Miracle-dz/UniFAR-FTUs huggingface dataset:
Boundary matters: clinical leadership and the distinctive disciplinary contribution of nursing to multidisciplinary care.

AIMS To describe Irish nurses' views of clinical leadership and to describe their clinical leadership development needs. BACKGROUND Nurses are often unclear about the precise nature of clinical leadership and its impact on the processes and outcomes of care and little is known about their self-perceived clinical leadership development needs. DESIGN Seventeen focus group interviews were conducted with a purposive sample of 144 nurses from 13 practice settings. A conceptual lens was provided by the work of Bernstein and Young who emphasise the epistemological, practical and relational significance of boundaries and how they relate in fundamental ways to professionals' sense of their distinctive disciplinary identities and membership of specialised communities of practice. METHODS Focus group data were collected using semi-structured topic guides. Analysis was facilitated by NVivo 7© and interpretation was informed by a conceptual framework arising from the interplay of emerging themes and the literature review. RESULTS The implications for clinical leadership development of two critical concepts, 'representing nursing' and 'compensatory action', are discussed in detail. CONCLUSIONS Clinical leadership development should emphasise the development of all nurses as clinical leaders in the context of the delineation, clarification and articulation of their distinctive contribution in multidisciplinary care settings. RELEVANCE TO CLINICAL PRACTICE Clinical leaders are recognised as practice experts and as leaders in their particular fields. Recognition and influence in and beyond the immediate context of care depends greatly on their ability to articulate the distinct nursing contribution to patient care. This ability provides an essential resource to resist the ongoing blurring, effacement and dilution of nurses' roles.
A novel transcutaneous NFC uplink system symbiotic with inductive wireless power supply under ultra low coupling coefficient

A novel near-field communication uplink system is proposed. It uses coils as antennas, coils that are also used for inductive wireless power supply. It is symbiotic with the power supply due to negligible interaction. Using binary phase shift keying, it has a lower bit error rate compared with systems using load shift keying. Furthermore, it is able to communicate under ultra low coupling coefficient. The total power consumption of the implanted transmitter is only 0.6 mW. The external receiver reliably receives less than 10 mV signal under 280 V interference. In experiments, the bit error rate of our uplink system was under 1.0E-07 with coils 70 mm apart, when the power transfer is on.
Applicability of process mining in the exploration of healthcare sequences

Process mining is a widespread methodology for exploring various processes of different sectors. With the help of process mining techniques the limitations and deviations of the real processes can be revealed, and by these means improving steps can be suggested in process management. This methodology can be successfully used in the healthcare domain as well, although there are special features, which make healthcare event sequences unusual. In this work, we give an overview of the difficulties of healthcare process mining, and we point out the main differences of healthcare and industrial processes. Based on these statements, we give recommendations for managing the problems encountered in healthcare process mining and suggest a workflow to generate more precise process models. The recommendations are presented through a case study, in which we analyzed the medical care of colorectal cancer patients.
Remarks on "On a General Class of Multipoint Root-Finding Methods of High Computational Efficiency"

An oversight on the number of function evaluations of the $n$-point root-finding methods proposed in [SIAM J. Numer. Anal. , 47 (2010), pp. 4402-4414] is discussed. To correct this flaw, modified methods of optimal computational efficiency are presented by applying higher-order Hermite interpolatory polynomials.
The method for soil moisture inversion based on ground-based scattering measurement

With the ENVISAT-ASAR Alternating Polarisation mode and the parameter sets of HJ-1C-SAR as the research foundation, using the measurement data by multi-wave bands and multi-polarization ground-based scatterometer, the paper studies an inversion method of bare-surface soil moisture. The studies simultaneously consider the influence which include root-mean-square height S and correlation length L in this method, and combine the two roughness parameters, expressed as a combination of roughness Zs. Using Integral Equation Model (IEM) to analysis the relationship between Zs in different incident angles and the difference of the backscattering coefficients under two wavelengths, establishes the multinomial semi-empirical model for soil moisture inversion under different angles. The model's validation is conformed by the ground-based scattering datas, the results show that, for the medium and low roughness of the bare surface, the error is smaller than 15 percent between inversion value with the model and the measured soil moisture.
Enhancement of Mammographic Features by Optimal Adaptive Neighborhood Image Processing

X-ray mammography is the only breast cancer detection technique presently available with proven efficacy. Mammographic detection of early breast cancer requires optimal radiological or image processing techniques. We present an image processing approach based on adaptive neighborhood processing with a new set of contrast enhancement functions to enhance mammographic features. This procedure brings out the features in the image with little or no enhancement of the noise. We also find that adaptive neighborhoods with surrounds whose width is a constant difference from the center yield improved enhancement over adaptive neighborhoods with a constant ratio of surround to center neighborhood widths.
Analysis of Left Atrial Performance in Patients with Type 2 Diabetes Mellitus without Overt Cardiac Disease and Inducible Ischemia: High Prevalence of Increased Systolic Force Related to Enhanced Left Ventricular Systolic Longitudinal Function

In patients with chronic pressure overload, higher left atrial systolic force (LASF) is associated with high‐risk cardiovascular (CV) phenotype, with increased left ventricular (LV) mass, concentric hypertrophy, and diastolic dysfunction. In hypertension and aortic stenosis, LASF predicts increased rate of CV events independent of traditional risk factors. Moreover, LASF is an independent predictor of heart failure in diabetic and nondiabetic patients. Limited data are available about LASF and its relationship with LV systolic function in type 2 diabetes mellitus (T2DM).
Key Role for Ceramides in Mediating Insulin Resistance in Human Muscle Cells*

Elevated non-esterified fatty acids, triglyceride, diacylglycerol, and ceramide have all been associated with insulin resistance in muscle. We set out to investigate the role of intramyocellular lipid metabolites in the induction of insulin resistance in human primary myoblast cultures. Muscle cells were subjected to adenovirus-mediated expression of perilipin or incubated with fatty acids for 18 h, prior to insulin stimulation and measurement of lipid metabolites and rates of glycogen synthesis. Adenovirus-driven perilipin expression lead to significant accumulation of triacylglycerol in myoblasts, without any detectable effect on insulin sensitivity, as judged by the ability of insulin to stimulate glycogen synthesis. Similarly, incubation of cells with the monounsaturated fatty acid oleate resulted in triacylglycerol accumulation without inhibiting insulin action. By contrast, the saturated fatty acid palmitate induced insulin resistance. Palmitate treatment caused less accumulation of triacylglycerol than did oleate but also induced significant accumulation of both diacylglycerol and ceramide. Insulin resistance was also caused by cell-permeable analogues of ceramide, and palmitate-induced resistance was blocked in the presence of inhibitors of de novo ceramide synthesis. Oleate co-incubation completely prevented the insulin resistance induced by palmitate. Our data are consistent with ceramide being the agent responsible for insulin resistance caused by palmitate exposure. Furthermore, the triacylglycerol derived from oleate was able to exert a protective role in sequestering palmitate, thus preventing its conversion to ceramide.
Impact of the Provider and Healthcare team Adherence to Treatment Guidelines (PHAT-G) intervention on adherence to national obesity clinical practice guidelines in a primary care centre.

RATIONALE, AIMS AND OBJECTIVES Obesity is significantly underdiagnosed and undertreated in primary care settings. The purpose of this clinical practice change project was to increase provider adherence to national clinical practice guidelines for the diagnosis and treatment of obesity in adults. METHODS Based upon the National Institutes of Health guidelines for the diagnosis and treatment of obesity, a clinical change project was implemented. Guided by the theory of planned behaviour, the Provider and Healthcare team Adherence to Treatment Guidelines (PHAT-G) intervention includes education sessions, additional provider resources for patient education, a provider reminder system and provider feedback. RESULTS Primary care providers did not significantly increase on documentation of diagnosis and planned management of obesity for patients with body mass index (BMI) greater than or equal to 30. Medical assistants increased recording of height, weight and BMI in the patient record by 13%, which was significant. CONCLUSIONS Documentation of accurate BMI should lead to diagnosis of appropriate weight category and subsequent care planning. Future studies will examine barriers to adherence to clinical practice guidelines for obesity. Interventions are needed that include inter-professional team members and may be more successful if delivered separately from routine primary care visits.
Detection of flaviviruses by reverse‐transcriptase polymerase chain reaction

RNA sequences of five flaviviruses were detected by a modified polymerase chain reaction (PCR) that incorporated a reverse transcriptase and RNase inhibitor. Oligonucleotide primer pairs were synthesized to amplify sequences from St. Louis encephalitis (SLE), Japanese encephalitis (JBE), yellow fever (YF), dengue 2 (DEN‐2), and dengue 4 (DEN‐4) viruses. The amplified products were visualized as bands of appropriate size on ethidium bromide‐stained agarose gels. The identity of these products was confirmed by restriction endonuclease cleavage to generate fragments of predicted lengths. The reverse transcriptase PCR (RT‐PCR) successfully amplified flavivirus sequences from cell cultures, frozen brain tissue, and formalin‐fixed, paraffin‐embedded brain tissue. The reactions were highly specific, and the method compared favorably to two conventional assays of viral infectivity. RT‐PCR followed by PCR with nesting primers (N‐PCR) was 1,000‐fold more sensitive in detecting virus than classical infectivity titration by intracerebral inoculation of suckling mice and nearly 1,000‐fold more sensitive than amplification of virus in cell culture followed by inoculation of mice.
Detection of web users' opinion from multimodal opinion elements

In this paper we present an approach to identify opinion of web users from opinionated texts and to classify web users opinion into positive or negative. Today web users express their opinion using multimodal opinion elements such as opinion phrases, emoticons and short words. These form of multimodal opinion expressions are very popular and are used by a large number of web users to document their opinion. In this paper we use semantic based approach to find users opinion from multimodal opinion elements like phrases, emoticons and short words. Our approach detects these multimodal opinion elements and uses them to obtain semantic orientation scores. These scores are later used to identify users opinion from opinionated texts. Our approach is effective and provides better results compared to other approaches on different data sets comprising of opinion.
Resection of heterotopic ossification in the adult with head trauma.

Lesions of heterotopic ossification were excised from thirty-seven joints in twenty-three adults who had had injuries to the brain. The lesions were excised from twenty-three elbows, twelve hips, and two shoulders. Patients were retrospectively divided into five categories according to the neural residua (cognitive and physical deficits). The patients in Class I (minimum cognitive and physical disability) and patients in Class II (minimum cognitive disability and moderate physical disability) who had fair or good selective control of the affected extremity had the best prognosis for maintaining the range of motion resulting from resecting the lesion and improving function postoperatively. They also had a low incidence of recurrence of the lesion. Seven of the nine elbows and eight of the eight hips in patients in these classes had successful results. All three of the patients in Class V (severe cognitive and physical deficits) who had a lesion of the hip and all eight of the patients in Class V with poor selective control had a poor result. In the twenty-five joints for which adequate follow-up radiographs were available to determine if the lesion recurred, fourteen recurrences were identified (56 per cent). Eleven of these patients were considered to have a poor result. Nine of the fourteen recurrences occurred in patients in Class V. Radiographic evidence of the maturity of the lesion and a normal level of alkaline phosphatase were of limited importance in predicting a low rate of recurrence. The over-all complications included four superficial infections and no instances of osteomyelitis. (ABSTRACT TRUNCATED AT 250 WORDS)
Blind demixing and deconvolution with noisy data at near optimal rate

Blind demixing and deconvolution refers to the problem of simultaneous deconvolution of several source signals from its noisy superposition. This problem appears, amongst others, in the field of Wireless Communication: Many sensors sporadically communicate only short messages over unknown channels. We show that robust recovery of message and channel vectors can be achieved via convex recovery. This requires that random linear encoding is applied at the devices and that the number of required measurements at the receiver scales essentially with the degrees of freedom of the overall estimation problem. Thus, the scaling is linear in the number of source signals. This significantly improves previous results.
Antioxidant potential of indigenous cyanobacterial strains in relation with their phenolic and flavonoid contents

Abstract Antioxidant activities of eight indigenous cyanobacterial strains belonging to the genera Oscillatoria, Chroococcidiopsis, Leptolyngbya, Calothrix, Nostoc and Phormidium were studied in relation with their phenolic and flavonoid contents, ranging 3.9–12.6 mg GAE g−1 and 1.7–3.44 mg RE g−1. The highest activities were shown by Leptolyngbya sp. SI-SM (EC50 = 63.45 and 67.49 μg mL−1) and Calothrix sp. SI-SV (EC50 = 65.79 and 69.38 μg mL−1) calculated with ABTS and DPPH assays. Significant negative correlations were seen between total phenolic and flavonoid contents and the antioxidant activities in terms of EC50 values. Furthermore, HPLC detected 15 phenolic compounds with total concentrations ranging from 277.3 to 829.7 μg g−1. The prevalent compounds in most of the strains were rutin, tannic acid, orcinol, phloroglucinol and protocatechuic acid. Cyanobacterial strains showed high potential as a good source of phenolic compounds with potent antioxidative potential which could be beneficial for food, cosmetic and pharmaceutical industries.
Wireless temperature sensor integrated circuits with on-chip antennas

Two wireless temperature sensors with on-chip antenna realized in 0. 35µm CMOS technology are presented. The first sensor exploits a double 3-stage ring oscillator structure, which transform the silicon substrate temperature variation into a frequency modulation. The second device is based on a PTAT (proportional to absolute temperature) sensing element, where the base-emitter voltage difference between two diode connected PNP BJT's with different emitter currents is measured.
Detection of Chlamydia pneumoniae but not Helicobacter pylori in atherosclerotic plaques of aortic aneurysms

Recent reports suggest an association between Chlamydia pneumoniae and Helicobacter pylori bacteria and atherosclerosis. We studied 51 patients (mean age, 68.3 years) who underwent abdominal aortic aneurysm surgery. For each patient we performed a microimmunofluorescence test for immunoglobulin G (IgG), IgA, and IgM antibodies to C. pneumoniae specific antigen (TW-183). Anti-H. pylori antibodies were determined by means of an EIA-G test. Each aortic aneurysm surgical specimen was sampled into multiple sections of 0.3 cm2 each and frozen at -20 degrees C. Two samples of each aneurysm were used for a nested PCR with two sets of C. pneumoniae and two sets of H. pylori specific primers. Specimens were treated with a solution containing 20 mM Tris-HCl, Tween 20-Nonidet P-40 (0.5% [vol/vol] each), and 100 micrograms of proteinase K per ml and incubated at 60 degrees C for 1 h and at 98 degrees C for 10 min. DNA was extracted twice with phenol-chloroform-isoamylic alcohol and precipitated with sodium acetate-ethanol by standard methods. Forty-one patients were seropositive for C. pneumoniae with past-infection patterns in 32 patients (16 < or = IgG < 512; 32 < or = IgA < 256) and high antibody titers in 9 patients (IgG > or = 512). In 26 of 51 patients, C. pneumoniae DNA was detected in aortic aneurysm plaque specimens. Of these patients, 23 had a serologic past-infection pattern, 2 had an acute reinfection pattern, and 1 was seronegative. Forty-seven of 51 patients were seropositive for H. pylori. In all cases PCR showed no evidence of H. pylori presence in plaque specimens. This study provides data on a possible C. pneumoniae involvement in the pathogenesis of aortic aneurysm and additional evidence for an association between this agent and atherosclerosis. Conversely, notwithstanding a high H. pylori seroprevalence observed, our results tend to rule out the possibility of a direct involvement of H. pylori in atherosclerosis.
Teacher attitudes towards digitally enabled classrooms in Western Cape government schools

The purpose of this study was to describe and analyse teachers' attitudes and perceptions towards the use of digital resources in the classroom. The data of this study were collected using a qualitative method, whereby a questionnaire was distributed to 45 Life Orientation teachers. The teachers had undertaken training on how to use digital resources, to supplement their traditional approaches. The questionnaire included items relating to the teachers' knowledge and understanding of how to use digital tools to enhance their teaching methods. This research was guided by the cognitive dissonance theory (Festinger, 1957); the study has shown how fears and uncertainties create dissonance among teachers relating to using technology. The study emphasised that the manner in which the digital resources infused into programmes has a direct impact on how teachers embrace or reject these new methods of facilitating teaching.
Novel incremental spectrum sensing method based on sequential tone detection

In this paper, we propose a novel incremental spectrum sensing method based on sequential tone detection. The conventional spectrum sensing algorithm using FFT computes all frequency components in a process, thus it requires unnecessary complexity. To overcome this drawback, sequential spectrum sensing algorithm utilizing DFT was proposed, and it shows almost same detection performance with reduced complexity. The proposed method of this paper utilizes Goertzel algorithm, and it provides improved signal detection performance with further reduced computational complexity compare with the conventional schemes. The simulation results verify that it provides 10% enhancement on detection probability with significantly reduced system complexity.
Doing Fence Sitting

A growing body of research indicates that the way health care professionals conceptualize mental health might have important clinical implications. We adopted a discursive psychology approach to explore clinical psychologists’ accounts of mental health and its effects. Semistructured interviews were conducted with 11 clinical psychologists in the East Midlands region of the United Kingdom. The participants constructed mental health through building up biological factors and psychosocial aspects as opposite ends of the same spectrum, and then positioned themselves as distant from these extremes to manage issues of stake and accountability. A discourse of moral concern for service users was used to negotiate the implications of having different views of mental health from service users, enabling clinicians to manage issues of accountability and demonstrate their ability to be helpful. This suggests that clinicians should be mindful of the effects of their use of language and make the contingent nature of their knowledge explicit.
Overexpression of miR-145–5p Inhibits Proliferation of Prostate Cancer Cells and Reduces SOX2 Expression

ABSTRACT We aimed to perform functional analysis of miR-145–5p in prostate cancer (PCa) cells and to identify targets of miR-145–5p for understanding its role in PCa pathogenesis. PC3, DU145, LNCaP PCa, and PNT1a nontumorigenic prostate cell lines were utilized for functional analysis of miR-145–5p. Its overexpression caused inhibition of proliferation through apoptosis and reduced migration in PCa cells. SOX2 expression was significantly decreased in both mRNA and protein level in miR-145–5p-overexpressed PCa cells. We proposed that miR-145–5p, being an important regulator of SOX2, carries a crucial role in PCa tumorigenesis.
Adaptive heart rate-based epileptic seizure detection using real-time user feedback

Objective: Automated seizure detection in the home environment has attracted increasing interest in recent decades. Heart rate-based seizure detection is a way to detect temporal lobe epilepsy seizures at home, but patient-independent classifiers have been shown to be insufficiently accurate. This is due to the high patient-dependence of heart rate features, whereas this method does not use patient-specific data. Patient-specific classifiers take into account patient-specific data, but often not enough patient data are available for a fully robust patient-specific classifier. Therefore a real-time adaptive seizure detection algorithm is proposed here. Approach: The algorithm starts with a patient-independent classifier, but gradually adapts to the patient-specific characteristics while they are obtained ‘on the go’. This is done by using real-time user feedback to annotate previously generated alarms, causing an immediate update to the used support vector machine classifier. Data annotated as seizures are automatically removed from the updating procedure if their detection would lead to too many false alarms. This is done in order to cope with potentially incorrect feedback. Main results: The adaptive classifier resulted in an overall sensitivity of 77.12% and 1.24 false alarms per hour when applied to over 2833 h of heart rate data from 19 patients with 153 clinical seizures. This is around 30% fewer false alarms compared to a patient-independent classifier with a similar sensitivity. Significance: This low-complexity adaptive algorithm is able to deal well with incorrect feedback, making it ideal for a seizure warning system, and in the future it will also include complementary modalities to improve its performance.