Miracle-dz/UniFAR-FTUs huggingface dataset:
Differences in Menstruation-Related Symptoms of University Students Depending on Their Living Status in Japan

Mothers and family members of young female students play important roles for guiding their self-care strategies for menstruation-related symptoms; which often affect their daily life and academic life. The aim of this study is to clarify the differences in menstruation-related symptoms before and during menstruation in university students living alone and university students living with their family in Japan. We conducted a cross-sectional online survey to assess menstruation-related symptoms before and during menstruation using the menstrual distress questionnaire (MDQ). Among 135 students; the proportion of students living alone was 60.7% and the proportion of students living with their family was 39.3%. Before menstruation; the MDQ total score and the scores for negative affect and behavior change were significantly higher in students living alone than in students living with their family. During menstruation; scores for negative affect and impaired concentration were also significantly higher in students living alone. In addition; before menstruation; scores for an increase in appetite and craving for sweets were significantly higher in students living alone. Thus; living alone affected the psychological aspects of menstruation-related symptoms in young women. The results suggest that university students who live alone should be aware of the importance of talking about their menstruation problems with family members and seeking their advice
How to Develop Moral Skills in Sport by Using the Corruption Heritage?

This paper examines how the corruption heritage of South-Eastern European sport can be used as content for educational strategies designed to improve the ethics and integrity in today’s sport. Hidden or dark history is useful when considering an education for a sustainable development approach to improving athletes’ moral skills. In education, examining mistakes can be a useful tool for preventing their recurrence as they provide examples for study and content for evidence-based learning. At the same time, it is a useful process, aiming to develop critical thinking and the decision-making skills in the area of sports. This paper provides examples on how narratives can be used in the field of sport moral education and what patterns reflecting the lack of integrity in sport can be identified. Because it has perpetuated and altered the image and principles of sports competition, diminishing trust in sport sustainability, it is important to identify how this effect can be approached from the perspective of the education for sustainable development (ESD), as applied to the area of sports. However, it is essential that sports integrity be valued by society and that all sports actors (athletes, coaches, officials) promote ethics and fair play.
Reconstruction and Exploratory Analysis of mTORC1 Signaling Pathway and Its Applications to Various Diseases Using Network-Based Approach

Mammalian target of rapamycin (mTOR) is a serine-threonine kinase member of the cellular phosphatidylinositol 3-kinase (PI3K) pathway, which is involved in multiple biological functions by transcriptional and translational control. mTOR is a downstream mediator in the PI3K/Akt signaling pathway and plays a critical role in cell survival. In cancer, this pathway can be activated by membrane receptors, including the HER (or ErbB) family of growth factor receptors, the insulin-like growth factor receptor, and the estrogen receptor. In the present work, we congregated an electronic network of mTORC1 built on an assembly of data using natural language processing, consisting of 470 edges (activations/interactions and/or inhibitions) and 206 nodes representing genes/proteins, using the Cytoscape 3.6. 0 editor and its plugins for analysis. The experimental design included the extraction of gene expression data related to five distinct types of cancers, namely, pancreatic ductal adenocarcinoma, hepatic cirrhosis, cervical cancer, glioblastoma, and anaplastic thyroid cancer from Gene Expression Omnibus (NCBI GEO) followed by pre-processing and normalization of the data using R & Bioconductor. ExprEssence plugin was used for network condensation to identify differentially expressed genes across the gene expression samples. Gene Ontology (GO) analysis was performed to find out the over-represented GO terms in the network. In addition, pathway enrichment and functional module analysis of the protein-protein interaction (PPI) network were also conducted. Our results indicated NOTCH1, NOTCH3, FLCN, SOD1, SOD2, NF1, and TLR4 as upregulated proteins in different cancer types highlighting their role in cancer progression. The MCODE analysis identified gene clusters for each cancer type with MYC, PCNA, PARP1, IDH1, FGF10, PTEN, and CCND1 as hub genes with high connectivity. MYC for cervical cancer, IDH1 for hepatic cirrhosis, MGMT for glioblastoma and CCND1 for anaplastic thyroid cancer were identified as genes with prognostic importance using survival analysis.
Significantly Enhanced Crystallization of Poly(ethylene succinate-co-1,2-propylene succinate) by Cellulose Nanocrystals as an Efficient Nucleating Agent

Poly(ethylene succinate-co-1,2-propylene succinate) (PEPS) is a novel aliphatic biodegradable polyester with good mechanical properties. Due to the presence of methyl as a side group, the crystallization rate of PEPS is remarkably slower than that of the poly(ethylene succinate) homopolymer. To promote the potential application of PEPS, the effect of cellulose nanocrystals (CNC) on the crystallization behavior, crystalline morphology, and crystal structure of PEPS was investigated in this research with the aim of increasing the crystallization rate. CNC enhanced both the melt crystallization behavior of PEPS during the cooling process and the overall crystallization rate during the isothermal crystallization process. The crystallization rate of PEPS became faster with an increase in CNC content. The crystalline morphology study directly confirmed the heterogeneous nucleating agent role of CNC. The crystal structure of PEPS remained unchanged in the composites. On the basis of the interfacial energy, the nucleation mechanism of PEPS in the composites was further discussed by taking into consideration the induction of CNC.
Optimization Based Control Strategy for Energy Efficient Decelerations in an Automobile Cruise Controller

With global warming and increased uncertainty about future vehicle fuel supply, the need for fuel efficient vehicles is growing. In this Master Thesis, design and implementation of a control strategy for fuel efficient deceleration is presented. The resulting deceleration controller, implemented in Embedded Matlab and Simulink, provides autonomous deceleration functionality to a vehicle cruise controller. Deceleration patterns are produced through online optimization of a cost function comprising fuel consumption and time loss. The cost function is calculated based on navigation information for the predicted driving path, which is also used to detect upcoming deceleration situations. The potential for fuel savings is estimated through simulation, and experiences from tentative driving tests are presented. The optimization approach proves to yield flexibility in balancing fuel savings versus time loss, while being fast enough to be run online as a prototype function in a test vehicle. The deceleration optimizer function could either be used in its current form in future cruise controllers, or as a tool for development of simplified deceleration strategies. (Less)
The rising interconnectedness of the insurance sector

This paper examines the long-term evolution of the linkages of the insurance sector with financial and non-financial companies. We develop a measure of connectedness using a multifactor model of weekly equity returns. The empirical analysis is conducted from 1973 to 2018, for 16 developed countries, at both the sectoral and institution levels. The results indicate that, unlike other sectors, the connectedness level of the insurance industry has strengthened over time. We also find that the linkages of the largest insurance companies with financial and non-financial firms are structurally different but as high as those of the largest banks.
Synthesis, In Vitro Testing, and Biodistribution of Surfactant-Free Radioactive Nanoparticles for Cancer Treatment

New forms of cancer treatment, which are effective, have simple manufacturing processes, and easily transportable, are of the utmost necessity. In this work, a methodology for the synthesis of radioactive Gold-198 nanoparticles without the use of surfactants was described. The nuclear activated Gold-198 foils were transformed into H198AuCl4 by dissolution using aqua regia, following a set of steps in a specially designed leak-tight setup. Gold-198 nanoparticles were synthesized using a citrate reduction stabilized with PEG. In addition, TEM results for the non-radioactive product presented an average size of 11.0 nm. The DLS and results for the radioactive 198AuNPs presented an average size of 8.7 nm. Moreover, the DLS results for the PEG-198AuNPs presented a 32.6 nm average size. Cell line tests showed no cytotoxic effect in any period and the concentrations were evaluated. Furthermore, in vivo testing showed a high biological uptake in the tumor and a cancer growth arrest.
EXPLODING TECHNOLOGY AND LOW PERMEABILITY RESERVOIR IMPROVEMENT

The induction of exploding technology into petroleum industry was more than 100 years, and the industrial scale application of exploding technology was more than 20 years, it involved in perforation, fracturing and so on. The new improvement technologies for low permeability reservoir using exploding in well, such as nuclear explosion technology, high energy gas fracturing, loose by exploding, combination perforation, combination fracturing and so on are summarized. At the same time, the development of low permeability reservoir improvement using exploding technology is envisaged. At last, the combination operation of perforation, high energy gas fracturing, hydraulic fracture and exploding in fracture is considered as one of the optimize schemes for the improvement of low permeability reservoir.
Antimicrobial Peptides Epinecidin-1 and Beta-Defesin-3 Are Effective against a Broad Spectrum of Antibiotic-Resistant Bacterial Isolates and Increase Survival Rate in Experimental Sepsis

The antimicrobial peptides human Beta-defensin-3 (hBD-3) and Epinecidin-1 (Epi-1; by Epinephelus coioides) could be a promising tool to develop novel antibacterials to combat antibiotic resistance. The antibacterial activity of Epi-1 + vancomycin against methicillin-resistant Staphylococcus aureus (22 isolates) and Epi-1 + hBD-3 against carbapenem-resistant isolates of Klebsiella pneumoniae (n = 23), Klebsiella aerogenes (n = 17), Acinetobacter baumannii (n = 9), and Pseudomonas aeruginosa (n = 13) was studied in vitro. To evaluate the in vivo efficacy of hBD-3 and Epi-1, ICR (CD-1) mice were injected intraperitoneally with a lethal dose of K. pneumoniae or P. aeruginosa. The animals received a single injection of either sterile saline, hBD-3 monotherapy, meropenem monotherapy, hBD-3 + meropenem, or hBD-3 + Epi-1. Studied peptides showed antibacterial activity in vitro against all studied clinical isolates in a concentration of 2 to 32 mg/L. In both experimental models of murine sepsis, an increase in survival rate was seen with hBD-3 monotherapy, hBD-3 + meropenem, and hBD-3 + Epi-1. For K. pneumoniae-sepsis, hBD-3 was shown to be a promising option in overcoming the resistance of Klebsiella spp. to carbapenems, though more research is needed. In the P. aeruginosa-sepsis model, the addition of Epi-1 to hBD-3 was found to have a slightly reduced mortality rate compared to hBD-3 monotherapy.
Insomnia and Risk of Myocardial Infarction Among People with HIV.

BACKGROUND Insomnia is common among people with HIV (PWH) and may be associated with increased risk of myocardial infarction (MI). This study examines the association between insomnia and MI by MI type among PWH. SETTING Longitudinal cohort study of PWH at five Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) sites. METHODS Clinical data and patient-reported measures and outcomes (PROs) from PWH in care between 2005-2018 were utilized in this study. Insomnia, measured at baseline, was defined as having difficulty falling or staying asleep with bothersome symptoms. CNICS centrally adjudicates MIs using expert reviewers, with distinction between type 1 (T1MI) and type 2 MIs (T2MI). Associations between insomnia and first incident MI by MI type were measured using separate Cox proportional hazard models adjusted for age, sex, race/ethnicity, traditional cardiovascular disease risk factors (hypertension, dyslipidemia, poor kidney function, diabetes, smoking), HIV markers (antiretroviral therapy, viral suppression, CD4 cell count), and stimulant use (cocaine/crack, methamphetamine). RESULTS Among 12,448 PWH, 48% reported insomnia. Over a median of 4.4 years of follow-up, 158 T1MIs and 109 T2MIs were identified; approximately half of T2MIs were attributed to sepsis or stimulant use. After adjustment for potential confounders, we found no association between insomnia and T1MI (HR=1.05, 95%CI:0.76-1.45) and a 65% increased risk of T2MI among PWH reporting insomnia compared to PWH without insomnia (HR=1.65, 95%CI:1.11-2.45). CONCLUSIONS PWH reporting insomnia are at an increased risk of T2MI, but not T1MI, compared to PWH without insomnia, highlighting the importance of distinguishing MI types among PWH.
Experimental study on hysteretic model of SRC columns

Cyclic loading tests were conducted on 6 half scale SRC(steel reinforced concrete,SRC) columns.The effect of axial compression ratio and stirrup configuration on the seismic performance and hysteretic characteristics of SRC columns is especially investigated.Based on the test results,the effect of the change of axial compressive ratio on the hysteretic characteristics of SRC frame columns are investigated.Based on the experimental observations and the research results from other authors,a series of hysteretic rules for SRC columns is proposed.The skeleton curves are set up on the basis of a fiber section analyses and a statistic regression analysis.Finally,a restoring force model for shear force-top displacement relationship of SRC columns is presented,which is capable of considering the effect of axial compressive ratio on the hysteretic characteristics of columns.Comparisons between experimental and analytical shear force-top displacement relationships indicate that they are in good agreement with each other.
Modelers and Ethnographers as Co-Creators of Knowledge: Do We Belong Together?

In this paper, we explore the process of co-creation of knowledge between modelers and ethnographers through a project focusing on the role played by CIGS (Citizen initiatives for global solidarity) in the refugee crisis in the island of Lesvos, Greece. We describe the process of collaboration and discuss what this type of interdisciplinary collaboration may bring to the development of a research topic when the initial skepticism and questions of epistemological differences have been overcome. Moreover, we address some of the challenges embedded in this type of research collaboration, particularly the skepticism present within the social sciences.
Integrin-β4 regulates the dynamic changes of phenotypic characteristics in association with epithelial-mesenchymal transition (EMT) and RhoA activity in airway epithelial cells during injury and repair

Background: In airway disease such as asthma a hyperactive cellular event of epithelial-mesenchymal transition (EMT) is considered as the mechanism of pathological airway tissue remodeling after injury to the airway epithelium. And the initiation of EMT in the airways depends on the epithelial disruption involving dissolution and/or destabilization of the adhesive structures between the cells and ECM. Previously, we have shown that integrin-β4, an epithelial adhesion molecule in bronchial epithelium is an important regulator of cell proliferation and wound repair in human airway epithelial cells. Therefore, in this study we aimed to investigate whether integrin-β4 also regulates EMT phenotypes during injury and repair in airway epithelial cells of both wild type/integrin-β4-/- mice in vivo and cultured cells treated with integrin-β4/nonsense siRNA in vitro. Methods: We induced injury to the airway epithelial cells by either repeated exposure to ozone and mechanical scratch wound, and subsequently examined the EMT-related phenotypic features in the airway epithelial cells including biomarkers expression, adhesion and cytoskeleton reorganization and cell stiffness. Results: The results show that in response to injury (ozone exposure/scratch wound) and subsequent spontaneous repair (ozone withdrawal/wound healing) both in vivo and in vitro, the airway epithelial cells underwent dynamic changes in the epithelial and mesenchymal biomarkers expression, adhesion and cytoskeleton structures as well as cell stiffness, all together exhibiting enhanced EMT phenotypic features after injury and reversal of the injury-induced effects during repair. Importantly, these injury/repair-associated EMT phenotypic changes in airway epithelial cells appeared to be dependent on integrin-β4 expression. More specifically, when integrin-β4 was deficient in mice (integrin-β4-/-) the repair of ozone-injured airway epithelium was impaired and the recovery of ozone-enhanced EMT biomarkers expression in the airway epithelium was delayed. Similarly, in the scratch wounded airway epithelial cells with integrin-β4 knockdown, the cells were impaired in all aspects related to EMT during wound and repair including cell proliferation, wound closure rate, adhesion and cytoskeleton protein expression (vinculin and vimentin), mesenchymal-like F-actin reorganization, cell stiffness and RhoA activation. Conclusion: Taken together, these results suggested that integrin-β4 may be essential in regulating the effects of injury and repair on EMT in airway epithelial cells via influencing both the cell adhesion to ECM and cells' physical phenotypes through RhoA signaling pathway.
Energy and exergy analysis of a downstream single-row air washer at different droplet diameters for air cooling application

This study proposes a downstream single-row air washer for air cooling. The theoretical energy and exergy balance models were established at different droplet diameters and verified by the experimental data. Based on the abovementioned theoretical relationship, the single performance indicator of heat exchange efficiency (HEE) and exergy efficiency was quantitatively analyzed; a comprehensive analysis method of two indicators was proposed, combining HEE and exergy efficiency, and a numerical simulation was carried out. Results show that the smaller the droplet diameter and the larger the water–air ratio, the lower the dry-bulb temperature of the outlet air and the higher the HEE and exergy flux destruction. When the droplet diameter is less than 440 μm, the droplet diameter does not affect exergy efficiency and dry-bulb temperature. When the droplet diameter is larger than 440 μm, the droplet diameter is positively correlated with the air outlet dry-bulb temperature and exergy efficiency; in contrast, the water–gas ratio is negatively correlated with the air outlet dry-bulb temperature. An engineering case reveals that when the air outlet temperature is less than 34°C, the critical water–gas ratio can be set as 2.6 (mass ratio). At this time, the HEE is more than 90%, the exergy efficiency is more than 60%, and the critical value of droplet diameter is 440 μm. The research results provide an essential theoretical basis for the optimization of engineering design calculation.
Occurrence and Seasonal Monitoring of Domoic Acid in Three Shellfish Species from the Northern Adriatic Sea

As filter feeders, bivalves and ascidians can accumulate contaminants present in the environment and pass them on to higher food chain levels as vectors. The consumption of bivalves contaminated with the potent neurotoxin domoic acid (DA) can cause amnesic shellfish poisoning in humans. The aim of this study was to determine seasonal differences in occurrence and accumulation of this phycotoxin in European oysters (Ostrea edulis Linnaeus, 1758) (n = 46), Queen scallops (Aequipecten opercularis Linnaeus, 1758) (n = 53), and edible ascidians of the Microcosmus spp. (n = 107), originating from the same harvesting area in the Northern Adriatic Sea. The quantification was performed using ultra-performance liquid chromatography–tandem mass spectrometry (LC-MS/MS) preceded by derivatization with dansyl chloride. DA was found in very low concentrations throughout the year, with a maximum value of 810 μg/kg in Queen scallops. This study reveals differences in the occurrence and accumulation of DA between Queen scallops and the other two investigated species (oysters and ascidians) and the highest concentrations during the colder part of the year. Even though DA was detected in all of them, Queen scallops showed higher DA accumulation compared to the other two (p < 0.001), hence representing a sentinel species suitable for the monitoring of DA level in seafood.
High Stress Vibration Fatigue Test Technology of Aeroengine Blade

High stress vibration fatigue test of several aeroengine blades were carried out on electric shaker and the test mechanism was studied.New test methods were put forward,which were blade maximal vibration stress monitoring using assisting points and fixed frequency excitation after resonance frequency.Open loop control technology of vibrating table was successfully applied to stabilize vibration stress and reliable fatigue data were obtained.The relation between the excitation of electric shaker and the vibration response of blade was discussed.
Research on adaptive target tracking algorithm

Recently, many tracking algorithms based on correlation filtering are proposed, and good performance is obtained. Although these algorithms have extremely high accuracy, they cannot solve the tracking failure caused by cumulative errors and scene changes. So how to design a robust tracker is very import. An adaptive target tracking algorithm is proposed to achieve fast and robust tracking. For feature selection, we propose a hybrid feature based on HoG, CN, and Haar-like to express the tracked target from multiple angles such as color, edge, and detail. In order to solve the speed reduction caused by complex fusion features, we preset a simple classifier in the front end of the algorithm. The role of the classifier is to distinguish the difference between the target and the background, and to determine whether to use fusion features for tracking. Finally, we use simple mobile prediction to reduce the impact of accumulated errors. To evaluate the proposed algorithm, a wide range of experiments are performed using some of the OTB benchmarks.