Miracle-dz/UniFAR-FTUs huggingface dataset:
Revisiting Elementary Denotational Semantics

Operational semantics have been enormously successful, in large part due to its flexibility and simplicity, but they are not compositional. Denotational semantics, on the other hand, are compositional but the lattice-theoretic models are complex and difficult to scale to large languages. However, there are elementary models of the $\lambda$-calculus that are much less complex: by Coppo, Dezani-Ciancaglini, and Salle (1979), Engeler (1981), and Plotkin (1993). This paper takes first steps toward answering the question: can elementary models be good for the day-to-day work of language specification, mechanization, and compiler correctness? The elementary models in the literature are simple, but they are not as intuitive as they could be. To remedy this, we create a new model that represents functions literally as finite graphs. Regarding mechanization, we give the first machine-checked proof of soundness and completeness of an elementary model with respect to an operational semantics. Regarding compiler correctness, we define a polyvariant inliner for the call-by-value $\lambda$-calculus and prove that its output is contextually equivalent to its input. Toward scaling elementary models to larger languages, we formulate our semantics in a monadic style, give a semantics for System F with general recursion, and mechanize the proof of type soundness.
WHAT ADDITIONAL INFORMATION CAN PROVIDE DOPPLER MYOCARDIAL IMAGING FOR DAILY CLINICAL PRACTICE ?

The present review is designed to demonstrate some most practical and widely recognized areas of clinical Doppler myocardial imaging (DMI) application. The history and principles of the method are briefly described. In order to understand the potential of myocardial velocity imaging, the relationship between myocardial architecture and function is covered. The attention is focused on possibilities of DMI to diagnose and monitor myocardial ischemia and evaluate global and regional diastolic function. Other applications of DMI in daily practice and perspectives of the method are reviewed as well.
Un proceso iterativo para la refactorización de aspectos

El desarrollo de software orientado a aspectos permite encapsular concerns que cortan transversalmente las componentes funcionales de una aplicacion, mejorando la modularizacion y como consecuencia el mantenimiento de la aplicacion. Por esta razon, para aprovechar los beneficios de la orientacion a aspectos surge la necesidad de migrar los sistemas orientados a objetos existentes a la orientacion a aspectos mejorando el mantenimiento y evolucion de los mismos. En este trabajo se presenta un proceso iterativo que asiste durante la tarea de migracion de una aplicacion orientada a objetos a una orientada a aspectos. Una vez que los aspectos han sido identificados por medio de alguna tecnica de aspect mining se utilizan patrones de estructura que permiten identificar el refactoring a aplicar para generar el codigo orientado a aspectos resultante, aspect refactoring.
Fusion of a signal sequence to the interleukin-1 beta gene directs the protein from cytoplasmic accumulation to extracellular release.

Interleukin (IL)-1 differs from most other cytokines by the lack of a signal sequence, which results in the retention of the immature proform intracellularly (i.c.). Several cell types have the capacity to produce IL-1, but release has been shown to be restricted predominantly to monocytes/macrophages and associated with apoptosis of the producer cell. These features have limited the studies on IL-1 in early T cell-APC interactions. To develop a model for studying the biological effects of IL-1 beta release during long-lasting immune responses, we have established cells transfected with IL-1 beta cDNA constructs. To construct a hybrid gene for IL-1 beta release, the signal sequence from the related IL-1 receptor antagonist was fused to the gene encoding the 17-kDa mature form of IL-1 beta. A murine fibroblast cell line was transduced with retroviral technique and analyzed for the expression of human IL-1 beta, with or without a signal sequence (ssIL-1 beta and IL-1 beta, respectively). The fibroblasts transduced with either IL-1 beta or ssIL-1 beta expressed similar levels of human IL-1 beta mRNA. High levels of IL-1 bioactivity were recorded in freeze-thaw extracts from cells expressing the IL-1 beta protein i.c. , and in supernatants of ssIL-1 beta-transduced cells, which indicates that the initial formation of a proform of IL-1 beta is not required for correct folding of the protein. Treatment of ssIL-1 beta-transduced cells with Brefeldin A (BFA), an inhibitor of protein transport in the endoplasmatic reticulum, induced accumulation of the protein i.c. BFA treatment did not affect IL-1 beta-transduced cells, while lipopolysaccharide-activated human monocytes increased the secretion of IL-1 beta. Cytoplasmic staining of single cells demonstrated that expression of the ssIL-1 beta gene directed the protein to a perinuclear Golgi-like compartment, whereas cells transduced with IL-1 beta cDNA showed a diffuse cytoplasmic distribution pattern. Secretion of IL-1 beta from human monocytes was under certain conditions accompanied by cell death. In contrast, in the fibroblast cell line transduced to secrete IL-1 beta, no accompanying cell death could be detected. Gene targeting of IL-1 to the secretory or cytoplasmic pathway may be useful for elucidating the role of IL-1 in T cell-APC interactions, avoiding cell death of the producer cells.
Practical Design Guidelines for the Development of High-Precision Roll-to-Roll Slot-Die Coating Equipment and the Process

This paper proposes practical design guidelines for roll-to-roll (R2R) slot-die coating equipment with a precision mechanism enabling high-accuracy coating performance. The equipment is developed for specially fabricating organic photovoltaic devices. An R2R transportation module (capable of unwinding, in-feeding, out-feeding, and rewinding), a slot-die coating module, a far-infrared drying module, and a cleanliness control module are incorporated into the equipment. When used to apply an organic solution, the developed equipment can provide an operating tension of 2.3%-11.3%, a coating velocity of 2-7 m/min, a coating thickness of 28-95 nm, a uniformity of 8%-23%, and a roughness of 2.86-7.71 nm. A review of this equipment on the basis of theoretical and experimental approaches is included in the detailed equipment specifications and design guidelines for R2R slot-die coating machines.
Deep Data Anaylizing Application Based on Scale Space Theory in Big Data Environment

This paper introduces the basic scientific idea of the multi-scale to the field of big data analyzes, proposes a multi-scale framework of data analyzes in big data environment, present the multi-scale algorithm framework of knowledge conversion theory and apply the algorithm framework to the multi dimension association rules analysis. The proposed multi-scale association rule analysis algorithm uses the benchmark data set of analyzing results and the influence weight of benchmark data sets for target scale data sets to derived the association rules behind object scale data set, realize knowledge across scales derived and provide the possibility for multi-scale decision. Keywords-Scale Space; Big Data; Frequent Item-set;
NTUCLE: Developing a Corpus of Learner English to Provide Writing Support for Engineering Students

This paper describes the creation of a new annotated learner corpus. The aim is to use this corpus to develop an automated system for corrective feedback on students’ writing. With this system, students will be able to receive timely feedback on language errors before they submit their assignments for grading. A corpus of assignments submitted by first year engineering students was compiled, and a new error tag set for the NTU Corpus of Learner English (NTUCLE) was developed based on that of the NUS Corpus of Learner English (NUCLE), as well as marking rubrics used at NTU. After a description of the corpus, error tag set and annotation process, the paper presents the results of the annotation exercise as well as follow up actions. The final error tag set, which is significantly larger than that for the NUCLE error categories, is then presented before a brief conclusion summarising our experience and future plans.
The polarization of fibroblasts in early primary cultures is independent of microtubule integrity.

Fibroblasts in culture apparently require an intact system of microtubules in order to adopt and maintain a polarized morphology. In contrast, the polarization of a number of epithelial cell types has been shown to be microtubule-independent. Reconciliation of these apparently contradictory data is difficult, however, because the epithelial cells were studied in short-term primary cultures while the fibroblasts were studied in secondary or longer-term cultures. To clarify the situation we have examined the effects of the microtubule-disrupting drugs, colcemid and nocodazole, on the polarization of a single cell type, the chick heart fibroblast (HF), maintained in both primary (1 degree) and secondary (2 degree) cultures. Immunofluorescence observations of both types of culture showed that in control medium the cells contained abundant microtubules, which were absent if the cells were cultured in medium containing either colcemid or nocodazole. The effects of microtubule-disrupting drugs on the polarization of the cells were quantified using two measures of cell shape, elongation and dispersion, both of which increase with increasing polarization. The results show that microtubule-disrupting drugs do not have a significant effect on the polarization of HF spreading in 1 degree culture but significantly reduce the polarization of HF spreading in 2 degree cultures. The effects of microtubule disruption on HF that had been maintained in 1 degree culture for 6 h, 24 h or 48 h were also quantified. (ABSTRACT TRUNCATED AT 250 WORDS)
Children's values and friendships: a study of physical disability.

An element in the concept of a value is that values influence behavior. The relation between value and behavior is examined, using children's values toward physical handicaps and their choice of best friend in a summer camp where children with and without physical handicaps live together. It is hypothesized that children whose individual values toward handicaps are similar to the group value will choose as best friend someone who is not handicapped, whereas children with individual values that are atypical of the group value will choose someone who is handicapped. For children without handicaps, the hypothesis was confirmed early in the camping experience, but not after they had been at camp for two weeks. For children with visible physical handicaps, the results were contrary to the hypothesis late in the camp experience, and no association was found early.
Parameters selection in the cross-correlation based velocimetry using electrostatic sensors

Cross-correlation methods in combination with electrostatic sensing technology offer a promising solution to the on-line continuous measurement of velocity of particulate solids in pneumatic pipelines. The sampling frequency and integral time are two fundamental parameters in cross-correlation calculation. This paper describes the principles and steps of the selection of these two parameters. The measurement error of the transit time and the real application requirement are taken into account. Additionally, an experimental platform was built and the principles in selecting the parameters in the electrostatic correlation based velocity measurement were proven.
A Stochastic Forecast of California Earthquakes Based on Fault Slip and Smoothed Seismicity

We present a testable stochastic earthquake source model for intermedi- ate- to long-term forecasts. The model is based on fundamental observations: the frequency-magnitude distribution, slip rates on major faults, long-term strain rates, and source parameter values of instrumentally recorded and historic earthquakes. The basic building blocks of the model are two pairs of probability density maps. The first pair consists of smoothed seismicity and weighted focal mechanisms based on observed earthquakes. The second pair corresponds to mapped faults and their slip rates and consists of smoothed moment-rate and weighted focal mechanisms based on fault geometry. We construct from the model a "stochastic event set," that is to say, a large set of simulated earthquakes that are relevant for seismic hazard calculations and earthquake forecast development. Their complete descriptions are determined in the following order: magnitude, epicenter, moment tensor, length, displacement, and down-dip width. Our approach assures by construction that the simulated magnitudes are consistent with the observed frequency-magnitude distribution. We employ a magnitude-dependent weighting procedure that tends to place the largest simulated earthquakes near major faults with consistent focal mechanisms. Nevertheless, our stochastic model allows for surprises such as large off-fault earthquakes, events that comply with the observation that several recent destructive earthquakes occurred on previously unknown fault structures. We apply our model to California to illustrate its features.
High-frequency hearing impairment assessed with cochlear microphonics

Abstract Conclusion: Cochlear microphonic (CM) measurements may potentially become a supplementary approach to otoacoustic emission (OAE) measurements for assessing low-frequency cochlear functions in the clinic. Objective: The objective of this study was to investigate the measurement of CMs in subjects with high-frequency hearing loss. Currently, CMs can be measured using electrocochleography (ECochG or ECoG) techniques. Both CMs and OAEs are cochlear responses, while auditory brainstem responses (ABRs) are not. However, there are inherent limitations associated with OAE measurements such as acoustic noise, which can conceal low-frequency OAEs measured in the clinic. However, CM measurements may not have these limitations. Methods: CMs were measured in human subjects using an ear canal electrode. The CMs were compared between the high-frequency hearing loss group and the normal-hearing control group. Distortion product OAEs (DPOAEs) and audiogram were also measured. Results: The DPOAE and audiogram measurements indicate that the subjects were correctly selected for the two groups. Low-frequency CM waveforms (CMWs) can be measured using ear canal electrodes in high-frequency hearing loss subjects. The difference in amplitudes of CMWs between the high-frequency hearing loss group and the normal-hearing group is insignificant at low frequencies but significant at high frequencies.
East–west differentiation in the Marcusenius macrolepidotus species complex in Southern Africa: the description of a new species for the lower Cunene River, Namibia (Teleostei: Mormyridae)

This paper critically compares the Southern African bulldog fish species Marcusenius macrolepidotus (Peters, 1852), inhabiting the eastern Lower Zambezi River, and Marcusenius altisambesi Kramer et al., 2007, inhabiting the central Upper Zambezi River, with bulldog fish samples from the western lower Cunene River, a 2600-km range from the Indian Ocean to the Atlantic. The three species or forms are well differentiated in morphology and molecular genetics, and differentiation is also present in electric organ discharges. Marcusenius altisambesi and the Cunene sample, which we recognize as Marcusenius multisquamatus sp. nov., are closely related and form a sister taxon to M. macrolepidotus. This result is based on the analysis of mitochondrial cytochrome b sequences and genomic Inter-simple-sequence-repeat fingerprinting. Morphological adaptations to life in a torrential escarpment river seem to be present in M. multisquamatus sp. nov. when compared with M. altisambesi, which lives in a reservoir river that periodically floods the savannah. http://www.zoobank.org/urn:lsid:zoobank.org:pub:8FE68494-9ED9-428E-B181-E814D25493F2
Larval Morphometrics and Influence of Adults on Settlement in the Gregarious Ophiuroid Ophiothrix fragilis (Echinodermata)

The development of Ophiothrix fragilis was documented using light microscopy, and the allometry of larval growth was quantified. Larval development to the suspended juvenile stage took 21 days under conditions that were probably optimal compared to those in the plankton. Larval shape changed through development as the larval body and arms grew. Growth of the posterolateral larval arms was continuous throughout development, even during metamorphosis when the larva became endotrophic. During this period, these larval arms function as locomotory organs, and their continuous growth is probably essential to support the juvenile as it increases in density through development of its calcareous plates. In induction assays using adult conspecifics, initiation of metamorphosis was spontaneous. Release of the posterolateral arms was induced by the presence of adults. This response is likely to enhance a juvenile’s chance of recruiting to a suitable habitat in the Ophiothrix fragilis beds of the North Sea.
Effects of catecholamines on hepatic and skeletal muscle mitochondrial respiration after prolonged exposure to faecal peritonitis in pigs

Use of norepinephrine to increase blood pressure in septic animals has been associated with increased efficiency of hepatic mitochondrial respiration. The aim of this study was to evaluate whether the same effect could be reproduced in isolated hepatic mitochondria after prolonged in vivo exposure to faecal peritonitis. Eighteen pigs were randomized to 27 h of faecal peritonitis and to a control condition (n = 9 each group). At the end, hepatic mitochondria were isolated and incubated for one hour with either norepinephrine or placebo, with and without pretreatment with the specific receptor antagonists prazosin and yohimbine. Mitochondrial state 3 and state 4 respiration were measured for respiratory chain complexes I and II, and state 3 for complex IV using high-resolution respirometry, and respiratory control ratios were calculated. Additionally, skeletal muscle mitochondrial respiration was evaluated after incubation with norepinephrine and dobutamine with and without the respective antagonists (atenolol, propranolol and phentolamine for dobutamine). Faecal peritonitis was characterized by decreasing blood pressure and stroke volume, and maintained systemic oxygen consumption. Neither faecal peritonitis nor any of the drugs or drug combinations had measurable effects on hepatic or skeletal muscle mitochondrial respiration. Norepinephrine did not improve the efficiency of complex I- and complex II-dependent isolated hepatic mitochondrial respiration [respiratory control ratio (RCR) complex I: 5.6 ± 5.3 (placebo) vs. 5.4 ± 4.6 (norepinephrine) in controls and 2.7 ± 2.1 (placebo) vs. 2.9 ± 1.5 (norepinephrine) in septic animals; RCR complex II: 3.5 ± 2.0 (placebo) vs. 3.5 ± 1.8 (norepinephrine) in controls; 2.3 ± 1.6 (placebo) vs. 2.2 ± 1.1 (norepinephrine) in septic animals]. Prolonged faecal peritonitis did not affect either hepatic or skeletal muscle mitochondrial respiration. Subsequent incubation of isolated mitochondria with norepinephrine and dobutamine did not significantly influence their respiration.
Surgical Satisfaction, Quality of Life, and Their Association After Gender-Affirming Surgery: A Follow-up Study

ABSTRACT We assessed the outcomes of gender-affirming surgery (GAS, or sex-reassignment surgery) 4 to 6 years after first clinical contact, and the associations between postoperative (dis)satisfaction and quality of life (QoL). Our multicenter, cross-sectional follow-up study involved persons diagnosed with gender dysphoria (DSM-IV-TR) who applied for medical interventions from 2007 until 2009. Of 546 eligible persons, 201 (37%) responded, of whom 136 had undergone GAS (genital, chest, facial, vocal cord and/or thyroid cartilage surgery). Main outcome measures were procedure performed, self-reported complications, and satisfaction with surgical outcomes (standardized questionnaires), QoL (Satisfaction With Life Scale, Subjective Happiness Scale, Cantril Ladder), gender dysphoria (Utrecht Gender Dysphoria Scale), and psychological symptoms (Symptom Checklist-90). Postoperative satisfaction was 94% to 100%, depending on the type of surgery performed. Eight (6%) of the participants reported dissatisfaction and/or regret, which was associated with preoperative psychological symptoms or self-reported surgical complications (OR = 6.07). Satisfied respondents’ QoL scores were similar to reference values; dissatisfied or regretful respondents’ scores were lower. Therefore, dissatisfaction after GAS may be viewed as indicator of unfavorable psychological and QoL outcomes.
Spin gain transistor in ferromagnetic semiconductors-the semiconductor Bloch-equations approach

A scheme and principle of operation of a "spin gain transistor" are proposed. A large unmagnetized current creates the carrier density sufficient for the ferromagnetic transition; a small magnetized current initiates spontaneous magnetization. Large magnetized current is then extracted. Thus, spin gain of >1000 is predicted. Collective dynamics of spins under Coulomb exchange interaction is described via semiconductor Bloch equations.
Molecular and morphological characterisation of Rhabdias picardiae Junker, Lhermitte-Vallarino et Bain, 2010 (Nematoda: Rhabdiasidae) from Delaland’s River Frog, Amietia delalandii (Duméril et Bibron, 1841) (Amphibia: Pyxicephalidae) in South Africa

Rhabdias picardiae previously known from the Guttural Toad, Sclerophrys gutturalis (Bufonidae) is described from a new host, Delaland’s River Frog, Amietia delalandii (Pyxicephalidae). The species identification is confirmed by analysis of the COI gene sequence and morphological comparison with the original description. Morphological details of apical structures in adult parasitic R. picardiae, namely, the shape and position of lips, the number and position of external labial papillae, and the buccal capsule morphology are described using light and scanning electron microscopy. The buccal capsule width and length, the distance from anterior end to nerve ring and excretory pore, and ratios of distance to vulva to body length and body length to width were identified as less variable metrical characters in the studied sample of 30 specimens. Adult specimens demonstrated differences in the position of lips in relation to the oral opening and position of the buccal capsule in relation to the oesophagus depending on the size (age) of worms. The infective larvae of R. picardiae are described for the first time and characterised by two lateral alae consisting of two ridges, triangular pseudolabia with rounded tops, and presence of ornamentation on the rounded tail tip.