Miracle-dz/UniFAR-FTUs huggingface dataset:
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Catalytic receptors

The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands ( www.guidetopharmacology.org ), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley. com/doi/10.1111/bph.14751 . Catalytic receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, ion channels, nuclear hormone receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2019, and supersedes data presented in the 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
An Evaluation of Factors Influencing Intentions to Major in Information Systems

: The field of information systems (IS) is facing a dilemma-a decline in the num ber of students majoring in IS at a time when demand for IS graduates is increasing. There is therefore a need to determine ways to encourage freshmen and sophomores to consider IS as a potential major. The current research project utilized the Theory of Reasoned Action (TRA) to determine what factors influence undergraduate business students to consider a major in IS. The results from a sample of 169 undergraduates on a number of variables are reported. TRA was found to be valid in this context, and several useful recommendations are made in terms of what can be done to encourage students to select a major in IS at the undergraduate level.
Hotspot Mitigations for the Masses

In an IaaS cloud, the dynamic VM scheduler observes and mitigates resource hotspots to maintain performance in an oversubscribed environment. Most systems are focused on schedulers that fit very large infrastructures, which lead to workload-dependent optimisations, thereby limiting their portability. However, while the number of massive public clouds is very small, there is a countless number of private clouds running very different workloads. In that context, we consider that it is essential to look for schedulers that overcome the workload diversity observed in private clouds to benefit as many use cases as possible. The Acropolis Dynamic Scheduler (ADS) mitigates hotspots in private clouds managed by the Acropolis Operating System. In this paper, we review the design and implementation of ADS and the major changes we made since 2017 to improve its portability. We rely on thousands of customer cluster traces to illustrate the motivation behind the changes, revisit existing approaches, propose alternatives when needed and qualify their respective benefits. Finally, we discuss the lessons learned from an engineering point of view.
Acute low- compared to high-load resistance training to failure results in greater energy expenditure during exercise in healthy young men

The objective of the present study was to verify the energy expenditure (EE), energy system contributions and autonomic control during and after an acute low-load or high-load resistance training (RT) protocol to momentary failure (MF) in young adults. Eleven young men (22 ± 3 yrs, 71.8 ± 7.7 kg; 1.75 ± 0.06 m) underwent a randomized crossover design of three knee extension acute protocols: a low-load RT [30% of their maximal strength (1RM); RT30] or a high-load RT (80% of 1RM; RT80) protocol, with all sets being performed to MF; or a control session (Control) without exercise. Participants were measured for EE, energy system contributions, and cardiac autonomic control before, during, and after each exercise session. Exercise EE was significantly higher for RT30 as compared to RT80. Furthermore, post measurements of blood lactate levels and the anaerobic lactic system contribution were significantly greater for RT30 as compared to RT80. In addition, parasympathetic restoration was lower for RT30 as compared to RT80. In conclusion, a low-load (30% 1RM) RT session produced higher EE during exercise than a high-load (80% 1RM) RT session to MF, and may be a good option for fitness professionals, exercise physiologists, and practitioners when choosing the optimal RT protocol that provides more EE, especially for those who want or need to lose weight.
Stereotactic Radiotherapy with Fractionation for the Lesions in and Around the Brainstem and Optic Nerve

Purpose Among the components of the central nervous system, the optic nerve and the brainstem are considered to be the eloquent structures that are sensitive to stereotactic radiosurgery (SRS) and stereotactic radiotherapy (SRT). SRS or SRT with fractionation in areas adjacent to these tissues is both promising and challenging. Materials and methods To clarify the precise dose distribution achievable with fractionation in and around the optic nerve and brainstem, theoretical simulations were performed, based on the biological effective dose (BED). Results These simulations clearly showed that the doses to the optic nerve and brainstem can be adjusted using fractionation, meaning that the prescribed doses to the surrounding brain tissue can be reduced. Conversely doses to the lesions themselves can be increased by fractionation, while maintaining a stable dose to normal optic nerve and brainstem tissue.
Simultaneous revascularization of the occluded internal carotid artery using the Solitaire as a workhorse wire during acute ischemic stroke intervention

Introduction Tandem lesions involving a large vessel occlusion intracranially with concomitant cervical carotid critical stenosis or occlusion are a common presentation of acute ischemic stroke. These lesions are both challenging and time-consuming but can be extremely beneficial for patients when successful. We present a technique utilizing the pusher wire of the stent retriever used for intracranial thrombectomy as the workhorse wire for carotid intervention using a monorail system to perform cervical carotid angioplasty. Methods We reviewed four successive patients who presented with a tandem occlusion and underwent thrombectomy and simultaneous carotid artery intervention using this technique. Results All four patients had radiographically successful intracranial thrombectomy and cervical carotid revascularization. Time from groin puncture to intracranial stent retriever deployment was 63 min on average. Then, using the pusher wire as a monorail workhorse, time from stent retriever deployment to carotid angioplasty was on average 6 min. Discussion This technique allows for cervical carotid revascularization to begin during the recommended 5-min wait time after stent retriever deployment, allowing for rapid near-simultaneous revascularization across both lesions. This technique has been reported briefly in the past for management of a cervical dissection. There is continued debate regarding the management of tandem occlusions, as to which lesion should be managed first. Conclusion As the management paradigms of tandem occlusions continue to evolve, this technique may improve outcomes by expediting endovascular intervention. Using the stent retriever wire provides a method of expediting the management of the proximal lesion after addressing the more distal intracranial occlusion first.
Molecular Detection and Subtyping of Blastocystis in Korean Pigs

Blastocystis is one of the most commonly detected genera of protozoan parasites in the human intestines as well as the intestines of many other species such as pigs in several geographical regions worldwide. However, no studies have examined Blastocystis in pigs in Korea. In this study, PCR and nucleotide sequencing were performed to evaluate the genetic diversity and zoonotic potential of Blastocystis using pig fecal samples. We obtained 646 stool samples from groups of piglets, weaners, growers, finishers, and sows in Korea. A total of 390 Blastocystis-positive samples were identified, and the infection rate was 60.4%. The infection rates were significantly related to age and region. The 4 subtypes (STs) of Blastocystis confirmed by phylogenetic analysis were ST1, ST2, ST3, and ST5, indicating the high genetic diversity of Blastocystis in Korean pigs. ST5 was highly distributed in Korean pigs among detected STs in this study. Some sequences were closely related to those of Blastocystis isolated from humans. This is the first study of Blastocystis in pigs in Korea. Based on the results, Blastocystis is prevalent in Korean pigs. Although a small number of samples were obtained in some areas, the clinical development of Blastocystis infection in pigs and potential for human transmission should be further examined.
Self-care practices and psychosocial distress for people with type 2 diabetes mellitus in Dar es salaam, tanzania.

Nutritional intake and modification of lifestyle are the cornerstones for management of Type 2 diabetes. It has been recognized that, in order to achieve satisfactory metabolic control, adoption of self-care skills by the diabetic person is crucial. The aim of this study was to determine self-care practices and diabetes related emotional distress for people with Type 2 diabetes mellitus in Dar es Salaam, Tanzania. A cross sectional survey involving 121 people with Types 2 diabetes was conducted in four diabetic clinics located in Dar es Salaam. Both descriptive and inferential statistical analyses were carried out using Statistical Package for Social Sciences (SPSS 11.5). Result of the study showed that, the level of self-care practices in area of diet, physical exercises, medication, and blood glucose test was not up to desired level of practice requiring following of all of the recommendations in seven days per week without missing. Diabetic related emotion distress for studied sample was low and comparable to levels reported in other studies however the level was not in line with the score recommended in PAID. The recommended PAID score for emotion is zero. For this reason, efforts are needed to reduce the emotional stress among diabetic subjects. The main problem in self-care was financial limitation and lack of care education. Efforts are therefore required to improve the quality of care including self-care education, counselling and medical support. Following the result of this study it is recommended that, the government and other stakeholders should increase effort to lower the cost of diabetic services like diabetic tests and medications; Given the importance of self monitoring of blood glucose to diabetes care, government, and other stakeholders should strive to make the procedure readily accessible and affordable for all patients who require; Further research is needed to determine optimum self-care practices and diabetic related emotional distress levels that can predict good glycemic control that would help researcher and programme managers to be able to monitor the progress of diabetic care programs. ii
Proceedings of the 12th European Lisp Symposium (ELS 2019), Genova, Italy, April 1-2, 2019

sexp-rewrite is an Emacs library for doing pattern-based rewriting of S-expression-structured code—ie, code in Lisp, Scheme, and Racket. The library provides a simple but powerful pattern language that enables users to define rewriting rules (called “tactics”) and auxiliary nonterminals. CCS CONCEPTS • Software and its engineering → Domain specific languages; Development frameworks and environments; ACM Reference Format: Ryan Culpepper. 2019. Pattern-Based S-Expression Rewriting in Emacs. In Proceedings of the 12th European Lisp Symposium (ELS’19). ACM, New York, NY, USA, 3 pages. https://doi.org/10.5281/zenodo.2642093
Rumination and perceived social support from significant others interact to predict eating disorder attitudes and behaviors in university students

Abstract Objective University students are at a greater risk for eating disorder attitudes and behaviors (EDAB) compared to the general population. This study examined the roles of rumination and perceived social support (PSS) from three domains in the occurrence of EDAB. Participants: A sample of students (N= 300) attending a rural Midwestern university. Methods: Participants completed online surveys which collected demographic information and assessed eating disorders, rumination, and PSS. Pearson’s correlation and moderated regression were performed for analysis. Results: Of the sample, 63.6% of participants identified as women, 34.8% as men, and 1.7% with another gender. PSS from family and friends was negatively associated with EDAB. Rumination was positively associated with EDAB. High rumination and high PSS from significant others interacted to predict eating, shape, and weight concerns, but not dietary restraint. Conclusions: Findings support incorporating screening tools for PSS and rumination at on-campus counseling sessions to identify students at risk for EDAB.
Two SNP Mutations Turned off Seed Shattering in Rice

Seed shattering is an important agronomic trait in rice domestication. In this study, using a near-isogenic line (NIL-hs1) from Oryza barthii, we found a hybrid seed shattering phenomenon between the NIL-hs1 and its recurrent parent, a japonica variety Yundao 1. The heterozygotes at hybrid shattering 1 (HS1) exhibited the shattering phenotype, whereas the homozygotes from both parents conferred the non-shattering. The causal HS1 gene for hybrid shattering was located in the region between SSR marker RM17604 and RM8220 on chromosome 4. Sequence verification indicated that HS1 was identical to SH4, and HS1 controlled the hybrid shattering due to harboring the ancestral haplotype, the G allele at G237T site and C allele at C760T site from each parent. Comparative analysis at SH4 showed that all the accessions containing ancestral haplotype, including 78 wild relatives of rice and 8 African cultivated rice, had the shattering phenotype, whereas all the accessions with either of the homozygous domestic haplotypes at one of the two sites, including 17 wild relatives of rice, 111 African cultivated rice and 65 Asian cultivated rice, showed the non-shattering phenotype. Dominant complementation of the G allele at G237T site and the C allele at C760T site in HS1 led to a hybrid shattering phenotype. These results help to shed light on the nature of seed shattering in rice during domestication and improve the moderate shattering varieties adapted to mechanized harvest.
Exploring Spatial and Mobility Pattern’s Effects for Collaborative Point-of-Interest Recommendation

In recent years, researches on the mining of user check-in behaviors for point-of-interest(POI) recommendations has attracted a lot of attention. Personalized POI recommendation is a significant task in location-based social networks(LBSNs) because it helps target users explore their surrounding environment and greatly benefits the business in real life. Although a personalized POI recommendation system can significantly facilitate users’ outdoor activities, it faces many challenging problems, such as the hardness to model human mobility and the difficulty to address data sparsity. Moreover, geographical influence on users should be personalized, but current studies only model the geographical influence on all users’ check-in behaviors in a universal way. In this paper, we design a novel and effective personalized POI recommendation system. First, our system mines the target user’s active area based on his or her check-in history, and designs a personalized user spatial similarity calculation method based on the target user’s active area. Secondly, our system takes into account three features of the human mobility pattern: spatial, temporal, and sequential properties. Furthermore, our system designs a novel personalized user mobility pattern similarity calculation method based on the features of human mobility pattern. Finally, a recommendation list is generated based on the idea of collaborative filtering. Compared with the state-of-the-art POI recommendation approaches, the experimental results demonstrate that our system achieves much better performance.
KBGen – Text Generation from Knowledge Bases as a New Shared Task

In this paper we propose a new shared task, KBGen, where the aim is to produce coherent descriptions of concepts and relationships in a frame-based knowledge base (KB). We propose to use the AURA knowledge base for the shared task which contains information about biological entities and processes. We describe how the AURA KB provides an application context for NLG and illustrate how this application context generalizes to other biology KBs. We argue that the easy availability of input data and a research community -- both domain experts and knowledge representation experts -- which actively uses these knowledge bases, along with regular evaluation experiments, creates an ideal scenario for a shared task.
Usual Dietary Intake and Adherence to Dietary Recommendations among Southwest American-Indian Youths at Risk of Type 2 Diabetes

ABSTRACT Background American Indians are disproportionately affected by obesity and diabetes, and American-Indian youths have the highest prevalence of obesity and diabetes among all ethnic groups in the USA. Objectives The purposes of this study were to assess the usual dietary intake in American-Indian youths who attended a wellness camp program; adherence to the Dietary Guidelines for Americans 2015–2020 (DGA) and to the Healthy People 2020 Objectives; and to compare pre- and postcamp reported diets. Methods A total of six 24-h dietary recalls were conducted in person with American-Indian youths (aged 10–15 y; n = 26) from 3 different Southwest tribes. Three recalls were conducted before the wellness camp, and 3 were conducted after the camp. A series of 2-factor ANOVA were conducted, using a mixed model, to compare the nutrition differences before and after the health camp using a statistical program, R. Results Adherence to federal dietary recommendations was low, with few of the youths meeting the DGA recommendations for fruits (15%, average serving 0.69 cup/d) and vegetables (35%, average serving 0.59 cup/d). All of the participants exceeded the DGA recommended limit on empty calories. Nutrient analysis of total fat intake showed a significant decrease in intake after the camp, F (1, 52) = 5.68, P = 0.02. Conclusions Diet is a modifiable risk factor for obesity and chronic diseases such as type 2 diabetes and needs to be an integral part of any healthy lifestyle intervention. The camp-based nutrition education had a positive effect on youths, as observed through the total fat intake decreasing after camp. To reinforce nutrition education, future nutrition education should involve parents, be delivered beyond the week at camp, and encompass social determinants of health and access to healthy foods.
Crystal structures, syntheses, and spectroscopic and electrochemical measurements of two push–pull chromophores: 2-[4-(dimethylamino)benzylidene]-1H-indene-1,3(2H)-dione and (E)-2-{3-[4-(dimethylamino)phenyl]allylidene}-1H-indene-1,3(2H)-dione

The title pull–push chromophores, 2-[4-(dimethylamino)benzylidene]-1H-indene-1,3(2H)-dione (ID[1]) and (E)-2-{3-[4-(dimethylamino)phenyl]allylidene}-1H-indene-1,3(2H)-dione (ID[2]), with donor–π-bridge–acceptor structures, are almost planar for the molecule with a short π-bridge (ID[1]) but less planar for the molecule with a longer bridge (ID[2]).
Integrated proteogenetic analysis reveals the landscape of a mitochondrial-autophagosome synapse during PARK2-dependent mitophagy

We explore the landscape of a mitochondrial-autophagosome synapse during mitophagy using proteomics and genetic screens. The PINK1 protein kinase activates the PARK2 ubiquitin ligase to promote mitochondrial ubiquitylation and recruitment of ubiquitin-binding mitophagy receptors typified by OPTN and TAX1BP1. Here, we combine proximity biotinylation of OPTN and TAX1BP1 with CRISPR-Cas9–based screens for mitophagic flux to develop a spatial proteogenetic map of PARK2-dependent mitophagy. Proximity labeling of OPTN allowed visualization of a “mitochondrial-autophagosome synapse” upon mitochondrial depolarization. Proximity proteomics of OPTN and TAX1BP1 revealed numerous proteins at the synapse, including both PARK2 substrates and autophagy components. Parallel mitophagic flux screens identified proteins with roles in autophagy, vesicle formation and fusion, as well as PARK2 targets, many of which were also identified via proximity proteomics. One protein identified in both approaches, HK2, promotes assembly of a high–molecular weight complex of PINK1 and phosphorylation of ubiquitin in response to mitochondrial damage. This work provides a resource for understanding the spatial and molecular landscape of PARK2-dependent mitophagy.
Answer set programming as a modelinglanguage for course timetabling

The course timetabling problem can be generally defined as the task of assigning a number of lectures to a limited set of timeslots and rooms, subject to a given set of hard and soft constraints. The modeling language for course timetabling is required to be expressive enough to specify a wide variety of soft constraints and objective functions. Furthermore, the resulting encoding is required to be extensible for capturing new constraints and for switching them between hard and soft, and to be flexible enough to deal with different formulations. In this paper, we propose to make effective use of ASP as a modeling language for course timetabling. We show that our ASP-based approach can naturally satisfy the above requirements, through an ASP encoding of the curriculum-based course timetabling problem proposed in the third track of the second international timetabling competition (ITC-2007). Our encoding is compact and human-readable, since each constraint is individually expressed by either one or two rules. Each hard constraint is expressed by using integrity constraints and aggregates of ASP. Each soft constraint S is expressed by rules in which the head is the form of penalty(S,V,C), and a violation V and its penalty cost C are detected and calculated respectively in the body. We carried out experiments on four different benchmark sets with five different formulations. We succeeded either in improving the bounds or producing the same bounds for many combinations of problem instances and formulations, compared with the previous best known bounds.