Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis on design parameters of plasma limiter for protecting against high power electromagnetic pulse

The coupling path of high power electromagnetic (HPEM) to electronic devices is divided into following two ways, one is the Front-door coupling and the other is the Back-door coupling [1]. The former is flow in an intended path such as antennas or sensors and the latter is inflow through an unintended path such as holes or cables. As HPEM pulse has higher power and it causes larger damage to electronic devices, it is necessary to research the protection method of RF systems affected by HPEM pulse in the front-end coupling path case. In this paper, the design parameters of the plasma limiter are analyzed for optimal design to protect against HPEM pulse. There are several limiters to reduce high power microwave power such as solid-state limiter and ferrite materials, etc [2]. but the plasma limiter uses the discharge electrode in waveguide [3]. Therefore it is suitable to protect HPEM pulse before it reaches the RF front-end system. Despite the ability to defend highpower microwave, the plasma limiter has some problem such as its expensive cost and complicated process than semiconductor limiters, so the research for optimal design is essential. Using our analysis on design parameters of the plasma limiter, it is expected that to improve a protecting performance and to figure out the optimal design.
Npas4 deficiency interacts with adolescent stress to disrupt prefrontal GABAergic maturation and adult cognitive flexibility

Healthy cognitive and emotional functioning relies on a balance between excitatory and inhibitory neurotransmission in the prefrontal cortex (PFC). This balance is largely established during early postnatal and adolescent developmental periods by maturation of the γ‐aminobutyric acid (GABA) system, including increased density of parvalbumin (PV) cells and perineuronal nets (PNNs). Genetic and/or environmental factors during adolescence can disrupt GABAergic maturation and lead to behavioral dysfunction in adulthood. The present study examined the interaction between chronic mild stress during adolescence and genetic deficiency of neuronal Per‐Arnt‐Sim domain 4 (Npas4), a brain‐specific transcription factor that regulates inhibitory neurotransmission and that contributes to adolescent prefrontal GABAergic maturation. Male Npas4 wild‐type (WT) and heterozygous (HET) mice were exposed to adolescent chronic stress and tested in adulthood for cognitive function using the attention set shifting task. When Npas4 deficiency was combined with adolescent stress, mice displayed impaired cognitive flexibility as observed by poor performance on the extra‐dimensional set shift task. At the cellular level, adolescent stress increased the percentage of PV cells surrounded by PNNs in the PFC of adult WT animals, an effect that was not observed in HET mice. Additionally, Npas4 deficiency and/or adolescent stress dysregulated expression of certain GABAergic system markers. These results suggest that Npas4 mediates susceptibility to adolescent stress and subsequent cognitive functioning and inhibitory tone in adulthood. This shows a novel gene by environment interaction related to resilience vs vulnerability to stress, with implications for adolescent onset disorders like schizophrenia.
CRMP-1 enhances EVL-mediated actin elongation to build lamellipodia and the actin cortex

Cells can control actin polymerization by nucleating new filaments or elongating existing ones. We recently identified CRMP-1 as a factor that stimulates the formation of Listeria monocytogenes actin comet tails, thereby implicating it in actin assembly. We now show that CRMP-1 is a major contributor to actin assembly in epithelial cells, where it works with the Ena/VASP family member EVL to assemble the actin cytoskeleton in the apical cortex and in protruding lamellipodia. CRMP-1 and EVL bind to one another and together accelerate actin filament barbed-end elongation. CRMP-1 also stimulates actin assembly in the presence of VASP and Mena in vitro, but CRMP-1–dependent actin assembly in MDCK cells is EVL specific. Our results identify CRMP-1 as a novel regulator of actin filament elongation and reveal a surprisingly important role for CRMP-1, EVL, and actin polymerization in maintaining the structural integrity of epithelial sheets.
A Modified Electrostatic Adsorption Apparatus for Latent Fingerprint Development on Unfired Cartridge Cases

Visualization of latent fingerprints on metallic surfaces by the method of applying electrostatic charging and adsorption is considered as a promising chemical‐free method, which has the merit of nondestruction, and is considered to be effective for some difficult situations such as aged fingerprint deposits or those exposed to environmental extremes. In fact, a portable electrostatic generator can be easily accessible in a local forensic technology laboratory, which is already widely used in the visualization of footwear impressions. In this study, a modified version of this electrostatic apparatus is proposed for latent fingerprint development and has shown great potential in visualizing fingerprints on metallic surfaces such as cartridge cases. Results indicate that this experimental arrangement can successfully develop aged latent fingerprints on metal surfaces, and we demonstrate its effectiveness compared with existing conventional fingerprint recovery methods.
Documentação de atividades de aprendizagem com uso de tecnologias

Learning Design (ou Design da Aprendizagem) e uma area de pesquisa que tem por objetivo tornar mais explicito o processo de concepcao de praticas educativas com o uso de tecnologias, a partir de diretrizes para documentar, modelar e compartilhar estas praticas. Este capitulo tem como objetivo apresentar a area de Learning Design, focando especialmente na documentacao de atividades de aprendizagem por meio de artefatos de mediacao, a fim de impulsionar o processo de planejamento e compartilhamento de atividades de aprendizagem. Entende-se que a documentacao de atividades de aprendizagem ira facilitar trocas entre os professores e, portanto, vai ao encontro de estudos atuais na area de praticas educacionais abertas.
Proteome Data Improves Protein Function Prediction in the Interactome of Helicobacter pylori *

Helicobacter pylori is a common pathogen that is estimated to infect half of the human population, causing several diseases such as duodenal ulcer. Despite one of the first pathogens to be sequenced, its proteome remains poorly characterized as about one-third of its proteins have no functional annotation. Here, we integrate and analyze known protein interactions with proteomic and genomic data from different sources. We find that proteins with similar abundances tend to interact. Such an observation is accompanied by a trend of interactions to appear between proteins of similar functions, although some show marked cross-talk to others. Protein function prediction with protein interactions is significantly improved when interactions from other bacteria are included in our network, allowing us to obtain putative functions of more than 300 poorly or previously uncharacterized proteins. Proteins that are critical for the topological controllability of the underlying network are significantly enriched with genes that are up-regulated in the spiral compared with the coccoid form of H. pylori. Determining their evolutionary conservation, we present evidence that 80 protein complexes are identical in composition with their counterparts in Escherichia coli, while 85 are partially conserved and 120 complexes are completely absent. Furthermore, we determine network clusters that coincide with related functions, gene essentiality, genetic context, cellular localization, and gene expression in different cellular states.
On the Power Allocation and Constellation Selection in Downlink NOMA

In non-orthogonal multiple access (NOMA), signals of different users are independently encoded and modulated, then superposed in the power domain before transmission. The choice of a suitable combination of power allocation factor (PAF) and transmit constellations is hence critical to enhance the system performance. The aim of this work is to develop a tool for adaptively selecting a suitable PAF and transmit constellations for an enhanced system data rate, given some individual user bit error rate (BER) constraints that need to be jointly considered. For this purpose, analytical bit error probability (BEP) expressions are derived and evaluated. This is the first attempt to analytically evaluate the BER in NOMA systems. The expressions are evaluated in order to propose the best combination of MCS and PAF. The trade-offs involved in selecting a certain combination of transmit constellations and PAF are also investigated. Moreover, numerical evaluations prove that the attainable BEP at the near user is affected by that of the far user. Look-up tables of suitable combinations of PAF and transmit constellations are derived using the BEP expressions, with a focus on enhancing the system data rate for some given BER constraints at both users.
An online fault detection model and strategies based on SVM-grid in clouds

Online fault detection is one of the key technologies to improve the performance of cloud systems. The current data of cloud systems is to be monitored, collected and used to reflect their state. Its use can potentially help cloud managers take some timely measures before fault occurrence in clouds. Because of the complex structure and dynamic change characteristics of the clouds, existing fault detection methods suffer from the problems of low efficiency and low accuracy. In order to solve them, this work proposes an online detection model based on asystematic parameter-search method called SVM U+002D Grid, whose construction is based on a support vector machine U+0028 SVM U+0029. SVM U+002D Grid is used to optimize parameters in SVM. Proper attributes of a cloud system U+02BC s running data are selected by using Pearson correlation and principal component analysis for the model. Strategies of predicting cloud faults and updating fault sample databases are proposed to optimize the model and improve its performance. In comparison with some representative existing methods, the proposed model can achieve more efficient and accurate fault detection for cloud systems.
Molecular Cloning and Functional Characterization of the Upstream Promoter Region of the Human p 73 Gene

The p73 gene encodes a protein that shares structural and functional homologies with the p53 tumor suppressor protein. To investigate the mechanism of transcriptional regulation of the p73 gene, we isolated a genomic DNA fragment spanning the 5' upstream region of the human p73 gene and characterized the promoter region. Unlike the p53 gene promoter, the human p73 gene promoter contained a putative TATAbox, and did not exhibit any extended homology to the p53 gene. Two CpG islands were located in the 5' upstream region. Transient transfection assays using progressive truncations of the p73 promoter showed that deletion from -119 to +19 relative to exon 1 resulted in a 13to 20-fold reduction in the p73 promoter activity, suggesting that the elements for basal promoter activity exist in this region, where putative Spl, AP-2 and Egr-1, 2, 3 sites are located and CpG dinucleotides are especially concentrated.
Teaching tools to engage Anishinaabek First Nations women in cervical cancer screening: Report of an educational workshop

Objective: To explore educational strategies for engaging First Nations women in Canada to attend cervical cancer screening. Design: Within a participatory action research framework, semi-structured interviews with health-care providers in First Nations communities revealed that education about the value of screening is perceived as being a key factor to promote cervical cancer screening. Setting: To obtain feedback from workshop informants, a 1-day educational workshop was held to identify appropriate educational intervention strategies, which would be applied in a forthcoming randomised controlled cervical screening trial. Methods: Common discussion and discussion groups, which were facilitated by a First Nations workshop moderator and a note taker. Results: This workshop helped to strengthen the ethical space dialogue with the First Nations communities with whom the study team had established research partnerships. The workshop atmosphere was relaxed and the invited informants decided that an educational health promotion event for community women needed to be held prior to inviting them to the cervical screening trial. Such an event would provide an opportunity to communicate the importance of attending regular cervical screening allowing women to make informed decisions about screening participation. Complementary promotional items, including an eye-catching pamphlet and storytelling, were also suggested. Conclusion: The key messages from the events and promotional items can help to de-stigmatise women who develop a type of cancer that is caused by a sexually transmitted virus that affects both men and women. Developing and implementing positive health education that respectfully depicts female bodies, sexuality and health behaviours through a First Nations lens is strongly warranted.
Comparative analysis between direction of arrival algorithms

In today's world Smart antenna systems have emerged as one of the most prominent way for an efficient wireless system. According to authors, in this research a comparative study has been conducted among 3 direction of arrival algorithms namely Capon, MUSIC and Pisarenko. After application of Matlab simulations on the mentioned algorithms using user capacity and interference as benchmark parameters compared by their pseudo spectrum, Pisarenko estimation has been found to cover most of the users with comparatively low interference than the former two.
Environmental enrichment facilitates cocaine‐cue extinction, deters reacquisition of cocaine self‐administration and alters AMPAR GluA1 expression and phosphorylation

This study investigated the combination of environmental enrichment (EE) with cocaine‐cue extinction training on reacquisition of cocaine self‐administration. Rats were trained under a second‐order schedule for which responses were maintained by cocaine injections and cocaine‐paired stimuli. During three weekly extinction sessions, saline was substituted for cocaine but cocaine‐paired stimuli were presented. Rats received 4‐h periods of EE at strategic time points during extinction training, or received NoEE. Additional control rats received EE or NoEE without extinction training. One week later, reacquisition of cocaine self‐administration was evaluated for 15 sessions, and then GluA1 expression, a cellular substrate for learning and memory, was measured in selected brain regions. EE provided both 24 h before and immediately after extinction training facilitated extinction learning and deterred reacquisition of cocaine self‐administration for up to 13 sessions. Each intervention by itself (EE alone or extinction alone) was ineffective, as was EE scheduled at individual time points (EE 4 h or 24 h before, or EE immediately or 6 h after, each extinction training session). Under these conditions, rats rapidly reacquired baseline rates of cocaine self‐administration. Cocaine self‐administration alone decreased total GluA1 and/or pSer845GluA1 expression in basolateral amygdala and nucleus accumbens. Extinction training, with or without EE, opposed these changes and also increased total GluA1 in ventromedial prefrontal cortex and dorsal hippocampus. EE alone increased pSer845GluA1 and EE combined with extinction training decreased pSer845GluA1 in ventromedial prefrontal cortex. EE might be a useful adjunct to extinction therapy by enabling neuroplasticity that deters relapse to cocaine self‐administration.
To Investigate the Effects of Air Pollution (PM10 and SO2) on the Respiratory Diseases Asthma and Chronic Obstructive Pulmonary Disease.

OBJECTIVES Effects of air pollution parameters of sulfur dioxide (SO2) and particulate matter (PM10) values on the respiratory system were investigated. MATERIAL AND METHODS Data of SO2 and PM10 were obtained daily for air pollution and classified into two groups: Group I (2006-2007), coal burning years and Group II (2008-2009), natural gas+ coal burning. Groups I and II were divided into two subgroups according to the months of combustion as combustible (November-April) and noncombustible (May-October). The number of patients with asthma and chronic obstructive pulmonary disorder (COPD) was recorded between 2006 and 2009. RESULTS There was no statistically significant difference between Groups I and II for PM10 and SO2 (p>0.05). Within the years, the values of SO2 and PM10 were statistically different between the groups defined by month (p<0.01). The number of patients in the combustible and noncombustible subgroups were found to be different for every 4 years, and the numbers of patients with COPD or asthma were not changed through the years. There was a strong correlation between PM10 and COPD (r=0.59, p<0.01) and a weak correlation between PM10 and asthma (r=0.25, p>0.05). A correlation was found between SO2 and COPD (p<0.01) but not between SO2 and asthma (p>0.05). The number of visits for COPD and asthma was statistically different between combustible and noncombustible subgroups (X2:58.61, p=0.000; X2:34.55, p=0.000, respectively). The r2 values for SO2 and PM10 for COPD patients were 17% and 24%, respectively, in contrast to 8% and 5%, respectivley for asthma patients. CONCLUSION Air pollution is known to increase respiratory disease occurrences. With decrease in the usage of solid fuel, air pollution could be reduced and may be effective in preventing respiratory diseases.
Global Impact of 2017 American College of Cardiology/American Heart Association Hypertension Guidelines: A Perspective From China.

A shocking change in the 2017 American College of Cardiology/American Heart Association hypertension guidelines is the shift in the definition of hypertension from 140/90 mm Hg to 130/80 mm Hg for systolic/diastolic blood pressure.1 It was indeed a major change since the definition of hypertension was changed from 160/90 mm Hg to 140/90 mm Hg in the fifth report of the Joint National Committee published in 1993.2 History is often repeated and similarities sometimes emerge. Very similar to the change in 1993,2 the current change in the 2017 guidelines was mainly based on epidemiological evidence but not randomized controlled clinical trials.1 There is strong and consistent evidence that lower blood pressure is associated with lower cardiovascular risk, even if not to the point of the lower the better. There is little or insufficient evidence on the outcome benefit of antihypertensive therapy from adequately powered, placebo-controlled clinical trials even in the range of systolic blood pressure from 140 to 159 mm Hg, needless to say for 130 to 139 mm Hg. However, the current change,1 like the previous one,2 is probably not only conceptually encouraging, but also eventually beneficial for cardiovascular prevention. …
Effect of Patient Navigation and Financial Incentives on Smoking Cessation Among Primary Care Patients at an Urban Safety-Net Hospital: A Randomized Clinical Trial

Importance While the proportion of adults who smoke cigarettes has declined substantially in the past decade, socioeconomic disparities in cigarette smoking remain. Few interventions have targeted low socioeconomic status (SES) and minority smokers in primary care settings. Objective To evaluate a multicomponent intervention to promote smoking cessation among low-SES and minority smokers. Design, Setting, and Participants For this prospective, unblinded, randomized clinical trial conducted between May 1, 2015, and September 4, 2017, adults 18 years and older who spoke English, smoked 10 or more cigarettes per day in the past week, were contemplating or preparing to quit smoking, and had a primary care clinician were recruited from general internal medicine and family medicine practices at 1 large safety-net hospital in Boston, Massachusetts. Interventions Patients were randomized to a control group that received an enhancement of usual care (n = 175 participants) or to an intervention group that received up to 4 hours of patient navigation delivered over 6 months in addition to usual care, as well as financial incentives for biochemically confirmed smoking cessation at 6 and 12 months following enrollment (n = 177 participants). Main Outcomes and Measures The primary outcome determined a priori was biochemically confirmed smoking cessation at 12 months. Results Among 352 patients who were randomized (mean [SD] age, 50.0 [11.0] years; 191 women [54.3%]; 197 participants who identified as non–Hispanic black [56.0%]; 40 participants who identified as Hispanic of any race [11.4%]), all were included in the intention-to-treat analysis. At 12 months following enrollment, 21 participants [11.9%] in the navigation and incentives group, compared with 4 participants [2.3%] in the control group, had quit smoking (odds ratio, 5.8; 95% CI, 1.9-17.1; number needed to treat, 10.4; P < .001). In prespecified subgroup analyses, the intervention was particularly beneficial for older participants (19 [19.8%] vs 1 [1.0%]; P < .001), women (17 [16.8%] vs 2 [2.2%]; P < .001), participants with household yearly income of $20 000 or less (15 [15.5%] vs 3 [3.1%]; P = .003), and nonwhite participants (21 [15.2%] vs 4 [3.0%]; P < .001). Conclusions and Relevance In this study of adult daily smokers at 1 large urban safety-net hospital, patient navigation and financial incentives for smoking cessation significantly increased the rates of smoking cessation. Trial Registration clinicaltrials.gov Identifier: NCT02351609
Removal of Listeria monocytogenes dual-species biofilms using combined enzyme-benzalkonium chloride treatments

Abstract The effects of pronase (PRN), cellulase (CEL) or DNaseI alone or combined with benzalkonium chloride (BAC) against Listeria monocytogenes-carrying biofilms were assayed. The best removal activity against L. monocytogenes–Escherichia coli biofilms was obtained using DNaseI followed by PRN and CEL. Subsequently, a modified logistic model was used to quantify the combined effects of PRN or DNaseI with BAC. A better BAC performance after PRN compared to DNaseI eradicating L. monocytogenes was observed. In E. coli the effects were the opposite. Finally, effects of DNaseI and DNaseI–BAC treatments were compared against two different L. monocytogenes-carrying biofilms. DNaseI–BAC was more effective against L. monocytogenes when co-cultured with E. coli. Nonetheless, comparing the removal effects after BAC addition, these were higher in mixed-biofilms with Pseudomonas fluorescens. However, a high number of released viable cells was observed after combined treatments. These results open new perspectives of enzymes as an anti-biofilm strategy for environmental pathogen control.