Miracle-dz/UniFAR-FTUs huggingface dataset:
MPSoC Simulation and Implementation of KPN Applications

Design of Multiprocessor System-on-a-Chips (MPSoC) currently suffers from poor tool support. MPSoC is considered to be the next general design platform for embedded system designs. As complex designs such as multimedia and gaming processing become more common in handheld devices and traditional ASIC solutions are too slow and too expensive, MPSoC allows a fast software solution by running multiple low-cost, low-speed, low-power embedded processors in parallel and combining their processing power to solve more complex computation problems. However, current design methodologies for MPSoC generally restrict the specification of the software for the convenience that it can be analyzed statically. Such restrictions prevent MPSoC designs to reach their full potentials. In this thesis, I propose an MPSoC design methodology that does not impose unnecessary restrictions on the software. Specifically, Kahn Process Network (KPN) is used to model the applications such that each process in the KPN process networks can be expressed by the full power of high-level programming languages. Unfortunately, allowing the full power of high-level programming languages prevents the software to be analyzed statically. Therefore, similar to optimizing software for single-processor systems, a profile-based methodology is proposed to explore the vast design space of MPSoC for applications written in KPN. There are two main ingredients in the methodology. (1) The MPSoC simulation must be made both fast and accurate. The speed of the simulation must allow designers to modify and experiment different design options in the limited design time allocated for system-level design exploration. At the same time the simulation must be accurate enough for the exploration results to be meaningful. A new MPSoC simulation framework that simulates in the speed close to behavioral simulation and generates performance results with less than 5% error is shown. (2) An analysis from the simulation must provide accurate MPSoC-specific profiling information about the implementation for guiding the designers to make design decisions. Execution characteristics of MPSoC make such profiling information very different from single-processor systems. A new profiling technique specifically to determine performance-critical information for MPSoC is described. Three optimization techniques at various implementation levels that use the proposed methodology are shown and applied to an MPEG-2 Decoder design. The experiments show that the optimization techniques using the methodology can efficiently optimize the implementations in term of performance, power and area. The results show that the methodology allows designers to explore the MPSoC design space more efficiently with the accurate MPSoC profiling information.
More 'cries from the joints': assessment of the musculoskeletal system is poorly documented in routine paediatric clerking.

OBJECTIVES The aim of this study was to describe the assessment of the musculoskeletal (MSK) system in comparison with other systems in routine paediatric medical clerking. Furthermore, to survey trainee paediatricians (SPRs, specialist registrars) about their self-rated confidence in assessing the MSK system. METHODS Case notes of consecutive general paediatric medical patients admitted to three UK hospitals over a 4-week period were assessed using a standard pro forma. All patients had been assessed by a consultant paediatrician during their admission. A postal questionnaire was sent to all SPRs in training in each of the hospitals, regarding their confidence in assessing the MSK system compared with other systems and their exposure to MSK teaching. RESULTS Case notes of 257 patients [117 females, median age 3 yr (range 1-18 yr)] were reviewed. The most common reason for admission was acute infection, although the spectrum of other recorded diagnoses varied between hospitals. Thirteen children (5%) had an acute problem (e.g. infection) against a background of chronic disease. The case note documentation showed that cardiovascular (CVS), respiratory (RS) and gastrointestinal (GI) systems were assessed in the vast majority (>90%) of patients, irrespective of the underlying diagnosis. However, other systems were less well recorded; the trend being the same in each hospital and in descending order, the neurological system (38%), skin (32%), eyes (10%) and musculoskeletal system (4%). Only 2.7% (7/257) patients were documented to have been asked about MSK symptoms, and only 1.6% (4/257) had any documentation of joint examination--in all cases this was limited (e.g. range of movement of the knee only), and no patients had documentation of gait being examined, even in those children presenting with 'limp'. The response rate to the postal questionnaire was 60% (67/112). The self-rated confidence in MSK assessment was markedly low in comparison with other systems, even though 61/67 recalled some teaching of the MSK system as an undergraduate (61/67) or postgraduate (50/67). Of note none could recall teaching as an undergraduate in paediatric MSK assessment and where there had been postgraduate rheumatology MSK teaching this had been delivered by paediatric rheumatologists in many cases (34/50), reflecting the centres participating in the study. CONCLUSIONS In routine general paediatric medical in-patient clerking and throughout the admission, MSK assessment was rarely documented, and even where present was limited. This contrasts markedly with other systems which were examined in most children irrespective of the presenting complaint. Self-rated confidence in MSK assessment is low amongst SPRs compared with other systems, despite most recalling some teaching. This discrepancy between teaching and clinical practice needs to be addressed in undergraduate and postgraduate training.
The Effect of Wind Farms on Residential Property Values in Lee County, Illinois

Lee County, Illinois experienced significant wind energy development over the last decade. The county is home to the first commercial wind farm constructed in Illinois, which began operation in November of 2003. Additional wind farms began operating in April of 2007 and December of 2009. Although the County has been living with wind development for several years, there is still debate about its effect on residential property values. This study utilizes a hedonic price model to assess the impacts on 1,298 real estate transactions from 1998 to 2010. The analysis indicates that residential properties located near wind turbines in Lee County have not been affected by their presence.
Large homogeneous mono-/bi-layer graphene on 6H–SiC(0 0 0 1) and buffer layer elimination

In this paper we discuss and review results of recent studies of epitaxial growth of graphene on silicon carbide. The presentation is focused on high quality, large and uniform layer graphene growth on the SiC(0 0 0 1) surface and the results of using different growth techniques and parameters are compared. This is an important subject because access to high-quality graphene sheets on a suitable substrate plays a crucial role for future electronics applications involving patterning. Different techniques used to characterize the graphene grown are summarized. We moreover show that atomic hydrogen exposures can convert a monolayer graphene sample on SiC(0 0 0 1) to bi-layer graphene without the carbon buffer layer. Thus, a new process to prepare large, homogeneous stable bi-layer graphene sheets on SiC(0 0 0 1) is presented. The process is shown to be reversible and should be very attractive for various applications, including hydrogen storage.
Involvement of the Nand C-terminal domains of Mycobacterium tuberculosis KatG in the protection of mutant Escherichia coli against DNA-damaging agents

3 Department o f The Mycobacterium tuberculosis KatG enzyme, like most hydroperoxidase I (HPI)-type catalases, consists of two related domains, each with strong similarity to the yeast cytochrome c peroxidase. The catalase-peroxidase activity is associated with the amino-terminal domain but currently no definite function has been assigned to the carboxy-terminal domain, although it may play a role in substrate binding. This paper reports another possible function of the KatG protein involving protection of the host cell against DNAdamaging agents. The M. tuberculosis katG gene, the 5' domain and the 3' domain were cloned separately, in-frame with the maltose-binding protein, into the vector pMALc2. These constructs were introduced into four DNArepair mutants of Escherichia coli, DK1 ( red) , AB1884 (uvrC), A61885 (uvrf3) and AB1886 (uvrA), which were then tested for their ability to survive treatment with UV light (254 nm), hydrogen peroxide (1.6 mg ml-l) and mitomycin C (6 pg ml-l). Al l three constructs conferred resistance to UV upon the r e d E. coli cells, whereas resistance to mitomycin C was found in all repair mutants tested. Protection against hydrogen peroxide damage was less pronounced and predominantly found in the r e d host. These results indicated that the M. tuberculosis katG gene can enhance DNA repair in E. coli, and that the 5' and 3' domains can function separately. UV sensitivity tests on Mycobacterium intracellulare and M. tuberculosis strains mutant in katG revealed that the katG gene product does not play an additive role in the survival of mycobacterial cells after exposure to short-wavelength UV irradiation, in repair-competent cells.
Lack of Serotype Antigen in A. actinomycetemcomitans

Aggregatibacter actinomycetemcomitans is divided into 6 serotypes. Occurrence of non-serotypeable strains is known, but background reasons are unclear. We hypothesized that non-serotypeable strains represent new serotypes or have altered expression of serotype-specific polysaccharide antigen (S-PA). We first characterized 311 strains from 189 individuals using both immunoassay- and PCR-based serotyping. Next, using natural human infection and rabbit immunization approaches, we clarified whether the phenotypically non-serotypeable strains expressed S-PA. Immunoassay identified serotypes a–f among 216 strains from 159 individuals. The remaining 95 strains from 30 individuals were phenotypically non-serotypeable. Yet, all these strains were identified by PCR-typing as serotype a-, b-, c-, or f. Non-serotypeability was confirmed by Western immunoblot with respective rabbit antisera. Patient sera remained non-reactive with autologous non-serotypeable strains at the serotype-specific region. Rabbit immunization with a phenotypically non-serotypeable strain induced no antibody production against S-PA. Thus, phenotypically non-serotypeable strains did not include novel serotypes, but lacked S-PA expression.
Defects in mitochondrial distribution during the prolonged lag phase of Saccharomyces cerevisiae preceding growth in glycerol as the sole source of carbon.

The Saccharomyces cerevisiae strain CBS6412 has been shown to be able to grow in synthetic medium containing glycerol as the sole carbon source, conditions under which laboratory strains such as CEN.PK and S288c cannot grow. Nonetheless, this strain exhibits a lag phase of c. 30-40 h following transition to glycerol medium. As mitochondria play a critical role in the dissimilation of the respiratory carbon source glycerol, we investigated mitochondrial function and dynamics throughout the lag phase using mitochondria-targeted roGFP, a redox-sensitive GFP variant. We found that following transition to glycerol medium, mitochondria become more oxidizing, accumulate near the bud neck, and exhibit decreased inheritance into daughter cells. Directly preceding entry into exponential growth phase, mitochondria become more reducing, mitochondrial accumulations at the bud neck decrease, and inheritance of mitochondria into daughter cells is restored.
MOT by using scientific methodology in Samsung R&D

The article consists of a Powerpoint presentation on MOT by using scientific methodology in Samsung R&D. The areas discussed include: technology roadmap (TR) process; single point forecasting & scenario planning; strategic technology roadmap; R&D project roadmap development; technology tree; usefulness of TRIZ in Samsung R&D; six sigma methodology; etc
VSC-Based HVDC Power Transmission Systems: An Overview

The ever increasing progress of high-voltage high-power fully controlled semiconductor technology continues to have a significant impact on the development of advanced power electronic apparatus used to support optimized operations and efficient management of electrical grids, which, in many cases, are fully or partially deregulated networks. Developments advance both the HVDC power transmission and the flexible ac transmission system technologies. In this paper, an overview of the recent advances in the area of voltage-source converter (VSC) HVdc technology is provided. Selected key multilevel converter topologies are presented. Control and modeling methods are discussed. A list of VSC-based HVdc installations worldwide is included. It is confirmed that the continuous development of power electronics presents cost-effective opportunities for the utilities to exploit, and HVdc remains a key technology. In particular, VSC-HVdc can address not only conventional network issues such as bulk power transmission, asynchronous network interconnections, back-to-back ac system linking, and voltage/stability support to mention a few, but also niche markets such as the integration of large-scale renewable energy sources with the grid and most recently large onshore/offshore wind farms.
Proton energy dependence of the light output in gallium nitride light emitting diodes

Gallium nitride (GaN)-based blue-emitting diodes (CREE Model C430-DH85) were irradiated at room temperature with protons in the energy range 2 to 115 MeV at fluences varying from 1/spl times/10/sup 11/ to 1/spl times/10/sup 15/ cm/sup -2/. Light output degradation curves were obtained for each energy and the damage constant (A) associated with these curves was determined according to the theory of Rose and Barnes. For proton energies less than 10 MeV, A varies inversely with the proton energy (E). At higher energies, A is consistently above the 1/E relationship. The change in nature of the energy dependence is attributed to nuclear interactions. Nonionizing energy loss calculations for the case of protons on GaN are presented. Good agreement between theory and experiment is obtained.
Integration of scientific experimental data through ontology approach: a review

Data integration in scientific experiments is important to the scientists in many research domains. This is because many experimental data involved multidiscipline areas and run in different machines or instruments which results in data stored in different ends and human intervention is required in forming a chain of data analysis. Ontology is one of the approaches that have been used in data integration in many domain areas. This paper described and reviewed ontology in data integration effort. Furthermore, the state of research for ontology-based integration of scientific experiment data also covered in this paper.
P13, an Integral Membrane Protein of Borrelia burgdorferi, Is C-Terminally Processed and Contains Surface-Exposed Domains

ABSTRACT To elucidate antigens present on the bacterial surface ofBorrelia burgdorferi sensu lato that may be involved in pathogenesis, we characterized a protein, P13, with an apparent molecular mass of 13 kDa. The protein was immunogenic and was expressed in large amounts during in vitro cultivation compared to other known antigens. An immunofluorescence assay, immunoelectron microscopy, and protease sensitivity assays indicated that P13 is surface exposed. The deduced sequence of the P13 peptide revealed a possible signal peptidase type I cleavage site, and computer analysis predicted that P13 is an integral membrane protein with three transmembrane-spanning domains. Mass spectrometry, in vitro translation, and N- and C-terminal amino acid sequencing analyses indicated that P13 was posttranslationally processed at both ends and modified by an unknown mechanism. Furthermore, p13 belongs to a gene family with five additional members in B. burgdorferi sensu stricto. The p13 gene is located on the linear chromosome of the bacterium, in contrast to five paralogous genes, which are located on extrachromosomal plasmids. The size of the p13 transcript was consistent with a monocistronic transcript. This new gene family may be involved in functions that are specific for this spirochete and its pathogenesis.
Selection in reference to biological groups. I. Individual and group selection applied to populations of unordered groups.

A selection theory designed to accommodate interactions among genotypes is presented. This involves defining unordered groups of genotypes among which interactions may occur, and describing populations of groups generated as combinatorial products of base populations. Gene models are developed which consist not only of direct contributions of the genotypes they represent but also of associate effects from other genotypes in the group.
EBV lytic infection enhances transformation of B‐lymphocytes infected with EBV in the presence of T‐lymphocytes

Epstein–Barr virus (EBV) establishes lifelong latency in B‐lymphocytes following infection. Although in immune‐competent individuals EBV remains in a quiescent state, in immunodeficient individuals, such as those with AIDS or transplant recipients, B‐lymphocytes infected with EBV proliferate to give rise to lymphoproliferative diseases. Similarly, in vitro, EBV transforms human B‐lymphocytes into indefinitely growing lymphoblastoid cell lines (LCLs) in the absence of cytotoxic T‐lymphocytes. Although LCLs harbor the entire EBV genome as an episome, in most cells the virus remains in a latent state expressing a fraction of EBV genes, and lytic infection occurs spontaneously but only in a small percentage of cells. Here, we report that lytic infection contributes to EBV‐induced lymphoproliferation by a paracrine mechanism. An EBV immediate‐early protein, BZLF1, induces IL‐13, thus facilitating the proliferation of EBV‐transformed B‐lymphocytes in the presence of T‐lymphocytes. These data suggest that lytic gene products could contribute to virus‐induced oncogenesis by a paracrine mechanism. J. Med. Virol. 84:504–510, 2012. © 2011 Wiley Periodicals, Inc.
ASPECTS OF LYMPHOCYTE FUNCTION IN MYASTHENIA GRAVIS *

Immunologic abnormalities in myasthenia gravis have been the focus of much attention since the early 1960s. As is evident from the number of papers related to clinical and experimental immunology in this volume, the role of the immune system in myasthenia gravis is still a promising area of research into the pathogenesis of this disorder. Immunologic abnormalities reported in the past in myasthenia gravis have included (1) the presence of antibodies to muscle structural proteins 1-4 and more recently, to muscle acetylcholine receptors 5 9 6 ; (2) evidence both for and against immunodeficiency 7-11; ( 3 ) the presence of immunologic activity, against muscle,12-14 thymus,13 and acetylcholine receptor,l5 in the peripheral blood 12, 13, and thymic cells 14 as measured by presumptive in vitro parameters and (4) immunogenetic analysis relating myasthenia to HL-A types.lg, 2o Earlier papers and other reports in this symposium are directed at reexamining some of these controversial areas using various immunologic methods for analysis. In addition, the association of myasthenia with some other putative autoimmune diseases 21-2~$ and autoantibodies 4, 22 is fairly well accepted. Our studies have been related to immunologic analysis of thymic lymphocytes since the thymus is histologically abnormal in many patients with myasthenia gravis.24 Previous immunologic studies of the thymus by others have shown conflicting findings with regard to the comparative degree of in vitro proliferative responses of thymic lymphocytes (TL) of myasthenics and controls to mitogens thought to stimulate predominately T (thymic-dependent) lymphocytes [phytohemagglutinin (PHA) or Concanavalin A (Con 25 Others have reported TL cell mediated immunity to muscle as manifested by (1) the
A survey on secure gateway discovery in MANET

Mobile adhoc network (MANET) is a collection of mobile node that can communicate with each other via radio or infra without any fixed infrastructure. MANET is a wireless network so to connect with internet any interface is needed that is called gateway which provide route to the internet. Due to dynamic topology packets are loss which degrades network operation. So to achieved high throughput security scheme are applied on internet gateway which helps to out from adversarial environment. There are some security goal is discussed (confidentiality, integrity, authentication and non-repudiation) which enhanced adhoc network operation. In this paper we survey on the gateway discovery scheme with security and without security on the basis of various performance parameter like packet delivery ratio, end to end delay, routing overhead and throughput and then conclude which one is better.
Breathing is Not An Option; Dyspnea is

Idiopathic pulmonary fibrosis (IpF) is the most common idiopathic interstitial pneumonia. It is a progressive, fibrotic, incurable disease with a survival time of two to three years (1). the current guidelines place emphasis on early integrated palliative care and a symptom-based approach (1, 2). Dyspnea is the most debilitating symptom of all advanced lung diseases, including IpF (3). patients frequently end up using emergency services as a point of care (4, 5). there is an urgent need for a comprehensive, integrated care delivery program that includes: physician support; detailed dyspnea action plans, including selfmanaged, home-based crisis action plans; and reassessment of goals of care (6). there is a significant knowledge gap in dyspnea management that leads to inadequate and inappropriate treatment in advanced cases (7). Most end-stage patients are not referred to palliative care, and most clinicians are not well versed in symptombased management (8, 9). opioids are used orally, subcutaneously, or intravenously to treat refractory dyspnea (9). to our knowledge, there are no published reports describing the use of sublingual fentanyl in dyspneic patients with IpF in conjunction with optimization of supplemental oxygen therapy and individualized home pulmonary rehabilitation programming. We report our approach to assessment and management of dyspnea using a collaborative, rehabilitative, and palliative approach.
Acrylic cranioplasty using miniplate struts.

OBJECTIVE Cranioplasty using acrylic is a common procedure in patients with cranial defects secondary to trauma, infection, or tumor. The limitations of this technique include poor adherence of the acrylic to surrounding bone and difficulty in achieving a proper cosmetic contour in complicated cranial defects, especially those involving the orbital rim. The authors have been continually developing techniques of cranioplasty. METHODS Ten consecutive cranioplasties were performed over the past 5 years using this new technique. TECHNIQUE The authors describe a technique using miniplates as struts to which the acrylic is applied using a "reinforced concrete" principle. RESULTS/CONCLUSION All patients achieved excellent cosmetic results with no complications. This technique allows contour of the repair site while the acrylic is curing and provides a more resilient resulting prosthesis.