Miracle-dz/UniFAR-FTUs huggingface dataset:
An Exploratory Study on the Perceived Challenges, Coping Strategies and Facilitating Factors for Optimal Implementation of Community-based Mental Health Services in Malaysia: A Study Protocol

Introduction: The present study aims to explore the perceived challenges, coping strategies, and facilitating factors for optimal implementation of community-based mental health services (CMHS) as the system of care for community mental health institutions (CMHI). The literature review has suggested that the aspects of barriers and facilitators are leading to the factors associated with the service provider, patient, provided treatment, and the healthcare system. However, there is a lack of centralised information about the current implementation of CMHS in Malaysia. The lack of readily-available information on the efficacy of CMHS as the system of care has led to this current inquiry. The study aims to explore on-the-ground experiences of the optimal implementation of CMHS in the CMHI in Malaysia through the perspective of mental healthcare professionals. Methods: This intended research will employ a qualitative approach and data will be collected through semi-structured in-depth interviews. Samples of the study will be recruited from in-service healthcare professionals attached to CMHI including psychiatrists, clinical psychologists, counsellors, occupational therapists, physiotherapists, nurses, and other related personnel. This study requires the respondents to give their opinions towards a set of interview questions that will consist of three (3) main questions. It is expected that each interview session takes about 40 minutes to 1 hour 30 minutes. Later, the interview transcripts will be analysed using the thematic analysis method. Expected results: The study is hoped to explore the experiences of in-service mental healthcare professionals in the CMHI and attempts to identify, describe, and investigate the components of perceived challenges, coping strategies, and facilitating factors towards the optimal implementation of CMHS through their point of view. Conclusion: It is vital to understand the perceived challenges, coping strategies, and facilitating factors towards the implementation of optimal CMHS to contribute to better planning and policy development vis-a-vis in the delivery of optimal services to the deserving community. Please click PDF below to download the full paper.
Potential distribution of a climate sensitive species, the White-winged Snowfinch Montifringilla nivalis in Europe

Summary The White-winged Snowfinch Montifringilla nivalis nivalis is assumed to be highly threatened by climate change, but this high elevation species has been little studied and the current breeding distribution is accurately known only for a minor portion of its range. Here, we provide a detailed and spatially explicit identification of the potentially suitable breeding areas for the Snowfinch. We modelled suitable areas in Europe and compared them with the currently known distribution. We built a distribution model using 14,574 records obtained during the breeding period that integrated climatic, topographic and land-cover variables, working at a 2-km spatial resolution with MaxEnt. The model performed well and was very robust; average annual temperature was the most important occurrence predictor (optimum between c.-3°C and 0°; unsuitable conditions below -10° and above 5°). The current European breeding range estimated by BirdLife International was almost three times greater than that classified as potentially suitable by our model. Discrepancies between our model and the distribution estimated by BirdLife International were particularly evident in eastern Europe, where the species is poorly monitored. Southern populations are likely more isolated and at major risk because of global warming. These differences have important implications for the supposed national responsibility for conservation of the species and highlight the need for new investigations on the species in the eastern part of its European range.
Drug-evoked synaptic plasticity of GABAB receptor signaling in the ventral tegmental area

Psychostimulants induce neuroadaptations in excitatory and fast inhibitory transmission in the ventral tegmental area (VTA). Mechanisms underlying drug-evoked synaptic plasticity of slow inhibitory transmission mediated by GABAB receptors and G protein-gated inwardly rectifying potassium (GIRK/Kir3) channels, however, are poorly understood. Here, we show that 1 day after methamphetamine (METH) or cocaine exposure both synaptically evoked and baclofen-activated GABABR-GIRK currents were significantly depressed in VTA GABA neurons and remained depressed for 7 days. Presynaptic inhibition mediated by GABABRs on GABA terminals was also weakened. Quantitative immunoelectron microscopy revealed internalization of GABAB1 and GIRK2, which occurred coincident with dephosphorylation of serine 783 (S783) in GABAB2, a site implicated in regulating GABABR surface expression. Inhibition of protein phosphatases recovered GABABR-GIRK currents in VTA GABA neurons of METH-injected mice. This psychostimulant-evoked impairment in GABABR signaling removes an intrinsic brake on GABA neuron spiking, which may augment GABA transmission in the mesocorticolimbic system.
Exploring the Pathogenic and Therapeutic Implications of Aberrant Splicing in Breast Cancer

Abstract : In this proposal, we set out to a) systematically monitor splicing variant profiles in breast cancer susceptibility genes and b) explore the role of alternative splicing in breast chemotherapy using a global strategy. In doing so, we hope to identify and validate candidate splicing variants involved in tumorigenesis using polony digital exon-profiling and functional assays. We are moving forward on four fronts - 1) the barcode methodology is in development; 2) we are working with state-of-the art capture arrays; 3) we are using the very latest RNA sequencing technology and 4) we are conducting comprehensive analyses of existing splice site variants in known breast cancer susceptibility genes. In part 3, we have generated over 5 million reads that have been aligned to the splice junction libraries, and we are using these reads to quantify and characterize alternative splicing events. Moreover, we will add value to this project by attempting to identify fusion proteins. In part 4, we have determined that the BRCA2 isoform known as BRCA2Δex12 is not associated with a recognizable phenotype. This work is now in press in Human Mutation.
Phase portraits of the quadratic polynomial Liénard differential systems

Abstract We classify the global phase portraits in the Poincaré disc of the quadratic polynomial Liénard differential systems \dot{x}=y, \quad \dot{y}=(ax+b)y+cx^2+dx+e,where (x, y) ∈ ℝ2 are the variables and a,b,c,d,e are real parameters.
A Filosofia Lean na Indústria Brasileira: Revisão da Literatura

This article aimed to analyze the application of Lean philosophy in the manufacturing industry in Brazil, over a period of ten years, to establish a relationship regarding trends, success factors, opportunities and identify gaps in the implementation of lean processes. The understanding of these factors, allows to know the status quo regarding the Lean practices in the productive and economic context of the Brazilian industry. The relevance of this research is to provide information that contributes to decision making and strategic actions for the continuous improvement of production processes. The method applied in this work was qualitative, descriptive, bibliographic research and with the use of content analysis, with “a priori” categorization under articles that address the theme and obtained from the Web of Science database. In the results and discussions, the SWOT and crossSWOT analysis were applied, establishing the relationships between the trends, success factors, opportunities and gaps allowing the establishment of the outline of important strategies for the future of the organizations and, also, proposing possible scenarios. for managers to establish their decision making.
Building key competencies into an environmental education curriculum using a modified Delphi approach in South Korea

Abstract This study adopted the modified Delphi method to build key competence indicators for the course subject ‘Environment’ in the secondary school curriculum in South Korea. 15 Delphi panelists participated, and were provided a three-stage questionnaire survey. The findings classified eight secondary school ‘environment’ curriculum key competencies into three domains: intellect-oriented, personality-oriented, and relationship-oriented. The intellect-oriented domain includes ‘critical-thinking ability,’ ‘creativity,’ and ‘problem-solving ability’; the personality-oriented domain includes ‘autonomy,’ ‘ability to reflect,’ and ‘environmental sensitivity’; and the relationship-oriented domain includes ‘communication ability’ and ‘ability to manage conflicts. ’ These environmental competencies were utilized to revise the current environmental education curriculum as part of the 2015 revision of the National Curriculum and set the key competencies for environment classes. The paper concludes with the significance of developments in theorizing and implementing environmental education curriculums in Korea and abroad.
PRODUCTIVE PERFORMANCE, CARCASS CHARACTERISTICS AND MEAT QUALITY OF BROILER CHICKENS AT DIFFERENT MARKETING AGES

Length of production cycle and broiler marketing decision is an important issue especially when productivity and product quality are considered. The objectives of this study were to determine the effects of the age at marketing on productive performance, carcass characteristics and meat quality traits of broiler chickens at five different ages. For this purpose, a total of 450 mixed-sex Cobb 500 broiler chicks were used. Chicks were randomly distributed into five equal groups with 3 replicates allocated in 15 pens. Broilers were reared until different marketing ages at 30, 35, 40, 45 and 50 days. Productive traits were recorded and performance indexes were calculated at different marketing ages. At each marketing day, a slaughter test was done using 12 birds subjected to a simplified carcass analysis. Breast muscles were used for evaluated meat quality and physicochemical properties. The results indicated that the age at marketing had significant effects (p<0.05) on all parameters investigated in point of productive traits, performance indexes, carcass traits, cut-up pieces and meat quality of broiler chickens. In conclusion, delaying marketing age positively increased live body weight and yield of live mass. But it negatively reduces feed efficiency, feed conversion ratio and livability % with increasing age which negatively affected the EPEF of broiler production. According to the EPEF, which expresses technical efficiency in one index, it can be stated that broiler production is only profitable with an EPEF at 30 th and 35 th days of age only. Thus, broiler farmers and producers have to differentiate or balance between ignoring some reduction in productive performance and compensating this with some added value from selling chicken in portions. But actually further research is required to find out an optimal marketing age in terms of economic considerations to calculate the costs and profits at different marketing ages.
Efficacy and Safety of Azilsartan Medoxomil and Telmisartan in Hypertensive Patients: A Randomized, Assessor-Blinded Study

Background: Few studies have compared the safety and efficacy of azilsartan medoxomil (AZL-M) and telmisartan in hypertensive patients, especially using ambulatory blood pressure monitoring (ABPM). Objective: The objective of this study was to compare the efficacy and safety profile of AZL-M and telmisartan in hypertensive patients using ABPM and clinic blood pressure (BP) monitoring. Materials and Methods: This prospective, randomized, open-label, blinded endpoint, parallel-arm study included 700 patients, aged 18–70 years, with clinic and 24-h mean ambulatory systolic BP (SBP) of 150–180 mmHg and 130–170 mmHg, respectively. They were randomized equally into two groups: Group A received AZL-M 40 mg and Group T received telmisartan 40 mg; the dose was force titrated to 80 mg after 2 weeks if the response rate was not achieved. BP (clinical and ambulatory) was measured after 12 weeks and compared with baseline measurements. Results: AZL-M significantly reduced the 24-h mean ambulatory SBP (Group A: 112.74 ± 7.58 mmHg; Group T: 113.96 ± 8.52 mmHg;P < 0.0001) and diastolic BP (Group A: 71.39 ± 5.89 mmHg; Group T: 67.29 ± 6.79 mmHg;P < 0.0001) compared with telmisartan at week 12. The clinic SBP significantly decreased in Group A at weeks 4 (−30.69± −0.33 mmHg) and 12 (−39.69± −1.09 mmHg) (for both, P = 0.0001). Dose titration was done in 99 and 128 patients from Group A and Group T, respectively (P = 0.012). Headache was the most common adverse drug reaction (Group A: 21; Group T: 27) and fatigue the least. Conclusion: This study found that AZL-M has greater antihypertensive efficacy than telmisartan, with comparable side effects. In addition, ABPM was shown to be a feasible method for such studies.
On the second-order holonomic equation for Sobolev-type orthogonal polynomials

ABSTRACT A general approach to the study of orthogonal polynomials related to Sobolev inner products which are defined in terms of divided-difference operators having the fundamental property of leaving a polynomial of degree n−1 when applied to a polynomial of degree n is presented. This paper gives analytic properties for the orthogonal polynomials, including the second-order holonomic difference equation satisfied by them.
Influence of Pre-Existing Nuclei on the Crystallization Kinetics of Primitive Alkaline Magmas: Insights on the Deep Feeding System of the Campi Flegrei Volcanic District

Aiming to evaluate the influence of pre-existing nuclei on the clinopyroxene crystallization kinetics, time-series experiments were performed using both natural and vitrified starting materials. Experiments were carried out at pressure of 0.8 GPa, temperatures between 1220 and 1250 °C, and dwell times ranging from 0.16 to 12 h. Clinopyroxene growth rates of the runs performed using the natural starting material containing pre-existing nuclei (~2 × 10−7 to ~6 × 10−8 cm∙s−1) are higher than those of the runs performed using the vitrified one (~3 × 10−7 to ~2 × 10−8 cm∙s−1). In both cases the growth rates decrease with increasing time. Conversely, clinopyroxene nucleation rates are lower in the experiments performed using the natural powder (102 and 10 mm−3∙s−1) compared to those performed with the glassy starting material (105 and 103 mm−3∙s−1). The nucleation rates tend to decrease increasing dwell time in all the series up to ~3 h, after which it remains nearly constant. Finally, the combination of the obtained clinopyroxene growth rates with the crystal size analysis of natural clinopyroxenes, allowed to estimate the magma ascent rate and the recharge rate of the Campi Flegrei Volcanic District deep reservoir.
HIV-1 Nef-Src Family Kinase Interaction: A Novel Target for the Inhibition of HIV-1 Pathogenesis

Human immunodeficiency virus-1 (HIV-1) is a lentivirus responsible for development of AIDS. In addition to typical retroviral proteins (Gag, Pol and Env), primate lentiviruses like HIV-1 encode two regulatory (Tat and Rev) and four accessory proteins (Vif, Vpu, Vpr and Nef). The HIV-1 accessory factor Nef is essential for high-titer viral replication and AIDS progression. Nef function requires interaction with many host cell proteins, including specific members of the Src kinase family. In this dissertation project, I explored whether Src-family kinase (SFK) activation is a conserved property of nef alleles from a wide range of primary HIV-1 isolates and its sensitivity to selective pharmacological inhibitors. Representative Nef proteins from the major HIV-1 subtypes A1, A2, B, C, F1, F2, G, H, J and K strongly activated Hck and Lyn as well as c-Src to a lesser extent, demonstrating for the first time that SFK activation is a highly conserved property of primary M-group HIV-1 Nef isolates. Moreover, patient-derived Nef proteins also strongly activated Hck. Recently, our group identified 4-amino diphenylfuranopyrimidines (DFPs) and diphenylpyrazolyldiazene (PPD-B9) compounds that selectively inhibit Nef-dependent SFK activation as well as HIV replication. To determine whether these novel compounds exhibit broad-spectrum Nef-dependent antiretroviral activity against HIV-1, I first constructed chimeric forms of the viral strain NL4-3 expressing the same 10 primary nef alleles. The infectivity and replication of these Nef chimeras was indistinguishable from that of wild-type in three distinct cell lines (MT2, U87MG and CEM-T4). Importantly, the 4-aminopropanol and 4-aminobutanol derivatives of DFP as well as PPD-B9 potently inhibited the replication of all chimeric forms of HIV-1 in both U87MG and CEM-T4 cells in a Nef-dependent manner. The effects of these compounds against HIV replication correlated with inhibition of Nef-dependent activation of endogenous SFKs. My results demonstrate that the activation of Hck, Lyn and c-Src by Nef is highly conserved among all major clades of HIV-1 and that selective targeting of this pathway uniformly inhibits HIV-1 replication. My results have strong public health significance for developing therapeutics against current drug resistant variants of HIV-1.
Competition in the Digital Age: Searching Responses to Strategic Challenges for Russia (Based on the Materials of the 18th International Scientific and Practical Conference “Competitive Russia: Foresight Model of Economic and Legal Development in the Digital Age”)

The era of digital technologies opens up promising opportunities at all levels of the state and social development, and determines fundamental changes in all spheres of human life. In preparation for these changes and unlocking their potential, policymakers in all countries of the world should pay special attention to the digital fundamentals of the economic transformation, so as not only to be able to enhance the competitiveness of the economic system, but also to smooth out the disruptive effects of emerging technologies. A special role in this context is played by the creation and functioning of scientific platforms for finding answers to such strategic challenges and threats, both for Russia and for all countries of the world. The International Scientific and Practical Conference “Competitive Russia: Foresight Model of Economic and Legal Development in the Digital Age” held at Volgograd State University and dedicated to the memory of Oleg Vasilyevich Inshakov, Honored Scientist of the Russian Federation, is one of such venues. Its results will serve as a fruitful methodological and theoretical basis for developing recommendations on systemic ensuring the competitiveness of the domestic economy in the context of the transition to a new technological structure and the implementation of a digital development scenario.
Type 2 diabetes does not exacerbate body heat storage in older adults during brief, extreme passive heat exposure

ABSTRACT Aging exacerbates hyperthermia and cardiovascular strain during passive heat exposure, but it remains unclear whether those effects worsen in older adults with type 2 diabetes (T2D). We examined these responses in unacclimatized, physically active, older individuals with (n = 13, mean ± SD age: 60 ± 8 years, HbA1c: 7.0 ± 1.0%) and without (Control, n = 30, 62 ± 6 years) well-controlled T2D during a brief, 3-h passive exposure to extreme heat (44°C, 30% relative humidity). Metabolic heat production, dry heat gain, total heat gain (metabolic heat production + dry heat gain), evaporative heat loss, body heat storage (summation of heat gain/loss), rectal and mean skin temperatures as well as heart rate were measured continuously. No between-group differences were observed for metabolic heat production (T2D vs. Control; 53 ± 5 vs. 55 ± 7 W/m2), dry heat gain (48 ± 9 vs. 47 ± 11 W/m2), total heat gain (101 ± 10 vs. 102 ± 14 W/m2) and evaporative heat loss (83 ± 10 vs. 85 ± 12 W/m2) over the 3 h (all P > 0.05). Consequently, the changes in body heat storage (380 ± 93 vs. 358 ± 172 kJ, P = 0.67) were similar between groups. Moreover, no between-group differences in rectal and mean skin temperatures or heart rate were measured. We conclude that unacclimatized, physically active, older adults with well-controlled T2D do not experience greater hyperthermia and cardiovascular strain compared to their healthy counterparts while resting in extreme heat for a brief, 3-h period.
Atoms and molecules in soft confinement potentials

ABSTRACT We present a detailed non-relativistic study of the atoms H, He, C and K and the molecule CH in the centre of a spherical soft confinement potential of the form with stiffness parameter N and confinement radius . The soft confinement potential approaches the hard-wall limit as , giving a more detailed picture of spherical confinement. The confined hydrogen atom is considered as a base model: it is treated numerically to obtain ground- and excited-state energies and nodal positions of the eigenstates to study the convergence towards the hard-wall limit. We also derive some important analytical relations. The use of Gaussian basis sets is analysed. We find that, for increasing stiffness parameter N, the convergence towards the basis-set limit becomes problematic. As an application, we report dipole polarisabilities for different values of N and of hydrogen. For helium, we determine electron correlation effects with varying N and , and discuss the virial theorem for both soft and hard confinements in the limit . For carbon, a change in the orbital population from 2s 2p to 2s 2 is observed with decreasing , while, for potassium, we observe a change from the S to D ground state at small values. For CH , we show that the one-particle density becomes more spherical with increasing confinement. A possible application of soft confinement to atoms and molecules under high pressure is discussed Prof. Jürgen Gauss observing Schrödinger's cat under quantum confinement. GRAPHICAL ABSTRACT
Early Mobilization on Patients with Mechanical Ventilation in the ICU

Patients in intensive care unit (ICU) usually experienced being immobile and restrained, and these can induce muscle weakness, cognitive impairments, psychological difficulties, difficult weaning, and increased length of stay (LOS) in hospital. However, early mobilization has multiple benefits including improved ventilation, perfusion, muscle strength, and functional capacity.