Miracle-dz/UniFAR-FTUs huggingface dataset:
ESTIMATION MODEL FOR KANSEI ANALYSIS OF VISUAL FATIGUE

The general term of the malfunction condition which treating the information management system accompanied by VDT (Visual Display Terminals) is called technostress, and is one of the social problems . If a system is able to recommend an improvement of work environment and rest to a user , it will lead to reduction and prevention of fatigue of a user. However, the internal state of fatigue of a worker is an uncertainty domain , and the system needs to estimate the data in which it is difficult to observe directly using observed value. In this paper, we deal with fatigue of the worker during VDT work , and construct a model using Bayesian networks. In order to obtain a better reasoning result , it is necessary to deal with VDT work information and user information such as both psychological and physiological information , comprehensively.
Obesity and Heart Failure in a Health Area

Objective: To analyze the relationship of the Body Mass Index (BMI) with heart failure in a health area. Method: Observational descriptive study of the 161 patients who had been diagnosed in the Health Area between January 2014 and December 2016. Among other demographic, clinical and analytical data, the BMI was analyzed based on weight and height at the first visit to the unit, using the formula: weight (in kilograms)/square of height (in meters). Once obtained, the relationship between BMI and 2-year survival was evaluated. Four subgroups of patients were analyzed, based on their BMI, based on the criteria defined by the World Health Organization (WHO) in 1999 (Technical Report Series, No. 854, Geneva: 1999): low weight (BMI < 20.5), normal weight (BMI of 20.5 to < 25.5), overweight (BMI of 25.5 to < 30) and obesity (BMI ≥ 30). Statistical analysis was carried out using the statistical package SPSS® 24.0 for Windows. The association between BMI as a continuous variable and 2-year mortality. Results: Of the participants, 81 were obese (50.8%), being 33 men and 48 women. The average age of the obese is 80.32 +/- 9.23 years. The main causes of heart failure in 62.2% had diagnosed some type of heart disease, being: 29.2% Ischemic heart disease, 46.6% cardiac arrhythmias and 20.5% valvulopathies. BMI a significantly associated with mortality (p < age ischemic disease (0.001), gender hypertension diabetes and dyslipidemia (0.004). The relation of BMI with the use of Digoxin, As a Diuretics and Spironolactone treatments has also been seen with higher BMI plus utilization. BMI is also associated with the number of admissions, greater number of concomitant chronic diseases and mortality. The scores obtained in the MLWHFQ quality of life questionnaire at the initial visit; the patients with low weight were those who obtained the highest score, which corresponds to a worse quality of life. There were no significant differences between the scores obtained by patients of normal weight, overweight and obese, although these showed a tendency to obtain a higher score. Conclusions: BMI has been shown to be associated with mortality, ischemic disease, sex, hypertension, diabetes and dyslipidemia in patients with heart failure.
The Effects of Seat Belt Legislation on British Road Casualties: A Case Study in Structural Time Series Modelling

Monthly data on road casualties in Great Britain are analyzed in order to assess the effect on casualty rates of the seat belt law introduced on January 31, 1983. Such analysis is known technically as intervention analysis. The form of intervention analysis that is used in this paper is based upon structural time series modelling and differs in significant respects from standard intervention analysis based upon ARIMA modelling. The relative merits of the two approaches are compared. Structural modelling intervention techniques are used to estimate the changes in casualty rates for various categories of road users following the introduction of the seat belt law. We first note the high rate of compliance with the seat belt law. By February 1983, the wearing rate had jumped to 90 percent and the rate has remained at approximately 95 percent from March 1983 onwards. There can be no doubt of the success of the law as regards to compliance. In considering the casualty figures we distinguish between those directly affected by the law, namely car drivers and front seat passengers, and those not directly affected by the law, that is car rear seat passengers, pedestrians and cyclists. Taking first numbers killed and seriously injured (KSI), we found a reduction of 23 percent for car drivers and 30 percent for front seat passengers. Thus, for those directly affected by the law, there have been substantial reductions. For rear seat passengers KSI we found a rise of 3 percent, for pedestrians a fall of one-half percent, and for cyclists an increase of 5 percent -- all three of these of these values being statistically insignificant. We conclude that there is no significant evidence of a change in numbers of KSI of those not directly affected. For numbers killed, we found for those directly affected a reduction of 18 percent for car drivers and 25 percent for front seat passengers. However, for those indirectly affected by the law, our model gave an increase of 27 percent for rear seat passengers, 8 percent for pedestrians, and 13 percent for cyclists. The value for rear seat passengers is highly significant and the other two values are on the borderline of significance. We conclude that there was an increase in fatalities of those not directly affected. We are unable to provide a completely satisfactory explanation of the difference between the figures for KSI and killed for rear seat passengers, pedestrians and cyclists. The article contains 13 pages of comments by discussants and 3 pages of authors' response. Language: en
An Enactive Approach to Artificial Hand

— Neuroprosthetics aims at restoring two essential components of the hand: both active manipulation and sensory feedback. In the last decade, several studies investigated the frontiers of neural elicitation of tactile sensation as a potentially helpful way to control the prosthesis. This finding is significant for the understanding of how biomedical engineering is impacting on/reshaping the concepts the concepts of experience and sensation. This contribution proposes an enactivist approach to elaborate a new pathway of understanding the experience mediated by neuroprosthesis.
The RISEN Project – A Novel Concept for Real-time on-site Forensic Trace Qualification

Following a chemical or biological attack, the rate at which a forensic investigation proceeds is critical for capturing perpetrators and preventing future incidents. Crime Scene Investigation (CSI) is a process that aims at recording the scene as it is first encountered and recognizing and collecting all the physical evidence potentially relevant to the solution of the case. Conventional CSI processes involve sensitive and delicate steps related with the identification and transportation of traces that may subsequently be subjected to laboratory analysis, a process that can take several hours or days. In this paper, we present the Real-tIme on-site forenSic tracE qualificatioN (RISEN) project, an innovate concept in forensic investigations in the context of CSI of sites affected by a chemical or biological attack. Coordinated by ENEA, RISEN will develop a set of network-enabled real-time contactless sensors for handling traces on site and accurate 3D recreation mechanisms of the entire crime scene, providing an immersive environment for investigators to evaluate hypotheses and conduct highly detailed investigations. The RISEN concept will allow forensics investigators and judicial authorities, to gather high quality information from a vast list of visible and invisible traces (localisation, identification/classification, interpretation and labelling) from a crime scene through standardised reports and a secure way, also speeding-up the forensic investigation process. The RISEN project started in July 2020 and has a duration of 4 years. public assessed the
A Study of Identifying Structural Hole Spanners in Large Scale Networs

The expansion of internet and increasingly evolving Social Network Sites (SNS) has facilitated internet-users to access a common stage for communication. With the increase in communications between a group of internet-users or between a pair of individuals, keeping track of their interactions is becoming a complex task. Social Networks datasets contain valuable information that can be examined to extract useful patterns. Social Network Analysis (SNA) is a study of patterns and relations in data. This involves identifying Communities or sub-communities from a large network of nodes. The individuals or entities in such Networks are partitioned into closely connected groups called Communities. There can be network structures that connect two or more communities. The Individuals that connect communities in such networks are termed as Structural Hole Spanners (SHS). Closely related communities and Structural Hole Spanners play an important role in various business applications. Therefore the study of identifying the dense communities and highly qualified structural holes in a large network of nodes has become study of interest among researchers. The evolution of Big Data Analytics is making it feasible. This paper studies the techniques of community detection and structural holes identification in literature. It made a preliminary study on SHS and presented two popular Structural Holes Identification Methods with their results.
An Introduction to Semantic Rule Engine for Industrial Automation

- Industrial automation is the use of hardware and software with IoT. Temperature dependent workplaces are the heart of industrial civilization. Energy consumption can be reduces the costings and increases the productivity of an industry. By the complete industrial automation only we can control the whole energy sources with the support of internet of things. The use of IoT, the connection to input devices (for detection and sensing) and to output devices (for command and control) is required and it is done by the help of semantic rule engine.
Detecting Total Serum Testosterone by Chemiluminescence Immunoassays, Radioactive Assays, and Liquid-Chromatography Tandem Mass Spectrometry: A Comparative Study

Aim: LC-MS/MS is still considered the gold standard for detecting steroid hormones in clinic. The aim of this study was to compare the analytical sensitivity of chemiluminescence immunoassays (CLIA) platforms, radioimmunoassay (RIA) platform, and high-performance liquid-chromatography tandem mass spectrometry (LC-MS/MS) platform for detecting total testosterone (tTES) in human samples (males and females). Method: Sixty-nine healthy male serum samples and 114 female serum samples were collected. The serum testosterone was detected by automatic immunoassay systems of Beckman and SIEMENS, radioimmunoassay, and LC-MS/MS. Pearson’s correlation coefficients were calculated to assess the agreement of other platforms with LC-MS/MS. Result: When evaluating TES in males, the results detected by SIEMENS2000 had a good correlation with LC-MS/MS (r=0.986), followed by Beckman DXI800, while RIA showed a weak correlation. There was no statistical difference between the results detected by SIEMENS2000 compared to those detected by DXI800 (p=0.87). When evaluating TES in females, DXI800 showed a good correlation with LC-MS/ MS (r=0.8784). SIEMENS2000 had most of the detected values below its low limit, and the SIEMENS2000 results with definite values were not statistically different compared to DXI800 results. Conclusion: The results detection platforms (SIEMENS2000 and DXI800) both had a better correlation with those of LC-MS/MS than RIA. Yet, Siemens 2000 had better consistency with LC-MS/MS in detecting the serums with low tTES value than DXI800. the samples with definite values; were above the lowest limit of Simense (0.69nmom/L). The samples’ values the RIA obviously The correlation coefficient between the two immunoassay platforms and the LC-MS/MS was higher than that between RIA and LC-MS/MS in males. We further analyzed the samples’ results below 0.69nmol/L when using two chemiluminescence platforms.
Journal of the American Heart Association The Genesis of Pulmonary Edema

FEW problems in pathologic physiology have received more attention and caused more controversy than that of the genesis of lung edema. The reason for the interest is obvious in view of the frequency of occurrence and the potential gravity of the condition. The reason for the controversies over mechanism becomes quite apparent when one notes the diversity of the factors whose alteration may produce pulmonary edema. However, much of the earlier disagreement among students of the problem now seems to be resolving itself because of the recognition of the distinction between the primary or immediate, and the secondary or remote or indirect causes. Thus at one time much stress was placed upon "neurogenic" factors in pathogenesis, without adequate attention to the mechanisms by which the nervous factors themselves might operate. Likewise "toxic" factors were implicated, without precise location of their site and mode of action. Dr. Francis J. Haddy and the author are preparing a review of the literature on lung edema,* and the study of this literature has led to the views which are presented here. Lung edema in its incipient stages can be almost exclusively limited to interstitial swelling. It is not a major immediate disadvantage to the respiratory function, however, until alveolar fluid accumulation has occurred. The presence of free alveolar fluid and foam increases the diffusion distances for gas exchange and also greatly impedes alveolar ventilation.
FRACTIONATION AND QUANTITATIVE DIFFERENCES OF GLUTENIN FROM WHEAT VARIETIES VARYING IN BAKING QUALITy

Cereal Chemistry 53(2): 258-269 Properties of glutenin and other wheat proteins that may be responsible for varietal differences in wheat flour performance were investigated. The proteins from several wheat flours differing in mixing time and dough strengths were extracted with a solution of O.IN acetic acid, 3M urea, and O.OIN hexadecyltrimethylammonium bromide buffer. After dialysis and lyophilization, the extract was dissolved in 5.5M guanidine hydrochloride and passed through an agarose gel filtration column. The glutenin protein was separated into two fractions: I) a very high mol wt fraction eluting at the void volume, and II) some lower mol wt proteins eluting as a broad peak. ext, the gliadins and water-soluble proteins were eluted in close sequence. Glutenin I and II differed only slightly in amino acid analysis and gel electrophoresis patterns of _their subunits. However, the elution profiles (from the 4%agarose columns) of the extracts from the various wheats differed significantly, especially in the glutenin region. The ratio of glutenin I to glutenin II was generally higher in bread wheat flours exhibiting long mixing times and strong doughs. In accordance with observations by Orth and Bushuk, these flours also contained the highest amount of unextracted protein. Flours of weak dough wheats generally had lesser contents of both glutenin I and unextracted protein. A sufficient total amount of protein, and suitable proportions ofthe two glutenin fractions and the insoluble fraction, are necessary for a good baking flour.
Edinburgh Research Explorer Nedd8 processing enzymes in Schizosaccharomyces pombe

Background: Conjugation of the ubiquitin-like modifier Nedd8 to cullins is critical for the function of SCF-type ubiquitin ligases and thus facilitates ubiquitin conjugation and ultimately degradation of SCF substrates, including several cell cycle regulators. Like ubiquitin, Nedd8 is produced as a precursor that must first be processed before it becomes active. In Saccharomyces cerevisiae this is carried out exclusively by the enzyme Yuh1. Results: Here we show that in the fission yeast, Schizosaccharomyces pombe , the Yuh1 orthologue, Uch1, is not the sole Nedd8 processing enzyme. Instead it appears that deubiquitylating enzymes can efficiently process the Nedd8 precursor in vivo . Conclusions: Several enzymes contribute to Nedd8 precursor processing including a number of deubiquitylating enzymes. Δ Δ (45% of type). there is still processing activity unaccounted for by these 5 enzymes. activity be further reduced upon incubation with ubiquitin-aldehyde, o-phenanthroline. This suggests that other ubiquitin proteases could account for the remaining activity, but that these proteases are not metalloproteases.
ENHANCEMENT OF MILD HYPERTHERMIA- INDUCED APOPTOTIC CELL DEATH BY AUTOPHAGY ALTERATION IN MYELOGENOUS LEUKEMIA CELL LINE M-NFS-60

The present study investigates the effect of autophagy alteration on the cytotoxicity of mild hyperthermia (41 ºC, 1 h) toward M-NFS-60; a myelogenous leukemia cell line. Autophagy was inhibited by 5 mM NH 4 Cl which halts lysosomal enzymes and accordingly preventing autolysosomes formation. On the other hand, autophagy was enhanced by glucose starvation. Trypan blue exclusion method was used to measure M-NSF-60 cell viability after hyperthermia in the presence or absence of autophagy modulators. The induction of apoptosis and autophagy were detected morphologically by acridine Orange/Ethidium Bromide (AO/EB) staining assay and monodansylcadaverine (MDC) staining, respectively. Also the level of P62/SQSTM1 and cleaved caspases 3; autophagy marker and apoptosis marker, respectively were assessed by western blotting. The results of this work revealed that autophagy acts as a protective mechanism which reduces the cytotoxic effects of hyperthermia. Inhibition of autophagy by NH 4 Cl potentiated the tumor inhibitory effects of mild hyperthermia in M-NFS-60 cells. Autophagy induction by glucose starvation promoted the effectiveness of hyperthermia against M-NFS-60 cells more than autophagy inhibition by NH 4 Cl. These data suggesting the therapeutic efficiency of hyperthermia in leukemic patients could be improved by autophagy modulation. These results may represent a new strategy in leukemia treatment which is more effective and capable of reducing hyperthermia effective temperature and improving the quality life of patients.
Components of Attention in Grapheme-Color Synesthesia

Grapheme-color synesthesia is a condition where the perception of graphemes consistently and automatically evokes an experience of non-physical color. Many have studied how synesthesia affects the processing of achromatic graphemes, but less is known about the synesthetic processing of physically colored graphemes. Here, we investigated how the visual processing of colored letters is affected by the congruence or incongruence of synesthetic grapheme-color associations. We briefly presented graphemes (10 – 150 ms) to 9 grapheme-color synesthetes and to 9 control observers. Their task was to report as many letters (targets) as possible, while ignoring digit (distractors). Graphemes were either congruently or incongruently colored with the synesthetes ’ reported grapheme-color association. A mathematical model, based on Bundesen ’ s (1990) Theory of Visual Attention (TVA), was fitted to each observer ’ s data, allowing us to estimate discrete components of visual attention. The models suggested that the synesthetes processed congruent letters faster than incongruent ones, and that they were able to retain more congruent letters in visual short-term memory, while the control group ’ s model parameters were not signifi-cantly affected by congruence. The increase in processing speed, when synesthetes process congruent letters, suggests that synesthesia affects the processing of letters at a perceptual level. To
Analysis of Image Processing Techniques for Road Anomalies Detection

— his paper provides an overview and analysis of image processing concepts used for automated road anomalies detection. Several efforts have been made on past to develop a technology which may detect potholes automatically. Image processing is a vast area to be studied. Here we are reviewing the image processing techniques which are used for road network maintenance study. This paper presents the current practice of assessing road network using matlab.
Cloning and Functional Characterization of the Early-Lymphocyte-Speciﬁc Pb99 Gene

The Pb99 gene is speciﬁcally expressed in pre-B cells and thymocytes and not in mature B and T cells or nonlymphoid tissues, implying that it may function in early lymphoid development. We have previously described the cloning of an incomplete cDNA for Pb99 . Here we report the isolation of full-length cDNAs and genomic clones for the murine Pb99 gene and the mapping of its location to mouse chromosome 8. Sequence analyses of different Pb99 cDNA clones suggest that there may be at least three forms of the Pb99 protein generated by differential processing of the Pb99 transcript. The cDNA with the longest open reading frame encodes a putative protein that has seven hydrophobic domains similar to those of seven membrane-spanning proteins, such as the classical G protein-coupled receptors. To directly address the role of the Pb99 protein in lymphoid development, Pb99-deﬁcient mice were generated by isothiocyanate (FITC)-, or phycoerythrin (PE)-conjugated antibodies and were analyzed by a FACScan (Becton Dickinson). The following antibodies from Pharmingen were used in these studies: PE-conjugated anti-CD4 (RM4-5), FITC-conjugated anti-CD8 (53-6.7), Cyc- and FITC-conjugated anti-B220 (RA3-6B2), PE-conjugated anti-immunoglobulin M (IgM) (R6-60.2), FITC-conjugated anti-CD43 and PE-conjugated
MicroRNA expression profiles identify disease-specific alterations in systemic lupus 1 erythematosus and primary Sjögren's syndrome

The discovery of microRNAs (miRNAs) and their critical role in genetic control opened new 22 avenues in understanding of various biological processes including immune cell lineage commitment, differentiation, proliferation and apoptosis. However, a given miRNA may have hundreds of different mRNA targets and a target might be regulated by multiple miRNAs, thus the characterisation of dysregulated miRNA expression profiles could give a better 26 insight into the development of immunological disturbances in autoimmune diseases. The aim 27 of our study was to examine the changes in miRNA expression profiles in patients with 28 systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS). Eight SLE 29 patients, 8 pSS patients and 7 healthy subjects were enrolled in the investigation. MiRNAs 30 were isolated from peripheral blood mononuclear cells, and expression patterns were 31 determined with Illumina next-generation sequencing technology. Since the 32 immunopathogenesis of pSS and SLE encompasses pronounced B cell hyperactivity along 33 with specific autoantibody production, we paid a special attention on the association between 34 miRNA expression levels and altered peripheral B cell distribution. In SLE patients 135, while 35 in pSS patients miRNAs showed altered expression. Interestingly, the 25 miRNAs including miR-146a, miR-16 and miR-21, which were over-expressed in pSS patients, were 37 found to be elevated in SLE group, as well. On the contrary, we observed the down-regulation 38 of miR-150-5p, which is a novel and unique finding in pSS. Levels of several miRNAs over-expressed in SLE, were not changed in pSS, such as miR-148a-3p, miR-152, miR-155, miR-223, miR-224, miR-326 and miR-342. Expression levels of miR-223-5p, miR-150-5p, miR-155-5p and miR-342-3p, which miRNAs are potentially linked to B cell functions,