Miracle-dz/UniFAR-FTUs huggingface dataset:
Neutrophil Recruitment in the Reperfused-Injured Rat Liver was Effectively Attenuated by Repertaxin, a Novel Allosteric Noncompetitive Inhibitor of Cxcl8 Receptors: A Therapeutic Approach for the Treatment of Post-Ischemic Hepatic Syndromes

Hepatic reperfusion injury represents a crucial problem in several clinical situations including liver transplantation, extensive hepatectomy and hypovolemic shock with resuscitation. Repertaxin is a new non-competive allosteric blocker of interleukin-8 (CXCL8) receptors, which by locking CXCR1/R2 in an inactive conformation, prevents receptor signaling and polymorphonuclear leukocyte (PMN) Chemotaxis. The present study shows that repertaxin dramatically prevents rat post-ischemic hepatocellular necrosis (80% of inhibition) and PMN infiltration (96% of inhibition) at a clinically-relevant time (24 h) of reperfusion. Treatment with repertaxin by continuous infusion is demonstrated to be the optimal route of administration of the compound especially in view of its clinical threrapeutic use. Because repertaxin has proven to be safe and well tolerated in different animal studies and in phase I studies in human volunteers, it is in fact a candidate novel therapeutic agent for the prevention and treatment of hepatic post-ischemic injury.
Improved light-microscopical detection of microsporidia spores in stool and duodenal aspirates. The Enteric Opportunistic Infections Working Group.

BACKGROUND The diagnosis of infection with Enterocytozoon bieneusi, a microsporidian organism that causes chronic diarrhea in patients infected with the human immunodeficiency virus (HIV), has depended on invasive procedures. We have developed a new method to detect microsporidia spores in feces and duodenal aspirates. METHODS Stool was obtained from four HIV-infected patients with biopsy-confirmed intestinal microsporidiosis. Slides prepared from unconcentrated, formalin-fixed stool specimens were stained with a new chromotrope-based technique and examined by light microscopy. Methods of stool concentration were also compared. The technique was then evaluated by examining 215 specimens from 134 HIV-infected persons with or without diarrhea. In addition, duodenal aspirates from 10 patients with unexplained chronic diarrhea were examined by light microscopy after staining according to the new and the traditional techniques. RESULTS E. bieneusi spores were found in all unconcentrated stool specimens from the four patients with microsporidiosis. The use of various methods of stool concentration did not improve the detection of microsporidia spores. In the prospective study, microsporidiosis was detected in samples from 6 of 27 patients with chronic diarrhea, but in none of those from 42 patients with acute diarrhea or 65 patients without diarrhea. The presence of microsporidia spores in stool specimens and duodenal aspirates allowed the successful prediction of the presence of microsporidia in small-bowel biopsy specimens from all four patients who subsequently underwent endoscopy. CONCLUSIONS E. bieneusi is an important cause of chronic diarrhea in HIV-infected persons. This new diagnostic technique serves as a practical, noninvasive means to detect microsporidia spores in stool specimens and is also applicable to the examination of duodenal aspirates.
LIPID PHASES IN RENAL BRUSH BORDER MEMBRANES REVEALED BY LAURDAN FLUORESCENCE *

Steady‐state fluorescence properties of 6‐dodecanoyl‐2‐dimethylaminonapththalene (Laurdan) have been used to determine the coexistence of separate lipid‐phase domains in apical brush border membrane vesicles isolated from the rat renal cortex. The temperature dependence of generated polarization has been utilized to quantitate the lipid phases. Finally, the effect of cholesterol enrichment on these parameters has been studied. The results indicate the coexistence of lipid‐phase domains in brush border membranes based on the values of the generalized polarization and assuming that the membrane state can be described by coexistence of gel and liquid crystalline state. At 37°C, approximately19–32% of the brush border membrane lipids are in the gel phase, and cholesterol enrichment causes a further concentration‐dependent increase in the gel phase of brush border membrane lipids.
Phage Display Technology in Antibody Engineering: Design of Phagemid Vectors and in vitro Maturation Systems

The utilization of specific, high-affinity hutnan monoclonal antibodies in therapy of neoplasms, viral and bacterial infections and autoimmune disease has been a desire of clinicians since the introduction of monoclonal antibodies. The human hybridoma technology has, however, always been hampered by the fact that immunological specificity could in most cases, due to ethical reasons, not be generated by immunizing human individuals. Several in vitro immunization approaches have been developed that circumvent the ethical problems (Borrebaeck 1988, Ohlin & Borrebaeck 1992), although immunization of naive human B cells in vitro has only generated primary immune responses. Thus, human monoclonal antibodies generated by this approach are nonnally low-intermediate affmity IgM antibodies (Ohlin et al. 1989) and not directly applicable in a clinical situation. Recently, the advent of cloning antibody genes and displaying the antibody fragments on the surface ofa bacteriophage (McCafferty et al. 1990, Kang et al. 1991) has given us a unique tool to screen for immunological specificities. However, we still need to generate specific human B cells from which we can isolate the genes coding for the antibody variable domains, since the phage display technology does not per se generate any immunological specificities. The future will reveal if a combination of phage display technology with, e.g., in vitro immunization or primary/secondary immunization of Scid mice, transplanted with a human immune system (Carlsson et al. 1992), will provide the desired antibody specificities, or if so-called "naive libraries" in combination with in vitro afiinity maturation (see below) will offer the possibility to generate therapeutically useful human antibodies.
IDEC-C2B8: results of a phase I multiple-dose trial in patients with relapsed non-Hodgkin's lymphoma.

PURPOSE To evaluate the safety, pharmacokinetics, and biologic effect of multiple doses of the chimeric anti-CD20 monoclonal antibody (mAb) IDEC-C2B8 in patients with relapsed B-cell lymphoma. PATIENTS AND METHODS Twenty patients with relapsed low-grade (n = 15) or intermediate-/high-grade (n = 5) lymphoma received weekly infusions times four of 125 mg/m2 (n = 3), 250 mg/m2 (n = 7), or 375 mg/m2 (n = 10) of IDEC-C2B8. RESULTS Infusional side effects during the initial infusion were mainly grade I/II fever, asthenia, chills, nausea, rash, and urticaria. More serious events were rare. Peripheral-blood B cells were rapidly depleted and slowly recovered over 3 to 6 months. There was no change in mean immunoglobulin (Ig) levels. Antibody serum half-life (and maximum concentration [Cmax]) generally increased between the first and fourth infusions (33.2 hours v 76.6 hours, respectively) following the 375-mg/m2 doses. Six of 18 assessable patients had a partial remission (PR), with a median time to disease progression of 6.4 months (range, 3 to 21.7). Minor responses (MRs) were observed in five patients and progressive disease (PD) in seven. Tumor responses occurred in peripheral blood, bone marrow (BM), spleen, bulky lymph nodes, and extranodal sites, and in patients who had relapsed following high-dose myeloablative chemotherapy. Six of 14 patients (40%) with a low-grade histology responded. Four of six with bulky disease had a PR. CONCLUSION IDEC-C2B8 chimeric anti-CD20 mAb therapy is well tolerated and has clinical activity in patients with relapsed B-cell lymphoma. The 375-mg/m2 dose has been selected for a phase II trial in patients with relapsed low-grade or follicular B-cell lymphoma.
Dead code elimination technique in eclipse compiler for Java

Eclipse compiler for Java (ECJ) is open source incremented compiler. We reform features of ECJ, related to optimization technique called as dead code detection and elimination. ECJ identifies the dead code. We are extending this compiler to eliminate the dead code. In this paper we are describing the structure of ECJ. For dead code elimination approach we have used Single Static Assignment (SSA) strategy. After applying definition- use (DU) chain on SSA, we detect dead code and eliminate it. In this paper we are describing two algorithms: 1) To convert Java source code into SSA. 2) To eliminate dead code. Hence by implementing dead code elimination in ECJ, we are utilizing space and execution time of program which leads to improve efficiency of compiler.
Time-Work Tradeoffs of the Single-Source Shortest Paths Problem

We give parallel algorithms that solve the single-source shortest paths problem on a weighted, undirected graph withnvertices andmedges inO(tlgn) time andO((n3/t2)lgnlg(n/t)+mlgn) work, or inO(tlgn) time andO((n3/t3+mn/t)lgn) work for anytin the range lgn? t? n. These algorithms run on the EREW PRAM model. They are the first strongly polynomial exact algorithms that run ino(n) time while doingo(n3) work.
Elit Bayan Basketbolcularda Antropometrik Özellikler, Dikey Sıçrama ve Omurga Esnekliğinin Mevkilere Göre İncelenmesi

Bu calismanin amaci; elit bayan basketbolcularda antropometrik ozellikler, dikey sicrama ve omurga esnekliginin mevkilere gore degiskenligini incelemektir. Calismaya, Turkiye Basketbol Liglerinden 4 farkli takimda oynayan 41 elit bayan basketbolcu alindi. Oyuncular, oynadiklari mevkilere gore; oyun kurucu (n=13), forvet (n=14) ve pivot (n=14) olarak uc gruba ayrildi. Arastirmaya katilan sporcularin antropometrik ozellikleri, dikey sicrama yukseklikleri, omurga esneklikleri, vucut yag degerleri belirlendi ve sporcularin mevkileri ile karsilastirildi. Pivotlarin boylari ve vucut agirliklari forvet ve oyun kuruculardan yuksek bulundu. Sporcularin; vucut yag yuzdesi, yagsiz vucut kitlesi, deri kivrim kalinliklari, ust ve alt ekstremite uzunluklari, cap ve cevre olcumleri oynadiklari mevkilere gore karsilastirildiginda mevkiler arasinda istatistiksel olarak anlamli farklar tespit edildi (p 0.05). Pivotlarin somatotiplerinin mezomorfi, oyun kurucularin ve forvetlerin ektomorfi oldugu tespit edildi. Sonuc olarak; elit bayan basketbol takimlarinin yetenek secimlerinde, mevkilere gore motorik ve morfolojik ozelliklerin dikkate alinmasinin performansi olumlu yonde etkileyecegi dusunulmektedir
Visual Detection of Transposition of the Maize Element Activator (Ac) in Tobacco Seedlings

A bacterial streptomycin resistance gene (SPT) was engineered to make it possible to detect visually the transposition of the maize transposon Activator (Ac) in tobacco. In the presence of streptomycin, transgenic seedlings carrying the SPT gene appear green, whereas those carrying an SPT:: Ac construct display clones of green cells on a white background. Fully green seedlings arise in the progeny of SPT:: Ac transformants as a result of excision of Ac before fertilization. About half of these germinal revertants carry a transposed Ac element. Therefore, SPT:: Ac constitutes an efficient marker for selecting plants that have undergone transposition. In maize, there is a negative effect of increasing Ac dosage on the frequency and timing of Ac transposition. This negative effect is not observed in tobacco with the streptomycin variegation assay.
Evaluation of occurrence of NO3-, coliform and atrazine in a karst aquifer, Colombo, PR.

A vulnerabilidade de aquiferos do tipo carsticos a contaminacao por atividades agropecuarias ocorre em funcao de sua estrutura geomorfologica. No entanto, existem poucos estudos desta natureza no Brasil. O objetivo deste estudo foi avaliar a ocorrencia de nitrato, bacterias coliformes e atrazina em pocos rasos e profundos no aquifero carstico paranaense sob influencia de atividades agricolas. O estudo foi realizado em uma area de agricultura intensiva sobre aquifero carstico da bacia hidrografica do Alto Iguacu/Ribeira no municipio de Colombo-PR. As campanhas amostrais foram realizadas no periodo entre 2014 e 2015 em 15 pocos rasos e 7 pocos profundos, para analise bacteriologica, de NO3- e de atrazina na agua. A concentracao de NO3- nos pocos rasos variou entre 0,14 mg L-1 e 40,22 mg L-1. Nos pocos profundos, as concentracoes foram menores, entre 1,24 mg L-1 e 17,86 mg L-1. A analise de coliformes totais e fecais apresentou a mesma tendencia da presenca deNO3-. A atrazina foi detectada em 5 pocos rasos e 4 profundos. Propriedades fisico-quimicas da atrazina, assim como, as fraturas do aquifero carstico e alta condutividade hidraulica podem ser consideradas como fatores determinantes no destino deste pesticida.
Optimisation of network structure using genetic techniques

Arguments contending that it is necessary to use structured neural networks for the solution of certain problem types are presented. Structure is imposed on connectivity, activation functions, and other parameters of the network to simultaneously optimize generalization ability and compactness of the network. An analogy is made between the development of biological nervous systems from their genetic coding and the generation of artificial neural networks from a parametric description. Experiments which use genetic techniques to optimize network structure for a specific class of problem are described. Results which demonstrate the effectiveness of genetic optimization of network specifications in comparison with other optimization techniques are given. The parallel asynchronous implementation of genetic algorithms on a Sun-3 network is briefly described
Variation in emergency department wait times for children by race/ethnicity and payment source.

OBJECTIVE To quantify the variation in emergency department (ED) wait times by patient race/ethnicity and payment source, and to divide the overall association into between- and within-hospital components. DATA SOURCE 2005 and 2006 National Hospital Ambulatory Medical Care Surveys. STUDY DESIGN Linear regression was used to analyze the independent associations between race/ethnicity, payment source, and ED wait times in a pooled cross-sectional design. A hybrid fixed effects specification was used to measure the between- and within-hospital components. DATA EXTRACTION METHODS Data were limited to children under 16 years presenting at EDs. PRINCIPAL RESULTS Unadjusted and adjusted ED wait times were significantly longer for non-Hispanic black and Hispanic children than for non-Hispanic white children. Children in EDs with higher shares of non-Hispanic black and Hispanic children waited longer. Moreover, Hispanic children waited 10.4 percent longer than non-Hispanic white children when treated at the same hospital. ED wait times for children did not vary significantly by payment source. CONCLUSIONS There are sizable racial/ethnic differences in children's ED wait times that can be attributed to both the racial/ethnic mix of children in EDs and to differential treatment by race/ethnicity inside the ED.
Optical Properties of Stranski-Krastanow and Strain-Free GaSb Quantum Dots on GaAs Substrates - Towards Sb-based Type-II Quantum Dot Emitters -

We report the optical characteristics of type II GaSb quantum dot (QD) formation on GaAs by either Stranski-Krastanow (SK) or interfacial misfit (IMF) growth mode. The growth mode selection can be controlled by the gallium to antimony (III/V) ratio where a high III/V ratio produces IMF and a low III/V ratio establishes the SK growth mode. The IMF growth mode produces strain-free QDs emitting at 1.35 μm at room-temperature (RT), while the SK growth mode produces highly-strained QDs emitting at 1.18 μm at RT. We also demonstrate the fabrication of light-emitting diode (LED) structures containing five layers of GaSb/GaAs QDs using the IMF growth mode. Electroluminescence (EL) peak at 1.3 μm from the stacked QDs is observed at RT, which would be applicable to GaAs-based photonic devices for fiber-optic communication systems.
Synthesis of application-specific on-chip networks

Author(s): Yan, Shan | Abstract: Networks-on-Chip (NoC) has been proposed as a scalable solution to the global communication challenges in nanoscale System-on-Chip designs. The use of NoCs with standardized interfaces facilitates the reuse of previously-designed and third-party-provided modules in new designs. Besides design and verification benefits, NoCs have also been advocated to address increasingly daunting clocking, signal integrity, and wire delay challenges. In this thesis, we present design methods for synthesizing NoC architectures that are optimized for specific applications. We first present a novel design flow that integrates floorplanning, NoC architecture synthesis, RTL generation, and detailed RTL design. The proposed design flow is very flexible in that it allows for different user-defined objectives and constraints. The proposed design flow also supports both unicast and multicast traffic. We then present two approaches to the NoC synthesis problem. The first approach is based on flow -set partitioning and Steiner-tree construction. In this approach, the problem is decomposed into the inter-related steps of finding a good flow-set partition, deriving a good physical network topology for each group using Steiner-tree-based algorithms, and providing an optimized implementation for the derived topologies. The second approach is based on a rip-up and re-route formulation that successively improves upon an intermediate solution by "ripping'' out a flow and freeing up any network resources occupied by it, then "re-routing'' the ripped-up flow over the remaining network. To consider multicast flows, the re-routing step is formulated as a minimum directed spanning tree problem. While both approaches are effective, we found that the rip-up and re-route approach is generally better. Therefore, we chose to extend this approach to consider two additional design dimensions. First, we describe extensions to consider 3D-NoC synthesis. This is motivated by the increasing viability of 3D integration that has opened new opportunities for chip design innovations. To support 3D-NoC synthesis, we propose accurate power and delay models for 3D-wires with through-silicon-vias. Second, we describe extensions to support multiple traffic profiles, which are useful for design applications that support multiple usage scenarios, each with its own traffic profile. Finally, all proposed algorithms have been integrated into a software package called ARIES.
Genotype-Phenotype Association Study Reveals CFI-Rs13104777 to be a Protective Genetic Marker Against Acute Anterior Uveitis

ABSTRACT Purpose: To investigate the roles of CFI, genotype-phenotype associations were identified in AAU. Methods: A case–control study was conducted in a total of 575 subjects consisting of 279 AAU patients and 296 healthy controls. Genotypic analyses were performed using Sequenom MassARRAY technology. Analyses were stratified to a series of clinical ophthalmic confounding factors. Results: A lower frequency of the CFI-rs13104777 C allele was found in the AAU cohort compared with the controls, and, thus, was significantly associated with AAU pathogenesis (p = 0.041, OR = 0.712, 95% CI: 0.513–0.987). Stratified analysis also demonstrated the associations may differ depending on the HLA-B27 status and laterality status. Conclusions: This study has revealed a significant genetic role for CFI-rs13104777 in AAU. This influence may be dependent on human leukocyte antigen (HLA)-B27 and disease laterality. Overall, the results provide evidence for a pathogenic role for CFI in AAU and expand our knowledge on the genetic basis of AAU.
Effect of conventional dental restorative treatment on bacteria in saliva.

Dental caries results from the dissolution of mineralized dental tissues by the metabolic by-products of oral bacteria colonizing the surface of teeth. The principal modality for dealing with this infectious process is through restorative treatment which removes the pathologic tissue and replaces it with a variety of inert materials. The purpose of this study was to evaluate the effect of traditional restorative treatment on select oral bacterial populations. Fifty-two females demonstrating high levels of mutans streptococci (greater than or equal to 2.5 x 10(4) colony forming units (cfu) per ml saliva) with no more than four missing posterior teeth were recruited for this study. Salivary levels of mutans streptococci, lactobacilli, total streptococci, and total cultivable bacteria were evaluated before, during, and after restorative treatment. Initial DMFS scores were established by two standardized examiners using bitewing radiographs and clinical examination, which was conducted under optimal conditions. All restorative treatment was completed by faculty members of the University of Alabama School of Dentistry using treatment plans developed by the DMFS examiners. The participants received a mean of 16.4 restored surfaces, which resulted in significant reductions of all the bacterial populations tested. All microbial populations monitored were predicted to return to their baseline levels within 151 days after restorative treatment in 50% of the participants. This study shows that conventional restorative treatment results in a significant reduction of bacterial populations including those associated with the dental caries process, i.e., mutans streptococci and lactobacilli. (ABSTRACT TRUNCATED AT 250 WORDS)
Intelligent controller for electric vehicle

This paper presents a novel approach with a rule based acceleration control strategy for electric vehicles. This proposal has a straight forward goal for minimizing the complexities of the existing controllers used in the vehicles. The use of fuzzy logic enables the heuristic rule based technique to be used as an efficient solution. The fuzzy logic controller designed here is a combination of fuzzy decision maker and fuzzy speed controller for the separately excited DC motor. The fuzzy decision maker is designed in such a way that it takes into account the batterypsilas state of charge, speed of the vehicle, type of terrain, road load, brake, acceleration, ultra capacitor state of charge, and operational gear as input parameters which gives the reference speed to the fuzzy speed controller according to the scenarios in Indian road conditions. simulation results would specify the performance of the new proposed fuzzy controller. This controller has also been implemented in the embedded chip, field programmable gate Array (FPGA).