Miracle-dz/UniFAR-FTUs huggingface dataset:
Significant Enhancement of the Visible Light Photocatalytic Properties in 3D BiFeO3/Graphene Composites

Bismuth ferrite (BiFeO3, BFO) submicron cubes and 3D BFO/graphene composite materials were synthesized by a simple hydrothermal process. The crystallization processes of the 3D BFO/graphene composites with different graphene oxide (GO) concentrations were studied for their visible light photocatalytic properties. Compared to the single BFO submicron cubes, 3D BFO/graphene composites have greatly improved photocatalytic activity. A high photocatalytic performance is obtained at a GO concentration of 3 mg/mL, with the degradation rate of methylene blue (MB) dye reaching up to 92% in 140 min. The enhancement of photocatalytic activity can be attributed to the large specific surface area and 3D architecture of 3D composites, which provide more transport paths to effectively improve the separation rate of photo-generated electrons and holes. Therefore, 3D BFO/graphene composites have a broad prospect of application in the field of photocatalysis.
Bacterial Dispersers along Preferential Flow Paths of a Clay Till Depth Profile

The ability to disperse is considered essential for soil bacteria colonization and survival, yet very little is known about the dispersal ability of communities from different heterogeneous soil compartments. Important factors for dispersal are the thickness and connectivity of the liquid film between soil particles. The present results from a fractured clay till depth profile suggest that dispersal ability is common in various soil compartments and that most are dominated by a few dispersing taxa. Importantly, an increase in shared dispersers among the preferential flow paths of the clay till suggests that active dispersal plays a role in the successful colonization of these habitats. ABSTRACT This study assessed the dispersal of five bacterial communities from contrasting compartments along a fractured clay till depth profile comprising plow layer soil, preferential flow paths (biopores and the tectonic fractures below), and matrix sediments, down to 350 cm below the surface. A recently developed expansion of the porous surface model (PSM) was used to capture bacterial communities dispersing under controlled hydration conditions on a soil-like surface. All five communities contained bacteria capable of active dispersal under relatively low hydration conditions (−3.1 kPa). Further testing of the plow layer community revealed active dispersal even at matric potentials of −6.3 to −8.4 kPa, previously thought to be too dry for dispersal on the PSM. Using 16S rRNA gene amplicon sequencing, the dispersing communities were found to be less diverse than their corresponding total communities. The dominant dispersers in most compartments belonged to the genus Pseudomonas and, in the plow layer soil, to Rahnella as well. An exception to this was the dispersing community in the matrix at 350 cm below the surface, which was dominated by Pantoea. Hydrologically connected compartments shared proportionally more dispersing than nondispersing amplicon sequence variants (ASVs), suggesting that active dispersal is important for colonizing these compartments. These results highlight the importance of including soil profile heterogeneity when assessing the role of active dispersal and contribute to discerning the importance of active dispersal in the soil environment. IMPORTANCE The ability to disperse is considered essential for soil bacteria colonization and survival, yet very little is known about the dispersal ability of communities from different heterogeneous soil compartments. Important factors for dispersal are the thickness and connectivity of the liquid film between soil particles. The present results from a fractured clay till depth profile suggest that dispersal ability is common in various soil compartments and that most are dominated by a few dispersing taxa. Importantly, an increase in shared dispersers among the preferential flow paths of the clay till suggests that active dispersal plays a role in the successful colonization of these habitats.
Strategies in the transfer of varying grades of vitrified‐warmed blastocysts in women aged over 35 years: A propensity‐matched analysis

For in vitro fertilization, the optimal number of blastocysts to transfer according to blastocyst grade has not been well established, especially with respect to vitrified‐warmed blastocyst transfer (VBT) in women aged over 35 years. This study aimed to compare the pregnancy and neonatal outcomes for three different VBT methods with variable numbers and qualities of blastocysts in women aged over 35 years.
Tracking Structural Self‐Reconstruction and Identifying True Active Sites toward Cobalt Oxychloride Precatalyst of Oxygen Evolution Reaction

Unravelling the intrinsic mechanism of electrocatalytic oxygen evolution reaction (OER) by use of heterogeneous catalysts is highly desirable to develop related energy conversion technologies. Albeit dynamic self‐reconstruction of the catalysts during OER is extensively observed, it is still highly challenging to operando probe the reconstruction and precisely identify the true catalytically active components. Here, a new class of OER precatalyst, cobalt oxychloride (Co2(OH)3Cl) with unique features that allow a gradual phase reconstruction during OER due to the etching of lattice anion is demonstrated. The reconstruction continuously boosts OER activities. The reconstruction‐derived component delivers remarkable performance in both alkaline and neutral electrolytes. Operando synchrotron radiation‐based X‐ray spectroscopic characterization together with density functional theory calculations discloses that the etching of lattice Cl− serves as the key to trigger the reconstruction and the boosted catalytic performance roots in the atomic‐level coordinatively unsaturated sites (CUS). This work establishes fundamental understanding on the OER mechanism associated with self‐reconstruction of heterogeneous catalysts.
Short exposure to oxygen and sulfide alter nitrification, denitrification, and DNRA activity in seasonally hypoxic estuarine sediments

&NA; Increased organic loading to sediments from eutrophication often results in hypoxia, reduced nitrification and increased production of hydrogen sulfide, altering the balance between nitrogen removal and retention. We examined the effect of short‐term exposure to various oxygen and sulfide concentrations on sediment nitrification, denitrification and DNRA from a chronically hypoxic basin in Roskilde Fjord, Denmark. Surprisingly, nitrification rates were highest in the hypoxic and anoxic treatments (about 5 &mgr;mol cm−3 d−1) and the high sulfide treatment was not significantly different than the oxic treatment. Denitrification in the hypoxic treatment was highest at 1.4 &mgr;mol cm−3 d−1 and significantly higher than the high sulfide treatment. For DNRA, the rate in high sulfide treatment was 2 &mgr;mol cm−3 d−1. This was significantly higher than all oxygen treatments that were near zero. In this system, nitrifiers rapidly recovered from conditions typically considered inhibiting, while denitrifiers had a more muted response. DNRA bacteria appear to depend on sulfide for nitrate reduction. Anammox was insignificant. Thus, in estuaries and coastal systems that experience short‐term variations in oxygen and sulfide, capabilities of microbial communities are more diverse and tolerant of suboptimal conditions than some paradigms suggest.
Athenian Eye Cups in Context

Since the late 1970s, scholars have explored Athenian eye cups within the presumed context of the symposion, privileging a hypothetical Athenian viewer and themes of masking and play. Such emphases, however, neglect chronology and distribution, which reveal the complexity of the pottery trade during the late sixth and the fifth centuries B.C.E. Although many eye cups have been found in Athens—namely on the Acropolis and mainly from late in the series—the majority come from funerary, sanctuary, and domestic contexts to the west and east. Most of the earliest, largest, and highest-quality examples were exported to Etruria, where the symposion as the Athenians knew it did not exist. Workshops and traders were clearly aware of their audiences at home and abroad and shifted production and distribution of vases to suit. The Etruscan consumers of eye cups made conscious choices regarding their purchase and use. Tomb assemblages from Vulci and elsewhere reveal their multivalent significance: they are emblematic of banqueting in life and death, apotropaic entities, likely with ritual uses. Rather than being signs of hellenization in a foreign culture, Athenian eye cups—like all Greek vases—were brought into Etruria, then integrated, manipulated, and even transformed to suit local needs and beliefs.
Methane-Rich Saline Protects Against Sepsis-Induced Liver Damage by Regulating The PPAR-γ/NF-κB Signaling Pathway.

Sepsis, a life-threatening organ dysfunction due to a dysregulated response to infection, is a common complication of major surgery. Previous studies have showed that methane possesses protective properties. This study aims to investigate the protective effect of methane-rich saline (MRS) on sepsis-induced liver injury. In an in vivo experiment, C57BL/6 mice received cecal ligation and puncture to create a septic model followed by MRS treatment (10 ml/kg, ip treatment) 30 min and 12 h after the operation. We found that methane effectively decreased the serum aspartate aminotransferase, alanine aminotransferase and liver index, as well as the liver pathological damage, and reduced the localized infiltration of inflammatory cells. Methane suppressed the expression of the TLR4/ NF-κB signaling pathway and stimulated the expression of PPAR-γ during sepsis, which inhibited the activation of NF-κB and decreased the level of inflammatory cytokines, such as tumor necrosis factor-α, interleukin-6 and interleukin-1β. Moreover, we found that MRS treatment relieved ROS damage by upregulating heme oxygenase-1, superoxide dismutase and glutathione, and downregulating malondialdehyde, which was consistent with the results of DHE fluorescent staining. MRS treatment also regulated apoptosis-related proteins, such as Bax, Bcl-2 and caspase-3. In the in vitro experiment, HepG2 cells received inflammatory stimulation induced by LPS followed by methane-rich medium (MRM) treatment. We found that MRM alleviated the inflammatory damage, ROS damage and regulated the expression of PPAR-γ/NF-κB. Our data indicated that methane treatment prevented liver damage in sepsis via anti-inflammatory, anti-oxidative, and anti-apoptotic properties that involved the PPAR-γ/ NF-κB signaling pathway.
Influence of genetic variants of gamma interferon, interleukins 10 and 12 on Visceral Leishmaniasis in an endemic area, Iran

ABSTRACT Visceral leishmaniasis (VL) is a life threatening disease in which a variety of cytokines regulating the immune responses can determine its outcome. As based on their region in the gene, some single nucleotide polymorphisms (SNP) can influence the expression of their corresponding proteins, this study aimed to investigate the association between SNP in the IL-10, IL-12, IFN-γ genes and susceptibility to VL. The study was carried out on 120 patients with VL, 67 patients’ families (family group), and 102 healthy individuals with positive leishmanin skin test as positive control group. SNPs in IL-10 (−592, −819, −1082), IL-12 (+1188) were analyzed using PCR-RFLP and allele specific polymerase chain reaction (ASPCR) was used to analyze SNPs in IFN-γ (+874 A/T). The results showed that at position +874 of IFN-γ, AT genotype was significantly more frequent in patients than that in families and controls, but TT genotype was significantly more frequent in families than in patients. Distributions of IFN-γ alleles were not significantly different between the study groups. As for IL-12 and IL-10 genotypes and alleles, no significant difference was observed between the groups. Although a strong linkage disequilibrium was observed between alleles −592, −819 and −1082 of IL-10, distributions of the most common haplotypes and haplogenotypes reconstructed from IL-10 alleles were not significantly different between the study groups. It could be suggested that heritage of AT genotype at position +874 of IFN-γ may predispose and TT genotype can resist individual to VL in an endemic area in the southwest of Iran.
State of the Art and Perspectives on Silicon Photonic Switches

In the last decade, silicon photonic switches are increasingly believed to be potential candidates for replacing the electrical switches in the applications of telecommunication networks, data center and high-throughput computing, due to their low power consumption (Picojoules per bit), large bandwidth (Terabits per second) and high-level integration (Square millimeters per port). This review paper focuses on the state of the art and our perspectives on silicon photonic switching technologies. It starts with a review of three types of fundamental switch engines, i.e., Mach-Zehnder interferometer, micro-ring resonator and micro-electro-mechanical-system actuated waveguide coupler. The working mechanisms are introduced and the key specifications such as insertion loss, crosstalk, switching time, footprint and power consumption are evaluated. Then it is followed by the discussion on the prototype of large-scale silicon photonic fabrics, which are based on the configuration of above-mentioned switch engines. In addition, the key technologies, such as topological architecture, passive components and optoelectronic packaging, to improve the overall performance are summarized. Finally, the critical challenges that might hamper the silicon photonic switching technologies transferring from proof-of-concept in lab to commercialization are also discussed.
Down‐regulated expression of microRNA‐338‐5p contributes to neuropathology in Alzheimer's disease

Alzheimer's disease (AD) is a leading cause of dementia. However, the mechanisms responsible for development of AD, especially for the sporadic variant, are still not clear. In our previous study, we discovered that a small noncoding RNA (miR‐188‐3p) targeting β‐site amyloid precursor protein cleaving enzyme (BACE)‐l, a key enzyme responsible for Aβ formation, plays an important role in the development of neuropathology in AD. In the present study, we identified that miR‐338‐5p, a new miRNA that also targets BACE1, contributes to AD neuropathology. We observed that expression of miR‐338‐5p was significantly down‐regulated in the hippocampus of patients with AD and 5XFAD transgenic (TG) mice, an animal model of AD. Overexpression of miR‐338‐5p in the hippocampus of TG mice reduced BACE1 expression, Aβ formation, and neuroinflammation. Overexpression of miR‐338‐5p functionally prevented impairments in long‐term synaptic plasticity, learning ability, and memory retention in TG mice. In addition, we provide evidence that down‐regulated expression of miR‐338‐5p in AD is regulated through the NF‐κB signaling pathway. Our results suggest that down‐regulated expression of miR‐338‐5p plays an important role in the development of AD. —Qian, Q. , Zhang, J., He, F. ‐P., Bao, W. ‐X. , Zheng, T. ‐T. , Zhou, D. ‐M. , Pan, H. ‐Y. , Zhang, H. , Zhang, X. ‐Q. , He, X. , Sun, B. ‐G. , Luo, B. ‐Y. , Chen, C. , Peng, G. ‐P. Down‐regulated expression of microRNA‐338‐5p contributes to neuropathology in Alzheimer's disease. FASEB J. 33,4404–4417 (2019). www.fasebj. org
Non-circular home ranges and the estimation of population density.

Spatially explicit capture-recapture (SECR) models have emerged as one solution to the problem of estimating the population density of mobile and cryptic animals. Spatial models embody assumptions regarding the spatial distribution of individuals and the spatial detection process. The detection process is modeled in SECR as a radial decline in detection probability with distance from the activity center of each individual. This would seem to require that home ranges are circular. The robustness of SECR when home ranges are not circular has been the subject of conflicting statements. Ivan et al. previously compared the SECR density estimator to a telemetry-scaled non-spatial estimator. I suggest that the apparent non-robustness of SECR in their study was a simulation artefact. New simulations of elliptical home ranges establish that the SECR density estimator is largely robust to non-circularity when detectors are spread in two dimensions, but may be very biased if the detector array is linear and home ranges align with the array. Transformation to isotropy reduces bias from designs of intermediate dimension, such as hollow square arrays. Possible alignment of home ranges should be considered when designing detector arrays.
Development of a rapid and sensitive recombinase polymerase amplification‐lateral flow assay for detection of Burkholderia mallei

Burkholderia mallei, a potential biothreat agent is the aetiological agent of glanders, a zoonotic disease primarily affecting equines. B. mallei shares close genetic proximity with B. pseudomallei, the aetiological agent of melioidosis. Hence, molecular detection of B. mallei and its differentiation from B. pseudomallei has always been challenging. Early diagnosis of glanders is critical for timely treatment in humans and disease containment in animals. In this study a recombinase polymerase amplification-lateral flow (RPA-LF) assay has been developed for early and accurate detection of B. mallei. RPA-LF assay was found to be highly sensitive and detected as low as 10 fg genomic DNA of B. mallei. The assay was highly specific and could differentiate B. mallei and B. pseudomallei. The assay also detected B. mallei in artificially spiked blood, tap water and garden soil. The established assay is simple, rapid and does not require complex instrumentation. The field deployable assay can have better implications in rapid glanders diagnosis and environmental detection of B. mallei over PCR-based detection tools in glanders endemic areas with limited laboratory resources.
Fluconazole as an Antifungal Genitourinary Irrigant

Abstract: Persistent funguria may cause significant morbidity and potential mortality. Both amphotericin B as a urinary irrigant and systemic fluconazole have been effective therapeutic agents. In cases when amphotericin supplies are limited by manufacturing shortfall or when renal insufficiency lessens urine levels of fluconazole, other antifungal treatment modalities may be necessary. Fluconazole used as a genitourinary irrigant has been reported as an effective antifungal bladder irrigant. In this study, 6 patients were treated with fluconazole bladder irrigant. Four patients had a complete response, 1 patient required a second course of treatment, and 1 patient did not respond. Further study is necessary to determine whether fluconazole is effective in the management of candiduria caused by non-albicans species. Amphotericin B should remain in the armamentarium of the treating physician. Present-day drug costs are comparable.
Metabolic factors and the risk of colorectal cancer by KRAS and BRAF mutation status

Factors related to energy metabolism and the metabolic syndrome, such as higher body mass index (BMI), blood glucose, or blood lipids, and blood pressure, are associated with an increased risk of colorectal cancer (CRC). However, CRC is a heterogeneous disease, developing through distinct pathways with differences in molecular characteristics and prognosis, and possibly also in risk factors. For subtypes defined by KRAS and BRAF mutation status, BMI is the only metabolic factor previously studied, with inconsistent findings. We investigated whether associations between BMI, blood glucose, blood lipids, and blood pressure and CRC risk differed by tumor KRAS and BRAF mutation status in 117,687 participants from two population‐based cohorts within the Northern Sweden Health and Disease Study (NSHDS). Hazard ratios (HRs) for overall CRC and CRC subtypes by metabolic factors were estimated with Cox proportional hazards regression, using multiple imputation to handle missing exposure and tumor data. During a median follow‐up of 15.6 years, we acquired 1,250 prospective CRC cases, of which 766 cases had complete baseline and molecular tumor data. Consistent with previous evidence, higher BMI, total cholesterol, triglyceride levels, and blood pressure were associated with an increased risk of overall CRC (HRs per 1 standard deviation increase: 1.07 to 1.12). These associations were similar regardless of CRC subtype by KRAS and BRAF mutation status (all pheterogeneity > 0.05). The same was true for subtypes based on microsatellite instability status. Poor metabolic health may therefore be a universal mechanism for colorectal cancer, acting across multiple developmental pathways.
Linking Termite Feeding Preferences and Soil Physical Functioning in Southern-Indian Woodlands

Termites are undoubtedly amongst the most important soil macroinvertebrate decomposers in semi-arid environments in India. However, in this specific type of environment, the influence of termite foraging activity on soil functioning remains unexplored. Therefore, this study examines the link between the quality of litter and the functional impact of termite feeding preferences on soil properties and soil hydraulic conductivity in a deciduous forest in southern India. Different organic resources (elephant dung: “ED”, elephant grass: “EG”, acacia leaves: “AL” and layers of cardboard: “CB”) were applied on repacked soil cores. ED appeared to be the most attractive resource to Odontotermes obesus, leading to a larger amount of soil sheeting (i.e., the soil used by termites for covering the litter they consume), more numerous and larger holes in the ground and a lower soil bulk density. As a consequence, ED increased the soil hydraulic conductivity (4-fold) compared with the control soil. Thus, this study highlights that the more O. obesus prefers a substrate, the more this species impacts soil dynamics and water infiltration in the soil. This study also shows that ED can be used as an efficient substrate for accelerating the infiltration of water in southern-Indian soils, mainly through the production of galleries that are open on the soil surface, offering new perspectives on termite management in this environment.
FAK alternative splice mRNA variants expression pattern in colorectal cancer

The Focal adhesion kinase (FAK) is a ubiquitous cytoplasmic tyrosine‐kinase promoting tumor progression and metastasis processes by acting in cancer cells and their tumor microenvironment partners. FAK overexpression in primary colon tumors and their metastasis is associated to poor colorectal cancer (CRC) patients’ outcome. Eight FAK mRNA alternative splice variants have been described and contribute to additional level of FAK activity regulation, some of them corresponding to overactivated FAK isoforms. To date, FAK mRNA alternative splice variants expression and implication in CRC processes remain unknown. Here, using different human CRC cells lines displaying differential invasive capacities in an in vivo murine model recapitulating the different steps of CRC development from primary tumors to liver and lung metastasis, we identified three out of the eight mRNA variants (namely FAK0, FAK28 and FAK6) differentially expressed along the CRC process and the tumor sites. Our results highlight an association between FAK0 and FAK6 expressions and the metastatic potential of the most aggressive cell lines HT29 and HCT116, suggesting that FAK0 and FAK6 could represent aggressiveness markers in CRC. Our findings also suggest a more specific role for FAK28 in the interactions between the tumors cells and their microenvironment. In conclusion, targeting FAK0, the common form of FAK, might not be a good strategy based on the numerous roles of this kinase in physiological processes. In contrast, FAK6 or FAK28 splice variants, or their corresponding protein isoforms, may putatively represent future therapeutic target candidates in the development of CRC primary tumors and metastasis.