Miracle-dz/UniFAR-FTUs huggingface dataset:
Improving multiple exclusion homelessness (MEH) services: frontline worker responses to insecure attachment styles

Purpose This study aims to examine the emotional and cognitive responses of frontline homelessness service support staff to the highly insecure attachment styles (AS) exhibited by people experiencing multiple exclusion homelessness (MEH), that is, a combination of homelessness and other forms of deep social exclusion. Design/methodology/approach Focus groups were conducted with frontline staff (N = 19) in four homelessness support services in Scotland. Hypothetical case vignettes depicting four insecure AS (enmeshed, fearful, withdrawn and angry-dismissive) were used to facilitate discussions. Data is analysed thematically. Findings Service users with AS characterised by high anxiety (enmeshed or fearful) often evoked feelings of compassion in staff. Their openness to accepting help led to more effective interactions between staff and service users. However, the high ambivalence and at times overdependence associated with these AS placed staff at risk of study-related stress and exhaustion. Avoidant service users (withdrawn or angry-dismissive) evoked feelings of frustration in staff. Their high need for self-reliance and defensive attitudes were experienced as hostile and dismissing. This often led to job dissatisfaction and acted as a barrier to staff engagement, leaving this group more likely to “fall through the net” of support. Originality/value Existing literature describes challenges that support staff encounter when attempting to engage with people experiencing MEH, but provides little insight into the causes or consequences of “difficult” interactions. This study suggests that an attachment-informed approach to care can promote more constructive engagement between staff and service users in the homelessness sector.
CRISPR/Cas9-mediated TGFβRII disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells in vitro

Background CAR T-cell therapy has been recently unveiled as one of the most promising cancer therapies in hematological malignancies. However, solid tumors mount a profound line of defense to escape immunosurveillance by CAR T-cells. Among them, cytokines with an inhibitory impact on the immune system such as IL-10 and TGFβ are of great importance: TGFβ is a pleiotropic cytokine, which potently suppresses the immune system and is secreted by a couple of TME resident and tumor cells. Methods In this study, we hypothesized that knocking out the TGFβ receptor II gene, could improve CAR T-cell functions in vitro and in vivo. Hereby, we used the CRISPR/Cas9 system, to knockout the TGFβRII gene in T-cells and could monitor the efficient gene knock out by genome analysis techniques. Next, Mesothelin or Claudin 6 specific CAR constructs were overexpressed via IVT-RNA electroporation or retroviral transduction and the poly-functionality of these TGFβRII KO CAR T-cells in terms of proliferation, cytokine secretion and cytotoxicity were assessed and compared with parental CAR T-cells. Results Our experiments demonstrated that TGFβRII KO CAR T-cells fully retained their capabilities in killing tumor antigen positive target cells and more intriguingly, could resist the anti-proliferative effect of exogenous TGFβ in vitro outperforming wild type CAR T-cells. Noteworthy, no antigen or growth factor-independent proliferation of these TGFβRII KO CAR T-cells has been recorded. TGFβRII KO CAR T-cells also resisted the suppressive effect of induced regulatory T-cells in vitro to a larger extent. Repetitive antigen stimulation demonstrated that these TGFβRII KO CAR T-cells will experience less activation induced exhaustion in comparison to the WT counterpart. Conclusion The TGFβRII KO approach may become an indispensable tool in immunotherapy of solid tumors, as it may surmount one of the key negative regulatory signaling pathways in T-cells.
İlk ve Ortaokul Öğretim Programlarında Barış, İnsan Hakları ve Demokrasi Eğitimi

The aim of this study is to determine the learning outcomes of peace, human rights and democracy education in the primary and secondary school curriculum and to evaluate them in accordance with the peace, human rights and democracy education objectives of UNESCO. For that purpose, directed content analysis, one of the qualitative research methods, was used in this research. Research data were obtained from the primary and secondary school curriculum through the document analysis method. Elective courses, compulsory and elective foreign language courses were not included in the study. On the other hand, compulsory courses taught in imam hatip secondary schools were also included in the study. In line with this, the curriculum of 19 courses in total, 4 primary school, 8 secondary school and 7 both primary and secondary school, which were in practice in the spring term of 2019-2020 academic year, was examined through the determinated keywords in accordance with the expert opinions. All the learning outcomes, where the keywords exist, have been listed according to the courses and the class levels. The results of this study indicated that the learning outcomes of peace, human rights and democracy education have existed in the curriculum of the primary and secondary school courses except primary school Mathematics, Physical Sciences, Information Technologies and Software courses; however they don’t present any efficiency as part of the objectives of UNESCO.
How to manage and minimize food waste in the hotel industry: an exploratory research

Purpose The hospitality industry is responsible for significant amounts of waste, more than one-third of which is food waste. Through the comparison between an Italian and a Romanian hotel, this paper aims to provide a better understanding of food waste management trends in the hotel industry as well as to highlight hotel kitchens and hotel food services weaknesses and opportunities to minimize food waste. Design/methodology/approach In-depth interviews, personal communication and observations were conducted to investigate food service planning, food procurement and food waste management, as well as to better comprehend current individuals’ understanding and attitudes, infrastructures, legislative culture and opportunities either from the managerial and the employees’ perspective. Data were analyzed according to a content analysis approach. Findings Three critical hot spots emerged from the analysis: prediction and check of guests’ attendance, communication and transparency with local suppliers and among departments within the unit and purchasing frequency and perishable food provisioning. The accurate forecasting of the number of guests and their nationality is fundamental in avoiding food waste at food service, as well as implementing transparency and communication with local suppliers. Originality/value Although academia and authorities have recognized the crucial importance of food waste management, food waste research in the hotel industry remains under-researched. The present exploratory research contributes to the scarce empirical studies about hotels’ food waste, giving theoretical and managerial recommendations for supporting further studies, highlighting the need for formal deals between hotels and local suppliers (food procurement), as well as the importance of food-networks that holds together companies, retailers and charities (food donation).
Soft skills in developing economies: An African view on the hidden linkage between indigenous knowledge and business perspectives

Although, the soft skills theme has been covered from many angles, there remains a scarcity of research on the linkage between indigenous knowledge and advances of business in developing countries. In addition, there is a gap between the theoretical approaches to the soft skills theme and the practical realities that ask not only which capabilities job seekers need to have but also where to acquire them. While it has been acknowledged that this gap exists, there is a scarcity of research and reports on the topic, and it is often overlooked that, in developing countries, the medium skilled employees and the small scale entrepreneurs are those who need the most support in acquiring knowledge. This fact was highlighted during the COVID pandemic. This paper shows that the provision of soft skills can meet both the requirements and capabilities in developing countries if people are given the chance to learn and master both professional knowledge and soft skills. The authors exhibit a conceptual base and showcase a range of examples, mainly on Africa, where improvement of soft skills has not only helped individuals and businesses but entire sectors of the economy. In the opinion of the authors, a documental presentation with “life stories” often provides more benefit to the readers than an anonymous statistical analysis. Key words: Soft skills, developing countries, entrepreneurship, poverty alleviation, education, employment.
A Feasible Technique in Laparoscopic Excision for Juvenile Cystic Adenomyosis: A Case Report, Literature Review, and Surgical Video

Background: Juvenile cystic adenomyosis (JCA) is a rare uterine lesion. We present the case of a young woman who was diagnosed with JCA and subsequently managed with laparoscopic cyst removal with sharp and blunt dissection. Moreover, we provide a literature review and a surgical video. Case: A 22-year-old nulliparous woman presented with severe dysmenorrhea and was assessed using contrast-enhanced abdominal computed tomography, transvaginal ultrasonography and pelvic magnetic resonance imaging, and diagnosed with a cystic lesion on the left side of the myometrium. She underwent laparoscopic cyst excision and uterine reconstruction. Histology was suggestive of JCA. The dysmenorrhea resolved postoperatively. Conclusion: Surgical resection is the first choice of treatment for cystic adenomyosis, and a laparoscopic approach using scissor forceps is effective.
Assessing the Climate Change Adaptations of Upland Farmers: A Case of La Trinidad, Benguet, Philippines

Adaptation to climate change impacts varies from country to country. It is difficult to capture the concept of adaptations because it includes government policies and the behavior of farmers. Undertaking regional and local assessments of adaptations is still informative because it serves as baseline data for government and other institutions in supporting the needs of the farmers to adapt to the impacts of climate change. Thus, the study aims to look at the institutional supports availed and needed by farmers for climate change adaptation and assess their cost, effectiveness, institutional capacity, and acceptability. Personal interview and Focus Group Discussion complemented by various data gathering techniques was done to provide ample description and understanding of the sources, cost, effectiveness, institutional capacity, and acceptability of the climate change adaptations of farmers in La Trinidad, Benguet. Various institutional supports were given to the farmers but not equally and equitably distributed to the farmers. Almost all of the adaptations were effective, the cost and degree of institutional capacity needed are low but highly acceptable to the farmers.
Impact of COVID-19 on ASEAN5 stock markets

Abstract This article assesses the impact of COVID-19 on ASEAN5 stock markets by applying dynamic panel regression models. Vaccine availability is a crucial factor in this respect. Before the availability of vaccinations, the stringent policy response to COVID-19 impacted stock returns, while, COVID-19 development, and related stringent policies, do not increase volatility. However, with vaccination drives currently in progress, the pandemic’s impact is reducing in severity. Compared to previous financial crises, the current pandemic has a significant, but smaller, impact on ASEAN5 stock markets than the Global Financial Crisis (in terms of both return and volatility) and the taper tantrum (return only), while the impacts of other financial crises were limited. Our empirical results also suggest that local monetary and exchange rate policies could mitigate adverse impacts on regional stock markets.
Massive spider web aggregations in South American grasslands after flooding

1. Major floods of riparian and grassland habitats may lead to a shift in the availability of resources (e.g., food, space) that produces cascading effects on the organisms that rely on it. After flooding occurs, particularly in natural grasslands or agricultural fields, massive aggregative spider webs are occasionally observed. However, given it is an infrequent and unpredictable event, it is seldom reported in detail.
Tourist Environmentally Responsible Behavior and Satisfaction; Study on the World’s Longest Natural Sea Beach, Cox’s Bazar, Bangladesh

This research was aimed at investigating the environmentally responsible behavior of tourists and their satisfaction with a tourist destination. Moreover, this study examined the effects of employee service quality, perceived value, environmental commitment and tourist satisfaction with a destination on loyalty and environmentally responsible behavior. We used data from tourists (n = 640) who had previously visited the world’s longest natural sea beach (Cox’s Bazar, Bangladesh). A partial least square structural equation model (PLS-SEM) method was used in this study to evaluate the proposed model and hypotheses. The results suggest that the perceived value of the destination has a significantly positive impact on both tourist satisfaction and environmental commitment. Similarly, employee service quality significantly impacts perceived value, tourist satisfaction and environmental commitment. Thus, both perceived value and employee service quality also substantially affect the environmentally responsible behavior at the Cox’s Bazar tourist destination. The main contribution of this research involved an investigation of the mediating effects of environmental commitment and tourist satisfaction with a destination on loyalty and environmentally responsible behavior using a single model based on relationship quality theory. Tourist satisfaction was found to completely mediate the relationship between the perceived value of a destination and environmentally responsible behavior, as well as loyalty. In addition, the theoretical and managerial implications for the destination were discussed.
HMM‐TCN‐based health assessment and state prediction for robot mechanical axis

Aiming at the problems of high manual cost, low efficiency, and low precision of the mechanical axis health management in industrial robot applications, this paper proposes a health assessment and state prediction algorithm based on hidden Markov model (HMM) and temporal convolutional networks (TCN). First, the MPdist similarity comparison algorithm is used to construct the mechanical axis health index. Then the hidden Markov model is trained with observable sensor data. After that, the temporal convolution neural network is used to predict state transition time iteratively, and the predicted results are decoded by HMM. The experimental results show that the HMM‐TCN model can accurately assess the health state of the mechanical axis and predict the state transition in real‐time. The prediction accuracy of this method reaches 87.5%, and the error interval locates in [−3,9] time steps. The accuracy, early/late prediction indicators are better than HMM‐RNN, HMM‐LSTM, and HMM‐GRU.
Escaping the Climate Trap: Participation in a Climate-Specific Social Dilemma Simulation Boosts Climate-Protective Motivation and Actions

One way in which educators can help to address increasingly pressing environmental problems, including climate change, is to encourage individuals to change their behavior and to press for structural changes in society. The promotion of climate-protective behavior is challenging because the payoffs for various actions and inactions are structured such that they create social dilemmas. The conflict between short-term personal benefit and long-term collective gain in such dilemmas often leads to self-serving motives that can ultimately be self-defeating. We created a social dilemma simulation specific to climate change, called Climate Trap: Social Dilemma Simulation, to help students observe how they and others respond to these conflicts, and predicted that doing so would lead to climate-protective motivations and behaviors after the simulation. The simulation participants (N = 344) reported greater confidence in their knowledge and understanding of the social dilemma context of climate change, higher environmental concern and more self-determined motivation to act, and they engaged in more climate-protective behaviors compared to the students who did not complete the simulation. Moreover, the simulation participants reported greater pro-environmental engagement on all of the measures after the simulation compared to before they participated in the simulation. The results suggest that a climate-specific social dilemma simulation can create uniquely motivating experiences, and can have utility as a teaching tool, research instrument and intervention.
Light-driven reduction of aromatic olefins in aqueous media catalysed by aminopyridine cobalt complexes

A catalytic system based on earth-abundant elements that efficiently hydrogenates aryl olefins using visible light as the driving-force and H2O as the sole hydrogen atom source is reported. The catalytic system involves a robust and well-defined aminopyridine cobalt complex and a heteroleptic Cu photoredox catalyst. The system shows the reduction of styrene in aqueous media with a remarkable selectivity (>20 000) versus water reduction (WR). Reactivity and mechanistic studies support the formation of a [Co–H] intermediate, which reacts with the olefin via a hydrogen atom transfer (HAT). Synthetically useful deuterium-labelled compounds can be straightforwardly obtained by replacing H2O with D2O. Moreover, the dual photocatalytic system and the photocatalytic conditions can be rationally designed to tune the selectivity for aryl olefin vs. aryl ketone reduction; not only by changing the structural and electronic properties of the cobalt catalysts, but also by modifying the reduction properties of the photoredox catalyst.
Early Carboniferous limestones of southern and central Britain: Characterisation and preliminary assessment of deep geothermal prospectivity

: In Britain, thick limestones of early Carboniferous (Mississippian: 359–323 Ma) age are present in two provinces, respectively south and north of the Wales-Anglo-Brabant landmass. In the southern province, early Carboniferous limestones were deposited upon a southward-deepening shelf, laterally continuous from Ireland to the Rhineland. They now occupy a number of discrete minibasins as a consequence of Variscan orogenic thrusting and significant post-Carboniferous erosion. In the northern province, local tectonic controls led to the development of a mosaic of deepwater basins, ramps and platforms in response to Mississippian extensional stress. The interaction with glacioeustatic sea-level change led to the development of complex carbonate system tracts on these ramps and platforms. Given favourable conditions of palaeokarst development and fracturing, hydraulic transmissivity could be sufficient to allow development as a geothermal resource. Deep geothermal prospectivity is controlled by a hierarchy of factors, operating on scales ranging from provincial (1000–100 km) down to outcrop (1000–100 m), reflecting processes operating on the lithospheric down to sub-basinal scale respectively. On the scale of the individual prospect, these factors include the mode of carbonate deposition, particularly depth of water and angle of depositional slope, which are tectonically controlled; the history of synsedimentary exposure, erosion and karstification, strongly influenced by sea-level change; by the diagenetic history and subsequent basin evolution; by deformation and fracturing during Variscan basin inversion; and by the post-Carboniferous history of subsidence, uplift and karstification. The contrasting impact of these various processes upon hydraulic transmissivity in the two provinces is reviewed, and a preliminary assessment of the geothermal prospectivity of each is presented. The most prospective areas for deep geothermal exploitation are considered to be basins, shelves and platforms lying at depths of 2 to 5 km below sea level. Deepwater basins are considered less prospective because of the lack of thick limestones, except in the hanging wall at fault-bounded margins, where Waulsortian mud-mounds with good residual porosity and fault-zones with polyphase history are likely present. Granite underpinned highs in N England, where Carboniferous limestones are typically at crop, and shallow basins of Carboniferous age lying on the Wales-Anglo-Brabant Massif, are considered less prospective in the deep geothermal context.
‘A vision of paradise lost’: coaching as a grasshopper rather than an ant

ABSTRACT The work of Bernard Suits continues to be discussed in the sports philosophy field, over forty years after the publication of his brilliant book, The Grasshopper: Games, Life, and Utopia. Much of this discussion has looked at how the perfectionist consequences of Suits’ definition of game playing impacts on gamewrighting. However, it is not just the cheat, the trifler, the spoilsport, or even the subperfectionist that the gamewrighter must be concerned with. This paper uses the spirit of the Grasshopper to suggest that what we should also be concerned about in contemporary sport at almost all levels, and what gamewrighting discussions should focus on, is the loss of player autonomy because of the control exerted by coaches, managers and analysts.
Thermotectonic constraints on the geodynamic evolution of the Pindos fold‐and‐thrust‐belt by low‐temperature (U–Th)/He thermochronometry

This study presents new thermochronometric data to constrain the cooling history of the Pindos fold‐and‐thrust‐belt (PFTB) on the NW Peloponnese, and the timing of nappe stacking in the external Hellenides in western Greece. Low‐temperature thermochronology was performed on apatite and zircon minerals extracted from basal exposures of the PFBT in Mt. Erymanthos (NW Peloponnese) using the (U‐Th)/He system. Three bedrock samples collected from a profile across the strike of the PFBT returned thermochronometric ages for the apatite (AHe) between 15 and 9 Ma, while for the zircon (ZHe) the ages are interpreted as unreset (or partially reset). The AHe ages are interpreted as cooling ages related to the Cenozoic geodynamic evolution of the PFTB. Thermal models generated in this research demonstrate two phases of geodynamic evolution of the PFBT during the Cenozoic: an early one associated with the heating of the fold‐and‐thrust belt during 40–20 Ma and a later one associated with fast cooling from 20 Ma onwards. Heating is attributed to the structural thickening of the PFTB while cooling is associated with enhanced uplift and exhumation, which became widespread in Erymanthos by 9 Ma. The initiation of cooling on Mt. Erymanthos echoes the substantial geometric remodelling that underwent the Hellenic arc during the Middle Miocene, associated with slab rollback and arc extension, and is connected to the underplating of the internal segments of the external platform (Gavrovo‐Tripolis unit) by the external metamorphic segments (Mani and Arna units). The current inverse thermal modelling offers the first continuous description of the geodynamic evolution of the most prominent fold‐and‐thrust belt of the Hellenides, from the oceanic stage through basin inversion to uplift and orogen decay.