Miracle-dz/UniFAR-FTUs huggingface dataset:
Carbon Reduction Strategies Based on an NW Small-World Network with a Progressive Carbon Tax

There is an increasingly urgent need to reduce carbon emissions. Devising effective carbon tax policies has become an important research topic. It is necessary to explore carbon reduction strategies based on the design of carbon tax elements. In this study, we explore the effect of a progressive carbon tax policy on carbon emission reductions using the logical deduction method. We apply experience-weighted attraction learning theory to construct an evolutionary game model for enterprises with different levels of energy consumption in an NW small-world network, and study their strategy choices when faced with a progressive carbon tax policy. The findings suggest that enterprises that adopt other energy consumption strategies gradually transform to a low energy consumption strategy, and that this trend eventually spreads to the entire system. With other conditions unchanged, the rate at which enterprises change to a low energy consumption strategy becomes faster as the discount coefficient, the network externality, and the expected adjustment factor increase. Conversely, the rate of change slows as the cost of converting to a low energy consumption strategy increases.
Review expert collaborative recommendation algorithm based on topic relationship

The project review information plays an important role in the recommendation of review experts. In this paper, we aim to determine review expert's rating by using the historical rating records and the final decision results on the previous projects, and by means of some rules, we construct a rating matrix for projects and experts. For the data sparseness problem of the rating matrix and the "cold start" problem of new expert recommendation, we assume that those projects/experts with similar topics have similar feature vectors and propose a review expert collaborative recommendation algorithm based on topic relationship. Firstly, we obtain topics of projects/experts based on latent Dirichlet allocation (LDA) model, and build the topic relationship network of projects/experts. Then, through the topic relationship between projects/experts, we find a neighbor collection which shares the largest similarity with target project/expert, and integrate the collection into the collaborative filtering recommendation algorithm based on matrix factorization. Finally, by learning the rating matrix to get feature vectors of the projects and experts, we can predict the ratings that a target project will give candidate review experts, and thus achieve the review expert recommendation. Experiments on real data set show that the proposed method could predict the review expert rating more effectively, and improve the recommendation effect of review experts.
An Improved Hybrid Canopy-Fuzzy C-Means Clustering Algorithm Based on MapReduce Model

The fuzzy c-means (FCM) is a frequently utilized algorithm at present. Yet, the clustering quality and convergence rate of FCM are determined by the initial cluster centers, and so an improved FCM algorithm based on canopy cluster concept to quickly analyze the dataset has been proposed. Taking advantage of the canopy algorithm for its rapid acquisition of cluster centers, this algorithm regards the cluster results of canopy as the input. In this way, the convergence rate of the FCM algorithm is accelerated. Meanwhile, the MapReduce scheme of the proposed FCM algorithm is designed in a cloud environment. Experimental results demonstrate the hybrid canopy-FCM clustering algorithm processed by MapReduce be endowed with better clustering quality and higher operation speed.
The Molecular Basis of Leukocyte Adhesion Involving Phosphatidic Acid and Phospholipase D*

Background: Leukocytes adhere to solid surfaces, such as capillary beds, during inflammation. Results: A new molecular mechanism with PLD-derived PA that acts on Arp explains cell adhesion. Conclusion: PLD and PA are key players in a reciprocal activation of actin dynamics. Significance: A prolonged process counteracts the reversible, beneficial nature of adhesion, leading to chronic inflammation. Defining how leukocytes adhere to solid surfaces, such as capillary beds, and the subsequent migration through the extracellular matrix, is a central biological issue. We show here that phospholipase D (PLD) and its enzymatic reaction product, phosphatidic acid (PA), regulate cell adhesion of immune cells (macrophages and neutrophils) to collagen and have defined the underlying molecular mechanism in a spatio-temporal manner that coincides with PLD activity timing. A rapid (t½ = 4 min) and transient activation of the PLD1 isoform occurs upon adhesion, and a slower (t½ = 7.5 min) but prolonged (>30 min) activation occurs for PLD2. Importantly, PA directly binds to actin-related protein 3 (Arp3) at EC50 = 22 nm, whereas control phosphatidylcholine did not bind. PA-activated Arp3 hastens actin nucleation with a kinetics of t½ = 3 min at 300 nm (compared with controls of no PA, t½ = 5 min). Thus, PLD and PA are intrinsic components of cell adhesion, which reinforce each other in a positive feedback loop and react from cues from their respective solid substrates. In nascent adhesion, PLD1 is key, whereas a sustained adhesion in mature or established focal points is dependent upon PLD2, PA, and Arp3. A prolonged adhesion could effectively counteract the reversible intrinsic nature of this cellular process and constitute a key player in chronic inflammation.
Crossing boundaries: improving communication in cerebral palsy care

In the Netherlands, children with cerebral palsy are the largest diagnostic group treated in paediatric rehabilitation, requiring specialized health-, education- and social services of multiple professionals from diverse organizations. To provide ‘integrated care’ in these settings, effective care coordination is essential, though in practice this is challenged by inadequate communication across the child’s care network. In order to improve communication across the integrated care setting of cerebral palsy, the present study aimed to (i) identify experienced gaps in parent-professional and inter-professional communication in three Dutch cerebral palsy care regions; and (ii) obtain insight in the feasibility and usability of an ‘eHealth’-application as a potential improvement strategy for the identified gaps in communication in each care region. To identify experienced gaps in communication a mixed method approach attuned to integrated care settings was developed and applied in each care region. Parents primarily experienced gaps in inter-professional communication, ranging from lack of cooperation and patient-centeredness to insufficient information-exchange and consistency of information. Consequently, parents had to take up the role of messenger of information and/ or care coordinator. Involved professionals recognized these gaps and primarily attributed them to capacity problems, lack of interdisciplinary guidelines and a clear definition of roles, tasks and responsibilities. Based on these gaps an asynchronous secure web-based system for parent-professional and inter-professional communication was developed, aimed to increase patient centeredness, facilitate inter-professional contact and enhance network transparency. A 6-month pilot evaluation in each care region showed broad variation in frequency of system use and its experienced added value, which was related to users’ actual consultation needs and the complexity of the child’s care network. The system’s technical feasibility and added value, although more pronounced for parents than professionals, merit further research into its effective implementation for those patients who require frequent consultation across various organizations and settings. In addition, further development of the technology should focus on incorporating advanced consultation options, next to increasing the system’s ease of use and its integration into daily care practice. This requires an interactive process of co-creation with relevant stakeholders, in order to realize a ‘fit-for-all’ service tailored to specific user needs.
Candida quercitrusa Candidemia in a 6-Year-Old Child

ABSTRACT We present the first case of candidemia due to Candida quercitrusa in a pediatric patient. The identification of the isolate was protracted and ultimately dependent upon sequence analysis of the internal transcribed spacer region. To further define the antifungal susceptibility characteristics of this species, we performed antifungal susceptibility testing of clinical and type strains. In light of the antifungal susceptibility testing results, we caution against the use of fluconazole for treating C. quercitrusa infections.
AODV-MR: AODV with multi-RREP for VANET

VANETs are a promising situation to improve the road traffic safety, traffic monitoring and other applications. However, the vehicles mobility and versatile topology lead to frequent failure of VANET links. In this paper, we propose a new scalable routing scheme named AODV-MR (AODV with multi-RREP). A novel metric is used to detect the link connectivity, which is calculated in every node by broadcasting HELLO messages during the route discovery, source vehicle receiving multi-RREPs will determine the optimal route and suboptimal route by considering the factors of minimal hops and route cost metric (RCM). Moreover, the AODV-MR plays a key role in repairing broken routes and the carry-and-forward mechanism was utilized to repair route. Simulation results show that the performance of new scheme is superior to AODV in terms of high packet delivery radio, links reliability and end to end delay.
Lattice Codes and Generalized Minimum-Distance Decoding for OFDM Systems

Lattice coding of orthogonal frequency-division multiplexing (OFDM) systems is considered. Mapping of multilevel construction lattices to OFDM blocks is shown, and a methodology for probabilistic analysis of multistage generalized minimum distance (GMD) decoding of the received OFDM blocks is shown. As a case study, transmission of points from a 128-dimensional Barnes-Wall lattice is considered. Tight approximations to the system-error rate are obtained and verified by simulation. It appears that GMD decoding of lattice-encoded OFDM provides high coding gain at low complexity
Gender Differences in Body Composition from Childhood to Old Age: An Evolutionary Point of View

Abstract In this cross-sectional study gender differences in body composition (relative fat mass and lean body mass adjusted by height) were analyzed among 869 girls and 780 boys aging between 6 and 18 years and 513 adult women and 412 adult men aging between 19 and 92 years. Body composition was determined by BIA method among children and adolescents and dual energy x-ray absorptiometry (DEXA) among adults. It could be shown that males and females differed significantly in body composition throughout life. Even during prepuberty, girls exhibited a significantly higher amount of body fat and a significantly lower amount of lean body mass than their male counterparts. These gender differences are found throughout life. The observed results are interpreted in a proximate and an ultimate sense. Furthermore the impact of modern life style in industrialized countries is discussed.
Survivin in esophageal cancer: An accurate prognostic marker for squamous cell carcinoma but not adenocarcinoma

We quantified the expression of survivin, both as mRNA in real‐time PCR and protein in immunohistochemistry, in tumor samples of 112 patients with esophageal cancer (56 squamous cell carcinomas and 56 adenocarcinomas). Overall survival of squamous cell carcinoma patients with high survivin mRNA levels was significantly less than that of patients with low survivin mRNA levels (p = 0.0033). Distribution pattern of survivin (nuclear vs. cytoplasmic or mixed) was not correlated to survival, while the extent of immunostaining was significantly correlated to survivin mRNA values (p = 0.016) and had prognostic relevance in univariate analysis (p = 0.0012). Cox's proportional‐hazard regression model showed that tumor survivin expression in esophageal squamous cell carcinoma was the most important prognostic factor, independent of tumor stage and other histopathological factors, both as mRNA relative value (p = 0.0259) and protein immunostaining (p = 0.0147). In esophageal adenocarcinoma, survivin expression and pattern of distribution had no prognostic relevance. Thus, quantifying survivin expression provides a prognostic marker only for esophageal squamous tumors. © 2006 Wiley‐Liss, Inc.
Career Entry and Success after Tertiary Vocational Education

Using the Swiss Graduate Survey, we study how the type of tertiary education an individual chooses (i.e., vocational or academic) influences career entry and labor market success after graduation. Our results show that vocational graduates face less risky career entry than academic graduates. Considering endogenous educational choice by using parental education as an instrument, we find higher returns for vocational tertiary education. In the longer term, initial educational type effects disappear, so vocational and academic graduates face the same risk and return. Therefore, career entry for vocational graduates compares favorably to that of academic graduates, while career success for both educational types equalizes over time.
A Compact Circularly Polarized Slotted Patch Antenna for GNSS Applications

A compact circularly polarized (CP) square-ring slotted patch antenna with vias is proposed for global navigation satellite systems (GNSS). Four square-ring-shaped slots are cut symmetrically onto a square patch radiator along its diagonals for wide-angle CP radiation and miniaturization. The antenna size is further reduced by grounding the central patches surrounded by the square-ring-shaped slots. An antenna prototype with an overall size of 60 mm × 60 mm × 5 mm shows a measured 10-dB return loss bandwidth of 90.0 MHz (1.565-1.655 GHz) with a maximum gain of 4.65 dBic. The measured 3-dB axial ratio (AR) bandwidth is 35.0 MHz (1.57-1.605 GHz) with a 3-dB AR beamwidth of more than 140 ° across the bandwidth.
Assessment of Heart Rates and Blood Pressure in Different Salat Positions

Purpose This study reports the effects of the Muslim prayer, known as Salat, on heart rate (HR) and blood pressure (BP) while performing and miming the actions of Salat: standing, bowing, prostrating and sitting. Subjects Thirty Muslim subjects were asked to perform the actual and mime Salat. Methods HR and BP were measured using a Schiller AT-102 Electrocardiograph and an Omron SEM-1 Automatic Blood Pressure Monitor. Results The findings revealed that there was a significant difference in the HR of the subjects between performing and miming Salat. The standing and prostration positions of Salat produced the highest and the lowest HR, respectively. A lower HR may be of potential benefit to an individual's health. The systolic and the diastolic BP decreased significantly after performance and mime of Salat, and a greater reduction in BP was observed during performance of Salat. Conclusion This is the first study of HR and BP in relation to Salat positions. The findings will encourage further studies to explore the benefits of Salat maneuvers for patients with cardiovascular diseases.
VRK 1 Signaling Pathway in the Context of the Proliferation Phenotype in Head and Neck Squamous Cell Carcinoma

The vaccinia-related kinase (VRK) proteins are a new family with three members in the human kinome. The VRK1 protein phosphorylates several transcription factors and has been postulated to be involved in regulation of cell proliferation. In normal squamous epithelium, VRK1 is expressed in the proliferation area. Because VRK1 can stabilize p53, the expression of the VRK1 protein was analyzed in the context of the p53 pathway and the proliferation phenotype in a series of 73 head and neck squamous cell carcinomas. VRK1 protein level positively correlated with p53 response proteins, particularly hdm2 and p21. The VRK1 protein also correlated positively with several proteins associated with proliferation, such as cyclin-dependent kinase 2 (CDK2), CDK6, cdc2, cyclins B1 and A, topoisomerase II, survivin, and Ki67. The level of VRK1 protein behaves like a proliferation marker in this series of head and neck squamous cell carcinomas. To identify a possible regulatory role for VRK1 and because it regulates gene transcription, the promoters of two genes were studied, CDK2 and SURVIVIN , whose proteins correlated positively with VRK1. VRK1 increases the activity of both the CDK2 and SURVIVIN gene promoters. The expression of VRK1 was analyzed in the context of regulators of the G1-S transition. VRK1 protein levels increase in response to E2F1 and are reduced by retinoblastoma and p16. These data suggest that VRK1 might play a role in cell cycle regulation and is likely to represent the beginning of a new control mechanism of cell cycle, particularly late in the G1-S phase. (Mol Cancer Res 2006;4(3):177–85)
Backsheet metallization of IBC silicon solar cells

A simplified interconnection/metallization method for interdigitated back-contact (IBC) silicon solar cells is reported. A patterned PEDOT:PSS seed layer was inkjet printed on the backsheet. After curing, the seed layer pattern was electroplated first with Cu and then with eutectic Sn-Bi. During lamination at 150 °C, the eutectic Sn-Bi alloy melts and provides good ohmic contact between the IBC solar cells and the electroplated Cu on the backsheet, thus simultaneously achieving metallization and interconnection. The method eliminates the need to form thick metal conductors on the IBC cells. Furthermore, the moderate conductivity of the PEDOT:PSS seed layer lines results in tapered Cu conductors with the finger height reducing as a function of distance from the contacted busbar. This tapered metal grid can reduce the mass of Cu required for a 1% resistive power loss by 24%.
ICA k-means based time series clustering analysis of online word-of-mouth

Online word-of-mouth activity is a very typical index of the lifecycle evolution model of a product, and understanding product lifecycle can help corresponding decision makers with their formulation of marketing strategies. In this paper, the data sets for the online comments on various types of products are studied; based on management theory and economics theory, and by applying such methods as independent component analysis (ICA) and clustering, the online word-of-mouth activities for different products or similar products are analyzed through clustering; meanwhile, the lifecycle curves for some representative products are extracted, and typical lifecycles are profoundly analyzed. This paper aims to effectively improve the effect of online word-of-mouth information on e-commerce marketing management and decision making, and to obtain internationally advanced achievement in corresponding field.
Genotype Imputation for African Americans Using Data From HapMap Phase II Versus 1000 Genomes Projects

Genotype imputation provides imputation of untyped single nucleotide polymorphisms (SNPs) that are present on a reference panel such as those from the HapMap Project. It is popular for increasing statistical power and comparing results across studies using different platforms. Imputation for African American populations is challenging because their linkage disequilibrium blocks are shorter and also because no ideal reference panel is available due to admixture. In this paper, we evaluated three imputation strategies for African Americans. The intersection strategy used a combined panel consisting of SNPs polymorphic in both CEU and YRI. The union strategy used a panel consisting of SNPs polymorphic in either CEU or YRI. The merge strategy merged results from two separate imputations, one using CEU and the other using YRI. Because recent investigators are increasingly using the data from the 1000 Genomes (1KG) Project for genotype imputation, we evaluated both 1KG‐based imputations and HapMap‐based imputations. We used 23,707 SNPs from chromosomes 21 and 22 on Affymetrix SNP Array 6.0 genotyped for 1,075 HyperGEN African Americans. We found that 1KG‐based imputations provided a substantially larger number of variants than HapMap‐based imputations, about three times as many common variants and eight times as many rare and low‐frequency variants. This higher yield is expected because the 1KG panel includes more SNPs. Accuracy rates using 1KG data were slightly lower than those using HapMap data before filtering, but slightly higher after filtering. The union strategy provided the highest imputation yield with next highest accuracy. The intersection strategy provided the lowest imputation yield but the highest accuracy. The merge strategy provided the lowest imputation accuracy. We observed that SNPs polymorphic only in CEU had much lower accuracy, reducing the accuracy of the union strategy. Our findings suggest that 1KG‐based imputations can facilitate discovery of significant associations for SNPs across the whole MAF spectrum. Because the 1KG Project is still under way, we expect that later versions will provide better imputation performance. Genet. Epidemiol. 36:508‐516, 2012. © 2012 Wiley Periodicals, Inc.
Allo‐HLA Cross‐Reactivities of Cytomegalovirus‐, Influenza‐, and Varicella Zoster Virus–Specific Memory T Cells Are Shared by Different Healthy Individuals

Virus‐specific T cells can recognize allogeneic HLA (allo‐HLA) through TCR cross‐reactivity. The allospecificity often differs by individual (private cross‐reactivity) but also can be shared by multiple individuals (public cross‐reactivity); however, only a few examples of the latter have been described. Because these could facilitate alloreactivity prediction in transplantation, we aimed to identify novel public cross‐reactivities of human virus‐specific CD8+ T cells directed against allo‐HLA by assessing their reactivity in mixed‐lymphocyte reactions. Further characterization was done by studying TCR usage with primer‐based DNA sequencing, cytokine production with ELISAs, and cytotoxicity with 51chromium‐release assays. We identified three novel public allo‐HLA cross‐reactivities of human virus‐specific CD8+ T cells. CMV B35/IPS CD8+ T cells cross‐reacted with HLA‐B51 and/or HLA‐B58/B57 (23% of tetramer‐positive individuals), FLU A2/GIL (influenza IMP[58‐66] HLA‐A*02:01/GILGFVFTL) CD8+ T cells with HLA‐B38 (90% of tetramer‐positive individuals), and VZV A2/ALW (varicella zoster virus IE62[593‐601] HLA‐A*02:01/ALWALPHAA) CD8+ T cells with HLA‐B55 (two unrelated individuals). Cross‐reactivity was tested against different cell types including endothelial and epithelial cells. All cross‐reactive T cells expressed a memory phenotype, emphasizing the importance for transplantation. We conclude that public allo‐HLA cross‐reactivity of virus‐specific memory T cells is not uncommon and may create novel opportunities for alloreactivity prediction and risk estimation in transplantation.
A ‘marker switch’ approach for targeted mutagenesis of genes in Schizosaccharomyces pombe

The completion of the Schizosaccharomyces pombe genome sequencing project has led to a dramatic acceleration of gene characterization in this system. Once a gene has been identified, the challenge then comes in using reverse genetics to generate a range of mutants in this gene of interest so that the powerful genetics and wealth of genetic backgrounds available in Sz. pombe can be exploited to study the function of the newly identified molecule. Beyond simple PCR‐tagging approaches, the high frequency with which illegitimate recombination occurs in Sz. pombe has made the manipulation of some loci complex, time consuming and a process of trial and error. Here we describe a simple ‘marker switch’ approach that enables the rapid selection of integration events at the locus of interest from an excessive background of integration at heterologous sites. We use the generation of temperature‐sensitive mutations in the plo1+ gene to validate this approach. Copyright © 2003 John Wiley & Sons, Ltd.