Miracle-dz/UniFAR-FTUs huggingface dataset:
A latent class analysis of antisocial personality disorder symptom data from a multi-centre family study of alcoholism.

AIMS To determine if there are subtypes of Antisocial Personality Disorder (ASPD), as manifested by distinctive symptom profiles or by associations with alcohol, other drug dependence or other psychiatric disorders. METHODS Data on 38 symptoms of ASPD (including childhood conduct disorder) obtained from probands, their relatives and controls (2834 females and 3488 males) recruited for the Collaborative Study on the Genetics of Alcoholism (COGA) were analyzed using latent class analysis. Associations of the resulting latent classes with alcohol dependence (AD) and other psychiatric disorders were examined. FINDINGS Among women, a 4-class solution was obtained in which conduct disorder and ASPD were found almost exclusively in the most severely affected class with two additional classes with mild and moderate behavior problems also identified. A strong linear trend (p < 0.001) for AD was observed, with each successive class manifesting a higher prevalence than the previous class. Milestones of drinking careers and dependence on other drugs also showed a strong association with class severity. Among men, a 5-class solution was obtained and, like women, the highest prevalence of ASPD (74.6%) was found in the most severely affected class. Somewhat unexpected was the observation that prevalence of AD was equivalent in the two most severe classes. The data for men indicated a class with a milder spectrum of childhood misbehaviors but with an adult ASPD profile--as well as other psychiatric co-morbidity--that was comparable to the most severe class. CONCLUSIONS Overall, findings from both men and women did not support the existence of subtypes of ASPD, but rather indicated a disorder distributed on a severity spectrum.
Silymarin and dimercaptosuccinic acid ameliorate lead-induced nephrotoxicity and genotoxicity in rats

We studied the effect of silymarin and dimercaptosuccinic acid (DMSA), a chelating agent that was administered individually or in combination against lead (Pb) toxicity in rats. Wistar rats (200 ± 20) were randomly divided into five groups. Group A served as a control. Groups B–E were exposed to 2000 ppm of lead acetate in drinking water for 8 weeks. Group B served as a positive control. Group C received silymarin (100 mg kg−1 orally) for 8 weeks. Group D received DMSA (75 mg kg−1 orally) once daily for the last 5 days of treatment. Group E received DMSA and silymarin as groups C and D, respectively. The effect of Pb was evaluated and accordingly the treatments on blood lead levels (BLLs), renal system, and genotoxic effects were calculated using comet assay. The BLLs were significantly increased following the exposition of lead acetate. The administration of silymarin and DMSA provided reduction in BLLs. Silymarin and DMSA provided significant protection on the genotoxic effect of Pb. The toxic effect of Pb on kidneys was also studied. Our data suggest that silymarin and DMSA improve the renal histopathological lesions.
An Analysis of Join Processing in Sensor Networks

Wireless sensor networks have received much attention recently. Given their autonomy, flexibility and large range of functionality, they can be used as an effective and discrete means for monitoring data in many domains. Typically the network autonomy implies a limited and relatively small amount of energy for its operation. Hence, an important challenge they pose is how to process queries, i.e., manage and communicate data, in an energy-efficient manner within the network. In this paper we consider the problem of how to process join queries in a wireless sensor network. Unlike other types of queries, join queries have received little attention in the literature, despite their importance. We propose a few strategies for processing join queries, focusing on where (which sensor node(s)) to process data, and investigate their performance across several scenarios. Not surprisingly, our experiments show that no single strategy can be considered competitive for all scenarios. In order to avoid the potential high cost of using a fixed strategy for processing all queries, we develop a cost-based model that can be used to select the best join strategy for the query at hand. Our results confirm that, given a set of queries, selecting the join strategy based on the cost model is always better than using any fixed strategy for all queries.
Generalization of the area method for the determination of the parameters of a non-ideal solar cell

Reduction a une forme explicite, au moyen d'une rotation des coordonnees de l'equation de la courbe courant-tension d'une cellule solaire de resistances seriee en parallele finies. Etablissement d'une expression analytique de l'aire stiuee en dessous de la courbe. Utilisation de l'aire evaluee numeriquement a partir d'une courbe experimentale pour determiner les differents parametres de la cellule
Design of Ultrawideband High-Efficiency Extended Continuous Class-F Power Amplifier

Total bandwidth of existing wireless communication technologies covers a wide frequency range of over one octave. But most existing power amplifier configurations cannot meet this requirement while at the same time maintaining a high efficiency. Therefore, a new structure that can achieve multioctave bandwidth is proposed in this paper together with the design methodology. The difficulty in realizing a bandwidth larger than one octave lies in the overlapping of fundamental and harmonic frequencies. Regarding this problem, the continuous class-F mode is extended to allow a resistive second harmonic impedance, rather than the pure reactive one. With the relaxed design requirements and overlapping design space of fundamental and second harmonic frequencies, harmonic tuning and fundamental frequency matching networks can be designed separately. More importantly, broadband matching for fundamental frequencies can be implemented simply by considering only three fundamental frequency points using the multiple frequencies matching method. To verify the validity of the proposed methodology, a multioctave power amplifier was designed, fabricated, and measured. Measured results verify a wide bandwidth of 128.5% from 0.5 to 2.3 GHz. Over this frequency range, drain efficiency was larger than 60% with output power greater than 39.2 dBm and large signal gain larger than 11.7 dB.
Retinal Hypercholesterolemia Triggers Cholesterol Accumulation and Esterification in Photoreceptor Cells*

The process of vision is impossible without the photoreceptor cells, which have a unique structure and specific maintenance of cholesterol. Herein we report on the previously unrecognized cholesterol-related pathway in the retina discovered during follow-up characterizations of Cyp27a1−/−Cyp46a1−/− mice. These animals have retinal hypercholesterolemia and convert excess retinal cholesterol into cholesterol esters, normally present in the retina in very small amounts. We established that in the Cyp27a1−/−Cyp46a1−/− retina, cholesterol esters are generated by and accumulate in the photoreceptor outer segments (OS), which is the retinal layer with the lowest cholesterol content. Mouse OS were also found to express the cholesterol-esterifying enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT1), but not lecithin-cholesterol acyltransferase (LCAT), and to differ from humans in retinal expression of ACAT1. Nevertheless, cholesterol esters were discovered to be abundant in human OS. We suggest a mechanism for cholesterol ester accumulation in the OS and that activity impairment of ACAT1 in humans may underlie the development of subretinal drusenoid deposits, a hallmark of age-related macular degeneration, which is a common blinding disease. We generated Cyp27a1−/−Cyp46a1−/−Acat1−/− mice, characterized their retina by different imaging modalities, and confirmed that unesterified cholesterol does accumulate in their OS and that there is photoreceptor apoptosis and OS degeneration in this line. Our results provide insights into the retinal response to local hypercholesterolemia and the retinal significance of cholesterol esterification, which could be cell-specific and both beneficial and detrimental for retinal structure and function.
Unbroken mirror neurons in autism spectrum disorders.

BACKGROUND The 'broken mirror' theory of autism, which proposes that a dysfunction of the human mirror neuron system (MNS) is responsible for the core social and cognitive deficits in individuals with autism spectrum disorders (ASD), has received considerable attention despite weak empirical evidence. METHODS In this electroencephalographic study, we examined mu suppression, as an indicator of sensorimotor resonance, concurrent with oculomotor performance while individuals (n = 20) with ASD and control participants (n = 20) either executed hand actions or observed hand actions or a moving dot. No difference in visual attention between groups was found as indicated by fixation duration and normalized fixation number on the presented stimuli. RESULTS The mu suppression over the sensorimotor cortex was significantly affected by experimental conditions, but not by group membership, nor by the interaction between groups and conditions. Individuals with ASD, similar to the controls, exhibited stronger mu suppression when watching hand actions relative to a moving dot. Notably, participants with ASD failed to imitate the observed actions while their mu suppression indicating the MNS activity was intact. In addition, the mu suppression during the observation of hand actions was positively associated with the communication competence of individuals with ASD. CONCLUSION Our study clearly challenges the broken mirror theory of autism. The functioning of the mirror neuron system might be preserved in individuals with ASD to a certain degree. Less mu suppression to action observation coupled with more communicational severity can reflect the symptom heterogeneity of ASD. Additional research needs to be done, and more caution should be used when reaching out to the media.
Human Interaction with Small Haptic Effects

This research investigates the ability of subjects to detect small haptic effects and the associated gains in task performance with various configurations of haptic stimuli. Variations in force amplitude, shape, and pulse duration used to create the effects are studied. An adaptive-threshold method is used to obtain subjects' detection thresholds for actively explored haptic icons ranging in size from 3 to 5 mm. Detection thresholds are compared for smooth versus rough actively-explored icons. Subjects' detection thresholds for static icons (force pulses of 50 to 150 ms duration) are also measured. Results indicate that rough (sawtooth) haptic icons are more easily detected by a human subject than smooth (sinusoidal) icons of the same size. Transient vibrotactile cues may contribute to these observations. Mean subject performance, as measured by Fitts' information-processing rate and by clicks per minute, is shown to improve with the amplitude of haptic stimulus.
Muscular mass assessed by ultrasonography after administration of low-dose corticosteroids and muscle relaxants in critically ill hemiplegic patients.

BACKGROUND AIMS The present study investigates the influence of low-dose and short- term administration of corticosteroids and muscle relaxants on the muscular mass (MM) in hemiplegic ICU patients, with the aid of ultrasonography (U/S). METHODS Thirty-seven patients hospitalised in the ICU for 18.6+/-3.6 days, were included in the study. Sixteen patients did not receive either drug (group A), five patients received dexamethasone (24 mg/day) for 4 days (group B), eight patients received dexamethasone (24 mg/day) for 4 days and atracurium (0.3-0.6 mg/kg/h) for 2.8+/-0.4 days (group C), whereas eight other non-hemiplegic ICU patients comprised the control group. MM was measured in cm by U/S and serum Albumin (ALB, g/l) at the first and the tenth ICU hospitalisation day. The corresponding differences (DeltaMM, DeltaALB) were compared between the four groups of patients. RESULTS MM and ALB decreased significantly in all groups. DeltaMM was significantly higher in group C in comparison to all other groups, while DeltaMM was also higher in group B, when compared to the control and A groups. DeltaALB did not show significant inter-group differences. DeltaMM was significantly related to patients' age (r=0.41,P =0.001). CONCLUSIONS Muscular atrophy of the ICU hemiplegic patients is significantly influenced by the synchronous treatment with muscle relaxants and corticosteroids at low doses and for short term. This myopathy should be taken into account for the better prognosis and the safer outcome of the patient and U/S is suitable for accurate and non-invasive monitoring of MM.
Impaired procedural learning in language impairment: Results from probabilistic categorization

The Weather Prediction (WP) Task is a classical task of probabilistic category learning generally used for examining the dissociation of procedural and declarative memory. The current study focuses on performance of children with language impairment (LI) and compares their performance to that of typically developing (TD) children and adults with the aim of testing the procedural deficit hypothesis of LI (PDH; Ullman & Pierpont, 2005), which states that language impairment is not a specific linguistic phenomenon, but results from the dysfunction of a more general cognitive system: the procedural system. To test the generality of the procedural impairment, we needed a task that is dissimilar from language in that it does not build on sequential information. Children with language impairment show deficient learning on the Weather Prediction Task, which already appears at the early stages of the task. These results, in line with the PDH, point to the deficit of the procedural system in language impairment going beyond the language system. Whether this deficit is selective to the procedural system or is complemented by deficits in the declarative system is the subject of future studies.
Violence Against Widows in Nepal

Widows are a vulnerable population in Nepal. This study examined Nepalese widows’ experiences of violence, their coping strategies, and barriers faced in seeking help. Study participants were recruited from Women for Human Rights, an NGO in Nepal. A stratified purposive sampling approach was used to select 51 widows and 5 staff members for in-depth interviews. Twenty-seven women who experienced violence were included in this analysis. Data were analyzed and synthesized using a thematic analysis procedure. Widows reported a range of violent experiences perpetrated by family and community members that spanned psychological, physical, and sexual abuse. Women dealt with abusive experiences using both adaptive (e.g., attempting to move ahead, seeking social support, using verbal confrontation) and maladaptive coping strategies (e.g., suicidal thoughts or self-medication). However, they faced barriers to seeking help such as insensitivity of the police, perceived discrimination, and general lack of awareness of widows’ problems and needs. Findings highlight the need for interventions across the individual, family, community, and policy levels. Avenues for intervention include creating awareness about widows’ issues and addressing cultural beliefs affecting widows’ lives. Furthermore, efforts should focus on empowering widows, promoting healthy coping, and addressing their individual needs.
Heterologous Inducible Expression ofEnterococcus faecalis pCF10 Aggregation Substance Asc10 inLactococcus lactis and Streptococcus gordonii Contributes to Cell Hydrophobicity and Adhesion to Fibrin

ABSTRACT Aggregation substance proteins encoded by the sex pheromone plasmid family of Enterococcus faecalis have been shown previously to contribute to the formation of a stable mating complex between donor and recipient cells and have been implicated in the virulence of this increasingly important nosocomial pathogen. In an effort to characterize the protein further, prgB, the gene encoding the aggregation substance Asc10 on pCF10, was cloned in a vector containing the nisin-inducible nisA promoter and its two-component regulatory system. Expression of aggregation substance after nisin addition to cultures of E. faecalis and the heterologous bacteria Lactococcus lactis andStreptococcus gordonii was demonstrated. Electron microscopy revealed that Asc10 was presented on the cell surfaces ofE. faecalis and L. lactis but not on that ofS. gordonii. The protein was also found in the cell culture supernatants of all three species. Characterization of Asc10 on the cell surfaces of E. faecalis and L. lactisrevealed a significant increase in cell surface hydrophobicity upon expression of the protein. Heterologous expression of Asc10 on L. lactis also allowed the recognition of its binding ligand (EBS) on the enterococcal cell surface, as indicated by increased transfer of a conjugative transposon. We also found that adhesion of Asc10-expressing bacterial cells to fibrin was elevated, consistent with a role for the protein in the pathogenesis of enterococcal endocarditis. The data demonstrate that Asc10 expressed under the control of the nisA promoter in heterologous species will be an useful tool in the detailed characterization of this important enterococcal conjugation protein and virulence factor.
Cartilaginous choristoma of the tongue with an immunohistochemical study

By definition, choristomas are normal tissues found in anomalous topography. The cartilaginous features of these lesions are rare in the soft tissues of the oral cavity. The majority of cartilaginous choristomas of the tongue—the primary site of emergence of the oropharynx—are associated with adipose, fibrous or bone tissues—apart from that, only a few of these were confirmed by an immunohistochemical study. The neoplasm exclusively composed of chondromatous tissue is extremely rare in the tongue. This paper reports the clinical, surgical and pathological characteristics of a cartilaginous choristoma of the tongue diagnosed in a 64-year-old woman.
A piecewise generalized memory polynomial model for envelope tracking power amplifiers

This paper proposes a novel piecewise generalized memory polynomial model for envelope tracking power amplifiers (ETPAs). First, the input complex envelope signal is decomposed into several sub-signals by employing vector threshold decomposition technique and each sub-signal is processed separately by using generalized memory polynomial(GMP) model. Then, the selection of thresholds is discussed in detail to achieve optimum modeling accuracy. Simulation results show that the proposed model can provide about 3dB improvement of NMSE compared to the traditional memory polynomial(MP) model with same number of model coefficients, and can accurately describe the distinct characteristics of the ET system.
Phenotypic Effect of Isogenic uspA1 anduspA2 Mutations on Moraxella catarrhalis 035E

ABSTRACT The UspA surface antigen of Moraxella catarrhalis was recently shown to be comprised of two different proteins (UspA1 and UspA2) which share an internal region containing 140 amino acids with 93% identity (C. Aebi, I. Maciver, J. L. Latimer, L. D. Cope, M. K. Stevens, S. E. Thomas, G. H. McCracken, Jr., and E. J. Hansen, Infect. Immun. 65:4367–4377, 1997). Isogenic uspA1, uspA2, and uspA1 uspA2 mutants were tested in a number of in vitro systems to determine what effect these mutations, either individually or together, might exert on the phenotype of M. catarrhalis 035E. Monoclonal antibodies specific for UspA1 or UspA2 were used in an indirect antibody accessibility assay to prove that both of these proteins were expressed on the surface of M. catarrhalis. All three mutants grew in vitro at the same rate and did not exhibit autoagglutination or hemagglutination properties that were detectably different from those of the wild-type parent strain. When tested for the ability to adhere to human epithelial cells, the wild-type parent strain and the uspA2 mutant readily attached to Chang conjunctival cells. In contrast, theuspA1 mutant and the uspA1 uspA2 double mutant both attached to these epithelial cells at a level nearly 2 orders of magnitude lower than that obtained with the wild-type parent strain, a result which suggested that expression of UspA1 byM. catarrhalis is essential for attachment to these epithelial cells. Both the wild-type parent strain and theuspA1 mutant were resistant to the bactericidal activity of normal human serum, whereas the uspA2 mutant and theuspA1 uspA2 double mutant were readily killed by this serum. This latter result indicated that the presence of UspA2 is essential for expression of serum resistance by M. catarrhalis.
Uso eficiente y recuperación aparente de nitrógeno en maíz forrajero en suelos diferentes

La fertilizacion es el componente de mayor influencia en la produccion de maiz forrajero y el nitrogeno es el nutrimento de mayor demanda y el mas limitante para este cultivo. La correcta recomendacion de la dosis de fertilizacion mejora la eficiencia de los fertilizantes y reduce los riesgos de contaminacion de aguas superficiales y subterraneas. El objetivo del presente estudio fue evaluar la eficiencia de uso de nitrogeno en dos suelos de textura contrastante (arcilloso y arenoso). Los tratamientos evaluados fueron 0, 50, 175, 300 y 425 kg ha-1. Los mayores valores en el uso eficiente de nitrogeno y la recuperacion aparente del nitrogeno fueron mayores en el suelo de textura arcillosa. Con el incremento en las dosis de fertilizacion se aumento la produccion de biomasa pero dismiye el uso eficiente de nitrogeno asi como la recuperacion aparente del mismo aumentando asi el riesgo potencial de contaminacion ambiental.
Spectroscopic, calorimetric, and kinetic demonstration of conformational adaptation in peptide-antibody recognition.

Little is known about the extent to which protein flexibility contributes to antigen-antibody recognition and cross-reactivity. Using short coil peptides (leucine zippers) as model antigens, we demonstrate that a monoclonal antibody can force a noncognate peptide into a conformation that is similar to the conformation of the cognate peptide against which the monoclonal antibody is directed. Monoclonal antibodies 29AB and 13AD were raised against the 29-residue peptide LZ (Ac-EYEALEKKLAALEAKLQALEKKLEALEHG-amide) that forms a very stable coiled coil. The two antibodies cross-reacted strongly with the random coil analogue LZ(7P14P) that contains Lys-->Pro and Ala-->Pro substitutions in positions 7 and 14, respectively. The antibody-bound peptide LZ(7P14P) adopted an altered conformation that possibly was coiled coil-like, as shown by CD difference spectroscopy and fluorescence quenching experiments on coumarin-labeled peptides. Isothermal titration calorimetry revealed that the cross-reaction of antibodies 13AD and 29AB with the random coil peptide LZ(7P14P) exhibited a large unfavorable entropy. This, however, was strongly compensated by a more favorable enthalpy, resulting in only a small difference between the association constants for peptide LZ and LZ(7P14P), respectively. To investigate the opposite type of cross-reaction, monoclonal antibody 42PF was raised against the random coil peptide LZ(7P14P). 42PF cross-reacted with coiled coil peptide LZ by forcing it to dissociate into single chains. Enthalpy/entropy compensation again enabled the cross-reaction, which now was entropically favored and enthalpically disfavored. The rate of reaction of antibody 42PF with peptide LZ was controlled by the rate of dissociation of LZ into single chains. This observation, as well as the generally much slower reaction rate with the noncognate peptides, indicated that the cross-reactivity occurred because the antibody selected the conformer of the antigen that binds the strongest, a mechanism we call "induced fit by conformational selection. "