Miracle-dz/UniFAR-FTUs huggingface dataset:
The Two Amino Acids Proximate to the Renin Cleavage Site of Human Angiotensinogen Do Not Affect Angiotensin II-mediated Functions in Mice

Objective Renin cleavage of angiotensinogen (AGT) has species specificity. Since the residues at positions 11 and 12 of AGT are different between human and mouse AGT, we determined whether these two residues in AGT affect renin cleavage and angiotensin II-mediated functions using an adeno-associated viral (AAV) approach for manipulating AGT in vivo. Approach and Results Hepatocyte-specific AGT deficient (hepAGT-/-) mice in an LDL receptor -/- background were infected with AAVs containing a null insert, human AGT, or mouse AGT expressing the same residues of the human protein at positions 11 and 12 [mouse AGT (L11V;Y12I)]. Expression of human AGT in hepAGT-/- mice led to high plasma human AGT concentrations without changes in plasma mouse endogenous AGT, plasma renin concentrations, blood pressure, or atherosclerosis. This is consistent with human AGT not being cleaved by mouse renin. To determine whether the residues at positions 11 and 12 in human AGT lead to the inability of mouse renin to cleave human AGT, hepAGT-/- mice were injected with AAV encoding mouse AGT (L11V;Y12I). Expression of mouse AGT (L11V;Y12I) resulted in increased plasma mouse AGT concentrations, reduced renin concentrations, and increased renal AngII concentrations that were comparable to their concentrations in hepAGT+/+ mice. This mouse AGT variant increased blood pressure and atherosclerosis in hepAGT-/- mice to the magnitude of hepAGT+/+ mice. Conclusion Replacement of L11 and Y12 to V11 and I12, respectively, in mouse AGT does not affect renin cleavage and AngII-mediated functions in mice. HIGHLIGHTS Human AGT is not cleaved by mouse renin and does not change AngII-mediated functions in hepatocyte-specific AGT -/- mice. Replacement of the N-terminal amino acids at 11 and 12 positions from mouse to human AGT does not affect renin cleavage and AngII-mediated functions in hepatocyte-specific AGT -/- mice.
Population Prediction Using Machine learning

The main objective of the paper is to find the best machine learning algorithm to predict the population outcome in the future. This paper discusses about the three algorithms, which are naïve Bayes, IBk and Random Trees. Machine learning tool used for running these algorithms is WEKA. In this test, WEKA is used to analyze the data and the three algorithms are added from the library. The data set is obtained from UCI repository and from number of instances available in the dataset, only limited number of instances is used to run the algorithm to keep the controlled environment for this test. Of all the three algorithms Naïve bayes algorithm shows the highest result.
Association Between Helicobacter Pylori Infection and Insulin Resistance: A Systematic Review

Abstract Most studies in the past decades show that screening of Helicobacter Pylori (HP) together with monitoring the inflammatory markers, plasma glucose and HbA1c levels can help prevent or delay type 2 diabetes mellitus. There is a double interrelation between HP infection and diabetes; thus diabetic patients are more susceptible to infection with HP via multiple mechanisms (decreased cellular and humoral immunity induced by diabetes, reducing gastrointestinal motility and secretion of hydrochloric acid, impaired glucose metabolism with the advent of chemical modifications of the gastric mucosa, the last two mechanisms favoring the intestinal colonization with HP). At the same time, those infected with HP can develop diabetes. The purpose of this paper is reviewing the data from the medical literature on the role of the chronic infection with HP on the induction of type 2 diabetes. The studies presented below lead us to the conclusion that the chronic infection with HP, in addition to local specific effects (simple gastritis, peptic ulcer and malignant diseases), also has extradigestive effects. The one approached in our work is that HP is being able to induce type 2 diabetes by complex mechanisms related to insulin resistance, chronic low-grade inflammation, decreased insulin secretion, and influences on glucose and lipid absorption.
Integrated reporting of environmental, social, and governance and financial data: Does the market value integrated reports?

The concept of reporting nonfinancial information within the annual report, so-called Integrated Reporting (IR) is a rising topic in reporting practice. Supporters claim that IR provides a better view regarding the value creation of a firm. This study investigates the value relevance of IR and the influence of certain characteristics such as assurance. Thus, this paper contributes to the existing literature by examining the actual advantages for firms when adopting an IR approach. The Ohlson model is applied for the market valuation of 50 companies of the STOXX Europe 50 between the years 2010 and 2016. The results of this study support the cost-concerned school by showing a negative influence on the market value. None-theless, the study suggests that the quality of the reports is relevant for market valuation, as the negative effect is mitigated by the quality of the reports.
Fostering toddlers’ social emotional competence: considerations of teachers’ emotion language by child gender

ABSTRACT The current study examines teachers’ differential emotion socialization practices with girls and boys by observing the emotion language of 27 teachers in naturally-occurring classroom interactions with 112 toddlers. This study explores the valence of teachers’ emotion language, the type of teachers’ emotion language, and the relation between teachers’ emotion language and toddlers’ social emotional competence, all by child gender. Results indicate that teachers use negative emotion language more than they use positive emotion language with boys, and emotion language differed by the type of language (labelling, questioning, explaining, or minimizing) for both genders. Additionally, teachers’ minimizing of negative emotions to boys was negatively associated with toddler boys’ social emotional competence. The current study offers implications for the ways in which we view, socialize, and measure social emotional competence by child gender.
Learning bipartite Bayesian networks under monotonicity restrictions

ABSTRACT Learning parameters of a probabilistic model is a necessary step in machine learning tasks. We present a method to improve learning from small datasets by using monotonicity conditions. Monotonicity simplifies the learning and it is often required by users. We present an algorithm for Bayesian Networks parameter learning. The algorithm and monotonicity conditions are described, and it is shown that with the monotonicity conditions we can better fit underlying data. Our algorithm is tested on artificial and empiric datasets. We use different methods satisfying monotonicity conditions: the proposed gradient descent, isotonic regression EM, and non-linear optimization. We also provide results of unrestricted EM and gradient descent methods. Learned models are compared with respect to their ability to fit data in terms of log-likelihood and their fit of parameters of the generating model. Our proposed method outperforms other methods for small sets, and provides better or comparable results for larger sets.
Sea Ice Automatic Extraction in the Liaodong Bay from Sentinel-2 Imagery Using Convolutional Neural Networks

Sea ice classification is one of the important tasks of sea ice monitoring. Accurate extraction of sea ice types is of great significance on sea ice conditions assessment, smooth navigation and safty marine operations. Sentinel-2 is an optical satellite launched by the European Space Agency. High spatial resolution and wide range imaging provide powerful support for sea ice monitoring. However, traditional supervised classification method is difficult to achieve fine results for small sample features. In order to solve the problem, this paper proposed a sea ice extraction method based on deep learning and it was applied to Liaodong Bay in Bohai Sea, China. The convolutional neural network was used to extract and classify the feature of the image from Sentinel-2. The results showed that the overall accuracy of the algorithm was 85.79% which presented a significant improvement compared with the tranditional algorithms, such as minimum distance method, maximum likelihood method, Mahalanobis distance method, and support vector machine method. The method proposed in this paper, which combines convolutional neural networks and high-resolution multispectral data, provides a new idea for remote sensing monitoring of sea ice.
The Effect of Arm Supports on Muscle Activity, Posture, and Discomfort in the Neck and Shoulder in Microscopic Dentistry: Results of a Pilot Study

OCCUPATIONAL APPLICATIONS When arm supports are provided during endodontic work, the use of the arm supports reduces static and median neck/shoulder muscle activity but does not seem to affect peak muscle activity. In addition, providing arm supports reduces the time working with unsupported upper arm angles <60°, but does not affect the time working unsupported with upper arm angles >60°. These results illustrate that in dentistry work in general, and in endodontic work specifically, dentists should be encouraged not only to optimize but also use their work environment to effectively reduce their workload. TECHNICAL ABSTRACT Background: Endodontic dentists treat dental nerves and tissues by performing precision tasks using a microscope. Their work is associated with a high prevalence of musculoskeletal symptoms. Purpose: This study was conducted to investigate the effect of the availability and use of arm supports on neck and shoulder load during endodontic work. Methods: A group of 11 endodontists performed an endodontic task under three arm support conditions: (1) using flexible arm supports; (2) using fixed arm supports; and (3) without arm supports. Surface electromyography, posture, and self-reported discomfort in the neck and shoulders were assessed as outcome measures. Results: Use of arm supports reduced static and median neck/shoulder muscle activity, but did not affect peak muscle activity. The presence of arm supports reduced the relative time working unsupported with upper arm angles <60°, but did not affect the time working unsupported with upper arm angles >60° or self-reported discomfort. Conclusions: When arm supports are provided during endodontic work, their use decreases neck/shoulder muscle activity and reduces the time working with non-neutral postures of the upper extremities. However, the clinical relevance of these findings needs to be evaluated in longitudinal field studies.
Laying Diet Supplementation with Ricinus communis L. leaves and Evaluation of Productive Performance and Potential Modulation of Antioxidative Status

This study evaluated the antioxidant capacity of Ricinus communis L. (RC) leaves and powder when used as a feed additive for laying hens. Results showed that the total phenolic content of the aqueous leaf extract of Ricinus communis L. (RCE) was 48.39 mg gallic acid equivalent (GAE) per gram dry weight (DW). The flavonoid content was 9.76 mg quercetin dihydrate equivalent (QE)/g DW. Ferrous chelating activity was approximately 56.2% with an RCE concentration of 1 mg/mL; the highest chelating activity was 91.2% with 4 mg/mL extract. The reducing power of 1 mg/mL RC was 1.17 times better than 1 mg/mL butylated hydroxytoluene (BHT). The Trolox equivalent antioxidant capacity (TEAC) value of 12.5 mg/mL RCE was equivalent to 3.09 mg/mL Trolox. RCE (10 mg/mL) had a lipid oxidative inhibition capacity of 35.3%. A total of 80 ISA brown laying hens at twenty-nine weeks of age were randomly allocated into the control or 1 of 3 treatment groups; the latter received 0.5%, 1% or 2% of RC, respectively, for 12 weeks. Results showed that the RC supplementation improved the feed conversion rate and 0.5% RC generated the best results. Additionally, the egg yolk score was significantly increased in all RC-supplemented groups. Moreover, there was no significant difference in serum characteristics between the treatment groups. Serum antioxidant enzyme activity showed that superoxide dismutase (SOD) activity increased in the RC-supplemented groups relative to the control but was not significantly different. mRNA expression levels of the antioxidant regulatory genes GCLC, GST, HO-1, SOD1, and SOD2 were significantly increased with 2% RC supplementation. In summary, RC is a suitable feed additive for laying hens and the addition of 0.5% RC leaf powder resulted in the greatest benefits.
Postpartum Acquired Hemophilia A: Case Report and Literature Review

Acquired Hemophilia A is a rare entity, resulting from the production of autoantibodies against factor VIII of the coagulation process. The presence of these autoantibodies, usually idiopathic, may be related to autoimmune conditions, drugs, neoplastic diseases and pregnancy. The diagnosis involves clinical aspects and laboratory findings, such as prolonged activated partial thromboplastin time, decreased levels of factor VIII and the presence of autoantibodies against it. The clinical manifestations of Acquired Hemophilia A are characterized by mucous-cutaneous, intramuscular, and/or postpartum bleeding. The treatment for Acquired Hemophilia A includes immunosuppressant drugs, reducing hemorrhages and intervening on the etiology of the inhibitor’s production. The authors report a case of Acquired Hemophilia A associated with pregnancy with several muco-cutaneous hemorrhagic manifestations and intramuscular hematomas with excellent response to the use of immunosuppressants.
Influence of Manila clam aquaculture on rates and partitioning of organic carbon oxidation in sediment of Keunso Bay, Yellow Sea

We investigated the effects of Manila clam aquaculture on the rates and pathways of anaerobic organic carbon (OC) oxidation in highly bioturbated (HB) and poorly bioturbated (PB) sediment in Keunso Bay, Yellow Sea. Due to the labile organic matter supply via sediment reworking by Manila clams, the anaerobic OC oxidation rate in HB sediment (38.8 mmol m-2 d-1) was ~1.5 times higher than that in PB sediment (26.8 mmol m-2 d-1). Microbial Fe(III) reduction (FeR) dominated OC oxidation pathways in HB sediment, comprising 55 to 76% of anaerobic OC oxidation, whereas sulfate reduction (SR) was the dominant oxidation pathway in PB sediment, accounting for up to 92% of anaerobic OC oxidation. Despite higher anaerobic respiration rates at the HB site, concentrations of NH4+, PO43-, oxalate-extractable iron (Fe(II)(oxal)), and total reduced inorganic sulfur were 2 to 3 times lower in HB than in PB sediment. Conversely, the concentration of reactive Fe(III)(oxal) at the HB site (2243 mmol m-2) exceeded that at the PB site (1127 mmol m-2) by a factor of 2. These results indicate that bioturbation by Manila clams enhances the re-oxidation processes of reduced metabolites in the sediment, thereby prohibiting SR and promoting FeR. Overall, the results suggest that aquaculture activities of Manila clams shift the dominant OC oxidation pathways in sediment from SR to FeR, which generates relatively oxidized and less sulfidic environments.
Control of Dichelops melacanthus with insecticides associated with sulphur applied in different times in corn

The stink bug Dichelops melacanthus has become an important pest for corn crop and it has been causing several losses even in the initial phase of the crop. The objective of the experiment was the evaluation of effectiveness of the insecticides on the control of D. melacanthus in corn by adding of sulfur or not, in different control times. In order to evaluate the effect of the insecticide by adding or not sulfur on the control of D. melacanthus , 17 treatments with 4 different insecticides (with and without sulfur, in two different control times plus control) were used to get the results. The experimental design used was the randomized blocks, with four repetitions. The evaluation of effectiveness on stink bugs control was gotten by visual evaluation of the symptoms at 6, 13 and 20 days after emergence (DAE). Analysis of variance by F test (Anova) was done and the averages compared through Scott-knott test (p≤0,05). The pulverization of insecticides was more effective when it was done 4 (DAE), reducing the symptoms and injuries occasioned by the stink bug D. melacanthus and the mortality of damaged plants. The insecticide bifentrina+carbosulfano showed the higher effectiveness on stink bug control. To conclude, the use of sulfur associated to insecticides did not present a significant effect.
The prognostic value of preoperative serum HDL cholesterol in patients with resectable acral melanoma

Background: Acral melanoma is dominant in Asia, which differs from cutaneous melanoma in etiology, mutation loading, and therapy response. Growing evidence indicates that various components of the lipid profile may be associated with cancer clinical outcomes and the disrupted cholesterol homeostasis plays a potential role in melanoma development. Therefore, we examined the prognostic value of the preoperative serum lipid profile in patients with acral melanoma. Methods: This is a retrospective study consisting of 239 patients who underwent radical surgical resection for acral melanoma between 2000 and 2011 at Sun Yat-sen University Cancer Center. Kaplan-Meier survival analysis and Cox proportional model were used to calculate overall survival (OS) and diseasefree survival (DFS). Results: Elevated HDL-C levels were significantly associated with longer OS both in univariate (P<0.001) and multivariate (P=0.005) analyses. The median OS of patients with a low HDL-C level was worse than those with a high HDL-C level (38.09 vs. 50.1 months, HR: 2.63). Univariate analyses showed that a shorter DFS was associated with a low HDL-C level (P<0.001) and was still obviously in the multivariate analysis (P=0.043). The median DFS of patients with a low HDL-C level was worse than those with a high HDL-C level (17.26 vs. 30.09 months, HR: 1.739). There was no significant difference in the OS or DFS based on LDL-C, CHO, and TG levels. Conclusion: Preoperative serum HDL-C may serve as a valuable marker to predict the outcomes of acral melanoma patients.
Becoming with Clothes : Activating wearer-worn engagements through design

6 frequenTly aSSoCiaTed with the superficial and the frivolous, fashion has been treated as a subject of lowly relevance in both practice and research. Not exclusive to fashion, this overvaluation of the superficial and the visual has deemed the relationships between individuals and designed artefacts as weak and unengaged. In order to shift this state of affairs, this research asks about paths towards more active engagements between wearer and worn. More specifically, it is interested in understanding how fashion designers can support this change through practice. In order to answer this question, the experiences between wearer and worn and the ways these two entities interact become a central matter of concern. The realm of experience has been marginalised in the considerations of fashion studies as they have privileged investigations on fashion as a system of signification. Through a literature review, this research
Effects of a group-deposit prize draw on the step counts of adults

By Alex J. McCurdy University of the Pacific 2019 The World Health Organization (WHO, 2016) reports that 3.2 million deaths per year are attributable to physical inactivity, making it the fourth leading risk factor for global mortality. Physical inactivity is also a key risk factor for noncommunicable diseases such as cardiovascular disease, cancer, and diabetes (WHO, 2018). Globally, 1 in 4 adults is not active enough and, therefore, foregoes a myriad of health benefits associated with Physical Activity (PA; WHO, 2018). In the United States, only about 1 in 5 (21%) adults meet the 2008 Physical Activity Guidelines set by the Centers for Disease Control and Prevention (CDC, 2018). The CDC currently recommends adults engage in 150 min of moderate-intensity aerobic activity per week (CDC, 2018). Translated to steps, the recommendation can be met by taking 3,000 steps in 30 min, 5 days per week (Marshall et al., 2009). Physical inactivity is also a major contributor to obesity (WHO, 2018). According to the WHO (2018), worldwide prevalence of obesity almost tripled since 1975. In the United States, the medical costs of obesity were estimated to be $147 billion, or 10% of all medical spending (Finkelstein, Trogdon, Cohen, & Dietz, 2009). To combat the many problems associated with physical inactivity, the CDC (2015), the WHO (2018), and the American Heart Association (2018) prescribe increased PA. Furthermore, increased PA contributes to a variety of other health benefits, including a decreased risk for
Dependence of the Interplanetary Magnetic Field on Heliocentric Distance at 0.3–1.7 AU: A Six‐Spacecraft Study

We use magnetometer data taken simultaneously by MESSENGER, VEX, STEREO and ACE to characterize the variation of the interplanetary magnetic field (IMF) with heliocentric distance, rh , for rh≲ 1 AU. Power law fits ( arhb ) to the individual IMF components and magnitude indicate that, on average, the IMF is more tightly wound and its strength decreases less rapidly with rh than the Parker spiral prediction. During Solar Cycle 24, temporal changes in b were insignificant, but changes in amplitude, a , were correlated with sunspot number, up to sunspot number ∼ 84. MAVEN data taken at 1.4–1.7 AU since late 2014 broadly confirm and extend these results in space and time. Our study demonstrates the importance of simultaneous observations from multiple spacecraft to separate heliocentric distance and temporal variations in the IMF and provides a modern benchmark for comparison with data from the Parker Solar Probe Mission.
Promotion of lactation amenorrhea method intervention trial, Kazakhstan

As a member of the Soviet Union the Republic of Kazakhstan adopted a national policy encouraging mothers to use artificial foods in lieu of breastfeeding to enable mothers to return to the workforce soon after giving birth. This practice of lactation management used in Kazakhstan and in other republics of the former USSR separated newborn infants from their mothers in maternity wards first placed infants on their mothers’ breasts late after delivery and advocated feeding on a fixed schedule. Additionally the program promoted supplementary feedings of a boiled water and glucose formula during the first days of infancy and advocated substantial supplementary feeding in the first or second months after delivery. As a result many women lost the benefits of breastfeeding as a means of natural pregnancy prevention. In 1997 the government reformulated its policy on breastfeeding reversing the former norms and once again encouraging mothers to breastfeed their children under a “national program on protecting promoting and supporting breastfeeding. ” In order to expand the benefits of breastfeeding as a birth spacing option for women in the Republic of Kazakhstan the Kazakh Academy of Nutrition at the Academy of Preventive Medicine in Almaty conducted an operations research study to test the effectiveness of Lactation Amenorrhea Method (LAM) promotion among women in Kazakhstan as part of the Population Council’s Frontiers in Reproductive Health Small Grants Program. In the Promotion of Lactation Amenorrhea Method Intervention Trial (PLAMIT) researchers trained maternity ward staff in four hospitals to provide patient counseling on the benefits of LAM as a family planning method while five comparison hospitals received no additional support. After the intervention they observed the breastfeeding habits of 3969 women and 4003 children in all nine hospitals and conducted a total of eight interviews over 12 months with each mother. Reproductive and child health outcomes were compared according to the status of the hospital as intervention or control and Baby-Friendly (those that are certified according to UNICEF standards) or ordinary (not Baby-Friendly). This report presents only results related to family planning. (excerpt)