Miracle-dz/UniFAR-FTUs huggingface dataset:
Realistic Reference for Evaluation of Vehicle Safety Focusing on Pedestrian Head Protection Observed From Kinematic Reconstruction of Real-World Collisions

Head-to-vehicle contact boundary condition and criteria and corresponding thresholds of head injuries are crucial in evaluation of vehicle safety performance for pedestrian protection, which need a constantly updated understanding of pedestrian head kinematic response and injury risk in real-world collisions. Thus, the purpose of the current study is to investigate the characteristics of pedestrian head-to-vehicle contact boundary condition and pedestrian AIS3+ (Abbreviated Injury Scale) head injury risk as functions of kinematic-based criteria, including HIC (Head Injury Criterion), HIP (Head Impact Power), GAMBIT (Generalized Acceleration Model for Brain Injury Threshold), RIC (Rotational Injury Criterion), and BrIC (Brain Injury Criteria), in real-world collisions. To achieve this, 57 vehicle-to-pedestrian collision cases were employed, and a multi-body modeling approach was applied to reconstruct pedestrian kinematics in these real-world collisions. The results show that head-to-windscreen contacts are dominant in pedestrian collisions of the analysis sample and that head WAD (Wrap Around Distance) floats from 1.5 to 2.3 m, with a mean value of 1.84 m; 80% of cases have a head linear contact velocity below 45 km/h or an angular contact velocity less than 40 rad/s; pedestrian head linear contact velocity is on average 83 ± 23% of the vehicle impact velocity, while the head angular contact velocity (in rad/s) is on average 75 ± 25% of the vehicle impact velocity in km/h; 77% of cases have a head contact time in the range 50–140 ms, and negative and positive linear correlations are observed for the relationships between pedestrian head contact time and WAD/height ratio and vehicle impact velocity, respectively; 70% of cases have a head contact angle floating from 40° to 70°, with an average value of 53°; the pedestrian head contact angles on windscreens (average = 48°) are significantly lower than those on bonnets (average = 60°); the predicted thresholds of HIC, HIP, GAMBIT, RIC, BrIC2011, and BrIC2013 for a 50% probability of AIS3+ head injury risk are 1,300, 60 kW, 0.74, 1,470 × 104, 0.56, and 0.57, respectively. The findings of the current work could provide realistic reference for evaluation of vehicle safety performance focusing on pedestrian protection.
Enhanced Flavonoid Accumulation Reduces Combined Salt and Heat Stress Through Regulation of Transcriptional and Hormonal Mechanisms

Abiotic stresses, such as salt and heat stress, coexist in some regions of the world and can have a significant impact on agricultural plant biomass and production. Rice is a valuable crop that is susceptible to salt and high temperatures. Here, we studied the role of flavanol 3-hydroxylase in response to combined salt and heat stress with the aim of better understanding the defensive mechanism of rice. We found that, compared with wild-type plants, the growth and development of transgenic plants were improved due to higher biosynthesis of kaempferol and quercetin. Furthermore, we observed that oxidative stress was decreased in transgenic plants compared with that in wild-type plants due to the reactive oxygen species scavenging activity of kaempferol and quercetin as well as the modulation of glutathione peroxidase and lipid peroxidase activity. The expression of high-affinity potassium transporter (HKT) and salt overly sensitive (SOS) genes was significantly increased in transgenic plants compared with in control plants after 12 and 24 h, whereas sodium-hydrogen exchanger (NHX) gene expression was significantly reduced in transgenic plants compared with in control plants. The expression of heat stress transcription factors (HSFs) and heat shock proteins (HSPs) in the transgenic line increased significantly after 6 and 12 h, although our understanding of the mechanisms by which the F3H gene regulates HKT, SOS, NHX, HSF, and HSP genes is limited. In addition, transgenic plants showed higher levels of abscisic acid (ABA) and lower levels of salicylic acid (SA) than were found in control plants. However, antagonistic cross talk was identified between these hormones when the duration of stress increased; SA accumulation increased, whereas ABA levels decreased. Although transgenic lines showed significantly increased Na+ ion accumulation, K+ ion accumulation was similar in transgenic and control plants, suggesting that increased flavonoid accumulation is crucial for balancing Na+/K+ ions. Overall, this study suggests that flavonoid accumulation increases the tolerance of rice plants to combined salt and heat stress by regulating physiological, biochemical, and molecular mechanisms.
Modeling a complex antenna on a handheld telephone close to human tissue

Design-development and performance evaluation of antennas on handheld telephones can be done experimentally or numerically. Numerical modeling approach or a combination of experiment and numerical modeling, offer many advantages compared with purely experimental approach, which has been often used till now. However, modeling poses many challenges and in order to be considered reliable has to be verified. In this work, modeling of an antenna consisting of two helices is verified by a comparison with measurements made in the laboratory of the handset manufacturer, and by use of two different computer codes. The numerical method used in this investigation is the finite difference time domain (FDTD). A comparison of the measured (in manufacturer's laboratory) electric and magnetic field in four planes at distances 1-4 cm from the antenna with the computed values shows agreement within 15% (which corresponds to the uncertainty in measurements). This agreement is for two operational positions of the antenna in free space. Performance of the handset antenna in the vicinity of the user's head is evaluated. Investigations include the input impedance, far-field radiation pattern and power deposited in the human tissue. The influences of the ear shape and various positions of the handset with respect to the user's head have been evaluated.
Multi-Component Thermal Fluid Injection Performance in Recovery of Heavy Oil Reservoirs

Field observations discern that the oil production rate decreases substantially and water cut increases rapidly with the increase of steam injection cycles. Compared with steam drive, the advantage of flue gas (also called multi-component thermal gas) co-injection with steam is that flue gas can increase the reservoir pressure and expand the heating chamber. In this paper, the flue gas generated by fuel burning in the field was injected with steam to improve heavy oil recovery. This technique was investigated in the large laboratory 3D model and implemented in the field as well. The huff-n-puff process efficiency by flue gas, steam, and flue gas–steam co-injection was compared in the experiments. The field practice also demonstrated that the addition of non-condensable gas in the steam huff-n-puff process recovered more oil than steam alone. The temperature profile in the wellbore with flue gas injection is higher than that with steam injection since the low thermal conductivity of N2 reduces the heat loss. With the increase of stimulation cycles, the incremental oil recovery by flue gas injection declines significantly.
Mel Log Spectrum Approximation (MLSA) filter for speech synthesis

The spectral envelope of speech can be represented efficiently by the log magnitude spectrum on the nonlinear frequency scale, which is close to mel scale (called mel-log spectrum). the mel cepstrum defined by its Fourier coefficients is also considered to have a suitable property as the parameter to represent the spectral envelope. So far, no satisfactory filter has been reported for the synthesis approximating the mel-log spectrum. This paper presents a method of constructing the mel-log spectrum approximation (MLSA) filter, which has a relatively simple structure and a low coefficient sensitivity, together with a design example of MLSA filter for speech synthesis. the transfer function of MLSA filter is represented by Pade approximation, which approximates the exponential of the transfer function of the filter (so-called basic filter). Since the transfer function of the basic filter is represented by a polynomial with the transfer function of the first-order all-pass filter as the variable, it is necessary in the realization of the filter to delete from the feedback loop the path without a delay. By the construction method of MLSA filter shown in this paper, the path without delay can easily be deleted from the feedback loop in the MLSA filter. the obtained MLSA filter is of relatively simple structure and has low coefficient sensitivity. the quantization characteristics of the coefficient are also satisfactory.
The Influence Exerted by Time Frames on Consumers’ Willingness to Buy Nearly Expired Food

With the development of Internet e-commerce channels, online shopping platforms have become the main channel for consumers to buy nearly expired food. Date labels, as one of the main external clues, play a decisive role in nearly expired food purchasing. Therefore, based on attention-related theory, this study attempts to explore the influence exerted by different time frames on consumers’ willingness to buy and its mechanism. The results show that compared with the date, consumers have a higher willingness to buy nearly expired food when the expiration time is framed by delay. More specifically, compared to the date, the delay causes the individual to have a longer time perception, thus more preference for nearly expired food. Meanwhile, the mediating effect of time perception is moderated by food type. The conclusion of this research is helpful to expand the theoretical framework of time frames and related fields on nearly expired food, as well as provide practical guidance for marketers to effectively promote nearly expired food.
Neural Measures of Pitch Processing in EEG Responses to Running Speech

Linearized encoding models are increasingly employed to model cortical responses to running speech. Recent extensions to subcortical responses suggest clinical perspectives, potentially complementing auditory brainstem responses (ABRs) or frequency-following responses (FFRs) that are current clinical standards. However, while it is well-known that the auditory brainstem responds both to transient amplitude variations and the stimulus periodicity that gives rise to pitch, these features co-vary in running speech. Here, we discuss challenges in disentangling the features that drive the subcortical response to running speech. Cortical and subcortical electroencephalographic (EEG) responses to running speech from 19 normal-hearing listeners (12 female) were analyzed. Using forward regression models, we confirm that responses to the rectified broadband speech signal yield temporal response functions consistent with wave V of the ABR, as shown in previous work. Peak latency and amplitude of the speech-evoked brainstem response were correlated with standard click-evoked ABRs recorded at the vertex electrode (Cz). Similar responses could be obtained using the fundamental frequency (F0) of the speech signal as model predictor. However, simulations indicated that dissociating responses to temporal fine structure at the F0 from broadband amplitude variations is not possible given the high co-variance of the features and the poor signal-to-noise ratio (SNR) of subcortical EEG responses. In cortex, both simulations and data replicated previous findings indicating that envelope tracking on frontal electrodes can be dissociated from responses to slow variations in F0 (relative pitch). Yet, no association between subcortical F0-tracking and cortical responses to relative pitch could be detected. These results indicate that while subcortical speech responses are comparable to click-evoked ABRs, dissociating pitch-related processing in the auditory brainstem may be challenging with natural speech stimuli.
The Key Factors for the Fate and Transport of Petroleum Hydrocarbons in Soil With Related in/ex Situ Measurement Methods: An Overview

Once petroleum hydrocarbons (PHs) are released into the soil, the interaction between PHs and soil media is dependent not only upon the soil properties but also on the characteristics of PHs. In this study, the key factors influencing the interactions between PHs and soil media are discussed. The key factors include: 1) the characteristics of PHs, such as volatility and viscosity; and 2) soil properties, such as porosity, hydraulic properties and water status, and organic matter; and 3) atmospheric circumstances, such as humidity and temperature. These key factors can be measured either ex-situ using conventional laboratory methods, or in situ using portable or handheld instruments. This study overviews the current ex/in situ techniques for measuring the listed key factors for PH contaminated site assessments. It is a tendency to apply in situ methods for PH contaminated site characterisation. Furthermore, handheld/portable Fourier transform infrared spectroscopy (FTIR) instrument provides tremendous opportunities for in-field PH contaminated site assessment. This study also reviewed the non-destructive FTIR spectroscopy analysis coupling with handheld FTIR for in-field PH contaminated site characterisation, including determining the concentration of total PH, dominant PH fractions and soil key properties for PH transport modelling.
A Human Gesture Mapping Method to Control a Multi‐Functional Hand for Robot‐Assisted Laparoscopic Surgery: The MUSHA Case

This work presents a novel technique to control multi-functional hand for robot-assisted laparoscopic surgery. We tested the technique using the MUSHA multi-functional hand, a robot-aided minimally invasive surgery tool with more degrees of freedom than the standard commercial end-effector of the da Vinci robot. Extra degrees of freedom require the development of a proper control strategy to guarantee high performance and avoid an increasing complexity of control consoles. However, developing reliable control algorithms while reducing the control side’s mechanical complexity is still an open challenge. In the proposed solution, we present a control strategy that projects the human hand motions into the robot actuation space. The human hand motions are tracked by a LeapMotion camera and mapped into the actuation space of the virtualized end-effector. The effectiveness of the proposed method was evaluated in a twofold manner. Firstly, we verified the Lyapunov stability of the algorithm, then an user study with 10 subjects assessed the intuitiveness and usability of the system.
Retrospective Robot-Measured Upper Limb Kinematic Data From Stroke Patients Are Novel Biomarkers

Background: The efficacy of upper-limb Robot-assisted Therapy (ulRT) in stroke subjects is well-established. The robot-measured kinematic data can assess the biomechanical changes induced by ulRT and the progress of patient over time. However, literature on the analysis of pre-treatment kinematic parameters as predictive biomarkers of upper limb recovery is limited. Objective: The aim of this study was to calculate pre-treatment kinematic parameters from point-to-point reaching movements in different directions and to identify biomarkers of upper-limb motor recovery in subacute stroke subjects after ulRT. Methods: An observational retrospective study was conducted on 66 subacute stroke subjects who underwent ulRT with an end-effector robot. Kinematic parameters were calculated from the robot-measured trajectories during movements in different directions. A Generalized Linear Model (GLM) was applied considering the post-treatment Upper Limb Motricity Index and the kinematic parameters (from demanding directions of movement) as dependent variables, and the pre-treatment kinematic parameters as independent variables. Results: A subset of kinematic parameters significantly predicted the motor impairment after ulRT: the accuracy in adduction and internal rotation movements of the shoulder was the major predictor of post-treatment Upper Limb Motricity Index. The post-treatment kinematic parameters of the most demanding directions of movement significantly depended on the ability to execute elbow flexion-extension and abduction and external rotation movements of the shoulder at baseline. Conclusions: The multidirectional analysis of robot-measured kinematic data predicts motor recovery in subacute stroke survivors and paves the way in identifying subjects who may benefit more from ulRT.
Natural Bioactive Compounds of Sechium spp. for Therapeutic and Nutraceutical Supplements

Natural products are in great demand because certain secondary metabolites (SMs) are sources of antioxidants, flavorings, active substances, or anticancer agents with less aggressiveness and selectivity, among which triterpenes and flavonoids are of importance because they inhibit carcinogenesis. For Sechium spp. P. Br. (chayotes), there is scientific evidence of antiproliferative activity that has occurred when cancer cell lines have been treated with this fruit. In order to compare future therapeutic designs and identify new and ancestral characteristics, triterpenes and flavonoids were determined in contrasting Sechium genotypes. The obtained data were analyzed via a cladistics approach, with the aim of identifying the characteristics and state of phytochemicals and genetic variables. The concentrations of flavonoids and triterpenes were determined, and a more complex composition of secondary metabolites was found in the wild types as compared to their domesticated genotypes. Bitter fruits contained a higher number of SMs, followed by those with a neutral and sweet flavor. A cladogram showed the differentiation of the three groups based on the flavor of the fruits. The diversity of SMs decreases in evolutionary terms, in response to domestication and environmental adaptation. Therefore, genotypes can be feasibly selected based on fruit flavor for gross-breeding, and cytotoxicity can be reduced without losing possible therapeutic effects.
Association of the Polygenic Risk Score With the Probability of Prodromal Parkinson’s Disease in Older Adults

Several studies have investigated the association of the Parkinson’s disease (PD) polygenic risk score (PRS) with several aspects of well-established PD. We sought to evaluate the association of PRS with the prodromal stage of PD. We calculated PRS in a longitudinal sample (n = 1120) of community dwelling individuals ≥ 65 years from the HELIAD (The Hellenic Longitudinal Investigation of Aging and Diet) study in order to evaluate the association of this score with the probability of prodromal PD or any of the established risk and prodromal markers in MDS research criteria, using regression multi-adjusted models. Increases in PRS estimated from GWAS summary statistics’ ninety top SNPS with p < 5 × 10–8 was associated with increased odds of having probable/possible prodromal PD (i.e., ≥ 30% probability, OR = 1.033, 95%CI: 1.009–1.057 p = 0.006). From the prodromal PD risk markers, significant association was found between PRS and global cognitive deficit exclusively (p = 0.003). To our knowledge, our study is the first population based study investigating the association between PRS scores and prodromal markers of Parkinson’s disease. Our results suggest a strong relationship between the accumulation of many common genetic variants, as measured by PRS, and cognitive deficits.
Early Positive Approaches to Support (E-PAtS) for Families of Young Children With Intellectual Disability: A Feasibility Randomised Controlled Trial

Background: Parents of children with intellectual disabilities are likely to experience poorer mental well-being and face challenges accessing support. Early Positive Approaches to Support (E-PAtS) is a group-based programme, co-produced with parents and professionals, based on existing research evidence and a developmental systems approach to support parental mental well-being. The aim of this study was to assess the feasibility of community service provider organisations delivering E-PAtS to parents/family caregivers of young children with intellectual disability, to inform a potential definitive randomised controlled trial of the effectiveness and cost-effectiveness of E-PAtS. Methods: This study was a feasibility cluster randomised controlled trial, with embedded process evaluation. Up to two parents/family caregivers of a child (18 months to <6 years old) with intellectual disability were recruited at research sites and allocated to intervention (E-PAtS and usual practise) or control (usual practise) on a 1:1 basis at cluster (family) level. Data were collected at baseline and 3 and 12 months' post-randomisation. The following feasibility outcomes were assessed: participant recruitment rates and effectiveness of recruitment pathways; retention rates; intervention adherence and fidelity; service provider recruitment rates and willingness to participate in a future trial; barriers and facilitating factors for recruitment, engagement, and intervention delivery; and feasibility of collecting outcome measures. Results: Seventy-four families were randomised to intervention or control (n = 37). Retention rates were 72% at 12 months post-randomisation, and completion of the proposed primary outcome measure (WEMWBS) was 51%. Recruitment of service provider organisations and facilitators was feasible and intervention implementation acceptable. Adherence to the intervention was 76% and the intervention was well-received by participants; exploratory analyses suggest that adherence and attendance may be associated with improved well-being. Health economic outcome measures were collected successfully and evidence indicates that linkage with routine data would be feasible in a future trial. Conclusions: The E-PAtS Feasibility RCT has demonstrated that the research design and methods of intervention implementation are generally feasible. Consideration of the limitations of this feasibility trial and any barriers to conducting a future definitive trial, do however, need to be considered by researchers. Clinical Trial Registration: https://www.isrctn. com, identifier: ISRCTN70419473.
Epitope-Based Vaccine of a Brucella abortus Putative Small RNA Target Induces Protection and Less Tissue Damage in Mice

Brucella spp. are Gram-negative, facultative intracellular bacteria that cause brucellosis in humans and animals. Currently available live attenuated vaccines against brucellosis still have drawbacks. Therefore, subunit vaccines, produced using epitope-based antigens, have the advantage of being safe, cost-effective and efficacious. Here, we identified B. abortus small RNAs expressed during early infection with bone marrow-derived macrophages (BMDMs) and an apolipoprotein N-acyltransferase (Int) was identified as the putative target of the greatest expressed small RNA. Decreased expression of Int was observed during BMDM infection and the protein sequence was evaluated to rationally select a putative immunogenic epitope by immunoinformatic, which was explored as a vaccinal candidate. C57BL/6 mice were immunized and challenged with B. abortus, showing lower recovery in the number of viable bacteria in the liver, spleen, and axillary lymph node and greater production of IgG and fractions when compared to non-vaccinated mice. The vaccinated and infected mice showed the increased expression of TNF-α, IFN-γ, and IL-6 following expression of the anti-inflammatory genes IL-10 and TGF-β in the liver, justifying the reduction in the number and size of the observed granulomas. BMDMs stimulated with splenocyte supernatants from vaccinated and infected mice increase the CD86+ marker, as well as expressing greater amounts of iNOS and the consequent increase in NO production, suggesting an increase in the phagocytic and microbicidal capacity of these cells to eliminate the bacteria.