Miracle-dz/UniFAR-FTUs huggingface dataset:
Evidence for a Bene fi cial Role of Basophils in Acquired Immunity to the Feeding of Ixodid Ticks

opyright a 2016 American Society for Inve ublished by Elsevier Inc. All rights reserved ttp://dx.doi. org/10.1016/j.ajpath. 2015.07. 025 Mast cells and IgE are so inextricably linked to the pathology of allergic disorders, including fatal anaphylaxis, that it can be difficult to think of them in other contexts. Surely, we do not have mast cells and IgE so that we can eat a peanut and die! It is thought that mast cells and IgE and basophils (circulating granulocytes, whose functions partially overlap with those of mast cells) can contribute to host defense as components of adaptive T helper cell type 2 immune responses to helminths, ticks, and certain other parasites. Accordingly, it was suggested that allergies are misdirected type 2 immune responses in which IgE antibodies are produced against any of a broad variety of apparently harmless antigens. However, components of animal venoms also can sensitize individuals to develop severe IgEassociated allergic reactions, including fatal anaphylaxis, on subsequent venom exposure. Here, I describe evidence that mast cells can enhance innate host resistance to reptile or arthropod venoms during responses to an initial exposure to such venoms and that acquired type 2 immune responses, IgE antibodies, the high-affinity IgE receptor FcεRI, and mast cells can contribute toward acquired resistance in mice to the lethal effects of honeybee or Russell’s viper venom. These findings support the hypothesis that mast cells and IgE can help protect the host against noxious substances. (Am J Pathol 2016, 186: 212e224; http://dx.doi.org/10.1016/j.ajpath.2015.07.025)
and Eric Beauregard Offenders ' Lifestyles Routine Activities and Time Use : A Latent Profile Approach to Sexual

The routine activities of a sample of 147 incarcerated sexual offenders were studied. During interviews conducted between 1994 and 2000 in a province of Canada, data were collected on the participants’ time involvement in a variety of activities in the weeks preceding their index sexual offense(s). Using latent profile analysis, a typology of lifestyles of sexual offenders was created. Five distinct profiles were identified. The inactive loner was characterized by little time involvement with their romantic partners and social activities. The social traveler spent the highest time driving and reported the highest number of friends. The single walker reported the highest amount of time walking around. The partyers’ lifestyle was centered around alcohol and drugs. Finally, offenders from the familial homebody profile spent most of their time at home. Differences between profiles were investigated with regard to characteristics of index sexual offense.
Title : Evaluation of Primary Mediastinal Large B cell Lymphoma by Flow Cytometry Short title for running head : Flow cytometry in PMLBCL

BACKGROUND: Primary mediastinal large B cell lymphoma (PMLBCL) is a B cell non-Hodgkin lymphoma (B-NHL) that shows morphologic, immunophenotypic, and genetic similarities to classical Hodgkin lymphoma (CHL). We evaluated the neoplastic and reactive infiltrate of PMLBCL by flow cytometry (FC). METHODS: 24 cases of PMLBCL were retrospectively characterized using FC combinations for B-NHL, T-NHL, and CHL. RESULTS: The CHL assay identified the neoplastic population (NP) in all cases, while the B-NHL assay identified the NP in 18 of 24 cases. In 4 cases, the neoplastic population was retrospectively identified in the B-NHL tube, given the CHL tube-derived immunophenotype. Neoplastic cells of PMLBCL displayed a B cell immunophenotype (CD19/CD20+), with CD40 consistently and brightly expressed. Most cases lacked immunoglobulin light chains, CD10, and CD15; CD30 was frequently expressed. All cases showed expression of CD71 and CD95. The reactive infiltrate in PMLBCL showed increases in T cells relative to reactive tissues. Lower CD4/CD8 ratios in PMLBCL relative to CHL and reactive tissues were also observed. Although not seen as commonly as with CHL, 41% of cases showed a reactive CD3/CD4/CD7 bright /CD45 bright + T cell population. Reactive populations seen in PMLBCL were similar to that seen in diffuse large B cell lymphoma, not otherwise specified. This article is protected by copyright. All rights reserved. CONCLUSIONS: FC can detect the NP of PMLBCL and a FC assay for CHL performed better than a B-NHL assay in this regard. The neoplastic cells showed a B cell immunophenotype with over-expression of CD40. The reactive infiltrate in PMLBCL shows unique features including a prominent CD8+ T cell
Optimum quantum dot size for highly efficient fluorescence bioimaging

Semiconductor quantum dots of few nanometers have demonstrated a great potential for bioimaging. The size determines the emitted color, but it is also expected to play an important role in the image brightness. In this work, the size dependence of the fluorescence quantum yield of the highly thermal sensitive CdTe quantum dots has been systematically investigated by thermal lens spectroscopy. It has been found that an optimum quantum yield is reached for 3.8-nm quantum dots. The presence of this optimum size has been corroborated in both one-photon excited fluorescence experiments and two-photon fluorescence microscopy of dot-incubated cancer cells. Combination of quantum yield and fluorescence decay time measurements supports that the existence of this optimum size emerges from the interplay between the frequency-dependent radiative emission rate and the size-dependent coupling strength between bulk excitons and surface trapping states.
Methods Aspartate aminotransferase , alanine aminotransferase , total bilirubin , and direct bilirubin in the serum Collected blood

This was a randomized, parallel, and placebo-controlled study. Forty subjects were divided into a test group and a placebo group. The study was focused on the potential effects of a mixture of Schisandra fruit extract and sesamin (hereinafter called ‘SCH’) in the subjects with borderline high levels (40–60 U/L) of alanine aminotransferase (ALT) or aspartate aminotransferase (AST). Twenty subjects taking SCH (four tablets per day) and 20 subjects taking a placebo (four tablets per day) were studied. The effects of SCH on ALT, AST, total bilirubin, direct bilirubin, free radical levels, total antioxidant status, glutathione peroxidase, glutathione reductase, and the lag time for low-density lipoprotein oxidation were determined. The total test period was 5months. Intervention of SCH clearly reduced the levels of ALT and AST, but it made no change in the total bilirubin and direct bilirubin. Intake of SCH also greatly increased the antioxidant capacity and decreased the values of thiobarbituric acid reactive substances, total free radicals, and superoxide anion radicals in the plasma. The activities of glutathione peroxidase and reductase in the erythrocytes were significantly increased. In addition, the lag time for low-density lipoprotein oxidation, an inflammatory marker, was evidently increased. Fatty liver was found to have been significantly improved in this study. SCH proved to have the effects of antioxidation and improving liver function. Copyright © 2012 John Wiley & Sons, Ltd.
Modelling multivariate disease rates with a latent structure mixture model

There has been considerable recent interest in multivariate modelling of the geographical distribution of morbidity or mortality rates for potentially related diseases. The motivations for this include investigation of similarities or dissimilarities in the risk distribution for the different diseases, as well as ‘borrowing strength’ across disease rates to shrink the uncertainty in geographical risk assessment for any particular disease. A number of approaches to such multivariate modelling have been suggested and this paper proposes an extension to these which may provide a richer range of dependency structures than those encompassed so far. We develop a model which incorporates a discrete mixture of latent structures and argue that this provides potential to represent an enhanced range of correlation structures between diseases at the same time as implicitly allowing for less restrictive spatial correlation structures between geographical units. We compare and contrast our approach to other commonly used multivariate disease models and demonstrate comparative results using data taken from cancer registries on four carcinomas in some 300 geographical units in England, Scotland and Wales.
Analysis of the Relationship between Human Capital Development and Economic Growth in Nigeria

This research aimed at examining the relationship between human capital development and economic growth in Nigeria. We made use of co-integration techniques and The vector error correction model (VECM). It was observed that there is significant long-run relationship between human capital development and economic growth in Nigeria. This is confirmed by the Johansen co-integration. Also the result of vector error correction model (VECM) indicates that 1% increase in the government expenditure on education (TEDU), on the average, led to 23.8% increase in GDP while 1% increase in the government expenditure on health (THEA) caused 37.6% decrease in GDP. The two variables, as human capital development factor, were found to have significant effect on economic growth. However, government expenditure on education has positive relationship with GDP. This implies that increase in expenditure on education contributes positively to the growth of the economy. The policy implications are in three directions: To retain the continuous long run relationship with GDP and human capital development, effort should be made to harmonize the activities in the health and education sector with much attention on funding; Government expenditure on education was found to have positive effect on the economy. In the light of this, government should try as well to meet up with world standard benchmark on education expenditure in the annual budget. In so doing, this will improve on the economy and Government expenditure on health was found to have negative effect on the economy. Therefore, effort should be made by government to address the agitations by the health workers which always make them to resort to frequent strike actions. If these worrying issues are looked into, perhaps the instability experienced in the health sector would be addressed. Efforts should be made to equip our health sector so that capital flight in the name of foreign medical treatment is reduced. Keywords: Human Capital development, Government Expenditure on Education, Government Expenditure on Health, Nigeria.
University regulation and university–industry interaction: a performance analysis of Italian academic departments

In a context characterized by public spending reviews and research funding shortages, governments in several countries are putting pressure on universities to increase their applied research activity, intensify their interaction with industry, and attract funding from the nonacademic domain. The economic literature provides rich evidence on the convergence between institutional factors and individual-level characteristics that are influencing university involvement in knowledge transfer activities. The aim of this article is to investigate the impact of universities’ regulation of knowledge transfer activities on the institutional capability to raise funding from research contracts and consultancies. Based on extensive department-level data on university funding, we address the characteristics of institutional knowledge transfer practices and investigate how these activities influence the intensity of funding to Italian universities.
Bachelorthesis „ Internet therapy for anxiety disorders “ A critical review of its effectiveness

Anxiety disorders are worldwide the most prevalent of the psychiatric disorders as about every sixth person will acquire one at some point in life. They bring with them a high degree of suffering for the patient and huge economic costs to society. In order to make therapy available and attractive to a much greater number of patients and in order to reduce costs ADAPT is developing an internet therapy for anxiety disorders. Down to the present day little is known about its effectiveness, therefore this paper will investigate whether internet therapy is a viable alternative or supplement to usual face-to-face therapy. A search was conducted for meta-analyses and other reviews on the topic and 13 studies testing internet therapy for anxiety disorders and other medical problems were evaluated. Results show that internet therapy is as effective as usual face-to-face therapy in reducing anxiety symptomatology, as long as therapist contact is available to patients. The target group was found to consist mainly of well-educated, working women. Internet interventions can thus be a cost-effective alternative or supplement to usual treatment; although a great deal of further research has yet to be conducted so as to be able to rule out possible disadvantages and to be able to apply internet therapies on other health problems as well.
Toxicological evaluation of the petroleum ether extract of Leonurus japonicus on liver, kidney and testis in rats

The sub-acute toxicity of the petroleum ether extract of Leonurus japonicus (PELJ) in rats was investigated, and as a comparison, that of the boiled decoction of L. japonicus (DLJ) was also investigated. In rats which received a once-daily administration of PELJ and DLJ at the dose of 60 g/kg by intragastric gavage for 15 days, there was a significant decrease in the body weight gain and an increase in the relative weight of testis and levels of serum blood urea nitrogen (BUN) as well as in the amount of creatinine, glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), alkaline phosphatase (ALP), lactic dehydrogenase (LDH) and γ-glutamyltransferase (GGT), urinary protein concentration and urinary NAG. Also, histopathological changes of liver, kidney and testis were observed. The altered levels of body weight, relative organ weight and the biochemical parameters except for urinary protein concentration tended to be restored, and the histopathological changes of liver, kidney and testis were ameliorated in rats that had been withdrawn from the treatment for another 15 days recovery period. PELJ and DLJ exhibited similar toxic effects and the toxic effects of DLJ were lower than those of PELJ. The results demonstrated that PELJ and DLJ at the given dose produced apparent toxicity in rats and that permitting rats to recover for 15 days resulted in partial recovery. Besides, the compositions of PELJ were analyzed by GC–MS. The major components identified in PELJ were 17b-hydroxy-1a, 17-dimethyl-5a-androstan-3-one (21.47%), stigmast-5-en-3-ol (11.86%), E-phytol (9.94%), and caryophyllene oxide (8.69%). Key words: Leonurus japonicus, petroleum ether extract, GC-MS, toxicity, liver, kidney, testis.
Title Ensemble singular vectors and their use as additive inflation inEnKF

Given an ensemble of forecasts, it is possible to determine the leading ensemble singular vector (ESV), that is, the linear combination of the forecasts that, given the choice of the perturbation norm and forecast interval, will maximise the growth of the perturbations. Because the ESV indicates the directions of the fastest growing forecast errors, we explore the potential of applying the leading ESVs in ensemble Kalman filter (EnKF) for correcting fast-growing errors. The ESVs are derived based on a quasi-geostrophic multi-level channel model, and data assimilation experiments are carried out under framework of the local ensemble transform Kalman filter. We confirm that even during the early spin-up starting with random initial conditions, the final ESVs of the first analysis with a 12-h window are strongly related to the background errors. Since initial ensemble singular vectors (IESVs) grow much faster than Lyapunov Vectors (LVs), and the final ensemble singular vectors (FESVs) are close to convergence to leading LVs, perturbations based on leading IESVs grow faster than those based on FESVs, and are therefore preferable as additive inflation. The IESVs are applied in the EnKF framework for constructing flow-dependent additive perturbations to inflate the analysis ensemble. Compared with using random perturbations as additive inflation, a positive impact from using ESVs is found especially in areas with large growing errors. When an EnKF is ‘cold-started’ from random perturbations and poor initial condition, results indicate that using the ESVs as additive inflation has the advantage of correcting large errors so that the spin-up of the EnKF can be accelerated.
Prostaglandins, Leukotrienes and Essential Fatty Acids

Previous studies have shown that Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) exhibit triacylglycerol (TAG) lowering effect in vitro and in vivo by down-regulating the Sterol Regulating Element Binding Protein (SREBP-1c) and reducing the expression levels of lipogenic genes. However, there is no evidence on the effect of Docosapentaenoic Acid (DPA) on SREBP-1c expression levels. DPA is a long chain n-3 fatty acid present in our diet through fish, red meat and milk of ruminant animals. Therefore, this study aimed to elucidate the effect of DPA on liver fatty acid synthesis in an in vitro model using rat liver cells. Our results suggested that DPA incubation (50 mM) for 48 h (like EPA and DHA) caused a significant decrease in the mRNA expression levels of SREBP-1c, 3-Hydroxy-3Methyl-Glutaryl-Coenzyme A reductase (HMG-CoA reductase), Acetyl Coenzyme A Carboxylase (ACC-1) and Fatty Acid Synthase (FASn) compared with Oleic Acid (OA) and also a decrease in the protein levels of SREBP-1 and ACC-1. A time-course fatty acid analysis showed that DPA and EPA are interconvertable in the cells; however, after 8 h of incubation with DPA, the cell phospholipids contained mainly DPA. The gene expression profiling of the lipogenic genes repeated at 8 h confirmed that the inhibitory effect of DPA on mRNA expression levels of the lipogenic genes was most likely due to DPA itself and not due to its conversion into EPA. & 2011 Elsevier Ltd. All rights reserved.
Aalborg Universitet Control Structures for Smart Grid Balancing

This work addresses the problem of maintaining the balance between consumption and production in the electricity grid when volatile resources, such as wind and sun, account for a large percentage of the power generation. We present control structures for Smart Grid balancing services on three different levels: portfolio, larger scale individual power units, and aggregations of small power units. Our focus is on illustrating the connection between coordination and control algorithms.
Dhruv Sareen Repeat Expansion C 9 ORF 72 with a Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients

, 208ra149 (2013); 5 Sci Transl Med et al. Dhruv Sareen Repeat Expansion C9ORF72 with a Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients Editor's Summary repeat expansion. C9ORF72 may be a strategy for treating ALS patients with the contributes to the death of motor neurons in ALS, and suggest that antisense oligonucleotides targeting this transcript these RNA foci. These findings support the idea that the buildup of ''toxic'' RNA containing the GGGGCC repeat RNA transcript sequence (''antisense oligonucleotides'') suppressed the formation of C9ORF72 complementary to the ALS patients and disrupted the function of these cells. Furthermore, they observed that oligonucleotides ALS patients. They found that large pieces of RNA containing the expanded GGGGCC repeat built up in neurons from skin cells from patients with the disease and converted them into motor neurons in a culture dish, the cells that die in causes cell degeneration. They took C9ORF72 set out to understand how the expansion of the GGGGCC repeat in . et al was recently identified as the most common genetic cause of ALS. In their new study, Sareen C9ORF72 called breathe, and no effective therapies currently exist. The expansion of a repeated DNA element (GGGGCC) in a gene cells in the nervous system that control the musculature. Patients slowly become paralyzed and lose the ability to Amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease) is a uniformly fatal disease caused by the death of Clearing Toxic RNA in ALS
Organizational Citizenship Behaviors In Small And Medium Enterprises In The Context Of Leadership Behavior

The purpose of this paper is to find out “What is the effect of different types of leadership behavior on organizational citizenship behavior shown by employees within small and medium enterprises” Past literature research in the field of small and medium enterprises shows that SMEs research is related to the human research management. Most of past research about leadership behavior has been done on large organization. A little level of research about leadership behavior has been done on small and medium level enterprises. The question arises that leadership behavior on large organizational are same as in small and medium enterprises or different. Due to the personal and close relationship, short communication, informality and hierarchy structure cause the leader to behave in different way within small and medium size enterprises. These factors have a different effect by the leader toward their employees which is helpful to motivate the employees to perform beyond the requirement. It is expected that transformational leaders have a strong and positive effect on organizational citizenship behavior shown by employees as transformational leader encourage the employees in order to perform beyond the requirement. It is also expected that contingent rewarding leadership behavior have positive effect on employees to show organizational citizenship behavior because after getting reward upon their performance, they feel more motivated to perform more than the requirement. Management by exception has two categories which are active behavior and passive behavior. It is expected that management by exception active have a positive effect because he works in an active way. He can find mistakes, failure and errors before its effect and try to solve these mistakes, failure and error as soon as possible. It is expected that management by exception passive have negative behavior because passive leader waiting for mistakes, failures and errors. Trust is also an important factor between leadership behavior and employees. It is accepted that some certain degree of trust motive the employees to show organizational citizenship behavior. Next to this it also help the employees to perform beyond the requirement. The data were collected from the past researcher in order to find out results. Past research shows that when firm face serious problems or mistake, errors or any failure leader should be there in order to solve problems, mistakes, failure and error. Leader in small and medium enterprise are required to give the authority to the employees in order to solve problems themselves. Leader should also create certain level of trust which is encouraging the employees to show organizational citizenship behavior. Most of leader in small and medium enterprises do not know about their effect on employees. This research is based on past research. This research make aware the leader, how to influence the employees to show organizational citizenship behavior.
Klebsiella clinical isolates as serotype O 12 Antiserum against Raoultella terrigena ATCC 33257 identifies a large number of Raoultella and

http://ini.sagepub. com/content/16/6/366 The online version of this article can be found at: DOI: 10.1177/1753425909350057 2010 16: 366 originally published online 6 January 2010 Innate Immunity Katja Mertens, Sven Müller-Loennies, Petra Stengel, Rainer Podschun, Dennis S. Hansen and Uwe Mamat Klebsiella clinical isolates as serotype O12 Antiserum against Raoultella terrigena ATCC 33257 identifies a large number of Raoultella and