Miracle-dz/UniFAR-FTUs huggingface dataset:
Lipid membranes trigger misfolding and self-assembly of amyloid β 42 protein into aggregates

The assembly of polypeptides and proteins into nanoscale aggregates is a phenomenon observed in a vast majority of proteins. Importantly, aggregation of amyloid β (Aβ) proteins is considered as a major cause for the development of Alzheimer’s disease. The process depends on various conditions and typical test-tube experiments require high protein concentration that complicates the translation of results obtained in vitro to understanding the aggregation process in vivo. Here we demonstrate that Aβ42 monomers at the membrane bilayer are capable of self-assembling into aggregates at physiologically low concentrations, and the membrane in this aggregation process plays a role of a catalyst. We applied all-atom molecular dynamics to demonstrate that the interaction with the membrane surface dramatically changes the conformation of Aβ42 protein. As a result, the misfolded Aβ42 rapidly assembles into dimers, trimers and tetramers, so the on-surface aggregation is the mechanism by which amyloid oligomers are produced and spread.
The analgesic evaluation of gabapentin for arthroscopy: a meta-analysis of randomized controlled trials

Introduction: The efficacy of gabapentin for pain management of arthroscopy remains controversial. We conduct a systematic review and meta-analysis to explore the influence of gabapentin versus placebo on the postoperative pain intensity of arthroscopy. Methods We search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through April 2020 for randomized controlled trials (RCTs) assessing the effect of gabapentin versus placebo on pain control of arthroscopy. This meta-analysis is performed using the random-effect model. Results Five RCTs are included in the meta-analysis. Overall, compared with control group for arthroscopy, gabapentin remarkably decreases pain scores at 24 h (Std. MD=-0.68; 95% CI=-1.15 to -0.02; P = 0.21), analgesic consumption (Std. MD=-18.24; 95% CI=-24.61 to -11.88; P < 0.00001), nausea and vomiting (OR = 0.42; 95% CI = 0.21 to 0.84; P = 0.01), but has no obvious influence on pain scores at 6 h (Std. MD=-1.30; 95% CI=-2.92 to 0.31; P = 0.11) or dizziness (OR = 1.12; 95% CI = 0.56 to 2.24; P = 0.75). Conclusions Gabapentin is effective for pain control after arthroscopy.
Multi-objective optimal thyristor controlled series compensator installation strategy for transmission system loadability enhancement

Owing to the continuously increased electricity demands and power transactions, power systems are becoming more vulnerable to insecurity, generally incurred by overutilised transmission facilities or any contingency. In order for existing transmission networks to accommodate more power transfers with less network expansion cost, proper installation of thyristor controlled series compensator (TCSC) is validated to be one of the most `promising options'. The multi-objective optimal TCSC installation strategy proposed in the study first applies the performance index sensitivity factor technique to investigate which lines are most necessary for TCSC installation and with the lines specified for TCSC installation and the multi-objective function consisting of maximum system loadability and minimum TCSC installation cost, the problem to determine the capacity for each TCSC installation is then formulated as a multi-objective optimisation problem and solved by using the fitness sharing multi-objective particle swarm optimisation method. Finally, in the Pareto front set obtained, the solution with the TCSC installations that can make the power system provide the required loadability with biggest utilisation index value is recommended. The modified IEEE-14 buses, IEEE-118 buses systems and a practical power system are used to validate the performance of the proposed method.
A Vacuum Four-Ball Tribometer to Evaluate Liquid Lubricants for Space Applications

The design and operation of a vacuum tribometer, based on a four-ball configuration, is described. This tribometer evaluates the tribological characteristics of liquid lubricants for space applications. Operating conditions were room temperature, loads to 1000N, speeds to 500 rpm, and pressures of 10{sup -6} Pa. Tests could also be run at atmospheric pressure with air or nitrogen. Some typical test results are included. 13 refs., 8 figs.
Enhancing forest fires preparedness in Portugal: the relevance of integrating risk communication with community engagement and development

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Development of adaptive algorithms for the operation of windows, fans, and doors to predict thermal comfort and energy use in Pakistani buildings

This year-round field investigation of the use of building controls (windows, doors and fans) in 33 Pakistani offices and commercial buildings focuses on 1) how the occupants' behavior is related to thermal comfort, 2) how people modify the indoor environment and 3) how we can predict the occupants' behavior. We have found that the use of building controls depends on climate and season. The use of these controls has a cooling effect on the occupant through increasing the air movement or the ventilation. The behavioral model yields adaptive algorithms that can be applied in building thermal simulations to predict the effects of the occupants' behavior on energy-saving building design.
Acceptance Measurement of Health Insurance Information System Based on Technology Acceptance Model

The objective of this research is to evaluate P-Care BPJS information system based on Technology Acceptance Model (TAM). The type of research is analytical, cross sectional approach. Number of respondents 206 P-Care BPJS users at primary health care. Data analysis using linear regression. Based on correlation test external variables with percieved usefulness, showed high correlation = 0.6 (p <0.001); external variables with percieved ease of use showed moderate correlation = 0.4 (p <0.001); perceived ease of use with attitude showed moderate correlation = 0.5 (p <0.001); percieved usefulness with attitude showed high correlation = 0.7 (p <0.001); perceived usefulness with actual use showed moderate correlation = 0.5 (p <0.001); behavioral intention to use with percieved usefulness showed moderate correlation = 0.5 (p <0.001); attitude with behavioral intention to use showed high correlation = 0.6 (p <0.001); behavioral intention to use with actual use showed high correlation = 0.7 (p <0.001).
Wavelet Neural Network-based Wind-power Forecasting in Economic Dispatch: A Differential Evolution, Bacterial Foraging Technology, and Primal Dual-interior Point Approach

Abstract Wind speed and wind-power generation are characterized by their inherent variability and uncertainty. To overcome this drawback, an accurate prediction of wind speed is essential. The purpose of this paper is to develop a hybrid wavelet neural network model for wind-speed forecasting and thus, in turn, for wind-power generation. The combined optimal economic scheduling of the wind generators and conventional generators has also been investigated in this paper. The solution methods, namely primal dual interior point, differential evolution, and bacterial foraging technology, are used for solving the wind-thermal economic dispatch (ED). The feasibility of the proposed algorithms is demonstrated on three-unit, 13-unit, and 40-unit systems and their performances are compared in terms of the generation cost and execution time. The results show that the proposed algorithms are indeed capable of handling ED problems.
Chua's Circuit: A Paradigm for Chaos

Strange attractors and dynamical models, L.P. Shil'nikov from the Chua circuit to the generalized Chua map, R. Brown bispectral analysis of Chua's circuit, S. Elgar and M.P. Kennedy sound and music from Chua's low-level visual sensing, E.J. Altman chaos synchronization in Chua's circuit, L.O. Chua et al controlling chaos in Chua's circuit, G.A. Johnson et al controlling of chaos in the driven Chua's circuit, K. Murali and M. Lakshmanan controlling Chua's circuit, G-R. Chen and X-N. Dong distortion control of chaotic systems - the Chua's circuit, R. Genesio and A. Tesi control of Chua's circuit, T. Hartley and F. Mossayebi reconstructing the dynamics of Chua's circuit, J. Glover and A. Mees travelling wavefront and its failure in a one-dimensional array of Chua's circuit, V. Perez-Munuzuri et al n-dimensional canonical Chua's circuit, Lj Kocarev et al. (Part contents).
FE Simulation of Torque and Drag inside Borehole of Oil and Gas Wells (Part II)

The wellbore friction, torque and drag, between drill string and the wellbore wall is the most important issue which limits the drilling industry to go beyond a certain measured depth.The calculation and analysis of torque and drag were considered to be very important in drilling and well design. A variety of models (soft, stiffness, mixed and finite element) have been used to determine the torque and drag. A FEA (Finite Element Analysis) model of the drill string to simulate it’s working behavior, involving contacts between the drillstring and borehole wall was developed, this FE Model was to be compared with computational model of torque and drag, and to be verified with experimental results.The drillstring displacements calculated by the FEA model matches those from commercial software in petroleum industry (Landmark). The model developed and discussed in this paper can be used for predicting torque and drag inside wellbores of oil and gas wells, and it will also benefit in preplanning simulation of oil and gas well drilling operations.
Electromagnetic interference of power conditioners for solar electric propulsion

Electrical, multikilowatt power conditioning (PC) equipment needed on board a spacecraft utilizing solar electric propulsion creates an electromagnetic environment that is potentially deterimental to the science, navigation, and radio communication hardware. Within the scope of the solar electric propulsion system technology program, three lightweight, 2.5-kW PCs were evaluated in terms of their electromagnetic characteristics. It was found that the levels of radiated and conducted interference exceeded the levels anticipated for a solar electric propulsion mission. These noise emissions, however, were the result of deficient interference design in these models, rather than a basic inability to control interference in this type of PC.
Determination of the patients and management of their nutritional therapies with a new algorithm and a new multidisciplinary team for dysphagia

Many studies have shown that the nutritional status of patients significantly affects the prognosis of treatment. The term dysphagia is used to describe swallowing disorders in clinical trials. This is the most difficult group about the ways in which nutritional treatment should be given to the patients who have functional gastrointestinal system but have the risk of aspiration due to dysphagia and blurred consciousness. A new algorithm has been developed to help clinicians make nutritional treatment decisions in this patient group in accordance with the experience of the Dysphagia Unit operating in our hospital since May 2017. The basic objective of the algorithm is to supply all nutritional needs of patients with dysphagia by minimal invasive procedures, minimal risk of infection, and minimal complication.
SISTEM INFORMASI MONITORING INVENTORI BARANG PADA BALAI RISET STANDARDISASI INDUSTRI BANDAR LAMPUNG

Industry Research and Standardization Bandar Lampung or shortened by Industry Baristand a Government agency under the Ministry of Industry which was established in 1975, is engaged in the research , mastery of technology , testing for food products , agro- industry, as well as technical training in order to support the growth of industrial sector in Lampung province. However, there are still many obstacles that arise and the absence of inventory monitoring system special items resulting in invalid data items due to lack of information which supports the above data processing. Center for Standardization and Industrial Research of Bandar Lampung need to do a good evaluation of the data by monitoring information system to control the inventory items borrowing and returning items through inventory monitoring. Monitoring information system of goods inventory will be made ​​of a system development. Keywords: Monitoring inventory, Information Systems
Compact dual-band-notched UWB planar monopole antenna with modified SRR

To prevent interference problems due to existing nearby communication systems within an ultra-wideband (UWB) operating frequency, a compact dual-band-notched UWB antenna is presented. This antenna consists of a trapezoidal ground plane with a rectangle slot, a Y-shaped monopole used as the radiator, together with a modified complementary co-directional splitering resonator (SRR) etched on the radiation patch, which leads to the desired dual notched bands for lower and upper bands of the WLAN. Experimental results show that the designed antenna, with compact size of 24×25×mm, has a wide bandwidth covering 3.05-14.2 GHz, realising dual notched bands of 5.14-5.36 and 5.74-6.07 GHz.
Wavelet-based algorithm for voltage flicker analysis

Fourier transform-based algorithms have been popular for voltage flicker analysis; however, their accuracy is unfavorably influenced by the leakage effect. This paper presents a wavelet-based algorithm for voltage flicker analysis. The algorithm can accurately extract the voltage flicker components by the direct demodulation of the voltage signal. The performance characteristics of the algorithm are evaluated with examples of appropriate simulated and field data. The results illustrate the proposed algorithm is free of leakage effect problems.
Dealing with crisis : a comparative study of simulation exercises in Korea and the UK

The thesis aims to examine simulation exercises comparatively in Korea and the UK, and provide practical suggestions for the future of Korean simulation exercises, based on lessons from the UK experiences and practices, regarding effective planning and execution of simulation exercises. To achieve this aim, two research questions were formulated. Firstly, ‘How are simulation exercises in Korea and the UK organised and conducted, and how can this knowledge be used to respond to crises or disasters more effectively? ’. Secondly, ‘Why are new methodological changes to organise and conduct simulation exercises needed in Korea? ’. In order to practically assess whether or not simulation exercises in Korea are sufficient in dealing with the nature and characteristics of a large-scale disaster, this thesis carries out an in-depth investigation of two real-life underground fires: the King’s Cross Underground Fire in the UK and the Daegu Subway Fire in Korea. Simulation exercises are influenced by the social, political, and cultural contexts of emergency management arrangements, and hence, the study also conducts a comparative study of emergency management frameworks in Korea and the UK. The current practices of simulation exercises in Korea can be categorised into the four main themes: ‘Top-level Commitment and Support’, ‘Repeating Training through Rehearsals’, ‘The Politics of Box Seats, Ill-structured Scenario-Scripts and a Lack of Adaptation’, and ‘The Politics of Podium and Speech-based Debriefs’. However, critical analysis of the empirical data in the study reveals that a complex and highly-coupled ‘socio-technical’ crisis does not respect such a conventional training and exercising methodology of Korean simulation exercises, and that a degree of ‘adaptation’ is indispensable to effective crisis response. Thus, it is proposed in the study that Korean simulation exercises need to allow adaptation and diversion to take place, encouraging communication and discussion between exercise players. Furthermore, ensuing afteraction reviews in Korea should be transformed into a discussion-based debriefing style to maximise learning effectiveness. Finally, it is suggested that emergency management arrangements in Korea should also evolve into a more flexible, decentralised, bottom-up model in terms of effective response to ‘socio-technical’ crises or disasters along with changes in simulation exercises and subsequent after-action reviews.
Perspectives on External Support to Low Level Private Health Facilities in Management of Childhood Infections in Mbarara District, Uganda: A Qualitative Study With Health Workers and Policy Makers

Background: With the under-five child mortality rate of 46.4 deaths per 1000 live births, Uganda needs to accelerate measures to reduce child deaths in order to achieve the Sustainable Development Goal 3. While 60-70 % of frontline health services are provided by the private sector, many low level private health facilities are unregistered, unregulated, and often miss out on innovative strategies rolled out by the Ministry of Health. Low level private health facilities need support in order to provide quality health care. We explored the perspectives of health workers and policy makers on external support given to low level private clinics providing health care for children. Methods: In-depth interviews were conducted from May to December 2019 with 43 purposively selected key informants. They included 30 health care professionals treating children in low level private clinics and 13 policy makers from Mbarara district and the Uganda Ministry of Health directly involved with ensuring quality of child health. The issues discussed included their views on the quantity, quality, factors determining support received and preferred modalities of support to low level private health facilities. Using an inductive approach, interview transcripts were coded to identify categories and themes. ﻿Results: We identified three themes which emerged from the data 1) External support is needed to address socio-economic, regulatory and knowledge gap issues, 2) Current support is not optimal, and, 3) Ideal support underscores working together. While the Ministry of Health recognises its’ responsibility to provide support and guidance to public and private health facilities, it acknowledges lack of support for low level private health facilities currently. Health providers emphasised technical capacity building and more supportive supervisory visits but not simply policing and apportioning blame.Conclusion: The current support being given to low level private health facilities (LLPHF) is inadequate. The support needs to be tailored to the needs of the facility and health facilities have to proactively ask for support. Capacity building with emphasis on training and supportive supervision are key strategies for providing external support to LLPHF.
Functional tests of the competitive exclusion hypothesis for multituberculate extinction

Multituberculate mammals thrived during the Mesozoic, but their diversity declined from the mid-late Paleocene onwards, becoming extinct in the late Eocene. The radiation of superficially similar, eutherian rodents has been linked to multituberculate extinction through competitive exclusion. However, characteristics providing rodents with a supposed competitive advantage are currently unknown and comparative functional tests between the two groups are lacking. Here, a multifaceted approach to craniomandibular biomechanics was taken to test the hypothesis that superior skull function made rodents more effective competitors. Digital models of the skulls of four extant rodents and the Upper Cretaceous multituberculate Kryptobaatar were constructed and used (i) in finite-element analysis to study feeding-induced stresses, (ii) to calculate metrics of bite force production and (iii) to determine mechanical resistances to bending and torsional forces. Rodents exhibit higher craniomandibular stresses and lower resistances to bending and torsion than the multituberculate, apparently refuting the competitive exclusion hypothesis. However, rodents optimize bite force production at the expense of higher skull stress and we argue that this is likely to have been more functionally and selectively important. Our results therefore provide the first functional lines of evidence for potential reasons behind the decline of multituberculates in the changing environments of the Paleogene.
Comparison of adaptive algorithms for multichannel adaptive equalizers. Application to underwater acoustic communications

Underwater acoustic digital communications are difficult because of the fading multipath nature of the channel. Adaptive equalization is known to highly improve the communication data rate by mitigating intersymbol interference (ISI). Multichannel equalizers are known to further improve the communication by a proper combination of the signals received on a sparse array. The major issue is to select an efficient receiver configuration. There are several parameters that may affect the quality of communication. In this paper, we focus on the main features that influence the performance of adaptive multichannel equalizers, such as the number and positioning of hydrophones, the length of the equalizer, the adaptive algorithm used to update the equalizer's tap gains. The relationship between the multipath structure of the channel and the multichannel receiver's performance is exhibited. Our analysis is performed on real data recorded on two different sea trials.