Miracle-dz/UniFAR-FTUs huggingface dataset:
Bleeding complications after percutaneous coronary interventions in patients treated with abciximab in relation to dose of clopidogrel Powik³ania krwotoczne po przezskórnych interwencjach wieñcowych u pacjentów leczonych abciksimabem w zale¿noœci od zastosowanej oko³ozabiegowo dawki klopidogrelu

Background: Administration of potent and fast-acting medications inhibiting platelet adhesion and aggregation is crucial to improve outcomes of percutaneus interventions. Aim: To compare the incidence of bleeding complications in patients treated with abciximab and different doses of clopidogrel. Additonal aim of the study was to compare the decrease of hemoglobin concentration. Methods: Medical records of patients who underwent invasive procedure between 2003 and 2006 were retrospectively analyzed. Patients treated with abciximab in standard dose and 75 mg or 300 mg of clopidogrel as the concomitant therapy were included. Exclusion criteria included: myocardial infarction caused by in-stent thrombosis, previous treatment with thienopyridine, participation in clinical trial with medication influencing the coagulation cascade, application of IIb/IIIa receptor inhibitor other than abciximab, lack of data in electronic records. For the purpose of the analysis of changes in the haemoglobin concentration patients who underwent surgical procedure were exluded. Results: Study group consisted of 324 patients, of whom 165 received 75 mg of clopidogrel and 159 received 300 mg of clopidogrel. Following complications were registered: haematoma of the arterial access site (diagnosis based on ultrasonography – organized hematoma exceeding 3 cm in diameter), pseudoaneurysm, retroperitoneal haematoma, gastrointestinal bleeding, haematuria. These complications was present in 6.7% patients who received 75 mg of clopidogrel and 11.9% patients who received 300 mg of clopidogrel (p = 0.1). Haemoglobin concentration decreased by 1.35 (0.6-2.2) g/dl in 75 mg group and by 1.8 (0.9-2.6) g/dl in 300 mg group (p = 0.046), respectively. Conclusions: Administration of 300 mg of clopidogrel together with abciximab is not significantly related to a higher frequency of bleeding complications, but it is related to a higher decrease of haemoglobin concentration in comparison to administration of 75 mg of clopidogrel. Special awareness concerning bleeding complications is needed when applying aggressive antiplatelet therapy.
[3-(2-Hydroxy­phenyl)-5-phenyl-4,5-dihydropyrazol-1-yl](pyridin-3-yl)methanone

In the title compound, C21H17N3O2, the dihedral angles between the central pyrazole and the substituent pyridine, hydroxy­phenyl and benzene rings are 48.58 (1), 5.2 (1) and 84.73 (1)°, respectively.
User interface design for the Hyperties electronic encyclopedia

Printed books were an enormous stimulus to science, culture, commerce, and entertainment. Electronic books and hypertext systems may produce a similar stimulus in the next century, but current designs are poor. Typical screens are too small, too slow, too complicated, and too hard to read. With careful attention to the user interface and the underlying technology, we have a chance to create a new medium that is potentially more attractive and effective than printed books in many situations.
(Biphenyl-4-yl)(phenyl)methanone

In the title compound, C19H14O, the dihedral angle between the two aromatic rings of the biphenyl residue is 8.0 (3)° and the dihedral angle between the two rings connected by the carbonyl C atom is 51.74 (18)°. There are no short C—H⋯O contacts in the crystal structure.
Tetrakis(μ-3,4-dimethoxyphenylacetato)bis[(3,4-dimethoxyphenylacetato)(1,10-phenanthroline)holmium(III)]

In the centrosymmetric title compound, [Ho(2)(C(10)H(11)O(4))(6)(C(12)H(8)N(2))(2)], the Ho(III) atom is nine-coordinated by seven O atoms from the 3,4-dimeth-oxy-phenyl-acetate (L) anions and two N atoms from a 1,10-phenanthroline (phen) mol-ecule. The L ligands are coordinated to the Ho(III) ions in three modes: chelating, bridging and bridging-tridentate. Intra-molecular C-H⋯O inter-actions occur. The crystal packing is stabilized by inter-molecular C-H⋯O inter-actions and weak aromatic π-π inter-actions between phen mol-ecules and the aromatic rings of the L ligands [centroid-centroid distance = 3.821 (2) Å].
5-Bromo-2-(thiophen-2-yl)-1-(thiophen-2-ylmethyl)-1H-benzimidazole

There are two independent molecules in the asymmetric unit of the title compound, C16H11BrN2S2. In the crystal, weak C—H⋯N hydrogen bonds and C—H⋯thiophene ring interactions link the molecules into chains along [100]. The structure exhibits disorder of the 2-thiophen-2-yl substituent of one of the symmetry-unique molecules with a major:minor component ratio of 0.914 (3):0.086 (3).
4-(3-Methyl-4,5-dihydro-1H-benzo[g]indazol-1-yl)benzenesulfonamide

In the title compound, C18H17N3O2S, the aromatic ring bearing the sulfamide unit is aligned at 61.65 (1)° with respect to the pyrrole ring; its amino group forms N—H⋯N and N—H⋯O hydrogen bonds to neighboring molecules, generating sheets in the ac plane.
Bis{μ-4-chloro-N′-[(E)-1-(5-chloro-2-oxidophenyl)ethylidene]benzohydrazidato}bis[pyridinecopper(II)]

The crystal structure of the title complex, [Cu2(C15H10Cl2N2O2)2(C5H5N)2], features centrosymmetric dimers. The CuII ion is pentacoordinated in a quadratic pyramidal mode. The quadratic plane is formed by the O,O′,N-tridentate ligand and a pyridine molecule. The fifth coordination site is occupied by the O atom of another ligand showing a significantly longer Cu—O bond.
3-Amino-5-bromo-2-iodopyridine

The reaction of 3-amino-5-bromopyridine with N-iodosuccinimide in the presence of acetic acid produces the title compound, C5H4BrIN, with an iodo substituent in position 2 of the pyridine ring. The crystal structure features rather weak intermolecular N—H⋯N hydrogen bonds linking the molecules into chains along the z axis of the crystal.
(4-Methylpiperazin-1-yl)(2,3,4-trimethoxybenzylidene)amine

In the title compound, C15H23N3O3, the piperazine ring is in a slightly distorted chair conformation and is twisted from the mean plane of the benzene ring making a dihedral angle of 14.94 (6)°. The 4-methoxy substituent is almost co-planar with the benzene ring [C—C—O—C torsion angle = 5.4 (1)°], while the methoxy groups at positions 2 and 3 [C—C—O—C torsion angles of 122.6 (4) and −66.1 (4)°, respectively] are twisted away from the mean plane of the benzene ring in anticlinical and synclinical conformations, respectively. No classical hydrogen bonds or any weak intermolecular interactions are observed in the crystal structure.
(9S,13R,14R)-7,8-Didehydro-3,4,7-trimethoxy-17-methylmorphinan-6-one

The title compound, C20H25NO4, was synthesized by a Mitsunobu reaction of sinomenine [(9S,13R,14R)-7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one] with methanol. The chiral centers were unchanged during the reaction. Intramolecular C—H⋯O hydrogen bonds result in the formation of six-membered rings.
(E)-2-[(2,4,6-Trimethoxybenzylidene)amino]phenol1

There are two independent molecules in the asymmetric unit of the title compound, C16H17NO4, with similar conformations but some differences in their bond angles. Each molecule adopts a trans configuration with respect to the methylidene C=N bond and is twisted with a dihedral angle between the two substituted benzene rings of 80.52 (7)° in one molecule and 83.53 (7)° in the other. All methoxy groups are approximately coplanar with the attached benzene rings, with Cmethyl—O—C—C torsion angles ranging from −6.7 (2) to 5.07 (19)°. In the crystal, independent molecules are linked together by O—H⋯N and O—H⋯O hydrogen bonds and a π–π interaction [centroid–centroid distance of 3.6030 (9) Å], forming a dimer. The dimers are further linked by weak C—H⋯O interactions and another π–π interaction [centroid–centroid distance of 3.9452 (9) Å] into layers lying parallel to the ab plane.
7-[4-(4-Fluorophenyl)-2-methylsulfanyl-1H-imidazol-5-yl]tetrazolo[1,5-a]pyridine

The crystal structure of the title compound, C15H11FN6S, forms a three-dimensional network stabilized by π–π interactions between the imidazole core and the tetrazole ring of the tetrazolopyridineunit; the centroid–centroid distance is 3.627 (1) Å. The crystal structure also displays bifurcated N—H⋯(N,N) hydrogen bonding and C—H⋯F interactions. The former involve the NH H atom of the imidazole core and the tetrazolopyridine N atoms, while the latter involve a methyl H atom, of the methylsulfanyl group, and the 4-fluorophenyl F atom. In the molecule, the imidazole ring makes dihedral angles of 40.45 (9) and 17.09 (8)°, respectively, with the 4-fluorophenyl ring and the tetrazolopyridine ring mean plane.
1-Ethoxymethyl-5-methyl-9-phenyl-6,7,8,9-tetrahydro-1H-pyrimido[4,5-b][1,4]diazepine-2,4(3H,5H)-dione

The title compound, C17H22N4O3, comprises a 1,4-diazepine ring in a twist-boat conformation fused to a pyrimidine ring. The dihedral angle between the pyrimidine and phenyl rings is 80.8 (1)°. The crystal packing features N—H⋯O and C—H⋯O hydrogen bonds.
2-Nitro-N-(8-quinolyl)benzamide

In the title compound, C16H11N3O3, the amide group is twisted away from the quinoline ring system and nitrobenzene ring by 8.02 (1)° and 54.92 (1)°, respectively. The crystal packing is stabilized by intermolecular C—H⋯O hydrogen bonds, and π–π interactions between the quinoline ring systems of inversion-related molecules, with a centroid–centroid distance of 3.4802 (13) Å.
2,4-Bis(dimethylamino)-1,3,5-trimethyl-6-(nitrooxy)borazine

In the title compound, C7H21B3N6O3, the r.m.s. deviation of the borazine ring atoms is 0.019 Å. The dimethylamino groups are orientated at 41.80 (7) and 36.43 (7)° with respect to the borazine ring. The nitrooxy group is almost normal to the borazine ring [dihedral angle = 85.33 (14)°]. The methyl C atom trans to the NO3 group is displaced by −0.512 (3) Å from the ring plane, whereas the two ortho-methyl C atoms are displaced by 0.239 (3) and 0.178 (3) Å.
ICT and Distance Education in Nigeria: a Review of Literature and Accounts

Researchers examined the domain of open and distance education programs in Nigeria. The introduction of ICT usage, integration and diffusion has initiated a new age in educational methodologies, thus, it has radically changed traditional methods of teaching and learning patterns in the domain as well as offering contemporary learning experiences to both instructors and students. The discussions were made in terms of (a) the contexts of distance education in Nigeria (b) the role of ICT in distance education (c) the challenges facing ICT usage, integration and diffusion and (d) the need to consider and to promote long-term policies outcomes when evaluating distance education programs. The study was carried out using a qualitative research method; the uses of document materials and observation were an essential part of the instruments for data gathering. The study found that the high hope and enthusiasm for open and distance education are interfered with as the nation is faced with inadequacies in essential services and infrastructures: electricity, postal and telecommunication services and so on. However, there is an ongoing traditional development in distance education resources.
1′-(1,3-Diphenyl-1H-pyrazol-4-yl)-2′,3′,5′,6′,7′,7a’-hexahydro-1′H-dispiro[acenaphthylene-1,3′-pyrrolizine-2′,3′′-chromane]-2,4′′(1H)-dione

In the title compound, C41H31N3O3, the pyrazole and pyrrolidine rings adopt twisted conformations. The mean plane of the pyrazole ring forms dihedral angles of 9.11 (12) and 39.65 (11)° with the phenyl rings. The O atoms deviate from the mean planes of the chromene and acenaphthylene ring systems by 0.194 (15) and 0.079 (15) Å, respectively. In the crystal, molecules are linked via pairs of C—H⋯O interactions,forming inversion dimers with an R 2 2(12) ring motif.
(2E)-3-(3-Bromo-4-methoxyphenyl)-1-(pyridin-2-yl)prop-2-en-1-one

The mean planes of the benzene and pyridine rings in the title compound, C15H12BrNO2, are nearly coplanar, subtending an angle of 2.8 (8)°. The prop-2-en-1-one group is also in the plane of these rings with an N—C—C—O torsion angle of 179.6 (3)°. A weak C—H⋯Br intermolecular interaction contributes to the crystal packing, creating a chain-like structure along the a axis.
5-Fluoro-2-(4-methylphenyl)-3-methylsulfinyl-1-benzofuran

In the title compound, C16H13FO2S, the 4-methylphenyl ring makes a dihedral angle of 29.53 (4)° with the mean plane of the benzofuran fragment [r.m.s. deviation = 0.004 (1) Å]. In the crystal, molecules are linked by pairs of weak C—H⋯O hydrogen bonds, forming inversion dimers that stack along the a axis.
7-Fluoro-4-oxochromene-3-carbaldehyde

In the title compound, C10H5FO3, the chromenone ring is essentially planar, with a maximum deviation of 0.039 (1) Å. The dihedral angle between the fluoro-subsituted benzene ring and the pyran ring is 1.92 (4)°. In the crystal, molecules are connected via weak intermolecular C—H⋯O hydrogen bonds, forming supramolecular ribbons along the b axis. These ribbons are stacked down the a axis.
Tetra-μ-benzoato-bis[(6-methylquinoline)copper(II)]

In the title compound, [Cu2(C7H5O2)4(C10H9N)2], the paddle-wheel-type dinuclear complex is constructed by four bridging benzoate groups and two terminal 6-methylquinoline ligands. The asymmetric unit contains one-half of the whole molecule, and there is an inversion center at the mid-point of the Cu⋯Cu bond. The octahedral coordination of each Cu atom, with four O atoms in the equatorial plane, is completed by the N atom of the 6-methylquinoline molecule [Cu—N = 2.212 (2) Å] and by another Cu atom [Cu⋯Cu = 2.6939 (13) Å]. The Cu atom lies 0.234 Å out of the plane of the four O atoms. The molecular packing is stabilized by one intramolecular C—H⋯O as well as C—H⋯π and π–π interactions.
The development of an instrument to assess student opinions of the quality of distance education

The Development of an Instrument to Assess Student Opinions of the Quality of Distance Education. (August 2006) Elizabeth Hensleigh Chaney, B.S., The University of Alabama; M.A., The University of Alabama Chair of Advisory Committee: Dr. James M. Eddy In the past decade, there has been an enormous growth of distance education courses and programs in higher education. However, the potential of distance education is tempered by one overriding question: How do you ensure that distance education coursework and degrees are of high quality? The purpose of this study is threefold: (1) to identify quality indicators of distance education; (2) to provide implications of the identified quality indicators for health education researchers and practitioners; and, (3) to develop an instrument to assess student opinions of the quality of distance education. Dillman’s (2000) steps of pretesting and the instrument development framework in the Standards (1999) were used, and data were collected from students enrolled in four health education on-line courses during the Spring 2006 semester at Texas A&M University. MPlus (Muthen & Muthen, 2002) was used to conduct reliability and validity analyses of the instrument. The results of the study revealed common benchmarks and quality indicators that all parties deem important in designing, implementing and evaluating distance education courses and programs. Additionally, an instrument was produced that resulted in both valid and reliable scores.
Status Stunting Dengan Prestasi Belajar Pada Siswa Sekolah Dasar Di Kecamatan Sukodono Kabupaten Sidoarjo Tahun 2012

Background: The prevalence of stunting in children at District of Sidoarjo is 40.4%. In 2006 the prevalence was 23.5% and in 2010 was 29.4%. At Subdistrict of Sukodono the prevalence of stunting is 34.84%. Stunting is caused by chronic malnutrition that can lead to disorder in physical growth, brain development, optimum work capacity and health, as well as degree of concentration and intelligence which affect academic achievement. In a village at Subdistrict of Sukodono that has high prevalence of malnutrition, two of three elementary schools located in the village have the lowest result in score of National Test. High rate of stunting is feared to degrade academic achievement of elementary school children that affects quality of human resources. Objective: To assess association between stunting and academic achievement of elementary school students at Subdistrict of Sukodono District of Sidoarjo. Methods: The study was observational with cross sectional design. Location of the study was elementary schools at Subdistrict of Sukodono. The study was carried out by assessing height to identify stunting status associated with academic achievement in the subject of mathematics, Indonesian and natural sciences. Other factors observed were nutrition intake, eating pattern, education of parents, family income, number of family members, and role of parents as external variables associated with academic achievement. Results: There was statistically significant association (p=0.042 < 0.05) between stunting status and academic achievement. The result of multivariate test showed that stunting status, protein intake and duration of study statistically (p < 0.05) affected academic achievement. Conclusion: The majority of subject had normal status and most of stunting children had low academic achievement. Besides stunting status, protein intake and duration of study statistically affected academic achievement. Keywords: stunting status, academic achievement
Poly[bis[μ2-1,4-bis(1H-imidazol-1-yl)butane]dichloridonickel(II)]

The asymmetric unit of the title compound, [NiCl2(C10H14N4)2]n, consists of one Ni2+ ion which is located on an inversion center, one 1,4-bis(imidazol-1-yl)butane (bimb) and one chloride ion. The Ni2+ ion exhibits a distorted octahedral coordination environment defined by four N atoms from four bimb ligands in the equatorial plane and two chloride ions in axial positions. The bridging coordination mode of the bimb ligands leads to the formation of interpenetrating square Ni4(bimb)4 units that are arranged parallel to (001). The separation between the Ni atoms in these units is 13.740 (3) Å.
Clinical Spectrum of Flank Pain and ITS Association with Urolithiasis

Result: 54 patients presented with renal pathology in hundred patients of flank pain out of which 47 had urolithiasis and seven had renal problems such as renal abscess, renal tuberculosis and pelvic-ureteric junction obstruction. By chi-square test application, statistically highly significant association ( P = 0.0000) was seen between flank pain and urolithiasis. Main renal pathology causing flank pain was renal calculi 47% in my study. Among the urinary complaints most common complaints were of burning micturition. In my study second most common cause of flank pain, was spinal pathology 32%. X-ray showed a sensitivity of 83% in diagnosing urolithiasis in patients of flank pain. Ultrasono graphy showed a sensitivity of 91% in diagnosing urolithiasis while intravenous urogram was sensitive in 100% cases. Computed tomography was shown to have a sensitivity of 94-100%. Conclusion: Urolithiasis constituted maximum number of flank pain patients, most patients presented with burning micturition which shows the presence of infection. Second most common cause of flank pain was spinal pathology while other pathology like related with abdominal, ovarian and other also contributes in few patients.
2-Hydrazinyl-4-methyl-1,3-benzothiazole

The title compound, C8H9N3S, is almost planar (r.m.s. deviation = 0.019 Å) apart from the terminal –NH2 grouping [deviation of the N atom = 0.286 (2) Å]. In the crystal, molecules are linked by N—H⋯N hydrogen bonds, generating (001) sheets.
6-(4-Chlorophenyl)-2-isobutylimidazo[2,1-b][1,3,4]thiadiazole

In the title compound, C14H14ClN3S, the imidazo[2,1-b][1,3,4]thiadiazole system is essentially planar, with a maximum deviation of 0.006 (2) Å. The dihedral angle between the imidazo[2,1-b][1,3,4]thiadiazole and chlorophenyl rings is 5.07 (8)°. In the crystal, there are no classical hydrogen bonds but stabilization is provided by weak π–π [centroid–centroid distance = 3.5697 (11) Å] and C—H⋯π interactions.
Desempenho cognitivo em um grupo de idosos: influência de audição, idade, sexo e escolaridade

Introducao: A perda auditiva compromete a realizacao das atividades de vida diaria dos idosos e pode aumentar o risco de declinio funcional. Objetivo: Verificar o desempenho cognitivo de idosos e relaciona-lo com a presenca e o grau de perda auditiva, o sexo, a idade e a escolaridade. Metodo: Foram avaliados 33 idosos de 60 a 82 anos, sendo 20 (60,6%) do sexo masculino e 13 (39,4%) do sexo feminino. As avaliacoes realizadas incluiram audiometria tonal liminar e aplicacao do teste minimental (MMSE). Resultados: A analise dos dados permitiu verificar que, neste grupo de individuos, a idade, o sexo e a escolaridade nao influenciaram nos escores obtidos no MMSE. O unico fator que exerceu influencia no desempenho no teste foi o grau de perda auditiva. Os idosos que apresentaram limiares auditivos normais ou perda auditiva de grau leve na melhor orelha obtiveram escores significativamente superiores aos que eram portadores de perda auditiva de grau moderado ou severo. Conclusao: Concluiu-se que a presenca de perda auditiva influencia no desempenho cognitivo de idosos. O sexo, idade e escolaridade nao foram fatores determinantes de alteracao nos escores do MMSE. (AU) Introduction: Hearing loss impairs the elders' performance of daily life activities, and it may increase the risk for functional decline. Objective: To verify the elders' cognitive performance and establish its relationship with the presence and degree of the hearing loss, sex, age and education. Method: 33 elders from 60 to 82 years were assessed, and they were 20 (60.6%) men and 13 (39.4%) women. These assessments included pure-tone audiometry and the application of the minimental state examination (MMSE). Results: The data analysis made it possible to verify that age, sex, and education in this group of individuals did not affect the MMSE scores. The only influential factor on the test performance was the hearing loss degree. The elders showing normal hearing thresholds or a light hearing loss in their best ear obtained significantly higher scores than those showing a moderate to severe hearing loss. Conclusion: It was acknowledged that the presence of some hearing loss affects the elders' cognitive performance. Sex, age, and education were not change determining factors regarding the MMSE scores. (AU)
1H-1,2,4-Triazole-3-carboxamide

Planar molecules of the title compound, C3H4N4O, are organized into sheets by extensive N—H⋯O and N—H⋯N hydrogen bonding in the (101) plane of the crystal structure. These hydrogen bonds may also stabilize the molecule in the Z form. The title compound is in the amide form, as shown by the C=O bond length [1.252 (2) Å].
5-Propyl-6-(p-tolylsulfanyl)pyrimidine-2,4(1H,3H)-dione

In the title pymiridine-2,4-dione derivative, C14H16N2O2S, the dihedral angle between the six-membered rings is 66.69 (10)°. The molecule is twisted about the Cp—S (p = pyrimidine) bond, with a C—S—C—N torsion angle of −19.57 (16)°. In the crystal, adjacent molecules form inversion dimers through pairs of strong N—H⋯O hydrogen bonds, generating an R 2 2(8) ring motif. The dimers are connected into chains extending along the c-axis direction through additional N—H⋯O hydrogen bonds.
Bis(μ-3,5-difluorobenzoato)bis[(3,5-difluorobenzoato)dimethyltin(IV)]

In the dinuclear title complex, [Sn2(CH3)4(C7H3F2O2)4], the SnIV atom is chelated by two 3,5-difluorobenzoate (dfb) anions and coordinated by two methyl groups while an O atom from the adjacent dfb anion bridges the Sb atom with a longer Sb—O bond distance of 2.793 (4) Å. The complex molecule has 2 symmetry and the SnIV atom is in a distorted pentagonal–bipyramidal coordination geometry. In the crystal, molecules are connected by C—H⋯O and C—H⋯F hydrogen bonds.
1-Bromo-2-[(E)-2-nitroethenyl]benzene

In the title compound, C8H6BrNO2, the dihedral angle between the planes of the benzene ring and the nitro group is 22.99 (12)°. In the crystal, inversion dimers associated by pairs of short Br⋯O contacts [3.2319 (17) Å] occur.