Miracle-dz/UniFAR-FTUs huggingface dataset:
Detection Reliability and Throughput Analysis for Cooperative Spectrum Sensing in Cognitive Radio Networks

In cognitive radio networks (CRNs), cooperative spectrum sensing technology could overcome the impact from shadow fading and noise uncertainty; however, cognitive radio users with different signal-to-noise ratios (SNRs) would cause the unreliable detection performance when making a decision in the information fusion center. Therefore, a novel cooperative spectrum sensing scheme which focus on the reliability of cognitive radio users is presented. The proposed approach does not select all of the cognitive radio users but the ones whose SNR is beyond the average SNR of the whole users for high reliability. Moreover, the detection and throughput performance is investigated. Simulation results illustrate this approach could enhances the detection probability by comparing to the conventional cooperative algorithm. Besides, it also could lead to higher throughput within a short spectrum sensing time.
Using Storytelling to Elicit Design Guidance for Medical Devices

Medical device designers must understand the complex context of use within a health care environment to ensure product usability. Designers must overcome domain-specific obstacles during usability research, such as patient privacy standards, which prevent designers from observing practitioners in context. In this project, we investigated storytelling as an alternative elicitation method for medical device requirements when direct observations are limited or not possible. While gathering requirements for an infusion pump, we compared the types of information elicited by focus groups, interviews, and storytelling sessions. Several advantages and implications for the use of storytelling in usability research are discussed.
Requirement to change of functional brain network across the lifespan

Many studies have focused on neural changes and neuroplasticity, while the signaling demand for neural modification needs to be explored. In this study, we traced this issue in the organization of brain functional links where the conflictual arrangement of signed links makes a request to change. We introduced the number of frustrations (unsatisfied closed triadic interactions) as a measure for assessing "requirement to change" of functional brain network. We revealed that the requirement to change of the resting-state network has a u-shape functionality over the lifespan with a minimum in early adulthood, and it’s correlated with the presence of negative links. Also, we discovered that brain negative subnetwork has a special topology with a log-normal degree distribution in all stages, however, its global measures are altered by adulthood. Our results highlight the study of collective behavior of functional negative links as the source of the brain’s between-regions conflicts and we propose exploring the attribute of the requirement to change besides other neural change factors.
Response of Rhodococcus cerastii IEGM 1278 to toxic effects of ibuprofen

The article expands our knowledge on the variety of biodegraders of ibuprofen, one of the most frequently detected non-steroidal anti-inflammatory drugs in the environment. We studied the dynamics of ibuprofen decomposition and its relationship with the physiological status of bacteria and with additional carbon and energy sources. The involvement of cytoplasmic enzymes in ibuprofen biodegradation was confirmed. Within the tested actinobacteria, Rhodococcus cerastii IEGM 1278 was capable of complete oxidation of 100 μg/L and 100 mg/L of ibuprofen in 30 h and 144 h, respectively, in the presence of an alternative carbon source (n-hexadecane). Besides, the presence of ibuprofen induced a transition of rhodococci from single- to multicellular lifeforms, a shift to more negative zeta potential values, and a decrease in the membrane permeability. The initial steps of ibuprofen biotransformation by R. cerastii IEGM 1278 involved the formation of hydroxylated and decarboxylated derivatives with higher phytotoxicity than the parent compound (ibuprofen). The data obtained indicate potential threats of this pharmaceutical pollutant and its metabolites to biota and natural ecosystems.
Theta Dynamics Contribute to Retrieving Motor Plans after Interruptions in the Primate Premotor Area

Abstract To achieve a behavioral goal, we often need to maintain an internal action plan against external interruption and thereafter retrieve the action plan. We recently found that the maintenance and updating of motor plans are reflected by reciprocal changes in the beta and gamma power of the local field potential (LFP) of the primate medial motor areas. In particular, the maintenance of the immediate motor plan is supported by enhanced beta oscillations. However, it is unclear how the brain manages to maintain and retrieve the internal action plan against interruptions. Here, we show that dynamic theta changes contribute to the maintenance of the action plan. Specifically, the power of the theta frequency band (4–10 Hz) of LFPs increased before and during the interruption in the dorsal premotor areas in two monkeys. Without theta enhancement before the interruption, retrieval of the internal action plan was impaired. Theta and beta oscillations showed distinct changes depending on the behavioral context. Our results demonstrate that immediate and suspended motor plans are supported by the beta and theta oscillatory components of LFPs. Motor cortical theta oscillations may contribute to bridging motor plans across behavioral interruptions in a prospective manner.
Inactive status is an independent predictor of liver transplant waitlist mortality and is associated with a transplant centers median meld at transplant

Background Approximately 30% of patients on the liver transplant waitlist experience at least one inactive status change which makes them temporarily ineligible to receive a deceased donor transplant. We hypothesized that inactive status would be associated with higher mortality which may differ on a transplant centers’ or donor service areas’ (DSA) Median MELD at Transplant (MMaT). Methods Multi-state models were constructed (OPTN database;06/18/2013-06/08/2018) using DSA-level and transplant center-level data where MMaT were numerically ranked and categorized into tertiles. Hazards ratios were calculated between DSA and transplant center tertiles, stratified by MELD score, to determine differences in inactive to active transition probabilities. Results 7,625 (30.2% of sample registrants;25,216 total) experienced at least one inactive status change in the DSA-level cohort and 7,623 experienced at least one inactive status change in the transplant-center level cohort (30.2% of sample registrants;25,211 total). Inactive patients with MELD≤34 had a higher probability of becoming re-activated if they were waitlisted in a low or medium MMaT transplant center or DSA. Transplant rates were higher and lower re-activation probability was associated with higher mortality for the MELD 26–34 group in the high MMaT tertile. There were no significant differences in re-activation, transplant probability, or waitlist mortality for inactivated patients with MELD≥35 regardless of a DSA’s or center’s MMaT. Conclusion This study shows that an inactive status change is independently associated with waitlist mortality. This association differs by a centers’ and a DSAs’ MMaT. Prioritization through care coordination to resolve issues of inactivity is fundamental to improving access.
A novel route for identifying starch diagenetic products in the archaeological record

This work introduces a novel analytical chemistry method potentially applicable to the study of archaeological starch residues. The investigation involved the laboratory synthesis of model Maillard reaction mixtures and their analysis through Fourier-Transform Ion Cyclotron Resonance Mass Spectrometry (FTICR-MS). Thus, starch from sixteen plant species were matured while reacting it with the amino acid glycine. The FTICR-MS analysis revealed > 5,300 molecular compounds, with numerous unique heteroatom rich compound classes, ranging from 20 (Zea mays) to 50 (Sorghum bicolor). These classes were investigated as repositories of chemical structure retaining source and process-specific character, linked back to botanical provenance. We discussed the Maillard reaction products thus generated, a possible pathway for the preservation of degraded starch, while also assessing diagenetic recalcitrance and adsorption potential to mineral surfaces. In some cases, hydrothermal experimentation on starches without glycine reveals that the chemical complexity of the starch itself is sufficient to produce some Maillard reaction products. The article concludes that FTICR-MS offers a new analytical window to characterize starchy residue and its diagenetic products, and is able to recognize taxonomic signals with the potential to persist in fossil contexts.
Down-regulation of cyclin D2 in amyloid β toxicity, inflammation, and Alzheimer’s disease

In the current study, we analyzed the effects of the systemic inflammatory response (SIR) and amyloid β (Aβ) peptide on the expression of genes encoding cyclins and cyclin-dependent kinase (Cdk) in: (i) PC12 cells overexpressing human beta amyloid precursor protein (βAPP), wild-type (APPwt-PC12), or carrying the Swedish mutantion (APPsw-PC12); (ii) the murine hippocampus during SIR; and (iii) Alzheimer’s disease (AD) brain. In APPwt-PC12 expression of cyclin D2 (cD2) was exclusively reduced, and in APPsw-PC12 cyclins cD2 and also cA1 were down-regulated, but cA2, cB1, cB2, and cE1 were up-regulated. In the SIR cD2, cB2, cE1 were found to be significantly down-regulated and cD3, Cdk5, and Cdk7 were significantly up-regulated. Cyclin cD2 was also found to be down-regulated in AD neocortex and hippocampus. Our novel data indicate that Aβ peptide and inflammation both significantly decreased the expression of cD2, suggesting that Aβ peptides may also contribute to downregulation of cD2 in AD brain.
Health problems and violence experiences of nurses working in acute care hospitals, long-term care facilities, and home-based long-term care in Germany: A systematic review

Background Working in the nursing sector is accompanied by great physical and mental health burdens. Consequently, it is necessary to develop target-oriented, sustainable profession-specific support and health promotion measures for nurses. Objectives The present review aims to give an overview of existing major health problems and violence experiences of nurses in different settings (acute care hospitals, long-term care facilities, and home-based long-term care) in Germany. Methods A systematic literature search was conducted in PubMed and PubPsych and completed by a manual search upon included studies’ references and health insurance reports. Articles were included if they had been published after 2010 and provided data on health problems or violence experiences of nurses in at least one care setting. Results A total of 29 studies providing data on nurses health problems and/or violence experience were included. Of these, five studies allowed for direct comparison of nurses in the settings. In addition, 14 studies provided data on nursing working in acute care hospitals, ten on nurses working in long-term care facilities, and four studies on home-based long-term care. The studies either conducted a setting-specific approach or provided subgroup data from setting-unspecific studies. The remaining studies did not allow setting-related differentiation of the results. The available results indicate that mental health problems are the highest for nurses in acute care hospitals. Regarding violence experience, nurses working in long-term care facilities appear to be most frequently affected. Conclusion The state of research on setting-specific differences of nurses’ health problems and violence experiences is insufficient. Setting-specific data are necessesary to develop target-group specific and feasible interventions to support the nurses’ health and prevention of violence, as well as dealing with violence experiences of nurses.
A new SPICE model of power P-I-N diode based on asymptotic waveform evaluation

A new SPICE subcircuit model for power p-i-n diodes is proposed in this paper. The model is based on a moment-matching approximation of the ambipolar diffusion equation. It is shown that both the quasistatic model and the lumped charge model can be obtained as ion-order moment-matching approximations while new and more accurate models can be obtained from higher-order solutions. The proposed model takes into account emitter recombination in the highly doped end regions, conductivity modulation in the base and the moving-boundaries effect during reverse-recovery, showing good convergence properties and fast simulation times. Comparisons between the results of the SPICE model and both numerical device simulations and experimental results are presented.
Factors affecting weekday-to-weekend sleep differences among Korean adolescent students: Focus on extracurricular tutoring time

Objectives Discrepancy in weekday-weekend sleep induces negative effects on physical health, obesity, psychological disorders, and academic performance; this particularly affects adolescent students through extracurricular tutoring, including evening self-study, private tutoring, and home studies. The present research aimed to clarify sociodemographic and economic factors, including extracurricular tutoring time, associated with weekday-to-weekend sleep differences using longitudinal data. Study design Data from the Korean Children and Youth Panel Survey (KCYPS) data were analyzed. Weekday-to-weekend sleep differences and extracurricular tutoring, as well as other covariates, were measured using adolescent’s self-report questionnaires. Multilevel regression and structural equation modeling (SEM) of repeated measures were used to test the hypothesized relationship between variables. Results The time spent in weekly extracurricular tutoring was negatively associated with weekday-to-weekend sleep differences. However, increased tutoring time was positively associated with bedtime, and bedtime was in turn positively associated with differences in Korean adolescents’ weekday-to-weekend sleep patterns. The SEM analysis result showed a significant indirect effect of tutoring time on sleep differences via bedtime. Conclusions Limiting weekly extracurricular tutoring time is important to early bedtime and reducing weekday-to-weekend sleep pattern differences. Policymakers should develop alternatives to private tutoring to improve the sleep duration and reduce weekday-to-weekend sleep differences among adolescents.
NAD+ bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells

Abstract Elevated expression of the DNA damage response proteins PARP1 and poly(ADP-ribose) glycohydrolase (PARG) in glioma stem cells (GSCs) suggests that glioma may be a unique target for PARG inhibitors (PARGi). While PARGi-induced cell death is achieved when combined with ionizing radiation, as a single agent PARG inhibitors appear to be mostly cytostatic. Supplementation with the NAD+ precursor dihydronicotinamide riboside (NRH) rapidly increased NAD+ levels in GSCs and glioma cells, inducing PARP1 activation and mild suppression of replication fork progression. Administration of NRH+PARGi triggers hyperaccumulation of poly(ADP-ribose) (PAR), intra S-phase arrest and apoptosis in GSCs but minimal PAR induction or cytotoxicity in normal astrocytes. PAR accumulation is regulated by select PARP1- and PAR-interacting proteins. The involvement of XRCC1 highlights the base excision repair pathway in responding to replication stress while enhanced interaction of PARP1 with PCNA, RPA and ORC2 upon PAR accumulation implicates replication associated PARP1 activation and assembly with pre-replication complex proteins upon initiation of replication arrest, the intra S-phase checkpoint and the onset of apoptosis.
The prediction of fluctuation in the order-driven financial market

Risk prediction is one of the important issues that draws much attention from academia and industry. And the fluctuation—absolute value of the change of price, is one of the indexes of risk. In this paper, we focus on the relationship between fluctuation and order volume. Based on the observation that the price would move when the volume of order changes, the prediction of price fluctuation can be converted into the prediction of order volume. Modelling the trader’s behaviours—order placement and order cancellation, we propose an order-based fluctuation prediction model. And our model outperforms better than baseline in OKCoin and BTC-e datasets.
The Incidence of Endoscopic Retrograde Cholangiopancreatography-Related Complications in Patients With Liver Transplant: A Meta-Analysis and Systematic Review

Background Existing literature on post-endoscopic retrograde cholangiopancreatography (ERCP) complications in patients with liver transplant remains scarce and largely inconsistent. We therefore aimed to systematically review and analyze the literature on complication rates associated with ERCP in patients with liver transplant. Methods We performed a comprehensive literature search in PubMed, PubMed Central, Embase, and ScienceDirect databases from inception through March 2020 to identify all the studies that evaluated post-ERCP complications in patients with liver transplant. Effect estimates from the individual studies were extracted and combined using the random effect, generic inverse variance method of DerSimonian and Laird, and a pooled odds ratio (OR) and event rates were calculated. Forest plots were generated, and publication bias was assessed for using conventional techniques. Results Fourteen studies with a total of 1,787 patients were analyzed. In total, 3,192 ERCPs were performed on these patients. The pooled all-complication rate was 5.2% (95% confidence interval (CI): 0.035 - 0.075). Procedural complications analyzed included post-ERCP pancreatitis 3.4% (95% CI: 0.025 - 0.047), bleeding 1.1% (95% CI: 0.006 - 0.020), infections 0.2% (95% CI: 0.025 - 0.047), and cholangitis 0.8% (95% CI: 0.004 - 0.020). No cases of periprocedural death were reported. The pooled OR for post-ERCP pancreatitis in patients with liver transplant compared to patients without liver transplant was 1.289 (95% CI: 0.455 - 3.653, P = 0.633, I2 = 72.88%). Conclusion Post-ERCP complication rates in liver transplant patients are comparable to the general population and hence, peri-procedural evaluation and management may follow the current standards of care in this patient population.
Persistence of sleep difficulties for over 16 years amongst 66,948 working-aged adults

The objective was to investigate the persistence of sleep difficulties for over 16 years amongst a population of working age. In this prospective cohort study, a group-based trajectory analysis of repeated surveys amongst 66,948 employees in public sector (mean age 44.7 [SD 9.4] years, 80% women) was employed. The main outcome measure was sleep difficulties based on Jenkins Sleep Scale (JSS). Up to 70% of the respondents did not experience sleep difficulties whereas up to 4% reported high frequency of notable sleep difficulties through the entire 16-year follow-up. Heavy drinking predicted sleep difficulties (OR 2.3 95% CI 1.6 to 3.3) except for the respondents younger than 40 years. Smoking was associated with sleep difficulties amongst women younger than 40 years (OR 1.2, 95% CI 1.0 to 1.5). Obesity was associated with sleep difficulties amongst men (OR 1.9, 95% CI 1.4 to 2.7) and women (OR 1.2, 95% CI 1.1 to 1.3) of middle age and amongst women older than 50 (OR 1.5, 95% CI 1.2 to 1.8) years. Physical inactivity predicted sleep difficulties amongst older men (OR 1.3, 95% CI 1.1 to 1.6). In this working-age population, sleep difficulties showed a great persistence over time. In most of the groups, the level of sleep difficulties during the follow-up was almost solely dependent on the level of initial severity. Depending on sex and age, increasing sleep problems were sometimes associated with high alcohol consumption, smoking, obesity and physical inactivity, but the strength of these associations varied.
Inkjet printed fine silver electrodes for all-solution-processed low-voltage organic thin film transistors

Inkjet printed silver (IJP Ag) source/drain (S/D) and gate electrodes were incorporated into a bottom-gate bottom-contact organic thin film transistor (OTFT) architecture to develop all-solution-processed low voltage OTFTs. With well controlled ink wetting on a cross-linked polyvinyl-alcohol surface, IJP Ag S/D electrode pairs were fabricated with controllable short channels down to 20 μm using a Dimatix 2831 inkjet printer with a 10 pL cartridge, and formed good contacts with the organic semiconductor layer. IJP gate electrodes with a low flat surface profile were also achieved to obtain OTFTs of high quality gate dielectric layer for low leakage current. The fabricated low voltage all-solution-processed OTFTs present good device performance with a low operation voltage below 2 V, a mobility of 0.3 cm2 V−1 s−1, and an ON/OFF current ratio larger than 104.
Optimizing Counter-terroristic Operations in an Asymmetric Lanchester Model

Abstract Effective counter-terroristic operations require efficient intelligence. Recently, Kress and Szechtmann (2009) analyzed the impact of the level of intelligence to the outcome of a fight between the government and a small insurgent group in a descriptive, asymmetric Lanchester-style model. The present paper uses optimal control theory, particularly Pontryagin's maximum principle, to find the optimal intelligence policy and recruitment rate of the government forces. In particular, we intend to study multiple long-run steady states and complex behavior of the optimal solution paths. Moreover, a differential game between the government and the terrorist is proposed.
Unexpected Nectriaceae species diversity in cheese, description of Bisifusarium allantoides sp. nov., Bisifusarium penicilloides sp. nov., Longinectria gen. nov. lagenoides sp. nov. and Longinectria verticilliforme sp. nov

Investigation of various cheese rinds for Bisifusarium domesticum revealed a completely unexpected diversity of Fusarium-like fungi. Elongation factor 1-alpha gene sequence data, classically used for Fusarium spp. identification, suggested that some isolates corresponded to so far undescribed Nectriaceae species. In this context, a multi-gene phylogenetic analysis, based on ten loci, namely the large subunit of the ATP citrate lyase (acl1), alpha-actin (act), calmodulin (cmdA), histone H3 (his3), the internal transcribed spacer region and intervening 5.8S nrRNA (ITS), 28S large subunit (LSU), RNA polymerase II largest subunit (rpb1), RNA polymerase II second largest subunit (rpb2), translation elongation factor 1-alpha (tef1) and β-tubulin (tub2), was therefore performed to determine the phylogenetic position of ten cheese and one environmental isolates. Phylogenetic reconstructions were then done using a Nectriaceae sequence dataset. Additionally, morphological observations as well as metabolite profiling were performed. Results clearly revealed the existence of four novel cheese-associated species, namely Bisifusarium allantoides, Bisifusarium penicilloides, Longinectria lagenoides, Longinectria verticilliforme, the two latter belonging to a novel genus (Longinectria gen. nov.).