Miracle-dz/UniFAR-FTUs huggingface dataset:
Vietnamiella epiphytica – a new genus and species of Anastrophyllaceae (Hepaticae)

Abstract. Vietnamiella epiphytica gen. et sp. nov. is described based on the results of integrative research including morphological, ecological, phytogeographical and molecular-genetic studies. Superficially the new taxon is similar to some taxa of Andrewsianthus from which, however, it differs in a number of features including ventral intercalary branching, versus dorsal intercalary branches that commonly change into positively geotropic stolons in Andrewsianthus. Moreover, the closest relative of Vietnamiella, placed in Anastrophyllaceae, was found to be Hattoria, which is strikingly different from Vietnamiella, especially in its entire and cup-shaped leaves. The morphological description, figures and differentiations are provided for Vietnamiella.
Leucine Rich Repeat Kinase 2 and Innate Immunity

For more than a decade, researchers have sought to uncover the biological function of the enigmatic leucine rich repeat kinase 2 (LRRK2) enzyme, a large multi-domain protein with dual GTPase and kinase activities. Originally identified as a familial Parkinson’s disease (PD) risk gene, variations in LRRK2 are also associated with risk of idiopathic PD, inflammatory bowel disease and susceptibility to bacterial infections. LRRK2 is highly expressed in peripheral immune cells and the potential of LRRK2 to regulate immune and inflammatory pathways has emerged as common link across LRRK2-implicated diseases. This review outlines the current genetic and biochemical evidence linking LRRK2 to the regulation of innate immune inflammatory pathways, including the toll-like receptor and inflammasome pathways. Evidence suggests a complex interplay between genetic risk and protective alleles acts to modulate immune outcomes in a manner dependent on the particular pathogen and cell type invaded.
Early-Stage Progression of Breast Cancer

Breast cancer can be defined as a group of diseases with heterogeneous origins, molecu - lar profiles and behaviors characterized by uncontrolled proliferation of cells within the mammary tissue. Around one in eight women in the US will develop breast cancer in their lifetime, making it the second most frequently diagnosed cancer behind skin cancer [1 ]. In 2015, an estimated 231,840 cases of invasive carcinoma were diagnosed, and over 40,000 deaths were caused by breast cancer which accounts for almost 7% of all cancer mortality each year [ 1 , 2]. In 2015, 60,290 cases of in situ breast cancer were diagnosed, rep - resenting over 14% of all new cancer cases among women and men [ 1 ]. The steep increase in diagnosis of early‐stage breast cancer over the past 10 years is believed to be a result of more frequent mammography. However, since over half of these in situ lesions will not progress to invasive breast cancer, controversies have arisen about approaches to treat - ment and prevention of progression of early‐stage in situ breast cancer. Understanding the mechanisms of transition of normal breast to in situ pre‐neoplastic lesions and inva - sive breast cancer is currently a major focus of breast cancer research with implications for preventive and clinical management of breast cancer. In this review, we give an over - view of current knowledge on the molecular and pathological changes that occur during early‐stage progression of breast cancer and describe some of the current models that are used to study this process.
miR-335 Acts as a Tumor Suppressor and Enhances Ionizing Radiation-Induced Tumor Regression by Targeting ROCK1

Recent development of integrative therapy against melanoma combines surgery, radiotherapy, targeted therapy, and immunotherapy; however, the clinical outcomes of advanced stage and recurrent melanoma are poor. As a skin cancer, melanoma is generally resistant to radiotherapy. Hence, there is an urgent need for evaluation of the mechanisms of radioresistance. The present study identified miR-335 as one of the differential expression of miRNAs in recurrent melanoma biopsies post-radiotherapy. The expression of miR-335 declined in melanoma tissues compared to the adjacent tissues. Moreover, miR-335 expression correlated with advanced stages of melanoma negatively. Consistent with the prediction of STARBASE and miRDB database, miR-335 targeted ROCK1 via binding with 3′-UTR of ROCK1 directly, resulting in attenuation of proliferation, migration, and radioresistance of melanoma cells. The authors validated that overexpression of miR-335 enhanced X-ray-induced tumor regression by B16 mouse models. Briefly, the present findings gained insights into miR-335/ROCK1-mediated radiosensitivity and provided a promising therapeutic strategy for improving radiotherapy against melanoma.
Enhancing direct citations: A comparison of relatedness measures for community detection in a large set of PubMed publications

The effects of enhancing direct citations, with respect to publication–publication relatedness measurement, by indirect citation relations (bibliographic coupling, cocitation, and extended direct citations) and text relations on clustering solution accuracy are analyzed. For comparison, we include each approach that is involved in the enhancement of direct citations. In total, we investigate the relative performance of seven approaches. To evaluate the approaches we use a methodology proposed by earlier research. However, the evaluation criterion used is based on MeSH, one of the most sophisticated publication-level classification schemes available. We also introduce an approach, based on interpolated accuracy values, by which overall relative clustering solution accuracy can be studied. The results show that the cocitation approach has the worst performance, and that the direct citations approach is outperformed by the other five investigated approaches. The extended direct citations approach has the best performance, followed by an approach in which direct citations are enhanced by the BM25 textual relatedness measure. An approach that combines direct citations with bibliographic coupling and cocitation performs slightly better than the bibliographic coupling approach, which in turn has a better performance than the BM25 approach.
Spatial Structure of Marine Host-Associated Microbiomes: Effect of Taxonomy, Species Traits, and Study Design

Marine host-associated microbiomes can strongly influence their host’s function and are shaped by selection, dispersal, diversification, and drift. These processes can lead to spatially structured microbiomes, with potential implications for host fitness in different locations. We review the literature on marine host-associated microbiomes to identify if spatially structured microbiomes are more prevalent in certain taxonomic groups, are linked to species traits, or sampling design and methodology. The 28 papers analyzed represented 38 host species, with spatial structure detected in 75% of species, increasing to 83% when restricted to studies using high-throughput DNA sequencing. Spatial structure was detected in all coral and marine mammal microbiomes, but was less common in fish (69%) and sponges (46%). Mobile species and external tissues were more likely to show spatially structured microbiomes than sessile species and internal tissues. We found no relationship between spatial structuring and maximum distance between sampling sites, with studies on large (>1000 km) and small spatial scales (<100 km) almost as likely to show spatial structure (87% vs. 79%). Our results support using high-throughput sequencing for studying marine host-associated microbiomes due to better taxonomic resolution compared to other methods. Given the observed generality of spatially structured microbiomes, future studies should test whether microbiome variation between locations affects host fitness. Researchers should include sufficient environmental microbiome sampling and host data to distinguish host and environmental effects. This will help resolve the relative importance of selection, dispersal, diversification and drift in shaping marine host-associated microbiomes.
ACCUMULATION OF HYDROGEN RELEASED INTO A VENTED ENCLOSURE-EXPERIMENTAL RESULTS

This paper reports experimental results from a series of experiments in which gaseous hydrogen was released into a 31 m3 enclosure and the hydrogen concentrations at a number of points within the enclosure were monitored to assess whether hydrogen accumulation occurred and whether a homogeneous or stratified mixture was formed. The enclosure was located in the open air and therefore subject to realistic, and therefore variable, wind conditions. The hydrogen release rate and the passive vent arrangements were varied. The experiments were carried out as part of the EU Hyindoor Project. 1.0 INTRODUCTION Hydrogen energy applications often require that systems be used indoors or in enclosures (e.g. fork lift trucks in a warehouse, fuel cells located in a room, or hydrogen stored and distributed from a gas cabinet). The release of hydrogen in such facilities can potentially lead to its accumulation, the formation of a flammable hydrogen-air mixture and subsequent ignition. Existing knowledge gaps in the behaviour of indoor hydrogen releases are to be addressed as part of the three year HyIndoor project. This paper reports the initial results from an experimental programme to investigate the accumulation and dispersion behaviour of hydrogen released within an enclosure fitted with passive ventilation. The objective of the experiments at HSL is to provide concentration data that can be used by HSL and other Hyindoor partners to test the validity of predictive mathematical models and simple engineering tools. In particular, the experiments are to investigate; the influence of the wind on the dispersion regimes (mixing versus displacement regime), where the wind would have a negative impact and how this could be mitigated, and how the dispersion/accumulation behaviour of choked flow hydrogen releases differs from that arising from sub-sonic releases of equivalent mass flow-rate. 2.0 EXPERIMENTAL ARRANGEMENT 2.1 Enclosure and hydrogen release system The experimental set-up consists of a 31 m enclosure with cross sectional area of 2.5 m by 2.5 m and a length of 5 m. Five similar vents (0,83 m width and 0,27 m height) are located on the sides of the enclosure and a circular vent of same area is located on the roof; these can be closed or opened as required. The enclosure can withstand an internal over-pressure of at least 0.2 bar and is fitted with explosion relief panels in the roof in case of accidental ignition of the hydrogen air mixtures.
Prevention of thrombus formation following transcatheter aortic valve replacement in patients with durable left ventricular assist device

To the Editor, Aortic insufficiency is one of the unsolved critical comorbidities during durable left ventricular assist device (LVAD) support. Transcatheter aortic valve replacement (TAVR) is a recently developed procedure to treat aortic insufficiency in LVAD patients, although its long-term efficacy and safety remain uninvestigated. Rao et al reported the TAVRassociated thrombosis in a patient with LVAD. Although preventive and therapeutic strategy for the TAVR-associated thrombosis remains unknown, there are several proposals. The authors could not intensify anticoagulation therapy to treat thrombus, given repeated gastrointestinal bleedings. For the prevention of bleedings, it might be recommended to use recently proposed omega-3 fatty acid and/or digoxin, which would allow relatively aggressive anticoagulation therapy. Second, as the authors mention, an effort to open native aortic valve might be another strategy to prevent thrombus formation. In addition to maintaining relatively lower device speed, aggressive uptitration of antiheart failure medications might promote left ventricular reverse remodeling and increase cardiac systolic function to open native aortic valve. Exercise opens native aortic valve in some LVAD patients. Daily exercise via aggressive cardiac rehabilitation program might open native aortic valve intermittently and prevent thrombus formation.
Adenosine‐5′‐triphosphate suppresses proliferation and migration capacity of human endometrial stem cells

Extracellular ATP through the activation of the P2X and P2Y purinergic receptors affects the migration, proliferation and differentiation of many types of cells, including stem cells. High plasticity, low immunogenicity and immunomodulation ability of mesenchymal stem cells derived from human endometrium (eMSCs) allow them to be considered a prominent tool for regenerative medicine. Here, we examined the role of ATP in the proliferation and migration of human eMSCs. Using a wound healing assay, we showed that ATP‐induced activation of purinergic receptors suppressed the migration ability of eMSCs. We found the expression of one of the ATP receptors, the P2X7 receptor in eMSCs. In spite of this, cell activation with specific P2X7 receptor agonist, BzATP did not significantly affect the cell migration. The allosteric P2X7 receptor inhibitor, AZ10606120 also did not prevent ATP‐induced inhibition of cell migration, confirming that inhibition occurs without P2X7 receptor involvement. Flow cytometry analysis showed that high concentrations of ATP did not have a cytotoxic effect on eMSCs. At the same time, ATP induced the cell cycle arrest, suppressed the proliferative and migration capacity of eMSCs and therefore could affect the regenerative potential of these cells.
Comparative Root Transcriptomics Provide Insights into Drought Adaptation Strategies in Chickpea (Cicer arietinum L.)

Drought adversely affects crop production across the globe. The root system immensely contributes to water management and the adaptability of plants to drought stress. In this study, drought-induced phenotypic and transcriptomic responses of two contrasting chickpea (Cicer arietinum L.) genotypes were compared at the vegetative, reproductive transition, and reproductive stages. At the vegetative stage, drought-tolerant genotype maintained higher root biomass, length, and surface area under drought stress as compared to sensitive genotype. However, at the reproductive stage, root length and surface area of tolerant genotype was lower but displayed higher root diameter than sensitive genotype. The shoot biomass of tolerant genotype was overall higher than the sensitive genotype under drought stress. RNA-seq analysis identified genotype- and developmental-stage specific differentially expressed genes (DEGs) in response to drought stress. At the vegetative stage, a total of 2161 and 1873 DEGs, and at reproductive stage 4109 and 3772 DEGs, were identified in the tolerant and sensitive genotypes, respectively. Gene ontology (GO) analysis revealed enrichment of biological categories related to cellular process, metabolic process, response to stimulus, response to abiotic stress, and response to hormones. Interestingly, the expression of stress-responsive transcription factors, kinases, ROS signaling and scavenging, transporters, root nodulation, and oxylipin biosynthesis genes were robustly upregulated in the tolerant genotype, possibly contributing to drought adaptation. Furthermore, activation/repression of hormone signaling and biosynthesis genes was observed. Overall, this study sheds new insights on drought tolerance mechanisms operating in roots with broader implications for chickpea improvement.
Sulfur dioxide induces vascular relaxation through PI3K/Akt/eNOS and NO/cGMP signaling pathways in rats

Sulfur dioxide (SO2) is a common exogenous atmospheric pollutant. Studies have shown that SO2 can cause vasodilation as a gas signaling molecule, but the specific signaling pathways are not well understood. This study aimed to explore the underlying mechanism behind the effects of SO2 on vasodilation of isolated rat aorta. The results showed that when the dose of SO2 was 30 μM, the vasodilation of endothelium-intact rings was partially suppressed by LY294002 and NG-nitro-l-arginine methyl ester, and the protein levels of phosphoinositide 3-kinase (PI3K), p-Akt, and p-endothelial nitric oxide synthase (p-eNOS) were significantly increased. When the dose of SO2 was 300 μM or 1500 μM, the vasodilation of endothelium-denuded rings did not change after application of the inhibitor, but the protein levels of PI3K, p-Akt, and p-eNOS were significantly decreased, and the activity of NOS and the level of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) were significantly increased. We speculate that the mechanism of SO2-induced vasodilatation likely involved the endothelial PI3K/Akt/eNOS and NO/cGMP signal pathways. In addition, at the concentration of 1500 μM, SO2 markedly increased the level of caspase-3 and caspase-9. The results suggest that high concentrations of SO2 may cause damage to blood vessels. This study will help to further inform the etiologies of SO2-related cardiovascular disease.
Effects of hypoxia on the behavior and physiology of kelp forest fishes

Forecasts from climate models and oceanographic observations indicate increasing deoxygenation in the global oceans and an elevated frequency and intensity of hypoxic events in the coastal zone, which have the potential to affect marine biodiversity and fisheries. Exposure to low dissolved oxygen (DO) conditions may have deleterious effects on early life stages in fishes. This study aims to identify thresholds to hypoxia while testing behavioral and physiological responses of two congeneric species of kelp forest fish to four DO levels, ranging from normoxic to hypoxic (8.7, 6.0, 4.1, and 2.2 mg O2/L). Behavioral tests identified changes in exploratory behavior and turning bias (lateralization), whereas physiological tests focused on determining changes in hypoxia tolerance (pCrit), ventilation rates, and metabolic rates, with impacts on the resulting capacity for aerobic activity. Our findings indicated that copper rockfish (Sebastes caurinus) and blue rockfish (Sebastes mystinus) express sensitivity to hypoxia; however, the strength of the response differed between species. Copper rockfish exhibited reduced absolute lateralization and increased escape time at the lowest DO levels, whereas behavioral metrics for blue rockfish did not vary with oxygen level. Both species exhibited decreases in aerobic scope (as a function of reduced maximum metabolic rate) and increases in ventilation rates to compensate for decreasing oxygen levels. Blue rockfish had a lower pCrit and stronger acclimation response compared to copper rockfish. The differences expressed by each species suggest that acclimatization to changing ocean conditions may vary, even among related species that recruit to the same kelp forest habitat, leading to winners and losers under future ocean conditions. Exposure to hypoxia can decrease individual physiological fitness through metabolic and aerobic depression and changes to anti‐predator behavior, with implications for the outcome of ecological interactions and the management of fish stocks in the face of climate change.
Development and evaluation of the red flag campaign for the primary prevention of sexual and dating violence on college campuses

Abstract Objective Sexual and dating violence (SV/DV) on college campuses is a pervasive problem with far-reaching implications for public health. This paper describes the development and evaluation of a widely disseminated SV/DV primary prevention program, the Red Flag Campaign (RFC). Participants and Methods: An online survey was administered to 203 freshmen at a southeastern US university, of whom 82% reported exposure to the RFC in the previous month. Results: College students exposed to the RFC reported greater efficacy for intervening as a bystander compared to those students who were not exposed. These results held when looking at exposure to RFC messages specifically, but not RFC events. Conclusions: This evaluation offers preliminary evidence that the RFC is effective at increasing determinants of prosocial bystander behavior, the enactment of which could reduce SV/DV on college campuses. Implications and recommendations for college personnel implementing the RFC are discussed.
Plasma Short‐Chain Fatty Acids in Patients With Parkinson's Disease

Short‐chain fatty acids are exclusively produced by gut microbiota and are reduced in feces of patients with Parkinson's disease (PD). The objective of this study was to conduct a case–control study on peripheral concentration of short‐chain fatty acids based on evidence of pathologic changes in the blood–brain barrier in PD and the possible role of short‐chain fatty acids in blood–brain barrier permeability.
Associations between self‐reported physical activity, quality of life, and emotional well‐being in men with prostate cancer on active surveillance

The relationship between physical activity (PA) and quality of life (QOL) relative to active treatment for prostate cancer (PCa) has been well‐studied; however, little is known about this relationship during active surveillance (AS). Moreover, whether PA is associated with better emotional well‐being (EWB) in men with low‐risk PCa requires further investigation. Accordingly, we examined the association between self‐reported PA and the average change in QOL and EWB over time during AS.
Association between Soft Drink Consumption and Aggressive Behaviour among a Quarter Million Adolescents from 64 Countries Based on the Global School-Based Student Health Survey (GSHS)

Soft drink consumption has become a significant public health concern that is associated with various adverse health outcomes. We aim to examine the association between soft drink consumption and aggressive behavior among adolescents. We used open access data from 79 studies in 64 countries, including 263,890 adolescents aged 12–18 years who completed the global school-based student health survey (GSHS). Self-reported data on past 30-day carbonated soft drink consumption (number of times per day) and past 12-month physical fighting were utilized for analysis. Of the 263,890 participants (48% boys) aged 12–18 years, the weighted mean frequency of soft drink consumption varied from 0.5 in Kiribati to 2.5 times/day in Surname, while the weighted prevalence of frequent aggressive behavior varied from to 2.7% in Laos to 49.2% in Tuvalu. We found that each increment of soft drink consumption (time/day) was associated with an 11% (95%CI 10–13%) increase of the likelihood of frequent physical fighting. This result remained significant after adjusting for various covariates. In this large pooled sample of multinational data, there is a significant positive association between soft drink consumption and aggressive behavior among adolescents. Reducing soft drink consumption may help reduce aggressive behavior, a major risk factor for violence.