Miracle-dz/UniFAR-FTUs huggingface dataset:
“Lift Big–Get Big”: The Impact of Images of Hyper-Muscular Bodies and Training Information

ABSTRACT Purpose: It has been suggested that the media influence beliefs regarding ideal body appearance and drive for muscularity whilst also offering recommendations for achieving this; most commonly heavy load free weight resistance training (RT). However, evidence for media effects are inconsistent in the literature. This study investigated this “lift big–get big” culture and effects of imagery on males’ beliefs regarding RT. Method: An online survey was conducted with male participants (N = 110) randomized to different images (hyper-muscular/lean/control) and RT information (“lift big–get big”/“evidence based RT”/control). Results: Descriptive data suggested belief in necessity of heavy loads and free weights was pervasive. There was a small significant effect of condition for multivariate analysis of beliefs regarding RT. Univariate analyses showed significant effects of condition regarding the importance of free weights and heavy loads for strength, and free weights for hypertrophy. Small to moderate effects were found comparing “evidence-based RT” with a hyper-muscular physique to “lift big–get big” conditions with both hyper-muscular and lean physiques, the latter more likely to agree free weights and heavy loads are necessary for strength. A small effect was found comparing “lift big–get big” conditions with both hyper-muscular and lean physiques and the control condition, the former more likely to agree free weights are necessary for hypertrophy. Conclusions: Although hyper-muscular bodies alone did not influence RT beliefs, new information, i.e., “evidence-based RT” combined with a hyper-muscular physique had a small effect. The “lift big–get big” culture is perhaps pervasive enough that most conditions merely reinforced existing beliefs.
Chemical, Physical and Biological Triggers of Evolutionary Conserved Bcl-xL-Mediated Apoptosis

Background: The evidence that pan-Bcl-2 or Bcl-xL-specific inhibitors prematurely kill virus-infected or RNA/DNA-transfected cells provides rationale for investigating these apoptotic inducers further. We hypothesized that not only invasive RNA or DNA (biological factors) but also DNA/RNA-damaging chemical or physical factors could trigger apoptosis that have been sensitized with pan-Bcl-2 or Bcl-xL-specific agents; Methods: We tested chemical and physical factors plus Bcl-xL-specific inhibitor A-1155463 in cells of various origins and the small roundworms (C. elegans); Results: We show that combination of a A-1155463 along with a DNA-damaging agent, 4-nitroquinoline-1-oxide (4NQO), prematurely kills cells of various origins as well as C. elegans. The synergistic effect is p53-dependent and associated with the release of Bad and Bax from Bcl-xL, which trigger mitochondrial outer membrane permeabilization. Furthermore, we found that combining Bcl-xL-specific inhibitors with various chemical compounds or physical insults also induced cell death; Conclusions: Thus, we were able to identify several biological, chemical and physical triggers of the evolutionarily conserved Bcl-xL-mediated apoptotic pathway, shedding light on strategies and targets for novel drug development.
Amphibians and Nonmarine Turtles from the Miocene Calvert Formation of Delaware, Maryland, and Virginia (USA)

Abstract Two amphibian taxa are reported for the first time from the lower to middle Miocene shallow-marine Calvert Formation. These are Batrachosauroides aff. B. dissimulans (a large proteoid salamander) and cf. Notophthalmus robustus (a small newt). Four kinds of identifiable nonmarine turtles were reported previously from this formation. These are Bairdemys miocenica (a pleurodire), Kinosternon sp. (a musk turtle), Hesperotestudo ducateli and Hesperotestudo wilsoni (tortoises). Four additional taxa reported here are Chrysemys isoni n. sp. (a painted turtle), Trachemys sp. (a pond turtle), Floridemys hurdi n. sp. (a small tortoise), and Apalone lima (a softshell turtle). Most of these taxa are known from elsewhere in the Atlantic and Gulf Coastal Plains from New Jersey to Texas. The regional widespread occurrence of many of these taxa indicates that they represent a modestly diverse community of amphibians, fresh water turtles, and land turtles that were endemic to the Atlantic and Gulf coastal regions of the United States during the late early and early middle Miocene. Their pattern of distribution is similar to that of eastern American land mammals during this time interval, indicating that the Atlantic and Gulf coastal plains of the southeastern United States then lay within a single climatic zone that constituted a distinctive and long-lived faunal province throughout the early and middle Miocene (Hemingfordian through Barstovian land mammal ages).
Behavioral responses of Diaphorina citri to host plant volatiles in multiple-choice olfactometers are affected in interpretable ways by effects of background colors and airflows

In several phytophagous hemipterans, behavior appears to be mediated by both visual and chemical cues. For the Asian citrus psyllid (ACP) Diaphorina citri (Hemiptera: Liviidae), olfactometric assays are generally difficult to interpret owing to the low proportion of individuals responding to odors (~30–40%), which compromises the efficiency and reliability of the results of behavioral tests. In the present study, the ACP behavioral response to emitted odors from sweet orange (Citrus sinensis L. Osbeck) flushes in a 4-arm olfactometer using different colors (four white-, two white- and two yellow- on opposite sides, or four yellow-colored fields), and the role of the airflow in the concentration of volatile organic compounds (VOCs) were assessed at two airflows [0.4 and 0.1 L/min (LPM)]. Exposure to ‘Pera’ sweet orange or clean air in treatments with four yellow-colored-fields increased the response rate of ACP females to the odor sources compared with exposure to ‘Pera’ sweet orange or clean air in treatments with four white-colored-fields, independently of the odor source and airflow tested. For the assays using two white- and two yellow-colored fields on opposite sides and 0.4 or 0.1 LPM airflow, the residence time of ACP females to odors (‘Pera’ sweet orange or clean air) was similar or higher in treatments using yellow- than those using white-colored fields. For both assays (VOCs and olfactometric behavioral parameters), the reduction in airflow from 0.4 to 0.1 LPM greatly changed the airborne concentration and ACP behavior. Quantitative chemical analyses revelead that the concentration of most compounds emitted by ‘Pera’ sweet orange flushes for the headspace using 0.1 LPM airflow were greater than the concentrations measured using 0.4 LPM airflow. Therefore, this treatment design provides an useful tool to assess the ACP behavioral response to the odors from citrus plants, and it can also help in the discrimination of dose-response screenings for VOCs or conspecific insects.
Are Household Expenditures on Food Groups Associated with Children’s Future Heights in Ethiopia, India, Peru, and Vietnam?

Household expenditure surveys, routinely conducted in low—and middle-income countries (LMICs), usually include questions pertaining to recent household expenditures on key food groups. When child anthropometrics are also available, such expenditure data can provide insights into household food purchasing patterns that are associated with subsequent child growth measures. We used data from 6993 children, born around 2001, from Ethiopia, India, Peru, and Vietnam, from the Young Lives younger cohort. We compared associations between two weeks of household food expenditures (in PPP—Purchasing Power Parity adjusted dollars) on food groups and child height-for-age-Z score (HAZ) at subsequent time points to assess longitudinal associations. Total food expenditures, rural/urban residence, maternal and paternal schooling, and child sex were included in our adjusted models because they may affect the relations between household food group expenditures and future child HAZ. In Ethiopia, India, and Peru every extra PPP$ spent on fats was associated with 0.02–0.07 higher future HAZ. In Vietnam every extra PPP$ spent on starches, was significantly associated with a 0.01 lower future HAZ. Across countries, different patterns of food expenditure and procurement may be differentially critical for predicting child HAZ. Our results demonstrate how expenditures on specific food groups can be associated with children’s linear growth. This study provides additional evidence of the utility of longitudinal household food expenditure data in understanding child nutritional status.
Dyadic Exploration of the Relationship of Leisure Satisfaction, Leisure Time, and Gender to Relationship Satisfaction

Despite a substantial amount of leisure research, little is known about the leisure activity patterns and satisfaction of couples and their influence, if any, on relationship satisfaction. Further, satisfaction and leisure activity research has been limited to married dyads and has not included a range of romantic partners. Leisure research has focused primarily on individual data, and this impedes fully understanding the joint construction of leisure in a couple and its outcomes. The present research extends efforts by examining the perceptions of dyads in diverse relationships and their effect on their leisure and relationship satisfaction. The model in this study is that gender, joint leisure time, and individual leisure satisfaction affect the relationship satisfaction of both an individual and his or her partner: the partner effect model. Questionnaires self-administered to both members of romantic dyads obtained information on the variables of interest. Results indicated moderate participant leisure satisfaction and a near-significant relationship between gender and relationship satisfaction. However, the model that individual leisure satisfaction would influence both an individual and a partner's relationship satisfaction was not supported by the data. Nonetheless, dyadic research remains a rich area for conceptual and methodological advancement, and therefore subsequent research suggestions are presented.
Respiration of the Roots of Flood-Tolerant and Flood-Intolerant Senecio Species: Affinity for Oxygen and Resistance to Cyanide

The affinity of respiration for oxygen in the roots of six Senecio species studied was low compared with the affinity of cytochrome oxidase for oxygen. Half saturation values of approximately 22 μM oxygen were measured. Root respiration was to a large extent insensitive to cyanide in flood-tolerant as well as in flood-sensitive species. The evidence presented suggests that high activity of salicylhydroxamic acid (SHAM)-sensitive oxidase in Senecio roots was the basis for the low oxygen affinity and for the high cyanide-insensitivity of root respiration in the Senecio species. Methods are described to determine the in vivo activity of the SHAM-sensitive oxidase. It was estimated that it contributed 70% to the total root respiration. The presence of SHAM-sensitive oxidase activity could explain a higher efficiency of root growth respiration under a low oxygen tension if this alternate oxidase was inhibited at a low oxygen concentration in the root medium. However, the SHAM-sensitive oxidase was not specifically involved in either growth respiration or maintenance respiration. Its significance in regulation of the redox state of the cells is discussed.
Development of a Nonwoven Hemostatic Dressing Based on Unbleached Cotton: A De Novo Design Approach

Minimally processed greige (unbleached) cotton fibers demonstrate enhanced clotting relative to highly processed United States Pharmacopeia (USP) type 7 bleached cotton gauze. This effect is thought to be due to the material surface polarity. We hypothesized that a textile could be constructed, conserving the hemostasis-accelerating properties of greige cotton, while maintaining structural integrity and improving absorbance. Spun bond nonwovens of varying surface polarity were designed and prepared based on ratios of greige cotton/bleached cotton/polypropylene fibers. A thromboelastographic analysis was performed on fibrous samples in citrated blood to evaluate the rate of fibrin and clot formation. Lee White clotting times were obtained to assess the material’s clotting activity in platelet fresh blood. An electrokinetic analysis of samples was performed to analyze for material surface polarity. Hemostatic properties varied with composition ratios, fiber density, and fabric fenestration. The determinations of the surface polarity of cotton fabrics with electrokinetic analysis uncovered a range of surface polarities implicated in fabric-initiated clotting; a three-point design approach was employed with the combined use of thromboelastography, thrombin velocity index, Lee White clotting, and absorption capacity determinations applied to fabric structure versus function analysis. The resulting analysis demonstrates that greige cotton may be utilized, along with hydrophilic and hydrophobic fibers, to improve the initiation of fibrin formation and a decrease in clotting time in hemostatic dressings suitable to be commercially developed. Hydroentanglement is an efficient and effective process for imparting structural integrity to cotton-based textiles, while conserving hemostatic function.
Consumption of a High-Fat Breakfast on Consecutive Days Alters the Area-under-the-curve for Selected CVD Biomarkers

Background: One of the primary causes of obesity-associated disease is the habitual consumption of a high-fat, high-calorie diet. The purpose of this study was to determine the effect of consumption of a high-fat, high-calorie breakfast on consecutive days on the area under the curve (AUC) for 22 emerging cardiovascular disease (CVD) biomarkers in young women (N=8). Material and Methods: Subjects consumed a high-fat (70% of daily calories, 100% of daily fat) breakfast meal on two consecutive days. Blood samples were collected pre-meal, 1h, 2h, 3h, 4h, and 5h post-meal. Cholesterol, triglycerides, and glucose were measured using an enzymatic assay. CVD biomarkers were analyzed simultaneously in serum using a multiplex method and AUC was calculated separately for each biomarker on each day. A paired t-test with significance set at P
A mm-Sized Free-Floating Wireless Implantable Opto-Electro Stimulation Device

Towards a distributed neural interface, consisting of multiple miniaturized implants, for interfacing with large-scale neuronal ensembles over large brain areas, this paper presents a mm-sized free-floating wirelessly-powered implantable opto-electro stimulation (FF-WIOS2) device equipped with 16-ch optical and 4-ch electrical stimulation for reconfigurable neuromodulation. The FF-WIOS2 is wirelessly powered and controlled through a 3-coil inductive link at 60 MHz. The FF-WIOS2 receives stimulation parameters via on-off keying (OOK) while sending its rectified voltage information to an external headstage for closed-loop power control (CLPC) via load-shift-keying (LSK). The FF-WIOS2 system-on-chip (SoC), fabricated in a 0.35-µm standard CMOS process, employs switched-capacitor-based stimulation (SCS) architecture to provide large instantaneous current needed for surpassing the optical stimulation threshold. The SCS charger charges an off-chip capacitor up to 5 V at 37% efficiency. At the onset of stimulation, the capacitor delivers charge with peak current in 1.7–12 mA range to a micro-LED (µLED) array for optical stimulation or 100–700 μA range to a micro-electrode array (MEA) for biphasic electrical stimulation. Active and passive charge balancing circuits are activated in electrical stimulation mode to ensure stimulation safety. In vivo experiments conducted on three anesthetized rats verified the efficacy of the two stimulation mechanisms. The proposed FF-WIOS2 is potentially a reconfigurable tool for performing untethered neuromodulation.
Modeling the vertical distribution of carbendazim in sediments

The sorption, fate, and vertical distribution of the fungicide Derosal ® with active ingredient carbendazim in sediments were investigated in indoor freshwater microcosms. Carbendazim penetration in the sediment was measured as a function of time and depth. Freundlich sorption parameters were determined by batchwise equilibration of carbendazim in a sediment suspension. Freundlich parameters were Kf = 258 μg(1‐n)Ln/kg and n = 0.78. Analysis of different layers of sediment cores showed a slow penetration of carbendazim in the first 6 cm of the sediment in 60 d. The penetration was successfully simulated with a multilayer model accounting for sorption to organic matter (using the measured isotherm), molecular diffusion, biodegradation, and bioturbation. The calibrated model was most sensitive to the parameters for molecular diffusion and sorption in the sediment. Bioturbation did not affect the carbendazim profiles because of carbendazim toxicity for bioturbators. So there was a direct feedback between carbendazim toxicity and fate. The calibrated model was validated using a dataset obtained from another freshwater microcosm.
Autologous Biologic Treatment with Fat, Bone Marrow Aspirate and Platelet Rich Plasma Is an Effective Alternative to Total Knee Arthroplasty for Patients with Moderate Knee Arthrosis

Background: Osteoarthrosis (OA) of the knee afflicts millions worldwide. Total Knee Arthroplasty (TKA) is common, but associated with substantial cost and morbidity. Prior studies of intra-articular injection of fat, bone marrow aspirate (BMA), and platelet rich plasma (PRP) have shown clinical benefit. We hypothesized that injection of autologous adipose tissue, BMA, and PRP would provide significant benefit for patients with moderate knee OA resulting in avoidance of total knee arthroplasty (TKA) in most, with discontinuance of NSAIDs and other drugs. Methods: 42 TKA candidate patients (47 knees) with moderate (Kellgren-Lawrence 2 and 3) knee OA who had failed conservative treatment had autologous adipose tissue, BMA, and PRP injection as an alternative to TKA in office using only local anesthetic. Patients had discontinuance of all nonsteroidal anti-inflammatory medicines (NSAIDs) and other analgesics, except acetaminophen, prior to treatment. Patients were evaluated with Knee injury and Osteoarthritis Outcome Score Physical Shortform (KOOS-PS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Single Assessment Numeric Evaluation (SANE) prior to treatment, and at 6 months, 1, and 2 years after treatment. Results: Follow up exceeded 80% at all time points. There were no significant adverse events. TKA was avoided in 97% at one and 86% at two years after treatment. Mean SANE, KOOS-PS, and WOMAC scores significantly improved at 6 months, 1, and 2 years post-treatment. WOMAC and SANE scores were higher at two versus one year post-treatment. Conclusions: Combined fat, BMA, and PRP injection is a safe and effective treatment for moderate knee OA, with reliable avoidance of TKA and possible continued improvement at two year follow-up.
Transcriptomic Analysis of Gill and Kidney from Asian Seabass (Lates calcarifer) Acclimated to Different Salinities Reveals Pathways Involved with Euryhalinity

Asian seabass (or commonly known as barramundi), Lates calcarifer, is a bony euryhaline teleost from the Family Latidae, inhabiting nearshore, estuarine, and marine connected freshwaters throughout the tropical Indo-West Pacific region. The species is catadromous, whereby adults spawn in salinities between 28 and 34 ppt at the mouth of estuaries, with resultant juveniles usually moving into brackish and freshwater systems to mature, before returning to the sea to spawn again as adults. The species lives in both marine and freshwater habitats and can move quickly between the two; thus, the species’ ability to tolerate changes in salinity makes it a good candidate for studying the salinity acclimation response in teleosts. In this study, the transcriptome of two major osmoregulatory organs (gills and kidneys) of young juvenile Asian seabass reared in freshwater and seawater were compared. The euryhaline nature of Asian seabass was found to be highly pliable and the moldability of the trait was further confirmed by histological analyses of gills and kidneys. Differences in major expression pathways were observed, with differentially expressed genes including those related to osmoregulation, tissue/organ morphogenesis, and cell volume regulation as central to the osmo-adaptive response. Additionally, genes coding for mucins were upregulated specifically under saline conditions, whereas several genes important for growth and development, as well as circadian entrainment were specifically enriched in fish reared in freshwater. Routing of the circadian rhythm mediated by salinity changes could be the initial step in salinity acclimation and possibly migration in euryhaline fish species such as the Asian seabass.
Potential Edaphic and Aquatic Predators of a Nonindigenous Asian Earthworm (Amynthas agrestis) in the Eastern United States

Abstract We examined the suitability of an invasive Asian earthworm, Amynthas agrestis (Asian Crazy Worm or Alabama Jumper), as a prey item for a variety of native and naturalized North American predators. We conducted no-choice feeding trials with three edaphic predators—the nonindigenous Bipalium adventitium (Wandering Broadhead Planarian), Scolopocryptops sexspinosus (Eastern Red Centipede), and Desmognathus monticola (Seal Salamander)—and two aquatic predators, Nephelopsis obscura (Ribbon Leech) and Oronectes rusticus (Rusty Crayfish). During feeding trials, Am. agrestis exhibited a variety of novel defensive strategies, including apparent distastefulness, autotomization of posterior body segments, secretion of a yellow fluid, and thrashing. Planarians, leeches, and salamanders were more likely to capture lumbricid earthworm prey than Am. agrestis prey. Rusty Crayfish showed limited differences in capture rates among the earthworm species, while Eastern Red Centipedes were equally adept at capturing all earthworm species tested. Our results suggest that endemic arthropods may provide a measure of biological resistance against incipient Am. agrestis invasions.