Miracle-dz/UniFAR-FTUs huggingface dataset:
Let’s Read a Poem! What Type of Poetry Boosts Creativity?

Poetry is one of the most creative uses of language. Yet the influence of poetry on creativity has received little attention. The present research aimed to determine how the reception of different types of poetry affect creativity levels. In two experimental studies, participants were assigned to two conditions: poetry reading and non-poetic text reading. Participants read poems (Study 1 = narrative/open metaphors; Study 2 = descriptive/conventional metaphors) or control pieces of non-poetic text. Before and after the reading manipulation, participants were given a test to determine levels of divergent thinking (DT; i.e., fluency, flexibility, and originality). Additionally, in both studies, the impact of frequent contact with poetry was examined. In Study 1 (N = 107), participants showed increased fluency and flexibility after reading a narrative poem, while participants who read the non-poetic text showed a decrease in fluency and originality. In Study 2 (N = 131) reception of conventional, closed metaphorization significantly lowered fluency and flexibility of thinking (compared to reading non-poetic text). The most critical finding was that poetry exposure could either increase or decrease creativity level depending on the type of poetic metaphors and style of poetic narration. Furthermore, results indicate that long-term exposure to poetry is associated with creativity. This interest in poetry can be explained by an ability to immerse oneself in a poetry content (i.e., a type of empathy) and the need for cognitive stimulation. Thus, this paper contributes a new perspective on exposure to poetry in the context of creativity and discusses possible individual differences that may affect how this type of art is received. However, future research is necessary to examine these associations further.
Improving Subseasonal Forecasting in the Western U.S. with Machine Learning

Water managers in the western United States (U.S.) rely on longterm forecasts of temperature and precipitation to prepare for droughts and other wet weather extremes. To improve the accuracy of these longterm forecasts, the U.S. Bureau of Reclamation and the National Oceanic and Atmospheric Administration (NOAA) launched the Subseasonal Climate Forecast Rodeo, a year-long real-time forecasting challenge in which participants aimed to skillfully predict temperature and precipitation in the western U.S. two to four weeks and four to six weeks in advance. Here we present and evaluate our machine learning approach to the Rodeo and release our SubseasonalRodeo dataset, collected to train and evaluate our forecasting system. Our system is an ensemble of two nonlinear regression models. The first integrates the diverse collection of meteorological measurements and dynamic model forecasts in the SubseasonalRodeo dataset and prunes irrelevant predictors using a customized multitask feature selection procedure. The second uses only historical measurements of the target variable (temperature or precipitation) and introduces multitask nearest neighbor features into a weighted local linear regression. Each model alone is significantly more accurate than the debiased operational U.S. Climate Forecasting System (CFSv2), and our ensemble skill exceeds that of the top Rodeo competitor for each target variable and forecast horizon. Moreover, over 2011-2018, an ensemble of our regression models and debiased CFSv2 improves debiased CFSv2 skill by 40-50% for temperature and 129-169% for precipitation. We hope that both our dataset and our methods will help to advance the state of the art in subseasonal forecasting.
A Practical PIR-based Scheme for Discovering Nearby Places for Smartphone Applications

We present a privacy-preserving approach for discovering nearby places of interest to Alice. In this approach, the proposed protocol allows Alice to learn whether there is any place that she is looking for near her. However, the location-based service (LBS) that tries to help Alice to find nearby places does not learn Alice’s location. Alice can send a request to the LBS database to retrieve nearby places of interest (POIs) without the database becoming aware of what Alice fetched by using private information retrieval (PIR). The common criticism of previous PIR approaches is that they are not practical for smartphones with limited processing power, memory, and wireless bandwidth due to the computational overhead. Therefore, the main focus of this work is to propose a scheme to reduce the computation cost on the client-side to make PIR appropriate and practical for the smartphone environments, and then apply the proposed PIR to LBS applications. We have implemented our protocol in Percy++ to evaluate its performance over a commercial-grade database of POIs. Our implementation results demonstrate that our approach has faster decode and retrieve time for the nearby POIs on smartphones compared with current similar work.
Effects of a specially designed aerobic dance routine on mild cognitive impairment

Background Mild cognitive impairment (MCI) is known as a transitional stage or phase between normal aging and dementia. In addition, it is associated with an increased risk of dementia. Research has shown that moderate-intensity exercise is associated with a decreased risk of cognitive impairment. Two recent studies demonstrated that dance interventions are associated with improved cognitive function in the elderly with MCI. Purpose We evaluated the effect of a moderate-intensity aerobic dance routine on the cognitive function in patients with MCI. Patients and methods This is a single-blind randomized controlled trial. Sixty MCI patients were randomized to receive either treatment (aerobic dance routine + usual care) or control (usual care only) for 3 months. All patients received usual care for an additional 3 months thereafter. The aerobic dance routine was a specially designed dance routine which involved cognitive effort for patients to memorize the complex movements. Wechsler memory scale-revised logical memory (WMS-R LM) and event-related evoked potentials (ERPs) P300 latency were used to assess patients’ cognitive function at baseline, 3 months, and 6 months. Results Twenty-nine patients received exercise therapy and 31 patients received usual care. Patients in the treatment group showed a greater improvement in memory (difference in WMS-R LM changes over 3 months 4.6; 95% CI 2.2, 7.0; p<0.001) and processing speed (difference in P300 latency changes over 6 months −20.0; 95% CI=−39.5, −0.4; p<0.05) compared to control. Conclusion This dance routine improves cognitive function, especially episodic memory and processing speed, in MCI patients and merits promotion in communities.
Validation and calibration of self-reported height and weight in the Danish Health Examination Survey

BACKGROUND Body mass index (BMI) derived from self-reported information is widely used and the validity is therefore crucial. We aim at testing the validity of self-reported height and weight, and to test if the accuracy of self-reported information can be improved by calibration by testing if calibration improved the ability to predict diabetes. METHODS Data from Danish Health Examination Survey (DANHES) was used. 15 692 participants who had both filled out questionnaire and participated in health examination, and 54 725 participants with questionnaire alone, were included. Data was analyzed using Pearson's R, Cohens Kappa, linear regression and Cox-regression. Self-reported values of height and weight were calibrated using coefficients obtained from linear regression analysis. To evaluate if the calibration improved the ability to predict diabetes, Akaike's information criterion was used. RESULTS Self-reported height, weight and BMI were highly correlated with measured values (R ≥ 0.92). BMI was under-reported by 0.32 kg m-2 and 0.38 kg m-2 in women and men. The hazard ratio (HR) (95% confidence interval) for diabetes according to measured BMI was 2.09 (1.89-2.27) and for self-reported BMI was 1.60 (1.50-1.70) per 5 kg m-2. Calibrated values of self-reported BMI improved the predictive value of BMI for the risk of diabetes. CONCLUSIONS Self-reported height and weight correlated highly with physical measurement of height and weight. Measured values of BMI were more strongly associated with diabetes risk as compared to self-reported values. Calibration of the self-reported values improved the accuracy of self-reported height and weight.
Absence of natriuretic peptide clearance receptor attenuates TGF-&bgr;1-induced selective atrial fibrosis and atrial fibrillation

Aims TGF-β1 plays an important role in atrial fibrosis and atrial fibrillation (AF); previous studies have shown that the atria are more susceptible to TGF-β1 mediated fibrosis than the ventricles. Natriuretic peptides (NPs) play an important role in cardiac remodelling and fibrosis, but the role of natriuretic peptide clearance (NPR-C) receptor is largely unknown. We investigated the role of NPR-C in modulating TGF-β1 signalling in the atria. Methods and results MHC-TGF-β1 transgenic (TGF-β1-Tx) mice, which develop isolated atrial fibrosis and AF, were cross-bred with NPR-C knock-out mice (NPR-C-KO). Transverse aortic constriction (TAC) was performed in wild type (Wt) and NPR-C knockout mice to study. Atrial fibrosis and AF inducibility in a pathophysiologic model. Electrophysiology, molecular, and histologic studies were performed in adult mice. siRNA was used to interrogate the interaction between TGF-β1 and NP signalling pathways in isolated atrial and ventricular fibroblasts/myofibroblasts. NPR-C expression level was 17 ± 5.8-fold higher in the atria compared with the ventricle in Wt mice (P = 0.009). Cross-bred mice demonstrated markedly decreased pSmad2 and collagen expression, atrial fibrosis, and AF compared with TGF-β1-Tx mice with intact NPR-C. There was a marked reduction in atrial fibrosis gene expression and AF inducibility in the NPR-C-KO-TAC mice compared with Wt-TAC. In isolated fibroblasts, knockdown of NPR-C resulted in a marked reduction of pSmad2 (56 ± 4% and 24 ± 14% reduction in atrial and ventricular fibroblasts, respectively) and collagen (76 ± 15% and 35 ± 23% reduction in atrial and ventricular fibroblasts/myofibroblasts, respectively) in response to TGF-β1 stimulation. This effect was reversed by simultaneously knocking down NPR-A but not with simultaneous knock down of PKG-1. Conclusion The differential response to TGF-β1 stimulated fibrosis between the atria and ventricle are in part mediated by the abundance of NPR-C receptors in the atria.
Hepcidin‐25/erythroferrone ratio predicts improvement of anaemia in haemodialysis patients treated with ferric citrate hydrate

Hepcidin‐25 (HEP‐25) and erythroferrone (ERFE) are key regulators of iron homeostasis. Correlations among serum ferritin, ERFE and HEP‐25 levels and improvements in anaemia have not been evaluated after administration of ferric citrate hydrate (FCH).
Iturin A‐like lipopeptides from Bacillus subtilis trigger apoptosis, paraptosis, and autophagy in Caco‐2 cells

This study revealed that iturin A‐like lipopeptides produced by Bacillus subtillis induced both paraptosis and apoptosis in heterogeneous human epithelial colorectal adenocarcinoma (Caco‐2) cells. Autophagy was simultaneously induced in Caco‐2 cells treated with iturin A‐like lipopeptides at the early stage and inhibited at the later stage. A western blot analysis showed that the lipopeptides induced apoptosis in Caco‐2 cells via a mitochondrial‐dependent pathway, as indicated by upregulated expression of the apoptotic genes bax and bad and downregulated expression of the antiapoptotic gene bcl‐2. The induction of paraptosis in Caco‐2 cells was indicated by the occurrence of many cytoplasmic vacuoles accompanied by endoplasmic reticulum (ER) dilatation and mitochondrial swelling and dysfunction. ER stress also occurred with significant increases in reactive oxygen species and Ca2+ levels in cells. Autophagy was detected by a transmission electron microscopy analysis and by upregulated expression of LC3‐II and downregulated expression of LC3‐I. The inhibition of autophagy at the later stage was shown by upregulated expression of p62. This study revealed the capability of iturin A‐like B. subtilis lipopeptides to simultaneously execute antitumor potential via multiple pathways.
Production of 15O for Medical Applications via the 16O(γ,n)15O Reaction

15O (half-life, 122 s) is a useful radionuclide for PET applications. Current production of 15O typically makes use of the 14N(d,n)15O, 15N(p,n)15O, or 16O(p,pn)15O reactions using an accelerator. A novel approach for the production of 15O is via the 16O(γ,n)15O reaction using an electron linear accelerator. Photonuclear reactions using an electron linear accelerator may allow for feasible and economical production of 15O compared with the current methods. Methods: In this work, experiments using a repurposed Clinac were conducted using oxygen-containing alumina as a target material to study the production rate of 15O. Additional studies were conducted using a water target cell. Simulations using Geant4 were conducted to predict the activity and power dissipation in the target. Results: Bremsstrahlung radiation from the electron beam, and consequently 15O production via photonuclear reactions, is enhanced when a high-Z material, tungsten, is placed in front of the target. The alumina irradiations provided preliminary data to optimize the beam parameters and target configuration. The optimal thickness of tungsten was 1.4 mm for both the simulated and the measured studies of alumina. Simulations of irradiated water targets showed that tungsten thicker than 1.4 mm resulted in fewer photons available to activate the water; thus, a higher current was required to achieve a fixed dose. Alternatively, for a constant tungsten thickness, more power was deposited in the target with increasing beam energy, requiring a lower current to achieve a fixed dose. Actual irradiations of a water target yielded a quantity of 15O in the water that was consistent with expectations based on irradiations of alumina. Conclusion: Several parameters should be considered regarding the photonuclear production of 15O for an average patient dose of 1,850 MBq (50 mCi) in 10 mL. This work illustrates a variety of machine parameters capable of achieving a reasonable patient dose. Our simulations show that the power deposited in the target for these parameters is less than that in commercially operated cyclotron targets for the production of 18F. Thus, this work demonstrates that the photonuclear production of 15O may be a new production path for this useful radionuclide.
Wernicke Encephalopathy Due to Hyperemesis Gravidarum in Pregnancy: A Case Report

Wernicke’s encephalopathy (WE) is a life-threatening acute or sub-acute neurological emergency characterized by ataxia, confusion, nystagmus, and ophthalmoparesis caused by thiamine deficiency. It was first described in 1881 by Carl Wernicke with alcohol being the most common cause. We present a rare case of a 35-year-old pregnant female who presented to our emergency department with a history of vomiting and loose motions for two weeks. She later developed fever, confusion, slurred speech and blurring of vision. Magnetic resonance imaging (MRI) of the brain revealed typical lesions of WE. She was immediately treated with thiamine and her symptoms improved in a few days.
Fully Distributed Cooperation for Networked Uncertain Mobile Manipulators

This article investigates a fully distributed cooperation scheme for networked mobile manipulators. To achieve cooperative task allocation in a distributed way, an adaptation-based estimation law is established for each robotic agent to estimate the desired local trajectory. In addition, wrench synthesis is analyzed in detail to lay a solid foundation for tight cooperation tasks. Together with the estimated task, a set of distributed adaptive (DA) controllers is proposed to achieve motion synchronization of the mobile manipulator ensemble over a directed graph with a spanning tree irrespective of the kinematic and dynamic uncertainties in both the mobile manipulators and the tightly grasped object. The controlled synchronization alleviates the performance degradation caused by the estimation/tracking discrepancy during the transient phase. The proposed scheme requires no persistent excitation condition and avoids the use of noisy Cartesian-space velocities. Furthermore, it is independent from the object's center of mass by employing formation-based task allocation and a task-oriented strategy. These attractive attributes facilitate the practical application of the scheme. It is theoretically proven that convergence of the cooperative task tracking error is guaranteed. Simulation results, as well as manipulation experiments with three mobile manipulators involved, validate the efficacy and demonstrate the expected performance of the proposed scheme.
Score for lung adenocarcinoma in China with EGFR mutation of exon 19

Backgroud: The biopsy samples might be the only tumor material available for testing the EGFR mutation status in some cases, but these samples are often composed of variable ratios of tumor to normal cells. In this study, we sought to build a scoring system to predict Epidermal growth factor receptor (EGFR) exon 19 mutation in lung adenocarcinoma by clinical and radiological features. Methods: Enrolled in this study were 601 patients with lung adenocarcinoma. Qualitative evaluation of the clinical and radiological features included 25 aspects. Statistical analysis was used to assess the association of these features between the EGFR wild type and exon 19 mutation, based on a clinical scoring system built by the statistical model and the experience of the radiologists. Results: EGRF-exon-19-mutation was associated with the female gender [odds ratios (OR), 2.573; 95% confidence intervals (CI), 1.689–3.920], tumor maximum diameter (OR, 0.357; 95% CI, 0.235–0.542), the absence of emphysema (OR, 0.202; 95% CI, 0.110–0.368), the absence of fibrosis (OR, 0.168; 95% CI, 0.083–0.339), and pleural retraction (OR, 2.170; 95% CI, 1.434–3.285). The clinical scoring model assigned 3 points to the female gender, 2 points to small tumor maximum diameter (⩽34.5 mm), 2 to the absence of emphysema, 2 to the absence of fibrosis, and 1 to the presence of pleural retraction. Conclusions: The scoring system based on the statistical analysis of clinical and radiological features may be a new alternative to the prediction of EGFR mutation subtypes.
Psychometric properties of the Clinical Outcome Routine Evaluation‐Learning Disabilities 30‐Item (CORE‐LD30)

BACKGROUND There is paucity in availability of valid and reliable measures of psychopathology that can be routinely applied with an intellectual disability (ID) population in clinical practice. The psychometric properties of the Clinical Outcome Routine Evaluation-Learning Disabilities 30-Item version (CORE-LD30) are examined. METHOD The CORE-LD30 was administered to 271 sequential referrals to three National Health Service (NHS) ID services providing psychological support. A principal components analysis with oblique rotation was conducted with examination of convergent validity for extracted domains. RESULTS Three rotated factors were extracted with good levels of internal consistency reported for the overall measure (α = 0.92) and each of the domains, conceptually labelled Problems/Symptoms (α = 0.90), Risk to Self (α = 0.76) and Risk to Others (α = 0.71). Convergent validity is reported for two domains [Problems/Symptoms with the Glasgow Depression Scale for people with a learning disability (LD) and Risk to Others with the Health of the Nation Outcome Scale-LD], and support for the CORE-LD30 as a 'core' measure indicated. CONCLUSIONS The CORE-LD30 is recommended as a useful broad ranging measure of psychopathology for use with an ID population. Domains may prove to be useful for research and clinical purposes. Further research is recommended to examine the ability to monitor clinical change associated with specific levels of presentation and different clinical presentations/cohorts.
Investigating effective treatment factors in brief cognitive behavioral therapy for panic disorder

Abstract Numerous studies have provided evidence for the effectiveness of cognitive behavioral therapy (CBT) on panic disorders (PDs). There has also been growing attention on brief CBT with regard to delivering intensive treatment efficiently. This study investigated the essential parts of mindfulness-based brief CBT to optimize treatment benefits. A total of 37 patients were retrospectively enrolled in this study. They were recruited from the anxiety/panic/fear clinic of Seoul National University Hospital. The patients participated in group CBT once a week for a total of 4 sessions over a 4-week period, when they were assessed using the Panic Disorder Severity Scale (PDSS), Anxiety Sensitivity Index-Revised (ASI-R), Albany Panic and Phobia Questionnaire (APPQ), State-Trait Anxiety Inventory (STAI), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and Yale-Brown Obsessive Compulsive Scale (Y-BOCS) before and after brief CBT. Twenty-nine patients completed the 1-month follow-up. There were significant reductions in PDSS (P < .001), ASI-R-fear of respiratory symptoms (P = .006), ASI-R-fear of publicly observable anxiety reaction (P = .002), ASI-R-fear of cardiovascular symptoms (P < .001), ASI-R-fear of cognitive dyscontrol (P = .001), ASI-R-Total (P < .001), APPQ-Agoraphobia (P = .003), APPQ-Total (P = .028), STAI-State anxiety (P < .001), STAI-Trait anxiety (P = .002), BAI (P = .003), and BDI (P < .001) scores. We also found significant associations between ASI-R-fear of cardiovascular symptoms, ASI-R-Total, and changes in PDSS scores. A stepwise multiple linear regression analysis indicated that anxiety sensitivity for fear of cardiovascular symptoms predicted an improvement in panic severity (&bgr; = 0.513, P = .004). Our findings suggested that behavioral aspects, especially physiological symptom control, needed to be considered in brief, intensive CBT for PD. The results also suggested that a mindfulness-based brief CBT approach might be particularly helpful for patients with PD who have severe cardiovascular symptoms.