Miracle-dz/UniFAR-FTUs huggingface dataset:
m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

mRNA modification regulates pluripotency When stem cells progress from an embryonic pluripotent state toward a particular lineage, molecular switches dismantle the transcription factor network that keeps the cell pluripotent. Geula et al. now show that N6-methyladenosine (m6A), a messenger RNA (mRNA) modification present on transcripts of pluripotency factors, drives this transition. Methylation destabilized mRNA transcripts and limited their translation efficiency, which promoted the timely decay of naïve pluripotency. This m6A methylation was also critical for mammalian development. Science, this issue p. 1002 A messenger RNA epigenetic modification regulates stem cell progression from the pluripotent to the differentiated state. Naïve and primed pluripotent states retain distinct molecular properties, yet limited knowledge exists on how their state transitions are regulated. Here, we identify Mettl3, an N6-methyladenosine (m6A) transferase, as a regulator for terminating murine naïve pluripotency. Mettl3 knockout preimplantation epiblasts and naïve embryonic stem cells are depleted for m6A in mRNAs, yet are viable. However, they fail to adequately terminate their naïve state and, subsequently, undergo aberrant and restricted lineage priming at the postimplantation stage, which leads to early embryonic lethality. m6A predominantly and directly reduces mRNA stability, including that of key naïve pluripotency-promoting transcripts. This study highlights a critical role for an mRNA epigenetic modification in vivo and identifies regulatory modules that functionally influence naïve and primed pluripotency in an opposing manner.
Violence in Adulthood and Mental Health

The aim of this study was to describe perceived abuse in adult Spanish and Ecuadorian women and men and to assess its association with mental health. A population-based survey was conducted in Spain in 2006. Data were taken from a probabilistic sample allowing for an equal number of men and women, Spaniards and Ecuadorians. Mental disorder was measured with the General Health Questionnaire-28. The nine questions on exposure to physical, sexual, and psychological abuse during the previous year were self-administered. Multivariate logistic regression was used to assess the association between exposure to abuse and poor mental health, adjusting for potential confounders. The sample was composed of 1,059 individuals aged 18 to 54, 104 of whom reported physical, psychological, or sexual abuse. Some 6% refused to answer the questions on abuse. Overall, reported abuse ranged from 13% in Ecuadorian women to 5% in Spanish men. Psychological abuse was the most frequent. Half the abused women, both Spanish and Ecuadorian, reported intimate partner violence (IPV), as did 22% of abused men. Poor mental health was found in 61% of abused Spanish women (adjusted Odds Ratio [ORa] = 5.1; 95% CI: 1.8-14.4), and 62% abused Ecuadorian women (ORa = 4; 95% CI: 2-7.9), in 36% of abused Spanish men (ORa = 3; 95% CI: 0.9-10.7) and in 30% abused Ecuadorian men (ORa = 2.8; 95% CI: 1-7.7). Interpersonal violence is frequent in relations with the partner, the family, and outside the family, and it seriously affects the mental health. Ecuadorian women stand out as the most vulnerable group.
A New Minimum Exposure Path Problem and Its Solving Algorithm

The original minimum exposure path (MEP) problem in wireless sensor networks (WSN) does not take into account the actual constraint conditions of the path. This paper proposes a new MEP problem which requires the path must lie along some border of a protected area. As unable to set up the corresponding weight graph model, the original classic method (grid-based method) in solving the original MEP problem does not work for the proposed MEP problem anymore. We first convert it into a continuous optimization problem, and then design a genetic algorithm to solve this complex optimal problem. The simulation test shows that the design optimization model and algorithm can solve the new proposed MEP problem effectively.
An Exploratory Analysis of College Students’ Response and Reporting Behavior Regarding Intimate Partner Violence Victimization and Perpetration Among Their Friends

Over the last several decades, an extensive literature has documented the prevalence of dating violence on college campuses. As a result, initiatives to promote awareness of dating violence on college campuses have proliferated and models of “bystander intervention” have been developed. Bystander intervention asserts that by giving all students information concerning the prevalence and warning signs of dating violence, these individuals will “say something” when they see problem behavior. However, a paucity of empirical research exists concerning whether students actually report their observation of dating violence among their peers. In the present study, a sample of college freshman (n = 275) was surveyed regarding their willingness to report dating violence behaviors among their friends. Findings indicate that a slight majority of respondents report that they would report dating violence victimization among their friends to university officials (54%) and/or law enforcement (56%) while fewer indicated they would report perpetration, 38% and 42%, respectively. Importantly, respondents overwhelmingly report that they would attempt to intervene in the dating violence victimization (87%) and perpetration (84%). Implications of these findings for campus safety initiatives and bystander education models are discussed.
The 1992 APON Delphi Study to Establish Research Priorities for Pediatric Oncology Nursing

From the National Institute of Nursing Research, National Institutes of Health, Bethesda, MD. The information presented by the authors reflects the opinions and work of the authors and not those of the National Institute of Nursing Research Address reprint requests to Mary Ropka, National Institute of Nursing Research, Building 31, Room 5B-03, 9000 Rockville Pike, Bethesda, MD 20892. Nursing, as a profession, is committed to the generation of knowledge for the purposes of grounding nursing practice in an evolving scientific basis; improving health; and ameliorating the effects of disease, health conditions, or injuries for individuals, families, and communities. ’ Research priority identification by specialty nursing organizations, such as the Association of Pediatric Oncology Nurses
An RGB-D Database Using Microsoft's Kinect for Windows for Face Detection

The very first step in many facial analysis systems is face detection. Though face detection has been studied for many years, there is not still a benchmark public database to be widely accepted among researchers for which both color and depth information are obtained by the same sensor. Most of the available 3d databases have already automatically or manually detected the face images and they are therefore mostly used for face recognition not detection. This paper purposes an RGB-D database containing 1581 images (and their depth counterparts) taken from 31 persons in 17 different poses and facial expressions using a Kinect device. The faces in the images are not extracted neither in the RGB images nor in the depth hereof, therefore they can be used for both detection and recognition. The proposed database has been used in a face detection algorithm which is based on the depth information of the images. The challenges and merits of the database have been highlighted through experimental results.
Optical coherence tomography in guided surgery of GI cancer

Optical Coherence Tomography (OCT) is a new high spatial resolution, real-time optical imaging modality, known from prior pilot studies for its high sensitivity to invasive cancer. We reported our results in an OCT feasibility study for accurate determination of the proximal border for esophageal carcinoma and the distal border for rectal carcinoma. The OCT study enrolled 19 patients with rectal adenocarcinoma and 24 patients with distal esophageal carcinoma (14 squamous cell carcinomas, 10 adenocarcinomas). During pre-surgery planning endoscopy we performed in vivo OCT imaging of the tumor border at four dial clock axes (12, 3, 6 and 9 o’clock). The OCT border then was marked by an electrocoagulator, or by a methylene blue tattoo. A cold biopsy (from the esophagus) was performed at visual and OCT borders and compared with visual and OCT readings. 27 post-surgery excised specimens were analyzed. OCT borders matched the histopathology in 94% cases in the rectum and 83.3% in the esophagus. In the cases of a mismatch between the OCT and histology borders, a deep tumor invasion occurred in the muscle layer (esophagus, rectum). Because of its high sensitivity to mucosal cancer, OCT can be used for pre-surgery planning and surgery guidance of the proximal border for esophageal carcinoma and the distal border for rectal carcinoma. However, deep invasion in the rectum or esophageal wall has to be controlled by alternative diagnostic modalities.
Pre-Pregnancy Dating Violence and Birth Outcomes Among Adolescent Mothers in a National Sample

Although infants born to adolescent mothers are at increased risk of adverse birth outcomes, little is known about contributors to birth outcomes in this group. Given past research linking partner abuse to adverse birth outcomes among adult mothers, we explored associations between pre-pregnancy verbal and physical dating violence and the birth weight and gestational age of infants born to adolescent mothers. Data from the National Longitudinal Study of Adolescent Health Waves I (1995/1996), II (1996), and IV (2007/2008) were analyzed. Girls whose first singleton live births occurred after Wave II interview and before age 20 (N = 558) self-reported infants’ birth weight and gestational age at Wave IV. Dating violence victimization (verbal and physical) in the 18 months prior to Wave II interview was self-reported. Controls included Wave I age, parent education, age at pregnancy, time between reporting abuse and birth, and childhood physical and sexual abuse. Weighted multivariable regression models were performed separately by race (Black/non-Black). On average, births occurred 2 years after Wave II interview. Almost one in four mothers reported verbal dating violence victimization (23.6%), and 10.1% reported physical victimization. Birth weight and prevalence of verbal dating violence victimization were significantly lower in Black compared with non-Black teen mothers. In multivariable analyses, negative associations between physical dating abuse and birth outcomes became stronger as time increased for Black mothers. For example, pre-pregnancy physical dating abuse was associated with 0.79 kilograms lower birth weight (p< .001) and 4.72 fewer weeks gestational age (p< .01) for Black mothers who gave birth 2 years post-reporting abuse. Physical dating abuse was unassociated with birth outcomes among non-Black mothers, and verbal abuse was unassociated with birth outcomes for all mothers. Reducing physical dating violence in adolescent relationships prior to pregnancy may improve Black adolescent mothers’ birth outcomes. Intervening on long-term violence may be particularly important.
Passage of bacteriophage particles through intact skin of mice.

1. This report is paper number 104, Institute of Geophysics, University of California, Los Angeles. The work was supported by grants from the National Science Foundation. 2. F. W. Kuster and E. Heberlein, Z. anorg. Chem. 43, 54 (1905). 3. F. W. Dickson and G. Tunell, Science 119, 467 (1954). 4. The value of n in moles of S at 25? C in the analyzed solutions ranged from 3.74 to 3.80, and averaged 3.77; at 50? C, n ranged from 3.60 to 4.48 and averaged 4.03.
The Shapley Value for n-Person Games in Generalized Characteristic Function Form

Abstract This paper is a first study of n -person games in coalitional form in which the characteristic functions are defined on all possible orders in coalitions of players. Such an approach seems to be useful in modeling some economic situations as well as some subtle relations between players in coalitions. Our main objective in this paper is to introduce axiomatically a unique value on the more general class of games indicated above. For the classical cooperative TU games our value coincides with the well-known Shapley value. We also discuss probabilistic values on the space of generalized games.
The Forensic Algorithm on Facebook Using Natural Language Processing

These days, social media has played a significant role in daily life of all people and ages in order to communicate as well as express their thoughts and feelings. In this paper, the authors have studied user data from social media (Facebook) whose shared posts are positive, and also the negative side posts that may lead to negative affect personally or can be further extended to the community and nation level. The purposes are to identify users who have commented on the negative side that may be a lawbreaker on Computer related crime. On this which beneficial about investigation for legal proceeding and it facilitate for the police or people who take a part in the operation on law. It also contributes in the community at large to peacefulness. The effective Naïve-Bayes classifier is used in order to classify these two user groups. It significantly shows that analyzing social media data by using Naïve Bayes model presented sharing positive and negative views accurately as well as reflects satisfied results.
Applying Deep Learning in Augmented Reality Tracking

An existing deep learning architecture has been adapted to solve the detection problem in camera-based tracking for augmented reality (AR). A known target, in this case a planar object, is rendered under various viewing conditions including varying orientation, scale, illumination and sensor noise. The resulting corpus is used to train a convolutional neural network to match given patches in an incoming image. The results show comparable or better performance compared to state of art methods. Timing performance of the detector needs improvement but when considered in conjunction with the robust pose estimation process promising results are shown.
The Importance of Substance-Related Sexual Victimization

Data on risk perception, sexual victimization, and substance use were obtained via surveys from 496 female college students to determine what factors influence risk perception using a written vignette in which participants make a hypothetical decision to leave a potentially risky situation. Experiences of substance-related (SR) victimization, rather than forcible victimization, were associated with significantly delayed risk perception. SR victimization victims reported feeling uncomfortable significantly later and leaving the scenario significantly later than non-victims. SR victimization victims also had significantly higher scores on heavy episodic drinking (HED), marijuana use, alcohol-related tolerance, and blackouts. Both substance use (HED and marijuana use) and alcohol-related problems (tolerance and blackouts) mediated the link between SR victimization and risk perception in the form of behavioral leave response. In contrast, only HED and tolerance mediated the link between SR victimization and risk recognition. Findings suggest the importance of differentiating types of victimization in predicting risk perception and of addressing substance use in sexual victimization risk reduction interventions.
Labeling Agreement Level and Classification Accuracy

This paper covers an experiment that investigates the relation between the quality of the dataset and the performance of the classifier. It demonstrates that dataset with less noisy labels, i.e., higher agreement level between labelers can achieve better classification accuracy results. In order to set the experiment, we divided human annotated Arabic Twitter dataset under two levels of majority voting ratio: low and high. Then, we reported the credibility prediction accuracy results under these two levels. It was found that by using labeled dataset with low level of agreement between labelers means low ratio of majority voting class, the accuracy was in the range (32% - 50.5%) whereas with labeled dataset with high percentage of majority voting class, it was between (62.8% - 66.7%). This finding clarifies that improving the quality of labeling by reducing the effect of noisy labels would yield better classification results.
Childhood Sexual Abuse and Its Association With Adult Physical and Mental Health

Childhood sexual abuse (CSA) occurs across the world, with a prevalence of 20% internationally. Our aim was to investigate the associations between CSA, CSA plus adult violence experiences, and selected self-reported physical and mental health in a community sample of women. Data from 7,700 women aged 28-33 years from the 1973-1978 cohort who completed Survey 4 of the Australian Longitudinal Study on Women’s Health (ALSWH) were analyzed. Questions about prior abuse experience such as child sexual abuse, IPV, adult physical and sexual assaults, andphysical and mental health. Women who experienced CSA were 1.4 times more likely to experience bodily pain (adjusted odds ratio [AOR] = 1.37, confidence interval [CI] = [1.19, 1.58]), 1.3 times more likely to have poorer general health (AOR = 1.33, CI = [1.15, 1.54]), and 1.4 times more likely to be depressed in the past 3 years (AOR = 1.44, CI = [1.22, 1.71]) compared with those without abuse. Women who experienced both CSA and adult violence were 2.4 to 3.1 times more likely to experience poor general (AOR = 2.35, CI = [1.76, 3.14]) and mental health (AOR = 2.69, CI = [1.98, 3.64]), and suffer from depression (AOR = 2.84, CI = [2.13, 3.78]) and anxiety (AOR = 3.10, CI = [2.12, 4.53]) compared with women with no abuse. This study demonstrates the importance of CSA in pain and poorer long-term mental and physical health. It emphasizes how prior CSA may amplify pain and poorer long-term mental and physical health among women who are again exposed to violence in adulthood.
Interactive segmentation method on stereo images

Segmentation problem dates back to a couple of decades and many solutions have been proposed so far. The fact that there is still no solution with optimum performance justifies the efforts towards new studies. This study concentrates on keeping the user interaction in the loop for superior results. Proposed technique extends previous knowledge on monoscopic image segmentation to stereoscopic footage with little extra effort. Image representative regions corresponding to background and foreground are indicated through human supervision. An MRF based energy minimization technique where user inputs are applied only on one of the stereoscopic pairs is utilized. Propagation of single view information on the stereo pair is supplied by a sparse feature matching idea. This eliminates the necessity of dense disparity matching and hence removes a computationally complex step from the pipeline. Segmentation results have been evaluated on a ground truth stereo segmentation dataset and superior results with minimum user interaction are obtained even without dense disparity estimation.
Rapid Iron Reduction Rates Are Stimulated by High-Amplitude Redox Fluctuations in a Tropical Forest Soil.

Iron oxides are important structural and biogeochemical components of soils that can be strongly altered by redox-driven processes. This study examined the influence of temporal oxygen variations on Fe speciation in soils from the Luquillo Critical Zone Observatory (Puerto Rico). We incubated soils under cycles of oxic-anoxic conditions (τoxic:τanoxic = 1:6) at three frequencies with and without phosphate addition. Fe(II) production, P availability, and Fe mineral composition were monitored using batch analytical and spectroscopic techniques. The rate of soil Fe(II) production increased from ∼3 to >45 mmol Fe(II) kg-1 d-1 over the experiment with a concomitant increase of an Fe(II) concentration plateau within each anoxic period. The apparent maximum in Fe(II) produced is similar in all treatments, but was hastened by P-amendment. Numerical modeling suggests the Fe(II) dynamics can be explained by the formation of a rapidly reducible Fe(III) phases derived from the progressive dissolution and re-oxidation of native Fe(III) oxides accompanied by minor increases in Fe reducer populations. The shift in Fe(III) reactivity is evident from Fe-reducibility assays using Shewanella sp. , however was undetectable by chemical extractions, Mössbauer or X-ray Absorption spectroscopies. More broadly, our findings suggest Fe reduction rates are strongly coupled to redox dynamics of the recent past, and that frequent shifts in redox conditions can prime a soil for rapid Fe-reduction.
Moderating Effect of Negative Peer Group Climate on the Relation Between Men’s Locus of Control and Aggression Toward Intimate Partners

The present study sought to examine the interactive effects of an external locus of control and interaction in a negative peer group climate on men’s perpetration of physical aggression and infliction of injury toward their female intimate partners. Participants were 206 heterosexual males recruited from the metro-Atlanta community who completed self-report measures of external locus of control, involvement in a negative peer group climate, and physical aggression and infliction of injury against intimate partners during the past 12 months. Negative peer group climate was conceptualized as a peer group that displays behavior which may instigate aggressive norms, attitudes, and behaviors. Results indicated that men with an external locus of control were more likely to perpetrate physical aggression toward and inflict injury on their intimate partners if they reported high, but not low, involvement in a negative peer group climate. These results extend current research suggesting external locus of control as a risk factor for intimate partner aggression by highlighting the impact of negative peer groups. Implications and future intervention research are discussed.
Energy density and diet quality among Brazilian workers

Purpose – The purpose of this paper is to evaluate the energy density (ED) of workers' diets and examine their relationship with nutrient intake, diet quality, socio‐demographic and anthropometric factors.Design/methodology/approach – Dietary data were collected by a 24‐hour recall. ED, defined as energy per unit weight of diet, included all food and excluded all beverages. Diet quality was evaluated using the Brazilian version of the health eating index. The associations between ED and socio‐demographic variables and body mass index were examined using regression models.Findings – The study evaluated 201 individuals: 51 percent male; mean age 33.4 years (SD=9.5); 43 percent overweight. Women and men presented similar mean ED: 1.99 (95 percent CI: 1.90‐2.09) and 1.95 (95 percent CI: 1.89‐201). ED was inversely associated with age (β: −0.009; 95 percent CI: −0.015; −0.002) and with leisure physical activity (β: −0.049; 95 percent CI: −0.096; −0.002) and directly associated with liquid intake during meals (.