Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of Mechanical Aortic Prostheses in hospital stay and anticoagulation related complications

Objective: Use of mechanical valves requires long-term anticoagulation, which carries additional risks of bleeding and thrombosis. The aim of the study was to investigate the impact of anticoagulation on length of postoperative stay and the incidence of anticoagulation-related complications. Methods: A multicentre study of prospectively collected data, including all patients below 65 years of age undergoing aortic valve replacement (± concomitant non-valvular procedures) was performed. Exclusion criteria included preoperative atrial fibrillation and other indications for anticoagulation, previous cardiac surgery, emergency operations of hospital stay and anticoagulation-related complications within 6 weeks of discharge. Results: A total of 1973 patients were included over a 5-year period from 5 centres in the UK. Mean patient age was 59 years (range 17-65 years). Mechanical valves were implanted in 52% of patients. The use of mechanical prostheses was associated with significantly prolonged postoperative stay (median of 7 vs. 6 days with bioprosthesis, p < 0.001) being an independent predictor of prolonged postoperative stay (> 8 days; OR 1.55, 95% CI 1.27-1.90, p < 0.001). On subanalysis, 1.4% of patients with mechanical prosthesis required readmission for anticoagulation-related complications within 6 weeks of discharge (including late tamponade). An additional 2% required repeated hospital attendance for INR stabilisation. Conclusion: Use of mechanical valves in patients below 65 years of age is associated with both increased hospital stay and anticoagulation-related complications compared to bioprosthesis. The clinical and health economic implications of prosthesis choice should be considered by both the heart team and patient.
Molecular and functional characterization of the role of the histone methyltransferase SETDB1 in malignant melanoma

Malignant melanoma is the most deadly skin cancer. Clinical studies reported a dramatic increase in the incidence of melanoma over the past few years. A very distinctive feature of melanoma is its high degree of heterogeneity and cellular plasticity. Within the tumor there are different genetically defined subpopulations of melanoma cells, which is one of the reasons for the low efficacy of targeted therapies. Furthermore, most melanomas quickly develop a resistance to these therapies, causing tumor relapse. For all these reasons, gaining an understanding of the molecular and cellular mechanisms driving melanoma progression will be important for developing potent therapeutic approaches. So far, some key regulatory pathways normally activated in melanoma have been well defined, and these pathways are mainly driven by activation of oncogenes like BRAF and NRAS, with a considerable relevance for clinical practice. However, the identification of novel key regulators and pathways is still a challenge and will help to better understand melanoma development and to open up new possibilities to treat therapy resistant tumors. Recent studies and work previously conducted in our laboratory reported that the histone methyltransferase SETDB1 plays a major role in melanoma pathogenesis. It has been observed that SETDB1 expression, which correlates with its amplification state in melanoma, is also associated with melanoma progression. However, the role of SETDB1 and its mode of action in melanoma are still unclear. The aim of this project is to clarify the role of SETDB1 in melanoma, through the identification and functional characterization of SETDB1-mediated molecular mechanisms. Here, I report that SETDB1 expression caused deep changes in melanoma transcriptome resulting in the deregulation of pro- and anti-tumorigenic factors. Specifically, SETDB1 induced THBS1 upregulation and suppressed DCT expression. SETDB1 functions are dependent on its catalytic SET domain. During melanoma progression, SETDB1 promoted important epigenetic alterations such as changing the genomic distribution of H3K9me3 and H3K4me1 marks. These histone 2 modifications impacted the transcription of SETDB1 downstream targets. I could show that melanoma cells were sensitive to treatment with the SETDB1-inhibitor mithramycin A. Mithramycin treatment suppressed SETDB1 expression and tumorigenic properties of melanoma cells. Combinatorial treatment with mithramycin and MAPK inhibitors showed enhanced anti-tumor effects. Taken together, the findings presented here highlight the crucial functional and mechanistic role of SETDB1 in melanoma. SETDB1 could be considered as a potential future target for the treatment of melanoma.
Effects of agonistic anti-CD137 antibody on chikungunya virus infection and B cell responses

ix Chapter 1: Introduction 1 Chapter 2: Clearance of Chikungunya virus infection in lymphoid tissues 15 is promoted by treatment with an agonistic anti-CD137 antibody Chapter 3: An agonistic anti-CD137 antibody disrupts lymphoid follicle 46 structure and T cell-dependent antibody responses Chapter 4: Conclusions and Future Directions 106
The crystal structures of the synthetic zeolites (Cs, K)-ZK5 and (Cs, D)-ZK5 determined from neutron powder diffraction data

The structure of a dehydrated ZK5 zeolite with the calculated composition Cs9 7K13. 0SÌ73. 2AI22.8O192 w a s refined using data collected on a high resolution neutron powder diffractometer at 294Κ (a = 18.671(1)Â) and at 493 Κ (a = 18.660(1)Â) using a combination of Rietveld and Fourier techniques. The structures of a deuterated ZK5 with the composition D 1 7 5Cs3 9Ko. 8SÌ73. 8Al22.20i92 (α = 18.673(1) Â), and Cs-exchanged Z K 5 (D1 3 0Cs6 0K2.7SÌ74 3Α12ι.7θΐ92,α = 18.688(1)Â) were also refined at 294K. There is no evidence for Si/Al ordering (space group Im3m). Cs occupies the flat 8-ring site « C s — 0 ) = 3.3 Â), while Κ prefers the puckered 8-ring site « Κ — 0 > = 2. 9Â). There are significant distortions of pore openings upon extraction of the cations. The flat 8-ring is distorted elliptically. Both the ion-exchange properties of ZK 5 and the positions of Cs and Κ can be explained in terms of the refined structure. The Cs preference for the flat 8-ring site sets an upper limit of 12 atoms/unit cell to its exchange into ZK5. The proximity of the flat and puckered 8-ring sites (5.8 Â) causes the Cs atom either to move towards the α cage if Κ is present or to relax toward the y cage if Κ is extracted. ' Present address : Research School of Chemistry, Australian National University, Canberra, ACT 2600, Australia 2 Contribution number 3200 3 Work performed at Brookhaven National Laboratory. Supported by the Division of Materials Sciences. US Department of Energy, under Contract DE-AC02-76CH00016 176 John Β. Parise et al.: The structure of ZK5 from neutron powder diffraction data
Inductive Approach Used in Teaching Speaking Skill: A Content Analysis

This study aims to determine the feasibility of implementing an inductive approach in teaching speaking skills. The qualitative descriptive was used in this study by using content analysis technique. The technique of obtaining data used documentation. The data were analyzed by coding, display, and verification. The data analysis was carried out in depth by using some theories related to the inductive approach in teaching speaking skills. The results of the study indicate the interrelated of the implementation and responses of the students in using this approach. The results show that the inductive approach is very helpful for students in learning to speak English because it is based on the examples given and they have learnt to find patterns in English speaking. By seeing the examples, they also learn how to imitate the way how people say in English and they are actively involved in the teaching and learning process. Furthermore, it is suggested that inductive approach can be used in speaking class.
The Role of Mental Well-Being and Perceived Parental Supportiveness in Adolescents’ Problematic Internet Use: Moderation Analysis

Background Given the growing number of adolescents exhibiting problematic internet use (PIU) and experiencing its harmful consequences, it is important to examine the factors associated with PIU. Existing research has identified perceived parental supportiveness and adolescents’ subjective mental well-being as strong predictors of PIU. However, it is unknown how these factors work together in shaping adolescents’ engagement in PIU. Objective This paper aimed to examine the role played by adolescents’ perception of parental supportiveness in conjunction with their subjective mental well-being in shaping their PIU. Methods The study analyzed one of the Technology & Adolescent Mental Wellness (TAM) data sets that were collected from a nationally representative cross-sectional sample. Adolescents self-reported their internet use behavior, perceived parental supportiveness, and subjective mental well-being through an online research panel survey. Hierarchical linear regression analysis with an interaction term was performed. Results A total of 4592 adolescents, aged 12 to 17 years, completed the survey. Adolescents reported a mean age of 14.61 (SD 1.68) and were 46.4% (2130/4592) female and 66.9% (3370/4592) White. Findings revealed that, controlling for adolescents’ demographics and social media use, higher levels of perceived parental supportiveness (β=–.285, P<.001) and higher levels of subjective mental well-being (β=–.079, P<.001) were associated with a lower likelihood of adolescent PIU. The moderation analysis showed that the negative association between perceived parental supportiveness and PIU was stronger when adolescents reported high (vs low) levels of mental well-being (β=–.191, P<.001). Conclusions This study shows that perceived parental supportiveness was a stronger protective factor than adolescents’ mental well-being against PIU. The protective power of perceived parental supportiveness against PIU was strongest when adolescents had high mental well-being. The highest risk of PIU occurred when adolescents’ mental well-being was high, but parents were perceived as unsupportive. Our findings suggest that parental supportiveness should be targeted as part of PIU prevention efforts.
Structural Determination of Copolymers from the Cross-catalyzed Reactions of Phenol-formaldehyde and Polymeric Methylenediphenyl Diisocyanate

This work reports the elucidation of the structure of a copolymer generated by the crosscatalyzed reactions of PF and pMDI prepolymers. The electronic behavior of phenolic monomers as perturbed by alkali metal hydroxides in an aqueous environment was studied with 1H and 13C NMR. Changes in electronic structure and thus reactivity were related to solvated ionic radius, solvent dielectric constant, and their effect on ion generated electric field strength. NMR chemical shifts were used to predict order of reactivity for phenolic model compounds with phenyl isocyanate with good success. As predicted, 2-HMP hydroxymethyl groups were more reactive than 4-HMP in forming urethane bonds under neutral conditions and 2-HMP hydroxymethyl groups were more reactive than 4-HMP in forming urethane bonds under alkaline conditions. The structure of the reaction products of phenol, benzyl alcohol, 2-HMP, and 4-HMP with phenyl isocyanate were studied using 1H and 13C NMR under neutral organic and aqueous alkaline conditions. Reactions in THF-d8 under neutral conditions, without catalyst, were relatively slow, resulting in residual monomer and the precipitation of 1,3diphenyl urea from the carbamic acid reaction. The reactions of phenol, 2-HMP, and 4HMP in the presence of TEA catalyst favored the formation of phenyl urethanes (PU). Reactions with benzyl alcohol, 2-HMP, and 4-HMP in the presence of DBTL catalyst favored the formation of benzyl urethanes (BU). Reactions of 2-HMP and 4-HMP led to formation of benzylphenyldiurethane (BPDU). DBTL catalysts favored formation of BDPU strictly by a benzyl urethane pathway, while TEA favored its formation mostly via phenyl urethane, although some BU was also present. Under aqueous alkaline conditions, 2-HMP was more reactive than 4-HMP, exhibiting an enhanced reactivity that was attributed to intramolecular hydrogen bonding and a resulting resonance stabilization of the phenolic aromatic ring. ATR-FTIR spectroscopic studies generated real time structural information for model compound reactions of the cross-catalyzed system, differentiating among reaction peaks
Approximated logarithmic maps on Riemannian manifolds and their applications

Recently, optimization problems on Riemannian manifolds involving geodesic distances have been attracting considerable research interest. To compute geodesic distances and their Riemannian gradients, we can use logarithmic maps. However, the computational cost of logarithmic maps on Riemannian manifolds is generally higher than that on the Euclidean space. To overcome this computational issue, we propose approximated logarithmic maps. We prove that the deﬁnition is closely related to the inverse retractions. Numerical experiments for computing the Riemannian center of mass show that the proposed approximation signiﬁ-cantly reduces the computational time while maintaining appropriate precision if the data diameter is suﬃciently small.
PENGUKURAN KUALITAS WEBSITE RUMAH BATIK ANDALAN METODE WEBQUAL 4.0 DAN IMPORTANCE PERFORMANCE ANALYSIS

Rumah Batik Andalan is a shop that produces Malay batik with the name of the mainstay batik home website. The website has never been evaluated on the quality of the website so there is no known level of website quality on visitor satisfaction. Webqual 4.0 method website problems on the Usability dimension regarding unattractive appearance, the Information Quality dimension is not updated in batik motifs, the Interaction Quality dimension does not have a sale and purchase transaction feature. The purpose of this study was to analyze website quality using the Webqual 4.0 method and Importance Performance Analysis (IPA). This research uses a quantitative approach by distributing questionnaires to visitors. The tools used to process data from questionnaires on WebQual and IPA are SPSS 22. The results of the analysis of the suitability level are still below 100% and the attributes are low with a value of 48%, which is quite detailed and safe information when transacting. all indicators, this shows that the quality of the website otherwise can not meet the wishes of users. While the results of the IPA analysis show that the priority indicators for improvement on the website are an attractive appearance, provide detailed information, and are safe when making transactions. The results of the calculation of the level of user satisfaction from the Customer Satification Index (CSI) on the Rumah Batik Andalan website obtained a value of 65%, this shows that the overall website performance was quite satisfied
Função logística e algoritmos de otimização para a modelagem da distribuição diamétrica em um fragmento de Cerrado / Logistic function and optimization algorithms for diametric distribution modeling in a typical Cerrado

This work aimed to evaluate the performance of different optimization algorithms to diametric distribution modelling of stems in a typical cerrado (tree savanna proper) fragment, using the two parameters Logistics function. Data collection was carried out in eight plots of 600 m2 randomly distributed in a typical cerrado fragment, located in the district of Desembargador Otoni, municipality of Diamantina-MG. The data were grouped into biometric classes with regular intervals of 2 cm in diameter. Three optimization algorithms were tested (NM: Nelder-Mead; BFGS: Broyden-Fletcher-Goldfarb-Shanno and SANN: Subsequent Artificial Neural Network). All adjustments made showed adherence by the Kolmogorov-Smirnov test. Predictive differences of the typical cerrado fragment, with emphasis on the BFGS algorithm, which showed slightly better predictive quality than the others.
Adaptive force/ position control for dual-arm system based on neural network radial basis function without using a force sensor

The paper has developed an adaptive algorithm using neural network for controlling dual-arm robotic system in stable holding a rectangle object and moving it to track the desired trajectories. Firstly, an overall dynamic of the system including the dual-arm robot and the object is derived based on Euler-Lagrangian principle. Then based on the dynamics, a controller has proposed to achieve the desired trajectories of the holding object. A radial basis neural network has been applied to compensate uncertainties of system parameters. The adaptive learning algorithm has been derived owning to Lyapunov stability principle to guarantee asymptotical convergence of the closed loop system. Besides, force control at contact point is implemented without the measurements of forces and moments at contact points. Finally, simulation work on Matlab has been carried out to confirm the accuracy and the effectiveness of the proposed controller.
An investigation into gas transfer from bubbles into water

The current design of mass transfer systems for gas bubbles absorbing into a liquid is mainly restricted to the use of empirical relations which involve a high level of uncertainty. This is due to a lack of understanding of the interactions of gas bubbles and the liquid phase, and of how this affects the mass transfer. This work set out to enhance our understanding of the mass transfer of CO2 from concentrated sources such as flue gases into the aqueous phase, for use in applications such as micro-algal biomass cultivation systems. Bubble characteristics were observed using high speed imaging for single bubbles and optical fibre sensors for bubble swarms. These techniques were combined with gas chromatographic analysis of input and output gas samples to obtain a mass balance and measurements of the mass transfer. The mass transfer rate in bubble swarms was observed to be greater than that of single bubbles. For larger bubble sizes, this is partly due to the increased bubble rise velocity in bubble swarms. This was observed to increase, in part, due to the reduced drag a bubble experiences when it follows in the wake of a preceding bubble. Smaller bubbles within bubble swarms did not experience the same inhibition of mass transfer as was evident for single bubbles. This inhibition of the gas-liquid interface of single bubbles is due to the accumulation of surfactants which attach to the bubble surface, transforming the properties of the gas-liquid interface and reducing the mass transfer rate. The reduced mass transfer in single bubbles compared to bubble swarms was more apparent at lower input concentrations of CO2. This suggested a possible reduction in the internal circulation within the bubble, due to surfactant accumulation which reduces the gas-side resistance to mass transfer and is more apparent at a dilute gas concentration. Finally the experimental results from this work were compared with a simple finite difference model which analysed the mass balance of a rising bubble. The mass transfer coeffcient of single bubbles with a mobile gas-liquid interface could be approximated by the penetration theory of Higbie (1935), while with sufficient surfactant accumulation to transform the bubble surface to an immobile gas-liquid interface the rigid particle theory by Frossling (1938) provided a good approximation. In bubble swarms, however, the theory for a mobile gas-liquid interface based on Higbie (1935) provided a reasonable approximation throughout the range of bubble sizes studied in this work.
Leadership Styles and Organizational Commitment with Mediation of Organizational Citizenship Behavior among Bahraini Managers

This study explores the role of organizational citizenship behavior as a mediating variable to the relationship between leadership styles and organizational commitment among Bahraini managers. Organizational citizenship behavior was in debate regards it is positive and negative consequences through the literature, most of the studies support the conclusion of organizational commitment that leads to organizational citizenship behavior, other studies support the opposite. However, the mediating relationship of organizational citizenship behaviors between leadership styles and organizational commitment is not developed by previous studies. Therefore, the use of the mediating variable gives more insight into the relationship between the dependent and independent variables and contributes to the clarity of conclusions. This study found that leadership presents a positive significant relationship with organizational commitment and organizational citizenship behavior, and organizational citizenship behavior positively and significantly affects organizational commitment and partially mediates the relationship between the two variables.
Effects of radiation therapy on the dislocation resistance of root canal sealers applied to dentin and the sealer-dentin interface: a pilot study

Objectives This study evaluated and compared the effects of radiation therapy on the dislocation resistance of AH Plus and BioRoot RCS applied to dentin and the sealer-dentin interface. Materials and Methods Thirty single-rooted teeth were randomly assigned to 2 groups (n = 15 each): AH Plus (Dentsply DeTrey) and BioRoot RCS (Septodont). Each group was subdivided into control and experimental groups. The experimental group was subjected to a total radiation dose of 60 Gy. The root canals of all samples were cleaned, shaped, and obturated using the single-cone technique. Dentin slices (1 mm) were sectioned from each root third for the push-out test and scanning electron microscopy (SEM) was done to examine the sealer-dentin interface. The failure mode was determined using stereomicroscopy. Bond strength data were analyzed by the independent t-test, 1-way analysis of variance, and the Tukey post hoc test (α = 0.05). Results Significantly lower bond strength was observed in irradiated teeth than non-irradiated teeth in the AH Plus group (p < 0.05). The BioRoot RCS group showed no significant reduction in bond strength after irradiation (p > 0.05) and showed a higher post-irradiation bond strength (209.92 ± 172.26 MPa) than the AH Plus group. SEM revealed slightly larger gap-containing regions in irradiated specimens from both groups. Conclusions The dislocation resistance of BioRoot RCS was not significantly changed by irradiation and was higher than that of AH Plus. BioRoot RCS may be the sealer of choice for root canal treatment in patients undergoing radiation therapy.
Comparative Study on Various Methods for Measuring Engine Particulate Matter Emissions

Studies have shown that there are a significant number of chemical species present in engine exhaust particulate matter emissions. Additionally, the majority of current world-wide regulatory methods for measuring engine particulate emissions are gravimetrically based. As modern engines considerably reduce particulate mass emissions, these methods become less stable and begin to display higher levels of measurement uncertainty. In this study, a characterization of mass emissions from three heavy-duty diesel engines, with a range of particulate emission levels, was made in order to gain a better understanding of the variability and uncertainty associated with common mass measurement methods, as well as how well these methods compare with each other. Two gravimetric mass measurement methods and a reconstructed mass method were analyzed as part of the present study. The results have shown that each of the mass measurement methods analyzed compare well at higher emission levels, but show significant disparity at the ultra-low emission levels commonly seen from modern diesel engines. Additionally, at ultra-low emissions, the uncertainty in the measurement becomes large, thus reducing confidence in the accuracy of the measurement. Based upon these findings, it would be difficult to justify a comparison between any two gravimetric measurement methods and it may be more appropriate to perform a reconstruction of the particulate mass due to a lower susceptibility to measurement error.