Miracle-dz/UniFAR-FTUs huggingface dataset:
Recent Innovations and Comparison of Deep Learning Techniques in Malware Classiﬁcation : A Review

—The internet made an individuals life very easy and more productive, but there are some associated threats linked to the internet and devices. Malware is considered the most severe threat for decades to the digital world and malware variants identiﬁcation and classiﬁcation is the most vital and critical research problem. It is an invasive malicious code that accesses devices, information, and services without the permission, knowledge of the user. Researchers, analysts and antivirus companies are incessantly inventing and implementing new strategies to ﬁght back malware and its variants. In the last decade, one of the strategies is extensively used in the ﬁeld of malware detection and classiﬁcation is the deep learning methods using malware visualization. Results revealed that using visualization; malware can be identiﬁed, classiﬁed more promptly, efﬁciently, and accurately. Deep learning algorithms vary according to applications, architecture, and uses, so it is required to review and inspect the work based on deep learning to use malware visualization to know the recent approaches and innovations that have been established, to identify problems, current issues, challenges, and of course at the same time to motivate potential research directions. In this effort, an extensive survey of works that utilized deep learning methods using malware image representation, for malware classiﬁcation is reviewed with a detailed discussion on key methods such as data sets description, malware image representation strategies, and deep learning architectures of parameters, contributions, and limitations. A comparison of the reviewed work is presented based on various key factors.
332-337 Lorenzo-Morales J.pmd

This study describes the association of household water system contamination with the pathogenic Free-Living Amoeba (FLA) Naegleria fowleri and a case of fatal Primary Amoebic Meningoencephalitis (PAM) in a child from the state of Monagas in Venezuela. Amoebae were initially identified by microscopy from a sample of cerebrospinal fluid (CSF) from the child. Direct DNA extraction and specific PCR/sequencing for N. fowleri was also carried out from the same CSF sample. In order to determine a possible environmental source of infection, water samples from the water tank of the child’s home and also water bodies recently visited by the child and his family, were examined for the presence of N. fowleri by culture and PCR/sequencing. The results obtained from the collected water samples revealed that only the water tank of the house was positive for N. fowleri. PCR/sequencing showed that the strains isolated from the patient and the water tanks were 100 % identical. Therefore, the house water tank was confirmed as the source of infection in this case, possibly as a result of the occasional immersion of the child ́s head under the water while bathing. This case highlights a novel source of thermally polluted water and another threat of N. fowleri infection.
Use of respiratory quotients in assessment of aerobic work capacity

Oxygen uptake and carbon dioxide output were measured in 32 untrained subjects during exercise on the bicycle ergometer. It was shown that the work respiratory quotient (RQ) under standardized conditions can be used as a measure of physical fitness. ΔRQ (work RQ minus 0.75) increases logarithmically with the work load and maximal O2 uptake is reached at a ΔRQ value of 0.40. This observation offered the possibility of predicting the maximal O2 uptake of a person, based on the measurement of RQ during a single bicycle ergometer test at a submaximal load. For each work RQ between 0.95 and 1.15 a factor was presented, together with the aid of a simple equation, which gave a good approximation (generally better than ±10%) of the maximal O2 uptake.
New insights on the structure-function principles and design of quinoline antimalarial drugs

iii ACKNOWLEDGEMENTS . v DEDICATION . vii TABLE OF CONTENTS . viii LIST OF FIGURES. xii LIST OF TABLES . xv LIST OF SCHEMES . xvii LIST OF ABBREVIATIONS . xviii CHAPTER 1: GENERAL BACKGROUND . 1 1.1 Understanding Malaria; History & Distribution . 1 1.2 Plasmodium falciparum Life Cycle . 4 1.3 Physiology of the Malaria Parasite . 6 1.3. 1 Parasite Anatomy . 6 1.3. 2 Hemoglobin Uptake and Degradation . 8 1.3. 3 Deleterious Effects of FPIX . 9 1.3. 4 FPIX Detoxification via Hz Crystallization . 14 1.4 Classification of Antimalarial Chemotherapeutic Agents . 15 1.4. 1 Classification by Biological Activity . 15 1.4. 2 Structural Classification . 18 1.5 Quinoline Antimalarial Drugs: Mode of Action against Plasmodia . 20 1.6 Resistance to Quinoline Based Antimalarial Drugs . 21
Visualization and detection of coupling in time series by order recurrence plots

We introduce a new method to visualize dependencies between two time series based on their order structure. We use the idea of cross recurrence plots, applied to the local order of the time series. We derive a measure for the coupling strength, which is very robust against observational noise, nonlinear distortion of the amplitude and low-frequency trends. Furthermore we show connections to the instantaneous phase and the determination of phase coupling for two coupled Rössler systems, where this visualization tool is also applicable to the more challenging funnel regime.
Competition between E. coli and Shewanella sp. for electricity generation in air cathode MFC in presence of methylene blue as artificial mediator

Shewanella sp. and E. coli are two types of bacteria which transfer electron in MFC directly and indirectly with aid of an artificial mediator such as: methylene blue (MB). In this study, competition between these bacteria for electricity generation, in pure and binary culture conditions, was studied, considering the effect of MB concentration. For E. coli increasing the MB concentration in the anode chamber from zero to 10 and 25 mol m−3 could enhance the maximum power density from 12.15 ± 1.24 to 22.65 ± 6.59 and 46.14 ± 3.92 mW m−2, respectively. However, further increase of the concentration to 50 mol m−3 decreased the power density to 33.54 ± 9.11 mW m−2. For Shewanella. sp. applying the same range of concentration increase as E. coli (0–50 mol m−3), continuously, diminished the power density from 26.91 ± 1.71 to 14.06 ± 6.84, 12.56 ± 0.90, and 3.01 ± 0.66 mW m−2. The binary culture of these bacteria had an intermediate trend between their pure cultures. These results represented that Shewanella sp. could donate electrons directly and presence of MB, even, lessened the power generation yield. On the contrary, for E. coli the rise of MB concentration to an optimum value facilitated the electron transfer. © 2015 American Institute of Chemical Engineers Environ Prog, 34: 1097–1105, 2015
263-269 Choi KS.pmd

Theileria infections are encountered worldwide, occasionally resulting in serious economic losses for the livestock industry. This study is an epidemiological survey of Theileria infections in Korean indigenous cattle populations in the Republic of Korea (ROK). Blood samples were collected from 100 cattle in April (n=50) (prior to pastureland grazing), and again four months later, in August (n=50) (half of the cattle put out for grazing and the other half kept in housing). All samples were tested for the presence of Theileria infection based on PCR amplification of the small subunit of ribosomal RNA gene. Twenty-two samples across the whole study were verified as positive for Theileria infection by PCR methods. In August, Theileria infection was markedly increased in grazing cattle (16/25 animals, 64%) compared with indoor cattle (4/25 animals, 16%); affected animals exhibited no clinical signs of infection. The red blood cell, hematocrit, and hemoglobin values were significantly lower in Theileriapositive cattle than in Theileria-negative cattle. Phylogenetic analysis demonstrated that the isolates from this study belonged to the T. buffeli species, and were significantly related to Types A, B, C, and E, and were distinct from T. buffeli Type D, which is known to be more pathogenic. These findings indicate that T. buffeli identified in Korean indigenous cattle have a low-to-mild pathogenicity. These results suggest that the T. buffeli infection is relatively higher in the ROK, and the infection rate may increase following grazing. Taken together, T. buffeli infection may not only be seasonally correlated, but also may be affected by management practices such as pastureland grazing.
Mobile-application intervention on physical activity of pregnant women in Iran during the COVID-19 epidemic in 2020

BACKGROUND: Considering the low level of physical activity in pregnant women in the COVID-19 pandemic period, and on the other hand, the benefits of mobile application (mobile app) learning, we decided to conduct a study to determine the impact of educational intervention based on mobile app on physical activity in pregnant women. MATERIALS AND METHODS: The present study was quasi-experimental and examined 93 pregnant women aged 16–20 weeks of gestation. Sampling was done on pregnant women participating in the childbirth preparation classes in Isfahan. We used the validated and reliable questionnaire including perceived benefits, perceived barriers, perceived enjoyment, perceived social support, and Pregnancy Physical Activity Questionnaire. The intervention was based on mobile app, and the content of the application contained 12 main domains such as description of physical activity and benefits and barriers of exercise in the pregnancy, different types of proper pregnancy exercise, planning for exercise, and different types of exercise. Finally, data were analyzed using SPSS20, and the Chi-square test, independent t-test Paired t-test were employed. The significance level was considered to be <0.05. RESULTS: The results showed that, after the intervention based on mobile app, the mean score of perceived benefits and enjoyment were significantly higher than before the intervention in the intervention group. Finally, total mean score of physical activity significantly increased in the intervention group, while the change decreased in the control group. CONCLUSION: The results indicated that the use of mobile app can be used to promote physical activity in pregnant women. Therefore, it is recommended that mobile app education should apply with face-to-face classes in health centers for physical activity in pregnant women in the pandemic situation.
Guided Bone Regeneration with the Use of CGF and Bone Graft in Areas of Bone Resorption in Posterior Maxilla

Introduction: Concentrated Growth Factors (CGF) consisting of a pure biomaterial indicate a high and special regenerative performance on both hard and soft tissues and possess many special properties. Guided bone generation (GBR) is one of the most popular methods for bone augmentation at the exact site of implant placement. Several factors are required however for a successful outcome including wound closure, angiogenesis, space maintenance and clot stabilization. During the GBR procedure, the use of Concentrated Growth factors and stem cells CD34 at the osteotomy site as well as the subsequent immersion of the implant in the Liquid Phase Concentrate Growth Factors (LPCGF) aims at providing excellent and fast healing. Case Report: This case report evaluates and represents the accelerated effect that the use of Concentrated Growth Factors (CGF) and stem cells CD34 combined with Guided Bone Regeneration (GBR) via the simultaneous use of alloplastic bone graft and titanium barrier membrane, can have on maxillary bone augmentation following immediate implant placement. Conclusion: As a result of the use of GBR and Concentrated Growth Factors and stem cells CD34 combined with the simultaneous use of alloplastic bone graft and barrier membrane, accelerated, fast and uneventful regeneration of maxillary bone is succeeded facilitating successful osseointegration with no complications at all.
Accountability and Reporting for Sustainability and Public Value: Challenges in the Public Sector

The present study aims at identifying accountability and reporting answers to the public sector challenges surrounding public value and sustainability. To that end, we take into account the Cohesion Policy Programmes, the EU major investment strategy to understand needs and possible answers in terms of accountability and reporting of the public sector. Particularly, we will consider how a specific policy, the cohesion policy, takes place in practice in the Emilia-Romagna Region case, one of the most advanced European regions in terms of capacity in managing funds received by the EU Cohesion Policy. The Emilia-Romagna Region experience shows the extent to which it planned forms of accountability and reporting that hybridize two of the most recent sustainability developments, integrated reporting and sustainable development goals, as a means to deliver sustainability and public value.
Optical generation of IR-UWB pulse based on weighted sum of modified doublets

We propose a relatively simple optical generation concept for impulse radio ultra wideband (IR-UWB) pulse over fiber transmission using a weighted sum of a modified doublet with its inverted and delayed version. The generated pulses not only fi4ly comply with the FCC spectral mask but also are highly power efficient in the available spectrum. We verified our approach using both simulation and experimental demonstration. The concept has a potential to be integrated with other optical functions on a compact optical chip, making it very suitable for wide UWB deployment for highspeed wireless access at low costfor in-building network applications.
Aquila_stLFR: diploid genome assembly based structural variant calling package for stLFR linked-reads

Abstract Motivation Identifying structural variants (SVs) is critical in health and disease, however, detecting them remains a challenge. Several linked-read sequencing technologies, including 10X Genomics, TELL-Seq and single tube long fragment read (stLFR), have been recently developed as cost-effective approaches to reconstruct multi-megabase haplotypes (phase blocks) from sequence data of a single sample. These technologies provide an optimal sequencing platform to characterize SVs, though few computational algorithms can utilize them. Thus, we developed Aquila_stLFR, an approach that resolves SVs through haplotype-based assembly of stLFR linked-reads. Results Aquila_stLFR first partitions long fragment reads into two haplotype-specific blocks with the assistance of the high-quality reference genome, by taking advantage of the potential phasing ability of the linked-read itself. Each haplotype is then assembled independently, to achieve a complete diploid assembly to finally reconstruct the genome-wide SVs. We benchmarked Aquila_stLFR on a well-studied sample, NA24385, and showed Aquila_stLFR can detect medium to large size deletions (50 bp–10 kb) with high sensitivity and medium-size insertions (50 bp–1 kb) with high specificity. Availability and implementation Source code and documentation are available on https://github.com/maiziex/Aquila_stLFR. Supplementary information Supplementary data are available at Bioinformatics Advances online.
An overview of hydrodesulfurization and hydrodenitrogenation

Hydrodesulfurization (HDS) and hydrodenitrogenation (HDN) of petroleum products and intermediates are reviewed to provide the basis for developing processes to produce gasoline and diesel oil with very low sulfur content. The reactivity, selectivity and inhibition (susceptibility of substrate molecules to inhibitors) in the catalytic process are very important to develop efficient processes. Recent advances in the understanding of active species, supports and supporting methods are also critically reviewed to suggest the design of catalysts with adequate activity to satisfy future regulations on transportation fuels. Details of the structures of the catalysts are not discussed, but the mechanisms of hydrodesulfurization and inhibition are summarized. Catalyst deactivation and reactor design are also briefly reviewed. New approaches to achieve deep hydrodesulfurization are proposed.
Predicting modular functions and neural coding of behavior from a synaptic wiring diagram

How much can connectomes with synaptic resolution help us understand brain function? An optimistic view is that a connectome is a major determinant of brain function and a key substrate for simulating a brain. Here we investigate the explanatory power of connectomics using a wiring diagram reconstructed from a larval zebrafish brainstem. We identify modules of strongly connected neurons that turn out to be specialized for different behavioral functions, the control of eye and body movements. We then build a neural network model using a synaptic weight matrix based on the reconstructed wiring diagram. This leads to predictions that statistically match the neural coding of eye position as observed by calcium imaging. Our work shows the promise of connectome-based brain modeling to yield experimentally testable predictions of neural activity and behavior, as well as mechanistic explanations of low-dimensional neural dynamics, a widely observed phenomenon in nervous systems.
Cognitive and GABAergic protection by hAPPSw,Ind and hTauVLW coexpression: a model of Non-Demented with Alzheimer’s disease Neuropathology

Alzheimer’s disease comprises amyloid-β (Aβ) and hyperphosphorylated Tau (P-Tau) accumulation, imbalanced neuronal activity, aberrant oscillatory rhythms, and cognitive deficits. Non-Demented with Alzheimer’s disease Neuropathology (NDAN) defines a novel clinical entity with Aβ and Tau pathologies, but preserved cognition. The mechanisms underlying such neuroprotection remain undetermined and animal models are currently unavailable for NDAN. We show that J20/VLW mice, accumulating Aβ and P-Tau, exhibit preserved hippocampal rhythmic activity and cognition, altered in J20 and VLW animals. Furthermore, we show that coexistence with Aβ renders a particular P-Tau signature in hippocampal interneurons. The GABAergic septohippocampal pathway, responsible for hippocampal rhythmic activity, is preserved in J20/VLW mice, in contrast to single mutants. Our data highlight J20/VLW mice as a suitable animal model to understand the mechanisms driving cognitive preservation in NDAN and suggest that a differential P-Tau pattern in hippocampal interneurons prevents GABAergic septohippocampal innervation loss and alterations in local field potentials, avoiding cognitive deficits.
Effects of awareness and task relevance on neurocomputational models of mismatch 1 negativity generation 2 Running title : Mechanisms of vMMN : Adaptation or Prediction ?

Effects of awareness and task relevance on neurocomputational models of mismatch 1 negativity generation 2 Running title: Mechanisms of vMMN: Adaptation or Prediction? 3 4 Schlossmacher, Insaa,b, Lucka, Felixc,d, Bruchmann, Maximiliana,b, and Straube, Thomasa,b 5 6 aInstitute of Medical Psychology and Systems Neuroscience, University of Münster, 48149 7 Münster, Germany 8 bOtto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, 9 48149 Münster, Germany 10 cCentrum Wiskunde & Informatica, 1098XG, Amsterdam, The Netherlands 11 dCentre for Medical Image Computing, University College London, WC1E 6BT London, 12 United Kingdom 13 14 15 16 17 18 19 Corresponding author: 20
A Jasmonate-activated MYC 2 – Dof 2 . 1 – MYC 2 Transcriptional Loop 2 Promotes Leaf Senescence in Arabidopsis 3 4

RESEARCH ARTICLE 1 A Jasmonate-activated MYC2–Dof2.1–MYC2 Transcriptional Loop 2 Promotes Leaf Senescence in Arabidopsis 3 4 Mengna Zhuo, Yasuhito Sakuraba, Shuichi Yanagisawa * 5 6 Plant Functional Biotechnology, Biotechnology Research Center, The University of Tokyo, Yayoi 7 1-1-1, Bunkyo-ku, Tokyo 113-8657, Japan 8 * Corresponding author: Shuichi Yanagisawa (asyanagi@mail.ecc.u-tokyo.ac.jp) 9 10 The author responsible for distribution of materials integral to the findings presented in this article in 11 accordance with the policy described in the Instructions for Authors (www.plantcell.org) is: Shuichi 12 Yanagisawa (asyanagi@mail.ecc.u-tokyo.ac.jp) 13 14 Short title: Dof2.1-mediated Promotion of Leaf Senescence 15 One-sentence summary: Dof2.1 and MYC2 form a feed-forward transcriptional loop that enhances 16 jasmonate-induced leaf senescence in Arabidopsis. 17 18 ABSTRACT 19
Iridoid Glucosides with Free Radical Scavenging Properties from Fagraea blumei

Four new iridoid glucosides 1–4, named blumeosides A–D, were isolated from the methanolic stem-bark extract of Fagraea blumei G. DON. (Loganiaceae). They were accompanied by the benzyl-alcohol derivative di-O-methylcrenatin (5) and the flavone C-glucoside swertisin (6). The structures of 1–4 were established by spectroscopic methods, including FAB-MS, and 1H- and 13C-NMR, and by alkaline hydrolysis. Blumeosides A (1) and C (3) are 10-O-(2,5-dihydroxytercphthalo) adoxosidic acid and 10-O-(2-hydroxyterephthalo)adoxosidic acid, respectively. In blumeosides B (4) and D (2), both carboxylic groups of the terephthalic-acid moiety are esterified by adoxosidic-acid units, Blumeosides A–D (1–4) inhibited bleaching of crocin induced by alkoxyl radicals. Blumeosides A (1) and D (2) also demonstrated scavenging properties towards the 2,2-diphenyl-1-picryl-hvdrazvl (CDPPH) radical in TLC autographic and spectrophotometric assays.
The velocity distribution of desorbing molecules: a simulation study

The distribution of velocity and directions of dissolved carbon dioxide, nitrogen and argon molecules escaping from liquid water into the vapour has been analysed. The distributions were found to agree well with those predicted from the thermal flux distribution and not with the recent theory for evaporation proposed by Phillips. Possible reasons for this are discussed.
Fliegenpilzfarbstoffe, VIII1) Die Konstitution der Musca‐aurine

Alle Musca-aurine sind Betalainfarbstoffe 2, denn ihre Hydrolyse liefert Betalaminsaure (4a) und eine der folgenden Aminosauren: Ibotensaure (3a), Stizolobsaure (3b), Glu, α-Aminoadipinsaure (3e), Asp, Glu(NH2), Asp(NH2), Leu, Val, Pro und His. Partialsynthesen bestatigen die Ergebnisse der Konstitutionsermittlung. Colouring Matters from Fly Agaric, VIII1). – Constitution of the Musca-aurins The musca-aurins are betalain-type pigments 2. Hydrolysis yields betalamic acid (4a) together with one of the following amino acids: ibotenic acid (3a), stizolobic acid (3b), Glu, α-amino adipic acid (3e), Asp, Glu(NH2), Asp(NH2), Leu, Val, Pro, and His. Partial synthesis is used to confirm these results.
Title : Frictional stability of porous tuff breccia under subsurface 2 pressure conditions and implications for shallow seismicity

17 Thick layers of unconsolidated sediments are widespread in the Japan island’s surface, 18 and their frictional properties significantly affect the shallow slip behavior during 19 earthquakes. However, laboratory data on the properties of the shallow zone remain 20 limited. We collected tuff breccia samples from deep borehole cores of the Miocene 21 “Green Tuff” formation, a major surface cover, and performed velocity-stepping 22 friction tests on them under in situ stresses of 2 to 20 MPa to assess the velocity23 dependence of frictional strength. The samples exhibit predominantly frictionally stable, 24 velocity-strengthening behavior over the range of normal stress tested, which supports 25 the hypothesis that shallow sediment layers are seismically quiescent. The result is 26 consistent with the low seismicity and attenuation of coseismic slip in the shallow zone 27 observed for the regional earthquakes. Microstructural observations of the postmortem 28 samples through optical and scanning electron microscopies indicate a fabric transition 29 from boundary shear localization to distributed cataclastic flow with increasing normal 30 stress. Our laboratory investigation on depth-variable distribution of friction velocity 31 dependence of a shallow sediment layer would provide further insight into the 32 mechanical role for earthquake rupture dynamics and shallow seismicity. 33 34