Miracle-dz/UniFAR-FTUs huggingface dataset:
The impact of the construction health and safety regulatory framework on construction costs.

Historically, the construction industry has a poor health and safety (H&S) performance track record, and governments and industry bodies globally acknowledged that construction has an undesirable accident record and that persistently poor H&S records continue to hinder performance improvement. In response, H&S regulations have been introduced and subjected to major revisions during the last four decades as H&S regulations have been seen to be crucial to reducing construction accidents and improving H&S performance overall. Arguably, there has been resistance from the industry to fully implement the provisions of the legislation because of the perception particularly of contractors that the associated costs may result in noncompetitive bidding resulting in lost work opportunities and that there was still non-facilitation of equitable pricing of H&S within the construction industry. Since the introduction of very specific H&S regulations in the South African construction industry, there are, as far as the researcher is aware, very few, if any, studies which have quantified the cost of the implementation of the provisions of this legislation. The research was done to investigate the magnitude of the additional construction costs as a result of the implementation of the provisions of the current H&S regulatory framework in South Africa resulting in all construction project participants not being aware of how much would be adequate for the H&S provisions required. The purpose of the research was to determine whether the H&S framework had requirements that involve cost, whether contractors implemented the requirements of the H&S framework, whether implementation of the H&S framework increased the cost of construction, and to what extent did the implementation of the H&S framework increase the cost of construction. A blended research approach was adopted which included both quantitative and qualitative methods such as questionnaire surveys and case studies which were then triangulated. A sample of 30 contractors were surveyed and 3 organisations were interviewed to determine the impact of the construction health and safety regulatory framework on construction costs. The research was limited because the findings were based on a sample of contractors in the KwaZulu-Natal Province, South Africa, the study was conducted over a period of twelve months and the study focused on the impact of the H&S regulatory framework implementation by the contractor only. The study did not include H&S costs pertaining to sustainable building, impact on indirect costs related to construction H&S, impact of H&S regulations pertaining to design and build projects and impact of standard forms of contract on the costs related to construction H&S. The findings provide an indication of the trend in financial allowance by industry practitioners for construction health and safety on their projects. The study found that complying with the provisions of the legislative framework namely OHS Act, Construction Regulations and…
Otorhinolaryngology-Head Neck Epidermoid cyst of external auditory canal presenting as canal atresia: A rare case report

We present the case of a 12-month-old male child who was brought to our hospital with complaints of left ear canal atresia. The child had normal hearing and development. Pre operative diagnosis of EAC atresia was made and atresioplasty was planned. During surgery, we found a cyst filling the EAC, which was obscuring the tympanic membrane, which was normal looking. Complete excision of cyst was done and it was reported as epidermal inclusion cyst. Child is on regular follow up with a normal looking EAC.
Motion Tracking and Abandoned Objects Detection using Video Surveillance

— Surveillance cameras are video cameras used for the purpose of observing an area. Sensitive areas need to be observed continuously for security reasons. The security of these areas shall not be depending on the size of an area but, shall be considered on the high priority of security. Before few decades this task was done by the humans, but now it is not possible for human to keep watch day and night (24x7) on such areas. We all know that there is massive increase in theft in either in one or more ways. Human can easily be distracted and, a small distraction is sufficient for thieves to break the security. System is proposed and presented using our own data set captured in laboratory datasets. The proposed system works on QVGA (Quarter Video Graphics Array) resolution at which most CCTV (closed circuit television) cameras operate and uses a simple mathematical model for detection of human and object. Proposed work is a combination of base works as 1: Real time video feed. 2: Discover frame from the video after fixed time interval. 3: Dual time background subtraction algorithm which periodically updates two sets of background. 4: Deriving a reference image. 5: Maintaining a Buffered Background image/frame. 6: Blob detection. 7: Motion Tracking. 8: Object tracking. 9: Detection and maintaining log of and Alarm signalling. An algorithm for tracking of abandoned objects even under occlusion is also proposed.
FACIAL RECOGNITION PERFORMANCE BASED ON THE LIGHTING SET-UP MODELS APPLIED TO HOME SECURITY DOOR ACCESS USING PRINCIPAL COMPONENT ANALYSIS AND RASPBERRY PI CONTROLLER

Security protects individuals, data, and properties together with its corresponding measures in line to the emerging application of technology like the face recognition. This study aims to test the effects of lighting models on the recognition performance along with different angles and distance applied for door access by providing signals to Raspberry PI Controller. The study built 240 training datasets and applied the best algorithms – Haar-Cascade for face detection, Principal Component Analysis for extraction, Support Vector Machine for classification and Euclidean Distance for recognition. The study tested the model with five subjects which then marked a score of 100% for fluorescent light, 74.65 % for candle light, and 88 % for flashlight with an average percentage accuracy of 89.5. The results implied an adverse recognition result influenced by the lighting conditions, the face angle positions and distance issues.
The exosome and trans-acting siRNAs regulate cuticular wax biosynthesis during Arabidopsis inflorescence stem development 1[W]

Summary: The exosome and small RNAs control cuticular wax biosynthesis during plant development ABSTRACT The primary aerial surfaces of land plants are covered with a cuticle, a protective layer composed of the cutin polyester matrix and cuticular waxes. Previously, we discovered a novel mechanism of regulating cuticular wax biosynthesis during Arabidopsis stem elongation that involves ECERIFERUM7 (CER7), a core subunit of the exosome. Because loss-of-function mutations in the CER7 result in reduced expression of wax biosynthetic gene CER3, we proposed that CER7 is involved in degrading an mRNA encoding a CER3 repressor. To identify this putative repressor , we performed a cer7 suppressor screen that resulted in the isolation of post-transcriptional gene silencing components RNA-DEPENDENT RNA POLYMERASE1 and SUPRESSOR OF GENE SILENCING3, indicating that small RNAs regulate CER3 expression. To establish the identity of the effector RNA species and determine whether these RNAs control CER3 transcript levels directly , we cloned additional genes identified in our suppressor screen and performed next generation sequencing of small RNA populations that differentially accumulate in the cer7 mutant in comparison to wild-type. Our results demonstrate that trans-acting small interfering RNA (tasiRNA) class of small RNAs are the effector molecules involved in direct silencing of CER3 , and that the expression of five additional genes ( ERD14, SUI1, AUX1 and two genes of unknown function) is controlled by both CER7 and tasiRNAs.
Measuring Energy Poverty: Is GDP Helpful?

Gross Domestic Product (GDP) has been used to track a country ' s development for decades, but its suitability to measure human well-being, let alone energy poverty, has been contested. This paper will review the available literature on measuring human well-being in general and methods of measuring energy poverty. Problems with GDP and considerations in measuring energy poverty will be discussed. Due to its inability to measure inequalities and lack of comprehensiveness, GDP cannot accurately portray energy poverty. However, its simplicity makes it easily communicable and became a widely-used metric. A balance between comprehensiveness and simplicity is needed in measuring energy poverty.
Use of Botulinum Toxin A in Cerebral Palsy Use of Botulinum Toxin A in Cerebral Palsy

Botulinum toxin A (BTX-A) is widely used worldwide to overcome the significant prob - lem in spastic cerebral palsy (CP). In the past three decades, botulinum toxin serotype A (BTX-A) has been introduced as a selective treatment option for spasticity in children with cerebral palsy. BTX-A is an acetylcholine-blocking agent that causes presynaptic neuromuscular blocking when injected into the muscle. Its action of decreasing or nor - malization of tone prevent the development of contractures and deformities and avoid or postponed surgical intervention particularly when combined with other treatment modalities such as physiotherapy, casting, orthosis, etc. Equinus deformity, scissoring and crouch gait in the lower limbs, and different spastic deformities like pronation of forearm, elbow flexion, wrist flexion, fisting, or abnormal dystonic posture of upper limb deformities were the main indications wherein botulinum toxin injection is needed in spastic cerebral palsy; moreover, its benefit of relieving pain that are associated with muscular hypertonia and palpation of the muscle, particularly the large one, remains the cornerstone for injection of BTX in CP patient for most experts worldwide, but it needs a well of knowledge in anatomy and its landmark. Invasive procedure like electromy - ography (EMG) is more difficult to be applied successfully in children than in adults. is considered a positive phase of muscle function. Therefore, when relaxing the muscle, the patient’s condition might get worse functionally in some instance. So, the first question clinician put in his account before injecting BTX is whether hypertonia is impeding or improving function; therefore, injection is tailored individually by an expert physician. Generally, the adverse side effects of BTX-A are seldom to occur providing that the physician strictly adheres to the dose ranges and reinjection period. The inter-injection period must be at least 12 weeks to avoid antibodies ands. So far, BTX-A is considered to be safe to some extent if used professionally; however, long-term adverse effect particularly with multilevel therapy are still not clear.
The Effect of Catalyst Placement on the Stability of a U-Bend Catalytic Heat-Recirculating Micro-Combustor: A Numerical Investigation

: This study investigates the combined effect of catalyst placement and solid thermal conductivity on the stability of a U-bend catalytic heat-recirculating micro-combustor. The CFD code ANSYS Fluent 2020 R1 was used for two-dimensional simulations of lean premixed propane/air combustion by varying the inlet gas velocity, i.e., the input power. Three conﬁgurations were compared at low (3 W/(m K)) and high (30 W/(m K)) wall thermal conductivity: (A) the conﬁguration in which both inner and outer walls are catalyst coated; (B) only the inner wall is catalyst coated; and (C) only the outer wall is catalyst coated. Numerical results show that, at low thermal conductivity, conﬁguration (B) exhibits the same resistance to extinction as conﬁguration (A), whereas at high thermal conductivity, conﬁgurations (B) and (C) exhibit much lower resistance to blowout than conﬁguration (A). Accordingly, for low-power systems, which typically lose stability via extinction and thus require low-conductive materials, an optimal catalyst placement can be the partial coating of conﬁguration (B). Conversely, for high-power systems, which are prone to blowout and thus require high-conductivity materials, a full coating of both the inner and outer walls is needed to guarantee higher stability. To elucidate these ﬁndings, a detailed analysis of the combustion behavior of the three conﬁgurations is presented.
D1 dopamine receptors modulate ∆ FosB induction in rat striatum following intermittent morphine administration

Induction of the transcription factor ∆ FosB was studied in order to examine neurochemical adaptations produced by repeated opiate administration. The mechanism of this induction was also investigated. The 35-37 kDa isoforms of ∆ FosB, also referred to as the chronic Fras, were measured in the nucleus accumbens, caudate putamen and frontal cortex of male Sprague-Dawley rats following either an acute injection of morphine or an escalating dosing schedule of morphine for 10 days. Heroin was also tested to determine if the findings extend to other opiates. Results from Western blot analysis using an anti-fosB antibody demonstrate that 10-day intermittent escalating dose morphine produced a significant increase in ∆ FosB-immunoreactivity in the nucleus accumbens, caudate putamen and frontal cortex whereas a single injection of morphine had no effect on Fra immunoreactivity. Heroin administered twice daily for 10 days by an intermittent escalating dose schedule also induced ∆ FosB in the caudate putamen, but not in the nucleus accumbens or frontal cortex. Daily pretreatment with the selective D1-like dopamine receptor antagonist, SCH 23390, significantly blocked morphine-induced ∆ FosB induction in the nucleus accumbens and caudate putamen, but not in the frontal cortex. These results demonstrate that morphine-induced ∆ FosB upregulation in the striatum, but not in the frontal cortex, is modulated by D1 dopamine receptors, suggesting that the mechanisms involved in the upregulation of these chronic Fras by morphine is brain region specific.
Financial Viability and Technical Evaluation of Dendritic Cell-Carrying

Cancer immunotherapy attempts to stimulate the immune system to reject and destroy tumor cells. Despite the amount of ongoing intensive research to prevent cancer, tumor cells continue to evade immune responses. Currently, dendritic cell vaccines are in development, in which autologous antigen-loaded dendritic cells are injected back into the patient in order to generate an appropriate immune response. Improving upon this idea, members of the Irvine laboratory are in development of an injectable dendritic cell based formulation that gels in situ around the tumor site. In this way, immune cells (most notably T cells) can be recruited and become activated against specific tumor antigens, and (hopefully) kill tumor cells. Recent studies have shown the potential benefit of incorporation of cytokine interleukin-15 complexed with its soluble receptor interleukin15Ra, which is discussed. Economic considerations are also discussed, including topics such as intellectual property, barriers to entry, initial markets and market drivers, and entry into the current supply chain considerations. A business strategy is outlined and evaluated. Thesis Supervisor: Darrell J. Irvine Title: Eugene Bell Career Development Associate Professor of Tissue Engineering
A Study of Network Security Metrics and Secure Computing

Dependable and secure computing has grabbed the spotlight and has pioneered the fusion between dependability and security since 2000. The field of dependability has progressed to be an internationally active field of research. The objective is to explicate a set of attributes that includes reliability, security, safety, availability, confidentiality, integrity and maintainability. Due to the increasing reliance on computer systems in most societies, the field is of growing importance. It has control over the physical access to the hardware and also provides protection against harm that may come via network access and code injection. Malpractice done by operators, whether intentional, accidental, or due to them being tricked can also be controlled. Also the rapid increase in mobile applications, computers, and wireless networks has modified the characteristics of network security. A series of Internet attack and fraudulent acts on individual network and companies have shown that open computer networks have no immunity from intrusions. The purpose of the paper is to provide review of the existing literature available in the dependable and secure computing domain. The paper also presents an overview and study of the network security metrics with several security threats, security issues, security solutions and currently used methodologies to overcome it.
NDT_A_296451 575..585

1Mood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, ON, Canada; 2Department of Biostatistics and Programming, H. Lundbeck A/S, Valby, Denmark; 3Department of Psychiatry Products, H. Lundbeck A/S, Valby, Denmark Purpose: Anhedonia is a core symptom of major depressive disorder (MDD), which has important functional consequences for the patient. This post hoc analysis investigated the relationship between anhedonia and functioning in patients with MDD treated with vortioxetine. Patients and Methods: We conducted a pooled analysis of all 11 short-term, double-blind, randomized, placebo-controlled studies of vortioxetine (fixed dose, 5–20 mg/day) in patients with MDD which included Montgomery–Åsberg Depression Rating Scale (MADRS) and Sheehan Disability Scale (SDS) assessments. A short-term, randomized, active-controlled trial of flexible-dose treatment with vortioxetine (10–20 mg/day) versus agomelatine (25–50 mg/day) was also analyzed. Mean changes from baseline to study endpoint in MADRS total, MADRS anhedonia subscale, SDS total, and SDS social-functioning scores were analyzed by a mixed model for repeated measures. The relationship between treatment effects on anhedonia and functioning was investigated using path analysis. Results: A total of 4988 patients with MDD were included in the placebo-controlled studies and 495 in the active-comparator study. Significant dose-dependent improvements in overall depressive symptoms, anhedonia, and measures of functioning were seen in vortioxetinetreated patients compared with those who received placebo or agomelatine. Results of the path analysis for the placebo-controlled studies suggested that the effect on functioning was mostly driven by the effect of treatment on MADRS anhedonia factors. Conclusion: Vortioxetine showed significant short-term efficacy against anhedonia in this large population of patients with MDD. In the placebo-controlled studies, improvements in functioning associated with vortioxetine appeared to be mostly driven by the effect of treatment on MADRS anhedonia factors.
Research: A Requirements Search Engine: Progress Report 2

This research addresses three closely related problems. (1) Most current search technology is based on a popularity metric (e.g., PageRank or ExpertRank), but not on the semantic content of the searched document. (2) When building components in a serviceoriented architecture (SOA), developers must investigate whether components that meet certain requirements already exist. (3) There is no easy way for writers of requirements documents to formally specify the meaning and domain of their requirements. Our goal in the research presented here is to address these concerns by designing a search engine that searches over the “meanings" of requirements documents. In this paper, we present the current state of the ReSEARCH project.
Prevalence of modifiable risk factors of tuberculosis and their population attributable fraction in Iran: A cross-sectional study

Background The mycobacterium tuberculosis (Mtb) is necessary for the morbidity of tuberculosis (TB), but it is insufficient. Many risk factors increase the risk of disease among infected people. We aimed to estimate the prevalence of modifiable risk factors of TB and their related population attributable fraction (PAF) in the marginal population of Markazi province in Iran. Design In this cross-sectional study, the prevalence of the modifiable risk factors of TB was estimated. We designed and validated a questionnaire to determine the risk factors. The measures of association for the modifiable risk factors of TB were obtained via the review of published literature. We calculated the PAF for each modifiable risk factor. Results Out of the 1275 calculated sample size, 1146 people participated in this study, and the participation rate was 89.9%. The mean age was 39.26. Out of 1146 participants, 76% did not know anything regarding TB. The highest prevalence was related to the lack of physical activity (58.73%), lack of fish consumption (50.79%), lack of red meat consumption (21.20%), and secondhand smoke (19.02%). The highest PAF was related to secondhand smoke; this value based on the crude relative risk (RR) and crude odds ratio (OR) was 24.54% and 23.44%, respectively. Based on crude hazard ratio (HR) and crude OR, the PAF for smoking was 14.81% and 11.19%, respectively. PAF for lack of BCG vaccination based on the crude OR was 14.79%. Conclusion Based on this study’s results, poor nutrition, secondhand smoke, smoking, lack of BCG vaccination, and diabetes are the main prevalent modifiable risk factors for TB. The highest PAF for TB was related to secondhand smoke, smoking, lack of BCG vaccination, and diabetes.
Comparison of negative pressure wound therapy and moist wound care in patients with diabetic foot ulcers: A protocol for systematic review and meta-analysis of randomized controlled trials

Background: This study conducted a meta-analysis to compare the effectiveness and safety of the negative pressure wound therapy (NPWT) with the moist wound care (MWC) in the treatment of diabetic foot ulcers (DFUs). Methods: The PubMed, EMBASE, and CENTRAL were searched by 2 of the authors, to identify randomized controlled trials comparing the clinical outcomes of patients treated with NPWT versus MWC for DFUs. Meta-analyses were performed for several outcomes, including wound healing results, amputation or resection incidence, and risk of adverse events, utilizing the “meta” package of R language version 4.0. 3. Results: A total of 10 trials (619 patients in NPWT group and 625 in MWC group) and 8 trials were included for the qualitative and quantitative syntheses, respectively. As a result, significantly lower risk of non-closure of the wound (risk ratio [RR] = 0.74, 95% confidence interval [CI]: 0.63–0.87; P = .001), lower average wound area (standard mean difference = −0.80, 95% CI: −1.54 to −0.06; P = .034), more wound area decrease (standard mean difference = 0.81, 95% CI: 0.36–1.26; P = .001), increased appearance rate of granulation tissue (RR = 1.61, 95% CI: 1.07–2.41; P-0.021), and lower risk of amputation or resection (RR = 0.70, 95% CI: 0.50–0.99; P = .045), were demonstrated for the NPWT group when compared to MWC group. However, no statistically significant difference was found for the disappearance rate of wound discharge at 8 weeks, the rate of blood culture positivity, VAS-pain score, and the overall frequency of adverse events between the 2 treatment groups (P = .05). Conclusion: NPWT could accelerate process of the wound healing, and decrease the risk of post-treatment amputation or resection, without any additional frequency of adverse events, when compared with MWC, in patients with DFUs.