, we modified the sustained attention to response task (SART) that is usually employed to measure spontaneous thought to incorporate the SSVEP elicited by a 12.5-Hz flicker. We then examined whether the SSVEP could track and allow for the prediction of the stickiness and task-relatedness dimensions of spontaneous thought. Our results show that the SSVEP evoked by flickering words was able to distinguish between more and less sticky thinking but not between whether a participant was on- or off-task. This suggests that the SSVEP is able to track spontaneous thinking when it is strongly disengaged from the task (as in the sticky form of off-task thinking) but not off-task thought in general. Future research should determine the exact dimensions of spontaneous thought to which the SSVEP is most sensitive.
Influence of online comments on clothing impulse buying behavior in mobile short video app live broadcast

Based on elaboration likelihood model (ELM), this paper introduces the central route and peripheral route of online comments and constructs a conceptual model affecting consumers’ clothing impulse buying behavior in live broadcast. A total of 737 questionnaires were collected, and 709 valid questionnaires were used for questionnaire analysis. According to the ELM, there are central route (comment quality and comment comprehensiveness) and peripheral route (comment quantity and commentator credibility) of online comments. The results show that in addition to the commentator credibility, the comment quality, comment comprehensiveness, and comment quantity have a significant positive impact on impulse buying behavior. Fashion involvement plays a moderating role in the relationship between online comments and impulse buying behavior. This paper will provide theoretical support for live broadcast clothing marketing and provide suggestions for the development and design of live broadcast.
Cerebral small vessel disease combined with cerebral collaterals to predict the prognosis of patients with acute large artery atherosclerotic stroke

Background and purpose Besides cerebral collaterals, few studies have examined other additional factors affecting the prognosis of patients with large artery atherosclerotic (LAA) stroke. Our study aims to explore the effect of the cerebral small vessel disease (SVD) and the effects of its interaction with cerebral collaterals on the prognosis of patients with acute LAA stroke. Method Patients aged 18 years or older with LAA stroke within 24 h after stroke onset were consecutively enrolled. The functional outcome was determined using the modified Rankin Scale (mRS) at 3 months after stroke onset. Logistic multivariate analyses were used to identify the risk factors for stroke prognosis. Receiver operating characteristic (ROC) curves were constructed to compare the effects of cerebral collaterals and SVD on predicting the prognosis. Results Of the 274 enrolled patients, 174 (63.50%) were identified as having a favorable prognosis, and 100 (36.50%) were identified as having an unfavorable prognosis. After adjusting for covariates, the logistic regression analysis identified that unfavorable prognosis was related to the total SVD score (Model 1, adjusted odds ratio = 1.73, 95% CI: 1.15–2.61, P < 0.01; Model 2, adjusted odds ratio = 1.85, 95% CI: 1.23–2.79, P < 0.01) and Tan score (Model 1, adjusted odds ratio = 0.38, 95% CI: 0.23–0.64, P < 0.01; Model 2, adjusted odds ratio = 0.52, 95% CI: 0.33–0.82, P < 0.01). Compared with cerebral collaterals (AUC = 0.59; 95% CI: 0.52–0.67; P < 0.01) or SVD (AUC = 0.62; 95% CI: 0.56–0.69; P < 0.01) alone, the combination of collaterals and SVD (AUC = 0.66; 95% CI: 0.59–0.73; P < 0.01) had higher diagnostic value for an unfavorable prognosis, and the optimal sensitivity and specificity were 77.01 and 53.00%, respectively. Conclusions The total SVD burden was related to the prognosis of patients with LAA stroke. Compared with cerebral collaterals or SVD alone, cerebral collaterals combined with total SVD burden are better at predicting the prognosis of patients with acute LAA stroke.
Differentially constrained motion planning with state lattice motion primitives

Robot motion planning with differential constraints has received a great deal of attention in the last few decades, yet it still remains a challenging problem. Among a number of reasons, three stand out. First, the differential constraints that most physical robots exhibit render the coupling between the control and state spaces quite complicated. Second, it is commonly accepted that robots must be able to operate in environments that are partially or entirely unknown; classical motion planning techniques that assume known structure of the world frequently encounter difficulties when applied in this setting. Third, such robots are typically expected to operate with speed that is commensurate with that of humans. This poses stringent limitations on available runtime and often hard real-time requirements on the motion planner. The impressive advances in computing capacity in recent years have been unable, by themselves, to meet the computational challenge of this problem. New algorithmic approaches to tackle its difficulties continue to be developed to this day. The approach advocated in this thesis is based on encapsulating some of the complexity of satisfying the differential constraints in pre-computed controls that serve as motion primitives, elementary motions that are combined to form the solution trajectory for the system. The contribution of this work is in developing a general approach to constructing such motion primitives, given a model of robot mobility. Moreover, the approach allows an unprecedented amount of pre-computation in this domain, which yields a dramatic increase in planning efficiency even for systems with complex kinematics and dynamics. Lastly, the proposed motion primitives are fully compatible with a wide range of planning algorithms and allow such useful techniques as incremental planning and multi-directional search to be used in the context of planning with differential constraints. These ideas are demonstrated and validated on a number of relevant systems, both in simulation and in real experiments. This work promises to enable capable and reliable motion planners with differential constraints, as encountered in many realistic robot systems with practical utility, operating efficiently in cluttered, partially known environments.
Dynamic coupling between the central and autonomic cardiac nervous systems in patients with refractory epilepsy: A pilot study

The heart and brain are reciprocally interconnected and engage in two-way communication for homeostatic regulation. Epilepsy is considered a network disease that also affects the autonomic nervous system (ANS). The neurovisceral integration model (NVM) proposes that cardiac vagal tone, indexed by heart rate variability (HRV), can indicate the functional integrity of cognitive neural networks. ANS activity and the pattern of oscillatory EEG activity covary during the transition of arousal states and associations between cortical and autonomic activity are reflected by HRV. Cognitive dysfunction is one of the common comorbidities that occur in epilepsy, including memory, attention, and processing difficulties. Recent studies have shown evidence for the active involvement of alpha activity in cognitive processes through its active role in the control of neural excitability in the cortex through top-down modulation of cortical networks. In the present pilot study, we evaluated the association between resting EEG oscillatory behavior and ANS function in patients with refractory epilepsy. Our results show: (1) In patients with refractory epilepsy, there is a strong positive correlation between HRV and the power of cortical oscillatory cortical activity in all studied EEG bands (delta, theta, alpha, and beta) in all regions of interest in both hemispheres, the opposite pattern found in controls which had low or negative correlation between these variables; (2) higher heartbeat evoked potential amplitudes in patients with refractory epilepsy than in controls. Taken together, these results point to a significant alteration in heart-brain interaction in patients with refractory epilepsy.
Virome of Rhipicephalus ticks by metagenomic analysis in Guangdong, southern China

Tick-borne viruses (TBVs) have increasingly caused a global public health concern. This study collected Rhipicephalus ticks in Guangdong, southern China to identify RNA viruses. Meta-transcriptome analysis revealed the virome in Rhipicephalus ticks, resulting in the discovery of 10 viruses, including Lihan tick virus, Brown dog tick phlebovirus 1 and 2 in the family Phenuiviridae, Mivirus and Wuhan tick virus 2 in the family Chuviridae, Wuhan tick virus 1 in the family Rhabdoviridae, bovine hepacivirus in the family Flaviviridae, Guangdong tick quaranjavirus (GTQV) in the family Orthomyxoviridae, Guangdong tick orbivirus (GTOV) in the family Reoviridae, and Guangdong tick Manly virus (GTMV) of an unclassified family. Phylogenetic analysis showed that most of these TBVs were genetically related to the strains in countries outside China, and GTQV, GTOV, and GTMV may represent novel viral species. These findings provided evidence of the long-distance spread of these TBVs in Guangdong, southern China, suggesting the necessity and importance of TBV surveillance.
Chromobox 7/8 serve as independent indicators for glioblastoma via promoting proliferation and invasion of glioma cells

Background The chromobox family, a critical component of epigenetic regulators, participates in the tumorigenesis and progression of many malignancies. However, the roles of the CBX family members (CBXs) in glioblastoma (GBM) remain unclear. Methods The mRNA expression of CBXs was analyzed in tissues and cell lines by Oncomine and Cancer Cell Line Encyclopedia (CCLE). The differential expression of CBXs at the mRNA level was explored in The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases with the “beeswarm” R package. The protein expression of CBXs in GBM was further examined on Human Protein Atlas (HPA). The correlations between CBXs and IDH mutation and between CBXs and GBM subtypes were investigated in the TCGA portal and CGGA database with the “survminer” R package. The alteration of CBXs and their prognostic value were further determined via the cBioPortal and CGGA database with the “survival” R package. The univariate and multivariate analyses were performed to screen out the independent prognostic roles of CBXs in the CGGA database. Cytoscape was used to visualize the functions and related pathways of CBXs in GBM. U251 and U87 glioma cells with gene intervention were used to validate the role of CBX7/8 in tumor proliferation and invasion. Proliferation/invasion-related markers were conducted by Western blot and immunostaining. Results CBXs presented significantly differential expressions in pan-cancers. CBX2/3/5/8 were upregulated, whereas CBX6/7 were downregulated at mRNA level in GBM of TCGA and CGGA databases. Similarly, high expression of CBX2/3/5 and low expression of CBX6/8 were further confirmed at the protein level in the HPA. CBX2/6/7 were positively correlated with IDH mutation and CBX1/2/4/5/8 were closely related to GBM subtypes. CBX7 and CBX8 presented the independent prognostic factors for GBM patient survival. GO and KEGG analyses indicated that CBXs were closely related to the histone H3-K36, PcG protein complex, ATPase, and Wnt pathway. The overexpression of CBX7 and underexpression of CBX8 significantly inhibited the proliferation and invasion of glioma cells in vivo and in vitro. Conclusion Our results suggested that CBX7 and CBX8 served as independent prognostic indicators that promoted the proliferation and invasion of glioma cells, providing a promising strategy for diagnosing and treating GBM.
Extended Hyperbola Function Method and Its Application to Nonlinear Equations

An extended hyperbola function method is proposed to construct exact solitary wave solutions to nonlinear wave equation based upon a coupled Riccati equation. It is shown that more new solitary wave solutions can be found by this new method, which include kink-shaped soliton solutions, bell-shaped soliton solutions and new solitary wave.The new method can be applied to other nonlinear equations in mathematical physics.
Optimisation de maillages

In this thesis, a practical approach to isotropic triangle mesh generation is proposed. In 2D as in 3D, the goal is to mesh the interior of a domain that possibly has a complex geometry. The studied approach consists in interleaving Delaunay reﬁnement steps and mesh optimization steps, in order to generate quality graded meshes that satisfy size, shape, topology and approximation user-deﬁned criteria for simplices. Widely used for simulation, ﬁnite element methods need graded meshes composed of well-shaped simplices. Alternatives to usual Delaunay reﬁnement methods are developed. New mesh optimization methods, able to optimize internal and boundary vertices locations and to preserve the input boundary features, including sharp creases, are studied. In 2D, the optimization method is based on the Lloyd iteration and centroidal Voronoi tessellations (CVT). In 3D, a natural extension to optimal Delaunay triangulations (ODT) introduced by Chen that is able to optimize boundary vertices locations, is proposed. Our tetrahedron meshing algorithm is completed with a post-processing step that signiﬁcantly improves the quality of tetrahedra dihedral angles. We ﬁnally give some experimental evidence that interleaving reﬁnement and optimization results in generating meshes of higher quality than usual methods, in terms of simplices angles and number of vertices.
Modified Current Mask Generation (M-CMG): An Improved Countermeasure Against Differential Power Analysis Attacks

It has been demonstrated that encryption device leaks some information, which can be exploited by various attacks such as differential power analysis (DPA). To protect an Advanced Encryption Standard (AES) implementation from DPA without any modification of the cryptographic algorithm, we can use the Current Masking Generation (CMG). The CMG countermeasure consists of stabilizing the power consumption, but it presents some limitations concerning temperature variations and the Early effect. The goal of this paper is to update the CMG to address these problems, evolving to the Modified-Current Masking Generation (M-CMG).
Evolution of ENSO precipitation teleconnections

The El Niño Southern Oscillation (ENSO) is one of the most important climate phenomena on our planet. It affects precipitation globally through aperiodic changes in ocean currents triggered by sea surface temperatures (SSTs) in the equatorial Pacific Ocean. To measure the global impact of ENSO on rainfall, several methods are used, such as correlation analyses. Cross-correlation analyses are typically used to identify linear relationships and their time lags to evaluate teleconnection links. However, standard correlation analyses can produce spurious teleconnections due to indirect links, common drivers, or autocorrelations, biasing interpretability, thus making cause-effect relationships difficult to establish. Moreover, little is known about the extent to which teleconnection maps have changed over the past several decades. Here, in addition to standard correlation analysis, we use the PCMCI+CEN causal discovery approach to reveal the effects of a range of El Niño SST indices on global precipitation amounts across multiple time window to better understand the uniqueness of each ENSO region. By removing confounding effects of different Niño regions on the index regions under analysis, we identified causal relationships with lags of up to 12 months that describe the unique impacts of individual Niño regions. Furthermore, trends in spatial correlation fields between the Oceanic Niño Index (ONI) from the tropical Pacific El Niño region and global precipitation anomalies were determined for lag 0 and quantified with 10-year sliding time windows. The Maritime Continent Region and the Southwest Pacific Region, which are the largest regions anticorrelating with ENSO, showed a waning trend, while the largest positively correlating Central Pacific Region showed only slight fluctuations until 2012, after which a slight decreasing trend was observed. We found that cross-correlation analyses for all El Niño SST indices (Niño 1+2, 3, 4, ONI) for teleconnections at lag -1 (month) yielded the most significant hits (in terms of modes and medians), which are indicative of strong correlations. Causal maps created using the PCMCI+CEN approach partially corroborate ENSO’s previous knowledge of teleconnection maps, but other regions allegedly influenced by ENSO are poorly covered or in some cases not masked at all. Our results demonstrate that although different El Niño SST indices are strongly intercorrelated, regions can be identified that represent very unique characteristics of ENSO events. We expect that our work will help to understand how driving forces in the form of univariate time series can affect the climate in the regions studied, such that expert knowledge can be used to better understand the causes of local influences on climate variables such as temperature, precipitation, or atmospheric pressure. Sliding time windows for correlation analyses or causal map analyses can help assess the extent to which anthropogenic climate change may have played a role in changes in global teleconnections over recent years or decades.
THE READING CIRCLE IN ENGLISH TEACHING DEVELOPMENT: AN EXPERIENCE REPORT IN LETTERS GRADUATION COURSE

: This article aims to describe the experience of the reading circle in English literature (drama) course in Letters graduation at IFCE – Camocim campus, by discussing the importance of the activity as a contribution to the development of English teacher in development. For that, we resorted to the conceptions of reading in Koch (2006) and Marcuschi (2008); cognitive processing in Evans and Green (2006); literacy in Kleiman (2000); and the concepts that underlie the reading circle in literature classes in Cosson (2009; 2014). We describe the methodological path for achieving the readin g circle as a practice of reading activity and as the formation of literary readers, in addition to presenting the resul ts of the survey form applied to students after the sessions. The results obtained agree with the impressions intuitively acquired during the sessions and show possible directions for f uture reading circles in English Literature classes in Language courses. RESUMEN : Este artículo se propone describir la experiencia del círculo lector en la asignatura de Literatura Inglesa (drama) de la licenciatura en Letras en IFCE - campus Camocim, discutiendo la importancia de la actividad como aporte al desarrollo del futuro profesor de inglés. Para eso, recurrimos a las concepciones de lectura de Koch (2006) y Marcuschi (2008); procesamiento cognitivo en Evans y Green (2006); alfabetización en Kleiman (2000); y los conceptos que subyacen al círculo de lectura en las clases de literatura de Cosson (2009; 2014). Se describe el camino metodológico para la consecución del círculo lector, como una práctica de la actividad lectora y la formación de lectores literarios, además de presentar los resultados del cuestionario aplicado a los alumnos después de la actividad. Los resultados obtenidos coinciden con las impresiones percibidas intuitivamente en la clase y muestran posibles orientaciones para futuros círculos de lectura en las clases de Literatura Inglesa en los cursos de Lengua.