Miracle-dz/UniFAR-FTUs huggingface dataset:
Preferences of Underserved Chilean Women on a Mobile Technology Intervention for Cervical Cancer Screening: Qualitative Study

Background In Chile and Latin America, cervical cancer disproportionately affects women of low socioeconomic status. Mobile technology (mobile health, mHealth) may be able to address this disparity by targeting women in underserved populations. However, there is a lack of information regarding barriers to the implementation of mHealth interventions in underserved populations. Objective The objective of this study was to investigate the use of cell phones and text messaging (short message service, SMS) in Latina women from disadvantaged communities to design an mHealth intervention for improving cervical cancer screening rates. Methods We conducted 9 focus groups among women aged 25-64 years to better understand the implementation barriers and perceptions of a text message (SMS)–based intervention designed to improve cervical cancer screening rates. We used the PRECEDE-PROCEED model to categorize identified themes using template analysis. Results Focus group results indicated that older women use mobile phones to receive calls from family and friends but seldom send text messages. Furthermore, they prefer personal contact with their health care providers regarding Papanicolaou (Pap) testing. Younger women, on the other hand, find text messaging easy to use and frequently send texts to family and friends. Importantly, women of all ages mentioned they would like to receive text messages about Pap tests. Factors that facilitate the uptake of the intervention include ease of access to Pap testing, inclusion of family members, and reminder messaging. Potential barriers include cost and the impersonal nature of messaging. Health team members support an mHealth intervention even though they acknowledge the potential barriers to this strategy. Overall, these results support the implementation of an mHealth intervention to increase cervical cancer screening rates. Conclusions This study describes the opinions of women nonadherent to Pap testing on the potential use of mobile technologies for cervical cancer screening. Although the overall acceptance was positive, older women prefer personal contact and phone calls over text messaging. Information surrounding these preferences will aid in the implementation of effective strategies to improve cancer screening in underserved populations.
Genetic association between different criteria to define sexual precocious heifers with growth, carcass, reproductive and feed efficiency indicator traits in Nellore cattle using genomic information

The aim of this study was to estimate genetic parameters for different precocious calving criteria and their relationship with reproductive, growth, carcass and feed efficiency in Nellore cattle using the single-step genomic BLUP. The reproductive traits used were probability of precocious calving (PPC) at 24 (PPC24), 26 (PPC26), 28 (PPC28) and 30 (PPC30) months of age, stayability (STAY) and scrotal circumference at 455 days of age (SC455). Growth traits such as weights at 240 (W240) and 455 (W455) days of age and adult weight (AW) were used. Rib eye area (REA), subcutaneous fat thickness (SFT), rump fat thickness (RFT) and residual feed intake (RFI) were included in the analyses. The estimation of genetic parameters was performed using a bi-trait threshold model including genomic information in a single-step approach. Heritability for PPC traits was moderate to high (0.29-0.56) with highest estimates for PPC24 (0.56) and PPC26 (0.50). Genetic correlation estimates between PPC and STAY weakened as a function of calving age. Correlation with SC455, growth and carcass traits were low (0.25-0.31; -0.22 to 0.04; -0.09 to 0.18, respectively), the same occurs with RFI (-0.09 to 0.08), this suggests independence between female sexual precocity and feed efficiency traits. The results of this study encourage the use of PPC traits in Nellore cattle because the selection for such trait would not have a negative impact on reproductive, growth, carcass and feed efficiency indicator traits. Stayability for sexual precocious heifers (PPC24 and PPC26) must be redefined to avoid incorrectly phenotype assignment.
Honeycomb-like Hard Carbon Derived from Pine Pollen as High-Performance Anode Material for Sodium-Ion Batteries.

Sodium-ion batteries are regarded as one of the most promising energy storage systems, but the choice of anode material is still facing great challenges. Biomass carbon materials were explored for their low cost and wide range of sources. Here, a hard carbon material with a "honeycomb" structure using pine pollen (PP) as a precursor was successfully prepared and applied as an anode. The initial discharge capacity can reach 370 mA h g-1 at a current density of 0.1 A g-1. After cycling 200 times, the reversible capacity also stabled at 203.3 mA h g-1 with the retention rate of 98%. We further studied the sodium storage mechanism by different methods, especially the Na+ diffusivity coefficient ( DNa+) calculated by galvanostatic intermittent titration technique, which was more accurate. Interestingly, the trend of DNa+ coincides with cyclic voltammetry curves. Carbonized PP exhibited excellent electrochemical properties because of its three-dimensional structure and larger layer spacing (∼0.41 nm), which reduces the resistance of sodium ions to intercalation and deintercalation.
Auranofin/Vitamin C: A Novel Drug Combination Targeting Triple-Negative Breast Cancer.

Background Cancer cells from different origins exhibit various basal redox statuses and thus respond differently to intrinsic or extrinsic oxidative stress. These intricate characteristics condition the success of redox-based anticancer therapies that capitalize on the ability of reactive oxygen species to achieve selective and efficient cancer cell killing. Methods Redox biology methods, stable isotope labeling by amino acids in cell culture (SILAC)-based proteomics, and bioinformatics pattern comparisons were used to decipher the underlying mechanisms for differential response of lung and breast cancer cell models to redox-modulating molecule auranofin (AUF) and to combinations of AUF and vitamin C (VC). The in vivo effect of AUF, VC, and two AUF/VC combinations on mice bearing MDA-MB-231 xenografts (n = 5 mice per group) was also evaluated. All statistical tests were two-sided. Results AUF targeted simultaneously the thioredoxin and glutathione antioxidant systems. AUF/VC combinations exerted a synergistic and hydrogen peroxide (H2O2)-mediated cytotoxicity toward MDA-MB-231 cells and other breast cancer cell lines. The anticancer potential of AUF/VC combinations was validated in vivo on MDA-MB-231 xenografts in mice without notable side effects. On day 14 of treatments, mean (SD) tumor volumes for the vehicle-treated control group and the two AUF/VC combination-treated groups (A/V1 and A/V2) were 197.67 (24.28) mm3, 15.66 (10.90) mm3, and 10.23 (7.30)mm3, respectively; adjusted P values of the differences between mean tumor volumes of vehicle vs A/V1 groups and vehicle vs A/V2 groups were both less than . 001. SILAC proteomics, bioinformatics analysis, and functional experiments linked prostaglandin reductase 1 (PTGR1) expression levels with breast cancer cell sensitivity to AUF/VC combinations. Conclusion The combination of AUF and VC, two commonly available drugs, could be efficient against triple-negative breast cancer and potentially other cancers with similar redox properties and PTGR1 expression levels. The redox-based anticancer activity of this combination and the discriminatory potential of PTGR1 expression are worth further assessment in preclinical and clinical studies.
Purification, Characterization and in vitro Evaluation of Polymyxin A From Paenibacillus dendritiformis: An Underexplored Member of the Polymyxin Family

Nosocomial infections caused by antibiotic-resistant Gram-negative pathogens are of grave concern today. Polymyxins are considered as the last resorts of therapy to treat these multi-drug resistant (MDR) bacteria. But their associated nephrotoxicity and neurotoxicity calls for the development of safer polymyxin therapy until novel and less toxic antibiotics are discovered. No other polymyxin molecule except polymyxin B and E (colistin) is explored thoroughly in literature to demonstrate its clinical relevance. In the present study, we have isolated two antimicrobial compounds named P1 and P2 from the soil isolate Paenibacillus dendritiformis strain PV3-16, which we later identified as polymyxin A2 and A1 respectively. We tested their minimum inhibitory concentrations (MICs) against MDR clinical isolates, performed membrane permeabilization assays and determined their interaction with lipopolysaccharide (LPS). Finally, we studied their toxicity against human Leukemic monocyte cell line (THP-1) and embryonic kidney cell line (HEK 293). Both compounds displayed equal efficacy when compared with standard polymyxins. P1 was 2–4 fold more active in most of the clinical strains tested. Moreover, P1 showed higher affinity toward LPS. In cytotoxicity studies, P1 had IC50 value (>1000 μg/ml) similar to colistin against HEK cells but immune cells, i.e., THP-1 cell lines were more sensitive to polymyxins. P1 showed less toxicity in THP-1 cell line than all other polymyxins checked. To sum up, P1 (polymyxin A2) possessed better efficacy than polymyxin B and E and had least toxicity to immune cells. Since polymyxin A was not investigated thoroughly, we performed the comprehensive in vitro assessment of this molecule. Moreover, this is the first report of isolation and characterization of polymyxin A from P. dendritiformis. This compound should be further investigated for its in vivo efficacy and toxicity to develop it as a drug candidate.
Region Label Annotation on Natural Scene Images

Region Label Annotation is an approach to predict relation between semantic concepts and object within image automatically. Claudio Cusano [2], proposed the idea that using the provided annotation information could be effectively exploited to improve image processing procedures. However, they could not handle small region. In this work, a combination of contextual cueing based topological position and neighborhood relationship probability in superpixel domain is presented for seven classes of objects (sky, vegetation, snow, water, ground, street, and sand). Two performance evaluations of the proposed method were conducted using LabelMe dataset. The first evaluation was performed to evaluate the system on superpixel level, the method promisingly could handle small regions such as sand and snow with the accuracy of about 80.08% and 74.21% respectively. The second experiment was performed to evaluate the system on image level, achieving accuracy for two, three and four associated labels for test image by 85.1%, 75.8%, and 74.9% respectively.
Towards Continuous User Recognition by Exploring Physiological Multimodality: An Electrocardiogram (ECG) and Blood Volume Pulse (BVP) Approach

Work on pervasive systems for performing continuous identity recognition has become a major research line due to the more recent developments on wearable and more user-friendly sensors. In this paper we present a multibiometric system based on physiological signals and integrated in a human-computer interaction (HCI) setup, which includes the electrocardiogram (ECG) and blood volume pulse (BVP). Feature extraction was performed on waveform morphology, and k-Nearest Neighbors and Naive-Bayes decision level fusion classifiers were used to perform identification and authentication tests. Furthermore, our approach is based on signal windowing, targeting a near real-time and continuous recognition application scenario. Results show that the BVP signal did not add value to improve the performance of the multimodal approach, but the combined use of windows of different lengths for the ECG modality can yield an increase in the performance. Tests were performed using within- and across- session data, to assess the stability of the signals over time, and the generalization ability of the classifiers. Rank-1 Error of Identification (EID) values of approximately 2% and 8% were obtained respectively in withinand across-session identification tests while, in authentication, Equal Error Rate (EER) values of approximately 4% and 13% were achieved.
Venovo venous stent in the treatment of non-thrombotic or post-thrombotic iliac vein lesions - short-term results from the Arnsberg venous registry.

BACKGROUND We sought to determine the patency and clinical symptom relief of the Venovo venous stent in the endovascular treatment of non-thrombotic (NIVL) or post-thrombotic venous obstruction (PTO) of the iliofemoral track over a period of 6 months. PATIENTS AND METHODS A total of 80 patients (45 female, mean age 57 years) treated in 2016 and 2017 were included in the Arnsberg venous registry. Clinical improvement was determined by the revised venous clinical severity score (rVCSS) as well as the clinical, etiologic, anatomic and pathophysiologic (CEAP) score. Primary and secondary stent patency was evaluated using duplex ultrasound. RESULTS Overall 6-months patency rates were 98 % for primary and 100 % for secondary patency. For NIVL primary patency was 97 %, whereas for PTO primary patency was 96 %. Early stent re-occlusion occurred in 3 patients within 34, 59 and 156 days after intervention. Two of these patients were successfully treated by endovascular mechanical thrombectomy and stent in stent implantation. Clinical improvement with a gain of ≥ 2 rVCSS levels was observed in 51 %. CEAP scores decreased from 4.3 to 2.7. CONCLUSIONS In this first time report the novel Venovo venous stent showed adequate patency rates associated with reasonable clinical improvement and low device-related complications throughout a 6-months-follow-up in both NIVL and PTO.
The guanine nucleotide exchange factor Vav3 modulates oligodendrocyte precursor differentiation and supports remyelination in white matter lesions

The tightly controlled processes of myelination and remyelination require the participation of the cytoskeleton. The reorganization of the cytoskeleton is controlled by small GTPases of the RhoA family. Here, we report that Vav3, a Rho GTPase regulating guanine nucleotide exchange factor (GEF) is involved in oligodendrocyte maturation, myelination and remyelination. When Vav3 was eliminated by genetic recombination, oligodendrocyte precursor cell (OPC) differentiation toward mature oligodendrocytes was accelerated. In contrast, Vav3‐deficient oligodendrocytes displayed a reduced capacity to myelinate synthetic microfibers in vitro. Furthermore, remyelination was impaired in Vav3 knockout cerebellar slice cultures that were demyelinated by the addition of lysolecithin. In agreement with these observations, remyelination was compromised when the cuprizone model of myelin lesion was performed in Vav3‐deficient mice. When Vav3‐deficient oligodendrocytes were examined with Förster resonance energy transfer (FRET)‐based biosensors, an altered activation profile of RhoA GTPases was revealed on the cellular level, which could be responsible for an impaired remyelination. Taken together, this study highlights Vav3 as a novel regulator of oligodendrocyte maturation and remyelination, suggesting that manipulation of the Vav3‐dependent signaling pathway could help to improve myelin repair.
Improving I/O Performance of Large-Page Flash Storage Systems Using Subpage-Parallel Reads

Handling small read requests is important on large-page flash storage systems because small reads tend to waste the read bandwidth. We present a system level solution that avoids wasting the read bandwidth based on a new page read operation, called the subpage-parallel read (SPread). SPread achieves an optimal latency for a small read request by reading requested subpages only. By improving the read performance of applications as well as garbage collection, SPread improves the overall I/O performance. Experimental results show that an SPread-aware FTL can improve the IOPS and read latency by up to 122% and 56%, respectively.
Dual-band Planner Slot antenna loaded with Split Ring Resonators for WLAN/Wi-Max Applications

Microstrip fed dual band planner slot antenna using split ring resonators (SRR) is proposed. Split ring resonator acting as a loading element introduces dual bands, which can be controlled by altering the number of rings and the space between them. Wideband is achieved at both resonating frequencies by using the circular shape of SRR and slot antenna. With satisfactory gain and radiation pattern the proposed antenna is suitable for lower range of WLAN and higher range of Wi-MAX and other broadband services. The design and optimization is carried out using CST Microwave Studio. Nicolson-Ross-Weir (NRW) approach is used to verify the Double Negative properties of this structure.
Safety-critical Geometric Control Design with Application to Aerial Transportation

Safety constraint are ubiquitous in many robotic applications. For instance, aerial robots such as quadrotors or hexcoptors need to realize a fast collision-free flight, and bipedal robots have to choose their discrete footholds properly to gain the desired friction and pressure contact forces. In this thesis, we address the safety critical control problem for fully-actuated and under-actuated mechanical systems. Since many mechanical systems evolve on nonlinear manifolds, we extend the concept of Control Barrier Function to a new concept called geometric Control Barrier Function which is specifically designed to handle safety constraints on manifolds. This type of Control Barrier Function stems from geometric control techniques and has a coordinate free and compact representation. In a similar fashion, we also extend the concept of Control Lyapunov Function to the concept of geometric Control Lyapunov Function to realize tracking on the manifolds. Based on these new geometric versions of CLF and CBF, we propose a general control design method for fully-actuated systems with both state and input constraints. In this CBF-CLF-QP control design, the control input is computed based on a state-dependent Quadratic Programming (QP) where the safety constraints are strictly enforced using geometric CBF but the tracking constraint is imposed on using relaxation. Through this type of relaxation, the controller could still keep the system state safe even in the cases when the reference is unsafe during some time period. For a single quadrotor, we propose the concept of augmented Control Barrier Function specifically to let it avoid external obstacles. Using this augmented CBF, we could still utilize the idea of CBF-CLF-QP controller in a sequential QP control design framework to let this quadrotor remain safe during the flight. In meantime, we also apply the geometric control techniques to the aerial transportation problem where a payload is carried by multiple quadrotors through cable suspension. This type of transportation method allows multiple quadrotors to share the payload weight, but introduces internal safety constraints at the same time. By employing both linear and nonlinear techniques, we are able to carry the payload pose to follow a pre-defined trajectory.
Kinematical, Structural and Mechanical Adaptations to Desiccation in Poikilohydric Ramonda myconi (Gesneriaceae)

Resurrection plants have fascinated scientists since centuries as they can fully recover from cellular water contents below 10%, concomitantly showing remarkable leaf folding motions. While physiological adaptations have been meticulously investigated, the understanding of structural and mechanical adaptations of this phenomenon is scarce. Using imaging and bending techniques during dehydration-rehydration experiments, morphological, anatomical, and biomechanical properties of desiccation-tolerant Ramonda myconi are examined, and selected structural adaptations are compared to those of homoiohydrous Monophyllaea horsfieldii (both Gesneriaceae). At low water availability, intact and cut-off R. myconi leaves undergo considerable morphological alterations, which are fully and repeatedly reversible upon rehydration. Furthermore, their petioles show a triphasic mechanical behavior having a turgor-based structural stability at high (Phase 1), a flexible mechanically state at intermediate (Phase 2) and a material-based stability at low water contents (Phase 3). Lastly, manipulation experiments with cut-off plant parts revealed that both the shape alterations of individual structures, as well as, the general leaf kinematics largely rely on passive swelling and shrinking processes. Taken together, R. myconi possesses structural and mechanical adaptations to desiccation (in addition to physiological adaptations), which may mainly be passively driven by its water status influenced by the water fluctuations in its surroundings.
Sleep patterns and nocturnal cardiac autonomic activity in female athletes are affected by the timing of exercise and match location

ABSTRACT The aim of the current study was to analyze the influence of the timing of training and matches, and match location, on sleep pattern and nocturnal cardiac autonomic activity in female soccer players. A total of 17 female soccer players (age: 21.6 ± 2.3 years; mean ± SD) wore wrist actigraph units and heart rate (HR) monitors during night-sleep throughout 18 night-training days (NTD), 18 resting days (RD), and 6 match-days (MD; 3 away-matches [AM] and 3 home-matches [HM]) of the competitive period. Training load was quantified by session rating of perceived exertion (sRPE), heart rate (HR), training impulse (TRIMP), and subjective well-being. In NTD, sleep onset time and total sleep time were significantly impaired compared to MD (+ 1:47 [0:48; 1:55] hours and −1:35 [−1:42; −0:57] hours, respectively; p< 0.001; mean difference ± 95% confidence interval [CI]) and RD (+ 1:31 [0:52; 1:49] hours and −1:26 [−1:28; −0:55] hours, respectively; p< 0.001). In AM, sleep onset time was delayed compared to HM (+ 0:36 [0:12; 0:44] hours; p< 0.001). Sleep latency was higher in NTD compared to RD (+ 4 [2; 5] min; p< 0.001), as well as after AM compared to HM (+ 5 [1; 7] min; p< 0.001). HR during sleep was significantly increased after NTD and MD compared to RD (+ 4 [1; 5] b.p.m and + 3 [1; 4] b.p.m, respectively; p< 0.001). Furthermore, HR variability decreased after NTD and MD compared to RD (e.g., lnRMSSD, −0.09 [−0.18; −0.08] ln[ms] and −0.17 [−0.27; −0.11] ln[ms], respectively; p< 0.001). Overall, the time of day for soccer practice (i.e., training at night) and match location (i.e., away matches) may cause disruption in sleep patterns and/or in autonomic cardiac activity in female soccer players. Additionally, playing official matches during the day and training at night may affect nocturnal cardiac autonomic activity by decreasing vagal-related modulation and increasing HR during sleep.