Miracle-dz/UniFAR-FTUs huggingface dataset:
Manufacturing Industry Cancer Risk in Japan: A Multicenter Hospital-Based Case Control Study

Background: It is well known that specific occupations can cause harm in developing malignant neoplasms. Chemical exposure is particularly high in the manufacturing industry and workers in this sector may face a higher occupational risk for cancer. We aimed to estimate inequalities in the risk of cancers related to occupational chemical exposure in various manufacturing categories. Methods: Using nationwide clinical inpatient data (1984−2017) in Japan, we undertook a multicenter, case-control study with regard to risks of developing cancers among various manufacturing industry categories. Using the food manufacturing industry as the reference group, odds ratios and 95% confidence intervals for each industry were estimated by conditional logistic regression, adjusted for sex, age, admission period, and the admitting hospital. Medical record summaries accounting for 89% of industrial categories with high odds ratios were collected to confirm diagnoses made on the basis of histology. We estimated industrial hazards based on the Pollutant Release and Transfer Register. Results: A reduced risk for some of common cancers was observed among lumber and wood products industries. Leather tanning, leather products and fur tended to show a higher risk: 2.36 (95% CI 1.15−4.83) for pancreatic cancer, 2.85 (95% CI 1.26−6.47) for liver cancer and 2.00 (95% CI 1.01–3.99) for lung cancer. For the electronics category, observations of high risk ranged from 2.09 (95%CI 1.18–3.70) for ureter cancer, to 2.49 (95% CI 1.79–3.55) for kidney cancer. Conclusions: This study revealed industry risk inequalities in manufacturing categories were present with regard to the risk of common cancers in Japan.
A Multicentered Study of the Clinical and Molecular Epidemiology of TEM- and SHV-type Extended-Spectrum Beta-Lactamase Producing Enterobacterales Infections in Children

Background: Extended-spectrum β-lactamase (ESBL)-producing Enterobacterales-(Ent) infections are increasing in pediatrics. Before CTX-M ESBL emerged, the most common infection-associated ESBL genes were TEM and SHV-type ESBLs. We sought to define the current epidemiology of Ent infections in children due to blaTEM and blaSHV (TEM-SHV-Ent). Methods: A retrospective case-control analysis of children with TEM-SHV-Ent infections at 3 Chicago-area hospitals was performed. Cases had extended-spectrum-cephalosporin (ESC)-resistant infections due to blaTEM or blaSHV. DNA analysis assessed β-lactamase (bla) genes, multilocus sequence types, and E. coli phylogenetic grouping. Controls had ESC-susceptible Ent infections, matched 3:1 to cases by age, source, and hospital. Clinical-epidemiologic infection predictors were assessed. Results: Of 356 ESC-R-Ent isolates from children (median 4.3 years), 38 (10.7%) were positive solely for blaTEM-ESBL (26%) or blaSHV-ESBL genes (74%). Predominant organisms were Klebsiella (34.2%) and E. coli (31.6%); 67% of E. coli were phylogroup B2. Multilocus sequence types revealed multiple strains, 58% resistant to ≥3 antibiotic classes. On multivariable analysis, children with TEM-SHV-Ent infections more often had recent inpatient care (OR, 8.2), yet were diagnosed mostly as outpatients (OR, 25.6) and less in Neonatal Intensive Care Units (OR, 0.036) than controls. TEM-SHV-Ent patients had more gastrointestinal (OR, 23.7) and renal comorbidities (OR, 4.2). Differences in demographics, antibiotic exposure, and foreign bodies were not found. Conclusion: TEM-SHV-Ent are commonly linked to inpatient exposures in children with chronic conditions but most often present in outpatient settings. Clinicians should be aware of the potential increased risk for TEM-SHV-Ent infections in outpatients with gastrointestinal and renal comorbidities and histories of prolonged hospital stays.
Kidney and Marrow Fat as Indicators of White-Tailed Deer Condition

Comparisons of kidney fat indices and fat content of femur marrow from 34 female whitetailed deer (Odocoileus virginianus) showed that kidney fat is not a reliable indicator of physical condition during mobilization of femur marrow fat. A method involving the complementary use of the two measurements is suggested as a means of assessing physical condition over its entire range. This paper shows the relationship of kidney fat indices to the fat content of femur marrow in female white-tailed deer and presents a method for the complementary use of the two measurements in assessing physical condition. Riney (1955) studied various methods of evaluating the condition of red deer (Cervus elaphus) in New Zealand and concluded that weight of kidney fat expressed as a percentage of kidney weight is a valid index of total body fat over the entire range of physical condition. This method was applied to 66 female white-tailed deer collected in Manitoba from December, 1962, through April, 1963. The indices thus obtained decreased regularly over the winter until the second week of March when the poorest deer had indices as low as 8. But during the next month only 1 of 15 deer collected had an index below 8 although their general appearance indicated that several of the 15 were in poorer condition than any of those collected previously. Since Harris (1945) and Cheatum (1949) found that marrow fat is the last fat reserve to be mobilized in deer, I obtained the percentage of fat in femur marrow from 34 of the 66 deer to determine whether or not further deterioration in condition had escaped detection by the kidney fat index method. MATERIALS AND METHODS Kidney fat weights were obtained using a method described by Riney (1955) and an index for each animal was calculated using the fat from both kidneys in order to minimize variation. The percentage of fat in the central 2 inches of femur marrow 397 cent water. Of the dry matter about 75 percent is sucrose, and the balance includes salts of sodium and potassium plus nitrogenous compounds. In Table 1 the nutritional values of the sugar beet root and field corn are compared (Morrison, F. B. 1956. Feeds and feeding: A handbook for the student and stockman. 22nd ed. The Morrison Publishing Company, Ithaca, New York. vi+ 1165pp.). In recent years Canada geese have gradually been educated to feed on agricultural crops on the refuge and have thus developed a taste for sugar beets. From a nutritional standpoint, sugar beet roots and crowns rate considerably lower than field corn, but, at least during the dry season, they provide an important source of succulent browse. Received for publication March 26, 1964. This content downloaded from 157.55. 39.249 on Wed, 03 Aug 2016 05:23:52 UTC All use subject to http://about.jstor. org/terms 398 Journal of Wildlife Management, Vol. 29, No. 2, April 1965
Molecular Characterization of the Complete Coding Sequence of Olive Leaf Yellowing-Associated Virus

Genome organization and phylogenetic relationships of olive leaf yellowing-associated virus (OLYaV) with other members of the Closteroviridae family were determined. The complete coding sequence of OLYaV was obtained by high throughput sequencing of total RNA from a 35-year-old olive tree (cv. Zarzaleña) from Brazil, showing olive leaf yellowing disease and deformations in the wood. This represents the first report of OLYaV in this country. A genomic sequence of 16,700 nt containing 11 open reading frames (ORFs) was recovered, representing the complete virus coding capacity. The knowledge of the nucleotide sequence of the genome including the gene that codes the coat protein will facilitate the development of diagnostic tests, which are limited so far to PCR-based methods targeting the HSP70h gene. Interestingly, a thaumatin-like protein (ORF2), previously reported in other unassigned viruses in the Closteroviridae family, persimmon virus B and actidinia virus 1, was identified in the OLYaV genome. Phylogenetic analysis of shared proteins (ORF1a, ORF1b, HSP70h, HSP90h and CP) with all members of the Closteroviridae family provides new insight into the taxonomic position of these three closteroviruses and suggests they could represent a new genus in the family.
Non-invasive evaluation of obstruction after ureteroscopic stone removal: Role of renal resistive index assessment.

OBJECTIVES The aim of this study is to evaluate prediction of postoperative ureteral obstruction needing ureteral stent insertion by evaluating the resistive index (RI) values and the grade of hydronephrosis. MATERIAL AND METHODS A total of 66 adult patients undergoing stentless endoscopic ureteral stone treatment (URS) between January 2018 and January 2019 were included in this prospective study. Preoperative patient and stone characteristics were noted. All patients were evaluated with renal Doppler ultrasonography study to assess degree of hydronephrosis and RI values. A renal Doppler ultrasonography was repeated at postoperative 1st, 3rd and 7th days. Changes in both RI and hydronephrosis levels before and after the procedures were noted. On the postoperative 7th day, patients were divided into two groups including obstructive and non-obstructive cases according to RI values assessed where a RI value of 0.7 was accepted as the cut-off for obstruction. The preoperative and perioperative characteristics of both groups were evaluated in a comparative manner. RESULTS The mean patient age was 43.6 ± 1.72 years. Significant improvements were noted in RI and grade of hydronephrosis after the operation. The grade of hydronephrosis and RI values were found to improve more significantly on postoperative 3rd day when compared to the postoperative 7th day (p < 0.01 and p < 0.01). A significant correlation was detected between the grade of hydronephrosis (>grade 2) and obstructive RI values (> 0.7) in each postoperative visits (p: 0.001). RI values (> 0.7) at postoperative seventh days were correlated with larger mean stone size, increased ureteral wall thickness, increased diameter of the ureter proximal to the stone, and longer duration of the operation. Preoperative high-grade hydronephrosis indicated obstructive RI values at postoperative seventh day (p = 0.001) Conclusion: Changes in RI values on Doppler sonography and the grade of hydronephrosis may be a guiding parameter in assessing postoperative ureteral obstruction.
Tackling the Mouse‐on‐Mouse Problem in Cochlear Immunofluorescence: A Simple Double‐Blocking Protocol for Immunofluorescent Labeling of Murine Cochlear Sections with Primary Mouse Antibodies

The mouse is the most widely used animal model in hearing research. Immunohistochemistry and immunofluorescent staining of murine cochlear sections have, thus, remained a backbone of inner ear research. Since many primary antibodies are raised in mouse, the problem of “mouse‐on‐mouse” background arises due to the interaction between the anti‐mouse secondary antibody and the native mouse immunoglobulins. Here, we describe the pattern of mouse‐on‐mouse background fluorescence in sections of the postnatal mouse cochlea. Furthermore, we describe a simple double‐blocking immunofluorescence protocol to label mouse cochlear cryosections. The protocol contains a conventional blocking step with serum, and an additional blocking step with a commercially available anti‐mouse IgG blocking reagent. This blocking technique virtually eliminates the “mouse‐on‐mouse” background in murine cochlear sections, while adding only a little time to the staining protocol. We provide detailed instructions and practical tips for tissue harvesting, processing, and immunofluorescence‐labeling. Further protocol modifications are described, to shorten the duration of the protocol, based on the primary antibody incubation temperature. Finally, we demonstrate examples of immunofluorescence staining performed using different incubation times and various incubation temperatures with a commercially available mouse monoclonal primary antibody. © 2020 The Authors.
Efficiency of Percutaneous Stent Angioplasty in Renal Artery Stenosis – 15 Years of Experience at a Single Center

Abstract Purpose To determine the therapeutic efficiency of percutaneous revascularization in renal artery stenosis (RAS), as well as the role of comprehensive factors such as patient selection and degree of artery stenosis, on clinical outcome. Methods and Materials 101 patients with hemodynamically relevant RAS underwent percutaneous angioplasty (PTA). 65.7 % were male (mean age: 64 years; range: 18–84). The clinical data was retrospectively analyzed. The serum creatinine (Cr), glomerular filtration rate (GFR), and blood pressure (BP) levels pre- and postprocedural, between 6 months and 1 year, were retrospectively collected and statistically analyzed. Results Follow-up data was available in 34 (33.7 %) and 28 patients (27.7 %) for Cr and MAP, respectively. A significant drop in mean arterial pressure (MAP) was observed on follow-up (mean –5.27 mmHg). Higher baseline Cr and MAP values showed a more pronounced drop in the follow-up (Cr: p 0.002; difference to baseline –0.25 mg/dL, 95 %CI:–0.36, –0.07 and BP p < 0.001; diff. to baseline –0.72 mmHg; 95 %CI: –1.4, –0.40). There was no association between comorbidities, gender, and degree of stenosis with renal and BP outcome. No significant improvement in renal function was observed on follow-up (mean Cr drop: –0.015 mg/dL). The age group 51–60 years showed a significant improvement in BP (p 0.030; diff. to baseline –19.2 mmHg; 95 %CI: –34, –4.3). There was a slight reduction in antihypertensive medication following angioplasty (0.2 fewer). Minor complications were recorded in five procedures (4.9 %). Conclusion Percutaneous renal artery revascularization in the presence of atherosclerotic RAS is a safe procedure associated with a significant drop in post-procedural BP. No significant improvement in renal function was observed. Further prospective studies focused on patient selection are necessary. Key Points: Percutaneous stent angioplasty in renal artery stenosis is associated with a significant improvement in post-procedural blood pressure control. There is no improvement in renal function after percutaneous stent angioplasty for renal artery stenosis (RAS). Percutaneous stent angioplasty is a safe procedure. Citation Format Guerreiro H, Avanesov M, Dinnies S et al. Efficiency of Percutaneous Stent Angioplasty in Renal Artery Stenosis – 15 Years of Experience at a Single Center. Fortschr Röntgenstr 2021; 193: 298 – 304
Antibiotic Resistance and Prevalence of Enterococcus Spp. and Escherichia Coli Isolated from Bryndza Cheese

The study aimed at determining the prevalence antibiotic resistance of species – identified enterococci and Escherichia (E.) coli isolated from typical fresh Slovak cheese, bryndza. Antibiotic resistance of enterococci was determined by disk diffusion method. Of isolated enterococci, 240 were obtained from bryndza cheese. The first two decimal dilutions from 24 bryndza cheese samples purchased at supermarkets in Košice (0.1 mL) were spread on the surface of Slanetz and Bartley agar and incubated for 48±2 h at 37±1°C. Species identification of enterococci and E. coli was detected by means of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) based on bacterial protein profiling. The following species of enterococci were identified by MALDI-TOF MS: Enterococcus (Ent.) faecalis (22 strains), Ent. faecium (18 strains), Ent. sacharolyticus (6 strains), Ent. gilvus (4 strains), Ent. durans (9 strains), and Ent. casseliflavus (6 strains). All of the 45 E. coli strains and 74 strains of enterococci identified by MALDI-TOF MS were determined for occurrence of blaTEM, blaSHV and blaCTX-M genes. The results of our study suggest that the highest resistance of enterococci was on tetracycline (29.73%) and any resistance was recorded on vancomycin (0%). The highest multidrug-resistance was recorded on two antibiotics (32.43%). Neither one isolate of enterococci was resistant to all 6 antibiotics used in the experiment. In total, 19 (42.22%) E. coli were found to be producers of extended-spectrum β-lactamase.
Fecal Microbiota Alterations and Small Intestinal Bacterial Overgrowth in Functional Abdominal Bloating/Distention

Background/Aims The pathophysiology of functional abdominal bloating and distention (FABD) is unclear yet. Our aim is to compare the diversity and composition of fecal microbiota in patients with FABD and healthy individuals, and to evaluate the relationship between small intestinal bacterial overgrowth (SIBO) and dysbiosis. Methods The microbiota of fecal samples was analyzed from 33 subjects, including 12 healthy controls and 21 patients with FABD diagnosed by the Rome IV criteria. FABD patients underwent a hydrogen breath test. Fecal microbiota composition was determined by 16S ribosomal RNA amplification and sequencing. Results Overall fecal microbiota composition of the FABD group differed from that of the control group. Microbial diversity was significantly lower in the FABD group than in the control group. Significantly higher proportion of Proteobacteria and significantly lower proportion of Actinobacteria were observed in FABD patients, compared with healthy controls. Compared with healthy controls, significantly higher proportion of Faecalibacterium in FABD patients and significantly higher proportion of Prevotella and Faecalibacterium in SIBO (+) patients with FABD were found. Faecalibacterium prausnitzii, was significantly more abundant, but Bacteroides uniformis and Bifidobacterium adolescentis were significantly less abundant in patients with FABD, compared with healthy controls. Significantly more abundant Prevotella copri and F. prausnitzii, and significantly less abundant B. uniformis and B. adolescentis were observed in SIBO (+) patients, compared with healthy controls. Conclusion The fecal microbiota profiles in FABD patients are different from those in healthy controls, particularly in SIBO (+) patients, suggesting a role of gut microbiota in the pathogenesis of FABD.
Effects of GA3+4 and GA4+7 Application Either Alone or Combined with Prohexadione-Ca on Fruit Development of Japanese Pear ‘Kosui’

In order to promote increases in the size of ‘Kosui’ Japanese pear [Pyrus pyrifolia (Burm.) Nakai] fruit by plant growth regulators, we applied gibberellin (GA)3+4 paste [2.7% (w/w), A3:A4 = 90:10] in combination with prohexadione-calcium [1%, PCa; BAS-125 (3-oxido-4-propionyl-5-oxo-3-cyclohexene-carboxylate)], an inhibitor of GA 2β-hydroxylation that catabolizes active GA into an inactive form, to fruit pedicels at approximately 30 days after full bloom. GA3+4+PCa treatment advanced fruit growth only in the early stages, but fruit weight did not show any significant differences between the untreated control and GA3+4+PCa-treated fruits at harvest. In contrast, when GA4+7 [2.7% (w/w), A4:A7 = 66:34] was applied, the fruit weight at harvest was greater than that of untreated fruit. Moreover, GA4+7 treatment in combination with PCa resulted in an even higher fruit weight at harvest. The GA4 concentration in fruit flesh was not affected by GA3+4 application at 1 week after the treatment (WAT) either with or without PCa, but GA4 levels increased with GA4+7+PCa treatment, resulting in a significant increase in fruit weight at harvest. A single GA4+7 application almost doubled the GA4 concentration compared with the untreated control, but the difference was not significant. These results indicate that fruit weight at harvest was greater when the GA4 concentration was higher in the fruit flesh at 1 WAT. The higher concentration of GA4 in the GA4+7+PCa-treated fruit compared with the GA4+7 treatment alone may be attributed to the function of PCa that acts to prevent the inactivation of GA4 to GA34 by inhibiting 2β-hydroxylation.
The role of interpersonal emotional regulation on maternal mental health

ABSTRACT Purpose Symptoms of depression and anxiety during the perinatal period have a negative impact on mothers and their developing children. A significant body of research has demonstrated an association between mental health and both individual and interpersonal emotion regulation. Yet, this association has not been studied during the perinatal period. The aim of this study was to explore the association between emotion regulation, maternal mental health, and interpersonal emotion regulation during the transition to motherhood in a sample of Chilean women. Methods Women in their third trimester of pregnancy (n = 253) provided self-reports of emotion regulation and symptoms of depression and anxiety during pregnancy and three months postpartum. Additional self-reports of interpersonal emotion regulation were obtained from individuals who were identified as social support persons by these women. Results: Maternal emotion regulation contributed to maternal symptoms of depression and anxiety during pregnancy and after childbirth. The association between emotion regulation and maternal mental health was moderated by specific interpersonal emotion regulation strategies reported by the participant’s social support persons. Strategies including modulating the emotional response, situation modification, attentional deployment and cognitive change, modified the association between poor regulation strategies and anxiety symptoms. Also, an infrequent use of these interpersonal emotion regulation strategies strengthened the association between these maternal emotional regulation difficulties and anxiety symptoms. Conclusion Our findings suggest that interpersonal emotional regulation strategies impact the association of maternal emotional regulation strategies and maternal emotional wellbeing.
Association between Lifestyle Behaviors and Health-Related Quality of Life in a Sample of Brazilian Adolescents

This study aimed to analyze the association between lifestyle behaviors and health-related quality of life (HRQoL) among Brazilian adolescents. We evaluated 739 adolescents (51.0% girls; mean age, 16.4 ± 1.0 years) from the mesoregion Grande Florianópolis, Brazil. Participants were asked to complete an online questionnaire and sex, age, mother’s education, health-related quality of life, physical activity, screen time indicators, sleep duration, diet, cigarette smoking, alcohol drinking, and drug experimentation were retrieved. Health-related quality of life was assessed using the Kidscreen-10 instrument. Measures of body mass and height were taken by trained researchers. Mixed-effects linear regression models were used. Self-reported health-related quality of life was higher in males (β = 3.68, 95%CI: 2.75; 4.61) compared to females, and no association was observed for age and mother’s education level. Practicing sports (β = 1.19, 95%CI: 0.29; 2.08) was associated with better HRQoL, while processed food score (β = −0.45, 95%CI: −0.78; −0.13), working using screen devices for more than 4 h/day (β = −2.38, 95%CI: −4.52; −0.25), having experimented illicit drugs (β = −2.05, 95%CI: −3.20; −0.90), and sleeping less than 8 h/night (β = −1.35, 95%CI: −2.27; −0.43) were unfavorably associated with HRQoL. Non-sport physical activities, unprocessed food, studying, watching videos, playing videogames, using social media, alcohol drinking, and smoking were not associated with health-related quality of life. These findings suggest that promoting sports and adequate sleep, and preventing excessive workloads and the use of drugs among adolescents may be effective strategies to improve HRQoL.