Miracle-dz/UniFAR-FTUs huggingface dataset:
Niche Modeling of Economically Important Mahanarva (Hemiptera, Cercopidae) Species in South and Central America: Are Brazilian Spittlebug Sugarcane Pests Potential Invaders of South and Central America?

Abstract Mahanarva fimbriolata, Mahanarva spectabilis, Mahanarva liturata, and Mahanarva posticata (Hemiptera: Cercopidae) are known pests in South American sugarcane and pasture plantations. They cause phytotoxicity by feeding directly from plant sap, greatly decreasing their production. In this work, we applied Species Distribution Modeling using the Maxent algorithm to analyze these four spittlebug species possible occurrence in South and Central America. Therefore, current and future bioclimatic variables, as well as elevation and other agricultural variables, were used within RStudio. Future climatic variables were differentiated between the years 2050 and 2070 with several representative concentration pathways. Overall, the species showed various suitable habitats in different countries of South and Central America. Nevertheless, when compared with future climate analysis, the number of suitable habitats is declining due to climate change. Elevation, isothermality, and different precipitation variables were mainly responsible for the results. We were able to analyze that spittlebug populations are not limited by temperature, but rather by other abiotic factors, such as precipitation.
Diverging Effects of Landscape Factors and Inter-Row Management on the Abundance of Beneficial and Herbivorous Arthropods in Andalusian Vineyards (Spain)

Land use at landscape and field scales can increase the diversity and abundance of natural enemies for pest control. In this study, we investigated interactions between landscape elements (semi-natural vegetation, olive orchards, vineyards, other agricultural areas) and inter-row management (vegetation cover vs. bare soil) in relation to arthropod populations in Andalusian vineyards. Arthropods were collected from grapevine foliage in 15 vineyards using suction sampling. Landscape structure was analyzed within a 750 m radius surrounding the studied vineyards. Arthropods were categorized into functional groups (predators, parasitoids, herbivores), and their responses to the most influencing factors were analyzed by likelihood methods and model selection. Of the total of 650 arthropods collected, 48% were predators, 33% herbivores and 19% parasitoids. Numbers of predatory aeolothrips, parasitoids and herbivorous cicadas in the study vineyards decreased with an increased proportion of vineyards in the surroundings. Spider populations in vineyards increased with increasing proportions of other agricultural fields (non-flowering crops) in the surroundings. Semi-natural elements and olive orchards had no influence on the abundance of collected arthropods. We observed synergistic effects between landscape elements and inter-row management. The total numbers of arthropods, herbivores and parasitoids in vineyards benefitted from inter-row vegetation, while spiders benefitted from bare soil. Our findings underline the importance of both surrounding landscape elements and vineyard ground cover management to promote beneficial arthropods for potential natural pest control.
TIP-B1 promotes kidney clear cell carcinoma growth and metastasis via EGFR/AKT signaling

Kidney clear cell carcinoma (KIRC) is the most prevalent kidney malignancy. Accumulating evidence shows that high expression of TIP-B1 correlates with development of tumor progression. However, the detailed functions of TIP-B1 in the KIRC remain to be further elucidated. Here, we firstly found TIP-B1 expression was significantly increased in KIRC compared with adjacent normal tissues. What’s more, higher expression of TIP-B1 were correlated with aggressive clinico-pathological characteristics. In vitro assay found TIP-B1 knockdown dramatically inhibited KIRC cells proliferation, migration and invasion. In vivo assay found down regulated TIP-B1 could suppress tumor growth and metastasis. Mechanism analysis indicated that TIP-B1 could bind EGFR and suppress EGFR degradation, then promoted EGF-induced AKT signaling. Together, TIP-B1 could be applied as an independent risk factor to predict KIRC progression and metastasis. Targeting TIP-B1 might be a new potential therapeutic strategy for KIRC treatment.
Intervening Effects of Orthostatic Blood Pressure Change on Subcortical Atrophy and Cognition in De Novo and Drug-Naïve Parkinson's Disease.

BACKGROUND Cognitive impairment and cardiovascular dysautonomia are two major non-motor features of Parkinson's disease (PD). They have been investigated separately and extensively, but their interactive outcomes have rarely been studied. OBJECTIVE The purpose of this study was to examine the association between central atrophy and cognition and to assess the influence of cardiovascular lability on this association in PD patients. METHODS Out of 151 early PD patients, 47 subjects were ultimately enrolled according to our selection criteria. Their cognitive status was examined by comprehensive neuropsychological tests assessing five domains of cognition. Supine and orthostatic blood pressures were recorded during head-up tilt tests, and orthostatic mean arterial pressure change was calculated. Every patient underwent brain magnetic resonance imaging, and intercaudate nucleus ratio was obtained as a central atrophy surrogate marker. The associations and interactions between central atrophy, cognition, and blood pressure variability were analyzed. RESULTS Among 47 subjects, 20 (42.6%) had orthostatic hypotension. Attention/working memory, executive function, and delayed recall were inversely associated with central atrophy (r = -0.332, p = 0.028; r = -0.314, p = 0.038; r = -0.399, p = 0.024; respectively). In a multiple regression model, only attention/working memory was independently associated with central atrophy when modulated by orthostatic mean arterial pressure change (p < 0.05). CONCLUSION This study revealed that cardiovascular dysautonomia interacted with the inverse association between cerebral atrophy and cognition, and it reinforced its relationship. Interaction between these two non-motor features should be kept in mind in clinical practice, particularly in PD patients with co-morbid vascular factors.
Genetic increases in olfactory bulb BDNF do not enhance survival of adult-born granule cells.

Adult-born neurons produced in the dentate gyrus subgranular zone (SGZ) develop as excitatory hippocampal granule cells (GCs), while those from the subventricular zone (SVZ) migrate to the olfactory bulb (OB), where most develop as GABAergic olfactory GCs. Both types of neurons express TrkB as they mature. Normally ~50% of new olfactory GCs survive, but survival declines if sensory drive is reduced. Increases in endogenous brain-derived neurotrophic factor (BDNF) in hippocampus, particularly with wheel running, enhance dentate GC survival. Whether survival of new olfactory GCs is impacted by augmenting BDNF in the OB, where they mature and integrate, is not known. Here we determined if increasing OB BDNF expression enhances survival of new GCs, and if it counters their loss under conditions of reduced sensory activity. Neurogenesis was assessed under normal conditions, and following unilateral naris occlusion, in mice over-expressing BDNF in the granule cell layer (GCL). OB BDNF levels were significantly higher in transgenic mice compared to controls, and this was maintained following sensory deprivation. Bromodeoxyuridine (BrdU) cell birth dating showed that at 12-14 days post-BrdU, numbers of new GCs did not differ between genotypes, indicating normal recruitment to the OB. At later intervals, transgenic and control mice showed levels of GC loss in deprived and non-deprived animals that were indistinguishable, as was the incidence of apoptotic cells in the GCL. These results demonstrate that, in contrast to new dentate GCs, elevations in endogenous BDNF do not enhance survival of adult-born olfactory GCs.
A Systematic Review and Meta-Analysis of Direct Objective Measures of Situation Awareness: A Comparison of SAGAT and SPAM

Objective To examine evidence of sensitivity, predictiveness, and methodological concerns regarding direct, objective measures of situation awareness (SA). Background The ability to objectively measure SA is important to the evaluation of user interfaces and displays, training programs, and automation initiatives, as well as for studies that seek to better understand SA in both individuals and teams. A number of methodological criticisms have been raised creating significant confusion in the research field. Method A meta-analysis of 243 studies was conducted to examine evidence of sensitivity and predictiveness, and to address methodological questions regarding Situation Awareness Global Assessment Technique (SAGAT), Situation Present Assessment Technique (SPAM), and their variants. Results SAGAT and SPAM were found to be equally predictive of performance. SPAM (64%) and real-time probes (73%) were found to have significantly lower sensitivity in comparison to SAGAT (94%). While SAGAT was found not to be overly memory reliant nor intrusive into operator performance, SPAM resulted in problems with intrusiveness in 40% of the studies examined, as well as problems with speed-accuracy tradeoffs, sampling bias, and confounds with workload. Concerns about memory reliance, the utility of these measures for assessing Team SA, and other issues are also addressed. Conclusion SAGAT was found to be a highly sensitive, reliable, and predictive measure of SA that is useful across a wide variety of domains and experimental settings. Application Direct, objective SA measurement provides useful and diagnostic insights for research and design in a wide variety of domains and study objectives.
Genetic characterization of Angiostrongylus larvae and their intermediate host, Achatina fulica, in Thailand

Angiostrongyliasis is a parasitic disease caused by nematodes of the genus Angiostrongylus. Distribution of this worm corresponds to the dispersal of its main intermediate host, the giant African land snail Achatina fulica. Genetic characterization can help identify parasitic pathogens and control the spreading of disease. The present study describes infection of A. fulica by Angiostrongylus, and provides a genetic outlook based on sequencing of specific regions. We collected 343 land snails from 22 provinces across six regions of Thailand between May 2017 and July 2018. Artificial digestion and Baermann’s technique were employed to isolate Angiostrongylus larvae. The worm and its intermediate host were identified by sequencing with specific nucleotide regions. Phylogenetic tree was constructed to evaluate the relationship with other isolates. A. fulica from Chaiyaphum province was infected with A. cantonensis, whereas snails collected from Phrae and Chiang Rai provinces were infected with A. malaysiensis. The maximum likelihood tree based on 74 A. fulica COI sequences revealed monophyletic groups and identified two haplotypes: AF1 and AF2. Only AF1, which is distributed in all regions of Thailand, harbored the larvae of A. cantonensis and A. malaysiensis. Two mitochondrial genes (COI and cytb) and two nuclear regions (ITS2 and SSU rRNA) were sequenced in 41 Angiostrongylus specimens. The COI gene indicated that A. cantonensis was closely related to the AC10 haplotype; whereas the cytb gene revealed two new haplotypes: AC19 and AC20. SSU rRNA was useful for the identification of A. cantonensis; whereas ITS2 was a good genetic marker for differentiating between A. cantonensis and A. malaysiensis. This study provides genetic information about the parasite Angiostrongylus and its snail intermediate host. The data in this work may be useful for further study on the identification of Angiostrongylus spp. , the genetic relationship between intermediate host and parasite, and control of parasites.
HDAC3 Activity is Essential for Human Leukemic Cell Growth and the Expression of β-catenin, MYC, and WT1

Therapy of acute myeloid leukemia (AML) is unsatisfactory. Histone deacetylase inhibitors (HDACi) are active against leukemic cells in vitro and in vivo. Clinical data suggest further testing of such epigenetic drugs and to identify mechanisms and markers for their efficacy. Primary and permanent AML cells were screened for viability, replication stress/DNA damage, and regrowth capacities after single exposures to the clinically used pan-HDACi panobinostat (LBH589), the class I HDACi entinostat/romidepsin (MS-275/FK228), the HDAC3 inhibitor RGFP966, the HDAC6 inhibitor marbostat-100, the non-steroidal anti-inflammatory drug (NSAID) indomethacin, and the replication stress inducer hydroxyurea (HU). Immunoblotting was used to test if HDACi modulate the leukemia-associated transcription factors β-catenin, Wilms tumor (WT1), and myelocytomatosis oncogene (MYC). RNAi was used to delineate how these factors interact. We show that LBH589, MS-275, FK228, RGFP966, and HU induce apoptosis, replication stress/DNA damage, and apoptotic fragmentation of β-catenin. Indomethacin destabilizes β-catenin and potentiates anti-proliferative effects of HDACi. HDACi attenuate WT1 and MYC caspase-dependently and -independently. Genetic experiments reveal a cross-regulation between MYC and WT1 and a regulation of β-catenin by WT1. In conclusion, reduced levels of β-catenin, MYC, and WT1 are molecular markers for the efficacy of HDACi. HDAC3 inhibition induces apoptosis and disrupts tumor-associated protein expression.
DNA Methylation Profiling Identifies Distinct Clusters in Angiosarcomas

Purpose: DNA methylation profiling has previously uncovered biologically and clinically meaningful subgroups within many tumor types, but was not yet performed in angiosarcoma. Angiosarcoma is a rare sarcoma with very heterogeneous clinical presentations, which may be based on differences in biological background. In this exploratory study, DNA methylation profiling of 36 primary angiosarcoma samples from visceral, deep soft tissue, radiation-induced, and UV-induced localizations was performed. Experimental Design: Primary angiosarcoma formalin-fixed paraffin-embedded samples from visceral, soft tissue, radiation-induced, and UV-induced origin were collected from a nationwide search for angiosarcoma in the Netherlands. DNA was extracted for methylation profiling with the Illumina Infinium MethylationEPIC array. Quality control assessment and unsupervised hierarchical clustering were performed. Copy-number profiles were generated and analyzed for chromosomal stability. Clinical data were obtained from the Netherlands Cancer Registry. Results: DNA methylation profiling by unsupervised hierarchical clustering of 36 angiosarcoma samples (6 visceral, 5 soft tissue, 14 radiation-induced, 11 UV-induced) revealed two main clusters (A and B), which were divided into four subclusters. The clusters largely corresponded with clinical subtypes, showing enrichment of UV-induced cases in cluster A1 and radiation-induced cases in cluster A2. Visceral and soft tissue cases almost exclusively fell into cluster B. Cluster A showed significantly increased chromosomal instability and better overall survival (22 vs. 6 months, P = 0.046) compared with cluster B. Conclusions: In this novel methylation profiling study, we demonstrated for the first time four different angiosarcoma clusters. These clusters correlated with clinical subtype, overall survival, and chromosomal stability.
Predictions on High-Powerful Trivalent Metal Pentazolate Salts.

High-energy-density materials (HEDMs) have been intensively studied for their significance in fundamental sciences and practical applications. Here, using the molecular crystal structure search method based on first-principles calculations, we have predicted a series of metastable energetic trivalent metal pentazolate salts MN15 (M= Al, Ga, Sc, and Y), which can be synthesized above 40 GPa and quenched to ambient pressure. These compounds have high energy densities with the highest nitrogen content among the studied nitrides so far. Pentazolate N5- molecules stack up face-to-face and form wave-like patterns in the C2221 and CC symmetries. The strong covalent bonding and very weak non-covalent interactions with non-bonded overlaps coexist in these ionic-like structures. We find MN15 molecular structures are mechanically stable up to high temperature (~1000 K) and ambient pressure. More importantly, these trivalent metal pentazolate salts have high detonation pressure (~80 GPa) and velocity (~12 km/s). Their detonation pressures exceeding that of TNT and HMX, make them good candidates for high-brisance green energetic materials.
Astrocyte–microglial association and matrix composition are common events in the natural history of primary familial brain calcification

Primary familial brain calcification (PFBC) is an age‐dependent and rare neurodegenerative disorder characterized by microvascular calcium phosphate deposits in the deep brain regions. Known genetic causes of PFBC include loss‐of‐function mutations in genes involved in either of three processes—platelet‐derived growth factor (PDGF) signaling, phosphate homeostasis or protein glycosylation—with unclear molecular links. To provide insight into the pathogenesis of PFBC, we analyzed murine models of PFBC for the first two of these processes in Pdgfbret/ret and Slc20a2−/− mice with regard to the structure, molecular composition, development and distribution of perivascular calcified nodules. Analyses by transmission electron microscopy and immunofluorescence revealed that calcified nodules in both of these models have a multilayered ultrastructure and occur in direct contact with reactive astrocytes and microglia. However, whereas nodules in Pdgfbret/ret mice were large, solitary and smooth surfaced, the nodules in Slc20a2−/− mice were multi‐lobulated and occurred in clusters. The regional distribution of nodules also differed between the two models. Proteomic analysis and immunofluorescence stainings revealed a common molecular composition of the nodules in the two models, involving proteins implicated in bone homeostasis, but also proteins not previously linked to tissue mineralization. While the brain vasculature of Pdgfbret/ret mice has been reported to display reduced pericyte coverage and abnormal permeability, we found that Slc20a2−/− mice have a normal pericyte coverage and no overtly increased permeability. Thus, lack of pericytes and increase in permeability of the blood–brain barrier are likely not the causal triggers for PFBC pathogenesis. Instead, gene expression and spatial correlations suggest that astrocytes are intimately linked to the calcification process in PFBC.
Desmoplastic Infantile Ganglioglioma: A MAPK Pathway-Driven and Microglia/Macrophage-Rich Neuroepithelial Tumor.

MAPK pathway activation has been recurrently observed in desmoplastic infantile ganglioglioma/astrocytoma (DIG/DIA) with reported disproportionally low mutation allele frequencies relative to the apparent high tumor content, suggesting that MAPK pathway alterations may be subclonal. We sought to expand the number of molecularly profiled cases and investigate if tumor cell composition could account for the observed low mutation allele frequencies. Molecular (targeted neuro-oncology next-generation sequencing/RNA sequencing and OncoScan microarray) and immunohistochemical (CD68-PGM1/CD163/CD14/CD11c/lysozyme/CD3/CD20/CD34/PD-L1) studies were performed in 7 DIG. Activating MAPK pathway alterations were identified in 4 (57%) cases: 3 had a BRAF mutation (V600E/V600D/V600_W604delinsDQTDG, at 8%-27% variant allele frequency) and 1 showed a TPM3-NRTK1 fusion. Copy number changes were infrequent and nonrecurrent. All tumors had at least 30% of cells morphologically and immunophenotypically consistent with microglial/macrophage lineage. Two subtotally resected tumors regrew; 1 was re-excised and received adjuvant treatment (chemotherapy/targeted therapy), with clinical response to targeted therapy only. Even with residual tumor, all patients are alive (median follow-up, 83 months; 19-139). This study further supports DIG as another MAPK pathway-driven neuroepithelial tumor, thus expanding potential treatment options for tumors not amenable to surgical cure, and suggests that DIG is a microglia/macrophage-rich neuroepithelial tumor with frequent low driver mutation allele frequencies.
Real-time dangerous objects detection in millimeter wave images

Millimeter wave imaging technology has been used in human body security inspection in public. Comparing to traditional X-ray imaging, it is more efficient and without harm to human body. Thus an automatic dangerous objects detection for millimeter wave images is useful to greatly save human labor. However, due to technology limitation, millimeter wave images are usually low resolution and with high noise, thus the dangerous objects hidden in human body are hard to be found. In addition, the detection speed is of great significance in practice. This paper proposes an efficient method for dangerous objects detection for millimeter wave images. It is based on a single unified CNN (Convolutional Neural Network). Compared to traditional region-based method like RCNN, by setting some default anchors over different aspect ratios at the last feature map, it is able to frame object detection as a regression problem to these anchors while predicting class probabilities. The model gets 70.9 mAP at 50 frames per second in millimeter wave images dataset, obtaining better performance than other method, showing a promise in practical using in the future.