Miracle-dz/UniFAR-FTUs huggingface dataset:
Level of Overweight, Obesity and Associated Factors Among Preschool Children in Dire Dawa City, Eastern Ethiopia, 2016

Background : Obesity is accumulation of excess fat that have negative consequences on health. In 21 st century overweight and obesity of children is becoming burning issue. About 42 million under five children are overweight and obese in 2013. Close to 31 million of these are living in developing countries. The objective of this study was to assess the level of overweight and obesity and associated factors among preschool children aged 3-5years in Dire Dawa city, Ethiopia, 2016. Methodology: A community based cross sectional study design was used from March 1-15 2016. Simple random sampling followed by systematic random sampling technique was used to select study participants. A pretested structured questionnaire was used to collect data from total samples of 627 preschool age children with their respective mothers or caretakers. Weight and height were measured using standardized and calibrated equipment. Finally Binary logistic regression analysis was done to identify factors associated with overweight and obesity. Level of statistical significance was declared at p- value less than 0.05. Results : The magnitude of overweight and obesity in the study area were 11.4% and 5.5% respectively. Female sex (AOR = 2.67, 95% CI: 1.13 - 6.32), Mother BMI (AOR = 16.5, 95% CI: 6.80 - 40.29, p value < 0.001) and Father Education (AOR =7.179, 95% CI: 1.06-48.6, p value <0.05) were among factors associated with preschool children overweight and obesity. Conclusion and Recommendation : The combined prevalence of overweight and obesity seen in this city is 16.9%. So as Government of Ethiopia continues in its ﬁght towards reducing under nutrition, it should also expand or modify these efforts to include ways that may help prevent and reduce prevalence of overweight within the community. Keywords: Overweight, Obesity, preschool children, Dire Dawa, Ethiopia. DOI : 10.7176/JMPB/52-06
Object Recognition with SIFT and MI-SIFT Methods

This study, which has been commonly used in object recognition area for 10 years, is based on the recognition of special point-based objects and there are differences in some areas such as luminance, anguler and resistance from cyclic and dimensional changes. Generally, scalar invariant feature transformation (scale invariant feature transform- SIFT) method and independent feature transformation (mirror reflection invariant feature- MIFT) method which is a weak point of SIFT method, also is created against the mirroring effect to gain resistance are investigated in this experiment. In this work, 11 sample trials with images which were in different cases were performed one by one to analyze these methods actually and this could give us opportunity to compare the results of the methods respectively. The aim of this work was understanding the performance capability of object recognition methods that were SIFT and MIFT in time domain and space domain, also determining the speed and result acquisition time values of these methods represented us to observe the advantages and disadvantages of SIFT and MIFT.
Scalelengths in Dark Matter Halos

We investigate a hypothesis regarding the origin of the scalelength in halos formed in cosmological N-body simulations. This hypothesis can be viewed as an extension of an earlier idea put forth by Merritt and Aguilar. Our findings suggest that a phenomenon related to the radial orbit instability is present in such halos and is responsible for density profile shapes. This instability sets a scalelength at which the velocity dispersion distribution changes rapidly from isotropic to radially anisotropic. This scalelength is reflected in the density distribution as the radius at which the density profile changes slope. We have tested the idea that radially dependent velocity dispersion anisotropy leads to a break in density profile shape by manipulating the input of a semi-analytic model to imitate the velocity structure imposed by the radial orbit instability. Without such manipulation, halos formed are approximated by single power-law density profiles and isotropic velocity distributions. Halos formed with altered inputs display density distributions featuring scalelengths and anisotropy profiles similar to those seen in cosmological N-body simulations. Subject headings: dark matter — galaxies:formation, evolution
Extracellular matrix compression temporally regulates microvascular angiogenesis

Extracellular matrix deformation temporally regulates angiogenesis and upstream angiogenic and mechanosensitive pathways. Mechanical cues influence tissue regeneration, and although vasculature is known to be mechanically sensitive, little is known about the effects of bulk extracellular matrix deformation on the nascent vessel networks found in healing tissues. Previously, we found that dynamic matrix compression in vivo potently regulated revascularization during bone tissue regeneration; however, whether matrix deformations directly regulate angiogenesis remained unknown. Here, we demonstrated that load initiation time, magnitude, and mode all regulate microvascular growth, as well as upstream angiogenic and mechanotransduction signaling pathways. Immediate load initiation inhibited angiogenesis and expression of early sprout tip cell selection genes, while delayed loading enhanced microvascular network formation and upstream signaling pathways. This research provides foundational understanding of how extracellular matrix mechanics regulate angiogenesis and has critical implications for clinical translation of new regenerative medicine therapies and physical rehabilitation strategies designed to enhance revascularization during tissue regeneration.
Social reprogramming in ants induces longevity-associated glia remodeling

Single-cell RNA-seq reveals increased numbers of ensheathing glia in Harpegnathos workers reprogrammed to a queen-like phenotype. In social insects, workers and queens arise from the same genome but display profound differences in behavior and longevity. In Harpegnathos saltator ants, adult workers can transition to a queen-like state called gamergate, which results in reprogramming of social behavior and life-span extension. Using single-cell RNA sequencing, we compared the distribution of neuronal and glial populations before and after the social transition. We found that the conversion of workers into gamergates resulted in the expansion of neuroprotective ensheathing glia. Brain injury assays revealed that activation of the damage response gene Mmp1 was weaker in old workers, where the relative frequency of ensheathing glia also declined. On the other hand, long-lived gamergates retained a larger fraction of ensheathing glia and the ability to mount a strong Mmp1 response to brain injury into old age. We also observed molecular and cellular changes suggestive of age-associated decline in ensheathing glia in Drosophila.
Characterization of Genomic MidRange Inhomogeneity

Background. Genomes possess different levels of non­randomness, in particular, an inhomogeneity in their nucleotide composition. Inhomogeneity is manifest from the short­ range where neighboring nucleotides influence the choice of base at a site, to the long­ range, commonly known as isochores, where a particular base composition can span millions of nucleotides. A separate genomic issue that has yet to be thoroughly elucidated is the role that RNA secondary structure (SS) plays in gene expression. Results. We present novel data and approaches that show that a mid­range inhomogeneity (~30 to 1000 nt) not only exists in mammalian genomes but is also significantly associated with strong RNA SS. A whole­genome bioinformatics investigation of local SS in a set of 11,315 non­redundant human pre­mRNA sequences has been carried out. Four distinct components of these molecules (5 ­UTRs, exons, introns and 3 ­UTRs) were considered separately, since they differ in overall nucleotide composition, sequence motifs and periodicities. For each pre­mRNA component, the abundance of strong local SS (< ­25 kcal/mol) was a factor of two to ten greater than a random expectation model. The randomization process preserves the short­range inhomogeneity of the corresponding natural sequences, thus, eliminating short­range signals as possible contributors to any observed phenomena.
Functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing

Biodegradable nanomaterials effectively deliver long messenger RNAs in animal models. Messenger RNA (mRNA) therapeutics have been explored to treat various genetic disorders. Lipid-derived nanomaterials are currently one of the most promising biomaterials that mediate effective mRNA delivery. However, efficiency and safety of this nanomaterial-based mRNA delivery remains a challenge for clinical applications. Here, we constructed a series of lipid-like nanomaterials (LLNs), named functionalized TT derivatives (FTT), for mRNA-based therapeutic applications in vivo. After screenings on the materials, we identified FTT5 as a lead material for efficient delivery of long mRNAs, such as human factor VIII (hFVIII) mRNA (~4.5 kb) for expression of hFVIII protein in hemophilia A mice. Moreover, FTT5 LLNs demonstrated high percentage of base editing on PCSK9 in vivo at a low dose of base editor mRNA (~5.5 kb) and single guide RNA. Consequently, FTT nanomaterials merit further development for mRNA-based therapy.
Massively parallel single-molecule telomere length measurement with digital real-time PCR

Digital real-time PCR assay rapidly measures single telomere lengths and uncovers telomere maintenance mechanisms in cancer. Telomere length is a promising biomarker for age-associated diseases and cancer, but there are still substantial challenges to routine telomere analysis in clinics because of the lack of a simple and rapid yet scalable method for measurement. We developed the single telomere absolute-length rapid (STAR) assay, a novel high-throughput digital real-time PCR approach for rapidly measuring the absolute lengths and quantities of individual telomere molecules. We show that this technique provides the accuracy and sensitivity to uncover associations between telomere length distribution and telomere maintenance mechanisms in cancer cell lines and primary tumors. The results indicate that the STAR assay is a powerful tool to enable the use of telomere length distribution as a biomarker in disease and population-wide studies.
The Neural Basis of Metaphor Comprehension: Evidence from Left Hemisphere Degeneration

Abstract Despite the ubiquity of metaphor in cognition and communication, it is absent from standard clinical assessments of language, and the neural systems that support metaphor processing are debated. Previous research shows that patients with focal brain lesions can display selective impairments in processing metaphor, suggesting that figurative language abilities may be disproportionately vulnerable to brain injury. We hypothesized that metaphor processing is especially vulnerable to neurodegenerative disease, and that the left hemisphere is critical for normal metaphor processing. To evaluate these hypotheses, we tested metaphor comprehension in patients with left-hemisphere neurodegeneration, and in demographically matched healthy comparison participants. Stimuli consisted of moderately familiar metaphors and closely matched literal sentences sharing the same source term (e.g., The interview was a painful crawl / The infant’s motion was a crawl). Written sentences were presented, followed by four modifier-noun answer choices (one target and three foils). Healthy controls, though reliably better at literal than metaphor trials, comprehended both sentence conditions well. By contrast, participants with left-hemisphere neurodegeneration performed disproportionately poorly on metaphor comprehension. Anatomical analyses show relationships between metaphor accuracy and patient atrophy in the left middle and superior temporal gyri, and the left inferior frontal gyrus, areas that have been implicated in supporting metaphor comprehension in previous imaging research. The behavioral results also suggest deficits of metaphor comprehension may be a sensitive measure of cognitive dysfunction in some forms of neurodegenerative disease.
Schedule Synthesis for Halide Pipelines on GPUs

The Halide DSL and compiler have enabled high-performance code generation for image processing pipelines targeting heterogeneous architectures through the separation of algorithmic description and optimization schedule. However, automatic schedule generation is currently only possible for multi-core CPU architectures. As a result, expert knowledge is still required when optimizing for platforms with GPU capabilities. In this work, we extend the current Halide Autoscheduler with novel optimization passes to efficiently generate schedules for CUDA-based GPU architectures. We evaluate our proposed method across a variety of applications and show that it can achieve performance competitive with that of manually tuned Halide schedules, or in many cases even better performance. Experimental results show that our schedules are on average 10% faster than manual schedules and over 2× faster than previous autoscheduling attempts.
Training Inhibition and Social Cognition in the Classrooms

Executive functions and social cognition competences are associated with many important areas of life, such as school readiness, academic success or sociability. Numerous intervention programs aiming to improve these capacities have emerged and have been shown to be effective. As inhibition in particular, is closely related with social cognition competences, we developed a training program that targets both abilities and implemented it in kindergarten and lower primary school classes for 6 months. We evaluated its effectiveness at improving inhibition and social cognition as well as its possible impact on academic performance. The results showed that tackling inhibition and social cognition in the classroom at an early age improved inhibition, visual attention and flexibility as well as Theory of Mind and social information processing skills. However, the impact on academic learning was weak; a slight effect on a mathematical task was observed.
Changes in Empathy in Patients With Chronic Low Back Pain: A Structural–Functional Magnetic Resonance Imaging Study

Objective: Many pieces of research have focused on pain within individuals, but little attention has been paid to whether pain can change an individual’s empathic ability and affect social relationships. The purpose of this study is to explore how chronic low back pain changes empathy. Methods: Twenty-four chronic low back pain patients and 22 healthy controls were recruited. We set up an experimental pain-exposed model for each healthy subject. All subjects received a painful-empathic magnetic resonance scan. After the scan, all subjects rated the pain intensity and multiple empathy-related indicators. The clinical assessment scale was the 20-item Basic Empathy Scale in Adults. Result: The chronic low back pain patients reported lower scores on the total scores of BES-A, the subscale scores of emotional disconnection and cognitive empathy, and the discomfort rating. The fMRI results in the chronic low back pain patients showed that there were multiple abnormal brain pathways centered on the anterior insula. The DTI results in the chronic low back pain patients showed that there were reduced fractional anisotropy values in the corpus callosum, bilateral anterior thalamic radiation (ATR), right posterior thalamic radiation (PTR), right superior longitudinal fasciculus (SLF), and left anterior corona radiate (ACR). Conclusion: Our study found that patients with chronic low back pain have impaired empathy ability. The abnormal functional connectivity of multiple brain networks, multiple damaged white matter tracts, and the lower behavioral scores in chronic low back pain patients supported our findings.
Remote Microphone Hearing Aid Use Improves Classroom Listening, Without Adverse Effects on Spatial Listening and Attention Skills, in Children With Auditory Processing Disorder: A Randomised Controlled Trial

Background Children with Auditory Processing Disorder (APD) often have poor auditory processing skills in the presence of normal peripheral hearing. These children have worse listening-in-noise skills compared to typically developing peers, while other commonly reported symptoms include poor attention and distractibility. One of the management strategies for children with APD is the use of Remote Microphone Hearing Aids (RMHAs), which can help improve the signal-to-noise ratio in the child’s ears. The aim of this randomised controlled trial was to examine whether RMHAs improved classroom listening in children with APD, and to further test their effects on children’s listening-in-noise and attention skills following a 6-month intervention. Methods Twenty-six children diagnosed with APD, aged 7–12, in primary mainstream education, were randomised into the intervention (N = 13) and control group (N = 13). The primary outcome measure was the Listening Inventory for Education – Revised questionnaire, completed by children to assess their listening using RMHAs under several acoustically challenging situations in the classroom. Secondary outcome measures included the Listening in Spatialised Noise – Sentences test, assessing speech-in-noise perception and spatial listening, and the Test of Everyday Attention for Children, assessing different types of attention skills. Tests were conducted in unaided conditions. Mixed analysis of variance was used to analyse the data. The clinical trial was registered at clinicaltrials.gov (unique identifier: NCT02353091). Results The questionnaire scores of self-reported listening skills in the classroom significantly improved in the intervention group after 3, MD = 7.31, SE = 2.113, p = 0.014, and after 6 months, M = 5.00, SE = 1.468, p = 0.016. The behavioural measures of listening-in-noise and attention did not significantly change. Conclusion Use of RMHAs improves classroom listening, evidenced by the results of the questionnaire analysis, while a 6-month use did not have adverse effects on unaided spatial listening or attention skills.
Effect of Vitamin D Supplementation on Bone Mineral Density in Rheumatoid Arthritis Patients With Osteoporosis

Objectives: To assess the effect of vitamin D supplementation on bone mineral density (BMD) in rheumatoid arthritis (RA) patients with osteoporosis and determine whether supplementation of more than 800 IU/day, which is the currently recommended dose, is beneficial. Methods: RA patients with osteoporosis who received bisphosphonate were included. Patients were classified into four groups according to the dose of vitamin D supplementation (0, 400, 800, and ≥1,000 IU/day). Multivariable linear regression models were performed to evaluate the effect of each dose of vitamin D supplementation on 1-year% change of BMD. Results: In total, 187 RA patients with osteoporosis were included. In the multivariate model adjusted for potential confounders, patients receiving vitamin D supplementation had a significantly higher increase in 1-year % change in lumbar spine BMD (400 IU/day: β = 2.51 [95% CI: 0.04–4.99], 800 IU/day: β = 2.90 [95% CI: 0.47–5.33], and ≥1,000 IU/day: β = 6.01 [95% CI: 3.71–8.32]) and femoral neck BMD (400 IU/day: β = 3.88 [95% CI: 1.83–5.94], 800 IU/day: β =4.30 [95% CI: 2.25–6.35], and ≥1,000 IU/day: β = 6.79 [95% CI: 4.87–8.71]) than those not receiving the supplementation. Notably, the ≥1,000-IU/day group had a significantly higher increase in 1-year % change in lumbar spine BMD (β = 3.11 [95% CI: 0.86–5.37]) and femoral neck BMD (β = 2.50 [95% CI: 0.63–4.36]) than the 800-IU/day group. Conclusion: In RA patients with osteoporosis receiving bisphosphonates, vitamin D supplementation was associated with a higher increase in BMD. This effect was higher in the vitamin D supplementation dose of ≥1,000 IU/day than in 800 IU/day.
Effects of Bifidobacterium longum Subsp. infantis CECT 7210 and Lactobacillus rhamnosus HN001, Combined or Not With Oligofructose-Enriched Inulin, on Weaned Pigs Orally Challenged With Salmonella Typhimurium

Salmonella is a common causative agent of enteric disease and is developing mechanisms of resistance to antimicrobials. Probiotics, such as bifidobacteria and lactobacilli, and prebiotic fibers are a potential alternative to counteract this pathogen as they have demonstrated effectiveness in preventing its adhesion, reducing intestinal damage, and enhancing the host immune system. Furthermore, the benefits are expected to be potentiated when these compounds are administered together. A trial was performed to evaluate the efficacy of two probiotic strains (Bifidobacterium longum subsp. infantis CECT 7210 (Laboratorios Ordesa S.L.) and Lactobacillus rhamnosus HN001, combined or not with a prebiotic containing oligofructose-enriched inulin, against Salmonella Typhimurium. Ninety-six piglets (28 days old) were distributed into 32 pens assigned to 5 treatments: one non-challenged (control diet, CTR+) and four challenged: control diet (CTR−) or supplemented with probiotics (>3 × 1010 cfu/kg each strain, PRO), prebiotic (5%, PRE), or their combination (SYN). After 1 week of adaptation, animals were orally challenged with Salmonella Typhimurium. Feed intake, weight, and clinical signs were recorded. On days 4 and 8 post-inoculation (PI), one animal per pen was euthanized, and samples from blood, digestive content, and ileal tissues were collected to determine Salmonella counts, fermentation products, ileal histomorphology, and serum TNF-α and Pig-MAP concentrations. The effect of the oral challenge was evidenced by animal performance, fecal consistency, and intestinal architecture. Regarding the experimental treatments, animals belonging to the PRO group experienced a faster clearance of the pathogen, with more pigs being negative to its excretion at the end of the study and recovering the impaired ileal villi/crypt ratio more rapidly. Animals receiving the PRE diet showed a lower intestinal colonization by Salmonella, with no countable levels (<3 cfu/g) in any of the analyzed samples, and an augmented immune response suggested by serum Pig-MAP concentrations. Treatments including the prebiotic (PRE and SYN) showed similar changes in the fermentation pattern, with an increase in the molar percentage of valeric acid concentration in the colon. The SYN group, however, did not show any of the outcomes registered for PRO and PRE in Salmonella colonization or in immunity markers, suggesting the lack of synbiotic action in this animal model. Further research is needed to better understand the complex mechanisms behind these effects.
Interference of Horsenettle (Solanum carolinense) with Peanuts (Arachis hypogaea)

Duration and density experiments were conducted in the field to measure horsenettle (Solanum carolinense L. # SOLCA) interference with Spanish and runner-type peanuts (Arachis hypogaea L. ‘Pronto’ and ‘Florunner′). Spanish peanut yield generally was higher with 6 to 8 weeks of weed-free maintenance. Horsenettle interference for 6 to 8 weeks did not decrease the yield of Spanish peanuts, and interference for 6 weeks did not decrease yields of runner peanuts. Weed-free maintenance for 2 or more weeks allowed increased runner peanut yield when compared to weedy plots. Linear regression predicted a 69 kg/ha Spanish peanut yield increase for each week of weed-free maintenance. Linear regression predicted a Spanish peanut yield reduction of 40 kg/ha for each week of weed interference in 1983, the only year in which the slopes of the regressions were statistically significant Curvilinear equations with the runner-type cultivar predicted an 81 kg/ha yield increase or 96 kg/ha decrease for each week of weed-free maintenance or weed interference, respectively. In 1 of 2 yr, Spanish peanut yield was reduced by horsenettle at a density of 32 plants/10 m of row.