Miracle-dz/UniFAR-FTUs huggingface dataset:
Prenatal and Breast Milk Morphine Exposure Following Maternal Intrathecal Morphine Treatment

A case of an infant who had morphine exposure during and following pregnancy while her mother was treated with intrathecal (IT) morphine is presented along with a review of the relevant literature. Successful maternal pain management was achieved during pregnancy and while breastfeeding. Minimal maternal serum and breast milk levels in the first 7 postpartum weeks were found. Also, infant sleep and arousal behavior and general development at 2 and 7 months were unremarkable, illustrating the possible safe and efficacious use of IT morphine during and following pregnancy. Further work is required to understand opioid pharmacology during breastfeeding, which will be used to develop an empirical approach to breastfeeding and morphine use.
The Double-Edged Sword of Rewards for Participation in Psychology Experiments

This quasi-experimental study examined participation rates and sample characteristics of participants recruited with and without the offer of course credit. In Sample 1, where course credit is not usually offered, credit was added in one condition (N =195) and not in the other (N = 175). In Sample 2, where credit is usually offered, it was maintained in one condition (N = 92) and removed in the other (N = 178). Results in both samples revealed that participation rates were higher in the credit conditions; they plunged when customary rewards were taken away. Results also revealed evidence of sample bias. More specifically, the motivational characteristics of participants and nonparticipants differed in all conditions except the new credit condition. Resume
Spontaneous endometriosis in rhesus macaques: evidence for a genetic association with specific Mamu-A1 alleles

Abstract Endometriosis is a poorly understood common debilitating women's reproductive disorder resulting from proliferative and ectopic endometrial tissue associated with variable clinical symptoms including dysmenorrhea (painful menstrual periods), dyspareunia (pain on intercourse), female infertility, and an increased risk of malignant transformation. The rhesus macaque (Macaca mulatta) develops a spontaneous endometriosis that is very similar to that seen in women. We hypothesized that specific major histocompatibility complex (MHC) alleles may contribute to the pathogenesis of endometriosis. As part of a collaboration between the Biomedical Primate Research Centre (BPRC) in the Netherlands and the New England Primate Research Center (NEPRC) in the United States, we analyzed DNA sequences of MHC class I (Macaca mulatta, Mamu-A1) and class II (Mamu-DRB) alleles from rhesus macaques with endometriosis and compared the allele frequencies with those of age-matched healthy macaques. We demonstrate that two MHC class I alleles are overrepresented in diseased macaques compared to controls: Mamu-A1*001, 33.3 % in BPRC animals with endometriosis vs. 11.6 % in healthy macaques (p= 0.007), and Mamu-A1*007, 21.9 % NEPRC rhesus macaques vs. 6.7 %, (p= 0.003). We provide evidence that select MHC class I alleles are associated with endometriosis in rhesus macaques and suggest that the disease pathogenesis contribution of MHC class I warrants further research.
Critical points and reaction paths characterization on a potential energy hypersurface

Most of the time, the definitions of minima, saddle points or more generally order p (p=0,…,n) critical points, do not mention the possibility of having zero Hessian eigenvalues. This feature reflects some flatness of the potential energy hypersurface in a special eigendirection which is not often taken into account. Thus, the definitions of critical points are revisited in a more general framework within this context. The concepts of bifurcation points, branching points, and valley ridge inflection points are investigated. New definitions based on the mathematical formulation of the reaction path are given and some of their properties are outlined.
Adaptive stochastic control of linear systems with random parameters

Abstract : This thesis investigates the adaptive stochastic control of linear dynamic systems with purely random parameters. Hence there is no posterior learning about the system parameters. The control law is non-dual; still it has the qualitative properties of an adaptive control law. In the perfect measurement case, the control law is modulated by the priori level of uncertainty of the system parameters. Optimal stochastic control of dynamic systems with uncertain parameters has certain limitations. For the linear-quadratic optimal problem, the infinite horizon solution does not exist if the parameter uncertainty exceeds a certain quantifiable threshold. By considering the discounted cost problem, we have obtained some results on optimality versus stability for this class of stochastic control problems. For the noisy sensor measurement case the optimal fixed structure estimator-controller is obtained. The control law requires the solution of a coupled nonlinear two-point boundary value problem. Computer simulations of the forward and backward difference equations provided some insight into the uncertainty threshold for the closed loop system.
Mammographic density is the main correlate of tumors detected on ultrasound but not on mammography

Although mammography screening programs do not include ultrasound examinations, some diagnostic units do provide women with both mammography and ultrasonography. This article is concerned with estimating the risk of a breast cancer patient diagnosed in a hospital‐based mammography unit having a tumor that is visible on ultrasound but not on mammography. A total of 1,399 women with invasive breast cancer from a hospital‐based diagnostic mammography unit were included in this retrospective study. For inclusion, mammograms from the time of the primary diagnosis had to be available for computer‐assisted assessment of percentage mammographic density (PMD), as well as Breast Imaging Reporting and Data System (BIRADS) assessment of mammography. In addition, ultrasound findings were available for the complete cohort as part of routine diagnostic procedures, regardless of any patient or imaging characteristics. Logistic regression analyses were conducted to identify predictors of mammography failure, defined as BIRADS assessment 1 or 2. The probability that the visibility of a tumor might be masked at diagnosis was estimated using a regression model with the identified predictors. Tumors were only visible on ultrasound in 107 cases (7.6%). PMD was the strongest predictor for mammography failure, but age, body mass index and previous breast surgery also influenced the risk, independently of the PMD. Risk probabilities ranged from 1% for a defined low‐risk group up to 40% for a high‐risk group. These findings might help identify women who should be offered ultrasound examinations in addition to mammography.
Aging with HIV and disability: The role of uncertainty

Due to advances in treatment, people with HIV are living longer and developing disabilities related to the virus, adverse side effects of medications, and aging. Illness-related uncertainty has been shown to contribute to disablement; however, there is little understanding of the uncertainties related to aging with HIV. The purpose of this research was to describe the contribution of uncertainty to the disability experienced by older adults living with HIV. Forty-nine men and women living with HIV and 50 years or older participated in in-depth qualitative interviews exploring various aspects of social participation and disability. Transcriptions of the interviews were analyzed using a grounded theory approach. Age-related uncertainties were described in the following themes: source of health challenge; health providers' age-related knowledge and skills; financial uncertainty; transition to retirement; appropriate long-term housing, and uncertainty over who would care for them. While not directly attributable to aging, the episodic nature of HIV left many with uncertainties related to when their next episode of illness would occur and often resulted in an inability to plan in advance. Results highlight the need to focus on the notion of successful and positive aging with the view to identifying effective interventions that reduce disability and enhance the overall health of older adults with HIV. This work builds on previous studies highlighting the role of uncertainty in the disability experience by identifying age-related components specific to older adults aging with HIV.
Multi physical field coupling calculation of airflow characteristics of SF6 circuit breaker based on actual gas model

The Redlich-Kwong state equation of the real gas and the governing equations of the flow field were combined to solve the problem. The distribution of physical parameters of the interrupter was attained under the condition of the circuit breaker in small capacitive current interruption by analysis of the 126kV capacitor group SF6 gas circuit breaker arc extinguishing chamber in air flow field, which is according to enthalpy flow arc model and dynamic model of non-equilibrium arc energy built by microscopic parameters of plasma. The dielectric recovery characteristic curves in arc contacts after the arc extinguished were attained through the coupling calculation in the field of electric and gas flow. Calculation results show that: When the circuit breaker is opening the small capacitive current, the effect of breaking speed on arc burning time is very small and arc extinguished in advance. The arc gap conductivity is about 700S/m, and the thermal conductivity is about 1.1W/m-K at arc extinguishing time. The transient recovery voltage is always lower than that of the breakdown voltage, and the electric arc can successfully break without reburning. To make the short arcing time have a large arc distance, and the large nozzle should be open enough to be strong for the gas blowing condition, the optimum opening speed is 9.6m/s.
A Coalition Approach to Higher-Level Fusion

Abstract : This paper outlines a collaborative program of work in higher-level fusion being conducted between Australia, Canada, the United States, and the United Kingdom under the auspices of a TTCP panel on Information fusion. The paper shows how work from the four nations has been integrated through a common scenario, which the panel proposes to subsequently offer as a benchmarking scenario for the higher-level fusion community.
Conductivity and Hall coefficient in La2CuO4+y near the insulator-metal transition.

Measurements are reported of the conductivity, its anisotropy, and the in-plane Hall coefficient for a single crystal of La/sub 2/CuO/sub 4+/ital y// with /ital y/ varied from 0%--1.5%. The conductivity is thermally activated with a single activation energy at high temperatures and with a continuously decreasing activation energy below /similar to/50 K. The anisotropy is as large as 500 at high temperatures, falls sharply to 10--20 at /similar to/50 K, and then is only weakly /ital T/ dependent at lower temperatures. The Hall coefficient is simply activated above /similar to/50 K (with an activation energy similar to that of the in-plane conductivity), and has a peak at lower temperatures. All these features are evidence for a change in the transport mechanism near 50 K. The low-temperature conductivity is consistent with thermally assisted tunneling between localized states at the Fermi energy. The high-temperature process arises from thermal activation of carriers into a band of highly anisotropic states. The low mobility associated with these states makes it impossible, however, to determine whether they arise from impurities or are states near a band or mobility edge.
The lower limb in people with diabetes Position statement of the Australian Diabetes Society

Diabetic lower‐limb problems result in significant social, medical and economic consequences and are the most common cause of hospitalisation for people with diabetes. In people with diabetes, amputations are 15 times more common than in people without diabetes, and 50% of all amputations occur in people with diabetes. Peripheral neuropathy, vascular disease, infection and deformity of the feet are the major predisposing factors leading to ulceration or amputation. All people with diabetes should receive basic footcare education, and regular foot examinations. The risk for the development of ulceration can be assessed by basic clinical examination of the foot. Management strategies depend on the risk category, and range from basic education and annual review to specialist care by a multidisciplinary team.
An inventory problem

As a systems analysis trainee with the Iota Beta Mu Corporation, you have been assigned to assist the manager of the Invisible Machine Department with his problem of product control. Since he is versed in modeling, he has prepared the following conditions:1. One day's demand is independent of earlier days' demand.
Beyond Wand and Glove Based Interaction

We introduce a freehand interaction device that provides directed tactile feedback to the user’s hand. The basic idea is to enhance the user’s six degree of freedom interaction within virtual or augmented environments by offering an additional three dimensional tactile feedback as an immediate response from the virtual world. We describe the prototype system TACTool, which utilizes vibro motors as actuators in combination with optical tracking in an integrative design. The prototype has been tested within a collision sensitive virtual reality application.
DDoS Attacks Classification using Numeric Attribute-based Gaussian Naive Bayes

Cyber attacks by sending large data packets that deplete computer network service resources by using multiple computers when attacking are called Distributed Denial of Service (DDoS) attacks. Total Data Packet and important information in the form of log files sent by the attacker can be observed and captured through the port mirroring of the computer network service. The classification system is required to distinguish network traffic into two conditions, first normal condition, and second attack condition. The Gaussian Naive Bayes classification is one of the methods that can be used to process numeric attribute as input and determine two decisions of access that occur on the computer network service that is “normal” access or access under “attack” by DDoS as output. This research was conducted in Ahmad Dahlan University Networking Laboratory (ADUNL) for 60 minutes with the result of classification of 8 IP Address with normal access and 6 IP Address with DDoS attack access.
Exploring intercellular signaling by proteomic approaches

Cells live in a close social context by having mutual communication with their local microenvironment. This complex intercellular communication activates dynamic signaling pathways and regulates specific cell fate. MS‐based proteomics has been approved to be inevitable for characterizing dynamic protein expression and PTMs on a global scale. However, because of technical difficulties for targeting membrane receptors and secreted proteins, especially in a physiologically relevant manner, systematic characterization of intercellular signaling by MS‐based proteomics has largely lagged behind. Here, I will review the latest proteomics technology development and its application to characterizing different modes of intercellular communication including indirect and direct cell–cell communication, and protein translocalization. I will discuss how MS‐based proteomics has been applied for systems‐level profiling intercellular signaling in defined biological contexts including tumor microenvironment, bacteria/virus–host cell interaction, immune cell interaction, and stem cell niche.
279 km, 591 Mb/s direct detection transmission experiment using four in-line semiconductor optical amplifiers

The authors realized a direct detection intensity-modulation system experiment with four cascaded in-line semiconductor optical amplifiers. Using optical isolators between the amplifiers, they transmitted a NRZ 2/sup 23/-1 message over a distance of 279 km at a bit rate of 591.2 Mb/s. A comparison of this result with parallel experiments without optical isolators indicates that for a realistic implementation of long distance systems with semiconductor optical amplifiers, interamplifier optical isolators will be needed unless the residual facet reflectivity of the optical amplifiers is brought to a very low value (<1*10/sup -4/). <<ETX>>
Tissue transglutaminase as the autoantigen of coeliac disease

Dieterich et al show that immunoprecipitation of human fibrosarcoma cell lysates (cell line HT1080) using the IgA fraction from serum samples of patients with coeliac disease results in a single protein band with a molecular weight of 85 kDa. Immunoprecipitation occurred exclusively with 25 coeliac disease serum samples, but with none of the 25 control samples. The 85 kDa antigen was cleaved with endoproteinase Asp-N, and after amino-terminal sequence analysis, the three cleavage products tested all yielded sequences that could be assigned to tissue transglutaminase (EC 2.3.2.13; tTG). In order to prove that tTG obtained from the fibrosarcoma cells binds to the endomysial antibody fraction of coeliac serum IgA, the authors performed indirect immunofluorescence with high titre coeliac disease serum samples on monkey oesophagus with or without prior incubation of those samples with a commercially available tTG extract (Sigma, Deisenhofer, Germany). Pretreatment with tTG almost completely abolished endomysial antibody labelling. Also, when the Sigma tTG was used as antigen in an enzyme linked immunosorbent assay (ELISA), 12 coeliac disease patient samples but none of the seven control serum samples displayed increased IgA immunoreactivity. Dieterich et al conclude they have identified tTG as the unknown endomysial autoantigen.
Integration of Sustainability Issues in Strategic Transportation Planning: A Multi‐criteria Model for the Assessment of Transport Infrastructure Plans

Abstract: Last decades have witnessed significant advances in transportation planning methodologies, facilitated by the development of computational algorithms, technologies, spatial modeling tools—such as geographical information systems (GIS) and decision support systems (DSS). However, at strategic planning levels, a commonly accepted assessment model integrating the sustainability paradigm is still lacking. This work presents a novel contribution to this research line, with the proposal of a multi‐criteria assessment model embedded in a GIS. The criteria have been designed covering the three dimensions of sustainability: economic, social, and environmental. This assessment model constitutes an interdisciplinary approach tightly linking network analysis, spatial geography, regional economic, and environmental issues in a GIS‐based computer framework. The validity of the methodology is tested with its application in a case study: the extension of the high speed rail (HSR) network included in the Spanish Transport and Infrastructure Plan 2005‐2020 (PEIT).
Is Subchondral Acetabular Edema or Cystic Change on MRI a Contraindication for Hip Arthroscopy in Patients With Femoroacetabular Impingement?

Background: The outcome for arthroscopic treatment of femoroacetabular impingement (FAI) can worsen with increasing arthritis. However, there remains a subset of hips with relatively maintained joint space but with acetabular subchondral edema and cystic change with unknown outcome on magnetic resonance imaging (MRI). Purpose: (1) To correlate MRI findings of subchondral acetabular edema/cystic change with arthroscopy grading of articular cartilage and (2) to determine whether postoperative outcome was worse for patients with subchondral edema/cystic change compared with a matched control group. Study Design: Cohort study; Level of evidence, 3. Methods: The records of all patients who underwent arthroscopic hip surgery for FAI at a single institution between 2007 and 2013 were reviewed for subchondral edema/cyst on preoperative MRI. Lesions were characterized by grade using an established classification system and were correlated with arthroscopic articular cartilage changes. A matched cohort of patients without evidence of subchondral edema or cyst was identified. Minimum 2-year outcomes were compared using prospectively collected Hip Outcome Score (HOS) activities of daily living and sport subscales as well as the modified Harris Hip Score (mHHS). Results: Overall, 104 patients were included. Thirty-six patients (18 men, 18 women) with a mean age of 41 years (range, 19-67 years) had subchondral edema, with or without the presence of cystic acetabular changes, at minimum 2-year follow-up (range, 24-60 months). Two patients who underwent total hip replacement were excluded in the outcome score comparison. Thirty-one of 34 patients (91%) had a grade 4 full-thickness cartilage lesion at the time of diagnostic arthroscopy. The mean mHHS was inferior for all patients with subchondral edema/cystic change (79.9 ± 18.7 vs 86.6 ± 12.5; P = .03), and the HOS was also lower (69.1 ± 27.0 vs 79.5 ± 21.4; P = .02). The overall success rate was 67% for all patients with subchondral edema/cystic change compared with 85% in the control group (P = .04). Conclusion: The presence of a subchondral edema with an acetabular cyst on MRI is indicative of a full-thickness cartilage lesion at the time of arthroscopy. These patients have inferior outcomes for arthroscopic treatment of FAI compared with patients with similar age and activity level without MRI subchondral cystic changes.
Fearing the feline: domestic cats reduce avian fecundity through trait-mediated indirect effects that increase nest predation by other species

Summary 1. Urban areas contain high densities of non-native species, which in the UK include the domestic cat Felis catus (Linnaeus 1758) and the grey squirrel Sciurus carolinensis (Gmelin 1788). The direct predation effects of domestic cats on prey populations attract intense debate, and such influences of the nest-predatory grey squirrel are receiving increasing attention. In contrast, theory predicts that sublethal and indirect effects are more important, but empirical evidence is currently lacking. 2. We conducted controlled model presentation experiments at active urban blackbird Turdus merula (Linnaeus 1758) nests to provide the first empirical evidence that quantifies the potential sublethal and indirect effects of predators (domestic cat and grey squirrel) on avian reproductive success. 3. Domestic cat models reduced subsequent parental provisioning rates, a strong indicator of sublethal effects, by one-third relative to a nonpredatory rabbit Oryctolagus cuniculus (Linnaeus 1758) control. There was no compensatory increase in food load size. Previous experiments demonstrate that this magnitude of reduced food delivery will reduce nestling growth rates by c. 40%. The grey squirrel model induced similar but weaker effects. 4. Following the brief presence of the domestic cat model, subsequent daily nest predation rates, chiefly by corvids, increased by an order of magnitude relative to the squirrel and rabbit models. The intensity of parental nest defence elicited in response to model presentations predicts the probability of such third-party predator predation events, and the domestic cat model generated significant increases in nest defence behaviour. 5. Synthesis and applications. The brief presence of a domestic cat at avian nest sites reduces subsequent provisioning rates and induces lethal trait-mediated indirect effects. We provide the first robust evidence for these latter effects in any avian predator–prey system, although they are likely to be common in many avian assemblages with high predator densities. It is imperative that future assessments of the impact of predatory species on avian prey species take lethal trait-mediated indirect effects into account, as so doing will prevent biased estimates of predator effects and facilitate the design of more effective control strategies. Full mitigation of the sublethal and indirect effects of domestic cats would problematically require permanent indoor housing.