Miracle-dz/UniFAR-FTUs huggingface dataset:
Buckling and Post-Buckling Behavior of Perfect/Perforated Composite Cylindrical Shells under Hydrostatic Pressure

In this paper, the buckling and post-buckling behavior of perfect and perforated composite cylindrical shells subjected to external hydrostatic pressure was experimentally investigated. Three filament wound composite cylindrical shells were fabricated from T700-12K Carbon fiber/Epoxy, two of which were perforated and reinforced. A test platform was established that allows researchers to observe the deformation of composite cylindrical shells under hydrostatic pressure in real-time during test. According to experimental observation, strain response and buckling deformation wave were discussed. Comparative analysis was carried out based on the experimental observation and finite element prediction. Results show that the deformation of composite cylindrical shell under hydrostatic pressure included linear compression, buckling and post-buckling processes. The buckling behavior was a progressive evolution process which accounted for 20% of the load history, and strain reversal phenomenon generally occurred at the trough of the buckling wave. As for the postbuckling deformation, the load carrying capacity of the shell gradually decreased while the magnitude of strain continued increasing. Both the perfect and perforated composite cylindrical shells collapsed at the trough of the buckling wave. Comparing with the perfect shell, it was validated the reinforcement design could effectively ensure the load carrying capacity of the perforated composite cylindrical shell.
GRID-SCALE EXPLORATION OF THE RELATIONSHIP BETWEEN ECOLOGICAL HEALTH AND HUMAN PRESSURE IN THE THREE GORGES RESERVOIR REGION

Human activity is becoming the key factor influencing ecological health changes and clarifying the nature of that influence could effectively promote regional ecological restoration. Commonly used human-related factors (e.g., social and economic census data) can only be constrained at the administrative division, and they lead to a loss of detailed spatial characteristics. In this study, we applied human activity intensity (HAI), mapped at the grid scale, to represent pressures of human activity on the ecosystem. Taking the Three Gorges Reservoir Region (TGRR) as the study area, the spatial heterogeneity of the influences of human pressure on ecological health was analyzed. The results showed that, in the TGRR from 2000 to 2018, there was an overall improvement of ecological health and a significant spatial reorganization of HAI. The impact of HAI on ecological health had significant spatial heterogeneity. In areas where HAI had decreased, ecological health was prone to improve significantly. In contrast, in areas where HAI had increased, ecological health tended to become worse, and only when the increase of HAI exceeded 0.08 would that tendency be significant. Compared to urban areas, HAI change had even broader impacts on ecological health in remote mountain areas, where a more remarkable restoration of the ecosystem was experienced.
Microbiome perturbations during domestication of the green June beetle (Cotinis nitida)

Animal-associated microbiomes are critical to the well-being and proper functioning of the animal host, but only limited studies have examined in-sect microbiomes across different developmental stages. These studies revealed large shifts in microbiome communities, often because of significant shifts in diet during insects’ life cycle. Establishing insect colonies as model laboratory organisms and understanding how to properly feed and care for animals with complex and dynamic life cycles requires improved data. This study examined laboratory raised green June beetles (Cotinis nitida) captured from the field upon emergence from pupae. Starting with wild-caught adults, two generations of beetles were reared in the laboratory, ending with an entirely laboratory raised generation of larvae. The study compared the microbiomes of each generation and the microbiomes of larvae to adults. This study suggests that a diet of commercial, washed fruit for adults and commercial, packaged, organic alfalfa meal for larvae resulted in depauperate gut microbiome communities. Fermentative yeasts were completely absent in the laboratory-raised adults, and major bacterial population shifts occurred from one generation to the next, coupled with high morbidity and mortality in the laboratory-raised generation. Providing laboratory-raised beetles fresh-collected fruit and the larvae field-harvested detritus may therefore vastly improve their health and survival.
Comparing the Ratio of Therapist Support to Internet Sessions in a Blended Therapy Delivered to Trauma-Exposed Veterans: Quasi-experimental Comparison Study

Background Blended models of therapy, which incorporate elements of both internet and face-to-face methods, have been shown to be effective, but therapists and patients have expressed concerns that fewer face-to-face therapy sessions than self-guided internet sessions may be associated with lower therapeutic alliance, lower program completion rates, and poorer outcomes. Objective A multisite quasi-experimental comparison study with a noninferiority design implemented in routine clinical care was used to assess webSTAIR, a 10-module blended therapy derived from STAIR (skills training in affective and interpersonal regulation) for trauma-exposed individuals delivered with 10 weekly therapist sessions (termed Coach10) compared to 5 biweekly sessions (Coach5). It was hypothesized that Coach5 would be as good as Coach10 in a range of outcomes. Methods A total of 202 veterans were enrolled in the study with 101 assigned to Coach5 and 101 to Coach10. Posttraumatic stress disorder (PTSD) symptoms, depression, emotion regulation, interpersonal problems, and social functioning measures were collected pre-, mid-, and posttreatment, and at a 3-month follow-up. Noninferiority analyses were conducted on symptom outcome measures. Comparisons were made of continuous and categorical measures regarding participant and therapist activities. Results Participants reported moderate to severe levels of baseline PTSD, depression, or both. Significant reductions were obtained in all symptom measures posttreatment and at the 3-month follow up. Coach5 was not inferior to Coach10 in any outcome. Therapeutic alliance was at an equivalently high level across the 2 treatment conditions; completion rates and web usage were similar. Total session time was substantially less for the Coach5 therapists than the Coach10 therapists. Both programs were associated with a low, but equal number of therapist activities related to scheduling and crisis or motivational sessions. Conclusions A blended model delivered with 5 sessions of therapist support was noninferior to 10 sessions in individuals with moderate to severe symptoms. Future studies identifying patient characteristics as moderators of outcomes with high versus low doses of therapist support will help create flexible, technology-based intervention programming.
WORK STUDY CONFLICT AGAINST BURNOUT: THE MODERATION ROLE OF SOCIAL SUPPORT FROM FRIENDS

The conflict between work and family roles has been widely studied. However, recently, research has progressed to study roles outside of work and family. For example, several researchers have investigated the conflict between work and educational roles. However, this study focuses on the occurrence of burnout. Thus this study seeks to contribute to the literature on work-education conflict in two main ways. First, we investigate the relationship between work study conflicts and the occurrence of burnout. Furthermore, to prove the role of social support from friends as a moderating variable. Participants in this study were 81 students. The results of this study support our proposed hypothesis.
Genotyping by sequencing reveals genetic relatedness and duplicates amongst local cassava (Manihot esculenta Crantz) landraces and improved genotypes in Kenya

Background: Future demand for cassava is expected to increase to mitigate climatic changes, sustain food security and provide raw materials for industry. To meet these demands, adoption of modern omics methods ensures reliability, precision and timely delivery of more productive and resilient varieties. Therefore the purpose of this study was to contribute towards accurate identification of cassava accessions from a mix of duplicate clones, diverse local landraces (LARs) and improved genotypes (IMGs) in farmer fields. This is vital for cassava breeding. Results: A total of 112 germplasms sampled through a field survey in major cassava growing regions of Kenya, were genotyped using single nucleotide polymorphisms (SNPs) markers generated through genotyping-by-sequencing (GBS) approach. Of the 33672 SNPs, 88% were anchored onto chromosomes, 3% in scaffolds and 9% could not be mapped. LD pruning and identity by state matrix estimation revealed 5808 SNPs that were used for hierarchical clustering and ADMIXTURE analysis for ancestries. Considering a sub-population of 2 - 20, a 5-fold cross-validation procedure identified 14 subpopulations present in the population from which the population structure was modeled. Approximately 48% of the germplasms were classified into 17 independent clusters as identical clones or duplicates. The remaining 52% formed admixtures and hence unique or non-duplicated clones; reducing the total number of samples surveyed from 112 to 73. Of the duplicates, 10 clusters were formed from LARs, four from IMGs, and three from a mix of both LARs and IMGs. The major and minor clusters contained 8 and 2 accessions, respectively. About 71% of clusters contained accessions from the same geographical region while 29% had accessions from different regions. The results revealed genetic relationships amongst LARs and IMGs. Duplication of LARs was attributed to historical sharing or exchange of planting materials by farmers while duplicates of IMGs could be attributed to convergent evolution, selection, or sharing of common parentage. The high number of admixtures or unique clones implied minimal loss of genetic diversity. Geographical restriction of clusters adduced to the minimal movement of planting materials across the country, perhaps linked to either inefficient seed distribution system or disease-driven quarantine measures. Conclusions: GBS was successfully used to study the genetic relatedness of cassava genetic resources and variety identification in farmer fields. This omics approach and data herein generated could be adopted by breeders and other stakeholders in designing efficient and effective cassava improvement programs which might include the development of a core set of diagnostic markers for quality assurance, disease resistance, and targeted genomic profiling in cassava.
Attenuation properties of common 3D printed FFF plastics for mammographic applications

The aim of this study was to evaluate the feasibility of using acrylonitrile butadiene styrene (ABS) and polylactic acid (PLA) 3D printing filaments as materials for mammography phantom construction, comparing their attenuation properties at two different set-ups: at a Calibration Laboratory and directly to a mammography unit. The attenuation of 3D printed test phantoms of two types of common 3D printing Fused Filament Fabrication (FFF) filaments (ABS and PLA) were characterized in comparison with polymethylmethacrylate (PMMA). The measurements were carried out with standard IEC 61267 X-rays, using RQR 2-M and RQR 4-M beam qualities at the Instruments Calibration Laboratory, and then applied to a mammography unit, with measurements with 28 kVp and 35 kVp. Attenuation characteristics evaluated indicates the suitable equivalence of PLA to PMMA for 3D printing breast tissue equivalent complex phantoms. The plastic materials used in this study suggest that the FFF technique may be suitable for mammography phantom development.
Blind-Watermarking—Proof-of-Concept of a Novel Approach to Ensure Batch Traceability for 3D Printed Tablets

Falsified medicines are a major issue and a threat around the world. Various approaches are currently being investigated to mitigate the threat. In this study, a concept is tested that encodes binary digits (bits) on the surface of Fused Deposition Modelling (FDM) 3D printed geometries. All that is needed is a computer, a FDM 3D printer and a paper scanner for detection. For the experiments, eleven different formulations were tested, covering the most used polymers for 3D printing in pharma: Ethylene-vinyl acetate (EVA), polyvinyl alcohol (PVA), polylactic acid (PLA), Hypromellose (HPMC), ethyl cellulose (EC), basic butylated-methacrylate-copolymer (EPO), and ammonio-methacrylate-copolymer type A (ERL). In addition, the scanning process and printing process were evaluated. It was possible to print up to 32 bits per side on oblong shaped tablets corresponding to the dimensions of market preparations of oblong tablets and capsules. Not all polymers or polymer blends were suitable for this method. Only PVA, PLA, EC, EC+HPMC, and EPO allowed the detection of bits with the scanner. EVA and ERL had too much surface roughness, too low viscosity, and cooled down too slowly preventing the detection of bits. It was observed that the addition of a colorant or active pharmaceutical ingredient (API) could facilitate the detection process. Thus, the process could be transferred for 3D printed pharmaceuticals, but further improvement is necessary to increase robustness and allow use for more materials.
Fixed Abrasive Polishing in an Anhydrous Environment: A Material Removal Model for Fused Silica

Due to the prevalent randomness and uncertainties associated with traditional loose polishing, fixed abrasive polishing in an anhydrous environment has been chosen as a new polishing method. In this paper, cerium oxide is the main component for polishing pellets, and the particle size distribution of cerium oxide is measured. A material removal model for fixed abrasive polishing of fused silica in an anhydrous environment is proposed. Based on this model, we simulate the roughness of fused silica in fixed abrasive polishing process by using a Monte Carlo method with a constant removal mechanism and obtain the percentage of plastic and chemical removal. The percentage result is then taken into the material removal equation to calculate the material removal rate. The final convergence value of the roughness with 2 μm particle size is about 1.8 nm, while the final convergence value of the surface roughness of the workpiece by Monte Carlo simulation is about 1 nm. The experimental material removal rate at 2 μm particle size is 5.48 μm/h, while the simulation result is 4.29 μm/h. The experiment data of roughness and material removal rate all verify the model.
The Gram-Negative Bacilli Isolated from Caves—Sphingomonas paucimobilis and Hafnia alvei and a Review of Their Involvement in Human Infections

The opportunistic infections with Gram-negative bacilli are frequently reported. The clinical studies are focused on the course of human infectious and very often the source of infection remain unclear. We aim to see if the Gram-negative bacilli isolated from a non-contaminated environment—the caves—are reported in human infections. Eleven samples were collected from six Romanian caves. We used the standard procedure used in our clinical laboratory for bacterial identification and for antibiotic susceptibility testing of the cave isolates. Out of the 14 bacterial strains, three isolates are Gram-negative bacilli—one isolate belong to Hafnia alvei and two strains belong to Sphingomonas paucimobilis. We screened for the published studies—full-text original articles or review articles—that reported human infections with S. paucimobilis and H. alvei. Data sources—PubMed and Cochrane library. We retrieved 447 cases from 49 references—262 cases (58.61%) are S. paucimobilis infections and 185 cases (41.39%) are H. alvei infections. The types of infections are diverse but there are some infections more frequent; there are 116 cases (44.27%) and many infections of the bloodstream with S. paucimobilius (116 cases) and 121 cases (65.41%) are urinary tract infections with H. alvei. The acquired source of the bloodstream infections is reported for 93 of S. paucimobilis bloodstream infections—50 cases (43%) are hospital-acquired, and 40 cases (37%) are community-acquired. Most of the infections are reported in patients with different underlying conditions. There are 80 cases (17.9%) are reported of previously healthy persons. Out of the 72 cases of pediatric infections, 62 cases (86.11%) are caused by S. paucimobilis. There are ten death casualties—three are H. alvei infections, and seven are S. paucimobilis infections.
Antimicrobial Susceptibility, Virulence, and Genomic Features of a Hypervirulent Serotype K2, ST65 Klebsiella pneumoniae Causing Meningitis in Italy

The rise of a new hypervirulent variant of Klebsiella pneumoniae (hvKp) was recently reported, mainly linked to the ST23 lineage. The hvKp variants can cause severe infections, including hepatic abscesses, bacteremia, and meningitis, with a particularly disconcerting propensity to cause community-acquired, life-threatening infection among young and otherwise healthy individuals. The present study aimed to report the clinical characteristics of a hypermucoviscous K. pneumoniae strain isolated in Italy and sustaining recurrent meningitis in a patient of Peruvian origin. A further objective was to retrospectively investigate, by means of whole-genome sequencing (WGS) analysis, the genomic features of such an isolate. The hypermucoviscosity phenotype of the strain (sk205y205t) was determined using the string test. Genomic information was obtained by WGS (Illumina) and bioinformatic analysis. Strain sk205y205t was susceptible to most antibiotics, despite the presence of some resistance genes, including blaSHV-11, blaSHV-67, fosA, and acrR. The isolate belonged to ST65 and serotype K2, and exhibited several virulence factors related to the hvKp variant. Among these, were the siderophore genes entB, irp2, iroN, iroB, and iucA; the capsule-regulating genes rmpA and rmpA2; and the type 1 and 3 fimbriae fimH27 and mrkD, respectively. A further operon, encoding the genotoxin colibactin (clbA-Q), was also identified. The virulence plasmids pK2044, pRJA166b, and pNDM. MAR were also detected. Phylogenetic investigation showed that this Italian strain is highly similar to a Chinese isolate, suggesting a hidden circulation of this hvKp ST65 K2 lineage.
BnERF114.A1, a Rapeseed Gene Encoding APETALA2/ETHYLENE RESPONSE FACTOR, Regulates Plant Architecture through Auxin Accumulation in the Apex in Arabidopsis

Plant architecture is crucial for rapeseed breeding. Here, we demonstrate the involvement of BnERF114.A1, a transcription factor for ETHYLENE RESPONSE FACTOR (ERF), in the regulation of plant architecture in Brassica napus. BnERF114.A1 is a member of the ERF family group X-a, encoding a putative 252-amino acid (aa) protein, which harbours the AP2/ERF domain and the conserved CMX-1 motif. BnERF114.A1 is localised to the nucleus and presents transcriptional activity, with the functional region located at 142–252 aa of the C-terminus. GUS staining revealed high BnERF114.A1 expression in leaf primordia, shoot apical meristem, leaf marginal meristem, and reproductive organs. Ectopic BnERF114.A1 expression in Arabidopsis reduced plant height, increased branch and silique number per plant, and improved seed yield per plant. Furthermore, in Arabidopsis, BnERF114.A1 overexpression inhibited indole-3-acetic acid (IAA) efflux, thus promoting auxin accumulation in the apex and arresting apical dominance. Therefore, BnERF114.A1 probably plays an important role in auxin-dependent plant architecture regulation.
VTON-SCFA: A Virtual Try-On Network Based on the Semantic Constraints and Flow Alignment

An image-based virtual try-on system transfers an in-shop garment to the corresponding garment region of a reference person, which has huge application potential and commercial value in online clothing shopping. Existing methods have difficulty preserving garment texture and body details because of rough garment alignment and imperfect detail-retention strategies. To address this problem, we propose a virtual try-on network based on semantic constraints and flow alignment. The key idea of the framework is as follows: 1) a global-local semantic predictor (GLSP) is proposed to generate a reasonable target semantic map, which clearly guides the correct alignment of the in-shop garment with the body and the generation of try-on result; and 2) a novel appearance flow-based garment alignment network (AFGAN) is proposed to align the in-shop garment with the body, which is important to preserve maximum garment detail and ensure natural and realistic warping; and 3) we propose a synthesis strategy to integrate the aligned garment and the human body to preserve maximum body detail for generating a realistic result and preventing cross-occlusion and pixel confusion between different body parts. Experiments on the existing benchmark dataset demonstrate that the proposed method achieves the best performance on qualitative and quantitative experiments among the state-of-the-art virtual try-on techniques.
Delayed two-stage nipple sparing mastectomy and simultaneous expander-to-implant reconstruction of the large and ptotic breast.

Background Large and ptotic breasts are considered an anatomical contraindication for nipple sparing mastectomy (NSM). Necrosis rates can be as high as 76%. The authors examined whether targeted preshaping mastopexy/reduction combined with simultaneous two-stage preshaping of the implant pocket prepares for an uneventful implant reconstruction. Methods Macromastia and ptosis patients opting for risk-reducing NSM or having a peripherally localized carcinoma in situ, were offered a two-stage mastopexy/reduction simultaneously with preshaping of the implant pocket by subpectoral expansion. Only the inferior pedicle bearing the nipple-areola complex (NAC), remained. A delayed secondary NSM and tissue expander-to-implant reconstruction was scheduled 3 months later. The use of an acellular dermal matrix (ADM) was not necessary because the capsule around the expander created a hammock supporting the definite prosthesis. Follow up was at 2 weeks, 3 months, and 6 months. Results Forty-one procedures were performed in 24 patients. The mean age was 45±12.08 years (range, 22 to 72 years). Patients' mean body mass index (BMI) was 26.79 kg/m2 (range, 19 to 35 kg/m2). One patient had diabetes and two smoked. One transient epidermolysis of the NAC occurred in each stage. No NAC or skin necrosis occurred; no implant had to be removed. Conclusions A two-stage mastopexy/reduction, simultaneously with preshaping of the implant pocket by tissue expansion and followed by a 3-month delayed secondary NSM with tissue expander-to-implant reconstruction is a safe technique in large ptotic breasts.
Evaluate theCorrelationbetweentheTIMIFrameCount, IMR,and CFR in Coronary Microvascular Disease

Department of Cardiology and Institute of Vascular Medicine, Peking University ird Hospital, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China Department of Cardiovascular Disease, Peking University ird Hospital, Yan’an Branch, Yan’an, China