Miracle-dz/UniFAR-FTUs huggingface dataset:
Design on micro power dissipation E/D NMOS reference source

In this study, a novel micro power dissipation E/D NMOS reference source circuit was presented. The circuit is simple in structure, but is practical. Compared with a traditional BiCMOS band-gap reference source, the micro power dissipation E/D NMOS reference source has a small static current, and eliminates the need of parasitic bipolar transistor and resistor. All you need to do is to add a depletion-mode N-MONFET process to a conventional P-well process technology. An E/D NMOS reference source circuit has been developed in 2 Vm silicon-gate self-aligned CMOS process technology. In the range -55 to 125degC, the static current measured was less than 2 muA, the voltage regulation measured was less than 2mV, and the temperature coefficient measured was less than 100ppm/degC.
Is Swedish Pension Reform the Right Medicine for Aging Europe?

Abstract Following the Second World War, the idea of the life course with distinct periods of education, work, and retirement became popular as a result of the alliance of interests of unions and management, with politicians seizing the opportunity to accommodate them. These “social partners” implemented benefit rules and created practices for using old age and disability to ease the exit of older workers. Although justifiable at the time, now those rules and practices hinder individual and employer incentives to invest in human capital and work environments that enable older workers to remain in the workforce. The article argues that the workforce environment of the coming half-century, which is relevant for persons born around 2000, is much different from that a hundred years earlier, which determined the opportunities for people born around 1900. People are healthier and live much longer and work environments are friendlier. The article argues that it is no longer justifiable to subsidize exit from the workforce around the age of 60 for healthy workers, especially in view of the coming labor shortage in Europe. It also argues that the introduction of the principles of the Swedish NDC pension reform in Europe would provide possibilities for flexible exit from the workforce and remove impediments to labor mobility in Europe, which are embedded in many of Europe's present pension arrangements.
Tissue engineering bone formation in novel recombinant human bone morphogenic protein 2-atelocollagen composite scaffolds.

BACKGROUND Bone morphogenic proteins (BMPs) are important bone-induction factors, and the development of a suitable carrier for BMPs is a critical step to achieve osteoinductive function. The aims of the present study were to evaluate, at the cellular and molecular levels, the feasibility of recombinant human BMP-2 (rhBMP-2)-collagen composite scaffold and its efficiency for carrying BMP-2 in ectopic bone formation in rats. METHODS Scaffolds with (test) or without rhBMP-2 (control) were made and implanted into the calf muscle of 16 5-week-old rats. The tissue responses to the scaffolds were examined by histology. Masson's trichrome and von Kossa stainings were performed to examine collagen matrix deposition and calcification at 3, 7, 10, and 14 days. Expressions of bone phenotypic markers, alkaline phosphatase, osteocalcin, osteopontin, and bone sialoprotein were detected by reverse transcription-polymerase chain reaction and immunohistochemistry. RESULTS No detectable adverse responses were noted around the implanted scaffolds, and the area of the resorbed scaffold had been replaced by young connective tissue by 3 to 7 days in both groups. In the rhBMP-2 composite scaffold, collagen matrix deposition was found in the implanted site on day 7 and initial signs of endochondral differentiation also appeared. Mineralization and the expressions of key bone proteins were demonstrated in chondroblasts and osteoblasts at 7 to 14 days. Molecular cascades of bone induction were not shown in control specimens. CONCLUSION The rhBMP-2-atelocollagen scaffold showed excellent biocompatibility and possessed a bone-inducing capacity in rat within 2 weeks, and, thus, may provide a potential application in tissue engineering of bone tissue.
Bandwidth Enhancement of On-Chip Transformers Using Negative Capacitance

This brief presents a novel technique for bandwidth enhancement of on-chip transformers using the negative capacitance (NCAP) circuit. Since the coupling capacitance between the primary and secondary windings of an on-chip transformer limits its operating bandwidth, floating NCAP is added to compensate for the effect of the coupling capacitance on the transformer's performance. Fabricated in a 0.13-μm complementary metal-oxide-semiconductor technology, the 4 : 4 on-chip transformer with NCAP exhibits a wideband frequency response with 1.6 dB added gain compared with the transformer without NCAP. In addition, the input and output return losses (S11 and S22) values are well below -10 dB over the bandwidth for the transformer with NCAP.
The human UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2- N-acetylglucosaminyltransferase II gene (MGAT2). Cloning of genomic DNA, localization to chromosome 14q21, expression in insect cells and purification of the recombinant protein.

UDP-GlcNAc:alpha-6-D-mannoside [GlcNAc to Man alpha 1-6] beta-1,2-N-acetylglucosaminyltransferase II (GlcNAc-T II, EC 2.4.1.143) is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. A 1.2-kb probe from a rat liver cDNA encoding GlcNAc-T II was used to screen a human genomic DNA library in lambda EMBL3. Southern analysis of restriction endonuclease digests of positive phage clones identified two hybridizing fragments (3.0 and 3.5 kb) which were subcloned into pBlueScript. The inserts of the resulting plasmids (pHG30 and pHG36) are over-lapping clones containing 5.5 kb of genomic DNA. The pHG30 insert (3.0 kb) contains a 1341-bp open reading frame encoding a 447-amino-acid protein, 250 bp of G + C-rich 5'-upstream sequence and 1.4 kb of 3'-downstream sequence. The pHG36 insert (3.5 kb) contains 2.75 kb of 5'-upstream sequence and 750 bp of the 5'-end of the open reading frame. The protein sequence showed the domain structure typical of all previously cloned glycosyltransferases, i.e. a short 9-residue putative cytoplasmic N-terminal domain, a 20-residue hydrophobic non-cleavable putative signal-anchor domain and a 418-residue C-terminal catalytic domain. Northern analysis of human tissues showed a major message at 3 kb and minor signals at 2 and 4.5 kb. There is no sequence similarity to any previously cloned glycosyltransferases including human UDP-GlcNAc:alpha-3-D-mannoside [GlcNAc to Man alpha 1-3] beta-1,2-N-acetylglucosaminyltransferase I (GlcNAc-T I) which has 445 amino acids with a 418-residue C-terminal catalytic domain. The human GlcNAc-T I and II genes (MGAT1 and MGAT2) map to chromosome bands 5q35 and 14q21, respectively, by fluorescence in situ hybridization. The entire coding regions of human GlcNAc-T I and II are each on a single exon. There is 92% identity between the amino acid sequences of the catalytic domains of human and rat GlcNAc-T II. Southern analysis of restriction enzyme digests of human genomic DNA indicates that there is only a single copy of the MGAT2 gene. The full-length coding region of GlcNAc-T II has been expressed in the baculovirus/Sf9 insect cell system, the recombinant enzyme has been purified to near homogeneity with a specific activity of about 20 mumol.min-1.mg-1 and the product synthesized by the recombinant enzyme has been identified by high-resolution 1H-NMR spectroscopy and mass spectrometry.
Efficient 2-fold contextual filtering approach for fingerprint enhancement

Automated personal authentication has become increasingly important in modern information driven society and in this regard fingerprint-based personal identification is considered to be the most effective tool. In order to ensure reliable fingerprint identification and improve fingerprint ridge structure, a novel fingerprint enhancement approach is presented based on local adaptive contextual filtering. The proposed enhancement technique is 2-fold as it involves processing both in frequency and spatial domain. The fingerprint image is first filtered in frequency domain and then local directional filtering in spatial domain is applied to obtain enhanced fingerprint. In order to determine the performance efficiency of the proposed enhancement technique, a comparative analysis of error rates on standard fingerprint databases has been presented with major contextual enhancement schemes. The results show the efficacy of the proposed scheme as compared with other contextual filtering techniques.
Aging of secondary organic aerosol generated from the ozonolysis of α-pinene: effects of ozone, light and temperature

Abstract. A series of experiments was conducted in the CESAM (French acronym for Experimental Multiphasic Atmospheric Simulation Chamber) simulation chamber to investigate the evolution of the physical and chemical properties of secondary organic aerosols (SOAs) during different forcings. The present experiments represent a first attempt to comprehensively investigate the influence of oxidative processing, photochemistry, and diurnal temperature cycling upon SOA properties. SOAs generated from the ozonolysis of α-pinene were exposed under dry conditions ( No change in SOA size or chemical composition was observed during O3 and light exposure at constant temperature; in addition, GF and CRI of the SOA remained constant with forcing. On the contrary, illumination of SOAs in the absence of temperature control led to an increase in the real part of the CRI from 1.35 (±0.03) to 1.49 (±0.03), an increase of the GF from 1.04 (±0.02) to 1.14 (±0.02) and an increase of the f44 / f43 ratio from 1.73 (±0.03) to 2.23 (±0.03). The simulation of the experiments using the master chemical mechanism (MCM) and the Generator for Explicit Chemistry and Kinetics of Organics in the Atmosphere (GECKO-A) shows that these changes resulted from the evaporation of semi-volatile and less oxidized SOA species induced by the relatively minor increases in temperature (~ 6 °C). These surprising results suggest that α-pinene–O3 SOA properties may be governed more by local temperature fluctuations than by oxidative processing and photochemistry.
Diagnosis the Neurodegenerative Diseases using Graph-Based Visual Saliency ( GBVS ) with RVM Classifier

Neurodegenerative diseases leads to progressive loss of structure or function of neurons and also causes death of neuron its growth cannot be identified by Visual analysis done by radiologists, who can scarcely measure the systematic differences.The automatic quantitative analysis of brain form which observes the brain pattern does not provide detailed information about the affected region. This methods used for classification but does not provide functional information about the anatomical pattern. This paper presents about the image processing techniques that expose the affected regions in brain that is related to the presence of neurodegenerative diseases, mining systematic differences and identify the evaluation of neurodegenerative disorder. The fusion strategy that comprises bottom-up and top-down information flows is used. This process provides accurate delineation of object boundaries that cannot Rubini T.D Priyadharshini C B.E-CSE B.E-CSE K.R. C.T, K.R. C.T, Trichy,India Trichy,India be achieved by either the top-down or bottom-up approach alone. Bottom-up provides information by analyzing multiple images while the topdown stage includes learning and highlighting the affected regions. Extracting K-means clustering, Gray Level Cooccurrence matrix (GLCM) and Principal Component Analysis(PCA). Finally the extracted features are classified by relevance vector machine (RVM) which is a multiclass classifier to provide the multi class result. The Relevance Vector Machine (RVM) is a machine learning technique that uses Bayesian inference to obtain solutions for regression and probabilistic classification . The RVM has an identical functional form to the support vector machine. It achieves very good generalization performance and yields sparse models that provide inference at moderate computational cost.The main objective is to identify and project the affected brain patterns and reported for clinical studies related to several mental disorders.
Lateral Diffusion of Visual Pigment in Photoreceptor Disk Membranes

Visual pigment molecules are found to move transversely, but not longitudinally, in both rod and cone outer segments of mud puppy and frog. This is consistent with the idea that they are immersed in a two-dimensional fluid disk membrane. The diffusion coefficient for the motion is about 5 x 10-9 square centimeters per second at 20�C, corresponding to a root-mean-square molecular displacement of 0.3 micrometer in 1 second.
Nucleotide Sequence of a cDNA Coding for Cyclophilin of the Sea Urchin Hemicentrotus pulcherrimus

Abstract We present the nucleotide sequence of a cDNA coding for cyclophilin homologue of the sea urchin Hemicentrotus pulcherrimus. The 1,755-nucleotide sequence contains a 492-bp open reading frame corresponding to a translation product of 164 amino acids. Comparison of the deduced amino acid sequence with the previous data shows a high degree of conservation (∼80% homology). Southern blot analysis of genomic DNA suggests the presence of a multi-gene for sea urchin cyclophilin. Northern blot analysis indicates a mRNA size of ∼3 kb and that message is accumulated at blastula stage.
Simplified mammalian DNA isolation procedure.

The reverse genetics technologies that have recently been developed for mice have provided new tools to probe gene function in vivo. Unfortunately these powerful systems often require the analysis of large numbers of DNA samples. The genetargeting technology requires screening of embryonic stem-cell clones and later of the mice themselves, the latter also being the case for standard transgenic technology. It is not always possible or desirable to rely on PCR analyses, necessitating the isolation of large numbers of DNA samples of sufficient quality for Southern blot analysis. We have simplified the standard mammalian DNA isolation procedure with the aim of minimizing the number of manipulations required for each sample. The basic procedure applied to cultured cells does not require any centrifugation steps or organic solvent extractions.
Robust predictive filtering schemes for sub-band CQI feedback compression in 3GPP LTE systems

The third generation partnership project (3GPP) long-term evolution (LTE) cellular system offers high data rate capabilities by leveraging several techniques including link adaptation and frequency selective scheduling. These techniques rely on accurate channel quality indicator (CQI) feedback reports that are sent by the user equipment (UE) to the evolved node B, a process which results in high signalling overhead. In this study, the authors propose a UE-assisted sub-band feedback compression scheme based on a predictive filtering technique to reduce this signalling overhead. Four schemes based on adaptive filters have been designed, implemented and tested in an LTE system level simulator. Simulation results indicate that the proposed compression scheme has shown efficacy with an overall CQI feedback signalling reduction of up to 92.5% whilst maintaining stable sector throughput, when compared with the standard 3GPP CQI feedback mechanism. Although the proposed scheme exhibits low computational and memory complexity, a reduced-complexity scheme achieving an average computational load reduction of up to 35% is also presented.
A Multi-Agent Alphavirus DNA Vaccine Delivered by Intramuscular Electroporation Elicits 1 Robust and Durable Virus-Specific Immune Responses in Mice and Rabbits and Completely 2 Protects Mice against Lethal Venezuelan , Western , and Eastern Equine Encephalitis Virus 3 Aerosol Challenges

1 Robust and Durable Virus-Specific Immune Responses in Mice and Rabbits and Completely 2 Protects Mice against Lethal Venezuelan, Western, and Eastern Equine Encephalitis Virus 3 Aerosol Challenges 4 5 Lesley C. Dupuy,# Michelle J. Richards, Brian D. Livingston,* Drew Hannaman, Connie S. 6 Schmaljohn 7 8 United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, 9 USA; Ichor Medical Systems, Inc., San Diego, California, USA 10 11 Running Title: Multi-Agent Alphavirus DNA Vaccine Protects Mice 12 13 #Address correspondence to Lesley C. Dupuy, lesley.c. dupuy.ctr@mail.mil. 14 *Present address: Gilead Sciences, Inc., Foster City, California, USA 15 16 Abstract Word Count: 247 17 Text Word Count: 8,949 18 19 DISTRIBUTION STATEMENT A: Approved for public release; distribution is unlimited.
MULTIMODAL BEHAVIOR THERAPY: TREATING THE “BASIC ID”

This paper examines the necessary and sufficient conditions for achieving long-lasting therapeutic change. The rationale for recommending direct intervention across seven distinct but inter-related modalities is outlined in some detail. Other systems of psychotherapy are briefly compared to the multimodal behavior therapy procedures advocated herein. A case presentation is provided in order to lend substance to the general notion that durable clinical results are in direct proportion to the number of specific modalities deliberately invoked by any therapeutic system.
Role of a New Intimin/Invasin-Like Protein in Yersinia pestis Virulence

ABSTRACT A comprehensive TnphoA mutant library was constructed in Yersinia pestis KIM6 to identify surface proteins involved in Y. pestis host cell invasion and bacterial virulence. Insertion site analysis of the library repeatedly identified a 9,042-bp chromosomal gene (YPO3944), intimin/invasin-like protein (Ilp), similar to the Gram-negative intimin/invasin family of surface proteins. Deletion mutants of ilp were generated in Y. pestis strains KIM5(pCD1+) Pgm− (pigmentation negative)/, KIM6(pCD1−) Pgm+, and CO92. Comparative analyses were done with the deletions and the parental wild type for bacterial adhesion to and internalization by HEp-2 cells in vitro, infectivity and maintenance in the flea vector, and lethality in murine models of systemic and pneumonic plague. Deletion of ilp had no effect on bacterial blockage of flea blood feeding or colonization. The Y. pestis KIM5 Δilp strain had reduced adhesion to and internalization by HEp-2 cells compared to the parental wild-type strain (P < 0.05). Following intravenous challenge with Y. pestis KIM5 Δilp, mice had a delayed time to death and reduced dissemination to the lungs, livers, and kidneys as monitored by in vivo imaging using a lux reporter system (in vivo imaging system [IVIS]) and bacterial counts. Intranasal challenge in mice with Y. pestis CO92 Δilp had a 55-fold increase in the 50% lethal dose ([LD50] 1.64 × 104 CFU) compared to the parental wild-type strain LD50 (2.98 × 102 CFU). These findings identified Ilp as a novel virulence factor of Y. pestis.
Unsuccessful diagnostic cytogenetic analysis is a poor prognostic feature in acute myeloid leukaemia

Chromosome banding analysis is the gold standard method for the identification of recurrent cytogenetic abnormalities in acute myeloid leukaemia (AML). It allows stratification of AML patients into subgroups with distinct responses to therapy and survival. Unfortunately, a variety of issues hamper cytogenetic evaluation in c. 10% of cases [unsuccessful cytogenetics (UC)] and the outcome of these patients is poorly understood. To better define the significance of UC in patients with AML, we compared the baseline characteristics and the prognostic impact of 94 (6%) patients, whose standard metaphase analysis yielded unacceptable results, to the remaining 1403 AML patients with successful cytogenetic analysis treated on successive Southwestern Oncology Group protocols. The incidence of UC increased with age, with peak incidence in patients older than 60 years. These patients had a lower response rate to induction chemotherapy (complete remission rate of 43%) and dismal 5‐year survival rates (16%), which was especially poor in patients older than 60 years (<5%). The complete remission and survival rates were similar to those seen in patients with unfavourable karyotype. The early death rate was not increased. These results suggest that UC increases with age and predict for poor outcomes, similar to the outcomes of patients with unfavourable karyotype.
Personalized broadcasting in banyan-hypercube networks

The banyan-hypercube (BH) is one of the recently introduced hypercube-based interconnection networks. Due to the importance of communication in the overall system performance in a multiprocessing environment, this paper presents a near-optimal personalized broadcasting algorithm on the BHs. The analysis of this algorithm for both BHs and hypercubes is conducted for both single-port communication and multiple-port communication. We show that personalized broadcasting for both networks have the same communication time in the single-port mode. In multiple-port mode, the performance of the BH depends on its number of levels. When the number of levels is less than 4, the BHs outperform the hypercubes. However, the hypercubes have better performance than the BHs with large number of levels (>4). When the number of levels is equal to 4, both networks have the same performance.
New reasons for early use of MRI in stroke

Neurologists are familiar with MRI as T1-, T2-, and proton density–weighted images, and, recently, magnetic resonance angiography (MRA). Here, we draw attention to newer MRI methods—diffusion-weighted imaging (DWI) and perfusion imaging (PI)—that are unique among all imaging methods in their sensitivity to pathophysiologic changes underlying acute stroke. Documentation in clinical studies is now sufficiently compelling to warrant careful consideration of DWI and PI by all physicians who care for patients with acute stroke syndrome. Conventional MRI methods usually detect ischemic lesions after a few hours, well before clear changes appear on x-ray CT, and with much greater anatomic resolution. The increased sensitivity is particularly obvious in the posterior fossa, where imaging artifacts can mask acute CT changes. However, the advantages of MRI for stroke diagnosis have not yet been documented by clinical outcome studies comparing it directly with CT, which led Powers and Zivin to express well-reasoned reservations about whether MRI is so clearly superior as to justify the costs in money and procedural adjustment that its rapid general adoption would require.1 We believe that recent literature on DWI and PI has tipped the balance definitively in favor of accelerated implementation of MRI as the principal imaging modality for initial evaluation of acute stroke syndrome. This issue of Neurology contains two articles2,3 and a review4 providing new support for that position. Their independent submission to a single journal within a few weeks of each other accurately reflects the pace of development in the field. Diffusion-weighted imaging. Diffusion in liquids occurs by Brownian motion, the random process of molecular displacements caused by thermal agitation. DWI measures the diffusive motion of water molecules as an apparent diffusion coefficient (ADC), which varies with location in biologic tissue. The anatomic differences can be rendered as an image by standard …