Miracle-dz/UniFAR-FTUs huggingface dataset:
Cancer-related distress and unmet needs among newly diagnosed and longer-term cancer survivors from a community-based distress screening program.

220 Background: As survival rates increase among cancer patients, quality of life needs become more salient. Cancer Support Source (CSS) is a distress screening, referral and follow up program that uses a validated distress screening tool and referral algorithm to link cancer patients to resources tailored to their needs. The objective of this study was to describe psychosocial concerns and unmet needs at different times since cancer diagnosis. METHODS English speaking cancer survivors (n = 905) across 26 affiliates of a nationwide cancer support organization participated in the CSS program by first completing a screening tool, including a 4 item depression subscale. Participants rated the level of concern (0 to 4) about 15 items and identified the help they wanted for each item (talk with a member of your health care team and/or connect you with online resources). We used regression analysis, adjusting for age, to examine differences by time since diagnosis ( < 1 y; ≥ 1 y) in level of distress; type of concerns (rated ≥ 2); and items selected to talk with the health care team. RESULTS The sample was 78% female, 10% Latino, 9% Black, and median age 57 y. 41% were breast cancer survivors, 6% lung, and 6% colorectal. More than half were within 1 y of their diagnosis (61%, n = 507); 39% ≥ 1 y (n = 331). Those newly diagnosed ( < 1 y) had significantly higher levels of distress (p = 0.011); increased risk for depression (p = 0.007); and more likely to be concerned about changes in work, school, or home life; body image; feeling nervous or afraid; worry about the future; and making a treatment decision (p < 0.05). Among those who indicated that an item was a concern, newly diagnosed patients were significantly more likely to want to talk to their health care team about pain; financial worries; exercising; feeling lonely or isolated; feeling nervous or afraid; and worry about the future (p < 0.05). CONCLUSIONS These findings suggest that patients are more distressed and more likely to want to talk about their psychosocial needs within the first year of a cancer diagnosis. Future research should evaluate efforts to provide tailored resources within the first year of a diagnosis when distress levels are highest.
One-to-cloud one-time pad data encryption: Introducing virtual prototyping with PSpice

In this paper, we examine the design and application of a one-time pad encryption system for protecting data stored in the Cloud. Personalising security using a one-time pad generator at the client-end protects data from break-ins, side-channel attacks and backdoors in public encryption algorithms. The one-time pad binary sequences from modified analogue chaos oscillators initiated by noise encoded client data locally. Specific “one-to-Cloud” storage applications give control to the end user but without the key distribution problems associated with one-time pad encryption. Development of the prototype was aided by “Virtual Prototyping” in the latest version of Cadence OrCAD PSpice®. This addition allows the prototype simulation schematic to be connected to an actual microcontroller in real time using device model interface for bi-directional communication. using device model interface.
A fast scene change detection on MPEG coding parameter domain

This paper proposes a very fast and accurate scene change detection algorithm on MPEG coding parameter domain. The fast operation can be obtained by spatio-temporally subsampling coding information and by exploiting only coding parameters extracted in variable length decoding (VLD) stage, while the accurate detection is accomplished by examining the statistical characteristics of various scene changes on the coding parameter domain. The computer simulation shows that the proposed algorithm can accomplish detection more than 5 times faster than that of real-time playback for MPEG-2 video sequences using a standard workstation. It is also shown that most of abrupt scene changes, dissolve transitions, and wipe transitions have been successfully detected.
5-Azacytidine, a DNA methyltransferase inhibitor, induces ATR-mediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells

In this study, we investigated the cytotoxicity of 5-azacytidine, a DNA methyltransferase inhibitor, against multiple myeloma (MM) cells, and characterized DNA damage–related mechanisms of cell death. 5-Azacytidine showed significant cytotoxicity against both conventional therapy-sensitive and therapy-resistant MM cell lines, as well as multidrug-resistant patient-derived MM cells, with IC50 of ∼0.8–3 μmol/L. Conversely, 5-azacytidine was not cytotoxic to peripheral blood mononuclear cells or patient-derived bone marrow stromal cells (BMSC) at these doses. Importantly, 5-azacytidine overcame the survival and growth advantages conferred by exogenous interleukin-6 (IL-6), insulin-like growth factor-I (IGF-I), or by adherence of MM cells to BMSCs. 5-Azacytidine treatment induced DNA double-strand break (DSB) responses, as evidenced by H2AX, Chk2, and p53 phosphorylations, and apoptosis of MM cells. 5-Azacytidine–induced apoptosis was both caspase dependent and independent, with caspase 8 and caspase 9 cleavage; Mcl-1 cleavage; Bax, Puma, and Noxa up-regulation; as well as release of AIF and EndoG from the mitochondria. Finally, we show that 5-azacytidine–induced DNA DSB responses were mediated predominantly by ATR, and that doxorubicin, as well as bortezomib, synergistically enhanced 5-azacytidine–induced MM cell death. Taken together, these data provide the preclinical rationale for the clinical evaluation of 5-azacytidine, alone and in combination with doxorubicin and bortezomib, to improve patient outcome in MM. [Mol Cancer Ther 2007;6(6):1718–27]
Detecting Consumer Devices by Applying Pattern Recognition to Smart Meter Signals

Future energy supply requires an intelligent load management for efficient distribution of the available energy, at national level, as well as on a regional scale. For this purpose, one necessary prerequisite is the immediate detection of the currently connected appliances (loads), for example white or brown goods. If the devices that are currently active at the time of a data point are known, it is possible to level the load curve by means of selectively connecting and disconnecting appliances, which results in an optimized usage of the available energy. To realize the measurement of the energy consumption, we devised a low-investment system for centralized data acquisition and recorded and digitized characteristic load profiles. Afterwards, the application of different pattern matching algorithms allowed for recognizing and assigning individual loads from the measured sum signal. In the course of laboratory experiments, we could identify individual appliances and their combinations with this system.
Self-Esteem Instability and Humor Styles: Does the Stability of Self-Esteem Influence How People Use Humor?

ABSTRACT The purpose of the present study was to examine whether self-esteem instability moderated the association between self-esteem level and the use of humor. This was accomplished by examining the associations that humor styles had with self-esteem level and self-esteem instability among 499 undergraduates. The results of the present study show that self-esteem instability moderated the association between self-esteem level and humor styles such that individuals with stable high self-esteem reported the highest levels of affiliative humor as well as the lowest levels of aggressive and self-defeating humor. These results suggest that individuals with stable and unstable forms of self-esteem employ different styles of humor.
Inhibitory action of transforming growth factor beta on endothelial cells.

In the present study, we show that transforming growth factor beta (TGF-beta) strongly inhibits fibroblast growth factor-induced proliferation and motility of bovine endothelial cells in tissue culture. TGF-beta also prevents the phorbol ester-induced invasion of capillary endothelial cells into collagen matrices--i.e., blocks angiogenesis in vitro. TGF-beta promotes the incorporation of fibronectin into the extracellular matrix of endothelial cells and stimulates the secretion of other proteins--mainly of 55- and 180-kDa components. We show furthermore that endothelial cells express TGF-beta receptors similar in size to those of other tissue culture cell lines: a 280-kDa complex is present in subconfluent cells, and 85- and 72-kDa protein bands are seen in confluent cells. The various effects of TGF-beta on endothelial cells suggest that these cells are an important target of TGF-beta during wound healing and angiogenesis.
On-line battery identification for electric driving range prediction

Hybrid and electric vehicles require accurate knowledge of the battery to make an educated guess about the expected electric driving range. Range prediction is complicated by the fact that batteries are subject to external influences and aging. Also the future driving behavior is often unknown. This paper presents a model-based identification method for online parameter estimation of Li-ion batteries. This allows range prediction to anticipate on all kinds of duty cycles as well as changing battery characteristics enforced by cell degradation. In the proposed methodology, parameters values of the battery model are frequently updated with the latest measurement data. Additional state observers are utilized to keep the dynamical states of the battery model up-to-date. Altogether, this offers robustness and accuracy under varying operating conditions and for the complete battery lifetime. Experimental results are presented to validate the proposed identification method.
The Improved Algorithm of Edge Detection Based on Mathematics Morphology

In morphology, the structural elements of different sizes and shapes have different abilities in maintaining image detail and anti-noise, an adaptive algorithm of edge detection based on multi-structure and multi-scale element is presented in this paper. First, the existing morphological operators for edge detection are improved. Then, the weight coefficients of different scales and different shapes are determined respectively by using the method of morphological difference and calculating the information entropy of the edge-detected. Last, fuse together the edges to achieve the image edge. For the image with noise, the algorithm can filter out noise effectively, and the edge is continuous, smooth, clear outline. The experiment results show that the algorithm has good effect in edge detection, strong anti-noise capacity, and the objective evaluation and visual effect are good, too.
SIMILAR SPECTRA FOR THE INACTIVATION BY MONOCHROMATIC LIGHT OF TWO DISTINCT LEUCINE TRANSPORT SYSTEMS IN ESCHERICHIA COLI

Abstract—Kinetics of inactivation of two separate leucine transport systems (leucine specific and LIV) in E. coli by seven wavelengths of monochromatic light have been studied. Loss of leucine uptake is not due to generalized membrane damage causing non‐specific leucine leakage. Inactivations are usually exponential but some wavelengths show shoulders at low doses. Two‐component spectra between 254 and 435 nm occur for both transport systems. Inactivation is most efficient at 290 nm and a second peak occurs at 365 nm. Both leucine transport systems are inactivated similarly.
Identification of two types binding modes using reverse or diagonal electrophoretic zymography

Binding mode was demonstrated by Brown and Lantz. They demonstrated that enzymes bind to a fixed substrate in SDS-polyacrylamide gels and they do not migrate into the separating gel and hydrolyze the substrate. We found two types of binding modes. One was formed because of binding between the enzyme and substrate, and the other was due to a high pI value (8.8) of the enzyme. These two types were identified using reverse zymography and diagonal electrophoretic zymography. We identified two different samples showing the binding mode; the fruiting body of the oyster mushroom and culture supernatant from Bacillus sp. strain.
Influence of Per3 genotypes on circadian rhythmicity in flight cadets after militarized management.

OBJECTIVE The purpose of this study was to explore the effect of PERIOD3 (PER3) genotypes on circadian rhythmicity in flight cadets after militarized management. METHODS We performed a preliminary study in 146 newly enrolled male flight cadets. Venous blood samples were collected, and genotyping of PER3 (4/5) was determined by using PCR. The morningness-eveningness questionnaire (MEQ) survey was given to flight cadets upon enrollment and after militarized management for 24 months respectively. Comparison of frequency distribution of PER3 genotypes between cases and controls (120 well-matched civilians) was performed using the X(2) test. We also compared the circadian rhythmicity upon enrollment and 24 months after enrollment in flight cadets, and analyzed the connection of changes in circadian clock with PER3 genotypes. RESULTS The frequency distribution of PER3 genotypes in flight cadets was not significantly different from that in controls subjects. MEQ survey results showed chronotype within flight cadet group varied widely at the two time-points: the moderately morning type (50%) and the neither type (41.1%) upon enrollment; the neither type (76.7%) and the moderately morning type (21.2%) 24 months after enrollment. The circadian rhythm of individuals with the PER3 (5/5) genotype showed no significant difference before and after 24 months of militarized management, whereas notable changes were found in individuals with the PER3 (4/4) genotype (n=116, X(2) =37.26, P < 0.001). CONCLUSION In conclusion, we provide some evidence that circadian rhythm of flight cadets with the PER3 (5) allele are less likely to be affected compared to those with the PER3 (4) allele.
Limitrin, a novel immunoglobulin superfamily protein localized to glia limitans formed by astrocyte endfeet

We report the molecular cloning of a new member of the transmembrane‐type immunoglobulin superfamily and designate the encoded protein as limitrin, since it localized selectively to glia limitans in mouse brain. Limitrin cDNA was obtained using a subtractive hybridization procedure designed to identify molecules responsible for blood‐brain barrier function. Western blots using a limitrin‐specific antibody demonstrated that the gene product is expressed significantly in mouse brain and primary murine astrocytes and is distributed in the plasma membrane. Immunohistochemical studies using confocal and electron microscopy clearly demonstrated highly polarized localization in astroglial endfeet in the perivascular region and under the pia mater in vivo. Limitrin is expressed in the spinal cord and in many areas of the brain, but not in the median eminence or subfornical organ (the circumventricular organs), where the blood‐brain barrier is lacking. Disruption of the blood‐brain barrier by cold injury resulted in a drastic reduction in limitrin expression. Furthermore, during retrieval from cold injury, the increased expression of limitrin in perivascular endfeet correlated with the recovery of angiogenesis in capillaries within the lesion margins. Our results suggest that limitrin is physically and functionally associated with the blood‐brain barrier, implying that this protein may be useful as a diagnostic tool of barrier integrity. © 2003 Wiley‐Liss, Inc.
A modified radioimmunoassay for antibodies against Brucella abortus

Summary The radioimmunoassay for brucellosis previously reported from this laboratory was a sensitive and useful method for detecting antibody against Brucella abortus in bovine serum. Changes in the procedure have improved sensitivity, have apparently increased interassay precision, and have made the assay easier to perform.
Strain distribution in the proximal human femoral metaphysis

Abstract There is significant interest in the stress—strain state in the proximal femoral metaphysis, because of its relevance for hip fractures and prosthetic replacements. The scope of this work was to provide a better understanding of the strain distribution, and of its correlation with the different directions of loading, and with bone quality. A total of 12 pairs of human femurs were instrumented with strain gauges. Six loading configurations were designed to cover the range of directions spanned by the hip joint force. Inter-specimen variability was reduced if paired specimens were considered. The principal strain magnitude varied greatly between loading configurations. This suggests that different loading configurations need to be simulated in vitro. The strain magnitude varied between locations but, on average, was compatible with the strain values measured in vivo. The strain magnitudes and the direction of principal tensile strain in the head and neck were compatible with the spontaneous fractures of the proximal femur reported in some subjects. The principal tensile strain was significantly larger where the cortical bone was thinner; the compressive strain was larger where the cortical bone was thicker. The direction of the principal strain varied significantly between measurement locations but varied little between loading configurations. This suggests that the anatomy and the distribution of anisotropic material properties enable the proximal femur to respond adequately to the changing direction of daily loading.
A FREE BOUNDARY PROBLEM RELATED TO SINGLE-LAYER POTENTIALS

Let › be a bounded domain in R n with su-ciently regular boundary i , and let J be the operator which maps a function f on i to the restriction Jf to i of its single layer potential. In the present paper, we consider the problem of characterizing those domains › for which the constant function f · 1 is an eigenfunction for J and some related inverse problems. One of our main results concerning the former problem in R 2 » C is the following: If i is a rectiflable curve such that Cn › is a Smirnov domain and f· 1 is an eigenfunction for J , then i is a circle.
The oxidative state of children with cyanotic and acyanotic congenital heart disease.

OBJECTIVE The type of congenital heart disease, early diagnosis, and treatment modality all play an important role in the morbidity and mortality of these diseases. This study examined the relationship between congenital heart disease and oxidative stress in children with cyanotic and acyanotic congenital heart disease. METHODS In this case-controlled cross-sectional study, the study groups consisted of 29 patients with cyanotic heart disease, 30 patients with acyanotic heart disease, and a control group of 32 healthy individuals. For all groups, the total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) were calculated. Of the cyanotic group, 12 were diagnosed with tetralogy of Fallot, 7 with transposition of the great arteries, 4 with tricuspid atresia, 4 with double outlet right ventricle and 2 with truncus arteriosus. In the acyanotic group 19 patients had ventricular septal defect (VSD), 5 atrial septal defect (ASD) and 6 patent ductus arteriosus (PDA). Statistical analyses were performed using Chi-square, Mann-Whitney U and Kruskal-Wallis tests. RESULTS The plasma TAS, TOS, and OSI were significantly higher in the cyanotic group than in the acyanotic group (p<0.0001, p<0.01, and p<0.01, respectively) and controls (p<0.0001, p<0.0001, and p<0.0001, respectively). A comparison between the acyanotic and control groups showed no statistical differences. CONCLUSION The level of oxidative stress in patients with cyanotic congenital heart disease was significantly higher than in the acyanotic and control groups, which were similar.
REVERSAL OF THE GLUCOSE INHIBITION OF HISTIDASE BIOSYNTHESIS IN AEROBACTER AEROGENES

Glucose inhibits the biosynthesis of several inducible enzymes in Aerobacter aerogenes. Previous studies (Neidhardt and MIagasanik, 1956a) have indicated that this inhibitory effect is not due to (a) failure of the inducing agents to penetrate the cell, (b) the high growth rate of the cells in a glucose-containing medium, or (c) a deficit of the substances known to be essential for protein formation. Attempts to reverse this inhibition of enzyme biosynthesis by enrichment of the minimal medium with amino acid, purine-pyrimidine, or vitamin supplements have been unsuccessful (Neidhardt and M\Iagasanik, 1956a). The studies reported in this paper describe a different approach to this problem: rather than enriching the glucose medium with organic supplements, the organism was placed in a situation in which the formation of an inducible enzyme in the presence of glucose was a prerequisite for growth.
New challenges in power conditioning for telecommunications

Since standalone power systems with renewable energy generators are becoming competitive with respect to a grid connection solution for supplying telecommunications equipments in remote areas, power electronics converters are facing new challenges to simultaneously match the parameters of the renewable energies and to fulfil the telecommunications strict requirements. This paper presents a variety of DC-DC converter topologies. The most capable ones are studied and compared through simulation results. FB ZVS converter is the most efficient and LCL-type SRC with capacitive output is the most robust (allowing to keep a ZVS operation for a larger range of input voltage and load demand).
Mediating Role of Self Efficacy on the Relationship between Subjective Vitality and School Burnout in Turkish Adolescents

The purpose of this paper was to examine whether self efficacy might play a mediating role between subjective vitality and school burnout in Turkish adolescents. The participants were 344 high school students who completed a questionnaire package that included the School Burnout Scale, the Subjective Vitality Scale, and the General Self-Efficacy Scale. Relationships between self efficacy, vitality and school burnout were tested using Pearson Product Moment Correlation Coefficient and predictions of each variable by the domains of the other were calculated with Linear Regression Analysis (LRA). Findings showed that subjective vitality, school burnout and self-efficacy were related to each others. Hierarchical Regression Analysis results indicated that self-efficacy partially mediated the relationship between subjective vitality and school burnout.