Miracle-dz/UniFAR-FTUs huggingface dataset:
Automatic Sagittal Plane Detection for the Identification of the Mandibular Canal

Identification of the mandibular canal path in Computed Tomography (CT) scans is important in dental implantology. Typically, prior to the implant planning, dentists find a sagittal plane where the mandibular canal path is maximally observed, to manually identify the mandibular canal. However, this is time-consuming and requires extensive experience. In this paper, we propose a deep-learning-based framework to detect the desired sagittal plane automatically. This is accomplished by utilizing two main techniques: 1) a modified version of the iterative transformation network (ITN) method for obtaining initial planes, and 2) a fine searching method based on a convolutional neural network (CNN) classifier for detecting the desirable sagittal plane. This combination of techniques facilitates accurate plane detection, which is a limitation of the stand-alone ITN method. We have tested on a number of CT datasets to demonstrate that the proposed method can achieve more satisfactory results compared to the ITN method. This allows dentists to identify the mandibular canal path efficiently, providing a foundation for future research into more efficient, automatic mandibular canal detection methods.
Finite Element Simulation of Fatigue Life Estimation and Crack Path Prediction of Two-dimensional Structures Components

The main objective of this work is to analyse fatigue crack propagation of two-dimensional structures under constant amplitude loading using the developed adaptive mesh finite element. The finite element mesh is generated using the advancing front method. The adaptive remeshing process is carried out based on the posteriori stress error norm scheme. The stress intensity factors are estimated by employing the displacement extrapolation technique facilitated by construction of singular crack tip elements. The crack propagation is modelled by the splitting node approach and the trajectory follows the successive linear extensions of each crack increment. The propagation process is driven by linear elastic fracture mechanics approach. In the analysis, the resulted stress intensity factor range at each of crack increments is recorded. Fatigue life cycle can be predicted immediately after completion of the recording by integrating the generalized Paris’ equation. The procedure is applied to the fatigue analysis of three different specimens namely modified compact tension, two internal non-colinear cracks specimen and PMMA beams specimen. Verification of the predicted fatigue life is conducted by comparing the results with the relevant experimental data and numerical results obtained by other researchers. The comparisons show that the developed programme is highly reliable in simulating fatigue crack propagation and predicting the fatigue life cycles.
Sjögren ’ s syndrome , xerostomia , cholinergic agent , electrostimulation , acupuncture , saliva substitutes

Article Interventions for dry mouth and hyposalivation in Sjögren’s syndrome: a systematic review and meta-analysis. Abstract Objectives Systematic review with meta-analysis of interventions for dry mouth symptoms and hyposalivation of Sjögren’s syndrome (SS). function was assessed shortly after administration of the intervention in four studies, after 60 minutes in four studies and after 90 minutes in one study, therefore indicating the short-term effects of the interventions. Three studies assessed salivary flow one or more weeks after the last administration of the experimental treatment, hence reporting on long-term effects. The timing of salivary flow measurement was unclear in twenty studies. of a short-term minutes) in the global dry mouth evaluation (on a 3-point Likert in the of VAS score (dry mouth) between the cevimeline group and placebo. a significantly higher short-term change in salivary flow in the cevimeline group compared to placebo vs 0.015 mL/min (mean change); P<0.05)], a effects clinical at unclear risk of allocation concealment. et al. in a cross-over trial with low risk of use of cevimeline for change in xerostomia (Xerostomia Inventory), salivary flow or QoL (GOHAI, SF-36) between the intervention and placebo group (Leung et al., in within-group separate analysis baseline, be p<0.0001] between the group taking one tablet of pilocarpine vs placebo. Two studies using the first generation electrostimulating device vs sham stimulation with no heterogeneity (I 2 =0%) and a total of pooled 100 participants showed a mean difference in short-term unstimulated salivary flow change between groups of 0.17mL/min [95% CI 0.11-0.23; p<0.00001]. Three homogeneous studies (I 2 =9) with a total of 283 participants showed a mean difference in long-term unstimulated salivary flow change of 0.04mL/min between the rituximab and placebo arm [95% CI 0.01-0.06; p=0.002]. Three homogeneous studies (I 2 =35) with a total of 553 participants taking interferon- α showed a mean difference in short-term unstimulated salivary flow change of 0.01mL/min [95% CI 0.01-0.02; p<0.00001] with respect to placebo.
Isomaltulose Synthase ( Pal I) of Klebsiella sp. LX3 CRYSTAL STRUCTURE AND IMPLICATION OF MECHANISM*

Isomaltulose synthase from Klebsiella sp. LX3 ( Pal I, EC 5.4.99.11) catalyzes the isomerization of sucrose to produce isomaltulose ( (cid:1) - D -glucosylpyranosyl-1,6- D fructofuranose) and trehalulose ( (cid:1) - D -glucosylpyranosyl-1,1- D -fructofuranose). The Pal I structure, solved at 2.2-Å resolution with an R -factor of 19.4% and R free of 24.2%, consists of three domains: an N-terminal catalytic ( (cid:2) / (cid:1) ) 8 domain, a subdomain between N (cid:2) 3 and N (cid:1) 3, and a C-terminal domain having seven (cid:2) -strands. The active site architecture of Pal I is identical to that of other glycoside hydrolase family 13 members, suggesting a similar mechanism in substrate binding and hydrolysis. How-ever, a unique RLDRD motif in the proximity of the active site has been identified and shown biochemically to be responsible for sucrose isomerization. A two-step
Drag Analysis from PIV Data in Speed Sports

Aerodynamic drag is computed from velocity measurements obtained with particle image velocimetry (PIV). This allows determining the drag force in combination with the visualization of the flow structures responsible for drag generation. Two experiments are conducted to illustrate the working principle of the approach, which is meant for applications in speed sports. The first experiment assesses the aerodynamic effect of surface roughness by measuring the flow over a circular cylinder dressed in a rough fabric used in professional cycling. The application of roughness can reduce the drag by about 30% with respect to a smooth surface. The second experiment demonstrates at small scale a possible approach to directly study the aerodynamic drag associated to moving athletes. This offers an alternative to the measurements in wind tunnels, where only stationary cases are practically studied. A system towing a sphere of 16 cm diameter is used to demonstrate the concept. Drag coefficient calculations come to agree with literature data within 15%.
REALISATION OF UNIVERSITY-INDUSTRY COLLABORATION THROUGH INDUSTRY-BASED LEARNING AT INDONESIAN HIGHER EDUCATION

The collaboration between universities and industries has become increasingly important for the development of Science and Technology. This types of partnerships are more prominent in the Science Technology Engineering and Mathematics (STEM) disciplines. Literature suggests that the key element of University-Industry Partnership (UIP) is the exchange of knowledge and experience that is mutually beneficial for both parties. An example of how the collaborations manifests in Higher Education is Industry-Based Learning (IBL) where university students are coming into industries to experience and learn how the skills and knowledge acquired in the classroom are implemented in everyday work places. This paper investigate how the University-Industry Collaboration program is implemented though Industry-Based Learning (IBL) at Indonesian Universities and the impact this may have on the university undergraduate students in Indonesia. The research findings offer useful insights and create new knowledge in the field of collaborative education and learning. The research contributes to existing knowledge by providing empirical understanding of the topic as applied to the Indonesian context. The outcomes can be used to improve the quality of University-Industry Partnership programs at Indonesian Universities and inform Indonesian higher education authorities and their industrial partners of an alternative approach to enhance IBL programs.
Design and manufacture of TNT explosives detector sensors based on CNTFET

Purpose Miniaturized smart sensors that can perform sensitive and selective real-time monitoring of target analytes are tremendously valuable for various sensing applications. So, the purpose of this paper is to provide details of sensors based on selective nanocoatings by combining trinitrotoluene (TNT) receptors bound to conjugated polydiacetylene (PDA) polymers with single-walled carbon nanotube field-effect transistors (CNTFETs) for detecting explosives TNT. Design/methodology/approach Following an introduction, this paper describes the way of creating an FET with CNTs, which are functionalized by the peptide based on TNT molecule recognition elements and PDA, to offer a system which has the capability of answering the presence of related target molecules (TNT). Finally, brief conclusions are drawn. Findings Single-wall nanotubes and reduced graphene oxide are interesting materials for creating biosensors of FETs at nanoscale because of unique electrical, mechanical, geometrical and biocompatible properties. Therefore, this sensor is designed and manufactured, and the results of applying TNT to sensor show good sensitivity and selectivity response. Originality/value In this timeframe of history, sensors based on CNTFET are required for different uses, including clinical diagnosis technologies, environmental tests and bioterrorism recognition technologies, that correspond to the military conflicts and terrorism. So, CNTFET sensor design provides real-time detection of TNT explosives.
A new decade for social changes

Tourism industry has become one of the principal sources of economic growth and a viable platform of employment both in Africa and globally. Considering that economic growth and job creation are the focal points of sustainable development goals (SDGs), this study is focused on investigating the relationship they have with tourism in Nigeria. A gross domestic product (GDP) time series dataset is utilized to represent economic growth variable while, statistical data obtained from the WTTC is employed to denote Tourism revenues and arrivals in Nigeria. The study employed Autoregressive Distributed Lag (ARDL) bounds test of cointegration, the Error Correction model and Granger causality tests to empirically examine the impacts tourism has on economic growth and employment in the LACKET states of Nigeria for the period between 1999 to 2019. Generally, the investigations indicate that both in the short and long - run, tourism is positively related to economic growth and employment rate in Nigeria. However, regarding short -run relationship, a lower positive link of tourism revenue is recorded.
A reproducible and accurate 14-drug microtitre plate containing bedaquiline and delamanid for susceptibility testing of Mycobacterium tuberculosis

Universal access testing key TB. UKMYC5 is a 96-well microtitre plate designed by the Comprehensive Resistance Prediction for Tuberculosis: an International Consortium (CRyPTIC) which has the potential to determine, at low cost, the MICs for 14 different anti-TB drugs, including several new and repurposed compounds. It is a dry-format plate and therefore easy to transport and store. UKMYC5 plates were tested by seven laboratories on four continents using a panel of 19 external quality assessment (EQA) strains, including H37Rv. MICs were measured from each plate by two readers using three methods (mirrored-box, microscope and Vizion™ Digital viewing system) at four different timepoints. All EQA strains were whole-genome sequenced and phenotypically characterized by MGIT960, 7H10/7H11 agar and resazurin microtitre assay. The optimum incubation period for a plate is 14 days. The within- and between-laboratory reproducibilities for the best performing methods (mirrored-box and Vizion) were >95% and >92%, respectively. One site was identified as requiring re-training and one drug ( para -aminosalicylic acid) produced inconsistent results. MICs measured using the UKMYC5 microtitre plate (i) are reproducible, (ii) compare well with the results of several established methods and (iii) correlate with the presence or absence of genetic mutations that confer resistance. This study provides evidence that this assay can be deployed by TB reference laboratories world-wide as a diagnostic and research tool.
1 Effect of the Nitrogen Source on the Hydrogen Production Metabolism and 1 hydrogenases of Clostridium butyricum CWBI1009 2

Investigations were carried out to determine the effect of various concentrations 13 of organic and ammonium nitrogen sources on fermentative hydrogen 14 production by the strain Clostridium butyricum CWBI1009. The results 15 indicated that the H 2 -producing metabolism of the strain is favoured within the 16 range (0.56-0.062 g N /L) of peptone and (NH 4 ) 2 SO 4 . Optimal overall 17 performance ( i.e. 1.43 ±0.08 mol H 2 /mol glucose and 1.08 ±0.03 mL H2 /h, 18 respectively) was achieved with 0.062 g N /L of casein peptone. The study of the 19 amino acid uptake and the gene expression pattern for four [FeFe]-hydrogenases 20 and the nitrogenase showed that nitrogen was in excess in all the experiments with a nitrogen concentration above 0.062 g N /L and, at that optimal 22 concentration, the expression of the HydB2 gene would be responsible for the 23 much higher H 2 yield. 24
Mathematica Bohemica

The paper presents the results of numerical solution of the Allen-Cahn equation with a non-local term. This equation originally mentioned by Rubinstein and Sternberg in 1992 is related to the mean-curvature flow with the constraint of constant volume enclosed by the evolving curve. We study this motion approximately by the mentioned PDE, generalize the problem by including anisotropy and discuss the computational results obtained.
A high power and high efficiency GaAs BPLDD SAGFET with WSi/W double-layer gate for mobile communication systems

A buried p-layer LDD (BPLDD) self-aligned gate FET (SAGFET) with a WSi/W double-layer gate for high power amplifiers operating at low voltage supply has been successfully developed. This FET has delivered the high breakdown voltage due to the offset gate structure and the n'- layer separation from the gate edge by sidewall assisted ion-implantation technology. A WSi/W double layer gate structure was employed to reduce the gate resistance. The 1 /spl mu/m gate-length, 1.2 mm gate-width FET exhibited an output power of 24.7 dBm, a power-added efficiency of 54%, and an adjacent channel leakage power of less than -55 dBc at a 1 dB compression power of 22 dBm under a drain bias of 3.3 V at 1.9 GHz.
Positron emission tomography with [F]fluorodeoxyglucose to evaluate neutrophil kinetics during acute lung injury

Chen, Delphine L. , and Daniel P. Schuster. Positron emission tomography with [F]fluorodeoxyglucose to evaluate neutrophil kinetics during acute lung injury. Am J Physiol Lung Cell Mol Physiol 286: L834–L840, 2004. First published December 5, 2003; 10.1152/ ajplung.00339. 2003. —We measured neutrophil glucose uptake with positron emission tomographic imaging and [F]fluorodeoxyglucose ([F]FDG-PET) in anesthetized dogs after intravenous oleic acidinduced acute lung injury (ALI; OA group, n 6) or after low-dose intravenous endotoxin (known to activate neutrophils without causing lung injury) followed by OA (Etx OA group, n 7). The following two other groups were studied as controls: one that received no intervention (n 5) and a group treated with Etx only (n 6). PET imaging was performed 1.5 h after initiating experimental interventions. The rate of [H]deoxyglucose ([H]DG) uptake was also measured in vitro in cells recovered from bronchoalveolar lavage (BAL) performed after PET imaging. Circulating neutrophil counts fell significantly in animals treated with Etx but not in the other two groups. The rate of [F]FDG uptake, measured by the influx constant Ki, was significantly elevated (P 0.05) in both Etx-treated groups (7.9 2.6 10 3 ml blood ml lung 1 min 1 in the Etx group, 9.3 4.8 10 3 ml blood ml lung 1 min 1 in the Etx OA group) but not in the group treated only with OA (3.4 0.8 10 3 ml blood ml lung 1 min ) when compared with the normal control (1.6 0.4 10 3 ml blood ml lung 1 min ). [H]DG uptake was increased (73 7%) in BAL neutrophils recovered from the Etx OA group (P 0.05) but not in the OA group. Ki and [H]DG uptake rates were linearly correlated (R 0.65). We conclude that the rate of [F]FDG uptake in the lungs during ALI reflects the state of neutrophil activation. [F]FDG-PET imaging can detect pulmonary sequestration of activated neutrophils, despite the absence of alveolar neutrophilia. Thus [F]FDG-PET imaging may be a useful tool to study neutrophil kinetics during ALI.
Challenges in remaining " UpToDate": A case study identifying errors in evidence-based point-of-care resources

: Our understanding of the prevalence of mental health disorders (MHDs) in society is in the midst of a paradigm shift: where MHDs were once considered rare within a population, studies through the last decade have converged to the conclusion that they are, in fact, near universal. Consequently, the demand for mental health treatment has resulted in the training of Prima-ry-Care Physicians (PCPs) to identify, diagnose, and treat common MHDs. As generalists, PCPs require specialised point-of-care clinical resources to educate their patients and provide them with evidence-based treatment plans; UpToDate is one such resource. As a database of synthesized peer-reviewed medical information, written and approved by physician-experts from their review of contemporary peer-reviewed literature, this resource is considered a gold standard. Here, we examine an MHD-spe-cific investigative case study on Generalized Anxiety Disorder where the synthesized UpToDate medical information was found to be in conflict with the original studies. In this era of unrelenting bombardment of digital data, the responsibility of assessing the truth of the information falls to the consumer. While a reliance on reputable information-sharing platforms facilitates both the access and assessment of truth, we discuss the risks of unintended errors, their propagation, and the potential impact at the point-of-care.
Bovine Adrenocortical Cytochrome P-45OI7, REGULATION OF GENE EXPRESSION BY ACTH AND ELUCIDATION OF PRIMARY SEQUENCE*

In the steroidogenic pathway of the adrenal cortex, 17a-hydroxylase cytochrome P-450 (P-45017,) is a ma- jor regulatory enzyme. Previous studies have shown that stimulation of 17a-hydroxylase activity occurs upon treatment of bovine adrenocortical cells in cul-ture with adrenocorticotropic hormone (ACTH), via CAMP, due to an increase in the enzyme concentration. Alterations in the levels of this enzyme result in pro- nounced changes in the pattern of steroids produced, with the potent glucocorticoid cortisol, as well as the sex steroids, being products of 17a-hydroxylated steroid precursors. In the present study, the identification and sequencing of two cloned DNA molecules, pB17a-1 and pcD17a-2, which are complementary to mRNA sequences encoding bovine adrenal cortex P-45017,, are reported. Clone pcD17a-2 contains an open reading frame coding for the complete amino acid sequence of P-45OI7, which consists of 509 amino acids and has a molecular weight of 57,251. By comparison to other forms of cytochrome P-450, we conclude that P-45017, is a member of a previously unidentified family within the P-450 multigene superfamily. Single bovine and human mRNA species of ~ 1 8 5 0 bases in length hybridize to these clones. Regulation of the concentration of this RNA has
Pioneering start-ups' first mover advantages and success factors in B2B service markets

Less attention has been given to first mover or pioneer advantages (FMA) for services than for physical products. Likewise, less attention has been given to FMA for business-to-business (B2B) markets than for business-to-customer markets. This research investigates FMA for B2B services using a grounded theory approach in existing academic knowledge, and by empirical analysis of university start-ups. Empirical analysis is performed through statistical analysis and Rough Set Analysis: a machine learning approach that induces decision rules for classification. Several patterns are evident from the data and a tool is introduced that can aid interested actors in assessing a start-up's performance based on several of its characteristics.
HYPERBARIC COLD STORAGE: PRESSURE AS AN EFFECTIVE TOOL FOR EXTENDING THE SHELF-LIFE OF REFRIGERATED MACKEREL (Scomber scombrus, L.)

The efficacy of hyperbaric cold storage for preserving lean fish has been recently demonstrated but, lamentably, no data exist for fatty fish. To evaluate the effect of hyperbaric cold storage on the shelf-life and quality of fatty fish, we stored Atlantic mackerel fillets at 5 °C, both at atmospheric pressure and at 50 MPa. After 12 days of hyperbaric storage, microbial counts were similar or even lower than those of control samples at day 0 and no significant lipid degradation was observed. By contrast, increased microbial counts and significant lipid hydrolysis were detected in the samples stored at atmospheric pressure. Moreover, even though the protein profile was significantly altered during hyperbaric storage, most fish-quality indicators (pH, TVB-N, drip loss, water holding capacity, and hardness after cooking) were better preserved in the mackerel samples stored at 50 MPa. These results clearly prove that hyperbaric cold storage was more efficient than conventional refrigeration for the preservation of Atlantic mackerel fillets. Industrial relevance: Long-term preservation of fatty fish is a challenge for the seafood industry mainly due to lipid degradation that can rapidly reduce fish quality. If effective against lipid degradation, hyperbaric cold storage could be an interesting technology to preserve fish and fish products. The increased cost resulting from hyperbaric storage should be overcome by an extended shelf-life of a high-quality product.
License Plate Recognition Using Support Vector Machine

Automatic license plate recognition (ALPR) system for vehicles is a challenging area of research due to its importance to a wide range of commercial applications. The first and the most important stage for any ALPR system is the localization of the license plate within the image captured by a camera. In this paper proposed approach is present. It has considered the Indian number plates, where rear follows the number plate standards. This system consist of few algorithm like "Feature based number plate Localization" for locating the number plate, "Image Scissoring" algorithm for character segmentation and proposed algorithm for character recognition using Support Vector Machine (SVM). System can recognize single or double line number plate.