Miracle-dz/UniFAR-FTUs huggingface dataset:
The effects of anticonvulsants on the memory function of epileptics

Some evidence suggests that anticonvulsants may impair memory function in epileptics. This study examined the effects of three major anticonvulsants, phenytoin, carbamazepine and sodium valproate, on the memory function of epileptic patients. Studies of the effects of anticonvulsants on memory function have been fraught with methodological problems. The results from studies of non-epileptics have limited applicability to the use of these drugs in clinical practice. Studies of epileptics, on the other hand, are often difficult to interpret because of methodological weaknesses largely inherent in examining clinical populations. In spite of these methodological difficulties, the effects of the drugs are of considerable interest. Anticonvulsants are used over very long periods, sometimes a whole life-time and on a significant proportion of the general population. There is a significant possibility that the side-effects of treatment may be worse than the benefits for some patients. This study examined epileptic patients in a clinical setting but attempted to improve on the research methodology that has generally been the case in the past. Experiment 1 examined previously untreated epileptics before and three months after monotherapy with phenytoin, carbamazepine or sodium valproate and compared these with untreated non-epileptic controls. Experiment 2 compared the memory performance of patients treated with phenytoin and then either remaining on phenytoin or switched to carbamazepine. Experiment 3 compared the memory performance of epileptics treated with carbamazepine and then either remaining on carbamazepine or switched to sodium valproate. Experiment 4 examined the relationships between dose and blood level of phenytoin, carbamazepine or sodium valproate and folate with memory function. The results of the study indicate that the effects of anticonvulsants on memory function are generally mild. Phenytoin was most frequently associated with impairment of memory. No evidence was found that carbamazepine produced any deterioration in memory performance. Experiment 4 indicated that folate levels, which are depleted by phenytoin, are more strongly correlated with impaired memory function than blood level of anticonvulsant. This observation supports previous findings that have implicated folate in the production of memory impairment. Nonetheless, the major conclusion of the study is that monotherapy with phenytoin, carbamazepine or sodium valproate, within or below the therapeutic range, does not seriously impair memory function. TABLE OF CONTENTS PAGE CHAPTER 1 GENERAL INTRODUCTION 1
Development of A Framework for Urban Heat Adaptation in 15-Minute City

Urban heat has challenged many cities with serious environmental, economic, social and health consequences. Urban heat also deteriorates the achievement of 15-Minute City (FMC) which is a basic community unit to apply planning and design practices to achieve safety, sustainability, resilience and inclusion required by the goal of Sustainable Cities and Communities (Goal 11) by the United Nations Sustainable Development Goals. Heat adaptation strategies are of importance to secure people from heat-induced immediate impacts. However, there are limited studies on how to integrate heat adaptation strategies into FMC for avoiding heat-induced impacts. Therefore, this paper aims to construct a framework that can support the integration of urban heat adaptation (UHA) into FMC planning and design. The framework is expected to combine FMC and UHA goals, identify urban heat impacts, recognise heat-induced impact influential factors, suggest heat adaptation strategies and optimise adaptation performance. Following this conception, an analysis of FMC and UHA goals, heat-induced impact and assessment indicators, regulatory factors, heat adaptation strategies, and sensitivity assessment models has been conducted. Finally, a comprehensive FMC-UHA framework for addressing urban heat challenges is generated. Overall, this framework provides a reference for creating cool 15-minute cities, as well as guidance on how to avoid heat impacts, health and safety inclusion, low-carbon travel, and outdoor productivity.
Fluid dynamic analysis of a cryogenic piston pump

Cryogenic piston pumps are commonly found in cryogenic systems to pressurize low-temperature liquefied fuels, such as liquified natural gas (LNG) or hydrogen, which are then gasified and stored in high-pressure vessels. The main challenges to be tackled in the design of these machines concern the low operating temperatures, high discharge pressures, and especially the need to avoid liquid evaporation, as this can lead to a reduction of volumetric efficiency or even to the shutdown of the pump. Two effects can cause the formation of vapor bubbles: cavitation, i.e., when the static pressure falls below the saturation value during the suction phase, and evaporation due to a temperature increase of the cryogenic liquid. In this study, a numerical analysis of a cryogenic single-piston pump is carried out. In the first part of the activity, the suction phase is studied through three-dimensional, steady-state CFD simulations. The performance of the pump in terms of pressure losses is evaluated and possible improvements to the suction geometry are identified. Then, two-phase steady-state Eulerian-Eulerian simulations are performed. The Rayleigh-Plesset model is used in order to evaluate the onset of cavitation. The minimum inlet pressure conditions that avoid cavitation are identified for two different geometries underlining the positive effect of the introduced modifications. Results show that the methodology applied in this work can lead to improvements in cryogenic pump design, reducing the static pressure losses and hence limiting the risk of cavitation.
Ataxia-telangiectasia

Objective Ataxia-telangiectasia (AT) is a rare, severe, and ineluctably progressive multisystemic neurodegenerative disease. Variant AT phenotypes have been described in patients with mild- and late-onset neurologic deterioration and atypical features (dystonia and myoclonus). We report on the clinical characteristics and transcriptome profile of patients with a typical AT presentation and genotype who experienced an unexpected favorable course. Methods A 24-year-old woman developed, by the age of 3 years, all the classic symptoms of AT associated with increased alpha-fetoprotein levels, a compound AT-mutated (ATM) genotype with an inframe deletion c.2250G>A (p.Glu709_Lys750del42) and a missense mutation c.8122G>A (p.Asp2708Gln), and no residual ATM protein expression. By the age of 12 years, ataxia slowly disappeared, and a very mild choreic disorder was the only neurologic feature in adulthood. Brain MRI was normal. The blood transcriptome profile was assessed and compared with that of healthy controls and patients with the classic AT phenotype. Results The atypical clinical course of the patient was associated with a transitional transcriptome profile: while 90% of transcripts were expressed as in patients with the classic AT presentation, 10% of transcripts were expressed as in healthy controls. Conclusions The unexpected mild clinical outcome and transcriptome profile of this patient with AT suggest the existence of individual resilience to the altered ATM synthesis. Because of their possible prognostic and therapeutic implications, the identification of modifier factors affecting the phenotype would deserve further studies.
The Issue of Mental and Motor Disturbances and Correction Thereof In Children with Infantile Cerebral Paralysis and Moderate Mental Retardation

Correction of the condition of children with infantile cerebral paralysis and moderately expressed mental retardation is a serious problem of modern recreation therapy. The goal of this article is to analyze the available information on the most important aspects of mental and motor disturbances in children with infantile cerebral paralysis and moderate mental retardation and to summarize the information on the most effective approaches for the compensation of such disturbances. The work contains information on primary mental and physical problems of mentally challenged children with infantile cerebral paralysis who require active compensation for the arrangement of conditions for the maximum possible health improvement and introduction of such children into the society. The articles deals with main approaches to the correction of psychomotor defects in case of infantile cerebral paralysis which proved to be effective in practice and which can be taken in case of moderate mental retardation. After the analysis of the available information on the problem, it becomes clear that there is still a need for additional development of options for the complex correction of existing disturbances in this category of children. Further development of new methods and the refinement of existing ones can result in the improvement of their health which should ensure the greater degree of their integration into society.
The Functioning of Patients with the Spinal Cord Stimulator Funkcjonowanie pacjentów z zaimplantowanym neurostymulatorem rdzeniowym

Introduction. Despite recent advancement in medical science, the effectiveness of therapies preventing or curing neuropathic pain is still not satisfactory enough. Aim. To assess the functional state of persons with the Spinal Cord Stimulator and their beliefs about pain management. Material and Methods. A total of 44 respondents with the Spinal Cord Stimulation (SCS) due to pain complaints in the lumbosacral region of the spine participated in the survey, in which the Roland–Morris Disability Questionnaire (RMDQ) and the Beliefs about Pain Control Questionnaire (BPCQ) were applied. Results. Physicians scored 18 points (i.e.: 75.0% of the maximum score) in the RMDQ in their attempts to reduce the experience of pain and the respondents’ degree of disability was assessed as 15.8 (±3.2 pts). Conclusions. Pain complaints significantly decreased the quality of life in patients with the neurostimulator. The greatest influence on pain control was ascribed by respondents to physicians’ attempts. (JNNN 2016;5(2):53–57)
Data Utility in Anonymised Clinical Study Reports (CSRs)

EMA Policy 0070 “Phase 1” has been effective since January 2016 and requires CSRs and other regulatory documents from central applications to be published in an anonymised format. While sponsors are favouring eliminating or minimising risk of re-identification of patients in data made public, EMA Policy 0070 requires sponsors to demonstrate that they have prioritised data utility in the anonymised CSRs published within the scope of the policy. The concept of data utility is not clearly defined in the associated anonymisation guidance and can be interpreted from the perspective of different data consumers with different needs and level of skills to interpret regulatory clinical documents. This paper will elaborate on the concept of data utility as outlined in EMA Policy 0070 and explore how different stakeholders (researchers, patients, health professionals, etc.) may use this wealth of information that has recently been made available in the context of central applications.
Gender differences in presentation and early survival in an antiretroviral therapy programme in Gugulethu : South Africa, 2002-2007

· By 2005, an estimated 500 000 people with HIV had initiated highly active antiretroviral therapy (HAART) in sub-Saharan Africa. However, disproportionately more women than men have accessed HAART in most developing countries including South Africa. While there has been considerable recent interest in the determinants of mortality among patients receiving HAART in developing countries, there is conflicting evidence about gender differences and survival in HAAR T programmes. This study explored whether there were gender differences in early mortality among 2 843 treatment-naive men and women entering care in a large South African HAART programme. The study was a secondary analysis of patient records covering three time periods: person-time from programme entry to the initiation ofHAART; person-time from HAART initiation to one year on treatment; and the total person-time from programme entry to one year on HAART. Cox' s proportional hazards regression ·was used to investigate crude and adjusted associations between basehne characteristics and mortality as we11 as loss-to-follow-up (LTFU). Using the Sobel test, the study explored whether the degree of disease ( according to CD4 count and WHO stage) played a mediating role in any association between gender and mortality. In all three time periods, the analysis found a strong crude associ~tiol). between male gender and mortality. Prior to HAART-initiation, there was a 31 % increase in the risk of mortality (crude Hazard Ratio (HR) 1.31, 95% CI, 0.931. 86; p=0.131). In the period on HAART, this association strengthened (crude HR 1.57, 95% CI, 1.14-2.16; p=0.005). Overall, male gender increased the risk of mortality in the total cohort by 49% (crude HR, 1.49, 95% CI, 1.17-1.88; p=OOl). Adjustment for baseline characteristics, including CD4 count and WHO stage, attenuated these crude associations. After adjustment, there was no increase in risk associated with male gender in the period pre-HAART (HR 1.01, 95% CI, 0.67-1.51). On HAART, there was a 19% increase in risk (HR 1.19, 95% CI, 0.88-1.67). In the total cohort, this was slightly attenuated (HR 1.15, 95% CI,
UK Renal Registry 14th Annual Report: Introduction

The UK Renal Registry (UKRR) provides independent audit and analysis of renal replacement therapy (RRT) in the UK. The UKRR is part of the UK Renal Association and is funded directly by participating renal centres through an annual capitation fee per patient per annum. The UKRR remains relatively unique amongst renal registries in publishing both centre-specific analyses of indicators of quality of care, such as haemoglobin and also age-adjusted survival statistics for each renal centre. Data are provided from all renal centres in the UK. For adult patients the UKRR receives quarterly electronic data extracts from information systems used for clinical and administrative purposes within each renal centre in England, Wales and Northern Ireland. Data from Scotland is received via the Scottish Renal Registry. Details of how the UKRR extracts, analyses and reports on data for patients on RRT have been described previously [1]. The UKRR has also taken on the role of collecting paediatric data. This task is somewhat different from the collection of data from adult centres as many paediatric centres do not have clinical information systems which are used for day-to-day patient care. This is a major project as it is necessary to prepare and amalgamate the existing paediatric data for inclusion in the UKRR database and to develop methods of obtaining data from the paediatric centres: this project is well under way. This report contains analyses of data related to patient care in 2010. The inclusion of laboratory data permits analyses not only of the incidence, prevalence and outcomes of RRT in the UK, but also the achievement of clinical performance measures as defined by the Renal Association’s Clinical Practice Guidelines. These guidelines present audit targets for forthcoming years for centres and challenges for the software extraction routines (see www.renal.org).
8 Regulation and Compartmentalization of Lipid Synthesis in Yeast

I. INTRODUCTION The membrane lipids of Saccharomyces cerevisiae are similar to those of other eukaryotic organisms. Yeast synthesizes sterols, and its membranes contain a typically eukaryotic mixture of phospholipids, including phosphatidylcholine and inositol-containing phospholipids. Unlike other eukaryotes, however, S. cerevisiae does not synthesize ether lipids, and its fatty acids are predominantly 16 and 18 carbons in length. Considerable progress has recently been made in determining how the biosynthesis of phospholipids is compartmentalized within the yeast cell and how phospholipids are transported between membrane compartments. In addition, during the decade since the first edition of The Molecular Biology of the Yeast Saccharomyces was published, remarkable progress has been made in characterizing the enzymes of phospholipid biosynthesis and identifying and isolating their structural genes. A combination of molecular and genetic studies has revealed a complex pattern of regulation governing the expression of a number of genes encoding phospholipid biosynthetic enzymes. Because of its powerful genetics and molecular biology, yeast will be an increasingly important organism for the analysis of these processes, which are crucial to all eukaryotic organisms. II. PATHWAYS OF LIPID SYNTHESIS AND UPTAKE OF LIPIDS INTO YEAST CELLS The lipid matrices of all subcellular membranes of yeast are composed of essentially the same set of polar lipids and sterols. However, the relative proportions of individual lipid classes vary considerably between different organelle membranes. Furthermore, the lipid compositions of particular membranes can be varied significantly by altering growth conditions such as temperature, nutrient supply, oxygen concentration, and growth rate. In addition,.
Pix2Pix GAN Image Synthesis To Detect Electric Vehicle License Plate

The area of image processing is more intensive in development and research activities for decades. The role of image processing is huge in modeling, analytics, communication, computation, information security, information forensics and smart city application. Images are ubiquitous in day to day life and images or videos play dominant role in monitoring applications. But when it comes to development of specific application, collection of data is a very challenging task. Nowadays deep learning plays a significant role for generation of data. Robust technologies like Generative Adversarial Network (GAN) and Cycle GAN play a crucial role for generating realistic images with super resolution. GAN and its associated methods used for image synthesis improve the accuracy of deep learning models. In this paper, we analyze challenges of license plate recognition in realistic situation and experiments demonstrate that GAN can generate realistic images to improve the accuracy of license plate recognition.
Lung Function Test among Abrasive Blasting Workers in Lumut, Perak

Abrasive blasting process is a common process in marine industry. This process was use as main cleaning process method and normally will release fine dust that hazardous to human health. Main effect from fine dust to human health are respiratory failure such as chronic obstructive pulmonary disease (COPD). Lung function test can be used to detect any respiratory problems in human. The objective of the research to evaluate the effect of dust exposure from abrasive blasting to the workers. This study are conduct among workers work in dusty environment in Lumut, Perak, Malaysia. FEV1/FVC value from lung function test were evaluated to determine the severity of COPD among workers. While FEV1 prediction show restrictive pattern and use to determine any respiratory or lung problems among the workers. From the result, it does not show any COPD problem among workers. However, FEV1 show that some workers need to go for detail medical surveillance because of the result is less than 0.8. Employer and workers need to understand and know their work related risk to minimize the risk arising from their job or work conducted.
Response-Adapted Therapy with Infusional EPOCH Chemotherapy Plus Rituximab in HIV-Associated, B-Cell Non-Hodgkin's Lymphoma

Introduction: Six cycles of rituximab plus infusional EPOCH is considered a preferred regimen for first-line treatment of HIV-associated diffuse large B-cell lymphoma (DLBCL), HHV8-positive DLBCL, and primary effusion lymphoma, and is among the preferred regimens for HIV-associated Burkitt's lymphoma in the 2019 NCCN guidelines. A phase III trial demonstrated non-inferiority of 4 cycles of R-CHOP (followed by 2 additional doses of rituximab) compared with 6 cycles of R-CHOP in immunocompetent patients with low-risk DLBCL (stage I-II, age 18-60 years, and an age-adjusted International Prognostic Index score of 0), indicating that de-escalation of treatment duration may be safely achieved without compromising curability in an appropriately selected patient population. Here we report the outcomes for patients with HIV-associated DLBCL and high-grade non-Hodgkin lymphoma (NHL) treated with 4-6 cycles of EPOCH plus rituximab based a response-adapted treatment strategy under a completed prospective clinical trial (AMC-034). Methods: One hundred-six patients with HIV-associated DLBCL or high-grade CD20-positive NHL enrolled at multiple centers across the U.S. were randomized to receive rituximab (375 mg/m2) given either concurrently prior to each infusional EPOCH cycle, or sequentially (weekly for 6 weeks) following completion of dose-adjusted EPOCH regimen tailored for HIV+ patients. EPOCH consisted of a 96-hour IV infusion of etoposide, doxorubicin, and vincristine plus oral prednisone followed by IV bolus cyclophosphamide every 21 days for 4 to 6 cycles. Patients received 2 additional cycles of therapy after documentation of a complete response (CR) by computerized tomography after cycles 2 and 4. Results: Sixty-four of 106 patients (60%, 95% CI 50%, 70%) had a CR in both treatment arms; characteristics of entire population and CR proportions stratified by number of EPOCH treatment cycles were similar (Table 1). The 2-year event-free survival (EFS) rates were similar in the 24 patients with CR who received 4 or fewer EPOCH cycles (78%, 95% confidence intervals [55%, 90%]) due to achieving a CR after 2 cycles, compared with those who received 5-6 cycles of EPOCH (85%, 95% CI 70%, 93%) due to failure to achieve a CR after 2 cycles (Table 2 and Figure 1). Time to disease progression and overall survival wer also similar for those treated with 4 or fewer cycles compared with 5-6 cycles (91% vs. 87%, and 78% vs. 90%, respectively) (Table 2 and Figure 1). Conclusion: A response-adapted strategy may permit a shorter treatment duration without compromising therapeutic efficacy in an appropriately selected population of patients with HIV-associated NHL, which merits further evaluation in additional prospective trials. Noy: Janssen: Consultancy; Medscape: Honoraria; Prime Oncology: Honoraria; NIH: Research Funding; Pharamcyclics: Research Funding; Raphael Pharma: Research Funding.
Effect of Heart Rate Variability Biofeedback on Sleep

iii List of Tables . vi List of Figures . vii Chapter 1: Introduction and Specific Aims . 1 Chapter 2: Background . 6 Chapter 3: Methods . 15 Chapter 4: Results . 27 Chapter 5: Discussion . 46 References . 51 Appendix A: Supplemental Materials . 56