Miracle-dz/UniFAR-FTUs huggingface dataset:
Hand Measurement System Based on Haptic and Vision Devices towards Post-Stroke Patients

Diagnostics of a hand requires measurements of kinematics and joint limits. The standard tools for this purpose are manual devices such as goniometers which allow measuring only one joint simultaneously, making the diagnostics time-consuming. The paper presents a system for automatic measurement and computer presentation of essential parameters of a hand. Constructed software uses an integrated vision system, a haptic device for measurement, and has a web-based user interface. The system provides a simplified way to obtain hand parameters, such as hand size, wrist, and finger range of motions, using the homogeneous-matrix-based notation. The haptic device allows for active measurement of the wrist’s range of motion and additional force measurement. A study was conducted to determine the accuracy and repeatability of measurements compared to the gold standard. The system functionality was confirmed on five healthy participants, with results showing comparable results to manual measurements regarding fingers’ lengths. The study showed that the finger’s basic kinematic structure could be measured by a vision system with a mean difference to caliper measurement of 4.5 mm and repeatability with the Standard Deviations up to 0.7 mm. Joint angle limits measurement achieved poorer results with a mean difference to goniometer of 23. 6º. Force measurements taken by the haptic device showed the repeatability with a Standard Deviation of 0.7 N. The presented system allows for a unified measurement and a collection of important parameters of a human hand with therapist interface visualization and control with potential use for post-stroke patients’ precise rehabilitation.
Relating OpenGL Imaging Process with Exterior and Interior Parameters of Photogrammetry

This paper focuses on bridging the imaging architecture of OpenGL and photogrammetry analytic theory. Firstly, the imaging mechanism of OpenGL has been analysed in the light of projective geometry, and the relationship between exterior and interior parameters in photogrammetry and image matrix in OpenGL has been summarized. Then, the transition equations of two imaging processes are inferred, and a set of equations that conform the perspective imaging matrix are built. By the experiment of simulation of real camera imaging process in OpenGL, the consistency of collinear equation in photogrammetry and perspective imaging mechanism in OpenGL is validated, which will pave the way for the usage of OpenGL. In this experiment, a CCD camera has been used. Firstly, several images of a industry part have been taken by this camera. Then the exterior and interior parameters of these images have been calibrated and these parameters have been input into our OpenGL program to produce corresponding imaging matrix. The experimental results show the reliability and correctness of derivation.
Studies on the Transient Behavior and Dispatching Strategy of Power System Integrated With Large Scale Wind Farms

The dynamic model of induction wind generators and the dynamic stability analysis method of power system with wind farms were presented,the engineering application was realized through the integration of the model and the method with the power system analysis software widely used in China. Combining a typical example,the transient behavior of the power system integrated with a large scale wind farm was analyzed and a concept of Security Capacity of the Wind Farm is given forward considering the condition to guarantee the security and stability of both the power system and the wind farm. Some strategies,for example,the control of power factor of the load,the application of dynamic reactive power compensator,strengthening of the grid and tripping of the wind turbines after the fault were studied to improve the transient behavior and enhance the Security Capacity of the Wind Farm. A dispatching strategy was brought forward by calculating the relationship among operable capacity,dispatchable power and wind velocity. The penetration of wind power can be increased through the application of this dispatching strategy.
Overexpression of miRNA-93-5p Promotes Proliferation and Migration of Bladder Urothelial Carcinoma via Inhibition of KLF9

We focused on studying the effects of a key miRNA-mRNA axis in bladder urothelial carcinoma (BUC). Firstly, miRNAs and mRNAs differentially expressed in BUC were analyzed. Clinical information in the TCGA database was used for survival analysis, and the regulator of miRNA-93-5p was predicted. miRNA-93-5p and KLF9 mRNA expression were detected by qRT-PCR. Protein level detection and targeting measurement were, respectively, achieved by western blot and dual-luciferase approaches. The proliferative, invasive, and migratory abilities were tested through CCK-8, Transwell, and wound healing methods. Cell apoptosis in each group was detected through flow cytometry. As discovered, miRNA-93-5p level was markedly high in BUC cells while KLF9 expression was remarkably low. miRNA-93-5p overexpression promoted BUC cell abilities. Besides, miRNA-93-5p inhibited KLF9 expression. Furthermore, KLF9 overexpression dramatically attenuated such promotion on cancer cell abilities. On the whole, miRNA-93-5p/KLF9 axis facilitated BUC progression, offering a new potential target for BUC patients.
Micro-Osteoperforations Induce TNF-α Expression and Accelerate Orthodontic Tooth Movement via TNF-α-Responsive Stromal Cells

Micro-osteoperforations (MOPs) have been reported to accelerate orthodontic tooth movement (OTM), and tumor necrosis factor (TNF)-α has been reported to play a crucial role in OTM. In this report, the influence of MOPs during OTM was analyzed. We evaluated the expression of TNF-α with and without MOPs by RT-PCR analysis. A Ni-Ti closed coil spring was fixed between the maxillary left first molar and the incisors as an OTM mouse model to move the first molar in the mesial direction. MOPs were prepared on the lingual side and mesial side of the upper first molars. Furthermore, to investigate the target cell of TNF-α for osteoclast formation during OTM with MOPs in vivo, we created four types of chimeric mice in which bone marrow of wild-type (WT) or TNF receptor 1- and 2-deficient mice (KO) was transplanted into lethally irradiated WT or KO mice. The results showed that MOPs increased TNF-α expression, the distance of tooth movement and osteoclast formation significantly. Furthermore, mice with TNF-α-responsive stromal cells showed a significant increase in tooth movement and number of osteoclasts by MOPs. We conclude that MOPs increase TNF-α expression, and tooth movement is dependent on TNF-α-responsive stromal cells.
Evaluating the Waterlogging Tolerance of Wheat Cultivars during the Early Growth Stage Using the Comprehensive Evaluation Value and Digital Image Analysis

The accurate and efficient screening of waterlogging-tolerant cultivars is an effective way to mitigate waterlogging damages. An experiment was conducted to evaluate the performance of 28 wheat varieties mainly planted in the middle and lower reaches of the Yangtze River, China, under control and waterlogging conditions. When the 15-day waterlogging that was initiated at the third-leaf stage was completed, the aboveground dry weight, plant height, leaf number on main stem, culm number, leaf area, and SPAD readings of wheat seedlings were significantly decreased by 14%, 11%, 6%, 13%, 14%, and 15% compared with the control treatment (maintaining approximately 80% of field capacity), respectively. The results showed that the percentage reductions in the dry weight and leaf area under stress accurately represented the influence of the majority of the measured agronomic traits and were significantly negatively correlated with the respective dry weight and leaf area of different cultivars under waterlogging. This suggests that dry weight and leaf area can be used as agronomic traits for screening waterlogging-tolerant cultivars. The comprehensive evaluation value of waterlogging tolerance (CEVW) was closely related to the percentage reduction in dry weight, plant height, culm number, leaf area, and SPAD reading. The range of CEVW was 0.187–0.819, indicating a wide variation in the waterlogging tolerance of the wheat cultivars. Comparing the top-view images, the phenotypic texture parameters (dissimilarity, homogeneity, and angular second moment (ASM)) extracted from the side-view images better reflected the dry weight, plant height, and leaf area under different water treatments. The percentage reduction in ASM had the strongest correlation with CEVW (root mean square error = 0.109); thus, the ASM is recommended as a suitable phenotypic parameter to evaluate waterlogging tolerance. The present results provide references for the rapid and intelligent screening of waterlogging-tolerant wheat cultivars, but future studies need to consider the stress evaluation of the adult plants.
Construction of a Forest Ecological Network Based on the Forest Ecological Suitability Index and the Morphological Spatial Pattern Method: A Case Study of Jindong Forest Farm in Hunan Province

Human activities and climate change have resulted in an increasing fragmentation of forest landscapes, and the conflict between biodiversity protection and economic development has become more pronounced. The establishment of forest ecological networks can be a vital part of biodiversity conservation and sustainable forest development. Using Jindong Forest Farm as the study area, this study combines the forest ecological suitability index, morphological spatial pattern analysis, the area method, and the landscape connectivity index (PC, IIC). This will identify ecological source areas in the study area, extract ecological corridors using the minimum cumulative resistance model and the gravity model, and construct a forest ecological network with ecological source areas as points and ecological corridors as edges. This study identified 11 forest patches in highly suitable habitat regions as ecological source regions, and 54 potential corridors were extracted. The study’s results show that a careful analysis of the forest landscape’s ecological suitability and morphological spatial pattern provides a scientific method for the rational selection of ecological source regions and serves as a reference for protecting forest species diversity and sustainable forest development.
Immunogenicity of the Xcl1-SARS-CoV-2 Spike Fusion DNA Vaccine for COVID-19

SARS-CoV-2 spike (S) variants that may evade antibody-mediated immunity are emerging. Evidence shows that vaccines with a stronger immune response are still effective against mutant strains. Here, we report a targeted type 1 conventional dendritic (cDC1) cell strategy for improved COVID-19 vaccine design. cDC1 cells specifically express X-C motif chemokine receptor 1 (Xcr1), the only receptor for chemokine Xcl1. We fused the S gene sequence with the Xcl1 gene to deliver the expressed S protein to cDC1 cells. Immunization with a plasmid encoding the S protein fused to Xcl1 showed stronger induction of antibody and antigen-specific T cell immune responses than immunization with the S plasmid alone in mice. The fusion gene-induced antibody also displayed more powerful SARS-CoV-2 wild-type virus and pseudovirus neutralizing activity. Xcl1 also increased long-lived antibody-secreting plasma cells in bone marrow. These preliminary results indicate that Xcl1 serves as a molecular adjuvant for the SARS-CoV-2 vaccine and that our Xcl1-S fusion DNA vaccine is a potential COVID-19 vaccine candidate for use in further translational studies.
Risk factors associated with Salmonella prevalence, its antibiotic resistance, and egg antibiotic residues in the layer farming environment

Background and Aim: Human salmonellosis with non-typhoidal Salmonella remains a global public health concern related to the consumption of contaminated eggs and egg-based products. This study aimed to examine the prevalence of Salmonella, antimicrobial-resistant Salmonella, and egg antibiotic residues concerning risk factors associated with Salmonella contamination in eggs, the layer farming environment, and laying hens kept in battery-cage closed-housing systems. Materials and Methods: This study used a repeated cross-sectional design to collect 488 samples from eggs, laying hens, and the farm environment on one laying farm for Salmonella detection according to ISO 6579:2002/AMD 1:2007. Salmonella-positive samples were further tested for serotype and antimicrobial susceptibility using the disk diffusion test. The layer farm contact person was interviewed at the sampling time to evaluate the risk factors associated with Salmonella contamination using logistic regression analysis. For each month, 24 eggs (144 eggs in total) were also randomly sampled from the collection egg area at the farm for antibiotic residue detection using the European Four Plate Test. Results: The highest Salmonella prevalence rates were in the samples from the layer pen floors, followed by the egg sizing machine (ESM) and eggshells at 65.5%, 52.5%, and 15%, respectively. Salmonella enterica serovar Corvallis was the dominant serovar (48.38%), followed by Mbandaka (37.76%), Braenderup (14.29%), and Typhimurium (4.08%). Rodent presence at the farm and the frequency of changing the disinfectant foot dip were significant factors related to Salmonella contamination on the pen floors (odds ratio [OR]=22.5, 95% confidence interval [CI]=2.11-240.48, p=0.01; OR=24, 95% CI=2.78-206.96, p=0.004, respectively). Hand-washing before sorting and cleaning the ESM were the significant factors (OR=13, 95% CI=1.2-140.73, p=0.04). The most resistant Salmonella isolates were resistant to oxytetracycline. One isolate of S. enterica Typhimurium was resistant to cefotaxime, enrofloxacin, and oxytetracycline. The antibiotic residues in the egg yolks were streptomycin, enrofloxacin, and tetracycline at prevalence rates of 36.11%, 11.81%, and 7.64%, respectively. Streptomycin was the most abundant residue in the albumen and yolk, followed by tetracycline. Conclusion: Salmonella prevalence in layer farming with a closed-housing system is related to effective biosecurity and hygiene issues, such as rodent control, clean farm equipment, and good worker hygiene. In addition, eggs’ antibiotic residues may be related to treating antimicrobial-resistant Salmonella isolates and medicated feed with inappropriate antibiotic withdrawal time.
Visual Simulation Technology Based on OpenGL

The visual simulation technology is a new type simulating technology which includes PC visualization and system simulation. One of the most important applications is designing dummy battlefield environment for training army, and it not only can save military expenditure, but also can be reused. The article introduces the importance of visual simulation in some domains, and expatiates the important contents ( original data, environment background, simulation process, simulation output and viewport ramble) of visual simulation,and introduces the realization of all aspects briefly. Besides,the paper linking with the certain missile simulator and aiming at the most important and difficult content in visual simulation - environment background expatiates how to render the battlefield environment with OpenGL and LOD, and gives the result of the rendered scene finally.
GM-CSF Protects Macrophages from DNA Damage by Inducing Differentiation

At inflammatory loci, pro-inflammatory activation of macrophages produces large amounts of reactive oxygen species (ROS) that induce DNA breaks and apoptosis. Given that M-CSF and GM-CSF induce two different pathways in macrophages, one for proliferation and the other for survival, in this study we wanted to determine if these growth factors are able to protect against the DNA damage produced during macrophage activation. In macrophages treated with DNA-damaging agents we found that GM-CSF protects better against DNA damage than M-CSF. Treatment with GM-CSF resulted in faster recovery of DNA damage than treatment with M-CSF. The number of apoptotic cells induced after DNA damage was higher in the presence of M-CSF. Protection against DNA damage by GM-CSF is not related to its higher capacity to induce proliferation. GM-CSF induces differentiation markers such as CD11c and MHCII, as well as the pro-survival Bcl-2A1 protein, which make macrophages more resistant to DNA damage.
Development and Validation of a New Home Cooking Frequency Questionnaire: A Pilot Study

Home cooking and the type of cooking techniques can have an effect on our health. However, as far as we know, there is no questionnaire that measures in depth the frequency and type of cooking techniques used at home. Our aim was to design a new Home Cooking Frequency Questionnaire (HCFQ) and to preliminarily assess its psychometric properties. For this purpose we used a five-phase approach, as follows: Phase 1: item generation based on expert opinion, relevant literature and previous surveys; Phase 2: content validity assessed by experts for relevance and clarity (epidemiologists, dietitians, chefs); Phase 3: face validity and inter-item reliability; Phase 4: criterion validity using a 7-day food and culinary record; and Phase 5: test stability and inter-item reliability. The content validity index for scale and item level values provided evidence of the content validity for relevance and clarity. Criterion validity analysis showed intraclass correlation coefficients ranged from 0.31–0.69. Test–retest reliability coefficients ranged from 0.49–0.92, with ƙ values > 0.44. Overall Cronbach’s alpha was 0.90. In conclusion, the HCFQ is a promising tool with sound content and face validity, substantial criterion validity, and adequate reliability. This 174-item HCFQ is the first questionnaire to assess how often people cook and which cooking methods they use at home.
What are the causes of small business failure in Burao, Somaliland?

Small business failure has been a wider problem in Somaliland in general and Burao in particular for years. Therefore, this study was conducted to identify internal and external causes that contribute to small business failure in Burao, Somaliland. This study was a survey research in which questionnaires were used to collect data from 200 respondents who were owners of failed small businesses. The data was analyzed using descriptive statistical tools with help of SPSS 21. Moreover, Relative Importance Index (RII) was employed to ascertain the most significant internal and external factors that cause small business failure in Burao, Somaliland. With regard to factors caused failure of the small businesses, the study found that the most powerful internal causes were: Lack of consultation with experienced and professional business people; ineffective advertising or promotional strategy; poor business site location; lack of knowledge of current business situation, lack of specific target market. Furthermore, the study exposed that the most significant external causes that brought small business failure were: poor economic conditions; high operating expenses like rents and wages, higher competition.
Depression among Korean men during COVID-19: social media and physical activity

Background: Due to the COVID-19 pandemic, Korean men are withdrawing from social interactions and feeling depressed due to financial difficulties. This depression can be reduced through physical activities and use of social media for communication. Therefore, this study aims to examine activities effective in reducing depression by analyzing the differences in physical activities and levels of social media addiction, depending on the level of depression. Methods: A total of 591 Korean males affected by the COVID-19 pandemic participated in the study. Results were extracted by frequency analysis, descriptive statistical analysis, chi-square test, and t-test using SPSS 25.0 (IBM Corp., Armonk, NY, USA). Results: Chi-square test, which analyzed differences in demographic characteristics based on the level of depression, revealed significant differences in monthly average family incomes, levels of participation in physical leisure activities, extent of social media usage and kinds of social media used. Significant differences existed in high-intensity physical activities as well as social media non-addiction and addiction depending on the level of depression. Conclusions: Since COVID-19 is increasing depression in males, government or health-related institutes need to provide spacious areas to engage in physical activities, which may help reduce suicidal ideation and restore mental health in Korean males. Moreover, there is a need to develop diverse health-related social media contents, which can help reduce depression. Thus, it has been thought that places to perform physical activities and sufficient communication with others on social media can prove helpful in managing depression.
Genome-Wide Identification and Characterization of the Shaker-Type K+ Channel Genes in Prunus persica (L.) Batsch

Shaker-type K+ channels are critical for plant K+ acquisition and translocation that play key roles during plant growth and development. However, molecular mechanisms towards K+ channels are extremely rare in fruit trees, especially in peach. In this study, we identified 7 putative shaker-type K+ channel genes from peach, which were unevenly distributed on 5 chromosomes. The peach shaker K+ channel proteins were classified into 5 subfamilies, I-V, and were tightly clustered with pear homologs in the phylogenetic tree. Various cis-acting regulatory elements were detected in the promoter region of the shaker-type K+ channel genes, including phytohormone-responsive, abiotic stress-responsive, and development regulatory elements. The peach shaker K+ channel genes were expressed differentially in distinct tissues, and PpSPIK was specifically expressed in the full-bloom flowers; PpKAT1 and PpGORK were predominantly expressed in the leaves, while PpAKT1, PpKC1, and PpSKOR were majorly expressed in the roots. The peach shaker K+ channel genes were differentially regulated by abiotic stresses in that K+ deficiency, and ABA treatment mainly increased the shaker K+ channel gene expression throughout the whole seedling, whereas NaCl and PEG treatment reduced the shaker K+ channel gene expression, especially in the roots. Moreover, electrophysiological analysis demonstrated that PpSKOR is a typical voltage-dependent outwardly rectifying K+ channel in peach. This study lays a molecular basis for further functional studies of the shaker-type K+ channel genes in peach and provides a theoretical foundation for K+ nutrition and balance research in fruit trees.