Miracle-dz/UniFAR-FTUs huggingface dataset:
Bias Corrected Maximum Likelihood Estimator Under the Generalized Linear Model for a Binary Variable

Under the generalized linear models for a binary variable, an approximate bias of the maximum likelihood estimator of the coefficient, that is a special case of linear parameter in Cordeiro and McCullagh (1991), is derived without a calculation of the third-order derivative of the log likelihood function. Using the obtained approximate bias of the maximum likelihood estimator, a bias-corrected maximum likelihood estimator is defined. Through a simulation study, we show that the bias-corrected maximum likelihood estimator and its variance estimator have a better performance than the maximum likelihood estimator and its variance estimator.
Author ' s personal copy Integrated pricing of roads and electricity enabled by wireless power transfer

This paper explores integrated pricing of electricity and roads enabled by wireless power transfer technology. We envision that high-power, high-efficiency wireless power transfer technologies are mature in the near future, which electrify roads to be charging infrastructures. The prices of electricity at electrified roads will affect electric vehicles’ route choices while the energy requirement of those vehicles will in return affect the operations of the power network and thus the prices of electricity. To determine the optimal prices of electricity and roads to maximize social welfare, firstand second-best pricing models are proposed under different authoritarian regimes. More specifically, assuming that a government agency manages both transportation and power systems, we develop the first-best pricing model, based on which a marginal-cost pricing scheme is derived. The second-best pricing model is proposed if the agency participates in a competitive wholesale power market while being able to impose tolls on electrified roads. The toll design is formulated as a mathematical program with complementarity constraints, and is solved by a manifold suboptimization algorithm. Numerical examples are presented to offer insights on integrated pricing of roads and electricity and demonstrate its effectiveness on improving social welfare. 2013 Elsevier Ltd. All rights reserved.
The animacy advantage for free-recall performance is not attributable to greater mental arousal

ABSTRACT People often demonstrate better memory for animate concepts (e.g., lion and sailor) than for inanimate concepts (e.g., hammer and mountain). Researchers have attributed this effect to an adaptive memory mechanism that favours information relevant for survival, including information about living things. In the present experiment, we examined the hypothesis that people demonstrate better free-recall performance for animate than inanimate words because animate words tend to be associated with greater mental arousal than inanimate words, a factor that was not controlled for in previous experiments on this topic. To this end, we matched animate and inanimate word lists on mental arousal (and several other factors), and compared participants’ free-recall performance for the two word types. We were able to replicate past findings that participants’ free-recall of animate words exceeds their free-recall of inanimate words, but we found no support for the possibility that the effect stems from differences in mental arousal between animate and inanimate concepts, as this effect maintained even when the word lists were matched on mental arousal. The present results therefore indicate that mental arousal cannot explain the effects of animacy on free-recall performance.
Detection and isolation of black hole attack in wireless sensor network using hybrid techniques(Received packet and time delay)

Wireless Sensor Network is a network consisting thousands of small nodes which provides conviction communication for sensor(data), have ability to activate device that have only control conditions like switches and others and it is monitoring the physical and environmental condition of the networks. Basically wireless sensor network is part of Ad-hoc network. It is very laborious to recharge or change the batteries, like very difficult to monitor the application underwater because communication or signal made through only sound wave. So, without the proper countermeasures, under sensor networking is a mission unsound. In this paper we detect and handling the black hole attack by using Received packet and time delay concept in the wireless sensor network. The study of various Black hole detection schemes for sensor networks presents a classification for various approaches followed. Simulation of time synchronization technique is conceded over two different scenario with same source node and destination node.
Characteristics of Cefotaxime-Resistant Escherichia coli from Wild Birds in The Netherlands

ABSTRACT Cloacal swabs from carcasses of Dutch wild birds obtained in 2010 and 2011 were selectively cultured on media with cefotaxime to screen for the presence of extended-spectrum β-lactamase (ESBL)/AmpC-producing Escherichia coli. Subsequently, all cefotaxime-resistant E. coli isolates were tested by broth microdilution and microarray. The presence of ESBL/AmpC and coexisting plasmid-mediated quinolone resistance (PMQR) genes was confirmed by PCR and sequencing. To determine the size of plasmids and the location of ESBL and PMQR genes, S1 pulsed-field gel electrophoresis (PFGE) was performed on transformants, followed by Southern blot hybridization. The study included 414 cloacal swabs originating from 55 different bird species. Cefotaxime-resistant E. coli isolates were identified in 65 birds (15.7%) from 21 different species. In all, 65 cefotaxime-resistant E. coli ESBL/AmpC genes were detected, mainly comprising variants of bla CTX-M and bla CMY-2. Furthermore, PMQR genes [aac(6′)-lb-cr, qnrB1, and qnrS1] coincided in seven cefotaxime-resistant E. coli isolates. Overall, replicon typing of the ESBL/AmpC-carrying plasmids demonstrated the predominant presence of IncI1 (n = 31) and variants of IncF (n = 18). Our results indicate a wide dissemination of ESBL and AmpC genes in wild birds from The Netherlands, especially among aquatic-associated species (waterfowl, gulls, and waders). The identified genes and plasmids reflect the genes found predominantly in livestock animals as well as in humans.
STACKED PATCH MIMO ANTENNA ARRAY FOR C-BAND APPLICATIONS

Microstrip antenna arrays are one of the popular antenna configurations for nowadays wireless communication system. The paper proposes a compact novel design of multiple elements electromagnetically coupled stacked antenna array which operates in Cband. The antenna resonates at 6 GHz and shows bandwidth of 521 MHz with 5.84dBi gain. The proposed antenna shows the ECC to be 0.03 which indicated quite perfect behaviour for the MIMO antenna array system. The proposed MIMO system offers good capacity for data transfer. The simulated results of the antenna in terms of return loss, diversity gain and radiation pattern, capacity of the antenna system is presented in this paper. Simulations are carried out with CST MWS’14 and capacity plots are made using MATLAB R’11b. KeywordsStacked, Bandwidth, ECC, MIMO, Array, C-band, Return loss, Diversity gain, CST MWS’14, MATLAB R’11b.
Circulating Tumor Cell Analysis in Patients with Progressive Castration-Resistant Prostate Cancer

Purpose: To better direct targeted therapies to the patients with tumors that express the target, there is an urgent need for blood-based assays that provide expression information on a consistent basis in real time with minimal patient discomfort. We aimed to use immunomagnetic-capture technology to isolate and analyze circulating tumor cells (CTC) from small volumes of peripheral blood of patients with advanced prostate cancer. Experimental Design: Blood was collected from 63 patients with metastatic prostate cancer. CTCs were isolated by the Cell Search system, which uses antibodies to epithelial cell adhesion marker and immunomagnetic capture. CTCs were defined as nucleated cells positive for cytokeratins and negative for CD45. Captured cells were analyzed by immunofluorescence, Papanicolau staining, and fluorescence in situ hybridization. Results: Most patients (65%) had 5 or more CTCs per 7.5 mL blood sample. Cell counts were consistent between laboratories (c = 0.99) and did not change significantly over 72 or 96 h of storage before processing (c = 0.99). Their identity as prostate cancer cells was confirmed by conventional cytologic analysis. Molecular profiling, including analysis of epidermal growth factor receptor (EGFR) expression, chromosome ploidy, and androgen receptor (AR) gene amplification, was possible for all prostate cancer patients with ≥5 CTCs. Conclusions: The analysis of cancer-related alterations at the DNA and protein level from CTCs is feasible in a hospital-based clinical laboratory. The alterations observed in EGFR and AR suggest that the methodology may have a role in clinical decision making.
Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system

Hypocretin has been identified as a regulator of metabolic and endocrine systems. Several brain regions involved in the central regulation of autonomic and endocrine processes or attention are targets of extensive hypocretin projections. The most dense arborization of hypocretin axons in the brainstem was detected in the locus coeruleus (LC). Multiple labeling immunocytochemistry revealed a massive synaptic innervation of catecholaminergic LC cells by hypocretin axon terminals in rats and monkeys. In both species, all tyrosine hydroxylase‐immunopositive cells in the LC examined by electron microscopy were found to receive asymmetrical (excitatory) synaptic contacts from multiple axons containing hypocretin. In parallel electrophysiological studies with slices of rat brain, all LC cells showed excitatory responses to the hypocretin‐2 peptide. Hypocretin‐2 uniformly increased the frequency of action potentials in these cells, even in the presence of tetrodotoxin, indicating that receptors responding to hypocretin were expressed in LC neurons. Two mechanisms for the increased firing rate appeared to be a reduction in the slow component of the afterhyperpolarization (AHP) and a modest depolarization. Catecholamine systems in other parts of the brain, including those found in the medulla, zona incerta, substantia nigra or olfactory bulb, received significantly less hypocretin input. Comparative analysis of lateral hypothalamic input to the LC revealed that hypocretin‐containing axon terminals were substantially more abundant than those containing melanin‐concentrating hormone. The present results provide evidence for direct action of hypothalamic hypocretin cells on the LC noradrenergic system in rats and monkeys. Our observations suggest a signaling pathway via which signals acting on the lateral hypothalamus may influence the activity of the LC and thereby a variety of CNSfunctions related to noradrenergic innervation, including vigilance, attention, learning, and memory. Thus, the hypocretin innervation of the LC may serve to focus cognitive processes to compliment hypocretin‐mediated activation of autonomic centers already described. J. Comp. Neurol. 415:145–159, 1999. © 1999 Wiley‐Liss, Inc.
Development of a Medical-text Parsing Algorithm Based on Character Adjacent Probability Distribution for Japanese Radiology Reports

Summary Objectives: The objectives of this study were to investigate the transitional probability distribution of medical term boundaries between characters and to develop a parsing algorithm specifically for medical texts. Methods: Medical terms in Japanese computed tomography (CT) reports were identified using the ChaSen morphological analysis system. MeSH-based medical terms (51,385 entries), obtained from the metathesaurus in the Unified Medical Language System (UMLS, 2005AA), were added as a medical dictionary for ChaSen. A radiographer corrected the set of results containing 300 parsed CT reports. In addition, two radiologists checked the medical term parsing of 200 CT sentences. Results: We obtained modified inter-annotator agreement scores for the text corrected by the radiologists. We retrieved the transitional probability as the conditional probability of a uni-gram, bi-gram, and tri-gram. The highest transitional probability P(Ci | Ci - 2*Ci - 1) was 1.00. For an example of anatomical location, the term “pulmonary hilum” was parsed as a tri-gram. Conclusions: Retrieval of transitional probability will improve the accuracy of parsing compound medical terms.
Coa 2 Is an Assembly Factor for Yeast Cytochrome c Oxidase Biogenesis That Facilitates the Maturation of Cox 1

The assembly of cytochrome c oxidase (CcO) in yeast mitochondria is dependent on a new assembly factor designated Coa2. Coa2 was identified from its ability to suppress the respiratory deficiency of coa1 and shy1 cells. Coa1 and Shy1 function at an early step in maturation of the Cox1 subunit of CcO. Coa2 functions downstream of the Mss51-Coa1 step in Cox1 maturation and likely concurrent with the Shy1-related heme a3 insertion into Cox1. Coa2 interacts with Shy1. Cells lacking Coa2 show a rapid degradation of newly synthesized Cox1. Rapid Cox1 proteolysis also occurs in shy1 cells, suggesting that in the absence of Coa2 or Shy1, Cox1 forms an unstable conformer. Overexpression of Cox10 or Cox5a and Cox6 or attenuation of the proteolytic activity of the m-AAA protease partially restores respiration in coa2 cells. The matrix-localized Coa2 protein may aid in stabilizing an early Cox1 intermediate containing the nuclear subunits Cox5a and Cox6.
Channel function reconstitution and re‐animation: a single‐channel strategy in the postcrystal age

The most essential properties of ion channels for their physiologically relevant functions are ion‐selective permeation and gating. Among the channel species, the potassium channel is primordial and the most ubiquitous in the biological world, and knowledge of this channel underlies the understanding of features of other ion channels. The strategy applied to studying channels changed dramatically after the crystal structure of the potassium channel was resolved. Given the abundant structural information available, we exploited the bacterial KcsA potassium channel as a simple model channel. In the postcrystal age, there are two effective frameworks with which to decipher the functional codes present in the channel structure, namely reconstitution and re‐animation. Complex channel proteins are decomposed into essential functional components, and well‐examined parts are rebuilt for integrating channel function in the membrane (reconstitution). Permeation and gating are dynamic operations, and one imagines the active channel by breathing life into the ‘frozen’ crystal (re‐animation). Capturing the motion of channels at the single‐molecule level is necessary to characterize the behaviour of functioning channels. Advanced techniques, including diffracted X‐ray tracking, lipid bilayer methods and high‐speed atomic force microscopy, have been used. Here, I present dynamic pictures of the KcsA potassium channel from the submolecular conformational changes to the supramolecular collective behaviour of channels in the membrane. These results form an integrated picture of the active channel and offer insights into the processes underlying the physiological function of the channel in the cell membrane.
Ultrastructural observations of the tegument of Postorchigenes gymnesicus (Digenea: Lecithodendriidae)

Abstract The tegument of Postorchigenes gymnesicus has been studied by scanning and transmission electron microscopy. The general body tegument is spinous and contains mitochondria, biconcave disc-shaped vesicles bounded by an unitary membrane and displaying a protein content, and scarce spherical bodies. The tegument covering specialized body regions is aspinous. Few vesicles were evident in the tegument covering the suckers and oesophagus, being more abundant in the metraterm and cirrus where the tegument is thicker. Laurer's canal has a thick tegument with sparse vesicles, mostly arranged close to the apical membrane. A direct association was evident between the basal lamina underlying the spines and the muscular subtegumental fibres, suggesting a motile character for the spine.
Identification of New Antigenic Peptide Presented by HLA-Cw7 and Encoded by Several MAGE Genes Using Dendritic Cells Transduced with Lentiviruses 1

Antigens encoded by MAGE genes are of particular interest for cancer immunotherapy because they are tumor specific and shared by tumors of different histological types. Several clinical trials are in progress with MAGE peptides, proteins, recombinant poxviruses, and dendritic cells (DC) pulsed with peptides or proteins. The use of gene-modified DC would offer the major advantage of a long-lasting expression of the transgene and a large array of antigenic peptides that fit into the different HLA molecules of the patient. In this study, we tested the ability of gene-modified DC to prime rare Ag-specific T cells, and we identified a new antigenic peptide of clinical interest. CD8+ T lymphocytes from an individual without cancer were stimulated with monocyte-derived DC, which were infected with a second-generation lentiviral vector encoding MAGE-3. A CTL clone was isolated that recognized peptide EGDCAPEEK presented by HLA-Cw7 molecules, which are expressed by >40% of Caucasians. Interestingly, this new tumor-specific antigenic peptide corresponds to position 212–220 of MAGE-2, -3, -6, and -12. HLA-Cw7 tumor cell lines expressing one of these MAGE genes were lysed by the CTL, indicating that the peptide is efficiently processed in tumor cells and can therefore be used as target for antitumoral vaccination. The risk of tumor escape due to appearance of Ag-loss variants should be reduced by the fact that the peptide is encoded by several MAGE genes.
CRM as a Support for Knowledge Management and Customer Relationship

This paper aims to analyze the role of Customer Relationship Management (CRM) as a support for Knowledge Management (KM) and the Customer Relationship Strategy Definition in an Information Technology (IT) Company. This work is based on theories of KM, IT, and Relationship Marketing. Our survey uses a descriptive approach, in which data is gathered by means of content analysis of semi-structured interviews. The study results have shown us that the company implements an effective system for CRM, in which the system users transform data into information and knowledge in order to support decision-making and strategy definition.
Impact of variation in structure of condensed tannins from sainfoin (Onobrychis viciifolia) on in vitro ruminal methane production and fermentation characteristics.

Our study investigated the effects of condensed tannins (CT) on rumen in vitro methane (CH4 ) production and fermentation characteristics by incubating lucerne in buffered rumen fluid in combination with different CT extracts at 0 (control), 40, 80 and 120 g CT/kg of substrate DM. Condensed tannins were extracted from four sainfoin accessions: Rees 'A', CPI63763, Cotswold Common and CPI63767. Gas production (GP) was measured using a fully automated GP apparatus with CH4 measured at distinct time points. Condensed tannins differed substantially in terms of polymer size and varied from 13 (Rees 'A') to 73 (CPI63767) mean degree of polymerization, but had relatively similar characteristics in terms of CT content, procyanidin: prodelphinidin (PC: PD) and cis:trans ratios. Compared to control, addition of CT from CPI63767 and CPI63763 at 80 and 120 g CT/kg of substrate DM reduced CH4 by 43% and 65%, and by 23% and 57%, respectively, after 24-h incubation. Similarly, CT from Rees 'A' and Cotswold Common reduced CH4 by 26% and 46%, and by 28% and 46% respectively. Addition of increasing level of CT linearly reduced the maximum rates of GP and CH4 production, and the estimated in vitro organic matter digestibility. There was a negative linear and quadratic (p < 0.01) relation between CT concentration and total volatile fatty acid (VFA) production. Inclusion of 80 and 120 g CT/kg of substrate DM reduced (p < 0.001) branched-chain VFA production and acetate: propionate ratio and was lowest for CPI63767. A decrease in proteolytic activity as indirectly shown by a change in VFA composition favouring a shift towards propionate and reduction in branched-chain VFA production varied with type of CT and was highest for CPI63767. In conclusion, these results suggest that tannin polymer size is an important factor affecting in vitro CH4 production which may be linked to the CT interaction with dietary substrate or microbial cells.
250Mbps-5Gbps wide-range CDR with digital vernier phase shifting and dual mode control in 0.13μm CMOS

A multi-port serial link with a wide-range CDR using digital Vernier phase shifting and dual mode control is presented. The proposed Vernier phase shifter generates fine-resolution phase steps and provides unlimited phase rotating. With the dual mode control, the proposed CDR extends the operating range from 250Mbps to 5Gbps. The proposed CDR provides 13.34ps phase steps at 5Gbps and achieves a BER of less than 10−12 for the range of 250Mbps to 5Gbps. Fabricated in a 0.13-μm CMOS process, the proposed CDR dissipates 19.2mW at 5Gbps from a 1.2-V supply.
Matching based Highlight Removal

This paper presents a three-step framework to remove the highlight exists on objects in certain conditions. Unlike traditional HDR (High Dynamic Range) technology requires multiple registrated image sequence; our method needs only two arbitrary images. SURF (Speeded Up Robust Features) matching algorithm is first applied to find corresponding point pairs between images; homography is then found by perspective transformation theory; minimum gray selection is used at last to eliminated the highlight and fuse related regions. Experimental results are given to demonstrate the performance of our method.
Emotion challenge: building a new photoreal facial performance pipeline for games

In recent years the expected standard for facial animation and character performance in AAA video games has dramatically increased. The use of photogrammetric capture techniques for actor-likeness acquisition, coupled with video-based facial capture and solving methods, has improved quality across the industry. However, due to variability across project pipelines, increased per-project scope for performance capture, and a reliance on external vendors, it is often challenging to maintain visual consistency from project to project, and even from character to character within a single project. Given these factors, we identified the need for a unified, robust, and scalable pipeline for actor likeness acquisition, character art, performance capture, and character animation.