Miracle-dz/UniFAR-FTUs huggingface dataset:
A safety and efficacy analysis of direct-antiviral therapy in patients with chronic hepatitis C after renal transplantation

Background To explore the safety and efficacy of direct antiviral therapy in patients with hepatitis C virus (HCV) infection after renal transplantation. Methods We retrospectively reviewed the medical information of 15 cases of HCV+ patients treated with direct antiviral therapy after renal transplantation in our center. The effectiveness of direct antiviral therapy was evaluated by analyzing the HCV-RNA levels of patients at 1, 4, 12, 24, and 48 weeks before and after antiviral therapy. In addition, parameters including the rejection rate, the blood concentration of anti-rejection drugs, liver function level [alanine aminotransferase (ALT), aspartate transaminase (AST)], estimated glomerular filtration rate (eGFR) and serum creatinine (CREA) levels were used to assess its safety. Results A total of 15 patients were enrolled in the study. All patients turned HCV-RNA negative after 12 weeks of direct-antiviral therapy; the serological test of all patients demonstrated an 100% response rate in rapid virological response (RVR) (15/15), 12-week sustained virological response (SVR12), and 24-week sustained virological response (SVR24). In addition, compared to pre-treatment, the liver function within 12, 24, and 48 weeks after treatment was significantly improved. Moreover, eGFR, CREA, and anti-rejection drug concentration remained stable while acute rejection reaction and other obvious side effects were not observed throughout the treatment period. Conclusions The direct antiviral therapy was well-tolerated and effective for patients with chronic hepatitis C after renal transplantation.
COMPARISON OF TURKEY WITH DEVELOPED COUNTRIES IN TERMS OF HEALTH MANAGEMENT PROFESSION

Objective: This study was conducted to compare the current state of health management profession in Turkey in accordance with the state in developed countries in the direction of the opinions of the experts. Materials and Methods: In this study carried out by using qualitative research method, phenomenology design was utilized. In the survey conducted by face-to-face interview technique, participants' graduation from health management departments was determined as a criterion. A total of 12 health management graduates were interviewed. Participants consist of 4 professors, 2 associate professors, 4 assistant professors and 2 heads of civil society organizations. The obtained data were collected by using face-to-face interview technique and voice recorder. In the analysis of the data, "thematic analysis" which is one of the qualitative data analysis methods and "Nvivo" program which is one of the qualitative data analysis programs were used. Findings: When looking at the result part of the research, the answers given by the experts in the question "What can you say when you compare our country with the developed countries in terms of health management profession? " were analyzed. When the answers given by the experts to this question are analyzed, four themes were found: "occupational status", "management style", "health management policies" and "health management education". Conclusion: In terms of "Health Management Education" which is one of these four theens, it is seen that the opinions of experts comparing the healthcare profession in our country and the situation in developed countries are collected in two different groups. In the first group, they argued that the health care profession in our country is not even different from Europe and America, even better. In the second group opinion, it is emphasized that healthcare management education in Turkey is bad in terms of quality. In this theme, expert opinions were given under the five headings as "Education quality", "practical education", "branching", "curriculum" and "grade of education".
Epidemiology of sepsis and its various characteristics in a tertiary care adult-multidisciplinary ICU in South India: a retrospective study

Background: The incidence of sepsis is increasing, especially in elderly populations with more comorbidities. It is now estimated that sepsis is a leading cause of mortality and critical illness worldwide. The Epidemiological data regarding sepsis, septic shock and organ involvement is mainly from western literature. Data from India, especially south India, are less when compared to western data. In this background authors conducted a retrospective study in tertiary care hospital in south India. Objectives of the study was epidemiology of sepsis and its various characteristics in a tertiary care adult-Multi disciplinary ICU in South India. Methods: This study was a retrospective observational study, conducted during the time period of June 2016 and May 2017. The study population was patients above 18 yrs admitted in MDICU with sepsis. The study was conducted in a tertiary care adult -Multidisciplinary ICU in South India. Various characteristics like age group, comorbidities, organ involvement, septic shock, sofa score, need for ventilatory support, RRT support and outcome data was collected. Results: In this study, 497 patients who satisfied the Surviving Sepsis Campaign guidelines were included. The majority of the patients (59.8%) were male; the majority was above 60 yr (range 18 to 92 yr). 76.3% Patients had comorbid disease. Hypertension was the most common co-morbid (62%) followed by diabetes mellitus (51.3%). Chronic Kidney Disease was found in 132 patients (26.6%) and Coronary artery disease in 121 patients (24.3%). 186 patients (46.5%) had single organ involvement 140(35%) patients had 2 organ involvement. 74(18.5%) patients had more than 2 organ involvement. Septic shock was found in 155 patients (31.2%). Renal involvement was the most common organ involvement found in 279 patients(59.9%). Most common source for sepsis was the respiratory system found in 230 patients (46.3%), followed by urinary tract infection in 117 patients (23.5%). The study shows a significant association between SOFA score and mortality (p-value 0.001) 52% of mortality happened in group of patients with SOFA score more than 15 and mortality was 28 % in group with a SOFA score of 10-15. Conclusions: In this retrospective study of sepsis, authors found that the most common source of sepsis was pneumonia (46.3%) followed by urinary tract infection (23.5%). Majority of the patients had one organ involvement (46.5%). Among the organ involvement, Acute Kidney injury was the most common organ involvement (56.1%) followed by septic shock (31.2%) and respiratory support (29.6%). Mortality in this study was higher with higher SOFA score.
SNP-based soybean variety selection

One of the main tools in soybean variety selection is analyzing data from yield testing. While most of the tested varieties never come to commercialization, some commercialized varieties are tested in the small number of testing fields. Current Marker-assisted selection (MAS) strategies are focused on major quantitative trait locus (QTL), whereas yield has the complex inheritance that is controlled by multiple QTL with minor effect on phenotype [14]. With the machine learning, yield potential can be efficiently predicted using high dimensional single nucleotide polymorphisms (SNP) markers of varieties. Therefore predicted yield potential could enable better allocation of varieties in testing fields, reducing the number of commercialization of unsuccessful varieties and reducing costs of production. This paper will examine data from Syngenta AI Challenge [4, 9] and the effectiveness of Gradient Boosted Regression Trees for predicting yield potential from SNP markers.
Protecting a Full-Scale Nb3Sn Magnet with CLIQ, the New Coupling-Loss Induced Quench System

A new protection system for superconducting magnets called CLIQ (Coupling-Loss Induced Quench system) was recently developed at CERN. Recent tests on Nb-Ti coils showed that CLIQ is a valid, efficient, and promising method for the protection of high magnetic-field superconducting magnets. However, the protection of new-generation Nb3Sn accelerator magnets is even more challenging due to the much higher stored energy per unit volume and to the significantly larger enthalpy needed to initiate and propagate a normal zone in such coils. Now the CLIQ system is tested for the first time on a Nb3Sn magnet in the CERN magnet test facility in order to investigate its performance in practice thereby validating the method for this type of superconducting magnets as well. Furthermore, we successfully reproduced the electro-thermal transients during a CLIQ discharge. Finally, the implementation of various CLIQ-based protection schemes for the full-scale Nb3Sn quadrupole magnet for the LHC high luminosity upgrade is discussed. The impact of key system parameters on CLIQ performance and the advantages and drawbacks of using multiple CLIQ units on a single magnet are discussed. Index Terms — accelerator magnet, circuit modeling, quench protection, superconducting coil
MAFA-AS1, a long non-coding RNA, predicts for poor survival of hepatocellular carcinoma

Background Hepatocellular carcinoma (HCC) is a common cancer with high morbidity and mortality, especially in East Asia. Reliable biomarkers for HCC are indispensible given the absence of capable prediction of prognosis. Long non-coding RNAs (lncRNAs) are the most abundant products of transcription, which might serve as robust markers for diagnosis or treatment. Methods Multiple bioinformatics tools were utilized to screen indicative lncRNAs for HCC concurrently with the underlying mechanism of its role in tumorigenesis and development. We analyzed the genome-wide alterations and transcriptomics profiles of HCC and non-tumor samples from The Cancer Genome Atlas (TCGA). Survival analyses were also applied. Integrated bioinformatics analyses were applied to identify co-expressed genes along with chromosome loci, predictive RNA binding proteins (RBPs) and co-expressed miRNAs. Results Combining copy number variations (CNVs) with expressions of lncRNAs, 20 most aberrant lncRNAs were identified. MAFA-AS1 was identified as a prognostic indicator of HCC poor overall survival (OS) and disease-free survival (DFS). Multiple bioinformatics analyses suggest that MAFA-AS1 is involved in HCC progression via interacting with SRSF1/SRSF9 and coordinating with miR210. Conclusions MAFA-AS1is a prognostic biomarker for poor OS and DFS of patients with HCC. It is involved in HCC progression.
STUDY ON NOVEL APPROACHES IN INVESTIGATING HIGH PERFORMANCE BIOINFORMATICS TOOL FOR DETECTING GENETIC MUTATIONS INVOLVING SNPS: A DETAILED REVIEW

: This approach being regarded a vital protocol employed for determination of mutation, as there are certain genomic variations determined between individuals. Besides SNPs existed all through the genome which can be subdivided into several groups. Among the various types of SNPs, a non-synonymous SNP in the coding region of a gene is crucial because it modifies the amino acid composition. Consequently, such alterations can have an impact on protein structure, function and cell division. Although, the pin pointing the effects of the many non-synonymous SNPs using biochemical analysis is challenging, computational analysis tools predicting their impact on protein activity and stability have recently developed. Several research articles have stated is effectiveness in identifying the deleterious and disease associated mutations, thus predicting the pathogenic non-synonymous in connection to their functional and structural damaging properties.
Peptide-Functionalized Gold Nanoparticles are Potent Inhibitors of Respiratory Syncytial Virus (RSV) Infection

Human respiratory syncytial virus (RSV) is a major cause of severe upper and lower respiratory tract infections in infants, and in high-risk adults. Currently, there is no vaccine and the available therapeutic agents have limited efficacy. Gold Nanoparticles represent good therapeutic agents due their antibacterial and antiviral properties and an important strategy for efficient delivery of therapeutic agents to maximize therapeutic activity. In the present work, we investigated, in vitro, the potency enhancement of the antiviral activity by functionalization of gold nanoparticle with different anti-RSV peptides targeting the virus entry. Carboxylated Gold nanoparticles of 15 nm diameter size were conjugated with 1) a dendrimeric Heparan Sulfate-Binding Peptide (SB105-A10); and 2) with a small dendrimer-like peptide (T118). SB105-A10 and T118 are known RSV entry inhibitors by competing for binding to cell surface HSPGs and via interactions with RSV fusion protein, respectively. No significant increase (less than 10%) in cell cytotoxicity was observed with nanoparticle concentration up to 100 μg/mL. NPs were allowed to interact respectively with viral particles before infecting the cells as well as interacted with RSV-infected cells. At 30 μg/mL (~ 1.5 nM) concentration, they showed high inhibitory activity of RSV infection and infectivity (>60% inhibition and ≥3-fold reduction of the virus titer). However, when NPs were added in RSV-infected cells, they exhibited less inhibitory activity of RSV (<50% inhibition). Furthermore, the functionalization of Au-NPs with T118 showed an increase of the antiviral activity as compared to non-functionalized nanoparticles. Our results suggest that the functionalization of gold nanoparticles may be effective strategy for the development of broad-spectrum anti-RSV agents inhibiting RSV infection as well as preventing the spread of the virus among already infected cells
THE SPINAL ANESTHESIA AND COMBINED SPINAL EPIDURAL ANESTHESIA VERSUS GENERAL ANESTHESIA FOR CESAREAN SECTION IN SEVERE PREECLAMPSIA: A RANDOMIZED CONTROLLED TRIAL

The article has established the requirements for the organization of the analysis of sustainable development and identifies its structural elements: the purpose, object, subjects and forms that form the conceptual basis for the organization of analysis in the management system of sustainable development of enterprises. Ключові слова: сталий розвиток, економічний аналіз, організація аналізу, аналіз сталого розвитку, концепція, підприємство
A sustainable open data platform for air quality data

Smart Cities need (sensor) data for better decision-making. However, while there are vast amounts of data available about and from cities, an intermediary is needed that connects and interprets sensor data on Web-scale. Today, governments are struggling to publish open data in a sustainable, predictable and cost-effective way. Our research question considers what meth-ods for publishing and archiving linked open data time series, in specific air quality data, are suitable in a sustainable and cost-effective way. Based on a scenario, co-created with various Flemish governmental stakeholders, we benchmarked two Internet of Things reference architectures (FiWare Quantum Leap API and Linked Time Series Server) and calculated the cost for both data publisher and consumer. Results show that applying Linked Times Series on public endpoints for air quality data will lower the cost of publishing and will raise availability because of a better Web caching strategy.
Comparisonof Electrical Performance andStability of Flexible CarbonNanotube Thin Film Transistorsof Different Gate Structures

In this work, fabrication of top, bottom and dual-gate carbon nanotube thin film transistors (CNTTFTs) of different dimensions with single-walled carbon nanotubes (SWCNTs) of99.99% semiconducting purity on a polyimide substrate are reported. Electrical performance comparison of flexible CNTTFTs with different gate structures located at the top, bottom and both at the top and the bottom(dual-gate) of the SWCNTs thin film used as a channel isstudied.Top, bottom, and dual-gate CNTTFTs exhibited p-type behavior. Dual-gate CNTTFTs outperformed the bottom–gate and top-gate CNTTFTs of identical dimensions in on-off current ratio, transconductance, drain conductance, subthreshold slope and mobility. Dual-gate and top-gate CNTTFTs exhibited athreshold shift of less than 1.3V and stability in other electrical performance parameters other than threshold voltage without muchvariation over a time of 60 days exposed to air after fabrication. This work demonstrates that dual-gate CNTTFTs have exhibited better electrical performances and gate control over the channel than the top-gate and bottom-gate CNTTFTs. Dual-gate CNTTFTs are preferred for better electrical performances than top-gate and bottom-gate in flexible applications.
Enhancing the Bug Tossing Graphs and Characteristics of Bug Similarities

_ Abstract: A bug report is typically assigned to a single developer who is then responsible for fixing the bug. Development a new bug firstly is found by developers or users. Then the bug is described as a bug report, which is submitted to a bug repository. Finally the bug trigger checks the bug report and typically assigns a developer to fix the bug. The assignment process is time-consuming and error-prone. Furthermore, a large number of bug reports are tossed (reassigned) to other developers, which increases bug-fix time. In order to quickly identify the fixer to bug reports we present an approach based on the bug tossing history and textual similarities between bug reports. This proposed approach is evaluated on Eclipse and Mozilla. The results show that our approach can significantly improve the efficiency of bug assignment: the bug fixer is often identified with fewer tossing events
Proteomic Identification and Systematic Verification of Biomarkers for Aggressive Prostate Cancer

Despite prostate cancer’s status as the most common cancer to affect men in the Western world, only an estimated 20% of men will die from it. Due to the lack of effective means of prognostication, many men are unnecessarily biopsied and treated. The early and non-invasive identification of lethal disease would have a profound impact on the current practice of prostate cancer management. To this end, the work presented in this thesis describes efforts to characterize proteins in a prostatic fluid known as expressed prostatic secretions (EPS), and to delineate factors in this fluid that demonstrate a high potential as prognostic biomarkers. Using different mass spectrometry-based platforms, I present both a global view of the EPS proteome, as well as targeted, quantitative measures of promising biomarker candidates in this fluid. In order to generate an archive of soluble and secreted factors present in the proteome of EPS, I used shotgun proteomics to analyze direct-EPS and EPS-urine. This led to the identification of over 2000 proteins that comprise the EPS proteome. The data was integrated with other publicly accessible information, such as gene expression profiles and immunohistochemistry images, to characterize this proteome. Furthermore, a collection of prostate-enriched proteins was identified
Early intervention, transition and engagement – interventions to improve the Bolton student journey

This poster will showcase details of an umbrella project at the University of Bolton, UK which involves designing and implementing a series of interventions to understand student transition and engagement, with a view to improving the student journey. The project is designed to improve student transition into Bolton by addressing issues around social integration, engagement, early intervention and assessment of needs and pinpointing the times of year when students experience difficulties. It is also concerned with improving the learner experience and the learning environment. Finally, the project will also seek to understand what factors cause students to withdraw from university. It aims to build upon existing research, both locally and nationally, on academic retention, to understand how we can apply transition pedagogy (Kift & Nelson, 2005) in our own context to build an early intervention model which ensures that students “at risk” of low attainment and attrition are able to access support at the earliest opportunity.
EXPERIMENTAL INVESTIGATIONS TO STUDY THE IONIC CURRENT ENVIRONMENT OF HVDC TRANSMISSION LINES

Corona on power conductors causes the power loss in high voltage transmission system. Not only the power loss, but it is also responsible for generation of space charge Ions, audible noise, television interface etc . Drifting of these space charge ions towards the ground plane in the direction of electric field causes “Ionic current” flow to any living organism which moving under these line conductors Hence it is very important to study the corona generated ionic current environment of high voltage transmission system. In this project, in order to analyses this corona generated ionic current environment completely, an attempt is made to generate and study the corona generated ionic current flow for different line conductor diameters. The proposed project work gives the laboratory model experimental setups to generate the corona phenomenon by using “IGNITION coil” for different electrode configurations. Also the variations of ionic current flow for different line conductor diameter are presented.
Investigating uptake in faecal immunochemical test (FIT) based colorectal cancer screening

Background: This paper describes trends in colorectal cancer incidence, survival and mortality from 1994 to 2010 in Ireland prior to the introduction of population-based screening. Methods: We examined incidence (National Cancer Registry Ireland (NCRI) and mortality (Central Statistics Office) from 1994 to 2010. Age standardised rates (ASR) for incidence and mortality have been calculated, weighted by the European standard population. Annual percentage change was calculated in addition to testing for linear trends in treatment and case fraction of early and late stage disease. Relative survival was calculated considering deaths from all causes. Results: The colorectal cancer ASR was 63.7 per 100,000 in males and 38.7 per 100,000 in females in 2010. There was little change in the ASR over time in either sex, or when colon and rectal cancers were considered separately; however the number of incident cancers increased significantly during 1994-2010 (1752 to 2298). The case fractions of late stage (III/IV) colon and rectal cancers rose significantly over time. One and 5 year relative survival improved for both sexes between the periods 1994-2008. Colorectal cancer mortality ASRs decreased annually from 1994-2009 by 1.8% (95% CI -2.2, -1.4). Rectal cancer mortality ASRs rose annually by 2.4% (95% CI 1.1, 3.6) and 2.8% (95% CI 1.2, 4.4) in males and females respectively. Conclusions: Increases in late-stage disease and rectal cancer mortality demonstrate an urgent need for colorectal cancer screening. However, the narrow age range at which screening is initially being rolled-out in Ireland means that the full potential for reductions in late-stage cancers and incidence and mortality are unlikely to be achieved. While it is possible that the observed increase in rectal cancer mortality may be partly an artefact of cause of death misclassification, it could also be explained by variations in treatment and adherence to best practice guidelines; further investigation is warranted.