Miracle-dz/UniFAR-FTUs huggingface dataset:
Calcitriol in Human T Cells Cutting Edge: AhR Is a Molecular Target of

The immunoregulatory functions of vitamin D have been well documented in various immunological disorders, including multiple sclerosis, arthritis, and asthma. IL-10 is considered a chief effector molecule that promotes the vitamin D–induced immunosuppressive states of T cells and accessory cells. In this article, we demonstrate that the active form of vitamin D, 1,25-dihydroxy-vitamin D 3 (calcitriol), has a profound inhibitory effect on the development of human Th9, a CD4 T cell subset that is highly associated with asthma, in an IL-10–inde-pendent manner. Our data show that calcitriol represses the expression of BATF, a transcription factor essential for Th9, via suppressing the expression of aryl hydrocarbon receptor, without an increase in IL-10. The data show a novel link between vitamin D and two key transcription factors involved in T cell differentiation. The Journal of Immunology , 2015, 195: 000–000. its inﬂuence D receptor . in cir-culating mononuclear cells, and thymus and peripheral and Calcitriol maturation of and their to T lymphocytes modula-tion Other are by calcitriol in
Bound by the Antibody Dendritic Cells Is Dependent on the Epitope Reactivation of Neutralized HIV-1 by

Ab-neutralized HIV-1 can be captured by dendritic cells (DCs), which subsequently transfer infectious HIV-1 to susceptible CD4 + T cells. In this study, we examined the capacity of early Abs, as well as recently identiﬁed broadly neutralizing Abs (bNAbs) targeting different envelope glycoprotein (Env) epitopes, to block HIV-1 transmission by immature and mature DCs to HIV-1– sensitive cells. Three bNAbs directed against the gp41 membrane proximal region of Env (2F5, 4E10, and 10E8) and three gp120 bNAbs targeting the CD4 binding site (b12, VRC01, and NIH45-46) were examined. In addition, eight glycan-dependent bNAbs targeting the V1V2 apex (PG9, PG16, and PGT145), the V3 loop (2G12, PGT121, and PGT128), and the gp120–gp41 interface of Env (PGT151 and 35O22) were tested. bNAbs that bound speciﬁc glycans showed, depending on the immature or mature state of the DC, diverse efﬁciencies in HIV-1 trans -infection. All bNAbs that bound the CD4 binding site blocked trans -infection, whereas all bNAbs directed against the membrane proximal region lost neutralizing activity after DC-mediated HIV-1 transmission. To understand how preneutralized HIV-1 can be transferred as infectious virus by DCs, we followed the processing of 2F5-treated HIV-1 by DCs with confocal microscopy. Inhibition of DC-internalization pathways could not reverse the dissociation of 2F5 from HIV-1, suggesting that Ab dissociation occurs directly at the plasma membrane. Collectively, these ﬁndings
Molecular design through TD-DFT calculation of chiral salen Cu II complexes toward NIR absorption for DSSC

: DSSC (Dye sensitized solar cell) has been researched by many laboratories and dye is main material for the cell. In this study, we designed new six complexes for dye. For effective NIR absorption of cell, these complexes have pi-conjugated and electron withdrawing group. To see the effect of this group on the complexes, we gained the calculated UV-Vis spectra of complexes. As a result, NIR shift by pi-conjugated and electron withdrawing was seen. Experimental UV-Vis spectra of complexes that have electron withdrawing group were also measured. We can expect the DSSC that has effective NIR absorption from this study.
Review on control techniques and methodologies for maximum power extraction from wind energy systems

This review study focuses on various methods and technologies used in past and present for obtaining maximum output power from a wind energy conversion system. There are plenty of solution for maximum power point (MPP), but the problem lies in the effective choice made among them and it needs the expert knowledge on every technique for picking up the best MPP method as every method on its own has some advantages and disadvantages. A comparison has been made among various MPP methods in terms of convergence time, efficiency, training, complexity and wind measurement. Here, different MPP tracking (MPPT) algorithms are classified based on wind speed measurement (WSR) and without WSR models. In this study, from the literature, a novel maximum electrical power tracking (MEPT) and maximum mechanical power tracking (MMPT) methods are compared with state-of-the-art MPPT algorithms. On basis of the results obtained from the literature available, the MEPT algorithm has fast convergence rate of 15 ms; on the other hand, optimal relation-based method is having large convergence rate of 364 ms and less efficient. A case study has been considered for performance validation, and MEPT and MMPT are having a good response for dynamic variation in wind speed.
S0033291720003396jra 1569..1577

Background. Psychosis is associated with a reasoning bias, which manifests as a tendency to ‘jump to conclusions’. We examined this bias in people at clinical high-risk for psychosis (CHR) and investigated its relationship with their clinical outcomes. Methods. In total, 303 CHR subjects and 57 healthy controls (HC) were included. Both groups were assessed at baseline, and after 1 and 2 years. A ‘beads’ task was used to assess reasoning bias. Symptoms and level of functioning were assessed using the Comprehensive Assessment of At-Risk Mental States scale (CAARMS) and the Global Assessment of Functioning (GAF), respectively. During follow up, 58 (16.1%) of the CHR group developed psychosis (CHR-T), and 245 did not (CHR-NT). Logistic regressions, multilevel mixed models, and Cox regression were used to analyse the relationship between reasoning bias and transition to psychosis and level of functioning, at each time point. Results. There was no association between reasoning bias at baseline and the subsequent onset of psychosis. However, when assessed after the transition to psychosis, CHR-T participants showed a greater tendency to jump to conclusions than CHR-NT and HC participants (55, 17, 17%; χ2 = 8.13, p = 0.012). There was a significant association between jumping to conclusions (JTC) at baseline and a reduced level of functioning at 2-year follow-up in the CHR group after adjusting for transition, gender, ethnicity, age, and IQ. Conclusions. In CHR participants, JTC at baseline was associated with adverse functioning at the follow-up. Interventions designed to improve JTC could be beneficial in the CHR population.
The Response to 2-Aminoacrylate Differs in E. coli and S. enterica, Despite Shared Metabolic Components

12 The metabolic network of an organism includes the sum total of the biochemical reactions 13 present. In microbes, this network has an impeccable ability to sense and respond to 14 perturbations caused by internal or external stimuli. The metabolic potential (i.e, network 15 structure) of an organism is often drawn from the genome sequence, based on the presence of 16 enzymes deemed to indicate specific pathways. Escherichia coli and Salmonella enterica are 17 members of the Enterobacteriaceae family of Gram-negative bacteria that share the majority of 18 their metabolic components and regulatory machinery as the “core genome”. In S. enterica, the 19 ability of the enamine intermediate, 2-aminoacrylate (2AA) to inactivate a number of pyridoxal 20 5’-phosphate (PLP)-dependent enzymes has been established in vivo . In this study, 2AA 21 metabolism and the consequences of its accumulation were investigated in E. coli . The data 22 showed that despite the conservation of all relevant enzymes, S. enterica and E. coli differed in 23 both the generation and detrimental consequences of 2AA. In total, the findings suggest that the 24 structure of the metabolic network surrounding the generation and response to endogenous 2AA 25 stress differs between S. enterica and E. coli . 28 The data showed that despite the conservation of all relevant enzymes in the two closely related 30 diverged in their structures. set of aminoacrylate stress response and the differences in metabolic structure and cellular milieu 34 between S. enterica and E. coli . pSU18 PCR Q5 DNA polymerase (New England Biolabs) primers AB3 343 AB4. The product was digested with Hind III (New England Biolabs) and ligated into predigested pAB1. The ligation mixture was transformed into E. coli DH5α and chloramphenicol resistant 345 were selected. Plasmids from the Cm r clones were isolated, the insert confirmed by PCR 346 and the resulting plasmid was pAB2. The P BAD - ilvA219 cat insert from pAB2 was amplified 347 using primers AB5/AB6 or AB5/AB7 and replaced the araBAD genes from E. coli K12 S.
Stellar Feedback and Resolved Stellar IFU Spectroscopy in the nearby Spiral Galaxy NGC Stellar Feedback and Resolved Stellar IFU Spectroscopy in the nearby Spiral

We present MUSE Integral Field Unit (IFU) observations of ﬁve individual HII regions in two giant star-forming complexes in the low-metallicity, nearby dwarf spiral galaxy NGC 300. In combination with high spatial resolution Hubble Space Telescope photometry, we demonstrate the extraction of stellar spectra and classiﬁcation of individual stars from ground-based IFU data at the distance of 2 Mpc. For the two star-forming complexes, in which no O-type stars had previously been identiﬁed, we ﬁnd a total of 13 newly identiﬁed O-type stars, and 4 Wolf-Rayet stars (two already known sources and two Wolf-Rayet star candidates that this work now conﬁrmed). We use the derived massive stellar content to analyze the impact of stellar feedback on the HII regions. As already found for HII regions in the Magellanic Clouds, the dynamics of the analyzed NGC 300 HII regions are dominated by a combination of the pressure of the ionized gas and stellar winds. Moreover, we analyze the relation between the star formation rate and the pressure of the ionized gas as derived from small ( < 100 pc) scales, both quantities being systematically overestimated when derived on galactic scales. With the wealth of upcoming IFU instruments and programs, this study serves as a pathﬁnder for the systematic investigation of resolved stellar feedback in nearby galaxies, delivering the necessary analysis tools to enable massive stellar content and feedback studies sampling an unprecedented range of HII region properties across entire galaxies in the nearby Universe.
Control of Permeationof BleomycinA2by PolyeneAntibioticsin Cultured Chinese HamsterCell&

1 ml of H2Oand mixed thoroughly with 10 ml of Aquasol. Then radioactivities were counted. Protein concentrations were determined by the ABSTRACT Control of permeation of bleomycin A2, a well-known antitu momantibiotic, in combination with various polyene macrolide antibiotics was analyzed in cultured Chinese hamster cells in vitro. Three polyene icin, were found to enhance the action of bleomycin A2remark ably, while amphotenicin B or nystatin could not. Although DNA synthesis and colony-forming activity of polyene-sensitive Chinese hamster V79 cells were synergistically inhibited by the combination of filipin and bleomycin A2, in a polyene-resistant subline (AMBR@1)derived from V79, they were only slightly affected in the presence of both drugs. The cellular uptake of [â€˜4C]bleomycinA2 by V79 was enhanced 2- to 4-fold in the presence of increasing doses of filipin or pentamycin, but not in the presence of amphotenicin B. The treatment of V79 cells with filipin for 20 to 30 mm was enough to block DNA synthesis almost completely when combined with 20 @gbleomycin A2 per ml. The pretreatment of the hamster cells with 6 @gfilipin per ml for 60 mm continued to enhance the inhibitory action by bleomycin A2of DNA synthesis up to 5 hr after the removal of filipin from the cultured medium.
Lessons Learned about Metadata Performance in the PRACE File System Prototype

The purpose of this white paper is to document the measurements obtained in PRACE-2IP regarding file system metadata performance, and to assess mechanisms to further improve such performance. The final goal of the task is to identify the open issues related to file systems for multi-petascale and exascale facilities, and propose novel solutions that can be applied to Lustre, enabling it to manage a huge number of files on a system with many heterogeneous devices while efficiently delivering huge data bandwidth and low latency, minimizing the response time. The performed tasks being reported included the observation, measurement and study of a large scale system currently in production, in order to identify the key metadata-related issues; the development of a prototype aimed to improve the metadata behaviour in such system and also to provide a framework to easily deploy novel metadata management techniques on top of other systems; the measurement and study of specially deployed Lustre and GPFS prototypes to validate the presence of the metadata issues observed in current in-production systems; and finally the porting of the framework prototype to test novel metadata management techniques on both a production system using GPFS and the PRACE Lustre prototype facility at CEA.
Thymusby Conditional Gene Disruption in the E2A An Analysis of T Cell Intrinsic Roles of

The importance of E2A transcription factors in T cell development has been demonstrated in studies of E2A -deﬁcient mice, which display abnormal T cell development and a high frequency of T cell lymphomas. Because E2A expression is not restricted to the T cell lineage, the primary cause of the T cell phenotype in E2A -deﬁcient mice was not fully determined. To further investigate the role of E2A in T cell lineage, we generated mice with the E2A gene disrupted exclusively during thymocyte development using the Cre-lox system. We show that this system allows E2A gene disruption to occur throughout the double-negative stage of thymocyte development. E2A deletion appears to be completed before development reaches the double-positive stage. Consistent with the gene disruption, these mice reveal a T cell intrinsic role for E2A during the transition from the double-negative stage to the double-positive stage of thymocyte development. In contrast to germline E2A knockout mice, conditional E2A knockout mice do not develop T cell lymphoma. This work establishes a new model for further investigating E2A function in T cell development and leukemiogenesis. The Journal of Immunology, 2002, 168: 3923–3932. in the DP and SP stages (Fig. 5 C ). No Cre-mediated deletion was detected in other cell types, including B220 (cid:2) cells, Mac1 (cid:2) cells, and Gr1 (cid:2) cells isolated from bone marrow or spleen (data not shown). These results indicate that the Cre-mediated E2A deletion was initiated after cells have committed to the T cell lineage and was completed before they reach the DP stage of thymopoiesis.
Marionette Mesh: from descriptive geometry to fabrication-aware design

This paper introduces an intuitive method for the modelling of free-form architecture with planar facets. The method, called Marionette by the authors, takes its inspiration from descriptive geometry and allows one to design complex shapes with one projection and the control of elevation curves. The proposed framework only deals with linear equations and therefore achieves exact planarity, for quadrilateral, Kagome, and dual Kagome meshes in real-time. Remarks on how this framework relates to continuous shape parameterisation and on possible applications to engineering problems are made. linearly on the altitude of the first point z ∗0 and on the altitudes of the points on the inner curve Z . It also depends on the in-plane projection of the strip. Formally, there exists a vector V and a scalar a , both functions of the plane view so that:
Clinical characteristics and outcomes of hospitalized COVID-19 patients with diabetes mellitus in East Java, Indonesia: A cross-sectional study [version 1; peer review: awaiting peer review]

Introduction : Diabetes mellitus has been perceived as the worsening factor for coronavirus disease 2019 (COVID-19), where diabetes mellitus patients with pre-existing inflammatory condition could develop acute respiratory disease syndrome as well as multi-organ dysfunction. Managing diabetes mellitus amidst severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is also a matter of concern as several antidiabetic therapies could affect the progression of COVID-19. This study aimed to provide the clinical characteristics and outcomes of patients with both COVID-19 and diabetes mellitus (2hPBG), and outcomes. Results : Most of the patients had age range of 41–60 years old (76.1%) with more than a half of the subjects (60%) were obese. Patients with uncontrolled diabetes were distributed evenly among the COVID-19 severities (74.3% in asymptomatic group, 73.6% in mild group, and 74.1% in moderate group). There were reductions in FBG and 2hPBG levels measured before (210.75±81.38 and 271.19±100.7 mg/dL, respectively) and after the treatment (181.03±68.9 and 222.01±86.96 mg/dL, respectively). All patients received multivitamin and symptomatic treatment for COVID-19. Oral antidiabetic drug (57.6%) and insulin (28.8%) were administered to lower the blood glucose level of the patients. As many as 96.9% patients survived, while 3.1% died. Conclusion : COVID-19 could affect the blood glucose level, suggesting the importance of antihyperglycemic therapies among patients with both COVID-19 and diabetes mellitus. of COVID-19 and massive was carried out. that early detection of SARS-CoV-2 could prevent the development and the progression of the
Learning Robust Image-Based Rendering on Sparse Scene Geometry via Depth Completion

Recent image-based rendering (IBR) methods usually adopt plenty of views to reconstruct dense scene geometry. However, the number of available views is limited in prac-tice. When only few views are provided, the performance of these methods drops off significantly, as the scene geometry becomes sparse as well. Therefore, in this paper, we propose Sparse-IBRNet (SIBRNet) to perform robust IBR on sparse scene geometry by depth completion. The SIBR-Net has two stages, geometry recovery (GR) stage and light blending (LB) stage. Specifically, GR stage takes sparse depth map and RGB as input to predict dense depth map by exploiting the correlation between two modals. As in-accuracy of the complete depth map may cause projection biases in the warping process, LB stage first uses a bias-corrected module (BCM) to rectify deviations, and then ag-gregates modified features from different views to render a novel view. Extensive experimental results demonstrate that our method performs best on sparse scene geometry than re-cent IBR methods, and it can generate better or comparable results as well when the geometric information is dense.1
ZAEBUC: An Annotated Arabic-English Bilingual Writer Corpus

We present ZAEBUC, an annotated Arabic-English bilingual writer corpus comprising short essays by first-year university students at Zayed University in the United Arab Emirates. We describe and discuss the various guidelines and pipeline processes we followed to create the annotations and quality check them. The annotations include spelling and grammar correction, morphological tokenization, Part-of-Speech tagging, lemmatization, and Common European Framework of Reference (CEFR) ratings. All of the annotations are done on Arabic and English texts using consistent guidelines as much as possible, with tracked alignments among the different annotations, and to the original raw texts. For morphological tokenization, POS tagging, and lemmatization, we use existing automatic annotation tools followed by manual correction. We also present various measurements and correlations with preliminary insights drawn from the data and annotations. The publicly available ZAEBUC corpus and its annotations are intended to be the stepping stones for additional annotations.
Analysis of water and sediment quality in Pacific whiteleg shrimp ( Litopenaeus vannamei ) culture on different sediment redox potential values

Water quality, soil, health, and growth observations are important for the pacific white leg shrimp culture. The correlation among these parameters is necessary for further determination and analysis. This study aimed to investigate the correlation among the various parameters of water quality, soil quality, technical coeffcient of shrimp culture, and shrimp health parameters in shrimp culture activities with different sediment redox potential values. This study was conducted with different sediment redox potential values, namely 69.33 ± 14.5 mV, 151.00 ± 8.89 mV, and 210.00 ± 17.32 mV with four replications. The 25 shrimps with an average weight of 1.37 ± 0.04 g and a stocking density of 144 shrimp/m2 were used in the study for 30 days. During the study, the parameters included water quality, health, and growth parameters. The water quality parameters did not show significant differences among treatments, except pH and dissolved oxygen values. At a low redox potential, the pH value tended to be higher, while the dissolved oxygen value was higher, following the higher redox potential value. The water quality parameters
ET tu, CLIP? Addressing Common Object Errors for Unseen Environments

We introduce a simple method that employs pre-trained CLIP encoders to enhance model generalization in the AL-FRED task. In contrast to previous literature where CLIP replaces the visual encoder, we suggest using CLIP as an additional module through an auxiliary object detection ob-jective. We validate our method on the recently proposed Episodic Transformer architecture and demonstrate that incorporating CLIP improves task performance on the unseen validation set. Additionally, our analysis results support that CLIP especially helps with leveraging object descriptions, detecting small objects, and interpreting rare words
Supplementary Material: Learning to Find Good Models in RANSAC

We show the detailed architecture of MF-Net in Figure 1. We design MF-Net as a lightweight network architecture for early detection of degenerate minimal samples. The main design principle is the incorporation of many invariances in the task: we normalize the points in each image, then we process the correspondences from image I1 to I2 and the opposite from I2 to I1 in two parallel shared branches of the network. Each branch follows the PointNet [4] design to achieve correspondence ordering invariance. Finally, features from the two branches are merged in a global feature, and classification is performed by a final MLP. All MLPs in the figure have a single hidden layer and use leaky relu activation function with negative slope 0.01, except for the final activation function using the sigmoid function. The dimensionality of their representations, visible on top of each MLP in the figure, do not exceed 64 to keep the computation lightweight and, thus, fast. We implement the normalization by subtracting the mean per-channel for essential matrix estimation, and additionally we divide by the per-channel standard deviation for fundamental matrix estimation since in this case the input points are expressed in pixel coordinates instead of standardized image coordinates. Note that, while the architecture supports general n-samples of correspondences, we train it consistently with minimal samples only (i.e., n = 5 for essential matrix estimation and n = 7 for fundamental matrix estimation).