Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of three oral sip‐feed supplements in patients with cancer

This study set out to compare the long-term palatability of three oral sip-feed supplements. Sixty patients with various malignancies were randomized to receive one of three products—Build-Up, Fortimel and Fortisip. Participants were encouraged to take as much of the supplements each day for as long as they could manage. At the initial tasting, palatability and acceptability of the products was recorded and this was repeated throughout the trial period. Patients' reasons for discontinuing the trial were noted. Build-Up was found to be the best-tolerated product of the three. It was taken for a significantly longer time than either Fortimel or Fortisip. There was an indication that Build-Up was more acceptable at the initial tasting than Fortisip but not Fortimel. A smaller proportion of patients stopped taking Build-Up due to flavour-related reasons compared to Fortisip but there was no significant difference between Build-Up and Fortimel. In all, 54% of the patients discontinued the trial for flavour-related reasons. Thirty-five per cent found that the sip-feeds they had been allotted unpalatable at the initial tasting, while 19% stopped the trial due to ‘flavour fatigue’. Only 10% of the sample continued taking their allotted product for 90 days or more.
Updated systematic review and meta-analysis of the impact of contact force sensing on the safety and efficacy of atrial fibrillation ablation: discrepancy between observational studies and randomized control trial data

Aims Despite widespread adoption of contact force (CF) sensing technology in atrial fibrillation (AF) ablation, randomized data suggests lack of improvement in clinical outcomes. We aimed to assess the safety and efficacy of CF-guided vs. non CF-guided AF ablation. Methods and results Electronic databases were searched for randomized controlled trials (RCTs) and controlled observational studies (OS) comparing outcomes of AF ablation performed with vs. without CF guidance. The primary efficacy endpoint was freedom from AF at follow-up. The primary safety endpoint was major peri-procedural complications. Secondary endpoints included procedural, fluoroscopy, and ablation duration. Subgroup analyses were performed by AF type and study design. Nine RCTs (n = 903) and 26 OS (n = 8919) were included. Overall, CF guidance was associated with improved freedom from AF [relative risk (RR) 1.10; 95% confidence interval (CI) 1.02-1.18], and reduced total procedure duration [mean difference (MD) 15.33 min; 95% CI 6.98-23.68], ablation duration (MD 3.07 min; 95% CI 0.29-5.84), and fluoroscopy duration (MD 5.72 min; 95% CI 2.51-8.92). When restricted to RCTs however, CF guidance neither improved freedom from AF (RR 1.03; 95% CI 0.95-1.11), independent of AF type, nor did it reduce procedural, fluoroscopy, or ablation duration. Contact force guidance did not reduce the incidence of major peri-procedural complications (RR 0.89; 95% CI 0.64-1.24). Conclusion Meta-analysis of randomized data demonstrated that CF guidance does not improve the safety or efficacy of AF ablation, despite initial observational data showing dramatic improvement. Rigorous evaluation in randomized trials is needed before widespread adoption of new technologies.
Fatty Acid Composition and Thermotropic Behavior of Glycolipids and Other Membrane Lipids of Ulva lactuca (Chlorophyta) Inhabiting Different Climatic Zones

Increasing global temperatures are expected to increase the risk of extinction of various species due to acceleration in the pace of shifting climate zones. Nevertheless, there is no information on the physicochemical properties of membrane lipids that enable the adaptation of the algae to different climatic zones. The present work aimed to compare fatty acid composition and thermal transitions of membrane lipids from green macroalgae Ulva lactuca harvested in the Sea of Japan and the Adriatic Sea in summer. U. lactuca inhabiting the Adriatic Sea had bleached parts of thalli which were completely devoid of chloroplast glycolipids. The adaptation to a warmer climatic zone was also accompanied by a significant decrease in the ratio between unsaturated and saturated fatty acids (UFA/SFA) of membrane lipids, especially in bleached thalli. Hence, bleaching of algae is probably associated with the significant decrease of the UFA/SFA ratio in glycolipids. The decreasing ratio of n-3/n-6 polyunsaturated fatty acids (PUFAs) was observed in extra-plastidial lipids and only in the major glycolipid, non-lamellar monogalactosyldiacylglycerol. The opposite thermotropic behavior of non-lamellar and lamellar glycolipids can contribute to maintenance of the highly dynamic structure of thylakoid membranes of algae in response to the increasing temperatures of climatic zones.
FPGA-based DOCSIS upstream demodulation

In recent years, the state-of-the-art in field programmable gate array (FPGA) technology has been advancing rapidly. Consequently, the use of FPGAs is being considered in many applications which have traditionally relied upon application-specific integrated circuits (ASICs). FPGA-based designs have a number of advantages over ASIC-based designs, including lower up-front engineering design costs, shorter timeto-market, and the ability to reconfigure devices in the field. However, ASICs have a major advantage in terms of computational resources. As a result, expensive high performance ASIC algorithms must be redesigned to fit the limited resources available in an FPGA. Concurrently, coaxial cable television and internet networks have been undergoing significant upgrades that have largely been driven by a sharp increase in the use of interactive applications. This has intensified demand for the so-called upstream channels, which allow customers to transmit data into the network. The format and protocol of the upstream channels are defined by a set of standards, known as DOCSIS 3.0, which govern the flow of data through the network. Critical to DOCSIS 3.0 compliance is the upstream demodulator, which is responsible for the physical layer reception from all customers. Although upstream demodulators have typically been implemented as ASICs, the design of an FPGAbased upstream demodulator is an intriguing possibility, as FPGA-based demodulators could potentially be upgraded in the field to support future DOCSIS standards. Furthermore, the lower non-recurring engineering costs associated with FPGA-based designs could provide an opportunity for smaller companies to compete in this market. The upstream demodulator must contain complicated synchronization circuitry to detect, measure, and correct for channel distortions. Unfortunately, many of the synchronization algorithms described in the open literature are not suitable for either upstream cable channels or FPGA implementation. In this thesis, computationally inexpensive and robust synchronization algorithms are explored. In particular, algo-
Transcriptome and Hormone Comparison of Three Cytoplasmic Male Sterile Systems in Brassica napus

The interaction between plant mitochondria and the nucleus markedly influences stress responses and morphological features, including growth and development. An important example of this interaction is cytoplasmic male sterility (CMS), which results in plants producing non-functional pollen. In current research work, we compared the phenotypic differences in floral buds of different Brassica napus CMS (Polima, Ogura, Nsa) lines with their corresponding maintainer lines. By comparing anther developmental stages between CMS and maintainer lines, we identified that in the Nsa CMS line abnormality occurred at the tetrad stage of pollen development. Phytohormone assays demonstrated that IAA content decreased in sterile lines as compared to maintainer lines, while the total hormone content was increased two-fold in the S2 stage compared with the S1 stage. ABA content was higher in the S1 stage and exhibited a two-fold decreasing trend in S2 stage. Sterile lines however, had increased ABA content at both stages compared with the corresponding maintainer lines. Through transcriptome sequencing, we compared differentially expressed unigenes in sterile and maintainer lines at both (S1 and S2) developmental stages. We also explored the co-expressed genes of the three sterile lines in the two stages and classified these genes by gene function. By analyzing transcriptome data and validating by RT-PCR, it was shown that some transcription factors (TFs) and hormone-related genes were weakly or not expressed in the sterile lines. This research work provides preliminary identification of the pollen abortion stage in Nsa CMS line. Our focus on genes specifically expressed in sterile lines may be useful to understand the regulation of CMS.
Growth signaling and longevity in mouse models

Reduction of insulin/insulin-like growth factor 1 (IGF1) signaling (IIS) extends the lifespan of various species. So far, several longevity mouse models have been developed containing mutations related to growth signaling deficiency by targeting growth hormone (GH), IGF1, IGF1 receptor, insulin receptor, and insulin receptor substrate. In addition, p70 ribosomal protein S6 kinase 1 (S6K1) knockout leads to lifespan extension. S6K1 encodes an important kinase in the regulation of cell growth. S6K1 is regulated by mechanistic target of rapamycin (mTOR) complex 1. The v-myc myelocytomatosis viral oncogene homolog (MYC)-deficient mice also exhibits a longevity phenotype. The gene expression profiles of these mice models have been measured to identify their longevity mechanisms. Here, we summarize our knowledge of long-lived mouse models related to growth and discuss phenotypic characteristics, including organ-specific gene expression patterns.
Inferring sleep stage from local field potentials recorded in the subthalamic nucleus of Parkinson's patients

Parkinson's disease (PD) is highly comorbid with sleep dysfunction. In contrast to motor symptoms, few therapeutic interventions exist to address sleep symptoms in PD. Subthalamic nucleus (STN) deep brain stimulation (DBS) treats advanced PD motor symptoms and may improve sleep architecture. As a proof of concept toward demonstrating that STN‐DBS could be used to identify sleep stages commensurate with clinician‐scored polysomnography (PSG), we developed a novel artificial neural network (ANN) that could trigger targeted stimulation in response to inferred sleep state from STN local field potentials (LFPs) recorded from implanted DBS electrodes. STN LFP recordings were collected from nine PD patients via a percutaneous cable attached to the DBS lead, during a full night's sleep (6–8 hr) with concurrent polysomnography (PSG). We trained a feedforward neural network to prospectively identify sleep stage with PSG‐level accuracy from 30‐s epochs of LFP recordings. Our model's sleep‐stage predictions match clinician‐identified sleep stage with a mean accuracy of 91% on held‐out epochs. Furthermore, leave‐one‐group‐out analysis also demonstrates 91% mean classification accuracy for novel subjects. These results, which classify sleep stage across a typical heterogenous sample of PD patients, may indicate spectral biomarkers for automatically scoring sleep stage in PD patients with implanted DBS devices. Further development of this model may also focus on adapting stimulation during specific sleep stages to treat targeted sleep deficits.
Synergistic Action of Sodium Selenite with some Antidepressants and Diazepam in Mice

Background: The antidepressant and anxiolytic effects of selenium (Se) have been proven in many studies. This work was aimed at confirming these activities of its inorganic form—sodium selenite—and examining the possible synergy of action with antidepressants and diazepam. Methods: The antidepressant- and anxiolytic-like activity of Se was assessed using forced swim tests (FSTs) and elevated plus-maze test (EPMs). Spontaneous locomotor activity was measured using photoresistor actimeters. The experiments were conducted on male Albino Swiss mice. Results: Sodium selenite (0.5 mg/kg) reduced the immobility time in the FSTs and extended time spent in the open arms of EPMs without affecting locomotor activity The combined administration of Se at an ineffective dose (0.25 mg/kg) together with imipramine (15 mg/kg), fluoxetine (5 mg/kg), tianeptine (10 mg/kg), but not with reboxetine (2.5 mg/kg), resulted in a reduction of immobility time in FSTs, and with a threshold dose of diazepam (0.25 mg/kg) led to the prolongation of time spent in the open arms of the EPM. Moreover, the antidepressant-like effect of Se (0.5 mg/kg) was significantly reduced by pretreatment with p-chlorophenylalanine (100 mg/kg). Conclusions: The results may indicate the participation of serotonergic transmission to antidepressant action of Se and GABA-ergic transmission to its anxiolytic effects.
Modulation of Protein Synthesis by eIF2α Phosphorylation Protects Cell from Heat Stress-Mediated Apoptosis

Global warming poses a considerable threat to human health, necessitating a proper understanding of mechanisms underlying cell death in the pathogenesis of heat-related diseases. Although mechanisms governing cytoplasmic response to heat are well understood, processes regulating cellular response to disruption of proteostasis in the endoplasmic reticulum (ER) due to heat stress remain unclear. The current study reveals that hyperthermic conditions may lead to a disturbance of ER homeostasis, also known as ER stress. Subsequent activation of the unfolded protein response (UPR) resulted in concomitant induction of cell death. Among the three UPR signaling pathways, the eIF2α phosphorylation pathway, and not the IRE1α/ATF6α pathways, is likely the main contributor to cell death under heat stress. Considering the role of eIF2α in translational control, we investigated the protective effect of translation rate on heat stress-mediated cell death. When protein synthesis was attenuated using cycloheximide or homoharringtonine, cell death due to heat stress was significantly reduced. In summation, we propose that transient modulation of protein synthesis by eIF2α phosphorylation has a pivotal role in protecting cells from heat stress-induced apoptosis. Therefore, pharmacological agents that promote eIF2α phosphorylation or reduce ER stress may contribute to the development of promising therapeutic approaches against heat-related diseases.
Review of rodent hypertensive glaucoma models

Glaucoma is a neurodegenerative disease characterized by the progressive loss of retinal ganglion cells (RGCs). Elevated intraocular pressure (IOP) is a primary risk factor for the development and progression of glaucoma. Rodent models of glaucoma have greatly improved our understanding of the pathophysiology of glaucoma and served as a useful tool to investigate neuroprotective agents. An ideal glaucoma animal model should be easy to induce, reproducible, biologically plausible and predictable. Of the available animal models of glaucoma, rodents are commonly studied because they have a relatively short life span and can be genetically altered. A successful hypertensive glaucoma model should induce structural glaucomatous changes: including loss of retinal nerve fibres, retinal ganglion cells and optic‐disc cupping along with IOP elevation. The level and duration of IOP elevation should be titratable depending on the targeted glaucomatous damage. This review summarizes the outcomes of induced rodent hypertensive glaucoma models including intracameral injection of microbeads, laser photocoagulation, episcleral vein cauterization, injection of hypertonic saline and hyaluronic acid. We aim to provide a detailed overview of each of the models with a focus on parameters that defines a successful glaucoma model. The induced IOP elevation and duration of elevation varied among the different models and strain of rodent; nonetheless, they all achieved a sustainable raised IOP with corresponding RGC loss. The limitations of each model are discussed.
Discovering anomalies in access modifiers in Java with a formal specification

We use attribute grammars to formally specify the semantics of the access modifiers in the Java language. This formal specification uncovers several situations that are irregular or counter-intuitive. These situations are confusing to the programmers and may create weaknesses in Java program. From this exercise, we learn that a formal specification is indispensable in designing a new language.
Close-Range Camera Calibration

: For highest accuracies it is necessary in close range photogrammetry to account for the variation of lens distortion within the photographic Jield. A theory to accomplish this is developed along with a practical method for calibrat- ing radial and decenfering distortion of close-range cameras. This method, the analytical plumb line method, is applied in a n experimental investigation lead- ing to confirmation of the validity of the theoretical development accounting for variation of distortion with object distance.
The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model

Recent clinical studies have demonstrated the protective effect of xanthine oxidase (XO) inhibitors against chronic kidney diseases, although the underlying molecular mechanisms remain unclear. However, to date, neither clinical nor basic research has been carried out to elucidate the efficacy of XO inhibitor administration for IgA nephropathy. We thus investigated whether febuxostat, an XO inhibitor, exerts a protective effect against the development of IgA nephropathy, using gddY mice as an IgA nephropathy rodent model. Eight-week-old gddY mice were provided drinking water with (15 μg/mL) or without febuxostat for nine weeks and then subjected to experimentation. Elevated serum creatinine and degrees of glomerular sclerosis and fibrosis, judged by microscopic observations, were significantly milder in the febuxostat-treated than in the untreated gddY mice, while body weights and serum IgA concentrations did not differ between the two groups. In addition, elevated mRNA levels of inflammatory cytokines such as TNFα, MCP-1, IL-1β, and IL-6, collagen isoforms and chemokines in the gddY mouse kidneys were clearly normalized by the administration of febuxostat. These data suggest a protective effect of XO inhibitors against the development of IgA nephropathy, possibly via suppression of inflammation and its resultant fibrotic changes, without affecting the serum IgA concentration.
Temporal enhancer profiling of parallel lineages identifies AHR and GLIS1 as regulators of mesenchymal multipotency

Abstract Temporal data on gene expression and context-specific open chromatin states can improve identification of key transcription factors (TFs) and the gene regulatory networks (GRNs) controlling cellular differentiation. However, their integration remains challenging. Here, we delineate a general approach for data-driven and unbiased identification of key TFs and dynamic GRNs, called EPIC-DREM. We generated time-series transcriptomic and epigenomic profiles during differentiation of mouse multipotent bone marrow stromal cell line (ST2) toward adipocytes and osteoblasts. Using our novel approach we constructed time-resolved GRNs for both lineages and identifed the shared TFs involved in both differentiation processes. To take an alternative approach to prioritize the identified shared regulators, we mapped dynamic super-enhancers in both lineages and associated them to target genes with correlated expression profiles. The combination of the two approaches identified aryl hydrocarbon receptor (AHR) and Glis family zinc finger 1 (GLIS1) as mesenchymal key TFs controlled by dynamic cell type-specific super-enhancers that become repressed in both lineages. AHR and GLIS1 control differentiation-induced genes and their overexpression can inhibit the lineage commitment of the multipotent bone marrow-derived ST2 cells.
HISTOLOGICAL ASPECTS OF THE STOMACH (PROVENTRICULUS AND GIZZARD) OF THE RED-CAPPED CARDINAL (Paroaria gularis gularis, LINNAEUS, 1766)

Un estudio morfologico (histologico) del estomago (proventriculo y molleja) del cardenal rojo (Paroaria gularis gularis) fue efectuado bajo microscopio de luz. Anatomicamente, el estomago del cardenal rojo esta constituido por dos camaras distintas: la region craneal, glandular o el proventriculo (proventriculus, pars glandularis), la cual se esta conectada cranialmente con el esofago y caudalmente, esta el ventriculo (ventriculus, pars muscularis) tambien conocida como porcion muscular. Ambas, la tunica mucosa del proventriculo y del ventriculo presentan pliegues alineados de epitelio simple prismatico. Una cuticula densa esta colocada encima de la tunica mucosa del ventriculo. En la lamina propia de ambas regiones, se encuentran glandulas tubulares simples. La submucosa del proventriculo esta ocupado por glandulas proventriculares profundas. Debido a la ausencia de una mucosa muscular, la submucosa del ventriculo no puede ser distinguido de la lamina propia. La tunica mucosa del proventriculo, consiste de un lecho interior longitudinal, de un lecho intermedio circular y de un lecho externo longitudinal discontinuo de musculo liso. En el ventriculo, consiste de un lecho longitudinal interno y de un lecho circular externo. En ambas camaras, la serosa esta constituida por tejido conectivo revestido por mesotelio, conteniendo vasos sanguineos, elementos nerviosos del plexo seroso y tejido adiposo
Interpretation of English Reflexives by Child and Adult L2 Learners

This book casts new light on the debate of adult L2 learners' access to Universal Grammar (UG) by comparing the performance of adult L2 learners with that of child L2 learners. The study in this book compares Arabic- and Chinese-speaking child and adult L2 learners' acquisition of English reflexives, particularly concentrating on the differences between child and adult L2 learners in terms of their a) acquisition of the local binding of English reflexives, b) obedience of UG constraints on reflexives and c) knowledge of the syntactic differences between reflexives and pronouns. The outline of the book goes as follows: chapter one is a general introduction to the study. Chapter two discusses the linguistic assumptions and empirical evidence of Usage-Based-Approaches and Generative Approaches with regards to language acquisition, in general, and the interpretation of reflexives, in particular. Adopting Generative Grammar as a theoretical background for this study, age effects on access to UG in first and second language acquisition are discussed in chapter three. Chapter four presents different views on access to UG in second language acquisition and reviews previous studies on the acquisition of reflexives by L2 learners. Chapter five discusses the methodology of this study in terms of participants' selection, materials used, procedures followed and data analysed. Chapter six presents the results of the study, and chapter seven discusses the results of the study with regards to previous studies and theories. The study shows that the grammar of adult L2 learners is constrained by UG and they can have full access to UG in advanced stages of L2 acquisition. The findings of this study will be of interest to L2 researchers in generative grammar, in general, and in second language acquisition, in particular.
Gene mutations in a Han Chinese Alzheimer's disease cohort

Alzheimer's disease (AD) is the most common form of dementia characterized by memory loss at disease onset. The gene mutations in the amyloid precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2) are the frequent causes of AD. However, the clinical and genetic features of AD overlap with other neurodegenerative diseases. The present study aimed to identify the clinical and genetic characteristics in a Han Chinese AD cohort.