Miracle-dz/UniFAR-FTUs huggingface dataset:
AN INSILICO STUDY: CHARACTERIZATION OF WD-REPEAT PROTEIN FAMILY IN DIFFERENT SPECIES OF MOSQUITOS

In the present investigation, the WD-repeat (WDR) proteins comprise an astonishingly diverse superfamily of regulatory proteins. To date, genome-wide characterization of this family has only been conducted in mosquito and little is known about WDR genes in mosquito ( Aedes , Anopheles and Culex ). This study identified 15 mosquito WDR genes in the latest genome and the WDR family contained a smaller number of identified genes compared to different species of mosquitoes. The WDR proteins were identified and classified in to different subfamilies based on their distinct domain organizations. Although many characteristics of the protein family are similar to those species, several features are quite distinct. Our result of Insilco analysis indicated the existence of well-conserved subfamilies. Moreover, comparative genomic analysis showed that the gene structures of the WDR protein were highly conserved across some different lineage species. Through functional divergence analysis, a substantial divergence was found between WDR protein subfamilies.
Point Cloud Edge Detection and Template Matching with 1D Gradient Descent for Wall Pose Estimation

Mobile manipulation in unstructured construction environments involves a range of complex robotic problems. We address a perception requirement for autonomous brick placement; estimating the pose of a partially built wall to facilitate the placement of the subsequent brick. Our method uses RGB-D data to extract the surface edge points of the wall and classify them as horizontally or vertically aligned. The contribution of this paper encompasses a wall template that encapsulates its surface edge features and a novel 1D gradient descent template matching algorithm for pose estimation. We apply our method in mobile manipulator brick placement, demonstrating its robotic applications. Evaluation methods prove the eﬃcacy of the proposed framework, both quantitatively and qualitatively and using both simulated and real data.
Indoor Positioning and Navigation System for Interior Design Augmented Reality

—The problem of indoor localization and navigation has become increasingly important for a range of different applications. One of these applications is interior design augmented reality. Due to the inability of the global positioning system (GPS) to navigate indoors, and the lack of any global indoor localization scheme, research has turned to develop several approaches and solutions to indoor localization. Accuracy of these techniques ranges from few centimeters to few meters depending on the technology used. High accuracy is achieved through special hardware equipment. For interior design applications, users are interested in getting high accuracy in certain positions depending on the design layout. It is also desirable to use market tablets and mobile phones rather than special hardware for such applications. In this paper, a hybrid WiFi ﬁngerprinting - sensor fusion scheme is proposed to achieve accurate indoor positioning and navigation using Android tablets. Moreover, an algorithm has been developed to determine the WiFi Access Points (APs) positions given the apartment layout. Results show high accuracy for both the positioning and navigation parts.
Examining Free Trade Agreements’ Effects on Indonesian Export Performance: A Panel Data Analysis Using Fixed and Random Effect

The purpose of this study is to evaluate the effect of Free Trade Agreement of Indonesia on its export performance using panel data. Panel data in this study consists of relevant variables from 50 Indonesian trading partner countries between 2007-2017. The export performance based on value of two leading commodities of Indonesia and other two prioritized commodities will be treated as dependent variable. While as the independent variable this study will employ dummy Free Trade Agreement (FTA), and several variables which are observed from country partner such as Gross Domestic Product (GDP), Population, Logistic Performance Index (LPI), average tariff and the exchange rate of country partner to Indonesian Rupiah. This study conducted the multiple regression by using fixed and random effect model to analyze the panel data. Importantly, Hausman Test conducted to elect the best fitted estimation between Fixed and Random Effect regression model. Hence, this study will cast a light on how significant Free Trade Agreement affects Indonesian export performance based on the leading commodities by taking into account factors that affect trade in general. Moreover, the fitted regression results yield significant coefficient of Free Trade Agreement in improving manufactures, low-technology, and high-technology commodities export value. Whereas it does not give significant effect in food commodities. Equally important, this study conclude that diverse variables affect export value differently based on the products characteristic, consumer preference, and market condition.
Male-Speciﬁc Cardiac Dysfunction in CTP:Phosphoethanolamine Cytidylyltransferase (Pcyt2)-Deﬁcient Mice

Phosphatidylethanolamine (PE) is the most abundant inner membrane phospholipid. PE synthesis from ethanolamine and diac-ylglycerol is regulated primarily by CTP:phosphoethanolamine cytidylyltransferase (Pcyt2). Pcyt2 (cid:2) / (cid:3) mice have reduced PE synthesis and, as a consequence, perturbed glucose and fatty acid metabolism, which gradually leads to the development of hyper-lipidemia, obesity, and insulin resistance. Glucose and fatty acid uptake and the corresponding transporters Glut4 and Cd36 are similarly impaired in male and female Pcyt2 (cid:2) / (cid:3) hearts. These mice also have similarly reduced phosphatidylinositol 3-kinase (PI3K)/Akt1 signaling and increased reactive oxygen species (ROS) production in the heart. However, only Pcyt2 (cid:2) / (cid:3) males develop hypertension and cardiac hypertrophy. Pcyt2 (cid:2) / (cid:3) males have upregulated heart AceI expression, heart phospholipids enriched in arachidonic acid and other n-6 polyunsaturated fatty acids, and dramatically increased ROS production in the aorta. In contrast, Pcyt2 (cid:2) / (cid:3) females have unmodiﬁed heart phospholipids but have reduced heart triglyceride levels and altered expression of the structural genes Acta (low) and Myh7 (high). These changes together protect Pcyt2 (cid:2) / (cid:3) females from cardiac dysfunction under conditions of reduced glucose and fatty acid uptake and heart insulin resistance. Our data identify Pcyt2 and membrane PE biogenesis as important determinants of gender-speciﬁc differences in cardiac lipids and heart function.
Registry on Monitoring the Effectiveness and Tolerability of Basal (Plus/Bolus) Regimen with Insulin Glargine and Insulin Glulisine in T2 Diabetes Mellitus Patients in Everyday Practice in Saudi

Type 2 Diabetes Mellitus (T2DM) has emerged as a major global health problem and is one of the most common chronic diseases worldwide. The prevalence of T2DM in Kingdom of Saudi Arabia (KSA) population is high (23%) and has increased by 10% in just one decade. Usually addition of basal insulin is considered as the simplest way to start insulin therapy in patients uncontrolled on oral antidiabetic agents (OADs). In KSA, the majority of patients(60%) recommended to use insulin are treated with premixed insulin.Currently there is limited availability of local (KSA) data documenting the switch from premixed insulin to a basal insulin (Plus/Bolus) regimen. To monitor the effectiveness and tolerability of basal (Plus/Bolus) using Insulin glargine and Insuline glulisine in T2DM patients switched from premixed insulin for achieving the glycemic goal (Glycatedhaemoglobin - HbA1c) as targeted by the treating physician. Multicenter, non-interventional prospective product registry was conducted nationwide across KSA. Males and females aged ≥ 21 years, with type 2 diabetes mellitus, uncontrolled on premixed insulin with HbA1C>7 % and Fasting Blood Sugar >120 mg/dL were selected for this study. Changes in HbA1C from baseline to the end of 6 months and the mean number of hypoglycemic episodes experienced by each patient were measured. Out of 619 enrolled patients, 543 patients completed all study visits. There was statistically significant mean change in HbA1c (2.02%) at visit 3 as compared to baseline. Forty-three percent reduction in hypoglycemia incidence (number of patients experiencing at least one hypoglycemic event) and a 30% reduction in event rate from base line till end of 6 months was also seen in this study. In everyday clinical practice, patients with type 2 diabetes inadequately controlled on premixed insulins experienced significant improvements in glycemic control over 24 weeks after switching to a glargine-based insulin regimen. There was also a significantly lower risk of hypoglycemia and a favorable tolerability profile with this regimen. These findings support the use of a basal-bolus glarginebased regimen in T2DM patients poorly controlled on premixed insulins in KSA.
Effects of Apatinib on the Pharmacokinetics of Nifedipine and Warfarin in Patients with Advanced Solid Tumors

Background and Purpose: Apatinib is a small-molecule tyrosine kinase inhibitor for the treatment of recurrent or progressive advanced-stage gastric adenocarcinoma or gastroesophageal junction cancer. The in vitro inhibition studies suggested that apatinib exerted potent inhibition on CYP3A4 and CYP2C9. To evaluate the potential of apatinib as a perpetrator in CYP450-based drug – drug interactions in vivo, nifedipine and warfarin were, respectively, selected in the present study as the probe substrates of CYP3A4 and CYP2C9 for clinical drug – drug interaction studies. Since hypertension and thrombus are common adverse effects of vascular targeting anticancer agents, nifedipine and warfarin are usually coadministered with apatinib in clinical practice. Methods: A single-center, open-label, single-arm, and self-controlled trial was conducted in patients with advanced solid tumors. The patients received a single dose of 30 mg nifedipine on Day 1/14 and a single dose of 3 mg warfarin on Day 3/16. On Day 9 – 21, the subjects received a daily dose of 750 mg apatinib, respectively. The pharmacokinetics of nifedipine and warfarin in the absence or presence of apatinib was, respectively, investigated. Results: Compared with the single oral administration, coadministration with apatinib contributed to the signi ﬁ cant increases of AUC 0 – 48h and C max of nifedipine by 83% (90% con ﬁ dence interval [CI] 1.46 – 2.31) and 64% (90% CI 1.34 – 2.01), respectively. Similarly, coadministration with apatinib contributed to the signi ﬁ cant increases of AUC 0-t and C max of S-warfarin by 92% (90% CI 1.68 – 2.18) and 24% (90% CI 1.10 – 1.39), respectively. Conclusion: Concomitant apatinib administration resulted in signi ﬁ cant increases in systemic exposure to nifedipine and S-warfarin. Owing to the risk of pharmacokinetic drug – drug interactions based on CYP3A4/CYP2C9 inhibition by apatinib, caution is advised in the concurrent use of apatinib with either CYP2C9 or CYP3A4 substrates.
Al-Najebia power station plant effluents and it's impact on physico-chemical characteristics of Garmat Ali canal.

The physico-chemical characteristics and water quality near thermal effluents of Al-Najebia electrical power station on Garmat Ali canal have been investigated. Seasonal samples were taken through low tide (from summer, 2007 till winter, 2008). Three stations were chosen, serious one was S2 (located closer to the thermal discharge point), these effects were extended to 625 m east far from S2. The effects were reached the highest through summer season at S2 than S3. The highest water temperature was 42C° and the differences between high water temperature between S2 and S3 was 9C° through summer season, high pH values and salinity were 8.3 and 2.2 (ppt) at S2 respectively. Very sharp decline of dissolved oxygen (3.9 mg/l) was noted at S2 and nitrite values (0.23 as μgat N/l) was noted at S1, and high value of BOD was 4.6 mg/l at S2, the highest value of alkalinity was 135 mg/l at S2 through summer season. Maximum values of hardness (mg/l as CaCO3) calcium and magnesium (mg/l) were 760, 425 and 365 respectively; TDS was 1710 mg/l at S2 through summer season. Maximum values of nitrite and nitrate (as μgat N/l) were 1.30 and 35 at S2 due to many bio-chemical reactions with were happened during high water temperatures.
An Implementation of Local Sparsity Ratio-Mine Algorithm for Arabic Text Categorization

 Abstract — Because of the complexities of the Arabic language and the tremendous number of text documents existed in the internet, the development of Arabic text categorization systems is a challenging problem for researchers. In this paper, we developed a new Arabic text classification system based-on Local Sparsity Ratio Mine Algorithm (LSC-mine). The developed system is capable of detecting outlier points in a spatial space; the discovering process is accomplished through computing the Local sparsity ratio (LSC), which indicates the outlier-ness of a certain point. Several experiments have been conducted to ensure the success of the developed system. The system has been implemented and tested using datasets of different categories collected and gathered from online Arabic documents websites.
Scaling of Star Polymers with 1 - 80 Arms

: We present large statistics simulations of 3-dimensional star polymers with up to f ) 80 arms and with up to 4000 monomers per arm for small values of f . They were done for the Domb - Joyce model on the simple cubic lattice. This is a model with soft core exclusion which allows multiple occupancy of sites but punishes each same-site pair of monomers with a Boltzmann factor v < 1. We use this to allow all arms to be attached at the central site, and we use the “magic” value v ) 0.6 to minimize corrections to scaling. The simulations are made with a very efficient chain growth algorithm with resampling, PERM, modified to allow simultaneous growth of all arms. This allows us to measure not only the swelling (as observed from the center-to-end distances) but also the partition sum. The latter gives very precise estimates of the critical exponents (cid:231) f . For completeness we made also extensive simulations of linear (unbranched) polymers which give the best estimates for the exponent (cid:231) .
Design of A Data Transmission Unit for An Autonomous Vehicle

-The vehicle equipped with autonomous driving capability detects the environment, locates its position, and operates appropriately to go to the specified destination safely without human input. For developing such autonomous vehicles many complex algorithms are used which involve various computer science fields such as Machine Learning, Artificial Intelligence, Neural Networks and Image Processing. The autonomous vehicle needs to provide accurate output in real time environment which in turn increases the computational power of the system. This paper proposes to build an end-to-end autonomous driving system based on most recently published system designs from academic research and industry practitioners. The proposed Data Transmission Unit comprises of a central wide angle camera mounted on the dashboard of a vehicle. The live video stream from the camera is fed to the Convolutional neural network (CNN) as input which in turn predicts the steering angle for every frame. The predicted steering angle is calibrated based on the designed steering and brake mechanism of the vehicle.
Silverleaf Whiteﬂy Induces Salicylic Acid Defenses and Suppresses Effectual Jasmonic Acid Defenses 1[W][OA]

The basal defenses important in curtailing the development of the phloem-feeding silverleaf whiteﬂy ( Bemisia tabaci type B; SLWF) on Arabidopsis ( Arabidopsis thaliana ) were investigated. Sentinel defense gene RNAs were monitored in SLWF-infested and control plants. Salicylic acid (SA)-responsive gene transcripts accumulated locally ( PR1 , BGL2 , PR5 , SID2 , EDS5 , PAD4 ) and systemically ( PR1 , BGL2 , PR5 ) during SLWF nymph feeding. In contrast, jasmonic acid (JA)- and ethylene-dependent RNAs ( PDF1.2 , VSP1 , HEL , THI2.1 , FAD3 , ERS1 , ERF1 ) were repressed or not modulated in SLWF-infested leaves. To test for a role of SA and JA pathways in basal defense, SLWF development on mutant and transgenic lines that constitutively activate or impair defense pathways was determined. By monitoring the percentage of SLWF nymphs in each instar, we show that mutants that activate SA defenses ( cim10 ) or impair JA defenses ( coi1 ) accelerated SLWF nymphal development. Reciprocally, mutants that activate JA defenses ( cev1 ) or impair SA defenses ( npr1 , NahG) slowed SLWF nymphal development. Furthermore, when npr1 plants, which do not activate downstream SA defenses, were treated with methyl jasmonate, a dramatic delay in nymph development was observed. Collectively, these results showed that SLWF-repressed, JA-regulated defenses were associated with basal defense to the SLWF. well-characterized SA-, JA-, and ET-defense genes. We show that SLWFs induced SA-signaling pathways and suppressed or did not alter expression of JA/ET-regulated genes. To test for the role of these defense pathways in basal resistance, ﬁve Arabidopsis SA and JA mutant/transgenic lines ( nonexpressor of PR1 [ npr1 ], constitutive immunity10 [ cim10 ], coronatine insensitive1 [ coi1 ], constitutive expression of vsp1 [ cev1 ], and NahG) and wild-type Columbia were utilized to monitor SLWF nymphal development and sentinel SA- and JA-defense gene RNAs. These experiments and infestation studies with methyl jasmonate (MeJA)-treated npr1 plants demonstrated that basal defenses suppressed by SLWF feeding were critical for constraining nymphal development.
The Magellanic Clouds

The Magellanic Clouds continue to attract much interest. New data from observations at all wavelengths appear frequently and contribute valuable information regarding the Clouds as galaxies as well as their content of gas, dust and stellar generations. Detailed studies of individual objects and clusters add important clues to our knowledge of stellar evolution. Numerical simulations take us closer to understanding the interaction between the Small and the Large Clouds as well as between the Clouds and the Galaxy. Here, some recent results regarding the composition, structure and evolution of the Magellanic system are presented.
Myosin V: regulation by calcium, calmodulin, and the tail domain

alcium activates the ATPase activity of tissue-puriﬁed myosin V, but not that of shorter expressed constructs. Here, we resolve this discrepancy by comparing an expressed full-length myosin V (dFull) to three shorter constructs. Only dFull has low ATPase activity in EGTA, and signiﬁcantly higher activity in calcium. Based on hydrodynamic data and electron microscopic images, the inhibited state is due to a compact conformation that is possible only with the whole molecule. The paradoxical ﬁnding that dFull moved actin in EGTA suggests that binding of the molecule to the substratum turns it on, perhaps mimicking cargo activation. Calcium slows, but does not stop the rate of actin movement if excess calmodulin (CaM) is present. Without excess CaM, calcium binding to the high afﬁnity sites dissociates CaM and stops motility. We propose that a folded-to-extended conformational change that is controlled by calcium and CaM, and probably by cargo binding itself, regulates myosin V’s ability to transport cargo in the cell. transport. Path B: a hypothetical pathway
Completely Bounded Characterization of Operator Algebras with Involution

In this paper we study the completely bounded anti-isomorphisms on operator algebras, that work similarly to the involutions with the exception for the property of being completely isometric. We elaborate the Blecher's characterization theorem for operator algebras to make it applicable to the so-called operator $K$-algebras with completely bounded reflexive anti-isomorphism. We also establish a connection of this result with the notion of smooth $C^*$-modules, that play an important role in Mesland's approach to Baaj-Julg picture of $KK$-theory.
Quantitative methods II: Issues of inference in quantitative human geography

Although classical significance testing is the most commonly used inferential technique in quantitative geography, it is far from the only choice, and in some circumstances may not be the most appropriate. In the statistical literature and other disciplines, its utility has come under question in a number of contexts. This report overviews current progress in the development of quantitative inferential approaches, and considers their use and appropriateness in a number of human geographical contexts.
USING MULTI-ENCODER NMT IN ENGLISH-MALAY TRANSLATION

Neural Machine Translation (NMT) is one of the most popular approaches for language translation. In this paper, we proposed to use multi-encoder NMT for English to Malay translation by using different resources as an extra information for NMT. TensorFlow is the existing toolkits that used in this research paper. By using multi-encoder NMT, we try to increase the BLEU score for a specific domain and general domain.
Mitochondrial dysfunction and calcium deregulation by the RanBP9-coﬁlin pathway

Mitochondrial dysfunction and synaptic damage are important features of Alzheimer’s disease (AD) associated with amyloid (cid:1) (A (cid:1) ) and tau. We reported previously that the scaffolding protein RanBP9, which is overall increased in brains of patients with AD and in mutant APP transgenic mice, simultaneously promotes A (cid:1) generation and focal adhesion disruption by accelerating the endocytosis of APP and (cid:1) 1-integrin, respectively. Moreover, RanBP9 induces neurodegeneration in vitro and in vivo and mediates A (cid:1) -induced neurotoxicity. Here we show in primary hippocampal neurons that RanBP9 potentiates A (cid:1) induced reactive oxygen species (ROS) overproduction, apoptosis, and calcium deregulation. Analyses of calcium-handling measures demonstrate that RanBP9 selectively delays the clearance of cytosolic Ca 2 (cid:2) mediated by the mitochondrial calcium uniporter through a process involving the translocation of coﬁlin into mitochondria and oxidative mechanisms. Further, RanBP9 retards the anterograde axonal transport of mitochondria in primary neurons and decreases synaptic mitochondrial activity in brain. These data indicate that RanBP9, coﬁlin, and A (cid:1) mimic and potentiate each other to produce mitochondrial dysfunction, ROS overproduction, and calcium deregulation, which leads to neurodegenerative changes reminiscent of those seen in AD. —Roh. S. -E. , Woo, Mitochondrial dysfunction and calcium deregulation by the RanBP9-coﬁlin pathway. J. 27, 4776–4789 (2013).
Model in Estimating Air Conditioning Energy Consumption in Residential Houses

： We s し Lrveyed the usagc of uir conditioner in living roems and bedrooms to study the relationship between thennal environmcnt and the occurrence of air conditioncr On control ． The11 ， a thermal envirQnment contro ］ behavior modd was developed wi1h the survey rcsults ． Moreover ． it was incoiporated illto tllo model we proposed befbre to cstimatc air condition − ing energy consumptioll with thc iIlfluence ofcross ventilation ． FinaHy ， wc studied the difference betweerl tllc rcsults calculated using typical lnethod and our mcth 〔｝ d ． The results are as follow ： DThe avcragc tcmperature ofOn control the and bcf and evelling durillg n ， while in the momillg it is about 2 ． 5 ℃ and be