Miracle-dz/UniFAR-FTUs huggingface dataset:
Walking the Talk: LGBTQ Allies in Australian Secondary Schools

Sexual culture(s) are an active presence in the shaping of school relations, and LGBTQ issues have long been recognized as a dangerous form of knowledge in school settings. Queer issues in educational domains quickly attract surveillance and have historically often been aggressively prosecuted and silence enforced. This paper examines the intersections of straight allies in promoting an LGBTQ visibility and agency in Australian secondary schools. Drawing on interviews with “straight”-identified secondary students, a narrative methodology was utilized to explore the presence of student allies for making safe schools. Drawing on straight secondary students' responses to LGBTQ issues in their schools, firsthand accounts of intervening in heteronorming school cultures focus on experiences of being an ally to address LGBTQ inclusivity in Australian secondary schools.
Early Predictors of the Increase in Perihematomal Edema Volume After Intracerebral Hemorrhage: A Retrospective Analysis From the Risa-MIS-ICH Study

Background and Purpose: Perihematomal edema (PHE) is associated with poor functional outcomes after intracerebral hemorrhage (ICH). Early identification of risk factors associated with PHE growth may allow for targeted therapeutic interventions. Methods: We used data contained in the risk stratification and minimally invasive surgery in acute intracerebral hemorrhage (Risa-MIS-ICH) patients: a prospective multicenter cohort study. Patients' clinical, laboratory, and radiological data within 24 h of admission were obtained from their medical records. The absolute increase in PHE volume from baseline to day 3 was defined as iPHE volume. Poor outcome was defined as modified Rankin Scale (mRS) of 4 to 6 at 90 days. Binary logistic regression was used to assess the relationship between iPHE volume and poor outcome. The receiver operating characteristic curve was used to find the best cutoff. Linear regression was used to identify variables associated with iPHE volume (ClinicalTrials.gov Identifier: NCT03862729). Results: One hundred ninety-seven patients were included in this study. iPHE volume was significantly associated with poor outcome [P = 0.003, odds ratio (OR) 1.049, 95% confidence interval (CI) 1.016–1.082] after adjustment for hematoma volume. The best cutoff point of iPHE volume was 7.98 mL with a specificity of 71.4% and a sensitivity of 47.5%. Diabetes mellitus (P = 0.043, β = 7.66 95% CI 0.26–15.07), black hole sign (P = 0.002, β = 18.93 95% CI 6.84–31.02), and initial ICH volume (P = 0.018, β = 0.20 95% CI 0.03–0.37) were significantly associated with iPHE volume. After adjusting for hematoma expansion, the black hole sign could still independently predict the increase of PHE (P < 0.001, β = 21.62 95% CI 10.10–33.15). Conclusions: An increase of PHE volume >7.98 mL from baseline to day 3 may lead to poor outcome. Patients with diabetes mellitus, black hole sign, and large initial hematoma volume result in more PHE growth, which should garner attention in the treatment.
Optical Stimulation Luminescence Dating of Deltas Revealed the Early to Mid-Holocene Lake-level Fluctuations of Daihai, Inner Mongolia, Northern China

Lake-level reconstruction of inland enclosed lakes especially for monsoon-sensitive areas is of great significance to reveal regional climate changes. Daihai, a typical enclosed lake at the marginal of the East Asian summer monsoon (EASM) area in north China, is sensitive to climate changes due to its unique regional characteristics. There were a series of lakeshore terraces, highstand lacustrine sediments, and braided river deltas, providing sufficient geomorphologic and stratigraphic evidence for the reconstruction of lake-level fluctuations of Daihai. Reconstructed lake-level variations during the early and mid-Holocene were constructed based on 22 quartz optical stimulated luminescence (OSL) ages from six well-preserved profiles around Daihai Basin. Our results indicated Daihai showed a relatively low level at 10.2 ka, and a gradually increasing lake level following the enhanced monsoon precipitation during the mid-Holocene. Specifically, the high lake level began to develop at 8.1 ka and reached the maximum at 5.2 ka, with ∼40 m higher than present. At this time, the lake area expanded to ∼400 km2, approximately six times as large as that of present, corresponding to the maximum monsoon precipitation and intensity of EASM during the mid-Holocene. However, our stratigraphic records showed a part of the depositional records in the north and east of the Daihai was missed after 5.2 ka, probably indicating a sudden drop of the Daihai lake level. These rapid level fluctuations were likely to be interpreted by some local scenarios and need to be further investigated in the future. Overall, the lake-level fluctuation of Daihai during the early and mid-Holocene was slightly different from that observed in the previously published regional records. Possibly, the interaction of the EASM and regional feedback from topography, and hydrology factors might have contributed to the spatial complexity and distinction.
SIRT1/PGC-1α/PPAR-γ Correlate With Hypoxia-Induced Chemoresistance in Non-Small Cell Lung Cancer

Resistance is the major cause of treatment failure and disease progression in non-small cell lung cancer (NSCLC). There is evidence that hypoxia is a key microenvironmental stress associated with resistance to cisplatin, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), and immunotherapy in solid NSCLCs. Numerous studies have contributed to delineating the mechanisms underlying drug resistance in NSCLC; nevertheless, the mechanisms involved in the resistance associated with hypoxia-induced molecular metabolic adaptations in the microenvironment of NSCLC remain unclear. Studies have highlighted the importance of posttranslational regulation of molecular mediators in the control of mitochondrial function in response to hypoxia-induced metabolic adaptations. Hypoxia can upregulate the expression of sirtuin 1 (SIRT1) in a hypoxia-inducible factor (HIF)-dependent manner. SIRT1 is a stress-dependent metabolic sensor that can deacetylate some key transcriptional factors in both metabolism dependent and independent metabolic pathways such as HIF-1α, peroxisome proliferator-activated receptor gamma (PPAR-γ), and PPAR-gamma coactivator 1-alpha (PGC-1α) to affect mitochondrial function and biogenesis, which has a role in hypoxia-induced chemoresistance in NSCLC. Moreover, SIRT1 and HIF-1α can regulate both innate and adaptive immune responses through metabolism-dependent and -independent ways. The objective of this review is to delineate a possible SIRT1/PGC-1α/PPAR-γ signaling-related molecular metabolic mechanism underlying hypoxia-induced chemotherapy resistance in the NSCLC microenvironment. Targeting hypoxia-related metabolic adaptation may be an attractive therapeutic strategy for overcoming chemoresistance in NSCLC.
Identification of a Four Hypoxia-Associated Long Non-Coding RNA Signature and Establishment of a Nomogram Predicting Prognosis of Clear Cell Renal Cell Carcinoma

To identify novel hypoxia-associated long non-coding RNAs (lncRNAs) as potential biomarkers, we developed a risk stratification signature and constructed a prognosis prediction nomogram of clear cell renal cell carcinoma (ccRCC). Hypoxia-related lncRNAs were identified through Pearson correlation analysis between the expression profiles of hypoxia-related differentially expressed genes and lncRNAs from The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma (TCGA-KIRC) dataset. Then, a signature of four key lncRNAs (COMETT, EMX2OS, AC026462.3, and HAGLR) was developed. The four lncRNAs were downregulated in high-grade, advanced stage, and high-risk ccRCC. The signature had an independent and long-standing prognosis prediction ability up to a 10-year follow-up. Notably, the risk score was significantly positively correlated with the infiltration abundances of six immune cells from the Tumor IMmune Estimation Resource (TIMER). The gene set enrichment analysis (GSEA) also suggested that the signature was involved in metabolism and tumorigenesis, which were closely related to the hypoxic tumor microenvironment. Ultimately, a nomogram of signature, age, stage, and grade, was built to predict the individual long-term survival possibility. Finally, the expressions of four lncRNAs were validated by quantitative real-time PCR (qRT-PCR). Our study identified a four-lncRNA signature and established a prognostic nomogram that reliably predicts survival in ccRCC. The findings may be beneficial to therapeutic customization and medical decision-making.
Aortic Valve Sclerosis in High-Risk Coronary Artery Disease Patients

Background: Current knowledge regarding the relationship between aortic valve sclerosis (AVSc), cardiovascular risk factors, and mortality in patients with known coronary artery disease (CAD) is still unclear. The present study aimed at investigating the prevalence of AVSc as well as its association with long-term all-cause mortality in high-risk CAD patients that has never been explored in large cohorts thus far. Methods and Results: In this retrospective and observational cohort study we enrolled high-risk CAD patients, hospitalized at Centro Cardiologico Monzino (CCM), Milan, Italy, between January 2006 and December 2016. The morphology and function of the aortic valve were assessed from the recorded echocardiographic images to evaluate the presence of AVSc, defined as a non-uniform thickening of the aortic leaflets with no consequences on hemodynamics. Data on 5-year all-cause mortality was retrieved from a Regional database. Of the 5,489 patients initially screened, 4,938 (mean age 67 ± 11 years, 3,954 [80%] men) were enrolled in the study. In the overall population, AVSc was detected in 2,138 (43%) patients. Multivariable LASSO regression revealed that age, female gender, diabetes mellitus, previous MI, and left ventricular ejection fraction were independently associated with AVSc. All-cause mortality (adjusted hazard ratio: 1.29, 95%CI: 1.05–1.58) was significantly higher in AVSc than in non-AVSc patients. Conclusions: AVSc is frequently detected in high-risk CAD patients and is associated with long-term mortality. Our findings corroborate the hypothesis that AVSc is an underestimated marker of systemic cardiovascular risk. Thus, AVSc detection may be used to improve long-term risk stratification of high-risk CAD patients.
Comparing the Effectiveness of Endoscopic Surgeries With Intensity-Modulated Radiotherapy for Recurrent rT3 and rT4 Nasopharyngeal Carcinoma: A Meta-Analysis

Background This meta-analysis aimed to compare the efficacy of intensity-modulated radiotherapy (IMRT) and endoscopic surgery (ES) for high T-stage recurrent nasopharyngeal carcinoma (NPC). Methods Relevant studies were retrieved in six databases from 02/28,2011 to 02/28,2021. The 2-year, 3-year, 5-year overall survival (OS) rates and 2-year disease-free survival (DFS) rates were calculated to compare the survival outcomes of the two treatments of IMRT and ES. Combined odds ratios (ORs) and 95% confidence interval (C Is) were measured as effect size on the association between high T-stage and 5-year OS rates. Results A total of 23 publications involving 2,578 patients with recurrent NPC were included in this study. Of these, 1611 patients with recurrent rT3-4 NPC were treated with ES and IMRT in 358 and 1,253 patients, respectively. The combined 2-year OS and 5-year OS rates for the two treatments were summarized separately, and the 2-year OS and 5-year OS rate for ES were 64% and 52%, respectively. The 2-year OS and 5-year OS rate for IMRT were 65% and 31%, respectively. The combined 2-year DFS rates of IMRT and ES were 60% and 50%, respectively. Combined ORs and 95% confidence intervals for 5-year survival suggest that ES may improve survival in recurrent NPC with rT3-4. In terms of complications, ES in the treatment of high T-stage recurrent NPC is potentially associated with fewer complications. Conclusions The results of our study suggest that ES for rT3-4 may be a better treatment than IMRT, but the conclusion still needs to be sought by designing more studies.
A Comparative Study on Low and High Salinity Tolerance of Two Strains of Pinctada fucata

This study compares salinity tolerance between red and black shell Pinctada fucata salinity stress of 20 and 50‰, while 35‰ was used as a control. The hemolymph osmotic pressure, inorganic ion concentration, the activities of Na+-K+ -ATPase, respiratory metabolism related enzymes and liver tissue antioxidant related enzymes were measured at 12 and 24 h after salinity stress. The osmotic pressure and inorganic ion concentration of hemolymph of two strains P. fucata increased significantly with the increase of salinity. The activity of Na+-K+ -ATPase of red P. fucata only decreased under low salinity at 24 h, and was significantly higher than that the control under low salinity at 12 h and high salinity at 12 and 24 h. The succinate dehydrogenase (SDH) activities of the P. fucata treatment groups were significantly higher than those the control at 12 h. The lactate dehydrogenase (LDH) activity increased significantly with salinity at 12 h. and the black P. fucata LDH activity was significantly higher than the control at 24 h, while the LDH activity of red P. fucata was significantly lower than that the control in 50‰ salinity. The superoxide dismutase (SOD) activity of black P. fucata was significantly lower than that the control, while that of red P. fucata was significantly higher than that the control within 24. At 12 h, the catalase (CAT) activity of red P. fucata increased significantly with salinity, but decreased significantly with salinity at 24 h. The CAT activity of black P. fucata was highest at 24 h under low salinity. Glutathione peroxidase (GSH-Px) and alkaline phosphatase (AKP) activities of red P. fucata were significantly higher than those the control under low or high salinity. At high salinity for 24 h, the GSH-Px activity was lowest in black P. fucata, AKP activity was highest. The present study indicates that the physical responses of P. fucata to the salinity stress vary with shell colors. The red P. fucata can quickly respond positively to the change of environmental salinity and reduce the damage caused by the change of environmental salinity.
Genome-Wide Analyses Reveal the Genetic Architecture and Candidate Genes of Indicine, Taurine, Synthetic Crossbreds, and Locally Adapted Cattle in Brazil

Cattle population history, breeding systems, and geographic subdivision may be reflected in runs of homozygosity (ROH), effective population size (Ne), and linkage disequilibrium (LD) patterns. Thus, the assessment of this information has become essential to the implementation of genomic selection on purebred and crossbred cattle breeding programs. In this way, we assessed the genotype of 19 cattle breeds raised in Brazil belonging to taurine, indicine, synthetic crossbreds, and Iberian-derived locally adapted ancestries to evaluate the overall LD decay patterns, Ne, ROH, and breed composition. We were able to obtain a general overview of the genomic architecture of cattle breeds currently raised in Brazil and other tropical countries. We found that, among the evaluated breeds, different marker densities should be used to improve the genomic prediction accuracy and power of genome-wide association studies. Breeds showing low Ne values indicate a recent inbreeding, also reflected by the occurrence of longer ROH, which demand special attention in the matting schemes to avoid extensive inbreeding. Candidate genes (e.g., ABCA7, PENK, SPP1, IFNAR1, IFNAR2, SPEF2, PRLR, LRRTM1, and LRRTM4) located in the identified ROH islands were evaluated, highlighting biological processes involved with milk production, behavior, rusticity, and fertility. Furthermore, we were successful in obtaining the breed composition regarding the taurine and indicine composition using single-nucleotide polymorphism (SNP) data. Our results were able to observe in detail the genomic backgrounds that are present in each breed and allowed to better understand the various contributions of ancestor breeds to the modern breed composition to the Brazilian cattle.
Genetic Diversity and Population Structure of Vibrio parahaemolyticus Isolated From Clinical and Food Sources

Vibrio parahaemolyticus is a common foodborne pathogen that causes gastroenteritis worldwide. Determining its prevalence and genetic diversity will minimize the risk of infection and the associated economic burden. Multilocus sequence typing (MLST) is an important tool for molecular epidemiology and population genetic studies of bacteria. Here, we analyzed the genetic and evolutionary relationships of 162 V. parahaemolyticus strains isolated in the Guangdong Province, China, using MLST. In the study, 120 strains were isolated from food samples, and 42 strains were isolated from clinical samples. All strains were categorized into 100 sequence types (STs), of which 58 were novel (48 from the food isolates and 10 from the clinical isolates). ST415 was the most prevalent ST among the food isolates, while ST3 was the most prevalent ST among the clinical isolates. Further, 12 clonal complexes, 14 doublets, and 73 singletons were identified in all ST clusters, indicating high genetic diversity of the analyzed strains. At the concatenated sequence level, non-synonymous sites in both, food and clinical isolates, were associated with purifying selection. Of note, the dN/dS ration was greater than 1 for some housekeeping genes in all isolates. This is the first time that some loci under positive selection were identified. These observations confirm frequent recombination events in V. parahaemolyticus. Recombination was much more important than mutation for genetic heterogeneity of the food isolates, but the probabilities of recombination and mutations were almost equal for the clinical isolates. Based on the phylogenetic analysis, the clinical isolates were concentrated in the maximum-likelihood tree, while the food isolates were heterogeneously distributed. In conclusion, the food and clinical isolates of V. parahaemolyticus from the Guangdong Province are similar, but show different evolutionary trends. This may help prevent large-scale spread of highly virulent strains and provides a genetic basis for the discovery of microevolutionary relationships in V. parahaemolyticus populations.
On-Line Estimation Method of Lithium-Ion Battery Health Status Based on PSO-SVM

Battery management system (BMS) refers to a critical electronic control unit in the power battery system of electric vehicles. It is capable of detecting and estimating battery status online, especially estimating state of charge (SOC) and state of health (SOH) accurately. Safe driving and battery life optimization are of high significance. As indicated from recent literature reports, most relevant studies on battery health estimation are offline estimation, and several problems emerged (e.g., long time-consuming, considerable calculation and unable to estimate online). Given this, the present study proposes an online estimation method of lithium-ion health based on particle swarm support vector machine algorithm. By exploiting the data of National Aeronautics and Space Administration (NASA) battery samples, this study explores the changing law of battery state of charge under different battery health. In addition, particle swarm algorithm is adopted to optimize the kernel function of the support vector machine for the joint estimation of battery SOC and SOH. As indicated from the tests (e.g., Dynamic Stress Test), it exhibits good adaptability and feasibility. This study also provides a certain reference for the application of BMS system in electric vehicle battery online detection and state estimation.
The Non-linear Relationship Between Normal Range Systolic Blood Pressure and Cardiovascular or All-Cause Mortality Among Elderly Population

Purpose: The aim was to explore the association of normal range SBP with cardiovascular and all-cause mortality in older adults without hypertension. Methods: Participants aged ≥ 65 years without hypertension and those had an SBP level between 90 and 129 mmHg were included from the National Health and Nutrition Examination Survey (1999–2014). SBP was categorized into: 90–99, 100–109, 110–119, and 120–129 mmHg. Multivariate Cox regression was performed with hazard ratio (HR) and 95% confidence interval (CI). Results: Of the 1,074 participants, 584 were men (54.38%). Compared with participants with SBP level ranged 110 to 119 mmHg, the HRs for all-cause mortality risk was 1.83 (95% CI: 1.04, 3.23) for SBP level ranged 90 to 99 mm Hg, 0.87 (95% CI: 0.54, 1.41) for SBP level ranged 100 to 109 mmHg, and 1.30 (95% CI: 0.96, 1.75) for SBP level ranged 120 to 129 mmHg (P for trend = 0.448), and the HR for cardiovascular mortality risk was 3.30 (95% CI: 0.87, 12.54) for SBP level ranged 90 to 99 mmHg, 0.35(95% CI: 0.08, 1.56) for SBP level ranged 100 to 109 mmHg, and 1.75 (95% CI: 0.78, 3.94) for SBP level ranged 120 to 129 mm Hg (P for trend = 0.349) after confounders were adjusted. Conclusion: These were a nonlinear association of normal range SBP level with all-cause and cardiovascular death in older adults.
Suicide Exposure in a Polymediated Age

With growing evidence that media plays a vital role in shaping public understanding of suicidality and influencing behaviours, media portrayals of suicidality have for some time been the focus of suicide prevention efforts. Traditional media has changed, and now exists alongside and within an instantaneous, interactive sharing of information created and controlled by anyone; the way most people use it today incorporates a wide variety of online communication media. Polymedia describes media communication as both a product and process, where anyone can contribute and act as producers, consumers, audiences, and critics. In a “Polymediated age,” media exposure becomes much more complex. To understand how media exposure to suicide influences and impacts on others, it is important to take into account the communicative ecology of media technologies and the different interactions we can have with them. We researched the effects of this type of exposure by conducting in-depth interviews with a purposive sample of individuals who have lived experience and/or knowledge of suicide exposure via polymediated communication in the aftermath of a suicide. Using thematic analysis, our data demonstrates how exposure to suicide has become more complex as a result of new communicative media technology: it can be both a gift and a curse, difficult to distinguish, predict or control. Polymedia has the power to determine new forms of narrative and new forms of behaviour that on the one hand can provide support and prevention efforts, while on the other hand can promote conflict and cast an adverse influence on suicidal behaviour. Polymedia provides novel affordances for very intimate collective exposure to suicide. Our findings shed important new light on how the interplay between news media and social media has transformed our relationship with the information to which we’re exposed. We highlight important suggestions for those working in suicide prevention to develop (1) media strategies that recognise the multiple ways in which users are exposed and impacted, and (2) mechanisms for a strategic amplification and moderation of specific types of content. Media organisations and users of social media alike can contribute to maximising the beneficial capacity of polymediated exposure to suicide.