Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Endometrium Thickness on Clinical Outcomes in Luteal Phase Short-Acting GnRH-a Long Protocol and GnRH-Ant Protocol

Objective To investigate the factors that influence luteal phase short-acting gonadotropin-releasing hormone agonist (GnRH-a) long protocol and GnRH-antagonist (GnRH-ant) protocol on pregnancy outcome and quantify the influence. About the statistical analysis, it is not correct for the number of gravidities. Methods Infertile patients (n = 4,631) with fresh in-vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) and embryo transfer were divided into GnRH-a long protocol (n =3,104) and GnRH-ant (n =1,527) protocol groups and subgroups G1 (EMT ≤7mm), G2 (7 mm 10 mm) according to EMT on the trigger day. The data were analyzed. Results The GnRH-ant and the GnRH-a long protocols had comparable clinical outcomes in the clinical pregnancy, live birth, and miscarriage rate after propensity score matching. In the medium endometrial thickness of 7–10 mm, the clinical pregnancy rate (61.81 vs 55.58%, P < 0.05) and miscarriage rate (19.43 vs 12.83%, P < 0.05) of the GnRH-ant regime were significantly higher than those of the GnRH-a regime. The EMT threshold for clinical pregnancy rate in the GnRH-ant group was 12 mm, with the maximal clinical pregnancy rate of less than 75% and the maximal live birth rate of 70%. In the GnRH-a long protocol, the optimal range of EMT was >10 mm for the clinical pregnancy rate and >9.5 mm for the live birth rate for favorable clinical outcomes, and the clinical pregnancy and live birth rates increased linearly with increase of EMT. In the GnRH-ant protocol, the EMT thresholds were 9–6 mm for the clinical pregnancy rate and 9.5–15.5 mm for the live birth rate. Conclusions The GnRH-ant protocol has better clinical pregnancy outcomes when the endometrial thickness is in the medium thickness range of 7–10 mm. The optimal threshold interval for better clinical pregnancy outcomes of the GnRH-ant protocol is significantly narrower than that of the GnRH-a protocol. When the endometrial thickness exceeds 12 mm, the clinical pregnancy rate and live birth rate of the GnRH-ant protocol show a significant downward trend, probably indicating some negative effects of GnRH-ant on the endometrial receptivity to cause a decrease of the clinical pregnancy rate and live birth rate if the endometrial thickness exceeds 12 mm.
Direct Patterning of Robust One-Dimensional, Two-Dimensional, and Three-Dimensional Crystalline Metal Oxide Nanostructures Using Imprint Lithography and Nanoparticle Dispersion Inks

Dimensionally stable one-dimensional (1-D), two-dimensional (2-D), and three-dimensional (3-D) high aspect ratio crystalline metal oxide nanostructures are fabricated using soft nanoimprint lithography with inks comprised of nanoparticle (NP) dispersions in solvent or in sol–gel precursors for the metal oxide. Crystalline TiO2 and indium tin oxide (ITO) NP dispersions in solvent are imprinted using a solvent permeable patterned poly(dimethylsiloxane) (PDMS) stamp to yield robust crystalline nanostructures that are dimensionally stable to calcination (less than 8% linear shrinkage in imprinted feature heights upon heat treatment at 500 °C). Inks comprised of 80% crystalline NPs dispersed in 20% sol–gel binder are patterned using thermal- or UV-assisted imprinting with a PDMS stamp. The composition and physical properties of the dimensionally stable imprinted metal oxides (TiO2 and ITO) can be altered by varying the composition of the ink. Rapid printing of high aspect ratio nanostructures and sub-100 nm fe.
Moose Habitat Selection and Fitness Consequences During Two Critical Winter Tick Life Stages in Vermont, United States†

The moose (Alces alces) is a charismatic species in decline across much of their southern distribution in North America. In the northeastern United States, much of the reduction has been attributed to winter tick (Dermacentor albipictus) infestations. Winter ticks are fairly immobile throughout all life stages, and therefore their distribution patterns at any given time are shaped largely by the occurrence of moose across the landscape during the peak of two critical time periods: fall questing (when ticks latch onto moose) and spring drop-off (when engorged female ticks detach from moose). We used recent land cover and lidar data within a dynamic occupancy modeling framework to estimate first-order habitat selection (use vs. non-use) of female moose (n = 74) during the tick questing and drop-off periods. Patch extinction and colonization rates between the fall questing and spring drop-off periods were strongly influenced by habitat and elevation, but these effects were diminished during the fall questing period when moose were more active across the landscape. From the fall questing period to the spring drop-off period, patches where colonization was high and extinction was low had higher proportions of young (shrub/forage) mixed forest at higher elevations. Further, we evaluated the fitness consequences of habitat selection by adult females during the fall questing period, when females and their calves acquire ticks. We compared Resource Selection Functions (RSF) for five females that successfully reared a calf to age 1 with five females whose calves perished due to ticks. Adult female moose whose offspring perished selected habitats in the fall that spatially coincided with areas of high occupancy probability during the spring tick drop-off period. In contrast, adult female moose whose offspring survived selected areas where the probability of occupancy during the spring drop-off was low; at present, natural selection may favor female adults who do not select the same habitats in fall as in spring. Our model coefficients and mapped results define “hotspots” that are likely encouraging the deleterious effects of the tick-moose cycle. These findings fill knowledge gaps about moose habitat selection that may improve the effectiveness of management aimed at reversing declining population trends.
Immunometabolism at the Nexus of Cancer Therapeutic Efficacy and Resistance

Constitutive activity of the immune surveillance system detects and kills cancerous cells, although many cancers have developed strategies to avoid detection and to resist their destruction. Cancer immunotherapy entails the manipulation of components of the endogenous immune system as targeted approaches to control and destroy cancer cells. Since one of the major limitations for the antitumor activity of immune cells is the immunosuppressive tumor microenvironment (TME), boosting the immune system to overcome the inhibition provided by the TME is a critical component of oncotherapeutics. In this article, we discuss the main effects of the TME on the metabolism and function of immune cells, and review emerging strategies to potentiate immune cell metabolism to promote antitumor effects either as monotherapeutics or in combination with conventional chemotherapy to optimize cancer management.
Comparing the Effect of a Herbal-based Laxative (Goleghand®) and Polyethylene Glycol on Functional Constipation among Children: A Randomized Controlled Trial

Objective: This study aimed to evaluate the effectiveness, safety, and document the reported adverse effect of a herbal-based laxative (Goleghand®) for the maintenance treatment of functional constipation in young children. Methods: We conducted a randomized clinical trial from April 2019 to September 2020. Children aged 2–15 years with functional constipation defined according to the Rome IV criteria were eligible for study inclusion. Eligible children were randomly allocated to receive polyethylene glycol (PEG) or Goleghand®. The number and consistency of stools per day, painful defecation, abdominal pain, and fecal incontinence were reported weekly by parents. The statistical analyses were performed by determining means and standard deviations, t-test, Chi-square test, ANOVA repeated measures, and Fisher's exact test, with significance, accepted at the 5% level. Findings: Sixty patients have been enrolled in the study. Parental satisfaction scores did not change significantly in either group or over the follow-up period. Our results showed that the effect of time (P < 0.001) and also the effect of group type (P = 0.01) on the number of fecal defecations was significant. The mean number of defecations increased first and then decreased significantly over time, but this decrease was more significant in the PEG group than in the Goleghand® group (P = 0.001). Furthermore, the effect of time on the fecal consistency score was significant (P = 0.047). The mean score of fecal consistency in both groups decreased over time. Conclusion: Goleghand® was similar in efficacy to PEG for 8 weeks of pediatric functional constipation treatment in this randomized clinical trial. Goleghand® can be considered as a new herbal laxative drug for pediatric functional constipation.
Solitary plasmacytoma of jaw bone: A case report and systematic review of fifty cases from literature

Solitary plasmacytoma of bone (SPB) is a localized form of plasma cell neoplasm where jaw involvement is rare. Distinguishing SPB from other plasma cell neoplasms is critical for treatment and survival. Here, a case of SPB of mandible in an elderly female is reported. Histopathological diagnosis of plasma cell neoplasm was confirmed immunohistochemically with MUM1 and CD138 positivity and multiple myeloma (MM) was ruled out on performing systemic workup. Prognosis of SPB worsens when it transforms into MM. A systematic review was undertaken with the objective to determine the factors affecting conversion of SPB to MM. An electronic search was undertaken with PubMed/MEDLINE, Web of Science and Science Direct. Fifty cases of SPB of jaw from 29 publications were reviewed. SPB commonly presents as a painless swelling. Radiographically, it is commonly seen as multilocular radiolucency with well-defined borders. Follow-up data showed that nine cases turned into MM in a mean duration of 1 year 9 months and 12 patients died after median disease-free survival of 6 years 9 months. Prognosis of SPB is found to be affected by tumor size (≥5 cm), anaplasia of tumor cells, Ki-67 labeling index, vascularity of the tumor, presence of clonal bone marrow plasma cells, serum immune globulin level, dose of radiotherapy and persistence of M protein after treatment. There is a need to identify prognostic subgroups in SPB based on these factors. Furthermore, studies are necessary for standardization of treatment protocol to halt or prolong the progression of SPB to MM.
Atmospheric Measurements of Biogenic and Anthropogenic Emissions by Broadband Cavity Enhanced Absorption Spectroscopy

This thesis describes the quantification of biogenic and anthropogenic trace gases using the highly sensitive spectroscopic technique of broadband cavity enhanced absorption spectroscopy (BBCEAS). This technique uses a high finesse optical cavity to make absorption measurements over extended path lengths within a compact instrument and over wavelength ranges that are sufficiently broad to enable several overlapping absorbers to be quantified simultaneously. Here, BBCEAS was applied to measure I2 emissions in coastal regions, NO2 in urban ambient air, and VOC oxidation products during experiments in an atmospheric simulation chamber. Much of the work used a novel, mobile, battery-powered BBCEAS system to measure gas concentrations in very close proximity to their emission sources. The dominant emission source of iodine into the atmosphere in coastal regions comes from intertidal macroalgal beds. Gas-phase iodine chemistry perturbs the HOx and NOx radical cycles, provides additional sink reactions for tropospheric ozone, and initiates nucleation of new aerosol particles. Results are presented from an extensive laboratory study of I2 emissions from five species of temperate seaweeds. Timeand speciesdependent I2 emission rates were quantified in studies mimicking the progressive exposure of seaweeds to air around low tide. Seasonal differences in I2 emission rates were investigated. By deploying the BBCEAS instrument from a boat, I2 concentrations were also measured directly above Laminaria digitata and Ascophyllum nodosum seaweeds growing in their natural habitat. NOx emissions affect urban air quality directly and indirectly (the latter via formation of tropospheric ozone and secondary aerosol). BBCEAS was applied to measure NO2 and the optical extinction from aerosol particles at locations around the Leicester University campus. BBCEAS results were compared with commercial NOx (chemiluminescence) and aerosol instrumentation. The mobile BBCEAS instrument was also deployed to investigate the dispersion of NO2 from the roadside.
Hybrid Equity Warrants Pricing Formulation under Stochastic Dynamics

Abstract—A warrant is a financial contract that confers the right but not the obligation, to buy or sell a security at a certain price before expiration. The standard procedure to value equity warrants using call option pricing models such as the Black–Scholes model had been proven to contain many flaws, such as the assumption of constant interest rate and constant volatility. In fact, existing alternative models were found focusing more on demonstrating techniques for pricing, rather than empirical testing. Therefore, a mathematical model for pricing and analyzing equity warrants which comprises stochastic interest rate and stochastic volatility is essential to incorporate the dynamic relationships between the identified variables and illustrate the real market. Here, the aim is to develop dynamic pricing formulations for hybrid equity warrants by incorporating stochastic interest rates from the Cox-Ingersoll-Ross (CIR) model, along with stochastic volatility from the Heston model. The development of the model involves the derivations of stochastic differential equations that govern the model dynamics. The resulting equations which involve Cauchy problem and heat equations are then solved using partial differential equation approaches. The analytical pricing formulas obtained in this study comply with the form of analytical expressions embedded in the Black-Scholes model and other existing pricing models for equity warrants. This facilitates the practicality of this proposed formula for comparison purposes and further empirical study.
Vadimus : 1 Inclusion of ecological , economic , social and institutional considerations 2 when setting targets and limits for multispecies fisheries 3

43 Targets and limits for long-term management are used in fisheries advice to operationalize 44 the way management reflects societal priorities on ecological, economic, social and institutional 45 aspects. This study reflects on the available published literature as well as new research presented at 46 the international ICES/Myfish symposium on targets and limits for long term fisheries management. 47 We examine the inclusion of ecological, economic, social and institutional objectives in fisheries 48 management, with the aim of progressing towards including all four objectives when setting 49 management targets or limits, or both, for multispecies fisheries. The topics covered include 50 ecological, economic, social and governance objectives in fisheries management, consistent 51 approaches to management, uncertainty and variability, and fisheries governance. We end by 52 identifying ten ways to more effectively include multiple objectives in setting targets and limits in 53 ecosystem based fisheries management. 54
THE ROLE OF GOVERNMENT AND AUDITING OFFICES IN ACTIVATING THE FORENSIC ACCOUNTING TO DISCOVER FINANCIAL FRAUD

The objective of this research is to investigate the role of auditing offices and governmental efforts to activate forensic accounting as a tool to fighting financial crime. The questionnaire was used to collect data. The response subjects were the employees of auditing offices. The results showed that the auditing offices care for teaching of their experience inside the offices. The respondents indicated the importance role of governmental bodies to activate forensic accounting role. The study recommended the establishment of national fraud board to regulated the national plans to activate the forensic accounting and fighting fraud.
Decentralized Collision Free Velocities from Depth Maps using Deep Reinforcement Learning

Producing an optimal path for robots in a multi-agent scenario is challenging when the environment is only partially observable. Current solutions to this problem often work by assuming near-perfect knowledge of their neighbor’s states. This work presents a solution to this problem based only on a point cloud reading of the environment in front of the scenario, current velocity, and goal position.
Portal Receivers ' expectations for abstract versus concrete construals : Evidence for conversational relevance as a determinant of construal level

why version: answers the question “Why are you going on vacation? ” I feel like a long vacation, somewhere far away. I love to travel. Mexico has places where I can relax and also see some amazing natural landscapes. That’s why I choose Mexico as the destination. There are great beaches and many important cultural sites Clark, Semin / Conversational Relevance 165
Automated detection of hepatic vascular bifurcations in ultrasound volumes

Surgical navigation aims to improve liver lesion localization by showing the preoperative liver-tumor model together with the intraoperative surgical instruments. This is most often achieved through a landmark-based registration process, where vascular bifurcations between preoperative and intraoperative imaging are identified by the surgeon and matched. The vascular bifurcations are intraoperatively identified using a tracked ultrasound (US). This results in added surgical time and user dependence. Our method comprises a 3D U-Net implementation to automatically detect vascular bifurcations in intraoperative US volumes for registration with their preoperative counterparts. Experiments are conducted on 33 scans containing 950 bifurcations. Based on a hit-or-miss criterion with different label radius sizes (1 to 5 mm), the model shows an F1-score ranging from 40% to 56%, and a fiducial localization error ranging from 1.7 to 2.6 mm. In conclusion, vascular bifurcations detection in US volumes can be automated using a 3D U-Net.
Advances in hybrid wheat seed production system

In hybrid seed production especially in self-pollinating crops, key role is played by precise control over pollen fertility. A number of techniques such as emasculation, male sterility, XYZ system and biotechnological approaches for pollen abortion have been proposed to prevent autogamy in female parental lines of wheat to facilitate hybrid seed production. However, use of these techniques are limited by restricted outcrossing behavior of wheat crop which can be improved by redesigning the floral architecture. In development of hybrid wheat, the novel approach of split gene system and redesigning the floral architecture could be a potent alternative. This manuscript provides an explicit information on the various techniques used in hybrid seed production in wheat and hopefully be a valuable resource in guiding future hybrid breeding programmes in wheat.
Selecting Coastal California Prairie Species for Climate-Smart Grassland Restoration

California is predicted to experience warmer temperatures and more frequent droughts in future years, which will increase local and regional climatic water deficit. Understanding how commonly used restoration species will respond to drought may help with approaches to mediate the negative impacts of changing climates on restoration. Associated plant functional traits can increase understanding of how a group of species responds to variable environmental conditions, and aid with selecting broader mixes of drought-tolerant plants for restoration. For this study, we established ambient rainfall, first-year watered and drought treatments (60% rainfall reduction), in a coastal grassland in Santa Cruz, CA. Drought was created using rain-out shelters that simulate a 1-in-100-year drought. We planted 12 California native coastal prairie species to determine which species and life-forms had greater survivorship. We monitored the survival of these plantings annually from 2016 to 2019 and assessed the plant community composition in 2018 and 2019. We found that rhizomatous forbs were ideal candidates for planting coastal prairie restoration sites, especially in terms of drought. Bunchgrasses were also successful in the drought treatment, but to a lesser degree. Nfixers and non-rhizomatous forbs had minimal survivorship by the fourth year. Our findings demonstrate variable survival of planted seedlings in terms of time and drought. Additionally, from our study, the most favorable candidates for restoring California coastal prairie in a drier climate were common yarrow (Achillea millefolium), prairie mallow (Sidalcea malviflora), and purple needle grass (Stipa pulchra).
Mutation Control in Neat for Customizable Neural Networks

A modification of the NEAT algorithm is proposed through the use of a mechanism for changing the level of mutations. At the same time, both the weight coefficients and the number of neurons in the hidden layers and the connections between them change. For the task of modelling the XOR operator, a significant acceleration of the training of a neural network was obtained.
E � cient Video-Based Deep Learning for Ultrasound Guided Needle Insertion

We investigate video-based deep learning approaches for detecting needle insertions in ultrasound videos. We introduce two e � cient and conceptually simple extensions to convert standard 2D object detectors into video object detectors that encode spatiotemporal information from a history of frames. We demonstrate that learned temporal encoding improves needle detection over spatial encoding alone, particularly for challenging cases. Finally, we show that the proposed methods allow real-time inference on low-cost computing hardware
Rac GTPase activating protein 1 promotes gallbladder cancer via binding DNA ligase 3 to reduce apoptosis

Rac GTPase activating protein 1 (RACGAP1) has been characterized in the pathogenesis and progression of several malignancies, however, little is known regarding its role in the development of gallbladder cancer (GBC). This investigation seeks to describe the role of RACGAP1 and its associated molecular mechanisms in GBC. It was found that RACGAP1 was highly expressed in human GBC tissues, which was associated to poorer overall survival (OS). Gene knockdown of RACGAP1 hindered tumor cell proliferation and survival both in vitro and in vivo. We further identified that RACGAP1 was involved in DNA repair through its binding with DNA ligase 3 (LIG3), a crucial component of the alternative-non-homologous end joining (Alt-NHEJ) pathway. RACGAP1 regulated LIG3 expression independent of RhoA activity. RACGAP1 knockdown resulted in LIG3-dependent repair dysfunction, accumulated DNA damage and Poly(ADP-ribosyl) modification (PARylation) enhancement, leading to increased apoptosis and suppressed cell growth. We conclude that RACGAP1 exerts a tumor-promoting role via binding LIG3 to reduce apoptosis and facilitate cell growth in GBC, pointing to RACGAP1 as a potential therapeutic target for GBC.