Phenotypic and molecular characterization of a novel mouse model of neurofibromatosis type 2

S AND POSTERS 1. A novel murine model of NF2 with manifestations of human NF2 disease. Gehlhausen JR, Shew MA, Park SJ, Staser KW, Rhodes SD, Clapp DW, Yates CW. Children’s Tumor Foundation Annual NF meeting. Monterey, California (June, 2013). 2. A conditional model of schwannoma genesis that recapitulates human NF2 disease. Gehlhausen JR, Shew MA, Park SJ, Staser KW, Rhodes SD, Clapp DW, Yates CW. American Association for Cancer Research (AACR) annual meeting. Washington, DC (April 2013). 3. Normal Hematopoesis and Nf1-deficient myeloproliferative disease require Erk. Staser K, Park SJ, He YZ, Shew MA, Rhodes SD, Gehlhausen JR, Cerabonna D, Li Y, Nalepa G, Yang FC, Clapp DW. International Society for Experimental Hematology (ISEH) Annual Meeting, Amsterdam, The Netherlands (August 2012). 4. A novel murine model of Neurofibromatosis Type 2. Gehlhausen JR, Shew MA, Park SJ, Clapp DW, Yates CW. Children’s Tumor Foundation Annual Neurofibromatosis Meeting. New Orleans, LA (June 2012). 5. Development of a novel murine model of Neurofibromatosis Type 2. Gehlhausen JR, Shew MA, Park SJ, Clapp DW, Yates CW. International NF2 Conference, Manchester, UK (May 2012). 6. Myelopoiesis Requires Erk. Staser KW, Park SJ, He YZ, Shew MA, Gehlhausen JR, Rhodes SD, Li Y, Nalepa G, Yang FC, Clapp DW. Cancer Biology Training Consortium Annual Meeting, Tucson, AZ (November 2010) 7. Marrow repopulation and stem cell expansion requires ERK. Staser KW, Park SJ, He YZ, Shew MA, Gehlhausen JR, Rhodes SD, Li Y, Nalepa G, Yang FC, Clapp DW. International Society for Experimental Hematology (ISEH) Annual Meeting, Melbourne, Australia (September 2010). 8. Genetic evidence that myeloid proliferation requires ERK. Staser K, Park SJ, He YZ, Shew MA, Gehlhausen JR, Robinson MB, Li Y, Rhodes SD, Nalepa G, Yang FC, Clapp DW. American Society of Clinical Investigators (ASCI) Annual Meeting, Chicago, IL (April 2010). 9. Erk1 negatively regulates SCF-dependent mast cell function via Erk2 and β-catenin interactions. Staser K, Park SJ, Gehlhausen JR, Clapp DW. Howard Hughes Medical Institute Annual Scholars/Fellows Meeting, Bethesda, MD (May 2009). ORAL PRESENTATIONS 1. A conditional NF2 mouse model of schwannoma genesis that recapitulates human disease. Gehlhausen JR, Park SJ, Yates CW, Clapp DW. Abstract selected for oral presentation in plenary session. 2014 American Society for Clinical Investigation/American Physician Scientist Association Joint Meeting. Chicago, IL (April 2014). 2. A new murine model of Neurofibromatosis Type 2. Gehlhausen JR, Shew MA, Park SJ, Clapp DW, Yates CW. Selected platform presentation. Children’s Tumor Foundation Annual Neurofibromatosis Meeting. New Orleans, LA (June 2012). 3. Current Research in Neurofibromatosis Type 2. Gehlhausen JR, Shew MA, Park SJ, Yates CW, Clapp DW. Neonatology Working Group Seminar Series, Indianapolis, IN (July 2011). 4. Visualization of Fossil Records Using Microsoft Virtual Earth. Gehlhausen JR, Dalkilic MM, Microsoft eScience Workshop, Chapel Hill, NC (May 2007). PEER-REVIEWED PUBLICATIONS 1. Gehlhausen JR, Park SJ, Hickox AE, Shew M, Staser K, Rhodes SD, Menon KM,Lajiness JD, Mwanthi M, Yang X, Yuan J, Territo P, Hutchins G, Nalepa G, Yang FC,Conway SJ, Heinz MG, Stemmer-Rachamimov A, Yates CW, Clapp DW. A murine model of neurofibromatosis type 2 that accurately phenocopies human schwannoma formation. Hum mol genet. 2015 Jan 1;24(1):1-8. doi: 10.1093/hmg/ddu414. Epub 2014 Aug 11. PMID: 25113746; PMCID: PMC4262489. 2. Grzegorz Nalepa, Jill Barnholtz-Sloan, Rikki Enzor, Dilip Dey, Ying He, Jeff R. Gehlhausen, Amalia S. Lehmann, Yanzhu Yang1, Xianlin Yang, Shi Chen, Xiaowei Guan, Yanwen Chen, Jamie Renbarger, Feng-Chun Yang, Luis F. Parada, Wade Clapp. Tumor Suppressor CDKN3 Controls Mitosis. J Cell Biol. 2013 Jun 24;201(7):997-1012. doi: 10.1083/jcb.201205125. Epub 2013 Jun 17. PMID: 23775190; PMCID: PMC3691455. 3. Staser K,Park SJ, Rhodes SD,Zeng Y,He Y,Shew MA, Gehlhausen JR,Cerabonna D,Menon KM,Chen S,Sun Z,Yuan J, Ingram DA,Nalepa G,Yang FC, Clapp DW. Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk. J Clin Invest. 2013;123(1):329–334. doi:10.1172/JCI66167. PMCID: PMC3533306; PMID: 23221339. 4. Costello JC, Dalkilic MM, Beason SM, Gehlhausen JR, Patwardhan R, Middha S, Eads BD, Andrews JR. Gene networks in Drosophila melanogaster: integrating experimental data to predict gene function. Genome biol. 10 (2009), pp. R97. PMCID: PMC2768986; PMID: 19758432. 5. Costello JC, Schrider D, Gehlhausen JR, Dalkilic M. Data-driven ontologies. Pac Symp Biocomput. 2009:15-26. Prepublished on 2009/02/13 as DOI. PMID: 19213131.