Miracle-dz/UniFAR-FTUs huggingface dataset:
Ja n 20 20 Neutral inclusions , weakly neutral inclusions , and an overdetermined problem for confocal ellipsoids ∗

An inclusion is said to be neutral to uniform fields if upon insertion into a homogenous medium with a uniform field it does not perturb the uniform field at all. It is said to be weakly neutral if it perturbs the uniform field mildly. Such inclusions are of interest in relation to invisibility cloaking and effective medium theory. There have been some attempts lately to construct or to show existence of such inclusions in the form of core-shell structure or a single inclusion with the imperfect bonding parameter attached to its boundary. The purpose of this paper is to review recent progress in such attempts. We also discuss about the over-determined problem for confocal ellipsoids which is closely related with the neutral inclusion, and its equivalent formulation in terms of Newtonian potentials. The main body of this paper consists of reviews on known results, but some new results are also included. AMS subject classifications. 35N25 (primary); 35B40, 35Q60, 35R30, 35R05, 31B10 (secondary)
Assemblage Theory to Explain the Information Technology Capability Development in Small Businesses

Most studies about Information Technology Capability (ITC) are based on the Resource-Based Theory (RBT) and are focused on its impact on strategic organizational variables. However, the ITC formation and development processes have been less addressed, presenting several challenges such as the confluence of physical, human and organizational aspects and its dynamism. The lack of explanatory power of RBT for overcoming these challenges lead us to explore other views. In this paper, we propose a framework based on Manuel DeLanda’s Assemblage Theory for conceptualizing the ITC and orienting the study of its development over time. The characteristics of the assemblage concept including heterogeneity, scalability, and dynamism allows us to tackle the ITC at the level of a whole, but also at the level of its components and the interactions between them. Additionally, we explore the fluid nature of ITC using the processes of stabilization and destabilization proposed in the theory.
Sensitivity of Radiative Fluxes to Aerosols in the ALADIN-HIRLAM Numerical Weather Prediction System

The direct radiative effect of aerosols is taken into account in many limited-area numerical weather prediction models using wavelength-dependent aerosol optical depths of a range of aerosol species. We studied the impact of aerosol distribution and optical properties on radiative transfer, based on climatological and more realistic near real-time aerosol data. Sensitivity tests were carried out using the single-column version of the ALADIN-HIRLAM numerical weather prediction system, set up to use the HLRADIA simple broadband radiation scheme. The tests were restricted to clear-sky cases to avoid the complication of cloud–radiation–aerosol interactions. The largest differences in radiative fluxes and heating rates were found to be due to different aerosol loads. When the loads are large, the radiative fluxes and heating rates are sensitive to the aerosol inherent optical properties and the vertical distribution of the aerosol species. In such cases, regional weather models should use external real-time aerosol data for radiation parametrizations. Impacts of aerosols on shortwave radiation dominate longwave impacts. Sensitivity experiments indicated the important effects of highly absorbing black carbon aerosols and strongly scattering desert dust.
The Effect of Exhaust Temperature on Urea-Water Decomposition in Marine SCR Systems

Reduction of nitrogen oxide (NO x ) emissions from ships due to environmental pollution and greenhouse gas impact has been made obligatory by regulations introduced by the International Maritime Organization (IMO). Basically, NO x emission control mechanisms are divided into primary methods and after-treatment methods. After-treatment methods focus on reducing NO x emissions from the exhaust gas by various methods. In this study, the efficiency of the urea transformation for different exhaust temperature values for a modelled Selective Catalytic Reduction (SCR) system has been investigated numerically. As a result of numerical model, isocyanic acid, temperature, urea and ammonia values have been determined for Urea-Water Solutions (UWS) process values. The study has been calculated by the computational fluid dynamics (CFD). The numerical results obtained were confirmed by experimental studies from the literature.
Unsupervised whale song decomposition with Bayesian non-parametric Gaussian mixture

In this work we propose to extend the finite parsimonious Gaussian mixture to the infinite case so that the classification of our data could be performed in one stage. We implemented the eigenvalue decomposition of the covariance matrix of each cluster to the Infinite Gaussian mixture model and made it parsimonious. We developed an MCMC algorithm (Gibbs sampling) to learn the various models and we named this approach the bayesian non-parametric parsimonious approach for cluster analysis. The new approach will be more flexible in terms of modeling and will automatically provide the partition of the data and the number of clusters. This approach will be applied into the challenging problem of Whale song decomposition NIPS4B challenge. These algorithms would also give efficient clustering on complex sequence of pulses, and then may allow muti-source/multi-animals labelling.
Establishment and Characterization of Canine Mammary Gland Carcinoma Cell Lines With Vasculogenic Mimicry Ability in vitro and in vivo

Mammary tumors affect intact and elderly female dogs, and almost 50% of these cases are malignant. Cell culture offers a promising preclinical model to study this disease and creates the opportunity to deposit cell lines at a cell bank to allow greater assay reproducibility and more reliable validation of the results. Another important aspect is the possibility of establishing models and improving our understanding of tumor characteristics, such as vasculogenic mimicry. Because of the importance of cancer cell lines in preclinical models, the present study established and characterized primary cell lines from canine mammary gland tumors. Cell cultures were evaluated for morphology, phenotype, vasculogenic mimicry (VM), and tumorigenicity abilities. We collected 17 primary mammary carcinoma and three metastases and obtained satisfactory results from 10 samples. The cells were transplanted to a xenograft model. All cell lines exhibited a spindle-shaped or polygonal morphology and expressed concomitant pancytokeratin and cytokeratin 8/18. Four cell lines had vasculogenic mimicry ability in vitro, and two cell lines showed in vivo tumorigenicity and VM in the xenotransplanted tumor. Cellular characterization will help create a database to increase our knowledge of mammary carcinomas in dogs, including studies of tumor behavior and the identification of new therapeutic targets.
Salmonella among humans of Asian countries

This review aims at comprehensively reporting the impact of Salmonellosis in humans of developing Asian countries, the mode of dissemination, the various methods of serotyping, drug-resistance and the distribution of different Salmonella serotypes in these countries. The review focusses mainly on developing Asian countries which have a big population, higher risk of dissemination of the pathogen due to poor standards of public hygiene and sanitation, and also a high rate of arriving and departing travellers. Moreover, most of these countries lack a proper continuous surveillance and control system to monitor the epizootiology of Salmonella serovars. Various serotypes that were prevalent in Asian countries included the following: S. weltevreden, S. rissen and S. typhimurium, S. anatum, S. rissen, S. stanley and S. enteritidis. A high degree of serotypes distribution was found among the different countries. Resistance to multiple drugs was present in many serovars. The reported results indicate an alarming rate of human Salmonellosis in developing Asian countries, highlighting the importance of developing stringent surveillance and control programs aiming at control of this pathogen. [Archana Iyer, Taha Kumosani, Jehad Mostafa Yousef, Elie Barbour, Steve Harakeh. Salmonella among humans of Asian countries. Life Sci J 2018;15(3):86-91]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite. com. 13. doi:10.7537/marslsj150318.13.
NEVER SAY NEVER ? ” : HETEROSEXUAL , BISEXUAL , AND “ Never Say Never ? ” : Heterosexual , Bisexual , and Lesbian Women ’ s Accounts of Being

Feminist scholars have identified a “motherhood imperative” in Western cultures, where heterosexual women are understood to both want, and have, children. However, social shifts have resulted in a decrease in pronatalism as well as an increase in social recognition of the parenting desires of same-sex parents. Despite a resurgence of interest in childfree identities, research to date has predominantly focused on heterosexual women’s explanations for being childfree and their experiences of marginalisation. Our aim in the current study was to explore how childfree heterosexual, lesbian, bisexual, and queer women negotiate their childfree lives and identities in the context of their personal and social relationships within changing cultural contexts. Data from 23 interviews with women in the United Kingdom, who responded to a call for childfree participants, were thematically analysed. We constructed two themes: 1) Never say never? Negotiating being childfree as ever precarious, shows how women constructed being childfree as requiring constant revisiting and renegotiating to maintain; 2) An ordinary life: Constructing being childfree as rational and reasonable, in which we identify the rhetorical efforts of participants to establish their being childfree as an ordinary, reasonable, and rational position. We conclude that for these women, childfreedom was constantly in flux and that maintaining a positive childfree identity required considerable identity work in order to manage intimate personal relationships and wider friendships.
Forum of ideas / Forum des idées

This study examines the evolution of 11 prospective secondary teachers' (PTs) understanding of mathematical modeling through the implementation of a modeling module in a curriculum course. The module consisted of readings, carefully designed modeling activities, individual and group work, discussion, presentations, and re ections. The results show that while most PTs had misconceived de nitions of mathematical modeling prior to the module, they developed the correct understanding of modeling as an iterative process involving making assumptions and validating conclusions connected to everyday situations. The study also reveals how the PTs translated the modeling cycle into practice in the context of a given problem. MSC : 97M06
The effect of human wharton’s jelly-derived mesenchymal stem cells on MC4R, NPY, and LEPR gene expression levels in rats with streptozotocin-induced diabetes

Objective(s): Type 1 diabetes (T1D) is an autoimmune disease resulting from inflammatory destruction of islets β-cells. Nowadays, progress in cell therapy, especially mesenchymal stem cells (MSCs) proposes numerous potential remedies for T1D. We aimed to investigate the combination therapeutic effect of these cells with insulin and metformin on neuropeptide Y, melanocortin-4 receptor, and leptin receptor genes expression in TID. Materials and Methods: One hundreds male rats were randomly divided into seven groups: the control, diabetes, insulin (Ins.), insulin+metformin (Ins.Met.), Wharton’s Jelly-derived MSCs (WJ-MSCs), insulin+metformin+WJ-MSCs (Ins.Met.MSCs), and insulin+WJ-MSCs (Ins.MSCs). Treatment was performed from the first day after diagnosis as diabetes. Groups of the recipient WJ-MSCs were intraportally injected with 2× 10⁶ MSCs/kg at the 7th and 28th days of study. Fasting blood sugar was monitored and tissues and genes analysis were performed. Results: The blood glucose levels were slightly decreased in all treatment groups within 20th and 45th days compared to the diabetic group. The C-peptide level enhanced in these groups compared to the diabetic group, but this increment in Ins.MSCs group on the 45th days was higher than other groups. The expression level of melanocortin-4 receptor and leptin receptor genes meaningfully up-regulated in the treatment groups, while the expression of neuropeptide Y significantly down-regulated in the treatment group on both times of study. Conclusion: Our data exhibit that infusion of MSCs and its combination therapy with insulin might ameliorate diabetes signs by changing the amount of leptin and subsequent changes in the expression of neuropeptide Y and melanocortin-4 receptor.
VOMITING AFTER GYNECOLOGICAL SURGERY

Postoperative nausea and vomiting (PONV) is a common complication after gynecological surgery and is a common reason for poor satisfaction in the postoperative period. The overall incidence of PONV ranges from 35% to 65% [1]. Various methods to manage PONV have been investigated, including both pharmacologic and nonpharmacologic approaches. Medications to prevent and treat PONV studied include serotonin antagonists, butyrophenones, metoclopramide, dexamethasone, and scopolamine [2–14]. One nonpharmacologic technique, acupuncture in the pericardium (P6), has been extensively studied and is an effective treatment for PONV [15–22]. Many other common oriental medical techniques have been used to prevent PONV [23]. Auricular acupuncture is reportedly effective in reducing PONV in female patients undergoing hysterectomy [15]. Acupressure is the application of pressure using beads, seeds, or other hard substances to specific acupuncture points. The effectiveness of auricular acupressure in preventing PONV has not been studied. We designed this study to investigate the effect of auricular acupressure in gynecological patients.
A modified multilevel Monte Carlo method for European style options valuation

This article proposes a modified multilevel Monte Carlo (MMLMC) method and tests the method in terms of variance estimation. Many MMLMC estimators can be constructed under the MMLMC framework and therefore we can find the finest estimator, which has the lowest variance, in numerical experiments. The numerical results show that many of the MMLMC estimators perform better than both the original multilevel Monte Carlo (MLMC) estimator and the standard Monte Carlo estimator and that thinning some of the levels in the MLMC estimator improves the estimate of variance for European vanilla and Lookback options pricing.
Near-duplicated Documents in CiteSeerX

Academic literatures, especially those in the field of computer science, are often posted multiple times on the Web. Scholarly index engines, such as Google Scholar and CiteSeerX, crawl such documents from the open web as well as publishers. To improve the quality of the search result, there is a need to detect and coalesce duplicate or very similar (hereafter called near-duplicate) papers. Near-duplicate detection is computationally expensive. Pair-wise comparison of millions of papers is not feasible even for the most advanced machines. We combine SimHash and Jaccard similarity to discover near-duplicate documents in a CiteSeerX data set, which contains 2,118,122 full-text academic papers. We observe that 12% documents in CiteSeerX have near-duplicates with Jaccard similarity larger than 0.9. Then we study the near-duplicates and summarize six leading causes. We also compare these near-duplicates with those appeared only once on the web. We find that the citation count grows almost linearly with the number of duplications.
S 1 Reanalysis of Nelson et al . Supplementary Datasets S 1 . 1 Replication of main text figures

Figure 1N In the supplementary and main results of this paper, we recreate figures from the original Nelson et al. publication with updated data sources. Before doing this, we determined if we could replicate the figures from supplementary data from the original paper (supplementary datasets 2, 3, and 4 of [2]). Figures and tables from the original publication will be referred to with the su x N, i.e. Figure 1N. Figure 1N [2] gives the total number of MeSH, genes, and gene-MeSH pairs in the Pharmaprojects database and the GWASdb separated by source. We exactly reproduce Figure 1N from supplementary tables if sources “dbGaP”, “GWAS:A”, “GWAS:B”, “GWASCentral”, “JohnsonOdonnell” and “Omim” are considered part of the GWASdb and source “OMIM” is the only source of OMIM associations. Source “Omim” appears to have been derived from the OMIM database, although it features SNP-trait links and is largely non-overlapping with reported “OMIM” associations. We elected to exclude this data source from both the GWASdb and OMIM datasets as we wished to have a clear separation between Mendelian genetic evidence and genetic evidence from GWAS.
Monitoring Ischemic Changes in Retinal Vasculitis With Optical Coherence Tomography Angiography

Purpose: This article illustrates the ability of optical coherence tomography angiography (OCTA) to aid in the diagnostic workup and management of occlusive retinal vasculitis over time. Methods: A case presentation is discussed. Results: In this case, OCTA helped define the extent and evolution of superficial and deep retinal capillary plexus occlusion and reperfusion over the treatment course. Conclusions: OCTA detects blood flow and maps retinal vasculature at the capillary level without the use of intravenous dye. Serial image acquisition can reveal patterns of ischemia and reperfusion in retinal vascular conditions as they evolve and respond to therapy, providing more granular information regarding the status of the retinal microvasculature that may guide treatment.
Recent Advances in Noble Metal (Pt, Ru, and Ir)-Based Electrocatalysts for Efficient Hydrogen Evolution Reaction

Noble metal (Pt, Ru, and Ir)-based electrocatalysts are currently considered the most active materials for the hydrogen evolution reaction (HER). Although they have been associated with high cost, easy agglomeration, and poor stability during the HER reaction, recent efforts to intentionally tailor noble-metal-based catalysts have led to promising improvements, with lower cost and superior activity, which are critical to achieving large-scale production of pure hydrogen. In this mini-review, we focus on the recent advances in noble-metal-based HER electrocatalysts. In particular, the synthesis strategies to enhance cost-effectiveness and the catalytic activity for HER are highlighted.
The somatic mutation landscape of Chinese Colorectal Cancer

Colorectal cancer (CRC) is the fifth leading cause of cancer-related death in China. The incidence of Chinese CRC has increased dramatically with the changes of dietary and lifestyle. However, the genetic landscape of Chinese colorectal cancer mutation is still poorly understood. In this study, we have performed whole exome-sequencing analysis of 63 CRC cases. We found that Chinese CRC were hypermutated, which were enriched in ECM-receptor interaction, antigen processing and presentation, and focal adhesion. Analysis with clinical characteristics indicated that the deficiency of CRC driver gene, FCGBP and NBPF1 conferred CRC development and was showed worse survival rates, which could be the novel regulators and, diagnostic and prognostic biomarkers for Chinese CRC. Taken together, the application of whole exome-sequencing unveiled previously unsuspected somatic mutation landscape in Chinese CRCs, which may expand the understanding of disease mechanisms and provide an alternative personalized treatment for Chinese CRC patients.
Combined Analysis of the Aberrant Epigenetic Alteration of Pancreatic Ductal Adenocarcinoma

Background Pancreatic ductal adenocarcinoma (PDAC) remains one of the most fatal malignancies due to its high morbidity and mortality. DNA methylation exerts a vital part in the development of PDAC. However, a mechanistic role of mutual interactions between DNA methylation and mRNA as epigenetic regulators on transcriptomic alterations and its correlation with clinical outcomes such as survival have remained largely uncovered in cancer. Therefore, elucidation of aberrant epigenetic alteration in the development of PDAC is an urgent problem to be solved. In this work, we conduct an integrative epigenetic analysis of PDAC to identify aberrant DNA methylation-driven cancer genes during the occurrence of cancer. Methods DNA methylation matrix and mRNA profile were obtained from the TCGA database. The integration of methylation and gene expression datasets was analyzed using an R package MethylMix. The genes with hypomethylation/hypermethylation were further validated in the Kaplan–Meier analysis. The correlation analysis of gene expression and aberrant DNA methylation was also conducted. We performed a pathway analysis on aberrant DNG methylation genes identified by MethylMix criteria using ConsensusPathDB. Results 188 patients with both methylation data and mRNA data were considered eligible. A mixture model was constructed, and differential methylation genes in normal and tumor groups using the Wilcoxon rank test was performed. With the inclusion criteria, 95 differential methylation genes were detected. Among these genes, 74 hypermethylation and 21 hypomethylation genes were found. The pathway analysis revealed an increase in hypermethylation of genes involved in ATP-sensitive potassium channels, Robo4, and VEGF signaling pathways crosstalk, and generic transcription pathway. Conclusion Integrated analysis of the aberrant epigenetic alteration in pancreatic ductal adenocarcinoma indicated that differentially methylated genes could play a vital role in the occurrence of PDAC by bioinformatics analysis. The present work can help clinicians to elaborate on the function of differentially methylated expressed genes and pathways in PDAC. CDO1, GJD2, ID4, NOL4, PAX6, TRIM58, and ZNF382 might act as aberrantly DNA-methylated biomarkers for early screening and therapy of PDAC in the future.
A Novel Surface Modification and Immobilization Method of Anti-CD25 Antibody on Nonwoven Fabric Filter Removing Regulatory T Cells Selectively

Anti-CD25 antibodies were immobilized on polypropylene (PP) nonwoven fabrics to specifically remove mouse regulatory T cells (Tregs) from mouse spleen cells. PP fibers were coated with peptide nanosheets, which were prepared by self-assembling of a mixture of X-poly(sarcosine)-b-(l-Leu-Aib)6 (X: glycolic acid or a phenylboronic acid) and Y-poly(sarcosine)-b-(d-Leu-Aib)6 (Y: glycolic acid or diazirine derivative). Anti-CD25 antibodies were immobilized by covalent linking between the sugar moiety of the antibody and the phenylboronic acid group on the peptide nanosheet. The removal rate of mouse Tregs from the mouse spleen cells was more than 95% only by passing the filters, while the nonspecific removal rates of other cells were less than 15%. The coating of peptide nanosheets on PP fibers was very effective to provide a suitable environment for the immobilized antibody to interact with the counterpart cells while the coating suppressed nonspecific adsorption of other cells.