Miracle-dz/UniFAR-FTUs huggingface dataset:
Impaired Autophagy Response in Hepatocellular Carcinomas Enriches Glypican-3 in Exosomes, Not in the Microvesicles

Background and Aim HCC development in liver cirrhosis is associated with impaired autophagy leading to increased production of extracellular vesicles (EVs) including exosomes and microvesicles. The goal of the study is to determine which of these particles is primarily involved in releasing of HCC-specific biomarker glypican-3 (GPC3) when autophagy is impaired. Methods Streptavidin-coated magnetic beads were coupled with either biotinylated CD63 or Annexin A1 antibodies. Coupled beads were incubated with EVs isolated from either HCC culture or serum. EVs captured by immuno-magnetic beads were then stained with FITC or PE fluorescent-conjugated antibodies targeting exosomes (CD81), and microvesicles (ARF6). The percentage of GPC3 enrichment in the microvesicles and exosomes was quantified by flow cytometry. The impact of autophagy modulation on GPC3 enrichment in exosomes and microvesicles was assessed by treating cells with Torin 1 and Bafilomycin A1. For clinical validation, GPC3 content was quantified in microvesicles, and exosomes were isolated from the serum of patients with a recent HCC diagnosis. Results The immune-magnetic bead assay distinguishes membrane-derived microvesicles from endosome-derived exosomes. The GPC3 expression was only seen in the CD63 beads group but not in the Annexin A1 beads group, confirming that in HCC, GPC3 is preferentially released through exosomes. Furthermore, we found that autophagy induction by Torin1 decreased GPC3-positive exosome secretion and decreased microvesicle release. Conversely, autophagy inhibition by Bafilomycin A1 increased the secretion of GPC3-positive exosomes. Serum analysis showed CD81+ve EVs were detected in exosomes and ARF6+ve vesicles were detected in microvesicles, suggesting that immunoaffinity assay is specific. The exosomal GPC3 enrichment was confirmed in isolated EVs from the serum of patients with HCC. The frequency of GPC3-positive exosomes was higher in patients with HCC (12.4%) compared to exosomes isolated from non-cirrhotic and healthy controls (3.7% and 1.3% respectively, p<0.001). Conclusion Our results show that GPC3 is enriched in the endolysosomal compartment and released in exosome fractions when autophagy is impaired.
Computer network intrusion detection system matching algorithm

In order to guarantee network security effectively and improve the performance and efficiency of computer network intrusion detection system, the matching algorithm of computer network intrusion detection system is studied. Firstly, the basic model of computer network intrusion detection is analyzed, and the multi-pattern matching algorithm of computer network intrusion detection system is proposed, which is integrated into the computer network. Then, the multi-pattern matching algorithm of computer network intrusion detection system is analyzed, and a computer network intrusion detection system based on the multi-pattern matching algorithm is designed, and the multi-pattern matching algorithm is improved to improve its effectiveness. Finally, an algorithm satisfying the requirements of computer network intrusion detection system is obtained by comparing with the conventional matching algorithm. Through the research of matching algorithm applied to computer network intrusion detection system, it shows certain social practicability.
On the angular momentum of photons: effects of transversality condition on the quantization of radiation fields

The notion of intrinsic system of coordinates is introduced for the photon from the constraint of transversality condition. The degree of freedom to specify the intrinsic system is extracted from the same constraint, which turns out to be responsible for the spin Hall effect of light. It is shown that the fundamental quantization conditions that break down in the laboratory system of coordinates restore in the intrinsic system, which make it realizable to canonically quantize the radiation field. It is also shown that the dependence of the intrinsic system on the momentum underlies the noncommutativity of photon position in the laboratory system. The commutation relations of the spin and orbital angular momentum that were found by van Enk and Nienhuis [J. Mod. Opt. \textbf{41}, 963 (1994)] in a second quantized theory are re-derived in the present first quantized theory.
A compact dipole driven ring base station antenna for full sub‐6 GHz band applications

In this article, a compact dual‐band antenna is presented for sub‐6 GHz base station applications. The main radiator of the antenna is composed of ring‐shaped dipoles and Y‐shaped dipoles. Broadband impedance matching is achieved by complementarily coupling between the two types of dipoles. The measured results show the bandwidth of the proposed antenna can cover from 2.06 to 3.69 GHz in the low‐frequency band with an around isolation of 30 dB, and cover from 4.79 to 5.02 GHz in the high‐frequency band with an around isolation of 25 dB. The in‐band peak realized gain is 9.12 ± 1.02 dBi. Since the proposed antenna operates at N41, N78, and N79 bands in China, it can be a potential element for full sub‐6 GHz base station applications.
Steps toward interstellar silicate mineralogy - VI. Dependence of crystalline olivine IR spectra on iron content and particle shape

Crystalline olivines are an important component of silicate dust particles in space. ISO observations revealed the presence of crystalline silicates in comets, protoplanetary accretion disks, and outflows from evolved stars. For the interpretation of astronomical spectra, the relevant material data at a variety of temperatures and over a broad wavelength range, are urgently needed. In contrast to this need, optical properties of the astronomically interesting olivines are scarcely available at present. In order to close this gap, we studied the optical properties of three minerals of the olivine group by reflection spectroscopy on single crystals in the infrared spectral range. We measured the iron endmember (fayalite, $\rm Fe_2SiO_4$), an Mg-rich olivine ($\rm Mg_{1.9}Fe_{0.1}SiO_4$), and the magnesium endmember (forsterite, $\rm Mg_2SiO_4$) of the $\rm (Mg,Fe)_2SiO_4$ series. For a direct comparison with astronomical observations, we present calculated mass absorption coefficients in the Rayleigh limit for different shapes and varying iron content of the dust particles. The laboratory data together with a set of ISO data for envelopes around evolved stars (Molster 2000) are used to constrain the properties of circumstellar silicates. We find that essentially all band positions are shifted to larger wavelengths with increasing iron content. The particle shape influences very significantly the strong bands such as the B$_{1u}$:$\nu_3$ mode that appears as the "11.4 μ m" band of forsterite, whereas e.g. the two FIR modes longward of 40 μ m remain practically unaffected by the particle shape but shift due to increasing iron content. The comparison with the band positions in ISO spectra points to the presence of olivine crystals strongly elongated along the crystallographic c -axis. In addition, we apply the calculated mass absorption coefficients to evaluate transmission measurements of particles embedded in a matrix -a technique which is frequently used in laboratory astrophysics. All data shown in this paper will be made available in digital form via the electronic database http://www.astro. uni-jena.de.
IDENTIFY THE NATURAL FREQUENCIES OF STRUCTURES BY FREQUENCY DOMAIN DECOMPOSITION METHOD

Natural frequencies are important dynamic characters of building structures and can be determined by analytical or experimental methods. Over time, under the effect of loads, environment, random factors. , the characteristics of the building structure are changed, leading to a change in the dynamic characteristics. The paper presents how to determine the natural frequencies of the building structures by the frequency domain decomposition (FDD) method. This method belongs to the group of Operational Modal Analysis (OMA) method, which only uses vibration measurement data of structures to determine the natural frequencies without knowing forces acting on the structure.
The Applicability of Classic Capital Asset Pricing Model in Chinese Stock Market

China has been one of the largest emerging markets and the second-largest economy in the world since the ‘Reform and Opening-up’ in 1978. However, because of the late development, Chinese financialization is still at a developing stage, and the Chinese stock market opened its first trade in 1989. By contrast, the New York Stock Exchange (NYESE) started in 1789. During these years of development, some models have been built to value the price of assets. The classic Capital Asset Pricing Model (CAPM) was a famous one raised by American scholar Sharpe in 1964, which is a model that indicates the relationship between the expected return of an asset or portfolio and the systematic risk of the market. The classic CAPM model’s applicability has been tested practically in the US. However, China has a different system and a much younger age compared to the financial market in the US. Thus, this paper is going to investigate whether the CAPM model could be applied to Chinese market. The discussion will investigate the CAPM capabilities by referring to scholars’ statistical studies. This paper will provide some statistical analysis and evaluate these methods by comparing Chinese and US markets, which leads to this paper’s conclusion: the CAPM model does not fit into the current Chinese stock market.
Features of the exponential form of internal heat generation, Cattaneo–Christov heat theory on water‐based graphene–CNT–titanium ternary hybrid nanofluid flow

To increase energy efficiency, the flow of fluids containing nanoparticles is crucial in industrial applications notably in nuclear reactors and nuclear system cooling. In light of this, this study examines the flow of a water‐based ternary hybrid nanofluid (graphene, single‐walled carbon nanotubes, and titanium dioxide) across a curved stretching sheet with suction. The non‐Fourier heat flux model is also considered in the modeling. The existing partial differential equations are converted into ordinary differential equations through the use of similarity variables. These ordinary differential equations are then numerically solved using the Runge–Kutta–Fehlberg fourth‐ and fifth‐order method along with a shooting approach. The collection of graphical findings for the key variables on the temperature and velocity profiles is investigated. Results reveal that the heat transport in ternary hybrid nanoliquid rises as the heat source/sink parameter rises. The Biot number influences the thermal profile positively, whereas the increasing curvature parameter values reduce heat transport. The curvature parameter has a positive impact on skin friction but the suction parameter has a negative impact on skin friction.
Healing the wounds of workplace bullying: Evaluating mental health and workplace participation among victims seeking treatment for common mental disorders

BACKGROUND: Victims of workplace bullying represent a group characterised by severe negative health complaints at risk of losing their foothold in working life. To date, very few studies have investigated the effect of psychological treatment of the health-related problems often facing victims of bullying. OBJECTIVE: The aim was to investigate if victims of workplace bullying suffering from common mental disorders (CMD) benefit from clinical treatment for their mental health problems at an outpatient clinic treating patients using Metacognitive or Cognitive Behavioural Therapy with work-focus. Criteria were symptom reduction and change in workplace participation. Comparisons were made between the victims of workplace bullying with CMD, a wait-list control group consisting of patients who had also been exposed to bullying yet now awaiting treatment, and other patients not exposed to bullying. METHODS: The sample comprised of 405 patients from an outpatient clinic in Norway. The study used a naturalistic observational design and data was collected pre-treatment and post-treatment. RESULTS: The results showed the treatment to be effective in symptom reduction for victims of bullying to a similar degree as patients otherwise not exposed to bullying. Even more, victims receiving treatment had a larger improvement compared to the wait-list control group (p < 0.001). Yet, among patients on sick leave pre-treatment, fewer victims of bullying were fully working by the end of treatment compared to the patients not exposed to workplace bullying. CONCLUSION: The findings provide ground for optimism for this treatment as an efficient way of dealing with the aftermath of workplace bullying.
Antecedents Experiential Commitment and Consequences in Willingness to Post Photo and Behavioral Intention Toward the Destination

The purpose of this study was to examine whether Destination Image, Place Attachment, Place Identity, Place Dependence and Experiential Commitment have an effect on Behavioral Intentions toward the destination, willingness to post photos. The population of this study is tourists who visit Labuan Bajo tourism. This study's sample size was 200 people. This is a quantitative study using a survey method. In this study, a questionnaire was used to collect data. Online questionnaires were distributed to domestic tourists who visit Labuan Bajo and the technique sampling using a Non Probability Sampling approach with purposive sampling, with the criteria that tourists visit Labuan Bajo at least once a year. PLS-SEM is used to analyze data. The results showed that there was a positive influence between the variables Destination Image, Place Attachment, Place Identity, Place Dependence, Experiential Commitment, Behavioral Intentions toward the destination, willingness to post photo. Labuan Bajo have an adventure Tourism Activities, cultural Tourism Experience, Culinary Experience (Cruise Dining, Dining with a View), beautiful spot photo and scenery.
Ameliorative Effect of Pomegranate Peel Extract (PPE) on Hepatotoxicity Prompted by Iron Oxide Nanoparticles (Fe2O3-NPs) in Mice

An evaluation of the ameliorative effect of pomegranate peel extract (PPE) in counteracting the toxicity of iron oxide nanoparticles (Fe2O3-NPs) that cause hepatic tissue damage is focused on herein. Forty male albino mice were haphazardly grouped into four groups as follows: the first control group was orally gavage daily with physiological saline; the second group received 100 mg/kg of PPE by the oral route day after day; the third group received 30 mg/kg Fe2O3-NPs orally; and the fourth group received both PPE and Fe2O3-NPs by the oral route, the same as the second and third sets. Later, after the completion of the experiment, we collected the liver, blood, and bone marrow of bone specimens that were obtained for further laboratory tests. For instance, exposure to Fe2O3-NPs significantly altered serum antioxidant biomarkers by decreasing the levels of total antioxidant capacity (TAC), catalase (CAT), and glutathione s-transferase (GST). Additionally, it caused changes in the morphology of hepatocytes, hepatic sinusoids, and inflammatory Kupffer cells. Furthermore, they significantly elevated the number of chromosomal aberrations including gaps, breaks, deletions, fragments, polyploidies, and ring chromosomes. Moreover, they caused a significant overexpression of TIMP-1, TNF-α, and BAX mRNA levels. Finally, the use of PPE alleviates the toxicity of Fe2O3-NPs that were induced in the hepatic tissues of mice. It is concluded that PPE extract has mitigative roles against the damage induced by Fe2O3-NPs, as it serves as an antioxidant and hepatoprotective agent. The use of PPE as a modulator of Fe2O3-NPs’ hepatotoxicity could be considered as a pioneering method in the use of phytochemicals against the toxicity of nanoparticles.
Refining the constant in a maximum principle for the Bergman space

Let A 2 (D) be the Bergman space over the open unit disk D in the complex plane. Korenblum conjectured that there is an absolute constant c, 0 < c < 1, such that whenever |f(z)| < |g(z)| (f, g ∈ A 2 (D)) in the annulus c < |z| < 1, then ∥f∥ ≤ ∥g∥. In this note we give an example to show that c < 0.69472.
Fukaya Floer homology of $\Sigma \times S^1$ and applications

We determine the Fukaya Floer homology of the three-manifold which is the product of a Riemann surface of genus $g\geq 1$ times the circle. This sets up the groundwork for finding the structure of the Donaldson invariants of four-manifolds not of simple type in the future. We give the following applications: 1) We show that every four-manifold with $b^+>1$ is of finite type. 2) Some results relevant to Donaldson invariants of connected sums along surfaces. 3) We find the invariants of the product of two Riemann surfaces both of genus greater or equal than one.
The Challenges of Intensive Care Unit Nurses Caring for COVID-19 Patients in Indonesia: A Qualitative Study

Background: After one year of the pandemic, Indonesia experienced a crisis where the addition of COVID-19 cases increased significantly in several big cities; it made the healthcare system collapse, including the intensive care unit (ICU) service for COVID-19. ICU nurses, who are at the frontline of fighting against COVID-19 and defusing this crisis, are faced with various challenges in providing care for COVID-19 patients, and exploring such challenges are significant. Purpose: This study aimed to explore the challenges experienced by Indonesian nurses who work in the ICU caring for COVID-19 patients.Methods: A multi-centered-qualitative study with a descriptive phenomenological design was used. Twenty nurses working in the ICU of COVID-19 in eight COVID-19 referral hospitals in seven major cities in Indonesia were recruited using purposive sampling. Semi-structured individual video call interviews were conducted to collect the data from July-September 2021. Data were analyzed using Colaizzi’s (1978) method.Results: The nurses reported the challenges throughout caring for COVID-19 patients in ICU, which are described in four major themes: (a) working under pressure and moral distress, (b) choosing to do the best, (c) adaptation, learning, and research, and (e) survive physically and mentally healthy.Conclusion: This study describes the challenges experienced by nurses working in ICUs during the COVID-19 crisis, such as working under pressure, facing dilemmas caring for patients, and trying to survive working in inadequate professional conditions. An in-depth understanding of these challenges in the current pandemic can help managers in the hospital to provide psychological support, adequate training for ICU nurses, and high-quality protocols for upcoming emergency scenarios, as well as maximizing resource management (human and material).
Ablation of Discoidin Domain Receptor 1 Provokes an Osteopenic Phenotype by Regulating Osteoblast/Osteocyte Autophagy and Apoptosis

Discoidin domain receptor 1 (DDR1) is a collagen receptor that belongs to the receptor tyrosine kinase family. We have previously shown that DDR1 plays a crucial role during bone development, resulting in dwarfism and a short stature in osteoblast-specific knockout mice (OKO mice). However, the detailed pathophysiological effects of DDR1 on bone development throughout adulthood have remained unclear. This study aims to identify how DDR1 regulates osteoblast and osteocyte functions in vivo and in vitro during bone development in adulthood. The metabolic changes in bone tissues were analyzed using Micro-CT and immunohistochemistry staining (IHC) in vivo; the role of DDR1 in regulating osteoblasts was examined in MC3T3-E1 cells in vitro. The Micro-CT analysis results demonstrated that OKO mice showed a 10% reduction in bone-related parameters from 10 to 14 weeks old and a significant reduction in cortical thickness and diameter compared with flox/flox control mice (FF) mice. These results indicated that DDR1 knockout in OKO mice exhibiting significant bone loss provokes an osteopenic phenotype. The IHC staining revealed a significant decrease in osteogenesis-related genes, including RUNX2, osteocalcin, and osterix. We noted that DDR1 knockout significantly induced osteoblast/osteocyte apoptosis and markedly decreased autophagy activity in vivo. Additionally, the results of the gain- and loss-of-function of the DDR1 assay in MC3T3-E1 cells indicated that DDR1 can regulate the osteoblast differentiation through activating autophagy by regulating the phosphorylation of the mechanistic target of rapamycin (p-mTOR), light chain 3 (LC3), and beclin-1. In conclusion, our study highlights that the ablation of DDR1 results in cancellous bone loss by regulating osteoblast/osteocyte autophagy. These results suggest that DDR1 can act as a potential therapeutic target for managing cancellous bone loss.
Microseismic Constraints on the Mechanical State of the North Anatolian Fault Zone 13 Years After the 1999 M7.4 Izmit Earthquake

The 17 August 1999 Mw7.4 Izmit earthquake ruptured the western section of the North Anatolian Fault Zone and strongly altered the fault zone properties and stress field. Consequences of the co‐ and post‐seismic stress changes were seen in the spatio‐temporal evolution of the seismicity and in the surface slip rates. Thirteen years after the Izmit earthquake, in 2012, the seismic network Dense Array for North Anatolia (DANA) was deployed for 1.5 years. We built a new catalog of microseismicity (M < 2) by applying our automated detection and location method to the DANA data set. Our method combines a systematic backprojection of the seismic wavefield and template matching. We analyzed the statistical properties of the catalog by computing the Gutenberg‐Richter b‐value and by quantifying the amount of temporal clustering in groups of nearby earthquakes. We found that the microseismicity mainly occurs off the main fault and that the most active regions are the Lake Sapanca step‐over and near the Akyazi fault. Based on previous studies, we interpreted the b‐values and temporal clustering (a) as indicating that the Akyazi seismicity is occurring in high background stresses and is driven by the Izmit earthquake residual stresses, and (b) as suggesting evidence that an intricate combination of seismic and aseismic slip was taking place on heterogeneous faults at the eastern Lake Sapanca, near the brittle‐ductile transition. Combined with geodetic evidence for enhanced north‐south extension around Lake Sapanca following the Izmit earthquake, the seismicity supports the possibility of slow slip at depth in the step‐over.