Miracle-dz/UniFAR-FTUs huggingface dataset:
Safety of drug-coated stents

Background: Drug-coated (i.e., drug-eluting) stents (DES) are frequently used nowadays in the treatment of coronary artery disease given their superior antirestenotic effect and clear benefits in terms of reduction of repeat revascularizations and major adverse cardiac events. However, a number of safety concerns have been raised on DES. Objective: To appraise current data on the safety of DES. Methods: A thorough PubMed search was done for pertinent clinical reports on DES safety with the following string (updated December 2007): (drug* OR sirolimus OR paclitaxel) AND eluting* AND stent* AND (safety OR complication* OR thrombos* OR infarction) NOT (editorial[pt] OR review[pt]). Results/conclusion: A total of 1077 citations were retrieved and appraised. The most relevant threats to DES safety were bleeding, difficulties in balloon deflation and retrieval, endothelial dysfunction and vasospasm, hypersensitivity, infection, late acquired malapposition and aneurysm formation, late restenosis, peri-procedural myocardial infarction, plaque prolapse, stent dislodgement or embolization, stent fracture, and stent thrombosis (with ensuing risk of death, myocardial infarction or arrhythmia). Of these, the most important and debated safety issue is the potentially increased risk in late stent thrombosis, which might offset the antirestenotic benefits of DES especially in patients at higher risk of thrombosis or who cannot comply with the recommended dual antiplatelet regimen. Nonetheless, further clinical studies are warranted to clarify whether these safety threats should be a concern for the large target population of patients with coronary artery disease most likely to benefit from DES implantation.
A real sense based multilevel security in cloud framework using face recognition and image processing

A 3D image can be used for the authentications as it gives more accuracy. We can also use the gestures for the authentication purpose. We can add multiple authentication levels together to make system more secure and login process more reliable. In our system we are going to provide three levels of authentication i.e. 1) Text Password:-This is first level in which user has to enter the text password which is OTP. OTP will be sent to the registered email-id or at the mobile number given. With The help of AES (advance encryption standard) algorithm the data will be encrypt and store at database server.2) Hand Gesture Recognition:-This is second level in which user has to place this hand in front of camera. So camera can detect it, select one point out of 22 points on the hand whatever pattern user make in front of camera is saved as password at user's database. 3) Face Recognition:-This is last level in which user has to place face in front of camera. So camera can detect the face and select 78 landmark points. And those points are saved at the user's database. After passing all these stages user is authenticate and can upload or download the documents of his/her choice.
Sequential design and analysis of dose finding studies in patients with life threatening disease

Summary— We describe a recently developed approach to the design and analysis of dose finding studies in patients with life‐threatening disease. Such patients may be terminally ill and, although interest is focussed on cancer, the methodology is more generally applicable. Of major interest is the identification of a dose with a given targeted toxicity level. Experimentation is carried out at a level for which all current available evidence, ie any information available before beginning the study, typically used in determining dose levels, together with information accumulated in the course of the study, indicates the best estimate of the target level. At the end of the study it is possible to obtain a statistical estimate of the probability of toxicity at the chosen level. Note that such estimation is not possible after a dose finding study carried out along traditional lines.
Analysis of arsenic bioavailability in contaminated soils

The bioavailable arsenic (As) content of contaminated soils was determined by joint analyses of acid‐soluble, total water‐soluble, and biovailable As by using a luminescent bacterial sensor, Escherichia coli MC1061(pTOO31). According to the results of this study, a significant positive correlation was found between the concentration of total water‐soluble As and the bioavailability of As. However, the bioavailability of As in soil varied between sampling sites and was not equal when compared to the concentration of total water‐soluble As; bioavailable As was 3 to 77% of total water‐soluble As in soil. Our experiments also showed that aging and sequestration of As occurs in contaminated soils and As compounds thus become progressively less bioavailable with time. As a consequence, the bioavailability and toxicity of As should be considered when evaluating the ecological risks of contaminated soils.
Preparation of poly (alkylcyanoacrylate) nanoparticles by polymerization of water-free microemulsions

Phase diagrams of the pseudoternary systems ethyloleate, polyoxyethylene 20 sorbitan mono-oleate/sorbitan monolaurate and propylene glycol with and without butanol as a co-surfactant were prepared. Areas containing optically isotropic, one-phase systems were identified and samples therein designated as droplet, bicontinuous or solution type microemulsions using conductivity, viscosity and self-diffusion NMR. Nanoparticles were prepared by polymerization of selected microemulsions with ethyl-2-cyanoacrylate and the morphology of the particles was investigated. Addition of monomer to all types of microemulsions led to the formation of nanoparticles, which had an average size of 244 ± 25 nm, an average polydispersity index of 0.15 ± 0.04 and a zeta-potential of −17 ± 3 mV. The formation of particles from water-free microemulsions of different types is surprising, particularly considering that polymerization is expected to occur at a water–oil interface by base-catalysed polymerization. It would appear that propylene glycol is sufficiently nucleophilic to initiate the polymerization. The use of water-free microemulsions as templates for the preparation of poly (alkylcyanoacrylate) nanoparticles opens up interesting opportunities for the encapsulation of bioactives which do not have suitable properties for encapsulation on the basis of water-containing microemulsions.
On the Comprehensive Parametrization of the Photovoltaic (PV) Cells and Modules

In the classical parametrization of the single-diode model of photovoltaic (PV) cells and modules based on the datasheet values, first, the values of the five unknown parameters of the PV model are extracted via the values of the open-circuit voltage Voc, the short-circuit current Isc, and the voltage and current at the maximum power point Vm, Im at standard test conditions (STC). Next, using some translational formulas, the STC values of the unknown parameters are projected to the new climatic conditions other than STC. A major problem of this approach is to determine the translational formulas of the five unknown parameters of the single-diode model as a function of both temperature and irradiation levels with a high degree of accuracy beforehand. This paper presents a new method to extract the parameters of the PV model that operates with a reverse identification process, as compared with the classical methods, in the sense that it starts with the translational formulas of the key parameters of Voc, Isc, Vm, and Im and yields the variation of the all PV model unknown parameters as a function of both temperature and irradiation levels. The satisfactory operation of the proposed parametrization technique is evaluated by simulations, experiments, and comparative studies with the classical methods.
Morphological Analysis of 3D Faces for Weight Gain Assessment

In this paper we analyse patterns in face shape variation due to weight gain. We propose the use of persistent homology descriptors to get geometric and topological information about the configuration of anthropometric 3D face landmarks. In this way, evaluating face changes boils down to comparing the descriptors computed on 3D face scans taken at different times. By applying dimensionality reduction techniques to the dissimilarity matrix of descriptors, we get a shape space in which each face is a point and face shape variations are encoded as trajectories in that space. Our first results show that persistent homology is able to identify features which are well-related to overweight, and may help assessing individual weight trends. The research is carried out in the context of the European project SEMEOTICONS, which is developing a multisensory platform which detects and monitors over time facial signs of cardio-metabolic risk.
An Improved Method of Traffic Forecasting Based on Tariff-SASVR

Traffic forecasting is critical for mobile operators to grasp market trends and control network capacity. Therefore, an improved method of forecasting for mobile traffic is presented in this paper. The traffic is divided into the general trend part and seasonal part to forecast them respectively. The general trend is predicted by fitting the curve of general trend on tariff level; and the remaining seasonal part is predicted by simulated annealing-support vector regression machine (SASVR) which uses simulated annealing (SA) to select the super-parameters of SVR. The experimental results show that not only this method improves the prediction accuracy but it provides mobile operators with a visual expression of the relationship between traffic and the tariff level.
Provisional chapter Speaker Recognition : Advancements and Challenges

Speaker Recognition is a multi-disciplinary branch of biometrics that may be used for identification, verification, and classification of individual speakers, with the capability of tracking, detection, and segmentation by extension. Recently, a comprehensive book on all aspects of speaker recognition was published [1]. Therefore, here we are not concerned with details of the standard modeling which is and has been used for the recognition task. In contrast, we present a review of the most recent literature and briefly visit the latest techniques which are being deployed in the various branches of this technology.
Rugged terrain segmentation based on salient features

In the last decade significant progress in computer vision based control of unmanned ground vehicles (UGV) has been achieved. However, until now textural information has been somewhat less effective than color or laser range information. In this paper we propose a computer vision based cross country segmentation system that is capable of distinguishing cross-country road, grass and trees during day-time and night times. For this purpose we extract Speeded-Up Robust Features (SURF) from the training image set and construct texture class models using two-layer feed-forward neural network. Using these constructed models and extracted features from the images captured by the CCD and IR cameras we estimate features' class membership values. These estimated values and features' spatial positions are then applied for image segmentation. A number of experiments are conducted with the lowest mean error segmentation rate of 16.78% and 20.60% for images in IR and visible spectrum correspondingly.
Bidirectional Trafficking of Membrane Glycoproteins following Platelet Activation in Suspension

ma membrane permits platelets to interact with leukocytes at sites of vessel injury (10). The fact that many membrane glycoproteins are common to the plasma membrane, SCCS and granule membranes (13), also means that secretion can lead to an increased number of receptors at the platelet surface. Yet, parallel alternative pathways clear surface receptors to the internal membrane systems of platelets and this is how the concept of "bidirectional trafficking" has been brought about. The laffer process has been reported for GP Ib-X-V complexes and ligand-bound GP IIb-IIIa complexes. It has been implied to be pafi of a down-regulation mechanism for the seven transmembrane domain thrombin receptor (14). Fig. I summarizes some of the events that form the basis of this review as I focalize on the movements of membrane glycoproteins within the membrane systems of platelets activated in suspension. Platelet adhesion and aggregation involve membrane glycoproteins (GPs) that act as specific receptors for ligands mediating platelet-extra-cellular matrix or platelet-platelet interactions (1). Thg fact that platelets circulate without adhering to each other or to the undamaged vessel wall results from the special properties that govern the interactions between the receptors and their ligands. Adhesion transforms circulating platelets into immobilized cells attached to subendothelial compo-nents. GP h-IX complexes promote adhesion by binding to von Willebrand factor (vWF), yet vWF multimers in plasma do not, in a normal situation, express the conformation recognized by the receptor. To acquire this conformation
Recent developments in solution x-ray scattering.

We are concerned here with the structural information that it is possible to retrieve from the X-ray scattering study of macromolecules in solu­ tion. The general law governing X-ray scattering phenomena expresses the angular dependence of the scattered intensity as a function of the space distribution of the interatomic distances in the scatterer and of the nature of the atoms involved. When the scatterer is isotropic, the intensity is a function only of the moduli of the interatomic vectors, not of their orientation. Let r]J(r) be this isotropic distribution of the interatomic distances (a precise definition is given below). For a dilute solution of macromolecules the functionp(r) can be expected to display sharp short-range fluctuations (1 to 5 A) corresponding to pairs of neighboring atoms, followed by more damped fluctuations if middle­ range regularities are present-for example in the 5 to 10 A region for a-helical proteins. Beyond approximately 10 A. the number and variety of the interatomic vectors increases very rapidly with increasing r, and the function per) gradually smoothes out and slowly decreases. When r exceeds the maximal dimensions of the macromolecule, per) becomes uniform, since all the vectors involve only the solvent. Because the scattered intensity i(s) and the distribution p(r) are related by a Fourier transformation, such a separation of the fluctua­ tions of per) into two classes entails the presence in ;(s) of two distinct regions. One, at s small, contains the information relevant to the long-range (macromolecular) organization; the other, at s large, mirrors
Fuzzy Clustering for Data Time Arrays With Inlier and Outlier Time Trajectories

In many knowledge discovery and data mining tasks, fuzzy clustering is one of the most common tools for data partitioning. In this paper dynamic fuzzy clustering models for classifying a set of multivariate time trajectories (time series, sequences) are developed. In particular, by adopting an exploratory approach, based on a geometric-algebraic formulation of the data time array, different kinds of dynamic fuzzy clustering models, based on cross sectional and longitudinal aspects, are suggested. Furthermore, a modified version of the previous clustering models, that can be seen as a generalization of these models, is proposed. By utilizing these models we can obtain beneficial effects in the clustering process when anomalous trajectories (trajectories with anomalous positions and slopes) are present in the dataset; in fact the models are suitable for detecting structures of time trajectories with anomalous patterns that are not uniformly distributed over the structure's domains and are characterized by strange slopes. In these models, the disruptive effect of the anomalous trajectories is neutralized and smoothed and the information on the influence of individual time trajectories on the detected groups is given. Furthermore, some remarks on dynamic three-way extensions of a few robust fuzzy clustering models for two-way data are suggested. Demonstrative examples are shown and a comparison assessment based on artificial multivariate time-varying data is carried out
Generalized anxiety disorder and its comorbidities: disputes at the boundaries

This theoretical paper reviews the status of generalized anxiety disorder (GAD) and the Axis I and Axis II disorders with which it is often comorbid. Differences in comorbidity between the epidemiological and clinical literatures are discussed. Special attention is given to panic disorder, the symptoms of which are similar to those of GAD. The boundaries of GAD and its relationship to other Axis I disorders and to Axis II disorders raise important implications for its classification.
The impact of a literature consult service on geriatric clinical care and training in falls prevention.

The importance of developing effective health care programs and services for elderly persons in the United States is increasing at warp speed due to significant projected growth in the size of this demographic in the near future. According to the US Census Bureau, the number of persons aged 65 years and older is expected to rise from an estimated 35 million people in 2000 to 55 million by the year 2020 [1]. The rapid growth in this age group can be explained in part by a considerable rise in the number of older people projected for 2011, when the Baby Boom generation (persons born between 1946 and 1964) begins to turn 65 years old. The number of oldest old (persons aged 85 years and older) is projected to double from 4.7 million in 2003 to 9.6 million by 2030 [2]. The growth is also partly explained by a steady increase in life expectancy from birth for both men and women, regardless of ethnicity, over the last century, currently at an all-time high of 77.9 years [3], compared to 49.2 years in 1900 [4]. Providing appropriate health care services for this age group is also gaining prominence in the United States [5, 6]. Geriatrics is the branch of medicine that focuses on prevention, diagnosis, and treatment of diseases in the aged and on the socioeconomic matters that affect health care services for elderly persons. Geriatrics research and clinical practice encompass both persons residing with or without caregivers at home and those receiving clinical care at hospitals and nursing facilities [7]. In addition to managing the care of aged patients, the key goals of geriatric medicine include training medical students, physicians, and other health care professionals in geriatric issues as well as researching the aging process and the accompanying conditions affecting the elderly [8]. One of the major issues targeted by geriatric medicine is the prevention of accidental falls [9]. Falls are a common health risk, can occur in virtually any setting, and can be fatal, particularly among individuals sixty-five years and older [10]. Complications due to falls are the leading cause of death due to injury in this age group in the United States. Falls are also one of the primary causes prompting emergency care and hospitalizations among the elderly [10]. These disturbing statistics have brought this issue under significant scrutiny by geriatric clinicians and researchers in medicine.
An updated systematic overview of triple combination therapy in antiretroviral-naive HIV-infected adults

Objective:To compare the effectiveness of three drug combination antiretroviral therapy (ART) in treatment-naive HIV-infected persons, and identify the predictors of responses. Design and methods:Overview of trials identified by searching public domain publications and conference presentations. The three-drug combination therapy was defined as two nucleoside reverse transcriptase inhibitors (NRTI) or nucleotide and NRTI, and either: (1) a protease inhibitor (PI); (2) a non-nucleoside RTI (NNRTI); (3) a third NRTI; or (4) a ritonavir-boosted PI (BPI). Week 24 and 48 results for the proportions of patients with plasma HIV RNA levels < 400 and < 50 copies/ml, and change in CD4+ cell counts were recorded. Results:Fifty-three trials met the entry criteria, and enrolled 14 264 patients into 90 treatment arms. Overall 55% of patients had plasma HIV RNA levels < 50 copies/ml at week 48 and this percentage increased with later publication dates. In unadjusted pairwise comparisons at week 48, significantly greater percentages of patients receiving NNRTI (64%) and BPI (64%) had RNA < 50 copies/ml than NRTI (54%) or PI (43%), and CD4+ cell count increases were significantly greater in the BPI group (+200 cells/μl) than the PI (+179), NNRTI (+173), or NRTI (+161) groups. Pill count and percentage of patients with week 48 plasma HIV RNA levels < 50 copies/ml were correlated in the univariate analysis (P = 0.0053; r = −0.323), but pill count was not a significant predictor in the multivariate analyses. Drug class and baseline CD4+ cell counts were significant predictors, but explained only a modest amount of the treatment effect, (R2 = 0.355). Conclusions:NNRTI and BPI-containing regimens offer superior virologic suppression over 48 weeks, supporting existing guidelines for the choice of initial ART. Pill count was not a consistent predictor of virologic suppression.
Budding and development in Salpa

The life-cycle of Salpa has been the subject of many illvestigations. I t is one of coritiiiual development and change, a story Chamisso (1874) found to be more strange and woiiderful than anything in his own romances arid poetry, a i d a story that no one believed wlieii he reported it. The majority of accounts date between 1870 arid 1890. Since that period three important publications have appeared, Brooks ’ classical monograph (1893) ; a couple of stimulating papers by Johnson (’10) and Ritter and Johnson (’ll), pioneering the way to the mathematical study of growth and form, and a critical reinvestigation by Brien (’28). I t appears there should be little left to do. Yet a brief quotation from Brooks’ own 400-page effort is still applicable, “all my pleasure is destroyed by the thought that nearly everyone of my statements will contradict the published statements of some one among the numerous writers on the subject . the story of the life history of Salpa is most interesting, but is complicated and difficult to tell in simple words even after it has been stripped of all which is not essential . the home of the Salpae is so remote from common observation that few persons . have a true conception of their scientific interest or their importance in the economy of the sea. ” His account which follows these remarks is now classical, but it is not the whole story for the very reasons he himself gives, and much of it is put back in the melting pot by Rrien’s very different conclusions.