Miracle-dz/UniFAR-FTUs huggingface dataset:
Behavior of adult bottle brush weevils ( Rhinostomus barbirostris ) (Coleoptera: Curculionidae)

Several striking secondary sexual characters of the weevil Rhinostomus barbirostris serve as weapons in intraspecific battles between males for females about to oviposit. Smaller males adopt two alternative behavioral tactics in these battles which seem designed to minimize the loss in reproduction which would otherwise result from their inferior fighting abilities. Although the beetles may thus be polymorphic for fighting behavior, there was no sign of morphological dimorphisms. The sizes of their weapons (long rostra) were linearly rather than geometrically related to the sizes of other body parts. The males' behavior suggests that there is strong sperm precendence in this species.
EFFECT OF GUAVA (Psidium guajava) CREAM ON THE GROSS AND MICROSCOPIC FEATURES AND HEALING RATE OF INCISIONAL WOUNDS IN DOMESTIC SHORT-HAIRED CATS

The study was conducted to investigate the feasibility of guava cream as replacement for topical antibiotic for wound healing. Twelve cats were divided into four groups and subjected to different concentrations of guava cream: 0% (antibiotic wound cream group), 1%, 3% and 5% having 3 animals per group. A dorsal midline incision (at the level of T6 to T7, with a length of 2.5 centimeters in full thickness) was made and was left open for second intention healing. A thin layer of cream was applied over the wound every other day starting day 0 until day 20 and an incisional biopsy was done at day 0, 7, and 14. Wound contraction and gross appearance was graded. There was no significant difference (P<0.05) on the effect of wound healing of the different percentages of guava cream compared to the wound cream however, the results of the 3% and 5% guava cream had a faster wound contraction. All treatments of guava cream produced comparable results with the antibiotic wound cream therefore, this study concludes that guava cream can be used as an alternative antiseptic and antibacterial treatment for wounds.
A SYSTEM FOR ACUTE LEUKEMIA CELLS SEGMENTATION AND CLASSIFICATION

This research paper presents a system for the acute leukemia blast cells segmentation and classification. The research objective is to generate the features characterizing normal and infected cells. The proposed system consists of one segmentation method and one classification method of acute leukemia. The features extracted from the cell and adopted features are used as the input signals to the Multi Layer Perception (MLP) neural network classifier. The experimental results show that our proposed system is robust and effective in identifying acute leukemia blast cells. Keywords—Image Segmentation, ALL , RGB, C-Y color model, Features Extraction, MLP.
Myocardial Ischemia Detection from Slope of ECG ST Segment

Myocardial ischemia occurs when blood flow to heart is reduced preventing it from receiving enough oxygen. It is a possible indication of partial or complete blockage of coronary arteries. Though ischemia is accompanied by symptoms (fatigue, chest pain, shortness of breath etc.) sometimes it can be silent. If not treated, it can lead to various heart diseases. Most importantly it can progress to myocardial infarction (heart attack), which can be fatal. Thus detecting ischemia at an early stage is important to prevent serious implications. Nowadays personal healthcare monitoring systems are used which provide vital physiological information. In future ECG measurement devices would also be common in homes. So, the proposed work intends to develop an algorithm in detecting myocardial ischemia from ECG, which would be computationally less complex and easy to implement in homecare ECG devices. One way to do it is through continuous or long term monitoring of ECG. The ST segment elevation (or depression) indicates presence of ischemia. The proposed method measures slope of ST segment which must vary in case of ST changes. The algorithm is tested on selected records of the European ST-T database and returns an accuracy of 83.33%. Bangladesh Journal of Medical Physics Vol.10 No.1 2017 12-24
A comparative and correlative study of serum homocysteine level in gestational diabetes mellitus and normal pregnancy

Background: An alarming increase in Gestational diabetes mellitus (GDM) cases worldwide elevates concern regarding the consequences including fetal macrosomia, preeclampsia and many more. Plasma homocysteine levels which has direct impact on to endothelial function of blood vessels. The relationship of homocysteine and GDM is yet to be clarified.Methods: This single centre prospective observational study was conducted in Department of Obstetrics and Gynaecology of Thanjavur medical college hospital among 50 pregnant primi and multi gravida patients with normal pregnancy and gestational diabetes mellitus to assess the association and comparison of serum homocysteine levels in both groups.Results: The mean value of homocysteine in control group was 3.8 ± 0.95 and in gestational diabetes patients was 16.30±6.09. On comparison, found that there was hyperhomocysteinemia among GDM patients with normal pregnancy and results were statistically significant (T= -9.024 Df=48.000 <0.05). Conclusions: In this comparative and correlative study, we found that patients with gestational diabetes mellitus have higher serum homocysteine levels in comparison with normal pregnant women. Hyperhomocysteinemia is found to be an independent risk factor for gestational diabetes mellitus patients. Further investigations are needed to follow up for these patients in the postpartum period and later in their life.
Preliminary Results of Oxygen-ozone Therapy as Support and Palliative Therapy in Cancer Patients with Fatigue

All cancer treatments may cause fatigue and it is hypothesized that the cause is tissue damage, or the accumulation of products derived from dead cells. From February 2016 to December 2017 we have studied 36 patients with cancer and fatigue (10 with breast cancer, 7 with lung cancer, 7 with colon cancer, 5 with renal cancer, 3 with prostate cancer, 2 with melanoma and 2 hepatocellular carcinoma). Of the 36 patients treated, 10 were during neoplastic treatment, 10 had already finished the cancer therapy and 16 were in a palliative setting. To assess the extent of fatigue in patients we used the Fatigue Severity Scale, which is used to estimate the severity of the symptom with a score from 1 to 7. Patients were treated with auto hemo transfusion (GAE) according to the SIOOT (Scientific Society of Oxygen Ozone Therapy) protocols, twice a week for one month and twice a month as maintenance therapy. No side effects have been found, and 26 patients (72%) achieved a significant improvement (>50% of the symptoms). Ozone therapy is a valid supportive therapy for fatigue in patients with cancer, both during cancer therapy and in a palliative setting without any significant side effects.
Improving Mental Health using Machine Learning to Assist Humans in the Moderation of Forum Posts

This work investigates the potential for the application of machine learning and natural language processing technology in an online application designed to help teenagers talk about their mental health issues. Specifically, we investigate whether automatic classification methods can be applied with sufficient accuracy to assist humans in the moderation of posts and replies to an online forum. Using real data from an existing application, we outline the specific problems of lack of data, class imbalance and multiple rejection reasons. We investigate a number of machine learning architectures including a state-of-the-art transfer learning architecture, BERT, which has performed well elsewhere despite limited training data, due to its use of pre-training on a very large general corpus. Evaluating on real data, we demonstrate that further large performance gains can be made through the use of automatic data augmentation techniques (synonym replacement, synonym insertion, random swap and random deletion). Using a combination of data augmentation and transfer learning, performance of the automatic classification rivals human performance at the task, thus demonstrating the feasibility of deploying these techniques in a live system.
ADDITION OF DULAGLUTIDE FOR A HIGH-DOSE INSULIN REQUIRING PATIENT WITH TYPE 2 DIABETES MELLITUS: A REMARKABLE RESPONSE.

Objective Despite the availability of several new classes of antidiabetic medications, a large proportion of patients with diabetes mellitus fail to achieve optimal glycemic control. Adding glucagon-like peptide-1 receptor agonists (GLP1 RAs) to basal insulin regimens has shown to improve glycemic control in type 2 diabetes mellitus (T2DM). Methods We present a patient with T2DM who had marked improvement in glycemic control accompanied by weight loss and a decrease in insulin requirement after adding weekly dulaglutide to U500 regular insulin. Results A 56-year-old man with T2DM, class III obesity (weight 314 pounds, body mass index 46.4 kg/m2), and hyperlipidemia had uncontrolled glycemia with a hemoglobin A1c (HbA1c) of 9.7% (83 mmol/mol) despite using high-dose insulin therapy and metformin. Physical examination was unremarkable except for obesity. His HbA1c remained high despite increments in insulin dosage up to 400 units per day. A few months after adding dulaglutide to his regimen, the patient's HbA1c declined to 6.3% (45 mmol/mol) despite significant reduction in daily insulin dosage to 20 units (94% decrease), which was accompanied by a 20-pound weight loss. Conclusion The patient had a dramatic decrease in HbA1c, weight, and insulin requirement after treatment with dulaglutide. In the literature we could only find 1 study where a GLP1 RA (liraglutide) was successfully used in 15 patients receiving U500 insulin (average dose 197 ± 72 units/day). However, their reductions in weight and HbA1c were markedly less than observed in our patient. GLP1 RAs should be considered in patients with T2DM who require high-dose insulin therapy.
Identification of Left Ventricular Ejection Fraction less than or equal to 40 percent by Quantitative Troponin T measurement after ST Elevation Myocardial Infarction

INTRODUCTION: Myocardial infarction is a syndrome arising from injury to the myocardial tissues due to imbalance in the perfusion and demand with the major cause being coronary atherosclerosis with a superimposed coronary thrombus. When a myocardial injury occurs, various enzymes are being released in to the blood after two hours and they are detectable in the blood by various assays. Troponins can detect very small degrees of myocardial damage. Troponin T has practical advantages over CK-MB in the assessment of left ventricular ejection fraction. Its measurement directly correlates with the infarct size which is inversely proportional to the ejection fraction. AIMS AND OBJECTIVES: To identify left ventricular ejection fraction of less than or equal to 40percent by quantitatie Troponin T measurement after first episode of ST elevation Myocardial Infarction. MATERIALS AND METHODS: This study was conducted in Government Royapettah Hospital in the department of medicine between July and December 2012.Fifty consecutive patients with first attack of ST elevation of myocardial infarction were selected and observed. Troponin T levels are measured 12 to 48 hours after admission so as to obtain its peak value. Two dimensional Echocardiography was done 3 to 4 weeks later and ejection fraction was measured. The relationship between left ventricular ejection fraction and troponinT concentration was studied using spearman’s correlation coefficient. OBSERVATION AND RESULTS: There was a strong negative correlation between the left ventricular ejection fraction and Troponin T levels. Spearman’s rank correlation coefficient was -0.874 with p values <0.0001.
To Study the Association of Free Insulin Levels, Obesity Markers & Lipid Profile Parameters in Newly Diagnosed Patients of Type 2 Diabetes Mellitus in Tertiary Care Centre of Kumaon Region

1 Assistant Professor, 2 Tutor, 3 PG JR, 4 Associate Professor 1,2,3,4 Department of Biochemistry, Govt. Medical College, Haldwani, India Corresponding Author Sangeeta Singh Email: singh_4647@yahoo.co.in Abstract Diabetes Mellitus is the commonest metabolic abnormality in the world. Type 2 diabetes the commonest form of diabetes constitutes nearly 90% of diabetic population in any country. Type 2 diabetes mellitus is characterized by impaired insulin secretion, insulin resistance, excessive hepatic glucose production, and abnormal fat metabolism. Obesity, particularly visceral or central (as evidenced by the hip-waist ratio), is very common in type 2 diabetes mellitus. Obesity is always associated with increase in plasma triglycerides. Dyslipidemia includes hypertriglyceridemia, reduced HDL cholesterol, and increased numbers of small, dense LDL particles. The present was therefore planned to study the correlation between markers of obesity, lipid profile & insulin resistance in newly diagnosed patients of type 2 Diabetes mellitus. Materials & Methods: 100 newly diagnosed patients of Type 2 DM were taken as cases. Healthy age & sex matched 100 subjects were included in control group. Results: In this study 37 patients of DM were overweight and 19 were obese. All the female patients showed waist hip ratio (WHR) >0.85 and 33 males out of 43 had WHR >0.90. Mean waist circumference in diabetic cases were significantly raised when compared with healthy controls. The mean level of Triglyceride & VLDLc in diabetic cases was found to be significantly raised when compared with normal subjects. The mean level of ApoB was found to be significantly elevated in diabetics as compared with controls. in this study the levels of HbA1c & serum free insulin were also significantly raised in diabetic cases as compared to normal subjects. Conclusion: This study showed that newly diagnosed diabetic patients have high incidence of obesity, insulin resistance and dyslipidemias, which predisposed them to metabolic syndrome. Significantly high levels of HbA1c in newly diagnosed DM suggests its utility as the predictor of future risk for metabolic syndrome.
Prevalence of Methicillin-resistant Staphylococcus Aureus in Saudi Arabia Revisited: A Meta-analysis

The dramatic increase in the prevalence of methicillin-resistantStaphylococcus aureusas a source of nosocomial and community-associated infections in Saudi Arabia has attracted the attention of many researchers and public health workers. Hence, the aim of this meta-analysis is to assess the extent of the problem in Saudi Arabia at large.PubMed database was searched for articles about the prevalence of MRSA in Saudi Arabia, and the relevant data from all eligible studies were analyzed to assess the overall prevalence rate by ProMeta3.Seven articles were included in this meta-analysis with the sample size of 8433 individual. The overall prevalence of MRSA was 38% (95% CI: 28 – 50). The prevalence of MRSA according to the region was 32% (95%CI: 21 – 46) for the central region and 42% (95% CI: 33 – 52) for the western region.The findings of this study indicate that the overall prevalence of MRSA in Saudi Arabia is relatively high, with the western region showing the highest prevalence rates, which necessitates the urgent implementation of preventive and educative strategies.
Does Hydrotherapy Improve Health-related Quality of Life (HR-QoL) in Adult Men and Women with Multiple Sclerosis (MS)?

Objective: The objective of this selective EBM review is to determine whether or not hydrotherapy improves health-related quality of life (HR-QoL) in adult men and women with multiple sclerosis (MS). Study Design: Review of three randomized controlled trials (RCTs) published between 2012current, all in the English language. Data Sources: Three randomized controlled trials (RCTs), all of which evaluate the effectiveness of hydrotherapy compared to a control group that was asked either not to change their exercise habits or to participate in land-based activities. All studies were found using PubMed and Embase. Outcomes Measured: Each of the three articles analyzed the effects of hydrotherapy on improving health-related quality of life. The Short form-36 (SF-36), Multiple Sclerosis Quality of Life-54 (MSQOL-54), and Multiple Sclerosis Impact Scale-29 (MSIS-29) were the questionnaires used to measure HR-QoL. Results: The studies by Castro-Sanchez et al. and Kargarfard et al. found that hydrotherapy significantly improved HR-QoL in adult MS patients compared to the control group. The study by Bansi et al. was inconclusive because HR-QoL improved both in the experimental and control group, with no significant difference between the two. Conclusions: Hydrotherapy was shown to improve HR-QoL in all three studies. However, in one study, HR-QoL improved independent of the therapy used, with no significant difference between the hydrotherapy and land-based exercise groups. Therefore, evidence is inconclusive.
Designing and Implementing Medicaid Disease and Care Management Programs: A User's Guide

The findings and conclusions in this document are those of the authors, who are responsible for its content, and do not necessarily represent the views of AHRQ. No statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services. This Guide could not have been produced without the assistance of a number of people. AHRQ and The Lewin Group would especially like to acknowledge the AHRQ Medicaid Care Management Learning Network States for their contributions to the Guide. Through participation in the AHRQ Medicaid Care Management Learning Network, the 13 participating States provided much of the Guide's content. In addition, many of the States' participants and other individuals provided feedback and content. In particular, we would like to acknowledge the time and effort of the following individuals: This document is in the public domain and may be used and reprinted without permission except those copyrighted materials noted for which further reproduction is prohibited without the specific permission of copyright holders.
Identifying Significant Antipsychotic-Related Side Effects in Patients on a Community Psychiatric Rehabilitation Unit-A Feasibility Study of The Glasgow Antipsychotic Side-Effect Scale (GASS)

Antipsychotic side-effects are common and are an important determinant of non-adherence and consequent relapse. Most rating scales for the identification of these are lengthy and complicated. This report reviews the medical literature on the Glasgow antipsychotic side-effect scale (GASS)-a brief and validated rating scale to measure the unwanted effects of antipsychotics. We administered the GASS to fourteen in-patients in a United Kingdombased Community Psychiatric Rehabilitation Unit. The objective was to establish the utility of the GASS in this setting and to make recommendations on how this tool could be used in clinical practice to improve adherence to antipsychotic medication.
Ochraceocephala foeniculi gen. et sp. nov., a new pathogen causing crown rot of fennel in Italy

Abstract A new disease of fennel is described from Sicily (southern Italy). Surveys of the disease and sampling were conducted during spring 2017 and 2018 in Adrano and Bronte municipalities (Catania province) where this crop is widely cultivated. Isolations from the margin of symptomatic tissues resulted in fungal colonies with the same morphology. Pathogenicity tests with one isolate of the fungus on 6-month-old plants of fennel reproduced similar symptoms to those observed in nature. Inoculation experiments to assess the susceptibility of six different fennel cultivars to infection by the pathogen showed that the cultivars ‘Narciso’, ‘Apollo’, and ‘Pompeo’ were more susceptible than ‘Aurelio’, ‘Archimede’, and ‘Pegaso’. Phylogenetic analyses based on a matrix of the internal transcribed spacer (ITS), the large subunit (LSU), and the small subunit (SSU) rDNA regions revealed that the isolates represent a new genus and species within the Leptosphaeriaceae, which is here described as Ochraceocephala foeniculi gen. et sp. nov. This study improves the understanding of this new fennel disease, but further studies are needed for planning effective disease management strategies. According to the results of the phylogenetic analyses, Subplenodomus iridicola is transferred to the genus Alloleptosphaeria and Acicuseptoria rumicis to Paraleptosphaeria.
Validation of an educational tool on healthy eating for schoolchildren

ABSTRACT Objective The purpose of this study was to validate the card game The Enigma of the Pyramid about healthy eating, using judges (expert) for the validation of content and design; and the target population (students from the 4th and 5th grades, aged 9-10 years) for the semantic validation (pilot test). Methods The Item-Level Content Validity Index was used to verify the degree of agreement among the experts’ opinions, item by item; and the Scale Level Content Validity Index to determine the arithmetic mean of the proportion of items that receive judgments of “non-disagreement” by the judges. The item that obtained Item-Level Content Validity Index greater or equal to 0.80 and Scale Level Content Validity Index greater or equal to 0.90 was considered validated, which was the coefficient of validity. The binominal test was used to select the items that should be revised/modified, using the p-value of ratio (reject H0 if p≤0.8). Items were validated at significance level of ≤0.05. Results Twenty-two judges and 12 schoolchildren participated in the study. Of the 23 items of the card game, nine were selected for review/modification, of which five were from the language component and four from the suitability component for the target population. Conclusion Once the modifications were made, they were all approved by all participating students, making this educational tool on healthy eating habits available for use with the student population.
Acetyl-11-keto-β-boswellic Acid Inhibits Precancerous Breast Lesion MCF-10AT Cells via Regulation of LINC00707/miR-206 that Reduces Estrogen Receptor-α

Purpose Acetyl-11-keto-β-boswellic acid (AKBA) has therapeutic effects on a range of diseases, including tumours. lncRNAs, as competing endogenous RNAs (ceRNAs), can interact with miRNAs to regulate the expression of target genes, which can affect the development of tumors. Here, we examined the effects of AKBA on breast precancerous lesions MCF-10AT cells. Methods The expression profiles of breast cancer (BC) tissue were collated from The Cancer Genome Atlas (TCGA), and the lncRNA-miRNA-mRNA ceRNA network was constructed. AKBA targets were predicted by network pharmacology. The expression of long intergenic nonprotein-coding RNA 707 (LINC00707), miR-206 and ER-α was determined by qRT-PCR. Cell viability, apoptosis and cycle were assessed by CCK-8 and flow cytometry. Protein levels were measured by Western blotting. Results A total of 3205 differentially expressed mRNAs, 104 miRNAs, and 605 lncRNAs were identified. The ceRNA network consisting of 9 lncRNAs, 15 miRNAs and 82 mRNAs was constructed. We found that LINC00707 was up-regulated and miR-206 was down-regulated in MCF-10AT cells. Transfected si-LINC00707 could inhibit cell proliferation, induce cell apoptosis and cycle arrest of MCF-10AT cells. In addition, network pharmacology predicted that AKBA may regulate the ESR1 in the treatment of BC. Our research demonstrated that AKBA could induce cell apoptosis and G1-phase arrest and inhibit ER-α expression via LINC00707/miR-206 in MCF-10AT cells. Conclusion AKBA inhibited MCF-10AT cells via regulation of LINC00707/miR-206 that reduces ER-α.