Miracle-dz/UniFAR-FTUs huggingface dataset:
Searching for predictors of sense of quality of health: A study using neural networks on a sample of perimenopausal women

Background We assumed that perimenopausal women’s sense of quality of health (SQH) is a subjective evaluation of their psycho-physical health, and comprises three dimensions: sense of quality of life, menopausal symptoms, and the level of positive and negative affect. Purpose The aim of the study was to: 1) test a model about SQH, and 2) explore the role of personality traits, self-esteem, body self, and self-stereotype as predictors of SQH. Methods The sample included 201 women aged between 45 and 55 (50.11±3.07). Participants filled out the Rosenberg Self-Esteem Scale, the Personality Inventory based on the Big Five Factor Model, the Body Self Questionnaire, and a survey querying perimenopausal women’s self-stereotype. To determine the individual SQH dimensions we used the Sense of Quality of Life Questionnaire, the Menopause Symptom List, and the Positive and Negative Affect Schedule. To verify the assumptions of the SQH model and look for SQH predictors we conducted a neural networks analysis with structure optimization via genetic algorithms (a multivariate analysis). Results The SQH model was verified in the course of several neural networks analyses with structure optimization via genetic algorithms (R = 0.849, R2 = 0.723, F = 133,232, p < 0.01). Moreover, we confirmed that SQH comprised three dimensions: quality of life, menopausal symptoms, and affect. SQH and menopausal symptoms were correlated. Similarly, positive and negative affect modified the women’s global sense of quality of life. SQH predictors included: personality traits, self-esteem, the body-self, and menopausal woman’s self-stereotype. Conclusion In practical terms, our findings may help raise awareness among women and medical practitioners, calling for a holistic approach to the health of menopausal women. Our findings may also facilitate the creation of both prevention and therapeutic programs for women transitioning through menopause, for example, cognitive-behavioral therapy.
Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein

The urinary metabolites cyanoethyl mercapturic acid (CEMA) and 3-hydroxypropyl mercapturic acid (3-HPMA) have been widely used as biomarkers of exposure to acrylonitrile and acrolein, respectively, but there are no published data on their consistency over time in the urine of cigarette smokers. We provided, free of charge over a 20 week period, Spectrum NRC600/601 research cigarettes to cigarette smokers in the control arm of a randomized clinical trial of the reduced nicotine cigarette. Urine samples were collected at weeks 4, 8, 12, 16, and 20 and analyzed for CEMA and 3-HPMA, and total nicotine equivalents (TNE) using validated methods. Creatinine-corrected intra-class correlation coefficients for CEMA, 3-HPMA, and TNE were 0.67, 0.46, and 0.68, respectively, indicating good longitudinal consistency for CEMA, while that of 3-HPMA was fair. A strong correlation between CEMA and TNE values was observed. These data support the use of CEMA as a reliable biomarker of tobacco smoke exposure. This is the first report of the longitudinal stability of the biomarkers of acrylonitrile and acrolein exposure in smokers. The data indicate that CEMA, the biomarker of acrylonitrile exposure, is consistent over time in cigarette smokers, supporting its use. While 3-HPMA levels were less stable over time, this biomarker is nevertheless a useful monitor of human acrolein exposure because of its specificity to this toxicant.
Morphology and genetics of Lythrum salicaria from latitudinal gradients of the Northern Hemisphere grown in cold and hot common gardens

The aim of this project was to compare the phenotypic responses of global populations of Lythrum salicaria in cold/dry and hot/humid environments to determine if phenotypic plasticity varied between the native and invasive ranges, and secondarily if this variation was linked to genetic diversity. Common garden studies were conducted in Třeboň, Czech Republic, and Lafayette, Louisiana, USA (cold/dry vs. hot/humid garden, respectively), using populations from latitudinal gradients in Eurasia and North America. Lythrum salicaria seeds collected from the same maternal plants across these latitudinal gradients were germinated and grown in Třeboň and Lafayette. Tissue masses (above-, below-ground, inflorescence and total) of these individuals were assessed at the end of each growing season (2006–2008). Worldwide field measurements of L. salicaria height were made by volunteers from 2004–2016. Biomass and height data were analyzed using the General Linear Model framework and multivariate techniques. Molecular markers (amplified fragment length polymorphisms) of individuals used in the common garden study were analyzed using traditional genetic diversity metrics and Bayesian clustering algorithms in STRUCTURE. Reaction norms were developed from differences in maternal plant responses in Třeboň versus Lafayette. In the common garden studies, stem/leaf, root and total biomass generally were highest for individuals grown from seeds collected in the southern part of the range in the cold garden, particularly by the third year of the study. In contrast, inflorescence biomass in the cold garden was higher by the third year in individuals from mid-latitude populations. As measured by volunteers, plants were taller in Eurasia than in North America moving from north to south with the pattern switching southward of 40°N latitude. Genetic diversity was similar between native and non-native invasive populations regardless of geographical origin of the seed and was not significantly different in the GLM Select model (p > 0.05). Reaction norm slopes showed that Eurasia had larger values than North America for reaction norms for above-ground and total biomass. Plants from the seeds of mother plants from Turkey had wide variation in total biomass when grown in Třeboň versus Lafayette; this variation in response within certain populations may have contributed to the lack of population-level differences in plasticity. These results indicate no loss of genetic diversity for L. salicaria during its North American invasion, nor reduction in plastic tissue allocation responses to a varying environment, which may help explain some of its invasive qualities and which could be of adaptive value under changing future environments.
Performance of sparse-view CT reconstruction with multi-directional gradient operators

To further reduce the noise and artifacts in the reconstructed image of sparse-view CT, we have modified the traditional total variation (TV) methods, which only calculate the gradient variations in x and y directions, and have proposed 8- and 26-directional (the multi-directional) gradient operators for TV calculation to improve the quality of reconstructed images. Different from traditional TV methods, the proposed 8- and 26-directional gradient operators additionally consider the diagonal directions in TV calculation. The proposed method preserves more information from original tomographic data in the step of gradient transform to obtain better reconstruction image qualities. Our algorithms were tested using two-dimensional Shepp–Logan phantom and three-dimensional clinical CT images. Results were evaluated using the root-mean-square error (RMSE), peak signal-to-noise ratio (PSNR), and universal quality index (UQI). All the experiment results show that the sparse-view CT images reconstructed using the proposed 8- and 26-directional gradient operators are superior to those reconstructed by traditional TV methods. Qualitative and quantitative analyses indicate that the more number of directions that the gradient operator has, the better images can be reconstructed. The 8- and 26-directional gradient operators we proposed have better capability to reduce noise and artifacts than traditional TV methods, and they are applicable to be applied to and combined with existing CT reconstruction algorithms derived from CS theory to produce better image quality in sparse-view reconstruction.
Comparative effectiveness of aerobic, resistance, and combined training on cardiovascular disease risk factors: A randomized controlled trial

Although exercise has well-documented health benefits on cardiovascular disease (CVD), the benefit of combination exercise on CVD risk factors in individuals with elevated risk has not been fully elucidated. We compared the effects of aerobic, resistance, and a combination of both aerobic and resistance training on CVD risk factors including peripheral and central BP, cardiorespiratory fitness (CRF), muscular strength, body composition, blood glucose and lipids. Sixty-nine adults (58±7 years) with an elevated blood pressure or hypertension, overweight/obesity, and sedentary lifestyle were randomized to one of the three 8-week exercise programs or a non-exercise control group. Participants in all three exercise groups had an equal total exercise time, 3 days/week (aerobic: 60 minutes/session vs. resistance: 60 minutes/session vs. combination: aerobic 30 minutes/session plus resistance 30 minutes/session). Combined training provided significant reductions in peripheral (-4 mmHg) and central diastolic BP (-4 mmHg), increase in CRF (4.9 ml/kg/min), increase in upper (4 kg) and lower (11 kg) body strength, and increase in lean body mass (0.8 kg) (p <0.05). Aerobic training only increased CRF (7.7 ml/kg/min), and reduced body weight (-1.0 kg) and fat mass (-0.9 kg) (p <0.05). Resistance training only increased lower body strength (13 kg) and reduced waist circumference (-1.7 cm) (p <0.05). However, neither aerobic or resistance training alone showed significant reductions in BP (p>0.05). Furthermore, a composite score of CVD risk factors indicated a greater reduction with combination training compared to the control group. In conclusion, among individuals at an increased risk for CVD, as little as 8-weeks of combined training may provide more comprehensive CVD benefits compared to time-matched aerobic or resistance training alone.
The Mind's Best Work

Over the years, tales about the creative process have flourished-tales of sudden insight and superior intelligence and personal eccentricity. Coleridge claimed that he wrote "Kubla Khan" in one sitting after an opium-induced dream. Poe declared that his "Raven" was worked out "with the precision and rigid consequence of a mathematical problem. " D. N. Perkins discusses the creative episodes of Beethoven, Mozart, Picasso, and others in this exploration of the creative process in the arts, sciences, and everyday life.
Improving cellular automata scheduling through dynamics control

ABSTRACT Cellular automata (CA) are dynamical systems with simple components but at the same time able to generate diverse and complex behaviour. In the present work we employ cellular automata to schedule programs over a multiprocessor system. The previously published CA-based scheduling models: SCAS-HP, SCAS-HP and SCAS-HP differ in the way they control the CA dynamical behaviour. Previous studies indicated that SCAS-HP tends to exhibit an inappropriate CA behaviour, which is mostly based on chaotic rules. Therefore, the parameters and are used to change the dynamical behaviour with the aim of improving the scheduling results. We investigate several instances of the scheduling problem which we split into two families of problems and by addressing each family separately to provide a more accurate evaluation of the models. The first family is formed by programs that solve linear equations by use of the Gaussian Elimination technique, while the second is comprised of artificial instances, which were randomly created in order to stress the scheduling performance of each model. The results indicate that both and can be used to adjust the dynamical behaviour in such models providing better scheduling results. Graphical Abstract
Le ferite della violenza tra paura e terrore.

Le autrici mostrano la continuita esistente tra Dittatura di Stato e Dittatura privata , evidenziando quanto entrambe siano fondate sulla strategia del terrore piu che della paura. Come nei regimi totalitari governati dal terrore e quasi impossibile, senza appoggi economici e socio-politici, articolare il dissenso o la resistenza, cosi il silenzio delle donne vittime di violenza, spesso incomprensibile, e invece un prodotto della passivita impotente che chi esercita la dittatura privata intenzionalmente produce. Le ferite del corpo e della mente sono tali da non promuovere la fuga, come l’emozione della paura potrebbe determinare, bensi la sottomissione coatta e il terrore di morire se si tenta di uscire dalla passivita. Verranno riportate estrapolazioni tratte da interviste a donne che hanno subito violenza all’interno di una relazione coniugale e che si sono rivolte ad un centro antiviolenza del territorio campano dopo molti anni di permanenza nella relazione. Solo in presenza di un legame gruppale puo farsi strada una strategia di resistenza o la possibilita di denuncia. Diventa allora rilevante il ruolo dei luoghi d’ascolto e di strutture protette in cui le donne possano sconfiggere il terrore che aveva disorganizzato pensiero e la parola per uscire dal silenzio con azioni appropriate.
Market Basket Analysis using Association Rule Learning

The proposed paper focusses on the basic concepts of association rule mining and the market basket analysis of different items. In the current study, the market analysis would be done by collecting the real, primary data directly from retailers and wholesalers. The efficiency of the FPGrowth algorithm can be measured in terms of mining of the frequent pattern. Precisely, we apply FP-Growth algorithm on the various data collected from different stores in order to trace the various association rules comprising of a basket. One discrete advantage is that it avoids the generation of candidate sets, which is computationally exhaustive. The results and conclusions drawn can be used in optimizing the market. This will help in predicting future trends and behaviours, allowing businesses to make knowledge-driven decisions.
Photometric Stereo in Participating Media Using an Analytical Solution for Shape-Dependent Forward Scatter

Images captured in participating media such as murky water, fog, or smoke are degraded by scattered light. Thus, the use of traditional three-dimensional (3D) reconstruction techniques in such environments is difficult. In this paper, we propose a photometric stereo method for participating media. The proposed method differs from prvious studies with respect to modeling shape-dependent forward scatter. In the proposed model, forward scatter is described as an analytical form using lookup tables and is represented by spatially-variant kernels. We also propose an approximation of a large-scale dense matrix as a sparse matrix, which enables the removal of forward scatter. We discuss the approximation in the proposed method using synthesized data. Then, experiments with real data demonstrate that the proposed method improves 3D reconstruction in participating media.
Beyond opinion classification: Extracting facts, opinions and experiences from health forums

Introduction Surveys indicate that patients, particularly those suffering from chronic conditions, strongly benefit from the information found in social networks and online forums. One challenge in accessing online health information is to differentiate between factual and more subjective information. In this work, we evaluate the feasibility of exploiting lexical, syntactic, semantic, network-based and emotional properties of texts to automatically classify patient-generated contents into three types: “experiences”, “facts” and “opinions”, using machine learning algorithms. In this context, our goal is to develop automatic methods that will make online health information more easily accessible and useful for patients, professionals and researchers. Material and methods We work with a set of 3000 posts to online health forums in breast cancer, morbus crohn and different allergies. Each sentence in a post is manually labeled as “experience”, “fact” or “opinion”. Using this data, we train a support vector machine algorithm to perform classification. The results are evaluated in a 10-fold cross validation procedure. Results Overall, we find that it is possible to predict the type of information contained in a forum post with a very high accuracy (over 80 percent) using simple text representations such as word embeddings and bags of words. We also analyze more complex features such as those based on the network properties, the polarity of words and the verbal tense of the sentences and show that, when combined with the previous ones, they can boost the results.
Re-designing materials for biomedical applications: from biomimicry to nature-inspired chemical engineering

Gathering inspiration from nature for the design of new materials, products and processes is a topic gaining rapid interest among scientists and engineers. In this review, we introduce the concept of nature-inspired chemical engineering (NICE). We critically examine how this approach offers advantages over straightforward biomimicry and distinguishes itself from bio-integrated design, as a systematic methodology to present innovative solutions to challenging problems. The scope of application of the nature-inspired approach is demonstrated via examples from the field of biomedicine, where much of the inspiration is still more narrowly focused on imitation or bio-integration. We conclude with an outlook on prospective future applications, offered by the more systematic and mechanistically based NICE approach, complemented by rapid progress in manufacturing, computation and robotics. This article is part of the theme issue ‘Bioinspired materials and surfaces for green science and technology’.
Microbial contamination and tissue procurement location: A conventional operating room is not mandatory. An observational study

Background Standard operating rooms (SOR) are assumed to be the best place to prevent microbial contamination when performing tissue procurement. However, mobilizing an operating room is time and cost consuming if no organ retrieval is performed. In such case, non-operating dedicated rooms (NODR) are usually recommended by European guidelines for tissue harvesting. Performing the tissue retrieval in the Intensive care unit (ICU) when possible might be considered as it allows a faster and simpler procedure. Objective Our primary objective was to study the relationship between the risk of microbial contamination and the location (ICU, SOR or NODR) of the tissue retrieval in heart-beating and non-heart-beating deceased donors. Materials and method We retrospectively reviewed all deceased donors’ files of the local tissue banks of Montpellier and Marseille from January 2007 to December 2014. The primary endpoint was the microbial contamination of the grafts. We built a multivariate regression model and used a GEE (generalized estimating equations) allowing us to take into account the clustered structure of our data. Results 2535 cases were analyzed involving 1027 donors. The retrieval took place for 1189 in a SOR, for 996 in a hospital mortuary (NODR) and for 350 in an ICU. 285 (11%) microbial contaminations were revealed. The multivariate analysis found that the location in a hospital mortuary was associated with a lower risk of contamination (OR 0.43, 95% CI [0.2–0.91], p = 0.03). A procurement performed in the ICU was not associated with a significant increased risk (OR 0.62, 95% CI [0.26–1.48], p = 0.4). Conclusion According to our results, performing tissue procurement in dedicated non-sterile rooms could decrease the rate of allograft tissue contamination. This study also suggests that in daily clinical practice, transferring patients from ICU to SOR for tissue procurement could be avoided as it does not lead to less microbial contamination.
Red deer in Iberia: Molecular ecological studies in a southern refugium and inferences on European postglacial colonization history

The red deer (Cervus elaphus) is a widespread wild ungulate in Europe that has suffered strong anthropogenic impacts over their distribution during the last centuries, but also at the present time, due its economic importance as a game species. Here we focus on the evolutionary history of the red deer in Iberia, one of the three main southern refugial areas for temperate species in Europe, and addressed the hypothesis of a cryptic refugia at higher latitudes during the Last Glacial Maximum (LGM). A total of 911 individuals were sampled, genotyped for 34 microsatellites specifically developed for red deer and sequenced for a fragment of 670 bp of the mitochondrial (mtDNA) D-loop. The results were combined with published mtDNA sequences, and integrated with species distribution models and historical European paleo-distribution data, in order to further examine the alternative glacial refugial models and the influence of cryptic refugia on European postglacial colonization history. Clear genetic differentiation between Iberian and European contemporary populations was observed at nuclear and mtDNA levels, despite the mtDNA haplotypes central to the phylogenetic network are present across western Europe (including Iberia) suggesting a panmictic population in the past. Species distribution models, fossil records and genetic data support a timing of divergence between Iberian and European populations that overlap with the LGM. A notable population structure was also found within the Iberian Peninsula, although several populations displayed high levels of admixture as a consequence of recent red deer translocations. Five D-loop sub-lineages were found in Iberia that belong to the Western European mtDNA lineage, while there were four main clusters based on analysis of nuclear markers. Regarding glacial refugial models, our findings provide detailed support for the hypothesis that red deer may have persisted in cryptic northern refugia in western Europe during the LGM, most likely in southern France, southern Ireland, or in a region between them (continental shelf), and these regions were the source of individuals during the European re-colonization. This evidence heightens the importance of conserving the high mitochondrial and nuclear diversity currently observed in Iberian populations.