Miracle-dz/UniFAR-FTUs huggingface dataset:
Helicobacter pylori regulates ILK signaling pathways to influence autophagy in gastric epithelial cells

BackgroundThe ability of Helicobacter pylori to manipulate host autophagy is an important pathogenic mechanism.ResultsWe found a negative correlation between the expression of ILK and the autophagy marker protein LC3B in H. pylori-positive human samples and in H. pylori-infected GES-1 cell lines. There was a significant accumulation of autophagosomes in ILK-knockdown GES-1 cells, and the expression levels of both LC3B and p62 were also increased. Here, we showed the activities of Rac1 and RhoA were decreased in H. pylori-infected GES-1 cells and ILK-knockdown GES-1 cells. Inhibition of Rac1 and RhoA increased LC3B levels and autophagosome formation in GES-1 cells after H. pylori infection. Simultaneously, H. pylori infection activated downstream signal molecules of Rac1 (PAK1, LIMK1 and cofilin) and RhoA (ROCK1, ROCK2 and LIMK1 and cofilin). ConclusionsOur results demonstrated that H. pylori regulated autophagy through ILK/Rac1 and ILK/RhoA signaling pathways in gastric epithelial cells.
Impacts of Severe Weather, Climate Zone, and Energy Factors on Base Realignment and Closure (BRAC)

Abstract : The Air Force is in a period of downsizing, both aircraft and personnel. In recent years, the service has cut hundreds of aircraft from its fleet and decreased military end-strength, but has not substantially reduced its infrastructure. Consequently, the cost to operate and maintain Air Force Bases is not decreasing. Mitigation methods are needed to manage the costly burden of excess infrastructure. A new Base Realignment and Closure (BRAC) round will help the Air Force reduce unnecessary infrastructure and alleviate precious resources necessary for weapon modernization and improved readiness. Cost savings through BRAC can help the Air Force achieve reduced spending and realign itself to post-war budget reductions and a constrained fiscal environment. This research analyzed new severe weather and energy factors at 62 major Air Force Bases in the United States. Adding these new factors should better account for other potential costs and savings associated with BRAC. To estimate these costs, a Monte Carlo simulation is used to forecast annual costs and account for uncertainty with tornado and hurricane risks, along with annual electricity and natural gas costs. Annual cost estimates of these four factors range from approximately $1-million to $100-million dollars. Each base is ranked in a 1-to-n list, according to the total annual cost of the four factors, from highest to lowest. The base with highest annual cost is the best candidate, according to the new proposed criteria, to be eligible for a future BRAC round. If a base is selected for closure, forecasted costs are avoided and ultimately become savings that help offset other expenses in a BRAC scenario.
Electric Vehicle Charging Equipment Design and Health and Safety Codes

2.1 Who's involved In 1991, a national consortium of automakers, equipment manufacturers, building officials, utilities and government officials began addressing issues facing electric vehicle (EV) charging. Called the National Electric Vehicle Infrastructure Working Council (IWC), the consortium began parallel efforts to develop vehicle and charging equipment using a systems approach. The outcome of their efforts was equipment and safety standards that result in equipment which uses technology to handle shock hazards and battery hydrogen off-gassing. IWC recommended these standards to the Institute of Electrical and Electronic Engineers, the National Fire Protection Association (NFPA), the American National Standards Institute, the Society of Automotive Engineers (SAE), and Underwriters Laboratories (UL).
Using Smiles, Frowns, and Gaze to Attribute Conscious States to Others: Testing Part of the Attention Schema Theory

In the attention schema theory, people attribute the property of consciousness to themselves and others because it serves as a schematic model of attention. Most of the existing literature on monitoring the attention of others assumes that people primarily use the gaze direction of others. In that assumption, attention is not represented by a deeper model, but instead limited mainly to a single, externally visible parameter. Here we presented subjects with two cues about the attentional state of a face: direction of gaze and emotional expression. We tested whether people relied predominantly on one cue, the other, or both when deciding if the face was conscious of a nearby object. If the traditional view is correct, then the gaze cue should dominate. Instead, some people relied on gaze, some on expression, and some on an integration of cues, suggesting that a variety of surface strategies could inform a deeper model. We also assessed people’s social cognitive ability using two, independent, standard tests. If the traditional view of attention monitoring is correct, then the degree to which people use gaze to judge attention should correlate best with their social cognitive ability. Instead, social cognitive ability correlated best with the degree to which people successfully integrated the cues together. The results strongly suggest that when people attribute a specific state of consciousness to another, rather than simply tracking gaze, they construct a model of attention, or an attention schema, that is informed by a combination of surface cues.
Design of a Test Fixture for Rotational Core Losses in Electrical Machine Laminations

In recent years, several methods and devices have been proposed to measure rotational core losses. Technically, it is still a challenge to realize both high and uniform magnetic flux density within a wide area of the sample under test. Because of that, importance has been placed on the development of magnetizing circuits which are capable of performing 2-D rotating field tests. In this work, a novel design of a magnetizing circuit is presented, simulated, and implemented practically to obtain a uniform rotating flux density inside the test sample. This magnetizing circuit is based on an electromagnetic Halbach array. The new test fixture is suitable for the measurement of rotational core loss, and capable of measuring pulsating loss in different directions within the specimen. Measurements were carried out on five silicon steel circular samples of 20 cm diameter. Theses samples are: M15 gauge 29, M19 gauge 29, M19 gauge 24, M36 gauge 29, and M36 gauge 26. This work describes the influence of different flux patterns on core loss estimation, where three different machines, induction, BLDCM, and SRM are simulated to calculate the zones of rotating flux density in the stator cores of these machines. Experimental tests are executed, and the percentage error made by assuming all flux is pulsating is calculated. Core loss differences in electrical machine laminations have been noticed under rotating field in the case of clockwise (CW) and counterclockwise (CCW) direction excitation. Experimental results manifest that the anisotropy of the magnetic material is attributed mainly to the asymmetry in the CW and CCW rotational core losses, where the permeability varies significantly when the direction of rotating field is reversed. A study on three different types of machines at different frequencies show the importance of considering the direction of rotating field during the machine efficiency estimation. The negative power in rotational core loss which was reported in some laboratories has been addressed and interpreted according to the dynamic hysteresis loop behavior. The negative power which appears in one loss component is caused by the reversal of the field direction which can be realized from the interfered dynamic hysteresis loop, while the negative value in the total rotational loss originates in the sensors misalignment. The reason behind the unusual shape of the hysteresis loop under rotating field observed in the literature is revealed, where the harmonics under rotating field is responsible for the change in the hysteresis loop shape from the well known shape under pulsating field. The results show also that the behavior of the minor loop under rotating fields differs from its behavior under pulsating fields. The minor loop under rotating fields moves outside the major loop at saturation, while it is confined inside the major loop under pulsating fields. The effect of harmonics on core losses under a rotating field is estimated and compared with losses under pulsating fields.
A Landscape Architect’s Review of Building Information Modeling Technology

© 2 0 1 1 b y th e B oa rd o f R eg en ts o f th e U ni ve rs ity o f W is co ns in S ys te m GIS functionality to the scale of the building and its many components by providing highly accurate information in a computer aided drafting environment. A key component of BIM technology is the 3D parametric object. Parametric objects have parameters and rules that determine the object’s geometry, features, and properties. These parameters and rules allow the objects to automatically update based upon user control or changing events (Eastman 2008). Parametric objects are also linked, and when an object is changed in plan view, sections, details, and 3D views are automatically updated. As a result, reports (for example, bill of materials, schedules) and specifi cations can be automated within the model. Since BIM models are constructed of quantifi able and measurable components, it is easy to generate LEED compatibility and energy analysis reports, and construction documents. BIM has the potential to revolutionize the accountability of designs. As owners, clients, and decision makers require the quantifi cation of design choices, BIM can help stakeholders make informed decisions between two equally desirable designs. BIM can also eliminate ineffi ciencies in the design and construction process. Working with a central fi le allows for realtime updates of information so every consultant is working with current information. Automated construction documentation and centralized fi le repositories have saved time and money by reducing change orders (Eastman 2008). Autodesk has established itself as a leader in the CAD and BIM industry within the United States. Autodesk’s Revit software has been tailored to the needs of the disciplines of Architecture, Structure, and Mechanical, Electrical, and Plumbing. To increase functionality, Revit easily imports many CAD fi le formats into a Revit building model. Within the fi rst few minutes of using Revit it is apparent that the software is incompatible with the workfl ow of landscape architects. Most noticeable is the lack of an effi cient means to grade a site. To grade a site it is necessary to use Autodesk Civil 3D and Revit Architecture; the grading must be completed in Autodesk Civil 3D, then imported as a 3D CAD fi le into Revit Architecture to create a surface. It is then necessary to subdivide different surface materials into distinct subregions to create a site model that is defi ned by individual parametric objects (for example, road, sidewalk, turf, etc). This process is very time consuming and pushes a Windows x64 system to the limit of its processing power. A Landscape Architect’s Review of Building Information Modeling Technology
Climate as the Great Equalizer of Continental‐Scale Erosion

Central Asia hosts the most extensive and highest topography on Earth, which is the result of the feedbacks among rock uplift, atmospheric circulation and moisture transport, and erosion. Here, we analyze 2,511 published low‐temperature thermochronometric ages as a proxy of the regional‐scale erosion of Central Asia. We compare these ages to tectonic and climate proxies, and state‐of‐the‐art paleoclimate simulations to constrain the inﬂuences of climate and tectonics on the topographic architecture of Central Asia. We observe a ﬁrst‐order relationship between younger cooling ages in areas of high precipitation and older ages (Mesozoic) in areas that have been sheltered from precipitation, despite high strain rates. Thus, we suggest that climate enhances erosion in areas where rock uplift produces signiﬁcant orographic gradients, whereas in the continental interior, areas which are tectonically active but have been sheltered from signiﬁcant precipitation record older ages and a longer erosional history.
MOVING MERGE--A NEW CONCEPT IN RAMP CONTROL

MOVING MERGE CONTROL SYSTEMS ARE DEVICES INSTALLED ON FREEWAY ENTRANCE RAMPS TO HELP DRIVERS ENTER A FREEWAY FOR THOSE SITUATIONS WHERE THEY WOULD OTHERWISE HAVE DIFFICULTY IN DETERMINING ADEQUATE SIZE FREEWAY GAPS. IN THE MOVING MODE SYSTEM ACCEPTABLE GAPS IN THE RIGHT LANE OF THE FREEWAY LANE, THOSE WHICH WILL PERMIT SAFE MERGING, ARE SHOWN AS MOVING BANDS OF GREEN LIGHTS IN THE RAMPSIDE DISPLAY. BY DRIVING BESIDE ONE OF THESE BANDS A RAMP VEHICLE WILL BE PLACED IN THE PROPER RAMP MERGING POSITION FOR ENTERING A SAFE AVAILABLE GAP. IN THE STOPPED MODE OPERATION, RAMP VEHICLES ARE REQUIRED TO STOP AT A TRAFFIC SIGNAL LOCATED ON THE RAMP SHOULDER. VEHICLE DETECTORS IN THE RIGHT LANE OF THE FREEWAY ARE USED TO SEARCH FOR GAPS WHICH WILL PERMIT SAFE MERGING AND THE TRAFFIC SIGNAL IS TURNED GREEN AT THE PROPER TIME.
Human-centered aircraft automation: A concept and guidelines

Aircraft automation is examined and its effects on flight crews. Generic guidelines are proposed for the design and use of automation in transport aircraft, in the hope of stimulating increased and more effective dialogue among designers of automated cockpits, purchasers of automated aircraft, and the pilots who must fly those aircraft in line operations. The goal is to explore the means whereby automation may be a maximally effective tool or resource for pilots without compromising human authority and with an increase in system safety. After definition of the domain of the aircraft pilot and brief discussion of the history of aircraft automation, a concept of human centered automation is presented and discussed. Automated devices are categorized as a control automation, information automation, and management automation. The environment and context of aircraft automation are then considered, followed by thoughts on the likely future of automation of that category.
Ascertaining the UX of the Word Mania Mobile App for Children using Fun Toolkit v3

A user experience evaluation was carried on Word Mania mobile app. Word Mania is fun educational games app for children. Fun Tookit v3, a survey instrument developed to assist researchers in acquiring the opinions about technology (web or app) from children was used for data capture. The purpose of the toolkit is to generate the perception of kids as young as 4 years old who had some experience when interacting with an implementation. The Fun Toolkit v3 tool consists of three components that can be used on applications, websites or technology products to "pass opinions. " These three sections are: Smileyometer, Fun Sorter, Again and Again.At UUM International School, Sintok, Malaysia, this assessment study was performed with students. The survey was attended by a total of 12 students. The evaluation questionnaires were filled out with the help of their teachers by the participating children.The findings stated that the mobile application was adopted by the kids; however, some problems had to pay attention in order to enhance the children's user experience.Special exercises should be found for children aged one or two years because current exercises are difficult for these ages. Competition task is not an simple task, particularly for kids aged 3 to 4 years. Children between the ages of 5 and 6 need more time to complete the tasks, for these ages three minutes are not enough
Characterization and modelling of SFRC elements

The use of fibre reinforced concrete (FRC) as a construction material has expanded beyond the traditional applications since the publication of design codes and guidelines. In fact, the industry is demanding FRC with increasing structural responsibilities and, in some cases, with the fibres as the only reinforcement. Despite the remarkable advances in the fibre reinforcement technology and the publication of design guidelines, questions continue to arise regarding the performance, the characterization and the modelling of the material. The definition of the constitutive model of FRC and the development of methods for the characterization have been extensively studied. However, their adequacy for certain applications still remains an issue. Moreover, properties such as the fibre orientation and the creep behaviour are not minor concerns and need to be properly considered. These subjects require further research in order to work towards an accurate and efficient design procedure. In this context, the great interest of the industry to understand better FRC behaviour has created the opportunity of performing small-scale and real-scale tests that are a valuable source of information. Therefore, a rather generalist doctoral thesis covering several subjects about the characterization and modelling of steel fibre reinforced concrete (SFRC) elements is proposed. The subjects addressed in this research refer to the flexural behaviour and modelling of RC-SFRC beams (beams with combined reinforcement of steel fibres and rebars); the flexural behaviour, fibre orientation and modelling of SFRC slabs with changing dimensions; the prediction of the tensile behaviour of SFRC and the post-cracking creep behaviour of SFRC. The first subject concerns the adequacy of the constitutive models proposed in the current European codes and guidelines to model the flexural response of RC-SFRC beams. For that, real-scale elements with different steel fibres and fibre contents were tested. The results of the numerical modelling show that, in general, these constitutive models reproduce satisfactorily the experimental data. In the second subject, based on the flexural behaviour of real-scale SFRC slabs, geometry factors are proposed to compensate for the inaccuracies of the current constitutive models to reproduce the response of such elements. The study conducted on the modelling of the flexural behaviour of the slabs allowed identifying a favourable effect of the fibre orientation (fibre network effect) as the width of the slabs increased. The third subject covers a proposal of an analytical formulation to estimate the tensile stress-strain diagram of FRC from the results of the Barcelona test. The validation performed indicates the applicability of the new model to concrete with either steel fibres or plastic fibres. The last subject focuses on the post-cracking creep behaviour of SFRC, which is assessed by performing flexural tests under sustained load on pre-cracked small-scale beams. Based on the results, a simple model to predict the evolution of the creep coefficient with time is proposed.
Advanced Boost-up in Hino EP100-II Turbocharged and Charge-Cooled Diesel Engine

Hino Motors, Ltd. has added to its line of charge-cooled engines for heavy duty trucks a higher power version which is called EP100-II. To meet the recent customers' demands for rapid transportation with better fuel economy, this engine was developed on the uprating program for the original EP100 which was introduced in 1981 as the first Japanese turbo-charged and air to air charge-cooled engine. EP100-II has the same displacement as the original EP100, 8.8 liters, and is an in-line six cylinder engine with 228 kW(310PS)/2,100 rpm (JIS) output that provides the world's utmost level specific output of 25.8 kW (35.1PS)/liter. Also this engine achieved a maximum BMEP of 16.8 bar/1,300 rpm and best BSFC of 199 gr/kWh at 1,500 rpm. This paper describes the advanced technology for increasing horsepower and improving fuel consumption.
The Succession Challenge: Building and Sustaining Leadership Capacity Through Succession Management

Foreword - Andy Hargreaves Warm Bodies or Leaders of Learning The Succession Challenge: Supply and Demands The Succession Challenge in Time and Space The Succession Challenge up Close - Andy Hargreaves, Corrie Giles and Shawn Moore The Succession Challenge up Really Close Pipelines, Pools and Reservoirs The Good, the Bad and the Ugly Succeeding Leaders
Trajectory optimization for helicopter Unmanned Aerial Vehicles (UAVs)

Abstract : This thesis explores the numerical methods and software development for optimal trajectories of a specific model of Helicopter Unmanned Aerial Vehicle (UAV) in an obstacle-rich environment. This particular model is adopted from the UAV Laboratory of the National University of Singapore who built and simulated flights for an X-Cell 60 small-scale UAV Helicopter. The code, which allowed the team to simulate flights, is a complex system of non-linear differential equations-15 state variables and four control variables-used to maneuver the state trajectories. This non-linear model is incorporated into a separate optimization algorithm code, which allows the user to set initial and final time conditions together with various constraints, and, using the same variable scheme, optimize a trajectory. The optimal trajectory is defined by using a cost function-the performance measure-and the system is subject to a set of constraints (such as mechanical limitations and physical three-dimensional obstacles). Simulations conclude that solutions are readily obtained; however, it is still very difficult to derive trajectories that are truly optimal, and our work calls for more future research in computational programs for optimal trajectory planning. All simulations in this thesis are modeled using the MATLAB program.
Plans

Communities have been planning for disasters for a very long time, especially for natural disasters. The capability to predict when the hurricane will hit a coastal area or island is available. Precautions are reported to the public, and preparedness activities are posted continuously. Planning for cyber incidents is a much newer activity, and it has been getting increasingly more sophisticated as time goes on. A community plans for physical events such as a hurricane, flood, or tornado because they are in geographic areas that are prone to these threats. All communities need to prepare for a cyber incident or attack. In the early 2000s, the CIAS would hear comments such as “Our county is too small” or “No one would target us, we don't have anything they would want. ” No matter how small the organization and no matter what the size of the community, everyone is a target today. Preparing for “when” the cyber incident happens is the best approach, and that means every municipality, county, and parish should have a plan in place to continue business and to respond to an incident.
A new method for optimal output of a solar cell array

A new method for optimizing the output of a solar cell array is presented. Several curves printed under different solar radiation levels and temperatures is given out. It is confirmed by an experimental setup that introducing this output control method, compared with using the traditional charging method, can obtain notably more power from the same solar cell array. <<ETX>>
E-Learning Applications in the EELA Project

The EELA Project was created with the aim of supporting the increasing demand for Grid Infrastructures to foster the collaboration among groups of Latin America and Europe. As a starting point, several applications have been selected in four scientific fields. One of the most important areas among them is e-Learning due to its high impact and significance in the Latin America society. Newly applications are being developed by several groups from Latin America participating in the project. This article will shortly describe the EELA project itself and the current status and aims of the six e-Learning applications to be deployed.