Miracle-dz/UniFAR-FTUs huggingface dataset:
Fostering Creativity in Intercultural and Interdisciplinary Teams: The VICTORY Model

Teams are pervasive in the history of mankind. Particularly in our fast-growing modern society, teams composed of members from different cultures and disciplines are quite often used at the workplace. Though widely used, the effectiveness of teams is inconsistent. Meta-analyses report a double-edged effect of diversity on creativity and innovation, suggesting that diversity needs to be tactfully managed if we want to leverage the creative potential of teams. The current paper strives to meet this challenge and makes recommendations on how to foster creativity in intercultural and interdisciplinary teams. It discusses the concepts of teams vs. groups and creativity vs. innovation. Drawing upon sociocultural theories of creativity and innovation, particularly literature reviews and meta-analyses, this paper attempts to identify non-cognitive, cognitive and environmental enablers of team creativity. The VICTORY model offers a summary of these enablers, as it focuses on team (T) and synthesizes both non-cognitive (Vision, Openness, Risk-taking, Yes-I-Can Mindset) and cognitive (Ideation, Combination) antecedents of team creativity. Yet it is only through the combination and integration of environmental factors (including communication, collaboration, and support, among others) that the effect of these antecedents can be fully realized.
Activation of p53 Gene Expression and Synergistic Antiproliferative Effects of 5-Fluorouracil and β-escin on MCF7 Cells

One of the most common malignancies in women is breast cancer. β-escin has pharmacological anticancer effects. 5-fluorouracil (5-FU) has antimetabolite and antiproliferative properties. The purpose of this study was to investigate the combined effects of 5-FU and β-escin on apoptosis, colony formation, Bcl-2 signaling protein, and p53 gene expression in MCF7 breast cancer cell line. The cytotoxic effects, the number of colonies, apoptosis, p53 gene expression, and Bcl-2 signaling protein of the combined 5-FU and β-escin on MCF7 cells were determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, clonogenic assay, flow cytometry, real-time quantitative polymerase chain reaction, and western blotting methods, respectively. Half-maximal inhibitory concentration values of β-escin and 5-FU were 80 μg/ml and 2 μM, respectively. The combination of 5-FU and β-escin on MCF7 cell viability showed a combination index equal to 0.5. The expression of p53 and apoptosis increased in the combination of 5-FU and β-escin on MCF7 cells compared to that of control group (P < 0.05). In addition, the number of colonies and Bcl-2 signaling protein in combination of 5-FU and β-escin decreased with respect to untreated control cells or single treatment of 5-FU and β-escin. The combination of 5-FU and β-escin not only has synergistic effects by increasing cell apoptosis and p53 gene expression but also decreases Bcl-2 signaling protein in MCF7 cell lines.
Role of artificial intelligence and machine learning in ophthalmology

Artificial intelligence (AI) and machine learning (ML) have entered several avenues of modern life, and health care is just one of them. Ophthalmology is a field with a lot of imaging and measurable data, thus ideal for application of AI and ML. Many of these are still in research stage, but show promising results. The ophthalmic diseases where AI is being used are diabetic retinopathy, glaucoma, age-related macular degeneration, retinopathy of prematurity, retinal vascular occlusions, keratoconus, cataract, refractive errors, retinal detachment, squint, and ocular cancers. It is also useful for intraocular lens power calculation, planning squint surgeries, and planning intravitreal antivascular endothelial growth factor injections. In addition, AI can detect cognitive impairment, dementia, Alzheimer's disease, stroke risk, and so on from fundus photographs and optical coherence tomography. We will surely see many more innovations in this rapidly growing field.
Numerical Simulation and Mathematical Modeling of Electro-Osmotic Couette-Poiseuille Flow of MHD Power-Law Nanofluid with Entropy Generation

The basic motivation of this investigation is to develop an innovative mathematical model for electro-osmotic flow of Couette–Poiseuille nanofluids. The power-law model is treated as the base fluid suspended with nano-sized particles of aluminum oxide (Al2O3). The uniform speed of the upper wall in the axial path generates flow, whereas the lower wall is kept fixed. An analytic solution for nonlinear flow dynamics is obtained. The ramifications of entropy generation, magnetic field, and a constant pressure gradient are appraised. Moreover, the physical features of most noteworthy substantial factors such as the electro-osmotic parameter, magnetic parameter, power law fluid parameter, skin friction, Nusselt number, Brinkman number, volume fraction, and concentration are adequately delineated through various graphs and tables. The convergence analysis of the obtained solutions has been discussed explicitly. Recurrence formulae in each case are also presented.
An ASP-based framework for operating room scheduling

The Operating Room Scheduling (ORS) problem is the task of assigning patients to operating rooms, taking into account different specialties, the surgery and operating room session durations, and different priorities. Given that Answer Set Programming (ASP) has been recently employed for solving real-life scheduling and planning problems, in this paper we ﬁrst present an off-line solution based on ASP for solving the ORS problem. Then, we present techniques for re-scheduling on-line in case the off-line schedule can not be fully applied. Results of an experimental analysis conducted on benchmarks with realistic sizes and parameters show that ASP is a suitable solving methodology also for the ORS problem. This analysis has been performed with a web framework for managing ORS problems via ASP that allows a user to insert the main parameters of the problem, solve a speciﬁc instance, and show results graphically in real-time.
Dry Eye Analysis: A Citation Network Study

Introduction Dry eye is one of the most frequent eye problems with prevalence and incidence from 5% to 50%. Citation network analysis allows us to simplify information in a visual way and provides a better understanding of the research done in a specific field. The objective of this paper is to quantify and analyse the relationships among the scientific literature in this field using citation network analysis. Materials and Methods The program used to analyse the citations was CitNetExplorer®. Previously, papers published in the research field during a predefined period were found using the keywords defined in Web of ScienceTM (WOS). Results Using the keyword “dry eye,” during the period 2007 to 2018, the most cited paper is by Lemp, MA (2007), with a citation index score of 913 in our citation network containing 6,500 most relevant papers. Analysing clustering, we found 5 relevant groups that match the main areas of research in this field: definition and classification, treatment, retina, refractive surgery, and quality of vision. Core Publication is composed of 64% of the papers in the network, which is a high percentage. It indicates a clear focus on the research carried out in this field. Conclusions This citation network analysis shows definition and classification of dry eye to be the most researched area in this field, followed by treatment.
Elektrochemische Kinetik

Der umfangreichste Beitrag zu diesem Band, aus der Feder von B. Lax und J. G. Mavroides, befaßt sich mit Zyklotron-Resonanzen. Er geht aus von den Zyklotronresonanzen freier Elektronen und Ionen imd behandelt dann sehr ausführlich die Zyklotron-Resonanzen in Halbleitern und Metallen. Dieser Artikel wird der Theorie und den Experimenten in gleicher Weise gerecht und gibt nicht nur eine ausgezeichnete Zusammenfassung der vorliegenden Ergebnisse, sondern auch einen Uberblick über die Möglichkeiten zukünftiger Experimente. Ein Artikel mittlerer Länge von R. W. Keyes behandelt den Einfluß elastischer Verzerrungen auf den elektrischen Widerstand von Halbleitern, wobei insbesondere der Zusammenhang mit der Bandstruktur besprochen wird. Zwei kürzere Beiträge von je 40 Seiten befassen sich mit speziellen Materialien, nämlich mit den Halbleitereigenschaften von grauem Zinn (G. B. Busch und R. Kern) und mit der photoelektrischen Untersuchung von Ionisationsenergien von Fehlstellen in Kristallen des CdS-Typs (R. H. Buhl). C. A. Swenson berichtet über die Physik bei hoben Drucken, wobei besonders die Fortsehritte in der experimentellen Methodik (vor allem auch in Verbindung mit tiefen Temperaturen) beschrieben werden. Der den Anwendungen gewidmete Teil enthält nahezu 400 Zitate neuerer Arbeiten, wobei allerdings der einzelnen Arbeit oft nicht mehr als ein bis zwei Sätze gewidmet werden konnten. Als Bibliographie dürfte jedoch auch dieser Teil recht nützlich sein. A. Seeger, Stuttgart
Spektroskopische Untersuchungen an organometallischen Verbindungen VIII

Es werden die IR-Spektren zwischen 4000 und 250/cm sowie die Absorptionsspektren im sichtbaren und ultravioletten Bereich von einigen jr-Komplexen von C4X4 (X = — CH3 und — C6H5) angegeben. Verschiedene analytisch bedeutsame Komplexbanden werden aufgezeigt. Für die 4 untersuchten Tetraphenyl-cyclobutadien-Komplexe kann diese Struktur aus dem IR-Spektrum durch Vergleich mit C4 (C6H5)4Fe(CO)3 gesichert werden.
Ultra-Mutation in IDH Wild-Type Glioblastomas of Patients Younger than 55 Years is Associated with Defective Mismatch Repair, Microsatellite Instability, and Giant Cell Enrichment

Background: Glioblastomas (GBMs) are classified into isocitrate dehydrogenase (IDH) mutants and IDH wild-types (IDH-wt). This study aimed at identifying the mutational assets of IDH-wt GBMs in patients aged 18–54 years for which limited data are available. Methods: Sixteen IDH-wt GBMs from adults < 55 years old were explored for mutations, copy number variations, tumour mutational load (TML), and mutational spectrum by a 409 genes TML panel. Results: Eight (50%) IDH-wt GBMs were hypermutated (TML > 9 mutations/Mb) and two (12.5%) were ultra-mutated (TML > 100 mutations/Mb). One ultra-mutated GBM had microsatellite instability (MSI), a somatic MSH6 mutation, and a germline POLE mutation. The other ultra-mutated GBMs had MSI and two somatic mutations in MSH2. Both ultra-mutated GBMs featured at least 25% giant cells. The overall survival of eight patients with hypermutated GBMs was significantly longer than that of patients with non-hypermutated GBMs (p = 0.04). Conclusions: We identified a hyper-mutated subgroup among IDH-wt GBMs in adults < 55 years that had improved prognosis. Two cases were ultra-mutated and characterized by the presence of at least 25% giant cells, MMR mutations, and MSI. Since high TML has been associated with response to immune checkpoint inhibition in paediatric gliomas, the identification of a subtype of ultra-mutated IDH-wt GBM may have implications for immunotherapy.
Apolipoprotein L1 Testing in African Americans: Involving the Community in Policy Discussions

Background: Apolipoprotein A1 (APOL1) gene variants occurring in people of West African descent contribute to the greater burden of kidney disease among African Americans. These variants are associated with increased risk of nondiabetic nephropathy, more rapid progression of chronic kidney disease, and shorter survival of donor kidneys after transplantation. However, only a minority of people with APOL1-associated risk develops kidney disease and specific clinical measures to address APOL1-associated risk are lacking. Given these uncertainties, we sought to engage members of the African American public in discussions with other stakeholders about the appropriate use of APOL1 testing. Methods: Formative interviews with community members, researchers, and clinicians in Seattle WA, Nashville TN, and Jackson MS, provided baseline information about views toward APOL1 testing and informed the design of 3 community-based deliberations among African Americans. A national meeting held in March 2018 included 13 community members, 7 scientific advisors and 26 additional researchers, clinicians, bioethicists, patient advocates, and representatives from professional organizations and federal funding agencies. Using small break-out and plenary discussion, the group agreed on recommendations based on current knowledge about APOL1-associated risk. Results: Meeting outcomes included recommendations to develop educational materials about APOL1 for community members and clinicians; to offer APOL1 research results to participants; and on the use of APOL1testing in kidney transplant programs. The group recommended against the routine offer of APOL1 testing in clinical care. Areas of disagreement included whether kidney transplant programs should require APOL1 testing of prospective living donors or bar individuals with APOL1 risk from donating kidneys and whether testing should be available on request in routine clinical care. Conclusion: We recommend continued discussion among stakeholders and concerted efforts to ensure active and informed participation of members of the affected community to guide research on APOL1 and kidney disease.
Engineered Polymeric Materials for Biological Applications: Overcoming Challenges of the Bio–Nano Interface

Nanomedicine has generated significant interest as an alternative to conventional cancer therapy due to the ability for nanoparticles to tune cargo release. However, while nanoparticle technology has promised significant benefit, there are still limited examples of nanoparticles in clinical practice. The low translational success of nanoparticle research is due to the series of biological roadblocks that nanoparticles must migrate to be effective, including blood and plasma interactions, clearance, extravasation, and tumor penetration, through to cellular targeting, internalization, and endosomal escape. It is important to consider these roadblocks holistically in order to design more effective delivery systems. This perspective will discuss how nanoparticles can be designed to migrate each of these biological challenges and thus improve nanoparticle delivery systems in the future. In this review, we have limited the literature discussed to studies investigating the impact of polymer nanoparticle structure or composition on therapeutic delivery and associated advancements. The focus of this review is to highlight the impact of nanoparticle characteristics on the interaction with different biological barriers. More specific studies/reviews have been referenced where possible.
When colours split from objects: The disconnection of colour perception from colour language and colour knowledge

ABSTRACT We investigated object-colour knowledge in RDS, a patient with impaired colour naming after a left occipito-temporal stroke. RDS’s colour perception, object naming and verbal colour-knowledge (the ability to verbally say the typical colour of an object) were relatively spared. RDS was also able to state if an object was appropriately coloured or not. However, he could neither match colour names to coloured objects, nor match colour patches to grey-scale objects. Thus, RDS’s colour-naming deficit was associated with an impaired ability to conceptually relate visually presented object shapes and colours. These results suggest that objects in their typical colour are processed holistically in the visual modality, and that abilities important for colour naming may also be involved in abstracting colours from visual objects. We discuss these findings in the context of developmental psychology and linguistic anthropology, and propose a model of neuro-functional organization of object-colour knowledge.
The Efficacy of Device Designs (Mono-block or Bi-block) in Oral Appliance Therapy for Obstructive Sleep Apnea Patients: A Systematic Review and Meta-Analysis

Oral appliance (OAm) therapy has demonstrated efficacy in treating obstructive sleep apnea (OSA). The aim of this systematic review was to clarify the efficacy of device designs (Mono-block or Bi-block) in OAm therapy for OSA patients. We performed a meta-analysis using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system. Two studies (Mono-block OAm versus Bi-block OAm) remained eligible after applying the exclusion criteria. When comparing Mono-block OAm and Bi-block OAm, Mono-block OAm significantly reduced the apnea–hypopnea index (2.92; 95% confidence interval (95%CI), 1.26 to 4.58; p = 0.0006), and patient preference for Mono-block OAm was significantly higher (2.06; 95%CI, 1.44 to 2.06; p < 0.0001). Lowest SpO2, arousal index, non-REM stage 3, sleep efficiency, Epworth Sleepiness Scale (ESS), Snoring Scale, and side effects were not significantly different between the two groups (lowest SpO2: −11.18; 95%CI, −26.90 to 4.54; p = 0.16, arousal index: 4.40; 95%CI, −6.00 to 14.80; p = 0.41, non-REM stage 3: −2.00; 95%CI, −6.00 to 14.80; p = 0.41, sleep efficiency: −1.42, 95%CI, −4.71 to 1.86; p = 0.40, ESS: 0.12; 95%CI, −1.55 to 1.79; p = 0.89, Snoring Scale: 0.55; 95%CI, −0.73 to 1.83, p = 0.55, side effects: 1.00, 95%CI, 0.62 to 1.61, p = 1.00). In this systematic review, the use of Mono-block OAm was more effective than Bi-block OAm for OSA patients.
Independent evolution of rosmarinic acid biosynthesis in two sister families under the Lamiids clade of flowering plants

As a means to maintain their sessile lifestyle amid challenging environments, plants produce an enormous diversity of compounds as chemical defenses against biotic and abiotic insults. The underpinning metabolic pathways that support the biosynthesis of these specialized chemicals in divergent plant species provide a rich arena for understanding the molecular evolution of complex metabolic traits. Rosmarinic acid (RA) is a phenolic natural product first discovered in plants of the mint family (Lamiaceae) and is recognized for its wide range of medicinal properties and potential applications in human dietary and medical interventions. Interestingly, the RA chemotype is present sporadically in multiple taxa of flowering plants as well as some hornworts and ferns, prompting the question whether its biosynthesis arose independently across different lineages. Here we report the elucidation of the RA biosynthetic pathway in Phacelia campanularia (desert bells). This species represents the borage family (Boraginaceae), an RA-producing family closely related to the Lamiaceae within the Lamiids clade. Using a multi-omics approach in combination with functional characterization of candidate genes both in vitro and in vivo, we found that RA biosynthesis in P. campanularia involves specific activities of a BAHD acyltransferase and two cytochrome P450 hydroxylases. Further phylogenetic and comparative structure–function analyses of the P. campanularia RA biosynthetic enzymes clearly indicate that RA biosynthesis has evolved independently at least twice in the Lamiids, an exemplary case of chemotypic convergence through disparate evolutionary trajectories.
Moderate Cardiovascular Exercise Speeds Up Neural Markers of Stimulus Evaluation During Attentional Control Processes

Moderate intensity cardiovascular exercise appears to provide a low-cost “intervention” on neurocognitive processes such as attentional control, yet the effects vary depending, for example, on cognitive task, time of testing, or exercise intensity. However, while a number of studies show that brief bouts of acute exercise can modulate behavioral indices of cognitive control, relatively few studies have attempted to identify the brain activity associated with these changes immediately following exercise. Here, we tested 11 young adults in a crossover design with a Flanker task at rest and immediately (within 2–3 min) following 20 min of acute exercise at 60% of the individual VO2max. In order to prevent delayed exercise effects that might confound or dilute immediate effects, a short version of the Flanker task (8 min) was chosen and an EEG was recorded simultaneously. The N2 and P3 ERP components were analyzed in addition to accuracy and response time. The N2 reflects conflict resolution, and the P3 has been linked to stimulus evaluation processes. No effect of exercise was found for behavioral data but P3 peak latencies were shorter following exercise as compared to rest. The N2 amplitude data suggest that exercise seems to prevent a decline in resources of attentional control over time. These data indicate that acute exercise, at a moderate intensity level, speeds up neural processing of attentional control by modulating stimulus evaluation processes immediately following exercise and that exercise helps maintain a steady level of neurocognitive resources.
Draft assembly of Phytopthora capsici from long-read sequencing uncovers complexity.

Resolving complex plant pathogen genomes is important for identifying the genomic shifts associated with rapid adaptation to selective agents such as host and fungicide, yet assembling these genomes remains challenging and expensive. Phytophthora capsici is an important, globally distributed plant pathogen that exhibits wide-spread fungicide resistance and a broad host range. As with other pathogenic oomycetes, P. capsici has a complex life history and a complex genome. Here we leverage Oxford Nanopore Technology (ONT) and existing short read resources, to rapidly generate a low-cost, improved assembly. We generated 10Gbp from a single MinIon flow cell resulting in > 1.25 million reads with an N50 of 13kb. The resulting assembly is 124Mbp in 906 scaffolds with an N50 length of 232kb. This assembly is 92% bigger than the current draft genome of 64Mbp. We confirmed this larger genome size using flow cytometry, with an estimated size of 110Mbp. BUSCO analysis identified 96.5% complete orthologs (39.7% duplicated). Evolutionary analysis supports a recent whole genome duplication in this group. Our work provides a blueprint for rapidly integrating benchtop long-read sequencing with existing short-read data, to dramatically improve assembly quality and integrity of complex genomes and offer novel insights into pathogen genome function and evolution.
Measurement of listening effort using of a dual-task paradigm of Brazilian Portuguese: a pilot study

Accepted: January 07, 2019 Study conducted at Departamento de Fonoaudiologia, Faculdade de Filosofia e Ciências, Universidade Estadual Paulista “Júlio de Mesquita Filho” – UNESP Marília (SP), Brasil. 1 Faculdade de Filosofia e Ciências, Universidade Estadual Paulista “Júlio de Mesquita Filho” – UNESP Marília (SP), Brasil. 2 Escola Paulista de Medicina – EPM, Universidade Federal de São Paulo – UNIFESP São Paulo (SP), Brasil. Financial support: nothing to declare. Conflict of interests: nothing to declare. ABSTRACT