Miracle-dz/UniFAR-FTUs huggingface dataset:
A novel algorithm with IM-LSI index for incremental maintenance of materialized view

The ability to afford decision makers with both accurate and timely consolidated information as well as rapid query response times is the fundamental requirement for the success of a Data Warehouse. To provide fast access, a data warehouse stores materialized views of the sources of its data. As a result, a data warehouse needs to be maintained to keep its contents consistent with the contents of its data sources. Incremental maintenance is generally regarded as a more efficient way to maintain materialized views in a data warehouse The view has to be maintained to reflect the updates done against the base relations stored at the various distributed data sources. The proposed approach contains two modules namely, (1) materialized view selection(MVS) and (2) maintenance of materialized view. (MMV). In recent times, several algorithms have been proposed for keeping the views up-to-date in response to the changes in the source data. Therefore, we present an improved algorithm for MVS and MMV using IM-LSI(Itemset Mining using Latent Semantic Index) algorithm. selection of views to materialize using the IM(Itemset Mining) algorithm method to overcome the problem resulting from conventional view selection algorithms and then we consider the maintenance of materialized views using LSI. For the justification of the proposed algorithm, we reveal the experimental results in which both time and space costs better than conventional algorithms.
Micro(mi)RNA expression profile of breast cancer epithelial cells treated with the anti-diabetic drug metformin: Induction of the tumor suppressor miRNA let-7a and suppression of the TGFβ-induced oncomiR miRNA-181a

An unexplored molecular scenario that might explain the inhibitory impact of the anti-diabetic drug metformin on the genesis of breast cancer relates to metformin’s ability to modulate the expression status of micro (mi)RNAs. We here report the first miRNA expression profiling of human epithelial breast cancer cells cultured in the presence of metformin. We conducted real-time transcription polymerase chain reaction (qRT-PCR) Arrays to quantitatively compare the expression profile of 88 cancer-related miRNA sequences before and after treatment of MCF-7 cells, which were used as well-differentiated, epithelioid cell controls, with graded concentrations of metformin. Metformin-treated MCF-7 cells notably exhibited up to 18-fold increases in miRNA lethal-7a (let-7a) expression compared with untreated control cells. We confirmed that MCF-7 cells undergoing epithelial-to-mesenchymal (EMT) transition in response to the cytokine TGFβ notably up-regulated (~5-fold) miRNA-181a expression and exhibited better mammosphere-forming capabilities. We then explored the ability of metformin to impede TGFβ-enhanced propensity of breast cancer stem cells to form mammospheres in a miRNA-181a-related manner. Remarkably, TGFβ treatment failed to up-regulate miRNA-181a expression in the presence of metformin, which was able to fully abrogate TGFβ-enhanced mammosphere-forming ability. In addition, metformin co-treatment fully prevented TGFβ-induced down-regulation of the tumor suppressor miRNA-96 (~10-fold). Metformin’s molecular functioning to prevent invasive breast cancer can be explained in terms of its previously unrecognized ability to efficiently up-regulate the tumor-suppressive miRNAs let-7a & miRNA-96 and inhibit the oncogenic miRNA-181a, thus epigenetically preserving the differentiated phenotype of mammary epithelium while preventing EMT-related cancer-initiating cell self-renewal.
The control system for the disruption stabilisation experiment in JET

A new control system for the control of rotating magnetic islands in the JET plasma is described. The flexibility required to the controller because of uncertainty and variability of the plasma model have imposed a digital implementation. To obtain the fast response required by the modes dynamic the controller is composed by a set of six DSPs working in parallel. Furthermore the controller is interfaced to other diagnostics systems in order to be able to adapt its action to different plasma conditions in real time.
General recognition models capable of integrating multiple sensors for different domains

Allowing robots to recognize activities through different sensors and re-using its previous experiences is a prominent way to program robots. For this, a recognition method needs to be proposed such that is transferable toward different domains independently of the used input sources. One key component for such generalization is the definition of common representations. In this paper, we present a flexible system to extract symbolic representations of the perceived scenario which adapts to different sensors, such as cameras, multi-modal skin, and robot joint data. These symbolic representations are used to generate a semantic reasoning engine to transfer the obtained models among different domains. To validate our system, first, our robot learns basic activities from observing a video for the task cutting bread. The extracted symbolic representations are later used as previous experiences to the robot, to allow on-line segmentation and recognition of the Kinesthetically demonstrated activities for the new packing oranges scenario with an average accuracy of 83%, thus demonstrating the generalization of our method.
Developing an Implementation Framework for the Future Internet using Software Deﬁned Networking and the Y-Comm Architecture

—The Future Internet will provide seamless connec- tivity via heterogeneous networks. The Y-Comm Architecture is a reference model that has been developed to build future mobile systems for heterogeneous environments. However, the emergence of Software Deﬁned Networking and Network Functional Vir- tualization will allow the implementation of advanced mobile architectures such as Y-Comm to be prototyped and explored in more detail. This paper proposes an implementation model for the Y-Comm architecture based on these mechanisms. A key component is the design of the Core Endpoint which connects various peripheral wireless networks to the core network. This paper also proposes the development of a Network Management Control Program which allows the management routines running in the Cloud to control the underlying networking infrastructure. The system being proposed is ﬂexible and modular and will allow current and future wireless technologies to be seamlessly integrated into the overall system.
Aβ and Aδ but not C‐fibres are involved in stroke related pain and allodynia: an experimental study in mice

Objectives Cerebral ischaemia is a leading cause of death and disability, including severe complications such as memory disturbance, palsy, and spasticity. Central post‐stroke pain (CPSP) is a complication of cerebral ischaemia, and is characterized clinically by spontaneous pain and attacks of allodynia and dysaesthesia. However, the detailed mechanisms of CPSP are not well established. Herein, we have examined alterations of the current stimulus threshold of primary afferent neurons or the nociceptive threshold against mechanical stimuli in mice receiving left middle cerebral artery occlusion (MCAO).
Sequence Communication: Tabulation of transthyretin (TTR) variants as of 1/1/2000

he past 10 years have been a remarkable period of discovery in the study of familial amyloidotic polyT neuropathy (FAP), a disease associated with the plasma protein transthyretin (TTR), whose 127-residue amino acid sequence is shown in Figure 1. Since TTR was frst identified in the extracellular deposits of patients with hereditary amyloidosis more than two decades ago, there have been an extraordinary number of reports detailing the existence of over 80 variant forms of the protein. It is quite remarkable that more than 30 of these variants have been identified within the past four years; the current rate of discovery suggests that many more mutations will be reported, as improved analytical methods are applied to the quest and as a wider patient population gains access to appropriate diagnostic services. While the vast majority of the reported TTR mutations are amyloidogenic, the precise cause(s) and mechanism(s) responsible for aberrant TTR subunit assembly (or misassembly) into amyloid fibrils remains undetermined. The genetic basis of the disease stems fiom single base nucleotide mutations that occur throughout the entire coding region of the TTR gene. The phenotypes of TTR-associated familial amyloidosis are varied, but common clinical features and ethnic origins have been noted among kinships afflicted with identical TTR mutations. This special article provides a compilation of the polymorphic forms of TTR, both pathologic and non-pathologic, which have been reported as of January 1,2000. This collection should facilitate the work of laboratory investigators and provide a guide to the literature for those who wish to gain familiarity with the field. TTR proteins are presented in tabular form, listed in ascending order according to the position ofthe variant amino acid. As is customary, the threeletter code for the residue present in the wild type protein appears on the left, followed by the position number and the three-letter code for the variant amino acid, e.g. , CyslOArg indicates that the residue cysteine (Cys) at position 10 is replaced by arginine (Arg) in the mutant protein. The corresponding genetic, biochemical, clinical and demographic information (as currently available) is summarized for each variant. Specifically, genetic mutation data (DNA base change) and resultant amino acid mass shifts (change in amino acid residue mass between wild type and variant at the position where the base substitution occurs) are listed. For the amyloidogenic variants, clinical features (phenotype) and world-wide distribution (geographic focusl ethnic origin) are detailed. Non-amyloidogenic proteins are shown in italicized print. The earliest report of the gene or protein mutation appears in Table 1. A comprehensive list of initial and subsequent references to each variant and
Association of Human Fetuin-A rs4917 Polymorphism With Obesity in 2 Cohorts

Background Previous studies have shown association of the multifunctional hepatic protein α2HS-glycoprotein/human fetuin A with insulin resistance, type 2 diabetes mellitus, metabolic syndrome, obesity, and atherosclerosis. Reports of contribution of α2HS-glycoprotein/human fetuin A rs4917 single-nucleotide polymorphism to the development of these pathologic processes are inconsistent. We aimed to investigate the association between variants of rs4917 and parameters of obesity, lipid status, the proinflammatory cytokine tumor necrosis factor α (TNF-α), adipokines (adiponectin, resistin), and insulin resistance in 2 cohorts. Methods Eighty-one healthy persons (cohort 1) and 157 patients with previous myocardial infarction (cohort 2) were included in this cross-sectional study. rs4917 Polymorphism was determined by the allele-specific KASP by design genotyping assays. Results In cohort 1, T-nucleotide carriers had lower low-density lipoprotein cholesterol levels compared with non-T carriers. The serum concentration of TNF-α was found to be higher carrying the non-T allele in cohort 1; however, this difference was not observed in cohort 2. In cohort 2, T carriers had lower body mass index and abdominal and waist circumferences than did non-T carriers. The T nucleotide was more frequent in nonobese than in obese patients (χ2 = 5.217, P = 0.022). Nonobese, nondiabetic T carriers still had lower body mass index and waist circumference than did non-T carriers. Conclusions Our data suggest that the T nucleotide in rs4917 is associated with more favorable lipid status among healthy persons (i.e., lower low-density lipoprotein cholesterol) and anthropologic parameters of obesity in cohort 2. The protective role of the T allele may also be associated with lower TNF-α levels found in healthy individuals.
Proteomic characterization of the acid tolerance response in Lactobacillus delbrueckii subsp. bulgaricus CAUH1 and functional identification of a novel acid stress-related transcriptional regulator Ldb0677.

To overcome the deleterious effects of acid stress, Lactobacillus delbrueckii subsp. bulgaricus (L. bulgaricus) elicits an adaptive response to acid stress. In this study, proteomics approach complemented by transcriptional analysis revealed some cellular changes in L. bulgaricus CAUH1 during acid adaptation. We observed an increase of glycolysis-associated proteins, promoting an optimal utilization of carbohydrates. Also, rerouting of the pyruvate metabolism to fatty acid biosynthesis was observed, indicating a possible modification of the cell membrane rigidity and impermeability. In addition, expression of ribosomal protein S1 (RpsA) was repressed; however, the expression of EF-Tu, EF-G and TypA was up-regulated at both protein and transcript levels. This suggests a reduction of protein synthesis in response to acid stress along with possible enhancement of the translational accuracy and protein folding. It is noteworthy that the putative transcriptional regulator Ldb0677 was 1.84-fold up-regulated. Heterologous expression of Ldb0677 was shown to significantly enhance acid resistance in host strain Lactococcus lactis. To clarify its role in transcriptional regulation network, the DNA-binding specificity of Ldb0677 was determined using bacterial one-hybrid and electrophoretic mobility shift assay. The identification of a binding motif (SSTAGACR) present in the promoter regions of 22 genes indicates that it might function as a major regulator in acid stress response in L. bulgaricus.
Archival Practices and the Making of “Memories”

Following Derrida (1995), our article explores the relationship between archival practices and archival documents on the assumption that “archivization produces as much as it records the event” (Derrida 1995, 17). On this approach, archival practices are understood as non-innocent practices that, in the act of “preservation,” help make specific “memories” at the expense of others (Barad 2007; Derrida 1995; Foucault 1972). We take up this issue in relation to the curation of social science quantitative research data and argue that the ontological identity of data is constituted through historically- and culturally-specific data curation practices including data cleaning, data anonymization, and metadata preparation.
Further results on the experimental evaluation of iterative learning control algorithms for non-minimum phase plants

This paper builds on previous work in which simple structure ILC algorithms were experimentally evaluated on a non-minimum phase plant. The phase-lead update law, the most promising of those implemented, is examined using an established performance criterion. The use of a forgetting factor is found to overcome the problem of instability, but at the expense of increased final error. This is verified through experimentation. The phase-lead algorithm is improved using additional phase-leads to remove the instability and improve convergence and final error. This technique is generalized to produce an optimization routine which leads to greatly improved results. The learning law utilizing the plant adjoint is found to fit naturally into this framework and practical results are presented to compare their respective performance. This algorithm, which requires a model of the plant, is reformulated into one which does not. Results are presented using this technique and practical guidelines are produced and tested to improve its performance. A simple method of increasing the learning at higher frequencies is proposed and practical limitations are addressed and verified experimentally. All the algorithms tested are compared with respect to their performance, practicality and robustness.
A Biometric Key Establishment Protocol for Body Area Networks

Current advances in semiconductor technology have made it possible to implant a network of biosensors inside the human body for health monitoring. In the context of a body area network (BAN), the confidentiality and integrity of the sensitive health information is particularly important. In this paper, we present an ECG (electrocardiogram)-signal-based key establishment protocol to secure the communication between every sensor and the control unit before the physiological data are transferred to external networks for remote analysis or diagnosis. The uniqueness of ECG signal guarantees that our protocol can provide long, random, distinctive and temporal variant keys. Biometric Encryption technique is applied to achieve the mutual authentication and derive a non-linkable session key between every sensor and the control unit. The correctness of the proposed key establishment protocol is formally verified based on SVO logic. Security analysis shows that our protocol can guarantee data confidentiality, authenticity and integrity. Performance analysis shows that it is a lightweight protocol.
Beyond ICA: robust sparse signal representations

In many applications it is necessary to perform some decomposition of observed signals or data in such a way that components have some special properties or structures such as statistical independence, sparsity, smoothness, nonnegativity, prescribed statistical distributions and/or specific temporal structure. In this paper we discuss cost functions whose minimization solve such problems and we present new properties that characterize optimal solutions for sparse representations. Especially, we discuss robust cost functions in order to find sparse representation of noisy signals. Furthermore, we discuss sub-band decomposition preprocessing to relax independence conditions for source signals.
High-Power and High-Linearity Photodetector Modules for Microwave Photonic Applications

We demonstrate hermetically packaged InGaAs/InP photodetector modules for high performance microwave photonic applications. The devices employ an advanced photodiode epitaxial layer known as the modified uni-traveling carrier photodiode (MUTC-PD) with superior performance in terms of output power and saturation. To further improve the thermal limitations, the MUTC-PDs were flip-chip bonded on high thermal conductivity substrates such as Aluminum Nitride (AlN) and Diamond. Modules using chips with active area diameters of 40, 28, and 20 μm were developed. The modules demonstrated a 3-dB bandwidth ranging from 17 GHz up to 30 GHz. In continuous wave mode of operation, very high RF output power was achieved with 25 dBm at 10 GHz, 22 dBm at 20 GHz, and 17 dBm at 30 GHz. In addition, the linearity of the modules was characterized by using the third order intercept point (OIP3) as a figure of merit. Very high values of OIP3 were obtained with 30 dBm at 10 GHz, 25 dBm at 20 GHz and more than 20 dBm at 30 GHz. Under short pulse illumination conditions and by selectively filtering the 10 GHz frequency component only, a saturated power of >21 dBm was also measured. A very low AM-to-PM conversion coefficient was measured, making the modules highly suitable for integration in photonic systems for ultralow phase noise RF signal generation.
Proposed continuous wave energy recovery operation of an x-ray free electron laser

Commissioning of two large coherent light facilities (XFELs) at SLAC and DESY should begin in 2008 and 2011, respectively. In this paper we look further into the future, hoping to answer, in a very preliminary way, two questions. First: What will the next generation of XFEL facilities look like? Believing that superconducting technology offers advantages such as high quality beams with highly populated bunches, the possibility of energy recovery and higher overall efficiency than warm technology, we focus this preliminary study on the superconducting option. From this belief the second question arises: What modifications in superconducting technology and in the machine design are needed, as compared to the present DESY XFEL, and what kind of research and development program should be proposed to arrive in the next few years at a technically feasible solution with even higher brilliance and increased overall conversion of ac power to photon beam power? In this paper we will very often refer to and profit from the DESY XFEL design, acknowledging its many technically innovative solutions.
Evaluating Linkages of Weather Patterns and Water Quality Responses in South Florida Using a Synoptic Climatological Approach

AbstractCoastal ocean ecosystems are impacted by atmospheric conditions and events, including episodic severe systems such as hurricanes as well as more regular seasonal events. The complexity of the atmosphere–ocean relationship makes establishing concrete connections difficult. In this paper, this relationship is assessed through synoptic climatological methods, a technique well established in applied climatological research but heretofore rarely used in assessing coastal ocean water quality and ecological status. Historical sea level pressure data are used to define 10 circulation patterns across the southeastern United States and adjacent Gulf of Mexico, based on the spatial pattern of sea level pressure, which can then be associated with the presence of cyclones, precipitation, and wind stress. The frequency of these patterns, and their deviation from climatological means, is then compared with Sea-Viewing Wide Field-of-View Sensor (SeaWiFS) chlorophyll observations over the Florida Bay and south Flo.
Differentiation-Induced Cultured Podocytes Express Endocytically Active Megalin, a Heymann Nephritis Antigen

Background/Aims: Megalin is a multiligand endocytic receptor expressed in a number of epithelia. In the Lewis rat kidney, podocytes, as well as proximal tubule cells, express megalin that acts as a pathogenic antigen for Heymann nephritis (HN), an experimental model of membranous nephropathy. To obtain a tool to investigate the molecular mechanisms of megalin-mediated endocytosis and the pathogenesis of HN, we examined whether a differentiation-inducible mouse podocyte cell line expressed endocytically active megalin. Methods: Immunofluorescence and immunoprecipitation analyses with an anti-rat megalin antibody were carried out to investigate whether megalin was expressed in the differentiated and undifferentiated podocytes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis was performed to elucidate whether the cells synthesize megalin mRNA. 125I-labeled receptor-associated protein (RAP), an endocytic ligand for megalin, was used for cellular internalization and degradation assays. Results: Immunofluorescence, immunoprecipitation and RT-PCR analyses revealed that megalin was synthesized in both differentiated and undifferentiated cells and localized to the cell surfaces. Effective endocytosis of RAP via megalin was shown under the differentiated condition. Conclusion: Endocytically active megalin is expressed in differentiation-induced cultured podocytes. This cell line could be a useful tool for studies on megalin-mediated endocytosis and the pathogenesis of HN.