Miracle-dz/UniFAR-FTUs huggingface dataset:
Fast and Robust Characterization of Lossy Dielectric Slabs Using Rectangular Waveguides

Waveguide characterization of dielectric materials is a convenient and broadband approach for measuring dielectric constant. In conventional microwave measurements, material samples are usually mechanically shaped to fit waveguide opening and measured in closed waveguides. This method is not practical for millimeter-wave and sub-millimeter-wave measurements where waveguide openings become tiny, and it is rather difficult to shape the sample to exactly the same dimensions as the waveguide cross section. In this article, we present a method that allows one to measure arbitrarily shaped dielectric slabs that extend outside waveguides. In this method, the measured sample is placed between two waveguide flanges, creating a discontinuity. The measurement system is characterized as an equivalent $\Pi $ -circuit, and the circuit elements of the $\Pi $ -circuit are extracted from the scattering parameters. We have found that the equivalent shunt impedance of the measured sample is only determined by the material permittivity and is rather insensitive to the sample shape, position, sizes, and other structural details of the discontinuity. This feature can be leveraged for accurate measurements of permittivity. We provide an analytical extraction formula for thin-layer dielectric samples. For thick layers, a numerical optimization method based on a feed-forward neural network is introduced to retrieve the permittivity. The proposed method is very useful for measuring the permittivity of medium-loss and high-loss dielectrics from microwave to sub-terahertz frequencies.
Effects of biomechanical forces on the biological behavior of cancer stem cells

Cancer stem cells (CSCs), dynamic subsets of cancer cells, are responsible for malignant progression. The unique properties of CSCs, including self-renewal, differentiation, and malignancy, closely depend on the tumor microenvironment. Mechanical components in the microenvironment, including matrix stiffness, fluid shear stress, compression and tension stress, affect the fate of CSCs and further influence the cancer process. This paper reviews recent studies of mechanical components and CSCs, and further discusses the intrinsic correlation among them. Regulatory mechanisms of mechanical microenvironment, which act on CSCs, have great potential for clinical application and provide different perspectives to drugs and treatment design.
Persistent brainstem abscess requiring repeat microsurgical drainage: case report

Abstract In this paper, we present a patient who was treated for a pontine abscess at our institution. This patient underwent sub-occipital craniotomy for microscopic abscess drainage after which cultures grew Streptococcus intermedius. She was treated with antibiotics but failed to show clinical improvement and was taken back to the operating room for repeat abscess drainage. Clinical improvement was seen after the second operation. This case report describes open surgical technique as a safe and effective way of treating brainstem abscess.
Social Investment Policies in the EU: Actively Concrete or Passively Abstract?

Against the historical‐conceptual background of EU social policy and evolutionary governance, this article analyses the approach with which the EU propagates social investment policies. Social investment, understood as an active rather than passive way of social protection, has become a salient instrument for reinvigorating the EU’s social dimension, especially in the aftermath of the sovereign debt crisis. By means of a large‐scale document analysis, we develop four EU social investment propagation approaches (reference, objective, tool, and action) according to how active (passive) and concrete (abstract) the EU’s intervention in social investment is. The results show that the EU mainly propagates social investment with an active approach, i.e., policy recommendations targeted at national governments. In terms of substance, the EU’s treatment of social investment is based on labour activation policies backed by skills development and job search support policies, which is consistent with the main purpose of social investment.
Computational Screening of Natural Compounds for the Discovery of Potential Aromatase Inhibitors: A Promising Therapy for Estrogen-Dependent Breast Cancer

Aromatase plays a significant role in the progression of estrogen receptor-positive (ER-positive) breast cancer. The adverse side effects of currently used aromatase inhibitors (AIs) necessitate the development of new AIs that are more active, selective, and less toxic. This study used a computational approach to screen 503 natural compounds ZINC database against the aromatase active site. The best scoring hits ZINC69482055, ZINC69482510, and ZINC406719 exhibited strong binding with aromatase, with binding energy values of -8.45, -10.35, and -8.75 kcal/mol, respectively, which is comparatively higher than that of the control compound Anastrozole (-6.43 kcal/mol). Docking analysis showed that the selected hits interacted with the crucial residues of the aromatase active site. This study suggested that these compounds could be used as possible AIs in the cure of breast cancer. Hands-on bench work validation is needed to optimize these compounds as AIs.
A comparative study of police organizational changes during the COVID-19 pandemic: responding to public health crisis or something else?

Abstract Police organizations—like many other social institutions—were forced to make changes in response to the COVID-19 pandemic. This exploratory study uses data from 28 countries to examine how the strength of the pandemic (e.g. infection rates and death rates) and governmental restrictions are related to these changes. The analyses of the data suggest the way in which police organizations responded to the pandemic was complicated. Infection rates are generally not as strongly related to changes as are death rates. Governmental restrictiveness is strongly related to some changes. Additional research is needed to tease out additional factors that potentially explain these changes as well as multivariate effects of these factors.
Appraisal System in GoGo Dino Theme Song Indonesian Translation Lyric

Movies or stories with superheroes theme always give color to the hearts of the audience. GoGo Dino animated series, which is an animated cartoon series from South Korea, also provides an excellent color to the audience. This study aims to analyze the Appraisal System used in the opening song lyrics of the Indonesian version of the GoGo Dino cartoon series. The research data obtained were then analyzed using Martin and White’s Appraisal System theory. Researchers used qualitative descriptive methods in explaining the results of the study. It can be seen that in the lyrics of the song, the author of the lyrics implements less use of affect and uses more judgment. The Judgment implementation shows that a person, or in this case, a superhero, is valued by his behavior parameters. From the behavior parameters, it can bring up the effect of affect which is a person’s reaction to the behavior.
Accelerated Atherosclerosis in Systemic Lupus Erythematosus: Role of Fibroblast Growth Factor 23- Phosphate Axis

Purpose Despite management advances, accelerated atherosclerotic cardiovascular disease (ACVD) remains a major cause of morbimortality in systemic lupus erythematosus (SLE) patients; that is not fully explained by traditional risk factors. Fibroblast growth factor-23 (FGF23) is a bone-derived phosphaturic hormone with multiple klotho-dependent and independent effects, including promotion of atherosclerosis and vascular calcification, particularly in the context of chronic kidney disease. Increased circulating FGF23 was reported in SLE patients, particularly with lupus nephritis (LN); but its atherogenic role in these disorders was not explored. Subjects and Methods Three study groups of predominantly middle-aged females were categorized by the 2012 SLE International Collaborating Clinics (SLICC) criteria as SLE (without LN), LN, or controls matching for traditional CVD risk profile. Measures of SLE activity, damage, steroid therapy, and glomerular filtration rate were calculated. Fasting blood samples were checked for serum lipid profile, anti-DNA, urea, creatinine, uric acid, proteins, albumin, calcium, phosphorus, C3, C4, CRP, vitamin-D3, intact parathyroid hormone and FGF23 (iFGF23). By carotid ultrasonography, mean common carotid artery intima-media thickness (CC-IMT), plaque score (PS) and internal carotid resistive index (ICRI) were recorded. Results CC-IMT, ICRI and serum iFGF23 differed along the study groups (LN>SLE>controls). In both SLE and LN patients, serum iFGF23 had a significant positive correlation with serum phosphorus, CC-IMT and PS. On multivariate analysis, the strongest predictor of increased CC-IMT was cumulative steroid dose in SLE and serum iFGF23 in LN patients. Most significant independent predictors of increased serum iFGF23 were hyperphosphatemia in SLE and proteinuria in LN patients. Conclusion FGF23-phosphate axis has a key role in accelerated ACVD in SLE patients. Serum phosphorus and iFGF23 should be included in ACVD risk profile assessment of these patients. Prospective studies shall define the role of dietary and/or pharmacologic control of hyperphosphatemia and proteinuria in reducing circulating iFGF23 and ACVD in them.
Chronic Quadriceps Tendon Rupture Reconstruction with Sartorius Muscle Transfer: A Report of Five Cases

Summary: Disruption of the knee extensor mechanism is an unfavorable situation because efficient mobilization requires a functioning knee extensor apparatus. The purpose of this retrospective study was to report our technique of sartorius muscle transfer for restoration of extension mechanism function and the outcomes of five patients. Patients with ruptured knee extensor mechanism secondary to trauma or knee arthroplasty-related issues were studied retrospectively. In all patients, sartorius muscle was transferred to restore the quadriceps tension deficit. Increase in the knee active range of motion, increase in the extensor mechanism power by one grade on Medical Research Council scale, and improvement in the extension lag were observed in all patients. The sartorius muscle transfer can be a reliable option to restore the knee extensor mechanism in chronic quadriceps tendon injuries. Our initial results are promising and showed improvement of the extensor mechanism muscle power, increased knee active range of motion, and decreased knee extension lag. The complications we observed did not impair the successful outcome of the sartorius transfer and were anticipated given the complexity of the studied cases. We encourage additional studies of sartorius muscle transfer to treat chronic quadriceps tendon injuries.
Identification of pollen taxa by different microscopy techniques

Melissopalynology is an important analytical method to identify botanical origin of honey. Pollen grain recognition is commonly performed by visual inspection by a trained person. An alternative method for visual inspection is automated pollen analysis based on the image analysis technique. Image analysis transfers visual information to mathematical descriptions. In this work, the suitability of three microscopic techniques for automatic analysis of pollen grains was studied. 2D and 3D morphological characteristics, textural and colour features, and extended depth of focus characteristics were used for the pollen discrimination. In this study, 7 botanical taxa and a total of 2482 pollen grains were evaluated. The highest correct classification rate of 93.05% was achieved using the phase contrast microscopy, followed by the dark field microscopy reaching 91.02%, and finally by the light field microscopy reaching 88.88%. The most significant discriminant characteristics were morphological (2D and 3D) and colour characteristics. Our results confirm the potential of using automatic pollen analysis to discriminate pollen taxa in honey. This work provides the basis for further research where the taxa dataset will be increased, and new descriptors will be studied.
Role of juvenile hormone receptor Methoprene-tolerant 1 in silkworm larval brain development and domestication

The insect brain is the central part of the neurosecretory system, which controls morphology, physiology, and behavior during the insect’s lifecycle. Lepidoptera are holometabolous insects, and their brains develop during the larval period and metamorphosis into the adult form. As the only fully domesticated insect, the Lepidoptera silkworm Bombyx mori experienced changes in larval brain morphology and certain behaviors during the domestication process. Hormonal regulation in insects is a key factor in multiple processes. However, how juvenile hormone (JH) signals regulate brain development in Lepidoptera species, especially in the larval stage, remains elusive. We recently identified the JH receptor Methoprene tolerant 1 (Met1) as a putative domestication gene. How artificial selection on Met1 impacts brain and behavioral domestication is another important issue addressing Darwin’s theory on domestication. Here, CRISPR/Cas9-mediated knockout of Bombyx Met1 caused developmental retardation in the brain, unlike precocious pupation of the cuticle. At the whole transcriptome level, the ecdysteroid (20-hydroxyecdysone, 20E) signaling and downstream pathways were overactivated in the mutant cuticle but not in the brain. Pathways related to cell proliferation and specialization processes, such as extracellular matrix (ECM)-receptor interaction and tyrosine metabolism pathways, were suppressed in the brain. Molecular evolutionary analysis and in vitro assay identified an amino acid replacement located in a novel motif under positive selection in B. mori, which decreased transcriptional binding activity. The B. mori MET1 protein showed a changed structure and dynamic features, as well as a weakened co-expression gene network, compared with B. mandarina. Based on comparative transcriptomic analyses, we proposed a pathway downstream of JH signaling (i.e., tyrosine metabolism pathway) that likely contributed to silkworm larval brain development and domestication and highlighted the importance of the biogenic amine system in larval evolution during silkworm domestication.
Raman scattering and X-ray diffraction studies on phase III of solid hydrogen

The structure of the phase III of solid hydrogen has been investigated from Raman scattering and X-ray powder diffraction experiments at low temperature based on the diamond anvil Raman gauge at pressures up to 300 GPa and 190 GPa, respectively. Observed splitting of low frequency Raman bands at around 230 GPa has suggested distinct lattice deformation of the hcp-like structure in phase III while X-ray diffraction data proposed that the molecular center was located in the vicinity of lattice points of hcp up to 190 GPa.
Amyloid pathology and synaptic loss in pathological aging

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive memory dysfunction and cognitive decline. Pathological aging (PA) describes patients who are amyloid‐positive but cognitively unimpaired at time of death. Both AD and PA contain amyloid plaques dominated by amyloid β (Aβ) peptides. In this study, we investigated and compared synaptic protein levels, amyloid plaque load, and Aβ peptide patterns between AD and PA. Two cohorts of post‐mortem brain tissue were investigated. In the first, consisting of controls, PA, AD, and familial AD (FAD) individuals, synaptic proteins extracted with tris(hydroxymethyl)aminomethane‐buffered saline (TBS) were analyzed. In the second, consisting of tissue from AD and PA patients from three different regions (occipital lobe, frontal lobe, and cerebellum), a two‐step extraction was performed. Five synaptic proteins were extracted using TBS, and from the remaining portion Aβ peptides were extracted using formic acid. Subsequently, immunoprecipitation with several antibodies targeting different proteins/peptides was performed for both fractions, which were subsequently analyzed by mass spectrometry. The levels of synaptic proteins were lower in AD (and FAD) compared with PA (and controls), confirming synaptic loss in AD patients. The amyloid plaque load was increased in AD compared with PA, and the relative amount of Aβ40 was higher in AD while for Aβ42 it was higher in PA. In AD loss of synaptic function was associated with increased plaque load and increased amounts of Aβ40 compared with PA cases, suggesting that synaptic function is preserved in PA cases even in the presence of Aβ.
Distribution of trespass cannabis cultivation and its risk to sensitive forest predators in California and Southern Oregon

Illegal cannabis cultivation on public lands has emerged as a major threat to wildlife in California and southern Oregon due to the rampant use of pesticides, habitat destruction, and water diversions associated with trespass grow sites. The spatial distribution of cultivation sites, and the factors influencing where they are placed, remain largely unknown due to covert siting practices and limited surveillance funding. We obtained cannabis grow-site locality data from law enforcement agencies and used them to model the potential distribution of cultivation sites in forested regions of California and southern Oregon using maximum entropy (MaxEnt) methods. We mapped the likely distribution of trespass cannabis cultivation sites and identified environmental variables influencing where growers establish their plots to better understand the cumulative impacts of trespass cannabis cultivation on wildlife. We overlaid the resulting grow-site risk maps with habitat distribution maps for three forest species of conservation concern: Pacific fisher (Pekania pennanti), Humboldt marten (Martes caurina humboldtensis), and northern spotted owl (Strix occidentalis caurina). Results indicate that cannabis cultivation is fairly predictably distributed on public lands in low to mid-elevation (~800-1600m) forests and on moderate slopes (~30–60%). Somewhat paradoxically, results also suggest that growers either preferred sites inside of recently disturbed vegetation (especially those burned 8–12 years prior to cultivation) or well outside (>500m) of recent disturbance, perhaps indicating avoidance of open edges. We ground-truthed the model by surveying randomly selected stream courses for cultivation site presence in subsets of the modeling region and found previously undiscovered sites mostly within areas with predicted high likelihood of grow-site occurrence. Moderate to high-likelihood areas of trespass cultivation overlapped with 40 to 48% of modeled habitats of the three sensitive species. For the endangered southern Sierra Nevada fisher population, moderate-high likelihood growing areas overlapped with over 37% of modeled fisher denning habitat and with 100% of annual female fisher home ranges (mean overlap = 48.0% + 27.0 SD; n = 134) in two intensively studied populations on the Sierra National Forest. Locating and reclaiming contaminated cannabis grow sites by removing all environmental contaminants should be a high priority for resource managers.
Convergent geographic patterns between grizzly bear population genetic structure and Indigenous language groups in coastal British Columbia, Canada

Landscape genetic analyses of wildlife populations can exclude variation in a broad suite of potential spatiotemporal correlates, including consideration of how such variation might have similarly influenced people over time. Grizzly bear (Ursus arctos) populations in what is now known as coastal British Columbia, Canada, provide an opportunity to examine the possible effects of a complex set of landscape and human influences on genetic structure. In this collaboration among the Nuxalk, Haíɫzaqv, Kitasoo/ Xai’xais, Gitga’at, and Wuikinuxv First Nations and conservation scientists, we characterized patterns of genetic differentiation in the grizzly bear, a species of high cultural value, by genotyping 22 microsatellite loci from noninvasively collected hair samples over a 23,500 km2 area. We identified three well-differentiated groups. Resistance surfaces, which incorporated past and present human use, settlement, and landscape resistant features, could not explain this pattern of genetic variation. Notably, however, we detected spatial alignment between Indigenous language families and grizzly bear genetic groups. Grizzly bears sampled within an area represented by a given language family were significantly similar to those sampled within that language family (P = 0.001) and significantly divergent to those sampled outside the language family (P = 0.001). This spatial co-occurrence suggests that grizzly bear and human groups have been shaped by the landscape in similar ways, creating a convergence of grizzly bear genetic and human linguistic diversity. Additionally, grizzly bear management units designated by the provincial government currently divide an otherwise continuous group and exclude recently colonized island populations that are genetically continuous with adjacent mainland groups. This work provides not only insight into how ecological and geographic conditions can similarly shape the distribution of people and wildlife but also new genetic evidence to support renewed, locally led management of grizzly bears into the future.
Big Data Characteristics (V’s) in Industry

In the new digital age, Data is the collection of the observation and facts in terms of events, thus data is continuously growing, getting denser and more varied by the minute across multiple channels. Nowadays, consumers generate mass amounts of data on a daily basis. Hence, Big Data (BD) emerged and is evolving rapidly, the various types of data being processed are huge, and ensuring that this data is being used efficiently is becoming increasingly more difficult. BD has been differentiated into several characteristics (the V’s) and many researchers have been developing more characteristics for new purposes over the past years. Therefore, it is shown from observation that there is a clear gap between researchers about the current status of the BD characteristics. Even after the introduction of newer characteristics, many papers are still proposing the use of 3 or 5 V’s, while some researchers are far more progressed and has reached up to 10V’s. This paper will provide an overview of the main characteristics that have been added over time and investigate the recent growth of Big Data Analytics (BDA) characteristics in each industry sector which will provide some detailed and general scope for most researchers to consider and learn from.
Rapid Detection of Carbapenemase-producing Enterobacteriaceae From Blood Culture Bottles of Known CPE Carriers

We used a rapid antigen test for the detection of carbapenemases directly from positive blood culture bottles of pediatric hemato-oncologic patients, known carriers of carbapenemase-producing enterobacteriaceae. Resistance mechanism was detected within 15 minutes of observing Gram-negative bacilli from a positive bottle, leading to treatment modification. This simple-to-use, inexpensive assay shortens the interval between empiric to tailored antimicrobial therapy.