Miracle-dz/UniFAR-FTUs huggingface dataset:
COVID-19 Pandemic Reduced Utilization Of Interventional Techniques 18.7% In Managing Chronic Pain In The Medicare Population In

on US healthcare and increasing costs over the recent years in managing low back and neck pain as well as other musculoskeletal disorders. The COVID-19 pandemic has affected many modalities of treatments, including those related to chronic pain management, including both interventional techniques and opioids. While there have not been assessments of utilization of interventional techniques specific to the ongoing COVID-19 pandemic, previous analysis published with data from 2000 to 2018 demonstrated a decline in utilization of interventional techniques from 2009 to 2018 of 6.7%, with an annual decline of 0.8% per 100,000 fee-for-service (FFS) in the Medicare population. During that same time, the Medicare population has grown by 3% annually.
The Effects of Intelectin-1 on Antioxidant and Angiogenesis in HUVECs Exposed to Oxygen Glucose Deprivation

Objective: Ischemic stroke leads to cellular death and tissue damage by depriving the areas of glucose and oxygen supplies. The effective treatment of stroke remains a challenge for modern medicine. This study used an oxygen-glucose deprivation (OGD) model of human umbilical vein endothelial cells (HUVECs) to mimic ischemic injuries and explored the role and mechanism of intelectin-1. Methods: Intelectin-1 was transduced into the HUVECs using a lentiviral vector. The PI3K/Akt signaling was examined in intelectin-induced eNOS phosphorylation. The PI3K inhibitor LY294002 was dealed in HUVECs. Results: Our results demonstrated an increase in capillary density, decrease in apoptotic cells, and increase in HIF-1α protein expression following intelectin-1 treatment. Real-time PCR and Western blotting revealed the increased intelectin-1 expression alongside eNOS and Akt phosphorylation with enhanced bcl-2 expression under OGD. Capillary density decreased significantly after LY294002 treatment. Conclusion: These results suggest intelectin-1 promotes angiogenesis, inhibits oxidative stress and reduces apoptosis by stimulating the Akt-eNOS signaling pathway in response to ischemia in vitro.
InactivationIdentifies Oxidative Mechanism of Catalase Nitrotyrosine Proteome Survey in Asthma

Reactive oxygen species and reactive nitrogen species produced by epithelial and inﬂammatory cells are key mediators of the chronic airway inﬂammation of asthma. Detection of 3-nitrotyrosine in the asthmatic lung conﬁrms the presence of increased reactive oxygen and nitrogen species, but the lack of identiﬁcation of modiﬁed proteins has hindered an understanding of the potential mechanistic contributions of nitration/oxidation to airway inﬂammation. In this study, we applied a proteomic approach, using nitrotyrosine as a marker, to evaluate the oxidation of proteins in the allergen-induced murine model of asthma. Over 30 different proteins were targets of nitration following allergen challenge, including the antioxidant enzyme catalase. Oxidative modiﬁcation and loss of catalase enzyme function were seen in this model. Subsequent investigation of human bronchoalveolar lavage ﬂuid revealed that catalase activity was reduced in asthma by up to 50% relative to healthy controls. Analysis of catalase isolated from asthmatic airway epithelial cells revealed increased amounts of several protein oxidation markers, including chloro-and nitrotyrosine, linking oxidative modiﬁcation to the reduced activity in vivo. Parallel in vitro studies using reactive chlorinating species revealed that catalase inactivation is accompanied by the oxidation of a speciﬁc cysteine (Cys 377 ). Taken together, these studies provide evidence of multiple ongoing and profound oxidative reactions in asthmatic airways, with one early downstream consequence being catalase inactivation. Loss of catalase activity likely ampliﬁes oxidative stress, contributing to the chronic inﬂammatory
RUNNING HEAD: Asperger Syndrome and Writing 1 Writing, Asperger Syndrome and Theory of Mind

This research compared the written compositions of 16 adults with high-functioning autism spectrum disorders and 16 neurotypical control participants, and examined the influence of theory of mind on their writing. Participants ranging in age from 17 years to 42 years, matched on Vocabulary subtest scores from the Wechsler Adult Intelligence Scale (1997), completed the Social Attribution Task and wrote an expository and a narrative text. Texts were assessed on 18 variables representing quality, mechanics, and length. It was found that adults with HFASD wrote lower quality narrative and expository texts, and narratives of shorter length. Theory of mind was positively associated with writing quality and text length across both genres.
Surface modification to enhance photo-stability of polymers

Photo-degradation is an irreversible alteration in the chemical, mechanical and physical properties of polymers, these alterations are a result of photon absorption from sunlight. UV-light is considered to be the main factor for initiating photo-degradation process of polymers. To extend the lifetime of polymers, their durability, overall minimization of the rate of photo degradation and protection of polymers against environmental factors, stabilizers are introduced to polymers. In addition, since the interaction of the polymer with its environment occurs mainly at the surface of the polymer, therefore surface modification of polymers is used to enhance the UV photo-stabilization. This method can also provide a more durable, weather resistant and photo-stable polymers.
A Rapid Antimicrobial Susceptibility Test for Determining Yersinia pestis Susceptibility to Doxycycline by RT-PCR Quantification of RNA Markers

Great efforts are being made to develop new rapid antibiotic susceptibility tests to meet the demand for clinical relevance versus disease progression. This is important especially in diseases caused by bacteria such as Yersinia pestis, the causative agent of plague, which grows rapidly in vivo but relatively slow in vitro. This compromises the ability to use standard growth-based susceptibility tests to obtain rapid and proper antibiotic treatment guidance. Using our previously described platform of quantifying antibiotic-specific transcriptional changes, we developed a molecular test based on changes in expression levels of doxycycline response-dependent marker genes that we identified by transcriptomic analysis. This enabled us to determine the minimal inhibitory concentration of doxycycline within 7 h compared to the 24 h required by the standard CLSI test. This assay was validated with various Y. pestis strains. Moreover, we demonstrated the applicability of the molecular test, combined with a new rapid bacterial isolation step from blood cultures, and show its relevance as a rapid test in clinical settings.
J. Gen. Appl. Microbiol., 57, 231‒242 (2011)

Kurtzman and Robnett (1998) observed that, in a tree based on the D1/D2 domain sequences of the large subunit (LSU) rRNA genes, the genera Metschnikowia, Clavispora, Yarrowia and Cyniclomyces were weakly associated and characterized by highly divergent species. They reported that inclusion of several undescribed species considerably shortened some terminal branches, which suggests that the genera in this group have numerous missing taxa. Generally speaking, many known species of the Clavispora-Metschnikowia clade consist of only a limited number of strains and are assumed to be rare in the natural environment. During the course of a study of yeasts living in the natural environment of Thailand, we found several undescribed species in the Clavispora-Metschnikowia clade; however, in many cases, the species are represented only by single strains. We hesitated to describe these strains as novel species. However, Kurtzman (2007) described four anamorphic novel species based on respective single strains and stated that J. Gen. Appl. Microbiol. , 57, 231‒242 (2011)
Temporal and Spatial Variation in Species Composition and Abundances of Ichthyoplankton in Masan Bay

A total of 4 pelagic eggs and 24 larval fish species were collected in Masan Bay. Engraulis japonicus eggs predominated in pelagic eggs. Abundant larval fishes were Omobranchus elegans, Scomber japonicus, Acanthogobius flavimanus, Hexagrammos otakii, Repomucenus sp. , Scartella cristata and Gobiidae sp. , and these 7 species accounted for 78.5% in the total number of individuals. Temporal and spatial variation in both species composition and abundance of was large: the peak abundances of pelagic eggs and larval fishes occurred in July 2007, whilst these were lowest in February 2007. Higher abundance of ichtyoplankton were at station 5 than those of other stations. Temporal changes in the abundances of pelagic eggs and larval fishes corresponded with temperature. Pelagic eggs and larval fishes varied among stations between with shallower inner stations and deeper outer stations with physical characteristics such as depth and local topography.
The Role of Authentic Leadership and Teachers’ Organizational Commitment on Organizational Citizenship Behavior in Higher Education

Several studies highlight the significant role of authentic leadership and followers' organizational commitment on organizational citizenship behavior in business organizations. However, the study of the constructs in the context of educational organization was given less attention in the current literature. This research was intended to assess the influence of authentic leadership and organizational commitment on organizational citizenship behavior in higher education institutions using a quantitative approach and a descriptive survey research design. The collected data from 150 college teacher respondents in the Philippines and hypotheses were assessed using SPSS and Structural Equation Modeling (SEM) AMOS software. The results of this research revealed that authentic leadership and teachers' organizational commitment significantly influence organizational citizenship behavior. The results also depicted that authentic leadership significantly affects organizational commitment. Results yielded that authentic leadership has an indirect influence on organizational citizenship behavior through organizational commitment. This study provides new insights to educational leaders, scholars, and practitioners on the significance of leaders’ authentic leadership on teachers' organizational commitment and organizational citizenship behavior in educational organizations and the significance of leader-teacher relationships in the
Emergence of Quality Low-Dose-Rate (LDR) Brachytherapy: Ultimate Radiosurgery for Non-Metastatic Prostate Cancer

Current advents of new technology in prostate cancer treatment still carries many problems regarding oncological outcome: Local control remains elusive, with biochemical failure ultimately occurring in half of the patients diagnosed by PSA screening. Failure of the initial treatment imposes many kinds of physical, psychological, and economical burdens on the patients, such as toxicities caused by salvage hormonal therapy or radiotherapy, risk for developing Castration-Resistant Prostate Cancer (CRPC), and financial insecurity after second or third salvage drug therapy. Considering these potential adverse effects, physicians should conduct prostate cancer treatment with the utmost care and attention to details. In order to minimize local recurrence the author has invented a novel technique, called the “Ten-Step Method,” for seed implantation that can disseminate quality high-dose radiation. In this review, the author summarizes technique, application and oncological outcome of the high-quality high-dose, Low-Dose-Rate (LDR) branchy therapy that can minimize local recurrence of prostate cancer.
Teachers ’ Perceptions on the Literacy Skills of 5 th Grade Primary School Students During Covid-19 Pandemic in Mandailing Natal

This study aims to discover the literacy skills of 5 grade primary school students during Covid-19 outbreak in Mandailing Natal Regency based on teachers’ perceptions. Descriptive qualitative approach was applied with a simple quantitative support in form of percentages. The respondents in this study were 23 primary school teachers of fifth year class from 23 different primary schools located in 23 districs in Mandailing Natal Regency. To obtain the data, a semi structured interview was conducted adapted from four literacy skills consisting of listening, speaking, reading and writing. The obtained data subsequently were analyzed by thematic analysis based on specific separated themes. The findings demonstrated four results; (1) in listening skill, dominantly, 11 (48%) teachers thought that students’ literacy level is average and for higher level of listening 11 (48%) teachers shared low. (2) in speaking, 11 (48%) teachers stated average and for higher level, 13 (57%) teachers assumed low. (3) in reading, 12 (52%) teachers noted average, and (4) in writing, 11 (48%) teachers perceived average and for higher level, (52%) 12 of teacher-respondents responded that students’ literacy skills were average. Based on these results, it is highly expected to be worthwhile for teachers, lecturers, academician, stakeholders and public community to anticipate and to develop the students’ literacy development by supporting and facilitating the students’ fundamental needs such as children books, complete and comfortable school library, providing reading corner and ensuring teachers’ mastery on digital literacy platforms amidst Covid-19 pandemic and in the coming years, as well. Article History Received: 17-04-2022 Revised: 11-05-2022 Accepted: 23-05-2022 Published: 04-06-2022
FIRM RISK AND CORPORATE POLICIES: FROM THE SHARIAH CERTIFICATION PERSPECTIVE

In this study, we show that Shariah certification leads to risk-reduction benefits. Shariah-compliant firms are negatively related to firm risk; and tolerate lower risk than non-Shariah-complaint firms. This evidence is in line with Shariah principles that prohibit controversial business activities and uncertainties. In brief, excessive risk-taking is discouraged. Therefore, Shariah-compliant firms need to be selective in making investment decisions. We further find that the negative relation applies particularly to Shariah-compliant firms that managed to retain their Shariah-compliant status in the subsequent reviews. This implies that these firms consistently maintain lower level of risk to retain their Shariah status. In terms of the corporate policies, we do not find evidence that Shariah-complaint firms employ conservative financial and operating leverages to mitigate their firm risk. Instead, Shariah-compliant firms emphasize on capital expenditures that lead to lower firm risk. Taken together, our results recommend that Shariah-screening process can be a significant mechanism to mitigate excessive risk.
WIKTOR JASSEM, The Phonology of Modern English Warsaw: Paristwowe

This prodigious volume, five centimeters thick, which must contain well over 200,000 words is "primarily addressed to university students of English" and attempts to give them a "reasonably broad view of the phonology of Modern English, especially present-day English". Professor Jassem says he has tried to combine in it the "high regard for phonetic detail and pragmatism of the London school of phonetics with the severe theoretical rigour of post-Bloomfieldian structuralism. "
J. Gen. Appl. Microbiol., 51, 57–64 (2005)

Sulfate-reducing bacteria (SRB) are of great significance in the final step of carbon recycling and in the sulfur cycle in anaerobic ecosystems. SRB are found mainly in marine and freshwater sediments and sewage sludge, but were also isolated from the intestinal tract of humans, ruminants and pigs (Gebhart et al., 1993; Gibson et al., 1988a, b; Howard and Hungate, 1976; Sass et al., 1998). In anaerobic marine sediments these bacteria can catalyze more than 50% of the total carbon oxidation (Jørgensen, 1982). SRB were found beside methanogens and homoacetogens as a further H2-utilizing bacterial group in the gut of higher and lower termites and in the wood-eating cockroach Cryptocercus punctulatus (Brauman et al., 1990; Fröhlich et al., 1999; Kuhnigk et al., 1996; Ohkuma and Kudo, 1996; Trinkerl et al., 1990) and as ectosymbionts of anaerobic ciliates (Fenchel and Ramsing, 1992). In vitro and in vivo sulfate reduction in the gut contents of the termite Mastotermes darwiniensis and the rose-chafer Pachnoda marginata
This is a repository copy of To Deliver or Not to Deliver Cognitive Behavioral Therapy for Eating Disorders: Replication and Extension of Our Understanding of Why Therapists Fail

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Air Density Measuring Device-Innovative Design, Calibration and Exemplary Results

Received: 9 June 2020 Accepted: 3 November 2020 Air density is a parameter used in numerous applications. Its correct determination can have a key impact on the outcome of an experiment. In calculation of the drag coefficient or pneumatic piping energy loss air density value is crucial for obtaining accurate results. In order to precisely measure this parameter, the electronic air density measuring device was designed and built. The following article presents design, construction, calibration and tests of the mentioned device. The device was designed with a target of reaching set assumptions. It was constructed with open-source programming environment and easily accessible components. Calibration of the device’s sensors was performed in order to ensure high accuracy of results. Calibration of the humidity sensor was performed with use of saturated salt solutions. Exemplary measurement was made to ensure device performance. Created tool provides excellent and cheap fulfillment of the assumptions set in the article.
THE STRUCTURE OF ω-LIMIT SETS OF ASYMPTOTICALLY NON-AUTONOMOUS DISCRETE DYNAMICAL SYSTEMS

We consider a discrete non-autonomous semi-dynamical system generated by a family of continuous maps defined on a locally compact metric space. It is assumed that this family of maps uniformly converges to a continuous map. Such a non-autonomous system is called an asymptotically autonomous system. We extend the dynamical system to the metric one-point compactification of the phase space. This is done via the construction of an associated skew-product dynamical system. We prove, among other things, that the omega limit sets are invariant and invariantly connected. We apply our results to two populations models, the Ricker model with no Allee effect and Elaydi-Sacker model with the Allee effect, where it is assumed that the reproduction rate changes with time due to habitat fluctuation.
Hydraulic characteristics of sewage treatment units

A critical presentation of the hydraulic characteristics of the main units of Sewage Treatment Plants (STP) is performed. The paper consists of three parts. In the first part the main theoretical parameters (related to the hydraulics of the STP units) are presented, together with their scope and their use in the design. The second part deals with the determination and application in the design of more representative hydrodynamic information, such as the detailed flow field and the Flow Through Curve (FTC). In the third part conclusions are drawn and suggestions are made for a realistic design of the STP units.
Bioscience of Microbiota, Food and Health

1Department of Sports and Health Sciences, Faculty of Health and Medical Sciences, Aichi Shukutoku University, 2-9 Katahira, Nagakute, Aichi 480-1197, Japan 2Graduate School of Human Cultures, The University of Shiga Prefecture, 2500 Hassaka-cho, Hikone, Shiga 522-8533, Japan 3Department of Home Economics and Technology Education, Hokkaido University of Education, 9 Hokumon-cho, Asahikawa, Hokkaido 070-8621, Japan
University of Alberta

Peroxisomes are single-membrane-bound ubiquitous organelles required for several important metabolic pathways like lipid metabolism and peroxide detoxification. They are indispensable for normal human development, because lack of metabolically functional peroxisomes causes fatal peroxisome biogenesis disorders (PBDs). In this study, 14 putative Drosophila melanogaster (D. melanogaster) homologs of known PEX genes were identified using a dsRNA interference screen in cultured D. melanogaster S2 cells. In humans, mutations of the PEX1 gene are the most common cause of the PBD, Zellweger syndrome. Further, detailed phenotypic characterization of the D. melanogaster PEX1 homolog (DmelPex1) showed that it is required for complete larval development. DmelPex1 mutant larvae exhibit abnormalities similar to those observed in Zellweger syndrome patients, including developmental delay, poor feeding, structural abnormalities in the peripheral and central nervous systems, and premature death. Overall, this study supports the use of D. melanogaster as an invaluable model for the PBDs.
Characterization of Plasma and Prolactin Receptor in Lactating Intracellular Membrane Mouse Mammary Cells

Mammary cells were prepared from lactating mice by collagenase digestion in order to examine the reaction of prolactin (PRL) with its cellular receptors. Cells were treated with 10% acetic acid following PRL binding. Between 5 and 12.5% acetic acid, the dissociation of PRL remained constant. The ratio of dissociated PRL was comparable to that of tissue slices or disrupted cells with this treatment. In subcellular membranes, about 81% of PRL bound to plasma membrane receptors was dissociated by acid treatment while PRL dissociated from intracellular membrane receptors was about 21%. Based on the nature of their PRL dissociation, PRL receptors were classified as acid-sensitive or acidinsensitive. The reaction of PRL with either species was reversible and saturable, and was dependent on temperature and time. Both species showed high PRL-binding affinity. However, acid-insensitive receptor was unstable at 37°C. The level of acid-sensitive receptor was close to that of acid-insensitive receptor in late pregnancy. During the first 3 days of lactation, the level of acid-sensitive receptor increased more slowly than that corresponding to acid-insensitive receptor. The above criteria suggest that the postpartum increase in PRL binding is characterized especially by an increase in the level of acid-insensitive PRL receptor located mainly on intracellular membrane.
MORE NEW RESULTS ON INTEGRAL INEQUALITIES FOR GENERALIZED K -FRACTIONAL CONFORMABLE INTEGRAL OPERATORS

This paper aims to investigate the several generalizations by newly proposed generalized K -fractional conformable integral operator. Based on these novel ideas, we derived a novel framework to study for ˘ C eby˘ s ev and P´ o lya-Szeg¨ o type inequalities by generalized K -fractional conformable integral operator. Several special cases are apprehended in the light of generalized fractional conformable integral. This novel strategy captures several existing results in the relative literature. We also aim at showing important connections of the results here with those including Riemann-Liouville fractional integral operator.
This is a repository copy of Efficacy of soluble fibre, antispasmodic drugs, and gut–brain neuromodulators in irritable bowel syndrome: a systematic review and network

eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs (CC BY-NC-ND) licence. This licence only allows you to download this work and share it with others as long as you credit the authors, but you can’t change the article in any way or use it commercially. More information and the full terms of the licence here: https://creativecommons.org/licenses/