Miracle-dz/UniFAR-FTUs huggingface dataset:
Dosimetric comparison of intensity-modulated proton radiotherapy versus intensity-modulated photon-based radiotherapy for breast cancer

Purpose: This study aims to compare the dosimetric differences in intensity-modulated proton therapy (IMPT) using pencil beam scanning technology and intensity-modulated photon-based radiotherapy (IMRT) in hypofractionated whole-breast irradiation (HF-WBI) and find out the more beneficial technique. Methods and Materials: Eight breast cancer (BC) patients with pathological stage T1 ~ 2N0M0 were immobilized and underwent 4D-CT scanning used deep inspiration breath-hold (DIBH) technology. The IMPT and IMRT plans were designed for each patient. The IMPT plans used two en-face beam angles. IMRT plans were designed using the field in field technique. The optimization constraints of the two types of plans were identical. Prescription dose and regimen was 40.05 Gy (relative biological effect [RBE])/15 fx with a 10 Gy (RBE)/5 fx boost, five fractions a week. A dose of 95% of the target volume should not be less than the prescribed dose. The target coverage was evaluated using D1, D2, D50, D95, D98, and D99. The target dose distribution and conformity were evaluated using the Conformity index (CI) and the homogeneity index (HI). The Organs at risk (OARs) were evaluated using mean dose (Dmean) and maximum dose (Dmax). Ipsilateral Lung and Contralateral Lung were evaluated additionally using V5, V10, V20, V30. Results: The mean dose (Dmean) of the Heart (P = 0.012), Ipsilateral Lung (P = 0.036), Contralateral Lung (P = 0.012), and Spinal Cord (P = 0.012) were significantly reduced in IMPT plans. The IMPT also showed a tendency to reduce the V20 (P = 0.05) and V30 (P = 0.05) of the Ipsilateral Lung. But there was no significant difference in target coverage, homogeneity, and conformity between the IMRT and IMPT plans. Conclusion: Compared to IMRT, the IMPT using pencil beam scanning technology can spare OARs without compromising target coverage in BC patients undergoing HF-WBI, which potentially reduce the incidence of radiation-related adverse effects and thus may positively impact long-term survival.
Dental Pulp Stem Cells: an Alternative Source of Mesenchymal Stem Cells with Potential Osteogenic Regenerative Capacities

Background: Bone innate ability to repair without scaring is surpassed by major bone damage. Current gold-standard strategies do not achieve a full recovery of the bone biomechanical properties. To bypass these limitations, tissue engineering techniques based on hybrid materials made up of osteoprogenitor cells, like mesenchymal stem cells (MSCs), and bioactive ceramic scaffolds, like calcium phosphate-based (CaPs), are promising. Biological properties of the MSCs, including osteogenic potential, are influenced by the tissue source. The aim of this study is to define the MSC source and construct (MSC and scaffold combination) most interesting for its clinical application in the context of bone regeneration.Methods: MSCs of 9 healthy donors were isolated from adipose tissue, bone marrow and dental pulp. MSCs were cultured both on plastic surface and on CaPs (hydroxyapatite and β-tricalcium phosphate) to compare their biological features: proliferation rate, osteogenic potential, cell viability and activity, ability to colonize the CaPs and ALP activity. Results: iTRAQ results generated the hypothesis that anatomical proximity to bone has a direct effect on MSC phenotype. On plastic, MSCs isolated from dental pulp (DPSCs) were the MSCs with the highest proliferation capacity and the greatest osteogenic potential. On both CaPs, DPSCs are the MSCs with the greatest capacity to colonize bioceramics. Furthermore, results show a trend for DPSCs are the MSCs with the most robust increase in the ALP activity.Conclusion: Based in our results, we propose DPSCs as a suitable MSCs for bone/dental regeneration cell-based strategies.
Scoring environment pillar in environmental, social, and governance (ESG) assessment

ABSTRACT With technological advancements, many interconnected environmental issues have been worsening, including soil, water, and air pollution, climate change, loss of biodiversity, and over-exploitation of natural resources. With the inception of the term “sustainable development”, many market participants, including institutional and private investors, want to consider environmental sustainability in their investment decisions. However, until the upsurge of Environmental, Social, and Governance (ESG) investing, which is closely associated with sustainability, achieving sustainable development is challenging. ESG, the three critical areas identified by analysts, can significantly impact the financial aspect of a company. As a result, Renewable Energy 100%, the carbon neutrality approach, and the circular economy concept are widely used nowadays as environmental management tools. However, the limited comparability, the biased scoring metrics, the aggregated nature of diverse environmental factors, different methodologies implemented by rating providers, and the lack of robust datasets have resulted in limited usefulness of E (Environmental) scoring as a tool for greening the financial sector. Hence, to improve the relevance of the E pillar, the E in ESG must compose of a set of metrics to address different environmental aspects, thus avoiding unforeseen environmental disasters at a later stage. The inconsistency in the metrics’ scope and its evaluation criteria are the main drawbacks, which must be addressed for the E pillar to become an effective tool for allowing sustainable finance and development.
FOOD AND

Introduction : Inadequate fruit and vegetable (FV) consumption may derive from individual, cultural, socioeconomic, and environmental issues. Objective : This study aims to identify factors associated with inadequate fruit and vegetable consumption among men and women in Brazilian Primary Health Care. Methods : This is a cross-sectional study with a sample representative of the Health Academy Program (Programa Academia da Saúde-PAS, in Portuguese). The consumption of FV was evaluated by a validated questionnaire which included the frequency and number of portions consumed. The inadequate consumption was classified as fruits <3 servings/day; vegetables <2 servings/day.
The role of CYP19A1 and ESR2 gene polymorphisms in female androgenetic alopecia in the Polish population

Introduction Androgenetic alopecia is the most common type of non-cicatricial alopecia both in male and female patients. The mechanism that leads to hair loss is similar in both sexes, but the underlying cause, and especially the role of genes and sex hormones in the pathogenesis of the disease in women has not fully been explained as of yet. So far, a few attempts have been made to assess selected SNPs for CYP19A1 and ESR2 genes, but their results are not unequivocal and fully reproducible. Aim To investigate the association of 13 CYP19A1 and 11 ESR2 gene SNPs with female androgenetic alopecia (FAGA) in a population of Polish patients, including some already genotyped SNPs of possible importance for FAGA pathophysiology in other populations. Material and methods Twenty-four genetic polymorphisms were analysed for the ESR2 and CYP19A1 genes in 117 patients with FAGA and 128 healthy subjects treated at the Department of Dermatology in Krakow. Results In the studied Polish population, none of the selected SNPs, frequently detected in the Caucasian population and linked with the transformation pathway of sex hormones, showed a significant association with FAGA. Conclusions Further studies into the genetic background of androgenetic alopecia are needed. Ethnic differences as well as the size of the studied population may be of great significance for the obtained results.
Production of biodiesel from neem seed oil

Neem oil was extracted from neem seeds by mechanical extraction method. Yield of oil was 21.32%. The physicochemical properties of the extracted oil were studied in detail. The oil corresponds to diesel except acid value (14.21%) and sulphur content. Acid esterification was performed to reduce the acid value which was followed by transesterification to produce biodiesel. The conditions of the transesterification of the oil were optimized and were found to be 20% methanol and 1.0% NaOH at 60 ̊ C for 90 min. The optimum yield of biodiesel was 98 %. Finally, the performance study in a diesel engine was conducted with diesel and biodiesel blends. The brake thermal efficiency for 5% blend of biodiesel was 16.67% for brake power of 0.79 KW.Bangladesh J. Sci. Ind. Res.53(3), 211-218, 2018
In Depth Analysis of Photovoltaic Performance of Chlorophyll Derivative-Based “All Solid-State” Dye-Sensitized Solar Cells

Chlorophyll a derivatives were integrated in “all solid-state” dye sensitized solar cells (DSSCs) with a mesoporous TiO2 electrode and 2′,2′,7,7′-tetrakis[N,N-di(4-methoxyphenyl)amino]-9,9′-spirobifluorene as the hole-transport material. Despite modest power conversion efficiencies (PCEs) between 0.26% and 0.55% achieved for these chlorin dyes, a systematic investigation was carried out in order to elucidate their main limitations. To provide a comprehensive understanding of the parameters (structure, nature of the anchoring group, adsorption …) and their relationship with the PCEs, density functional theory (DFT) calculations, optical and photovoltaic studies and electron paramagnetic resonance analysis exploiting the 4-carboxy-TEMPO spin probe were combined. The recombination kinetics, the frontier molecular orbitals of these DSSCs and the adsorption efficiency onto the TiO2 surface were found to be the key parameters that govern their photovoltaic response.
Liouville-type theorem for higher-order Hardy-Hénon system

In this paper, we study higher-order Hardy-Hénon elliptic systems with weights. We first prove a new theorem on regularities of the positive solutions at the origin, then study equivalence between the higher-order Hardy-Hénon elliptic system and a proper integral system, and we obtain a new and interesting Liouville-type theorem by methods of moving planes and moving spheres for integral system. We also use this Liouville-type theorem to prove the Hénon-Lane-Emden conjecture for polyharmonic system under some conditions.
LINC01614 Promotes Osteosarcoma Progression as ceRNA to Target SNX3 by Sponging hsa-miR-520a-3p

Long noncoding RNAs (lncRNAs) have been reported as significant biomarkers for diagnosis and prognosis in osteosarcoma (OS), the most malignant bone tumor usually observed in children and adolescents. In the present study, we detected differentially expressed lncRNAs in three OS and paired adjacent tissues through RNA-seq technology. By comprehensively analyzing the expression profile and bioinformatics, we determined the relationship between noncoding RNA and OS-related functions, signal pathway, regulatory network, patient survival information and selected LINC01614 as the study object. Through related in vitro experiments, we confirmed that LINC01614 knockdown could inhibit the proliferation, invasion, and metastasis of OS cells. Furthermore, we used the luciferase reporter assay and qRT-PCR to confirm the regulatory relationship between LINC01614/hsa-miR-520a-3p/SNX3. We performed relevant in vitro experiments to prove that LINC01614 promotes the proliferation, invasion, and metastasis of OS cells through the LINC01614/hsa-miR-520a-3p/SNX3 axis. In conclusion, we identified that lncRNAs participate in various malignant behaviors in OS. We also proved that LINC01614 could function as competing endogenous RNAs and promote the proliferation, invasion, and metastasis of OS cells, and thus acts as a novel prognostic marker for OS in clinic.
DESAIN PROTOTIPE PADA STARTUP TALENTKU MENGGUNAKAN METODE LEAN UX STARTUP

Talentku is a market validation survey based on the user need to connect the students who have talent and want to hone their talents with companies/organizations that need talent for external and internal activities. The company needs a User Interface (UI) and User Experiences (UX) design as a base building platform. Strategies needed to design the UI/UX to run efective and efficient by prioritizing Just in Time Production. So the problem is how to design the UI/UX of my talent platform effectively and efficiently. The solution used to solve the above problem is designing User Interfaces and User Experiences using Lean UX Startup method. This method is pros "faster, smarter UX, research and learning". Results derived from this research is a prototype final that is a combination of prototype A and B that are validated in terms of criticism and suggestion through the questionnaire. The result of prototype A was selected for 13 featured, and prototype B was selected for 2 featured. Color scheme matching hexa #FE706E, as a branding form in the application Talentku and the font is Segoe UI.
Lysosomal or brush border enzymuria in kidney enzyme activities in seronegative rheumatoid arthritis

Introduction: To determine the effects of non-treated seronegative rheumatoid arthritis (RA) on proximal renal tubule, sensitivity of Alanine aminopeptidase (AAP), g-glutamyltransferase (g--GT), β2 microglobulin in urine β2M), as well as relation with rheumatoid factor (RF) and C-Reactive protein (CRP), DAS 28 disease activity index. Methods: RF was determined by agglutination test (Latex RF test, while kinetic methods were used for determination of Alanine aminopeptidase (AAP) and g-glutamyltransferase (g-GT), as well as MEIA (Micro particle Enzyme Immunoassay) to determine β2 microglobulin in urine. Samples (serum and urine) of 70 participants were examined (35 RA not treated, 35 health control group). Results: In 35 RF negative RA, AAP enzymuria was present in 12 (34.28%) patients, g-GT was present in 7 patients (20%), while β2 microglobulin was present in 3 patients (8.57%). In the healthy control group, 4 patients showed AAP positivity (11.42%), 2 patients g-GT positivity (5.71%) and 1 patient showed presence of β2 microglobulin in urine (2.85). RF was not present in any patient (0%). Conclusion: AAP has a higher sensitivity of g-GT and b2 microglobulin in the detection of asymptomatic renal lesions in non treated seronegative RA.
Fe3O4-GO composite as efficient heterogeneous photo-Fenton’s catalyst to degrade pesticides

Magnetic iron oxide (Fe3O4) and its composite with graphene oxide (Fe3O4-GO) were synthesized via ultrasonic-assisted co-precipitation method and characterized by Scanning Electron Microscopy, Fourier Transform Infrared spectroscopy and x-ray Diffraction techniques. These magnetic catalysts were investigated as heterogeneous photo-Fenton catalysts to degrade selected pesticides (carbofuran and nitenpyram) under UV light. The detailed parametric study explained that optimum catalyst dose and oxidant concentration were responsible for better catalytic degradation of pesticides. Degradation studies using magnetite alone was also performed in order to visualize the role of GO in catalysis. The composite Fe3O4-GO performed excellently in comparison to Fe3O4 for pesticides degradation. More than 90% degradation of nitenpyram and carbofuran were achieved. In order to have deep insight of the interaction between various process parameters, optimization through Response Surface Methodology (RSM) was studied for Fe3O4-GO. It has been found that no iron hydroxide sludge is formed when using Fe3O4-GO. Also the catalytic degradation could be reproduced in consecutive experiments without a significant loss in the process efficiency.
Traffic Operations and Capacity Analysis in India

This study highlights the concept of capacity analysis along with traffic operations in urban areas in India. First chapter indicates the introduction of this study through which research aims and objectives can be analysed properly. Moreover, research background and rationale of this study can be also highlighted in this chapter. The second chapter discusses the literature review due to which process of traffic operations and capacity analysis of vehicles can be analysed properly. Using model and theories of traffic flow can help in managing the complexities and issues in traffic management system in urban areas in India. The third chapter defines the research methodology through which tools and techniques regarding this research can be analysed successfully. Using philosophy, approach, design and data collection process, adequate information regarding traffic operations and capacity can be recognised properly.
Determination of sulfate in algal polysaccharide samples: a step-by-step protocol using microplate reader

Algal polysaccharides exhibit a wide range of biological activities and potential applications. Many of these bioactivities correlate positively with the presence of sulfate groups on the polysaccharides. The most common method used for sulfate quantification in algal samples is the turbidimetric method using the barium chloride-gelatin reagent. However, the original procedure is difficult to adapt for routine analysis since it is laborious and time-consuming. An optimized method was established using 96-well microplates, with the advantage of reducing waste and discrimination between organic and inorganic sulfates. This proposed method produced the same accuracy as the original.
Effect of educational nursing guideline about paracentesis procedure care on nurses' performance

Background: paracentesis is a common invasive method for managing patients with ascites; but it is associated with many potential complications. Nurses play a crucial role in preventing theses complications by providing special care before, during and after the procedures. Aim of the study: To evaluate the effect of educational nursing guideline about paracentesis procedure care on nurses' performance. Methodology: Research design: A pre/ posttest quasi-experimental research design was utilized in the present study. Sample: A convenient sample of (40) nurses was included in this study. Setting: The study was carried out at the tropical medicine departments of Qena University Hospital and Qena General Hospital, Qena governorate, Egypt. Tools of data collection: Two tools were utilized to collect data, First Tool: Structured interviewing questionnaire covered 2 parts: First part: Demographic data of the nurses. Second part included knowledge assessment sheet about paracentesis procedure. Second Tool: Observational checklist about paracentesis procedure. Study Duration: Data collection for this study was carried out through six months, from the beginning of January 2019 till the end of June 2019. Results: The study results revealed that there was a highly statistical improvement in total level of nurses' performance regarding paracentesis procedures at post and follow up phases after implementation of educational guidelines than before, with (p < 0.001). Conclusion: The application of educational nursing guidelines about paracentesis procedure enriched nurses' knowledge and practice than before. Recommendations: Continuous nursing education about paracentesis procedure is recommended to upgrade the knowledge and skills of nurses, replication of the current study on a larger probability sample from different geographical areas to achieve generalizable results.Also it is important to investigate the effect of applying this educational nursing guideline on ascetic patients' outcome.
Automated Software Testing of Deep Neural Network Programs

Machine Learning (ML) models play an essential role in various applications. Specifically, in recent years, Deep neural networks (DNN) are leveraged in a wide range of application domains. Given such growing applications, DNN models’ faults can raise concerns about its trustworthiness and may cause substantial losses. Therefore, detecting erroneous behaviours in any machine learning system, specially DNNs is critical. Software testing is a widely used mechanism to detect faults. However, since the exact output of most DNN models is not known for a given input data, traditional software testing techniques cannot be directly applied. In the last few years, several papers have proposed testing techniques and adequacy criteria for testing DNNs. This thesis studies three types of DNN testing techniques, using text and image input data. In the first technique, I use Multi Implementation Testing (MIT) to generate a test oracle for finding faulty DNN models. In the second experiment, I compare the best adequacy metrics from the coverage-based criteria (Surprise Adequacy) and the best example from mutation-based criteria (DeepMutation) in terms of their effectiveness for detecting adversarial examples. Finally, in the last experiment, I applied three different test generation techniques (including a novel technique) to the DNN models and compared their performance if the generated test data are used to re-train the models. The first experiment results indicate that using MIT as a test oracle can successfully detect the faulty programs. In the second study, the results indicate that although the mutation-based metric can show better performance in some experiments, it is sensitive to its parameters and requires hyper-parameter tuning. Finally, the last experiment shows a 17% improvement in terms of F1score, when using the proposed approach in this thesis compared to the original models from the literature.
Effects of Silane Debonder on the Properties of Fluff Pulp and the Study of Relevant Mechanism

The influence of silane debonder on the properties of fluff pulp fibers was investigated. The results showed that the burst index and internal bond strength of pulp sheet decreased with the increasing debonder loading. The density and zero-span tensile strength didn't change significantly when the debonder was added. The absorption capacity of fiber increased with increasing the de-bonder loading and achieved a maximum value of 10.3 g·g-1 when the debonder loading was 2.5%. The relevant mechanism was studied by X-ray Diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, and energy dispersive X-ray analysis (EDAX). XRD analysis indicated that the debonder had no great influence on the crystal structure of fiber. FT-IR analysis results showed that it was easier to break the intermolecular hydrogen bond than the intramolecular hydrogen bond with the incorporation of debonder. Therefore, the proportion of intramolecular hydrogen was increased. The EDAX results indicated that the debonder can decrease the binding force of fiber by shielding the hydroxyl groups and preventing the formation of hydrogen bonds.
Liquid Distribution and Mixing in Rotating Packed Beds

In this study, two different approaches for investigating micromixing in a rotating packed bed (RPB) with a Villermaux-Dushman protocol are presented and detailed information on the operation, design, and power consumption of the RPB is given. First, a novel nozzle liquid distribution design is investigated for micromixing. A structured approach for experimental investigations is introduced, and the influence of different liquid distribution parameters on the micromixing results is presented. It is shown that the outlet velocity from the nozzles and the liquid hold-up at the inner rim of the packing play a crucial role in the mixing process. Second, micromixing in RPBs with equal flow rates is investigated. A comparison with other continuous mixing devices is conducted based on flow rates, pressure drop, and the micromixing time parameter tm. It is demonstrated that RPBs show a large potential for fast mixing at high flow rates and low pressure drop.