Miracle-dz/UniFAR-FTUs huggingface dataset:
Tetra-μ-acetato-κ4 O:O′;κ3 O,O′:O′;κ3 O:O,O′-bis[(acetato-κ2 O,O′)(1,10-phenanthroline-κ2 N,N′)europium(III)]

In the title centrosymmetric dinuclear EuIII complex, [Eu2(CH3COO)6(C12H8N2)2], each EuIII cation is coordinated by seven O atoms from five acetate anions and two N atoms from one phenanthroline ligand in a distorted tricapped trigonal-prismatic geometry. Four acetate anions bridge two EuIII cations to form the dinuclear complex, with an Eu⋯Eu distance of 3.9409 (8) Å. Weak intermolecular C—H⋯O hydrogen bonding is present in the crystal structure.
catena-Poly[[dichloridozinc(II)]-μ-1,1′-(butane-1,4-diyl)diimidazole-κ2 N 3:N 3′]

The title compound, [ZnCl2(C10H14N4)]n, is a coordination polymer consisting of zigzag chains propagating in [001], in which the metal cation exhibits a distorted tetrahedral ZnCl2N2 coordination. Adjacent chains are linked by intermolecular C—H⋯Cl hydrogen bonds, forming a three-dimensional supramolecular network.
Positron Emission Tomography

Most pathological conditions that arise within the human body are the result of underlying biochemical defects, and often the success or failure of subseq-uent treatment depends upon an early identification of these defects. For this reason, medical diagnostic techniques that reflect biochemical or metabolic behaviour have a special significance. One such technique, positron emission to-mography (PET), is based on the radiolabeling of substrates that are involved in the fundamental biochemical processes of the body. External detection and imaging of the radiation emitted by the radiolabel enables the chosen substrate to be monitored as it progresses along a particular metabolic pathway. In as far as the image of the emitted radiation reflects the biochemistry of the substrate in the body, abnormalities of biochemistry may be identified from the image. Thus, apart from the introduction into the body of a small quantity of radioac-tivity, PET is entirely non-invasive and without undue risk to the patient. To be successful, such an approach will require: the development of suitable instrumentation for imaging the radiation, the development of radiolabels with a well-understood fate within the body, the development of mathematical models that will explain in simple terms the kinetic behaviour of the tracers so as to distinguish pathology from normal function.
(2,2′-Bipyridine-κ2 N,N′)hydroxido[N-(4-tolylsulfonyl)alaninato-κ2 N,O 1]copper(II) hemihydrate

In the title complex, [Cu(C(10)H(12)NO(4)S)(OH)(C(10)H(8)N(2))]·0.5H(2)O, the Cu(II) ion shows a distorted square-pyramidal coordination geometry with two N atoms from the 2,2'-bipyridine ligand and one N and one O atom from the N-tosyl-α-alaninato ligand forming the basis of the coordination polyhedron and another O atom of the hydroxo group acting as the apex of the pyramid. The solvent water mol-ecule is statistically disordered over two positions.
How (not) to inform patients about drug use: use and effects of negations in Dutch patient information leaflets

Under EU regulations, patient information leaflets (PILs) are required to be clear and understandable. Negations (e.g., not, no) are a linguistic aspect that may impact PIL comprehension, yet go unmentioned in these regulations. We conducted two studies to determine (1) how negations are used in Dutch PILs (study 1) and (2) the effects of negations on readers (study 2).
Effectiveness of a smoking cessation intervention in Dutch pharmacies and general practices

Purpose – The purpose of this paper is to test the effectiveness of a computer‐tailored smoking cessation intervention, distributed through 75 Dutch general practices (GP) and 65 pharmacies (PH) in a randomised control trial.Design/methodology/approach – Respondents receive a tailored letter or a thank you letter (control condition). Main outcome measures are a quit attempt, seven‐day abstinence and continued abstinence at follow‐up (PH: three and 12 months, GP: six months). Effect of use and appreciation of the tailored letter are also tested.Findings – In total, 1,019 smokers are recruited (545 in PH study, 474 in GP study). At 12‐month follow‐up (PH), respondents receiving the tailored letter report quit attempts significantly more often. No main effects are found in the GP sample. However, reading the tailored letter more than once (GP) and talking with others about the tailored letter (PH) are borderline significant predictors of quitting and point prevalence abstinence.Research limitations/implicati.
Bis(2,6-dihydroxybenzoato-κ2 O 1 ,O 1′)(nitrato-κ2 O,O′)bis(1,10-phenanthroline-κ2 N,N′)gadolinium(III)

In the mononuclear title complex, [Gd(C7H5O3)2(NO3)(C12H8N2)2], the Gd atom is in a pseudo-bicapped square-antiprismatic geometry formed by four N atoms from two chelating 1,10-phenanthroline (phen) ligands and by six O atoms, four from two 2,6-dihydroxybenzoate (DHB) ligands and the other two from a nitrate anion. π–π stacking interactions between phen–DHB [centroid–centroid distances = 3.5334 (18) and 3.8414 (16) Å] and phen–phen [face-to-face separation = 3.4307 (17) Å] ligands of adjacent complex molecules stabilize the crystal structure. Intramolecular O—H⋯O hydrogen bonds are observed in the DHB ligands.
Simple and Rapid Determination of Zafirlukast in Plasma by Ultra-performance Liquid Chromatography Tandem Mass Spectrometric Method: Application into Pharmacokinetic Study in Rabbits

Abstract Zafirlukast is a selective leukotriene receptor antagonist used for the prophylaxis and chronic treatment of asthma. The aim of the present study was to develop a simple sensitive ultra-performance liquid chromatography tandem mass spectroscopy method for rapid determination of zafirlukast in plasma. After a simple one step protein precipitation by acetonitrile, zafirlukast and montelukast (IS) were separated on Acquity UPLC BEHTM C18 column (50×2.1 mm, i.d. 1.7 µm, Waters, USA) using a mobile phase of acetonitrile:water containing 10 mM acetic acid (80:20, v/v) at a flow rate of 0.3 mL/min. Zafirlukast and IS were eluted at 0.51 and 1.1 min, respectively with a total run time of only 1.5 min. The mass spectrometric determination was carried out using an electrospray interface operated in the negative mode with multiple reactions monitoring mode. The precursor to product ion transitions of m/z 574.11>462.07 and m/z 584.2>472.1 were used to quantify zafirlukast and IS, respectively. The method was linear in the concentration range of 0.17–600 ng/mL with coefficients of determination greater than 0.996 and lower limit of quantitation of 0.17 ng/mL. Intra-day and inter-day accuracies were 88.3–113.9% and the precisions were ≤12.6%. Zafirlukast was found to stable under various storage and sample processing conditions as per guidelines of bio-analytical method validation. The method developed herein is simple and rapid, and was successfully applied for the pharmacokinetic study in rabbits.
Bis{[μ-bis(diphenylphosphanyl)methane-1:2κ2 P:P′]nonacarbonyl-1κ3 C,2κ3 C,3κ3 C-[(4-methylsulfanylphenyl)diphenylphosphane-3κP]-triangulo-triruthenium(0)} dichloromethane monosolvate

The asymmetric unit of the title triangulo-triruthenium compound, 2[Ru3(C25H22P2)(C19H17PS)(CO)9]·CH2Cl2, contains one triangulo-triruthenium complex molecule and one half-molecule of the dichloromethane solvent. The dichloromethane solvent molecule lies across a crystallographic inversion center leading to the molecule being disordered over two positions of equal occupancy. The bis(diphenylphosphanyl)methane ligand bridges an Ru—Ru bond and the monodentate phosphane ligand bonds to the third Ru atom. All phosphane ligands are equatorial with respect to the Ru3 triangle. In addition, each Ru atom carries one equatorial and two axial terminal carbonyl ligands. The three phosphane-substituted benzene rings make dihedral angles of 87.18 (11), 59.59 (10) and 89.28 (11)° with each other. The dihedral angles between the two benzene rings are 78.48 (11) and 87.58 (11)° for the two diphenylphosphanyl groups. In the crystal, the molecules are stacked along the a axis. Weak intermolecular C—H⋯π interactions stabilize the crystal structure.
Evaluating different physician's prescribing preference based instrumental variables in two primary care databases: a study of inhaled long‐acting beta2‐agonist use and the risk of myocardial infarction

Instrumental variable (IV) analysis with physician's prescribing preference (PPP) as IV is increasingly used in pharmacoepidemiology. However, it is unclear whether this IV performs consistently across databases. We aimed to evaluate the validity of different PPPs in a study of inhaled long‐acting beta2‐agonist (LABA) use and myocardial infarction (MI).
Di-μ-benzoato-κ3 O,O′:O′;κ3 O:O,O′-bis[(benzoato-κ2 O,O′)(1,10-phenanthroline-κ2 N,N′)cadmium]

The dinuclear title compound, [Cd2(C7H5O2)4(C12H8N2)2], lies on a crystallographic twofold axis. The CdII ions are connected by two bridging benzoate anions and each ion is seven-coordinated by five O atoms from three benzoate ligands and by two N atoms from 1,10-phenanthroline. The benzoate ligands adopt two different coordination modes, acting as bidentate and bridging tridentate ligands. The discrete neutral molecules further extend their structure into a three-dimensional supramolecular framework by intermolecular π–π [interplanar distances of 3.392 (4) Å] and C—H⋯π stacking interactions [H–mean plane = 2.567 (4) and 2.781 (4) Å].
Bis(bicyclo[2.2.1]hept-5-ene-2-carboxylato)-1κ2 O,O′;4κ2 O,O′-di-μ2-chlorido-1:2κ2 Cl;3:4κ2 Cl-octamethyl-1κ2 C,2κ2 C,3κ2 C,4κ2 C-di-μ3-oxido-1:2:3κ3 O;2:3:4κ3 O-tetratin(IV)

In the title compound, [Sn4(CH3)8(C8H9O2)2Cl2O2], the tetranuclear complex molecule has crystallographically imposed inversion symmetry. The coordination polyhedron about the two central Sn atoms is distorted trigonal–bipyramidal, whilst the two peripheral metal atoms bonded to the carboxylate groups have a distorted octahedral coordination geometry. In the crystal, molecules are connected by long Sn⋯O contacts [3.139 (11) Å], forming chains along [011].
Bis(μ-4-amino-3,5-dimethyl-4H-1,2,4-triazole-κ 2 N 1:N 2)bis(dibromidozinc)

The centrosymmetric dimeric title complex, [Zn2Br4(C4H8N4)2], is isotypic with its [Zn2Cl4(C4H8N4)2], [Zn2I4(C4H8N4)2] and [Co2Cl4(C4H8N4)2] analogues. The zinc atom is bonded to two N atoms belonging to triazole bridging rings and to two terminal bromide ligands, in a geometry close to tetrahedral. Weak N—H⋯Br hydrogen bonds, with the amine functions as donor groups, are observed in the crystal structure, forming a three-dimensional supramolecular network.
New and Controversial Aspects of Retinal Detachment.

This book was published as the result of an assembly at The Texas Medical Center in Houston, June 3 through 5, 1965. An international symposium on the new and controversial aspects of retinal detachment was conducted with nearly 50 authorities from various parts of the world contributing to the understanding of this disease. Although the monograph is not exhaustive, it none the less is broad in scope, containing chapters on morphology, pathology, etiology, classification, examination, treatment complications, and results. The first section of the book presents the latest concepts of the ultrastructure of the retina and the vitreous, details recent studies of autopsy eyes containing pathology that is known to be associated with retinal detachment, and investigates the genetic determination of vitreoretinal degeneration. The management of retinal detachment is considered at length. New diagnostic instrumentation and a classification of retinal detachment, based on prognosis, are described, and the judiciousness of
Calculating global risk: the key to intervention

The assessment of overall cardiovascular risk is a valuable and accepted means of identifying patients who are likely to benefit most from intervention to control individual cardiovascular risk. A straightforward and accurate means of calculating overall cardiovascular risk has been derived from the PROspective CArdiovascular Munster (PROCAM) Study, a large observational cohort study. The PROCAM risk calculator has several advantages over other risk calculators. For example, the algorithm derived from the Framingham study consistently and markedly overestimates the risk of myocardial infarction in the PROCAM population, or in a German cohort within the Multinational Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA) Study, administered by the World Health Organization. In addition, the PROCAM risk calculator incorporates a broader range of commonly measured diagnostic parameters than the Framingham risk calculator. The multivariate Cox proportional hazards model that supports the PROCAM risk calculator has also provided valuable information on the principal driving forces behind atherosclerotic cardiovascular disease, with age, the level of LDL-cholesterol, smoking, the level of HDL-cholesterol, systolic blood pressure, family history of myocardial infarction, diagnosis of diabetes, and triglycerides all making significant contributions. As in other studies, low HDL-cholesterol emerged as a significant and independent risk factor for coronary disease, providing support for strategies aimed at correcting low HDL-cholesterol in addition to those aimed at reducing elevated levels of LDL-cholesterol.
Randomized Clinical Trials in Counseling

As the field of counseling moves toward evidence-based practice, researchers and clinicians may be interested in conducting randomized clinical trials. Although the randomized clinical trial is not the only method for conducting effectiveness studies of counseling interventions, it is a design that can produce important results. This article discusses the foundational steps in designing a randomized clinical trial and provides suggestions for researchers who are interested in conducting this type of research.
Dexmedetomidine pharmacokinetic–pharmacodynamic modelling in healthy volunteers: 1. Influence of arousal on bispectral index and sedation

Background Dexmedetomidine, a selective α 2 -adrenoreceptor agonist, has unique characteristics, such as maintained respiratory drive and production of arousable sedation. We describe development of a pharmacokinetic-pharmacodynamic model of the sedative properties of dexmedetomidine, taking into account the effect of stimulation on its sedative properties. Methods In a two-period, randomized study in 18 healthy volunteers, dexmedetomidine was delivered in a step-up fashion by means of target-controlled infusion using the Dyck model. Volunteers were randomized to a session without background noise and a session with pre-recorded looped operating room background noise. Exploratory pharmacokinetic-pharmacodynamic modelling and covariate analysis were conducted in NONMEM using bispectral index (BIS) monitoring of processed EEG. Results We found that both stimulation at the time of Modified Observer's Assessment of Alertness/Sedation (MOAA/S) scale scoring and the presence or absence of ambient noise had an effect on the sedative properties of dexmedetomidine. The stimuli associated with MOAA/S scoring increased the BIS of sedated volunteers because of a transient 170% increase in the effect-site concentration necessary to reach half of the maximal effect. In contrast, volunteers deprived of ambient noise were more resistant to dexmedetomidine and required, on average, 32% higher effect-site concentrations for the same effect as subjects who were exposed to background operating room noise. Conclusions The new pharmacokinetic-pharmacodynamic models might be used for effect-site rather than plasma concentration target-controlled infusion for dexmedetomidine in clinical practice, thereby allowing tighter control over the desired level of sedation. Clinical trial registration NCT01879865.
catena-Poly[[(1,10-phenanthroline-κ2 N,N′)lead(II)]-di-μ-nitrato-κ3 O,O′:O′′;κ3 O:O′,O′′-[(1,10-phenanthroline-κ2 N,N′)lead(II)]-bis(μ-2,2,2-trichloroacetato-κ2 O:O′)]

In the title PbII complex, [Pb2(C2Cl3O2)2(NO3)2(C12H8N2)2]n, the 1,10-phenanthroline ligand is chelating, the nitrate anion chelates one PbII ion and simultaneously bridges a neighbouring PbII ion via the third O atom, and the trichloroacetate anion is bidentate, bridging two PbII ions. The coordination geometry is based on a pentagonal–bipramidal geometry defined by an N2O5 donor set with no obvious stereochemical role for the lead-bound lone pair of electrons. The coordination polymer has a zigzag topology along [010] and comprises alternating eight-membered {PbONO}2 and {PbOCO}2 rings.
Subtotal Septal Reconstruction: An Update

Abstract Subtotal septal reconstruction is a surgical technique used to reconstruct severe septal deviations that are not easily repaired using less invasive methods. Patients with identifiable septal fractures across the caudal or dorsal segments of the L-strut are good candidates. These patients may present with deformities such as the deviated nose or saddle nose. Adequate autologous cartilage is needed to reconstruct the septum. The deviated segments of the nasal septum are removed and then reconstructed by replacing the caudal septum with a straight piece of septal cartilage fixated to the nasal spine. The bilateral extended spreader grafts fixated to the remnant dorsal strut is then fixed to the caudal septal replacement graft to reconstitute the L-strut. In some cases, the dorsal strut may overlap the caudal portion of the L-strut to complete the repair. Care must be taken in setting nasal length, projection, rotation, and supratip break. If these parameters are not set very carefully deformity may ensue. Other potential complications include change in the upper lip smile or a crease forming in the upper lip when the patient smiles. This is a complex technique and must be performed with special care to avoid deformity.
Use of tilt-in-space in seating systems for adults with physical disabilities

Abstract Aims: Clinicians increasingly recommend tilt-in-space (TIS) within wheelchair and seating prescriptions to reportedly prevent pressure ulcers; however, it is often unclear what the optimum tilt angle should be. This review aims to determine the use and effectiveness of TIS in seating systems. Methodology: A search of eight electronic databases was completed, namely, Medline, CINAHL, BNI, EMBASE, ASSIA, PubMed, OTDBase, and ISI Web of Science Conference Proceedings; using the keywords TIS, seating, wheelchairs, pressure ulcer, and pressure sores. Databases were searched for articles written in English between 2000 and the end of August 2012. Articles included primary research; TIS as the intervention; and had adult participants. Results: After removal of duplicates and application of inclusion criteria, 12 studies were eligible for this review. Findings show that TIS was used to manage pressure and fatigue, prevent sliding, aid skin perfusion, and facilitate user comfort. Conclusions: Reasons for using TIS will influence the degree of tilt required for the chair occupant; nonetheless, it remains difficult to specify either the optimum degree of tilt or the duration for use in TIS seating systems. In order to build an evidence base, clinicians need to be very explicit on their reasons for prescribing TIS.
Adjunct fixation with a Kirschner wire or a plate for lateral unicondylar humeral fracture stabilization

OBJECTIVE To compare the biomechanical properties of using an interfragmentary 1.6 mm Kirschner wire or a 2.7 mm reconstruction plate as adjunctive epicondylar stabilization in simulated comminuted lateral unicondylar humeral fractures stabilized with a transcondylar 4.5 mm cortical screw. STUDY DESIGN Cadaveric biomechanical assessment. SAMPLE POPULATION Paired humeri harvested from 9 young, skeletally mature dogs. METHODS Simulated comminuted lateral unicondylar humeral fractures were stabilized with a transcondylar 4.5 mm cortical screw placed in lag fashion. Adjunct fixations consisting of a 1.6 mm Kirschner wire on one side, and a 2.7 mm reconstruction plate on the contralateral side, were tested within paired humeri. Repaired humeri were axially loaded to failure and construct stiffness, yield load, and load to failure were obtained from the load-deformation curves. RESULTS Stiffness (mean ± SD: 577 ± 245 vs 310 ± 71 N/mm; P = .01), yield load (mean ± SD: 2389 ± 572 vs 1017 N ± 292; P = .0002), and load at failure (mean ± SD: 3351 ± 358 vs 1693 ± 363 N; P = .009) were greater in constructs incorporating a reconstruction plate rather than a Kirschner wire. CONCLUSION Our results support the recommendation for adjunct fixation of comminuted lateral unicondylar humeral fractures with an epicondylar plate.
Motherhood: is it good for women's mental health?

There is ongoing debate regarding whether the child‐bearing years, including the postpartum period, are a time of increased risk for mental health problems in women. Comparisons of the mental health of mothers and childless women have inconsistent findings. This is probably attributable to differences in the kinds of mothers and non‐mothers investigated, and variations in the conceptualisation of mental health, but suggests that firm conclusions about the relationship between motherhood and women's mental health remain less clear than claimed. This study investigated the relationship between motherhood and mental health in a population‐based, cross‐sectional survey of a broadly representative sample of 569 women aged 30–34 years living in Victoria, one Australian state, in 2005. It was found that the rates of mental health conditions in mothers, including those who had given birth in the preceding year, were no higher than in women without children. Further, mothers reported significantly better subjective well‐being and greater life satisfaction than childless women. These data suggest that being a mother is associated with enhanced mental health for women, and challenge the view that the child‐bearing years are a period of diminished psychological well‐being for women.
An in vitro wound healing model for evaluation of dermal substitutes

Reepithelialization of skin wounds is essential to restore barrier function and prevent infection. This process requires coordination of keratinocyte proliferation, migration, and differentiation, which may be impeded by various extrinsic and host‐dependent factors. Deep, full‐thickness wounds, e.g., burns, are often grafted with dermal matrices before transplantation of split‐skin grafts. These dermal matrices need to be integrated in the host skin and serve as a substrate for neoepidermis formation. Systematic preclinical analysis of keratinocyte migration on established and experimental matrices has been hampered by the lack of suitable in vitro model systems. Here, we developed an in vitro full‐thickness wound healing model in tissue‐engineered human skin that allowed analysis of the reepithelialization process across different grafted dermal substitutes. We observed strong differences between porous and nonporous matrices, the latter being superior for reepithelialization. This finding was corroborated in rodent wound healing models. The model was optimized using lentivirus‐transduced keratinocytes expressing enhanced green fluorescent protein and by the addition of human blood, which accelerated keratinocyte migration underneath the clot. Our model shows great potential for preclinical evaluation of tissue‐engineered dermal substitutes in a medium‐throughput format, thereby obviating the use of large numbers of experimental animals.
Glycaemic index of a cereal-pulse mix (diabetic mix) in non insulin dependent diabetes mellitus (NIDDM) subjects

The glycaemic index (GI) and triglyceride response was determined in 20 non insulin dependent diabetes mellitus subjects who were given a 50 g carbohydrate portion of the test meal ‘khichadi’ (a steam cooked savoury preparation) made out of the cereal-pulse mix containing wheat grits, soyabean, guar seeds, fenugreek seeds, green gram whole, red gram dhal, lentil and black gram dhal. The mean GI value for the test meal is 42.72. Compared with the blood glucose response for a 50 g glucose load, the test meal elicited significantly lower responses at 1 h and 2 h intervals. The test meal also showed a lower triglyceride response.