Miracle-dz/UniFAR-FTUs huggingface dataset:
Posttransplant de novo donor specific HLA antibody monitoring and clinical outcomes: a single-center experience

Objectives: Despite the improvements in early-term outcomes of kidney transplantation, late-term graft failure still remained as a critical problem. De novo donor specific antibodies (DSA) developing against direct human leukocyte antigens (HLA) are the significant risk factors for shortened graft survival in the previously nonsensitized cases. The purpose of this study is to evaluate the clinical outcomes of de novo DSA development in the kidney transplant cases. Methods: The present study included 121 (alive/cadaver: 106/15) of 148 (alive/cadaver: 125/23) cases who were not previously sensitized (PRA and DSA negative) and undergone kidney transplantation between August 2012-January 2018. DSAs of the cases without expected declines in creatinine levels in the polyclinic follow-ups and postoperative early-term were evaluated. Renal biopsy was performed in the cases encountered with > 2000 mean fluorescence intensity (MFI) de novo DSA against HLA-A, HLA-B, HLA-DR. Treatment protocol of plasmapheresis+intravenous immunoglobulin (IVIG)+rituximab (in the cases without clinical response) was administered in the cases with antibody-mediated rejection (AMR) detected by renal biopsy. In addition, the presence of de novo non-DSA was also evaluated in the cases. The presence of de novo was encountered by identifying the specificities of anti-HLA antibody specificities using Luminex single antigen beads in the recipient serum. Results: De novo DSA (antibodies against HLA-A, HLA-B, HLA-DR and HLA-DQ) were monitored in 23 cases. DQ positivity was detected in 10 cases. MFI values were > 4000 and 2000-4000 in 8 and 2 cases, respectively. De novo non-DSA was found in 19 cases. Biopsy was performed in 8 cases due to the development of MFI > 2000 de novo DSA against HLA-A, HLA-B and HLA-DR and the findings of acute humoral rejection (AHR) were encountered in 2 cases. Additionally, acute humoral rejection was diagnosed in 1 case that developed de novo non-DSA. Two cases were diagnosed with AHR by biopsy although no de novo DSA or non-DSA developed and renal graft loss occurred in these two cases. Conclusions: The fact that routine DSA monitoring in all the cases provided no significant contribution to the outcomes of our study may contribute to the debates on the necessity of DSA monitoring in the patients with low immunological risk.
Production of highly oxidized organic compounds from ozonolysis of beta-caryophyllene

We conducted a laboratory investigation to identify highly-oxidized organic compounds formed in sesquiterpene (C15H24, SQT) ozonolysis. The dominant sesquiterpene previously identified from branch emissions of Scots pine, β-caryophyllene, was used for this study. Using the latest mass spectrometric methods, we identified several highly oxidized organic compounds corresponding to RO2 radical, closed-shell monomer and dimer species. The most abundant compounds detected were monomers C15H24O7,9,11 and C15H22O9,11, and dimers C29H46O12,14,16 and C30H46O12,14,16. These oxidized organic compounds have very low saturation vapour pressures, an O-to-C ratio of about 0.3–0.9, and they are all classified as extremely low-volatility products (ELVOC). The molar yield of ELVOC was determined to be 1.7% ± 1.28%. Highly-oxidized organic compounds were also measured at a boreal forest site, and few possible β-caryophyllene oxidation products were identified, but the concentrations were extremely low, reaching a maximum of a few hundred thousand molecules cm–3 in spring.
Ambidexterity in Agile software development: a conceptual paper

PurposeThe purpose of this study is to apply the concept of organizational ambidexterity as a conceptual lens to increase the understanding of tensions between exploitation (continuity) and exploration (change) in Agile software development (ASD) project teams, and particularly the balancing (ambidextrous) strategies utilized.Design/methodology/approachA conceptual framework was constructed from interdisciplinary sources on ambidexterity. A literature review of publications on ambidexterity in ASD was then performed, and the results from the selected publications were classified according to an extension of the conceptual framework.FindingsContextual ambidexterity in ASD is affected by the four basic coherent concepts: time, task, team and transition. The study found that most ambidextrous factors and strategies were task and team-related. In addition, a mixture of hard (performance) strategies and soft (social) strategies is needed in order for people/teams to (be able to) become ambidextrous.Practical implicationsTo provide a better understanding of ASD, it is important to identify a broader set of ambidextrous factors and strategies that can impact ASD project teams. The expanded conceptual framework can serve as a basis for future empirical research and provide insights to practitioners on how to strengthen ambidexterity in ASD projects.Originality/valueThe contribution is of great importance for ASD research and practice, as ASD methods are a popular method for managing projects within ASD and in other nonsoftware organizations. In addition, as more and more organizations struggle to deal with rapidly changing environments, interest in the phenomena of paradoxical tensions and the strategy (ambidexterity) to deal with these tensions increase.
Textual analysis of online reviews as a lens for cross-cultural assessment

Purpose The purpose of this paper is to call researchers’ attention to cross-cultural research using online consumer reviews and multilingual textual analysis. Design/methodology/approach The authors discuss a selected literature review and the highlight of the four studies that show cross-cultural differences in online reviews on ethnic restaurants. Findings Applying multilingual textual analysis could prompt new venues to verify and expand future cross-cultural research in tourism and hospitality. Originality/value The paper introduces examples of multilingual textual analysis used for cross-cultural studies.
Propiedades psicométricas de la Escala de Gaudibilidad (Moduladores de Disfrute) para Niños y Adolescentes (EGNA).

La disminución de la capacidad de disfrute puede considerarse un factor de riesgo o indicador de presencia de trastornos mentales. Por ello, es de utilidad disponer de instrumentos válidos para evaluar la gaudibilidad en niños y adolescentes para desarrollar intervenciones que mejoren la gaudibilidad. El objetivo del presente trabajo fue construir y analizar las propiedades psicométricas de la Escala de Gaudibilidad para Niños y Adolescentes (EGNA). 1.264 estudiantes de primaria, secundaria y bachillerato respondieron a: EGNA, Escala de Autoestima de Rosenberg, Escalas Panas de afecto positivo y negativo para niños y adolescentes y la escala de Depresión del Centro de Estudios Epidemiológicos. Mediante un análisis factorial confirmatorio utilizando el método de estimación de máxima verosimilitud robusta se demostró un ajuste adecuado al modelo de 5 factores (Disfrute en compañía, Autoeficacia frente al aburrimiento, Sentido del humor, Imaginación e interés) relacionados. Además, se observó una consistencia interna adecuada (Cronbach α=0,794) en la escala total y en cada uno de los 5 factores. Finalmente se observó una adecuada validez concurrente y discriminante. La EGNA obtuvo adecuados indicadores respecto a su consistencia interna y validez. La EGNA es adecuada para cuantificar los niveles de gaudibilidad en niños y adolescentes. The decrease in the ability to enjoy can be considered a risk factor or marker of mental disorders. Therefore, it can be useful to have a scale to quantify gaudiebility in children and adolescents to develop strategies to improve gaudiebility. The objective of the present work was to build and analyze the psychometric properties of the Gaudiebility Scale for Children and Adolescents (GSCA). 1,264 primary, secondary and high school students responded to GSCA, Rosenberg’s self-esteem scale, Positive and Negative Affect schedule, Center of Epidemiological Studies of Depression scale. Through a confirmatory factor analysis using a robust maximum-likelihood estimation, an adequate adjustment was observed to 5 factors model (Enjoyment in Company, Self-efficacy versus boredom, Sense of humor, Imagination and Interest) related. In addition, an appropriate internal reliability (Cronbach α=0,794) was observed in the total scale and in the 5 subscales. Finally, an adequate concurrent and discriminant validities were observed. GSCA’s psychometric properties indicate appropriate internal reliability and validity. GSCA seems appropriate to quantify gaudiebility levels in children and adolescents.
Distributed Integrated Control of a Mixed Traffic Network With Urban and Freeway Networks

In the optimization of mixed urban and freeway networks, most existing control strategies implement centralized controllers that are not appropriate for real-time control in large-scale traffic networks due to the huge computational complexity. In this article, a distributed control framework for the cooperative control of mixed urban and freeway traffic networks is developed. First, an integrated traffic model is presented to characterize the interactions between the urban and freeway networks. In addition, a partitioning method is proposed, and then, the mixed traffic network is divided among urban agents and freeway agents for the easy implementation of the distributed control framework. The optimization problem of the whole network can then be decomposed into a number of suboptimization problems based on the partition of the network. In the proposed distributed control strategy, each agent solves its own optimization problem independently with local information and transmitted information from neighboring agents to seek the Nash equilibrium. Finally, the computational efficiency and the effectiveness of the distributed integrated control strategy of mixed traffic networks are evaluated through a numerical example.
Non-contact measurement system for hot water drilled ice boreholes

Abstract A programmable borehole measurement system was deployed in hot water drilled ice holes during the ‘Bed Access and Monitoring of Ice Sheet History’ (BEAMISH) project to drill to the bed of the Rutford Ice Stream in West Antarctica. This system operates autonomously (no live data) after deployment, and records borehole diameter (non-contact measurement), water column pressure, heading and inclination. Three cameras, two sideways looking and one vertical, are also included for visual inspection of hole integrity and sediments. The system is small, lightweight (~35.5 kg) and low power using only 6 ‘D’ cell sized lithium batteries, making it ideal for transport and use in remote field sites. The system is 2.81 m long and 165 mm in diameter, and can be deployed attached to the drill hose for measurements during drilling or on its own deployment line afterwards. The full system is discussed in detail, highlighting design strengths and weaknesses. Data from the BEAMISH project are also presented in the form of camera images showing hole integrity, and sensor data used to calculate borehole diameter through the full length of the hole. These data are used to show confidence in hole verticality and subsurface cavity development and connection.
Targeting the sodium iodide symporter (NIS) and apoptotic genes in extrathyroidal tumors.

Sodium Iodide Symporter (NIS), a therapeutic gene, was studied for the first time in retinoblastoma (RB) correlating the expression with clinicopathological invasiveness of the tumor. The specificity of EpCAM based NIS gene therapy was demonstrated in breast cancer cell as a proof of concept model via 1) EpCAM as tissue specific promoter and 2) nanoformulation, both of which showed encouraging outcomes. In addition, for the first time the upregulated expression of splice variants of survivin, Bax and Bcl-2 in RB tumors was explored indicating their possible role in tumor progression through apoptosis dysregulation. Thus, the above study achieved a profound knowledge about NIS and apoptotic genes in extrathyroidal tumors.
A Spatiotemporal Recurrent Neural Network for Prediction of Atmospheric PM2.5: A Case Study of Beijing

With rapid industrial development, air pollution problems, especially in urban and metropolitan centers, have become a serious societal problem and require our immediate attention and comprehensive solutions to protect human and animal health and the environment. Because bad air quality brings prominent effects on our daily life, how to forecast future air quality accurately and tenuously has emerged as a priority for guaranteeing the quality of human life in many urban areas worldwide. Existing models usually neglect the influence of wind and do not consider both distance and similarity to select the most related stations, which can provide significant information in prediction. Therefore, we propose a Geographic Self-Organizing Map (GeoSOM) spatiotemporal gated recurrent unit (GRU) model, which clusters all the monitor stations into several clusters by geographical coordinates and time-series features. For each cluster, we build a GRU model and weighted different models with the Gaussian vector weights to predict the target sequence. The experimental results on real air quality data in Beijing validate the superiority of the proposed method over a number of state-of-the-art ones in metrics, such as ${R} ^{2}$ , mean relative error (MRE), and mean absolute error (MAE). The MAE, MRE, and ${R} ^{2}$ are 16.1, 0.79, and 0.35 at the Gucheng station and 19.53, 0.82, and 0.36 at the Dongsi station.
Functional Properties of a Soy Isolate and a Soy Concentrate in Simple Systems as Related to Performance in a Food System

Two commercial soy protein products, Promine-D (a soy isolate) and Promosoy-100 (a soy concentrate), with protein contents on a moisture­ free basis of approximately 97 and 72% respectively, were studied. Part A of the study was,an investigation of protein solubility, hydration capacity, emulsion properties, fat absorptivity, and thickening function of the soy products in simple systems at pH levels of 5.0, 6.0, and 7.0 and at temperatures of 4 , ambient (22-25), and 90 C. The soy products were compared on both equal sample weight and equal protein bases. Part B involved evaluation of the functional performance of the soy products, compared on an equal protein basis, in food system base products and dips formulated from the base products. Base products prepared at pH 5. 0 and 6.0 and held at 4 and 90 C were evaluated for emulsion stability and apparent viscosity. Dips were held and evaluated at 4 ° by a consumer panel for viscosity, mouthfeel, oiliness, flavor, and general acceptability. The findings of Part A were related to those of B to evaluate the degree to which the simple system measurements could predict functional performance of the soy protein products in the food system selected. The isolate (P-D) was more soluble than the concentrate (P-100) at all pH-temperature combinations. Solubility of both soys generally increased as the pH of the dispersion increased. Solubility of P-D increased as temperature increased from 4 ° C to ambient, whereas the
An Analysis of Student Learning Anxiety During the COVID-19 Pandemic: A Study in Higher Education

Abstract The COVID-19 pandemic has become a global issue which has a broad impact, especially in the education world. This study aims to analyze students’ learning anxiety at the Universitas Raharja Indonesia during the COVID-19 pandemic. This research was conducted with regular student (morning classes) and non-regular student groups (afternoon classes) at the Universitas Raharja. The data collection technique was a closed questionnaire where respondents were given five alternative answers. The data were collected, analyzed descriptively, and categorized using the seven scales. The results showed that learning anxiety in the regular student group was 77.75% and in the non-regular student group was 81.05%. There was a difference in learning anxiety between regular and non-regular student groups, but it is not statistically significant.
Effects of the Three Gorges Projecton the Environment of Poyang Lake

Impounding by the Three Gorges Project (TGP) changed the hydrological process and affected the ecosystem in the middle and lower reaches of the Yangtze River. Poyang Lake is closely linked with the Yangtze River. This paper presents a coupled numerical model designed for simulating the tempo-spatial variation of water quantity and quality in the lake’s water system that features complex river-lake interactions. According to the calculated results of a typical year (2000) under two scenario schemes, we evaluated TGP’s effects on the ecological environment of the lake. The results show that due to TGP impoundment, the hydraulic gradient at the lake outlet has increased and that the outflow fluctuates dynamically and regularly with the increase and decrease of the TGP released discharge. The lake water level falls in advance and the average reduction magnitude of the water level decreases progressively from north to south, showing a spatially uneven effect, which is 0.95 m, 0.70 m, 0.74 m, 0.35 m, and 0.80 m at Xingzi, Tangyin, Duchang, Kangshan, and Wucheng stations, respectively. The ammonia nitrogen output from the lake to the Yangtze River increases and the total ammonia nitrogen amount within the lake region decreases. The average ammonia nitrogen concentration within the lake region tends to increase slightly and the influence magnitude on the concentration is reduced from north to south. The wetland vegetation area fluctuates dynamically with the decline of the water level, and the increase of the wetland vegetation area ranges from 0.64 to 215.48 km2. As a result of the falling water levels, the bottomlands in the lake region are exposed relatively earlier and the continuous exposure days increase, which intensifies the problem that migrant birds do not have enough food. Meanwhile the number of days when the bottomland and wetland are submerged decrease, which will further accelerate the degradation succession of wetland vegetation.
The Effect of Nutrition Support of Commercial Formula and FortemDia_Tri on Total Cholesterol Level and Blood Pressure in Type 2 Diabetes Mellitus Patients

— Most people with diabetes mellitus (DM) type 2 have increased lipid prevalence. An increase in cholesterol levels can reach 28% to 34%. High cholesterol levels accompanied by an increase in blood pressure in people with type-2 DM can increase the risk of cardiovascular disease. Proper nutritional support in the patient with type-2 DM is needed in controlling blood sugar along with controlling cholesterol levels and blood pressure. FortemDia_Tri is the development of a liquid dietary modification as nutritional support based on tempeh flour and mung beans as the main source of isoflavones and other ingredients such as skim milk flour, brown rice flour, canola oil, and maltodextrin, which are recommended for type-2 DM patients. Most commercial formulas do not contain isoflavones. The purpose of this research is to determine the effect of nutritional support for commercial formulas and FortemDia_Tri on reducing cholesterol levels and blood pressure in patients with type-2 DM. The sample of this study includes 33 patients with type-2 DM with the sample who neither takes insulin therapy nor consumes cholesterol-lowering drugs. Some samples were divided into 3 groups: control group (P1) given DM dietary education (n=11), P2 group given commercial formula (n = 11), and P3 group given the FortemDia_Tri (n=11). The dosage of commercial formula and FortemDia_Tri was 500 ml and 400 ml/day/person given 2 times/day, respectively. The intervention was done in 5 days. This study is analytical research with a randomized experimental study approach. The research design used is the pretest-posttest control-group design. The data of this research were analyzed with a one-way ANOVA test with the posthoc LSD test. After 5 days of treatment, there was a change in the level of total cholesterol of P2 group (-8.91 ± 23.17 mg/dl) with p = 0.231, and P3 group (-40.09 ± 25.04 mg/dl) with p = 0.000). Meanwhile, there was no change in the control group, and there was a significant difference between those groups (p = 0.001). P3 group has reduced more blood pressure than P1 and P2 groups, but the decrease was not different between the groups (p > 0.05). The FortemDia_Tri nutritional support can help reduce cholesterol levels and blood pressure in patients with type-2 DM. Further studies with longer duration and more sample sizes areneeded.
Spatial distribution overview of rotifers in the Yucatán peninsula, México

ABSTRACT The spatial distribution of rotifers in the aquatic ecosystems of the Yucatán peninsula is unclear. The peninsula is a karstic platform with heavy anthropogenic activity that presently puts pressure on and increases the fragmentation of aquatic systems. As the distribution of rotifers is unknown in this region, this study was performed to model spatial distribution of rotifers. Based on the analysis of their absence and presence in aquatic systems, using data from specimens collected in the field and bibliographic information from 1997 to 2018, our goal was to provide protection agencies as well as local and regional users with information on the distribution of microorganisms in the aquatic systems. With this material, an 877-record database with was produced. The bioregion outlined is an area in which 45 genera and 140 species of been observed; the study area contains 47.85% of all the rotifer species reported in Mexico. The essential genera in this bioregion are Brachionus with nine species, Keratella with three and Lecane with 44. In these three genera, we observed two morphotypes of rotifers: a small type in the southern zone and a large type in the northern zone.
Charging and Discharging Strategies of Electric Vehicles: A Survey

The literature covering Plug-in Electric Vehicles (EVs) contains many charging/discharging strategies. However, none of the review papers covers such strategies in a complete fashion where all patterns of EVs charging/discharging are identified. Filling a gap in the literature, we clearly and systematically classify such strategies. After providing a clear definition for each strategy, we provide a detailed comparison between them by categorizing differences as follows: complexity; economics and power losses on the grid side; ability to provide ancillary services for integrity of the power grid; operation aspects (e.g., charging timing); and detrimental impact on the EV, the power grid, or the environment. Each one of these comparison categories is subdivided into even more detailed aspects. After we compare the EV charging/discharging strategies, we further provide recommendations on which strategies are suitable for which applications. Then, we provide ratings for each strategy by weighting all aspects of comparison together. Our review helps authors or aggregators explore likely choices that might suit the specific needs of their systems or test beds.