Miracle-dz/UniFAR-FTUs huggingface dataset:
Phase-resolved X-ray spectroscopy of PSRB0656+14 with SRG/eROSITA and XMM-Newton

We present a detailed spectroscopic and timing analysis of X-ray observations of the bright pulsar PSRB0656 + 14. The observations were obtained simultaneously with eROSITA and XMM-Newton during the calibration and performance veriﬁcation phase of the Spektrum-Roentgen-Gamma mission (SRG). The analysis of the 100ks deep observation of eROSITA is supported by archival obser- vations of the source, including XMM-Newton , NuSTAR , and NICER. Using XMM-Newton and NICER, we ﬁrst established an X-ray ephemeris for the time interval 2015 to 2020, which connects all X-ray observations in this period without cycle count alias and phase shifts. The mean eROSITA spectrum clearly reveals an absorption feature originating from the star at 570eV with a Gaussian σ of about 70eV that was tentatively identiﬁed in a previous long XMM-Newton observation. A second previously discussed absorption feature occurs at 260–265eV and is described here as an absorption edge. It could be of atmospheric or of instrumental origin. These absorption features are superposed on various emission components that are phenomenologically described here as the sum of hot (120eV) and cold (65eV) blackbody components, both of photospheric origin, and a power law with photon index Γ = 2 from the magnetosphere. We created energy-dependent light curves and phase-resolved spectra with a high signal-to-noise ratio. The phase- resolved spectroscopy reveals that the Gaussian absorption line at 570eV is clearly present throughout ∼ 60% of the spin cycle, but it is otherwise undetected. Likewise, its parameters were found to be dependent on phase. The visibility of the line strength coincides in phase with the maximum ﬂux of the hot blackbody. If the line originates from the stellar surface, it nevertheless likely originates from a different location than the hot polar cap. We also present three families of model atmospheres: a magnetized atmosphere, a condensed surface, and a mixed model. They were applied to the mean observed spectrum, whose continuum ﬁt the observed data well. The atmosphere model, however, predicts distances that are too short. For the mixed model, the Gaussian absorption may be interpreted as proton cyclotron absorption in a ﬁeld as high as 10 14 G, which is signiﬁcantly higher than the ﬁeld derived from the moderate observed spin-down.
The Einstein Ring GAL-CLUS-022058s: a Lensed Ultrabright Submillimeter Galaxy at z = 1.4796

We report an ultrabright lensed submillimeter galaxy at z spec = 1.4796, identified as a result of a full-sky cross-correlation of the AllWISE and Planck compact source catalogs aimed at searching for bright submillimeter galaxies at z ∼ 1.5–2.8. Atacama Pathfinder Experiment (APEX)/LABOCA observations of the candidate galaxy reveal a source with flux S 870μ m = 54 ± 8 mJy. The position of the APEX source coincides with the position of the AllWISE mid-IR source and with the Einstein ring GAL-CLUS-022058s, observed with the Hubble Space Telescope. Archival VLT/FORS observations reveal the redshift of this Einstein ring, z spec = 1.4796, and the detection of the CO(5–4) line at z spec = 1.4802 with APEX/nFLASH230 confirms the redshift of the submillimeter emission. The lensed source appears to be gravitationally magnified by a massive foreground galaxy cluster lens at z = 0.36. We use Lenstool to model the gravitational lensing, which is close to a “fold arc” configuration for an elliptical mass distribution of the central halo, where four images of the lensed galaxy are seen; the mean magnification is μ L = 18 ± 4. We have determined an intrinsic rest-frame infrared luminosity of L IR ≈1012 L ⊙ and a likely star formation rate of ∼70–170 M ⊙yr−1. The molecular gas mass is M mol ∼ 2.6 × 1010 M ⊙ and the gas fraction is f = 0.34 ± 0.07. We also obtain a stellar mass log (M */M ⊙) = 10.7 ± 0.1 and a specific star formation rate log (sSFR/Gyr−1) = 0.15 ± 0.03. This galaxy lies on the so-called main sequence of star-forming galaxies at this redshift.
Dataset from HDX-MS Studies of IgG1 Glycoforms and Their Interactions with the FcγRIa (CD64) Receptor

This document presents hydrogen-deuterium exchange mass spectrometry (HDX-MS) data from measurements of three purified IgG1 glycoform samples, predominantly G0F, G2F, and SAF, in isolation and in complexation with the high-affinity receptor, FcγRIa (CD64). The IgG1 antibody used in this study, aIL8hFc, is a murine-human chimeric IgG1, which inhibits IL-8 binding to human neutrophils.
A rich fauna of subterranean short-range endemic Anillini (Coleoptera, Carabidae, Trechinae) from semi-arid regions of Western Australia

Abstract Globally, the great majority of Anillini species are endogean, adapted to live in the interstices of soil and leaf litter, while the extremely low vagility of these minute ground beetles gives rise to numerous shortrange endemic species. Until recently the Australian Anillini fauna was known only from leaf litter in rain forests and eucalypt forests in the wetter, forested regions of eastern and south eastern Australia, as well as Lord Howe and Norfolk islands. The first hypogean Anillini in Australia (17 species in six genera) were described in 2016 from mineral exploration drill holes in iron-ore bearing rocks of the Pilbara region in Western Australia, representing the first finding of the tribe deep underground in a semi-arid climate region. A further eight new genera and 20 new species are described herein, mostly from the Pilbara region as well as the semi-arid Kimberley and Goldfields regions; all were collected in mineral exploration drill holes. The following new genera are described: Erwinanillusgen. nov., Gregorydytesgen. nov., Pilbaraphanusgen. nov., Neoillaphanusgen. nov., Kimberleytyphlusgen. nov., Gilesdytesgen. nov., Pilbaradytesgen. nov., and Bylibaraphanusgen. nov. The following new species are described: Erwinanillus baehrisp. nov.; Gracilanillus hirsutussp. nov., G. pannawonicanussp. nov.; Gregorydytes ophthalmianussp. nov.; Pilbaraphanus chichesterianussp. nov., P. bilybarianussp. nov.; Magnanillus firetalianussp. nov., M. sabaesp. nov., M. salomonissp. nov., M. regalissp. nov., M. serenitatissp. nov.; Neoillaphanus callawanussp. nov.; Kimberleytyphlus carrboydianussp. nov.; Austranillus jinayrianussp. nov.; Gilesdytes pardooanussp. nov., G. ethelianussp. nov.; Pilbaradytes abydosianussp. nov., P. webberianussp. nov.; Bylibaraphanus cundalinianussp. nov.; and Angustanillus armatussp. nov. Identification keys are provided for all Australian anilline genera, and Western Australian species. All the described species are known from a single locality and qualify as short-range endemics. The Anillini are recognised as a significant and diverse element making up part of Western Australia’s remarkable subterranean fauna, and whose conservation may potentially be impacted by mining developments.
Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands

G-quadruplexes (G4) are non-canonical DNA structures found in the genome of most species including human. Small molecules stabilizing these structures, called G4 ligands, have been identified and, for some of them, shown to induce cytotoxic DNA double-strand breaks. Through the use of an unbiased genetic approach, we identify here topoisomerase 2α (TOP2A) as a major effector of cytotoxicity induced by two clastogenic G4 ligands, pyridostatin and CX-5461, the latter molecule currently undergoing phase I/II clinical trials in oncology. We show that both TOP2 activity and transcription account for DNA break production following G4 ligand treatments. In contrast, clastogenic activity of these G4 ligands is countered by topoisomerase 1 (TOP1), which limits co-transcriptional G4 formation, and by factors promoting transcriptional elongation. Altogether our results support that clastogenic G4 ligands act as DNA structure-driven TOP2 poisons at transcribed regions bearing G4 structures.
Impact of delirium on mortality in patients hospitalized for heart failure

Objective Heart Failure (HF) is one of the leading causes of hospitalization in the United States accounting for ≈800,000 hospital discharges and $11 billion in annual costs. Delirium occurs in approximately 30% of elderly hospitalized patients and its incidence is significantly higher among those admitted to the critical care units. Despite this, there has been limited exploration of the clinical and economic impact of delirium in patients hospitalized with acute HF. We hypothesized that delirium in HF is associated with excess mortality and hospital costs. Methods We queried the 2001-2014 Nationwide Inpatient Sample to identify hospitalizations that included a primary discharge diagnosis of HF (ICD-9-CM: 428.xx) and stratified them by presence or absence of delirium (ICD-9-CM: 239.0, 290.41, 293.0, 293.1, 348.31). Differences in in-hospital mortality, length of stay (LOS), and hospital costs were assessed using propensity-score matched cohorts. Results Major predictors of delirium included advanced age, Caucasian race, underlying dementia or psychiatric diagnoses, higher Elixhauser Comorbidity Index, renal failure, cardiogenic shock, and coronary artery bypass surgery. In the propensity-score matched analysis of 76,411 hospitalization with delirium compared to 76,612 without delirium, in-hospital mortality (odds ratio: 1.67, 95% CI: 1.51–1.77), LOS (rate ratio [RR]: 1.47, 95% CI: 1.45–1.51), and hospital costs (RR: 1.44, 95% CI: 1.41–1.48) were all statistically higher in the presence of delirium (all p < 0.001). Conclusion In patients hospitalized with HF, delirium is an independent predictor of increased in-hospital mortality, longer LOS, and excess hospital costs despite adjustment for baseline characteristics.
Relationship between morning blood pressure surge and the frontal plane QRS-T angle in newly diagnosed hypertensive patients

ABSTRACT Background Morning blood pressure surge (MBPS) plays an important role in target organ damage and major adverse cardiac events. The frontal QRS-T [f(QRS-T)] angle is the electrocardiographic marker and index of ventricular arrhythmogenic events. We aimed to investigate the relationship between MBPS and the f(QRS-T) angle, which is an indicator of ventricular repolarization disorder, in patients with newly diagnosed HT. Methods Between June 2020 and March 2021, 263 patients with newly diagnosed HT who were admitted to our outpatient clinic were prospectively included in the study. According to ambulatory blood pressure monitoring (ABPM), the patients were categorized into two groups: Group-I: low-value MBPS (<37 mm Hg), and group-II: high-value MBPS (≥37 mm Hg). The f(QRS-T) angle calculated from the 12-lead electrocardiogram and all other data were compared between the groups. Results A total of 186 newly diagnosed HT patients who met the inclusion criteria were included in the study. The average f(QRS-T) angle in Groups I and 2 was 21° ± 16° and 51° ± 30°, respectively (P < .001). According to multivariate regression analysis, T peak-end and MBPS were found to be independent predictors of the f(QRS-T) angle. Conclusions As a result of our study, we found that the f(QRS-T) angle was widened in patients with exaggerated MBPS. The cause of increased cardiovascular outcomes in patients with exaggerated MBPS may be explained by widened in the f(QRS-T) angle that is a ventricular repolarization parameter.
Identification of plant-based hexokinase 2 inhibitors: combined molecular docking and dynamics simulation studies

Abstract Cancer cells ferment glucose, even under aerobic conditions, following a phenomenon known as the ‘Warburg effect. ’ Hexokinase 2 (HK2) catalyzes the crucial step of phosphorylation of glucose for subsequent utilization in glycolysis and other pathways. HK2 has been proposed as a potential therapeutic target for anti-cancer therapy because of its enhanced expression in glucose-dependent tumors. Here, we have employed structure-based virtual screening using in-house library to identify potential phytoconstituents which could inhibit the HK2 activity. The initial hits were selected based on their binding affinity towards HK2 using the molecular docking approach. Subsequently, the filters for physicochemical properties, PAINS patterns and PASS evaluation were applied to find potential hits against HK2. Finally, we have identified epigallocatechin gallate (EGCG) and quercitrin, two natural compounds with appreciable binding affinity, efficiency and specificity towards the HK2 binding pocket. Both compounds were found to be binding preferentially to the HK2 active site and showed a decent set of drug-like properties. All-atom molecular dynamics (MD) simulations for 100 ns were carried out to see the conformational dynamics, complexes stability and interaction mechanism of HK2 with EGCG and quercitrin. MD simulation results showed that HK2 forms stable protein-ligand complexes with EGCG and quercitrin with consistency throughout the trajectory. Overall, these findings suggest that EGCG and quercitrin might be further exploited as promising scaffolds in the drug development process against HK2. Communicated by Ramaswamy H. Sarma
Effects of organic solid cattle manure application on nutritive value of winter cereal forages

ABSTRACT Nutritive value of winter cereal forages is one of interested subjects of farmers for animal feeding. Field experiments were established in 2007–2008 and 2008–2009 growing seasons in northeast Turkey to investigate the effect of organic solid cattle manure application (0, 10 and 20 Mg ha−1 yr−1) on nutritive value of three annual cereals for forage. The winter cereal forages were: wheat (Triticum aestivum L.), oat (Avena sativa L.) and rye (Secela cereale L.). ADF (acid detergent fiber), NDF (neutral detergent fiber) CP (crude protein), nitrogen, phosphorus, potassium, sulfur, calcium, copper, iron, magnesium, manganese, sodium, zinc and boron (N, P, K, S, Ca, Cu, Fe, Mg, Mn, Na, Zn and B) concentrations were researched in this study. Wheat had the highest CP, N, Ca, Cu, Na and Zn concentration, whereas oat had the lowest ADF and NDF and the highest K, Fe and Mn concentrations. The greatest Mg and P concentrations were determined in rye. Organic solid cattle manure applications had no effect on N and CP contents, but it decreased ADF and NDF contents. However, in most cases it positively affected the P, B, Cu, Fe, Mg and Na concentrations, whereas it decreased K, Ca, Mn and Zn concentrations. The results showed that wheat and oat are more nutritive species than rye in terms of animal feeding and the organic solid cattle manure, in some cases increased the nutritive values of wheat, oat and rye under organic agriculture conditions.
Age-related susceptibility to muscle damage following mechanotherapy in rats recovering from disuse atrophy.

The inability to fully recover lost muscle mass following periods of disuse atrophy predisposes older adults to lost independence and poor quality of life. We have previously shown that mechanotherapy at a moderate load (4.5 N) enhances muscle mass recovery following atrophy in adult, but not older adult rats. We propose that elevated transverse stiffness in aged muscle inhibits the growth response to mechanotherapy and hypothesize that a higher load (7.6 N) will overcome this resistance to mechanical stimuli. F344/BN adult and older adult male rats underwent 14-days of hindlimb suspension, followed by 7-days of recovery with (RE+M) or without (RE) mechanotherapy at 7.6 N on gastrocnemius muscle. The 7.6 N load was determined by measuring transverse passive stiffness and linearly scaling up from 4.5 N. No differences in protein turnover or mean fiber cross sectional area were observed between RE and RE+M for older adult rats or adult rats at 7.6 N. However, there was a higher number of small muscle fibers present in older adult, but not adult rats, which was explained by a 16-fold increase in the frequency of small fibers expressing embryonic myosin heavy chain. Elevated central nucleation, satellite cell abundance, and dystrophin -/laminin + fibers were present in older adult rats only following 7.6 N, while 4.5 N did not induce damage at either age. We conclude that age is an important variable when considering load used during mechanotherapy and age-related transverse stiffness may predispose older adults to damage during the recovery period following disuse atrophy.
Vulnerability and Resilience in Sensitive Research: The Case of the Quantitative Researcher

The emotional experiences of quantitative researchers, particularly while conducting sensitive research, are largely neglected. This article aims to advance the awareness of possible emotional strains for quantitative researchers engaged in sensitive research. It qualitatively assesses the ethical and emotional experiences of quantitative researchers conducting a study on aging of bereaved parents and people with a physical disability. Based on the detailed minutes of 66 weekly research meetings held during 2015–2017, a thematic analysis of the researchers’ experiences was performed. Our analysis identified two main themes: vulnerability and resilience. We delineate these themes, along with their subthemes and affinity to vicarious traumatization, moral stress, and vicarious posttraumatic growth. The current study is among the first to introduce the emotional and ethical experiences of the quantitative researcher. Tentative recommendations for the advancement of the researcher’s safety and well-being by training, institutional support, self-care skills, and policy development are provided.
Effects of restriction of activities and social isolation on risk of dementia in the community

ABSTRACT Objective: Social isolation and emotional isolation, i.e. loneliness, have been associated with dementia or cognitive decline. In contrast, the relationship of restriction of physical and instrumental activities of daily living to cognitive decline and dementia has been less studied. Design: We examined multiple quality of life (QoL) indicators, including isolation and restriction of activities, utilizing two validated scales in elders without dementia to determine their associations with cognitive decline and incident dementia that were followed longitudinally over 6 years. We comprehensively controlled for other symptom constellations, including depression and anergia. Setting: A large multi-ethnic prospective study was conducted in northern Manhattan, NYC. Participants: An ethnically diverse sample of 855 non-demented individuals at baseline participated. Measures: The following QoL scales were utilized: Restriction, Anergia, Isolation, Loneliness, and Affective Suffering. Results: Both Restriction (HR = 2.22, 95% CI [1.42, 3.47], P < .001) and Isolation (HR = 1.78, 95% CI [1.17, 2.70], P = 0.007) were associated with episodic memory and incident dementia, controlling for age, sex, and education. Loneliness and Affective Suffering (depression) were not associated with these outcomes (P’s > .1) with both Restriction and Isolation in the same model for the prediction of dementia, only Restriction remained significant (HR = 1.97, 95% CI [1.24, 3.14], P = 0.004). In cross-lagged panel analyses, Restriction and Isolation had reciprocal influences (P’s < .001), indicating that Restriction at the previous time point influenced current Isolation. Importantly, Restriction (but not Isolation) and Selective Reminding total recall memory demonstrated highly significant direct and reciprocal influences over time (P’s < .001). Conclusions: Restriction and Isolation were associated with incident dementia. Restriction played a more prominent role in its impact on memory decline. The development of these impairments in QoL, particularly Restriction, may provide warning signs of future cognitive decline and dementia and provide multiple and novel avenues for therapeutic interventions with the goal of delaying the development of cognitive decline and dementia.
An Analysis of Methylome Evolution in Primates

Abstract Although the investigation of the epigenome becomes increasingly important, still little is known about the long-term evolution of epigenetic marks and systematic investigation strategies are still lacking. Here, we systematically demonstrate the transfer of classic phylogenetic methods such as maximum likelihood based on substitution models, parsimony, and distance-based to interval-scaled epigenetic data. Using a great apes blood data set, we demonstrate that DNA methylation is evolutionarily conserved at the level of individual CpGs in promotors, enhancers, and genic regions. Our analysis also reveals that this epigenomic conservation is significantly correlated with its transcription factor binding density. Binding sites for transcription factors involved in neuron differentiation and components of AP-1 evolve at a significantly higher rate at methylation than at the nucleotide level. Moreover, our models suggest an accelerated epigenomic evolution at binding sites of BRCA1, chromobox homolog protein 2, and factors of the polycomb repressor 2 complex in humans. For most genomic regions, the methylation-based reconstruction of phylogenetic trees is at par with sequence-based reconstruction. Most strikingly, phylogenetic reconstruction using methylation rates in enhancer regions was ineffective independently of the chosen model. We identify a set of phylogenetically uninformative CpG sites enriched in enhancers controlling immune-related genes.
DPPH Scavenging Assay of Eighty Four Bangladeshi Medicinal Plants

This study was designed to screen out free radical scavenging potentiality of 84 medicinal plants. Stock solution of different plant extracts and standard were diluted to achieve suitable concentrations. A control was also prepared without plant extract solution. Then 0.004% DPPH solution was added. The mixtures were incubated in the room temperature for 30 minutes. Then the absorbance was measured at 517 nm against solvent in UV-spectrophotometer and then IC50 was calculated. In this experiment two standard were used- ascorbic acid and BHT. Both showed a significant IC50 value of 15. 5µg/mL, and 46. 54µg/mL respectively. Among 84 medicinal plants Syzygim cumini, Casuarina littorea, Borassus flabellifer, Enhydra fluctuans, and Minusops elengi exhibited highest radical scavenging potential with an IC50 value of 12. 816µg/mL, 14. 467µg/mL, 15. 755µg/mL, 15. 653µg/mL, and 20. 380µg/mL respectively. All these value are very close to the IC50 value of ascorbic acid and better than IC50 value of BHT (Butylated Hydroxy Toluene). Syzygim cumini is the most powerful scavenger among all tested medicinal plants and also most strong scavenger than ascorbic acid and BHT. Scavenging activity was found to increase in dose dependent manner. Another 30 medicinal plants exhibited good scavenging property and 14 medicinal plants showed moderate scavenging activity. The rest presented lower scavenging activity. This present study indicates that plants having good scavenging property may have various health beneficial effects and these plants can be considered as valuable source of bioactive components with high antioxidant properties.