Miracle-dz/UniFAR-FTUs huggingface dataset:
Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases

Significance We provide transcriptomic insights into differences between pediatric and adult T cell acute lymphoblastic leukemia (T-ALL) patients through an international collaborative effort integrating RNA-sequencing data of 707 patients. Ten subtypes were identified, each characterized by distinct gene mutation profiles and dysregulated expression signatures of leukemogenic factors, and associated with T cell development stages. Adult T-ALL tends to have characteristics of early T cell precursor ALL, mostly corresponding to the mixed phenotype acute leukemia, whereas pediatric T-ALL shows a wide spectrum of aberrant molecular features, from early T cell precursor to mature T cell compartments. Our findings have important implications for disease mechanism of T-ALL that differs between pediatric and adult patients, facilitating further refined targeted therapy.
The correlation between clinical and radiological severity of osteoarthritis of the knee

Introduction: Primary osteoarthritis (OA) is a common cause of knee pain. Appropriate management of knee OA is based on clinical and radiological findings. Pain, deformity, and functional impairments are major clinical factors considered along with radiological findings when making management decisions. Differences in management strategies might exist due to clinical and radiological factors. This study aims at finding possible associations between clinical and radiological observations. Methods: A prospective cross-sectional study of 52 patients with primary osteoarthritis of the knee managed conservatively at a tertiary hospital arthroplasty clinic was conducted for three months. English speaking patients with primary OA were identified and included in this study. Pain and functional impairment were assessed using Wong-Baker Faces pain scale, The Knee Society Score (KSS), and Western Ontario and McMaster Osteoarthritis Index (WOMAC). The Body Mass Index (BMI) of all participants was measured. Standard two views plain radiographs were used for radiographic grading of the OA. Anonymized radiographs were presented to two senior consultant orthopaedic surgeons who graded the OA using Kellgren and Lawrence (KL) and Ahlbäck classification systems. The severity of the functional impairment and pain score was then compared to the radiological grading. Results: The average age of our participants was 63 ± 9 years. Their average BMI was 34.9 ± 8.4 kg/m2, median self-reported pain, total WOMAC, and pain WOMAC scores were 8, 60, and 13, respectively. We observed no significant correlation between BMI and pain scores. Inter-rater reliability for KL and Ahlbäck grading was strong. There was no significant correlation between WOMAC scores and the radiological grades. Conclusion: There was no correlation between pain and functional scores, patient factors and radiological severity of OA of the knee.
A composite clinical motor score as a comprehensive and sensitive outcome measure for Parkinson’s disease

Background An unmet need remains for sensitive outcome measures in neuroprotective trials. The study aims to determine whether a composite clinical motor score, combining the Movement Disorders Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) III motor examination score, Purdue Pegboard Test, and Timed Up and Go, provides greater sensitivity in detecting motor change in early disease than the MDS-UPDRS III alone. Methods The Oxford Discovery longitudinal cohort study involves individuals with isolated rapid eye movement sleep behaviour disorder (iRBD) (n=272, confirmed polysomnographically, median follow-up: 1.6 years), idiopathic Parkinson’s disease (PD) (n=909, median follow-up: 3.5 years, baseline: <3.5 years disease duration) and controls (n=316, age-matched and sex-matched, without a first-degree family history of PD). Motor and non-motor assessments were performed at each in-person visit. Results Compared with the MDS-UPDRS III, the composite clinical motor score demonstrated a wider score distribution in iRBD and controls, lower coefficient of variation (37% vs 67%), and higher correlation coefficients with self-reported measures of motor severity (0.65 vs 0.61) and overall health status (−0.40 vs −0.33). Greater score range in mild to moderate PD, higher magnitude of longitudinal change in iRBD and longitudinal score linearity suggest better sensitivity in detecting subtle motor change. The composite clinical motor score was more accurate than the MDS-UPDRS III in predicting clinical outcomes, requiring 64% fewer participants with PD and 51% fewer participants with iRBD in sample size estimations for a hypothetical 18-month placebo-controlled clinical trial. Conclusion The composite clinical motor score may offer greater consistency and sensitivity in detecting change than the MDS-UPDRS III.
The effect of a gap concept on peripheral nerve recovery in modified epineurial neurorrhaphy: An experimental study in rats

Several factors such as surgical approach that only consider topographic anatomy; inadequate fascicular alignment, extraepineurial sprouting in the repair zone; contact of axons with the suture area are the disadvantages of epineurial neurorrhaphy. Accordingly, axonal mismatch, neuroma, and unfavorable nerve recovery become inevitable. Neurotropism is the theory clarifying appropriate matching of the nerve fibers independently without needing surgical approach. The studies comparing the primary nerve repair with the nerve defects bridged in different ways demonstrated better outcomes of nerve recovery in the groups with a nerve gap. In this study, we aimed to demonstrate the effects of the gap concept in primary nerve repair bridged by own epineurium. We hypothesized that this technique will provide better results in terms of peripheral nerve recovery and will significantly eliminate the occurrence of a neuroma, which is quite possible in epineurial neurorrhaphy.
Paraphrase Detection for Thai Textual Documents

The phenomenon of plagiarism in the digital contents is raising in present day and become the huge problem for idea stealing detection. Fortunately, the automatic identification of sentences in textual documents plays an important role fighting to the idea piracy. In this paper, the developed system presents the methodology to deal with the paraphrase detection through Thai academic documents. The suggestion methodologies include LCS and Wu and Palmer in order to investigate alike for sentence pairs.
Whole-genome sequence and methylome profiling of the almond ( dulcis quality control tool for high throughput sequence

26 Almond ( Prunus dulcis [Mill.] D.A. Webb) is an economically important, specialty nut crop 27 grown almost exclusively in the United States. Breeding and improvement efforts worldwide 28 have led to the development of key, productive cultivars, including ‘Nonpareil,’ which is the 29 most widely grown almond cultivar. Thus far, genomic resources for this species have been 30 limited, and a whole-genome assembly for ‘Nonpareil’ is not currently available despite its 31 economic importance and use in almond breeding worldwide. We generated a 615.89X coverage 32 genome sequence using Illumina, PacBio, and optical mapping technologies. Gene prediction 33 revealed 27,487 genes using MinION Oxford nanopore and Illumina RNA sequencing, and 34 genome annotation found that 68% of predicted models are associated with at least one 35 biological function. Further, epigenetic signatures of almond, namely DNA cytosine methylation, 36 have been implicated in a variety of phenotypes including self-compatibility, bud dormancy, and 37 development of non-infectious bud failure. In addition to the genome sequence and annotation, 38 this report also provides the complete methylome of several key almond tissues, including leaf, flower, endocarp, mesocarp, fruit skin, and seed coat. Comparisons between methylation profiles in these tissues revealed differences in genome-wide weighted percent methylation and chromosome-level methylation enrichment. The raw sequencing data are available on NCBI 42 Sequence Read Archive, and the complete genome sequence and annotation files are available on 43 NCBI Genbank. All data can be used without restriction.
DEVELOPMENT OF A HIGH-PERFORMANCE VERTICAL AXIS WIND TURBINE BY A DRIVE PRINCIPLED METHOD AND AN APPLICATION OF WIND-ENERGY COLLECTING STRUCTURE

PRINCIPLED METHOD AND AN APPLICATION OF WIND-ENERGY COLLECTING STRUCTURE 渡邉 康一 1) 大屋 裕二 2) 烏谷 隆 3) Koichi WATANABE, Yuji OHYA,Takashi KARASUDANI 垂直軸型風車は風に対して無指向性であり,発電機などの重量物を地表近くに置くことができるという長 所をもつ. 中でも直線翼のものは加工が簡単で,低コストでの製作が可能である. しかし,発電効率におい ては,一般に水平軸型風車と比較して低い. 研究の分野においても垂直軸型風車は頻繁に取り上げられてい るが,その駆動原理にまで踏み込んで高出力化に取り組んだ報告は少ないようである。 高出力の垂直軸型風車発電システムの開発に関する本研究は,風から有効にエネルギーを取り出す風車の 開発,及び風車周辺の風のエネルギーを効率的に集める方法の発見を一連の研究目的とするものである. こ れらの目的に対し,ブレード周りの流れ場を解析して直線翼垂直軸型風車の駆動原理の解明に取組み,出力 増加を得るために必要な条件を明らかにした. また,大屋ら 1) が開発した集風加速装置を垂直軸型風車に設 置し,大幅な出力増加を達成した。 本集風加速装置付き垂直軸型風車の開発は,まずは垂直軸型風車および 集風加速装置に関する一般的な知見を得ることを目指しており,次の段階として高出力な垂直軸型風車の開 発,および周囲構造物の最適形状設計を実施することにしている。 A study of drive principle of Vertical Axis Wind Turbine(VAWT) is made. Moreover, to obtain higher performance of VAWT, an application of wind collecting structure is investigated. The wind collecting structure consists of inlet, diffuser and brim, and it can collect and accelerate the approaching wind at the throat. The wind tunnel experiment and the numerical calculation are made. The numerical calculation is Direct Numerical Simulation (DNS) for both defining the mechanism of VAWT and design of the wind collecting structure. As a result, we conclude as follows. : Torque is generated when the turbine blades move upstream side. Power output of VAWT is proportional to the cube of the wind speed in the same manner of Horizontal Axis Wind Turbine (HAWT). So, an application of a wind collecting diffuser causes large increase og the performance of VAWT. aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa 2. 風洞実験と数値解析の方法 2.1 風洞実験法
Colony of robots: New Challenge Workshop invited key lecture

The evolution on Robotics has in a cross way of application. For one side is the applications to manufacturing, other one is application to medicine, another one in space exploration and it is starting home applications. It is very popular to have contest of robots for students, motivating very well to student, supported by universities, achieving good image for the institutions. One way for mobile robots is Nomad, a nice application for having new knowledge in the space, but the inversion it is very expense and complex. If it has problem or fail, all the work will stop. Instead of that, if you use a community of robots, working like a society of insect, it is possible to have simpler mobile robots to have specific tasks, less expensive, more reliable to reach the same aims. In this presentation is focusing in colony of robots. This implies to merge several disciplines based on models of communities, to have control of a society of robots working together in a collaborative and cooperative way in non structured environments. Keywords: Multi-robots, Colony of robots, Multiagents Systems
A trophic niche shift in a South American migrant: Stable nitrogen isotope signatures in feathers of Fork-tailed Flycatchers (Tyrannus savana)

ABSTRACT Understanding how diet and life history strategies interact is important for exploring constraints of available nutrition on energetically expensive life history events in wild animals (i.e., reproduction, annual migration, molt). Previous research on migratory birds breeding in the Northern Hemisphere has demonstrated trophic niche shifts from invertebrates to fruit in order to fuel spring migration. We examined whether a trophic niche shift occurred in a Neotropical austral migrant, the Fork-tailed Flycatcher (Tyrannus savana savana), prior to spring migration by measuring stable nitrogen isotopes in feathers. We found that the austral migrant subspecies T. s. savana did appear to shift in diet from a higher to a lower trophic level (consistent in pattern with a shift from a higher to a lower ratio of invertebrates to fruit) but the shift occurred earlier than expected if it was preparation for migration. A sympatric sedentary subspecies occupying the same habitat (T. s. monachus) appeared to forage only at the lower trophic level during its annual molt and showed no evidence of a trophic niche shift; however, the molt of the 2 subspecies occurs at slightly different times of year. The timing of the trophic niche shift leads us to conclude that a higher trophic level diet early in molt is not related to preparation for spring migration but that it may be related to seasonal changes in food availability as the wet season concludes. A remaining challenge for understanding the ecological consequences of trophic niche shifts is to find ways to empirically measure trade-offs between different diets across energetically expensive life history events and compare these between taxa with differing life history strategies.
Assessing Early-Stage CO2utilization Technologies-Comparing Apples and Oranges?

CO2 utilization involves many disciplines—fields as different as apples and oranges. Technology assessment is a common tool for evaluation. This article analyses its current state in CO2 utilization. First, the steps of chemical product development are matched with technology readiness levels (TRLs) for classification. Second, relevant literature is selected, and assessment methods and indicators are examined. The analysis shows that standardization in CO2 utilization technology assessment is low. Current research addresses some but not all assessment fields and tends to use a large range of indicators, making comparison difficult. Overall standard methods are needed as they could facilitate technology comparison and provide a better understanding of trade-offs. Future assessments should be extended to the definition of a standard set of assessment indicators, the further adoption of social impact assessment for all TRLs, and the inclusion of environmental impact assessment at early stages.
Non-IID spatio-temporal prediction in smart cities

Non-IID spatio-temporal prediction research points toward emerging directions and fundamental solutions to address various complexities from the perspective of both data couplings and heterogeneity. Delving into the non-IID challenge and opportunity of spatio-temporal prediction in smart cities, this article also addresses current solutions to bring some inspiration to future researchers.
Assistive Communication Technologies and Stigma: How Perceived Visibility of Cochlear Implants Affects Self-Stigma and Social Interaction Anxiety

Assistive technologies promise improved functionality for people with disabilities, but their use and adoption are complicated. Previous research has identified several reasons why people with disabilities choose to abandon their assistive technologies. However, less is known about the adoption of assistive technologies that are permanent and user perceptions of these technologies. This study builds upon existing assistive technology, disability, identity, and stigma literature by examining the role of perceptions of cochlear implants, an assistive technology that permanently renders an invisible disability visible, among the single-sided deaf community. Analysis of survey data from 332 single-sided deaf individuals with cochlear implants all over the world revealed that the perceived visibility of assistive technology is positively associated with self-stigma and social interaction anxiety. Results from this study highlight the centrality of sociotechnical perceptions of assistive technologies to the experience of stigma, rather than the objective characteristics and features of technology, and problematize the existing dichotomous approach (visible v. invisible) to understanding assistive technologies. This study also illuminates the importance of studying assistive technologies on an intragroup level as well as focusing on how specific stigmatized niche communities may perceive and use their assistive technologies.
Social Debunking of Misinformation on WhatsApp: The Case for Strong and In-group Ties

In this paper, we argue that WhatsApp can play an important role in correcting misinformation. We show how specific WhatsApp affordances (flexibility in format and audience selection) and existing social capital (prevalence of strong ties; homophily in political groups) can be leveraged to maximize the re-sharing of debunking messages, such as those accessed by WhatsApp users via ChatBots and Tip-Lines. Debunking messages received in the format of audio files generated more interest and were more effective in correcting beliefs than text- or image-based messages. In addition, we found clear evidence that users re-share debunks at higher rates when they received them from people close to them (strong ties), from individuals who generally agree with them politically (in-group members), or when both conditions are met. We suggest that WhatsApp leverages our findings to maximize the re-share of those fact-checks that are already circulating on the platform by using the existing social capital in the network, unlocking the potential for such debunks to reach a larger audience on WhatsApp.
Material insecurity predicts greater commitment to moralistic and less commitment to local deities: a cross-cultural investigation

ABSTRACT The existential security hypothesis predicts that in the absence of more successful secular institutions, people will be attracted to religion when they are materially insecure. Most assessments, however, employ data sampled at a state-level with a focus on world religions. Using individual-level data collected in societies of varied community sizes with diverse religious traditions including animism, shamanism, polytheism, and monotheism, we conducted a systematic cross-cultural test (N = 1820; 14 societies) of the relationship between material insecurity (indexed by food insecurity) and religious commitment (indexed by both beliefs and practices). Moreover, we examined the relationship between material security and individuals’ commitment to two types of deities (moralistic and local), thus providing the first simultaneous test of the existential security hypothesis across co-existing traditions. Our results indicate that while material insecurity is associated with greater commitment to moralistic deities, it predicts less commitment to local deity traditions.
Early nutrition programming with Astragalus membranaceus polysaccharide: its effect on growth, carcasses, immunity, antioxidants, lipid profile and liver and kidney functions in broiler chickens

Abstract This study aimed to determine the influence of in ovo injection of Astragalus membranaceus polysaccharide on growth, feed consumption, feed conversion ratio, carcasses, hematology, and blood metabolites in Cobb 500 chicks. At the 7th day of incubation, a total of 250 eggs were randomly divided into five groups with 5 replications of 10 eggs of each: negative control (normal eggs), positive control (0.5 mL saline), 1.5 mg Astragalus membranaceus, 3.0 mg Astragalus membranaceus, and 4.5 mg in ovo Astragalus membranaceus injection. Live body weight and gain were not significantly (linear and quadratic) affected by in ovo injection of Astragalus membranaceus. Kidney and liver functions were influenced by in ovo injection of Astragalus membranaceus polysaccharides in broiler chickens. Antioxidant enzymes were quadratically increased with Astragalus membranaceus polysaccharides, and the highest values achieved with 4.5 mg. The MDA concentration was linearly and quadratically decreased with in ovo injection of Astragalus membranaceus polysaccharides when compared to negative control. The highest values of IgG and IgM were achieved with 1.5 mg Astragalus membranaceus polysaccharides when compared to all other groups. In conclusion, our results indicate that in ovo injection of Astragalus membranaceus polysaccharides 1.5–4.5 mg in broiler eggs significantly improved serum ALT, AST, AP, creatinine enzymes, antioxidant activity, and immune function.
Combining Goal modelling with Business Process modelling Two Decades of Experience with the User Requirements Notation Standard

Goal modelling aims to capture stakeholder and system goals, together with social, intentional, and structural relationships, in a way that supports trade-off analysis and decision making. Goal models and business process models provide complementary and synergetic views of a system, which lead to a more complete understanding of what exists and a better description of what needs to be designed than with only one of these views. The User Requirements Notation (URN), standardized in 2008 by the International Telecommunication Union (ITU-T) with improved versions in 2012 and 2018, combines goal modelling with process modelling, while providing graphical and textual syntaxes for both views. URN helps modellers exploit the value of social modelling in the context of process design and improvement. In this paper, we report on nearly two decades of combined goal/process modelling with URN in different areas – based on coarse-grained statistics from a literature review and the authors’ personal experiences with URN. In particular, beyond the telecommunication services for which URN was created, we highlight applications to goal/process alignments, regulatory compliance and intelligence, process adaptation and improvement, value co-creation and service systems, and goal-oriented process mining, as well as several advanced modelling techniques. An overview of the tool-supported analyses (for satisfaction, alignment, compliance, and others) and model creation mechanisms (composition, aspects, slicing, adaptation, reuse, and others) is also provided. The last part of this paper focuses on important challenges and exciting opportunities for future research, especially in the areas of data-driven applications (e.g, AI/machine learning), socio-cyber-physical systems, and usable automation