Miracle-dz/UniFAR-FTUs huggingface dataset:
The TransformingTransport Project – Mobility Meets Big Data

Big data is expected to have a profound economic and societal impact in mobility and logistics. Examples in-clude 500 billion USD in value worldwide in the form of time and fuel savings, and savings of 380 megatons CO2. With freight transport activities projected to increase by 40% in 2030, transforming the current mobility and logistics processes to become significantly more efficient, will have a profound impact. A 10% efficiency improvement may lead to EU cost savings of 100 billion EUR. Despite these promises, interestingly only few mobility and logistics companies employ big data solutions as part of value creation and business processes. The TransformingTransport project (http://www.transformingtransport.eu) will demonstrate, in a realistic, meas-urable, and replicable way the transformations that big data can bring to the mobility and logistics market. Structured into 13 different pilots, which cover areas of major importance for the mobility and logistics sector in Europe, TransformingTransport validates the technical and economic viability of big data to reshape transport processes and services. To this end, TransformingTransport exploits access to industrial data sets from over 160 data sources, totalling 410,000 GB. Starting with the explanation the structure and aims of the 13 pilots, we provide the key main characteristics of the involved data sets in terms of variety, volume, and velocity. We explain the methodology of the project to achieve replicability and scalability of its results in particular to cope with data volume and velocity. We provide concrete examples for the innovation potential and impact of the project outcomes, including gains in operational efficiency, improved customer experience and new business models made possible when mobility meets big data. We conclude with a critical discussion on data management concerns.
Genome-wide analysis and expression characterization of zinc finger homeodomain (ZHD) family genes responsed to different abiotic stresses and hormonal treatments in grape (Vitis vinifera L.)

Background Zinc finger homeodomain (ZHD) proteins transcription factors (TFs) family occupy a crucial role in regulating plant growth and development. The ZHD TFs family had been studied in diverse organisms such as humans, Drosophila, nematode worms and plants. Especially in plants there is an extensive exploration involved in photosynthesis, defense mechanisms and responses to stress. In this further research, we will provide a better understanding of the ZHD gene family in grape. Results In this study, a total of 12 VvZHD genes were identified from the Grape Genome. The exploration of detailed bioinformatics found that the full length of VvZHD genes ranges from 150 bp (base pair) to 26706 bp, isoelectric points (pIs) were 6.25–9.68, molecular weights (MWs) ranged from 10.28 kilodaltons (KDa) to 97.93 kDa. Also, analysis of phylogenetic evolution showed there existed a common ancestor between Arabidopsis and grape. Ka (Nonsynonymous) / Ks (Synonymous) was lower than 1 and strong collinearity showed there were tandem duplications of genes between Arabidopsis and grape. Codon bias levels of ZHD gene family were relatively higher overall. Gene chip data analysis of cabernet sauvignon seedlings showed VvZHD genes had different expression under different time of different treatments, and with the prolongation of treatment time, most of VvZHD genes were slightly downregulated. The qRT-PCR was carried out under different hormones and stresses to verify expression profiles in grape roots and leaves. Results revealed that most VvZHD genes had higher expressions in roots but lower expressions in leaves. Also, most of the VvZHD gene members were responsed with high expressions after the treatment of ABA, IAA and MeJA in roots. However, VvZHD9, VvZHD11 and VvZHD12 were highly expressed by inducing of PEG in leaves. Conclusions Through genome-wide analysis and expression characterization of ZHD family genes, results showed 12 members had the diversity of function, structure and unique expression characterization under various abiotic stress and hormone treatments. This study will provide us with a newer insight on ZHD gene family of grape and promote to explore the biological functions of ZHD genes in other plants.
The analgesic efﬁcacy of sciatic nerve block in addition to femoral nerve block in patients undergoing total knee arthroplasty: a systematic review and meta-analysis*

Summary The aim of this meta-analysis was to assess the postoperative analgesic ef ﬁ cacy of sciatic nerve block when combined with femoral nerve block after total knee arthroplasty. Outcomes included resting pain scores (analogue scale, 0 – 100), intravenous morphine consumption at 12 h, 24 h and 48 h postoperatively, and functional outcomes comprising knee ﬂ exion, distance walked, and length of stay. Twelve randomised controlled trials were included, with a total of 600 patients. When combined with femoral nerve block, sciatic nerve block signi ﬁ cantly reduced resting pain scores at 12 h postoperatively with a mean difference of 10 (95% CI: (cid:1) 15 to (cid:1) 5; p < 0.00001). Resting pain scores at 24 h, and intravenous morphine consumption at 12 h, 24 h and 48 h postoperatively were also signi ﬁ cantly reduced, but without clinical signi ﬁ cance beyond 12 h and without affecting functional outcomes. In conclusion, sciatic nerve block confers additional postoperative analgesia within the ﬁ rst 12 postoperative hours compared with femoral nerve block alone for patients undergoing total knee arthroplasty.
CYTOPROTECTIVE EFFECTS OF AQUEOUS GINGER ( ZINGIBER OFFICINALE ) EXTRACT AGAINST CARBIMAZOLE-INDUCED TOXICITY IN ALBINO RATS

Carbimazole is an antithyroid drug used to treat over active thyroid gland. On the other hand treatment with carbimazole associated with many side effects. In our research, rats treated with carbimazole for three and six weeks showed significant increase in percentage of apoptotic and necrotic cells by using dual staining of leucocytes by acridine orange and ethidium bromide. Moreover DNA fragmentation was observed after six weeks of treatment with carbimazole. Also comet assay revealed DNA damage in rats treated with carbimazole for six weeks. An increase in chromosomal aberrations were recorded with decreased cell proliferation was reflected by a decrease in mitotic index. Combined treatment with aqueous ginger ( Zingiber officinale ) extract and carbimazole caused a reduction in chromosomal aberrations, DNA damage and increasing cell viability by decraesing apoptotic and necrotic percentage with an increase in mitotic index. The results of this study indicated that aqueous ginger extract ameliorates the genotoxicity and cytotoxicity induced by carbimazole in albino rats and this is may be due to the potent antioxidant effects of its components.
Gene expression level of toll-like receptor 4 and insulin receptor substrate 1 in type II diabetic Malay patients and their first-degree relatives.

Background: Type II diabetes mellitus (T2DM) is a polygenic disorder that can be prevented or delayed in case of the adoption of proper interventions. The identification of susceptible genes and novel biomarkers of T2DM could be of great help in the early detection of high-risk individuals. First-degree relatives of T2DM patients have a high risk of this disease, even when they have no major abnormalities in glucose metabolism. The present study was conducted to examine the status of the expression of two genes, namely toll-like receptor 4 (TLR4) and insulin receptor substrate (IRS1), involved in glucose metabolism in peripheral blood, in individuals genetically predisposed to T2DM development. Methods: Blood samples were collected from 54 participants in three research groups, including Malay subjects with T2DM, first-degree relatives of T2DM patients, and healthy controls. The measurement of gene expression was accomplished using a quantitative real-time polymerase chain reaction. Result: The results were indicative of the significant upregulation and downregulation of TLR4 in patients with T2DM and their first-degree relatives, respectively (P<0.05). With regard to IRS1, the data revealed a decreased expression in T2DM patients as compared to that in the healthy controls (p<0.05). Conclusion: The results indicated that TLR4 and IRS1 might be involved in the pathogenesis of T2DM. Moreover,the altered expression of TLR4 in the first-degree relatives of diabetic patients is an important marker showing a genetic predisposition to T2DM. Therefore, the two investigated genes could be used as a diagnostic tool for the prediction of T2DM in this population.
Can the Three-Dimensional Heads-Up Display Improve Ergonomics, Surgical Performance, and Ophthalmology Training Compared to Conventional Microscopy?

Purpose: To explore ophthalmic surgeons’ opinions regarding three-dimensional heads-up display (3D HUD) use and investigate musculoskeletal (MSK) complaints among ophthalmologists. Methods: Physicians were invited to complete an online questionnaire. Musculoskeletal complaints and data of the HUD system use were correlated with demographic information. We explored surgeons’ feedback on image quality, depth perception, and the educational value of 3D microscopy. Results: In this study, the prevalence of self-reported MSK pain was 82.6% (n=132). The pain started after joining ophthalmology practice and significantly improves on weekends and vacations. We found that the pain intensity in non-HUD users is higher than in HUD users, but this correlation was not statistically significant. Sixty-one (84.7%) of HUD system users were satisfied with depth perception, and 27 (37.5%) reported improvement in peripheral acuity. Thirty-seven (51.4%) of the participants believed they perform surgeries better through HUD; this was why most participants (83.3%) recommended its use in surgical training. Conclusion: Heads-up display use provides more comfortable sitting positions for surgeons, superior depth perception, and serves as a better educational tool. We believe that adopting this technology may help improve career longevity and productivity.
(REFEREED RESEARCH)

Nowadays, added value of conventional ring yarns has been decreased therefore importance of core-yarns has been increasing whether producers or consumers. Because of reflecting the positive side of the both component to the new yarn structure by composing two different component, in the future it is reported that these yarns can be used especially in technical field. In this study, modified conventional ring spinning machine is presented in order to produce core-spun yarns with elastane and developed a software on behalf of controlling automatically this system. By changing different production parameters of machine, core-spun yarns with different elastane ratio has been produced by 100% cotton and 50/50% cotton/viscose roving. The effect of changed production parameters have been investigated by applying tensile strength (Rkm) and elongation (%) tests.
IMPACT OF AGRO-INDUSTRIAL BY-PRODUCTS ON SHEEP PERFORMANCE UNDER SEMI ARID CONDITIONS

The current study was carried out at Maryout research station, Desert Egypt. This experiment aimed at investigating substitution by 20% or 40% of concentrate feed mixture in Barki sheep rations by mixture (1:1) of date seeds and olive pulp that treated by 4% lime solution and incubated for 4 weeks to study their effects on growth performance, blood constituents and wool characteristics. Thirty Barki male lambs (5 months age) with average live body weight of 27.98±1.97 kg were assigned into three similar groups to be fed randomly on the experimental rations. The tested rations were, clover hay 30% plus CFM 70% (control, C), replace 20% (T1) and 40% (T2) of CFM in control ration by the same part of mixture of treated date seeds and olive pulp. Blood serum was analyzed to determine total protein (TP), albumin, Globulin Glucose, total lipids (TL) and urea. The serum electrolytes in terms of, Sodium (Na), potassium (K), and Calcium (Ca) concentrations were analyzed. Wool samples from 10 cm 2 patch of mid-side position were taken from each animal. Ten staples were taken randomly from each wool sample to measure staple length. Five hundred fibers from each sample were used to calculate the average fiber diameter and its standard deviation as well as medullated fiber percentage. Results indicated that, the best feed conversion were recorded for the control group followed by Treatment 1 (T1) group and then Treatment 2 (T2) group. There was a linear decrease in the average daily gain with increasing the percentage of concentrate mixture substitution by the mixture of treated date seeds and olive pulp. Sampling time for all the experimental rations except T1 have significant (P<0.05) effect on blood glucose concentrations. The experimental rations have no significant effect on blood serum total protein concentration. However, sampling time showed significant (P<0.05) effect only for lamb group fed on ration T2. The experimental rations have no significant effect on blood urea concentration. Results showed that staple strength was higher significantly (P<0.05) in control group (21.54 N/Ktex) than T2 group (18.74 N/Ktex). The same trend was found for point of break compared to the other two groups (45.42, 34.41, and 33.16%), respectively. In conclusion, 20 or 40% of CFM could be replaced by a mixture of lime treated date seeds and olive pulp (1:1) in Barki lambs rations with slight improve for some wool characteristics and without adverse effect on some blood parameters.
CMAR_A_233448 7983..7992

Liver Disease Center, The Affiliated Hospital of Qingdao University, Qingdao 266003, People’s Republic of China Objective: To investigate the effects of fatigue on the survival of patients with advanced hepatocellular carcinoma treated with sorafenib. Patients and Methods: A retrospective analysis of 182 cases of patients with advanced hepatocellular carcinoma treated with sorafenib in our hospital from October 1, 2008, to October 31, 2017, showed clinical and pathological data and follow-up results. The clinical and pathological data as well as follow-up results of 182 patients with advanced hepatocellular carcinoma treated with sorafenib in our hospital from October 1, 2008, to October 31, 2018, were retrospectively analyzed. All patients were treated for at least 3 months. Patients were divided into three groups: fatigue grade I (n=74), fatigue grade II (n=62), and fatigue grade III (n=46), according to National Cancer Institute common terminology criteria for adverse events (NCI CTCAE) version 5.0. Survival analysis between groups was performed by the Kaplan–Meier method (Log rank test), continuous variables were analyzed by t-test, and categorical variables were analyzed by chi-square test. Results: The overall survival (OS) of patients who were relieved of fatigue was 33.0±9.3 months, whereas the OS of patients who were not relieved of fatigue was 15.0±1.8 months (P<0.000). Furthermore, the time to progress (TTP) of patients who were relieved of fatigue by resting was 20.3 ± 10.9 months compared to a TTP of 7.7 ± 1.0 months in patients who were not relieved of fatigue (P<0.000). Conclusion: Patients, especially the elderly and infirm, were more susceptible to toxicity.
Performance driven circuit partitioning

Circuit partitioning divides a given circuit into a collection of smaller subcircuits while satisfying the given area and/or pin constraints. In order to keep up with the rapid increase of system complexity due to substantial advances in VLSI process technology, partitioning is performed at various level of design hierarchy until subproblems become more manageable. The conventional objective of partitioning is to minimize the interconnect among the partitioned circuits. On the other hand, under the new interconnect-centric design paradigm, partitioning is seen as the crucial step that defines the local and global interconnects [Con99]. To meet the performance requirement of today's complex design, performance driven partitioners must consider the amount of interconnect induced by partitioning (measured by its cutsize) as well as its impact on performance (measured by its delay). Many proposed cutsize driven partitioners do not consider delay, while many proposed delay driven partitioners do not consider cutsize. As a result, there is a strong need for a performance driven partitioner that considers both cutsize and delay and provides smooth cutsize/delay tradeoff. This dissertation studies the performance driven circuit partitioning problem under the objective of simultaneous cutsize and delay minimization. Our focus is first to identify and analyze the limitation of current state-of-the-art in cutsize driven and delay driven partitioners, and then to develop efficient, effective, and scalable solutions for simultaneous cutsize and delay minimization for today's large scale circuits. Our proposed solutions include (i) modified iterative improvement methods [CLL+97, CL98, WLCS00, CL00c], (ii) multi-level methods [CL00a, CLW00], and (iii) geometric embedding method [CL00b].
biogeography of abundant and rare bacterioplankton in the lakes and of

22 Bacteria play key roles in the ecology of both aquatic and terrestrial ecosystems, 23 however little is known about their diversity and biogeography, especially in the rare 24 microbial biosphere of inland freshwater ecosystems. Here we investigated aspects of 25 the community ecology and geographical distribution of abundant and rare 26 bacterioplankton using high-throughput sequencing and examined the relative 27 inﬂuence of local environmental variables and regional (spatial) factors on their 28 geographical distribution patterns in 42 lakes and reservoirs across China. Our results 29 showed that the geographical patterns of abundant and rare bacterial subcommunities 30 were generally similar, and both of them showed a significant distance-decay 31 relationship. This suggests that the rare bacterial biosphere is not a random assembly, 32 as some authors have assumed, and that its distribution is most likely subject to the 33 same ecological processes that control abundant taxa. However we identified some 34 differences between the abundant and rare groups as both groups of bacteria showed a 35 signiﬁcant positive relationship between sites occupancy and abundance, but the 36 abundant bacteria exhibited a weaker distance–decay relationship than the rare 37 bacteria. Our results implied that rare subcommunities were mostly governed by local 38 environmental variables, whereas the abundant subcommunities were mainly affected 39 by regional factors. Additionally, both local and regional variables which were 40 significantly related to the spatial variation of abundant bacterial community 41 composition were different to those of rare ones, suggesting that abundant and rare 42 bacteria may have discrepant ecological niches and may play different roles in natural 43 ecosystems.
Physical Layer Security In Autonomous Driving Based Non-Competitive Distributed Consensus Scheme

This paper presents autonomous driving using a non-competitive distributed consensus scheme for physical layer security. The non-competitive distributed consensus scheme provides decentralization, security, and scalability as compared with the existing distributed consensus scheme. The non-competitive distributed consensus scheme makes it possible to share real-time traffic information in autonomous driving by achieving block generation within a relatively short time before consensus. Proposed traffic information communication method for autonomous driving is basically configured to generate a temporary block for a blockchain with traffic information only at vehicle nodes that have secured a certain level of secrecy capacity. Since secrecy capacity can be controlled by each vehicle node, it is expected that physical layer security will be enhanced in traffic information communications. This study is expected to contribute to reliably securing physical layer security in the commercialization of autonomous driving.
CloudMediate Peer-to-peer Media Aggregation for Augmented Reality

—Augmented Reality strives to produce a world composed from virtual models and multiple multi-media streams, and enables complete immersion into the result via modern mobile hand-held or wearable devices. In this paper, we present a conceptual media aggregation framework that is flexible, powerful and scalable to identify, establish and manage connections to media stream source (virtual and real) and produces an adaptable world view, which is then made available to consuming devices with attitude feedback. The framework is structured into three layers: presence, integration, and homogenization layers that work together in a peer-to-peer (p2p) manner to facilitate the delivery of multimedia data. Each layer features cloud-based mediator components, each mediator transforms an input stream into an output stream. This mediation process is context-aware, adaptive and dynamically structured.
Inhibition of Papain by S -Nitrosothiols: Formation of Mixed Disulfides*

free thiol groups per enzyme molecule were titrated after incubating the enzyme (1 mg/ml) with S nitrosothiols (0.5 mM) for 30 minutes, whereas 0.81 free thiol groups were titrated in the uninhibited enzyme. These results also indicated that the sulfhydryl group in the active site of papain (Cys25) is involved in the enzyme inactivation, and the modification of this sulfhydrl group by inactivators was complete.
Recombinant ai-3 Subunit of G Protein Activates Gk-gated K+ Channels*

this contain approximately equal activities when assayed in the presence of 10 p~ GTPrS, which in turn was equivalent to of in the final Similar results were obtained on several additional occasions. ra,(short), induced by the two-plasmid method, was purified partially by DEAE-Sephacel chromatography in its form, by ultrafiltration in and for activity the presence purified
Breaking the Barriers of Internationalization through Marketing:

This thesis explores how the resources of marketing capabilities, business networks, and financial resources, influence the marketing approach of international new ventures. Building on the resource based view, the market entry of firms and how they compete is analyzed by exploring the resources and capabilities of INVs. By using a qualitative research method, this thesis identifies the three resources of marketing capabilities, business networks, and financial resources to be highly influential for INVs’ marketing approach. Also there has been shown to be a synergetic effect between the resources, and that the cross-industrial and cross-business type sampling did not entail any divergences, but rather similar patterns. Four main findings can be identified as a result of our analysis. First, market knowledge prior to internationalization is shown to be key. Second, the creation of trust through transparency in business networks spark business network opportunities and long-term relationships. Third, utilizing technological tools for marketing endeavors becomes highly efficient. Fourth, tackling financial limitations through the implementation of a low-cost strategy is shown to be essential. The findings of this research has great potential of contributing to managerial practice when working with marketing aspirations, as well as being a starting point for future research in the field of INVs and the resource based view theory. The study has limitations in regards to the scope of the research.