Miracle-dz/UniFAR-FTUs huggingface dataset:
Conjugated linoleic acid (CLA) induces human adipocyte delipidation: autocrine/paracrine regulation of MEK/ERK signaling by adipocytokines

The abbreviations used are: ACBP, acyl-CoA binding protein; ACC, acetyl-CoA carboxylase; BCA, bicinchoninic acid; aP2, adipocyte-specific fatty acid-binding protein; C/EBPα, CAAT/enhancer binding protein alpha; CLA, conjugated linoleic acid; ERK, extracellular signal-related kinase; FA, fatty acid; FITC, fluorescein; GLUT4, insulindependent glucose transporter 4; GPCR, G protein-coupled receptor; GPDH, glycerol-3phosphate dehydrogenase; HBSS, Hanks balanced salt solution; HSL, hormone sensitive lipase; IL-6, interleukin-6; IL-8, interleukin-8; JNK, c-Jun-NH2-terminal kinase; IBMX, isobutylmethylxanthine; LA, linoleic acid; LSC, liquid scintillation counting; LPL, lipoprotein lipase; ORO, Oil red O; MIP-1α, macrophage inflammatory protein-1α; MAPK, mitogen activated protein kinase; MCP-1, monocyte chemotactic protein-1; MEK, mitogen-activated protein kinase kinase ; PTX, pertussis toxin; PKA, protein kinase A; SV, stromal vascular; TBP, TATA binding protein; TG, triglyceride; TBS, Tris-buffered saline; TBS-T, TBS Tween 20, TNFα, tumor necrosis factor alpha; TNFR, TNFα receptor; TZD, thiazolidinedione.
A new era in the control of tuberculosis

New approaches to control tuberculosis (TB) worldwide are needed. In particular, new tools for diagnosis and new biomarkers are required to evaluate both pathogen and host key elements of the response to infection. Non-sputum based diagnostic tests, biomarkers predictive of adequate responsiveness to treatment, and biomarkers of risk of developing active TB disease are major goals. Here, we review the current state of the field. Although reports on new candidate biomarkers are numerous, validation and independent confirmation are rare. Efforts are needed to reduce the gap between the exploratory up-stream identification of candidate biomarkers, and the validation of biomarkers against clear clinical endpoints in different populations. This will need a major commitment from both scientists and funding bodies.
Approximation from Shift-Invariant Subspaces of L sup 2 (R sup d)

Abstract : A complete characterization is given of closed shift-invariant subspaces of which provide a specified approximation order. When such a space is principal (i.e., generated by a single function), then this characterization is in terms of the Fourier transform of the generator. As a special case, we obtain the classical Strang-Fix conditions, but without requiring the generating function to decay at infinity. The approximation order of a general closed shift-invariant space is shown to be already realized by a specifiable principal subspace.
management of chronic systematic review and meta-analysis

Opioids are the recommended form of analgesia for patients with persistent cancer pain and regular dosing ‘by the clock’ is advocated in many international guidelines on cancer pain management. The development of sustained release opioid preparations has made regular dosing easier for patients. However, patients report that the intensity and impact of their cancer pain varies considerably day to day, and many try to find a trade-off between acceptable pain control and impact of cognitive (and other) adverse effects on daily activities. In acute care settings, (eg postoperative) as needed dosing and other opioid sparing approaches have resulted in better patient outcomes compared with regular dosing. The aim of this study was to determine whether regular dosing of opioids was superior to as needed dosing for persistent cancer pain. We systematically searched for randomised controlled trials that directly compared pain outcomes from regular dosing of opioids with as needed dosing in adult cancer patients. We identified 4347 records, 25 RCTs meet the inclusion criteria, nine were included in the review and 7 of these included in meta-analysis. We found no clear evidence demonstrating superiority of regular dosing of opioids compared with as needed dosing in persistent cancer pain and regular dosing was associated with significantly higher total opioid doses. There was, however, a paucity of trials directly answering this question and low-quality evidence limits the conclusions that can be drawn. It is clear that further high-quality clinical trials are needed to answer this question and to guide clinical practice.
User acceptance of HIV TIDES--Tailored Interventions for Management of Depressive Symptoms in persons living with HIV/AIDS.

OBJECTIVE The Tailored Interventions for management of DEpressive Symptoms (TIDES) program was designed based on social cognitive theory to provide tailored, computer-based education on key elements and self-care strategies for depressive symptoms in persons living with HIV/AIDS (PLWHAs). DESIGN AND MEASUREMENT Based on an extension of the Technology Acceptance Model (TAM), a cross-sectional design was used to assess the acceptance of the HIV TIDES prototype and explore the relationships among system acceptance factors proposed in the conceptual model. RESULTS Thirty-two PLWHAs were recruited from HIV/AIDS clinics. The majority were African American (68.8%), male (65.6%), with high school or lower education (68.7%), and in their 40s (62.5%). PARTICIPANTS spent an average of 10.4 minutes (SD = 5.6) using HIV TIDES. The PLWHAs rated the system as easy to use (Mean = 9.61, SD = 0.76) and useful (Mean = 9.50, SD = 1.16). The high ratings of behavior intention to use (Mean = 9.47, SD = 1.24) suggest that HIV TIDES has the potential to be accepted and used by PLWHAs. Four factors were positively correlated with behavioral intention to use: perceived usefulness (r = 0.61), perceived ease of use (r = 0.61), internal control (r = 0.59), and external control (r = 0.46). Computer anxiety (r = -0.80), tailoring path (r = 0-.35) and depressive symptoms (r = -0.49) were negatively correlated with behavioral intention to use. CONCLUSION The results of this study provide evidence of the acceptability of HIV TIDES by PLWHAs. Individuals are expected to be empowered through participating in the interactive process to generate their self-care plan. HIV TIDES enables information sharing about depression prevention and health promotion and has the potential to reframe the traditional patient-provider relationship.
Scattering of conformal higher spin (cid:12)elds

: We develop a formalism for describing the most general notion of tree-level scattering amplitudes in 4d conformal higher spin theory. As conformal higher spin (cid:12)elds obey higher-derivative equations of motion, there are many distinct on-shell external states which may contribute to their scattering, some of which grow polynomially with time, leading to ill-de(cid:12)ned amplitudes. We characterize the set of admissible scattering states which produce (cid:12)nite tree amplitudes, noting that there are more such states than just standard massless higher spins obeying two-derivative equations of motion. We use conformal gravity as a prime example, where the set of scattering states includes the usual Einstein graviton and a ‘ghost’ massless spin 1 particle. An extension of the usual spinor helicity formalism allows us to encode these scattering states e(cid:14)ciently in terms of ‘twistor-spinors’. This leads to compact momentum space expressions for all (cid:12)nite tree-level 3-point amplitudes of conformal higher spin theory. While some of these 3-point amplitudes vanish (including all those with only standard two-derivative higher spin external states), there are many others which are non-vanishing. We also comment on the generalization to scattering of conformal higher spins in AdS 4 .
Operation of Reheat Steam Temperature Control Concept in Sub Critical Boiler: Operational Review Practices and Methodology

In subcritical boilers, spray water system and feed water flow are applied to control the superheated steam temperature. Meanwhile, for reheat steam temperature control, many methods are being adopted namely burner tilt, gas recirculation, and excess air and steam bypass as primary control and feed water is envisaged as an emergency control. In a large boiler operation, the boiler is operated in sliding pressure mode the cold reheat steam temperature is higher compared to constant pressure operation. To ensure the correct temperature control for reheat steam with high pressure, the right method and sufficient mechanism operating the boiler is required. In fact, spray is not used for reheat steam temperature control because the boilers are designed for constant pressure operation since the spray quantity required will be large for an impact on plant heat rate. The boilers used for this study were operated under sliding pressure mode; hence, reheat steam temperature control by spray is a common practice in subcritical boiler operations. This paper dealt with the advantages and disadvantages of using spray by looking at boiler performance for RH steam temperature control in lieu of other control mechanisms.
Common and distinct brain networks of autoscopic phenomena NeuroImage: Clinical

Objective: Autoscopic phenomena (AP) are illusory own body reduplications characterized by the visual perception of a second own body in extrapersonal space, and include three main forms: autoscopic hallucination (AH), heautoscopy (HAS) and out-of-body-experience (OBE). Past research showed that lesions were heteroge- neously distributed and affected many different brain regions within and across patients, while small case series suggested that AP lesions converge in temporo-parietal and parieto-occipital cortex. As only few studies inves- tigated each form of AP separately, it remains unknown whether the three AP are characterized by common and distinct brain mechanisms. Methods: Here, we applied lesion network analysis in 26 neurological AP patients and determined their common and distinct functional connectivity patterns. Results: We report that all localize to a single common brain network at the bilateral temporo-parietal junction, further associated with specific patterns of functional connectivity, defining each type of AP. OBE resulted from a brain network connected to bilateral angular gyrus, right precuneus, and right inferior frontal gyrus, differing from AH with a brain network connected to bilateral precuneus, inferior temporal gyrus, and cerebellum. HAS resulted from a brain network connected to left inferior frontal gyrus, left insula and left parahippocampus. Conclusion: The present data identify the temporo-parietal junction as the common core region for AP and show that each form of AP recruits additional specific networks, associated with different sensorimotor and self-related sub-networks.
E ﬀ ects of Powder Feed Rate on Formation of Fully Equiaxed β Grains in Titanium Alloys Fabricated by Directed Energy Deposition

: A near β titanium alloy, Ti5Al2Sn2Zr4Mo4Cr, was fabricated by directed energy deposition (DED) with di ﬀ erent powder feed rates to investigate the formation of fully equiaxed β grains. A two-dimensional numerical model was developed to investigate the thermal conditions of the molten pool. Experimental results showed that the formation of an epitaxial cellular structure at the bottom of the molten pool is almost unavoidable. An increase in the powder feed rate produces a moderate thermal condition and promotes the formation of equiaxed grains in a single cladding layer. However, it could not guarantee the formation of a fully equiaxed microstructure in a block sample. From a low to high powder feed rate, fully columnar, mixed equiaxed–columnar, and fully equiaxed microstructures were obtained. Grain morphology was also a ﬀ ected by the remolten process. Increasing the powder feed rate reduced the remolten depth and broke the continuity of the epitaxial cellular structure, leading to di ﬀ erent grain morphologies.
CMAR_A_278570 12895..12903

1Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, People’s Republic of China; 2Information Center, Shandong Mental Health Center, Jinan, Shandong 250014, People’s Republic of China Objective: TMED2 is a member of the transmembrane emp24 domain (Tmed)/p24 protein family, which is significantly upregulated in breast cancer, ovarian cancer and other tumour tissues. The purpose of this study was to investigate the expression of TMED2 in MM cell lines and its effect on the biological behaviour of MM cell lines. Methods: Real-time quantitative PCR (RT-qPCR) was used to detect the expression of TMED2 in MM cell lines, including MM.1S and RPMI 8226 cells, and lentivirus vectormediated TMED2 gene silencing was used to further study the effect of the downregulation of TMED2 expression on cell viability, the cell cycle, and apoptosis. Results: Based on the RT-qPCR results, the expression of the TMED2 mRNA was increased in the MM cell lines MM.1S and RPMI 8226 compared with endogenous control GAPDH. The expression of the TMED2 mRNA was substantially reduced after transfection of the shRNA targeting TMED2 (shTMED2) in both MM cell lines. The CCK-8 assay showed significant decreases in the viability of MM.1S and RPMI 8226 cells, suggesting that the TMED2 gene plays an important role in the proliferation of these two cell lines. The cell cycle of MM.1S and RPMI 8226 cells was substantially altered by shTMED2, as evidenced by the increased number of cells in G1 phase and decreased number of cells in S and G2/M phases. The FACS analysis revealed a significant increase in the apoptosis of MM.1S and RPMI 8226 cells due to the increased activity of Caspase 3/7, suggesting that the TMED2 gene is significantly related to the apoptosis of these two cell lines. Conclusion: Based on these results, TMED2 may play an important role in the pathogenesis of MM. This novel study may contribute to further investigations of useful biomarkers and potential therapeutic targets in patients with MM.
Scattering of Electromagnetic Waves: Advanced Topics

Preface. Two-Dimensional Random Rough Surface Scattering Based on Small Perturbation Method. Kirchhoff Approach and Related Methods for Rough Surface Scattering. Volume Scattering: Cascade of Layers. Analytic Wave Theory for a Medium with Permittivity Fluctuations. Multiple Scattering Theory for Discrete Scatterers. Quasi-Crystalline Approximation in Dense Media Scattering. Dense Media Scattering. Backscattering Enhancement. Index.
Principle of Water Electrolysis and Recent Progress of Cobalt, Nickel, and Iron-based Oxides for Oxygen Evolution Reaction

: Water electrolysis that results in green hydrogen is the key process towards a circular economy. The availabilities of the sustainable electricity and oxygen evolution reaction (OER) electrocatalyst are the main bottlenecks of the process for large-scale green hydrogen production. A broad range of OER electrocatalysts has been explored to decrease the overpotential and boost the kinetics of this sluggish half-reaction. Co, Ni, and Fe-based catalysts have been considered to be potential candidates to replace noble metals due to their tunable 3d electron configuration and spin state, versatility in the terms of crystal and electronic structures as well as abundance in nature. This review provides some basic principles of water electrolysis, key aspects of OER, and significant criteria for the development of the catalysts. It provides also some insights on recent advances of Co, Ni, and Fe-based oxides and a brief perspective on green hydrogen production and the challenges of water electrolysis.
TSLP Expression: Analysis with a ZsGreen

Thymic stromal lymphopoietin (TSLP) is a type I cytokine that plays a central role in induction of allergic inﬂammatory responses. Its principal targets have been reported to be dendritic cells and/or CD4 T cells; epithelial cells are a principal source. We report in this study the development of a reporter mouse (TSLP-ZsG) in which a ZsGreen (ZsG)-encoding construct has been inserted by recombineering into a bacterial artiﬁcial chromosome immediately at the translation initiating ATG of TSLP. The expression of ZsG by mice transgenic for the recombinant BAC appears to be a faithful surrogate for TSLP expression, particularly in keratinocytes and medullary thymic epithelial cells. Limited ZsG and TSLP mRNA was observed in bone marrow–derived mast cells, basophils, and dendritic cells. Using the TSLP-ZsG reporter mouse, we show that TNF- a and IL-4/IL-13 are potent inducers of TSLP expression by keratinocytes and that local activation of Th2 and Th1 cells induces keratinocyte TSLP expression. We suggest that the capacity of TSLP to both induce Th2 differentiation and to be induced by activated Th2 cells raises the possibility that TSLP may be involved in a positive feedback loop to enhance allergic inﬂammatory conditions. The Journal of Immunology , 2015, 194: 000–000.
MEASUREMENT OF CHRONIC HEPATITIS B ASSOCIATION WITH QUALITY OF LIFE: A CROSS SECTIONAL STUDY

Background: The health-related qualities of life (HRQOL) of people, suffering from chronic hepatitis B is (CHB) infection is estimated by some research studies. Aim: The objective of the current studies was to assess the healthrelated quality of life of a patient at various phases of CHB infection. To estimate the causes of HRQOL were also included in the objective of the study. Methods: This research study was organized in Jinnah Hospital, Lahore from November 2018 to June 2019. All the people interviewed were adult CHB patients and were 520 in total. The interview was taken by means of chronic liver disease Questionnaire (CLDQ), structured Questionnaire and the SF-36 Health Survey Version 2 (SF-36v2). Out of 520 patients interviewed, impaired liver function, hepatocellular carcinoma HCC and cirrhosis were observed in 102, 123 and 139 patients respectively. Moreover, 156 patients were normal. In order to assess the causal factors of HRQOL, multiple linear regression was performed. To check the dissimilarity between each CHB group and population norms regarding SF-6D health preferences Values and SF36v2 scores, T-test was employed. ANOVA was employed to check similarity and difference of mean SF-36v2 scores, CLDQ scores, and SF-6D health preferences among SHB groups. Results: the results indicated the factors connected with poorer HRQOL were younger age, psychological comorbidity, female, anti-viral treatment, advanced stage of CHB illness and bilirubin level. Moreover, as compared to population norm, remarkably lower SF-36v2 scores were noticed in the CHB patients the value of SF6D of CHB patients impaired live function was 0.745, with cirrhosis 0.701, with uncomplicated disorder 0.755 and with HCC was 0.720, on the other hand, 0.787 was value in population norm, which was remarkably lower. Conclusion: In those studies, that are Cost-Effie, the quality-adjusted life years (QALYS) for CHB patients can be passed through results. The results concluded that on HRQOL, CHB infection had a negative impression. Along with CHB disease progression, there observed a progressive decline in health preference values.
The Aquila Digital Community The Aquila Digital Community

Cloud computing is a “new frontier” in the world of computing. One of the cloud architectures widely used is the Hadoop running environment. Hadoop consists of many parts—including MapReduce, TaskTrackers, and JobTrackers. Right now, there is no fault-tolerance for JobTrackers in Hadoop. This paper analyzes four different distributed hash algorithms (Pastry, Tapestry, CAN, and Chord) that could be implemented inside Hadoop to improve JobTracker fault-tolerance. We recommend Chord as the best suited for integration and improvement of Hadoop.
Family Profiles in Retailing: A Novel Algorithm Combining PU Learning and Feature Selection

In the era of personalized marketing, leveraging data analysis to recommend tailored products has become the key to building competitive advantage. As an essential aspect of customer information, family profiles can boost the inference of personalized needs. Combining positive and unlabeled learning and feature selection techniques, this paper designs a novel and flexible family profiling algorithm that tags target customers based on unlabeled transaction data. The empirical evaluation shows that our proposed algorithm outperforms other traditional algorithms regarding the recall rate of positive examples. This study also explores the balance between the effectiveness and efficiency of the proposed algorithm and compares the effects of different profile characteristics on the algorithm performances. The results of this study can be utilized to help retailers economically and efficiently predict customers’ family profiles, thereby reaching their target audiences and achieving better marketing performance
Recent Treatment Strategies for Advanced Gastric Cancer: Future Perspectives on Multimodality Therapy

extended lymphadenectomy, which included the para-aortic lymph nodes, had been performed to improve the cure rate for advanced gastric cancer in Japan. The Japan Clinical Oncology Group (JCOG) conducted a randomized controlled trial that validated the benefit of this extended lymph node dissection compared with standard D2 lymphadenectomy (JCOG9501) [8,9]. As a result, although the safety of extended lymphadenectomy was proven, the survival benefit could not be demonstrated. Many surgeons might be disappointed in these unfavorable results, which implied that the surgical potential in the treatment strategy for advanced gastric cancer is limited.
Toll-Like Receptor 2 Activation by Chlamydia trachomatis Is Plasmid Dependent, and Plasmid-Responsive Chromosomal Loci Are Coordinately Regulated in Response to Glucose Limitation by C. trachomatis but Not by C. muridarum (cid:1) loss on plaque size, infectivity, glycogen

We previously demonstrated that plasmid-deﬁcient Chlamydia muridarum retains the ability to infect the murine genital tract but does not elicit oviduct pathology because it fails to activate Toll-like receptor 2 (TLR2). We derived a plasmid-cured derivative of the human genital isolate Chlamydia trachomatis D/UW-3/Cx, strain CTD153, which also fails to activate TLR2, indicating this virulence phenotype is associated with plasmid loss in both C. trachomatis and C. muridarum. As observed with plasmid-deﬁcient C. muridarum , CTD153 displayed impaired accumulation of glycogen within inclusions. Transcriptional proﬁling of the plasmid-deﬁcient strains by using custom microarrays identiﬁed a conserved group of chromosomal loci, the expression of which was similarly controlled in plasmid-deﬁcient C. muridarum strains CM972 and CM3.1 and plasmid-deﬁcient C. trachomatis CTD153. However, although expression of glycogen synthase, encoded by glgA , was greatly reduced in CTD153, it was unaltered in plasmid-deﬁcient C. muridarum strains. Thus, additional plasmid-associated factors are required for glycogen accumulation by this chlamydial species. Furthermore, in C. trachomatis , glgA and other plasmid-responsive chromosomal loci (PRCLs) were transcriptionally responsive to glucose limi- tation, indicating that additional regulatory elements may be involved in the coordinated expression of these candidate virulence effectors. Glucose-limited C. trachomatis displayed reduced TLR2 stimulation in an in vitro assay. During human chlamydial infection, glucose limitation may decrease chlamydial virulence through its effects on plasmid-responsive chromosomal genes.