Miracle-dz/UniFAR-FTUs huggingface dataset:
Validity of a Microsensor-Based Algorithm for Detecting Scrum Events in Rugby Union.

PURPOSE Commercially available microtechnology devices containing accelerometers, gyroscopes, magnetometers, and global positioning technology have been widely used to quantify the demands of rugby union. This study investigated whether data derived from wearable microsensors can be used to develop an algorithm that automatically detects scrum events in rugby union training and match play. METHODS Data were collected from 30 elite rugby players wearing a Catapult OptimEye S5 (Catapult Sports, Melbourne, Australia) microtechnology device during a series of competitive matches (n = 46) and training sessions (n = 51). A total of 97 files were required to "train" an algorithm to automatically detect scrum events using random forest machine learning. A further 310 files from training (n = 167) and match-play (n = 143) sessions were used to validate the algorithm's performance. RESULTS Across all positions (front row, second row, and back row), the algorithm demonstrated good sensitivity (91%) and specificity (91%) for training and match-play events when the confidence level of the random forest was set to 50%. Generally, the algorithm had better accuracy for match-play events (93.6%) than for training events (87.6%). CONCLUSIONS The scrum algorithm was able to accurately detect scrum events for front-row, second-row, and back-row positions. However, for optimal results, practitioners are advised to use the recommended confidence level for each position to limit false positives. Scrum algorithm detection was better with scrums involving ≥5 players and is therefore unlikely to be suitable for scrums involving 3 players (eg, rugby sevens). Additional contact- and collision-detection algorithms are required to fully quantify rugby union demands.
Comparison of MRI‐derived vs. traditional estimations of fatty acid composition from MR spectroscopy signals

The composition of fatty acids in the body is gaining increasing interest, and can be followed up noninvasively by quantitative magnetic resonance spectroscopy (MRS). However, current MRS quantification methods have been shown to provide different quantitative results in terms of lipid signals, with possible varying outcomes for a given biological examination. Quantitative magnetic resonance imaging using multigradient echo sequence (MGE‐MRI) has recently been added to MRS approaches. In contrast, these methods fit the undersampled magnetic resonance temporal signal with a simplified model function (expressing the triglyceride [TG] spectrum with only three TG parameters), specific implementations and prior knowledge. In this study, an adaptation of an MGE‐MRI method to MRS lipid quantification is proposed.
Validation of electronic performance and tracking systems EPTS under field conditions

The purpose of this study was to assess the measurement accuracy of the most commonly used tracking technologies in professional team sports (i.e., semi-automatic multiple-camera video technology (VID), radar-based local positioning system (LPS), and global positioning system (GPS)). The position, speed, acceleration and distance measures of each technology were compared against simultaneously recorded measures of a reference system (VICON motion capture system) and quantified by means of the root mean square error RMSE. Fourteen male soccer players (age: 17.4±0.4 years, height: 178.6±4.2 cm, body mass: 70.2±6.2 kg) playing for the U19 Bundesliga team FC Augsburg participated in the study. The test battery comprised a sport-specific course, shuttle runs, and small sided games on an outdoor soccer field. The validity of fundamental spatiotemporal tracking data differed significantly between all tested technologies. In particular, LPS showed higher validity for measuring an athlete’s position (23±7 cm) than both VID (56±16 cm) and GPS (96±49 cm). Considering errors of instantaneous speed measures, GPS (0.28±0.07 m⋅s-1) and LPS (0.25±0.06 m⋅s-1) achieved significantly lower error values than VID (0.41±0.08 m⋅s-1). Equivalent accuracy differences were found for instant acceleration values (GPS: 0.67±0.21 m⋅s-2, LPS: 0.68±0.14 m⋅s-2, VID: 0.91±0.19 m⋅s-2). During small-sided games, lowest deviations from reference measures have been found in the total distance category, with errors ranging from 2.2% (GPS) to 2.7% (VID) and 4.0% (LPS). All technologies had in common that the magnitude of the error increased as the speed of the tracking object increased. Especially in performance indicators that might have a high impact on practical decisions, such as distance covered with high speed, we found >40% deviations from the reference system for each of the technologies. Overall, our results revealed significant between-system differences in the validity of tracking data, implying that any comparison of results using different tracking technologies should be done with caution.
Proteomic Delineation of the ArcA Regulon in Salmonella Typhimurium During Anaerobiosis*

Salmonella enterica serovar Typhimurium (S. Typhimurium) is one of the most used models for bacterial pathogenesis and successful infection requires its adaptation to the low oxygen environment in host gastrointestinal tracts. Central to this process is the Arc (aerobic respiratory control) two-component regulatory system that contains a sensor kinase ArcB and a response regulator ArcA. Nevertheless, a comprehensive profile of the ArcA regulon on the proteome level is still lacking in S. Typhimurium. Here we quantitatively profiled Salmonella proteome during anaerobiosis in an arcA-deleting mutant compared with its parental strain. In addition to known processes under its control, notably we found that ArcA represses ethanolamine utilization by directly binding to the promoter region of the eut operon. Furthermore, we found opposing changes of several bacterial genes on the protein and transcript levels in the arcA-deleting mutant including the virulence genes of Salmonella pathogenicity island 1 (SPI-1), thereby indicating potentially prevalent post-transcriptional regulatory mechanisms. Altogether, our study provides important new insights into ArcA-dependent bacterial physiology and virulence during Salmonella anaerobiosis.
Medical Question Similarity Calculation Based On Weighted Domain Dictionary

In the calculation of question similarity in the mobile medical question answering system, not all the importance of the words are the same. To solve the problem, we proposed a improved similarity calculation method based on the vector space model and combining the weighted domain dictionary for mobile health questions in question and answer system. Adding weight to field word in target question to bring a higher scores of similarity calculation, reduce the impact of non-field word in similarity calculation.
Comparison of the Anion Inhibition Profiles of the α-CA Isoforms (SpiCA1, SpiCA2 and SpiCA3) from the Scleractinian Coral Stylophora pistillata

Carbonic anhydrases (CAs, EC 4.2.1.1) are widespread metalloenzymes used by living organisms to accelerate the CO2 hydration/dehydration reaction at rates dramatically high compared to the uncatalyzed reaction. These enzymes have different isoforms and homologues and can be found in the form of cytoplasmic, secreted or membrane-bound proteins. CAs play a role in numerous physiological processes including biomineralization and symbiosis, as is the case in reef-building corals. Previously, molecular and biochemical data have been obtained at the molecular level in the branching coral Stylophora pistillata for two coral isoforms which differ significantly in their catalytic activity and susceptibility to inhibition with anions and sulfonamides. More recently it has been determined that the genome of S. pistillata encodes for 16 CAs. Here, we cloned, expressed, purified and characterized a novel α-CA, named SpiCA3, which is cytoplasmic and ubiquitously expressed in all the cell layers including the calcifying cells. SpiCA3 is the most effective CA among the coral isoforms investigated and the most efficient catalyst known up to date in Metazoa. We also investigated the inhibition profiles of SpiCA3 and compared it with those obtained for the two other isoforms in the presence of inorganic anions and other small molecules known to interfere with metalloenzymes. These results suggest that S. pistillata has adapted its CA isoforms to achieve the physiological functions in different physicochemical microenvironments.
Expanding Opportunities for Professional Development: Utilization of Twitter by Early Career Women in Academic Medicine and Science

The number of women entering medical school and careers in science is increasing; however, women remain the minority of those in senior faculty and leadership positions. Barriers contributing to the shortage of women in academics and academic leadership are numerous, including a shortage of role models and mentors. Thus, achieving equity in a timelier manner will require more than encouraging women to pursue these fields of study or waiting long enough for those in the pipelines to be promoted. Social media provides new ways to connect and augments traditional forms of communication. These alternative avenues may allow women in academic medicine to obtain the support they are otherwise lacking. In this perspective, we reflect on the role of Twitter as a supplemental method for navigating the networks of academic medicine. The discussion includes the use of Twitter to obtain (1) access to role models, (2) peer-to-peer interactions, and continuous education, and (3) connections with those entering the pipeline—students, trainees, and mentees. This perspective also offers suggestions for developing a Twitter network. By participating in the “Twittersphere,” women in academic medicine may enhance personal and academic relationships that will assist in closing the gender divide.
Lipid A Remodeling Is a Pathoadaptive Mechanism That Impacts Lipopolysaccharide Recognition and Intracellular Survival of Burkholderia pseudomallei

Burkholderia pseudomallei causes the severe disease melioidosis. The bacterium subverts the host immune system and replicates inside cells, and host mortality results primarily from sepsis-related complications. ABSTRACT Burkholderia pseudomallei causes the severe disease melioidosis. The bacterium subverts the host immune system and replicates inside cells, and host mortality results primarily from sepsis-related complications. Lipopolysaccharide (LPS) is a major virulence factor and mediator of sepsis that many pathogens capable of intracellular growth modify to reduce their immunological “footprint. ” The binding strength of B. pseudomallei LPS for human LPS binding protein (hLBP) was measured using surface plasmon resonance. The structures of lipid A isolated from B. pseudomallei under different temperatures were analyzed by matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS), and the gene expression of two lipid A remodeling genes, lpxO and pagL, was investigated. The LPS was characterized for its ability to trigger tumor necrosis factor alpha (TNF-α) release and to activate caspase-11-triggered pyroptosis by introduction of LPS into the cytosol. Lipid A from long-term chronic-infection isolates was isolated and characterized by MALDI-TOF MS and also by the ability to trigger caspase-11-mediated cell death. Lipid A from B. pseudomallei 1026b lpxO and pagL mutants were characterized by positive- and negative-mode MALDI-TOF MS to ultimately identify their role in lipid A structural modifications. Replication of lpxO and pagL mutants and their complements within macrophages showed that lipid A remodeling can effect growth in host cells and activation of caspase-11-mediated cytotoxicity.
Detecting Vehicle Illegal Parking Events using Sharing Bikes' Trajectories

Illegal vehicle parking is a common urban problem faced by major cities in the world, as it incurs traffic jams, which lead to air pollution and traffic accidents. Traditional approaches to detect illegal vehicle parking events rely highly on active human efforts, e.g., police patrols or surveillance cameras. However, these approaches are extremely ineffective to cover a large city. The massive and high quality sharing bike trajectories from Mobike offer us with a unique opportunity to design a ubiquitous illegal parking detection system, as most of the illegal parking events happen at curbsides and have significant impact on the bike users. Two main components are employed to mine the trajectories in our system: 1)~trajectory pre-processing, which filters outlier GPS points, performs map-matching and builds indexes for bike trajectories; and 2)~illegal parking detection, which models the normal trajectories, extracts features from the evaluation trajectories and utilizes a distribution test-based method to discover the illegal parking events. The system is deployed on the cloud internally used by Mobike. Finally, extensive experiments and many insightful case studies based on the massive trajectories in Beijing are presented.
Giok the Alien: An AR-Based Integrated System for the Empowerment of Problem-Solving, Pragmatic, and Social Skills in Pre-School Children

The use of technology for educational purposes is a consolidated reality, and many new tools are constantly being devised and offered for use with both normally developing children and children with special needs. Nonetheless, a detailed analysis of the processes being stimulated and of the goals being pursued is often lacking or absent. In this work we describe the design, development and preliminary testing of an integrated system which combines the use of smart devices, a physical cube, augmented reality (AR) technology, a smart TV, and a software application especially designed to stimulate cognitive and social functions in pre-school children. The system was tested with three groups of children (25 children in total) during kindergarten activities. The results show that the system is easy to understand, elicits high levels of participation and social interaction, favors strategic behaviors, and can be used by the children with limited need of instruction and support by the adult. The implications for empowerment in typically developing children and the possibilities for use with children who have specific impairments in social communication are discussed.
Towards Comparative Analysis of Open Fiscal Data

Open fiscal datasets have been published widely by different public administrations. These datasets include public budget and spending data. Unfortunately, the level of analysis that can be done is very limited, since there are not many contexts about the datasets that can be inferred from the published datasets. This contextual information may consist of essential information that can be used to understand the datasets better, such as statistical information regarding where the data comes from. In the semantic web domain, contextualizing these datasets can be made possible. This contextualization would enable analysis across different publicly published datasets, as well as answering a context-rich question (e.g., enlist the budget of all cities within the EU which has a certain number of population and area size). Unfortunately, there are several challenges that need to be solved before this vision can be attained.
Polyphenols Derived from Lychee Seed Suppress Aβ (1-42)-Induced Neuroinflammation

Amyloid-β (Aβ) is commonly recognized as the most important factor that results in neuronal cell death and accelerates the progression of Alzheimer’s disease (AD). Increasing evidence suggests that microglia activated by Aβ release an amount of neurotoxic inflammatory cytokines that contribute to neuron death and aggravate AD pathology. In our previous studies, we found that lychee seed fraction (LSF), an active fraction derived from the lychee seed, could significantly improve the cognitive function of AD rats and inhibit Aβ-induced neuroinflammation in vitro, and decrease neuronal injuries in vivo and in vitro. In the current study, we aimed to isolate and identify the specific components in LSF that were responsible for the anti-neuroinflammation effect using preparative high performance liquid chromatography (pre-HPLC), liquid chromatography-mass spectrometry (LC-MS), and nuclear magnetic resonance (NMR) methods. To this end, we confirmed two polyphenols including catechin and procyanidin A2 that could improve the morphological status of BV-2 cells and suppress the release, mRNA levels, and protein expression of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) through downregulating the nuclear factor-κB (NF-κB) signaling pathway using ELISA, RT-PCR, and Western blotting methods. Furthermore, catechin and procyanidin A2 could inhibit Aβ-induced apoptosis in BV-2 cells by upregulating Bcl-2 and downregulating Bax protein expression. Therefore, the current study illustrated the active substances in lychee seed, and first reported that catechin and procyanidin A2 could suppress neuroinflammation in Aβ-induced BV-2 cells, which provides detailed insights into the molecular mechanism of catechin and procyanidin A2 in the neuroprotective effect, and their further validations of anti-neuroinflammation in vivo is also essential in future research.
Identification and Growth Inhibitory Activity of the Chemical Constituents from Imperata Cylindrica Aerial Part Ethyl Acetate Extract

Imperata cylindrica (L.) Raeusch. (IMP) aerial part ethyl acetate extract has anti-proliferative, pro-apoptotic, and pro-oxidative effects towards colorectal cancer in vitro. The chemical constituents of IMP aerial part ethyl acetate extract were isolated using high-performance liquid chromatography (HPLC) and identified with tandem mass spectrometry (ESI-MS/MS) in combination with ultraviolet-visible spectrophotometry and 400 MHz NMR. The growth inhibitory effects of each identified component on BT-549 (breast) and HT-29 (colon) cancer cell lines were evaluated after 48/72 h treatment by MTT assay. Four isolated compounds were identified as trans-p-Coumaric acid (1); 2-Methoxyestrone (2); 11, 16-Dihydroxypregn-4-ene-3, 20-dione (3); and Tricin (4). Compounds (2), (3), and (4) exhibited considerable growth inhibitory activities against BT-549 and HT-29 cancer cell lines. Compounds (2), (3), and (4) are potential candidates for novel anti-cancer agents against breast and colorectal cancers.
Quality Assurance and Quality Control in the Global Trachoma Mapping Project

Abstract. In collaboration with the health ministries that we serve and other partners, we set out to complete the multiple-country Global Trachoma Mapping Project. To maximize the accuracy and reliability of its outputs, we needed in-built, practical mechanisms for quality assurance and quality control. This article describes how those mechanisms were created and deployed. Using expert opinion, computer simulation, working groups, field trials, progressively accumulated in-project experience, and external evaluations, we developed 1) criteria for where and where not to undertake population-based prevalence surveys for trachoma; 2) three iterations of a standardized training and certification system for field teams; 3) a customized Android phone–based data collection app; 4) comprehensive support systems; and 5) a secure end-to-end pipeline for data upload, storage, cleaning by objective data managers, analysis, health ministry review and approval, and online display. We are now supporting peer-reviewed publication. Our experience shows that it is possible to quality control and quality assure prevalence surveys in such a way as to maximize comparability of prevalence estimates between countries and permit high-speed, high-fidelity data processing and storage, while protecting the interests of health ministries.
Scalable Query N-Gram Embedding for Improving Matching and Relevance in Sponsored Search

Sponsored search has been the major source of revenue for commercial web search engines. It is crucial for a sponsored search engine to retrieve ads that are relevant to user queries to attract clicks as advertisers only pay when their ads get clicked. Retrieving relevant ads for a query typically involves in first matching related ads to the query and then filtering out irrelevant ones. Both require understanding the semantic relationship between a query and an ad. In this work, we propose a novel embedding of queries and ads in sponsored search. The query embeddings are generated from constituent word n-gram embeddings that are trained to optimize an event level word2vec objective over a large volume of search data. We show through a query rewriting task that the proposed query n-gram embedding model outperforms the state-of-the-art word embedding models for capturing query semantics. This allows us to apply the proposed query n-gram embedding model to improve query-ad matching and relevance in sponsored search. First, we use the similarity between a query and an ad derived from the query n-gram embeddings as an additional feature in the query-ad relevance model used in Yahoo Search. We show through online A/B test that using the new relevance model to filter irrelevant ads offline leads to 0.47% CTR and 0.32% revenue increase. Second, we propose a novel online query to ads matching system, built on an open-source big-data serving engine [30], using the learned query n-gram embeddings. Online A/B test shows that the new matching technique increases the search revenue by 2.32% as it significantly increases the ad coverage for tail queries.
Monitoring Athletes during Training Camps: Observations and Translatable Strategies from Elite Road Cyclists and Swimmers

Monitoring is an essential yet unstandardized component of managing athletic preparation. The purpose of this paper is to provide insight into the typical measurements and responses observed from monitoring elite road cyclist and swimmers during training camps, and translate these observations to practical strategies for other practitioners to employ. Twenty-nine male professional cyclists, 12 male and 19 female international swimmers participated in up to three of the eight 4–19 day training camps, held early in the season or leading into major competitions, at sea-level or moderate altitude. Monitoring included body mass and composition, subjective sleep, urinary specific gravity (USG), resting heart rate (HR) and peripheral oxygen saturation (SpO2) at altitude. Sum of seven skinfolds most likely decreased in the order of 3.1 ± 3.6 mm week-to-week, accompanied by a most likely trivial decrease in body mass of 0.4 ± 0.4 kg week-to-week. At altitude, sleep quality very likely trivially improved week-to-week (0.3 ± 0.3 AU), SpO2 possibly increased week-to-week (0.6 ± 1.7%), whilst changes in resting HR were unclear (0 ± 4 bpm). Sleep duration and USG were stable. Comparing individual to group day-to-day change in monitored variables may prove effective to flag athletes potentially at risk of training maladaptation. Practitioners may replicate these methods to establish thresholds specific to their cohort and setting. This study provides further support for a multi-faceted approach to monitoring elite athletes in training camp environments.