Miracle-dz/UniFAR-FTUs huggingface dataset:
Omni-Plus-Seven (O 7 + ): An Omnidirectional Aerial Prototype with Minimal Uni-directional Thrusters

—The aim of this paper is to present the design of a novel omnidirectional Unmanned Aerial Vehicle (UAV) with seven uni-directional thrusters, called O 7 + . The paper formally deﬁnes the O + design for a generic number of propellers and presents its necessary conditions; then it illustrates a method to optimize the placement and orientation of the platform’s propellers to achieve a balanced O + design. The paper then details the choice of the parameters of the O 7 + UAV, and highlights the required mechanical and electrical components. The resultant platform is tested in simulation, before being implemented as a prototype. The prototype is ﬁrstly static-bench tested to match its nominal and physical models, followed by hovering tests in multiple orientations. The presented prototype shows the ability to ﬂy horizontally, upside down and at a tilted angle.
Characterization of eggshell as a bio-regeneration material

Objective The objective of this study was to identify and summarize the characteristic features of eggshell for regeneration purpose in oral surgery procedures. Methods A review of literature was undertaken based on the PubMed database. A search to reveal the current state of knowledge and the current uses of the eggshell as a biomaterial was performed. The characteristics of the materials, the specific use, the procedure and the outcome were extracted from the articles. Results The materials have been found to be used in humans, animals, and in vitro studies. There is a wide use regarding oral surgery especially in experimental models. There have also been attempts to enhance certain properties and improve the capabilities of eggshell as a biomaterial. There is yet a commercial product to be developed and approved for human use. Conclusions Eggshell can be an important biowaste which can be of use in guided bone regeneration procedures, but it has not yet entered the commercial phase and approval through official regulation channels.
Theorising Health System Resilience and the Role of Government Policy- Challenges and Future Directions

Resilient healthcare (RHC) emphasises the importance of adaptive capacity to respond to unanticipated crises such as the global coronavirus disease 2019 (COVID-19) pandemic but there are few examples of RHC research focusing on the decisions taken by macro level policy makers. The Smaggus et al paper analyses the actions of two governments in Canada and Australia as described in media releases from a resilience perspective. The paper clearly articulates the need for conceptual clarity when analysing system resilience, and integrates three theoretical perspectives to understand the types of government responses and how they were related to resilience. The paper makes a valuable contribution to the developing RHC evidence base, but challenges remain in identifying conceptual frameworks, researching macro level resilience, including identifying and accessing reliable macro level data sources, analysing interactions between macro, meso and micro system levels, and understanding how resilience manifests at different temporal and spatial scales.
Variability Driven Quality Evaluation in Software Product Lines

Variability is a key aspect in software product lines. Functional variability has been largely studied as a way to obtain all the desired products for a line. Quality variability, less understood and more complex, has not received so much attention by researchers. However, different members of the line may require different levels of a quality attribute. The design phase is a good point to assure that quality attributes requirements are met within the product line so this means paying attention to software architecture evaluation during domain engineering. The quality evaluation in software product lines is much more complicated than in single-systems as products can require different quality levels and the product line can have variability on design that in turn affects quality. The evaluation of all the products of a line is very expensive. Thus, ways of reducing the evaluation efforts are necessary. Herein is presented a method for facilitating cost-effective quality evaluation of a product line taking into consideration variability on quality attributes.
Importance of silicon in combating a variety of stresses in plants: A review

The abundance of silicon (Si) in the earth's crust is found as silicon dioxide (SiO2). But this abundance of Si is not a sign that the plants take up an adequate amount of Si. This review article incorporates research based on Si to understand the importance of Si in plants under various stress conditions and its role in sustainable agricultural production. Si's application is considered a better approach to providing stress tolerance to plants under stress conditions. The review describes the different phases of Si, its absorption, transport in plants, and its various mechanisms of action to tolerate specific stresses. The uptake and transport of Si through various Si transporters have also been reported. This review also discusses the various mechanisms of Si under biotic or abiotic stress in different plants. The application of Si improves soil quality and soil health and enhances the soil microbial population. In addition, the role of Si in the upregulation and down-regulation of proteins under stressful conditions has also been reported. The information can help to better understand the importance and mechanism of Si in plants and its application in agriculture.
Intercellular Adhesion Molecule-1 Enhances Myonuclear Transcription during Injury-Induced Muscle Regeneration

The local inflammatory environment of injured skeletal muscle contributes to the resolution of the injury by promoting the proliferation of muscle precursor cells during the initial stage of muscle regeneration. However, little is known about the extent to which the inflammatory response influences the later stages of regeneration when newly formed (regenerating myofibers) are accumulating myonuclei and undergoing hypertrophy. Our prior work indicated that the inflammatory molecule ICAM-1 facilitates regenerating myofiber hypertrophy through a process involving myonuclear positioning and/or transcription. The present study tested the hypothesis that ICAM-1 enhances global transcription within regenerating myofibers by augmenting the transcriptional activity of myonuclei positioned in linear arrays (nuclear chains). We found that transcription in regenerating myofibers was ~2-fold higher in wild type compared with ICAM-1-/- mice at 14 and 28 days post-injury. This occurred because the transcriptional activity of individual myonuclei in nuclei chains, nuclear clusters, and a peripheral location were ~2-fold higher in wild type compared with ICAM-1-/- mice during regeneration. ICAM-1’s enhancement of transcription in nuclear chains appears to be an important driver of myofiber hypertrophy as it was statistically associated with an increase in myofiber size during regeneration. Taken together, our findings indicate that ICAM-1 facilitates myofiber hypertrophy after injury by enhancing myonuclear transcription.
Adapting to The Pandemic COVID-19: Smart City Implementation in Blitar City

: COVID-19 seriously hitting most countries worldwide is an alarming issue affecting the mindset of the Indonesian government. Many studies have revealed that the outbreak has forced the government to make some adjustments by seeking smart solutions that are effective and efficient for public services, which has brought the government to the concept of a smart city. Departing from this background, this research aims to investigate how Blitar City is struggling to adapt to the situation by adjusting to the Smart City implementation. This research found that, guided by qualitative research methodology and the Smart City theoretical framework, the desire for changes in terms of public services from citizens is relatively high. However, the lack of a legal basis for the smart city in Blitar City seems to hinder the objective. Furthermore, there is a vague understanding of the concept that is hampered by some local agencies (Dinas) and civil servants. Therefore, local regulation relating to the concept is required to ensure the implementation of smart cities in Blitar City. The Readiness of all actors in Blitar City also needs upgrading in order to maintain the long-term Smart City implementation at a local level.
Immunotherapy in NSCLC Patients with Brain Metastases

Approximately 40% of unselected non-small cell lung cancer (NSCLC) patients develop brain metastases (BMs) during their disease, with considerable morbidity and mortality. The management of BMs in patients with NSCLC is a clinical challenge and requires a multidisciplinary approach to gain effective intracranial disease control. Over the last decade, immune checkpoint inhibitors (ICIs) have emerged as a game-changer in the treatment landscape of advanced NSCLC, with significant improvements in survival outcomes, although patients with BMs are mostly underrepresented in randomized clinical trials. Moreover, the safety and activity of ICIs and radiotherapy combinations compared with single-agent or sequential modalities is still under evaluation to establish the optimal management of these patients. The aim of this review is to summarize the state-of-the-art of clinical evidence of ICIs intracranial activity and the main challenges of incorporating these agents in the treatment armamentarium of NSCLC patients with BMs.
Magnoliae flos Downregulated Lipopolysaccharide-Induced Inflammatory Responses via NF-κB/ERK-JNK MAPK/STAT3 Pathways

Background Magnoliae flos is the dried flower bud of Magnolia biondii and related plants. It has been used as a medicinal herb for the treatment of rhinitis, sinusitis, and sinus headaches. Nevertheless, the effects of Magnoliae flos in microbial infection or sepsis remain unclear. In this study, we investigated the anti-inflammatory effects of Magnoliae flos water extract (MF) in lipopolysaccharide- (LPS-) induced septic mice and LPS-stimulated RAW264.7 macrophages. Results We found that MF reduced the mortality of LPS-challenged mice. Enzyme immunoassays and reverse transcription polymerase chain reaction analysis revealed that MF administration attenuated mRNA expression and protein production of proinflammatory mediators, including cyclooxygenase 2, inducible nitric oxide synthase, tumor necrosis factor-α, and interleukin-6. In parallel to these results in mice, pretreatment with MF suppressed the LPS-induced production of proinflammatory mediators in RAW264.7 macrophages. In addition, we found that MF exerted its suppressive effects by inhibiting the activation of the mitogen-activated protein kinase, nuclear factor-κB, and signal transducer and activator of transcription pathways at the protein level. Conclusion MF could be a potential therapeutic agent for regulating excessive inflammatory responses in sepsis.
Co-valorization of Tuff and Sandy Residues in Roads Construction

In recent years, the use of local materials in pavements has developed to compensate for the lack of normalized standard materials in the Algerian arid regions. The main objective of this research is to assess the co-valorization of two local materials to design a road material with satisfactory characteristics. In this context, the use of tuff in combination with sand residues is explored. The evolution of the characteristics of tuffs mixed with sand residues according to percentages ranging from 0% to 50% is highlighted. The used materials were subjected to physical and mechanical tests. Then, a series of mechanical tests were carried out on mixed samples compacted at the optimal characteristics that were deduced from the modified Proctor test. The obtained results highlight the existence of an optimal formulation composed of 70% tuff and 30% sandy residues, which presented an unconfined compressive strength (UCS) of 5.16 MPs and a CBR index (CBRI) of 42.6 %. Moreover, the results show clearly the evolution of the measured characteristics with time (drying) and without the addition of binders. The possibility of the use of studied mixtures in pavements has been verified regarding the recommendations in use (CTTP 2001) and the Saharan Road Technique (SRT). Doi: 10.28991/CEJ-2022-08-05-013 Full Text: PDF
Adopting BuddyPress Platform as an Online Community of Practice for Professional Development

A community of practice can be formed to adopt professional development programs for teachers, according to the researcher’s experience in Saudi Arabia. A community of practice is a group of people who share common interests, values, and goals. Thus, the absence of research encouraged this study. It is an investigation of how the theory of online CoP mediates between teachers with common interests and specialists. Teachers class teaches the value of realistic practice and real-life examples. Like other professional development programs such as workshops or training, we observe how this can help employees establish their own identity. This article highlights the value of establishing a community of practice among teachers or others with similar interests. This method increases teacher enthusiasm, creativity, and idea exchange by broadening professional dialogue.
Food, not the photoperiod, entrains the circadian rhythms in the liver of Winstar albino rats

The central oscillator is located in mammals' suprachiasmatic nucleus (SCN). The liver is the non-photic organ and the centre for metabolic activities. Food could be a potential zeitgeber for the liver as the timing of feeding is precise in animals. The present study hypothesized that the food provided at a different time of the day (consistently delay of 6 hours) could lead to the desynchronization of daily rhythms in clock genes in liver tissues. The Winstar albino rats were divided into three groups and were exposed to a daily light-dark cycle (12L:12D; 12h light and 12h dark). The Group 1 (Control group) had food ad libitum, Group 2- second group- 6h food group had daily food availability of 6h (night fed group). In contrast, Group 3- T30 group was provided food for 6 hours but delayed by 6h from the previous day's food timing. After 30 days, animals were sacrificed at six-time points and the expression of clock genes was studied in the liver. Food cycle's effect was observed on body mass, and it was significantly (P < 0.05) reduced in the T30 group. The circadian clock persisted in both food ad libitum and night fed groups but changed in phase and amplitude. However, it lost daily rhythm in clock genes in liver tissues of the T30 group. These results are significant as they suggest that the food's timing is critical for synchronizing the circadian clock in the metabolic center, i.e., the liver.
COVID-19 Vaccination Campaign among the Health Workers of Fondazione Policlinico Universitario Agostino Gemelli IRCCS: A Cost–Benefit Analysis

Vaccinations generate health, economic and social benefits in both vaccinated and unvaccinated populations. The aim of this study was to conduct a cost–benefit analysis to estimate the costs and benefits associated with the COVID-19 vaccination campaign for health workers in Fondazione Policlinico Universitario Agostino Gemelli IRCCS (FPG). The analysis included 5152 healthcare workers who voluntarily received the Pfizer–BioNTech COVID-19 vaccine, divided into physicians, nurses and other health workers. Data about vaccine cost, administration and materials were derived from administrative databases of the FPG from 28 December 2020 to 31 March 2021. The costs associated with the COVID-19 vaccination campaign amounted to EUR 2,221,768, while the benefits equaled EUR 10,345,847. The benefit-to-cost ratio resulted in EUR 4.66, while the societal return on investment showed a ratio of EUR 3.66. The COVID-19 vaccination campaign for health workers in FPG has high social returns and it strengthens the need to inform and update decision-making about the economic and social benefits associated with a vaccination campaign. Health economic evaluations on vaccines should always be considered by decision-makers when considering the inclusion of a new vaccine into the national program.
Predictors of Adherence and Asthma Control in Two Federal Teaching Hospitals in Nigeria

Asthma is a common chronic disease in developing countries. The main objective of the study was to provide insights into adherence and asthma control predictors in two federal teaching hospitals in Nigeria, using validated instruments. For the data analysis, the level of statistical significance was set as p < 0.05. Seventy-eight patients with asthma provided consent for study participation. Every time domestic fuel was utilized at home, asthma control decreased by 1.246 units, p = 0.029. Every time an asthma patient utilized one of the hospitals which did not have a separate Asthma Clinic, adherence decreased by 1.483 units, p < 0.001. The study reveals the need for patients with asthma to minimize the use of domestic fuel. Renewable energy sources could be considered. A separate Asthma Clinic can provide ample time for asthma reviews. Dhaka Univ. J. Pharm. Sci. 21(1): 45-51, 2022 (June)
A Malicious Domain Detection Model Based on Improved Deep Learning

With the rapid development of the Internet, malicious domain names pose more and more serious threats to many fields, such as network security and social security, and there have been many research results on malicious domain detection. This article proposes a malicious domain name detection model based on improved deep learning, which can combine the advantages of three different network models, convolutional neural network (CNN), temporal convolutional network (TCN), and long short-term memory network (LSTM) in malicious domain name detection, to obtain a better detection effect than that of the original single or two models. Experiments show that the effect of the improved deep learning model proposed in this article is better than that of the combined model of CNN and LSTM or the combined model of CNN and TCN, and the accuracy and regression rates reached 99.76% and 98.81%, respectively.
National forestry policy

Well over sixty years ago the current pattern of land development was well defined. Already the land hunger of the pioneers had exhausted all the arable fertile flat lands of the Dominion. These had carried dense stands of the best indigenous softwoods of which probably 90% were sacrificed to the fire stick and only 10% usefully converted into sawn timber, fencing posts, etc.
The Neurobiological Basis of Love: A Meta-Analysis of Human Functional Neuroimaging Studies of Maternal and Passionate Love

Maternal and passionate love are both crucial for reproduction and involve attachment behaviors with high rewards. Neurobiological studies of attachment in animal and human neuroimaging studies have suggested that the coordination of oxytocinergic and vasopressinergic pathways, coupled with the dopaminergic reward system, contribute to the formation and maintenance of maternal and passionate love. In the present study, we carried out a quantitative meta-analysis of human neuroimaging to identify common and dissociable neural substrates associated with maternal and passionate love, using the activation likelihood estimation (ALE) approach. The ALE results showed significant activation of the brain regions in the left ventral tegmental area (VTA), right thalamus, left substantia nigra, and the left putamen for maternal love, but in the bilateral VTA for passionate love. The meta-analytic neuroimaging evidence suggests the greater involvement of cognitive–affective regulation in maternal attachment and the greater desire to combine liking and wanting in romantic love behaviors. The conjunction analysis highlights the functional convergence of the VTA across the two types of human love, indicating a shared neurobiological mechanism of maternal and passionate love with evolutionary roots. Our findings suggest that the processing of both maternal and passionate love involve the affective and motivational regulation associated with dopaminergic systems; our neuroimaging evidence supports the notion that maternal and passionate love share a common evolutionary origin and neurobiological basis in the human brain.
Health Risk Assessment of Heavy Metals in Groundwater of Hainan Island Using the Monte Carlo Simulation Coupled with the APCS/MLR Model

Groundwater is a significant component of water resources, but drinking groundwater with excessive heavy metals (HMs) is harmful to human health. Currently, quantitative source apportionment and probabilistic health risk assessment of HMs in groundwater are relatively limited. In this study, 60 groundwater samples containing seven HMs were collected from Hainan Island and analyzed by the coupled absolute principal component scores/multiple linear regression (APCS/MLR), the health risk assessment (HRA) and the Monte Carlo simulation (MCS) to quantify the pollution sources of HMs and the health risks. The results show that the high-pollution-value areas of HMs are mainly located in the industry-oriented western region, but the pollution level by HMs in the groundwater in the study area is generally low. The main sources of HMs in the groundwater are found to be the mixed sources of agricultural activities and traffic emissions (39.16%), industrial activities (25.57%) and natural sources (35.27%). Although the non-carcinogenic risks for adults and children are negligible, the carcinogenic risks are at a high level. Through analyzing the relationship between HMs, pollution sources, and health risks, natural sources contribute the most to the health risks, and Cr is determined as the priority control HM. This study emphasizes the importance of quantitative evaluation of the HM pollution sources and probabilistic health risk assessment, which provides an essential basis for water pollution prevention and control in Hainan Island.