Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of Rest Interval Duration on Muscular Power Production in the Lower-Body Power Profile

Abstract Nibali, ML, Chapman, DW, Robergs, RA, and Drinkwater, EJ. Influence of rest interval duration on muscular power production in the lower-body power profile. J Strength Cond Res 27(10): 2723–2729, 2013—There is a paucity of evidence-based support for the allocation of rest interval duration between incremental loads in the assessment of the load-power profile. We examined the effect of rest interval duration on muscular power production in the load-power profile and sought to determine if greater rest is required with increasing load (i.e., variable rest interval). Ten physically trained men completed 4 experimental conditions in a crossover balanced design. Participants performed jump squats across incremental loads (0–60 kg) on 4 occasions, with an allocated recovery interval of 1, 2, 3, or 4 minutes. The mean log-transformed power output at each load was used for comparison between conditions (rest intervals). Unloaded jump squats (0 kg) maximized power output at each condition. The maximal mechanical power output was 66.6 ± 6.5 W·kg−1 (1 minute), 66.2 ± 5.2 W·kg−1 (2 minutes), 67.1 ± 5.9 W·kg−1 (3 minutes), and 66.2 ± 6.5 W·kg−1 (4 minutes). Trivial or unclear differences in power output were observed between rest intervals at each incremental load. As expected, power declined per 10 kg increment in load, the magnitude of decrease was 13.9–14.5% (confidence limits [CL]: ±1.3–2.0%) and 13.4–14.6% (CL: ±2.4–3.9%) for relative peak and mean power, respectively, yet differences in power output between conditions were likely insubstantial. The prescription of rest intervals between loads that are longer than 1 minute have a likely negligible effect on muscular power production in the jump squat incremental load-power profile. Practitioners should select either a 1- to 4-minute rest interval to best accommodate the logistical constraints of their monitoring sessions.
Acinetobacter: A potential reservoir and dispenser for β-lactamases

Innate resistance and remarkable ability to acquire additional resistance determinants underline the clinical importance of Acinetobacter. Over 210 β-lactamases belonging to 16 families have been identified in the genus, mostly in clinical isolates of A. baumannii. In this review, we update the current taxonomy of the genus Acinetobacter and summarize the β-lactamases detected in Acinetobacter spp. with an emphasis on Acinetobacter-derived cephalosporinases (ADCs) and carbapenem-hydrolysing class D β-lactamases (CHDLs). We also discuss the roles of integrons and insertion sequence (IS) elements in the expression and dissemination of such resistance determinants.
American association of clinical endocrinologists and american college of endocrinology position statement on the 2014 advanced framework for a new diagnosis of obesity as a chronic disease.

I am writing on behalf of the American Association of Clinical Endocrinologists (AACE). With 5,500 domestic members and more than 6500 members worldwide, we represent the largest group of practicing endocrinologists in the world. AACE would like to express our strong concern that the current requirements of the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program are creating a barrier to patient care by: (1) monopolizing physician time, (2) driving many previously “grandfathered” endocrinologists out of practice and (3) creating unwarranted confusion in the patient and payor communities regarding quality of care issues.
Practical Blood Flow Restriction Training Increases Acute Determinants of Hypertrophy Without Increasing Indices of Muscle Damage

Abstract Wilson, JM, Lowery, RP, Joy, JM, Loenneke, JP, and Naimo, MA. Practical blood flow restriction training increases acute determinants of hypertrophy without increasing indices of muscle damage. J Strength Cond Res 27(11): 3068–3075, 2013—Vascular blood flow restriction (BFR) training stimulates muscle hypertrophy by increasing muscle activation and muscle swelling. Previous studies used expensive pneumatic cuffs, which may not be practical for regular use. The aim was to investigate the acute effects of low-intensity practical BFR (LI-pBFR) on muscle activation, muscle swelling, and damage. Twelve trained male participants completed a 30-, 15-, 15-, 15-repetition scheme at 30% of their leg press 1-repetition maximum under control and LI-BFR conditions. Under the LI-BFR trial, knee wraps were applied to the thighs at a pressure that resulted in venous, not arterial, occlusion. In the control trial, wraps were applied with zero pressure. Ultrasound-determined muscle thickness was recorded at baseline; 0 minutes post with wraps; 0, 5, and 10 minutes post without wraps. Muscle activation was recorded during warm-ups and on the final set of 15 repetitions. Indices of muscle damage (soreness, power, and muscle swelling) were also recorded. There was a condition by time effect for muscle thickness (p < 0.0001, effect size [ES] = 0.5), in which muscle thickness increased in the LI-pBFR condition 0 minutes post with wraps and through 5 minutes post without wraps. No changes occurred in the control. There was a condition by time effect for muscle activation (p < 0.05, ES = 0.2). The LI-pBFR had greater activation than the control did. There were no condition by time effects on indices of muscle damage. Our data indicate that practical BFR significantly increases muscle activation and muscle thickness without increasing indices of damage.
From endocytosis to membrane fusion: emerging roles of dynamin in virus entry

Dynamin, a large guanosine triphosphatase (GTPase), has been implicated in virus entry, but its mechanisms of action are controversial. The entry procedure of most enveloped viruses involves endocytosis and membrane fusion. Dynamin has been suggested to act both as a regulatory GTPase by controlling the early stages of clathrin-mediated endocytosis (CME), which is an important endocytic pathway utilized by many viruses, and as a mechanchemical enzyme that induces membrane fission and pinches endocytic vesicles off from the cellular plasma membrane in later stages in several endocytic pathways, including CME. In addition to its involvement in virus endocytosis, dynamin has also been proposed to participate in membrane fusion between the virus and endosomes following endocytosis. Crystal structures and cryo-electron micrography (cryo-EM) have elucidated the structure of dynamin, which led to development of a mechanochemical model of how dynamin-mediated membrane fission occurs. Based on this, we propose a hypothetical model that explains how dynamin facilitates virus membrane fusion and discuss its roles in virus entry.
Neuromuscular Characteristics of Drop and Hurdle Jumps With Different Types of Landings

Abstract Cappa, DF and Behm, DG. Neuromuscular characteristics of drop and hurdle jumps with different types of landings. J Strength Cond Res 27(11): 3011–3020, 2013—The objective of this study was to compare drop (DJ) and hurdle jumps using a preferred, flat foot (FLAT) and forefoot (FORE) landing technique. Countermovement jump height was used to establish the hurdle and the DJ heights. The subjects performed forward hurdles and vertical DJs on a force plate. Measures included vertical ground reaction force (VGRF), contact time, leg stiffness, and rate of force development (RFD). Electromyographic (EMG) activity was measured in the rectus femoris, biceps femoris, tibialis anterior, and gastrocnemius during 3 phases: preactivity, eccentric phase, and concentric phase. All the kinetic variables favored hurdles over DJs. Specifically, hurdle-preferred technique and FORE exhibited the shortest contact time and DJ FLAT the longest. The VGRF was higher in hurdle preferred and FORE than in DJ preferred, FLAT, and FORE. For stiffness and RFD, hurdle preferred and FORE were higher than DJ preferred and FLAT. Hurdle jumps showed higher rectus femoris EMG activity than DJ did during preactivity and eccentric phases but lower activity during the concentric phase. Considering the type of landing, FLAT generally demonstrated the greatest EMG activity. During the concentric phase, DJ exhibited higher rectus femoris EMG activity. Biceps femoris activity was higher with hurdles in all the phases. Gastrocnemius showed the highest EMG activity during the concentric phase, and during the eccentric phase, hurdle preferred and FORE showed the highest results. In conclusion, the hurdle FORE technique was the most powerful type of jump.
HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH NONFUNCTIONING PITUITARY ADENOMAS UNDERGOING POSTOPERATIVE RADIATION THERAPY: A CASE-CONTROL STUDY.

OBJECTIVE Nonfunctioning pituitary adenomas (NFPAs) can be associated with significant morbidity including a compromised quality of life (QoL). Radiotherapy (RT) is listed as one of the contributing factors to QoL impairment in these patients, however the evidence supporting this association is scarce and conflicting. Here we evaluate health-related QoL (HRQoL) impairment in patients with NFPA and to what extent this is due to RT. METHODS HRQoL was evaluated with the short form-36 questionnaire (SF-36), which explores 8 domains pertaining physical, emotional, and mental well being. We assessed 50 patients with NFPA subjected to RT after pituitary surgery, and their results were compared to those from 127 subjects who had undergone surgery but not RT. Both groups were matched for age, sex, and metabolic and cardiovascular comorbidities. The SF-36 was applied a median of 72 months after RT in the group of cases and 78 months after the last surgical procedure in the control group. RESULTS Both groups scored equally low in the 8 areas explored by the survey. In a multiple linear regression model, age was significantly associated with worse physical health scores, whereas female sex was associated with worse general health perception and lower emotional role and physical role scores. The presence of a visual field defect was significantly associated with a worse social role functioning score. CONCLUSION QoL in patients with NFPAs is significantly compromised in most scales evaluated by the SF-36 survey. However, RT itself does not affect QoL.
PREVENTION AND MANAGEMENT OF INSULIN-ASSOCIATED HYPOGLYCEMIA IN HOSPITALIZED PATIENTS.

OBJECTIVE To determine whether appropriate therapeutic changes in insulin doses are made to prevent and manage insulin-associated hypoglycemic events in non-critically ill hospitalized patients. METHODS This retrospective study was conducted in hospitalized adults on medical or surgical floors with insulin-associated hypoglycemia, excluding treatment with insulin infusions, insulin pumps, and parenteral nutrition. The first hypoglycemic event after 48 hours of admission was the index event. Over the 1-year study period, a total of 457 insulin-associated hypoglycemic events were included as index events. RESULTS An indication for an insulin dose adjustment was identified in 32 and 42% of patients on day -2 and day -1, respectively, before the index hypoglycemic event, of which 35 and 55%, respectively, had an insulin dose reduction ≥10%. Following the hypoglycemic event, 44% of patients had an insulin dose reduction of ≥20%. Therapeutic reduction of the total daily insulin dose by ≥20% was associated with increased odds of normoglycemia and lower odds of hyperglycemia but was not associated with lower odds of recurrent hypoglycemia on the day following the index hypoglycemic event. There was a high prevalence of hypoglycemic risk factors in this population, with kidney disease and nil per os status being the most prevalent contributing factors. CONCLUSION Adherence to the current practice recommendation to reduce insulin doses in patients with borderline hypoglycemia and following overt hypoglycemia was modest. Further studies are needed to understand the associated risks and to define appropriate therapeutic changes for insulin treated patients with borderline and overt hypoglycemia. ABBREVIATIONS AKI = acute kidney injury BG = blood glucose CKD = chronic kidney disease ESRD = end-stage renal disease ICU = intensive care unit NPH = Neutral Protamine Hagedorn NPO = nil per os OR = odds ratio TDD = total daily dose.
Relationship Between Performance Variables and Baseball Ability in Youth Baseball Players

Abstract Nakata, H, Nagami, T, Higuchi, T, Sakamoto, K, and Kanosue, K. Relationship between performance variables and baseball ability in youth baseball players. J Strength Cond Res 27(10): 2887–2897, 2013—The present study investigated the relationship of performance variables and anthropometric measurements on baseball ability in 164 youth baseball players (age: 6.4–15.7 years). To evaluate their baseball performance, ball speeds in pitching and batting were recorded and kinetic energies of the pitched and hit balls were calculated. To record anthropometric and physical fitness characteristics, height and weight were measured and a battery of physical fitness tests covering standing long jump, side steps, sit-ups, 10-m sprint, trunk flexion, back strength, and grip strengths of both hands were conducted. The results of a multiple regression analysis revealed several significant predictors: age, body mass index (BMI), standing long jump, 10-m sprint, and grip strength for pitched ball kinetic energy and age, BMI, standing long jump, and back strength for hit ball kinetic energy. This study provides scientific evidence that relates certain specific physical performance tests and body characteristics with high achievement in the actual performance of pitching and batting. Youth players, their parents, coaches, and trainers would benefit by addressing these characteristics when planning training programs to improve the baseball performance of youth players.
Trichomonas vaginalis: Clinical relevance, pathogenicity and diagnosis

Abstract Trichomonas vaginalis is the etiological agent of trichomoniasis, the most prevalent non-viral sexually transmitted disease worldwide. Trichomoniasis is a widespread, global health concern and occurring at an increasing rate. Infections of the female genital tract can cause a range of symptoms, including vaginitis and cervicitis, while infections in males are generally asymptomatic. The relatively mild symptoms, and lack of evidence for any serious sequelae, have historically led to this disease being under diagnosed, and under researched. However, growing evidence that T. vaginalis infection is associated with other disease states with high morbidity in both men and women has increased the efforts to diagnose and treat patients harboring this parasite. The pathology of trichomoniasis results from damage to the host epithelia, caused by a variety of processes during infection and recent work has highlighted the complex interactions between the parasite and host, commensal microbiome and accompanying symbionts. The commercial release of a number of nucleic acid amplification tests (NAATs) has added to the available diagnostic options. Immunoassay based Point of Care testing is currently available, and a recent initial evaluation of a NAAT Point of Care system has given promising results, which would enable testing and treatment in a single visit.
Health effects of concentrated ambient air particulate matter (CAPs) and its components

We review literature that provides insights on health-related effects observed in laboratory-based inhalation studies in humans and laboratory animals using concentrated ambient air particulate matter (CAPs) in the fine, thoracic coarse, and ultrafine size ranges. The CAPs studies are highly informative on the health effects of ambient air particulate matter (PM) because they represent realistic PM exposure mixtures. When PM components are also analyzed and regressed against the effects, they can sometimes be used to identify influential individual components or source-related mixtures responsible for the effects. Such CAPs inhalation studies are analogous to epidemiological studies of human populations for which both health-related effects were observed and PM composition data were available for multi-pollutant regression analyses or source apportionment. Various acute and chronic health-related effects have occurred in short- and long-term CAPs inhalation studies in the cardiovascular, nervous, hepatic, and pulmonary systems, as well as changes in markers of the metabolic syndrome, and many correspond to effects associated with ambient air PM exposures in epidemiological studies. In addition, many CAPs studies have been conducted in coordination with in vitro studies that have identified biomarkers indicative of the underlying biological mechanisms that account for the responses.
Intergenerational Roots of Early Onset Substance use

This study examines intergenerational continuity in drug use across three generations of respondents in the same family. The data are from the Rochester Intergenerational Study, an ongoing, prospective, multi-generational investigation using a community-based sample. Our findings indicate that there is intergenerational continuity in drug use for Generation 2, or G2 daughters, but not sons, of G1 mothers. Use by G3 is significantly influenced by both G2 mothers and G1 grandmothers. However, for children of G2 fathers, neither prior generation's substance use is significantly related to G3 use. There is some indication that the absence of an effect from G2 fathers to G3 drug use is due to the number of nonresident fathers in the sample.
Toxicological and epidemiological studies of cardiovascular effects of ambient air fine particulate matter (PM2.5) and its chemical components: Coherence and public health implications

Abstract Recent investigations on PM2.5 constituents’ effects in community residents have substantially enhanced our knowledge on the impacts of specific components, especially the HEI-sponsored National Particle Toxicity Component (NPACT) studies at NYU and UW-LRRI that addressed the impact of long-term PM2.5 exposure on cardiovascular disease (CVD) effects. NYU’s mouse inhalation studies at five sites showed substantial variations in aortic plaque progression by geographic region that was coherent with the regional variation in annual IHD mortality in the ACS-II cohort, with both the human and mouse responses being primarily attributable to the coal combustion source category. The UW regressions of associations of CVD events and mortality in the WHI cohort, and of CIMT and CAC progression in the MESA cohort, indicated that had stronger associations with CVD-related human responses than OC, EC, or Si. The LRRI’s mice had CVD-related biomarker responses to . NYU also identified components most closely associated with daily hospital admissions (OC, EC, Cu from traffic and Ni and V from residual oil). For daily mortality, they were from coal combustion (, Se, and As). While the recent NPACT research on PM2.5 components that affect CVD has clearly filled some major knowledge gaps, and helped to define remaining uncertainties, much more knowledge is needed on the effects in other organ systems if we are to identify and characterize the most effective and efficient means for reducing the still considerable adverse health impacts of ambient air PM. More comprehensive speciation data are needed for better definition of human responses.
A study of musculoskeletal strain experienced by nurses

This study was conducted to determine whether the activities performed by fourteen registered nurses subjected the different body joints to varied levels of musculoskeletal strain. While the present study confirmedthe presence of significant lower back problems among nurses, the findings strongly suggest that nurses experienced significant musculoskeletal strain in other body parts/joints. In general, the lower back, neck, shoulder and wrist/hand recorded the highest scores in terms of frequency and severity of musculoskeletal strain. Discomfort increased significantly during the course of time for all body parts. A practical method was proposed for the evaluation of musculoskeletal discomfort on the basis of the Borg scale. The 0-2 range is suggested as a green zone where no action is required. The 3-5 is presented as a yellow zone where caution should be in place and an action plan should be formulated to monitor the jobs in question in the intermediate and long terms. This zone is preserved for cumulative-based ergonomic problems. Finally, the 6-10 range should be regarded as a red zone where an immediate action should be in place because musculoskeletal troubles are around the corner and could occur any time. Again, the red zone is expected to cover acute-based ergonomic deficiencies.
The compartmentalization and translocation of the sphingosine kinases: Mechanisms and functions in cell signaling and sphingolipid metabolism

Members of the sphingosine kinase (SK) family of lipid signaling enzymes, comprising SK1 and SK2 in humans, are receiving considerable attention for their roles in a number of physiological and pathophysiological processes. The SKs are considered signaling enzymes based on their production of the potent lipid second messenger sphingosine-1-phosphate, which is the ligand for a family of five G-protein-linked receptors. Both SK1 and SK2 are intracellular enzymes and do not possess obvious membrane anchor domains within their primary sequences. The native substrates (sphingosine and dihydrosphingosine) are lipids, as are the corresponding products, and therefore would have a propensity to be membrane associated, suggesting that specific membrane localization of the SKs could affect both access to substrate and localized production of product. Here, we consider the emerging picture of the SKs as enzymes localized to specific intracellular sites, sometimes by agonist-dependent translocation, the mechanism targeting these enzymes to those sites, and the functional consequence of that localization. Not only is the signaling output of the SKs affected by subcellular localization, but the role of these enzymes as metabolic regulators of sphingolipid metabolism may be impacted as well.