Miracle-dz/UniFAR-FTUs huggingface dataset:
Building Evidence-based Practice in AAC Display Design for Young Children: Current Practices and Future Directions

Abstract Each time a practitioner creates or modifies an augmentative and alternative communication (AAC) display for a client, that practitioner must make a series of decisions about which vocabulary concepts to include, as well as physical and organizational features of the display. Yet, little is known about what factors influence the actual decisions and their outcomes. This research examined the design factors identified as priorities by speech-language pathologists (SLPs) when creating AAC displays for young children (age 10 years and under), and their rationale for the selection of these priorities. An online survey gathered ratings and comments from 112 SLPs with experience in AAC concerning the importance of a variety of factors related to designing an aided AAC display. Results indicated that some decisions were supported by existing research evidence, such as choosing vocabulary, collaborating with key stakeholders, and supporting partner modeling. Other decisions highlight areas for future research, including use of visual scene display layouts, symbol background color, and supports for motor planning.
Association between positive and negative affect and musculoskeletal pain among US home health aides

ABSTRACT As the US population ages, there is an expected increase in demand for home health aides (HHAs); therefore, it is important to ensure their occupational well-being. Previous studies have demonstrated associations between negative emotions and musculoskeletal pain. Using survey data collected from 285 HHAs, we characterize the association between affect and musculoskeletal pain. Affect was measured using the Positive and Negative Affect Schedule, while musculoskeletal pain was measured using the Brief Pain Inventory. We found that as positive affect composite score increased, musculoskeletal pain decreased [β = –0.57, t(124) = –7.01, p < . 001]. There was no significant association between the negative affect composite score and musculoskeletal pain. However, several individual moods were associated with decreased or increased pain. These data suggest that some moods may buffer against musculoskeletal pain, while others may predispose HHAs to musculoskeletal pain.
Evaluation and Treatment of Premature Ejaculation: A Critical Review

Objective: Premature ejaculation is the most prevalent male sexual dysfunction. The present article is a comprehensive review of the literature on premature ejaculation. Method: This critical discussion of the literature evaluates the definitional issues, theoretical conceptualizations, assessment strategies, and treatment alternatives for premature ejaculation. Results: The review integrates the most recent findings on the diagnosis and treatment of premature ejaculation updating an earlier review with the addition of more than fifty recent articles and adding sections on treatment generalization and maintenance, medical evaluation, pharmacological intervention, and a discussion of methodological issues in the literature. Conclusions: The pause-squeeze technique remains the current treatment of choice for the disorder. However, this unitary treatment recommendation disguises a multidimensional disorder which has yet to evolve an operational definition, psychometrically sound assessment procedures, or clearly articulated etiology.
A microdeletion encompassing PHF21A in an individual with global developmental delay and craniofacial anomalies

In Potocki–Shaffer syndrome (PSS), the full phenotypic spectrum is manifested when deletions are at least 2.1 Mb in size at 11p11.2. The PSS‐associated genes EXT2 and ALX4, together with PHF21A, all map to this region flanked by markers D11S1393 and D11S1319. Being proximal to EXT2 and ALX4, a 1.1 Mb region containing 12 annotated genes had been identified by deletion mapping to explain PSS phenotypes except multiple exostoses and parietal foramina. Here, we report a male patient with partial PSS phenotypes including global developmental delay, craniofacial anomalies, minor limb anomalies, and micropenis. Using microarray, qPCR, RT‐qPCR, and Western blot analyses, we refined the candidate gene region, which harbors five genes, by excluding two genes, SLC35C1 and CRY2, which resulted in a corroborating role of PHF21A in developmental delay and craniofacial anomalies. This microdeletion contains the least number of genes at 11p11.2 reported to date. Additionally, we also discuss the phenotypes observed in our patient with respect to those of published cases of microdeletions across the Potocki–Shaffer interval. © 2015 Wiley Periodicals, Inc.
A Review of Forty-Five Years Study of Hiroshima and Nagasaki Atomic Bomb Survivors I. DOSIMETRY Allowing for Dose-Estimation Errors for the A-Bomb Survivor Data

Dose-errors/Cancer risk estimates/Errors-in-variables Unless allowances are made, random errors in radiation dose estimates cause underestimation of linear risk estimates and distort the shape of dose-response curves. These errors also result in spurious associations between radiogenic endpoints, exaggerating possible, variation in individual sensitivity to radiation. Statistical methods have been developed which reduce these biases, based on assumptions regarding the nature and magnitude of dose estimation errors. Some understanding of the underlying statistical basis for these methods is necessary to both those interested in interpreting radiogenic effects and those interested in the dosimetry system. This paper discusses the basic statistical issues and their implications, presents some statistical methods to deal with the problem, and indicates the sensitivity of certain results to assumptions about the magnitude of the dose-estimation errors.
A comparative study of monoaminergic involvement in the antinociceptive action of E-2078, morphine and U-50,488E.

E-2078 ([N-methyl-Tyr1, N-alpha-methyl-Arg7, D-Leu8]dynorphin A(1-8) ethylamide) is a systemically active dynorphin analog. We examined monoaminergic involvement in the antinociceptive action of E-2078 compared with morphine and U-50,488E (trans-3,4-dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)- benzene-acetamide monohydrochloride). The antinociceptive effect of these drugs was determined using the mouse tail-flick test after depletion of norepinephrine or 5-HT by pretreatment with various neurotoxins. Reserpine (i.p.) depleted both norepinephrine and 5-HT. Selective degeneration of noradrenergic nerves was induced by N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4, i.p.) or intrathecal (i.t.) 6-hydroxydopamine (6-OHDA), whereas 5-HT was depleted by p-chlorophenylalanine (PCPA, i.p.) or 5,7-dihydroxytryptamine (5,7-DHT, i.t.). The antinociceptive action of E-2078 administered s.c. was significantly attenuated in mice treated with reserpine, DSP-4, 6-OHDA, PCPA or 5,7-DHT compared with that in non-neurotoxin animals. Antinociception induced by intracerebroventricular (i.c.v.) and i.t. injection of E-2078 was reversed by reserpine, DSP-4 or PCPA. The antinociceptive action of morphine (s.c.) was attenuated by reserpine, DSP-4, 6-OHDA and PCPA, but not by 5,7-DHT. Antinociception produced by i.c. v. morphine was antagonized by reserpine, DSP-4 and PCPA. In contrast, morphine given i.t. was not affected by these neurotoxins. U-50,488E (s.c.)-induced antinociception was attenuated by reserpine, DSP-4, 6-OHDA, PCPA and 5,7-DHT. Intracerebroventricular U-50,488E was antagonized by reserpine, DSP-4 and PCPA, whereas i.t. U-50,488E was reversed only by reserpine and PCPA(ABSTRACT TRUNCATED AT 250 WORDS)
Clustering of Wind Farms and its Sizing Impact

The problem of establishing maximum size of a wind farm (WF) when it joins a WF cluster (WFC) is examined. It is shown that the clustering effect can be quantified by detailed simulation of system dynamics, using appropriate models for wind events, wind facilities, and power system equipment. The paper points out the inevitability of WFC formations and draws attention to their operational impacts. A case study is used to demonstrate how location and layout of a WF can influence system dynamics, and thus, restrict the WF size.
Folate, vitamin B12 and cognitive impairment in patients with Alzheimer's disease

This study examines the relationship between folate, vitamin B12 and severity of cognitive impairment in patients with Alzheimer's disease (AD) as compared with other disorders associated with cognitive impairment. The patients were 97 consecutive referrals to an AD clinic. Forty patients had either possible or probable AD. 31 had other dementias (OD) and 26 had mild cognitive impairment (cognitively impaired, not demented; CIND). Patients had blood drawn for serum, red cell folate and B12, as well as other biochemical indicators of nutrition, within 24 h of the Mini‐Mental State Examination (MMSE). In the AD group, only B12 was significantly correlated with MMSE. Using regression analysis, B12 contributed significantly to variance in MMSE. There was no correlation between MMSE and serum, red cell folate or B12 in the OD or CIND group and no significant correlation between MMSE and other nutritional indices in any group. These findings suggest the possibility of a specific relationship between B12 levels and severity of cognitive impairment in patients with AD.
Dynamic searchable encryption with privacy protection for cloud computing

The dynamic searchable encryption schemes generate search tokens for the encrypted data on a cloud server periodically or on a demand. With such search tokens, a user can query the encrypted data whiles preserving the data's privacy; ie, the cloud server can retrieve the query results to the user but do not know the content of the encrypted data. A framework DSSE with Forward Privacy (dynamic symmetric searchable encryption [DSSE] with forward privacy), which consists of Internet of Things and Cloud storage, with the attributes of the searchable encryption and the privacy preserving are proposed. Compared with the known DSSE schemes, our approach supports the multiusers query. Furthermore, our approach successfully patched most of the security flaws related to the sensitive information's leakage in the DSSE schemes. Both security analysis and simulations show that our approach outperforms other DSSE schemes with respect to both effectiveness and efficiency.
An Effective Approach to the Synthesis of Phase-Only Reconfigurable Linear Arrays

We present an effective approach to the optimal mask-constrained power pattern synthesis of uniformly spaced array antennas able to dynamically reconfigure their radiation pattern by modifying only the excitation phases. The proposed approach results in a design procedure having a very low computational burden and, by exploiting at best the knowledge available in the separate synthesis of each pattern, is able to solve the underlying combinatorial optimization problem and to achieve solutions close (or equivalent) to the global optimum. A set of representative examples are reported in order to validate the proposed approach. Some extensions of the developed theory to cases other than linear arrays are also outlined.
Dissociated Emergent-Response System and Fine-Processing System in Human Neural Network and a Heuristic Neural Architecture for Autonomous Humanoid Robots

The current study investigated the functional connectivity of the primary sensory system with resting state fMRI and applied such knowledge into the design of the neural architecture of autonomous humanoid robots. Correlation and Granger causality analyses were utilized to reveal the functional connectivity patterns. Dissociation was within the primary sensory system, in that the olfactory cortex and the somatosensory cortex were strongly connected to the amygdala whereas the visual cortex and the auditory cortex were strongly connected with the frontal cortex. The posterior cingulate cortex (PCC) and the anterior cingulate cortex (ACC) were found to maintain constant communication with the primary sensory system, the frontal cortex, and the amygdala. Such neural architecture inspired the design of dissociated emergent-response system and fine-processing system in autonomous humanoid robots, with separate processing units and another consolidation center to coordinate the two systems. Such design can help autonomous robots to detect and respond quickly to danger, so as to maintain their sustainability and independence.
Reluctance circuit analysis and structure optimization of contactless transformer

ConiaQi\ess transformer is the key component in inductive power transfer (IPT) system and its coupling coefficient (k) will directly affect the power transfer efficiency. In this paper, a contactless transformer applied in movable vehicle with the structure that primary and secondary sides are asymmetrical is studied. By analyzing the magnetic flux distributions of the transformer, magnetic reluctance circuit of this contactless transformer is built, and the optimization based on the reluctance circuit was taken, and the finite element methods (FEM) calculation results confirmed the theory analysis. Furthermore, a 30 kW/30 kHz IPT system based on this novel structure is measured as 85.3% at 30 kW power transfer across an air gap of 48 mm.
Pediatric Segmental Eccrine Spiradenomas: A Case Report and Review of the Literature

Abstract: Eccrine spiradenoma is a rare benign adnexal tumor that usually occurs as a solitary nodule, although there are reports of multiple eccrine spiradenomas occurring in a segmental, linear, blaschkoid, or zosteriform pattern. Segmental eccrine spiradenomas have rarely been reported with onset occurring in childhood or adolescence. We describe a case of segmental eccrine spiradenomas occurring on the neck and mandible of a child.
Use of Slow-Release Oral Morphine for the Treatment of Opioid Dependence

Aims: In addition to methadone, other synthetic opioids are now available for the treatment of opioid dependence. The study investigated the treatment satisfaction of oral slow-release morphine for maintenance therapy in opioid-dependent patients in an open-label 3-week study. Design: We evaluated the treatment satisfaction of oral slow-release morphine hydrochloride for 3 weeks in 110 patients meeting the diagnosis of opioid dependence (DSM-IV 304.0) or polysubstance dependence (DSM-IV 304.9). Measurements: Primary outcome measures were the study retention rate, urinalysis for additional illicit consumption other than heroin, cravings and withdrawal symptoms 24 h after the last intake of the medication (duration of action of treatment). Findings: In total, 103 patients completed the study, representing a retention rate of 94%. Patients reported significant improvements in somatic complaints, as well as significant reductions in heroin and cocaine cravings (p < 0.0001) and in additional consumption of cocaine in supervised urinalysis (p = 0.0083). Additional illicit consumption of benzodiazepines remained unchanged. Conclusions: The high study retention rate implies a good acceptance of slow-release acting oral morphine. However, randomised, double-blind, double-dummy studies with a longer investigational period are needed to meet criteria for evidence-based medicine.
An Array of Descending Visual Interneurons Encoding Self-Motion in Drosophila

The means by which brains transform sensory information into coherent motor actions is poorly understood. In flies, a relatively small set of descending interneurons are responsible for conveying sensory information and higher-order commands from the brain to motor circuits in the ventral nerve cord. Here, we describe three pairs of genetically identified descending interneurons that integrate information from wide-field visual interneurons and project directly to motor centers controlling flight behavior. We measured the physiological responses of these three cells during flight and found that they respond maximally to visual movement corresponding to rotation around three distinct body axes. After characterizing the tuning properties of an array of nine putative upstream visual interneurons, we show that simple linear combinations of their outputs can predict the responses of the three descending cells. Last, we developed a machine vision-tracking system that allows us to monitor multiple motor systems simultaneously and found that each visual descending interneuron class is correlated with a discrete set of motor programs. SIGNIFICANCE STATEMENT Most animals possess specialized sensory systems for encoding body rotation, which they use for stabilizing posture and regulating motor actions. In flies and other insects, the visual system contains an array of specialized neurons that integrate local optic flow to estimate body rotation during locomotion. However, the manner in which the output of these cells is transformed by the downstream neurons that innervate motor centers is poorly understood. We have identified a set of three visual descending neurons that integrate the output of nine large-field visual interneurons and project directly to flight motor centers. Our results provide new insight into how the sensory information that encodes body motion is transformed into a code that is appropriate for motor actions.
Investigation on Economic and Reliable Operation of Meshed MTDC/AC Grid as Impacted by Offshore Wind Farms

The influence of complementarity balancing connected grid and control of offshore wind power generation on the economic and reliable operation of hybrid multiterminal HVDC (MTDC) and AC power system is investigated in the paper. The variances of distribution curve of both transmission loss of AC/DC system and voltage of critical nodes assessed by cumulant-based method are used to demonstrate how the different complementarity conditions, generation balancing strategies, MTDC grid topologies, and control schemes affect power system operation. In this paper, a study case of 16-generator 68-bus power system connected with three offshore wind farms is presented. The variance indices of transmission loss and voltage magnitude are calculated and then compared under different complementarity levels, active power balancing strategies, HVDC transmission systems, and controls, respectively. The analysis reveals that higher complementarity and multi-machine balancing strategy can effectively reduce system operational cost and enhance operational reliability. Compared to the point-to-point topology, the control pattern and parameter setting of multi-terminal topology are two key factors to determine its impact on system operation.
Spinal cord injury‐induced lesional expression of the repulsive guidance molecule (RGM)

The repulsive guidance molecule (RGM) is involved in the formation of the central nervous system (CNS) during development by modulating guidance of growing axons. However, a role of RGM in CNS injury remains to be established. We studied the expression of RGM in the spinal cord of rats with spinal cord injury (SCI). After SCI, RGM+ cells accumulated in lesions and peri‐lesional areas. During the first days after SCI, RGM expression was confined to neurons, ballooned neurite fibers/retraction bulbs, smooth muscle/endothelial cells, and to leucocytes infiltrating the lesion. Lesional RGM expression was frequently confined to hypertrophic β‐APP+ and RhoA+ neurites/retraction bulbs. With maturation of the lesion, we observed RGM expression by components of the developing scar tissue (cicatrix), such as fibroblastoid cells, reactive astrocytes and in addition a pronounced extracellular RGM deposition resembling neo‐laminae. Frequent RGM+, RhoA+ coexpression by lesional retraction bulbs represent first preliminary evidence of RGM to exert growth inhibitory effects by the second messenger system RhoA. To date, RGM is one of the most potent axonal growth inhibitors identified and present in axonal growth impediments (i) oligodendrocytes; (ii) the plexus choroideus and (iii) components of the developing scar.
Hemispheric Contributions to Lexical Ambiguity Resolution: Evidence from Individuals with Complex Language Impairment Following Left-Hemisphere Lesions

Nine individuals with complex language deficits following left-hemisphere cortical lesions and a matched control group (n = 9) performed speeded lexical decisions on the third word of auditory word triplets containing a lexical ambiguity. The critical conditions were concordant (e.g., coin-bank-money), discordant (e.g., river-bank-money), neutral (e.g., day-bank-money), and unrelated (e.g., river-day-money). Triplets were presented with an interstimulus interval (ISI) of 100 and 1250 ms. Overall, the left-hemisphere-damaged subjects appeared able to exhaustively access meanings for lexical ambiguities rapidly, but were unable to reduce the level of activation for contextually inappropriate meanings at both short and long ISIs, unlike control subjects. These findings are consistent with a disruption of the proposed role of the left hemisphere in selecting and suppressing meanings via contextual integration and a sparing of the right-hemisphere mechanisms responsible for maintaining alternative meanings.
APHIDICIDAL ACTIVITY OF DIFFERENT AQUEOUS EXTRACTS OF BITTER APPLE CITRULLUS COLOCYNTHIS(L.) AGAINST THE BIRD CHERRY-OAT APHID, RHOPALOSIPHUM PADI(L.) (HOMOPTERA: APHIDIDAE) UNDER LABORATORY CONDITIONS

The impacts of aqueous extracts from different parts (root, stem , leaf and fruit) of bitter apple Citrullus colocynthis (Cucurbitales: Cucurbitaceae), with five different concentrations , on controlling the bird cherry-oat aphid, Rhopalosiphum padi (L.) (Homoptera: Aphididae) were investigated under laboratory conditions. Results showed that the effects of the aqueous extracts from different parts of C. colocynthis significantly differed in reducing R. padi numbers. The stem caused a higher mortality of R. padi, compared to other parts, in which the mortality percentages of R. padi were 75%, 71.25%, 60%, 43.75% and 40% respectively, when the aphids were treated with the aqueous extract of stem at 100000, 1000, 10, 0.1, 0.001 ppm, respectively. Also, toxicological parameters including LC50, LC90, toxicological index and slope of the toxicity lines showed that stems of C. colocynthis were more potent in controlling R. padi, compared to other parts. LC50 values of stem, root, leaf and fruit of C. colocynthis were 0.0002, 0.024, 0.043 and 0.055 ppm, respectively. Stem was revealed to be more effective than roo t by 0.83%, leaf by 0.47% and fruit by 0.36% for controlling R. padi. This could be justified to a higher amount of some toxicants in the stem such as terpenoids, cucurbitacin, glycosides, flavonoids and other compounds that may have a positive effect in controlling aphid pests. This study suggests that more detailed, long-term studies on both the chemistry of C. colocynthis and its effects on the pests’ natural enemies are required before recommending its use as an alternative to synthetic pesticides.