Miracle-dz/UniFAR-FTUs huggingface dataset:
1,2,4-Triazolyl-carboxylate-based MOFs incorporating triangular Cu(II)-hydroxo clusters: topological metamorphosis and magnetism.

Bifunctional 1,2,4-triazole-carboxylate ligands, an achiral 1,2,4-triazol-4-yl-acetic acid (trgly-H) and a chiral (d)-2-(1,2,4-triazol-4-yl)-propionic acid (d-trala-H), derived from the corresponding α-amino acid precursors revealed unique binding abilities in the construction of Cu(II)-coordination polymers composing discrete triangular [Cu3(μ3-OH)] clusters. A related series of MOFs, [Cu3(μ3-OH)(trgly)3(SO4)]·2H2O (1a), [Cu3(μ3-OH)(trgly)3(H2O)3]SO4·16H2O (1b), Cu3(μ3-OH)(d-trala)3(ClO4)0.5](ClO4)1.5·1.5H2O (2), was prepared, and their crystal structures were determined by means of X-ray diffraction. Being singly deprotonated, the organic ligands act as multidentate μ3- or μ4-donors using tr and -COO(-) moieties. The generated [Cu3(μ3-OH)(tr)3] cluster core is primarily supported by three [-N-N-] triazole heterocycles in a basal plane and tripodal-assisted μ3-anions (SO4(2-): 1a; ClO4(-): 2) capping the axial faces. The carboxylate groups join the units into either two-dimensional (2D) layer (1a, 2) or 3D zeolite-like networks (1b). Compound 1b represents the topology of α-Po (pcu: 4(12). 6(3)) and crystallizes in the noncentrosymmetric space group I4̅3m, in which the six-connected [Cu3(μ3-OH)] clusters and trgly self-assemble in an open-channel cubic array possessing ∼56% solvent-accessible volume. Upon slight thermal treatment (∼60 °C), the structure irreversibly shrinks to the nonporous 2D motif 1a that belongs to a uninodal (3,6) network type. In structure 2 (space group R32), due to the [-N-N-] triazole and 1,3-bidentate carboxylate binding mode, each organic ligand bridges three metal clusters affording cross-linking of two adjacent layers with the same (3,6) topology. The resultant 3,9-c net is novel and can be categorized as two-nodal with point symbol {4(18). 6(18)}{4(2). 6}3. Spin frustration and antisymmetric exchange effects, resulting in abnormally low g values in the S = 1/2 states, were observed in the magnetic properties and the EPR spectra.
Evaluation of Multiplex Flow Cytometric Opsonophagocytic Assays for Determination of Functional Anticapsular Antibodies to Streptococcus pneumoniae

ABSTRACT The determination of functional antipneumococcal capsular polysaccharide antibodies by sequential testing of pre- and postvaccination serum samples one serotype at a time is sample-intensive and time-consuming and has a relatively low throughput. We tested several opsonophagocytic assay (OPA) formats, including the reference killing method, a monovalent bacterium-based flow method, a trivalent bacterium-based flow method, and a tetravalent bead-based flow method using a panel of sera (4 prevaccination and 16 postvaccination, from healthy adults immunized with the 23-valent pneumococcal polysaccharide vaccine). The trivalent and tetravalent methods allow simultaneous measurements of opsonic antibodies to multiple pneumococcal serotypes. The trivalent bacterial-flow OPA had significant correlation to the reference OPA method and to a previously published flow cytometric OPA (r values ranged from 0.61 to 0.91, P < 0.05) for serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F. The tetravalent OPA had significant correlation to all OPA method formats tested (r values from 0.68 to 0.92, P < 0.05) for all seven serotypes tested. This tetravalent OPA is an alternative to other OPA methods for use during vaccine evaluation and clinical trials. Further, the flow cytometric multiplex OPA format has the potential for expansion beyond the current four serotypes to eight or more serotypes, which would further increase relative sample throughput while reducing reagent and sample volumes used.
Cutting mechanics: relation to performance and anterior cruciate ligament injury risk.

PURPOSE Quick changes of direction during running (cutting) are necessary for successful performance of many sports but are associated with noncontact anterior cruciate ligament (ACL) injuries. Currently, it is not known how biomechanics associated with fast performance of cutting tasks relate to the mechanics associated with increased risk for injury. Without this knowledge, the technique emphasized in injury prevention programs may be at odds with the demands of cutting tasks. The purposes of this study were to 1) identify whole body and/or joint mechanics that are related to completion times of 45° and 90° cuts and, from these variables, 2) determine which variables are predictors of performance (i.e., completion time) and/or ACL injury risk (i.e., peak knee adductor moment). METHODS Whole body and joint biomechanics were analyzed during the execution of two sidestep cutting maneuvers (to 45° and 90°) in 25 healthy experienced soccer players. Pearson correlation coefficients and stepwise multiple regression were used to analyze relations between variables. RESULTS The variables predictive of 45° cut performance included hip extensor moment and hip sagittal plane power generation as well as medial-lateral center-of-mass to center-of-pressure separation distance. This separation distance was also predictive of peak knee adductor moment. During the 90° cut, medial-lateral ground reaction force impulse and hip frontal plane power generation were predictive of performance whereas hip internal rotation and knee extensor moment were predictive of peak knee adductor moment. CONCLUSIONS These relations have important implications for ACL injury prevention programs. Although restricting frontal and transverse plane movement has been emphasized in many programs, these movement recommendations may not be appropriate for cutting tasks performed at greater angles.
Impact of the drift region profile on performance and reliability of RF-LDMOS transistors

In this paper, we study the influence of the doping profile in the drift region on performance and reliability of RF-NLDMOS transistors in a 0. 13µm SiGe-BiCMOS technology. Two different drift region designs were investigated by simulation and experiment. We show that the design with a shallow compensation implant delivers a significantly improved HCI robustness at a similar level of RF and DC performance. The presented modular integration concept offers NLDMOS devices with breakdown-voltages BVDSS=21 V and peak cut-off frequencies fT=23 GHz. The maximum operating voltage for less than 10% degradation of the on-resistance in ten years is 11 V.
Chipless RFID strain sensors: A novel feasibility analysis in terms of conventional patch antennas

This paper focuses on the design and feasibility analysis of conventional microstrip patch antennas as chipless RFID strain sensors. Three sensing antennas with different substrates are designed and their structural deformation due to different types of applied strain is theoretically analyzed. These theoretical deformation results are used to calculate the corresponding resonance frequency and quality factor deviation to determine the maximum amount of stress the antennas can tolerate. Thus a novel analysis is presented to determine the acceptability of the designed antennas as strain sensors.
HR-pQCT: a non-invasive ‘biopsy’ to assess bone structure and strength

One-third of children will sustain a fracture by the age of 17 years, and 25–35% of these will be of the distal forearm. There is evidence that childhood fractures are linked to underlying skeletal fragility.1 Low bone mineral density (BMD), measured by dual-energy X-ray absorptiometry (DXA), has been shown to be associated with increased fracture frequency in children;2 other factors, including vigorous activity, are associated with changes in bone microarchitecture.2–4 Early identification and treatment of children who are at increased risk of fracture may lead to the optimisation of bone health in later life.4 There are limited technologies used to investigate childhood bone health. Bone biopsy is limited due to its invasiveness, pain and general anaesthetic requirements. Most commonly, BMD is measured by DXA. A low BMD in children is defined as a Z-score of ≤ −2.0. 5 The site-specific Z-score uses a reference population of children who are age, sex and ethnicity matched. T-scores (adults) are not appropriate for children as they use the average peak BMD attained in early adulthood. The clinical relevance of a low BMD in childhood is not fully understood.2 However, it is accepted that children with a low BMD are at an increased risk of developing osteoporosis. The International Society of Clinical Densitometry in 2014 stated that in children “…the diagnosis of osteoporosis requires the presence of both a clinically significant fracture history and low BMD” . 6 A significant fracture history is …
Psychogenic Memory Deficits Associated with Functional Cerebral Changes: An fMRI Study

We studied a case of psychogenic amnesia by means of a functional magnetic resonance imaging (fMRI) experiment involving the retrieval of autobiographical memories. The 38-year-old patient was unable to access most of her autobiographical memories from her childhood up to 16 years of age. Compared with the forgotten period, evocation of the normally retrieved memories elicited increased activity in medial temporal and dorso–lateral frontal regions. Evocation of the preserved scattered recollections was associated with bilaterally distributed temporo-parieto-occipital loci of activations. These functional changes seem to support the idea of common mechanisms involved in both organic and psychogenic amnesias.
Factors controlling precision and accuracy in isotope-ratio-monitoring mass spectrometry.

The performance of systems in which picomole quantities of sample are mixed with a carrier gas and passed through an isotope-ratio mass spectrometer system was examined experimentally and theoretically. Two different mass spectrometers were used, both having electron-impact ion sources and Faraday cup collector systems. One had an accelerating potential of 10kV and accepted 0.2 mL of He/min, producing, under those conditions, a maximum efficiency of 1 CO2 molecular ion collected per 700 molecules introduced. Comparable figures for the second instrument were 3 kV, 0.5 mL of He/min, and 14000 molecules/ion. Signal pathways were adjusted so that response times were <200 ms. Sample-related ion currents appeared as peaks with widths of 3-30 s. Isotope ratios were determined by comparison to signals produced by standard gases. In spite of rapid variations in signals, observed levels of performance were within a factor of 2 of shot-noise limits. For the 10-kV instrument, sample requirements for standard deviations of 0.1 and 0.5% were 45 and 1.7 pmol, respectively. Comparable requirements for the 3-kV instrument were 900 and 36 pmol. Drifts in instrumental characteristics were adequately neutralized when standards were observed at 20-min intervals. For the 10-kV instrument, computed isotopic compositions were independent of sample size and signal strength over the ranges examined. Nonlinearities of <0.04%/V were observed for the 3-kV system. Procedures for observation and subtraction of background ion currents were examined experimentally and theoretically. For sample/ background ratios varying from >10 to 0.3, precision is expected and observed to decrease approximately 2-fold and to depend only weakly on the precision with which background ion currents have been measured.
Probing the Specificity of Human Myeloma Proteins with a Random Peptide Phage Library

Human myeloma proteins (HMPs) from 10 patients with multiple myeloma (MM) were used to affinity‐select peptides from a random phage‐display peptide library. Binding peptides were identified for the 10 analysed antibodies (eight, immunoglobulin G (IgG), and two, immunoglobulin A (IgA)). The specificity of the binding was confirmed by competitive experiments using phages and chemically synthesized peptides. Interestingly, some phage‐displayed peptides were immuno‐selected with HMPs isolated from different patients. Sequence alignments and homology searches revealed a significant homology with human proteins (e.g. neural cell adhesion proteins) and pathogen‐derived proteins (e.g. herpes simplex virus capsid proteins). The selected peptides could be useful as targeting agents for myeloma cells expressing surface immunoglobulins.
Endotoxin-Binding Affinity of Sevelamer Hydrochloride

Background: Sevelamer hydrochloride has been shown to attenuate circulating biomarkers of inflammation in patients with chronic kidney failure. We hypothesize that sevelamer hydrochloride binds bacterial endotoxin (ET) resulting in a decrease in ET levels and cytokine production. Methods: To assess the ET-binding affinity of sevelamer hydrochloride, purified Escherichia coli ET was incubated with sevelamer hydrochloride (0–50 mg/ml). After incubation, ET was measured in supernatants. In addition, THP-1-derived monocytes were co-incubated with supernatants of sevelamer hydrochloride and ET. After 24-hour incubation, TNF-α was measured. The effect of pH on the ET-binding affinity of sevelamer hydrochloride, as well as cooperative binding between ET and phosphate for sevelamer hydrochloride were assessed. Results: Sevelamer hydrochloride exhibited time- and dose-dependent binding affinity for ET, resulting in a marked reduction in free ET levels. The 1-hour dose-dependent ET-binding effect of sevelamer hydrochloride translated into a marked reduction in TNF-α levels. Varying the pH conditions did not affect the ET-binding affinity of sevelamer hydrochloride. The addition of phosphate (0–50 mM) resulted in a further reduction in free ET levels, translating into a further increase in the binding affinity of sevelamer hydrochloride for ET. Conclusions: This study demonstrates that sevelamer hydrochloride binds to ET, thereby reducing free ET and cytokine levels. Positive cooperative binding was also noted between phosphate and ET for sevelamer hydrochloride. This study supports the hypothesis that sevelamer hydrochloride might bind to ET in the intestinal lumen and reduce systemic inflammation. Animal and human studies are required to examine this hypothesis.
A selective ARQ protocol with a finite-length buffer

Of the automatic-repeat-request (ARQ) techniques commonly used in communication systems, selective protocols, while the most efficient, have the notable drawback of requiring large buffers at the receiver side. A selective ARQ protocol with a finite-length buffer is described. If N is the number of codewords transmittable in the round-trip delay, the protocol requires a buffer length N+N/sub a/, N/sub a/>or=2 being an integer. A lower bound on the throughput of the protocol is derived. It achieves higher throughputs than similar schemes giving results comparable to those for selective protocols with infinite-length buffer for high error rates in the communication channel. >
Safety Performance Factor

Workplace safety performance is computed using frequency rate (FR) and severity rate (SR). Only work time lost due to occupational incidents that need to be reported is counted. FR and SR are the 2 most important safety performance indicators that are applied universally; however, calculations differ from country to country. All injuries and time lost should be considered while calculating safety performance. The extent of severity does not matter as every incident is counted. So, a new factor has to be defined; it should be based on the hours or days lost due to each occupational incident, irrespective of its severity. The new safety performance factor is defined as the average human-hour unit lost due to occupational accidents/incidents, including fatalities, first-aid incidents, bruises and cuts. The formula is simple and easy to apply.
Embracing Digital Innovation in Incumbent Firms: How Volvo Cars Managed Competing Concerns

Past research provides instructive yet incomplete answers as to how incumbent firms can address competing concerns as they embrace digital innovation. In particular, it offers only partial explanations of why different concerns emerge, how they manifest, and how firms can manage them. In response, we present a longitudinal case study of Volvo Cars'connected car initiative. Combining extant literature with insights from the case, we argue that incumbent firms face four competing concerns—capability (existing versus requisite), focus (product versus process), collaboration (internal versus external), and governance (control versus flexibility)—and that these concerns are systemically interrelated. Firms must therefore manage these concerns cohesively by continuously balancing new opportunities and established practices.
PLANTS WITH ANTIDIABETIC ACTIVITIES AND THEIR MEDICINAL VALUES

The anti - diabetic d rugs from plants in current clinical use and their similar mechanism of action of herbal components are preferred mainly due to lesser side effects and low cost. So many medicinal plants with anti - diabetic activity related beneficial effects and of herbal drugs used in diabetes is pressurized . The present review focused on the some of the herbal plants and their medicinal uses have shown experimental or clinical anti - diabetic activity. The essential values of some plants have long been published, but a larg e number of them have remained unexplored to date. Therefore, there is a necessity to explore their uses and to ascertain their therapeutic properties. These are mainly Allium cepa, Anacardium occidentale, Andrographic paniculata, Momordica charantia, Azad irakta indica, Brassica oleraccia, Cinnamomum tamala and Withania sominifera mainly etiological factor implicated in the development of diabetes and it's complications .
E-government public-private partnerships: the "Gorod" payments system in Siberia

Purpose – To examine and draw lessons from the experience of creating and implementing a unique e‐government payments system (“Gorod”) in a little‐studied area of the world.Design/methodology/approach – An interpretivistic methodology is used based on interviews of system developers, discussion forums, collection and tabulation of Gorod web site data, and contemporaneous sources.Findings – Gorod permits hundreds of thousands of citizens in about 25 Siberian cities to make in‐person or electronic payments on a single, unified bill to a wide range of public and private service suppliers. While Gorod does improve municipal payments collections, cities where banks run Gorod have been less successful than those with more neutral public‐private partnerships.Research limitations/implications – Diffusion of innovation theory (DIT) provides a useful framework for examining a system at this level of granularity.Practical implications – By joining public and private activities in one system, and by creating an infra.
A novel DC loop current control strategy for paralleled UPS inverter system based on decoupled control scheme

This paper proposes a novel Control strategy based on decoupled control scheme to eliminate DC loop current of paralleled uninterrupted power supply (UPS) inverter system. On the basis of the original paralleled system for load-sharing by active and reactive power control, a separate control circuit is added in each parallel inverter module to eliminate the DC component of output voltage. The voltage between the middle point of half bridge of inverter and the middle point of the DC bus capacitors is measured to accurately detect DC voltage offset of the inverter. Therefore, the DC component of each inverter output voltage can be regulated to zero. The method is based on the idea that DC voltage offset of each inverter is decoupled. Because each module only regulates its own DC voltage component, the DC Loop current control is decoupled. The experiment results in paralleled three-phase UPS inverter system verified the feasibility and reliability of the control strategy.
OPTICAL SYSTEM FOR MEASUREMENT OF SURFACE FORM AND ROUGHNESS Cz

Abstract: An optical system designed for measurement of surface form and roughness is the subject of this paper. The systems operation is based on the light scattering from surface irregularities. This system can be used for controlling the rough surfaces of objects under static conditions and while their movement. Measurement of form and surface waviness requires steady-rate displacement of the measuring setup with respect to the object. The principle of the systems operation and experimental results obtained from various machined rough surfaces are presented.
ENCRYPTION DEVICE USING RADIOACTIVE DECAY AND A HYBRID QUANTUM ENCRYPTION ALGORITM

Quantum computers are the future in computing as data encoded in modern computers is limited by the space to store it. Quantum computers encode data in atoms that don’t follow classical physics but rather quantum physics. Quantum physics provide an advantage in computing, as it allows data to be processed exponentially faster. However, increases in speed of such magnitude pose a risk to modern day encryption standards. Thus, to protect the transfer of data one must look towards developing innovative ways of encryption that shields it from the speed of quantum computers. This paper discusses a method to secure information using radioactive decay in conjunction with an encryption algorithm. The main purpose of this paper is to develop and implement an encryption device that can be interfaced with a computer system. The device then utilizes the randomness of radioactive decay as a seed used in the encryption algorithm.
Transmission characteristics of a thin metal film sandwiched between dielectric gratings

In this paper, we discuss the relation between the high transmissivities and these resonances in more detail. It is revealed that the high transmissivity based on the FPR is determined by the grating thickness, while the GMR and SPR by the periodicity. On the basis of these results, we design the polarizer which operates at a required wavelength by changing the periodicity. A high transmissivity of more than 85% is observed at each of the resonances.
Localization of Caveolin 1 in Aortic Valve Endothelial Cells Using Antigen Retrieval

Ultrastructural analysis of aortic valve endothelial cells subjected to growth arrest revealed many vesicles defined as caveolae by the localization of caveolin. Translocation of caveolin after exposure to oxidized LDL suggests that the localization of caveolin may be a valuable tool to study models of early atherogenesis. In this study, several antigen retrieval protocols were tested in osmium-fixed and Spurr-embedded cells to determine the optimal method of antigen retrieval in our model system. SDS produced the most consistent labeling pattern. A quantitative evaluation revealed that SDS significantly increased the labeling density in Spurr-embedded cells. The labeling pattern appeared as clusters of gold particles, 15–40 nm in diameter, that were associated with membranes of a similar size which may represent the neck region of the caveolae.
The DWF4 Gene of Arabidopsis Encodes a Cytochrome P450 That Mediates Multiple 22α-Hydroxylation Steps in Brassinosteroid Biosynthesis

dwarf4 (dwf4) mutants of Arabidopsis display a dwarfed phenotype due to a lack of cell elongation. Dwarfism could be rescued by the application of brassinolide, suggesting that DWF4 plays a role in brassinosteroid (BR) biosynthesis. The DWF4 locus is defined by four mutant alleles. One of these is the result of a T-DNA insertion. Plant DNA flanking the insertion site was cloned and used as a probe to isolate the entire DWF4 gene. Sequence analysis revealed that DWF4 encodes a cytochrome P450 monooxygenase with 43% identity to the putative Arabidopsis steroid hydroxylating enzyme CONSTITUTIVE PHOTOMORPHOGENESIS AND DWARFISM. Sequence analysis of two other mutant alleles revealed deletions or a premature stop codon, confirming that DWF4 had been cloned. This sequence similarity suggests that DWF4 functions in specific hydroxylation steps during BR biosynthesis. In fact, feeding studies utilizing BR intermediates showed that only 22α-hydroxylated BRs rescued the dwf4 phenotype, confirming that DWF4 acts as a 22α-hydroxylase.