Miracle-dz/UniFAR-FTUs huggingface dataset:
Comprehensive competitive endogenous RNA network analysis reveals EZH2-related axes and prognostic biomarkers in hepatocellular carcinoma

Objective(s): Hepatocellular carcinoma (HCC) is a common and lethal type of cancer worldwide. The importance of non-coding RNAs such as long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and microRNAs (miRNAs) have been recognized in the development of HCC. In this study, we constructed a four-component competing endogenous RNA (ceRNA) network in HCC and evaluated prognostic values of the ceRNAs. Materials and Methods: The expression profiles of lncRNAs, miRNAs, and mRNAs were retrieved from The Cancer Genome Atlas database. GSE94508 and GSE97332 studies from the Gene Expression Omnibus database were used to identify circRNAs expression profiles. A four-component ceRNA network was constructed based on differentially-expressed RNAs. Survival R package was utilized to identify potential prognostic biomarkers. Results: A four-component ceRNA network including 295 edges and 239 nodes was constructed and enrichment analysis revealed important Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathways. A Protein-Protein Interaction network with 118 nodes and 301 edges was also established. The enhancer of zeste homolog 2 (EZH2) was the highest degree hub gene in the PPI network. Because of the significance of EZH2 in HCC, we presented its axes in the ceRNA network, which play important roles in HCC progression. Furthermore, ceRNAs were identified as potential prognostic biomarkers utilizing survival analysis. Conclusion: Our study elucidates the role of ceRNAs and their regulatory interactions in the pathogenesis of HCC and identifies EZH2-related RNAs which may be utilized as novel therapeutic targets and prognostic biomarkers in the future.
Identification of molecular pathways and protein-protein interactions in adipose tissue-derived mesenchymal stromal cells (ASCs) under physiological oxygen concentration in a diabetic rat model

Objective(s): Adipose tissue-derived mesenchymal stromal cells (ASCs) are useful in cell-based therapy. However, it is well known that diabetes mellitus (DM) alters ASCs’ functionality. The majority of in vitro studies related to ASCs are developed under non-physiological oxygen conditions. Therefore, they may not reflect the full effects of DM on ASCs, in vivo. The main aim of the current study is to identify molecular pathways and underlying biological mechanisms affected by diabetes on ASCs in physiological oxygen conditions. Materials and Methods: ASCs derived from healthy (ASCs-C) and diabetic (ASCs-D) rats were expanded under standard culture conditions (21% O2) or cultured in physiological oxygen conditions (3% O2) and characterized. Differential gene expressions (DEGs) of ASCs-D with respect to ASCs-C were identified and analyzed with bioinformatic tools. Protein-protein interaction (PPI) networks, from up- and down-regulated DEGs, were also constructed. Results: The bioinformatic analysis revealed 1354 up-regulated and 859 down-regulated DEGs in ASCs-D, with 21 and 78 terms over and under-represented, respectively. Terms linked with glycosylation and ribosomes were over-represented and terms related to the activity of RNA-polymerase II and transcription regulation were under-represented. PPI network disclosed RPL11-RPS5 and KDR-VEGFA as the main interactions from up- and down-regulated DEGs, respectively. Conclusion: These results provide valuable information about gene pathways and underlying molecular mechanisms by which diabetes disturbs ASCs biology in physiological oxygen conditions. Furthermore, they reveal, molecular targets to improve the use of ASCs in autologous transplantation.
Aerodynamic design of a small centrifugal compressor

An aerodynamic design of a small centrifugal compressor for some pilotless aircraft was presented in this paper.One-dimensional thermal calculation was conducted to configure the flow path.And based on two-dimensional through flow design,the required aerodynamic performance was obtained by adjusting the distribution of velocity circulation of the blade rows.Then three-dimensional blade airfoils can be got by arbitrary camber lines blading.At last,three-dimensional CFD(computational fluid dynamics) calculation was used to analyze the result of the aerodynamic design.All performance parameters of the centrifugal compressor meet the design requirement at design point.And the performance curves at all speeds are really flat.Therefor the work stability of the compressor have a fairly broad scope.
-THEIR RELATION WITH WAVE FRONT SETS AND BESOV, TRIEBEL-LIZORKIN SPACES-

Introduction. We define a class of wavelet transforms as a continuous and micro-local version of the Littlewood-Paley decompositions. Hormander's wave front sets as well as the Besov and Triebel-Lizorkin spaces may be characterized in terms of our wavelet transforms. We remark that the components of our decompositions are not linearly independent but can be treated as if they were. This paper consists of two parts. The first part treats the comparison between the wave front sets defined by our wavelet transforms and Hormander's wave front sets. The second part gives the characterization of the Besov and Triebel-Lizorkin spaces by using our wavelet transforms First, we define our wavelet transforms as follows:
Package ‘intRvals’

May 3, 2022 Type Package Title Analysis of Time-Ordered Event Data with Missed Observations Version 1.0. 1 Date 2022-05-02 Author Adriaan M. Dokter Maintainer Adriaan M. Dokter <amd427@cornell.edu> Description Calculates event rates and compares means and variances of groups of interval data corrected for missed arrival observations. License GNU General Public License Imports plyr,lme4 LazyData TRUE Encoding UTF-8 RoxygenNote 7.1. 2 NeedsCompilation no Repository CRAN Date/Publication 2022-05-02 22:52:12 UTC
Running Head: CHILD ATTRIBUTIONS FOR PARENTS’ BEHAVIOR Attributions for Parents’ Behavior by Boys with and without Attention-Deficit/Hyperactivity Disorder

Attributions for parents’ behavior were examined in a sample of boys with and without Attention-Deficit/Hyperactivity Disorder (ADHD). Sixty-six boys (mean age = 9.75 years) rated attributions for their mothers’ and their fathers’ behavior, across positive and negative scenarios, and along four attribution dimensions (parent ability, parent effort, task difficulty, and child responsibility). Three-way interactions emerged among child ADHD status, parent gender, and attribution type, and among scenario valence, parent gender, and attribution type. All children rated attributions higher in the positive scenarios, and attributions of child responsibility higher for fathers than mothers. Children rated task-related attributions higher for mothers in negative scenarios, but higher for fathers in positive scenarios. Boys with ADHD rated child responsibility attributions higher than controls, across all scenarios. Results highlight important differences in children’s perceptions of their parents’ behavior that may have implications for understanding parent-child relationships in families of children with and without ADHD.
Iheringia, Série Botânica

This study was designed to develop an efficient protocol for Lallementia royleana in vitro culturing and to analyze the effect of various hormones on its culturing ability. The indirect organogenesis and its callogenetic ability were evaluated; with the best (100%) results with 1 mg L-1 of benzyl aminopurine (BAP) and 2 mg L-1 of indole acetic acid (IAA) combination. In direct regeneration, leave petioles, nodes and internodes explants were cultured for shooting on various concentrations of BAP and kinetin (KIN). Maximum shooting (80%) was obtained from nodal parts with 1.0 mg L-1 of BAP and 0.5 mg L-1 of KIN. Similarly, the best in vitro rooting (24 roots) was achieved with 1 mg L-1 naphthalene acetic acid (NAA). Lallementia royleana showed higher regeneration through direct regeneration than callogenesis. Significant variability (p = 0.002625) among callus induction, plant parts and hormonal combinations were observed. The node and internode explants showed observable callus responses in combinations of 2, 4-Dichlorophenoxyacetic acid (2,4-D) with NAA, and BAP with IAA.
Cancer Immunity, Vol. 5, p. 2 (1 February 2005)

Cancer-testis or germ cell antigens (GCAs) are a category of tumor antigens expressed by male germ cells and by cancers of diverse histological origin, but not usually by normal adult somatic tissue. These antigens include products encoded by the MAGE, BAGE, GAGE, SSX, and LAGE/NY-ESO-1 families that encode antigenic peptides recognized by T lymphocytes. In this study, we exploit oligonucleotide technology to identify genes in melanoma and soft tissue sarcoma (STS) that display a cancer-testis/GCA expression profile. We identified 59 such genes, including GCAs we knew to be recognized by T lymphocytes. Among our findings are the expression of PRAME in monophasic synovial sarcoma, PRAME and NY-ESO-1 in myxoid/round cell liposarcoma, and SSX2 and members of the GAGE family in malignant fibrous histiocytoma. Furthermore, the proto-oncogene DBL/MCF2 was identified as encoding a novel candidate GCA expressed by clear cell sarcoma/melanoma of soft parts (MSP). DBL/MCF2 peptides that are bound to HLA-A*0201 were identified and recognized by T lymphocytes. These results show the utility of high-throughput expression analysis in the efficient screening and identification of GCA candidates in cancer, and its application to the discovery of candidate targets for T cell immunity against GCAs expressed by cancer.
Comparison of yield -vertex tangential loading and principal stress rotational loading

The yield-vertex tangential loading theory is a constit utive approach that accounts for the plastic straining induced by the part of a stress rate directed tangen tial to the yield surface. One of the important applications of this theory is in the study of ge otechnical problems involving significant rotation of principal stress directions. However, it is ina ccurate to simply regard the tangential loading as an equivalence to the principal stress rotation. For future reference, this paper presents an investigation into the difference between the tangential loading theory and a true purely principal stress rotational loading theory . Mathematical derivation shows that the tangential stres ate includes the rotational stress rate and an additional coaxial term that is ssociated with the variation of the Lode angle. Numerical applications of these two theories indi cate that in shear dominated problems, such as simple shear, the two theories are almost identical a nd interchangeable, but in non-shear dominated circumstances, such as footing, the tangential loading the ory produces considerably softer results than the rotational loading theory.
E Electricity Market Scheduling Applications in Russia

Reform of the power energy sector in Russia in the beginning of the 2000s led to development of a competitive electricity market and emergence of a number of independent generation and distribution companies. An overview of the market model and overall reform process is given in Davidson et al. (2004) and Letova, Yao, Davidson, and Afanasyeva (2018). Most part of the energy system of Russia is interconnected and operates at a single frequency. The system is highly constrained and is characteristic for significant power transfers over highvoltage backbone grid. Simplified linearized models widely used in many energy markets might lead to critical scheduling errors and nontransparent deviations. A new short-term scheduling market-based technology that uses explicitly nonlinear power flow equations in accordance with alternating current model (AC model) was developed. The AC model yields the required accuracy in modeling losses and power flows to correctly account for the constraints set up by the system operator. As a result market-based schedules and pricing signals stand closer to real dispatch, and their economic value for the market participants is greater. Since 2006–2007 the technology is exploited by the commercial market operator (Administrator of the Trading System – ATS) that runs the day-ahead market and the system operator (SO) that runs the balancing market. The aim of the latter is to reflect the most recent system conditions and to trade deviations from the day-ahead market. Balancing market schedule is computed every 1 h ahead of real time, and the resulting generation station schedules have a status of dispatch instructions.
Site-shifting as the source of ambidexterity: The strategy-as-practice perspective

Ambidexterity, defined as the capability to simultaneously explore knowledge to identify new market opportunities and exploit knowledge to capitalise on a firm’s existing niches, is considered to be crucial in todays competitive marketplace. However, there is relatively limited research on how such a capability can be developed, and even less on the role of IT-enabled practices in promoting this. Drawing on the strategy-as-practice perspective, we investigate how interrelationships amongst practitioners, IT-enabled practices and praxis create a particular site of practice. More importantly, we consider how a site gets shifted over time through the emergence of changes in the interrelationships between practices, practitioners and praxis in conjunction with exploiting affordances offered by the use of different types of IT. Building on the findings derived from a case study of DaM 1 , the leading ticketing company in China, we explain how the phenomenon of site-shifting can provide a useful conceptual lens for explaining ambidexterity. In doing this, we bring to the fore the importance of IT in achieving an ambidexterity capability.
HOW MUCH UNEMPLOYMENT IS STRUCTURAL IN TURKEY? AN UNOBSERVED COMPONENTS APPROACH

BARİ  ABSTRACT This study aims to determine the course of structural unemployment by decomposing trend and cyclical components of 1987-2019 actual unemployment in Turkey. This decomposition will be carried out in the context of time-varying NAIRU (Non-Accelerating Inflation Rate of Unemployment). It is accepted that structural unemployment is the unemployment that is consistent with the performance of the economy at the potential output level and, therefore, can be proxied by the time-varying NAIRU. The developments in Turkish labor markets during the investigation period emphasize that the importance of structural factors besides the cyclical ones. Therefore, it is crucial to examine how much of the increase in the unemployment rate is structural in the Turkish economy. Structural unemployment rate figures obtained through the state-space model estimated by using reduced form accelerationist Phillips curve indicate the presence of high and increasing structural unemployment problems in Turkey, specifically during the last years. Alternative models like Beveridge curve and Hodrick – Prescott filtering also produce results confirming this determination and reveal that the unemployment gap is almost closing in
NLRP12 is associated with both Depression and Artery disease in Vietnam veterans.

Inﬂammasome Several studies have established that Major depressive disorder is associated with excess inflammation with an elevation of both pro and anti-inflammatory cytokines in major depressive disorder. In addition, individuals with major depressive disorder are at higher risk of developing coronary artery disease. The role of innate immunity and NFκB-mediated inflammation in depression and its increased association with coronary artery disease is yet to be fully elucidated. Polymorphisms in the Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat and Pyrin Domain Containing 12 (NLRP12), are associated with depression and coronary artery disease in trauma exposed individuals.
Why Culture Influences Eye Movements? Understanding Cultural Effect on Visual Attention by Comparing Passive and Active Observation by

Previous works suggest that North Americans perceive visual information more analytically while East Asians perceive visual information more holistically. However, salient objects are also known to naturally attract human attention. Current studies examined to what extent culture influences visual attention. Study 1 demonstrated that highly salient objects attract passive viewers’ attention similarly across North American and East Asian cultures. In study 2, however, we revealed that such strong tendency for humans can be influenced by culture when people actively engaged in the observation. When participants were asked to report their observation, Canadian participants predominantly reported information regarding focal objects whereas Japanese participants also reported much information regarding contextual features. Consistently, culturally divergent patterns of eye movements were observed. The current study thus indicates that the active involvement in observation is especially important to understand the influence of culture on visual attention. Acknowledgement Foremost, I would like to express my sincere gratitude to my supervisor, Dr. Takahiko Masuda. I thank for his support and guidance, and mostly, for teaching me the way to approach science with diligence and commitment. I would like to extend my appreciation to my committee members, Dr. Kim Noels, Dr. Elena Nicoladis, and Dr. Kaori Kabata. I am very grateful for detailed comments and inspiring discussion about culture. I would also like to thank my lab members, Dr. Huaitang Wang, Dr. Jianhui Song, Kenichi Ito, and research assistants who have helped me at various stages of this project. I would like to make a special reference to Dr. Keiko Ishii, Dr. Yosuke Otsubo, and members of the Department of Psychology at the Kobe University. Without their corporation, I could not collect such valuable data. Finally, I sincerely thank my family, and especially my husband Casey, for giving me continuous support and encouragement. Table of
Synthesis, characterisation and potential biomedical applications of magnetic coreâ•fishell structures: carbonâ•’, dextranâ•’, SiO<sub>2</sub> â•’ and ZnOâ•’coated Fe<sub>3</sub> O<sub>4</sub> nanoparticles

Due to the strong effect of nanoparticles' size and surface properties on cellular uptake and bio-distribution, the selection of coating material for magnetic core–shell nanoparticles (CSNPs) is very important. In this study, the effects of four different biocompatible coating materials on the physical properties of Fe3O4 (magnetite) nanoparticles (NPs) for different biomedical applications are investigated and compared. In this regard, magnetite NPs are prepared by a simple co-precipitation method. Then, CSNPs including Fe3O4 as a core and carbon, dextran, ZnO (zincite) and SiO2 (silica) as different shells are synthesised using simple oneor two-step methods. A comprehensive study is carried out on the prepared samples using X-ray diffraction, vibrating sample magnetometry, transmission electron microscopy and Fourier transform infrared spectroscopy analyses. According to the authors' findings, it is suggested that carbonand dextran-coated magnetite NPs with high Ms have great potential in the application of magnetic resonance imaging contrast agents. Moreover, silica-coated magnetite NPs with high coercivity are potentially suitable candidates for hyperthermia and ZnO-coated Fe3O4 is potentially suitable for photothermal therapy.
Precise tests of low energy QCD from Ke4 decay properties

We report results from the analysis of the K± → π+π−e±ν (Ke4) decay by the NA48/2 collaboration at the CERN SPS, based on the total statistics of 1.13 million decays collected in 2003–2004. The hadronic form factors in the Sand P-wave and their variation with energy are obtained. The phase difference between the Sand P-wave states of the ππ system is accurately measured and allows a precise determination of a0 0 and a2 0, the I = 0 and I = 2 S-wave ππ scattering lengths: a0 0 = 0.2220 ± 0.0128stat ± 0.0050syst ± 0.0037th, a2 0 = −0.0432 ± 0.0086stat ± 0.0034syst ± 0.0028th. Combination of this result with the other NA48/2 measurement obtained in the study of K± → π0π0π± decays brings an improved determination of a0 0 and the first precise experimental measurement of a2 0, providing a stringent test of Chiral Perturbation Theory predictions and lattice QCD calculations. Using constraints based on analyticity and chiral symmetry, even more precise values are obtained: a0 0 = 0.2196 ± 0.0028stat ± 0.0020syst and a2 0 = −0.0444 ± 0.0007stat ± 0.0005syst ± 0.0008ChPT.
Exploring abandoned mines through a public lens

Research suggests that there are potentially millions of abandoned mines around the globe. As such, it is highly probable that these operations have the potential of resulting in a magnitude of social and environmental issues. However, there is limited literature on their social impacts specifically to a local community. To explore this issue, we investigated four case studies through a literature review using a wide range of white, grey and peer-reviewed literature. We examined case studies in Australia, China, Europe, and the USA. From this preliminary review, we determined that all have a significant number of abandoned mines. We examined these Case Studies as their respective economies rely heavily on the mining industry. The terminology ‘’abandoned mines’’ is often ambiguous and potentially not well understood. Our research shines the spotlight on the problem and examines novel solutions to manage issues associated with abandoned mines. We also examine the closure requirements for abandoned mines in a broad setting, and how these operations can be successfully monitored using Unmanned Aerial Vehicles (UAVs). Accordingly, our aim was to explore a wide range of jurisdictions and determine how local communities are affected by abandoned mine, and where UAVs technologies are commonly utilised
Pyraclostrobin reduces germ tube growth of QoI-resistant Mycosphaerella graminicola pycnidiospores and the severity of septoria tritici blotch on winter wheat

The effect of the quinone outside inhibitors (QoI) azoxystrobin and pyraclostrobin on yields of winter wheat where QoI resistant Mycosphaerella graminicola isolates were dominant was investigated in ﬁeld trials in 2006 and 2007. Pyraclostrobin signiﬁcantly increased yields by 1 Æ 57 t ha ) 1 in 2006 and 0 Æ 89 t ha ) 1 in 2007 when compared to the untreated controls, while azoxystrobin only provided a signiﬁcant increase of 1 Æ 28 t ha ) 1 in 2006. These yield increases were associated with reduction in septoria tritici blotch (STB) development as determined by weekly disease assessments over a 7 week interval. The effect of pyraclostrobin on STB was studied in controlled environment experiments using wheat seedlings inoculated with individual M. graminicola isolates. Pyraclostrobin signiﬁcantly reduced STB symptoms by up to 62%, whether applied 48 h pre- or post- inoculation with resistant M. graminicola isolates containing the cytochrome b mutation G143A. Extremely limited disease (<1%) was observed on similarly treated seedlings inoculated with an intermediately resistant isolate containing the cytochrome b mutation F129L, while no disease was observed on seedlings inoculated with a wild-type isolate. Germination studies of pycnidiospores of M. graminicola on water agar amended with azoxystrobin or pyraclostrobin showed that neither fungicide inhibited germination of spores of resistant isolates containing the mutation G143A. However, pyraclostrobin signiﬁcantly reduced germ tube length by up to 46% when compared with the untreated controls. Although the QoIs can no longer be relied upon to provide effective M. graminicola control, this study provides an insight into why QoIs still provide limited STB disease control and yield increases even in situations of high QoI resistance.