Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effects of Anxiety Levels on Burnout Syndrome in Nurses

GİRİŞ ve AMAÇ: Fiziksel ve ruhsal nedenler yaşanan, çalışma ortamları olumsuz etkileyen anksiyete ve tükenmişlik sendromu hem bireyi hem de örgütü olumsuz etkileyen kavramlardır. Son zamanlarda yoğun olarak yaşanan bu kavramlar “başaramama, yıpranma, çalışma istek ve arzusunun azalması veya tatmin edilemeyen istekler sonucunda bireyin iç dünyasında meydana gelen tükenme ile bireyin hayatında gerçekleşen değişimleri ifade etmektedir. Bu araştırma ile yoğun çalışma ortamında bulunan hemşirelerin anksiye düzeyleri ve bu düzeylerin tükenmişlik sendromu ile ilişkisinin varlığını ortaya çıkarmak amaçlandı
Evaluation of protective effects of GnRH agonist or antagonist on ovarian reserve with anti-Müllerian hormone and histological analysis in a rat model using cisplatin

Introduction The aim of this prospective trial was to evaluate the ovarian reserve with anti-Müllerian hormone (AMH), which is the best predictor of ovarian reserve, and perform histological analysis after exposure to cisplatin with a GnRH agonist or antagonist. Material and methods Twenty-four Wistar albino rats were randomly divided into three groups, each consisting of eight rats. In the GnRH agonist group (group 1), rats received a single dose of 50 mg/m2 cisplatin with 1 mg/kg triptorelin. In the GnRH antagonist group (group 2), rats received a single dose of 50 mg/m2 cisplatin with 1 mg/kg cetrorelix. In the control group (group 3), rats received 50 mg/m2 cisplatin. Ovarian reserve was assessed by AMH and histology. Results Primary follicle counts were higher in group 2 (4.50 ±1.47 vs. 3.50 ±1.70 vs. 3.00 ±3.54) and secondary follicle counts were higher in group 1 (2.96 ±1.11 vs. 1.74 ±1.03 vs. 1.37 ±3.11). Numbers of tertiary follicles were higher both in groups 1 and 2 than the control group (1.36 ±0.83 vs. 0.84 ±0.99 vs. 0.50 ±0.75). The total follicle count of the study groups were significantly higher compared with the control group (14.32 ±5.96 vs. 12.48 ±4.12 vs. 10.63 ±6.80). AMH was significantly higher in groups 1 and 2 compared with the control group (18.56 ±25.33 vs. 16.48 ±24.66 vs. 9.37 ±26.54). Conclusions This is the first prospective randomized controlled study showing the protective effects of GnRH agonist and antagonist on ovarian reserve after cisplatin exposure in an animal model.
Combined Detection of Serum MiR-221-3p and MiR-122-5p Expression in Diagnosis and Prognosis of Gastric Cancer

Purpose To investigate the clinical value of serum miR-221-3p and miR-122-5p expression levels in the diagnosis and prognosis of gastric cancer. Materials and Methods Serum samples from 141 gastric cancer cases (gastric cancer group), 110 gastric polyps (gastric polyp group), and 75 healthy people (healthy control) were used to detect miR-221-3p and miR-122-5p expression using real-time reverse transcription polymerase chain reaction. Results Serum miR-221-3p expression was significantly higher in the gastric cancer group than in the gastric polyp group, and it was significantly lower than that before operation. The miR-221-3p expression was significantly higher in the death group than in the survival group. The proliferation and migration ability significantly increased and the apoptosis rate significantly decreased by miR-221-3p transfection in gastric cancer cells. In contrast, the function of miR-122-5p in gastric cancer cells was opposite of miR-221-3p. Serum miR-221-3p expression was negatively correlated with that of miR-122-5p in gastric cancer. Serum miR-221-3p and miR-122-5p expressions were significantly correlated with the degree of differentiation, tumor, node, metastasis stage, lymph node metastasis, and invasion depth. miR-221-3p and miR-122-5p expression levels were independent prognostic factors for postoperative gastric cancer. In the diagnosis and predicting prognosis of gastric cancer, receiver operating characteristic analysis revealed that the area under curve of combined detection of serum miR-221-3p and miR-122-5p expression had a greater diagnostic effect than either single maker. Conclusions The miR-221-3p and miR-122-5p are involved in the development of gastric cancer, and they have important clinical values in gastric cancer diagnosis and prognosis.
Healthcare Practices Related to Neonatal Abstinence Syndrome

The incidence of Neonatal Abstinence Syndrome (NAS) is abounding in hospitals across the nation due to the recent surge in opioid abuse. This thesis explores the variation in protocols and guidelines used by healthcare practitioners concerning NAS. This study consisted of a literature review as well as observations and interviews with healthcare practitioners in Neonatal Intensive Care Units (NICUs). The literature review revealed there has been a greater increase in NAS among rural areas, and there is currently no national standardized protocol for the treatment of NAS. Field notes taken during the interviews and observations confirmed the literature in that each NICU’s protocol varied, although they were similar in many aspects. Five main themes were identified from the field notes, as well. In conclusion, it may prove beneficial to look into the development process of similar disease protocols such as Fetal Alcohol Syndrome (FAS) to gain insight to aid in the creation of a standardized protocol for NAS.
A Study on Stroke Patients' ADL, Depression, Self-Efficacy and Quality of Life

This study was a descriptive research in search of a nursing intervention scheme to improve stroke patients' quality of life by understanding the relationship of stroke patients' ADL, depression, self-efficacy and quality of life with various variables and identifying factors that affect their quality of life. Each subject was interviewed one to one based on a structured questionnaire. With regard to research tools, Modified Barthel Index (MBI: Fortinsky et al., 1981), which was translated by Choi, Hye-sook (1996), was used in measuring ADL, Randloff's (1977) tool, which was translated by Choi, Soon-hee, was used in measuring depression, and the tool developed by Sherer et al. (1982), which is to measures self-efficacy under general conditions not limited to specific conditions, and modified by O, Bok-ja (1994) was used in measuring self-efficacy. The quality of life was measured using the scale of satisfaction of life developed by Diener et al. (1985). The results of this study were as follows: 1. The means of ADL of the subjects was , depression , self-efficacy , and the quality of life . 2. The subjects' quality of life showed a statistically significant difference according to gender (t=7.9, p= .006), satisfaction with income (F=5.8, p= .004), the burden of medical fee (F=3.7, p= .028) and the period of disease (F=2.8, p= .042). 3. With regard to relationship among ADL, depression, self-efficacy and the quality of life, ADL was in a relatively low positive correlation (r= .293, p= .003) with and the quality of life, depression in a high negative correlation (r=- .634, p= .000) with the quality of life, and self-efficacy in a positive correlation with the quality of life (r= .388, p= .000). 4. Factors that made a significant influence on the quality of life were depression (B=- .309, p= .001) and satisfaction with income (B=-2.611, p= .001). Based on these results, this study made following suggestions: 1. It is necessary to run rehabilitation programs to improve stroke patients' ADL, depression and self-efficacy. 2. It is necessary to perform research of monitoring stroke patients' quality of life in various areas using measuring tools.
Microbiological Profile of Ocular Infections: In Reference to their Resistance and Biofilm Formation

The eye and its associated structures are distinctive predisposed to infection by the various microorganisms. External & internal infections can lead to visual impairments, which is a major public health problem. Bacteria are the most frequent pathogens affecting ocular Structures; the increasing rate of antimicrobial drug resistance is a worldwide concern. The prevalence and severity of infection depends on the site of infection and type of infectious agents. The present study was aimed to determine the incidences of bacterial and fungal ocular infections and to assess the antibiotic susceptibility pattern of these etiological agents. Clinical samples were collected from various hospitals/clinics of Surat since December 2018. From total collected clinical samples 87% of samples produced positivity. Many of them were polymicrobial. From positive cases, associated pathogens were isolated and identified based on standard microbiology procedures and predominance of Gram Positive Cocci 38 (51.35%) were observed, followed gram negative short rods 26 (35.13%) and 10 (13.51%) cases of fungal infections. Isolates were further tested for their antibiotic susceptibility patterns against commonly used antimicrobials. Association between type of infections and etiological agents was also studied. Bacterial & Fungal isolates were predominantly isolated from all the Ocular cases includes Conjunctivitis, Corneal Ulcer, Keratitis, Blepharitis, Dacryocystitis, Scleritis and Endophthalmitis but higher cases of fungal infections were observed in corneal ulcer. Conjunctivitis was the dominant ophthalmic disease followed by corneal ulcer. Early access to clinical and microbiological diagnosis with appropriate treatment can prevent the ocular morbidity and mortality.
"Using Twitter to Identify Patient Education Topics for Using Medical Marijuana for Cancer Pain Management"

According to the National Institute on Drug Abuse, “the term medical marijuana (MMJ) refers to using the whole, unprocessed marijuana (or cannabis) plant or its basic extracts to treat symptoms of illness and other conditions [1]. ” Cannabinoids are the active constituents found within the marijuana plant; cannabidiol (CBD), one of many cannabinoid compounds found in cannabis, has been proposed as an alternative approach to managing chronic pain [2].
OTT_A_210567 6947..6959

Dan Jiao Yingying Liu Zhen Tian 1Department of Ultrasound, China-Japan Union Hospital, Jilin University, Changchun 130033, People’s Republic of China; 2Department of Nephrology, China-Japan Union Hospital, Jilin University, Changchun 130033, People’s Republic of China; 3Department of Cardiology, China-Japan Union Hospital, Jilin University, Changchun 130033, People’s Republic of China Backgrounds: microRNA-493-3p (miR-493) has been reported to be critically downregulated in multiple types of human cancer. However, the expression level, biological roles and underlying mechanism of miR-493 in tongue squamous cell carcinoma (TSCC) remain to be elucidated. Methods: RT-qPCR was utilized for the determination of miR-493 expression in TSCC tissues and cell lines. The influence of miR-493 overexpression on TSCC cell proliferation, apoptosis, migration, invasion in vitro and tumor growth in vivowere explored viaMTTassay, flow cytometry analysis, cell migration and invasion assays, and xenograft tumors in nude mice, respectively. Bioinformatics analysis, luciferase reporter assays, RT-qPCR andWestern blotting were performed to clarify the potential mechanisms involved in the action of miR-493 in TSCC cells. Results: miR-493 was significantly downregulated in TSCC tissues and cell lines. Decreased miR-493 expression was notably correlated with tumor differentiation, depth of invasion and TNM stage. Additionally, patients with TSCC having low miR-493 expression showed lower overall survival rate. Functionally, miR-493 upregulation inhibited TSCC cell proliferation, migration, invasion in vitro; induced cell apoptosis; and decreased the tumor growth in vivo. Bioinformatics analysis followed by luciferase reporter assays also demonstrated that miR-493 directly bound to the 3ʹ-untranslated region of high-mobility group AT-hook 2 (HMGA2) in TSCC cells, and therefore reduced HMGA2 expression at the mRNA and protein level. Furthermore, HMGA2 was overexpressed in TSCC tissues and inversely correlated with miR-493. Moreover, silenced HMGA2 expression simulated the tumor-suppressing roles of miR-493 overexpression on TSCC cells. HMGA2 overexpression eliminated the inhibitory roles of miR-493 overexpression on TSCC cells. Conclusion: These observations demonstrated that miR-493 is a tumor suppressor inhibited the oncogenicity of TSCC cells by directly targeting HMGA2. These results provide sufficient evidence for the miR-493/HMGA2 axis as a novel therapeutic target for the treatment of patients with TSCC in the future.
Diagnostic Accuracy and Predictive Value of Latex Agglutination Test, Rapid Cassette Test Compared to ELISA in Diagnosis of Toxoplasma gondii in Pregnant Sudanese Women

Background: There are different procedures for the diagnosis of the pregnant female suspected with toxoplasmosis, however time, cost, and accuracy of the test should meat patients need. Material and Method: Three hundered pregnant female collected from Saad Abualila hospital antenatal care unit, were undergo three different procedures for the diagnosis of Toxoplasma gondii infection. Toxolatex. Toxo IgG-IgM rapid test and ELISA were done for all pregnant female. The result described as frequency and percentage of positivity, also specificity and sensitivity of Toxolatex. Toxo IgG-IgM rapid test were assessed according to ELISA results. Results: The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy for Latex agglutination test to detect T. gondii antibodies were: 44.6%, 71.9%, 30.5%, 82.4% and 66. %, while the specificity, sensitivity, PPV, NPV and diagnostic accuracy for rapid cassette test to detect T. gondii antibodies were: 29.2%, 88.5%, 41.3%, 81.8% and 75.67%, respectively. Conclusion: Toxo IgG-IgM rapid test(casset) considered as good test for diagnosis of toxoplasmosis and mor specific than Toxolatex with also high diagnostic accuracy.
OX40 (CD134) and OX40 ligand, important immune checkpoints in cancer

Abstract Immunotherapy has shown promising results in cancer treatment. Research shows that most patients might be resistant to these therapies. So, new immune therapies are needed. OX40 (CD134) and OX40 ligand (OX40L), costimulatory molecules, express on different types of immune cells. The interaction between OX40 and OX40L (OX40/OX40L) induces the expansion and proliferation of T cells and decreases the immunosuppression of regulatory T (Treg) cells to enhance the immune response to the specific antigen. For the important role OX40 takes in the process of immunity, many clinical trials are focusing on OX40 to find out whether it may have active effects in clinical cancer treatment. The results of clinical trials are still not enough. So, we reviewed the OX40 and its ligand (OX40L) function in cancer, clinical trials with OX40/OX40L and the correlation between OX40/OX40L and other immune checkpoints to add more ideas to tumor feasible treatment.
Clinical Case: Place of Cardiac Stimulation in Asymptomatic Significant Chronic Aortic Insufficiency Associated with Sinus Dysfunction

The association between aortic insufficiency and sinus dysfunction is rare. We reported a case of significant chronic degenerative aortic insufficiency associated with sinus dysfunction. This was a 66-year-old patient on follow-up for asymptomatic chronic aortic insufficiency who was referred to us for a preoperative invasive hemodynamic assessment. The indication for surgery was based on the left ventricular dilation criteria. The echocardiography and cardiac catheterization showed a disappearance between the aortic insufficiency and the left ventricular repercussion. Upon discovery of the sinus bradycardia, the patient received a single chamber pacemaker set at a base rate of 70 seconds in AAIR at first and then the patient was measured remotely. At five months, cardiac pacing resulted in a significant reduction in the left ventricular diameter and volume on the echocardiography and magnetic resonance imaging; therefore surgery was postponed.
Development of prediction model for identifying heart failure patients with high risk of developing hyponatremia

Background: Despite its significant contribution to morbidity and mortality, studies reported that hyponatremia is still inadequately recognised and treated. Objective: To obtain a prediction model for predicting the risk of hyponatremia in patients hospitalized from heart failure. Methods: Patients included in this research were patients hospitalized from heart failure at Fatmawati Hospital in Jakarta, Indonesia during the 2011 – 2014 period. Logistic regression analysis was performed for the derivation of prediction model by including variables obtained during admission as the predictors. Brier-score and Nagelkerke R2 (NR2) were measured to assess overall predictive ability and area under the curve (AUC) of the Receiver Operating Characteristics (ROC) and calibration plot along with Hosmer-Lemeshow test were measured to assess discrimination and calibration ability, respectively. Internal validation was performed using a bootstrapping approach. Results: Out of 464 patients included in the research 102 (22%) were hyponatremic during hospitalization. Accordingly, 306 non-hyponatremic patients were selected as controls matched by age and gender. Variables significantly associated with hyponatremia were serum sodium level, fatigue, ascites, positive inotropes, heparin and antibiotics. Prediction model containing those six variables exhibits good predictive ability both overall (brier-score=0.107, NR2=0.531) and specifically of discrimination (AUC of ROC curve=0.90) and calibration ability (p-value of HL test=0.899). Optimism observed from internal validation did not reduce its predictive performance. Conclusion: Risk prediction for predicting the risk of hyponatremia in patients hospitalized from heart failure can be derived by including predictors taken from information obtained during admission.
Outpatient healthcare access and utilization for neonatal abstinence syndrome children: A systematic review

Abstract Objective: The objective of this study was to systematically assess the literature regarding postnatal healthcare utilization and barriers/facilitators of healthcare in neonatal abstinence syndrome (NAS) children. Methods: A systematic search was performed in PubMed, Cochrane Database of Systematic Reviews, PsychINFO, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science to identify peer-reviewed research. Eligible studies were peer-reviewed articles reporting on broad aspects of primary and specialty healthcare utilization and access in NAS children. Three investigators independently reviewed all articles and extracted data. Study bias was assessed using the Newcastle–Ottawa Assessment Scale and the National Institute of Health Study Quality Assessment Tool. Results: This review identified 14 articles that met criteria. NAS children have poorer outpatient appointment adherence and have a higher rate of being lost to follow-up. These children have overall poorer health indicated by a significantly higher risk of ER visits, hospital readmission, and early childhood mortality compared with non-NAS infants. Intensive multidisciplinary support provided through outpatient weaning programs facilitates healthcare utilization and could serve as a model that could be applied to other healthcare fields to improve the health among this population. Conclusions: This review investigated the difficulties in accessing outpatient care as well as the utilization of such care for NAS infants. NAS infants tend to have decreased access to and utilization of outpatient healthcare following hospital birth discharge. Outpatient weaning programs have proven to be effective; however, these programs require intensive resources and care coordination that has yet to be implemented into other healthcare areas for NAS children.
Estrategias de afrontamiento y crecimiento postraumático en mujeres con y sin cáncer de mama

Entendemos por Crecimiento Postraumático (CPT en adelante) el cambio positivo que un individuo puede llegar a experimentar tras un suceso traumático. Padecer cáncer de mama constituye una experiencia traumática, tanto por el impacto del diagnóstico, como por los tratamientos administrados. No obstante, toda persona vivencia momentos traumáticos a lo largo de sus vidas, pudiendo obtener a partir de ellos ciertos beneficios y/o CPT, o no. Consideramos que el desarrollo de CPT a partir de experiencias traumáticas puede verse promovido, o dificultado, por el uso de diferentes estrategias de afrontamiento (EA en adelante). Es por ello que en el presente estudio nos planteamos como objetivos: 1) comprobar si existen diferencias estadísticamente significativas en los niveles de CPT y las EA empleadas entre mujeres con cáncer de mama y sanas, 2) explorar la existencia de correlaciones estadísticamente significativas entre las EA empleadas y el nivel de CPT;y 3) analizar la posible capacidad explicativa y predictiva del uso de diversas EA y el desarrollo de CPT, controlando el posible efecto de la edad y la enfermedad. Participaron un total de 110 mujeres, 45 con cáncer de mama (40.9%) y 55 sin cáncer (59.1%). Se administraron el Inventario de Crecimiento Postraumático (PTGI) de Tedeschi y Calhoum (1996) y la versión española del Coping Strategies Inventory (Cano y cols, 2007). Los resultados informan que ambos grupos de mujeres se diferenciaron en el uso de la EA expresión de emociones; que el CPT correlaciona con distintas EA, siendo las EA apoyo social y la resolución de problemas las que explican y predicen el CPT, con independencia de la edad y la enfermedad. Concluimos en la necesidad de que ambas EA deberían ser incorporadas en intervenciones dirigidas a la promoción del CPT en mujeres que han padecido una experiencia traumática, sea esta clínica o no.
Noninvasive Ventilation Use in Critically Ill Patients with Acute Asthma Exacerbations.

RATIONALE Non-invasive ventilation decreases the need for invasive mechanical ventilation and mortality among patients with chronic obstructive pulmonary disease but has not been well studied in asthma. OBJECTIVE To assess the association between non-invasive ventilation and subsequent need for invasive mechanical ventilation and in-hospital mortality among patients admitted with asthma exacerbation to the intensive care unit. METHODS We performed a retrospective cohort study using administrative data collected during 2010-2017 from 682 hospitals in the United States. Outcomes included receipt of invasive mechanical ventilation and in-hospital mortality. Generalized estimating equations, propensity-matched models, and marginal structural models were used to assess the association between non-invasive ventilation and outcomes. MEASUREMENTS AND MAIN RESULTS The study population included 53,654 participants with asthma exacerbation. During the study period 13,540 patients received non-invasive ventilation (25.2%; 95% CI 24.9%, 25.6%), 14,498 underwent invasive mechanical ventilation (27.0%; 95% CI 26.7%, 27.4%), and 1,291 died (2.4%; 95% CI 2.3%, 2.5%). Among those receiving non-invasive ventilation, 3,013 patients (22.3%; 95% CI 21.6%, 23.0%) required invasive mechanical ventilation after first receiving non-invasive ventilation, 136 of whom died (4.5%; 95% CI 3.8%, 5.3%). Across all models, the use of non-invasive ventilation was associated with a lower odds of receiving invasive mechanical ventilation (adjusted generalized estimating equation OR 0.36; 95% CI 0.32, 0.40) and in-hospital mortality (OR 0.48; 95% CI 0.40, 0.58). Those who received non-invasive ventilation prior to invasive mechanical ventilation were more likely to have comorbid pneumonia and severe sepsis. CONCLUSIONS Non-invasive ventilation use during asthma exacerbation was associated with improved outcomes but should be used cautiously with acute comorbid conditions.