Miracle-dz/UniFAR-FTUs huggingface dataset:
The Future of Abdominal Aortic Aneurysm Treatment and the Role of Totally Percutaneous Endografting

cases were reported, with a cumulative two-year survival rate of 85%. 4 In this cohort of patients the 30-day mortality rate was low at 3%, but at discharge 14% of patients presented with an endoleak. In 18%, a new endoleak was reported during the first year of follow-up, and in 22% a continued expansion of the aneurysm was observed. Since the motivation for aneurysm treatment is the elimination of the risk of rupture and death or else to prolong life, new standards for defining abdominal aortic aneurysm (AAA) treatment success have been set over the years. The first set of reporting standards for studies directed at the endovascular repair of the infrarenal aortic aneurysm was introduced by the Ad Hoc Committee for Standardized Reporting Practices in Vascular Surgery of the Society for Vascular Surgery/International Society for Cardiovascular Surgery in 1997. 5 In Abstract Endovascular abdominal aortic aneurysm repair (EVAR) has experienced a continuous spread worldwide as a result of the constant drive to develop innovative methods and devices that enable physicians to achieve therapeutic aims while reducing procedural risks and patient discomfort. Randomised controlled studies have demonstrated clear early benefits over open repair in terms of mortality and morbidity, but a high reintervention rate jeopardised the EVAR outcome. Complications in EVAR, such as endoleaks, separation of modular components, stent or hook fractures and distal migration of the endograft, can lead to aneurysm enlargement and thus to the native risk of aneurysm rupture. In order to prevent such complications and minimise potential re-interventions, new-generation stent grafts, low-profile delivery systems and new percutaneous closing devices have been developed and adopted, making a totally percutaneous approach possible and desirable. Nevertheless, operators must be aware and trained to face every complication that could possibly develop during and after the procedure. Given these circumstances, EVAR is under consideration as the first line of treatment for abdominal aortic aneurysms.
Predicting How People Play Games: Reinforcement Learning in Experimental Games with Unique, Mixed Strategy Equilibria

The authors examine learning in all experiments they could locate involving one hundred periods or more of games with a unique equilibrium in mixed strategies, and in a new experiment. They study both the ex post ('best fit') descriptive power of learning models, and their ex ante predictive power, by simulating each experiment using parameters estimated from the other experiments. Even a one-parameter reinforcement learning model robustly outperforms the equilibrium predictions. Predictive power is improved by adding 'forgetting' and 'experimentation,' or by allowing greater rationality as in probabilistic fictitious play. Implications for developing a low-rationality, cognitive game theory are discussed. Copyright 1998 by American Economic Association.
Examining the influence of co-curricular activities on learner attitudes and achievement in physical sciences

5 ACRONYMS USED IN THE STUDY . 7 List of tables . 15 Table 1: Physical Sciences NSC results for the period 2012 to 2015 18 . 15 Table 2: Sample for the research 57 . 15 Table 3: METHODOLOGICAL FRAMEWORK 59 . 15 Table 4: Learners’ responses to the Pre ATQ 71 . 15 Table 5: Learners’ responses to the Post ATQ 80 . 15 Table 6: Sample of data triangulation table 114 . 15 List of figures . 15 Figure 1: Question-by-question analysis of the 2014 physical science NSC examination 19 Error! Bookmark not defined. Figure 2: graph of learner’s responses to interests in Physical Sciences category of the ATQ Error! Bookmark not defined. Error! Bookmark not defined. Figure 3: Perceptions about Physical Sciences 73 . Error! Bookmark not defined. Figure 4: Use of scientific language 75 . Error! Bookmark not defined. Figure 5: interest of learners towards science after participating in Min Quiz 77 . Error! Bookmark not defined. Figure 6: Use of scientific language after essay writing 78 . Error! Bookmark not defined. Figure 7: interest in Physical Sciences after participating in Expo 82 . Error! Bookmark not defined.
Attenuation Artifacts in SPECT: Effect of Wrap-Around Lung in 180° Cardiac Studies

We estimated that in 75%–90% of PET 82Rb patients the left lung appeared to wrap around the anterior aspect of the left ventricle. We used clinical PET 82Rb myocardial perfusion studies as the input to a SPECT computer simulation model to determine if patients with left lung wrap-around displayed consistent artifacts in reconstructed SPECT images. In particular, we sought an explanation for the hot lateral wall seen in SPECT images from normal female and male patients. Methods: Attenuated SPECT 201TI emission data were simulated from a mid-ventricular slice in 10 randomly selected clinical PET 82Rb studies with left lung wrap-around. In these same cases, the influence of left lung wrap-around was removed by assigning the left lung an attenuation coefficient which matched that of the heart. Five randomly selected clinical PET 82Rb studies without left lung wrap-around were also processed with our model. Results: In all 10 cases with left lung wrap-around, reconstructed SPECT images showed the hot lateral wall artifact with a mean septal-to-lateral wall count ratio of 0.86. With left lung wrap-around removed in the same 10 patients, reconstructed images did not show hot lateral wall (mean septal-to-lateral wall count ratio = 1.07). The 5 cases without left lung wrap-around did not show hot lateral wall (mean septal-to-lateral wall count ratio = 1.04) and the ratios changed little with the filling of the left lung (mean septal-to-lateral wall count ratio = 1.05). Conclusion: Results of our PET-to-SPECT computer simulation model showed that the hot lateral wall artifact found in SPECT myocardial perfusion images was related to the orientation and positions of the left ventricle and the left lung.
Cross-national validity of a spherical conceptual model for parent behavior.

An adapted and translated version of the Child's Report of Parent Behavior Inventory was administered to 182 Walloon high school students. A factor analysis of the intercorrelations of the 18 scales revealed three factors-Acceptance versus Rejection, Psychological Control, and Lax Control versus Firm Control-that were similar for boys and girls, for reports of mothers and fathers, and for American and Walloon subjects. A map of a nomological network of parent-behavior concepts was generated by stereographic projections of each scale's factor loadings. The findings provide evidence of the cross-national validity of a spherical conceptual model for parent behavior.
Fathers and infants : a study of father caregiving and interaction.

Fathers and Infants: A Study of Father Caregiving and Interaction (September 1979) Beverly Schwartz Katsh B • A . , New York University, M . Ed . , Smith College, Ed . D . , University of Massachusetts Directed by: Dr. Mary R. Quilling A great deal of the literature in child development has been devoted to the influence of early family life experience on growth and development. Particular attention has been paid to the influence of the mother and to the impact of the mother-infant and mother-child relationships. By comparison, the father's role in the life of his child has been neglected in the empirical and theoretical literature, particularly in evaluating the father's involvement in physical care and non-care activities with an infant. The purpose of the present study was to assess how fathers involve themselves with their first infants, what factors influence the type of care he provides, and how these interactions change from the neonatal to the postneonatal time. The sample of subjects consisted of 169 couples having their first child. The design of the study was a pretest-posttest two
AUDITORIA INDEPENDENTE E A QUALIDADE DA INFORMAÇÃO NA DIVULGAÇÃO DAS DEMONSTRAÇÕES CONTÁBEIS: ESTUDO COMPARATIVO ENTRE EMPRESAS BRASILEIRAS AUDITADAS PELAS BIG FOUR E NÃO BIG FOUR

A atuacao da auditoria independente ao examinar e opinar sobre as demonstracoes contabeis pode contribuir na contencao de eventuais gerenciamentos de resultados por parte dos gestores, reduzindo ainda a assimetria informacional existente entre gestores e stakeholders e permitindo que as partes interessadas possam verificar a validade da divulgacao. Varios estudos apontam que o tamanho da firma de auditoria reflete em um trabalho de maior qualidade. Por extensao, acredita-se que quanto maior a firma de auditoria menor sera o nivel de Gerenciamento de Resultados (GR) na empresa auditada, dada a sua maior competencia tecnica e grau de independencia. Desta forma, o objetivo do estudo e verificar se os niveis de gerenciamento de resultado se apresentam diferentes para empresas brasileiras auditadas por firmas de auditoria Big Four e nao Big Four . Utilizou-se pesquisa descritiva com abordagem quantitativa. A amostra e composta por 329 empresas de capital aberto listadas na BM&FBovespa segregada em dois grupos: 246 empresas auditadas pelas Big Four e 83 empresas nao auditadas pelas Big Four . Os resultados evidenciaram que a qualidade da informacao contabil nas empresas auditadas pelas Big Four nao apresentaram niveis de GR significativamente diverso das empresas auditadas pelas demais firmas de auditorias.
Statins Directly Regulate Pituitary Cell Function and Exert Antitumor Effects in Pituitary Tumors

Introduction: Pituitary neuroendocrine tumors (PitNETs), the most abundant of all intracranial tumors, entail severe comorbidities. First-line therapy is transsphenoidal surgery, but subsequent pharmacological therapy is often required. Unfortunately, many patients are/become unresponsive to available drugs (somatostatin analogues [SSAs]/dopamine agonists), underscoring the need for new therapies. Statins are well-known drugs commonly prescribed to treat hyperlipidemia/cardiovascular diseases, but can convey additional beneficial effects, including antitumor actions. The direct effects of statins on normal human pituitary or PitNETs are poorly known. Thus, we aimed to explore the direct effects of statins, especially simvastatin, on key functional parameters in normal and tumoral pituitary cells, and to evaluate the combined effects of simvastatin with metformin (MF) or SSAs. Methods: Effects of statins in cell proliferation/viability, hormone secretion, and signaling pathways were evaluated in normal pituitary cells from a primate model (Papio anubis), tumor cells from corticotropinomas, somatotropinomas, nonfunctioning pituitary tumors, and PitNET cell-lines (AtT20/GH3-cells). Results: All statins decreased AtT20-cell proliferation, simvastatin showing stronger effects. Indeed, simvastatin reduced cell viability and/or hormone secretion in all PitNETs subtypes and cell-lines, and ACTH/GH/PRL/FSH/LH secretion (but not expression), in primate cell cultures, by modulating MAPK/PI3K/mTOR pathways and expression of key receptors (GH-releasing hormone-receptor/ghrelin-R/Kiss1-R) regulating pituitary function. Addition of MF or SSAs did not enhance simvastatin antitumor effects. Conclusion: Our data reveal direct antitumor effects of simvastatin on PitNET-cells, paving the way to explore these compounds as a possible tool to treat PitNETs.
Spiro N-methoxy piperidine ring containing aryldiones for the control of sucking pests and mites: Discovery of spiropidion.

BACKGROUND Crop protection solutions for the control of key economic sucking pests derive essentially from neuronal and muscular acting chemistries, wherein neonicotinoid uses largely dominated for the last two decades. Anticipating likely resistance development of some of those arthropod species to this particular class, we intensified research activities on a non-neuronal site of action targeting insect growth and development some 10 years ago. RESULTS Our innovation path featured reactivation of a scarcely used and simple building block from the 1960s, namely N-methoxy-4-piperidone 3. Its judicious incorporation into the 2-aryl-1,3-dione scaffold of IRAC group 23 inhibitors of fatty acid biosynthesis resulted in novel tetramic acid derivatives acting on acetyl-coenzyme A carboxylase (ACCase). The optimization campaign focused on modulation of the aryl substitution pattern and understanding substituent options at the lactam nitrogen position of those spiroheterocyclic pyrrolidine-dione derivatives towards an effective control of sucking insects and mites. This work gratifyingly culminated in the discovery of spiro N-methoxy piperidine containing proinsecticide spiropidion 1. Following in planta release, its insecticidally active dione metabolite 2 is translaminar and two-way systemic (both xylem and phloem mobile) for a full plant protection against arthropod pests. CONCLUSION Owing to such unique plant systemic properties, growing shoots and roots actually not directly exposed to spiropidion-based chemistry after foliar application nevertheless benefit from its long-lasting efficacy. Spiropidion is for use in field crops, speciality crops and vegetables controlling a broad range of sucking pests. In light of other performance and safety profiles of spiropidion, an IPM fit may be expected. © 2020 Society of Chemical Industry.
A Preliminary Study on Metabolome Profiles of Buffalo Milk and Corresponding Mozzarella Cheese: Safeguarding the Authenticity and Traceability of Protected Status Buffalo Dairy Products

The aim of this study is to combine advanced GC-MS and metabolite identification in a robust and repeatable technology platform to characterize the metabolome of buffalo milk and mozzarella cheese. The study utilized eleven dairies located in a protected designation of origin (PDO) region and nine dairies located in non-PDO region in Italy. Samples of raw milk (100 mL) and mozzarella cheese (100 g) were obtained from each dairy. A total of 185 metabolites were consistently detected in both milk and mozzarella cheese. The PLS-DA score plots clearly differentiated PDO and non-PDO milk and mozzarella samples. For milk samples, it was possible to divide metabolites into two classes according to region: those with lower concentrations in PDO samples (galactopyranoside, hydroxybuthyric acid, allose, citric acid) and those with lower concentrations in non-PDO samples (talopyranose, pantothenic acid, mannobiose, etc.,). The same was observed for mozzarella samples with the proportion of some metabolites (talopyranose, 2, 3-dihydroxypropyl icosanoate, etc.,) higher in PDO samples while others (tagatose, lactic acid dimer, ribitol, etc.,) higher in non-PDO samples. The findings establish the utility of GC-MS together with mass spectral libraries as a powerful technology platform to determine the authenticity, and create market protection, for “Mozzarella di Bufala Campana. ”
Human Mutation

Division of Pediatric Neurology and Metabolic Medicine, Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany Heidelberg Research Center for Molecular Medicine (HRCMM), Heidelberg, Germany Department of Molecular and Human Genetics, Baylor College of Medicine and Texas Children’s Hospital, Houston, Texas Division of Neurodevelopmental Pediatrics and Neurogenetics, Children’s National Health System and The George Washington School of Medicine, Washington, District of Columbia
Transcriptome Analysis Unravels Metabolic and Molecular Pathways Related to Fruit Sac Granulation in a Late-Ripening Navel Orange (Citrus sinensis Osbeck)

Lanelate navel orange (Citrus sinensis Osbeck) is a late-ripening citrus cultivar increasingly planted in China. The physiological disorder juice sac granulation often occurs in the fruit before harvest, but the physiological and molecular mechanisms underlying this disorder remain elusive. In this study, we found that fruit granulation of the late-ripening navel orange in the Three Gorges area is mainly caused by the low winter temperature in high altitude areas. Besides, dynamic changes of water content in the fruit after freezing were clarified. The granulation of fruit juice sacs resulted in increases in cell wall cellulose and decreases in soluble solid content, and the cells gradually became shrivelled and hollow. Meanwhile, the contents of pectin, cellulose, and lignin in juice sac increased with increasing degrees of fruit granulation. The activities of pectin methylesterase (PME) and the antioxidant enzymes peroxidase (POD), superoxide dismutase, and catalase increased, while those of polygalacturonase (PG) and cellulose (CL) decreased. Furthermore, a total of 903 differentially expressed genes were identified in the granulated fruit as compared with non-disordered fruit using RNA-sequencing, most of which were enriched in nine metabolic pathways, and qRT-PCR results suggested that the juice sac granulation is closely related to cell wall metabolism. In addition, the expression of PME involved in pectin decomposition was up-regulated, while that of PG was down-regulated. Phenylalanine ammonia lyase (PAL), cinnamol dehydrogenase (CAD), and POD related to lignin synthesis were up-regulated, while CL involved in cellulose decomposition was down-regulated. The expression patterns of these genes were in line with those observed in low-temperature treatment as revealed by qRT-PCR, further confirming that low winter temperature is associated with the fruit granulation of late-ripening citrus. Accordingly, low temperature would aggravate the granulation by affecting cell wall metabolism of late-ripening citrus fruit.
Combined Effects of NMES and Mendelsohn Maneuver on the Swallowing Function and Swallowing–Quality of Life of Patients with Stroke-Induced Sub-Acute Swallowing Disorders

It is necessary to identify how to improve the swallowing-related quality of life, as well as the swallowing function, in order to evaluate the effect of treatments on swallowing disorders. This study aimed to prove the effects of a compound swallowing intervention (Mendelsohn maneuver + neuromuscular electrical stimulation (NMES)) on the swallowing function and the quality of life by applying the compound swallowing intervention to patients with sub-acute swallowing disorders due to cerebral infarction for eight weeks. This study analyzed 43 subjects who were diagnosed with swallowing disorders due to cerebral infarction. The experiment consisted of the Mendelsohn maneuver treatment group (n = 15), the NMES treatment group (n = 13), the compound intervention group (Mendelsohn maneuver + NMES; n = 15). The results of ANCOVA showed that the changes in Functional Dysphagia Scale (FDS) scores and Swallowing–Quality of Life (SWAL–QOL) score were different among groups. The compound intervention group had the highest FDS scores and SWAL–QOL score followed by Mendelsohn, and the NMES group had the lowest. The result of this study suggests that NMES can be more effective when it is combined with a traditional swallowing rehabilitation therapy rather than a single intervention method.
Highly Crystalline and Semiconducting Imine‐Based Two‐Dimensional Polymers Enabled by Interfacial Synthesis

Abstract Single‐layer and multi‐layer 2D polyimine films have been achieved through interfacial synthesis methods. However, it remains a great challenge to achieve the maximum degree of crystallinity in the 2D polyimines, which largely limits the long‐range transport properties. Here we employ a surfactant‐monolayer‐assisted interfacial synthesis (SMAIS) method for the successful preparation of porphyrin and triazine containing polyimine‐based 2D polymer (PI‐2DP) films with square and hexagonal lattices, respectively. The synthetic PI‐2DP films are featured with polycrystalline multilayers with tunable thickness from 6 to 200 nm and large crystalline domains (100–150 nm in size). Intrigued by high crystallinity and the presence of electroactive porphyrin moieties, the optoelectronic properties of PI‐2DP are investigated by time‐resolved terahertz spectroscopy. Typically, the porphyrin‐based PI‐2DP 1 film exhibits a p‐type semiconductor behavior with a band gap of 1.38 eV and hole mobility as high as 0.01 cm2 V−1 s−1, superior to the previously reported polyimine based materials.
Indocyanine Green Loaded Polymeric Nanoparticles: Physicochemical Characterization and Interaction Studies with Caco-2 Cell Line by Light and Transmission Electron Microscopy

Biomedical applications of nanoparticles (NPs) have reached an increasing development in recent years. Recently, we demonstrated that newly synthesized poly (ethyl 2-cyanoacrylate) nanoparticles (PECA-NPs) are possible antitumor agents due to their cytotoxicity for cancer cells. Indocyanine green (ICG), an amphiphilic tricarbocyanine fluorescent dye, is widely used for the detection of tumoral extension in different organs during clinical surgery. Moreover, this fluorescent agent is unstable and it has a rapid clearance in physiological conditions in vivo. In this study, ICG was charged in PECA-NPs to improve its aqueous stability and make easier its use for the identification of tumor cells. Microscopic and ultrastructural aspects concerning the related in vitro interactions between ICG-loaded NPs and tumor cell culture were investigated. Obtained results showed an effective stabilization of ICG; furthermore, color inclusions inside the cells treated with ICG-loaded NPs demonstrated the internalization of NPs with associated ICG. Transmission electron microscopy (TEM) analysis demonstrated the cytoplasmic presence of coated vesicles (Ø ≤ 100 nm), hypothesizing their involvement in the mechanism of endocytosis. Therefore, ICG-loaded NPs could be proposed as agents for tumor diagnosis, hypothesizing also in the future a specific therapeutic treatment.
Application of MRA in the diagnosis of intracrnial aneurysms

Objective:To study the principle and methodolgy of MRA in diagnosis of intracranial aneurysm,and also to assess the value of MRA in detecting intracranial aneurysm.Methods:MRA and MRI were performed in 30 patieats with intracranial aneurysms which were confirmed by digital subtraction angiography (DSA) and operation.Results:The sensitivity of MRA in detecting intracranial aneurysm was 90%. And it can be improved up to 97% when combin MRA with MRI.The site,size and morphology of aneurysms more than 3mm in diameter and its relation to supply artery were more accurately demonstrated by MRA.MRA is better than DSA in detecting the thrombosed parts of the aneurysms.Conclusion:MRA is a effective and non invasive diagnostic methoo for intracranial aneurysm.It may replace DSA in detecting the willis circle aneurysm.
Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome

SCN8A encephalopathy is a developmental and epileptic encephalopathy (DEE) caused by de novo gain‐of‐function mutations of sodium channel Nav1.6 that result in neuronal hyperactivity. Affected individuals exhibit early onset drug‐resistant seizures, developmental delay, and cognitive impairment. This study was carried out to determine whether reducing the abundance of the Scn8a transcript with an antisense oligonucleotide (ASO) would delay seizure onset and prolong survival in a mouse model of SCN8A encephalopathy.