Miracle-dz/UniFAR-FTUs huggingface dataset:
An Analysis of the Effect of ZIF-8 Addition on the Separation Properties of Polysulfone at Various Temperatures

The transport of H2, He, CO2, O2, CH4, and N2 at three temperatures up to 65 °C was measured in dense, thick composite films formed by amorphous Polysulfone (PSf) and particles of the size-selective zeolitic imidazolate framework 8 (ZIF-8) at loadings up to 16 wt%. The morphological and structural properties of the membranes were analyzed via SEM and density measurement. The addition of ZIF-8 to PSf enhances the H2 and He permeabilities up to 480% with respect to the pure polymer, while the ideal H2/CO2 and He/CO2 selectivities of MMMs reach values up to 30–40% higher than those of pure PSf. The relative permeability and diffusivity enhancements are higher than those obtained in other polymers, such as PPO, with the same amount of filler. The Maxwell–Wagner–Sillars model is able to represent the MMM H2/CO2 separation performance for filler volume fractions below 10%.
From Fear to Hopelessness: The Buffering Effect of Patient-Centered Communication in a Sample of Oncological Patients during COVID-19

Background: COVID-19 represents a threat both for the physical and psychological health of oncological patients experiencing heightened distress levels to which the fear of the virus is also added. Moreover, fear of COVID-19 could lead oncological patients to experience feelings of hopelessness related to their medical care. Patient-centered communication may act as a buffer against the aforementioned variables. This study aimed to test the role of doctor–patient communication in the relationship between fear of COVID-19 and hopelessness. Methods: During the COVID-19 pandemic, a sample of 90 oncological outpatients was recruited (40 males (44.4%) and 50 females (55.6%), mean age = 66.08 (SD = 12.12)). A structured interview was developed and used during the pandemic to measure the patients’ perceived (A) fear of COVID-19, and (B) feelings of hopelessness, and (C) physicians’ use of empathetic and (D) clear language during the consultation. A multiple mediation model was tested, and the effects between males and females were also compared. Results: Empathetic and clear doctor–patient communication buffered the adverse effect of the fear of COVID-19 on hopelessness through a full-mediation model. The effects did not differ between males and females in the overall model but its indirect effects. Discussions: Patient-centered communication using empathy and clear language can buffer the adverse effect of the fear of COVID-19 and protect oncological patients from hopelessness during the pandemic. These findings might help to improve clinical oncological practice.
Structural and Functional Impacts of Microbiota on Pyropia yezoensis and Surrounding Seawater in Cultivation Farms along Coastal Areas of the Yellow Sea

Pyropia yezoensis is the most important commercial edible red algae in China, carrying a variety of resident microbes at its surface. To understand microbiome diversity, community structure, interactions and functions with hosts in this regard, thalli and seawater sampleswere collected from Yantai and Rizhao cultivation farms in the Yellow Sea. The thalli and seawater samples (n = 12) were collected and studied using an Illumina NovaSeq 6000 platform and 16S ribosomal RNA (rRNA) gene sequencing, along with the consideration of environmental factors. Bacterial communities in association with P. yezoensis and surrounding seawater were predominated by Cyanobacteria, Proteobacteria, and Bacteroidetes. The variability of bacterial communities related to P. yezoensis and seawater were predominantly shaped by nitrate (NO3), ammonium (NH4), and temperature. Cluster analysis revealed a close relationship between thalli (RTH and YTH) and seawater (RSW and YSW) in terms of the residing bacterial communities, respectively. PICRUSt analysis revealed the presence of genes associated with amino acid transportation and metabolism, which explained the bacterial dependence on algal-provided nutrients. This study reveals that the diversity of microbiota for P. yezoensis is greatly influenced by abiotic factors and algal organic exudates which trigger chemical signaling and transportation responses from the bacterial community, which in turn activates genes to metabolize subsequent substrates.
Rubbery-Modified CFRPs with Improved Mode I Fracture Toughness: Effect of Nanofibrous Mat Grammage and Positioning on Tanδ Behaviour

Carbon Fiber Reinforced Polymers (CFRPs) are widely used where high mechanical performance and lightweight are required. However, they suffer from delamination and low damping, severely affecting laminate reliability during the service life of components. CFRP laminates modified by rubbery nanofibers interleaving is a recently introduced way to increase material damping and to improve delamination resistance. In this work, nitrile butadiene rubber/poly(ε-caprolactone) (NBR/PCL) blend rubbery nanofibrous mats with 60 wt% NBR were produced in three different mat grammages (5, 10 and 20 g/m2) via single-needle electrospinning and integrated into epoxy CFRP laminates. The investigation demonstrated that both mat grammage and positioning affect CFRP tanδ behaviour, evaluated by dynamic mechanical analysis (DMA) tests, as well as the number of nano-modified interleaves. Double cantilever beam (DCB) tests were carried out to assess the mat grammage effect on the interlaminar fracture toughness. Results show an outstanding improvement of GI,R for all the tested reinforced laminates regardless of the mat grammage (from +140% to +238%), while the effect on GI,C is more dependent on it (up to +140%). The obtained results disclose the great capability of NBR/PCL rubbery nanofibrous mats at improving CFRP damping and interlaminar fracture toughness. Moreover, CFRP damping can be tailored by choosing the number and positioning of the nano-modified interleaves, besides choosing the mat grammage.
Frailty Level Classification of the Community Elderly Using Microsoft Kinect-Based Skeleton Pose: A Machine Learning Approach

Frailty is one of the most important geriatric syndromes, which can be associated with increased risk for incident disability and hospitalization. Developing a real-time classification model of elderly frailty level could be beneficial for designing a clinical predictive assessment tool. Hence, the objective of this study was to predict the elderly frailty level utilizing the machine learning approach on skeleton data acquired from a Kinect sensor. Seven hundred and eighty-seven community elderly were recruited in this study. The Kinect data were acquired from the elderly performing different functional assessment exercises including: (1) 30-s arm curl; (2) 30-s chair sit-to-stand; (3) 2-min step; and (4) gait analysis tests. The proposed methodology was successfully validated by gender classification with accuracies up to 84 percent. Regarding frailty level evaluation and prediction, the results indicated that support vector classifier (SVC) and multi-layer perceptron (MLP) are the most successful estimators in prediction of the Fried’s frailty level with median accuracies up to 97.5 percent. The high level of accuracy achieved with the proposed methodology indicates that ML modeling can identify the risk of frailty in elderly individuals based on evaluating the real-time skeletal movements using the Kinect sensor.
Differences in the Effects of Anthocyanin Supplementation on Glucose and Lipid Metabolism According to the Structure of the Main Anthocyanin: A Meta-Analysis of Randomized Controlled Trials

The effectiveness of anthocyanins may differ according to their chemical structures; however, randomized clinical controlled trials (RCTs) or meta-analyses that examine the consequences of these structural differences have not been reported yet. In this meta-analysis, anthocyanins in test foods of 18 selected RCTs were categorized into three types: cyanidin-, delphinidin-, and malvidin-based. Delphinidin-based anthocyanins demonstrated significant effects on triglycerides (mean difference (MD): −0.24, p < 0.01), low-density lipoprotein cholesterol (LDL-C) (MD: −0.28, p < 0.001), and high-density lipoprotein cholesterol (HDL-C) (MD: 0.11, p < 0.01), whereas no significant effects were observed for cyanidin- and malvidin-based anthocyanins. Although non-significant, favorable effects on total cholesterol (TC) and HDL-C were observed for cyanidin- and malvidin-based anthocyanins, respectively (both p < 0.1). The ascending order of effectiveness on TC and LDL-C was delphinidin-, cyanidin-, and malvidin-based anthocyanins, and the differences among the three groups were significant (both p < 0.05). We could not confirm the significant effects of each main anthocyanin on glucose metabolism; however, insulin resistance index changed positively and negatively with cyanidin- and delphinidin-based anthocyanins, respectively. Therefore, foods containing mainly unmethylated anthocyanins, especially with large numbers of OH groups, may improve glucose and lipid metabolism more effectively than those containing methylated anthocyanins.
Two-Stage Conversion of Low-Rank Coal or Biomass into Liquid Fuel under Mild Conditions

The authors have recently proposed a novel degradative solvent extraction method that upgrades and fractionates various types of low-rank coals or biomass wastes into several different molecular weight fractions at around 350 °C. The lowest molecular weight fraction that was recovered as solid (termed soluble) by the yield of 19.4–71.7 wt % on a carbon basis had unique and almost raw-material-independent properties: almost free from ash and moisture, average molecular weight of around 300, carbon content of as high as 81.5–84.8 wt %, and oxygen content of as low as 6.5–12.1 wt %. In this work, the combination of the proposed extraction method and the liquefaction of the soluble under mild conditions was investigated as a two-stage liquefaction method to produce liquid fuel. A rice straw (RS) and a brown coal (LY) were extracted by the proposed extraction method to produce solubles by the yields of 31.5 and 21.7 wt %, respectively. The solubles produced were then liquefied at 400 °C using FeOOH/sulfur as t.
RTLIO: Real-Time LiDAR-Inertial Odometry and Mapping for UAVs

Most UAVs rely on GPS for localization in an outdoor environment. However, in GPS-denied environment, other sources of localization are required for UAVs to conduct feedback control and navigation. LiDAR has been used for indoor localization, but the sampling rate is usually too low for feedback control of UAVs. To compensate this drawback, IMU sensors are usually fused to generate high-frequency odometry, with only few extra computation resources. To achieve this goal, a real-time LiDAR inertial odometer system (RTLIO) is developed in this work to generate high-precision and high-frequency odometry for the feedback control of UAVs in an indoor environment, and this is achieved by solving cost functions that consist of the LiDAR and IMU residuals. Compared to the traditional LIO approach, the initialization process of the developed RTLIO can be achieved, even when the device is stationary. To further reduce the accumulated pose errors, loop closure and pose-graph optimization are also developed in RTLIO. To demonstrate the efficacy of the developed RTLIO, experiments with long-range trajectory are conducted, and the results indicate that the RTLIO can outperform LIO with a smaller drift. Experiments with odometry benchmark dataset (i.e., KITTI) are also conducted to compare the performance with other methods, and the results show that the RTLIO can outperform ALOAM and LOAM in terms of exhibiting a smaller time delay and greater position accuracy.
Mucoadhesive Delivery System: A Smart Way to Improve Bioavailability of Nutraceuticals

The conventional oral administration of many nutraceuticals exhibits poor oral bioavailability due to the harsh gastric conditions and first-pass metabolism. Oral mucosa has been recognized as a potential site for the delivery of therapeutic compounds. The mucoadhesive formulation can adhere to the mucosal membrane through various interaction mechanisms and enhance the retention and permeability of bioactive compounds. Absorption of bioactive compounds from the mucosa can improve bioavailability, as this route bypasses the hepatic first-pass metabolism and transit through the gastrointestinal tract. The mucosal administration is convenient, simple to access, and reported for increasing the bioactive concentration in plasma. Many mucoadhesive polymers, emulsifiers, thickeners used for the pharmaceutical formulation are accepted in the food sector. Introducing mucoadhesive formulations specific to the nutraceutical sector will be a game-changer as we are still looking for different ways to improve the bioavailability of many bioactive compounds. This article describes the overview of buccal mucosa, the concept of mucoadhesion and related theories, and different techniques of mucoadhesive formulations. Finally, the classification of mucoadhesive polymers and the mucoadhesive systems designed for the effective delivery of bioactive compounds are presented.
Evaluation of the Inclusion of the Green Seaweed Ulva ohnoi as an Ingredient in Feeds for Gilthead Sea Bream (Sparus aurata) and European Sea Bass (Dicentrarchus labrax)

Simple Summary The use of seaweeds in aquafeeds is receiving increasing attention due to their potential nutritional and functional benefits. However, several green seaweeds such as Ulva presents nutritional limitations because of the undigestible polysaccharides, although these may exert a positive effect on the immunological status of the fish. The present study developed three different experiments aimed to re-evaluate the presence of protease inhibitors described for Ulva ohnoi, to assess its nutritional value as an ingredient and also to evaluate its potential protective effect on the oxidative metabolism of fish, being experiments developed in two different fish species (European sea bass Dicentrarchus labrax and gilthead sea bream, Sparus aurata). Results indicate the absence of negative effects of U. ohnoi on protein digestion of sea bream but a limited value as a feed ingredient. In contrast, its contents in bioactives seem to be correlated to the observed positive effects on the immune status and oxidative metabolism when fish are challenged by the consumption of highly oxidized dietary oil. Abstract This study evaluated the use of Ulva ohnoi as an ingredient in feeds for aquaculture in three different experiments. Experiment 1 was oriented to confirm the negative effect of U. ohnoi on fish digestion. Experiment 2 assessed the effect on growth, feed efficiency, and immune status of juvenile sea bass (Dicentrarchus labrax) fed on diets including U. ohnoi, previously treated or not with carbohydrases used to partially hydrolyze indigestible polysaccharides. Experiment 3 was aimed to evaluate the potential protective effect of U. ohnoi on the oxidative status of sea bream (Sparus aurata) challenged by the consumption of a feed formulated with the oil fraction completely oxidized. Results show a negligible effect of U. ohnoi meal on protein digestion when included in feeds at levels of 10% or less. Moreover, results of growth and feed use evidenced the possibility of using up to 5% inclusion of algal meal in feeds without adverse effects on the zootechnical parameters, while the enzyme pretreatment was ineffective to improve its nutritional use. Finally, the inclusion of U. onhoi in feeds determined both an immunostimulatory effect, evidenced by an increase in skin mucus lysozyme in the two mentioned fish species, and a positive influence on the oxidative metabolism of seabream when fed on a diet including rancid oil.
Safe-by-design development of a topical patch for drug delivery

Few topical products have been developed specifically to treat acute and chronic arthritis and inflammation, using non-steroidal anti-inflammatory drugs (NSAIDs). The lack of dosing accuracy commonly found in locally applied semisolid products for cutaneous use is a critical issue that leads to treatment failure. The aim of the present work is to develop a differentiated and innovative topical patch based on a monolithic hydrogel for ibuprofen skin delivery, in order to provide a safer and accurate way of drug administration along with improved treatment compliance. Topical patches based on hydroxypropylmethylcellulose (HPMC) were optimized in composition, in terms of enhancer and adhesive, supported on a systematic assessment of in vitro release and permeation behavior and adhesion properties. Several mathematical models were used to scrutinize the release mechanisms from the patches. In vitro release kinetics was shown to be mainly driven by diffusion. However, other mechanisms seemed to be also present, supporting the feasibility of using patches for sustained drug delivery. PEG 200 provided the best permeation rate, with a permeation enhancement ratio of ca. 3 times higher, than the commercial reference. The addition of Eudragit L30D 55 to the formulation led to the best adhesion profile, thus achieving a successful development based on a safe-by-design concept.
A new semi-analytical model for effective thermal conductivity of nanofluids

ABSTRACT A new theoretical model for thermal conductivity of nanofluids is developed incorporating effective medium theory, interfacial layer, particle aggregation and Brownian motion-induced convection from multiple nanoparticles/aggregates. The predicated result using aggregate size, which represents the particle size in the actual condition of nanofluids, fits well with the experimental data for water-, R113- and ethylene glycol (EG)-based nanofluids. The present model also gives much better predictions compared to the existing models. A parametric analysis, particularly particle aggregation, is conducted to investigate the dependence of effective thermal conductivity of nanofluids on the properties of nanoparticles and fluid. Aggregation is the main factor responsible for thermal conductivity enhancement. The dynamic contribution of Brownian motion on thermal conductivity enhancement is surpassed by that of static mechanisms, particularly at high volume fraction. Predication also indicated that the viscosity increases faster than the thermal conductivity, causing the highly aggregated nanofluids to become unfavourable, especially for df = 1.8.
Prenatal intake of omega‐3 promotes Wnt/β‐catenin signaling pathway, and preserves integrity of the blood–brain barrier in preeclamptic rats

Preeclampsia is a systemic, multi‐organ endotheliopathy, associated with oxidative injury to the blood–brain barrier (BBB). Preeclampsia initiates a cascade of events that include neuroinflammation. Recently, it was documented that Wnt/β‐catenin signaling pathway exerts neuroprotective effects and maintain BBB integrity. We investigate the protective effect of omega‐3 against neurovascular complication of preeclampsia and its relation to Wnt/β‐catenin signaling pathway.
A promising anode material for sodium-ion battery with high capacity and high diffusion ability: graphyne and graphdiyne

An investigation of the energetics and dynamics properties of sodium adsorption on graphyne and graphdiyne has been carried out by first-principles calculations. Graphyne (GY) and graphdiyne (GDY) is the single atomic layer structure of carbon six-member rings connected by one and two acetylenic linkages, respectively. Our calculated results indicate that a novel atomic hollow structure of graphyne and graphdiyne made up of sp- and sp2-hybridized carbon atoms reinforces not only the Na storage capacity but also the Na diffusion. For GY and GDY, the maximum sodium storage concentration is NaC4 and NaC3, respectively, far exceeding the upper limit of Na insertion into graphite to form the stage-II compound NaC12 and being also superior to the case of Li inserting into graphite to form LiC6. By only overcoming a smaller energy barrier of about 0.4 eV, Na ions can easily achieve two-dimensional diffusion on GY and GDY plane. Excellent performances of the sodium storage capacity and sodium diffusion ability make graphyne and graphdiyne promising candidates for the anode material used in sodium-ion batteries.
Transradial Approach to Cerebral Aneurysm Occlusion in a Patient with an Aberrant Right Subclavian Artery: A Case Report

Patient: Female, 60-year-old Final Diagnosis: Subarachnoid hemorrhage Symptoms: Coma Medication: — Clinical Procedure: — Specialty: Neurosurgery Objective: Rare disease Background: Retroesophageal right subclavian artery, aberrant right subclavian artery, or lusoria artery constitutes an anatomical variation with a very low prevalence in the general population. Its presence in a patient does not add difficulty for cerebral arteries catheterization when a femoral approach is used, but may make the catheterization of cerebral vessels difficult when a right transradial approach is used. Unfortunately, this type of configuration of the artery is discovered after the decision to use the type of approach. Case Report: A 60-year-old woman with a diagnosed subarachnoid hemorrhage was studied with angiography through a transradial approach. A left carotid bifurcation aneurysm was diagnosed after three-vessel angiography was performed with a Simmons type 2 catheter, making a complete loop between the right subclavian artery, aortic arc, and left carotid artery. The ruptured cerebral aneurysm was completely occluded with 8 coils. The microcatheter used for the procedure emerged from the tip of an intermediate catheter located at the union of the vertical and horizontal segment of the petrous segment of the left carotid artery. Conclusions: The presence of an aberrant right subclavian artery during cerebral angiography performed through a right transradial approach renders the treatment of a left carotid cerebral aneurysms more difficult but not impossible. Utilizing an appropriate intermediate catheter allows for stable navigation of the microcatheter and complete treatment of the aneurysm. This is the first report of cerebral aneurysm embolization through a right transra-dial approach in a patient with an aberrant right subclavian artery.
Could serum zonulin be an intestinal permeability marker in diabetes kidney disease?

Zonulin is a protein associated with the tight junction complex opening at the intestinal epithelium, previously linked to obesity, cardiovascular diseases, type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD). However, its role in CKD has not been totally elucidated. This study aimed to evaluate zonulin levels in subjects with diabetic kidney disease (DKD). This case-control study included two cases groups: 1) Advanced DKD cases: T2DM patients with estimated glomerular filtration rate (eGFR) <60ml/min/1.73m2; 2) Albuminuric T2DM cases: diabetic patients with urinary albumin excretion (UAE) >30mg/g creatinine, but with eGFR>60ml/min/1.73m2. Two control groups were also included: 1) T2DM controls: patients with T2DM without impaired kidney function; 2) Non-T2DM controls: subjects without T2DM and normal renal function. Serum levels of zonulin were measured by ELISA. Eighty-six individuals were included. Zonulin levels was different among study groups (P = 0.003). T2DM controls presented higher zonulin levels than non-T2DM controls [(131.35 (83.0–170.5) vs. 87.25 (54.7–111.8), P = 0.018] and advanced DKD cases [63.72 (45.03–106.0); P = 0.007]. Zonulin showed a positive correlation with eGFR (r = 0.222; P = 0.040), total cholesterol (r = 0.299; P = 0.034), LDL (r = 0.258; P = 0.021), and negative with albuminuria (r = -0.243; P = 0.024) and body fat (r = -0.271; P = 0.014). In the multivariate logistic regression analyses, zonulin levels were independently associated to renal outcomes [OR 0.99 (0.98–0.99, P = 0.012)] after 5-year inclusion. In conclusion, increased zonulin levels in patients with TD2M without renal disease suggest an impaired intestinal permeability. Moreover, its association with renal outcomes could indicate its use as a disease monitoring marker. However, the mechanisms behind this association should be better understood.