Miracle-dz/UniFAR-FTUs huggingface dataset:
Status Quo and Trends of Intra-Arterial Therapy for Brain Tumors: A Bibliometric and Clinical Trials Analysis

Intra-arterial drug delivery circumvents the first-pass effect and is believed to increase both efficacy and tolerability of primary and metastatic brain tumor therapy. The aim of this update is to report on pertinent articles and clinical trials to better understand the research landscape to date and future directions. Elsevier’s Scopus and ClinicalTrials.gov databases were reviewed in August 2021 for all possible articles and clinical trials of intra-arterial drug injection as a treatment strategy for brain tumors. Entries were screened against predefined selection criteria and various parameters were summarized. Twenty clinical trials and 271 articles satisfied all inclusion criteria. In terms of articles, 201 (74%) were primarily clinical and 70 (26%) were basic science, published in a total of 120 different journals. Median values were: publication year, 1986 (range, 1962–2021); citation count, 15 (range, 0–607); number of authors, 5 (range, 1–18). Pertaining to clinical trials, 9 (45%) were phase 1 trials, with median expected start and completion years in 2011 (range, 1998–2019) and 2022 (range, 2008–2025), respectively. Only one (5%) trial has reported results to date. Glioma was the most common tumor indication reported in both articles (68%) and trials (75%). There were 215 (79%) articles investigating chemotherapy, while 13 (65%) trials evaluated targeted therapy. Transient blood–brain barrier disruption was the commonest strategy for articles (27%) and trials (60%) to optimize intra-arterial therapy. Articles and trials predominately originated in the United States (50% and 90%, respectively). In this bibliometric and clinical trials analysis, we discuss the current state and trends of intra-arterial therapy for brain tumors. Most articles were clinical, and traditional anti-cancer agents and drug delivery strategies were commonly studied. This was reflected in clinical trials, of which only a single study had reported outcomes. We anticipate future efforts to involve novel therapeutic and procedural strategies based on recent advances in the field.
Understanding grid integration issues at wind farms and solutions using voltage source converter FACTS technology

Typically wind farms are located in remote areas, driven by wind and weather patterns with little analysis given to the existing transmission network in a given location. These locations tend to be weaker portions of the grid, which means they are also much more sensitive to fluctuations in reactive power demand. Driven by ever-increasing profit and margin pressures, wind developers quite often utilize low cost induction machines for their wind generators. The problem is that these machines tend to drain large amounts of VARs from the grid, potentially causing low voltage and/or voltage stability problems for the transmission owner. In addition, today's wind generators are sensitive to voltage transients and frequently trip off line due to these events. This paper examines the use VSC technology to address these issues.
Effect of a viscoelastic admixture on transient vibration in a concrete and steel floor

The typical concrete and steel building structure has very little inherent damping, resulting in a very large Q, a measure of the sharpness of the amplitude response at resonance. Some damping effects are provided through the inertia and friction provided by a building''s full height partitions, hung ceilings, furniture, and suspended ducts and piping. These items have an effect on the very low amplitude vibration that affects sensitive laboratory equipment and the processes used in the microelectronic industry. This paper presents studies of transient vibration of floors in two existing buildings. The floors have been treated by adding a two inch thick concrete topping to the structural floor. This additional layer of concrete was treated by using a viscoelastic damping admixture in place of some of the water used to form the concrete. The admixture can dramatically reduce the Q of concrete from the normal 200 to between 20 and 50, depending on the amount of admixture used per yard of concrete. The measured velocity and frequency of the transient vibration excited by footfalls is compared to the predicted velocity and frequency of the same floor structure without the damping admixture. A formula to predict the peak transient vibration velocity due to footfalls for a concrete floor with a viscoelastic admixture is proposed.
Investigation of the Relationship Between Aggression and Adult Attachment in Healthcare Professionals

Introduction Multiple references to the violent and especially difficult patient have been presented by the international literature. However, there is little literature on the aggressive behaviors of health professionals in their workplaces. The aim of this research is to record and correlate aggression and attachment type data of adult health professionals. Methods The sample includes 192 individuals (43 men and 149 women) health professionals in the private and public sector, aged 20 to 60 years, who were selected by the method of random sampling. The survey was conducted from February 2018 to May 2018. The Greek version of the Aggression Questionnaire and the Greek version of the Revised Experiences in Close Relationships (G-ECR-R) self-report inventory were used and the analysis was performed with the Statistical Package of Social Sciences (SPSS 26) (IBM Corp., Armonk, NY). Results The analysis shows that the dimension of avoidance has a positive correlation with hostility and physical aggression and the dimension of stress has a positive correlation with anger, physical aggression and hostility. It also seems that the stress dimension of the adult attachment contributes significantly positively to the prediction of anger and the stress dimension contributes significantly to the prediction of hostility. The dimension of avoiding adult attachment contributes significantly to the prediction of physical aggression. Conclusions To our knowledge, no studies were found in the literature to examine the relationship between the subscales of aggression and dimensions of attachment. It is important that violence in the workplace is recognized as an underlying occupational risk and not just as a matter of criminal law. Finally, more research is needed to study the phenomenon in order to make it more understandable.
Fabrication of high power InGaAs/AlInGaAs strained SQW lasers on InGaAs ternary substrates

High quality In/sub 0.03/Ga/sub 0.97/As ternary substrates have been fabricated by the liquid encapsulated Czochralski (LEG) technique using a semi-infinite melt approach. Lasers using the AlInGaAs/InGaAs alloy system have been fabricated on the conducting substrates for the first time. Pulsed power of 16.2 W at 40 A have been recorded for devices emitting at 1.03 /spl mu/m. Threshold current densities were 595 A cm/sup -2/ and the characteristic temperatures were 100 K. These data demonstrate the commercial potential of ternary substrate manufacture.
Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13

Cannabidiol, a compound of Cannabis sativa, has been proposed as an alternative treatment of schizophrenia. Preclinical and clinical data have suggested that cannabidiol shares more similarity with atypical antipsychotics than typical, both of which are customarily used to manage schizophrenia symptoms. While oligodendrocytes are known to be relevant targets of antipsychotics, the biochemical knowledge in this regard is still limited. Here we evaluated the molecular pathways modulated by cannabidiol compared to the antipsychotics clozapine (atypical) and haloperidol (typical), additionally evaluating the effects of benztropine, a muscarinic receptor antagonist that displays a protective effect in oligodendrocytes and myelination. For this purpose, we employed nano-chromatography coupled with mass spectrometry to investigate the proteomic response to these drugs both in healthy oligodendrocytic cells and in a cuprizone-based toxicity model, using the human oligodendrocyte precursor cell line MO3.13. Cannabidiol shares similarities of biochemical pathways with clozapine and benztropine, in agreement with other studies that indicated an atypical antipsychotic profile. All drugs tested affected metabolic and gene expression pathways and cannabidiol, benztropine, and clozapine modulated cell proliferation and apoptosis when administered after cuprizone-induced toxicity. These general pathways are associated with cuprizone-induced cytotoxicity in MO3.13 cells, indicating a possible proteomic approach when acting against the toxic effects of cuprizone. In conclusion, although modeling oligodendrocytic cytotoxicity with cuprizone does not represent the entirety of the pathophysiology of oligodendrocyte impairments, these results provide insight into the mechanisms associated with the effects of cannabidiol and antipsychotics against cuprizone toxicity, offering new directions of study for myelin-related processes and deficits.
A Survey of United States Tree Care Companies: Part I - Safety Training and Fatal Accidents

Tree work has a high accident rate compared to many other occupations. News accounts of recent accidents can be easily accessed through the internet, though this may not provide a true picture of the number and types of accidents occurring. U.S. government bureaus and agencies have produced reports citing the number and circumstances of fatal accidents in the profession. The government’s information is obtained from many sources and may not accurately identify types or frequency of these accidents. A survey of the accidents and safety training among tree care companies was conducted using a mail questionnaire based on the Tailored Design Method. The company managers responding to the survey overwhelming identified having trained field workers as very important yet only about two-thirds of their companies conducted any training. The training most often conducted was on aerial lifts, chain saws, and chipper, which was provided by company employees in a field setting. Driver’s training was not part of a formal safety program for most of the companies. Aerial rescue was practiced by about one-fourth of the surveyed companies. The most common fatal accidents involved contact with an electrical conductor followed by being struck by a falling limb. The relative number of fatal accidents by event or exposure in this survey was similar to that identified by two federal government reports on fatal accident in the field.
Using Paid and Free Facebook Methods to Recruit Australian Parents to an Online Survey: An Evaluation (Preprint)

BACKGROUND The prevalence of social media makes it a potential alternative to traditional offline methods of recruiting and engaging participants in health research. Despite burgeoning use and interest, few studies have rigorously evaluated its effectiveness and feasibility in terms of recruitment rates and costs, sample representativeness, and retention. OBJECTIVE This study aimed to determine the feasibility of using Facebook to recruit employed Australian parents to an online survey about managing work and family demands, specifically to examine (1) recruitment rates and costs; (2) sample representativeness, compared with a population-based cohort of parents; and (3) retention, including demographic and health characteristics of parents who returned to complete a follow-up survey 6 weeks later. METHODS Recruitment was conducted using 20 paid Facebook advertising campaigns, supplemented with free advertising approaches such as posts on relevant Facebook pages and requests for professional networks to circulate the survey link via Facebook. Recruitment rates and costs were evaluated using the Checklist for Reporting Results of Internet E-Surveys, including view rate, participation rate, completion rate, cost per consent, and cost per completer. Sample representativeness was evaluated by comparing demographic and outcome variables with a comparable sample from the Longitudinal Study of Australian Children including educational attainment, marital status, country of birth, neighborhood disadvantage, work-family conflict, and psychological distress. Retention was evaluated by comparing the number and demographic characteristics of participants at recruitment and at 6-week follow-up. RESULTS Recruitment strategies together resulted in 6653 clicks on the survey link, from which 5378 parents consented to participate and 4665 (86.74%) completed the survey. Of those who completed the survey, 85.94% (4009/4665) agreed to be recontacted, with 57.79% (2317/4009) completing the follow-up survey (ie, 43.08% [2317/5378] of parents who consented to the initial survey). Paid Facebook advertising recruited nearly 75% of the sample at Aus $2.32 per completed survey (Aus $7969 spent, 3440 surveys completed). Compared with a population-based sample, participants at baseline were more likely to be university educated (P<.001), experience greater work-family conflict (P<.001) and psychological distress (P<.001), and were less likely to be born outside Australia (P<.001) or live in a disadvantaged neighborhood (P<.001). CONCLUSIONS Facebook provided a feasible, rapid method to recruit a large national sample of parents for health research. However, some sample biases were observed and should be considered when recruiting participants via Facebook. Retention of participants at 6- to 8-week follow-up was less than half the initial sample; this may reflect limited ongoing participant engagement for those recruited through social media, compared with face-to-face.
Automated Asphalt Highway Pavement Crack Detection Based on Deformable Single Shot Multi-Box Detector Under a Complex Environment

Pavement cracks are severely affecting highway performance. Thus, implementing high-precision highway pavement crack detection is important for highway maintenance. However, the asphalt highway pavement environment is complex, and different pavement backgrounds are more difficult than others for detecting highway pavement cracks. Interference from road markings and surface repairs also complicate the environments and thus the detection of crack. To reduce interference, we collected many images from different highway pavement backgrounds. We also improved the single shot multi-box detector (SSD) network and proposed a novel network named deformable SSD by adding a deformable convolution to the backbone feature extraction network VGG16. We verified our model using the PASCAL VOC2007 dataset and obtained a mean average precision (mAP) 3.1% higher than that of the original SSD model. We then trained and tested the proposed model using our crack detection dataset. We calculated precision, recall, F1 score, AP, mAP, and FPS to examine the performance of our model. The mAP of all categories in the test data was 85.11% using the proposed model 10.4% and 0.55% more than that of YOLOv4 and the original SSD model, respectively. These findings show that our model outperforms YOLOv4 and the original SSD model and confirm that incorporating a deformable convolution into the SSD network can improve the model’s performance. The proposed model is appropriate for detecting pavement crack categories and locations in complicated environments. It can also provide important technical support for highway maintenance.
Inter-CNT capacitance in mixed CNT bundle interconnects for VLSI circuits

This article presents a realistic inter-carbon nanotube (CNT) electrostatic coupling capacitance and tunnelling conductance model for a mixed CNT bundle. The change of potential across such a bundle necessitates the need to consider the inter-CNT capacitance in the equivalent circuit of CNT interconnects for very large scale integration circuits. The equivalent transmission line circuit model of a unit bundle containing one single-walled CNT (SWCNT) and one multi-walled CNT (MWCNT) has been shown. This new model is then used to calculate the delay induced by the inter-CNT capacitance and tunnelling conductance, which predicts the relative positioning of MW/SWCNTs in mixed CNT bundle.
Web based interface to SCADA system

Users working in different departments in an electric power company need access to SCADA data. The problem is to provide access to SCADA data from the various locations in the company at low cost and in a secure way. An intranet and SCADA system interconnection based on industry-accepted communication standards is presented as a solution. Through a link to SCADA data acquisition and control server, a Web server from the intranet brings SCADA real-time and historical information to users via a single front end, the familiar Web browser. The presented solution provides an information layer that is independent of the operating system, lowers hardware, software and administrative costs while improving reliability and security. Through a link to the Internet, SCADA information access can be provided anywhere in the world.
Retrieving stuck liners, tubing, casing, and drillpipe with vibratory resonant techniques

This paper discusses the constructive use of resonant power transmission down the axial length of a stuck oilfield tubular for the purpose of extracting the tubular from inadvertent (e.g., stuck drillpipe or tubing) or purposeful (e.g., gravel-packed liners) confinement. Resonant and nonresonant oilfield systems are examined with appropriate field measurements of resonant parameters.
Book Review: Cannabinoids and Neuropsychiatric Disorders

Despite being quite well-studied, cannabis may be one of the most poorly understood compounds in molecular neuropsychiatry and pharmacology. This is partially due to the diverse behavioral effects of its constituent compounds themselves, the non-selective nature of the exogenous cannabinoids, and the legal hurdles affecting research outputs. The widespread use of marijuana for medical purposes (a complex mixture of over 400 chemical constituents found in widely varying quantities) rather than pure, isolated compounds also complicates the dissection of potential therapeutic applications. The book “cannabinoids and neuropsychiatric disorders” (Murillo-Rodriguez et al., 2021) provides an in-depth exploration of cannabis, its constituent molecules, and synthetic variants—as well as their effects on various psychiatric conditions. It provides the reader with a comprehensive introduction to the complex composition of C. sativa L. and our current understanding of the pharmacological actions of its constituent compounds (as well as the endogenous cannabinoids and synthetic products). It is a useful read for anyone with an interest in the psychopharmacology of medical cannabis, researchers, and healthcare practitioners alike.
Shuttle remote manipulator system hardware test facility

The shuttle remote manipulator (RMS) is designed and built for operations in a zero gravity environment. As such, the ground test facility for the integrated RMS must simulate conditions which support verification of the overall system performance. In order to allow ground test operations, a test facility was constructed with an area of 60 ft. x 120 ft. and extremely tight tolerances on floor flatness and slope. An air bearing support structure was designed for the RMS to operate with 4 degrees of freedom. The RMS system test facility and systems tests conducted to date are described.
Poor Sleep and Decision-Making Disturbance Are Associated With Suicidal Ideation in Pre-natal Depression

Although many risk factors for suicidal ideation have been identified, few studies have focused on suicidal ideation and pre-natal depression. The purpose was to investigate the relationship between decision-making (DM) dysfunction and sleep disturbance on suicidal ideation in pre-natal depression. Participants included 100 women in the third trimester of pregnancy, including pregnant women with pre-natal depression who had recent suicidal ideation (n = 30), pre-natal depression without SI (n = 35) and healthy controls (n = 35). The Iowa Gambling Task (IGT) was used to evaluate the DM function and the Pittsburgh Sleep Quality Index (PSQI) was used to assess the sleep index. The Edinburgh Post-natal Depression Scale (EPDS) was used to assess suicidal ideation and the seriousness of depression. Overall, the two groups with pre-natal depression showed worse sleep quality and decreased DM function compared with healthy controls. The pre-natal depression with suicidal ideation group showed a significantly higher score in subjective sleep quality and a lower score in block 5 of IGT than the pre-natal depression without suicidal ideation group. Further correlation analysis showed that suicidal ideation positively correlated with subjective sleep quality, sleep duration, and daytime function, and negatively correlated with IGT scores. Sleep disturbance and impaired DM function may be risk factors for suicidal ideation in pre-natal depression.
Verifiable Homomorphic Encrypted Computations for Cloud Computing

Cloud computing is becoming an essential part of computing, especially for enterprises. As the need for cloud computing increases, the need for cloud data privacy, confidentially, and integrity are also becoming essential. Among potential solutions, homomorphic encryption can provide the needed privacy and confidentiality. Unlike traditional cryptosystem, homomorphic encryption allows computation delegation to the cloud provider while the data is in its encrypted form. Unfortunately, the solution is still lacking in data integrity. While on the cloud, there is a possibility that valid homomorphically encrypted data beings swapped with other valid homomorphically encrypted data. This paper proposes a verification scheme based on the modular residue to validate homomorphic encryption computation over integer finite field to be used in cloud computing so that data confidentiality, privacy, and data integrity can be enforced during an outsourced computation. The performance of the proposed scheme varied based on the underlying cryptosystems used. However, based on the tested cryptosystems, the scheme has 1.5% storage overhead and a computational overhead that can be configured to work below 1%. Such overhead is an acceptable trade-off for verifying cloud computation which is highly needed in cloud computing. Keywords—Cloud computing; computation verification; data confidentiality; data integrity; data privacy; distributed processing; homomorphic encryption
Performance analyses of a fixed-pitch straight-bladed VAWT with selected low Reynolds number airfoils

One of the most important factors for cost-effective SB-VAWT product is the selection of an appropriate airfoil to achieve desired aerodynamic performance and to optimise the overall dimensions of the SB-VAWT. Design changes related to airfoil also have the potential for increasing the cost effectiveness of SB-VAWTs. This research aims to perform a detailed performance analysis on a series of low Reynolds number (RN) airfoils selected to enhance the performance of smaller capacity fixed-pitch SB-VAWT. Three low RN airfoils have been selected as candidates for the blades of a smaller-capacity SB-VAWT. The research compares their performances with that of a conventionally used symmetric NACA 0015 airfoil. It was found that all candidate low RN airfoils produced higher torque than the NACA 0015 at lower tip speed ratios.