Miracle-dz/UniFAR-FTUs huggingface dataset:
Methodological Implications of Feminist and Poststructuralist Views of Science By

The range of answers to the question, "What is Science? " has literally reached beyond the capability of any one person to adequately understand and summarize. This paper discusses the concept of the so-called "value-free" science, and contrasts this traditional mode of inquiry with the new modes of thought espcused by advocates of feminism and poststructuralism. It is concluded that the current conflict and disagreement over the nature of science is a positive situation and one which brings together many differing perspectives to the benefit of research. (PR) *********************************************************************** Reproductions supplied by EDRS are the best that can be made from the original document. *********************************************************************** Methodological Implications of Feminist and Poststructuralist Views of Science
Small molecules inhibitors of the heterogeneous ribonuclear protein A18 (hnRNP A18): a regulator of protein translation and an immune checkpoint

Abstract We have identified chemical probes that simultaneously inhibit cancer cell progression and an immune checkpoint. Using the computational Site Identification by Ligand Competitive Saturation (SILCS) technology, structural biology and cell-based assays, we identify small molecules that directly and selectively bind to the RNA Recognition Motif (RRM) of hnRNP A18, a regulator of protein translation in cancer cells. hnRNP A18 recognizes a specific RNA signature motif in the 3′UTR of transcripts associated with cancer cell progression (Trx, VEGF, RPA) and, as shown here, a tumor immune checkpoint (CTLA-4). Post-transcriptional regulation of immune checkpoints is a potential therapeutic strategy that remains to be exploited. The probes target hnRNP A18 RRM in vitro and in cells as evaluated by cellular target engagement. As single agents, the probes specifically disrupt hnRNP A18–RNA interactions, downregulate Trx and CTLA-4 protein levels and inhibit proliferation of several cancer cell lines without affecting the viability of normal epithelial cells. These first-in-class chemical probes will greatly facilitate the elucidation of the underexplored biological function of RNA Binding Proteins (RBPs) in cancer cells, including their effects on proliferation and immune checkpoint activation.
Facility Risk Management of Common Conduits

Common conduits are indispensable for the populous metropolitans and the advanced industrial parks, such as the Hsinchu Science-Based Industrial Park. The various pipelines in the common conduits serve not only as the nerve system but also the circulating system of the industrial parks. The maltiple functions of the common conduits may affect not only the yearly hundred-billion-dollar productions of the high-tech industrial park but also the welfare of millions of people's life. It is therefore very important to ensure the maintainability and successful operations of the common conduits. However, the common conduit is still not popular in many developing countries including Taiwan. Important historical data related to risk analysis of the common conduit are not available. Moreover, the serious damages of infrastructure caused by Chi-Chi (921) Earthquake in 1999 has exposed the insufficiency of risk management in the public infrastructure in Taiwan.Thus, this paper aims at developing a facility risk management method for common conduits. A case strudy of a local high-tech industrial park is performed for illustration purpose. The goal of the paper is to provide a practical reference for developing facility risk management programs of future common conduit projects.
Personalized well-being monitoring using wearable sensors

In the EU, 1.7 million people aged less than 75 years died in 2013. 34% of those deaths could have been avoided with better healthcare. This clearly states the need for healthcare improvement. Most healthcare research focuses on disease rather than health. However, people are interested predominantly in health and wellbeing. This seminar presents an overview of computer science studies on well-being. Four well-being factors are thoroughly analysed, i.e., stress, emotions, sleep and physical activity. For the related studies on each of these factors, critical judgment is presented including positive aspects, negative aspects and suggestions for upgrading the current condition. In addition, a novel approach for personalized wellbeing monitoring is proposed. The proposed approach consists of three layers: a sensing layer which includes wrist device and smartphone for providing data from physiological sensors; a machine-learning layer, which contains machine-learning models for monitoring each of the four well-being factors; and a recommender layer which provides personalized recommendations to the user for improvement of the four well-being factors. The suggested novel approach should upgrade the existing conditions from three aspects: combined monitoring of four well-being factors; personalization of the machine-learning models for monitoring of the well-being factors; and personalized recommendations for improving of the well-being factors.
Towards Microphone Selection Based on Room Impulse Response Energy-Related Measures

In a room where several distant microphones are capturing signals in parallel, the quality of the recorded speech signals strongly depends on the characteristics of the room impulse responses that describe the wave propagation between each source and each microphone. In this paper we present an initial attempt to investigate the possibility of selecting the micro-phone that offers the best quality of speech. As we want to apply it to an automatic speech recognition system, we aim to select the microphone according to some optimization criterion that has been inferred from the recognition rate in a prior learning process. Several energy-related measures that carry relevant information of the room impulse response are being considered. They should be estimated directly from the speech signal, possibly in real time, but avoiding the need to estimate the whole room impulse response. In this paper, we present the rationale behind the intended investigation, and offer preliminary experiments for a large vocabulary continuous speech recognition task which show how microphone selection using an ideal relative energy measure can largely improve the recognition rate.
Design of Control for Battery Storage Unit Converter

Battery storage will play an important part of systems supplied by photovoltaic or other renewable energy grid-connected sources. It is life-important to use appropriate battery management technique to achieve desired efficiency, long-life of battery unit and favorable costs. To ensure these demands, a precise control of batteries should consist of accurate State-of-Charge (SOC) estimation, effective balancing and charging control. The correct value of SOC is estimated using combination of Coulomb Counting and Kalman Filter methods. Performance of control for DC-DC converter with Double tiered capacity balancing circuit is analyzed. Battery management is verified using MATLAB/Simulink.
Optical characterization for nearly spherical gold colloidals via their polarization response

We optically characterized colloidal gold nanoparticles using polarized light scattering which is utilized to investigate both optical anisotropy and aspect ratio of the particle and to observe particle's rotational dynamics. By monitoring time-trace of the polarized scattering from a particle, we could observe rotational dynamics as fluctuations in the measured anisotropy. With typical particle dimension of 97 nm, the maximum anisotropy was measured experimentally to be 0.1 to 0.5, and with comparison to our analytical model, this range is equivalent to an aspect ratio range of 1 to 1.3, which reveals that the colloidals are predominately spherical as predicted by transmission electron microscope (TEM) images analysis. Our method has the advantage to be simple, easy to implement, and can yield access to different projections of the particle due to its rotation. Polarized light scattering can be an ultrasensitive measure for biosensing applications.
Title How well do test case prioritization techniques supportstatistical fault localization

In continuous integration, a tight integration of test case prioritization techniques and fault-localization techniques may both expose failures faster and locate faults more effectively. Statistical fault-localization techniques use the execution information collected during testing to locate faults. Executing a small fraction of a prioritized test suite reduces the cost of testing, and yet the subsequent fault localization may suffer. This paper presents the first empirical study to examine the impact of test case prioritization on the effectiveness of fault localization. Among many interesting empirical results, we find that coverage-based techniques and random ordering can be more effective than distribution-based techniques in supporting statistical fault localization. Furthermore, the integration of random ordering for test case prioritization and statistical fault localization can be effective in locating faults quickly and economically. Keywords—Continuous integration; software process integration; test case prioritization; fault localization
The Translatability of Some Qur’anic Verbal Irony into English: A Comparative Stylistic and Pragmatic Analytical Study

The current study aims to examine through lexical stylistic analysis and comparison, the differences and the disparateness of meaning and style in rendering the Quranic verbal irony into English, in the work of Mohammed. A.S Abdel Haleem, Mohammed. M Pickthall and Mohammed Khan and Mohammed Taj Al-Din Al-Hilali . Also, the study aims to investigate how the three translators deal with the Quranic verbal irony in their translations into English. This has its powerful consequence in attaining a better understanding on the part of the Holy Quran translators and subsequently of English language receptors in general and for non- Arabic Muslims in particular, where the Qur’anic verbal irony concerned. Also, the study aims to identify the translation strategies employed by the three translators in rendering the Quranic verbal. irony Moreover, the study revealed that the Qur’anic verbal irony is conspicuous occurrence in the Holy Quran and that the process of rendering them into English is generally problematic for the reasons such as linguistic and cultural divergences and discrepancies. Finally, the study gives two ideas; firstly, the equivalence in translation should be examined as a concept that holds a place on a scale that can begin very equivalent to inequivalent. Secondly, better translation of the Holy Quran should bear intelligibility in terms of a total impact of the Message on the language receptor.
Display of Microbial Glucose Dehydrogenase and Cholesterol Oxidase on the Yeast Cell Surface for the Detection of Blood Biochemical Parameters

High levels of blood glucose are always associated with numerous complications including cholesterol abnormalities. Therefore, it is important to simultaneously monitor blood glucose and cholesterol levels in patients with diabetes during the management of chronic diseases. In this study, a glucose dehydrogenase from Aspergillus oryzae TI and a cholesterol oxidase from Chromobacterium sp. DS-1 were displayed on the surface of Saccharomyces cerevisiae, respectively, using the yeast surface display system at a high copy number. In addition, two whole-cell biosensors were constructed through the immobilization of the above yeast cells on electrodes, for electrochemical detection of glucose and cholesterol. The assay time was 8.5 s for the glucose biosensors and 30 s for the cholesterol biosensors. Under optimal conditions, the cholesterol biosensor exhibited a linear range from 2 to 6 mmol·L−1. The glucose biosensor responded efficiently to the presence of glucose at a concentration range of 20–600 mg·dL−1 (1.4–33.3 mmol·L−1) and showed excellent anti-xylose interference properties. Both biosensors exhibited good performance at room temperature and remained stable over a three-week storage period.
EVALUATION REPORTS

Since its inception, WFP has supported projects aimed at assisting people to protect, develop or use natural resources better. The majority of these types of projects have been geographically focused on poor, marginal areas where environmental degradation was evident and where most people were suffering from food insecurity. The links between hunger, poverty and environmental degradation are quite apparent: the rural poor usually have little land; the soils are often fragile and only marginally productive. The farmers can afford few inputs and often have little choice but to over-exploit the land, thus exacerbating their vulnerability to hunger—and even famine.
A research of rule discovery method for process object based on large scale data

a model of process object is proposed in this paper based on the large scale data generated in process industry. According to the characteristics of process object model, a new method of rule discovery method for process object based on large scale history data is proposed. This method named T-C-AC/T (Time series-Clustering-Association-Chain/Tree Flow) can be divided into several steps as: the raw data set will be adjusted by matching time series according to monitoring point in each link of process industry; then based on the adjusted data set, all monitoring points will be clustered, and the clustering result will be calculated to obtain 2-itemsets association rules; then these 2itemsets rules will be used to establish the association-chain; at last, by computing each link in process object, the rule of producing states will be discovered and the knowledge base will be created. This method has been applied in some production processes of thermal power, and good effect has been achieved. Keywords—process object; time series; tssociation rule; state chain
Magneto-optical readout of dark exciton distribution in cuprous oxide

An experimental study of the yellow exciton series in Cu2O in strong magnetic fields up to 32 T shows the optical activation of direct and phonon-assisted paraexciton luminescence due to mixing with the quadruple allowed orthoexciton state. The observed phonon-assisted luminescence yields information on the statistical distribution of occupied states. Additional time-resolved experiments provide a unique opportunity to directly determine the time evolution of the thermodynamical properties of the paraexciton gas. Because the lifetime of paraexciton is hardly affected by the optical activation in a strong magnetic field, this opens new possibilities for studies aiming at Bose-Einstein condensation of excitons in bulk semiconductors.
Expression of TRF 2 and GAPDH in the aging of the in vitro ovarian surface epithelial cells

GAPDH can bind single-strand telomere DNA both in vitro and in vivo. Thus, it was hypothesised that GAPDH has an important role in protecting the telomeres, role that could be shared with TRF2, a well-known telomeric protein involved in a myriad of functions related to telomere homeostasis. Objective: The aim of this study was to determine if there was a correlation between the expression of these genes in the in vitro ovarian surface epithelium. Materials and methods: The relative expression of each gene was established by qRT-PCR in primary cell cultures of the ovarian surface epithelium from 22 healthy mestizo Colombian donors. Results: The Kendall and Spearman non-parametric tests established a significant correlation between the levels of expression in subsequent passages of the cell line, in an age-independent way. Conclusion: Our findings suggest a synergistic effect between TRF2 and GAPDH that could counter telomere shortening in vitro.
Predictors of achieving remission in schizophrenia patients treated with paliperidone palmitate 3-month formulation

Purpose Long-acting injectable (LAI) antipsychotic paliperidone palmitate 3-month formulation (PP3M) is indicated in the United States for the treatment of schizophrenia only after adequate treatment with paliperidone palmitate 1-month formulation (PP1M) for ≥4 months. This analysis aimed to identify patient and disease characteristics during PP1M treatment associated with greater likelihood of achieving remission after transition to PP3M. Methods A post hoc analysis of a randomized, Phase III, double-blind, noninferiority trial of PP3M vs PP1M (ClinicalTrials.gov identifier: NCT01515423) was conducted in adult patients with schizophrenia. Patients achieving clinical stability after 17 weeks of open-label PP1M were randomized to 48 weeks of double-blind treatment with PP3M or PP1M. The primary objective of this exploratory post hoc analysis was to identify demographic and/or clinical variables associated with persistent remission after treatment with PP3M. Multiple logistic regression analysis identified the following significant predictors of remission: Positive and Negative Syndrome Scale (PANSS) Marder negative symptom factor score, Clinical Global Impression-Severity (CGI-S) total score, and Personal and Social Performance (PSP) total score. Results At double-blind baseline, a 1-point reduction in Marder negative symptom factor score was associated with a 20% increase in the odds of achieving remission after PP3M treatment; 1-point reduction in CGI-S was associated with a doubling in remission odds; and 7- and 10-point improvements in PSP scores, respectively, were associated with 42% and 65% increases in remission odds. Conclusion Patients with early clinically meaningful improvements in disease symptoms and severity while establishing stable PP1M dosage are more likely to achieve remission after transition to PP3M.
The void at the heart of rules: Routines in the context of rule-following

This paper is an attempt to understand how rules operate in organisations. I focus on the links between organisational routines and rules that are defined as incomplete since they come to their application. I analyse the role of routines in managing the incompleteness of rules. I present a case study where management introduced a productivity bonus in the middle of 1992. This allows to study in what extent the new rule modifies the prevailing routines of work organisation. Based on team observations, interviews, and statistics that I carried out over a period of nine years (1992-2000), I show that in an initial period, the productivity bonus has partially biased the tasks selection process. In a second period - "the normal period" - our observations indicate that following the rules consists in translating the abstract rules into concrete reference points, and adding in what the rules have not specified. The translation process conducts to a routine since the interpretation is stabilised. Routines provide a pragmatic, local, and temporary solution to the incompleteness of rules. Since routines emerge only in the course of action, they come with no guarantee of success. That constitutes their dynamic.
Comparative Study of Different Similarity Functions in Collaborative Filtering

______________________________ Abstract - Recommendation System is an information filtering technique, which provides users with information, which they may be interested in. It serves as a guide for a user to navigate through a large dataset helping them in discovering products of their interest. In the last two decades, more than 250 research articles were published about research-paper recommendation systems. On one hand, it is interesting to have many recommendation techniques to produce an output as each has its own advantages but it also makes it strenuous to choose the right fit to address each scenario. Also it is challenging to turn these recommendation techniques to be used in real world situations. So, it is important to help the designing team choose the best technique to get optimal solutions in order to improve serviceability and make it cost efficient. In this paper, we here list out all the techniques i.e. the similarity functions used in collaborative filtering for ready reference and propose genetic function for genetic recommend generating method. On a dataset from MovieLens and different collaborative filtering approaches, experiments were performed, in order to evaluate proposal. Top three recommendations are shown using different similarity functions in collaborative filtering approach.
Experiencing Shared Leadership: Teachers’ Reflections

This eighteen month qualitative study documents an elementary school's implementation of a shared leadership environment. Data were collected from leadership team meetings, faculty meetings, informal interviews, and formal interviews with the leadership team. Findings indicate positive perceptions concerning collaboration and the development of an atmosphere of open communication. Respondents expressed disappointment with the level of decision-making opportunities, the development of non-student oriented goals, a lack of trust between administrators and teachers, and were confused about teacher roles and responsibilities. Shared leadership environments may be enhanced by providing clearer expectations for teachers and more opportunities for teacher training.
Growth Dynamics of Pairwise Novelty in Social Annotation

In social annotation, the vocabulary of tags continues to increase following so-called Heaps’ law. However, it has not been extensively studied how the variation of combinatorial usage of tags increases as the web service grows. We introduce the idea of “combinatorial novelty” and investigate how it emerges in both the baseline mathematical model and the empirical web data.
Landfill leachate : an alternative water source for Alberta oil and gas development

The Alberta oil and gas industry continually seeks ways to reuse wastewaters within the context of environmental regulations. This thesis examines the use of landfill leachate as an alternative source to freshwater in the formulation of water-based drilling fluid. Key drilling fluid parameters of interest were accordingly compared to Class II leachate and freshwater samples. The concurrent data were also evaluated with respect to Alberta’s regulatory criteria to assess the risk to humans and the environment. The results showed that the reuse of landfill leachate presents several technical challenges and opportunities. Although landfill leachate quality and quantity vary spatially and temporally, its use nonetheless may positively offset drilling fluid chemical additives and freshwater volumes requirements. Adaptive and optimal designed management approaches would undoubtedly promote landfill leachate use by industry if adequately supported by enlightening regulations and reduced administrative burden. O&G WATER CONSERVATION ALTERNATIVE 5 Table of