Miracle-dz/UniFAR-FTUs huggingface dataset:
Sox 9-induced chondrogenesis in mesenchymal stem cells was mediated by ERK 5 signal pathway

Sox9 is a member of the high-mobility-group (HMG) box protein superfamily, which is expressed predominantly among cells in mesenchymal condensations during the early development of embryonic skeletons. The extracellular-signal-regulated kinase 5 (ERK5) is one of the mitogen-activated protein kinase (MAPK) family members of protein kinases. Roles for ERK5 signaling in the regulation of chondrogenesis and adult chondrocyte homeostasis have yet to be demonstrated. In this study, we found that ERK5 could down-regulate Col2al and Sox9 expression, and this down-regulation was inhibited by MEK5β, one of ERK5 inhibitor. Furthermore, we characterized the ERK5 response with the chromatin binding profile of Sox9 in MSCs in a genome-wide manner through an analysis of ChIP-seq data. This study will help to understand the interaction between the ERK5 and Sox9, and facilitate to decipher the mechanism of chondrogenesis in mesenchymal stem cells.
Interactive comment on “ Revising the stochastic iterative ensemble smoother

This manuscript reformulates the algorithm of the original ensemble randomized maximum likelihood (EnRML), a stochastic EnKS, and compares its performance with other iterative schemes using the Lorenz-96 model. The manuscript is well written. I basically have no critical comment on the proposed method. However, I would like to recommend the authors performing some additional Lorenz-96 experiments to discuss differences between EnRML and iterative EnKS. For example, the following experiments would be interesting: (1) experiments with imperfect observation error variance (2) experiments with higher nonlinearily (e.g., larger obs error or infrequent assimilation)
TRƯỜNG ĐẠI HỌC SƯ PHẠM TP HỒ CHÍ MINH

In this paper, we present our search for debris disks in a sample of nearby late-M dwarfs based on infrared data of the Wide Infrared Survey Explorer. Using archival data, we constructed spectral energy distributions of these targets to detect their infrared excess. We detected infrared excess only in one target. This late-M dwarf is an excellent benchmark for further study of disks around very low-mass objects.
Efficient Computation of SAR and Temperature Rise Distributions in a Human Head at Wide Range of Frequencies Due to 5 G RF Field Exposure

─ In this paper, the effects of radio frequency electromagnetic fields produced by base stations on a human head are investigated with the aid of a multiphysics model at multiple frequencies using a single simulation. This multiphysics model is based on integrating the Debye model of human head dispersive tissues parameters into the finite-difference time-domain method by using the auxiliary differential equation approach and then calculating the specific absorption rate and temperature rise distributions in the head with the use of bioheat equation. The effects of frequency and incident angle of radio frequency electromagnetic fields on the specific absorption rate and temperature rise distributions in the head are analyzed. Index Terms ─ Biologic effects of electromagnetic radiation, dispersive head, FDTD method, multiphysics model, specific absorption rate, temperature rise.
Interculturally Differentiated Instruction : Reflections from Cyprus Classrooms

Nowadays, teachers are called to address the needs of all students in their culturally-diverse and mixedability classrooms. Despite the widespread concern about the underachievement and marginalisation of students with disabilities and students from diverse cultural backgrounds; the reasons for this have, for too long, been attributed to the students and their families, rather than to the curricular, pedagogical, and organisational structures of schools and the inequitable framework of our society. Within this context, two pedagogical approaches appeared in the research and literature: intercultural education and differentiated instruction that only recently have been combined to form interculturally differentiated teaching. In this paper, we examine the implementation of interculturally differentiated instruction by Cypriot teachers in real, mixed ability, and culturally diverse classroom settings. Our analysis indicates that teachers are unable to connect intercultural competence with educational effectiveness, consequently failing to create inclusive instructional practises that could maximise learning potential along with intercultural competence for all children. Based on these findings, we question the effectiveness of teacher professional development on interculturally differentiated teaching.
A MODIFIED MASS LUMPING PROCEDURE FOR THE MIXED HYBRID FINITE ELEMENT METHOD APPLIED TO UNSATURATED WATER FLOW MODELLING

This article deals with variably saturated flow modeling. Mixed Hybrid Finite Element (MHFE) methods have become popular in recent years for modeling groundwater flow. A new procedure of mass lumping, suitable for various shapes of 2D elements, is developed to avoid unphysical oscillations obtained with the standard MHFE scheme. Efficiency of this formulation is demonstrated for the simulation of sharp infiltration fronts in the vadose zone.
List 9-17-2018 Application of Novel and Existing Methods to Identify Genes with Evidence of Epigenetic Association : Results from GAW 20

Background: The rise in popularity and accessibility of DNA methylation data to evaluate epigenetic associations with disease has led to numerous methodological questions. As part of GAW20, our working group of 8 research groups focused on gene searching methods. Results: Although the methods were varied, we identified 3 main themes within our group. First, many groups tackled the question of how best to use pedigree information in downstream analyses, finding that (a) the use of kinship matrices is common practice, (b) ascertainment corrections may be necessary, and (c) pedigree information may be useful for identifying parent-of-origin effects. Second, many groups also considered multimarker versus single-marker tests. Multimarker tests had modestly improved power versus single-marker methods on simulated data, and on real data identified additional associations that were not identified with single-marker methods, including identification of a gene with a strong biological interpretation. Finally, some of the groups explored methods to combine singlenucleotide polymorphism (SNP) and DNA methylation into a single association analysis. Conclusions: A causal inference method showed promise at discovering new mechanisms of SNP activity; gene-based methods of summarizing SNP and DNA methylation data also showed promise. Even though numerous questions still remain in the analysis of DNA methylation data, our discussions at GAW20 suggest some emerging best practices.
The Effect of Filial Therapy on Somatized Symptoms , Parent-child Interaction and Parents ’ Empathy with Child Survivors of the 2015 Nepal Earthquake *

This study found that child survivors of the 2015 Nepal earthquake have suffered psychological trauma and unstable living conditions in the aftermath. Furthermore, if the children’s trauma is neglected, it is likely to be aggravated and become chronic until adulthood. Parent-child relationships are the first relationship that a child has, and parents and children tend to have a close relationship with each other. Through this relationship, the child grows and develops. Filial play therapy has proven to be effective as a psychological intervention program for children in parent-child relationships. This study examined the effects of filial play therapy on the somatization symptoms, parent-child interaction, and empathy ability of child survivors of the Nepal earthquake. As a result, the children’s symptoms of somatization were found to have significantly decreased, and it was effective in enhancing parent-child interaction and parental empathy. We also analyzed the process of change through filial play therapy with the parents. As a result, we were able to see the process of change and understand the anxious minds of those parents tried to read their children’s minds.
Expression , Purification and Characterization of meta-cleavage Enzyme CarBaBb from Novosphiongobium sp . KA 1

Carbazole is a compound produced from impurities of fossil fuel which share the similar plane structure of the dioxin family and is also characterized to be a recalcitrant chemical and was reported to have carcinogen properties [1]. Isolation of bacteria capable of degrading carbazole as sole carbon and nitrogen source have been reported and genes responsible for degradation of aromatic compounds have been discovered and characterized extensively [2, 3, 4, 5].
IL-7 d 5 protein is expressed in human tissues and induces expression of the oxidized low density lipoprotein receptor 1 ( OLR 1 ) in CD 14 + monocytes

Objectives: The 6-exon-spanning ‘canonical’ Interleukin-7 (IL-7c) is a non-redundant cytokine in human T-cell homeostasis that undergoes extensive alternative pre-mRNA splicing. The IL-7 gene variant lacking, exon 5 (IL-7d5), exhibits agonistic effects as compared to IL-7c. We studied in this report for the first time the protein expression of IL-7d5 variant in tissues and its role in monocyte activation. Methods: We visualized the expression of IL-7d5 protein by immunohistochemistry in both healthy and malignant (human) tissues and investigated the impact of IL-7d5 stimulation on CD14+ monocytes using gene expression analysis and flow cytometry. Results: IL-7d5 is largely expressed by human epithelial cells, yet also by stromal cells in malignant lesions. Gene expression analysis in CD14+ monocytes, induced by the 6-exon spanning IL-7 or IL7d5 showed similar changes resulting in a pro-inflammatory phenotype and increased expression of genes involved in lipid metabolism. IL7d5 was superior in inducing upregulation of the oxidised low density lipoprotein receptor (OLR), measured by flow cytometry, in CD14+ cells. Conclusion: IL-7d5, produced from non-transformed and transformed cells, may contribute to chronic inflammatory responses and development of ‘foamy’ cells by increased OLR1 expression that mediates increased oxLDL uptake. © 2017 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Prognostic factors in patients with disseminated nasopharyngeal carcinoma

Purpose. To identify the prognostic factors for patients with disseminated nasopharyngeal carcinoma (DNC). Material and methods. The study concerned 80 patients with DNC treated between 1995 2007. Forty of them received cisplatin based salvage chemotherapy, other patients were treated with palliative intent. Results. One-year overall survival rate in the whole group was 31%, and it was 55% for patients treated with a salvage chemotherapy and 7% for receiving palliative care (p=0,0001). Both uniand multivariate analysis demonstrated poor performance WHO/ECOG status and liver metastasis to be statistically significant for unfavorable outcomes. One-year overall survival rates for patients with WHO/ECOG values 0-1, and 2-3 were 50% and 10% respectively (p=0,0005). Liver metastasis decreased one-year overall survival from 34% to 10% (p=0,0009). There was no significant impact on overall survival of the other studied factors as age, gender, dissemination free interval, number of metastases and prior chemotherapy. Conclusions. Patients with DNC, free of liver metastasis and having a good performance status present the most favorable outcome. This group of patients may benefit from an aggressive salvage chemotherapy.
of Respiratory Infections Antimicrobial Stewardship in Hospitalized Patients with Respiratory Infections : Ten-Year Experience from the Robley Rex Louisville VA Medical Center

Antibiotic stewardship has been defined as coordinated interventions designed to improve and measure the appropriate use of antibiotic agents. This is accomplished by promoting the selection of the optimal antibiotic drug regimen including dosing, duration of therapy, and route of administration [1]. Successful implementation of antimicrobial stewardship programs has been associated with several benefits. These include improved patient outcomes, reduced adverse events including Clostridium difficile infection (CDI), decreased antibiotic resistance, and resource optimization such as decreased length of stay and cost of care. As a result of this, The Joint Commission, a United States not-for-profit organization dedicated to improving quality and effectiveness in healthcare, now requires an antimicrobial stewardship program (ASP) for hospital accreditation and certification. Additionally, in 2016, The Infectious Disease Society of America (IDSA) released national guidelines on implementing an ASP [2].
PHYSIOLOGICAL AND BIOCHEMICAL MANIFESTATIONS OF SALICYLIC ACID IN RICE UNDER WATER STRESS CONDITION

Salicylic acid (SA) is a naturally occurring plant hormone of phenolic nature that has diverse effects on tolerance to abiotic stresses. It may act as endogenous signal molecule responsible for inducing abiotic stress tolerance in plants, especially water stress. An experiment was therefore, conducted with an aim to assess the role of exogenously applied SA in water stress tolerance of four different rice varieties. The pot culture was laid out in a completely randomized design (CRD) with three replications. Varieties were subjected to water stress at vegetative stage by withholding water application. The study revealed that moisture stress at vegetative stage is highly detrimental to most of the physiological and biochemical traits investigated in the current research. Drought caused a massive reduction in the basic physiological processes measured in terms of photosynthetic rate, stomatal conductance, transpiration rate, and chlorophyll stability index, but contrastingly, caused noticeable increase in proline accumulation. Foliar application of 100 ppm SA improved the plant growth by increasing the above stated parameters which were reduced due to moisture stress and helped the plants to overcome the adverse effects of water stress. The present finding envisaged that SA improved the drought tolerance of all the four rice cultivars particularly the sensitive ones. Therefore, it may be used as an ameliorant to alleviate the negative effect of drought injury in rice.
Wisconsin Card Sorting Test Manual – Revised and Expanded

Correlation between intelligence test score and executive function measures. Archives Wisconsin Card Sorting Test manual: Revised and expanded. Odessa. The Wisconsin Card Sorting Test (WCST) was the most commonly used task Although the examiner did not provide instructions prior to or during the performance of the task, Wisconsin Card Sorting Test manual: revised and expanded. Wisconsin card sorting tests manual revised and expanded. Amsterdam short-term memory test: a new procedure for the detection of feigned memory deficits.
Recovering Multiple Error Correction Codes in Memory Applications

Currently, faults suffered by SRAM memory systems have increased due to the aggressive CMOS integration density. Thus, the probability of occurrence of single (SCUs) or multiple-cell upsets (MCUs) augments. One of the main causes of MCUs in space applications is cosmic radiation. A common solution is the use of error correction codes (ECCs). Nevertheless, when using ECCs in space applications, they must achieve a good balance between error coverage and redundancy, and their encoding/decoding circuits must be efficient in terms of area, power, and delay. Different codes have tolerate MCUs. For instance, Matrix codes use Hamming codes and parity checks in a bi-dimensional layout to correct and detect some patterns of MCUs. Recently presented, column (CLC) has been designed to tolerate MCUs in space applications. CLC is a modified Matrix code, based on extended Hamming codes and parity checks. Nevertheless, a common property of these codes is the high redundancy introduce present a series of new lowredundant ECCs able to correct MCUs with reduced area, power, and delay overheads. Also, these new codes maintain, or even improve, memory error coverage with respect to Matrix and CLC codes.
CLOUDE : RESEARCH ON MINING USING IR TECHNOLOGY Dr .

one builds a theory that explains internal operational principles of the approach, and defines the operations by specifying constraints that should be glad by the approach. The second level deals with the conclusion of the approach in associate in nursing abstract approach. One should choose an illustration for the input and for the expected output of the approach, Associate in degrees to specify associate degree formula for the transformation from input to output. The alternatives of illustration and formula are closely tied on. There generally exist many alternative representations. For a given illustration, there are many gettable algorithms. A illustration Associate in degree associate degree formula got to be chosen so as that blessings of the illustration area unit fully exploited by the formula and, at constant time, the disadvantages of the illustration area unit avoided. The third level deals with the physical realization of the approach. The devices that physically notice a technique may not be distinctive. The advances in technologies imply that constant technique is additionally enforced all over again with the invention of recent physical devices. Keywords— Cloud computing, Data mining, IR
Optimal Capacitor Placement and Sizing in Radial Distribution System

Shunt capacitors are used for reactive power compensation to maintain voltage in a distribution system. The aim of the problem is to find an optimal location and size of capacitor to install on a distribution system. Determination of capacitor size is an optimization problem and the goal is to minimize overall cost of power loss as well as cost of shunt capacitors simultaneously while satisfying constraints. In this paper, capacitor placement is carried out using a Loss Sensitivity Factor method and the solution of capacitor sizing problem is achieved using Goal Attainment method. Optimization problem is solved with the help of MatLab and load flow is carried out using MiPower software.
Immediate effects of spinal manipulation in pain and global joint mobility in patients with chronic nonspecific low back pain

Objective: The aim of this study was to analyze the immediate effects of applying a manipulative intervention on chronic non-specific back pain and increasing global joint mobility. Method: A cross-sectional, randomized, single-blind study was carried out, consisting of 19 women aged between 18 and 55 years old, separated into two groups: Experimental Group (EG = 10) and Control Group (CG=9). The evaluation consisted of a physical examination, Rolland Morris questionnaire, fingertip-to-floor test, Visual Analogue Scale (VAS), and pressure algometry (L5) before and after the manipulative intervention. The EG was submitted to five vertebral manipulations, two in the bilateral pelvis region, one in the middle thoracic region (T5-T7) and two in the bilateral cervical region at the C3 level. The CG was submitted to two placebos manipulative techniques, being positioned in right and left lateral decubitus position for 10 seconds each, in the same position of global pelvic manipulation, but without the manipulative impulse (thrust). Results: The results were statistically significant in the EG in the reduction of sensation of pain (p<0,001) and the increase of overall joint mobility (p<0,05) when comparing pre and post intragroup moments. There were no statistically significant differences in relation to pain threshold evaluated in pressure algometry. Conclusion: It is concluded that a manipulative intervention is able to reduce the pain and to increase the global mobility immediately after its accomplishment.
jmbReview Immunomodulatory Potential of Weissella cibaria in Aged C 57 BL / 6 J Mice

Aging is a complex process that negatively affects immunological function. The process of aging leads to gradual decline of the immune response, resulting in increased susceptibility to infectious diseases, impaired responses to vaccination, and increased chronic inflammatory diseases and cancer [1, 2]. These biological phenomena mainly occur in the adaptive immune system, which regulates humoral (B cell) and cellular (T cell) immune responses. In particular, a decrease in T cell number and function is an important factor in immunosenescence [3]. These changes in immune cells increase the susceptibility to autoimmune, chronic, and infectious diseases. To improve health in elderly and aging animals, developments in research and materials for immune enhancement or immunomodulation in the elderly have actively been made in recent years [4-6]. Probiotics are defined as living microbial additives that show beneficial health effects on the host animal by improving the balance of the intestinal microflora [7]. Lactic acid bacteria are the most frequently used probiotics and are widely known for their beneficial effects, such as anti-inflammatory, anticarcinogenic, antimutagenic, immunostimulatory, and cholesterol-lowering properties [8]. Probiotics have been shown to improve mechanisms of the Received: August 9, 2017 Revised: September 13, 2017 Accepted: September 17, 2017
Gettering impurities from crystalline silicon by phosphorus diffusion using a porous silicon layer

The possible benefits of phosphorus-based gettering applied to crystalline silicon wafers have been evaluated. The gettering process is achieved by forming porous silicon (PS) layers on both sides of the Si wafers. The PS layers were formed by the stain-etching technique, and phosphorus diffusion using liquid POCl3-based source was done on both sides of the Si wafer. The realized phosphorus/PS/Si/PS/phosphorus structure undergoes a heat treatment in an infrared furnace under an O2/N2 controlled atmosphere. This heat treatment allows phosphorus to diffuse throughout the PS layer and to getter eventual metal impurities towards the phosphorus doped PS layer. The gettering effect was evaluated using four probe points, Hall effect measurements and the light beam induced current (LBIC) technique. These techniques enable to measure the density and the mobility of the majority carrier and the minority carrier diffusion length (Ld) of the Si substrate. We noticed that the best gettering is achieved at 900 1C for 90min of heat treatment. After gettering impurities, we found an apparent enhancement of the mobility and the minority carrier diffusion length as compared to the reference substrate. r 2004 Elsevier B.V. All rights reserved.
Chapter 17 : Approaches to Measuring Cultural Diversity in Recreation

Measuring cultural diversity in recreation has become an important topic because of the increasing coverage of and interest in ethnicity and cross-cultural aspects of recreation. Introducing theories and methods from established disciplines other than leisure studies/recreation and park studies is necessary to understand this important issue. In this article, we first define recreation and examine different aspects/domains of recreation cross-culturally. To examine different domains of recreation cross-culturally, we need to have an unambiguous cultural definition as a basis to measure cultural variations. If the definition of culture contains cultural content (e.g., language, religion, family structure, cultural values), then we can specifically examine the influence of cultural content on recreation with various methods. We discuss different methods of measuring culture, emphasizing cultural consensus analysis to estimate the level of within-group or intracultural agreement. We also stress the issue of examining the homogeneity of ethnic groups as “real groups” from a scientific perspective. Finally, we describe approaches to measuring between-group or intercultural variations.