Miracle-dz/UniFAR-FTUs huggingface dataset:
In-hospital mortality risk assessment in elective and non-elective cardiac surgery: a comparison between EuroSCORE II and age, creatinine, ejection fraction score.

OBJECTIVES Age, creatinine, ejection fraction (ACEF) score is a simplified algorithm for prediction of mortality after elective cardiac surgery. Although mainly conceived for elective cardiac surgery, no information is available on its performance in non-elective surgery and on comparison with the new EuroSCORE II. This study was undertaken to compare the performance of ACEF score and EuroSCORE II within classes of urgency. METHODS Complete data on 13 871 consecutive patients who underwent major cardiac surgery in a 6-year period were retrieved from three prospective institutional databases. Discriminatory power was assessed using the c-index and h with Delong, bootstrap and Venkatraman methods. Calibration was evaluated with calibration curves and associated statistics. RESULTS The in-hospital mortality rate was 2.5%. The discriminatory power of ACEF score within elective and non-elective surgery was similar (area under the curve (AUC) 0.71, 95% confidence interval (CI) 0.67-0.74 and AUC 0.68, 95% CI 0.62-0.73, respectively) but significantly lower than that of EuroSCORE II (AUC 0.80, 95% CI 0.77-0.83 for elective surgery; AUC 0.82, 95% CI 0.78-0.85 for non-elective surgery). The calibration patterns were different in the two subgroups, but the summary statistics underscored a miscalibration in both of them (U-statistic and Spiegelhalter Z-test P-values <0.05). Even the calibration of EuroSCORE II was insufficient, although it was demonstrated to be well calibrated in the first tertile of predicted risk. CONCLUSIONS This study demonstrated that the performance of ACEF score in predicting in-hospital mortality in elective and non-elective cardiac surgery is comparable. Nonetheless, it is not as satisfactory as the new EuroSCORE II, as its discrimination is significantly lower and it is also miscalibrated.
Dynamic Visual Abstraction of Soccer Movement

Trajectory‐based visualization of coordinated movement data within a bounded area, such as player and ball movement within a soccer pitch, can easily result in visual crossings, overplotting, and clutter. Trajectory abstraction can help to cope with these issues, but it is a challenging problem to select the right level of abstraction (LoA) for a given data set and analysis task. We present a novel dynamic approach that combines trajectory simplification and clustering techniques with the goal to support interpretation and understanding of movement patterns. Our technique provides smooth transitions between different abstraction types that can be computed dynamically and on‐the‐fly. This enables the analyst to effectively navigate and explore the space of possible abstractions in large trajectory data sets. Additionally, we provide a proof of concept for supporting the analyst in determining the LoA semi‐automatically with a recommender system. Our approach is illustrated and evaluated by case studies, quantitative measures, and expert feedback. We further demonstrate that it allows analysts to solve a variety of analysis tasks in the domain of soccer.
Linear Discriminative Star Coordinates for Exploring Class and Cluster Separation of High Dimensional Data

One main task for domain experts in analysing their nD data is to detect and interpret class/cluster separations and outliers. In fact, an important question is, which features/dimensions separate classes best or allow a cluster‐based data classification. Common approaches rely on projections from nD to 2D, which comes with some challenges, such as: The space of projection contains an infinite number of items. How to find the right one? The projection approaches suffers from distortions and misleading effects. How to rely to the projected class/cluster separation? The projections involve the complete set of dimensions/features. How to identify irrelevant dimensions? Thus, to address these challenges, we introduce a visual analytics concept for the feature selection based on linear discriminative star coordinates (DSC), which generate optimal cluster separating views in a linear sense for both labeled and unlabeled data. This way the user is able to explore how each dimension contributes to clustering. To support to explore relations between clusters and data dimensions, we provide a set of cluster‐aware interactions allowing to smartly iterate through subspaces of both records and features in a guided manner. We demonstrate our features selection approach for optimal cluster/class separation analysis with a couple of experiments on real‐life benchmark high‐dimensional data sets.
Delayed success of balloon dilation for coexisting pulmonary valve stenosis and sinotubular narrowing.

OBJECTIVES We evaluated the outcomes of children at a single institution who underwent balloon pulmonary valvuloplasty (BPV) for coexisting pulmonary valve stenosis (PVS) and sinotubular narrowing (STN). BACKGROUND BPV is the treatment of choice for PVS in children. Current practice favors surgical repair of moderate, severe, and symptomatic pulmonary stenosis when STN exists. This practice arose from lack of reduction in total pulmonary gradient (TPG) and frequent adverse events from BPV. METHODS A retrospective analysis of outcomes in children with coexisting PVS and STN following BPV at a single institution was performed. RESULTS Twenty-three patients were identified. Median age at BPV was 0.5 years (interquartile range (IQR) 0.3-2). Surgery was avoided in 15/23 (65%) (Group 1) and required in 8/23 (35%) (Group 2) following BPV. Group 1 had a mean baseline peak echo TPG of 60 mm Hg (±12) that decreased to 44 mm Hg (±10) following BPV (P < 0.01) and further to 21 mm Hg (±13) at 3.6 years (±2.2) following BPV (P < 0.01). Group 2 had a mean baseline peak echo TPG of 68 mm Hg (±17). TPG was unchanged by first echo after BPV at 56 mm Hg (±13) and just prior to surgery at 63 mm Hg (±15) (P > 0.10). CONCLUSIONS BPV has minimal acute effect on PVS when STN exists; however; long-term benefits are achieved in most. BPV should be considered first-line therapy given its safety and effectiveness. Only those with worsening clinical signs and symptoms should be referred for surgical repair following BPV.
Severe acute respiratory syndrome-coronavirus and human coronavirus-NL63: an updated overview

Severe acute respiratory syndrome-coronavirus and human coronavirus-NL63, though both belonging to different groups of the same genus, are interesting representatives of their kind; the first one is of zoonotic origin, accounted for the pandemic in 2002/2003 that was distributed worldwide and had a mortality rate of about 10%, the other one was identified later and probably has been circulating within the population for centuries and belongs to those viruses that cause the ‘common cold’. A lot of effort has been made to investigate both viruses and to understand their differences and their similarities with regard to further zoonotic events. This review gives an overview of severe acute respiratory syndrome-coronavirus and human coronavirus-NL63, their history and the current state of research.
General surgery resident remediation and attrition: a multi-institutional study.

OBJECTIVE To determine the rates and predictors of remediation and attrition among general surgery residents. DESIGN, SETTING, AND PARTICIPANTS Eleven-year retrospective analysis of 348 categorical general surgery residents at 6 West Coast programs. MAIN OUTCOME MEASURES Rates and predictors of remediation and attrition. RESULTS Three hundred forty-eight categorical general surgery residents were included. One hundred seven residents (31%) required remediation, of which 27 were remediated more than once. Fifty-five residents (15.8%) left their programs, although only 2 were owing to failed remediation. Remediation was not a predictor of attrition (20% attrition for those remediated vs 15% who were not [P = .40]). Remediation was most frequently initiated owing to a deficiency in medical knowledge (74%). Remediation consisted of monthly meetings with faculty (79%), reading assignments (72%), required conferences (27%), therapy (12%), and repeating a clinical year (6.5%). On univariate analysis, predictors of remediation included receiving honors in the third-year surgery clerkship, United States Medical Licensing Examination (USMLE) step 1 and/or step 2, and American Board of Surgery In-Training Examination scores at postgraduate years 1 through 4. On multivariable regression analysis, remediation was associated with receiving honors in surgery (odds ratio, 1.9; P = .01) and USMLE step 1 score (odds ratio, 0.9; P = .02). On univariate analysis, the only predictor of attrition was the American Board of Surgery In-Training Examination score at the postgraduate year 3 level (P = .04). CONCLUSIONS Almost one third of categorical general surgery residents required remediation during residency, which was most often owing to medical knowledge deficits. Lower USMLE step 1 scores were predictors of the need for remediation. Most remediated residents successfully completed the program. Given the high rates of remediation and the increased educational burden on clinical faculty, medical schools need to focus on better preparing students to enter surgical residency.
Minimally invasive mitral valve surgery without aortic cross-clamping and with femoral cannulation is not associated with increased risk of stroke compared with traditional mitral valve surgery: a propensity score-matched analysis.

OBJECTIVES Open-heart surgery with fibrillatory arrest has been reported to be associated with an increased risk of stroke. We examined whether minimally invasive mitral valve surgery with fibrillatory arrest conferred a higher risk of stroke/transient ischaemic attack (TIA) and other major complications compared with median sternotomy and cardioplegic arrest. METHODS Data were collected prospectively for 387 patients who had mitral valve surgery; 239 had a minimally invasive surgical approach and 148 had median sternotomy. All minimally invasive surgeries were performed by surgeons who were experienced in minimally invasive techniques. The effect of operative approach on risk of stroke/TIA and major morbidity was examined. After propensity score matching (PSM) was conducted between the two groups, 76 patients remained in each group. RESULTS Before matching, the incidence of stroke/TIA did not differ between patients who had minimally invasive surgery (0.5%, n = 1) and those who had median sternotomy (1.4%, n = 2; P = 0.56). Patients who had minimally invasive surgery had a lower incidence of other major morbidity (0.8%, n = 2) than patients who had median sternotomy (6.1%, n = 9; P = 0.004). After adjustment for age and Society of Thoracic Surgeons predicted risk, there was no effect of operative approach on the odds for stroke/TIA (odds ratio [OR] = 0.41, P = 0.49) or other major morbidity (OR = 0.40, P = 0.31). After PSM, patients were balanced on preoperative characteristics. No patient in either matched group experienced permanent stroke/TIA, and major morbidity did not differ between the two groups (minimally invasive, 1.3%, n = 1; median sternotomy, 1.3%, n = 1; P > 0.99). CONCLUSIONS A minimally invasive approach for mitral valve surgery on a fibrillating heart was not associated with a greater incidence of stroke/TIA than was median sternotomy. When performed by highly experienced surgeons, the minimally invasive approach with fibrillatory arrest did not increase the risk of perioperative stroke.
Sleep Disturbance and its Association with Suicidal Ideation in Veterans

Suicide is a major public health focus with increasing importance among veterans. Post-traumatic stress disorder (PTSD), depression, and alcohol use are associated with increased rates of suicidal thoughts, with some indications that suicide is also linked to sleep disturbance. The current study examined the association of sleep disturbance with suicidal ideation (SI) among 654 veterans. Logistic regression revealed that after controlling for age, alcohol dependence, depression, and PTSD, sleep disturbance remained associated with SI. In this sample of veterans, the relationship of sleep disturbance to SI does not appear to be solely attributable to comorbid factors. Identification of sleep difficulties may aid in the early detection of SI, allowing for intervention prior to symptom escalation.
Development of a novel breakfast food product for primary school children in an informal settlement

A baseline survey on the nutritional status of primary school children was conducted by means of Quanlitati e Food Frequency Questionnaire (QFFQ) and the 24-Hr recall questionnaires. The questionnaires were distributed by trained fieldworkers and completed by children attending the primary school in this community. The results of the QFFQ and the 24-Hr recall were used to identify nutrient deficiencies in the target group and to design a food product for a school feeding programme targeted to address specific nutritional needs. The aim of this study was to develop a nutritious novel food product that was affordable and appealing to children, rich in energy, protein and micronutrients. Five recipes were originally tested and evaluated. Recipes were theoretically analyzed by using the Dietary Manager program. The three mosl suitable recipes were chosen. Sensory analysis, by means of a paired preference test was done to determine which of the three products the subjects preferred. The final product developed was a maize meal and whole wheal "vell-oel-". The Agricultural Research Council (ARC) laboratory in Irene bio-chemically analysed the velkoek. A second sensory analysis was conducted to evaJuate the product for acceptability. A smiley face evaluation sheet was developed for the acceptance testing. The results showed that the majonty (65 percent) of the consumers liked the product very much, 18 percent liked the product moderately, and 17 percent found it acceptable, 90 percent found it to be acceptable for inclusion in a school-feeding program. After the sensory evaluation was done a trained microbiologist at the ARC conducted the shelf life testing. A recipe pamphlet was developed and printed in a fonnat that is easily understood by illiterate people. The pamphlet was used by the community workers, who were responsible for preparing the vetl-oek. The results indicated that a vetkoel. , meeting all the stated criteria can successfully be developed for a school programme
The Dual Edema-Preventing Molecular Mechanism of the Crataegus Extract WS 1442 Can Be Assigned to Distinct Phytochemical Fractions

Abstract The hawthorn (Crataegus spp.) extract WS 1442 is used against mild forms of chronic heart failure. This disease is associated with endothelial barrier dysfunction and edema formation. We have recently shown that WS 1442 protects against this dysfunction by a dual mechanism: it both promotes endothelial barrier integrity by activation of a barrier-enhancing pathway (cortactin activation) and inhibits endothelial hyperpermeability by blocking a barrier disruptive pathway (calcium signaling). In this study, we aimed to identify the bioactive compounds responsible for these actions by using a bioactivity-guided fractionation approach. From the four fractions generated from WS 1442 by successive elution with water, 95 % ethanol, methanol, and 70 % acetone, only the water fraction was inactive, whereas the other three triggered a reduction of endothelial hyperpermeability. Analyses of intracellular calcium levels and cortactin phosphorylation were used as readouts to estimate the bioactivity of subfractions and isolated compounds. Interestingly, only the ethanolic fraction interfered with the calcium signaling, whereas only the methanolic fraction led to an activation of cortactin. Thus, the dual mode of action of WS 1442 could be clearly assigned to two distinct fractions. Although the identification of the calcium-active substance(s) was not successful, we could exclude an involvement of phenolic compounds. Cortactin activation, however, could be clearly attributed to oligomeric procyanidins with a distinct degree of polymerization. Taken together, our study provides the first approach to identify the active constituents of WS 1442 that address different cellular pathways leading to the inhibition of endothelial barrier dysfunction.
Chemical Composition of Curcuma Longa Leaves and Rhizome Oil from the Plains of Northern India

Hydro distillation of rhizomes and leaves of Curcuma longa resulted in the isolation of 0.36% and 0.53% of oils (w/v) respectively on a fresh weight basis. GC and GC-MS analysis resulted in the identiÞ cation of 73 constituents in rhizomes comprising 95.2% of the oil, of which the major ones were ar-turmerone (31.7%), α-turmerone (12.9%), β-turmerone (12.0%) and (Z) β-ocimene (5.5%). In the oils, 75 constituents comprising 77.5% of the oils were identiÞ ed, the major ones were α-phellantrene (9.1%), terpinolene (8.8%), 1,8-cinceole (7.3%), undecanol (7.1) and p-cymene (5.5%). Key words: Curcuma longa; Zingiberaceae, rhizomes, leaves, essential oil composition, GC-MS.
Visual field progression in patients with open-angle glaucoma

s (n = 23) Article not available in the Netherlands (n = 35) No direct comparisons between methods (n = 364) 48 articles fulfilled the selection criteria Additional exclusion criteria for the meta-analysis No Humphrey Field Analyzer (n = 8) No reporting of incidence of progression (n = 10) No connections with the network (n = 5) Overlap of patients with other studies in the network (n = 10) Pre-selected progressive patients (n = 2) Methods were applied on different groups (n = 1) 12 articles were included in the meta-analysis Figure 1: Flow chart of the article selection process Finally, the data of twelve articles were combined in the network meta-analysis (figure 1). Three articles were included that studied different methods in the same population during the same follow-up period. Data of these articles were treated as a single study. The references of all included articles were additionally screened to identify more studies. This did not result in additional articles. However, we found one recent article that described the same study as one of the included articles. Since additional methods were applied in this article, we added these methods to the meta-analysis.
Nutrition for Health and Health Care

1. OVERVIEW OF NUTRITION AND HEALTH. Nutrition in Practice: Finding the Truth about Nutrition. 2. DIGESTION AND ABSORPTION. Nutrition in Practice: Food Safety. 3. CARBOHYDRATES. Nutrition in Practice: The Glycemic Index in Nutrition Practice. 4. LIPIDS. Nutrition in Practice: Figuring Out Fats. 5. PROTEIN. Nutrition in Practice: Vegetarian Diets. 6. ENERGY BALANCE AND BODY COMPOSITION. Nutrition in Practice: Fad Diets. 7. WEIGHT MANAGEMENT: OVERWEIGHT AND UNDERWEIGHT. Nutrition in Practice: Eating Disorders. 8. THE VITAMINS. Nutrition in Practice: Phytochemicals and Functional Foods. 9. WATER AND THE MINERALS. Nutrition in Practice: Vitamin and Mineral Supplements. 10. NUTRITION THROUGH THE LIFE SPAN: PREGNANCY AND INFANCY. Nutrition in Practice: Encouraging Successful Breastfeeding. 11. NUTRITION THROUGH THE LIFE SPAN: CHILDHOOD AND ADOLESCENCE. Nutrition in Practice: Childhood Obesity and the Early Development of Chronic Diseases. 12. NUTRITION THROUGH THE LIFE SPAN: LATER ADULTHOOD. Nutrition in Practice: Hunger and Community Nutrition. 13. NUTRITION CARE AND ASSESSMENT. Nutrition in Practice: Nutritional Genomics. 14. NUTRITION INTERVENTION AND DIET-DRUG INTERACTIONS. Nutrition in Practice: Complementary and Alternative Therapies. 15. ENTERAL AND PARENTERAL NUTRITION SUPPORT. Nutrition in Practice: Inborn Errors of Metabolism. 16. NUTRITION IN METABOLIC AND RESPIRATORY STRESS. Nutrition in Practice: Multiple Organ Dysfunction Syndrome. 17. NUTRITION AND UPPER GASTROINTESTINAL DISORDERS. Nutrition in Practice: Nutrition and Oral Health. 18. NUTRITION AND LOWER GASTROINTESTINAL DISORDERS. Nutrition in Practice: Probiotics and Intestinal Health. 19. NUTRITION AND LIVER DISEASES. Nutrition in Practice: Alcohol in Health and Disease. 20. NUTRITION AND DIABETES MELLITUS. Nutrition in Practice: Metabolic Syndrome. 21. NUTRITION AND DISORDERS OF THE HEART AND BLOOD VESSELS. Nutrition in Practice: Helping People with Feeding Disabilities. 22. NUTRITION AND RENAL DISEASES. Nutrition in Practice: Dialysis. 23. NUTRITION, CANCER, AND HIV INFECTION. Nutrition in Practice: Ethical Issues in Nutrition Care.
Plate-rod technique with engraftment of platelet rich plasma seeded hydroxyapatite for fracture management of tibia in a blackbuck (Antelope cervicapra).

An adult one year old female Black Buck, weighing about 20kg, maintained in Arignar Anna Zoological Park, Vandallur, Chennai was referred to Madras Veterinary College with a complaint of non-weight bearing lameness on the left hind limb. Physical examination and radiogram revealed comminuted fracture of left tibia with cranially displaced bone fragments. Plate-rod technique of biologic osteosynthesis was performed with adjunct therapy of engraftment of autologous platelet rich plasma seeded hydroxyapatite which provided better clinical outcome without post-operative complication and early ambulation. Plate-rod technique of biologic osteosynthesis in combination with engraftment of autologous platelet rich plasma seeded hydroxyapatite for the management of tibial fracture improved the clinical outcome in a Black buck.
Using the Concerns Based Adoption Model (CBAM) to Evaluate Teachers’ Concerns About the CAC in Three (3) Primary Schools in the Caroni Education District

Using the Concerns Based Adoption Model (CBAM) to Evaluate Teachers’ Concerns About the CAC in Three (3) Primary Schools in the Caroni Education District Ancyia Ramoutar-Bhawan Employing the Concerns Based Adoption Model (CBAM) as its theoretical framework, this study evaluated the concerns of six teachers at three primary schools in the Caroni Educational District of Trinidad and Tobago about the Continuous Assessment Component (CAC) of the Secondary Entrance Assessment (SEA) examination. Data were collected through interviews. The major findings of the study indicated that the teachers’ most intense concerns were in the awareness, informational, personal, and management stages of concerns. They had deep self-concerns (need for information on training, support systems, school policy for CAC) and task concerns (time management, resource allocation, management of assessment system).
The prognostic accuracy of resonance frequency analysis in predicting failure risk of immediately restored implants.

OBJECTIVES It is of imperative clinical significance to define a safe threshold for planned immediate implant restoration. The aim of this report was to evaluate the prognostic accuracy of resonance frequency analysis (RFA) measurements recorded at two different times (implant placement and 8-week post-implant placement) and to determine the optimal threshold value for predicting failure risk of immediately restored/loaded implants. MATERIAL AND METHODS Twenty-eight 8- or 9-mm-diameter implants were placed in either a fresh molar extraction socket or a healed site. An electronic RFA device was used to record the implant stability quotients (ISQs) at implant placement surgery, 8 weeks and 1 year. Receiver operating characteristic (ROC) analysis was used to identify the optimal cut-off level. Sensitivity and specificity were also determined at the selected cut-off value. RESULTS The area under the ROC curve for RFA at 8 weeks was 0.93 with a significant P-value (P = 0.001). The optimum cut-off value for detecting implant stability was 60.5 ISQ measured at 8 weeks, with sensitivity and specificity of 95.2% and 71.4%, respectively. CONCLUSIONS The implant stability measurements after 8 weeks showed a better accuracy in predicting implants that were at risk of failure than those taken at the time of implant placement.