Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impacts of the Clinical and Genetic Factors on Chronic Damage in Caucasian Systemic Lupus Erythematosus Patients

Objective: The purpose of this study was to determine the distribution of organ damage in a cohort of systemic lupus erythematosus (SLE) patients and to evaluate the roles of clinical and genetic factors in determining the development of chronic damage. Methods: Organ damage was assessed by the SLICC Damage Index (SDI). We analyzed a panel of 17 single-nucleotide polymorphism (SNPs) of genes already associated with SLE, and we performed a phenotype–genotype correlation analysis by evaluating specific domains of the SDI. Results: Among 175 Caucasian SLE patients, 105 (60%) exhibited damage (SDI ≥1), with a median value of 1.0 (IQR 3.0). The musculoskeletal (26.2%), neuropsychiatric (24.6%) and ocular domains (20.6%) were involved most frequently. The presence of damage was associated with higher age, longer disease duration, neuropsychiatric (NP) manifestations, anti-phospholipid syndrome and the positivity of anti-dsDNA. Concerning therapies, cyclophosphamide, mycophenolate mofetil and glucocorticoids were associated with the development of damage. The genotype–phenotype correlation analysis showed an association between renal damage, identified in 6.9% of patients, and rs2205960 of TNFSF4 (p = 0.001; OR 17.0). This SNP was significantly associated with end-stage renal disease (p = 0.018, OR 9.68) and estimated GFR < 50% (p = 0.025, OR 1.06). The rs1463335 of MIR1279 gene was associated with the development of NP damage (p = 0.029; OR 2.783). The multivariate logistic regression analysis confirmed the associations between TNFSF4 rs2205960 SNP and renal damage (p = 0.027, B = 2.47) and between NP damage and rs1463335 of MIR1279 gene (p = 0.014, B = 1.29). Conclusions: Our study could provide new insights into the role of genetic background in the development of renal and NP damage.
Effect Analysis of Clinical Pathway Nursing Combined with Humanized Nursing in Cerebral Infarction

Objective To make the application effect of clinical pathway nursing combined with humanized nursing clear in cerebral infarction. Methods Hundred patients who suffered from cerebral infarction had been hospitalized in our hospital and they become our study objects. By means of the random number table, they were separated into 50 cases both in the control group and in the observation group. The control group accepted the routine nursing, and the observation group accepted the clinical pathway nursing mixed with humanized nursing. The followings were compared including the hospitalization expenses and length of stay, National Institutes of Health Stroke Scale (NIHSS), Barthel index rating scale (BI), Fugl-Meyer Assessment (FMA), and the incidence of complications and recurrence rate. A comparison was made between the two groups about satisfaction with nursing. Results In contrast with the control group, the treatment expenses and length of stay in the observation group were considerably reduced (P < 0.05). In contrast, before nursing, the NIHSS marks of the two groups decreased considerably after nursing, and the scores of BI and FMA increased considerably, the NIHSS scores of the observation group were considerably lower than those of the control group, and the scores of BI and FMA were considerably higher than those of the control group (P < 0.05). In contrast with the control group (44.00%, 12.00%), the incidence of complications (22.00%) and recurrence rate (2.00%) in the observation group were considerably lower (P < 0.05). In contrast with the control group (72.00%), the satisfaction of nursing in the observation group (96.00%) was considerably higher (P < 0.05). Conclusion The application effect of clinical pathway nursing combined with humanized nursing in cerebral infarction is significant. It can not only effectively reduce hospitalization expenses and hospitalization time, improve neurological function, ability of daily living, and limb motor function but also reduce complications and recurrence and improve patients' satisfaction with nursing, which has a high clinical reference value.
Resonant frequency stabilization technique in series-series contactless energy transfer systems

A technique for stabilization of resonant frequency is proposed in this paper. An additional power circuit, a compensator that allows keeping constant resonance frequency was introduced by the authors. In the presented solution the resonant circuit frequency stabilization is achieved by forcing a zero phase shift between the current and the voltage of the main switching module.
Hostage incident management : preparedness and response of international non-governmental organisations

xiv CHAPTER 1: INTRODUCTION . 1 1.1 Problem Statement . 4 1.2 Research Questions . 5 1.3 Statement of the Study’s Aims and Objectives . 6 1.4 The Significance of Study . 6 1.5 Definition of Key Terms . 7 1.6 Summary statement . 11 CHAPTER 2: INGO OPERATIONS AND SECURITY MECHANISMS . 13 2.
The (Re)Construction of Black Womanhood Among Black College Women at PWIs: A Hip Hop Feminism Model of Multiple Identities

Abstract:The purpose of this study was to explore how Hip Hop informed the construction of gendered racial and sexual identities among Black women at predominately white institutions (PWIs). Ten Black women undergraduates at a PWI in the midwestern region of the US engaged in individual and focus group interviews, which included participating in an activity called the Soundtrack of My Life. The research team performed a constant comparative thematic analysis and identified three themes: (a) using Hip Hop to explore the multiplicity of Black womanhood, (b) unpacking the hypersexualization of Black women in Hip Hop, and (c) leveraging Hip Hop to navigate respectability politics. These findings explicate the specific ways Black women in college rely on Hip Hop to reconstruct Black womanhood via multiple intersecting identities. This study adds to previous identity frameworks by discussing the complex nature of Hip Hop culture's influence on the construction of Black womanhood among college women and proposes the Hip Hop feminism model of multiple identities.
APPLICATION OF FTA AND FMEA METHOD TO IMPROVE SUGAR PRODUCTION PROCESS QUALITY

Defective product is a product that has poor quality and do not meet the standart. This defective products can give a bad impact to company, such as high production costs and decreased image company. Several methods that can be used to improve the quality is Six Sigma DMAIC methodology, FTA, and FMEA method. This study is conducted for several purpose, they are to determine the value of sigma level on the process of sugar production in PT.PG. Krebet Baru, to determine the factors that cause defective products in the process of sugar production by the FTA method, and to make a suitable solution based on the FMEA defective causes. The process sigma level in PT.PG. Krebet Baru is 3.58. That value sigma level indicates PT. PG. Krebet Baru is a company that are still growing and need improvement. The primary cause of the defects in the production process is a factor of operator and machine. Mode of failure with the highest RPN at 210 is time for steam process is too long, so they need to install the equipment that can detect the water level on sugar. When this equipment is installed, the exact time for drying will be known and the amount of defective product will be decreased. Keywords : Defective Product, Six Sigma, DMAIC, FTA, FMEA.
A Miniaturized Microstrip Antenna for Ultra-wideband Applications

In this paper, the authors present an ultra-wideband (UWB) planar antenna with defected ground structure (DGS) for various wireless applications. The operating frequency of the proposed geometry is in the range of 3.1 to 10.6 GHz. The proposed compact geometry antenna is applicable for the UWB applications. In order to optimize the dimensions of the antenna, a parametric analysis has been performed. The measured S11 magnitude is less than -10 dB over the band, and it has an impedance bandwidth of 10.60 GHz. The designed UWB antenna gives maximum radiation efficiency and gain of 96.5% and 3.30 dBi, respectively. Also, it gives good time-domain characteristics over the entire resonating band. The designed UWB antenna is simple geometry, and it is applicable for numerous wireless applications.
The Effects of Physical Load and Clamping Force on Prolonged Wearing of AR Glasses

The wearing comfort of augmented reality (AR) glasses is of great importance to achieve prolonged and immersive experience. This study proposed an evaluation method for long-term wearing comfort of AR glasses. A frame prototype that can adjust the frame width smoothly was designed in this study. The effects of physical loads (30g, 45g, 60g, 75g) and clamping forces (0.3N, 0.6N, 0.9,N 1.2N, 1.5N) on subjective discomfort were also investigated. The results show a linear relationship between subjective discomfort, added physical load and increasing clamping force within an hour. It was found that the inflection point of subjective discomfort occurred when the physical load on the nose was 60g and the clamping force on the headside was 1.2N.
Application Progress of Modified Chitosan and Its Composite Biomaterials for Bone Tissue Engineering

In recent years, bone tissue engineering (BTE), as a multidisciplinary field, has shown considerable promise in replacing traditional treatment modalities (i.e., autografts, allografts, and xenografts). Since bone is such a complex and dynamic structure, the construction of bone tissue composite materials has become an attractive strategy to guide bone growth and regeneration. Chitosan and its derivatives have been promising vehicles for BTE owing to their unique physical and chemical properties. With intrinsic physicochemical characteristics and closeness to the extracellular matrix of bones, chitosan-based composite scaffolds have been proved to be a promising candidate for providing successful bone regeneration and defect repair capacity. Advances in chitosan-based scaffolds for BTE have produced efficient and efficacious bio-properties via material structural design and different modifications. Efforts have been put into the modification of chitosan to overcome its limitations, including insolubility in water, faster depolymerization in the body, and blood incompatibility. Herein, we discuss the various modification methods of chitosan that expand its fields of application, which would pave the way for future applied research in biomedical innovation and regenerative medicine.
Improvement of the Solubility and Dissolution Characteristics of Risperidone via Nanosuspension Formulations

Risperidone is an atypical antipsychotic drug that is used for treating schizophrenia, bipolar mania, and autism. Risperidone rebalances dopamine and serotonin to improve thinking, mood, and behavior by working on dopamine and serotonin α2receptor antagonism. Risperidone has poor solubility and high permeability through the intestine, so it belongs to Biopharmaceutical Classification System (BCS) class II exhibits poor oral biopharmaceutical properties. The aim of the present work was to improve solubility and dissolution of Risperidone by preparing nanosuspension using different stabilizers and different solvents‎ in a method known as solvent-antisolvent precipitation method. Twenty-eight formulas were prepared and evaluated particle size, PDI, (EE), zeta potential, and in-vitro dissolution studies. The results showed that particle size of nanosuspension was nanosized for all formulations. The best formula (F13) has particle size (40.9) nm containing a (Soluplus) as a stabilizer in ratio 1:1 with drug by using acetone as a solvent in ratio 1:5 with water which was act as anti-solvent with stirring speed 1000 rpm and E.E % was 98%. For self-dispersible dry nanosuspension, the selected formula (F13) shown fast dispersibility of less than 1 min. and complete in-vitro dissolution to about 30 min. in 0.1N HCl. XRD and DSC indicate the transformation of a crystalline form of risperidone into an amorphous form. The stability studies of the best formula (F13) suggest that estimated shelf life was about 4 years. In conclusion; the formulation of poorly water-soluble risperidone as nanosuspension significantly improved the dissolution rate of drug and enhanced its solubility.
Automatic assessment of posture deviations in assembly tasks

The aim of this study is to investigate the development and the evaluation of a computer vision-based framework to aid the automatic assessment of posture deviations in assembly tasks in realistic work environments. A posture deviation refers to a time-varying working posture performed by the worker, that deviates from ergonomically safe body postures expected in the context of particular work tasks and is known to impose increased physical strain. The estimation of their occurrences can serve as indicators, known as risk factors, for the assessment of physical ergonomics towards the prevention of physical strain and in the-long-term of work-related musculo-skeletal disorders (WMSD). Using visual information acquired by camera sensors, our goal is to estimate the full body motion of a line worker in 3D space, unobtrusively, and to perform classification of four types of posture deviations, also noted as ergonomically sub-optimal working postures that were employed by the MURI risk analysis tool. We formulate a learning-based action classification task using Deep Graph-based Neural Networks and differential temporal alignment cost as a classification measure to estimate the type and risk level of the observed posture deviation during work activities. To evaluate the efficiency of the proposed approach, a new video dataset was captured in the context of the sustAGE project, that demonstrate two different workers during car door assembly actions in a simulated production line in an actual workplace. Rich annotation data were provided by experts in manufacturing and ergonomics. Both quantitative and qualitative evaluation of the proposed framework provide evidence for its efficiency and reliability in supporting ergonomic risk assessment and preventive actions for WMSD in real working environments.
Enrichment Methods for Murine Liver Non-Parenchymal Cells Differentially Affect Their Immunophenotype and Responsiveness towards Stimulation

Hepatocytes comprise the majority of the liver and largely exert metabolic functions, whereas non-parenchymal cells (NPCs)—comprising Kupffer cells, dendritic cells and liver sinusoidal endothelial cells—control the immunological state within this organ. Here, we compared the suitability of two isolation methods for murine liver NPCs. Liver perfusion (LP) with collagenase/DNase I applied via the portal vein leads to efficient liver digestion, whereas the modified liver dissociation (LD) method combines mechanical dissociation of the retrieved organ with enzymatic degradation of the extracellular matrix. In cases of both LP and LD, NPCs were enriched by subsequent gradient density centrifugation. Our results indicate that LP and LD are largely comparable with regards to the yield, purity, and composition of liver NPCs. However, LD-enriched liver NPCs displayed a higher degree of activation after overnight cultivation, and accordingly were less responsive towards stimulation with toll-like receptor ligands that are frequently used as adjuvants, e.g., in nano-vaccines. We conclude that LP is more suitable for obtaining liver NPCs for subsequent in vitro studies, whereas LD as the less laborious method, is more convenient for parallel isolation of larger numbers of samples for ex vivo analysis.
Self-initiated practices in the urban community of Balteiro: Design challenges in a post-pandemic setting

This project aims to identify, document, interpret and disseminate current self-regulated community practices in social housing neighborhoods in the city of Vila Nova de Gaia, Portugal, in 2021. The main, specific case study is the neighborhood of Balteiro. We present methodologies and the first outcomes of the ethnographic work developed at Balteiro, namely an analysis of the origins, dynamics, needs and current challenges in face of post-pandemic scenarios in the present and future of two local initiatives: Associação Recreativa Clube Balteiro Jovem (ARCBJ) and (School Workshop of cartoning and sewing (Escola Oficina); additionally, it presents a first set of hypotheses on how Design may contribute to the resonance of these initiatives in other, equivalent similar social contexts.We argue that COVID-19 pandemic regulations, as well as their economic consequences, have had a significant impact on the nature and viability of the aforementioned practices: as a consequence of social distancing and a phobia of the collective, long periods of lockdown and a radical emptying of public space, prior models of creative communal practice will need re-assessing and re-invention.In turn, the proposal to document and disseminate these practices through Design aims to strengthen the mechanisms of empathy and social solidarity among citizens. The research intends to branch out into intuitive, practical and structural issues: preliminary work has been carried out with the Vila Nova de Gaia City Council and the aforementioned residents' associations ARCBJ and Escola Oficina. Emic data is being collected through methods of direct and indirect observation, including ethnographic interviews, focus groups, and participant observation. Audiovisual and photographic content will be collected towards a bank of resources for further scrutiny and employment in exploratory approaches. The research is therefore aimed at providing strategic outcomes, future replication, contextual adaptation and upscaling to national and international contexts. Inner dynamics in these neighborhoods have always tended to be suspicious of external presence and influence, often relying on self-initiated community practices: sports, recreational and cultural activities and professional training in crafts, examples of successful autonomous processes of civic development throughout the years. This contrasts with the broader socio-cultural context of Portugal, where the norm points towards a reliance on institutional tutelage.This traditional reliance has become an issue in the current scenario of a global pandemic: citizens have witnessed the evidence that former socio-cultural practices may come to struggle in current and emerging scenarios. As such, there is an inevitability in enquiring on the nature, purpose, viability and impact of self-initiated community activities in a post-COVID scenario. Furthermore: can we mediate this socio-cultural reconfiguration on a local scale, towards a broader, networked process of regeneration?
Lightweight Design of Variable-Stiffness Cylinders with Reduced Imperfection Sensitivity Enabled by Continuous Tow Shearing and Machine Learning

The present study investigates how to apply continuous tow shearing (CTS) in a manufacturable design parameterization to obtain reduced imperfection sensitivity in lightweight, cylindrical shell designs. The asymptotic nonlinear method developed by Koiter is applied to predict the post-buckled stiffness, whose index is constrained to be positive in the optimal design, together with a minimum design load. The performance of three machine learning methods, namely, Support Vector Machine, Kriging, and Random Forest, are compared as drivers to the optimization towards lightweight designs. The new methodology consists of contributions in the areas of problem modeling, the selection of machine learning strategies, and an optimization formulation that results in optimal designs around the compromise frontier between mass and stiffness. The proposed ML-based framework proved to be able to solve the inverse problem for which a target design load is given as input, returning as output lightweight designs with reduced imperfection sensitivity. The results obtained are compatible with the existing literature where hoop-oriented reinforcements were added to obtain reduced imperfection sensitivity in composite cylinders.
Novel Insight into the Potential Role of Acylglycerophosphate Acyltransferases Family Members on Triacylglycerols Synthesis in Buffalo

Acylglycerophosphate acyltransferases (AGPATs) are the rate-limiting enzymes for the de novo pathway of triacylglycerols (TAG) synthesis. Although AGPATs have been extensively explored by evolution, expression and functional studies, little is known on functional characterization of how many members of the AGPAT family are involved in TAG synthesis and their impact on the cell proliferation and apoptosis. Here, 13 AGPAT genes in buffalo were identified, of which 12 AGPAT gene pairs were orthologous between buffalo and cattle. Comparative transcriptomic analysis and real-time quantitative reverse transcription PCR (qRT-PCR) further showed that both AGPAT1 and AGPAT6 were highly expressed in milk samples of buffalo and cattle during lactation. Knockdown of AGPAT1 or AGPAT6 significantly decreased the TAG content of buffalo mammary epithelial cells (BuMECs) and bovine mammary epithelial cells (BoMECs) by regulating lipogenic gene expression (p < 0.05). Knockdown of AGPAT1 or AGPAT6 inhibited proliferation and apoptosis of BuMECs through the expression of marker genes associated with the proliferation and apoptosis (p < 0.05). Our data confirmed that both AGPAT1 and AGPAT6 could regulate TAG synthesis and growth of mammary epithelial cells in buffalo. These findings will have important implications for understanding the role of the AGPAT gene in buffalo milk performance.
The hospitalization experience design using gamification applied to a pediatric 3d scanner for compound fractures

Physical, social and mental well-being is the basic assumption which allows children to experience hospitalization positively. In this age of medical-scientific progress and technological development on hospital equipment, the designers of instruments for healthcare focus their activities on developing a coherent patient-centered approach which aims to consider the person globally. Currently, the rigors of the humanization of pediatric care are elaborating products which have both technological innovation and effective design specifications on children’s implicit needs and expectations. Mainly, the active, collaborative, and coordinated presence and accessibility of the family and of the pediatric patient in the care setting are unachieved goals in this field. The article presents the research project Oplà, a 3D acquisition system, as a demonstration of how emerging technologies, culture, communication and collaboration can help significantly in mapping out new diversification measures in standard clinical practice, to enhance the assistance services, by adopting a Human-centered approach strengthened by the iterative process of design thinking.
Clinical Features and Outcomes of Community-Acquired Pneumonia Caused by Haemophilus Influenza

Received 12 November 2020; editorial decision 8 December 2020; accepted 7 April 2021. Correspondence: Daniel M. Musher, MD, Infectious Disease Section, Room 4B-370, VA Medical Center, Houston, TX 77030 (daniel.musher@va.gov). Open Forum Infectious Diseases2021 © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/ by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com DOI: 10.1093/ofid/ofaa622 Clinical Features and Outcomes of Community-Acquired Pneumonia Caused by Haemophilus Influenza