Miracle-dz/UniFAR-FTUs huggingface dataset:
Running Head: SELF-AMBIVALENCE IN OCD An investigation of self-ambivalence in Obsessive-Compulsive Disorder.

Individuals vulnerable to obsessive-compulsive disorder (OCD) are hypothesized to have ambivalence about their self-worth, morality and lovability [Guidano, V. , & Liotti, G. (1983). Cognitive processes and emotional disorders . New York: Guildford Press]. The purpose of this study was to examine whether self-ambivalence was associated with OCD phenomena and beliefs relevant to OCD. It also examined whether patients with OCD had higher levels of self-ambivalence compared to non-clinical controls and patients with other anxiety disorders. Participants were 73 OCD patients, 50 patients with another anxiety disorder, 225 non-clinical undergraduate students and 43 non-clinical community controls. They completed measures of self-ambivalence, OCD phenomena, OCD-relevant beliefs, depression, anxiety and self-esteem. Self-ambivalence was significantly associated with OCD phenomena and OCD-relevant beliefs, after controlling for self-esteem, depression and anxiety. Further, OCD participants were significantly more ambivalent than the non-clinical groups, but did not differ from anxious controls. It was argued that these results provide a basis for extending the cognitive-behavioral model of OCD to include ambivalent self-perceptions as a component of the cognitive mechanisms relevant to the disorder. Individuals with OCD showed higher levels of self-ambivalence than non-clinical individuals, but no difference was found between the OCD group and anxious controls. Collectively, these findings are consistent with the possibility that self-ambivalence functions as a non-specific vulnerability or maintaining factor for OCD. Further research is required to examine such causal postulation, but this study provides a basis for extending the cognitive-behavioral model of OCD to include ambivalent self-perceptions as a component of the cognitive mechanisms relevant to the disorder.
A meta-analysis for ef ﬁ cacy and safety evaluation of transcatheter left atrial appendage occlusion in patients with nonvalvular atrial ﬁ brillation

Objectives: This meta-analysis was conducted to evaluate the ef ﬁ cacy and safety of transcatheter left atrial appendage (LAA) occlusion in patients with nonvalvular atrial ﬁ brillation. Methods: The randomized controlled trials (RCT) or observational studies with any transcatheter LAA occlusion devices were searched in PubMed, Embase, and Cochrane library from inception to November 2015. The incidence rates from individual studies were combined to evaluate the procedural ef ﬁ cacy and safety, including all-cause death, cardiac/neurological death, stroke, transient ischemic attack (TIA), thrombosis, hemorrhagic complications, and pericardial effusion/tamponade. Results: Thirty-eight studies involving 3585 patients and 6 different occlusion devices were eligible for our inclusion criteria. The procedural failure rate for LAA closure was 0.02 (95% CI: 0.02 – 0.03). The all-cause mortality was 0.03 (95% CI: 0.02 – 0.03) and cardiac/neurological mortality was 0 (95% CI: 0.00 – 0.01). The stroke/TIA rate was estimated only 0.01 (95% CI: 0.01 – 0.01). The incidence of thrombus on devices was 0.01 (95% CI: 0.01 – 0.02). The major hemorrhagic complication rate was estimated 0.01 (95% CI: 0.00 – 0.01). Pericardial effusion/tamponade was estimated 0.02 (95% CI: 0.02 – 0.03). No heterogeneity was observed for above pooled estimates ( I 2 = 0). In devices subgroups analysis, the all-cause mortality and cardiac/neurological mortality of PLAATO group were the highest ( P = 0.01 and P < 0.01 respectively), whereas the incidence of thrombus on devices in the ACP group was the highest ( P < 0.01). In follow-up period subgroups analysis, there were signi ﬁ cant differences in all-cause death, stroke/TIA, major hemorrhage, and pericardial effusion/tamponade events between the shorter and longer follow-up period subgroups ( P < 0.05). However, the differences among the subgroups were numerically small. Conclusions: the pooled data demonstrated that transcatheter LAA occlusion was effective and safe in the patients with nonvalvular atrial ﬁ brillation who were not suitable for lifelong antithrombotic therapy.
Comparative Study of Corneal Biomechanical Properties between Myopes and Hyperopes

Purpose: The aim of this study is to compare the biomechanical corneal properties between myopes and hyperopes among Saudi Arabian adults using an Ocular Response Analyzer. Methods: The study involves 50 healthy Saudi Arabian adults: 18 males (35.35 %) and32 females (64.65%), with a mean age 25.66 ± 5.8 years (range 15 – 44). The subjects were divided into two groups: Group 1 includes 78 eyes of 39 myopic subjects with spherical equivalents ranging from -1.25 DS to -10.00 DS; Group 2 includes 21 eyes of 11 hyperopic subjects with spherical equivalents ranging from +1.00 DS to +5.50 DS. An Ocular Response Analyzer [Reichert Ophthalmic Instruments, Buffalo, USA] was used to measure the corneal biomechanical properties such as Corneal Hysteresis (CH), Corneal Resistance Factor (CRF), IOPcc and IOPg. The Pentacam [Oculus, Wetzler, Germany] was used to measure the Central Corneal Thickness (CCT). Results: This study found that CH has a highly significant correlation with spherical equivalent in hyperopes (r=0.684; P<0.001) compared with an insignificant correlation with spherical equivalent in myopes (r = - 0.009; P=0.939). Also, it was found that a highly significant difference between myopes and hyperopesin CH values exists (P<0.001). Our study did not show any significant correlation between CRF and spherical equivalent with myopes (r=0.071; P=0.536) or with hyperopes (r=0.357; P=0.112). A significant correlation was found between CCT and the amount of spherical equivalent in hyperopes (r = 0.510; P<0.001). In myopes the CCT had an insignificant correlation with the amount of spherical equivalent (r = - 0.013; P = 0.913). The amount of CCT in this study is significantly correlated with corneal hysteresis in myopia (r = 0.504;P< 0.0001) and in hyperopia (r = 0.651, P<0.001). In the myopia group of our study, it was found that CH had a significant correlation with IOPcc (r = - 0.640; P<0.0001) and was more significant than in hyperopic group (r = -0.457; P=0.037). Conclusion: In conclusion, this study found that hyperopic refractive errors have higher and significant values of corneal hysteresis and other biomechanical properties.
Herpes Simplex Virus Type 1 Suppresses RNA-Induced Gene Silencing in Mammalian Cells (cid:1)

RNA-induced silencing is a potent innate antiviral defense strategy in plants, and suppression of silencing is a hallmark of pathogenic plant viruses. However, the impact of silencing as a mammalian antiviral defense mechanism and the ability of mammalian viruses to suppress silencing in natural host cells have remained controversial. The ability of herpes simplex virus type 1 (HSV-1) to suppress silencing was examined in a transient expression system that employed an imperfect hairpin to target degradation of transcripts encoding enhanced green ﬂuorescent protein (EGFP). HSV-1 infection suppressed EGFP-speciﬁc silencing as demonstrated by increased EGFP mRNA levels and an increase in the EGFP mRNA half-life. The increase in EGFP mRNA stability occurred despite the well-characterized host macromolecular shutoff functions of HSV-1 that globally destabilize mRNAs. Moreover, mutant viruses defective in these functions increased the stability of EGFP mRNA even more than did the wild-type virus in silenced cells compared to results in control cells. The importance of RNA silencing to HSV-1 replication was conﬁrmed by a signiﬁcantly enhanced virus burst size in cells in which silencing was knocked down with small inhibitory RNAs directed to Argonaute 2, an integral component of the silencing complex. Given that HSV-1 encodes several microRNAs,
symposium article Novel tools in radiotherapy

In recent decades, it has been postulated that the role of radiotherapy could increasingly be replaced by medical targeted therapies based upon knowledge of molecular tumour pathways. However, recent progress has again underlined the pivotal role of radiotherapy in cancer treatment, both alone as illustrated by stereotactic radiotherapy (SRT), and also in combination with conventional chemotherapy and molecular targeted agents. Furthermore, the improved survival achieved with systemic treatment of diseases such as colorectal cancer [1] has increased the need for effective treatment of limited volume metastatic disease to the liver and lungs [2–4]. Local control with surgery or SRT is increasingly used in such patients in order to improve disease-free survival. This review will describe the new tools and approaches that are likely to improve current radiotherapy outcomes, including improved imaging techniques and the so-called image-guided radiotherapy (IGRT), in which the position of the tumour and/ or dose-limiting normal organs can be imaged during treatment.
IN – SILICO ANALYSIS OF NON- SYNONYMOUS SINGLE NUCLEOTIDE POLYMORPHISMS OF ACTIVATION- INDUCED CYTIDINE DEAMINASE (AICDA ) GENE

Introduction: The activation- induced cytidine deaminase (AICDA) enzyme is responsible for converting the immunoglobulin IgM to other classes (IgG, IgA and IgE). Immunodeficiency type2 with hyper serum IgM (HIGM2) is due to failure of AICDA gene to convert the IgM to other classes. The aim of this study was to investigate the effect of nsSNPs in the function and stability of (AICDA ) gene using computational tools. Prediction of protein stability using I-Mutant3.0 revealed that 9 SNPs lead to decrease protein stability while one mutation showed an increased stability effect. The change in the chemical nature of amino acid and how it effects the protein structure was analyzed using Project Hope. Overall five highly deleterious and damaging mutations were predicted namely, R24W (rs104894324), W80R (rs104894320), L106P (rs104894321) M139T(rs200858797) F151S (rs104894327). Conclusion: This study showed, after using various computer software, five highly deleterious and damaging SNPs in AICDA gene. These SNPs can be considered as candidate SNPs in people with HIGM2 after further conformation using laboratory techniques. reference SNPS, SIFT: sorting intolerant from tolerant, PHD-SNP: Predictor of Human Deleterious Single Nucleotide Polymorphism, SNP&GO: Single nucleotide polymorphisms and gene ontology SPTY2D1 : chromatin protein domain containing. 1STAT4 : signal transducer and activator of transcription. Indel: insertion deletion, aa: amino acid, Cds: Coding Sequence. UTR: un-translated region.
Structural Reliability Analysis of Cross Laminated Timber Plates Subjected to Bending

Failure modes of Cross Laminated Timber (CLT) plates reach by an excess of tensile stress on finger joints, shear stress on transverse layer due to rolling shear effect and by natural vibration. The Probability of Failure (POF) of CLT plates can be estimated from the probability distribution of their ruptures and stiffnesses, as well as their correlation coefficients. In this context, the aim of this paper is to estimate the load capacity of Cross Laminated Timber plates from a specific probability of failure and the experimental results of mechanical and physical properties. For this purpose, CLT plates were manufactured with wood species of Pinus taeda L. , from Brazilian reforestation plantations. Four-point bending tests were conducted to investigate the failure behavior of the CLT plates. Density and moisture content were obtained from small specimens extracted from these plates. Monte Carlo simulation was carried out to predict the probabilistic loads that produce the failure of CLT plates, considering the failure occasioned by natural vibration as well. Experimental and numerical results of the failure modes were compared and the maximum loads to an acceptable probability of failure of the several CLT lengths were estimated too.
(cid:2) v (cid:3) 3 Integrin Boosts the Innate Immune Response Elicited in Epithelial Cells through Plasma Membrane and Endosomal Toll-Like Receptors

We report that (cid:2) v (cid:3) 3 integrin strongly affects the innate immune response in epithelial cells. (cid:2) v (cid:3) 3 integrin greatly increased the response elicited via plasma membrane Toll-like receptors (TLRs) by herpes simplex virus or bacterial ligands. The endosomal TLR3, not the cytosolic sensor interferon gamma-inducible protein 16 (IFI16), was also boosted by (cid:2) v (cid:3) 3 integrin. The boosting was exerted speciﬁcally by (cid:2) v (cid:3) 3 integrin but not by (cid:2) v (cid:3) 6 or (cid:2) v (cid:3) 8 integrin. Current and previous work indicates that integrin-TLR cooperation occurs in epithelial and monocytic cells. The TLR response should be considered an integrin-TLR response.
Novel prion mutation (p.Tyr225Cys) in a Korean patient with atypical Creutzfeldt – Jakob disease Clinical Interventions in Aging

Background: A novel prion variant, PRNP p.Tyr225Cys (c.674A>G; p.Y225C), was identi ﬁ ed in an atypical Creutzfeldt – Jakob disease (CJD) patient. The patient had a 5-year history of progressive cognitive impairment with speech and gait disturbances. From the basic neurological examination at his ﬁ rst hospital visit, rigidity and myoclonic jerks in all limbs were observed without focal weakness. Electroencephalogram showed the diffuse slow continuous delta activity in the bilateral cerebral hemisphere. Magnetic resonance imaging revealed abnormalities in the brain, such as cortical signal changes and edema in the frontotemporoparietal lobes and the basal ganglia. Cerebrospinal ﬂ uid 14 – 3-3 protein analysis showed a weakly positive signal. Family history remained unclear, but the patient ’ s mother and sister were diagnosed with cognitive impairment but both refused genetic testing. Methods: Targeted next generation sequencing (NGS) was performed on 50 genes, involved in different neurodegeneratives diseases, such as Alzheimer's, Parkinson's, frontotemporal dementia or prion diseases. In silico analyses and structure predictions were performed on the potential patohgenic mutations. Results: NGS and standard sequencing revealed the novel PRNP p.Tyr225Cys mutation in the patient. Structure predictions revealed that this may make the helix more ﬂ exible. In addition, the extra cysteine residue in TM-III of prion protein may result in disturbances of natural disul ﬁ de bond. Conclusion: Hence, the pathogenicity of PRNP p.Tyr225Cys was not fully con ﬁ rmed at present, and its penetrance was suggested to be low. However, its possible pathogenic nature in prion diseases cannot be ignored, since Tyr/Cys exchange could disturb the helix dynamics and contribute to conformational alteration and disease progression.
Online Measurement of PM 2.5 at an Air Monitoring Supersite in Yangtze River Delta: Temporal Variation and Source Identiﬁcation

: To comprehensively explore the transport of air pollutants, one-year continuous online observation of PM 2.5 was conducted from 1 April 2015 to 31 March 2016 at Dianshan Lake, a suburban junction at the central of Yangtze River Delta. The chemical species of PM 2.5 samples mainly focused on Organic carbon (OC), Elemental carbon (EC) and Water-Soluble Inorganic Ions (WSIIs). The annual average of PM 2.5 concentration was 59.8 ± 31.7 µ g · m − 3 , 1.7 times higher than the Chinese National Ambient Air Quality Standards (CNAAQS) (35 µ g · m − 3 ). SNA (SO 42 − , NO 3 − and NH 4 + ) was the most dominated species of PM 2.5 total WSIIs, accounting for 51% of PM 2.5 . PM 2.5 and all of its chemical species shared the same seasonal variations with higher concentration in winter and spring, lower in autumn and summer. The higher NO 3 − / EC and NOR occurred in winter suggested that intensive secondary formation of nitrate contributed to the higher levels of PM 2.5 . Cluster analysis based on 72-h backward air trajectory showed that the air mass cluster from nearby inland cities, including Zhejiang, Anhui and Jiangxi Provinces contributed mostly to the total trajectories. Furtherly, potential source contribution function (PSCF) analysis revealed that local sources, namely the emissions in the Yangtze River, were the primary sources. During haze pollution, NO 3 − was the most important fraction of PM 2.5 and the heterogeneous formation of nitrate became conspicuous. All the results suggested that the anthropogenic emissions (such as tra ﬃ c exhaust) was responsible for the relatively high level of PM 2.5 at this monitoring station.
IMPAIRED SHP2-MEDIATED ERK ACTIVATION CONTRIBUTES TO GEFITINIB SENSITIVITY OF LUNG CANCER CELLS WITH EGFR-ACTIVATING MUTATIONS

Most non-small cell lung cancers (NSCLC) display elevated expression of epidermal growth factor receptor (EGFR), but response to EGFR kinase inhibitors is predominantly limited to NSCLC harboring EGFR-activating mutations. These mutations are associated with increased activity of survival pathways including PI3K/AKT and STAT3/5. We report that EGFR-activating mutations also surprisingly lead to decreased ability to activate ERK compared to wild-type EGFR. In NSCLC cells and mouse embryonic fibroblasts expressing mutant EGFR, this effect on ERK correlates with decreased EGFR internalization and reduced phosphorylation of SHP2, a tyrosine phosphatase required for the full activation of ERK. We further demonstrate that ERK activation levels impact cellular response to gefitinib. NSCLC cells with EGFR mutation display reduced gefitinib sensitivity when ERK activation is augmented by expression of constitutively active mutants of MEK. Conversely, in an NSCLC cell line expressing wild-type EGFR, gefitinib treatment along with or following MEK inhibition increases death response compared to treatment with gefitinib alone. Our results demonstrate that EGFR-activating mutations may promote some survival pathways but simultaneously impair others. This multivariate alteration of the network governing cellular response to gefitinib, which we term “oncogene imbalance”, portends a potentially broader ability to treat gefitinib-resistant NSCLC.
pathway proteins with in

: Objectives: Human studies on the role of mannose-binding lectin (MBL) in patients with invasive candidiasis have yielded conflicting results. We investigated the influence of MBL and other lectin pathway proteins on Candida colonization and intra-abdominal candidiasis (IAC) in a cohort of high-risk patients. Methods: Prospective observational cohort study of 89 high-risk intensive-care unit (ICU) patients. Levels of lectin pathway proteins at study entry and six MBL2 single-nucleotide polymorphisms were analysed by sandwich-type immunoassays and genotyping, respectively, and correlated with development of heavy Candida colonization (corrected colonization index (CCI) >0.4) and occurrence of IAC during a 4-week period. Results: Within 4 weeks after inclusion a CCI>0.4 and IAC was observed in 47% and 38% of patients respectively. Neither serum levels of MBL, ficolin-1,-2,-3, MASP-2 or collectin liver 1 nor MBL2 genotypes were associated with a CCI>0.4. Similarly, none of the analysed proteins was found to be associated with IAC with the exception of lower MBL levels (HR 0.74, p=0.02) at study entry. However, there was no association of MBL deficiency (<0.5 µg/ml), MBL2 haplo- or genotypes with IAC. Conclusion: Lectin pathway protein levels and MBL2 genotype investigated in this study were not associated with heavy Candida colonization or IAC in a cohort of high-risk ICU patients. years old surgical ICU patients recurrent GIT perforation or acute necrotizing pancreatitis not receiving antifungal agents were included and prospectively studied until 2 weeks after ICU discharge. A complete description of the study including information about clinical workup, recorded clinical variables, microbiological sampling and treatment has been reported previously(25). Blood samples for genetic testing and determination of protein levels were drawn at study inclusion. During the study period, at least three of five nonsterile sites (mouth, stool, skin, respiratory tract) were screened twice weekly for colonization with Candida spp . and or heavy according to semiquantitative Time-dependent analysis (Cox regression) of clinical endpoints and lectin pathway proteins during the 4-week high-risk period considering the diagnosis of recurrent gastrointestinal perforation or acute necrotizing pancreatitis as the starting date, with censoring at death or ICU discharge. HR>1 corresponds to an increased risk. Time-dependent analysis (Cox regression, dominant model of inheritance (wildtype vs. hetero- and homozygous)) of clinical endpoints and MBL2 SNPs, haplo-and genotypes proteins during the 4-week high-risk period considering the diagnosis of recurrent gastrointestinal perforation or acute necrotizing pancreatitis as the starting date, with censoring at death or ICU discharge. MBL2 genotypes were classified as low (XA/YO, YO/YO), intermediate (XA/XA, YA/YO) or high (YA/YA, XA/YA) with exon variant alleles collectively designated as O and the wild-type gene as A, and the promoter variant allele (rs7096206) and the wild-type gene designated as X and Y, respectively. HR>1 corresponds to an increased risk.
Analysis and Prediction of Soybean Plant Disease

- Disease detection of the plant is one of the absorbing research areas in the farming field. This field needs a dependable prediction methodology to understand elements influencing disease. Plant diseases become major threats for us because it harms our body by reducing our immune system and also degrade the quality of crops. As the production of soybean is decreased due to natural hazard, overuse of pesticides, soil problem, and lack of agricultural knowledge and mainly due to diseases.
Human Detection using Mobile Embedded Smart Cameras Human Detection using Mobile Embedded Smart Cameras

—Embedded smart cameras are stand-alone units that combine sensing and processing on a single embedded platform. They allow ﬂexibility in camera placement, and provide mobility without being dependent on wired links. On the other hand, detecting and tracking objects from videos captured by mobile cameras is a very challenging task even on powerful computers. Since embedded smart cameras have very limited processing power, memory and energy, the challenge becomes even bigger. In this paper, we present a person detection system using an embedded smart camera mounted on a remote-controlled car. We employ histogram of oriented gradients (HOG) for detection, and present the performance results obtained on these resource- constrained environments. The example application is patrolling hallways in a building to detect people.
BORDERS. Visual analysis of Cinema’s inner dynamics and evolutions. A case study based on the Internet Movie Database

Since the launch of the Internet Movie Database (abbreviated IMDb), in 1990, a large amount of data about movies has been collected online, giving us the possibility to analyse the film industry on a large scale. This paper describes the design and some results of ‘Borders. A geo-political atlas of film’s production’, a project that aims at visually represent and exploring the multi-dimensional and heterogeneous data coming from this online archive. The main goal is to visually analyse the relationships between geo-political regions and countries, using the data related to the film industry as a privileged point of view.
Effect of High-Dose Antimicrobials on Bioﬁlm Growth of Achromobacter Species Isolated from Cystic Fibrosis Patients

MICs and bioﬁlm inhibitory concentrations (BICs) were measured for 68 cystic ﬁbrosis (CF) Achromobacter isolates for amikacin, aztreonam, colistin, levoﬂoxacin, and tobramycin. With the exception of colistin and levoﬂoxacin, the remaining antibiotics had MIC 90 s, BICs at which 50% of the isolates were susceptible (BIC 50 s), and BICs at which 90% of the isolates were susceptible (BIC 90 s) equal to or above the highest concentrations tested. In a bioﬁlm model, tobramycin was able to signiﬁcantly increase killing of bacterial cells compared to controls, for intermediate-resistant strains only, at concentrations of 1,000 and 2,000 (cid:2) g/ml.