Miracle-dz/UniFAR-FTUs huggingface dataset:
Progressive Osteolysis after Porous-Coated Anatomic (PCA) Uncemented Total Hip Arthroplasty Ten-Year Results in 32 Consecutive Cases

Thirty-two primary non-cemented first generation Porous-Coated Anatomic (PCA) total hip prostheses in 31 patients were followed prospectively. The average follow-up period was 10.3 years. The median age at surgery was 53 years (range 21–65). All operations were performed by one surgeon. Preoperatively, all cases had a poor Harris Hip Score. Ten years after surgery, 95% were rated good or excellent. Progressive roentgenographical changes were observed. In particular there was severe femoral osteolysis in zones 1, 2 and 7, and extensive wear of the polyethylene liner at the two latest follow-up examinations. Wear of the polyethylene liner, up to 0.4 mm/year, was significantly correlated with osteolysis after seven years (p=0.003). Aseptic cup loosening was the reason for six of the eight failures. At 10.3 years after surgery the survival with revision as end-point was 72%. We stopped using the 1st generation PCA prosthesis after five years due to worrying roentgenographic changes. The seven and ten years results have confirmed that this prosthesis cannot be recommended for implantation.
Frequency of neuropathic pain in type 2 diabetes mellitus at the Lagos University Teaching Hospital: A questionnaire-based outpatient survey

Background: Neuropathic pain (NP) is one of the most common complications of type 2 diabetes mellitus (DM). The frequency of NP in population living with type 2 DM is unclear. Objective: To determine the frequency of NP symptoms in patients with type 2 DM. Materials and Methods: This cross-sectional study recruited 250 type 2 DM patients attending the outpatient diabetes clinic of the Lagos University Teaching Hospital (LUTH) over a period of 4 weeks. Demographic data and data regarding current DM treatment, prior diagnosis of NP, and current treatment of NP were obtained using a structured questionnaire. Glycaemic status of the patients was assessed measuring fasting blood glucose and glycosylated hemoglobin level. Presence of NP was documented using the painDETECT questionnaire (PDQ). Results: NP was present in 54 out of the 250 type 2 DM patients studied giving a frequency of 21.6%. Out of 54 patients 36 (66.7%) were females and 18 (33.3%) were males giving a male: female ratio of 1:2 (P < 0.05). The mean age of type 2 DM patients with NP was significantly higher than the mean age of type 2 DM patients without NP (62.4 ± 10.9 years vs 58.9 ± 11.7 years; P = 0.05). Glycaemic status and disease duration did not differ among DM patients with or without NP. Only 10 out of 54 (18.5%) patients were treatment naοve at the time of study; however, out of the 44 patients receiving treatment only 9 (20.5%) were on appropriate treatment compared to international guidelines on treatment of diabetic NP. Conclusion: NP was present in 21.6% of type 2 DM patients attending the LUTH.
Microscopic and Metallurgical Studies as a Function on Forensic Investigation of Electrical Fires

Electrical wires with melted ends showing beaded, drop-shaped, and pointed shapes are frequently encountered after fires that may provide useful information on the cause and development of the fire.Various methods have been studied for differentiating between primary arcing beads, (indicating arcing as the fire cause) and secondary arcing beads (indicating arcing as a result of the fire). There are few studies carried out on the melting globules produced due to fire heat. Also, in some major cases, primary arcing beads and secondary arcing beads are difficult to be identified by using one method. In this study, a full scheme of differentiating methods between simulated samples of melting globules, primary arcing beads and secondary arcing beads are processed with macroscopic investigation. The in-depth composition of carbon quantitative analysis and metallurgical analysis of these samples have been studied. The results of this study has proved that the real cases are compatible with simulated ones.
AlSi-SiC Composites for Automotive Brake Rotor

This manuscript investigates the Fabrication and Microstructure of Automotive Brake Rotor Made of AlSi-SiC Composites. This work is oriented toward fabrication of automotive brake rotors from Al-9Si and Al-12Si reinforced with 10 and 20% SiC particles using stir-casting method. The brake rotors were subjected to heat treatment. Aging behavior showed that hardness increased with the addition of SiC reinforcements by 104%, comparing to solution treatment condition. Also, the addition of SiC particles accelerates formation of precipitates. Microstructure of brake rotors made of composite revealed uniform distribution of SiC particles, primary phase (⍺-Al) and modified eutectic Si. EDX analysis showed the presence of Al, Mg and O at the interface between matrix and SiC particles.
Manufacturing Titanium and Al-Li Alloy Cryogenic Tanks

This study presents manufacturing cryogenic tanks for aerospace applications. Since most high strength aerospace alloys like titanium alloys and Al-Li alloys exhibit low formability due to low ductility and work hardening, superplastic forming technology is applied to manufacture hemispherical shapes. Superplasticity is the ability of materials to deform plastically to show very large amount of strains. Advantages of superplastic forming technology include its design flexibility, low tooling cost and short leading time to produce. In this study, various manufacturing processes, like superplastic forming, diffusion bonding, laser beam welding and friction stir welding, are applied to manufacture titanium and aluminum cryogenic tanks. Using these technologies in manufacturing process makes the aerospace components lighter and stiffer, with efficient energy and cost saving.
Dynamic Postural Instability in Individuals with High Body Mass Index

Objective(s): To evaluate and compare static and dynamic balance between individuals with high body mass index (BMI) and normal BMI.Methods: This case-control study included 19 individuals with high BMI and 7 individuals with normal BMI. It was conducted at a regional level university setting. The center of pressure (COP) changes during double limb stance and single limb stance were obtained using a force plate (Brazil Do). The main COP outcome measures included total displacement, area of sway, amplitude, velocity, and mean power frequency changes in anteroposterior (AP) and mediolateral (ML) directions.Results: During single limb stance, there was a significant difference in COP amplitude (cm) (p=0.015) and velocity (cm/s) (p=0.012) between the 2 groups in the AP direction. However, there were no significant differences found in the ML direction for amplitude (cm) (p=0.155) or velocity (cm/s) (p=0.186). There was no significant difference in the COP outcome measure for double limb stability for both the eyes closed and eyes opened conditions.Conclusion: Individuals with high BMI have impaired dynamic balance control in the AP direction reflected through higher COP amplitude and velocity. They have preserved stability in the ML direction during single limb stance stability. The COP changes during the double limb stance are unimpaired, both with eyes opened and closed.
Anthrax Toxin as a Molecular Platform to Target Nociceptive Neurons and Modulate Pain

Bacterial toxins are able to act on neurons to modulate signaling and function. Here, we find that nociceptive sensory neurons that mediate pain are enriched in the receptor for anthrax toxins, ANTXR2. Anthrax Edema Toxin (ET) induced cAMP and PKA signaling in Nav1.8+ nociceptive neurons and modulated pain in vivo. Peripherally administered ET mediated mechanical allodynia in naïve mice and during B. anthracis infection. Intrathecally administered ET produced analgesic effects, potently blocking pain-like behaviors in multiple mouse models of inflammatory and chronic neuropathic pain. Nociceptor-specific ablation of ANTXR2 attenuated ET-induced signaling and analgesia. Modified anthrax toxin successfully delivered exogenous protein cargo into nociceptive neurons, illustrating utility of the anthrax toxin system as a molecular platform to target pain. ET further induced signaling in human iPSC-derived sensory neurons. Our findings highlight novel interactions between a bacterial toxin and nociceptors that may be utilized for developing new pain therapeutics. SUMMARY ANTXR2 expression on nociceptive neurons allows selective targeting and modulation of pain by native and engineered anthrax toxins.
Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins

Transport of LDL-derived cholesterol from lysosomes into the cytoplasm requires NPC1 protein; NPC1L1 mediates uptake of dietary cholesterol. We introduced single disulfide bonds into NPC1 and NPC1L1 to explore the importance of inter-domain dynamics in cholesterol transport. Using a sensitive method to monitor lysosomal cholesterol efflux, we find that NPC1’s N-terminal domain need not release from the rest of the protein for efficient cholesterol export. Either introducing single disulfide bonds to constrain lumenal/extracellular domains or shortening a cytoplasmic loop abolishes transport activity by both NPC1 and NPC1L1. The widely prescribed cholesterol uptake inhibitor, Ezetimibe, blocks NPC1L1; we show that interface residues that lie at the interface between NPC1L1’s three extracellular domains comprise the drug’s binding site. These data support a model in which cholesterol passes through the cores of NPC1/NPC1L1 proteins; concerted movement of various domains is needed for transfer and Ezetimibe blocks transport by binding to multiple domains simultaneously.
The HPA stress axis shapes aging rates in long-lived, social mole-rats

Sexual activity and/or reproduction doubles life expectancy in the long-lived rodent genus Fukomys. To investigate the molecular mechanisms underlying this phenomenon, we analyzed a total of 636 RNA-seq samples across 15 tissues. This analysis suggests that the differences in life expectancy between reproductive and non-reproductive mole-rats are mainly caused by critical changes in the regulation of the hypothalamic-pituitary-adrenal stress axis, which we further substantiate with a series of independent evidence. In accordance with previous studies, the up-regulation of the proteasome and several so-called “anti-aging molecules”, such as DHEA, is also linked with enhanced life expectancy. On the other hand, several our results oppose crucial findings in short-lived model organisms. For example, we found the up-regulation of the IGF1/GH axis and several other anabolic processes to be compatible with a considerable lifespan prolongation. These contradictions question the extent to which findings from short-lived species can be transferred to longer-lived ones.
Human Brain–Derived Neurotrophic Factor Gene-Modified Bone Marrow Mesenchymal Stem Cells Combined With Erythropoietin Can Improve Acute Spinal Cord Injury

Objective: To assess the effect as well as mechanism of bone marrow mesenchymal stem cells (BMSCs) modified by the human brain–derived neurotrophic factor gene combined with erythropoietin (EPO) in the treatment of acute spinal cord injury (SCI) in rats. Methods: The Brain-derived neurotrophic factor (BDNF) gene was transected by a virus vector. Rats with SCI were randomly split into following groups: The normal saline (NS) group, the EPO group, The Basso, Beattie, and Bresnahan scores, messenger RNA BDNF expression, and apoptosis rates were compared between the 4 groups at 1, 3, 7, 14, and 21 days after SCI. Results: At 7, 14, and 21 days after operation, the expression of the BDNF gene in the other 3 groups was higher than that of the NS group, and the difference was statistically significant (P < .05). The apoptosis rate in the combined group was less than that of NS, EPO, and BDNF/BMSC groups, and the differences were statistically significant (P < .05). Conclusion: Brain-derived neurotrophic factor gene-modified BMSC transplantation combined with EPO can promote the repair of nerve function after SCI in rats.
Effectiveness of interventions to improve participation outcomes for children with developmental coordination disorder: A systematic review

Introduction Developmental coordination disorder affects a child’s motor abilities and participation across environments. This study aimed to review systematically the effectiveness of interventions using a motor, cognitive or psychological approach on participation outcomes in children with developmental coordination disorder. Method A systematic review of the literature published between 2001 and November 2017 was conducted. Eight electronic databases were searched: Embase, PubMed, CINAHL, PsycINFO, the Cochrane Library, Education Full Text (H. W. Wilson databases), SPORTDiscus (all via EBSCO) and Scopus (Web of Science). Results In total, 12 studies met the inclusion criteria: seven randomised controlled trials, two quasi-experimental and three case series. Systematic quality assessment and meta-analysis was not possible given the heterogeneity of research designs, interventions and outcome measures. Limited evidence for participation outcomes was found. The cognitive orientation to daily occupational performance intervention found a between-group effect on the Canadian Occupational Performance Measure (COPM) outcome measure performance, g = 1.0 (0.02, 1.9), and COPM satisfaction, g = 1.4 (0.4, 2.3), in favour of the cognitive orientation to daily occupational performance for one randomised controlled trial. Large significant within-group effects were found for the cognitive orientation to daily occupational performance intervention on the COPM outcome measure COPM satisfaction, d = –2.1 (–5.2, –0.2). Conclusion More high-quality research is needed to strengthen the evidence base regarding occupational therapy interventions to improve participation outcomes for children with developmental coordination disorder.
Identification of Key Genes and Pathways for Enchondromas by Bioinformatics Analysis

Background: The risk of malignant transformation of enchondromas (EC) toward central chondrosarcoma is increased up to 35%, while the exact etiology of EC is unknown. The purpose of this research was to authenticate gene signatures during EC and reveal their potential mechanisms in occurrence and development of EC. Methods: The gene expression profiles was acquired from Gene Expression Omnibus database (no. GSE22855). The gene ontology (GO), protein–protein interaction (PPI) network and Kyoto Encyclopedia of Genes and Genomes pathway (KEGG) enrichment analyses were utilized to identify differentially expressed genes (DEGs). Results: Finally, 242 DEGs were appraisal, containing 200 overregulated genes and 42 downregulated genes. The outcomes of GO analysis indicated that upregulated DEGs were mainly enriched in several biological processes containing response to hypoxia, calcium ion, and negative regulation extrinsic apoptotic signaling pathway. Furthermore, the upregulated DEGs were enriched in extracellular matrix (ECM)–receptor interaction, protein processing in endoplasmic reticulum and ribosome, which was analyzed by KEGG pathway. From the PPI network, the top 10 hub genes were identified, which were related to significant pathways containing ribosome, protein processing in endoplasmic reticulum, and ECM-receptor interaction. Conclusion: In conclusion, the present study may be helpful for understanding the diagnostic biomarkers of EC.
A New Chlorinated Phenolic Compound From the Antarctic Lichen, Pertusaria dactylina

A new chlorinated phenolic compound, methyl-3-chloro-2-hydroxy-4-methoxy-6-pentylbenzoate (1) and 4 known compounds (2-5) were isolated from the Antarctic lichen, Pertusaria dactylina (Pertusariaceae). The structure of the new compound was determined by means of One-dimensional and two dimensional nuclear magnetic resonance (1D and 2D NMR) and high-resolution fast atom bombardment mass spectrometry (HRFABMS) experiments. The antimicrobial activities of compounds 1 to 5 against Staphylococcus aureus and Candida albicans were evaluated. The results showed that compound 1 exhibited a weak inhibitory effect against C. albicans with an IC50 value of 67 ± 7 μg/mL.
Personalised Medicine in New Zealand: A new approach to healthcare delivery

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Guideline summary: Intensive care admission, treatment and discharge of critically ill haemato-oncological patients

Haemato-oncological patients are often treated in the intensive care unit (ICU) because of severity of disease and treatmentrelated side effects. This guideline aims to provide advice for the admission and treatment of haemato-oncological patients in the ICU, in order to improve the quality of care. It is important not to postpone ICU treatment and once admitted a multidisciplinary evaluation of the clinical condition should take place after the first couple of days of ICU support. Furthermore, to facilitate information handover it is recommended to use a checklist at admission. Timing of endotracheal intubation is discussed, using a decision model. Optimal care includes a daily multidisciplinary meeting, specific criteria for transfusion, antibiotic prophylaxis and treatment and use of selective digestive decontamination or selective oral decontamination. A bronchoalveolar lavage does not result in a significantly higher intubation rate, but frequently provides a new diagnosis. It is also advised to use a checklist at ICU discharge and to provide an option for early consultation of the ICU or an ICU liaison nurse, in order to prevent complications after discharge.
Safe Injection Facilities in the Tenderloin: Starting with Operational Plans

There are over 90 safe injection facilities (SIFs) in at least 11 countries around the world, except in the United States. SIFs are spaces where people who inject drugs (PWID) can bring their preobtained drugs in a hygienic space and use them under supervision. The goal of these sites is to reduce the harmful effects of injection drug use and refer PWID to other medical, social, and treatment services. The Safer Inside Coalition, a community-driven health initiative, in the Tenderloin district of San Francisco recommended opening a SIF in the Tenderloin to improve the health of the community and individual drug users. The purpose of this project was to develop an operational plan for a SIF. Based on a literature review and coalition meetings, two operational plan models were developed – a centralized model and an integrated model. These were compiled in a report for community organizations to review to assess feasibility of implementing these services in the Tenderloin district. Further development needs to be done to work out more specific details based on the model that is chosen and the needs of the community.
Do Election Laws Restricting Public Road Publicity Reduce Road Traffic Crashes and Their Consequences?

Supplemental Digital Content is available in the text. Background: In April 2016, Chile enacted the Law 20,900, which restricted electoral publicity on public roads. It established two important regulations: first, candidates were allowed, 30 days before any election, to publicize their campaigns in specific street locations. Second, roadside publicity must follow strict size standards to avoid visual contamination. This article examines the impact of this regulation in reducing road traffic crashes. Methods: We obtained a number of traffic injuries and fatalities per population from public records. A time-series difference-in-difference study, using generalized linear models with an interaction between time-period and intervention, compared a municipal election period before the introduction of Law 20,900 (2012) to the first municipal election affected by the law (2016). We adjusted for precipitation and temperature, and applied models to three cities: Santiago, Gran-Valparaíso, and Concepción. We assessed the overall impact of the intervention using random effects meta-analyses. Results: The law was associated with a decrease of 0.01 (95% confidence interval [CI]: −0.02, −0.00) in Santiago, a decrease of 0.01 (95% CI: −0.03, −0.00) in Valparaíso and an increase of 0.09 (95% CI: 0.06, 0.13) in Concepción, in all daily injuries and fatalities per 100,000 population. After 40 days of its implementation, the intervention was associated with a mild absolute reduction of 34 (95% reduction interval: −270, 67) traffic injuries and fatalities. Conclusions: This study estimates that the regulation of public road publicity had an overall mild effect on reducing traffic injuries and fatalities in three large cities in Chile.
Rac1 relieves neuronal injury induced by oxygenglucose deprivation and re-oxygenation via regulation of mitochondrial biogenesis and function

Certain microRNAs (miRNAs) can function as neuroprotective factors after reperfusion/ischemia brain injury. miRNA-142-3p can participate in the occurrence and development of tumors and myocardial ischemic injury by negatively regulating the activity of Rac1, but it remains unclear whether miRNA-142-3p also participates in cerebral ischemia/reperfusion injury. In this study, a model of oxygen-glucose deprivation/re-oxygenation in primary cortical neurons was established and the neurons were transfected with miR-142-3p agomirs or miR-142-3p antagomirs. miR-142-3p expression was down-regulated in neurons when exposed to oxygen-glucose deprivation/re-oxygenation. Over-expression of miR-142-3p using its agomir remarkably promoted cell death and apoptosis induced by oxygen-glucose deprivation/re-oxygenation and improved mitochondrial biogenesis and function, including the expression of peroxisome proliferator-activated receptor-γ coactivator-1α, mitochondrial transcription factor A, and nuclear respiratory factor 1. However, the opposite effects were produced if miR-142-3p was inhibited. Luciferase reporter assays verified that Rac Family Small GTPase 1 (Rac1) was a target gene of miR-142-3p. Over-expressed miR-142-3p inhibited NOX2 activity and expression of Rac1 and Rac1-GTPase (its activated form). miR-142-3p antagomirs had opposite effects after oxygen-glucose deprivation/re-oxygenation. Our results indicate that miR-142-3p down-regulates the expression and activation of Rac1, regulates mitochondrial biogenesis and function, and inhibits oxygen-glucose deprivation damage, thus exerting a neuroprotective effect. The experiments were approved by the Committee of Experimental Animal Use and Care of Central South University, China (approval No. 201703346) on March 7, 2017.