Miracle-dz/UniFAR-FTUs huggingface dataset:
QUANTITATIVE STRUCTURE–ACTIVITY RELATIONSHIP (QSAR) OF PHENYLALANINE SERIES AS TRYPTOPHAN HYDROXYLASE-1 (TPH1) INHIBITOR

B3LYP level of theory with 6-311G(d,p), and 6311G++(2d,2p) basis sets were used to calculate a set of molecular descriptors of phenylalanine series as tryptophan hydroxylase-1(TPH) inhibitors. These series of phenylalanine are structurally different. Quantitative Structures–Activity Relationship (QSAR) of 32 inhibitors of tryptophan hydroxylase-1(TPH1) were established using some calculated quantum mechanical descriptors such as Low Unoccupied Molecular Orbital energy (ELUMO)) and High Occupied Molecular Orbital energy (EHOMO)), the differences between HOMO and LUMO energies ∆E, electronegativity (x), hardness (η), softness (s), electrophilicity index (ω), chemical potential (μ), electrofugality ∆Ee nucleofugaliy ∆En, molar volume (mv), polarizability (α), and hyper-polarizability (β). Quantitative StructureActivity Relationship (QSAR) was used to predict the activities/properties of title compounds as a function of its molecular substituents. This prediction will clarify the essential quantitative structure-activity relationship of them and give some advantageous sources for the design of new compounds. Keywords— Hyper-conjugative, TPH1 inhibitors, polarizability, molar volume, hyper-polarizability.
Single nucleotide polymorphism of growth hormone gene in Assam hill goats and their association with growth

The present investigation was carried out to study the occurrence of polymorphism in growth hormone (GH) gene in Assam Hill Goat and to associate polymorphic gene, if any, with body weights of the goats at 0 day, 3, 6, 9 and 12 months of age. A total of 256 blood samples were collected from male goats maintained at different field units and at the Goat Research Station, Assam Agricultural University, Burnihat under the “ICAR-All India Coordinated Research Project on Goat Improvement”. The body weights of the same animals were recorded at 0 day, 3, 6, 9 and 12 months of age. PCR-RFLP analysis with Hae III restriction enzyme revealed two genotypes, viz. AA (25.39%) and AB (74.61%) with the gene frequency 0.63 (A) and 0.37 (B). The genotype frequency for AA and AB were found to be 0.40 and 0.60 respectively. Chi-square test revealed that the population was not in Hardy-Weinberg Equilibrium. The mean body weight at 0 day, 3, 6, 9 and 12 months of age for AA and AB genotypes were recorded to be 1.18 ± 0.03 and 1.16 ± 0.02, 5.37 ± 0.11 and 4.78 ± 0.06, 7.50 ± 0.12 and 7.14 ± 0.08, 9.69 ± 0.14 and 10.03 ± 0.11 and 12.74 ± 0.17 and 13.32 ± 0.11 kg respectively. However, statistical analysis did not show any significant difference (p>0.05) in body weights among the different
Aerobic fitness and body fat of elite Greek soccer referees

The aim of this study was to examine the aerobic fitness and the percentage of body fat (% BF) of elite Greek referees of the Super League. In the research project, the participants were sixteen men (mean age 36.4±4.9 years) and one female referee who were enrolled in the Referees technical committee (ΚΕΔ-in Greek) of the Hellenic Soccer Federation (EPO). The results showed that the average of the maximum uptake of oxygen (VO2max) for men was 51.7±6.4 ml/kg/min and for the female referee it was 44.1 ml/kg/min. Moreover, the results showed that older referees had higher aerobic fitness levels, implying that they can easily cope with game demands. The conclusion of this research is that Greek referees of the Super League have a satisfying level of aerobic fitness compared to foreign referees. Additionally, the average of men’s body fat percentage was 15.3±2.8%, while for the woman it was 16.3%. Although the % BF for men referees is acceptable, further improvements will enhance their performance. Finally, for the female referee, her % BF was of good standards.
Optimization of regeneration and transformation system in finger millet (Eleucine coracana L.)

A proficient in vitro regeneration protocol and transformation system is a requisite for genetic improvement of finger millet. Finger millet (Eleucine coracana L.) GN-4 was used for optimization of regeneration protocol. Using seed as a explants, highest frequency of callus induction was observed on MS supplemented with 2,4-D (1.0 mg.L-1), Proline (500 mg.L-1) and Casein enzyme hydrolysate (300 mg.L-1). Among the different combinations used for shoot initiation, MS with kinetin (1.50 mg.L-1) and BAP (0.50 mg.L-1) produced maximum number of shoots (11.00) having highest shoot length (11.2 cm). Within six days, maximum numbers of roots (12.3) were obtained on half strength MS basal media fortified with NAA (1 mg.L-1). In hardening process, maximum survival (44.51%) of plantlets with minimum days for new sprouting (4.4 days) was reported in vermicompost: sand: cocopeat (1:1:1 v.v-1) mixture. Agrobacterium tumefaciens mediated genetic transformation system was optimized and putative transgenic plants were confirmed by PCR. When the effect of the age of the callus and co-cultivation duration were evaluated, forty five days old co-cultivated callus for five days yielded 1.33% frequency of transformation.
Survey of RDF Keyword Query Techniques

With the development of the Semantic Web and information extraction technologies, more and more available RDF data has emerged on the Web. It has become one of the research hot spots in semantic Web technology. In this paper, in terms of RDF data organization and storage, as well as query expression, query processing. The analysis and comparison of RDF keyword query approaches are presented deeply and future research challenges are put forward.
Detection of Multi-Class Website URLs Using Machine Learning Algorithms

Online phishing is one of the Internet's most widespread crime schemes. A common counter measure includes testing URLs against blacklists of established phishing websites, which are typically collected on the basis of manual verification and are inefficient. As the Internet scale expands, automatic URL detection is increasingly necessary to provide timely security for end-users. In this paper, we propose an efficient and versatile malicious URL detection system with a rich collection of features representing the diverse characteristics of phishing websites and their hosting platforms, including features that are difficult to forge. Using the Random Forests algorithm, our program benefits from both high detection capacity and low error levels. Based on our experience, this is the first research to carry out these large-scale websites / URL scanning and classification experiments, taking advantage of the distributed viewing points for the feature set. The results of the experiment show that our program can be used by the blacklist provider to create automated blacklists.
EXPANDING MOLECULAR TOOLS FOR THE METABOLIC ENGINEERING OF RALSTONIA EUTROPHA H16

Ralstonia eutropha H16 (also known as Cupriavidus necator H16) is a non-pathogenic chemolithoautotrophic soil bacterium. It has increasingly gained biotechnological interest for its use as a microbial cell factory for the production of several valuable bio-based chemicals. However the absence of a large repertoire of molecular tools to engineer this organism remains a critical limiting factor to exploiting its full biotechnological potential. Also, adopting established molecular tools applicable to the more notable microbial hosts such as E. coli and Saccharomyces cerevesiae is severely hampered by chassis-incompatibility and functional variability of essential biological parts. The work detailed in this thesis focuses on the development of key molecular tools crucial to improving the biosynthesis of malonyl-CoA - a precursor metabolite required for the biosynthesis of fatty acids and potentially several valuable bio-products in Ralstonia eutropha H16. All molecular tools developed were based on the broad host range (BHR) plasmid vector backbone of pBBR1MCS1 – a R. eutropha H16-compatible vector. Firstly, to facilitate heterologous pathway optimization, a combination of pre-existing and novel methods of genetic modifications were applied to engineer a collection of 42 promoters. Promoter strengths were characterized using a fluorescence-based assay and benchmarked to the dose-dependent activity of an L-arabinose-inducible PBAD promoter. Next, to detect intracellular accumulation of malonyl-CoA, transcriptional factor-based malonyl-CoA-sensing genetic circuits were developed via careful selection from the promoter collection. Thirdly, BHR L-arabinose-inducible λ-Red plasmid vectors were developed for mediating λ-Red-based genome editing. These were first tested in E. coli BW25113 to confirm their functionality and then subsequently tested in R. eutropha H16. Overall, the collection of engineered promoters yielded a 137-fold range of promoter activity and the malonyl-CoA biosensors responded to changing malonyl-CoA concentrations. The BHR λ-Red plasmids showed high recombination efficiency in E. coli BW25113. The molecular tools developed from this work will further facilitate rapid control and regulation of gene expression in R. eutropha, particularly for malonyl-CoA engineering.
A fine‐scale phylogenetic assessment of digenean trematodes in central Alberta reveals we have yet to uncover their total diversity

Abstract Despite over 100 years of digenean trematode parasite species descriptions, from a wide diversity of vertebrate and invertebrate host species, our ability to recognize the diversity of trematode species within a single lake remains an incredible challenge. The most challenging aspect is the identification of species from larval stages derived from intermediate hosts, due to the disjointed data of adult worm morphological descriptions, from which species are named, and links to corresponding molecular identifiers in depauperate databases. Cryptic species also play a significant role in the challenge of linking trematode larvae to adults, species identifications, and estimating diversity. Herein, we utilize a large, longitudinal dataset of snail first‐intermediate host infection data from lakes in Alberta, Canada, to infer trematode larval diversity using molecular phylogenetics and snail host associations. From our assessments, we uncover a diversity of 79 larval trematode species among just five snail host species. Only 14 species were identified to a previously described species, while the other 65 species are either cryptic or otherwise unrepresented by mitochondrial genes in GenBank. This study currently represents the largest and most diverse singular molecular survey of trematode larval fauna composed of over one thousand mitochondrial sequences. Surprisingly, rarefaction analyses indicate we have yet to capture the complete diversity of trematodes from our sampling area.
Conceptual Test Rig for Real-Time Analysis of Operation of Thermostatic System of High-Voltage

This article describes conceptual test rig for real-time analysis of operation of thermostatic system of high-voltage components of electric vehicle traction drive in X-in-the loop tests. Integration architecture of test rigs located in European countries is discussed aiming at analysis of processes occurring in various systems of electric vehicle, such as anti-lock system, motor–wheel, suspension, thermostatic system of high-voltage components. Test modes are also described, which are required for studies of various components and systems of electric vehicles under various conditions. A set of various scenarios was required to demonstrate flexibility and speed of response of X-in-the-loop environment, as well as analysis of operation of specific systems in overall vehicle. The article describes a method to control actuators of thermostatic system implemented on test rig as well as devices for simulation of thermal and hydraulic properties of cooled objects (motor-wheels and invertors) in real time.
Authentication Process in Smart Card Using Sha-256

Smart cards are related to the issues of security. The applications of smart card are manipulated in hardware, software and telecommunications which appears to be a big issue. In this paper we introduce a new design which is a secured 2 level processing in authentication which uses the number of the pin as 1st authenticated level by the use of SHA-256. OTP is brought as a 2nd authenticated processing level. The project is to generate an OTP using the sha-256 hashing algorithm. As the program initiates, ‘local host: 8080/view’ is typed in the web browser to bring up the front end of the application. Client and server nodes are created in the client node, the column for the username, credentials, messages and the trust values created while on server node, name and user credentials are created.
Combined Networks with Multi-level Attention for Distantly-Supervised Relation Extraction

Distantly-supervised relation extraction is expected to extract relational facts from very large corpora. However, it is inevitably accompanied by the problem of mislabeling, which affects the performance of relation extraction. To obtain richer information from sentences and make full use of the information of entity pairs, we propose the combined networks containing piecewise convolutional neural networks (PCNN) and bidirectional gated recurrent units (BiGRU) with multi-level attention. In this model, PCNN and BiGRU are utilized to obtain local features and sequence information. Then the multi-level attention is proposed to extract the most correlated information, which can affect the assignment of sentence attention weight. And it reduces the influence of wrong labeled instances indirectly. The experimental results show that our method can enhance the representation power of the network and prove the effectiveness of our model compared with several baseline methods.
Abundance and spatial distribution of blue swimming crab (Portunus pelagicus) larvae during east monsoon in the East Lampung waters, Indonesia

Kembaren DD, Zairion, Kamal MM, Wardiatno Y. 2018. Abundance and spatial distribution of blue swimming crab (Portunus pelagicus) larvae during east monsoon in the East Lampung waters, Indonesia. Biodiversitas 19: 1326-1333. The blue swimming crab/BSC, Portunus pelagicus, is an economically important species in fishery industry and continuously being exploited, particularly in the East Lampung waters. BSC research in Indonesia during the last decade was only restricted to the adult phase, while research on their larval dynamics in nature has not been done yet. This study aimed to assess the abundance and the distribution of BSC larvae, and to describe their correlation to its environmental conditions. This study was conducted in June 2017 (during east monsoon) in the East Lampung waters. Sampling was done in surface water during the daylight hours on nine sites with three replicates on each site. Plankton abundance and oceanographic profile were also recorded from the same sampling site. The result from this study showed that the water quality from the environment was suitable for the development of BSC larvae. The abundance of the early-stage larvae (Z1-Z3) was relatively higher than the late-stage larvae (Z4 and M). The larval stages of BSC were dispersed and completed their development in the mid-shore and offshore waters. There was a tendency that the early-stage was more abundant in the northern part, while the late-stage was more abundant in the southern part of the study area. The highest larval abundance was found in the mid-shore, particularly in site number five, which was influenced by the water mass density and current direction during the east monsoon. Moreover, oxygen concentration and salinity of the water environment influenced the early-stage larvae abundance more than the late-stages abundance.
Convolutional neural network model based on text similarity for customer service

Customer service is a good way for companies to communicate with customers, high-quality customer service can improve customer satisfaction and dependence on the enterprise. Text matching is a core problem in natural language understanding, and it can be applied to a large number of natural language processing tasks, such as information retrieval, question answering systems, repetition questions, dialogue systems, machine translation. These natural language processing tasks can be approximately abstracted into text matching problems. This paper combines text matching and convolutional neural networks to build an intelligent customer service model, and finally achieves ideal results in F1 value, recall rate and accuracy rate.
What is the Value of Film Copyrights? – An Analysis of Basic Methods of Valuation

The functioning of the film production sector strongly depends on the use of copyrights and related rights. Problems regarding their clearing could badly harm the functioning of companies and in some cases lead to serious financial problems. The development of a proper method for calculating the value of copyrights and related rights is an important task in the current climate of the new economy. This type of valuation is not a typical task for film producers or copyright owners. There is a problem with using common methods. The largest set of operating costs for companies like television companies and VoD platforms are usually content costs related to copyrights and neighborhood rights. Broadcasters, TV stations, cable operators and Pay TV providers pay producers content fees. Additionally, Copyright Management Organizations (CMOs) collect fees for copyright-protected content that is broadcast and rebroadcast. There are many court disputes related to copyright fees. The main reason for disputes is the lack of a common methodology for calculating compensation for copyright owners and the potential for misunderstanding the real value of copyrights. The objective of this analysis is to show basic methods for financial valuation of copyrights related to film. The author has carefully analyzed and described common methods applicable for the financial valuation of copyrights and described their advantages and disadvantages.
Corn-based or high linoleic acid flushing increases productivity of Morada Nova and Brazilian Somalis ewes

SUMMARY The objective of this study was to compare the corn-based (FLU), high linoleic acid flushings(LAF), and a control treatment (un supplemented, CON); two genetic groups:Morada Nova (MN) and Brazilian Somalis (BS), on the productive and reproductive performance of ewes and their lambs. A total of 156 non-pregnant ewes were supplemented three weeks before and after the breeding season. Supplementation with either FLU or LAF increased ewe body condition score (BCS) at the beginning of the breeding season and at lambing compared to CON. The BS ewes had greater body weights at the supplementation end, and BCS both at the supplementation start, and at lambing compared to MN. Similarly, ewes with three lambs per birth had greater BCS at the beginning of supplementation. They also had greater weights at the beginning of the breeding season and at lambing. Both FLU and LAF increased total lamb weight from 56 to 105 days of age compared to CON.The BS ewes had decreased prolificity and produced lower total weight of lambs at lambing, but greater 84 and 105 days after birth compared to MN. Total lambweight at birth was greater for ewes that lambed three, followed by two and then one lamb per birth. In conclusion, the high linoleic acid and high corn supplementation increase body condition score of ewes form breeding season to lambing and enhance lamb performance after 56 days of age. Although Morada Nova ewes increased prolificacy, their lambs were lighter after they reached 84 days of age.
Unrecognised (species) diversity in New Guinean passerine birds

ABSTRACT Species represent an important unit for the study of diversity, but may not always be delimited consistently across regions and clades. Many of these taxonomic inconsistencies are due to the variable views of taxonomists. In recent years, however, new methodologies have attempted to circumvent this problem by assigning more objective criteria for the delimitation of species, drawing on a wide range of data such as DNA, morphology, vocalisation and ecology. Here, we apply a genetic screening approach in which we sequence the mitochondrial gene ND2 for all recognised subspecies of 16 species in eight genera (a mix of lowland and montane species) from the geologically complex tropical island of New Guinea. We show that populations within some species are genetically highly divergent despite little morphological differentiation, but we also find an example in which populations from five morphologically distinct species are genetically very similar. Overall, our data show higher levels of genetic differentiation than expected, but also highlight the difficulty of predicting which groups contain unrecognised diversity. These results are interesting in their own right, but also have implications for further analyses that focus on increasing our understanding of how diversity builds up over time.
Halophilic bacteria induce resistance and promote growth of stem canker-infected tomato plants grown under greenhouse conditions.

The present study was carried out to investigate potential of halophilic bacteria to induce plant resistance as well as to promote growth of tomato. The results indicated that halophilic bacteria were able to induce PR-proteins and total proteins in treating tomato. Among four halophilic bacteria tested, strain M3-23 of Virgibacillus marismortui was strongly able to induce PR-proteins, especially chitinase and glucanase produced by tomato plants infected by Botrytis cinerea . The tomato growth was also promoted by the halophilic bacteria. Furthermore, in vitro antifungal activities proved the most efficiency of strain J9 of Bacillus subtilis as well as the strain J31of Terribacillus halophilus on mycelial biomass reduction, hyphae destruction and inhibition of spore germination of the fungal pathogen. This study demonstrates the efficacy of the halophilic bacteria to improve tomato defense and protection against stem canker.
Assessing the population density of the spotted paca, Cuniculus paca, (Rodentia: Cuniculidae) on an Atlantic Forest island, southeastern Brazil

The spotted paca,Cuniculuspaca (Linnaeus, 1766), is a Neotropical, opportunistic, frugivorous caviomorph rodent, that inhabits primarily broadleaf forests. We aimed to provide the first estimates of density of C.paca for the Ilha Grande, an island located in the Atlantic Rain Forest biome of Brazil. Density and population size were estimated using the total number of individuals observed along each trail through the program DISTANCE 7. Our estimates of density and population size reinforces the importance of the Ilha Grande as an important reservoir of the species. Therefore, the results presented herein can be a starting point to support future action plans for the species, making predictions regarding the ecosystem and management and conservation of the spotted paca. Furthermore, the results can be used as a surrogate for other regions in which the species occurs.