Miracle-dz/UniFAR-FTUs huggingface dataset:
CHILDREN’S LEARNING IN ADULTS’ ENVIRONMENT - THE STREET

This paper aims to explore the learning of working children on the streets. This study takes qualitative approach with semi-structured interviews as method. In total, 10 interviews were conducted with key informants aged 12-16 in Rawalpindi city. Social learning theory of Albert Bandura has been used as theoretical frameworks. The main themes are presented through case studies of three children who shared their learning on the streets. It is argued in this paper that children have to work in the streets in an adult environment due to their familial responsibilities especially in COVID-19, and sacrificing studies. And they are working in that environment –the street (an urban space) - which is created by adults and operated by rules and regulations of adults, where children face different exploitation including sexual abuse, discrimination and learning tricks of wrong doings. It is also argued that children can carry all these learning and experiences to rest of their lives and practice wrong doings in their professional lives as well. It is concluded that it is important for adults to give children an environment where moral judgment of right and wrong prevails and children can distinguish them and practice good things in their lives. Keywords: Learning tricks, street, COVID-19, exploitation, moral judgment
1 THE CLIMATE OF THE DOURO : STRUCTURE , TRENDS AND MITGATION AND ADAPTATION RESPONSES TO A CHANGING CLIMATE

The Douro Wine Region has a long history of wine production across a diverse array of landscapes and climates. This research examined the climate structure, variability and trends of climate in the region with the goal to establish a baseline understanding from which changes in climate can be made. Spatial climate data for 1950-2000 shows that the Huglin Index for the region averages 2160, however, due to the diverse terrain, the region spans five different classes suitable for viticulture being 50% a Warm Temperate climate, 35% a Temperate climate, 10% a Warm climate, and 5% a Cool or Very Cool climate. Three long-term stations in the region show greater warming in minimum compared to maximum temperatures with rates ranging from 1.2°C to 3.6°C during 1967-2010. Analysis of extreme events for the three stations reveals significant changes for both maximum and minimum temperature extremes, with overall warmer nights, warmer days, a general decline in the diurnal temperature range, a higher number heat stress events, some evidence for longer warm spells, and a clear reduction in cold spell durations. The region is also dominated by circulation features of the Atlantic-European sector that produce a strong winter-summer contrast in both temperatures and precipitation. Given the few trends in weather regimes, but significant trends in annual, growing season, and dormant season temperatures, the results point to a general warming that is not being significantly driven by regional circulation changes. Future climate conditions in the Douro Wine Region are projected to warm and dry over all emission scenarios (B2, A1B, and A2) and for each time slice examined (2020, 2050, and 2080). However, the Douro Wine Region is rich in landscape and plant characteristics that may help mitigate the deleterious effects of climate change. By following sustainable approaches and being innovative across the entire production system the Douro Wine Region has and will continue to reduce its vulnerability and increase its adaptive capacity in the face of a changing climate.
The Burden of Carbapenem-Resistant Acinetobacter baumannii in ICU COVID-19 Patients: A Regional Experience

Since the beginning of the COVID-19 pandemic, the impact of superinfections in intensive care units (ICUs) has progressively increased, especially carbapenem-resistant Acinetobacter baumannii (CR-Ab). This observational, multicenter, retrospective study was designed to investigate the characteristics of COVID-19 ICU patients developing CR-Ab colonization/infection during an ICU stay and evaluate mortality risk factors in a regional ICU network. A total of 913 COVID-19 patients were admitted to the participating ICUs; 19% became positive for CR-Ab, either colonization or infection (n = 176). The ICU mortality rate in CR-Ab patients was 64.7%. On average, patients developed colonization or infection within 10 ± 8.4 days from ICU admission. Scores of SAPS II and SOFA were significantly higher in the deceased patients (43.8 ± 13.5, p = 0.006 and 9.5 ± 3.6, p < 0.001, respectively). The mortality rate was significantly higher in patients with extracorporeal membrane oxygenation (12; 7%, p = 0.03), septic shock (61; 35%, p < 0.001), and in elders (66 ± 10, p < 0.001). Among the 176 patients, 129 (73%) had invasive infection with CR-Ab: 105 (60.7%) Ventilator-Associated Pneumonia (VAP), and 46 (26.6%) Bloodstream Infections (BSIs). In 22 cases (6.5%), VAP was associated with concomitant BSI. Colonization was reported in 165 patients (93.7%). Mortality was significantly higher in patients with VAP (p = 0.009). Colonized patients who did not develop invasive infections had a higher survival rate (p < 0.001). Being colonized by CR-Ab was associated with a higher risk of developing invasive infections (p < 0.001). In a multivariate analysis, risk factors significantly associated with mortality were age (OR = 1.070; 95% CI (1.028–1.115) p = 0.001) and CR-Ab colonization (OR = 5.463 IC95% 1.572–18.988, p = 0.008). Constant infection-control measures are necessary to stop the spread of A. baumannii in the hospital environment, especially at this time of the SARS-CoV-2 pandemic, with active surveillance cultures and the efficient performance of a multidisciplinary team.
The Mediation Effect of Peripheral Biomarkers of Calcium Metabolism and Chronotypes in Bipolar Disorder Psychopathology

Calcium (Ca++) metabolism may be impaired in several psychiatric diseases. We hypothesize that calcium imbalance might also correlate with a specific chronotype and could be recognized as a marker of illness severity in bipolar disorder (BD). We aimed to (1) identify the association between calcium imbalance and a specific chronotype in a cohort of BD patients, and (2) test the mediation role of high parathyroid hormone (PTH) levels towards a specific chronotype and illness severity in BD patients. Patients’ socio-demographic and clinical characteristics were collected with an ad-hoc schedule. We administered the Hamilton Depression Rating Scale (HAM-D), the Hamilton Rating Scale for Anxiety (HAM-A), the Young Mania Rating Scale (YMRS), and the Morningness Eveningness Questionnaire (MEQ). 100 patients affected by BD were recruited. The Kruskal-Wallis test showed a significant difference between the three MEQ groups in PTH levels (p < 0.001) and vitamin D levels (p = 0.048) but not in Ca++ levels (p = 0.426). Dwass-Steel-Critchlow-Fligner Pairwise analyses performed concerning three MEQ groups revealed significantly higher scores on PTH levels in MEQ-E subjects compared to MEQ-M and MEQ-I (in both cases, p < 0.001). No differences emerged between calcium levels among the three chronotypes. The mediation analysis has shown that elevated PTH levels are directly influenced by more severe HAM-A, HAM-D, and YMRS scores. MEQ-E could be a marker related to BD and predispose to various factors influencing mood symptoms. The combination of vitamin D therapy in MEQ-E may help to improve prognosis in this subtype of patients affected by BD.
Downregulation of senescence-associated secretory phenotype by knockdown of secreted frizzled-related protein 4 contributes to the prevention of skin aging

There is growing evidence that the appearance and texture of the skin that is altered during the aging process are considerably enhanced by the accumulation of senescent dermal fibroblasts. These senescent cells magnify aging via an inflammatory, histolytic, and senescence-associated secretory phenotype (SASP). Secreted frizzled-related protein 4 (SFRP4) was previously determined to be expressed in dermal fibroblasts of aging skin, and its increased expression has been shown to promote cellular senescence. However, its role in the SASP remains unknown. We found that SFRP4 was significantly expressed in p16ink4a-positive human skin fibroblasts and that treatment with recombinant SFRP4 promoted SASP and senescence, whereas siRNA knockdown of SFRP4 suppressed SASP. Furthermore, we found that knockdown of SFRP4 in mouse skin ameliorates age-related reduction of subcutaneous adipose tissue, panniculus carnosus muscle layer, and thinning and dispersion of collagen fibers. These findings suggest a potential candidate for the development of new skin rejuvenation therapies that suppress SASP.
Market Access, Supplier Access, and Africa's Manufactured Exports: An Analysis of the Role of Geography and Institutions

In a large cross-country sample of manufacturing establishments drawn from 188 cities, average exports per establishment are smaller for African firms than for businesses in other regions. The authors show that this is mainly because, on average, African firms face more adverse economic geography and operate in poorer institutional settings. Once they control for the quality of institutions and economic geography, what in effect is a negative African dummy disappears from the firm level exports equation they estimate. One part of the effect of geography operates through Africa's lower"foreign market access:"African firms are located further away from wealthier or denser potential export markets. A second occurs through the region's lower"supplier access:"African firms face steeper input prices, partly because of their physical distance from cheaper foreign suppliers, and partly because domestic substitutes for importable inputs are more expensive. Africa's poorer institutions reduce its manufactured exports directly, as well as indirectly, by lowering foreign market access and supplier access. Both geography and institutionsinfluence average firm level exports significantly more through their effect on the number of exporters than through their impact on how much each exporter sells in foreign markets.
The Well-Being of Primary School Teachers during COVID-19

This study examines the self-rated health and well-being of Icelandic teachers just before and over a year after COVID-19 first appeared. We ask, what was the stress level in 2021 compared to 2019 and the impact of mental and physical health and health symptoms on perceived stress? Were there any changes in self-assessed mental and physical health? Were there any changes in self-assessed mental and physical health symptoms? The study is based on an online survey conducted in 2019 and 2021. A total of 920 primary school teachers answered the questionnaire in part or in full, after three reminders. The main findings show increased stress, worsening mental and physical health, and increasing mental and physical symptoms in 2021 compared to 2019. The results also show a higher percentage of women than men reporting high stress, with women scoring higher on the PSS scale, but the gender patterns for mental and physical health are less clear. The results show that the COVID-19 pandemic had negative consequences on the health and well-being of the teachers. The study demonstrates the importance of school authorities keeping an exceptionally watchful eye on the welfare and well-being of teachers in the wake of the COVID-19 pandemic.
Dietary Quality during Pregnancy and Congenital Heart Defects

Limited studies on maternal dietary quality indices and congenital heart defects (CHD) are available. This study aimed to explore the relationship between dietary quality in pregnancy and CHD among the Chinese population. A case-control study was performed in Northwest China, and 474 cases and 948 controls were included. Eligible women waiting for delivery were interviewed to recall diets and other information during pregnancy. Dietary quality was assessed by the Global Diet Quality Score (GDQS) and Mediterranean Diet Score (MDS). Logistic regression models were adopted to evaluate the associations of dietary quality scores with CHD. Pregnant women with higher scores of GDQS and MDS were at a lower risk of fetal CHD, and the adjusted ORs comparing the extreme quartiles were 0.26 (95%CI: 0.16–0.42; Ptrend < 0.001) and 0.53 (95%CI: 0.34–0.83; Ptrend = 0.007), respectively. The inverse associations of GDQS and MDS with CHD appeared to be stronger among women with lower education levels or in rural areas. Maternal GDQS and MDS had good predictive values for fetal CHD, with the areas under the receiver operating characteristic curves close to 0.8. Efforts to improve maternal dietary quality need to be strengthened to decrease the prevalence of CHD among the Chinese population.
Hypoxia Triggers TAZ Phosphorylation in Basal A Triple Negative Breast Cancer Cells

Hypoxia and HIF signaling drive cancer progression and therapy resistance and have been demonstrated in breast cancer. To what extent breast cancer subtypes differ in their response to hypoxia has not been resolved. Here, we show that hypoxia similarly triggers HIF1 stabilization in luminal and basal A triple negative breast cancer cells and we use high throughput targeted RNA sequencing to analyze its effects on gene expression in these subtypes. We focus on regulation of YAP/TAZ/TEAD targets and find overlapping as well as distinct target genes being modulated in luminal and basal A cells under hypoxia. We reveal a HIF1 mediated, basal A specific response to hypoxia by which TAZ, but not YAP, is phosphorylated at Ser89. While total YAP/TAZ localization is not affected by hypoxia, hypoxia drives a shift of [p-TAZ(Ser89)/p-YAP(Ser127)] from the nucleus to the cytoplasm in basal A but not luminal breast cancer cells. Cell fractionation and YAP knock-out experiments confirm cytoplasmic sequestration of TAZ(Ser89) in hypoxic basal A cells. Pharmacological and genetic interference experiments identify c-Src and CDK3 as kinases involved in such phosphorylation of TAZ at Ser89 in hypoxic basal A cells. Hypoxia attenuates growth of basal A cells and the effect of verteporfin, a disruptor of YAP/TAZ-TEAD–mediated transcription, is diminished under those conditions, while expression of a TAZ-S89A mutant does not confer basal A cells with a growth advantage under hypoxic conditions, indicating that other hypoxia regulated pathways suppressing cell growth are dominant.
House Price Prediction Based on Machine Learning: A Case of King County

This paper focuses on formulating a feasible method for house price prediction. A dataset containing features and house price of King County in the US is used. During the data preprocessing, extreme values are winsorized and highly correlated features are removed. Eight models including Catboost, lightGBM and XGBoost serve as candidate models. They are evaluated by several evaluation indicators, including rooted mean square error, R-squared score, adjusted R-squared score and K-fold cross validation score. The model that has low RMSE, achieves a high R-squared score and adjusted R-squared score, especially in the test set, and acquires a high score in cross validation is considered a better model. This paper finds out that Catboost performs the best among all models and can be used for house price prediction. Location, living space and condition of the house are the most important features influencing house price. After comparison and contrast with other papers, it is attested that findings in this paper conform to real life. This paper formulates a model that fits better than preceding studies for house price prediction and makes necessary supplement to the exploration of features that influence house price from a microscope.
YeSQL: Rich User-Defined Functions without the Overhead

The diversity and complexity of modern data management applications led to the extension of the relational paradigm with syntactic and semantic support for User-Defined Functions (UDFs). Although well-established in traditional DBMS settings, UDFs have become even more central in many applications spanning data science, data analytics, etc. Still, a critical limitation of UDFs, which to some extent has turned data scientists towards NoSQL systems, is the impedance mismatch between their evaluation and relational processing. We present YeSQL, an SQL extension with rich UDF support along with a pluggable architecture to easily integrate it with either server-based or embedded database engines. We currently support UDFs written in Python, which are fully integrated with relational queries as scalar functions, aggregators, or table returning functions. Key novel characteristics of YeSQL include easy implementation of complex algorithms, tracing JIT compilation of Python UDFs, and seamless integration with a database engine. Our demonstration will showcase (a) the usability and expressiveness of our approach, and (b) that our techniques of minimizing context switching between the relational engine and the Python VM are very effective and achieve significant speedups in common, practical use cases.
Analysis of the Slowing Down of High Energy Proton Shots through Matter via a Monte Carlo Simulation of the Fokker Planck Equation

Analyzing the high energy proton diffusion through solid matter rigorously, by using the transfer equation, means to tackle many difficulties most of which arise from the long range nature of the Coulomb interactions, involving more than one particle simultaneously. The commonly used approach of neglecting the multi‐body collisions, though correct for rarefied neutral gases, often leads to very poor approximations, when charged particles moving through dense matter are considered. Here we present a numerical simulation of the Fokker‐Planck equation where the multi‐body collisions are taken into account. The model allows to calculate point‐wise the distribution of energy and momentum transferred to the target.
Effect of Nail Grips on Weight Bearing and Limb Function in 30 Dogs 2 Weeks Post Tibial Plateau Leveling Osteotomy

Simple Summary Devices made to improve mobility are becoming increasingly popular among owners of dogs with orthopedic conditions, but there are few studies investigating their efficacy. Nail grips are commonly used by veterinary rehabilitation practitioners to improve the security of foot placement by increasing nail traction. This study aimed to assess if nail grips would improve mobility outcomes in dogs recovering from knee surgery. The results did not show a significant effect on outcomes during the initial 2-week post-operative period; however, further research is needed to determine if they are useful for other applications. Abstract The objective of this study was to assess the functional outcomes of dogs wearing nail grips in the first 2 weeks following tibial plateau leveling osteotomy (TPLO). Thirty dogs were included (n = 13 nail grips and n = 17 sham grips). Visual lameness scores (VLS), total pressure index (TPI), and client-specific outcome measures (CSOMs) were obtained by blinded observers on day 1 and day 14 +/− 3 post TPLO. CSOMs were also obtained on day 7. There were no differences in VLS and TPI between the treatment and sham group on day 14 (p = 0.44 and p = 0.59, respectively) or at any time point. CSOMs assessing walking on slippery flooring, ability to rise, and consistent use of surgical limb on a 5 min walk were also not different between groups (p = 0.78, p = 0.80, and p = 0.63) at any time point. Nail grips were well tolerated in dogs after orthopedic surgery. This study did not demonstrate a benefit for dogs wearing nail grips during the first two weeks after TPLO; however, further studies are warranted.
Differences in event-related potential (ERP) among small tie, non-tie and 1-problems in addition and multiplication

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Agave americana: Characteristics and Potential Breeding Priorities

Agave americana L. is one of many Agave species that could be developed for the production of valuable agricultural products. Although all species in this genus use Crassulacean Acid Metabolism (CAM) and most have drought and heat tolerance, Agave americana also has the combined traits of high yield and cold tolerance. This review highlights key characteristics of Agave americana that make it an exceptional novel crop for fiber, sweeteners, bioproducts, and bioethanol with resilient traits for changing climate conditions. Then, it proposes potential directions for breeding that will support production in semi-arid climates. With selection and breeding, yields of 16 Mg ha−1 y−1 may be achieved. Current field observations, with no crop improvement, indicate ~9 Mg ha−1 is the maximum yield, and in arid regions, a yield of ~3 Mg ha−1 y−1 is observed. It may be beneficial to breed for a shorter time to flowering, as has been successful for Agave tequilana Weber var. azul, so that further breeding goals are achievable in a decadal timespan. Specific trait selection during breeding will depend on whether fiber or sugar yields are the desired products at a given location. Even without breeding, varieties of Agave americana are climate resilient alternatives for some current commodity crops.
Almost everywhere convergence of ergodic series

We consider ergodic series of the form $\sum _{n=0}^{\infty }a_{n}f(T^{n}x)$ , where $f$ is an integrable function with zero mean value with respect to a $T$ -invariant measure $\unicode[STIX]{x1D707}$ . Under certain conditions on the dynamical system $T$ , the invariant measure $\unicode[STIX]{x1D707}$ and the function $f$ , we prove that the series converges $\unicode[STIX]{x1D707}$ -almost everywhere if and only if $\sum _{n=0}^{\infty }|a_{n}|^{2}<\infty$ , and that in this case the sum of the convergent series is exponentially integrable and satisfies a Khintchine-type inequality. We also prove that the system $\{f\circ T^{n}\}$ is a Riesz system if and only if the spectral measure of $f$ is absolutely continuous with respect to the Lebesgue measure and the Radon–Nikodym derivative is bounded from above as well as from below by a constant. We check the conditions for Gibbs measures $\unicode[STIX]{x1D707}$ relative to hyperbolic dynamics $T$ and for Hölder functions $f$ . An application is given to the study of differentiability of the Weierstrass-type functions $\sum _{n=0}^{\infty }a_{n}f(3^{n}x)$ .