Miracle-dz/UniFAR-FTUs huggingface dataset:
Sphingorhabdus soli sp. nov., isolated from Arctic soil.

A Gram-stain-negative, strictly aerobic, rod-shaped and non-motile bacterial strain, designated D-2Q-5-6T, was isolated from a soil sample collected from the Arctic region. Strain D-2Q-5-6T was found to grow at 10-43 °C (optimum, 28 °C), at pH 6.0-9.0 (pH 7.0) and in 0-5 % (w/v) NaCl (0-1 %). Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain D-2Q-5-6T fell into the genus Sphingorhabdus and shared less than 95.8 % identity with all type strains of recognized species of this genus. The major cellular fatty acids of strain D-2Q-5-6T were summed feature 8 (C18 : 1 ω7c and/or C18 : 1 ω6c; 31.4 %), summed feature 3 (C16 : 1 ω7c and/or C16 : 1 ω6c; 26.8 %) and C14 : 0 2OH (11.7 %). The polar lipids consisted of diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylcholine and sphingoglycolipid. The predominant quinone was identified as Q10. The DNA G+C content of strain D-2Q-5-6T was 64.5 mol%. Based on the results of phylogenetic analysis and distinctive phenotypic characteristics, strain D-2Q-5-6T is concluded to represent a novel species of the genus Sphingorhabdus, for which the name Sphingorhabdus soli sp. nov. is proposed. The type strain of the species is D-2Q-5-6T (=MCCC 1A06070T=KCTC 52311T).
High-Intensity Interval Training Shock Microcycle for Enhancing Sport Performance: A Brief Review.

Dolci, F, Kilding, AE, Chivers, P, Piggott, B, and Hart, NH. High-intensity interval training shock microcycle for enhancing sport performance: A brief review. J Strength Cond Res XX(X): 000-000, 2019-High-intensity interval training (HIIT) is a powerful strategy to develop athletes' fitness and enhance endurance performance. Traditional HIIT interventions involve multiple microcycles (7-10 days long) of 2-3 HIIT sessions each, which have been commonly supported to improve athletic performance after a minimum period of 6 weeks training. Regardless of the efficacy of such an approach, in recent years, a higher frequency of HIIT sessions within a unique microcycle, commonly referred to as an HIIT shock microcycle, has been proposed as an alternative HIIT periodization strategy to induce greater and more efficient endurance adaptation in athletes. This review article provides an insight into this new HIIT periodization strategy by discussing (1) HIIT shock microcycle format and design; (2) the sustainability of this training strategy; (3) effects on performance and physiological parameters of endurance; and (4) potential mechanisms for improvements. Evidence advocates the sustainability and effectiveness of HIIT shock microcycle in different athletes to improve intermittent and continuous running/cycling performance and suggests mitochondria biogenesis as the main acute physiological adaptation following this intervention.
Subcutaneous injection of recombinant heat shock protein 70 ameliorates atopic dermatitis skin lesions in a mouse model

Atopic dermatitis (AD) is a chronic inflammatory skin disease and sometimes is a tough challenge for physicians. We previously reported that in Th2 environment, the production and secretion of thymic stromal lymphopoietin (TSLP) from human keratinocytes was inhibited by recombinant heat shock protein 70 (rHSP70). The present study assessed the therapeutic effectiveness of rHSP70 in a mouse model of AD. An experimental model of AD was reproduced by systemic sensitization and local epicutaneous challenge with ovalbumin (OVA). Treatment of rHSP70 was performed by subcutaneous administration. The levels of OVA‐specific IgE, as well as cytokines, were detected by ELISA. Skin samples from patch areas were also taken for histologic examination. Injection of rHSP70 improved the histologic picture by reducing the thickness of epidermis and allergic inflammation. Skin sonography revealed rHSP70 ameliorated skin remodeling. rHSP70 also significantly decreased the protein expression of TSLP of skin from patch areas. Furthermore, in ex vivo studies also showed group of rHSP70 treatment decreased IL‐13, RANTES, MIP‐1β and increased IFN‐γ secreted from splenocytes stimulated with OVA. The rHSP70 intervention in the mouse model of AD reduced the skin expression of TSLP and attenuated the clinical appearance of OVA‐induced AD mice. The effect was achieved by suppressed Th2 immune response in injected skin tissue and enhanced systemic Th1 immune response. These results suggest that rHSP70 have potential as a promising protein for the treatment of AD.
The risk of fractures, acute myocardial infarction, atrial fibrillation and ventricular arrhythmia in geriatric patients exposed to promethazine

ABSTRACT Objectives: This study aimed to compare the risk of fractures, acute myocardial infarction, atrial fibrillation, and ventricular arrhythmia among Danish citizens aged ≥ 65 which were new users of promethazine or domperidone, triazolam, loratadine, and betahistine. Secondly, the study aimed to perform a risk stratification to identify the most relevant predictors for the study outcomes. Methods: The study period was 01/01/2015 to 31/12/2016. The data sources were the Danish registers. Each patient was followed for 90 days. A logistic regression model was used to compute the unadjusted and adjusted odds ratios (OR), and a conditional inference tree was used to identify the most relevant predictors for the study outcomes. Results: Promethazine had a higher risk of hospitalization for atrial fibrillation than loratadine and betahistine (OR 1.58; 95% CI 1.07–2.63 and OR 3.22; 95% CI 1.69–7.14, respectively). For fractures, acute myocardial infarction, and ventricular arrhythmia hospitalizations, no statistically significant differences were found among drugs under investigation. The medical history of cardiac arrhythmia (OR 4.14; 95% CI 2.94–5.78, p < 0.0001) was the most relevant predictor for atrial fibrillation hospitalizations. Conclusion: This study found an increased risk of atrial fibrillation hospitalization among promethazine users, and the risk was higher among patients with prior cardiac arrhythmia.
Phylogeny of Physarida (Amoebozoa, Myxogastria) Based on the Small‐Subunit Ribosomal RNA Gene, Redefinition of Physarum pusillum s. str. and Reinstatement of P. gravidum Morgan

Myxomycetes (also called Myxogastria or colloquially, slime molds) are worldwide occurring soil amoeboflagellates. Among Amoebozoa, they have the notable characteristic to form, during their life cycle, macroscopic fruiting bodies, that will ultimately release spores. Some 1,000 species have been described, based on the macroscopic and microscopic characteristics of their fruiting bodies. We were interested in Physarum pusillum (Berk. & M.A. Curtis) G. Lister, a very common species described with two variants, each bearing such morphological differences that they could represent two distinct species. In order to test this, we observed key characters in a large selection of specimens attributed to P. pusillum, to its synonyms (in particular Physarum gravidum), and to related species. In addition, the small‐subunit ribosomal RNA gene was obtained from seven of these specimens. Based on these data, we provide a comprehensive phylogeny of the order Physarida (Eukaryota: Amoebozoa: Conosa: Macromycetozoa: Fuscisporidia). Morphology and phylogeny together support the reinstatement of P. gravidum Morgan 1896 with a neotype here designated, distinct from P. pusillum, here redefined.
Characterization of Carotid Atherosclerotic Plaques Using 3-Dimensional MERGE Magnetic Resonance Imaging and Correlation With Stroke Risk Factors

Supplemental Digital Content is available in the text. Background and Purpose— High-resolution magnetic resonance imaging is capable of characterizing carotid atherosclerotic plaque morphology and composition. Most reported carotid plaque imaging techniques are 2-dimensional (2D) based with limited longitudinal coverage of ≈30 mm, which may be insufficient for complete visualization of extracranial carotid atheroma. A 3D black-blood imaging technique, motion-sensitized driven equilibrium prepared rapid gradient echo technique (3D-MERGE) can provide larger coverage. We sought to use 3D-MERGE to investigate carotid atherosclerosis plaque distribution and to analyze their correlation with clinical information and stroke risk factors. Methods— From 5 hospitals in China, 97 subjects suspected of recent stroke or transient ischemic attack were imaged with 3D-MERGE within 2 weeks of symptoms using 3T magnetic resonance imaging. Images were analyzed by 2 reviewers. Plaque length was calculated and categorized as plaques within, partially outside, or completely outside of typical 2D magnetic resonance imaging coverage. Associations between plaque features and clinical information, stroke risk factors were assessed. Results— Ninety-seven subjects with 194 carotid arteries (70 men and 27 women, mean age 60 years) were analyzed. Of the 136 plaques identified, 68 (50%) were within, 46 (33.8%) were partially outside, and 22 (16.2%) were completely outside of 2D magnetic resonance imaging coverage. Total plaque length was significantly positively associated with male sex (P<0.001), hypertension (P=0.011), and history of smoking (P<0.001). Hypertensive subjects were more likely to have at least one plaque completely outside the 2D magnetic resonance imaging coverage than nonhypertensive subjects (P=0.007). Conclusions— The 3D-MERGE allows for the identification of substantially more carotid plaques than 2D black-blood techniques. The extent and distribution of plaque, identified by the larger coverage afforded by 3D-MERGE, were found to correlate significantly with male sex and risk factors that are common among patients with stroke, including hypertension and history of cigarette smoking.
Self-assembled Biomimetic Nano-Matrix for Stem Cell Anchorage.

Mesenchymal stem cells (MSCs) have been widely applied in biomedicine due to their ability to differentiate into many different cell types and their ability to synthesize a broad spectrum of growth factors and cytokines that directly and indirectly influence other cells in their vicinity. To guide MSC infiltration to a bone fracture site, we developed a novel self-assembled Nano-Matrix which can be used as an injectable scaffold to repair bone fractures. The Nano-Matrix is formed by Janus base nanotubes (JBNTs) and fibronectin (FN). JBNTs are nucleobase-derived nanotubes mimicking collagen fibers, and FN is one of the cell adhesive glycoproteins which is responsible for cell-extracellular matrix interactions and guides stem cell migration and differentiation to desired cells types. Here, we demonstrated the successful fabrication and characterization of the JBNT/FN Nano-Matrix as well as its excellent bioactivity that encouraged human MSC migration and adhesion. This work lays a solid foundation for using the Nano-Matrix as an injectable approach to improve MSC retention and function during bone fracture healing.
Susceptibility to capillary plugging can predict brain region specific vessel loss with aging

Vessel loss in the aging brain is commonly reported, yet important questions remain concerning whether there are regional vulnerabilities and what mechanisms could account for these regional differences, if they exist. Here we imaged and quantified vessel length, tortuosity and width in 15 brain regions in young adult and aged mice. Our data indicate that vessel loss was most pronounced in white matter followed by cortical, then subcortical grey matter regions, while some regions (visual cortex, amygdala, thalamus) showed no decline with aging. Regions supplied by the anterior cerebral artery were more vulnerable to loss than those supplied by middle or posterior cerebral arteries. Vessel width and tortuosity generally increased with age but neither reliably predicted regional vessel loss. Since capillaries are naturally prone to plugging and prolonged obstructions often lead to vessel pruning, we hypothesized that regional susceptibilities to plugging could help predict vessel loss. By mapping the distribution of microsphere-induced capillary obstructions, we discovered that regions with a higher density of persistent obstructions were more likely to show vessel loss with aging and vice versa. These findings indicate that age-related vessel loss is region specific and can be explained, at least partially, by regional susceptibilities to capillary plugging.
Identifying the optimum first-line therapy in BRAF-mutant metastatic melanoma

ABSTRACT Introduction: The emergence of molecularly targeted agents and immune checkpoint inhibitors has positively revolutionized the management and prognosis of BRAF-mutant metastatic melanoma. However, the availability of both therapeutic options, with their pros and cons, rationally triggered clinical considerations for the optimum frontline and subsequent treatment decisions. Areas covered: Here, we debate all approved therapies in patients with BRAF-mutant metastatic melanoma evaluating their efficacy and safety based on their pivotal trials. With prospective randomized data pending, retrospective comparisons of BRAF/MEK versus immune checkpoint inhibitors are reviewed to recognize any advantage between these two alternatives and to optimize their implementation. Preclinical and early clinical results of combining concurrently or sequentially targeted therapy and immunotherapy are also discussed. Expert opinion: BRAF/MEK inhibitors produce rapid and deep responses and should be included in first-line approaches, particularly in cases with aggressive and bulky disease, while single or double checkpoint inhibition lead to more durable responses and could be involved either in frontline treatment of BRAF-mutant melanoma with less unfavorable characteristics or in maintenance after initial targeted induction or in future immune/targeted regimens for high-risk groups. Data from ongoing trials directly comparing or combining these strategies are expected to update their role in a more individualized basis.
Less imitation of arbitrary actions is a specific developmental precursor to callous-unemotional traits in early childhood.

OBJECTIVE Callous-unemotional (CU) traits in early childhood explain heterogeneity within conduct problems and are associated with higher risk for later diagnoses of childhood disruptive behavior disorders and antisocial behavior in adulthood. Emerging research implicates impairments in affiliative processes in the etiology of CU traits. The current study tests whether the imitation of intentional actions with no functional significance -a behavior that supports the acquisition of social conventions and affiliative bonds, is a specific developmental precursor to CU traits in early childhood. METHODS Data came from a longitudinal twin study of 628 children (Age 2: 47% females; Age 3: 44.9% females) with observations of arbitrary (i.e., nonfunctional actions) and instrumental (i.e., functional actions) imitation and parent reports of CU traits and oppositional defiant (ODD) behaviors at ages 2 and 3. RESULTS Lower arbitrary imitation at age 2, but not instrumental imitation, was related to increases in CU traits from ages 2 to 3 (β = -.10, p = .02). CONCLUSIONS These findings establish early social and affiliative processes in the etiology of CU traits, highlighting that novel personalized treatment and intervention strategies for CU traits may benefit from targeting these processes to help reduce CU traits and risk for persistent conduct problems in children.
Depression and Anxiety Moderate the Relationship Between Body Image and Personal Well-being Among Patients With an Implanted Left Ventricular Assist Device.

BACKGROUND Left ventricular assist devices (LVADs) support the diseased heart of patients with advanced heart failure and are used as a bridge to heart transplantation or as destination therapy for patients ineligible for heart transplantation. Body image changes, as well as anxiety and depression, are prevalent among patients with an implanted LVAD. OBJECTIVE The aim of this study was to investigate whether a relationship exists between body image and personal well-being among patients with an implanted LVAD and, if it does, whether it is moderated by anxiety and depression. METHODS In this cross-sectional correlational study, a convenience sample of 30 adult patients with an implanted LVAD (mean age, 63 ± 10; 90% male) from the outpatient facility of a tertiary medical center completed validated instruments including the Body Image Scale, Cosmetic Scale, Hospital Anxiety and Depression Scale, and Personal Well-being Index, from October 2017 to February 2018. Results were subjected to multivariate linear regression and bootstrap moderation analyses. RESULTS Eleven patients (37%) had below-average personal well-being scores, and 14 patients (47%) had below-average body image scores. Seven (23%) had either anxiety or depression, and 11 (37%) had both anxiety and depression. Body image was found to be a significant predictor of personal well-being (t = 2.16, P = .04). When anxiety and depression were present, body image (t = 2.08, P = .049), depression (t = 2.53, P = .018), and the interaction between body image and depression (t = -2.1, P = .047) were significantly associated with personal well-being. CONCLUSIONS Body image significantly predicted personal well-being among patients with an implanted LVAD. Depression alone, or depression combined with anxiety, moderated the relationships between body image and personal well-being. The current results may help to heighten healthcare providers' awareness of body image perception among patients with an implanted LVAD.
Does social comparison affect immigrants’ subjective well-being?

Despite the growing number of papers which concentrate on economic and social integration of immigrants across Europe, just a few analyze their subjective wellbeing. In this paper, we focus on immigrant's life satisfaction and concentrate – for the first time in the European context – on how the social comparison with two reference groups (natives and other immigrants) within the host country may affect immigrant's life satisfaction. Using data from six rounds of the European Social Survey, we proxied the level of “social comparison” by constructing two measures of economic distance that compare each immigrant with the average of the group of natives and the group of immigrants with the same characteristics. Preliminary results indicate that as the disadvantage between the immigrant and the average value of each of the two reference groups becomes smaller (or, eventually, becomes advantage), immigrant's life satisfaction increases. The effect of the social comparison with natives appears larger than the social comparison with immigrants and, in both cases it is stronger for individuals with higher level of education.
Title: Interval Estimation of Variance Ratio in Non- Normal Unbalanced One-Way Random Models Author(s):

Confidence intervals based on the harmonic mean method are proposed for estimating the ratio of variance components and/or the intraclass correlation coefficient (ρ) in unbalanced one-way random models without the normality assumptions. Since the proposed procedure is heavily dependent on the estimation of the kurtosis of the underlying distributions, bias-corrected estimators of kurtosis are proposed as well. Several asymptotic results concerning the proposed procedure are given along with simulation results to assess its performance in finite sample size situations. The proposed intervals are also compared with the corresponding confidence intervals based on the arithmetic mean method and were found to effectively maintain the nominal probability of coverage, except for leptokurtic distributions with fairly large kurtosis where the intervals tend to be liberal. According to the simulation results, the proposed harmonic mean intervals are recommended for use in practice. However, while computing the harmonic mean intervals, the bias-corrected estimators of kurtosis should be used when it is anticipated that ρ is small, but for large ρ the empirically corrected estimators of kurtosis should be adopted. The procedure is illustrated using a real data set.
Orientation Determination for Android Smartphones

Many Virtual Reality, Augmented Reality, gesture based applications or games on smartphones or tablets require the tracking of the orientation of the device. This is achieved by using built-in sensors such as accelerometer, compass and gyrometer. By using sensor fusion algorithms the accumulated errors of individual sensors can be corrected and the tracking quality can be improved. We propose an algorithm and a multithreaded architecture for Android smartphones that interpolates between the orientation gained from accelerometer and compass and the rotation gained from the gyrometer. Rotations are presented using quaternions. We illustrate the solution with a simple 3D simulation. We compare our solution with the Android built-in virtual rotation sensor.
A Malinchismo Scale for Use among Adolescents

Malinchismo is a recently documented concept referring to preferencing the culture, ideas, tastes and behaviors of another nation/culture over one’s own. First, we introduce this new concept in relation to post-colonial theory, social identity theory, and remote acculturation theory, explaining its relevance to adolescent development. We then introduce and validate a new Malinchismo scale using a derivative sequential method among two samples of adolescents in Mexico (n = 560 total). Our Malinchismo Scale is more comprehensive than existing alternatives and is the first to be validated for use among adolescents. We assessed 1) content validity using the responses of content experts who served as judges, 2) construct validity using exploratory and confirmatory factor analyses (EFA and CFA, respectively), and 3) convergent and discriminant validity using participant responses to the Ingroup Interethnic Bias Test. In total, 366 adolescents were in the EFA sample (M=16.18 years, SD=0.74, 62% female) and 194 adolescents were in the CFA sample (M=16.17, SD=1.06, 57% female). Results revealed excellent psychometric properties on all indices, supporting the Malinchismo Scale as a valid and reliable measure for adolescents.
Decomposing the Immeasurable Sport: A deep learning expected possession value framework for soccer

What is the right way to think about analytics in soccer? Is the sport about measured events such as passes and goals, possession percentages and traveled distance, or even more abstract notions such as mistakes (to quote Cruyff, “Soccer is a game of mistakes, whoever makes the fewer wins”)? Analytical work to date has focused primarily on these more isolated aspects of the sport, while coaches tend to focus on the tactical interplay of all 22 players on the pitch. Soccer analytics is lacking from a comprehensive approach that can start to address performance-related questions that are closer to the language of the game. Questions such as: who adds more value? How and where is this value added? Are the teammates creating spaces of value? When and how should a backward pass be taken? How risky is a team attacking strategy? What is a player’s decisionmaking profile?