Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Pain on Breast Cancer Patients' Quality Life: Pain Associated Psychosocial Factors

The onset of cancer disease results in massive lifestyle changes and brings with it overwhelming challenges. Individual psychological features play a crucial role in determining how patients respond and cope with the disease. The main objectives of this research were to study the overall impact of breast cancer [BC] and disease related pain on the patients quality of life [QOL] and to understand the role of selected psychosocial variables [such as anxiety, depression and coping styles] on the perception of pain and QOL. We have studied fifty female BC patients currently undergoing chemotherapy in a tertiary hospital. All our patients were evaluated in a single moment. We have resorted to the use a demographic and clinical questionnaire, the MPQ, the CAD-R, the HADS and the SF-36 questionnaires. We have found that 66% of our patients suffered from pain that could be directly traced to their disease. High intensity of pain was associated to a significant reduction in QOL, expressed both in its physical and mental aspects, and also to higher levels of anxiety and depression. Lower intensity of pain was associated to the use of “Distraction” as a coping strategy. The use of passive coping strategies correlated with a decrease in QO Land with more acute symptoms of anxiety and depression. We conducted two independent regression analyses to determine the relationship between the independent variables [Anxiety and Depression in HADS, PRI and PPI in MPQ, active and passive coping strategies, the condition of having met as t as is or not] and the mental and physical dimensions of QOL and we found that Depression and Anxiety can predict a poor QOL on psychological dimension, whereas for physical dimension, Pain Rating Index and Depression are the variables that best predict low scores in QOL. Conclusions: Pain has a devastating effect on the perception of quality of life as well as on the psychological response irrespective of the stage and severity of the illness.
Valoracin de la Ley 28/2005 de medidas sanitarias frente al tabaquismo

La entrada en vigor en 2006 de la Ley 28/2005 de medidas sanitarias frente al tabaquismo represento un hito en la salud publica moderna en Espana. La ley incluyo tres aspectos regulatorios: elimino la publicidad directa e indirecta y el patrocinio de tabaco, redujo los puntos de venta y prohibio el consumo en lugares de trabajo y espacios publicos cerrados, con algunas excepciones concentradas en establecimientos de restauracion y hosteleria. De manera concomitante con su entrada en vigor se dieron otros cambios con valor preventivo: se elevo la fiscalidad sobre los cigarrillos y se aumentaron los recursos para la prevencion y el tratamiento del tabaquismo, ademas de desarrollarse campanas informativas y un intenso debate social sobre el consumo de tabaco. Evaluar el efecto de la ley de forma aislada es complejo, pero en este trabajo se intenta una aproximacion revisando la informacion disponible, pese a su heterogeneidad. Tras mas de tres anos de su entrada en vigor hay elementos que sugieren un impacto positivo en la prevalencia del tabaquismo en adolescentes, en el consumo general de cigarrillos y en la morbilidad por infarto agudo de miocardio. Las politicas publicas son importantes para la prevencion del tabaquismo y la mejora de la salud de la poblacion, al crear un contexto mucho mas favorable para el abandono del tabaco por los fumadores. Para seguir progresando en la prevencion del tabaquismo habria que eliminar la exencion de las normas sobre consumo en los pequenos locales de restauracion y hosteleria, asi como reforzar la fiscalidad sobre las labores de tabaco para avanzar en la prevencion.
Predictive Modeling of Student Dropout Indicators in Educational Data Mining using Improved Decision Tree

Background/Objectives: Educational Data mining is an emerging interdisciplinary research area that deals with the development of methods to explore data originating in an educational context. The objective of this work is to identify relevant attributes from socio-demographic, academic and institutional data from undergraduate students at the university located in India and develop an improved decision tree algorithm based on ID3 which can able to predict whether the students continue or drop their studies. Methods/Statistical Analysis: The traditional ID3 algorithm is improved by using Renyi entropy, Information gain and Association Function and the model generated by improved decision tree algorithm may be beneficial for university administrators to create guidelines and policies related to raise the enrollment rate in university and to take precautionary and advisory measures and thereby reduce student dropout. It can also used to find the reasons and relevant factors that affect the dropout students. Findings: Experimental results proved that improved decision tree algorithm provides better prediction accuracy in educational data than that of traditional classification algorithms in the literature. Improvements/Applications: Improved decision algorithm was proposed that enhances the ability to form decision trees and thereby to prove that the classification accuracy of improved decision algorithm on educational dataset is greater.
Interactive analysis of geographically distributed population imaging data collections over light-path data networks

The cohort size required in epidemiological imaging genetics studies often mandates the pooling of data from multiple hospitals. Patient data, however, is subject to strict privacy protection regimes, and physical data storage may be legally restricted to a hospital network. To enable biomarker discovery, fast data access and interactive data exploration must be combined with high-performance computing resources, while respecting privacy regulations. We present a system using fast and inherently secure light-paths to access distributed data, thereby obviating the need for a central data repository. A secure private cloud computing framework facilitates interactive, computationally intensive exploration of this geographically distributed, privacy sensitive data. As a proof of concept, MRI brain imaging data hosted at two remote sites were processed in response to a user command at a third site. The system was able to automatically start virtual machines, run a selected processing pipeline and write results to a user accessible database, while keeping data locally stored in the hospitals. Individual tasks took approximately 50% longer compared to a locally hosted blade server but the cloud infrastructure reduced the total elapsed time by a factor of 40 using 70 virtual machines in the cloud. We demonstrated that the combination light-path and private cloud is a viable means of building an analysis infrastructure for secure data analysis. The system requires further work in the areas of error handling, load balancing and secure support of multiple users.
Green Globs: A Microcomputer Application for Graphing of Equations.

, This paper outlines the development of an activity that uses the bomputergs unique capabilities to provide students with a meaningful and highly motivating experience with the graphing of equations. The basic design of the game calls for the computer to display a coordinate grid on which it graphs, any equations that are typed in by the student. Thirteen "Green Globs," each about . 7 units in diameter, are scattered about the grid. The goal of the game is to explode all of the green globs by bitting them with graphs specified by typing in equations, If a shot misses the expected targets, diagnostic feedback is provided to debug the ideas used. The game is scored using an algorithm which encourages cleverly planned shots and provides a wide range of achievable scores. The decision to exclude the,possibility of trigonometry functions in favor of other options is discussed. A _provision of the game allows 'students to view any of en op scoring gates and see what shots and strategies the top players have used. Highlights of classroom use of Green Giobs are provided, including descriptions of techniqaes used by some of the more advanced students. One reference is cited. (CBC)
Porn Star as Brand: Pornification and the Intermedia Career of Rakel Liekki

akel Liekki (“Rachel Flame”) is probably the best-known Finnish female porn performer. Her career has ranged from painting to hardcore videos, Web presence, mobile phone services, newspaper and magazine articles, and television shows. She is a performer, host, producer, and writer who has both appeared in various adult productions and realized her own visions of pornography. As a vocal public discussant on pornography and commercial sex, Liekki has exceptionally flexible media agency. Liekki’s career is representative of the blurred boundaries between pornography and mainstream culture. No longer confined to the realm of shabby sex shops, pornography slides from one representational space to another and shifts increasingly toward mainstream popular culture. Porn’s general visibility has increased in a process termed pornographication (Driver) or, for simpler spelling, pornification: the expansion and success of the porn industry and play with hard-core representations in fashion, advertising, and other fields of popular culture. In what follows we explore pornification as a reorganization of pornography’s cultural position through analysis of Rakel Liekki’s career. With pornification we do not refer to “pornication” or envision a contemporary culture of fornication in the throes of moralistic nostalgia toward some bygone days of chastity. Rather, we aim to figure transformations in the cultural position and status of porn that require a rethinking of its very concept (Nikunen, Paasonen, and Saarenmaa, Pornification). Doing research on contemporary pornography necessitates stepping away from film as the dominant medium and considering the “cross-platform” nature of pornography. Intermediality—“intertextuality transgressing media boundaries” (Lehtonen 71)—and multimodality characterize contemporary media at large, and pornography is Porn Star as Brand:
Creating Video Games in a Middle School Language Arts Classroom: A Narrative Account

This article describes the author’s experience co-facilitating a project for which seventh-grade students designed and created original video games based on Madeleine L’Engle’s A Wrinkle in Time. The author provides an overview of recent literature on video game implementation in the classroom and explains how the project was designed and facilitated, how student engagement changed over time, and how learning outcomes (both expected and unexpected) were assessed. He also reveals how students were encouraged to reflect on the learning process through writing a narrative essay and completing a survey, and concludes with a call for more quantitative research on the topic of using game play for learning purposes.
Assessment of Marketing Faculty Publications at a Major Research University to Satisfy Information Needs

This paper provides an evidence-based assessment of the University of Arkansas Libraries' collections to determine whether they are adequate to support the research and teaching needs of the marketing department. Specifically, it determined where the marketing faculty published, the characteristics of their publications, and the characteristics of their cited references. The study found that the faculty cited more recent literature and a prevalence of journal articles in their cited references. The results also demonstrate the preference of marketing faculty to work in small groups consisting of two to four collaborators.
Paraoxonase1 activity, its Q192R polymorphism and diabetic retinopathy in type 2 diabetes mellitus

Background: The goal of this study was to investigate the role of paraoxonase1 (PON1) status i.e. activity and Q192R polymorphism, in the development of diabetic retinopathy (DR) in patients of type 2 diabetes mellitus. Methods: This cross-sectional study included 55 normotensive type 2 diabetic patients (duration more than 5 years) admitted in the hospital divided into two groups (with and without DR) on the basis of fundus examination by direct ophthalmoscopy. Serum samples of all patients were subjected for PON1 activity with and without salt using paraoxon as substrate and arylesterase activity of PON1 using phenylacetate as substrate. PON1 phenotyping is carried out using ratio of salt stimulated PON1 activity to arylesterase activity. Results: Arylesterase activity of PON1 was found significantly lower in diabetics with DR than diabetic patients without DR (P = 0.01). Multivariate testing also showed its independent protective association in the development of DR (OR 0.958, [95% CI (0.915-1.004)], P value = 0.023). Moreover, DR was associated significantly in diabetic patients with PON1 R allele carriers (71.05%) than diabetic patients with PON1 QQ homozygotes (29.41%). PON1 R carriers had higher Odds ratio (OR) for DR in univariate analysis (OR 5.891, [95% CI (1.676-20.705)], P value = 0.006) and in multivariate analysis (OR 14.12 [95% CI (0.926-215.2)], P = 0.057) after adjustment of conventional risk factors of diabetes. Also diabetics with homozygous PON1 RR were associated significantly with severe forms of DR. Conclusions: Arylesterase activity of PON1 may be more important in the risk of retinopathy in diabetic individual than the paraoxon hydrolytic activity. Moreover PON1 R allele is associated with susceptibility to DR showing a graded risk relationship to the number of R alleles. Thus the determination of PON1 status may be useful in the risk assessment and management of DR. Key
Application of Method of Colour Measurement in Colour Appraisement of Jadeite Jade

The objective colour measurement of jadeite jade is required for colour appraisement of high quality jadeite jade.The characteristics of CIE colorimetric method and colour chart comparison in colour appraisement of jadeite jade are analysed.The differences and relationship between the two methods are also discussed.The research results prove that the application of CIE colorimetric method can exactly represent the physical characteristics and optical perception of colour.The method of colour chart comparison can give consistent estimations for jadeite jade with relative poor transparency.
Effect of individual implicit video-based perceptual training program on high-skilled karatekas’ decision making

Le but de cette etude est de determiner l’efficacite d’un programme d’entrainement perceptif sans feedback en simulation video pour ameliorer les prises de decisions de karatekas de haut niveau. Les participants ont suivi neuf seances d’entrainement individuel perceptif en simulation video au cours desquelles ils devaient mimer le plus rapidement et le plus justement possible, l’action qu’ils auraient fait dans la situation observee. Les resultats revelent une amelioration significative des performances decisionnelles des participants a la suite de la periode d’intervention se traduisant par la diminution de leurs temps de reaction et l’augmentation de la pertinence de leurs decisions. Par ailleurs, il apparait que les bonnes decisions sont plus rapides que les mauvaises decisions. Les resultats sont discutes d’un point de vue scientifique et pratique.
Humanoid Robot Friction Estimation in Multi-Contact Scenarios

This paper proposes a technique for experimentally approximating surface friction coefficients at contacttime in multi-contact applications. Unlike other multi-contact formulations, our approach does not assume a standard friction coefficient, and instead induces slip in a multi-contact oriented humanoid to estimate available friction force. Incrementally increased tangential force, measured with ankle-mounted forcetorque sensors, is used as the basis for slip detection and friction coefficient estimation at the hand. This technique is validated in simulation on a simple three-link model and extended to the humanoid robot platform ESCHER. Approximated friction values are utilized by the robot’s whole body controller to prevent multi-contact end effector slip.
k-anonymous attribute-based access control

Access control in a distributed system can be achieved by requesting digital credentials of the entity wanting to access the system. Credentials contain attributes that attest information concerning a given subject. Because such information can be sensitive, uncontrolled disclosure of such sensitive attributes may result in privacy breaches. Previous research efforts have shown that, even if one discloses only non-sensitive attributes, these attributes can still be linked to specific individuals. In this work, we propose attribute-based authorizations to satisfy the kanonymity property: the set of credentials submitted by a subject during an access control operation should be equal to at least k other such sets received by the counterpart during earlier access controls operations. We thus propose a protocol that ensures k-anonymity for users accessing services in a distributed setting. Our protocol has a number of important features. First, anonymity is user-centric, in that anonymity degree k is defined by the credential submitter itself. A credential submitter before submitting its set of credentials has the assurance that its set will be identical to at least k other sets already stored at the counterpart. This assurance is provided in a privacy-preserving fashion, so that no actual information is leaked about the two negotiating parties data used to build such knowledge. Second, we provide a cryptographic protocol ensuring that the credentials submitted by the submitter during different transactions cannot be linked to each other. Third, we ensure that the critical data exchanged during the protocol are valid.
O7.2Phase 1 first-in-human study of the enhancer of zeste-homolog 2 (EZH2) histone methyl transferase inhibitor E7438

ABSTRACT E7438 (EPZ-6438) is a selective, small molecule inhibitor of EZH2, the catalytic subunit of the polycomb repressive complex 2 that methylates H3K27. Hypertrimethylation of H3K27 (H3K27Me3) appears tumorigenic in various malignancies, including subsets of Non-Hodgkin Lymphoma (NHL) with mutant EZH2. Inhibition of H3K27Me3 with E7438 leads to killing of EZH2 mutant lymphoma cells. Tumors with loss of INI1, a subunit of the SWI-SNF chromatin remodelling complex, also appear dependent on EZH2. E7438 induces apoptosis and differentiation of INI1-deleted malignant rhabdoid tumor (MRT) models in vitro and in vivo. E7438 was administered PO BID to cohorts of 3 to 6 pts up to a maximum feasible dose of 1600 mg BID. Blood samples for PK and skin biopsies for PD analysis were collected. PD samples were stained with H3K27me3 specific antibody and change from baseline was determined. PK/PD relationship was analysed. Tumour assessments were performed every 8 weeks. As of 14 August 2014, 21 patients (pts) have been enrolled and treated at 5 dose levels of 100, 200, 400, 800, and 1600 mg BID. B cell NHL patients included follicular lymphoma (FL, n = 4), DLBCL (n = 4, including 1 pt with primary mediastinal lymphoma [PMBL] and marginal zone lymphoma (n = 1)). Solid tumour (ST) pts included 1 pt with MRT. 11 pts (7 ST, 4 B-cell NHL) had at post-treatment tumour assessment. Median age was 59 yrs (range 23-83). 1 DLT of thrombocytopenia was reported at 1600mg BID. Frequently occurring AEs independent of causality were asthenia (8 pts), anaemia (4 pts), decreased appetite and diarrhoea (3 pts each), pulmonary embolism, insomnia, muscle spasms, thrombocytopenia, nausea, and vomiting (2 pts each). 5/21 pts experienced Grade 3/4 AE. E7438 PK exhibit rapid absorption, dose related increase in exposure and rapid elimination (half-life ∼ 4hr). There was an exposure-related decrease in H3K27Me3 positive cells in skin. Partial responses were demonstrated in 2 of 4 evaluable NHL pts and in 1 pt with MRT with INI1 deficiency. Cohort expansion is ongoing. Updated data will be presented. E7438 is well tolerated up to 1600 mg BID with preliminary evidence of activity in NHL and MRT and exposure related inhibition of H3K27Me3. MTD has not been reached.
On the Limits of Molecular Communication with Coexisting Biological Systems Towards the Internet of Bio-Nano Things

Interference is a key challenge for communication systems, whether wireless for the Internet of Things or emerging approaches for the Internet of Bio-Nano Things. In the case of molecular communication between biochemical systems, interference can impact not only other communication systems, but also any nearby biological system. This leads to a different coexistence problem, where communication is constrained such that the function of the biological system is preserved. In this paper, we develop a new model for the interactions between the communication and biological systems, incorporating memory in the channel between the communication and biological systems. We then obtain an impossibility result limiting the amount of information that can be transmitted. In particular, the number of messages scales as √ n with the blocklength n.
Обеспеченность витамином D детей разных возрастных групп в зимний период

The paper gives an update on the biological role of vitamin D in the human body, its metabolic pathways, and potential abnormalities resulting in reduced provision. Objective: to determine vitamin D provision in the children of Kazan during the winter season. Examinations were made in 309 children, including 171 infants aged 1 month to 3 years and 138 children 6 to 18 years of age. Serum 25(OH)D levels were determined by chemiluminescence immunoassay at the EFiS Research Center (Moscow). In infants under 3 years of age, the mean 25(OH)D values were 18,2±1,0 ng/ml, while only 14,8% of the patients were found to have normal 25(OH) D values of (more than 30 ng/ml) and the rest had vitamin D metabolite insufficiency or deficiency. The winter vitamin D level was consistent with the normal ones in 11,2% of the schoolers, lower in 122 (88,8%) children; the provision of vitamin D was at its deficiency level (less than 10 ng/ml) in 33 (24%) children. The findings suggest that it is necessary to prescribe vitamin D for all children under the age of 18 during winter and autumn. It is best to determine the initial level of the metabolite and to use its dose corresponding to that of vitamin D.
Vehicular Ad Hoc Networks: Growth and Survey for Three Layers

A vehicular ad hoc network (VANET) is a mobile ad hoc network that allows wireless communication between vehicles, as well as between vehicles and roadside equipment. Communication between vehicles promotes safety and reliability, and can be a source of entertainment. We investigated the historical development, characteristics, and application fields of VANET and briefly introduced them in this study. Advantages and disadvantages were discussed based on our analysis and comparison of various classes of MAC and routing protocols applied to VANET. Ideas and breakthrough directions for inter-vehicle communication designs were proposed based on the characteristics of VANET. This article also illustrates physical, MAC, and network layer in details which represent the three layers of VANET. The main works of the active research institute on VANET were introduced to help researchers track related advanced research achievements on the subject.