Miracle-dz/UniFAR-FTUs huggingface dataset:
A Cost Comparison of Biologic Treatment Regimens for Metastatic Colorectal Cancer in Italy

Introduction Bevacizumab is a monoclonal antibody, which, in association with combination chemotherapy regimens, has been shown to be active in metastatic colorectal cancer. Other biologic agents active in the same setting are cetuximab and panitumumab, both of which are monoclonal antibodies directed against the antiepidermal growth factor receptor. The objective of this study was to compare treatment costs of first-line regimens for metastatic colorectal cancer in Italy. Methods A set of first-line regimens was considered, according to the Italian Association of Medical Oncology and the European Society for Medical Oncology guidelines. A targeted review of the literature was undertaken to identify clinical study references for treatment regimens. The total cost of a regimen was calculated in the perspective of the Italian healthcare system summing up drugs, administration, and adverse event costs, based on year 2016 prices and tariffs. Results Bevacizumab 7.5 mg + capecitabine was the least expensive regimen, with a total cost of €16,754 per patient. When we consider regimens based on FOLFOX, bevacizumab 5 mg + FOLFOX4 was the least expensive (€32,709 per patient), compared to panitumumab + FOLFOX4 (€42,815), cetuximab + FOLFOX4 (€42,725), and cetuximab + FOLFOX (€37,995). If we consider combination regimens based on FOLFIRI, the association of FOLFIRI and bevacizumab was less expensive than regimens that included cetuximab (€28,389 for bevacizumab 5 mg + FOLFIRI and €35,310 for cetuximab + FOLFIRI). Conclusions From the perspective of the Italian health care system, bevacizumab appears to be a convenient option among the first-line regimens for metastatic colorectal cancer. Further study, based on real-world evidence, would be necessary to confirm this result.
Self-Reported Barriers to Quality Physical Education by Physical Education Specialists in the Island of Puerto Rico

The purpose of this study was to determine which barriers physical education teachers in the Island of Puerto Rico perceive to influence their teaching of the established physical education curriculum. The instrument Perceived Barriers to Teach Survey, a modification of the Opportunities to Learn instrument (2010) from NASPE was used to collect data from a stratified sample of 600 physical education teachers from all the school levels in Puerto Rico. Five-point Likert-type scales and openended questions were used to measure respondents’ perceptions regarding barriers to teach the established curriculum.
Severe Isotype-Matched Immunosuppression (IMI) as a Potential Risk Factor for Progression of MGUS Patients.

BACKGROUND Monoclonal gammopathy of undetermined significance (MGUS) precedes multiple myeloma in virtually every case. However, only a small percentage will progress and at very different rates. In addition, recent data have suggested that MGUS is associated with other comorbidities including infections, suggesting impaired immune function in some MGUS patients. Therefore, we aimed at assessing the value of isotype-matched immunosuppression (IMI; e.g., suppression of an IgAκ in an IgAλ patient), a type of immunosuppression more specific than classical immunoparesis (IP; e.g., IgG and/or IgM suppression in an IgA patient), as a prognostic marker for MGUS progression. METHODS The Hevylite assay was used to assess IMI and immunoglobulin ratios in 307 serum samples from a cohort of 248 MGUS patients. Follow-up clinical records were available for 154 individuals. RESULTS A greater incidence of IMI (51%) over classical IP (37%) was observed, although both show a progressive increase with higher risk groups. Survival analysis of 154 patients showed that severe IMI (>50% suppression) differentiates 2 groups with significantly different time to progression (P = 0.024) while severe IP does not (P = 0.48). Also, a combination of severe IMI and involved monoclonal immunoglobulin >1.5g/dL by Hevylite (both variables found to be independent prognostic markers in multivariate analysis) identified a group of patients with a median time to progression 6-fold shorter than the remaining group (P < 0.0001). CONCLUSIONS These findings indicate a possible role for IMI in the malignant transformation of MGUS patients and a potential utility as a new risk factor.
Highly sensitive ultraviolet detector based on ZnO/LiNbO3 hybrid surface acoustic wave filter

Fabrication of a highly-sensitive UV detector based on the surface-acoustic-wave (SAW) principle is reported. The output voltage of the SAW oscillator constructed with a ZnO/LiNbO3 hybrid SAW filter was found to decrease linearly with increasing UV light intensity, and a very low intensity UV light of 10 μW/cm2 was detected easily. Our results show its potential use in wireless UV measurement systems.
Mental health, vulnerability and risk in police custody

Purpose The issue of mental health and policing is a subject that has been debated from a number of different perspectives. The purpose of this paper is to report on the findings of a case study that explored mental health difficulties and vulnerability within police custody. Design/methodology/approach The design of the study was qualitative, and it utilised telephone, semi-structured interviews with all levels of the custody staff. This approach was taken because the aim of the study was to explore how people in different roles within the organisation worked to safeguard vulnerable people in custody. Findings The findings from this study identified a number of interesting themes that could be explored further in later studies. Overall, the respondents expressed frustration that vulnerable people find themselves in police custody for low-level crime, when it could have been avoided with improved mental health services in the community. Additionally, the findings demonstrated that despite the processes that are designed to safeguard the detainee, tensions still exist including, timely access to mental health assessments, appropriate training and support for staff and the use of appropriate adults. Research limitations/implications Although the study was small in scale, the custody facility delivered detainee facilities for about 5,000 individuals per year. The research and information obtained supported the police lead for mental health to identify opportunities for improving the customer journey, as well as recognising the need for further research to identify how officers and staff relate to vulnerable individuals in contact with the police service. Originality/value Despite the limitations of the study, the findings have captured interesting data from a range of professionals working in one police custody suite, and therefore it presents a holistic overview of some key issues around mental health, vulnerability and safeguarding within the context of police custody.
What Influences the Skill of Climate Models over the Continents

Climate modeling groups from four continents have submitted simulations as part of phase 5 of the Coupled Model Intercomparison Project (CMIP5). With climate impact assessment in mind, we test the accuracy of the seasonal averages of temperature, precipitation, and mean sea level pressure, compared to two observational datasets. Nondimensional skill scores have been generated for the global land and six continental domains. For most cases the 25 models analyzed perform well, particularly the models from Europe. Overall, this CMIP5 ensemble shows improved skill over the earlier (ca. 2005) CMIP3 ensemble of 24 models. This improvement is seen for each variable and continent, and in each case it is largely consistent with the increased resolution on average of CMIP5, given the correlation between scores and grid length found across the combined ensemble. From this apparent influence on skill, the smaller average score for the 13 Earth system models in CMIP5 is consistent with their mostly lower resolution. T.
THE EFFECT OF HUMAN RESOURCE COMPETENCY ON FINANCIAL MANAGEMENT SYSTEM EFFECTIVENESS IN HEALTH ORIENTED CIVIL SOCIETY ORGANIZATIONS

Purpose: The purpose of the study was to establish the extent to which human resource competency affects the financial management system effectiveness in health oriented civil society organizations. Methodology: The study was conducted through a cross sectional descriptive survey. The target population of the study was 1065 Nongovernmental organizations in Kenya. The accessible population refers to the 606 Nongovernmental organizations located in Nairobi County. A sample of 10% equivalent to 61 Nongovernmental organizations was selected from the Nongovernmental organizations located in Nairobi County. The respondents were financial managers in every selected Nongovernmental organization. Data was collected by use of a questionnaire and was analyzed by use of inferential and descriptive statistics. Descriptive statistics included frequencies and means. Inferential statistics included correlation, regression and ANOVA analysis. The tool for data analysis was the Statistical Package for Social Sciences (SPSS) version 20. The results were presented using tables and pie charts. Results: Study results show that the majority of respondents agreed with the statement that managers empower their employees at the lowest hierarchy who must be competent to achieve the organizational goals and objectives. Unique contribution to theory, practice and policy : The study recommends that human resource management must be fully functional in a company with continuous training of the staff to ensure up to date competences and increased knowledge in financial management.
An investigation of passive antibody and its effects on porcine epidemic diarrhea virus infection

vi CHAPTER 1. GENERAL INTRODUCTION . 1 References . 2 CHAPTER 2. HISTORICAL AND CONTEMPORARY ASPECTS OF MATERNAL IMMUNITY IN SWINE . 3 Abstract . 3 Introduction . 4 The recognition of maternal immunity . 4 Why are piglets born agammaglobulinemic? 8 Anatomy and physiology of lactation . 11 Swine mammary gland anatomy . 11 Mammogenesis . 11 Lactogenesis . 14 Immunological functions of mammary secretions . 16 Cellular components in swine mammary secretion . 16 Antibodies in swine mammary secretions . 19 Transport of antibody into mammary secretions . 20 Acquisition of maternal immunity by the neonatal piglet . 22 Maternal immunity and swine health: past, present, and future applications . 24 References . 27 Table . 46 Table 1. Pathogens against which maternal immunity can provide protection to piglets . 46 CHAPTER 3. DOES CIRCULATING ANTIBODY PLAY A ROLE IN THE PROTECTION OF PIGLETS AGAINST PORCINE EPIDEMIC DIARRHEA VIRUS? 47 Abstract . 47 Introduction . 48 Materials and Methods . 50 Experimental design. 50 Porcine epidemic diarrhea virus (PEDV) inoculum . 50 Animals and animal care . 51 Implementation of the experiment . 52 Biological sample collection . 54 Coronavirus reverse-transcriptase polymerase chain reactions (rRT-PCR) . 55 Analysis 59
Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): bovine tuberculosis

Abstract Bovine tuberculosis has been assessed according to the criteria of the Animal Health Law (AHL), in particular criteria of Article 7 on disease profile and impacts, Article 5 on the eligibility of bovine tuberculosis to be listed, Article 9 for the categorisation of bovine tuberculosis according to disease prevention and control rules as in Annex IV and Article 8 on the list of animal species related to bovine tuberculosis. The assessment has been performed following a methodology composed of information collection and compilation, expert judgement on each criterion at individual and, if no consensus was reached before, also at collective level. The output is composed of the categorical answer, and for the questions where no consensus was reached, the different supporting views are reported. Details on the methodology used for this assessment are explained in a separate opinion. According to the assessment performed, bovine tuberculosis can be considered eligible to be listed for Union intervention as laid down in Article 5(3) of the AHL. The disease would comply with the criteria as in Sections 2, 3, 4 and 5 of Annex IV of the AHL, for the application of the disease prevention and control rules referred to in points (b), (c), (d) and (e) of Article 9(1). The main animal species to be listed for bovine tuberculosis according to Article 8(3) criteria are several mammal species, as indicated in the present opinion.
Clot Retention - A Simple New Method of Evacuation with Out Toomey's or Ellick's: A Clinical

Background: The purpose of this clinical study was to assess whether our new method of clot evacuation is useful and better compared to conventional methods clot retention in the urinary bladder is a most common problem in surgical and non-surgical cases. Based our experience of 122 cases managed in 26 years. We discuss some guide lines which make this a safer and easier to perform. Materials and Methods: During the period of June 1990 to June 2015, 122 cases of clot retention were treated. The nonsurgical causes are upper tract bleeding, drug-induced bleeding, post-traumatic bleeding, and hemato-chyluria. The Surgical causes are the most common is post transurethral resection of the prostate bleeding. Results: On reviewing the cases 115 males and 7 cases for females, it was found this method very simply and does not require any evacuator or syringe. This method easily adoptable and acceptable and no training are required. Conclusion: Clot retention in the urinary bladder is the most common problem in surgical and non-surgical cases. Our technique of simple Venky’s Suction and Nelton’s catheter will help without any extra expenditure.
Dengue NS1 Antigen for Early Detection of Dengue Infection

Dengue virus infection has emerged as a notable public health problem in recent decades in term of the mortality and morbidity associated with it (Neralwar et al., 2015). It is the most common arboviral illness in humans (Amol Hartalkar et al., 2015). Dengue (DEN) virus belongs to the genus Flaviviruses, and consists of four serotypes: serotype 1 (DEN-1), serotype 2 (DEN-2), serotype 3 (DEN-3), and serotype 4 (DEN-4) (Aditi Garg et al., 2015). Infection to one serotype confers immunity only to that particular infecting serotype. Subsequent infection with one of the three remaining serotypes results in immune-enhanced disease in the form of severe hemorrhagic fever or dengue shock syndrome (Purimitla Usha Rani et al., 2017). Worldwide, an estimated 2.5 billion people are at risk of infection. It is estimated that more than 50 million infections occur each year, of which 500,000 hospitalizations are of dengue haemorrhagic fever, mainly among children, with the case fatality rate exceeding 5% in some areas (Prakash Babaliche et al., 2015). Dengue is known in India since 1940s, but the disease is very limited in its spread. Dengue is becoming rampant in many states of southern International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 6 Number 10 (2017) pp. 2054-2058 Journal homepage: http://www.ijcmas. com
Les changements organisationnels augmentent-ils les risques psychosociaux des salariés ?: Une analyse sur données couplées

Cet article propose, a partir de l’enquete Changements Organisationnels et Informatisation 2006, une evaluation non parametrique de l’impact des changements organisationnels ou technologiques sur les risques psychosociaux des salaries. La nature couplee de cette enquete permet de mesurer les changements au niveau salarie et entreprise. Les risques psychosociaux sont pris en compte en suivant une methodologie recommandee par le rapport Nasse-Legeron et a sa suite le college Gollac. Nous montrons que l’analyse de l’effet des changements organisationnels sur les risques psychosociaux n’est pas aisee et depend de la matiere dont ces changements sont mesures. Ainsi, nous montrons qu’a moyen terme les changements organisationnels declares par les entreprises n’ont pas d’impact alors que ceux declares par les salaries ont un impact sur les risques psychosociaux.
Supporting children with special educational needs (SEN): An introduction to a 3-tiered school-based occupational therapy model of service delivery in the United Kingdom

ABSTRACT In the last 30 years, cumulated practice- and research-based evidence highlight that the collaboration between occupational therapists, nursery/school staff, parents and other professionals involved is the primal importance in supporting children with special educational needs through developing an integrated therapy programme. This clinical practice article aims at introducing a 3-tiered school-based occupational therapy model of service delivery with examples of clinical application used in the United Kingdom (UK). Challenges in implementing this model, different factors of good practice and recommendations for future development are discussed in order to further refine and validate this model.
A Study of Corticospinal Tract Remodelling in Adult Rats That Sustained Unilateral Cortical Ablation at Birth

38 Int rod uc t ion. 3 9 Materials and Methods. 41 Results. 44 Injection Sites. 44 Normal Adult Rats. • . 44
A Decade Later, Continued Transformation of Transcatheter Aortic Valve Replacement

Access at: www.USCjournal. com Severe aortic valve stenosis (AS) is a chronic, progressive illness that confers significant morbidity and mortality. Once symptomatic, patients with severe AS will ultimately succumb to the disease if it is not promptly corrected. Historically, surgical aortic valve replacement (SAVR) served as the exclusive therapeutic option to correct this mechanical problem. However, in 2002, Alain Cribier performed the first-in-man percutaneous implantation of a bioprosthetic aortic valve. Since this pivotal moment in the field of structural heart disease, transcatheter aortic valve replacement (TAVR) has developed into a contemporary, effective treatment option for severe AS. Multiple large, randomized clinical trials have demonstrated the superiority of TAVR versus medical therapy in the extreme surgical risk patient population, as well as the comparability of TAVR versus SAVR in all but the lowest surgical risk population to date. Since 2002, the equipment, techniques, and performance of TAVR continue to transform at a rapid pace. Yet, considerable work remains to fully eliminate the known complications of percutaneous valve replacement, including paravalvular leak and complete heart block requiring permanent pacemaker implantation, and to clearly determine the durability of transcatheter heart valves (THV). Furthermore, clinicians continue to seek innovative methods to minimize peri-procedural sedation, reduce hospital length of stay, and optimize cost effectiveness. In this focused review, we summarize the evolution of balloon-expandable and selfexpanding THVs and highlight innovative valve platforms presently under investigation. We provide a timeline and summary of the landmark clinical trials showing favorable clinical outcomes following TAVR, as well as the evidence supporting its use in extreme, high, and intermediate surgical risk subgroups. We also emphasize exciting developments in peri-procedural TAVR management and adjunctive technological advancements that continue to revolutionize the field.
The Use of Continuous Monitoring of Heart Rate as a Prognosticator of Readmission in Heart Failure Patients

In this study we validated the accuracy of heart rate measurements of two consumer-grade heart rate and activity tracking wearable devices in 8 healthy participants. In a clinical setting and using the Holter monitor as the reference, participants exercised on a stationary bike for 10 minutes with a 10-watts step protocol. The two devices reported better correlation with the Holter monitor at higher workload levels, hence, at higher heart rates with a 90% confidence interval for overall measurement accuracy. We also examined the feasibility of the two devices in remote monitoring 8 heart failure patients (NYHA II-NYHA III) for two weeks. The two devices reported lower daily physical activity, lower total step count and higher resting heart rate for NYHA III patients when compared to NYHA II patients’ data. Therefore, with the wearable devices we differentiated different classes of heart failure based on heart rate and physical activity.
Pulmonary function testing and its evaluation in patients with Familial Mediterranean Fever

Introduction Familial Mediterranean Fever (FMF) is an autosomal recessive, chronic auto inflammatory disease that occurs in characteristic attacks with accompanying peritonitis, pleurisy, snynovitis and in rare cases, pericarditis [1]. FMF is commonly seen in Turkish, Arab, Armenian and Jewish populations living in the Mediterranean basin [2]. Symptoms of the disease typically appear between the ages of 5-15. The most striking characteristic of the disease Abstract
Clinical and epidemiological characteristics of children admitted with fever in emergency department with or without sepsis.

INTRODUCTION Sepsis is a major cause of childhood death worldwide. In developing countries, epidemiological data about sepsis is scarce. This study describes and compares the frequency of etiological agents and initial sites of infection in children with or without sepsis, identifying risk factors and assessing outcomes. METHODOLOGY Clinical and demographic data from patients < 13 years of age with reported fever in a pediatric emergency department were collected and registered in forms. Patients were classified as with or without sepsis according to Goldstein et al.'s criteria [6]. RESULTS Of 254 patients, 120 (47%) did and 134 (53%) did not meet the sepsis definition. Overall, the median age (IQR) was 1.7 (0.8-3.9) years, and 153 (60%) were boys. Patients with sepsis were older (2.8 [1.1-5.3] versus 1.3 [0.6-2.9] years; p < 0.001) and had sickle-cell disease more frequently (7.6% versus 0.8%; p = 0.007). By multiple logistic regression, age and sickle-cell disease were independently associated with sepsis. The most frequent initial infections were pneumonia (43.7%), diarrhea (17.3%) and cellulitis/adenitis (13.0%). The frequency of these did not differ when patients with or without sepsis were compared. Etiology was established in 57 (22.4%) patients, 32 (26.7%), and 25 (18.7%) with or without sepsis, respectively. Four (3.3%) patients died in the sepsis subgroup, whereas none died in the other subgroup. CONCLUSIONS Children who met the 2005 international consensus definition of sepsis showed differences in age and comorbidities (sickle-cell disease) upon admission and were more likely to die.