Miracle-dz/UniFAR-FTUs huggingface dataset:
Mechanism of Naphthaleneacetic Acid Conjugation NO

Formation of naphthaleneacetic acid-glucose (NAGlu) in de- tached leaves, floating on a-naphthaleneacetic acid-1-V4C (NAA, 0.05 microcurie per milliliter, 3.1 ,uM)-buffer solution (phos-phate-citrate, pH 4.2) began immediately while there was a 2-to 4-hour lag before NAA-asparatate (NAAsp) could be detected. Subsequent increase in the NAAsp conjugate reflected a decrease in free NAA to 1 to 2 % of the total radioactivity taken up. Pretreatment with 31 gM 'C-NAA for 18 hours doubled NAAsp formation after transfer for 4 hours to '4C-NAA. Pretreatment with ethylene, as ethephon (up to 400 milligrams per liter) or ethylene gas (10 microliters per liter), did not induce NAAsp formation. In the presence of NAA, ethylene had no effect on NAA conjugation. Similarly, CO2 (5%) did not modify the formation of the conjugates. Rhizobitoxine (1.87 uM) inhibited NAA-induced ethylene production but did not prevent NAA-induced formation of NAAsp. We concluded that the conjugation of NAA with aspartic acid is not mediated by ethylene.
STOCHASTIC AND DETERMINISTIC SIS PATCH MODEL

Here, we consider an SIS epidemic model where the individuals are distributed on several distinct patches. We construct a stochastic model and then prove that it converges to a deterministic model as the total population size tends to inﬁnity. We next study the equilibria of the deterministic model. Our main contribution is a stability result of the endemic equilibrium in the case R 0 > 1. Finally we compare the equilibria with those of the homogeneous model, and with those of isolated patches.
Comparison of different types of therapy for overactive bladder: A systematic review and network meta-analysis

To compare the efficacy and safety of different interventions [including antimuscarinics, mirabegron, OnabotulinumtoxinA, sacral neuromodulation (SNM) and peripheral tibial nerve stimulation (PTNS)] for treating idiopathic overactive bladder (OAB). PubMed, Embase, Cochrane Library, and other sources were searched for randomized controlled trials (RCTs) comparing interventions for overactive bladder from 1 January 2000 to 19 April 2021. A systematic review and network meta-analysis were performed by two authors independently. Fifty-five RCTs involving 32,507 patients were included in this analysis. Overall, antimuscarinics, mirabegron, OnabotulinumtoxinA, sacral neuromodulation, and peripheral tibial nerve stimulation were more efficacious than placebo, and sacral neuromodulation showed the best effect for reducing micturition frequency, urgency episodes and urgency urinary incontinence episodes. OnabotulinumtoxinA was the best intervention for achieving reductions of 100 and ≥50% in the number of urinary incontinence episodes/day, and peripheral tibial nerve stimulation was the best intervention for reducing urinary incontinence episodes. Antimuscarinics, mirabegron and peripheral tibial nerve stimulation had a similar efficacy for reducing micturition frequency, urinary incontinence episodes and urgency urinary incontinence episodes. The results revealed that all interventions examined herein were efficacious for managing adult overactive bladder syndrome compared with placebo. Furthermore, sacral neuromodulation and OnabotulinumtoxinA were the most efficient treatments for overactive bladder. Systematic review registration [https://www.crd. york.ac. uk/prospero/display_record. php? RecordID=251966], identifier [CRD42021251966].
A Comparison Between the Online Prediction Models CancerMath and PREDICT as Prognostic Tools in Thai Breast Cancer Patients

Background and Purpose: Web-based prognostic calculators have been developed to inform about the use of adjuvant systemic treatments in breast cancer. CancerMath and PREDICT are two examples of web-based prognostic tools that predict patient survival up to 15 years after an initial diagnosis of breast cancer. The aim of this study is to validate the use of CancerMath and PREDICT as prognostic tools in Thai breast cancer patients. Patients and Methods: A total of 615 patients who underwent surgical treatment for stage I to III breast cancer from 2003 to 2011 at the Division of Head Neck and Breast Surgery, Department of Surgery, Siriraj Hospital, Mahidol University, Thailand were recruited. A model-predicted overall survival rate (OS) and the actual OS of the patients were compared. The ef ﬁ cacy of the model was evaluated using receiver-operating characteristic (ROC) analysis. Results: For CancerMath, the predicted 5-year OS was 88.9% and the predicted 10-year OS was 78.3% (p<0.001). For PREDICT, the predicted 5-year OS was 83.1% and the predicted 10-year OS was 72.0% (p<0.001). The actual observed 5-year OS was 90.8% and the observed 10-year OS was 82.6% (p<0.001). CancerMath demonstrated better predictive performance than PREDICT in all subgroups for both 5- and 10-year OS. In addition, there was a marked difference between CancerMath and observed survival rates in patients who were older as well as patients who were stage N3. The area under the ROC curve for 5-year OS in CancerMath and 10-year OS was 0.74 (95% CI; 0.65 – 0.82) and 0.75 (95% CI; 0.68 – 0.82). In the PREDICT group, the area under the ROC curve for 5-year OS was 0.78 (95% CI; 0.71 – 0.85) and for 10-year OS, it was 0.78 (95% CI; 0.71 – 0.84). Conclusion: CancerMath and PREDICT models both underestimated the OS in Thai breast cancer patients. Thus, a novel prognostic model for Thai breast cancer patients is required.
Gabor Feature based Abnormal Event Detection

- In today’s world security in public places, such as airport, railway stations, shopping malls etc is highly essential, that’s why abnormal event detection in video has attracted more attention in the computer vision research community. This paper presents a novel approach for detection of abnormal events and upon detection of such events notification is sent to concerned authority. The proposed algorithm specifies Gabor filter based features used for motion analysis. Extracted features are given to Artificial Neural Network which is used to recognize whether the input event is normal or abnormal. Proposed algorithm is very much efficient and provides high level of accuracy.
Design and implementation of a privacy preserving electronic health record linkage tool in Chicago

, , ABSTRACT . Objective To design and implement a tool that creates a secure, privacy preserving linkage of electronic health record (EHR) data across multiple sites in a large metropolitan area in the United States (Chicago, IL), for use in clinical research. Methods The authors developed and distributed a software application that performs standardized data cleaning, preprocessing, and hashing of patient identifiers to remove all protected health information. The application creates seeded hash code combinations of patient identifiers using a Health Insurance Portability and Accountability Act compliant SHA-512 algorithm that minimizes re-identification risk. The authors subsequently linked individual records using a central honest broker with an algorithm that assigns weights to hash combinations in order to generate high specificity matches. Results The software application successfully linked and de-duplicated 7 million records across 6 institutions, resulting in a cohort of 5 million unique records. Using a manually reconciled set of 11 292 patients as a gold standard, the software achieved a sensitivity of 96% and a specificity of 100%, with a majority of the missed matches accounted for by patients with both a missing social security number and last name change. Using 3 disease examples, it is demonstrated that the software can reduce duplication of patient records across sites by as much as 28%. Conclusions Software that standardizes the assignment of a unique seeded hash identifier merged through an agreed upon third-party honest broker can enable large-scale secure linkage of EHR data for epidemiologic and public health research. The software algorithm can improve future epidemiologic research by providing more comprehensive data given that patients may make use of multiple healthcare systems.
“I Have Such a Great Care” – Geriatric Patients’ Experiences with a New Healthcare Model: A Qualitative Study

Purpose: Coordinated care is important for the health and well-being of geriatric patients. However, continuity of care is lacking in many countries. Several studies have shown that case management can help to meet these requirements in health care and investigated positive effects. The project RubiN (Regional ununterbrochen betreut im Netz; Continuous care in a regional network) was developed to provide regional care- and case management for outpatient care of the elderly (age >70 years) in a primary care setting. The aim of this qualitative approach was to explore experiences and attitudes of geriatric patients towards the newly developed complex care- and case-management intervention RubiN. Patients and Methods: Qualitative interviews with a purposive sample of geriatric patients enlisted in the RubiN intervention networks were conducted. The collected data was transcribed and evaluated using qualitative content analysis. A deductive-inductive approach was used in generating thematic categories. Results: Forty-four telephone interviews were performed. Two key categories were identified to describe patients’ experiences regarding care delivered by a care- and case manager (CCM), namely “role of CCM” and “changes through RubiN”. Results demonstrated that care performed by CCMs is perceived positively by geriatric patients. A main finding of this study was that geriatric patients experienced a sense of security through the care provided by CCMs. CCMs were perceived as highly competent people, having all the necessary skills to provide continuity of care. Conclusion: This study illustrates the importance of trust between care provider and care recipient. It also shows that geriatric patients appreciate the continuous, professional care and structural and functional support provided by qualified CCMs.
Impact of oxidation morphology on reduced graphene oxides upon thermal annealing

Thermal reduction of graphene oxide ( GO ) is an essential technique to produce low-cost and higher quality graphene-based materials and composites used today in a plethora of applications. However, despite a demonstrated ef ﬁ ciency of high-temperature annealing in reducing the oxygen content of GO, the impact of the morphology of the initially oxidized samples on the restored sp 2 graphene plane versus remaining sp 3 imperfections remains unclear and out-of-control. Here using classical molecular dynamics, we simulate the process of thermal reduction on several GO samples for a variety of initial conditions and elucidate how both the concentration of oxygen functional groups and their spatial distribution jeopardize the reduction process ef ﬁ ciency. Our simulations suggest thermal annealing strategies to further optimize the crystallinity of reduced GO, enhancing their transport properties and hence making the resulting composites even more performant for electronic applications.
New insights into the regulation of the pac gene from Escherichia coli W ATCC 11105

The regulation of the pac gene encoding the penicillin G acylase of Escherichia coli W ATCC 11015 has been investigated by a molecular approach using lacZ as a reporter gene. This analysis revealed that a region of 170 bp located upstream of the pac structural gene contains the regulatory sequences that control its expression. The cAMP receptor protein is involved not only in the catabolite repression of penicillin G acylase production caused by glucose but also in the induction of pac gene expression by phenylacetic acid. Primer extension analyses have demonstrated that the transcription of the pac gene can be initiated from at least three different promoters. Although all these promoters are functional, their relative activity depends on the transcribed gene, the P1 and P3 promoters being more active in the presence of the pac gene, whereas the P2 promoter was stronger when the upstream region of the pac gene was fused to the lacZ reporter. A deletion of the region surrounding the 3 10 box of the P3 promoter produced a constitutive expression of the fused gene indicating that this sequence is required for phenylacetic acid induction and suggesting that the expression of the pac gene is regulated by a repression mechanism. This work reveals that the regulation of the pac gene is more complex than previously envisioned and provides new clues to investigate further this interesting regulatory system. (cid:223) 1999 Federation of European Microbiological Societies. Published by Elsevier Science B.V. rights
(2017) Rapid flood inundation mapping using social media, remote sensing and topographic data. Natural Hazards . ISSN 1573-0840

Flood events cause substantial damage to urban and rural areas. Monitoring water extent during large-scale ﬂooding is crucial in order to identify the area affected and to evaluate damage. During such events, spatial assessments of ﬂoodwater may be derived from satellite or airborne sensing platforms. Meanwhile, an increasing availability of smartphones isleading to documentationofﬂoodeventsdirectly byindividuals,withinformationshared in real-time using social media. Topographic data, which can be used to determine where ﬂoodwater can accumulate, are now often available from national mapping or governmental repositories. In this work, we present and evaluate a method for rapidly estimating ﬂood inundation extent based on a model that fuses remote sensing, social media and topographic data sources. Using geotagged photographs sourced from social media, optical remote sensing and high-resolution terrain mapping, we develop a Bayesian statistical model to estimate the probability of ﬂood inundation through weights-of-evidence analysis. Our experiments were conducted using data collected during the 2014 UK ﬂood event and focus on the Oxford city and surrounding areas. Using the proposed technique, predictions of inundation were evaluated against ground-truth ﬂood extent. The results report on the quantitative accuracy of the multisource mapping process, which obtained area under receiver operating curve values of 0.95 and 0.93 for model ﬁtting and testing, respectively.
Site-directed mutagenesis and CBM engineering of Cel5A (Thermotogamaritima)

In order to make cost-effective bioethanol from dynamic lignocellulosic material, we require potentially acting and stable cellulolytic enzymes. In our investigation, the hyperthermostable endoglucanase Cel5A from Thermotoga maritima was subjected to site-directed mutagenesis and carbohydrate-binding module (CBM) engineering. For this purpose, amino acids around the active-site region were targeted. Results indicated that ﬁve single mutants showed a shift in optimal pH from 5 to 5.4. The N147E mutant displayed 10% higher activity than native Cel5A. Domain engineering was performed with fungal and bacterial CBM. In addition, CBM1 from (CBHII) Trichoderma reesei and CBM6 from Clostridium stercorarium xylanase A were fused with Cel5A. Both the CBM-engineered Cel5A showed 14–18-fold higher hydrolytic activity towards Avicel. Immuno-gold labeling assay of engineered enzymes further indicated the relativity that exists between binding ability
Wideband Multi-Mode Leaky-Wave Feed for Scanning Lens Phased Array at Submillimeter Wavelengths

— In this paper, we propose a hybrid electromechanical scanning lens antenna array architecture suitable for the steering of highly directive beams at submillimeter wavelengths with field-of-views (FoV) of ±25°. The concept relies on combining electronic phase shifting of a sparse array with a mechanical translation of a lens array. The use of a sparse phased array significantly simplifies the RF front-end (number of active components, routing, thermal problems), while the translation of a lens array steers the element patterns to angles off-broadside, reducing the impact of grating lobes over a wide FoV. The mechanical translation required for the lens array is also significantly reduced compared to a single large lens, leading to faster and low-power mechanical implementation. In order to achieve wide bandwidth and large steering angles, a novel leaky wave lens feed concept is also implemented. A 550 GHz prototype was fabricated and measured demonstrating the scanning capabilities of the embedded element pattern and the radiation performance of the leaky wave fed antenna.
Sensitivity to Change of the Roland-Morris Back Pain Questionnaire: Part 1

Background and Purpose. This study estimated the Roland-Morris Back Pain Questionnaire's (RMQ) change score that best classified patients as those who had achieved an important change and those who had not achieved an important change. The study also investigated whether the estimate of change was dependent on patients' initial scores. Subjects and Methods. The RMQwas administered to 226 patients with low back pain of less than 6 weeks' duration during their initial visit for physical therapy and following 3 to 6 weeks of treatment. A global rating of change was used to classify patients as those who had changed an important amount and those who had not changed. Receiver operating characteristic curves were used to identify the RMQ change score that most accurately classified patients with respect to important change. This analysis was repeated for 5 overlapping subsamples of patients with initial scores 0 to 8, 5 to 12, 9 to 16, 13 to 20, and 1'7 to 24. Results. The area under the receiver operating characteristic curves increased when patients' initial scores were taken into account. Estimates of important change were 2, 4, 5, 8, and 8 for the initial score intervals mentioned above. Conclusion and Discussion. Important change appears to be dependent on patients' initial RMQ scores. Subsequent inquiry using different hypotheses would add support to the estimates of important change found in this study. [Stratford PW, Binkley JM, Riddle DL, Guyatt GH. Sensitivity to change of the Roland-Morris Back Pain Questionnaire: part 1. Phys Tho. 1998;'78: 1186-1196.1
Computational Biology/Bioinformatics on a budget.

: Computational biology/bioinformatics is very expensive, but thanks to the recent developments in the semiconductor industry there is a relative budget solution. Here I present how a budget lab was set up based on the grant experience for in silico screening of compounds, which target the quorum sensing system of P. aeruginosa . This knowledge could be used by other lower income countries that are trying to perform computational biology/bioinformatics studies.
A hybrid Euler–Hadamard product and moments of (cid:16) 0 .(cid:26)/

Keating and Snaith modeled the Riemann zeta-function (cid:16). s/ by characteristic polynomials of random N (cid:2) N unitary matrices, and used this to conjecture the asymptotic main term for the 2k -th moment of (cid:16). 1=2 C it/ when k > (cid:0) 1=2 . However, an arithmetical factor, widely believed to be part of the leading term coefﬁcient, had to be in-serted in an ad hoc manner. Gonek, Hughes and Keating later developed a hybrid formula for (cid:16). s/ that combines a truncation of its Euler product with a product over its zeros. Using it, they recovered the moment conjecture of Keating and Snaith in a way that naturally includes the arithmetical factor. Here we use the hybrid formula to recover a conjecture of Hughes, Keating and O’Connell concerning the discrete moments of the derivative of the Riemann zeta-function averaged over the zeros of (cid:16). s/ , incorporating the arithmetical factor in a natural way.
Analytical Calculation of the Mergers of Black Hole–Neutron Star Binaries

Black hole (BH)–neutron star (NS) mergers have been studied as one of the primary sources of gravitational wave radiation and a strong candidate for the sources of short-hard gamma-ray bursts (SHBs). In this work, we investigated the criterion for a tidal disruption to occur outside the innermost stable circular orbit with various initial conditions of BH and NS. We studied the merger processes due to Roche-lobe overﬂow by an analytical method with Newtonian orbital functions. By using the polytropic equation of state for the NS, we calculated the time scale of merger for both irrotating (IR) and corotationg (CR) conﬁgurations. The resulting time scale is (cid:3) 10 (cid:4) 3 s for the IR case, which agrees well with that of hydrodynamic simulations. We present a simple comparison with the most recent simulation result. The connection to the SHBs is also discussed.
VHRM_A_297720 95..102

1Division of Cardiology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA; 2Department of Biostatistics, University of Washington, Seattle, WA, USA; 3Division of Public Health Sciences, Wake Forest School of Medicine, WinstonSalem, NC, USA; 4Cardiology Division, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; 5Departments of Cardiology, Epidemiology and Prevention, Wake Forest University, Winston-Salem, NC, USA; 6Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA; 7Cardiology Section, San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA; 8Departments of Medicine, and Epidemiology and Biostatistics, University of California, San Francisco, CA, USA; 9Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA, USA; 10Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA Background: Endothelial dysfunction is associated with common risk factors for AF and has been implicated in the pathophysiology of atrial fibrillation (AF) through a variety of mechanisms. We determined the prospective association of brachial flow-mediated dilation (FMD) with incident AF among older adults. Methods: We included 2027 Cardiovascular Health Study participants (mean age=78.3 years, male=39%, Black=17%) who underwent brachial FMD measurement at the 1997 to 1998 clinic visit. Incident AF was ascertained by study electrocardiograms, hospital discharge diagnosis coding and Medicare claims data. Cox regression models were used to examine the association between FMD and incident AF. Results: We identified 754 incident of AF cases (37%) over a median follow-up of 11.0 years. After adjusting for age, sex, race, height, weight, cardiovascular disease, cigarette smoking, hypertension, diabetes, kidney function, c-reactive protein, physical activity, alcohol consumption, and statins, the risk of AF did not differ according to brachial FMD response (4th vs 1st quartile hazard ratio (HR)=1.01, 95% confidence interval (CI): 0.81, 1.26; per FMD unit increment HR=1.01, 95% CI: 0.97, 1.05). Conclusion: We found no relationship between brachial FMD and the risk of developing AF in this elderly cohort. Our findings suggest that the utility of brachial FMD as a risk marker for AF in older individuals is minimal.
The In uencing Factors of Self-evaluation in Adolescents: A Structural Equation Modeling

Xiaobing Zhai Wuhan University of Science and Technology Lihua Di Wuhan University of Science and Technology Ehab S Eshak Osaka University Graduate School of Medicine Can Jiang The University of Sydney Faculty of Science Jing Zeng Wuhan University of Science and Technology Zhongnan Branch: Wuchang University of Technology Mei Yang Wuhan University of Science and Technology School of Medicine Jia Zhou Wuhan University of Science and Technology School of Medicine Yushuang Peng Wuhan University of Science and Technology School of Medicine Yanan Zhang Wuhan University of Science and Technology School of Medicine Jinhong Cao wuhan university school of Health Sciences Bing Xiang (  764356760@qq.com ) School of Medicine, Wuhan University of Science and Technology, No.2 Huangjiahu West Road, Wuhan, Hubei 430065, China https://orcid.org/00000003-0925-7104