Miracle-dz/UniFAR-FTUs huggingface dataset:
The Flat Plate Boundary Layer Equation under Blasius Restrictions with a Unique Solution

Even though Blasius’s flat plate boundary layer equation is considered an outstanding application of the boundary layer theory, it presents a series of inconsistencies both in its deduction and solution. This work reexamines, in detail, the fundamentals of the classical equation and the method to solve it to build correlations associated with the proposed new flat plate boundary equation and its solution. It deals with being well aware of avoiding or excluding the existing mathematical and erroneous physical considerations involved to improve the design, analysis, and solution of many practical problems in the fields of Fluid Mechanics and other scientific and technical areas. The new proposed flat plate boundary layer equation has a unique solution and satisfies Prandtl’s boundary layer concept; its inherent flow is sensitive to the transition phenomenon. In this sense, depending on the Reynolds number, it can generate perturbations that will justify the origin of the Tollmien–Schlitching waves.
Learning Place Control: Vietnamese EFL Students’ Appreciation and Trust

Learners in the contemporary digital world tend to move from space to space during their learning process. However, transforming such spaces to effective learning places is not simple. This study aims to investigate Vietnamese EFL students’ appreciation for various learning spaces and their willingness in turning those spaces into places for learning purposes. The factors associated with this process are also explored. Employing a short questionnaire distributed to 226 undergraduate students and several follow up individual interviews, the study shows that most students travel across some spaces in their daily learning activities, but they do not try to control those spaces. They only appreciate their teacher-created and self-created solo learning spaces and accept these spaces as their learning places. They also agree that these are the spaces where they can best control their learning. These findings present a complex picture of students’ exercise of taking control in their learning. It appears that the initiation of their learning must start with trust and convenience in a learning space. The attempt to control a learning space does not start with careful considerations as often seen in autonomous learners. This emphasises the role of trust in nurturing and shaping learners’ capacity of space control for learning purposes.
On the applicability of Eshelby’s inclusion analogy to a reinforced hole

Abstract A plate containing a circular hole, and reinforced by a patch may as a first approximation, be analysed by treating the reinforced structure as a plate containing an inclusion. This leads to a state of uniform stress in the inclusion. In this paper, an exact solution is obtained using a layered-plate theory where a general remote biaxial loading is split into a combination of hydrostatic tension and pure-shear. The focus is on the pure-shear component where it is found that the stress in the reinforcement over the hole is not uniform, contrary to the expectation from the two-dimensional inclusion analogy.
Network Pharmacology Deciphers the Action of Bioactive Polypeptide in Attenuating Inflammatory Osteolysis via the Suppression of Oxidative Stress and Restoration of Bone Remodeling Balance

Oxidative stress involves enormously in the development of chronic inflammatory bone disease, wherein the overproduction of reactive oxygen species (ROS) negatively impacts the bone remodeling via promoting osteoclastogenesis and inhibiting osteogenesis. Lacking effective therapies highlights the importance of finding novel treatments. Our previous study screened a novel bioactive peptide D7 and demonstrated it could enhance the cell behaviors and protect bone marrow mesenchymal stem cells (BMSCs). Since BMSCs are progenitor cells of osteoblast (OB), we therefore ask whether D7 could also protect against the progress of inflammatory osteolysis. To validate our hypothesis and elucidate the underlying mechanisms, we first performed network pharmacology-based analysis according to the molecule structure of D7, and then followed by pharmacological evaluation on D7 by in vitro lipopolysaccharide(LPS)-induced models. The result from network pharmacology identified 20 candidate targets of D7 for inflammatory osteolysis intervention. The further analysis of Gene Ontology (GO)/KEGG pathway enrichment suggested the therapeutic effect of D7 may primarily affect osteoclast (OC) differentiation and function during the inflammatory osteolysis. Through validating the real effects of D7 on OC and OB as postulated, results demonstrated suppressive effects of D7 on LPS-stimulated OC differentiation and resorption, via the inhibition on OC marker genes. Contrarily, by improving the expression of OB marker genes, D7 displayed promotive effects on OB differentiation and alleviated LPS-induced osteogenic damage. Further mechanism study revealed that D7 could reduce LPS-induced ROS formation and strengthen antioxidants expressions in both OC and OB precursors, ameliorating LPS-triggered redox imbalance in bone remodeling. Taken together, our findings unveiled therapeutic effects of D7 against LPS-induced inflammatory osteolysis through the suppression of oxidative stress and the restoration of the bone remodeling process, providing a new therapeutic candidate for chronic inflammatory bone diseases.
Emotional Exhaustion and Turnover Intentions among Counselors in Rural Substance Use Disorder Treatment Programs

Abstract Counselor turnover is a serious problem for substance use disorder (SUD) treatment programs, especially in rural areas. This study examined the relationship between workload, workplace environment, and emotional exhaustion on turnover intentions among SUD treatment counselors in rural Pennsylvania. An online, anonymous survey was administered to rural SUD treatment counselors in Pennsylvania between October and December 2020. Completed surveys from 206 counselors were used for analysis. Variables included multi-dimensional measures of emotional exhaustion, intention to quit, workload, and workplace environment. Results showed age, perceptions of distributive justice, and management communication to be inversely related to emotional exhaustion and intention to quit. A subsequent analysis showed that the direct effects of these variables on intention to quit were reduced with the inclusion of emotional exhaustion in modeling, suggesting a potential mediation effect. Findings indicated that higher levels of emotional exhaustion were directly related to a greater intention to quit. A statistically significant indirect relationship was also found for distributive justice on intention to quit through emotional exhaustion, indicating a significant mediating effect. While counseling is a stressful occupation with high potential for burnout, these results show that organizations can adopt practices that help lower emotional exhaustion and turnover intentions for their counselors which could improve retention in the SUD treatment field. This is especially important for rural areas, where there is a high demand for SUD services and not enough treatment workers to meet that demand. Highlights Rural SUD counselors experience high levels of burnout and turnover. Emotional exhaustion (“burnout”) is the strongest predictor of intent to quit. Management communication and distributive justice can improve counselor retention.
The Leaking Spanish Bilingual Education Teacher Pipeline: Stories of PK-20 Challenges Told by Latinx Becoming Bilingual Teachers in the U.S.

ABSTRACT Wondering about possible reasons for the continuous shortage of bilingual teachers in the U.S., this five-year longitudinal qualitative narrative inquiry examines potential “leaks” in the pre-kindergarten to college (PK-20) Latinx bilingual teacher pipeline (BTP). We adopt Ocasio’s Latino Teacher Pipeline framework which establishes PK-20 junctures where Latinx students are at risk of premature exit. The PK-20 junctures Latinx students face when deciding to become bilingual teachers are (1) high-school graduation, (2) enrollment in higher education, and (3) college graduation and obtaining certification. By examining the educational trajectories told by three Latinx becoming novice bilingual teachers, three salient PK-20 leaks are revealed in the participant’s testimonios. One is the challenge to become and remain bilingual. Another is the facing of negative family messages toward teaching as a desirable career option. A third challenge is not feeling valued and supported in terms of their culture and bilingualism, within educational institutions including in the Bilingual Education Preparation Programs (EPP). We propose specific concerted actions among school district administrators and BEPPs to implement initiatives that forefront a commitment toward structuring and strengthening the Latinx BTP that may ameliorate the shortage of bilingual teachers.
Information Diffusion between Users in Open Data Ecosystem: Modelling and Simulation Analysis

Exploring the information interaction between users can provide a new way to solve open data ecosystem (ODE) sustainable development. In this paper, an information diffusion model, ILSOC, is proposed to analyze the information spreading among users within the ODE, and we use this model to inspect the impact on the sustainability of the ODE. First, we establish an information diffusion model that considers the public swing mentality. As a result, the relevant parameter variables are defined, and their influence is evaluated. Finally, this article proposes countermeasures to solve the sustainability problem within ODEs from the perspectives of users. Results demonstrate that (1) simply increasing the probability of interaction between users cannot effectively improve the sustainability of the ODE. (2) Parameters, such as contact rate, conversation rate, silent rate, and reversal rate, have constant effects on the ODE. (3) To maintain this ecosystem stability, some incentives and punishments for users in the public event are necessary.
Optional Subject and Students’ Academic Performance of Class IX in Samdrupcholing Dungkhag

A study was conducted to determine student’s preferences and factor influencing the choice of optional subject, to find which student perform better and mainly to analyze the effect of the optional subject on performances in Schools of Samdrupcholing Dungkhag. The survey method was used to collect data through a structured questionnaire survey. There was 220 student studying in class IX. The study showed that Class IX students generally preferred Computer Application subject. The main factors that influence the choice of an optional subject were interest on the subject followed by future career, an influence of seniors, teachers, and schools. The descriptive analysis showed that Economic student performs better than Computer Application and Environmental Science taking student. To make concrete findings on which student perform better further statistical test is required. The moderation analysis indicated significant interaction effect of Computer Application subject on performance and gender (p = .03), student type (p < .001), Day school (p = .001) and Central school (p = .07). Economic subject showed significant interaction effect on performances and parent involvement in students’ academic (p = .04), parents’ qualification (p = .004), and Central school (p = .009). Environmental Science subject showed a significant effect on performances and student type (p = .001), Day school (p = .002) and boarding school (p = .02). There is a need for further inquiry and study to include the factors like teachers, assessment mode, socio-economic factor and more to analyze the effect.
Formability Investigation of a Thin-wall Part of Double Curvature Using an Integrated Reverse Engineering Environment

ABSTRACTAn integrated reverse engineering (RE) environment composed of modeling, forming simulation, tooling design and manufacturing, and forming operation was employed to solve an existing problem, in which a thin-wall part of double curvature was not able to be physically formed without tearing and wrinkle after numerous attempts at a logistics center. This paper focuses on the formability study of this challenging part using the newly established RE environment. Forming simulation was heavily employed to explore a narrow window that ensures a successful part forming by investigating blank shape design and understanding the material flow in forming. A key factor that ensures a successful part without tearing or wrinkle was clearly suggested by forming simulations. A physical forming process that incorporates such a factor was implemented at shop floor, which produced an accurate part without tearing and wrinkle for the first time after numerous attempts. Lessons learned are presented and the feasibilit.
Hypoxia Alters the Proteome Profile and Enhances the Angiogenic Potential of Dental Pulp Stem Cell-Derived Exosomes

Dental pulp stem cells (DPSCs) and their exosomes (Exos) are effective treatments for regenerative medicine. Hypoxia was confirmed to improve the angiogenic potential of stem cells. However, the angiogenic effect and mechanism of hypoxia-preconditioned DPSC-Exos are poorly understood. We isolated exosomes from DPSCs under normoxia (Nor-Exos) and hypoxia (Hypo-Exos) and added them to human umbilical vein endothelial cells (HUVECs). HUVEC proliferation, migration and angiogenic capacity were assessed by CCK-8, transwell, tube formation assays, qRT-PCR and Western blot. iTRAQ-based proteomics and bioinformatic analysis were performed to investigate proteome profile differences between Nor-Exos and Hypo-Exos. Western blot, immunofluorescence and immunohistochemistry were used to detect the expression of lysyl oxidase-like 2 (LOXL2) in vitro and in vivo. Finally, we silenced LOXL2 in HUVECs and rescued tube formation with Hypo-Exos. Hypo-Exos enhanced HUVEC proliferation, migration and tube formation in vitro superior to Nor-Exos. The proteomics analysis identified 79 proteins with significantly different expression in Hypo-Exos, among which LOXL2 was verified as being upregulated in hypoxia-preconditioned DPSCs, Hypo-Exos, and inflamed dental pulp. Hypo-Exos partially rescued the inhibitory influence of LOXL2 silence on HUVEC tube formation. In conclusion, hypoxia enhanced the angiogenic potential of DPSCs-Exos and partially altered their proteome profile. LOXL2 is likely involved in Hypo-Exos mediated angiogenesis.
Prediction of symptoms and diseases using machine learning algorithm for health care recognition system

As a result of their surroundings and lifestyle choices, people nowadays are affected by a wide range of ailments. As a result, early disease prediction becomes crucial. Doctors, on the other hand, struggle to make accurate forecasts based on symptoms. Accuracy anticipating disease is the most challenging challenge. Machine learning plays a key part in anticipating in order to solve this difficult issue. To tackle this problem, machine learning plays a key role in disease prediction. Medical science creates vast amounts of data every year. Early patient care has benefited from the good medical data analysis because of the growing volume of data in the medical as well as healthcare professions Disease data are used in data mining to uncover new pattern information in massive volumes of medical data. Based on the clinical condition, we created a broad illness prognosis. We apply the machine learning techniques Gated Recurrent Unit (GRU) and ANFIS to accurately forecast sickness. The collecting of disease symptoms is required for disease prediction. For an accurate prognosis, this general disease prediction considers the person's lifestyle and checkup information.
Effect of temperature gradients on water migration, frost heave and thaw-settlement of a clay during freezing-thaw process

ABSTRACT During the freezing process, water migration is a decisive factor for the estimation of frost heave and thaw-settlements of fine and mixed-grain soils. One-dimensional freezing tests with and without a water supply were carried out. The influence of different temperature gradients of a saturated clay on parameters such as water intake, frost heave, and thaw-settlements is discussed here. A new approach is presented to describe the rate of water intake, which consists of three parameters. This study shows that all three parameters were influenced by the temperature gradient. This approach helps predict frost heave and thaw-settlement in cold regions.
Detection of VAMP Proteolysis by Tetanus and Botulinum Neurotoxin Type B In Vivo with a Cleavage-Specific Antibody

Tetanus and Botulinum type B neurotoxins are bacterial metalloproteases that specifically cleave the vesicle-associated membrane protein VAMP at an identical peptide bond, resulting in inhibition of neuroexocytosis. The minute amounts of these neurotoxins commonly used in experimental animals are not detectable, nor is detection of their VAMP substrate sensitive enough. The immune detection of the cleaved substrate is much more sensitive, as we have previously shown for botulinum neurotoxin type A. Here, we describe the production in rabbit of a polyclonal antibody raised versus a peptide encompassing the 13 residues C-terminal with respect to the neurotoxin cleavage site. The antibody was affinity purified and found to recognize, with high specificity and selectivity, the novel N-terminus of VAMP that becomes exposed after cleavage by tetanus toxin and botulinum toxin type B. This antibody recognizes the neoepitope not only in native and denatured VAMP but also in cultured neurons and in neurons in vivo in neurotoxin-treated mice or rats, suggesting the great potential of this novel tool to elucidate tetanus and botulinum B toxin activity in vivo.
Evaluation of Quality and Bone Microstructure Alterations in Patients with Type 2 Diabetes: A Narrative Review

Bone fragility is a common complication in subjects with type 2 diabetes mellitus (T2DM). However, traditional techniques for the evaluation of bone fragility, such as dual-energy X-ray absorptiometry (DXA), do not perform well in this population. Moreover, the Fracture Risk Assessment Tool (FRAX) usually underestimates fracture risk in T2DM. Importantly, novel technologies for the assessment of one microarchitecture in patients with T2DM, such as the trabecular bone score (TBS), high-resolution peripheral quantitative computed tomography (HR-pQCT), and microindentation, are emerging. Furthermore, different serum and urine bone biomarkers may also be useful for the evaluation of bone quality in T2DM. Hence, in this article, we summarize the limitations of conventional tools for the evaluation of bone fragility and review the current evidence on novel approaches for the assessment of quality and bone microstructure alterations in patients with T2DM.
Test rig with active damping control for the simultaneous evaluation of vibration control and energy harvesting via piezoelectric transducers

Piezoelectric transducers can be used to harvest electrical energy from structural vibrations in order to power continuously operating condition monitoring systems local to where they operate. However, excessive vibrations can compromise the safe operation of mechanical systems. Therefore, absorbers are commonly used to control vibrations. With an integrated device, the mechanical energy that otherwise would be dissipated can be converted via piezoelectric transducers. Vibration absorbers are designed to have high damping factors. Hence, the integration of transducers would lead to a low energy conversion. Efficient energy harvesters usually have low damping capabilities; therefore, they are not effective for vibration suppression. Thus, the design of an integrated device needs to consider the two conflicting requirements on the damping. This study focuses on the development of a laboratory test rig with a host structure and a vibration absorber with tunable damping via an active relative velocity feedback. A voice coil actuator is used for this purpose. To overcome the passive damping effects of the back electromagnetic force a novel voltage feedback control is proposed, which has been validated both in simulation and experimentally. The aim of this study is to have a test rig ready for the introduction of piezo-transducers and available for future experimental evaluations of the damping effect on the effectiveness of vibration reduction and energy harvesting efficiency.
Design, Development, and Evaluation of a Virtual Reality Serious Game for School Fire Preparedness Training

Immersive virtual reality (VR) is a technology that can be effective for procedural skills training through game-based simulations such as serious games. The current study describes the instructional design, development, and evaluation of the FSCHOOL fire preparedness serious game in a cave automatic virtual environment (CAVE-VR) for elementary school teachers. The main game mechanics include a storytelling scenario, enhanced realism, freedom of movement, levels, and points corresponding to the learning mechanics of instruction, action, simulation, discovery, repetition, and imitation. The game was developed in Unity 3D with the help of the Fire Dynamics Simulator and a script to emulate and visualize fire propagation. The game featured three levels to respond to school fire safety regulations and was evaluated by elementary school teachers (N = 33) in Greece. A comparative quantitative study was conducted with experimental and control groups. The results indicate that the VR serious game is appropriate for training, providing challenge, enjoyment, and mastery.
The Influence of Family Planning Pocketbook on Cadres’ Knowledge and Skills in Changing the Couples Perceptions in Special Region of Yogyakarta

BACKGROUND: The number of traditional contraceptive methods used in the National Health Insurance (JKN) era is increasing compared to the previous year. One of the contributing factors is the public’s negative perception due to the lack of information about modern family planning. Consequently, family planning cadres are needed to provide accurate information to change people’s negative perceptions of modern family planning. A guideline written in a pocketbook can help cadres provide accurate information. AIM: This study was conducted to determine the effect of the family planning pocketbook on the knowledge and skills of cadres in changing the couple’s perception about family planning. METHODS: The research design was pre-experimental with a one-group pre-test–post-test approach. The research population was 186 people who were the representatives of family planning cadres from Bantul and Yogyakarta city. The sampling technique was performed random sampling, and 90 cadres were selected. The data were analyzed using Mann–Whitney U-Test because the data not normal distributed. RESULTS: The results demonstrated that the knowledge and skill cadres were higher after receiving the family planning pocketbook with p < 0.05. There is an effect of the pocketbook on family planning services in the JKN era on cadres’ knowledge about the family planning program. CONCLUSION: The family planning pocketbook affects cadre’s knowledge and skills in changing couples of childbearing age perceptions about family planning.