Miracle-dz/UniFAR-FTUs huggingface dataset:
A Gelatin Hydrogel to Study Endometrial Angiogenesis and Trophoblast Invasion

As the lining of the uterus and site of blastocyst implantation, the endometrium is a dynamic tissue that undergoes rapid cycles of growth, breakdown, and remodeling each menstrual cycle. Significant vascular remodeling is also driven by trophoblast cells that form the outer layer of the blastocyst. Trophoblast invasion and remodeling enhance blood flow to the embryo ahead of placentation. Insight into endometrial vascular remodeling and trophoblast invasion would provide key insights into endometrial physiology and cellular interactions critical for establishment of pregnancy. The objective for this study was to develop a tissue engineering platform to investigate processes of endometrial angiogenesis and trophoblast invasion in a 3D environment. We report adaptation of a methacrylamide-functionalized gelatin hydrogel that presents matrix stiffness in the range of the native tissue. Further, the hydrogel supports the formation of stable endometrial endothelial cell networks and attachment of a stratified endometrial epithelial cell layer, enables culture of a hormone-responsive stromal compartment, and provides the capacity to monitor the kinetics of trophoblast invasion. With these studies, we provide a series of techniques that will instruct researchers in the development of endometrial models of increasing complexity.
Financial Feasibility Study for New Investment in New Digital Product of PT Telkom Indonesia (Case Study: SKP Project)

DOI: http://dx.doi. org/10.24018/ejbmr.2020. 5.5. 558 Vol 5 | Issue 5 | October 2020 1 Abstract — SKP is an integrated stock management system application. With SKP, PT Telkom Indonesia provides solutions to business owners in the form of connectivity and services. Proper planning of business strategy is needed based on a proper feasibility study, so SKP project can generate economic benefits for PT Telkom Indonesia and all the stakeholders. SKP has not calculated the financial projections for it to proceed to the market and meet PT Telkom Indonesia regulation. A financial feasibility study would measure the revenue projection, and cost structure such as cash flow, balance sheet, and income statement projection. At the end of this model, there will be a conclusion of the feasibility of the project using internal rate of return (IRR), net present value (NPV), and payback period (PP) as parameters. If the project is feasible, there will be a sensitivity risk analysis to find out the most sensitive variable. According to feasibility test result, it is concluded that the SKP project can benefit PT Telkom Indonesia. This can be seen from the FCFF calculation which results in a positive NPV with a value of Rp 5.229. 648.128, and IRR of 67,26% which is greater than the project WACC of 17,94%. From the payback period requirements set by PT Telkom Indonesia, the project is estimated to have a PP of 2,02 years. The result of SKP's financial projections is also supported by Monte Carlo simulations which show the effect of changes to influential variables, with simulation results show a possible NPV> 0 of 87,53%.
E-health applications in the field of traumatic stress

ABSTRACT E-health offers great potential in the field of traumatic stress to deliver training, assessment, prevention, and treatment of adverse outcomes after trauma worldwide. In order to encourage research on E-health applications in the field of traumatic stress, this current special issue of the European Journal of Psychotraumatology presents a series of papers divided into three emergent topics: I) development of digital interventions, II) the use of digital interventions to foster self-management and deliver therapy, and III) digital methods to improve prediction, assessment, and monitoring of post-trauma outcomes. These studies show acceptance of the tools by various end-user groups and improvements of current research and clinical practices, but also areas for improvement regarding the development process and making even better use of technological capabilities of E-Health. We propose three general themes to accelerate the quality of e-Health interventions and studies in this area in the coming years: optimizing user engagement and adherence, conducting more (innovative) research, and increasing implementation and dissemination activities. This issue appears in the midst of the COVID-19 pandemic. It is exactly at times like these that we need effective online interventions and we see an enormous increase in the use of e-Health. We hope this issue will contribute to help those affected and to serve the community worldwide.
Varying the spatial arrangement of synthetic herbivore‐induced plant volatiles and companion plants to improve conservation biological control

1. Conservation biological control aims to control pests by promoting wild populations of natural enemies. One challenge is to attract and retain efficient natural enemies in crop fields, which often are a suboptimal environment. Towards this goal, the at-tract-and-reward strategy relies on combining attractive synthetically produced herbivore- induced plant volatiles (HIPVs) with companion plants (non- crop plants which provide alternative resources to the targeted natural enemies). Although se-verely overlooked, the spatial arrangement of HIPV dispensers and rewards inside crop fields may strongly influence the foraging behaviour and persistence of natural enemies and thus the success of this pest management strategy. 2. We tested the impact of two contrasting spatial arrangements of HIPV dispensers and rewards, alternatively inside and around a block of target apple trees, on the efficacy of the biological control of Aphis citricola populations by the common predatory ladybird Propylea japonica in apple orchards in northern China. We used synthetic methyl salicylate (MeSA) as an attractant and the companion plant Calendula officinalis as a reward. To better understand how the spatial arrange ment of MeSA dispensers and companion plants affected the attraction and foraging behaviour of adult ladybirds, we conducted indoor experiments in a flight mill, an olfactometer and a wind- tunnel. 3. Blocks of target trees treated with MeSA dispensers inside and companion plants around provided the most efficient pest control in orchards, compared with the opposite spatial arrangement. 4. The synthetic MeSA dispenser and the companion plant synergistically attracted ladybirds in the olfactometer and enhanced their flight activity in the flight mill. In the wind- tunnel, MeSA served as a spatial cue for ladybirds to find nearby prey, while companion plants were sought in the absence of prey. 5. Synthesis and applications . This study aims to further improve aphid control in apple orchards through a careful spatial arrangement of herbivore- induced plant volatiles dispensers (HIPVs) and rewards (companion plants) in optimized
Hydrological Extremes in the Canadian Prairies in the Last Decade due to the ENSO Teleconnection—A Comparative Case Study Using WRF

In the Prairie provinces of Alberta, Saskatchewan, and Manitoba, agricultural production depends on winter and spring precipitation. There is large interannual variability related to the teleconnection between the regional hydroclimate and El Niño and La Niña in the Tropical Pacific. A modeling experiment was conducted to simulate climatic and hydrological parameters in the Canadian Prairie region during strong El Niño and La Niña events of the last decade in 2015–2016 and 2010–2011, respectively. The National Center for Atmospheric Research (NCAR) Weather Research and Forecasting (WRF) model was employed to perform two sets of sensitivity experiments with a nested domain at 10 km resolution using the European Centre for Medium-Range Weather Forecasts Reanalysis (ERA) interim data as the lateral boundary forcing. Analysis of the hourly model output provides a detailed simulation of the drier winter, with less soil moisture in the following spring, during the 2015–2016 El Niño and a wet winter during the La Niña of 2010–2011. The high-resolution WRF simulation of these recent weather events agrees well with observations from weather stations and water gauges. Therefore, we were able to take advantage of the WRF model to simulate recent weather with high spatial and temporal resolution and thus study the changes in hydrometeorological parameters across the Prairie during the two extreme hydrological events of the last decade.
Development of chloroplast microsatellite markers for identification of Glycyrrhiza species

Abstract Licorice (Glycyrrhiza glabra) is an important medicinal herb and has long been used in traditional medicine for the treatment of several diseases worldwide. Understanding the genetic diversity within Glycyrrhiza species is important for the efficient conservation of these medicinal herbs. In this study, we have developed 20 polymorphic chloroplast microsatellite (cpSSR) markers using the chloroplast genome of G. lepidota. The cpSSR markers were tested on a total of 27 Glycyrrhiza individual plants. The number of alleles per locus ranged from two to eight among the Glycyrrhiza accessions. Overall, the Shannon index (I) for each cpSSR ranged from 0.315 to 1.694, the diversity indices (h) were 0.140–0.793 and the unbiased diversity indices (uh) were 0.145–0.825. In addition, the cpSSR markers were successfully divided and classified the 27 Glycyrrhiza individuals into four groups. The cpSSR markers developed in this study could be used in the assessment of genetic diversity and rapid identification of Glycyrrhiza species.
Low synchronization Gram–Schmidt and generalized minimal residual algorithms

The Gram–Schmidt process uses orthogonal projection to construct the A = QR factorization of a matrix. When Q has linearly independent columns, the operator P = I − Q(QTQ)−1QT defines an orthogonal projection onto Q⊥. In finite precision, Q loses orthogonality as the factorization progresses. A family of approximate projections is derived with the form P = I − QTQT, with correction matrix T. When T = (QTQ)−1, and T is triangular, it is postulated that the best achievable orthogonality is 𝒪(ε)κ(A) . We present new variants of modified (MGS) and classical Gram–Schmidt algorithms that require one global reduction step. An interesting form of the projector leads to a compact WY representation for MGS. In particular, the inverse compact WY MGS algorithm is equivalent to a lower triangular solve. Our main contribution is to introduce a backward normalization lag into the compact WY representation, resulting in a 𝒪(ε)κ([r0,AVm]) stable Generalized Minimal Residual Method (GMRES) algorithm that requires only one global reduce per iteration. Further improvements in performance are achieved by accelerating GMRES on GPUs.
Temporal Dynamics of Fish Assemblages as a Reflection of Policy Shift from Fishing Concession to Co-Management in One of the World’s Largest Tropical Flood Pulse Fisheries

Inland fisheries management in Cambodia has undergone two major policy reforms over the last two decades. These reforms led to the abolishment of a century-old commercial fishing lot system in 2012 and the establishment of new fish sanctuary and community fishing areas. However, the status of fisheries and fish assemblages following the reforms is not well understood. Here, we investigated the temporal changes in fish catch weight and fish assemblage structure for the period 1995–2000 before fishing lot abolishment (BLA) and for the period 2012–2015 after the removal of all fishing lots (after lot abolishment-ALA) using time-series fish catch data recorded from the Tonle Sap Lake (TSL), one of the world largest inland fisheries. We found (i) mean catch trends vary seasonally, with stable catch trends during the BLA and decreasing catch trends during the ALA and (ii) significant shifts in fish assemblage composition, notably a shift from large-bodied, migratory, and/or predatory species during the BLA toward more short-distance migratory and/or floodplain, small-bodied species during the ALA. Fishing lot abolishment coincided with substantial changes to floodplain habitats and increases in fishing pressure, threatening TSL fish stocks. Flow alterations caused by dams and climate change may exacerbate the problem. Therefore, to realize the fisheries reform objectives, it is imperative to strengthen the fisheries’ governance and management system, including effective law enforcement, institutional strengthening, improved planning, cooperation, and coordination as well as clearly defined roles and responsibilities among concerned stakeholders at all levels.
Cumulative effect of thidiazuron and 1-naphthylacetic acid in massive root proliferation of micropropagated sugarcane plantlet

: Thidiazuron (TDZ), a well known plant growth regulator is used in tissues culture as a sup-plement to the basal MS medium. Several reports suggest the role of TDZ in promoting plant organogenesis and plant regeneration. Our experiments to micropropagate the sugarcane using various growth regulators reveal the role of TDZ in rooting and survival of a high yielding new sugarcane variety Co 05011. Various permutation combinations were tried using TDZ as the main regulator to rapidly in-crease the number of plantlets. Shoot cultures were repeatedly multiplied for 10 cycles and then transferred to MS medium augmented with various concentration of TDZ along with 1-naphthylacetic acid (NAA) and sucrose for rooting. Results of present study indicate optimum concentration of TDZ (0.002 mg/L) in combination with NAA (0.5 mg/L) resulted in 93.6% root formation. Moreover, when these shoots were re-cultured in the same media for an-other two cycles it produced 100% rooting and had almost 100% survival during acclimatization. These results indicate that TDZ and NAA combination enhance the activity of NAA and resulting in massive proliferation of roots. TDZ increases the frequency and proliferation of healthy and vigorous roots in micropropagated shoots thus enhancing their survival rate in field and during hardening process. This work can be helpful in developing successful and cost effective tissue culture of elite sugarcane varieties.
Metal Binding to Aβ Peptides Inhibits Interaction with Cytochrome c: Insights from Abiological Constructs

Aβ(1–40) peptide is mutated to introduce cysteine residue to allow formation of organized self-assembled monolayers (SAMs) on Au electrodes. Three mutants of this peptide are produced, which vary in the position of the inserted cysteine residue. Fourier transform infrared data on these peptide SAMs show the presence of both α helices and β sheet in these Aβ constructs. These peptide constructs interact with cytochrome c (Cytc), allowing electron transfer between Cytc and the electrode via the Aβ peptides. Binding of metals like Zn2+ or Cu2+ induces changes in the morphologies of these assemblies, making them fold, which inhibits their spontaneous interaction with Cytc.
The Effect of the combination of active vestibular interventions and occupational therapy on Balance in Children with Bilateral Spastic Cerebral Palsy: A pilot randomized Controlled trial

Objective The current study aimed to examine the effect of the combined administration of active vestibular interventions and occupational therapy on balance and the relationship between balance changes and Activity of Daily Living in school-aged children with cerebral palsy (CP). Materials & Methods Twenty-four children with Spastic CP, at the level I and II (according to the “Gross Motor Function Classification System) aged 7-12 years were enrolled and randomly assigned into control and intervention groups. Pediatric Balance Scales and Bruininks-Oseretsky Test of Motor Proficiency II were employed to assess the functional balance changes as well as Force Plate (eyes closed and open) to assess changes in the parameters of balance (e.g. center of pressure excursion). The activity of Daily Living was assessed by “Activity Scales for Kids (performance version)”. Participants in the intervention group received active vestibular intervention for 20 min and a regular occupational therapy program for 25 min. The control group received a regular occupational therapy program for 45 min. Interventions were provided 3 d/week for 6 weeks in each group. The participants were assessed in three stages: baseline, immediately after, and eight weeks after the intervention. Data were analyzed by ANOVA and linear regression. Results The results demonstrated that only functional balance, according to Pediatric Balance Scales scores, was significantly increased in the active vestibular interventions group (p=0.02). There was no significant association between functional balance and Activity of Daily Living (P>0.05). Conclusion The combined administration of active vestibular interventions and occupational therapy could improve the functional balance in children with spastic CP. It may be related to the reorganization of the vestibular system with a controlled and precise application of stimuli.
Seasonal Temperature Fluctuations Differently Affect the Immune and Biochemical Parameters of Diploid and Triploid Oncorhynchus mykiss Cage-Cultured in Temperate Latitudes

In the coming decades, and despite advances in the selection of resistant strains and the production of triploid organisms, the temperature could seriously affect salmonid aquaculture. Lower environmental tolerance has been hinted at for triploids, but the physiological mechanisms leading to such differences, and whether they are translated to the individual level, are poorly understood. This study aimed to evaluate the effects of seasonal variations on the humoral and immune status in the blood (peripheral blood leukocytes) and plasma (antiprotease, lysozyme and peroxidase activities), the oxidative stress (catalase, glutathione-S-transferase, total glutathione and lipid peroxidation) balance in the liver, and the energy budget (sugars, lipids, proteins and energy production) in the liver and muscle of diploid and triploid Oncorhynchus mykiss . Leukocytes’ numbers changed with the water temperature and differed between fish ploidies. Peroxidase activity was increased in the summer, but lysozyme and antiprotease activities were increased in the winter. Concomitantly, antioxidant defenses were significantly altered seasonally, increasing oxidative damage at higher temperatures. Moreover, warmer waters induced a reduction in the energy production measured in the liver. Differences in feed efficiency, which have been previously reported, were confirmed by the low lipid and protein contents of the muscle of the triploids. In sum, the inherent trade-offs to deal with the seasonal changes culminated in the higher growth observed for diploid fish.
Democracy and Depression: A Cross-National Study of Depressive Symptoms and Nonparticipation

Depression is the most common mental health disorder. It has consequences not only on individuals but also on social and political levels. We argue that depressive symptoms impair political participation by reducing the motivation and physical energy of sufferers. We test our hypotheses by conducting regression analyses of four nationally representative cross-sectional and longitudinal surveys that collectively span many democracies. Our results are threefold. First, we find that the severest depressive symptoms lower the probability of voting by 0.05–0.25 points, an effect that is exceeded only by education and age. Second, we show that depressive symptoms negatively affect political interest and internal efficacy, thereby confirming that they diminish political motivation. Third, we find that depressive symptoms most strongly affect physically demanding acts, thereby confirming that they reduce the physical energy required for participation. We conclude by urging scholars to take depressive symptoms seriously in the study of political behavior.
Probable alterations in fecal bacterial microbiota by somatostatin receptor analogs in acromegaly

Abstract Objective Data on bacterial diversity and microbiota alterations in acromegaly are currently lacking. The effects of somatostatin receptor analogs on gut microbiota remain unknown. The objective of this study was to determine microbiota alterations in patients with acromegaly and to assess the effects of somatostatin receptor analogs on gut microbiota. Methods The study was designed as a cross-sectional case-control research and three cohorts, comprising individuals with acromegaly without medical therapy (n=5), acromegaly receiving octreotide acetate (OCT) (n=8) and healthy controls (n=5), were evaluated. Results No statistically-supported changes in Bacteroidetes, Firmicutes, Proteobacteria and Actinobacteria abundance were observed. Bacteroidaceae, Odoribacteraceae, Porphyromonadaceae, Prevotellaceae and Alistipes families of Bacteroidetes and Bifidobacterium genus of the Actinobacteria phyla were detected, without overt differences. Variations in Clostridia, Erysipelotrichaceae and Veillonellaceae were not significant, while Lactobacillales were increased in individuals receiving OCT. Moreover, Akkermansia mucinophila was present in patients under OCT treatment. Conclusion Our preliminary results suggest that the bacterial community profile under OCT treatment may facilitate a colonic microenvironment for improved glucose metabolism. Alterations in the gut microbiota may be a factor affecting diabetes development during somatostatin analog treatment in acromegalic patients.
Effect of environmental management accounting practices on organizational performance: role of process innovation as a mediating variable

PurposeThis study aims to determine (1) the effect of environmental management accounting on organizational performance and (2) the mediating effect of process innovation on the relationship between environmental management accounting and organizational performance.Design/methodology/approachThis research uses survey methods designed for management accountants of large manufacturing companies in Indonesia. Data from 123 respondents were analyzed using the WarpPLS.FindingsThe implementation of environmental management accounting exerted a positive effect on organizational performance. It is evident that the implementation of environmental management accounting encourages companies to innovate processes which will improve how well the organization performs.Research limitations/implicationsThese findings still contained several limitations such as data were only collected from one province in Indonesia, and so the findings might not be generalizable to other provinces in Indonesia. Also, the number of variables studied only involved three. The study only focused on certain dimensions of environmental management accounting without considering other dimensions in-depth.Practical implicationsThese findings extend the literature on environmental management accounting and demonstrate, from a practical perspective, environmental management accounting (EMA), which prioritizes the environment, will encourage companies to innovate their processes so that they are more environmentally friendly; EMA recognizes the important role of accountants in managing environmental issues.Originality/valueThis study documents the importance of environmental management accounting to assist companies in getting accurate information on environmental issues and environmental costs.