Miracle-dz/UniFAR-FTUs huggingface dataset:
The impact of supplementation on nutritional adequacy of patients following the Royal Prince Alfred Hospital elimination diet

Aim : To assess patients’ food and nutrient intake before and on Royal Prince Alfred Hospital (RPAH) elimination diet, with and without supplementation compared to the Nutrient Reference Values. Method: Prospective patients were contacted a week prior to their RPAH allergy unit appointment. Patients who were prescribed the elimination diet were asked to fill in a patient information form, psychological questionnaires and a four day Weighed Food Record (WFR) at baseline and three weeks into the RPAH elimination diet. All data was analysed using Foodworks and Microsoft Excel and compared to the Nutrient Reference Values. Patients were categorized according to elimination diet (strict, moderate approach), wheat and/or dairy restrictions and supplement use. Results: Thirty-two patients baseline and on elimination diet four day WFRs were analysed. The proportion of patients consuming within Acceptable Macronutrient Distribution Range for carbohydrate increased from 40%-69% and fat increased from 50% to 72%. Supplementation made no difference to folate intake at baseline, but on elimination diet 90% of patients taking a folate supplement met the Estimated Average Requirement compared to 9% without supplements. Patients on the moderate approach met their vitamin A requirements without supplements, but only a third on the strict elimination diet patients met their vitamin A requirements without supplementation. All patients calcium intake was low at baseline. On the elimination diet calcium supplementation in required particularly with those patients restricting their dairy intake. Conclusion: Nutrients most at risk on the elimination diet include calcium, vitamin A and folate. Detailed advice regarding suitable food sources, substitutions and supplementation
Chikungunya Fever During Pregnancy and in Children: An Overview on Clinical and Research Perspectives

Chikungunya fever (CF) is an arboviral disease in worldwide expansion due to the plasti‐ city of its pathogen and vector. Chikungunya virus (CHIKV), a positive-sense, singlestranded RNA alphavirus, is transmitted by Aedes (Stegomyia) aegypti and Aedes albopictus mosquitoes, two hegemonic anthropophilic day-biting mosquitoes capable of colonizing very different environments. This expert review discusses the molecular epidemiology, pathophysiology, clinical features, diagnosis, management, and prevention of CF during pregnancy, infancy, and childhood. Specifically, it will focus not only on the issue and challenges of perinatal mother-to-child transmission of CHIKV, its pathogenesis, and ef‐ fects on neurodevelopment, but also on CHIKV-associated central nervous system dis‐ ease in children, two previously ill-characterized features of the infection.
Selecting Bacteria Candidates for the Bioaugmentation of Activated Sludge to Improve the Aerobic Treatment of Landfill Leachate

In this study, a multifaceted approach for selecting the suitable candidates for bioaugmentation of activated sludge (AS) that supports leachate treatment was used. To determine the exploitation of 10 bacterial strains isolated from the various matrices for inoculating the AS contaminated with the Kalina pond leachate (KPL), their degradative potential was analyzed along with their aptitude to synthesize compounds improving remediation of pollutants in wastewater and ability to incorporate into the AS flocs. Based on their capability to degrade aromatic compounds (primarily catechol, phenol, and cresols) at a concentration of 1 mg/mL and survive in 12.5% of the KPL, Pseudomonas putida OR45a and P. putida KB3 can be considered to be the best candidates for bioaugmentation of the AS among all of the bacteria tested. Genomic analyses of these two strains revealed the presence of the genes encoding enzymes related to the metabolism of aromatic compounds. Additionally, both microorganisms exhibited a high hydrophobic propensity (above 50%) and an ability to produce biosurfactants as well as high resistance to ammonium (above 600 µg/mL) and heavy metals (especially chromium). These properties enable the exploitation of both bacterial strains in the bioremediation of the AS contaminated with the KPL.
Numerical evaluation of passive strategies for nocturnal climate optimization in a greenhouse designed for rose production (Rosa spp.)

In passive plastic greenhouses that do not have heating systems, the phenomenon of thermal inversion occurs, which means that the temperature inside the greenhouse is lower than the outdoor environment; therefore, the plants are exposed to thermal conditions that are unsuitable for production. The aim of this work was to evaluate passive air climatization alternatives seeking to optimize the nocturnal microclimate of a multi-tunnel Gothic greenhouse projected for rose production in Bogota savannah. The experimental approach included the use of a CFD-2D simulation model successfully validated by recording and archive of temperature data in a greenhouse. A total of 24 steady-state simulations were developed that included 3 nighttime temperature values, 2 sky conditions and 4 greenhouse configurations. The results showed that under the clear sky condition there was a thermal inversion with a value of -0.53 and -1.11 °C for the standard night-time greenhouse configuration. The installation of a thermal screen and porous mesh in the fixed roof vents allowed to control the presence of thermal inversion under clear sky conditions and optimizing the indoor temperature value in the greenhouse under cloudy sky conditions.
Targeting the actin polymerisation pathway for improved treatment of glioblastoma

One of the most devastating hallmarks of cancer is invasion, a prerequisite for tumour metastasis. Recently, the concept of migrastatics, a term used for drugs that interfere with cancer cell invasion/migration, has championed the development of drugs targeting the actin polymerisation pathway, as a main driver of cell migration. Targeting this cellular phenomenon offers an opportunity to improve the treatment of invasive and highly migratory tumours such as glioblastoma (GBM) and to better understand the mechanisms controlling glioma cell migration. In this study, a small molecule inhibitor, CCG-1423, was identified that distinctively failed to halt migration. These observations suggest that cells continue to migrate via mesenchymal-amoeboid transition (MAT). Immunofluorescence studies and western blotting supported this novel MAT switch by demonstrating the loss of nuclear MKL1, a regulator of CCN1; a key adhesion and secretory protein in mesenchymal cell migration. MAT induction was confirmed at high resolution by Instant Structured Illumination Microscopy (iSIM) and a newly developed ImageJ plugin allowing identification and quantification of MAT associated features such as lamellipodia or filopodia. This approach allowed for the first time, the detailed characterisation of CCG-1423 effects on MAT in gliomas. Clinical relevance of CCN1 was established by an association with tumour grade including increases in CCN1 concentration detected in matched patient blood samples. CCN1 levels were significantly increased in recurrent patient blood samples in comparison to their primary blood samples, suggesting that CCN1 is a key player in GBM invasion and progression. The presented findings support pharmacological intervention with migrastatics through the development of combination treatments to target both mesenchymal and amoeboid cell migration in GBM management to fully inhibit invasion. In addition, this work has generated compelling evidence that CCN1 is a potential blood biomarker to monitor and potentially predict GBM recurrence earlier, therefore increasing survival rates of this devastating disease.
Lifestyle of Patients With High Blood Pressure in Rural Areas of Jahrom, Iran

Background: Choosing the wrong lifestyle could underlie the occurrence of different diseases including hypertension which is a serious threat to health. Objective: This study examined the lifestyle of patients with hypertension in rural health centers of Jahrom city. Methods: This descriptive cross-sectional study was performed on 80 patients with hypertension who were over 30 years old, in Jahrom in 2013. Data was collected using questionnaires and interviews. The questionnaire consisted of two partsincluding demographic characteristics and behavioral questionnaires reflecting the lifestyle of the study population. Data analysis was performed using the statistical software SPSS19. Results: The mean age of participants was 63.02 ± 14.23 ranging from 30 to 70 years, 30% were male and 70% female. Average years of hypertension was 8.4 ± 5.8. Mean systolic and diastolic blood pressure in patients were 128.39 ± 14.01and 80.96 ± 10.44 respectively. The mean BMI of patients was 24.8 ± 4.6. blood Pressure of 75.53% of patients was above the specified threshold (equal to or greater than 140/90). 7.7% of patients were smokers and 20/5% of them used hookah. 14.1% of the patients had regular physical activity. The most frequent behaviors were following the physician's instructions (61.5%) and taking the medicines regylarly (70.5%) and the least frequent behaviors were having regular physical activity (14.1%) and avoiding the stress (10.9%). Conclusions: The results of this study indicate poor lifestyle and behaviors especially in the field avoiding stress and having physical activity in patients with hypertension. therefore, education and training is necessary for the studied pations to adopt healthy lifestyle.
KSR-BOF: a new and exemplified method (as KSRs method) for image classification

Image classification is very important in pattern recognition and computer vision, where, for integrating final representation, feature pooling methods of the max-pooling, sum-pooling and average-pooling have been widely used. In this study, the authors propose a new method called K -strongest responses (KSRs) on the dictionary atoms for integrating the coding coefficients to generate the final representation that is compared with the previous pooling methods, produces better performance for the image classification task. On the basis of the KSR method, to improve classification accuracy and generate more compact and discriminative final representation, a new framework consisting of two-part KSR and bag-of-features is proposed. To evaluate the performance of the proposed method and framework, they apply it to locality-constrained linear coding, linear distance coding and sparse coding by using two datasets from benchmarks of scene classification: 19-class satellite scene and UC Merced Land. The results show that the coding coefficients integrated by their method and framework are more discriminative than other methods.
What Caused the Extraordinarily Hot 2018 Summer in Korea?

In 2018, heatwaves (HWs), defined as a period of abnormally hot weather with a daily maximum temperature (T_Max) exceeding its 95th percentile threshold for at least 3 consecutive days, were prevalent from June through August, and temperature records exceeded the reference values in many countries over East Asia (EA), including China (CH), Japan (JP), and the Korean Peninsula (KP). Particularly, extreme HWs from July through August lasted for the longest duration of 21.3 days, with T_Max reaching 36.9°C. The highest T_Max recorded since 1907 was 41°C in Hongcheon, located east of Seoul in the KP. Here, we examined the factors that influenced the 2018 HW, and how these relate to the 1994 HW, which was the second longest HW recorded in the KP. The results showed that abnormally strong and northwestward extended anticyclone features observed in July 2018 lasted as a persistent North Pacific anticyclone anomaly until August 2018, centered at the northern KP. These anticyclone features subsequently formed a modon-like blocking, with a cyclonic anomaly in the East China Sea. In August 1994, the North Pacific High (NPH) extended to eastern EA, which broke down the meridional dipole Corresponding author: Kyung-Ja Ha, Center for Climate Physics, Institude for Basic Science and Department of Atmospheric Sciences, Pusan National University, 2, Busandaehakro 63beon-gil, Geumjeonggu, Busan, 46241, South Korea E-mail: kjha@pusan.ac. kr J-stage Advance Published Date: 16 November 2019 Journal of the Meteorological Society of Japan Vol. 98, No. 1 154
On polynomial robustness of flux reconstructions

We deal with the numerical solution of elliptic not necessarily self-adjoint problems. We derive a posteriori upper bound based on the flux reconstruction that can be directly and cheaply evaluated from the original fluxes and we show for one-dimensional problems that local efficiency of the resulting a posteriori error estimators depends on p 1/2 only, where p is the discretization polynomial degree. The theoretical results are verified by numerical experiments.
Venetoclax (Venclexta™) for the treatment of relapsed or refractory chronic lymphocytic leukaemia (CLL) with chromosome 17p deletion

Venetoclax (Venclexta™) is a selective, small-molecule inhibitor of the pro-survival B-cell lymphoma 2 (BCL-2) proteins. Thereby, venetoclax triggers mitochondrial outer membrane permeabilisation and activates caspases. These mechanisms restore the apoptotic ability of malignant cells. Currently, venetoclax is not yet approved in Europe, but it received orphan designation in February 2016 for the treatment of acute myeloid leukaemia patients, who are older than 65 years and who cannot receive standard treatment. In April 2016, the Food and Drug Administration (FDA) licensed venetoclax for the treatment of chronic lymphocytic leukaemia (CLL) patients with del(17p), as determined by a FDA-approved test (Vysis CLL FISH probe kit) and who have received at least one prior therapy. This approval was based on the interim analysis of a single-arm, phase II study (M13-982). In this trial, 107 CLL patients were enrolled to receive a 400 mg daily dose of venetoclax with a priori weekly dose ramp-up schedule over 4–5 weeks. The primary outcome of the study was the proportion of patients achieving an overall response (OR), assessed by an independent review committee. 85 (79.4%, CI 70.5–86.6) patients of the per-protocol population achieved an OR; of whom 8 (8%) patients showed a complete remission (CR) or a CR with incomplete blood recovery of blood counts. Median overall survival (OS), median progression-free survival (PFS) as well as the median duration of overall response (DOR) had not been reached at the time of interim analysis. In regard to safety outcomes, 65% of the per-protocol population experienced treatment-related grade 3–4 AEs (most frequent: neutropenia, infection, anaemia, and thrombocytopenia), another 11% of patients had grade 5 AEs and 17% of patients had died in the study. Venetoclax might be a treatment option for relapsed or refractory CLL patients with del(17p) as it has not been agreed upon any standard care for this indication. Nevertheless, a randomised controlled trial (RCT) will be necessary to compare safety and efficacy outcomes in order to enable the interpretation of the actual treatment effect. In addition, mature data is needed to evaluate the efficacy and safety of venetoclax, also in regard with long-term effects and potential resistant mechanisms.
Participation in Political Protest: Tracing Direct and Indirect Effects of News Usage and Social Interaction

The present article attempts to explain that social media is generally considered as an important source for expanding political protest via survey data obtained from 2628 Iranian youth. Using social media information, it is expected that political discussions within social media may also be expanded, thereby enhancing the willingness to participate in political protest. The results indicate that social media for news usage and the increase in the size of social networks presented in these media increases the willingness to participate in political protest either directly or indirectly and through the strengthening of political discussions. Moreover, using social media for social interactions, although not directly affecting participation in political protest, strengthens political discussions among political protesters.
A semi-supervised attention model for identifying authentic sneakers

To protect consumers and those who manufacture and sell the products they enjoy, it is important to develop convenient tools to help consumers distinguish an authentic product from a counterfeit one. The advancement of deep learning techniques for fine-grained object recognition creates new possibilities for genuine product identification. In this paper, we develop a Semi-Supervised Attention (SSA) model to work in conjunction with a large-scale multiple-source dataset named YSneaker, which consists of sneakers from various brands and their authentication results, to identify authentic sneakers. Specifically, the SSA model has a self-attention structure for different images of a labeled sneaker and a novel prototypical loss is designed to exploit unlabeled data within the data structure. The model draws on the weighted average of the output feature representations, where the weights are determined by an additional shallow neural network. This allows the SSA model to focus on the most important images of a sneaker for use in identification. A unique feature of the SSA model is its ability to take advantage of unlabeled data, which can help to further minimize the intra-class variation for more discriminative feature embedding. To validate the model, we collect a large number of labeled and unlabeled sneaker images and perform extensive experimental studies. The results show that YSneaker together with the proposed SSA architecture can identify authentic sneakers with a high accuracy rate.
Potts model with competing interaction up to the third nearest-neighbour generation on a Cayley tree

It is in our interest to investigate the effect of the third nearest-neighbour binary interaction to the phase diagrams of the Potts model on a Cayley tree. Therefore, we generate and analyse the phase diagrams of the Potts model, considering prolonged competing binary interaction J2 and J3 on the same branch of the Cayley tree up to the third nearest-neighbour generations. We derive the recurrence system of equations while taking into account some ranges of competing parameters. We carry out a numerical procedure by applying several stability conditions and characteristic points into the iteration scheme. For some non-zero parameter J3, we found the additional phases of period 5, 6, 9, and 11, with the ferromagnetic, antiphase, paramagnetic, antiferromagnetic and modulated phase. For the modulated phase, we further study the existence of phases with period larger than 12 by conducting a numerical analysis on the variation of wavevector and Lyapunov exponent.
Multiparametric Magnetic Resonance Image Synthesis using Generative Adversarial Networks

Generative adversarial networks have been shown to alleviate the problem of limited training data for supervised learning problems in medical image computing. However, most generative models for medical images focus on image-to-image translation rather than de novo image synthesis. In many clinical applications, image acquisition is multiparametric, i.e. includes contrast-enchanced or diffusion-weighted imaging. We present a generative adversarial network that synthesizes a sequence of temporally consistent contrast-enhanced breast MR image patches. Performance is evaluated quantitatively using the Fréchet Inception Distance, achieving a minimum FID of 21.03. Moreover, a qualitative human reader test shows that even a radiologist cannot differentiate between real and fake images easily. CCS Concepts • Computing methodologies → Modeling methodologies;
Standing up or standing by: Bystander intervention in cyberbullying on social media

Cyberbullying often happens in the presence of bystanders whose behaviors play a key role in changing dynamics of the situation. To examine the factors influencing cyberbystander likelihood of intervening in cyberbullying on social media, a 2 (degree of cyberbullying severity: high vs low) × 2 (level of interpersonal similarity: high vs low) between-subjects experiment was conducted (N = 132). Results indicated that cyberbystanders’ empathic responses depended on the severity of cyberbullying. The more empathy bystanders felt, the more likely they were to publicly and privately intervene. Moreover, the indirect effect of cyberbullying severity on willingness to intervene through empathy was more pronounced when the interpersonal similarity between victim and cyberbystander was low, rather than it was high.
12 Positive Change and Quality of Time in Daily Life

This chapter focuses on the relationship between "quality" and "time" and how individuals define "time well spent" and use it to bring about optimal experi- ences in their personal and professional lives. In describing our findings, we report on both qualitative and quantitative data collected over five years, from individuals in seven different countries. At the end of the chapter, we discuss how we are using our findings to create applications of our work, as well as some general lessons about how we as individuals might incorporate these findings into our own lives.
Wounding and Insect Feeding Trigger Two Independent MAPK Pathways with Distinct Regulation and Kinetics[OPEN]

Wounding induces the parallel activation of two signaling cascades: a MKK4/5-MPK3/6 module (rapid) and a jasmonic acid-dependent MAP3K14-MKK3-MPK1/2/7/14 module (slow) to restrict insect feeding. Abiotic and biotic factors cause plant wounding and trigger complex short- and long-term responses at the local and systemic levels. These responses are under the control of complex signaling pathways, which are still poorly understood. Here, we show that the rapid activation of clade-A mitogen-activated protein kinases (MAPKs) MPK3 and MPK6 by wounding depends on the upstream MAPK kinases MKK4 and MKK5 but is independent of jasmonic acid (JA) signaling. In addition, this fast module does not control wound-triggered JA accumulation in Arabidopsis (Arabidopsis thaliana), unlike its orthologs in tobacco. We also demonstrate that a second MAPK module, composed of MKK3 and the clade-C MAPKs MPK1/2/7, is activated by wounding in a MKK4/5-independent manner. We provide evidence that the activation of this MKK3-MPK1/2/7 module occurs mainly through wound-induced JA production via the transcriptional regulation of upstream clade-III MAP3Ks, particularly MAP3K14. We show that mkk3 mutant plants are more susceptible to herbivory from larvae of the generalist lepidopteran herbivore Spodoptera littoralis, indicating that the MKK3-MPK1/2/7 module is involved in counteracting insect feeding.