Miracle-dz/UniFAR-FTUs huggingface dataset:
Phase II Study of Sunitinib in Patients with Non-small Cell Lung Cancer and Irradiated Brain Metastases

Introduction: Brain metastases frequently cause significant morbidity in patients with non-small cell lung cancer (NSCLC). Sunitinib is a multitargeted inhibitor of tyrosine kinase receptors, including vascular endothelial growth factor receptors and platelet-derived growth factor receptors, which has single-agent antitumor activity in refractory NSCLC. This phase II study evaluated the antitumor activity and safety of sunitinib in patients with pretreated NSCLC and irradiated brain metastases. Methods: Patients received sunitinib 37.5 mg on a continuous daily dosing schedule. The primary end point was progression-free survival. Secondary end points included overall survival, patient-reported outcomes, and safety, including risk of intracranial hemorrhage (ICH) associated with focal neurological deficit. Results: Sixty-four patients received sunitinib (median age 61 years), most (83%) had received prior systemic therapy, 63% had adenocarcinoma, and 19% had squamous cell carcinoma; most (55%) were never-smokers. Median progression-free survival was 9.4 weeks (90% confidence interval [CI]: 7.5–13.1), and median overall survival was 25.1 weeks (95% CI: 13.4–35.5). The most common treatment-emergent (all-causality) nonhematologic toxicities (any grade) were fatigue (38%) and decreased appetite and constipation (both 25%). The most common grade 3/4 nonhematologic toxicities were dyspnea (9%) and fatigue (8%). Lymphopenia (20%) and neutropenia (13%) were the most common grade 3/4 hematologic abnormalities. Serious neurologic adverse events occurred in six patients (9%), and none were treatment-related. No cases of ICH were reported. Conclusions: Sunitinib administration on a continuous daily dosing schedule in patients with NSCLC and brain metastases was safe and manageable, with no increased risk of ICH.
Mothers of babies requiring special care: Attitudes and experiences

Abstract The birth and admission of an infant for specialized neonatal care is a time of stress and upheaval for parents. Data were collected on the experience of 420 families whose babies had been admitted to one of 23 neonatal units in England. Mothers perceptions of their baby and the care provided are described and their relationship with other factors, including parity, the severity of illness, gestational age and duration of stay examined. In the short term having a small, immature, often sick infant appears to affect mothers' attitudes and perceptions of their ability to parent such an infant. However, in the longer term, as the infant progresses and develops, these effects appear to be diminished, though for mothers whose babies were very premature and small there appeared to be longer lasting effects.
Dementia case registers

The increase in the numbers of those aged over 65, in most populations, during recent decades, has greatly increased demands on the mental health services. This is especially true in the context of the dementias. These conditions, for the most part chronic and irreversible, have been estimated to affect 5% of the population over 65 and 20% of those in their eighties (Henderson, 1986). An evaluation of nearly fifty studies suggested that the prevalence of dementia increased exponentially with age, doubling about every five years at least until the age of 85 (Jorm et al., 1987). Some have talked of a dementia ‘epidemic’ (Br. Med. J., 1978). This situation poses many challenges ranging from the elucidation of aetiology to a need to determine optimal service provision. Such areas of interest possess a common requirement: the need for high quality data. One way of obtaining such data is the psychiatric case register. Case registers have traditionaly functioned as information systems that record the contacts of patients, from a defined geographical area, with medical and social services (Wing, 1989). Alternatively individuals with, or at risk of, a disease can be assessed and followed up whether or not they have health service contacts. The file collected on each individual is cumulative so that his or her care and progress (and, therefore, that of a similarly diagnosed group) can be followed over time. Such information provides a natural history of specific disorders. It therefore facilitates epidemiological and aetiological research and is essential for the planning, operation and evaluation of health care services (Larson et al., 1990). Psychiatric case registers have been established in many parts of the world in recent years (Ten Horn, 1989). Their work has been greatly extended by the increasing use of computers to process data (see, for example, Levy, 1990). Here we wish specifically to consider dementia case registers: their potential, problems, recent developments and prospects. The field is large and our review has had to be selective, emphasising some issues at the expense of others.
Analysis of Phylogenetic Relationships of Main Citrus Germplasms Based on Ftir Spectra of Petals

To develop a quick, accurate and reliable technique for studying phylogenetic relationship of Citrus, FTIR (Fourier transform infrared spectroscopy) technique was used. The petals spectra of eighteen varieties of citrus germplasms were investigated by FTIR. Pretreatment methods of raw spectra (2000–500 cm − 1) were composed of baseline correction, normalize and first derivative (Savitzky-Golay). We used One-way ANOVA (analysis of variance) and Tukey’s HSD (honestly significant difference) to extract effective wave bands, where the spectral absorbance values of different citrus germplasms were significantly different. The results showed that 2000∼1831 cm − 1, 1763∼1595 cm − 1, 1517∼1090 cm − 1, 1035∼1024 cm − 1, 950∼935 cm − 1, 861∼784 cm − 1, 744∼721 cm − 1 and 653∼608 cm − 1 were the effective wave bands. HCA (hierarchical cluster analysis) was adopted to classify citrus germplasms based on the above eight effective wave bands. It was found that eighteen citrus varieties were classified into six subgroup.
Clinicopathological Characteristics of 11 NSCLC Patients with EGFR-Exon 20 Mutations

Introduction: The characteristics of different types of epidermal growth factor receptor (EGFR) gene mutations in non–small-cell lung cancer (NSCLC) are not extensively studied. The distribution of EGFR mutations is known, with the most frequent in exon 19 (deletions) or exon 21 (point mutations). Aberrations in exon 18 or 20 are infrequently found. Point mutations in exon 20 confer resistance against tyrosine kinase inhibitors (TKIs), whereas the effect of the rare exon 20 insertions is, to a lesser extent, known. We present clinicopathological characteristics of patients with EGFR mutations in the four exons, with emphasis on exon 20 positive patients. Methods: NSCLC patients who tested positively for EGFR mutations at the Oslo University Hospital, Oslo, Norway in the period between May 2010 and February 2012 were selected. Clinical information was collected for mutated patients, and response information for patients with exon 20 insertions treated with TKI is reported. Results: Of 119 patients with EGFR mutation, 62.2% were women. The median age was 66.0 years. The frequency of exon 18, 19, 20, and 21 was 7%, 45%, 7%, and 38%, respectively. Four patients (3.3%) had double mutations, and exon 20 was involved in three of these. Seven of 11 exon 20 positive patients were treated with TKI. All five single-mutated exon 20 positive TKI-treated patients had progressive disease at first evaluation, whereas both TKI-treated exon 20 involving double-mutated patients had partial response. Conclusion: Exon 20 mutations seem to confer insensitivity to TKI treatment.
Rates of Alcohol/Other Drug Treatment Denials to Persons With Physical Disabilities: Accessibility Concerns

A growing body of research has developed indicating that substance abuse treatment facilities have numerous physical and programmatic barriers that could inhibit the ability of persons with disabilities (PWDs) to access care. Research has found that physical barriers do, in fact, result in service denials for individuals with spinal cord injury (SCI) and traumatic brain injury (TBI). The current research was undertaken to validate these findings with regard to persons with SCI and TBI, as well as to examine the impact of such barriers on the ability of individuals with other physical disabilities, including multiple sclerosis (MS), muscular dystrophy (MD), and other significant mobility impairments. Findings indicate that PWDs from each of these groups are denied services due to the presence of physical barriers at notable rates. Denial rates ranged from 65% for those with other significant mobility impairments to 87% for individuals with MS. Such extreme rates of services declines indicate a need for immediate action to address the accessibility of substance abuse treatment centers.
A method of virtual machine placement for fault-tolerant cloud applications

AbstractCloud applications are usually large scale and complicated. The placement of virtual machines (VMs) for highly reliable cloud applications is a challenging and critical research problem. To attack this challenge, a method of VM placement based on adaptive selection of fault-tolerant strategy for cloud applications is proposed. It involves two phase. In the first phase, the fault-tolerant strategies of cloud applications are sorted according to the constantly change of cloud applications constraint factors including the response time, failure rate and resource consumption. In the second phase, the VM placement plan based on adaptive selection of fault-tolerant strategy for cloud applications is solved. A prototype of VM placement framework based on adaptive selection of fault-tolerant strategy for cloud applications, named SelfAdaptionFTPlace, is implemented. Experimental results demonstrate that the proposed method shows up better performance and VM placement plan according to the constant change .
Immune therapies for lung cancer.

S394 Copyright © 2012 by the International Association for the Study of Lung Cancer Up until recently, attempts at immune modulation in lung cancer have failed to demonstrate a consistent impact on survival. Several promising novel strategies are currently being evaluated in clinical trials, with early evidence of activity. Two approaches of particular interest have been vaccines and immune checkpoint inhibition.The former enables enhanced exposure to tumor antigen whereas the latter aims to counteract physiologic mechanisms of immune tolerance coopted by some tumors. Below is a summary of specific immunotherapies presented during the 12th Targeted Therapies for Lung Cancer Meeting.
How Long Should Small Lung Lesions of Ground-Glass Opacity be Followed?

Introduction: Pulmonary ground-glass nodules are frequently encountered. The purpose of this study was to evaluate the natural history of them and to gain some insights on how to follow them up. Methods: We retrospectively studied patients with pulmonary nodules that met the following criteria: (1) tumor diameter of 3 cm or less, (2) ground-glass opacity proportion of 50% or more, and (3) observation without treatment for 6 months or more. Between 1999 and 2012, 108 pulmonary lesions in 61 patients fulfilled these criteria. We reevaluated their computed tomography images and analyzed changes in their size. Results: The tumors were 1 cm or lesser in size in 69 lesions, 1.1 cm to 2 cm in 34, and 2.1 cm to 3 cm in five. The proportion of solid lesions was 0% for 82 lesions, 1% to 25% for 19, and 26% to 50 % for seven. At the median observation period of 4.2 years, 29 lesions had become larger, whereas the remaining 79 had persisted without changing in size (±1 mm). The median size change in the nodules that grew was 7 mm (range, 2–32 mm). All 29 tumors began to grow within 3 years of their first observation: 1 year or lesser in 13 lesions, after 1.1 years to 2 years in 12, and after 2.1 years to 3 years in four. Conclusions: Some small lung lesions exhibiting ground-glass opacity persisted without changes in size, whereas others grew gradually. The tendency to grow was clear within the first 3 years in all cases. Therefore, we conclude that these lesions should be followed for at least 3 years.
Phase 2 Study of Pemetrexed Plus Carboplatin, or Pemetrexed Plus Cisplatin with Concurrent Radiation Therapy Followed by Pemetrexed Consolidation in Patients with Favorable-Prognosis Inoperable Stage IIIA/B Non–Small-Cell Lung Cancer

Introduction: There is no consensus chemotherapy regimen with concurrent radiotherapy (RT) for inoperable stage IIIA/B non–small-cell lung cancer. This trial evaluated pemetrexed with carboplatin (PCb) or cisplatin (PC) with concurrent RT followed by consolidation pemetrexed. Methods: In this open-label, noncomparative phase II trial, patients with inoperable stage IIIA/B non–small-cell lung cancer (initially all histologies, later restricted to nonsquamous) were randomized (1:1) to PCb or PC with concurrent RT (64–68 Gy over days 1–45). Consolidation pemetrexed monotherapy was administered every 21 days for three cycles. Primary endpoint was 2-year overall survival (OS) rate. Results: From June 2007 to November 2009, 98 patients were enrolled (PCb: 46; PC: 52). The 2-year OS rate was PCb: 45.4% (95% confidence interval [CI], 29.5–60.0%); PC: 58.4% (95% CI, 42.6–71.3%), and in nonsquamous patients was PCb: 48.0% (95% CI, 29.0–64.8%); PC: 55.8% (95% CI, 38.0–70.3%). Median time to disease progression was PCb: 8.8 months (95% CI, 6.0–12.6 months); PC: 13.1 months (95% CI, 8.3–not evaluable [NE]). Median OS (months) was PCb: 18.7 (95% CI, 12.9–NE); PC: 27.0 (95% CI, 23.2–NE). The objective response rates (ORRs) were PCb: 52.2%; PC: 46.2%. Grade 4 treatment-related toxicities (% PCb/% PC) were: anemia, 0/1.9; neutropenia, 6.5/3.8; thrombocytopenia, 4.3/1.9; and esophagitis, 0/1.9. Most patients completed scheduled chemotherapy and RT during induction and consolidation phases. No drug-related deaths were reported during chemoradiotherapy. Conclusions: Because of study design, efficacy comparisons cannot be made. However, both combinations with concurrent RT were active and well tolerated.
Musculoskeletal problems and quality of life of elementary school teachers

Purpose: To investigate prevalence and anatomical distribution of musculoskeletal pain (MSP) and its impact on quality of life (QoL) in elementary school teachers working in Muğla town center. Methods: Physical, sociodemographic and occupational characteristics of 104 teachers were recorded. Onset, prevalence and consequences of MSP (Extended Nordic Musculoskeletal Questionnaire) and QoL (Short Form-36 Health Survey) of teachers with (n = 37) and without (n = 67) MSP during the last 12 months were compared. Results: The prevalence of MSP was 77% for the lifelong period and 36% for the last 12 months. Physical and sociodemographic characteristics, daily employment period and length of standing and sitting were similar between groups (p > 0.05). The most common painful regions were the neck (39%) and the lower back (38%). MSP of these regions was the common reason for seeking healthcare, prevention from activities and taking sick leave. MSP had negative impact, especially on the physical components of QoL (p < 0.05). Conclusions: The results reveal high prevalence of MSP among teachers, as well as its negative impacts on QoL. Especially neck and lower back seem to be the most frequently affected regions of the body. These findings draw attention toward the need for developing strategies to prevent MSP among teachers.
Left Phrenic Nerve Injury during Cryoballoon Ablation of the Left Superior Pulmonary Vein

Transcatheter ablation of the pulmonary veins (PVs) has been established as a therapeutic option for patients with symptomatic atrial fibrillation. Cryothermal energy is an alternative energy source that has been developed to overcome some of the disadvantages of radiofrequency ablation. The major complication of the cryoballoon technique seems to be right‐sided phrenic nerve injury (PNI) following ablation of the right superior PV. This case report describes a left‐sided PNI after cryoballoon ablation of the left superior PV. (PACE 2012; 35:e334–e336)
Assessment of the effectiveness of modular clothing protecting against the cold based on physiological tests

At many workstations in a cold environment, protective clothing provided for the workers is characterized by inadequate thermal insulation, which results in an adverse impact of the cold environment on the worker's body. The purpose of this article is to present developed new ergonomic modular cold protective clothing, which allows for easy adaptation of the thermal insulation of clothing to a worker's individual needs. This clothing was compared in a laboratory study with the clothing having so far been used by workers in a cold environment using physiological and physical measurements, subjective ratings of the thermal state as well as a questionnaire for subjective assessment of the used clothing. These measurements and ratings confirmed that the modular cold protective clothing is more effective in the process of ensuring thermal comfort to the wearer during work in a cold environment than the clothing having so far been used.
Attitudes toward elderly workers and perceptions of integrated age management practices

This qualitative study investigates attitudes toward elderly workers and their work situation in different sectors, and explores perceptions and organizational measures that can enable an extended working life. Previous age management studies indicate that there are several interconnected measures and key areas of importance, and that there is a general need for strategies to strengthen sustainable age management at the organizational level. A structured content analysis was used to analyze data from focus group interviews with informants from a variety of organizations. The study identified three themes that highlight attitudes and perceptions of integrated age management practices: (a) contemporary policies and practices in the work environment; (b) social participation and attitudes; (c) experience and mentorship. These themes can form the basis of a good approach to an integrated age management strategy. Such a strategy can be achieved through intervention studies where research on sustainable working life meets the real problems faced by employees and managers.
Stop-and-go, stepwise and "ligand-free" nucleation, nanocrystal growth and formation of Au-NPs in ionic liquids (ILs).

Ionic liquids function as a nanosynthetic template for a "ligand-free" stepwise formation of gold nanoparticles (Au-NPs) which can be stopped and resumed at different color steps and Au-NP sizes (between 2.6 and 200 nm median diameter) and which can be reasoned by the DFT-calculation stabilization order: H(2)O (no Au-NP stabilization) < IL anion, e.g. BF(4)(-) approximately = PH(3) < citrate
Is there a future for the use of non-traditional placement settings for final year social work students?

This paper describes the development of a particular type of nontraditional placement setting for final year social work students: a 100 day, last practice placement based within Police Public Protection Investigation Units (PPIUs) through collaboration between the Police and Manchester Metropolitan University. It will evaluate the degree of progress made since these placements began in 2007 and consider some of the strengths and difficulties encountered in providing consistently good quality practice learning experiences for final year students within PPIU settings. The paper will summarise the learning gained from a recent evaluation of these placements and will describe some of the developments that have resulted from this evaluation.This paper will also consider whether such non-traditional placement settings can continue to provide suitable practice learning opportunities for final year social work students in the light of the newly proposed placement criteria for final placements (TCSW, 2012a) and in the increasingly challenging climate for practice learning reflected in the continuing decreased availability of ‘statutory’ placements.
An energy‐efficient algorithm based on sleep‐scheduling in IP backbone networks

This paper relates to the problem of energy conservation in Internet backbone networks. We propose a new Distributed Green Algorithm based on Sleep‐scheduling (DGAS) to switch off some network links and nodes resulting in less energy consumption. Our solution does not depend on any centralized controller and uses a link‐state protocol like Open Shortest Path First to share required information. In addition, DGAS does not require any knowledge of traffic matrix and switches off network nodes and links in 2 phases. In the first phase, some core nodes are switched off on the basis of their usage in network paths. In the second phase, DGAS starts with a minimal topology on the basis of resulted topology from the first phase and adds some links to it to minimize network paths length. Results, obtained by several real network scenarios, show that DGAS can switch off up to 27% of core nodes and up to 80% of links compared to the maximum number of switchable links.
Knowledge of HPV Among United States Hispanic Women: Opportunities and Challenges for Cancer Prevention

In the United States, Hispanic women contribute disproportionately to cervical cancer incidence and mortality. This disparity, which primarily reflects lack of access to, and underutilization of, routine Pap smear screening may improve with increased availability of vaccines to prevent Human Papillomavirus (HPV) infection, the principal cause of cervical cancer. However, limited research has explored known determinants of HPV vaccine acceptability among Hispanic women. The current study examines two such determinants, HPV awareness and knowledge, using data from the 2007 Health Interview National Trends Survey (HINTS) and a cross-section of callers to the National Cancer Institute's (NCI) Cancer Information Service (CIS). Study data indicate that HPV awareness was high in both samples (69.5% and 63.8% had heard of the virus) but that knowledge of the virus and its association with cervical cancer varied between the two groups of women. The CIS sample, which was more impoverished and less acculturated than their HINTS counterparts, were less able to correctly identify that HPV causes cervical cancer (67.1% vs. 78.7%) and that it is a prevalent sexually transmitted infection (STI; 66.8% vs. 70.4%). Such findings imply that future research may benefit from disaggregating data collected with Hispanics to reflect important heterogeneity in this population subgroup's ancestries, levels of income, educational attainment, and acculturation. Failing to do so may preclude opportunity to understand, as well as to attenuate, cancer disparity.