Miracle-dz/UniFAR-FTUs huggingface dataset:
A descriptive cross-sectional study to evaluate the Generic Drug User Fee Act: A boon or loss to the Indian generic pharmaceutical industry

This study embraces the Generic Drug User Fee Act (GDUFA) implication on the Indian generic pharmaceutical industry based on the primary analysis. A sample size of randomly selected 250 employees from the generic industry of India, were the study participants and were provided with a close-ended questionnaire. The survey response is subjected to both descriptive and inferential analyses using the SPSS version 21.0 package. The benefits of GDUFA were greater than the challenges to the Indian pharmaceutical industry are the key findings noted in this study. It was further found that the different challenges faced due to the GDUFA did not alter the attention of the Indian generic industry to the other market significantly. Correspondingly, the statistical outcomes of the respondent’s viewpoints implied that the overall impact of the GDUFA on the return on investments for the Indian pharmaceutical industry was increased. It is inferred that the GDUFA has compelled the pharmaceutical industry of India to be in compliance with the United States Food and Drug Administration all the time. Nevertheless, India remains one of the key exporters of generic drugs for the United States. Fundamentally, the GDUFA has displayed an encouraging influence on the Indian pharma sector.
‘ Goblins left dirt in my birth canal ’ : Perceived Cultural Beliefs on the Causes and Meaning Making among Women with Cervical Cancer in Zimbabwe

This qualitative inquiry sought to understand the meanings that patients with cervical cancer give to their illness as well as their perception of non-medical causes of the condition. An interpretive phenomenological research design was adopted where twelve patients living with cervical cancer attending two medical institutions were purposively sampled on their first visit. The researchers used in-depth interviews to collect information from the participants. Thematic content analysis was used to analyse data. Results revealed the following themes that explain what cancer meant to women: strengthening of their relationship with God, traditional meanings, and the drive to make things right in the present. The perceived causes that were reported by the study participants were centred around witchcraft and contamination by evil creatures. The study has implications for those who offer psychotherapy and counselling for women with cervical cancer in this population.
Crop Modeling Activities at AgMIP-South America Workshop

Data were requested from Brazilian colleagues prior to the August 1-5 Workshop, for the purpose of serving as sentinel sites from which participants could do crop model intercomparisons, model sensitivity to climatic factors (temperature, CO2, rainfall, and N fertilization), and model response to baseline versus climate scenarios. Data on growth, soils, management, and weather were provided by the following groups:
Study on α-relaxation of Permittivity in Biological Tissue Based on Bottcher-Bordewijk Model

Many studies show that low-frequency electromagnetic fields can produce biological effects more obviously. Dielectric properties are not stable in biological system, which changes with external conditions such as temperature, external electric frequency, etc. Understanding the dielectric characteristics of bio-tissues under electromagnetic field is very important for them. This paper introduce the frequency in the famous Bottcher-Bordewijk model to explore the α-relaxation of permittivity in biological tissue, it shows that the new model can meet the experiment result. The new model could lay foundation for studying the relaxation characteristics of other materials.
The Role of Management Control System in ERP Project Implementation

Organizations adopt ERP system to increase the availability of information, have real time information to take decision, maximize the efficiency of business process, increase productivity, and for fast business process etc. When ERP projects implement successfully, it can take the organization to the new heights of profitability, but failure of it can throw the organization out of the markets. In this study, we consider two prospective of control system: first is interactive control system and second is diagnostic control system. These two control systems support to ERP implementation. Interactive control system supports organization change and increase employee motivation towards ERP implementation while diagnostic control system monitors the outcomes. Based on the extant literature review, we try to explore the role of management control system (MCS) in ERP projects implementation in organizations that can enhance the organization performance.
Contribu on Investigating Food Safety Factors that Influence ChildCare Employees ’ Self-Commitment to Perform Safe Food Handling Practices

*Corresponding Author: Phone: (717) 649‐8157 ; E‐mail: jreynolds@niagara.edu ABSTRACT Young children are considered a high risk popula on for foodborne illness. This study aimed to iden fy which food safety culture and social system factors affected childcare food handler’s self‐ commitment to perform safe food handling prac ces in South Carolina licensed center‐based childcare facili es. Results iden fied three factors, manager/coworker support, the ability to speak freely, and communica on from managers to staff, had the highest correla ons with self‐commitment. However, speak freely and communica on were the only factors with sta s cally significant effects on self‐commitment. Conclusions and implica ons of the study are given.
THE MESA 15 kW CW 1 . 3 GHz SOLID STATE POWER AMPLIFIER PROTOTYPE

The Mainz Energy recovering Superconducting Accelerator MESA is a multi-turn energy recovery linac with beam energies in the 100 MeV regime currently designed and build at the Institut für Kernphysik (KPH) of Johannes GutenbergUniversität Mainz. The main accelerator consists of two superconducting Rossendorf type modules, while the injector MAMBO (MilliAMpere BOoster) relies on normal conducting technology. The high power RF system is planned completely in solid state technology. With the high power demands of the normal conducting RF cavities up-to-date transistor technology with increased power density has to be used. A 15 kW CW power amplifier prototype with the new technology has been developed by Sigma Phi Electronics and delivered to KPH. In this paper we will present the results of the performance measurements of the amplifier.
P o S ( M Q W 6 ) 0 7 0 4 U 1630-47 during 2002-2006 outburst activity-Timing analysis

The X-ray transient 4U1630-47 shows regular outbursts with a recurrence period of 600 days since its first detection by Vela-5B in 1969. RXTE/ASM monito r reveals heightened activity during 2002 2004 and in beginning of 2006. During these peri ods, theRXTE/PCA observed the source when it was in different stages of the outburst. De ailed spectral and timing analysis had been carried out with the data. Spectral analysis showed the presence of high temperature states as they were reported by Tomsick et al (2005). Detaile d timing analysis presented in this work revealed that the quasi-periodic oscillations (QPOs) are present only in the high temperature states. The variation of inner disk radius with inner di sk temperature for high temperature states shows a distinct pattern in Tin −Rin plane as compared to the one expected from a standard Shakura-Sunyaev disk. This may possibly indicate the prese nce of a slim disk.
Detecting Microglial Density With Quantitative Multi-Compartment Diffusion MRI

Neuroinflammation plays a central role in the neuropathogenesis of a wide-spectrum of neurologic and psychiatric disease, but current neuroimaging methods to detect and characterize neuroinflammation are limited. We explored the sensitivity of quantitative multi-compartment diffusion MRI, and specifically neurite orientation dispersion and density imaging (NODDI), to detect changes in microglial density in the brain. Monte Carlo simulations of water diffusion using a NODDI acquisition scheme were performed to measure changes in a virtual MRI signal following modeled cellular changes within the extra-neurite space. 12-week-old C57BL/6J male mice (n = 48; 24 control, 24 treated with colony stimulating factor 1 receptor (CSF1R) inhibitor, PLX5622) were sacrificed at 0, 1, 3, and 7 days following withdrawal of CSF1R inhibition and were imaged ex-vivo to obtain measures of the orientation dispersion index (ODI). Following imaging, all brains were immunostained with Iba-1, NeuN, and GFAP for quantitative fluorescence microscopy. Cell populations were calculated with the ImageJ particle analyzer tool; correlation between microglial density and mean ODI values were calculated with Kendall's tau. Monte Carlo simulations demonstrate the sensitivity and positive correlation of ODI to increased occupancy in the extra-neurite space. Commensurate with our simulation data, ex-vivo NODDI imaging demonstrates an increase in ODI as microglia repopulate the brain following the withdrawal of CSF1R inhibition. Quantitative immunofluorescence of microglial density reveals that microglial density is positively correlated with ODI and greater hindered diffusion in the extra-neurite space (τ = 0.386, p < 0.05). Our results demonstrate that clinically feasible multi-compartment diffusion weighted imaging techniques such as NODDI are sensitive to microglial density and the cellular changes associated with microglial activation and highlights its potential to improve clinical diagnostic accuracy, patient risk stratification, and therapeutic monitoring of neuroinflammation in neurologic and psychiatric disease.
S Social Recommendation in Dynamic Networks

The research of social recommendation aims at modeling recommender systems more accurately and realistically. The characteristic of social recommendation that is different from the tradition recommender system is the availability of social network, i.e., relational information among the users. Social recommendation focuses on how to utilize user social information to effectively and efficiently compute recommendation results.
Phenolic compounds and their antioxidant activities in Portulaca oleracea L. related to solvent extraction

Our work aims to explore and compare the biological evaluations of Portulaca oleracea leaves by the study of contents in phenolic compounds and antioxidant capacities in order to support scientifically its traditional interest using different solvent for optimization of the extraction. The first part of this study concerns the successive Soxhlet extraction and quantification of total phenols, flavonoid and condensed tannin by the reagent Folin-Ciocaleu, the aluminum trichloride and the vanillin test, respectively. The second part is the study of the antioxidant activities of plant extracts by using two in vitro methods: evolution of total antioxidant capacity and quenching of radical DPPH. The results showed that the methanol fraction is very rich in total polyphenols (13.41 EAG mg / g DM) and exhibits a good antioxidant activity especially for scanning free radicals (IC50 = 78.44 mg/ml). These results are encouraging for the recovery of this species as an excellent medicinal and alimentary plant. * Corresponding Author: Samira Karoune  karounesamira@yahoo.fr International Journal of Biosciences | IJB | ISSN: 2220-6655 (Print), 2222-5234 (Online) http://www.innspub. net Vol. 11, No. 1, p. 147-155, 2017
A UNIFIED APPROACH TO EDGEWORTH EXPANSIONS FOR A GENERAL CLASS OF STATISTICS

This paper is concerned with Edgeworth expansions for a general class of statistics under very weak conditions. Our approach unifies the treatment for both standardized and studentized statistics that have been traditionally studied separately under usually different conditions. These results are then applied to several special classes of well-known statistics: U -statistics, L-statistics, and functions of sample means. Special attention is paid to the studentized statistics. We establish Edgeworth expansions under very weak or minimal moment conditions.
Does the alternative three better

This study constructs the newly developed alternative three Marx, and Zhang 2010) and applies momentum anomaly in international equity market model is able to explain momentum abnormal return model. Although the alphas from the alternative model remain significant, the magnitudes are smaller than those obtained from the Fama countries. Results suggest that the alternative model has French model.
Analysis of the Temporal Component of the Electric Field for the Magnetic Stimulation Technique

The aim of this paper is to analyze the temporal component of the electric field and the activation function, during magnetic stimulation technique. The spatial distribution of the induced electric field for a "multilayer" coil is calculated by superposition the electric field caused by each part of the coil’s winding. The temporal component of the electric field can be separated from the spatial component and may be calculated separately. Assuming that the tissue is purely resistive, this approximation is correct at the operating frequency (f = 2500 (Hz)) of magnetic stimulation. The computation of the temporal distribution of the electric field induced in the tissue during magnetic stimulation and its axial derivative along the nerve fiber (activation function) are performed in transient analysis of the circuit source.
The development and evaluation of the Earth Gravitational Model 2008 ( EGM 2008 )

[1] EGM2008 is a spherical harmonic model of the Earth’s gravitational potential, developed by a least squares combination of the ITG-GRACE03S gravitational model and its associated error covariance matrix, with the gravitational information obtained from a global set of area-mean free-air gravity anomalies defined on a 5 arc-minute equiangular grid. This grid was formed by merging terrestrial, altimetry-derived, and airborne gravity data. Over areas where only lower resolution gravity data were available, their spectral content was supplemented with gravitational information implied by the topography. EGM2008 is complete to degree and order 2159, and contains additional coefficients up to degree 2190 and order 2159. Over areas covered with high quality gravity data, the discrepancies between EGM2008 geoid undulations and independent GPS/ Leveling values are on the order of 5 to 10 cm. EGM2008 vertical deflections over USA and Australia are within 1.1 to 1.3 arc-seconds of independent astrogeodetic values. These results indicate that EGM2008 performs comparably with contemporary detailed regional geoid models. EGM2008 performs equally well with other GRACE-based gravitational models in orbit computations. Over EGM96, EGM2008 represents improvement by a factor of six in resolution, and by factors of three to six in accuracy, depending on gravitational quantity and geographic area. EGM2008 represents a milestone and a new paradigm in global gravity field modeling, by demonstrating for the first time ever, that given accurate and detailed gravimetric data, a single global model may satisfy the requirements of a very wide range of applications.
WP 013 eGaN ® FETs for Envelope Tracking eGaN ® FETs for Envelope Tracking EFFICIENT POWER CONVERSION

INTroducTIoN The concept of envelope tracking (ET) for radio frequency (RF) amplifiers is not new. But with the ever increasing need for improved cell phone battery life, better base station energy efficiency, and more output power from very costly RF transmitters, the need for improving the RF Power Amplifier (PA) system efficiency through ET has become an intense topic of research and development. There are many papers on the basics and advantages of envelope tracking [1-6]. The key to their ability to improve efficiency lies in the PA’s peak to average power (PAPR) requirements [3]. As shown in Figure 1 it is possible to achieve peak PA efficiencies as high as 65% with a fixed supply, but given PAPRs as high as 10, the average efficiency is likely to be lower than 25%. Through modulation of the PA supply voltage, this can be improved to over 50% essentially doubling the efficiency and reducing PA losses by two thirds! This will not only reduce power consumption, but also lower the cost of operation, cooling requirements, size etc. [7]. But how to generate the required fast moving supply voltage, the bandwidth of which can be in the tens of megahertz range [3]? A variety of different approaches have been investigated to achieve this. One such method would be implemented through the use of a hybrid linear-amplifier and multi-phase buck converter as shown in Figure 2 [8], where the buck converter supplies only the high-power, but lower-frequency transient components. Alternative methods employing boost converters [9] or Class-S amplifiers have also been discussed. Regardless of the implementation, Gallium nitride is being seen an as enabling technology for both ET converters and wide bandwidth RFPA designs. Implementing a multi-phase buck converter would traditionally require switching frequencies 5-10 times higher than the required ET bandwidth, but research into raising the converter’s effective bandwidth through hybrid solutions [8] and/or non-linear control [10] allows the required buck converter switching frequency to be greatly reduced. Even so, a large number of interleaved phases may still be required to achieve acceptable efficiency and bandwidth. The aim of this paper is to show what power and efficiency levels are readily realizable using current eGaN FETs and the LM5113 eGaN FET half-bridge driver [11]. Johan Strydom, Ph.D., V.P., Applications, Efficient Power Conversion Corporation (www.epc-co.com)
Diet of the Kotschy ’ s Gecko Mediodactylus kotschyi rumelicus ( Müller , 1940 ) ( Reptilia : Gekkonidae ) from the City of Plovdiv ( Bulgaria )

The seasonal and habitat variation of the trophic spectrum of Kotschy’s gecko (Mediodactylus kotschyi rumelicus), as well as the species’ trophic niche breadth was studied, based on feces analysis. The material was collected in spring and autumn of 2007 and 2008. The diet of M. kotschyi consists mainly of insects (59.51%), and from the non-insect food we registered Aranea (3.46%) and Acari (4.50%). From the insects, largest share have the ants Hymenoptera, Formicidae (41.18%), followed by Coleoptera (11.77%), represented mainly by the Curculionidae family and Heteroptera (3.46%). In most of the samples (93.41%) were identified a significant amount of plant residues (32.52% of the total food). The taxonomic contents of the gecko’s diet remains almost unchanged in the spring and in the autumn. The index of dominance of Berger-Parker (d) showed a moderate value of 0.41 and the trophic niche breadth, calculated with Simpson’s diversity index (1/ Simpson) was 3.53, which is relatively low value.
ff ect and economic growth : Do national increases in intelligence lead to increases in GDP ?

According to the cognitive human capital theory, cognitive ability furthers at the individual, institutional and societal level productivity, production, income and wealth. Cross-sectional and longitudinal studies using various indicators (psychometric IQs, student assessment tests, education vs. GDP per capita, growth), different methods (correlations, regressions, path models) and different controls have supported this theory in two research paradigms (psychology, economics). An especially revealing test is, whether historical increases in IQ within countries would lead to later economic growth, i.e. about 10 to 20 years later. This design can exclude national differences being associated with human capital and growth (e.g., in culture, economic freedom and politics) which may bias the results. We used a data set of national IQ changes (“FLynn effect”) from Pietschnig and Voracek (2015). For a maximum of 28 nations and 262 periods between 1909 and 2013 IQ development was related to concurrent or lagged GDP per capita development (growth; 5, 10, 15, 20 years). In a second analysis with at least three IQ-GDP periods per country the single within-country correlations for concurrent and later intervals were estimated (13 nations). Finally, we controlled for previous wealth (advantages of backwardness). All analyses show substantial relationships between increases in IQ and GDP, the highest were found for the 5 to 15 years lagged economic growth (r= .25 to .44 resp. .46 to .77). The results back the theory that cognitive ability contributes to wealth.
Polymorphisms in the IL 17 A gene are not involved in the development of preeclampsia in the Brazilian population Polimorfismos no gene IL 17 A não estão envolvidos no desenvolvimento de pré-eclâmpsia na população brasileira

First submission on 10/11/18; last submission on 12/05/18; accepted for publication on 10/11/18; published on 04/20/19 aBStraCt Introduction: Preeclampsia is defined by the development of hypertension associated with proteinuria after the 20 week of gestation in previously normotensive women. IL17A is a potent inducer of tissue inflammation and polymorphisms in the IL17A gene can modulate gene expression and affect the functioning of Th17 cells, strengthening susceptibility to preeclampsia. Objective: To investigate the polymorphisms rs4711998 A> G, rs8193036 C> T and rs2275913 A> G in the IL17A gene in women with preeclampsia. Methods: This is a control case study, composed of 263 women, 89 with preeclampsia and 174 of the control group. The polymorphisms investigated by real time polymerase chain reaction (PCR) allele discrimination technique. The risk of IL17A polymorphisms contributing to preeclampsia was assessed by the inheritance model through logistic regression. Statistical power presented 99.5% for association detection. Statistical significance was defined as p < 0.05. Results: Genotype frequencies as well as multiple logistic regression analysis were not statistically significant for the rs4711998 A>G, rs8193036 C>T and rs2275913 A>G polymorphisms of the IL17A gene. No association was found between any haplotypes of the polymorphisms investigated and the risk of developing PE. Conclusion: There is no association between the allele frequencies, genotype, inheritance models and haplotypes of the rs4711998 A>G, rs8193036 C>T and rs2275913 A>G polymorphisms of the IL17A gene and PE.
Biological notes on Parahypopta caestrum and first microbiological control assays

We provide notes about the biology and the ethology of Parahypopta caestrum (Hubner) (Lepidoptera Cossidae), based on field observations conducted in asparagus plantations in Apulia region, Italy. Furthermore, the effect of 6 entomopathogenic nematode (EPN) strains (Steinernematidae and Heterorhabditidae) and 3 entomopathogenic fungal (EPF) isolates (Beauveria bassiana) was evaluated in laboratory assays against III instar larvae of the asparagus moth. The results showed that all the nematodes and fungal strains affected the asparagus moth survival, except the Steinernema affine and Heterorhabditis bacteriophora strains. Steinernema feltiae and B. bassiana showed the best performances, killing on average 90% of the P. caestrum larvae. Considering the lack of effective chemical control means, the microbiological control of the asparagus moth by EPNs and EPFs reveals promising perspectives and needs further investigations.
Integrated Navigation using GIS-based Information

This paper describes the usefulness of a GIS for integrated navigation of intelligent vehicles. In many applications, the use of GPS alone is not sufficient and needs the help of dead-reckoned sensors, map data and additional sensors like cameras or ladars (laser scanners). Geographical information can be used in two different ways. First, pre-existing features of the environment like roads can be used as constraints of localisation space. Second, the geographical information can include the landmark locations. The GIS can be used to manage this information. These two characteristics are described through the case study of a localisation system for urban areas.