Miracle-dz/UniFAR-FTUs huggingface dataset:
A Multienzyme Response is involved in the Phenomenon of Fasciola hepaticaResistance to Triclabendazole

The trematode Fasciola hepatica is the causative agent of a parasitic zoonosis known as fasciolosis, disease that affects humans and most species of domestic animals. Triclabendazole (TCBZ) is the most widely used fasciolicide, however, its indiscriminate use has led to the expression of anthelmintic resistance in the liver fluke. In the present work we evaluated “in vitro” the microsomes activity of different xenobiotic metabolizing enzymes of Phase I Carboxylesterases (CE) and Phase II the cytosolic activity of Glutathione S-Transferase (GST), Glutathione peroxidase (GPx) and Glutathione Reductase (GSR) in adults of F. hepatica susceptible (Cullompton strain) and resistant (Sligo and Oberon strains) to triclabendazole. In this work is detected a multienzyme response involving at all the family of enzymes glutathione dependent. Carboxylesterases activity did not differ between the different strains tested not being involved in the resistance phenomenon. These results contribute to the understanding of the mechanisms referred to the phenomenon of resistance to TCBZ.
Competition, Patent Protection, and Innovation in an Endogenous Market Structure

This study revisits the relationship between competition and innovation by incorporating an endogenous market structure (EMS) in a dynamic general equilibrium model. We consider that both innovative and non-innovative followers engage in Cournot competition with free entry. A competition-enhancing policy, which reduces entry cost, can stimulate the entry of innovative followers when the entry cost is high. However, when the entry cost is sufficiently low, the entry of non-innovative followers crowd-out innovative followers from the market. As a result, there is a non-monotonic relationship (inverted-V shape) between competition and innovation. Furthermore, we show that, while strengthening patent protection positively affects innovation when competition is sufficiently intense, the effect may be negative under milder competition. This suggests that a competition policy could complement a patent policy.
Favorable Trail Detection using ACO-Bellman Algorithm in VANETs

Vehicular ad hoc networks (VANETs) are the networks, which configured themselves, where the nodes are moving vehicles. These provide the communications required to deploy Intelligent Transportation Systems (ITS). A major dispute in VANETs is distribution of efficient and computable information because during communication nodes may leave or join the network dynamically. There is no guarantee about node availability at any given time, which leads to traffic problem, congestion problem. Therefore trailing the favorable path is a challengeable issue. Multiple routing algorithms have been developed for routing solution. In this paper the swarm-based algorithm has been presented, which helps to find out the optimal route using Bellman Ford algorithm. Ant colonization searches out the path using pheromones level. Higher the pheromone count of a route gives the optimal choice of path that can be used for packet delivery. Bellman Ford Algorithm optimizes the paths found by Ant Colony Optimization (ACO) by comparing the distance of source to all the nodes of network or cost given to the networks.
Validating the “Centering for Wisdom Assessment”: Assessing the Role of Contemplative Practices in the Cultivation of Practical Wisdom

This study provides empirical evidence to validate a new psychometric tool, the Centering for Wisdom Assessment (CWA), aimed at assessing the relationship between contemplative practices and the cultivation of the virtue of practical wisdom. In this article, we first describe the theoretical foundations of the CWA. Next, we present the results of five empirical studies that provide evidence of content, criterion, and construct validity. The results indicate that the CWA is internally consistent, relates to a theoretically similar construct of mindfulness, does not relate to religious commitment, and predicts—above and beyond mindfulness—relevant criterion variables including wisdom, hope, forgiveness, stress, anxiety, and depression. We also produced norms for CWA scores and showed that experts in contemplative prayer score differently on the CWA when compared to a matched sample from the general public. We conclude that the CWA is ready for use in pedagogical, spiritual, or leadership development contexts.
A Tri-National program for estimating the link between snow resources and hydrological droughts

Abstract. To evaluate how summer low flows and droughts are affected by the winter snowpack, a Tri-National effort will analyse data from three catchments: Alpbach (Prealps, central Switzerland), Gudjaretis-Tskali (Little Caucasus, central Georgia), and Kamenice (Jizera Mountains, northern Czech Republic). Two GIS-based rainfall-runoff models will simulate over 10 years of runoff in streams based on rain and snowfall measurements, and further meteorological variables. The models use information on the geographical settings of the catchments together with knowledge of the hydrological processes of runoff generation from rainfall, looking particularly at the relationship between spring snowmelt and summer droughts. These processes include snow accumulation and melt, evapotranspiration, groundwater recharge in spring that contributes to (the) summer runoff, and will be studied by means of the environmental isotopes 18O and 2H. Knowledge about the isotopic composition of the different water sources will allow to identify the flow paths and estimate the residence time of snow meltwater in the subsurface and its contribution to the stream. The application of the models in different nested or neighbouring catchments will explore their potential for further development and allow a better early prediction of low-flow periods in various mountainous zones across Europe. The paper presents the planned activities including a first analysis of already available dataset of environmental isotopes, discharge, snow water equivalent and modelling experiments of the (already) available datasets.
The Effect of Good Corporate Governance and Audit Quality on the Quality of Earning

The study examined the effect of corporate governance and audit quality on the quality of earnings. Corporate governance with board diversity is measured from the aspect of age and educational background members of the board of directors. Audit quality is measured based public accounting firm that audited by a big four firm/non-big four. The study measures the quality of earnings with discretionary accruals. This study used a sample of 160 non-financial companies listed on the Stock Exchange in 2010-2013, bringing the total observation in this study was 640 samples. The results provide empirical evidence that the age member of the board of directors does not affect the quality of earnings, a background study also does not affect the quality of earnings. Quality audits also show the results do not affect the quality of earnings.
Proceedings of the 11th International Workshop on Quality in Databases (QDB’16)

s of Invited Presentations Towards Rigorous Evaluation of Data Integration Systems It’s All About the Tools 29 Boris Glavic (Illinois Institute of Technology) Three Semi-Automatic Advisors for Data Exploration 30 Thibault Sellam (CWI) Graph-based Exploration of Non-graph Datasets 31 Udayan Khurana (IBM Research) Data Quality Management in Data Exchange Platforms An Approach for the Industrial Data Space in Germany 32 Christoph Quix (Fraunhofer FIT)
Agriculture without burning: restoration of altered areas with chop-and-mulch sequential agroforestry systems in the Amazon region

Traditional shifting cultivation in the Amazon region has caused negative environmental and social effects due to the use of fire. This type of agriculture has been criticized because it results in emission of large amounts of carbon into the atmosphere and a loss of soil productive potential. Since 1991, Project SHIFT-Tipitamba has researched this type of agriculture and, in a subsequent phase, attempted to propose solutions that could be adopted in northeastern Para, a region of ancient colonization in Amazon and highly anthropized based on an exclusively slash-and-burn agricultural system for more than 100 years. This paper presents some results obtained over two decades of research on these agricultural systems and proposes a method for the recovery or maintenance of the productive potential of these areas based on sequential agroforestry with secondary vegetation management and chop-and-mulch land preparation.
Act and Wait Concept in Force Controlled Systems With Discrete Delayed Feedback

A 1 DOF model of force control is considered with discrete delayed feedback. The act and wait control concept is introduced as a special case of periodic control: the feedback gain is constant for a sampling period (act), then it is zero for a certain number of periods (wait), then it is constant again, etc. It is shown that by applying the act and wait concept, the stability properties of the system improve and the force error caused by the Coulomb friction decreases. If the period of gain variation is larger than the feedback delay, then the system performance changes radically: the stability properties improve significantly, and the optimal control parameters can provide dead beat control. This way, by using the act and wait concept, the delay effects are eliminated from the system.Copyright © 2005 by ASME
The Pharmacotherapeutics of Methylphenidate and Atomoxetine for the Treatment of Childhood and Adolescent Attention Deficit-Hyperactivity Disorder

The most common class of drugs used to treat Attention Deficit-Hyperactivity Disorder (ADHD) are the central nervous stimulants. These drugs stimulate specific areas of the central nervous system and aim to reverse the symptoms of ADHD. Medication for ADHD can be divided into stimulants such as methylphenidate, dexamphetamine, and lisdex amphetaminedimesylate, and non-stimulants such as atomoxetine.
Comparative Performance Assessment In EU Pre-Accession Funds

European Union accession process designates candidate countries to adopt EU policies and laws to achieve concerted economic integration and social cohesion with the European system. Pre-accession funds are offered as the main instruments of EU enlargement programs in the course of harmonization. Each pioneered in different policy areas in line with the priorities of the development schemes of the candidate country; those funds motivate regional development, enhance civil participation and most importantly facilitate the Europeanization of the candidate country. The major challenge of pre-accession fund schemes derives from the ability of the candidate country to utilize those financial assistance programs in order to attain the most beneficial outcomes for all of the interest groups in the society. This certainly needs the configuration of the institutional templates and administrative capacity in the context of the requirements of the EU policies as well as the right establishment of fund allocation architectures that fit with the dynamics of the candidate country. This study aims at developing an analytical framework to assess the comparative performance and analyze the efficiency of the EU programs in the candidate countries, particularly in Turkey, in attaining the objectives of regional development policies. Such an analysis would contribute both to ascertain the absorption capacity of the regions for further EU funding and to identify the best practices in the three regional development grant schemes in Turkey, established and allocated under the pre-accession process. Comparative performance measurement approach can involve parametric or nonparametric methods. Major problem with a parametric approach is the requirement for a priori estimation of the type of method such as linear, non-linear etc. which may lead to a misspecified model. It might also get difficult to deal with multiple inputs and multiple outputs simultaneously. These problems can be overcome utilizing the non-parametric methods such as the Data Envelopment Analysis (DEA). DEA constructs an efficient boundary using the methods of linear programming and measures the distance of any unit from the boundary. It computes the relative efficiency of a unit and derives a variety of information about comparative
Food intake by the parrotfish Scarus ferrugineus varies seasonally and is determined by temperature, size and territoriality

On coral reefs, feeding by parrotfishes may prevent coral to macroalgal phase shifts by keeping algae in a cropped state. To predict the response of grazers to changing conditions, knowledge of the factors that affect feeding intensity is needed. Therefore, we studied food intake of the parrotfish Scarus ferrugineus on an inshore fringing reef in the southern Red Sea, Eritrea, where seasonality and extreme summer temperatures were expected to influence feeding rates. Bite rates (bites min(-1)), defecation rates (defecations min(-1)) and yield per bite (mass ingested bite(-1)) were estimated for 3 life-phase categories: 20 to 25 cm initial phase (IP), 30 to 35 cm terminal phase (TP) and 30 to 35 cm territorial terminal phase (TTP). The bite rates increased from low levels in the morning to peak values in the afternoon. IP bite rates increased linearly with seawater temperature. For TP, the temperature-bite rate relationship was quadratic, with maximum bite rates at similar to 32 degrees C and lower rates at higher temperatures. Yield per bite in both IP and TP did not differ with time of year. Throughout the year, the total daily bites were highest in IP and lowest in TTP, resulting in similar to 23% lower daily intake in TTP compared to similar-sized TP males. Daily intake of ash-free dry mass of epilithic algal matrix (g AFDM d(-1)) was 7.5 to 9.6 for IP, 12.4 to 17.5 for TP and 8.7 to 13.2 for TTP. Intake and defecation rates and hence gut turnover rates peaked from April to July. The quadratic temperature response of TP suggests that large individuals may be close to their upper thermal limit, implying that temperature rises are likely to negatively affect grazing by large-bodied parrotfishes.
Software for Higher-order Sensitivity Analysis of Parametric DAEs

We introduce AC-SAMMM (The AaChen platform for Structured Automatic Manipulation of Mathematical Models), a new software infrastructure for efficient transformation and evaluation of expressions and their higher-order derivatives. We describe the way this software can be used to perform automatically the translation of a model written in an equation-oriented language like Modelica into a subset of C/C++ and the generation of the model’s higher-order derivative code by algorithmic differentiation (AD) techniques. The derivatives are generated, using the derivative code compiler (dcc), an AD tool which provides source code transformation for a restricted but numerically relevant subset of C/C++. dcc can be applied repeatedly to its own output, to generate derivative codes of arbitrary order.
Flux-free growth of large superconducting crystal of FeSe by traveling-solvent floating-zone technique

A flux-free solution to the growth of large and composition homogeneous superconducting FeSe crystal is reported for the first time, which is based on the traveling-solvent floating-zone technique. The size of the crystal samples prepared by this approach is up to 15 × 6 × 2 mm3, being far bigger than previously reported in all dimensions, and the main phase of the crystals is of a single preferred orientation along the tetragonal (101) plane. X-ray diffraction analysis identifies the main phase to be the superconducting tetragonal β-FeSe. The superconducting transition temperature (TC) is determined to be 9.4 K by AC magnetic susceptibility and electronic transport measurements. A nearly perfect diamagnetic shielding of −97% is observed, indicating a bulk superconductivity in the crystal sample.
Genetic Identification of a Novel Locus (LB2) Regulates Bolting Time in Beta vulgaris

Bolting tendency in the facultative perennial species Beta vulgaris, which exhibits large intraspecific variation in bolting tendency, is a complex character governed by various environmental cues and multiple genetic factors. Significant variations in bolting time among annual Beta vulgaris ssp. maritima accessions were found. Three F2 populations derived from crosses between six annual beet accessions were analyzed for bolting tendency. Two populations (Bm38 and Bm49) exhibited phenotypic segregation ratios of 3:1 early-bolting and late-bolting which is expected for dominant-recessive inheritance of a monogenic trait. Phenotypic segregation ratio of the third population Bm49 was 15:1, early-bolting: late-bolting, which is expected for digenic dominant-recessive inheritance suggests the presence of a yet unidentified locus (LB2) which affects bolting time in annual Beta vulgaris.
Evaluation of selenium boluses on productive parameters and IgG in kids immunized with bacterin-toxoid

espanolRESUMEN Mexico tiene deficiencia de selenio en la mayor parte de su territorio, esto tiene consecuencias en la salud de los animales, disminuyendo la inmunidad y los parametros productivos, como el consumo de alimento y la ganancia de peso. El presente trabajo evaluo la suplementacion de selenio en cabritos en tres grupos de estudio; un grupo fue suplementado con selenio en forma oral a traves de bolos intarruminales (GBSe) (7 animales); otro grupo se suplemento con selenio de forma parenteral (GSeP) (7 animales) y un grupo control sin tratamiento (GC) (6 animales). Se evaluo el consumo de alimento, la ganancia de peso y la respuesta inmunitaria a traves de la medicion de IgG en suero contra una bacterina-toxoide. Se observo que los animales suplementados tuvieron mayores niveles de selenio en eritrocitos a diferencia del grupo control (GC) (p 0.05). La suplementacion al parecer no tuvo un efecto claro sobre el consumo de alimento y la ganancia de peso (p > 0.05). Se logro aumentar las concentraciones del mineral en eritrocitos en los animales suplementados. La respuesta inmune humoral fue influenciada por la suplementacion de selenio. EnglishABSTRACT Mexico has selenium deficiency in most of its territory, this has consequences on animal health, decreasing immunity and productive parameters, such as food consumption and weight gain. The present work evaluated the selenium supplementation in kids in three study groups; One group was supplemented with selenium orally through intraruminal boluses (GBSe) (7 animals); a group was supplemented with selenium parenterally (GSeP) (7 animals); a control group without treatment (GC) (6 animals). Feed intake, weight gain, and immune response were measured trough serum IgG levels against a bacterin-toxoid. It was observed that the supplemented animals had higher levels of selenium in erythrocytes unlike the control group (GC) (p 0.05). Supplementation apparently did not have a clear effect on feed intake and weight gain (p> 0.05). It was possible to increase the concentrations of the mineral in erythrocytes in the supplemented animals. The humoral immune response was influenced by selenium supplementation.
Hematological and immunological responses of Nile tilapia after polyvalent vaccine administration by different routes 1

Silva B.C., Martins M.L. , Jatobá A. , Buglione Neto C.C. , Vieira F.N. , Pereira G.V. , Jerônimo G.T. , Seiffert W.Q. & Mouriño J.L. P. 2009. Hematological and immunological responses of Nile tilapia after polyvalent vaccine administration by different routes. Pesquisa Veterinária Brasileira 29(11):874-880. Laboratório de Diagnóstico e Patologia em Aqüicultura, Departamento de Aqüicultura, Centro de Ciências Agrárias, Universidade Federal de Santa Catarina, Rodovia Ademar Gonzaga 1346, Itacorubi, Florianópolis, SC 88034-001, Brazil. E-mail: bcs85@hotmail.com The efficacy of a polyvalent bacterin vaccine against Aeromonas hydrophila, Pseudomonas aeroginosa and Enterococcus durans administered by different routes in Nile tilapia was assessed by analyzing hematological and immunological parameters 7 and 21 days after vaccination. Treatments consisted of: non-vaccinated tilapia; tilapia vaccinated by intraperitoneal injection with 2x10 formalin-inactivated bacteria·mL; tilapia vaccinated orally with 2x10 formalin-inactivated bacteria·g, feed for 5 days; tilapia vaccinated by immersion bath in 2x107 formalin-inactivated bacteria·mL-1, for 20 minutes. Vaccinated fish groups presented higher hematocrit, number of erythrocytes and leukocytes than the non-vaccinated group. Serum agglutination titer of intraperitoneally vaccinated fish was higher on both evaluation periods for the three bacteria strains. Only on day 21 post-vaccination fish from the oral and immersion vaccination groups presented higher serum agglutination titer than the non-vaccinated fish for A. hidrophyla and E. durans. Serum antimicrobial activity in vaccinated fish was higher for P. aeroginosa and E. coli than in non-vaccinated fish on both evaluation periods. The different vaccine administration routes stimulated hematological and immunological responses in Nile tilapia 21 days post-vaccination, but intraperitoneal vaccination presented higher total number of leukocytes, lymphocytes and serum agglutination titer.
The Possible Protective Effect of Losartan on Bleomycin-Induced Pulmonary Fibrosis in Albino Rats: A Histological And Immunohistochemical Study

The possible protective effect of Losartan, an angiotensin II receptor 1 antagonist, on bleomycininduced rat lung fibrosis was evaluated using histological and immunohistochemical techniques. Twenty adult male albino rats were divided into 4 groups each of five rats: Group I (control) given saline both I.V and orally, Group II given bleomycin 10mg/Kg/day I.V. , Group III given losartan 10 mg/Kg/day orally and Group IV given both bleomycin and losartan. Lung sections were taken at the 28th day of the experiment, stained with H&E, Masson’s trichrome, Orcein and immunohistochemical stain for α-SMA. This was followed by morphometric measurements and statistical analysis. The present study showed that bleomycin induced fibrotic changes in the lung in the form of thickened interalveolar septa filled with proliferated type II pneumocytes, fibroblasts and inflammatory cells with significant increase in collagen and elastic fibres deposition and in α-SMA immunoreactivity. It was found that concomitant treatment with losartan (Group IV) showed significant reduction in these fibrotic changes. The changes in α-SMA immunoreactivity in different groups showed the same pattern as those of collagen and elastic fibres. Thus, it could be concluded that myofibroblasts might play a pivotal role in induction of lung fibrosis and they could be a target of future therapeutic strategies
Medium-Term Budgetary Frameworks in the EU Member States

Effective budgetary management requires medium-term planning, by which the horizon for fiscal policymaking is extended beyond the annual budget cycle. All EU Member States have some sort of a Medium-Term Budgetary Framework (MTBF) in place but these frameworks differ substantially across countries in terms of political commitment, planning horizon, coverage, level of detail, formulation of targets, exclusion of certain items, carryover arrangements and binding nature. The experience of the recent crisis shows that allowing for more flexibility in the design of the MTBFs might be warranted. This, however, should be accompanied by more transparency in adjusting of the budgetary targets and increased role for independent monitoring of government's fiscal policy and execution.