Miracle-dz/UniFAR-FTUs huggingface dataset:
Title Synergistic study of a Danshen ( Salvia Miltiorrhizae Radix et Rhizoma ) and Sanqi ( Notoginseng Radix et Rhizoma )

Background: This study investigated the protective effects of the Danshen (DS) and Sanqi (SQ) herb pair on cell survival in the human cardiovascular endothelial (EA.hy926) cell line exposed to injury. Methods: Nine combination ratios of Danshen-Sanqi extracts (DS-SQ) were screened for their protective effects in the EA.hy926 cell line against two different cellular impairments induced by DL-homocysteine (Hcy) – adenosine (Ado) – tumour necrosis factors (TNF) and oxidative stress (H2O2), respectively. The type of interaction (synergistic, antagonistic, additive) between DS and SQ was analysed using a combination index (CI) model. The effects of key bioactive compounds from DS and SQ were tested using the same models. The compound from each herb that demonstrated the most potent activity in cell viability was combined to evaluate their synergistic/antagonistic interaction using CI. Results: DS-SQ ratios of 6:4 (50–300 μg/mL) produced synergistic effects (CI < 1) in restoring cell viability, reducing lactate dehydrogenase (LDH) leakage and caspase-3 expressions against Hcy-Ado-TNF. Additionally, DS-SQ 6:4 (50–150 μg/mL) was found to synergistically protect endothelial cells from impaired cellular injury induced by oxidative damage (H2O2) by restoring reduced cell viability and inhibiting excessive expression of reactive oxygen species (ROS). In particular, the combination of salvianolic acid A (SA) and ginsenoside Rb1 (Rb1) at 4:6 (1–150 μM) showed synergistic effects in preventing cytotoxic effects caused by Hcy-Ado-TNF (CI < 1). This simplified combination also demonstrated synergistic effects on H2O2-induced oxidative damage on EA.hy926 cells. Conclusions: This study provides scientific evidence to support the traditional use of the DS-SQ combination on protecting endothelial cells through their synergistic interactions.
redictability of marine nematode biodiversity

In this paper, we investigated: (1) the predictability of different aspects of biodiversity, (2) the effect of spatial autocorrelation on the predictability and (3) the environmental variables affecting the biodiversity of free-living marine nematodes on the Belgian Continental Shelf. An extensive historical database of free-living marine nematodes was employed to model different aspects of biodiversity: species richness, evenness, and taxonomic diversity. Artificial neural networks (ANNs), often considered as “black boxes”, were applied as a modeling tool. Three methods were used to reveal these “black boxes” and to identify the contributions of each environmental variable to the diversity indices. Since spatial autocorrelation is known to introduce bias in spatial analyses, Moran’s I was used to test the spatial dependency of the diversity indices and the residuals of the model. The best predictions were made for evenness. Although rtificial neural networks species richness was quite accurately predicted as well, the residuals indicated a lack of performance of the model. Pure taxonomic diversity shows high spatial variability and is difficult to model. The biodiversity indices show a strong spatial dependency, opposed to the residuals of the models, indicating that the environmental variables explain the spatial variability of the diversity indices adequately. The most important environmental variables structuring evenness are clay and sand fraction, and the minimum atte e sea annual total suspended m the amount of gravel of th
Quasi-bireciprocal and Multirate Wave Digital Lattice Filters

[17] LID, T. ; Kawamata, M. : A counter-example to 2-D Lyapunov equations by Mertzios. [20] Fettweis, A. : Reciprocity, inter-reciprocity, and transposition in IEEE Trans. Circuits Syst. CAS-32 (1985) S. 1310—1311. Int. J. Circuit Theory AppL 1 (1973) S. 323—337. [18] Fettweis, . : Pseudopassivit), sensitivity, and stability of wave digital filters. IEEE Trans. Circuit Theory CT-19 (1972) S. 668—673. [19] Meerkötter, K. : Antimetric wave digital filters derived from complex reference circuits, Proc. Ear. Conf. Circuit Theory and Design, Stuttgart, Sept 1983. wave digital filters.
lncRNA-D16366 Is a Potential Biomarker for Diagnosis and Prognosis of Hepatocellular Carcinoma

Background Long non-coding RNAs (lncRTNAs) are a new focus in cancer research. Although lncRNAs have no protein coding capacity, they are important in epigenetics as well as in regulating gene expression, playing an important role in various cancers. In the current study, we investigated the roles of lncRNA-D16366 in hepatocellular carcinoma (HCC) and expected to find a new biomarker for early detection and prognosis of the disease. Material/Methods Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression of lncRNA-D16366 in tissue and serum samples. The relationship between lncRNA-D16366 expression and clinicopathologic characteristics of patients with HCC was analyzed to estimate whether it was involved in malignancy development. Then, potential diagnostic and prognostic values were evaluated via receiver operating characteristic (ROC) curve, Kaplan-Meier and Cox regression analysis, respectively. Results lncRNA-D16366 was proved to be decreased in the tissues and serum among patients with HCC compared with the corresponding controls. Its expression was influenced by tumor size, HbsAg, portal vein tumor thrombus, Child-Pugh score, therapies, and neoplasm metastasis. It had high diagnostic value, with an AUC of 0.752, accompanied by a sensitivity of 65.5% and a specificity of 84.6%. In addition, it was related to the prognosis of HCC. Conclusions lncRNA-D16366 was decreased in HCC, and might be an independent diagnostic and prognostic indicator in the disease.
Succinate dehydrogenase inhibitor dimethyl malonate alleviates LPS/d-galactosamine-induced acute hepatic damage in mice

In addition to its energy-supplying function, increasing evidence suggests that mitochondria also play crucial roles in the regulation of inflammation. Succinate dehydrogenase is also known as mitochondrial complex II, and inhibition of succinate dehydrogenase by dimethyl malonate has been reported to suppress the production of pro-inflammatory cytokines. In the present study, the potential anti-inflammatory benefits of dimethyl malonate were investigated in a mouse model with LPS/d-galactosamine-induced acute hepatic damage. Male BALB/c mice were injected i.p. with LPS and d-galactosamine to cause liver injury. The degree of liver injury, inflammatory response and oxidative stress and the survival of the experimental animals were determined. The results indicated dimethyl malonate decreased the level of aminotransferases in plasma, alleviated histological abnormalities in liver, inhibited the induction of TNF-α and IL-6 in plasma, suppressed hepatocyte apoptosis and improved the survival of LPS/d-galactosamine-exposed mice. Therefore, inhibition of succinate dehydrogenase by dimethyl malonate significantly alleviated LPS/d-galactosamine-induced hepatic damage, which suggests that succinate dehydrogenase might become a novel target for the intervention of inflammation-based hepatic disorders.
Context Awareness Reinhard Oppermann From User-adaptive to Context-adaptive Information Systems

Sum ma ry. This paper introduces context-adaptive information systems reflecting the current needs of the user. Context-adaptive information systems reflect more than classical user-adaptive systems where user and task characteristics are considered for adaptation. In context-adaptive information systems the usage episode is additionally defined by the time and the location, by the physical and social environment and the technical infrastructure and eventually by relevant situational characteristic such as sound, light or movement. To begin with, the rationality of adaptive systems and the concept of context-adaptiveness will be explained. Based upon the description of the three functions of adaptivity, i.e., the interaction logging, adaptation inference and adaptation performance, we describe user-adaptive and context-adaptive systems and the role sharing between the system and the user during the adaptation process. Techniques of location-awareness as currently an important determinant of context are described showing advantages and disadvantages for several application scenarios. At the end, application examples are presented for context-adaptive systems to understand the utility of context-adaptiveness in different fields of information and communication services. Zu sam men fas sung. Das Papier führt in kontextadaptive Informationssysteme ein, die die aktuellen Bedürfnisse des Benutzers berücksichtigen. Kontextadaptivität reflektiert mehr Dimensionen als klassische benutzeradaptive Systeme, die Benutzerund Aufgabeneigenschaften berücksichtigen. In kontextadaptiven Systemen definieren zusätzlich Merkmale der Zeit und des Ortes, der physikalischen und sozialen Umgebung und technischen Infrastruktur sowie evtl. relevanter situationaler Merkmale wie Geräusche, Lichtverhältnisse oder Bewegungen die Benutzungsepisode. Zunächst werden das Rationale adaptiver Systeme und das Konzept der Kontextadaptivität erläutert. Basierend auf der Beschreibung der drei Funktionen von Adaptivität, der Beobachtung, der Schlussfolgerung und der Ausführung von Adaptivität werden benutzeradaptive und kontextadaptive Systeme und die Rollenverteilung zwischen System und Benutzer innerhalb der Adaptionsprozesses dargestellt. Techniken der Ortung als aktuell wesentliches Merkmal des Kontextes werden beschrieben und deren Vorund Nachteile für verschiedene Anwendungsumgebungen aufgezeigt. Im letzten Teil werden Beispielanwendungen von kontextadaptiven Systemen aus der eigenen Entwicklung vorgestellt, um die Nützlichkeit der Kontextadaptivität in verschiedenen Feldern von Informationsund Kommunikationsdiensten verstehbar zu machen.
The Impact of Domain Randomization on Object Detection: A Case Study on Parametric Shapes and Synthetic Textures*

Recent advances in deep learning–based object detection techniques have revolutionized their applicability in several fields. However, since these methods rely on unwieldy and large amounts of data, a common practice is to download models pre-trained on standard datasets and fine-tune them for specific application domains with a small set of domain–relevant images. In this work, we show that using synthetic datasets that are not necessarily photo-realistic can be a better alternative to simply fine-tune pre-trained networks. Specifically, our results show an impressive 25%improvement in the mAP metric over a fine-tuning baseline when only about 200 labelled images are available to train. Finally, an ablation study of our results is presented to delineate the individual contribution of different components in the randomization pipeline.
Impaired empathy but no theory of mind deficits in adult attention deficit hyperactivity disorder

The cognitive capacity to change perspective is referred to as theory of mind (ToM). ToM deficits are detectable in a variety of psychiatric and neurological disorders. Since executive abilities are closely associated with ToM skills, we suspected that due to a common neuropsychological basis, ToM deficits exist in treatment‐naïve adults with attention‐deficit/hyperactivity disorder (ADHD).
In familial Mediterranean fever, soluble TREM-1 plasma level is higher in case of amyloidosis

We aimed to explore triggering receptor expressed on myeloid cells-1 (TREM-1) activation in familial Mediterranean fever (FMF), the most frequent monogenic auto-inflammatory disease, through the measurement of its serum soluble form, named sTREM-1. Blood samples from patients with FMF according to Livneh criteria followed in the French FMF national center and carrying two pathogenic MEFV mutations were collected. Serum level of sTREM-1 was assessed using ELISA. Demographic data, presence of FMF attack, association with histologically proven AA amyloidosis, and blood levels of C-reactive protein (CRP), serum amyloid A (SAA) protein, and creatinine were collected. TREM-1 was available in 56 patients (33.9% male, mean age 43 yr); AA amyloidosis was associated in six patients (19.6% in FMF). Mean sTREM-1 level did not differ significantly between patients having an attack or not and there was also no significant correlation between the level of sTREM-1 and CRP and SAA protein. However, the mean rate of sTREM-1 was significantly higher among FMF patients with AA amyloidosis versus without, though the concomitant SAA protein level was normal. Serum level of sTREM-1 was higher in patients with amyloidosis even though the concomitant SAA protein level was normal. sTREM-1 plasma levels could be an accurate tool to specifically identify FMF patients with amyloidosis.
Dietary Phytochemical Index and Benign Breast Diseases: A Case–Control Study

Abstract Background: Dietary phytochemical index (DPI) is an inexpensive method for estimating the amounts of phytochemicals in foods. No study has investigated the association of DPI and benign breast diseases (BBD). Our study aimed to compare DPI in patients with BBD and the control group. Subjects: This is a case–control study of 115 subjects with BBD and 116 healthy women attending the Iranian Center for Breast Cancer affiliated with Academic Center for Education, Culture and Research. Energy-adjusted DPI was calculated based on data collected from 168-item validated food frequency questionnaire. Sociodemographic data, physical activity, and anthropometric measures such as body weight, height, and waist circumference were determined. Results: After adjustment for age, estrogen therapy, family history of breast disease, intake of dietary supplement, menopause status, waist circumference and physical activity, the odds ratio (OR) of BBD across the energy-adjusted DPI quartiles decreased significantly (OR = 0.3, 95%CI = 0.12–0.93) (P‑trend = 0.02). Conclusion: We found that higher DPI score is related to lower BBD OR. This simple method may be used for the improvement of dietary intake to prevent BBD.
Tuning Oxygen Redox Chemistry in Li‐Rich Mn‐Based Layered Oxide Cathodes by Modulating Cation Arrangement

Li‐rich Mn‐based oxides (LRMO) are promising cathode materials to build next‐generation lithium‐ion batteries with high energy density exceeding 400 W h kg−1. However, due to a lack of in‐depth understanding of oxygen redox chemistry in LRMO, voltage decay is not resolved thoroughly. Here, it is demonstrated that the oxygen redox chemistry could be tuned by modulating cation arrangement. It declares that the materials with Li/Ni disorder and Li vacancies can inhibit the formation of OO dimers. Because of the high chemical activity, OO dimers could accelerate lattice oxygen release and NiO/spinel formation. The samples without forming OO dimers show improved performance in suppressing oxygen overoxidation and mitigating cation dissolution. As a result, the optimized cathode exhibits a high capacity over 280 mA h g−1 at 0.1 C and a high plateau voltage of 3.58 V with a very low voltage decay of 1.6% after 150 cycles at 1 C. This study opens an attractive path in designing Li‐rich electrodes with stabilized redox chemistry.
Preoperative Mild Pericardial Effusion Is Associated With Perioperative Complications In Elderly Patients Following Hip Fracture Surgery

Abstract Background: The prevalence and prognostic value of mild pericardial effusion (MPE) has not been examined in patients undergoing non-cardiac surgery. Our study aimed to assess the frequency and prognostic value of MPE in elderly patients undergoing surgery for hip fracture. Methods: This is a single center, and retrospective study including elderly patients who underwent hip fracture surgery. The medical records of all patients, aged ≥65 years with femoral neck, intertrochanteric or subtrochanteric hip fracture undergoing surgery (intramedullary hip screw, sliding compression hip screw, hemiarthroplasty, or total hip arthroplasty) from June 2014 to June 2019 were analyzed. Patients with of multiple trauma and accidents were excluded. The MPE was defined as the presence of <10 mm pericardial effusion. The primary outcomes of the study were perioperative adverse medical events and length of stay in hospital. Results: A total of 462 patients (mean age 75.2 ± 11.7 years, and 53.5% female) were enrolled. MPE was detected in 72 patients (15.6%), and 62 patients (13.4%) experienced perioperative adverse medical events. Patients with MPE were older, had higher prevalence of diabetes, coronary artery disease, and heart failure, and had longer length of stay compared to patients without MPE. Univariate analysis showed a significant association between age, diabetes, coronary artery disease, American Society of Anesthesiologists status, MPE, and perioperative adverse events. After adjustment for age, demographics, and medical history, the presence of MPE remained as significant variable associated with perioperative complications (OR: 2.543, 95% CI: 1.173–3.469, p = 0.003). Conclusion: Our study is the first to demonstrate that the presence of MPE is associated with perioperative adverse events in elderly patients undergoing hip fracture surgery.
Prognostic power of a lipid metabolism gene panel for diffuse gliomas

Lipid metabolism reprogramming plays important role in cell growth, proliferation, angiogenesis and invasion in cancers. However, the diverse lipid metabolism programmes and prognostic value during glioma progression remain unclear. Here, the lipid metabolism‐related genes were profiled using RNA sequencing data from The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) database. Gene ontology (GO) and gene set enrichment analysis (GSEA) found that glioblastoma (GBM) mainly exhibited enrichment of glycosphingolipid metabolic progress, whereas lower grade gliomas (LGGs) showed enrichment of phosphatidylinositol metabolic progress. According to the differential genes of lipid metabolism between LGG and GBM, we developed a nine‐gene set using Cox proportional hazards model with elastic net penalty, and the CGGA cohort was used for validation data set. Survival analysis revealed that the obtained gene set could differentiate the outcome of low‐ and high‐risk patients in both cohorts. Meanwhile, multivariate Cox regression analysis indicated that this signature was a significantly independent prognostic factor in diffuse gliomas. Gene ontology and GSEA showed that high‐risk cases were associated with phenotypes of cell division and immune response. Collectively, our findings provided a new sight on lipid metabolism in diffuse gliomas.
Value of serum TORCH-specific antibody detection in assessment of neonatal jaundice

TORCH is the abbreviation of toxoplasma gondii (TOX), rubella virus (RV), cytomegalovirus (CMV) and herpes simplex virus (HSV) and other pathogenic microorganisms (Other). After infecting the newborn, these pathogenic microorganisms can cause multiple organ damage, of which hyperbilirubinemia is with the highest incidence[1]. The occurrence of hyperbilirubinemia is caused by abnormal metabolism of bilirubin, bilirubin generation is excessive and the discharge reduces, which causes the excessive accumulation of bilirubin in the body, characterized by jaundice and multiple organ damage. TORCH infection will activate the body's immune system and produce specific antibodies, and the content of serum TORCH-specific antibodies can assess the severity of pathogen infection, and then provide evidence for the severity of jaundice and the degree of organ damage. In the following research, the value of serum TORCH-specific antibody detection in assessment of neonatal jaundice was analyzed.
Tilburg University Measuring Subjective Survival Expectations

This paper analyzes the test-retest reliability of subjective survival expectations that are elicited on two widely used response scales: an 11-point scale from 0 to 10 and a full percentage scale from 0 to 100. We compare responses of the same individuals in two surveys fielded in the same month. Reliability is evaluated both at the level of reported probabilities and through a model that relates expectations to socio-demographic variables. Test-retest correlations of survival probabilities are between 0.5 and 0.7, similar to subjective well-being. Only 20% of probabilities are equal across surveys, but up to 61-77% are consistent once we account for rounding. Both scales perform similarly in terms on response rates, internal consistency and fifty-fifty answers. Models that analyze all probabilities jointly reveal similar associations between most covariates and the hazard of death in test and retest datasets. Moreover, expectations are persistent at the level of the individual and this unobserved heterogeneity is strongly correlated across surveys (r ≈ 0.8-0.9). Finally, we use a calibrated life cycle model to map survival expectations into wealth and labor supply. Though wealth accumulation is sensitive to expectations, correcting for rounding substantially improves reliability of simulated wealth profiles. Taken together this evidence suggests that the two elicitation scales yield reliable measures of expectations.
Association of lowering apolipoprotein B with cardiovascular outcomes across various lipid-lowering therapies: Systematic review and meta-analysis of trials

Aims The effect of therapeutic lowering of apolipoprotein B (apoB) on mortality and major adverse cardiovascular events is uncertain. It is also unclear whether these potential effects vary by different lipid-lowering strategies. Methods A total of 29 randomized controlled trials were selected using PubMed, Cochrane Library and EMBASE through 2018. We selected trials of therapies which ultimately clear apolipoprotein B particles by upregulating low-density lipoprotein receptor (LDL-R) expression (statins, ezetimibe, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, bile acid sequestrants) or therapies which reduce apolipoprotein B independent of LDL-R (cholesteryl ester transfer protein inhibitor, fibrates, niacin, omega-3 fatty acids) with sample size of ≥1000 patients and follow-up of ≥1 year. The meta-regression and meta-analyses were constructed using a random effects model. Results In 332,912 patients, meta-regression analyses showed relative risks of 0.95 for all-cause mortality (95% confidence interval 0.92–0.99) and 0.93 (0.88–0.98) for cardiovascular mortality for every 10 mg/dL decrease in apolipoprotein B by all interventions combined. Reduction in all-cause mortality was limited to statins (0.92 (0.86–0.98)). For MACE, the relative risk per 10 mg/dL reduction in apolipoprotein B was 0.93 (0.90–0.97) for all therapies combined, with both statin (0.88 (0.83–0.93)) and non-statin therapies (0.96 (0.94–0.99)). which clear apolipoprotein B by upregulating LDL-R showing significant reductions; whereas interventions which lower apolipoprotein B independent of LDL-R did not demonstrate this effect (1.02 (0.81–1.30)). Conclusion While both statin and established non-statin therapies (PCSK9 inhibitor and ezetimibe) reduced cardiovascular risk per decrease in apolipoprotein B, interventions which reduce apolipoprotein B independently of LDL-R were not associated with cardiovascular benefit.