Miracle-dz/UniFAR-FTUs huggingface dataset:
2D Material Science: Defect Engineering by Particle Irradiation

Two-dimensional (2D) materials are at the heart of many novel devices due to their unique and often superior properties. For simplicity, 2D materials are often assumed to exist in their text-book form, i.e., as an ideal solid with no imperfections. However, defects are ubiquitous in macroscopic samples and play an important – if not imperative – role for the performance of any device. Thus, many independent studies have targeted the artificial introduction of defects into 2D materials by particle irradiation. In our view it would be beneficial to develop general defect engineering strategies for 2D materials based on a thorough understanding of the defect creation mechanisms, which may significantly vary from the ones relevant for 3D materials. This paper reviews the state-of-the-art in defect engineering of 2D materials by electron and ion irradiation with a clear focus on defect creation on the atomic scale and by individual impacts. Whenever possible we compile reported experimental data alongside corresponding theoretical studies. We show that, on the one hand, defect engineering by particle irradiation covers a wide range of defect types that can be fabricated with great precision in the most commonly investigated 2D materials. On the other hand, gaining a complete understanding still remains a challenge, that can be met by combining advanced theoretical methods and improved experimental set-ups, both of which only now begin to emerge. In conjunction with novel 2D materials, this challenge promises attractive future opportunities for researchers in this field.
A session‐specific opportunity cost model for rank‐oriented recommendation

Recommender systems are changing the way that people find information, products, and even other people. This paper studies the problem of leveraging the context of the items presented to the user in a user/system interaction session to improve the recommender system's ranking prediction. We propose a novel model that incorporates the opportunity cost of giving up the other items in the session and computes session‐specific relevance values for items for context‐aware recommendation. The model can work on a variety of different problems settings with emphasis on implicit user feedback as it supports varying levels of ordinal relevance. Experimental evaluation demonstrates the advantages of our new model with respect to the ranking quality.
Implementing a Postoperative Opioid-Prescribing Protocol Significantly Reduces the Total Morphine Milligram Equivalents Prescribed

Background: Opioid-prescribing patterns have been implicated as a contributing factor to the opioid epidemic, yet few evidence-based guidelines exist to assist health-care providers in assessing and possibly modifying their prescribing practices. Methods: Five orthopaedic hand surgeons at a level-I trauma center developed a postoperative prescribing guideline for 25 common hand and upper-extremity outpatient procedures, which were delineated into 5 tiers. Postoperative opioid prescriptions in a 3-month period after implementation of the protocol were compared with those from a 3-month period before implementation of the protocol. Results: There were 231 patients in the pre-implementation group and 287 patients in the post-implementation group. Each individual opioid protocol tier showed a significant decrease in the mean morphine milligram equivalents (MME) prescribed, ranging from a minimum decrease of 97.8% to a maximum decrease of 176.0%. After implementation, adherence to protocol was achieved in 55.1% of patients; the MME amounts prescribed were below protocol for 28.6% and above for 16.4%. The number of additional opioid prescriptions in the 1-month postoperative period was significantly less in the post-implementation group than in the pre-implementation group (p < 0.001). The total number of pills prescribed was reduced by a theoretical equivalent of over three thousand 5-mg oxycodone pills for the 287 patients in the 3-month period. Conclusions: By utilizing a simple consensus protocol, we have demonstrated success diminishing the number of opioids prescribed without leading to an increase in the number of secondary prescriptions written by our providers. These findings are encouraging and suggest that fewer opioids were left in the possession of patients, leaving fewer pills vulnerable to misuse, abuse, and diversion.
Advanced Simulation of Droplet Microfluidics

The complexity of droplet microfluidics grows with the implementation of parallel processes and multiple functionalities on a single device. This poses a severe challenge to the engineer designing the corresponding microfluidic networks. In today’s design processes, the engineer relies on calculations, assumptions, simplifications, as well as his/her experiences and intuitions. To validate the obtained specification of the microfluidic network, usually a prototype is fabricated and physical experiments are conducted thus far. In case the design does not implement the desired functionality, this prototyping iteration is repeated—obviously resulting in an expensive and time-consuming design process. To avoid unnecessary debugging loops involving fabrication and testing, simulation methods could help to initially validate the specification of the microfluidic network before any prototype is fabricated. However, state-of-the-art simulation tools come with severe limitations, which prevent their utilization for practically relevant applications. More precisely, they are often not dedicated to droplet microfluidics, cannot handle the required physical phenomena, are not publicly available, and can hardly be extended. In this work, we present an advanced simulation approach for droplet microfluidics that addresses these shortcomings and, eventually, allows simulating practically relevant applications. To this end, we propose a simulation framework at the one-dimensional analysis model, which directly works on the specification of the design, supports essential physical phenomena, is publicly available, and is easy to extend. Evaluations and case studies demonstrate the benefits of the proposed simulator: While current state-of-the-art tools were not applicable for practically relevant microfluidic networks, the proposed simulator allows reducing the design time and costs, e.g., of a drug screening device from one person month and USD 1200, respectively, to just a fraction of that.
Effects of neurofeedback versus methylphenidate for the treatment of attention-deficit/hyperactivity disorder protocol for a systematic review and meta-analysis of head-to-head trials

Introduction: Attention-deficit/hyperactivity disorder (ADHD) is developmental disorder characterized by inattention and/or hyperactivity/impulsivity. Psychostimulants, including methylphenidate (MPH), are recommended as a first-line pharmacological intervention, whereas neurofeedback (NF) has been proposed as a nonpharmacological option. The comparative effects of MPH and NF need further exploration. We will conduct a systematic review and meta-analysis of head-to-head randomized controlled trials (RCTs) comparing the efficacy and/or tolerability of MPH and NF in children/adolescents and adults with ADHD. Method and Analysis: We will include published as well as unpublished data. Two investigators will independently search PubMed, OVID, ERIC, Web of Science, ClinialTrials.gov, and a set of Chinese databases, including CNKI, CQVIP, and WanFang for head-to-head RCTs comparing MPH and NF. Experts will be contacted for unpublished data. The primary outcome will be the efficacy on ADHD core symptoms, measured by the change in the severity of ADHD symptoms, from baseline to endpoint and, if available, at follow-up (at any available time point). Secondary outcomes will be: dropouts for any reasons; efficacy on neuropsychological measures (working memory, inattention, and inhibition). We will conduct subgroup analyses to assess the impact of the following variables: age; type of NF; language of publication; comorbidities. Additionally, we will carry out meta-regression analyses to investigate the effect of sponsorship, year of publication, duration of intervention, and age of participants. Sensitivity analyses will be conducted to test the robustness of the findings. Risk of bias of individual studies will be assessed using the Cochrane risk of bias tool. Analyses will be performed using Comprehensive Meta-Analysis Software. Ethics and Dissemination: No ethical issues are foreseen. Results from this study will be published in a peer-reviewed journal and presented at relevant national and international conferences. Trials registration number: PROSPERO CRD42018090256.
Evaluation of the Team Workload Questionnaire (TWLQ) in a Team-Choice Task

Objective: The present study was designed to evaluate the team workload questionnaire (TWLQ) in a task that was distinct from the task used to create it. Background: The TWLQ was created from workload ratings generated by members of athletic sports teams. Given that such teams represent only a portion of the diversity of operational teams, we aimed to assess the generalizability of the TWLQ. Method: The present study applied the TWLQ in a collaborative choice task (hiring decision) to determine whether the factor structure reported in the initial publication of the scale would generalize from the execution tasks it was developed from to a disparate team task focused on consensus building. Results: Confirmatory factor analysis indicated that the present data (N = 144) were a poor fit for the three-factor structure of the TWLQ. Subsequent exploratory factor analysis revealed a much more interrelated model of team workload with no clear division between the three conceptual factors described in the original validation of the TWLQ. Conclusion: The factor structure of the TWLQ did not generalize to the present team-choice task. Application: Given that the duties of operational teams vary, it is critical that future research examine how the conceptual structure of team workload may be altered by task type.
Does military veteran status and deployment history impact officer involved shootings? A case-control study.

Background Despite veterans' preference hiring policies by law enforcement agencies, no studies have examined the nature or effects of military service or deployments on health outcomes. This study will examine the effect of military veteran status and deployment history on law enforcement officer (LEO)-involved shootings. Methods Ten years of data were extracted from Dallas Police Department records. LEOs who were involved in a shooting in the past 10 years were frequency matched on sex to LEOs never involved in a shooting. Military discharge records were examined to quantify veteran status and deployment(s). Multivariable logistic regression was used to estimate the effect of veteran status and deployment history on officer-involved shooting involvement. Results Records were abstracted for 516 officers. In the adjusted models, veteran LEOs who were not deployed were significantly more likely to be involved in a shooting than non-veteran officers. Veterans with a deployment history were 2.9 times more likely to be in a shooting than non-veteran officers. Conclusions Military veteran status, regardless of deployment history, is associated with increased odds of shootings among LEOs. Future studies should identify mechanisms that explain this relationship, and whether officers who experienced firsthand combat exposure experience greater odds of shooting involvement.
90th Anniversary Commentary: Diet Quality Indexes in Nutritional Epidemiology Inform Dietary Guidance and Public Health.

The 2012 article, “Alternative Dietary Indices Both Strongly Predict Risk of Chronic Disease,” in The Journal of Nutrition by Chiuve and colleagues (1) contributed to a rapidly growing literature on the connections between dietary patterns, as defined by food-based diet quality indexes, and health outcomes. The paper first presented a revised Alternative Healthy Eating Index-2010 (AHEI-2010), with modifications based on the most recent clinical research at that time, and then examined relations between both the Healthy Eating Index-2005 (HEI-2005) and AHEI-2010 with chronic disease risk (including cardiovascular disease, diabetes, cancer, or nontrauma death). The results showed that the HEI-2005 and the AHEI-2010 were associated with 16% and 19% significantly reduced risks of chronic disease comparing the highest with the lowest quintile of diet quality, respectively. These pivotal findings served to advance dietary patterns research and dietary guidance, and highlighted the need for analyses that modeled dietary patterns to reflect the total diet, rather than using only a single marker of intake such as 1 nutrient or dietary constituent.
Safe Cryptography for All: Toward Visual Metaphor Driven Cryptography Building Blocks

In this vision paper, we focus on a key aspect of the modern software developer's potential to write secure software: their (lack of) success in securely using cryptography APIs. In particular, we note that most ongoing research tends to focus on identifying concrete problems software developers experience, and providing workable solutions, but that such solutions still require developers to identify the appropriate API calls to make and, worse, to be familiar with and configure sometimes obscure parameters of such calls. In contrast, we envision identifying and employing targeted visual metaphors to allow developers to simply select the most appropriate cryptographic functionality they need.
Elastomeric Lumbar Total Disc Replacement: Clinical and Radiological Results With Minimum 84 Months Follow-Up

Abstract Background Total lumbar disc replacement (TDR) devices have been designed to maintain motion, but both biomechanical and clinical data have indicated that a more controlled motion and additional load absorption in TDR would be beneficial. This work analyzed long-term results of an elastomeric disc (Physio-L) for degenerative lumbar conditions. Material and Methods This was a prospective, noncomparative, single-center clinical and radiological study. A total of 15 patients with predominant low back pain due degenerative disc disease received anterior total disc replacement with a Physio-L disc. Clinical outcomes were assessed both with a visual analog scale for pain and Oswestry Disability Index questionnaires. Radiological outcomes included implant failure, range of motion (ROM), facet degeneration, and adjacent level disease. Complication and reoperation rates were also recorded. The cases were assessed with a minimum follow-up of 84 months. Results A total of 15 patients were enrolled (20 TDRs)—10 single-level cases (L5S1) and 5 two-level cases (L4L5/L5S1). After 84 months, clinical outcomes scores still demonstrated significant improvement compared with baseline (P < .001). Mean visual analog scale scores dropped from 7.1 to 2.9, and the Oswestry Disability Index improved from 50 to 16. No disc has experienced migration or breakage. The average range of motion value went from a baseline of 12.0° to 13.3° at 12 months, and at the final follow-up it decreased to 9.9°. Regarding the double-level cases, 3 of 5 (60%) had adverse events; just 1 single-level (10%) had adverse events. At final follow-up, radiological signs of facet degeneration were present in 7 of 15 patients (47%) but with only 1 of 15 (6.7%) symptomatic. Two patients (13%) required surgery at the adjacent level. At the 84-month follow-up, 16 of 18 prostheses (89%) were still active (2 revised to fusion and 2 were lost to follow-up). Conclusion The long-term follow-up data shows satisfactory clinical results for the use of Physio-L elastomeric TDR in the treatment of degenerative disc disease. Studies with bigger cohorts are needed to replicate results and add new information regarding other details.
Muscle Strength Variations of Knee Joint Muscles in Elite Female Handball Players after Pre-Season Conditioning

Abstract Monitoring seasonal variations in strength performance and the relative risk of injury indicators related to strength of hamstring (H) and quadriceps (Q) in female elite athletes is beneficial for the training process. The aim of this study was to examine and compare the level of muscle strength, the conventional ratio (HCONC/QCONC) as well as two functional and strength ratios reflecting the movement of knee extension (HECC/QCONC) and flexion (HCONC/QECC), and the bilateral percentage strength deficit (BSD) in elite female handball players. The concentric and eccentric isokinetic peak torque was measured at an angular velocity of 60°/s on three occasions (in-season cessation, 4 weeks of rest followed by 4 weeks of individual conditioning and 6 weeks of group conditioning) in eleven female handball players (age: 23.1 ± 3.5 years, body height: 1.73 ± 0.6 m). According to ANOVA results, the BSD of H muscles in the concentric mode decreased between the in-season cessation and the end of the pre-season, and HCONC/QCONC increased at the beginning of the pre-season and at the end of the pre-season in comparison with inseason cessation measurement. The effect size analyses showed that the off-season rest followed by 10 weeks of the conditioning programme increased Q and H strength in comparison with the previous season with a large effect. Coaches should include progressive conditioning in the pre-season phase to decrease the bilateral strength deficit and to support further conditioning development.
A Water-Soluble Extract from Actinidia arguta Ameliorates Psoriasis-Like Skin Inflammation in Mice by Inhibition of Neutrophil Infiltration

Psoriasis is a chronic inflammatory disease with complex etiology involving multiple factors. Current treatment methods are highly limited and there is a strong need for the development of safer and efficacious agents. We have previously shown that a water-soluble extract derived from hardy kiwifruit Actinidia arguta, called PG102, shows potent anti-inflammatory effects. Based on its reported biological activities, the effects of PG102 were examined on imiquimod-induced psoriasis-like skin inflammation. Our results showed that topical application of PG102 ameliorates clinical symptoms of psoriasis, reducing skin thickness and Interleukin (IL)-17A level in draining lymph nodes without causing any adverse effects. Treatment with PG102 on cytokine-stimulated HaCaT cells suppressed hyperproliferation and downregulated the expression of various chemokines and antimicrobial peptides known to induce neutrophil infiltration. These anti-inflammatory activities of PG102 were mediated via inhibition of NF-κB and signal transducer of activation (STAT) signaling. We also found decreased neutrophil chemotaxis both in vitro and in vivo. Taken together, PG102 has potential as a safe and effective reagent for the treatment of psoriasis.
Performance Comparison of some Synchronous Adders

This technical note compares the performance of some synchronous adders which correspond to the following architectures: i) ripple carry adder (RCA), ii) recursive carry lookahead adder (RCLA), iii) hybrid RCLA-RCA with the RCA used in the least significant adder bit positions, iv) block carry lookahead adder (BCLA), v) hybrid BCLA-RCA with the RCA used in the least significant adder bit positions, and vi) non-uniform input partitioned carry select adders (CSLAs) without and with the binary to excess-1 code (BEC) converter. The 32-bit addition was considered as an example operation. The adder architectures mentioned were implemented by targeting a typical case PVT specification (high threshold voltage, supply voltage of 1.05V and operating temperature of 25 degrees Celsius) of the Synopsys 32/28nm CMOS technology. The comparison leads to the following observations: i) the hybrid CCLA-RCA is preferable to the other adders in terms of the speed, the power-delay product, and the energy-delay product, ii) the non-uniform input partitioned CSLA without the BEC converter is preferable to the other adders in terms of the area-delay product, and iii) the RCA incorporating the full adder present in the standard digital cell library is preferable to the other adders in terms of the power-delay-area product.
Proof nets, coends and the Yoneda isomorphism

Proof nets provide permutation-independent representations of proofs and are used to investigate coherence problems for monoidal categories. We investigate a coherence problem concerning Second Order Multiplicative Linear Logic (MLL2), that is, the one of characterizing the equivalence over proofs generated by the interpretation of quantifiers by means of ends and coends. We provide a compact representation of proof nets for a fragment of MLL2 related to the Yoneda isomorphism. By adapting the "rewiring approach" used in coherence results for star-autonomous categories, we define an equivalence relation over proof nets called "re-witnessing". We prove that this relation characterizes, in this fragment, the equivalence generated by coends.
Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap–Core Interface of HIV-1 Protease

Four HIV-1 protease (PR) inhibitors, clinical inhibitors lopinavir and tipranavir, and two investigational compounds 4 and 5, were studied for their effect on the structure and activity of PR with drug-resistant mutation L76V (PRL76V). Compound 5 exhibited the best Ki value of 1.9 nM for PRL76V, whereas the other three inhibitors had Ki values of 4.5–7.6 nM, 2–3 orders of magnitude worse than for wild-type enzymes. Crystal structures showed only minor differences in interactions of inhibitors with PRL76V compared to wild-type complexes. The shorter side chain of Val76 in the mutant lost hydrophobic interactions with Lys45 and Ile47 in the flap, and with Asp30 and Thr74 in the protein core, consistent with decreased stability. Inhibitors forming additional polar interactions with the flaps or dimer interface of PRL76V were unable to compensate for the decrease in internal hydrophobic contacts. These structures provide insights for inhibitor design.
Serum NGAL and FGF23 may have certain value in early diagnosis of CIN

Abstract Aims: This study aimed to assess whether neutrophil gelatinase-associated lipocalin (NGAL) and fibroblast growth factor 23 (FGF23) could be reliable biomarkers for early diagnosis of contrast-induced nephropathy (CIN). Methods: 202 patients who underwent percutaneous coronary intervention (PCI) were included in the research. All subjects were divided into CIN group and non-CIN group. Serum NGAL and FGF23 were evaluated before and 0, 1, and 2 days after PCI. Serum levels of these two markers were compared intra-group and among groups. Receiver-operating characteristic (ROC) analysis and logistic regression models were conducted to assess the diagnostic performance of NGAL and FGF23 in detecting CIN. Results: When compared with baseline values, serum levels of both NGAL and FGF23 in all subjects increased after PCI, and the values peaked 1 day after PCI, but the changing was greater in CIN group. There were obvious differences between two groups in serum NGAL after 1, 2 days, and similar differences present in serum FGF23 after 1 day. ROC analysis showed that the area under the curve (AUC) of relative values (percent change from the baseline) in NGAL after 1 day was 0.899 (95% CI: 0.834–0.964, p = .000), the optimum cutoff was 49% (sensitivity = 80%, specificity = 92.4%). And the AUC in FGF23 was 0.814 (95% CI: 0.733–0.894, p = .000), the optimum cutoff was 20% (sensitivity = 73.3%, specificity = 87.6%). Both serum NGAL and serum FGF23 could improve the clinical models in identifying CIN. Conclusions: NGAL and FGF23 may have certain value in early diagnosis of CIN.