Miracle-dz/UniFAR-FTUs huggingface dataset:
Energy-Reliability Aware Link Optimization for Battery-Powered IoT Devices With Nonideal Power Amplifiers

In this paper, we study cross-layer optimization of low-power wireless links for reliability-aware applications while considering both the constraints and the nonideal characteristics of the hardware in Internet-of-Things (IoT) devices. Specifically, we define an energy consumption (EC) model that captures the energy cost—of transceiver circuitry, power amplifier (PA), packet error statistics, packet overhead, etc.—in delivering a useful data bit. We derive the EC models for an ideal and two realistic nonlinear PA models. To incorporate packet error statistics, we develop a simple, in the form of elementary functions, and accurate closed-form packet error rate approximation in Rayleigh block-fading. Using the EC models, we derive energy-optimal yet reliability and hardware compliant conditions for limiting unconstrained optimal signal-to-noise ratio (SNR), and payload size. Together with these conditions, we develop a semi-analytic algorithm for resource-constrained IoT devices to jointly optimize parameters on physical (modulation size, SNR) and medium access control (payload size and the number of retransmissions) layers in relation to link distance. Our results show that despite reliability constraints, the common notion—higher-order ${M}$ -ary modulations are energy optimal for short-range communication—prevails, and can provide up to 180% lifetime extension as compared to often used OQPSK modulation in IoT devices. However, the reliability constraints reduce both their range and the energy efficiency, while nonideal traditional PA reduces the range further by 50% and diminishes the energy gains unless a better PA is used.
Detecting Forwarding Misbehavior In Clustered IoT Networks

Internet of Things (IoT) devices in clustered wireless networks can be compromised by compromising the gateway which they are associated with. In such scenarios, an adversary who has compromised the gateway can affect the network's performance by deliberately dropping the packets transmitted by the IoT devices. In this way, the adversary can actually mimic a bad radio channel. Hence, the affected IoT device has to retransmit the packet which will drain its battery at a faster rate. To detect such an attack, we propose a centralized detection system in this paper. It uses the uplink packet drop probability of the IoT devices to monitor the behavior of the gateway with which they are associated. The detection rule proposed is given by the generalized likelihood ratio test, where the attack probabilities are estimated using maximum likelihood estimation. Results presented show the effectiveness of the proposed detection mechanism and also demonstrate the impact of the choice of system parameters on the detection algorithm.
İSTANBUL MENKUL KIYMETLER BORSASI’NDA EŞHAREKETLİLİK VE ASİMETRİK AYARLAMA

Bu makale, Istanbul Menkul Kiymetler Borsasi’na (IMKB) ait farkli sektor endeksleri arasindaki simetrik ve asimetrik estumlesme iliskilerini incelemektedir. Calismaya konu olan endeksler ISE100, sanayi, mali, hizmetler ve teknolojidir. Bu calismayi yapmak icin Engle Granger estumlesme ile Ender ve Siklos (2001) esikli kendiyle baglasimli (EKB) ve moment-esikli kendiyle baglasimli (M-EKB) yontemleri kullanilmistir. Makalenin temel bulgusu sektor endeksleri arasinda kisa ve uzun donemli istatistiksel bagintinin olmadigidir. Bu sonuc IMKB’nda sektor endeksleri arasinda portfoy cesitlendirmesinin getiri saglayabilecegini gostermektedir
Photographs of real human figures: Item types and persistent sex differences in mental rotation

The goal of the current study was to provide a better understanding of the role of image familiarity, embodied cognition, and cognitive strategies on sex differences in performance when rotating blocks and photographs of real human bodies. Two new Mental Rotation Tests (MRTs) were created: one using photographs of real human models positioned as closely as possible to computer drawn figures from the human figures MRT used in Doyle and Voyer’s 2013 study, and one using analogous block figures. It was hypothesised that, when compared to the analogous block figures, the real human figures would lead to improved accuracy among both men and women, a reduced magnitude of sex differences in accuracy, and a reduced effect of occlusion on women’s performance when compared to analogous block figures. The three-way interaction between test, sex, and occlusion reported in Doyle and Voyer’s 2013 study was not replicated in the current study. However, women’s scores on the real human figures improved significantly more than men’s scores on the real human figures test compared to gender differences in improvement on the block figures test. This finding points to a greater strategy shift among women than men when rotating human figures.
Effects of the Safety Squat Bar on Trunk and Lower-Body Mechanics During a Back Squat.

Hecker, KA, Carlson, LA, and Lawrence, MA. Effects of the safety squat bar on trunk and lower-body mechanics during a back squat. J Strength Cond Res XX(X): 000-000, 2018-The purpose of this study was to determine whether the safety squat bar (SSB) alters the mechanics and muscle activity of a back squat compared with a standard barbell (ST). Motion and muscle activation of the trunk and lower extremity were measured while 12 competitive powerlifters (8 males, 4 females, age 31.5 ± 6.3 years, body mass 88.1 ± 20.7 kg, competitive lifting experience 3.3 ± 2.8 years) squatted 3 sets of 5 repetitions at 75% of their 3 repetition maximum (3RM). Mean muscle activity and peak joint flexion angles were measured for the trunk and one lower extremity. A repeated-measures analysis of variance (p = 0.05) revealed an 11.3% decrease in 3RM when using the SSB. When using the SSB, there was a decrease in trunk and hip flexion (7.3 and 5.7° respectively) and a 50.3% increase in lower trapezius activation. However, using the SSB decreased activation of the rectus abdominis (46.3%), medial hamstring (17.1%), lateral hamstring (15.1%), vastus lateralis (9.3%), and medial gastrocnemius (18.8%). Squatting with the SSB resulted in a more upright trunk angle, which places less stress on the lower back, a commonly injured area when squatting. Decreases in lower-extremity muscle activation are likely due to the decreased load used, suggesting that the SSB may not be as effective as a standard bar to increase lower-extremity strength. However, the increase in the lower trapezius with the lighter load suggests that midback musculature may be challenged more by the SSB than a standard barbell.
Basal Forebrain Mediates Motivational Recruitment of Attention by Reward-Associated Cues

The basal forebrain, composed of distributed nuclei, including substantia innominata (SI), nucleus basalis and nucleus of the diagonal band of Broca plays a crucial neuromodulatory role in the brain. In particular, its projections to the prefrontal cortex have been shown to be important in a wide variety of brain processes and functions, including attention, learning and memory, arousal, and decision-making. In the present study, we asked whether the basal forebrain is involved in recruitment of cognitive effort in response to reward-related cues. This interaction between motivation and cognition is critically impacted in psychiatric conditions such as schizophrenia. Using the Designer Receptor Exclusively Activated by Designer Drug (DREADD) technique combined with our recently developed signaled probability sustained attention task (SPSA), which explicitly assays the interaction between motivation and attention, we sought to determine the role of the basal forebrain in this interaction. Rats were stereotaxically injected in the basal forebrain with either hM4D(Gi) (a virus that expresses receptors which silence neurons in the presence of the drug clozapine-N-oxide; CNO) or a control virus and tested in the SPSA. Behavior of rats during baseline and under saline indicated control by reward probability. In the presence of CNO, differential accuracy of hM4D(Gi) rats on high and low reward-probability trials was abolished. This result occurred despite spared ability of the reward-probability signals to differentially impact choice-response latencies and omissions. These results indicate that the basal forebrain is critical for the motivational recruitment of attention in response to reward-related cues and are consistent with a role for basal forebrain in encoding and transmitting motivational salience of reward-related cues and readying prefrontal circuits for further attentional processing.
Visualizing the Role of 2’-OH rRNA Methylations in the Human Ribosome Structure

Chemical modifications of RNA have recently gained new attention in biological sciences. They occur notably on messenger RNA (mRNA) and ribosomal RNA (rRNA) and are important for various cellular functions, but their molecular mechanism of action is yet to be understood in detail. Ribosomes are large ribonucleoprotein assemblies, which synthesize proteins in all organisms. Human ribosomes, for example, carry more than 200 modified nucleotides, which are introduced during biogenesis. Chemically modified nucleotides may appear to be only scarcely different from canonical nucleotides, but modifications such as methylations can in fact modulate their chemical and topological properties in the RNA and alter or modulate the overall translation efficiency of the ribosomes resulting in dysfunction of the translation machinery. Recent functional analysis and high-resolution ribosome structures have revealed a large repertoire of modification sites comprising different modification types. In this review, we focus on 2′-O-methylations (2′-O-Me) and discuss the structural insights gained through our recent cryo electron microscopy (cryo-EM) high-resolution structural analysis of the human ribosome, such as their locations and their influence on the secondary and tertiary structures of human rRNAs. The detailed analysis presented here reveals that ribose conformations of the rRNA backbone differ when the 2′-OH hydroxyl position is methylated, with 3′-endo conformations being the default and the 2′-endo conformations being characteristic in that the associated base is flipped-out. We compare currently known 2′-O-Me sites in human rRNAs evaluated using RiboMethSeq and cryo-EM structural analysis and discuss their involvement in several human diseases.
Design and implementation of structural bioinformatics projects for biological sciences undergraduate students

Contemporary biology is currently undergoing a revolution, driven by the availability of high‐throughput technologies and a wide variety of bioinformatics tools. However, bioinformatics education and practice is still in its infancy in most of the African continent. Consequently, concerted efforts have been made in recent years to incorporate bioinformatics modules into biological sciences curriculum of African Universities. Despite this, one aspect of bioinformatics that is yet to be incorporated is structural bioinformatics. In this article, we report on a structural bioinformatics project carried out by final year project students in a Nigerian university. The target protein was the thermoacidophilic Sulfolobus islandicus rod‐shaped virus 1 (SIRV1) Rep protein, which was further characterized using various free, user‐friendly and online sequence‐based and structure‐based bioinformatics tools. This exercise gave students the opportunity to generate new data, interpret the data, and acquire collaborative research skills. In this report, emphasis is placed on analysis of the data generated to further encourage analytical skills. By sharing this experience, it is anticipated that other similar institutions would adopt parallel strategies to expose undergraduate students to structural biology, and increase awareness of freely available bioinformatics tools for tackling pertinent biological questions. © 2018 International Union of Biochemistry and Molecular Biology, 46(5):547–554, 2018.
Brain Computer Interface Using Modulation of Auditory Steady-State Response with Help of Stochastic Resonance*

This paper proposes an eye-movement independent brain computer interface based on the modulations of auditory steady-state response (ASSR-BCI) to amplitude-modulated (AM) tones elicited by paying selective attention to one of the two AM tones. Moreover, the proposed ASSR-BCI exploits a stochastic resonance effect to improve the signal separation and attained the mean classification accuracy of 77 % across nine normal subjects under a noise-added condition with sound pressures 60 dB for the two tones and 30 dB for the noise added to the two AM tones. Results from information transfer rate and its inter-individual difference suggest that it may be adequate to set an inter-trial interval at 2∽3 s for a trial time length. It is consequently feasible to develop a practical eye-movement-independent BCI available in eyes-closed state by optimizing the parameters such as the trial time length and electrode sites each user.
STEAMing the Ships for the Great Voyage: Design and Evaluation of a Technology integrated Maker Game

This study presents an interdisciplinary learning model that puts students in a historical context, in which they have to apply their knowledge of history, geography, math, physics, mechanics and natural sciences to achieve the goal of the game. In the learning scenario, students’ critical thinking, creative thinking, computational thinking, and problem-solving abilities, as well as cooperative and competitive gaming strategies are used and enhanced. From the research results, it is evident that the “Maker Game for Great Voyage” has succeeded in the instructional design of technology-integrated game-based learning with STEAM and maker, and with the rich historical context of the Age of Discovery. Also, from pre-test and post-test evaluations and questionnaires, this research looks into students’ learning effectiveness; and through qualitative research methods, students’ group cooperative styles and competitive gaming strategies are analyzed in terms of students’ personality traits.
Power Bounds and Energy Efficiency in Incremental  $\Delta\Sigma$  Analog-to-Digital Converters

Incremental analog-to-digital-converters (IADCs) are variants of <inline-formula> <tex-math notation="LaTeX">$\triangle \Sigma $ </tex-math></inline-formula> ADCs, which have been increasingly used for low-power sensory applications in recent years. Most IADC applications require high resolution and high energy efficiency. In this paper, we present a systematic analysis of IADCs. We derive analytical design equations for practical IADC designs. Process limitations are included in the model as well. The equations are verified with a 14-bit second-order IADC design in a 0.18-<inline-formula> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula> process. With the design equations, the theoretical energy efficiency bound is derived for IADCs. The efficiency bound is compared with previously reported IADC designs. It is found that the derived bound matches existing designs well.
Functional MRI Investigation of Audiovisual Interactions in Auditory Midbrain*

The brain integrates information from different sensory modalities to form a representation of the environment and facilitate behavioral responses. The auditory midbrain or inferior colliculus (IC) is a pivotal station in the auditory system, integrating ascending and descending information from various auditory sources and cortical systems. The present study investigated the modulation of auditory responses in the IC by visual stimuli of different frequencies and intensities in rats using functional MRI (fMRI). Low-frequency (1 Hz) high-intensity visual stimulus suppressed IC auditory responses. However, high-frequency (10 Hz) or low-intensity visual stimuli did not alter the IC auditory responses. This finding demonstrates that cross-modal processing occurs in the IC in a manner that depends on the stimulus. Furthermore, only low-frequency high-intensity visual stimulus elicited responses in non-visual cortical regions, suggesting that the above cross-modal modulation effect may arise from top-down cortical feedback. These fMRI results provide insight to guide future studies of cross-modal processing in sensory pathways.
Obstructive sleep apnea in patients surviving acute hypercapnic respiratory failure is best predicted by static hyperinflation

Rationale Acute hypercapnic respiratory failure (AHRF) treated with non-invasive ventilation in the ICU is frequently caused by chronic obstructive pulmonary disease (COPD) exacerbations and obesity-hypoventilation syndrome, the latter being most often associated with obstructive sleep apnea. Overlap syndrome (a combination of COPD and obstructive sleep apnea) may represent a major burden in this population, and specific diagnostic pathways are needed to improve its detection early after ICU discharge. Objectives To evaluate whether pulmonary function tests can identify a high probability of obstructive sleep apnea in AHRF survivors and outperform common screening questionnaires to identify the disorder. Methods Fifty-three patients surviving AHRF (31 males; median age 67 years (interquartile range: 62–74) participated in the study. Anthropometric data were recorded and body plethysmography was performed 15 days after ICU discharge. A sleep study was performed 3 months after ICU discharge. Results The apnea-hypopnea index was negatively associated with static hyperinflation as measured by the residual volume to total lung capacity ratio in the % of predicted (coefficient = -0.64; standard error 0.17; 95% CI -0.97 to -0.31; p<0.001). A similar association was observed in COPD patients only: coefficient = -0.65; standard error 0.19; 95% CI -1.03 to -0.26; p = 0.002. Multivariate analysis with penalized maximum likelihood confirmed that the residual volume to total lung capacity ratio was the main contributor for apnea-hypopnea index variance in addition to classic predictors. Screening questionnaires to select patients at risk for sleep-disordered breathing did not perform well. Conclusions In AHRF survivors, static hyperinflation is negatively associated with the apnea-hypopnea index in both COPD and non-COPD patients. Measuring static hyperinflation in addition to classic predictors may help to increase the recognition of obstructive sleep apnea as common screening tools are of limited value in this specific population.
Cancer‐associated fibroblasts (CAFs) promote the lymph node metastasis of esophageal squamous cell carcinoma

Lymph node metastasis is a pathognomonic feature of spreading tumors, and overcoming metastasis is a challenge in attaining more favorable clinical outcomes. Esophageal cancer is an aggressive tumor for which lymph node metastasis is a strong poor prognostic factor, and the tumor microenvironment (TME), and cancer‐associated fibroblasts (CAFs) in particular, has been implicated in esophageal cancer progression. CAFs play a central role in the TME and have been reported to provide suitable conditions for the progression of esophageal cancer, similar to their role in other malignancies. However, little is known concerning the relevance of CAFs to the lymph node metastasis of esophageal cancer. Here, we used clinical samples of esophageal cancer to reveal that CAFs promote lymph node metastasis and subsequently verified the intercellular relationships in vitro and in vivo using an orthotopic metastatic mouse model. In the analysis of clinical samples, FAP+ CAFs were strongly associated with lymph node metastasis rather than with other prognostic factors. Furthermore, CAFs affected the ability of esophageal cancer cells to acquire metastatic phenotypes in vitro; this finding was confirmed by data from an in vivo orthotopic metastatic mouse model showing that the number of lymph node metastases increased upon injection of cocultured cancer cells and CAFs. In summary, we verified in vitro and in vivo that the accumulation of CAFs enhances the lymph node metastasis of ESCC. Our data suggest that CAF targeted therapy can reduce lymph node metastasis and improve the prognosis of patients with esophageal cancer in the future.
Culprit Plaque Characteristics in Patients With Sleep‐Disordered Breathing Undergoing Percutaneous Coronary Intervention: An Intravascular Ultrasound Study

Background Sleep‐disordered breathing (SDB) is a novel cardiovascular risk factor. However, the coronary plaque characteristics of patients with SDB with coronary artery disease are still unclear. Methods and Results This study included 289 consecutive patients with coronary artery disease undergoing percutaneous coronary intervention. Plaque characteristics of the culprit lesion were assessed by preintervention intravascular ultrasound. The presence of SDB was defined as a 3% oxygen desaturation index of ≥15 events per hour measured by nocturnal pulse oximetry. Of 289 patients, the median 3% oxygen desaturation index was 9.6 (interquartile range, 5.1–16.6), and 88 patients (30.4%) were defined as having SDB. Compared with the no‐SDB group, the SDB group had a larger total atheroma volume of the culprit lesion (224.5 mm3 versus 190.8 mm3, P=0.05). The median maximum attenuation and calcification angle were 140° and 130°, respectively. Attenuated plaque with a maximum attenuation angle >140° was more frequently observed in the SDB group compared with the no‐SDB group (34.9% versus 22.6%; P=0.03). However, there were no statistically significant differences between groups in the maximum calcium angle and the frequency of calcific plaques with a maximum calcium angle >130°. Multivariable logistic regression analysis showed that the presence of SDB was a significant predictor of a greater ultrasound attenuation angle (>140°) (odds ratio, 1.86; 95% confidence interval, 1.02–3.39; P=0.04). Conclusions SDB was associated with larger atheroma plaque volume and a greater ultrasound attenuation, which are discriminators of plaque vulnerability. Further studies are needed to clarify the effects of SDB treatment on coronary plaque lesions.
The Two Isoforms of Lyn Display Different Intramolecular Fuzzy Complexes with the SH3 Domain

The function of the intrinsically disordered Unique domain of the Src family of tyrosine kinases (SFK), where the largest differences between family members are concentrated, remains poorly understood. Recent studies in c-Src have demonstrated that the Unique region forms transient interactions, described as an intramolecular fuzzy complex, with the SH3 domain and suggested that similar complexes could be formed by other SFKs. Src and Lyn are members of a distinct subfamily of SFKs. Lyn is a key player in the immunologic response and exists in two isoforms originating from alternative splicing in the Unique domain. We have used NMR to compare the intramolecular interactions in the two isoforms and found that the alternatively spliced segment interacts specifically with the so-called RT-loop in the SH3 domain and that this interaction is abolished when a polyproline ligand binds to the SH3 domain. These results support the generality of the fuzzy complex formation in distinct subfamilies of SFKs and its physiological role, as the naturally occurring alternative splicing modulates the interactions in this complex.