Miracle-dz/UniFAR-FTUs huggingface dataset:
Integrative meta‑analysis of gene expression profiles and ENDOU as potential diagnostic biomarkers for cervical squamous cell carcinoma

Cervical carcinoma is a global public health burden. Given that it is usually asymptomatic at potentially curative stages, the development of clinically accurate tests is critical for early detection and individual risk stratification. The present study performed an integrative meta‑analysis of the transcriptomes from 10 cervical carcinoma cohorts, with the aim of identifying biomarkers that are associated with malignant transformation of cervical epithelium, and establish their clinical applicability. From among the top ranked differentially expressed genes, flap structure‑specific endonuclease 1 (FEN1) and poly (U)‑specific endoribo ‑ nuclease (ENDOU) were selected for further validation, and their clinical applicability was assessed using immunohisto‑ chemically stained microarrays comprising 110 tissue cores, using p16 and Ki67 staining as the comparator tests. The results demonstrated that FEN1 expression was significantly upregulated in 65% of tumor specimens (P=0.0001), with no detectable expression in the non‑tumor tissues. Furthermore, its expression was significantly associated with Ki67 staining in tumor samples (P<0.0001), but no association was observed with p16 expression or the presence of human papilloma virus types 16/18, patient age, tumor grade or stage. FEN1 staining demonstrated lower sensitivity than p16 (69.3 vs. 96.8%) and Ki67 (69.3 vs. 76.3%); however, the specificity was identical to p16 and higher than that of Ki67 (100 vs. 71.4%). ENDOU staining was consistent with the microarray results, demonstrating 1% positivity in tumors and 40% positivity in non‑tumor tissues. Gene set enrichment analysis of cervical tumors overexpressing FEN1 revealed its association with enhanced growth factor signaling, immune response inhibition and extracellular matrix remodeling, whereas tumors with low ENDOU expression exhibited inhibition of epithelial development and differentiation processes. Taken together, the results of the present study demonstrate the feasibility of the integrative meta‑analysis approach to identify relevant biomarkers
Relating Noncommutative SO(2,3) (cid:63) Gravity to the Lorentz-Violating Standard-Model Extension

: We consider a model of noncommutative gravity that is based on a spacetime with broken local SO(2,3) (cid:63) symmetry. We show that the torsion-free version of this model is contained within the framework of the Lorentz-violating Standard-Model Extension (SME). We analyze in detail the relation between the torsion-free, quadratic limits of the broken SO(2,3) (cid:63) model and the Standard-Model Extension. As part of the analysis, we construct the relevant geometric quantities to quadratic order in the metric perturbation around a ﬂat background.
Methods in eye research A detailed three-step protocol for live imaging of intracellular traf ﬁ c in polarized primary porcine RPE monolayers

The retinal pigment epithelium (RPE), a monolayer of cuboidal epithelial cells that sits between the photoreceptors and the choriocapillaris, is the initial site of insult in several inherited and acquired blinding diseases, including Stargardt disease, Best disease and age-related macular degeneration (AMD) (Ambati and Fowler, 2012; Bok, 2005; Rattner and Nathans, 2006). This central role for the RPE in retinal dysfunction is largely due to the many critical functions it performs to ensure healthy vision (Bok, 1993; Strauss, 2005) (Fig. 1): the RPE participates in the visual cycle by recycling retinoids to photoreceptors; RPE melanosomes absorb stray light and improve the quality of the visual image; tight junctions between RPE cells form the outer blood-retinal barrier, which maintains ion and fluid homeostasis within the retina and directs vectorial traffic of nutrients into, and metabolites out of, the retina; the RPE secretes growth factors and extracellular matrix components essential for the maintenance of photoreceptors; the RPE secretes vascular endothelial growth factor (VEGF), which is critical
Appendix to “Hierarchical community detection by recursive partitioning”

Department of Statistics, University of Virginia∗ Lihua Lei Department of Statistics, Stanford University Sharmodeep Bhattacharyya Department of Statistics, Oregon State University Koen Van den Berge † Department of Statistics, University of California, Berkeley and Department of Applied Mathematics, Computer Science and Statistics, Ghent University Purnamrita Sarkar ‡ Department of Statistics and Data Sciences, University of Texas at Austin Peter J. Bickel§ Department of Statistics, University of California, Berkeley and Elizaveta Levina¶ Department of Statistics, University of Michigan
Azole Afﬁnity of Sterol 14 (cid:1) -Demethylase (CYP51) Enzymes from Candida albicans and Homo sapiens

Candida albicans CYP51 (CaCYP51) (Erg11), full-length Homo sapiens CYP51 (HsCYP51), and truncated (cid:1) 60HsCYP51 were expressed in Escherichia coli and puriﬁed to homogeneity. CaCYP51 and both HsCYP51 enzymes bound lanosterol ( K s , 14 to 18 (cid:2) M) and catalyzed the 14 (cid:3) -demethylation of lanosterol using Homo sapiens cytochrome P450 reductase and NADPH as redox partners. Both HsCYP51 enzymes bound clotrimazole, itraconazole, and ketoconazole tightly (dissociation constants [ K d s], 42 to 131 nM) but bound ﬂuconazole ( K d , (cid:2) 30,500 nM) and voriconazole ( K d , (cid:2) 2,300 nM) weakly, whereas CaCYP51 bound all ﬁve medical azole drugs tightly ( K d s, 10 to 56 nM). Selectivity for CaCYP51 over HsCYP51 ranged from 2-fold (clotrimazole) to 540-fold (ﬂuconazole) among the medical azoles. In contrast, selectivity for CaCYP51 over (cid:1) 60HsCYP51 with agricultural azoles ranged from 3-fold (tebuconazole) to 9-fold (propiconazole). Prothioconazole bound extremely weakly to CaCYP51 and (cid:1) 60HsCYP51, producing atypical type I UV-visible difference spectra ( K d s, 6,100 and 910 nM, respectively), indicating that binding was not accomplished through direct coordination with the heme ferric ion. Prothioconazole-desthio (the intracellular
Gravitational environments, flows and holographic fluids

The thesis is focused on the study of various gravitational environments in 4 dimensions: gravitational instantons and black holes both in general relativity and in supergravity. In general relativity, the search of new exact solutions is a challenging task. A peculiar simplifying assumption is the one of self-duality of the Riemann tensor. This condition provides a class of gravitational instantons. The temporal evolution of the instantons is described by a geometric flow. This connection has been analyzed in full details. In particular, the role of the Ricci tensor within the geometric flow bas been unraveled. It is a challenging question to exhibit new stationary axysymmetric black holes in AdS space. This question arises in the framework of holographic fluid dynamics. Rotating systems in the bulk correspond to fluids with non-trivial vorticity in the boundary. Regularity of the solution at the horizon implies that the boundary fluid has the form of a perfect-fluid. The holographic correspondence is usually done through a perturbative expansion. Necessary conditions have been found such that the expansion can be resummed and exact solutions of relativity can be generated. A microscopic counting of the entropy of black holes in AdS is not available yet. In the case of N=2 supergravity in four dimensions, a relation between rotating non-BPS extremal asymptotically flat black holes and BPS rotating asymptotically AdS black holes has been discovered. This procedure indicates that, for extremal black holes, a supersymmetric conformal field theory dual can be found, thus gaining insights on the role of gaugings in the microscopic counting.
superconformal Calogero models

: We continue the research initiated in hep-th/0607215 and apply our method of conformal automorphisms to generate various N =4 superconformal quantum many-body systems on the real line from a set of decoupled particles extended by fermionic degrees of freedom. The su (1 , 1 | 2) invariant models are governed by two scalar potentials obeying a system of nonlinear partial diﬀerential equations which generalizes the Witten-Dijkgraaf-Verlinde-Verlinde equations. As an application, the N =4 superconformal extension of the three-particle ( A -type) Calogero model generates a unique G 2 -type Hamiltonian featuring three-body interactions. We fully analyze the N =4 superconformal three- and four-particle models based on the root systems of A 1 ⊕ G 2 and F 4 , respectively. Beyond Wyllard’s solutions we ﬁnd a list of new models, whose translational non-invariance of the center-of-mass motion fails to decouple and extends even to the relative particle motion.
Re ning Black men’s depression measurement using participatory approaches: a concept mapping study

Leslie B. Adams (  LADAMS36@JHU.EDU ) Johns Hopkins University Samuel Baxter Clemson University Alexandra Lightfoot University of North Carolina at Chapel Hill Nisha Gottfredson University of North Carolina at Chapel Hill Carol Golin University of North Carolina at Chapel Hill Leron Jackson University of North Carolina at Chapel Hill James Tabron University of North Carolina at Chapel Hill Giselle Corbie-Smith University of North Carolina at Chapel Hill Wizdom Powell University of Connecticut Health Center
COPD_A_276082 2901..2912

1Co-Construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P.R. China, Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; 2Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; 3The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; 4Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, People’s Republic of China; 5The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China; 6The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China; 7Haici Hospital of Qingdao, Qingdao, People’s Republic of China; 8Zhengzhou People’s Hospital, Zhengzhou, People’s Republic of China; 9Shanxi Hospital of Integrated Traditional and Western Medicine, Taiyuan, People’s Republic of China; 10Nanyang City Center Hospital, Nanyang, People’s Republic of China
CMAR_A_330308 7289..7297

1Department of Nuclear Medicine, Soonchunhyang University College of Medicine, Seoul, Korea; 2Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; 3Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; 4Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, Korea Purpose: The clinical value of F-fluorodeoxyglucose positron emission tomography/ computed tomography (FDG PET/CT) in intravascular large B-cell lymphoma (IVLBCL) is unknown. This study investigated the association between PET/CT features and prognosis in IVLBCL patients. Patients and Methods: Subjects were 30 newly diagnosed Asian variant IVLBCL patients at a single institution. Baseline PET/CT was analyzed for the distribution and intensity of FDG lesions, and PET/CT pattern groups were compared for the outcome. Results: Eight patients had hypermetabolic lymph node (LN) lesions (Nodal group). The remaining 22 patients with extranodal (EN) involvement were categorized into Deauville score 3–4 (EN/DS3-4; n = 14) and DS5 groups (EN/DS5; n = 8). First-line therapy resulted in a complete or partial response in 75.0%, 64.3%, and 100% of the respective groups. Treatment-related deaths occurred in one nodal group and three EN/DS3-4 group cases, but none among the EN/DS5 group. During 56 months of follow-up, disease progression or relapse occurred in five, four, and one case of respective groups. Cancer-related death occurred more frequently in the Nodal (n = 6) and EN/DS3-4 groups (n = 7) than the EN/ DS5 group (n = 1; P = 0.041). Nodal and EN/DS3-4 groups had worse 5-year event-free survival (EFS; 25.0% and 49.0%, respectively, P = 0.010 and 0.076) and overall survival (OS; 33.3% and 48.2%, P = 0.010 and 0.068) compared to the EN/DS5 group (87.5% EFS and 87.5% OS). Conclusion: In patients with Asian variant IVLBCL, the distribution and intensity of FDG uptake lesions on PET/CT can be useful for predicting treatment outcomes and survival.
How do we form trust online?

Online trust has been cited as one of the most important reasons as to why someone choose to participate in e-commerce. The main research goal in this thesis is to explore the concept of online trust in e-commerce, how it is formed and by extension how it can be designed for. This thesis considers the research question “How can e-commerce websites be designed to be trust-inducing? ”. First a literature study on the background of trust research was performed and the underlying factors of trust and the design elements that affect the formation of trust mapped out. Then popular Swedish ecommerce websites were investigated and design patterns were mapped out based on those websites. Based on previous research and the experience gained from these websites, 13 guidelines with focus on trust-inducing e-commerce design were created. To test the usefulness of the guidelines, analyses of websites using the guidelines were performed, as well as expert evaluations of websites by six of the authors peers. Overall this study found that the design of the websites that were investigated was lacking in customer service, third-party certifications and social-cue design in general. The thesis contributes to better website trust design by putting forth guidelines. The knowledge gained from the analyses of websites is a contribution in itself since it provides an understanding of how well ecommerce websites design for trust and which the most common design issues are.
DDDT_A_330154 4157..4166

The Cancer Center of the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong Province, 519000, People’s Republic of China; Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, 519000, People’s Republic of China; Department of Nuclear Medicine, Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, 519000, People’s Republic of China; Department of Pathology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong Province, 519001, People’s Republic of China; Department of Pharmacy, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, 519000, People’s Republic of China; Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, People’s Republic of China; Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, 12144, USA; Department of Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, 519000, People’s Republic of China
FPGAs and the Cloud – An Endless Tale of Virtualization, Elasticity and Efﬁciency

—Field Programmable Gate Arrays (FPGAs) provide a promising opportunity to improve performance, security and energy efﬁciency of computing architectures, which are essential in modern data centers. Especially the background acceleration of complex and computationally intensive tasks is an important ﬁeld of application. The ﬂexible use of reconﬁgurable devices within a cloud context requires abstraction from the actual hardware through virtualization to offer these resources to service providers. In this paper, we present our Reconﬁgurable Common Computing Frame (RC2F) approach – inspired by system virtual machines – for the profound virtualization of reconﬁgurable hardware in cloud services. Using partial reconﬁguration, our framework abstracts a single physical FPGA into multiple independent virtual FPGAs (vFPGAs). A user can request vFPGAs of different size for optimal resource utilization and energy efﬁciency of the whole cloud system. To enable such ﬂexibility, we create homogeneous partitions on top of an inhomogeneous FPGA fabric abstracting from physical locations and static areas. The RC2F SEC extension combines this virtualization with a security system to allow for processing of sensitive data. On the host side our Reconﬁgurable Common Cloud Computing Environment (RC3E) offers different service models and manages the allocation of the dynamic vFPGAs. We demonstrate the possibilities and the resource trade-off of our approach in a basic scenario. Moreover, we present future perspectives for the use of FPGAs in cloud-based environments.
An analytical framework for musical live coding systems based on gestural interactions in performance practices

Gestural interaction in live coding performance is still in its infancy, albeit the long tradition in music performance studies. Computational challenges in musical live coding have been motivating the research community towards the development of novel programming languages and interfaces. On the other hand, given the maturity of many music systems there is an increasing demand for theory building on live coding systems and practices. Here, we present an observational study from videos of live performances available online and we introduce an analytical framework for live coding music systems. We begin by examining how performance practices differ on potentially equivalent systems. On the spotlight of the framework is the viewpoint of gestural interactions under the prism of music psychology and perception. We examined several systems on three main processes: (i) interface design, (ii) gestural mapping and (iii) user's interaction. These processes are presented as an orthogonal three-dimensional framework, so to facilitate visualizations and readers' understanding. Preliminary assessments of the systems in question agree with ground truth knowledge of the computational classification of the systems. Furthermore, we analyze a few notable systems that are stretching the boundaries of our dimensional framework, indicating that more dimensions may be required. Finally, we discuss the analytical framework in relation to a higher-level description of live coding music performance and we discuss future studies that may be conducted to assess the validity of this approach.
Nonsystematic backtracking search

Many practical problems in Artificial Intelligence have search trees that are too large to search exhaustively in the amount of time allowed. Chronological backtracking can be applied to these problems, but it is unlikely to find a solution in the explored fraction of the space because of the order in which it examines nodes. A nonsystematic technique known as iterative sampling alleviates the problem by examining fringe nodes in a random order. Although nonsystematic techniques do not suffer from the problem of exploring nodes in a bad order, they do reconsider nodes they have already ruled out, a problem that is serious when the density of solutions is low. Unfortunately, for many practical problems, the order of examining nodes matters and the density of solutions is low. Consequently, neither chronological backtracking nor iterative sampling has good average case performance. We present a new search algorithm called bounded backtrack search that combines the merits of backtracking and iterative sampling. The algorithm backtracks chronologically until reaching a backtrack bound, whereupon it immediately backtracks to the root and restarts on a new random path. We show that the new algorithm does not suffer from the problems of the alternatives, and we derive theoretical conditions that guarantee better average case performance. Our analysis also shows that chronological backtracking does not use successor ordering heuristics effectively. The accuracy of the heuristics for early decisions is critical to the algorithm's efficiency, whereas the accuracy is relatively unimportant deep in the tree because the alternatives are considered quickly. Unfortunately, heuristics are typically least reliable for the early decisions--when they are most important. We present a second new algorithm called limited discrepancy search that examines nodes in increasing order of "discrepancies," or points of disagreement with a problem's heuristics. We show that the algorithm has exceptional average case performance when the heuristics are accurate and reasonable performance when the heuristics are bad. We present experimental results in job shop scheduling to show that the theoretical conditions and the expected performance hold for real problems.
CARBOHYDRATE AND CAFFEINE MOUTH RINSE AFTER 45-MIN OF AN INTERMITTENT SHUTTLE RUN TEST DID NOT ENHANCE FOOTBALL PERFORMANCE IN COLLEGIATE PLAYERS

Introduction: Carbohydrate (CHO) mouth rinse improves exercise lasting ≤ 1 h, whereas caffeine (CAF) mouth rinse increases the performance of repeated bouts of short duration, high-intensity cycling. Limited research is currently available regarding the effects of a combined CHO and CAF mouth rinse on repeated sprint and skill patterns in team sports. This study examined the effect of a CHO and CAF mouth rinse on sprint running and football skill performance. Methods: Twenty-four male collegiate football and futsal players participated in a counterbalanced, double-blinded study where they completed 45 min of the Loughborough Intermittent Shuttle Test (LIST) on four occasions separated by at least 1 wk. Participants rinsed and expectorated 25 ml of 6.4% maltodextrin (CHO), 1.2% CAF, 6.4% maltodextrin combined with 1.2% CAF (CHO+CAF), or placebo for 10 s every 5 min after completing the LIST. Then, they performed repeated sprint ability, the Loughborough Soccer Passing Test, and Loughborough Soccer Shooting Test. Results: There was no significant improvement in the average (p=0.759) or fastest sprint times (p=0.916). There were no significant differences in the passing time (p=0.756), shooting time (p=0.579), and points scored per shot (p=0.500). There were also no significant differences in heart rate and rating of perceived exertion between the solutions. Conclusion: The CHO and/or CAF mouth rinse did not improve football performance including sprint running, passing, shooting, and scoring after 45 -min of intermittent exercise in collegiate male athletes. The findings of the current study are unique, in that this is the first study to investigate the effects of a mouth rinse on football skill. We found that mouth rinsing with CHO, CAF, or a combined solution (CHO+CAF) after 45 min of an intermittent shuttle run test did not improve football performance in collegiate football and futsal players. At this time, more work is needed to fully examine the effect of CHO and CAF mouth rinsing on football performance. However, mouth rinse is still a useful strategy to consider for athletes who are sensitive to the volume of fluid in their stomach or those who suffer from gastrointestinal discomfort with food/fluid ingestion during exercise. In addition, athletes who might not have adequate time for a pre-exercise meal or require a boost at a key moment during competitions (e.g. penalty kicks, extra time) may benefit from the use of a mouth rinse.
Edinburgh Explorer Knowledge, Causality and Temporal Representation

In this paper, a formal semantic account of the simple past tense in text is offered. The contributions to the interpretation of text made by the text's syntactic structure, semantic content, aspectual classification, world knowledge of the causal relations between events, and Gricean pragmatic maxims are all represented within a single logical framework. This feature of the theory gives rise to solutions to several puzzles concerning the relation between the descriptive order of events in text and their temporal relations in interpretation.