Miracle-dz/UniFAR-FTUs huggingface dataset:
Phishing in email and instant messaging

Phishing is a constantly evolving threat in the world of information security that affects everyone, no matter if you’re a retail worker or the head of IT in a large organisation. Because of this, this thesis aims to give the reader a good overview of what phishing is, and due to its prevalence in email and instant messaging, focuses on educating the reader on common signs and techniques used in phishing in the aforementioned forms of communication. The chosen research method is literature review, as it is the ideal choice for presenting an overview of a larger subject. As a result of the research, many common phishing signs and techniques in both email and instant messaging are presented. Some of these signs include strange senders, fake domain names and spellings mistakes. With this thesis, anyone looking to improve their understanding about phishing can do so in a way that is easy to understand. Some suggestions for future research are also presented based on this thesis’ shortcomings , namely the lack of studies on phishing in instant messaging.
Making Implicit Parameters Explicit

In almost all languages all arguments to functions are to be given explicitly. The Haskell class system however is an exception: functions can have class predicates as part of their type signature, and dictionaries are implicitly constructed and implicitly passed for such predicates, thus relieving the programmer from a lot of clerical work and removing clutter from the program text. Unfortunately Haskell maintains a very strict boundary between the implicit and the explicit world; if the implicit mechanisms fail to construct the hidden dictionaries there is no way the programmer can provide help, nor is he able to override the choices made by the implicit mechanisms. In this paper we describe, in the context of Haskell, a mechanism that allows the programmer to explicitly construct implicit arguments. This extension blends well with existing resolution mechanisms, since it only overrides the default behavior. We include a description of the use of partial type signatures, which liberates the programmer from having to choose between specifying a complete type signature or no type signature at all. Finally we show how the system can easily be extended to deal with higher-order predicates, thus enabling the elegant formulation of some forms of generic programming.
CMAR_A_255866 4747..4758

Department of Laboratory Medicine, The Affiliated Xi’an Centre Hospital of Xi’an Jiaotong University College of Medicine, Xi’an, Shaanxi 710003, People’s Republic of China Background: Colorectal cancer (CRC) is one of the most common malignant tumors in the digestive system. The lncRNA HCP5 has been reported to affect the progression of tumor in several types of cancer. Here, in this research, we focus on the role and function of lncRNA HCP5 in human colorectal cancer. Materials and Methods: Tissue samples from colorectal cancer patients were used for detecting the expression of HCP5 by qRT-PCR. Proliferation, migration, invasion and apoptotic cells were assessed by CCK-8, colony formation, transwell assays and flow cytometry in SW480 andHCT-116 cells. The interactions betweenmiR-299-3p andHCP5 or PFN1were analyzed and confirmed by online database and luciferase reporter assays. The changes in PFN1 and AKT proteins were measured by Western blot. In vivo experiment was used to confirm the role of HCP5 in CRC. Results: The expression of HCP5 had a higher level in colorectal cancer samples and cells by qRT-PCR, comparing with the normal colorectal tissues and human normal colon epithelial cell. It was revealed that knockdown of HCP5 inhibited viabilities, migration and invasion, while inducing apoptosis in SW480 and HCT-116 cells. Then, HCP5 negatively regulated the expressions of miR-299-3p, which negatively regulated the expressions of PFN1 by targeting PFN1. Furthermore, miR-299-3p inhibitor could alleviate the inhibiting effect by si-HCP5 on cell process of SW480 and HCT-116 cells. In addition, the lncHCP5/ miR-299-3p/PFN1 axis could affect the progression of CRC through activating the AKT signaling. Last, we confirmed that knockdown of HCP5 inhibited the progression of CRC with an in vivo experiment. Conclusion: The experiments and analyses support our hypothesis that knockdown of lncRNA HCP5 suppresses the progression of colorectal cancer by miR-299-3p/PFN1/AKT axis.
A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF APPLIED SCIENCE in THE FACULTY OF GRADUATE STUDIES

Residual stresses are “locked-in” within a material, and exist without any external loads. Such stresses are developed during most common manufacturing processes, for example welding, cold working and grinding. These “hidden” stresses can be quite large, and can have profound effects on engineering properties, notably fatigue life and dimensional stability. To obtain reliable and accurate residual stress measurements for uniform and non-uniform stress states, a novel and practical method using crossing-slitting and ESPI is presented here. Cross-slitting releases all three in-plane stress components and leaves nearby deformation areas intact. The ESPI (Electronic Speckle Pattern Interferometry) technique gives an attractive tool for practical use, because measurements provide a large quantity of useful data, require little initial setup and can be completed rapidly and at low per-measurement cost. A new ESPI setup consisting of shutter and double-mirror device is designed to achieve dual-axis measurements to balance the measurement sensitivities of all in-plane stress components. To evaluate data quality, a pixel quality control and correction procedure is also applied. This helps to locate bad data pixels and provides opportunities to correct them. The measurement results show that this procedure plays an important role for the success of residual stress evaluation. Based on the observed displacement data and finite element calculated calibration data, an inverse computation method is developed to recover the residual stresses in a material for both uniform and non-uniform cases. By combining cross-slitting and ESPI, more reliable results for the three in-plane residual stress components can be obtained.
Finger Print Authorized Guard Key Encryption for Network Security

: A Biometric trait Finger print is integrated with cryptographic techniques for more secured authentication. The double encryption techniques make the system more robust in data transmission. Guard key generation as one time password provides high level security to the system. The proposed algorithm enhances security, efficiency, effectiveness and reduces storage overhead, design complexity. It prevents malicious attacks, DoS attacks, data theft and cyber crimes. It protects owners' data privacy without sacrificing the usability and accessibility of the information in large data base.
Compass: A Data Center Bootloader for Software Deﬁned Infrastructure

—In this paper, we present a design of data center deployment automation system, Compass , for bootstrapping a software deﬁned infrastructure, including network and compute nodes. Compass automates the process of bootstrapping a Software-Deﬁned Networking (SDN) -based network from bare-metal networking devices and provisioning the bare-metal servers through the SDN network in a uniﬁed management approach. The uniﬁed and streamlined deployment management of networking and compute resources not only reduces the initial deployment cost, but also provides a way to automatically scale out data center infrastructure’s capacity horizontally after the initial infrastructure setup (e.g., adding networking and computing resources, etc.). Using Compass , we have deployed a private cloud in a medium scale data center with around 200 commodity servers and over 20 SDN switches in Tsinghua University. We present the case study in this paper to illustrate the beneﬁts of Compass as a uniﬁed deployment and management tool in a data center’s software deﬁne infrastructure.
lncRNA PCBP1-AS1 Aggravates the Progression of Hepatocellular Carcinoma via Regulating PCBP1/PRL-3/AKT Pathway

Background: Hepatocellular carcinoma (HCC) is a very belligerent primary liver tumor with high metastatic potential. Aberrant expression of lncRNAs drives tumorous invasion and metastasis. Whether lncRNAs engage mechanisms of liver cancer metastasis remains largely unexplored. Patients and Methods: We collected HCC tissues from the tumors and their adjacent normal samples in the Chinese population and analyzed the levels of lncRNAs by microarray analysis. The gain- and loss-of-function analysis demonstrated that PCBP1-AS1 accelerated tumorous growth and metastasis in vivo and in vitro. Moreover, we used RNA-pulldown assay to show that PCBP1-AS1 physically interacted with polyC-RNA-binding protein 1 (PCBP1); meanwhile, PCBP1-AS1 was indeed detected in RIP with the PCBP1 antibody. Mechanistically, we ﬁ rst explored the relationship between PCBP1-AS1 and PCBP1 in HCC cell lines. Results: Here we show that PCBP1-AS1, identi ﬁ ed by microarray analysis on pre- and postoperative HCC plasma specimens, was highly expressed in human HCC, clinically veri ﬁ ed as a prometastatic factor and markedly associated with poor prognosis in patients with hepatocellular carcinoma. PCBP1-AS1 was negatively related with PCBP1 at the messenger RNA and protein expression levels. PCBP1-AS1 triggered PRL-3 and AKT in HCC tumor cells. Additionally, the double knockout of PCBP1 and PCBP1-AS1 abolished the PCBP1-AS1-induced PRL-3-AKT signalling pathway activation. Conclusion: The upregulation of PCBP1-AS1 enhances proliferation and metastasis in HCC, thus regulating the PCBP1-PRL-3-AKT signalling pathway.
Manufacturing & Service Operations Management The Fut ure of Ret ail Operat ions

Retailing consists of all the activities associated with the selling of goods to the ﬁ nal consumer. In this article, we review the research on retail operations published in Manufacturing & Service Operations Research ( M&SOM ) since 1999. We then discuss the current retail landscape and the new research directions it offers, in which M&SOM can play a prominent role.
PREVENTION OF WHEEL WEAR, A CASE STUDY

This bachelor’s degree project aimed to improve the wheel profile of a rail mounted trolley and determine the cause of wheel failure. The proceedings of this project where modelled after an approach for solving wear problems with an emphasis on designing for sustainability. A case study and root cause analysis (RCA) was performed and the flanged wheels were deemed insufficient for the given heavy-haul system. Possible areas of wheel profile improvement were identified and further researched with multiple literature reviews. Throughout the projects duration several limitations were introduced that reduced the concept testing to exclusively theoretical prediction models. Archard’s model was implemented to predict wear and operating time for the proposed material and wheel tread profile concepts. The wheel flange dimensions were chosen based on recommendations from wheel and rail interference handbooks among other sources. The final wheel and rail profile suggestion improved operating time by approximately 300% and wear resistance by 50% compared to its predecessor. This result was achieved by applying the same theoretical prediction model to both current and suggested profiles. The findings of this project are meant to aid SCA among others in similar cases and additionally highlight the value of product improvement from a technological, sociological, and environmental perspective. ___________________________________
Coordinated Elimination Strategy of Low Order Output Current Distortion for LC-Filtered DFIG System Based on Hybrid Virtual Impedance Method

This paper proposes a coordinated control strategy for the rotor-side converter (RSC) and the grid-side converter (GSC) of an LC-filtered doubly fed induction generator (DFIG) under distorted grid voltage condition, to eliminate the distortion of the total output current (including the stator current, the GSC current, and the filter capacitor current). For an LC-filtered DFIG connected to a distorted grid, the low-order current harmonics can freely flow into the filter capacitor thereby polluting the total output current, even when the stator current and the GSC current are both controlled as sinusoidal. Although this problem can be addressed by measuring the output current or the capacitor current, the extra current sensors are undesired in industrial applications. In this paper, a novel hybrid virtual impedance method is implemented in both the RSC and the GSC, to reshape the parallel impedance of the stator, the GSC and the filter capacitor to nearly infinite for low-order harmonics, thus, the freely flowing output current harmonics can be mitigated. Meanwhile, the low-order current harmonics required by the output current compensation can be flexibly distributed between the stator and the GSC according to their operating conditions, to disperse the side-effects on the drive train and the GSC, thereby better protecting the whole system. The effectiveness of the proposed strategy is theoretically analyzed and verified with both simulation and experiment.
A Review of the Design and Control of Free-Piston Linear Generator

The Free-piston linear generator (FPLG) is a novel energy converter which can generate electrical energy and is regarded as a potential technology for solving the restriction of the short driving range of electric vehicles. Getting rid of the crank and flywheel mechanism, FPLG obtains some advantages of a variable compression ratio, compact size, and highly-efficient power generation. Linear electric machine (LEM) design and piston motion control are two key technologies of FPLG. However, they are currently the main obstacles to the favorable performance of FPLG. LEM being used to drive the piston motion or generate electric energy is an integrated design including a motor/generator. Various types of LEMs are investigated, and suitable application scenarios based on advantages and disadvantages are discussed. The FPLG’s controller is used to ensure stable operation and highly-efficient output. However, cycle-to-cycle variations of the combustion process and motor/generator switching make it difficult to improve the performance of the piston motion control. Comments on the advantages and disadvantages of different piston motion control methods are also given in this paper.
Understanding Emerging Motorcyclist Segments in Crashes using Florida Crash Data and Statewide Survey

The United States experienced a continued sharp increase in motorcycle fatalities between 1997 and 2008, with a 9% average annual increase, which resulted in a rapid doubling of motorcycle fatalities within a decade. After a major decline in both the number of fatalities and the fatality rate between 2008 and 2009, motorcycle fatalities and fatality rates have been fluctuating. It was discovered that the demographics of motorcyclists involved in fatal motorcycle crashes have changed because of an increase in the number of motorcyclists under age 30 and over age 50 during the past 10 years. As a result, motorcyclists in the United States can be clustered into three distinct segments by age in crash experiences. This study used motorcycle crash data in Florida that observed similar demographic changes and explored characteristics of the three segments. Descriptive analyses including Chi-square tests showed that each segment had different crash outcomes and different levels of exposure to common risk factors. Crash injury models were developed to understand variables that increase the level of injury severity in each segment. A statewide survey was completed to explore the sociodemographic characteristics of the three motorcyclist segments in Florida, which often are not available through crash data. Overall, the three motorcycle segments identified in this study have unique riding characteristics and crash outcomes. This is essential information for developing and managing motorcycle safety programs in an effective and efficient manner.
MiR-802 Suppresses Colorectal Cancer Cell Viability, Migration and Invasion by Targeting RAN

Purpose: Colorectal cancer is one of the most malignant tumors in the world, and the incidence is increasing every year. MicroRNAs (miRNA) are small non-coding RNAs that are involved in a variety of physiological or pathological processes. Abnormal expression of microRNA-802 (miR-802) has been demonstrated in various types of cancer. However, the expression and biological role of miR-802 in human colorectal cancer remain largely unknown. Methods: Here, we used quantitative real-time PCR (qRT-PCR) to measure miR-802 expression levels in colorectal cancer tissues and cell lines. Cell Counting Kit-8 (CCK-8) was used to assess the effect of miR-802 on colorectal cancer cell viability. Migration and invasion assays were performed to determine the effect of miR-802 on metastasis of colon tumor cells by transwell analysis. Luciferase activity assays were used to con ﬁ rm the target of miR-802. Results: The results show that miR-802 is signi ﬁ cantly downregulated in colorectal cancer tissues and cell lines. Overexpression of miR-802 profoundly inhibited viability, migration and invasion of colorectal cancer cells. In addition, we have newly discovered that the Ras-associated nucleus (RAN) is a direct target of miR-802 which could reverse the effects induced by miR-802 overexpression in colorectal cancer cells. Conclusion: In conclusion, our study shows that miR-802 is downregulated in colorectal cancer, and overexpression of miR-802 inhibits colorectal cancer cell viability, invasion by directly targeting RAN.
Natural-origin materials for tissue engineering and regenerative medicine

The authors would like to thank to the financial support from the Portuguese Foundation for Science and Technology (FCT) for the fellowship grants of Simone S Silva (SFRH/BPD/112140/2015), Emanuel M Fernandes (SFRH/BPD/96197/2013), Joana-Silva Correira (SFRH/BPD/100590/2014), Sandra Pina (SFRH/BPD/108763/2015), Silvia Vieira (SFRH/BD/102710/2014), “Fundo Social Europeu”- FSE and “ Programa Diferencial de Potencial Humano POPH”, and to the distinction attributed to J.M. Oliveira under the Investigator FCT program (IF/00423/2012). It is also greatly acknowledged the funds provided by FCT through the project EPIDisc (UTAP-EXPL/BBBECT/0050/2014), financed in the Framework of the “International Collaboratory for Emerging Technologies, CoLab”, UT Austin|Portugal Program.
Antigen-Presenting Cells Immunoregulatory Role of IL-10 Secreted by A Transgenic Model to Analyze the

IL-10 is a cytokine secreted by a wide variety of cells type that has pleiotropic stimulatory and suppressive activities on both lymphoid and myeloid cells in vitro. To analyze the consequences of high IL-10 secretion by APCs in immune responses, we produced transgenic mice expressing human IL-10 directed by the MHC class II Ea promoter. Despite alterations in the development of T and B cells, no gross abnormalities were detected in peripheral lymphocyte populations or serum Ig levels. However, when immunized using conditions that give either a Th2-type or a Th1-type response, IL-10 transgenic mice failed to mount a signiﬁcant T or B cell immune response to OVA. IL-10 transgenic mice were also highly susceptible to infection with intracellular pathogens like Listeria monocytogenes or Leishmania major , in contrast to IL-10 transgenic mice, where the transgene was express in T cells. Finally, the recently described stimulatory effect of IL-10 on CD8 1 T cells was conﬁrmed by the ability of IL-10 transgenic mice to limit the growth of immunogenic tumors by a CTL-mediated mechanism. These results demonstrate, that, depending on the type of immune response, IL-10 can mediate immunosuppressive or immunostimulatory activities in vivo. The Journal of Immunology, 1999, 162: 1723–1729.
CIA_A_262209 1587..1598

1Internal Medicine, Geriatry and Therapeutic Unit, AP-HM, Marseille, France;Coordination Unit for Geriatric Oncology (UCOG), PACA West, Marseille, France; 2Aix-Marseille Université, CNRS, EFS, ADES, Marseille, France; 3Pharmacology Department, APHM, Marseille, France; 4Aix-Marseille University, Marseille, France; 5Multidisciplinary Oncology and Therapeutic Innovations Unit, AP-HM, Marseille, France; 6Oncology Unit, APHM, Marseille, France Background: Polymorbidity induces polypharmacy in older patients may lead to potential drug–drug interactions (DDI) which can modify the tolerance and safety of oncological treatments and alter the intended therapeutic effect. The objective of our study was to describe the decision-making process for oncological treatment and related outcomes, in a population of older adults undergoing a comprehensive geriatric assessment (CGA) associated to a comprehensive medication reconciliation (CMR) prior to initiating oncological treatment. Methods: ChimioAge is a prospective observational study conducted between 01/2017 and 07/2018 at Marseille University Hospital and approved by the French National Ethics Committee. It comprised all consecutive patients aged 70 years and over who were referred for a CGA as part of CMR, before initiating systemic treatment. Results: One hundred and seventy-one cancer patients were included. Mean age was 79.2 years, over half had metastatic cancers, 75% had an ECOG performance status zero or one, and two-thirds were independent in daily activities. Two-thirds of the patients had polypharmacy and the CMR identified potential DDI with systemic treatment in 43.3% of patients. Following the CGA, the CMR and the hospital oncologists decision, 30% of the patients received adapted systemic treatment with reduced doses at initiation. They presented fewer toxicities – irrespective of grade and type – than patients who received standard treatment (p<0.001) and had comparable overall survival (Log rank p=0.21). Conclusion: This is one of the first studies to highlight the value in conducting CMR and a CGA simultaneously before initiating systemic treatment in older patients with cancer. These two evaluations could give oncologists decisive information to personalize cancer treatment of older patients and optimize treatment dose to offer the best efficacy and minimize toxicity.
ANOMALY DETECTION FOR DATABASE CONNECTIONS

The project investigates the nature of database connection logs by analysing these logs for potential anomalies. We apply different models to the data in building an ensemble of classifiers that is able to flag potentially anomalous or malicious connections to the database instances within the CERN network. Further, we also utilise this research to shed light on usage patterns within the network in order to better understand the temporal dependencies and implement them in the decision-making process within the CERN system. These models are trained on subsets of a data lake that comprises daily connection logs across all instances of databases on the network. The data lake comprises Javascript Object Notation (JSON) logs that may be visualised using short-term storage, Elasticsearch, Grafana and Kibana or pushed to long-term storage on Hadoop Distributed File Storage (HDFS). We extract subsets of this data and apply models that vary based on different parameters of the data, and enable us to classify the outliers among the dataset as anomalies. The approaches adopted vary based on distance, density, and classification policies. Further, we juxtapose the results of the models against each other in order to understand the distribution of anomalies and eliminate false positives occurring across different evaluative models.