Miracle-dz/UniFAR-FTUs huggingface dataset:
VLT-VIMOS integral field spectroscopy of luminous and ultraluminous infrared galaxies III. The atlas of the stellar and ionized gas distribution

Based on observations carried out at the European Southern observatory, Paranal (Chile), Programs 076.B- 0479(A), 078.B-0072(A) and 081.B-0108(A). The Digitized Sky Surveys were produced at the Space Telescope Science Institute under U.S. Government grant NAG W-2166.This work has been supported by the Spanish Ministry of Science and Innovation (MICINN) under grant ESP2007-65475-C02-01. AM-I is supported by the Spanish Ministry of Science and Innovation (MICINN) under program “Specialization in International Organisms”, Ref. ES2006-0003.
Planet signatures and effect of the chemical evolution of the Galactic thin-disk stars

Context: Studies based on high-precision abundance determinations revealed that chemical patterns of solar twins are characterised by the correlation between the differential abundances relative to the Sun and the condensation temperatures (Tc) of the elements. It has been suggested that the origin of this relation is related to the chemical evolution of the Galactic disk, but other processes, associated with the presence of planets around stars, might also be involved. Aims: We analyse HIRES spectra of 14 solar twins and the Sun to provide new insights on the mechanisms that can determine the relation between [X/H] and Tc. Methods: Our spectroscopic analysis produced stellar parameters (Teff, log g, [Fe/H], and $\xi$), ages, masses, and abundances of 22 elements (C, O, Na, Mg, Al, Si, S, K, Ca, Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Sr, Y, and Ba). We used these determinations to place new constraints on the chemical evolution of the Galactic disk and to verify whether this process alone can explain the different [X/H]-Tc slopes observed so far. Results: We confirm that the [X/Fe] ratios of all the species correlate with age. The slopes of these relations allow us to describe the effect that the chemical evolution of the Galactic disk has on the chemical patterns of the solar twins. After subtracting the chemical evolution effect, we find that the unevolved [X/H]-Tc slope values do not depend on the stellar ages anymore. However, the wide diversity among these [X/H]-Tc slopes, covering a range of $\pm$4~10$^{-5}$ dex K$^{-1}$, indicates that processes in addition to the chemical evolution may affect the [X/H]-Tc slopes. Conclusions: The wide range of unevolved [X/H]-Tc slope values spanned at all ages by our sample could reflect the wide diversity among exo-planetary systems observed so far and the variety of fates that the matter in circumstellar disks can experience.
Canine brucellosis in three littermates, case report

Three adult littermates were diagnosed with Brucella canis, two of which were diagnosed with discospondylitis. The first littermate, a 2-year-old spayed-female Labrador Retriever, was evaluated for progressive episodes of cervical pain, lethargy, reported circling to the right, and a right-sided head tilt. Magnetic resonance imaging (MRI) of the cervical spine revealed changes consistent with discospondylitis at C6-C7. MRI of the brain was unremarkable and cerebrospinal fluid analysis was declined. Brucella spp. was isolated from aerobic and Brucella blood cultures. PCR performed on the isolate identified Brucella canis and indirect fluorescent antibody (IFA) testing for Brucella canis also confirmed the species. Patient #1 was treated with doxycycline and marbofloxacin for 1 year. Clinical signs returned 2-years after diagnosis. Following the diagnosis of patient #1, a known littermate (patient #2) was tested for Brucella canis. Patient #2 was 2 years old and asymptomatic at the time of diagnosis. Aerobic and Brucella spp. cultures, PCR, and IFA were obtained and were diagnostic for Brucella canis. A 6-month course of marbofloxacin and doxycycline was implemented. The patient remained PCR positive following 4 months of treatment and repeat cultures were planned following 6 months of treatment; however, the patient was lost to follow-up. A third littermate (patient #3) was identified by the family of patient #1. Patient #3 was evaluated at 18 months of age for a 6-month history of progressive lumbosacral pain. Spinal radiographs revealed discospondylitis of the C3-C4, T12-T13, and L7-S1 vertebral endplates. Computed tomography (CT) of the lumbosacral spine was also consistent with discospondylitis at L7-S1. Brucella canis serologic testing consisting of rapid slide agglutination test, 2ME-rapid slide agglutination test, and cytoplasmic agar gel immunodiffusion was positive. Enrofloxacin was administered for 7 months and was discontinued thereafter based on radiographic evidence of healing and resolution of clinical signs. Although Brucella canis is not a rare disease in dogs, the documentation of two out of three adult littermates with associated discospondylitis is an interesting feature. In addition, this report highlights available diagnostic and treatment options, as each patient was managed differently based on clinical signs and the preference of the managing clinician.
Gut microbiome and metabolites: The potential key roles in pulmonary fibrosis

There are a wide variety of microbiomes in the human body, most of which exist in the gastrointestinal tract. Microbiomes and metabolites interact with the host to influence health. Rapid progress has been made in the study of its relationship with abenteric organs, especially lung diseases, and the concept the of “gut–lung axis” has emerged. In recent years, with the in-depth study of the “gut–lung axis,” it has been found that changes of the gut microbiome and metabolites are related to fibrotic interstitial lung disease. Understanding their effects on pulmonary fibrosis is expected to provide new possibilities for the prevention, diagnosis and even treatment of pulmonary fibrosis. In this review, we focused on fibrotic interstitial lung disease, summarized the changes the gut microbiome and several metabolites of the gut microbiome in different types of pulmonary fibrosis, and discussed their contributions to the occurrence and development of pulmonary fibrosis.
A novel cell senescence-related IncRNA survival model associated with the tumor immune environment in colorectal cancer

Long noncoding RNAs have a major role in tumorigenesis, development, and metastasis in colorectal cancer (CRC), participate in the regulation of cell senescence and are related to the prognosis of CRC. Therefore, it is important to validate cell senescence-related lncRNAs that correlate with prognosis in CRC. Methods CRC expression profile data and clinical information were downloaded from TCGA. A gene list related to cellular senescence was obtained from Human Aging Genomic Resources. A coexpression network of cell senescence-related mRNA−lncRNA was explored with R. Six cell senescence-related lncRNA signatures were identified by univariate and multivariate analyses. The cell senescence-related risk model was generated by using six cell senescence-related lncRNAs, and the risk score was calculated. Furthermore, an internal validation set and GSE17537 were used to verify the risk model. The risk model demonstrated good stability and accuracy. Finally, we investigated the correlation between cell senescence-related risk scores and immune infiltration, immune function, immune checkpoints, and drug sensitivity. Result We established a signature of six cell senescence-related lncRNAs. The cell senescence-related risk model revealed an exceptional ability to assess the prognosis of colorectal cancer and was correlated with clinical features. Additionally, we observed that risk models correlate with the tumor microenvironment and immune checkpoints, potentially predicting patient response to clinical immunotherapy. Finally, we validated the correlation between the cell senescence-related risk model and drug susceptibility. Our findings indicated that AICAR, cisplatin, nilotinib, and bexarotene exhibited lower IC50 values in the high-risk group. Conclusion Our current study identified 6 cell senescence-associated lncRNA signatures that may be vital biomarkers to predict the prognostic features and immune and chemotherapy responses in CRC.
Cybergenetic control of microbial community composition

The use of bacterial communities in bioproduction instead of monocultures has potential advantages including increased productivity through division of labour, ability to utilise cheaper substrates, and robustness against perturbations. A key challenge in the application of engineered bacterial communities is the ability to reliably control the composition of the community in terms of its constituent species. This is crucial to prevent faster growing species from outcompeting others with a lower relative fitness, and to ensure that all species are present at an optimal ratio during different steps in a biotechnological process. In contrast to purely biological approaches such as synthetic quorum sensing circuits or paired auxotrophies, cybergenetic control techniques - those in which computers interface with living cells-are emerging as an alternative approach with many advantages. The community composition is measured through methods such as fluorescence intensity or flow cytometry, with measured data fed real-time into a computer. A control action is computed using a variety of possible control algorithms and then applied to the system, with actuation taking the form of chemical (e.g., inducers, nutrients) or physical (e.g., optogenetic, mechanical) inputs. Subsequent changes in composition are then measured and the cycle repeated, maintaining or driving the system to a desired state. This review discusses recent and future developments in methods for implementing cybergenetic control systems, contrasts their capabilities with those of traditional biological methods of population control, and discusses future directions and outstanding challenges for the field.
Antimicrobial susceptibility to polymyxin B and other comparators against Gram-negative bacteria isolated from bloodstream infections in China: Results from CARVIS-NET program

Objective To investigate the bacterial distribution and antimicrobial resistance profile of clinical isolates from Gram-negative bacteria bloodstream infections (GNBSI) in China. Methods The clinical bacterial strains isolated from blood culture were collected during April 2019 to December 2021 in 21 member hospitals of China Bloodstream Gram-negative Pathogens Antimicrobial Resistance and Virulence Surveillance Network (CARVIS-NET). Antibiotic susceptibility test was conducted by broth microdilution method recommended by Clinical and Laboratory Standards Institute (CLSI, United States). WHONET 2021 and SPSS 22.0 were used to analyze data. Results During the study period, 1939 Gram-negative bacteria were collected from 21 hospitals, among which 1,724 (88.9%) were Enterobacteriaceae, 207 (10.7%) were non-fermenting Gram-negative bacteria and 8 (0.4%) were others. The top five bacterial species were Escherichia coli (46.2%), Klebsiella pneumoniae (31.6%), Pseudomonas aeruginosa (4.9%), Acinetobacter baumannii (4.2%) and Enterobacter cloacae (3.0%). For K. pneumoniae, antibiotic resistance was mainly prevalent in hospital-associated bloodstream infections, while for A. baumannii, antibiotic resistance was mainly prevalent in community-associated bloodstream infections. It is worth mentioning that 94.1% of the 1939 Gram-negative isolates were susceptible to polymyxin B. The sensitivity of the strains involved in our investigation to polymyxin B is highly correlated with their sensitivity to colistin. Conclusion The surveillance results in CARVIS-NET-2021 showed that the main pathogens of GNBSI in China were Enterobacteriaceae, while E. coli was the most common pathogen. The resistance rates of K. pneumonia, P. aeruginosa, A. baumannii, and E. cloacae to multiple antibiotics kept on a high level. In many cases, polymyxin B and colistin has become the last-resort agents to combat bloodstream infections caused by multidrug-resistant (MDR) Gram-negative bacteria.
Using implementation mapping to develop strategies for preventing non-communicable diseases in Japanese small- and medium-sized enterprises

Introduction Workplace programs to prevent non-communicable diseases (NCDs) in the workplace can help prevent the incidence of chronic diseases among employees, provide health benefits, and reduce the risk of financial loss. Nevertheless, these programs are not fully implemented, particularly in small- and medium-sized enterprises (SMEs). The purpose of this study was to develop implementation strategies for health promotion activities to prevent NCDs in Japanese SMEs using Implementation Mapping (IM) to present the process in a systematic, transparent, and replicable manner. Methods Qualitative methods using interviews and focus group discussions with 15 SMEs and 20 public health nurses were conducted in a previous study. This study applied the Consolidated Framework for Implementation Research and IM to analyze this dataset to develop implementation strategies suitable for SMEs in Japan. Results In task 2 of the IM, we identified performance objectives, determinants, and change objectives for each implementation stage: adoption, implementation, and maintenance; to identify the required actors and actions necessary to enhance implementation effectiveness. Twenty-two performance objectives were identified in each implementation stage. In task 3 of the IM, the planning group matched behavioral change methods (e.g., modeling and setting of graded tasks, framing, self-re-evaluation, and environmental re-evaluation) with determinants to address the performance objectives. We used a consolidated framework for implementation research to select the optimal behavioral change technique for performance objectives and determinants and designed a practical application. The planning team agreed on the inclusion of sixteen strategies from the final strategies list compiled and presented to it for consensus, for the overall implementation plan design. Discussion This paper provides the implementation strategies for NCDs prevention for SMEs in Japan following an IM protocol. Although the identified implementation strategies might not be generalizable to all SMEs planning implementation of health promotion activities, because they were tailored to contextual factors identified in a formative research. However, identified performance objectives and implementation strategies can help direct the next steps in launching preventive programs against NCDs in SMEs.
Atlas of monochromatic images of planetary nebulae

We present an atlas of more than one hundred original images of planetary nebulae (PNe). These images were taken in a narrow-band filter centred on the nebular emission of the [N ii] during several observing campaigns using two moderate-aperture telescopes, at the Complejo Astronomico El Leoncito (CASLEO), and the Estacion Astrofisica de Bosque Alegre (EABA), both in Argentina. The data provided by this atlas represent one of the most extensive image surveys of PNe in [N ii]. We compare the new images with those available in the literature, and briefly describe all cases in which our [N ii] images reveal new and interesting structures.
Stochastic gravitational wave background from hydrodynamic turbulence in differentially rotating neutron stars

Hydrodynamic turbulence driven by crust-core differential rotation imposes a fundamental noise floor on gravitational wave observations of neutron stars. The gravitational wave emission peaks at the Kolmogorov decoherence frequency which, for reasonable values of the crust-core shear, \Delta\Omega, occurs near the most sensitive part of the frequency band for ground-based, long-baseline interferometers. We calculate the energy density spectrum of the stochastic gravitational wave background from a cosmological population of turbulent neutron stars generalising previous calculations for individual sources. The spectrum resembles a piecewise power law, \Omega_{gw}(\nu)=\Omega_{\alpha}\nu^{\alpha}, with \alpha=-1 and 7 above and below the decoherence frequency respectively, and its normalisation scales as \Omega_{\alpha}\propto(\Delta\Omega)^{7}. Non-detection of a stochastic signal by Initial LIGO implies an upper limit on \Delta\Omega and hence by implication on the internal relaxation time-scale for the crust and core to come into co-rotation, \tau_{d}=\Delta\Omega/\dot{\Omega}, where \dot{\Omega} is the observed electromagnetic spin-down rate, with \tau_{d}\lesssim 10^{7} yr for accreting millisecond pulsars and \tau_{d}\lesssim 10^{5} yr for radio-loud pulsars. Target limits on \tau_{d} are also estimated for future detectors, namely Advanced LIGO and the Einstein Telescope, and are found to be astrophysically interesting.
Nutritional status and function after high-calorie formula vs. Chinese food intervention in undernourished children with cerebral palsy

Aim To investigate the efficacy and safety of high-calorie formula vs. Chinese daily food on the nutritional status and motor function of undernourished children with cerebral palsy (CP). Methods In this prospective, assessor-blind, and randomized controlled trial, we recruited children (1–10 years) with CP and undernutrition based on the WHO and the American Society for Parenteral and Enteral Nutrition criteria from the National Children's Medical Center. Participants were randomly allocated (1:1) to a high-calorie formula group or a Chinese daily food diet group (control group) for 6 months. Indirect calorimetry was used to estimate energy requirements. We compared the nutritional status and gross motor function of participants in both groups based on weight, height, z-scores (weight-for-age, height-for-age, weight-for-height, and BMI-for-age), and the Gross Motor Function Measure (GMFM), respectively, at baseline, 3-, and 6-months follow-up. In addition, the effective rate of nutritional intervention, and adverse events were simultaneously assessed. Results From July 2020 to December 2021, a total of 119 participants were enrolled and randomized, and 110 participants completed the study (with 54 children in the high-calorie formula group and 56 children in the control group). After 6 months of treatment, the weight, height, z-scores (weight-for-height, weight-for-age, and BMI-for-age), and GMFM of both groups were significantly improved (p < 0.05). There were significant differences in changes in weight, weight-for-age z-scores, and GMFM between the two groups (p < 0.05). During the study period, 16 children experienced at least one mild adverse event [9 (16.7%) in the formula group and 7 (12.5%) in the control group]. Conclusion Nutritional intervention with a high-calorie formula may be an effective and safe option in children with CP for improving undernutrition and gross motor dysfunction. Clinical trial registration www.chictr. org.cn, identifier: ChiCTR2000033878.
New mechanistic insights into the RAS-SIN1 interaction at the membrane

Stress-activated MAP kinase-interacting protein 1 (SIN1) is a central member of the mTORC2 complex that contains an N-terminal domain (NTD), a conserved region in the middle (CRIM), a RAS-binding domain (RBD), and a pleckstrin homology domain. Recent studies provided valuable structural and functional insights into the interactions of SIN1 and the RAS-binding domain of RAS proteins. However, the mechanism for a reciprocal interaction of the RBD-PH tandem with RAS proteins and the membrane as an upstream event to spatiotemporal mTORC2 regulation is not clear. The biochemical assays in this study led to the following results: 1) all classical RAS paralogs, including HRAS, KRAS4A, KRAS4B, and NRAS, can bind to SIN1-RBD in biophysical and SIN1 full length (FL) in cell biology experiments; 2) the SIN1-PH domain modulates interactions with various types of membrane phosphoinositides and constantly maintains a pool of SIN1 at the membrane; and 3) a KRAS4A-dependent decrease in membrane binding of the SIN1-RBD-PH tandem was observed, suggesting for the first time a mechanistic influence of KRAS4A on SIN1 membrane association. Our study strengthens the current mechanistic understanding of SIN1-RAS interaction and suggests membrane interaction as a key event in the control of mTORC2-dependent and mTORC2-independent SIN1 function.
Genetic diversity of juçara palm: An alternative for selection and conservation in cash crop for fruit production

The diversity of juçara palm (Euterpe edulis) must be investigated at the molecular level to enable the adoption of appropriate management strategies that may associate breeding studies with conservation. With the aim of describing the genetic diversity and structure of a population of E. edulis in a commercial plantation area, the genotyping of 199 individuals was performed using nine nuclear microsatellite markers. We detected inbreeding in the population and the diversity within the plots was high showing diversity among the individuals. The individuals from matrices germplasm of the locality Santa Marta, were divergent. The diversity indices observed in the studied population were close to those reported in the literature for natural populations; thus, the ex situ conservation of the population in this managed is feasible, as is their potential use in breeding studies.
Second Law in Classical Non‐Extensive Systems

Equilibrium statistics of Hamiltonian systems is correctly described by the microcanonical ensemble, whereas canonical ones fail in the most interesting, mostly inhomogeneous, situations like phase separations or away from the “thermodynamic limit” (e.g. self‐gravitating systems and small quantum systems) [1, 2, 3]. A new derivation of the Second Law is presented that respects these fundamental complications. Our “geometric foundation of Thermo‐Statistics” [3] opens the fundamental (axiomatic) application of Thermo‐Statistics to non‐diluted systems or to “non‐simple” systems which are not similar to ideal gases. Supprisingly, but also understandably, a so far open problem c.f. ref. [4] page 50 and page 72.
The effect of cognitive ability on academic achievement: The mediating role of self-discipline and the moderating role of planning

In this study, 572 secondary school students aged 15–18 years old stage were selected to study the effect of their cognitive ability and self-discipline and planning on academic achievement. Cognitive ability was classified into memory ability, representational ability, information processing ability, logical reasoning ability, and thinking conversion ability, and analyzed the effects of these five ability values on academic achievement. The mediating effect of self-discipline ability between cognitive ability and academic achievement was analyzed using structural equation modeling (SEM), and the moderating role of planning in the mediating effect was analyzed using planning as a moderating variable. The results showed that cognitive ability can have a significant positive effect on academic achievement, while self-discipline plays a partially mediating role between cognitive ability and academic achievement, and the moderating effect of Planning is significant in the second half of the mediating effect, i.e., the effect of self-discipline on academic achievement changes as the level of planning increases, and the mediating effect is stronger in the condition of higher planning, and the mediating model with moderating effect holds.