Miracle-dz/UniFAR-FTUs huggingface dataset:
Cell Sheet Engineering for Periodontal Regeneration

two weeks using a mito‐ mycin C-treated 3T3 feeder layer and transplanted directly into the denuded corneal surfa‐ ces without sutures. The results demonstrated that complete re-epithelialization of the corneal surfaces occurred, and the vision of all patients was restored. Recently, autologous oral mucosal epithelial cell sheets cultured with UpCell-Insert technology (CellSeed, Tokyo, Japan) without the feeder layer were transplanted into 25 patients for the treatment of cor‐ neal limbal epithelial deficiency in France The safety of the products was established during the 360-day follow-up, and the results confirmed its efficacy for reconstructing the ocular surface. (Burillon et al., 2012). dentin in more than 60% of the samples. Collagen fibers were inserted perpendicularly into the newly formed cementum-like tissue, and this orientation resembled the native Sharpey’s fibers. In addition, the regenerative potential of hPDL cell sheets cultured with the osteoinductive medium the was confirmed, when hPDL cell sheets were transplanted onto the root surface of periodontal defects in athymic rat mandibles (Flores et al., 2008b). The results indicate that most of the specimens in the experimental group exhibited a newly-formed cementum and a new attachment of collagen fibers to the cementum layer. No clear cementum layer was observed in the control group (in the absence of osteoinductive supplements). As shown in these experiments, hPDL cells cultured with osteoinductive medium could contribute to the simultaneous regeneration of cementum and PDL. manner, and bone defects were filled with porous beta-tricalcium phosphate (β-TCP). Cell sheet transplantation regenerated both new bone and cementum connecting with the well-oriented collagen fibers, while only limited bone regen‐ eration was observed in the control group where cell sheet transplantation was not per‐ formed. These results suggest that PDL cells have multiple differentiation properties that allow for the regeneration of periodontal tissues composed of hard and soft tissues. Next, we evaluated the safety and efficacy of PDL cell sheets in a one-wall infrabony defect model (Tsumanuma et al., 2011), which is considered to be a severe defect model (Kim et al., 2004). In this study, we also compared the differences in the periodontal healing of various cell sources. PDL cells, bone marrow derived mesenchymal stem cells, and alveolar perios‐ teal cells were obtained from each animal, three-layered canine cell sheets were transplanted in an autologous manner, and bone defects were filled with porous β-TCP with 3% type I collagen gelto stabilize the graft shape. Eight weeks after transplantation, significantly more periodontal regeneration was observed in the newly formed cementum and well-oriented PDL fibers more in the PDL cell sheets group than in the other groups. These results indicate that PDL cell sheets combined with β-TCP/collagen scaffold serve as a promising tool for pe‐ riodontal regeneration.
A quasi-Monte Carlo comparison of developments in parametric and semi-parametric regression methods for heavy-tailed and non-normal data

Article: Jones, Andrew Michael orcid.org/0000-0003-4114-1785, Lomas, James, Moore, Peter et al. (1 more author) (2015) A quasi-Monte Carlo comparison of developments in parametric and semi-parametric regression methods for heavy-tailed and non-normal data : with an application to healthcare costs. Journal of the Royal Statistical Society: Series A (Statistics in Society). pp. 951-974. ISSN 1467-985X
AN APPROACH TO THE CONTEMPORARY TREATMENT OF VERTICAL INTEGRATION CASES IN ANTITRUST LAW FROM A LAW & ECONOMICS PERSPECTIVE: RECENT EXPERIENCES IN THE U.S. AND E.U.

After more than one-hundred years of experimenting and accumulating experience, antitrust lawyers are only comfortable making a few statements. Luckily, the significance of economic analysis in antitrust law application is blessed in one of those comfort zones. Although the extent to which economic analysis should impact antitrust law application is still a matter of debate, there is no doubt that “all antitrust law cases must make economic sense”. Yet, the gap between the legal interpretation of antitrust rules applicable to vertical relationships (vertical mergers and vertical restraints, together) and the correct approach suggested by their economic analysis still seems quite substantial. Perhaps, among all areas in antitrust, this gap reaches its greatest dimensions when dealing with issues concerning the treatment of vertical integration matters. Therefore, vertical integration matters are among the most delicate fields of antitrust law policy. This was precisely the reason why a flood of learned commentary (Allen, 1971; McGee and Bassett, 1976; Bork, 1978; Williamson, 1979; Posner, 1976/2001; Armentano, 1982) that focused on the mishandling of the economics of vertical integration followed the initial controversial decisions regarding vertical merger matters despite vertical merger issues commanding less attention from the U.S. Supreme Court than many other issues arising in merger cases.
Extending the Search for Muon Neutrinos Coincident with Gamma-Ray Bursts in IceCube Data

We present an all-sky search for muon neutrinos produced during the prompt γ-ray emission of 1172 gamma-ray bursts (GRBs) with the IceCube Neutrino Observatory. The detection of these neutrinos would constitute evidence for ultra-high-energy cosmic-ray (UHECR) production in GRBs, as interactions between accelerated protons and the prompt γ-ray field would yield charged pions, which decay to neutrinos. A previously reported search for muon neutrino tracks from northern hemisphere GRBs has been extended to include three additional years of IceCube data. A search for such tracks from southern hemisphere GRBs in five years of IceCube data has been introduced to enhance our sensitivity to the highest energy neutrinos. No significant correlation between neutrino events and observed GRBs is seen in the new data. Combining this result with previous muon neutrino track searches and a search for cascade signature events from all neutrino flavors, we obtain new constraints for single-zone fireball models of GRB neutrino and UHECR production.
WAVELET -BASED WARPING TECHNIQUE FOR MOBILE DEVICES

The role of digital images is increasing rapidly in mobile devices. They are used in many applications including virtual tours, virtual reality, e-commerce etc. Such applications synthesize realistic looking novel views of the reference images on mobile devices using the techniques like image-based rendering (IBR). However, with this increasing role of digital images comes the serious issue of processing large images which requires considerable time. Hence, methods to compress these large images are very important. Wavelets are excellent data compression tools that can be used with IBR algorithms to generate the novel views of compressed image data. This paper proposes a framework that uses wavelet-based warping technique to render novel views of compressed images on mobile/ handheld devices. The experiments are performed using Android Development Tools (ADT) which shows the proposed framework gives better results for large images in terms of rendering time.
The MADP Toolbox An Open Source Library for Planning and Learning in (Multi-)Agent Systems

This article describes the Multiagent Decision Process ( MADP ) Toolbox, a software library to support planning and learning for intelligent agents and multiagent systems in uncertain environments. Key features are that it supports partially observable environments and stochastic transition models; has uniﬁed support for single- and multiagent systems; provides a large number of models for decision-theoretic decision making, including one-shot and sequential decision making under various assumptions of observability and cooperation, such as Dec-POMDPs and POSGs; provides tools and parsers to quickly prototype new problems; provides an extensive range of planning and learning algorithms for single- and multiagent systems; is released under the GNU GPL v3 license; and is written in C++ and designed to be extensible via the object-oriented paradigm.
Financial Determinants of Foreign Direct Investment

We argue that mainstream FDI theory underplays financial motivations for interna-tional investment, and suggest several possible channels for a distinct cost-of-capital effect on FDI. Using a sample of European firms’ cross-border acquisitions, and controlling for traditional firm-level determinants of FDI, we find strong evidence in favor of a cost-of-equity effect, whereas the effect of debt costs is indeterminate. We further find that financial determinants are more important for firms originating in relatively less financially developed countries and for firms with high knowledge intensity.
0 . 3 PIN-0 . 4 Pb ( Mg 1 / 3 Nb 2 / 3 ) O 3-0 . 3 PbTiO 3 fl ake array

Harvesting energy from human motion to power wearable devices using flexible piezoelectric energy harvesters is becoming a hot research topic, since this approach could fix the charging problem related to batteries and would do no harm to the environment. Unlike nano-generators, which have a piezoelectric material thickness at the level of a few nm to a few μm, we present a high-performance macro-flexible piezoelectric energy harvester (MF-PEH) with a piezoelectric material thickness of 45 μm, based on a 0.3PIN-0.4PMN-0.3PT (PIMNT) long flake array with an optimized cut. The piezoelectric properties of (110)-oriented PIMNT were studied as a function of thickness and compared to those of 0.7Pb(Mg1/3Nb2/3)O3-0.3PbTiO3 (PMNT). The electrical properties of this device under different strain and load resistances are studied systematically. The results of our experiment show that under a strain of 0.225%, the opencircuit voltage and short-circuit current of MF-PEH reach levels as high as 23.2 V and 0.105 mA (at an excitation frequency of 1.1 Hz), respectively, with a maximum electric output power of 245 μW across a piezoelectric materials area of 400 mm. We have also used the device to harvest mechanical energy from the motion of human knees and charge a battery successfully. Efficient conversion from mechanical energy to electric energy and large output power demonstrate that our MF-PEH is an important complement to flexible energy harvesters and a potential candidate as a self-powered source for wearable low-power electronics.
CARBON DIOXIDE (CO2) STORAGE AND SEQUESTRATION IN THE LEYTE GEOTHERMAL RESERVATION, PHILIPPINES

The study estimated the existing stored carbon (C) and rate of sequestration by vegetation that can potentially serve as sink for the carbon dioxide emitted from eight geothermal plants in Leyte Geothermal Reservation, Philippines. For the 20,438 ha watershed in the vicinity of the power project, the total C storage is 3.84 Mt C (14.10 Mt CO2) while C sequestration based on biomass change was 47.35 Kt C (173.77 Kt CO2). Relative to power plant emission, the C stored in the reserve is equivalent to more than 22 years of CO2 emission. Annual C sequestration is 27% of CO2 emission per year. For the next 25 years, two scenarios were projected. Under Scenario I ("Business as usual"), the forest reserve will be able to store and sequester more than 32 years of CO2 emission from the power plants. Under Scenario II (Accelerated Reforestation), the reserve can store and sequester about 34 years of CO2 emission
Kontakt-Erziehung, alte und neue Medien: Reflexionen über eine Friedensinitiative in Norwegen Contact education, old and new media: Reflections on a peace-building initiative in Norway Wilhelm Kempf Die Wirkung politischer Nachrichten auf die Einschätzung des israelisch- palästinensischen Konflik

In 2001, a peace foundation was set up in Southern Norway, where a regional WW II Gestapo headquarters became a non-profit venue with a vision of becoming a nationally recognized peace education center. The first two years saw regular threats of bankruptcy and little recognition. Then, the vision took hold Archbishop Desmond Tutu of South Africa came to visit twice, and a joint venture agreement was signed with the UNESCO-listed Robben Island Heritage Museum in Cape Town. Several other alliances were forged. But what was it about this vision that suddenly caught the attention of individuals and organizations engaged in peace work? Can we learn something from the history of the center about peace education as a kind of narrative strategy?  2008 by verlag irena regener berlin 1 Oddgeir Tveiten conflict & communication online, Vol. 7, No. 2, 2008 Contact education, old and new media: Reflections on a peace-building initiative in Norway
PRE-PRINT A robot that walked 65 km on a single charge: energy-effective and reliable locomotion using trajectory optimization and stabilization from reflexes∗

No legged walking robot yet approaches the high reliability and the low power usage of a walking person, even on flat ground. Here we describe a robot which makes small progress towards that goal. Ranger is a knee-less 4-legged ‘bipedal’ robot which is energetically and computationally autonomous, except for radio controled steering. It has a total cost of transport [TCOT ≡ P/mgv] of 0.19, less than a human’s TCOT ≈ 0.3. Ranger walked 65.2 km in 186,076 steps in about 31 hours without being touched by a human (using a not yet fully optimized controller with a TCOT of 0.28). The high reliability and low energy use are achieved by: 1) development of an accurate bench-test-based simulation; 2) numerical trajectory optimization using that simulation; 3) a simplified trajectory optimization to ease implementation; and 4) offline design of a simple event-driven discrete feed-forward stabilizing controller. At TCOT = 0.19, the robot’s total power of 11.5 W is used by sensors, processors and communications (45%), motor dissipation (≈34%) and positive mechanical work (≈21%). Ranger’s reliability and low energy use suggests that simplified implementation of offline trajectory optimization, stabilized by a low-bandwidth reflex-based controller, might lead to energy-effective reliable walking of more complex robots. ∗Other candidate titles: The first robot to walk a marathon A robot that can walk far using little energy Energy-effective, reliable 2D walking via trajectory optimization and reflex based control An energy-effective and reliable walking robot via trajectory optimization and reflex based control A robot that can walk far using little energy using trajectory optimization and event-based stabilization Funding from NSF grant 52836 to AR.
Perturbative corrections to the Gutzwiller mean-field solution of the Mott-Hubbard model

We study the Mott-insulator transition of bosonic atoms in optical lattices. Using perturbation theory, we analyze the deviations from the mean-field Gutzwiller ansatz, which become appreciable for intermediate values of the ratio between hopping amplitude and interaction energy. We discuss corrections to number fluctuations, order parameter, and compressibility. In particular, we improve the description of the short-range correlations in the one-particle density matrix. These corrections are important for experimentally observed expansion patterns, both for bulk lattices and in a confining trap potential.
Adolescent Bullying and Sleep Difficulties

This study evaluated whether adolescents who report having been bullied, being bullies, or report both being a bully and being bullied experience more sleep difficulties than children uninvolved in bullying. The study drew upon cognitive theories of insomnia, investigating whether the extent to which young people report worrying about bullying can moderate associations between victimization and sleep difficulties. Participants were 5420 adolescents who completed a self-report questionnaire. Pure Victims (OR = 1.72, 95% CI [1.07, 2.75]), Pure Bullies (OR = 1.80, 95% CI [1.16, 2.81]), and Bully-Victims (OR = 2.90, 95% CI [1.17, 4.92]) were all more likely to experience sleep difficulties when compared to uninvolved young people. The extent to which young people reported worrying about being bullied did not moderate the links between victimization and sleep difficulties. In this way, bullying is clearly related to sleep difficulties among adolescents but the conceptual reach of the cognitive model of insomnia in this domain is questioned.
STUDY THE AMINO ACID BEHAVIOUR IN CHITOSAN CONTAINING SPRAY DRIED POWDER FOR PULMONARY DRUG DELIVERY

For a dry powder carrier platform to be suitable for pulmonary delivery of potent biomacromolecules, it has to be aerosolisable and capable of reach to the deep part of the lung such as alveoli. In the present study, strategies aiming to produce a multi-component spray-dried powder formulation with a stable amorphous glassy matrix containing mannitol as a deaggregating agent, while using different amino acid such as acids arginine, leucine, phenylalanine and threonine as a particle formation and aerosolisation enhancing agent were investigated. Parameters such as spray-dried yield, tapped density, and Carr's Index were performed. In addition, whilst the majority of amino acid-modified powders displayed suitable particle size distribution for pulmonary administration and potentially favourable high fine particle fractions (FPF) and formulations in vitro particle deposition was only enhanced for the leucine-modified powder. Scanning electronic micrographs (SEM) revealed distinct morphological features of these. In conclusion, the results suggest that with suitable particle size, good dispersibility leucine can be used to enhance the dispersibility and aerosolisation properties of spray-dried powders for pulmonary drug delivery. And appear to have good potential for development into a universal carrier platform for pulmonary delivery.
Effects of Lycium barbarum Polysaccharides on the Apoptosis of Human Hepatoma SMMC-7721 Cells

Lycium barbarum polysaccharide is a natural functional component which has a variety of biological activities. The composition and apoptosis inducing activities on human hepatoma SMMC-7721 cells of Lycium barbarum Polysaccharide fraction (LBP1) was investigated. The results showed that LBP1 consisted of neutral sugars, uronic acid and protein. LBP1 was composed of three kinds of monosaccharides including mannose, galactose and glucose. The molecule weight of LBP1 was 367 KDa. SMMC-7721 cells were cultured in the presence of LBP1 at various concentrations (50-400 mg/L) for 2 days, 4 days and 6 days and the percentage of cell viability was evaluated by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay. We found that anti-proliferative effect of LBP1 was associated with apoptosis on SMMC-7721 cells by morphological changes and cell cycle arresting at G0/G1phase. Furthermore, LBP1 could induce cell apoptosis which was closely accompanied with the enhancement of Reactive Oxygen Species (ROS) level, dissipation of Mitochondria Membrane Potential (MMP), increase expression of Bax mRNA and decrease expression of Bcl-2 mRNA. These results suggested that SMMC-7721 cell apoptosis induced by LBP1 mainly was mediated by mitochondrial pathways. However, further research on the molecular mechanisms of LBP1 effecting on the cells’ mitochondria is necessary.
RELATING TEACHING QUALIFICATIONS

Introduction: Teaching Qualifications (TQs) have been implemented in University Medical Centers, but their relation to teachers’ motivation for medical teaching is unknown. Because teacher motivation influences important outcomes, it is crucial to study how TQs are related to promoting teacher motivation, by fulfilling the basic needs of feeling autonomous, competent, and related towards medical teaching. Aims: To explore relations between TQs and feelings of autonomy, competence, and relatedness towards medical teaching. Methods: An online questionnaire was used to collect data about teaching at a university hospital. We measured feelings of autonomy, competence, and relatedness towards medical teaching using the Teaching-related Basic Need Satisfaction scale (TBNS). We applied multivariate regression analysis to examine relations between TQs and basic need satisfaction in teaching. * Corresponding Author: Rik.engbers@radboudumc.nl. Rik Engbers, Cornelia R. M. G. Fluit, Sanneke Bolhuis et al. 2 Results: A total of 767 medical teachers participated. TQs appear to be related to feeling competent in teaching. Higher TQ levels are not related to higher feelings of autonomy, competence, and relatedness towards medical teaching. Conclusion: The results imply that appealing to non-qualified teachers’ feelings of competence towards medical teaching may stir up their enthusiasm for TQ policy. They also call for robust teaching positions to build teaching experience, preferably as early as possible, and for assessing the importance applicants attach to education in job interviews.
Computational Visual Attention Models

The human visual system (HVS) has evolved to have the ability to selectively focus on the most relevant parts of a visual scene. This mechanism, referred to as visual attention (VA), has been the focus of several neurological and psychological studies in the past few decades. These studies have inspired several computational VA models which have been successfully applied to problems in computer vision and robotics. In this paper we provide a comprehensive survey of the state-of-the-art in computational VA modeling with a special focus on the latest trends. We review several models published since 2012. We also discuss theoretical advantages and disadvantages of each approach. In addition, we describe existing methodologies to evaluate computational models through the use of eye-tracking data along with the VA performance metrics used. We also discuss shortcomings in existing approaches and describe approaches to overcome these shortcomings. A recent subjective evaluation for benchmarking existing VA metrics is also presented and open problems in VA are discussed. M. S. Gide and L. J. Karam Computational Visual Attention Models. Foundations and Trends © in Signal Processing, vol. 10, no. 4, pp. 347–427, 2016. DOI: 10.1561/2000000055.
Wilkhu, Jitinder S. and Ouyang, Defang and Kirchmeier, Marc J. and Anderson, David E and Perrie, Yvonne (2014) Investigating the role of cholesterol in the formation of non-ionic surfactant based bilayer

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