Miracle-dz/UniFAR-FTUs huggingface dataset:
A general approach for imputation of non-normal continuous data based on copula transformation

Abstract Dealing with missing data problems for skewed data is a difficult task especially since most of the imputation and data augmentation methodologies assume multivariate normality. The performance of imputation and hence the accuracy of inference on parameters become questionable when the violation of the above assumption occurs. One approach to solve the normality violation is to apply normalizing transformation prior to the imputation phase. However, this approach may introduce new problems such as altering the dependence structure among random variables. We present a general purpose multiple imputation approach based on Copula transformation. The approach is used to effectively transform any continuous multivariate non-normal data to multivariate normal, thereby allowing the imputation using standard normality-based techniques. The method then allows to conveniently back transform the data into original space. Real data sets are used to illustrate the techniques. We then compare the performance of our Copula-based method with other traditional normality-based multiple imputation approaches through extensive simulated and real non-normal multivariate datasets. We demonstrate that this method significantly mitigates the problem and hence the practice of making the blind assumption of multivariate normality for non-normal multivariate data under the assumption that data are missing at different mechanisms.
Internalized Sexual Stigma among Lesbian, Gay, and Bisexual Individuals in Taiwan: Its Related Factors and Association with Mental Health Problems

Internalized sexual stigma (ISS) is one of the major issues that can compromise the health of sexual minority populations. This quantitative study aimed to examine: (1) the relationships of individual factors (gender, age, education level, sexual orientation, and age of identification of sexual orientation) and perceived family support with ISS; and (2) the associations of ISS with mood problems and the moderating effects of gender on the associations among Taiwanese young adult lesbian, gay, and bisexual (LGB) individuals. In total, 500 male and 500 female young adult LGB individuals aged between 20 and 30 years participated in this study. The experience of ISS, individual (e.g., gender, age, education level, sexual orientation, and age of identification of sexual orientation) and environmental factors (perceived family), mood problems (e.g., anxiety and depression) were collected. The individual and environmental factors related to ISS and the associations of ISS with mood problems were examined using multivariate linear regression analysis. The results indicated that gender, sexual orientation, age of identification of sexual orientation, and perceived family support were significantly associated with all or some dimensions of ISS in LGB individuals. Various dimensions of ISS had different relationships with anxiety and depression. Gender had moderating effects on the association between the identity dimension of ISS and sexual orientation as well as between the social discomfort dimension of ISS and anxiety. Various dimensions of ISS among LGB individuals should be routinely assessed by mental health service units. Intervention programs should be provided for LGB individuals, especially those with factors related to ISS.
Intraseasonal variation of the northeast Asian anomalous anticyclone and its impacts on air pollution in the North China Plain in early winter

Abstract. The canonical view of the northeast Asian anomalous anticyclone (NAAA) is a crucial factor for determining poor air quality in the North China Plain (NCP) on the interannual timescale. However, there is considerable intraseasonal variability in the NAAA in early winter (November to January), and the corresponding mechanism of its impacts on air pollution in the NCP is not well understood. Here, we find that the intraseasonal NAAA usually establishes quickly on day −3 with a life span of eight days, and its evolution is closely tied to the Rossby wave from upstream (i.e., the North Atlantic). Moreover, we find that the NAAA with a westward tilt might be mainly related to the wavenumbers 3−4. Further results reveal that under this background, the probability of regional air pollution for at least three days in the NCP is as high as 69 % (80 % at least two days) in NDJ period 2000−2021. In particular, air quality in the NCP tends to deteriorate on day 2 prior to the peak day of the NAAA and reaches a peak on day −1 with a life cycle of four days. In the course of air pollution, a shallower atmospheric boundary layer and stronger surface southerly wind anomaly associated with the NAAA in the NCP appear 1 day earlier than poor air quality, which provides dynamic and thermal conditions for the accumulation of pollutants and finally occurrence of the air pollution on the following day. Furthermore, we show that the stagnant air leading to poor air quality is determined by the special structure of temperature in the vertical direction of the NAAA, while weak ventilation conditions might be related to a rapid buildup of the NAAA. The present results quantify the impact of the NAAA on air pollution in the NCP on the intraseasonal timescale.
Physiological Responses to Combat Sports in Metabolic Diseases: A Systematic Review

The aim of this systematic review was to investigate how individuals with metabolic diseases respond to combat sports and if they are feasible, safe, and applicable. A systematic literature search was conducted in PubMed, from inception until 22 January 2021. Studies were included if combat sport exercise sessions were clearly defined and participants had the following types of metabolic disease: type 1 or 2 diabetes mellitus, metabolic syndrome, overweight, and obesity. Eleven studies, involving 472 participants of all age groups with type 1 diabetes mellitus, metabolic syndrome, overweight, or obesity were included in this systematic review. No studies involving combat sports and individuals with type 2 diabetes were found. Combat sports showed improved HbA1c levels over time in individuals with type 1 diabetes mellitus, which was not significantly different compared to the control group (p = 0.57). During the follow-up period, glycaemic variability decreased in those actively participating in combat sports. Fat-mass was higher in athletes performing combat sports with metabolic syndrome, compared to athletes without an increased cardiometabolic risk. In overweight/obese adolescents, combat sports showed improved parameters of physical fitness, cardio autonomic control, strength, and body composition compared to control groups. In all studies included in this systematic review, no adverse event associated with combat sports was reported. In conclusion, combat sports are safe and feasible in individuals with diabetes and/or obesity. For individuals with type 2 diabetes mellitus, no recommendations can be made, due to the lack of evidence in this cohort. Future studies investigating combat sports and metabolic diseases should aim for a structured exercise regimen and acknowledge the experience of the participants prior to starting an exercise intervention involving combat sports.
Evaluation of the Physicochemical and Functional Properties of Aquasoya (Glycine max Merr.) Powder for Vegan Muffin Preparation

Recent concerns on health and sustainability have prompted the use of legumes as a source of plant-based proteins, resulting in the application of their cooking water as a substitute for egg whites. In this study, the cooking water of yellow soybeans was powdered, and, subsequently, the nutritional and functional characteristics of powders from yellow soybeans (YSP), chickpeas (CHP), and egg whites (EWP) were compared. The main components of these powders (total polyphenol, total carbohydrate, and protein), along with their hydration properties (hygroscopicity, water solubility index, and water/oil holding capacities), and emulsifying and foaming properties, were identified. The muffins prepared with YSP, CHP, and EWP were analyzed to determine their basic characteristics, such as volume, baking loss, and sensory attributes. The results of the powder analyses indicated that YSP was significantly superior to CHP and EWP, particularly in terms of holding capacities, and emulsion and foam stabilities. The sensory evaluation results showed that there was no statistically significant difference in overall acceptance among the muffin samples. Therefore, YSP can be used as an alternative to CHP or EWP, and applied as a novel ingredient in various vegan products.
A needs analysis study of English materials for Indonesian domestic workers

International migration is basically a phenomenon which represents family or individual efforts to maintain their existence, and desire to improve their quality of life (Nagayama, 1995). Today, this phenomenon is becoming increasingly important in Indonesia (Hugo, 1995; Spaan, 1994; Adi, 1995). International migration flows in Indonesia will continue to increase in the future due to the limited job opportunity, the increasing average level of education in Indonesia, proliferation of mass media, easy and cheap access to overseas countries, and developments in national and global transport systems. This study deals with English for Specific Purposes (ESP) which is designed to improve the quality Indonesian Domestic Workers particularly Female Workers who work overseas, especially Malaysia. ESP approach, not a product, which means that we do not teach special form of a language but it can be cal of a particular context of use. It is meant that the learners would likely to meet in the target situation (Hutchinson and Waters, 1986). ESP is not just a matter of science works and grammar for scientists, etc. But it is linked with performance and competence. It means that what people actually do with language and the range of knowledge and ability, which enable them to do it. ESP is not different from any other language teaching; that is, based on the principle of effective and efficient learning. ESP course are providing the learners with competence of using English for specific fields of knowledge at the advantage level. It also concerns the design curriculum, using approaches, methods and techniques in advanced ESP and develops material for the syllabus: type of authentic scientific writing, grammatical features, vocabulary building and principles in the teaching and learning of ESP. This study identifies the language skills required by the Indonesian workers to be able to work teaching materials to fulfill the workers needs. The information gathering on the needs to the Indonesian workers is limited to the female workers who would like to work overseas in this case Malaysia, do ks such as cleaning and polish lug floors, washing, ironing, buying food and other domestic necessities, preparing food and serving meals. This study is expected to give some relevant contributions to the educationists who are willing to design materials of their own; the Indonesian community to be exist elsewhere-Malaysia; the Indonesian domestic workers to improve their quality so that they can move more freely in the international society.
Development of an Electrochemical Sensor Using a Modified Carbon Paste Electrode with Silver Nanoparticles Capped with Saffron for Monitoring Mephedrone

Mephedrone, also known as 4-methylmethcathinone, is growing into a prominent recreational drug for young people. When it came to detecting mephedrone, limited efforts were made using electrochemical sensors. As a result, this application depicts the fabrication of a new, sensitive, selective, and economical electrochemical sensor capable of detecting mephedrone by using silver nanoparticles capped with saffron produced through electropolymerization to modify carbon paste electrodes (CPEs). Silver nanoparticles (AgNPs) were capped with saffron (AgNPs@Sa) using a green method. AgNPs@Sa were studied using electron scanning microscopy (SEM) and UV-vis spectroscopy. The sensor was evaluated under the optimum condition to determine its analytical features. The results showed that this procedure had a wide linear range, low detection limit and sufficient reproducibility. Furthermore, the sensor posed sufficient stability. Moreover, it was applied in the determination of mephedrone in urine samples, showing the potential applicability of this electrochemical sensor in real sample analysis.
Simulative Investigation of Different DLD Microsystem Designs with Increased Reynolds Numbers Using a Two-Way Coupled IBM-CFD/6-DOF Approach

Deterministic lateral displacement (DLD) microsystems are suitable for the size fractionation of particle suspensions in the size range of 0.1 to 10 µm. To be able to fractionate real particles beyond a laboratory scale, these systems have to be designed for higher throughputs. High flow resistances and increasing the clogging of the systems impose substantial challenges for industrial operation. Simulative parameter studies are suitable for improving the design of the systems; for example, the position and shape of the posts. A high-resolution, two-way coupled 6-DOF CFD-DEM approach was used to study the flow and particle behavior of different post shapes (circular and triangular) and post sizes at different Reynolds numbers. The results were compared with the classical first streamline width theory. It was shown that the streamline theory does not account for all effects responsible for the separation. Furthermore, a shift in the critical particle diameter to smaller values could be obtained when increasing the Reynolds number and also when using triangular posts with reduced post sizes compared to the post spacing. These findings can help to improve the efficiency of the systems as the post spacing could be extended, thus reducing the flow resistance and the probability of clogging.
T1121G Point Mutation in the Mitochondrial Gene COX1 Suppresses a Null Mutation in ATP23 Required for the Assembly of Yeast Mitochondrial ATP Synthase

Nuclear-encoded Atp23 was previously shown to have dual functions, including processing the yeast Atp6 precursor and assisting the assembly of yeast mitochondrial ATP synthase. However, it remains unknown whether there are genes functionally complementary to ATP23 to rescue atp23 null mutant. In the present paper, we screen and characterize three revertants of atp23 null mutant and reveal a T1121G point mutation in the mitochondrial gene COX1 coding sequence, which leads to Val374Gly mutation in Cox1, the suppressor in the revertants. This was verified further by the partial restoration of mitochondrial ATP synthase assembly in atp23 null mutant transformed with exogenous hybrid COX1 T1121G mutant plasmid. The predicted tertiary structure of the Cox1 p.Val374Gly mutation showed no obvious difference from wild-type Cox1. By further chase labeling with isotope [35S]-methionine, we found that the stability of Atp6 of ATP synthase increased in the revertants compared with the atp23 null mutant. Taking all the data together, we revealed that the T1121G point mutation of mitochondrial gene COX1 could partially restore the unassembly of mitochondrial ATP synthase in atp23 null mutant by increasing the stability of Atp6. Therefore, this study uncovers a gene that is partially functionally complementary to ATP23 to rescue ATP23 deficiency, broadening our understanding of the relationship between yeast the cytochrome c oxidase complex and mitochondrial ATP synthase complex.
Bayesian forecasting of U.S. recessions using new Keynesian models with heterogeneous expectations

ABSTRACT In this paper, the Bayesian point forecasting performances of small-scale and medium-scale New Keynesian models, each augmented to include heterogeneous expectations via the Euler equation adaptive learning method, are compared to their homogeneous expectations counterparts during the three most recent U.S. recessions. Forecasting performance is assessed based on root mean squared error. Results show that, in general, the models with heterogeneous expectations forecast recessions better than their homogeneous expectations counterparts.
Sulfur and Nitrogen Depositions in BULGARIA—Model Results and Observations

Atmospheric deposition processes are of primary importance for human health, forests, agricultural lands, aquatic bodies, and ecosystems. South-East Europe is still characterized by numerous hot spots of elevated sulfur deposition, despite the reduction in European emission sources. The purpose of this study is to discuss the results from two chemical transport models and observations for wet and dry depositions of sulfur (S), reduced nitrogen (RDN) and oxidized nitrogen (OXN) in Bulgaria in 2016–2017. The spatial distribution and the domain main deposition values by EMEP MSC-W (model of the MSC-W Centre of the Co-operative Programme for Monitoring and Evaluation of the Long-range Transmissions of Air Pollutants in Europe) and BgCWFS (Bulgarian Chemical Weather Forecast System) demonstrated S wet depositions to be higher than N depositions, and identified a rural area in south-east Bulgaria as a possible hot-spot. The chemical analysis of deposition samples at three sites showed a prevalence of sulfate in the western part of the country, and prevalence of Cl and Na at a coastal site. The comparison between modeled and observed depositions demonstrated that both models captured the prevalence of S wet depositions at all sites. Better performance of BgCWFS with an average absolute value of the normalized mean bias of 16% was found.
On-Line Foreign Object Detection Using Double DD Coils in an Inductive Wireless Power Transfer System

This paper proposes an on-line method for foreign object detection in a double DD coil system. The foreign object is detected by real-time measurement of the mutual inductance between the transfer pads. Measurement of the mutual inductance between coils can be performed at the start, during initialisation, or during the wireless power transfer. The coils in the double DD coil structure can be used separately; one coil can be used for power transfer and the other can be used for the mutual inductance measurement. The mutual inductance measurement is based on the voltage measurement across the open circuit receiver coil. The measured value of mutual inductance between the transmitter and the receiver pad can be used in a control algorithm and in a foreign object detection algorithm. Additionally, a 2DDq coil structure can be used as a replacement for the double DD coil structure, which increases the power transfer density. The DD coils in the double DD coil structure can also be driven using two phase-shifted voltages, which enables better location and detection of foreign objects. The method also helps to differentiate the mutual inductance change due to the distance change from the mutual inductance change due to the presence of a foreign object.
Dependence of click-SELEX performance on the nature and average number of modified nucleotides

The click-SELEX procedure enables the identification of nucleobase-modified aptamers in which chemical entities are introduced by a copper(i)-catalysed alkyne-azide ‘click’ reaction. Here we report on the impact of modified nucleobases on PCR conditions and the average amount of modified nucleobases on click-SELEX performance. We demonstrate click-SELEX being strongly dependent on which and on how many modifications are used. However, when using C3-GFP the number of modifications did not impact the overall success of the selection procedure.
Governance, FDI and tourism in top 10 tourist destinations in Africa

Abstract The study examines the impact of foreign direct investment (FDI) and governance quality on tourism demand in selected 10 African countries. We further examine the role of governance quality in the FDI-tourism demand nexus. The study employs panel data of 10 most preferred tourist countries in Africa over a period of 1995–2019. These data are sourced from World Bank Development Indicators and World Bank Governance Indicators’ Database. Panel unit root tests, Johanson-Fisher Cointegration Test and panel cointegrating regression are employed. The results reveal that there is a long run relationship among the variables and FDI has a positive and significant impact on tourism. Similarly, the quality of governance improves the level of tourism arrivals. In addition, quality governance plays a significant role in the tourism sector of the selected countries in Africa. The policy implications are as well discussed.
Diverse Secondary Metabolites from the Coral-Derived Fungus Aspergillus hiratsukae SCSIO 5Bn1003

Three new metabolites, including a cyclic tetrapeptide asperhiratide (1), an ecdysteroid derivative asperhiratine (2), and a sesquiterpene lactone asperhiratone (3), were isolated and identified from the soft coral-derived fungus Aspergillus hiratsukae SCSIO 5Bn1003, together with 10 known compounds. Their structures were elucidated via spectroscopic analysis, X-ray diffraction analysis, and electronic circular dichroism calculations. In addition, the absolute configuration of 1 was determined by Marfey’s technique and an analysis of the acid hydrolysates using a chiral phase HPLC column. Among all the compounds, 6 and 8 showed medium cytotoxic activities against four tumor cell lines (SF-268, HepG-2, MCF-7, and A549), with IC50 values ranging from 31.03 ± 3.04 to 50.25 ± 0.54 µM. Meanwhile, they strongly inhibited α-glucosidase activities, with IC50 values of 35.73 ± 3.94 and 22.00 ± 2.45 µM, which were close to and even stronger than the positive control acarbose (IC50 = 32.92 ± 1.03 µM). Compounds 6–8 showed significant antibacterial activities against Bacillus subtilis, with MIC values of 10.26 ± 0.76 µM, 17.00 ± 1.25 µM, and 5.30 ± 0.29 µM, respectively. Compounds 9 and 12 exhibited potent radical scavenging activities against DPPH, with IC50 values of 12.23 ± 0.78 µM and 7.38 ± 1.16 µM. In addition, asperhiratide (1) was evaluated for anti-angiogenic activities in the in vivo zebrafish model, which showed a weak inhibitory effect on intersegmental vessel (ISV) formation.
Using a leverage points perspective to compare social-ecological systems: a case study on rural landscapes

ABSTRACT A leverage points perspective recognises different levels of systemic depth, ranging from the relatively shallow levels of parameters and feedbacks to the deeper levels of system design and intent. Analysing a given social-ecological system for its characteristics across these four levels of systemic depth provides a useful diagnostic to better understand sustainability problems, and can complement other types of cause-and-effect systems modelling. Moreover, the structured comparison of multiple systems can highlight whether sustainability challenges in different systems have a similar origin (e.g. similar feedbacks or similar design). We used a leverage points perspective to systematically compare findings from three in-depth social-ecological case studies, which investigated rural landscapes in southeastern Australia, central Romania, and southwestern Ethiopia. Inductive coding of key findings documented in over 60 empirical publications was used to generate synthesis statements of key findings in the three case studies. Despite major socioeconomic and ecological differences, many synthesis statements applied to all three case studies. Major sustainability problems occurred at the design and intent levels. For example, at the intent level, all three rural landscapes were driven by goals and paradigms that mirrored a productivist green revolution discourse. Our paper thus highlights that there are underlying challenges for rural sustainability across the world, which appear to apply similarly across strongly contrasting socioeconomic contexts. Sustainability interventions should be mindful of such deep similarities in system characteristics. We conclude that a leverage points perspective could be used to compare many other types of social-ecological systems around the world.