Miracle-dz/UniFAR-FTUs huggingface dataset:
Biological Control-Parasitoids and Predators Biological Control of Hemlock Woolly Adelgid: Implications of Adult Emergence Patterns of Two Leucopis spp. (Diptera: Chamaemyiidae) and Laricobius nigrinus (Coleoptera: Derodontidae) Larval Drop

The hemlock woolly adelgid (Hemiptera: Adelgidae Adelges tsugae Annand) poses a serious threat to hemlocks in eastern North America, and ongoing research is focused on the identification and development of biological controls to protect and manage hemlock resources. Three predators native to the Pacific Northwest of North America that have been the focus of much research are Leucopis argenticollis (Zetterstedt), Leucopis piniperda (Malloch) (Diptera: Chamaemyiidae), and Laricobius nigrinus (Fender) (Coleoptera: Derodontidae). This study addresses the knowledge gap of adult Leucopis spp. emergence patterns, with comparisons to the timing of larval La. nigrinus drop for pupation. Adult Leucopis spp. emergence was observed in the lab from field-collected, adelgid-infested foliage from Washington state in 2019 and 2020. Adult Leucopis spp. were collected daily as they emerged from foliage collections and identified to species using morphological features; a subset was validated using DNA barcoding. Accumulated heating degree days were calculated to compare a standardized emergence timing across collections made at different locations and temperature regimes. The abundance of the two Leucopis spp. and of the combined Leucopis spp. and La. nigrinus varied among sites and years, and no species was consistently more abundant than the other. Evaluations of seasonal emergence trends of the three species determine the predator complex behaves in a temporally stratified and predictable way. Emergence of adult Le. argenticollis was observed first, followed by La. nigrinus larval drop, with Le. piniperda emerging at the end of larval drop, and finally a second emergence of Le. argenticollis.
Dysfunctional energy metabolisms in fibromyalgia compared with healthy subjects

This study aimed to investigate the levels of creatine (Cr) metabolites in the anterior cingulate cortex (ACC), thalamus, and insula of patients with fibromyalgia (FM) using proton magnetic resonance spectroscopy (MRS). The levels of Cr and phosphocreatine (PCr) relative to total Cr (tCr), which includes Cr and PCr, in the ACC, thalamus, and insula were determined using MRS in 12 patients with FM and in 13 healthy controls. The FM group had lower levels of PCr/tCr in the ACC and right insula compared to healthy controls. There was a negative correlation between Cr/tCr in the ACC and total pain levels (McGill Pain Questionnaire-Total; r = −0.579, p = 0.049) and between Cr/tCr in the left insula and affective pain levels (McGill Pain Questionnaire-Affective; r = −0.638, p = 0.047) in patients with FM. In addition, there were negative correlations between stress levels (Stress Response Inventory) and Cr/tCr in the right (r = −0.780, p = 0.005) and left thalamus (r = −0.740, p = 0.006), as well as in the right insula (r = −0.631, p = 0.028) in patients with FM. There were negative correlations between symptom levels of post-traumatic stress disorder (PTSD; PTSD checklist) and Cr/tCr in the right (r = −0.783, p = 0.004) and left thalamus (r = −0.642, p = 0.024) of patients with FM. These findings are paramount to understanding the decisive pathologies related to brain energy metabolism in patients with FM.
Nurses’ challenges, concerns and unfair requirements during the COVID-19 outbreak

Background During disease outbreaks, nurses express concerns regarding the organizational and social support required to manage role conflicts. Objectives The study examined concerns, threats, and attitudes relating to care provision during the COVID-19 outbreak among nurses in Israel. Design A 53-item questionnaire was designed for this research, including four open-ended questions. The article used a qualitative research to analyze the responses to the open-ended questions and their association with responses to the close-ended ones. Participants and research context In all, 231 registered nurses and fourth-year nursing students throughout the whole country. The questionnaire was delivered in nursing Facebook and WhatsApp groups and through snowball sampling. Ethical considerations The research was pre-approved by the Ethics Committee at the researchers’ university. Results Nurses mostly referred to personal risk, followed by dilemmas regarding care provision. On average, 38.6% of quotations stated that during the pandemic, nurses are not asked to perform unfair duties. Nurses discussed activities and requirements that impact their personal and familial safety, their relationship with employer, organization or the state, and their duty to providing care. Other than fear of contraction, respondents’ most frequent themes of concerns were related to work condition and patients’ interests, inter-collegiate relationships, and uncertainty and worries about the future. Respondents’ ethical dilemmas mostly referred to clinical questions, providing care without adequate equipment or managerial support, and in conditions of uncertainty and increased risk. Discussion Nurses raise important issues concerning their relationships with employers and family members, and significant insights regarding the pandemic and their revised responsibilities and definition of work. They raise serious concerns regarding their rights at work and their standing for them. Conclusions Health managers should find ways to enhance the ethical climate and institutional support to enable a better work-life balance in times of pandemic and support nurses’ working needs and labor rights.
TIMP1 Triggers Neutrophil Extracellular Trap Formation in Pancreatic Cancer

These findings highlight the prognostic relevance of TIMP1 and neutrophil extracellular traps in highly lethal pancreatic cancer, where a noncanonical TIMP1/CD63/ERK signaling axis induces NET formation. Tumor-derived protein tissue inhibitor of metalloproteinases-1 (TIMP1) correlates with poor prognosis in many cancers, including highly lethal pancreatic ductal adenocarcinoma (PDAC). The noncanonical signaling activity of TIMP1 is emerging as one basis for its contribution to cancer progression. However, TIMP1–triggered progression-related biological processes are largely unknown. Formation of neutrophil extracellular traps (NET) in the tumor microenvironment is known to drive progression of PDAC, but factors or molecular mechanisms initiating NET formation in PDAC remain elusive. In this study, gene-set enrichment analysis of a human PDAC proteome dataset revealed that TIMP1 protein expression most prominently correlates with neutrophil activation in patient-derived tumor tissues. TIMP1 directly triggered formation of NETs in primary human neutrophils, which was dependent on the interaction of TIMP1 with its receptor CD63 and subsequent ERK signaling. In genetically engineered PDAC-bearing mice, TIMP1 significantly contributed to NET formation in tumors, and abrogation of TIMP1 or NETs prolonged survival. In patient-derived PDAC tumors, NETs predominantly colocalized with areas of elevated TIMP1 expression. Furthermore, TIMP1 plasma levels correlated with DNA-bound myeloperoxidase, a NET marker, in the blood of patients with PDAC. A combination of plasma levels of TIMP1 and NETs with the clinically established marker CA19–9 allowed improved identification of prognostically distinct PDAC patient subgroups. These observations may have a broader impact, because elevated systemic levels of TIMP1 are associated with the progression of a wide range of neutrophil-involved inflammatory diseases. Significance: These findings highlight the prognostic relevance of TIMP1 and neutrophil extracellular traps in highly lethal pancreatic cancer, where a noncanonical TIMP1/CD63/ERK signaling axis induces NET formation. Graphical Abstract: http://cancerres.aacrjournals. org/content/canres/81/13/3568/F1.large. jpg. Graphical Abstract:
Appropriate Systemic Therapy Dosing for Obese Adult Patients With Cancer: ASCO Guideline Update

PURPOSE To provide recommendations for appropriate dosing of systemic antineoplastic agents in obese adults with cancer. METHODS A systematic review of the literature collected evidence regarding dosing of chemotherapy, immunotherapy, and targeted therapies in obese adults with cancer. PubMed and the Cochrane Library were searched for randomized controlled trials, meta-analyses, or cohort studies published from November 1, 2010, through March 27, 2020. ASCO convened an Expert Panel to review the evidence and formulate recommendations. RESULTS Sixty studies, primarily retrospective, were included in the review. Overall, the evidence supported previous findings that obese adult patients tolerate full, body-size–based dosing of chemotherapy as well as nonobese patients. Fewer studies have addressed the dosing of targeted therapies and immunotherapies in relation to safety and efficacy in obese patients. RECOMMENDATIONS The Panel continues to recommend that full, weight-based cytotoxic chemotherapy doses be used to treat obese adults with cancer. New to this version of the guideline, the Panel also recommends that full, approved doses of immunotherapy and targeted therapies be offered to obese adults with cancer. In the event of toxicity, the consensus of the Panel is that dose modifications of systemic antineoplastic therapies should be handled similarly for obese and nonobese patients. Important areas for future research include the impact of sarcopenia and other measures of body composition on optimal antineoplastic dosing, and more customized dosing based on pharmacokinetic or pharmacogenetic factors. Additional information is available at www.asco. org/supportive-care-guidelines.
Long-Term Effects of a Comprehensive Police Suicide Prevention Program

Abstract. Background: Mishara and Martin (2012) reported decreases in suicides 12 years after implementation of a police suicide prevention program. Aims: We aimed to determine whether suicide decreases were sustained 10 years later. Method: We examined coroners’ investigations of police deaths from 2009 through 2018. Results: From 2009 to 2018, Montreal suicide rates increased but this was not significantly different from the previous 12 years and the rate for other Quebec police remained significantly higher than Montreal (p < .006). The 22-year Montreal postprogram rate was significantly lower than the preprogram rate (p < .002), and the 22-year rate for other police during the same years was not significantly different from earlier. Limitations: Uncontrolled factors may have influenced the rates, including the 11% increase in women in the Montreal police. The observed mean aging of the Montreal police personnel would have been expected to bias toward finding increases in suicides. However, the maintenance of decreases in suicide rates was observed. Conclusion: The decrease in suicides observed 12 years after the program was sustained for another 10 years, and appears related to the program. Rates for comparable police remained higher. A continuing comprehensive suicide prevention program tailored to the context may reduce suicides for extended time periods.
Arts, Culture, and Creativity as a Strategy for Countering the Negative Social Impacts of Immigration Stress and Gentrification

Background. This article looks at the role that arts, culture, and creativity play in promoting social cohesion and community well-being. It presents research on the role that a community arts center plays in an ethnic enclave that is under stress of immigration and gentrification. Method. An academic–community research partnership conducted this research. A mixed-methods approach was used. Twenty-four interviews were conducted with stakeholders (including community leaders, neighborhood residents, and business owners). Surveys (n = 102) were done of community members and those who participate in the Center activities. Results. Interviewees and survey respondents point to the importance of the ethnic enclave as a close-knot community that helps to foster a sense of belonging, security, and cultural identity. Arts, culture, and creativity plays a role in maintaining this sense of social cohesion, despite the threat of gentrification. Engagement in the arts and creative practice are important for buffering the stress of immigration. Discussion. The center has an important role as a critical cultural, civic, and creative space for the neighborhood and the broader community who sees the ethnic enclave as their cultural home.
Three‐dimensional gradient and spin‐echo readout for time‐encoded pseudo‐continuous arterial spin labeling: Influence of segmentation factor and flow compensation

To monitor the complete passage of the labeled blood through the vascular tree into tissue and improve the quantification of ASL maps, we evaluated the effect of 3D gradient and spin‐echo (GRASE) readout segments on temporal SNR (tSNR) and image blurriness for time‐encoded pseudo‐continuous arterial spin labeling and the effect of flow‐compensation gradients on the presence of intravascular signal.
The morning after the night before: Alcohol-induced blackouts impair next day recall in sober young adults

Binge-drinking in adolescents and young adults is a widespread problem, however, an often unreported consequence of binge-drinking behaviour is an alcohol-induced memory blackout (MBO). An MBO is a transient amnesic event resulting from rapid, excessive alcohol consumption. Here, we examine the short-term impact of an alcohol-induced MBO event (testing < 20 hours after blackout) on memory performance in people who have experienced a high volume of MBOs. In addition, we aimed to test the hypothesis that people who experience a high volume of MBOs may have poorer recall than non-blackout controls in either sober or intoxicated states. Three episodic memory paradigms consisting of free recall, serial recall, and depth of encoding tasks, were conducted by a group of alcohol drinkers who had never experienced a memory blackout, and those who reported at least 9 in the preceding 12-months. Studies were completed sober and after alcohol by all participants, and sober but after blackout by the experimental group. Accuracy of recall was assessed with linear mixed effects modelling for all experiments and conditions. Recall rate both before and after alcohol consumption was similar between groups, with poorer recall after drinking alcohol by all participants in all three studies. After blackout, MBO participants showed no significant improvement from their intoxicated state in serial recall and depth of encoding tasks, but an improvement in free recall. Further analysis of these findings revealed that 10 out of 23 participants showed significantly impaired performance after blackout during free recall, extending up to 17 participants in serial recall. In general, alcohol reduced recall rate in both blackout and control participants similarly, but recall following MBO remained poor. Our evidence suggests that alcohol-induced blackouts impair memory functioning the next day, and future research should establish the duration of deficits after an acute alcohol-induced blackout episode.
Development and Evaluation of Donut Matrix Tablets of Baclofen Using Mucilaginous Polymer from Portulaca oleracea Linn.

The aim of this work was to prepare and evaluate novel mucoadhesive donut-shaped tablets of baclofen for the gastric retentive delivery of the drug. Drug release from donut-shaped tablets followed approximately zero order, owing to constant surface areas of drug release, caused by the special donut geometry. Mucilaginous polymeric extract from Portulaca oleracea Linn. leaves was used as a novel mucoadhesive agent for gastric retention purposes. This mucilage displayed superior gastric retentive and drug release properties during in vitro dissolution and ex vivo permeation compared to synthetic mucoadhesives such as Carbopol 940 (a cross-linked polyacrylate polymer) and sodium carboxymethylcellulose.
Hydrodynamical effect of parallelly swimming fish using computational fluid dynamics method

Fish form schools because of many possible reasons. However, the hydrodynamic mechanism whereby the energy efficiency of fish schools is improved still remains unclear. There are limited examples of fish models based on actual swimming movements using simulation, and the movements in existing models are simple. Therefore, in this study, we analyzed the swimming behavior of Biwa salmon (Oncorhynchus sp., a salmonid fish) using image analyses and formulated its swimming motion. Moreover, computational fluid dynamics analysis was carried out using the formulated swimming motion to determine the fluid force acting on the fish body model with real fish swimming motion. The swimming efficiency of the fish model under parallel swimming was obtained from the calculated surrounding fluid force and compared for different neighboring distances. The flow field around the fish model was also examined. The swimming efficiency of two fish models swimming parallelly was improved by approximately 10% when they were separated by a distance of 0.4L, where L is the total length of the model. In addition, the flow field behind the fish body was examined under both inphase and antiphase conditions and at inter-individual distances of 0.8L and 1.2L. The apparent flow speed in the distance range of 0.5–2.0L from the midpoint of the snouts of the two individuals was lower than the swimming speed. The pressure distribution on the fish model showed an elevated pressure at the caudal fin. Interestingly, we obtained an isopleth map similar to that of a caudal peduncle. To avoid a negative thrust, the aft part of the body must be thin, as shown in the isopleth map obtained in this study.
Attempting to combine factors of E times in a new research comprehensive chemistry experiment

A compositive experiment was proposed.The novel method for synthesis nanocrystals of Znic Oxide was studied in the experiment.Zinc carbonate hydroxide precursor was synthesised via solid state chemistry reaction under room temperature,in which powder of Na_(2)CO_(3) containing PEG-400 and powder of ZnSO_(4) 7H_(2)O were used as start materals. Nanocystals of zinc oxide was gotten when the precursor was pyrolyzed at high temperature.Basis of the application of uniform experimental design as well as data mining technology,the influence of multiple factors on the synthesis of zinc oxide crystals were investigated.The characteristics results of XRD indicated that the product was ZnO with size of 24 nm.In the experiment,not only multiple knowledge points of chemistry but also that of data mining technology were synthesized to achieve combination between chemistry experiment and data mining technology.
Effect of potassium, sulfur, boron and molybdenum fertilization on alfalfa production and herbage composition

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Nitrogen absorption and utilization differences among wheat varieties for different end uses

Grain yield and quality could be efficiently regulated by varieties, producing station and cultural techniques. Based on the characteristics of nitrogen absorption and accumulation in different types of wheat, research focus is now putting on achieving higher yield, increasing nitrogen application efficiency, improving grain quality, producing less pollution and reducing production cost. The differences of nitrogen absorption and utilization among three wheat varieties for different end uses were studied in field experiments in Yangzhou from 2000 to 2002. The main treatments included three typical varieties: Wanmai38 (strong-gluten), Yangmai10 (medium-gluten) and Ningmai 9 (weak-gluten). The sub-treatments included two levels of fertilizer N application amount: N 180 and 240 (kg/hm~2). During the growth period the total amount of P and K application was 108 (kg/hm~2) (P_2O_5) and 108 (kg/hm~2) (K_2O), respectively, half of which was used as basal fertilizer and the rest as topdressing fertilizer when the remaining leaf number was 3.5. The results showed that (nitrogen) content in plant and grains of strong-gluten wheat Wanmai 38 at maturity was the highest among three varieties. Plant nitrogen accumulation amount of Wanmai 38 was the highest,but grain nitrogen accumulation amount of Yangmai 10 was the highest. The ratio of nitrogen accumulation amount at different stages to total was different among (different) varieties. For weak-gluten wheat Ningmai 9, it was higher than the others from seeding stage to elongation stage, but for strong-gluten wheat Wanmai 38, it was the highest from anthesis to maturity. To produce 100 kg of grains,different amount of N would be absorbed in wheat varieties for different end uses.
High-intensity exergaming for improved cardiorespiratory fitness: A randomised, controlled trial

ABSTRACT Exergaming has been proposed as a promising alternative to traditional endurance training since many experience exergaming as more enjoyable. Therefore, the aim of this trial was to determine the exergaming-induced effect on cardiorespiratory fitness. This parallel-group randomised controlled trial, investigated the effects of regular exergaming among healthy adults (aged ≥ 18 years) who were not endurance-trained. Participants allocated to the exergaming group (n = 13) used the Playpulse exergaming platform for a minimum of 45 min twice weekly for eight weeks, whereas the control group (n = 17) received no intervention. The primary outcome measure was the between-group difference in peak oxygen uptake (V̇O2peak) after the intervention. V̇O2peak increased significantly from baseline (43.9 [SD 7.0]) to after the intervention (45.3 [SD 8.2] mL kg−1 min−1) in the exergaming group, compared to the control group (42.4 [SD 7.0] to 42.0 [SD 5.7] mL·kg−1·min−1) with a between-group difference of 2.1 mL kg−1 min−1 (95% CI: 0.2–4.1; p = 0.04). The average score on the Feeling Scale reported during exergaming was 3.4 (95% CI 3.2–3.6), with 3 being “good” and 5 “very good” and was not related to the participants’ exergaming skills. There were no adverse events during this trial. Two weekly sessions using the Playpulse exergaming platform can improve V̇O2peak. This finding suggests that exergaming can be an efficient form of endurance training. Furthermore, our findings indicate that participants’ enjoyed exergaming irrespective of exergaming skills. Trial registration: ClinicalTrials.gov identifier: NCT04112329.