Miracle-dz/UniFAR-FTUs huggingface dataset:
A general response process theory for situational judgment tests.

Situational judgment tests (SJTs) have emerged as a staple of assessment methodologies for organizational practitioners and researchers. Despite their prevalence, many questions regarding how to interpret respondent choices or how variations in item construction and instruction influence the nature of observed responses remain. Existing conceptual and empirical efforts to explore these questions have largely been rooted in reflexive psychometric measurement models that describe participant responses as indicative of (usually multiple) latent constructs. However, some have suggested that a key to better understanding SJT responses lies in unpacking the judgment and decision-making processes employed by respondents and the psychological and contextual factors that shape how those processes play out. To this end, the present article advances an integrative and generalizable process-oriented theory of SJT responding. The framework, labeled situated reasoning and judgment (SiRJ), proposes that respondents engage in a series of conditional reasoning, similarity, and preference accumulation judgments when deciding how to evaluate and respond to an SJT item. To evaluate the theory's plausibility and utility, the SiRJ framework is translated into a formal computational model and results from a simulation study are analyzed using neural network and Bayesian survival analytic techniques that demonstrate its capability to replicate existing and new empirical effects, suggest insights into SJT interpretation and development, and stimulate new directions for future research. An interactive web application that allows users to explore the computational model developed for SiRJ (https://grandjam.shinyapps.io/sirj) as well as all reported data and the full model/simulation code (https://osf.io/uwdfm/) are also provided. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Are coworkers getting into the act? An examination of emotion regulation in coworker exchanges.

Research on emotional labor-the process through which employees enact emotion regulation (i.e., surface and deep acting) to alter their emotional displays-has predominately focused on service-based exchanges between employees and customers where emotions are commoditized for wage. Yet, recent research has begun to focus on the outcomes of employees engaging in emotion regulation, and surface acting in particular, with coworkers. Given that coworker interactions are qualitatively distinct from those with customers, we build on the emotional labor and emotion regulation literatures to understand why such acts of emotion regulation occur in coworker-based exchanges, and whether there are well-being and social capital costs and/or benefits for doing so. Across 3 complementary studies spanning over 2,500 full-time employees, we adopt a person-centered approach and demonstrate that four distinct profiles of emotion regulation emerge in coworker exchanges: deep actors, nonactors, low actors, and regulators. Further, our results suggest that certain employees are driven to regulate their emotions with coworkers for prosocial reasons (deep actors), whereas others are more driven by impression management motives (regulators). Our results also suggest that while nonactors and deep actors similarly incur well-being benefits (i.e., lower emotional exhaustion and felt inauthenticity), deep actors alone experience social capital gains in the form of higher receipt of help from coworkers, as well as increased goal progress and trust in their coworkers. Combined, our research delineates the motives that drive emotion regulation with coworkers and identifies when such regulatory efforts yield social capital gains for employees. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Role of pharmacogenetics in rifampicin pharmacokinetics and the potential effect on TB-rifampicin sensitivity among Ugandan patients.

BACKGROUND Suboptimal anti-TB drugs exposure may cause multidrug-resistant TB. The role of African predominant SLCO1B1 variant alleles on rifampicin pharmacokinetics and the subsequent effect on the occurrence of Mycobacterium tuberculosis-rifampicin sensitivity needs to be defined. We describe the rifampicin population pharmacokinetics profile and investigate the relevance of SLCO1B1 genotypes to rifampicin pharmacokinetics and rifampicin-TB sensitivity status. METHODS Fifty patients with TB (n=25 with rifampicin-resistant TB and n=25 with rifampicin-susceptible TB) were genotyped for SLOC1B1 rs4149032 (g.38664C>T), SLOC1B1*1B (c.388A>G) and SLOC1B1*5 (c.521 T>C). Steady state plasma rifampicin levels were determined among patients infected with rifampicin-sensitive TB. Data were analysed using NONMEM to estimate population rifampicin pharmacokinetics as well as the effect of SLOC1B1 genotypes on rifampicin pharmacokinetics and on rifampicin-TB sensitivity status. RESULTS Overall allele frequencies of SLOC1B1 rs4149032, *1B and *5 were 0.66, 0.90 and 0.01, respectively. Median (IQR) Cmax and Tmax were 10.2 (8.1-12.5) mg/L and 1.7 (1.125-2.218) h, respectively. Twenty-four percent of patients exhibited Cmax below the recommended 8-24 mg/L range. SLOC1B1 genotypes, gender and age did not influence rifampicin pharmacokinetics or TB-rifampicin sensitivity. CONCLUSIONS Although SLOC1B1 genotype, age and gender do not influence either rifampicin pharmacokinetics or rifampicin-TB sensitivity status, one in every four Ugandan TB patients achieve subtherapeutic plasma rifampicin concentrations.
Update on Collagens: What You Need to Know and Consider

The prevalence of chronic wounds remains a concern for wound care providers. Additional therapies that promote wound healing continue to be on the forefront of wound care. Selecting treatment modalities should be based on current evidence and a critical analysis of that evidence. However, evidence in wound care in the form of randomized controlled trials is lacking. This article describes collagen, its use in wound care, and current evidence for review.
Effect of oligoarginine conjugation on the antiwrinkle activity and transdermal delivery of GHK peptide

GHK (Gly‐His‐Lys), a natural peptide found in human skin and plasma, has been widely used in the cosmeceutical and pharmaceutical fields. The hydrophilic GHK and GHK‐Cu are limited in their abilities to penetrate deeply into skin; because of this, various strategies for their skin delivery have been developed. In this investigation, Arg4 was conjugated with GHK to get heptapeptide, GHK‐R4, and then in vitro antiwrinkle activity and transdermal delivery were compared between GHK and GHK‐R4. Notably, Arg4 conjugation accelerated the cellular penetration of GHK both in vitro and in vivo. Furthermore, higher in vitro antiwrinkle activity and collagen biosynthesis was obtained with GHK‐R4 at much lower doses than with control R4‐free GHK. The enhanced activity and delivery of GHK‐R4 might be due to the cell penetrating ability and matrix metalloproteinase (MMP) inhibitory activity of R4 itself.
The impact of carrion decomposition on the fatty acid methyl ester (FAME) profiles of soil microbial communities in southern Canada

ABSTRACT Profiling microbial communities associated with cadaver decomposition may provide useful information concerning post-mortem intervals and aid in the identification of clandestine graves. Four experiments using pig carcasses as human decomposition analogues were performed over the course of 2011 and 2012 in southern Ontario to document changes in soil microbiology following decomposition. Studies were conducted in both spring and summer to determine the effect of environmental variables on the decomposition process and subsequent changes in gravesoil microbiology. Fatty acid methyl ester (FAME) profiling was used to investigate the community level changes in soil throughout the decomposition process. Shifts in FAME profiles coincided with the onset of active decay and persisted through to the dry remains stage. Results also indicated that FAME profiles differed between seasons and years. These studies highlight the need to document natural changes in microbial communities over seasons and years to establish normal soil profiles and patterns to effectively use this analysis as a tool for post-mortem interval estimation or for locating clandestine graves.
Early Outcome of Donors in Living-Donor Liver Transplantation at King Hussein Medical Center

Results: A total of 54 potential candidates for living-donor liver transplantations were evaluated. Of these, 28 underwent successful hepatectomy for donation. Male to female ratio was 21:7. The mean age was 28.89 ± 1.30(range 19- 49) years. A total of 26 potential donors (48%) were excluded at different points of the workup. The mean operative times were 6.07 ± 1.12 (rang = 4-8 hours). The mean intraoperative blood loss were 428.5 ±296.9 (range: 50 to 1500ml), (intraoperative blood transfusion was required for one donor). Conclusion: Donor hepatectomy in living-donor liver transplantation is a safe procedure. Meticulous and comprehensive selection protocols are a prerequisite for a good outcome.
Enhanced Hybridization and Nanopatterning via Heated Liquid-Phase Infiltration into Self-Assembled Block Copolymer Thin Films.

Organic-inorganic hybrids featuring tunable material properties can be readily generated by applying vapor- or liquid-phase infiltration (VPI or LPI) of inorganic materials in organic templates, with resulting properties controlled by type and quantity of infiltrated inorganics. While LPI offers more diverse choices of infiltratable elements, it tends to yield smaller infiltration amount than VPI, but the attempt to address the issue has been rarely reported. Here, we demonstrate facile temperature-enhanced LPI method to control and drastically increase the quantity and kinetics of Pt infiltration into self-assembled polystyrene-block-poly(2-vinylpyridine) (PS-b-P2VP) block copolymer (BCP) thin films. By applying LPI at mildly elevated temperatures (40 - 80 °C), we showcase controllable optical functionality of hybrid BCP films along with conductive three-dimensional (3D) inorganic nanostructures. Structural analysis reveals enhanced metal loading into BCP matrix at higher LPI temperatures, suggesting multiple metal ion infiltration per monomer of P2VP. Combining temperature-enhanced LPI with hierarchical multilayer BCP self-assembly, we generate BCP-metal hybrid optical coatings featuring tunable antireflective properties as well as scalable conductive 3D Pt nanomesh structures. Enhanced material infiltration and control by temperature-enhanced LPI not only enables tunability of organic-inorganic hybrid nanostructure and properties but also expands the application of BCPs for generating uniquely functional inorganic nanostructures.
Which Factors Are Associated With Adolescent Reports of Experiencing Various Forms of Abuse at the Family Level in Post-Conflict Northern Uganda?

Research assessing familial violence against adolescents, using caregiver–adolescent dyads, is limited in post-conflict settings. This study aimed to determine the prevalence and factors associated with adolescent-reported familial abuse in post-conflict northern Uganda. It also assessed the relationship between abuse subtypes and (a) beliefs supporting aggression and (b) adolescent well-being and life satisfaction. A randomly selected community-based sample of 10- to 17-year-old adolescents (54% girls) and their caregivers (N = 427 dyads) in two northern Uganda districts was used. Abuse outcomes were adolescent reported. All measures used standardized tools that have been adapted for research in resource-limited settings. Analyses used multivariable linear regressions in Stata 14/IC. Overall, physical, emotional, and sexual abuse rates were 70% (confidence interval [CI] = [65.7, 74.4]), 72% (CI = [67.4, 76.0]), and 18.0% (CI = [14.0, 21.2]), respectively. Polyvictimization was 61% (CI = [55.4, 64.7]). There were no gender differences regarding adolescent reports of physical and emotional abuse, but adolescent girls were more likely to report sexual abuse and polyvictimization than adolescent boys. All forms of adolescent-reported abuse (except sexual abuse) were associated with caregiver reports of harsh disciplinary practices. In addition, emotional abuse was associated with physical and sexual abuse. Physical abuse was associated with being an orphan and emotional abuse. Sexual abuse was associated with being a girl, older adolescent age, living in a larger household, and emotional abuse. Polyvictimization was positively associated with being an orphan, younger caregiver age, caregiver-reported poor monitoring and supervision, and higher household socioeconomic status, but negatively associated with lower parental role satisfaction. Physical and emotional (but not sexual) abuse and polyvictimization were associated with beliefs supporting aggression among adolescents. All abuse subtypes were associated with lower levels of perceived well-being and life satisfaction among adolescents in this study. Child abuse prevention programs have the potential to improve adolescent–caregiver interaction and interrupt the violence transmission cycle in this setting.
Long-term trajectories of depression symptoms in mothers of children with cancer.

OBJECTIVE To identify trajectories of depression symptoms in mothers of children with cancer from diagnosis/relapse through 5 years and examine maternal factors at diagnosis/relapse predicting membership in these trajectories. METHOD Mothers (n = 327; Mage = 37.6 years, SD = 7.7 years; 85.9% White) reported depression symptoms near the time of their child's diagnosis/relapse and then again at 1-, 3-, and 5-years postdiagnosis/relapse. Mothers also reported perceived stress, coping (primary control, secondary control, and disengagement coping), and spirituality near the time of diagnosis. Latent class growth analysis was used to identify latent trajectories of depression symptoms, and a 3-step multinomial logistic regression tested covariate predictors of membership in the trajectories. RESULTS Three trajectories were identified: "low depression symptoms" (63.3%), "moderate depression symptoms" (31.5%), and "high depression symptoms" (5.2%). Mothers who used more primary and secondary control coping were more likely to be in the low depression symptom trajectory as compared with the moderate (OR = 1.64, p = .024 and OR = 1.38, p = .013, respectively) or high trajectories (OR = 1.99, p = .008 and OR = 1.81, p = .001, respectively). CONCLUSIONS Although mothers of children with cancer generally displayed improved mental health further from diagnosis, mothers with more depression symptoms after diagnosis/relapse displayed substantial stability in depression symptoms over the 5 years. Mothers of children with cancer may benefit from early screening of mental health and coping strategies, as well as interventions to bolster effective coping for those with elevated depression symptoms. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Moderating Effect of Husband’s Controlling Attitudes on the Relation Between Women’s Household Decision-Making Autonomy and Intimate Partner Violence Experience in Nigeria

Existing studies show a consensus on the importance of women’s household decision-making autonomy. However, the studies also show mixed findings of the association between the variable and intimate partner violence (IPV). In this study, moderating effects of husband’s controlling and domineering attitudes on the association between women’s household decision-making autonomy and husband-perpetrated physical, sexual, and emotional violence were investigated. Data used in the study were drawn from an existing database of a 2013 cross-sectional Demographic and Health Survey (DHS) of nationally representative sample (N = 19,360) of Nigerian married women. Participants were interviewed on measures of women’s autonomy, husband’s attitudes, and husband-perpetrated violence. Results revealed that women who exercised high household decision-making autonomy significantly experienced more physical (b = .31, t = 11.78, p < .001), sexual (b = .05, t = 3.59, p < .01), and emotional (b = .17, t = 9.76, p < .001) violence if they reported relationship with husbands who endorsed high controlling and domineering attitudes. The results represent an extension over existing research and have implications on how husband’s attitudes could improve women’s autonomy and reduce their IPV experience in various intervention settings.
Impact of Nasal Irrigation With Iodized Table Salt Solution on Mucociliary Clearance: Proof-of-Concept Randomized Control Trial

Introduction Saline nasal irrigation is a common recommendation shared between the majority of clinical guidelines for sinusitis and rhinitis in adults and children. Studies involving homemade saline have typically involved the use of noniodized salt. However, the literature does not contain any descriptions for the use of iodized table salt in homemade saline solutions. Objectives To study the usefulness of iodized salt in homemade saline and its impact on mucociliary clearance (MCC). Methods Only healthy volunteers were enrolled in this randomized controlled trial. The sinonasal outcome test (SNOT)-22 and rhinoscopy were used to rule out any clinical evidence of sinusitis or rhinitis in the enrolled subjects. The saccharine clearance time (SCT) was used to evaluate MCC at baseline. Each candidate received 2 different nasal wash solutions—one containing iodized salt and the other containing noniodized salt—on different days. Visual analog scale pain scores were recorded while using each type of nasal wash. The SCT was assessed after each wash. Results Thirty-eight healthy candidates (18 men and 20 women) were enrolled in the study. All subjects were in their 30s. The mean baseline SCT was 10.92 minutes. The use of the noniodized salt solution led to a nonsignificant change (P = .139) in mean SCT (9.68 min). In contrast, a significant change (P = .035) was observed in mean SCT after the use of the iodized salt solution (9.06 min). However, the mean postirrigation SCT was not significantly different between solutions (P = .31). No significant differences were observed in pain/discomfort experience between solutions. Conclusion MCC improved with both solutions. Interestingly, the improvement was significant, when the iodized salt nasal irrigation solution was used. This finding contradicts the conventional recommendation against the use of iodized salt in nasal rinse solution. Moreover, this solution was well tolerated. Further studies regarding the long-term safety are recommended.
Metabolically healthy obesity reduces the risk of Alzheimer’s disease in elders: a longitudinal study

A subgroup of overweight/obese individuals, who had favorable metabolic profiles, was termed as metabolically healthy overweight/obese (MHO). Several studies suggested that MHO individuals were not at increased risk of cardiovascular disease and all-course mortality. However, whether MHO is associated with excess risk of Alzheimer’s disease (AD) in elders remains unclear. To explore the risk of AD among MHO phenotype and investigate whether MHO associates with neurodegenerative biomarkers of AD, we assessed body mass index-metabolic status phenotypes of 1199 longitudinal elders from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort using the Adult Treatment Panel-III (ATP- III) criteria. MHO subjects were at a significantly decreased risk for AD (adjusted HR=0.73, 95% CI: 0.54-0.97) compared with metabolically healthy normal weight (MHNW) subjects. In multivariable linear regression models, the cross-sectional associations of MHO with cerebrospinal fluid (CSF) biomarkers, brain Aβ load, and cortical structure were explored. MHO was positively correlated with CSF-Aβ (β=0.746, P=0.015), hippocampal volume (β=0.181, P=0.011), and whole brain volume (β=0.133, P=0.004). The MHO phenotype of the elder conferred a decreased risk of AD and its role may be driven by Aβ.
Clinical importance of long non-coding RNA LINC00460 expression in EGFR-mutant lung adenocarcinoma

Long non-coding RNAs (lncRNAs) have been reported to be involved in the physiological and pathological processes of tumor pathogenesis, including epithelial-mesenchymal transition (EMT). However, epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) resistance is a major challenge in the treatment of advanced and recurrent EGFR-mutant lung adenocarcinoma. An increased understanding of the underlying mechanisms would aid in the development of effective therapeutic strategies against EGFR-TKI resistance, strategies which are urgently required for clinical therapy. In this study, long non-coding RNA LINC00460 was identified as a novel marker of a poor response to EGFR-TKI and prognosis. In lung cancer cells, LINC00460 promoted EGFR-TKI resistance as a competitive decoy for miR-149-5p, thereby facilitating interleukin (IL)-6 expression and inducing EMT-like phenotypes. The knockdown or knockout of LINC00460 in gefitinib-resistant non-small cell lung cancer cells restored the response to EGFR-TKI. In addition, as compared with patients with a low LINC00460 expression in tumors, those with a high LINC00460 expression had a significantly shorter progression-free survival following gefitinib therapy, and a shorter overall survival. Therefore, LINC00460 may be a predictor of and potential therapeutic target for EGFR-TKI resistance.
Integrin Linked Kinase as a therapeutic target for treating breast cancer : the value of using multiple endpoints to assess therapeutic effects of targeted drugs and drug combinations

ii TABLE OF CONTENTS . iv LIST OF TABLES. vi LIST OF FIGURES . vii ABBREVIATIONS . x ACKNOWLEDGEMENTS . xiii CO-AUTHORSHIP STATEMENT . xiv CHAPTER 1. 1 1.1 Overview . 1 1.2 Hypothesis . 4 1.3 Specific Research Aims . 4 1.4 Breast Cancer . 5 1.4. 1 The Human Breast . 7 1.4. 2 Etiology and Pathogenesis of Breast Cancer . 11 1.4. 3 Histological Types of Breast Cancer . 17 1.4. 4 Prognostic and Predictive Factors: Identification of Molecular Targets . 18 1.4. 5 Current Treatment Options for Patients with Breast Cancer . 23 1.5 Next Generation Therapeutics . 28 1.5. 1 Combination Chemotherapy and Analysis of Drug-Drug Interactions . 29 1.5. 2 Targeting Integrin Linked Kinase as a Means to Treat Breast Cancer . 33 1.5. 3 ILK Structure and Function . 33 1.5. 4 The role of ILK in Normal Tissues . 36 1.5. 5 ILK in Carcinogenesis and Role in Human Cancers . 38 1.5. 6 Targeting ILK for Treatment of Cancer . 40 1.6 Summary . 44 1.7 Significant Outcomes . 46 1.8 References . 48 CHAPTER 2 QLT0267, a small molecule inhibitor targeting Integrin-Linked Kinase (ILK), and Docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model. * . 64 2.
Critique of the concept of flexibility / Critique de la notion de flexibilité

This monograph proposes a theoretical and methodological critique of the concept of flexibility. This critique is based on evaluation criteria of the concepts offered by the social sciences research methodology. Through this exercise, the concept of flexibility appears to be derived from the explanatory functionalist framework of variability and change, which is not able to interpret the firm and work transformations as the current literature is emphasizing.