Miracle-dz/UniFAR-FTUs huggingface dataset:
INTERNATIONAL SCHOOL LEADERSHIP IN MALAYSIA: EXPLORING TEACHERS’ PERSPECTIVES ON LEADING IN A CULTURALLY DIVERSE ENVIRONMENT

International schools present a promising setting in the exploration of leadership in culturally diverse organisations. Due to heightened global interconnectivity, the increasing number of international schools in the Asia Pacific region leads to the evergrowing formation of multicultural learning environments. Aside from being one of the countries with the largest number of international school students in Southeast Asia, Malaysia offers a socio-culturally distinct venue for understanding the organisational dynamics of international schools in a heterogeneous society. Hence, this study primarily aims to present the perspectives of international school teachers on the practices and programmes employed by school leaders with respect to cultural diversity. Taking the viewpoints of school teachers, this case study focuses on how school leaders perform in the midst of the culturally diverse environment of an international school in Malaysia. Thirteen teachers from a prominent international school in Kuala Lumpur were purposefully selected to participate in semi-structured interview sessions. To substantiate the responses from the interviews, five teachers from the same school participated in a focus group discussion. The data from the individual interviews and focus group discussion were triangulated with observation field notes and document analysis. The collated data were thematically analysed using Atlas.ti. The emerging themes revolve around the following: leadership practices with respect to cultural diversity; programmes and policies promoting cultural awareness; and, leadership effects on the school community. Having students and teachers coming from different socio-cultural backgrounds, international schools pose both opportunities and challenges for leadership. Guided by the findings of this study, international school leaders and teachers may design their curriculum and initiate new co-curricular or organisational programmes promoting cultural diversity to benefit students and teachers. More than identifying leadership practices and institutionalised programmes in managing cultural differences, this study calls for further introspection and action to harness the potentials of leadership in promoting harmony in diversity for societal development.
Incisional Negative Pressure Wound Therapy Dressing in Total Joint Arthroplasty: what is the evidence? A Meta-Analysis

Background The purpose of this study is to evaluate whether incisional negative pressure therapy dressing (iNPWT) has an advantage over conventional wound dressing (CWD) on wound healing for patients with total joint arthroplasty (TJA) Methods We searched the electronic databases including PubMed, The Cochrane Library, EMBASE via Ovid SP, Medline via Ovid SP, to screening published randomized controlled trials and high-quality cohort studies reported that incisional negative pressure therapy dressing applied in hip and knee arthroplasty. We analyzed the overall complications, major and minor complications, dressing changes, infection rate, and the rate of reoperation. The relevant data was analyzed by RevMan5.3. Results Six studies met our criteria, and included 1405 incisions in 971 participants with total joint arthroplasty which were randomized either to incisional negative pressure therapy dressing group (n=578) or to conventional wound dressing group (n=827) . The risk for developing a minor complication between two groups was not significantly different (risk ratio [RR] 0.58, p =0.40) and for major complication was also not significantly different (RR 0.71, p =0.39). In terms of dressing changes, the iNPWT was fewer than the control group ( P <0.05). The effect of rate of infection and reoperation was not significantly different (RR 0.65, p =0.27). Conclusions For patients underwent TJA, applying iNPWT may be associated with fewer dressing change, which maybe mean less exudation. There was no significant difference on the rate of infection and reoperation, and experiencing either minor or major complications between participants in whom iNPWT versus CWD were used for wound. However, more high-quality randomized or non-randomized controlled trials with larger sample sizes and cost-effectiveness analysis are required.
Correct Expression of the Material Derivative in Continuum Physics

The material derivative is important in continuum physics. This Letter shows that the expression $\frac{d }{dt}=\frac{\partial }{\partial t}+(\bm v\cdot \bm \nabla)$, used in most literature and textbooks, is incorrect. The correct expression $ \frac{d (:)}{dt}=\frac{\partial }{\partial t}(:)+\bm v\cdot [\bm \nabla (:)]$ is formulated. The solution existence condition of Navier-Stokes equation has been proposed from its form-solution, the conclusion is that "\emph{The Navier-Stokes equation has a solution if and only if the determinant of flow velocity gradient is not zero, namely $\det (\bm \nabla \bm v)\neq 0$. }"
Risk Communication for Viral Hepatitis Management Among Migrants

The burden of viral hepatitis is high with huge mortality and morbidity on human population. The increasing migration of people from areas highly prevalent of viral hepatitis poses a unique threat to the healthcare systems of the host nations. The deficient universal standards for screening, vaccination, and treatment of viral hepatitis have therefore made the burden of chronic liver disease and hepatocellular carcinoma to increase among migrant populations globally. This study examines the role of risk communication in managing viral hepatitis among migrants at the different levels of pre-departure phase, travel phase, destination phase, interception phase and the return phase. The study concluded on the need for concerted effort by national governments to develop a national communication policy with comprehensive risk communication strategies on viral hepatitis management among migrants.
The perspectives and experiences of physiotherapists and general practitioners in the use of the STarT Back Tool Tool: A review and meta- synthesis

Background: Chronic low back pain is associated with disability and work absence. Stratified primary care management of acute low back pain using a prognostic screening tool (STarT Back Tool, SBT) triages people with LBP into targeted treatment groups, matched to their level of risk of chronicity. The SBT was designed for use in the health service in the United Kingdom (UK) where it has been shown to improve clinical outcomes, patient satisfaction, and reduce treatment costs and time off work. Successful implementation of the SBT in health care outside the UK is dependent on the health practitioners who will use it and the healthcare system in which they work. Gaining health practitioners’ perspectives on the SBT is an important step in effective implementation. Methods: A computerised search of qualitative literature was conducted across seven databases in March 2021 using keywords to identify studies that investigate the perspectives of physiotherapists and general practitionners on the use of the SBT in primary health care. Study quality was assessed using the CASP tool. Data were coded and analysed using reflexive thematic analysis. Results: Eight articles met the inclusion criteria and included the views of general practitioners and physiotherapists from primary health care settings from four countries. Three overarching themes were created from the data, the first ‘making it work’, identifies factors that may influence implementation and continued use of the SBT in clinical practice. The second ‘will I do it? ’, captured potential consequences of adopting the SBT and the third ‘it’s all about the patient’ emphasised how the SBT may affect patients and their potential reactions to risk stratification and matched treatments.Conclusions: Physiotherapists and general practitioners found using the SBT frequently enhanced their practice. General practitioners did express concerns about time constraints and the potential for the SBT to undermine their clinical experience. Findings from this study will inform modifications to contextualise the tool to each healthcare environment.
Utilization of Whey for Red Pigment Production by Monascus purpureus in Submerged Fermentation

Various biotechnological approaches have been employed to convert food waste into value-added bioproducts through fermentation processes. Whey, a major waste generated by dairy industries, is considered an important environmental pollutant due to its massive production and high organic content. The purpose of this study is to investigate the effect of different fermentation parameters in simultaneous hydrolysis and fermentation (SHF) of whey for pigment production with Monascus purpureus. The submerged culture fermentation parameters optimized were type and pretreatment of whey, pH, inoculation ratio, substrate concentration and monosodium glutamate (MSG) concentration. Demineralized (DM), deproteinized (DP), and raw whey (W) powders were used as a substrate for pigment production by simultaneous hydrolysis and fermentation (SHF). The maximum red pigment production was obtained as 38.4 UA510 nm (absorbance units) at the optimized condition of SHF. Optimal conditions of SHF were 2% (v/v) inoculation ratio, 75 g/L of lactose as carbon source, 25 g/L of MSG as nitrogen source, and fermentation medium pH of 7.0. The specific growth rate of M. purpureus on whey and the maximum pigment production yield values were 0.023 h−1 and 4.55 UAd−1, respectively. This study is the first in the literature to show that DM whey is a sustainable substrate in the fermentation process of the M. purpureus red pigment.
Geopolymers based on mechanically activated fly ash blended with dolomite

This study reports the effect of natural dolomite addition to fly ash and the mechanical activation of this blend on the geopolymerization process. Dolomite was replaced with fly ash at 1, 3, 5, and 10 wt. %. Geopolymers were synthesized at ambient temperature using NaOH solution as an alkaline agent. The geopolymerization process, reactivity of the raw material, compressive strength, and microstructure were studied using X-ray diffraction, Fourier-transform infrared spectroscopy, thermogravimetry, and scanning electron microscopy. It was shown that blending fly ash with dolomite and mechanical activation improved the geopolymer strength, especially during the early age of curing. For geopolymers prepared using a 90% fly ash + 10% dolomite blend cured for 7 d, the strengths were 8.2-, 2.3-, and 1.4-fold higher than those for geopolymers prepared using 100% FA for 30 s, 180 s, and 400 s milling times, respectively. A simple method for evaluating the increments of mechanical activation, carbonate additives, and the synergistic effect in the increase in the compressive strength of the composite geopolymer is proposed.
Whole Genome Sequencing in single CTC improves clinical outcome in Her-2 negative breast cancer patients

Backgroud: Tumor tissues are usually highly heterogeneous and difficult to characterize which could mislead treatment strategy. Circulating tumor cells (CTCs) represent the most active and invasive tumor cells. This study retrospectively investigated the feasibility of individualized treatment of breast cancer patients based on genome sequencing of single cell CTC. Twenty-four CTCs were identified in three patients with breast cancer. For each patient, one polyploid CTC was captured and on which the whole genome sequencing (WGS) was performed. Based on the histopathological Her-2 status in tumor tissue and the HER2 gene status in WGS results of CTC, we adjusted treatment strategies, and monitored disease progression. Results: Patient ID1 and ID2 are with Her-2 protein overexpression in primary tumors and HER2 gene amplification in the DNA of CTCs. In patient ID3, histological examination of primary tumor and liver metastases revealed Her-2 negative, but the WGS analysis of CTC showed that the HER2 gene was amplified. After adjusting treatment by adding Her-2 inhibitors according to the results of CTC sequencing, the liver metastases and pleural effusion were significantly reduced 2 month later, CTC number and ctDNA burden were decreased, and 18-month progression-free survival (PFS) was recorded. In addition, some potential therapeutic targets and mutations in drug-resistant genes were found. Conclusions: The results of CTC sequencing effectively guided treatment of a patient with HER2 gene amplification in CTC but with Her-2 negative on tumor tissue. CTC sequencing is useful in resolving the heterogeneity of tumors and providing precision medicine for patients.
Improvement of alzheimer disease diagnosis accuracy using ensemble methods

Nowadays, there is a significant increase in the medical data that we should take advantage of that. The application of the machine learning via the data mining processes, such as data classification depends on using a single classification algorithm or those complained as ensemble models. The objective of this work is to improve the classification accuracy of previous results for Alzheimer disease diagnosing. The Decision Tree algorithm with three types of ensemble methods combined, which are Boosting, Bagging and Stacking. The clinical dataset from the Open Access Series of Imaging Studies (OASIS) was used in the experiments. The experimental results of the proposed approach were better than the previous work results. Where the Random Forest (Bagging) achieved the highest accuracy among all algorithms with 90.69%, while the lowest one was Stacking with 79.07%. All these results generated in this paper are higher in accuracy than that done before.
Bayesian Inference of Parameters in Power System Dynamic Models Using Trajectory Sensitivities

We propose an analytically tractable Bayesian method to infer parameters in power system dynamic models from noisy measurements of bus-voltage magnitudes and frequencies as well as active- and reactive-power injections. The proposed method is computationally appealing as it bypasses the large number of system model simulations typically required in sampling-based Bayesian inference. Instead, it relies on analytical linearization of the nonlinear system differential-algebraic-equation model enabled by trajectory sensitivities. Central to the proposed method is the construction of a linearized model with the maximum probability of being (closest to) the actual nonlinear model that gave rise to the measurement data. The linear model together with Gaussian prior leads to a conjugate family where the parameter posterior, model evidence, and their gradients can be computed in closed form, markedly improving scalability for large-scale power systems. We illustrate the effectiveness and key features of the proposed method with numerical case studies for a three-bus system. Algorithmic scalability is then demonstrated via case studies involving the New England 39-bus test system.
In Search of the Active Sites for the Selective Catalytic Reduction on Tungsten-Doped Vanadia Monolayer Catalysts supported by TiO2

Tungsten-doped vanadia-based catalysts supported on anatase TiO2 are used to reduce hazardous NO emissions through the selective catalytic reduction of ammonia, but their exact atomistic structure is still largely unknown. In this computational study, the atomistic structure of mixed tungsta-vanadia monolayers on TiO2 support under typical operating conditions has been addressed by periodic density functional theory calculations. The chemical environment has been taken into account in a grand-canonical approach. We evaluate the stable catalyst structures as a function of the oxygen chemical potential and vanadium and tungsten concentrations. Thus we determine structural motifs of tungsta-vanadia/TiO2 catalysts that are stable under operating conditions. Furthermore, we identify active sites that promise high catalytic activity for the selective catalytic reduction by ammonia. Our calculations reveal the critical role of the stoichiometry of the tungsta-vanadia layers with respect to their catalytic activity in the selective catalytic reduction.
Higher-Order Conceptual Model for Labyrinth Seal Flutter

A simple non-dimensional model to describe the flutter onset of two-fin straight labyrinth seals [1] is extended to account for non-isentropic flow perturbations. The isentropic relationship is replaced by the more general integral energy equation of the inter-fin cavity. A new expression for the Corral & Vega stability criterion is derived which is very consistent with the previous model in the whole design space of the seal but for torsion centers located in the high-pressure side close to the seal. The new model formally depends on more dimensionless parameters since the existing parameter grouping of the previous model does not hold anymore, but this dependency is weak in relative terms. The model blends the limit where the discharge time of the inter-fin cavity is much longer than the vibration period, and the flow is nearly isentropic, and the opposite limit, where the perturbations are isothermic, gracefully. A few numerical examples obtained using a three-dimensional linearized frequency domain solver are included to support the model and show that the trends are correct but the body of the numerical work will be presented in a separated article. The matching between the work-per-cycle obtained with the model and frequency domain solver is good. It is shown that some weird trends obtained using linearized unsteady simulations are qualitatively consistent with the current model but not with the previous one [1]. The largest differences between the new and the previous model are seen when the seal is supported at the high-pressure side.
The DNA Repair Enzyme XPD Is Partially Regulated by PI3K/AKT Signaling in the Context of Bupivacaine-Mediated Neuronal DNA Damage

Bupivacaine, a local anesthetic widely used for regional anesthesia and pain management, has been reported to induce neuronal injury, especially DNA damage. Neurons employ different pathways to repair DNA damage. However, the mechanism underlying bupivacaine-mediated DNA damage repair is unclear. A rat neuronal injury model was established by intrathecal injection of (3%) bupivacaine. An in vitro neuronal injury model was generated by exposing SH-SY5Y cells to bupivacaine (1.5 mmol/L). Then, a cDNA plate array was used to identify the DNA repair genes after bupivacaine exposure. The results showed that xeroderma pigmentosum complementary group D (XPD) of the nuclear excision repair (NER) pathway was closely associated with the repair of DNA damage induced by bupivacaine. Subsequently, Western blot assay and immunohistochemistry indicated that the expression of the repair enzyme XPD was upregulated after DNA damage. Downregulation of XPD expression by a lentivirus aggravated the DNA damage induced by bupivacaine. In addition, phosphatidyl-3-kinase (PI3K)/AKT signaling in neurons was inhibited after exposure to bupivacaine. After PI3K/AKT signaling was inhibited, bupivacaine-mediated DNA damage was further aggravated, and the expression of XPD was further upregulated. However, knockdown of XPD aggravated bupivacaine-mediated neuronal injury but did not affect PI3K/AKT signaling. In conclusion, the repair enzyme XPD, which was partially regulated by PI3K/AKT signaling, responded to bupivacaine-mediated neuronal DNA damage. These results can be used as a reference for the treatment of bupivacaine-induced neurotoxicity.
Postoperative Management Strategy of Surgical Site Infection following Lumbar Dynesys Dynamic Internal Fixation

Aim To research the incidence of surgical site infection (SSI) following lumbar Dynesys dynamic internal fixation and its management strategy. Methods We retrospectively analyzed all cases of lumbar Dynesys dynamic internal fixation performed from January 2010 to December 2019, and the data from patients with SSI were collected. The observational indicators included the incidence of SSI, general information of the patients, surgical details, inflammatory indicators, pathogenic bacteria, and treatment. SSI was defined as both early infection and delayed infection, and the cases were divided into Groups A and B, respectively. The relevant indicators and treatment were compared between the two groups. Results A total of 1125 cases of lumbar Dynesys dynamic internal fixation were followed up. Twenty-five cases of SSI occurred, and the incidence of SSI was 2.22% (25/1125). There were 14 cases of early infection (1.24%) and 11 cases of delayed infection (0.98%). Fourteen cases of early infection occurred 12.3 ± 8.3 days postoperatively (3–30), and 11 cases of delayed infection occurred 33.3 ± 18.9 months postoperatively (3–62). The inflammatory indicators of Group A were significantly higher than those of Group B (all P < 0.05), except for procalcitonin. The main infection site in Group A was located on the skin and subcutaneous tissue and around the internal instrument, while the main infection site in Group B was around the internal instrument. The main treatment for Group A was debridement and implant replacement, and the main treatment for Group B was implant removal. Summary. The incidence of SSI following lumbar Dynesys dynamic internal fixation was 2.22%, the incidence of early SSI was 1.24%, and the incidence of delayed SSI was 0.98%. If the main infection site of early infection is in the incision, debridement should be the main treatment method; if the infection site is around the internal fixation, implant replacement is recommended on the basis of debridement. Once delayed infection is diagnosed, implant removal is suggested.
Plasma Fatty Acid Composition Was Associated with Apelin Gene Expression in Human Adipose Tissues

Background Apelin is an adipokine with an intermediatory role in obesity and insulin resistance, which can be modified by dietary intake. Aims In this study, we aimed to determine the association of the plasma fatty acid composition with apelin plasma concentration and gene expression in visceral (VAT) and subcutaneous (SAT) adipose tissues. Methods In this cross-sectional study, we recruited 179 patients aged 19-75 years who were candidates for elective surgery. Through the surgery, SAT and VAT were collected to measure apelin gene expression. Anthropometric measurements, fasting blood samples, and dietary intakes were collected before surgery. Free fatty acids (FFAs) in fasting whole plasma were measured using gas chromatography with flame ionization detection. Linear regression models were used to estimate standardized β (STZ β) showing the association of individual and total FFAs with apelin gene expression after adjustment for potential confounding variables. Results In multivariable analysis, we observed a significant positive association of total plasma free fatty acids (FFAs) (STZ β = 0.241, P = 0.006), saturated fatty acid (SFA) (STZ β = 0.336, P < 0.001), and monounsaturated fatty acid (MUFA) (STZ β = 0.313, P < 0.001) concentrations with apelin gene expression from VAT after controlling for age, sex, body mass index, homeostatic model assessment for insulin resistance (HOMA-IR), physical activity, and energy intake. In the SFA family, there was a direct association with plasma concentration of myristic acid (STZ β = 0.372, P < 0.001), pentadecanoic acid (STZ β = 0.252, P = 0.002), and heptadecanoic acid (STZ β = 0.407, P < 0.001) with apelin mRNA expression in VAT. There was no significant association between FFAs and apelin plasma concentration and SAT mRNA levels. Conclusions In conclusion, circulating plasma FFAs, SFA, and MUFA had a positive association with apelin gene expression in VAT. It seems that plasma fatty acid composition may regulate apelin gene expression in VAT.