Miracle-dz/UniFAR-FTUs huggingface dataset:
Rancang Bangun Sistem Informasi Manajemen Pada PT. Samudera Abadi Teknologi Palembang Design and Development of Management Information System at

PT. Samudera Abadi Technology Palembang or known as PT. SATEC is a company engaged in the procurement of goods and services in Palembang city. The problems found in the business activities of PT. SATEC is the use of conventional methods such as the use of ledgers and computerization with simple word processing applications that need to be improved. After understanding the practical problems at PT. SATEC and supported by literature studies that have been done previously, this study designs and develops a management information system that is applied to PT. SATEC uses the RUP method through the stages of inception, elaboration, construction, and transition. This study uses a fishbone diagram to show the causal relationship of the problems that occur at PT. SATEC. This study resulted a management information system at PT. SATEC which can manage data related to buying and selling activities, procurement, inventory, and report management. The management information system that has been designed and built in this study is evaluated using the webuse method and gets a usability value of 0.79 which means the management information system at PT. SATEC has a good reputation.
Node Hypertrophy LIGHT Regulates Inflamed Draining Lymph

Lymph node (LN) hypertrophy, the increased cellularity of LNs, is the major indication of the initiation and expansion of the immune response against infection, vaccination, cancer, or autoimmunity. The mechanisms underlying LN hypertrophy remain poorly deﬁned. In this article, we demonstrate that LIGHT (homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by lymphocytes) (TNFSF14) is a novel factor essential for LN hypertrophy after CFA immunization. Mechanistically, LIGHT is required for the inﬂux of lymphocytes into but not egress out of LNs. In addition, LIGHT is required for dendritic cell migration from the skin to draining LNs. Compared with wild type mice, LIGHT 2 / 2 mice express lower levels of chemokines in skin and addressins in LN vascular endothelial cells after CFA immunization. We unexpectedly observed that LIGHT from radioresistant rather than radiosensitive cells, likely Langerhans cells, is required for LN hypertrophy. Importantly, Ag-speciﬁc T cell responses were impaired in draining LNs of LIGHT 2 / 2 mice, suggesting the importance of LIGHT regulation of LN hypertrophy in the generation of an adaptive immune response. Collec-tively, our data reveal a novel cellular and molecular mechanism for the regulation of LN hypertrophy and its potential impact on the generation of an optimal adaptive immune response. The Journal of Immunology , 2011, 186: 000–000.
ScienceDirect International Conference on Efficient & Sustainable Water Systems Management toward Worth Living Development , 2 nd EWaS 2016 A methodology to estimate leakages in water distribution networks based on inlet flow data analysis

Water loss control and reduction is a major issue in Water Distribution Network (WDN) management worldwide. In many WDNs, the infrastructure monitoring in terms of flow/pressure measurements through the network, is not implemented yet and only few data (e.g. measurement of WDN inflow) are available to estimate the current leakage rate. Cheap and easily applicable procedures are needed to estimate current water losses in WDNs aimed at understanding the actual magnitude of the phenomenon and planning interventions. This work presents a simple methodology, inspired by the analysis of WDN inflow data records collected in several real water distribution networks, which permits to assess leakages based on the seasonal fluctuation of water consumptions. The methodology is tested on two synthetic case studies based on the Apulian WDN, which hydraulic status is simulated by an advanced WDN model that includes a realistic pressure-dependent background leakage model. The analyses of case studies verifies the effectiveness of the methodology under fully controlled WDN configurations (e.g. neglecting measurement inaccuracies that might happen in real WDN and/or possible alterations of asset conditions over the analyzed period). The resulting estimates of leakages proved to be accurate under the analyzed condition, thus making the methodology promising for next applications on real WDNs. © 2016 The Authors. Published by Elsevier Ltd. Peer-review under responsibility of the organizing committee of the EWaS2 International Conference on Efficient & Sustainable Water Systems Management toward Worth Living Development. * Corresponding author. Tel. : +39-080-596-3672. E-mail address: orazio.giustolisi@poliba.it © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer-review under responsibility of the organizing committee of the EWaS2 International Conference on Efficient & Sustainable Water Systems Management toward Worth Living Development 412 Gianfredi Mazzolani et al. / Procedia Engineering 162 ( 2016 ) 411 – 418
Dynamic Characterization of KUKA Light-Weight Robot Manipulators

High precision tasks are an important part of the manufacturing industry. For example, safety constraints require that some manufacturing must be done to a very high degree of accuracy. Robotics and automation are well suited for such tasks, as there is high repeatability on specialized repetitive tasks. Robotics has a long history in manufacturing in the form of industrial automation. Yet these robotic systems tend to be very large, restricting their use to tasks in open spaces that are easily accessible to the robot. In the last few years there have been a number of advances in the area of small, light weight robots. One such robot is the KUKA Light-Weight Robot (LBR) [1]. With the availability of smaller robot manipulators, the question arises of whether it would be feasible to use them in tasks that would otherwise be unsuitable for the standard large industrial robots. Possible tasks would be those in tight or constrained spaces, such as in sub-structure drilling. For this to be possible, the light weight robot would need to be stiff enough to be able to meet safety constraints. To that end, this study is to determine whether the dynamic characteristics, specifically stiffness, of small light weight robots would make it possible for them to be used in manufacturing. Two light weight robots are considered in this study, the LBR and the KUKA KR5 sixx.
High Speed S-band Communications System for Nanosatellites

3Cat-3 is a nanosatellite based on the 6 unit cubesat standard. Its payload is an optical multispectral imager that imposes stringent downlink requirements for a nanosatellite. This TFG is based on the experience gained in 3Cat-1 and 3Cat-2 communications systems to develop a "high speed" (goal >= 5 Mbps) downlink for nanosatellites based on the TI CC3200.
Antigen-Conjugated Human IgE Induces Antigen-Specific T Cell Tolerance in a Humanized Mouse Model

Dendritic cells (DCs) play an important role in immune homeostasis through their ability to present Ags at steady state and mediate T cell tolerance. This characteristic renders DCs an attractive therapeutic target for the induction of tolerance against auto-antigens or allergens. Accordingly, Ag-conjugated DC–specific Abs have been proposed to be an excellent vehicle to deliver Ags to DCs for presentation and tolerance induction. However, this approach requires laborious reagent generation procedures and entails unpredictable side effects resulting from Ab-induced crosslinking of DC surface molecules. In this study, we examined whether IgE, a high-affinity, non–cross-linking natural ligand of FcεRI, could be used to target Ags to DCs and to induce Ag-specific T cell tolerance. We found that Ag-conjugated human IgE Fc domain (Fcε) effectively delivered Ags to DCs and enhanced Ag presentation by 1000- to 2500-fold in human FcεRIα-transgenic mice. Importantly, this presentation resulted in a systemic deletion of Ag-specific T cells and prevented these mice from developing delayed-type hypersensitivity, which is critically dependent on Ag-specific T cell immunity. Thus, targeting FcεRI on DCs via Ag-Fcε fusion protein may serve an alternative method to induce Ag-specific T cell tolerance in humans.
Counterfactual harm

To act safely and ethically in the real world, agents must be able to reason about harm and avoid harmful actions. However, to date there is no statistical method for measuring harm and factoring it into algorithmic decisions. In this paper we propose the first formal definition of harm and benefit using causal models. We show that any factual definition of harm must violate basic intuitions in certain scenarios, and show that standard machine learning algorithms that cannot perform counterfactual reasoning are guaranteed to pursue harmful policies following distributional shifts. We use our definition of harm to devise a framework for harm-averse decision making using counterfactual objective functions. We demonstrate this framework on the problem of identifying optimal drug doses using a dose-response model learned from randomized control trial data. We find that the standard method of selecting doses using treatment effects results in unnecessarily harmful doses, while our counterfactual approach allows us to identify doses that are significantly less harmful without sacrificing efficacy.
Invariance Through Latent Alignment

A robot's deployment environment often involves perceptual changes that differ from what it has experienced during training. Standard practices such as data augmentation attempt to bridge this gap by augmenting source images in an effort to extend the support of the training distribution to better cover what the agent might experience at test time. In many cases, however, it is impossible to know test-time distribution-shift a priori, making these schemes infeasible. In this paper, we introduce a general approach, called Invariance Through Latent Alignment (ILA), that improves the test-time performance of a visuomotor control policy in deployment environments with unknown perceptual variations. ILA performs unsupervised adaptation at deployment-time by matching the distribution of latent features on the target domain to the agent's prior experience, without relying on paired data. Although simple, we show that this idea leads to surprising improvements on a variety of challenging adaptation scenarios, including changes in lighting conditions, the content in the scene, and camera poses. We present results on calibrated control benchmarks in simulation -- the distractor control suite -- and a physical robot under a sim-to-real setup.
Characterization and consumer acceptance of white striping in broiler breast fillets

White striping is an emerging issue in the broiler meat industry which causes concerns among the producers. The condition is characterized by the occurrence of white striations, parallel to the direction of muscle fibers, mainly in broiler breast fillets and thighs. Fillets can be categorized as NORM (normal or no striping), MOD (moderate) and SEV (severe) depending on the degree of white striping. As a result of few previous research studies on the condition, there is no information available on the impact of white striping on the consumer acceptance and various meat quality attributes. Our hypothesis was that the occurrence of the condition could be associated with tissue changes in meat and the physical appearance of the striations on the meat may affect the purchase intent of the product. The present study was intended to determine the consumer acceptance, meat quality and pathological changes associated with different degrees of white striping. The effects of growth rate, strain, gender, and dietary vitamin E level on the occurrence of condition were also evaluated. The results from the present study showed that MOD and SEV degrees of white striping reduced (P < 0.05) the consumer acceptance of the broiler breast fillets due to its marbled or fatty appearance. However, the condition did not show (P > 0.05) any effect on cooked meat quality attributes, mainly tenderness. Serologic profile and the histopathological findings indicated chronic myopathic tissue changes associated with higher degrees of white striping. These tissue changes were also manifested as increase in fat (P < 0.05) and decrease (P < 0.05) in protein contents as the degree of white striping increased from NORM to SEV. The occurrence of MOD and SEV degrees was closely associated (P < 0.05) with heavier birds or increased growth rate in broilers. Nonetheless, the incidence of the condition showed neither any strain/gender predilection nor relation to dietary vitamin E level. In conclusion, white striping is a growth associated myopathic condition seen in fast growing broiler birds which can affect the consumer acceptance and proximate composition of broiler
3-D laser vibrometry on legendary old Italian violins

Although the violin, one of the oldest mature mechanical dynamic systems, has been the subject of scientific investigation for two centuries, a scientific "silver bullet" for quality is still elusive. The fact that two shells (top and back plates, but especially the top] are considered of prime importance for quality implies that in-plane (IP) as well as out-of-plane (OP) vibrational behaviors are important. In-plane mobilities, uniquely available from three-dimensional, scanning-laser Doppler vibrometry, were obtained for three exemplary violins from the legendary Cremonese makers Antonio Stradivari and Giuseppi Guarneri del Gesu. Combining the vibration results with acoustic scans of their far-field radiation (and CT scans for material shape and density for future solid modeling) provided a wealth of information on the vibration-radiation conversion. One Stradivari, with the highest OP/IP mobility ratio for the top, also had the highest directivity for its sound (and the highest of 17 violins examined to date).
Posturographic study of human body sway before and after a work day for diagnosis of tiredness

Body sway measured by force platform is an excellent simple test for diagnostics of locomotory, balance, visual and neural disorders. In this study the body sway parameters have been measured on a group of healthy medical workers in the morning/evening time before/after their work day. The centre of pressure (CoP) trajectories in a series of different 2-leg stances and during a step forward off from the force platform have been recorded. It was found, in the morning the sway amplitudes were higher due to relaxed state of muscles, while after the work day the muscles were tired and the force platform test demanded more attention and body control which mostly lead to lower body sway amplitudes. The step off from the platform were executed faster in the evening, and the more elderly individuals exhibited more pronounced pathological signs in the CoP trajectory in the evening. Basing on the data analysis, new indices of tiredness and stress level are proposed for occupational medicine. Keywords: body sway, posture balance, control, medical diagnostics, stress, tiredness
Maintaining physical activity post-event? Case of the Tour of Flanders Cyclo in Belgium

Social ecological theory describes how physical activity participation is influenced by various systems and targets. This study conceptualizes the organization of a participatory sport event as one such target and seeks to understand what other elements of the individual and community systems are important for event participants to be physically active. The case of the Tour of Flanders Cyclo, Belgium's most popular participatory cycling event, is examined. Data were collected from participants through an online survey both before (N = 1091) and after the event (N = 639). Although the individual profile of event participants was homogeneous, significant differences – especially in terms of physical activity participation – were found between the different event distances of 83, 133 and 259 km. Individual behaviour and community resources were important to facilitate engagement with physical activity, which has implications for organizing participatory sport events in conjunction with other community targets.
Immunoregulation in Diabetic Wound Repair with a Photoenhanced Glycyrrhizic Acid Hydrogel Scaffold

M1 macrophage accumulation and excessive inflammation are commonly encountered issues in diabetic wounds and can fail in the healing process. Hence, hydrogel dressings with immunoregulatory capacity have great promise in the clinical practice of diabetic wound healing. However, current immunoregulatory hydrogels are always needed for complex interventions and high‐cost treatments, such as cytokines and cell therapies. In this study, a novel glycyrrhizic acid (GA)‐based hybrid hydrogel dressing with intrinsic immunoregulatory properties is developed to promote rapid diabetic wound healing. This hybrid hydrogel consists of interpenetrating polymer networks composed of inorganic Zn2+‐induced self‐assembled GA and photo‐crosslinked methyl acrylated silk fibroin (SF), realizing both excellent injectability and mechanical strength. Notably, the SF/GA/Zn hybrid hydrogel can regulate macrophage responses in the inflammatory microenvironment, circumventing the use of any additives. The immunomodulatory properties of the hydrogel can be harnessed for safe and efficient therapeutics that accelerate the three phases of wound repair and serve as a promising dressing for the management of diabetic wounds.
Case fatality risk of diarrhoeal pathogens: a systematic review and meta-analysis

Abstract Background Estimates of the relative contribution of different pathogens to all-cause diarrhoea mortality are needed to inform global diarrhoea burden models and prioritize interventions. We aimed to investigate and estimate heterogeneity in the case fatality risk (CFR) of different diarrhoeal pathogens. Methods We conducted a systematic review and meta-analysis of studies that reported cases and deaths for 15 enteric pathogens published between 1990 and 2019. The primary outcome was the pathogen-specific CFR stratified by age group, country-specific under-5 mortality rate, setting, study year and rotavirus vaccine introduction status. We developed fixed-effects and multilevel mixed-effects logistic regression models to estimate the pooled CFR overall and for each pathogen, controlling for potential predictors of heterogeneity. Results A total of 416 studies met review criteria and were included in the analysis. The overall crude CFR for all pathogens was 0.65%, but there was considerable heterogeneity between and within studies. The overall CFR estimated from a random-effects model was 0.04% (95% CI: 0.026%–0.062%), whereas the pathogen-specific CFR estimates ranged from 0% to 2.7%. When pathogens were included as predictors of the CFR in the overall model, the highest and lowest odds ratios were found for enteropathogenic Escherichia coli (EPEC) [odds ratio (OR) = 3.0, 95% CI: 1.28–7.07] and rotavirus (OR = 0.23, 95% CI: 0.13–0.39), respectively. Conclusion We provide comprehensive estimates of the CFR across different diarrhoeal pathogens and highlight pathogens for which more studies are needed. The results motivate the need for diarrhoeal interventions and could help prioritize pathogens for vaccine development.
Cancer driver drug interaction explorer

Abstract Cancer is a heterogeneous disease characterized by unregulated cell growth and promoted by mutations in cancer driver genes some of which encode suitable drug targets. Since the distinct set of cancer driver genes can vary between and within cancer types, evidence-based selection of drugs is crucial for targeted therapy following the precision medicine paradigm. However, many putative cancer driver genes can not be targeted directly, suggesting an indirect approach that considers alternative functionally related targets in the gene interaction network. Once potential drug targets have been identified, it is essential to consider all available drugs. Since tools that offer support for systematic discovery of drug repurposing candidates in oncology are lacking, we developed CADDIE, a web application integrating six human gene-gene and four drug-gene interaction databases, information regarding cancer driver genes, cancer-type specific mutation frequencies, gene expression information, genetically related diseases, and anticancer drugs. CADDIE offers access to various network algorithms for identifying drug targets and drug repurposing candidates. It guides users from the selection of seed genes to the identification of therapeutic targets or drug candidates, making network medicine algorithms accessible for clinical research. CADDIE is available at https://exbio.wzw. tum.de/caddie/ and programmatically via a python package at https://pypi.org/project/caddiepy/.
Promyelocytic leukemia nuclear body-like structures can assemble in mouse oocytes

ABSTRACT Promyelocytic leukemia (PML) nuclear bodies (PML-NBs), a class of membrane-less cellular organelles, participate in various biological activities. PML-NBs are known as the core-shell-type nuclear body, harboring ‘client’ proteins in their core. Although multiple membrane-less organelles work in the oocyte nucleus, PML-NBs have been predicted to be absent from oocytes. Here, we show that some well-known PML clients (but not endogenous PML) co-localized with small ubiquitin-related modifier (SUMO) protein in the nucleolus and peri-centromeric heterochromatin of maturing oocytes. In oocytes devoid of PML-NBs, endogenous PML protein localized in the vicinity of chromatin. During and after meiotic resumption, PML co-localized with SUMO gathering around chromosomes. To examine the benefit of the PML-NB-free intranuclear milieu in oocytes, we deliberately assembled PML-NBs by microinjecting human PML-encoding plasmids into oocytes. Under conditions of limited SUMO availability, assembled PML-NBs tended to cluster. Upon proteotoxic stress, SUMO delocalized from peri-centromeric heterochromatin and co-localized with SC35 (a marker of nuclear speckles)-positive large compartments, which was disturbed by pre-assembled PML-NBs. These observations suggest that the PML-NB-free intranuclear environment helps reserve SUMO for emergent responses by redirecting the flux of SUMO otherwise needed to maintain PML-NB dynamics.