Miracle-dz/UniFAR-FTUs huggingface dataset:
Increased Expression of Immature Mannose-Containing Glycoproteins and Sialic Acid in Aged Mouse Brains

Aging represents the accumulation of changes in an individual over time, encompassing physical, psychological, and social changes. Posttranslational modifications of proteins such as glycosylation, including sialylation or glycation, are proposed to be involved in this process, since they modulate a variety of molecular and cellular functions. In this study, we analyzed selected posttranslational modifications and the respective proteins on which they occur in young and old mouse brains. The expression of neural cell adhesion molecule (NCAM), receptor for advanced glycation endproducts (RAGE), as well as the carbohydrate-epitopes paucimannose and high-mannose, polysialic acid, and O-GlcNAc were examined. We demonstrated that mannose-containing glycans increased on glycoproteins in aged mouse brains and identified synapsin-1 as one major carrier of paucimannose in aged brains. In addition, we found an accumulation of so-called advanced glycation endproducts, which are generated by non-enzymatic reactions and interfere with protein function. Furthermore, we analyzed the expression of sialic acid and found also an increase during aging.
The Moderating Role of Marketing Communications in the Relationship between Supply Chain Integrations and Supply Chain Performance

Jutamat Sutduean, Andi Luhur Prianto, *Kittisak Jermsittiparsert, College of Innovative Business and Accountancy, Dhurakij Pundit University, Bangkok, Thailand, Faculty of Social and Political Science, Muhammadiyah University of Makassar, South Sulawesi, Indonesia, Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam, Faculty of Social Sciences and Humanities, Ton Duc Thang University, Ho Chi Minh City, Vietnam. a 607191030012@dpu.ac. th, luhur@unismuh.ac. id C,d Corresponding Author: kittisak.jermsittiparsert@tdtu.edu. vn
2 Definitions and Notation 2 . 1 Propagation and Unit Refutation Complete Encodings

We describe a compilation language of backdoor decomposable monotone circuits (BDMCs) which generalizes several concepts appearing in the literature, e.g. DNNFs and backdoor trees. A C-BDMC sentence is a monotone circuit which satisfies decomposability property (such as in DNNF) in which the inputs (or leaves) are associated with CNF encodings from a given base class C. We consider different base classes which consist of encodings with various propagation strength. In particular, we consider encodings which implement consistency checker (CC) or domain consistency (DC) by unit propagation, unit refutation complete (URC) and propagation complete (PC) encodings. We show that a representation of a boolean function with a C-BDMC can be transformed in polynomial time into an encoding from C for any of the classes of CNF encodings mentioned above.
Environmental determinants of public health in Scotland

s excluded due to wrong topic or intervention (n=7620) Potentially relevant abstracts identified and full text screened for inclusion criteria (n=236) Studies excluded from systematic review (n=100) -More than 50% of participants >9 years (n=60) -Treatment of obesity in clinical settings (n=40) Appropriate relevant studies included in systematic review (n=136) -Physical activity (n=48) -Diet (n=50) -Diet and physical activity (n=38)
Nerve-injury evoked changes in the innervation of the skin of the rat lower lip

The general aim of the experiments conducted for this thesis was to determine whether there are morphological changes in the innervation of the skin underlying states of neuropathic pain. More specifically, this thesis was immediately addressing the question of whether autonomic fibers sprout de novo into the upper dermis of the rat lower lip following bilateral chronic constriction injury (CCI) of the mental nerve, a purely sensory branch of the trigeminal. In addition to the main objective, we sought to determine whether and to what extent the peptidergic and non-peptidergic populations of primary afferent sensory fibres were affected following CCI. Due to the results we obtained, we also tested for any up regulation of the high-affinity NGF receptor trkA on primary afferent fibres following CCI as a possible trigger for the sprouting of both sympathetic and peptidergic fibres. Most importantly, we wanted to determine if there was a behavioural correlate to the different patterns of innervation observed by both autonomic and primary afferent fibers following CCI. %%%%Our findings indicate that 4 weeks following CCI injury of the mental nerve there is an abundant sprouting of both sympathetic and parasympathetic fibres into the upper dermis, a region of skin from which they are normally absent. In addition, we have demonstrated that peptidergic population of nociceptive fibres display a robust sprouting into the upper dermis which is maximal at the same time point as autonomic fibre migration. Interestingly however, we also demonstrate that in the epidermis, both populations of sensory fibers experience a significant decrease in density at 2 weeks post-CCI, followed by fibre re-growth at levels above those seen in sham-operated animals at 4 weeks post-CCI; however, this increase was only statistically significant for the nonpeptidergic population. Furthermore, the high-affinity NGF receptor, trkA, is up-regulated on CGRP-IR fibres with a peak at 4 weeks post CCI. Finally, we observed behavioural evidence for spontaneous pain or dysesthesiae at the time point when there is sprouting of both autonomic and sensory fibres.
Work Efficient Schedulers

The scheduling of multithreaded computations has attracted extensive research over past decades. Most of the research focused on design schedulers that are efficient in terms of runtime and space consumption, very often at the cost of performing more work than the computation itself required. This work considers a new class of schedulers, called work-efficient schedulers. Work-efficient schedulers aim to minimize extra work, measured by the total number of instructions executed by all processors due to scheduling, including idle (referred to as spinning in this work) time. Specifically, the total amount of work performed during the scheduling of a computation must be within a small constant factor of the total work of the computation. This work first presents an offline elastic scheduler that achieves the goal by dynamically scaling up or down the processors it utilizes in response to the instantaneous parallelism. We prove a runtime and total work bound for our offline elastic scheduler and show that it achieves linear speedup with respect to the number of processors, while maintaining work efficiency. This work further presents an online elastic work-stealing algorithm that aims at approximating the offline work-efficient schedulers. The elastic workstealing scheduler augments the traditional work-stealing algorithm with a lifeline forest communication structure that allows processors to respond swiftly to varying instantaneous parallelism in a distributed manner. We implemente this algorithm then evaluate its performance and work efficiency by comparing it agaist existing implementations of traditional work-stealing schedulers. Results show that 1) for highly parallel computations, our parsimonious scheduler is comparable to classic work stealing in its speedup; 2) for computations where parallelism is more limited, our parsimonious scheduler performs considerably less work. December 6, 2019 DRAFT
Phage-based Electrochemical Sensors: A Review

Phages based electrochemical sensors have received much attention due to their high specificity, sensitivity and simplicity. Phages or bacteriophages provide natural affinity to their host bacteria cells and can serve as the recognition element for electrochemical sensors. It can also act as a tool for bacteria infection and lysis followed by detection of the released cell contents, such as enzymes and ions. In addition, possible detection of the other desired targets, such as antibodies have been demonstrated with phage display techniques. In this paper, the recent development of phage-based electrochemical sensors has been reviewed in terms of the different immobilization protocols and electrochemical detection techniques.
An Adaptive User Interface Model for Contact Centres

companies to build lasting and contented customer relationships. Contact centres are the primary interaction point between a company and its customers. The contact centre agent’s (CCA’s) response time to solve problems is critical in terms of both the customer experiences and from the company’s revenue perspective. One approach to improve the CCA’s productivity is to provide them with a computer user interface (UI) that will facilitate and reduce the time used to assist customers. CCAs have different capabilities, expertise and interests and studies have provided empirical support that user performance can be increased when the computer UI characteristics match the user skill level. The focus of this research is to develop an adaptive user interface model for a contact centre that adapts the UI to the CCA’s expertise level in order to improve the CCA’s productivity.
Entering the black box of platform orchestration : a metaphoric co-evolutionary framework for platform-based ecosystems

(194 Words): Since the first empirical definition of business ecosystems (BEs), its central orchestration dynamic has been defined as co-evolutive. If the nature of the associated mechanisms is still debated, the co-evolutionary nature of inter-organizational innovation processes has been largely demonstrated. Platform-based ecosystems are characterized by a flexible and scalable architecture of cooperation designed to leverage collective intelligence. In such a context, platforms serve as a backbone for inter-organizational collaboration and facilitate interactions. But for a platform-based ecosystem to flourish inter-organizational co-evolutionary processes have to be triggered. To better understand how platform-based ecosystems achieve such goal, an empirical and theoretical characterization of the associated co-evolutionary processes is of utmost importance. However, current analogical transpositions of co-evolutionary mechanisms from biology to strategic management are still disparate and partial. To leverage our understanding of co-evolutionary mechanisms involved in biological complex adaptive systems, the application of a metaphorical transposition is necessary. The metaphorical transposition of coevolutionary mechanisms in organizational sciences enables the distinction between several mechanisms: mimicry, co-adaptation, and 3 different forms of co-evolutive mutualisms. This distinction allows a better understanding of platforms coordination processes, thus opening the way for the empirical identification of specific generative mechanisms and their related triggering factors.
Super Elastic Alloy Eyeglass Frame Design Using the ANSYS Workbench Environment

Up front analysis at the concept stages of developing a device most often result in reduced time to market and a better more efficient product development cycle. Design Modeler (1) / DesignXplorer (2) and ANSYS Structural’s super-elastic material model (3) are used in this demonstration of a design process for an eyeglass frame. This example provides an illustration of using the parametric functionality of the ANSYS Workbench environment for a highly nonlinear application. The Workbench environment can be used to perform design iterations in conjunction with material laws only available in the standard ANSYS environment. A shape memory superelastic material law was formally included in ANSYS 8.0. The material law captures the super-elastic behavior of Nitinol (4) along with its unique hysteretic response under cyclic loading. In the demonstration, the eyeglass frame is subjected to crushing and cyclic loading events. Geometric design variables are varied in an attempt to increase the frame stiffness yet keep the peak strain levels in the frame below 10% strain, which is a typical elastic limit for Nitinol. The cyclic behavior of the material is also monitored under the design load to evaluate the potential of fatigue failure. The procedure demonstrates the ease in interfacing the suite of Workbench products with geometric, material and contact nonlinear analysis problems.
Elevation Gradient Altered Soil C, N, and P Stoichiometry of Pinus taiwanensis Forest on Daiyun Mountain

Researches focused on soil carbon (C), nitrogen (N), and phosphorus (P) content and the stoichiometry characteristics along elevation gradients are important for effective management of forest ecosystems. Taking the soil of different elevations from 900 to 1700 m on Daiyun Mountain as the object, the elevation distribution of total C, N, and P in soil and their stoichiometry characteristics were studied. Also, the driving factors resulting in the spatial heterogeneity of soil stoichiometry are presented. The results show the following: (1) The average soil C and N content was 53.03 g·kg−1 and 3.82 g·kg−1, respectively. The content of C and N at high elevation was higher than that of at low elevation. Soil phosphorus fluctuated with elevation. (2) With increasing elevation, soil C:N ratio increased initially to 17.40 at elevation between 900–1000 m, and then decreased to 12.02 at elevation 1600 m. The changing trends of C:P and N:P were similar, and they all fluctuated with elevation. (3) Elevation, soil bulk density, and soil temperature were the main factors influencing the variation of soil C, N, and C:N. Soil pH and slope position were the driving factors for soil P, C:P, and N:P. The soil is rich in C and N, and has less total phosphorus on Daiyun Mountain. Raising the level of phosphate fertilizer appropriately can help to improve soil fertility and promote plant growth as well. In light of this information, in the near future, it will be necessary to conduct separation management of C, N, and P with regular monitoring systems to maintain favorable conditions for soil.
Combining Quantitative Data on Growth, Wood Density and Other Traits with SSR Markers to Evaluate Genetic Diversity and Structure in a Planted Population of Eucalyptus camaldulensis Dehn.

Eucalyptus camaldulensis Dehn. is one of the most morphologically and genetically variable Eucalyptus species. Growth, Leptocybe invasa Fisher & La Salle susceptibility, pilodyn penetration and other traits up to age 36 months were assessed in a seed source/family trial in China comprising 112 seedlots representing five natural stand and six exotic seed sources. Genetic diversity and population structure of this trial population were also analyzed using 48 simple sequence repeat (SSR) markers. The key objective was to examine whether the genomic data could provide value over information obtained from just quantitative trait data. Significant genetic variation was found among seed sources and among families within seed sources for most quantitative traits. The ratio of variance among seed sources to variance among families within seed sources, based on variances estimated from quantitative trait data, varied from 0.1% (height at 9 months) up to 75.2% (bark thickness). Equivalent ratios estimated from the AMOVA on SSR loci data were similar for height (ages 24 and 36 months) and also pilodyn penetration at 36 months, but not for 9-month height or 36-month bark thickness. From 48 SSR loci examined, the genetic differentiation coefficient (among seed sources) was 0.086, indicating low genetic differentiation among seed sources. While overall genetic diversity in the trial population examined was high, the levels within the different seed sources varied markedly. Prior to this study, genetic distances among families from the three exotic seed sources (from domesticated Indian populations) in the trial, along with their genetic distances from, and relatedness to, families from five natural stand seed sources (Australian) in the trial were unknown. The SSR loci data removed uncertainties and revealed that the exotic sources increased the breadth of genetic origins represented in the trial population—information that could not have been obtained from just the quantitative trait data.
Identification of Insider Trading Using Extreme Gradient Boosting and Multi-Objective Optimization

Illegal insider trading identification presents a challenging task that attracts great interest from researchers due to the serious harm of insider trading activities to the investors’ confidence and the sustainable development of security markets. In this study, we proposed an identification approach which integrates XGboost (eXtreme Gradient Boosting) and NSGA-II (Non-dominated Sorting Genetic Algorithm II) for insider trading regulation. First, the insider trading cases that occurred in the Chinese security market were automatically derived, and their relevant indicators were calculated and obtained. Then, the proposed method trained the XGboost model and it employed the NSGA-II for optimizing the parameters of XGboost by using multiple objective functions. Finally, the testing samples were identified using the XGboost with optimized parameters. Its performances were empirically measured by both identification accuracy and efficiency over multiple time window lengths. Results of experiments showed that the proposed approach successfully achieved the best accuracy under the time window length of 90-days, demonstrating that relevant features calculated within the 90-days time window length could be extremely beneficial for insider trading regulation. Additionally, the proposed approach outperformed all benchmark methods in terms of both identification accuracy and efficiency, indicating that it could be used as an alternative approach for insider trading regulation in the Chinese security market. The proposed approach and results in this research is of great significance for market regulators to improve their supervision efficiency and accuracy on illegal insider trading identification.
Supplementary Information: Quantum Interpolation for High Resolution Sensing

1 Quantum Interpolation: Theory & Practice 1 1.1 Theory of quantum interpolation . 1 1.2 Quantum Interpolation for Sensing . 2 1.3 Evaluating the fidelity of quantum interpolation 3 1.4 Comparison with Baker-Campbell-Hausdorff result . 4 1.5 Geometric representation of quantum interpolation . 4
Reply: HPV in focal cortical dysplasia

We thank Thom and colleagues for their letter addressing human papilloma virus (HPV) in focal cortical dysplasia (FCD) and other epilepsy-associated brain pathologies. They suggest that what was previously reported as the HPV E6 oncoprotein in FCDIIB is “a cross-reaction with an as-yet unidentified neuroglial protein. ” We appreciate their findings, because validation or refutation of the previous findings of HPV in FCD and glioblastoma has important public health relevance. However, several issues limit the conclusions of Thom et al, including a very small sample size, a limited description of experimental methods, incomplete experimental approaches to validate their claims, and most importantly, a failure to identify the proposed neuroglial protein. Furthermore, their report does not adequately explain the detection of the HPV viral capsid protein L1 in FCD. If the E6 oncoprotein detection is artifactual or nonpathogenic, then L1 should not be detected, because L1 and E6 are entirely nonhomologous proteins encoded by distinct genes in the HPV genome. It is puzzling that both L1 and E6 would be expressed in FCD as experimental artifact. The theory that an in utero viral infection plays a pathogenic role in brain malformations is not new and there is evidence, for example, that cytomegalovirus can cause pachygyria and smaller focal malformations. As we stated previously, the detection of E6 suggests an association between HPV and FCD but does not prove HPV pathogenicity in FCD, and further comprehensive studies are warranted to critically assess existing data sets. Until adequately powered studies are published, we stand by our original report.
Phase 2 study of cobimetinib in combination with vemurafenib in active melanoma brain metastases (coBRIM-B).

TPS9088 Background: Significant advances in the management of melanoma have improved the prognosis and overall survival of patients (pts) with metastatic disease. However, pts with active melanoma brain metastases (MBM) have been excluded from large Phase III trials and overall prognosis remains poor. Resistance to BRAF inhibitors (BRAFi) has been associated with reactivation of MAPK pathway and combination with MEK inhibitors (MEKi) has shown synergy and delays resistance. Cobimetinib is a potent MEK 1/2 inhibitor. In pts without MBM, the combination of vemurafenib + cobimetinib has improved response rates and PFS as compared to vemurafenib. Single agents BRAFi are safe to administer in pts with MBM resulting in objective intracranial responses. We aim to improve the outcomes of pts with MBM by assessing the clinical benefit of combination BRAFi/MEKi (vemurafenib + cobimetinib) in this population. Methods: This is a multi-center single arm, open label, Simon 2-stage Phase 2 study to determine the safety .
Racial Difference in the Use of VA Health Services

We study the factors that affect the utilization of health care services administered by the Department of Veterans Affairs (VA) and its racial differences. Due to data limitation, previous research in this regard mostly only focuses on veterans who are VA users or at least eligible for VA services. We fill in the gap in literature with a random sample of veterans 51 and older from the Health and Retirement Study. We find that, among all veterans, those who are black and less healthy are more likely to use VA health services. These factors, nevertheless, are no longer statistically significant after the sample is restricted to veterans who are eligible for VA services. We also find that VA health services and services provided through other channels are at least partial substitutes: VA usage drops when a veteran becomes age eligible for Medicare or when a veteran has health insurance coverage through employment. This drop in usage holds not only among all veterans, but also among veterans eligible for VA services. Finally, perception about the quality of services delivered in VA versus non-VA facilities strongly predicts VA services usage. Those who have favorable views toward VA use VA services more, and the results from variance decomposition suggests a majority part of the racial difference in VA usage can be attributed to the racial difference in such perception.
Corrections

The News story ‘How Trump’s science cuts could hurt his supporters’ (Nature 545, 273–274; 2017) misstated the number of advanced manufacturing institutes funded by the US government — there are 14, not 9. The graphic also gave the funding amounts in US$ instead of millions of US$. The News Feature ‘The electric cure’ (Nature 545, 20–22; 2017) erroneously stated that Kevin Tracey initiated the first trial for vagus nerve stimulation in humans.
Psychiatric Diagnoses and Gender Differences in Patients Admitted for Pesticide Suicide: An 11-year Retrospective Study in a General Hospital in Taiwan

目的：雖然在台灣，農藥中毒是一種常見的自殺方法，然而相關的精神科診斷及性別差異仍待研究。 方法：我們執行一項針對以農藥中毒之自殺方法而住院的病人的病歷回溯性研究，時間為2000至2011年。 針對有接受精神科照會的病病人，收集DSM-IV診斷、人口學資料、臨床資料、自殺當時的生活壓力等變數，進而分析。 結果：在177位病人中，大多數(77%)以有機磷中毒方式自殺；憂鬱症佔58%，物質使用疾患佔35%，適應障礙佔28%。 男女性別比為2。 相較於女性，男性有較多的物質使用疾患，特別是酒精使用疾患(p ＜ 0.01)。 主要的生活壓力事件為疾病、伴侶衝突、失業、親子衝突、及經濟壓力。 在生活壓力事件當中，男性有較多的失業，女性有較多的伴侶衝突(p ＜ 0.05)。 結論：以農藥中毒之自殺方法而住院的病人當中，在人口學資料及精神科診斷方面有性別的差異。 因此，自殺風險的評估及防治應考慮性別因素。
Whatever Will Be, Will Be!

A）will和won’t可以用来谈论意图和作对未来的预测。 B）What will life be like in the year 22007请用下面所给线索，仿照例句写出完整的句子。 1. children / use books -- computers