Miracle-dz/UniFAR-FTUs huggingface dataset:
Test–retest of a phoria adaptation stimulus-induced functional MRI experiment

This study was designed to identify the neural substrates activated during a phoria adaptation task using functional magnetic resonance imaging (MRI) in young adults with normal binocular vision and to test the repeatability of the fMRI measurements for this protocol. The phoria adaptation task consisted of a block protocol of 90 seconds of near visual crossed fixation followed by 90 seconds of far visual uncrossed fixation, repeated three times; the data were collected during two different experimental sessions. Results showed that the oculomotor vermis, cuneus, and primary visual cortex had the greatest functional activity within the regions of interest studied when stimulated by the phoria adaptation task. The oculomotor vermis functional activity had an intraclass correlation coefficient (ICC) of 0.3, whereas the bilateral cuneus and primary visual cortex had good ICC results of greater than 0.6. These results suggest that the sustained visual fixation task described within this study reliably activates the neural substrates of phoria adaptation. This protocol establishes a methodology that can be used in future longitudinal studies investigating therapeutic interventions that may modify phoria adaptation.
Protocol for the process evaluation of the Promoting Activity, Independence and Stability in Early Dementia (PrAISED), following changes required by the COVID-19 pandemic

Introduction The Promoting Activity, Independence and Stability in Early Dementia (PrAISED) randomised controlled trial (RCT) is evaluating a home-based, face-to-face, individually tailored, activity and exercise programme for people living with dementia. Social distancing requirements following the COVID-19 pandemic necessitated rapid changes to intervention delivery. Methods and analysis A mixed-methods process evaluation will investigate how the changes were implemented and the impact that these have on participants’ experience. An implementation study will investigate how the intervention was delivered during the pandemic. A study on the mechanisms of impact and context will investigate how these changes were experienced by the PrAISED participants, their carers and the therapists delivering the intervention. The study will commence in May 2020. Ethics and dissemination The PrAISED RCT and process evaluation have received ethical approval number 18/YH/0059. The PrAISED process evaluation will enable us to understand how distancing and isolation affected participants, their activity and exercise routines and whether the therapy programme could be continued with remote support. This will be valuable both in explaining trial results and also contribute to understanding and designing new ways of delivering home-based services and rehabilitation interventions for people with dementia and their carers. Trial registration number ISRCTN15320670; Pre-results.
Fabrication of Micro Ultrasonic Powder Molding Polypropylene Part with Hydrophobic Patterned Surface

Constructing regular micro-structures with certain geometric characteristics on the surface of the polymer part can obtain some specific functions. Micro ultrasonic powder molding (micro-UPM) is an efficient processing technique for the fabrication of well-filled micro-structured Polypropylene (PP) parts. The micro-structure array on the surface of the core insert was obtained by low speed wire electrical discharge machining (WEDM-LS). PP polymer surfaces with micro-structured patterns were successfully replicated from the core insert surface after micro-UPM. By studying the detailed topography characterizations of micro-structured PP parts, the effects of processing parameters (ultrasonic energy, welding pressure and holding time) on the micro-structured filling show that when PP polymer was formed under the conditions of 1000 J, 115 kPa and 8 s during micro-UPM, well-filled micro-structured parts can be obtained. Besides, without low surface energy coating modification, the water contact angles (WCAs) of micro-structured PP parts increased from 85.3° to 146.8°, indicating that the wettability of the surface can be changed by replicating the micro-structure on PP parts after micro-UPM.
Long noncoding RNA PVT1 promotes tumor cell proliferation, invasion, migration and inhibits apoptosis in oral squamous cell carcinoma by regulating miR-150-5p/GLUT-1

Oral squamous cell carcinoma (OSCC) is a cancer with high morbidity and mortality. Research has demonstrated that long non-coding RNAs (lncRNAs) are critical for tumor initiation and development. In the present study, we aimed to ascertain the functions and potential mechanisms of lncRNA plasmacytoma variant translocation 1 (PVT1) in OSCC. Firstly, we found that the expression of PVT1 was increased in human OSCC tumor tissues and it was related to reduced survival of the patients. Furthermore, miR-150-5p expression was downregulated in OSCC tumor tissues and it was negatively related with PVT1. Moreover, GLUT-1 protein expression was upregulated in human OSCC tumor tissues. In addition, cell proliferation capacity was measured by CCK-8 assay and cell invasion and migration were measured by Transwell assay. PVT1 overexpression promoted cell proliferation, invasion and migration, while these effects were abrogated by PVT1 downregulation. In addition, luciferase gene reporter assay verified the miR-150-5p directly binds with PVT1, which regulates the biological functions of OSCC. Additionally, luciferase gene reporter assay confirmed that GLUT-1 was a target for miR-150-5p. The promotion of cell proliferation, invasion and migration in LV-PVT1-transfected cells was eliminated following miR-150-5p overexpression. Finally, in vivo nude mouse xenograft model further verified that PVT1 knockdown inhibited tumor growth, formation, invasion and migration. According to the results, PVT1 is increased in human OSCC tumor tissues, and is related to the poor prognosis of human OSCC patients. We uncovered a previously unappreciated PVT1/miR-150-5p/GLUT-1 signaling axis that promotes cell proliferation, invasion, migration and inhibits apoptosis in OSCC cell lines and in vivo, which suggests that this axis could be a target for the treatment of OSCC.
sATP-binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cells

Extranodal natural killer (NK)/T cell lymphoma, nasal type (ENKL) is a rare type of non-Hodgkin's lymphoma that is associated with limited effective treatment options and unfavorable survival rate, which is partly the result of multidrug resistance (MDR). The presence of side population (SP) cells-SNK-6/ADM-SP (SSP) cells has been previously used to explore mechanisms of drug resistance. ATP-binding cassette subfamily G member 2 (ABCG2) is a gene involved in MDR and is closely associated with SPs. However, the function of ABCG2 in SSP cells is unclear. The present study verified the high expression of ABCG2 in SSP cells. The IC50 values of doxorubicin, cytarabine, cisplatin, gemcitabine and l-asparaginase were tested to evaluate drug sensitivity in SSP cells with different levels of ABCG2 expression. ABCG2 was identified as a gene promoting in MDR. ABCG2 upregulated cell proliferation, increased clonogenicity, increased invasive ability and decreased apoptosis, in vivo and in vitro, when cells were treated with gemcitabine. To conclude, ABCG2 enhanced MDR and increased the typical biological characteristics associated with cancer cells in SP cells. With further investigation of the ABCG2 gene could have the potential to reverse MDR in ENKL.
An HNSCC syngeneic mouse model for tumor immunology research and preclinical evaluation

The lack of reliable animal models to assess the safety and efficacy of drugs and to explore the underlying molecular mechanisms is one of the most severe impediments in head and neck squamous cell carcinoma (HNSCC) tumor immunology research. The majority of xenograft tumor models established using immunodeficient mice neglect the effects of T cells. To date, to the best of our knowledge, there is no syngeneic tumor model available that reflects the immune microenvironmental features of HNSCC tumors. To solve this issue, the present study used 4-nitroquinoline-1-oxide (4-NQO) to induce squamous cell carcinoma in C57BL/6 mice. Three HNSCC cell lines were then established, and one of these, termed JC1, was selected for further analysis due to its enhanced proliferative ability and tumorigenicity in immunodeficient nude mice. However, none of the 3 cell lines could form tumors in immunocompetent mice. Due to the different tumorigenicities in nude and C57BL/6 mice, the immune system may play an important role in inoculated JC1 tumor progression. Chemical induction was used to establish the tumorigenicity-enhanced cell line, JC1-2, which can form syngeneic tumors in immunocompetent C57BL/6 mice. Next-generation sequencing (NGS) was used to perform the immunogenomic and transcriptomic characterization of the JC1-2 cells. Splenocytes were isolated from C57BL/6 mice and co-cultured with JC1-2 cells to verify the responsiveness of the interferon (IFN)-γ pathway in the JC1-2 cell line. Unlike the majority of syngeneic mouse tumors, the JC1-2-formed tumors resembled 'inflamed tumors' due to the abundancy of immune cells in the tumor microenvironment. Moreover, more intense immune responses were observed in the orthotopic mouse model than in the heterotopic model. Thus, this model could be used to delineate the interactions between HNSCC and lymphocytes, and to validate novel immunotherapy targets.
Integrative taxonomy reveals multiple cryptic speci es within Central American Hylo- myrma FOREL, 1912 (Hymenoptera: Formicidae)

Advances in molecular methodology allow for higherr solution analyses of evolutionary relationships a nd species limits. To clarify species boundaries in the ant ge nus Hylomyrma FOREL, 1912 within Central America, we take an integrative approach to taxonomy, combining data from t housands of nuclear loci (Ultra-Conserved Elements), the mitochondrial gene Cytochrome Oxidase I, and morphologic al traits. We reveal potential cryptic species with in named taxa and two morphologically distinct new species: Hylomyrma montana and H. plumosa. Hylomyrma montana is the first definitive montane species in the genus, with popul ations in Costa Rica, Panama, and the Pacific slope o f Ecuador. We show that the Ecuadorian and Central American popul ations form a single clade and are not the result o f convergent, montane specialization. We discuss our findings in rel ation to both montane diversification and Neotropic al biogeography.
On Cognitive Assistant Robots for Reducing Variability in Industrial Human-Robot Activities

This work has been co-financed by the European Regional Development Fund of the European Union in the framework of the ERDF Operational Program of Catalonia 2014-2020, grant number 001-P-001643. Cecilio Angulo has been partly supported by the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 825619 (AI4EU).
Characterization of the interaction between recombinant estrogen receptor alpha and transcriptional coactivator SCR-1 NR-2 binding motif through fluorescence polarization study with Mithras LB 940

Hormonal regulation of gene activity is in part mediated by nuclear receptors (NR) acting as ligand-activated transcription factors (Mangelsdorf al., 1995). These proteins interact with the ligand, the DNA-response element and, in an agonist-dependent manner, with several proteins acting as transcriptional coactivators, such as CBP/p300, and the p160 family proteins (SRC-1, TIF-2, and SRC-3) (Robyr et al., 2000). These protein/protein interactions are mediated by means of two activation functions (AF), AF-1 located in the N-terminal region of the receptor, and AF-2 located in the hormone-binding domain.
THE EFFECT OF POLO DRILL SWIMMING ON FREESTYLE KINEMATICS: A PILOT STUDY

The purpose of this pilot study was to compare temporal performance variables and kinematic parameters during the entry and catch phase of freestyle and Polo drill swimming. Five well-trained freestyle swimmers performed 400 m of Polo drill and freestyle through a 8.91 m3 calibrated space recorded by eight synchronised cameras. Differences were assessed by a paired t-test and effect size (d) calculations for each variable. Significant differences occurred with respect to stroke length, stroke rate, stroke duration, entry and catch duration, hip velocity and vertical displacement and trunk inclination. The finger displacement and velocity, elbow angle and shoulder displacement were not significantly different through the entry and catch phase of the stroke. This work identified that while notable differences exist between freestyle and Polo drill swimming, there is an indication that some key parameters may be similar.
The Causal Interpretation of Two-Stage Least Squares with Multiple Instrumental Variables

Empirical researchers often combine multiple instrumental variables (IVs) for a single treatment using two-stage least squares (2SLS). When treatment effects are heterogeneous, a common justification for including multiple IVs is that the 2SLS estimand can be given a causal interpretation as a positively weighted average of local average treatment effects (LATEs). This justification requires the well-known monotonicity condition. However, we show that with more than one instrument, this condition can only be satisfied if choice behavior is effectively homogeneous. Based on this finding, we consider the use of multiple IVs under a weaker, partial monotonicity condition. We characterize empirically verifiable sufficient and necessary conditions for the 2SLS estimand to be a positively weighted average of LATEs under partial monotonicity. We apply these results to an empirical analysis of the returns to college with multiple instruments. We show that the standard monotonicity condition is at odds with the data. Nevertheless, our empirical checks reveal that the 2SLS estimate retains a causal interpretation as a positively weighted average of the effects of college attendance among complier groups. (JEL C26, I23, I26, J24, J31, R23)
Responsible data management

The need for responsible data management intensifies with the growing impact of data on society. One central locus of the societal impact of data are Automated Decision Systems (ADS), socio-legal-technical systems that are used broadly in industry, non-profits, and government. ADS process data about people, help make decisions that are consequential to people's lives, are designed with the stated goals of improving efficiency and promoting equitable access to opportunity, involve a combination of human and automated decision making, and are subject to auditing for legal compliance and to public disclosure. They may or may not use AI, and may or may not operate with a high degree of autonomy, but they rely heavily on data. In this article, we argue that the data management community is uniquely positioned to lead the responsible design, development, use, and oversight of ADS. We outline a technical research agenda that requires that we step outside our comfort zone of engineering for efficiency and accuracy, to also incorporate reasoning about values and beliefs. This seems high-risk, but one of the upsides is being able to explain to our children what we do and why it matters.
FORCE-SHARING BETWEEN TRICEPS SURAE MUSCLES DURING REHABILITATION EXERCISES FOR ACHILLES TENDINOPATHY

The purpose of this study was to determine individual muscle forces of the Triceps Surae during a range of rehabilitation exercises for Achilles tendinopathy. We used experimental data (N=4) and musculoskeletal modelling to estimate muscle force (dynamic optimization). We observed clear peak muscle force differences between exercises. In addition, the forcesharing strategies used by the participants (i.e., individual muscle contribution to the total force produced within the Triceps Surae) were different between exercises. These preliminary results could be helpful to objectively determine the progression in exercise loading throughout rehabilitation programs. Additionally, new information regarding the influence of the type of exercise on load distribution within the Triceps Surae may better orientate practitioners in the choice of exercise.
Stochastic Analysis and Mathematical Finance-A Fruitful Partnership

We analyze the pricing problem of an agent having additional (potentially insider) information on the market in a model-independent setup. Following Hobson’s approach we reformulate this problem as a constrained Skorokhod embedding problem, and show a natural supperreplication result. Furthermore, we establish a monotonicity principle for the constrained SEP, giving a geometric characterization of the support of the optimizers (in the spirit of Beiglboeck, Cox and Huesmann (2014)) which allows to link the additional information with geometric properties of the optimizers to the constrained embedding problem. Surprisingly, for certain types of information the absence of arbitrage can be easily checked by considering only unconstrained solutions. (The talk is based on a joint work with Alex Cox and Martin Huesmann.)
Impact assessment of a local seventeen-year initiative on cassava-based soil conservation measure on sloping land as a climate- smart agriculture practice in Van Yen District, Yen Bai Province, Vietnam

iv About the authors . v Acknowledgments . vi List of Tables . viii List of Figures . ix Acronyms and abbreviations . x I. Problem setting . 1 II. Research Objectives and Methodology . 3 Research objectives . 3 Methodology . 3 III. Research Results . 9 Description of surveyed households . 9 Economic impact assessment . 11 Environmental impact assessment . 18 Social impact assessment . 25 IV. Comments and recommendations . 31 Comments of results . 31 Recommendations . 36 References . 37 Appendices . 39
Inflation-Growth Nexus in Africa: Evidence from a Pooled CCE Multiple Regime Panel Smooth Transition Model

This paper analyses the empirical relationship between inflation and growth using a panel data estimation technique, Multiple Regime Panel Smooth Transition Regression (MR-PSTR), which takes into account the nonlinearities in the data. By using a panel data set for 10 African countries that permit us to control for unobserved heterogeneity at both country and time levels, we find that a statistically significant negative relationship exists between inflation and growth for the inflation rates above the critical threshold levels of 9% and 30% which are endogenously determined. Furthermore, we remedy the cross section dependence with the Common Correlated Effects (CCE) estimator. JEL Classification: C33, E31, O40
Structural Evolution of Banda Arc, Eastern Indonesia: As a Future Indonesian Main Oil and Gas Development*

In the last decade, exploration at Eastern Indonesia has seen rapid growth, as an impact of energy demand. Banda Arc is a result of the interaction of various plates as part of a complex geological history in Eastern Indonesia. The movement of the Australian plate relative to Banda Sea is to the NNE. Because Banda Arc is curved, the angle of plate convergence should be changed along the arc. It caused different implication for structural deformation along Banda Arc. It is high oblique compressional in the Timor area, low oblique transpressional to the east of Tanimbar, and changed from transpressional to transtensional in the area of Kai Islands. The petroleum system is well developed in the Banda Arc area. It is shown by some discoveries, including: Abadi Field, Bayu-Undan, Elang-Kakatua, Seram, Salawati Basin, and Bintuni Basin. Those discoveries come from Jurassic Sandstone and Miocene Kais Limestone reservoirs. However, there are some unsuccessful exploration wells in the Banda Arc area, which indicate there are some misinterpretations of the petroleum system and structure. These unsuccessful exploration wells proved that structural restoration need to be conducted to explain the unique structural evolution related to the petroleum system development in Banda Arc. This research discusses the result of an integrated study of 2D seismic interpretation and balancing cross-sections, as part of the structural geology evaluation in Banda Arc which concentrates in finding and determining the kinematics relationship among different faulting events. 2D seismic interpretations were concentrated in recognizing structural pattern and kinematics. Balancing cross-sections were concentrated in the stable part area of Banda Arc where mostly successful exploration wells existed. Based on palinspatic models made from 2D seismic, it indicated that deformation in the stable area of Banda Arc shows a group of contrasting strain features: early extensional faults forming the syn-rift deposit, reactivated by latter extensional structural style. Inversion structure evidence can be observed just only in the thrust fault zone, unstable part area of Banda Arc. The strain axis consistently shows maximum NE-SW direction of shortening in the thrust fault zone, but does not show NW-SE direction of extension. Therefore, it concluded that both structures (extensional and shortening) were formed during different deformation phases. This interpretation would guide exploration well planning for a better success ratio in Banda Arc, Eastern Indonesia.
Desktop Data Search for Big Data using Classifier and Indexer Technique

: Desktop data search is an important feature for any desktop and is essentially required too. For searching any big data the systems are required to have the search algorithms in order to access the hard disks and the connected storage spaces, sometimes it may get difficult to find the data manually by simply scanning the visible strings, that where the search algorithms comes handy. Search algorithms can be inspired from many technologies but they are needed to be very specific about the task and precise too.