Miracle-dz/UniFAR-FTUs huggingface dataset:
Gastrointestinal , Hepatobiliary and Pancreatic Pathology Substance P-Mediated Expression of the Pro-Angiogenic Factor CCN 1 Modulates the Course of Colitis

Substance P (SP) regulates important intestinal functions , such as mucosal permeability , motility , chloride secretion, and inflammation via the neurokinin-1 receptor (NK-1R). Previous reports showed that vascularization and expression of angiogenic factors are evident in the colonic mucosa of rats with colitis and patients with inflammatory bowel disease. Here we determined whether SP is associated with angiogenesis. Human NCM460 colonocytes stably transfected with the human NK-1R (NCM460-NK-1R cells) and mice with dextran sodium sulfate-induced colitis were used. We found that expression of the angiogenic factor CCN1 was increased in the colons of patients with Crohn’s disease and ulcerative colitis. Mucosal extracts from inflammatory bowel disease patients induced human intestinal microvascular endothelial cell migration that was inhibited by blockade of CCN1 and its receptor integrin v 3. Both the degree of angiogenesis and CCN1 expression were elevated in the colons of mice with dextran sodium sulfateinduced colitis , which was reduced by treatment with the NK-1R antagonist CJ-12255. SP also increased CCN1 expression in NCM460-NK-1R colonocytes. SP exposure to human intestinal microvascular endothelial cells co-cultured with NCM460NK-1R cells induced angiogenic activity that was inhibited by CCN1 silencing. In addition, intracolonic overexpression of CCN1 induced angiogenesis in mouse colon. Thus, SP mediates angiogenesis via CCN1 during colitis. (Am J Pathol 2008, 173:400–410; DOI: 10.2353/ajpath.2008.080222)
Interferon lambda 1 / IL-29 and inorganic polyphosphate are novel regulators of neutrophil-driven thromboinflammation Short running title : IFN-λ and PolyP in neutrophil thromboinflammation

Akrivi Chrysanthopoulou, Konstantinos Kambas, Dimitrios Stakos, Ioannis Mitroulis, Alexandros Mitsios, Veroniki Vidali, Iliana Angelidou, Magdalena Bochenek, Stella Arelaki, Athanasios Arampatzioglou, Ioanna-Evdokia Galani, Panagiotis Skendros, Elias A. Couladouros, Stavros Konstantinides, Evangelos Andreakos, Katrin Schäfer, Konstantinos Ritis. * These authors contributed equally ** These authors co-supervised the manuscript
Macroeconomic Crunches During Working Years and Health Outcomes Later in Life

We investigate the long-term effects of macroeconomic crises experienced during prime working age (20 to 50) on health outcomes later in life using data from eleven European countries. Experiencing a severe crisis in which GDP dropped by at least 1% significantly reduces health later in life. Specifically, respondents hit by such a shock rate their subjective health as worse, are more likely to suffer from chronic diseases and mobility limitations, and have lower grip strength. The effects are larger among low-educated respondents. Experiencing a crisis year decreases the probability of being in good health later in life equivalent to being two years older in the overall sample or four years older in the low-educated subsample. Highly educated respondents' health is not affected by economic crises and additionally economic booms have a positive effect on their health. An analysis of critical periods in life reveals that in particular crises experienced later in the career (between age 40 and 50) matter for health. Extensive robustness checks show that our results are not driven by general improvements in health during the post-war years.
Scale-free networks from optimal design

A large number of complex networks, both natural and artificial, share the presence of highly heterogeneous, scale-free degree distributions. A few mechanisms for the emergence of such patterns have been suggested, optimization not being one of them. In this letter we present the first evidence for the emergence of scaling (and the presence of small-world behavior) in software architecture graphs from a well-defined local optimization process. Although the rules that define the strategies involved in software engineering should lead to a tree-like structure, the final net is scale-free, perhaps reflecting the presence of conflicting constraints unavoidable in a multidimensional optimization process. The consequences for other complex networks are outlined.
Anodic Ag / TiO 2 nanotube array formation in NaOH / fluoride / ethylene glycol electrolyte as a photoanode for dye-sensitized solar cells

A layer of TiO2 nanotube (TNT) arrays with a thickness of 13 μm is synthesized by a two-step anodic oxidation from Ti metal foil. Surface charged Ag nanoparticles (NPs) are prepared by chemical reduction. After a pretreatment of the TNT arrays by acetone vapor, Ag NP filled TNT arrays can be achieved by electrophoretic deposition (EPD). Effects of the applied voltage during EPD such as DC–AC difference, frequency and waveform are investigated by quantitative analysis using atomic absorption spectroscopy. The results show that the best EPD condition is using DC 2 V+AC 4 V and a square wave of 1 Hz as the applied voltage. Back illuminated dye-sensitized solar cells are fabricated from TNT arrays with and without Ag NPs. The efficiency increased from 3.70% to 5.01% by the deposition of Ag NPs.
European Goniopholididae from the Early Albian Escucha Formation in Ariño (Teruel, Aragón, Spain)

Although goniopholidids constitute the most abundant remains of the Lower Cretaceous record of the Iberian Peninsula crocodilians, few specimens have been found complete enough to provide precise taxonomic determinations. The palaeontological site of Mina Santa María in Ariño (Teruel, Early Albian Escucha Formation) has yielded several neosuchian monotaxic concentrations. The skulls discovered at the Ariño Mine show a character combination linking them to the latter European species. The Ariño skulls share apomorphies with Anteophthalmosuchus hooleyi, Goniopholis willetti (e.g., loss of the transverse frontal crest and of the prefrontal-lachrymal crest, supratemporal fossa larger than the orbit and supratemporal fenestra subequal, among other derived characters). The new taxa, Hulkepholis plotos gen. n. , sp. n. and Anteophthalmosuchus escuchae sp. n. , are herein erected, and they constitute the most recent record of their RESUMEN A pesar de que los restos de goniofolídidos son los más abundantes del registro de cocodrilos del Cretácico Inferior de la Península Ibérica, pocos ejemplares se han descubierto lo suficientemente completos como para proporcionar determinaciones taxonómicas precisas. Las concentraciones monotáxicas de cocodrilos neosuquios descubiertas en la Mina Santa María de Ariño (Teruel, Albiense Temprano de la Formación Escucha) han proporcionado restos craneales, cuya combinación de caracteres los vincula con el clado de los Goniopholididae temporalmente más modernos. Las apomorfías compartidas (ausencia de cresta prefronto-lacrimal y de cresta frontal interorbitaria; fenestra supratemporal subigual a la órbita, siendo las fosas mucho mayores en diámetro, entre otros caracteres derivados) permiten caracterizar los dos nuevos táxones: Hulkepholis plotos gen. n. , sp. n. y Anteophthalmosuchus escuchae sp. https://doi.org/10.7203/sjp.28. 1.17835 BUSCALIONI, ALCALÁ, ESPÍLEZ & MAMPEL 104 clade in Europe. These sympatric species lived in a coastal marsh system with barrier islands and lagoon.
Determining the Motives for a Positive Optimal Tax on Capital

Previous literature demonstrates that in a computational life cycle model the optimal tax on capital is positive and large. Given the computational complexities of these overlapping generations models it is helpful to determine the relative importance of the economic factors driving this result. I highlight the impact of changing two common assumptions in a benchmark model that generates a large optimal tax on capital similar to the model in Conesa et al. (2009). First, the utility function is altered such that it implies an agent's Frisch labor supply elasticity is constant, as opposed to increasing, over his lifetime. Second, the government is allowed to tax accidental bequests at a separate rate from ordinary capital income. The main finding of this paper is that these two changes cause the optimal tax on capital to drop by almost half. Furthermore, I find that the welfare costs of adopting the high optimal tax on capital from the benchmark model in the model with the altered assumptions, which calls for a lower tax on capital, are equivalent to 0.35 percent of total lifetime consumption. Quantifying the impact of these assumptions in the benchmark model is important because the first has limited empirical evidence and the second, although included for tractability, confounds a motive for taxing capital with a motive for taxing accidental bequests.
Acute inpatient care and service users

In the UK and internationally, there are concerns for the quality of health care available to people with mental health problems. A number of surveys and reports suggest that hospital admission for acute psychiatric care can be stigmatizing and non-therapeutic. This paper describes the setting up and progress to date, of an ongoing qualitative research study carried out in Wales. The study explores service users’ subjective experience of shame before, during and after psychiatric hospital admission. The research study’s aims are to learn about situations that might influence quality of care because of shame experienced by individuals and groups of people. The study also seeks to explore specifically ways that relationships with healthcare professionals are influenced because of shame related experiences. This paper reports on phase one of the study, service users views and reviews acknowledged benefits and difficulties experienced to date. Both phases of the study encompassed mixed membership focus groups conducted by both researchers. Although the data analysis is still in progress, provisional findings of this research study suggest that an awareness of the complexities in relation to ways shame is aroused in individuals and groups of people because of mental health problems could contribute to improving the quality of care provided to service users, before, during and after hospital treatment and care. Although not initially part of the study’s intentions, the views of all focus group participants so far indicate that collaborative research is found to be empowering. Information gained to date indicates that we will gain a better understanding of situations that provoke feelings of shame in established service users and those experiencing emotional distress for the first time.
Atrial fi brillation in CKD

Article history: Received 22 February 2016 Received in revised form 7 April 2016 Accepted 9 April 2016 Available online xxxx Atrial fibrillation (AF), one of the most common dysrhythmia in clinical practice, remains frequently in people with chronic kidney disease (CKD). AF is associated with a fivefold risk of stroke, a threefold incidence of heart failure, and an increased risk of death. Co-existence of AF and CKD raises substantially morbidity and mortality. Moreover, the optimal treatment approach (rate versus rhythm control) remains debated due to lack of hard evidence. Oral anticoagulation is challenging, since these patients have both a prothrombotic state and an increased risk of stroke and an inherent platelet and vascular dysfunction and an amplified rate of bleeding. Although promising, the newer anticoagulation agents were not tested in severe CKD. Furthermore, fatal bleeding has been reported. © 2016 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
Baffle Diffraction in Interferometric Detectors of Gravitational Waves

─ This paper presents an efficient highfrequency analysis framework for studying diffraction occurring at irises, or baffles, in the arms of a FabryPerot optical interferometer, relevant to the design and operation of interferometric detectors of gravitational waves like LIGO and Virgo. Index Terms ─ Gaussian beams, gravitational wave detectors, uniform theory of diffraction.
Structural basis of the TSC 1-TBC 1 D 7 interaction 1 Structural basis of the interaction between tuberous sclerosis complex 1 ( TSC 1 ) and Tre 2-Bub 2-Cdc 16 domain family member 7 ( TBC 1 D 7 )

Mutations in TSC1 or TSC2 cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by the occurrence of benign tumors in various vital organs and tissues. TSC1 and TSC2, the TSC1 and TSC2 gene products, form the TSC protein complex that senses specific cellular growth conditions to control mTORC1 signaling. TBC1D7 is the third subunit of the TSC complex, and helps to stabilize the TSC1-TSC2 complex through its direct interaction with TSC1. Homozygous inactivation of TBC1D7 causes intellectual disability and megaencephaly. Here we report the crystal structure of a TSC1-TBC1D7 complex and biochemical characterization of the TSC1TBC1D7 interaction. TBC1D7 interacts with the C-terminal region of the predicted coiledcoil domain of TSC1. The TSC1-TBC1D7 interface is largely hydrophobic, involving the α4 helix of TBC1D7. Each TBC1D7 protein interacts simultaneously with two parallel TSC1 helices from two TSC1 molecules, suggesting that TBC1D7 may stabilize the TSC complex by tethering the C-terminal ends of two TSC1 coiled-coils.
Comparison of aeroacoustic predictions of turbulent trailing edge noise using three different flow solutions

Noise generated by turbulent flow past a sharp edge is important in the design of a variety of applications such as aircraft and wind turbines. It is therefore useful to have predictive methods that can capture the effects of subtle design changes on the flow and resulting radiated noise. In this paper, such a methodology is presented and used to predict noise from a sharp-edged strut with a turbulent boundary layer. The method is unique because it combines mean flow data from a Reynolds Averaged Navier Stokes (RANS) solution with statistical models of the turbulence to form acoustic source terms for an analytical acoustic model. Three different CFD codes (OpenFOAM, STAR-CCM+ and Fluent) are used to carry out the flow calculations, and two of the solutions are used as input to the noise prediction model. The resulting noise predictions are critically compared against each other and also with experimental data. The differences are highlighted to illustrate the sensitivity of the acoustic predictions to the RANS solution.
Channel Length Upsize for Robust and Compact Subthreshold SRAM

Subthreshold operation is an efficient way to achieve ultra-low-power consumption. However, subthreshold SRAM requires special design techniques to ensure sufficient robustness in the context of high process variability of nanoscale technologies. In this contribution, we propose to increase MOSFET channel length in the conventional 6T SRAM cell to operate safely at subthreshold Vdd. Two length upsizing schemes are proposed and we show that they lead to an efficient robustness increase with minimum area overhead (10%), thanks to DIBL and variability mitigation. We also show that the improved subthreshold swing yields a static power reduction by a factor 20 without significant speed deterioration.
Age of Onset of Physical Abuse: Implications for Adult Anger and Aggression

This study examines the impact the age of onset of physical abuse has on the expression of anger and aggression in adulthood. The Emotional and Physical Abuse Questionnaire (EPAB), State Trait Anger Expression Inventory (STAXI), Emotional Response Scenarios (ERS), and a demographics questionnaire were given to 229 undergraduate psychology students. Age of onset of abuse does predict higher levels of Trait Angry Temperament and Anger Expression Out in those whose abuse began as a child than for those whose abuse began in adolescence/ adulthood or those not abused. Further, it was determined that Hostile Attributional Bias moderated the relationship between age of onset of abuse and both Trait Angry Temperament and Anger Expression Out. The implications for the Social Information Processing theory of anger and aggression and potential therapeutic use of these findings are discussed.
UV-Induced Melanoma via Suppression of XPC Mice toV 600 ELoss of ARF Sensitizes Transgenic BRAF

Both genetic mutations and UV irradiation (UVR) can predispose individuals to melanoma. Although BRAF is the most prevalent oncogene in melanoma, the BRAF mutant is not sufficient to induce tumors in vivo. Mutation at the CDKN2A locus is another melanoma-predisposing event that can disrupt the function of both p16 and ARF. Numerous studies have focused on the role of p16 in melanoma, but the involvement of ARF, a well-known p53 activator, is still controversial. Using a transgenic BRAFmousemodel previously generated in our laboratory, we report that loss of ARF is able to enhance spontaneous melanoma formation and cause profound sensitivity to neonatal UVB exposure. Mechanistically, BRAF and ARF deletion synergize to inhibit nucleotide excision repair by epigenetically repressing XPC and inhibiting the E2F4/DP1 complex. We suggest that the deletion of ARF promotes melanomagenesis not by abrogating p53 activation but by acting in concert with BRAF to increase the load of DNA damage caused by UVR. Cancer Res; 73(14); 4337–48. 2013 AACR.
Lawrence Berkeley National Laboratory Recent Work Title Real-Time Ozone Detection Based on a Microfabricated Quartz Crystal Tuning Fork Sensor Permalink

A chemical sensor for ozone based on an array of microfabricated tuning forks is described. The tuning forks are highly sensitive and stable, with low power consumption and cost. The selective detection is based on the specific reaction of the polymer with ozone. With a mass detection limit of ~2 pg/mm and response time of 1 second, the sensor coated with a polymer sensing material can detect ppb-level ozone in air. The sensor is integrated into a miniaturized wearable device containing a detection circuit, filtration, battery and wireless communication chip, which is ideal for personal and microenvironmental chemical exposure monitoring.
No . 09-02 The compensation thesis , as exemplified by the case of the Chinese central bank by Marc Lavoie

The present paper extends the theory of demand-led money supply endogeneity to the case of an open economy with a fixed exchange rate. This case was first explored by French central bankers in the 1970s, and was called the compensation thesis. This approach can be contrasted to the Mundell-Fleming model, where interest rates are endogenous variables and where monetary policy is assessed by the money supply level. In the the compensation approach, central banks are able to set interest rates, even in a fixed exchange rate regime, either because there are automatic market mechanisms that will induce the private sector to act in such a way that changes in foreign reserves will be compensated by opposite changes in central bank claims over the domestic economy, or because the central bank will engage in endogenous sterilization operations in its efforts to keep the benchmark interest rate at the level that it sees fit. We take the case of China, with its quasi fixed exchange rate and large acquisitions of foreign reserves to provide some empirical evidence of the compensation thesis. Analyzing the balance sheet of the Chinese central bank and China's macroeconomic performance in recent years, we find that the large rise in foreign reserves on the asset side is compensated by large positive changes in items of the liability side that are unrelated to the monetary base, in particular bonds issued by the central bank. We also find that foreign reserves are not cointegrated with the money base, meaning that there is no long-run relationship between foreign reserves and the supply of base money. We also find no long-run relation between foreign reserves and the consumer price index.
Clinical Practice Guidelines Role of endoscopy in primary sclerosing cholangitis : European Society of Gastrointestinal Endoscopy ( ESGE ) and European

Journal of Hepatology 20 Received 14 February 2017; accepted 14 February 2017 q These Guidelines were developed by the EASL and the ESGE, and are published simu Clinical practice guidelines panel: Chairs: Lars Aabakken (ESGE), Tom H. Karlsen (EASL Marc Dumonceau, Martti Färkkilä, Peter Fickert, Gideon M. Hirschfield, Andrea Laghi, Mar Cyriel Y. Ponsioen, Christoph Schramm, Fredrik Swahn, Andrea Tringali, Cesare Hassan. ⇑ Corresponding author. Address: European Association for the Study of the Liver (EAS Geneva, Switzerland. Tel.: +41 (0) 22 807 03 60; fax: +41 (0) 22 328 07 24. E-mail address: easloffice@easloffice.eu.
Compressive power spectrum sensing for vibration-based output-only system identification of structural systems in the presence of noise

Motivated by the need to reduce monetary and energy consumption costs of wireless sensor networks in undertaking output-only/operational modal analysis of engineering structures, this paper considers a multi-coset analog-toinformation converter for structural system identification from acceleration response signals of white noise excited linear damped structures sampled at sub-Nyquist rates. The underlying natural frequencies, peak gains in the frequency domain, and critical damping ratios of the vibrating structures are estimated directly from the sub-Nyquist measurements and, therefore, the computationally demanding signal reconstruction step is by-passed. This is accomplished by first employing a power spectrum blind sampling (PSBS) technique for multi-band wide sense stationary stochastic processes in conjunction with deterministic non-uniform multi-coset sampling patterns derived from solving a weighted least square optimization problem. Next, modal properties are derived by the standard frequency domain peak picking algorithm. Special attention is focused on assessing the potential of the adopted PSBS technique, which poses no sparsity requirements to the sensed signals, to derive accurate estimates of modal structural system properties from noisy sub- Nyquist measurements. To this aim, sub-Nyquist sampled acceleration response signals corrupted by various levels of additive white noise pertaining to a benchmark space truss structure with closely spaced natural frequencies are obtained within an efficient Monte Carlo simulation-based framework. Accurate estimates of natural frequencies and reasonable estimates of local peak spectral ordinates and critical damping ratios are derived from measurements sampled at about 70% below the Nyquist rate and for SNR as low as 0db demonstrating that the adopted approach enjoys noise immunity.
Structure YebF Dynamics Are Required for Secretion by OmpF

Gerd Prehna,1,2 Guijin Zhang,5 Xiandi Gong,7 Marek Duszyk,6 Mark Okon,1,3,4 Lawrence P. McIntosh,1,3,4 Joel H. Weiner,5,* and Natalie C.J. Strynadka1,2,* 1Department of Biochemistry and Molecular Biology 2Center for Blood Research Life Sciences Center, 2350 Health Sciences Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada 3Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, BC V6T 1Z1, Canada 4Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada 5Membrane Protein Disease Research Group, Department of Biochemistry, 474 Medical Sciences Building, University of Alberta, Edmonton, Alberta T6G 2H7, Canada 6Department of Physiology, 746 Medical Sciences Building, University of Alberta, Edmonton, Alberta T6G 2H7, Canada 7Institute of Microelectronics, 11 Science Park Road, Singapore 117685 *Correspondence: joel.weiner@ualberta.ca (J.H.W.), natalie@byron.biochem. ubc.ca (N.C.J.S.) DOI 10.1016/j.str. 2012.04. 014