Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of aerobic workout on the changes in the characteristics of dynamics of the center of gravity in different age categories.

INTRODUCTION The quality and function of movements undergo deterioration due to weight gain. Aerobic training normalizes body weight, improves the health status, and in addition, it is expected to improve the dynamics of movements. The aims of this study were to prove the beneficial effects of recreational physical activities on the movements. METHODS Participants were divided into five different age categories: second childhood, adolescence, mature age I, mature age II, and aging. Squatting and vertical jumping of the participants were measured at the beginning and at the end of a 5-month training program. These movements simulated ordinary daily movements. Changes in the body were determined by InBody230. APAS 3D system was used for movement analysis. RESULTS The results showed significant improvements in body weight, fat mass, muscle mass, fat mass-body weight ratio, muscle mass-body weight ratio, body mass index, body fat percentage, and waist-hip ratio. During jumping, the lifting and sinking of the center of gravity's (CG) position and its velocity and acceleration were improved. In case of squatting, the results showed significant improvements in the velocity and acceleration of dynamical characteristics of the CG. Other correlations were observed between changes in body composition and the dynamics of movements. DISCUSSION The research proved that recreational training optimized body composition and improved the characteristics of CG's dynamics. The study suggests considerable connection between body composition and the characteristics of the movements' dynamics. From this point of view, our training program was the most effective in the working age groups.
Renal insufficiency following contrast media administration trial III: Urine flow rate‐guided versus left‐ventricular end‐diastolic pressure‐guided hydration in high‐risk patients for contrast‐induced acute kidney injury. Rationale and design

Urine flow rate (UFR)‐guided and left‐ventricular end‐diastolic pressure (LVEDP)‐guided hydration regimens have been proposed to prevent contrast‐induced acute kidney injury (CIAKI). The REnal Insufficiency Following Contrast MEDIA Administration triaL III (REMEDIAL III) is a randomized, multicenter, investigator‐sponsored trial aiming to compare these two hydration strategies.
RETRACTED ARTICLE: Up-regulated lncRNA GAS5 promotes chemosensitivity and apoptosis of triple-negative breast cancer cells

Statement of Retraction We, the Editors and Publisher of the journal Cell Cycle, have retracted the following article: Juntao Li, Lin Li, Huozhong Yuan, Xing-Wei Huang, Tianxin Xiang and Sujuan Dai. Up-regulated lncRNA GAS5 promotes chemosensitivity and apoptosis of triple-negative breast cancer cells. Cell Cycle. 2019;18(16):1965-1975. doi: 10.1080/15384101.2019. 1635870 Since publication, significant concerns have been raised about the integrity of the data and reported results in the article. When approached for an explanation, the authors did not provide their original data or any necessary supporting information. As verifying the validity of published work is core to the integrity of the scholarly record, we are therefore retracting the article. The corresponding author listed in this publication has been informed. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as ‘Retracted’.
Bleomycin, vinblastine and dacarbazine combined with nonpegylated liposomal doxorubicin (MBVD) in elderly (≥70 years) or cardiopathic patients with Hodgkin lymphoma: a phase-II study from Fondazione Italiana Linfomi (FIL)

Abstract This phase-II study assessed activity and toxicity of substituting conventional doxorubicin with nonpegylated liposomal doxorubicin in the conventional ABVD regimen for the treatment of elderly or cardiopathic patients with HL. Stage I–IIA and IIB–IV patients were treated with three courses of MBVD plus radiotherapy, or six courses of MBVD, respectively, plus radiotherapy limited to bulky or residual disease areas. The primary endpoints were CR rate and the rate of cardiac events. Forty-seven patients were enrolled. Median age was 75 years, 13 had stage I–II disease. Overall, CR was achieved by 36 patients (77%, 95% CI: 62–88), 100% and 68% in stage I–II and III–IV, respectively. With a median follow-up of 40 months (IQR: 36–45). Three-year overall survival (OS) and progression-free survival (PFS) were 70% and 43%, respectively. Cardiac events grades 3–5 were reported in two patients. In conclusion, MBVD’s activity and safety profile was comparable to historical ABVD data.
Growing Roots: A Newcomer Nutrition Program Designed Using Action Research Methods

ABSTRACT Many newcomers to Canada struggle with food insecurity and the health impacts of dietary acculturation. “Growing Roots” is a newcomer nutrition program designed through a community development approach to help immigrants and refugees adapt positively to the Canadian food environment. This qualitative action research project documented the development, implementation and impacts of the program in an inner city neighbourhood of Winnipeg, Manitoba, Canada. Data was collected through oral questionnaires and interviews. Impacts included: 1) Healthy adaptation to the Canadian foodscape; 2) Enhanced nutrition knowledge and behaviours; 3) Improvements to food security status; and 4) Enhanced social networks.
Limbal Epithelial and Mesenchymal Stem Cell Therapy for Corneal Regeneration

ABSTRACT Corneal pathologies are a major cause of blindness and visual impairment, especially in the developing world. However, not only is there a global shortage of donor corneal tissue, but a significant proportion of these blinding pathologies also carry an unfavourable long-term prognosis for conventional corneal transplantation. In the last few decades, there has been a spurt of research on developing alternate approaches to address corneal blindness, including stem cell therapy. After the discovery of epithelial stem cells at the limbus, successful cell-based approaches to treat severe ocular surface disease were developed and have subsequently become widely practised across the world. More recently, mesenchymal stem cells were identified near the epithelial stem cells at the limbus, providing a unique opportunity to develop regenerative therapies for both corneal epithelial and stromal pathologies. This review firstly emphasises on qualifying limbal stem cells as either epithelial or mesenchymal and then summarises all the existing knowledge on both cell types and their individual roles in corneal regeneration. The review describes the history, indications, techniques, and outcomes of the different methods of limbal epithelial stem cell transplantation and elaborates on the potential applications of limbal mesenchymal stem cell therapy.
How 'to Be Like' a Kiwi: Verbs of Quotation in New Zealand English

A study examines the use of verbs of quotation among speakers of New Zealand English in 2000, and compares them to patterns of use as recorded from studies in 1995 and 1996. Results reveal that an American pattern in the use of quotative verbs is increasingly being used by young New Zealand English speakers.
A simple checking algorithm with perturb and observe maximum power point tracking for partially shaded photovoltaic system

This paper presents a simple checking algorithm for maximum power point tracking (MPPT) technique for Photovoltaic (PV) system using Perturb and Observe (PO or in other words partially shaded condition of PV array. The results from the system using the proposed approach prove to have faster response and low ripple. Besides, the results are close to the desired outputs and exhibit an approximately 98.25% of the system efficiency. On the other hand, the system with conventional P&O MPPT seems to be unstable and has higher percentage of error. In summary, the proposed method is useful under varying level of irradiation with higher efficiency of the system.
Terpinen-4-ol and carvacrol affect multi-species biofilm composition

Abstract The aim of this study was to investigate the cytotoxic activity and inhibitory effect of terpinen-4-ol (T4ol) and carvacrol against single- and multi-species biofilms. The toxicity of each compound was tested on oral keratinocytes and evaluated by XTT assay. Inhibition and eradication of single-species biofilms were analyzed by crystal violet assay and the effect on multi-species biofilm composition was evaluated by qPCR. T4ol and carvacrol did not affect the epithelial cell viability, in contrast to chlorhexidine, which showed a high cytotoxic effect. Inhibition and eradication of single-species biofilms treated with T4ol and carvacrol were observed. The same inhibitory effect was observed for multi-species biofilms, especially on periodontal pathogens. In conclusion, specific concentrations of T4ol and carvacrol without toxicity towards the epithelial cells reduced the numbers of periodontal pathogens in single- and multi-species biofilms.
Foliar water-uptake strategies are related to leaf water status and gas exchange in plants from a ferruginous rupestrian field.

PREMISE Fog is a frequent event in Brazilian rupestrian field and plays an important role in the physiology of several plant species. Foliar water uptake (FWU) of fog may be fast or slow depending on the species. However, fog water may negatively affect CO2 assimilation. Thus, the interference in the water and carbon balance as a result of different strategies of FWU was evaluated to verify whether fog may mitigate possible water deficit in leaves. METHODS Four plant species with different FWU strategies were studied in a ferruginous rupestrian field with frequent fog. Gas exchange and water potential were measured before dawn and at midday during the dry and rainy seasons, separating foggy from non-foggy days during the dry season. RESULTS The FWU speed negatively influences CO2 assimilation in the dry season, possibly because of its negative relationship with stomatal conductance, since reduced stomatal aperture impairs carbon entrance. Fog presence increased leaf water potential both in early morning and midday during the dry season. However, during the rainy season, the values of leaf water potential were lower at midday, than during the dry season with fog at midday, which favors leaf gas exchanges. CONCLUSIONS FWU interferes negatively, but briefly with CO2 assimilation. Nevertheless, FWU prevents water loss through transpiration and increases the water status of plants in the dry season. That is, FWU results in a compensation between CO2 assimilation and foliar hydration, which, in fact, is beneficial to the plants of this ecosystem.
Olea europaea L. Flowers as a new promising anticancer natural product: phenolic composition, antiproliferative activity and apoptosis induction

Abstract The aim of this study was to characterise phenolic compounds of olive flower obtained from Olive tree cultivar Chemlali and to investigate their anticancer effect on MCF-7 cells. Phenolic characterisation was determined using LC/MS-MS. Cytotoxicity of the extract was determined using MTT. Biochemical markers of apoptosis were evaluated by immunoblotting. Our results showed that olive flower contained significant amounts of phenolic compounds mainly flavonoids, secoiridoids and simple phenols. Furthermore, the phenolic extract exerted a significant reduction in MCF-7 cell viability (EC50 values equal to 220.8 μg/ml). Western blot analysis revealed the presence of the cleaved forms of Parp-1. The DAPI staining analysis demonstrated a significant reduction in the number of cells and a considerable change in the morphology of the treated cells. In conclusion, Olea europaea. L flower contained great amounts of different bio-phenols able to reduce the proliferative activity of breast cancer MCF-7 cells by the induction of apoptosis. Graphical Abstract
Performance Comparison of Message Passing and Shared Memory Programming with HPC Benchmarks

Research has been carried out into the performance of Shared Memory programming and Message Passing programming using the Java Grande Benchmark Suite. Java benchmarks parallelised using hpJava and Java Threads were examined and used to aid the parallelisation of serial C code using OpenMP and MPI. Performance of the parallel C and Java benchmarks was tested on three different High Performance Computing systems. Analysis of the performance results found that each model has strengths and weaknesses. Performance of each model varies, dependent upon the application being parallelised, the language being used to write the application, and the hardware system being used to run the application. In some situations, Shared Memory programming provides best performance, in others best performance is gained using Message Passing programming. Analysis of language performance shows that while Java can sometimes match the performance of C, in general it is slower.
Mucilage-bound sand reduces seed predation by ants but not by reducing apparency: a field test of 53 plant species.

Seed mucilage - a coating on seeds or fruit which becomes slimy and sticky when wet - has evolved convergently many times across plants. One common consequence of having seed mucilage is that sand and dirt particles stick to wet seeds and remain tightly bound to the seed surface after the mucilage dries. Here, we test the hypothesis that a mucilage-bound sand coating protects the seed from seed predators; either as a physical barrier or by reducing apparency of the seed (i.e. camouflage). We experimentally manipulated the sand coating on seeds of 53 plant species of 13 families and assayed the defensive benefit of the sand coating in feeding "depots" near harvester ant nests in California's Central Valley. Consistent with a defensive function, sand coating reduced ant predation on seeds in 48 of the 53 species examined. To test whether this striking benefit was due to reduced apparency, we conducted an addition experiment using flax seeds in which we factorially manipulated the color of both the background substrate and the sand coating, creating visually apparent and unapparent seeds. Our results did not support the reduced apparency hypothesis; seeds coated in background-matched sand were removed at the same rate as seeds coated in un-matched sand. The defensive benefit of a sand coating was not well-predicted by seed mass, entrapped sand mass, or sand mass scaled by seed mass. Together, our results demonstrate that seed mucilage is a phylogenetically widespread and effective seed defensive trait and point to the physical barrier, not reduced apparency, as a mechanism. This article is protected by copyright. All rights reserved.
A Randomized, Placebo-Controlled, Pilot Clinical Trial of Dipyridamole to Decrease Hiv-Associated Chronic Inflammation.

BACKGROUND Adenosine is a potent immunoregulatory nucleoside produced during inflammatory states to limit tissue damage. We hypothesized that dipyridamole, which inhibits cellular adenosine uptake, could raise the extracellular adenosine concentration and dampen chronic HIV-1 associated inflammation. METHODS Virally-suppressed participants on antiretroviral therapy were randomized 1:1 for 12 weeks of dipyridamole 100mg 4x/day vs placebo capsules. All participants took open-label dipyridamole during weeks 12 to 24. Study endpoints included changes in systemic inflammation [soluble (s) CD163, sCD14, and interleukin-6] and levels of T cell immune activation (HLA-DR+CD38+). RESULTS Forty participants were randomized: 17 dipyridamole and 18 placebo recipients had baseline and week 12 data available for analyses. There were no significant changes in soluble markers apart from a trend towards decreased sCD163 levels (p=0.087). There was a modest decrease in CD8+ T cell activation (-17.53% vs 13.31% change; p=0.032), but the significance was lost in the pooled analyses (p=0.058). Dipyridamole also reduced CD4+ T cell activation (-11.11% change; p=0.006) in the pooled analyses. In post-hoc analysis, detectable plasma DP levels were associated with higher levels of inosine, an adenosine surrogate, and of cyclic adenosine monophosphate. CONCLUSION Dipyridamole increased extracellular adenosine levels and decreased T cell activation significantly among persons with HIV-1 infection on virally-suppressive therapy.
Implementation of a Community-Based Exercise Program for Parkinson Patients: Using Boxing as an Example

Background: Persons with Parkinson’s disease (PD) benefit from continuous exercise through participation in community-based exercise programs. However, community programs often lack PD-specific knowledge needed to provide safe and adequately dosed exercise. Objective: To evaluate the acceptability and safety of a PD-specific boxing program in the community. Methods: We developed specific educational resources to facilitate the boxing instructors. We also organized an educational and practical workshop for patients (n = 26) and instructors (n = 10), and assessed: (a) participants’ satisfaction; (b) instructors’ appreciation of the educational resources; and (c) numbers of patients interested in participating in the boxing program. After 18 months, patients and instructors completed a questionnaire evaluating: (a) participants’ satisfaction; (b) adverse events; (c) facilitators and barriers; and (d) proportion of participants at follow-up. Results: Twenty-six persons with PD (62% men) and 10 boxing instructors participated in the workshop. 81% of patients and 80% of instructors were very satisfied. Instructors found the educational materials “very helpful” (60%) or “helpful” (40%). Patients expressed a clear interest (54%) or possible interest (46%) in the program. We initiated classes with 10 participants. At 18-months follow-up, the program consisted of four boxing sessions/week, led by three instructors, with 40 participants. Seventeen patients responded to the questionnaire at follow-up. Participants were “very satisfied” (53%), “satisfied” (35%) and neither satisfied nor unsatisfied (12%) with the program. Adverse effects were mild (e.g., muscle aches). Transportation and physical disability were the main barriers for participation. Conclusions: The boxing program was well-received, with increasing numbers of participants at 18 months. The educational resources can support boxing instructors participating in current and future boxing classes being delivered in the community.
The Relationship Between Depression Symptoms and Anxiety Symptoms During Acute ECT for Patients With Major Depressive Disorder

Abstract Background We investigated the efficacy of electroconvulsive therapy in patients with major depressive disorder and concomitant anxiety symptoms and explored the relationships between depression symptoms and anxiety symptoms during acute electroconvulsive therapy. Methods Major depressive disorder inpatients (N = 130) requiring electroconvulsive therapy were recruited for a maximum of 12 treatments each. Depression symptoms, using the core factor subscale derived from the 17-item Hamilton Depression Rating Scale, and anxiety symptoms, using the anxiety/somatization subscale from the Hamilton Depression Rating Scale-17, were assessed before electroconvulsive therapy, after every 3 electroconvulsive therapy treatments, and after the final electroconvulsive therapy. Both core factor subscale and anxiety/somatization subscale scores were converted to T-score units to compare the degrees of changes between depression symptoms and anxiety symptoms after electroconvulsive therapy. The relationships between core factor subscale and anxiety/somatization subscale were analyzed using the cross-lagged longitudinal model during acute electroconvulsive therapy. Results A total 116 patients who completed at least the first 3 electroconvulsive therapy treatments were included in the analysis. Reduction of core factor scale T-scores was significantly greater than that of anxiety/somatization subscale T-scores. The model satisfied all indices of goodness-of-fit (chi-square = 30.204, df = 24, P = 0.178, Tucker-Lewis Index = 0.976, Comparative Fit Index = 0.989, Root Mean Square Error of Approximation = 0.047). Core factor subscale changes did not definitely predict subsequent anxiety/somatization subscale changes. Conclusions Electroconvulsive therapy is effective in the acute treatment of major depressive disorder patients associated with anxiety symptoms. Anxiety symptoms improved less than depression symptoms during acute electroconvulsive therapy. However, earlier reduction in depression symptoms does not definitely drive subsequent relief in anxiety symptoms.
FRAMES-2.0 Software System: Providing Password Protection and Limited Access to Models and Simulations

One of the most important concerns for regulatory agencies is the concept of reproducibility (i.e., reproducibility means credibility) of an assessment. One aspect of reproducibility deals with tampering of the assessment. In other words, when multiple groups are engaged in an assessment, it is important to lock down the problem that is to be solved and/or to restrict the models that are to be used to solve the problem. The objective of this effort is to provide the U.S. Nuclear Regulatory Commission (NRC) with a means to limit user access to models and to provide a mechanism to constrain the conceptual site models (CSMs) when appropriate. The purpose is to provide the user (i.e., NRC) with the ability to “lock down” the CSM (i.e., picture containing linked icons), restrict access to certain models, or both.
Effect of ‘rice’ pattern on high blood pressure by gender and obesity: using the community-based KoGES cohort

Abstract Objective: The present study aimed to examine the association between dietary pattern and the risk of high blood pressure (BP) and to estimate the attenuated effect by gender and obesity on the association using data from a prospective cohort study in Korea. Design: Prospective study. Diet was assessed using a validated 103-item FFQ and was input into factor analysis after adjustment for total energy intake. Setting: Community-based Korean Genome Epidemiology Study (KoGES) cohort. Participants: Healthy individuals (n 5151) without high BP at recruitment from the community-based cohort study. Results: Dietary pattern was not associated with the risk of high BP regardless of the type of covariates, with the exception of the ‘rice’ pattern. The effect of the ‘rice’ pattern was observed in both men (Ptrend = 0·013) and women (Ptrend < 0·001), but the statistical significance remained only in women after adjustment for confounders (Ptrend = 0·004). The positive association of the ‘rice’ pattern with high BP risk was attenuated by obesity. After stratification by gender and obese status, in particular, the harmful effect of the ‘rice’ pattern was predominantly observed in obese women (Ptrend < 0·001) only. Conclusions: This longitudinal study in Korean adults found a positive association of the ‘rice’ pattern with long-term development of incident high BP, predominantly in women. The association is likely to be attenuated by gender and obese status.