Miracle-dz/UniFAR-FTUs huggingface dataset:
Schizophrenia and Hyperostosis Frontalis Interna with History of Head Injury

Hyperostosis frontalis interna is an irregular thickening of the frontal bone. Its etiology is unknown. It has been rarely linked with schizophrenia and head injury. Case Presentation. We describe an unusual case of a 44-year-old female with schizophrenia and hyperostosis frontalis interna having a history of head trauma. At the age of 3 years, she had a head injury that could be classified as mild traumatic brain injury. She presents a family history of schizophrenia. She was admitted for resistant schizophrenic disorder. The cranial computed tomography showed bilateral and asymmetrical hyperostosis of the frontal bone that was more pronounced on the right side. This corresponds to the impact of the trauma with frontal atrophy without any metabolic or endocrinal abnormalities. Conclusion. We surmise that the long-term pathological effects of traumatic brain injury, including hyperostosis frontalis interna, are likely to interact with genetic vulnerability and may lead to schizophrenic disorder.
Effects of government policies and the Nowruz holidays on confirmed COVID-19 cases in Iran: An intervention time series analysis

Background Public health policies with varying degrees of restriction have been imposed around the world to prevent the spread of coronavirus disease 2019 (COVID-19). In this study, we aimed to evaluate the effects of the implementation of government policies and the Nowruz holidays on the containment of the COVID-19 pandemic in Iran, using an intervention time series analysis. Methods Daily data on COVID-19 cases registered between February 19 and May 2, 2020 were collected from the World Health Organization (WHO)’s website. Using an intervention time series modeling, the effect of two government policies on the number of confirmed cases were evaluated, namely the closing of schools and universities, and the implementation of social distancing measures. Furthermore, the effect of the Nowruz holidays as a non-intervention factor for the spread of COVID-19 was also analyzed. Results The results showed that, after the implementation of the first intervention, i.e., the closing of universities and schools, no statistically significant change was found in the number of new confirmed cases. The Nowruz holidays was followed by a significant increase in new cases (1,872.20; 95% CI, 1,257.60 to 2,476.79; p<0.001)), while the implementation of social distancing measures was followed by a significant decrease in such cases (2,182.80; 95% CI, 1,556.56 to 2,809.04; p<0.001). Conclusion The Nowruz holidays and the implementation of social distancing measures in Iran were related to a significant increase and decrease in COVID-19 cases, respectively. These results highlight the necessity of measuring the effect of health and social interventions for their future implementations.
Hybrid Collaborative-Context Based Recommendations for Civil Affairs Operations

 Abstract — In this paper we present findings from a research effort to apply a hybrid collaborative-context approach for a system focused on Marine Corps civil affairs data collection, aggregation, and analysis called the Marine Civil Information Management System (MARCIMS). The goal of this effort is to provide operators with information to make sense of the interconnectedness of entities and relationships in their area of operation and discover existing data to support civil military operations. Our approach to build a recommendation engine was designed to overcome several technical challenges, including 1) ensuring models were robust to the relatively small amount of data collected by the Marine Corps civil affairs community; 2) finding methods to recommend novel data for which there are no interactions captured; and 3) overcoming confirmation bias by ensuring content was recommended that was relevant for the mission despite being obscure or less well known. We solve this by implementing a combination of collective matrix factorization (CMF) and graph-based random walks to provide recommendations to civil military operations users. We also present a method to resolve the challenge of computation complexity inherent from highly connected nodes through a precomputed process.
Navigating Intersectional Stigma: Strategies for Coping Among Cisgender Women of Color

Intersectionality is a critical tool for understanding how socially constructed categories shape multiple dimensions of lived experience. In this study, we apply an intersectional lens to explore how women of color from two different contexts, Hyderabad, India and Chicago, Illinois, manage gendered forms of stigma and oppression as they converge with other devalued statuses, namely living with HIV or having a history of drug use or incarceration. Applying intersectional stigma as our conceptual framework, and drawing from transnational feminist perspectives, we identified two overarching themes. Women in both contexts combat stigma by employing strategies of concealment within their romantic and familial systems. Moreover, women’s roles as mothers were critical sources for managing their complex illnesses and for accessing support. Using these experiences of stigma against women of color as our analytic lens, we offer an intersectional framework for qualitative health research involving marginalized cisgender women of color in transnational contexts.
Fluctuating selection driven by global and local climatic conditions leads to stasis in breeding time in a migratory bird

The origin of natural selection is linked to environmental heterogeneity, which influences variation in relative fitness among phenotypes. However, individuals in wild populations are exposed to a plethora of biotic and abiotic environmental factors. Surprisingly, the relative influence of multiple environmental conditions on the relative fitness of phenotypes has rarely been tested in wild populations. Identifying the main selection agent(s) is crucial when the target phenotype is tightly linked to reproduction and when temporal variation in selection is expected to affect evolutionary responses. By using individual‐based data from a 29‐year study of a short‐lived migratory songbird, the pied flycatcher (Ficedula hypoleuca), we studied the relative influence of 28 temperature‐ and precipitation‐based factors at local and global scales on selection on breeding time (egg laying) at the phenotypic level. Selection, estimated using the number of recruits as a proxy for fitness, penalized late breeders. Minimum temperatures in April and May were the environmental drivers that best explained selection on laying date. In particular, there was negative directional selection on laying date mediated by minimum temperature in April, being strongest in cold years. In addition, nonlinear selection on laying date was influenced by minimum temperatures in May, with selection on laying date changing from null to negative as the breeding season progressed. The intensity of selection on late breeders increased when minimum temperatures in May were highest. Our results illustrate the complex influence of environmental factors on selection on laying date in wild bird populations. Despite minimum temperature in April being the only variable that changed over time, its increase did not induce a shift in laying date in the population. In this songbird population, stabilizing selection has led to a three‐decade stasis in breeding time. We suggest that variation in the effects of multiple climatic variables on selection may constrain phenotypic change.
Lower platelet counts were associated with 90-day adverse outcomes in acute-on-chronic liver disease patients.

BACKGROUND Chronic liver diseases (CLD), including cirrhosis and non-cirrhotic liver diseases, are globally widespread and create a serious disease burden. Platelet count is a clinically accessible and affordable prognostic indicator of liver disease. We investigated the relationship between platelet count and 90-day prognosis in patients with acute-on-chronic liver diseases (AoCLD). METHODS A total of 3,970 patients with AoCLD from the Chinese Acute-on-Chronic Liver Failure (CATCH-LIFE) study, which included two prospective multi-center cohorts, were included in the study. We grouped the patients according to the platelet count and analyzed the 90-day adverse outcome (death or liver transplantation). RESULTS In the final analysis, 3,939 patients with AoCLD were included, of whom 2,802 had definite liver cirrhosis. The cumulative incidence of 90-day adverse outcomes in patients increased with the change of platelet group (log-rank P<0.001). From univariate and multivariate analyses, platelet count was inversely associated with the incidence of 90-day adverse outcomes in patients (P for trend <0.001). The group with platelet count <20×109 /L had the highest risk (odds ratio, 3.15; 95% confidence interval, 1.59-6.25), with 21 (36.8%) of these patients having adverse outcomes within 90 days. The risk of a 90-day adverse outcome in patients increased by 5% for every 10×109 /L decrease in platelet count below 210×109 /L. CONCLUSIONS Lower platelet count was associated with a higher incidence of 90-day adverse outcomes in patients with AoCLD. Even within the normal platelet count range, the risk of a 90-day adverse outcome in patients increased with decreases in platelet count. Clinical trial number: NCT02457637, NCT03641872.
Highly sensitive and wearable NO2 gas sensor based on PVDF nanofabric containing embedded polyaniline/g-C3N4 nanosheet composites

In this study, a highly flexible and wearable nitrogen dioxide (NO2) gas sensor was fabricated based on electrospun poly(vinylidene fluoride) (PVDF)/polyaniline (PANi)/graphitic-carbon nitride (g-C3N4) blend nanocomposite (EBNC). g-C3N4/PANi nanocomposite (GPC) was synthesized by in situ polymerization technique prior to its incorporation into PVDF nanofibers, which ensured uniformity of dispersion. For the comparison study, PVDF/GPC nanocomposite film was fabricated using doctor blade technique. EBNC sensor exhibited high sensitivity, selectivity, reproducibility along with quick response and complete recovery. Electrospinning and GPC synergistically improved the performance of the EBNC based gas sensor. The superior gas sensing ability along with its low cost and the use of scalable electrospinning technique could make this system a promising one for the detection of gaseous NO2.
Ten simple rules for Global North researchers to stop perpetuating helicopter research in the Global South

The practice of Global North (i.e., “richer” globalized countries located in the northern hemisphere, except for Australia and New Zealand) researchers making roundtrips to the Global South (i.e., “poorer” developing countries located around the tropics and in the Southern hemisphere) to collect materials and then process, analyze, and publish results with little to no involvement from local collaborators is referred to as “helicopter research” or “parachute research” [1]. At best, local scientists provide logistical help and knowledge of the local community, such as field site guiding, identification of local organisms, translation from and to local languages, and facilitating resources to foreign scientists. However, often, these necessary actors in the scientific process receive little to no retribution for their work and knowledge. For example, a systematic problem in academia is that local scientists and graduate and undergraduate students are often not offered coauthorship in manuscripts for which their contributions were essential (e.g., project planning, logistics, and knowledge of local biodiversity). Even worse is that research remains unavailable for them and others who contributed substantially, since in most cases, peer-review publications are available behind a paywall (but see [2]), and they are written in English, which is the second or third language for many Global South researchers [3]. Furthermore, local communities where Global North scientists come to conduct helicopter research are usually left out of broader impacts and outreach efforts, as these tend to happen in Global North communities. Helicopter research is a way to perpetuate colonization practices [4], and power imbalances are critical in perpetuating helicopter research. For example, Global North researchers often set the research agenda based on priorities of their funding agencies, which, in many cases, are decided upon by those same researchers sitting in decision-making committees of those very agencies. All too often, proposals are developed without a deep understanding of problems and priorities of Global South countries where the anticipated research will take place. Global South collaborators are rarely invited to brainstorm and set the research agenda for their needs. This opens the door for unequal partnership with research objectives that may be irrelevant for Global South collaborators, who then, are forced to accept an already funded proposal due to lack of research funding within their own countries or institutions [5]. Thus, power and politics behind science are interconnected and are a driving force behind helicopter research. Helicopter research is a problem that also happens within Global North and within Global South countries, where dominating cultures perpetuate abuse on historically marginalized communities, including those of indigenous people, people of color, people from lower
Chemogenetics: drug-controlled gene therapies for neural circuit disorders

Many patients with nervous system disorders have considerable unmet clinical needs or suffer debilitating drug side effects. A major limitation of exiting treatment approaches is that traditional small molecule pharmacotherapy lacks sufficient specificity to effectively treat many neurological diseases. Chemogenetics is a new gene therapy technology that targets an engineered receptor to cell types involved in nervous system dysfunction, enabling highly selective drug-controlled neuromodulation. Here, we discuss chemogenetic platforms and considerations for their potential application as human nervous system therapies.
RNA‐binding protein Hfq downregulates locus of enterocyte effacement‐encoded regulators independent of small regulatory RNA in enterohemorrhagic Escherichia coli

Enterohemorrhagic Escherichia coli (EHEC) causes severe human diseases worldwide. The type 3 secretion system and effector proteins are essential for EHEC infection, and are encoded by the locus of enterocyte effacement (LEE). RNA‐binding protein Hfq is essential for small regulatory RNA (sRNA)‐mediated regulation at a posttranscriptional level and full virulence of many pathogenic bacteria. Although two early studies indicated that Hfq represses LEE expression by posttranscriptionally controlling the expression of genes grlRA and/or ler, both of which encode LEE regulators mediating a positive regulatory loop, the detailed molecular mechanism and biological significance remain unclear. Herein, we show that LEE overexpression was caused by defective RNA‐binding activity of the Hfq distal face, which posttranscriptionally represses grlA and ler expression. In vitro analyses revealed that the Hfq distal face directly binds near the translational initiation site of grlA and ler mRNAs, and inhibits their translation. Taken together, we conclude that Hfq inhibits grlA and ler translation by binding their mRNAs through the distal face in an sRNA‐independent manner. Additionally, we show that Hfq‐mediated repression of LEE is critical for normal EHEC growth because all suppressor mutations that restored the growth defect in the hfq mutant abolished hfq deletion‐induced overexpression of LEE.
A line through the brain: implementation of human line-scanning at 7T for ultra-high spatiotemporal resolution fMRI

Functional magnetic resonance imaging (fMRI) is a widely used tool in neuroscience to detect neurally evoked responses, e.g. the blood oxygenation level-dependent (BOLD) signal. Typically, BOLD fMRI has millimeter spatial resolution and temporal resolution of one to few seconds. To study the sub-millimeter structures and activity of the cortical gray matter, the field needs an fMRI method with high spatial and temporal resolution. Line-scanning fMRI achieves very high spatial resolution and high sampling rate, at the cost of a sacrifice in volume coverage. Here, we present a human line-scanning implementation on a 7T MRI system. First, we investigate the quality of the saturation pulses that suppress MR signal outside the line. Second, we established the best coil combination for reconstruction. Finally, we applied the line-scanning method in the occipital lobe during a visual stimulation task, showing BOLD responses along cortical depth, every 250 µm with a 200 ms repetition time (TR). We found a good correspondence of t-statistics values with 2D gradient-echo echo planar imaging (GE-EPI) BOLD fMRI data with the same temporal resolution and voxel volume (R = 0.6 ± 0.2). In summary, we demonstrate the feasibility of line-scanning in humans and this opens line-scanning fMRI for applications in cognitive and clinical neuroscience.
Toxicity of Nanoparticles in Biomedical Application: Nanotoxicology

Nanoparticles are of great importance in development and research because of their application in industries and biomedicine. The development of nanoparticles requires proper knowledge of their fabrication, interaction, release, distribution, target, compatibility, and functions. This review presents a comprehensive update on nanoparticles' toxic effects, the factors underlying their toxicity, and the mechanisms by which toxicity is induced. Recent studies have found that nanoparticles may cause serious health effects when exposed to the body through ingestion, inhalation, and skin contact without caution. The extent to which toxicity is induced depends on some properties, including the nature and size of the nanoparticle, the surface area, shape, aspect ratio, surface coating, crystallinity, dissolution, and agglomeration. In all, the general mechanisms by which it causes toxicity lie on its capability to initiate the formation of reactive species, cytotoxicity, genotoxicity, and neurotoxicity, among others.
A bilingual word-length effect: Implications for intelligence testing and the relative ease of mental calculation in Welsh and English

Five experiments are reported. These demonstrate that, in bilingual subjects, Welsh digits take longer to articulate than their English equivalents, and this difference is paralleled by the finding that digit span in Welsh is significantly smaller than that in English. These differences are attributable to bilingual word-length differences, and it is this, rather than intellectual differences, which explains why the norms for Welsh children on the digit span test of the Welsh Children’s Intelligence Scale are reliably less than those for the same age American children tested on the similar digit span procedure of the Wechsler Intelligence Scale for Children. These findings lead to the prediction that mental calculation in the Welsh language will be more difficult than that in English.
A randomized control trial of a behavioral intervention for older adults with subjective cognitive complaints that combines cognitive rehabilitation strategies and lifestyle modifications

ABSTRACT This study examined the effectiveness of a 10-week cognitive rehabilitation and lifestyle modifying intervention that integrated compensation strategies, engagement in brain activities, and improving everyday function. The trial was registered with ClinicalTrials.gov (NCT03549078). Older adults with subjective cognitive concerns and normal performance on a cognitive screener were randomized into the intervention (n = 28) or waitlist control (n = 29) groups. The total sample comprised 57 individuals (age, mean = 74.8, SD = 6.5), mostly female (80.4% of the total sample), and well educated (education years: mean = 15.9, SD = 2.1). Outcome measures were completed at baseline, and immediately and 3- and 6-months post-intervention. Intervention participants reported significant improvements in aspects of everyday functioning and select compensation strategies and brain health activities. Increased compensation strategy use was maintained at 6-month follow up. This intervention has benefits for improving everyday functioning and increasing engagement with compensation strategies and brain health activities.
Small Brain Lesion Enhancement and Gadolinium Deposition in the Rat Brain

Objectives The aim of the set of studies was to compare gadopiclenol, a new high relaxivity gadolinium (Gd)–based contrast agent (GBCA) to gadobenate dimeglumine in terms of small brain lesion enhancement and Gd retention, including T1 enhancement in the cerebellum. Materials and Methods In a first study, T1 enhancement at 0.1 mmol/kg body weight (bw) of gadopiclenol or gadobenate dimeglumine was evaluated in a small brain lesions rat model at 2.35 T. The 2 GBCAs were injected in an alternated and cross-over manner separated by an interval of 4.4 ± 1.0 hours (minimum, 3.5 hours; maximum, 6.1 hours; n = 6). In a second study, the passage of the GBCAs into cerebrospinal fluid (CSF) was evaluated by measuring the fourth ventricle T1 enhancement in healthy rats at 4.7 T over 23 minutes after a single intravenous (IV) injection of 1.2 mmol/kg bw of gadopiclenol or gadobenate dimeglumine (n = 6/group). In a third study, Gd retention at 1 month was evaluated in healthy rats who had received 20 IV injections of 1 of the 2 GBCAs (0.6 mmol/kg bw) or a similar volume of saline (n = 10/group) over 5 weeks. T1 enhancement of the deep cerebellar nuclei (DCN) was assessed by T1-weighted magnetic resonance imaging at 2.35 T, performed before the injection and thereafter once a week up to 1 month after the last injection. Elemental Gd levels in central nervous system structures, in muscle and in plasma were determined by inductively coupled plasma mass spectrometry (ICP-MS) 1 month after the last injection. Results The first study in a small brain lesion rat model showed a ≈2-fold higher number of enhanced voxels in lesions with gadopiclenol compared with gadobenate dimeglumine. T1 enhancement of the fourth ventricle was observed in the first minutes after a single IV injection of gadopiclenol or gadobenate dimeglumine (study 2), resulting, in the case of gadopiclenol, in transient enhancement during the injection period of the repeated administrations study (study 3). In terms of Gd retention, T1 enhancement of the DCN was noted in the gadobenate dimeglumine group during the month after the injection period. No such enhancement of the DCN was observed in the gadopiclenol group. Gadolinium concentrations 1 month after the injection period in the gadopiclenol group were slightly increased in plasma and lower by a factor of 2 to 3 in the CNS structures and muscles, compared with gadobenate dimeglumine. Conclusions In the small brain lesion rat model, gadopiclenol provides significantly higher enhancement of brain lesions compared with gadobentate dimeglumine at the same dose. After repeated IV injections, as expected for a macrocyclic GBCA, Gd retention is minimalized in the case of gadopiclenol compared with gadobenate dimeglumine, resulting in no T1 hypersignal in the DCN.