Miracle-dz/UniFAR-FTUs huggingface dataset:
International Journal of Social Science and Economic Research

The aim of this study to classify the predictor variables and to observe the independent and group effect of physiological and fitness variables on BMD, to find out the effect of resistance exercise on Bone Mineral Density, other physiological and fitness variables. Total 34 subjects of three different age group viz. young adult (30 – 39 yr.), middle aged adult (40 – 49 yr.), and older adult (> 50 yr.) women were complete the training programme. Forced Vital Capacity was measured through Spirometer. OSTA score was used to predict the BMD risk factors. Distal radius site BMD measured through Quantity Ultrasound. Physical functioning test included grip strength, isometric back strength, balance, proprioceptive ability and gait velocity. The 17 weeks elastic resistance-training conducted 8 – 10 exercise, 70 min/session, 3 days/week, 8 repetitions and 3 sets with 20 – 30 sec recoveries. According to adaptation of the load, repetitions and resistance level were changed. For statistical analysis, one way ANCOVA, Paired sample t test, Factor Analysis and linear regression analysis were computed. The value of Physiological Condition (t = 8.229, P<0.01) and Fitness Condition (t = 3.287, P < 0.01) were significant. OSTA Index (t = 2.622, P < 0.05) and velocity gait (t = -2.231, P < 0.05) independently predict the status of BMD significantly. It was concluded that the training programme was effective for all age groups of women specifically for olderly adult women and BMD may be improved by the improvement of selected physiological and fitness factors.
Open-Domain Dialogue Generation: Presence, Limitation and Future Directions

Dialogue systems have received more and more attention from researchers, especially open-domain dialogue generation system. The application scenario of it, also chat-bot, is very extensive, from website customer service to dialogue robot such as Siri and Microsoft Xiaoice. More and more studies have been done on open-domain dialogue generation. In recent years, deep learning is gradually emerging which can leverage a massive amount of data to learn meaningful feature representations. In this paper, we first give the development of deep learning in Natural Language Processing(NLP) especially in dialogue generation. Next we analyze the current problems and introduce several improvements which are the current research hotspot. The purpose of this paper is to sort out the research results of recent years and make contributions to the research and development of the dialogue system in the future.
Key Success of Technology Acceptance to Develop Mobile Application

The development of mobile applications continues to require a high level of awareness among researchers due to their proliferation and widespread use, particularly in the context of the development of mobile applications of higher educational institutions. Their weak understanding and use, though, is empirical. Subsequently, in-depth analyses are needed to understand the reasons behind the poor adoption and growth of mobile applications. The goal of this research was, therefore, to empirically investigate the acceptance of the design of mobile applications with a proposed model built from the Unified Theory of Acceptance and Use of Technology (UTAUT). This study provides critical success on the acceptance of mobile application growth. Researchers have developed a proposed inner hierarchy of performance expectancy, effort expectancy, social network, interface design and functionality for the creation of the 21st century mobile app for learners. Educational theory is based on a scientific process known as a systematic review of the literature. After that, in the 21st century, students in Thailand paid attention to the emerging growth of mobile applications as a result of an additional requirement in line with technological progress for tertiary education in the country. The findings support as a guide for effective decision-making in the design and development of mobile applications. In turn, the findings can be used in the resource allocation phase to ensure the success of the goal and purpose of the mobile application. As a consequence, the mindset of pupils has been shown to play a vital role in leading to the growth of the 21st century mobile application for learners. The outcome of this analysis is expected to improve and update the design of a mobile application that will be useful to the needs of students in the 21st century.
Intensive Filtering-Based method in Online Social Voting

: Recommended system that predicts or suggests the content to the user supported the past searches and supported the opposite user's behavior. With the recognition of the social network, the social recommender system has gained the momentum of analysis among the researchers and social scientist. Social choice is one amongst the new rising options. Social choice is employed by each e-commerce and political organizations. Political organizations use it to investigate the end result of the election result. Ecommerce uses it to spice up their services and business. The paper essentially speaks a lot of regarding cooperative filtering in specific and normally regarding the social recommender systems. It discusses the social choice recommendation system in radio frequency and NN based mostly approaches. The paper provides a summarize context of the techniques and challenges within the collaborating filtering.
A time-resolved near-infrared spectroscopy based on CMOS image sensor

Time-resolved (TR) near-infrared spectroscopy (NIRS) offers non-invasive clinical applications in monitoring the blood oxygenation, where absolute values of oxygenated and deoxygenated hemoglobin, and absorption and scattering coefficient, can be obtained. Various detectors have been utilized to realize a TR-NIRS system, such as PMT, SiPM, and SPAD. This paper proposed a prototype NIRS device implemented using a 128 x 128 lock-in pixel CMOS image sensor (CIS) based on the lateral electric field-charge modulator (LEFM) to achieve high time resolution. Preliminary experiments based on the reflectance of an agar phantom with varying absorption coefficient have been conducted and the ability to detect the changes in the absorption coefficient has been demonstrated. The reflectance of the agar phantom is directly observed by the image sensor, which was operated at a time-window of 900 ps with a sensor detection area of 2.9mm2 . The results suggest that a NIRS device using CIS is feasible, which opens the potential of a miniature wearable time-resolved NIRS device.
Exclusion-Net: Accurate Detection Algorithm for Crowd Objects

Nowadays, the object detection algorithms have been widely used in many scenarios, but the accurate detection of crowd objectives in real-life scenarios is still a challenging problem, such as the detection problem of single human in a crowded scene, and vehicle positioning with multiple similar license plates (domestic Guangdong, Hong Kong and Macao license plates). Aiming at this kind of scenario, we designs a network structure based on multi-scale features. In addition, we also propose a new bounding box regression method with crowd multi-objectives, which has a significant improvement on the detection effect of crowd objectives. The network structure (Exclusion-Net) proposed in this paper, with very few parameters (1000K), achieves SOTA results on the VOC2007 public dataset and the Guangdong, Hong Kong and Macao license plate dataset of the actual traffic scene. On the NVIDIA 1080 graphics card, the running speed of our model can reach 40 FPS, which is easy to deploy on embedded devices.
CLONAL SPREAD OF YERSINIA ENTEROCOLITICA 1B/O:8 IN MULTIPLE ZOO SPECIES

Abstract: Yersinia enterocolitica (YE) bioserotype 1B/O:8 (YE 1B/O:8) was identified in routine culture of a variety of zoo species housed at Omaha's Henry Doorly Zoo and Aquarium (OHDZA) from April to July 2011. Animal cases representing 12 species had YE detected from 34 cases during routine fecal monitoring and/or during postmortem examination: Coquerel's sifakas (Propithecus coquereli, two cases), black & white (BW) ruffed lemurs (Varecia variegata variegata, six cases), red ruffed lemurs (Varecia rubra, seven cases), white handed gibbon (Hylobates lar albimana, one case), black lemurs (Eulemur macaco, three cases), mongoose lemurs (Eulemur mongoz, two cases), African hunting dogs (Lycaon pictus, five cases), agile gibbons (Hylobates agilis, three cases), siamangs (Hylobates syndactylus, two cases), colobus monkey (Colobus angolensis palliates, one case), argus pheasant (Argusianus argus, one case), and orangutan (Pongo pygmaeus, one case). Most species were not symptomatic; however, three symptomatic cases in Coquerel's sifakas (two) and a white handed gibbon (one) showed clinical signs of diarrhea and lethargy that resulted in death for the Coquerel's sifakas. One unexpected death also occurred in a BW ruffed lemur. To the authors' knowledge, this is the first report of YE 1B/O:8 in such a large variety of zoo species. The source of the YE could not be identified, prompting the initiation of a diseases surveillance program to prevent further cases for the species that are sensitive to YE. To date, no additional cases have been identified, thus suggesting a single introduction of the YE 1B/O:8 strain into the zoo environment.
School Refusal or Truancy? A Qualitative Study of Misconceptions Among School Personnel About Absenteeism of Children From Immigrant Families

Background School refusal is a form of school attendance problem (SAP) distinct from truancy, school withdrawal, and school exclusion; it requires specific mental health care. Schools' identification and referral to care of school refusers depends on school personnel's interpretation of the reasons for absences. Because cultural factors can induce misunderstanding of the young people's behavior and of their parents' attitudes toward school attendance, school personnel can have difficulty understanding these reasons for children with transcultural backgrounds (migrants or children of migrants). The aim of this study was to explore the experiences and opinions of school personnel, mainly teachers, related to school refusal among these students. Methods Grounded theory methodology was used to conduct 52 qualitative interviews of school personnel in two regions of France. Their daily practices with students presenting with school refusal were addressed in general (i.e., in response to absence of all youth) and in transcultural contexts (i.e., absence of migrant children or children of migrants). This study analyzed the interviews of the 30 participants who reported working with students from transcultural backgrounds. Results Many school personnel reported experiencing difficulties, ambivalence, and destabilizing feelings in situations involving immigrant families whose school culture differed from their own. Talking about culture appeared to be taboo for most participants. These situations challenged the participants' usual strategies and forced them to devise new ones to deal with these young people and their families. Although some personnel were at risk of developing exclusionary attitudes, others dealt with school refusal with both commitment and creativity. Conclusion The tensions experienced by these participants reveal contradictions between the French universalist ideology and the reality of daily life in schools becoming increasingly multicultural. School personnel's attitudes toward children with transcultural backgrounds presenting with school refusal can affect children's access to care and shape social inequalities. Further research should develop, implement, and assess interventions including transcultural training of school personnel, improved use of interpreters at school for migrant families, and the addition of a transcultural dimension to SAP assessment scales, especially for school refusal.
NMR Structure and Dynamics of TonB Investigated by Scar-Less Segmental Isotopic Labeling Using a Salt-Inducible Split Intein

The growing understanding of partially unfolded proteins increasingly points to their biological relevance in allosteric regulation, complex formation, and protein design. However, the structural characterization of disordered proteins remains challenging. NMR methods can access both the dynamics and structures of such proteins, yet suffering from a high degeneracy of NMR signals. Here, we overcame this bottleneck utilizing a salt-inducible split intein to produce segmentally isotope-labeled samples with the native sequence, including the ligation junction. With this technique, we investigated the NMR structure and conformational dynamics of TonB from Helicobacter pylori in the presence of a proline-rich low complexity region. Spin relaxation experiments suggest that the several nano-second time scale dynamics of the C-terminal domain (CTD) is almost independent of the faster pico-to-nanosecond dynamics of the low complexity central region (LCCR). Our results demonstrate the utility of segmental isotopic labeling for proteins with heterogenous dynamics such as TonB and could advance NMR studies of other partially unfolded proteins.
Detection of Diseases in Oil Palm Plantations in the Brazilian Amazon through Orbital Image

The detection of diseases in oil palm crops in the Brazilian Amazon represents a great challenge for the management of this crop in Brazil. The plantations in the State of Para provide inputs for the food, cosmetics, agro-energy and biofuel industries, supplying Brazilian markets. In recent years, several factors such as pests, diseases and climate have interfered in the development of oil palm in the region, generating the need to adopt new techniques to detect and monitor such issues. In this work, spectral enhancements were carried out by simple reflectance and vegetation indices for four plots cropped on Companhia Palmares da Amazonia (CPA) farm, owned by Agropalma S.A. company in the municipality of Acara, in the state of Para. The results allowed the identification of expressive patterns minimum and maximum reflectances of the studied plots, correlating with occurrences of diseases. The EVI index showed an excellent correlation with the occurrence of diseases. However, the NDVI and SAVI indexes showed adequate adjustments with the occurrence of diseases in 2017. The areas corresponding to the L36 and H27 plots showed higher occurrences of diseases, based on the analysis of reflectance through vegetation indices. It is concluded that the reflectance enhancements, NDVI, SAVI and EVI obtained by orbital sensors are efficient in the detection of diseases in the plots. The results allowed the identification of diagnostic anomalies of stresses in the plots, either by disease or other factor, allowing the decision making in an adequate time, therefore avoiding large scale eradication in the extensive areas in commercial palm oil plantations in Brazil.
Anticoagulants Interfere With the Angiogenic and Regenerative Responses Mediated by Platelets

Background and aims Platelet rich plasma (PRP) obtained from blood anticoagulated with acid-citrate-dextrose (ACD) or sodium-citrate (SC) is used for regenerative medicine as source of platelet-derived growth factors. Allergic reactions against citrate were reported in patients after local injection of PRP allowing us to hypothesize that anticoagulants exert a harmful and local effect that interferes with the regenerative proprieties of platelets. Herein we test this hypothesis by analyzing the effect of ACD and SC on angiogenic and regenerative responses mediated by platelets. Methods PRP was obtained from SC- or ACD-anticoagulated blood; platelets were lysed to release growth factors; and PRP releasates (PRPr) were used to induce in vitro endothelial proliferation and 2D-migration, and regeneration of mouse skin wounds. Results We first compared proliferation and migration of endothelial cells mediated by anticoagulated-PRPr supplemented or not with CaCl2. Alteration of endothelial adhesion and impediment of proliferation and migration was observed without CaCl2. Although endothelial morphology was normalized in SC- and ACD-PRPr after calcium restitution, angiogenic responses were only markedly induced by SC-PRPr. In vivo studies revealed a delay in mouse skin regeneration after treatment with anticoagulated-PRPr without CaCl2. Healing was only induced after calcium restitution in SC- but ACD-PRPr. Moreover, the development of inflammatory intradermal papules was evidenced after injection of ACD-PRPr. Supplementation of SC-PRPr with the equivalent concentration of dextrose (D-Glucose, 18 mM) present in ACD-PRPr resulted in reduction of endothelial proliferation and migration, delay of mouse skin regeneration and development of intradermal papules. Finally, collecting blood with half amount of SC significantly improved all the angiogenic and regenerative responses mediated by PRPr. In contrast, the delay of skin regeneration and the development of inflammatory papules remained stable after dilution of ACD. Conclusion Our findings indicate that (1) calcium restitution is required to impair the cellular and tissue alterations induced by citrated-anticoagulants contained in PRP; (2) ACD-derived dextrose confers anti-angiogenic, anti-regenerative and pro-inflammatory proprieties to PRP; and (3) half concentration of SC improves the angiogenesis and regeneration mediated by PRP.
Single-Cell Analysis of Neuroinflammatory Responses Following Intracranial Injection of G-Deleted Rabies Viruses

Viral vectors are essential tools for the study of neural circuits, with glycoprotein-deleted rabies viruses being widely used for monosynaptic retrograde tracing to map connectivity between specific cell types in the nervous system. However, the use of rabies virus is limited by the cytotoxicity and the inflammatory responses these viruses trigger. While components of the rabies virus genome contribute to its cytotoxic effects, the function of other neuronal and non-neuronal cells within the vicinity of the infected host neurons in either effecting or mitigating virally-induced tissue damage are still being elucidated. Here, we analyzed 60,212 single-cell RNA profiles to assess both global and cell-type-specific transcriptional responses in the mouse dorsal raphe nucleus (DRN) following intracranial injection of glycoprotein-deleted rabies viruses and axonal infection of dorsal raphe serotonergic neurons. Gene pathway analyses revealed a down-regulation of genes involved in metabolic processes and neurotransmission following infection. We also identified several transcriptionally diverse leukocyte populations that infiltrate the brain and are distinct from resident immune cells. Cell type-specific patterns of cytokine expression showed that antiviral responses were likely orchestrated by Type I and Type II interferon signaling from microglia and infiltrating CD4+ T cells, respectively. Additionally, we uncovered transcriptionally distinct states of microglia along an activation trajectory that may serve different functions, which range from surveillance to antigen presentation and cytokine secretion. Intercellular interactions inferred from transcriptional data suggest that CD4+ T cells facilitate microglial state transitions during the inflammatory response. Our study uncovers the heterogeneity of immune cells mediating neuroinflammatory responses and provides a critical evaluation of the compatibility between rabies-mediated connectivity mapping and single-cell transcriptional profiling. These findings provide additional insights into the distinct contributions of various cell types in mediating different facets of antiviral responses in the brain and will facilitate the design of strategies to circumvent immune responses to improve the efficacy of viral gene delivery.
Short chain fatty acid butyrate promotes virus infection by repressing interferon stimulated genes

Butyrate is an abundant metabolite produced by the gut microbiota and is known to modulate multiple immune system pathways and inflammatory diseases. However, studies of its effects on virus infection of cells are limited and enigmatic. We found that butyrate increases cellular infection and virus replication in influenza virus, reovirus, and human immunodeficiency virus infections. Further exploring this phenomenon, we found that addition of butyrate to cells deficient in type I interferon (IFN) signaling did not increase susceptibility to virus infection. Accordingly, we discovered that butyrate suppressed levels of specific IFN stimulated gene (ISG) products in human and mouse cells. Butyrate did not inhibit IFN-induced phosphorylation of transcription factors STAT1 and STAT2 or their translocation to the nucleus, indicating that IFN signaling was not disrupted. Rather, our data are suggestive of a role for inhibition of histone deacetylase activity by butyrate in limiting ISG induction. Global transcript analysis revealed that butyrate increases expression of more than 800 cellular genes, but represses IFN-induced expression of 60% of ISGs. Overall, we identify a new mechanism by which butyrate promotes virus infection via repression of ISGs. Our findings also add to the growing body of evidence showing that individual ISGs respond differently to type I IFN induction depending on the cellular environment, including the presence of butyrate. Importance Butyrate is a lipid produced by intestinal bacteria that can regulate inflammation throughout the body. Here we show for the first time that butyrate influences the innate antiviral immune response mediated by type I IFNs. A majority of antiviral genes induced by type I IFNs were repressed in the presence of butyrate, resulting in increased virus infection and replication in cells. This suggests that butyrate could be broadly used as a tool to increase growth of virus stocks for research and for the generation of vaccines. Our research also indicates that metabolites produced by the gut microbiome can have complex effects on cellular physiology as demonstrated by the dampening of an inflammatory innate immune pathway by butyrate resulting in a pro-viral cellular environment.
Assessing the Mental Health Status of Youth in Juvenile Justice Settings

Access OJJDP publications online at www.ojp. usdoj.gov/ojjdp with inadequate psychometrics, the failure to consider comorbidity (i.e., co-occurring conditions), problems with identifying sample characteristics, and a lack of information regarding when the assessments were conducted. They note that previous studies often did not define the timeframe for symptoms. However, distinguishing between lifetime and current symptoms is important not only for determining the prevalence of disorders but also in planning for immediate service needs.
Plant response to salinity: an analysis of ROS formation, signaling, and antioxidant defense

Reactive oxygen species (ROS) are byproducts of normal plant metabolism and their production is elevated under environmental stresses such as drought, extreme temperature, and salinity. Among these, salinity is a worldwide problem that impacts the fertility of arable lands and sustainability of food security, which is getting more attention due to climate change. Halophytes can survive and reproduce in soils containing high concentrations of salt and have developed adaptation mechanisms at physiological, biochemical, and molecular levels including maintenance of ROS metabolism. In this review, we aim to summarize findings related to ROS production, signaling, scavenging, and especially ROS avoidance mechanisms under salt stress. In addition, expressions of antioxidant genes in Arabidopsis thaliana and its close relative, the model halophyte Schrenkiella parvula, are compared. Moreover, time-course expression levels of genes encoding major antioxidant enzymes in the model plant A. thaliana are analyzed with publicly available data to understand rapid responses of antioxidant defense under salt stress. The role of ROS-Ca+2 interaction and involvement of NADPH oxidases in this process are also discussed in the context of the perception and signaling of salt stress.