Miracle-dz/UniFAR-FTUs huggingface dataset:
Association of Hydrocodone Schedule Change With Opioid Prescriptions Following Surgery

Importance In 2014, the US Drug Enforcement Administration moved hydrocodone-containing analgesics from schedule III to the more restrictive schedule II to limit prescribing and decrease nonmedical opioid use. The association of this policy change with postoperative prescribing is not well understood. Objective To examine the hypothesis that the amount of opioids prescribed following surgery is associated with the rescheduling of hydrocodone. Design, Setting, and Participants An interrupted time series analysis of outpatient opioid prescriptions was conducted to examine the trends in the amount of postoperative opioids filled before and after the schedule change. Opioid prescriptions filled between January 2012 and October 2015 were analyzed using insurance claims data from the Michigan Value Collaborative, which includes data from 75 hospitals across Michigan. A total of 21 955 adult inpatients 18 to 64 years of age who underwent 1 of 19 common elective surgical procedures and filled an opioid prescription within 14 days of discharge to home were eligible for inclusion. Main Outcomes and Measures The primary outcome was the trends in the mean amount of opioids filled in oral morphine equivalents (OMEs) for the initial postoperative prescriptions before and after the schedule change date of October 6, 2014, compared using interrupted time series and multivariable regression analyses. Secondary outcomes included the total amount of opioids filled and the refill rate for the 30-day postoperative period. Subgroup analyses were performed by hydrocodone prescriptions, nonhydrocodone prescriptions, surgical procedure, and prior opioid use. Results Data from 21 955 patients undergoing surgical procedures across 75 hospitals and 5120 prescribers were analyzed. Cohorts before and after the schedule change were equivalent with respect to sex (10 197 of 15 791 [64.6%] vs 3966 of 6169 [64.3%] female; P = .69) and mean (SE) age (47.9 [11.2] vs 47.7 [11.3] years; P = .19). After the schedule change, the mean OMEs filled in the initial opioid prescription increased by approximately 35 OMEs (&bgr; = 35.1 [13.2]; P < .01), equivalent to 7 tablets of hydrocodone (5 mg). There were no significant differences in the total OMEs filled during the 30-day postoperative period before and after the schedule change (&bgr; = 18.3 [30.5]; P = .55), but there was a significant decrease in the refill rate (&bgr; = −5.2% [1.3%]; P < .001). Conclusions and Relevance Changing hydrocodone from schedule III to schedule II was associated with an increase in the amount of opioids filled in the initial prescription following surgery. Opioid-related policies require close follow-up to identify and address early unintended effects given the multitude of competing factors that influence health care professional prescribing behaviors.
Behavioral and neurodevelopmental outcome of children after maternal allopurinol administration during suspected fetal hypoxia: 5-year follow up of the ALLO-trial

Objective To evaluate the long-term neurodevelopmental and behavioral outcome of antenatal allopurinol treatment during suspected fetal hypoxia. Study design We studied children born from women who participated in a randomized double-blind placebo controlled multicenter study (ALLO-trial). Labouring women in whom the fetus was suspected to have fetal hypoxia were randomly allocated to receive allopurinol or placebo. At 5 years of age, the children were assessed with 2 parent reported questionnaires, the Ages and Stages Questionnaire (ASQ) and the Child Behavior Checklist (CBCL). A child was marked abnormal for ASQ if it scored below 2 standard deviation under the normative mean of a reference population in at least one domain. For CBCL, a score above the cut-off value (95th percentile for narrowband scale, 85th percentile for broadband scale) in at least one scale was marked as abnormal. Results We obtained data from 138 out of the original 222 mildly asphyxiated children included in the ALLO-trial (response rate 62%, allopurinol n = 73, placebo n = 65). At 5 years of age, the number of children that scored abnormal on the ASQ were 11 (15.1%) in the allopurinol group versus 11 (9.2%) in the placebo group (relative risk (RR) 1.64, 95% confidence interval (CI): 0.64 to 4.17, p = 0.30). On CBCL 21 children (30.4%) scored abnormal in de allopurinol group versus 12 children (20.0%) in the placebo group (RR 1.52, 95% CI: 0.82 to 2.83, p = 0.18). Conclusion We found no proof that allopurinol administered to labouring women with suspected fetal hypoxia improved long-term developmental and behavioral outcome. These findings are limited due to the fact that the study was potentially underpowered. Trial registration NCT00189007 Dutch Trial Register NTR1383
Simple Detection of Cochliobolus Fungal Pathogens in Maize

Northern corn leaf spot and southern corn leaf blight caused by Cochliobolus carbonum (anamorph, Bipolaris zeicola) and Cochliobolus heterostrophus (anamorph, Bipolaris maydis), respectively, are common maize diseases in Korea. Accurate detection of plant pathogens is necessary for effective disease management. Based on the polyketide synthase gene (PKS) of Cochliobolus carbonum and the nonribosomal peptide synthetase gene (NRPS) of Cochliobolus heterostrophus, primer pairs were designed for PCR to simultaneously detect the two fungal pathogens and were specific and sensitive enough to be used for duplex PCR analysis. This duplex PCR-based method was found to be effective for diagnosing simultaneous infections from the two Cochliobolus species that display similar morphological and mycological characteristics. With this method, it is possible to prevent infections in maize by detecting infected seeds or maize and discarding them. Besides saving time and effort, early diagnosis can help to prevent infections, establish comprehensive management systems, and secure healthy seeds.
Playing 20 Question Game with Policy-Based Reinforcement Learning

The 20 Questions (Q20) game is a well known game which encourages deductive reasoning and creativity. In the game, the answerer first thinks of an object such as a famous person or a kind of animal. Then the questioner tries to guess the object by asking 20 questions. In a Q20 game system, the user is considered as the answerer while the system itself acts as the questioner which requires a good strategy of question selection to figure out the correct object and win the game. However, the optimal policy of question selection is hard to be derived due to the complexity and volatility of the game environment. In this paper, we propose a novel policy-based Reinforcement Learning (RL) method, which enables the questioner agent to learn the optimal policy of question selection through continuous interactions with users. To facilitate training, we also propose to use a reward network to estimate the more informative reward. Compared to previous methods, our RL method is robust to noisy answers and does not rely on the Knowledge Base of objects. Experimental results show that our RL method clearly outperforms an entropy-based engineering system and has competitive performance in a noisy-free simulation environment.
The non-enzymatic RAS effector RASSF7 inhibits oncogenic c-Myc function

c-Myc is a proto-oncogene controlling expression of multiple genes involved in cell growth and differentiation. Although the functional role of c-Myc as a transcriptional regulator has been intensively studied, targeting this protein in cancer remains a challenge. Here, we report a trimodal regulation of c-Myc function by the Ras effector, Ras-association domain family member 7 (RASSF7), a nonenzymatic protein modulating protein–protein interactions to regulate cell proliferation. Using HEK293T and HeLa cell lines, we provide evidence that RASSF7 destabilizes the c-Myc protein by promoting Cullin4B-mediated polyubiquitination and degradation. Furthermore, RASSF7 competed with MYC-associated factor X (MAX) in the formation of a heterodimeric complex with c-Myc and attenuated its occupancy on target gene promoters to regulate transcription. Consequently, RASSF7 inhibited c-Myc–mediated oncogenic transformation, and an inverse correlation between the expression levels of the RASSF7 and c-Myc genes was evident in human cancers. Furthermore, we found that RASSF7 interacts with c-Myc via its RA and leucine zipper (LZ) domains and LZ domain peptide is sufficient to inhibit c-Myc function, suggesting that this peptide might be used to target oncogenic c-Myc. These results unveil that RASSF7 and c-Myc are functionally linked in the control of tumorigenesis and open up potential therapeutic avenues for targeting the “undruggable” c-Myc protein in a subset of human cancers.
Clustering-Based Mobile Gateway Management in Integrated CRAHN-Cloud Network

The limited storage and computing capacity hinder the development of cognitive radio ad hoc networks (CRAHNs). To solve the problem, a new paradigm of cloud-based CRAHN has been proposed, in which a CRAHN will make use of the computation and storage resources of the cloud. This paper envisions an integrated CRAHN-cloud network architecture. In this architecture, some cognitive radio users (CUs) who satisfy the required metrics could perform as mobile gateway candidates to connect other ordinary CUs with the cloud. These mobile gateway candidates are dynamically clustered according to different related metrics. Cluster head and time-to-live value are determined in each cluster. In this paper, the gateway advertisement and discovery issues are first addressed to propose a hybrid gateway discovery mechanism. After that, a QoS-based gateway selection algorithm is proposed for each CU to select the optimal gateway. Simulations are carried out to evaluate the performance of the overall scheme, which incorporates the proposed clustering and gateway selection algorithms. The results show that the proposed scheme can achieve about 11% higher average throughput, 10% lower end-to-end delay, and 8% lower packet drop fractions compared with the existing scheme.
Deriving Local Internal Logic for Black Box Models

Despite the widespread use, machine learning methods produce black box models. It is hard to understand how features influence the model prediction. We propose a novel explanation method that explains the predictions of any classifier by analyzing the prediction change obtained by omitting relevant subsets of attribute values. The local internal logic is captured by learning a local model in the neighborhood of the prediction to explain. The explanations provided by our method are effective in detecting associations among attributes and class label.
Transcranial magnetic stimulation in migraine prophylaxis

Transcranial Magnetic Stimulation (TMS) is a non-invasive brain stimulation method used worldwide to make causality-based inferences about brain-behavior interactions, assess cortical reactivity, and map functionally relevant brain regions inducing a controlled current pulse in a specific cortical area. Clinical applications of TMS have shown promising results in the treatment of a vast number of psychiatric and neurological conditions such as headache disorders - migraine being one of the most encountered. In patients with migraine, the pharmacologic therapy is divided in urgent/ abortive treatment of the attack and prophylactic one. As first-line drugs simple analgesics and non-steroidal inflammatory are preferred. Nevertheless, many individuals continue to have attacks refractory to various prophylactic and/or abortive therapies, while others are at high risk of developing medication overuse headache. Among non-pharmacologic therapies TMS has been broadly studied as a preventive migraine treatment with good outcome results. Abbreviations: DLPFC - Dorsolateral prefrontal cortex, FDA – United States Food and Drug Administration, HF-TMS – High frequency transcranial magnetic stimulation, TMS – Transcranial magnetic stimulation, rTMS – Repetitive transcranial magnetic stimulation
Previous Cannabis Exposure Modulates the Acute Effects of Delta-9-Tetrahydrocannabinol on Attentional Salience and Fear Processing

Cannabis can induce transient psychotic and anxiety symptoms and long-lasting disorders. The acute psychoactive effects of its main active ingredient, (-)-trans-&Dgr;9-tetrahydrocannabinol (&Dgr;9-THC), may be modulated by previous cannabis exposure. Secondary data analyses tested whether modest previous cannabis exposure modulated the acute effects of &Dgr;9-THC on attentional salience and emotional processing and their neurophysiological substrates. Twenty-four healthy men participated in a double-blind, randomized, placebo-controlled, repeated-measures, within-subject, &Dgr;9-THC challenge study using fMRI. Compared with nonusers (NUs; n = 12; <5 lifetime cannabis joints smoked), abstinent-modest cannabis users (CUs; n = 12; 24.5 ± 9 lifetime cannabis joints smoked) showed less efficient attentional salience processing and recruited different/additional brain areas to process attentional salient and emotional stimuli (all ps ⩽ .01). The &Dgr;9-THC challenge disrupted attentional salience and emotional-processing-related brain activity and induced transient anxiety and psychotic symptoms (all ps ⩽ .02). However, &Dgr;9-THC-induced psychotic symptoms and attentional salience behavioral impairment were more pronounced in NUs compared with CUs (all ps ⩽ .04). Also, NUs under &Dgr;9-THC shifted toward recruitment of other brain areas to perform the tasks. Conversely, CUs were less affected by the acute challenge in an exposure-dependent manner, showing a neurophysiological pattern similar to that of NUs under placebo. Only in NUs, &Dgr;9-THC-induced psychotic symptom and cognitive impairment severity was associated with a more pronounced neurophysiological alteration (all ps ⩽ .048). In conclusion, CUs displayed residual effects of cannabis exposure but more blunted responses to the acute symptomatic, behavioral, and neurophysiological effects of &Dgr;9-THC, which were more marked in NUs.
Occurrence of the Root-Knot Nematode species in Vegetable Crops in Souss Region of Morocco

Root-knot nematodes ‘Meloidogyne spp’ are the most destructive group of plant parasitic nematodes causeing serious losses in vegetables crops and this damages worsened when crops grown under greenhouses conditions. In this sutdy, the distribution and characterization of root-knot nematode species collected from the Souss region of Morocco where vegetables crops intensively cultivated were determined by using both morphological and molecular tools. Out of the 110 samples collected from different greenhouses 91 (81.7%) were found to be infested with root-knot nematodes. Thirty-seven populations of root-knot nematodes were morphologically identified based on perineal patterns as well as molecularlly using species-specific primers. The obtained results indicated that Meloidogyne javanica and M. incognita were identified in 86.4% and 13.5% of the total populations, respectively. The lowest incidence of root-knot nematodes (64%) was found in Toussous, whereas the highest frequencies of 100% and 90% were detected in Taddart and Biogra, respectively. As the majority of the samples have been infested with Meloidogyne species; this indicates that there is an urgent need to provide farmers with a proper control strategy.
Regulating food risk management - a government-manufacturer game facing endogenous consumer demand

In the food industry, manufacturers may add some chemical additives to augment the appearance or taste of food. This may increase the food demand and sales profits, but may also cause health problems to consumers. The government could use a punishment policy to regulate and deter such risky behavior but could also benefit from economic prosperity and tax income based on their revenues. This generates a tradeoff for the government to balance tax income, punishment income, and health risks. Adapting to government regulations, the manufacturers choose the level of chemical additives, which impacts the consumer demand. To our knowledge, no prior work has studied the strategic interactions of regulating the government and the manufacturers, faced with strategic customers. This paper fills this gap by (a) building a government-manufacturer model and comparing the corresponding decentralized and centralized models; and (b) applying the 2008 Sanlu food contamination data to validate and illustrate the models.
VA MYCORRHIZAE IN STRAND VEGETATION OF HAWAII: EVIDENCE FOR LONG-DISTANCE CODISPERSAL OF PLANTS AND FUNGI.

Vesicular-arbuscular mycorrhizal fungi (VAMF) were a nearly constant component of the coastal strand of the Hawaiian Islands, occurring in beach sand, driftline debris, in roots of 23 of 31 species of vascular plants examined, and in association with rhizomes of two native species, Sporobolus virginicus and Jacquemontia sandwicensis. Mycorrhizae were most frequent and intensity of VAM development was greatest in endemic plants, less in indigenous species, and least in alien species. Spores of VAMF were produced in abundance between the rhizome and the leaf sheaths of Sporobolus. Roots of two strand species, including roots of Sporobolus that were immersed in seawater for 7 days, functioned as inocula of VAMF in pot-culture studies. The close association between propagules of VAMF and vegetative fragments of indigenous plants found in the present study suggests a mechanism of codispersal that appears to ensure the maintenance of the symbiosis in nutrient-deficient sites where it is most beneficial. The codispersal of fungus and plant may explain the high frequency of mycotrophy in strand species in the tropical Pacific.
Globalna strategia a redefinicja polityki Unii Europejskiej w jej sąsiedztwie

The immediate neighbourhood and the processes that are taking place here represent a significant challenge for the European Union from its very beginning. Recently there have been overlapping crises and transformations that have a significant impact on the whole region, but also on the shape of EU foreign and security policy. These include the armed conflict in eastern Ukraine from 2014, annexation of the Crimea by Russia, and consequently the destabilization of Ukraine itself and the whole region. The aim of the article is to answer the question of the direction of the redefinition of the European Union's foreign and security policy in its neighborhood, based on newly adopted strategic documents such as the 2016 Global Strategy of the European Union, its original version – European Security Strategy and closely related European Union Neighborhood Policy from 2015. This article will answer the basic research questions: To what extent has the European Union adopted the newly adopted Global Strategy to reformulate its role and identity in the world? , What are the bases, goals and scope of the EU’s policy change vis-a-vis its neighbourhood, both theoritical and practical? , Is the EU neighbourhood revision helpful in the context of the region’s changes?
Heterogeneity in Cognitive and Socio-Emotional Functioning in Adolescents With On-Track and Delayed School Progression

Adolescence is characterized by considerable changes in cognitive and socio-emotional skills. There are considerable differences between adolescents with regards to the development of these skills. However, most studies examine adolescents’ average functioning, without taking into account this heterogeneity. The current study applies network analysis in order to examine heterogeneity of cognitive and socio-emotional functioning in adolescents on-track or delayed in their school progression. Data was collected at two time-points for on-track (n = 320) and delayed (n = 69) adolescents (Mage = 13.30 years, SDage = 0.77). Repeated measures ANOVA showed no significant differences between the groups in cognitive and socio-emotional functioning (p’s > 0.05). Network analysis revealed that executive functions play a key role in the network of cognitive, social, and emotional functioning. This is especially the case in the delayed group where executive functions are even more central, both at T1 (inhibition and shifting) and T2 (shifting). Subsequent community analysis revealed three profiles in both groups: a well-adapted and well-balanced group, a group with high levels of need for arousal and risk-taking, and a group with regulation problems. Compared to on-track adolescents, delayed adolescents showed even higher levels of risk-taking in the second profile and higher levels of executive function problems in the third profile at T1. These differences were leveled out at T2, indicating adolescents in the delayed group catch up with their peers. This study highlights the intricate balance between cognitive, social and emotional functioning in adolescents in relation to school performance and provides preliminary evidence of the importance of taking individual differences within groups into account.
Putting false memories into context: the effects of odour contexts on correct and false recall*

ABSTRACT False memories created by the Deese/Roediger-McDermott (DRM) paradigm are often accompanied by contextual information. Yet, research investigating the effects of context on false memories is surprisingly scarce. We used the context-dependent memory (CDM) model to construct same versus different context conditions using odours as contexts and DRM lists as to-be-remembered stimuli. Experiment 1 showed that levels of correct recall were higher in the same-context condition than in the changed-context condition, but no effects of context were observed in false recall. Experiment 2 used different odours and a longer retention interval and showed that context-dependent memory effects were found for both true and false memory. For true memory, context reinstatement improved memory, whilst simultaneously reducing false memory. Theoretical and forensic implications of these findings are discussed.
Callous and uncaring traits are associated with reductions in amygdala volume among youths with varying levels of conduct problems

Abstract Background The emergence of callous unemotional (CU) traits, and associated externalizing behaviors, is believed to reflect underlying dysfunction in the amygdala. Studies of adults with CU traits or psychopathy have linked characteristic patterns of amygdala dysfunction to reduced amygdala volume, but studies in youths have not thus far found evidence of similar amygdala volume reductions. The current study examined the association between CU traits and amygdala volume by modeling CU traits and externalizing behavior as independent continuous variables, and explored the relative contributions of callous, uncaring, and unemotional traits. Methods CU traits and externalizing behavior problems were assessed in 148 youths using the Inventory of Callous Unemotional Traits (ICU) and the Child Behavior Checklist (CBCL). For a subset of participants (n = 93), high-resolution T1-weighted images were collected and volume estimates for the amygdala were extracted. Results Analyses revealed that CU traits were associated with increased externalizing behaviors and decreased bilateral amygdala volume. These results were driven by the callous and uncaring sub-factors of CU traits, with unemotional traits unrelated to either externalizing behaviors or amygdala volume. Results persisted after accounting for covariation between CU traits and externalizing behaviors. Bootstrap mediation analyses indicated that CU traits mediated the relationship between reduced amygdala volume and externalizing severity. Conclusions These findings provide evidence that callous-uncaring traits account for reduced amygdala volume among youths with conduct problems. These findings provide a framework for further investigation of abnormal amygdala development as a key causal pathway for the development of callous-uncaring traits and conduct problems.