Miracle-dz/UniFAR-FTUs huggingface dataset:
Elastodynamic analyses of transversely isotropic unsaturated subgrade–pavement system under moving loads

In this paper, elastodynamic responses of the layered transversely isotropic unsaturated subgrade–pavement system subjected to the moving load are investigated. The unsaturated subgrade soil is described via a triphasic Biot‐type model introducing the effect of matric suction, immiscible flows of water and air, and transverse isotropy. The rigid pavement is modeled by the Kirchhoff plate theory, while the flexible pavement is modeled by the stratification medium theory. First, the governing equations of the unsaturated subgrade soil are obtained after algebraical manipulations. The precise integration method (PIM) is further combined with the double Fourier transform to solve the governing equations. The subgrade soil solution is utilized as the flexible coefficient to describe the plate–soil interaction, and the solution of the pavement is further acquired via the double inverse Fourier transform. Four verification examples regarding literatures and COMSOL are presented to verify the correctness of the theory. Finally, numerical examples are conducted to investigate the effect of various parameters on the dynamic behavior of the unsaturated subgrade–pavement system.
Comprimentos de seção e altura de fustes na cubagem rigorosa em diferentes espaçamentos de eucalipto

Objetivou-se avaliar a influência do comprimento de seções e alturas totais para a quantificação volumétrica de fustes de eucalipto em diferentes espaçamentos de plantio. Os volumes dos fustes com casca foram calculados utilizando-se a fórmula de Smalian, considerando seções de 1, 2, . , 6 m de comprimento após a posição de 2 m de altura. As posições de cubagem da base foram padronizadas. Realizou-se a modelagem para a estimativa dos erros percentuais em função do comprimento de seção e altura de fustes. As estimativas de erro foram maiores em seções mais longas e fustes de menor altura total. Conclui-se que seções mais longas levam a superestimativas do volume acima da posição de 2 m de altura e, consequentemente, do volume total do fuste. Seções de comprimento superior a 2 m devem ser evitadas em cubagens rigorosas, sobretudo, quando realizadas em talhões instalados sob espaçamentos de 1,5 a 6 m2.
Two-dimensional polymers made of carbonyl-bridged heterotriangulenes are promising anode materials for Li-ion batteries

By means of first-principles calculations, we have explored the potential of two-dimensional (2D) polymers made of carbonyl-bridged triphenylamine (CTPA) and carbonyl-bridged triphenylborane (CTPB) as electrode materials for lithium-ion batteries (LIBs). Our investigations demonstrate that the carbonyl groups of 2D CTPB and CTPA are rather active to accommodate Li. Both 2D CTPA and CTPB show the transition from semiconductor to metal after combining with Li. The migration of Li through the pore space of 2D CTPB and CTPA is facilitated with a small diffusion barrier of 0.76 and 0.79 eV, respectively. 2D CTPB exhibits a high theoretical capacity of 760.86 mAh g−1 because it can accommodate Li at both the carbonyl sites and the surface sites of the skeleton, which is ascribed to the promotion of the electron-deficient B center. As a comparison, 2D CTPA can only combine with Li at the carbonyl sites and shows a capacity of 251.09 mAh g−1. With fast Li-diffusion ability, high capacity and low average operating voltage, 2D CTPA and CTPB are predicted to be promising non-metal anode materials for LIBs.
Age-and sex-related changes in selected hematological parameters, lipid peroxidation and erythrocytes osmotic fragility of Turkish Angora cats

This study was conducted to investigate the changes in selected hematological parameters, lipid peroxidation and osmotic fragility of erythrocytes in Angora cats depending on the age and gender. For this purpose, the blood samples were collected from 9 young and 14 adult cats which also classified as male (n=12) and female (n=11). Following hematological analysis, samples were washed with PBS by centrifugation and 10% hematocrit suspension was prepared from the erythrocytes pellet for osmotic fragility test. The concentration of malondialdehyde (MDA) was also measured from lysed erythrocyte to determine lipid peroxidation level. Red blood cells (RBCs), hemoglobin, and hematocrit were high in adults while mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration were high in young cats. Erythrocyte MDA level was also higher in adult cats than in young cats. There was no significance in these parameters between male and female cats. Findings of fragility tests were showed that erythrocytes of young and male cats were more susceptible to hypotonic NaCl solutions than those of adult and female cats, respectively. It was concluded that erythrocytes related parameters in Angora cats changed depending on the age rather than gender except stability of RBCs.
Mutations in KMT2C, BCOR and KDM5C Predict Response to Immune Checkpoint Blockade Therapy in Non-Small Cell Lung Cancer

Simple Summary Efficient biomarkers are urgently needed to predict response to immune checkpoint blockade (ICB) therapy for non-small cell lung cancer (NSCLC), particularly NSCLC with low tumor mutational burden (TMB). Here, we show that mutations of three chromatin remodeling-related genes, including KMT2C, BCOR and KDM5C, are associated with the ICB response in NSCLC, including NSCLC with low TMB level. Furthermore, this association is further improved by a combined use of KMT2C/BCOR/KDM5C mutations with TMB or PD-L1 expression. These data suggest that KMT2C/BCOR/KDM5C mutation status has the potential to serve as a predictive biomarker for ICB therapy in NSCLC. Abstract Efficient predictive biomarkers are urgently needed to identify non-small cell lung cancer (NSCLC) patients who could benefit from immune checkpoint blockade (ICB) therapy. Since chromatin remodeling is required for DNA repair process, we asked whether mutations in chromatin remodeling genes could increase tumor mutational burden (TMB) and predict response to ICB therapy in NSCLC. Analysis of seven ICB-treated NSCLC cohorts revealed that mutations of three chromatin remodeling-related genes, including KMT2C, BCOR and KDM5C, were significantly associated with ICB response, and combined mutations of these three genes further enhance this association. NSCLC patients with KMT2C/BCOR/KDM5C mutations had comparable clinical outcomes to TMB-high patients in terms of objective response rate, durable clinical benefit and overall survival. Although KMT2C/BCOR/KDM5C mutations were positively correlated with TMB levels in NSCLC, the association of this mutation with better ICB response was independent of tumor TMB and programmed death-ligand 1 (PD-L1) level, and combination of KMT2C/BCOR/KDM5C mutations with TMB or PD-L1 further improve the prediction of ICB response in NSCLC patients. Cancer Genome Atlas (TCGA) pan-cancer analysis suggested that the association of KMT2C/BCOR/KDM5C mutations with ICB response observed here might not result from DNA repair defects. In conclusion, our data indicate that KMT2C/BCOR/KDM5C mutation has the potential to serve as a predictive biomarker, alone or combined with PD-L1 expression or TMB, for ICB therapy in NSCLC.
Shape Deformation, Budding and Division of Giant Vesicles and Artificial Cells: A Review

The understanding of the shape-change dynamics leading to the budding and division of artificial cells has gained much attention in the past few decades due to an increased interest in designing stimuli-responsive synthetic systems and minimal models of biological self-reproduction. In this respect, membranes and their composition play a fundamental role in many aspects related to the stability of the vesicles: permeability, elasticity, rigidity, tunability and response to external changes. In this review, we summarise recent experimental and theoretical work dealing with shape deformation and division of (giant) vesicles made of phospholipids and/or fatty acids membranes. Following a classic approach, we divide the strategies used to destabilise the membranes into two different types, physical (osmotic stress, temperature and light) and chemical (addition of amphiphiles, the addition of reactive molecules and pH changes) even though they often act in synergy when leading to a complete division process. Finally, we review the most important theoretical methods employed to describe the equilibrium shapes of giant vesicles and how they provide ways to explain and control the morphological changes leading from one equilibrium structure to another.
Validity and Reliability Test of Child Anxiety Instrument (SCARED) on Students of Sekolah Dasar Kedungsari 5 Magelang

Anxiety disorders rank the 9th cause of DALYs, which can have long-term effects. The COVID-19 pandemic can trigger anxiety disorders in children related to changes in learning, habituation of new behaviors, COVID-19 disease itself, and other factors. Detection of anxiety disorders in children needs to be done early so that it can avoid its long-term effects. Screen for Children Anxiety Related Emotion Disorder (SCARED) is a multi-informant instrument that is considered good for screening anxiety disorders in children, so it is necessary to assess its validity and reliability so that it can be used in Indonesia. This study aimed to test the validity and reliability SCARED instrument in Indonesian to measure the tendency of children's Anxiety Disorders. This study was an observational study with a cross-sectional design. Subjects were students of Sekolah Dasar Negeri Kedungsari 5 Magelang (n=220). Content validity test using Pearson product-moment and construct validity test using CFA. Concurrent test with RCMAS using Pearson correlation. Reliability test by calculating the value of Cronbach alpha. The result content validity test showed that all children's versions of SCARED items and parents' versions of SCARED had r counts above r tables. There was concern with the RCMAS and the SCARED children version concurrent with the parent version. Cronbach's alpha value of SCARED child version 0.901 and parent version 0.891. The Indonesian version of SCARED is a valid and reliable instrument to assess the tendency of children's anxiety disorders in elementary school students.
T RELLIS : V ISUAL T OPIC A GGREGATION

With increasing availability of large volumes of text data, researchers from many ﬁelds have more documents than they can easily analyze by hand. Topic models are powerful computational tools that can be of great beneﬁt to these researchers, but technical requirements can make these models inaccessible to a broad audience. With the goal of empowering users to examine their text data and reﬁne models of their corpora based on domain expertise, Trellis is a visual tool for topic model curation and dataset exploration. By allowing researchers to visually interact with their datasets and aggregate topics within the model, Trellis enables an iterative process of adjusting a working hierarchical topic model and examining the corresponding dataset based on that working model.
Assessing the Role of Information and Communication Technology on Business Growth in Sumatera Island, Indonesia

Teknologi informasi dan komunikasi (TIK) telah menjadi bagian tak terpisahkan dari kehidupan sehari-hari, termasuk dalam bisnis. TIK adalah teknologi yang digunakan untuk menganalisis, menyimpan, dan menyebarkan informasi, serta mendorong operasi yang saling terkait dan efisien guna mendukung kinerja bisnis yang lebih baik. Penelitian ini bertujuan untuk menguji perbedaan pertumbuhan bisnis antara perusahaan yang menggunakan dan tidak menggunakan teknologi informasi dan komunikasi (TIK). Penelitian dilakukan di Pulau Sumatera, Indonesia. Sumatera dipilih karena meskipun merupakan penyumbang ekonomi terbesar kedua bagi Indonesia setelah Jawa, namun indeks perkembangan TIK-nya rendah dibandingkan dengan wilayah lain. Studi ini memanfaatkan gelombang data publik terbaru dari Survei Perusahaan Bank Dunia untuk Indonesia. Enterprise Survey mensurvei 194 perusahaan di dua provinsi: Provinsi Sumatera Utara dan Provinsi Lampung. Chi-square dan Mann-Whitney U Test digunakan untuk menganalisis data. Berdasarkan hasil temuan, TIK lebih umum digunakan di perusahaan besar, sementara lebih jarang digunakan di UKM. Pertumbuhan bisnis perusahaan yang menggunakan dan tidak menggunakan media email berbeda secara signifikan, sedangkan perbedaan dalam pemanfaatan situs web tidak signifikan. Perbedaan kecil dalam penggunaan situs web dapat dikaitkan dengan semakin populernya perantara dalam platform e-niaga yang inovatif.
pruR and PA0065 Genes Are Responsible for Decreasing Antibiotic Tolerance by Autoinducer Analog-1 (AIA-1) in Pseudomonas aeruginosa

Pseudomonas aeruginosa infection is considered a high-risk nosocomial infection and is very difficult to eradicate because of its tolerance to antibiotic treatment. A new compound, autoinducer analog-1 (AIA-1), has been demonstrated to reduce antibiotic tolerance, but its mechanisms remain unknown. This study aimed to investigate the mechanisms of AIA-1 in the antibiotic tolerance of P. aeruginosa. A transposon mutant library was constructed using miniTn5pro, and screening was performed to isolate high tolerant mutants upon exposure to biapenem and AIA-1. We constructed a deletion mutant and complementation strain of the genes detected in transposon insertion site determination, pruR and PA0066-65-64, and performed killing assays with antibiotics and AIA-1. Gene expression upon exposure to biapenem and AIA-1 and their relationship to stress response genes were analyzed. High antibiotic tolerance was observed in Tn5-pruR and Tn5-PA0065 transposon mutants and their deletion mutants, ΔpruR and ΔPA0066-65-64. Complemented strains of pruR and PA0066-65-64 with their respective deletion mutants exhibited suppressed antibiotic tolerance. It was determined that deletion of PA0066-65-64 increased rpoS expression, and PA0066-65-64 affects antibiotic tolerance via the rpoS pathway. Additionally, antibiotics and AIA-1 were found to inhibit pruR and PA0066-65-64. This study proposed that pruR and PA0066-65-64 are members of the antibiotic tolerance suppressors.
Barriers to adult vaccination in Canada: A qualitative systematic review

Background: In recent years, Canadian health care professionals have observed an increase in vaccine refusal. The objective of this study is to review published literature and identify the main themes related to vaccine hesitancy and barriers to vaccination in Canadian adults and recent immigrants. Methods: A qualitative systematic review was performed. A comprehensive search of MEDLINE (1946 to January 2021) and EMBASE (1974 to January 2021) was conducted to identify existing literature that addressed the primary research question. Studies were eligible for inclusion if the study population involved 1) the general population, 2) Indigenous populations, 3) recent immigrants to Canada or 4) Canadian health care professionals. Results: Thirty-four studies were included with a focus on the general population (n = 22), health care professionals (n = 10) and recent immigrant populations (n = 2). The most frequently reported barriers were lack of vaccine information (41%), lack of access to vaccination (38%), fear of adverse reactions (38%), financial reasons (29%), lack of awareness of vaccine existence (29%), antivaccine sentiments (24%), notion that older adults do not need vaccination (18%), misconceptions on vaccine effectiveness (12%), potential sexual health promotion stigma (6%) and fear of needles (3%). Interpretation: Barriers to vaccination among Canadians and recent immigrants continue to be a challenge in the health care system. Conclusions: The greatest yield in improving vaccination rates is likely to come from supporting vaccine-hesitant individuals in shifting their thinking to greater vaccine acceptance. Pharmacists are well positioned to address vaccine hesitancy and involvement through education, facilitation and administration of vaccines. Can Pharm J (Ott) 2022;155:xx-xx.
Development of Digital Biomarkers of Mental Illness via Mobile Apps for Personalized Treatment and Diagnosis

The development of precision psychiatry is largely based on multi-module measurements from the molecular, cellular, and behavioral levels, which are integrated to assess neurocognitive performances and clinically observed psychopathology. Nevertheless, quantifying mental activities and functions accurately and continuously has been a major difficulty within this field. This article reviews the latest efforts that utilize mobile apps to collect human–smartphone interaction data and contribute towards digital biomarkers of mental illnesses. The fundamental principles underlying a behavioral analysis with mobile apps were introduced, such as ways to monitor smartphone use under different circumstances and construct long-term patterns and trend changes. Examples were also provided to illustrate the potential applications of mobile apps that gain further insights into traditional research topics in occupational health and sleep medicine. We suggest that, with an optimized study design and analytical approach that accounts for technical challenges and ethical considerations, mobile apps will enhance the systemic understanding of mental illnesses.
A Review on Malware Detection Methods

With the expeditious improvement of the internet and information technology, malicious codes and attacks pose a critical threat to internet and computer security. These attacks and malicious codes are increased exponentially and caused huge amounts of financial damage. The potential to recognize several malicious code variants and threats is crucial for preservation across unauthorized access to computer data, information, data theft, security breaches, etc. Recent methods for identifying malicious codes and threats have indicated less precision and deficient speeds. This paper aims to conduct a brief and systematic survey on the malware detection methods based on the soft computing model. This work is expected to help researchers to understand the malware detection technology and the direction of its research development.
The lived experiences of elderly women accused of witchcraft in a rural community in South Africa

This study examines the experiences, fear of being killed, and reactions towards accusations of elderly women, accused of witchcraft. The respondents were elderly women with an average age of 65 years who had retired in rural South Africa. They responded to semi-structured interview questions, aimed at documenting the accusations and insults, hurled at them daily by members of community. Thematic analysis indicated the community’s hostile reaction towards the women. The following themes and corresponding sub-themes were established: demographics, cultural factors, with sub-themes of old age and circumstances, surrounding death; and socio-economic factors, with sub-themes of poverty, unemployment, and jealousy. Based on their personal experiences, the community did not have concrete evidence of their accusations, which stemmed from external factors, over which they had no control. These findings were explained as being the authorities not protecting victims against all accusations. These accusations of witchcraft happened despite the protection of the constitution, the bill of rights and relevant legislation. In conclusion the law enforcement agencies must enforce the law to protect the elderly women in the communities.
Evidence of alternative trophic pathways for fish consumers in a large river system in the face of invasion

Large rivers are susceptible to anthropogenic alteration, which can result in drastic changes to their functional ecology. We evaluated spatial–temporal changes in the functional fish communities of the Upper Mississippi River System (UMRS) using data from six study reaches. Species were classified into one of 14 feeding guilds and mass per unit effort (MPUE) was then calculated for each feeding guild annually per gear type. MPUE was standardized using the multigear mean standardization method (MGMS) and log‐transformed. Both ANOSIM and Chi‐square tests were used to determine differences in MPUE among reaches. We then estimated functional diversity by calculating the number of functional groups (N), Margalef's d, Pielou's J′, Shannon's Diversity, and Simpson's Diversity Index. An AR(1) time series model was used to investigate proportional changes in each guild over 25 years. To evaluate the effect of invasive Carp species in invaded reaches, a Chow test was applied to observations between 2000 and 2005. Analyses revealed differences in the functional fish community among reaches. We found differences in functional diversity metrics among study reaches, but there was little evidence that this differed between invaded and non‐invaded reaches. Results determined that invertivore/detritivores have been consistently declining system‐wide, with few groups showing a net change. There was also little evidence that invasion altered the proportion of any functional guild. Evaluating the spatial–temporal patterns of functional communities is beneficial to understanding the resilience of a system and can provide further insight into its trophic needs when considering future restoration initiatives.
Modeling of Preload Bolted Flange Connection Structure for Loosening Analysis and Detection

The specified finite element model is proposed for preload bolted flange connection structure widely used in aerospace and rocket design. A fine hexahedral mesh model of the bolt is used to predict the dynamic response of the structure accurately. The tightening process, which is ignored in the traditional I-shaped simplified model of bolted flange connection structure, can be simulated well based on the proposed model. After the vibration analysis and stress analysis of the bolted flange connection structure under impact load, it is found that the change of contact state of the flange surface results in a larger sticking contact area. And the reduction of the contact area at the thread causes slippage when the bolt is loose. As bolt loosening leads to changes in the time and frequency domain of response, a new loosening detection method for the preload bolted flange connection is provided. The index for identifying the loosening is designed using empirical mode decomposition and discrete integral in the high-frequency domain. The experiment of the preload bolted flange connection structure under impact load shows the efficiency of the proposed method which can identify loosening based on acceleration signal quickly and nondestructively.
Non-isothermal flow past a heated circular cylinder in subcritical regime: a numerical investigation based on large-eddy simulation

Compressible flow past a heated circular cylinder at subcritical Reynolds number of 3900 is numerically investigated by using the large-eddy simulation method. Rigorous validations of the numerical model are carefully performed under isothermal conditions on the basis of available experimental data. The calculated mean flow and Reynolds stresses show good agreement with the published experimental data. The effects of temperature difference between the cylinder surface and the freestream on the flow statistics and thermal characteristics are further studied in detail by setting two kinds of wall temperature boundary conditions. It is manifested that increasing the wall temperature leads to the augmentation of skin friction drag, suppression of turbulent intensity, enhancement of flow mixing and extension of recirculation zone. In addition, it is found that the variations of thermo-physical properties pose a slight effect on the wall heat flux before the boundary layer separates from the cylinder surface. It is worth noting that the recirculation bubble length can be used as a distance scaling parameter to weaken the temperature dependence of the flow and thermal statistics. These results provide a more detailed insight into the statistical difference in the wake region of cylinder when the temperature effect is taken into account.