Miracle-dz/UniFAR-FTUs huggingface dataset:
Chemical composition, carbohydrate digestibility, and antioxidant capacity of cooked black bean, chickpea, and lentil Mexican varieties Composición química, digestibilidad de carbohidratos, y capacidad antioxidante de variedades mexicanas cocidas de frijol negro, garbanzo, y lenteja

The consumption of legume seeds in developing countries is very important because of their low cost and valuable nutritional characteristics (high protein, digestible and indigestible carbohydrates, and polyphenols content). However, limited information is available on the indigestible carbohydrates and the antioxidant capacity of legumes growing in Mexico. The cooked seeds of three Mexican pulses (black bean, chickpea, and lentil) were evaluated regarding their chemical composition, in vitro starch digestibility, polyphenols content and antioxidant capacity. The highest protein contents were recorded in chickpeas and lentils with no difference between them. Black bean presented the highest dietary fiber, resistant starch, and total indigestible fraction contents. The highest polyphenols and anthocyanins contents were shown by lentil and black bean, respectively. However, black bean exhibited the highest antioxidant capacity, which suggess an important role for anthocyanins in this effect. Present data confirm these legumes as a good source of indigestible carbohydrates and natural antioxidants; their consumption might have a role in preventing diabetes and other chronic-degenerative diseases.
Predicting volumes by log grades in standing sugar maple and yellow birch trees in southern Quebec, Canada

Modelling volumes by log grades in standing hardwood trees is often hindered by the nature of the response variable. In this paper, we used a two-part conditional model to account for the excess of zero responses for some log grades. Moreover, this approach was used as a framework to compare three different tree classifications in their ability to predict volumes by log grades in standing yellow birch (Betula alleghaniensis Britton) and sugar maple (Acer saccharum Marsh.) trees. A tree grade classification was compared with two preharvest tree classifications based on mortality risk as- sessment. A cross-validation was also carried out to evaluate the two parts of the model. The results showed that the two- part conditional approach was efficient in this case study. Compared with a general model, the three classifications im- proved the maximum likelihood. According to the Akaike and Bayesian information criteria, the tree grade classification was the ''best'' one. All three classifications proved to be better able to distinguish log grade occurrence than log grade volume. Although it implies additional cost, the implementation of the tree grade classification into the preharvest invento- ries would improve the prediction of volumes by log grades for yellow birch and sugar maple trees.
Deep Attentive Video Summarization With Distribution Consistency Learning

This article studies supervised video summarization by formulating it into a sequence-to-sequence learning framework, in which the input and output are sequences of original video frames and their predicted importance scores, respectively. Two critical issues are addressed in this article: short-term contextual attention insufficiency and distribution inconsistency. The former lies in the insufficiency of capturing the short-term contextual attention information within the video sequence itself since the existing approaches focus a lot on the long-term encoder–decoder attention. The latter refers to the distributions of predicted importance score sequence and the ground-truth sequence is inconsistent, which may lead to a suboptimal solution. To better mitigate the first issue, we incorporate a self-attention mechanism in the encoder to highlight the important keyframes in a short-term context. The proposed approach alongside the encoder–decoder attention constitutes our deep attentive models for video summarization. For the second one, we propose a distribution consistency learning method by employing a simple yet effective regularization loss term, which seeks a consistent distribution for the two sequences. Our final approach is dubbed as Attentive and Distribution consistent video Summarization (ADSum). Extensive experiments on benchmark data sets demonstrate the superiority of the proposed ADSum approach against state-of-the-art approaches.
Cloudberries—The Northern Gold

ABSTRACT Cloudberries are used fresh, as jam, in desserts, in yoghurt, in tea and in liquor. The limited season, its limited accessibility, and the lack of cultivation probably will keep the cloudberries scarce in the near future. Information about R. chamaemorus L. can be found in numerous papers written over a long period of time, but many of them are published in specialised publications not generally available. This manuscript provides a single source comprehensive review of cloudberries.
Lung Development Genes and Adult Lung Function

Rationale: Poor lung health in adult life may occur partly through suboptimal growth and development, as suggested by epidemiological evidence pointing to early life risk factors. Objectives: To systematically investigate the effects of lung development genes on adult lung function. Methods: Using UK Biobank data, we tested the association of 391 genes known to influence lung development with FVC and FEV1/FVC. We split the dataset into two random subsets of 207,616 and 138,411 individuals, using the larger subset to select the most promising signals and the smaller subset for replication. Measurements and Main Results: We identified 55 genes, of which 36 (16 for FVC, 19 for FEV1/FVC, and one for both) had not been identified in the largest, most recent genome-wide study of lung function. Most of these 36 signals were intronic variants; expression data from blood and lung tissue showed that the majority affect the expression of the genes they lie within. Further testing of 34 of these 36 signals in the CHARGE and SpiroMeta consortia showed that 16 replicated after Bonferroni correction and another 12 replicated at nominal significance level. Of the 55 genes, 53 fell into four biological categories whose function is to regulate organ size and cell integrity (growth factors; transcriptional regulators; cell-to-cell adhesion; extracellular matrix), suggesting that these specific processes are important for adult lung health. Conclusions: Our study demonstrates the importance of lung development genes in regulating adult lung function and influencing both restrictive and obstructive patterns. Further investigation of these developmental pathways could lead to druggable targets.
Early progression of breast cancer during neoadjuvant chemotherapy may predict poorer prognoses

Abstract Background: In Finland, breast cancers treated with neoadjuvant chemotherapy (NACT) are usually locally advanced and/or have an inflammatory phenotype. We evaluated early NACT responses in breast tumours and lymph nodes and their correlation with survival. Material and methods: We collected a retrospective dataset of 145 patients with very high-risk but non-metastasised breast cancers that were treated with NACT in a Finnish University Hospital between September 2013 and January 2019. The patients underwent magnetic resonance imaging (MRI) scans before beginning NACT and after every second NACT cycle thereafter. Results: The total pathological complete response rate was only 10.7% and breast cancer-specific survival (BCSS) at 24 months was 93.0%. The 2-year breast cancer-specific survival (BCSS) rate was 93.0%, but this varied from 86.5% for the triple-negative subtype to 100.0% for the luminal A-like subtype. Enlargement of the malignant axillary lymph nodes during the first two NACT cycles was associated with poor BCSS rates in HER2-negative patients (p = .00003 in the univariate analysis; hazard ratio = 26.3; 95% confidence interval = 2.66–259.6; p = .005 in the multivariate analysis). Furthermore, progression in the combined diameters of the breast tumours and axillary lymph nodes during the period between a patient’s pre-treatment MRI and her MRI after two NACT cycles was also correlated with worse BCSS rates in both univariate and multivariate analyses. Conclusions: An early MRI assessment after two NACT cycles, specifically of the tumour’s axillary lymph nodes, has the potential to predict short-term BCSS in patients with locally advanced HER2-negative breast cancers.
Leverage and muscle type in crab chelae (Crustacea: Brachyura)

The chelae of Cancer pagurus and Macropipus depurator were examined with respect to mechanical advantage. The closer muscles were investigated with respect to sarcomere length in the constituent fibres and to the force developed by the whole muscle during isometric contraction. Cancer chelae have a relatively high mechanical advantage, 0.329 ± 001. Cancer closer muscles contain a high proportion of fibres with long sarcomeres, mean lengths mostly falling between 12 and 15 μm, and develop a maximum stress of about 496 kN.m−2 during contraction. These figures are typical for “slow” crustacean muscle. The chelae of M. depurator are dimorphic. In one, the strong chela, the mechanical advantage is 0.248 ± 0.066 while in the other, the fast chela, the mechanical advantage is 0.177 ± 0.006. M. depurator closer muscles contain fibres with mean sarcomere lengths mostly falling between 6 and 10 μm. The muscle develops a maximum stress of about 145 kN.m−2 during contraction. These figures are typical of “intermediate” crustacean muscles. “Fast” muscle fibres with short sarcomeres (about 30 um) were found in the chelae of both Cancer and M. depurator but were much commoner in the latter. Thus in Cancer a high mechanical advantage is correlated with slow muscle while in M. depurator lower mechanical advantages are broadly correlated with faster muscle. Consistent correlation between mechanical advantage and muscle type in the dimorphic chelae of M. depurator, however, is lacking. No consistent regionation of fibres with similar properties was found in the muscles.
First record for the slug parasitic nematode, Phasmarhabditis hermaphrodita (Schneider) in Egypt

The rhabditid nematode, Phasmarhabditis hermaphrodita is a lethal parasite of certain terrestrial gastropods and has been shown as a biocontrol agent under laboratory and field conditions. In Egypt, P. hermaphrodita was isolated for the first time from different species of terrestrial gastropods found associated with various crops at Aga and Mansoura districts of Dakhalia Governorate during the year 2000/2001. Females and dauer larvae (IJs) were described and illustrated based on the light microscope. Males are not found as this species seemed to be protandrous. PCR analysis confirmed nematode identification. The Egyptian isolate of P. hermaphrodita was found to be shorter and lower in width than the British isolate. V%, a, b and c parameters showed detectable variations between two isolates with values of 54%, 17.7, 4.28, 13.7 in the Egyptian isolate, and 51%, 19.5, 7.2 and 15.8 for the British isolate, respectively.
Downregulation of p16 decreases biliary damage and liver fibrosis in the Mdr2-/- mouse model of primary sclerosing cholangitis.

Biliary senescence and hepatic fibrosis are hallmarks of cholangiopathies including primary sclerosing cholangitis (PSC). Senescent cholangiocytes display senescence-associated secretory phenotypes (SASPs, e. g., TGF-β1) that further increase biliary senescence (by an autocrine loop) and trigger liver fibrosis by paracrine mechanisms. To determine the effect of p16 inhibition and role of the TGF-β1/miR-34a/SIRT1 axis in biliary damage and liver fibrosis in the Mdr2-/- mouse model of PSC. We treated (i) in vivo male wild-type (WT) and Mdr2-/- mice with p16 Vivo-Morpholino or controls before measuring biliary mass (IBDM) and senescence, biliary SASPs levels and liver fibrosis; and (ii) in vitro intrahepatic murine cholangiocyte lines (IMCLs) with siRNA against p16 before measuring the mRNA expression of proliferation, senescence and fibrosis markers. p16 and miR-34a increased but SIRT1 decreased in Mdr2-/- mice and PSC human liver samples compared to controls. P16 immunoreactivity and biliary senescence and SASPs levels increased in Mdr2-/- mice but decreased in Mdr2-/- mice treated with p16 Vivo-Morpholino. The increase in IBDM and hepatic fibrosis (observed in Mdr2-/- mice) returned to normal values in Mdr2-/- mice treated with p16 Vivo-Morpholino. TGF-β1 immunoreactivity and biliary SASPs levels were higher in Mdr2-/- compared to those of WT mice, but returned to normal values in Mdr2-/- mice treated with p16 Vivo-Morpholino. The expression of fibrosis/senescence markers decreased in cholangiocytes from Mdr2-/- mice treated with p16 Vivo-Morpholino (compared to Mdr2-/- mice) and in IMCLs (after p16 silencing) compared to controls. Modulation of the TGF-β1/miR-34a/SIRT1 axis may be important in the management of PSC phenotype.
Biomonitoring of heavy metal (Cd, Cu, Pb, and Zn) concentrations in the west intertidal area of Peninsular Malaysia by using Nerita lineata

Snails, Nerita lineata, were collected from 15 sites along the west intertidal area of Peninsular Malaysia from December 2005 until April 2006. The concentrations of heavy metals (Cd, Cu, Pb, and Zn) were determined in the total soft tissues, operculums, and shells of the snails. Different patterns of heavy metal distributions were found in the different tissues (shell, operculums, and soft tissues) as well as spatial variations of heavy metal concentrations in the snails. This shows that the distribution of metals in the shells and the total soft tissues of N. lineata were not similar which could be due to different rates of metal accumulation, excretion, and sequestration. Since N. lineata is abundant on the rocky shores, below jetties and mangrove trees along the west intertidal area of Peninsular Malaysia and accumulate heavy metals, the snails are therefore potential biomonitors of heavy metal contamination for the west intertidal area of Peninsular Malaysia.
Comparison of the effects of different weekly frequencies of resistance training on metabolic health markers and body fat in older women.

BACKGROUND The purpose of this study was to compare the effects of a 24-week resistance-training (RT) program performed 2 vs. 3 times per week on body fat and metabolic health markers in older women. METHODS Thirty-nine women (≥60 years old) were randomly assigned to two groups according to RT frequency (G2x=two sessions per week, N.=19; and G3x=three sessions per week, N.=20) and were submitted to two 12-week stages of whole-body RT. In the first stage, participants performed 1 set of 10 to 15 repetitions in each of eight exercises, whereas in the second stage, they performed 2 sets of 10 to 15 repetitions. Body fat was estimated by DXA, while biochemical analyses were performed on venous blood samples collected in the morning hours after a 12 hours' fasting and after a minimum of 48 hours since the last physical exercise session. RESULTS After the 24 weeks of RT, only G3x significantly reduced body fat mass (G2x=0.0%; G3x=-5.1%), whereas both G2x and G3x reduced blood glucose and C-reactive protein levels. Both groups improved HDL-C after the first 12-week stage compared to baseline, although the changes from pre- to post-training were not significantly different between groups. No significant difference was observed compared to baseline for total cholesterol, VLDL-C, LDL-C, and triglycerides for either group. CONCLUSIONS These results suggest that RT-induced changes in health markers may occur regardless of RT frequency, whereas performing RT three times per week may be needed for reducing total body fat mass in older women.
A Comprehensive Repertoire of Transfer RNA-Derived Fragments and Their Regulatory Networks in Colorectal Cancer

To provide systematic insight into the composition and expression of transfer RNA (tRNA) derivatives transcriptome in colorectal cancer (CRC). tRNA derivatives expression profiles in three pairs of CRC and adjacent normal colon tissues were performed by tRNA-derived small RNA fragments (tRFs) and tRNA halves (tiRNA) sequencing, and microarray data of transcriptomes from CRC and paired controls were retrieved from Gene Expression Omnibus database. The differentially expressed tRFs and tiRNAs and differentially expressed genes between CRC and paired normal samples were screened. The functional regulations between tRF and tiRNA and gene were identified. A total of 60 upregulated and 48 downregulated tRNA derivatives and 7373 upregulated and 12,138 downregulated messenger RNA (mRNA) were identified. The tRF and tiRNA-gene regulatory modules were constructed by analyzing computational tRF and tiRNA-target predictions and inverse expression relationships between tRF and tiRNAs and mRNA. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway annotation showed that the function of targets of tiRNA-Tyr-GTA was mainly enriched in negative regulation of epithelial cell apoptotic process and peroxisome proliferator activated-receptors (PPAR) signaling pathway. Cellular response to monoamine stimulus and inflammatory bowel disease was enriched in function of tiRNA-Val-CAC. Two functions, including negative regulation of c-Jun N-terminal kinase (JNK) cascade and choline metabolism in cancer, were enriched in tRF-Gln-CTG. The function of mesenchymal to epithelial transition was enriched in tRF-Leu-TAG. For the first time to our knowledge, our study provided a landscape of tRNA derivatives expression profiles in CRC. Further tRF and tiRNA-gene regulatory modules construction explored the potential functions related to these tRNA derivatives in the pathogenesis of CRC.
Mechanical Properties of C3N Nanotubes from Molecular Dynamics Simulation Studies

Although the properties of carbon nanotubes (CNTs) are very well-known and are still extensively studied, a thorough understanding of other carbon-based nanomaterials such as C3N nanotubes (C3NNTs) is still missing. In this article, we used molecular dynamics simulation to investigate the effects of parameters such as chirality, diameter, number of walls, and temperature on the mechanical properties of C3N nanotubes, C3N nanobuds, and C3NNTs with various kinds of defects. We also modeled and tested the corresponding CNTs to validate the results and understand how replacing one C atom of CNT by one N atom affects the properties. Our results demonstrate that the Young’s modulus of single-walled C3NNTs (SWC3NNTs) increased with diameter, irrespective of the chirality, and was higher in armchair SWC3NNTs than in zigzag ones, unlike double-walled C3NNTs. Besides, adding a second and then a third wall to SWC3NNTs significantly improved their properties. In contrast, the properties of C3N nanobuds produced by attaching an increasing number of C60 fullerenes gradually decreased. Moreover, considering C3NNTs with different types of defects revealed that two-atom vacancies resulted in the greatest reduction of all the properties studied, while Stone–Wales defects had the lowest effect on them.
Phylogeny of Arrhopalites s.l. (Collembola : Symphypleona : Arrhopalitidae): testing the monophyly of the recently erected genera Arrhopalites s.s. and Pygmarrhopalites

The genus Arrhopalites (Arrhopalitidae) was proposed by Borner for Symphypleona with separate anal and genital segments, a single bothriotricha on the fifth abdominal segment and lacking capitate tenent hairs. Recently, chaetotaxic features were discovered and used to support a division of the genus into Arrhopalites s.s. for species in the coecus-group and Pygmarrhopalites for the pygmaeus-group s.l. species. A phylogenetic analysis of the genus Arrhopalites s.l. was performed using morphologic data to test its monophyly and the recent proposal to subdivide it into two genera. Results indicate that the genus Arrhopalites s.s. is monophyletic whereas the newly erected genus Pygmarrhopalites is paraphyletic, rendering a non-natural taxon.
Mutations in GET4 disrupt the transmembrane domain recognition complex pathway

The transmembrane domain recognition complex (TRC) targets cytoplasmic C‐terminal tail‐anchored (TA) proteins to their respective membranes in the endoplasmic reticulum (ER), Golgi, and mitochondria. It is composed of three proteins, GET4, BAG6, and GET5. We identified an individual with compound heterozygous missense variants (p.Arg122His, p.Ile279Met) in GET4 that reduced all three TRC proteins by 70% to 90% in his fibroblasts, suggesting a possible defect in TA protein targeting. He presented with global developmental delay, intellectual disabilities, seizures, facial dysmorphism, and delayed bone age. We found the TA protein, syntaxin 5, is poorly targeted to Golgi membranes compared to normal controls. Since GET4 regulates ER to Golgi transport, we hypothesized that such transport would be disrupted in his fibroblasts, and discovered that retrograde (but not anterograde) transport was significantly reduced. Despite reduction in the three TRC proteins, their mRNA levels were unchanged, suggesting increased degradation in patient fibroblasts. Treating fibroblasts with the FDA‐approved proteasome inhibitor, bortezomib (10 nM), restored syntaxin 5 localization and nearly normalized the levels of all three TRC proteins. Our study identifies the first individual with GET4 mutations.
IL-4 and SDF-1 Increase Adipose Tissue-Derived Stromal Cell Ability to Improve Rat Skeletal Muscle Regeneration

Skeletal muscle regeneration depends on the satellite cells, which, in response to injury, activate, proliferate, and reconstruct damaged tissue. However, under certain conditions, such as large injuries or myopathies, these cells might not sufficiently support repair. Thus, other cell populations, among them adipose tissue-derived stromal cells (ADSCs), are tested as a tool to improve regeneration. Importantly, the pro-regenerative action of such cells could be improved by various factors. In the current study, we tested whether IL-4 and SDF-1 could improve the ability of ADSCs to support the regeneration of rat skeletal muscles. We compared their effect at properly regenerating fast-twitch EDL and poorly regenerating slow-twitch soleus. To this end, ADSCs subjected to IL-4 and SDF-1 were analyzed in vitro and also in vivo after their transplantation into injured muscles. We tested their proliferation rate, migration, expression of stem cell markers and myogenic factors, their ability to fuse with myoblasts, as well as their impact on the mass, structure and function of regenerating muscles. As a result, we showed that cytokine-pretreated ADSCs had a beneficial effect in the regeneration process. Their presence resulted in improved muscle structure and function, as well as decreased fibrosis development and a modulated immune response.
Previous recreational cold exposure does not alter endothelial function or sensory thermal thresholds in the hands or feet

What is the central question of this study? Does recreational cold exposure result in cold sensitivity and is this associated with endothelial dysfunction and impaired sensory thermal thresholds? What is the main finding and its importance? Previous cold exposure was correlated with cold sensitivity of the foot, which might indicate the development of a subclinical non‐freezing cold injury. Endothelial function and thermal detection were not impaired in cold‐sensitive individuals; therefore, further research is required to understand the pathophysiology of subclinical and clinical forms of non‐freezing cold injury.