Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of an Interprofessional Learning Experience for Telephone Consultations

Background and Purpose There is limited training for healthcare students in the performance of telephone consultations. To facilitate communication between healthcare professionals when face-to-face interactions are not possible, a telephone consultation simulation was developed. The simulation involved students in a doctor of physical therapy program and senior medical students. This study aimed to explore the development and suitability of a simulated case with a focus on interprofessional telephone consultation. Methods A convenience sample of 28 physical therapy students and 38 medical students from two institutions in southwest Virginia participated in the simulation experience. To assess the outcomes of the simulation on interprofessional communication, the IPASS verbal handoff assessment was performed by the participants and focus group interviews occurred immediately following the experience. In addition, an assessment of key information provided during the conversation was performed for each of the seven interprofessional groups. Results Students demonstrated near perfect agreement on the IPASS assessment. Five of the seven interprofessional groups perceived that they were able to communicate key information and collectively agree upon a recommendation for the continuation of the patient assessment. The two groups that demonstrated more difficulty with communication appeared to struggle with communicating the patient’s past medical history relevant to the current situation, despite the majority of students feeling confident in their communications. In addition, two themes were presented during the interprofessional focus group interviews: 1) clear communication to maintain patient safety and 2) efficiently conveying the patient’s background. Discussion The health professions students participating in the scenario were able to consistently note the communication skills observed and reflect upon the need for clear communication between providers during a patient consultation. Key components of an efficient telephone consultation were identified, along with opportunities to improve this type of interaction between health professionals.
Analysis of the Current and Future Prediction of Land Use/Land Cover Change Using Remote Sensing and the CA-Markov Model in Majang Forest Biosphere Reserves of Gambella, Southwestern Ethiopia

This study aimed to evaluate land use/land cover changes (1987–2017), prediction (2032–2047), and identify the drivers of Majang Forest Biosphere Reserves. Landsat image (TM, ETM+, and OLI-TIRS) and socioeconomy data were used for the LU/LC analysis and its drivers of change. The supervised classification was also employed to classify LU/LC. The CA-Markov model was used to predict future LU/LC change using IDRISI software. Data were collected from 240 households from eight kebeles in two districts to identify LU/LC change drivers. Five LU/LC classes were identified: forestland, farmland, grassland, settlement, and waterbody. Farmland and settlement increased by 17.4% and 3.4%, respectively; while, forestland and grassland were reduced by 77.8% and 1.4%, respectively, from 1987 to 2017. The predicted results indicated that farmland and settlement increased by 26.3% and 6.4%, respectively, while forestland and grassland decreased by 66.5% and 0.8%, respectively, from 2032 to 2047. Eventually, agricultural expansion, population growth, shifting cultivation, fuel wood extraction, and fire risk were identified as the main drivers of LU/LC change. Generally, substantial LU/LC changes were observed and will continue in the future. Hence, land use plan should be proposed to sustain resource of Majang Forest Biosphere Reserves, and local communities' livelihood improvement strategies are required to halt land conversion.
Revealing the active microbiome connected with the rhizosphere soil of maize plants in Ventersdorp, South Africa

Abstract We conducted shotgun metagenomics sequencing of the maize rhizosphere and bulk soils in Ventersdorp, South Africa. Information on the structural composition and functional capabilities of microbial communities in the maize rhizosphere are provided by the data. Characterising the functional potentials of rhizosphere microbiomes gives an opportunity to link the microbiome to plant growth and health and provides the possibility of discovering new plant-beneficial genes that could enhance agricultural sustainability.
Remote Limb Ischemic Postconditioning Protects against Ischemic Stroke via Modulating Microglia/Macrophage Polarization in Mice

Aim The protection against ischemia/reperfusion injury mediated by remote limb ischemic postconditioning (RIPC) shows great clinical value in ischemic stroke therapy, but the particular mechanism of RIPC remains unclear. Methods We carried out middle cerebral artery occlusion/reperfusion (MCAO/R) surgery on C57BL/6 male mice. RIPC was generated by 10-minute occlusion followed by the same period of reperfusion of the bilateral hind limb femoral artery and repeated for 3 cycles. Infarct size and neurological score were performed to assess stroke outcomes. Ly6Chi monocytes were quantified in the blood and brain by flow cytometry. Real-time PCR, ELISA, and immunofluorescence were utilized to detect phenotype of proinflammatory M1 and anti-inflammatory M2 microglia/macrophage. Nuclear factor κB (NF-κB) and peroxisome proliferator-activated receptor γ (PPARγ) levels were detected using Western blot. Results At 24 and 72 h after MCAO, RIPC drastically attenuated infarct size and ameliorated the neurological deficits of mice and facilitated transmigration of Ly6Chi monocytes to the brain postischemia reperfusion. Furthermore, RIPC contributed to increased M2 and reduced M1 microglia/macrophage through inhibiting NF-κB and promoting PPARγ activation. Conclusion Our results reveal pharmacological effect of RIPC in promoting microglia/macrophage transferring from M1 to M2 phenotype after MCAO/R in mice, which provides theoretical support for the therapeutic effect of RIPC in ischemic stroke.
Comparison of Pain Scores Among Patients Undergoing Conventional and Novel Panretinal Photocoagulation for Diabetic Retinopathy: A Systematic Review

Purpose To summarize key findings from a systematic review focusing on pain as an adverse outcome of panretinal photocoagulation (PRP) among patients with diabetic retinopathy. Design Systematic review. Methods We systematically searched articles in major databases from July to September 2020. Studies that compared pain outcomes of PRP among diabetic patients who underwent conventional single-spot laser (SSL), conventional multi-spot laser (MSL), and/or novel navigated laser (NNL) were included. The Cochrane RoB 2 tool and ROBINS-I tool were used to evaluate the risk of bias of the included randomized controlled trials (RCTs) and controlled clinical trials (CCTs), respectively. Results We included 13 RCTs and 4 CCTs. Thirteen studies were included for Comparison 1 (Conventional SSL versus Conventional MSL), 3 studies were included for Comparison 2 (NNL versus Conventional MSL), and 3 studies were included for Comparison 3 (NNL versus Conventional SSL). A total of 783 patients and 1961 eyes were included in this review. The review showed that NNL yielded the lowest pain scores, followed by conventional MSL, then by conventional SSL. Conclusion This review summarizes findings of multiple studies that reported pain as an adverse outcome of PRP among patients with advanced diabetic retinopathy. Data from RCTs with mostly some concerns for bias (RoB 2 tool) and CCTs with mostly moderate risk of bias (ROBINS-I tool) show benefit of using MSL over SSL, and NNL over conventional systems for PRP in diabetic retinopathy, considering pain as the primary outcome.
Hybrid mechanics. II

We recently published a new method for the calculation of the time evolution of a wave function. We used an accurate approximate method to calculate the time propagator for a finite time Δt. Numerical calculations showed that this scheme works quite accurately, but that it is not more efficient than conventional methods. In this paper we propose to use a very fast and simple, but less accurate semiclassical method for the calculation of the time propagator. The approximation consists in the replacement of the Hamiltonian by a quadratic approximation around the center of the evolving wave packet called thawed Gaussian dynamics. We show by numerical examples in one and two dimensions that, despite this crude approximation, we achieve nearly the same accuracy as in the foregoing paper, but with an efficiency that is typically more than an order of magnitude better. We further show that the method is able to describe tunneling and long time dynamics (e.g., 1000 vibrational periods).
A protocol for systematic review and meta-analysis

Background: Coronavirus disease 2019 (COVID-19) is an acute respiratory infectious disease which making people difficult to breathe and often accompanied with headache. Acupuncture have been proved the therapeutic effect on headache, but there has been no high-quality evidence on acupuncture for the headache in COVID-19. This study is designed to evaluate the effectiveness and safety of acupuncture for headache in COVID-19. Methods: Randomized controlled trials from December 2019 to July 2021 will be included without restrictions on language or publication date. PubMed, EMBASE, Cochrane Library, Web of Science, Chinese Biomedical Databases, China National Knowledge Infrastructure, Wanfang database, and VIP database will be searched. Two researchers will independently select studies, extract data and evaluate study quality. Cochrane risk of bias tool for randomized trials will be used to assess the risk of bias of included studies. Statistical analyses will be performed using the Review Manager V.5. 3 and stata 14.0. Ethics anddissemination: This study will not involve personal information. Ethical approval will not be required. We will publish the results in a peer-reviewed journal. PROSPERO Trial registration number: CRD42021270722 Abbreviations: COVID-19 = coronavirus disease 2019, PRISMA-P = preferred reporting items for systematic reviews and metaanalysis protocol, SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2.
Ionic Liquid Extractants in Molecular Diluents: Extraction Behavior of Plutonium (IV) in 1,3-Diketonate Ionic Liquids

Abstract Room temperature ionic liquids (RTILs) containing β-diketonate anions have been prepared and studied for the extraction of 239Pu(IV), 233U(VI), and 241Am(III) from nitric acid medium. The ionic liquids such as alkylquaternaryammonium thenoyltrifluoroacetonate (R4NTTA), and 1-alkyl-3-methylimidazolium thenoyltrifluoroacetonate (amimTTA), with methyl, butyl, hexyl, heptyl, and octyl moieties have been prepared and characterized by 1H and 13C nmr and IR spectroscopy. The distribution ratio of plutonium(IV) (D Pu(IV)) in a solution of tri-n-octylmethylammonium thenoyltrifluoroacetonate (TOMATTA) present in tri-n-octylmethylammonium bis(trifluoromethylsulfonyl)imide (TOMANTf2) and amimTTA in amimNTf2 was studied as a function of various parameters. The unique property of β-diketonate ionic liquids, namely, the miscibility in molecular diluents, was exploited to elucidate the mechanism of Pu(IV) extraction in these ionic liquids.
Health Services Use by Children in the Welfare System Who Died by Suicide

Using data from multiple child-serving agencies, we examine characteristics and health service use patterns of youth suicide decedents with child welfare system involvement. OBJECTIVES: To examine characteristics and health service use patterns of suicide decedents with a history of child welfare system involvement to inform prevention strategies and reduce suicide in this vulnerable population. METHODS: A retrospective matched case-control design (120 suicide decedents and 1200 matched controls) was implemented. Suicide decedents included youth aged 5 to 21 who died by suicide and had an open case in Ohio’s Statewide Automated Child Welfare Information System between 2010 and 2017. Controls were matched to suicide decedents on sex, race, and ethnicity. Comparisons were analyzed by using conditional logistic regressions to control for matching between the suicide and control groups. RESULTS: Youth in the child welfare system who died by suicide were significantly more likely to experience out-of-home placements and be diagnosed with mental and physical health conditions compared with controls. Suicide decedents were twice as likely to access mental health services in the 1 and 6 months before death, regardless of the health care setting. A significantly higher percentage of suicide decedents used physical health services 6 months before their death or index date. Emergency department visits for both physical and mental health conditions were significantly more likely to occur among suicide decedents. CONCLUSIONS: Suicide decedents involved in the child welfare system were more likely to use both mental and physical health care services in the months before their death or index date. Findings suggest that youth involved in the child welfare system may benefit from suicide prevention strategies in health care settings.
Effects of multiple stressors on northern leopard frogs in agricultural wetlands

Abstract Abstract Natural and anthropogenic stressors, including parasites and pesticides, may induce oxidative stress in animals. Measuring oxidative stress responses in sentinel species that are particularly responsive to environmental perturbations not only provides insight into host physiology but is also a useful readout of ecosystem health. Newly metamorphosed northern leopard frogs (Lithobates pipiens), a sentinel species, were collected from agricultural and non-agricultural wetlands exposed to varying concentrations of the herbicide atrazine. Significant effects of certain parasites' abundance and their interaction with atrazine exposure on frog oxidative stress were identified. Specifically, increased protein levels were detected in frogs infected with echinostome metacercariae. In addition, the nematode Oswaldocruzia sp. was significantly associated with increased thiol concentration and catalase activity. Significant parasite × atrazine interactions were observed for atrazine exposure and the abundance of Oswaldocruzia sp. on thiol, as thiol concentrations increased with parasite abundance at low atrazine localities and decreased in high atrazine wetlands. In addition, a significant interaction between the abundances of Oswaldocruzia sp. and gorgoderid trematodes on thiol concentrations was observed. These findings demonstrate that studies of oxidative stress on animals in natural ecosystems should account for the confounding effects of parasitism, particularly for amphibians in agricultural landscapes.
Efficiency of CNT-based rotation transmission nanosystem in water

Carbon nanotubes (CNTs) have been widely used as the motor and rotor in a rotational transmission nanosystem (RTnS), whose function is to transfer the input rotational frequency of the motor into the output frequency of the rotor through motor-rotor interactions. A wide range of techniques has been explored to achieve a CNT-based RTnS with a stable and adjustable transmission. In this work, a CNT-based rotor is partly immersed into a water box and the associated water-rotor interaction leads to effective manipulation of the transmission efficiency of RTnS. Molecular dynamics simulations are performed on this new RTnS to investigate the dynamic response of the rotor and the local flow field near the water-rotor interface. Various parameters, including ambient temperature, tubes’ radii, and volume fractions of water in the box (V f) are examined for their effects on the rotational transmission efficiency. This study offers useful guidelines for the design of stable RTnS with controllable transmission efficiency.
Pharmacologyonline 2 : 102-114 ( 2007 ) Muche and Abdelwuhab 102 DOES INTAKE OF ETHANOL AND KHAT ( CATHA EDULIS FORSK ) AFFECT THE TOTAL NUMBER OF PURKINJE NEURONS IN EARLY POSTNATAL RATS ?

The leaves of khat (Catha edulis) are found to have stimulating and pleasurable effect. The stimulating and insomnial effect is counteracted by ethanol intake. The concomitant use of khat and ethanol ingestion is increasing at an alarming rate, in this country. To study the effect of ethanol and khat on total number of Purkinje neurons and volume of cerebellar cortex, animals of postnatal day 6 were used. They were grouped into control, ethanol, khat and combination of khat and ethanol treated animals each group containing 5 pups. They were deeply anesthetized and sacrificed after 30 days of treatment by perfusion with phosphate buffered formaldehyde. The Cavalier principle and physical dissector methods were used to estimate the volume of cerebellar cortex and numerical density of Purkinje neurons, respectively. The total number of Purkinje neurons was computed from these estimates. It was found that the volume of cerebellar cortex as well as the total number of Purkinje neurons of the ethanol treated animals were significantly less than that of the controls and khat treated animals. No statistically significant difference was observed between the controls and khat treated animals. The numerical density and volume fraction of Purkinje neurons of ethanol treated animals were found to be significantly greater than those of control or khat treated animals. In addition, the numerical density and volume fraction of Purkinje neurons were greater in the khat treated rats than in their corresponding controls, but no statistically significant difference was observed. In conclusion, the study depicted that PND 6 is an extremely vulnerable period during which the rat cerebellar Purkinje neurons are particularly susceptible to the effect of high dose of ethanol. Treatment of khat does not significantly change the above mentioned parameters. On the other hand, combination of khat and ethanol killed all the animals. _________________________________________________________________________
Predictors of Outcome After Mechanical Thrombectomy in Stroke Patients Aged ≥85 Years

ABSTRACT Background: The effectiveness of mechanical thrombectomy (MT) in elderly stroke patients remains debated. We aimed to describe outcomes and their predictors in a cohort of patients aged ≥ 85 years treated with MT. Methods: Data from consecutive patients aged ≥ 85 years undergoing MT at two stroke centers between January 2016 and November 2019 were reviewed. Admission National Institutes of Health Stroke Scale (NIHSS), pre-stroke, and 3-month modified Rankin scale (mRS) were collected. Successful recanalization was defined as modified thrombolysis in cerebral ischemia score ≥ 2b. Good outcome was defined as mRS 0–3 or equal to pre-stroke mRS at 3 months. Results: Of 151 included patients, successful recanalization was achieved in 74.2%. At 3 months, 44.7% of patients had a good outcome and 39% had died. Any intracranial hemorrhage (ICH) and symptomatic ICH occurred in 20.3% and 3.6%, respectively. Logistic regression analysis identiﬁed lower pre-stroke mRS score (adjusted odds ratio [aOR], 0.52; 95% CI, 0.36–0.76), lower admission NIHSS score (aOR, 0.90; 95% CI, 0.83–0.97), successful recanalization (aOR, 3.65; 95% CI, 1.32–10.09), and absence of ICH on follow-up imaging (aOR, 0.42; 95% CI, 0.08–0.75), to be independent predictors of good outcome. Patients with successful recanalization had a higher proportion of good outcome (45.3% vs 34.3%, p = 0.013) and lower mortality at 3 months (35.8% vs 48.6%, p = 0.006) compared to patients with unsuccessful recanalization. Conclusions: Among patients aged ≥ 85 years, successful recanalization with MT is relatively common and associated with better 3-month outcome and lower mortality than failed recanalization. Attempting to achieve recanalization in elderly patients using MT appears reasonable.
Genomic Alterations in PIK3CA-Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors

These findings show that genetic lesions of multiple negative regulators of mTORC1 could limit the efficacy of PI3Kα inhibitors in breast cancer, which may guide patient selection strategies for future clinical trials. PI3Kα inhibitors have shown clinical activity in PIK3CA-mutated estrogen receptor-positive (ER+) patients with breast cancer. Using whole genome CRISPR/Cas9 sgRNA knockout screens, we identified and validated several negative regulators of mTORC1 whose loss confers resistance to PI3Kα inhibition. Among the top candidates were TSC1, TSC2, TBC1D7, AKT1S1, STK11, MARK2, PDE7A, DEPDC5, NPRL2, NPRL3, C12orf66, SZT2, and ITFG2. Loss of these genes invariably results in sustained mTOR signaling under pharmacologic inhibition of the PI3K–AKT pathway. Moreover, resistance could be prevented or overcome by mTOR inhibition, confirming the causative role of sustained mTOR activity in limiting the sensitivity to PI3Kα inhibition. Cumulatively, genomic alterations affecting these genes are identified in about 15% of PIK3CA-mutated breast tumors and appear to be mutually exclusive. This study improves our understanding of the role of mTOR signaling restoration in leading to resistance to PI3Kα inhibition and proposes therapeutic strategies to prevent or revert this resistance. Significance: These findings show that genetic lesions of multiple negative regulators of mTORC1 could limit the efficacy of PI3Kα inhibitors in breast cancer, which may guide patient selection strategies for future clinical trials.
SYNTHESIS OF NANOSTRUCTURED ZNO USING ZINC(II) ISONICOTINATE TETRAHYDRATE AS THE PRECURSOR AND STUDIES ON ITS PHOTOLUMINESCENCE PROPERTIES

*Zinc isonicotinatetetrahydrate, [Zn(NC 5 H 4 -p-CO 2 ) 2 ]·4H 2 O has been employed as a precursor for the synthesis of nanostructured zinc oxide via precipitation-calcination method which is a twostep method. The first step involves room temperature stirring of an alkaline ethanolic solution of the zinc complex along with a suitable amount of NaCl while the second step involves subsequent calcination of the non-crystalline product of the first step reaction at 200°C. Morphology of the as-synthesized ZnO nanoparticles is generally spherical. The semiconductor material was characterized by various physical techniques like XRD, TEM, FESEM, and UV-vis spectroscopy. Optical study suggests that band gap energy of the synthesized oxide is larger than that of the bulk counterpart. The synthesized material exhibits typical photoluminescence behavior.
Site‐Selective Deposition of Nanostructured ZnO Thin Films from Solutions Containing Polyvinylpyrrolidone

When soluble zinc salts are hydrolyzed in water, usually elongated micrometer‐sized zincite crystals are formed. In this study, polyvinylpyrrolidone (PVP) in a methanolic solution is used as an agent to control the morphology of the deposition product. It prevents crystal growth and yields zinc oxide nanocrystals. Thin films consisting of zinc oxide nanocrystals are formed on self‐assembled monolayers (SAMs) of sulfonate‐terminated alkylsiloxanes. Patterned films are deposited after local decomposition of the SAM by UV irradiation. The films fabricated from methanolic solutions containing PVP are particularly smooth, uniform and stable. Their thickness is determined by the deposition time and the molar ratio [PVP]:[Zn2+], so that films of arbitrary thickness and nearly constant roughness can be obtained. The crystal grains are oriented preferentially with 〈001〉 direction perpendicular to the substrate surface. The films show ultraviolet, orange‐red and green‐yellow photoluminescence; the latter is quenched by heat treatment. Based on the obtained experimental results, a deposition mechanism is suggested.