Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of incidence of motor neuron disease in England 1998–2019: use of three linked datasets

Abstract Objective: This study uses three linked datasets to provide an estimate of incidence of motor neuron disease (MND) in England from 1998 to 2019. Comparison is made to previous British studies. It examines age at diagnosis and ethnicity of those affected. Methods: The literature was searched for studies of MND incidence in Great Britain from 1995 to date. The QResearch and linked Hospital Episode Statistics and Death register databases were searched from 1998 to 2019 for cases of MND, and incidence calculated from 16.8 million adults and 112 million adult years of data. Results: We found 6437 adults with a diagnosis of MND giving an incidence of MND of 5.69/100,000 person years (95% CI 5.51–5.88); 6.57 (6.41–6.99) in men and 4.72 (4.49–4.97) in women when age-standardized to the 2011 UK population. The median age of diagnosis was 72 years. Peak incidence occurred in the 80–84 year age group in men and 75–79 in women. Age-standardized incidence was as high in Bangladeshi, Black Caribbean, Indian, other Asian and Pakistani people as in White people. Black African and Chinese people had a lower incidence. Conclusion: The use of three linked national datasets captured 33% more people than a primary care dataset alone. Patients were older than in previous studies and rates were high in all ethnic groups studied except Black African and Chinese people. We present the highest incidence of MND reported globally in the past 50 years. Methodological differences may in part explain differences with previous reports. The use of national datasets may have captured additional MND patients with serious comorbidities who have not seen a neurologist before death. A limitation of this approach is that unlike population registers, which minimize false positive diagnosis by neurologist review of each patient, we cannot review diagnosis for individuals as data are anonymized.
The Design of Low‐Cost Stand‐Alone Microcontroller‐Based Wireless Ultrasonic System for Process Monitoring and Analysis

Ultrasound technology is currently used in many areas, such as imaging, analysis, and process monitoring. The noninvasive implementation, nondestructive effect on the material to be applied, and low cost of the needed components give an advantage to the ultrasonic systems when compared to other methods for analysis and process monitoring studies. However, the current ultrasonic analysis setups used in the studies require additional devices such as a signal generator and oscilloscope. These devices used in the setup increase the cost, size, usage difficulty of the system and, most importantly, decrease the portability and stability. In order to prevent these disadvantages, an ultrasonic system that can work in real‐time and its software are developed to be used in analysis and process monitoring without any additional devices.
D3 Versus D2 Lymphadenectomy in Right Hemicolectomy: A Systematic Review and Meta-analysis

Purpose D3 lymphadenectomy for right colon cancer improves oncological outcomes. This meta-analysis aimed to compare operation data, histopathological characteristics, perioperative conditions, and long-term survival after D3 and D2 lymphadenectomy in right hemicolectomy. Methods We searched PubMed, Embase, and the Cochrane Library for relevant articles (up to March 31, 2020). Random-effects and fixed-effects meta-analysis models were used. Review Manager (RevMan) version 5.3 and Stata version 15.1 were used for pooled estimates. Results After screening 714 articles, 7 articles with a total of 1368 patients were eligible for inclusion. Compared with D2, D3 lymphadenectomy improves results in terms of blood loss (weighted mean difference [WMD] = −20.63, 95% confidence interval [CI] −28.19 to −13.16, P < .01), harvested lymph nodes (WMD = 8.86, 95% CI 7.74 to 9.98, P < .01), 3-year overall survival (OS) (hazard ratio [HR] = 2.03, 95% CI 1.20 to 3.43, P < .01), 5-year OS (HR = 2.22, 95% CI 1.15 to 4.30, P = .02), and 5-year disease-free survival (DFS) (HR = 2.16, 95% CI 1.19 to 3.90, P = .01). There was no significant difference regarding operation time, anastomosis leakage, wound infection, overall morbidity, postoperative hospital stay, mortality, length of dissected colon, and 3-year DFS (P >= .05). Conclusions It is suggested in this review that D3 lymphadenectomy is superior to D2 lymphadenectomy in terms of blood loss, harvested lymph nodes, 3-year OS, 5-year OS, and 5-year DFS. The conclusion must be drawn with caution due to the limited number of included studies. Further RCTs are needed for stronger evidence.
Behavioural Activation for Social IsoLation (BASIL+) trial (Behavioural activation to mitigate depression and loneliness among older people with long-term conditions): Protocol for a fully-powered pragmatic randomised controlled trial

Abstract Introduction Depression is a leading mental health problem worldwide. People with long-term conditions are at increased risk of experiencing depression. The COVID-19 pandemic led to strict social restrictions being imposed across the UK population. Social isolation can have negative consequences on the physical and mental wellbeing of older adults. In the Behavioural Activation in Social IsoLation (BASIL + ) trial we will test whether a brief psychological intervention (based on Behavioural Activation), delivered remotely, can mitigate depression and loneliness in older adults with long-term conditions during isolation. Methods We will conduct a two-arm, parallel-group, randomised controlled trial across several research sites, to evaluate the clinical and cost-effectiveness of the BASIL + intervention. Participants will be recruited via participating general practices across England and Wales. Participants must be aged [≥]65 with two or more long-term conditions, or a condition that may indicate they are within a clinically extremely vulnerable group in relation to COVID-19, and have scored [≥]5 on the Patient Health Questionnaire (PHQ9), to be eligible for inclusion. Randomisation will be 1:1, stratified by research site. Intervention participants will receive up to eight intervention sessions delivered remotely by trained BASIL + Support Workers and supported by a self-help booklet. Control participants will receive usual care, with additional signposting to reputable sources of self-help and information, including advice on keeping mentally and physically well. A qualitative process evaluation will also be undertaken to explore the acceptability of the BASIL + intervention, as well as barriers and enablers to integrating the intervention into participants existing health and care support, and the impact of the intervention on participants mood and general wellbeing in the context of the COVID-19 restrictions. Semi-structured interviews will be conducted with intervention participants, participants caregivers/supportive others and BASIL + Support Workers. Outcome data will be collected at one, three, and 12 months post-randomisation. Clinical and cost-effectiveness will be evaluated. The primary outcome is depressive symptoms at the three-month follow up, measured by the PHQ9. Secondary outcomes include loneliness, social isolation, anxiety, quality of life, and a bespoke health services use questionnaire. Discussion This study is the first large-scale trial evaluating a brief Behavioural Activation intervention in this population, and builds upon the results of a successful external pilot trial. Trial Registration ClinicalTrials.Gov identifier ISRCTN63034289, registered on 5th February 2021.
Plants in the UK flower a month earlier under recent warming

Global temperatures are rising at an unprecedented rate, but environmental responses are often difficult to recognize and quantify. Long-term observations of plant phenology, the annually recurring sequence of plant developmental stages, can provide sensitive measures of climate change and important information for ecosystem services. Here, we present 419 354 recordings of the first flowering date from 406 plant species in the UK between 1753 and 2019 CE. Community-wide first flowering advanced by almost one month on average when comparing all observations before and after 1986 (p < 0.0001). The mean first flowering time is 6 days earlier in southern than northern sites, 5 days earlier under urban than rural settings, and 1 day earlier at lower than higher elevations. Compared to trees and shrubs, the largest lifeform-specific phenological shift of 32 days is found in herbs, which are generally characterized by fast turnover rates and potentially high levels of genetic adaptation. Correlated with January–April maximum temperatures at −0.81 from 1952–2019 (p < 0.0001), the observed trends (5.4 days per decade) and extremes (66 days between the earliest and latest annual mean) in the UK's first flowering dataset can affect the functioning and productivity of ecosystems and agriculture.
Allee effects and the Allee-effect zone in northwest Atlantic cod

According to the theory of compensatory dynamics, depleted populations should recover when the threat responsible for their decline is removed because per capita population growth is assumed to be highest when populations are at their smallest viable sizes. Yet, many seriously depleted fish populations have failed to recover despite threat mitigation. Atlantic cod (Gadus morhua) stocks off Newfoundland, despite 30 years of dramatically reduced fishing mortality and numerous fishery closures, have not recovered, suggesting that drivers other than fishing can regulate the growth of collapsed fish populations, inhibiting or preventing their recovery. Here, using Bayesian inference, we show strong evidence of Allee effects in a south Newfoundland cod population, based on data on recruitment and spawning stock biomass. We infer the Allee-effect threshold, below which recovery is impaired. We demonstrate the necessity of data at low population sizes to make inferences about the nature of low-abundance dynamics. Our work indicates that Allee effects are not negligible in commercially exploited fish populations, as commonly projected, and that they represent an inhibitory force that can effectively prevent recovery from overfishing. Our findings contrast with prevailing fisheries management practices that assume compensatory dynamics at low abundances with potential to seriously overestimate the recovery potential of collapsed populations.
A non-parametric model: free analysis of actigraphic recordings of acute insomnia patients

Both parametric and non-parametric approaches to time-series analysis have advantages and drawbacks. Parametric methods, although powerful and widely used, can yield inconsistent results due to the oversimplification of the observed phenomena. They require the setting of arbitrary constants for their creation and refinement, and, although these constants relate to assumptions about the observed systems, it can lead to erroneous results when treating a very complex problem with a sizable list of unknowns. Their non-parametric counterparts, instead, are more widely applicable but present a higher detrimental sensitivity to noise and low density in the data. For the case of approximately periodic phenomena, such as human actigraphic time series, parametric methods are widely used and concepts such as acrophase are key in chronobiology, especially when studying healthy and diseased human populations. In this work, we present a non-parametric method of analysis of actigraphic time series from insomniac patients and healthy age-matched controls. The method is fully data-driven, reproduces previous results in the context of activity offset delay and, crucially, extends the concept of acrophase not only to circadian but also for ultradian spectral components.
Good Tech and Social Good: Value Creation by Korean Social and High-Tech Oriented Start-Ups

Through an exploration of Korean high-tech social enterprises, we aim to identify and explore critically (a) how socially engaged, early stage, high technology firms combine social and economic objectives with which to scale up their ventures; and (b) how socially engaged firms seek entrepreneurial opportunity development, including the internationalisation process and the support of stake holding institutions to help scale up the value creation process. We highlight ‘people’, ‘organisations’ and the ‘environment’ dimensions, enabling an understanding of the drivers of socially entrepreneurial activity both from individual and societal perspectives. The analytical framework of our study is based on empirical data acquired from individual in-depth interviews, group interviews, active participatory observations and survey data from 2018 to 2021. We found that social motivation and objectives of the entrepreneurs are equally strong drivers and that they are the principal factors for the scaling up process. The motivation is strengthened by the proactive role of government initiatives which also attract other key stakeholders in the growth process. A combination of digital technology with a high degree of social motivation of the entrepreneurs tends to lead to the development of international market opportunities and attract the interests of international foundations.
Genetic diversity and population structure for ocelots (Leopardus pardalis) in Costa Rica

Ocelots (Leopardus pardalis) are a wide-ranging felid species, occurring from southern United States to northern Argentina. They occupy various habitats and are usually considered the most abundant wild cat species in the Neotropics. However, genetic studies that include free-ranging Mesoamerican ocelots are rare and generally based on small sample sizes. This is the first conservation genetics study on ocelots in Costa Rica and the second one in Mesoamerica that has conducted a genetic assessment of the species at a countrywide scale. We evaluated genetic diversity and population structure of ocelots using 15 microsatellite loci in 28 successfully genotyped individuals from throughout the country. We also compared genetic diversity of Costa Rican ocelots with that of jaguars (Panthera onca) and pumas (Puma concolor) in the country, and with ocelots in Belize. Genetic diversity of ocelots in Costa Rica was relatively high as measured by rarified allelic richness (AR = 5.50 ± 1.36) and expected heterozygosities (HE = 0.79 ± 0.08). We did not detect patterns of genetic substructure, suggesting high levels of gene flow throughout the country and no strong barriers to movement. As expected, genetic diversity of Costa Rican ocelots was higher than co-occurring jaguars and pumas. Additionally, levels of genetic diversity were slightly higher in Costa Rican ocelots when compared with their counterparts in Belize, confirming the south to north decrease in genetic diversity reported in other studies. Our study provides critical baseline information to understand the status of wild ocelot populations in Costa Rica. Future studies on ocelots and other threatened or keystone species should also integrate genetic monitoring and conservation genetics analysis to properly inform management decisions, guarantee their long-term survival, and improve the resilience of ecosystems.
A genomic portrait of Sturnira parvidens: mitochondrial chromosome, repetitive elements, and microsatellite discovery

The yellow-shouldered bat, Sturnira parvidens (Phyllostomidae), is an abundant and widespread species in southern North America and Mesoamerica. Despite its important ecological role, no genomic resources exist for this species. Using low-coverage short Illumina 150 bp pair-end reads sequencing, this study reports the mitochondrial chromosome and nuclear repetitive elements, including microsatellites, in S. parvidens. The mitochondrial genome of S. parvidens is 16,612 bp in length and is comprised of 13 protein-coding genes, 2 ribosomal RNA genes, and 22 transfer RNA genes. Repetitive elements constituted ∼67% of the nuclear genome while ∼33% of the genome represented single- or low-copy sequences. A moderate proportion of repetitive sequences (31% putative families) could not be assigned to known repeat element families. Considering only annotated repetitive elements, the most ubiquitous repetitive elements belonged to Class I-LINE and Satellite DNA, which were considerably more abundant than Class I-LTR elements and Class II-DNA transposons (TcMar-Mariner and hAT-Charlie). A total of 193 microsatellites were identified.
Effects of capture on stress-axis measures in endangered little brown bats (Myotis lucifugus)

Little brown bats (Myotis lucifugus) are a widely distributed species in North America that have been decimated by the fungal disease white-nose syndrome. As such, little brown bats are the focus of monitoring and research initiatives that often include capturing and handling free-ranging individuals. We examined the stress response of 198 adult female little brown bats after being captured from three bat houses, during the summer. Our objective was to inform best practices to researchers capturing and handling bats in the wild. We compared the stress response among bats held for <3 min (baseline), 15–30 min, or >30 min, and then among bats held alone or in a group with conspecifics. We measured the levels of plasma total and free cortisol, maximum corticosteroid binding capacity (MCBC), and blood glucose. Relative to baseline, total and free cortisol levels were significantly higher in bats held for 15–30 min and higher still in those held for > 30 min. Blood glucose levels were elevated after >30 min of holding. MCBC levels showed no differences among holding times. We detected a weak effect of social holding condition, with solitary-held bats having lower total cortisol levels than group-held bats, but MCBC, free cortisol, and blood glucose levels showed no effect of social holding condition. Our findings demonstrate that capture time should be minimized and suggest that little brown bats should be handled and released within 30 min of capture as means of reducing stress. Further, solitary holding did not appear to increase stress measures, which supports holding bats individually after capture, instead of in groups, to reduce risk of pathogen and parasite transmission.
The decline in public investment: ``social dominance’’ or too-rigid fiscal rules?

ABSTRACT Public investment in advanced economies is at historical lows, following a declining trend since the 1980s. Two main hypotheses have been posed to explain this evolution: (i) the ‘social dominance hypothesis’, whereby increased public social spending has been displacing investment from government’s budgets, despite the upward trend witnessed in tax burdens and debt; (ii) fiscal rules’ frameworks, that would have forced governments to reduce investment in their quest for compliance. In this paper, we jointly test the validity of these two duelling explanations using two empirical approaches (panel data models; local projections) for a sample of advanced economies comprising data for the past six decades. We find that both factors are relevant to explain the observed downward trend in investment, with social spending acting as a structural driver, whereas fiscal rules contributed mainly when applied in fiscal consolidation episodes.
Impacts of Different Habitats on the Composition of Bacterial Communities at the Discharging Endpoints of a Hypogene Thermal Karst System

Abstract The discharging zones of thermal karst caves provide special environmental conditions for bacteria involved in the biogeochemical processes. The taxonomic composition of bacterial communities inhabiting these still active natural habitats is largely unknown. The aim of this study was to reveal and compare the bacterial diversity of upwelling thermal waters, rock surface biofilms, and cave deposits using high-throughput next-generation sequencing. Two thermal karst caves formed in carbonate rocks and located at the discharging endpoints of the Transdanubian Range (Hungary) were studied: a sublacustrine spring cave and a phreatic hypogene cave. The results of 16S rRNA gene-based Illumina MiSeq amplicon sequencing revealed that almost all samples were dominated by Proteobacteria and/or Epsilonbacteraeota. Other abundant phyla showed habitat-dependent and diverse distributions. Sequences of the thermal waters were mainly associated with different chemolithotrophic sulfur-oxidizing bacteria (genera Thiovirga, Thiofaba, and Arcobacter in the sublacustrine thermal spring cave, whereas genera Sulfurovum, Sulfuricurvum, and Sulfurifustis were characteristic of the phreatic hypogene thermal cave) in accordance with the difference in environmental parameters. Sequences belonging to ammonia-oxidizing (unclassified Nitrosococcaceae) and nitrite-oxidizing bacteria (Nitrospira) were characteristic of the hypogene cave. Sequences related to photoautotrophic bacteria from the lake water and chemoheterotrophic bacteria from the sediment were only found in the sublacustrine spring cave samples.
IABSE Congress Ghent 2021 “Structural Engineering for Future Societal Needs”

From 22 to 24 September 2021, 287 structural engineers participated in the IABSE Congress Ghent 2021 with the overall theme “Structural engineering for future societal needs”. This Congress, jointly organised by the Belgian and the Dutch National Groups of IABSE, was originally planned to take place on site in Ghent, then due to the Covid-19 pandemic it was changed into a hybrid Congress to eventually become a fully online Congress in the end. Four important topics, namely: reliability, circularity, CO2 footprint and climate change were addressed. These also formed important subthemes of the Congress with Keynote Speakers related to these topics.
Posttraumatic Growth and Migrations: A Transcultural Study in France and Brazil

Abstract The goals of this study were to compare the levels of post-traumatic growth (PTG) in migrants living in France and in Brazil and to investigate the factors associated with it. Two hundred and three participants took part in the study, with 103 living in Brazil and 100 living in France. In France, low levels of PTG were reported while in Brazil moderate levels were identified. In both countries, lack of food was negatively related to PTG and worries about family in the home country was a positive predictor. In France, PTG was positively predicted by regular migratory status while post-traumatic stress disorder negatively predicted it.
Uniportal video‐assisted thoracic surgery approach for simultaneous lung cancer and thymic carcinoma: Case report and literature review

Thymic carcinoma is an epithelial tumor derived from thymic epithelial cells. Thymic tumors may be associated with other simultaneous and/or metachronous extra‐thymic tumors (e.g., lung cancer). Here, we report a case of simultaneous surgical management of lung and mediastinal neoplasm together with a review of the literature. During radiological follow‐up for prostate and colorectal cancer, an 82‐year‐old man was diagnosed with lung cancer with simultaneous mediastinal suspected neoplasm. Both were surgically removed with a single intervention performed via a uniportal video‐assisted thoracic surgery (uni‐VATS) approach. The literature emphasizes how extra‐thymic cancer can be diagnosed before, concurrently and consecutively with thymic neoplasia. The surgical treatment of such simultaneous cancer is challenging. We succeeded in the excision of both neoplasia with a mini‐invasive surgical technique. This report highlights the feasibility of uniportal VATS in a patient with very unusual clinical and oncological history.