Miracle-dz/UniFAR-FTUs huggingface dataset:
The Double Hazard of Bleeding and Thrombosis in Hemostasis From a Clinical Point of View: A Global Assessment by Rotational Thromboelastometry (ROTEM)

Hemostasis is a complex dynamic process involving bleeding and thrombosis as two end-points. Conventional coagulation tests which are measured in plasma examine only isolated portions of the coagulation cascade, thereby giving no information on important interactions essential to the clinical evaluation of hemostatic function. Thromboelastography (TEG), originally described in 1948 has improved over the decades and become a valuable tool of coagulation testing because of the limitations of standard coagulation tests. TEG is a technique that provides data about the entire coagulation system, from the beginning of clot formation to fibrinolysis, involving both cellular and plasma components of hemostasis. Rotational thromboelastometry (ROTEM) which evolved from TEG technology overcome several limitations of classical TEG while maintaining a good correlation with conventional TEG determination. ROTEM analyses are useful for rapid assessment of global clotting function in various clinical situations including liver transplantation, cardiac surgery, obstetrics, trauma, hemophilia and idiopathic thrombocytopenic purpura. ROTEM has been also reported to be useful in identifying various hypercoagulable conditions including major surgery, malignancy, Behcet’s disease and apheresis. Further developments in ROTEM based transfusion strategies may also reduce transfusion requirements and improve clinical outcomes by optimizing the administration of blood components. This is a literature review of ROTEM including its technique, interpretation and specially clinical applications in different scenarios of bleeding and thrombotic disorders.
The Footprint of Things: A hybrid approach towards the collection, storage and distribution of life cycle inventory data

Life cycle assessment is a well-established methodology for assessing the environmental impacts of products and services. Unfortunately, an essential part of this life cycle assessment method, col- lecting inventory data, is extremely time consuming. The quality of manually conducted LCA studies is often limited by uncertainty in the inventory data or narrow scope. Past attempts to overcome these challenges through automation of data collection utilizing the Internet of Things have relied on fully centralized architectures. The drawback of a central repository is the complex coordination between all involved actors in supply chains of products and services. This paper proposes an alternative hybrid approach combining a primary distributed system supplemented with a central repository reducing the need for coordination. This hybrid approach is named "the Footprint of Things". We present a system design that embeds the automatic reporting of life cycle inventory data, such as energy and material flows, into all product components involved in a service delivery. The major strength of our novel system design, among others, is its capacity for real-time and more precise impact calculation of ICT services.
Results of a Coordinated Specialty Care Program for Early Psychosis and Predictors of Outcomes.

OBJECTIVE This study prospectively evaluated outcomes of OnTrackNY, a statewide coordinated specialty care (CSC) program for treatment of early psychosis in community settings, as well as predictors of outcomes. METHODS The sample included 325 individuals ages 16-30 with recent-onset nonaffective psychosis who were enrolled in OnTrackNY and who had at least one three-month follow-up. Clinicians provided data at baseline and quarterly up to one year. Domains assessed included demographic and clinical characteristics, social and occupational functioning, medications, suicidality and violence, hospitalization, and time to intervention. Primary outcomes included the symptoms, occupational functioning, and social functioning scales of the Global Assessment of Functioning (GAF), as adapted by the U.S. Department of Veterans Affairs Mental Illness Research, Education and Clinical Center; education and employment status; and psychiatric hospitalization rate. RESULTS Education and employment rates increased from 40% to 80% by six months, hospitalization rates decreased from 70% to 10% by three months, and improvement in GAF scores continued for 12 months. Female gender, non-Hispanic white race-ethnicity, and more education at baseline predicted better education and employment status at follow-up. CONCLUSIONS Individuals with early psychosis receiving CSC achieved significant improvements in education and employment and experienced a decrease in hospitalization rate. Demographic variables and baseline education predicted education and employment outcomes. CSC teams should make particular effort to support the occupational goals of individuals at increased risk of not engaging in work or school, including male participants and participants from racial and ethnic minority groups.
The role of pH in the decomposition of organic micropollutants during the heterogeneous photocatalysis process

The study investigated that the change in the pH ranged from 5 to 7 affects the adsorption degree of selected organic micropollutants such as: polycyclic aromatic hydrocarbons (anthracene, benzo[a]pyrene), pharmaceutical compounds (diclofenac) and industrial additives (octylphenol and pentachlorophenol) on the photocatalyst surface (100 mg TiO 2 /dm 3 ). For example, in suspension of pH 5 a 12% reduction in the concentration of octylphenol was noted, while in the suspension of pH 7 the concentration of this compound was reduced by 64%. In the case of anthracene an inverse relationship was observed. The concentration of this micropollutant decreased by 94% for pH 5 and only by 61% for pH 7 suspension. With the commencement of UV irradiation of reaction mixtures a gradual increase in the concentration of micropollutants reduction in aqueous solutions was observed. This indicates the decomposition of compounds as a result of their reaction with highly reactive OH • radicals or other reactive oxygen species generated during the process. For reaction mixtures of pH 7, already in the first 15 minutes, higher degrees of removal of micropollutants ware observed compared to suspension of pH 6. The obtained micropollutants removal degrees exceeded 91% for diclofenac, octylphenol, pentachlorophenol and amounted to 100% for anthracene and benzo(a)pyrene.
Effects of reduced digestible lysine density on myopathies of the Pectoralis major muscles in broiler chickens at 48 and 62 days of age†

ABSTRACT Quantitative control of nutrient intake may decrease the incidence of wooden breast (WB) and white striping (WS) myopathies with some impairment of live performance. Two experiments (Exp) utilizing Yield Plus × Ross 708 male broilers were conducted to determine if a reduction in myopathies may be obtained through a qualitative approach by reducing digestible lysine (dLys) density. All birds received an identical starter diet until 11 d of age. In Exp 1 (63 pens; 22 birds/pen), each pen was then randomly assigned to 1 of the following 7 dietary treatments (TRT) for a 47 d production period. Seven dietary treatments were provided for the grower 1 (G1; 12 to 18 d of age) and grower 2 (G2; 19 to 26 d of age) phases: 1) 100% of primary breeder recommendations for dLys throughout Exp; 2) 85% of TRT 1 dLys for G1; 3) 85% of TRT 1 dLys for G2; 4) 85% of TRT 1 dLys for G1 and G2; 5) 75% of TRT 1 dLys for G1; 6) 75% of TRT 1 dLys for G2; 7) 75% of TRT 1 for G1 and G2. In Exp 2 (24 pens; 30 birds/pen), birds were randomly assigned to 1 of the following 4 dietary TRT (Table 2) during a 61 d production period. Four dietary treatments were provided for the grower (G; 12 to 28 d) and finisher 1 (F1; 29 to 40 d of age) phases: 1) 100% of primary breeder recommendations for dLys 2) 85% of TRT 1 dLys for G; 3) 85% of TRT 1 dLys for F1; 4) 85% of TRT 1 dLys for G and F1; thereafter, birds received common finisher 1 (Exp 1: 27 to 42 d of age), finisher 2 (Exp 2: 41 to 48 d of age) and withdrawal (Exp 1: 43 to 47 d of age; Exp 2: 49 to 61 d of age) diets. Ideal amino acid ratios were not maintained in reduced dLys diets in either Exp. At 48 (Exp 1; 18 birds/pen) and 62 (Exp 2; 30 birds/pen) d of age, selected birds were processed and fillets were visually scored for WB and WS. No differences (P > 0.05) in cumulative live performance responses between TRT 1 and the remaining TRT were observed in either Exp. In Exp 1, the incidence of severe WB (20.8%) and WS (42.3%) at 48 d of age among birds receiving TRT 7 was reduced (P < 0.01) compared with TRT 1 (WB: 36.6%; WS: 64.3%), at the expense of reduced (P = 0.003) breast weights and yield. In Exp 2, the incidence of severe WB (18.8%) and WS (17.8%) at 62 d of age for birds receiving TRT 4 was reduced (P < 0.05) compared with TRT 1 (WB: 39.3%; WS: 38.3%), without any detrimental effects on processing characteristics. These results indicate that altering dietary dLys during critical periods of the growth trajectory may be a viable strategy for reducing the incidence and severity of WB and WS.
Spontaneous repulsion in the A+B→0 reaction on coupled networks

We study the transient dynamics of an A+B→0 process on a pair of randomly coupled networks, where reactants are initially separated. We find that, for sufficiently small fractions q of cross couplings, the concentration of A (or B) particles decays linearly in a first stage and crosses over to a second linear decrease at a mixing time tx. By numerical and analytical arguments, we show that for symmetric and homogeneous structures tx∝(〈k〉/q)log(〈k〉/q) where 〈k〉 is the mean degree of both networks. Being this behavior is in marked contrast with a purely diffusive process, where the mixing time would go simply like 〈k〉/q, we identify the logarithmic slowing down in tx to be the result of a spontaneous mechanism of repulsion between the reactants A and B due to the interactions taking place at the networks' interface. We show numerically how this spontaneous repulsion effect depends on the topology of the underlying networks.
Line-Based SLAM Using Non-Overlapping Cameras in an Urban Environment

SUMMARY We propose a method of line-based Simultaneous Localization and Mapping (SLAM) using non-overlapping multiple cameras for vehicles running in an urban environment. It uses corresponding line segments between images taken by di ﬀ erent frames and di ﬀ erent cameras. The contribution is a novel line segment matching algorithm by warping processing based on urban structures. This idea signiﬁcantly improves the accuracy of line segment matching when viewing direction are very di ﬀ erent, so that a number of correspondences between front-view and rear-view cameras can be found and the accuracy of SLAM can be improved. Ad-ditionally, to enhance the accuracy of SLAM we apply a geometrical constraint of urban area for initial estimation of 3D mapping of line segments and optimization by bundle adjustment. We can further improve the accuracy of SLAM by combining points and lines. The position error is stable within 1.5m for the entire image dataset evaluated in this paper. The estimation accuracy of our method is as high as that of ground truth captured by RTK-GPS. Our high accuracy SLAM algorithm can be apply for generating a road map represented by line segments. According to an evaluation of our generating map, true positive rate around the vehicle exceeding 70% is achieved. key words: SLAM, manhattan world, bundle adjustment
Fork and Join Queueing Networks with Heavy Tails: Scaling Dimension and Throughput Limit

Parallel and distributed computing systems are foundational to the success of cloud computing and big data analytics. Fork-Join Queueing Networks with Blocking (FJQN/Bs) are natural models for such systems. While engineering solutions have long been made to build and scale such systems, it is challenging to rigorously characterize the throughput performance of ever-growing systems, especially in the presence of heavy-tailed delays. In this paper, we utilize an infinite sequence of FJQN/Bs to study the throughput limit and focus on regularly varying service times with index α>1. We introduce two novel geometric concepts - scaling dimension and extended metric dimension - and show that an infinite sequence of FJQN/Bs is throughput scalable if the extended metric dimension <α-1 and only if the scaling dimension łe α-1. These results provide new insights on the scalability of a rich class of FJQN/Bs.
A linear CO chemistry parameterization in a chemistry-transport model: evaluation and application to data assimilation

This paper presents an evaluation of a new linear parameterization valid for the troposphere and the stratosphere, based on a first order approximation of the carbon monoxide (CO) continuity equation. This linear scheme (hereinafter noted LINCO) has been implemented in the 3-D Chemical Transport Model (CTM) MOCAGE (MOdele de Chimie Atmospherique Grande Echelle). First, a one and a half years of LINCO simulation has been compared to output obtained from a detailed chemical scheme output. The mean differences between both schemes are about ±25 ppbv (part per billion by volume) or 15% in the troposphere and ±10 ppbv or 100% in the stratosphere. Second, LINCO has been compared to diverse observations from satellite instruments covering the troposphere (Measurements Of Pollution In The Troposphere: MOPITT) and the stratosphere (Microwave Limb Sounder: MLS) and also from aircraft (Measurements of ozone and water vapour by Airbus in-service aircraft: MOZAIC programme) mostly flying in the upper troposphere and lower stratosphere (UTLS). In the troposphere, the LINCO seasonal variations as well as the vertical and horizontal distributions are quite close to MOPITT CO observations. However, a bias of ~−40 ppbv is observed at 700 Pa between LINCO and MOPITT. In the stratosphere, MLS and LINCO present similar large-scale patterns, except over the poles where the CO concentration is underestimated by the model. In the UTLS, LINCO presents small biases less than 2% compared to independent MOZAIC profiles. Third, we assimilated MOPITT CO using a variational 3D-FGAT (First Guess at Appropriate Time) method in conjunction with MOCAGE for a long run of one and a half years. The data assimilation greatly improves the vertical CO distribution in the troposphere from 700 to 350 hPa compared to independent MOZAIC profiles. At 146 hPa, the assimilated CO distribution is also improved compared to MLS observations by reducing the bias up to a factor of 2 in the tropics. This study confirms that the linear scheme is able to simulate reasonably well the CO distribution in the troposphere and in the lower stratosphere. Therefore, the low computing cost of the linear scheme opens new perspectives to make free runs and CO data assimilation runs at high resolution and over periods of several years.
Diagnosis of transportation modes on mobile phone using logistic regression classification

The aim of this study is to detect transportation modes of people by using smartphone sensors. Therefore, a mobile application was developed for this purpose and global positioning system (GPS), accelerometer, and gyroscope sensor data were collected while the subjects were walking, running, biking, and travelling by bus or by car. The application was running for over 8 h. Sensor data were tagged with 12 s intervals and 2500 patterns were obtained. Eleven features were selected from the data set and machine learning methods were applied to detect transportation modes using different sensor combinations. Performances of the methods were discussed in terms of accuracy ratios. Best results were obtained from GPS, accelerometer, and gyroscope sensor combination data using logistic regression method with 99.6% accuracy rate.
Latent Tuberculosis Treatment Compliance in Children: A 10-Year Experience.

W read with interest the recent article by Guix-Comellas et al regarding treatment adherence to antituberculosis drugs in children. The authors reported a completion rate of 74% (37/50) in children treated for latent tuberculosis infection (LTBI). Language barrier, being born abroad and development of toxicity were the main risk factors for nonadherence. Currently, the most frequently used regimens for treating LTBI are isoniazid monotherapy (INH m ) for 6 or 9 months, followed by the combination of isoniazid and rifampicin (INH/RIF) for 3 or 4 months. However, the long duration of INH m and the fact that it is a prophylactic treatment administered in asymptomatic patients lead to poor compliance, with completion rates ranging between 38% and 72%. Our hospital, the Meyer Children’s University Hospital, is a 198-bed tertiary care university hospital in Florence, Italy. In the infectious diseases unit, about 70 LTBI and 25 active TB cases are evaluated every year. We retrospectively reviewed records of children with LTBI between January 2007 and December 2016. Overall, 64 children treated with INH m and 377 treated with INH/RIF were evaluated during the study period (Table 1). Seven of 441 patients (1.6%) did not follow the prescribed regimen. Of those, in 6 cases, INH/RIF had been prescribed and all patients were children who had undergone TB screening as adopted from countries with high TB prevalence. Furthermore, 13 of 64 children (20.3%) receiving INH m and 23 of 377 (6.1%) receiving INH/RIF did not complete the full length of treatment. Median duration of therapy was 69 (interquartile range, 61–89) and 36 (interquartile range, 16–61) days in INH m and in INH/RIF treatment groups, respectively. The percentage of patients who completed the treatment was acceptable in both groups, while being significantly higher in children receiving INH/RIF compared with children receiving INH m (92.3% vs. 78.1%; P = 0.005, 95% confidence interval: 2.99–28.4). Considering age, sex, country of origin, reason for investigation, and side effects, no statistically significant differences in treatment compliance were found within the 2 groups (Table 1). Side effects did not influence treatment adherence in
Developing students’ mathematical and computational knowledge to investigate mooring line in ocean engineering

The rapid development of fast, powerful, and affordable computer technology has provided educators options to introduce innovations in teaching and learning process. The purpose of this study is to investigate the effect of computational simulations on students' understanding of marine mooring line tension in ocean engineering course. Instructional strategies need to incorporate mathematical and computational knowledge into their practice project so that students can use its core concepts to solve interdisciplinary problems. By writing students own Matlab program, students will demonstrate the effect of mathematical and computational tools on the analysis of ocean structural dynamics. The effectiveness of instructional methods by investigating learning gains, instructional effect, and student perceptions about the course are evaluated. Through the teaching practice, students significantly increase their understanding of ocean engineering concepts.
Molecular features in young vs elderly breast cancer patients and the impacts on survival disparities by age at diagnosis

Young and elderly breast cancer patients are more likely to have a poorer outcome than middle‐aged patients. The intrinsic molecular features for this disparity are unclear. We obtained data from the Cancer Genome Atlas (TCGA) on May 15, 2017 to test the potential mediation effects of the molecular features on the association between age and prognosis with a four‐step approach. The relative contributions of the molecular features (PAM50 subtype, risk stratification, DNAm age, and mutations in TP53, PIK3CA, MLL3, CDH1, GATA3, and MAP3K1) to age disparities in survival were estimated by Cox proportional hazard models with or without the features. Young patients were significantly more likely to have basal‐like subtype, GATA3 mutations, and younger DNA methylation (DNAm) age than middle‐aged patients (P < .05). Both the young and elderly patients had a significantly increased risk of breast cancer recurrence after adjusted by race, tumor size, and node status (Hazard ratio [HR] (95% confidence interval [CI]): 2.81 [1.44, 5.45], 2.37 [1.45, 3.89], respectively). This increased risk was weakened in the young patients after further adjustments in the molecular features, particularly basal‐like subtype, GATA3 mutations, and DNAm age (HR [95%CI]: 1.87 [0.81, 4.32]), resulting in 33.5% decreased risk of recurrence. Meanwhile, the adjustments of the molecular features did not alter the recurrence risk for the elderly patients. Compared with middle‐aged patients of breast cancer, poorer prognosis of elderly patients may be caused by aging, while poorer prognosis of young patients was probably mediated through intrinsic characteristics, such as basal‐like subtype, GATA3 mutations, and DNAm age of the cancerous tissues.
Immunological blocking of spermidine‐mediated host–pathogen communication provides effective control against Pseudomonas aeruginosa infection

Pseudomonas aeruginosa is known to cause life‐threatening infections. The previous studies showed that the type III secretion system (T3SS) of this pathogen is a key virulence determinant, which is activated by polyamines signals spermidine (Spd) and spermine (Spm) from mammalian host. To test the potential of blocking host–pathogen communication in disease control, in this study we developed a high potency mouse monoclonal antibody (Mab 4E4, IgG1 sub‐isotype) by using Spm–protein conjugate as an immunogen. Antibody specificity analysis showed that the antibody specifically recognize Spd and Spm. In vitro study showed the antibody significantly protected A549 cells against P. aeruginosa infection, and this protection was achieved by blocking polyamine uptake and downregulating T3SS expression. In vivo single injection of mouse with Mab 4E4 drastically reduced the serum polyamine level, which was maintained for more than 1 week. In a murine model of P. aeruginosa acute infection, injection of Mab 4E4 protected mice from lung injury and significantly improved the survival rate of mice.
Identification and ultra‐high‐performance liquid chromatography coupled with high‐resolution mass spectrometry characterization of biosurfactants, including a new surfactin, isolated from oil‐contaminated environments

Biosurfactant‐producing bacteria were isolated from samples collected in areas contaminated with crude oil. The isolates were screened for biosurfactant production using qualitative drop‐collapse test, oil‐spreading and emulsification assays, and measurement of their tensoactive properties. Five isolates tested positive for in the screening experiments and displayed decrease in the surface tension below 30 mN m−1. The biosurfactants produced by these isolates were further investigated and their molecular identification revealed that they are bacteria related to the Bacillus genus. Additionally, the biosurfactants produced were chemically characterized via UHPLC‐HRMS experiments, indicating the production of surfactin homologues, including a new class of these molecules.
Components, skills and training for conducting initial telephone consultations in primary care: a scoping review protocol

Review objective/question: The objective of this scoping review is to examine the characteristics of initial telephone consultations conducted in primary care settings and to map the existing evidence on the components, skills and training recommended for initial telephone consultations in current primary care. This scoping review will be guided by the following questions:What components are included or are recommended in the literature to be included in primary care initial telephone consultations? What skills are reported or recommended in the literature for primary care practitioners to deliver in initial telephone consultations? What training is recommended for primary care practitioners delivering initial telephone consultations?