Miracle-dz/UniFAR-FTUs huggingface dataset:
[Polyphyllin I alleviates myocardial ischemia/reperfusion injury via nuclear factor-ΚB signal pathway].

OBJECTIVE To investigate the protective effect of Polyphyllin I (PPI) on myocardial ischemia/reperfusion (I/R) injury in rats and its mechanism. METHODS The 6-month-old Sprague-Dawley (SD) rats were divided into sham operation group (Sham group), I/R model group, and low, medium, high dose PPI groups according to the random number table method, with 10 in each group. The rat myocardial I/R model was prepared by ligating the left anterior descending branch of the coronary artery by 30 minutes and reperfusion by 120 minutes. Sham group was exposure to open chest without ligation. Low, medium, high dose PPI groups were injected with PPI 75, 150, 300 mg×kg-1×d-1 in front of the film for 4 weeks; dimethyl sulfoxide (DMSO) was gastric infused in the I/R model group. After the end of reperfusion, the myocardial infarction area (IA) was determined by triphenyltetrazole (TTC) and Evans blue (EB) staining; the apoptosis of myocardial cells was detected by TdT-mediated dUTP nick end labeling stain (TUNEL); the expressions of apoptosis related protein (Bax, Bcl-2), and cytoplasmic and nucleus expressions of P65 in nuclear factor-ΚB (NF-ΚB) signal pathway were detected by Western Blot. RESULTS Compared with the Sham group, the myocardial IA was significantly increased in the I/R model group, the apoptosis rate of myocardial cells was significantly increased, the expression of Bcl-2 was significantly decreased, and the expression of Bax was significantly increased, and the intranuclear transfer of P65 was significantly increased. Compared with the I/R model group, low, medium and high dose PPI pretreatment could significantly reduce the myocardial IA [(21.6±0.9)%, (14.3±1.6)%, (15.0±0.8)% vs. (29.6±1.4)%], the apoptosis rate of myocardial cells was significantly decreased [(38.6±1.9)%, (24.3±2.6)%, (26.3±2.8)% vs. (56.8±2.4)%], the protein expression of Bcl-2 was significantly increased, while the protein expression of Bax was significantly decreased (Bcl-2/GAPDH: 0.24±0.07, 0.36±0.02, 0.34±0.09 vs. 0.13±0.04; Bax/GAPDH: 0.39±0.10, 0.21±0.08, 0.23±0.06 vs. 0.53±0.12); and P65 nuclear transfer was significantly decreased after middle and high dose PPI pretreatment [nuclear P65/Histone 3: 0.49±0.09, 0.51±0.06 vs. 0.83±0.11; cytoplasmic P65/GAPDH: 0.31±0.03, 0.30±0.05 vs. 0.22±0.07], with statistically significant differences (all P < 0.05). However, there was no significant difference in each index between the medium and high dose PPI groups (all P > 0.05). CONCLUSIONS PPI alleviates myocardial I/R injury in rats via NF-ΚB signal pathway, and the PPI effect of 150 mg×kg-1×d-1 is most especially significant.
Machine Design and Calculation of OpticalPrecision Mount with Large-aperture

Based on the aim of enhancing the efficiency of three times frequency-conversion of laser of ns basic frequency impulse to 55 percent, this paper brings forward a new method of accuracy design with a high efficiency of frequency-conversion scheme and on the basis of this method we developed two frequency-conversion scheme with D380mm, large-aperture , which obtained prospective technical indexes and have been applied into the experiment of ICF.
Pharmacological Targeting of KCa Channels to Improve Endothelial Function in the Spontaneously Hypertensive Rat

Systemic hypertension is a major risk factor for the development of cardiovascular disease and is often associated with endothelial dysfunction. KCa2.3 and KCa3.1 channels are expressed in the vascular endothelium and contribute to stimulus-evoked vasodilation. We hypothesized that acute treatment with SKA-31, a selective activator of KCa2.x and KCa3.1 channels, would improve endothelium-dependent vasodilation and transiently lower mean arterial pressure (MAP) in male, spontaneously hypertensive rats (SHRs). Isolated vascular preparations exhibited impaired vasodilation in response to bradykinin (i.e., endothelial dysfunction) compared with Wistar controls, which was associated with decreased bradykinin receptor expression in mesenteric arteries. In contrast, similar levels of endothelial KCa channel expression were observed, and SKA-31 evoked vasodilation was comparable in vascular preparations from both strains. Addition of a low concentration of SKA-31 (i.e., 0.2–0.3 μM) failed to augment bradykinin-induced vasodilation in arteries from SHRs. However, responses to acetylcholine were enhanced. Surprisingly, acute bolus administration of SKA-31 in vivo (30 mg/kg, i.p. injection) modestly elevated MAP compared with vehicle injection. In summary, pharmacological targeting of endothelial KCa channels in SHRs did not readily reverse endothelial dysfunction in situ, or lower MAP in vivo. SHRs thus appear to be less responsive to endothelial KCa channel activators, which may be related to their vascular pathology.
Myosin IIA–mediated forces regulate multicellular integrity during vascular sprouting

Angiogenic sprouting is a critical process involved in vascular network formation within tissues. During sprouting, tip cells and ensuing stalk cells migrate collectively into the extracellular matrix while preserving cell–cell junctions, forming patent structures that support blood flow. Although several signaling pathways have been identified as controlling sprouting, it remains unclear to what extent this process is mechanoregulated. To address this question, we investigated the role of cellular contractility in sprout morphogenesis, using a biomimetic model of angiogenesis. Three-dimensional maps of mechanical deformations generated by sprouts revealed that mainly leader cells, not stalk cells, exert contractile forces on the surrounding matrix. Surprisingly, inhibiting cellular contractility with blebbistatin did not affect the extent of cellular invasion but resulted in cell–cell dissociation primarily between tip and stalk cells. Closer examination of cell–cell junctions revealed that blebbistatin impaired adherens-junction organization, particularly between tip and stalk cells. Using CRISPR/Cas9-mediated gene editing, we further identified NMIIA as the major isoform responsible for regulating multicellularity and cell contractility during sprouting. Together, these studies reveal a critical role for NMIIA-mediated contractile forces in maintaining multicellularity during sprouting and highlight the central role of forces in regulating cell–cell adhesions during collective motility.
Stigma, Anxiety, and Depression Among Gay and Bisexual Men in Mixed-Orientation Marriages

The mental health of gay and bisexual men in mixed-orientation marriages is poorly understood. In this article, the authors explore the development of anxiety and depression among gay and bisexual men in heterosexual marriages. Sixteen men, living in the Australian states of New South Wales, Queensland, Victoria, and Tasmania were interviewed throughout 2016 and 2017. An analysis of interviews identified four main themes, namely, compulsory heterosexuality, existential distress, compartmentalization, and integration and resolution. Participants reported experiencing anxiety and depression, which were exacerbated by the stigmatization of same-sex attraction and by an overwhelming distress from feelings of shame and guilt regarding their marital infidelity. Findings indicate that gay and bisexual men in mixed-orientation marriages develop anxiety and depression in response to the exigencies of compulsory heterosexuality and the compartmentalizing of same-sex attraction and identity during heterosexual marriage. Coming-out as same-sex attracted resolved men’s distress by facilitating an integrative self-structure.
Classical and quantum capacities of a fully correlated amplitude damping channel

We study information transmission over a fully correlated amplitude damping channel acting on two qubits. We derive the single-shot classical channel capacity and show that entanglement is needed to achieve the channel best performance. We discuss the degradability properties of the channel and evaluate the quantum capacity for any value of the noise parameter. We finally compute the entanglement-assisted classical channel capacity.
Could Fermion Masses Play a Role in the Stabilization of the Dilaton in Cosmology

We study the possibility that the Dilaton is stabilized by the contribution of fermion masses to its effective potential. We consider the Dilaton gravity action in four dimensions to which we add a mass term for a Dirac fermion. Such an action describes the interaction of the Dilaton with the fermions in the Yang-Mills sector of the coupled supergravity/super-Yang-Mills action which emerges as the low energy effective action of superstring theory after the extra spatial dimensions have been fixed. The Dilaton couples to the Fermion mass term via the usual exponential factor of this field which multiplies the non-kinetic terms of the matter Lagrangian, if we work in the Einstein frame. In the kinetic part of the Fermion action in the Einstein frame the Dilaton does not enter. Such masses can be generated in several ways: they can arise as a consequence of flux about internal spatial dimensions, they may arise as thermal fermion masses in a quasi-static phase in the early universe, and they will arise after the breaking of supersymmetry at late times. The vacuum contribution to the potential for the Dilaton is evaluated up to two loops. The result shows a minimum which could stabilize the Dilaton for reasonable ranges of parameter values.
A Randomized Clinical Trial Comparing the Impact of a Web-Based Multimedia Intervention Versus an Educational Pamphlet on Patient Outcomes in Breast Cancer Survivors with Chronic Secondary Lymphedema.

Objective: The purpose of this study was to evaluate the effects of a Web-based Multimedia Intervention (WBMI) for breast cancer-related lymphedema (BCRL) patients on symptom burden, function, psychological well-being, costs, and arm volume. Methods: Women with BCRL were randomized to intervention (n = 80) or control (n = 80) groups. The WBMI offered 12 modules, each of which took about 30 minutes to complete. The Pamphlet took about 2 hours to read. Data on symptom burden, psychological well-being, function, and costs were collected preintervention; and 1, 3, 6, and 12 months postintervention. A subgroup of 45 regional patients had arm extracellular fluid measured by bioimpedance at baseline and at 3, 6, and 12 months postintervention. Intervention perceived value was also captured. Results: A statistically significant difference (p = 0.011) was observed for rates of intervention completion, WBMI (58%), and Pamphlet (77%). With the exception of the number of biobehavioral symptoms (mood), no statistically significant differences between groups in symptom reduction were apparent between baseline and 1 or 12 months (effect sizes = 0.05-0.28, p > 0.05) based on the Lymphedema Symptom Intensity and Distress Scale-Arm (LSIDS-A). No statistically significant differences between the groups were observed for changes in other variables. The WBMI was perceived as providing better self-care information than the Pamphlet (p = 0.001). Conclusions: WBMI participants experienced improved biobehavioral symptoms and higher perceived quality of information. The lack of significant differences on other variables may be due to the high percentage of participants who did not complete the WBMI.
Adverse childhood experiences (ACEs) and cardiovascular development from childhood to early adulthood: study protocol of the Niagara Longitudinal Heart Study

Introduction Recent reviews have found substantial links between a toxic childhood environment including child abuse and severe household dysfunction and adult cardiovascular disease (CVD). Collectively referred to as adverse childhood experiences (ACEs), this toxic environment is prevalent among children, with recent Canadian estimates of child abuse at 27%–32%, and severe household dysfunction at 49%. Based on these prevalence rates, the potential effect of ACEs on CVD is more significant than previously thought. Yet, how ACEs amplify the risk for later CVD remains unclear. Lifestyle risk factors only partially account for this connection, instead directing attention to the interaction between psychosocial factors and physiological mechanisms such as inflammation. The Niagara Longitudinal Heart Study (NLHS) examines how ACEs influence cardiovascular health (CVH) from childhood to early adulthood. Integrating the stress process and biological embedding models, this study examines how psychosocial and physiological factors in addition to lifestyle factors explain the relationship between ACEs and CVH. Methods This follow-up study combines three baseline studies from 2007 to 2012 that collected CVH measures including child blood pressure, heart rate, left ventricular structure and function, arterial stiffness indices and baroreflex sensitivity on 564 children. Baseline data also include anthropometric, biological, lifestyle, behavioural, and psychosocial measures that varied across primary studies. Now over 18 years of age, we will recruit and retest as many participants from the baseline studies as possible collecting data on ACEs, CVH, anthropometric, lifestyle and psychosocial measures as well as blood, saliva and hair for physiological biostress markers. Ethics and dissemination Ethics approval has been received for the NLHS follow-up. Written consent to participate in the follow-up study is obtained from each participant. Results testing all proposed hypotheses will be submitted for publication in peer-reviewed journals.
Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development

Maternal infection and fever during pregnancy have been implicated in the etiology of autism spectrum disorder (ASD); however, studies have not been able to separate the effects of fever itself from the impact of a specific infectious organism on the developing brain. We utilized data from the Study to Explore Early Development (SEED), a case–control study among 2‐ to 5‐year‐old children born between 2003 and 2006 in the United States, to explore a possible association between maternal infection and fever during pregnancy and risk of ASD and other developmental disorders (DDs). Three groups of children were included: children with ASD (N = 606) and children with DDs (N = 856), ascertained from clinical and educational sources, and children from the general population (N = 796), randomly sampled from state birth records. Information about infection and fever during pregnancy was obtained from a telephone interview with the mother shortly after study enrollment and maternal prenatal and labor/delivery medical records. ASD and DD status was determined by an in‐person standardized developmental assessment of the child at 3–5 years of age. After adjustment for covariates, maternal infection anytime during pregnancy was not associated with ASD or DDs. However, second trimester infection accompanied by fever elevated risk for ASD approximately twofold (aOR = 2.19, 95% confidence interval 1.14–4.23). These findings of an association between maternal infection with fever in the second trimester and increased risk of ASD in the offspring suggest that the inflammatory response to the infectious agent may be etiologically relevant. Autism Res 2019, 12: 1551–1561. © 2019 International Society for Autism Research, Wiley Periodicals, Inc.
Modulation of the Hoffmann reflex in the tibialis anterior with a change in posture

Hoffmann (H‐) reflex amplitudes in plantar flexor soleus muscle are modulated by posture, yet dorsiflexor tibialis anterior (TA) H‐reflex parameters have sparingly been studied. The purpose was to investigate modulation of the TA H‐reflex when postural demands are increased from sitting to standing. In this study, data from 18 participants (Age: 25 ± 4 years, Height: 170.9 ± 9.5 cm, Weight: 75.9 ± 17.2 kg) allowed comparison of two experimental conditions involving different postures (i.e. sitting and standing). Maximal amplitude of the TA H‐reflex (Hmax) as a percent of the maximal M‐wave amplitude (Mmax) (Hmax (% Mmax)) during sitting and standing was compared using ANOVA. Modulation of TA H‐reflex amplitude was found: Eleven participants showed facilitation and seven showed no change of reflex amplitudes. Only participants in the facilitation group showed modulation related to changes in posture (sitting: 8.7 ± 2.9%; standing: 14.8 ± 6.7%, P = 0.005). These data provide evidence of the sensitivity to posture of TA H‐reflexes. As with task‐dependent changes in soleus H‐reflexes, presynaptic regulation of Ia afferent transmission is a possible mechanism. Further investigations into causes of modulation are warranted.
The CP-violating type-II 2HDM and Charged Higgs boson benchmarks

We review and update the interpretation of the 125 GeV scalar as the lightest Higgs boson of the Two-Higgs-Doublet Model, allowing for CP violation in the potential. The detection of a charged Higgs boson would exclude the Standard Model. Proposed benchmarks for charged-Higgs searches in the channel pp\to H^+W^-X\to W^+W^-H_1X are reviewed and updated.
Language for Implementing Multiagent Transportation Applications

The multiagent paradigm is well suited to designing transportation applications. However, when implementing such applications in highly dynamic environments, it is very costly to use languages relying on channel-based communication. Data driven coordination languages rely on a shared space in which agents add, read and retrieve data. They are intuitively relevant for distributed transportation applications, where dierent actors evolve in a highly dynamic and very constrained environment. However, existing coordination languages can hardly be used for transportation applications. Indeed, they on the one side fail to express agents complex interaction needs and to ensure secure data exchanges. Indeed, in transportation applications, the interaction needs of the agents are driven by their current context and by ambient conditions, and information security is usually important. In this article, we propose a data driven coordination language tackling these issues, and we illustrate our proposal with two applications: a traveler information system and a demand-responsive transport system. We also dene a programming language on top of Java allowing to use the language syntax while executing it in Java.
DGAT2 partially compensates for lipid-induced ER stress in human DGAT1-deficient intestinal stem cells[S]

Dietary lipids are taken up as FAs by the intestinal epithelium and converted by diacylglycerol acyltransferase (DGAT) enzymes into triglycerides, which are packaged in chylomicrons or stored in cytoplasmic lipid droplets (LDs). DGAT1-deficient patients suffer from vomiting, diarrhea, and protein losing enteropathy, illustrating the importance of this process to intestinal homeostasis. Previously, we have shown that DGAT1 deficiency causes decreased LD formation and resistance to unsaturated FA lipotoxicity in patient-derived intestinal organoids. However, LD formation was not completely abolished in patient-derived organoids, suggesting the presence of an alternative mechanism for LD formation. Here, we show an unexpected role for DGAT2 in lipid metabolism, as DGAT2 partially compensates for LD formation and lipotoxicity in DGAT1-deficient intestinal stem cells. Furthermore, we show that (un)saturated FA-induced lipotoxicity is mediated by ER stress. More importantly, we demonstrate that overexpression of DGAT2 fully compensates for the loss of DGAT1 in organoids, indicating that induced DGAT2 expression in patient cells may serve as a therapeutic target in the future.
A Holographic Path to the Turbulent Side of Gravity

We study the dynamics of a 2+1 dimensional relativistic viscous conformal fluid in Minkowski spacetime. Such fluid solutions arise as duals, under the "gravity/fluid correspondence", to 3+1 dimensional asymptotically anti-de Sitter (AAdS) black brane solutions to the Einstein equation. We examine stability properties of shear flows, which correspond to hydrodynamic quasinormal modes of the black brane. We find that, for sufficiently high Reynolds number, the solution undergoes an inverse turbulent cascade to long wavelength modes. We then map this fluid solution, via the gravity/fluid duality, into a bulk metric. This suggests a new and interesting feature of the behavior of perturbed AAdS black holes and black branes, which is not readily captured by a standard quasinormal mode analysis. Namely, for sufficiently large perturbed black objects (with long-lived quasinormal modes), nonlinear effects transfer energy from short to long wavelength modes via a turbulent cascade within the metric perturbation. As long wavelength modes have slower decay, this lengthens the overall lifetime of the perturbation. We also discuss various implications of this behavior, including expectations for higher dimensions, and the possibility of predicting turbulence in more general gravitational scenarios.
Ultra-Cold Dipolar Gases

We present a concise review of the physics of ultra-cold dipolar gases, based mainly on the theoretical developments in our own group. First, we discuss shortly weakly interacting ultra-cold trapped dipolar gases. Dipolar Bose-Einstein condensates exhibit non-standard instabilities and the physics of both Bose and Fermi dipolar gases depends on the trap geometry. We focus then the second part of the paper on strongly correlated dipolar gases and discuss ultra-cold dipolar gases in optical lattices. Such gases exhibit a spectacular richness of quantum phases and metastable states, which may perhaps be used as quantum memories. We comment shortly on the possibility of superchemistry aiming at the creation of dipolar heteronuclear molecules in lattices. Finally, we turn to ultra-cold dipolar gases in artificial magnetic fields, and consider rotating dipolar gases, that provide in our opinion the best option towards the realization of the fractional quantum Hall effect and quantum Wigner crystals.
Foundations Of Potential Theory

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Placenta Stem/Stromal Cell–Derived Extracellular Vesicles for Potential Use in Lung Repair

Many acute and chronic lung injuries are incurable and rank as the fourth leading cause of death globally. While stem cell treatment for lung injuries is a promising approach, there is growing evidence that the therapeutic efficacy of stem cells originates from secreted extracellular vesicles (EVs). Consequently, EVs are emerging as next‐generation therapeutics. While EVs are extensively researched for diagnostic applications, their therapeutic potential to promote tissue repair is not fully elucidated. By housing and delivering tissue‐repairing cargo, EVs refine the cellular microenvironment, modulate inflammation, and ultimately repair injury. Here, the potential use of EVs derived from two placental mesenchymal stem/stromal cell (MSC) lines is presented; a chorionic MSC line (CMSC29) and a decidual MSC cell line (DMSC23) for applications in lung diseases. Functional analyses using in vitro models of injury demonstrate that these EVs have a role in ameliorating injuries caused to lung cells. It is also shown that EVs promote repair of lung epithelial cells. This study is fundamental to advancing the field of EVs and to unlock the full potential of EVs in regenerative medicine.