Miracle-dz/UniFAR-FTUs huggingface dataset:
Pharmacologyonline 3 : 175-192 ( 2009 ) Sudaroli and Chatterjee 175 EVALUATION OF WOUND HEALING ACTIVITY OF RED AND WHITE SEED VARIETIES OF ABRUS

Abrus precatorius (Fam: Leguminosae) is a traditional folklore medicinal plant used primarly for the treatment of wound,skin disease and ,cancer. The present study was undertaken to explore the wound healing potential of both red and white seed extracts of Abrus precatorius for the treatment of dermal wounds in rats. Both the extract was screened for its influence on collagenation, wound contraction, period of epithelialization and hydroxyproline content in three wound models incision , excision, and dead space wounds followed by histopathological study. Besides, its influence on oxidative stress (levels of SOD,Catalase,GSH and TBARS) was also determined in 10 day old granulation tissue. The result obtained indicated that APW accelerated pronounced wound contraction, decreased period of epithelialization, reduced wound closure time and decreased rate of granulation tissue formation and increased tensile strength and effect was equipotent as that of standard drug. Histopathological and antioxidant characters of the granulation tissue clearly suggest the therapeutic benefits of APW in the treatment of wound healing thus, justifying the local use of the plant for the treatment of skin diseases. More over APR also tends to treat wounds but at p<0.05 level significane compare to control group and showed delayed effect when compared with APW.
Trust as a Success Factor in International Joint Ventures

International joint ventures (IJVs) in construction often face a highly complex and dynamic environment because, in most instances, they are formed to build large scale engineering projects. One of the primary requirements of actors in such systems is to reduce the environmental complexity. On an organizational level, many IJVs disentangle their responsibilities by functional separation and delegation of work. On a social level, delegation of work requires trust in the capability and willingness of others to perform their duties without supervision. As such, trust is a mechanism that allows us to reach our goals efficiently within this setting. Trust itself is mediated by communication involving symbolic interaction. Especially during the start phase, IJVs in construction are high-pressure environments without established networks. The intent of this article is to describe the research carried out and the conclusions drawn to determine the role of trust under such conditions.
Downregulated miR-585-3p promotes cell growth and proliferation in colon cancer by upregulating PSME3

Background Upregulation of PSME3 and its oncogenic roles have been reported in colon cancer recently. However, the underlying mechanism of PSME3 upregulation remains unknown. Here, we explored the expression of PSME3 and subsequently uncovered its mechanism in colon cancer. Materials and methods The expression of PSME3 was analyzed by using online databases, Oncomine and UALCAN. qPCR was carried out to detect the expression of PSME3 in collected colon cancer tissues and cell lines. Moreover, the promoter methylation and the hnRNA level of PSME3 were also analyzed by online database and qPCR, respectively. The candidate miRNAs targeting PSME3 were predicted by Starbase 3.0 and validated by luciferase reporter system. CCK-8, plate colon formation, and Edu incorporation were applied to study the functions of miRNA in colon cancer. The expression of miRNA and its correlation with PSME3 were detected in colon cancer tissues. Results Oncomine and UALCAN data indicate PSME3 is obviously upregulated in colon cancer tissue samples which is further confirmed in collected colon cancer tissues and cells by qPCR. No significant difference in methylation status promoter of PSME3 was observed between colon and colon cancer tissues. The hnRNA level of PSME3 was comparable between colon epithelial cell and colon cancer cells. miR-585-3p is predicted to directly target PSME3 and is validated by luciferase reporter assay. Then, miR-585-3p downregulation is confirmed and miR-585-3p restoration can suppress cell growth and proliferation by inhibiting PSME3 in colon cancer indicating by CCK-8, plate colon formation, and Edu incorporation. Moreover, negative correlation in expression between miR-585-3p and PSME3 was observed in our collected tissues samples. Conclusion We reveal for the first time that miR-585-3p downregulation accounts for the overexpression of PSME3 in colon cancer. Moreover, miR-585-3p, serving as a tumor suppressor, can inhibit cell growth and proliferation in colon cancer by targeting PSME3.
Effect of Vitamin D Supplementation on Cardiometabolic Factors and Inflammatory Status in Adolescents with Obesity Enrolled in a Weight-Loss Program

Obesity in children is associated with vitamin D (VD) deficiency and cardiometabolic abnormalities. To analyze the effects of VD supplementation in adolescents with obesity enrolled in a weight-loss program. Adolescents with obesity (n=26) and with normal weight (n=23; controls) were matched for age, sex, and puberty stage. The obesity group followed a 3-month weight-loss program that combined a reduced caloric intake with interval training physical activity and during which they received or not VD supplementation (4000 IU/d) (n=13/group; random assignation). The anthropometric parameters (BMI z-score, fat mass); serum levels of 25(OH)D, calcium and parathyroid hormone (PTH), cardiometabolic factors (triglycerides, HDL, and LDL cholesterol), fasting glucose and insulin, and homeostasis model assessment of insulin resistance index; diastolic, systolic and mean blood pressure, and inflammatory status (C-reactive protein, CRP) were measured at baseline and at the end of the 3-month program. At baseline, 25(OH)D concentration was lower and VD insufficiency (25(OH)D levels <50 nmol/L) rate was higher (73% vs 22%) in the obesity than in the normal-weight group. All cardiometabolic factors were altered in the obesity compared with the normal-weight group. After the 3-month weight-loss program, 25(OH)D levels was >50 nmol in all adolescents with obesity, but only in 46% of normal-weight adolescents. Moreover, the weight-loss program improved the cardiometabolic factors, inflammatory status (CRP) and physical performance, but VD supplementation did not have any additional effect. Analysis only of the adolescents with obesity and VD deficiency (25(OH)D <50 nmol/L) at baseline showed a significant correlation between the change in PTH and CRP (p=0.02) in the supplemented obesity group, while the increase in 25(OH)D only tended to be correlated with CRP decrease. Vitamin D supplementation could reduce VD insufficiency in adolescent with obesity, but does not have any additional effect on cardiometabolic factors when combined with a weight-loss program.
The effect of the genetic liability to autism spectrum disorder on emotion recognition in young unaffected probands from a population-based cohort

We investigated how ASD genetic risk relates to neurodevelopmental features (491 traits tested) via polygenic risk scoring (PRS) in 4,309 young non-ASD probands from the Philadelphia Neurodevelopmental Cohort. ASD PRS most strongly associated with the ability to correctly identify angry facial emotions in youths aged 11-17 years (R2=1.06%, p=1.38×10−7) and replicated similarly in older probands (>18 years) (R2=0.55%, p=0.036). The association in 11- to-17-year-old probands was independent of other psychiatric disorders, brain imaging phenotypes, and educational attainment. ASD PRS also associated with proband-reported emotionality and connectedness with others. The proband-reported irritability trait was highly correlated with angry facial emotion recognition (r2=0.159, p=2.74×10−5) but was independently associated with ASD PRS (R2=1.20%, p=1.18×10−4). Several informant-reported (i.e., typically mother-reported) traits were predicted by the proband’s ASD PRS, including duration of fear (R2=0.156%, p=0.001). These data indicate how genetic liability to ASD may influence neurodevelopment in the general population, especially the development of emotional intelligence.
Teachers' education and the Bologna Process: a survey on trends in learning structures at institutions of teachers' education

Needs of national development in all countries, progressing European co-operation and association as well as globalisation have caused in last few years a particular challenge (also) to higher education systems and institutions. The response to this challenge in Europe is widely known today as the Bologna process. Four years after signing the Bologna Declaration (1999) with its six main “action lines”,1 and two years after Prague communique (2001) which added three further “action lines”2 to the list, the process of establishment of the European Higher Education Area (EHEA) deepened to the institutional level.
Fractal Analysis of Deep Ocean Current Speed Time Series

AbstractFractal properties of deep ocean current speed time series, measured at a single-point mooring on the Madeira Abyssal Plain at 1000- and 3000-m depth, are explored over the range between one week and 5 years, by using the detrended fluctuation analysis and multifractal detrended fluctuation analysis methodologies. The detrended fluctuation analysis reveals the existence of two subranges with different scaling behaviors. Long-range temporal correlations following a power law are found in the time-scale range between approximately 50 days and 5 years, while a Brownian motion–type behavior is observed for shorter time scales. The multifractal analysis approach underlines a multifractal structure whose intensity decreases with depth. The analysis of the shuffled and surrogate versions of the original time series shows that multifractality is mainly due to long-range correlations, although there is a weak nonlinear contribution at 1000-m depth, which is confirmed by the detrended fluctuation analysis o.
Electromagnetically driven zonal flows in a rapidly rotating spherical shell

Abstract We consider the flow of an electrically conducting fluid confined in a rotating spherical shell. The flow is driven by a directly imposed electromagnetic body force, created by the combination of an electric current flowing from the inner sphere to a ring-shaped electrode around the equator of the outer sphere and a separately imposed predominantly axial magnetic field. We begin by numerically computing the axisymmetric basic states, which consist of a strong zonal flow. We next compute the linear onset of non-axisymmetric instabilities, and fully three-dimensional solutions up to ten times supercritical. We demonstrate that an experimental liquid-sodium device 50 cm in diameter could achieve and exceed these parameter values.
A sub-quadratic algorithm for the longest common increasing subsequence problem

The Longest Common Increasing Subsequence problem (LCIS) is a natural variant of the celebrated Longest Common Subsequence (LCS) problem. For LCIS, as well as for LCS, there is an $O(n^2)$-time algorithm and a SETH-based conditional lower bound of $O(n^{2-\varepsilon})$. For LCS, there is also the Masek-Paterson $O(n^2 / \log{n})$-time algorithm, which does not seem to adapt to LCIS in any obvious way. Hence, a natural question arises: does any (slightly) sub-quadratic algorithm exist for the Longest Common Increasing Subsequence problem? We answer this question positively, presenting a $O(n^2 / \log^a{n})$-time algorithm for $a = \frac{1}{6}-o(1)$. The algorithm is not based on memorizing small chunks of data (often used for logarithmic speedups, including the "Four Russians Trick" in LCS), but rather utilizes a new technique, bounding the number of significant symbol matches between the two sequences.
Endogenous fertility and cycles in Solow's growth model

It is shown here that the Solow (1956) neo-classical growth paradigm not only explains the "first" stylised fact of economic growth, namely the existence of a globally stable state of balanced growth, but, once endowed with a demographically founded formulation of the labour supply, is also capable to endogenously explain a second main stylised fact of growth, i.e. the generation of globally stable oscillations around the path of balanced growth.
Physiological Risk Profiles and Allostatic Load: Using Latent Profile Analysis to Examine Socioeconomic Differences in Physiological Patterns of Risk

Purpose. The current study sought to expand implications of physiological weathering through the application of latent profile analysis to stress biomarkers to address limitations of traditional allostatic load calculations. Methods. Latent profile analysis was applied biomarkers used in traditional allostatic load metrics to identify physiological risk profiles in the 2007-20010 National Health and Nutritional and Examination Survey. Multinomial logistic regression was used to determine the probability of risk profiles by race/ethnicity, age, gender, and poverty income ratio (PIR). Mean allostatic load score was assessed across each risk profile. Results. Latent profile analysis identified four distinct profiles labeled low risk, inflammatory risk, cardiovascular risk, and hypertension risk. Race, age, and gender significantly increased odds of exhibiting a risk profile. Compared to Whites, Hispanics had significant higher odds of inflammatory (OR=1.43, 95% CI [1.06-1.92]) and cardiovascular risk profiles (OR=1.63, 95% CI [1.09-2.43]) while Blacks had higher odds of inflammatory (OR=1.76 95% CI [1.25-2.47]), cardiovascular (OR=2.12, 95% CI, [1.39-3.27]) and hypertension risk profiles (OR= 1.78, 95% CI [1.21-2.59]). Females held significant greater odds of all risk categories except hypertension in which they held the lowest odds (OR= .19, 95% CI [.14-.25]). Mean allostatic load scores were highest in the inflammatory (M=3.99, SD=1.66) and cardiovascular risk profiles (M=4.4, SD=1.84). Conclusions. Employing latent profile analysis may expand traditional allostatic load methodology by identifying physiological risk patterns among those who experience allostatic load early in life. This may be useful for examining how cultural specific interventions may reduce cardiovascular risk among those exhibiting physiological risk profiles.
Institutional experience of tuberculosis of craniovertebral junction

Background: Craniovertebral junction tuberculosis (CVJ-TB) is a rare entity occurring in only 0.3 to 1% of tuberculous spondylitis. It causes severe instability and neurological deficits. Present study includes 16 cases of CVJ tuberculosis with neck pain and progressive quadriparesis. Radiological evaluation showed wide spread disease around clivus, C1, C2, C3 with extensive bony destruction, cord compression, basilar invagination and atlantoaxial dislocation. Methods: The study included all the cases admitted with cv junction tuberculosis in neurosurgery ward in King George hospital, Visakhapatnam during a period of three years from 2014 to 2016. Four cases were managed conservatively and four cases were treated by only posterior occipitocervical fusion. We performed two stage operation in single sitting i.e. transoral decompression and posterior occipitocervical fusion in 12 cases. The pathological findings confirmed tuberculosis. Results: Postoperatively all the patients had decreased neck pain and two third of the patients (10 of 16 patients) had improvement in motor power. Conclusions: In the available literature, the treatment options offered for cvj-tb have ranged from a purely conservative approach to radical surgery without well-defined guidelines. In this study, we followed a radical approach as the patients included in our study presented with extensive TB cv junction. So, we recommend radical surgery for extensive TB of cv junction.
Stochastic Alternating Direction Method of Multipliers with Variance Reduction for Nonconvex Optimization

In the paper, we study the stochastic alternating direction method of multipliers (ADMM) for the nonconvex optimizations, and propose three classes of the nonconvex stochastic ADMM with variance reduction, based on different reduced variance stochastic gradients. Specifically, the first class called the nonconvex stochastic variance reduced gradient ADMM (SVRG-ADMM), uses a multi-stage scheme to progressively reduce the variance of stochastic gradients. The second is the nonconvex stochastic average gradient ADMM (SAG-ADMM), which additionally uses the old gradients estimated in the previous iteration. The third called SAGA-ADMM is an extension of the SAG-ADMM method. Moreover, under some mild conditions, we establish the iteration complexity bound of $O(1/\epsilon)$ of the proposed methods to obtain an $\epsilon$-stationary solution of the nonconvex optimizations. In particular, we provide a general framework to analyze the iteration complexity of these nonconvex stochastic ADMM methods with variance reduction. Finally, some numerical experiments demonstrate the effectiveness of our methods.
Cytotoxicity Evaluations on Vitex negundo Anti-inflammatory Extracts

Vitex negundo that is locally known as legundi has been used traditionally as tonic, febrifuge and anti-inflammatory medicaments. FRIM already made an attempt to proof its anti-inflammatory activities. V. negundo dichloromethane and ethanolic extracts were scientifically proven for its anti-inflammatory activities through TPA-induced mouse ear oedema assay with percentage of inhibition 72.2% and 54.1 % respectively. Cytotoxicity effects on these anti-inflammatory extracts were evaluated using sulphorhadamine B (SRB) assay on mammary (MCF-7 cell line) and genito-urinary (VERO cell line) systems. Based on WHO 1972, extracts with ICâ‚…â‚€ values less and equal to 20 Âµg/ml can be preliminary considered as cytotoxic. The ICâ‚…â‚€ values of the extracts on both cell lines were more than 50 Âµg/mI. Hence, these anti-inflammatory extracts were not cytotoxic on both mammary and genito-urinary systems teste.
The topological structure of the steady, laminar three-vortex system for a cylinder-flat plate juncture : an experimental investigation

The topological structure of the steady, laminar three-vortex system formed at a cylinder-flat plate juncture has been studied experimentally employing hydrogen bubble flow visualization in a low-speed recirculating water channel. A new type of steady, laminar three-vortex system is identified, which supports recent computational studies. The t1at plate skin-friction patterns corresponding to both the new and to the standard three-vortex topology are found to be equivalent, indicating the non-unique relationship between the wall-limiting streamline pattern and the three-dimensional t10w above the plate. For the new topology, the foremost line of coalescence is a line of attachment rather than a line of separation. This unusual feature illustrates that convergence of skinfriction lines is a necessary, but not sufficient condition indicative of a line of separation. At least three different types of steady, laminar, three-vortex topologies are shown to exist; these are compared and contrasted with previous experimental and computational studies. A unique relationship between the three-vortex topologies has been successfully established based on non-dimensional parameters employing cylinder geometry and boundary layer properties. ~\
Forward Guidance, Pros, Cons and Credibility

The goal of the article is to verify the credibility of time contingent Forward Guidance (FG) as well as its possible time-inconsistency based on the rarely addressed example of the National Bank of Poland (NBP). The NBP’s FG constitutes a unique case study as this measure in its ‘Odyssean’ form was not introduced to overcome the limits of further policy rates cuts. It allowed us to verify the FG’s credibility and time-inconsistency by applying OLS and GMM estimated contemporaneous and forward looking Taylor type rules with interest smoothing. Our empirical evidence reveals that the annual period of FG in Poland was perceived as a credible promise by consumers. We found that time-consistency could have been an additional factor enhancing the considerable credibility of FG. The satisfying results of the NBP’s FG appear to be especially interesting, in particular, when contrasted with the often unfavourable experience with time-contingent FG of prominent central banks. We suppose that to achieve this, the central bank should act with caution and the NBP indeed did so by specifying carefully the short horizon of the commitment to be able to abandon FG when the circumstances change. We also discuss FG by opposing its advantages and the drawbacks indicated in the subject literature.
WORKSITE INTERVENTION TO REDUCE SEDENTARY TIME

WORKSITE INTERVENTION TO REDUCE SEDENTARY TIME. By Mallory Peavler April 4, 2012 Director of Thesis: Dr. Lucas J. Carr, Ph.D. Major Department: Kinesiology Background: Prevalence of sedentary occupations is on the rise and sedentary time is independently associated with an increased risk for chronic diseases. Interventions conducted in the work site have potential for reducing prolonged bouts of sedentary time amongst employees working in sedentary jobs. The purpose of this study was to test the efficacy of a 12-week, worksite intervention for reducing time spent sedentary amongst full-time, sedentary employees. Methods: Forty, full-time, sedentary, employees working at desk dependent jobs were randomized to either: 1) an intervention group (N=23; 47.6+9.9 yrs; 94.1% female; 33.2+4.5 kg/m); 2) or wait list control group (N=17; 42.6+8.9 yrs; 86.9% female; 31.7+4.9 kg/m). Participants in the 12-week intervention group received an under the desk, portable pedal exercise machine, a pedometer, and access to an internet-based program designed to improve self-efficacy, self-monitoring and social support for physical activity. Time spent sedentary was measured objectively by a StepWatch activity monitor. Results: The intervention group significantly reduced daily minutes sedentary time (P<0.01) and percent daily time spent sedentary (P=0.03) compared to the control group from baseline to 12 weeks. The intervention group also significantly increased percent daily time spent in moderate intensity activity (P=0.04) compared to the control group. Conclusions: Findings from this study suggest that the intervention was efficacious at reducing time spent sedentary amongst full-time sedentary employees. These findings are significant due to the growing number of sedentary jobs in the U.S. and the potential of for this technology to be implemented in large-scale work site health programs. WORKSITE INTERVENTION TO REDUCE SEDENTARY TIME