Miracle-dz/UniFAR-FTUs huggingface dataset:
Sequential Information Flow and Real-Time Diagnosis of Swiss Inflation: Intra-Monthly DCF Estimates for a Low-Inflation Environment

The timely release of macroeconomic data imposes a distinct structure on the panel: the clustering and sequential ordering of real and nominal variables. We call this orderly release of economic data sequential information flow. The ordered panel generates a new class of restrictions that are helpful in interpreting the real-time estimates of monthly core inflation through the identification of turning points and structural shocks. After establishing the sought-after properties (of smoothness, stability, and forecasting) for core inflation, we turn to the discussion of real-time diagnosis for a low inflation environment. This is done in the context of weekly estimates of Swiss inflation. The intra-monthly estimates for core inflation find that it is worthwhile to update this measure at least twice a month.
Topographic organization ot spinal ana trigeminal somatosensory pathways to the rat parabrachial and Kölliker—fuse nuclei

We examined the organization of somatosensory projections to the parabrachial (PB) and Kölliker‐Fuse (KF) nuclei by employing the retrograde and anterograde axonal transport of Fluorogold and Phaseolus vulgaris–leucoagglutinin (PHA‐L), respectively. Small PHA‐L injections were made into different parts of the spinal trigeminal complex, including the paratrigeminal nucleus, and into different segments and laminae of the spinal dorsal horn. The subnuclear distribution of axonal labeling in the PB and KF was mapped with a camera lucida.
Cytoplasmic O‐glycosylation prevents cell surface transport of E‐cadherin during apoptosis

Cellular adhesion is regulated by members of the cadherin family of adhesion receptors and their cytoplasmic adaptor proteins, the catenins. Adhesion complexes are regulated by recycling from the plasma membrane and proteolysis during apoptosis. We report that in MCF‐7, MDA‐MB‐468 and MDCK cells, induction of apoptosis by agents that cause endoplasmic reticulum (ER) stress results in O‐glycosylation of both β‐catenin and the E‐cadherin cytoplasmic domain. O‐glycosylation of newly synthesized E‐cadherin blocks cell surface transport, resulting in reduced intercellular adhesion. O‐glycosylated E‐cadherin still binds to β‐ and γ‐catenin, but not to p120‐catenin. Although O‐glycosylation can be inhibited with caspase inhibitors, cleavage of caspases associated with the ER or Golgi complex does not correlate with E‐cadherin O‐glycosylation. However, agents that induce apoptosis via mitochondria do not lead to E‐cadherin O‐glycosylation, and decrease adhesion more slowly. In MCF‐7 cells, this is due to degradation of E‐cadherin concomitant with cleavage of caspase‐7 and its substrate poly(ADP‐ribose) polymerase. We conclude that cytoplasmic O‐glycosylation is a novel, rapid mechanism for regulating cell surface transport exploited to down‐regulate adhesion in some but not all apoptosis pathways.
The Epstein–Barr virus lytic program is controlled by the co‐operative functions of two transactivators

The propagation of herpesviruses has long been viewed as a temporally regulated sequential process that results from the consecutive expression of specific viral transactivators. As a key step in this process, lytic viral DNA replication is considered as a checkpoint that controls the expression of the late structural viral genes. In a novel genetic approach, we show that both hypotheses do not hold true for the Epstein–Barr virus (EBV). The study of viral mutants of EBV in which the early genes BZLF1 and BRLF1 are deleted allowed a precise assignment of the function of these proteins. Both transactivators were absolutely essential for viral DNA replication. Both BZLF1 and BRLF1 were required for full expression of the EBV proteins expressed during the lytic program, although the respective influence of these molecules on the expression of various viral target genes varied greatly. In replication‐defective viral mutants, neither early gene expression nor DNA replication was a prerequisite for late gene expression. This work shows that BRLF1 and BZLF1 harbor distinct but complementary functions that influence all stages of viral production.
Comparison of diameter and perimeter methods for tumor volume calculation.

PURPOSE Lesion volume is often used as an end point in clinical trials of oncology therapy. We sought to compare the common method of using orthogonal diameters to estimate lesion volume (the diameter method) with a computer-assisted planimetric technique (the perimeter method). METHODS Radiologists reviewed 825 magnetic resonance imaging studies from 219 patients with glioblastoma multiforme. Each study had lesion volume independently estimated via the diameter and perimeter methods. Cystic areas were subtracted out or excluded from the outlined lesion. Inter- and intrareader variability was measured by using multiple readings on 48 cases. Where serial studies were available in noncystic cases, a mock response analysis was used. RESULTS The perimeter method had a reduced interreader and intrareader variability compared with the diameter method (using SD of differences): intrareader, 1.76 mL v 7.38 mL (P < .001); interreader, 2.51 mL v 9.07 mL (P < .001) for perimeter and diameter results, respectively. Of the 121 noncystic cases, 23 had serial data. In six (26.1%) of those 23, a classification difference occurred when the perimeter method was used versus the diameter method. CONCLUSION Variability of measurements was reduced with the computer-assisted perimeter method compared with the diameter method, which suggests that changes in volume can be detected more accurately with the perimeter method. The differences between these techniques seem large enough to have an impact on grading the response to therapy.
Electrical grounding and cathodic protection issues in large generating stations

The common bonding of underground structures to massive copper grounding gri creates problems for corrosion engineers and their attempts to provide cathodic protection to ferrous structures. This article discusses conflicts between the design and operation of copper and ferrous underground systems and presents alternatives. It describes the of a large electrical generating station with a bare copper grounding grid, typical of late-1960s construction practices.
A new approach to control flow checking without program modification

An approach to concurrent control flow checking that avoids performance and software compatibility problems while preserving a high error coverage and a low detection latency is proposed. The approach is called watchdog direct processing. Extensions of the basic method, taking into account the characteristics of complex processors, are also considered. The architecture of a watchdog processor based on the proposed method is described. Implementation results are reported for a watchdog designed for the Intel 80386sx microprocessor. <<ETX>>
Approaches to Political Commentary in Scandinavia

Abstract Political commentary is a contested genre that has attracted a great deal of attention in the Scandinavian public debate, whereas the scholarly literature on it is still in an initial phase. In order to strengthen future research, the present paper suggests a two-dimensional matrix indexing the research on Scandinavian political commentary along the dimensions text/context and descriptive/evaluative. The matrix enables us to see more clearly what we already know and where we lack knowledge. It enables us to see how each category can be developed, the interplay among them, and the obvious lack of textual, evaluative approaches. The author argues that a joint, cross-disciplinary engagement is necessary if we are to adequately understand the potentials and problems of political commentary.
Random Frequency PageRank

Info-boxes provide a summary of the most important meta-data relating to a particular entity described by aWikipedia article. However, many articles have no info-box or have info-boxes with only minimal information; furthermore, there is a huge disparity between the level of detail available for info-boxes in English articles and those for other languages. Wikidata has been proposed as a central repository of facts to try to address such disparities, and has been used as a source of information to generate info-boxes. However, current processes still rely on human intervention either to create generic templates for entities of a given type or to create a specific info-box for a specific article in a specific language. As such, there are still many articles of Wikipedia without info-boxes but where relevant data are provided by Wikidata. In this paper, we investigate fully automatic methods to generate info-boxes for Wikipedia from the Wikidata knowledge graph. The primary challenge is to create ranking mechanisms that provide an intuitive prioritisation of the facts associated with an entity. We discuss this challenge, propose several straightforward metrics to prioritise information in info-boxes, and present an initial user evaluation to compare the quality of info-boxes generated by various metrics.
qnrA in CTX-M-Producing Escherichia coli Isolates from France

ABSTRACT By PCR, we screened for qnr genes 112 clinical isolates of extended-spectrum β-lactamase-producing Escherichia coli collected from hospitals in France during 2004. For the first time, 7.7% of CTX-M-producing E. coli isolates presented a plasmid-mediated resistance to quinolones. All strains harbored a qnrA gene located on a sul1-type class 1 integron with similar structure to the In36 integron.
Participants’ and staffs’ evaluation of the Illness Management and Recovery program: a randomized clinical trial

Abstract Background: Psychoeducational interventions for people with severe mental illness are developed to enable them to manage their illness effectively to improve prognosis and recovery. Aim: The aim was to investigate the benefits and harms of the Illness Management and Recovery (IMR) program among people with severe mental illness in Denmark. IMR builds among other approaches on a psychoeducational approach. Methods: A randomized, multi-center, clinical trial of the IMR program compared with treatment as usual among 198 participants with schizophrenia or bipolar disorder investigating outcomes related to illness self-management assessed by the IMR scale, recovery, hope and participants’ satisfaction at the end of the 9 months intervention period. Results: No statistical differences were seen between the two groups regarding illness self-management, hope, recovery, or satisfaction with treatment. Conclusions: IMR appears not to be better than treatment as usual in any of the outcomes. Further studies with a longer follow-up period, better assessments of recovery and a systematic review of the existing trials are needed to assess if the program is effective.
FPGA Based Scalable Fixed Point QRD Core Using Dynamic Partial Reconfiguration

This work presents an FPGA based scalable fixed point QRD architecture based on Givens Rotation algorithm.The proposed QRD core utilizes an efficient pipelined and unfolded 2D MAC based systolic array architecture with dynamic partial reconfiguration(DPR) capability. An improved LUT based Newton-Raphson method is proposed for finding square root and inverse square root which helps in reducing the area by 71% and latency by 50%, while operating at a frequency 49% higher than the existing boundary cell architectures. The scalability of the QRD core is achieved using DPR which results in reduction in dynamic power and area utilization as compared to a static implementation. The proposed architecture is implemented on Xilinx Virtex-6 FPGA for any real matrices of size m × n where, 4 ≤ n ≤ 8 and m ≥ n by dynamically inserting or removing the partial modules. The evaluation results shows reduction in latency, area and power as compared to CORDIC based architectures. The proposed scalable QRD core is used for implementing a high performance adaptive equalizer(QRD-RLS Algorithm) used in mobile receiver's and the evaluation is done by transmitting BPSK symbols in the training mode.
Critical Design Features of Phenyl Carboxylate-Containing Polymer Microbicides

ABSTRACT Recent studies of cellulose-based polymers substituted with carboxylic acids like cellulose acetate phthalate (CAP) have demonstrated the utility of using carboxylic acid groups instead of the more common sulfate or sulfonate moieties. However, the pKa of the free carboxylic acid group is very important and needs careful selection. In a polymer like CAP the pKa is approximately 5.28. This means that under the low pH conditions found in the vaginal lumen, CAP would be only minimally soluble and the carboxylic acid would not be fully dissociated. These issues can be overcome by substitution of the cellulose backbone with a moiety whose free carboxylic acid group(s) has a lower pKa. Hydroxypropyl methylcellulose trimellitate (HPMCT) is structurally similar to CAP; however, its free carboxylic acids have pKas of 3.84 and 5.2. HPMCT, therefore, remains soluble and molecularly dispersed at a much lower pH than CAP. In this study, we measured the difference in solubility and dissociation between CAP and HPMCT and the effect these parameters might have on antiviral efficacy. Further experiments revealed that the degree of acid substitution of the cellulose backbone can significantly impact the overall efficacy of the polymer, thereby demonstrating the need to optimize any prospective polymer microbicide with respect to pH considerations and the degree of acid substitution. In addition, we have found HPMCT to be a potent inhibitor of CXCR4, CCR5, and dual tropic strains of human immunodeficiency virus in peripheral blood mononuclear cells. Therefore, the data presented herein strongly support further evaluation of an optimized HPMCT variant as a candidate microbicide.
XPLICIT T RUST M ODEL T OWARDS B ETTER S YSTEM S ECURITY

Trust is an absolute necessity for digital communications; but is often viewed as an implicit singular entity. The use of the internet as the primary vehicle for information exchange has made accountability and verifiability of system code almost obsolete. This paper proposes a novel approach towards enforcing system security by requiring the explicit definition of trust for all operating code. By identifying the various classes and levels of trust required within a computing system; trust is defined as a combination of individual characteristics. Trust is then represented as a calculable metric obtained through the collective enforcement of each of these characteristics to varying degrees. System Security is achieved by facilitating trust to be a constantly evolving aspect for each operating code segment capable of getting stronger or weaker over time.
Synaptic transmission and synchronous activity is disrupted in hippocampal slices taken from aged TAS10 mice

Synaptic transmission was studied in hippocampal slices from aged (12–14 months of age) TAS10 mice overexpressing the human form of the amyloid precursor protein harboring the Swedish mutation. A significant deficit in the input‐output relationship of glutamatergic synapses in the CA3–CA1 Schaffer collateral pathway was observed, while synaptic transmission in the medial perforant pathway of the dentate gyrus was comparatively preserved. Despite this deficit, relative levels of short‐ and long‐term synaptic plasticity in the CA1 region were similar to those observed in wildtype slices. Specifically, paired pulse facilitation, frequency facilitation (at frequencies of 1, 5, and 10 Hz), and long‐term potentiation induced by a theta burst stimulation paradigm were all normal in the CA3–CA1 synapses of TAS10 hippocampal slices. However, synchronized network activity induced by bath application of 4‐aminopyridine (4‐AP) was compromised. Thus, the frequency of synchronous events induced by 100 μM 4‐AP was significantly lower in TAS10 hippocampal slices (inter‐event interval: WT, 2.4 ± 0.6 s; TAS10, 6.9 ± 1.7 s). To study γ‐aminobutyric acid (GABA)ergic synaptic transmission NBQX (20 μM) and D‐AP5 (50 μM) were added in order to isolate bicuculline‐sensitive GABA‐mediated synchronous network activity. The GABAergic network activity was not significantly different from wildtype in terms of frequency. This study suggests that the deficit in glutamatergic synaptic transmission observed in the TAS10 hippocampal slices, may be coupled with alterations in synchronous network activity, which in turn would lead to deficient information processing. © 2004 Wiley‐Liss, Inc.
Play model for “evaluation of self-concept of children with cancer”

Background: Childhood cancers are fatal diseases which cause intense stress and traumatic situations for the ones who experience those diseases. This kind of an emotionally hard life may create some hardships for developing self-concept. The aim of the study is to put forth the self-exposure of a school-age child by using plays. Materials and Methods: Six play sessions had been carried out in June-August 2011. As a searching pattern, interpretive case study method was used. The research consisted of six children with cancer, aged between 9 and 12 years. The research was conducted in a public hospital in children oncology service. Results: The assessment of data was realized in two stages. The first one was examining the data; the other stage was the content analysis that has been constructed after the play sessions as "Nursing Intervention: Play Model. " In the newly formed model, nine themes had been found: (a) expressing good memories, (b) control, (c) problem-solving ability, (d) relations, (e) aggressive behaviors, (f) regression, (g) good-bad, (h) trauma, and (i) anxiety. Conclusions: The self-concept of the school-age child needs to be supported. It has been submitted that the themes can be supportive for the prospective nursing models concerning child′s self-exposure. It has been suggested that the themes produced by "Nursing Intervention: Play Model" can be used while planning, implementation, and assessment of the nursing care.
Expressed emotion in eating disorders assessed via self-report: an examination of factors associated with expressed emotion in carers of people with anorexia nervosa in comparison to control families.

OBJECTIVE High expressed emotion (EE) has been linked to outcome in anorexia nervosa (AN). Traditional interview measures of EE require considerable resources. The aim was to compare EE, measured with a self report tool, in parents of people with AN (carers; N = 151) with that of parents of healthy people (controls; N = 93), and to explore factors associated with EE. METHOD A cross-sectional design was used to assess EE (Family Questionnaire) and psychological distress (Hospital Anxiety and Depression Scale). RESULTS Over 60% (96/151) of carers showed high emotional over-involvement (EOI) compared with 3% (3/93) of controls, whereas 47% (71/151) of carers showed high criticism (CC) compared with 15% (14/93) of controls. The most significant variable related to CC was "negative/difficult behaviors," and anxiety, for EOI. CONCLUSION The FQ was sensitive both to CC and EOI. Interventions aimed at reducing EE may need to focus on decreasing carers' anxiety and teaching skills to moderate difficult behaviors.
SINGLE SENSOR SOURCE SEPARATION BASED ON WIENER FILTERING AND MULTIPLE WINDOW STFT

The aim of this paper is to investigate the use of multiresolution framework for single sensor source separation based on pseudo-Wiener filtering. We propose a scheme in which the signal is iteratively split in target sources and a residual. Each target source is modeled as the sum of elementary components with known Power Spectral Densities (PSDs). The approach boils down to perform a non negative decomposition of the spectra of the observed signal in a given frame onto the dictionnary of known PSDs. The resolution of the PSDs (and hence the frame length) is changed at each iteration of the algorithm. The decomposition into sources plus residual is done thanks to a confidence measure based on the Fisher information matrix of the expansion coefficients. After theoretical developments we compare the mono and multiresolution approaches and a set of audio examples.
Evaluation of The Effect of Salinity on Some Physiological and Phenological Traits in Durum Wheat Cultivars

Makarnalik bugday cesitlerine bazi fizyolojik ve fenolojik ozellikleri uzerinde tuzluk etkisini degerlendirmek icin, deneme Tesaduf Bloklar Deneme Desenine gore uc tekrarlamali olarak kurulmustur. Denemede kontrol dahil 2 tuz seviyesi (60, 120 mM) ve 10 makarnalik bugday cesidi (Boomer, PGS, 71135, 61130, 605, C1351, KND1000, KDM, Haurani ve G1252) kullanilmistir. Kok uzama suresi, basaklanma ve olgunlasma zamani, bayrak yapraginin klorofil icerigi ve floresani gibi ozellikler olculmustur. Arastirma sonuclarina gore; tuzluluk ve cesitlerin etkilesiminin sadece basaklanma suresi bakimindan onemli oldugu bulunmustur. Hem 61130 hem de PGS cesitlerinde basaklanma suresi tuzlulugun artisina bagli olarak artis gostermistir. PSG cesidi daha uzun bir olgununlama suresine sahip iken, Boomer cesidi en dusuk olgunlasma suresine sahip olmustur. Kok uzama suresi incelenecek olursa, 605 bugday cesiti en dusuk ve 61130 bugday cesiti ise en yuksek kok uzama suresine sahip olmuslardir. Tuzluluk ve cesitlerin etkilesimi bayrak yapragi klorofil icerigi bakimindan onemsiz bulunmus ancak, bayrak yapragi klorofil floresan bakimindan onemli (FV / FM) olarak saptanmistir. C1352 ve 71135 cesitlerinde bayrak yapragi klorofil icerigi sirasiyla en yuksek ve en dusuk olarak saptanmistir.
Randomized controlled trial on the impact of early-life intervention with bifidobacteria on the healthy infant fecal microbiota and metabolome.

Background: Early-life colonization of the intestinal tract is a dynamic process influenced by numerous factors. The impact of probiotic-supplemented infant formula on the composition and function of the infant gut microbiota is not well defined.Objective: We sought to determine the effects of a bifidobacteria-containing formula on the healthy human intestinal microbiome during the first year of life.Design: A double-blind, randomized, placebo-controlled study of newborn infants assigned to a standard whey-based formula containing a total of 107 colony-forming units (CFU)/g of Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium longum, B. longum subspecies infantis (intervention), or to a control formula without bifidobacteria (placebo). Breastfed controls were included. Diversity and composition of fecal microbiota were determined by 16S ribosomal RNA gene amplicon sequencing, and metabolite profiles were analyzed by ultrahigh-performance liquid chromatography-mass spectrometry over a period of 2 y.Results: Infants (n = 106) were randomly assigned to either the interventional (n = 48) or placebo (n = 49) group; 9 infants were exclusively breastfed throughout the entire intervention period of 12 mo. Infants exposed to bifidobacteria-supplemented formula showed decreased occurrence of Bacteroides and Blautia spp. associated with changes in lipids and unknown metabolites at month 1. Microbiota and metabolite profiles of intervention and placebo groups converged during the study period, and long-term colonization (24 mo) of the supplemented Bifidobacterium strains was not detected. Significant differences in microbiota and metabolites were detected between infants fed breast milk and those fed formula (P < 0.005) and between infants birthed vaginally and those birthed by cesarean delivery (P < 0.005). No significant differences were observed between infant feeding groups regarding growth, antibiotic uptake, or other health variables (P > 0.05). Conclusion: The supplementation of bifidobacteria to infant diet can modulate the occurrence of specific bacteria and metabolites during early life with no detectable long-term effects. This trial was registered at germanctr.de as DRKS00003660.