Miracle-dz/UniFAR-FTUs huggingface dataset:
A survey on routing problems and robotic systems

SUMMARY Planning paths that are length or time optimized or both is an age-long problem for which numerous approaches have been proposed with varied degree of success depending on the imposed constraints. Among classical instances in the literature, the Traveling Salesman Problem and the Vehicle Routing Problem have been widely studied and frequently considered in the realm of mobile robotics. Understandably, the classical formulation for such problems do not take into account many different issues that arise in real-world scenarios, such as motion constraints and dynamic environments, commonly found in actual robotic systems, and consequently the solutions have been generalized in several ways. In this work, we present a broad and comprehensive review of the classical works and recent breakthroughs regarding the routing techniques ordinarily used in robotic systems and provide references to the most fundamental works in the literature.
Making Sense of Chinese Employees’ Suicidal Ideation: A Psychological Strain—Life Meaning Model

Using the strain theory of suicide, this study examines how psychological strains influence suicide ideation via the mediating mechanism of the meaning in life. To check the hypothesized model, data were drawn from professional employees (n=687) across six organizations of various business types to increase the variability of respondent perception and the generalizability of the study findings. The results showed significant correlations among psychological strains, meaning in life, and suicide ideation. Furthermore, this study provides evidence for the mediation effect of meaning in life in the relationship between psychological strain and suicide ideation. Implications and future directions are discussed.
Transcranial magnetic stimulation: an alternative physical treatment in depression

There are still a very limited number of physical therapies available for those suffering from depression, in spite of the rapid developments in pharmacological treatments. Electroconvulsive therapy (ECT) has the highest rate of response of any form of antidepressant therapy but is generally used only in those patients failing to respond to pharmacotherapy, except in specific and very limited situations where it is recommended as a primary therapy. Stereotactic subcaudate tractotomy (SST), the standard neurosurgical procedure employed in the UK for resistant depression, is only indicated when patients are suffering from severe, disabling depressive illness; and have failed to respond to all other treatments. Physical therapies are generally framed in this context, ie. as treatments for those suffering from intractable depression. Novel physical therapies will inevitably be compared to ECT as the standard physical treatment. The categorisation and comparison of new physical therapies with ECT may not be the appropriate way to proceed with evaluating the usefulness of such treatments. Transcranial magnetic stimulation (TMS) is a new technology for non-invasively stimulating the brain and may be an example of a treatment option that needs to be re-evaluated outside the context of resistant depression.
Electron Beam-Induced Carbon Erosion and the Impact on Electron Probe Microanalysis

Abstract Electron beam-induced carbon contamination is a balance between simultaneous deposition and erosion processes. Net erosion rates for a 25 nA 3 kV beam can reduce a 5 nm C coating by 20% in 60 s. Measurements were made on C-coated Bi substrates, with coating thicknesses of 5–20 nm, over a range of analysis conditions. Erosion showed a step-like increase with increasing electron flux density. Both the erosion rate and its rate of change increase with decreasing accelerating voltage. As the flux density decreases the rate of change increases more rapidly with decreasing voltage. Time-dependent intensity (TDI) measurements can be used to correct for errors, in both coating and substrate quantifications, resulting from carbon erosion. Uncorrected analyses showed increasing errors in coating thickness with decreasing accelerating voltage. Although the erosion rate was found to be independent of coating thickness this produces an increasing absolute error with decreasing starting thickness, ranging from 1.5% for a 20 nm C coating on Bi at 15 kV to 14% for a 5 nm coating at 3 kV. Errors in Bi Mα measurement are <1% at 5 kV or above but increase rapidly below this, both with decreasing voltage and increasing coating thickness to 20% for a 20 nm coated sample at 3 kV.
Investigating the Link Between Pathological Narcissism and Somatization

Abstract Although the self-image distortions and sensitivities of pathological narcissism have been theorized to contribute to somatization, limited empirical research has been devoted to this issue. The present study was developed to test the hypothesis that pathological narcissism contributes to somatic symptoms through increased hypervigiliance to physical sensations. A community sample of 248 adults completed measures of pathological narcissism, somatosensory amplification, somatic symptoms, and depression. Mediation analysis was conducted, controlling for depression, using 99% bootstrapped confidence intervals to examine the indirect effect of pathological narcissism on somatic symptoms via somatosensory amplification. Although pathological narcissism was not directly related to somatic symptoms, a significant indirect effect was observed for pathological narcissism on somatic symptoms via somatosensory amplification. This finding suggests that pathological narcissism contributes to physical hypersensitivity, in turn influencing perceptions of somatic distress. The role of narcissistic dysfunction in somatization indicates the importance of further research and potential clinical consideration.
Health-Promoting Lifestyle among People Without Heart Disease in Isfahan

Background: The present research conducted with aim to determine the health-promoting behaviors (HPBs) of public of Isfahan, and study the associations of HPBs with demographic characteristics. Methods: In a cross-sectional study conducted on 369 people without heart disease living in Isfahan, HPBs were assessed using a questionnaire which consists of two parts: personal information and Health-Promoting Lifestyle Profile II (HPLP-II). Data were analyzed by t-test and one-way analysis of variance. Results: The mean score for overall HPLP-II (158.30 ± 19.38) indicated the acceptable level of performing HPBs in Isfahan. Physical activity got the lowest score (16.36 ± 5.13), and the highest score was for interpersonal relations (53.16 ± 5.59). There were significant differences on physical activity and interpersonal relation dimensions between males and females (P < 0.05). The mean score of physical activity was highest in single participants (P < 0.05). Mean score of physical activity for people with college education was greater than others (P < 0.05). Overall HPLP-II and its domains mean scores for people that received education about prevention of cardiovascular disease were greater than others (P < 0.05). Conclusions: Results showed HPBs in people of Isfahan society is acceptable but physical activity is in the worst condition. The role of physical activity in preventing and controlling cardiovascular disease is well established. Therefore, it seems that providing information about physical activity can lead to an improvement of health-promoting lifestyle.
Infection and Propagation of Astrovirus VA1 in Cell Culture

Astrovirus VA1/HMO‐C (VA1) is the representative genotype of mamastrovirus 9, a species of the single‐stranded, positive‐sense RNA viral family, Astroviridae. Astroviruses have been traditionally considered pathogens of the gastrointestinal tract but they have been recently associated with neurological diseases in humans, cattle, mink, sheep, and pigs. VA1 is the astrovirus genotype most commonly identified from human cases of meningoencephalitis and has been recently propagated in cell culture. VA1 can now be used as a model system to study pathogenesis of the neurological diseases associated with astrovirus infection. In this article, we describe two fundamental assays to quantify replication and propagation of VA1, a quantitative reverse transcription‐PCR (qRT‐PCR) to measure viral RNA and a 50% tissue culture infectious dose (TCID50) assay to measure infectious viral particles. © 2018 by John Wiley & Sons, Inc.
Effects of Gamma-Irradiation on the Antioxidant Potential of Traditional Bulgarian Teas

Food irradiation technologies are used to reduce the risk of food borne diseases by eliminating pathogenic microorganisms, prolonging shelf life and reducing storage losses by delaying ripening, germination or sprouting. However, application of irradiation in food technology can negatively influence the biologically active compounds in foods. In this research, the effect of gamma-irradiation on the antioxidant activity of Bulgarian teas was investigated. The aim of the study was to evaluate the total phenolic and tannin content and antioxidant activity of ethanolic extracts of Bulgarian herbal teas before and after gamma-irradiation. Mursalski tea (Sideritis scardica), Mashterka tea (Thymus serpyllum), Good Night tea (tea mix), Staroplaninski tea (Balkan tea mix), Trakia tea (tea mix), and Mountain tea (Planinski tea mix) were selected for this study. Gamma-irradiation was applied at the absorbed dose of 5 kGy. Antioxidant activity of non-irradiated and irradiated teas was determined by measuring antiradical activity against DPPH• and ABTS•+ and the ability to reduce ferrous ions. The highest total phenolic content was found in Mursalski tea (268 mg/g), and the highest tannin content in Good Night tea (168 mg/g). FRAP, TEAC and DPPH assays revealed that the most active samples were Staroplaninski (2.78 mmol Fe (II)/g), Planinski (0.87 mmol Trolox/g) and Planinski (0.032 mg/mL), respectively. The radical scavenging activity of irradiated tea samples was maintained after gamma-irradiation. The most interesting extract from irradiated tea studied was Staroplaninski, which demonstrated a higher antioxidant potential in the irradiated sample compared with the non-irradiated sample.
Sex-based differences in speed, sub-technique selection, and kinematic patterns during low- and high-intensity training for classical cross-country skiing

Objectives We investigated sex-based differences in speed, sub-technique selection, and kinematic patterns during low- (LIT) and high-intensity training (HIT) for classical cross-country (XC) skiing across varying terrain. Methods Six male and six female elite XC skiers with an approximately 15% differences in VO2max (men: 68.9±2.9 mL·min-1·kg-1, women: 60.1±3.3 mL·min-1·kg-1) were monitored using a multi-sensor system to collect time-synchronised data of heart rate, speed, and multiple tri-axial inertial measurements units while XC skiing on a 5-km competition track. Results Men skied 21% faster than women during HIT (5.9±0.3 m·s-1 vs. 4.9±0.2 m·s-1, P < .001), with the greatest difference (26%) while skiing on flat terrain, whereas skiing speed did not significantly differ between men and women during LIT. At similar instructed intensity and rating of perceived effort, women exhibited significantly higher relative heart rate (85±2% vs. 71±3% of maximum) and blood lactate levels (4.0±1.3 vs. 1.2±0.2 mmol/L) during LIT (all P < .001) than men, whereas physiological responses did generally not differ between the sexes during HIT. During both intensities and among both sexes, double poling (DP) was the sub-technique most used relative to distance, followed by miscellaneous sub-techniques (MISC), diagonal stride (DIA), kick double poling (DK) and herringbone (HRB). In relation to distance women used DIA more than men during LIT (22% vs. 17%, P = .009) and HIT (23% vs. 12%, P = .001), whereas men used MISC, including tucking and turning, more than women during LIT (39% vs. 25%, P = .017) and HIT (41% vs. 30%, P = .064). In particular, men used DP more than women while skiing the uphill sections during both LIT (24% vs. 11%, P = .015) and HIT (39% vs. 13%, P = .002). Conclusions Our findings provide novel insights into sex-based differences in speed, sub-technique selection, and kinematic patterns during LIT and HIT for classical skiing.
Mediating impact of fan-page engagement on social media connectedness and followers purchase intention

Purpose The purpose of this paper is to identify the mediating effect of fan-page followers’ engagement activities and moderating role of followers’ demographic profile and trust level on their purchase intention. Design/methodology/approach This study utilised the customer engagement behaviour and consumer involvement theory as a foundation to explore the impact of variables. Structural equation modelling was utilised to test the model with the data collected from 307 Facebook fan pages’ followers of five Malaysian companies. Findings It was shown that following fan pages will influence fan page engagement, which in turn affects purchase intention and social media connectedness. Further analysis indicated that the impact of “follow” and “engagement” on purchase intention differs between genders, ages, level of trust and income. Research limitations/implications The study serves as a basic fundamental guideline for academics and researchers to interpret the concept of following fan pages and engagement actions and its effects on purchase intention and social media connectivity, as well as opening a vast area of unexplored researches on the subject of social media. Practical implications The research provides information for business-to-consumer companies in utilising fan page based on user categories. Originality/value This study proposes the application of an empirically tested framework to the fan-page follow actions. The authors argue that this framework can provide a useful foundation for future social commerce research. The results would help academics be aware of fan page and its user’s engagement actions, which will provide a new avenue of research.
Motor system recruitment during action observation: No correlation between mu-rhythm desynchronization and corticospinal excitability

Observing others’ actions desynchronizes electroencephalographic (EEG) rhythms and modulates corticospinal excitability as assessed by transcranial magnetic stimulation (TMS). However, it remains unclear if these measures reflect similar neurofunctional mechanisms at the individual level. In the present study, a within-subject experiment was designed to assess these two neurophysiological indexes and to quantify their mutual correlation. Participants observed reach-to-grasp actions directed towards a small (precision grip) or a large object (power grip). We focused on two specific time points for both EEG and TMS. The first time point (t1) coincided with the maximum hand aperture, i.e. the moment at which a significant modulation of corticospinal excitability is expected. The second (t2), coincided with the EEG resynchronization occurring at the end of the action, i.e. the moment at which a hypothetic minimum for action observation effect is expected. Results showed a Mu rhythm bilateral desynchronization at t1 with differential resynchronization at t2 in the two hemispheres. Beta rhythm was more desynchronized in the left hemisphere at both time points. These EEG differences, however, were not influenced by grip type. Conversely, motor potentials evoked by TMS in an intrinsic hand muscle revealed an interaction effect of grip and time. No significant correlations between Mu/Beta rhythms and motor evoked potentials were found. These findings are discussed considering the spatial and temporal resolution of the two investigated techniques and argue over two alternative explanations: i. each technique provides different measures of the same process or ii. they describe complementary features of the action observation network in humans.
Hyperacute changes in blood mRNA expression profiles of rats after middle cerebral artery occlusion: Towards a stroke time signature

Stroke evolution is a highly dynamic but variable disease which makes clinical decision making difficult. Biomarker discovery programs intended to aid clinical decision making have however largely ignored the rapidity of stroke evolution. We have used gene array technology to determine blood mRNA expression changes over the first day after stroke in rats. Blood samples were collected from 8 male spontaneously hypertensive rats at 0, 1, 2, 3, 6 and 24h post stroke induction by middle cerebral artery occlusion. RNA was extracted from whole blood stabilized in PAXgene tubes and mRNA expression was detected by oligonucleotide Affymetrix microarray. Using a pairwise comparison model, 1932 genes were identified to vary significantly over time (p≤0.5x10-7) within 24h after stroke. Some of the top20 most changed genes are already known to be relevant to the ischemic stroke physiopathology (e.g. Il-1R, Nos2, Prok2). Cluster analysis showed multiple stereotyped and time dependent profiles of gene expression. Direction and rate of change of expression for some profiles varied dramatically during these 24h. Profiles with potential clinical utility including hyper acute or acute transient upregulation (with expression peaking from 2 to 6h after stroke and normalisation by 24h) were identified. We found that blood gene expression varies rapidly and stereotypically after stroke in rats. Previous researchers have often missed the optimum time for biomarker measurement. Temporally overlapping profiles have the potential to provide a biological “stroke clock” able to tell the clinician how far an individual stroke has evolved.
Dominance of international high-risk clones in carbapenemase-producing Pseudomonas aeruginosa: Multicentric molecular epidemiology report from India

Background: Pseudomonas aeruginosa is one of the most common opportunistic pathogens that cause severe infections in humans. The burden of carbapenem resistance is particularly high and is on the rise. Very little information is available on the molecular mechanisms and its clonal types of carbapenem-resistant P. aeruginosa seen in Indian hospitals. This study was undertaken to monitor the β-lactamase profile and to investigate the genetic relatedness of the carbapenemase-producing (CP) P. aeruginosa collected across different hospitals from India. Materials and Methods: A total of 507 non-duplicate, carbapenem-resistant P. aeruginosa isolated from various clinical specimens collected during 2014–2017 across seven Indian hospitals were included. Conventional multiplex polymerase chain reaction for the genes encoding beta-lactamases such as extended-spectrum beta-lactamase (ESBL) and carbapenemase were screened. A subset of isolates (n = 133) of CP P. aeruginosa were genotyped by multilocus sequence typing (MLST) scheme. Results: Of the total 507 isolates, 15%, 40% and 20% were positive for genes encoding ESBLs, carbapenemases and ESBLs + carbapenemases, respectively, whilst 25% were negative for the β-lactamases screened. Amongst the ESBL genes, blaVEB is the most predominant, followed by blaPER and blaTEM, whilst blaVIM and blaNDM were the most predominant carbapenemases seen. However, regional differences were noted in the β-lactamases profile across the study sites. Genotyping by MLST revealed 54 different sequence types (STs). The most common are ST357, ST235, ST233 and ST244. Six clonal complexes were found (CC357, CC235, CC244, CC1047, CC664 and CC308). About 24% of total STs are of novel types and these were found to emerge from the high-risk clones. Conclusion: This is the first large study from India to report the baseline data on the molecular resistance mechanisms and its association with genetic relatedness of CP P. aeruginosa circulating in Indian hospitals. blaVIM- and blaNDM-producing P. aeruginosa is the most prevalent carbapenemase seen in India. Majority of the isolates belongs to the high-risk international clones ST235, ST357 and ST664 which is a concern.
Distributed cooperative deployment of heterogeneous autonomous agents: a Pareto suboptimal approach

SUMMARY The paper presents a distributed cooperative control law for autonomous deployment of a team of heterogeneous agents. Deployment problems deal with the coordination of groups of agents in order to cover one or more assigned areas of the operational space. In particular, we consider a team composed by agents with different dynamics, sensing capabilities, and resources available for the deployment. Sensing heterogeneity is addressed by means of the descriptor function framework, an abstraction that provides a set of mathematical tools for describing both agent sensing capabilities and the desired deployment. A distributed cooperative control law is then formally derived finding a suboptimal solution of a cooperative differential game, where the agents are interested in achieving the requested deployment, while optimizing the resources usage according to their dynamics. The control law effectiveness is proven by theoretical arguments, and supported by numerical simulations.
Physiological and Perceived Exertion Responses during Exercise: Effect of &bgr;-blockade

Purpose This study investigated the effect of &bgr;-blockade on physiological and perceived exertion (RPE) responses during incremental treadmill exercise. Methods Sixteen healthy participants (n = 8 men; age, 25.3 ± 4.6 yr) performed a maximal treadmill exercise test after ingestion of 100 mg metoprolol or placebo, with a double-blind, randomized, and counterbalanced design. Heart rate (HR), ventilatory, and gas exchange variables were measured continuously, and participants reported RPE at the end of each minute. Physiological and RPE responses during each condition were compared at the ventilatory threshold (VT), respiratory compensation point, and at maximal exercise using repeated-measures ANOVA. Linear regression modeled relationships between perceived exertion and physiological variables. Results The HR and V˙O2 at the VT, respiratory compensation point, and maximal exercise were all significantly lower after &bgr;-blockade (P < 0.05). However, when standardized to within condition peak values, differences were no longer significant. The RPE associated with VT was higher after &bgr;-blockade (12.9 ± 1.0 vs 12.3 ± 1.2, P < 0.05) but lower at maximal exercise (19.1 ± 0.6 vs 19.4 ± 0.5, P < 0.05). Increases in RPE relative to HR were greater after &bgr;-blockade and remained significant when expressed relative to peak HR. There was no difference in the growth of the relationship between RPE and V˙O2 across conditions, although the origin of the relationship was higher with &bgr;-blockade. Conclusions Although &bgr;-blockade resulted in a significant reduction in exercising HR and V˙O2, the RPE for a given relative intensity remained unchanged. The relationship between RPE and V˙O2 was not affected by &bgr;-blockade. The results provide evidence that RPE is a useful and reliable measure for exercise testing and prescription in patients prescribed &bgr;-blockade therapy.