Miracle-dz/UniFAR-FTUs huggingface dataset:
An Analytical Generalized Prandtl–Ishlinskii Model Inversion for Hysteresis Compensation in Micropositioning Control

Smart actuators employed in micropositioning are known to exhibit strong hysteresis nonlinearities, which may be asymmetric and could adversely affect the positioning accuracy. In this paper, the analytical inverse of a generalized Prandtl-Ishlinskii model is formulated to compensate for hysteresis nonlinearities of smart actuators. The generalized model was modified to ensure its continuity, and its validity in characterizing different hysteresis properties is briefly demonstrated by comparing the model responses with the measured data for the magnetostrictive, shape memory alloys (SMA), and piezo micropositioning actuators. Since the proposed generalized model is a mere extension of the analytically invertible classical Prandtl-Ishlinskii model, an inverse of the generalized model is formulated using the inverse of the classical model together with those of the envelope functions of the generalized play operator. The effectiveness of the inverse of the generalized model in compensating for the symmetric and asymmetric saturated hysteresis effects is subsequently investigated through simulations for a magnetostrictive and a SMA actuators, and through preliminary experiments performed on a piezo micropositioning stage. The simulation results suggest that the inverse of the generalized Prandtl-Ishlinskii model can be conveniently applied as a feedforward compensator to effectively mitigate the effects of the asymmetric and saturated hysteresis in magnetostrictive and SMA actuators. The experimental results further revealed that the proposed generalized analytical inverse model can be conveniently implemented as a real-time feedforward compensator to compensate for hysteresis nonlinearities of a piezo micropositioining stage.
Sensitivity of Searches for New Signals and Its Optimization

A frequentist definition of sensitivity of a search for new phenomena is discussed, that has several useful properties. It is based on completely standard concepts, is generally applicable, and has a very clear interpretation. It is particularly suitable for optimization, being independent of a-priori expectations about the presence of a signal, thus allowing the determination of a single set of cuts that is optimal both for setting limits and for making a discovery. Simple approximate formulas are given for the common problem of Poisson counts with background.
Targeted BSA mapping of Scmv1 and Scmv2 conferring resistance to SCMV using PstI/MseI compared with EcoRI/MseI AFLP markers

In a previous study, two chromosome regions (Scmv1 and Scmv2), conferring sugarcane mosaic virus (SCMV) resistance in maize, were enriched with EcoRI/MseI AFLP (Eco-AFLP) markers (methylation insensitive) by targeted bulked segregant analysis (tBSA). The objective of the present study was to further saturate these two regions with PstI/MseI AFLP (Pst-AFLP) markers (methylation sensitive) using the same tBSA approach, and to compare the genomic distribution of both Pst-AFLP and Eco-AFLP markers. Out of 470 PstI/MseI primer combinations screened, four Pst-AFLP markers were identified in the Scmv1 region (chromosome 6), and none in the Scmv2 region (chromosome 3). These Pst-AFLP markers were more closely linked to the Scmv1a gene than any of the Eco-AFLP markers, and could be useful for marker-assisted selection and even map-based cloning. In addition, Pst-AFLP and Eco-AFLP markers were dissimilarly distributed in both target regions. Pst-AFLP markers were equally distributed across both regions, while Eco-AFLPs were clustered in the Scmv2 region.
Document Representation and Its Application to Page Decomposition

Transforming a paper document to its electronic version in a form suitable for efficient storage, retrieval, and interpretation continues to be a challenging problem. An efficient representation scheme for document images is necessary to solve this problem. Document representation involves techniques of thresholding, skew detection, geometric layout analysis, and logical layout analysis. The derived representation can then be used in document storage and retrieval. Page segmentation is an important stage in representing document images obtained by scanning journal pages. The performance of a document understanding system greatly depends on the correctness of page segmentation and labeling of different regions such as text, tables, images, drawings, and rulers. We use the traditional bottom-up approach based on the connected component extraction to efficiently implement page segmentation and region identification. A new document model which preserves top-down generation information is proposed based on which a document is logically represented for interactive editing, storage, retrieval, transfer, and logical analysis. Our algorithm has a high accuracy and takes approximately 1.4 seconds on a SGI Indy workstation for model creation, including orientation estimation, segmentation, and labeling (text, table, image, drawing, and ruler) for a 2550/spl times/3300 image of a typical journal page scanned at 300 dpi. This method is applicable to documents from various technical journals and can accommodate moderate amounts of skew and noise.
Downregulation of Survivin Is Associated With Reductions in TNF Receptors' mRNA and Protein and Alterations in Nuclear Factor Kappa B Signaling in Urothelial Cancer Cells

Because survivin is selectively expressed in and associated with an unfavorable prognosis in transitional cell carcinoma of the bladder (TCC), we treated T-24 cells with survivin siRNA. Survivin siRNA treatment caused a profound decrease of survivin protein that was associated with decreased cell growth, a specific G2/M arrest and increased cytochrome c release. Microarray analysis of apoptosis genes showed that levels of 14/114 gene products were decreased after 72 hours treatment with survivin siRNA, including survivin, three TNF receptors, Akt, c-Abl, caspases and their related genes and Bcl-2 and NF-κB signaling related genes. TNFR1, pro-caspase-2 and Akt protein levels were decreased after survivin siRNA treatment for 48 and 72 hours. Downregulation of survivin causes changes in mitosis and apoptosis, which may be related to changes in TNF receptors and NF-κB signaling.
Cross-language Search: The Case of Google Language Tools

This paper presents a case study of Google Language Tools, especially its cross-language search service. Cross-language search integrates machine translation (MT) and cross-language information retrieval (CLIR) technologies and allows Web users to search and read pages written in languages different from their search terms. In addition to cross-language search, Google Language Tools provides various language support services to multilingual information access. Our study examines the functions of Google Language Tools and the performance of its cross-language search. The results and analysis show that Google Language Tools are useful for Web users. Its cross-language search service provides quality query translation while the automatic translation of result pages needs further improvement. The paper suggests that cross-language search could be used by different types of Web users. The authors also discuss the strategies and important issues with regard to implementing multilingual information access services for information systems.
Impact of highly active antiretroviral therapy on the incidence of visceral leishmaniasis in a French cohort of patients infected with human immunodeficiency virus.

The incidence of human immunodeficiency virus (HIV)-Leishmania coinfections in France was estimated on the basis of the French Hospital Database on HIV, and risk factors for the occurrence of visceral leishmaniasis (VL) were analyzed by a multivariate Cox model. VL was diagnosed in 165 of 55,626 HIV-infected patients followed since 1992. The incidence of VL decreased from 11.6+/-1.2 per 10,000 persons-years before 1996 to 6.3+/-0.7 per 10,000 persons-years after 1996, the year when highly active antiretroviral therapy (HAART) was initiated in France. The relative hazard (RH) for development of VL was higher in (1) intravenous drug users versus other transmission groups (RH=1.56; 95% CI, 1.13-2.15), (2) patients living in southern France versus those living in northern France (RH=3.36; 95% CI, 2.44-4.61), and (3) patients who had a CD4 cell count of </=50/mm(3) during their follow-up versus those who did not (RH=6.45; 95% CI, 4.27-9.75) but was lower in (4) patients who received antiretroviral therapy including >/=3 drugs versus those who did not (RH=0.41; 95% CI, 0.26-0.65). We found a significant decrease in the incidence of HIV-Leishmania coinfections after 1996, associated with the introduction of HAART in France.
Induction of Interleukin-8 Synthesis Integrates Effects on Transcription and mRNA Degradation from at Least Three Different Cytokine- or Stress-Activated Signal Transduction Pathways

ABSTRACT A hallmark of inflammation is the burst-like formation of certain proteins, initiated by cellular stress and proinflammatory cytokines like interleukin 1 (IL-1) and tumor necrosis factor, stimuli which simultaneously activate different mitogen-activated protein (MAP) kinases and NF-κB. Cooperation of these signaling pathways to induce formation of IL-8, a prototype chemokine which causes leukocyte migration and activation, was investigated by expressing active and inactive forms of protein kinases. Constitutively active MAP kinase kinase 7 (MKK7), an activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) pathway, induced IL-8 synthesis and transcription from a minimal IL-8 promoter. Furthermore, MKK7 synergized in both effects with NF-κB-inducing kinase (NIK). Activation of the IL-8 promoter by either of the kinases required functional NF-κB and AP-1 sites. While NIK and MKK7 did not affect degradation of IL-8 mRNA, an active form of MKK6, which selectively activates p38 MAP kinase, induced marked stabilization of the transcript and further increased IL-8 protein formation induced by NIK plus MKK7. Consistently, the MAP kinase kinase kinase MEKK1, which can activate NF-κB, SAPK/JNK, and p38 MAP kinases, most potently induced IL-8 formation. These results provide evidence that maximal IL-8 gene expression requires the coordinate action of at least three different signal transduction pathways which cooperate to induce mRNA synthesis and suppress mRNA degradation.
Dissociable effects of ultralow-dose naltrexone on tolerance to the antinociceptive and cataleptic effects of morphine

Ultralow-dose opioid antagonists augment the antinociceptive effect of morphine and block the development of tolerance to repeated morphine injections in rodents, but the effects are not reliably reproduced in humans. One explanation for this discrepancy is that preclinical studies of ultralow-dose antagonism in rodents generally use reflex-withdrawal tests of antinociception, which may be affected by cataleptic effects of morphine. We tested this hypothesis by examining whether ultralow-dose naltrexone alters the cataleptic effect of morphine or the development of tolerance to morphine-induced catalepsy. Rats (N=56) were randomly assigned to saline, morphine (10 mg/kg), cotreatments of morphine plus naltrexone (molar ratios of 1 000 000 : 1; 500 000 : 1; 100 000 : 1), or naltrexone-alone groups. Rats were injected with drug for 7 consecutive days; on each day, catalepsy and antinociception were assessed 30 and 60 min postinjection, using the bar and tail-flick tests, respectively. Ultralow-dose naltrexone (500 000 : 1) extended the antinociceptive effect of morphine within a session and attenuated the development of tolerance to the antinociceptive effect of morphine across sessions. Naltrexone alone had no effect on either test. These data show that the paradoxical effect of ultralow-dose naltrexone on antinociception is not the product of morphine-induced catalepsy, pointing to an important role for agonist–antagonist combinations in the clinical treatment of pain.
Design of Low-Profile Metamaterial-Loaded Substrate Integrated Waveguide Horn Antenna and Its Array Applications

A metamaterial-loaded substrate integrated wave-guide (SIW) horn antenna and its array application are researched in this communication. The mushroom-type metamaterial is placed in front of SIW horn aperture, and much improvement in impedance matching is achieved on a 1/ $20~\lambda _{0}$ -thickness substrate. Due to the backward wave generated by the metamaterial, backward endfire radiation pattern is observed for the proposed antenna. Experimental results indicate that a fractional impedance bandwidth of 10.6% is obtained for a fabricated prototype. Furthermore, a shunt four-element array and a monopulse four-element array are designed based on the novel SIW horn element to further enhance the radiation performance. Results show that performances of wide operating bandwidth, low profile, and backward endfire radiation pattern are maintained for the designed two arrays.
New Onset Depression Following Myocardial Infarction Predicts Cardiac Mortality

Objective: Studies investigating the effects of depression on mortality following myocardial infarction (MI) have produced heterogeneous findings. We report on a study investigating whether the timing of the onset of depression, with regard to the MI, affected its impact on subsequent cardiac mortality. Methods: Five hundred and eighty-eight subjects admitted following MI underwent assessments of cardiac status, cardiac risk factors, and noncardiac illness. We identified separately subjects who were depressed before their MI (pre-MI depression) and those who developed depression in the 12 months after MI (new-onset depression), using a standardized questionnaire and a research interview. Patients dying of cardiac cause were identified during 8-year follow-up using information from death certificates. Results: Multivariate predictors of cardiac death during follow-up included: greater age (hazards ratio (HR) = 1.06, p = . 007), previous angina (HR = 4.15, p < .0005), high Killip Class (HR = 2.21, p = .013), prescription of beta-blockers on discharge (HR = 0.37, p = .02), and new-onset depression (HR = 2.33, p = .038). Pre-MI depression did not convey any additional risk of cardiac mortality. Conclusion: We have shown increased cardiac mortality in patients who develop depression after suffering MI. Further observational studies need to separate pre- and post-MI depression if we are to determine underlying mechanisms by which depression is associated with mortality following MI. MI = myocardial infarction; CPK = creatine phosphokinase; ECG = electrocardiogram; WHO = World Health Organization; HADS = Hospital Anxiety and Depression Scale; ICD-10 = 10th version of the International Classification of Diseases; SCAN = schedule for assessment in neuropsychiatry; ACE Inhibitors = angiotensin converting enzyme inhibitors; CABG = coronary artery bypass graft; SD = standard deviation.
Comparative Performance Analysis of Speech Enhancement Methods

The implementation of Speech Enhancement using Spectral Subtraction method and Kalman Filtering method are presented here. Spectral subtraction mainly removes the background noise from noisy speech spectrum. Original speech is obtained by subtracting noise spectrum from noisy speech spectrum. The main disadvantage of spectral subtraction is the presence of musical noise in enhanced speech signal. Secondly, to filter out the background noise from the desired speech signal several speech filtering algorithms has been introduced in last few years. In this paper Kalman Filter for speech enhancement has been proposed. It is observed that spectral subtraction method is very efficient for noise elimination in high SNR condition but performance degrades with reduction in SNR. It is observed that Kalman Filter is efficient in reduction of noise particularly at low SNR conditions. The two designs are modelled using MATLAB for seven different noise types and the SNR are compared.
The effect of prior injections of lyophilized mouse tumor on the growth and transplantation of mouse tumors in rats.

Summary Tolerance of various degrees of primary subcutaneous grafts of mouse tumors was conferred on rats pretreated with suspensions of lyophilized mouse tumors of the same tumor strains. Inoculations of transplantable mouse tumors into rats resulted in tumors in 84 per cent of the treated rats. These tumors were all of considerable size (up to 6 × 5 cm.). Some of them regressed at intervals up to 42 days, while some persisted to the death of the animal. Untreated control rats of the same age and strain were resistant to grafts of the same mouse tumors. The mouse tumors grown in rats could be transplanted further from rat to rat for several passages, but only in treated rats. Tumors from different rat passages could be transplanted back into mice of the original strain. Tumors of the seventh rat-to-rat passage were still strain-specific for mice.
The impact of the viscosity variations of acidic solutions on enamel erosion

The objective of this in vitro study was to investigate the effects of viscosity changes of different acidic solutions on dental erosion. Bovine enamel samples (n = 240, Ø = 3 mm) were embedded in acrylic resin and were allocated to 30 groups (n = 8). Citric acid (CA) and phosphoric acid (PA) solutions at pH 2.5, 3, and 3.5 were prepared in de-ionized water (titratable acidity to pH 5.5: 31 ± 0.6 mmol OH(-)/l). The kinetic viscosities of the acidic solutions were adjusted to 1.5, 3, 6, 12, and 24 mm(2)/sec by the addition of hydroxypropyl cellulose (HPC) at different concentrations. Solutions were pumped over the enamel surface from a reservoir with a drop rate of 1 mL/min. Each specimen was eroded for 10 min at 20 °C. Erosion of enamel surfaces was measured by profilometry. Data were analyzed by analyses of variance and logarithmic regression analyses (p < 0.05). Enamel loss was dependent on viscosity, pH, and the kind of acid. The regression analyses showed that higher viscosity caused lower enamel erosion for both acids and all pH levels. Dental erosion is dependent not only on chemical factors of the acid, like pH and acid type, but also on acid viscosity. DOI: https://doi.org/10.1177/0022034512473115 Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-86320 Accepted Version Originally published at: Aykut-Yetkiner, A; Wiegand, A; Bollhalder, A; Becker, K; Attin, T (2013). Effect of acidic solution viscosity on enamel erosion. Journal of Dental Research, 92(3):289-294. DOI: https://doi.org/10.1177/0022034512473115 The impact of the viscosity variations of acidic solutions on enamel erosion Arzu AYKUT-YETKINER, Annette WIEGAND, Andrea BOLLHALDER, Klaus BECKER, Thomas ATTIN Arzu AYKUT YETKINER, Research Fellow, University of Zurich, Clinic for Preventive Dentistry, Periodontology and Cariology, Zurich, Switzerland, Assistant Professor, University of Ege, Faculty of Dentistry, Department of Pedodontics, Izmir, Turkey Annette WIEGAND, Associate Professor, University of Zurich, Clinic for Preventive Dentistry, Periodontology and Cariology, Zurich, Switzerland Andrea BOLLHALDER, Dental Student, School of Dentistry, University of Zurich Klaus BECKER, University of Zurich, Clinic for Preventive Dentistry, Periodontology and Cariology, Zurich, Switzerland Thomas ATTIN, Professor, Director, University of Zurich, Clinic for Preventive Dentistry, Periodontology and Cariology, Zurich, Switzerland word count: 195 Total word count: 2633 Total number of tables/figures: 4 Number of references: 31
Internet Research Emerald Article: An integrated e-recruitment system for automated personality mining and applicant ranking

Abstract Purpose – The purpose of this paper is to present a novel approach for recruiting and ranking jobapplicants in online recruitment systems, with the objective to automate applicant pre-screening.An integrated, company-oriented, e-recruitment system was implemented based on the proposedscheme and its functionality was showcased and evaluated in a real-world recruitment scenario.Design/methodology/approach – The proposed system implements automated candidate ranking,based on objective criteria that can be extracted from the applicant’s LinkedIn profile. What is more,candidate personality traits are automatically extracted from his/her social presence using linguisticanalysis. The applicant’s rank is derived from individual selection criteria using analytical hierarchyprocess (AHP), while their relative significance (weight) is controlled by the recruiter.Findings – The proposed e-recruitment system was deployed in a real-world recruitment scenario,and its output was validated by expert recruiters. It was found that with the exception of seniorpositions that required domain experience and specific qualifications, automated pre-screeningperformed consistently compared to human recruiters.Researchlimitations/implications – It was found that companies can increase the efficiency of therecruitment process if they integrate an e-recruitment system in their human resources managementinfrastructure that automates the candidate pre-screening process. Interviewing and backgroundinvestigation of applicants can then be limited to the top candidates identified from the system.Originality/value – To the best of the authors’ knowledge, this is the first e-recruitment system thatsupports automated extraction of candidate personality traits using linguistic analysis and rankscandidates with the AHP.Keywords Recruitment, Human resource management, Selection, Social networking sites,Data mining, Personality, E-recruitment, Personality mining, Recommendation systems,Analytic hierarchy processPaper type Research paper
Functional analyses of mouse ASK, an activation subunit for Cdc7 kinase, using conditional ASK knockout ES cells

ASK (activator of S phase kinase) is an activation subunit for mammalian Cdc7 kinase. We have generated mutant ES cell lines in which ASK can be conditionally inactivated. Upon loss of the ASK genes, the mutant ES cells rapidly cease cell growth. In keeping with its expected roles in activation of the essential S phase kinase, DNA synthesis is arrested and significant cell death is eventually induced in ASK‐deficient cells, demonstrating essential roles of ASK for viability of ES cells. Using these mutant cells, we have set up a system where ASK molecules can be functionally dissected. In keeping with previous results from yeasts, conserved motif‐M and motif‐C were shown to be essential for in vivo functions of ASK, whereas a long C‐terminal tail, found only in ASK‐related molecules in higher eukaryotes, is not required. Unexpectedly, the motif‐N, related to the BRCT motif and dispensable for viability in yeasts, is essential for the viability of ES cells. Further characterization reveals that motif‐N is required for the maximum phosphorylation of MCM in cells, whereas the autophosphorylation activity of Cdc7 is not significantly affected by its loss. These results may suggest that motif‐N of ASK may facilitate recruitment of substrates for Cdc7 kinase.
Automatic Path-Oriented Test Data Generation Using a Multi-population Genetic Algorithm

Automatic path-oriented test data generation is an undecidable problem and genetic algorithm (GA) has been used to test data generation since 1992. In favor of MATLAB, a multi-population genetic algorithm (MPGA) was implemented, which selects individuals for free migration based on their fitness values. Applying MPGA to generating path-oriented test data generation is a new and meaningful attempt. After depicting how to transform path-oriented test data generation into an optimization problem, basic process flow of path-oriented test data generation using GA was presented. Using a triangle classifier as program under test, experimental results show that MPGA based approach can generate path-oriented test data more effectively and efficiently than simple GA based approach does.