Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparing Peer Evaluations of Teamwork Behavior by K-12 Students versus First-year Engineering Students

The goal of this work-in-process research is to determine the extent to which secondary students in team based courses behave similarly when rating their peers compared to First-Year Engineering (FYE) students. In particular, we are interested in the quality of peer evaluations based on the similarity of the variability or lack thereof in the comparison of peer evaluation ratings. A person’s ability to work effectively in a team or group setting is vital to a college career as well as in a work-life profession and therefore it is often a significant factor in a corporate or government hiring process. Recognizing this need, a number of U.S. undergraduate collegiate STEM programs as well as many K12 instructors, particularly teachers delivering Project Lead The Way (PLTW) courses, use team activity or project-based courses in their curricula. Thousands of undergraduate instructors and K12 teachers also form and manage student teams using online tools including the Team-Maker and the Comprehensive Assessment of Team Member Effectiveness (CATME) tools. CATME contains both scientifically based team formation heuristic tools and a behaviorally anchored peer evaluation instrument that has also been scientifically developed and validated. In spite of the K12 emphasis on the use of teams, the analysis of teamwork behavior and the assessment of effective use of teams in K12 has not seen the same focus as at the collegiate level. When tools such as CATME’s, which was developed for collegiate curriculum, are used, our key question is whether K12 students behave similarly to FYE college students when doing peer evaluations, thereby making the use of assessment tools such as CATME appropriate in K12 contexts.
Spot Detection in Microscopy Images using Convolutional Neural Network with Sliding-Window Approach

Robust spot detection in microscopy image analysis serves as a critical prerequisite in many biomedical applications. Various approaches that automatically detect spots have been proposed to improve the analysis of biological images. In this paper, we propose an approach based on Convolutional Neural Network (convnet) that automatically detects spots using sliding-window approach. In this framework, a supervised CNN is trained to identify spots in image patches. Then, a sliding window is applied on testing images containing multiple spots where each window is sent to a CNN classifier to check if it contains a spot or not. This gives results for multiple windows which are then post-processed to remove overlaps by overlap suppression. The proposed approach was compared to two other popular conv-nets namely, GoogleNet and AlexNet using two types of synthetic images. The experimental results indicate that the proposed methodology provides fast spot detection with precision, recall and F_score values that are comparable with the other state-of-theart pre-trained conv-nets methods. This demonstrates that, rather than training a conv-net from scratch, finetuned pre-trained conv-net models can be used for the task of spot detection.
Climbing the Corporate Ladder: Desired Skills and Successful Psychopaths by Dallas Leigh Hill A Thesis Submitted in Partial Fulfillment of the Requirements for the Degree of Master of Arts in Criminology in The Faculty of Social Science and Humanities Program

Many of the characteristics embodied by successful psychopaths, such as superficial charm, cool decisiveness, and a grandiose self-worth, are often treated synonymously with corporate leadership qualities. Consequently, successful psychopaths are actively being selected for corporate positions as they exemplify the perfect candidate. These successful psychopaths, as corporate leaders and recruiters, increase the probability of systemic psychopathy and whitecollar crime. The current study will provide a deeper understanding of successful psychopaths while exploring the role of the “Westernized” corporation in recruiting successful psychopaths into their businesses through character descriptions in 25 executive career advertisements using Wexler’s (2008) Psychopathic Personality Dimensions and Positively Reinforced Corporate Labels. Results demonstrated that corporations are seeking out characteristics that are synonymous to Factor 1 psychopathic personality traits, which could increase the propensity of successful psychopaths in the workplace. This paper discusses the implications of these findings and identifies some potentially useful approaches for excluding corporate psychopaths from organizations.
DEFERRED TAX MEDIATE THE RELATIONSHIP BETWEEN TAX PLANNING AND EARNINGS MANAGEMENT ?

The objective of this study is to investigate the effect of deferred tax disclosed under the Egyptian Accounting Standard No. 24, income taxes and tax planning on earnings management. In addition, to investigate the role of net deferred tax liabilities as a mediator between tax planning and earnings management. This study employs a sample of 127 firms listed on the Egyptian stock exchange covering the period 2012 to 2018 ending up with 889 observations. Stratified simple random sampling technique was used to select the sample. Path analysis is employed to examine the framework of the study and analyses the indirect effect of tax planning on earnings management. In addition, Ordinary Least Square Regression is employed to calculate discretionary accrual, which is used as a proxy to earnings management. The results suggest that tax planning does not have a significant direct effect on earnings management. However, it has a significant indirect effect on earnings management through net deferred tax liabilities, which in turn has a significant direct effect on earnings management. Findings of this paper may be of interest to financial analysts and standard setters, as they highlight how tax planning and deferred tax liabilities affect the quality of accounting information.
SCHOOL OF ENGINEERING DIVISION OF MECHATRONICS AND INFORMATION TECHNOLOGIES GRADUATE PROGRAMS

We present the analysis of chromaffin vesicles' dynamics during exocytosis. Optical tweezers combined with fluorescence for noninvasive microviscometry in cells and confocal imaging for trajectory analysis were used for this study. By the use of optical tweezers and fluorescent we applied the oscillation method propose by Fischer et al for measuring the intracellular viscoelastic properties in cells. A sinusoidally moving optical trap was used to drive intracellular optical trapped vesicles present in chromaffin cells in order to obtain local information about the viscoelastic liquid surrounding the vesicles. For probing this technique measurement were performed on water, glycerol and PEO, then in cells.
Similarities Amid the Difference : Caregiving Burden and Adaptation Outcomes of Children and Adolescents with Cerebral Palsy and their Parents

Objective. This study had two main objectives: first, to examine the direct and indirect effects, via social support, of caregiving burden on the adaptation outcomes of children/adolescents with cerebral palsy and their parents; and second, to assess the invariance of such models in the clinical vs. the healthy subsamples. Methods. Participants were 210 dyads of children/adolescents and one of their parents (Total N= 420), divided in 93 dyads of children/adolescents with cerebral palsy and 117 dyads of children/adolescents with no medical diagnosis. Data on caregiving burden, social support and adaptation outcomes were obtained through self-report questionnaires. Results. Caregiving burden was linked to parents and their children’s psychological maladjustment and quality of life both directly (except for children’s quality of life) and indirectly through social support. Findings were invariant across clinical and healthy subsamples. Conclusions. Caregiving burden may influence adaptation outcomes of children/adolescents with CP and their parents both directly and via their social support perceptions. These patterns are similar to those observed in typically developing children/adolescents.
Fractal and shape analyses of manganese dendrites on vein quartz

Manganese dendrites are common along joint planes in a quartz vein in Selayang, northern Kuala Lumpur. Individual dendrites mainly range from about 5 cm to 50 cm in length. They have variable shapes that range from simple shape with few branches to complex intricately branched patterns. Dendrites having different patterns may be found together along the same joint plane and some simple dendrites developed into more intricate forms. Digital photographs of dendrites were taken in the field and then converted to single bit images for fractal analysis. The images were also vectorised to measure the perimeter and area of the dendrites as well as the enclosing convex hull. These basic measurements were used to obtain the fractal dimension, lacunarity, PARIS factor, divergent ratio, fractal divergent ratio and fill factor for nine samples, which cover dendrites of various forms and complexities. The fractal dimension of the dendrites measured using box counting algorithm ranges from 1.57 to 1.88. Generally, dendrites with broad and short branches have larger fractal dimension and those that have thin and long branches have smaller fractal dimension. Lacunarity and fill factor also show the same trend, while PARIS factor, divergent ratio and fractal divergent ratio values are higher in complex and intricately branched dendrites. There are dendrites with similar fractal dimension but have dissimilar patterns. At the same fractal dimension, the lacunarity is smaller for more complex and intricately branched dendrites, while the fractal divergent ratio is larger for dendrites with thinner branches. Although the values of both PARIS factor and divergent ratio increase with the increase in the intensity of branching, these parameters cannot be clearly related to the variation in the pattern of dendrites.
Loss-of-function mutation in SCY1 triggers chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana

The secretory (Sec) pathway is one of the most important systems for transporting proteins across the thylakoid membrane into the lumen. Two Arabidopsis genes encoding SecY translocon proteins, designated SCY1 and SCY2, were characterized in this study. Semi-quantitative RT-PCR and histochemical staining β-glucuronidase (GUS) activity reveal that both SCY1 and SCY2 promoters were active in germinating seeds, etiolated cotyledons, and flowers, but not in roots. In particular, the expression of GUS gene driven by the SCY1 promoter was almost undetectable in green leaves, whereas GUS staining controlled by the SCY2 promoter was clearly detected. Moreover, homozygous scy1-1 plants could grow heterotrophically but appeared sensitive to radiation. Further studies show that chloroplasts of scy1-1 were arrested in early developmental stages with fewer thylakoid membranes. Real-time quantitative RT-PCR reveals that a number of nuclear-encoded genes involved in chlorophyll biosynthesis and photosynthesis were substantially down-regulated in the scy1-1 mutant. All these results indicate that the SCY1/2 genes were regulated developmentally and spatially, and a loss-of-function mutation in SCY1 triggered chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana. Additional key words: chloroplast development, gene expression, GUS staining, mutant, RT-qPCR.
Does internet usage activate or inactivate global stock markets ? Exploration by spatial econometrics models ”

Does internet usage activate or inactivate stock markets? On one hand, the vast and quick online information flow forces investors to trade more frequently. On the other hand, information overflow makes them anxious and shying away from decision making, thus hinders trading. This is the first paper to examine the internet effects on stock trading in 30 markets globally by spatial panel models. Empirical results indicate negative internet effects on stock trading. As a whole, internet usages hinder, rather than facilitate, stock trading. In addition, global stock trading demonstrates highly significant spatial correlations; spatial econometric models are more appropriate than OLS models in exploring global stock issues.
The candicidin gene cluster from Streptomyces griseus

Departamento de Ecologı! a, Gene! tica y Microbiologı! a, A; rea de Microbiologı! a, Facultad de Biologı! a, Universidad de Leo! n, 24071 Leo! n, Spain A 205 kb DNA region from Streptomyces griseus IMRU 3570, including the candicidin biosynthetic gene cluster, was cloned and partially sequenced. Analysis of the sequenced DNA led to identification of genes encoding part of a modular polyketide synthase (PKS), genes for thioesterase, macrolactone ring modification, mycosamine biosynthesis and attachment to the macrolide ring, candicidin export and regulatory proteins. It represents the first extensive genetic characterization of an aromatic polyene macrolide antibiotic biosynthetic gene cluster. Of particular interest is the presence of the CanP1 loading domain (the first described as responsible for the activation of an aromatic starter unit) and the polypeptide CanP3 (carrying modules for the formation of five out of seven conjugated double bonds). Disruption of the pabAB gene that encodes the starter unit of candicidin abolished its production [which was restored when exogenous p-aminobenzoic acid (PABA) was supplied to the culture] and resulted in an enhanced production of another antifungal compound that is barely detected in the wild-type.
Platform Dynamism: Sellers’ Responses to Design Change and Implications for Platform Effectiveness

@ @ a「ウエイ。 」エ hッキ@、ッ@ーャ。 エヲッイュ@ッオエ」ッュ・ウ@ゥョエ・イイ・ャ。 エ・@キゥエィ@ウ・ャャ・イウ☂@ウエイ。 エ・ァゥ・ウ_@eクゥウエゥョァ@キッイォ@ッョ@エィ・@ーャ。 エヲッイュMウ・ャャ・イ@イ・ャ。 エゥッョウィゥー 」。 ョ@「・@、ゥカゥ、・、@ゥョエッ@エキッ@ウエイ・。 ュウN@tィ・@ヲゥイウエ@ウエイ・。 ュ@ウィッキウ@エィ。 エ@ーャ。 エヲッイュウ@ュ。 ョ。 ァ・@ウ・ャャ・イ@「・ィ。 カゥッイ@「ケ@」ィ。 ョァゥョァ 、・ウゥァョ@ヲ・。 エオイ・ウ@ウオ」ィ@。 ウ@イ。 ョォゥョァ@。 ャァッイゥエィュウN@tィ・@ウ・」ッョ、@ウエイ・。 ュ@ウィッキウ@エィ。 エ@ウ・ャャ・イウ@。 イ・@」。 ー。 「ャ・@ッヲ@ウエイ。 エ・ァゥコゥョァ 。 イッオョ、@・クゥウエゥョァ@ーャ。 エヲッイュ@」ッョ、ゥエゥッョウN@aョ@ゥューッイエ。 ョエ@ァ。 ー@イ・ュ。 ゥョウZ@キ・@ィ。 カ・@ケ・エ@エッ@ヲッイュ@。 @、ケョ。 ュゥ」@カゥ・キ@ッヲ ーャ。 エヲッイュ@・カッャオエゥッョ@♠@。 ョ@オョ、・イウエ。 ョ、ゥョァ@ッヲ@ィッキ@ウ・ャャ・イウ@ウエイ。 エ・ァゥ」。 ャャケ@イ・ウーッョ、@エッ@。 @ーャ。 エヲッイュ☂ウ@、・ウゥァョ@」ィ。 ョァ・ウ@。 ョ、 ィッキ@エィ・ゥイ@ウエイ。 エ・ァゥ・ウ@ゥョ@エオイョ@。 ヲヲ・」エ@ーャ。 エヲッイュ@ッオエ」ッュ・ウN@uウゥョァ@。 @ウ・ャャ・イMャ・カ・ャ@ー。 ョ・ャ@、。 エ。 ウ・エ@ヲイッュ@aャゥ「。 「。 ☂ウ t。 ッ「。 ッN」ッュL@キ・@ヲゥョ、@エィ。 エ@。 ヲエ・イ@。 ョ@。 ュ「ゥァオッオウ@、・ウゥァョ@」ィ。 ョァ・L@ウ・ャャ・イウ@キゥエィ@ィゥァィ@ウッ」ゥ。 ャ@」。 ーゥエ。 ャ@エ・ョ、@エッ@」ッイイ・」エャケ ゥョエ・イーイ・エ@エィ・@、・ウゥァョ@」ィ。 ョァ・@。 ョ、@イ・ウーッョ、@キゥエィ@。 @ウエイ。 エ・ァケ@エィ。 エ@ゥウ@。 ャゥァョ・、@キゥエィ@エィ・@ーャ。 エヲッイュ☂ウ@ァッ。 ャウN@hッキ・カ・イL ウ・ャャ・イウ@キゥエィ@ャッキ@ウッ」ゥ。 ャ@」。 ーゥエ。 ャ@エ・ョ、@エッ@ゥューャ・ュ・ョエ@。 @ュゥウ。 ャゥァョ・、@ウエイ。 エ・ァケN@iューッイエ。 ョエャケL@エィゥウ@☜。 ャゥァョュ・ョエ@ァ。 ー☝ ー・イウゥウエ・、@ヲッイ@ュッョエィウ@。 ョ、@、・エイ。 」エ・、@ヲイッュ@エィ・@ーャ。 エヲッイュ☂ウ@ッカ・イ。 ャャ@・ヲヲ・」エゥカ・ョ・ウウN@tィゥウ@ウエオ、ケ@ーイゥュ。 イゥャケ@」ッョエイゥ「オエ・ウ@エッ エィ・@ーャ。 エヲッイュ@ャゥエ・イ。 エオイ・@「ケ@、・ュッョウエイ。 エゥョァ@エィ・@、ケョ。 ュゥ」@イ・ャ。 エゥッョウィゥー@「・エキ・・ョ@ウ・ャャ・イウ@。 ョ、@ーャ。 エヲッイュウZ@ーャ。 エヲッイュ ・カッャオエゥッョ@ゥウ@。 @イ・ウオャエ@ッヲ@ョッエ@ッョャケ@ーャ。 エヲッイュ@。 」エゥッョL@「オエ@。 ャウッ@ウ・ャャ・イ@イ・。 」エゥッョN
Antihemolytic activity of Solanum virginianum

Magical properties of herbals are mainly due to the presence of many secondary metabolites of a different property. The herbals provide crude drugs for the common man. The therapeutic potentiality of herbals lies in this phytochemicals that produce marked physiological action on the human body. Ethnopharmacological information is broadly considered an effective method in the discovery of new anti-infective molecules from plants. Many phytochemicals represent adaptive traits that have undergone radical changes during evolution to provide defense in plants against environmental[1] and biotic stress. [2] Defense strategy includes toxicity, antifeedant, microbicidal, antimetastatic, and antinutrients.
A Relation of Distributed Knowledge Classification Using DDC and Time Domain

In this research a relation of knowledge management for Knowledge Mapping is applied using Dewey decimal classification technique to link knowledge hierarchy relation. This paper presents a proposed solution of managing distributed knowledge and represents related knowledge, and the Knowledge Navigator Map based on DDC (Dewey decimal classification) theory. This Knowledge Map also facilitates the integration / coordination knowledge to increase and change the accuracy of the final knowledge. Thus, it can classify a group of knowledge that should be sorted out in the same category. Keyword: Knowledge Management, Dewey decimal classification, Knowledge Relation, Knowledge Map.
Regulatory changes in the alpha-cardiac actin variants H 88 Y and F 90 Δ implicated in early-onset hypertrophic cardiomyopathy

REGULATORY CHANGES IN THE ALPHA-CARDIAC ACTIN VARIANTS H88Y AND F90Δ IMPLICATED IN EARLY-ONSET HYPERTROPHIC CARDIOMYOPATHY Zeeshan Shaikh Advisor: Dr. John F.Dawson University of Guelph, 2018 Cardiovascular disease (CVD) impacts millions of lives affecting 1 in 12 Canadians over the age of 20 between 2012 and 2013. A commonly inherited CVD called Hypertrophic cardiomyopathy (HCM) is defined by an increase in ventricular wall thickness. Little is known about the molecular pathogenesis of HCM apart from its link to mutations in genes encoding sarcomere proteins, including α-cardiac actin (ACTC). My research focuses on the F90Δ and H88Y ACTC variants in early-onset HCM. Studies have shown that myosin activity is largely unchanged with these ACTC variants. I hypothesized that these ACTC variants adversely affect tropomyosin (Tm) regulation, decreasing contractility. Regulated thin filaments (RTFs), and both myosin ATPase assay and an in vitro motility assays were used to generate pCa50 curves. The RTF calcium sensitivity is affected by F90Δ and H88Y variants. These data will contribute to understanding the molecular pathogenesis of earlyonset HCM leading to more specialized treatments.
Knockdown of BRCA 2 enhances cisplatin and cisplatin-induced autophagy in ovarian cancer cells

Clinical implications of the BRCA2 expression level on treatments of ovarian cancer are controversial. Here, we demonstrated that platinum-resistant cancer had a higher percentage of high BRCA2 level (87.5% vs 43.6%, P = 0.001), and that patients with a low BRCA2 level in cancer tissues had longer progression-free survival (with a median time of 28.0 vs 12.0 months, P < 0.001) and platinum-free duration (with a median time of 19.0 vs 5.0 months, P < 0.001) compared with those with a high BRCA2 level. In human ovarian cancer cell lines CAOV-3 and ES-2, cisplatin induced an upregulation of the RAD51 protein, which was inhibited after silencing BRCA2; silencing BRCA2 enhanced the action of cisplatin in vitro and in vivo. Knockdown of BRCA2 promoted cisplatin-induced autophagy. Interestingly, the autophagy blocker chloroquine enhanced cisplatin in BRCA2-silenced cells accompanied by an increase in apoptotic cells, which did not occur in BRCA2-intact cells; chloroquine enhanced the efficacy of cisplatin against BRCA2-silenced CAOV-3 tumors in vivo, with an increase in LC3-II level in tumor tissues. Sensitization of cisplatin was also observed in BRCA2-silenced CAOV-3 cells after inhibiting ATG7, confirming that chloroquine modulated the sensitivity via the autophagy pathway. These data suggest that a low BRCA2 level can predict better platinum sensitivity and prognosis, and that the modulation of autophagy can be a chemosensitizer for certain
Long-term water use efficiency and non-structural carbohydrates of dominant tree species in response to nitrogen and water additions in a warm temperate forest

Nitrogen (N) deposition tends to accompany precipitation in temperate forests, and vegetation productivity is mostly controlled by water and N availability. Many studies showed that tree species response to precipitation or N deposition alone influences, while the N deposition and precipitation interactive effects on the traits of tree physiology, especially in non-structural carbohydrates (NSCs) and long-term water use efficiency (WUE), are still unclear. In this study, we measured carbon stable isotope (δ13C), total soluble sugar and starch content, total phenols, and other physiological traits (e.g., leaf C:N:P stoichiometry, lignin, and cellulose content) of two dominant tree species (Quercus variabilis Blume and Liquidambar formosana Hance) under canopy-simulated N deposition and precipitation addition to analyze the changes of long-term WUE and NSC contents and to explain the response strategies of dominant trees to abiotic environmental changes. This study showed that N deposition decreased the root NSC concentrations of L. formosana and the leaf lignin content of Q. variabilis. The increased precipitation showed a negative effect on specific leaf area (SLA) and a positive effect on leaf WUE of Q. variabilis, while it increased the leaf C and N content and decreased the leaf cellulose content of L. formosana. The nitrogen–water interaction reduced the leaf lignin and total phenol content of Q. variabilis and decreased the leaf total phenol content of L. formosana, but it increased the leaf C and N content of L. formosana. Moreover, the response of L. formosana to the nitrogen–water interaction was greater than that of Q. variabilis, highlighting the differences between the two dominant tree species. The results showed that N deposition and precipitation obviously affected the tree growth strategies by affecting the NSC contents and long-term WUE. Canopy-simulated N deposition and precipitation provide a new insight into the effect of the nitrogen–water interaction on tree growth traits in a temperate forest ecosystem, enabling a better prediction of the response of dominant tree species to global change.
The impact of direct oral anticoagulants on viscoelastic testing – A systematic review

Background In case of bleeding patients and in acute care, the assessment of residual direct oral anticoagulant (DOAC) activity is essential for evaluating the potential impact on hemostasis, especially when a timely decision on urgent surgery or intervention is required. Viscoelastic tests are crucial in a modern goal-directed coagulation management to assess patients’ coagulation status. However, the role of viscoelastic test to detect and quantify residual DOAC plasma levels is controversially discussed. The aim of this review was to systematically summarize the evidence of viscoelastic tests for the assessment of residual DOAC activity. Method PubMed, Embase, Scopus, and the Cochrane Library were searched for original articles investigating the effect of rivaroxaban, apixaban, edoxaban, or dabigatran plasma levels on different viscoelastic tests of the adult population from database inception to December 31, 2021. Results We included 53 studies from which 31 assessed rivaroxaban, 22 apixaban, six edoxaban, and 29 dabigatran. The performance of viscoelastic tests varied across DOACs and assays. DOAC specific assays are more sensitive than unspecific assays. The plasma concentration of rivaroxaban and dabigatran correlates strongly with the ROTEM EXTEM, ClotPro RVV-test or ECA-test clotting time (CT) and TEG 6s anti-factor Xa (AFXa) or direct thrombin inhibitor (DTI) channel reaction time (R). Results of clotting time (CT) and reaction time (R) within the normal range do not reliable exclude relevant residual DOAC plasma levels limiting the clinical utility of viscoelastic assays in this context. Conclusion Viscoelastic test assays can provide fast and essential point-of-care information regarding DOAC activity, especially DOAC specific assays. The identification and quantification of residual DOAC plasma concentration with DOAC unspecific viscoelastic assays are not sensitive enough, compared to recommended anti-Xa activity laboratory measurements. Systematic review registration [https://www.crd. york.ac. uk/prospero/display_record. php? RecordID=320629], identifier [CRD42022320629].