Miracle-dz/UniFAR-FTUs huggingface dataset:
HIV_A_287201 157..170

1School of Health and Human Performance, Dalhousie University, Halifax, NS, Canada; 2Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; 3Department of Medicine, St. Michael’s Hospital, Toronto, ON, Canada Introduction: Pre-exposure prophylaxis (PrEP) is an effective HIV prevention tool that requires the ongoing support of physicians to be accessible. Recently, Nova Scotia experienced a 100% increase in HIV diagnoses. The purpose of this study is to explore the relationship between physicians’ support of PrEP, knowledge of PrEP, and PrEP prescribing history using the information-motivation-behavioral (IMB) skills model. Methods: An online survey was distributed to physicians in Nova Scotia, Canada, and eighty physicians participated. Two exploratory factor analyses were conducted with items from the Support of PrEP scale and Knowledge of PrEP scale. A mediation analysis was conducted to assess if knowledge of PrEP mediated the relationship between support of PrEP and whether physicians have prescribed PrEP in the past. Results: On average, physicians reported strong support for PrEP, and as support for PrEP increased so did knowledge of PrEP. Further, physicians who had prescribed PrEP demonstrated strong knowledge of PrEP and physicians who had not prescribed PrEP reported feeling neutral. The 95% bootstrap confidence interval indirect effect of Support for PrEP on prescription history did not include zero (B = 1.59, 95% BsCI [0.83, 3.57]) demonstrating that the effect of support for PrEP is mediated by knowledge of PrEP. The most commonly identified barrier to prescribing PrEP was the lack of drug coverage among patients. Conclusion: The results of the mediation analysis support the IMB skills model regarding support for PrEP, Knowledge of PrEP, and having prescribed PrEP in the past. Our findings suggest that to improve PrEP uptake in Nova Scotia, educational interventions for physicians and universal coverage of the drug would be necessary.
Towards Enhanced Location-based Services through Real-time Analysis and Mobility Patterns Acquisition

-This paper presents a work in progress towards a middleware platform to support enhanced location-based services through real-time mobility analysis and mobility patterns acquisition. The platform provides services for mobile users and also for mobility analysts. Mobile users are enabled to receive notifications in response to emergency, contingency situations or deviations from mobility patterns. Mobility analysts are enabled to analyse mobility behaviour of users during time scales and territorial scopes as well as to obtain and program mobility patterns and indicators of mobile users and groups of users. Enhanced location-based services are possibly if and only if powerful and efficient capturing, pre-and post-processing of mobile information schemes are adequately implemented and put in place in favour of ubiquitous location service provisioning.
Research Online Research Online Influence of soil clogging on the performance of jute fibre drains Influence of soil clogging on the performance of jute fibre drains installed in Ballina clay installed in Ballina clay

Abstract Biodegradable prefabricated vertical drains (BPVD) made from naturally occurring materials such as jute and coconut (coir) fibre not only have favourable engineering characteristics but also not detri-mental to the natural environment thanks to their biodegradability. Although the use of these natural fibre drains has been proposed for several decades, their application is still very limited. One of major reasons for this is because they are usually composed of individual fibres with large openings which can trap fine soils while discharging pore pressure, consequently reducing the hydraulic conductivity of the drain. This study therefore aims to clarify how soil can clog and damage the porous nature and hydraulic properties of fibre drains through an experimental scheme. A typical natural fibre drain composed of a jute sheath and coconut core was adopted in this investigation. A series of discharge capacity tests, in which the drain was confined by soft clay, were conducted. The drain was then subjected to a post-analysis process using micro-CT scanning to identify how the fine soil has penetrated into the drain and whether this has degraded the discharge capacity of the drain. The results indicate that the current drains can resist well soil clogging due to an initial confining pressure of 50 kPa but the drain discharge capacity can decrease considerably if a higher initial confining pressure, i.e., 100 kPa, is applied. ABSTRACT: Biodegradable prefabricated vertical drains (BPVD) made from naturally occurring materials such as jute and coconut (coir) fibre not only have favourable engineering characteristics but also not detri-mental to the natural environment thanks to their biodegradability. Although the use of these natural fibre drains has been proposed for several decades, their application is still very limited. One of major reasons for this is because they are usually composed of individual fibres with large openings which can trap fine soils while discharging pore pressure, consequently reducing the hydraulic conductivity of the drain. This study therefore aims to clarify how soil can clog and damage the porous nature and hydraulic properties of fibre drains through an experimental scheme. A typical natural fibre drain composed of a jute sheath and coconut core was adopted in this investigation. A series of discharge capacity tests, in which the drain was confined by soft clay, were conducted. The drain was then subjected to a post-analysis process using micro-CT scanning to identify how the fine soil has penetrated into the drain and whether this has degraded the discharge capacity of the drain. The results indicate that the current drains can resist well soil clogging due to an initial confining pressure of 50 kPa but the drain discharge capacity can decrease considerably if a higher initial confining pressure, i.e., 100 kPa, is applied.
A Cancer Patient Journey: 360 Degree Review during Acute Treatment Phase

Cancer is a chronic illness with acute episodes lasting for years. Most cancer patients have coexisting comorbidities, which affect cancer treatment outcomes and make a shared care model for chronic diseases essential. There is a considerable gap between the achievable and delivered quality of care for cancer patients. We used a case study approach to examine the complexity of cancer management, from the perspective of one person’s case as interpreted by the care team. It allowed the complexity of cancer management to retain its holistic and meaningful characteristics. We interviewed the patient, caregiver, Primary Care Physician (PCP), oncologist and oncology nurse. Interviews were audio recorded and analyzed with ATLA Sti, qualitative statistical software. Participants also completed a basic demographic survey. Common themes were identified, analyzed and discussed. Results identify three main themes: lack of longitudinal relationship with PCP, communication barriers, and ambiguous health care provider roles. Communication barriers can be associated with the other two main themes. Our results show that shared care for cancer management is lacking during the acute cancer treatment phase. Communication barriers between the PCP and oncologist along with lack of continuity of care and unclear role of the PCP are major contributors for fragmented cancer care.
State Ownership and Firm Performance: A Performance Evaluation of Disinvested Public sector Enterprises

I. Chhabraa , s. Guptab, V. K. Guptac a, b Amity University, Noida, India; c Indian Institute of Management, Indore, Madhya Pradesh, India a https://orcid.org/0000-0003-1029-8771; b https://orcid.org/0000-0001-9862-5612; c https://orcid.org/0000-0001-6557-1697  Corresponding author AbsTRACT The Indian government devised a flexible method to modify the performance of public sector firms through disinvestment in the 1990s to boost commercial strength and bridge the budget deficit. The disinvestment policy intends to reduce the government’s involvement in the country’s economic activities to encourage the private sector. The research aims to empirically examine the financial and operating performance of thirty-two Central public sector enterprises (CPSEs) in India. Further, the paper intends to study the other firm factors that influence the performance parameters. The Wilcoxon signed-rank test and random panel regression model are the methods employed to analyze the data statistically. The results show that the profitability of disinvestment has not brought significantly much improvement post-privatization in PSEs. In contrast, the productivity of employees has improved. Dividend payout ratio and no. of employees have shown improvement after five years of disinvestment, and leverage has insignificantly declined. In addition, state ownership shows a significant negative relationship with the performance variables. It implies that higher the equity shareholding of the government (state ownership) in the CPSEs, would negatively hamper the performance of firms. On the other hand, GDP and firm size are positively affecting the profitability and productivity of employees. The study concludes that the government is required to bring down the equity shareholdings in CPSEs, directing more efforts towards strategic disinvestment. Government should choose strategic disinvestment rather than partial and small-scale disinvestment because neither will offer good results. The decline in leverage shows the availability of cheaper sources of finance. Furthermore, it has been suggested that government interference in operational and administrative functions should be given the least priority.
VHRM_A_251927 249..256

1Division of Immunology and Allergy, Department of Pediatrics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 2Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 3Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 4Department of Endocrinology and Metabolism, Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 5Department of Statistics and Epidemiology, Faculty of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 6Department of Medical Genetics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Background: The role of metabolic states in cardiovascular risks among individuals with varying degrees of obesity is unknown. The study aimed to compare cardiometabolic index (CMI), atherogenic index of plasma (AIP), lipid accumulation product (LAP) and novel anthropometric indices in metabolic and non-metabolically obese individual with regard to the role of FTO gene in Iranian adults. Methods: In total, 165 individuals were recruited into this cross-sectional study. Individuals grouped into four groups: metabolic healthy normal-weight (MHNW) individuals, metabolically unhealthy normal-weight (MUNW) individuals, metabolically healthy obese (MHO) individuals and metabolic unhealthy obese (MUO) individuals. The dietary intake was evaluated by food frequency questionnaire (FFQ). The cardiovascular indices (CMI, AIP and LAP) were calculated. A variety of anthropometric indices were calculated, including body adiposity Index (BAI), weight-adjusted-waist index (WWI), A body shape index (ABSI) and waist-height ratio (WHR). The genotypes of FTO-rs9939609 subjects were detected by the polymerase chain reaction-restriction fragment length polymorphism (PCRRFLP). Results: The individuals with metabolically unhealthy phenotypes (MUO, MUNW) have higher levels of triglyceride and cardiovascular indices (AIP, LAP and CMI) than the individuals with metabolic healthy phenotypes (MHO, MHNW). With a similar degree of obesity, the anthropometric indices (BAI, WWI and WHR) levels were higher in metabolic unhealthy groups than metabolically healthy groups. The highest frequency of obesity-risk allele AA of FTO gene was observed in MUO, MHO, MUNW and MHNW, respectively. Conclusion: Normal-weight individuals with metabolic unhealthy status are at higher risk for cardiovascular diseases than obese individuals with metabolically healthy status. The genotype frequencies of obesity-risk allele AA of FTO gene were higher in obesity phenotypes than metabolic phenotypes.
Negative Transcription Factor That Binds to the Upstream Conserved Region of Moloney Murine Leukemia Virus

as UCRBP, that binds specifically to the UCR core sequence. Gel mobility shift assays demonstrate that the UCRBP fusion protein expressed in bacteria binds the UCR core with specificity identical to that of the UCR-binding factor in the nucleus of murine and human cells. Analysis of full-length UCRBP cDNA reveals that it has a putative zinc finger domain composed of four C2H2 zinc fingers of the GLI subgroup and an N-terminal region containing alternating charges, including a stretch of 12 histidine residues. The 2.4-kb UCRBP message is expressed in all cell lines examined (teratocarcinoma, Band T-cell, macrophage, fibroblast, and myocyte), consistent with the ubiquitous expression of the UCR-binding factor. Transient transfection of an expressible UCRBP cDNA into fibroblasts results in down-regulation of MuLV promoter activity,
A Phase 1b/2 Study of Pepinemab in Combination with Avelumab in Advanced Non-Small Cell Lung Cancer

Michael Rahman Shafique, Terrence Lee Fisher, Elizabeth E. Evans, John E. Leonard, Desa Rae Electa Pastore, Crystal L. Mallow, Ernest Smith, Vikas Mishra, Andreas Schröder, Kevin M. Chin, Joseph Thaddeus Beck, Megan Ann Baumgart, Ramaswamy Govindan, Nashat Y. Gabrail, Alexander I. Spira, Nagashree Seetharamu, Yanyan Lou, Aaron Scott Mansfield, Rachel E. Sanborn, Jonathan W Goldman, Maurice Zauderer
ON INFORMATION FUNCTIONS PART TWO: APPLICATIONS TO THE LOGIC OF THEORY CHANGE

The purpose of this work is to show how the notion of informationfunction introduced in [1] can be used in the logic of theory change devel-oped by P. G¨ardenfors, C. E. Alchourron and D. Makinson in [2], [3] and[4]. The simplest and best known form of theory change is expansion,whereanewposition, ifconsistentwithagiventheoryK, isset-theoreticallyadded to K and this expanded set is then closed under logical consequence.Second form is theory contraction, where a proposition α, which was earlierin a theory K, is rejected. The basic problem is to determine which propo-sitions should be rejected along with α so that the contracted theory will beclosed under logical consequence. Third kind of change is revision, wherea proposition, in general inconsistent with a given theory K, is added toK under the requirement that the revised theory be consistent and closedunder logical consequence.In this note we shall focus on the contraction functions, i.e. functionswhich reﬂect the process of contraction according to G¨ardenfors postulates(see deﬁnition B.1.). We will point how using the notions presented in PartOne can be proved a few important theorems about contraction functions(in the less general case than in [2] and [3], where C is not necessarily theclassical consequence). Our leading idea is rather intuitive. Loosely speaking, a proposition αis rejected from a theory K if at least a part of information contained in αhas lost its credibility and the contraction operation is to reject, along withα, those formulas which contain any component of “bad” information.
Creative Experiments Using a System for Learning High-Level Performance Structure in Ableton Live

The Agent Design Toolkit is a software suite that we have developed for designing the behaviour of musical agents; software elements that automate some aspect of musical composition or performance. It is intended to be accessible to musicians who have no expertise in computer programming or algorithms. However, the machine learning algorithms that we use require the musician to engage with technical aspects of the agent design, and our research goal is to ﬁnd ways to enable this process through understandable and intuitive concepts and interfaces, at the same time as developing effective agent algorithms. Central to enabling musicians to use the software is to make available a set of clear instructional examples showing how the technical aspects of agent design can be used effectively to achieve particular musical results. In this paper, we present a pilot study of the Agent Design Toolkit in which we conducted two contrasting musical agent design experiments with the aim of establishing a set of such examples. From the results, we compiled a set of four clear examples of effective use of the learning parameters which will be used to teach new users about the software. In addition, we identiﬁed a range of improvements which can be made to the software itself.
COPD_A_194991 881..892

1Pulmonary Section, Minneapolis Veterans Affairs Health Care System, Minneapolis, MN, USA; 2Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA; 3TMD, Orofacial Pain, and Dental Sleep Medicine, University of Minnesota, Minneapolis, MN, USA; 4Dental Section, Minneapolis Veterans Affairs Health Care System, Minneapolis, MN, USA; 5Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA; 6Infectious Disease Section, Minneapolis Veterans Affairs Health Care System, Minneapolis, MN, USA; 7Division of Infectious Disease, Department of Medicine, University of Minnesota, Minneapolis, MN, USA Introduction: Poor oral health has been implicated as an independent risk factor for the development of COPD, but few studies have evaluated the association between oral health and COPD exacerbations. We aimed to determine if poor oral health is associated with COPD exacerbations and/or worse respiratory health. Methods: We performed a case-control study of oral health among COPD exacerbators and non-exacerbators. Cases (exacerbators) had experienced ≥1 exacerbation in the previous 12 months, while controls (non-exacerbators) had no exacerbations in the previous 24 months. We excluded those with <4 teeth. We evaluated the global oral health assessment, Oral Health Impact Profile (OHIP-5), dental symptoms/habits, and St. George’s Respiratory Questionnaire (SGRQ). In a subset, we performed blinded dental exams to measure bleeding on probing, probing depth, clinical attachment loss, periodontitis severity, plaque index, gingival index, and carries risk. We evaluated associations between oral health and COPD exacerbations using logistic regression. Linear regression was used to assess relationships between oral health and SGRQ scores. Results: Screened non-exacerbators (n=118) were significantly more likely to have <4 teeth, compared to screened exacerbators (n=100) (44% vs 30%, respectively; p=0.046). After excluding those with <4 teeth, there were 70 cases and 66 controls. Self-reported oral health and objective dental exam measures did not vary significantly between cases vs controls. However, the odds of severe COPD exacerbations requiring hospitalizations and/or emergency department visits trended higher in those with worse dental exam compared to those with better dental exam. Worse OHIP-5 was strongly associated with worse SGRQ scores. Conclusions: Oral health status was not related to COPD exacerbations, but was associated with self-reported respiratory health. Non-exacerbators were more likely to be edentate or have ≤4 teeth compared to exacerbators. Larger studies are needed to address oral health as a potential method to improve respiratory health in patients with COPD.
Clinical Outcome of Premature Babies Admitted in the Neonatal Unit of a Tertiary Hospital in Port Harcourt

Background: Prematurity, a significant cause of under-five and neonatal mortality and morbidity is on the increase especially in Africa and Asia and threatens efforts to significantly reduce under-five mortality in middleand low-income countries. Objectives: To determine the prevalence and outcome of premature babies in Rivers State University Teaching Hospital, Port Harcourt. Materials and methods: A one-year prospective study was carried out in the special care baby unit of the Rivers State University Teaching Hospital. A pre tested questionnaire was used to collect data from mothers and babies delivered prematurely from the time of admission to discharge or death. Results: Of 468 neonates admitted into the unit, 217 (46.4%) were preterm babies, majority of whom were delivered at 33-36 weeks (74.7%) and weighed 1.5-2.49kg (57.1%). The commonest pregnancy complications of mothers of premature babies were hypertension in pregnancy (41.7%) and premature rupture of membranes (34.8%), while neonatal jaundice (58.5%), respiratory distress (57.1%) and probable sepsis (55.3%) were common morbidities observed. A total of 191 (88%) of them were discharged home and this outcome was significantly associated with gestational age (GA) of 33-36 weeks, birth weight > 2.5kg, normal APGAR scores, feeds commenced on or after 2 nd day of life, caesarean section delivery and those with temperatures below 36 0 C at presentation, (p < 0.05). Conclusion: The prevalence of prematurity was high. Early identification and management of predisposing factors of preterm deliveries and adequate management of these babies when delivered will reduce the prevalence and improve the outcome of premature babies.
Activation of the High-Affinity Immunoglobulin E Receptor FcεRI in RBL-2H3 Cells Is Inhibited by Syk SH2 Domains

Antigen-mediated aggregation of the high-affinity receptor for immunoglobulin E, Fc«RI, results in the activation of multiple signaling pathways, leading to the release of mediators of the allergic response. One of the earliest responses to receptor stimulation is the tyrosine phosphorylation of the b and g subunits of Fc«RI and the association of the tyrosine kinase Syk with the phosphorylated receptor. This association is mediated by the SH2 domains of Syk and is believed to be critical for activating signaling pathways resulting in mediator release. To examine the importance of the interaction of Syk with Fc«RI in signaling events following receptor activation, we introduced a protein containing the SH2 domains of Syk into streptolysin O-permeabilized RBL-2H3 cells. The Syk SH2 domains completely inhibited degranulation and leukotriene production following receptor aggregation, and they blocked the increase in protein tyrosine phosphorylation observed after receptor activation. Inhibition was specific for Fc«RI-mediated signaling, since degranulation of cells activated by alternative stimuli was not blocked by the Syk SH2 domains. A protein containing a point mutation in the carboxy-terminal SH2 domain which abolishes phosphotyrosine binding was not inhibitory. In addition, inhibition of degranulation was reversed by pretreatment of the SH2 domains with a tyrosine phosphorylated peptide corresponding to the tyrosine-based activation motif found in the g subunit of Fc«RI, the nonphosphorylated peptide had no effect. The association of Syk with the tyrosine-phosphorylated g subunit of the activated receptor was blocked by the Syk SH2 domains, and degranulation in cells activated by clustering of Syk directly without Fc«RI aggregation was not affected by the Syk SH2 domains. These results demonstrate that the association of Syk with the activated Fc«RI is critical for both early and late events following receptor activation and confirm the key role Syk plays in signaling through the high-affinity IgE receptor.