Miracle-dz/UniFAR-FTUs huggingface dataset:
All-on-Four Concept in Dental Implants

A common condition in elderly patients is the occurrence of edentulism, which can be the result of many factors such as poor oral hygiene, dental caries, and periodontal disease. The rehabilitation of edentulous jaws with guided and flapless surgery applied to the all-on-4 concepts is a predictable treatment with a high implant and prosthetic survival rates. However, there are several contraindications for this technique; one of the most important is when bone reduction is necessary due to a gummy smile in the maxilla or when an irregular or thin bone crest in the jaws prevents a correct treatment.
Protease-MediatedMaturation of HIV : Inhibitors of Protease and theMaturation Process

Protease-mediated maturation of HIV-1 virus particles is essential for virus infectivity. Maturation occurs concomitant with immature virus particle release and is mediated by the viral protease (PR), which sequentially cleaves the Gag and Gag-Pol polyproteins into mature protein domains. Maturation triggers a second assembly event that generates a condensed conical capsid core. The capsid core organizes the viral RNA genome and viral proteins to facilitate viral replication in the next round of infection. The fundamental role of proteolytic maturation in the generation of mature infectious particles has made it an attractive target for therapeutic intervention. Development of small molecules that target the PR active site has been highly successful and nine protease inhibitors (PIs) have been approved for clinical use. This paper provides an overview of their development and clinical use together with a discussion of problems associated with drug resistance. The second-half of the paper discusses a novel class of antiretroviral drug termed maturation inhibitors, which target cleavage sites in Gag not PR itself. The paper focuses on bevirimat (BVM) the first-in-class maturation inhibitor: its mechanism of action and the implications of naturally occurring polymorphisms that confer reduced susceptibility to BVM in phase II clinical trials.
Evaluation of thermal runaway control based on frequency modulated carrier wave in parametric array loudspeaker

A parametric array loudspeaker (PAL) can realize a sharper directivity by utilizing an ultrasound wave (carrier wave). The conventional PAL has a problem that ultrasonic transducers cause thermal runaway by strongly emitting an amplitude modulated (AM) wave through a long period of time. As a result, spectral peak noises are generated from the PAL including the ultrasonic transducer in which thermal runaway has occurred. Therefore, we have proposed a thermal runaway control method with a frequency modulated carrier wave. In the proposed method, we generate the AM wave with the frequency modulated carrier wave that the frequency of the carrier wave changes with time. By changing the frequency of the carrier wave with time, we can reduce the spectral peak noises and minimize the effects of thermal runaway in ultrasonic transducers. In the paper, to evaluate the effects of thermal runaway, we perform evaluation experiments for the power of the spectral peak noises with the conventional and the proposed methods. Specifically, we measured the time transition of the power of the spectral peak noises when emitting the frequency modulated carrier wave from the PAL for 20 minutes. Finally, we confirmed the effectiveness of the proposed method.
Cornea Autoantibodies Contribute to the Immunopathogenesis of Experimental Dry Eye Disease

METHODS. Dry eye was induced by exposing female C57BL/6 wild-type mice or hen egg lysozyme B-cell receptor transgenic mice to desiccating stress (subcutaneous scopolamine [0.5 mg/ 0.2 mL] 3 times a day, humidity < 40%, and sustained airflow) for 3 weeks, allowing sufficient time for a humoral immune response. Serum or purified IgG isolated from dry-eye mice or untreated controls was passively transferred to nude recipient mice, which were evaluated for ocular surface inflammation 3 days after transfer. To determine if complement activation contributed to serum-induced dry eye disease, cobra venom factor was used to deplete complement activity.
Media Tone Effect and Return Drift following Ambiguous News

We construct media tone measures from 53,856 newspaper articles about non-financial S&P 500 firms between 2004 and 2013, and find that firms with low-negative-tone articles in the previous months generate higher returns in the following months than firms with high-negative-tone articles. This media tone effect is primarily driven by abnormal returns of high-negative stocks. There is persistent return drift for high-negative stocks following ambiguous public information. Market frictions, slow information diffusion, and investor biases are possible explanations of underreaction in the short term, but in the medium to long term, the media may help correct mispricing based on private signals.
Assessment of the toxicity of selected Australian native plant extracts using the Artemia franciscana nauplii bioassay

Thirty nine methanolic extracts from twenty five Australian native plants were investigated for toxicity using the Artemia franciscana nauplii lethality bioassay and compared to the reference toxins potassium dichromate and Mevinphos. 7 extracts (18 %) showed marked lethality towards Artemia franciscana nauplii at 24 h, 11 extracts (28 %) at 48 h and 19 extracts (49 %) at 72 h. Of the positive controls, only Mevinphos displayed significant lethality at 24 h. Potassium dichromate treatment resulted in only approximately 10 % mortality at 24 h but induced 100% mortality by 48 h. Of the non-toxic extracts, A. aulacocarpa leaf, L. bracteata leaf, L. juniperium leaf and flower, S. australe leaf and B. celsissima leaf extracts have previously been shown to be good antibacterial agents, confirming their potential for antibiotic usage. Financial support of this work was provided by the School of Biomolecular and Physical Sciences, Griffith University, Australia.
SQuAD Model Comparison

This project explores and compares different NLP architectures performance on The Stanford Question Answering Data(SQuAD). The basest performances model is BERT based model with addition layer on original BERT SQuAD implementation. This model’s F1 score and Exact Match score is 73.77. But this model takes long time to train each epoch, and does not improve after trained 3 epochs. QANet based model provided slightly lower F1 and EM score, but continuous improving with training.
Chapter 11 Design and Analysis of Tagging Studies

Tagging and marking studies of fish populations are used to examine movement patterns and estimate growth rates, demographic parameters, and abundances. The key steps in conducting an effective tagging study are (1) careful planning to ensure that study objectives are addressed, (2) selecting an appropriate tag or mark, (3) ensuring that sufficient numbers of animals are marked and recaptured to generate parameter estimates of sufficient precision to meet management needs, (4) meeting the sometimes rigorous assumptions required to provide accurate parameter estimates, (5) employing appropriate analytical methods, and (6) interpreting the results properly. This chapter provides guidance on designing simple tagging studies to calculate common fisheries estimates such as abundances, survival rates, components of mortality (fishing and natural), movement patterns, and growth rates. Most tagging and marking studies are similar in that they create a subset of animals from the population that are “known” and identified by their tags or marks. This subset of animals is then followed through space or time (or both) by subsequent recaptures and used to provide information on the entire population. A strength of a well-planned tagging program is that multiple characteristics of interest to researchers and managers, such as movements, growth, and mortality rates, can often be addressed in the same study. Many essential questions must be considered for any tagging study, including the following.
Software coupling between RadThermIR and SE-WORKBENCH

The SE-WORKBENCH workshop, also called CHORALE (“si mulated Optronic Acoustic Radar battlefield”) by th e French MoD/DGA, is used to perform multi-sensors si mulations on complex 3D synthetic environment. RadT hermIR is a full-featured thermal analysis software for advan ce Computer-aided engineering applications. RadTher mIR employs a state-of-the-art radiation module and a user friend ly GUI for simulating multimode heat transfer (radi tion, conduction, and convection) and one-dimensional fluid flow. Rad ThermIR is efficient in the accurate computation of a small scene like a target with an engine whilst SE-WORKBENCH is efficient in the computation of large scene. This article describes the recent coupling of the SE-WORKBENCH w ith RadThermIR. It has been developed in order to i nherit the advantages of the two software. There is a base cou pling and an advance coupling. The base coupling co sists in the bidirectional conversion of the data generated by SEWORKBENCH and by RadThermIR. The advanced coupling consists in an API called SE-TK-RADTHERMIR that pro vides a set of functions in order to use the therma l results computed by RadThermIR in the simulation of infrare d images by the SE-WORKBENCH tools.
Knowledge and practice of cardiopulmonary resuscitation among clinical students of a medical school in Kano, Nigeria

INTRODUCTION: Among common determinants of survival include the ability to effectively execute the basic life support drill during resuscitation. Therefore, this study seeks to determine the knowledge of cardiopulmonary resuscitation (CPR) among medical trainees who are in their clinical years in our tertiary hospital with the aim of identifying knowledge gaps if any. MATERIALS AND METHODS: The study was cross-sectional and was conducted over 12 weeks from April to June 2017. A pretested self-administered questionnaire which was developed in English language was distributed to the subjects. RESULTS: There were 118 male (67.4%) and 57 female (32.6%). Furthermore, 95.4% of the respondents were unaware of circulation, airway and breathing sequence (CAB) in adult resuscitation; and 82.3% were aware of ABC steps in pediatric resuscitation; 52% of the respondents were wrong in adult chest compression to ventilation ratio; similarly, 46.3% were incorrect on pediatric chest compression: ventilation ratio. One hundred and forty-six (83.4%) of the respondents had seen a defibrillator; however, only 3 (2.1%) had ever used it. The knowledge score of the respondents ranged from 0.0 to 55.0; while the mean was 19.4 ± 11.8. One hundred and seventy (97.1%) of the respondents scored <50%. The knowledge score was generally poor for all the classes through this observation was not statistically significant (Fisher's exact test = 1.926, P = 0.449); similarly, the timing of CPR training had no relationship with their knowledge score however this finding was not statistically significant (Fisher's exact test = 3.262,P= 1.00). CONCLUSION: There was poor knowledge of CPR among respondents despite reporting been trained.
Digitization in forensic odontology: A paradigm shift in forensic investigations

Forensic dentistry deals with proper handling, examination, and evaluation of dental records, which are then presented in the interest of law for justice. It plays a major role in identification of deceased individuals who cannot be identified visually or by other means after mass disasters or crimes. Digital forensics has revolutionized the traditional forensic investigations in terms of acquisition, analysis, and reporting of forensic evidence and its application is becoming common in the mass disasters, earthquakes, and terrorism. Sophistication of software and advent of digital technologies such as computers, computer-aided design computer-aided manufacturing systems, digital records, facial reconstruction, touch-free autopsy, and virtopsy has resulted in quick identification and extraction of a large amount of data with reduced sampling bias. This paper focuses on the evolution of forensic dentistry for effective detection and resolution of medico-legal matters and also highlights the use of comparison microscopes and new robotic tools by few forensic laboratories for automation of deoxyribonucleic acid sampling processes for human identification.
Maximizing the Efficiency of Vanillin Production by Biocatalyst Enhancement and Process Optimization

The rising demand of bio-vanillin and the possibility to use microbial biotransformation to produce this compound from agroindustrial byproducts are economically attractive. However, there are still several bottlenecks, including substrate and product toxicity, formation of undesired products and genetic stability of the recombinant strains, that impede an efficient use of recombinant Escherichia coli strains to make the whole process cost effective. To overcome these problems, we developed a new E. coli strain, named FR13, carrying the Pseudomonas genes encoding feruloyl-CoA synthetase and feruloyl-CoA hydratase/aldolase integrated into the chromosome and, using resting cells, we demonstrated that the vanillin yield and selectivity were strongly affected by the physiological state of the cells, the temperature used for the growth and the recovery of the biomass and the composition and pH of the bioconversion buffer. The substrate consumption rate and the vanillin yield increased using a sodium/potassium phosphate buffer at pH 9.0 as bioconversion medium. Optimization of the bioprocess variables, using response surface methodology, together with the use of a two-phase (solid-liquid) system for the controlled release of ferulic acid allowed us to increase the vanillin yield up to 28.10 ± 0.05 mM. These findings showed that recombinant plasmid-free E. coli strains are promising candidates for the production of vanillin at industrial scale and that a reduction of the cost of the bioconversion process requires approaches that minimize the toxicity of both ferulic acid and vanillin.
LFA-1 Controls Th1 and Th17 Motility Behavior in the Inflamed Central Nervous System

Leukocyte trafficking is a key event during autoimmune and inflammatory responses. The subarachnoid space (SAS) and cerebrospinal fluid are major routes for the migration of encephalitogenic T cells into the central nervous system (CNS) during experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis, and are sites of T cell activation before the invasion of CNS parenchyma. In particular, autoreactive Th1 and Th17 cell trafficking and reactivation in the CNS are required for the pathogenesis of EAE. However, the molecular mechanisms controlling T cell dynamics during EAE are unclear. We used two-photon laser microscopy to show that autoreactive Th1 and Th17 cells display distinct motility behavior within the SAS in the spinal cords of mice immunized with the myelin oligodendrocyte glycoprotein peptide MOG35−55. Th1 cells showed a strong directional bias at the disease peak, moving in a straight line and covering long distances, whereas Th17 cells exhibited more constrained motility. The dynamics of both Th1 and Th17 cells were strongly affected by blocking the integrin LFA-1, which interfered with the deformability and biomechanics of Th1 but not Th17 cells. The intrathecal injection of a blocking anti-LFA-1 antibody at the onset of disease significantly inhibited EAE progression and also strongly reduced neuro-inflammation in the immunized mice. Our results show that LFA-1 plays a pivotal role in T cell motility during EAE and suggest that interfering with the molecular mechanisms controlling T cell motility can help to reduce the pathogenic potential of autoreactive lymphocytes.
Community Structure, Abundance and Potential Functions of Bacteria and Archaea in the Sansha Yongle Blue Hole, Xisha, South China Sea

The Sansha Yongle Blue Hole is the deepest blue hole in the world and exhibits unique environmental characteristics. In this paper, Illumina sequencing and qPCR analysis were conducted to obtain the microbial information in this special ecosystem. The results showed that the richness and diversity of bacterial communities in the hole was greater than those of archaeal communities, and bacterial and archaeal communities were dominated by Proteobacteria and Euryarchaeota, respectively. Temperature and nitrate concentration significantly contributed to the heterogeneous distribution of major bacterial clades; salinity explained most variations of the archaeal communities, but not significant. A sudden increase of bacterial 16S rRNA, archaeal 16S rRNA, ANAMMOX 16S rRNA, nirS and dsrB gene was noticed from 90 to 100 m in the hole probably due to more phytoplankton at this depth. Sulfur oxidation and nitrate reduction were the most abundant predicted ecological functions in the hole, while lots of archaea were predicted to be involved in aerobic ammonia oxidation and methanogenesis. The co-occurrence network analysis illustrated that a synergistic effect between sulfate reduction and sulfur oxidation, and between nitrogen fixation and denitrification, a certain degree of coupling between sulfur and nitrogen cycle was also observed in the hole. The comparisons of bacterial and archaeal communities between the hole and other caves in the world (or other areas of the South China Sea) suggest that similar conditions are hypothesized to give rise to similar microbial communities, and environmental conditions may contribute significantly to the bacterial and archaeal communities.
Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells

Non-mammalian vertebrates, including zebrafish, retain the ability to regenerate hair cells (HCs) due to unknown molecular mechanisms that regulate proliferation and conversion of non-sensory supporting cells (nsSCs) to HCs. This regenerative capacity is not conserved in mammals. Identification of uniquely expressed orthologous genes in zebrafish nsSCs may reveal gene candidates involved in the proliferation and transdifferentiation of zebrafish nsSCs to HCs in the inner ear. A list of orthologous protein-coding genes was generated based on an Ensembl Biomart comparison of the zebrafish and mouse genomes. Our previously published RNA-seq-based transcriptome datasets of isolated inner ear zebrafish nsSCs and HCs, and mouse non-sensory supporting pillar and Deiters’ cells, and HCs, were merged to analyze gene expression patterns between the two species. Out of 17,498 total orthologs, 11,752 were expressed in zebrafish nsSCs and over 10,000 orthologs were expressed in mouse pillar and Deiters’ cells. Differentially expressed genes common among the zebrafish nsSCs and mouse pillar and Deiters’ cells, compared to species-specific HCs, included 306 downregulated and 314 upregulated genes; however, over 1,500 genes were uniquely upregulated in zebrafish nsSCs. Functional analysis of genes uniquely expressed in nsSCs identified several transcription factors associated with cell fate determination, cell differentiation and nervous system development, indicating inherent molecular properties of nsSCs that promote self-renewal and transdifferentiation into new HCs. Our study provides a means of characterizing these orthologous genes, involved in proliferation and transdifferentiation of nsSCs to HCs in zebrafish, which may lead to identification of potential targets for HC regeneration in mammals.
Long Non-coding RNAs in Myeloid Malignancies

Acute myeloid leukemia (AML) represents 80% of adult leukemias and 15–20% of childhood leukemias. AML are characterized by the presence of 20% blasts or more in the bone marrow, or defining cytogenetic abnormalities. Laboratory diagnoses of myelodysplastic syndromes (MDS) depend on morphological changes based on dysplasia in peripheral blood and bone marrow, including peripheral blood smears, bone marrow aspirate smears, and bone marrow biopsies. As leukemic cells are not functional, the patient develops anemia, neutropenia, and thrombocytopenia, leading to fatigue, recurrent infections, and hemorrhage. The genetic background and associated mutations in AML blasts determine the clinical course of the disease. Over the last decade, non-coding RNAs transcripts that do not codify for proteins but play a role in regulation of functions have been shown to have multiple applications in the diagnosis, prognosis and therapeutic approach of various types of cancers, including myeloid malignancies. After a comprehensive review of current literature, we found reports of multiple long non-coding RNAs (lncRNAs) that can differentiate between AML types and how their exogenous modulation can dramatically change the behavior of AML cells. These lncRNAs include: H19, LINC00877, RP11-84C10, CRINDE, RP11848P1.3, ZNF667-AS1, AC111000.4-202, SFMBT2, LINC02082-201, MEG3, AC009495.2, PVT1, HOTTIP, SNHG5, and CCAT1. In addition, by performing an analysis on available AML data in The Cancer Genome Atlas (TCGA), we found 10 lncRNAs with significantly differential expression between patients in favorable, intermediate/normal, or poor cytogenetic risk categories. These are: DANCR, PRDM16-DT, SNHG6, OIP5-AS1, SNHG16, JPX, FTX, KCNQ1OT1, TP73-AS1, and GAS5. The identification of a molecular signature based on lncRNAs has the potential for have deep clinical significance, as it could potentially help better define the evolution from low-grade MDS to high-grade MDS to AML, changing the course of therapy. This would allow clinicians to provide a more personalized, patient-tailored therapeutic approach, moving from transfusion-based therapy, as is the case for low-grade MDS, to the introduction of azacytidine-based chemotherapy or allogeneic stem cell transplantation, which is the current treatment for high-grade MDS.
Relation Between Working Memory Capacity of Biological Movements and Fluid Intelligence

Studies have revealed that there is an independent buffer for holding biological movements (BM) in working memory (WM), and this BM-WM has a unique link to our social ability. However, it remains unknown as to whether the BM-WM also correlates to our cognitive abilities, such as fluid intelligence (Gf). Since BM processing has been considered as a hallmark of social cognition, which distinguishes from canonical cognitive abilities in many ways, it has been hypothesized that only canonical object-WM (e.g., memorizing color patches), but not BM-WM, emerges to have an intimate relation with Gf. We tested this prediction by measuring the relationship between WM capacity of BM and Gf. With two Gf measurements, we consistently found moderate correlations between BM-WM capacity, the score of both Raven’s advanced progressive matrix (RAPM), and the Cattell culture fair intelligence test (CCFIT). This result revealed, for the first time, a close relation between WM and Gf with a social stimulus, and challenged the double-dissociation hypothesis for distinct functions of different WM buffers.
Argentina: assessing changes in targeting health and nutrition policies

This study assesses the level of targeting achieved in health and nutrition policies directed to pregnant women and children under 5 years of age in Argentina. It is based on information from two large household data sets collected through Living Standards Measurement Surveys undertaken in 1997 and 2001. The results suggest that although health and nutrition public programs are pro-poor, they became less so between 1997 and 2001 for two reasons: a substantial reduction in the fertility rate of poor couples, and an increase in the use of public facilities by wealthier households, likely triggered by the economic crisis that Argentina has suffered since 1998.