Miracle-dz/UniFAR-FTUs huggingface dataset:
Tortricidae Codling Moth , Cydia pomonella ( Lepidoptera : Tortricidae ) – Major Pest in Apple Production : an Overview of its Biology , Resistance , Genetic Structure and Control Strategies

Th e codling moth Cydia pomonella (CM) (Linnaeus) is a key pest in pome fruit production with a preference for apple. Th e pest is very adaptable to diff erent climatic conditions and is known for developing resistance to several chemical groups of insecticides. Because of these reasons, the populations of codling moth are differentiated in many ecotypes of various biological and physiological development requirements. Th e article provides a bibliographic review of investigation about: morphology, biology, dispersal, damages, resistance to insecticides, population genetic structure and genetic control of this pest.
Genomic expansion of Marek's disease virus DNA is associated with serial in vitro passage

An EcoRI restriction endonuclease pattern of Md11 virus DNA, a very virulent strain of Marek's disease virus (MDV), was obtained by using total cellular DNA from infected cells. With the EcoRI restriction endonuclease pattern and a published BamHI map of MDV (Fukuchi et al., J. Virol. 51:102-109), we constructed a partial EcoRI map of a series of MDV clones (gift from H. J. Kung). The clones were used to identify a region of the Md11 genome which is altered as the oncogenic virus is passaged in vitro. This region was mapped into a 1.8-kilobase segment in the inverted-repeat sequences flanking the long unique region of the virus genome. The alteration appeared to result from multiple DNA insertions that produced an increase of 0.6 to 5.4 kilobases. Although the expansion of this region did not diminish the ability of MDV to replicate in vitro, it may be associated with the loss of Marek's disease oncogenicity.
Congenital Adrenal Hyperplasia due to 11-Hydroxylase Deficiency – Insights from Two Novel CYP11B1 Mutations (p.M92X, p.R453Q)

Background: Steroid 11-hydroxylase (CYP11B1) deficiency (11OHD) is the second most common form of congenital adrenal hyperplasia (CAH). Herein, we describe two novel CYP11B1 mutations (g659_660dupTG, p.M92X; g.4817G>A, p.R453Q) found in a patient diagnosed with classic 11OHD, after presenting with borderline elevated 17-hydroxyprogesterone concentrations in CAH newborn screening. Methods: A novel CYP11B1 variant (p.R453Q) identified in a patient with classic 11OHD was characterized employing a COS7 cell assay and a computational three-dimensional CYP11B1 model. Results: The in vitro expression analysis revealed an almost complete loss of function of p.R453Q. This finding was consistent with the clinical presentation of classic 11OHD as the patient was compound heterozygous for p.R453Q and a nonsense mutation (p.M92X) on the other allele. Inserting the p.R453Q mutation into our CYP11B1 model provided two potential explanations for the almost complete loss of enzyme activity. Firstly, the heme coordination is most likely disturbed. A second possibility could be an altered interaction with the redox partner adrenodoxin. Conclusion: Results indicate that both novel mutations are disease-causing mutations. Proving the pathogenic effect of a missense sequence variation is of particular importance for clinical genetic counseling as this provides essential information on the prediction of recurrence risk and disease severity.
GISQAF: MapReduce guided spatial query processing and analytics system

The Global Database of Event, Language, and Tone (GDELT) is the only global political georeferenced event dataset with more than 250 million observations covering all countries in the world since January 1, 1979. TABARI and CAMEO are the tools that are used to collect and code events from all international news coverage. To query such big geospatial data, traditional RDBMS can no longer be used, and the need for parallel distributed solutions has become a necessity. MapReduce paradigm has proven to be a scalable platform to process and analyze Big Data in the cloud. Hadoop, as an implementation of MapReduce, is an open‐source application that has been widely used and accepted in academia and industry. However, when dealing with Spatial Data, Hadoop is not equipped well and does not perform efficiently. SpatialHadoop is an extension of Hadoop with the support of spatial data. In this paper, we present Geographic Information System Query and Analytics Framework (GISQAF), which has been built on top of SpatialHadoop. GISQAF focuses on two parts: query processing and data analytics. For the query processing part, we show how this solution outperforms Hadoop query processing by orders of magnitude when applying queries on the GDELT dataset with a size of 60 GB. We show the results for various types of queries. For the data analytics part, we present an approach for finding Spatial co‐occurring events. We show how GISQAF is suitable and efficient to handle data analytics techniques. Copyright © 2015 John Wiley & Sons, Ltd.
Synthesis and Structure of an Iron(III) Sulfide-Ferritin Bioinorganic Nanocomposite

Amorphous iron sulfide minerals containing either 500 or 3000 iron atoms in each cluster have been synthesized in situ within the nanodimensional cavity of horse spleen ferritin. Iron-57 M�ssbauer spectroscopy indicated that most of the iron atoms in the 3000-iron atom cores are trivalent, whereas in the 500-iron atom clusters, approximately 50 percent of the iron atoms are Fe(III), with the remaining atoms having an effective oxidation state of about +2.5. Iron K-edge extended x-ray absorption fine structure data for the 500-iron atom nanocomposite are consistent with a disordered array of edge-shared FeS4 tetrahedra, connected by Fe(S)2Fe bridges with bond lengths similar to those of the cubane-type motif of iron-sulfur clusters. The approach used here for the controlled synthesis of bioinorganic nanocomposites could be useful for the nanoscale engineering of dispersed materials with biocompatible and bioactive properties.
Elder Abuse in a Developing Area in Bolivia

In many parts of the world, elder abuse happens almost unnoticed. Until recently, this serious social problem was hidden from public view and was regarded as an essentially private matter. However, there is growing evidence that elder abuse is an important problem of public health and in the society. The objective of this study is to determine the degree of abuse of elder and vulnerable people in the families and communities of Eastern Bolivia. With this end in mind, we conducted a cross-sectional descriptive study with a sample size of 210 60-year-old people coming from different health care areas. Elder Abuse Suspicion Index (EASI) and Yaffe’s Evaluation Form of Social Work were used. An abuse rate of 39% of the older adults was identified. The most common type of abuse observed was psychological abuse (32.4% of cases), followed by neglect (21.9%). Children were identified as triggers of the abuse in 66.7% of cases of abuse. The prevalence of elder abuse was similar to the prevalence of other types of abuse that exist in Bolivia, such as the gender-based abuse. Also, this prevalence is comparable to other developing countries and European countries. The profile of abused older adult is as follows: woman, widow, 70 years old, incomplete primary education, without an occupation, and an average of 4.59 children. The information obtained shows that dysfunctional families have a higher percentage of elder abuse.
A Genetic Algorithm Based Clustering Approach with Tabu Operation and K-Means Operation

Clustering analysis is a nonconvex problem that possesses many locally optimal values, with the result that its solution often falls into these traps. In this article, a hybrid genetic clustering algorithm called Genetic algorithm with Tabu operation and K-means operation based Clustering (GTK-Clustering) is developed to deal with the clustering problem. With the cooperation of tabu operation and Λ-means operation, the GTKClustering algorithm can keep a balance between population diversity and the speed of convergence. On the one hand, the tabu operation prevents the population from being dominated by several fitter individuals and maintains a high level of population diversity, and on the other hand, the λ-means operation improves the distribution of objects and enhances the speed of convergence of the clustering algorithm. Its superiority over the Λ-means algorithm and another genetic clustering approach is demonstrated for artificial and real life data sets.
COMPARATIVE AND ONTOGENIC BIOCHEMISTRY In silico Analysis of Paraoxon Binding by Human and Bovine Serum Albumin

Albumin is known to be able to cleave ether bonds in organophosphates (OPs). Amino acids responsible for esterase and pseudo-esterase albumin activity towards OPs are not yet finally identified. Presumably, Sudlow’s site I with the Tyr150 residue shows a “true” esterase activity, while Sudlow’s II site with the Tyr411 residue—a pseudo-esterase one. Both human (HSA) and bovine (BSA) serum albumins were used in in vitro studies of albumin (pseudo)esterase activity towards OPs. There is a body of evidence that the efficiency of interaction of different xenobiotics differs for these two proteins. Using paraoxon as an example, the aim of this study was to conduct an in silico study of the OP interaction with the previously identified potential sites of HSA and BSA (pseudo)esterase activity, to estimate the possibility of enzymatic reactions at these sites, to comparatively analyze these proteins from the evolutionary viewpoint, and to assess the possibility of extrapolating the experimental data obtained on BSA to a human organism. Molecular docking of paraoxon into the sites of HSA and BSA potential (pseudo)esterase activity has been performed. Conformational changes occurring in the resultant complexes with time have been studied by molecular dynamics simulation. It has been shown that Sudlow’s site II is less liable to evolutionary changes. Binding of modulators at other sites is not required for productive sorption of OPs and the phosphorylation reaction at Sudlow’s site II. It has been concluded that simi lar results for HSA and BSA could be expected for the irreversible binding of OPs at Sudlow’s site II. Since Sudlow’s site I is less conservative, diff erent binding efficiency could be expected for rigid molecules or optically active compounds. Both for HSA and BSA, productive binding of OPs at Sudlow’s site I is possible only after changes in the albumin molecule structure induced by binding of modulators at other sites. DOI: 10.1134/S0022093017030036
Gender, Ethnocultural, and Psychosocial Barriers to Diabetes Self-Management in Italian Women and Men With Type 2 Diabetes

Although several ethnic groups experience a greater burden of diabetes, this has not been examined in first-generation Italians, who compose one of the largest ethnocultural groups in Canada. In this cross-sectional study, the authors examined the relationship among gender and ethnocultural factors, family support, depressive symptomatology, and illness perceptions on diabetes self-management (DSM) in 50 Italian women and men with type 2 diabetes. The authors first conducted a focus group to explore cultural barriers. They then assessed gender, ethnocultural, and psychosocial barriers quantitatively by an interviewer-administered questionnaire, Compared with Italian men, Italian women reported significantly greater depressive symptomatology and perceived disease seriousness. Greater depressive symptomatology was significantly associated with perceived family sabotage and DSM barriers. In univariate analyses, shorter duration of diabetes and greater perceived treatment effectiveness significantly predicted better DSM. In conclusion, certain illness perceptions and culturally relevant gender-specific barriers should be addressed by health care providers to maximize DSM in this population.
Two Newly Diagnosed HLA Class II-Deficient Patients Identified by Rapid Vector-Based Complementation Analysis Reveal Discoordinate Invariant Chain Expression Levels

Background: Primary immunodeficiencies represent the ‘molecular Achilles’ heels’ of human immunity. Detailed analyses of primary immunodeficiencies extend our knowledge of pivotal immunological processes, lead to novel diagnostic algorithms and shorten the time to diagnosis. Methods: Clinical/immunological phenotypes of 2 unrelated patients from Austria with combined immunodeficiency were determined. Leukocyte subpopulations of these patients, their parents and healthy controls were analyzed by flow cytometry. Patient-derived Epstein-Barr virus (EBV)-transformed B cell lines were established and complemented by candidate cDNAs. Suspected mutations were confirmed by DNA sequencing. Results: Phenotyping revealed a lack of constitutive human leukocyte antigen (HLA) class II expression on antigen-presenting cells of both patients, compatible with MHC class II deficiency. Rapid vector-based complementation analysis of the patients’ B cells identified HLA class II transactivator (CIITA) deficiency in patient VIP1 and regulatory factor X (RFX)AP deficiency in patient VIP2. CIITA deficiency was caused by a homozygous p.Glu381X mutation. RFXAP deficiency resulted from a homozygous p.Ser123ThrfsX15 mutation, not described in the Middle European population so far. Of note, HLA class II-associated invariant chain (Ii) expression levels were significantly reduced in VIP1 and 3 additional EBV-transformed B cell lines of CIITA-deficient patients but normal in EBV-transformed B cells from VIP2. In addition, peripheral blood B cells from the parents of VIP1 showed significantly reduced HLA-DR and -DP expression levels compared to healthy controls. Conclusions: Analysis of patients’ intracellular Ii and their parents’ surface HLA class II expression levels might help to identify CIITA-deficient patients already during initial phenotyping.
Prospective hatching of embryos developed from oocytes exhibiting difficult oolemma penetration during ICSI.

BACKGROUND The hormonal milieu during ovarian stimulation is known to affect oolemma behaviour as well as zona pellucida thickness and structure. This led us to investigate whether a special subgroup of patients with oocytes where penetration of the oolemma is difficult during ICSI may benefit from assisted hatching. METHODS A total of 77 couples (mean age: 32.9 +/- 4.6 years; range: 22-38) had oocytes that could hardly be penetrated by the ICSI pipette. Nineteen patients underwent two ICSI cycles, giving a total number of 96 cycles, which were randomly split into either the study group (n = 52) or the non-hatching group (n = 44). Hatching was done using a non-contact 1.48 mm wavelength diode laser. Implantation and pregnancy rates were recorded. RESULTS The pregnancy rate was 36.6% (19/52) in the study group and 13.6% (6/44) in the non-hatching group (P < 0.05). In addition, a higher number (P < 0.05) of embryos implanted in the study group (23/106; 21.7%) than in the non-hatching group (9/92; 9.8%). CONCLUSIONS Once oolema penetration during ICSI has proven difficult, prospective hatching of embryos considered for transfer may increase their implantation behaviour.
Computational approach to site‐directed ligand discovery

A computational approach, Systematic Conformational Search & Induced Fit (SCI&FI), to site‐directed ligand discovery (Tethering®) is presented. SCI&FI has the ability to predict the binding site, binding mode, and bound dynamics of small molecule fragments covalently tethered to a protein. The SCI&FI method was engineered with the ability to model induced fit conformational changes of the protein because of the binding of the tether. SCI&FI generates comprehensive picture of the binding preferences of the tether to the protein by elucidating potential binding sites of the tether and by describing regions of receptor space capable of conformational change because of the binding of the tether. The SCI&FI method provides a complementary approach to experimental tethering. Initial validation of the SCI&FI method is reported by predicting the 3D structure of two Interleukin‐2 and an Interleukin‐4 tethered‐protein systems. Proteins 2007. © 2007 Wiley‐Liss, Inc.
Measuring Job Stress and Family Stress in Chinese Working Women: A Validation Study Focusing on Blood Pressure and Psychosomatic Symptoms

ABSTRACT Psychometric properties of a questionnaire measuring psychosocial work-related stress in terms of effort-reward imbalance and a short family stress scale were examined in a population sample of 421 working women from four work sites in Beijing, China. The internal consistency of the scales was satisfactory, and the theoretically postulated structure of scales of the work stress questionnaire was replicated. The criterion validity of the scales was tested using psychosomatic symptoms and blood pressure. Combined exposure to work and family-related stress was associated with an adjusted mean 6.4 mmHg increase in systolic blood pressure. Recurrent sleeping problems were also associated with the two stress measures. In conclusion, standardized measures of psychosocial stress in terms of effort-reward imbalance and of family stress can be used in occupational health research in China, with particular relevance for working women.
Application of gold nanoparticle self-assemblies to unclonable anti-counterfeiting technology

Counterfeits are now world-wide issue. An anti-counterfeit technology with high security level (unclonable), high through-put rate of authentication, and low cost is desirable. Nanotag of plasmonic nanostructure with surface enhanced Raman scattering (SERS) activity is promised for the ideal authentication. The gold nanoparticle (AuNP) self-assemblies were applied to SERS active “stealth nanobeacon” for authentication. Mild deposition of aqueous dispersion of self-assembled AuNP was used. 10 ng AuNP assemblies deposited on a commercial medicine tablet were almost invisible to the eye. Distinguishable SERS signals of reporting molecules was produced by 1s irradiation of 785 nm laser over the nanobeacon, while Raman spectrum of the ingredients was observed on the tablet without the nanobeacon. Rapid authentication of tablets stocked for 60 days was sufficiently carried out. It is considered that the presence of discrete AuNP assemblies allows excellent performances of stealth nanobeacon.
ÜNİVERSİTE GENÇLİĞİNİN MEDYA KULLANMA ALIŞKANLIKLARI ÜZERİNE BİR ANALİZ

Turkiye yetmismilyonu asan nufusu ve yakaladigiekonomik buyuklukle dunyanin onemli ulkelerinden biri durumuna gelmistir. Bir Avrupa ulkesi kadar refah seviyesine ulasamayan ve gelir dagiliminin oldukca bozuk oldugu ulkemizde, insanlar bilgiyi genellikle medya vasitasiyla elde etmektedirler. Turkiye’de insanlarin gundelik yasantisinidoldurmada medya buyuk bir rol ustlenmistir. Genc nufusun oldukca fazla oldugu ulkemizde, ozellikle egitim caginda bulunan universite ogrencilerinin genel olarak medya izleme aliskanliklaribu calismanin konu eksenini olusturmustur. Ogrencilerin en cok kullandigiuc medya araciolan: Gazete, televizyon ve interneti kullanma bicimleri “kullanimlar ve doyumlar yaklasiminin” perspektifinde ortaya konulmaya calisilmistir. Arastirmaya katilan 205 universite ogrencisine anket uygulanmisve cevaplar SPSS 15.0 programinda analiz edilmistir. Arastirma, cinsiyet ve gelir farkliliklarinin medya izleme aliskanliklariuzerinde onemli tesirlerinin bulundugunu gostermistir.
Time domain analysis for UWB antenna synthesis

In this paper, a time domain analysis for the synthesis of antennas suitable for Ultra-Wideband (UWB) communications is presented. Towards this end, a set of time domain requirements that guarantee good impedance matching, distortionless properties, and omnidirectional radiation characteristics are defined. In order to find an antenna configuration fitting these requirements, the structure of the antenna is defined by means of a spline-based geometry. The synthesis problem is then recast as an optimization problem aimed at finding the best values of the antenna descriptive parameters. The effectiveness of the proposed approach is assessed by showing a preliminary and representative result.
Sewing Worlds Together With SEAMs: A Mechanism to Construct Complex Virtual Environments

This paper introduces the Spatially Extended Anchoring Mechanism (SEAM) as a 3-D user-interface metaphor to connect virtual worlds and manage scalability in distributed virtual environments. SEAMs provide a visual and navigable connection between worlds to manage both the complexity of rendering and network communication typically occurring in such environments. In the context of augmented reality, SEAMs can be applied as a 3-D window interface. A rendering algorithm is described which performs well on the graphics accelerators of standard personal computers.
Defining the complexity of childhood obesity and related behaviours within the family environment using structural equation modelling

Abstract Objective The present study aimed to define the complexity of the relationships between the family environment, health behaviours and obesity. A conceptual model that quantifies the relationships and interactions between parent factors, family environment, and certain aspects of children's behaviour and weight status is presented. Design Exploratory structural equation modelling was used to quantitatively model the relationships between parent, child and family environmental factors. Setting Adelaide, South Australia. Subjects Families (n 157) with children aged 5–10 years completed self-reported questionnaires, providing data on parents’ knowledge, diet quality and activity habits; child feeding and general parenting styles; and the food and physical activity environments. Outcome variables included children's fruit and vegetable intake, activity and sedentary habits and weight status. Results The proposed model was an acceptable fit (normed fit index = 0·457; comparative fit index = 0·746; root-mean-squared error associated = 0·044). Parents’ BMI (β = 0·32) and nutrition and physical activity knowledge (β = 0·17) had the strongest direct associations with children's BMI Z-score. Parents’ dietary intake and energy expenditure behaviours were indirectly associated with children's behaviour through the creation of the home environment. The physical activity and food environments were associated with children's sedentary (β = −0·44) and activity habits (β = 0·29), and fruit and vegetable intake (β = 0·47), respectively. Conclusions A conceptual model that quantifies the complex network of family environment factors influencing children's behaviour and weight status is presented. The model provides a basis for future research on larger representative samples with a view to guiding obesity prevention interventions.
Bardo: Emotion-Based Music Recommendation for Tabletop Role-Playing Games

In this paper we introduce Bardo, a real-time intelligent system to automatically select the background music for tabletop role-playing games. Bardo uses an off-the-shelf speech recognition system to transform into text what the players say during a game session, and a supervised learning algorithm to classify the text into an emotion. Bardo then selects and plays as background music a song representing the classified emotion. We evaluate Bardo with a Dungeons and Dragons (D&D) campaign available on YouTube. Accuracy experiments show that a simple Naive Bayes classifier is able to obtain good prediction accuracy in our classification task. A user study in which people evaluated edited versions of the D&D videos suggests that Bardo's selections can be better than those used in the original videos of the campaign.