Miracle-dz/UniFAR-FTUs huggingface dataset:
Extreme winds in the Western North Pacific

A statistical model for extreme winds in the western North Pacific is developed, the region on the Planet where tropical cyclones are most common. The model is based on best track data derived mostly from satellite images of tropical cyclones. The methods used to estimate surface wind speeds from satellite images is discussed with emphasis on the empirical basis, which, unfortunately, is not very strong. This is stressed by the fact that Japanese and US agencies arrive at markedly different estimates. On the other hand, best track data records cover a long period of time and if not perfect they are at least coherent over time in their imperfections. Applying the the Holland model to the best track data, wind profiles can be assigned along the tracks. From this annual wind speed maxima at any particular point in the region can be derived. The annual maxima, in turn, are fitted to a Gumbel distribution using a generalization Abild’s method that allows for data wind collected from multiple positions. The choice of this method is justified by a Monte Carlo simulation comparing it to two other methods. The principle output is a map showing fifty year winds in the region. The method is tested against observed winds from Philippine synoptic stations and fair agreement is found for observed and predicted 48–year maxima. However, the almost bias–free performance of the model could be fortuitous, since precise definitions of ’windspeed’ in terms averaging time, height above ground and assumed surface roughness are not available, neither for best tracks nor for the synoptic data. The work has been carried out under Danish Research Agency grant 2104-04-0005 “Offshore wind power” and it also covers the findings and analysis carried out in connection with task 1.6 of the project “Feasibility Assessment and Capacity Building for Wind Energy Development in Cambodia, The Philippines and Vietnam” during 2005-06 under contract 125-2004 with EU-ASEAN Centre of Energy. Approved by: Lars Landberg Checked by: Jakob Mann, Niels Jacob Tarp-Johansen In no event will Risø National Laboratory or any person acting on behalf of Risø be liable for any damage, including any lost profits, lost savings, or other incidental or consequential damages arising out of the use or inability to use the results presented in this report, even if Risø has been advised of the possibility of such damage, or for any claim by any other party.
Translation Efficiency and Degradation of ER-Associated mRNAs Modulated by ER-Anchored poly(A)-Specific Ribonuclease (PARN)

Translation is spatiotemporally regulated and endoplasmic reticulum (ER)-associated mRNAs are generally in efficient translation. It is unclear whether the ER-associated mRNAs are deadenylated or degraded on the ER surface in situ or in the cytosol. Here, we showed that ER possessed active deadenylases, particularly the poly(A)-specific ribonuclease (PARN), in common cell lines and mouse tissues. Consistently, purified recombinant PARN exhibited a strong ability to insert into the Langmuir monolayer and liposome. ER-anchored PARN was found to be able to reshape the poly(A) length profile of the ER-associated RNAs by suppressing long poly(A) tails without significantly influencing the cytosolic RNAs. The shortening of long poly(A) tails did not affect global translation efficiency, which suggests that the non-specific action of PARN towards long poly(A) tails was beyond the scope of translation regulation on the ER surface. Transcriptome sequencing analysis indicated that the ER-anchored PARN trigged the degradation of a small subset of ER-enriched transcripts. The ER-anchored PARN modulated the translation of its targets by redistributing ribosomes to heavy polysomes, which suggests that PARN might play a role in dynamic ribosome reallocation. During DNA damage response, MK2 phosphorylated PARN-Ser557 to modulate PARN translocation from the ER to cytosol. The ER-anchored PARN modulated DNA damage response and thereby cell viability by promoting the decay of ER-associated MDM2 transcripts with low ribosome occupancy. These findings revealed that highly regulated communication between mRNA degradation rate and translation efficiency is present on the ER surface in situ and PARN might contribute to this communication by modulating the dynamic ribosome reallocation between transcripts with low and high ribosome occupancies.
Polyphenol contents and thermal characteristics of freeze- dried date-pits powder

Food processing by-products may contain many valuable substances that can be used to produce value added products, for example dietary fiber, pigments, sugars, organic acids, flavors, antioxidant and antimicrobial substances. The date-pits is a by-product from date fruit processing industry that constitutes approximately 10% of the fruit mass and could thus be reused as ingredient for different value added products. The extraction, preservation and storage stability of these substances require knowledge on optimum conditions for their extractions as well as their thermal properties. The objectives of the present study were to determine the amount of total polyphenols extracted using various solvents at different temperatures (22, 45 and 60 C), to measure the sorption isotherm using isopiestic method and to determine the thermal characteristics of date-pits powder as a function of moisture content using Differential Scanning Calorimetry (DSC). Polyphenol contents in date-pits varied from 2162 mg gallic acid equivalents (GAE)/g date-pits when acetone–water, ethanol– water, methanol–water and water alone were used as solvents for extraction at temperatures 22, 45, and 60 C. The Isotherm modeled by BET and GAB models gave monolayer values of date-pits of 4.3 and 4.1 g/100 g dry-solids respectively, suggesting that date-pits powder contained low level of polar sites to bind the water molecules. The DSC thermogram of freeze-dried date-pits showed an endothermic peak due to the melting of oil, and a second endothermic peak for solids-melting (i.e. non-fat). The first shift indicated the glass transition (i.e. Tg) while the second exothermic shift after solids-melting indicated the interactions of the components in melted solids. The melting peak temperature was decreased due to the plasticization of solids with water and the melting enthalpy was increased with the increasing water content. Peak temperature was modeled by Flory–Huggins equation and the water–solids interaction parameter was estimated as 0.0068. The melting peak temperature increased exponentially with increasing heating rate and the data was fitted with Mehl–Johnson–Avrami and Kissinger models.
Sensor‐mediated granular sludge reactor for nitrogen removal and reduced aeration demand using a dilute wastewater

A sensor‐mediated strategy was applied to a laboratory‐scale granular sludge reactor (GSR) to demonstrate that energy‐efficient inorganic nitrogen removal is possible with a dilute mainstream wastewater. The GSR was fed a dilute wastewater designed to simulate an A‐stage mainstream anaerobic treatment process. DO, pH, and ammonia/nitrate sensors measured water quality as part of a real‐time control strategy that resulted in low‐energy nitrogen removal. At a low COD (0.2 kg m−3 day−1) and ammonia (0.1 kg‐N m−3 day−1) load, the average degree of ammonia oxidation was 86.2 ± 3.2% and total inorganic nitrogen removal was 56.7 ± 2.9% over the entire reactor operation. Aeration was controlled using a DO setpoint, with and without residual ammonia control. Under both strategies, maintaining a low bulk oxygen level (0.5 mg/L) and alternating aerobic/anoxic cycles resulted in a higher level of nitrite accumulation and supported shortcut inorganic nitrogen removal by suppressing nitrite oxidizing bacteria. Furthermore, coupling a DO setpoint aeration strategy with residual ammonia control resulted in more stable nitritation and improved aeration efficiency. The results show that sensor‐mediated controls, especially coupled with a DO setpoint and residual ammonia controls, are beneficial for maintaining stable aerobic granular sludge.
A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control

BACKGROUND & AIMS Hepatic innate immune control of viral infections has largely been attributed to Kupffer cells, the liver macrophages. However, also hepatocytes, the parenchymal cells of the liver, possess potent immunological functions in addition to their known metabolic functions. Owing to their abundance in the liver and known immunological functions, we aimed to investigate the direct anti-viral mechanisms employed by hepatocytes. METHODS Using lymphocytic choriomeningitis virus (LCMV) as a model of liver infection, we first assessed the role of myeloid cells by depletion prior to infection. We investigated the role of hepatocyte-intrinsic innate immune signaling by infecting mice lacking canonical NF-κB signaling (IKKβΔHep) specifically in hepatocytes. In addition, mice lacking hepatocyte-specific interferon-α/β signaling-(IFNARΔHep), or interferon-α/β signaling in myeloid cells-(IFNARΔMyel) were infected. RESULTS Here, we demonstrate that LCMV activates NF-κB signaling in hepatocytes. LCMV-triggered NF-κB activation in hepatocytes did not depend on Kupffer cells or TNFR1- but rather on TLR-signaling. LCMV-infected IKKβΔHep livers displayed strongly elevated viral titers due to LCMV accumulation within hepatocytes, reduced interferon-stimulated gene (ISG) expression, delayed intrahepatic immune cell influx and delayed intrahepatic LCMV-specific CD8+ T-cell responses. Notably, viral clearance and ISG expression were also reduced in LCMV-infected primary hepatocytes lacking IKKβ, demonstrating a hepatocyte-intrinsic effect. Similar to livers of IKKβΔHep mice, enhanced hepatocytic LCMV accumulation was observed in livers of IFNARΔHep, whereas IFNARΔMyel mice were able to control LCMV-infection. Hepatocytic NF-κB signaling was also required for efficient ISG induction in HDV-infected dHepaRG cells and interferon-α/β-mediated inhibition of HBV replication in vitro. CONCLUSIONS Together, these data show that hepatocyte-intrinsic NF-κB is a vital amplifier of interferon-α/β signaling pivotal for early, strong ISG responses, influx of immune cells and hepatic viral clearance.
Catalytic Cracking of Methyl Ester from Used Cooking Oil with Ni-Ion-Exchanged ZSM-5 Catalyst

Fossil crude reserves continue to decline, eventually leading to a reduced availability of fuel oil in Indonesia. Thus, the use of alternative plant-derived renewable energy sources, such as biodiesel should be considered. However, biodiesel as a fuel alternative has many drawbacks. In this study, biodiesel was cracked using a Ni-ZSM-5 catalyst to improve its quality. This work aimed to synthesize and characterize the Ni-ZSM-5 catalyst obtained from ion-exchange and catalytically crack methyl esters from used cooking oil. Three Ni-metal concentrations (1%, 2%, and 3%) were used for the ion-exchange of ZSM-5. Ni catalysts were then utilized for catalytic cracking at three temperatures (450 oC, 500 oC, and 550 oC). X-ray diffraction and scanning electron microscopy (SEM) analysis showed that the catalyst was in an aggregate form. SEM-energy-dispersive X-ray spectroscopy analysis indicated that Ni was successfully adsorbed by the catalyst. The gravimetry of the catalytically cracked product revealed that the highest oil fraction was obtained using 1% Ni catalyst at 450 oC. The largest chain obtained with this catalyst was diesel oil (C13-C19) with total 92.96% of covered peak area in the chromatogram/component quantity from gas chromatography.
Solving Bi-matrix Games in Tourism Planning Management under Rough Interval Approach

The aim of this article is to propose a novel and simple technique for solving bi-matrix games with rough intervals payoffs. Since the payoffs of the rough bi-matrix games are rough intervals, then its value is also a rough interval. In this technique, we derived four bilinear programming problems, which are used to obtain the upper lower bound, lower lower bound, lower upper bound and upper upper bound of the rough interval values of the players in rough bi-matrix games which we called in this article as 'solution space'. Moreover, the expected value operator and trust measure of rough interval have been used to find the α-trust equilibrium strategies and the expected equilibrium strategies of rough interval bi-matrix games. Finally, numerical example of tourism planning management model is presented to illustrate the methodologies adopted and solution procedure.
Gelidium amansii Attenuates Hypoxia/Reoxygenation-Induced Oxidative Injury in Primary Hippocampal Neurons through Suppressing GluN2B Expression

Oxidative stress is known to be critically implicated in the pathophysiology of several neurological disorders, including Alzheimer’s disease and ischemic stroke. The remarkable neurotrophic activity of Gelidium amansii, which has been reported consistently in a series of our previous studies, inspired us to investigate whether this popular agarophyte could protect against hypoxia/reoxygenation (H/R)-induced oxidative injury in hippocampal neurons. The primary culture of hippocampal neurons challenged with H/R suffered from a significant loss of cell survival, accompanied by apoptosis and necrosis, DNA damage, generation of reactive oxygen species (ROS), and dissipation of mitochondrial membrane potential (ΔΨm), which were successfully attenuated when the neuronal cultures were preconditioned with ethanolic extract of G. amansii (GAE). GAE also attenuated an H/R-mediated increase of BAX and caspase 3 expressions while promoting Bcl-2 expression. Moreover, the expression of N-methyl-d-acetate receptor subunit 2B (GluN2B), an extrasynaptic glutamate receptor, was significantly repressed, while synaptic GluN2A expression was preserved in GAE-treated neurons as compared to those without GAE intervention. Together, this study demonstrates that GAE attenuated H/R-induced oxidative injury in hippocampal neurons through, at least in part, a potential neuroprotective mechanism that involves inhibition of GluN2B-mediated excitotoxicity and suppression of ROS production, and suggests that this edible seaweed could be a potential source of bioactive metabolites with therapeutic significance against oxidative stress-related neurodegeneration, including ischemic stroke and neurodegenerative diseases.
The financial support for long-term elderly care and household saving behaviour pdfauthor=Asako Ohinata and Matteo Picchio

We analyse how the financial support for long-term elderly care affects the level of household savings. Using a difference-in-differences estimator, we investigate the 2002 Scottish reform, which introduced free formal personal care for all the elderly aged 65 and above residing in Scotland. Our semiparametric estimation technique allows the policy effects to be flexibly estimated across age groups. We find that the Scottish policy reduced the average household saving by about £7,200. Moreover, the estimated effects are heterogeneous across age groups of the head of household: these effects are particularly strong among those aged between 40 and 60. The largest effect is observed at age 49 with the reduction in the average household saving by £12,764.
SwarmNet: Towards Imitation Learning of Multi-Robot Behavior with Graph Neural Networks

In this paper, we propose SwarmNet – a neural network architecture that can learn to predict and imitate the behavior of an observed swarm of agents in a centralized manner. Tested on artificially generated swarm motion data, the network achieves high levels of prediction accuracy and imitation authenticity. We compare our model to previous approaches for modelling interaction systems and finally discuss an extension of SwarmNet that can deal with nondeterministic, noisy, and uncertain environments, as often found in robotics applications.
Enhancing Salt Tolerance of Cucumber Using Grafting and Some Bioregulators

Experiment was conducted in a greenhouse in El-Salehea Al-Gadeda, Sharqia Governorate during the two successive seasons of 2008/ 2009 and 2009/2010 to investigate the effect of grafting technique, bioregulators; salicylic acid (SA) at 0.5 & 1 mM, fulvic acid (FA) at 150 & 300 ppm and sea weed extract (SWE) at 2.5 & 5% in addition to osmoregulators (compatible solute); glycine betaine (GB) at 2.5 & 5 mM in improving salt tolerant of grafted cucumber plants (Cucumis sativus L. cv. falcon, Hybrid F1) under saline conditions. Grafting of cucumber on salt tolerance rootstock (Shintosa supreme pumpkin) significantly increased growth and fruits yield, relative water content (RWC) and antioxidant enzymes activity. Furthermore, grafting significantly increased chlorophyll, carotenoid, proline and total soluble protein concentrations. Grafting reduced membrane permeability and malondialdehyde (MDA) concentration in leaves of cucumber plants under salt stress conditions. Foliar application of SWE, SA, FA and GB significantly improved growth and yield parameters, and biochemical contents of grafted cucumber plants compared to untreated grafted plants under salt conditions. The superiority was due to SWE (5%) followed by FA (300 ppm) then GB (5 mM).
Effect of Lyophilized Xinshao Injection on Brain Circulation in Anesthetized Dogs

Objective To observe the effect of lyophilized Xinshao injection on brain circulation anesthetized dogs.Methods To measure BP and blood flow of vertebra artery and internal carotid artery by flow meter.Results Blood flow of vertebra artery and internal carotid artery increased markedly.Conclusion Lyophilized Xinshao injection can increase cerebral blood stream,reduce cerebral blood vessel resistance and improve it's circulation.
AN EXAMINATION OF PASS RATES FOR CANDIDATES WITHOUT ADVANCED DEGREES ON THE COMPUTERIZED CERTIFIED PUBLIC ACCOUNTANT (CPA) EXAM: ASSOCIATION TO ADVANCE COLLEGIATE SCHOOLS OF BUSINESS (AACSB)-ACCREDITED VS. UNACCREDITED INSTITUTIONS

This study examines pass rates on the computerized Certified Public Accountant (CPA) exam by comparing the results for candidates with bachelor’s degrees from the Association to Advance Collegiate Schools of Business International (AACSB)-accredited institutions to candidates with bachelor’s degrees from unaccredited institutions. The comparison includes both business-only-accredited and accounting-accredited institutions. When we examined computerized CPA exam passing rates for a four-year period (2005 to 2008), we found that candidates with bachelor’s degrees from accounting-accredited schools outperformed candidates with bachelor’s degrees from business-accredited only and unaccredited schools. Furthermore, candidates with bachelor’s degrees from business-accredited schools outperformed candidates with bachelor’s degrees from unaccredited schools. These results support previous findings from the paper-and-pencil and computerized formats of the CPA exam, which showed
On the identity and phylogenetic position of Dero indica (Clitellata: Naididae)

The identity and validity of the freshwater worm Dero indica (Clitellata: Naididae; Naidinae) has been debated, and it has been suggested that it is likely to be identical with D. digitata. In this study we combine a newly generated COI sequence of D. indica with available sequences from GenBank, to estimate the phylogeny of Dero using both Bayesian Inference and Maximum Likelihood. The trees show that D. indica is well separated from D. digitata, instead it is closest to D. vaga, but with low support. Furthermore, the analyses confirm the close relationship between Dero and Branchiodrilus found in previous studies, and indicates the presence of cryptic species in D. furcata and D. digitata.
A Study on Supervisor Satisfaction and Work-related Attitudes of Workers: Northern Thailand after the 2008 Global Financial Crisis *

At the outset of the 2008 Global Financial Crisis (here after will be referred to as 2008GFC) and subsequent world-wide economic recession which hit most industrialized nations, many industrial organizations adopted restructuring to counter the economic and financial squeeze. Due to high inter-dependency among countries and industries of present age, one could say that virtually every organisation, regardless of the industry or country, were all ill-affected by the recession. One industry and nation which particularly suffered heavily from the Crisis was tourism industry of Thailand. Tourism, which has the distinct characteristics of being a luxury good, has disadvantage as far as priority is concerned particularly to those whose very existence suddenly became quite uncertain. Especially when paired with highly volatile national instability as
OTT_A_222189 10165..10175

Department of Pathology of Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou 350014, People’s Republic of China; Department of Fujian Provincial Key Laboratory of Tumor Biotherapy, Fuzhou, Fujian 350014, People’s Republic of China; Department of Molecular Pathology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, Fujian 350014, People’s Republic of China; Department of Thoracic Surgery, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou 350014, People’s Republic of China; Department of Pathology of Zhejiang Cancer Hospital, Hanzhou 310022, People’s Republic of China
Ex-Vivo Treatment of Tumor Tissue Slices as a Predictive Preclinical Method to Evaluate Targeted Therapies for Patients with Renal Carcinoma

Clear cell renal cell carcinoma (ccRCC) is the third type of urologic cancer. At time of diagnosis, 30% of cases are metastatic with no effect of chemotherapy or radiotherapy. Current targeted therapies lead to a high rate of relapse and resistance after a short-term response. Thus, a major hurdle in the development and use of new treatments for ccRCC is the lack of good pre-clinical models that can accurately predict the efficacy of new drugs and allow the stratification of patients into the correct treatment regime. Here, we describe different 3D cultures models of ccRCC, emphasizing the feasibility and the advantage of ex-vivo treatment of fresh, surgically resected human tumor slice cultures of ccRCC as a robust preclinical model for identifying patient response to specific therapeutics. Moreover, this model based on precision-cut tissue slices enables histopathology measurements as tumor architecture is retained, including the spatial relationship between the tumor and tumor-infiltrating lymphocytes and the stromal components. Our data suggest that acute treatment of tumor tissue slices could represent a benchmark of further exploration as a companion diagnostic tool in ccRCC treatment and a model to develop new therapeutic drugs.