Miracle-dz/UniFAR-FTUs huggingface dataset:
Differences in evaluators and genetic parameter estimations using subjective measurements of beef cattle temperament

© The Author(s) 2019. Published by Oxford University Press on behalf of the American Society of Animal Science. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
Country of market effect

Purpose: This article proposes and empirically tests the country of market (COMK) effect, which captures the consumer’s responses of home market to a country where the product is marketed. Design/methodology/approach: Study 1 applies a lab experiment about Chinese consumers’ purchase intention for printers marketed either in the US or China. Study 2 applies country level data to examine the impact of economic development of 22 host countries on the performance of 167 multinational retailers in their home country. Findings: Study 1 shows that the printers marketed in US attract a higher level of purchase intention than printers marketed in China. This COMK effect is more salient for printers manufactured in China than those manufactured in US. In addition, innovation and design factors corresponding to the host country’s image fully mediate the COMK effect. Results in Study 2 show that a retailer that markets its services in a host country with a higher (lower) level of economic development is likely to generate higher (lower) level of retailing performance in its home country. Furthermore, it is found that COMK effect is diminished as the level of economic development of a vendor’s home country increases. Research limitations/implications: In addition to the cognitive components of country image (e.g., design and innovation), consumers’ affective components may also influence the COMK effect. Future research could discuss the impact of consumer ethnocentrism and consumer animosity on consumers’ attitude towards the product marketed in other countries. Practical implications: Strategically, marketing products to a country with a favorable image could benefit vendors from an emerging economy. For manufacturers from developed countries, marketing a product within their own countries may enhance the associated innovation and design images while marketing the same product in an emerging market. Originality/value: This article proposes and tests a demand side country effect on consumers’ purchase intention for products marketed in other countries. It is in sharp contrast to the traditional country effect which focuses on the supply side effect (e.g., country of origin, country of manufacture, country of assembly etc.).
Reconstruction of Three-Dimensional Blood Vessel Model Using Fractal Interpolation

Fractal method is used in the image processing and studying the irregular and the complex shapes in the image. It is also used in the reconstruction and smoothing of one-, two-, and three-dimensional data. In this chapter, we present an interpolating fractal algorithm to reconstruct 3D blood vessels. Firstly, the proposed method determines the blood vessel centerline from the 2D retina image, and then it uses the Douglas-Peucker algorithm to detect the control points. Secondly, we use the 3D fractal interpolation and iterated function systems for the visualization and reconstruction of these blood vessels. The results showed that the obtained reduction rate is between 71 and 94% depending on the tolerance value. The 3D blood vessels model can be reconstructed efficiently by using the 3D fractal interpolation method.
Transforming the Upper Mesopotamian Landscape in the Late Neolithic

The Late Neolithic period in Upper Mesopotamia is generally associated with a surge in human settlement, in terms of their number, geographic distribution, and organizational complexity. In archaeological discussion, the “advanced farming village” is often seen as the logical “end product” of the agricultural transformations that began in the Early (“Pre-Pottery”) Neolithic. However, the complex later prehistoric landscape did not emerge overnight. Current evidence suggests that this profound transformation took about one and a half millennia, and showed much localized variability. Over the past decades, regional surveys have resulted in a rich body of evidence that stimulates the exploration of long-term trends in settlement through the Neolithic period. Here we present a synthesis of this exploration. We highlight some important methodological and conceptual challenges to interpreting these data, and we point out a number of possible shifts in the ways Late Neolithic communities inhabited the landscape.
Model misspecification in approximate Bayesian computation: consequences and diagnostics

We analyse the behaviour of approximate Bayesian computation (ABC) when the model generating the simulated data differs from the actual data‐generating process, i.e. when the data simulator in ABC is misspecified. We demonstrate both theoretically and in simple, but practically relevant, examples that when the model is misspecified different versions of ABC can yield substantially different results. Our theoretical results demonstrate that even though the model is misspecified, under regularity conditions, the accept–reject ABC approach concentrates posterior mass on an appropriately defined pseudotrue parameter value. However, under model misspecification the ABC posterior does not yield credible sets with valid frequentist coverage and has non‐standard asymptotic behaviour. In addition, we examine the theoretical behaviour of the popular local regression adjustment to ABC under model misspecification and demonstrate that this approach concentrates posterior mass on a pseudotrue value that is completely different from accept–reject ABC. Using our theoretical results, we suggest two approaches to diagnose model misspecification in ABC. All theoretical results and diagnostics are illustrated in a simple running example.
The First Social Media Engagement Analysis of Health in Malaysia

Objectives: This study aimed to determine Facebook post characteristics and factors associated with good engagement rates among netizens on the Facebook (FB) page of Ministry of Health Malaysia. Methods: 2123 FB posts were randomly selected in this cross-sectional study. The logist ic regression model was applied to identify factors associated with good engagement rates. Results: Majority of the FB post characteristics were organizational promotion content, photo type and posted between midnight and early morning. An FB post with a good engagement rate was significantly associated with a health education post (Adjusted Odd Ratio (AOR): 3.80, 95% Confidence Interval CI: 3.02–4.78, p < 0.001), a risk communication post (AOR: 1.77, 95% CI: 1.39–2.26, p < 0.001), a post in the afternoon (AOR: 1.76, 95% CI: 1.34–2.31, p < 0.001) or in the evening (AOR: 1.48, 95% CI: 1.20–1.82, p < 0.001), and a video format (AOR: 3.74, 95% CI: 1.44–9.71, p = 0.007). Conclusion: We present the first comprehensive analysis of social media engagement and health communication analysis in Malaysia. The dynamic of health communication and rapid changes of health technology recently require health organizations to constantly upgrading their health promotion capacity and facilities. Therefore, they can effectively disseminate qualit y health information, achieving better audience engagement and subsequently improving health literacy among netizens on social media. International Journal of Human and Health Sciences Supplementary Issue: 2019 Page: 32
Association between Severity of Tooth Wear and Dentinal Hypersensitivity

Background & Objectives: Tooth wear (attrition, abrasion, erosion, and abfraction) is perceived globally as ever increasing problem. Several outcome of the tooth wear are hypersensitivity, esthetic problems, functional impairment, annoyance to the patient, and fracture of the tooth. Among these, the measurable and more commonly reported outcome is hypersensitivity to stimuli. Although dentin hypersensitivity is a common clinical condition and is generally reported by the patient after experiencing a sharp, short pain caused by one of the several different external stimuli, it is often inadequately understood. None of the scientific literature available till date attempted to establish the relationship between tooth wear and dentin hypersensitivity which could be a key factor in monitoring those patients. The aim of the study was to estimate the association between severity of teeth wear and sensitivity in the patients with reported dentinal hypersensitivity. Materials & Methods: Fifty patients with dentin hypersensitivity were investigated for tooth wear. Tooth wear measured using exact tooth wear index and level of sensitivity to stimuli was recorded using a numerical rating scale. Results: Enamel wear at cervical region of teeth showed a positive correlation (p=.010), similarly, dentin wear at cervical region of teeth showed positive correlation and significant association (p<.001) with dentinal hypersensitivity. Conclusion: The observation supports a significant association between severities of tooth surface wear and dentinal hypersensitivity.
Bilirubin-albumin binding capacity in term and preterm infants

Background The risk of kernicterus remains a problem in jaundiced newborn especially in low birth weight infants. Kernicterus can develop at low bilirubin levels. Bilirubin-albumin binding plays an important role in its pathogenesis. Bilirubin albumin binding concentration can also be used as the cut-off point in the administration of phototeraphy. Objective To determine the pattern of albumin binding concentration in serum model in vitro and in serum of premature and term newborn infants from cord blood sample. Methods This study was conducted in Installation of Maternal- Perinatal Dr. Sardjito Hospital from August-September 2004. Blood cord samples from 20 term and 17 preterm infants were analysed. Total bilirubin was measured spectrophotometrically and unbound bilirubin concentration was determined by horseradish peroxidase oxidation using UB-analyzer apparatus micromethod. Student t test and linear regression analysis were performed. Results Bilirubin-albumin binding capacity of term infants showed a statistically significant difference compared to that of premature infants (18.9±2.1 mg/dl vs 10.2±3.6 mg/dl, P<0.001). This cut- off level approximately reflected a value of unbound bilirubin of 1 mg/dl in term and 0.5 mg/dl in premature infants. Conclusions There is a different pattern of bilirubin-albumin binding capacity between term and preterm infants which is higher in term infants. Bilirubin level of 19 mg/dl and 10 mg/dl in term and preterm newborn, respectively, can be used as cut-off point to perform more aggressive intervention, such as phototeraphy, and to lower the risk of kernicterus.
South Korean nurses’ knowledge of delirium in hospitalised older adults with and without dementia

In South Korea, the prevalence of dementia is rapidly increasing alongside the aging of the population. The prevalence of dementia among South Korean older adults (age ≥65 years) was 8.4% in 2008, and it is expected to increase to 9.7% by 2020 and to 13.2% by 2050 [1]. The inpatient hospital costs for Alzheimer’s disease, the most common form of dementia has also been reported as being greater than for any other disease in South Korea [2]. In the first half of 2015, the total inpatient hospital spending was USD $ 388,555,222 for Alzheimer’s disease and was USD $ 6,548 per person in South Korea [2]. The rapid increase in the population of people with dementia has the potential to increase the likelihood of health care professionals in hospitals in South Korea encountering older adults with delirium superimposed on dementia (DSD) in their daily practice.
Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1

Significance Pancreatic ductal adenocarcinoma (PDA) is a highly lethal malignancy with no effective therapies. PDA aggressiveness partly stems from its ability to grow within a uniquely dense stroma restricting nutrient access. This study demonstrates that PDA clones that survive chronic nutrient deprivation acquire reversible nongenetic adaptations allowing them to switch between metabolic states optimal for growth under nutrient-replete or nutrient-deprived conditions. One contributing factor to this adaptation is mTORC1 activation, which stabilizes glutamine synthetase (GS) necessary for glutamine generation in nutrient-deprived cancer cells. Our findings imply that although total GS levels may not be a prognostic marker for aggressive disease, GS inhibition is of high therapeutic value, as it targets specific cell clusters adapted to nutrient starvation, thus mitigating tumor growth. Pancreatic ductal adenocarcinoma (PDA) is a lethal, therapy-resistant cancer that thrives in a highly desmoplastic, nutrient-deprived microenvironment. Several studies investigated the effects of depriving PDA of either glucose or glutamine alone. However, the consequences on PDA growth and metabolism of limiting both preferred nutrients have remained largely unknown. Here, we report the selection for clonal human PDA cells that survive and adapt to limiting levels of both glucose and glutamine. We find that adapted clones exhibit increased growth in vitro and enhanced tumor-forming capacity in vivo. Mechanistically, adapted clones share common transcriptional and metabolic programs, including amino acid use for de novo glutamine and nucleotide synthesis. They also display enhanced mTORC1 activity that prevents the proteasomal degradation of glutamine synthetase (GS), the rate-limiting enzyme for glutamine synthesis. This phenotype is notably reversible, with PDA cells acquiring alterations in open chromatin upon adaptation. Silencing of GS suppresses the enhanced growth of adapted cells and mitigates tumor growth. These findings identify nongenetic adaptations to nutrient deprivation in PDA and highlight GS as a dependency that could be targeted therapeutically in pancreatic cancer patients.
Clustering Short Text Messages Using Unsupervised Machine Learning

Today, large amounts of textual information can be found everywhere. If you have used digital platforms for reading books you have probably noticed there are algorithms recommending similar books you might like. Some recommendations are based on other reader’s patterns and some are based on similar content. One class of unsupervised machine learning algorithms used for semantic analysis are called topic models. These algorithms are widely used in the industry for long texts, but in the past years, there has been an increasing interest towards analyzing short texts on digital platforms, such as SMS and social media. This is due to high interest in analyzing trending topics. Doing this presents problems in data sparsity caused by the short documents. Topic models are statistical models that cluster words based on their cooccurrences in the documents. This results in word clusters which humans can interpret as topics, such as “weather” or “politics”. On top of this, each document can be given a low dimensional representation used for clustering or labeling to allow for classification of unseen text messages. In this thesis, we have chosen latent Dirichlet allocation and biterm topic model as our topic models. To infer the latent variables of these models, we used Gibbs sampling. In total, 15 unique topics are found, though more and better topics can be found with an improved model.
PREDICTION OF CORONARY ARTERY DISEASE EXTENT AND SEVERITY ON THE BASIS OF GRACE AND TIMI SCORES IN PATIENTS PRESENTED WITH

Objective: To determine the correlation of Global Registry for Acute Coronary Events (GRACE) and Thrombolysis in Myocardial Infarction (TIMI) scores with Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score (SS) to predict the extent and severity of coronary artery disease (CAD) in patients presented with first onset STE levation Myocardial Infarction (STEMI) undergoing Primary Percutaneous Coronary Intervention (PPCI). Study Design: Descriptive cross-sectional study. Place and Duration of Study: Inpatient departments of Armed Forces Institute of Cardiology/ National Institute of Heart Diseases (AFIC/NIHD), Rawalpindi, from Jan 2019 to Jun 2019. Methodology: Ethical approval was taken from Institutional Ethical Review Board (IERB), AFIC/NIHD. Patients of any age and both genders who presented with chest pain and satisfied criteria for Type 1 Myocardial Infarction (MI), as stated in 4th Universal Definition of MI, were included in study by non-probability consecutive sampling technique. Patients with a previous history of ischemic heart disease, Percutaneous Coronary Intervention (PCI) or Coronary Artery Bypass Graft (CABG) surgery were excluded. Both TIMI and GRACE scores for STEMI were calculated at time of admission. The extent and severity of CAD were assessed by the SS-I. Each coronary lesion with a diameter stenosis of at least 50%, in vessels of at least 1.5 mm, were scored. Data was analyzed using the Statistical Package for Social Sciences (SPSS) version 25. Results: Out of 376 patients, 327 (86.9%) were male and 49 (13.1%) were female. Anterior wall MI was the most common presentation 164 (43.6%). Among risk factors for CAD, hypertension was the most common one 215 (57.2%). A positive correlation was found between SS and GRACE low, intermediate and high-risk groups (0.145). Conclusion: Patients having high GRACE and TIMI scores were more likely to have severe CAD. In comparison with TIMI score, GRACE score was found to have better correlation with SS, but degree of that association was not strong enough to make it a reliable and sole predictor of CAD severity.
AVAILMENT OF FUNERAL PLANNING MANAGEMENT SERVICE AMONG CHINESE AND FILIPINO: PREPARATION OF A SERVICE DEVELOPMENT PACKAGE FOR A FUNERAL EVENT BUSINESS

The funeral industry has grown rapidly over the years. It is very evident that in the Philippines, many funeral parlors are sprouting all over the country as well funeral insurance policy companies. The funeral industry has taken more major roles in the burial rituals, funeral arrangements, body disposition procedures, last rites, and after care services to attend to the special needs. One of the richest customs in celebrating a funeral event was the Chinese society. Chinese was well known for their custom of following a lot of superstitions. Filipinos also believed in superstitions like the Chinese, but their way of celebrating the funeral rites was different. These customs make managing a funeral event difficult. That is why seeking professional guidance and support is a good idea. The study looks into the comparative study of the availment of the funeral planning management service among Chinese and Filipino to observe the difference and similarities on the level of awareness, interest, the desire and actions of the two different cultures regarding the funeral planning management service. The researcher’s purpose was to make a basis for developing an event strategy that would facilitate the acceptability of the funeral planning management service in the Philippines.
The influence of age, vitamin K and genetics on anticoagulation outcomes in adults and children

i DECLARATION OF ORIGINALITY . ii DEDICATION . iii ACKNOWLEDGEMENTS . iv TABLE OF CONTENTS . vii LIST OF TABLES . xiii LIST OF FIGURES . xv LIST OF ABBREVIATIONS . xvii PUBLICATIONS LIST . xxi CONFERENCE PRESENTATIONS . xxiii Chapter 1 General introduction . 1 Blood coagulation . 1 Thrombosis . 3 Causes and epidemiology . 3 Atrial fibrillation and risk of stroke . 4 Mechanical heart valves . 6 Prevention strategies . 7 Oral anticoagulant therapy . 7 Introduction . 7 Vitamin K antagonists . 8 History of warfarin use . 9 Mechanism of action . 9 Pharmacokinetics and pharmacodynamics . 10 Clinical indications . 12 Warfarin therapy monitoring . 12 PT/INR . 12 Time in therapeutic range . 13 Adverse effects of warfarin . 15 Bleeding . 15 Other complications . 17 Vascular calcification risk . 17 Reversal of anticoagulation due to warfarin therapy . 18 Variability in anticoagulation response . 18 Ageing . 19
Lung cancer histology-driven strategic therapeutic approaches

In the last decades, the dichotomic distinction between small cell (SCLC) and non-small cell lung cancer (NSCLC) has been one of the key parameters in the therapeutic management of lung cancer. However, the advent of targeted therapies based on druggable oncogenic molecular alterations and immunotherapy interfering with the PD1/PD-L1 checkpoint has overridden the role of the precise definition of tumour histologic type in the modern approach to lung cancer, particularly in NSCLC. While a better definition of histotype in NSCLC may be still helpful in selecting chemotherapy regimens in those NSCLC lacking targetable genetic alterations (i.e., EGFR and BRAF mutations, ALK and ROS1 rearrangements) and PD-L1 overexpression, the possible identification of targetable oncogenic drivers in liquid biopsy using high throughput deep sequencing methods will somehow change the paradigm of histology determination as one the mandatory step in future therapeutic strategies in lung cancer. Thus, in this review we challenge the future role of histotype as an important influencing factor in the clinical management of patients with
The complete chloroplast genome of Grateloupia turuturu Yamada

Abstract In this study, we sequenced and annotated the complete chloroplast genome of Grateloupia turuturu Yamada (GenBank accession number: MN853877). The total length of the chloroplast genome is 188,547 bps, including 196 protein-encoding genes, 23 tRNA genes and 3 rRNA. The complete chloroplast genome of G. turuturu is 30.68% C + G, which is lower than that of A + T. The phylogenetic tree, which is based on core genes, shows that G. turuturu is clustered into the Grateloupia clade and has close genetic relationships with algae Grateloupia filicina and Grateloupia taiwanensis. These data will provide more information to understand the phylogenetic status of G. turuturu.
Effect of Low Temperature on Chlorophyll and Carotenoid Content on the Seedlings of Some Selected Boro Rice Varieties

A study was conducted to screen out the low-temperature tolerant Boro rice seedlings from November 2012 to January 2013 for facing the upcoming rice production challenge in Northwest Bangladesh. The experimental time was characterized by a prevailing low environmental temperature of below 15°C. Five rice cultivars (V1: BR-2; V2: BR-16; V3: Pariza; V4: Minicate; V5: BRRI dhan 50) were selected for the study. The leaf proline, chlorophyll content and total carotenoid content were investigated. The V2 (BR-16) seedling synthesized the higher leaf proline (1.228 g·g-1) at a low temperature than those of other tested cultivars. Again, the highest amount of chlorophyll-a (3.957 g·g-1), chlorophyll-b (2.118 g·g-1), chlorophyll-a/b ratio (3.6754 mg·g-1) and total chlorophyll (5.051 g·g-1) was measured in V2 (BR-16). The maximum total carotenoid (1.213 g·g-1) was also observed in V2. In this experiment, the V2 (BR-16) showed comparatively better potentiality to survive at low temperatures (below 15°C) than other varieties.