Miracle-dz/UniFAR-FTUs huggingface dataset:
Correction: Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target

In the supporting information section of this paper, the structures of oltipraz and safranin in Figure S1 were incorrect. The corrected fi gure may be found at Copyright: © 2007 Kuntz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The Sec1p/Munc18 (SM) protein, Vps45p, cycles on and off membranes during vesicle transport

Protein phosphatase 1 (PP1, Glc7p) functions in the final stage of SNARE-mediated vesicle transport between docking and fusion. During this process, trans-SNARE complexes, formed between molecules in opposing membranes, convert to cis-complexes, with all participants in the same lipid bilayer. Here, we show that glc7 mutant cells accumulate SNARE complexes. These complexes are clearly different from those found in either wild-type or sec18–1 cells as the Sec1p/Munc18 (SM) protein Vps45p does not bind to them. Given that PP1 controls fusion, the SNARE complexes that accumulate in glc7 mutants likely represent trans-SNARE complexes. Vps45p dissociates from the membrane in the absence of PP1 activity, but rapidly reassociates after its reactivation. These data reveal that SM proteins cycle on and off membranes in a stage-specific manner during the vesicle transport reaction, and suggest that protein phosphorylation plays a key role in the regulation of this cycle.
2-(4-Chlorophenyl)-3-methylsulfanyl-5-phenyl-1-benzofuran

In the title compound, C21H15ClOS, the 4-chlorophenyl ring is rotated out of the benzofuran plane, making a dihedral angle of 21.50 (6)°. The dihedral angle between the 5-phenyl ring and the benzofuran plane is 29.39 (6)°. The crystal studied was an inversion twin with a 0.65 (7):0.35 (6) domain ratio.
Tracking the Time Trends of Swedish Literature and Finding Characteristics of Authors by Using Topic Modelling

In this thesis, we discover the time trends in Swedish literature and characteristics of authors. We apply latent Dirichlet allocation (LDA), a method for topic modelling, to a corpus composed of 118 Swedish books and prose collected in Litteraturbanken. By using the LDA model, we observe two ndings: topics that focus on daily life, such as nature or family are frequently observed in the corpus, and peaks of topics in time trends result from books on the same topic written by several authors or books written by an author in a short time. Additionally, LDA is applicable to assessments of the characteristics of authors. We list the particular topics for nine authors with more than three books in the corpus by comparing the topic distribution of those authors to the topic distribution of the entire corpus.
Filogeni berdasarkan sekuens dna mitokondria gen Cytochrome oxidase I (Gen Coi) pada beberapa bangsa sapi lokal Indonesia

ASRI FEBRIANA. The Phylogeny Based on Mitochondrial DNA Sequences Cytochrome Oxidase I (COI) Gene in Several Indonesian Local Cattle. Supervised by DEDY DURYADI SOLIHIN and JAKARIA. The development of Indonesian cattle breeds derived from the original cattle such as bali cattle and also crossbreed which has become local cattle such as pesisir, madura, aceh, and filial ongole (PO) cattle. Indonesian local cattle has a high diversity such as color skin as well as body size. The approach of molecular markers can distinguish the Indonesian local cattle. This study was conducted to reconstruct the phylogenetic tree of several Indonesian local cattle based on mitochondrial DNA sequences of Cytochrome Oxidase I (COI) gene. The samples were used are bali, madura, aceh, pesisir, and PO cattle. In vitro amplification were done by using polymerase chain reaction (PCR) technique. 10 samples were successfully amplified and generated amplification products of 710 bp, but only eight samples were sequenced and analyzed succesfully. Phylogenetic analysis of Indonesian local cattle showed that bali cattle is separated from other cattles. Aceh, pesisir, madura dan PO cattle are located in the same group with Bos indicus. From these groupings showed that bali cattle have separate origins while the four others derived from zebu cattle group.
Effect of Trust on the Success of IT Reform in Chile

In an era of communication and information led by the Internet, the Chilean government understands that technological reform is imperative in order to be part of the global market. The government has recognized that many areas affecting electronic commerce are necessary to reform. However, the area related to trust, which in developed countries is seen as one of the most important barriers to the expected growth of electronic commerce, seems to be taken for granted. In this paper we examine how trust could affect the success of the technological reform project in Chilet, which factors are most important in developing trust, and how to measure their effect. The model is based on the Technology Acceptance Model (TAM) extended to explain the acceptance of electronic commerce in Chile.
Assessment of regional cerebral blood flow in patients with early and late onset alcohol dependence: a SPECT study

Amac: Alkol bagimliliginin beynin yapisi ve islevselligi uzerinde olumsuz etkileri vardir. Alkole baslangic yasi, alkol bagimlilarinin gruplandirilmasinda onemli bir parametredir. Bu calismanin amaci erken (EB) ve gec baslangicli (GB) alkol bagimlilarinda bolgesel beyin kan akimi (b-BKA) degerlerlerinin farkililik gosterip gostermedigini karsilastirmaktir. Yontemler: DSM-IV olcutlerine gore alkol bagimlilgi tanisi olan 33 erkek hasta ve 13 saglikli control calismaya alinmistir. Kortikal serebral kan akiminin bolgesel degerleri yuksek cozunurluklu Tc-99m-HMPA tek foton emisyon bilgisayarli tomografi kullanilarak degerlendirilmistir. Alkolik olgular sorunlu alkol baslangic yasina gore iki gruba ayrilmistir. Bulgular: Uc grup karsilastirildiginda alt frontal, alt temporal, alt sol oksipital ve orta sol frontal bolgelerde b-BKA farkliliklari saptanmistir (p<0.05). GB grupta control grubuna gore her iki alt frontal ve temporal bolgede azalmis b-BKA degerleri bulunmustur (p<0.005). GB grup EB grupla karsilastirildiginda, alt frontal ve temporal, alt sol oksipital ve orta sol frontal bolgelerde anlamli derecede azalmis b-BKA degerleri gostermistir (p<0.05). Sonuc: Bulgularimiz erken ayiklik donemindeki EB ve GB alkol bagimlilarinda b-BKA’nda farkliliklar oldugunu ortaya koymustur. Bu bulgular daha onceki calismalarda da belirtildigi uzere frontal lobun alkolizmin norobiyolojisinde kilit role sahip olduguna isaret etmektedir. Uzun sureli ayiklik doneminden sonra olcumlerin tekrarlanmasi alkol bagimlisi gruplar arasindaki farkliliklarin ortaya konmasinda yararli olacaktir.
Kinematic Comparative Analysis of Short Turns between Skilled and Unskilled Alpine Skiers

In skiing, a turn is made according to arc-of-curvature shaped sidecut. In other words, a turn is made by the sidecut, and edging reduces the radius of sidecut (Evans, Jackman, Otlaway 1974; Maruyama et al., 1994). In addition, such sidecut's role is identified by an edge angle as well as by edge pressure (Ichino, 1999). If a turn is made long, it is called 'long turn'. If made short, it becomes 'short turn' (Hyun, 2003). The ski plate itself represents if a turn is short or long as ski camber which makes sidecut and bending rebound. This study attempted to investigate if a human body's movement on the plate, which makes such turn maintains a long movement and creates a short turn. A long turn is a preceding work performed for a turn. A rotation which makes the shoulders face the uphill is conducted. Then, body weight is put on the outer foot, and knees are placed inwardly. Then, the edge angle is set (Maruyama et al., 1994). At the same time, as repulsion against centrifugal force according to velocity, a human body is leaned toward uphill, taking a direction of turn (inclination). After the inclination of basic parallel, angulation is performed for quick conversion to the next turn instead of making the whole body lean. Since inclination efficiency and axis make a big movement, angulation is performed along with inclination to avoid any shaking. Then, the pressure applied to one foot is regulated, preparing for the start and end of turn, radius of turn and next turn (Kang, Kim & Kim, 1999). However, a short turn greatly differs. A short turn is not just reduction of a long turn. In fact, it uses quite different turning KJSB Korean Journal of Sport Biomechanics 2019; 29(4): 219-226 http://dx.doi. org/10.5103/KJSB.2019. 29.4. 219 http://e-kjsb.org eISSN 2093-9752 ORIGINAL
Experiences of landing machine learning onto market-scale mobile malware detection

App markets, being crucial and critical for today's mobile ecosystem, have also become a natural malware delivery channel since they actually "lend credibility" to malicious apps. In the past decade, machine learning (ML) techniques have been explored for automated, robust malware detection. Unfortunately, to date, we have yet to see an ML-based malware detection solution deployed at market scales. To better understand the real-world challenges, we conduct a collaborative study with a major Android app market (T-Market) offering us large-scale ground-truth data. Our study shows that the key to successfully developing such systems is manifold, including feature selection/engineering, app analysis speed, developer engagement, and model evolution. Failure in any of the above aspects would lead to the "wooden barrel effect" of the entire system. We discuss our careful design choices as well as our first-hand deployment experiences in building such an ML-powered malware detection system. We implement our design and examine its effectiveness in the T-Market for over one year, using a single commodity server to vet ~ 10K apps every day. The evaluation results show that this design achieves an overall precision of 98% and recall of 96% with an average per-app scan time of 1.3 minutes.
Blueberry‐Enriched Diets Reduce Metabolic Syndrome and Insulin Resistance in Rats

Several studies suggest that anthocyanin intake could modify risk factors for metabolic syndrome. Blueberries are a rich, whole‐food source of anthocyanins. We tested the effect of a semi‐purified diet with added whole blueberry powder (2% w:w) or a carbohydrate‐matched control diet on factors of metabolic syndrome in the obesity‐prone Zucker Fatty rat, fed either a low fat (10% fat) diet or a high fat (45% fat) diet. After 90 days, both the low fat blueberry (LFB) and high fat blueberry (HFB) groups had reduced abdominal fat compared to controls, and the LFB group had reduced body weight and % fat mass. Both LFB and HFB groups had significantly reduced triglycerides, total cholesterol, fasting insulin, and fasting glucose. LFB and HFB also had improved glucose clearance, as measured by a glucose tolerance test. Given the improved glucose control, we then measured mRNA transcripts in skeletal muscle and retroperitoneal fat related to glucose and lipid uptake and metabolism by PCR Array. The results suggest that regular intake of blueberry reduced several key risk factors for cardiovascular disease and metabolic syndrome. Furthermore, these benefits were augmented when fed a low fat diet. Finally, blueberry diet conferred tissue changes in several genes related to lipid and glucose metabolism, which could support the in vivo results of greater insulin sensitivity and reduced fat accumulation.
Comparative Evaluation of Nutrient Contents of Fonio Offals of Digitatria Exilis and Digitariai Burua Speices

This experiment was conducted to compare the nutrient contents of fonio offals of Digitaria exilis and Digitariai burua offals. The results revealed that moisture between D. exilis and D. iburua offals was similar. However, D. iburua offal was higher in crude protein, ether extract and organic matter while D. exilis offal was higher in total ash, crude fibre, nitrogen free extract and dry matter. Calcium, potassium, zinc, copper and manganese were higher in D. exilis offal while D. iburua offal was higher only in phosphorus and iron. Both offals had similar contents of magnesium and sodium. The non-essential amino acids in D. exilis offal were glutamic acid, proline and serine while aspartic acid, cysteine, and glycine were in D. exilis offal. Essential amino acids in D. exilis offal were only alanine and leucine while arginine, histidine, isoleucine, lysine, methionine, phenylalanine, threonine and tyrosine were higher in D. iburua offal. D. exilis offal was higher in acid detergent fibre, acid detergent, phytate, oxalate and tannin while D. iburua offal was higher only in neutral detergent fibre. In conclusion, variation exists between the offal of D. exilis and D. iburua offals. D. iburua offal is predominantly higher in minerals, fibre and phytochemicals while D. iburua offal is higher in protein and essential amino acids. These offals are potential alternative fibre ingredients for livestock.
Physical Studies of tRNA in Solution

RNA-RNA interactions are formed and broken during the complex process of ribosome-mediated protein synthesis. In addition to the obvious interaction between the mRNA codons and the two tRNA anticodons, proposals have included binding between (1) tRNA and 5S RNA (Erdman 1976), (2) 5S RNA and 23S RNA (Herr and Noller 1975), (3) 23S RNA and 16S RNA (van Duin et al. 1976), (4) 16S RNA and tRNA (Noller and Chaires 1972), and (5) 16S RNA and mRNA during initiation (Shine and Delgarno 1974; Steitz and Jakes 1975). Clearly, a full understanding of the detailed mechanism of protein synthesis will require study of the equilibria and dynamics of RNA conformational changes. tRNA has been the most convenient and intensively studied system of this kind. Our knowledge of the molecular mechanisms of functional RNA conformational changes is in its infancy, usually limited to direct (Steitz and Jakes 1975) or indirect (Noller and Chaires 1972; Shine and Delgarno 1974; Herr and Noller 1975; Erdman 1976; van Duin et al. 1976) evidence that a pairing occurs. In contrast, conformational changes of isolated tRNA molecules have been intensively studied, especially between 1965 and 1975 (Crothers and Cole 1978). These early studies established the general conformational and ion-binding properties of tRNA and have now given way to more sophisticated techniques used to study specialized properties, of the kind reported by Reid and Hurd, Johnston and Redfield, and Potts et al. (all this volume). In particular, nuclear magnetic resonance (NMR) studies play a central role in present.
Estimation of agricultural soil properties with imaging and laboratory spectroscopy

Abstract Two EO-1 Hyperion images covering a Cicero Creek reservoir of central Indiana were analyzed using partial least squares (PLS) regression to estimate soil properties, including soil moisture, soil organic matter (SOM), total carbon (C), total phosphorus (P), total nitrogen (N), and clay content. PLS results for Hyperion image spectra were compared with those for laboratory measured spectra using several statistics, including the coefficient of determination ( R 2 ) and RPD (the ratio of standard deviation of sample chemical concentration to root mean square error). PLS was conducted in two phases: phase-1 used all samples for calibration to determine outliers and then models were recalibrated after outlier removal; phase-2 split the resulting samples from phase 1 into two subsets for calibration and validation, respectively. Based on R 2 and RPD values, the results from the phase-1 calibration indicate that PLS can estimate all soil properties from laboratory spectra and some soil properties from Hyperion spectra, and the phase 2 results suggest that PLS can predict SOM, total C, and total N using Hyperion reflectance spectra. It was found that spectral resolution has impacts on the PLS performance in estimating the soil properties considered in this investigation.
Isolated hepatic actinomycosis mimicking hepatocellular carcinoma: Case report and review

Actinomyces are a rare cause of the intra‐abdominal infection that results in chronic suppurative and infectious granulomatous disease. The liver is involved in 15% of cases with abdominal infection and comprises 5% of all cases. Major risk factors include previous surgery, abdominal trauma, gastrointestinal foreign body, gut lesions, and immunosuppression. Due to the insidious course of the disease, symptoms arise several months after onset of the disease. The diagnosis of liver actinomycosis relies on clinical manifestations and imaging findings. Thus, it is often misdiagnosed as a primary liver cancer or metastatic tumor. Here we describe a case of isolated hepatic actinomycosis that mimicked a hepatocellular carcinoma with pretreatment and posttreatment magnetic resonance imaging findings. The patient was cured with long‐term antibiotherapy.
Short-Term Effects, on Pressure Pain Threshold, After Applying Techniques Of Isquemic Compression and Traction-Compression- Stretching: A Randomized Clinical Trial

OBJECTIVE: To measure and compare the immediate effect in pressure pain threshold, after a single treatment of latent myofascial trigger point 1 (MTrP1) in the upper trapezius muscle, between Ischemic Compression technique and Traction- compression-stretching technique. MATERIAL AND METHODS: A randomized, double-blinded and controlled experimental trial was conducted. We assessed pre- and post-outcomes on thirty asymptomatic subjects who have latent MTrP1 in the upper trapezius muscle, which were randomized into three intervention groups: TCST, ICT and a control group. We used a pressure algometer to measure the latent trigger point PPT. the statistical analysis was performed using a 95% confidence level. The ANOVA test was used to analyze differences in pressure pain threshold. RESULTS: ANOVA analysis showed no significant differences (P>0.05), between the two intervention groups. He decides to accept the null hypothesis and reject the research hypothesis, concluded that both treatment techniques same immediate effect on the PPT. However, the effect size was found to be large for the Traction-compression-stretching technique group (d=0.84) and half to Ischemic Compression technique group (d=0.67). CONCLUSIONS: Both intervention techniques result in an immediate increase of PPT at MTrP1 in the upper trapezius muscle. The Traction-compression-stretching technique appeared to be more effective than Ischemic Compression technique in reducing pain sensitivity at that trigger point in asymptomatic subjects. Key words: Traction-compression-stretching, Ischemic Compression, trigger point, algometry, pressure pain threshold.
New Learning Strategies in Deep Models for Breast Cancer Screening

Breast cancer is one of the leading causes of death in women, responsible for over 508,000 deaths in 2011 alone. Early identification of the disease drastically increases odds of survival and screening tests through mammography are a crucial part of this process. Computer-aided detection and diagnosis (CAD) systems can help medical professionals analyze these screenings, increasing their accuracy and speed, allowing for more cases of the disease to be caught early. Recent efforts in applying deep learning techniques to lesion classification and detection in mammographic images have been extremely successful, obtaining state-of-the-art results in this problem, often without the need for the domain-specific feature engineering of more traditional approaches. However, these algorithms could be improved with larger amounts of labeled data which, for the case of mammograms, are not publicly available. In addition, public datasets are of varying quality and often captured with methods and equipment, making the transfer of machine learning models between them difficult. The other big challenge in this task is its inherent imbalance; both in the distribution of positive and negative cases and in the disproportionately large effect of a few pixels in the overall classification. Positive examples are rare and can only be discriminated by the presence of small abnormalities in very high-resolution images. Models must then be both efficient enough to quickly process large images and sensitive enough to pick up on the minute details that completely inform the desired classification. In addition, an exam can be composed of multiple images of the patient’s breasts, which are deformed in unique and complex ways by the mammogram capture process. Experts’ diagnoses of these exams take into account all of the views, often relating matching areas in the tissue in terms of symmetries or asymmetries. Computerized methods, on the other hand, have historically struggled with fusing the various views to produce unified predictions, particularly in the task of lesion detection. We propose a one-shot, multi-task, multi-input unified model for detection of lesions and mammogram malignancy classification in one or all four views of a typical mammogram exam and validate it using the INbreast dataset. We propose two methods of relating images from the same exam: through explicit mammogram alignment, and through the merging of features in the model’s architecture. Finally, we introduce a novel loss function for use in cluster detection and employ it to detecting clusters of microcalcifications.
Gaboxadol Normalizes Behavioral Abnormalities in a Mouse Model of Fragile X Syndrome

Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and autism. FXS is also accompanied by attention problems, hyperactivity, anxiety, aggression, poor sleep, repetitive behaviors, and self-injury. Recent work supports the role of γ-aminobutyric-acid (GABA), the primary inhibitory neurotransmitter in the brain, in mediating symptoms of FXS. Deficits in GABA machinery have been observed in a mouse model of FXS, including a loss of tonic inhibition in the amygdala, which is mediated by extrasynaptic GABAA receptors. Humans with FXS also show reduced GABAA receptor availability. Here, we sought to evaluate the potential of gaboxadol (also called OV101 and THIP), a selective and potent agonist for delta-subunit-containing extrasynaptic GABAA receptors (dSEGA), as a therapeutic agent for FXS by assessing its ability to normalize aberrant behaviors in a relatively uncharacterized mouse model of FXS (Fmr1 KO2 mice). Four behavioral domains (hyperactivity, anxiety, aggression, and repetitive behaviors) were probed using a battery of behavioral assays. The results showed that Fmr1 KO2 mice were hyperactive, had abnormal anxiety-like behavior, were more irritable and aggressive, and had an increased frequency of repetitive behaviors compared to wild-type (WT) littermates, which are all behavioral deficits reminiscent of individuals with FXS. Treatment with gaboxadol normalized all of the aberrant behaviors observed in Fmr1 KO2 mice back to WT levels, providing evidence of its potential benefit for treating FXS. We show that the potentiation of extrasynaptic GABA receptors alone, by gaboxadol, is sufficient to normalize numerous behavioral deficits in the FXS model using endpoints that are directly translatable to the clinical presentation of FXS. Taken together, these data support the future evaluation of gaboxadol in individuals with FXS, particularly with regard to symptoms of hyperactivity, anxiety, irritability, aggression, and repetitive behaviors.