Miracle-dz/UniFAR-FTUs huggingface dataset:
Planar cell polarity in the C. elegans embryo emerges by differential retention of aPARs at cell-cell contacts

Formation of the anteroposterior and dorsoventral body axis in the Caenorhabditis elegans embryo depends on cortical actomyosin flows and advection of polarity determinants. The role of this patterning mechanism in tissue polarization immediately after formation of cell-cell contacts is not fully understood. Here, we demonstrate that planar cell polarity (PCP) is established in the C. elegans embryo at the time of left-right (l/r) symmetry breaking. At this stage, centripetal cortical flows asymmetrically and differentially advect anterior polarity determinants (aPARs) PAR-3, PAR-6 and PKC-3 from cell-cell contacts to the medial cortex, which results in their unmixing from apical myosin. Advection generally requires GSK-3 and CDC-42, while advection of PAR-6 specifically depends on the RhoGAP PAC-1. Concurrent asymmetric retention of PAR-3, E-cadherin/HMR-1, PAC-1 and opposing retention of the antagonistic Wnt pathway components APC/APR-1 and Frizzled/MOM-5 at apical cell-cell contacts leads to planar asymmetries. The most obvious mark of PCP, asymmetric retention of PAR-3 at posterior cell-cell contacts on the left side of the embryo, is required for proper cytokinetic cell intercalation. Hence, our data uncover how PCP can be established through Wnt signaling as well as dissociation and planar asymmetric retention of aPARs mediated by distinct Rho GTPases and their regulators.
Aesthetic preferences of laypersons and its relationship with the conceptual properties on building façade design

ABSTRACT This article investigates the differences in aesthetic preferences on external facades on non-architects. A combination of a card sorting technique, a semi-structured interview, and a Mind sketching technique is employed. Data analysis was carried out using the qualitative techniques of content analysis. Findings reveal that non-architects were able to identify what they like and dislike regarding their preferences on façade designs. It reveals that among the conceptual properties, Originality Meaningfulness, Clarity, Simplicity were the most used properties by non-architects. However, non-architects’ aesthetic preferences and their suggestions for change to the given facades were found to be inconsistent. It can be concluded that involving potential users in the architectural process must be assisted by a design professional. Graphical Abstract
Production of Bioethanol from Napier grass: Comparison in Pre-treatment and Fermentation Methods

Bioethanol as alternative renewable energy can be derived from lignocellulosic biomass. One of the potential biomass that can be used for bioethanol is Napier grass (Pennisetum purpureum Schumach). Napier grass has a high content of cellulose which can be utilized as a substrate for fermentation process. A better understanding of bioconversion of Napier grass into bioethanol is essential for enhancing its performance. In this study, three biological agents were involved, Aspergillus niger and Phanerochaete chrysosporium for delignification and Neurospora sitophila for cellulase and bioethanol production in solid-state and submerged fermentation. Alkaline pretreatment using Ca(OH)2 and NaOH were conducted in this study. The result showed biological pretreatment using Aspergillus niger gave a higher delignification yield compared to alkaline pretreatment. For cellulase production, solid-state fermentation resulted in a higher enzyme activity compared to submerged fermentation and for bioethanol production, submerged fermentation yielded higher bioethanol compared to solid-state fermentation system but the difference was not too significant.
Jesus’ Use of Experiential Learning in the Sending of the Seventy: Implications for Ministry Practicums

Among His many teaching techniques, Jesus used experiential learning to link the disciples’ previous knowledge with real-world experiences. This article explores Jesus’ teaching techniques in the sending of the seventy(two) into Samaritan territory (Lk. 10:1-17). We discuss Jesus’ andragogical methods in light of current experiential learning theories, especially the Joplin-Linhart model. Last, we describe how church leaders could leverage the lessons from Jesus’ use of “practicums” to help Christians reflect on their own ministry experiences.
Entrepreneurial learning from failure. A systematic review

PurposeFailure plays a pivotal role in entrepreneurial learning. Knowledge of the learning process that enables an entrepreneur to re-emerge stronger after a failure, though considerable, is fragmented. This paper systematically collects relevant literature, assigns it to the stages of the experiential learning process (concrete experience, reflective observation, abstract conceptualization, active experimentation; Kolb, 1984), evaluates the research coverage of each stage and identifies promising avenues for future research.Design/methodology/approachThis systematic literature review follows the guidelines articulated by Short (2009) and Tranfieldet al.(2003), using Web of Science and EBSCO as primary data sources. Kolb’s (1984) experiential learning theory provides a basis for organizing the identified material into a framework of entrepreneurial learning from failure.FindingsThe literature provides insights on all stages of the process of entrepreneurial learning from failure. Particularly well elaborated are the nature of failure and its triggering effect for reflection, the factors influencing reflection, the contents of the resulting learning and their application in entrepreneurial re-emergence. Other topics remain under-researched, including alternative modes of recovery, the impact of personal attributes upon reflection, the cognitive processes underlying reflection, the transformation of failure-based observations into logically sound concepts and the application of this learning in non-entrepreneurial contexts.Originality/valueThis review provides the most complete overview of research into the process of entrepreneurial learning from failure. The systematic, theory-based mapping of this literature takes stock of current knowledge and proposes areas for future research.
Assessing smoke toxicity of burning combustibles by four expressions for fractional effective dose

Toxicity of smoke generated in a fire is difficult to measure accurately. That is because gas sensors for measuring rapidly varying concentrations of toxic gases are not yet developed. Simple expressions are searched for quick measurement in assessing smoke toxicity practically. Four equations on calculating fractional effective dose (FED) related to toxic effluents were reported in the literature, each based on different assumptions. FED value was proposed to be calculated based on peak carbon monoxide concentration and peak carbon dioxide concentration, and transient carbon monoxide, carbon dioxide, and oxygen concentrations. The four values were compared in this article using literature data on toxic gases from different materials measured by (i) cone calorimeter; (ii) full‐scale burning tests; and (iii) tunnel full‐scale tests. Measured carbon monoxide, carbon dioxide, and oxygen concentrations by standard equipment of oxygen consumption calorimeters were used to calculate the four FED values. It is found that the values of FED based on peak carbon monoxide and carbon dioxide concentrations (denoted as FED2) are similar to the average values of FED calculated from the updated equation in the literature using the oxygen consumption calorimeters. Putting the values of FED2 in fire safety design guides is then recommended.
Networks and Speed of Internationalization: A Multiple Case Study of Emerging Market IT Firms

Objective: This study aims to analyze the internationalization processes of two Brazilian IT firms from the perspective of business networks, seeking to understand the reasons that led these firms to internationalize, the factors influencing the process, and, above all, the importance of business networks. Method: a qualitative approach, based on multiple case study method was chosen. Main results: It was found that, although the firms internationalized for different reasons and in different ways, the propositions of the Network Theory, to a greater or lesser extent, were sufficiently robust to explain the internationalization processes of the two firms. Furthermore, in the case in which relationship networks played a more relevant role, the speed of internationalization was higher. Relevance / Originality: The present study addresses two literature gaps noted by Chetty and Stangl (2010): (i) the study of small and medium-sized enterprises in relation to internationalization, innovation, and networks; and (ii) the qualitative testing of the propositions raised by the authors on these subjects. Contributions: Both managerially – by stressing to managers and entrepreneurs the importance of relationship networks for the internationalization of firms, using real cases – and academically – by contributing to the literature on firm internationalization and network theory (NT).
Optimization of the parameters of the sewing thread cutting process

Процесите на рязане на нишки се използват широко в полуавтоматични машини за шивашката промишленост и представляват спешен проблем. Няма научно обоснована методология за проектиране на механизми за подрязване на нишки за полуавтоматични шевни машини. Рязането на нишки по метода на ножица не осигурява пълно рязане на всички компоненти на конеца в случай на недостатъчно притискане на равнините на ножа една към друга. За да се осигури цялостно подрязване, е разработена конструктивна схема за рязане и са получени формули за изчисление за определяне на силата, упражнена от нишката върху подвижния нож, като се вземат предвид механичните характеристики на нарязаната шевна нишка.
Smart Stress Annihilation in Steels Using Residual Stress Distribution Monitoring and Localized Induction Heating

The monitoring and control of residual stresses and microstructure are of paramount importance for the steel industry. Residual stress annihilation is needed during the entire lifetime of steels. In this paper, we presented a stress monitoring and annihilation method, based on a force sensor for stress monitoring and an induction heater for localized heat treatment and corresponding stress annihilation. The heat treatment results indicated an at least 90% reduction of localized stresses, allowing for the implementation of the method in steel production and manufacturing to improve steel quality and perform faultless steel production and manufacturing.
A Smart Framework for Mobile Botnet Detection Using Static Analysis

Botnets have become one of the most significant threats to Internet-connected smartphones. A botnet is a combination of infected devices communicating through a command server under the control of botmaster for malicious purposes. Nowadays, the number and variety of botnets attacks have increased drastically, especially on the Android platform. Severe network disruptions through massive coordinated attacks result in large financial and ethical losses. The increase in the number of botnet attacks brings the challenges for detection of harmful software. This study proposes a smart framework for mobile botnet detection using static analysis. This technique combines permissions, activities, broadcast receivers, background services, API and uses the machine-learning algorithm to detect mobile botnets applications. The prototype was implemented and used to validate the performance, accuracy, and scalability of the proposed framework by evaluating 3000 android applications. The obtained results show the proposed framework obtained 98.20% accuracy with a low 0.1140 false-positive rate.
Running Shoes—Possible Correlations of Biomechanical and Material Tests

Today’s development of running shoes is often supported by the assessment of biomechanical tests (BIOs) as well as material tests (MATs). In order to possibly reduce the number of relevant tests, the aim of this study was to find out whether there are correlations between the selected BIO and MATs. Therefore, four different running shoes were tested. For the BIO, the ground reaction force and tibial acceleration of 19 experienced runners were measured. The evaluated parameters were first peak, time to first peak, impulse during the first 75 ms of stance, maximum vertical ground reaction force, loading rate, mean peak acceleration and median power frequency. The MATs included compression tests and an impact test with and without insoles at the forefoot as well as the heel area. The results show that carrying out MATs (especially impact tests) without insoles give the most insight into the parameters analysed with the BIO.
Theoretical Study of Diels-Alder Reaction of But-3-en-2-one with Hexa-1,2,4-triene: A Density Functional Theory Study

The Diels-Alder reaction between but-3-en-2-one with hexa-1,2,4-triene was studied using density functional theory method at B3LYP-D3/6-311++G(d,p) level of theory. The geometries of the transition states were determined. Moreover, calculations of the vibrational frequencies permitted computation of the activation enthalpies and entropies. The computational results show that the cycloadducts from trans conformer have the lower relative energies (−46.48 and −47.50 kcal/mol) as compared to the cis conformer of cycloadducts (−44.45 and −45.87 kcal/mol). The global reactivity indices were analyzed at the ground state of reactants to predict the reactivity of the studied organic molecules in the cycloaddition reactions. The electronic chemical potential of hexa-1,2,4-trien found to be than but-3-en-2-one, which indicates that the net charge transfer will be from hexa-1,2,4-trien toward the electron-deficient but-3-en-2-one reactant.
Queering the periphery and challenging the center: Transgender students in Israeli higher education

Abstract This article discusses the experiences of Israeli trans students in higher education as a spatial phenomenon, demonstrating that their experiences are shaped by spatial locations – both geographic and cultural. Based on the thematic analysis of 20 in-depth interviews with Jewish Israeli transgender students from different spatial locations (‘central’ and ‘peripheral’ alike) and from varying academic fields and personal backgrounds, we maintain that trans students are engaged in a dialogue with hegemonic spatial discourses while reflecting critically on their spatial locations. The findings indicate that trans students experience periphery institutions as supportive, enabling them, through practices of collaborative activism and home-making, to create a politics from the ‘margins’ that displaces the ‘center’ as a site of inclusive queer activism. Accordingly, ‘peripheral’ locations enhance trans students’ social activism aimed at fostering change from the ‘margins’, radicalizing the ‘periphery’, and contributing to social change. On this basis, the present study demonstrates how peripheral spatial locations contribute to queer activism by undermining homonormativity while fostering ‘identification politics’ that promote solidarity and collaborative practices with various social sub-groups. This sheds light on the transformative aspects of peripheral locations and their contribution to social change, expanding current knowledge on the relationship among space, gender, and activism.
Land Use and Land Cover Change Strongly Modulates Land‐Atmosphere Coupling and Warm‐Season Precipitation Over the Central United States in CESM2‐VR

Prior research indicates that land use and land cover change (LULCC) in the central United States has led to significant changes in surface climate. The spatial resolution of simulations is particularly relevant in this region due to its influence on model skill in capturing mesoscale convective systems (MCSs) and on representing the spatial heterogeneity. Recent advances in Earth system models (ESMs) make it feasible to use variable resolution (VR) meshes to study regional impacts of LULCC while avoiding inconsistencies introduced by lateral boundary conditions typically seen in limited area models. Here, we present numerical experiments using the Community Earth System Model version 2–VR to evaluate (1) the influence of resolution and land use on model skill and (2) impacts of LULCC over the central United States at different resolutions. These simulations are configured either on the 1° grid or a VR grid with grid refinement to 1/8° over the contiguous United States for the period of 1984–2010 with two alternative land use data sets corresponding to the preindustrial and present day states. Our results show that skill in simulating precipitation over the central United States is primarily dependent on resolution, whereas skill in simulating 2‐m temperature is more dependent on accurate land use. The VR experiments show stronger LULCC‐induced precipitation increases over the Midwest in May and June, corresponding to an increase in the number of MCS‐like features and a more conductive thermodynamic environment for convection. Our study demonstrates the potential of using VR ESMs for hydroclimatic simulations in regions with significant LULCC.
Ultrafast electron dynamics in Mott materials

Mott insulators are a perfect example of how local electronic correlations can change macroscopic properties of materials. Varying slightly the doping or the pressure can transform a metal to an insulator. These properties can be modified extremely rapidly by driving these materials far from equilibrium. We have investigated the model Mott-Hubbard material Cr-doped V2O3 using state of the art pump-probe techniques, namely angle resolved photoelectron spectroscopy, optical reflectivity, THz time-domain spectroscopy, and X-ray diffraction. We were able to unequivocally disentangle the electronic and the lattice response of the system to a femtosecond laser excitation, which was kept in all cases at a wavelength of 800 nm. We present a comparative study of these transient responses, which demonstrates the strong electron-phonon coupling of this strongly correlated model material. We show that before thermalization, spectral weight is transferred from the lower Hubbard band towards the Mott gap. On a longer time scale a metastable state is stabilized by the lattice structure. To further understand the transient response of Mott insulators, we have also studied another Mott compound, BaCo1-xNixS2. The general trends of photoexcitation in Mott insulators are analyzed using a two orbital model. We argue that the filling of the gap can be due to a change of the specific orbital fillings.
Assessing Quantitative MRI Techniques using Multimodal Comparisons

The study of brain structure and change in neuroscience is commonly conducted using macroscopic morphological measures of the brain such as regional volume or cortical thickness, providing little insight into the microstructure and physiology of the brain. In contrast, quantitative MRI allows the monitoring of microscopic brain change non-invasively in-vivo, and provides normative values for comparisons between tissues, regions, and individuals. To support the development and common use of qMRI for cognitive neuroscience, we analysed a set of qMRI metrics (R1, R2*, Magnetization Transfer saturation, Proton Density saturation, Fractional Anisotropy, Mean Diffusivity) in 101 healthy young adults. Here we provide a comprehensive descriptive analysis of these metrics and their linear relationships to each other in grey and white matter to develop a more complete understanding of the relationship to tissue microstructure. Furthermore, we provide evidence that combinations of metrics may uncover informative gradients across the brain by showing that lower variance components of PCA may be used to identify cortical gradients otherwise hidden within individual metrics. We discuss these results within the context of microstructural and physiological neuroscience research.
Novel strand exchange activity of the human PALB2 DNA Binding Domain and its critical role for DNA repair in cells

Breast cancer associated proteins 1 and 2 (BRCA1, −2) and partner and localizer of BRCA2 (PALB2) protein are tumor suppressors linked to a spectrum of malignancies, including breast cancer and Fanconi anemia. They stimulate RAD51 recombinase during homology-directed repair (HDR). Along with being a hub for a protein interaction network, PALB2 interacts with DNA. The mechanism of PALB2 DNA binding and its function are poorly understood. We identified a major DNA-binding site in PALB2, mutation of which reduces the RAD51 foci formation and the overall HDR efficiency in cells by 50%. PALB2 N-terminal DNA-binding domain (N-DBD) stimulates the RAD51 strand exchange reaction. Surprisingly, it promotes the strand exchange without RAD51. Moreover, N-DBD stimulates the inverse strand exchange and can use both DNA and RNA substrates. Our data reveal a versatile DNA interaction property of PALB2 and demonstrate a critical role of PALB2 DNA binding for chromosome repair in cells.
APPLICATION OF CLUSTERING TECHNIQUES TO STUDY THE TRAINING PATTERN PROVIDED BY THE DIFFERENT INSTITUTES UNDER HSRT

1. Assistant Professor in Management, Department of Commerce and Management, West Bengal State University, Barasat, W.B. , India. 2. Faculty, University Institute of Technology, Burdwan, W.B. , India. 3. Faculty, Department of Business Administration, Burdwan Raj College, Burdwan, W.B. , India. Manuscript Info Abstract . Manuscript History Received: 10 April 2020 Final Accepted: 12 May 2020 Published: June 2020
LED driver based on novel ripple cancellation technique for flicker‐free operation and reduced power processing

Light-emitting-diode (LED) drivers are required to maintain the power quality of both the AC input and DC output side. The regulation prevents adverse impacts on the grid and maintains the nominal operating condition of LEDs. Without significant filtering, the input power from a single-phase AC source can result in low-frequency flickers that raise health issues. This study proposes a LED driver topology to achieve low harmonics at the AC side and maintain flicker-free operation to drive LEDs. A novel ripple-cancelling scheme is developed to minimise redundant power processing and reduce circuit complexity to achieve high-conversion efficiency. The new topology supports a simple control strategy to operate the driver effectively. Experimental evaluation demonstrates the system performance and verifies the novelty and contribution.