Miracle-dz/UniFAR-FTUs huggingface dataset:
Genome-wide DNA methylation profiling predicts relapse in childhood B-cell acute lymphoblastic leukaemia

Chapin, J., Wekslezr, B. , Magro, C. & Laurence, J.(2012) Eculizumab in the treatment of refrac-tory idiopathic thrombotic thrombocytopenicpurpura. British Journal of Haematology, 157,772–774.Furlan, M. , Robles, R. , Galbusera, M. , Remuzzi,G. , Kyrle, P.A. , Brenner, B. , Krause, M. , Scharrer,I. , Aumann, V. , Mittler, U. , Solenthaler, M. &Lammle, B. (1998) von Willebrand factor-cleav-ing protease in thrombotic thrombocytopenicpurpura and the hemolytic-uremic syndrome[see comments]. The New England Journal ofMedicine, 339, 1578–1584.Kavanagh, D. & Goodship, T.H. (2010) Atypicalhemolytic uremic syndrome. Current Opinion inHematology, 17, 432–438.Noris, M. , Ruggenenti, P., Perna, A. , Orisio, S. ,Caprioli, J., Skerka, C. , Vasile, B. , Zipfel, P.F. &Remuzzi, G. (1999) Hypocomplementemia dis-closes genetic predisposition to hemolytic uremicsyndrome and thrombotic thrombocytopenicpurpura: role of factor H abnormalities ItalianRegistry of Familial and Recurrent HemolyticUremic Syndrome/Thrombotic Thrombocytope-nic Purpura. Journal of American Society ofNephrology, 10, 281–293.Noris, M. , Bucchioni, S. , Galbusera, M. , Donadelli,R. , Bresin, E. , Castelletti, F. , Caprioli, J., Brio-schi, S. , Scheiﬂinger, F. & Remuzzi, G. (2005)Complement factor H mutation in familialthrombotic thrombocytopenic purpura withADAMTS13 deﬁciency and renal involvement.Journal of American Society of Nephrology, 16,1177–1183.Reti, M. , Farkas, P., Csuka,D. ,Razso,K. , Schlamma-dinger,A. ,Udvardy,M.L. ,Madach,K. ,Domjan,G. ,Bereczki,C. ,Reusz,G.S. ,Szabo,A.J.&Prohaszka,Z. (2012) Complement activation in thromboticthrombocytopenic purpura. Journal of ThrombosisandHaemostasis,10,791–798.Ruiz-Torres, M.P., Casiraghi, F. , Galbusera, M. ,Macconi, D. , Gastoldi, S. , Todeschini, M. , Porrati,F. ,Belotti,D. ,Pogliani,E.M. ,Noris,M. &Remuzzi,G. (2005)Complementactivation:themissinglinkbetween ADAMTS-13 deﬁciency and microvascu-lar thrombosis of thrombotic microangiopathies.Journal of Thrombosis and Haemostasis, 93, 443–452.Sanchez-Corral, P., Gonzalez-Rubio, C. , Rodriguezde, C.S. & Lopez-Trascasa, M. (2004) Functionalanalysis in serum from atypical Hemolytic Ure-mic Syndrome patients reveals impaired protec-tion of host cells associated with mutations infactor H. Molecular Immunology, 41,81–84.Stahl, A.L. , Vaziri-Sani, F. , Heinen, S. , Kristoffers-son, A.C. , Gydell, K.H. , Raafat, R. , Gutierrez, A. ,Beringer, O. , Zipfel, P.F. & Karpman, D. (2008)Factor H dysfunction in patients with atypicalhemolytic uremic syndrome contributes to com-plement deposition on platelets and their activa-tion. Blood, 111, 5307–5315.Tsai, H.M. (2006) The molecular biology ofthrombotic microangiopathy. Kidney Interna-tional, 70,16–23.
Experimental Results of a Model Reference Adaptive Control Approach on an Interconnected Uncertain Dynamical System

The objective of this thesis is to show the experimental validation of recently proposed adaptive control architecture for uncertain dynamical systems. The experimental validation is conducted on a benchmark mechanical system setup composed of two carts, one actuated and one unactuated, physically interconnected through a spring. Specifically, an approach has been recently proposed to stabilize an overall interconnected system in the presence of unknown physical interconnections as well as system uncertainties in the context of model reference adaptive control. This uncertain dynamical system consists of actuated and unactuated portions physically interconnected to each other. In addition, the previous work enforces performance guarantees individually on both the actuated and unactuated portions of the interconnected system. In particular, a set-theoretic model reference adaptive control approach has been used in conjunction with linear matrix inequalities to enforce these performance guarantees that is restricting the respective system error trajectories of the actuated and unactuated dynamics inside a-priori, user defined compact sets. As stated above, the overarching contribution of this thesis is to present experimental results for the purpose of demonstrating the efficacy of the previously proposed approach on a benchmark mechanical system setup involving an actuated cart coupled with an unactuated cart through a spring in the presence of both unknown friction and unknown uncertainties. It is experimentally observed that utilizing the proposed approach stabilizes and restricts the respective system error trajectories of the interconnected system.
Anthropogenic Impacts on the Exceptional Precipitation of 2018 in the Mid-Atlantic United States

© 2019 American Meteorological Society For information regarding reuse of this content and general copyright information, consult the AMS Copyright Policy. Flash flooding surged through the old district of Ellicott City, Maryland, on 27 May 2018, turning Main Street into whitewater rapids, upending cars, destroying businesses, and leading to one death (Campbell and Rentz 2018). As of May 2019, damage from the Ellicott City f lood had cost $12 million, and the city was considering flood mitigation plans that ranged from $63 to $175 million (Logan 2019). Ellicott City was just one of 12 significant heavy precipitation and flooding events that occurred between May and September of 2018, shattering precipitation records across the region (National Weather Service 2019). Other notable events included 3 June, when eight West Virginia counties declared states of emergency after intense precipitation flooded bridges and washed out roads (Maher 2018), and 21–24 July, when historic rainfall across the Washington, D.C., Metropolitan Area and northern Baltimore County in Maryland resulted in more than a dozen highwater rescues of motorists stranded by flash flooding (Halverson and Samenow 2018). These exceptional heavy rainfall events are consistent with expectations from global warming (Pendergrass 2018) and observed increases in extreme precipitation across the broader northeastern United States (Huang et al. 2017; Hoerling et al. 2016; Frei et al. 2015). We examine the mid-Atlantic states of Pennsylvania, New Jersey, Maryland, Washington, D.C., Delaware, and West Virginia, which all experienced remarkable total and extreme (99th percentile wet days) precipitation in 2018 that contributed to flooding. For the years 1920–2018, 2018 has the highest or one of the three highest January–September total precipitation amounts at 33% and 62% of stations (Fig. 1a), respectively, and the highest or one of the three highest May–September extreme precipitation amounts at 6% and 13%, respectively (Fig. 1b). Spatially averaged, 2018 has the highest total precipitation on record (1-in-99 year event), while extreme precipitation is the fourth highest (4-in-99 year event), shown in Figs. 1c and 1d. Here, we assess the fraction of 2018 total and extreme precipitation risk attributable to anthropogenic forcing using station observations and a large ensemble of climate simulations.
Supporting refugee students in school education in Greater Western Sydney

Rarely do refugee students entering Australian schools possess the multiple forms of social, linguistic and cultural capital that are taken for granted in mainstream classrooms. While refugees of high-school age are assisted initially through Intensive English Centres (IECs), the transition from IECs to mainstream classrooms presents substantial challenges. This paper outlines the perceived impacts of a partnership program known as Refugee Action Support (RAS) that assists secondary school students, predominantly African humanitarian refugees, as they seek to make the transition from IECs to mainstream settings. Implemented by the Australian Literacy and Numeracy Foundation, the University of Western Sydney and the NSW Department of Education and Training, the program is based on school-based tutoring centres that use pre-service teachers as tutors. The paper explores the perceived effects on refugee students participating in RAS from the perspectives of teachers who assist in the coordination of the program at the various school sites.
A stable FHD display device based on BCE IGZO TFTs

In this work, the impact of the deposition process of the SiOx passivation layer on the electrical properties of the BCE IGZO TFTs has been studied. The ΔVth of the TFTs are 2.52 and -1.67 V under PBTS (60°C, 30 V) and NBITS (60°C, -30 V, 4500 nit) after 1 hour, respectively. The stability of these TFTs is verified in 32in FHD display devices, which still could display the picture properly after the 500-hour aging test at 60°C and 90% humidity. A stable FHD display device based on BCE IGZO TFTs was achieved.
Software-modeling complex for automation tests of low and medium power turbo electric tests

There are many problems connected with use of gas turbine units for electricity generation. The main problem is the gas turbine unit inefficient operation as a synchronous generator drive. To ensure the required quality of the generated electricity, which is largely determined by the nature of the transient processes of gas turbine unit, further improvement of control algorithms for automated control systems of gas turbine unit is required. In solving this problem, gas turbine unit should be considered in conjunction with other subsystems and units, for gas turbine power plants - this is, first of all, the electric generator and electric power industry in general. The process of tuning a gas turbine power plant control system is part of the test. Particularly time-consuming operations are manual tuning of the control system during experimental design and operational tests. Therefore, we propose to use a software-modeling complex, on the basis of which it is possible to obtain a neural network mathematical model of a gas turbine electro station and conduct its tests. In this case, in the process of testing the control system, the setup procedure is first performed on a mathematical model, then the settings obtained are checked using semi-bench testing, the final check of the decisions taken is carried out on a full-scale test bench, and data on the direct operation of a gas turbine power plant are also taken into account.
In Vitro Evaluation and Transplantation of Human Corneal Endothelial Cells Cultured on Biocompatible Carriers

Corneal transplantation is currently the only effective treatment option for dysfunctional corneal endothelial cells (CEC). In this study, we test in vitro the surgical potential of cultivated human corneal endothelial cells (hCEC) on human anterior lens capsule (HALC), LinkCell™ bioengineered collagen sheets of 20-µm thickness (LK20), and denuded Descemet membrane (dDM) as tissue-engineered grafts for Descemet membrane (DM) endothelial keratoplasty (DMEK) to bypass the problem of donor tissue availability. Primary hCEC cultured on all carriers formed a monolayer of tightly packed cells with a high cell viability rate (96% ± 4%). hCEC on HALC and LK20 showed unremarkable expression of zonula occludens-1 (ZO-1) and Na+/K+-adenosine triphosphatase (ATPase), while Na+/K+-ATPase expression of cells seeded on dDM was mainly cytoplasmic. All hCEC–carrier constructs were evaluated by simulating DMEK surgery in vitro using a human donor cornea without DM mounted on an artificial anterior chamber (AC) and a regular DMEK-graft used as a surgical reference model. During in vitro surgery, hCEC–HALC constructs behaved most similarly to a DMEK-graft during implantation and unfolding, showing good adhesion to the bare stroma. On the other hand, hCEC–LK20 and hCEC–dDM constructs required some additional handling because of challenges related to the surgical procedure, although they were both successfully unfolded and implanted in the artificial AC. The hCEC–dDM constructs showed similar graft adherence as hCEC–HALC constructs, while adherence of hCEC–LK20 constructs was less effective. After the in vitro surgery, the estimated area populated by viable cells on the hCEC–HALC and hCEC–LK20 constructs was ∼83% and ∼67%, respectively. Overall, hCEC–HALC constructs behaved most similarly to a DMEK-graft during in vitro DMEK surgery, while graft adhesion and surgical handling, respectively, are parameters still requiring optimization for hCEC–LK20 and hCEC–dDM constructs.
The effect of empowerment program on hemoglobin A1C in type 2 diabetes patients

زمينه و هدف: در روش هاي نوين آموزش به بيمار، موضوع توانمندسازي مطرح شده که درآن بر نقش فعال بيمار يک شاخص مهم موفقيت بيمار در کنترل ميزان (HbA1C) در آموزش تاکيد شده است. ميزان هموگلوبين گليکوزيله قند خون مي باشد. اين مطالعه به منظور تعيين تاثير برنامه توانمندسازي بر ميزان هموگلوبين گليکوزيله بيماران مبتلا به ديابت نوع دو انجام شد. مواد و روشها: اين مطالعه به صورت کارآزمايي باليني بر روي 134 بيمار مبتلا به ديابت نوع دو که به طور تصادفي به دو گروه 67 نفري مداخله و کنترل تقسيم شدند، انجام شد. ابزار پژوهش پرسشنامه مربوط به اطلاعات دموگرافيک و بود. برنامه توانمندسازي بر اساس برنامه تنظيمي در طي شش جلسه 90 A1C آزمايش خون از نظر ميزان هموگلوبين قبل و سه ماه بعد از مداخله در دو گروه اندازهگيري شد. براي A1C دقيقه اي در گروه آزمون اجرا گرديد. هموگلوبين آناليز دادهها از آزمونهاي تي مستقل، تي زوج، کاي دو، ضريب همبستگي پيرسون و آناليز واريانس در نرم افزار استفاده گرديد. SPSS17 يافتهها: بين هموگلوبين گليکوزيله گروه مداخله و کنترل قبل از مداخله اختلاف آماري معنيداري وجود نداشت. 8) و کنترل /33±1/ نتايج بيانگر اختلاف معني دار آماري در ميزان هموگلوبين گليکوزيله بين گروه مداخله ( 52 و ميانگين هموگلوبين گليکوزيله گروه مداخله بعد از اجراي (P<0/ 10/06±1/57 ) پس از اجراي مداخله بود ( 001 ) برنامه توانمندسازي کاهش پيدا کرد. نتيجهگيري: نتايج نشان داد که اجراي برنامه توانمندسازي توانسته است کارآيي بيماران را در کنترل قند
16kW single mode CW laser with dynamic beam for material processing

The principles of coherent beam combining for multiple fiber laser amplifiers is presented and discussed, with a focus on the optical phased array (OPA) beam combining technique. Several unique properties of OPA beam combining such as real time control over beam scanning, beam shape, focal plane position and intensity modulation with a MHz bandwidth open up several important new degrees of freedom for materials processing applications, enabling higher throughput, more efficient operation and advanced processing techniques. A 16kW dynamic laser beam at 1064nm based on coherent combination of 32 parallel ytterbium doped fiber amplifiers is presented, together with some example beam profiles.
The rise of the Pragmatic Web: implications for rethinking meaning and interaction

Much attention has been paid to the rise of the “Semantic Web” – a set of protocols for meanings to be shared across different platforms and systems of encoding to allow our machines to “talk” to each other. Less attention has been paid to the development of what has been called the “Pragmatic Web”, which consists of networks of tools, protocols and agents (both human and algorithmic) that interact to make and interpret meanings through actions. In some ways, however, advances in creating a “Pragmatic Web” have outstripped efforts to create a “Semantic Web”, a fact seen most clearly in the various algorithms that monitor the actions of users and transform them into inferences about the kinds of content they wish to be fed or the kinds of products they want to buy – algorithms that are at the heart of search engines like Google, recommender systems like that used by Amazon.com, and filtering systems like Facebook’s EdgeRank. The rise of the Pragmatic Web introduces challenges to scholars of pragmatics and discourse analysis, forcing us to rethink fundamental principles of meaning and interaction, including how implicature is created, how inferences are formed, the role of context in assigning meaning to action, and what constitutes a “speech act” to begin with. This chapter explores the ways digital communication involving networks of human and non-human agents is changing how we study pragmatics, and the implications of this for how we understand the social and ethical aspects of computer mediated communication.
ANALYSIS OF CURRICULUM PROCESS AND DEVELOPMENT OF A MODEL FOR SECONDARY LEVEL IN PAKISTAN

One of the most important objection educations is the socialization of the individual. School is a social agency, which is entrusted with the task of transmitting the cultural values to the coming generation. Curriculum is such a tool sued by the school to achieve these objectives. Constant effort is needed to make this tool useful and to evaluate its effectiveness. Therefore, revision and improvement in curriculum is necessary for making provision for the challenges and demands of the society. The study was aimed at analyzing the curriculum process and development of a model for secondary level in Pakistan. The major objectives of the study were; a) to explore the exiting process; b) to find out the merits; c) to explore the weaknesses; d) to obtain the opinions of the curriculum expert/teachers; and e) to develop a model of curriculum development for secondary level in Pakistan. The experts working in the Curriculum Wing, Ministry of Education, provincial Bureaus of curriculum, Textbook Boards, Boards of intermediate and secondary Education along with secondary school teaches were included in the population for the analysis purpose. Sixty-seven experts and 2200 teachers were randomly selected as sample of the study from all over the Pakistan. Questionnaires were the main instrument for data collection. Two questionnaires, one for curriculum experts/ subject specialists and the other for secondary school teachers, were developed in order to collect data. The researcher personally traveled to the target areas and also data was collected through contacts. Percentages and chi square were used for statistical treatment of the data. The suggestions made by the respondent were tabulated and calculated. Discussions, conclusions and recommendations were given in the light of analysis of the data. The model was developed on the basis of the findings of the study and was validated by the doctoral committee of the researcher and experts of the curriculum
Accelerating numerical wave propagation using wavefield adapted meshes. Part I: forward and adjoint modelling

An order of magnitude speed-up in finite-element modelling of wave propagation can be achieved by adapting the mesh to the anticipated space-dependent complexity and smoothness of the waves. This can be achieved by designing the mesh not only to respect the local wavelengths, but also the propagation direction of the waves depending on the source location, hence by anisotropic adaptive mesh refinement. Discrete gradients with respect to material properties as needed in full waveform inversion can still be computed exactly, but at greatly reduced computational cost. In order to do this, we explicitly distinguish the discretization of the model space from the discretization of the wavefield and derive the necessary expressions to map the discrete gradient into the model space. While the idea is applicable to any wave propagation problem that retains predictable smoothness in the solution, we highlight the idea of this approach with instructive 2-D examples of forward as well as inverse elastic wave propagation. Furthermore, we apply the method to 3-D global seismic wave simulations and demonstrate how meshes can be constructed that take advantage of high-order mappings from the reference coordinates of the finite elements to physical coordinates. Error level and speed-ups are estimated based on convergence tests with 1-D and 3-D models.
An Examination of the Current Status of Paraprofessionals through their Lens: Role, Training, and Supervision

Revisions of the Individuals with Disabilities Education Act (IDEA) of 1997 allowed for districts to hire teachers’ aides to assist in the educational process. These teachers’ aides, known as paraprofessionals or paraeducators, have increased in number since 1997 and now play an important role in helping students with disabilities. The purpose of the current study is to diagnose the current situation of paraprofessionals in special education within the four key aspects of appropriate role, inappropriate role, training, and supervision. A total of 47 paraprofessionals participated in the survey. Using the paraprofessionals’ perspectives on what the challenges and demanding areas were, we aim to establish a basis for providing teachers and school administrators guidelines to better support paraprofessionals who work with students with disabilities. Future research and limitations are discussed.
Patelloplasty with and without circumpatellar denervation in reducing anterior knee pain in primary total knee arthroplasty: a comparative prospective study

Background: Anterior knee pain (AKP) following total knee arthroplasty (TKA) ­­­­­­is one of the complication which cause dissatisfaction in patients. Incidence estimated to be 4-49%. The aim of our study is to know the efficacy of patelloplasty with circumpatellar denervation with diathermy in reducing AKP in primary TKA. Methods: A total of 130 unilateral TKAs’ are divided into 2 groups. Group I (control) includes 65 patients in which only patelloplasty was done. Group II (intervention) includes 65 patients in which both patelloplasty and circumpatellar denervation with diathermy was done and analysed. Mean follow up period was 18 months. Patients were assessed both preoperatively and postoperatively at final follow up. Results: The overall incidence of AKP at follow up (18 months) was 16.9%, with 7.7% in the intervention group and 26.1% in the control group (p<0.05). Western Ontario and McMaster Universities osteoarthritis index scores were significantly better in intervention group when compared to control group (28.71±3.948 vs 31.40±3.860). Better results were also found in knee society scores for intervention group compared to control group (166.57±7.941 vs 161.23±11.219); Feller patellar score of intervention group was significantly better when compared to control group (23.28±2.546 vs 20.69±3.729); the range of knee flexion was similar in both the groups (94.62±12.6 vs 93.54±10.7). In terms of pain referred by the patient at 72 hrs postoperatively, there was statistically significant difference observed according to visual analogue scale. Conclusions: There is statistically significant difference with respect to AKP in patients who have undergone patelloplasty with circumpatellar denervation using diathermy compared with patelloplasty alone.