Miracle-dz/UniFAR-FTUs huggingface dataset:
Successful Integration of Hepatitis C Virus Point-of-Care Tests into the Denver Metro Health Clinic

Background. The Centers for Disease Control and Prevention (CDC) recommends testing and linkage to care for persons most likely infected with hepatitis C virus (HCV), including persons with human immunodeficiency virus. We explored facilitators and barriers to integrating HCV point-of-care (POC) testing into standard operations at an urban STD clinic. Methods. The OraQuick HCV rapid antibody test was integrated at the Denver Metro Health Clinic (DMHC). All clients with at least one risk factor were offered the POC test. Research staff conducted interviews with clients (three HCV positive and nine HCV negative). Focus groups were conducted with triage staff, providers, and linkage-to-care counselors. Results. Clients were pleased with the ease of use and rapid return of results from the HCV POC test. Integrating the test into this setting required more time but was not overly burdensome. While counseling messages were clear to staff, clients retained little knowledge of hepatitis C infection or factors related to risk. Barriers to integrating the HCV POC test into clinic operations were loss to follow-up and access to care. Conclusion. DMHC successfully integrated HCV POC testing and piloted a HCV linkage-to-care program. Providing testing opportunities at STD clinics could increase identification of persons with HCV infection.
Haemodynamic effects of carbetocin and oxytocin given as intravenous bolus on women undergoing caesarean delivery: a randomised trial

Please cite this paper as: Moertl M, Friedrich S, Kraschl J, Wadsack C, Lang U, Schlembach D. Haemodynamic effects of carbetocin and oxytocin given asintravenous bolus on women undergoing caesarean delivery: a randomised trial. BJOG 2011;118:1349–1356.
Getting guidelines into practice: a literature review.

Background Clinical guidelines have the potential to ensure that a research knowledge base underpins practice. Their development nationally and locally has increased dramatically in recent years. The challenge lies in implementing them. This literature review of guideline implementation was conducted to inform the development of implementation strategies for the Royal College of Nursing national clinical guidelines. Conclusion The evidence base for guideline implementation is still developing and many ideas and strategies require further testing. Although strategies can be developed around some core principles, as yet there is no single definitive strategy. This selective literature review offers some insight into successful implementation strategies.
Expression of caspase-3 and c-myc in non-small cell lung cancer.

PURPOSE Caspase-3 is a cysteine protease that plays an important role in the process of apoptotic cell death, but little has been studied clinically on caspase-3 in lung cancer. Increased c-myc expression can result in mitosis or apoptosis, and its contribution to the pathogenesis and prognosis of lung cancer has gained interest. In the present study, the expressions of caspase-3 and c-myc, along with their possible correlations with prognostic variables, were analyzed in resected non-small cell lung carcinomas (NSCLC). MATERIALS AND METHODS Archival tumor tissues from 147 previously untreated NSCLC patients were examined by immunohistochemistry for the expressions of caspase-3 and c-myc proteins. Clinical information was obtained through the computerized retrospective database from the tumor registry. RESULTS The expressions of caspase-3 and c-myc were detected in 60 (88/147) and 16% (24/147) of tumors, respectively. No association was found between caspase-3 and c-myc expressions. A multivariate analysis demonstrated the N status and pathologic stage to be significantly correlated with poor survival (p-value=.018 and .002, respectively), but positive expression of caspase-3 was associated with a good prognosis (p=.03). CONCLUSION Our data suggest the involvement of caspase-3 in the tumorigenesis of NSCLC. It is also noteworthy that caspase-3 expression might be a favorable prognostic indicator in these tumors.
Anterior Spinal Fusion Versus Posterior Spinal Fusion for Moderate Lumbar/Thoracolumbar Adolescent Idiopathic Scoliosis: A Prospective Study

Study Design. A prospective study. Objective. Comparison study of radiologic and clinical outcomes, efficiency, and cost between anterior spinal fusion (ASF) and posterior spine fusion (PSF) in surgical treatment of moderate lumbar/thoracolumbar adolescent idiopathic scoliosis (AIS). Summary of Background Data. ASF and PSF indicated for lumbar and thoracolumbar adolescent idiopathic scoliosis surgical treatment have respective advantages and disadvantages. However, up until today, a related prospective AIS comparative study has rarely been reported. Methods. Thirty-two cases in this prospective study with patients enrolled in either method A or B alternately in a sequence were divided into 2 groups. Group A underwent ASF with single solid rod and single screw constructs, and group B underwent PSF with segmental total pedicle screw system. Inclusion criteria were: (1) AIS diagnosis; (2) diagnosis classification as Lenke5CN type; (3) Cobb angles 35°–60°on anteroposterior view radiographs. Exclusion criteria were: (1) a history of spinal surgery; (2) age younger than 10 years; (3) Risser sign 0°; (4) lumbar/thoracolumbar kyphosis. All patients were observed with 2-year minimum follow-up (24–46 months). Clinical and radiologic outcomes of both groups A and B were analyzed. Results. Statistical t test or Mann-Whitney U test demonstrated no significant difference in preoperative age (P = 0.380), Risser sign (P = 0.733), magnitude (P = 0.936), flexibility (P = 0.815), apical vertebra rotation (AVR, P = 0.756), and apical vertebra translation (AVT, P = 0.355) of the lumbar/thoracolumbar curves, trunk shift (TS, P = 0.448), sagittal kyphosis from T5–T12 (P = 0.792) and sagittal lordosis from L1–L5 (P = 0.299). Average coronal correction of thoracolumbar/lumbar curves was 83% after surgery and 77% at follow-up in group A and 87% after surgery and 82% at follow-up in group B (P = 0.236 and P = 0.138). No significant differences were observed regarding correction of sagittal alignment, TS, AVT, AVR and hospitalization days on last follow-up between both groups (P > 0.05). No pseudarthrosis, reoperation, neurologic complications, infection, and no other problems were observed. Excellent clinical fusion results were present in all patients on their last follow-up. However, significant differences were evident in group A in regards to reduced operative time (P = 0.046), reduced estimated blood loss (P = 0.003), decreased blood transfusion (P = 0.006), reduced implants cost and hospitalization expenses (P = 0.000). Additionally, group A had shorter fusion levels than group B (p50 = 4 vs. p50 = 5, P = 0.003). Conclusion. ASF versus PSF comparison in treating moderate lumbar/thoracolumbar AIS did not show significant differences in regards to safety or efficacy but demonstrated shorter fusion levels, reduced surgical trauma and costs in ASF.
Protein O-Fucosyltransferase 1 Expression Impacts Myogenic C2C12 Cell Commitment via the Notch Signaling Pathway

ABSTRACT The Notch signaling pathway plays a crucial role in skeletal muscle regeneration in mammals by controlling the transition of satellite cells from quiescence to an activated state, their proliferation, and their commitment toward myotubes or self-renewal. O-fucosylation on Notch receptor epidermal growth factor (EGF)-like repeats is catalyzed by the protein O-fucosyltransferase 1 (Pofut1) and primarily controls Notch interaction with its ligands. To approach the role of O-fucosylation in myogenesis, we analyzed a murine myoblastic C2C12 cell line downregulated for Pofut1 expression by short hairpin RNA (shRNA) inhibition during the time course of differentiation. Knockdown of Pofut1 affected the signaling pathway activation by a reduction of the amount of cleaved Notch intracellular domain and a decrease in downstream Notch target gene expression. Depletion in Pax7+/MyoD− cells and earlier myogenic program entrance were observed, leading to an increase in myotube quantity with a small number of nuclei, reflecting fusion defects. The rescue of Pofut1 expression in knockdown cells restored Notch signaling activation and a normal course in C2C12 differentiation. Our results establish the critical role of Pofut1 on Notch pathway activation during myogenic differentiation.
Two efficient and stable MMSE detection algorithms for the V‐BLAST system

For practical consideration, efficient and stable implementation of the promising vertical Bell Labs Layered Space–Time system is highly desirable. The original square‐root algorithm (SRA), proposed by Hassibi, for the minimum mean square error detection, is composed of three stages, that is, initialization, ordering, and nulling. Unlike the original SRA whose initialization stage is not completely based on unitary transformations, the three stages of our proposed algorithm #1 are all based on unitary transformations. The average number of multiplications required by our proposed algorithm #1 is about (29∕10)M3, where both the numbers of transmit and receive antennas are equal to M. In the meantime, the average number of multiplications required by the original SRA is (17∕3)M3. In addition to the stable initialization, ordering, and nulling considered by the proposed algorithm #1, our proposed algorithm #2 considers stable detection. Our proposed algorithm #2 is completely based on Givens rotations, which is to be implemented by COordinate Rotation DIgital Computer‐based hardwares. Copyright © 2011 John Wiley & Sons, Ltd.
Observation of resolved glucose signals in 1H NMR spectra of the human brain at 4 Tesla

Measurement of the resonances of glucose between 3.2 and 3.9 ppm in 1H NMR spectra from the human brain is difficult due to spectral overlap with peaks from more concentrated metabolites. The H1 resonance of α‐D‐glucose at 5.23 ppm is resolved from other metabolite peaks, but potentially overlaps with the intense water signal at 4.72 ppm. This paper demonstrates that the increased resolution at 4 Tesla permits to suppress the water signal sufficiently to reliably detect glucose directly at 5.23 ppm by 1H MRS and the estimated peak intensity is consistent with previous 13C NMR quantification.
Dependence of resolvin-induced increases in corneal epithelial cell migration on EGF receptor transactivation.

PURPOSE To determine whether resolvin E1 (RvE1), an endogenous oxygenation product of eicosapentaenoic acid (EPA), induces increases in migration in human corneal epithelial cells (HCECs) and to identify signal pathways mediating this response. METHODS Migration was measured with the scratch wound assay. Western blot analysis identified changes in the phosphorylation status of prospective intracellular signal transduction mediators. Immunocytochemistry probed for intracellular paxillin localization and actin reorganization. RESULTS RvE1 enhanced HCEC migratory rates to levels comparable to those induced by epidermal growth factor (EGF). These increases were accompanied by increases in the phosphorylation status of epidermal growth factor receptor (EGFR), Akt, p38 MAPK, GSK-3α/β, and paxillin, which essentially persisted for up to 60 minutes. The EGFR inhibitor AG1478 blocked the subsequent effects of RvE1 to induce increases in phosphorylation status and cell migration. The PI3-K inhibitor LY294002 or wortmannin or the p38 inhibitor BIRB796 blocked resolvin-induced increases in cell migration. Either the matrix metalloproteinase (MMP) inhibitor GM6001 or the specific heparin-bound EGF-like growth factor inhibitor CRM197 suppressed RvE1-induced stimulation of EGFR/PI3-K/Akt phosphorylation and cell migration. CONCLUSIONS RvE1 enhances HCEC migration through MMP and sheddase-mediated EGFR transactivation. This response is dependent on PI3-K and p38-linked signaling eliciting paxillin (Tyr118) phosphorylation.
Input features Context + /-15 down sampled by factor 5 Second stage network

In this paper, we explore multilingual feature-level data sharing via Deep Neural Network (DNN) stacked bottleneck features. Given a set of available source languages, we apply language identification to pick the language most similar to the target language, for more efficient use of multilingual resources. Our experiments with IARPA-Babel languages show that bottleneck features trained on the most similar source language perform better than those trained on all available source languages. Further analysis suggests that only data similar to the target language is useful for multilingual training.
Running Head : BULLYING EXPERIENCES Bullying Experiences among Children and Youth with Autism Spectrum Disorders

Few studies have investigated bullying experiences among children diagnosed with autism spectrum disorders (ASD); however, preliminary research suggests that children with ASD are at greater risk for being bullied than typically developing peers. The aim of the current study was to build an understanding of bullying experiences among children with ASD based on parent reports by examining rates of various forms of bullying, exploring the association between victimization and mental health problems, and investigating individual and contextual variables as correlates of victimization. Victimization was related to child age, internalizing and externalizing mental health problems, communication difficulties, and number of friends at school, as well as parent mental health problems. Bullying prevention and intervention strategies are discussed.
Is Stroke History Reliably Reported by Elderly with Cognitive Impairment? A Community-Based Study

Background/Aims: Self-reported history of stroke has been questioned in the elderly due to the high prevalence of cognitive impairment. We tested the validity of response to a stroke questionnaire versus clinical diagnosis of stroke among elderly people with and without cognitive impairment. Methods: Community-dwelling participants to the phase 1 Canadian Study of Health and Aging were screened for self-reported stroke. Physician-diagnosed stroke was set as the gold standard. The positive predictive value (PPV), sensitivity and specificity were determined. Results: 1,536/ 1,659 (93%) participants aged 65 years and over had stroke information from both sources. Among stroke positive responders, the PPV was 81% overall: 76% for cognitively normal, 84% for cognitively impairment with no dementia (CIND), and 82% for demented. Among stroke diagnosed by physicians, history of stroke was reported by 38% cognitively normal, 54% CIND, and 55% demented. The specificity was over 97% in all cognitive categories. Conclusion: Among community-dwelling elderly people, any cognitive impairment did not imply inaccurate self-reported history of stroke. High prevalence of stroke and frequent contacts with health services among cognitively-impaired elderly may increase the awareness of stroke symptoms and signs. Stroke increases the risk of developing dementia in both cognitively normal and CIND, and efforts to accomplish stroke prevention are justified, especially in these categories.
Timing optimization of combinational logic

An algorithm for speeding up combinational logic with minimal area increase is presented. A static timing analyzer is used to identify the critical paths. Then a weighted min-cut algorithm is used to determine the subset of nodes to be resynthesized. This subset is selected so that the speedup is achieved with minimal area increase. Resynthesis is done by selectively collapsing the logic along the critical paths and then decomposing the collapsed nodes to minimize the critical delay. This process is iterated until either the timing requirements are satisfied or no further improvement can be made. The algorithm has been implemented and tested on many design examples with promising results. <<ETX>>
Prognostic value of ambulatory blood-pressure recordings in patients with treated hypertension.

BACKGROUND It is uncertain whether ambulatory blood-pressure measurements recorded for 24 hours in patients with treated hypertension predict cardiovascular events independently of blood-pressure measurements obtained in the physician's office and other cardiovascular risk factors. METHODS We assessed the association between base-line ambulatory blood pressures in treated patients and subsequent cardiovascular events among 1963 patients with a median follow-up of 5 years (range, 1 to 66 months). RESULTS We documented new cardiovascular events in 157 patients. In a Cox proportional-hazards model with adjustment for age, sex, smoking status, presence or absence of diabetes mellitus, serum cholesterol concentration, body-mass index, use or nonuse of lipid-lowering drugs, and presence or absence of a history of cardiovascular events, as well as blood pressure measured at the physician's office, higher mean values for 24-hour ambulatory systolic and diastolic blood pressure were independent risk factors for new cardiovascular events. The adjusted relative risk of cardiovascular events associated with a 1-SD increment in blood pressure was 1.34 (95 percent confidence interval, 1.11 to 1.62) for 24-hour ambulatory systolic blood pressure, 1.30 (95 percent confidence interval, 1.08 to 1.58) for ambulatory systolic blood pressure during the daytime, and 1.27 (95 percent confidence interval, 1.07 to 1.57) for ambulatory systolic blood pressure during the nighttime. For ambulatory diastolic blood pressure, the corresponding relative risks of cardiovascular events associated with a 1-SD increment were 1.21 (95 percent confidence interval, 1.01 to 1.46), 1.24 (95 percent confidence interval, 1.03 to 1.49), and 1.18 (95 percent confidence interval, 0.98 to 1.40). CONCLUSIONS In patients with treated hypertension, a higher ambulatory systolic or diastolic blood pressure predicts cardiovascular events even after adjustment for classic risk factors including office measurements of blood pressure.
Web Service Recommendation with Ontology-based Similarity Measure

The concept of Web service recommendation is suggested in the present paper, i.e. using a computer system to dynamically offer the service requesters with services that potentially fit the requesters' persistent interests. Such service recommendation is supported by a lightweight semantic similarity assessment model between request and service advertisement, originated from the ontology-based conceptual similarity measure. The paper furthermore discusses a Web service recommendation framework, which utilizes the proposed similarity assessment model.
Ultrastructure of the spermatozoon of Calliobothrium verticillatum (Cestoda, Tetraphyllidea, Oncobothriidae)

The ultrastructure of the spermatozoon of Calliobothrium verticillatum (Cestoda, Tetraphyllidea, Oncobothriidae) parasite of the smoothhound shark, Mustelus mustelus L. (Pisces, Carcharhiniformes), was studied by transmission electron microscopy. This spermatozoon presents five regions characterized by several ultrastructural elements: an apical cone, a crested body, two axonemes of 9 + “1” pattern, electron-dense granules, a nucleus and cortical microtubules. In the present study, three of these features were the subject of a detailed attention. The first is the presence of two axonemes, which confirms that the Tetraphyllidea, Oncobothriidae possess two axonemes whereas the Tetraphyllidea, Phyllobothriidae possess only one axoneme. The second is the presence of one crested body, a criterion homogeneous in the Tetraphyllidea but heterogeneous among the different orders of Cestoda. The third is the number and the disposition of cortical microtubules. These three criteria seem to be interesting for phylogeny.
Review on Zoonotic Importance of Bovine Tuberculosis and Its Control

Bovine tuberculosis is a chronic infectious zoonotic disease of domestic animals and humans. It is characterized by formation of granulomas in tissue especially the lungs, lymph nodes, liver, intestines and the kidneys. Mycobacterium bovis is the main etiological agent of BTB (Bovine tuberculosis) which is an acid fast staining bacterium due to waxy substance (mycolic acid) present in its bacterial cell wall. The bacteria can be transmitted by both aerogenous and enterogenous routes. In Ethiopia bovine tuberculosis is endemic and mostly transmitted to humans through ingestion of unpasteurized contaminated milk and contact with infected animals. Disease causes development of miliary tubercular lesions, chronic cough, obstructions of air passages and alimentary tract or blood vessels and enlargement of lymph nodes. A spectrum of Cell-Mediated Immune responses (CMI) predominate infection, projecting the role of macrophages and T-cell populations. In advanced stage, there is increased humoral response. Tuberculinization test, single intradermal test and comparative intradermal test, is the valuable delayed type hyper sensitivity test used for diagnosing TB in live animal, and used in TB eradication and for international trade. Vaccination of calves with attenuated bovine-strain of tuberculosis bacterium, known as Bacillus of Calmette and Guerin (BCG) and testing and culling are important measure in BTB control and prevention endemic area like Ethiopia. It is important to pasteurize milk before human consumption to reduce public health risk.
ADAPTIVELY DENOISING DISCRETE TWO-WAY LAYOUTS

The two-way layout with ordinal or nominal factors is a fundamental datatype that is widespread in the sciences, engineering, and informatics. The unrestricted least squares estimator for the means of a two-way layout is usually inadmissible under quadratic loss and the model of homoscedastic independent Gaussian errors. In statistical practice, this least squares estimator may be modified by fitting hierarchical submodels and, for ordinal factors, by fitting polynomial submodels. ASP, an acronym for Adapative Shrinkage on Penalty bases, is an estimation (or denoising) strategy that chooses among submodel fits and more general shrinkage or smoothing fits to two-way layouts without assuming that any submodel is true. ASP fits distinguish between ordinal and nominal factors; respect the hierarchical decomposition of means into overall mean, main effects, and interaction terms; and are designed to reduce risk substantially over the unrestricted least squares estimator. For the balanced complete two-way layout, these points are developed through multiparametric asymptotics, in which the number of factor-level pairs tends to infinity, and through numerical case studies.
Full electrical characterization of aperiodic acoustic gratings by an enhanced /spl delta/-function model: theory and experiment

We derive the admittance of an aperiodic one-dimensional acoustic grating with acoustically matched boundaries using an enhanced /spl delta/-function model combined with the Green's function approach. The expression obtained is compared with the classical /spl delta/-function model and with electric back reflection measurements on a linearly chirped bulk acoustic grating with matched boundaries formed in LiNbO/sub 3/ by domain inversion and excited in "crossed-field" scheme. The agreement between calculated and measured results is excellent.
Latex-Induced allergic rhinitis in a laboratory nurse

Abstract A case of occupational rhinitis in association with natural rubber latex hypersensitivity is presented. In the nasal provocation test for natural rubber latex glove powder the nurse experienced rhinorrhoea. A significant increase in the amount of nasal secretion and mucosal oedema could be detected. The patient also showed a positive skin prick test to natural rubber latex allergens, and an elevated natural rubber specific IgE level in her serum. This, to our knowledge, has not been previously reported in the literature.