Miracle-dz/UniFAR-FTUs huggingface dataset:
Transplantation of mesenchymal stem cell sheet to treat acute hind-limb ischemia: A preclinical study

Introduction: Mesenchymal stem cell (MSC) transplantation has been reported as a promising therapy for acute limb ischemia (ALI). However, the treatment efficacy is limited to only certain improvements. Therefore, this study aims to improve the treatment efficacy of MSC transplantation through the use of MSC sheets produced from MSCs' cultured in fibrin scaffold (Fi-MSCs) in ALI models. Methods: MSCs were isolated and expanded from human umbilical cord tissue. The fibril scaffold was produced from human umbilical cord blood. Fi-MSCs were prepared by mixing MSCs with fibril according to a published protocol, and the Fi-MSC sheets were implanted directly into ligated and transected sites in the hind limbs of ischemic models (treatment group — group I). The results were compared with that of the control group (group II) in which mice were injected with saline. The treatment efficacy was recorded and evaluated through the following assays: limb morphology, SpO2, blood perfusion, angiogenesis, and histological morphology on days 7, 14, and 28 after treatment. Results: The results indicate that the transplantation of Fi-MSC sheets positively affected the acute ischemia hind-limb mouse models. On day 7 post-transplantation, the SpO2 index recorded at feet in group I (treatment) significantly increased from 79.24% + 1.43% to 89.40% + 1.65% (p-value < 0.05), while in group II (control), the SpO2 index slightly increased from 76.52% + 1.63% to 77.00 + 1.15 (p-value > 0.05). Besides, there were 60.00% (auto-recovery), 13.33%, and 26.67% mice at damage grades 0, I, and II, respectively, in the control group compared to 80%, 20%, and 0% mice at damage grades 0, I, and II, respectively. Moreover, in group I, all mice showed improved blood reperfusion, neovascular, and repaired muscle tissue compared to group II. Conclusion: Fi-MSC sheet transplantation positively reduced injury and improved blood perfusion ALI in the Swiss mouse model.
Comparison between the tie-over and Karydakis procedure in chronic sacrococcygeal pilonidal sinus

Background and aims: Pilonidal sinus in the sacrococcygeal region is a disease with high postoperative morbidity and discomfort for the patient. Although there are various therapeutic modalities to manage these patients, there is still controversy about choosing the best surgical technique to decrease the recurrence rate, patient discomfort, and duration of disability after surgery. The present study aimed to compare the results obtained from two surgery methods including tie-over procedure (TOP) and Karydakis procedure (KP) for the treatment of sacrococcygeal pilonidal sinus. Methods: In this single-blind clinical trial, 70 patients with the diagnosis of pilonidal sinus disease were divided into two equal groups (n=35 each) and treated randomly with surgical excision and TOP or KP by the same surgeon in the Kashani educational hospital in Shahrekord, Iran from 2009 and 2011. The patients were followed up until December 2019. Results: According to the results, after excision of sacrococcygeal pilonidal sinus, the primary closure of the wound by tie-over sutures had better results than KP in order of pain sore during the first month after surgery (P < 0.001), duration of disability (P < 0.001), wound repair time (P < 0.001), and patient satisfaction (P = 0.019). Conclusion: Our results showed TOP was a better procedure compared to KP for the treatment of chronic pilonidal sinus due to higher acceptance results in patients undergoing surgery.
CD8 T Cell Induction to Skin Viral Proteins NKT Cells Inhibit Antigen-Specific Effector

We recently demonstrated that CD1d-restricted NKT cells resident in skin can inhibit CD8 T cell-mediated graft rejection of human papillomavirus E7-expressing skin through an IFN- g –dependent mechanism. In this study, we examined the role of systemically derived NKT cells in regulating the rejection of skin grafts expressing viral proteins. In lymph nodes draining transplanted skin, Ag-speciﬁc CD8 T cell proliferation, cytokine production, and cytotoxic activity were impaired by NKT cells. NKT cell suppression was mediated via CD11c + dendritic cells. Inhibition of CD8 T cell function did not require Foxp3 + regulatory T cells or NKT cell-secreted IFN- g , IL-10, or IL-17. Thus, following skin grafting or immunization with human papillomavirus-E7 oncoprotein, NKT cells reduce the capacity of draining lymph node-resident APCs to cross-present Ag to CD8 T cell precursors, as evidenced by impaired expansion and differentiation to Ag-speciﬁc CD8 T effector cells. Therefore, in the context of viral Ag challenge in the skin, systemic NKT cells limit the capacity for effective priming of adaptive immunity. The Journal of Immunology , 2011, 187: 000–000. cells in of factor-beta myeloid effector
JM-JABF210113 688..697

Introduction Social determinants of health (SDoH), including food insecurity, housing instability, and financial hardship, are common in the United States, disproportionately impact vulnerable populations, and are associatedwith poor health outcomes. One in 8 US households are food insecure, 0.2% of US adults are homeless, and 12%are living inpoverty. Food, housing, andfinancial insecurities are more common among women, African Americans, younger adults, and thosewith lower education or chronic conditions. Food insecurity is independently associated with obesity, peripheral artery disease, hypertension, hyperlipidemia, diabetes, medication underuse, and overall poor health. Both food insecurity and housing instability are associated with sleep disorders, social isolation, cardiovascular disease, and poor overall physical and mental health. There is extensive evidence of the negative effects of financial hardship and poverty on health and access to care. Poor health outcomes, financial hardship, and food insecurity are worse in rural areas than urban areas, although mechanisms differ. Poor functional capacity is a commonphysical limitation among the chronically ill and amajor risk factor for mortality. Exercise capacity, a measure of Submitted 7 January 2021; revised 25 February 2021; accepted 11 March 2021. From University of Vermont, Burlington, VT (LNB, AMC, KK, BL); Clinton Medical Associates, University of Rochester, Rochester, NY (LNB, AMC, KK, BL). Funding: This work was funded through a PatientCentered Outcomes Research Institute (PCORI) Award (PCS-1409-24372). The views, statements, and opinions presented are solely the responsibility of the authors and do not necessarily represent the views of PCORI or its Board of Governors or Methodology Committee. Corresponding author: Levi N. Bonnell, MPH, 89 Beaumont Ave S459, Burlington, VT 05405 (E-mail: levi. bonnell@med.uvm.edu).
Legal Origin and the Unequal Treatment of Scientific Articles

We analyze whether editors of top-tier journals bias acceptance decisions due to cultural values that are unrelated to academic merits. Specifically, while editors raised in common law countries tend to base their acceptance decision solely on scientific merits, editors raised in civil law countries may also consider issues of solidarity, which refers to support between various groups and individuals in their country. Our results show the fraction of accepted articles by authors affiliated with a civil law country increases by a third when an editor from that same country serves at the journal. This phenomenon prevails also across civil law countries that are under the EU. Moreover, articles by EU authors that are accepted when an EU editor serves at the journal have a 10% lower impact compared to similar articles. The findings are consistent with the idea that cultural values foster agency behavior and hinder the progress of science.
Computer Networks Optimization using Load Balancing Algorithms on the Citrix ADC Virtual Server

Received December 06, 2020 Revised February 09, 2021 Accepted February 18, 2021 Published June 17, 2021 In the digital era and the outbreak of the COVID-19 pandemic, all activities are online. If the number of users accessing the server exceeds IT infrastructure, server down occurs. A load balancer device is required to share the traffic request load. This study compares four algorithms on Citrix ADC VPX load balancer: round-robin, least connection, least response time and least packet using GNS3. The results of testing response time and throughput parameters show that the least connection algorithm is superior. There were a 33% reduction in response time and a 53% increase in throughput. In the service hits parameter, the round-robin algorithm has the evenest traffic distribution. While least packet superior in CPU utilization with 76% reduction. So algorithm with the best response time and throughput is the least connection. The algorithm with the best service hits is roundrobin. Large scale implementation is recommended using the least connection algorithm regarding response time and throughput. When emphasizing evenest distribution, use a round-robin algorithm.
Alternative Investments in the Fintech Era: The Risk and Return of Non-fungible Token (NFT)

We utilize one of the earliest and largest NFT collections to investigate the pricing and the risk-return profile of NFTs. In general, we find that NFTs have higher returns than traditional financial assets. Yet, investing in NFTs comes along with extremely high volatility. The average monthly returns on NFTs range from 6.10% to 44.11%. But their standard deviations fluctuate between 44.35% and 74.57%, leading to a Sharpe ratio comparable to the NASDAQ index. NFT prices surge when there is a drastic increase in demand for alternative investments and a search for yield, especially in a low interest rate environment. We also find that the pricing of NFT largely depends on a token’s scarceness and an investor’s aesthetic preference. Hence, conventional asset-pricing models are unlikely to explain NFT returns. Overall, we provide the first comprehensive analysis that NFTs serve as a novel investment vessel in this Fintech era.
Ammonia detection using hollow waveguide enhanced laser absorption spectroscopy based on a 9.56 μm quantum cascade laser

Ammonia (NH3) is the most abundant alkalescency trace gas in the atmosphere having a foul odor, which is produced by both natural and anthropogenic sources. Chinese Emission Standard for Odor Pollutants has listed NH3 as one of the eight malodorous pollutants since 1993, specifying the emission concentration less than 1 mg/m3 (1.44ppmv). NH3 detection continuously from ppb to ppm levels is significant for protection of environmental atmosphere and safety of industrial and agricultural production. Tunable laser absorption spectroscopy (TLAS) is an increasingly important optical method for trace gas detection. TLAS do not require pretreatment and accumulation of the concentration of the analyzed sample, unlike, for example, more conventional methods such as mass spectrometry or gas chromatography. In addition, TLAS can provide high precision remote sensing capabilities, high sensitivities and fast response. Hollow waveguide (HWG) has recently emerged as a novel concept serving as an efficient optical waveguide and as a highly miniaturized gas cell. Among the main advantages of HWG gas cell compared with conventional multi-pass gas cells is the considerably decreased sample which facilitates gas exchanging. An ammonia sensor based on TLAS using a 5m HWG as the gas cell is report here. A 9. 56μm, continuous-wave, distributed feed-back (DFB), room temperature quantum cascade laser (QCL), is employed as the optical source. The interference-free NH3 absorption line located at 1046.4cm-1 (λ~9556.6nm) is selected for detection by analyzing absorption spectrum from 1045-1047 cm-1 within the ν2 fundamental absorption band of ammonia. Direct absorption spectroscopy (DAS) technique is utilized and the measured spectral line is fitted by a simulation model by HITRAN database to obtain the NH3 concentration. The sensor performance is tested with standard gas and the result shows a 1σ minimum detectable concentration of ammonia is about 200 ppb with 1 sec time resolution. Benefitting from the use of QCL and HWG, the sensor is simple and compact. Moreover, the concentration inversion algorithm is simple and suitable for embedding into the microprocessor to form a more compact and miniaturized system. The absolute measurement based on DAS without calibration can reduce the influence of light variation on measurement which may attribute to the instability of electrocircuit, optical path and laser source. Therefore, the sensor based on HWG gas cell is very well suited for sensitive and real-time monitoring ammonia in the atmosphere. Furthermore, this sensor provides the capabilities for improved the in-situ gas-phase NH3 sensing relevant for emission source characterization and exhaled breath measurements.
Examining the South African Economic and Social Renaissance

The following paper has a look at the historical context of South Africa while attempting to identify key economic drivers. To do this a Random Forest was fit to the data in order to leverage the power of machine learning and determine the feature importance. It was found that Investment GFCF is a key driver and it was confirmed by applying a linear regression in the traditional fashion.
Adherence to the Mediterranean diet and risk of functional constipation in children in Turkey: case–control study

Background: Functional constipation is often seen in children, affecting quality of life and imposing a considerable burden on health care services. The Mediterranean diet is associated with a lower risk of functional gastrointestinal disorders. Aims: This study aimed to evaluate the relationship between functional constipation and adherence to the Mediterranean diet in Turkish children aged 6–18 years. Methods: In this case–control study, 221 children with functional constipation (cases) were selected from a paediatric gastroenterology clinic between May 2018 and September 2019, and 230 children without constipation (controls) were randomly selected from those attending a well-child check-up. Cases and controls were matched on sex, age and socioeconomic characteristics. Compliance with the Mediterranean diet was assessed using the KIDMED index score. Multivariable logistic regression analysis was used to analyses the data. Results: KIDMED index scores in cases and controls were 4.0 (SD = 2.5) and 6.3 (SD = 2.4), respectively (P < 0.001). Odds ratios for functional constipation were 0.23 (95% confidence interval (CI): 0.13–0.38) for KIDMED index score 4–7 and 0.05 (95% CI: 0.03–0.11) for score ≥ 8 compared with the lowest category (score ≤ 3; P < 0.001). A negative correlation was observed between age and adherence to the Mediterranean diet. Conclusion: Good adherence to the Mediterranean diet was associated with a lower risk of functional constipation, and adherence to the Mediterranean diet decreased with age. Education on nutrition and health is warranted to help maintain and improve the health of young people in Turkey.
Development in Mechanical and Fatigue Properties of AA6061/AL2O3 Nanocomposites Under Stirring Temperature (ST)

Aluminum is expected to remain the core material for many critical applications such as aircraft and automobiles. This is due to the high resistance to different environmental conditions, desired and manageable mechanical properties, as well as high fatigue resistance. Aluminum nanocomposites such as AA6061/Al2O3 can be made in many ways using a liquid metallurgy method. The main challenges for this method in the production of nanocomposites are the difficulties of achieving a uniform distribution of reinforcing materials and possible chemical reactions between the reinforcing material and the matrix. For structural applications exclusive to aerospace sectors. The growing cost-effective nanocomposites mass production technology with essential operational and geometric flexibility is a big challenge all the time. Each method of preparing AA6061/Al2O3 nanocomposites can provide different mechanical properties. In the present study, nine nanocomposites were prepared at three stirring temperatures (800, 850, and 900 °C) with the level of Al2O3 addition of 0, 5, 7, and 9 wt %. The results of tensile, hardness and fatigue tests revealed that the composite including 9 wt % Al2O3 with 850 °C stirring temperatures has the best properties. It was also revealed that the 850 °C stirring temperature (ST) with 9 wt % Al2O3 composite provide an increase in tensile strength, VHN and reduction in ductility by 20 %, 16 % and 36.8 % respectively, compared to zero-nano. Also, the fatigue life at the 90 MPa stress level increased by 17.4 % in comparison with 9 wt % nanocomposite at 800 °C (ST). Uniform distributions were observed for all nine microstructure compositions.
Barriers and Challenges of Implementing Telerehabilitation: A Systematic Review

Objectives: Telerehabilitation (TR) is an alternative approach for providing rehabilitation services in some situations, like Coronavirus Disease 2019 (COVID-19) pandemic. There exist some obstacles, especially during the pre-implementation phase of TR, necessitating an investigation of existing local evidence. This research aimed to investigate the challenges of TR. Methods: Five electronic databases (Scopus, PubMed, Google Scholar, SID, & Magiran) were searched for studies published in English and Persian language from 2011 to February 2021. Search results in all databases provided a total of 598 articles. After reviewing the titles of the articles, we excluded 574 articles as they were duplicated and/or irrelevant. Finally, based on the inclusion and exclusion criteria, 11 articles have remained. Results: Most extracted articles were published in 2020 (n=4). The remaining articles disturbed between 2013 until 2021. These articles were mostly reviews, case reports/series, or qualitative studies and surveys. Geographically, 27% of the final selected papers belonged to the USA, 46% to Asia, and 27% to Europe. Outcomes in studies mostly included TR advantages and disadvantages, facilitators, challenges, and barriers. Discussion: Studies specified numerous challenges for TR implementation. The main challenges in the technologies used in TR were the awareness and culture of individuals and the TR infrastructure. Despite these barriers, TR could be a better treatment selection in some patients. Therefore, it is necessary for health policymakers, and especially rehabilitation managers, technology developers, scientists, and clinicians to cooperatively make serious efforts to remove these barriers.
Synergistic effect of Ocimum Sanctum and Andrographis Paniculata against Diabetic Complications

The present study explored the effect of Ocimum sanctum, Andrographis paniculata and their combination for the management of experimental diabetic vascular complications. Diabetes associated dyslipidemia and free radical generation have been connected to the pathogenesis of diabetes-induced vascular complications. Ocimum sanctum, Andrographis paniculata, possess hypolipidemic and antioxidant property, thus we evaluated their vaso-protective potential. Hydroalcoholic extract of Ocimum sanctum (200 mg/kg p.o) and hydroalcoholic extract of Andrographis paniculata (400 mg/kg p.o) were noted to possess vascular protective potential in experimental chronic diabetes. Experimental diabetes mellitus was induced by Streptozotocin (55 mg/kg i.p., once) to Wistar rats. The induction of diabetes and its associated vascular complications were assessed biochemically. Diabetes-associated dyslipidemia and tissue oxidative stress were Original Research Article Gupta et al.; JPRI, 33(33A): 151-163, 2021; Article no.JPRI. 69858 152 also assessed. Treatment of combination of Ocimum sanctum + Andrographis paniculata (300mg/kg p.o) was noted to be more efficient against the diabetes-induced vascular endothelial dysfunction and renal impairment as compared to either treatment with Ocimum sanctum (400mg/kg p.o) or Andrographis paniculata (200mg/kg p.o) or Lisinopril (1 mg/kg/day p.o.) (a reference agent). To conclude, diabetes associate oxidative stress and dyslipidemia are majorly accountable for the induction of vascular and renal impairment. The combination of Ocimum sanctum + Andrographis paniculata (300mg/kg p.o) shown the synergistic effect and may have prevented the progression of diabetes-induced vascular endothelial dysfunction and nephropathy by preventing the alteration lipid profile, restoring the serum nitrate/nitrite concentration, and decreasing the renal oxidative stress.
Calculation of mental load from e-learning student with NASA TLX and SOFI method

The learning process between students and lecturers usually occurs face-to-face in class. Technological developments and a continuous pandemic change the learning process to be a face-to-face e-learning process. The mental load during face-to-face learning is very different from learning in e-learning. This study was built using ergonomic thinking that is integrated with the use of e-learning. Cognitive ergonomics see from the point of view of students' comfort in cognitive thinking processes when doing e-learning. Data processing and testing will use a questionnaire derived from the NASA-TLX method. The results obtained from this study are the mental load calculations of each NASA TLX calculation. NASA TLX calculations show that efforts with a value of 267.29 dominate students. It could indicate that in e-learning lectures, students need more effort in conducting lectures. In addition, students experience fatigue while participating in online learning. It can be seen from the average SOFI measurement, which is only 1.26.
EVALUATION OF 3D UAS FLIGHT PATH PLANNING ALGORITHMS

Abstract. The application of image-based methods in inspections and monitoring has increased significantly over recent years. This is especially the case for the inspection of large structures that are not easily accessible for human inspectors. Here, unmanned aircraft systems (UAS) can support by generating high-quality images, that contain valuable information about the structure’s condition. To guarantee high quality and completeness for the acquired data, inspection missions are planned in advance by computing a flight path for the UAS, that covers the entire structure with the required quality. Many approaches on this topic exist that aim to solve this planning task. Nevertheless, each publication on this matter mostly stands on its own, working with its own criteria and no comparison to other approaches. Therefore, it is currently not possible to compare different approaches and select the most suitable for a specific scenario. To solve this problem, this work proposes an evaluation pipeline that applies well defined quality criteria on flight paths for close-range image-based inspections. These criteria are limited to fundamental aspects for the evaluation of paths that were created for diverse scenarios with diverse criteria and still find common ground for comparison. As experiments show, this pipeline allows the comparison of different approaches, objectifying the performance and working towards a common understanding of the current state of the art. Finally, the Bauhaus Path Planning Challenge is presented, inviting submissions to a comparison based on this pipeline to collaborate on an objective ranking, available under https://uni-weimar.de/pathplanning.