Miracle-dz/UniFAR-FTUs huggingface dataset:
Colorectal Carcinoma in Children and Adolescents in Low Middle Income Countries: Single Center Experience

Colorectal carcinoma (CRC) is rare in children with extremely poor prognosis. Proper management is obscure because of deficient data. The aim of the current study is to assess the clinical characteristics and to determine the different prognostic factors leading to dismal outcome. It is a retrospective study included all CRC patients, below 18 years, treated in Children’s Cancer Hospital of Egypt (CCHE) between 2007 and 2016. Demographic data, clinical characteristics, diagnostics, histological subtypes, disease stage, treatment methods, and survival outcome were collected. The result showed that, 15 patients below 18 years. All had unfavorable histopathology (mucinous adenocarcinoma) and 10 cases had metastatic disease. Initial surgical resection was done in 8/15 cases, all patients received neo adjuvant/adjuvant chemotherapy. Four patients had rectal adenocarcinoma and were treated with chemo-radiotherapy while 11 had colonic adenocarcinoma. Ten patients had progression or relapse, while 12 died at the end of follow up period; 3-years Overall Survival (OS) and Event Free Survival (EFS) were 17.8% and 16.5% respectively, the only three surviving patients were of lower stage disease. In Conclusions, Clinical presentation of CRC in pediatrics is similar to adults but delayed diagnosis and advanced stages contribute to poor outcome which is due to the absence of familiarity to CRC. The high frequency of mucinous adenocarcinoma may explain the poor outcome. Surgery remains the mainstay of treatment as in adults. Preoperative radiotherapy for rectal adenocarcinoma, offers better prognosis. Chemotherapy plays a role in the metastatic disease and can downstage the primary tumor for better local control.
Clinical utility of Immature granulocyte percentage and NLR in Critical care unit patients in a tertiary care hospital

Immature granulocytes such as myelocytes, promyelocytes, and metamyelocytes are the precursors of WBC. These cells increased during bacterial infection in bloodstream, bone marrow activity, or in sepsis. Neutrophils, monocytes, and lymphocytes play crucial role in systemic inflammatory response to severe infection. Neutrophilia and lymphocytopenia are physiological response of innate immunity system to systemic inflammation, injury and stress. This study is aimed to evaluate the significance of Immature granulocyte percentage and NLR among the ICU patients when compared to the NON-ICU patients. The study included 174 patients of non critical admitted in ward and 20 patients admitted in critical ICU care. The statistical analysis is done for the haematological parameters among the ICU and NON-ICU patients by using Independent samples ttest. The mean value of Immature granulocyte percentage, NLR, WBC count and ANC among the ICU patients is high, showing the statistical significance of p<0.05, when compared to NON-ICU patients. Hence IG%, NLR along with routine WBC count and ANC are effective markers in predicting the severity of infection in critical ill patients and need for the earlier intervention
Cellocity: A Python package for analysis of confluent cell layer dynamics

Studying the coordinated cell and tissue movements within confluent cell layers can give insights into diverse biological phenomena, such as wound healing, cancer cell metastasis, and host cell responses to infection. Cellular dynamics studies typically rely on analysis of time lapse images, generated by live cell microscopy. As a result of recent progress in stem cell and developmental biology, it is now often possible to generate confluent cell layers of primary cells that recapitulate central features of intact tissues (Dutton et al., 2019). However, one disadvantage of such primary cell model systems is that it remains technically challenging to generate and image fluorescently labeled live samples. This complicates the use of segmentation and single-particle tracking as a means to study cellular movements (Danuser & Waterman-Storer, 2006). Consequently, optical flow-based analysis of bright field (black and white) microscopy images provides a competitive method to extract cell dynamics information from such sensitive and low-contrast experimental model systems (Vig et al., 2016). Because the study of confluent cell layer dynamics lies at the intersection of biophysics and cell biology, two research communities with different emphasis on mathematics, there is a need for a simple and easy-to-use framework that performs and visualizes Optical Flow analysis of microscopy data. We here present Cellocity, a Python package for Optical Flow and Particle Image Velocimetry (PIV) analysis, specifically catering to the bioimaging community.
The implementation of social innovations : A multiple case study among international new ventures in developing and developed countries

3 Chapter 1 – Introduction . 4 Chapter 2 – Literature Review . 8 2.1. Social Innovations . 8 2.1. 1. Definition social innovation . 8 2.1. 2. Phases of social innovation . 10 2.2 Institutional environment . 11 2.2.1 Definition of institutional environment . 11 2.2.2. Institutional strategies . 13 2.3 International New Ventures . 18 2.3.1 Definition of INVs . 18 2.4 Theoretical Framework . 20 Chapter 3 – Methodology . 27 3.1 Research design . 27 3.2 Case selection . 28 3.3 Data collection . 31 3.5 Data validity and reliability . 32 3.6 Research Ethics . 33 Chapter 4 – Results . 34 4.1 Within-case analysis . 34 4.1. 1 Sweepsmart . 34 4.1. 2 Wateroam . 39 4.1. 3 Hello Tractor . 44 4.1. 4 OrCam . 48 4.1. 5 Walk With Path . 52 4.1. 6 Case 6: Quicargo . 56 4.2 Cross-case analysis . 59 Chapter 5 – Discussion . 64 5.1 Discussion of the findings . 64 5.2 Theoretical contributions and managerial implications . 73 5.3 Limitations and future research . 75 Chapter 6 – Conclusion . 77 Reference List . 79 Appendix I – Interview Questions . 93
Development of Microfinance Organisations in Vietnam

The aim of this paper is to examine the development of microfinance in Vietnam from the early 1980s. This provides a particularly interesting case study in view of the large-scale changes that have taken place in the economy over the period, which has experienced the transition from a Central Economic Planning System towards a ‘socialist-oriented market economy’, with increased integration in the world economy. Starting from a framework, or taxonomy, of microfinance organisations, the paper explores how the two main objectives of microfinance organisations - of meeting the economic needs of borrowers and being sustainable - have eventually been met using a diversity of organisational forms.
An extension of relativist attitude reports

Relativist compositional semantic frameworks have often been motivated by the desire to do justice to a notion of faultless disagreement, but a clear exposition of this notion, and a demonstration that these compositional frameworks capture it, has remained elusive. This work elucidates and extends the relativist tradition through the examination of its treatment of belief reports, in two steps: (i), by showing how a relativist semantics as already proposed in the literature allows for a straightforward and substantive notion of faultless disagreement cast in terms of belief; and (ii), by showing that this notion is applicable to a far wider range of cases than have been historically treated by relativists, but to which the relativist framework can extend. I demonstrate that a relativist semantics captures this notion of faultless disagreement by allowing that distinct agents can incur distinct descriptive commitments as to how the world is in virtue of believing the same thing, and then show that a novel interpretation of the relativist notion of perspectivesensitivity, in terms of the factual conditions under which an agent is willing to apply an expression, rightly allows for the characterization of faultless disagreement as a ubiquitous phenomenon not triggered by a special class of predicates.
Complete mitochondrial genome sequence of Lepus yarkandensis Günther, 1875 (Lagomorpha, Leporidae): characterization and phylogenetic analysis

Abstract Lepus yarkandensis is a national second-class protected animal endemic to China and distributed only in the hot and arid Tarim Basin in Xinjiang. We sequenced and described the complete mitogenome of L. yarkandensis to analyze its characteristics and phylogeny. The species’ DNA is a 17,047 bp circular molecule that includes 13 protein-coding genes (PCGs), two rRNA genes, 22 tRNA genes, and one control region. The overall base composition was as follows: A, 31.50%; T, 29.40%; G, 13.30% and C, 25.80%, with a high A+T bias of 60.9%. In the PCGs, ND6 had deviation ranges for AT skew (–0.303) and GC skew (0.636). The Ka/Ks values of ND1 (1.067) and ND6 (1.352) genes were >1, indicating positive selection, which might play an important role in the adaptation of L. yarkandensis to arid and hot environments. The conserved sequence block, the central conserved domain, and the extended termination-associated sequences of the control region and their features were identiﬁed and described. The phylogenetic tree based on the complete mitogenome showed that L. yarkandensis was closely related to the sympatric Lepus tibetanus pamirensis. These novel datasets of L. yarkandensis can supply basic data for phylogenetic studies of Lepus spp. , apart from providing essential and important resource for further genetic research and the protection of this species.
Munich Personal RePEc Archive ( Ir ) rational Voters ?

Social scientists have long speculated about the extent of agents’ rationality, especially in the context of voting. However, existing attempts at classifying voters as (ir)rational have been hampered by the fact that preference orderings and, thus, optimal strategies are generally unobserved. Exploiting the incentive structure of Germany’s electoral system, this paper develops a novel set of empirical tests in order to pit the canonical rational choice model against behavioral theories according to which voters simply choose their most preferred candidate. The results indicate that neither approach can rationalize the most-salient features of the data. The findings are consistent, however, with a simple hybrid model in which boundedly rational agents suffer a small psychic cost from acting strategically. Previous versions of this paper circulated under the title “On the Extent of Strategic Voting. ” I am especially grateful to Gary Becker, Roland Fryer, Steven Levitt, and Roger Myerson. Moreover, I have benefitted from comments by Daron Acemoglu, Scott Ashworth, Daniel Benjamin, Eric Budish, Ethan Bueno de Mesquita, Francesco Caselli, Dana Chandler, Steve Coate, Tony Cookson, Daniel Diermeier, Will Dobbie, Tim Feddersen, Amy Finkelstein, Alex Frankel, Richard Holden, Antonio Merlo, Kenneth Mirkin, Francesca Molinari, Matthew Notowidigdo, Elisa Olivieri, Nicola Persico, Jesse Shapiro, Jan Stoop, Philipp Tillmann, David Toniatti, Yasutora Watanabe, and Richard Van Weelden, as well as audiences at the AEA, EEA, and MPSA Meetings, the Calvó-Armengol Prize Workshop (Barcelona GSE), Columbia, Cornell, the Gaming and Learning in Incentive Systems Conference (Boston University), Kellogg, LSE, MIT, the Princeton Conference on Political Economy, University of Chicago, and Wharton. I am also indebted to Gabriele Schömel at the office of the Bundeswahlleiter for assistance in acquiring the data used in this paper. Steven Castongia provided excellent research assistance. Financial support from the Beryl W. Sprinkel Fund at the University of Chicago is gratefully acknowledged. All views expressed in this paper as well as any remaining errors are solely my responsibility. Correspondence can be addressed to the author at MEDS Department, Kellogg School of Management, 2001 Sheridan Road, Evanston, IL 60208, or by e-mail: j-spenkuch@kellogg.northwestern. edu.
For One and All: Individual and Group Fairness in the Allocation of Indivisible Goods

Fair allocation of indivisible goods is a well-explored problem. Traditionally, research focused on individual fairness - are individual agents satisfied with their allotted share? - and group fairness - are groups of agents treated fairly? In this paper, we explore the coexistence of individual envy-freeness (i-EF) and its group counterpart, group weighted envy-freeness (g-WEF), in the allocation of indivisible goods. We propose several polynomial-time algorithms that provably achieve i-EF and g-WEF simultaneously in various degrees of approximation under three different conditions on the agents' (i) when agents have identical additive valuation functions, i-EFX and i-WEF1 can be achieved simultaneously; (ii) when agents within a group share a common valuation function, an allocation satisfying both i-EF1 and g-WEF1 exists; and (iii) when agents' valuations for goods within a group differ, we show that while maintaining i-EF1, we can achieve a 1/3-approximation to ex-ante g-WEF1. Our results thus provide a first step towards connecting individual and group fairness in the allocation of indivisible goods, in hopes of its useful application to domains requiring the reconciliation of diversity with individual demands.
The microRNA390/TAS3 pathway mediates in symbiotic nodulation and lateral root growth

1 1 The microRNA390/TAS3 pathway mediates in symbiotic nodulation and 2 lateral root growth 3 Karen Vanesa Hobecker, Mauricio Alberto Reynoso, Pilar Bustos-Sanmamed, 4 Jiangqi Wen, Kirankumar S. Mysore, Martín Crespi, Flavio Antonio Blanco, María 5 Eugenia Zanetti 6 7 a Instituto de Biotecnología y Biología Molecular, FCE-UNLP CCT-CONICET, Calle 8 115 y 47, C.P. 1900, La Plata, Argentina. 9 b Institute of Plant Sciences Paris-Saclay (IPS2), CNRS, INRA, Universités Paris-Sud, 10 Evry, Paris-Diderot, , Université Paris-Saclay, Bâtiment 630, 91405 0rsay, France. 11 c Plant Biology Division, The Samuel Roberts Noble Foundation, Ardmore, Oklahoma 12 73401, USA. 13 14 ORCID ID: 0000-0002-9990-5808 (M.A.R); 0000-0001-5510-5318 (P.B.S.); 0000-000115 5113-7750 (J.W.); 0000-0002-9805-5741 (K.S.M.); 0000-0002-0310-216 (M.C.); 000016 0002-8380-8472 (F.A.B); 0000-0001-9565-1743 (M.E.Z.) 17 18 1 Address correspondence to ezanetti@biol.unlp. edu.ar 19 § Present address: Center for Plant Cell Biology, University of California, Riverside, CA 20 USA. 21 £ Present address: Universidad de Salamanca, Salamanca, Spain. 22 23 Running title: miR390 in lateral root growth and nodulation 24 25 Summary: miR390/TAS3 affect rhizobial infection, nodule proliferation and 26 maintenance of a single nodule meristem in addition to lateral root growth in 27 Medicago 28 29 Plant Physiology Preview. Published on June 29, 2017, as DOI:10.1104/pp.17. 00464
Geospatial analyzing of straits shipping paths for the integration of air quality and marine wildlife conservation

This paper develops a GIS-based model to determine suitable locations for shipping paths within Malacca Strait by investigating the best air quality. The mathematical and geospatial approach is used to identify a reasonable relationship between air quality and Dugong's habitat location. Various factors with different levels of influence and degrees of importance were established as criteria. The chosen region of study, Malacca Strait, the world's second-busiest commercial shipping channel, undertakes several statistical and mathematical analyses of vessel transportation that focus on air quality concerning the main marine animal of Strait (Dugong), using the geographic information system (GIS) as a visualization platform. The distance from the maritime paths to the dugong home range is modeled based on NOx's factor as the primary air pollutant of shipping emissions from moving vessels in the sea. The results took into consideration the main negative environmental elements in shipping paths. The minimum calculated distance serves as a constraint to indicate where the dugongs' habitats cannot be located. The result is that too many parts of the probability of suitable Dugong habitat in the study area do not have a proper position that does not put it in conflict with shipping polluted zones. This research has successfully managed and developed a scientifically based method for understanding the relationship between wide life habitat and marine transportation by analyzing successful and non-successful present and future shipping.
HairTouch: Providing Stiffness, Roughness and Surface Height Differences Using Reconfigurable Brush Hairs on a VR Controller

Tactile feedback is widely used to enhance realism in virtual reality (VR). When touching virtual objects, stiffness and roughness are common and obvious factors perceived by the users. Furthermore, when touching a surface with complicated surface structure, differences from not only stiffness and roughness but also surface height are crucial. To integrate these factors, we propose a pin-based handheld device, HairTouch, to provide stiffness differences, roughness differences, surface height differences and their combinations. HairTouch consists of two pins for the two finger segments close to the index fingertip, respectively. By controlling brush hairs’ length and bending direction to change the hairs’ elasticity and hair tip direction, each pin renders various stiffness and roughness, respectively. By further independently controlling the hairs’ configuration and pins’ height, versatile stiffness, roughness and surface height differences are achieved. We conducted a perception study to realize users’ distinguishability of stiffness and roughness on each of the segments. Based on the results, we performed a VR experience study to verify that the tactile feedback from HairTouch enhances VR realism.
On the Efficiency of Some Alpha Diversity Indices: A Simulation Study Using Bootstrap Resampling

It is essential to measure biodiversity to determine the stability of a community of species. A good measure gives precise, reliable, and efficient information about the community structure. This study was conducted to evaluate the statistical properties and test some alpha diversity indices' efficiency through a bootstrap resampling. The available birds' data were being applied in some alpha diversity indices. Moreover, the Shapiro-Wilk test is being used to test the normality of the index. All indices analyzed have p-values higher than the alpha level of significance (α=0.05), indicating that the index's bootstrap sampling distribution is normally distributed. Mostly, all indices are consistently efficient at large sample sizes. The Menhinick richness index is more efficient in measuring birds' species richness since it has the smallest means squared error (MSE) values. Among the diversity indices studied in this paper, Simpson's diversity index generated smaller mean squared error (MSE) values; thus, it is a more efficient diversity index in measuring birds' diversity. The Shannon evenness index is more efficient among the five evenness indices in measuring species evenness of birds because it provides the smaller MSE values.
University of Birmingham ESTPiper--a web-based analysis pipeline for expressed sequence tags

Background: EST sequencing projects are increasing in scale and scope as the genome sequencing technologies migrate from core sequencing centers to individual research laboratories. Effectively, generating EST data is no longer a bottleneck for investigators. However, processing large amounts of EST data remains a non-trivial challenge for many. Web-based EST analysis tools are proving to be the most convenient option for biologists when performing their analysis, so these tools must continuously improve on their utility to keep in step with the growing needs of research communities. We have developed a web-based EST analysis pipeline called ESTPiper, which streamlines typical large-scale EST analysis components. Results: The intuitive web interface guides users through each step of base calling, data cleaning, assembly, genome alignment, annotation, analysis of gene ontology (GO), and microarray oligonucleotide probe design. Each step is modularized. Therefore, a user can execute them separately or together in batch mode. In addition, the user has control over the parameters used by the underlying programs. Extensive documentation of ESTPiper's functionality is embedded throughout the web site to facilitate understanding of the required input and interpretation of the computational results. The user can also download intermediate results and port files to separate programs for further analysis. In addition, our server provides a time-stamped description of the run history for reproducibility. The
ON DISTRIBUTED FUZZY DECISION TREES FOR BIG DATA

:- We present a definition of a Fuzzy Prolog Language that models interval-valued Fuzzy Logic, and subsumes former approaches because it uses a truth value representation based on a union of intervals of real numbers and it is defined using general operators that can model different logics. We give the declarative and procedural semantics for Fuzzy Logic programs. In addition, we present the implementation of an interpreter for this language conceived using CLP(R). We have incorporated uncertainty into a Prolog system in a simple way thanks to this constraints system. The implementation is based on a syntactic expansion of the source code during the Prolog compilation.
Towards Joint Cell Selection and Task Ofﬂoading in Cellular IoT Systems with Edge Computing

—Mobile Edge Computing (MEC) in cellular networks aims to bring computational capabilities close to end-users to reduce the latency of applications on the Internet of Things (IoT). This is particularly crucial to computation-intensive IoT broadband applications (e.g., video analytics, augmented reality, etc.) demanding a data processing task to be performed within a given time threshold. In this regard, the task ofﬂoading problem has been investigated in the literature in order to achieve an appropriate trade-off between energy and latency. However, there is a need for the joint design of task ofﬂoading mechanisms and cell selection algorithm as a mean to select the most appropriate to each device in order to meet delay requirements and fulﬁll resource constraints at the MEC server site. In this paper, we present the foreseen framework to tackle such a challenging problem.
Rhomboideus muscle fatty acid profile in advancing age of zebu cattle ( Bos indicus )

The lipid content in muscle tissue confers flavor and other sensory attributes affecting meat tenderness. In this study, we evaluated the changes of fatty acids profile in the Nelore Rhomboideus m. (RB) having Longissimus dorsi (LD) of the same animal for comparison. We used muscle samples in triplicate of three male animals (n=9), aged 18, 24, 36 and 48 months. Whilst for RH, the changes in the lipid content were completely random varying from 3.76% to 50.39% irrespective of animal age, for LD, the lipid amount decreased proportionally with ageing of 3.28<2.83<2.08<1.75, respectively. This result for RH reflects the variability of the muscle in relation to season and management of the animals while in the farm. In relation to n-6/n-3 ratio the RH samples presented values ranging from 7.40 at 18mo of age to 1.52 at 48mo of age while LD samples changed from 1.68 at 24mo of age to 10.74 at 36mo, being the exception of the animals 18mo of age for RB and 36mo for LD, this ratio is lower than 3:1. The MUFA for both RB and LD presented a range of 37 to 50%. The ratio PUFA/SFA, ranged from 0.050 and 0.080 for both muscles irrespective of ageing. We concluded that Rhomboideus m. presented similar fatty acids nutritional quality of Longissimus dorsi m. Keywords, rhomboideus muscle, nelore catle, fatty matter