Miracle-dz/UniFAR-FTUs huggingface dataset:
Toll-Like Receptor 4 (TLR4) and AMPK Relevance in Cardiovascular Disease

Toll-like receptors (TLRs) are essential receptors of the innate immune system, playing a significant role in cardiovascular diseases. TLR4, with the highest expression among TLRs in the heart, has been investigated extensively for its critical role in different myocardial inflammatory conditions. Studies suggest that inhibition of TLR4 signaling pathways reduces inflammatory responses and even prevents additional injuries to the already damaged myocardium. Recent research results have led to a hypothesis that there may be a relation between TLR4 expression and 5' adenosine monophosphate-activated protein kinase (AMPK) signaling in various inflammatory conditions, including cardiovascular diseases. AMPK, as a cellular energy sensor, has been reported to show anti-inflammatory effects in various models of inflammatory diseases. AMPK, in addition to its physiological acts in the heart, plays an essential role in myocardial ischemia and hypoxia by activating various energy production pathways. Herein we will discuss the role of TLR4 and AMPK in cardiovascular diseases and a possible relation between TLRs and AMPK as a novel therapeutic target. In our opinion, AMPK-related TLR modulators will find application in treating different immune-mediated inflammatory disorders, especially inflammatory cardiac diseases, and present an option that will be widely used in clinical practice in the future.
OP-IJEJ180269 134..147

Background: The World Health organization (WHO) recommends that children engage in 60 min daily moderate-to-vigorous physical activity (dMVPA). Just half of children in the UK achieve these levels (with similarly low levels in other high-income countries). Thus, the dMVPA target is a focus of national obesity strategies. However, the potential impact of increased physical activity on prevalence and inequalities in childhood overweight is unknown. Using objective data from the Millennium Cohort Study ( 18 000 children born 2000–02) we simulated a series of hypothetical physical activity intervention scenarios: achievement of the target, and more realistic increases demonstrated in trials. Methods: Predicted probabilities of overweight and obesity (using measured heights and weights at age 11) were estimated in multinomial marginal structural models, adjusting for dMVPA (measured with accelerometers at age 7) and confounding. Inequalities were assessed according to household income quintiles [risk ratios (RRs) and risk differences (RDs)]. Intervention scenarios were simulated by re-estimating predicted probabilities of overweight/ obesity after manipulating (increasing) dMVPA by varying amounts, for different eligibility criteria and with varying uptake. Analyses included 6493 children with accelerometer data. Survey weights and multiple imputation addressed sampling design, attrition and item missingness. Results: In all, 27% children were overweight/obese, with relative and absolute inequalities in the expected direction; 51% children were achieving 60 min dMVPA, with those from the lowest income quintile achieving, on average, 3 min more dMVPA than those from the highest income quintile. A simulation of universal achievement of the dMVPA target reduced the prevalence of overweight/obesity to 22%, but increased relative inequalities (absolute VC The Author(s) 2018. Published by Oxford University Press on behalf of the International Epidemiological Association. 134 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com International Journal of Epidemiology, 2019, 134–147 doi: 10.1093/ije/dyy267 Advance Access Publication Date: 7 December 2018
NDT_A_333930 3205..3214

1Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China; 2Department of Cardiovascular Medicine, People’s Hospital Affiliated of Nanchang University, Jiangxi Provincial People’s Hospital, Nanchang, Jiangxi, People’s Republic of China; 3Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China
c-Kit - The Novel Receptor: Physiological Roles, Downstream Signaling and Implications in Cancer

The belief that adult mammalian heart lacks regenerative potential was challenged by the identification of c-kit positive Cardiac Progenitor Cells (CPCs) in the heart. SCIPIO; a phase I clinical trial; has shown that autologous c-kit positive CPCs improve cardiac function and quality of life when transplanted into ischemic heart disease patients. c-Kit is a type III receptor tyrosine kinase and a common stem cell antigen. Stem Cell Factor (SCF) is the only known ligand for c-kit. Activation of this membrane bound receptor is known to play a crucial role in many physiological processes like hematopoiesis, immune regulation, pigmentation, gametogenesis, intestinal motility, vasculogenesis, lung and brain development. Likewise, aberrant c-kit stimulation results in several pathological conditions, including tumors of the gut, blood, lung, breast, germ cells, melanocytes and mast cells. Several pro-growth, prosurvival signaling pathways like the MAPK, PI-3K and the phospholipase C and D pathways are involved in mediating the downstream effects, following the activation of this receptor. The goal of this article is to provide a comprehensive review of the structure, function, signaling mechanisms of c-kit activation and its role in normal and pathological conditions.
Strategy Implementation: Does Hierarchy Culture Matter in Licensed Professional Societies in East Africa

Purpose: This study is aimed at establishing hierarchy and strategy relationship in registered professional bodies in Kenya. Design/Method/Approach: The dependent variable was measured through policy implementation, resource assessment and motivation. Hierarchy culture as an independent variable was measured through dominant characteristic and management of employees. Using a descriptive design approach, the study collected a return of 132 responses from a target of 168 in professional bodies of Kenya. The study set up a null hypothesis to be tested using a linear regression model to establish the relationship between dependent and independent variables. Findings: For hierarchy constructs, it was established that there was a significant correlation between strategy implementation and dominant characteristics r = . 316, p < . 05 with the management of employees r = . 288, p < . 05. Theoretical Implications: This paper expanded the body of research on organizational culture by showing that there is a significant relationship between the hierarchy culture and strategy implementation with both dominant characteristics and management of employees showing positive effects for the relationship. Originality/Value: This research shows that the organizations that are most successful in the market have a strong hierarchy culture within their environment. Therefore, professional bodies must at least have a mechanism of ensuring hierarchy culture within the organization. Research Limitations/Future Research: The study only looked at the association between hierarchy culture and strategy implementation. Future studies should investigate the relationship between strategy implementation and other dimensions of an organizational culture. Paper type: Empirical
Morphological and Molecular Identification of Ixodid Ticks that Infest Ruminants in Erbil province, Kurdistan Region-Iraq

A crosssectional survey was conducted in Erbil province from April to July 2021 to estimate the prevalence of major Ixodid ticks on ruminants and to identify tick species using morphological and molecular tools. A total of 687 animals (202 cattle, 287 sheep and 198 goats) examined, and 254 (36.9 %) were infested. About 381 ticks were collected from examined animals. The result identified two genera of six species of the hard ticks based on morphological, molecular investigation. The identified adult ticks morphologically were belonging to the two Ixodid genera, among which three species belonged to the genus Hyalomma (Hyalomma marginatum, Hyalomma anatolicum and H. exacavatum), and three species belonged to the genus Rhipocephalus (Rhipocephalus sanguineu, Rhipocephalus turanicus, and Rhipocephalus B. annulatus). R. annulatus was the dominant tick species infesting cattle with 50% which was significantly higher at P>0.05 than the other isolated species. Whereas H. excavatum and R. sanguineus was the prodominant tick species infesting sheep with 29.1% and 28.3 %respectively. While the infestation rate on goats was 16.7%, R. sanguineus was the most prevailed species infesting goats with 45.4% at (P>0.05). R. sanguineus were the predominant tick reported in Erbil governorate with 29.1% at (P>0.05). , while H. excavatum was reported in low percentage in Erbil at 10.2%. DNA samples from sixty ticks were chosen for molecular studies in order to detect tick species using a conventional PCR targeting the 16S rRNA gene. All sequences were subjected to a Basic Local Alignment Search Tool (BLAST) to determine their identities and assess their homologues and similarities to those in the Gen Bank. PCR and the sequencing have confirmed the morphological-based identification, Phylogenetic study revealed that the three Rhipicephalus genotypes revealed from the current study with accession number (MZ663757-MZ663759) were have a highly identical nucleotide sequence 99-100% with a strain of a Rhipicephalus turanicus, R. annulatus and R. sanguineus strain sequence (KY583068, MN594491 and MN594492) from China, and Iraq respectively. On the other hand phylogenetic analysis of Hyalomma genotypes from the present work with accession number (MZ663760-MZ663762) were closely related to a Hyalomma anatolicum, H. marginatum and Hyalomma exacavatum (MK829042, MG418663, and KP210047) from Egypt, Turkey and India respectively. © 2022 Production by the University of Garmian. This is an open access article under the LICENSE https://creativecommons.org/licenses/by-nc/4.0/
ENHANCING DETECTION PERFORMANCES OF NONHOMOGENEOUS WEIBULL CLUTTER BY KNOWLEDGE BASED SYSTEMS EXPLOITATION

|This article aims to study the behavior of Constant False Alarm Rate (CFAR) detectors for a heterogeneous Weibull clutter and its derivatives. CFAR architectures based on exploitation of the Combined Environmental Knowledge Base (CEKB) have been proposed, called Knowledge Based Systems-Maximum Likelihood-CFAR (KBS-ML-CFAR) and KBS-Log-t-CFAR for nonhomogeneous Weibull clutter at general parameters. A CFAR architecture that uses Geographic Information System (GIS) as a Knowledge Base (KB), called KBS-Forward Automatic Order Selection Ordered Statistics-CFAR (KBS-FAOSOS-CFAR) has been proposed for special Weibull parameters. The performances of the proposed detectors have been studied and analyzed by conducting MATLAB simulations. The simulation results show that the KBS-CFAR based on CEKB outperforms the ML and Log-t-CFAR in terms of clutter edge detection capability in nonhomogeneous Weibull clutter case. Compared with other KB, this KBS-CFAR based on CEKB performs well to preserve the probability of false alarm ( P fa ) at a desired constant value. For special Weibull parameters, the proposed KBS-FAOSOS-CFAR based on GIS performs better than KBS-Dynamic-CFAR and KBS-Adaptive Linear Combined-CFAR (KBS-ALC-CFAR) in severe interference case. CFAR techniques have been implemented on the ADSP (Advanced Digital Signal Processor) processing board, and the results have been evaluated and discussed.
Colorimetric quantification of linking in thermoreversible nanocrystal gel assemblies

Nanocrystal gels can be responsive, tunable materials, but designing their structure and properties is challenging. By using reversibly bonded molecular linkers, gelation can be realized under conditions predicted by thermodynamics. However, simulations have offered the only microscopic insights, with no experimental means to monitor linking leading to gelation. We introduce a metal coordination linkage with a distinct optical signature allowing us to quantify linking in situ and establish structural and thermodynamic bases for assembly. Because of coupling between linked indium tin oxide nanocrystals, their infrared absorption shifts abruptly at a chemically tunable gelation temperature. We quantify bonding spectroscopically and use molecular simulation to understand temperature-dependent bonding motifs, revealing that gel formation is governed by reaching a critical number of effective links that extend the nanocrystal network. Microscopic insights from our colorimetric linking chemistry enable switchable gels based on thermodynamic principles, opening the door to rational design of programmable nanocrystal networks.
Oridonin Alters Hepatic Urea Cycle via Gut Microbiota and Protects against Acetaminophen-Induced Liver Injury

Acetaminophen (APAP) hepatotoxicity is the leading cause of acute liver failure in the western world. Oridonin (OD), which is the major active ingredient of the traditional Chinese medicine Rabdosia rubescens, reportedly exerts anti-inflammatory and antioxidative effects. Here, we first find that OD protects against APAP-induced hepatotoxicity. The results of hepatic tissue-associated RNA-seq and metabolomics showed that the protective effects of OD were dependent upon urea cycle regulation. And such regulation of OD is gut microbiota partly dependent, as demonstrated by fecal microbiota transplantation (FMT). Furthermore, using 16S rRNA sequencing, we determined that OD significantly enriched intestinal Bacteroides vulgatus, which activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway to regulate redox homeostasis against APAP by urea cycle. In conclusion, our study suggests that the Bacteroides vulgatus-urea cycle-Nrf2 axis may be a potential target for reducing APAP-induced liver injury, which is altered by OD.
OP-MOLB180230 376..392

Activation of Rho-associated protein kinase 1 (ROCK1) and myotonic dystrophy kinase-related CDC42-binding kinase alpha (MRCKa) by caspases during apoptosis in vertebrates represents a prototypical example of co-option of kinases by proteases. How caspases acquired the ability to control these proteins during evolution of vertebrates is still unknown. Here, we report a phylogenetic and molecular study on the acquisition of caspase-cleavage sites in the family of Rho-activated kinases (RaKs). We demonstrate that the acquisition of such sites has more frequently occurred in identifiable intrinsically disordered regions (IDRs) within or flanking the coiled-coil domain. Thanks to computational identification of IDRs in protein sequences of different organisms, we predicted and validated the independent evolution of two caspase-cleavage sites in ROCK of arthropods and the loss of one of the MRCKa caspase-cleavage sites in ray-finned fishes. In conclusion, we shed light on the propensity of RaKs to evolve novel proteolytic sites, causing kinase activation and uniform subcellular distribution.
Research on the Involvement of Computer Graphics Algorithms in Systems for the Creation of Public Sculpture

Currently, there is less research on how to improve the efficiency of the application of computer graphics technology in the creation of public sculpture. Therefore, this paper will focus on how computer graphics algorithms can enable systems for the creation of public sculpture with the intervention of computer graphics technology to create more accurate and completed works of public sculpture. It will explore and analyze how computer image algorithms can help creators apply computer image technology to finish complete and accurate public sculptures, and individual studies, computer imagery, and model analysis are also used. In systems for the creation of public sculpture, the point cloud data of the model is obtained through 3D laser scanning technology; then the algorithm of the point cloud model is integrated and the Statistical Outlier Removal algorithm of the point cloud model intervention is processed. By this way, the point cloud model of the work is optimized, and then a more completed and accurate public sculpture work can be produced by 3D sculpting or 3D printing. The research shows that, in the creation of public sculptures with the intervention of computer graphics technology, the computer graphics algorithm acquires the basis of the high-definition public sculpture data model. The computer graphics algorithm improves the accuracy and completeness of the creator using computer graphics technology; it is also the key to transform the accurate enlargement and transformation of the sculptural model into the actual sculptural work.
Contrast Sensitivity Measurement Tests and Methods

Contrast is a measure of the amount of lightness or darkness an object has in relationship to its background. Usually, it is described as Contrast Sensitivity (CS), which actually is the inverse of the contrast threshold. More often than not, stimulus set includes grating patterns of various sizes that are presented in a stationary manner or are dynamically presented by reversing the contrast at different rates. A variety of tests were developed, in order to asses and evaluate contrast sensitivity, in many different ways. A classical method, to check for contrast sensitivity, is the Pelli-Robson contrast sensitivity chart. The Bailey-Lovie contrast sensitivity chart is another letter chart that deals with differences in the number of letters read on the high and low contrast charts, with a main drawback, the necessity to follow the size of the letters. The Functional Acuity Contrast Test is designed to identify vision loss from a variety of disorders, many of which are not detected by high or low contrast Snellen Acuity tests. The MARS Letter Contrast Sensitivity Test shows good agreement with the Pelli-Robson test and possibly it may be the alternative to the Pelli-Robson chart, in clinical practice and research.
OPTH_A_320505 4269..4280

*These authors contributed equally to this work Purpose: To compare changes in central retinal arterial equivalent (CRAE), central retinal vein equivalent (CRVE), arteriovenous ratio (AVR), tortuosity and fractal dimension in primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG) and in a control group (CG) on fundus photographs. Further, to provide further evidence of vascular change in glaucoma patients using a novel method of tortuosity. Patients and Methods: The primary endpoint was the change in CRAE, CRVE, AVR, fractal dimension and tortuosity of the retinal vasculature from baseline, retrospectively analyzed from 2011 to 2017 at the University Eye Hospital Tuebingen. Fundus photos of POAG (N = 49), NTG (N = 38) and CG (N = 18) were computer evaluated and analyzed in the quantities mentioned above. Results: CRAE in NTG and POAG and CRVE in NTG significantly decreased (P = 0.02, P = 0.01; P = 0.03) whereas CRVE in POAG increased insignificantly (P = 0.72). In NTG, AVR decreased significantly (P = 0.05), but to a lesser extent than in POAG (P < 0.001). In CG, CRAE decreased insignificantly (P = 0.10), CRVE decreased significantly (P = 0.03) and AVR increased insignificantly (P = 0.77). In POAG tortuosity calculated using standard methods as well as our novel method, increased significantly (P = 0.015–0.04), whereas it did not occur in NTG (P = 0.18–0.57) and CG (P = 0.11–0.21). Fractal dimensions in POAG decreased significantly (P = 0.001–0.002), whereas in NTG and CG changes were insignificant (P = 0.33–0.92). Conclusion: Based on a retrospective analysis of fundus photographs, specific retinal vasculature features of the retinal vasculature display significant alterations associated with NTG and POAG. The assessment of tortuosity using our novel method was consistent with previously established methods for analyzing tortuosity.
MOLECULAR STUDY AND PHYLOGENY OF Babesia spp. IN NATIVE SHEEP FROM SULAIMANI GOVENORATE/ NORTHERN IRAQ

This study was conducted to investigate Babesia parasites infecting sheep in eight districts of Sulaimani governorate/north Iraq from April to October 2017. Forty flocks of small ruminants were selected to collect blood samples randomly from 450 sheep. The samples were examined for babesiosis by microscopic examination and PCR. Primers based on the 18S rRNA were used for Babesia diagnosis, followed by sequencing of the amplicons for confirmation of the PCR product identities. Seventy-four samples (16.44%) showed the presence of Babesia piroplasms microscopically, while 116 (25.78%) samples were positive using PCR. Results showed that B. ovis was reported in 15.78% (n = 71), and B. motasi in 10.0% (n = 45) of the samples. Also, BLAST analysis of the obtained partial sequences of the 18S rRNA gene from current study isolates revealed the existence of both B. ovis and B. motasi, with a high homology degree of nucleotide identity with other nucleotide sequences of Babesia spp. in GenBank database. Distribution of babesiosis, according to the sampling time, revealed that high-frequency rates occur during July and August. Based on the result data, babesiosis was mainly caused by B. ovis and B. motasi.
Genome-wide identification and expression analysis of auxin response factors in peanut (Arachis hypogaea L.)

Auxin response factors (ARFs) are transcription factors that regulate the expression of auxin response genes, and have important functions in plant growth and development. In this study, available genome data for peanut (Arachis hypogaea L.) were used to identify AhARF genes. In total, 61 AhARFs and 23 AtARFs were divided into six groups (I–VI). Molecular structural analysis revealed that the protein members of AhARF contain at least two domains, the B3 domain and the Auxin-resp domain, and that some have a C-terminal dimerisation domain. Screening of the transcriptome data of 22 tissues of A. hypogaea cv. Tifrunner in a public database showed high expression levels of AhARF2 and AhARF6. AhARF6 was expressed more highly in the stem and branch than in the root and leaf of the wild species Arachis monticola (A. mon) and cultivated species H103. After treatment with exogenous auxin (NAA), the expression of AhARF6 was inhibited, and this inhibition was greater in A. mon than in H103. The transcriptome map revealed that the expression of AhARF6 was higher in the larger pods of H8107 and ZP06 than in the medium pods of H103 and small pods of A. mon. Moreover, AhARF6-5 was proven to be localised in the nucleus, consistent with the location of AtARF6. These results suggest that AhARF6 may play an important role in pod development in peanut.