Miracle-dz/UniFAR-FTUs huggingface dataset:
Allogeneic Hematopoietic Stem Cell Transplantation for Myelofibrosis.

Abstract 2283 Poster Board II-260 Background: Reduced intensity allogeneic transplantation was developed to harness graft versus leukemia immune effect to treat older patients and patients with comorbidities who are not eligible for conventional myeloablative transplant. Aim: To prospectively study the safety and efficacy of reduced intensity HCT in patients with myelofibrosis. Methods: Patients with intermediate or high risk MF were eligible if they had adequate organ function and at least 9/10 matched related or unrelated donor. Fifteen patients were conditioned with Fludarabine 40mg/m2 × 4 (days -5, -4, -3 -2) and Busulfan 130mg/m2 × 2 (day -3,-2). Thymoglobulin 2.5 mg/kg x 3 (day -3,-2 and 1) was additionally given to patients receiving unrelated donor graft. Because of high incidence of relapse, Busulfan dose was increased to a target AUC of 4000 μmol/L or a fixed dose of 100mg/m2 × 4 (days -5, -4, -3 -2) in 11 patients. Tacrolimus and mini Methotrexate were used as graft versus host disease prophylaxis. All patients received standard supportive care. Results: Between 6/2005 and 07/2009, 26 consecutive patients with myelofibrosis were treated. There were 13 males and 13 females with a median age of 58 (range 27-74). Seventeen patients had primary MF, 3 post PV MF and 6 Post ET MF. Based on Lille criteria, 14 patients had intermediate risk disease and 12 had high risk disease. Ten patients had splenectomy prior to transplant; remaining 16 patients had enlarged spleen at the time of transplant. Fourteen patients had mutated Jak 2. Median peripheral blood CD 34 count was 57/μl(range 1-3770/μl). Karyotype was abnormal in 11 patients and diploid in 15. Donors were matched siblings for 10 patients, matched unrelated for 12, and one antigen or allele mismatched unrelated for 4 patients. Stem cell source was marrow in 3 and peripheral blood in 23. All patients engrafted with a median time to neutrophil engraftment of 13 days (0-27) days) and a median time to platelet engraftment of 24 (0-105) days. Jak 2 positive patients achieved molecular remission post transplant with negative JaK 2. With a median follow up of 21 (1-43) months, 2 year overall and event free survival are 71% (SE 10%) and 46% (SE 11%), respectively. Cumulative incidence of non relapse mortality was 14% (SE 7%). Cumulative incidence of relapse was 39% (SE10%). Eight patients relapsed; 3 in blast phase and 5 in chronic phase. Four of these 8 are currently disease free after a second transplant. Including these 4 patients, 18 out of 26 patients are currently disease free. These include 10 of 11 patients treated with higher dose of busulfan compared with 8 of 15 patients treated with lower busulfan dose. Conclusion: RISCT induces molecular remission with very low non relapse mortality in older patients with myelofibrosis, but the relapse rate is high. Increasing the intensity of conditioning regimen may reduce the relapse risk and needs to be studied further. Disclosures: No relevant conflicts of interest to declare.
Learning the dynamics of technical trading strategies

We use an adversarial expert based online learning algorithm to learn the optimal parameters required to maximise wealth trading zero-cost portfolio strategies. The learning algorithm is used to determine the dynamics of a large population of technical trading strategies that can survive historical back-testing as well as form an overall aggregated portfolio trading strategy from the set of underlying trading strategies implemented on daily and intraday Johannesburg Stock Exchange data. The resulting population time-series are investigated using unsupervised learning for dimensionality reduction and visualisation. A key contribution is that the overall aggregated trading strategies are tested for statistical arbitrage using a novel hypothesis test, on both daily sampled and intraday time-scales. The (low frequency) daily sampled strategies fail the arbitrage tests after costs, while the (high frequency) intraday sampled strategies are not falsified as statistical arbitrages after costs. The estimates of trading strategy success, cost of trading and slippage are considered along with an offline benchmark portfolio algorithm for performance comparison. In addition, the algorithms generalisation error is analysed by recovering a probability of back-test overfitting estimate using a nonparametric procedure. The work aims to explore and better understand the interplay between different technical trading strategies from a data-informed perspective.
Sports Betting, Horse Racing and Nanobiosensors – An Ethical Evaluation

ABSTRACT Horse racing has begun to enter an economic decline in many countries, notably represented by a decline in revenues in betting volumes. A number of reasons may be attributed to this: the success of other sports; new online betting practices; and concerns over animal welfare. In response to this, horse racing institutions have begun to modify its practices, employing technologies such as GPS sensors and Wi-Fi active racetracks, with the aim of engaging a new generation of spectators, including betting spectators, to the sport. We consider a new biotechnological potential for the sport to develop through the use of nano/biosensors in horse racing. The biological data collected by these sensors in real time could be used to offer a number of potential benefits to the sport, such as new forms of bets, support for animal welfare and increased levels of immersive spectator experience. Despite these potential benefits, the use of nano/biosensors can also expose the sport to a number of disbenefits such as increased opportunities for corruption, technological determinism, and issues concerning unethical use of the data collected. We present a critical ethical evaluation of this potential development and argue that stakeholder consensus is required before the technology is implemented, and that an appropriate regulatory framework is established to support its (potential) implementation.
The New Paradigm of Prophetic Education in the Disruption Era of Industrial Revolution 4.0

The role of educators has shifted from initial function as a main source of learning to function as a facilitator. The sophistication of technology and the automation of work by relying on robots and big data is perceived to be able to answer all issues and to understand the soul of a human being needed by people who have strong psychological intelligence and character. Transformation in education is inevitable. At this stage, the new education model is proven to be better than the old education model in the context of knowledge transfer to students. Therefore, the incumbent institution will accelerate and transform the new model in education management. Administrative services must change and be changed. The increasing number of students without the support of digital technology will be increasingly ineffective. In the era of disruption, students simply enter the self-corner (Eco) to serve administrative aspects independently, then request validation from staff and leaders. This will reduce the bureaucracy which has been a barrier in almost all institutions, including educational institutions. Then the educational revolution through shifting paradigms needs to be done through (1) strengthening prophetic values, (2) changing educator mindset and strengthening character values, (3) humanizing technology in learning, (4) inclusion of information technology in study rooms, and (5) self-services and assignments paperless tasks. The results of this study indicate that uncertainty, complexity, and anxiety are the main characteristics of the era of disruption and the era of the industrial revolution. This study perceived the disruption era not as a threat, but as an opportunity for the world of Education to innovate and develop.
Mapping of the FKSI specific kidney disease measure onto three generic preference-based measures to generate utility values

Chronic kidney disease (CKD) is a progressive and irreversible loss of renal function, due to different causes (diabetic nephropathy, hypertension, glomerulonephritis, hereditary renal failure, pharmacological poisoning, etc.) that lead to the kidneys losing their ability to eliminate waste, concentrate urine and preserve electrolytes in the blood, progressing towards the total loss of kidney function. At advanced stages, usual treatments are kidney transplantation, hemodialysis and peritoneal dialysis, all of which have a notable impact on daily life and the quality of life of patients.
Gendered mobility and violence in the São Paulo metro, Brazil

With about 12 million inhabitants, São Paulo, Brazil, is the largest city in South America. As in many other major southern hemisphere cities, this extreme concentration of people imposes a number of mobility and security challenges. The objective of this article was to investigate the space-time patterns of mobility and violent victimisation in São Paulo’s metro stations from a gender perspective. The methodology combines use of a Geographical Information System (GIS), statistical analysis through negative binomial regression modelling and hypothesis testing. Results indicate that mobility and the level of victimisation are gender dependent. Women are at higher risk of victimisation than men in São Paulo’s central metro station, while men run higher risk of violence at end stations – both notably during late night periods. The presence of employees reduces the risk of violence, except during the mornings. The article suggests that crime prevention initiatives need to be gender informed and sensitive to the particular spatial and temporal features of rapid transit environments.
A study of the cell biology of motility in Eimeria tenella sporozoites.

A study on the cell biology of motility in Eimeria tenella sporozoites Eimeria tenella is an obligate intracellular parasite within the phylum Apicomplexa. It is the causative agent of coccidiosis in domesticated chickens and under modem farming conditions can have a considerable economic impact. Motility is employed by the sporozoite to effect release from the sporocyst and enable invasion of appropriate host cells and occurs at an average speed of 16.7 ± 6 pm s'\ Frame by frame video analysis of gliding motility shows it to be an erratic non­ substrate specific process and this observation was confirmed by studies of bead translocation across the cell surface occurring at an average speed of 16.9 ± 7.6 pms'^ Incubation with cytochalasin D, 2,3-butanedione monoxime and colchicine, known inhibitors of the motility associated proteins actin, myosin and tubulin respectively, indicated that it is an actomyosin complex which generates the force to power sporozoite motility. Western blotting analysis confirmed the presence of actin with an apparent molecular weight of 43kDa and an unconventional myosin with an apparent molecular weight of 93kDa. Antibodies against the actin binding proteins spectrin, vinculin, filamin, a-actinin, cofilin and tropomyosin failed to recognise any polypeptides in whole cell extracts. Immunofiuoresence studies showed actin was found predominantly in the anterior third of the sporozoite. Myosin appeared to have a more widespread distribution, with a strong signal found at the margins of the cell. Genomic DNA samples were prepared and two degenerate primers against highly conserved regions of the myosin head were used in a polymerase chain reaction (PCR) to probe for the presence of myosin genes. These PCR products were inserted into suitable plasmids followed by amplification in bacteria. Selection of appropriate bacterial colonies and subsequent DNA sequence analysis identified a clone with significant homology to a Homo sapiens myosin II gene previously described.
Quality of Care and Patient Safety

This issue of Proceedings in Obstetrics and Gynecology (POG) is devoted to exploring issues related to the quality of care provided to patients and to patient safety. In 1999 the Institute of Medicine (IOM) published “To Err is Human: Building a Safer Health System”. This identified the number of deaths that occur in hospitals related to medical errors and served as a “call to action” to improve safety for patients. The IOM published a follow-up report in 2001 entitled “Crossing the Quality Chasm” A New Health System for the 21 Century”; this report emphasized the provision of “timely, effective, efficient, equitable, and patient-centered care”. According to DE Detmer, the premises of safe care include (a) healthcare should be viewed from a systems perspective with the patient at the center, (b) analysis of care should be continuous, with the aim being to improve outcomes, and (c) decisions should be based on evidence. In its most recent Committee Opinion that specifically addresses “Patient Safety in Obstetrics and Gynecology”, the American College of Obstetricians and Gynecologists (ACOG) focuses attention on fostering a culture that prioritizes patient safety, promoting safe medication and surgical practices, promoting effective communication between members of the healthcare team, addressing systems issues, and working with patients to improve safety.
Review of Lithium Battery Equalization Control Methods

The high performance of power battery pack is used in the field of electric vehicles widely. With the continuous improvement of the cruising range, the energy imbalance of the power battery has become a limiting factor. This paper analyses and introduces the power battery equalization circuit. According to different circuit topologies, they are divided into two categories: Energy dissipative and non-energy dissipative. We Focused on the analysis of the working principle, advantages and disadvantages of the non-capacity dissipative equalization structure. Finally, this work summarizes the application and development direction of the power battery equalization control in recent years.
Design and Characterization of a Silicon W-Band Woodpile Photonic Crystal Waveguide

In this letter, we present the design, fabrication, and characterization of a 3-D photonic crystal (PhC) waveguide based on an optimized woodpile structure operating in the millimeter-wave band. By carefully adjusting the size and shape of the air defect, a silicon electromagnetic bandgap (EBG) woodpile waveguide can be created: this dielectric waveguide supports a well-confined TE10-like mode. Numerical results for this structure have been obtained using the finite element method (FEM) simulation software Ansys HFSS and present very good agreement with the measured ones.
“They come here because it’s a place of refuge”: Residential Care Facilities with Cultural Affiliations

With the increase in Canada’s seniors population (age 65 and over), there is a need to understand the residential requirements of this population. Almost 90 percent of seniors in Ontario reside in urban areas (Hodge 2008) and the majority live in the Greater Toronto Area. Of particular concern is the decrease in availability of informal care for aging and weakening individuals due to changes in economy and family relations. These changes are likely to result in a large influx of seniors into residential care facilities (RCFs) because not everyone is able to stay at home or is eligible to live in a long term care (LTC) facility. Seniors’ reasons for relocating as well as an analysis of their experiences after the move are required as the need for RCFs increases. Cultural and/or religious groups have become important providers of RCFs in Canada by offering necessary services for an aging population. The goal of this thesis is to analyse the importance of culture and the built environment within a push-pull framework associated with the decision to move to an RCF through a case study. The guiding question of the research is: Why do seniors choose facilities with cultural affiliations? In 2013, interviews were conducted with 15 residents, who were currently residing in a Ukrainian RCF called Ivan Franko. The results show that seniors move because of certain limitations (e.g., health, difficulty doing housework, family events, etc.). When an older person decides that they want or need to move, they will move to a facility that provides a physical and social environment while reinforcing cultural values (i.e., built environment), assuming a place is available. Acknowledging the limitations of a qualitative case study approach, the findings are important to consider as the multicultural population of the GTA and other large Canadian cities continue to age. The growing demand for places in RCFs reflects social, cultural and religious needs of a diverse older population. A challenge will exist for cultural and religious not-for-profit voluntary organizations, the for-profit sector, and governments at all levels to seek new ways to develop facilities in the future.
Comparative In Vitro Study on the Accuracy of Digital versus Conventional Full Arch Implant Impressions

Aim & Hypothesis: An accurate implant impression is integral for generating an accurate master cast, which is necessary for the fabrication of an accurately-fitting prosthesis. The aim of this study was to compare two different intra-oral scanners (CEREC Omnicam and 3M True Definition) with each other and with conventional implant impressions in terms of accuracy for a completely edentulous mandibular cast. The hypothesis was that the splinted open tray impressions would be more accurate than digital impressions in cases of complete edentulism. Materials & Methods: A PMMA model representing an edentulous mandible was fabricated using five internal connection implant analogs (Straumann Bone Level RC, Basel, Switzerland). The 3 median implants were parallel to each other, the far left implant had 10 degrees distal angulation and the far right had 15 degrees distal angulation. An impression was taken using polyether to produce a stone master cast to serve as control. Digital impressions (n=10) were taken with two intraoral optical scanners (CEREC Omnicam and 3M True Definition) after connecting polymer scan bodies to the master cast. A splinted open-tray technique was used for the conventional polyether impressions of the master cast (n=10). Master cast and conventional impression casts were digitized with an extra-oral high resolution scanner (Activity 880 scanner; Smart Optics, Bochum, Germany) to obtain digital files. Standard tessellation language (STL) datasets from the three groups of digital and conventional impressions were superimposed with the STL dataset from the master cast to assess the 3-D deviations. Deviations were recorded as root mean square error. To compare the master cast with conventional and digital impressions at the implant-level, Welch’s F test was used together with Games-Howell post-hoc test.
GENDER BIAS AS REFLECTED ON UPIN & IPIN THE SERIES

This paper describes gender bias as reflected in Upin & Ipin the series. This study employed qualitative research methods in which the objects were observed repeatedly to construct indicators that reflected gender bias. Then it was followed by analyzing them within sociological and feminist perspectives. It showed that there was an imbalance in gender position within several episodes of Upin & Ipin. As one of the media forms that later on becoming an instructional media, it should posit its position neutrally in the term of gender issues. The content of the gender bias in Upin & Ipin reflected within characters and settings. It reflected as the characters articulate their dialogues and behave in their daily life. There was a tendency to determine the ownership of boys and girls based on colors and things. In this case, pink regarded as to belong to girls. Also, there was a tendency to describe that girls and boys behave differently. For example, girls should be gentle and neat, and boys should be strong and brave. In the term of setting, gender bias reflected in the domination of areas that boys dominate outdoor public space while girls are in the domestic sector (households). Abstrak: Artikel ini memaparkan hasil penelitian terhadap serial animasi Upin & Ipin yang memperlihatkan bias gender dalam beberapa episodenya. Sebagai salah satu bentuk media yang kemudian menjadi media pembelajaran seharusnya bisa berposisi netral dalam hal gender. Penelitian ini menggunakan metode penelitian kualitatif. Objek material diamati secara berulang untuk memperoleh indikator yang menunjukkan bias gender yang kemudian dianalisis dalam kerangka sosiologi dan perspektif feminisme. Hasil penelitian menunjukkan muatan bias gender dalam Upin & Ipin terdapat dalam tokoh dan penokohan serta pembentukan latar. Dalam tokoh dan penokohan serial animasi ini, melalui dialog dan lakuannya, terdapat kecenderungan “kepemilikkan” warna dan benda tertentu. Dalam hal ini, warna merah muda dianggap sebagai warna “milik” perempuan. Di samping itu, terdapat pula kecenderungan sifat dan perilaku perempuan dan laki-laki. Perempuan harus memiliki sifat lembut dan rapi sementara laki-laki harus keras dan berani. Dalam latar cerita, muatan bias gender muncul sebagai bentuk wilayah dominasi perempuan dan laki-laki. Perempuan dibatasi dalam wilayah domestik rumah tangga sementara laki-laki berada di wilayah luar (publik).
The Relationship between Teachers' Psychological Capital and Caring School Leadership and Enabling School Structure

Teacher attrition is a continuing issue facing schools in the United States. A lack of administrative support and working conditions are often cited as causes of job dissatisfaction and lack of career commitment, which in turn lead to burnout and intent to leave. Psychological capital (PsyCap) has been extensively studied and found to have a positive correlation to the outcomes of job satisfaction and commitment and a negative correlation to stress and burnout. Some leadership models have been found to be an antecedent to PsyCap. The purpose of this study was to examine the relationship of teachers’ PsyCap with the predictor variables of caring school leadership and enabling school structure. This study used a correlational design utilizing the self-report measures of the Psychological Capital Questionnaire (PCQ-12), Caring School Leadership Questionnaire (CSLQ) and Enabling School Structure (ESS) survey. There were 109 K-12 state-certified teachers of a cyber charter school in Pennsylvania who participated in the study. Results of a multiple regression analysis suggested there was a significant predictive relationship of the combination of caring school leadership and enabling school structure on teachers’ PsyCap. Additionally, bivariate linear regression analyses also demonstrated a significant predictive relationship of each predictive variable on the criterion variable of PsyCap. Future research recommended include replication studies in different educational settings, such as in district schools and religious/faith-based schools, as well as qualitative studies on the specific phenomena teachers identify with caring school leadership.