Miracle-dz/UniFAR-FTUs huggingface dataset:
Ablation of CBP in Forebrain Principal Neurons Causes Modest Memory and Transcriptional Defects and a Dramatic Reduction of Histone Acetylation But Does Not Affect Cell Viability

Rubinstein-Taybi syndrome (RSTS) is an inheritable disease associated with mutations in the gene encoding the CREB (cAMP response element-binding protein)-binding protein (CBP) and characterized by growth impairment, learning disabilities, and distinctive facial and skeletal features. Studies in mouse models for RSTS first suggested a direct role for CBP and histone acetylation in cognition and memory. Here, we took advantage of the genetic tools for generating mice in which the CBP gene is specifically deleted in postmitotic principal neurons of the forebrain to investigate the consequences of the loss of CBP in the adult brain. In contrast to the conventional CBP knock-out mice, which exhibit very early embryonic lethality, postnatal forebrain-restricted CBP mutants were viable and displayed no overt abnormalities. We identified the dimer of histones H2A and H2B as the preferred substrate of the histone acetyltransferase domain of CBP. Surprisingly, the loss of CBP and subsequent histone hypoacetylation had a very modest impact in the expression of a number of immediate early genes and did not affect neuronal viability. In addition, the behavioral characterization of these mice dissociated embryonic and postnatal deficits caused by impaired CBP function, narrowed down the anatomical substrate of specific behavioral defects, and confirmed the special sensitivity of object recognition memory to CBP deficiency. Overall, our study provides novel insights into RSTS etiology and clarifies some of the standing questions concerning the role of CBP and histone acetylation in activity-driven gene expression, memory formation, and neurodegeneration.
Comparison antioxidant effect of fennel extract and BHT on the quality of minced silver carp during refrigerated storage

This study evaluated the ability of fennel extract to improve the quality of refrigerated minced silver carp over a period of 16 days. Minced silver carp were treated with fennel extract (0.5, 1 and 1.5% w/w), and beta-hydroxy toluene (BHT 200 ppm). The control and the treated fish samples were analyzed periodically (every­4 days) by chemical analysis (Peroxide value (PV), thiobarbituric acid (TBA) and free fatty acid (FFA). Results showed that the fennel extract and BHT could reduce lipid oxidation in the samples compared to the control. Moreover, minced silver carp treated with 1.5% fennel extract showed the lowest amount of lipid oxidation. The results indicated that fennel extract was improving the quality characteristics of treated fresh minced fish.
Electrospun Polyaniline/Poly(methyl methacrylate)‐Derived Turbostratic Carbon Micro‐/Nanotubes

Nanotubes have great potential for applications in a rapidly increasing range of fields: catalysis, medicine, pharmacy, pheromone-release systems for crop protection, sensorics, and photonics. This is due to their high anisotropy, huge specific surface area that enhances reactivity, high rate of adsorption, and efficiency of transport processes both within and across the nanotube walls. Electrospinning is a process that produces continuous polymer fibers through the action of an external electric field imposed on a polymer solution (for a review of this process see previous publications). To manufacture nanotubes, two fundamentally different approaches have been reported: self-assembly and template-based methods. In the TUFT (tubes by fiber templates) process, electrospun nanofibers themselves are used as templates to produce nanotubes. The template-based TUFT process for nanotube production consists of three stages: i) the electrospinning of template nanofibers, ii) shell deposition via chemical or physical vapor deposition (CVD or PVD, respectively), and iii) core removal by thermal or chemical means. Recently, a new technique was introduced that allows the co-electrospinning of polymer solutions from a spinneret containing two coaxial capillaries. Using this technique, coelectrospinning of immiscible and miscible pairs of polymer solutions produced nanofibers with core/shell structures. This technique was then used to co-electrospin conjugated polymer nanofibers and to make the PCL/gelatin (PCL: poly(e-caprolactone)) core/shell structure that holds great potential for controlled drug delivery and as a scaffold for tissue engineering. It was possible to co-electrospin almost non-spinnable polymers such as the conducting polymer polyaniline (PAni). Using this same co-electrospinning technique, ceramic sol–gel precursors were added to the shell solutions to create ceramic nanotubes. The core material—a heavy mineral oil—was later extracted with octane. The aim of the present work is to produce hollow carbon nanotubes by co-electrospinning two polymer solutions. The process was carried out in two stages. In the first stage, use was made of the non-solvent effect on one of the polymers to facilitate the creation of a solid interface between the nanofiber’s core and shell. In the second stage, the nanofibers were subjected to heat treatment to degrade the core polymer and carbonize the polymer shell. Figure 1 shows a typical pattern of the co-electrospinning process close to the core/shell spinneret. The core-polymer capillary protrudes 0.3 to 1 mm below the shell capillary. As
Review of the anisotropy working group at UHECR-2012

The study of ultra-high energy cosmic rays (UHECRs) has recently experienced a jump in statistics as well as improved instrumentation. This has allowed a better sensitivity in searching for anisotropies in the arrival directions of cosmic rays. In this written version of the presentation given by the inter-collaborative "Anisotropy Working Group" at the International Symposium on Future Directions in UHECR physics at CERN in February 2012, we report on the current status for anisotropy searches in the arrival directions of UHECRs.
USER PRIVACY SELECTION CRITERIA ON PERSONAL DATA IN PUBLIC NETS

A lot of the content discussing websites will grant users to get in the privacy preferences. Our tasks are linked to works based on privacy configuration within crack houses, recommendation systems, additionally to privacy analysis of internet images. We advise an adaptive privacy conjecture system to assist users make privacy settings meant for their images and check out social context, image content, additionally to metadata as achievable indicators of user privacy preference. The recommended plan will handle images of user posted, additionally to factors that influence privacy settings of images for instance impact of social setting additionally to non-public characteristics and role of image content additionally to metadata. The forecasted system will give you comprehensive structure to infer privacy preferences on first step toward information available for any specified user and includes two primary building for instance Adaptive Privacy Conjecture-Social additionally to Core. Adaptive privacy conjecture core will spotlight on analyzing of each and every individual user own images additionally to metadata, while adaptive privacy conjecture-social can have a residential district perspective of privacy techniques for user privacy enhancement.
Ruttonsha The Many Faces of Design From Adaptive Response to Creative Agency to Emergent Engagement

In light of contemporary global pressures, designers have been considering how to apply their thinking and practice more broadly within the enterprise of sustainability. Given the often wicked nature and cross-scale dynamics of related challenges, there is reason to reassess the role of design in processes of systems transformation amidst complexity. In this manuscript, the author contemplates the diversity of ‘designerly ways’, in interpretation of designers’ encounters with complex adaptive systems. These interactions are classified here using the three lenses of adaptive response, creative agency and emergent engagement.
Out-migration survival of wild Chinook salmon (Oncorhynchus tshawytscha) smolts from Mill Creek through the Sacramento River during drought conditions

Author(s): Notch, Jeremy | Advisor(s): Edwards, Christopher A | Abstract: Once emerged from the gravel after being spawned in natal streams, Chinook salmon spend many months rearing and growing in freshwater before undergoing smoltification and out-migrating to the ocean. This relatively short period of time is considered to be the most vulnerable and dangerous phase in the life cycle of a Pacific salmon. It is during this phase when smolts navigate around many anthropogenic structures and experience environmental stressors while making their way to the ocean. In California’s Central Valley, the few remaining wild populations of Chinook salmon (Oncorhynchus tshawytscha) out-migrate through a highly modified riverine and estuary landscape characterized by leveed banks, altered flow and temperature regimes, transformed food webs, and limited floodplain and rearing habitat. Juvenile salmon smolts migrate through these landscapes within a relatively short period of time, requiring them to quickly adapt to changing water conditions and habitat types. Understanding the survival rates of wild smolts from source tributaries to the Pacific Ocean is essential in protecting and restoring these populations from the low abundances currently observed. When faced with drought conditions out-migrating smolts experience low flows, elevated water temperatures and high densities of predators while out-migrating to sea. In order to assess smolt survival during drought conditions in late spring (April-May), 304 wild smolts were acoustically tagged and tracked from Mill Creek (Tehama County) to the Pacific Ocean between 2013 and 2016. Total outmigration survival to the ocean was 0.3% during these years, with only one fish making it to the Golden Gate and the Pacific Ocean. These survival estimates are some of the lowest ever recorded for salmon out-migrating to the Pacific Ocean, with much of the mortality occurring within Mill Creek and the Sacramento River. Cumulative survival through Mill Creek (rkm 452-441) was 68% (±12 S.E.), and cumulative survival through the Sacramento River (rkm 441-203) was 7.6% (± 16 S.E.) These low survival rates are likely attributed to low flows in Mill Creek and the Sacramento River resulting from critically dry winters between 2013 and 2015, which were reduced even further by water diversions for agriculture in both Mill Creek and the Sacramento River. During periods of higher flow in 2016 survival rates dramatically increased, suggesting that more water in Mill Creek and the Sacramento River is necessary to improve in-river smolt migration survival during the late spring.
An Evaluation of Convolutional Neural Network Models for Object Detection in Images on Low-End Devices

This research paper investigates the running of object detection algorithms on low-end devices to detect individuals in images while leveraging cloud-based services to provide facial veriﬁcation of the individuals detected. The performance of three computer vision object detection algorithms that utilize Convolutional Neural Networks (CNN) are compared: SSD MobileNet, Inception v2 and Tiny YOLO along with three cloud-based facial veriﬁcation services: Kairos, Amazon Web Service Rekognition (AWS) and Microsoft Azure Vision API. The results contribute to the limitations of running CNN based algorithms to solve vision tasks on low-end devices and highlights the limitations of using such devices and models in an application domain such as a home-security solution.
Proposta de Modelo Socioafetivo de Aluno para a Recomendação de Estratégias Pedagógicas

This article presents a proposal of a socio-affective model of the student as one of the elements for the definition of his profile in a system of recommendation of pedagogical strategies. For that, a reassessment of the current affective model of the student is made, a basic element of the Affective Map, a tool available in the virtual learning environment ROODA. At same time, it is need to incorporate into the model some categories of social information inferred by the Social Map. It is understood that socio-affective strategies can help the teacher to improve his/her pedagogical practice, favoring actions that integrate the student distanced or disinterested. Resumo. Este artigo apresenta uma proposta de modelo socioafetivo do aluno como um dos elementos para a definição do seu perfil em um sistema de recomendação de estratégias pedagógicas. Para tanto, é feita uma reavaliação do atual modelo afetivo do aluno, elemento base do Mapa Afetivo, ferramenta disponibilizada no ambiente virtual de aprendizagem ROODA. Da mesma forma, identifica-se a necessidade de incorporar ao modelo algumas categorias de informações sociais inferidas pelo Mapa Social. Entende-se que as estratégias socioafetivas podem auxiliar o professor a aprimorar sua prática pedagógica, favorecendo ações que integrem o aluno distanciado ou desinteressado.
Draft 1 Larval dispersal underlies demographically important inter-system connectivity in a Great Lakes 1 yellow perch ( Perca flavescens ) population 2 3

20 Ability to quantify connectivity among spawning subpopulations and their relative contribution 21 of recruits to the broader population is a critical fisheries management need. By combining 22 microsatellite and age information from larval yellow perch (Perca flavescens) collected in the 23 Lake St. Clair – Detroit River system (SC-DRS) and western Lake Erie with a hydrodynamic 24 backtracking approach, we quantified subpopulation structure, connectivity, and contributions of 25 recruits to the juvenile stage in western Lake Erie during 2006-2007. After finding weak (yet 26 stable) genetic structure between the SC-DRS and two western Lake Erie subpopulations, 27 microsatellites also revealed measurable recruitment of SC-DRS larvae to the juvenile stage in 28 western Lake Erie (17-21% during 2006-2007). Consideration of pre-collection larval dispersal 29 trajectories, using hydrodynamic backtracking, increased estimated contributions to 65% in 2006 30 and 57% in 2007. Our findings highlight the value of complementing subpopulation 31 discrimination methods with hydrodynamic predictions of larval dispersal by revealing the SC32 DRS as a source of recruits to western Lake Erie and also showing that connectivity through 33 larval dispersal can affect the structure and dynamics of large-lake fish populations. 34 35
SYNTHESIS OF 1,3,4-OXADIAZOLE INCORPORATED AZO DYE DERIVATIVES AS A POTENT BIOLOGICAL ACTIVITY MOLECULES

In present study 5,5'-(5-nitrobenzene-1,3-diyl)bis(1,3,4-oxadiazole-2-thiol)azo dye were synthesized by multistep reaction sequences, Structure of newly synthesized compounds characterized and confirmed by IR, NMR and Mass spectral studies. The synthesized compounds were screened for their antimicrobial and in vitro antioxidant properties. Synthesized compounds were found to be potent antibacterial and antioxidant agents. All the synthesized compounds exhibit significant biological activity and are certainly hold greater promise for discovering safer biologically active molecules.
SMART - Sediment Mitigation Actions for the River Rother, UK

Abstract. The River Rother, West Sussex, is suffering from excess sediment which is smothering the river bed gravels. This is thought to be exacerbating issues of pollution and degradation of ecosystems. This project aims to identify the severity, extent, possible causes and potential mitigation options available to reduce these pressures on the river. Data have been collected from ten sites to investigate the amount of sediment stored in the river bed gravels and cores obtained from four small reservoirs to establish rates of sedimentation and contribute to the construction of a temporal sediment budget over the last 50–100 years. Evidence suggests that tributary streams have more stored sediment per m2 upstream of their confluence with the River Rother compared to the Rother itself. Reservoir core data indicate that sediment has accumulated more rapidly in the small reservoirs surrounded by mixed agricultural land compared to one surrounded by ancient woodland. These are preliminary results and work is continuing.
Pulsar current sheet Cerenkov radiation

Plasma-filled pulsar magnetospheres contain thin current sheets wherein the charged particles are accelerated by magnetic reconnections to travel at ultra-relativistic speeds. On the other hand, the plasma frequency of the more regular force-free regions of the magnetosphere rests almost precisely on the upper limit of radio frequencies, with the cyclotron frequency being far higher due to the strong magnetic field. This combination produces a peculiar situation, whereby radio-frequency waves can travel at subluminal speeds without becoming evanescent. The conditions are thus conducive to Cerenkov radiation originating from current sheets, which could plausibly serve as a coherent radio emission mechanism. In this paper we aim to provide a portrait of the relevant processes involved, and show that this mechanism can possibly account for some of the most salient features of the observed radio signals.
Factors influencing the discontinuance in adoption of tissue culture banana technology: a study of smallholder farmers in Maragwa district

iv Abbreviations . vi List of Tables and Figures . vii Table of Content . viii Chapter One . 1 1.0 Introduction . 1 1.1 Background . 2 1.2 Problem Statement . 6 1.3 Objectives and Research Questions . 9 1.4 Justification for the Study . 10 Chapter Two-Literature Review . 12 2.0. Introduction . 12 2.1 Empirical Literature . 12 2.2 Theoretical Literature . 18 2.3 Theoretical Framework: Innovation-Diffusion Theory . 21 2.4 Conceptual Model for this study . 22 Chapter Three . 25 3.0 Research Methodology . 25 3.1 Research Design . 25 3.2 Study site . 25 3.3 Unit of Analysis and Sampling . 27 3.4 Data Sources and Data Collection Methods . 28 3.5 Data Analysis: . 30 Strengths and Limitation of the Study . 30 Chapter Four-Study Findings and Discussion . 32 4.0 Introduction . 32 4.1 Question 1: What are the characteristics of a discontinuing farmer? 32 4.1.1 Characteristics of the tissue culture farmer . 34 4.3 Question 2: What do farmers report as the reasons? 37 4.3.1 Farmer Perception of Tissue Cultured Bananas . 39 4.4 Question 3: What are the advantages of suckers over tissue cultured plantlets? 42 4.4.1 Advantages of Tissue Culture Plantlets . 42 4.4. 2 Disadvantages of Tissue Culture Plantlets . 43
Greener and Sustainable Method for Alkene Epoxidations by Polymer-Supported Mo(VI) Catalysts

A polybenzimidazole supported Mo(VI) (PBI.Mo) catalyst has been prepared and characterised. The catalytic activities of the PBI.Mo catalyst in epoxidation of alkenes with tert-butyl hydroperoxide (TBHP) as an oxidant have been studied under different reaction conditions in a batch reactor. As alkene representatives we have chosen cyclohexene, limonene, ? -pinene and 1-octene (a less reactive terminal alkene). The order of reactivity of the alkenes was found to be: cyclohexene>limonene>? -pinene>1-octene. The stability of each polymer catalyst was assessed by recycling a sample in batch reaction using conditions that will form the basis of the continuous process. The loss of Mo from each support has been investigated by isolating any residue from the reaction supernatant solutions, following removal of the heterogeneous polymer catalyst, and then using the residues as potential catalysts in epoxidation reactions.
Identity and parentage of two alpine grape cultivars from Switzerland ( Vitis vinifera L. Lafnetscha and Himbertscha)

Four closely related white grape cultivars from the Western Alps (Switzerland) - Humagne Blanc, Completer, Lafnetscha and Himbertscha - and three putative relatives or synonyms - Gouais Blanc, Plantscher and Bordeaux Blanc - were analyzed with up to 50 microsatellite markers. Humagne Blanc and Completer are ancient cultivars from the Haut-Valais and Graubunden regions, respectively. Lafnetscha and Himbertscha are lesser-known cultivars scarcely cultivated in Haut-Valais. Lafnetscha is frequently considered as synonym of Completer. Himbertscha might be related to Gouais Blanc, one of the parents of Chardonnay, Gamay, etc. Plantscher, a putative synonym of Lafnetscha, is scarcely cultivated in Haut-Valais (Switzerland) and Bordeaux Blanc (or Gros Bourgogne) is a cultivar of unknown origin (despite its names) cultivated in Switzerland. Our results allowed us to determine the true-to-type Lafnetscha and confirmed that Lafnetscha is not a synonym of Completer. Plantscher is not a synonym of Lafnetscha but a synonym of Bordeaux Blanc (or Gros Bourgogne) and is a likely parent or progeny of the Hungarian Furmint. Himbertscha is not related to Gouais Blanc and shares at least one allele at each locus with Humagne Blanc, providing strong evidence of a parent/progeny relationship. Given that Humagne Blanc is an older cultivar, we propose that it is the parent of Himbertscha. Alleles at 49 out of 50 microsatellite loci are consistent with Lafnetscha being the progeny of Completer and Humagne Blanc. The exception is a 10-base pair discrepancy at one locus (VVMD 36), most likely due to the occurrence of a null allele, since this parentage is supported at other markers by very high likelihood ratios. With Lafnetscha = Completer x Humagne Blanc, we present the second grape cultivar parentage showing a multiple repeat discrepancy at one locus. This study emphasizes that one multiple repeat unit discrepancy is not sufficient to reject a parentage, and that the greater is the number of loci, the greater are the chances to encounter null alleles or clonal mutations.
VIRTUAL INTEGRATED DESIGN AND CONSTRUCTION

Recent surveys in the construction industry (e.g. Egan Report (1)) show that significant value improvement and cost reduction can be gained by substantially integrated solutions being applied by project teams as a mean of reengineering the project process. In particular, these surveys show that there are considerable benefits to be gained by integration of the "design" and "construction" processes. After a brief presentation of potential applications of Virtual Reality (VR) in the construction industry, the paper will focus on the issue of "collaborative virtual prototyping". In particular, the research carried out in the frame of the CAVALCADE 1 project, funded under the European ESPRIT programme (HPCN 2 domain), will be presented. Special emphasis will be put on the concurrent engineering features of CAVALCADE allowing project teams, based in geographically distant locations, to collaboratively design, test and validate shared virtual prototypes. As a conclusion, the objectives of new IST project (DIVERCITY 3 - Distributed Virtual Workspace for enhancing Communication within the Construction Industry) that will build, among others, on the results of CAVALCADE, will then be presented.
Improvement in performance of cascaded multilevel inverter using triangular and trapezoidal triangular multi carrier SVPWM

In this paper a new Trapezoidal Triangular Multi Carrier SVPWM (TTMC-SVPWM) technique has been proposed for a cascaded H bridge multilevel inverter. This technique has been implemented for a 11-level cascaded H-bridge multilevel inverter to evaluate the performance parameters and also to compare it with other types of carrier based PWM techniques such as Phase Disposition (PD), Phase Opposition Disposition (POD), Alternative Phase Opposition Disposition (APOD) and Phase Shifted Carrier (PSC) PWM techniques. The simulation has been carried out for 11-level H-bridge multilevel inverter using MATLAB/Simulink. The detailed analysis of the results has been presented and studied in terms of fundamental component of output voltage and THD.