Miracle-dz/UniFAR-FTUs huggingface dataset:
Functional analysis of epithelium-specific Ets transcription factor-1 in inflammation

E26 transformation-specific (Ets) transcription factors are key regulators of hematopoiesis, tissue differentiation, and development, characterized by the presence of evolutionarily conserved DNAbinding domain (DBD) which recognizes a core 5’-GGAA/T-3’ sequence in promoter and enhancer regions of target genes. Epithelium-specific Ets transcription factor-1 (ESE-1), or E74like factor 3 (Elf3) in mice, is a member of the Ets protein family which is known to be constitutively expressed in epithelial tissues. However, ESE-1 is highly and rapidly induced in non-epithelial cells such as endothelial cells, macrophages, and fibroblasts by pro-inflammatory cytokines, despite its lack of expression under resting conditions in these cell types. ESE-1 is also prominently expressed in various human inflammatory diseases including rheumatoid arthritis and vasculitis, and is known to regulate important genes involved in inflammation such as cyclooxygenase-2 (COX-2). Therefore, previous studies have focused on identifying the role of ESE-1 in inflammation using various cell lines and transfection tools as well as an ESE-1 knockout mouse model, which led to discovery of its many target genes and transcriptional regulation by nuclear factor kappa B (NF-B), the central regulator of inflammation. To further enhance our understanding of ESE-1 in human inflammatory diseases, we hereby investigated the ESE-1 expression and function in human primary cells derived from patients suffering from sepsis or
Exploring the Relevance of Financial Literacy Education in a First Nation Community

The relevance of financial literacy education (FLE) in a remote Canadian First Nation community was explored after a generic FLE workshop failed to gain traction. To understand the relevance of FLE in the Community, group interviews, a Community Summit and field notes were used as sources of evidence. During the analysis phase practice theory was use to examine the ‘sayings’, ‘doings’ and ‘relatings’ in a financial context. Next, we examined the possibilities of what can be achieved in the Community and find that site based and Community developed FLE was desired. Reported in this paper are the planning and initiating stages of site based education that occurred.
Gendered Meanings of Leadership: Developing Leadership Through Experiential Community-Based Mentoring in College

Background: Employers consider strong leadership skills among highly desirable qualities for new hires. To meet the needs of today’s complex workforce, colleges and universities have increased opportunities for experiential learning for students. However, it is not known how students make meaning of these experiences in context with their personal backgrounds and experiences. Purpose: This study examines how women and men in college make meaning of leadership and leaders through experiential community-based mentoring participation. Methodology/Approach: A two-step qualitative content analysis of reflective journals, with a sample of 20 students utilizing the constant comparative method, is used to generate overarching themes. A second qualitative analysis compares how men and women understand leadership differently. Findings/Conclusions: Findings reveal that, despite a shift in the leadership literature away from hierarchical or trait models toward transformational, relational models that are typically more inclusive of women, our participants still made meaning of leadership and leaders in ways that were more closely aligned with antiquated understandings of leadership. Implications: Recommendations including use of experiential learning as a tool to intentionally increase leadership development and efficacy for women and men in college are discussed.
Adapting a telephone support intervention to address depression in older adults with HIV

ABSTRACT Rates of depression in older people with HIV range as high as 63%, compared to 15% in the general older adult U.S. population. We tested an adaptation of the RESPECT intervention for its feasibility in addressing depression among older adults with HIV (N = 25). RESPECT involves weekly phone calls made by care managers who engage and listen to the participants, and help to identify needed resources. Over the 6-month study period, depressive symptoms were significantly reduced. Qualitative analyses elucidated the participants’ complex behavioral health problems as well as the supportive nature of phone intervention. Implications for practice are explored.
Absenteeism among Saudi Medical Students

Background: Student absenteeism refers to the frequent absence from classes without any good reason and thought to be the primary concern in health profession education worldwide mainly in medical school. Methods and Material: This study is a cross sectional design conducted in 152 medical students of King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), Saudi Arabia. A self-reported questionnaire was used to determine absenteeism behavior, contributing factors of absenteeism, and level of satisfaction of medical students towards the medical program of the university. Adapted questionnaire from Timmins and Kaliszer (9) was also utilized to examine factors of stress among medical students. Descriptive statistics, linear correlation and Pearson correlational coefficient utilizing SPSS v22 for the analysis of data. Results: A total of 143 (92.76%) participated in the study. 104 or 72 % were male, and 28% were female with mean age of 22.5 (±2.02) and a mean GPA of 4.4 (±0.4). 77 (53.8%) of students were absent for 5 times or more in lectures/basic and clinical sciences sessions and clinical diagnostic sessions. These absences are mainly because of study (n=36, 25.2%) and course dissatisfaction (n=32, 22.4%). However, only 3 (2.1%) who had an absence for 5 times or more in Problem Based Learning (PBL) sessions. These absences in PBL sessions are mainly because of sleep (n=11, 7.7%) and family commitments (n=10, 7.0%). There is an inverse correlation between absenteeism and academic performance. Conclusion: Absenteeism has a negative impact on the academic performance of medical students.
Sub-quadratic time for riemann-roch spaces: case of smooth divisors over nodal plane projective curves

We revisit the seminal Brill-Noether algorithm in the rather generic situation of smooth divisors over a nodal plane projective curve. Our approach takes advantage of fast algorithms for polynomials and structured matrices. We reach sub-quadratic time for computing a basis of a Riemann-Roch space. This improves upon previously known complexity bounds.
New Insights in the Design of Nanoparticles Entrapping Diclofenac

Nanoparticles have a special place in nanoscience and nanotechnology, not only because of their particular properties resulting from their reduced dimensions, but also because they are promising building blocks for more complex nanostructures. Diclofenac is an anti-inflammatory drug that inhibits cyclooxygenase (COX)-2 enzyme with greater potency than COX-1 does. The adverse effects can occur when NSAIDs are used for a long time, leading to gastrointestinal and renal dysfunctions. Nanoparticles of diclofenac are nanotransporters that facilitate the intracellular penetration and can reduce the side-effects of uncorporated diclofenac. Nanoparticles incorporating diclofenac have been made using various polymers and different stabilizers. The most important parameters in the characterization of nano-systems are the particle size and their size distribution in the colloidal solution, the Zeta potential, the polymorphism, the crystallization level, the degree of drug loading and its release profile.
Leveraging Python to Process Cross-Cultural Temperament Interviews: A Novel Platform for Text Analysis

During childhood, parents represent the most commonly used source of their child’s temperament information and, typically, do so by responding to questionnaires. Despite their wide-ranging applications, interviews present notorious data reduction challenges, as quantification of narratives has proven to be a labor-intensive process. However, for the purposes of this study, the labor-intensive nature may have conferred distinct advantages. The present study represents a demonstration project aimed at leveraging emerging technologies for this purpose. Specifically, we used Python natural language processing capabilities to analyze semistructured temperament interviews conducted with U.S. and German mothers of toddlers, expecting to identify differences between these two samples in the frequency of words used to describe individual differences, along with some similarities. Two different word lists were used: (a) a set of German personality words and (b) temperament-related words extracted from the Early Childhood Behavior Questionnaire (ECBQ). Analyses using the German trait word demonstrated that mothers from Germany described their toddlers as significantly more “cheerful” and “careful” compared with U.S. caregivers. According to U.S. mothers, their children were more “independent,” “emotional,” and “timid. ” For the ECBQ analysis, German mothers described their children as “calm” and “careful” more often than U.S. mothers. U.S. mothers, however, referred to their children as “upset,” “happy,” and “frustrated” more frequently than German caregivers. The Python code developed herein illustrates this software as a viable research tool for cross-cultural investigations.
Adults and children engaging with ePortfolios in an early childhood education setting

While common across the primary, secondary and tertiary sectors of education, ePortfolios are relatively new in the early childhood education sector, nationally and internationally. They are, however, becoming more widespread in Aotearoa New Zealand as a platform to present children’s formative assessment documentation. There is very little documented evidence of the use of ePortfolios in early childhood education (ECE) and as such little is known about how they could impact on parent and whānau [1] engagement with their children’s learning; teachers’ formative assessment practices; how they contribute to children’s learning journeys and indeed how children could use ePortfolios. This study located in Aotearoa New Zealand investigated the use of ePortfolios in an early childhood education setting and how teachers, parents, whānau and children engaged with them, in comparison to their engagement with paper- based portfolios. The ECE setting involved in this research was using paper-based portfolios as artefacts to document children’s development and learning over time, and had been doing so for several years prior to the research being undertaken. The setting had a history of robust documentation but struggled to find ways that enabled parents and whānau to contribute to this documentation in a written form. After a period of investigation into the use of paper-based portfolios, and their effectiveness in encouraging parents and whānau to contribute, ePortfolios were introduced. Accordingly this research presents a comparative study of paper-based portfolios and ePortfolios. After the introduction of ePortfolios, significant changes were evident in the ways that parents, whānau and teachers engaged with the learning documentation contained in the ePortfolios. Changes were also evident in the teachers’ formative assessment practices and in the ECE setting’s community of practice, which at the onset of the research was just developing. Consequently, the research underlined the importance of portfolios, in whatever format, as artefacts which encourage children, their families and teachers to revisit their learning—allowing for support and extension of the learning. This thesis presents these findings and discusses the implications for practice and policy. [1] Whānau means family in the language of the indigenous people of Aotearoa New Zealand – Māori.
Identifying the Roles of Research Entities in Technological Knowledge Flow Among Patents Assignees by Using Patent Citations

Despite much research on the interdisciplinarity of the publications across subject categories, few studies analyze the interdisciplinarity of the technological knowledge flow among research entities (i.e., patent assignees, inventors, and countries). In this article, we propose a framework to identify the roles of the research entities by measuring the interdisciplinarity of the technological knowledge flow. Research entities are positioned on the two-dimensional maps based on the integration index, diffusion index, and specialization index, which are used to measure the degree of the interdisciplinarity of different research entities in knowledge flow. In order to explore the role of the research entities in knowledge flow, we put forward four kinds of research entities: diverse knowledge provider, active mediator of diverse knowledge flow, diverse knowledge consumer, and negative mediator of diverse knowledge flow. The case study related to synthetic biology indicates that this method is valid and could explore effectively, the roles of the research entities to further guide the creation of new inventions by converging prominent technologies beyond technology field boundaries in facilitating active technology flow and support technological competitive evaluation and policy decision-making.
Biochemical and molecular studies on effect of polymer seed coating of soybean

The present study was conducted at the Research Farm Adhartal, Department of Plant Breeding and Genetics, JNKVV, Jabalpur (M.P.) during Kharif season of 2016-17. Research experiment was laid out in a Randomized block design with five replications and four treatments i.e T0 No treatment or (Water + Thiram), T1- Polymer seed coating (Disco AG SP Red L-200) + Thiram + Carboxine, T2- Polymer seed coating (Disco AG SP Red L-200) + Thiram + Genius coat, T3- Polymer seed coating (Disco AG SP Red L-200) + Thiram + Mycorhiza comprised of soybean genotype JS JS 20-29. Five plants were randomly selected from each treatment and replications for Phenological and Physiological Parameters. Maximum protein % was registered in Treatments Polymer seed coating (Disco AG SP Red L-200) + Thiram + Genius coat (T2) (40.64), Treatments T3 (20.04) possessed the maximum fat % and showed differed significantly among them. The DNA amplification pattern revealed that a total number of 42 RAPD loci were amplified with an average of 7.0 loci per RAPD primer comprising 30 polymorphic loci (71.43%) and 12 monomorphic loci (28.57 %). The range of polymorphism was 50 % (OPA-01&OPA 02) to 89.0 % (OPA 07). Amplified product (band) size ranged from 300 bp (OPA-03) to 2800 bp (OPA-05). The no of bands ranged from 04 (OPA-02) to 09 (OPA -07).
QUINTUPLE-MODE WIDEBAND SUBSTRATE INTEGRATED WAVEGUIDE FILTER WITH ELLIPTIC DIELECTRIC LOADING

This paper presents a novel quintuple-mode wideband filter based on a circular Substrate Integrated Waveguide (SIW) cavity. To implement this filter, a pair of two metallic perturbation vias loaded around the diameter resonator line is used. An Elliptic Dielectric Resonator (EDR) was introduced in the middle of the cavity to shift certain resonant modes and restrain the higher-order modes. The optimal dimensions and dielectric permittivity of the EDR are investigated. A single SIW resonator filter has been designed, manufactured, and measured as an experimental example to verify the proposed design. Simulation and measurement results agree with 51.7% of fractional bandwidth at 10.1 GHz central frequency, with one transmission zero (TZ) at the lower frequency side and four TZs at the upper side.
Facing our shadows: understanding harm in the arts therapies

ABSTRACT This paper examines what harm reveals about psychoactive power in the arts therapies. A 20-year sample of fitness-to-practise cases brought to the UK statutory regulator (the Health and Care and Professions Council) was examined to establish the prevalence of practitioners who cause harm which was low (0.165%). Transcripts of sanctioned cases were used to construct a grounded theory of how harm is mediated in arts therapies practice. This revealed service users enter arts therapies with damaged self-trust in the expectation that they can trust the professional. In non-harmful therapy, trust in the professional is then used to boost self-trust in the service user. In arts therapies practice, the arts create powerfully emotionally salient elements to aid therapy which can affect both service user and arts therapists’ attachment systems to fulfil this task. Harm was enacted when the arts therapist used the power of that trust to isolate the relationship and introduce their own needs through arts therapies practices. This increased service user dependency on the arts therapist and further decreased their self-trust resulting in harm. Harm was only possible where the arts therapist’s self-reflection failed and they distorted theory to self-justify their actions and refute all feedback to the contrary. Plain language summary This paper examines harm in the arts therapies (art, drama and music therapies as regulated by the Health and Care Professions Council (HCPC)). Harm is understudied but important because it tells us how things can go wrong and also indicates where areas of strong psychoactive power may operate in therapy which can also help people. Arts therapies have been regulated by the HCPC for 20 years and we found there were 77 cases brought against arts therapies practitioners with a total of 16 cases that led to HCPC sanction. We used a grounded theory method of analysis to try to understand how harm was mediated in those harmful arts therapy practices because it is an established form of qualitative research used to construct a theory of social action using examples drawn from real-world examples. We found that service users enter arts therapies with damaged self-trust in the expectation that they can trust the professional. In non-harmful therapy, trust in the professional is then used to boost self-trust in the service user. Within arts therapies, the arts support access to powerful emotions which underpins the building of trust, an element essential to good therapy. However, harm happened when the arts therapist used the power of that trust to isolate the relationship, introduced personal issues and used the service user for their own needs. This increased service user dependency on the arts therapist, detrimentally affecting their sense of self-trust and resulting in harm. Harm was only possible where the arts therapists’ self-reflection failed and they distorted theory to self-justify their actions and refute all feedback to the contrary.
‘Kindness isn’t important, we need to be scared’: disruptions to the praxis of peace education in an Indian school

ABSTRACT There is a dearth of research on the frustrations, moral dilemmas and challenges non-Western teachers might face in the everyday praxis of peace education. To address this gap, this study analyses how violence is negotiated and understood in an Indian school seeking to build a culture of peace. Interviews with eight teachers and four students are analysed using grounded theory. Firstly, the study discusses a teacher’s response to a student witnessing domestic violence. Thereby, it explores the limits of peace education in the face of home-school boundaries and societal stigmas. Secondly, the study discusses a teacher’s attempt to help an abused child labourer. It questions the extent to which peace education can tackle systemic inequalities and the danger of the field reproducing exclusionary structures. Thirdly, the study discusses the intergenerational politics of children endorsing corporal punishment. It seeks to demonstrate how socio-economic pressures and historical legacies might lead to children legitimating violence against their own bodies. By exploring the fractures and gaps within peace education in an understudied non-Western context, the study aims to raise larger questions about the structures and norms hindering ideals of peace and the need for peace education to prioritise criticality, context and reflexivity.
Evaluation of laryngoscopic view, intubation difficulty and sympathetic response during direct laryngoscopy in sniffing position versus simple head extension: a clinical comparative study

Background: Proper position of the head and the neck is important for optimizing laryngoscopic view and for ease of endotracheal intubation.We compared two different positions, sniffing position and simple head extension during direct laryngoscopy on the basis of laryngoscopic view, intubation difficulty and sympathetic response. Methodology: One hundred twenty patients of age group 20-50 years, scheduled for elective surgeries under general anaesthesia were divided into two equal groups in a randomized fashion. In group A (n = 60), sniffing position during laryngoscopy and intubation; and in group B(n =60),simple head extension position during laryngoscopy and intubation. Laryngoscopy view, ease of intubation and hemodynamic parameters were recorded. Results: Demographic data and the different parameters for assessment of difficult airway were similar in both groups. Glottic visualization grade was superior in group A and intubation difficulty score were higher in Group B (P < 0.05), Hemodynamic parameters at different time intervals were comparable. Conclusion: Sniffing position during laryngoscopy was found to be superior to simple head extention position in respect of better glottis visualization and ease of intubation though no difference in sympathetic response to intubation was found.
Early Childhood English Language Acquisition of Hausa Children Living in Rural Communities of Kano State Nigeria

This paper examines the problem with early childhood English language acquisition of Hausa children living in rural communities in Kano State in that most of the children who grow up in rural communities do not know and cannot speak English language despite the fact that it’s a medium of communication in their schools. Yet the English variant (pidgin) which they learn to speak in order to be able to communicate with their peers and other members of their society in their environment, cannot be said to ascribe solid competence and performance to them in the English language. The ultimate purpose of this paper therefore, is to look at the early childhood English language acquisition of Hausa children living in rural areas of Kano State and to offer suggestions that could lead to their solution. As a prelude to this, however an attempt is made to examine the theoretical framework of English language: Its meaning, how its generally acquired, its uses in early childhood education and its relationship with culture.