escriptive epidemiology of 13 , 038 newly diagnosed and istologically confirmed meningiomas in France : 2006 – 2010 pidémiologie descriptive de 13 038 cas de méningiomes opérés en France entre 006 et 2010

Purpose. – This work describes the clinical epidemiology and pathology for patients undergoing surgery for newly diagnosed meningiomas in France between 2006 and 2010. Methods. – The methodology is based on a multidisciplinary national network previously established by the French Brain Tumor DataBase (FBTDB) (in French: Recensement national histologique des tumeurs primitives du système nerveux central [RnhTPSNC]), and the active participation of the scientific societies Please cite this article in press as: Zouaoui S, et al. Descriptive epidemiology of 13,038 newly diagnosed and histologically confirmed meningiomas in France: 2006–2010. Neurochirurgie (2015), http://dx.doi. org/10.1016/j.neuchi. 2014.11. 013 eywords: atabase eningioma euro-epidemiology euro-oncology europathology eurosurgery involved in neuro-oncology in France. Results. – From 2006 to 2010, 13,038 incident cases of meningioma with histological validation were identified and analyzed (9769 women, 3269 men, resection 98.2%, cryopreservation 20.5%). For each histological subtype of meningioma (meningothelial, fibrous, transitional, psammomatous, angiomatous, rare variety, microcystic, secretory, lymphoplasmacyte-rich, clear-cell, chordoid, rhabdoid, metaplastic, atypical, papillary, anaplastic and not otherwise specified), number of cases, sex, median age, cryopreservation and surgery were reported. Among the various histological subtypes, atypical meningioma (grade II) slightly, but significantly, increased after 2007. Headache, sensory-motor impairments and seizures ∗ Corresponding author. Department of neurosurgery, Gui-de-Chauliac hospital, CHU Montpellier, 34295 Montpellier cedex 5, France. E-mail address: l-bauchet@chu-montpellier.fr (L. Bauchet). 1 Sonia Zouaoui and Amélie Darlix equally contributed to the study. 2 Collaborators: Abbey Toby A, Adam C, Adle-Biassette H, Adreux, Albagnac V, Algros MP, Amat C, Ansart F, Arbez-Gindre F, Arbion F, Arrivets P, Aubriot-Lorton MH, Auvigne , Averous G, Pinel-briquel N, Badsi A, Baglin AC, Baldet P, Barbey C, Bazille C, Bedgedjian I, Bedossa P, Benabidallah S, Benali A, Bergemer-Fouquet AM, Bergouignan MA, ernier M, Bertocchi C, Beuvon F, Billotet C, Blechet C, Bondoin L, Bonneau C, Bonyhay G, Bordier, Borrelly C, Bost-Bezeaud F, Boudjadi S, Bouvier C, Brambilla E, Branquet D, ressenot A, Broche C, Brouchet A, Brousse N, Brousset P, Bruniau A, Burel-Vandenbos F, Camparo P, Cahn V, Calvet P, Camo J, Camparo P, Carbonnelle-Puscian A, Carloz E, assagnau E, Cathelineau D, Caulet S, Caveriviere P, Cazals-Hatem D, Chapon F, Charlotte F, Taranger-Charpin C, Chatelain D, Chenard MP, Chretien F, Christov C, Clairotte , Cohen C, Colombat M, Conan V, Conan-Charlet V, Cormier B, Costa K, Costes V, Costes-Charlet N, Coulon A, Couvelard A, Cremades, Croue A, Cruel T, Danjoux M, Darrasse , Daumas-Duport C, Degano-Valmarx S, Delage-Corre M, Delattre C, Delisle MB, Delsol M, Denoux Y, Deschamps L, Desrousseaux M, Diebold MD, Donsbeck AV, Dosda A, reux N, Dubost G, Duga I, Dujardin F, Dumollard JM, Durand L, Duval H, Eimer S, Etchandy MP, Eyremandi RP, Fabre B, Fallet C, Felce-Dachez M, Felix S, Fernandez C, Fetissof , Feutry C, Fornes P, Figarella-Branger D, Figuccio M, Fornes P, Fouet, Fregeville M, Fromont G, Gaillard F, Gallois S, Gaspard C, Gay G, Gonguet AM, Gontier MF, Gonzalez, http://dx.doi. org/10.1016/j.neuchi. 2014.11. 013 028-3770/© 2015 Elsevier Masson SAS. All rights reserved. ARTICLE IN PRESS G Model NEUCHI-709; No. of Pages 7 2 S. Zouaoui et al. / Neurochirurgie xxx (2015) xxx–xxx were the most frequent clinical symptoms. Time between the first clinical symptom and surgery ranged from 0 to 314 months, and was < 3 months in 37% of cases. At the time of surgery, 9% of patients were asymptomatic. Discussion/conclusion. – Given the number of meningiomas not histologically-validated, we can estimate that the gross incidence rate for meningiomas operated in France is about 4.2 per 100,000 person/year. To our knowledge, this work is the most important study evaluating the different subtypes of meningiomas and it validates the relevance of histological databases for central nervous system tumors. © 2015 Elsevier Masson SAS. All rights reserved.