Miracle-dz/UniFAR-FTUs huggingface dataset:
Brucella serology in abattoir workers.

BACKGROUND Brucellosis is an occupational hazard with those particularly at risk either living in close proximity with animals or handling them. It is a public health problem in developing countries with adverse health implications both for animals and human beings as well as economic implications for individuals and communities. The Objectives were to estimate the seroprevalence of brucellosis among abattoir workers of Lahore District and to determine the association of brucellosis with nature of job of the workers. METHODS Data was collected in April 2008. It was a cross-sectional study in which four main slaughterhouses in Lahore were included. The slaughterhouse workers were divided into seven strata based on their nature of job: meat sellers, slaughterers, animal keepers, drivers, cleaners, loaders and vets/paravets. A total of 360 such workers were selected using stratified random sampling technique. Sampling frames for different strata were prepared and from each frame, proportionate numbers, were selected through simple random method using random number tables. Data was obtained using a questionnaire. Additionally blood samples were collected and analyzed for anti-Brucella Immunoglobulin G (IgG) using enzyme-linked immunosorbent assay (ELISA) technique. RESULTS The seroprevalence of anti-Brucella IgG was found to be 21.7%. A statistically significant difference was observed between the immune status of the respondents and their nature of job (p = 0.005), age groups (p = 0.013), and duration of job (p = 0.003). CONCLUSION The disease is an important public health problem in Pakistan. The disease can be prevented in the slaughterhouse workers through the use of personal protective devices. Public health authorities should educate the general public regarding prevention of the disease with specific emphasis on people working in slaughterhouses.
Breast Cancer Risk from Different Mammography Screening Practices

Abstract Mammography screening is an accepted procedure for early detection of breast tumors among asymptomatic women. Since this procedure involves the use of X rays, it is itself potentially carcinogenic. Although there is general consensus about the benefit of screening for older women, screening practices differ between countries. In this paper radiation risks for these different practices are estimated using a new approach. We model breast cancer induction by ionizing radiation in a cohort of patients exposed to frequent X-ray examinations. The biologically based, mechanistic model provides a better foundation for the extrapolation of risks to different mammography screening practices than empirical models do. The model predicts that the excess relative risk (ERR) doubles when screening starts at age 40 instead of 50 and that a continuation of screening at ages 75 and higher carries little extra risk. The number of induced fatal breast cancers is estimated to be considerably lower than derived from epidemiological studies and from internationally accepted radiation protection risks. The present findings, if used in a risk-benefit analysis for mammography screening, would be more favorable to screening than estimates currently recommended for radiation protection. This has implications for the screening ages that are currently being reconsidered in several countries.
Iterative algorithm for parameter identification of Hammerstein systems with two-segment nonlinearities

This paper deals with parameter identification of Hammerstein systems having two-segment polynomial nonlinearities. The application of a simple decomposition technique and using switching sequences provide a special form of a Hammerstein model that is linear-in-parameters. This model is used in an iterative algorithm, enabling simultaneous estimation of all of the model parameters. To demonstrate the feasibility of the identification method, more illustrative examples are included.
High dose adenosine for suboptimal myocardial reperfusion after primary PCI: A randomized placebo‐controlled pilot study

Objectives: This study was designed to investigate the influence of high dose intracoronary adenosine on persistent ST‐segment elevation after primary percutaneous coronary intervention (PCI). Background: After successful PCI for acute myocardial infarction 40–50% of patients show persistent ST‐segment elevation indicating suboptimal myocardial reperfusion. Adenosine has been studied to ameliorate reperfusion and is frequently used in a variety of doses, but there are no prospective studies to support its use for treatment of suboptimal reperfusion. Methods: We conducted a blinded, randomized, and placebo‐controlled study with high dose intracoronary adenosine in 51 patients with <70% ST‐segment resolution (STRes) after successful primary PCI. All patients were treated with stents and abciximab. Results: Immediately after adenosine, significantly more patients showed optimal (>70%) STRes compared with placebo (33% versus 9%, P < 0.05). Mean STRes was higher after adenosine (35.4% versus 23.0%, P < 0.05). In addition, TIMI frame count was significant lower (15.7 versus 30.2, P < 0.005), Myocardial Blush Grade was higher (2.7 versus 2.0, P < 0.05) and resistance index was lower in the adenosine group (0.70 versus 1.31 mm Hg per ml/min, P < 0.005). Conclusions: Intracoronary adenosine accelerates recovery of microvascular perfusion in case of persistent ST segment elevation after primary PCI. © 2007 Wiley‐Liss, Inc.
The Role of Multicellular Aggregation in the Survival of ErbB2-positive Breast Cancer Cells during Extracellular Matrix Detachment*

Background: Cancer cells evade death caused by extracellular matrix (ECM)-detachment to facilitate metastasis. Results: ErbB2-expressing cancer cells form aggregates during ECM-detachment that promote survival signaling through EGFR. Conclusion: Multicellular aggregation in ErbB2 positive cancer cells promotes survival by preventing EGFR degradation. Significance: Disrupting aggregation or inhibiting EGFR may be effective strategies to eliminate ErbB2-expressing cancer cells during ECM-detachment. The metastasis of cancer cells from the site of the primary tumor to distant sites in the body represents the most deadly manifestation of cancer. In order for metastasis to occur, cancer cells need to evade anoikis, which is defined as apoptosis caused by loss of attachment to extracellular matrix (ECM). Signaling from ErbB2 has previously been linked to the evasion of anoikis in breast cancer cells but the precise molecular mechanisms by which ErbB2 blocks anoikis have yet to be unveiled. In this study, we have identified a novel mechanism by which anoikis is inhibited in ErbB2-expressing cells: multicellular aggregation during ECM-detachment. Our data demonstrate that disruption of aggregation in ErbB2-positive cells is sufficient to induce anoikis and that this anoikis inhibition is a result of aggregation-induced stabilization of EGFR and consequent ERK/MAPK survival signaling. Furthermore, these data suggest that ECM-detached ErbB2-expressing cells may be uniquely susceptible to targeted therapy against EGFR and that this sensitivity could be exploited for specific elimination of ECM-detached cancer cells.
Accuracy and Latency of Judgment of Facial Expressions of Emotions

The aim of the experiment was to study the relation between accuracy of judgment of facial expressions of emotions and time for judgment. The results for 34 college students confirmed previous data showing high performance in identification of all emotions, although there were some important differences between emotions. Also, times for judgment were longer for the emotions which were more difficult to identify.
Peroxidation Potential and Antioxidant Activity of Serum in Patients with Diabetes Mellitus and Myocard Infarction

Endogen malondialdehyde (MDA), diene conjugate levels, the susceptibility to copper-induced lipid peroxidation and antioxidant activity of serum were determined in patients with atherosclerotic diseases such as diabetes mellitus and myocard infarction. Lipid peroxidation susceptibility and antioxidant activity did not change, however, an increase in endogen MDA and diene conjugate levels was observed in serum of these patients. These results indicate the presence of oxidative stress in diabetes mellitus and myocard infarction.
Dissecting Damages: An Empirical Exploration of Sexual Harassment Awards

My empirical study first replicates and then extends a prior preliminary empirical study by Cass Sunstein and Judy Shih of sexual harassment damages awards. It covers a comprehensive set of 232 cases in which plaintiffs won some positive amount of compensatory damages from state and federal, trial and appellate court decisions from 1982‐2004 (published either in official reporters or solely on Westlaw). Contrary to Sunstein and Shih’s finding, my analysis of these data reveals a consistent, and statistically significant, positive relationship between punitive and compensatory damages (at least in cases where punitive damages are awarded). My new empirical study then employs dependent variables that, in my view, are more theoretically and statistically sound than those employed by Sunstein and Shih and others who have focused exclusively on the relationship between punitive and compensatory damages: total combined damages (i.e., all compensatory and punitive damages), and what I term “outrage” damages, or combined noneconomic compensatory and punitive damages. My empirical results, using these new dependent variables, essentially confirm Sunstein and Shih’s conclusions regarding the irrelevance of variables pertaining to the nature and severity of harassment. What my study reveals as crucial predictive factors, by contrast, are factors pertaining to damages limitations. My study highlights that these factors—including the
MEN1 Is a Melanoma Tumor Suppressor That Preserves Genomic Integrity by Stimulating Transcription of Genes That Promote Homologous Recombination-Directed DNA Repair

ABSTRACT Multiple endocrine neoplasia type 1 is a familial cancer syndrome resulting from loss-of-function mutations in the MEN1 gene. We previously identified the tumor suppressor MEN1 as a gene required for oncogene-induced senescence in melanocytes, raising the possibility that MEN1 is a melanoma tumor suppressor. Here we show that MEN1 expression is lost in a high percentage of human melanomas and melanoma cell lines. We find that melanocytes depleted of MEN1 are deficient in homologous recombination (HR)-directed DNA repair, which is accompanied by increased nonhomologous end-joining activity. Following DNA damage, MEN1 levels increase as a result of phosphorylation by the DNA damage kinase ATM/ATR. Most importantly, we show that MEN1 functions by directly stimulating the transcription of several genes, including BRCA1, RAD51, and RAD51AP1, that encode proteins involved in HR. MEN1 and its coactivator, the mixed-lineage leukemia histone methyltransferase, are recruited to the BRCA1, RAD51, and RAD51AP1 promoters by estrogen receptor 1, resulting in increased histone H3-lysine 4 trimethylation and transcription. Collectively, our results indicate that MEN1 is a melanoma tumor suppressor that functions by stimulating the transcription of genes involved in HR-directed DNA repair.
Quantum Modeling of Electronic Charge Density in Warm Dense Matter

Warm dense matter plasmas can be produced by high-energy optical or free-electron X-ray lasers, Z-pinch X-ray sources, and nuclear detonations. These plasmas are the basis of inertial confinement fusion efforts at National Ignition Facility. The ab initio quantum modeling of warm dense aluminum (Al) plasmas is performed. We present several images of electronic charge density taken from investigations of structural optimization of Al atoms in warm dense plasma.
Complete Genome Sequence of Anoxybacillus flavithermus TNO-09.006, a Thermophilic Sporeformer Associated with a Dairy-Processing Environment

ABSTRACT Spores of thermophilic spore-forming bacteria are a common cause of contamination in dairy products. We isolated the thermophilic strain Anoxybacillus flavithermus TNO-09.006 from a milk-processing plant, and we report the complete genome of this isolate consisting of a single chromosome of 2.65 Mb.
The relationship between attachment style and postpartum depression

Although an increasing number of studies show an association between adult attachment style and mood disorders, the relationship between adult attachment style and depression associated with childbirth is largely unknown. This study investigated the association between women’s attachment style, postpartum depression (PPD), and other risk factors. During the 32nd week of pregnancy, 84 women were interviewed using the Attachment Style Interview. Participants also completed self-report questionnaires about reaction to pregnancy, family relationships, current life stresses, and symptoms of depression and anxiety. At one-month postpartum, they were evaluated for postpartum depressive symptoms using the Mini-International Neuropsychiatric Interview. Eighty-two women completed the second self-report questionnaires and were evaluated for PPD. The data of 76 women were eligible for analysis. PPD was present in 21%. An insecure attachment style was significantly related to depression. A multiple logistic regression analysis showed significant effects for insecure attachment, social economic status, and antenatal depression on PPD. Adding the insecure attachment style factor to the logistic model that predicted PPD increased the area under the curve to 0.87 (95% CI .77–.98; p < .05). The inclusion of attachment styles in assessments of perinatal depressive disorders could improve screening and the design of interventions.
An extended calculation model for shadowing loss caused by a moving human body in 60GHz WLAN

60GHz has been attracting significant attentions for ultra-broadband WLAN applications because 9GHz wide spectrum is available for unlicensed use on a world-wide basis. However, 60GHz has some drawbacks such as significant shadowing loss caused by a moving human body and large free space loss. To develop anti-shadowing techniques in 60GHz, it is required to characterize features of shadowing loss caused by a moving human body and develop a calculation model for performance evaluation of countermeasures against the shadowing loss. This paper describes an extended calculation model for shadowing loss caused by a moving human body in 60GHz WLAN and calculated results are compared with experimental results to confirm its validity.
An efficient linear time algorithm for scan chain optimization and repartitioning

Proposes a linear-time algorithm for post-placement scan chain optimization that works efficiently on large designs and that allows user-specified tradeoffs between runtime and solution quality. This algorithm is also efficiently applied on scan chain partitioning. Presents repartitioning algorithm that takes advantage of the linear-time scan chain optimization algorithm presented in the first part. The idea is simply to connect all the scan flipflops of all the scan chains together in a new chain. Then the algorithm optimizes this new chain and splits it in individual chains of the size of the initial chains. Later it assigns individual chains to their closest scan primary input/output pair.
A SPECTRAL SEQUENCE APPROACH TO NORMAL FORMS

Normal forms for vector elds and Hamiltonians at equilibria have a long history, an extensive literature, and a continuing appeal for researchers (e.g., see the references in [Mur1], [Sa1]). These entities have been treated in terms of completions of graded Lie algebras for at least 40 years [C], and more recently, following [B], in terms of actions of a graded subgroups acting on that Lie algebra. The group action context allows for a very simple description of the normal form problem: nd the orbit representatives which in some sense are the smallest. Baider characterized such elements in terms of a decomposition of the Lie algebra involving the image of the action and a complement; the minimal representative of an element is the one which lies entirely in the part that cannot be killed by the group action, and that representative is unique [B]. It has been known for quite some time that the standard methods for computing normal forms in the graded Lie algebra setting are related to spectral sequence calculations (see Arnol'd [A] for the case of singularities; Sanders and Murdock [Sa1], [Mur1] for the case of vector elds). Speci cally, in [Sa1] Sanders showed how one could interpret the normal form algorithm in terms of a minor variation of the standard spectral sequence of a ltered module with a compatible grading (also see [Sa2]). These spectral sequences provide some valuable information about the normal form but do not seem to play a major role in the actual calculations. Here we generalize the normal form algorithm to situations not covered by [B] and use a di erent approach to construct spectral sequences indexed by the elements `. This approach allows
A Grid-Connected Single-Phase Transformerless Inverter Controlling Two Solar PV Arrays Operating Under Different Atmospheric Conditions

A grid-connected single-phase transformerless inverter that can operate two serially connected solar photovoltaic (PV) subarrays at their respective maximum power points while each one of them is exposed to different atmospheric conditions is proposed in this paper. As two subarrays are connected in series, the number of serially connected modules within a subarray is reduced to half. Reduction in the number of serially connected PV modules within a subarray leads to an overall improvement in the magnitude of power that can be abstracted from a subarray while the modules of the subarray are exposed to varied atmospheric conditions. The topological structure of the inverter ensures that the common mode voltage does not contain high-frequency components, thereby reducing the magnitude of leakage current involved with the solar panels well within the acceptable limit. An in-depth analysis of the scheme along with the derivation of its small signal model has been carried out. Detailed simulation studies are performed to verify its effectiveness. A 1-kW laboratory prototype of the scheme has been fabricated. Detailed experimental validations have been carried out utilizing the prototype to confirm the viability of the proposed scheme.
Delirium Improvement with Mianserin Suppositories in Cancer Patients

Delirium is a significant problem in palliative medicine, and its proper management and prevention is extremely important. In our cancer center, mianserin suppositories have been included in the hospital formulary and are prescribed for cancer patients who have dysphagia; however, previous studies have shown only limited data on the effect of mianserin suppositories. Therefore, in this study, we compared the therapeutic effect of mianserin suppositories with mianserin tablets for improvement of delirium. Subjects were 66 cancer patients who had received either mianserin suppositories or mianserin tablets for delirium at our cancer center between April 2013 and March 2015. Delirium was evaluated using the Intensive Care Delirium Screening Check list (ICDSC). The improvement rates of delirium for 7 days were compared between the two groups using Fisher’s exact test. The dose of mianserin was 30-60 mg/day (median dose 30mg/day) in the suppository group (n=31) and 10-60 mg/day (median dose 20mg/day) in the tablet group (n=35). The improvement rates of delirium during the 7-day test period were 71.0% in the suppository group and 62.9% in the tablet group. There was no significant difference. (P=0.60) Considering the results of this study, mianserin suppositories have an equal delirium improvement effect compared with mianserin tablets. These findings also suggest that mianserin suppositories can be effectively used to improve delirium in patients with dysphagia.
Real-time calculation of a limiting form of the Renyi entropy for detection of subtle changes in scattering architecture

In an earlier studies we reported on the application of Renyi entropy, If (r), r ≪ 2, for the detection of precancerous lesions, by detection subtle changes in backscattered waveforms f(t) that occured as targeted nanoparticles slowly accumulated near the lesion. In contrast, the signal energy, defined as the sum of squares of the over the same moving window, was unable to detect this change (as was conventional B-mode imaging). Although the computational effort to obtain the result precluded its clinical application with currently available equipment, the study raised the possibility of further sensitivity improvements by using values of r closer to the limiting value of 2, where If (r) approaches infinity. The current study demonstrates that by extracting the asymptotic form of If (r) as r → 2 there is no loss of sensitivity. However, the resulting algorithm is must faster than previous approaches and has an operation count that is suitable for implementation in a real-time imaging system.
Cholinergic modulation of excitatory synaptic input integration in hippocampal CA1

During theta rhythm, the timing of inputs to hippocampal CA1 from the perforant path (PP) of the entorhinal cortex and the Schaffer collaterals (SCs) from individual CA3 pyramidal neurons can vary within an individual theta period. Importantly, during theta rhythms these interactions occur during elevated acetylcholine concentrations. Thus, I examined the effect that PP inputs have on SC inputs in hippocampal CA1 during cholinergic receptor activation. To do this I measured the impact that a single electrical stimulus of the stratum lacunosum‐moleculare (SLM, which contains the PP) had on excitation evoked by stimulation of the stratum radiatum (SR, which contains the SC) using voltage‐sensitive dye imaging, field excitatory postsynaptic potentials and whole cell patch clamping in rat hippocampal brain slices. My data showed that SLM stimulation one half a theta cycle or less (25–75 ms) before SR stimulation resulted in the summation of excitatory events in SR and SP of hippocampal CA1. The summation was unaffected by cholinergic receptor activation by carbachol. SLM stimulation one theta cycle (150–225 ms) preceding SR stimulation significantly suppressed excitatory events measured in SR and SP. This SLM stimulus inhibition of SR‐driven excitatory events was augmented by carbachol application. The carbachol effect was blocked by atropine and SLM‐driven suppression of excitatory events was blocked by the GABAB receptor antagonist CGP 54626. SR field EPSP slopes were unaffected by SLM prepulses. Carbachol increased the probability of SR input to drive action potential firing in CA1 pyramidal neurons, which was inhibited by SLM prepulses (150–225 ms). Together these data provide important information regarding the integration of inputs in hippocampal CA1 during theta rhythms. More specifically, SR inputs can be differentially gated by SLM feedforward inhibition at varying temporal intervals within a theta cycle.
Radiative decays of dynamically generated charmed baryons

In this work we study the radiative decay of dynamically generated J{sup P}=(1{sup -}/2) charm baryons into the ground state J{sup P}=(1{sup +}/2) baryons. Since different theoretical interpretations of these baryonic resonances and, in particular, of the {Lambda}{sub c}(2595), give different predictions, a precise experimental measurement of these decays would be an important step for understanding their nature.