Miracle-dz/UniFAR-FTUs huggingface dataset:
Repression of Smad‐dependent transforming growth factor‐β signaling by Epstein‐Barr virus latent membrane protein 1 through nuclear factor‐κB

EBV‐encoded LMP‐1 is absolutely required for EBV transformation of cells. Previous studies showed that LMP‐1 is responsible for mediating resistance to the anti‐proliferative effects of TGF‐β that characterizes EBV‐transformed cells. To clarify the mechanisms of resistance to TGF‐β by LMP‐1, we examined the effect of expression of LMP‐1 on the activity of TGF‐β‐responsive promoters. Interestingly, LMP‐1 inhibited TGF‐β‐responsive promoters activity despite lack of direct interaction of LMP‐1 and Smad proteins, intracellular signaling molecules in the TGF‐β signal transduction pathway. Although TGF‐β treatment increased the expression of p15, TGF‐β‐induced gene, this effect was counteracted by expression of LMP‐1. The repressive effect was mapped to the NF‐κB activation domains in the cytoplasmic carboxyl terminus of LMP‐1. Furthermore, LMP‐1‐mediated inhibition of TGF‐β‐responsive promoter was markedly restored after inhibition of NF‐κB activity. LMP‐1 failed to affect receptor‐dependent formation of heteromers containing Smad proteins as well as the DNA‐binding activity of Smad proteins. Overexpression of the transcriptional coactivator CBP and p300 abrogated the inhibitory effect of LMP‐1 on the TGF‐β‐responsive promoter. Our results suggest that LMP‐1 represses the TGF‐β signaling through the NF‐κB signaling pathway at transcriptional level by competing for a limited pool of transcriptional coactivators. These results enhance our understanding of the molecular mechanisms of viral pathogenesis in EBV‐associated malignancies. © 2003 Wiley‐Liss, Inc.
Learning Improvement Heuristics for Solving Routing Problems

Recent studies in using deep learning (DL) to solve routing problems focus on construction heuristics, whose solutions are still far from optimality. Improvement heuristics have great potential to narrow this gap by iteratively refining a solution. However, classic improvement heuristics are all guided by handcrafted rules that may limit their performance. In this article, we propose a deep reinforcement learning framework to learn the improvement heuristics for routing problems. We design a self-attention-based deep architecture as the policy network to guide the selection of the next solution. We apply our method to two important routing problems, i.e., the traveling salesman problem (TSP) and the capacitated vehicle routing problem (CVRP). Experiments show that our method outperforms state-of-the-art DL-based approaches. The learned policies are more effective than the traditional handcrafted ones and can be further enhanced by simple diversifying strategies. Moreover, the policies generalize well to different problem sizes, initial solutions, and even real-world data set.
Population dynamic principles

Although the causes of population extinction, locally and globally, are many, varied and idiosyncratic when individual species are considered, there are nevertheless some basic general constraints and ground rules that make some species more extinction-prone than others. This paper reviews their implications for the ultimate and proximate causes of extinction. Phenomena reviewed include: a positive correlation between local abundance and size of geographic range, putting some populations in ‘double jeopardy’; smaller average range sizes in the tropics; metapopulation dynamic processes that can spread risk, but only if the spatial correlation between fluctuations of conspecific populations is low; the influence of body size and trophic position; and phylogenetic constraints on range sizes and abundance.
Quality Evaluation of Grated Graviera Cheese Stored at 4 and 12°C using Active and Modified Atmosphere Packaging

The effect of active [oxygen absorber (OA) combined with an ethanol emitter (EE)] and modified atmosphere (100% Nitrogen) packaging in combination with a high barrier experimental polyethylene terephthalate‐silicon oxides//low density polyethelene film on shelf‐life extension of grated Graviera cheese stored at 4 and 12°C was investigated. Microbiological (total viable counts, Pseudomonads, lactic acid bacteria, Enterobacteriaceae and Yeasts/Moulds), physico‐chemical (pH, thiobarbituric acid and colour) and sensory (odour and taste) changes occurring in the product were monitored as a function of treatment and storage time (10 weeks). Sensory shelf‐life was approximately 1, 1.5, 4.5, 6, 9 and at least 10 weeks for control samples (12 and 4°C), for N2 packaged samples (12 and 4°C) and samples packaged with the OA + EE (12 and 4°C), respectively. At the point of sensory rejection, yeasts and moulds increased from 2.00 to 3.60 and 5.55 log CFU/g for control samples stored at 4 and 12°C, respectively. Similarly, for samples stored under nitrogen, yeasts and moulds reached 2.00 and 2.32 log CFU/g at 4 and 12°C, respectively. Yeasts and moulds in samples with the OA + EE remained below 2 log CFU/g throughout the entire storage period, irrespective of storage temperature. pH varied between 5.72 and 6.49 depending on specific treatment. Malondialdehyde absorbance ranged between 0.05 for fresh samples and 0.79 mg/kg at the time of sensory rejection of samples. Light parameters L and b decreased while parameter a increased during storage, reflecting a gradual discolouration of all samples and especially those stored at 12°C.
Normalization for cDNA microarry data

There are many sources of systematic variation in microarray experiments which affect the measured gene expression levels. Normalization is the term used to describe the process of removing such variation, e.g. for differences in labeling efficiency between the two fluorescent dyes. In this case, a constant adjustment is commonly used to force the distribution of the log-ratios to have a median of zero for each slide. However, such global normalization approaches are not adequate in situations where dy biases can depend on spot overall intensity and location on the array (print-tip effects). This paper describes normalization methods that account for intensity and spatial dependence in the dye biases for different types of cDNA microarray experiments, including dye-swap experiments. In addition, the choice of the subset of genes to use fo normalization is discussed. The subset selected may be different for experiments where only a few genes are expected to be differentially expressed and those where a majority of genes are expected to change. The proposed approaches are illustrated using gene expression data from a study of lipid metabolism in mice.
Morphological reply to a DNA call: a new cryptic species of Hydraena from western Europe, with a complete overview of the Hydraena gracilis complex (Coleoptera: Hydraenidae: “Haenydra” lineage)

Recent molecular analyses revealed unexpected genetic variability within Hydraena gracilis, one of the most common and widespread European moss beetles, belonging to the West Palaearctic endemic “Haenydra” lineage. For this taxon, molecular data univocally evidenced two distinct clades, the first one including populations from the Iberian Peninsula, and the second including populations from central and eastern Europe. Aedeagal morphology of H. gracilis was further investigated, finally demonstrating the actual existence of a new cryptic species of the H. gracilis complex in Portugal, Spain and the French Pyrenees. The geographical range of the true H. gracilis was consequently revised. Finally, dichotomous keys for males of all species belonging to the H. gracilis complex, and for males of all the Iberian “Haenydra” species, are also supplied.
Determination of nitrite and nitrate in meat products

A rapid method, of improved accuracy, for the determination of nitrate and nitrite in meat products is described. Nitrate is determined by reduction to nitrite with cadmium, and subsequent development of the dye Orange I obtained with I-naphthol/sulphanilic acid reagent. Nitrite present does not interfere and is separately determined with the same colorimetric reagent. In meat, a range of concentrations of nitrate and nitrite up to the equivalent of 2000 p.p.m. sodium nitrite may be determined.
Plant-mediated lipolysis and proteolysis in red clover with different polyphenol oxidase activities

Lee, M. R. F. , Winters, A. L. , Scollan, N. D. , Dewhurst, R. J., Theodorou, M. K. , Minchin, F. R. (2004). Plant mediated lipolysis and proteolysis in red clover with different polyphenol oxidase activities. Journal of the Science of Food and Agriculture, 84, (13), 1639-1645. Sponsorship: EC Healthybeef QLRT-2000-31423 / DEFRA
Influence of layer thickness and 3D printing direction on tensile properties of ABS material

The 3D printing process is a kind of additive manufacturing, that the basic principle of this process is adding material layer by layer to form a product. The purpose of this research was to study tensile properties of 3D printing ABS (Acrylonitrile Butadiene Styrene) material with axial and lateral direction. The specimen was printed according to ASTM D 632-02 by layer thickness variation around 0.1 mm, 0.2 mm and 0.3 mm. Moreover, three specimens were made for each printing axial and lateral direction. Tensile test was performed using Zwick Roell Series Z 021 machine. Then, the fracture surface was studied by SEM testing used ZEOL JSM-6510LA. Based on the research from 6 variation layer of 3D printing, the optimal result was found on the axial direction of 0.3 mm thickness layer with tensile strength 30.60 MPa and able to receive maximum load 551.13 N. The lateral direction of 0.3 mm thickness layer has tensile strength 19.42 MPa and able to receive maximum load 349.12 N. The voids were seen at the fracture surface of specimen.
SIMULATION OF HEAVY RAINFALL EVENT DURING 30/10 - 01/11/2008 OVER HANOI BY WRF MODEL

In urban areas, flooding can be very serious due to high population density and important infrastructure. As rainfall data at high temporal and spatial resolutions are required as input for urban flooding forecast, in this study, the Weather Research and Forecasting model (WRF) with four nests, two-way interaction is used to simulate the heavy rainfall event in Hanoi from 30/10/2008 01/11/2008 to investigate model ability on generating rainfall data on high temporal and spatial resolutions. The horizontal resolutions of the four nets are 27 km, 9 km, 3 km and 1 km. Two model experiments are performed including: (1) model inputs are poorly from reanalysis data only (CTRL) and (2) model input in CTRL is modified with JMA satellite radiance data in deep convective cloud regions (WSAT). The results showed that without satellite data assimilation, event with initial conditions from the best available analysis data, the WRF failed to capture observed heavy rainfall in many cases. With enhancement of initial conditions by satellite data, although there are some overestimated rainfall, the model can reasonably reproduce observed heavy rainfall amount over Hanoi region. Keyword: WRF model, heavy rainfall, satellite data.
Interactive effects of landscape and weather on dispersal

Over the last decades, many species have been forced to track their shifting climate envelopes, and at the same time man-induced landscape fragmentation has led to the global decrease of natural habitat availability and connectivity. The interaction between these two co-occurring global environmental changes might have very strong effects on biodiversity that are still understudied. Species-specific responses to these environmental changes critically depend on individual dispersal, either to track suitable climatic conditions or to cope with landscape fragmentation. Here we study how dispersal in an ectotherm is affected by interactions between landscape fragmentation and weather conditions. We show that both the emigration rates out of suitable habitats and the topology of the trajectory of dispersing individuals were affected by temperature and landscape fragmentation. The emigration rate was temperature-dependent in fragmented landscapes, with butterflies emigrating more at high temperatures. The emigration rate was temperature insensitive in more continuous landscapes. Move length was farther at low temperatures and less at high temperatures in fragmented landscapes. Move length was less at low temperatures and farther at high temperatures in more continuous landscapes. To our knowledge only two recent studies have documented patterns of interactions between climate and fragmentation, despite the fact that they are the two main drivers of biodiversity loss worldwide. Here, we go a step further by providing mechanistic explanations to such patterns.
Effects of Teacher Support on College Students' Math Achievement: The Mediating Effects of Basic Psychological Needs and Extrinsic Motivation

This paper investigated the effects of teacher support on college students’ math achievement. The sample included 1,176 college students from a local university in Guangdong Province, China. Guided by self-determination theory, college students’ basic psychological needs and extrinsic motivation were measured with three metrics including a basic psychological need scale, a learning motivation scale, and a teacher support scale. The results indicated that: (1) Liberal arts and science students had significant differences in their perceptions about teacher support and relationship support; (2) Teacher support had a positive predictive effect on college students' math achievement; (3) Basic psychological needs and extrinsic motivation played a mediating role between teacher support and college students' math achievement; and (4) The mediating effect of extrinsic motivation on students’ math achievement was greater than students’ basic psychological needs.
Warming promotes cold‐adapted phytoplankton in temperate lakes and opens a loophole for Oscillatoriales in spring

The effects of the recent warming trend in many northern temperate lakes on the species composition of spring phytoplankton remain poorly understood, especially because a recent change in nutrients has complicated efforts, and previous studies have defined spring according to the calendar. We analysed data from 1979 to 2004 from Lake Müggelsee (Berlin, Germany), using physical and biological parameters to define the spring period. We show that a change in timing of spring plankton events in warm years led to the paradox of lower mean water temperatures during the growth period, favouring cold‐adapted diatoms over cyanobacteria, and within the diatoms, some cold‐adapted centric forms over pennate forms. Under high P : Si ratios, the increased time between phytoplankton and cladoceran peaks opened a loophole for filamentous cyanobacteria (Oscillatoriales) in warm years to establish dominance after the diatoms, which are silicate limited. Therefore, the warming trend promotes filamentous cyanobacteria, a well‐known nuisance in eutrophic lakes, and surprisingly, cold‐adapted diatoms.
A state-of-the-art review on torque distribution strategies aimed at enhancing energy efficiency for fully electric vehicles with independently actuated drivetrains

© 2019, Levrotto and Bella. All rights reserved. Electric vehicles are the future of private passenger transportation. However, there are still several technological barriers that hinder the large scale adoption of electric vehicles. In particular, their limited autonomy motivates studies on methods for improving the energy efficiency of electric vehicles so as to make them more attractive to the market. This paper provides a concise review on the current state-of-the-art of torque distribution strategies aimed at enhancing energy efficiency for fully electric vehicles with independently actuated drivetrains (FEVIADs). Starting from the operating principles, which include the "control allocation" problem, the peculiarities of each proposed solution are illustrated. All the existing techniques are categorized based on a selection of parameters deemed relevant to provide a comprehensive overview and understanding of the topic. Finally, future concerns and research perspectives for FEVIAD are discussed.
Wybrane aspekty oceny satysfakcji z życia pielęgniarek oddziałów neurologicznych

Introduction . Satisfaction is a positive feeling, perceived subjectively. Assessment of life satisfaction is undertaken by comparing your own situation with the standards you set, your goals, objectives. Therefore, the measurement of satisfaction is based on individual criteria specific to each person. Aim . The study aims to determine satisfaction with life among nurses working in neurological wards. Material and Methods . The study was conducted in a group of 130 nurses working in neurological wards of hospitals in the Lublin Province. The vast majority of the study group constituted women (93.80%). Most respondents were aged between 36–50 years old (43.08%). The research used a standardized research tool: The Satisfaction with Life Scale (SWLS). Results . The examined group of neurological nurses assessed their satisfaction with life at an average level (20.66 ± 5.72 points). After converting points into sten values, the average was 5.56 ± 2.03 sten. Significant statistical differences in the assessment of life satisfaction were found in the material situation. The higher assessment was provided by nurses who were satisfied with their financial situation (21.70 points). Conclusions . The assessment of satisfaction with life among neurological nurses was at an average level. Self-assessment of the financial situation significantly differentiated the assessment of life satisfaction in the group of surveyed nurses. (JNNN 2019;8(4):157–161)
Corporate Venture Capital, Disclosure, and Financial Reporting

We examine firms’ corporate venture capital (CVC) investing activities from a disclosure and financial reporting perspective. The CVC industry has matured to become a driving force for innovation in today’s corporate landscape, yet there is very little research from accounting scholars. We document the type of details that firms provide about their CVC activities, as well as show that they tend to disclose fewer details when they invest in industries outside their own core business. We also document that firms with a CVC program, relative to similar firms without a CVC program, tend to make more future acquisitions and report an increased number of product segments but are not more likely to have future write-offs of goodwill and intangible assets. Our findings suggest firms with a CVC program have more awareness of and access to acquirable technologies and that CVC investing has a positive impact on firms’ future financial reporting.
Assessing the suitability of wetlands for the reintroduction of the Growling Grass FrogLitoria raniformis

The Growling Grass Frog Litoria raniformis has undergone population declines throughout its range over the past 20 years and is listed as a threatened species both in Victoria and nationally. The species was last recorded in 1979 in the area now occupied by the Portland Aluminium Smelter in southwestern Victoria, but the reasons for its disappearance from the area are unclear. Approximately 50 wetlands remain in the buffer zone of the smelter and we investigated the suitability of 20 of these wetlands for the reintroduction of the species. We measured a set of habitat parameters at the smelter (Smelter sites) and at five wetlands in south-western Victoria that had recent records of Growling Grass Frogs (Extant sites). Discriminant function analysis identified a number of variables that discriminated between Extant and Smelter sites, particularly the extent of algae and the percentage of shoreline covered by bare ground, by short terrestrial vegetation and by other cover types. We recommend the planting of.
Polyamines are involved in the gynogenesis process in onion

Haploidization in onion (Allium cepa L.) using immature flower buds simulates zygotic embryogenesis with no fecundation. In order to know the involvement of polyamines (PAs) in this process, we determined the concentration of endogenous PAs in flower buds and experimented the addition of various combinations of PA molecules in the medium. At the inoculation stage, high levels of free and conjugated spermidine and low putrescine + hydroxyputrescine/spermidine + spermine ratio characterized the highest responsive varieties. During in vitro culture, high levels of putrescine and its derivatives characterized the lowest responsive varieties, whereas high levels of spermidine and spermine characterized responsive varieties. The putrescine + hydroxyputrescine + homospermidine/spermidine + spermine ratio remained low in responsive varieties. The addition of spermidine or spermine (2 × 10−3 M) to the culture medium improved significantly the embryo production. Our results suggest that the arginine decarboxylase pathway is involved in PA biosynthesis during the in vitro culture of flower buds. Our study showed that specific ratios of PAs are required for successful gynogenesis in onion.
Improving Biogas Production and Biodegradability of Acid Hydrolytic Cotton Stalk with Addition of Nutritive Salts and Complex Anaerobic Cellulose Decomposing Bacteria

Nutritive salts and complex anaerobic cellulose decomposing bacteria (CACDB) were added for anaerobic digestion process in order to improve biogas production and biodegradability of acid hydrolytic cotton stalk. The results showed that addition of CACDB, nutritive salt I and nutritive salt II could effectively enhance daily biogas production, cumulative biogas and methane yields, in this treatment, the total gas production, daily average gas production, TS gas production rate, VS gas production rate and average yield of methane were all highest and reached 5908.90 mL, 196.96 ± 7.97 mL·d-1, 143.07 ± 5.79 mL·g-1, 156.32 ± 6.33 mL·g-1, 102.58 ± 3.34 mL·d-1, separately. The addition of CACDB and nutritive salts could improve the biodegradability of acid hydrolytic cotton stalk, in all addition treatments, the degradation rates of cellulose and lignin, VS reduction rates were higher and C/N ratios were lower than control treatment. The SEM analysis showed that the microstructure changes of digestion residues were helpful for biogas production.
PERANCANGAN DAN IMPLEMENTASI KERAN AIR OTOMATIS DENGAN SENSOR ULTRASONIK BERBASIS ARDUINO

Along with the development of worldwide era, we already get into the era that full of technology that can help us relieve many works. Many water resources is wasted on unattended water tub because busyness of people on this worldwide era. Actually people can predict the time when water tub is full but it will consume time, energy and would be forgotten because of the busyness. So that in this worldwide era there is a device named Arduino which can be used to create a technology that boost our creativity. Water tap is a tool that was invented with water pipe. This item is not odd to many people. We usually fill our tub with water to bath, wash, cook. To substitute water tap, there is a device named Solenoid Valve. We can use Solenoid Valve to control the flow of water with electricity so that it can close automatic which replace the function of ordinary water tap. With ultrasonic sensor and microcontroller Arduino we can control the Solenoid Valve so that it can work with command. Coding command of mikrocontroler Ardunio can be written with an software named Arduino IDE with is open-source, multiplatform and also easy to use