Miracle-dz/UniFAR-FTUs huggingface dataset:
Gaussian curvature–driven direction of cell fate toward osteogenesis with triply periodic minimal surface scaffolds

Significance This article reports an exciting breakthrough in the translation of the biomimicking hyperboloidal structure into three-dimensional tissue-engineered bone grafts and reveals how the nature-derived hyperboloid structure affects osteogenesis and angiogenesis for expedited bone regeneration. We fabricated triply periodic minimal surfaces (TPMSs) embodied with hyperboloidal topography with different Gaussian curvatures. The wavy TPMS scaffolds directed the osteogenic differentiation and angiogenic paracrine of mesenchymal stem cells through the hyperboloidal topography-induced cytoskeleton reorganization and nuclear deformation, accelerating bone regeneration. We believe that these features can grant our scaffolds application as simple, safe, efficient, and personalized bone grafts with notable clinical translation potential.
Cosmic-ray-induced dissociation and reactions in warm interstellar ices

Context. Cosmic ray particles that hit interstellar grains in dark molecular cores may induce whole-grain heating. The high temperature of a CR-heated grain allows energy barriers for bulk diffusion and reactions to be overcome. Additionally, ice molecules are destroyed by direct cosmic-ray induced dissociation. Aims. We provide a justified estimate of the significance of cosmic-ray induced surface-mantle diffusion, chemical reactions in ice, and dissociation of ice species in a star-forming interstellar cloud core. Methods. We considered a gas clump in a collapsing low-mass prestellar core and during the initial stages of protostellar envelope heating with a three-phase chemical kinetics model. The model includes a proper treatment of the stochastic aspect of whole-grain heating and new experimental data for dissociation. Results. We found that the cosmic-ray-induced effects are mostly limited to an increase in abundance for carbon-chain species. The effect on major species abundances is a few percentage points at most. The HNC to HCN ice abundance ratio in ice is increased. Conclusions. Among the processes considered in the model, dissociation is probably the most significant, while diffusion and reactions on warm grains are less important. All three processes facilitate the synthesis of complex molecules, including organic species.
The Relationship Between Defenses and Learning

Abstract This study investigates the relationship among defense styles and learning through academic procrastination and psychological well-being. The sample comprises 628 social science students from a Greek university. Path analysis is used to explore associations and interactions among the variables. The results show that academic procrastination and psychological well-being mediate the relationship between defense styles and approaches to learning, indicating the expected direct and indirect effects. Defense styles are directly related to approaches to learning. Mature defense styles are associated with learning through psychological well-being in a positive way, and immature defense styles are associated with learning through academic procrastination in a negative way. This study supports the current line of research in associations between defense styles and learning and the importance of linking mental health variables with learning.
Modulated trapping of interacting bosons in one dimension

We investigate the response of harmonically confined bosons with contact interactions (trapped Lieb-Liniger gas) to modulations of the trapping strength. We explain the structure of resonances at a series of driving frequencies, where size oscillations and energy grow exponentially. For strong interactions (Tonks-Girardeau gas), we show the effect of resonant driving on the bosonic momentum distribution. The treatment is `exact' for zero and infinite interactions, where the dynamics is captured by a single-variable ordinary differential equation. For finite interactions the system is no longer exactly solvable. For weak interactions, we show how interactions modify the resonant behavior for weak and strong driving, using a variational approximation which adds interactions to the single-variable description in a controlled way.
Adolescents’ Flexibility Can Affect Motor Competence: The Pathway from Health Related Physical Fitness to Motor Competence

Motor competence has been shown to predict health-related physical fitness (HRPF) components in youth, but there is indeterminate evidence for the reverse path. Even less is known about the specific relationship between motor competence and flexibility. Our aims in this study were to analyze the relationship between flexibility and motor competence among adolescents; and, secondarily, to examine the relationships between motor competence and other HRPF components (body composition and musculoskeletal fitness). We conducted a longitudinal study (14-months follow-up) with two measurement points of 128 participants (55.5% girls; 45% boys) aged 12–13 years at baseline. We assessed HRPF components at the first time point and determined motor competence at the second time point. We assessed HRPF in terms of body composition (body fat percentage), musculoskeletal fitness (sit-up test), and flexibility (sit and reach). We determined motor competence using the Körperkoordinationstest für Kinder (KTK). We employed multivariate analyses of variance (MANOVA) to examine the effect of HRPF on motor competence through three models, in which each HRPF component was considered an independent variable. Sex, age, physical activity, and body mass index (BMI) z-scores were considered confounders. In our crude models all HRPF components significantly affected motor competence. In adjusted models, flexibility (p = .002) and body composition (p < .001) significantly affected motor competence. Overall, these results supported the assumptions that HRPF components are related to motor competence in adolescence, and that flexibility can affect motor competence in young people.
Bloch oscillations in atom interferometry

In Paris, we are using an atom interferometer to precisely measure the recoil velocity of an atom that absorbs a photon. In order to reach a high sensitivity, many recoils are transferred to atoms using the Bloch oscillations technique. In this lecture, I will present in details this technique and its application to high precision measurement. I will especially describe in details how this method allows us to perform an atom recoil measurement at the level of $1.3 \times 10^{-9}$. This measurement is used in the most precise determination of the fine structure constant that is independent of quantum electrodynamics.
Ribosome-bound Upf1 forms distinct 80S complexes and conducts mRNA surveillance

Upf1, Upf2, and Upf3, the central regulators of nonsense-mediated mRNA decay (NMD), appear to exercise their NMD functions while bound to elongating ribosomes, and evidence for this conclusion is particularly compelling for Upf1. Hence, we used selective profiling of yeast Upf1:ribosome association to define that step in greater detail, understand whether the nature of the mRNA being translated influences Upf1:80S interaction, and elucidate the functions of ribosome-associated Upf1. Our approach has allowed us to clarify the timing and specificity of Upf1 association with translating ribosomes, obtain evidence for a Upf1 mRNA surveillance function that precedes the activation of NMD, identify a unique ribosome state that generates 37–43 nt ribosome footprints whose accumulation is dependent on Upf1's ATPase activity, and demonstrate that a mutated form of Upf1 can interfere with normal translation termination and ribosome release. In addition, our results strongly support the existence of at least two distinct functional Upf1 complexes in the NMD pathway.
Delphi survey on the application of advanced practice nursing competencies: Strong points and unfinished business in cancer care

Abstract Aim This study assessed the application of advanced practice nursing competencies in cancer care to identify obstacles to their full implementation. Background Internationally, the implementation of advanced practice nursing roles depends on the context and environment, which shape the definition, scope and competencies associated with these roles. Methods Nurses participated in two rounds of an online Delphi survey about the competencies of advanced practice oncology nurses. The threshold for expert consensus was set at 75%. Results Eleven competency domains were proposed; all yielded consensus of over 75%. However, for 57.8% of the specific competencies proposed in round 1 and for 62.2% in round 2, there was no consensus on which were applied in practice. There was more agreement on the competencies applied in the domains of direct clinical practice, consultation and collaboration and interprofessional relations than in dimensions such as health care promotion, quality improvement, evidence‐based practice and research. Barriers related to unimplemented competencies were identified. Conclusions The competencies applied in advanced practice nursing reflect incomplete development of these roles. Domains related to direct clinical practice, consultation and collaboration and interprofessional relations are relatively well developed, whereas those related to leadership, research, evidence‐based practice and quality improvement are not. The identified barriers hindering implementation of some competencies can inform strategies to develop this role in cancer care. Implications for Nursing Management Hospital administrators and nurse managers should reflect and be mindful of the development of advanced practice nurse (APN) competencies along with the challenges associated with implementing advanced practice roles.
Identification of Overlapping Communities by Locally Calculating Community-Changing Resolution Levels

An algorithm for the detection of overlapping natural communities in networks was proposed by Lancichinetti, Fortunato, and Kertesz (LFK) last year. The LFK algorithm constructs natural communities of (in principle) all nodes of a graph by maximising the local fitness of communities. The resulting modules can overlap. The generation of communities can easily be repeated for many values of resolution; thus allowing different views on the network at different resolutions. We implemented the main idea of the LFK algorithm---to generate natural communities of each node of a network---in a different way. We start with a value of the resolution parameter that is high enough for each node to be its own natural community. As soon as the resolution is reduced, each node acquires other nodes as members of its community, i.e. natural communities grow. For each community found at a certain resolution level we calculate the next lower resolution where a node is added. After adding a node to a community of a seed node we check whether it is also the natural community of a node that we have already analysed. In this case, we can stop expanding the seed node's community. We tested our algorithm on a small benchmark graph and on a network of about 500 papers in information science (weighted with the Salton index of bibliographic coupling). In our tests, this approach results in characteristic ranges of resolution where a large resolution change does not lead to a growth of the natural community. Such stable modules were also obtained by applying the LFK algorithm but since we determine communities for all resolution values in one run, our approach is faster than the LFK reference. And our algorithm reveals the hierarchical structure of the graph more easily.
A Phage Cocktail To Control Surface Colonization by Proteus mirabilis in Catheter-Associated Urinary Tract Infections

The rapid spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) bacterial strains and biofilm formation of bacteria have severely restricted the use of antibiotics and become a challenging issue in hospitals. Therefore, there is a necessity for alternative or complementary treatment measures, such as the use of virulent bacteriophages (phages), as effective therapeutic strategies. ABSTRACT Proteus mirabilis is a biofilm-forming bacterium and one of the most common causes of catheter-associated urinary tract infections (CAUTIs). The rapid spread of multidrug-resistant P. mirabilis represents a severe threat to management of nosocomial infections. This study aimed to isolate a potent phage cocktail and assess its potential to control urinary tract infections caused by biofilm-forming P. mirabilis. Two lytic phages, Isf-Pm1 and Isf-Pm2, were isolated and characterized by proteome analysis, transmission electron microscopy, and whole-genome sequencing. The host range and effect of the phage cocktail to reduce the biofilm formation were assessed by a cell adhesion assay in Vero cells and a phantom bladder model. The samples treated with the phage cocktail showed a significant reduction (65%) in the biofilm mass. Anti-quorum sensing and quantitative real-time PCR assays were also used to assess the amounts of transcription of genes involved in quorum sensing and biofilm formation. Furthermore, the phage-treated samples showed a downregulation of genes involved in the biofilm formation. In conclusion, these results highlight the efficacy of two isolated phages to control the biofilms produced by P. mirabilis CAUTIs. IMPORTANCE The rapid spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) bacterial strains and biofilm formation of bacteria have severely restricted the use of antibiotics and become a challenging issue in hospitals. Therefore, there is a necessity for alternative or complementary treatment measures, such as the use of virulent bacteriophages (phages), as effective therapeutic strategies.
A complex challenge with unclear improvement: the need for involvement, contextualization and facilitation when managers implement a leadership model

Purpose Management and leadership in health care are described as complex and challenging, and the span of control is known to be a key component in the manager’s job demands. The implementation of change can be a challenge in health care, and managers often have roles as implementation leaders. Little attention has been given to how managers perceive the process of implementation. Thus, this study aims to explore second-line managers’ perceptions of, prerequisites for and experiences from the implementation of changes in their manager’s work conditions. Design/methodology/approach A grounded theory–based qualitative design was used. Data were collected from a purposive sample of nine second-line managers by individual semi-structured interviews. The three stages of initial coding, focus codes and axial coding were used in data analysis. Findings Three thematic areas were identified: engagement, facilitation and achievement. The second-line managers’ descriptions suggest that the change work entails a complex challenge with an unclear result. Involvement, consideration for the context and facilitation are needed to be able to conduct a cohesive implementation process. Originality/value This study findings outline that to succeed when implementing change in complex organizations, it is crucial that managers at different levels are involved in the entire process, and that there are prerequisites established for the facilitation and achievement of goals during the planning, implementation and follow-up.
The Lumbar Artery Perforator Flap in Breast Reconstruction

Summary: The lumbar artery perforator flap is a valuable alternative in breast reconstruction whenever the deep inferior epigastric perforator flap is not feasible because of insufficient or unavailable abdominal tissue. The advantage is the ideal shape and consistency of the flap, in addition to the option to perform a nerve anastomosis with the cluneal nerve. The anatomy is consistent, but there are some technical issues related to the short perforator and difficult surgical exposure in the lower back region. The inclusion of a vascular interposition graft improved the authors’ results and facilitated their technical challenges and final inset of the flap. These videos guide the surgeon through the different steps involved in a breast reconstruction with the lumbar artery perforator flap.
WEAK LENSING MASS RECONSTRUCTION: FLEXION VERSUS SHEAR

Weak gravitational lensing has proven to be a powerful tool to map directly the distribution of dark matter in the universe. The technique, currently used, relies on the accurate measurement of the gravitational shear that corresponds to the first-order distortion of the background galaxy images. More recently, a new technique has been introduced that relies on the accurate measurement of the gravitational flexion that corresponds to the second-order distortion of the background galaxy images. This technique should probe structures on smaller scales than that of shear analysis. The goal of this paper is to compare the ability of shear and flexion to reconstruct the dark matter distribution by taking into account the dispersion in shear and flexion measurements. Our results show that the flexion is less sensitive than shear for constructing the convergence maps on scales that are physically feasible for mapping, meaning that flexion alone should not be used to do convergence map reconstruction, even on small scales.
Incidence of symptomatic Covid‐19 infections in patients with mastocytosis and chronic myeloid leukemia: A comparison with the general Austrian population

The SARS‐COV‐2 (Covid‐19) pandemic has impacted the management of patients with hematologic disorders. In some entities, an increased risk for Covid‐19 infections was reported, whereas others including chronic myeloid leukemia (CML) had a lower mortality. We have analyzed the prevalence of Covid‐19 infections in patients with mastocytosis during the Covid‐19 pandemic in comparison to data from CML patients and the general Austrian population.
Transfusion‐associated hyperkalemia in pediatric population: Analyses for risk factors and recommendations

Transfusion‐associated hyperkalemia (TAH) is a potentially life‐threatening complication of red blood cell (RBC) transfusion. Previously, we reported features of RBC transfusions from 35 pediatric patients (TAH group) who had hyperkalemia with RBC transfusion in one‐year period at four facilities. In this study, we used multivariate analyses and artificial intelligence to compare the TAH group to newly collected control group (non‐TAH group) to identify factors associated with TAH occurrence.
Relationship between anxiety and internet searches before percutaneous ultrasound-guided diagnostic procedures: A prospective cohort study

Invasive procedures guided by ultrasound (US) are part of routine medical diagnostic investigation. The lack of knowledge surrounding the technical aspects of such procedures can lead patients to seek complementary information on the Internet, which may in turn trigger anxiety. However, the intersection between the fields of Radiology and Psychology is poorly studied. Here, we identify the profile of an anxious patient before an US-guided intervention. We prospectively studied 133 patients undergoing image-guided procedures. The State-Trait Anxiety Inventory (STAI) was applied for psychometry. Significantly higher anxiety scores were observed in female patients (p = .001), those who believed they had received inadequate information from their referring physician (p = .006), and in patients who considered online information unreliable or difficult to access (p = .007 and p = .001, respectively). Participants who defined themselves as proactive online reported lower anxiety levels (p = .003).
Graphene to Graphane: The Role of H Frustration in Lattice Contraction

Graphane is a two-dimensional system consisting of a single planar layer of fully saturated (sp$^3$ hybridization) carbon atoms with H atoms attached to them in an alternating pattern (up and down with relation to the plane defined by the carbon atoms). Stable graphane structures were theoretically predicted to exist some years ago and just experimentally realized through hydrogenation of graphene membranes. In this work we have investigated using \textit{ab initio} and reactive molecular dynamics the role of H frustration (breaking the H atoms up and down alternating pattern) in graphane-like structures. Our results show that H frustration significantly contributes to lattice contraction. The dynamical aspects of converting graphene to graphane is also addressed.
Questions concerning fertility preservation during transition in girls with Turner syndrome: review of the literature

Loss of fertility is one of the most important concerns facing Turner syndrome (TS) patients as they transition into adult health care. Due to the limited and rapidly decreasing ovarian reserve, many TS patients require fertility preservation (FP) techniques to preserve their reproductive potential until they are ready to pursue procreation. One has to also remember about the additional risks connected with pregnancy in TS patients. In order to determine the optimal time for introducing FP techniques and decrease the chance of an unnecessary intervention, markers and procedures assessing ovarian reserve have been developed. The exposure to potential cardiovascular complications should be determined before FP to avoid unnecessary procedures in patients with potential contraindications to pregnancy. The aim of the present review is to answer the following three questions important for successful preservation of fertility and safe pregnancy in TS: which markers of ovarian reserve should be used as selection criteria for FP? Which methods of FP are the safest and most effective? Are there any cardiovascular contraindications to FP? For each of those questions, separate literature searches have been conducted. A total of 86 articles have been included in this review: 34 for the first question, 35 for the second, and 17 for the third. Ovarian reserve markers and cardiovascular contraindications to pregnancy should be established before FP; hoverer, there are no unambiguous indicators as to which patients should be disqualified from the FP and more evidence is needed in this subject.
A physical scenario for the high and low X-ray luminosity states in the transitional pulsar PSR J1023+0038

PSR J1023+0038 (J1023) is a binary system hosting a neutron star and a low mass companion. J1023 is the best studied transitional pulsar, alternating a faint eclipsing millisecond radio pulsar state to a brighter X-ray active state. At variance with other Low Mass X-ray binaries, this active state reaches luminosities of only ~$10^{34}$ erg s$^{-1}$, showing strong, fast variability. In the active state, J1023 displays: i) a high state ($L_X\sim7\times10^{33}$ erg s$^{-1}$, 0.3-80 keV) occurring ~80% of the time and during which X-ray pulsations at the neutron star spin period are detected (pulsed fraction ~8%); ii) a low state ($L_X~10^{33}$ erg s$^{-1}$) during which pulsations are not detected (~<3%); and iii) a flaring state during which sporadic flares occur in excess of ~$10^{34}$ erg s$^{-1}$, with no pulsation too. The transition between the high and the low states is very rapid, on a ~10 s timescale. Here we put forward a plausible physical interpretation of the high and low states based on the (fast) transition among the propeller state and the radio pulsar state. We modelled the XMM-Newton spectra of the high, low and radio pulsar states, finding a good agreement with this physical picture.