Miracle-dz/UniFAR-FTUs huggingface dataset:
Real-time jam-session support system

We propose a method for the problem of real time chord accompaniment of improvised music. Our implementation can learn an underlying structure of the musical performance and predict next chord. The system uses Hidden Markov Model to find the most probable chord sequence for the played melody and then a Variable Order Markov Model is used to a) learn the structure (if any) and b) predict next chord. We implemented our system in Java and MAX/Msp and compared and evaluated using objective (prediction accuracy) and subjective (questionnaire) evaluation methods.
Use of a new model allowing controlled uniaxial loading to evaluate tendon healing in a bone tunnel

The optimal mechanical loading regimen for the healing of a tendon graft in a bone tunnel is unknown. We developed a rat model that directly tensions a healing tendon graft, without the use of confounding joint motion. Fifty cycles of either 0, 3, or 6 N of tension were applied to groups daily for 3 or 6 weeks. At 3 weeks the low load (3 N) group had the highest failure load (p = 0.009), but by 6 weeks there were no differences in failure load among groups. At 3 weeks the high load (6 N) group had greater osteoclast activity compared to the immobilized (0 N) group (p < 0.05), and by 6 weeks there were significantly more osteoclasts in the high load group compared to the low load group (p = 0.01). Bone volume fraction was higher in the immobilized group compared to the 3 N load group at 3 weeks (p = 0.014) and 6 weeks (p = 0.007). At 6 weeks, the immobilized group had greater trabecular number compared to both loading groups (p < 0.05). In conclusion, low magnitude loading had a beneficial early effect but continued loading led to poorer new bone formation over time and no beneficial effect at 6 weeks, perhaps due to delayed maturation from cumulative loads. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:852–859, 2016.
Field N 2 O , CO 2 and CH 4 ̄ uxes in relation to tillage , compaction and soil quality in Scotland

Tillage practices and weather affect the release of greenhouse gases but there have been few integrated studies of the quantities released or the mechanisms involved. No-tillage may increase emissions of nitrous oxide (N2O) and the ®xation of carbon by decreasing carbon dioxide (CO2) emissions. Tillage may also decrease the oxidation rate of atmospheric methane (CH4) in aerobic soil. These effects are partly due to compaction and to the lack of both soil disturbance and residue incorporation. Our objective was to investigate how tillage practices, soil conditions and weather interact to in ̄uence greenhouse gas emissions. Here we present early measurements of N2O and CO2 emission and CH4 oxidation in two ®eld experiments in Scotland under a cool moist climate, one involving soil compaction plus residue incorporation and the other involving no-tillage and two depths of mouldboard ploughing of a former grass sward. The experiments were located 10± 15 km south of Edinburgh on a cambisol and a gleysol. In order to monitor emissions regularly, at short intervals and over long periods, a novel automatic gas sampling system which allows subsequent automated determination of both N2O and CO2 ̄uxes was used. Both N2O and CO2 ̄uxes were episodic and strongly dependent on rainfall. Peak N2O emissions were mainly associated with heavy rainfalls after fertilisation, particularly with no-tilled and compact soils. In the tillage experiment, N2O ̄uxes and treatment differences were greater under spring barley (Hordeum vulgare L.) (up to 600 g N haÿ1 per day) than under winter barley. CO2 emissions in the few weeks after sowing were not strongly in ̄uenced by tillage and diurnal variations were related to soil temperature. However, periods of low or zero CO2 ̄uxes and very high N2O ̄uxes under notillage were associated with reduced gas diffusivity and air-®lled porosity, both caused by heavy rainfall. Early results show that CH4 oxidation rates may best be preserved by no-tillage. The quality of the loam/clay-loams and the climate in these experiments makes ploughing, preferably to 300 mm depth, and the control of compaction necessary to minimise soil N2O and CO2 losses. The gas exchange response of different soil types to tillage, particularly methane oxidation rate which is affected by long-term soil structural damage, is a potentially useful aspect of soil quality when taken in conjunction with other qualities. # 1999 Elsevier Science B.V. All rights reserved.
What features of educational interventions lead to competence in aseptic insertion and maintenance of CV catheters in acute care? BEME Guide No. 15

Background: Up to 6000 patients per year in England acquire a central venous catheter (CVC)-related bloodstream infection (Shapey et al. ). Implementation of Department of Health guidelines through educational interventions has resulted in significant and sustained reductions in CVC-related blood stream infections (Pronovost et al. 2002), and cost (Hu et al. ). Aim: This review aimed to determine the features of structured educational interventions that impact on competence in aseptic insertion technique and maintenance of CV catheters by healthcare workers. Methods: We looked at changes in infection control behaviour of healthcare workers, and considered changes in service delivery and the clinical welfare of patients involved, provided they were related directly to the delivery method of the educational intervention. Results: A total of 9968 articles were reviewed, of which 47 articles met the inclusion criteria. Conclusions: Findings suggest implications for practice: First, educational interventions appear to have the most prolonged and profound effect when used in conjunction with audit, feedback, and availability of new clinical supplies consistent with the content of the education provided. Second, educational interventions will have a greater impact if baseline compliance to best practice is low. Third, repeated sessions, fed into daily practice, using practical participation appear to have a small, additional effect on practice change when compared to education alone. Active involvement from healthcare staff, in conjunction with the provision of formal responsibilities and motivation for change, may change healthcare worker practice.
What's in a rehab? Ethnographic evaluation research in Indigenous Australian residential alcohol and drug rehabilitation centres

Residential rehabilitation centres are a popular form of treatment for Indigenous Australians suffering from alcohol and drug misuse; however, there has been very little substantive research and evaluation in this area. Based on long-term ethnographic research, this study examines the informal aspects of a treatment programme in an Indigenous residential alcohol and drug rehabilitation service. Evaluation of such services often focuses on treatment length and/or treatment level obtained as key indicators of success. This study suggests that ‘treatment’ may be more complex and layered with multiple levels of meaning, which may not necessarily be captured in some evaluation designs. For the residential rehabilitation centre discussed in this paper, oscillating periods of mutual support and discipline have an important therapeutic function. Standard measures of treatment length and level obtained are meaningless without incorporating understanding of this process. This paper presents some of the ethnographic findings, alongside some of the evaluation implications of doing this kind of research.
Migration Patterns and the Growth of High‐Poverty Neighborhoods, 1970‐‐19901

Using geocoded data from the Panel Study of Income Dynamics, this article examines why the number of high‐poverty neighborhoods in American cities has increased since 1970. The main findings are (1) the migration of the nonpoor away from moderately poor neighborhoods has been a key process in forming new high‐poverty neighborhoods, although in the early 1980s increasing poverty rates were also important; and (2) African‐Americans have moved into predominately white neighborhoods at a pace sufficient to increase their numbers there, but neighborhoods with increasing black populations tend to lose white population rapidly. Implications for theories of poor neighborhoods are discussed.
Efficient Characterization of Threshold Voltage Instabilities in SiC nMOSFETs Using the Concept of Capture-Emission-Time Maps

We utilize the recently suggested capture-emission-time (CET) maps for the first time for SiC technologies. CET maps are a very powerful characterization technique which allow the elegant and comprehensive analysis of oxide/interface traps at or near the semiconductor-dielectric interface and were originally developed to characterize degradation of Si based MOSFETs. For as-processed SiC MOSFETs we present first results of the SiC-SiO2 interface using CET maps. We suggest that oxide traps are mainly responsible for the instability in SiC MOSFETs. Furthermore we state that the large time constants and the temperature activation of the traps in SiC MOSFETs can be consistently explained when accounting for multi-phonon processes for the microscopic charge exchange. A recently suggested model including such microscopic transitions is applied to SiC MOSFETs and shown to reproduce our experimental data with high accuracy for a large temperature range.
Urokinase Plasminogen Activator and Urokinase Plasminogen Activator Receptor Mediate Human Stem Cell Tropism to Malignant Solid Tumors

Human neural and mesenchymal stem cells have been identified for cell‐based therapies in regenerative medicine and as vehicles for delivering therapeutic agents to areas of injury and tumors. However, the signals required for homing and recruitment of stem cells to these sites are not well understood. Urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR) are involved in chemotaxis and cell guidance during normal development and are upregulated in invasive tumors. Here we provided evidence that activation of uPA and uPAR in malignant solid tumors (brain, lung, prostate, and breast) augments neural and mesenchymal stem cell tropism. Expression levels of uPAR on human solid tumor cell lines correlated with levels of uPA and soluble uPAR in tumor cell‐conditioned media. Cytokine expression profiles of these tumor‐conditioned media were determined by protein arrays. Among 79 cytokines investigated, interleukin (IL)‐6, IL‐8, and monocyte chemoattractant protein‐1 were the most highly expressed cytokines in uPAR‐positive tumors. We provided evidence that human recombinant uPA induced stem cell migration, whereas depletion of uPA from PC‐3 prostate cancer cell‐conditioned medium blocked stem cell migration. Furthermore, retrovirus‐mediated overexpression of uPA and uPAR in neuroblastoma (NB1691) cells induced robust migration of stem cells toward NB1691 cell‐conditioned media, compared with media derived from wild‐type NB1691 cells. We conclude that expression of uPA and uPAR in cancer cells underlies a novel mechanism of stem cell tropism to malignant solid tumors, which may be important for development of optimal stem cell‐based therapies.
Cooperative Output Regulation of Heterogeneous Unknown Systems via Passification-Based Adaptation

While several robust cooperative output regulation approaches for heterogeneous systems have been proposed (with fixed-gain distributed controllers), the design of adaptive-gain distributed controllers becomes relevant in dealing with larger uncertainty than robust approaches. This letter addresses the adaptive cooperative output regulation problem for heterogeneous systems with unknown linear dynamics, where possibly large system uncertainty would make fixed-gain robust approaches not applicable. A passification method is adopted to design adaptive-gain distributed controllers solving the problem. The proposed method includes two steps: in the first step, a distributed observer of the exogenous signal is designed for those systems that cannot access the exosystem, and a reference model is designed whose output can converge to the exogenous signal; in the second step, command generator tracking is achieved via adaptive laws that make the output of each system converge to the output of the reference model, and thus to the exogenous signal. Stability analysis is provided via a Lyapunov approach, and a numerical example illustrates the effectiveness of the approach.
Exercise Programs for Children: A Way to Prevent Heart Disease?

In brief Physical activity patterns of 59 children were determined by recording heart rates before and during an exercise intervention program for coronary heart disease risk. Twenty-six children engaged in 25-minute aerobic activity sessions four days a week for eight months; the control group took regular physical education classes. Baseline data revealed that both groups had similar activity patterns, that the children seldom attained a heart rate greater than 160 beats min-1, and that the boys expended significantly more energy per day than the girls. The activity patterns of children in the experimental group improved significantly.
Architecting safety-critical decision-support systems for nuclear emergency management

Abstract We present the architecture of the new ABR-KFUE decision-support system for nuclear emergency management used in Germany. Such systems assist decision makers in taking countermeasures in case of releases of radioactive materials into the environment. The specificity of these systems is that they use simulation software in a safety-critical application context. The new architecture of the system thus aims at fulfilling non-functional requirements for improved reliability, performance, availability, and maintainability. The proposed solutions are evaluated using a stimulus/response analysis.
Direction-Specific Disruption of Subcortical Visual Behavior and Receptive Fields in Mice Lacking the β2 Subunit of Nicotinic Acetylcholine Receptor

Retinotopic mapping is a basic feature of visual system organization, but its role in processing visual information is unknown. Mutant mice lacking the β2 subunit of nicotinic acetylcholine receptor have imprecise maps in both visual cortex (V1) and the superior colliculus (SC) due to the disruption of spontaneous retinal activity during development. Here, we use behavioral and physiological approaches to study their visual functions. We find that β2−/− mice fail to track visual stimuli moving along the nasotemporal axis in a subcortical optomotor behavior, but track normally along the dorsoventral axis. In contrast, these mice display normal acuity along both axes in the visual water task, a behavioral test of cortical functions. Consistent with the behavioral results, we find that V1 neurons in β2−/− mice have normal response properties, while SC neurons have disrupted receptive fields, including enlarged structure and decreased direction and orientation selectivity along the nasotemporal axis. The subcortical-specific deficits indicate that retinotopic map disruption has different impacts on the development of functional properties in V1 and the SC.
Taxometric Analyses of Pedophilia Utilizing Self-Report, Behavioral, and Sexual Arousal Indicators

Pedophilia refers to the recurrent, intense sexual interest in prepubescent children who, by definition, have not developed any secondary sex characteristics. Researchers have begun to investigate whether persons with pedophilia are qualitatively different from those without pedophilia (pedophilia is a taxon) or if people vary in their level of sexual interest toward children (pedophilia is dimensional). Two relatively small studies have previously attempted to address this question, but produced conflicting results. The present study built on these studies with a substantially larger sample of 2,227 men who committed sexual offenses and were assessed at a sexual behavior clinic. The present study also examined a broader range of measures more closely approximating the diagnostic criteria for pedophilic disorder, including phallometric assessment of sexual arousal patterns. The results of 3 taxometric analyses did not find support for the assertion that pedophilia is a taxon.
Genetic Variations in Metallothionein Genes and Susceptibility to Hypertensive Disorders of Pregnancy: A Case-Control Study

Background: The involvement of oxidative stress in the pathological process of hypertensive disorders of pregnancy (HDP) gives rise to the interest in exploring the association of genetic variations in antioxidant metallothionein (MT) genes with HDP susceptibility. Methods: Seventeen single-nucleotide polymorphisms(SNPs) in MT genes were selected to conduct genotyping based on a case-control study consisting of 371 HDP cases (pregnancy with chronic hypertension (66), gestational hypertension (172), and preeclampsia or preeclampsia superimposed on chronic hypertension (133)) and 479 controls. The association between SNPs in MTs and the risk of HDP was estimated with unconditional logistic regression analysis and further tested with the false-positive report probability (FPRP) procedure. The joint effects of SNPs on the HDP risk were assessed by haplotype analysis. Results: After the adjustment for age and pre-pregnancy body mass index (pre-BMI) in the logistic regress analysis and followed by the FPRP test, the genetic variation rs10636 (OR = 0.46, 95% CI: 0.30–0.71 for GG vs. CC, p = 0.000 and OR = 0.48, 95% CI: 0.32–0.73 for GG vs. CG/CC, p = 0.001) in MT2A was associated with gestational hypertension. Other four SNPs, that is, rs11076161 (OR = 1.89, 95% CI: 1.35–2.63 for GG vs. GA/AA, p = 0.000) in MT1A; rs7191779 (OR = 1.54, 95% CI: 1.11–2.13 for CC vs. CG/GG, p = 0.010) in MT1B; rs8044719 (OR = 0.57, 95% CI: 0.40–0.80 for GT vs. GG, p = 0.001) in MT1DP; and rs8052334 (OR = 1.52, 95% CI: 1.10–2.11 for TT vs. TC/CC, p = 0.012) in MT1B were significantly associated with the susceptibility of HDP. The haplotype analysis among 11, 10, 10, and seven SNPs in MT (MT1A, MT2A, MT1M, MT1B, and MT1DP) genes showed that eight (A-C-G-T-C-G-A-G-C-G-C, OR = 4.559; A-C-T-C-C-C-A-G-C-G-C, OR = 5.777; A-C-T-T-C-G-A-G-C-G-C, OR = 4.590; G-A-T-C-C-G-C-G-G-C-C, OR = 4.065; G-A-T-C-G-C-C-G-G-C-C, OR = 4.652; G-A-T-T-C-C-C-G-G-C-C, OR = 0.404; G-C-T-C-C-C-A-G-G-C-C, OR = 1.901; G-C-T-T-C-C-A-G-G-C-C, and OR = 3.810), five (C-G-A-T-C-A-C-C-G-G, OR = 2.032; C-G-A-T-C-G-C-C-G-G, OR = 2.077; G-A-C-T-C-A-C-C-T-G, OR = 0.564; G-G-A-G-C-A-C-C-G-G, OR = 5.466; G-G-A-T-T-A-G-C-G-G, and OR = 0.284), five (A-C-G-T-C-G-A-G-C-C, OR = 2.399; A-C-T-C-C-C-C-T-G-G, OR = 0.259; G-A-T-C-C-C-C-G-G-C, OR = 1.572; G-A-T-C-G-C-C-G-G-C, OR = 0.001; G-C-T-C-G-C-A-G-G-C, and OR = 2.512), and five (A-C-T-C-C-C-G, OR = 0.634; G-A-G-C-C-C-G, OR = 4.047; G-A-T-T-G-C-G, OR = 0.499; G-C-G-T-C-A-G, and OR = 7.299; G-C-T-C-C-A-G, OR = 1.434) haplotypes were significantly associated with pregnancy with chronic hypertension, gestational hypertension, preeclampsia, or preeclampsia superimposed on chronic hypertension and HDP. Conclusion: These variant MT alleles and their combination patterns may be used as genetic markers for predicting HDP susceptibility.
Lactate Kinetics and Individual Anaerobic Threshold*

Exercise with stepwise increasing work loads until exhaustion leads to a curvilinear increase of lactate in blood and typical lactate kinetics in the post-exercise period. Lactate kinetics in blood during exercise and recovery results from diffusion along gradients between muscle and blood and simultaneous elimination. Therefore, a general diffusion-elimination model is presented from which maximal rate of elimination (Em), individual anaerobic threshold (IAT), gradient between muscle and blood (deltaC-deltaCEm), muscle volume working above the IAT (Vm), individual membrane constant (Mc), quantity of lactate accounting for lactate gradient (Agrad), and whole body lactate (Anet) can be obtained. For demonstration purpose, this model was applied to a highly trained athlete. In this example, all constants and variables mentioned above as well as an equation reflecting individual lactate kinetics were calculated. Furthermore, the IAT was determined in 61 athletes participating in different events. In general, it can be demonstrated that with increasing aerobic capacity the lactate concentration at the IAT decreases. The lactate concentration at the IAT varies interindividually within broad limits, thus emphasizing the need for individual assessment.
Zinc Oxide Nanoparticle Improves the Intestinal Function of Intrauterine Growth Retardation Finishing Pigs via Regulating Intestinal Morphology, Inflammation, Antioxidant Status and Autophagy

This study was to investigate effects of zinc oxide nanoparticle (Nano-ZnO) on growth, immunity, intestinal morphology and function of intrauterine growth retardation (IUGR) finishing pigs. Six normal birth weight (NBW) and 12 IUGR male piglets were obtained and weaned at 21 d. NBW-weaned piglets fed basal diets (NBW group), IUGR-weaned piglets allocated to two groups fed basal diets (IUGR group) and basal diets further supplemented 600 mg Zn/kg from Nano-ZnO (IUGR+Zn group), respectively. All pigs were slaughtered at 163 d. Results showed: (1) IUGR pigs showed no difference in body weight at 77d and 163d (P > 0.05), while had increased villus height (VH) and villus surface area in jejunum (P < 0.05) and enhanced interleukin-6, TNF-α and NF-κB mRNA expression (P < 0.05) as compared to NBW group; Compared with IUGR group, dietary Nano-ZnO did not affect the body weight (P > 0.05), but increased VH to crypt depth ratio and IgA concentration (P < 0.05) and decreased TNF-α and NF-κB mRNA expression in jejunum (P < 0.05). (2) IUGR increased the number of swollen mitochondria and autolysosomes, and protein expressions of sequestosome-1 (P62) and microtubule-associated protein light chain 3 B/A (LC3B/A) in jejunum as compared to NBW group (P < 0.05); Compared with IUGR group, Nano-ZnO decreased the number of swollen mitochondria and autolysosomes, and P62 and LC3B/A protein expression (P < 0.05). (3) IUGR increased mucosal contents of malondialdehyde and protein carbonyl (PC) and Keap1 protein expression (P < 0.05) as compared to NBW group; Compared with IUGR group, dietary Nano-ZnO increased activities of total antioxidant capacity, catalase, glutathione peroxidase, and glutathione content (P < 0.05), and enhanced nuclear respiratory factor 2 (Nrf2), glutamate-cysteine ligase modifier subunit and glutathione peroxidase 1 mRNA expression, and increased total and nuclear Nrf2 protein expression (P < 0.05), and decreased malondialdehyde and PC content, and Keap1 protein expression (P < 0.05) in jejunum. Results suggested that IUGR pigs showed postnatal catch-up growth and improved intestinal morphology, and dietary Nano-ZnO may further improve intestinal morphology, reduce inflammation, decrease autophagy and alleviate oxidative stress via Nrf2/Keap1 pathway in jejunum of IUGR pigs.