Miracle-dz/UniFAR-FTUs huggingface dataset:
Discrete virus factories form in the cytoplasm of cells co-infected with two strains of the segmented dsRNA virus, infectious bursal disease virus (IBDV), that subsequently coalesce

The Birnaviridae family, responsible for major economic losses to poultry and aquaculture, are non-enveloped viruses with a segmented double-stranded (ds)RNA genome that replicate in discrete cytoplasmic virus factories (VFs). Reassortment is common, however, the underlying mechanism remains unknown given that VFs may act as a barrier to genome mixing. In order to provide new information on VF trafficking during dsRNA virus co-infection, we rescued two recombinant infectious bursal disease viruses (IBDVs) of strain PBG98 containing either a split GFP11- or Tetracysteine (TC)- tag fused to the VP1 polymerase (PBG98-VP1-GFP11 and PBG98-VP1-TC). DF-1 cells transfected with GFP1-10 prior to PBG98-VP1-GFP11 infection, or stained with ReAsH following PBG98-VP1-TC infection, had green or red foci in the cytoplasm respectively that co-localised with VP3 and dsRNA, consistent with VFs. The average number of VFs decreased from a mean of 60 to 5 per cell between 10 and 24 hours post infection (hpi) (p<0.001), while the average area increased from 1.24 μm2 to 45. 01μm2 (p<0.001), and live cell imaging revealed that the VFs were highly dynamic structures that coalesced in the cytoplasm. Small VFs moved faster than large (average 0.57μm/s at 16 hpi compared to 0.22 μm/s at 22 hpi), and VF coalescence was dependent on an intact microtubule network and actin cytoskeleton. During co-infection with PBG98-VP1-GFP11 and PBG98-VP1-TC viruses, discrete VFs initially formed from each input virus that subsequently coalesced 10-16 hours post-infection. We speculate that dsRNA virus reassortment requires VF coalescence, and the potential for reassortment increases at later time points in infection. Importance Reassortment is common in viruses with segmented double stranded (ds)RNA genomes. However, these viruses typically replicate within discrete cytoplasmic virus factories (VFs) that may represent a barrier to genome mixing. We generated the first replication competent tagged reporter birnaviruses, infectious bursal disease viruses (IBDVs) containing a split GFP11 or tetracysteine (TC) tag and used the viruses to track the location and movement of IBDV VFs, in order to better understand the intracellular dynamics of VFs from two different strains of dsRNA virus during a co-infection. Discrete VFs initially formed from each virus that subsequently coalesced from 10 hours pi. We hypothesise that VF coalescence is required for the reassortment of dsRNA viruses and the potential for reassortment increases later in the replication cycle. This study provides new information that adds to our understanding of dsRNA virus VF trafficking.
Assessment of evaporative and photochemical effects on asphaltene profiling of a heavy fuel oil

Abstract Oil fingerprinting is concerned with determining the chemical profile of a spilled oil to determine its origin, whether that be a vessel, well or other source. Asphaltenes are typically discarded in this process even though they are considered refractory in comparison to the volatile fraction and have the ability to provide valuable information in oil fingerprinting. A heavy fuel oil was exposed to evaporative and photochemical conditions to determine if the asphaltene fraction and asphaltene profiling were influenced by weathering. It was found that although evaporative weathering had a strong effect on the volatile fraction of the oil, it had no influence on the asphaltene fraction, and profiling of the asphaltene fraction using previously published methods was still possible. When the oil was exposed to photo-oxidative conditions using natural sunlight, the mass of the asphaltene fraction increased significantly. Attenuated Total Reflectance - Fourier Transform Infrared (ATR-FTIR) analysis demonstrated that the oxygen level in the asphaltene fraction also increased with photochemical weathering compared to evaporative weathering alone. Even though the asphaltene fraction changed under photo-oxidative conditions, it could still be used for source determination using previously published ATR-FTIR and pyrolysis GC-MS methods for profiling of the asphaltene fraction.
Results of a walk‐above vertical seismic profiling survey acquired at the Thônex‐01 geothermal well (Switzerland) to delineate fractured carbonate formations for geothermal development

This paper deals with the design, acquisition and processing of vertical seismic profiling data collected in 2016 at the directional Thônex‐01 geothermal well, drilled in 1993 in the Geneva Canton (Switzerland). The aim of the study was to obtain additional information from existing‐abandoned well for downhole geophysical characterization of potential geothermal reservoirs in the Geneva area. The main results obtained by this study allowed an improved subsurface image by multi‐offset acquisitions near and around the deviated well. Specifically we were able to (1) improve the velocity model of the Geneva Basin, which, at present, is only constrained by one unique deep exploration well, located at the south‐west of the basin, far away from the study area; (2) image the transition between the Tertiary Molasse siliciclastic sediments and the Mesozoic carbonates; (3) define an acquisition strategy for future vertical seismic profiling surveys in support of the geothermal exploration campaigns in the area. This study has demonstrated the value of vertical seismic profiling method for the refinement of the subsurface geology at local scale, and its usefulness to assist the planning of second well associated with geothermal doublets.
A technique for detecting diagnostic events in video channel of synchronous video and electroencephalographic monitoring data

In this paper, a technique for automated detecting diagnostic events in the video channel of video and electroencephalographic monitoring data is presented. The technique is based on the analysis of the quantitative features of facial expressions in images of video data. The analysis of video sequences is aimed at detecting a group of frames characterized by high activity of frame regions. For detecting the frames, a criterion computed from the optical flow is proposed. The preliminary results of the analysis of real clinical data are presented. The intervals of synchronous muscle and brain activity, which may correspond to an epileptic seizure, are detected. These intervals can be used for diagnosing epileptic seizures and distinguishing them from non-epileptic events. Requirements for video shooting conditions are formulated.
Spatially balanced sampling

In many ecological and natural resource settings, there may be a high degree of spatial structure or pattern to the distribution of target variable values across the landscape. For example, the number of trees per hectare killed by a bark beetle infestation may be exceptionally high in one region of a national forest and near zero elsewhere. In such circumstances it may be highly desirable or even required that a sample survey directed at estimation of total tree mortality across a forest be based on selection of random locations that have good spatial balance, i.e., locations are well spread over the landscape with relatively even distances between them. A simple random sample cannot guarantee good spatial balance. We present two methods that have been proposed for selection of spatially balanced samples: GRTS (Generalized Random Tessellation Stratified Sampling) and BAS (Balanced Acceptance Sampling). Selection of samples using the GRTS approach involves a complicated series of sequential steps that allows generation of spatially balanced samples selected from finite populations or from infinite study areas. Selection of samples using BAS relies on the Halton sequence, is conceptually simpler, and produces samples that generally have better spatial balance than those produced by GRTS. Both approaches rely on use of software that is available in the R statistical/programming environment. Estimation relies on the Horvitz–Thompson estimator. Illustrative examples of running the SPSURVEY software package (used for GRTS) and links to the SDraw package (used for BAS) are provided at http://global.oup. com/uk/companion/hankin.
“Deiksis” dalam Kumpulan Cerpen Al-Kabuus Tinjauan Sosiopragmatik

Abstrak Penelitian ini berupaya untuk menggambarkan pemakaian deiksis dalam teks terjemahan berbahasa Indonesia dari bahasa sumbernya, bahasa Arab. Deiksis dipahami sebagai bagian dari studi pragmatik, dengan begitu deiksis merupakan salah satu objek bidang kajian dari pragmatik. Masalah dalam penelitian ini: 1) bagaimanakah jenis-jenis deiksis; 2) bagaimanakan maksud dibalik penggunaan deiksis sosial pada kumpulan cerpen Al-Kabuus. Tujuan yang hendak dicapai dalam penelitian ini adalah: 1) untuk mendeskripsikan aneka jenis deiksis, 2) mendeskripsikan maksud penggunaan deiksis sosial pada kumpulan cerpen Al-Kabuus. Objek penelitian yang dikaji adalah jenis, maksud serta hubungan deiksis sosial dengan yang terdapat pada cerpen Al-Kabuus. Subjek penelitiannya adalah cerpen karya Najib Kailani yang diterjemahkan oleh Zuriyati. Data dalam penelitian ini adalah kata, frase, klausa, kalimat yang di dalamnya terdapat jenis dan maksud penggunaan deiksis sosial dalam cerpen Al-Kabuus. Sumber data dalam penelitian ini terdiri dari sumber data primer dan sumber data sekunder. Teknik pengumpulan data dalam penelitian ini dengan menggunakan dokumentasi. Hasil penelitian ini menunjukkan bahwa sebanyak 20 cerpen dari Al-Kabuus diperoleh 60 deiksis sosial, terdapat 5 deiksis sosial jenis gelar, 4 deiksis sosial jenis jabatan, 12 deiksis sosial jenis profesi, dan terdapat 36 deiksis sosial jenis julukan. --- Abstract This study attempted to describe the use of deixis in Indonesian language translation text from the source language, Arabic. Deixis understood as part of a pragmatic study, so deixis is one of the object field of study of pragmatics. The problem in this research: 1) how the types of deixis; 2) how is the intention behind the use of social deixis on a collection of short stories Al-Kabuus. Goals to be achieved in this research are: 1) to describe the various types of deixis, 2) describe the intended use of social deixis on a collection of short stories Al-Kabuus. The object of research by reviewing the type, purpose and relationship with the social deixis contained in Al-Kabuus short stories. Subject of research is the short story by Najib Kailani translated by Zuriyati. The data in this study are words, phrases, clauses, sentences in which there are different types and the intended use of social deixis in short stories Al-Kabuus. Sources of data in this study consisted of primary data sources and secondary data sources. Data collection techniques in this study using documentation. The results of this study indicate that as many as 20 short stories from Al-Kabuus obtained 60 social deixis, social deixis there are 5 types of titles, positions four types of social deixis, social deixis 12 kinds of professions, and social deixis there are 36 kinds of nicknames.
Finite Control Set Model Predictive Control for LCL-Filtered Grid-Tied Inverter With Minimum Sensors

Recently, finite control set model predictive control (FCS-MPC) has been successfully applied in the grid-tied inverter with the LCL filter. However, to achieve active damping and grid synchronization, many sensors are required, increasing cost, and complexity. In addition, a considerable computational delay should be addressed when it is experimentally implemented, which may degrade the performance of the overall system. In order to reduce the number of sensors, eliminate the computational delay, and enhance the control reliability of the system, a novel FCS-MPC strategy with merely grid-injected current sensors is proposed, which contains four compositions: virtual flux observer, state observer, delay compensation, and FCS-MPC algorithm based on estimations. A 3-kW/3-phase/110-V experimental platform is established to validate that utilizing the proposed observations-based control method with only grid-injected current sensors is capable to obtain satisfactory performance of grid synchronization and high-quality grid-injected current both under balanced and unbalanced grid voltage condition.
Perceptions of Racial Slurs Used by Black Individuals Toward White Individuals: Derogation or Affiliation?

Research suggests that racial slurs may be “reclaimed” by the targeted group to convey affiliation rather than derogation. Although it is most common in intragroup uses (e.g., “nigga” by a Black individual toward another Black individual), intergroup examples of slur reappropriation (e.g., “nigga” by a Black individual toward a White individual) are also common. However, majority and minority group members’ perceptions of intergroup slur reappropriation remain untested. We examined White (Study 1) and Black (Study 2) individuals’ perceptions of the reappropriated terms, “nigga” and “nigger” compared with a control term chosen to be a non-race-related, neutral term (“buddy”), a nonracial derogative term (“asshole”) and a White racial slur (“cracker”) used by a Black individual toward a White individual. We found that the intergroup use of reappropriated slurs was perceived quite positively by both White and Black individuals. Our findings have important implications for research on intergroup relations and the reappropriation of slurs.
Relationship of Intellectual Capital to Dynamic Capabilities in Village Credit Institutions

The focus and point of view on this study was the ability of organizational resources (research Base Value/RBV). It was related how the dynamic capability of an organization, especially the village credit institution from the intellectual capital perspective. This research was conducted to get a new update on how the unique configuration of intellectual capital can enhance the ability of companies to empower their dynamic capabilities in order to win the market for the micro finance sector in Bali. In order to identify and formulate the relationship between human capital, social capital, and organizational capital to dynamic capabilities. 109-
Health: A Game of Disease Progression

A patient develops different diseases over time. There is a lack of research looking into the development of diseases over hospital visits. In this paper, we present a step-by-step process to find the sequences of diseases developed over hospital visits. In addition, we applied game theory lens to analyze the decisions made by physicians while prescribing the drugs. We found interesting results showing physicians taking preemptive actions to reduce the mortality rate among the heart failure patients. Finally, we built classification models to diagnose all the give diseases using lab reports. We were able to classify all the diseases seven out of ten times correctly. Our process and interesting findings can help medical community in improve their decision making related to the health outcomes.
Differential diagnosis of cervical lymphoma and lymph node metastases by dual-source dual-energy CT imaging

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The role of social and emotional learning during the transition to secondary school: an exploratory study

ABSTRACT Transitioning from primary school to secondary school is an important and defining stage for many pupils which can bring both positive and negative effects on pupil’s wellbeing. It is a time that involves rapid physical, social and emotional development which can bring about feelings of loneliness, pressure of social acceptance, stress and a rise in depression and anxiety. While not all pupils will experience negative transition-related challenges, and post transition anxiety may settle within the first term, for a number of pupils the transition is an overwhelming process which requires a lot of support. Yet, little is known about the supportive relational practices that might attenuate the challenges pupils face as they move to secondary school. This article investigated the experiences of 8 newly transitioned Year 7 pupils as well as viewpoints and perceptions of 6 secondary school teachers. Specifically, the paper sought to understand the role of social and emotional learning (SEL) during the transition phase and the support systems in place to develop the pupils. The results from the semi-structured interviews highlighted the importance of belonging during this critical phase, followed by the need to improve the social processes and transitional support. Thus, in designing transition support activities, such efforts should strive to acclimate new secondary school pupils by providing inclusive, caring environments and positive connections with educators and peers.
Persönliche Elektronische Patientenakte: Die Digitalisierung der Patient Journey

Die am Universitätsklinikum Heidelberg entwickelte Persönliche Gesundheits- und Patientenakte (PEPA) ermöglicht den einrichtungsübergreifenden, elektronischen Datenaustausch des Universitätsklinikums mit seinen Partner-Krankenhäusern, mit niedergelassenen Ärzten und den Patienten in der Metropol-region Rhein-Neckar.
Changes in Nutritional State and Cardiovascular Parameters in Alimentary Obese Children after a Month-Long Stay in Children’s Treatment Center

Childhood and adolescent obesity has become an important public health issue, as it leads to higher risk of cardio–metabolic, orthopedic, and psychological comorbidities. The aim of this study was to evaluate the changes in nutritional state and cardiovascular system parameters in obese children. Sixty respondents aged 9–17 years with alimentary obesity participated in this research. Anthropometric parameters (body weight (BWT), body mass index (BMI), percentage of body fat (%), waist and hip circumference (WC and HC), waist–hip ratio (WHR)) and cardiovascular parameters (systolic and diastolic blood pressure (SP and DP), cardio-ankle vascular index (CAVI), ankle-brachial index (ABI), pulse wave velocity and its variability (PWV and PWVV), and parameters of pulse wave analysis) were measured. Every respondent went through two sets of measurements, the first (I.) after their admission to the children’s hospital and the second (II.) at the end of their one-month-long therapeutic stay. Statistically significant differences between measurements I. and II. were observed in the following parameters: BWT (p < 0.01), BMI (p < 0.01), WC (p < 0.01), HC (p < 0.01), DP (p < 0.01), PWV (p < 0.05), and ABI (p < 0.01). The results of this study show that obesity has a mostly negative impact on the cardiovascular health of affected children, with likely negative results in their adulthood.
Antisense oligonucleotides as therapeutics for the treatment of aggressive breast cancer

There are many drugs currently available for the treatment of aggressive breast cancer. These include anthracyclines, taxanes, alkylating agents, anti-metabolites, plant alkaloids, nucleoside analogues and anti-hormonal agents. Unfortunately, even armed with this impressive arsenal, there has been little ground gained in terms of disease free years or reduced mortality for what is an essentially incurable disease in the metastatic state. Clearly, we need to improve upon the therapies available for these patients. A key step toward this goal is the development of reproducible and relevant models in which newly developed drugs may be tested. This thesis outlines the characterisation of what is anticipated to be a powerful human xenograft model of aggressive breast cancer, that of the M D A 4 3 5 / L C C 6 cell line. This cell line may be grown easily in vitro, as well as an ascitic or as a solid tumour in mice. In order to have a major impact in the field of breast cancer treatment, it w i l l not suffice to develop yet another cytotoxic agent. Instead, we must turn to the newer technologies, including gene targeted therapies, which target the molecular root of the disease. This work includes the use of both free antisense oligonucleotides (ODN), as well as those formulated within a lipid carrier. These encapsulated O D N are retained in the circulation for a longer period of time, are less susceptible to the actions of nucleases, and due to pharmacokinetic and pharmacodistribution properties of the liposomal carrier, result in enhanced tumour cell uptake of the O D N .
Overview of Modulation Strategies for LLC Resonant Converter

In this article, based on the LLC resonant converter fundamental harmonic analysis model, the modulation strategies for LLC resonant converter can be categorized into the following three groups: 1) input voltage fundamental harmonic modulation; 2) resonant tank elements modulation; and 3) secondary equivalent impedance modulation. Operational principles and control diagrams for different modulation strategies are given. Comprehensive comparisons between these modulation strategies in terms of topology complexity, control complexity, and voltage gain range are presented with respect to the same system specifications. The advantages and disadvantages for each modulation strategy are summarized to provide guidance for engineers when analyzing and designing an LLC resonant converter. The hybrid modulation strategies are categorized into different groups based on the specific applications. Brief introductions of these hybrid modulation strategies are presented. Future trends regarding the modulation strategies of LLC resonant converters are presented.