Miracle-dz/UniFAR-FTUs huggingface dataset:
Electrostatic subframing and compressive-sensing video in transmission electron microscopy

We present kilohertz-scale video capture rates in a transmission electron microscope, using a camera normally limited to hertz-scale acquisition. An electrostatic deflector rasters a discrete array of images over a large camera, decoupling the acquisition time per subframe from the camera readout time. Total-variation regularization allows features in overlapping subframes to be correctly placed in each frame. Moreover, the system can be operated in a compressive-sensing video mode, whereby the deflections are performed in a known pseudorandom sequence. Compressive sensing in effect performs data compression before the readout, such that the video resulting from the reconstruction can have substantially more total pixels than that were read from the camera. This allows, for example, 100 frames of video to be encoded and reconstructed using only 15 captured subframes in a single camera exposure. We demonstrate experimental tests including laser-driven melting/dewetting, sintering, and grain coarsening of nanostructured gold, with reconstructed video rates up to 10 kHz. The results exemplify the power of the technique by showing that it can be used to study the fundamentally different temporal behavior for the three different physical processes. Both sintering and coarsening exhibited self-limiting behavior, whereby the process essentially stopped even while the heating laser continued to strike the material. We attribute this to changes in laser absorption and to processes inherent to thin-film coarsening. In contrast, the dewetting proceeded at a relatively uniform rate after an initial incubation time consistent with the establishment of a steady-state temperature profile.
Global Dynamics of Yeast Hsp90 Middle and C-Terminal Dimer Studied by Advanced Sampling Simulations

The Hsp90 protein complex is one of the most abundant molecular chaperone proteins that assists in folding of a variety of client proteins. During its functional cycle it undergoes large domain rearrangements coupled to the hydrolysis of ATP and association or dissociation of domain interfaces. In order to better understand the domain dynamics comparative Molecular Dynamics (MD) simulations of a sub-structure of Hsp90, the dimer formed by the middle (M) and C-terminal domain (C), were performed. Since this MC dimer lacks the ATP-binding N-domain it allows studying global motions decoupled from ATP binding and hydrolysis. Conventional (c)MD simulations starting from several different closed and open conformations resulted in only limited sampling of global motions. However, the application of a Hamiltonian Replica exchange (H-REMD) method based on the addition of a biasing potential extracted from a coarse-grained elastic network description of the system allowed much broader sampling of domain motions than the cMD simulations. With this multiscale approach it was possible to extract the main directions of global motions and to obtain insight into the molecular mechanism of the global structural transitions of the MC dimer.
Timing, distribution, and microbiology of infectious complications after necrotizing pancreatitis

BACKGROUND Acute pancreatitis (AP) is a common acute abdominal disease worldwide, and its incidence rate has increased annually. Approximately 20% of AP patients develop into necrotizing pancreatitis (NP), and 40% to 70% of NP patients have infectious complications, which usually indicate a worse prognosis. Infection is an important sign of complications in NP patients. AIM To investigate the difference in infection time, infection site, and infectious strain in NP patients with infectious complications. METHODS The clinical data of AP patients visiting the Department of General Surgery of Xuanwu Hospital of Capital Medical University from January 1, 2014 to December 31, 2018 were collected retrospectively. Enhanced computerized tomography or magnetic resonance imaging findings in patients with NP were included in the study. Statistical analysis of infectious bacteria, infection site, and infection time in NP patients with infectious complications was performed, because knowledge about pathogens and their antibiotic susceptibility patterns is essential for selecting an appropriate antibiotic. In addition, the factors that might influence the prognosis of patients were analyzed. RESULTS In this study, 539 strains of pathogenic bacteria were isolated from 162 patients with NP infection, including 212 strains from pancreatic infections and 327 strains from extrapancreatic infections. Gram-negative bacteria were the main infectious species, the most common of which were Escherichia coli and Pseudomonas aeruginosa. The extrapancreatic infection time (9.1 ± 8.8 d) was earlier than the pancreatic infection time (13.9 ± 12.3 d). Among NP patients with early extrapancreatic infection (< 14 d), bacteremia (25.12%) and respiratory tract infection (21.26%) were predominant. Among NP patients with late extrapancreatic infection (> 14 d), bacteremia (15.94%), respiratory tract infection (7.74%), and urinary tract infection (7.71%) were predominant. Drug sensitivity analysis showed that P. aeruginosa was sensitive to enzymatic penicillins, third- and fourth-generation cephalosporins, and carbapenems. Acinetobacter baumannii and Klebsiella pneumoniae were sensitive only to tigecycline; Staphylococcus epidermidis and Enterococcus faecium were highly sensitive to linezolid, tigecycline, and vancomycin. CONCLUSION In this study, we identified the timing, the common species, and site of infection in patients with NP.
A Global Optimizer for Nanoclusters

We have developed an algorithm to automatically build the global minimum and other low-energy minima of nanoclusters. This method is implemented in PyAR (https://github.com/anooplab/pyar) program. The global optimization in PyAR involves two parts, generation of several trial geometries and gradient-based local optimization of the trial geometries. While generating the trial geometries, a Tabu list is used for storing the information of the already used trial geometries to avoid using the similar trial geometries. In this recursive algorithm, an n-sized cluster is built from the geometries of n−1 clusters. The overall procedure automatically generates many unique minimum energy geometries of clusters with size from 2 up to n using this evolutionary growth strategy. We have used our strategy on some of the well-studied clusters such as Pd, Pt, Au, and Al homometallic clusters, Ru-Pt and Au-Pt binary clusters, and Ag-Au-Pt ternary cluster. We have analyzed some of the popular parameters to characterize the clusters, such as relative energy, singlet-triplet energy difference, binding energy, second-order energy difference, and mixing energy, and compared with the reported properties.
Me Too: Does Workplace Sexual Harassment Hurt Firm Value?

We investigate the impact of workplace sexual harassment on firm value by estimating the incidence of sexual harassment (SH) through textual analysis of online job reviews. During 2011-2017, the value-weighted portfolio of firms in the top quantiles (top 1% to 5%) of the SH score earned a four-factor annualized alpha ranging from –7.5% to –13.8%, representing an annual shareholder value loss of $0.8 to $1.4 billion per harassment-prone firm. High SH scores are also associated with sharp declines in operating profitability and increases in labor costs. These results indicate that sexual harassment has a highly detrimental effect on firm value.
LIVING IN THE LAND : AN OIKO-THEOLOGICAL RESPONSE TO THE AMADIBA CRISIS COMMITTEE OF XOLOBENI’S STRUGGLE FOR UBUNTU, LAND AND ECOLOGY

The central thesis of this article is that the network of living relationships between community, ecology and land as understood by the Amadiba people of Xolobeni may be recognised as an integral part of the wider context in which public and ecumenical oikos- and ubuntu theology needs to be practiced, in a challenging time in South African society is dealing with serious challenges regarding mining, land, economic development and communities’ struggle to control their own livelihoods and destinies. As part of this article, the story of the Amadiba Crisis Committee’s struggle to say no against brutal mining and road development is told. This leads to the searching for some pointers for public oiko-ubuntu theologians to participate in the struggle for human rights and self-determination for communities threatened by mining. These are, i) a contextual analysis of government’s engagement with ecology and economy from perspective of the oikonomia tou Theou (the economy of God); ii) ecumenical cooperation with the groundswell of community organisations and ngo’s who are working for justice for mining-affected communities; iii) and possible ways of keeping government accountable to communities.
2-Deoxyglucose and Newcastle Disease Virus Synergize to Kill Breast Cancer Cells by Inhibition of Glycolysis Pathway Through Glyceraldehyde3-Phosphate Downregulation

Targeting cancer cells metabolism is promising strategy in inhibiting cancer cells progression that are known to exhibit increased aerobic glycolysis. We used the glucose analog 2-Deoxyglucose (2-DG) as a competitor molecule of glucose. To further enhance the effectiveness of 2-DG, the Newcastle disease virus (NDV) was used as a combination virotherapy to enhance the anti-tumor effect. Human and mouse-breast cancer cells were treated by NDV and/or 2-DG. The effect was analyzed by study cell viability, apoptosis and level of glyceraldehyde3-phosphate (GAPDH) by ELISA and QPCR assays. Synergistic cytotoxicity was found after a 72-h treatment of human- and mouse-breast cancer cells with 2-DG in combination with NDV at different concentrations. The synergistic cytotoxicity was accompanied by apoptotic cell death and GAPDH downregulation and inhibition to glycolysis product pyruvate. The combination treatment showed significant tumor growth inhibition compared to single treatments in vivo. Our results suggest the effectiveness of a novel strategy for anti-breast cancer therapy through glycolysis inhibition and GAPDH downregulation.
THE INFLUENCE OF LEADERSHIP STYLE ON SERVICE QUALITY IN HIGHER EDUCATION: A STUDY AT A SOCIAL SCIENCE FACULTY

This study aimed at disclosing the influence of the leadership style on the service quality in Higher Education Institution. This study population is 103 supporting staffs of a social science faculty, with a proportional random sampling of 80 people. The hypothesis in this study was analyzed by using the structural model of Partial Least Square.Based on the results of Partial Least Square testing, it is disclosed that there is a significant influence of the leadership style on the service quality at the faculty being studied. The positive correlation shows that the stronger the leadership style is, the higher the leadership style impact on the service quality will be.
Haemorrhagic and thrombotic diseases

Practical Hemostasis and Thrombosis-Nigel S. Key 2017-01-17 Designed as a practical, succinct guide, for quick reference by clinicians with everyday questions, this title guides the reader through the range of approaches available for diagnosis, management, or prevention of hemorrhagic and thrombotic diseases or disorders. Provides essential practical management for all those working in the field of hemostasis and thrombosis Includes new chapters on direct oral anticoagulants, acquired inhibitors of coagulation, and expanded discussion of thrombotic microangiopathies Covers in a clear and succinct format, the diagnosis, treatment and prevention of thrombotic and haemostatic disorders Follows templated chapter formats for rapid referral, including key points and summary boxes, and further reading Highlights controversial issues and provides advice for everyday questions encountered in the clinic
Personal Perception and Attitude of Adult People towards Health at Meherpur Town, Bangladesh

Medical treatments or lifestyle choices are not the only factors that shape the health of people. Personal perception about health status and positive health attitude is very important to maintain sound health. This study aims at shedding light on personal perception of obesity status and attitude of adult people towards health at Meherpur town, Bangladesh. Both bivariate and multivariate analyses have been incorporated in this study using a total of 200 samples. Results indicate that most of the respondents were lacking pr.oper knowledge on their health status and majority were indifferent towards maintenance of proper health. About 80.5 percent of the respondents were normal weight and only about 0.5 percent was obese, but only about 22.5 percent knew their obesity status correctly. Respondents with secondary and higher education and respondents with income level BOT 10,000 and above were more likely to undergo health checkup and spend medium and high amount on health than that of their counterparts. There also remains a noticeable gap between the respondents of centre and outskirts in terms of undertaking health checkup and health expenditure. This article deduces that Respondents' education, income and living area are very important covariates of health attitude.
Methane Production and Bioactivity-A Link to Oxido-Reductive Stress

Biological methane formation is associated with anoxic environments and the activity of anaerobic prokaryotes (Archaea). However, recent studies have confirmed methane release from eukaryotes, including plants, fungi, and animals, even in the absence of microbes and in the presence of oxygen. Furthermore, it was found that aerobic methane emission in plants is stimulated by a variety of environmental stress factors, leading to reactive oxygen species (ROS) generation. Further research presented evidence that molecules with sulfur and nitrogen bonded methyl groups such as methionine or choline are carbon precursors of aerobic methane formation. Once generated, methane is widely considered to be physiologically inert in eukaryotes, but several studies have found association between mammalian methanogenesis and gastrointestinal (GI) motility changes. In addition, a number of recent reports demonstrated anti-inflammatory potential for exogenous methane-based approaches in model anoxia-reoxygenation experiments. It has also been convincingly demonstrated that methane can influence the downstream effectors of transiently increased ROS levels, including mitochondria-related pro-apoptotic pathways during ischemia-reperfusion (IR) conditions. Besides, exogenous methane can modify the outcome of gasotransmitter-mediated events in plants, and it appears that similar mechanism might be active in mammals as well. This review summarizes the relevant literature on methane-producing processes in eukaryotes, and the available results that underscore its bioactivity. The current evidences suggest that methane liberation and biological effectiveness are both linked to cellular redox regulation. The data collectively imply that exogenous methane influences the regulatory mechanisms and signaling pathways involved in oxidative and nitrosative stress responses, which suggests a modulator role for methane in hypoxia-linked pathologies.
Neural Correlates of Facial Expression Recognition in Earthquake Witnesses

Major adverse events, like an earthquake, trigger different kinds of emotional dysfunctions or psychiatric disorders in the exposed subjects. Recent literature has also shown that exposure to natural disasters can increase threat detection. In particular, we previously found a selective enhancement in the ability to read emotional facial expressions in L’Aquila earthquake witnesses, suggesting hypervigilance to stimuli signaling a threat. In light of previous neuroimaging data showing that trauma exposure is related to derangement of resting-state brain activity, in the present study we investigated the neurofunctional changes related to the recognition of emotional faces in L’Aquila earthquake witnesses. Specifically, we tested the relationships between accuracy in recognizing facial expressions and activity of the visual network (VN) and of the default-mode network (DMN). Resting-state functional connectivity (FC) with the main hub of the VN (primary, ventral, right-dorsal, and left-dorsal visual cortices) and DMN (posterior cingulate/precuneus, medial prefrontal, and right and left inferior parietal cortices) was investigated through a seed-based functional magnetic resonance imaging (fMRI) analysis in both earthquake-exposed subjects and non-exposed persons who did not live in an earthquake-affected area. The results showed that, in earthquake-exposed subjects, there is a significant reduction in the correlation between accuracy in recognizing facial expressions and the FC of the dorsal seed of the VN with the right inferior occipito-temporal cortex and the left lateral temporal cortex, and of two parietal seeds of DMN, i.e., lower parietal and medial prefrontal cortex, with the precuneus bilaterally. These findings suggest that a functional modification of brain systems involved in detecting and interpreting emotional faces may represent the neurophysiological basis of the specific “emotional expertise” observed in the earthquake witnesses.
Discussion of the relationship between perceived job characteristics and organizational commitment of university PE teachers-from the aspect of job stress

Abstract This study aims to discuss the current conditions and relations between university PE teachers’ perceived job characteristics and organizational commitment as well as the predictability of university PE teachers’ perceived job characteristics on organizational commitment. Taking university PE teachers in Jiangsu and Zhejiang area, China, as the research objects, questionnaire survey is used for discussing the relations among university PE teachers’ job stress, perceived job characteristics, and organizational commitment. With Stratified Random Sampling, total 500 copies of questionnaire are distributed and 395 valid copies are retrieved. The Multiple Stepwise Regression Analysis results show the significantly positive relations between job characteristics and organizational commitment, the remarkably positive relations between job characteristics and job stress, and partial mediation effects of job stress on the relations between job characteristics and organizational commitment. Suggestions for relevant policies are therefore proposed for the reference of relative units and successive research.
A Traffic Flow Prediction Method Based on Road Crossing Vector Coding and a Bidirectional Recursive Neural Network

Aiming at the problems that current predicting models are incapable of extracting the inner rule of the traffic flow sequence in traffic big data, and unable to make full use of the spatio-temporal relationship of the traffic flow to improve the accuracy of prediction, a Bi-directional Regression Neural Network (BRNN) is proposed in this paper, which can fully apply the context information of road intersections both in the past and the future to predict the traffic volume, and further to make up the deficiency that the current models can only predict the next-moment output according to the time series information in the previous moment. Meanwhile, a vectorized code to screen out the intersections related to the predicting point in the road network and to train and predict through inputting the track data of the selected intersections into BRNN, is designed. In addition, the model is testified through the true traffic data in partial area of Shen Zhen. The results indicate that, compared with current traffic predicting models, the model in this paper is capable of providing the necessary evidence for traffic guidance and control due to its excellent performance in extracting the spatio-temporal feature of the traffic flow series, which can enhance the accuracy by 16.298% on average.
Instructor Experiences Designing MOOCs in Higher Education: Pedagogical, Resource, and Logistical Considerations and Challenges.

As massive open online courses (MOOCs) increase, the large scale and heterogeneity of MOOC participants bring myriad significant design challenges. This exploratory mixed methods study explores 143 MOOC instructors’ considerations and challenges in designing MOOCs, 12 of whom were interviewed and had their courses analyzed. The survey, interview, and course review data revealed a variety of considerations and challenges in MOOC design in terms of pedagogy, resources, and logistics. Pedagogical considerations included learning objectives, assessment methods, course length, course content, flexibility, and collaborative learning support. Resource considerations included the affordance of MOOC platforms, support from the host institution and the platform, and the available intellectual and hardware resources. Logistical considerations included the amount of time instructors spent designing the MOOC. The obstacles included pedagogical challenges (e.g., engaging learners, increasing learner interaction, and limited assessment methods), resource challenges (e.g., limitations associated with the affordances of the platform), and logistical challenges (e.g., time limitations for designing and developing MOOCs). To address these challenges, the instructors often relied on reviewing other MOOCs. They also sought help from colleagues, their universities, and support personnel of the adopted platforms.
The frontline of social prescribing – How do we ensure Link Workers can work safely and effectively within primary care?

Objective To identify the training, skills and experience social prescribing Link Workers, working with patients presenting with long-term conditions, need to carry out their role safely and effectively within primary care services. Method Qualitative data were collected from Link Workers as part of the evaluation of three social prescribing schemes. Interviews and focus groups were audio-recorded and transcribed. Results Link Workers describe the complexity of the work and the need to define the boundaries of their role within existing services. Previous life and work experience were invaluable and empathy was seen as a key skill. A variety of training was valued with counselling skills felt to be most critical. Clinical supervision and support were felt to be essential to conduct the work safely. Discussion Social prescribing is a significant theme within UK health policy and internationally and schemes in primary care services are common. Patient accounts consistently suggest that the Link Worker is key to the success of the pathway. Link Workers can facilitate positive behaviour change; however they must be recruited, trained and supported with a clear understanding of the demands of this complex role.