Miracle-dz/UniFAR-FTUs huggingface dataset:
Pneumonic Plague Epidemic in Northeast China 1910–1911 and Dr. Wu Lien-Teh’s Great Contribution

From October 1910 to March 1911, the pneumonic plague, imported from natural foci on Mongolian and Transbaikal steppes, broke out in Northeast China. Based on a field visit, autopsy, bacteriological identification and close collaboration with local authorities and international colleagues, Dr. Wu Lien-Teh implemented a series of efficient anti-plague measures, which successfully controlled the development of extraordinary epidemic plaque. In his subsequent work, Dr. Wu proved the respiratory transmission of pneumonic plague and tarabagans’ role in the spread the same. The academic and cultural heritage of Dr. Wu is valuable treasures for medical progress in China.
Enhanced amyloid fibril formation of insulin in contact with catalytic hydrophobic surfaces

The important protein hormone insulin, responsible for different kind of functions in our body but mainly storage of nutrients, has for a long time been used for treatment of diabetic patients. This important protein is both physically and chemically unstable. Especially during production where the insulin protein is exposed to unnatural environmental conditions such as acidic pH has this been causing problems since huge volumes of the product go to waste.In the human body the environment for the protein is tolerable with normal body temperature and the right pH, but when the protein is commercially synthesised the environmental conditions are not ultimate. What happens during these unfavourable conditions is that the insulin starts to fibrillate. Meaning that linear, biologically inactive aggregates are formed. If then under these kinds of conditions such as high temperature and acidic pH, the insulin comes in contact with hydrophobic surfaces then the fibrillation of the protein goes even faster.In the following experiment I am going to investigate if the experiments and conclusions done before, where different kinds of additives to insulin solutions have been used to enhance the amyloid fibrillation of insulin, are as effective as it has been proposed and I am going to prove that the presence of hydrophobic surfaces, such as coated silicon surfaces or glass and addition of preformed fibrils, so called seeds, increase amyloid fibrillation of the insulin protein under certain conditions, in comparison with the normal fibrillation under the same conditions.
pint: Pairwise integration of functional genomics data

Multiple types of genomic observations from the same patients are increasingly available in biomedical studies, including measurements of geneand miRNA expression levels, gene copy number, and methylation status. By investigating the dependencies between these data sets it is possible to discover functional mechanisms and interactions that are not seen in the individual data sets. For example, integration of gene expression and copy number has been shown to reveal cancer-associated chromosomal regions and associated genes with potential diagnostic, prognostic and clinical impact [4]. We demonstrate how to integrate gene or micro-RNA expression with DNA copy number (aCGH) measurements to discover functionally active chromosomal aberrations. The models capture the shared signal in paired observations, and indicate the affected genes and patients. The methods are potentially applicable also to other types of biomedical data, including methylation, SNPs, alternative splicing and transcription factor binding, or in other application fields. The package provides general-purpose tools for the discovery and analysis of statistical dependencies between co-occurring data sources. The methods are based on a principled framework, probabilistic canonical correlation analysis [2] and its extensions [1, 3, 4]. Probabilistic formulation deals rigorously with uncertainty associated with small sample sizes common in biomedical studies, and the package also provides tools to guide dependency modeling through Bayesian priors [4].
Effects of amylose and resistant starch on starch digestibility of rice flours and starches

Amylose and resistant starch (RS) content in rice flours and starches were manipulated by adding high amylose and high RS maize starch. The maize starches were added to rice flours and rice starches at the levels of 10-50% w/w, resulting in the increase of amylose from approximately 30-56 and RS from 8 – 33 g/100 g dry sample. Physicochemical properties and starch digestibility of the mixtures, both flour and starch mixtures, were investigated. Differential scanning calorimetry (DSC) results showed that the addition of high amylose high RS maize starch at the levels in this study did not significantly (p > 0.05) alter gelatinization temperatures. Texture analysis as exhibited by hardness and adhesiveness of the mixture gels found inconsistent results. The key benefit of adding high amylose and high RS maize starch was that it can alter starch digestion rates and consequently lower estimated glycaemic indices (GIs) in both rice flour and starch mixtures.
Intraspecific Morphological Characteristics and Genetic Diversity of Korean Calanthe

The present study researched morphological characteristics and analyzed the genetic diversity by using RAPD in Calanthe species, native plant in Jeju, Korea. Twenty-six samples were selected by flower color, and 19 horticultural traits were investigated to study morphological characteristics. The C. discolor had the smallest leaf, the length and width of dorsal sepal, lateral sepal, petal, central lip, lateral lip, and flower stalk length were shortest and/or smallest except the spur and ovary length in Calanthe species, but those of Calanthe discolor for. sieboldii (Dence.) Ohwi (Calanthe discolor for. sieboldii) were the largest and/or biggest, and those of variants were the intermediate between C. discolor and C. discolor for. sieboldii, but spur length was the longest in C. discolor, the shortest in C. discolor for. sieboldii, and intermediate in the variants. Ovary length in C. discolor was shortest and C. discolor for. sieboldii and variants were similar with each other. The flower colors of C. discolor were brownish red, the value of CIE Lab was between 40 and 50. The flower color of C. discolor for. sieboldii was yellowish; the value of CIE Lab was between 110 and 130. And variants had various colors between 50 and 70 in the value of CIE Lab. After analyzing multiple band patterns of PCR products, 154 bands were selected as polymorphic RAPD markers. The analysis of Genetic distance of Calanthe species using RAPD showed that C. discolor and C. discolor for. sieboldii are more distant from each other than variants, and demonstrated the fact that genetic position of variants is between the other two species.
Paper Waste Recycle and Its Sludge Reduction - Towards Waste and Cost Minimization

Various biological treatments produce solid sludge, which needs to be treated further or disposed. The sludge can be incinerated, landfilled or can be used for various construction purposes. The domestic waste can be used for production of ethanol like products. Also various options like vermicomposting and anaerobic treatments are very useful. The methanol synthesis is added advantage of the anaerobic treatment. Aerobic treatments are also very common because of ease and acceptability. Paper waste is generally recycled. It can be recycled for limited number of cycles. Paper waste sludge can be used in concrete with better results. Also biofuel synthesis from the waste papers is reported. Production of ceiling boards, bioelectricity production, and fuel gas generation are some of the cost effective applications of waste papers.
Incremental View Maintenance with Triple Lock Factorization Benefits

We introduce F-IVM, a unified incremental view maintenance (IVM) approach for a variety of tasks, including gradient computation for learning linear regression models over joins, matrix chain multiplication, and factorized evaluation of conjunctive queries. F-IVM is a higher-order IVM algorithm that reduces the maintenance of the given task to the maintenance of a hierarchy of increasingly simpler views. The views are functions mapping keys, which are tuples of input data values, to payloads, which are elements from a task-specific ring. Whereas the computation over the keys is the same for all tasks, the computation over the payloads depends on the task. F-IVM achieves efficiency by factorizing the computation of the keys, payloads, and updates. We implemented F-IVM as an extension of DBToaster. We show in a range of scenarios that it can outperform classical first-order IVM, DBToaster's fully recursive higher-order IVM, and plain recomputation by orders of magnitude while using less memory.
Relativistic and Correlation Effects on the Lifetimes of 3s4p 3PJo Levels in Mg-like Sulphur and Chlorine

Accurate multiconfiguration Hartree-Fock calculations were performed to investigate the J-dependence of the lifetimes of 3s4p 3PJ0 (J = 2,1,0) in S V and Cl VI. The relativistic corrections have been included through the Breit-Pauli approximation. The variation with J, observed in S V but not in Cl VI [4], is explained by the selective opening of decay channels resulting from the triplet-singlet mixing and by the J-dependence found in the E1 spin-allowed transition decay rates where the coulomb and relativistic configuration interaction between 3s4p and 3p3d play a crucial role. The effects of the relativistic shift corrections on the wavefunction compositions and transition probabilities are discussed. New gf-values are reported for the singlet-singlet electric dipole transistions from 3s4p 1P10, taking into account the 1P-character loss due to the inter-symmetry mixing.
Personal Use of Technology at Work: Drivers and Effects on Professional Distraction

Despite the numerous benefits that Information Technology (IT) provides to its users, adverse effects from abusive use of personal devices in the workplace remains an unexplored subject. This research examines individual drivers of private use of Information Technologies at work and the relationship that Digital Distraction has as a significant component contributing to professionals’ loss of attention during their activities. Our results show that aspects associated with technological dependence are the main influences of personal Use of Technology at Work. Among these aspects, diminished Impulse Control is the most significant factor toward to the use of personal technologies compared to other factors. The research also reveals that digital distraction causes significant loss of professional concentration and that personal use of IT in the workplace is a direct effect of diminished professional engagement. Furthermore, the research reveals that personal use of applications that promote social interaction isn’t an escape for professionals who suffer weak Social Support from their peers in the workplace.
Antidiarrhoeal and antibacterial activity of aqueous and methanolic leaves extracts of Dissotis thollonii Cogn. (Melastomataceae)

ABSTRACT Objective To investigate the phytochemical test and selected pharmacological activities (antidiarrhoeal and antibacterial activity) of the aqueous and methanolic leaves extracts of Dissotis thollonii Cogn. (Melastomataceae) ( D. thollonii ). Methods The aqueous and methanolic extracts were evaluated for their antibacterial activities on the in vitro growth of 2 clinical isolates ( Staphylococcus aureus and Shigella flexneri ), and 5 reference bacteria strains [ Escherichia coli ATCC 8739 ( E. coli ), E. coli ATCC 10536, Salmonella typhi ATCC 6539, Enterobacter aerogenes ATCC 13048 and E. coli ATCC 11775] by determining the minimum inhibitory concentrations (MICs) and bactericidal concentrations using broth microdilution method as well as on the infectious, secretory and osmotic induced diarrhoea models in rats. Results The aqueous extract inhibited the in vitro growth of all bacteria tested (the 05 reference bacteria strains and the 02 clinical isolates), with MICs values comprised between 32 and 512 μg/mL, whereas the methanolic extract has done the same with the MICs values located between 128 and 512 μg/mL. In vivo , the methanolic and aqueous extracts provoqued at all doses, a significant decrease ( P D. thollonii had, after 6 h of observation, significantly ( P in vivo , diarrhoea induced experimentally by castor oil and magnesium sulphate, particularly by prolonging the latency time, reducing the water content of faeces, the frequency of defecation and the number of wet defecation as compared to the negative control which received distilled water and the animals having received 2.5 mg/kg of loperamide used as reference substance. The phytochemical assay revealed the presence of flavonoids, phenols and polyphenols in the leaves extracts of D. thollonii , which are compounds with antidiarrhoeal and antibacterial activities. Conclusions The leaves of D. thollonii thus have antibacterial and antidiarrhoeal effects, which could result from their activities on blocking the inhibiting effects of the bacterial enzymes, inhibiting the bacterial protein synthesis, allowing the rupture of the lipopolysaccharidic membrane, as well as on inhibiting prostaglandins-E 2 synthesis or increasing the hydroelectrolytic reabsorption. These results attestted the ethnopharmacological use of D. thollonii leaves in the treatment of diarrhoea and gastro-intestinal infections.
Genetic purity test of F1 hybrid Capsicum using molecular analysis

Summary A fast and accurate genetic purity test of F1 hybrid plants is essential for seed production and accelerating advanced breeding generations in breeding programmes. DNA technology has great potential for enhancing purity assessment of hybrids. Genetic purity of three F1 chili hybrids was determined using two molecular marker techniques RAPD and ISSR. RAPD analysis successfully detected all three F1 hybridity, while ISSR detected only two. This was due to the RAPD marker system producing a greater number of markers than the ISSR system.
The phylogenetic relationship of geographically separated "Flectonotus" (Anura: Hemiphractidae), as revealed by molecular, behavioral, and morphological data

Phylogenetic analyses of data derived from one mitochondrial gene and one nuclear gene show that the five species of small marsupial frogs currently recognized as Flectonotus are in fact two distinct and not closely related lineages. This conclusion is strongly supported by reproductive behavior and morphological characters. Thus, we recognize the genus Fritziana Mello-Leitao for the three species in southeastern Brazil and Flectonotus Miranda-Ribeiro for the two species in northern South America.
TREND ANALYSIS OF RAINFALL AND TEMPERATURE OVER SURAT DISTRICT OF GUJARAT STATE

Climate change is a major issue nowadays where whole of the country is suffering serious problem & of global warming. Precipitation and temperature are major climate parameters which affect the climate leading to the climate variability and climate change. In present study over Surat district of Gujarat state between the co-ordinates 21.1702 N, 72.8311 E, 21.0589 S and 72.79 W is carried out for 13 years (2001-2013) rainfall and temperature (minimum, maximum) trend analysis. Rank based non-parametric MannKendall (MK) test and Slope based Sen’s Slope (SS) test were performed in software XLSTAT 2016 to analyze trend. To detect the correlation between two variables Kendall’s tau method was used. Results of annual rainfall trend shows significant increasing trend over the study period while seasonal rainfall of southwest monsoon and post monsoon seasons shows insignificant increasing trend. Trends in annual maximum temperature shows significant decreasing trend while annual minimum temperature shows a significant increasing trend.
A Spatiotemporal Equilibrium Model of Migration and Housing Interlinkages

This paper develops and solves a spatiotemporal equilibrium model in which regional wages and house prices are determined jointly with location-to-location migration flows. The agent's optimal location choice and the resultant migration process is shown to be Markovian with the transition probabilities across all location pairs given as non-linear functions of wage and housing cost differentials, endogenously responding to migration flows. The model is calibrated on a panel of states in the U.S. mainland, and is shown to fit the data well. It is then used to analyze the size and speed of spatial spill-over effects by computing spatiotemporal impulse responses of positive productivity and land-supply shocks to California, as an example. It is shown that such a positive productivity shock raises local wages and induces net migration inflows from other states to California, and reduces population and house prices in other U.S. states. Not surprisingly, the responses of population and house prices tend to be stronger and quicker for the nearby states. The responses of U.S. states to a positive land-supply shock in California also have qualitatively the same spatiotemporal patterns. Similar results are obtained for other major U.S. states.
Production de terpènes fonctionnalisés par les cytochromes P450 de plantes recombinants

Notre objectif etait d’identifier des cytochromes P450 capables d’oxygener des mono et sesquiterpenes, pour produire des molecules aux proprietes organoleptiques interessantes labellises « naturelles » par l’industrie des aromes et du parfum.Nous avons identifie 7 couples P450-substrat catalysant une conversion in vitro superieure ≥ 45 % et/ou formant un produit attendu. Les quantites de produit obtenu par bioconversion dans la levure restent insuffisantes pour un procede industriel. Les facteurs limitants ont ete identifies dans le cas du valencene comme : 1) la toxicite induite par les produits, 2) l’accumulation du β-nootkatol dans les membranes, 3) l’inhibition de l’enzyme par les produits reactionnels. Trois cytochromes P450 d’Arabidopsis thaliana impliques dans le metabolisme indolique oxydent activement le limonene. Ils s’expriment dans les inflorescences et constituent le premier exemple de P450s suceptibles de participer a deux voies metaboliques independantes chez les plantes.
Resonant spin wave excitation in magnetoplasmonic bilayers by short laser pulses.

In magnetically ordered solids a static magnetic field can be generated by virtue of the transverse magneto-optical Kerr effect (TMOKE). Moreover, the latter was shown to be dramatically enhanced due to the optical excitation of surface plasmons in nanostructures with relatively small optical losses. In this paper we suggest a new method of resonant optical excitations in a prototypical bilayer composed of noble metal (Au) with grating and a ferromagnet thin film of yttrium iron garnet (YIG) via frequency comb. Based on magnetization dynamics simulations we show that for the frequency comb with the parameters, chosen in resonant with spin-wave excitations of YIG, TMOKE is drastically enhanced, hinting towards possible technological applications in the optical control of spintronics systems.
Effect of caries infiltration technique (icon) on the remineralization and color stability of enamel white spot lesions

This research was designed to evaluate the effect of resin infiltration material (Icon) and remineralizing agents (fluoride, CPP-ACP) on remineralization and color stability of enamel white spot lesion. A total number of 120 sound non-carious human anterior teeth were collected. The teeth were divided into two main groups (60 teeth each); Group R: for assessment of enamel remineralization and Group S: for assessment of color stability. Each main group was further divided into four equal subgroups (15 teeth each) according to the treatment applied as follows: Subgroup (A): control, Subgroup (P): CPP-ACP, Subgroup (I): ICON Subgroup (F): Fluoride. Each subgroup was further subdivided into three equal division (5 teeth each) according to the storage period in artificial saliva; one week (1W), four weeks (4W) and six weeks (6W). For assessment of remineralization; the enamel white spot lesion specimens in the four different subgroups were examined three times (after one week, four weeks and six weeks from the first time of treatment application) by (SEM/EDX). The results of remineralization revealed that the subgroup (P) group was provided the highest ca/p ratio mean value, followed by subgroup (F), then subgroup (I) while subgroup (A) showed the lowest ca/p ratio mean value. For assessment of color stability; the enamel white spot lesion specimens in the three different subgroups were examined three times (after one week, four weeks and six weeks from the first time of treatment application) by a portable Reflective spectrophotometer. The results of color stability revealed that the subgroup (F) was provided the highest color variation mean value, followed by subgroup (P) group while subgroup (I) showed the lowest color variation mean value.
Descripción de un modelo de infección in vitro con virus dengue empleando células mononucleares humanas de sangre periférica

Descripción de un modelo de infección in vitro con virus dengue empleando células mononucleares humanas de sangre periférica No existen modelos animales apropiados para el estudio de la fisiopatología y las manifestaciones clínicas de la enfermedad causada por la infección con virus dengue, por lo que para ello se requiere desarrollar modelos experimentales. El propósito del presente trabajo fue establecer un modelo de infección in vitro con virus dengue serotipo-2 (DENV-2). Para esto se obtuvieron células mononucleares de sangre periférica (CMSP) usando un gradiente de Ficoll, y se las cultivó e infectó con DENV-2 a una baja multiplicidad de infección. La subpoblación celular que se infectó y produjo citocinas se identificó empleando un análisis multiparamétrico por citometría de flujo. Como resultado, las CMSP fueron permisivas a la infección, que se detectó a las 24 horas de inoculado el virus. Además, en este mismo tiempo, los monocitos CD14+, pero no los linfocitos CD3+ o CD19+, fueron la subpoblación celular preferencialmente infectada y responsable de la producción de TNF-α e IL-6. En conclusión, se estableció un modelo de infección in vitro usando CMSP no fraccionadas, en el que se identificó a los monocitos CD14+ como la principal célula blanco de la infección con DENV-2 y productora de citocinas proinflamatorias.