Miracle-dz/UniFAR-FTUs huggingface dataset:
Emerging indocyanine green-integrated nanocarriers for multimodal cancer therapy: a review

Nanotechnology is a branch of science dealing with the development of new types of nanomaterials by several methods. In the biomedical field, nanotechnology is widely used in the form of nanotherapeutics. Therefore, the current biomedical research pays much attention to nanotechnology for the development of efficient cancer treatment. Indocyanine green (ICG) is a near-infrared tricarbocyanine dye approved by the Food and Drug Administration (FDA) for human clinical use. ICG is a biologically safe photosensitizer and it can kill tumor cells by producing singlet oxygen species and photothermal heat upon NIR irradiation. ICG has some limitations such as easy aggregation, rapid aqueous degradation, and a short half-life. To address these limitations, ICG is further formulated with nanoparticles. Therefore, ICG is integrated with organic nanomaterials (polymers, micelles, liposomes, dendrimers and protein), inorganic nanomaterials (magnetic, gold, mesoporous, calcium, and LDH based), and hybrid nanomaterials. The combination of ICG with nanomaterials provides highly efficient therapeutic effects. Nowadays, ICG is used for various biomedical applications, especially in cancer therapeutics. In this review, we mainly focus on ICG-based combined cancer nanotherapeutics for advanced cancer treatment.
Aggregative capacity of experimental anchored Fish Aggregating Devices (aFADs) in Northeastern Brazil revealed through electronic tagging data

Catches of pelagic fish associated to anchored Fish Aggregating Devices have been responsible for increases in income, fish consumption, and even cultural identity of artisanal fishing communities in many developing countries worldwide. Nonetheless, in Brazil, aFAD fishing is still poorly developed and studied. In this experiment, FADs were anchored offshore the city of Recife (Northeastern Brazil) to investigate the potential of moored buoys in the aggregation of commercially important pelagic species near the coast, as an alternative fishing site for artisanal fishers. The behavior of acoustically tagged fish was investigated to assess whether they were attracted to the FADs and how long they remained associated to them. The results indicated that, although economically important species were found near the FADs, they did not remain associated for long periods. From the four species tagged, Acanthocybium solandri, Coryphaena hippurus, Thunnus atlanticus , and Caranx crysos , only the two latter were detected at the FADs. Both species presented a preference for a specific FAD, with stronger site fidelity being recorded for C. crysos . This species presented Total Resident Times (TRTs) of more than a month and continuous residence times of more than 14 consecutive days. T. atlanticus , on the other hand, remained around the buoys for short time intervals, with a maximum TRT of only two days. Short diurnal excursions far from the FADs and few longer excursions during nighttime were recorded for C. crysos . These results do not support the possible use of moored FADs near the coast of Recife as an alternative fishing site for artisanal fisheries. It is possible that the geomorphological characteristics of the experimental area did not favor the aggregative behavior of large pelagic fish species, such as tunas, around FADs.
Outdoor risky play

Playing outdoors offers rich play opportunities and has unique characteristics less apparent in indoor play, including taking physical risks. Risky play occurs when children intentionally seek exhilarating and scary physical play situations that allow them to gain mastery over their fears. Opportunities for outdoor risky play have been severely curtailed in recent generations. As research mounts on the importance of risky play for children’s health, development and well-being, there is increasing recognition regarding the need for action to create supportive environments for play. This chapter reviews the literature on the importance of risky play. It then presents the three key ingredients for outdoor risky play supportive environments – time, space and freedom – and suggests practice and policy necessary to implement sustained and meaningful change.
Engineering Elizabethkingia meningoseptica sp. F2 for Vitamin K2 production guided by genome analysis.

Background The species in family Elizabethkingia meningoseptica are interesting strain for investigating Vitamin K2 metabolic analysis. However, their genomic sequence, metabolic pathway, potential abilities, and evolutionary status are still unknown. Results This study therefore aimed to perform a genome sequencing of Elizabethkingia meningoseptica sp. F2 and further accomplished comparative analysis with other Vitamin K2 strains reveals overall identifying its unique/shared metabolic genes across genomes. The 3,874,794–base pair sequence of Elizabethkingia meningoseptica sp. F2 is presented. Of 3,539 genes annotation was applied. Results of synteny block demonstrated Elizabethkingia meningoseptica sp. F2 shares high levels of synteny with Elizabethkingia meningoseptica ATCC 13253 and Elizabethkingia meningoseptica NBRC 12535. Identification of Vitamin K2 metabolic pathway in Elizabethkingia meningoseptica sp. F2 were also accomplished. In addition, Elizabethkingia meningoseptica sp. F2 was resistant to gentamicin, streptomycin, ampicillin and caramycin, consistent with the presence of multiple genes encoding diverse multidrug efflux pump protein in the genome. Furthermore, By co-overexpression experiments of MenA and MenG, we showed that Vitamin K2 content was enhanced by 37% compared with control strain. Conclusions The genome analysis of Elizabethkingia meningoseptica sp. F2 in conjunction with the comparative metabolic pathways analysis among the E.coli, Bacillus subtilis and Streptomyces provided a useful information on the Vitamin K2 biosynthetic pathway and other related pathways at systems level.
Description of a Brain Neuropeptidome of the Malaria Vector Nyssorhynchus Albimanus and Neuropeptide Differential Expression During Infection with Plasmodium Berghei

Background Insect neuropeptides, mainly synthesized in the brain, play a central role in the control of many physiological processes. A neuropeptidome of the mosquito Nyssorhynchus albimanus was described based in a comparative analysis of the mosquito genome complemented with high-throughput sequencing of brain transcriptomes. In addition, neuropeptides differentially expressed during Plasmodium infection were identified.Results We identified 3,811 transcripts associated to translation, oxidation-reduction process, protein binding, ATP binding, integral components of membrane and ribosome, among others. We identified 29 neuropeptide transcripts that predicted at least 60 biopeptides, including pyrokinin, glycoprotein hormone alpha (GPA2), prothoracicotropic hormone, neuropeptide-like precursor 1 (NPLP1), allatostatin C, orcokinin, corazonin, adipokinetic hormone I, SIFamide, pyrokinin capa-like, pigment-dispersing factor, adipokinetic hormone/corazonin-related peptide (ACP), tachykinin-related peptide, trissin, neuropeptide F, short neuropeptide F (sNPF), diuretic hormone 31, bursicon, crustacean cardioactive peptide (CCAP), allatotropin, allatostatin 1, partner of bursicon (PBURS), ecdysis triggering hormone (ETH), diuretic hormone 44 (Dh44), insulin-like peptides 5, 1, 3, 7, 2 (ILPs) and eclosion hormone (EH) and seven neuropeptide receptors. Transcript mapping to the Ny. albimanus genome provided evidence for the re-annotation of the myosuppressin gene. A quantitative analysis documented increased expression of adipokinetic hormone/corazonin-related peptide, pyrokinin and corazonin in the mosquito brain after Plasmodium berghei infection.Conclusion This work represents an initial effort to characterize the neuropeptide repertoire of Ny. albimanus and provides new information for understanding neuroregulation of the mosquito response during Plasmodium infection .
A six-channel microstrip diplexer for multi-service wireless communication systems

In this paper, a six-channel microstrip diplexer is designed and fabricated. It operates at 0.75/0.85/1/1.25/1.6/1.8 GHz for multi-service wireless communication systems. It consists of two stub-loaded resonators, which are integrated by coupled lines. The channels are close together, which makes the proposed diplexer suitable for frequency division duplex (FDD) schemes. The proposed structure has a compact size of 0.025 λg2 where λg is the guided wavelength calculated at 0.75 GHz. The other advantages of the introduced multi-channel diplexer are the low insertion losses of 1.62/1.27/0.43/0.53/1.26 and 1 dB, as well as good return losses of 26/26/25/25/21.7 and 22 dB at 0.75/0.85/1/1.25/1.6/1.8 GHz respectively. A good isolation of less than 22 dB is obtained between the channels. In order to design the presented diplexer a designing technique is used which is based on the proposing of an equivalent approximated LC model and calculating the inductors and capacitors. To confirm the simulation results, the introduced diplexer is fabricated and measured.
Effects of bupivacaine infiltration for controlling post-tonsillectomy pain: A systematic review and meta-analysis

Objective: In this study, we attempt to address these limitations and provide the current state of evidence evaluating the influence of bupivacaine during a tonsillectomy. To demonstrate the effects of bupivacaine during tonsillectomy on the visual analog scale score, mean operative procedure duration, and the onset of postoperative morbidities. Data source: A systematic identification of literature was performed according to PRISMA guidelines on four academic databases: MEDLINE, Scopus, EMBASE, and CENTRAL. Review methods: A meta-analysis compared the influence of bupivacaine and normal saline administered during tonsillectomy on the visual analog scale score, duration of the operation and postoperative morbidities. Results: Out of 1,427 records, 18 articles including 729 participants (mean age: 10.2 ± 6.7 years) were included in this review. This systematic review presents a 1b level of evidence supporting the use of bupivacaine during tonsillectomy to reduce the amount of perceived level of pain, duration of the operation and postoperative morbidity as compared to normal saline. The meta-analysis reveals beneficial effects for bupivacaine interventions by demonstrating small to large effect reduction on visual analog scale score (Hedge’s g: -1.47), mean duration of operative procedure (-1.35), and incidence of postoperative morbidity (-0.23) as compared to placebo groups using normal saline. Conclusion: The current systematic review and meta-analysis recommend the administration of bupivacaine with tonsillectomy as compared to normal saline. The review reports beneficial effects of bupivacaine’s administration as compared to normal saline for reducing the perceived level of pain, duration of operation, and postoperative morbidity.
Efficacy and Safety of Hydroxychloroquine and Chloroquine for Treating COVID-19: A Rapid Review

Background: Since its emergence, COVID-19 has affected more than one million people with over 100,000 deaths globally as of early April 2020. In this review, we evaluated the efficacy and safety of hydroxychloroquine and chloroquine on patients with COVID-19. Methods: PubMed, CENTRAL, Google Scholar, Chinese Clinical Trial Registry and Trial Registers: ISRCTN; UMIN-CTR (Japan's Trial Register); and the WHO portal up were searched for the in vitro and in vivo studies of hydroxychloroquine and chloroquine.Results: Moderate-certainty evidence from a single published RCT to-date showed that after a five-days treatment, patients on hydroxychloroquine may have shorter symptom duration compared to the control group, including fever (MD-1.0 day (95% CI -1.48, -0.52), cough (MD -1.1 day (95% CI -1.63, -0.57) and higher likelihood of having improved chest CT appearance (RR 1.47 (95% CI 1.02, 2.11), no clear differences was observed in the risk of progressing to severe illness and risk of adverse effects. A single non-randomized study showed marked decreased in the number with positive viral load at day 6, but due to several flaws in the study, the certainty of evidence for the outcome was very low.Conclusion: Despite the evidence on possible effects of hydroxychloroquine and chloroquine, given the paucity of available evidence especially in relation to the number on-going RCTs, conclusion on the effectiveness and safety of hydroxychloroquine cannot yet be made.
Dual-Input Nonisolated DC–DC Converter With Vehicle-to-Grid Feature

Electric vehicles (EVs) have become a more prominent solution to replace all fossil-fuel-based combustion vehicles. During the parking of EVs, the power produced by solar photovoltaic (PV) present in the PV-powered EVs is underutilized when the capacity of the EV battery is full. Also, a converter is devoted in the conventional EVs to perform the vehicle-to-grid (V2G) or vehicle-to-vehicle (V2V) operation. To use PV and to perform V2G operation, a novel nonisolated dual-input single-output dc–dc converter (DISOC) is proposed. The DISOC structure can be reconfigured to perform six types of operation based on the status of power availability with PV, battery, and also the running status of the EV. Simultaneous power transfer from both the input sources, charging the battery from solar PV, and V2G and G2V operations are the key features of the proposed converter. The converter operation, component design, effect of parasitic elements on the converter performance, small-signal model, and so on have been reported. The hardware prototype of the converter is fabricated for 500 W, and the experimental results are presented.
Degradation of Lithium Ion Batteries under Complex Conditions of Use

Abstract It is well known that lithium ion batteries degrade due to cycling (cycle life), but also when in standby mode with little or no current throughput (calendar life). Experimental results exist which show the lifetime of a battery under either of these conditions, cycling or standby operation. Results for an application specific mix of cycling and standby operation are, however, not readily available in the scientific literature. The ageing mechanisms of these two modes of operation differ in their impact on capacity and internal resistance as the two most important performance characteristics of a battery. The question is how the ageing mechanisms interact and how certain ageing mechanisms occurring particularly in one mode of operation affect ageing mechanisms which occur predominantly in the other mode of operation. As the conditions of use are very different in terms of current amplitude, state-of-charge and temperature, it is clear that the interaction needs to be considered taking the application into account by using application specific load collectives. This paper will discuss how to approach this problem, shows first results and their relevance for vehicle batteries when used for vehicle to grid operation.
An intelligent optimisation algorithm for vehicle path planning based on underground parking systems

With the increasing number of vehicles, many large shopping malls, office buildings, hotels, stations, etc., are paying more and more attention to the construction of underground parking lots. Parking areas are constantly being expanded, and large underground parking lots are emerging. However, traditional parking management systems are aging and no longer meet the needs of today's society, thus creating the problem of parking difficulties in large underground parking lots. In this paper, a model of a large underground parking lot is constructed using MAKLINK graph theory firstly, and then, a parking path planning algorithm based on Dijkstra algorithm and Ant Colony algorithm is proposed. Finally, we set up in an experimental setting on MATLAB with multiple scenarios to verify the superiority of the proposed algorithm, which provides new ideas for parking in large underground parking lots.
Ondes capillaires à une interface fluide fonctionnalisée : détection micromécanique de brins d'ADN

Quel que soit le contexte biotechnologique ou biomoleculaire, les biopuces se sont rapidement imposees comme systeme de detection de molecules biologiques. Le concept recent de biopuce fluide, qui consiste a capturer les molecules d'interet a une interface fluide fonctionnalisee, offre entre autres perspectives la possibilite d'utiliser, comme diagnostic micromecanique, les changements de rheologie interfaciale induits par l'hybridation entre molecules cibles et molecules sondes. La pertinence d'un tel moyen de detection pour des sequences d'ADN, est etudiee experimentalement. Un reseau d'ondes capillaires de menisque est engendre a la surface d'une sous-phase aqueuse, contenue dans un recipient cylindrique agite verticalement. Le reseau d'ondes, dont la geometrie est caracterisee conjointement par deux techniques optiques non intrusives, montre a la fois une sensibilite a la tension de surface et aux proprietes rheologiques interfaciales, qui subissent une evolution differente en presence de brins d'ADN hybrides ou non hybrides.
Optimal Simultaneous PWM Control for Three- Phase Dual-Active-Bridge Converters to Minimize Current Stress in the Whole Load Range

In order to reduce the current stress and improve the efficiency of three-phase dual-active-bridge (3p-DAB) converters in the whole load range, in this article, a simplified derivation based on a segmented analytical method is proposed to obtain an optimal simultaneous pulsewidth-modulation (PWM) control scheme. First, the average transferred power and the current stress of the 3p-DAB at different modes can be calculated based on the segmented analytical method. Second, in the light of the expressions of current stress and average transferred power of the 3p-DAB, the current stress minimization problem can be transferred into inequality constraints’ issues for different modes. The optimization process is derived step by step and the closed-form analytic expression of the optimal control strategy is presented. Then, a simple table of the global optimal control scheme that minimizes the current stress under buck or boost operating scenarios can be obtained. Furthermore, a closed-loop control structure is designed to implement the optimal simultaneous PWM control in practice. Finally, experimental comparison with existing modulation schemes has been implemented on a laboratory prototype to verify the theoretical analysis and the outstanding performance of the proposed strategy.
Heart structure, serum cholesterol, and adiposity of rats treated with a hypercaloric diet: effectiveness of Citrus sinensis (L.) Osbeck and swimming

Abstract This study evaluated the effects of the herbal medicine red orange (Citrus sinensis (L.) Osbeck) and swimming for 84 days on the animal, heart, and abdominal fat weight and the histomorphometric aspects of heart and total cholesterol of Wistar rats. The rats were divided into seven experimental groups of 12 animals each, consisting of a normocaloric diet (Dn), hypercaloric diet (Dh), normocaloric diet and herbal medicine (DnH), hypercaloric diet and herbal medicine (DhH), normocaloric diet and swimming (DnS), hypercaloric diet and swimming (DhS), and hypercaloric diet, swimming, and herbal medicine (DhSH). The data were analyzed statistically by the Tukey test and considered significant when p<0.05. Groups treated with the normocaloric diet had lower abdominal fat weight. The normocaloric diet and herbal medicine (DnH) provided the smallest thickness of the right ventricle. The hypercaloric diet (Dh) reduced the number of cardiomyocytes and the perimeter of cardiac muscle fibers. Swimming and the red orange extract acted synergistically by reducing the deleterious effects of the hypercaloric diet and increasing the thickness of the cardiac chambers and the number of cardiomyocytes. Only the supplementation with the red orange extract did not reduce abdominal fat in rats treated with a hypercaloric diet. Therefore, red orange alone did not promote beneficial changes in the studied data, but its association with swimming increased the number of cardiomyocytes and thickness of muscle fibers, which could contribute to preventing cardiovascular diseases and maintaining health, as well as the regular swimming and a normocaloric diet, which provided less adiposity.
Study on Regenerative Energy Recovery of Electric Vehicle Through Voltage Control Using Switched Capacitor

When an electric vehicle (EV) is driving at a very low or high speed, there are cases where energy recovery is not possible because the back electromotive force generated in the motor is too small or large. In this paper, we investigate the application of the regenerative electromagnetic retarder's energy recovery method to the permanent magnet synchronous motor (PMSM) of an EV. When the EV was driven downhill or coasts, L-C resonance via switched capacitor was used to control the voltage generated by the PMSM as a voltage that can recharge the battery. During regeneration, the voltage generated in the PMSM varied along with the degree of resonance through switching the duty of the proposed circuit. Through simulation, DC-Link voltage according to switching duty ratio and motor speed is plotted in a 3D map. Based on this, voltage control algorithm using PI and reverse PI duty control has been proposed. To prove the proposed algorithm, the DC-link stage of the inverter is simply equivalent to the R-C model. And, if the PMSM operates at a constant speed, the generated voltage is controlled so as to charge the battery. In addition, the discharging and charging energies of the battery are simulated when the EV with certain load torque is driving uphill and downhill. Considering the dynamics of the car, the energy recovery rate was simulated when the EV is driving uphill and downhill in a 50:50 ratio at the same slope and distance. The simulations were conducted using MATLAB Simulink, and the experiments were carried out using a motor-generator set and a small electric truck equipped with a 13 kW PMSM, respectively.