Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification of candidate genes associated with the pathogenesis of small cell lung cancer via integrated bioinformatics analysis

The pathogenesis of small cell lung cancer (SCLC), a highly metastatic malignant tumor, remains unclear. In the present study, important genes and pathways that are involved in the pathogenesis of SCLC were identified. The following four datasets were downloaded from the Gene Expression Omnibus: GSE60052, GSE43346, GSE15240 and GSE6044. The differentially expressed genes (DEGs) between the SCLC samples and the normal samples were analyzed using R software. The limma package was used for every dataset. The RobustRankAggreg package was used to integrate the DEGs from the four datasets. Functional and pathway enrichment analyses were conducted using the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases with FunRich software and R software, respectively. In addition, the protein-protein interaction (PPI) network of the DEGs was constructed using the STRING database and Cytoscape software. Hub genes and significant modules were identified using Molecular Complex Detection in Cytoscape software. Finally, the expression values of hub genes were determined using the Oncomine online database. In total, 412 DEGs were identified following the integration of the four datasets, with 146 upregulated genes and 266 downregulated genes. The upregulated DEGs were primarily enriched in the cell cycle, cell division and microtubule binding. The downregulated DEGs were primarily enriched in the complement and coagulation cascades, the cytokine-mediated signaling pathway and protein binding. Eight hub genes and 1 significant module correlated to the cell cycle pathway were identified based on a subset of the PPI network. Finally, five hub genes were identified as highly expressed in SCLC tissue compared with normal tissue. The cell cycle pathway may be the pathway most closely associated with the pathogenesis of SCLC. NDC80, BUB1B, PLK1, CDC20 and MAD2L1 should be the focus of follow-up studies regarding the diagnosis and treatment of SCLC.
[Validation of the Portuguese version of the King's Health Questionnaire for urinary incontinent women].

OBJECTIVE To translate into Portuguese and evaluate the condition-specific quality of life King's Health Questionnaire (KHQ) for female urinary incontinence. METHODS Two Brazilian translators, aware of the aim of the project, prepared two versions of the KHQ into Portuguese, which were back-translated into English by two other English translators. The differences were harmonized and pre-tested in a pilot study. The final version of the KHQ and the "Short-Form Health Survey" (SF-36), which has already been translated and validated into Portuguese were simultaneously administered to 156 and 119 women respectively. KHQ's psychometric properties such as reliability (internal consistency and retest) and construct validity were tested. A retest was performed within 2 weeks from the start date. RESULTS The cultural adjustment process resulted in no changes in the KHQ Portuguese version, although for low schooling patients the questionnaire had to be read by the researcher during face-to-face interview. For all other patients, the KHQ was self-administered. KHQ's standardized Cronbach's alpha was 0.87 and when assessed by domains ranged from 0.49 to 0.92. Reliability measured by intraclass correlation (ICC) was considered moderate to strong for all domains and the severity measure scale ranged from 0.53 to 0.81. Pearson's correlation coefficient between KHQ and SF-36 was considered weak to moderate in the majority of the related domains, ranging from -0.27 to -0.53. CONCLUSIONS The KHQ Portuguese version was translated and adjusted for Brazilian women with urinary incontinence complaints. It represents an important tool for the assessment of incontinent women in clinical trials.
Spatially resolved single-cell multiomics map of human trophoblast differentiation in early pregnancy

The relationship between the human placenta, the extraembryonic organ built by the fetus, and the decidua, the mucosal layer of the uterus, is essential to nurture and protect the fetus during pregnancy. Extravillous trophoblast cells (EVTs) anchor the placenta and infiltrate the decidua, transforming the maternal arteries into high conductance vessels. Defects in trophoblast invasion and arterial transformation established during early pregnancy underlie common pregnancy disorders such as pre-eclampsia. Despite its importance, how EVT invasion is regulated in humans is still unclear due the inaccessibility of the entire pregnant uterus and, until recently, a lack of reliable in vitro models. Here, we have generated a spatially-resolved multiomics single-cell atlas of the entire maternal-fetal interface including the myometrium, allowing us to resolve the full trajectory of trophoblast differentiation. We have used this cellular map to elucidate the main regulatory programmes mediating EVT invasion and show that they are preserved in trophoblast organoids. We define the transcriptomes of the final cell states of trophoblast invasion: placental bed giant cells (fused multinucleated EVTs) and endovascular EVTs (which form plugs inside the maternal arteries). We reconstruct the cell-cell communication events contributing to trophoblast invasion and GC formation, and define the dual role of interstitial EVTs and endovascular EVTs in mediating arterial transformation during early pregnancy. Together, our data provides a comprehensive analysis of postimplantation trophoblast differentiation in humans that can be used as a blueprint to design accurate multilineage placental in vitro models.
EMPLOYING N2N ENTRÉE AVAIL IN MANETS YET REPETITION TO FILE SHARING

Replication of files is a superb approach to improve file convenience minimizing file querying delay. The improved contemplation on cell phone applying file discussing motivates study peer-to-peer file discussing on mobile random systems. Within our work we inspect the intricacy of allocating restricted sources for file replication for global optimal effectiveness of file searching in mobile random systems. We initiate a manuscript concept of resource meant for file replication that views node storage furthermore to node meeting capacity and focused resource allotment impact on common querying delay and obtain optimal file rule of replication that assign sources towards each file on foundation its recognition furthermore to size. We submit data replication strategies which pulls on rule, which estimate least global querying delay inside the completely distributed approach.
The Social Participation of Older Adults Living With a Visual Impairment

Abstract Aim: To explore the social participation for four older adults with a visual impairment to better understand how access and choice affect social participation. Methods: A qualitative study to explore the social participation of four older adults with a visual impairment that engage in social participation. Results: The following themes emerged: social participation facilitated by family support, social participation providing motivation for engagement in occupations, social participation providing meaning in life, and loss of participation resulting from visual impairment. Conclusions: The study highlights the importance of family support, and how occupations provide meaning, motivation, and opportunity for social participation.
Partial mimicry of the microtubule binding of tau by its membrane binding

Tau, as typical of intrinsically disordered proteins (IDPs), binds to multiple targets including microtubules and acidic membranes. The latter two surfaces are both highly negatively charged, raising the prospect of mimicry in their binding by tau. The tau-microtubule complex was recently determined by cryo-EM. Here we used molecular dynamics simulations to characterize the dynamic binding of tau K19 to an acidic membrane. This IDP can be divided into three repeats, each containing an amphipathic helix. The three amphipathic helices, along with flanking residues, tether the protein to the membrane interface. The separation between and membrane positioning of the amphipathic helices in the simulations are validated by published EPR data. The membrane contact probabilities of individual residues in tau show both similarities to and distinctions from native contacts with microtubules. In particular, a Lys that is conserved among the repeats forms similar interactions with membranes and with microtubules, as does a conserved Val. This partial mimicry facilitates both the membrane anchoring of microtubules by tau and the transfer of tau from membranes to microtubules.
Lane detection using Randomized Hough Transform

According to the report of the Royal Thai Police between 2006 and 2015, lane changing without consciousness is one of the most accident causes. To solve this problem, many methods are considered. Lane Departure Warning System (LDWS) is considered to be one of the potential solutions. LDWS is a mechanism designed to warn the driver when the vehicle begins to move out of its current lane. LDWS contains many parts including lane boundary detection, driver warning and lane marker tracking. This article focuses on the lane boundary detection part. The proposed lane boundary detection detects the lines of the image from the input video and selects the lane marker of the road surface from those lines. Standard Hough Transform (SHT) and Randomized Hough Transform (RHT) are considered in this article. They are used to extract lines of an image. SHT extracts the lines from all of the edge pixels. RHT extracts only the lines randomly picked by the point pairs from edge pixels. RHT algorithm reduces the time and memory usage when compared with SHT. The increase of the threshold value in RHT will increase the voted limit of the line that has a high possibility to be the lane marker, but it also consumes the time and memory. By comparison between SHT and RHT with the different threshold values, 500 frames of input video from the front car camera will be processed. The accuracy and the computational time of RHT are similar to those of SHT in the result of the comparison.
Light-GC: a lightweight and efficient garbage collection scheme for embedded file systems

Raw flash file systems are essential in today's cost-sensitive embedded systems and legacy embedded devices. The performance of raw flash file systems is often limited by their inefficient garbage collection (GC) due to the tight capacity of the onboard flash memory and CPU computing power. However, in real-world scenarios, we observed that the GC overhead can account for more than 85% of the total I/O time, which not only degrades the performance of the file system but also shortens the endurance of the flash chip. However, existing GC optimization used in high-end SSD or server-side file systems usually leads to high CPU and memory usage, which is not suitable for the embedded environment. In this paper, we propose LightGC, a low-complexity and high-efficiency GC scheme. We design an optimized clustering algorithm for page hotness measurement and a hot-delay GC victim selection strategy. LightGC can also be adapted to locality changes in workloads to maximize the effect of cold and heat separation. Our experimental results show that LightGC offers a relative improvement of up to 19% in GC efficiency, a 5%-15% reduction in write amplification, and a 10%-17% increase in flash memory endurance compared to other existing GC methods. In addition, driven by LightGC, we implement the UBIFS2 file system, an upgraded version of the UBIFS flash file system. We have done careful engineering design so that UBIFS2 and the original UBIFS are compatible with each other and users can switch between them freely.
Mapping and Imaging in Non-paroxysmal AF

Despite intense research efforts, maintenance of sinus rhythm in patients with non-paroxysmal AF remains challenging with suboptimal outcomes. A major limitation to the success of current ablation-based treatments is that our understanding of AF pathophysiology is incomplete. Advances in imaging and mapping tools have been reported to improve ablation outcomes. However, the role of these new approaches on the clinical care of patients with AF remains to be validated and better understood before wide adoption can occur. This article reviews the current techniques of imaging and mapping that can be applied in the management of patients with non-paroxysmal AF with a focus on their relevance to catheter ablation. Future applications and opportunities for new knowledge are also discussed.
USE OF ROTATIONAL THROMBOELASTOMETRY FOR OPTIMAL MANAGEMENT OF EARLY RESUSCITATION OF BLEEDING TRAUMA PATIENTS

Early trauma-induced coagulopathy (TIC) is associated with uncontrollable bleeding, high transfusion requirements and mortality. Current management strategies of coagulopathic bleeding trauma patients are either guided by untimely laboratory tests (goal-directed) or blind transfusion protocols according to pre-established formulas (damage-control, 1:1:1). Both strategies have significant limitations that may account for the poor outcome of many patients. Viscoelastometric tests such as rotational thromboelastometry (ROTEM  ) are emerging technologies with potential to revolutionize resuscitation of rapidly bleeding trauma patients. This project aims to investigate the role of ROTEM  in early trauma resuscitation, including TIC diagnosis, guiding blood transfusion and predicting 24h mortality. The overarching hypothesis is that ROTEM  parameters measured immediately upon hospital admission, may predict increased transfusion requirements, including massive transfusion (MT), and 24h mortality, and thus could guide blood and blood product transfusions. In order to explore this hypothesis, a series of approaches have been performed. A systematic review and international consensus conference with a panel of renowned experts in trauma, critical care, hematology, and surgery were done. They established the ROTEM  parameters and values used for the diagnosis of TIC, guidance of blood transfusion and prediction of 24h mortality. Next, patient data from two major Canadian iii trauma centers were obtained to develop and validate prediction models for assessing the risk of requiring blood and blood product transfusion (red blood cells (RBC), plasma, cryoprecipitate and platelets), massive transfusion (MT) and 24h mortality using ROTEM  and readily available clinical variables. The systematic review and the consensus conference indicated that low clot amplitude was associated with transfusion requirements, MT and 24h mortality but exact ROTEM  parameters values could not be determined due to equipment limitations (i.e. high coefficient of variability) and poor understanding of their physiologic meaning (i.e. meaning of hyper coagulability parameters). Similarly, patient data analysis demonstrated that low clot amplitude, both in extrinsic (EXTEM) and fibrinogen pathways (FIBTEM), along with clinical parameters, accurately predicted the need for plasma and cryoprecipitate transfusion, MT, and 24h mortality. ROTEM  however, did not predict RBC or platelet transfusion. The results of our studies indicate that ROTEM  may assist in the early diagnosis and guide timely management of bleeding coagulopathic injured patients. While our findings warrant future evaluations we speculate that ROTEM  can guide blood transfusions, reduce inappropriate blood utilization and improve patient outcome (reduce mortality).
Dysglycemia, Not Altered Sex Steroid Hormones, Affects Cognitive Function in Polycystic Ovary Syndrome

Abstract Context Polycystic ovary syndrome (PCOS) is a complex endocrine condition characterized by multiple reproductive and metabolic abnormalities. Because individual reproductive and metabolic abnormalities modulate working memory in the general population, there is growing interest in whether cognitive function is dually and negatively affected in PCOS. Objective To examine the association of reproductive and metabolic features with cognitive function in women with and without PCOS. Design An observational, cross-sectional study was conducted at an academic clinical research center in North America between 2006 and 2009. Common tests of working memory (i.e., manual dexterity, perceptual speed, and visuospatial ability) were performed by women with PCOS (n = 40) and control subjects (n = 40). Markers of sex steroid hormones, ovulatory function, and cardiometabolic health were also assessed. Results Reduced visuospatial ability was observed in women with PCOS compared with control subjects (P < 0.01). Reduced visuospatial ability was linked to higher levels of hemoglobin A1c in the entire study cohort, independent of body mass index or PCOS status. No associations were observed between visuospatial ability and reproductive features, after controlling for confounding variables. Conclusion Our findings support a role for glycemic control, and not PCOS per se, in cognitive dysfunction in women of reproductive age. Additional studies are needed to understand the short- and long-term effects of dysglycemia on brain health in women with PCOS, given their increased propensity for metabolic comorbidities, compared with control subjects.
Home-based physiotherapy programmes for individuals with neurological diseases: systematic review

Abstract Introduction: Home-based programmes have received increasing attention in rehabilitation, providing an opportunity to continue aspects of therapy, benefiting the retention of established intervention effects. Objective: To describe the available home-based physiotherapy programmes in neurorehabilitation for people with neurological diseases. Method: MEDLINE, EMBASE, Cochrane Library, OTseeker and PEDro were searched, no restrictions regarding the date of publication or language restrictions for randomized controlled clinical trial. The quality of the selected studies using the PEDro scale and the Cochrane Collaboration’s tool for assessing the risk of bias. Results: Fifteen articles met the eligibility criteria and quality assessment and were selected for the present systematic review. The findings supports the positive impact of home-based intervention, finding evidence in the changes in activity level, improvement in the control and muscle strength, balance and walking in patients with neurological conditions who perform rehabilitation program at home, with a good adherence of participants in total. Conclusion: Models of rehabilitative such as home-based programmes can be an alternative efficient method to deliver rehabilitation, showing to be beneficial in improving different aspects of activities, and participation.
Transcriptome Profiles of Human Visceral Adipocytes in Obesity and Colorectal Cancer Unravel the Effects of Body Mass Index and Polyunsaturated Fatty Acids on Genes and Biological Processes Related to Tumorigenesis

Obesity, a low-grade inflammatory condition, represents a major risk factor for the development of several pathologies including colorectal cancer (CRC). Although the adipose tissue inflammatory state is now recognized as a key player in obesity-associated morbidities, the underlying biological processes are complex and not yet precisely defined. To this end, we analyzed transcriptome profiles of human visceral adipocytes from lean and obese subjects affected or not by CRC by RNA sequencing (n = 6 subjects/category), and validated selected modulated genes by real-time qPCR. We report that obesity and CRC, conditions characterized by the common denominator of inflammation, promote changes in the transcriptional program of adipocytes mostly involving pathways and biological processes linked to extracellular matrix remodeling, and metabolism of pyruvate, lipids and glucose. Interestingly, although the transcriptome of adipocytes shows several alterations that are common to both disorders, some modifications are unique under obesity (e.g., pathways associated with inflammation) and CRC (e.g., TGFβ signaling and extracellular matrix remodeling) and are influenced by the body mass index (e.g., processes related to cell adhesion, angiogenesis, as well as metabolism). Indeed, cancer-induced transcriptional program is deeply affected by obesity, with adipocytes from obese individuals exhibiting a more complex response to the tumor. We also report that in vitro exposure of adipocytes to ω3 and ω6 polyunsaturated fatty acids (PUFA) endowed with either anti- or pro-inflammatory properties, respectively, modulates the expression of genes involved in processes potentially relevant to carcinogenesis, as assessed by real-time qPCR. All together our results suggest that genes involved in pyruvate, glucose and lipid metabolism, fibrosis and inflammation are central in the transcriptional reprogramming of adipocytes occurring in obese and CRC-affected individuals, as well as in their response to PUFA exposure. Moreover, our results indicate that the transcriptional program of adipocytes is strongly influenced by the BMI status in CRC subjects. The dysregulation of these interrelated processes relevant for adipocyte functions may contribute to create more favorable conditions to tumor establishment or favor tumor progression, thus linking obesity and colorectal cancer.
An effective topic-based ranking technique for categorised research articles

The number of research articles is increasing very rapidly on the web due to the large volume of research work happening everyday. Maintaining and searching the required articles according to the user requirements is the need of the hour. Classification and ranking are the two important techniques of information retrieval which can shed light in this direction. This paper proposes an effective ranking approach which is the follow-up of our earlier classification work in which by using the keywords extracted from the keyword section of the articles, a huge volume of articles are classified into their respective categories. To rank these articles in each category, the proposed ranking approach uses latent Dirichlet allocation which transforms the text into the topics and then applies inverted indexing technique on it. Five benchmark datasets are used for experimental work. Results obtained from the experiment indicate that the performance of the proposed ranking technique is promising.