Miracle-dz/UniFAR-FTUs huggingface dataset:
Hepatotoxicity Associated with Carvedilol

Objective: The serum transaminases document is severe elevated in a patient who was receiving Carvedilol. Case Summary: A 65-year-old Saudi man admitted to hospital with acute heart failure (EF 15%), acute liver failure and acute kidney injury. He was admitted to CCU and started treatment. Within one week the kidney and the liver function improved. After that the doctor changed Bisoprolol to Carvedilol for one day only, the laboratory tests showed elevated serum transaminases. So, discontinued Carvedilol immediately and restart bisoprolol the liver function returned to the normal within four weeks. Conclusion: Carvedilol may cause liver enzymes elevated in liver impairment patient. This reaction resolves if the patient is switched to another beta- blocker. Carvedilol is contraindication in sever hepatic impairment.
Interpreting Analytical Chemistry Data: Recent Advances in Curve Resolution with the Aid of Chemometrics

This overview summarizes the application and impact of chemometrics on the extraction and interpretation of analytical data with the use of curve resolution methods from about 2005 onward. The development and usage of well-known and novel chemometric methods have been described and approximately 85 papers have been referenced. Many suggested improvements to some well-known methods, for example, multivariate curve resolution, have been noted as well as the growing software for such methods. Also, these high dimensional resolution methods have found significant application and, arguably, have opened up a new perspective in calibration, that is, extraction of otherwise unobtainable analytical information from strongly overlapping profiles in the presence of interferences. Recent literature suggests that the use of chemometric methods in analytical chemistry for data extraction and interpretation provides indispensable tools for multivariate data processing and extraction of hidden information, which otherwise would be difficult to obtain.
3-D silicon probe array with hybrid polymer interconnect for chronic cortical recording

The desire to perform chronic recordings from many channels in cortex is high among both neuroscientists and neural prosthesis researchers. The Michigan probe with integrated silicon ribbon cable has been used successfully for obtaining chronic cortical recordings in rodents. As these silicon devices are applied in larger animals and potentially in humans, however, a more mechanically robust, scalable system is required. Here we present a device that takes advantage of several existing, well-characterized technologies and methods and combines them to form a hybrid cortical assembly. The components of the assembly include thin-film multichannel silicon probes and polyimide cables that are electrically and mechanically coupled using thermocompression ball bonding. The resulting probe/cable assembly is low profile (<500 microns) and can be combined with other assemblies to form a 3-D array. Sixteen channel 2-D arrays have been implanted into rat motor cortex and have recorded chronic unit activity.
Interstitial Chemotherapy for Malignant Gliomas

Glioma is the most common primary tumor in the central nervous system (CNS). Even with aggressive treatments, gliomas remain as one of the most devastating tumors. Chemotherapy through oral administration of temozolomide (TMZ) is currently the standard regimen for malignant gliomas. However, the systemic toxicity and drug resistance are frequently observed in glioma patients. In order to improve the efficacy and minimize side effects, multiple strategies have been developed. Interstitial chemo‐ therapy is a promising one. By directly delivering chemotherapeutic agents in tumor bed, interstitial chemotherapy bypasses the blood–brain barrier (BBB) and therefore achieves a higher concentration with less systemic exposure. In this chapter, we will have a thorough review on the development and the application of interstitial chemotherapy in gliomas, with the focus on the biomaterial‐based and convection‐enhanced delivery system. In addition, the future of interstitial chemotherapy is also be shortly discussed.
Image Fusion Techniques-A Survey

: Image fusion is a process of combining two or more images captured from the same scene to produce a single image which contains the high-quality information from the source images. A single image does not contain all the objects that are correctly focused. The purpose of image fusion is to identify the focused regions from the source images and combine them to form a fused image. The fused image contains more detailed information about the source images which is very much useful for human visual perception, feature extraction and other segmentation tasks. The fused image will be more accurate and contains complete information than any of the source images. This paper presents a survey on different image fusion techniques
Using Motivational Interviewing and Constructivism to Address Information Illiteracy

Teaching complex social topics in undergraduate classrooms has become more contentious since the 2016 presidential election and the rise of information illiteracy and fake news. Information literacy, a learner’s ability to determine when they need information and how to locate and critique information based on its source and purpose, is a key component of scholarly development (Association of College and Research Libraries Board, 2015). Ironically, as access to information increases, misconceptions about current events and public policy also increase (Klurfeld & Schneider, 2014). Students are increasingly suspicious of even well-reputed fact-checking organizations meant to buffer against fake news (e.g., Snopes, PolitiFact) when the organizations report findings with which students disagree (Journell, 2017). Access to distorted and incorrect information about sociopsychological issues (e.g., gender identity, institutional racism), alongside poor information literacy, poses a significant problem for psychology educators whose learning objectives often center on multicultural competence; accurate reading and interpretation of news about psychological studies; and critical thinking about mental health, community intervention, and prevention policies. Venner and Verney (2015) proposed motivational interviewing (MI), an approach to behavior change designed to address health patient behaviors (e.g., substance use cessation; Miller & Rollnick, 1991), as a method for teaching multicultural concepts to graduate psychology students. MI posits that an individual changes when they identify reasons for change. The individual becomes more resistant to feedback when an authority (e.g., therapist, educator) tells an individual their behavior is wrong. The individual will further entrench in their current beliefs, regardless of whether these beliefs align with facts. MI, constructivism, and information literacy paradigms all assume that learning (i.e., attitude, cognitive, or behavioral change) involves an active learner who constructs their own understanding regarding a particular topic. I propose an integration of MI and constructivist learning theory to facilitate learners’ critical consumption and application of psychological concepts, that is, information literacy. This integration will assist learners and educators with course objectives often regarded as controversial, unappealing, and/or difficult to teach.
The Analyzing Technique of Program Based on Program Slicing

Program analysis plays an important role in software development and maintenance. With this method, characteristics of every variable in program can be analyzed. During the period of program analyzing, computing the program slicing by the method of constructing system dependence graph is an efficient way but the work of constructing the system dependence graph is very complicated which often leads to many wrong results. So the algorithm of hierarchy slice is used in this paper. Using the precise results, the whole program can be analyzed and the dependence relation in the program can be discovered quickly.
A Parameter Identification Method for a Battery Equivalent Circuit Model

Good battery modeling is critical for energy management of electric vehicles and hybrid electric vehicles. Because of its simplicity and satisfactory performance, equivalent circuit models are widely used in this area. A frequently adopted equivalent circuit model is one that consists of an open-circuit voltage and a resistor in series with two sets of parallel resistorcapacitor combinations. This model performs well in describing battery transient behavior due to the dynamics of such physical phenomena as mass transport effects and double layer effects. Generic methods for obtaining the parameters of this model involve analyzing the battery voltage behavior under step changes of load current. The fact that the model has two time constants places a challenge on parameter identification. Some most often used method makes use of the property that each of the two time constants plays a dominant role at different stages of the battery voltage response, and calculates the model parameters accordingly. For such method, the results are greatly influenced by the partition of faster and slower dynamics of the battery, and selection of the data points used for the calculation. Moreover, because majority of the testing data is not used towards calculating the parameters, the obtained model might not reflect the overall battery characteristics well and consequently might not give highfidelity predictions. For other methods that use nonlinear curve fitting or genetic algorithm for parameter searching, the successful implementation greatly depends on the proper setting of initial values and searching space. A novel method of parameter identification for the equivalent circuit model is presented in this paper. It makes use of a regression equation which is linear in variables that can be measured or calculated from the test. With this approach, all testing data during the relaxation period of a constant current pulse discharge or charge test is used towards obtaining the model parameters and the calculation is in the sense of least squared error. Application of the method to real battery testing data is presented. The example indicates that the method gives very good results with modeling error of less than 0.5%.
How Does Carbon Footprint Create Shared Values in the Wine Industry? Empirical Evidence from Prosecco Superiore PDO’s Wine District

Nowadays, the wine sector’s entrepreneurs are increasingly aware of the relevance of sustainability representing a crucial point for society, economy and the environment. This paper aims to describe Conegliano Valdobbiadene Prosecco DOCG (Controlled and Guaranteed Denomination of Origin) firms’ behaviour focusing on how strategic incorporation of environmentally sustainable practices and social actions contribute to strengthen their competitiveness and deliver shared value for the community. Using partial least squares structural equation modelling (PLS-SEM), survey data from 128 sparkling wine firms are analysed. The results highlight the roles of carbon footprint and employment as drivers in the creation of shared values (SVs), considering the major export markets of Prosecco Superiore DOCG. This empirical evidence may be of interest to firms in the wine sector when considering, in their business decisions, the added commercial value that is derived for the adoption of environmental practices and sustainable social actions. Hence, following this logic, they can manage more inclusive and virtuous paths towards positive social entrepreneurship and an environmental externality to the community.
Comprehensive Information Based Methodology for Natural Language Understanding

The "Comprehensive Information Based Methodology for Natural Language Understanding" presented in the paper is an application of the Comprehensive Information(CI) Theory, which was established by the author of the paper years ago for meeting the needs in artificial intelligence research. Different from other works in the field of natural language processing, the major features of the methodology presented in the paper include two folds. Firstly, instead of the syntactic or/and semantic information is used, all components of the comprehensive information are fully utilized for natural language understanding. Secondly, instead of using one or another approach preferably, both the rule-based approach and the statistics-based approach have been complementarily integrated. The successes of the research projects guided by the methodology and completed last few years prove the methodology promising.
Family Caregivers of Persons with Frontotemporal Dementia: Factors Associated with Caregiver Mental and Physical Health

Author(s): Wong, Cindy Crystal | Advisor(s): Wallhagen, Margaret I | Abstract: Individuals with the behavioral variant of frontotemporal dementia (bvFTD) commonly manifest a wide range of different behavioral problems and neuropsychiatric symptoms (Snowden et al., 2001). Therefore, providing informal support to someone with bvFTD could be particularly stressful. It is important to acknowledge the well-being and contributions of bvFTD family caregiver. Currently, however, there is a paucity of research on the unique experiences of FTD family caregivers. The purpose of this dissertation is to identify factors associated with the mental and physical health of FTD family caregivers. This dissertation will be presented as three publishable papers which are based on findings from a cross-sectional, correlational study on family caregivers of persons with FTD (with behavioral problems). Participants completed a set of questionnaires, which were submitted anonymously by standard mail. Data on 61 family caregivers were collected and analyzed.The first paper focuses on the relationship between coping and caregiver health. This paper examines the coping strategies used by caregivers in response to patient neuropsychiatric symptoms and/or behavioral problems. Emotion-focused coping was positively associated with caregiver mental health, and problem-focused coping was positively associated with caregiver physical health. The second paper focuses on the relationship between perceived control and caregiver health. There was not a statistically significantly correlation between perceived control and caregiver physical health. However, there was a strong, positive association between perceived control and caregiver mental health, suggesting that caregivers with greater perceived control tend to report better mental health. The third paper focuses on the relationship between the severity of patient symptoms and/or behavioral problems and caregiver health. There was not a statistically significant relationship between caregiver physical health and patient symptoms. However, patient symptom severity was negatively associated with caregiver mental health. Caregiver emotional distress from patient symptoms/behavioral problems was negatively associated with caregiver mental health. These findings reinforce the importance of examining the self-perceptions and unique needs of FTD family caregivers. The critical role of dementia family caregivers and the demands that they experience cannot be overlooked. Future qualitative studies on FTD family caregivers would be invaluable in providing a more in-depth understanding of their caregiving experiences. ReferenceSnowden, J. S. , Bathgate, D. , Varma, A. , Blackshaw, A. , Gibbons, Z. C. , a Neary, D. (2001). Distinct behavioral profiles in frontotemporal dementia and semantic dementia. Journal of Neurology, Neurosurgery, a Psychiatry, 70, 323-32.
Unstable intertrochanteric fracture in elderly treated with bipolar hemiarthroplasty: A prospective case series

Purpose: To evaluate functional results of bipolar hemiarthroplasty for unstable intertrochanteric fracture in elderly patient. Materials and Methods: Between 2005 and 2012 20 elderly patients more than 65 years with intertrochanteric fractures <3 weeks old, having associated medical comorbidities like diabetes mellitus, hypertension, chronic bronchitis and emphysema were included. And patients with open intertrochanteric fractures, poly-trauma, pathological fractures, and aged <65 years were excluded from study. Results: There were 11 male and 9 female patients with mean age of 78.1 years treated by cemented bipolar hemiarthroplasty. The average surgery time was 123 min with an average intraoperative blood loss of 431.5 ml. Eleven patients were transfused a pint of blood. Grade 1 bedsores in two patients healed with regular dressing, regular change of position and antibiotics. One patient developed deep wound infection for whom implant removal and excision arthroplasty was done. Limb length discrepancy was <1 cm in six patients. No case of dislocation, rotational deformities or subsidence of the prosthesis was seen during the follow-up. Functional results were graded as per Harris Hip Scoring System, mean Harris Hip Scorewas 78.2 at 6 months and 83.25 at 24 months. Conclusion: Careful restoration of neck length, offset and version maximizes the stability of the hip joint and increases the durability of the prosthesis which is very essential in achieving a good outcome. The procedure offered faster mobilization, rapid return to pre injury level and gave a lasting solution in elderly patients with intertrochanteric fractures of the femur. Level of Study: Level 4 case series.
Customer Incentive Rebalancing Plan in Free-Float Bike-Sharing System with Limited Information

Free-float bike-sharing (FFBS) systems have increased in popularity as a sustainable travel mode in recent years, especially in the urban areas of China. Despite the convenience such systems offer to customers, it is not easy to maintain an effective balance in the distribution of bikes. This study considers the dynamic rebalancing problem for FFBS systems, whereby user-based tactics are employed by incentivizing users to perform repositioning activities. Motivated by the fact that the problem is frequently faced by FFBS system operators entering a new market with limited information on travel demand, we adopt the ranking and selection approach to select the optimal incentive plan. We describe the system dynamics in detail, and formulate a profit maximization problem with a constraint on customer service level. Through numerical studies, we first establish that our procedure can select the optimal incentive plan in a wide range of scenarios. Second, under our incentive plan, the profit and service level can be improved significantly compared with the scenario without incentive provision. Third, in most cases, our procedure can achieve the optimal solution with a reasonable sample size.
Measuring and modeling per‐element angular visibility in multi‐view displays

Abstract— Multi‐view displays employ an optical layer which distributes the light of an underlying TFT‐LCD panel in different directions. Certain properties of the layer create specific artifacts, such as ghost images, moiré patterns, and masking. The layer was modeled as an image‐processing channel, and the display parameters related with the model were identified, which are importantfor the design of image‐processing algorithms for artifact mitigation. The identified parameters are interleaving pattern, angular visibility, and frequency throughput of the display. A methodology for deriving these parameters for an arbitrary LCD‐based multi‐view display are presented, which does not require precisely positioned measurement equipment. As a case study, measurement and modeling results for a particular multi‐view display are also presented.
Good reporting practices and the CONSORT Boas práticas de redação e o CONSORT

It was developed to assist authors in writing reports of randomised controlled trials, editors and peer reviewers in reviewing manuscripts for publication, and readers in critically appraising published articles. It provides guidance for reporting all randomised controlled trials, but focuses on the most common design type­individually randomised, two group, parallel trials, which accounts for over half of trials in the literature.The evidence based approach that has been used for CONSORT also served as a model for development of other reporting guidelines, such as for reporting systematic reviews and meta­analyses of studies evaluating interventions [PRISMA]
Generalized Algebraic Kernels and Multipole Expansions for Massively Parallel Vortex Particle Methods

Regularized vortex particle methods offer an appealing alternative to common mesh-based numerical methods for simulating vortex-driven fluid flows. While inherently mesh-free and adaptive, a stable implementation using particles for discretizing the vorticity field must provide a scheme for treating the overlap condition, which is required for convergent regularized vortex particle methods. Moreover, the use of particles leads to an N-body problem. By the means of fast, multipole-based summation techniques, the unfavorable yet intrinsic O(N 2 )-complexity of these problems can be reduced to at least O(N logN). However, this approach requires a thorough and challenging analysis of the underlying regularized smoothing kernels. We introduce a novel class of algebraic kernels, analyze its properties and formulate a decomposition theorem, which radically simplifies the theory of multipole expansions for this case. This decomposition is of great help for the convergence analysis of the multipole series and an in-depth error estimation of the remainder. We use these results to implement a massively parallel Barnes-Hut tree code with O(N logN)-complexity, which can perform complex simulations with up to 10 8 particles routinely. A thorough investigation shows excellent scalability up to 8192 cores on the IBM Blue Gene/P system JUGENE at Julich Supercomputing Centre. We demonstrate the code’s capabilities along different numerical examples, including the dynamics of two merging vortex rings. In addition, we extend the tree code to account for the overlap condition using the concept of remeshing, thus providing a promising and mathematically well-grounded alternative to standard mesh-based algorithms.
The Effect of Value Congruence Between Founder and Successor on Successor’s Willingness: The Mediating Role of the Founder–Successor Relationship

Drawing from social exchange theory, this article explores the founder–successor relationship quality as a mediated pathway in examining the effects of founder–successor value congruence on successor’s willingness to take over the business. Based on survey data from 102 founder–successor dyads, polynomial regression analysis shows that when both a founder and a successor have high value congruence in family prosperity, the relationship quality will be enhanced, which leads to higher successor’s willingness. When there is value incongruence between a founder and a successor, the successor’s family prosperity value has a more important impact on the founder–successor relationship and successor’s willingness.
Öğretmenlik Uygulamasında İşbirliği Bir Durum Çalışması

The aim of this study was to elicit whether administrators in educational faculty, principals of schools, tutors, mentors and student teachers have enough information about collaboration on which topic and how they could make it. In this study case study design which is one of the qualitative research methods was adopted. Data was collected administering a questionnaire contained open-ended questions. Descriptive analyses technique was administered on the collected data. The results of the study indicated that administrators in educational faculty and tutors have enough information about collaboration on which topic and how they could make it, while the others have not.