Miracle-dz/UniFAR-FTUs huggingface dataset:
Molekulare Analyse der zellulären Funktionen der p21-aktivierten Kinase Mushroom bodies tiny von Drosophila melanogaster

The establishment, maintenance and modulation of cell-cell contacts is of crucial importance during the development of multicellular organisms to built complex tissues by means of cell sorting processes, cell movement and changes in cell morphology. Consequently, aberrant changes in the cells ́ adhesive properties can result in pathological conditions such as cancer formation. Adherens junctions provide the mechanical strength to cell-cell contacts and consist of classic cadherins, which undergo homophilic, Ca2+ dependent connections between cells (Gumbiner, 2005; Perez-Moreno and Fuchs, 2006; Perez-Moreno et al., 2003). The cytoplasmic tail of cadherins is anchored to the underlying actin cytoskeleton via members of the catenin family. β-Catenin and its Drosophila homologue Armadillo, in addition to their role in the Wnt (Wingless in Drosophila) signalling pathway, serve as molecular adaptors between cadherins and α-catenin, which is linked directly or indirectly to the actin cytoskeleton. However, recent data question the existence of a stable quaternary complex and instead show that α-catenin acts as a molecular switch: monomeric α-catenin is a structural component of the cadherin-catenin complex (CCC) and does not interact with actin whereas dimeric α-catenin regulates actin filament organization (Drees et al., 2005; Yamada et al., 2005). On the other hand, β-catenin/ Armadillo is subject to a complex (and not completely deciphered) pattern of phosphorylation by tyrosine and serine/threonine kinases to regulate its diverse function in cell adhesion and Wnt/Wg signalling. Degradation of cytoplasmatic β-catenin/Armadillo is induced by Phosphorylation by tyrosine and serine/threonine kinases regulates the interactions between cadherin, β-catenin and α-catenin and thus can influence the dynamic modulation of cell adhesion under normal and disease conditions. Previous studies suggested an involvement of p21-activated kinases (PAKs) in the regulation of cadherin mediated cell adhesion, but the molecular mechanism remained elusive. We have addressed this question using the Drosophila PAK protein Mbt, which has a function to maintain adherens junctions during eye development. Activation of Mbt results in phosphorylation of the Drosophila β-catenin (Armadillo), which in turn leads to destabilization of the DE-cadherin-Armadillo interaction. Laser tweezer experiments revealed a decrease in DE-cadherin mediated adhesion in the presence of activated Mbt. These findings support the previous observation that activation of the human Mbt homologue PAK4 leads to anchorage independent growth and provide the first molecular link between a PAK protein and the cadherin-catenin complex.
Significant proportion of the french coastal endemic Bluethroat (Cyanecula svecica namnetum) discovered in a Bluethroat population wintering in the Sidi Moussa-Walidia complex (Morocco) Proportion significative de Gorgebleues à miroir endémiques des côtes françaises (Cyanecula svecica namnetum) 

In order to start to document the potential importance of north west african coastal marshes for the wintering of the French coastal endemic Bluethroat (Cyanecula svecica namnetum), we carried out a ringing campaign in the Sidi Moussa-Walidia complex, a 10,000 hectares Ramsar site, located in the Moroccan Atlantic coast, over ten days of winter 2015-2016. Analysis of capture data with a nonparametric bootstrap resampling method revealed within the wintering Bluethroat population sampled a minimal mean proportion estimated at 38% of individuals belonging to Cyanecula svecica namnetum subspecies (17 54% within the 95% CI). Thanks to data collected for the first time in North Africa over a limited spatial and temporal scale, despite a small data set, our results confirm: 1) the potential significant proportion of C. s. namnetum among Bluethroat populations wintering in North African coastal wetlands and 2) the particular attention that should be given to North African grounds for a better consideration of threats to populations belonging to this subspecies of conservation concern given its restricted range and numbers and its dependence on Atlantic coastal wetlands.
KONA Powder and Particle Journal No. 33 (2016) 33–47/Doi:10.14356/kona.2016010

Magnetic nanoparticles provide a unique nanosystem for various smart therapy applications because of their biocompatibility, their nanostructures which can be prepared controllably to match with the interest of study and, specifically, their responses to an external magnetic field. Interests in utilizing magnetic nanoparticles for biomedical treatments originate from their external controllability of transportation and movement inside biological objects and magnetic heat generation which provide tremendous advantages for targeted drug delivery and controlled drug release as well as magnetic hyperthermia. Recent progress in synthesis and functionalization has led to the formation of various functional magnetic nanoparticles with controlled magnetic properties based on controlling their particle size, shape and composition. In this review, we focus on the synthesis, protection and functionalization of iron oxide-based magnetic nanoparticles in order to control magnetic properties of nanostructured systems. We also highlight the recent advances in the development of multifunctional therapeutic nanosystems combining magnetic nanoparticles and drugs as well as their superior efficacy in biomedical treatments with smart performance by including therapy and modulated drug delivery and release through magnetic heating.
Working Papers on Innovation and Space

The paper empirically investigates the economic resilience of Western German regions in the wake of the Great Recession of 2008/2009. In particular, the focus is laid on the influence of regional agglomeration economies (arising from specialization, related and unrelated variety) and the explicit subdivision of shortterm resilience into resistance and recovery. The necessity to distinguish between different factors and phases is well documented by means of the OLS regression results as all three types of agglomeration economies reveal varying, if not opposing directions of influences across the resistance and recovery phase. A pregnant example refers to regional specialization. Not only does it show a negative impact on resistance while exerting a positive influence during the recovery phase, but it is also mediated by the regional share in manufacturing workforce. This workforce reveals opposing phase-specific effects itself. Hence, ignoring the two-component structure of short-term resilience entails the risk of imprecise, if not false conclusions on the driving mechanisms stabilizing and/or destabilizing regional economies in times of crisis.
The effect of donor pretreatment with the heat shock protein-inducer geranylgeranylacetone on brain death-associated inflammation in the kidney

Background. Deceased brain dead (DBD)-derived kidney grafts have inferior transplantation outcomes compared to living donated kidneys. Factors affecting the graft quality are diminished organ perfusion, metabolic changes, and a systemic inflammatory reaction during the pathologic process of brain death. To reduce DBD-related kidney injury, we aim to increase the HSPA1A (HSP70) expression prior to the process of brain death. In this study we investigated whether geranylgeranylacetone (GGA), an HSPA1A inducer, can reduce the proinflammatory changes and improve kidney donor quality in an in vivo brain death rat model. Method. Male F344 rats (275-300g, n=15) underwent slow induction of brain death and were kept brain dead for 4 hours. We administered GGA (400 mg/kg orally) or a saline vehicle 20h and 1h prior to brain death induction. Sham-operated animals (n=14) received the same treatment. Results. At the moment of organ retrieval, the expressions of HSPA1A and other HSPs are not increased with GGA-treatment. However, kidney interleukin-6 (IL-6) mRNA levels in GGA pretreated DBD rats were lower compared to saline-treated controls. Systemic ASAT levels were also reduced by GGA, indicating decreased systemic injury. Conclusion. GGA reduces some markers for injury and inflammation during the brain death period, despite the unchanged expression of HSPA1A and kidney function at the time of organ retrieval. Thus, oral administrations of GGA appears not to be an effective treatment in DBD donors.
A study of brand identity and its impact on brand loyalty and brand equity

Brand is among the most valuable properties of an organization which its proper management can pave the ground for acquiring more market share and profitability in any industry including food industry. In this line, brand identity which is an intra-organizational factor and one of the most important discussions on marketing and brand is considered in a few studies. On this basis, present study with the purpose of studying the impact of brand identity impact on brand loyalty development and brand equity is conducted in food industry (dairy and meat products). This is a survey – type research in which questionnaire is used to collect data. In present study, Kaleh brand (Kaleh Dairy and Meat Products Company) as a well – recognized brand in Iran is selected for studying. All customers of the company in Tehran Metropolitan are selected as research statistical population and finally a sample of 476 customers was chosen. To analyze and confirm data, Structural Equations Modeling (SEM) and Confirmatory Factor Analysis (CFA) techniques are utilized. According to research findings, the impact of brand identity on both brand loyalty and brand equity in food industry was confirmed.
Water retention curves of geosynthetic clay liners

A typical geosynthetic clay liner (GCL) consists of a bentonite layer sandwiched between two geotextiles. The engineering function of a GCL is to act as a hydraulic barrier for leachate or other liquids and sometimes gases in solid waste landfill systems. As such, they are used as replacements for either compacted clay liner or geomembrane, or they are used together with the compacted clay liner and the geomembrane. The effectiveness of a GCL depends on the hydration of the bentonite layer during service. Normally the GCL is laid dry and is wetted by the underlying soil. Hence the water retention curve of the GCL is an important design parameter in a solid waste landfill system. The objective of this paper is to determine the water retention curve of one type of GCL using two experimental techniques. The water retention curve of the GCL at low suction showed more variability compared to the water retention curve of the GCL at high suction. The water retention curve of the GCL was found to be bimodal. The implication of the water retention curve on its application is also discussed. 2 MATERIALS AND METHODS
Unsupervised extraction of interpretable graph representations from multiple-object scenes

In this work we present Discrete Attend Infer Repeat (Discrete-AIR), a model for extracting interpretable object-level representation in an unsupervised way. Discrete-AIR is a Recurrent AutoEncoder with structured latent distributions containing discrete categorical distributions, continuous attribute distributions, and factorised spatial attention. We show that for efficient inference in the case of Multi-MNIST (Eslami et al., 2016) and Multi-Sprites (Matthey et al., 2017) datasets, the Discrete-AIR model needs just one categorical latent variable, one attribute variable (for Multi-MNIST only), together with spatial attention variables. We perform analysis to show that the learnt categorical distributions achieves 87.0% and 94.5% category correspondence rate for Multi-MNIST and for Multi-Sprites. We also discuss ways of constructing interpretable initial edge embedding from the object representations.
Tumor pH-responsive metastable-phase manganese sulfide nanotheranostics for traceable hydrogen sulfide gas therapy primed chemodynamic therapy

Manganese-based nanomaterials have piqued great interest in cancer nanotheranostics, owing to their excellent physicochemical properties. Here we report a facile wet-chemical synthesis of size-controllable, biodegradable, and metastable γ-phase manganese sulfide nanotheranostics, which is employed for tumor pH-responsive traceable gas therapy primed chemodynamic therapy (CDT), using bovine serum albumin (BSA) as a biological template (The final product was denoted as MnS@BSA). The as-prepared MnS@BSA can be degraded in response to the mildly acidic tumor microenvironment, releasing hydrogen sulfide (H2S) for gas therapy and manganese ions for magnetic resonance imaging (MRI) and CDT. In vitro experiments validated the pH-responsiveness of MnS@BSA at pH 6.8 and both H2S gas and •OH radicals were detected during its degradation. In vivo experiments showed efficiently tumor turn-on T1-weighted MRI, significantly suppressed tumor growth and greatly prolonged survival of tumor-bearing mice following intravenous administration of MnS@BSA. Our findings indicated that MnS@BSA nanotheranostics hold great potential for traceable H2S gas therapy primed CDT of cancer.
The D (cid:2) -property on products of (cid:2) -decomposable groups

The aim of this paper is to prove the following result: Let π be a set of odd primes. If the group G = AB is the product of two π -decomposable subgroups A = A π × A π (cid:2) and B = B π × B π (cid:2) , then G has a unique conjugacy class of Hall π -subgroups, and any π -subgroup is contained in a Hall π -subgroup (i.e
Depressive symptom profiles are differentially associated with atherosclerosis

Background – Depression increases the risk of subsequent vascular events in both cardiac and non-cardiac patients. Atherosclerosis, the underlying process leading to vascular events, has been associated with depression. This association, however, may be confounded by the somatic-affective symptoms being a consequence of cardiovascular disease. While taking into account the differentiation between somatic-affective and cognitive-affective symptoms of depression, we examined the association between depression and atherosclerosis in a community-based sample. Methods – In 1261 participants of the Nijmegen Biomedical Study (NBS), aged 50 through 70 and free of stroke and dementia, we measured the intima media thickness (IMT) of the carotid artery as a measure for atherosclerosis and we assessed depressive symptoms using the Beck Depression Inventory (BDI). Principal components analysis (PCA) of the BDI-items yielded two factors, representing a cognitive-affective and a somatic-affective symptom cluster. While correcting for confounders, we used separate multiple regression analyses to test the BDI sum score and both depression symptom clusters. Results – We found a significant correlation between the BDI sum score and the IMT. Somatic-affective, but not cognitive-affective symptoms, were also associated with the IMT. When we stratified for coronary artery disease (CAD), the somatic-affective symptom cluster significantly correlated with depression both in patients with and patients without CAD. Conclusions – The association between depressive symptoms and atherosclerosis is explained by the somatic-affective symptom cluster of depression. Subclinical vascular disease thus may inflate depressive symptom scores and may explain why treatment of depression in cardiac patients hardly affects vascular outcome.
COPD_A_207626 2485..2496

Christopher B Cooper Worawan Sirichana Eric V Neufeld 1 Michael Taylor Xiaoyan Wang Brett A Dolezal 1Exercise Physiology Research Laboratory, Departments of Medicine and Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; 2Division of Pulmonary and Critical Care Medicine, Department of Medicine, Chulalongkorn University, Bangkok, Thailand; 3eResearch Technology Inc., Philadelphia, PA, USA; 4Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine, University of California, Los Angeles, CA, USA Background: Exacerbations of chronic obstructive pulmonary disease (COPD) occur with increasing frequency as the disease progresses and account for poor health status, worse prognosis, and higher healthcare expenditure. Methods: We developed a networked system for remote physiological monitoring (RPM) at home and optimized it with statistical process control (SPC) with the goal of earlier detection of COPD exacerbations. We enrolled 17 patients with moderate to severe COPD with a mean (SD) age of 71.1 (7.2) years. We obtained daily symptom scores, treatment adherence and activity levels using a programmable device, and measured daily slow and forced spirometry (FEV1, FVC, PEF), inspiratory capacity (IC) and oxygenation (SpO2). To identify exacerbations, we developed rolling prediction intervals for FVC, FEV1, IC and SpO2 using SPC. Results: The time taken to perform daily monitoring was reduced from 12.7 (5.4) minutes to 6.5 (2.6) minutes through software refinements during the study. Adherence to forced and slow spirometry was 62.6% and 62.4%, respectively. The within-subject coefficients of variation for FEV1, PEF and IC were 12.2%, 16.2%, and 13.1%, respectively. Event rates per patient-year for exacerbations were: self-reported 0.42, 2/3 Anthonisen Criteria (AC) 0.42, modified AC 2.23, systemic corticosteroid use 0.56, and antibiotic use 0.56. Conclusion: We successfully implemented a networked system for RPM of symptoms, treatment adherence, and physiology at home in patients with COPD. We demonstrated that SPC improves the feasibility of RPM in COPD patients which may increase the likelihood of detecting COPD exacerbations.
RIESZ TYPE INTEGRATED AND DIFFERENTIATED SEQUENCE SPACES (COMMUNICATED BY FEYZI BASAR)

Let ∫ bv and d(bv) denote the spaces of integrated and differentiated sequence spaces, which introduced by [4] and ∫ bv(R) and d(bv(R)) also be matrix domain of the Riesz mean in the sequence spaces ∫ bv and d(bv). In this paper, some important properties of these spaces are studied and dual spaces of the spaces ∫ bv(R) and d(bv(R)) are determined. Finally, the classes ( ∫ bv(R) : Y ), (d(bv(R)) : Y ), (Y : ∫ bv(R)) and (Y : (d(bv(R))) of infinite matrices are characterized, where Y is any given sequence space.
Natural-Color Fancy White and Fancy Black Diamonds: Where Color and Clarity Converge

mond, we typically discuss atomic-level defects rather than inclusions—relying more on our spectrometers than our microscopes. Seldom are the diamonds distinguished not by color saturation, but by tone (neutral lightness and darkness) and transparency. Nevertheless, Fancy white and Fancy black diamonds break these rules and exist within their own special category, distinct from the other fancy-color diamonds described previously in our article series (Breeding et al., 2018; Eaton-Magaña et al., 2018a, 2018b). Fancy white diamonds, due to their scarcity as faceted stones, comparatively small size, and the lack of notable historical examples, are not well known. They are largely procured by connoisseurs. Probably the most famous of Fancy black diamonds is the Black Orlov (figure 1), a 67.50 ct cushion with a provenance dating back two centuries and, like the Hope diamond, rumored to be “cursed” (Balfour, 2009). Other famous Fancy black diamonds include the 312.24 ct Mogul-cut Spirit of de Grisogono, one of the world’s largest black diamonds, which originated from the Central African Republic. The Gruosi diamond is a 115.34 ct heart shape reportedly discovered in India, and the Korloff Noir is an 88 ct round brilliant. NATURAL-COLOR FANCY WHITE AND FANCY BLACK DIAMONDS: WHERE COLOR AND CLARITY CONVERGE
25 – Text Localization and Recognition in Images and Video

Short introductory text Nowadays, most textual information is captured by camera rather than scanner. Camera-based OCR is the technology to recognize characters captured by camera. Since camera is far handier than scanner and possible to capture various textual information in scene (such as characters on a signboard), realization of camera-based OCR will develop new applications of OCR. On the other hand, characters captured by camera are different from those in scanned documents and their recognition is very difficult due to various reasons. For example, their appearance is often distorted by perspective, complex background, blur, low-resolution, non-uniform lighting, and special decoration. In addition, their localization is also difficult because there is no prior knowledge of their location and there are many character-like non-character patterns. For the solution of those difficulties, we have to not only evolve the traditional image processing methods but also incorporate the state-of-the-art pattern recognition technologies. In addition, camera-based OCR deals with a “real-world” problem, general computer vision technologies are more and more important for OCR. This chapter introduces those problems and solution technologies to the realization of camera-based OCR.
A Novel Method for Broiler Abnormal Sound Detection Using WMFCC and HMM

Broilers produce abnormal sounds such as cough and snore when they suffer from respiratory diseases. The aim of this research work was to develop a method for broiler abnormal sound detection. The sounds were recorded in a broiler house for one week (24/7). There were 20 thousand white feather broilers reared on the floor in a building. Results showed that the developed recognition algorithm, using wavelet transform Mel frequency cepstrum coefficients (WMFCCs), correlation distance Fisher criterion (CDF), and hidden Markov model (HMM), provided an average accuracy, precision, recall, and F1 of 93.8%, 94.4%, 94.1%, and 94.2%, respectively, for broiler sound samples. The results indicate that sound analysis can be used in broiler respiratory assessment in a commercial broiler farm.
Characterization of the Brazilian vegetable brassicas production chain

ABSTRACT Brassica crops worldwide provide the greatest diversity of products used by man derived from a single genus. Collectively, leafy, flower and root vegetables can be eaten fresh, cooked and processed. The production of these vegetables in Brazil has been growing exponentially in the last decades, due to its economic importance, with major production volumes in several states and a quick monetary return for growers in areas considered of small acreage. With expansion, a number of aspects, including demands for quality and safety of these foods introduce themselves, strictly attached to the forms of production, logistics and their appearance. To meet the challenges and list the trends within the activities of different agents, a multiple case study was held in the states of Amazon, Minas Gerais, Paraná and Rio de Janeiro. Altogether, 55 stakeholders were interviewed, along with the compilation of different sources of data to characterize this productive chain. Changes in the scenario are imperative in order to maintain the activity of overcoming years, being related to cultivars adaptation, plant health, productions costs and difficulties during the establishment of crops. To overcome these adversities, a collective effort in terms of organization, technology transfer and R&D from official and private agents, technical assistance, and regional sanitary inspection is imperative, aiming, especially, in actions regarding themes like protected cultivation, mechanization/automation and adding value to products by processing and packaging, listed by stakeholders as priority.