Miracle-dz/UniFAR-FTUs huggingface dataset:
Chicken fat and inorganic nitrogen source for lipase production by Fusarium sp. (Gibberella fujikuroi complex)

In this work, we report the production of lipases by a Fusarium sp. isolate (FCLA-MA41) from Atlantic Forest, using chicken fat and association of organic and inorganic nitrogen sources in submerged fermentation to seek economically attractive bioprocess. A 2-level, 4-factor Central Composite Design (CCD) and response surface methodology (RSM) were used to study the influence of the concentrations of chicken fat, (NH 4 ) 2 SO 4 , Triton X-100 and yeast extract as a nutrient supplement in Vogel minimum salt medium. RSM defined the region with the best response as consisting of the following combination of variables: chicken fat 15.0 mL/L, Triton X-100 15.0 g/L, ammonium sulfate 4.5 g/L and yeast extract 1.0 g/L. A validation study was performed according to the described concentrations and produced an enzymatic activity of 4.22 ± 0.35 U/mL. Considering the cost estimates of the nutrient medium optimized for lipase production, the production cost was $US 518.00/million Units of lipase. Keywords: Fungal enzyme, central composite design, chicken fat, ammonium sulfate, Triton X-100. African Journal of Biotechnology , Vol 13(12), 1393-1401
HOST DEFENSE PEPTIDES OF THE COAGULATION SYSTEM AND THEIR THERAPEUTIC POTENTIAL

Prevention and control of infectious diseases is seriously hampered by an increasing prevalence of bacteria that are resistant towards conventional antibiotics. Resistant bacteria are often the root cause of infections that trigger the complex clinical syndrome called sepsis, which is a concern for high morbidity and mortality. Despite extensive basic research and clinical studies, treatment of sepsis remains challenging due to an uncontrolled immune response mediated by various phagocytic cells, and the coagulation and complement cascades. Emerging evidence suggests that host defense peptides (HDPs) may be potential lead structures in sepsis treatment due to their ability to modulate innate immune responses as well as being directly antimicrobial. From that perspective, this thesis aimed to identify and characterize the structure-activity relationships of small HDPs derived from serine proteases. In paper I and II, structural features, governing the antimicrobial activity of peptides derived from the C-terminal region of human serine proteases were identified. Moreover the potential of these peptides to modulate inflammatory responses caused by bacterial lipopolysaccharide (LPS) was investigated. Truncated forms of thrombin-derived C-terminal peptides exhibited length- and sequence-dependent antimicrobial and immunomodulating effects in vitro and in vivo as illustrated by increasing survival rates in mouse models of LPS-induced septic shock (paper I). Quantitative structure-activity relationship (QSAR) analysis utilizing biophysical, antimicrobial and immunomodulatory activities of peptides derived from evolutionary conserved C-terminal protease domains of serine proteases, disclosed a set of active peptides with potent selective membrane disrupting effects and promising therapeutic potential in animal models of LPS-induced septic shock (paper II). The data in Paper III demonstrate generation of antimicrobial peptides from the C-terminal region of the human coagulation factor X by proteolytic cleavage with human leukocyte elastase as well as P. aeruginosa elastase. The prototypic peptide RKG25 derived from the core region of the FX protease domain, exhibited multiple biological functions including, antimicrobial, anti-inflammatory and anticoagulant effects. In summary, the findings of multiple immunomodulatory functions of these novel HDPs provides a possible new approach for the development of treatments for bacterial infections. (Less)
Assessing the temporal learning account of the list-wide proportion congruence effect.

In this article, we assess an alternative account of a key experimental pattern thought to index top-down control. The list-wide proportion congruence effect is the well-documented pattern whereby the congruency effect (i.e., Stroop effect) is attenuated in lists containing mostly incongruent trials relative to lists containing mostly congruent trials. This pattern has typically been interpreted as a signature of a top-down control mechanism that modulates attention to the word dimension based on the global probability of encountering conflict between the word and color. However, Schmidt (2013a, 2013b) has proposed an alternative account that stresses relative temporal differences in responding between mostly incongruent and mostly congruent lists rather than relative differences in the control of attention. To assess this temporal learning account, we evaluate the evidence reported by Schmidt (2013a) and report new analyses of three previously published data sets in which a list-wide proportion congruence effect was observed after controlling for other potential confounds. These analyses targeted three key topics: effects of reaction time (RT) transformations, statistical support for temporal learning, and measurement of temporal rhythm. The evidence for the temporal learning account was neither strong nor consistent, and there was a highly significant list-wide proportion congruence effect that survived multiple attempts to control for temporal learning. Accordingly, we conclude that the temporal learning account is not currently a robust alternative to the global control account in explaining list-wide proportion congruence effects. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
Steady flow of viscoelastic fluids in microchannels under electrokinetic forces : PTT model with a Gordon – Schowalter convected derivative

Analytical solutions for the electro-osmotic flow of viscoelastic fluids, in microchannels in the presence of electrokinetic forces, obeying the Phan-Thien-Tanner model have been derived. This model uses the Gordon– Schowalter convected derivative, which leads to nonzero second normal stress difference. The channel is assumed to be very long and flat so that the problem can be approximated to that of flow between two parallel plates. Symmetric boundary conditions with equal zeta potentials at the walls are assumed. A nonlinear Poisson–Boltzmann equation governing the electrical double-layer field and a body force caused by the applied electrical potential field are included in the Navier–Stokes equations. Results are presented for the velocity distribution between the parallel plates of the microchannel for different parametric values assumed that characterize this flow.
Smart Drug Delivery Strategies Based on Porous Nanostructure Materials

The control of drug delivery can have a great effect on its efficacy. An optimum concen‐ tration range of drugs can play a significant role in the human body, and it can cause harm to humans when it exceeds the range of the drug concentration. Recently, a variety of drug deliveries and their targeted systems have been studied to minimize drug loss and maximize the amount of drug accumulated in the required area, thus increasing drug bioavailability. In addition, we should especially consider the prevention of its harmful side-effects in the human body. Innovative drug delivery systems based on biodegrada‐ ble, natural or synthetic polymers, microor nano-particles, lipoproteins, micelles, TiO2 nanotube arrays (TNTs), nanoporous anodic aluminum oxide (AAO), and so on were de‐ veloped, which combined magnetic targeting and stimulus-responsive in drug delivery systems. The composition of delivery carriers and the stimulus-responsive elements proved stimulus-responsive drug release as a smart drug delivery system.
Symbolic representation of the number three: a study with three-year-old children from contrasting socioeconomic environments

ABSTRACT The goal of the present study was to compare a range of aspects in children’s symbolic knowledge about the number three among two groups of three-year-olds from contrasting socioeconomic backgrounds. Every child was presented with five tasks that focused on the number three and that had cognitive demands of different complexity: expressing their age, reciting the conventional number series up to three, quantifying a collection of three, and two tasks requiring the use of visually presented quantitative information.The results showed the same order of difficulty of the tasks in both socioeconomic groups and a clear performance difference depending on socioeconomic background. These findings show that symbolic knowledge about the number three does not come in an all or none fashion. Rather, different aspects of this symbolic competence become apparent in response to different tasks, and seem to depend largely on the socioeconomic environment in which children develop.
Eurycoma longifolia aqueous extract increases sexual activities in male and female rats

Introduction Eurycoma longifolia Jack (Simaroubaceace), identified by its local name as Tongkat Ali is commonly found along the hilly jungle slopes of Malaysia. Pharmacological evaluations on this plant showed that it possessed antimalarial (Chan et al., 1986, 1989; Kardono et al., 1991; Ang et al., 1995), cytotoxic (Kardono et al., 1991; Morita et al., 1990, 1993; Itokawa et al., 1991), antiulcer (Tada et al., 1991) and antipyretic (Chan et al., 1995) properties. However, in Malaysia, it has gained notoriety as a male aphrodisiac since it is reputed to increase male prowess (Gimlette and Thompson 1977) and it is usually taken as a water decoction of roots. However, this is largely based on subjective rather than scientific verification. In vivo physiological studies employing sexually naive male rats treated with this extract exhibit increased sexual motivation; pendiculation, stimulated erectogenic effects and copulatory behaviour and improved sperm quality. However, the biochemical mechanism underlying its aphrodisiac properties especially with regard to its erectogenic effect is yet to be comprehended. In order to elucidate the mechanism of action of E. longifolia aqueous extract which has been reported to evince aphrodisiac properties, in vivo studies using male and female rats were carried out in this present study. Male and female Spraque Dawley rats were given various concentrations of aqueous extract of E. longifolia (0, 30, 60, 90, 150 mg/kg) orally for 7 days.
SOCIAL PARTICIPATION AND MENTAL HEALTH AMONG OLDER ADULTS IN IRAN

Objectives: Social participation is linked to healthy aging and the maintenance of functional independence in older individuals. This study aimed to investigate the relationship between social participation and orderly’s mental health . Method: Totally 380 people, aged over 60 residing in city of Hamadan were participated in the study. The participants completed a researcher-tailored inventory assessing their social participation and a GHQ28 questionnaire assessing their mental health. Required social and demographic data was also gathered. Results: Findings showed that the elderly, relatively, enjoyed good level of mental health. In general, mental health was significantly associated with social participation. However, when looking at subscales, only somatic and social performance had a significant positive relationship with social participation . Discussion: Social participation can be of effective factors on which policy makers and therapists can plan to improve the mental health of aged people .
Tailoring the Magnetic , Dielectric and Structural Properties of Cobalt Doped α-Fe 2 O 3 Nanoparticles *

In this work undoped and cobalt doped α-Fe2O3 nanoparticles (NPs) have been synthesized using sol-gel method. Dopant concentration is varied in the range of 2 to 8 wt%. Presence of diffraction peaks corresponding to (104), (110), (024) and (116) indicate the formation of α-Fe2O3 phase under as-synthesized conditions. XRD peak positions shift to relatively higher angles as compared to undoped NPs. Such shift in peak position might have been observed because of the lower ionic radius of cobalt (72pm) as compared to iron (74pm). SEM results confirm the formation of NPs with diameter less than 50nm. Undoped and cobalt doped iron oxide NPs show ferromagnetic behavior. Saturation magnetization increases as dopant concentration is increased to 8wt%. Slight decrease in dielectric constant is observed as frequency of applied field increases. However, as frequency of applied field increases to log f [Hz] >6.5 increase in dielectric constant is attributed to resonance effect. Tangent loss exhibits normal dispersion behavior i.e. decreases as frequency of applied field increases and becomes constant in high field region. Decrease in a.c. conductivity with increase in dopant concentration to 6wt% indicates that ionic transport is suppressed with cobalt doping in Fe2O3 nanoparticles
Two new deepwater sea anemones (Cnidaria: Anthozoa: Actiniaria) Sicyonis heliodiscus sp.n. (Actinostolidae) and Hormathia pacifica sp.n. (Hormathiidae) from Pacific

Sicyonis heliodiscus sp.n. and Hormathia pacifica sp.n. are described from the Taney Seamounts, NE Pacific. The species belonging to these two genera are known mainly from N Atlantic and Antarctic locations, and only a few species were recorded from the Pacific. Sicyonis heliodiscus sp.n. is a large species which has unusual exterior with short column hidden in live specimens under the wide oral disk and short marginal tentacles directed downward. It is a rare species, which have been observed only a few occasions during more than 25 years of research by the Monterey Bay Aquarium Research Institute. In contrast, Hormathia pacifica sp.n. is common at the Taney Seamounts. It has a common appearance for the genus and can be distinguished from other Hormathia species by a combination of features including the morphology of the body and cnidom. How to cite this article: Sanamyan N.P., Sanamyan K.E. , Lundsten L. 2015. Two new deepwater sea anemones (Cnidaria: Anthozoa: Actiniaria) Sicyonis heliodiscus sp.n. (Actinostolidae) and Hormathia pacifica sp.n. (Hormathiidae) from Pacific // Invert. Zool. Vol.12. No.2. P.131–149. doi: 10.15298/invertzool.12. 2.02
A Second Chance for First Impressions? Exploring the Context-(In)Dependent Updating of Implicit Evaluations

Research on implicit evaluation has yielded mixed results, with some studies suggesting that implicit evaluations are relatively resistant to change and others showing that implicit evaluations can change rapidly in response to new information. To reconcile these findings, it has been suggested that changes in implicit evaluations can be limited to the context in which counterattitudinal information was acquired. The current research expands on evidence for such context-dependent changes by investigating whether two cases of rapid change—updating caused by a reinterpretation of earlier information and by exposure to diagnostic information—generalize across contexts or, instead, are limited to the context in which the qualifying information was acquired. Two experiments found that both reinterpretation of earlier information and diagnostic counterattitudinal information led to changes in implicit evaluations that generalized across contexts. Implications for the malleability of implicit evaluations and context-dependent changes in implicit evaluations are discussed.
Change in Bacterial Diversity After Oil Spill in Argentina

During the past few decades, the impact and threat of oil pollution have resulted in extensive research. The anthropogenic origins of petroleum pollution (particularly via leak of coastal oil refineries) have raised interest among the scientific community in oil pollution distribution and its effects in the environment, mainly the marine environment. Tanker accidents are the major cause of oil pollution in marine environments. On December 26th, 2007, a tanker spilled approximately 100 m3 of crude oil into the sea, which impacted on Caleta Cordova coast, Argentina. Being part of Comodoro Rivadavia city, Caleta Cordova is a small village, where the community‘s local economy is based on artisanal fishing. Over the course of two months, local oil companies collaborated to manually clean the coast and hydrocarbon controls were carried out to monitor the hydrocarbon concentration. The province environmental authorities prohibited the use of chemical products to disperse hydrocarbons and the use of any other chemical product, including nitrogen and phosphorus salts to help biodegradation. On the day of the spill, there was an extraordinary high tide (6.4 m), which resulted in the definition of three areas of impact: the high area, which was the most difficult to clean up; the middle area, which was cleaned up with minimal problem and from where the samples in this study were taken; and the low tide line area. Petroleum hydrocarbon can be degraded by microorganisms such as bacteria, fungi, yeast, and microalgae (e.g.,Atlas, 1981) Bacteria are considered to represent the predominant agents of hydrocarbon degradation in the environment and hydrocarbondegrading bacteria are ubiquitous (Pucci et al 2009a, b). Since crude oil is made of a mixture of compounds, and since individual microorganisms metabolize only a limited range of hydrocarbon substrates (Britton, 1984), biodegradation of crude oil requires a mixture of different bacterial groups or consortia functioning to degrade a wider range of hydrocarbons (Bordenave et al., 2007; Cagnon et al., 2011). Contaminated marine environments are inhabited by a range of selected microorganisms able to tolerate and remediate pollutants that impacted the environment, leading to the dominance of pollutant-tolerant bacteria. Hence, bacterial communities in contaminated sites are typically less diverse than those in nonstressed systems (Harayama et al., 2004). Another characteristic of marine environments is that the vast majority of bacteria (90–99%) are uncultivable (Amann et al., 1995); hence, the analysis of microbial communities that
Time series analysis and identification of rsn using GLM-ICA two class classifier

The functionally receptive regions of the brain had always been concealing themselves even from the functional MRIs. This induced the quest of finding an efficient algorithm to address the issue of functional localization of activated regions and classification of the active functional areas of the brain. A sample of 10 Healthy controls and 3 shaky hand septuagenarians, nine acquisitions was considered for this study. The fMRI of three motor imbalance subjects whose scan size was 128 × 128 × 23 and a total of 110 volumes accompanied by three acquisitions for each, who are on an average of 65 ± 3 years were subjected to examination. The conclusion derived from this commendable study was that the number of voxels awakened in the sensory motor network was more in tremulous subjects. Besides the activation of the sensory motor network, tightly localized spatial variations were observed in default mode network (DMN), auditory network, sensory motor and visual networks (medial, occipital), right and left executive control networks of these people. This lead to GLM-ICA two class classifier for decision support which performs pre-processing each rsfMRI scan, encompassing realignment, coregistration, normalisation and smoothing, Extracting independent components from smoothed output, Selecting highest Eigen vectors for retrenching the high-dimensionality of the gathered neuroimages time series, Evolving 2-class classifier using k-means algorithm. The proposed algorithm GLM-ICA two class classifier aided the classification of about 87.5% of the functional localization.
Three Message Traversal Schemes for Georouting in Wireless Sensor Network

Beaconless geographic routing algorithms forward packets towards a geographical destination reactively without the knowledge of the neighborhood. Such algorithms allow greedy forwarding, where only the next hop neighbor responds after a timer-based contention using only 3 messages (RTS, CTS and DATA) per forwarding step. However, existing contention-based schemes for recovery from greedy failures do not have this property. This paper shows that recovery is possible within this Threemessage scheme: the Rotational Sweep (RS) algorithm directly identifies the next hop after timer-based contention and constructs a traversal path that ensures progress after a greedy failure. It uses a traversal scheme (called Sweep Circle) that forwards a message along the α-shape of the network and provides recovery paths shorter or equal to the prominent face routing with Gabriel graph planarization. An alternative traversal scheme (called Twisting Triangle) provides even shorter routes on average, as shown by simulations. They both also reduce per node overall network contention delays. We will prove that both traversal schemes guarantee delivery in UDGs. They can also be used for boundary detection and improve path-length in conventional beacon-
Alignments of galaxy group shapes with large-scale structure

In this paper we analyse the alignment of galaxy groups with the surrounding large scale structure traced by spectroscopic galaxies from the Sloan Digital Sky Survey Data Release 7. We characterize these alignments by means of an extension of the classical two-point crosscorrelation function, developed by Paz et al. We find a strong alignment signal between the projected major axis of group shapes and the surrounding galaxy distribution up to scales of 30 Mpc h −1 . This observed anisotropy signal becomes larger as the galaxy group mass increases, in excellent agreement with the corresponding predicted alignment obtained from
The High Time Resolution Universe Pulsar Survey – XII. Galactic plane acceleration search and the discovery of 60 pulsars

We present initial results from the low-latitude Galactic plane region of the High Time Resolution Universe pulsar survey conducted at the Parkes 64-m radio telescope. We discuss the computational challenges arising from the processing of the terabyte-sized survey data. Two new radio interference mitigation techniques are introduced, as well as a partially-coherent segmented acceleration search algorithm which aims to increase our chances of discovering highly-relativistic short-orbit binary systems, covering a parameter space including potential pulsar-black hole binaries. We show that under a constant acceleration approximation, a ratio of data length over orbital period of ~0.1 results in the highest effectiveness for this search algorithm. From the 50 per cent of data processed thus far, we have re-detected 435 previously known pulsars and discovered a further 60 pulsars, two of which are fast-spinning pulsars with periods less than 30ms. PSR J1101-6424 is a millisecond pulsar whose heavy white dwarf (WD) companion and short spin period of 5.1ms indicate a rare example of full-recycling via Case A Roche lobe overflow. PSR J1757-27 appears to be an isolated recycled pulsar with a relatively long spin period of 17ms. In addition, PSR J1244-6359 is a mildly-recycled binary system with a heavy WD companion, PSR J1755-25 has a significant orbital eccentricity of 0.09, and PSR J1759-24 is likely to be a long-orbit eclipsing binary with orbital period of the order of tens of years. Comparison of our newly-discovered pulsar sample to the known population suggests that they belong to an older population. Furthermore, we demonstrate that our current pulsar detection yield is as expected from population synthesis.
Are Lesbians Women?

I argue that Mordque Wittig's view that lesbians are not women neglects the complexities involved in the composition of the category “woman. ” I develop an articulation of the concept “woman” in the contemporary United States, with thirteen distinct defining characteristics, none of which are necessary nor sufficient. I argue that Wittig's emphasis on the material production of “woman” through the political regime of heterosexuality, however, is enormously fruitful for feminist and queer strategizing.