Miracle-dz/UniFAR-FTUs huggingface dataset:
Development and Preliminary Pilot Testing of a Peer Support Text Messaging Intervention for HIV-Infected Black Men Who Have Sex With Men

Background: Black men who have sex with men (MSM) are disproportionately infected with HIV and are less well retained along the HIV continuum of care. We report on the feasibility of a peer support text messaging intervention designed to increase retention in HIV care and HIV medication adherence among HIV-infected black men who have sex with men. Methods: Based on formative research, a cell phone app was developed to support a peer-based text messaging intervention. The app allowed the researchers to view text messages sent between mentors and mentees, but did not allow them to view other text messages sent by these phones. Three HIV-infected black men who have sex with men were recruited to serve as volunteer peer mentors. They were trained in motivational techniques, peer support skills, and skills for improving appointment attendance and medication adherence. Mentees (N = 8) received the intervention for 1 month. Mentees completed a postintervention survey and interview. Results: The peer mentor text messaging intervention was feasible. Mentors delivered support in a nonjudgmental, motivational way. However, technical and other implementation problems arose. Some mentees desired more frequent contact with mentors, and mentors reported that other commitments made it difficult at times to be fully engaged. Both mentors and mentees desired more personalized contact (ie, phone calls). Conclusions: A text messaging peer mentor intervention was feasible. Additional research with a larger sample is needed to determine optimal ways to improve mentors' engagement in the intervention and to determine intervention acceptability and efficacy. In future studies, peer support phone calls could be incorporated.
FOCUS ISSUE: CARDIAC RESYNCHRONIZATION THERAPY Fluoroscopically Guided Implantation of Modern Cardiac Resynchronization Devices Radiation Burden to the Patient and Associated Risks

To establish radiation risks for patients undergoing ﬂuoroscopically guided cardiac resyn- chronization device implantation. BACKGROUND Cardiac resynchonization therapy (CRT) may be associated with extended ﬂuoroscopic exposure. METHODS The ﬂuoroscopy time, dose-area product (DAP), exposure parameters, and percentage contribution of the ﬂuoroscopic projections commonly used were recorded in a series of 14 consecutive patients referred for cardiac resynchronization device implantation and compared to corresponding data obtained from a control group of 20 patients who underwent a conventional rhythm device implantation operation. The DAP to peak skin dose, DAP to effective dose, and DAP to gonadal dose conversion factors were determined for biventricular pacing and conventional rhythm device implantation using a humanoid phantom and thermoluminescence dosimetry. RESULTS The mean total ﬂuoroscopy time and DAP values were 35.2 min and 4,765 cGy cm 2 , respectively, for biventricular pacing and 8.2 min and 1,106 cGy cm 2 , respectively, for conventional rhythm device implantation. Patient skin dose from biventricular pacing procedures requiring extended ﬂuoroscopic exposure may exceed threshold dose for the induction of skin effects only if X-ray source-to-skin distance is kept low. The risk values for fatal cancer and severe hereditary disorders, respectively, associated with a typical CRT procedure were 273 per million and 0.2 per million treated patients. CONCLUSIONS Radiation risks associated with ﬂuoroscopically guided CRT procedures may be considerable. Present data may be used for the estimation of patient radiation risks from CRT procedures performed in other institutions. (J Am Coll Cardiol 2005;46:2335–9) © 2005 by the American
TIF‐IA, the factor mediating growth‐dependent control of ribosomal RNA synthesis, is the mammalian homolog of yeast Rrn3p

Cells carefully modulate the rate of rRNA transcription in order to prevent an overinvestment in ribosome synthesis under less favorable nutritional conditions. In mammals, growth‐dependent regulation of RNA polymerase I (Pol I) transcription is mediated by TIF‐IA, an essential initiation factor that is active in extracts from growing but not starved or cycloheximide‐treated mammalian cells. Here we report the molecular cloning and functional characterization of recombinant TIF‐IA, which turns out to be the mammalian homolog of the yeast factor Rrn3p. We demonstrate that TIF‐IA interacts with Pol I in the absence of template DNA, augments Pol I transcription in vivo and rescues transcription in extracts from growth‐arrested cells in vitro.
Negative feedback in information dialogues: identification, classification and problem-solving procedures

This research ? essentially empirical and of a linguistic nature ? takes as its departure point the notion of feedback and the analysis of feedback phenomena in French informative dialogues. Our main concern has been to try to map the theoretical models of dialogue control with the empirical reality of dialogue problems. Supported by the statement of Bunt (1995a) that “understanding dialogue behaviour is central to a theory of dialogue”, our research attempts to arrive at a better understanding of dialogue difficulties and reflects on how to construct an acceptable dialogue model adjusted in the best possible way to this complex reality. There is also a certain comparative perspective as we have been considering different kinds of dialogue data at different stages from human? human dialogues to human? machine dialogues.Our contribution will focus on three aspects:
The obstacle-climbing capability of a pole-climbing robot

A trilateral clamping-wheeled, rod-climbing robot is designed to detect internal steel wire fractures in the cylindrical cable of cable-stayed or suspension bridges. In line with this objective, this study also introduces the climbing principle and ontology structure of this robot (Model-1) and analyzes the static dynamic characteristics of this mechanism. This study also analyzes the obstacle-negotiation capability of the robot. Furthermore, the Model-1 structure was updated to a new climbing mechanism (Model-2) based on analysis results. Then, the optimal angles of the upper and lower supporting arms were obtained by building the static model of the new mechanism. Finally, several simulation experiments were carried out, which demonstrate that Model-2 is superior to Model-1 in terms of obstacle-negotiation capability and satisfies the requirements for suspended cable detection.
Reliability assessment of IGBT modules modeled as systems with correlated components

System modeling of electrical components for Wind Turbine (WT) applications is an important part for the overall WT reliability assessment. The presented approach is an approximate method for Insulated Gate Bipolar Transistor (IGBT) reliability estimation, modeled based on the parallel system configuration. The estimated system reliability by the proposed method is a conservative estimate. Application of the suggested method could be extended for reliability estimation of systems composing of welding joints, bolts, bearings, etc. The reliability model incorporates the correlation between the components in the reliability estimation though limit state functions and mechanical (failure-effect) correlations. The model is based on a physics of failure approach and a linear accumulated damage rule. To account model parameter variabilities, the First Order Reliability Method (FORM) technique was applied for the systems failure functions estimation. It is desired to compare the results with the true system failure function, which is possible to estimate using simulation techniques. Theoretical model development should be applied for the further research. One of the directions for it might be modeling the system based on the Sequential Order Statistics, by considering the failure of the minimum (weakest component) at each loading level. The proposed idea to represent the system by the independent components could also be used for modeling reliability by Sequential Order Statistics.
Control of a DC-AC inverter in a wind energy generation system using T-S fuzzy modeling

The wind generation system treated in this paper is composed of a fixed pitch angle wind turbine followed by a Permanent Magnet Synchronous Generator (PMSG) and power electronic converters AC-DC-AC which are coupled to a DC link. This work deals with the control of the inverter in order to ensure a constant DC link voltage. The control design is based on Takagi Sugeno fuzzy model. Stability analysis of the problem is realized using Lyapunov theorem and H-infinity performance. In order to calculate the controller gains, the problem is treated by means of Linear Matrix Inequality (LMI). Simulation results are carried out using MATLAB/SIMULINK to test the effectiveness of the proposed control algorithm.
Computed tomography-guided radiofrequency ablation of hepatocellular carcinoma: treatment efficacy and complications.

AIM To evaluate the efficacy and complications of computed tomography (CT)-guided radiofrequency ablation (RFA) of unresectable hepatocellular carcinoma (HCC). METHODS A retrospective study of 282 patients (231 males, 51 females, age range: 44-76 years, mean age: 62 years) with HCC (322 lesions) who had been treated by CT-guided RFA over a period of 5 years, was performed. The diameter of the tumors ranged from 1.5 to 5 cm. The tumors were considered as ablated completely, if no viability was found on dual-phase dynamic contrast enhanced CT at 1 month after RFA. The follow-up period ranged from 6 to 68 months (mean 29 months) and included a dual-phase dynamic contrast enhanced CT at 1, 3 and 6 months post-RFA and every 6 months afterwards. Patient outcome was evaluated and the survival and recurrence rates were assessed. Each case was reviewed for short-term and long-term complications. RESULTS The ablation success rate was 87.3% (281/322 HCC nodules), while 41 (12.7%) lesions were managed with repeated RFA because of tumor residue. The survival rates at 1, 2, 3, 4 and 5 years were 94.8%, 86.6%, 73.1%, 64.2% and 51.1%, respectively. A total number of 9 (2.8% per procedure) minor complications occurred. No major complications were observed. During the follow-up period, the local tumour progression rate was 22%, while the recurrence rate of new intrahepatic nodules was 48%. CONCLUSION The results of this study support that RFA is an effective and safe technique for the treatment of unresectable HCC.
Helicobacter Pylori and Gastric Cancer: Clinical Aspects

Objective:Although Helicobacter pylori (H. pylori) is considered as the main etiological factor for gastric cancer, the strategy of screening and treating the oncogenic bacterium is still controversial. The objective was to evaluate the status and progress of the cognition about the relationship between H. pylori infection and gastric cancer from a clinical aspect. Data Sources:The data used in this review were mainly from the PubMed articles published in English from 1984 to 2015. Study Selection:Clinical research articles were selected mainly according to their level of relevance to this topic. Results:Gastric cancer is the fifth most common malignancy and the third leading cause of cancer deaths worldwide. The main etiological factor for gastric cancer is H. pylori infection. About 74.7–89.0% gastric cancer was related to H. pylori infection. Up to date, some regional gastric cancer prevention programs including the detection and treatment of H. pylori infection are under way. Current data obtained from the randomized controlled trials suggest that population-based H. pylori screening and treatment is feasible and cost-effective in preventing gastric cancer; however, a population-based H. pylori eradication campaign would potentially lead to bacterial resistance to the corresponding antibiotics, as well as a negative impact on the normal flora. Conclusions:The important questions of feasibility, program costs, appropriate target groups for intervention, and the potential harm of mass therapy with antibiotics must first be answered before implementing any large-scale program.
TRAIL: A Mechanism of Tumor Surveillance in an Immune Privileged Site1

TRAIL is a recently described member of the TNF superfamily. The ability of TRAIL to induce apoptosis in a large number of tumors has stimulated interest in TRAIL as a tumor therapeutic agent. Although TRAIL mRNA is expressed in a number of tissues, its functional significance to various organs is unknown. Because tumors rarely develop in the eye, we have examined this organ for functional TRAIL expression. Our analysis revealed that TRAIL mRNA and protein are constitutively expressed on numerous ocular structures, including the cornea and retina. More importantly, ocular tissue displays functional TRAIL as determined by in vitro killing of TRAIL-sensitive tumor cell lines. Previous studies have shown that ocular tissue also expresses functional Fas ligand (FasL). To assess the contribution of TRAIL and FasL for tumor cell killing in the eye, cell lines susceptible to both TRAIL and FasL were examined. The results show that ocular tissue kills via either ligand, suggesting a compensatory mechanism between TRAIL and FasL. Collectively, these results provide physiological evidence for ocular TRAIL expression, and suggest a role for this molecule in tumor surveillance in an immune privileged site.
AN IMMUNOHISTOCHEMICAL STUDY OF TAL‐1 PROTEIN EXPRESSION IN LEUKAEMIAS AND LYMPHOMAS WITH A NOVEL MONOCLONAL ANTIBODY, 2TL 242

Fifty formalin fixed, paraffin‐embedded cases of T‐acute lymphoblastic leukaemia (T‐ALL) from 12 bone marrow trephines and 38 lymph nodes were stained with a new monoclonal antibody, 2TL 242, raised against recombinant TAL1 protein. The antibody recognizes TAL‐1 polypeptides of molecular weight 39 and 41 kD (full length). In addition, a variety of other leukaemias and lymphomas were also stained with 2TL 242. Twenty‐four of the 50 cases of T‐ALL showed nuclear positivity, ranging from 10 to 90 per cent of leukaemic cells. A positive staining reaction was nuclear and stippled in pattern. Nuclear staining was not seen in any other type of leukaemia or lymphoma. Five cases of follicular lymphoma showed diffuse cytoplasmic staining of variable intensity. Although some background staining is obtained with this antibody, positive nuclear staining is easily distinguishable. This monoclonal antibody has a potential role in primary diagnosis and in the detection of minimal residual disease in T‐ALL.
Virus-I-Transformed T Cells Expression in Human T Cell Leukemia Regulation of IFN Regulatory Factor 4

IFN regulatory factor (IRF)-4 is a lymphoid/myeloid-restricted member of the IRF transcription factor family that plays an essential role in the homeostasis and function of mature lymphocytes. IRF-4 expression is tightly regulated in resting primary T cells and is transiently induced at the mRNA and protein levels after activation by Ag-mimetic stimuli such as TCR cross-linking or treatment with phorbol ester and calcium ionophore (PMA/ionomycin). However, IRF-4 is constitutively upregulated in human T cell leukemia virus type I (HTLV-I) infected T cells as a direct gene target for the HTLV-I Tax oncoprotein. In this study we demonstrate that chronic IRF-4 expression in HTLV-I-infected T lymphocytes is associated with a leukemic phenotype, and we examine the mechanisms by which continuous production of IRF-4 is achieved in HTLV-I-transformed T cells. IRF-4 expression in HTLV-1-infected cells is driven through activation of the NF- (cid:1) B and NF-AT pathways, resulting in the binding of p50, p65, and c-Rel to the (cid:1) B1 element and p50, c-Rel, and NF-ATp to the CD28RE element within the (cid:2) 617 to (cid:2) 209 region of the IRF-4 promoter. Furthermore, mutation of either the (cid:1) B1 or CD28RE sites blocks Tax-mediated transactivation of the human IRF-4 promoter in T cells. These experiments constitute the ﬁrst detailed analysis of human IRF-4 transcriptional regulation within the context of HTLV-I infection and transformation of CD4 (cid:3) T lymphocytes. The Journal of Immunology, 2002, 169: 3120–3130. of the expression is to the of the 40-kDa HTLV-I-en-coded Tax oncoprotein, a key regulator of cellular and viral gene expression. Tax physically interacts with and modulates the activity of numerous host signaling components and transcription factors, resulting in the induction of regulatory genes during the early stages of HTLV-I infection and transformation (24–26). In this study, we provide the ﬁrst detailed analysis of the regulation of the human IRF-4 gene within the context of HTLV-I infection. Our studies establish a link between IRF-4 expression in HTLV-I-infected cells and the presence of the ATL phenotype. We have characterized several transcriptional regulatory elements within the human IRF-4 promoter that in-teract with NF- (cid:4) B, NF-AT, and stimulating factor 1 (Sp-1) transcription factors to drive IRF-4 production in HTLV-I transformed T-cells.
Synthesis , Crystal Structure and Nonlinear Optical Property of RbHgI 3

Searching for new nonlinear optical (NLO) crystals to be used in the infrared (IR) region is still a challenge. This paper presents the synthesis, crystal structure and properties of a new halide, RbHgI3. Its non-centrosymmetric single crystal can be grown in solution. In its crystal structure, all the polar [HgI4] groups align in such a way that brings a favorable net polarization. The measurement by Kurtz–Perry powder technique indicates that RbHgI3 shows a phase-matchable second harmonic generation (SHG) property seven times stronger than that of KH2PO4 (KDP). RbHgI3 displays excellent transparency in the range of 0.48–25 μm with relatively good thermal stability. The UV absorption implies that this yellow compound’s band gap is about 2.56 eV, close to that of AgGaS2. A preliminary measurement indicates that the laser-induced damage threshold of the crystal is about 28.3 MW/cm2. These preliminary experimental data reveal that RbHgI3 is a new candidate as nonlinear optical material in the infrared region.
Internationalization of the File Transfer Protocol

The File Transfer Protocol, as defined in RFC 959 [RFC959] and RFC 1123 Section 4 [RFC1123], is one of the oldest and widely used protocols on the Internet. The protocol's primary character set, 7 bit ASCII, has served the protocol well through the early growth years of the Internet. However, as the Internet becomes more global, there is a need to support character sets beyond 7 bit ASCII.
Motion sensor accuracy under controlled and free-living conditions.

PURPOSE Two studies were conducted to examine the concurrent accuracy of the Yamax SW-200 (YAM), Omron HJ-105 (OM), and Sportline 330 (SL) pedometers, as well as a CSA accelerometer. METHODS In study 1, motion sensor performance was evaluated against actual (observed) steps taken during 5-min bouts at five different treadmill speeds (54, 67, 80, 94, and 107 m x min) using a two-way repeated measures ANOVA (instrument x speed). Additionally, the direction and magnitude of motion sensor error was examined. In study 2, pedometer performance during 24 h of free-living was evaluated against the steps detected by the CSA criterion. The direction and magnitude of pedometer error was also examined in the free-living condition. RESULTS In study 1, the SL showed significant differences from actual steps taken at all treadmill speeds (P < 0.05). Further, the absolute value of percent error was greatest for the SL at all treadmill speeds. At the slowest treadmill speed (54 m x min), the absolute value of percent error increased for the YAM and OM. In study 2, only the SL detected fewer steps than the CSA criterion (P < 0.05). The YAM demonstrated the lowest absolute value of percent error under free-living conditions. CONCLUSIONS Different brands of motion sensors detect steps differently; therefore, caution must be used when comparing step counts between studies that have employed different brands of motion sensors. Taking into consideration the results of both studies and the initial walking test used for instrument screening purposes, it appears that, of the three pedometers tested, the YAM pedometer is most consistently accurate under both controlled and free-living conditions. Future research must consider presenting motion sensor accuracy in absolute terms so that the magnitude of error is not underestimated.
Purification and biochemical characterization of a putative [6Fe-6S] prismane-cluster-containing protein from Desulfovibrio vulgaris (Hildenborough).

A novel iron-sulfur protein has been isolated from the sulfate-reducing bacterium Desulfovibrio vulgaris (Hildenborough). It is a stable monomeric protein, which has a molecular mass of 52 kDa, as determined by sedimentation-equilibrium centrifugation. Analysis of the metal and acid-labile sulfur content of the protein revealed the presence of 6.3 +/- 0.4 Fe/polypeptide and 6.2 +/- 0.7 S2-/polypeptide. Non-iron transition metals, heme, flavin and selenium were absent. Combining these data with the observation of a very anisotropic S = 1/2 [6Fe-6S]3+ prismane-like EPR signal in the dithionite-reduced protein, we believe that we have encountered the first example of a prismane-cluster-containing protein. The prismane protein has a slightly acidic amino acid composition and isoelectric point (pI = 4.9). The ultraviolet/visible spectrum is relatively featureless (epsilon 280 = 81 mM-1.cm-1, epsilon 400 = 25 mM-1.cm-1, epsilon 400,red = 14 mM-1.cm-1). The shape of the protein is approximately globular (S20.w = 4.18 S). The N-terminal amino acid sequence is MFS/CFQS/C QETAKNTG. Polyclonal antibodies against the protein were raised. Cytoplasmic localization was inferred from subcellular fractionation studies. Cross-reactivity of antibodies against this protein indicated the occurrence of a similar protein in D. vulgaris (Monticello) and Desulfovibrio desulfuricans (ATCC 27774). We have not yet identified a physiological function for the prismane protein despite trials for some relevant enzyme activities.
A Single-Phase Rectifier Having Two Independent Voltage Outputs With Reduced Fundamental Frequency Voltage Ripples

Half-bridge rectifiers are able to provide two voltage outputs, which offers three voltage levels, but the two voltage outputs depend on each other and also on system parameters. Moreover, the two voltage outputs contain large ripples because the currents following through the split capacitors contain significant fundamental-frequency components. In this paper, after analyzing the drawbacks of half-bridge rectifiers in detail, an independently controlled neutral leg is added to conventional half-bridge rectifiers to address these drawbacks. Furthermore, the associated decoupling control strategies are proposed. The rectification leg from the conventional half-bridge rectifier is controlled to maintain the dc-bus voltage and to draw a clean sinusoidal current that is in phase with the supply voltage. The neutral leg is controlled with a PI-repetitive controller to regulate one voltage output and also to provide the current path for any dc and/or fundamental-frequency components. As a result, the two voltage outputs are regulated independently and are robust against system parameters. The output voltage ripples are also reduced, and hence, the required capacitance to achieve the same level of voltage ripples is reduced. Experimental results are provided to validate the performance of the proposed single-phase rectifiers having two independent voltage outputs.