Miracle-dz/UniFAR-FTUs huggingface dataset:
Use of the JAK1/JAK2 inhibitor ruxolitinib in the treatment of patients with myelofibrosis

Myelofibrosis (MF), including primary MF and MF secondary to polycythemia vera or essential thrombocythemia, is a chronic, clinically heterogeneous hematologic malignancy characterized by inefficient hematopoiesis, bone marrow fibrosis, and shortened survival. Typical clinical manifestations include progressive splenomegaly, debilitating symptoms, and anemia. MF is associated with dysregulation of Janus kinase (JAK)-signal transducer and activator of transcription (JAK/STAT) pathway affecting hematopoiesis and inflammation. Ruxolitinib, an oral JAK1/JAK2 inhibitor, was approved for the treatment of patients with intermediate or high-risk MF based on the results of 2 phase 3 studies (Controlled MyeloFibrosis Study with Oral JAK Inhibitor Treatment [COMFORT]-I and COMFORT-II). In these trials, ruxolitinib treatment was associated with reductions in spleen size and symptom burden, and improvements in quality of life. The most common adverse events were dose-dependent cytopenias, which were managed by dose modifications, treatment interruptions, and red blood cell transfusions (for anemia). Ruxolitinib was effective regardless of MF type, risk status, or JAK2V617F mutation status, and across various other MF subpopulations. Two-year follow-up data from the COMFORT trials also demonstrate that ruxolitinib has durable efficacy and may be associated with a survival advantage relative to placebo and best available therapy. Preliminary data from ongoing studies support possible dosing strategies for patients with low platelet counts.
Measuring SO2 Emission Rates at Kīlauea Volcano, Hawaii, Using an Array of Upward-Looking UV Spectrometers, 2014–2017

The Hawaiian Volcano Observatory uses an array of ten fixed, upward-looking ultraviolet spectrometer systems to measure SO2 emission rates at 10-second sample intervals from the Kīlauea summit. We present Kīlauea SO2 emission rates from the volcano’s summit and Middle East Rift Zone during 2014-2017 and discuss the major sources of error for these measurements. Due to the wide range of SO2 emissions encountered at the summit vent, we used a variable wavelength spectral analysis range to accurately quantify both high and low SO2 column densities. We present case studies comparing the measured emission rates from the fixed spectrometer array to independent road and helicopter-based traverse measurements and evaluate the magnitudes and sources of uncertainties for each method. To address the challenge of obtaining accurate plume speed measurements, we examine ground-based wind-speed, plume speed tracking via spectrometer, and SO2 camera derived plume speeds. Our analysis shows that 1) the summit array column densities calculated using a dual fit window, are within -6 to +22% of results obtained with a variety of other conventional and experimental retrieval methods 2) emission rates calculated from the summit array located ~3 km downwind of the Overlook vent provide the best, practical estimate of summit SO2 release under normal trade wind conditions 3) ground-based anemometer wind speeds are 22% less than plume speeds determined by cross-correlation of plume features 4) our best estimate of average Kīlauea SO2 release for 2014-2017 is 5100 t/d, which is comparable to the space-based OMI emissions of 5518 t/d 5) short-term variability of SO2 emissions reflect Kīlauea lava lake dynamics.
Wanting to Be Boss and Wanting to Be Subordinate: Effects on Performance Motivation

Does dyad members' motivation to take on a high or low power position influence the dyad's performance motivation when assigned to hierarchical roles? Participants in 69 dyads (33 all-women, 36 all-men) indicated whether they preferred the high-power role (owner of an art gallery) or the low power role (assistant to the owner). Power roles were then randomly assigned. The dyad's interaction during task solving was videotaped. Uninvolved coders rated performance motivation as the degree of quality of the superior's and the subordinate's task contributions and effort put into the task. Performance motivation was better if the boss preferred the high power to the low power role, irrespective of the subordinate's role preference. Leadership effectiveness is thus affected by the superior's power motivation.
Punjabi Documents Clustering System

Text document clustering inherits its qualities from Natural Languages Processing, Machine Learning and Information Retrieval. For unsupervised document organization, automatic topic extraction and fast information filtering and accuracy in retrieval, this is an effective method. Many clustering algorithms are available for unsupervised document organization and its retrieval thereof. The documents for text clustering are merely considered as an assortment of words in traditional approaches to clustering. The semantic relationship of the words should form the decisive base for clustering, which is generally conveniently forgotten albeit the information is vital for the purpose. A new method for generating frequent phrases by analyzing the semantic relations between the words in a sentence is discussed. Karaka list captures the semantic relations, which is a grammatical connector for connecting Nouns, Pronouns and Verbs in a sentence. This new clustering method utilizes an amalgamation of the theories behind Karaka Analyzer, Frequent Item sets and Frequent Word Sequences. Results are indicative of the fact that New Hybrid approach performs better in terms of Number of Clusters, Meaningful label of Clusters and effectiveness of clustering for those documents which do not have desired information in frequent phrases. Use of semantic features is the key to better results.
COVERAGE, DIVERSITY, AND COHERENCE OPTIMIZATION FOR MULTI-DOCUMENT SUMMARIZATION

A great summarization on multi-document with similar topics can help users to get useful in¬for¬ma¬tion. A good summary must have an extensive coverage, minimum redundancy (high diversity), and smooth connection among sentences (high coherence). Therefore, multi-document summarization that con¬siders the coverage, diversity, and coherence of summary is needed. In this paper we pro¬pose a novel method on multi-document summarization that optimizes the coverage, diversity, and co¬her¬ence among the summary's sentences simultaneously. It integrates self-adaptive differential evo¬lu¬tion (SaDE) al¬gorithm to solve the optimization problem. Sentences ordering algorithm based on top¬ic¬al closeness ap¬proach is performed in SaDE iterations to improve coherences among the summary's sen¬tences. Ex¬pe¬ri¬ments have been performed on Text Analysis Conference (TAC) 2008 data sets. The ex¬perimental re¬sults showed that the proposed method generates summaries with average coherence and ROUGE scores 29-41.2 times and 46.97-64.71% better than any other method that only consider coverage and di¬versity, re-spect¬ive¬ly.
Generation of gua1 deletion using polymerase chain reaction (PCR)-mediated gene disruption method in fission yeast, Schizosaccharomyces pombe

Gua1 gene in Schizosaccharomyces pombe encodes inosine 5′-monophosphate dehydrogenase (IMPDH), which catalyzes the first step in de novo biosynthesis of guanosine monophosphate (GMP). Knock-out cassette was constructed with polymerase chain reaction (PCR)-based gene targeting technique for deletion of gua1 gene in S. pombe and this knock-out cassette was transformed to S.s pombe wild type (972h-). Knock-out cassette contains 653 and 285 bp sequences which are upstream and downstream of gua1 gene, respectively, in S. pombe genome and kanamycin resistance gene obtained from pFA6 plasmid. After transformation using lithium acetate method, knock-out cassette is aimed at replacing with the sequences of gua1 gene via homologous recombination. The transformant 972h- colonies which integrated knock-out cassette to the genome via homologous recombination are selected in YEA medium with antibiotic G418 after transformation and in this step, possible mutant colonies in gua1 gene were determined. Finally, colony PCR techniques were performed to control whether the deletion is made in the right place or not. The results show that the gua1 gene deleted strain was obtained. Key words: Fission yeast, deletion, gua1 gene, knock-out cassette, inosine 5′-monophosphate dehydrogenase (IMPDH).
A Distributed Perspective on Instructional Leadership in International Baccalaureate (IB) Schools

Purpose: The purpose of this study is to provide a better understanding of how instructional leadership responsibilities are distributed in International Baccalaureate (IB) schools in East Asia. Research Design: Case studies were conducted in five international schools located in Thailand, Vietnam, Hong Kong, and China. These schools were selected on the basis of location in East Asia, the offering of the full continuum of the IB’s three programs, and evidence of prior academic success. In total, 68 teachers and administrators and 25 students were interviewed. Qualitative analysis of the interview data was conducted using pattern coding. Findings: Three broad instructional leadership practices were identified: curriculum articulation, cross-program activities, and strategic staffing. These appeared to enhance curriculum consistency and coherence across the three IB programs, a problem that had been identified in full-continuum IB schools. The qualitative data suggested that distributed instructional leadership forged and sustained professional interactions among staff across programs and organizational units. Conclusions: IB schools globally are often structurally separated into two or three organizational units (e.g., primary, middle, high school). These units operate IB programs that, despite their common origin and international philosophy, employ distinct pedagogical and curricular approaches. The findings reinforce the importance of acting intentionally to distribute responsibilities for instructional leadership widely throughout the school. They also support the assertion that international schools offer a unique and fruitful context for studying distributed instructional leadership.
Design and implementation of a bi-directional 3 phase converter for a 30kW range extender application

Increasing fuel prices and political pressure to reduce the pollution in the mobile transport lead to new technologies for electric transport. PEEC-Power B.V. is developing a range extender for parallel hybrid vehicles and wants to contribute to the transition towards electric driving. The range extender consists of three subsystems: a combustion engine, a generator and the power electronic system. This thesis is about the design and implementation of this power electronic system. Different circuit topologies are investigated and the bi-directional full bridge topology is chosen based on costs, controllability, weight and efficiency. In order to control the full bridge converter several PWM and control methods are investigated and an optimal solution is proposed based on harmonic distortion, switching losses, robustness and DSP implementation. A test setup is build and the proposed PWM and control method is implemented. Measurements are carried out on switching behavior, efficiency and harmonic distortion. The measurement results are compared to the calculated and simulated results. Based on this comparison conclusions and recommendations are presented.
Stock Market Reactions due to Announcements of Consumer Price Index and the Investigation of Endogeneity

In the financial market the very peculiar and key focus is about the trading volume response to Consumer price index (CPI). Therefore, taking CPI as one of the important economic variables, the Karachi Stock Exchange-100 index trading volume was investigated in connection with the CPI. The outcomes of this study suggested that CPI has a major association with the KSE-100 index trading volume. The statistical test further elaborated this significance and has revealed a negative relationship between CPI “Consumer price index” and “KSE-100 index trading volume”. Another interesting key feature to this research was the presence of endogeneity in the data used for the research.
Modification of normalised difference water index (NDWI) to enhance open water features in remotely sensed imagery

The normalized difference water index (NDWI) of McFeeters (1996) was modified by substitution of a middle infrared band such as Landsat TM band 5 for the near infrared band used in the NDWI. The modified NDWI (MNDWI) can enhance open water features while efficiently suppressing and even removing built‐up land noise as well as vegetation and soil noise. The enhanced water information using the NDWI is often mixed with built‐up land noise and the area of extracted water is thus overestimated. Accordingly, the MNDWI is more suitable for enhancing and extracting water information for a water region with a background dominated by built‐up land areas because of its advantage in reducing and even removing built‐up land noise over the NDWI.
Evaluation of the nutritional value of soaked-boiled-fermented Java plum (Syzygium cumini) seed meal for poultry

Chemical analysis, apparent metabolizable energy (MEn), and one feeding trial were conducted to evaluate the nutritional value of Java plum seeds (JPS) that had been subjected to a combination of soaking, boiling, and fermentation (SBF). Five broiler starter diets were formulated with the processed Java plum seed meal (JPSM) comprising 0, 80, 160, 240, and 320 g/kg of the diet. The JPS before and after processing contained 910±5.30 and 888±6.10 g DM; 44.2±0.940 and 48.1±1.02 g CP; 886±9.90 and 888±6.54 g NFE; and 13.2± 0.165 and 13.3±0.154 MJ calculated metabolizable energy; 24.4±1.33 and 9.17±0.940 g tannins per kg, respectively. The MEn value of the processed JPSM was 14.7±0.973 MJ/kg. Feed intake (FI), weight gain (WG), and feed efficiency (FCR) of broiler chicks decreased (R 2 ˃ 0.850) with increasing JPSM in the diet. At 80 and 320 g/kg inclusion, FI, WG, and FCR were depressed by 16.0 and 34.1%, 20.2 and 42.5%, and 4.90 and 12.5%, respectively. Liver, heart, and pancreas weights relative to body weight were not significantly (P ˃ 0.05) affected. However, caecum, gizzard, and intestine weights increased (R 2 ˃ 0.800), while the heart weight decreased (R 2 = 0.772) with increasing JPSM in the diet. At 80 and 320 g/kg JPSM inclusion, weights of caecum, intestine, and gizzard increased by 48.5 and 68.2%, 18.8 and 43.5%, and 9.55 and 19.2%, respectively. Inclusion of JPSM in chick diets adversely (P < 0.05) affected nitrogen retention (NR), nitrogen digestibility (ND), dry matter digestibility (DMD), and excreta water content (EWC). At 320 g/kg JPSM inclusion, NR, ND, DMD, and EWC were depressed by 30.8, 12.6, 0.42, and 2.45%, respectively. No mortality was recorded at 320 g/kg JPSM inclusion. The SBF did not improve the nutritional value of JPS for poultry production.
Design Method Based on Normalized Functions for a Toroidal Inductor Applied to Power-Quality Evaluation

The design method for a low-cost toroidal inductor is proposed as an alternative to power-quality evaluation. The method is based on well-known tools by the engineers in which is presented the relationships that exist between equivalent circuit and transfer function of a toroidal inductor. The proposed design method has been explained with normalized functions based on physical parameters of a toroidal inductor. This work presents the main arguments of the suggested methodology and as demonstration of the design method as function of normalized parameters, is developed a current-signal sensor which has been validated in the laboratory by the EN-50160-2-2 standard to evaluate the power quality in home use loads.
Assessment instruments of functioning in Brazilian elderly and the ICF: a systematic review

Introduction: Under the new conceptual model described by the International Classification of Functioning Disability and Health (ICF) for a biopsychosocial health analysis, it is necessary to consider that it is not arising only from biological conditions, but also environmental, social, cultural and politics involved in this process. Objective: To review the publications that had the Brazilians elderly functioning as outcome by analyzing the instruments used and to verify its consistency with the ICF model. Methods: A systematic review of the Brazilian literature on elderly was performed in SciELO, PubMed, Scopus, and Lilacs databases. Publications starting in 2001, in English, Portuguese or Spanish, studies with experimental design or intervention, having the Brazilian elderly as the only subject. For evaluating the quality of the papers, the Downs and Black checklist were used. Results: From 3070 items first found in the research, 29 articles remained for this study. Of these, 25 instruments were used to measure the eldery functioning. The frequency of the ICF domains were: health condition (0.28%), body structure and function (1.71%), activity (82.34%), participation (3.42%), environmental factors (12.25%) and personal factors (0%). Conclusion: Despite the ICF be much discussed today, it was possible to detect remaining gaps in the studies about the subject. The results of this study indicate that the conceptual model has not being fully and equitably used when it comes to the eldery functioning.
Single bend wiring on surfaces

The following problem of rectilinear routing is studied: given pairs of points on a surface and a set of permissible orthogonal paths joining them, whether is it possible to choose a path for each pair avoiding all intersections. We prove that if each pair has one or two possible paths to join it, then the problem is solvable in quadratic time, and otherwise it is NP-complete. From that result, we will obtain that the problem of 5nding a surface of minimum genus on which the wires can be laid out with only one bend is NP-hard. 2002 Elsevier Science B.V. All rights reserved.
A preliminary 1‐D model investigation of tidal variations of temperature and chlorinity at the Grotto mound, Endeavour Segment, Juan de Fuca Ridge

Tidal oscillations of venting temperature and chlorinity have been observed in the long‐term time series data recorded by the Benthic and Resistivity Sensors (BARS) at the Grotto mound on the Juan de Fuca Ridge. In this study, we use a one‐dimensional two‐layer poroelastic model to conduct a preliminary investigation of three hypothetical scenarios in which seafloor tidal loading can modulate the venting temperature and chlorinity at Grotto through the mechanisms of subsurface tidal mixing and/or subsurface tidal pumping. For the first scenario, our results demonstrate that it is unlikely for subsurface tidal mixing to cause coupled tidal oscillations in venting temperature and chlorinity of the observed amplitudes. For the second scenario, the model results suggest that it is plausible that the tidal oscillations in venting temperature and chlorinity are decoupled with the former caused by subsurface tidal pumping and the latter caused by subsurface tidal mixing, although the mixing depth is not well constrained. For the third scenario, our results suggest that it is plausible for subsurface tidal pumping to cause coupled tidal oscillations in venting temperature and chlorinity. In this case, the observed tidal phase lag between venting temperature and chlorinity is close to the poroelastic model prediction if brine storage occurs throughout the upflow zone under the premise that layers 2A and 2B have similar crustal permeabilities. However, the predicted phase lag is poorly constrained if brine storage is limited to layer 2B as would be expected when its crustal permeability is much smaller than that of layer 2A.
Tell me your ethnicity and I will tell you what you are: culture as a key factor of creativity in business

Culture is an important element of creativity which makes novel ideas useful and valuable for customers, for example, in the construction industry. This grounded theory ex- ploratory mixed methods study seeks to establish the preferred housing variables of two con- trasting cultural groups. The study also seeks to establish the existence of a relationship be- tween ethnicity and the preferred housing style, and to propose a practical, consumer- dwelling choice marketing research approach. The research took place in two stages—it be- gan with 29 in-depth interviews in Turkey and Russia and followed by email survey- questionnaire, of which 237 useful replies were received from customers of two real estate companies based in Istanbul and Moscow. All quantitative data was analysed using IBM-SPSS- 20 software. Findings indicated a positive relationship between belonging to Turkish or Rus- sian cultural group and preference of the certain group of cultural variables in housing styles.
Real time demand response using renewable energy resources and energy storage in smart consumers

There is a pressing need to accelerate the development of low-carbon energy technologies in order to address the global challenges of energy safety, climate changes and economic growth. Smart grids are particularly important as they enable several other low-carbon energy technologies, including electric vehicles, variable renewable energy sources and demand response. This paper describes an optimization model to adjust the hourly load level of a given consumer in response to hourly electricity prices with consideration of renewable energy resources and energy storage. The objective of the model is to minimize the energy cost of the consumer. Price uncertainty and uncertainties in making prediction about solar PV and wind power generation are modeled through robust optimization techniques. The model materializes into a simple linear programming algorithm that can be easily integrated in the Energy Management System of a household or a small business. A simple bidirectional communication device between the power supplier and the consumer enables the implementation of the proposed model. Simulations results confirm the performance of the proposed model. (4 pages)
Almost orthogonality and a class of bounded bilinear pseudodifferential operators

Several results and techniques that generate bilinear alternatives of a celebrated theorem of Calderón and Vaillancourt about the L2 continuity of linear pseudodifferential operators with symbols with bounded derivatives are presented. The classes of bilinear pseudodifferential symbols considered are shown to produce continuous operators from L2 × L2 into L1.