Miracle-dz/UniFAR-FTUs huggingface dataset:
The Study on Neural Remodeling of Medullary Visceral Zone in Early Sepsis and Interfered by Cholinergic Anti-Inflammatory Pathway ​

BackgroundStudies including our own have shown that the Medullary Visceral Zone (MVZ) can effectively regulate systemic inflammation and immunity through the Cholinergic Anti-inflammatory Pathway (CAP). Sepsis usually causes neuroinflammation in the Central Nervous System (CNS), which will inevitably affect the structure and function in related brain areas such as MVZ, whether the intervention of CAP can affect the structure and function of the MVZ in sepsis needs to be further verified. Methods64 adults, specific pathogens free Sprague-Dawley male rats were used in this study. The septic models were prepared by cecum ligation and puncture (CLP) method, GTS-21 (a selective α7 nicotinic acetylcholine receptor agonist which can mimic CAP’s activation) and MLA (a powerful and selective nicotine acetylcholine receptor antagonist which can mimic CAP’s blocking) were used to interfere CAP. The pathological changes, apoptosis, the expressions of Tyrosine Hydroxylase (TH) and Choline acetyltransferase (CHAT), the expression levels of GAP-43 mRNA, Olig-2 mRNA, VEGF mRNA, GFAP mRNA, MMP-9 mRNA in MVZ were analyzed among different groups. ResultsIn this study, we found that sepsis induced apoptosis and functional suppression of catecholaminergic and cholinergic neurons and gliosis in MVZ, up-regulated key genes’ expressions such as GAP-43 mRNA，GFAP mRNA，VEGF mRNA，MMP-9 mRNA, down-regulated the expression of Olig-2 mRNA. GTS-21, a selective α7 nicotinic acetylcholine receptor agonist, obviously mitigated the above changes; whereas, methyllycaconitine (MLA), a powerful and selective nicotine acetylcholine receptor antagonist, significantly aggravated these changes. ConclusionsOur research shows that activating CAP can effectively mitigate the neural remodeling and neuronal suppression induced by early sepsis in MVZ, the mechanism may involve with its control of systemic and local inflammation. This study reveals that MVZ and CAP may be potential targets to curb the inflammatory storm in early sepsis.
Are you Healthy and Happy? A Cross-Sectional Study on Mental Health and Happiness among University Student-Athletes in Malaysia

Despite its successful academic achievement, Malaysian students suffer from poor mental health. Various sources of poor mental health reported and playing dual roles as student-athletes could be more stressful. How happy these students are yet to be explored with their mental health. Thus, this study aimed to explore the mental health and happiness among university student-athletes and their differences with demographic variables. Participants were university student-athletes who competed in Sukan Institut Pengajian Tinggi (SUKIPT) (N = 364). A stratified sampling technique was employed in selecting the participants through self-administered questionnaires. The instruments used were the General Health questionnaire (GHQ) and Oxford Happiness Questionnaire (OHQ) to measure mental health and happiness of the participants. Findings revealed that the athletes have a moderate mental health and considerable happiness. The female athletes were significantly happier than the male athletes (p < .05), while the mental health exhibited no significant difference (p > .05). The results also revealed no significant relationship between mental health and happiness (p > .05). Higher institutions should pay attention to the student- athletes’ sports and academic demand to prevent mental health issue.
Wound healing and Antigenotoxic activities of Aegle marmelos with relation to its antioxidant properties

Aegle marmelos Linn. is a perennial tree belonged to the family Rutaceae found in the central and South India which is commonly known as Bael in Hindi, Vilvam in Tamil and Bilva in Sanskrit. Leaves and fruits of Aegle marmelos are used in folk medicines and by the Ayurvedic practitioners. Oxidative stress is produced during the normal metabolic process in the body as well as induced by a variety of environmental and chemical factors and natural radiation, which cause generation of various reactive free radicals and subsequent damage to macromolecules like DNA, proteins and lipids. Antioxidant activity of Aegle marmelos plants might be due to the presence of phenolic compounds such as flavonoids. This study reveals the antioxidant potentials of Aegle marmelos methanolic extracts of leaves. Standard methods were adopted to screen phytochemical nature, antioxidant, wound healing and antigenotoxic properties of A. marmelos leaves. Results of phytochemical screening of the aqueous extract revealed the presence of steroid, terpinoids, saponins, tannis, lignin, flavonoids. In-vivo antioxidant activity of the methonolic leaf extracts revealed that the leaf extracts to possess good antioxidant power to heal the wounds in mice models equivalent to that of the providine iodide used as a standard compound. Based on the results, it can also be concluded that extracts of Aegle marmelos leaves were found to be an antigenotoxicant. Further studies are required to identify specific active principles of this plant for the significant antioxidant effect.
Application of the end-of-season stalk nitrate test for a high-yield maize production system in Northwestern China

ABSTRACT Excessive nitrogen application has caused serious environmental pollution under high-yield maize system in China. Our objective was to evaluate critical stalk nitrate (NO3−) levels that support high yield (>13 Mgha−1), but are not in excess. Optimal stalk NO3− concentration was determined by conducting seven nitrogen levels experiments in two high yield maize regions: Dongyang County (DY) and Wenshui County (WS). Optimal stalk NO3− concentration category range to obtain maximum yield in DY (sandy loam, higher accumulated temperature and solar radiation compared with WS) was 0.44–1.19, which similar to the criteria of US (0.70–2.0 g kg−1). While for WS (loam soil, lower accumulated temperature and solar radiation compared with DY), optimal stalk NO3− concentration category range to obtain maximum yield was 1.95–4.15, greatly higher than the US criteria. These results suggested thatit is necessary to establish matching optimal stalk NO3− category ranges for different ecological regions in China.
Atmospheric plasma-enhanced spatial-ALD of InZnO for high mobility thin film transistors

In this manuscript, the authors investigate the growth of indium zinc oxide, indium zinc oxide (InZnO, IZO) as a channel material for thin-film transistors. IZO is grown at atmospheric pressure and a high deposition rate using spatial atomic layer deposition (S-ALD). By varying the ratio of diethylzinc and trimethylindium vapor, the In/(In þ Zn) ratio of the film can be accurately tuned in the entire range from zinc oxide to indium oxide. Thin film transistors with an In to Zn ratio of 2:1 show high field-effect mobility—exceeding 30 cm2/V s—and excellent stability. The authors demonstrate large scale integration in the form of 19-stage ring oscillators operating at 110 kHz. These electrical characteristics, in combination with the intrinsic advantages of atomic layer deposition, demonstrate the great potential of S-ALD for future display production.
Rekomendasi Pemilihan Restoran Berdasarkan Rating Online Menggunakan Algoritma C4.5

Restoran adalah suatu usaha yang menyediakan tempat untuk menikmati hidangan kepada pelanggan serta menetapkan tarif tertentu. Tersedianya banyak pilihan restoran menjadi faktor penting yang dibutuhkan dalam memilih restoran. Masalah akan muncul secara langsung akibat banyaknya restoran yang tersedia sehingga membutuhkan waktu yang lama untuk menentukan pilihan. Hal ini disebabkan oleh penyebaran informasi yang tidak merata dan pengambilan keputusan yang tidak akurat sehingga pelanggan kesulitan untuk menentukan pilihan restoran. Dengan adanya rekomendasi pemilihan restoran untuk pelanggan akan mendukung pengambilan keputusan dalam menentukan restoran atau tempat makan. Latar belakang dipilihnya algoritma C4.5 sebagai pengambilan keputusan untuk menentukan rekomendasi pemilihan restoran berdasarkan rating. Data yang digunakan diambil dari Zomato API untuk dilakukan pengujian dengan menggunakan 1003 sampel data restoran. Hasil yang didapatkan dengan ten-fold cross validation yaitu menghasilkan akurasi 86,24% dengan rating yang paling dominan dan sesuai untuk direkomendasi adalah Rating Good. Hal ini diharapkan dapat memberikan rekomendasi untuk menentukan beberapa pilihan restoran yang sesuai untuk dikunjungi berdasarkan rating tersebut.
Water diffusion in silica glass through pathways formed by hydroxyls

Abstract Water diffusion in silicate melts is a fundamental process controlling physical and chemical consequences for magmatism, but mechanisms of diffusion in silicate glasses and melts are not fully understood. In this study, water diffusion experiments in silica glass were performed at temperatures of 650–850 °C and water vapor pressure of 50 bar, with the aim of improving our understanding of the mechanism of water diffusion in a simple SiO2-H2O system, and to construct a general water diffusion model for multi-component silicate glasses. Hydrogen diffusion profiles in silica glass were measured by secondary ion mass spectrometry (SIMS) down to a water concentration of ~10 ppm. Water diffusion profiles indicate that water diffusion becomes slower with decreasing water concentration in silica glass, with the water concentration dependence being greater than in multi-component silicate glasses, particularly at low concentrations (e.g., Doremus 1969, 2000; Zhang and Behrens 2000). A new water diffusion model is proposed for silica glass, where the greater concentration dependence is attributed to the limited number of diffusion pathways in silica glass, formed by breaking Si–O–Si bonds through hydroxyl formation. The model was applied to multi-component silicate glasses, taking into account the effects of metal cations that act as network modifiers by providing additional diffusion pathways for water molecules. The lower water concentration dependence in multi-component silicate glasses and melts is explained by little dependence of the number of diffusion pathways on water concentration because it is controlled extrinsically by network modifier cations. It is concluded that the number of diffusion pathways is an essential controlling factor for water diffusion in silica and silicate glasses.
Crowdsourcing as an Opportunity for a Responsible Investment Fund? A French Case Study

In modern society, entrepreneurial practices have evolved through the emergence of sustainable development (SD), corporate social responsibility (CSR) initiatives, the consolidation of traditional sectors in the social economy (SE) and the rise of social innovation through technological innovation. In addition, advances in information and communication technology (ICT) enable the general public to become more easily involved in organisational transformations. The term ‘crowdsourcing’ applies to projects that are jointly created by project initiators and citizens. This article addresses the question of whether these citizens, that is, ‘crowds’, should become more involved in sustainable financing organisations that seek legitimacy and socioeconomic efficiency. Ultimately, the question concerns the ability of those responsible for sustainable financing to incorporate these new forms of public involvement and provide appropriate financing for societal challenges. Is it possible for these actors to do this? If so, under what conditions, and how will they have to evolve? A longitudinal case study is carried out to develop a regional ethical, solidarity and crowdfunding investment fund in which the role of the public is clearly defined. We identify the range of possibilities in organisational transformations that are taking place amongst sustainable financing actors.
Making Islamic University and Madrasah as Society’s Primary Choice

Islamic university and Islamic-Based School (madrasah) in Indonesia can be the primary choice of society if adequately managed through the right strategic programs and efforts. This study used field and literature data. This study proved that since 1970 Islamic University and Madrasah became the choice of the upper-middle-class Muslim community. This situation can increase or decrease, depending on reliable teamwork that is willing to work with commitment and high moral responsibility.
Raman spectroscopy of weathered shungites

Raman spectroscopy has proven to be a useful tool for the study of carbonaceous material (CM). This method is used to distinguish various types of CM and to study the evolution of Raman spectra characteristics of CM during metamorphic transformations. In the present study, we applied the Raman spectroscopy and electron diffraction methods to investigate the evolution of structural ordering of CM of shungite rocks, Karelia (Russia), during weathering. The studies of the CM structure evolution during weathering are rare and ambiguous. The Raman spectra of weathered shungites are characterized by increase of FWHM-D1, that is accompanied by the decrease of intensity-based ratio R1 = ID/IG and the change of the intensity of the bands in second-order region. The Raman spectral data indicate that weathering results in the alteration of both intralayer and interlayer ordering of shungites, but there are some peculiarities for the shungites subjected to the various types of weathering. The present study establishes that the Raman spectra characteristics of weathered shungites can be used as the indicators of weathering for CM from various carbon-bearing rocks. Copyright © 2017 John Wiley & Sons, Ltd.
Intention-aware for Session-based Recommendation with Multi-channel Network

Session-based recommendation predicts the user’s next action by exploring the item dependencies in an anonymous session. Most of the existing methods are based on the assumption that each session has a single intention, items irrelevant to the single intention will be regarded as noises. However, in real-life scenarios, sessions often contain multiple intentions. This paper designs a multi-channel Intention-aware Recurrent Unit (TARU) network to further mining these noises. The multi-channel TARU explicitly group items into the different channels by filtering items irrelevant to the current intention with the intention control unit. Furthermore, we propose to use the attention mechanism to adaptively generate an effective representation of the session’s final preference for the recommendation. The experimental results on two real-world datasets denote that our method performs well in session recommendation tasks and achieves improvement against several baselines on the general metrics.
GREEN ECONOMY: DEVELOPMENT IN THE LIGHT OF NEW POLICY

The purpose of the paper is to study the current problems of ecology and environmental protection, which is associated with the current sustainable trends in economic development. The growth of the world economy as a whole and the economic progress of most developed countries with market relations tends to an increasing use of natural resources and at the same time to an increasing depletion and pollution of the environment. The goal is to determine the essence, prerequisites for the emergence and development of the green economy as a modern concept of interaction between society and nature through the economy, as well as reflect the prerequisites for the activation of the green movement on a global scale in order to preserve nature and ensure the natural conditions of human habitation. The topic of the article is due to the need to disclose modern economic dynamics and rates of social progress and their impact on the environment. In this regard, the essence of the green economy, directions and principles of its implementation for the restoration and strengthening of natural potential are considered. Methodology. A correct assessment and analysis of the dynamics and trends in the development of the world economy in terms of increasing economic potential and increasing the production of economic benefits to ensure the welfare of society allows us to assess the level of impact on nature and the environment. Without the results of these assessments and calculations, significant errors appear in the choice of state priorities for socio-economic policy and in making optimal decisions in the field of production. The study is based on an assessment of the interaction between the world economy and the environment in modern conditions. Results. The questions of modern economic trends in nature and environment are studied. The need for the implementation of the green economy in modern conditions has been determined. The necessity to preserve nature and reduce environmental pollution is becoming more and more urgent. Practical implications. The state of the natural environment and the possibilities of preserving and improving the environment are being studied. An adequate assessment of the state of nature and natural resources will allow the world community to pursue a balanced and effective socio-economic and environmental policy for the harmony of society and nature where it lives. Value/originality. It has been determined that nature is the basis of social life, and at the same time, its preservation is the main goal of social progress. The economy is just the means by which nature creates welfare for society. Nature can exist without humanity, but humanity cannot exist without nature. Therefore, the preservation and strengthening of the environment are more than relevant. To this end, a green economy policy is being implemented in the modern world.
Flexible Computationally Efficient Platform for Simulating Scan Formation in Optical Coherence Tomography with Accounting for Arbitrary Motions of Scatterers

A computationally efficient and fairly realistic model of OCT-scan formation in spectral-domain optical coherence tomography is described. The model is based on the approximation of discrete scatterers and ballistic character of scattering, these approximations being widely used in literature. An important feature of the model is its ability to easily account for arbitrary scatterer motions and computationally efficiently generate large sequences of OCT scans for gradually varying configurations of scatterers. This makes the proposed simulation platform very convenient for studies related to the development of angiographic processing of OCT scans for visualization of microcirculation of blood, as well as for studies of decorrelation of speckle patterns in OCT scans due to random (Brownian type) motions of scatterers. Examples demonstrating utilization of the proposed model for generation OCT scans imitating perfused vessels in biological tissues, as well as evolution of speckles in OCT scans due to random translational and rotational motions of localized (but not-point-like) scatterers are given. To the best of our knowledge, such numerical simulations of large series of OCT scans in the presence of various types of motion of scatterers have not been demonstrated before.
Protective effect of Parthenium hysterophorus against carbon tetrachloride- and paracetamol-induced hepatotoxicity in rabbits

Purpose : To investigate the possible hepatoprotective potential of Parthenium hysterophorus crude extract (Ph.Cr) against carbon tetrachloride (CCL4)- and paracetamol-induced hepatotoxicity in rabbits. Methods : Twenty rabbits were divided into five groups of four rabbits each. Group 1 served as normal control and received normal saline (5 mL/kg). Group 2 received normal saline followed by CCL4 (0.75 mL/kg p.o dose) after 1 h. Groups 3 and 4 received Ph.Cr at doses of 15 and 30 mg/kg po, respectively, for 7 days followed by one dose of CCL4, 2 h after the last extract dose (0.75 mL/kg, sc). Group 5 received silymarin as reference standard at a dose of 100 mg/kg orally for 7 days followed by one dose of CCL4 (0.75 mL/kg, sc), 2 h after the last drug dose. The effect of the extract on potassium (K+)- induced contractions in isolated rabbit jejenum was also evaluated. At the end of the study, the animals were sacrificed and their liver architecture examined microscopically. Results : Pre-treatment of rabbits with Ph.Cr reduced ALT, ALP and TB levels (p < 0.05, p < 0.01, p < 0.001) dose dependently. Hepatoprotective data indicate that Ph.Cr markedly reduced CCL4- and paracetamol-induced toxicity by preserving the histological architecture of the liver tissue at near normal. In isolated rabbit jejunum tissue, Ph.Cr relaxed high K+ (80 Mm)-induced contractions in a concentration-dependent (0.03 - 10 mg/mL) manner like that caused by silymarin. Conclusion : In the light of the results obtained, Parthenium hysterophorous possesses hepatoprotective activity against CCL4- and paracetamol-induced hepatic damage, possibly mediated via its antioxidant and Ca++ antagonist mechanisms. Keywords : Parthenium hysterophorus, Toxins, Hepatoprotection, Ca++ antagonist, Silymarin
Classification and Evaluation on Shale Gas Reservoir for Wufeng-Longmaxi Formation in Chuannan Area, Sichuan Basin

Based on the comprehensive statistic and analysis on some representative geological and physical data, the classification criteria on net pay for shale gas reservoir of the Wufeng-Longmaxi formation in Shunan area, Sichuan Basin, are proposed, which include porosity (φ), gas saturation (Sg), density of rock (DEN), brittleness index (BI), and gas content (Vt). When the porosity, gas saturation, brittleness index, and gas content are larger than 3%, 30%, 40%, and 1 m3/t, respectively, and the density of rock is lower than 2.7 g/cm3, then this formation can be seen as the net pay. The application of two key parameters, gas content and brittleness index, could reflect the reservoir resource basis and fracability, respectively. The gas content has a positive correlation with porosity and total organic volume, and the brittleness index has a positive correlation with siliceous and carbonate content. According to the range of these two parameters, the net pay can be classified into three types. For type I, the gas content and brittleness index are larger than 4 m3/t and 50%, respectively. For type II, either the gas content or the brittleness index is lower than 4 m3/t and 50%. For type III, the gas content should be larger than 1 m3/t and lower than 4 m3/t, and the brittleness index is between 40% and 50%. The field application case indicates that the Wufeng formation and low member of the Longmaxi formation have good quality and mainly consist of type I and II formations. In addition, it is found that there is a positive correlation between the penetration ratio for type I formation and the testing production and estimate ultimate recovery (EUR). While this ratio is larger than 50%, the testing production rate and EUR will be over 15×104 m3/d and 8000×104 m3 with a probability of 92%, which meet the requirement of exploitation with reasonable economic benefits.
Motor oil wastewater treatment in a packed bed bioreactor using immobilized native microbial consortium

Waste motor oil generates contamination in water due to its inappropriate disposal and is hence considered a hazardous residue. In this study a native microbial consortium was isolated from soil contaminated with waste motor oil. The ability to grow, biosurfactant production, and degradation of different oil concentrations (0.2, 0.5, 1.0, and 2.5 % v v-1) was analyzed. The growth kinetic analysis revealed the value of the maximum specific growth rate was 0.758 d1, while the saturation constant was 0.781 % v v-1 (7.11 mg mL-1) and the inhibition constant, 2.60 % v v-1 (23.77 mg mL-1). Waste motor oil (1.0% v v-1) was used in the biodegradation oil studies using a packed-bed bioreactor and native microbial consortium immobilized over plastic rings. The results obtained showed the biosurfactant production capacity was 398.18 mg L-1 and the efficiency of waste motor oil was 67.76%. The results obtained in the present work represent a significant advantage in bioremediation of oil contaminated water.