Miracle-dz/UniFAR-FTUs huggingface dataset:
Common SSRI side-effects in older adults associated with genetic polymorphisms in the serotonin transporter and receptors: Data from a randomized controlled trial

, Abstract Objective— Antidepressant side-effects are a significant public health issue, associated with poor adherence, premature treatment discontinuation and in rare cases significant harm. This is especially relevant for older adults, who assume the largest and most serious burden of medication side-effects. We investigated the association between antidepressant side-effects and genetic variation in the serotonin system in anxious, older adults participating in a randomized, placebo-controlled trial of the SSRI escitalopram. Method— Adults (n=177) aged ≥ 60 years were randomized to active treatment or placebo for 12-weeks. Side-effects were assessed using the UKU side effect rating scale. Genetic polymorphisms were putative functional variants in the promoters of the serotonin transporter and 1A and 2A receptors (5-HTTLPR (L/S + rs25531), HTR1A rs6295, HTR2A rs6311, respectively). Results— Four significant drug-placebo side-effect differences were found, including increased duration of sleep, dry mouth, diarrhea and diminished sexual desire. Analyses using putative high-vs low-transcription genotype groupings revealed 6 pharmacogenetic effects: greater dry mouth and decreased sexual desire for the low- and high-expressing genotypes of the serotonin transporter, respectively, and greater diarrhea with the low-transcription genotype of the 1A receptor. Diminished sexual desire was experienced significantly more in those with high-expressing genotype and either the serotonin transporter, 1A or significant relationship between drug concentration and side-effects nor a mean difference in drug concentration between low- and high-expressing genotypes. Conclusion— Genetic variation in the 5HT system may predict who develops common SSRI side-effects and why. More work is needed to further characterize this genetic modulation and to translate research findings into strategies useful for more personalized patient care.
Two novel mutations in TpreMPRSS6 associated with iron-refractory iron deficiency anemia in a mother and child

In an iron deficient child, oral iron repeatedly failed to improve the condition. Whole exome sequencing identified one previously reported plus two novel mutation in the TMPRSS6 gene, with no mutations in other iron-associated genes. We propose that these mutations result in a novel variety of iron-refractory iron deficiency anemia.
Novel health monitoring method using an RGB camera

: In this paper we present a novel health monitoring method by estimating the heart rate and respiratory rate using an RGB camera. The heart rate and the respiratory rate are estimated from the photoplethysmography (PPG) and the respiratory motion. The method mainly operates by using the green spectrum of the RGB camera to generate a multivariate PPG signal to perform multivariate de-noising on the video signal to extract the resultant PPG signal. A periodicity based voting scheme (PVS) was used to measure the heart rate and respiratory rate from the estimated PPG signal. We evaluated our proposed method with a state of the art heart rate measuring method for two scenarios using the MAHNOB-HCI database and a self collected naturalistic environment database. The methods were furthermore evaluated for various scenarios at naturalistic environments such as a motion variance session and a skin tone variance session. Our proposed method operated robustly during the experiments and outperformed the state of the art heart rate measuring methods by compensating the eﬀects of the naturalistic environment.
Examining Future Adolescent HPV Vaccine Uptake With and Without a School Mandate

Purpose— To develop a model of adolescent HPV vaccine utilization that explored future HPV vaccination rates with and without a school mandate for the vaccine at middle school entry. Methods— A dynamic, population-based, compartmental model was developed that estimated over a 50 year time horizon HPV vaccine uptake among female adolescents living in the U.S. The model incorporated data on parental attitudes about this vaccine and adolescent health care utilization levels. Results— Without a mandate, our model predicted that 70% coverage, a lower threshold value used in many previous modeling studies of HPV vaccination, would not be achieved until a mean of 23 years after vaccine availability. Maximal coverage of 79% was achieved after 50 years. With a school mandate in place, utilization increased substantially, with 70% vaccination coverage achieved by year 8 and maximal vaccination coverage, 90%, achieved by year 43. Conclusions— Our results suggest that vaccine utilization is likely to be low for several years, though strong school mandates might improve HPV vaccine uptake. These results impact the interpretation of previous modeling studies that estimated the potential clinical impacts of HPV vaccination under assumptions of very high vaccine utilization rates.
3D-Printed Gastric Resident Electronics

Long‐term implantation of biomedical electronics into the human body enables advanced diagnostic and therapeutic functionalities. However, most long‐term resident electronics devices require invasive procedures for implantation as well as a specialized receiver for communication. Here, a gastric resident electronic (GRE) system that leverages the anatomical space offered by the gastric environment to enable residence of an orally delivered platform of such devices within the human body is presented. The GRE is capable of directly interfacing with portable consumer personal electronics through Bluetooth, a widely adopted wireless protocol. In contrast to the passive day‐long gastric residence achieved with prior ingestible electronics, advancement in multimaterial prototyping enables the GRE to reside in the hostile gastric environment for a maximum of 36 d and maintain ≈15 d of wireless electronics communications as evidenced by the studies in a porcine model. Indeed, the synergistic integration of reconfigurable gastric‐residence structure, drug release modules, and wireless electronics could ultimately enable the next‐generation remote diagnostic and automated therapeutic strategies.
Inter-Criteria Dependencies-Based Decision Support in the Sustainable wind Energy Management

Decision problems related to the wind energy require considering many, often interrelated and dependent on each other, criteria. To solve such problems, decision systems based on Multi-Criteria Decision Analysis (MCDA) methods are usually used. Unfortunately, most methods assume independence between the criteria, therefore, their application in decision problems related to the wind energy is debatable. This paper presents the use of the Analytic Network Process (ANP) method to solve a decision problem consisting in selecting the location and design of a wind farm. The use of the ANP method allows capturing the complexity of the decision problem by taking into consideration dependencies between criteria. As part of the verification of the solution, the results of the ANP method were compared with those of the Analytic Hierarchy Process (AHP) method, which uses only hierarchical dependencies between criteria. The conducted verification showed that the inter-criteria dependencies may have a significant influence on the obtained solution. On the basis of the conducted sensitivity analysis and the research into robustness of the rankings to the rank reversal phenomenon, it has been found out that the ranking obtained with the use of the ANP is characterized by a higher quality than by means of the AHP.
Comparison CCEM-K4.2017 of 10 pF and 100 pF capacitance standards

In 2017 the Consultative Committee for Electricity and Magnetism (CCEM) commissioned a key comparison of electrical capacitance standards, the second time this quantity has been compared since the implementation of the Mutual Recognition Agreement by the Comité International des Poids et Mesures (CIPM—MRA) in 1999. This comparison—CCEM-K4.2017—was piloted by the Bureau International des Poids et Mesures (BIPM) and included seven National Metrology Institutes (NMI) belonging to four Regional Metrology Organizations. The measuring scheme adopted for the comparison was that of a star comparison consisting of a set of bilateral comparisons between the participating NMIs and the BIPM, whose capacitance reference base served as a common reference. For each of the bilateral comparisons, the measurands were the capacitance values of 10 pF travelling standard capacitors belonging to the NMIs and, optionally, the values of 100 pF standards. All the participants have been chosen from those able to realize and maintain a representation of the farad at the best known level of accuracy. Four of them, including the BIPM, were taking their traceability from dc or ac quantum Hall effect standards and, the four others, from a calculable capacitor. The comparison results analysis have evidenced an agreement within about ±5 parts in 108 for the mandatory 10 pF measurements and within about ±10 parts in 108 for the optional 100 pF measurements. Also, excepted for one of the participants, a good agreement has been found for the ratio 100 pF:10 pF (within ±5 parts in 108). In addition to the comparison, it has been possible to evaluate the difference between the value of R K (von Klitzing constant) measured by electrical means from calculable capacitors and its last CODATA recommended value (CODATA 2014 adjustment). A difference of (43 ± 23) parts in 109 (k = 1) has been found which is consistent with the difference that can be computed from the experimental data used in the CODATA 2014 adjustment of fundamental constants. This report presents the details of the measurements and analysis having led to these results. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm. org/. The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
c-myc, BiP, and eIF4G conferred by internal ribosome Cap-independent polysomal association of natural mRNAs

Sequence elements that can function as internal ribosome entry sites (IRES) have been identified in 5 9 noncoding regions of certain uncapped viral and capped cellular mRNA molecules. However, it has remained largely unknown whether IRES elements are functional when located in their natural capped mRNAs. Therefore, the polysomal association and translation of several IRES-containing cellular mRNAs was tested under conditions that severely inhibited cap-dependent translation, that is, after infection with poliovirus. It was found that several known IRES-containing mRNAs, such as BiP and c-myc, were both associated with the translation apparatus and translated in infected cells when cap-dependent translation of most host-cell mRNAs was blocked, indicating that the IRES elements were functional in their natural mRNAs. Curiously, the mRNAs that encode eukaryotic initiation factor 4GI (eIF4GI) and 4GII (eIF4GII), two proteins with high identity and similar functions in the initiation of cap-dependent translation, were both associated with polysomes in infected cells. The 5 9 -end sequences of eIF4GI mRNA were isolated from a cDNA expression library and shown to function as an internal ribosome entry site when placed into a dicistronic mRNA. These findings suggest that eIF4G proteins can be synthesized at times when 5 9 cap-dependent mRNA translation is blocked, supporting the notion that eIF4G proteins are needed in both 5 9 cap-independent and 5 9 cap-dependent translational initiation mechanisms.
AXIN2 , Orofacial Clefts and Positive Family History for Cancer

Background— Cancer and congenital malformations may occasionally have a common etiology. We investigated if families segregating orofacial clefts (CL/P) presented increased cancer incidence when compared to control families. Methods— We assessed 75 CL/P families and 93 control families of Caucasian ethnicity from Pittsburgh regarding positive history of cancer. Chi-square and Fisher exact tests were used to determine significant differences. Then, we performed molecular studies with genes in which mutations have been independently associated with both cancer and craniofacial anomalies. Results— CL/P families reported positive family history of cancer more often than control families (p=0.0002), and had higher rates of specific cancer types: colon (p=0.0009), brain (p=0.003), leukemia (p=0.005), breast (p=0.009), prostate (p=0.01), skin (p=0.01), lung (p=0.02), and liver (0.02). Overtransmission of AXIN2 was detected in CL/P probands (p=0.003). Conclusion— Families segregating CL/P may have an increased susceptibility for cancer, notably colon cancer. Further, AXIN2 , a gene that when mutated increases susceptibility to colon cancer, is also associated with CL/P. Clinical Implications— Individuals detected at a higher risk for disease predisposition will be able to adopt a better lifestyle avoiding exposure to other risk factors that may interact with the individual’s genotype.
Behavior Classification Algorithms at Intersections

The ability to classify driver behavior lays the foundation for more advanced driver assistance systems. Improving safety at intersections has also been identified as high priority due to the large number of intersection related fatalities. This paper focuses on developing algorithms for estimating driver behavior at road intersections. It introduces two classes of algorithms that can classify drivers as compliant or violating. They are based on 1) Support Vector Machines (SVM) and 2) Hidden Markov Models (HMM), two very popular machine learning approaches that have been used extensively for classification in multiple disciplines. The algorithms are successfully validated using naturalistic intersection data collected in Christiansburg, VA, through the US Department of Transportation Cooperative Intersection Collision Avoidance System for Violations (CICAS-V) initiative.
Factores que influyen en la calidad de vida de pacientes con cáncer de colon y recto

Objective: To conduct an integrative literature review and evaluate the evidence regarding quality of life of patients with colon and rectal cancer. Methods: A literature search was conducted between 1997 and 2007 using the LILACS, CINAHL and MEDLINE databases. Results: The diagnosis and treatment of cancer affect several domains of quality of life of the sample of patients. A number of factors, such as, engaging in exercise, increased physical conditioning, good nutrition, and psychosocial support led to better quality of life. Conclusions: There was a lack of national publications, few publications by registered nurses, the predominance of descriptive studies, and weak level of evidence. We recommend that registered nurses conduct experimental studies to evaluate the effect of psychosocial interventions and physical activity programs in improving the quality of life of patients with cancer.
Acknowledging the role of stigma and medical mistrust in engagement in routine health care among Black men who have sex with men

, Abstract Background— Although HIV infections are documented among all race and sexual risk groups, black men who have sex with men (BMSM) are the most affected by HIV in the US. Currently, there is considerable emphasis on the implementation and use of biomedical HIV prevention to slow the HIV epidemic among this group; however, use of biomedical prevention requires engagement in routine medical care – a necessity that has not been met. Methods— In order to better understand this shortcoming, we surveyed 544 BMSM (in 2012) to assess how health care related stigma, global medical mistrust, and personal trust in health care provider relate to engaging in medical care. We used generalized linear modeling and mediation analyses to assess data (completed in 2013). Results— Twenty nine percent of participants reported experiencing race/sexual orientation stigma from heath care providers and 48% reported feelings of mistrust towards medical establishments. In generalized linear modeling we found that, among HIV negative BMSM, those who experienced greater stigma and global medical mistrust had longer gaps in time since last medical exam. Furthermore, global medical mistrust mediated the relationship between stigma and engagement in care. Among HIV positive BMSM, experiencing stigma from health care providers was also associated with longer gaps in time since last HIV care appointment. Conclusions— Interventions that support the development of greater awareness around the sexual health needs of BMSM are desperately needed. Failure to address psychosocial deterrents will stymie progress made in biomedical prevention and, ultimately, cripple our ability to implement these technologies.
Robust Scale Adaptive Visual Tracking with Correlation Filters

Visual tracking is a challenging task in computer vision due to various appearance changes of the target object. In recent years, correlation filter plays an important role in visual tracking and many state-of-the-art correlation filter based trackers are proposed in the literature. However, these trackers still have certain limitations. Most of existing trackers cannot well deal with scale variation, and they may easily drift to the background in the case of occlusion. To overcome the above problems, we propose a Correlation Filters based Scale Adaptive (CFSA) visual tracker. In the tracker, a modified EdgeBoxes generator, is proposed to generate high-quality candidate object proposals for tracking. The pool of generated candidate object proposals is adopted to estimate the position of the target object using a kernelized correlation filter based tracker with HOG and color naming features. In order to deal with changes in target scale, a scale estimation method is proposed by combining the water flow driven MBD (minimum barrier distance) algorithm with the estimated position. Furthermore, an online updating schema is adopted to reduce the interference of the surrounding background. Experimental results on two large benchmark datasets demonstrate that the CFSA tracker achieves favorable performance compared with the state-of-the-art trackers.
Hematopoietic Stem Cell Origin of Human Fibroblasts: Cell Culture Studies of Female Recipients of Gender Mismatch Stem Cell Transplantation and Patients with Chronic Myelogenous Leukemia

Objectives— Our series of studies using transplantation of single hematopoietic stem cells (HSCs) demonstrated that mouse fibroblasts/myofibroblasts are derived from HSCs. In order to determine the origin of human fibroblasts, we established a method for culturing fibroblasts from human peripheral blood (PB) mononuclear cells and studied fibroblasts from gender mismatch HSC transplant recipients and patients with untreated Philadelphia chromosome-positive chronic myelogenous leukemia (CML). Methods— We cultured PB cells from three female subjects who showed near complete hematopoietic reconstitution from transplantation of granulocyte-colony stimulating factor (G-CSF)-mobilized male PB cells and examined the resulting fibroblasts using fluorescent in situ hybridization (FISH) for Y chromosome. Because the mobilized PB cells may contain mesenchymal stem cells (MSCs), we could not determine the HSC or MSC origin of the fibroblasts seen in culture. To further document the HSC origin of human fibroblasts, we next examined fibroblasts from two patients with untreated CML, a known clonal disorder of HSCs. Results— All cultured fibroblasts from female recipients of male cells showed the presence of Y-chromosome, indicating the donor origin of fibroblasts. Cultured fibroblasts from the CML patients revealed the presence of BCR-ABL translocation. This demonstration provided strong evidence Conclusions— These studies strongly suggest that human fibroblasts are derived from HSCs. In addition, the results suggest that fibrosis seen in patients with CML may be a part of the clonal process. Real-time RT-PCR was conducted on total RNA extracted from PB MNCs, cultured fibroblasts and a human foreskin fibroblast cell line (HFF-1). Analysis showed that cultured human fibroblasts expressed mRNA for pro-collagen I α 1, vimentin and fibronectin at levels similar to a HFF-1 and far higher than those by PB MNCs. These findings provide biochemical support for the identity of the cultured cells as fibroblasts.
Water footprint assessment considering intermediate products: model and a 2016 case study of China

Analysing intermediate products within a water footprint (WF) across different economic sectors can show the root causes of water usage and is helpful for water resource management and policy making. However, conventional methods and data for a WF rarely assess the input and output of intermediate products directly and comprehensively. Therefore, this study proposes an approach to access the WF of intermediate products as well as final products in each sector of an economy’s water sustainability profile. An Economic Input‐output‐based Life‐Cycle Assessment (EIO‐LCA) framework is designed for the accounting, which describes the intermediate WF products of each sector in a material‐product network. This method is implemented into a 2016 case study for a comprehensive Chinese WF. The results showed that the total WF of Chinese inhabitants (consumers) in 2016 was 5.76 × 1011 m3, and the top three sectors with the largest WF were agriculture (1.78 × 1011 m3), food (1.05 × 1011 m3) and machinery manufacturing (5.68 × 1010 m3); agriculture provided the largest quantity of virtual water contained in its intermediate product for the other sectors. From the perspective of producers, the total WF of the Chinese economic sectors in 2016 was 5.84 × 1011 m3. The sectors with the largest direct water use were agriculture (2.20 × 1011 m3), electricity (7.64 × 1010 m3) and chemical Industry (2.35 × 1010 m3); and large parts of their direct water usage were consumed to prepare intermediate products for other sectors. The results of this study show that a more inclusive approach provides an enhanced qualitative and resource‐ethical view for water accounting and management.
Physician Perceptions of the Performance and Importance of Consultant Pharmacist Services Associated with an Intervention for the Detection and Management of Adverse Drug Events in the Nursing Home

Corresponding Author Information: Sandra L. Kane-Gill, PharmD, MS, FCCM, FCCP, School of Pharmacy, University of Pittsburgh, 918 Salk Hall, 3501 Terrace St., Pittsburgh, PA 15261, 412-624-5150 (phone), 412-624-1850 (fax), SLK54@pitt.edu. Competing interests/conflicts of interests: None. Ethics approval: Ethics approval was provided by the University of Pittsburgh. HHS Public Access Author manuscript Consult Pharm. Author manuscript; available in PMC 2017 November 06.