Miracle-dz/UniFAR-FTUs huggingface dataset:
Response to letter by Spector and Lieblich

Dear Editor, Thank you for the opportunity to reply to the <<Letter regarding ‘Comparison between low-cost marker-less and high-end marker-based motion capture systems for the computer-aided assessment of working ergonomics’ by Patrizi et al. and research reproducibility>>. We are pleased to respond to Dr. Spector and Dr. Lieblich’s comments and to clarify some aspects of our paper (Patrizi, Pennestrì, and Valentini 2016). As a general comment, we underline that the main purpose of our paper was to report in the field comparisons of the Microsoft Kinect V1 motion capture system with a highend marker-based photogrammetric system. To the best of our knowledge, this was novel. At the time of submission and revision of our paper, we were not aware of the contribution by Spector et al. (2014) and none of the reviewers prompted to include it. Compared with our study, Spector et al. (2014) report an investigation performed in a laboratory rather than the workplace. In the laboratory situation, the movements are standardised and the methodology can be optimised. Likewise, multimedia recordings and reproducibility can be more easily controlled. We fully agree with the necessity of ‘. reporting research in such a manner that allows reproduction in subsequent investigations’. There are methodological difficulties, however, in managing this in real-world application. All the measurements in our paper were performed in an Italian factory which produces ceramic goods (the brand was not disclosed for commercial reasons). In such scenarios, although it is possible to define a rigorous methodology, it is not always feasible to adhere to it strictly. In our study, the workers monitored were requested to behave as usual; no postural constraints were imposed (i.e. predefined position/motion). The environment was noisy, dusty and not very clean. The purpose and value of our study was, in fact, the appraisal of the Kinect capabilities for ergonomics assessments in unstructured workplace conditions and within real industrial environments. Addressing the specific comments of Spector and Lieblich, we respond as follows:
Identification of polymorphisms in the Caspase‐3 gene and their association with lung cancer risk

Caspase‐3 (CASP‐3) is a primary effector CASP that executes programmed cell death, and it plays an important role in the development and progression of cancer. Polymorphisms in the CASP‐3 gene may influence CASP‐3 production and/or activity, thereby modulating the susceptibility to lung cancer. To test this hypothesis, we first screened for polymorphisms in the CASP‐3 gene by direct sequencing of genomic DNA samples from 27 healthy Koreans, and then evaluated their associations with lung cancer in a case–control study that consisted of 582 lung cancer patients and 582 healthy controls. Individuals with at least one variant allele of the −928A > G, 77G > A, and 17532A > C polymorphisms were at a significantly decreased risk for lung cancer in comparison to the carriers with each homozygous wild‐type allele [adjusted odds ratio (OR) = 0.79, 95% confidence interval (CI) = 0.62–1.00, P = 0.05; adjusted OR = 0.78, 95% CI = 0.61–0.99, P = 0.04; and adjusted OR = 0.74, 95% CI = 0.58–0.95, P = 0.02, respectively]. Consistent with the results of genotyping analysis, the GAGC haplotype carrying the variant allele at all of the −928A > G, 77G > A, and 17532A > C loci was associated with a significantly decreased risk of lung cancer compared to the AGGA haplotype carrying no variant alleles at the three loci (adjusted OR = 0.66, 95% CI = 0.51–0.86, P = 0.002 and Bonferroni corrected P = 0.008). These results suggest that the CASP‐3 polymorphisms and their haplotypes contribute to the genetic susceptibility to lung cancer. © 2007 Wiley‐Liss, Inc.
Improved pulse sequences for pure exchange solid‐state NMR spectroscopy

Spin‐exchange experiments are useful for improving the resolution and establishment of sequential assignments in solid‐state NMR spectra of uniformly 15N‐labeled proteins oriented macroscopically in phospholipid bilayers. To exploit this advantage fully, it is crucial that the diagonal peaks in the two‐dimensional exchange spectra are suppressed. This may be accomplished using the recent pure‐exchange (PUREX) experiments, which, however, suffer from up to a threefold reduction of the cross‐peak intensity relative to experiments without diagonal‐peak suppression. This loss in sensitivity may severely hamper the applicability for the study of membrane proteins. In this paper, we present a two‐dimensional exchange experiment (iPUREX) which improves the PUREX sensitivity by 50%. The performance of iPUREX is demonstrated experimentally by proton‐mediated 15N–15N spin‐exchange experiments for a 15N‐labeled N‐acetyl‐L‐valyl‐L‐leucine dipeptide. The relevance of exchange experiments with diagonal‐peak suppression for large, uniformly 15N‐labeled membrane proteins in oriented phospholipid bilayers is demonstrated numerically for the G‐protein coupled receptor rhodopsin. Copyright © 2004 John Wiley & Sons, Ltd.
Protein fold recognition using sequence‐derived predictions

In protein fold recognition, one assigns a probe amino acid sequence of unknown structure to one of a library of target 3D structures. Correct assignment depends on effective scoring of the probe sequence for its compatibility with each of the target structures. Here we show that, in addition to the amino acid sequence of the probe, sequence‐derived properties of the probe sequence (such as the predicted secondary structure) are useful in fold assignment. The additional measure of compatibility between probe and target is the level of agreement between the predicted secondary structure of the probe and the known secondary structure of the target fold. That is, we recommend a sequence‐structure compatibility function that combines previously developed compatibility functions (such as the 3D‐1D scores of Bowie et al. [1991] or sequence‐sequence replacement tables) with the predicted secondary structure of the probe sequence.
Wireless Systems Maximum a posteriori decorrelating receiver for MC-CDMA systems

In this letter, we propose a maximum a posteriori decorrelating receiver (DR) for multicarrier code division multiple access (MC-CDMA) systems. The decorrelating receiver consists in a maximum a posteriori combining of an uncorrelated version of the signal demodulated over the different subcarriers. The DR performance is compared to that of the conventional receiver (CR) which is based on a maximum ratio combining strategy. Copyright © 2006 AEIT.
Search engines: a first step to finding information: preliminary findings from a study of observed searches

Introduction. This is a working paper which aims to present the preliminary results of a study into the search behaviours of the general public. The paper reports on the findings of the first six months of an eighteen-month data collection excercise. Methods. Detailed observations were made of nine volunteers, engaged on a variety of search tasks. Some of the tasks were self-selected, others were set by the researchers. Most tasks however, were designed to enable the volunteers to search within their own areas of interest and expertise. Analyses. A set of 'search dimensions' is proposed and qualitative findings based on these are presented. In addition, some initial quantitative findings are discussed. Result. Findings to date suggest that the best search strategy is a combination of simplicity and scrutiny. Volunteers who entered a few search terms but then carefully studied the results, appeared to be more successful than those who attempted to be prescriptive and entered a long series of terms.
The Effect of Dream (Stage REM) Deprivation on Adaptation to Stress

&NA; The role of dreaming in the assimilation and mastery of new experiences was examined in this study. Previous work had shown that a film of an autopsy can evoke measurable psychologic and physiologic indices of anxiety. Adaptation to the experience was indicated by lower levels of anxiety during a second viewing of the film. We examined the effect of dream (Stage REM) deprivation on adaptation to the second viewing. Between the first and second viewings, 9 subjects were dream deprived, 5 had normal sleep and 6 were awakened from non‐REM sleep. For those who showed a significant anxiety response to the first viewing, the dream deprived group showed significantly less adaptation to the second viewing than the other two groups. These results support the hypothesis that dreaming aids adaptation to anxiety‐provoking stimuli.
Edge reflection type SAW resonators on silicon substrate using ZnO thin films

A compact SAW resonator on silicon substrate has been proposed based on complete reflection property of shear horizontal surface waves at free edges and the Love wave generation capability of ZnO film in conjunction with IDT, the proposed device was fabricated and characterized. Love waves are excited in the overlaid ZnO film on silicon substrate and vertical grooves are micromachined into silicon substrate to form free edges of the device in order to facilitate the total reflection of Love waves. The phase velocity and electromechanical coupling coefficient dispersion characteristics of various layered configurations with respect to thickness of ZnO were obtained through finite element simulations. Edge reflection type SAW resonators were designed using equivalent circuit method for fabrication process and the devices were characterized for S11 parameters. Q factor of 498.5 at resonance frequency of 261.72 MHz was achieved for ZnO/IDT/Si configured SAW resonator on silicon substrate.
[Time-series analysis on road traffic injury in China].

OBJECTIVE To establish the predictive models of road traffic injury(RTI) in China, to know the trend of RTI, and to provide the reference data for controlling RTI in China. METHODS The China RTI data from 1951 to 2003 were collected, and in view of the problem of missing values, the method of intrapolation was adopted. The Box-Jenkins technique was used to analyze and predict the trend of RTI in China. Following the process for stationary time-series analysis, model identification, parameter estimation and model diagnosis, the predictive equation for RTI would be established. RESULTS A series of predictive equations on RTI were finally established based on ARIMA models. The curve fitting is effective and the predictive data of RTI in 2003 are close to the true statistical data. CONCLUSION The time-series model thus established proves to be of significant usefulness in RTI prediction.
Using a tangible interactive tabletop to learn at school: empirical studies in the wild

We describe in this article the results of three-years study of using a Tangible Tabletop Interface (TTI) for the development of student learning in spatial reasoning abilities. In partnership with the French Department of Education and teachers, we have designed and built a serious game in mathematics, called The Game of Towers for the TangiSense 2 interactive tabletop. Then, we conducted « in the wild » experiments with 68 students. As part of a first study, we compared the learning outcomes of two groups of students (Gr. Traditional vs. Gr. TTI). The results of this study have encouraged us to make a second experiment. In the latter, we analyzed child participation (physical and verbal) and the social modes of knowledge co-construction when they played the game on the TTI. The results showed that students improved their performance by playing the game on the TTI and collaborated through externalization and conflict-oriented consensus.
Positron Emission Tomography for Serial Imaging of the Contused Adult Rat Spinal Cord

We investigated whether small-animal positron emission tomography (PET) could be used in combination with computed tomography (CT) imaging techniques for longitudinal monitoring of the injured spinal cord. In adult female Sprague-Dawley rats (n = 6), the ninth thoracic (T9) spinal cord segment was exposed by laminectomy and subsequently contused using the Infinite Horizon impactor (Precision System and Instrumentation, Lexington, KY) at 225 kDyn. In control rats (n = 4), the T9 spinal cord was exposed by laminectomy but not contused. At 0.5 hours and 3, 7, and 21 days postinjury, 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG) was given intravenously followed 1 hour later by sequential PET and CT. Regions of interest (ROIs) at T9 (contused) and T6 (uninjured) spinal cord segments were manually defined on CT images and aided by fiduciary markers superimposed onto the coregistered PET images. Monte Carlo simulation revealed that about 33% of the activity in the ROIs was due to spillover from adjacent hot areas. A simulation-based partial-volume compensation (PVC) method was developed and used to correct for this spillover effect. With PET-CT, combined with PVC, we were able to serially measure standardized uptake values of the T9 and T6 spinal cord segments and reveal small, but significant, differences. This approach may become a tool to assess the efficacy of spinal cord repair strategies.
Non-AIDS primary CNS lymphoma: first example of a durable response in a primary brain tumor using enhanced chemotherapy delivery without cognitive loss and without radiotherapy.

PURPOSE Radiographic tumor response and survival were evaluated in patients receiving methotrexate-based chemotherapy with osmotic blood-brain barrier disruption with or without antecedent cranial radiation. PATIENTS AND METHODS Fifty-eight non-AIDS patients (38 males, 20 females) with histologically confirmed primary central nervous system lymphoma, primarily large cell or immunoblastic, were treated at the Oregon Health Sciences University from January 1982 through March 1992. Group 1 patients (n=19) received cranial radiation prior to referral; Group 2 (n=39) received initial blood-brain barrier disruption chemotherapy. Ages ranged from 5 to 71 years (median, 57); Karnofsky performance status was 40% to 100% on inclusion (median, 80) and all underwent extensive baseline neuropsychological evaluation. RESULTS There was no significant difference in patient characteristics between the two groups. In 15 evaluable Group I patients, 14 demonstrated objective response and 7 of 14 (50%) achieved complete response. In Group 2, 34 of 35 evaluable patients demonstrated objective response, including 29 of 34 with complete response. Estimated median survival times for Group 1 and Group 2 patients were 16 and 41 months, respectively. Currently, 19 Group 2 patients and 2 Group 1 patients are alive. Extensive neuropsychological follow-up (up to 7 years from baseline) was completed in 23 patients, which demonstrated preservation or improved cognitive function in those receiving initial chemotherapy and blood-brain barrier disruption, most notably in patients older than 60 years. CONCLUSIONS A plateau in survival curves suggests that a portion of primary central nervous system lymphoma patients may be cured with chemotherapy and blood-brain barrier disruption without the neurologic sequelae associated with cranial radiation.
The Thyroglobulin: A Technically Challenging Assay for a Marker of Choice During the Follow-Up of Differentiated Thyroid Cancer

This glycoprotein of high molecular weight (660 kDa) is constituted by two identical subunits bound by disulphide-bridges. Each sub-unit contains 2 749 amino acids (Malthiery & Lissitzky, 1987 and Van de Graf et al., 1997). Its gene is situated on the chromosome 8 and different isoforms of Tg are secreted by alternative splicing. This molecule is heterogeneous by its degree of iodination (0.2 to 1.0%), of glycosylation, and by its contents in oses and in sialic acid (8 to 10%). The epitopic map of Tg revealed approximately about forty antigenic determinants, twelve epitopes grouped together in six domains (Piechaczyck et al., 1985). The central region of the Tg molecule is in majority immunoreactive (Henry et al, 1990).
Structural evidence for Nap 1-dependent H 2 AH 2 B deposition and nucleosome assembly

We had sent your revised manuscript file as well as the response to the referee concerns to two arbitrating advisors. We have now after some delay for which I apologise heard back from both arbitrating referees and their comments are included below. I am afraid that neither of the two offer support for publication of the revised manuscript in The EMBO Journal. As you will see, they both remain concerned about the conclusiveness of the study and find that significant additional data would be required to support the presented model.
A National US Study of Posttraumatic Stress Disorder, Depression, and Work and Functional Outcomes After Hospitalization for Traumatic Injury

Objective:To examine factors other than injury severity that are likely to influence functional outcomes after hospitalization for injury. Summary Background Data:This study used data from the National Study on the Costs and Outcomes of Trauma investigation to examine the association between posttraumatic stress disorder (PTSD), depression, and return to work and the development of functional impairments after injury. Method:A total of 2707 surgical inpatients who were representative of 9374 injured patients were recruited from 69 hospitals across the US. PTSD and depression were assessed at 12 months postinjury, as were the following functional outcomes: activities of daily living, health status, and return to usual major activities and work. Regression analyses assessed the associations between PTSD and depression and functional outcomes while adjusting for clinical and demographic characteristics. Results:At 12 months after injury, 20.7% of patients had PTSD and 6.6% had depression. Both disorders were independently associated with significant impairments across all functional outcomes. A dose-response relationship was observed, such that previously working patients with 1 disorder had a 3-fold increased odds of not returning to work 12 months after injury odds ratio = 3.20 95% (95% confidence interval = 2.46, 4.16), and patients with both disorders had a 5–6 fold increased odds of not returning to work after injury odds ratio = 5.57 (95% confidence interval = 2.51, 12.37) when compared with previously working patients without PTSD or depression. Conclusions:PTSD and depression occur frequently and are independently associated with enduring impairments after injury hospitalization. Early acute care interventions targeting these disorders have the potential to improve functional recovery after injury.
Sustainable organization capabilities in supply chain management

Sustainability has gained growing interests among both practitioners and academics with the environment that we are living in deteriorates. With the consumers’ advocate towards sustainability, companies nowadays are also trying to integrate the theme into theirs business operations thus developing sustainable organization capabilities that helps them to compete in the business world. The thesis picks up the angle of supply chain management to study the sustainable organization capabilities because greening the supply chain activities is also an area that’s increasingly gaining public recognition. The literature part of the thesis is fulfilled by reading previous literature on the topic thus providing guidelines for the research. The empirical part is done through the method of systematic review. The comparison between the two parts provides insights for further research. The objective of the thesis is define sustainable organizational capabilities through earlier literature and to explore its application within supply chain management field thus providing useful insights both for practitioners and academics. The author used a quantitative research method in conducting a qualitative research. The main methodological framework of the thesis is systematic literature review. In addition, for developing the search concept, triple bottom line and Porter’s value chain model are also engaged for providing guidelines for the study. The thesis engages systematic literature review as the main method for providing a comprehensive result of the current literature. With 226 defined search strings, the search took place between 2015 to year 2016. It covers the 5006 search hits, 2264 articles. Out of which, 24 are selected for final discussion. The results provide a comprehensive overview of current literature in sustainable organizational capabilities in supply chain management including: procurement, supplier assessment, IT and also some other miscellaneous supply chain organizational capabilities. In light to further research area, the author has also pointed out worthy exploring organization operations such as material management and warehousing management. Practical wise, the author provided profound suggestions to supply chain managers and top level managers in business operations.
Recombinant lipoproteins: implications for structure and assembly of native lipoproteins.

PERSPECTIVES AND OVERVIEW . •••. •• •••. •. •. • 403 Lipoprotein Structure and Metabolism 403 Apoprotein Structure and Properties 411 LIPID RECOMBINANTS RESEMBLING LIPOPROTEINS . •. •. 416 Recombinants of Surface Lipids . 416 Recombinants of Surface and Core Lipids: Emulsions and Microemulsions . 420 APOPROTEIN-SURFACE LIPID RECOMBINANTS , 426 ApoA-I-SurJace Lipid Recombinants 426 ApoA-II-Surface Lipid Recombinants 436 ApoC-SurJace Lipid Recombinants 438 ApoE-Surface Lipid Recombinants 438 ApoB-Surface Lipid Recombinants 439
On-Chip Dual-Band Rectangular Slot Antenna for Single-Chip Millimeter-Wave Identification Tag in Standard CMOS Technology

In this paper, an on-chip dual-band rectangular slot antenna is proposed and demonstrated for a new generation of high data rate, battery free, yet active millimeter-wave identification (MMID) system, which is fully integrated on a single-CMOS die. It, therefore, does not require any external components (padless) nor the traditional packaging. The single-antenna solution proposed in this paper addresses the overall system compactness, the cost, and the underlying technical challenges related to multifrequency reader-tag MMID system, such as the alignment between the reader’s and tag’s antennas (accurate line-of-sight, especially in a short-range communication system). The targeted 24/40-GHz compact antenna is a hybrid structure of a dielectric resonator antenna (DRA) and a coplanar waveguide-fed rectangular slot antenna in order to facilitate interconnections with other integrated circuit blocks. Design analyses of the antenna are presented. Dual dielectric resonator is optimized to enhance the antenna radiation efficiency as well as the gain over the two bands. Using a 65-nm-bulk CMOS process, a chip was fabricated and tested. The prototyped antenna exhibits a measured gain of −1 dBi at 24 GHz with a bandwidth of 19%, 0 dBi at 40 GHz with a bandwidth of 20%, and a radiation efficiency of 41% and 31%, at 24 and 40 GHz, respectively. The antenna occupies a compact size of $2.5\times 2.5\times2.5$ mm3 with DRA.
Interaction Design for Stratigraphic Analysis in Archaeology

Stratigraphic analysis, as defined my Harris in his Matrix approach, constitutes one of the most diffused analysis methods in archaeology. After a long collaboration with Archaeologists and other domain experts, we developed a second version of ArchMatrix, a system for graph-based interaction with excavation data. This system aims at solving the challenges that affect the archaeological practice given by its peculiar distributed environment. This position paper presents an overview of the research domain, the ArchMatrix system and the results of the preliminary usability tests with the end users.