Miracle-dz/UniFAR-FTUs huggingface dataset:
Vital sign predictors of severe influenza among children in an emergent care setting

Background Decisions regarding the evaluation of children with influenza infection rely on the likelihood of severe disease. The role of early vital signs as predictors of severe influenza infection in children is not well known. Our objectives were to determine the value of vital signs in predicting hospitalization/recurrent emergency department (ED) visits due to influenza infection in children. Methods We conducted a prospective study of children aged 6 months to 8 years of age with influenza like illness evaluated at an ED/UC from 2016–2018. All children underwent influenza testing by PCR. We collected heart rate, respiratory rate and temperature, and converted heart rate (HR) and respiratory rate (RR) to z-scores by age. HR z scores were further adjusted for temperature. Our primary outcome was hospitalization/recurrent ED visits within 72 hours. Vital sign predictors with p< 0.2 and other clinical covariates were entered into a multivariable logistic regression model to determine odds ratios (OR) and 95% CI; model performance was assessed using the Brier score and discriminative ability with the C statistic. Results Among 1478 children, 411 (27.8%) were positive for influenza, of which 42 (10.2%) were hospitalized or had a recurrent ED visit. In multivariable analyses, adjusting for age, high-risk medical condition and school/daycare attendance, higher adjusted respiratory rate (OR 2.09, 95%CI 1.21–3.61, p = 0.0085) was a significant predictor of influenza hospitalization/recurrent ED visits. Conclusions Higher respiratory rate adjusted for age was the most useful vital sign predictor of severity among young children with PCR-confirmed influenza.
Origins, evolution, and physiological implications of de novo genes in yeast

De novo gene birth is the process by which new genes emerge in sequences that were previously noncoding. Over the past decade, researchers have taken advantage of the power of yeast as a model and a tool to study the evolutionary mechanisms and physiological implications of de novo gene birth. We summarize the mechanisms that have been proposed to explicate how noncoding sequences can become protein‐coding genes, highlighting the discovery of pervasive translation of the yeast transcriptome and its presumed impact on evolutionary innovation. We summarize current best practices for the identification and characterization of de novo genes. Crucially, we explain that the field is still in its nascency, with the physiological roles of most young yeast de novo genes identified thus far still utterly unknown. We hope this review inspires researchers to investigate the true contribution of de novo gene birth to cellular physiology and phenotypic diversity across yeast strains and species.
Application of the Force-velocity-power Concept to the 3-min all-out Running Test

Abstract Force-velocity-power (FVP) profiling offers insights related to key factors that may enhance or hinder sprinting performances. Whether the same FVP principles could be applied to the sprinting portion of the 3-minute all-out test for running (3MT) has not been previously investigated. Twenty moderately trained participants volunteered for the study (age: 24.75 ± 3.58 yrs; height: 1.69±0.11 m; mass: 73.74±12.26 kg). After familiarization of all testing procedures, participants completed: (i) a 40-m all-out sprint test, and (ii) a 3MT. Theoretical maximal force and power, but not velocity, were significantly higher for the 40-m sprint test. Most FVP variables from the two tests were weakly to moderately correlated, with the exception of maximal velocity. Finally, maximal velocity and relative peak power were predictive of D’, explaining approximately 51% of the variance in D’. Although similar maximal velocities are attained during both the 40-m sprint and the 3MT, the underlying mechanisms are markedly different. The FVP parameters obtained from either test are likely not interchangeable but do provide valuable insights regarding the potential mechanisms by which D’ may be improved.
Quantitative signal quality assessment for large-scale continuous scalp electroencephalography from a big data perspective

Objective. Despite electroencephalography (EEG) being a widely used neuroimaging technique with an excellent temporal resolution, in practice, the signals are heavily contaminated by artifacts masking responses of interest in an experiment. It is thus essential to guarantee a prompt and effective detection of artifacts that provides quantitative quality assessment (QA) on raw EEG data. This type of pipeline is crucial for large-scale EEG studies. However, current EEG QA studies are still limited. Approach. In this study, combined from a big data perspective, we therefore describe a quantitative signal quality assessment pipeline, a stable and general threshold-based QA pipeline that automatically integrates artifact detection and new QA measures to assess continuous resting-state raw EEG data. One simulation dataset and two resting-state EEG datasets from 42 healthy subjects and 983 clinical patients were utilized to calibrate the QA pipeline. Main Results. The results demonstrate that (1) the QA indices selected are sensitive: they almost strictly and linearly decrease as the noise level increases; (2) stable, replicable QA thresholds are valid for other experimental and clinical EEG datasets; and (3) use of the QA pipeline on these datasets reveals that high-frequency noises are the most common noises in EEG practice. The QA pipeline is also deployed in the WeBrain cloud platform (https://webrain.uestc.edu.cn/, the Chinese EEG Brain Consortium portal). Significance. These findings suggest that the proposed QA pipeline may be a stable and promising approach for quantitative EEG signal quality assessment in large-scale EEG studies.
Research on Automatic Generation Control with Wind Power Participation Based on Predictive Optimal 2-Degree-of-Freedom PID Strategy for Multi-area Interconnected Power System

High penetration of wind power in the modern power system renders traditional automatic generation control (AGC) methods more challenging, due to the uncertainty of the external environment, less reserve power, and small inertia constant of the power system. An improved AGC method named predictive optimal 2-degree-of-freedom proportion integral differential (PO-2-DOF-PID) is proposed in this paper, which wind farm will participate in the load frequency control process. Firstly, the mathematical model of the AGC system of multi-area power grid with penetration of wind power is built. Then, predictive optimal 2-degree-of-freedom PID controller is presented to improve the system robustness considering system uncertainties. The objective function is designed based on the wind speed and whether wind farm takes part in AGC or not. The controller solves the optimization problem through the predictive theory while taking into account given constraints. In order to obtain the predictive sequence of output of the whole system, the characteristic of the 2-DOF-PID controller is integrated in the system model. A three interconnected power system is introduced as an example to test the feasibility and effectiveness of the proposed method. When considering the penetration of wind power, two cases of high wind speed and low wind speed are analyzed. The simulation results indicate that the proposed method can effectively deal with the negative influence caused by wind power when wind power participates in AGC.
Who’s Helping Whom? Examination of Care Arrangements for Racially and Ethnically Diverse People Living With Dementia in the Community

Objective: To address notions around care arrangements for Black and Hispanic people living with dementia (PLwD), the study examined if racial and ethnic differences exist for community-dwelling PLwD. Methods: Using cross-sectional data from the 2015 National Health and Aging Trends Study, we used Pearson’s chi-square and mean comparison to examine differences among a sample of n = 863 community-dwelling White, Black, and Hispanic older PLwD. Results: Black PLwD were less likely than White PLwD to use paid help (26.8% vs. 32.6%), but Hispanic PLwD were most likely to use paid help (46.2%, p < 0.05). Black and Hispanic older adults were more often receiving help from a child (65.8% and 72.2%, respectively; p = 0.01) or other family member (40.3% and 31.0%, respectively; p < 0.01). Discussion: Our findings highlight the important role of familial support in care provision for Black and Hispanic communities. Caregiving supports should be intentional in centering services on the family, not a sole caregiver.
Exploring the mechanism of Buyang Huanwu decoction in the treatment of lumbar disc herniation based on network pharmacology and molecular docking

Buyang Huanwu decoction (BYHWD), as one of the traditional Chinese medicine formulas, is widely used in the clinical treatment of lumbar disc herniation (LDH) with curative effect. It has the characteristics of multi-component, multi-target, and mutual synergy, but the mechanism of action is often unclear. It needs some research to explore the molecular mechanism of BYHWD in the treatment of LDH based on network pharmacology and molecular docking. Screen the active compounds of BYHWD and predict drug-related gene/protein targets, which could determine the specific target of BYHWD in the treatment of LDH. Construct the “Drugs-Compounds-Targets” network and search for the core targets. Use Gene Ontology functional enrichment analysis, Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis, and molecular docking verification to explore the possible molecular mechanism. Eighty-two effective compounds and 666 targets of BYHWD, 187 targets for LDH treatment, and 20 core candidate targets were excavated. A total of 3414 entries were identified by Gene Ontology enrichment analysis, 173 related signal pathways were identified by Kyoto Encyclopedia of Genes and Genomes enrichment analysis, and 5 core compounds were identified by molecular docking, which had a good affinity with core genes STAT3, JUN, AKT1, MAPK1, RELA, and PIK3CA. BYHWD may play the role of analgesic and improving function by synergistic anti-inflammatory and analgesic compounds, regulating cell metabolic differentiation, regulating immunity, and anticoagulation. BYHWD in the treatment of LDH may play a role in analgesia and improve function through multiple signaling pathways, including PI3K-Akt, mitogen-activated protein kinase, tumor necrosis factor, and interleukin-17. The PI3K-Akt signaling may be one of the key mechanisms.
Reflections on fifteen years of service-learning projects in Thailand

Worcester Polytechnic Institute (WPI) provides international experiences for over 50% of its engineering students, more than any other US-based university. As part of its international offerings, WPI has since 1989 been sending mixed teams of engineering, science, and management students to Bangkok to complete 8-week interdisciplinary projects. These projects connect science or technology to social issues and human need, and have been sponsored by Thai nonprofit organizations, government agencies, and universities, as well as by international organizations. The students are accompanied by WPI faculty members who serve as residential project advisors and work closely with the student teams.
Proper group actions in complex geometry

Proper group actions are ubiquitous in mathematics and have many of the attractive features of actions of compact groups. In this survey, we discuss proper actions of Lie groups on smooth manifolds. If the group dimension is sufficiently high, all proper effective actions can be explicitly determined, and our principal goal is to provide a comprehensive exposition of known classification results in the complex setting. They include a complete description of Kobayashi-hyperbolic manifolds with high-dimensional automorphism group, which is a case of special interest.
Cryptotanshinone alleviates myocardial ischemia and reperfusion injury in rats to mitigate ER stress-dependent apoptosis by modulating the JAK1/STAT3 axis.

OBJECTIVE Myocardial ischemia is the stoppage or insufficiency of blood flow to the myocardium, depriving cells of oxygen supply which leads to their apoptosis or death. Currently, the management of patients has improved, making it possible to reduce myocardial infarction injury with new strategies of reperfusion and pharmacologic treatment. METHODS A rat model of myocardial ischemia and reperfusion injury (MIRI) was created and subjected to cryptotanshinone (CRY) with or without JAK1 inhibitor filgotinib (FILGO) treatment. H&E staining was used for histopathologic evaluation of heart injury, and TTC staining was employed for evaluation of the infarct size. Western blotting and immunofluorescence were used to measure the protein expression and qRT-PCR for determining mRNA expression. RESULTS CRY significantly reduced the area of the infarct, the number of apoptotic cells, and the concentrations of lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB) induced by ischemia/reperfusion (I/R). Subsequent analysis showed that CRY repressed the expression of caspase-12, CHOP, and GRP78, but enhanced the phosphorylation of JAK and STAT3. However, FILGO treatment markedly abolished the beneficial effect of CRY pretreatment on cardiomyocyte damage, apoptosis, cardiac function, and inhibition of endoplasmic reticulum stress (ERS)-dependent apoptosis marker proteins. CONCLUSION CRY may alleviate MIRI by inhibiting ERS-dependent apoptosis by activating the JAK1/STAT3 signaling pathway.
Total fecal IgA levels increase and natural IgM antibodies decrease after gastric bypass surgery

Obesity is associated with low‐grade inflammation and increased systemic oxidative stress. Roux‐en‐Y gastric bypass (RYGB) surgery is known to ameliorate the obesity‐induced metabolic dysfunctions. We aimed to study the levels of natural antibodies in feces, before and 6 months after RYGB surgery in obese individuals with and without type 2 diabetes (T2D). Sixteen individuals with T2D and 14 non‐diabetic (ND) individuals were operated. Total IgA, IgG and IgM antibody levels and specific antibodies to oxidized low‐density lipoprotein (oxLDL), malondialdehyde‐acetaldehyde adducts (MAA adducts), Porphyromonas gingivalis gingipain A hemagglutinin domain (Rgp44) and phosphocholine (PCho) were measured using chemiluminescence immunoassay. Total fecal IgA was elevated, while total IgM and IgG were not affected by the surgery. Fecal natural IgM specific to oxLDL decreased significantly in both T2D and ND individuals, while fecal IgM to Rgp44 and PCho decreased significantly in T2D individuals. A decrease in IgG to MAA‐LDL, Rgp44 and PCho was detected. RYGB surgery increases the levels of total fecal IgA and decreases fecal natural IgG and IgM antibodies specific to oxLDL. Natural antibodies and IgA are important in maintaining the normal gut homeostasis and first‐line defense against microbes, and their production is markedly altered with RYGB surgery.
A wideband printed slot antenna with harmonic suppression

A wideband slot antenna with harmonic suppression is proposed to utilize the environment microwave energy. The antenna element is a printed narrow slot with an offset microstrip‐feed line to widen the operating band by generating the double resonance of similar frequencies. By adding a rectangular notch in the middle of slot element and grounding the microstrip terminal, its second‐order and third‐order harmonics are effectively suppressed. The experimental results of the prototype antenna show that the fractional bandwidth of its fundamental mode can reach 37.4%, while the antenna efficiencies of the second and third harmonics both are less than 23%. In the operating band the prototype antenna has the approximately omnidirectional radiation characteristic. This antenna structure also provides relaxed fabrication tolerances.
Osteoporotic hip fracture—Comorbidities and factors associated with in-hospital mortality in the elderly: A nine-year cohort study in Brazil

Introduction The aim of the study was to identify factors associated with the causes of in-hospital morbidity and mortality in an elderly Brazilian population due to osteoporotic hip fractures. Method Retrospective cohort study involving a population over 60 years of age admitted to hospital due to osteoporotic hip fractures and followed up from hospitalization to outcome (discharge or mortality) from 2010 to 2018, in a public hospital in Brasília, the capital of Brazil. Multivariate analysis was performed using the Poisson regression model with a robust variance, observing the hierarchical model proposed and the receiver operating characteristic (ROC) curve to obtain the cutoff point for mortality incidence in relation the total length of hospital stay. Significance level was set as p < 0.05. The analyses were conducted using the SAS 9.4 software. Result The mean hospital mortality rate among the 402 patients involved was 18.4%, and the associations made with the outcome mortality were per relevance: respiratory infection, age over 90 years, high preoperative cardiovascular risk, chronic obstructive pulmonary disease (COPD) as comorbidity, serum hemoglobin level ≤ 10 and other infections. Mortality also showed association with longer total length of hospital stay, as well as with prolonged postoperative period. Conclusion Hip fractures in the elderly due to osteoporosis indicate a relationship between the sicker profile of the aging elderly population and the prevalence of chronic diseases strongly associated with in-hospital infections, contributing to increased mortality. There were fewer early interventions, and mortality was also associated with prolonged postoperative period. The aim of this study was not to compare independent variables with each other, but suggests the relationship between the presence of comorbidities, which predisposes to the development of infections, directly linked to mortality.
Second Harmonic Generation in Subdiffractive Two-Dimensional Photonic Crystals

The PhD thesis is devoted to the study of second harmonic generation of narrow beams in photonic crystals. The basic idea is that if both frequencies, the fundamental and second harmonics are in the region of self-collimation, then the second harmonics of narrow beams can be very efficient. The beams do not spread diffractively during propagation and interaction. The phase matching is ensured for all components of the interacting beams. This allows to enhance the nonlinear interaction efficiency several times. The thesis rewises the theory of self-collimation of narrow beams in photonic crystals, and presents the theory of second harmonics in photonic crystals. Calculations in photonic crystals of different configurations are presented, and the recommendations to experimental realisations are given.
Discrimination of Japanese fricatives and affricates by production boundaries in time and spectral domains: A case study of a female native speaker

Acoustic features of fricatives (/s/ and /C/) and affricates (/¶/ and /tC/) spoken by a female native speaker of Japanese were investigated. Discriminant analysis in the time domain revealed that fricatives (/s/ and /C/) and affricates (/¶/ and /tC/) are well separated at a discriminant ratio of 98.0% (n 1⁄4 508) when using the variables of the rise duration and the sum of steady and decay durations of the consonants’ intensity envelope. Discriminant analysis in the spectral domain revealed that alveolar consonants (/s/ and /¶/) and alveolo-palatal consonants (/C/ and /tC/) are well separated at a discriminant ratio of 99.2% (n 1⁄4 508) when using the variable of the mean intensity of one-thirdoctave bandpass filter with a center frequency of 3,150 Hz. In addition, the four consonants were correctly identified at an accuracy rate of 97.2% (n 1⁄4 508) when using a combination of production boundaries obtained in the above two discriminant analyses. Results suggest that the acoustic features of the four consonants can be represented by the timeand spectral-domain variables described above.
The utility of near infrared autofluorescence imaging for detecting small bowel carcinoid tumors in comparison to DOTATATE PET: A pilot study

Small bowel carcinoid (SBC) primary tumors can be multifocal in 40%–55% of patients and challenging to detect. Near infrared autofluorescence (NIRAF) is used for detection of parathyroid glands. It is unknown if this technology can be used to identify SBCs and how it would compare with current imaging modalities.
The role of endoplasmic reticulum stress in the regulation of long noncoding RNAs in cancer

Cancer cells must overcome a variety of external and internal stresses to survive and proliferate. These unfavorable conditions include the accumulation of mutations, nutrient deficiency, oxidative stress, and hypoxia. These stresses can cause aggregation of misfolded proteins inside the endoplasmic reticulum. Under these conditions, the cell undergoes endoplasmic reticulum stress (ER‐stress), and consequently initiates the unfolded protein response (UPR). Activation of the UPR triggers transcription factors and regulatory factors, including long noncoding RNAs (lncRNAs), which control the gene expression profile to maintain cellular stability and hemostasis. Recent investigations have shown that cancer cells can ensure their survival under adverse conditions by the UPR affecting the expression of lncRNAs. Therefore, understanding the relationship between lncRNA expression and ER stress could open new avenues, and suggest potential therapies to treat various types of cancer.
COVID-19 vaccine acceptance among healthcare workers in China: A systematic review and meta-analysis

Background Since the successful development of Coronavirus Disease (COVID-19) vaccine, COVID-19 vaccination has been actively advocated all over the world. As the key population for COVID-19 vaccination, the acceptance of Healthcare Workers (HCWs) is not only related to their risk of contracting COVID-19 infection at work, but also affects the decision of the general population on COVID-19 vaccination. Currently, a series of observational studies have been conducted on the acceptance of COVID-19 vaccines among HCWs in China, but there are presently no all-inclusive reviews. Therefore, this paper reviewed to identify a reliable estimate of acceptance rate of COVID-19 vaccine among HCWs in China. Methods We conducted a search on PubMed, EMbase, The Cochrane Library, Web of Science, CNKI (Chinese National Knowledge Infrastructure), Wanfang Database, CBM (Chinese Biomedical Literature Database) and VIP database (Chinese Scientific Journal Database) from January 2020 to June 2022. The quality of included articles was estimated using the Newcastle-Ottawa Quality Assessment tool suitable for cross-sectional studies and STATA 16 was used for analysis, A random-effects model was used to calculate acceptance rate for COVID-19 vaccine, as well as subgroup analysis and sensitivity analysis. Result This review included 18 studies involving 45,760 subjects, all of which were of medium or high quality. Meta-analysis results represented that, the pooled estimated acceptance rate of COVID-19 vaccine among HCWs in China was 78% (95%CI: 73–83%), and the pooled acceptance rate in 2021 (82%, 95%CI: 78–86%) was significantly higher than that in 2020 (73%, 95%CI: 65%-81%). Subgroup analysis showed different acceptance rates for COVID-19 vaccine among HCWs with different characteristics. Conclusion The result revealed that HCWs in China generally have a high acceptance rate of COVID-19 vaccines, but the acceptance rate varies with different characteristics of the population. Therefore, corresponding training should be carried out for HCWs with different characteristics, and they should play an exemplary and leading role in COVID-19 vaccination, so as to improve the vaccination rate of the whole population and form an immune barrier at an early date.