Miracle-dz/UniFAR-FTUs huggingface dataset:
The Association Between Glycemic Variability and Macronutrients in Young Children with T1D.

OBJECTIVE There is limited information regarding the potential effect macronutrients have on postprandial glycemic variability in young children with type 1 diabetes (T1D). To date, studies examining nutrition and glycemic outcomes either assess these factors at a single timepoint, or aggregate large datasets for group level analyses. This study examined how inter- and intraindividual fluctuations in carbohydrate, fat, and protein intake impact glycemic variability in the postprandial period for young children with T1D. METHODS Thirty-nine young children, aged 2-6 years, wore a continuous glucose monitor for 72 hr, while their parents completed detailed diet records of all food intake. The analyses tested three multilevel models to examine intra- and interindividual differences between food intake and postprandial glycemic variability. RESULTS The results suggest carbohydrate intake, relates to greater postprandial glycemic variability. In contrast, the results reveal the inverse effect for protein, suggesting a tendency for young children who ate more protein at some meals to have lower postprandial glycemic variability, with the exception of lunch. There was no effect for fat on postprandial glycemic variability. CONCLUSION These results suggest protein consumption may be an important consideration when aiming for optimal glycemic levels for some meals. When counseling parents of young children with T1D on common behaviors underlying glycemic excursion, pediatric psychologists may consider discussing the nutritional make up of children's meals. Further, the results demonstrate retaining longitudinal data at the person level, versus aggregating individual data for group level analyses, may offer new information regarding macronutrient intake and glycemic outcomes.
Interaction Among Deer in a Chronic Wasting Disease Endemic Zone

ABSTRACT Although it is known that chronic wasting disease (CWD) can be transmitted by both direct animal-to-animal contact and contact with contaminated environments, the relative role of each mechanism in the spread of CWD in free-ranging populations has yet to be defined. We investigated patterns of interaction between mule deer (Odocoileus hemionus) in order to understand how factors such as season and landscape may influence patterns of disease spread in these populations. Using location data from male and female Global Positioning System (GPS)-collared mule deer in 5 study areas located in and around a CWD-endemic zone in southern Saskatchewan, Canada, we quantified close proximity events, or events involving both spatial and temporal overlap of individuals. We defined close proximity events as occurrences in which 2 deer were located <25 m apart at the same point in time. We looked at seasonal variation in the probability of close proximity events, as well as landscape factors associated with these events when compared to areas of shared space use, or spatial overlap alone. Overall probability of an individual GPS-collared deer being located in close proximity to another GPS-collared deer was 0.092 (n = 107). The early gestation (16 Dec– 31 Mar) and late gestation (1 Apr–15 May) seasons had the highest probability of close proximity events occurring, and same-sex pairs were more likely to be found in close proximity than between-sex pairs during all seasons aside from the rut (1 Nov–15 Dec). High probability of close proximity events during the gestation seasons agrees with the tendency of mule deer to aggregate into large groups during late winter and suggests that this may be an important time period for CWD transmission to occur. Close proximity events occurred more in cropland and wetland than expected based on availability, whereas close proximity events occurred less than expected in grassland. The opposite was true for spatial overlap between individuals, which occurred more than expected in areas of low elevation and rugged terrain and in grassland or shrub-wood habitats. These results suggest that cropland may be a higher risk habitat for direct and indirect CWD transmission between individuals and that, although coulees and other areas of rugged topography are less likely to be associated with close proximity events, those areas may be more likely to contain environmental contamination in CWD-affected areas due to common use by multiple deer.
A Development-Associated Decrease in Osmotic Potential Contributes to Fruit Ripening Initiation in Strawberry (Fragaria ananassa)

Fruit development and ripening are accompanied by a large increase in cellular soluble solid contents, which results in a significant decrease in osmotic potential (DOP). Here, we report that this development-associated DOP contributes to the initiation of ripening in strawberry (Fragaria ananassa Duch., Benihoppe) fruit. We show that fruit water potential significantly decreases at the onset of ripening as a result of the DOP. Further analysis using nuclear magnetic resonance spectroscopy (NMR) indicated that the change in fruit water potential was likely caused by catabolism of large molecules in receptacle cells, and bioinformatic analysis identified a family of osmotin-like proteins (OLP) that have a potential role in osmolyte accommodation. The gene expression of more than half of the OLP members increased substantially at the onset of fruit ripening, and specifically responded to DOP treatment, consistent with a close relationship between DOP and fruit ripening. We report that the DOP induced either by mannitol or water loss, triggered fruit ripening, as indicated by the elevated expression of multiple ripening genes and diverse ripening-associated physiological parameters. Collectively, these results suggest that the DOP contributes to strawberry fruit ripening initiation.
Salmon carcasses influence genetic linkages between forests and streams

Biodiversity at many scales (functional group, species, genetic) can result in emergent ecological patterns. Here we explore the influence of tree genotypic variation and diversity on in-stream ecosystem processes and aquatic communities. We test whether genetically diverse inputs of leaf litter interact with a keystone organism, anadromous salmon, to influence in-stream ecosystem function. We used reach-level manipulation of salmon carcasses and leaf litter bags to examine how nutrient inputs interact with genetic variation in leaf litter decomposition. Genotypic variation in black cottonwood (Populus balsamifera ssp. trichocarpa) significantly influenced leaf litter chemistry, litter mass loss, and fungal biomass, but these variables were only weakly influenced by salmon carcass presence or a genotype × salmon (G × E) interaction. Mixtures of genotypes tended to demonstrate antagonistic effects (slower than expected decomposition) in the absence of salmon, but synergistic effects (faster than expected d.
Anonymity Effects: A Large-Scale Dataset from an Anonymous Social Media Platform

Today online social media sites function as the medium of expression for billions of users. As a result, aside from conventional social media sites like Facebook and Twitter, platform designers introduced many alternative social media platforms (e.g., 4chan, Whisper, Snapchat, Mastodon) to serve specific userbases. Among these platforms, anonymous social media sites like Whisper and 4chan hold a special place for researchers. Unlike conventional social media sites, posts on anonymous social media sites are not associated with persistent user identities or profiles. Thus, these anonymous social media sites can provide an extremely interesting data-driven lens into the effects of anonymity on online user behavior. However, to the best of our knowledge, currently there are no publicly available datasets to facilitate research efforts on these anonymity effects. To that end, in this paper, we aim to publicly release the first ever large-scale dataset from Whisper, a large anonymous online social media platform. Specifically, our dataset contains 89.8 Million Whisper posts (called "whispers'') published between a 2-year period from June 6, 2014 to June 6, 2016 (when Whisper was quite popular). Each of these whispers contained both post text and associated metadata. The metadata contains information like coarse-grained location of upload and categories of whispers. We also present preliminary descriptive statistics to demonstrate a significant language and categorical diversity in our dataset. We leverage previous work as well as novel analysis to demonstrate that the whispers contain personal emotions and opinions (likely facilitated by a disinhibition complex due to anonymity). Consequently, we envision that our dataset will facilitate novel research ranging from understanding online aggression to detect depression within online populace.
Propensity score specification for optimal estimation of average treatment effect with binary response

Propensity score methods are commonly used in statistical analyses of observational data to reduce the impact of confounding bias in estimations of average treatment effect. While the propensity score is defined as the conditional probability of a subject being in the treatment group given that subject’s covariates, the most precise estimation of average treatment effect results from specifying the propensity score as a function of true confounders and predictors only. This property has been demonstrated via simulation in multiple prior research articles. However, we have seen no theoretical explanation as to why this should be so. This paper provides that theoretical proof. Furthermore, this paper presents a method for performing the necessary variable selection by means of elastic net regression, and then estimating the propensity scores so as to obtain optimal estimates of average treatment effect. The proposed method is compared against two other recently introduced methods, outcome-adaptive lasso and covariate balancing propensity score. Extensive simulation analyses are employed to determine the circumstances under which each method appears most effective. We applied the proposed methods to examine the effect of pre-cardiac surgery coagulation indicator on mortality based on a linked dataset from a retrospective review of 1390 patient medical records at Jewish Hospital (Louisville, KY) with the Society of Thoracic Surgeons database.
Sexual Coercion Among University Female Students in South-South Nigeria

This study investigated sexual coercion among university female students in South-South, Nigeria. The influence of age and parent living conditions on the university female students experience of sexual coercion where also investigated. Sexual coercion is the dependent variable while age and parents living conditions are the independent variables. The study employed the descriptive research of the survey type. The population is the university student South-South Nigeria. The sample is 1,200 university students selected from nine universities drawn from the south-south using stratified sampling technique. A research instrument titled sexual coercion questionnaire (SCQ) was used. One research question and two hypotheses guided the study. Frequency counts and percentages were used to ensure the general question while t-test was used for the two hypotheses generated. The results show that most forms of sexual coercion exist among female students. Moreover, age and parents living conditions will not significantly influence their experience of sexual coercion. University female students should be careful of dealings with the opposite sex. Those female students with wealthy parents should be careful of their spending on boys while those with poor parents should be patient. Counsellors should advocate for more security in the South-South Nigeria University to arrest maladjustment behavior among students, counselors also should organize skill acquisition program for the benefits of the female students. Government should provide well secured accommodation for the students.
Systemic and heart autonomous effects of sphingosine Δ4 desaturase deficiency in lipotoxic cardiac pathophysiology

ABSTRACT Lipotoxic cardiomyopathy (LCM) is characterized by cardiac steatosis, including the accumulation of fatty acids, triglycerides and ceramides. Model systems have shown the inhibition of ceramide biosynthesis to antagonize obesity and improve insulin sensitivity. Sphingosine Δ4 desaturase (encoded by ifc in Drosophila melanogaster) enzymatically converts dihydroceramide into ceramide. Here, we examine ifc mutants to study the effects of desaturase deficiency on cardiac function in Drosophila. Interestingly, ifc mutants exhibited classic hallmarks of LCM: cardiac chamber dilation, contractile defects and loss of fractional shortening. This outcome was phenocopied in global ifc RNAi-mediated knockdown flies. Surprisingly, cardiac-specific ifc knockdown flies exhibited cardiac chamber restriction with no contractile defects, suggesting heart autonomous and systemic roles for ifc activity in cardiac function. Next, we demonstrated that ifc mutants exhibit suppressed Sphingosine kinase 1 (Sk1) expression. Ectopic overexpression of Sk1 was sufficient to prevent cardiac chamber dilation and loss of fractional shortening in ifc mutants. Partial rescue was also observed with cardiac- and fat-body-specific Sk1 overexpression. Finally, we showed that cardiac-specific expression of Drosophila inhibitor of apoptosis (dIAP) also prevented cardiac dysfunction in ifc mutants, suggesting a role for caspase activity in the observed cardiac pathology. Collectively, we show that spatial regulation of sphingosine Δ4 desaturase activity differentially affects cardiac function in heart autonomous and systemic mechanisms through tissue interplay. Summary: Systemic versus heart autonomous functions of sphingosine Δ4 desaturase differentially regulate cardiac structure and function in a tissue-specific manner in Drosophila, where organ interplay mimics that observed in mammalian systems.
Nostalgic Tourism

This article presents exploratory research that focuses on a segment of cultural consumers who possess a yearning to connect with their ancestry. The article presents a conceptual framework to better understand the market segments within the cultural tourism industry and argues for the need to better understand and study the segment of consumers who rely on tours to search for their own ancestral roots. A multimethod study conducted over the course of a 23‐day bus tour is presented. Observational, interview, and survey data gathered from tourists of British and Irish descent are used to test the proposed relationships.
Regulation of Flavonoid Biosynthetic Genes in Germinating

Many higher plants, including Arabidopsis, transiently display purple anthocyanin pigments just after seed germination. We observed that steady state levels of mRNAs encoded by four flavonoid biosynthetic genes, PAL7 (encoding phenylalanine ammonia-lyase l), CHS (encoding chalcone synthase), CHI (encoding chalcone isomerase), and DFR (encoding dihydroflavonol reductase), were temporally regulated, peaking in 3-day-old seedlings grown in continuous white light. Except for the case of PAL7 mRNA, mRNA levels for these flavonoid genes were very low in seedlings grown in darkness. Light induction studies using seedlings grown in darkness showed that PALI mRNA began to accumulate before CHS and CHI mRNAs, which, in turn, began to accumulate before DFR mRNA. This order of induction is the same as the order of the biosynthetic steps in flavonoid biosynthesis. Our results suggest that the flavonoid biosynthetic pathway is coordinately regulated by a developmental timing mechanism during germination. Blue light and UVB light induction experiments using red lightand dark-grown seedlings showed that the flavonoid biosynthetic genes are induced most effectively by UVB light and that blue light induction is mediated by a specific blue light receptor.
Leaf Litter Decomposition and Invertebrate Colonization in Alpine Environments Above the Tree Line: an Experimental Study

ABSTRACT: Recent studies suggested a general warming trend in the Alps, resulting in a significant migration of forests to altitudes higher than the usual, regional tree line. As a consequence, some headwater streams will likely receive more allochthonous organic matter. For this reason, the dynamics of decomposition of terrestrial leaf detritus in stream reaches that naturally lacked this resource represents a subject of considerable interest, on which no information is currently available. The aim of this study was to analyse breakdown and macroinvertebrate colonisation of leaf bags in an Alpine headwater stream above the tree line. Results of this study indicate that decomposition of terrestrial leaves in a lotic alpine environment above the tree line takes place through a process similar to what happens at lower altitudes, but with some differences. The reduced rate of decomposition observed may be due to lower temperatures. At lower altitudes, tree cover provides a supply of organic material sufficient to support a rich guild of shredders. This study demonstrates that also above tree line, where communities are dominated by scrapers, an important part of the benthic community take part in the decomposition process of leaves. We can conclude that streams above the tree line, while hosting invertebrate communities dominated by rhithrophilous organisms that feed mostly on biofilm, also harbour a rich population of opportunist invertebrates. It seems that, in the case of expected temperature increase at higher altitudes , terrestrial organic detritus may be actively degraded by lotic benthic communities.
Quantitative trait loci and candidate genes for the economic traits in meat-type chicken

Recent progress has been achieved in the identification of quantitative trait loci (QTLs) and candidate genes, and they have been found to be very important for the production of chickens with more desirable meat characteristics. The major economic traits of chicken meat production were divided into two major categories, namely growth and carcass condition. In this paper, the QTL locations and candidate genes for the above mentioned traits are reviewed. The results presented here will provide guidelines for the selection of high quality and highly productive chickens through the marker assisted selection (MAS), which should be extensively used by poultry breeders and companies.
TWO-GENERATION REPRODUCTION STUDY BY DOSING WITH GLUTARALDEHYDE IN THE DRINKING WATER OF CD RATS

Adult male and female CD rats (F0) were dosed with glutaraldehyde (GA; CAS number 111-30-8) in drinking water at concentrations of 0 (controls), 50, 250, or 1000 ppm for a 10-wk prebreed period and through mating, gestation, and lactation. Resultant Fl offspring, selected to be parents of the next generation, were continued on the same regime from prebreed through lactation. Twenty-eight parental animals per sex per generation for each dose group were evaluated for clinical signs, body weight (absolute and gain), and water and food consumption. The offspring were evaluated for survival and body weight to weaning. Necropsy and light microscopic examination of removed tissues were conducted in all F0 and F1
Spatial heterogeneity increases the importance of species richness for an ecosystem process

The role of biodiversity in mediating ecosystem processes has been the subject of focused theoretical and empirical attention since the mid-1990s. Theory predicts that the balance between species richness and identity effects will critically depend on the degree of environmental heterogeneity, which dictates the extent to which differences between species in patterns of resource use can be expressed. We conducted a mesocosm experiment to explicitly test this hypothesis. We manipulated the richness and identity of intertidal molluscan grazers, as well as the spatial heterogeneity of the substrate upon which they grazed. The magnitude of algal consumption was used as our focal ecosystem process. The grazer treatments consisted of three monocultures and a single polyculture including all three species; heterogeneity was represented as the proportion of topographically complex and flat substrate. Species identity had strong effects on homogeneous substrates, with the identity of the best-performing species dependent on the substrate. On the heterogeneous substrate, suitable conditions for all three species were represented, allowing the expression of spatial complementarity of resource use and the enhancement of total algal consumption. Our findings provide the first explicit experimental evidence that spatial heterogeneity of the physical environment can play a key role in mediating effects of species diversity.
Application layer scheduling in cloud: ?fundamentals, review and research directions

The cloud computing paradigm facilitates a finite pool of on-demand virtualized resources on a pay-per-use basis. For large-scale heterogeneous distributed systems like a cloud, scheduling is an essential component of resource management at the application layer as well as at the virtualization layer in order to deliver the optimal Quality of Services (QoS). The cloud scheduling, in general, is an NP-hard problem due to large solution space, thus, it is difficult to find an optimal solution within a reasonable time. In application layer scheduling, the tasks are mapped to logical resources (i.e., virtual machines), aiming to optimize one or more QoS parameters, and conforming to several constraints. Various algorithms have been proposed in the literature for application layer scheduling, where each of them is based on some fundamental design techniques like simple heuristics, meta-heuristics, and most recently hybrid heuristics. Although ample literature survey exists for cloud scheduling algorithms, none of them present their study exclusively for the application layer. In this survey paper, we present a study on task scheduling algorithms used only at the application layer of the cloud. We classify our study according to various fundamental techniques used in designing such scheduling algorithms. One of the main features of our study is that it covers numerous application type e.g., a set of independent tasks, simple workflow, scientific workflow, and MapReduce jobs. We also provide a comparative analysis of existing algorithms on various parameters like makespan, cost, resource utilization, etc. In the end, research directions for future work have been provided