Miracle-dz/UniFAR-FTUs huggingface dataset:
Electronic Paper Displays in Hospital Operations: Proposal for Deployment and Implementation

Background Display signage is ubiquitous and essential in hospitals to serve several clerical, operational, and clinical functions, including displaying notices, providing directions, and presenting clinical information. These functions improve efficiency and patient engagement, reduce errors, and enhance the continuity of care. Over time, signage has evolved from analog approaches such as whiteboards and handwritten notices to digital displays such as liquid crystal displays, light emitting diodes, and, now, electronic ink displays. Electronic ink displays are paper-like displays that are not backlit and show content by aligning microencapsulated color beads in response to an applied electric current. Power is only required to generate content and not to retain it. These displays are very readable, with low eye strain; minimize the emission of blue light; require minimal power; and can be driven by several data sources, ranging from virtual servers to electronic health record systems. These attributes make adapting electronic ink displays to hospitals an ideal use case. Objective In this paper, we aimed to outline the use of signage and displays in hospitals with a focus on electronic ink displays. We aimed to assess the advantages and limitations of using these displays in hospitals and outline the various public-facing and patient-facing applications of electronic ink displays. Finally, we aimed to discuss the technological considerations and an implementation framework that must be followed when adopting and deploying electronic ink displays. Methods The public-facing applications of electronic ink displays include signage and way-finders, timetables for shared workspaces, and noticeboards and bulletin boards. The clinical display applications may be smaller form factors such as door signs or bedside cards. The larger, ≥40-inch form factors may be used within patient rooms or at clinical command centers as a digital whiteboard to display general information, patient and clinician information, and care plans. In all these applications, such displays could replace analog whiteboards, noticeboards, and even other digital screens. Results We are conducting pilot research projects to delineate best use cases and practices in adopting electronic ink displays in clinical settings. This will entail liaising with key stakeholders, gathering objective logistical and feasibility data, and, ultimately, quantifying and describing the effect on clinical care and patient satisfaction. Conclusions There are several use cases in a clinical setting that may lend themselves perfectly to electronic ink display use. The main considerations to be studied in this adoption are network connectivity, content management, privacy and security robustness, and detailed comparison with existing modalities. Electronic ink displays offer a superior opportunity to future-proof existing practices. There is a need for theoretical considerations and real-world testing to determine if the advantages outweigh the limitations of electronic ink displays.
Rehabilitation Principles to Consider for Anterior Cruciate Ligament Repair

Context: Injury to the anterior cruciate ligament (ACL) is among the most common orthopaedic injuries, and reconstruction of a ruptured ACL is a common orthopaedic procedure. In general, surgical intervention is necessary to restore stability to the injured knee, and to prevent meniscal damage. Along with surgery, intense postoperative physical therapy is needed to restore function to the injured extremity. ACL reconstruction (ACLR) has been the standard of care in recent decades, and advances in surgical technology have reintroduced the prospect of augmented primary repair of the native ACL via a variety of methods. Evidence Acquisition: A search of PubMed database of articles and reviews available in English was performed through 2020. The search terms ACLR, anterior cruciate ligament repair, bridge enhanced acl repair, suture anchor repair, dynamic intraligamentary stabilization, internal bracing, suture ligament augmentation, and internal brace ligament augmentation were used. Study Design: Clinical review. Level of Evidence: Level 5. Results: No exact consensus exists on effective rehabilitation protocols after ACL repair techniques, as the variation in published protocols seem even greater than the variation in those for ACLR. For some techniques such as internal bracing and dynamic interligamentary stabilization, it is likely permissible for the patients to progress to full weightbearing and discontinue bracing sooner. However, caution should be applied with regard to earlier return to sport than after ACLR as to minimize risk for retear. Conclusion: More research is needed to address how physical therapies must adapt to these innovative repair techniques. Until that is accomplished, we recommend that physical therapists understand the differences among the various ACL surgery techniques discussed here and work with the surgeons to develop a rehabilitation protocol for their mutual patients. Strength of Recommendation Taxonomy (SORT): C.
Inaccuracy of brachial blood pressure and its potential impact on treatment and aortic blood pressure estimation

Supplemental Digital Content is available in the text Objective: Although brachial cuff SBP is universally used to guide hypertension management, it can differ significantly from intraarterial SBP. We examine the potential impacts of cuff-to-intraarterial brachial SBP (bSBP) mismatch on hypertension treatment and accuracy towards central SBP. Methods: In 303 individuals, cuff bSBP (CUFF-bSBP) and central SBP were measured using a Mobil-o-Graph simultaneously to intraarterial bSBP (IA-bSBP) and aortic SBP. According to the difference between CUFF-bSBP and IA-bSBP, we identified three phenotypes: Underestimation (CUFF-bSBP < IA-bSBP by >10 mmHg); No Mismatch (CUFF-bSBP within 10 mmHg of IA-bSBP); Overestimation (CUFF-bSBP > IA-bSBP by >10 mmHg) phenotypes. Risk of overtreatment and undertreatment, and accuracy (ARTERY society criteria: mean difference ≤5 ± 8 mmHg) were determined. A multiple linear regression model was used to assess variables associated with the bSBP difference. Results: Underestimation (n = 142), No Mismatch (n = 136) and Overestimation (n = 25) phenotypes had relatively similar characteristics and CUFF-bSBP (124 ± 17, 122 ± 14, 127 ± 19 mmHg, P = 0.19) but different aortic SBP (133 ± 21, 120 ± 16, 112 ± 18 mmHg, P < 0.001). In the underestimation phenotype, 59% were at risk of undertreatment (14% in No Mismatch), whereas 50% in the Overestimation phenotype were at risk of overtreatment (17% in No Mismatch). CUFF-bSBP accurately estimated aortic SBP only in the No Mismatch Group (mean difference 1.6 ± 8.2 mmHg) whereas central BP never met the accuracy criteria. Male sex, higher height and active smoking were associated with lesser underestimation of bSBP difference. Conclusion: The brachial cuff lacks accuracy towards intraarterial BP in a significant proportion of patients, potentially leading to increased risks of BP mismanagement and inaccurate determination of central BP. This illustrates the need to improve the accuracy of cuff-based BP monitors.
Detection of Low Lithium Concentrations Using Laser-Induced Breakdown Spectroscopy (LIBS) in High-Pressure and High-Flow Conditions

This paper describes the effects of laser pulse rate and solution flow rate on the determination of lithium at high pressure for water and 2.5% sodium chloride solutions using laser-induced breakdown spectroscopy (LIBS). Preliminary studies were performed with 0–40 mg L−1 Li solutions, at ambient pressure and at 210 bar, and in static and flowing (6 mL · min−1) regimes, for a combination of four different measurement conditions. The sensitivity of calibration curves depended on the pressure and the flow rate, as well as the laser pulse rate. The sensitivity of the calibration curve increased about 10% and 18% when the pressure was changed from 1 to 210 bar for static and flowing conditions, respectively. However, an effect of flow rate at high pressure for both 2 and 10 Hz laser pulse rates was observed. At ambient pressure, the effect of flow rate was negligible, as the sensitivity of the calibration curve decreased around 2%, while at high pressure the sensitivity increased around 4% when measurements were performed in a flow regime. Therefore, it seems there is a synergistic effect between pressure and flow rate, as the sensitivity increases significantly when both changes are considered. When the pulse rate is changed from 2 to 10 Hz, the sensitivity increases 26–31%, depending on the pressure and flow conditions. For lithium detection limit studies, performed with a laser pulse energy of 2.5 mJ, repetition rate of 10 Hz, gate delay of 500 ns, gate width of 1000 ns, and 1000 accumulations, a value around 40 µg L−1 was achieved for Li solutions in pure water for all four measurement conditions, while a detection limit of about 92 µg L−1 was determined for Li in 2.5% sodium chloride solutions, when high pressure and flowing conditions were employed. The results obtained in the present work demonstrate that LIBS is a powerful tool for the determination of Li in deep ocean conditions such as those found around hydrothermal vent systems. Graphical Abstract
BAIAP2L2 is required for the maintenance of mechanotransducing stereocilia of cochlear hair cells

Stereocilia are actin‐based cell protrusions of inner ear hair cells that play an essential role in mechano‐electrical transduction (MET). Stereocilia are organized into several rows of increasing heights with the MET protein complex localized at the tips of shorter row stereocilia. At the tips of shorter row mechanotransducing stereocilia also resides a so‐called “row 2 protein complex” whose dysfunction causes degeneration of the mechanotransducing stereocilia. In the present work, we show that BAIAP2L2 is localized at the tips of shorter row stereocilia in neonatal and adult mouse cochlear hair cells. Baiap2l2 inactivation causes degeneration of the mechanotransducing stereocilia, which eventually leads to profound hearing loss in mice of either sex. Consistently, electrophysiology and FM 1‐43FX dye uptake results confirm that MET currents are compromised in Baiap2l2 knockout mice. Moreover, BAIAP2L2 binds to known row 2 complex components EPS8L2, TWF2, and CAPZB2, and the stereociliary tip localization of CAPZB2 is dependent on functional BAIAP2L2. Interestingly, BAIAP2L2 also binds to CIB2, a known MET complex component, and the stereociliary tip localization of BAIAP2L2 is abolished in Cib2 knockout mice. In conclusion, our present data suggest that BAIAP2L2 is a row 2 complex component, and is required for the maintenance of mechanotransducing stereocilia. Meanwhile, specific MET components such as CIB2 might play a direct role in stereocilia maintenance through binding to BAIAP2L2.
Oral cannabinoid preparations for the treatment of chronic migraine: a retrospective study.

OBJECTIVE To explore the effectiveness and safety of 3 oral cannabinoid preparations (FM2®, Bedrocan® and Bediol®) in the treatment of chronic migraine. DESIGN Retrospective, cohort study. SUBJECTS Patients with chronic migraine who received FM2®, Bedrocan® or Bediol® daily for the off-label treatment of their headache, up to 6 months. METHODS The number of migraine days per month, pain intensity, the number of acute medications taken per month, the number of days per month when the patient took at least one acute medication, and adverse events were recorded at baseline, 3 months, and 6 months after the start of treatment with oral cannabinoid preparations. RESULTS The number of migraine days didn't change significantly after the 3rd and the 6th month when compared to baseline (P = 0.1182). The pain intensity (P = 0.0004), the acute medication consumption (P = 0.0006) and the number of days per month in which patients took, at least, one acute medication, (P = 0.0004) significantly decreased when compared to the baseline. No significant differences were found between patients who were still taking a preventive treatment for chronic migraine and those who weren't (all P > 0.05). Different oral cannabinoid preparations displayed similar effectiveness (all P > 0.05). The AEs were mostly mild and occurred in the 43.75% of patients. CONCLUSIONS Oral cannabinoid preparations may have a role in reducing pain intensity and acute medication intake in patients with chronic migraine, but the magnitude of the effect seems modest; further studies are needed.
Myocarditis and Pericarditis After Vaccination for COVID-19.

Methods | Forty hospitals in Washington, Oregon, Montana, and Los Angeles County, California, that were part of the Providence health care system and used the same electronic medical record (EMR) were included. All patients with documented COVID-19 vaccinations administered inside the system or recorded in state registries at any time through May 25, 2021, were identified. Vaccinated patients who subsequently had emergency department or inpatient encounters with diagnoses of myocarditis, myopericarditis, or pericarditis were ascertained from EMRs (see eTables 1 and 2 in the Supplement for exclusions and definitions). The monthly rates of first-time hospital diagnoses (excluding patients with previous diagnoses in January 2018– January 2019) in January 2019 through January 2021 (prevaccine period) and February through May 2021 (vaccine period) were compared. The Wilson method was used to calculate 95% confidence intervals for single proportions. Change in incidence between periods and 95% confidence intervals for incidence were assessed using an exact rate ratio test assuming Poisson distribution, with a 2-sided P < . 05 defining statistical significance. R version 2021 statistical software (R Foundation) was used. The Providence institutional review board approved the study with a waiver of informed consent.
DrosoPhyla: Resources for Drosophilid Phylogeny and Systematics

Abstract The vinegar fly Drosophila melanogaster is a pivotal model for invertebrate development, genetics, physiology, neuroscience, and disease. The whole family Drosophilidae, which contains over 4,400 species, offers a plethora of cases for comparative and evolutionary studies. Despite a long history of phylogenetic inference, many relationships remain unresolved among the genera, subgenera, and species groups in the Drosophilidae. To clarify these relationships, we first developed a set of new genomic markers and assembled a multilocus data set of 17 genes from 704 species of Drosophilidae. We then inferred a species tree with highly supported groups for this family. Additionally, we were able to determine the phylogenetic position of some previously unplaced species. These results establish a new framework for investigating the evolution of traits in fruit flies, as well as valuable resources for systematics.
BEREAVEMENT AMONG ADULT SIBLINGS: AN EXAMINATION OF HEALTH SERVICE UTILIZATION AND MENTAL HEALTH OUTCOMES.

We aimed to examine the association of young and middle-aged sibling bereavement with use of health services and risk of developing mental health disorders over 24 months before and after sibling's death. All persons aged 18-56 years who died of illness/natural causes between 2009 and 2016 were identified in the Danish Register of Causes of Death. The study sample included 31,842 bereaved siblings and 31,842 age- and sex-matched controls. Overall, the largest effect was observed for increased use of psychological services: for women, the peak was observed four-six months after death (odds ratio [OR]=3.31, 95% confidence interval [CI] 2.85-3.85) and for men in the first three months after death (OR=2.63, 95%CI 2.06-3.36). The peak of being diagnosed in a hospitals setting with any mental disorder for women was observed in the period 13-15 months after sibling death (OR=1.52, 95%CI 1.11-2.07) and for men in the first three months after death (OR=1.75, 95%CI 1.32-2.32). Young and mid-aged adults who experienced the death of a sibling are more likely to use health services and are at risk of poorer mental health outcomes. During the bereavement process, young and mid-aged siblings are especially in need of mental health support, such as professional psychological counseling.
Macroevolutionary foundations of a recently evolved innate immune defense

Antagonistic interactions between hosts and parasites may drive the evolution of novel host defenses, or new parasite strategies. Host immunity is therefore one of the fastest evolving traits. But where do the novel immune traits come from? Here, we test for phylogenetic conservation in a rapidly evolving immune trait—peritoneal fibrosis. Peritoneal fibrosis is a costly defense against a specialist tapeworm, Schistocephalus solidus (Cestoda), expressed in some freshwater populations of threespine stickleback fish (Gasterosteus aculeatus, Perciformes). We asked whether stickleback fibrosis is a derived species‐specific trait or an ancestral immune response that was widely distributed across ray‐finned fish (Actinopterygii) only to be employed by threespine stickleback against the specialist parasite. We combined literature review on peritoneal fibrosis with a comparative experiment using either parasite‐specific, or nonspecific, immune challenge in deliberately selected species across fish tree of life. We show that ray‐finned fish are broadly, but not universally, able to induce peritoneal fibrosis when challenged with a generic stimulus (Alum adjuvant). The experimental species were, however, largely indifferent to the tapeworm antigen homogenate. Peritoneal fibrosis, thus, appears to be a common and deeply conserved fish immune response that was co‐opted by stickleback to adapt to a new selective challenge.
Crystallization experiments in rhyolitic systems: The effect of temperature cycling and starting material on crystal size distribution

Abstract One of the various problems faced in experimental petrology is the fact that most experimental products obtained by crystallization experiments are too small, making their accurate identification by electron microprobe and laser ablation analyses very difficult. This problem is magnified when a highly polymerized starting material is used for experiments at low temperature (e.g., 700–800 °C). In this study, we present the results of crystallization experiments performed using a rhyolitic starting glass in which we test the potential of temperature cycling and pre-hydrated starting material to increase crystal size and discuss the effect of those variables on the attainment of chemical equilibrium. Experiments were performed at different temperatures (725 to 815 °C) and pressures (1 and 2 kbar), under water-saturated conditions (aH2O = 1; with aH2O being the water activity). During the experiments, temperature was either constant or cycled to ±15 °C around the target temperature during the first half of the runs. We used either a pre-hydrated (7 wt% H2O) rhyolitic glass or a dry rhyolitic glass to which 7 wt% H2O was added during capsule preparation. Our results differ between 1 and 2 kbar experiments. At 1 kbar, plagioclase and orthopyroxene were the main crystalline phases affected and temperature cycling (±15 °C) did not increase the crystal size of these phases. In contrast, if only the nature of the starting material is considered (dry glass vs. pre-hydrated), the use of a pre-hydrated starting material successfully increased the overall crystal size and decreased the crystal number density. At 2 kbar, plagioclase and amphibole were the main phases and the largest crystals were also obtained when pre-hydrated starting material was used. Contrary to experiments at 1 kbar, temperature cycling also increased the overall crystal size. The different effects of temperature cycling at 1 and 2 kbar are attributed (1) to the different cation diffusivities at 1 and 2 kbar caused by different melt water concentrations and (2) the negligible effect of temperature cycling at 1 kbar (±15 °C) is explained by little dissolution of phases, so that small crystals were already too large to be completely consumed by the dissolution process in the high temperature interval. The results demonstrate that temperature oscillation (depending on the amplitude) and the nature of the starting material (pre-hydrated vs. dry glass + water) are two parameters that can contribute to increase crystal sizes in experiments with rhyolitic melts. However, we also observed that the use of a pre-hydrated starting material increased the occurrence of zoned plagioclase crystals, which may indicate that chemical equilibrium was not perfectly reached.
Développement d'un microsystème séparatif sur monolithe organique pour l'analyse des radionucléides en milieu acide nitrique

L’analyse des radionucleides est une necessite pour la gestion des matieres et dechets radioactifs liee a l’industrie nucleaire. Pour eviter les interferences et ameliorer la precision des mesures, les etapes de traitement de l’echantillon et de separations restent aujourd’hui incontournables. Elles sont cependant longues, irradiantes, difficiles a mettre en œuvre en boite a gants et produisent un volume de dechets liquides et solides significatif. L’objectif de cette these est de proposer une alternative innovante a l’utilisation des colonnes d’extraction sur phase solide dans les protocoles de separation des radionucleides en milieu nitrique concentre permettant de reduire ces dechets en fin de cycle analytique et d’automatiser ces etapes. Un premier microsysteme jetable en plastique (COC) integrant une micro-colonne separative de chromatographie d’extraction a ete concu. La phase stationnaire est un monolithe poly(AMA-co-EDMA) synthetise par photopolymerisation in situ a structure ajustable, fonctionnalisable a facon, resistant au milieu nitrique concentre. Les capacites d’echange obtenues sont de l’ordre de 150 mgU/g de monolithe pour le TBP et le melange TBP/CMPO et 280 mgU/g de monolithe pour le DAAP. Les valeurs des coefficients de partage des monolithes impregnes ont ete determinees pour U(VI), Th(IV), Eu(III) et Nd(III) pour les 3 extractants (ainsi que pour Pu(IV) dans le cas de monolithes impregnes par le TBP). La synthese du monolithe a ete transferee en microsysteme centrifuge et apres etude hydrodynamique, la separation U,Th/Eu en milieu nitrique a ete realisee sur colonne impregnee TBP en microsysteme classique puis transferee en microsysteme centrifuge.
Clinicopathologic and prognostic roles of circular RNA plasmacytoma variant translocation 1 in various cancers

ABSTRACT Objective To explore the clinicopathologic and prognostic significance of circular RNA plasmacytoma variant translocation 1 (circPVT1) in various cancers. Methods Several databases were searched for eligible studies published before March 01, 2021. The pooled odds ratios (ORs) with 95% confidence interval (95% CI) were calculated to assess the association between circPVT1 expression and prognostic outcomes of tumor including age, gender, clinical stage, tumor size, metastasis and overall survival. Begg’s funnel plots and Egger’s test were used to evaluate the publication bias. The robustness of our results was assessed using sensitivity analysis. Results Ten studies comprising a total of 878 patients with cancer were included in this meta-analysis. The results showed that the high expression of circPVT1 was significantly related to clinical stage (OR=3.44, 95% CI: 2.40-4.94, P<0.05), tumor size (OR=2.29, 95% CI: 1.38-3.79, P<0.05), metastasis (OR=2.97, 95% CI: 2.06-4.28, p<0.05) and overall survival of cancer (OR=3.30, 95% CI: 2.26-4.84, p<0.05), but not associated with age and gender of patients with tumor. No publication bias was found. Conclusions High expression of circPVT1 may predict an advanced clinical stage and poor prognosis of tumor, suggesting that circPVT1 may serve as a potential prognostic marker in cancers.