Miracle-dz/UniFAR-FTUs huggingface dataset:
Global trends of Vaccinia oncolytic virus therapy over the past two decades: Bibliometric and visual analysis

Background In recent years, the vaccinia oncolytic virus has entered the clinical trial stage of examination and shown good progress. It has many advantages, such as good safety, high oncolytic efficiency, and the regulation ability of the tumor microenvironment, and is expected to be successfully used in the clinical treatment of tumors in the future. However, no bibliometric analysis has so far been performed that generalizes horizontally across this field. Therefore, this study aims to assess the research status and trends in this field from a global perspective to help guide future research priorities. Methods In this study, the literature related to vaccinia oncolytic virus published in English on Web of Science from 2002 to 2022 was retrieved, and the bibliometric indicators were analyzed using the Histcite. Pro 2.0 tool, while VOSviewer was used to visualize the research trends and hotspots in this field. Results In total, 408 related studies were included. In the past 20 years, the number of related publications in this field has increased year by year, and breakthroughs were made in this field in 2008 and 2013. The research has grown rapidly since 2008, and will likely continue to expand in the years to come. The United States plays a leading role in this area. “MOLECULAR THERAPY-ONCOLYTICS”, “MOLECULAR THERAPY” and “JOURNAL OF TRANSLATIONAL MEDICINE” are core journals that publish high-quality literature on the latest advances in the field. Some authors with numerous high-quality publications include Bell JC and Szalay AA. At present, the research hotspot in this field focus on the clinical application of vaccinia oncolytic virus. Conclusion Overall, the number of vaccinia oncolytic virus-related studies is growing rapidly, in relation to which the United States is the most influential country. The clinical application of vaccinia oncolytic virus will affect the crucial development of future research.
Toward Understanding the Physiological Determinants of Microbial Competitiveness in Methanogenic Processes

Methanogenesis is of great significance in both natural and engineered processes. Anaerobic digestion technology represents the engineering-scale implementation of methanogenesis in waste treatment processes. Despite the broad application of anaerobic digestion as a common waste treatment option, much remains to be learned on the anaerobic food web underlying methanogenesis for more effective process modeling and control. Following an initial screening of various substrates, six continuous lab-scale anaerobic digesters were developed with animal waste as the substrate. The linkage between microbial community composition and process performance was studied by initiating process imbalance with organic overloading. As a result, accumulation of short chain fatty acids, particularly acetate, occurred in response to the onset of process imbalance. Populations related to Methanosaeta vastly outnumbered those of Methanosarcina as the dominant acetoclastic methanogen throughout the study period, even at elevated acetate concentrations during process imbalance, which is unexpected as it is considered that Methanosaeta can out-compete Methanosarcina only at low acetate concentrations, typical for balanced anaerobic food webs. Subsequent methanogenic batch cultures enriched with high concentrations of acetate further confirmed the dominance of Methanosaeta over Methanosarcina. Given the significance of acetoclastic methanogenesis in the anaerobic food web and global carbon cycling, it is evident that the interactions between Methanosaeta and Methanosarcina need to be better defined. Other novel microbial populations were also identified as abundant constituents of the microbial communities in the anaerobic digesters, including populations related to Crenarchaeota. It is critical to understand the roles these abundant but poorly-described populations play in the anaerobic food web.
ANÁLISE DA ESTRUTURA GENÉTICA DE POPULAÇÕES OVINAS CHURRAS PORTUGUESAS ANALYSIS OF GENETIC STRUCTURE OF PORTUGUESE SHEEP POPULATIONS FROM CHURRO BRANCH

and in the exotic Assaf breed, with a set of 20 microsatellite markers. Data were analyzed using the bayesian procedures implemented through the Structure software. The genetic variability observed suggests the existence of four ancestral populations which have originated them. The Assaf and Algarvia breeds are well identified with different ancestral populations, which is a result of their geographic distance relative to the other breeds. The remaining Churra breeds, which are exploited mostly in northern Portugal, show a low level of differentiation, and result from two ancestral populations which have contributed in some extent to each breed, indicating that probably some gene flow may have existed among them.
Differential neural reward reactivity in response to food advertising medium in children

Introduction Food cues including food advertisements (ads) activate brain regions related to motivation and reward. These responses are known to correlate with eating behaviors and future weight gain. The objective of this study was to compare brain responses to food ads by different types of ad mediums, dynamic (video) and static (images), to better understand how medium type impacts food cue response. Methods Children aged 9–12 years old were recruited to complete a functional magnetic resonance imaging (fMRI) paradigm that included both food and non-food dynamic and static ads. Anatomical and functional images were preprocessed using the fMRIPrep pipeline. A whole-brain analysis and a targeted region-of-interest (ROI) analysis for reward regions (nucleus accumbens, orbitofrontal cortex, amygdala, insula, hypothalamus, ventral tegmental area, substantia nigra) were conducted. Individual neural responses to dynamic and static conditions were compared using a paired t-test. Linear mixed-effects models were then constructed to test the differential response by ad condition after controlling for age, sex, BMI-z, physical activity, and % of kcal consumed of a participant’s estimated energy expenditure in the pre-load prior to the MRI scan. Results A total of 115 children (mean=10.9 years) completed the fMRI paradigm. From the ROI analyses, the right and left hemispheres of the amygdala and insula, and the right hemisphere of the ventral tegmental area and substantia nigra showed significantly higher responses for the dynamic food ad medium after controlling for covariates and a false discovery rate correction. From the whole-brain analysis, 21 clusters showed significant differential responses between food ad medium including the precuneus, middle temporal gyrus, superior temporal gyrus, and inferior frontal gyrus, and all regions remained significant after controlling for covariates. Discussion Advertising medium has unique effects on neural response to food cues. Further research is needed to understand how this differential activation by ad medium ultimately affects eating behaviors and weight outcomes.
Review of History Succession Planning: Replacement Planning, Talent Management and Workforce Planning

This study aimed to explores the issues and challenges of implementing succession planning in the Ministry of Education Malaysia. Besides that, this concept paper is also intended to look at factors that contribute to the implementation of an effective succession planning. The sample of this study is focused on the Education Service Officers, Ministry of Education Malaysia. The succession planning is seen as an important factor for the well-being of an organization. Transformational leadership, transactional leadership and organizational culture are seen as contributing factors to the implementation of effective succession planning. Thus the focus of this concept paper is to discuss in depth the research problem and the needs of succession planning implementation related to the contributing factors.
Promoting prosocial behavior in an unequal world

Amid a global pandemic and the climate crisis, there is an increasing need to understand how to promote largescale, coordinated action between different groups. Yet certain factors such as inequality can hinder cooperation. We aimed to establish how to orient groups toward a superordinate goal when they have unequal resources. Participants were divided into two ‘countries’ and asked to assemble LEGO bricks into food (by building pieces in a certain order) to prevent starvation among ‘the people’. One ‘country’ had few LEGO bricks whereas the other had an abundance, and the only way to maximize food creation was for the groups to work together. We assessed the efficacy of three diverse interventions on superordinate behavior and attitudes: compassion meditation training (Study 1), lower inequality (Study 2), and the introduction of a pro-sharing group norm by a confederate (Study 3). Compassion meditation training and altering the degree of inequality between groups did not have a clear effect on collaborative action. Only the introduction of a pro-sharing group norm enhanced sharing behavior, made participants feel more cooperative and reduced fears of being compassionate toward others. Our findings speak to the importance of leadership in promoting coordinated action to address challenges that face the superordinate group.
Evaluation of multiplex nanopore sequencing for Salmonella serotype prediction and antimicrobial resistance gene and virulence gene detection

In a previous study, Multiplex-nanopore-sequencing based whole genome sequencing (WGS) allowed for accurate in silico serotype prediction of Salmonella within one day for five multiplexed isolates, using both SISTR and SeqSero2. Since only ten serotypes were tested in our previous study, the conclusions above were yet to be evaluated in a larger scale test. In the current study we evaluated this workflow with 69 Salmonella serotypes and also explored the feasibility of using multiplex-nanopore-sequencing based WGS for antimicrobial resistance gene (AMR) and virulence gene detection. We found that accurate in silico serotype prediction with nanopore-WGS data was achieved within about five hours of sequencing at a minimum of 30× Salmonella genome coverage, with SeqSero2 as the serotype prediction tool. For each tested isolate, small variations were observed between the AMR/virulence gene profiles from the Illumina and Nanopore sequencing platforms. Taking results generated using Illumina data as the benchmark, the average precision value per isolate was 0.99 for both AMR and virulence gene detection. We found that the resistance gene identifier – RGI identified AMR genes with nanopore data at a much lower accuracy compared to Abricate, possibly due to RGI’s less stringent minimum similarity and coverage by default for database matching. This study is an evaluation of multiplex-nanopore-sequencing based WGS as a cost-efficient and rapid Salmonella classification method, and a starting point for future validation and verification of using it as a AMR/virulence gene profiling tool for the food industry. This study paves the way for the application of nanopore sequencing in surveillance, tracking, and risk assessment of Salmonella across the food supply chain.
Discrimination and learning of temporal input sequences in a cerebellar Purkinje cell model

Introduction Temporal information processing is essential for sequential contraction of various muscles with the appropriate timing and amplitude for fast and smooth motor control. These functions depend on dynamics of neural circuits, which consist of simple neurons that accumulate incoming spikes and emit other spikes. However, recent studies indicate that individual neurons can perform complex information processing through the nonlinear dynamics of dendrites with complex shapes and ion channels. Although we have extensive evidence that cerebellar circuits play a vital role in motor control, studies investigating the computational ability of single Purkinje cells are few. Methods We found, through computer simulations, that a Purkinje cell can discriminate a series of pulses in two directions (from dendrite tip to soma, and from soma to dendrite), as cortical pyramidal cells do. Such direction sensitivity was observed in whatever compartment types of dendrites (spiny, smooth, and main), although they have dierent sets of ion channels. Results We found that the shortest and longest discriminable sequences lasted for 60 ms (6 pulses with 10 ms interval) and 4,000 ms (20 pulses with 200 ms interval), respectively. and that the ratio of discriminable sequences within the region of the interesting parameter space was, on average, 3.3% (spiny), 3.2% (smooth), and 1.0% (main). For the direction sensitivity, a T-type Ca2+ channel was necessary, in contrast with cortical pyramidal cells that have N-methyl-D-aspartate receptors (NMDARs). Furthermore, we tested whether the stimulus direction can be reversed by learning, specifically by simulated long-term depression, and obtained positive results. Discussion Our results show that individual Purkinje cells can perform more complex information processing than is conventionally assumed for a single neuron, and suggest that Purkinje cells act as sequence discriminators, a useful role in motor control and learning.
Trefoil factor family proteins as potential diagnostic markers for mucinous invasive ovarian carcinoma

Introduction Ovarian cancer (OC) is the leading cause of gynecological cancer-related death. Of the main OC histologic subtypes, invasive mucinous carcinomas (MC) account for only 3% of OC cases and are frequently associated with favorable prognosis. Nevertheless, MCs differ greatly from the other OC histotypes in clinical, pathological, and biological behavior. However, the origin and molecular pathogenesis of MC are not yet fully understood. Therefore, identification of novel diagnostic markers could potentially facilitate early diagnosis of OC, particularly the MC histotype, thereby leading to the development of histotype-specific treatment regimens and improved survival rates. Methods In the present study, Trefoil factor gene family members (TFF1, TFF2 and TFF3) were identified as MC histotype-specific biomarkers using RNA sequencing (RNA-seq) data for 95 stage I-II OCs. The diagnostic value of TFF1, TFF2 and TFF3 was then evaluated by immunohistochemistry on 206 stage I-II OCs stratified by histotype (high-grade serous carcinoma [HGSC], endometrioid carcinoma [EC], clear cell carcinoma [CCC], and MC). Results We showed significantly elevated intracytoplasmic protein expression levels for TFF1, TFF2 and TFF3 in MC samples, thereby revealing an association between expression of Trefoil factor gene family members and the MC histotype. Taken together, these findings suggest that the TFF proteins may play a pivotal role in tumor initiation and progression for the MC histotype. Conclusion Taken together, these findings suggest that the TFF proteins may play a pivotal role in tumor initiation and progression for the MC histotype. Moreover, these novel histotype-specific diagnostic biomarkers may not only improve patient stratification of early-stage ovarian carcinomas but may also be candidates for the development of molecular targeted therapies.
Determination of corporate credit ratings : Vietnamese evidence

The global economies have been experiencing a process of rapid financial integration and globalization since the 1980s. Consequently, individual economies are increasingly under the influences of a wide range of factors at home and abroad, which generate not only more opportunities for trade and investment but also more risks for domestic firms. The twentieth century witnessed numerous, and in many cases, spectacular corporate default and insolvency cases in both the developed and emerging economies. The credit rating agencies have been playing an increasingly important role in the risk monitoring and risk management system, but recently, they were under criticism for failures in various
A Cytotoxic Diterpenoid from Croton Membranaceus, the Major Constituent of Anticancer Herbal Formulations Used in Ghana

Croton membranaceus is used by herbalists and traditional healers in Ghana for the management of various cancers, especially prostate cancers. A methanolic extract of the roots showed cytotoxic activities against two cancer cell lines, and bioassay-guided fractionation of this extract revealed that the cytotoxic activity resided mostly in the ethyl acetate fraction. Six compounds were isolated from this fraction, including a new furano-clerodane diterpenoid (1), for which the trivial name crotomembranafuran is suggested. This compound exhibited an IC50 value of 4.1 μg/mL (10.6 μM) against human prostate (PC-3) cells, providing some support for the traditional use of C. membranaceus in the treatment of cancers.
Human Resource Management Diffusion and Productivity Imbalances

In this study, we explore spatial variance in management practices and assess its potential contribution to regional imbalances in productivity. The research builds on a growing body of evidence which indicates that differences in management practices can account for a substantial share of cross-country differences in total factor productivity, and which identifies an important role for management practices in explaining differences in productivity between firms in the UK. We contribute to this literature by studying regional variation in HRM and related management practices using workplace-level (i.e. plant-level) data in Britain, taken from the Workplace Employment Relations Survey (WERS). We use these data to map spatial variance in HRM intensity in Britain. We then seek to account for that variance and, in doing so, establish whether regional variance in HRM can help to account for regional variance in productivity. This analysis is complemented by a comparative investigation of equivalent data for France, where levels of productivity and HRM are both higher and less dispersed.
PRECIPITATION AND CLIMATE VARIABLES: A STUDY OF ISLAMABAD CITY

The objective of this paper is to investigate the short and long run association, and causality among precipitation (dependent variable), and other climate parameters such as minimum and maximum temperature, wind speed, relative humidity, and atmospheric pressure (independent variables) for Islamabad city. The authors have considered the data set from July 2001 December 2017, and applied several econometrics techniques such as Augmented Dickey-Fuller, Vectors Auto regression, Multivariate cointegration, and Granger causality techniques to analyze the data. The findings of the study demonstrated a longterm association between precipitation, and minimum temperature, atmospheric pressure, relative humidity, and wind speed. Finally, the Granger causality revealed the one-way causal relationship from atmospheric pressure to the rainfall, rainfall to relative humidity, and atmospheric pressure to rainfall. However, the authors have observed two-way causality between precipitation and minimum temperature.
Biogenic Amines in Cheese and other Fermented Foods: A Review.

The biogenic amine content of various foods has been widely studied because of their potential toxicity. Biogenic amines, such as tyramine and β-phenylethylamine, have been proposed as the initiators of hypertensive crisis in certain patients and of dietary-induced migraine. Another amine, histamine, has been implicated as the causative agent in several outbreaks of food poisoning. Histamine poisoning is a foodborne chemical intoxication resulting from the ingestion of foods containing excessive amounts of histamine. Although commonly associated with the consumption of scombroid-type fish, other foods such as cheese have also been associated with outbreaks of histamine poisoning. Fermented foods such as wine, dry sausage, sauerkraut, miso, and soy sauce can also contain histamine along with other biogenic amines. Microorganisms possessing the enzyme histidine decarboxylase, which converts histidine to histamine, are responsible for the formation of histamine in foods. One organism, Lactobacillus buchneri , may be important to the dairy industry due to its involvement in cheese-related outbreaks of histamine-poisoning. The toxicity of histamine appears to be enhanced by the presence of other biogenic amines found in foods that can inhibit histamine-metabolizing enzymes in the small intestine. Estimating the frequency of histamine poisoning is difficult because most countries do not regulate histamine levels in foods, nor do they require notification when an incident of histamine poisoning occurs. Also, because histamine poisoning closely resembles a food allergy, it may often be misdiagnosed. This review will focus on the importance of histamine and biogenic amines in cheese and other fermented foods.
Superstorm Sandy exposure in utero is associated with neurobehavioral phenotypes and brain structure alterations in childhood: A machine learning approach

Introduction Prenatal maternal stress (PNMS), including exposure to natural disasters, has been shown to serve as a risk factor for future child psychopathology and suboptimal brain development, particularly among brain regions shown to be sensitive to stress and trauma exposure. However, statistical approaches deployed in most studies are usually constrained by a limited number of variables for the sake of statistical power. Explainable machine learning, on the other hand, enables the study of high data dimension and offers novel insights into the prominent subset of behavioral phenotypes and brain regions most susceptible to PNMS. In the present study, we aimed to identify the most important child neurobehavioral and brain features associated with in utero exposure to Superstorm Sandy (SS). Methods By leveraging an explainable machine learning technique, the Shapley additive explanations method, we tested the marginal feature effect on SS exposures and examined the individual variable effects on disaster exposure. Results Results show that certain brain regions are especially sensitive to in utero exposure to SS. Specifically, in utero SS exposure was associated with larger gray matter volume (GMV) in the right caudate, right hippocampus, and left amygdala and smaller GMV in the right parahippocampal gyrus. Additionally, higher aggression scores at age 5 distinctly correlated with SS exposure. Discussion These findings suggest in utero SS exposure may be associated with greater aggression and suboptimal developmental alterations among various limbic and basal ganglia brain regions.
LKPD Bentuk Molekul Berbasis Inkuiri Terstruktur Dengan Menggunakan Pemodelan Tiga Dimensi

This study is research and development (RD) and using 4-D models, but disseminate step is not done. Validation of student worksheets has been done by chemistry lecturers and chemistry teachers. The practicality of student worksheets has been done by chemistry teachers and students of 2nd grade of SMAN 1 Pariaman. The result showed that moment kappa average of validity was 0,83 with very high validity category and moment kappa average of practicality were 0,9 by chemistry teachers and 0,86 by students with very high category. Therefore student worksheets of molecular shape based on structured inquiry with emphasis on the submicroscopic level using 3-D models is valid and practice to be used on the chemistry learning.