Miracle-dz/UniFAR-FTUs huggingface dataset:
Weekly alternate intensive regimen FIrB/FOx in metastatic colorectal cancer patients: an update from clinical practice

Background Several trials evaluated the role of intensive regimens, made of triplet chemotherapies plus bevacizumab, as first-line treatment for patients with metastatic colorectal cancer (mCRC). We previously reported, in a Phase II prospective study, the efficacy and the tolerability of FIrB/FOx regimen, reporting interesting results in terms of received dose intensities (rDIs) and safety. Methods We reported a retrospective update of 85 patients treated with FIrB/FOx, an intensive regimen of 5-fluorouracil, bevacizumab, and weekly alternate irinotecan and oxaliplatin, to confirm its feasibility in “real life”. Subgroup analyses were performed, particularly among patients treated with standard and modified FIrB/FOx (based on age, performance status, and/or comorbidities). Results Overall, 3-month objective response rate (ORR) and 6-month ORR were 75.9% and 55.3%, respectively. Median progression-free survival (PFS) and median overall survival (OS) were 14.4 and 34.9 months, respectively. Among the patients treated with standard and modified regimens, 3-month ORR, PFS, and OS were 75.8% and 76% (P=1.0000), 14.4 and 14.4 months (P=0.8589), and 37.8 and 26.6 months (P=0.7746), respectively. Among the K/NRAS wild-type and K/NRAS mutant patients, 3-month ORR, PFS, and OS were 95.2% and 74.5% (P=0.0526), 15.3 and 14.4 months (P=0.8753), and 37.8 and 51.4 months (P=0.8527), respectively. The rDIs were ≥80% of full doses both in the standard and in the modified regimens subgroups. Cumulative G3/4 toxicities were neutropenia (14.1%), diarrhea (17.6%), asthenia (9.4%), vomiting (5.6%), and hypertension (16.5%). Conclusion This update shows that intensive regimens such as FIrB/FOx are also feasible options for first-line treatment of mCRC patients in the “real-life” setting.
influence of relationship marketing on customer loyalty

This study aims to examine and explain the effect of relationship marketing on customer loyalty mediated by customer satisfaction. To achieve the research objectives, data analysis using Path Analysis and Sobel Test. Sampling by non-probability sampling with purposive sampling method and the size of the sample taken is 120 respondents. The results of the analysis show that relationship marketing has a positive and significant effect on customer loyalty at Livingstone Café & Bakery Seminyak Bali. Furthermore, relationship marketing also has a positive and significant effect on customer satisfaction at Livingstone Café & Bakery Seminyak Bali. Customer satisfaction has a positive and significant effect on customer loyalty at Livingstone Café & Bakery Seminyak Bali and customer satisfaction can significantly mediate the effect of relationship marketing on customer loyalty at Livingstone Cafe & Bakery Seminyak Bali. Suggestions that can be recommended to the management of Livingstone Café & Bakery Seminyak Bali are to always build better relationship marketing to increase customer satisfaction and customer loyalty.
Analysis of renewable energy sources and a heat storage tank application in a district heating substation

The study verifies the potential application of renewable energy sources in a district heating substation. Different operating configurations of heat sources have been analysed, including solar collectors, PV panels and air source heat pump. Concepts of regulating the water parameters in a substation have been analysed. Moreover, the potential impact of a heat storage tank application has been calculated using a genetic algorithm to find optimal operating conditions in a district heating substation. The analysis is based on measured yearly data.
Location Determination and Tracking Using Radio Beacons

Location awareness is an important capability for a series of wirelessly-enhanced business and consumer mobile applications. Low-cost devices that can be incorporated into a broad range of business and consumer appliances can be used for location determination and tracking. In this paper, we demonstrate a radio beacon-based approach that suggests heterogeneous wireless networks can be joined together to provide wide area tracking capability. Our implementation is based on probabilistic and statistical techniques, where signal strengths measurements from cellular networks are used to estimate the user's location. Simulation results and field tests around Lancaster University campus show that these techniques can achieve good performance (accuracy less than 50 m) compared with traditional deterministic methods (i.e. triangulation).
Collaborative Aerial-Drawing System for Supporting Co-Creative Communication

This paper describes the collaborative augmented reality (AR) system with which multiple users can handwrite 3D lines in the air simultaneously and manipulate the lines directly in the real world. In addition, we propose a new technique for co-creative communication utilizing the 3D drawing activity. Up to now, the various 3D user interfaces have been proposed. Although most of them aim to solve the specific problems in the virtual environments, the possibility of the 3D drawing expression has not been explored yet. Accordingly, we paid special attention to the interaction with the real objects in daily life, and considered to manipulate real objects and 3D lines without any distinctions by the same action. The developed AR system consists of a stereoscopic head-mounted display, a drawing tool, 6DOF sensors measuring three-dimensional position and Euler angles, and the 3D user interface, which enables to push, grasp and pitch 3D lines directly by use of the drawing tool. Additionally users can pick up desired color from either a landscape or a virtual line through the direct interaction with this tool. For sharing 3D lines among multiple users at the same place, the distributed-type AR system has been developed that mutually sends and receives drawn data between systems. With the developed system, users can proceed to design jointly in the real space through arranging each 3D drawing by direct manipulation. Moreover, a new application to the entertainment has become possible to play sports like catch, fencing match, or the like.
Biological Activity Evaluation and In Silico Studies of Polyprenylated Benzophenones from Garcinia celebica

This study aimed to isolate polyprenylated benzophenones from the rootbark of Garcinia celebica and assess their activities in vitro and in silico. The antioxidant activity was evaluated by the DPPH, ABTS, and FRAP methods. The cytotoxicity was evaluated against HeLa, MCF-7, A549, and B16 cancer cell lines. The antiplasmodial activity was performed against the chloroquine-sensitive Plasmodium falciparum strain 3D7. Molecular docking was analyzed on alpha-estrogen receptor (3ERT) and P. falciparum lactate dehydrogenase enzyme (1CET). The prediction of ADMET for the compounds was also studied. For the first time, (-)-cycloxanthochymol, isoxanthochymol, and xanthochymol were isolated from the root bark of Garcinia celebica. The antioxidant and cytotoxicity evaluation showed that all benzophenones exhibited antioxidant activity compared to gallic acid and quercetin as positive controls and also exhibited strong activity against HeLa, MCF-7, A549, and B16 cell lines compared to cisplatin as the positive control. The antiplasmodial evaluation showed that isoxanthochymol exhibited activity against the chloroquine-sensitive P. falciparum strain 3D7. In addition, the in silico molecular docking study supported in vitro activities. The ADMET analysis also indicated the isolated benzophenones are potential oral drug candidates.
High load limits of the controlled autoignition engine

The controlled autoignition (CAI) engine is an engine concept that features very low soot and NOx emissions while achieving diesel-like efficiency. The CAI combustion process is characterized by a fast, volumetric burn of a premixed fuel and air mixture that is heavily diluted with either excess air or burned gas. One problem that limits the engine's introduction into the market is that the rate of combustion can be fast to the point that it is very loud and is destructive to the mechanical components of the engine. The nature of this problem is akin to spark-ignition knock and presents a high-load limit to the operating range. Misfire presents a second high-load limit. This work seeks to understand how various engine parameters affect the high-load knock limit and the high-load misfire limit of a CAI engine operating in the negative-valve-overlap mode. Valve timing, and therefore trapped residual gas fraction, turbocharging, intake air heating, and exhaust gas recirculation (EGR) are all explored for their effects on the high load limit. A singlecylinder research engine is used to assess each of these effects. 91 RON gasoline is used for all tests. The first part of the study explores the effects of boost, intake air temperature, and trapped residual fraction on the rate of pressure rise, which was used as the metric for knock, and on NIMEP. It was shown that if operation is constrained by maximum pressure rise rate (PRRmax), the maximum load condition always lies at the misfire limit. The dependencies of misfire on boost, intake air temperature, and residual fraction were also explored. The second part of the study examined how the use of EGR affected the high-load limit. Again, the high-load limit, constrained by maximum pressure rise rate, was maximized at the misfire limit. Varying boost and intake temperature did not materially change the high load limit because the misfire limit and the PRRmax changed simultaneously in such a way that the NIMEP at the new limit point did not change appreciably from the original value. Correlations were developed for the misfire limit, for the burn duration, and for combustion phasing. Thesis Supervisor: Wai K. Cheng Title: Professor of Mechanical Engineering (This page was intentionally left blank.)
Subsoil Heat Exchangers for the Air Conditioning of Livestock Buildings

Abstract Subsoil heat exchangers have the potential to improve ambient conditions in livestock buildings, especially in piggeries. However, the general characteristics of an optimal installation are not well known. A three-dimensional non-steady-state heat flow model was developed in order to simulate the heat transfer between the air circulating in the tubes and the surrounding ground. By combining the results of this heat flow model with those of an experimental subsoil heat exchanger, it was possible to study the influence of various parameters, such as the type of ground and the air speed, as well as the characteristics of the pipes (diameter, length, depth and spacing), on the efficiency of heat exchange. This computer model constitutes an efficient tool to optimize the geometry of the pipes in order to find the ideal compromise between cost and thermal efficiency.
Numerical simulation of the effect of LPG blending on the characteristics of a diesel engine

The present work aims to investigate numerically the effect of LPG blending on the characteristics of diesel engines subjected to variable compression ratio, injection timing, and engine speed. Three blends of LPG are used, which are 10% LPG + 90% diesel, 20% LPG + 80% diesel, and 30% LPG + 70% diesel. The numerical investigation is carried out using the simulation software Diesel‐RK. Increasing the percentage of LPG in diesel starts combustion early where the lowest delay period is recorded for a blend of 30% LPG + 70% diesel 6.36 deg. The combustion pressure and heat release are decreased due to the difference in the heating values of blended fuels. Although the peak energy release for diesel is 0.05458 (1/deg.) at 375 deg. BTDC, it was 0.0542, 0.05424, and 0.0537 (1/deg.) at 375 deg. BTDC for 10%, 20%, 30% LPG, respectively. Diesel with 30% LPG has a higher spray penetration followed by 20% LPG then 10% LPG and diesel come last. The diesel with 10% LPG gives a 5.35% reduction in NOx, while diesel with 20% and 30% LPG emit less NOx emission by 9.05% and 16.5%, respectively. Increasing the percentage of LPG in diesel yields to reduce soot concentration because LPG has lower carbon to hydrogen ratio. The lowest ability to emit smoke is detected for fuel with 30% LPG where a 7.4% reduction is obtained. It is worth noting that blending LPG with diesel can fight the trade‐off relation between Soot‐NOx as a reduction in both of them is obtained. Based on the results obtained, the blending ratio is 30% LPG. The obtained results are validated with the results of other researchers.
Angioplasty of Anomalous Coronaries Arising from the Opposite Sinus with an Interarterial Course, is it Safe?

Background The coronary artery with an interarterial course CAIAC is the most threatening coronary anomaly, especially if it concerns the left coronary. Percutaneous coronary intervention PCI is scarcely described given its low prevalence and lack of long-term outcome data. Therefore, we assessed through this case series the feasibility and safety of PCI in this population. Methods This is an observational multicentric study including patients with CAIAC arising from the opposite sinus of Valsalva. The primary endpoints were immediate angiographic success and target lesion revascularization. Results During the period of the study, we performed 27235 PCI in six Cath labs, 26 procedures concerning abnormal coronaries including 12 with CAIAC. The median age was 57 years extremes: 43–78 with male predominance 1:11. Anomalous coronary artery was Right coronary artery RCA in eight patients, Left main LM in three patients, and left anterior descending LAD in one patient. The stenosis was located in all cases in proximal segments beyond the inter-arterial course proximal LAD, the superior genius of the RCA, or the proximal segment of mid-RCA. Five patients showed slit-like ostium and all have an angle take-off <45° on CT scan. After a median follow-up of 24 months, four subjects presented target lesion revascularization TLR, all were initially treated with either a bare-metal stent or with balloons. Conclusions PCI of patients with CAIAC is feasible and appears safe. The operator should carefully analyze the angiogram before PCI to choose the appropriate guiding catheter and should be acquainted with the different techniques for improving backup.
Smartphone Affordance: Achieving Better Business through Innovation: Cross Industry: Cross Border

This paper is a pilot study using qualitative analysis to obtain concepts related to individual perceptions of Chief Executive Officers within various industries internationally. These concepts are related to emerging technologies such as mobile devices and their usefulness within a business and personal context. Technology has played a role in human affairs including business for millennia – starting with the lighting of the first fire, the carving of ideograms on the walls of caves and inventing the first round artifact that would eventually serve as a wheel. This research has empirically documented the ways and means that mobile technologies and “Smart-phones” impact an executive’s productivity and efficiency at work by conducting a series of opened ended interviews. Our findings further corroborate the presence, role and impact of what we call “happy accidents” in terms of strategic knowledge serendipity and arbitrage (SKARSE™) as factors shaping and even driving choices made by business leaders with strategic intent and implications.
Double quantum-well tunnel junctions with high peak tunnel currents and low absorption for InP multi-junction solar cells

Lattice matched InAlGaAs tunnel junctions with a 1.18 eV bandgap have been grown for a triple-junction solar cell on InP. By including two InGaAs quantum wells in the structure, a peak tunnel current density of 113 A/cm2 was observed, 45 times greater than the baseline bulk InAlGaAs tunnel junction. The differential resistance of the quantum well device is 7.52 × 10−4 Ω cm2, a 15-fold improvement over the baseline device. The transmission loss to the bottom cell is estimated to be approximately 1.7% and a network simulation demonstrates that quantum well tunnel junctions play a key role in improving performance at high sun-concentrations.
Development of a rig and testing procedures for the experimental investigation of horizontal axis kinetic turbines

The research detailed in this thesis was focused on developing an experimental testing system to characterize the non-dimensional performance coefficients of horizontal axis kinetic turbines, including both wind turbines and tidal turbines. The testing rig was designed for use in a water tunnel with Particle Image Velocimetry (PIV) wake survey equipment to quantify the wake structures. Precision rotor torque measurement and speed control was included, along with the ability to yaw the rotor. The scale of the rotors were purposefully small, to enable rapid-prototyping techniques to be used to produce many different test rotors at low cost to furnish a large experimental dataset. The first part of this work introduces the mechanical design of the testing rig developed for measuring the output power of the scaled rotor models with consideration for the requirements imposed by the PIV wake measurements. The task was to design a rig to fit into an existing water tunnel facility with a cross sectional area of 45 by 45 cm, with a rotor support structure to minimize the flow disturbance while allowing for yawed inflow conditions. A rig with a nominal rotor diameter of 15 cm was designed and built. The size of the rotor was determined by studying the fluid similarities between wind and tidal turbines, and choosing the tip speed ratio as a scaling parameter. In order to maximize the local blade Reynolds number, and to obtain different tip speed ratios, the rig allows a rotational speed in the range of 500 to 1500 RPM with accurate rotor angular position measurements. Rotor torque measurements enable rotor mechanical power to be calculated from simulation results. Additionally, it is included in this section a description of the instrumentation for measurement and the data acquisition system.
A Novel Double U-Slot Microstrip Patch Antenna Design for Low-Profile and Broad Bandwidth Applications

A low-profile double U-slot microstrip patch antenna with a wide operating bandwidth has been developed in this article. This design produces the dual radiative resonant modes adjacent to each even at the thickness of the antenna of <inline-formula> <tex-math notation="LaTeX">$0.02 {\lambda _{0}}$ </tex-math></inline-formula>. An extremely stable radiation gain that varied from 6.2 to 6.8 dBi is achieved within the whole operating band. In addition, detailed parametric studies in this article provide antenna engineers with simple approximate rules that result in an excellent first-pass design with prescribed characteristics requiring only minimal tuning. Finally, the proposed antenna with the thickness of <inline-formula> <tex-math notation="LaTeX">$0.04 {\lambda _{0}}$ </tex-math></inline-formula> is fabricated and measured. Simulated and measured results are found in good agreement with each other. They have evidently illustrated that the bandwidth is increased by 50% compared to the traditional U-slot antenna. With the help of these simple design procedures and examples in this article, antenna designers could easily develop a low-profile broadband antenna.
Universities in the Information Age: Changing Work, Organization, and Values in Academic Science and Engineering

This article discusses a new program for collaborative study of information technology, commercialization intellectual property and transformations of education research practives in universities. Three themes define the program. First, the authors investigate the ways that information technologies shape content, organization, and delivery of faculty work. Second, they examine the interplay of issues of intellectually property, technology, commercialization, and academic research. Third, ethical issues information raise and the values they embody are explored. The research and training undertaken brings together problems usually treated by sepatate disciplines and focuses on technologies used by researchers and advanced students in various disciplines who shape and even create communications technologies. The intent is to explore these questions through research and teaching and in the process develop a new generation of scholars who are cognizant of changing patterns in the social relations of science and technology.
High Efficiency Low Cost CO2 Compression Using Supersonic Shock Wave Technology

Development and testing results from a supersonic compressor are presented. The compressor achieved record pressure ratio for a fully-supersonic stage and successfully demonstrated the technology potential. Several tasks were performed in compliance with the DOE award objectives. A high-pressure ratio compressor was retrofitted to improve rotordynamics behavior and successfully tested. An outside review panel confirmed test results and design approach. A computational fluid dynamics code used to analyze the Ramgen supersonic flowpath was extensively and successfully modified to improve use on high-performance computing platforms. A comprehensive R&D implementation plan was developed and used to lay the groundwork for a future full-scale compressor demonstration. Conceptual design for a CO2 demonstration compressor was developed and reviewed.
Assessing stakeholders' influence on social performance of infrastructure projects

Purpose – The purpose of the research presented in this paper is to develop a framework for an accurate understanding and assessment of the social performance and value creation of public infrastructure projects. Social performance evaluation is an important component of sustainable project development. In this research, the measure of social sustainability performance of projects within sustainable the development context is quantified in terms of social benefits flowing to the stakeholders as well as to the community at large.Design/methodology/approach – In this research, a framework is developed to evaluate social performance based on stakeholders' networks and their influences in the project. Adopting the social network analysis (SNA) methodology, stakeholders are firstly identified according to their roles in the project and relationships are investigated based on a structured interview process. A case study was used to demonstrate the applicability of the framework. Integrating the impact of stakeh.