Miracle-dz/UniFAR-FTUs huggingface dataset:
Stable Renal Function After Islet Transplantation: Importance of Patient Selection and Aggressive Clinical Management

Background. Proteinuria development and decrease in glomerular filtration rate (GFR) have been observed after successful islet transplantation. The aim of this study was to determine clinical, laboratory, and immunosuppressant-related factors associated with kidney dysfunction in islet transplant recipients. Methods. A retrospective cohort study was conducted in 35 subjects submitted to pancreatic islet transplantation for treatment of unstable type 1 diabetes mellitus. Demographic, anthropometrical, and laboratory data, as well as immunosuppressive and antihypertensive therapy were recorded. Kidney function was assessed by albuminuria and estimated GFR (eGFR), calculated by modification of diet in renal disease formula. Results. Age was the only independent risk factor for low eGFR (<60 mL/min/1.73 m2) (odds ratio [OR]=1.78 [1.22–2.61]). Low-density lipoprotein cholesterol (OR=2.90 [1.37–6.12]) and previous microalbuminuria (OR=6.42 [1.42–29.11]) were risk factors for transient macroalbuminuria. Interestingly, tacrolimus was a protective factor for macroalbuminuria (OR=0.12 [0.06–0.26]). Six of 30 (20%) normoalbuminuric subjects at baseline progressed to microalbuminuria. No subject developed sustained macroalbuminuria. Surprisingly, overall eGFR remained stable during follow-up (before transplant: 74.0±2.0; during immunosuppressive therapy: 75.4±2.8; and after withdrawal: 76.3±5.3 mL/min/1.73 m2; P>0.05). Even subjects with low eGFR and microalbuminuria at baseline (n=10) maintained stable values posttransplantation (61.13±3.25 mL/min/1.73 m2 vs. 63.32±4.36 mL/min/1.73 m2, P=0.500). Conclusions. Kidney function remained stable after islet transplantation alone. The unchanged kidney function found in this sample may be attributed to healthier kidney status at baseline and possibly to prompt treatment of modifiable risk factors. Aggressive treatment of risk factors for nephropathy, such as blood pressure, low-density lipoprotein cholesterol, and careful tacrolimus levels monitorization, should be part of islet transplant recipient care.
The Probabilistic Collocation Method for dealing with uncertainties in power system small disturbance studies

This paper applies the Probabilistic Collocation Method (PCM) to modeling operational uncertainties in small disturbance power system studies. The PCM is a method of estimating the statistical distribution of a system output from the uncertain parameter values using significantly fewer full system simulations than traditional sampling techniques. The application of PCM is illustrated on a small, two area transmission system. Probabilistic locations for all system electromechanical modes in the presence of system uncertainties have been estimated accurately. Furthermore, the method provides vast time savings and could facilitate a move towards online probabilistic power system studies.
Evaluation of a new system for chest tomosynthesis: aspects of image quality of different protocols determined using an anthropomorphic phantom

Objective: To compare the image quality obtained with the different protocols in a new chest digital tomosynthesis (DTS) system. Methods: A chest phantom was imaged with chest X-ray equipment with DTS. 10 protocols were used, and for each protocol, nine acquisitions were performed. Four observers visually rated the quality of the reconstructed section images according to pre-defined quality criteria in four different classes. The data were analysed with visual grading characteristics (VGC) analysis, using the vendor-recommended protocol [12-s acquisition time, source-to-image distance (SID) 180cm] as reference, and the area under the VGC curve (AUC VGC ) was determined for each protocol and class of criteria. Results: Protocols with a smaller swing angle resulted in a lower image quality for the classes of criteria “ disturbance ” and “ homogeneity in nodule ” but a higher image quality for the class “ structure ” . The class “ demarcation ” showed little dependency on the swing angle. All protocols but one (6.3 s, SID 130 cm) obtained an AUC VGC significantly , 0.5 (indicating lower quality than reference) for at least one class of criteria. Conclusion: The study indicates that the DTS protocol with 6.3s yields image quality similar to that obtained with the vendor-recommended protocol (12s) but with the clinically important advantage for patients with respiratory impairment of a shorter acquisition time. Advances in knowledge: The study demonstrates that the image quality may be strongly affected by the choice of protocol and that the vendor-recommended protocol may not be optimal.
Pyk2 is essential for astrocytes mobility following brain lesion

Proline‐rich tyrosine kinase 2 (Pyk2) is a calcium‐dependent, non‐receptor protein‐tyrosine kinase of the focal adhesion kinase (FAK) family. Pyk2 is enriched in the brain, especially the forebrain. Pyk2 is highly expressed in neurons but is also present in astrocytes, where its role is not known. We used Pyk2 knockout mice (Pyk2−/−) developed in our laboratory to investigate the function of Pyk2 in astrocytes. Morphology and basic properties of astrocytes in vivo and in culture were not altered in the absence of Pyk2. However, following stab lesions in the motor cortex, astrocytes‐mediated wound filling was slower in Pyk2−/− than in wild‐type littermates. In an in vitro wound healing model, Pyk2−/− astrocytes migrated slower than Pyk2+/+ astrocytes. The role of Pyk2 in actin dynamics was investigated by treating astrocytic cultures with the actin‐depolymerizing drug latrunculin B. Actin filaments re‐polymerization after latrunculin B treatment was delayed in Pyk2−/− astrocytes as compared with wild‐type astrocytes. We mimicked wound‐induced activation by treating astrocytes in culture with tumor‐necrosis factor alpha (TNFα), which increased Pyk2 phosphorylation at Tyr402. TNFα increased PKC activity, and Rac1 phosphorylation at Ser71 similarly in wild‐type and Pyk2‐deficient astrocytes. Conversely, we found that gelsolin, an actin‐capping protein known to interact with Pyk2 in other cell types, was less enriched at the leading edge of migrating Pyk2−/− astrocytes, suggesting that its lack of recruitment mediated in part the effects of the mutation. This work shows the critical role of Pyk2 in astrocytes migration during wound healing. GLIA 2016;64:620–634
A Hybrid PWM Strategy for Three-Level Inverter With Unbalanced DC Links

The dc links of the three-level neutral-point-clamped (3L-NPC) converter are needed to work in imbalanced state in some special fields, and a hybrid pulsewidth modulation (PWM) strategy in this case is studied in this paper. The proposed strategy is a combination of the space-vector PWM and carrier-based modulation (CBM) method. The characteristic of the revised space-vector diagram (RSVD) with unbalanced dc links is studied from a new perspective, and based on it, a novel sector distribution method is proposed to identify the utilized switching sequences. Instead of calculating the durations of the adopted space vectors in the asymmetrical and complicated RSVD, the proposed strategy adopts the CBM with well-calculated injected zero-sequence voltage (IZSV) to produce the pulses directly. The IZSV calculating methods to realize the asymmetric control of dc-link voltages for both the continuous and discontinuous PWM are studied in detail. Simulated and experimental results are given to validate the effectiveness.
Boiler Flame Image Classification Based on Hidden Markov Model

The classification is an important domain in boiler flame image processing and is a preliminary step toward detection, recognition and understanding of combustion condition. In this paper, a hidden Markov model (HMM) approach is introduced into boiler flame image classification. Firstly, we define a feature vector for each flame image including 5 feature elements, which are the brightness of flame, the area of the high temperature flame, the brightness of high temperature flame, the rate of area of the high temperature flame, the offset of the flame centroid respectively. Next, for classification and recognition of the flame image, a method of the maximum posterior marginal (MPM) based on the hidden Markov random field model, which is described as a probabilistic framework for learning probability distribution defined on the sample space, is introduced. Then, we construct a sample space including 63 flame images, parts of which are used to train the model. Finally, the entire samples are recognized and classified. Experiments prove this method is effective for classification of boiler flame images
Reading and Phonological Awareness in Reading-Disabled Adults

Sixty-eight students with reading disabilities (RDs) and 55 non-reading-disabled university undergraduates composed the sample. Students with RDs met either low achievement (LA) or regression-based discrepancy (D) criteria. In addition to IQ and reading decoding measures, all participants received measures of phonological awareness (PA), confrontation naming, and verbal fluency. Consistent with expectations, the D and LA subgroups did not differ from one another, and both performed worse than students without RD on phonological measures. However, only the LA subgroup performed worse on measures of confrontation naming and verbal fluency. Subgroups of readers who had LA without an IQ-achievement discrepancy (LA-no D) and readers who had both LA and a discrepancy (LA + D), performed worse than readers who had a discrepancy but whose reading achievement was above the 16th percentile (D-no LA) on measures of PA, naming, and fluency; this subgroup did not differ from students without RDs. These results question the utility of determining RD in adults solely on the basis of IQ-achievement discrepancy criterion without regard to other linguistic skills or absolute reading level.
Combination of Compensations and Multi-Parameter Coil for Efficiency Optimization of Inductive Power Transfer System

A loosely coupled inductive power transfer (IPT) system for industrial track applications has been researched in this paper. The IPT converter using primary Inductor-Capacitor-Inductor (LCL) network and secondary parallel-compensations is analyzed combined coil design for optimal operating efficiency. Accurate mathematical analytical model and expressions of self-inductance and mutual inductance are proposed to achieve coil parameters. Furthermore, the optimization process is performed combined with the proposed resonant compensations and coil parameters. The results are evaluated and discussed using finite element analysis (FEA). Finally, an experimental prototype is constructed to verify the proposed approach and the experimental results show that the optimization can be better applied to industrial track distributed IPT system.
High power DC/AC/DC converter based on different modulation strategies

The recent researches on high voltage and power DC/DC converter mainly focus on topology. The newest topology based on modular multilevel converter(MMC) is composed of a transformer coupling two three-phase MMC, so that it can be easily extended according to the required voltage rating. However, the present topology almost adopt the same modulation strategy at two sides of converter. Because of the different applications of the high power DC/DC converter, the voltages on two sides will be different leading to the number of submodules (SM) different. For the different structure mentioned above, this paper presents the method which takes different modulation strategies at two sides of converter. It respectively selects the optimal modulation strategy according to the SM number at two sides, which could reduce switching losses and harmonic content. Finally, a simulation model of 5kV/500V DC/AC/DC converter is established in MATLAB/Simulink, which verifies the feasibility of the method.
Synthesis of Phosphorus‐Doped Graphene and its Multifunctional Applications for Oxygen Reduction Reaction and Lithium Ion Batteries

We develop a simple and economical thermal annealing method for the synthesis of phosphorus-doped graphene, which exhibits remarkable electrocatalytic activity towards the oxygen reduction reaction and enhances the electrochemical performance as an anode material for lithium ion batteries. The experimental results suggest the significant role of phosphorus atoms in graphene.
A double-blind crossover trial of imipramine and phenelzine for outpatients with treatment-refractory depression.

OBJECTIVE Data from controlled studies concerning the response rates of patients to a second antidepressant medication after they have been unresponsive to a systematic trial of another antidepressant are extremely useful to clinicians for rational prescription of pharmacotherapy. Such information allows making an accurate prognosis, sustaining realistic hope in the patient, and achieving the best possible therapeutic outcome. This study was designed to add to the scanty literature available on this subject. METHOD Eighty-nine mood-reactive, nonmelancholic, mainly chronically depressed outpatients at a university research clinic who were unresponsive to vigorous double-blind trials of imipramine or phenelzine were crossed over to treatment with the other drug under double-blind conditions. RESULTS Of 46 patients previously unresponsive to imipramine who completed phenelzine treatment, 31 (67%) responded to phenelzine. Of 22 patients previously unresponsive to phenelzine who completed imipramine treatment, nine (41%) responded to imipramine. The difference in response rates was statistically significant. Even after they had shown no response to 7 weeks of placebo and 6 weeks of imipramine treatment, 10 (83%) of 12 patients who then completed treatment with phenelzine responded. CONCLUSIONS These data suggest that among chronically ill, mood-reactive depressed patients with many symptoms of atypical depression, phenelzine is strikingly effective in those who have been nonresponders to imipramine and should be tried in such patients.
Therapy Left Ventricular Remodeling After Myocardial Infarction : Pathophysiology and

Copyright © 2000 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online 72514 Circulation is published by the American Heart Association. 7272 Greenville Avenue, Dallas, TX 2000;101;2981-2988 Circulation Martin G. St. John Sutton and Norman Sharpe Therapy Left Ventricular Remodeling After Myocardial Infarction : Pathophysiology and http://circ.ahajournals. org/cgi/content/full/101/25/2981 located on the World Wide Web at: The online version of this article, along with updated information and services, is
Analysis of Modified Degree Six Chordal Rings and Traditional Chordal Rings Degree Six interconnection network

Chordal rings are attractive network interconnection due to their short diameters especially when the degree was increased. Chordal rings were related to find the shortest path in a ring structured. This paper presents an analysis of modified degree six chordal rings (CHRm6) and chordal rings degree six (CR6) or commonly known as traditional chordal rings degree six (CR6). This analysis includes the structures, tree visualization, paths, formulations and geometrical representation. The comparison of diameters was made between theoretical and ideal graphs for these two methods. We tested and compared for a large number of nodes. CHRm6 gives shortest diameters for even and odd source node.
Stereotype Threat Strengthens Automatic Recall and Undermines Controlled Processes in Older Adults

The threat of being judged stereotypically (stereotype threat) may impair memory performance in older adults, thereby producing inflated age differences in memory tasks. However, the underlying mechanisms of stereotype threat in older adults or other stigmatized groups remain poorly understood. Here, we offer evidence that stereotype threat consumes working memory resources in older adults. More important, using a process-dissociation procedure, we found, for the first time, that stereotype threat undermines the controlled use of memory and simultaneously intensifies automatic response tendencies. These findings indicate that competing models of stereotype threat are actually compatible and offer further reasons for researchers and practitioners to pay special attention to age-related stereotypes during standardized neuropsychological testing.
A new statistical approach for fault-tolerant VLSI systems

A novel approach to the statistics of fault-tolerant VLSI systems is presented by compounding binomial distributions with a beta distribution. This technique was discovered in the analysis of fault-tolerant dynamic random-access memory (DRAM) chips. Manufacturing data supporting this method are shown and the application of the approach to standard fault-tolerance schemes is described. Special forms of these statistics for computer calculations are also discussed and examples are given. <<ETX>>
Beyond von Neumann—logic operations in passive crossbar arrays alongside memory operations

The realization of logic operations within passive crossbar memory arrays is a promising approach to expand the fields of application of such architectures. Material implication was recently suggested as the basic function of memristive crossbar junctions, and single bipolar resistive switches (BRS) as well as complementary resistive switches (CRS) were shown to be capable of realizing this logical functionality. Based on a systematic analysis of the Boolean functions, we demonstrate here that 14 of 16 Boolean functions can be realized with a single BRS or CRS cell in at most three sequential cycles. Since the read-out step is independent of the logic operation steps, the result of the logic operation is directly stored to memory, making logic-in-memory applications feasible.
Wireless OFDM Systems: How to Make Them Work?

IP is the protocol of choice in most corporate networks today. As those networks grow larger and their operation becomes vital for the enterprise, there is a strong need to design.or redesign them in a manner that will allow for their expansion while simultaneously maintaining smooth and stable operation. CCIE Professional Development: Advanced.IP Network Design presents the principles of good IP network design and is focused on planning corporate networks from the routing point of view. Choice of transport technologies, dimensioning of the network links, choice of routers, and routing problems specific to carrier networks are outside the scope of this book, The hook is targeted at network enpineers seeking solutions to grow and stabilize their networks. A general knowledge of IP networking and routing is required for understanding the presented material. It is, however, possible to gain basic understanding of routing protocols operation from the appendices. The book consists of four parts. Part One (Chapters 1 4 ) deals with network design principles, Part Two (Chapters 5-7) deals with interior routing, and Part Three (Chapters 8 and 9) deals with exterior routing. Part Four contains appendices. A consistent example network is used throughout this book to illustrate different design choices. Also, each chapter contains case studies, which either serve as a design example or present problems that may arise in particular circumstances. Each chapter ends with a summary and review questions. Chapter 1 introduces the main network design goal, which is stability, and discusses fadtbrs that affect stability in real networks. The authors suggest a threelayer network topology, consisting of core, distribution, and access layers, and present the design goals for each layer. Chapter 2 begins with general information necessary for understanding the IP address summarization followed by a discussion of the effect of summarizing at different places in the network. The remaining part of Chapter 2 deals with addressing. Four different address allocation strategies are discussed, allowing the reader to choose the most appropri.ate strategy depending on needs. Two case studies end Chapter 2. The first one deals with the problems that arise when a default route is set to an interBOOK REVIEWS/EDITED BY ANDRZEJ JAISZCZYK U I
An Electrochemical Biosensor Based on AuNP-Modified Gold Electrodes for Selective Determination of Serum Levels of Osteocalcin

This paper reports a step-wise protocol to immobilize corresponding antibody on gold electrodes for electrochemical measurement of Osteocalcin (Oc), a bone turnover marker, levels in human serum. To our knowledge this is the first such sensor developed for Oc measurement. The magnitude of electrochemical response current was linearly dependent on Oc concentration with an R square of 0.99. The detection limit was calculated to be 0.65 ng/mL. The sensor was capable to assess antigen levels of 2.5–90 ng/mL. The correlation between our sensor results and that of electrochemiluminescence (ECLIA), the current state-of-art, was also investigated and the results showed a high correlation (slope of 0.97 and R2 of 0.98) between the two systems. This is while the total assay time for the Oc sensor is about 5 min and ECLIA needs several hours to be performed.
Microtrapping of volatile organic compounds with carbon nanotubes

Micro-sorbent traps referred to as microtraps serve as integrated concentration-injection devices for continuous monitoring in gas phase streams. The application of carbon nanotubes as unique sorbents for the fabrication of microtraps for the nano-scale adsorption/desorption of volatile organic molecules is presented in this paper. The microtrap application requires high adsorption capacity as well as easy desorbability; the latter being critical for injection mode of these integrated devices. The micro-sorbent characteristics of single and multi-walled carbon nanotubes for gas phase adsorption/desorption of several volatile organic compounds like DCM, ethanol and benzene etc. has been studied. The nonporous nature of carbon nanotubes (CNTs) eliminates the mass transfer resistance related to diffusion into pore structures, thus allowing easy desorbability. At the same time, their high aspect ratios lead to large breakthrough volumes. As compared to a commercial sorbent carbopack TM , the breakthrough volume was as much as an order of magnitude higher in the CNTs, while the higher rate of desorption measured as the peak width at half height of the desorption band was found nearly eight times lower (i.e., 0.26 seconds with SWNT and 1.89 seconds with carbopack TM ). The trapping and desorption characteristics of single and multi walled nanotubes were found to be comparable. We also found that the presence of disordered carbon impurities, which could be removed by controlled oxidative annealing, could greatly degrade the performance of CNTs. This research has suggested that CNTs can be used in micro-sorbent traps and surprisingly enhance the efficiency of the integrated concentration-injection devices. Consequently, this will open the doors to the application of high-capacity, CNTs-based sorbents as a better alternative to conventional sorbent in continuous monitoring devices.
Direct power control for voltage source inverter without phase-locked loop under harmonically distorted voltage conditions

This paper proposes a direct power control (DPC) strategy for the grid-connected voltage source inverter (VSI) without phase-locked loop (PLL) under harmonically distorted voltage conditions. A virtual angular is employed instead of the voltage vector angular acquired by the PLL. The second-order vector integrator (SOVI) is integrated with the DPC to implement two different control targets of smooth active and reactive power or sinusoidal output current. Then, the different control performances of the SOVI and the second-order generalized integrator (SOGI) are discussed and compared. Finally, simulation results validate the effectiveness of the method.