Miracle-dz/UniFAR-FTUs huggingface dataset:
Delayed Development of Head Control and Rolling in Infants With Tracheostomies

Objective: Advances in neonatal care lead to an increased survival rate of critically ill babies. Infantile tracheostomies are not uncommon. However, only a few studies have addressed the effect of infant tracheostomy on early motor function. By comparing the scores of the Gross Motor Function Measure-88 (GMFM) on head control and rolling of infants with and without tracheostomies, the authors aimed to evaluate the effect of infant tracheostomy on early motor development. Methods: Medical records and the GMFM of subjects were retrospectively reviewed. Thirty-three infants with tracheostomies and 132 infants without tracheostomies were matched by gestational age, birth weight, and corrected age when the GMFM was performed using propensity score matching. GMFM scores in head control and rolling in different positions were compared by using generalized estimating equation (GEE). Results: Infants with tracheostomy showed lower values for head control in the supine position and in the pull to sit maneuver in multivariate GEE (p = 0.008, 0.004, respectively). However, the results of head control in a prone position and head lift while the examiner held the thorax showed no difference between the groups. Rolling from prone to supine was delayed in the infants with tracheostomy (p = 0.002), while rolling from supine to prone was not delayed compared to the non-tracheostomized group. More than half (54%) of the tracheostomy group scored better in rolling from a prone to supine position than in head control in supine position, which was a higher ratio compared to the non-tracheostomy group (p = 0.00). Conclusions: Tracheostomy seems to influence early motor development in infants. In particular, head control skills related to neck flexor muscle activation and rolling from prone to supine were delayed. Interventions may be required to facilitate these activities.
Machine Learning Based Unmanned Aerial Vehicle Enabled Fog-Radio Aerial Vehicle Enabled Fog-Radio Access Network and Edge Computing

: The emerging unmanned aerial vehicle (UAV) technology and its applications have become part of the massive Internet of Things (mIoT) ecosystem for future cellular networks. Internet of things (IoT) devices have limited computation capacity and battery life and the cloud is not suitable for offloading IoT tasks due to the distance, latency and high energy con⁃ sumption. Mobile edge computing (MEC) and fog radio access network (F - RAN) together with machine learning algorithms are an emerging approach to solving complex network problems as described above. In this paper, we suggest a new orientation with UAV enabled F - RAN ar⁃ chitecture. This architecture adopts the decentralized deep reinforcement learning (DRL) al⁃ gorithm for edge IoT devices which makes independent decisions to perform computation offloading, resource allocation, and association in the aerial to ground (A2G) network. Addi⁃ tionally, we summarized the works on machine learning approaches for UAV networks and MEC networks, which are related to the suggested architecture and discussed some technical challenges in the smart UAV - IoT, F - RAN 5G and Beyond 5G (6G).
Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer’s Disease

Alzheimer’s disease (AD) is characterized by memory dysfunction, Aβ plaques together with phosphorylated tau-associated neurofibrillary tangles. Unfortunately, the present existing drugs for AD only offer mild symptomatic cure and have more side effects. As such, developments of effective, nontoxic drugs are immediately required for AD therapy. Present study demonstrates a novel role of Chinese medicine prescription Yuan-Hu Zhi Tong (YZT) in treating AD, and it has substantiated the in vivo effectiveness of YZT in two different transgenic mice models of AD, namely P301S tau and 3XTg-AD mice. Oral treatment of YZT significantly ameliorates motor dysfunction as well as promotes the clearance of aggregated tau in P301S tau mice. YZT improves the cognitive function and reduces the insoluble tau aggregates in 3XTg-AD mice model. Furthermore, YZT decreases the insoluble AT8 positive neuron load in both P301S tau and 3XTg-AD mice. Using microarray and the “Connectivity Map” analysis, we determined the YZT-induced changes in expression of signaling molecules and revealed the potential mechanism of action of YZT. YZT might regulate ubiquitin proteasomal system for the degradation of tau aggregates. The research results show that YZT is a potential drug candidate for the therapy of tau pathogenesis and memory decline in AD.
A single-cell atlas of human glioblastoma reveals a single axis of phenotype in tumor-propagating cells

Tumor-propagating glioblastoma (GBM) stem-like cells (GSCs) of the proneural and mesenchymal molecular subtypes have been described. However, it is unknown if these two GSC populations are sufficient to generate the spectrum of cellular heterogeneity observed in GBM. The lineage relationships and niche interactions of GSCs have not been fully elucidated. We perform single-cell RNA-sequencing (scRNA-seq) and matched exome sequencing of human GBMs (12 patients; >37,000 cells) to identify recurrent hierarchies of GSCs and their progeny. We map sequenced cells to tumor-anatomical structures and identify microenvironment interactions using reference atlases and quantitative immunohistochemistry. We find that all GSCs can be described by a single axis of variation, ranging from proneural to mesenchymal. Increasing mesenchymal GSC (mGSC) content, but not proneural GSC (pGSC) content, correlates with significantly inferior survival. All clonal expressed mutations are found in the GSC populations, with a greater representation of mutations found in mGSCs. While pGSCs upregulate markers of cell-cycle progression, mGSCs are largely quiescent and overexpress cytokines mediating the chemotaxis of myeloid-derived suppressor cells. We find mGSCs enriched in hypoxic regions while pGSCs are enriched in the tumor’s invasive edge. We show that varying proportions of mGSCs, pGSCs, their progeny and stromal/immune cells are sufficient to explain the genetic and phenotypic heterogeneity observed in GBM. This study sheds light on a long-standing debate regarding the lineage relationships between GSCs and other glioma cell types.
Data-Driven Neuroendocrine-PID Controller Design for Twin Rotor MIMO System

This paper presents the design of a data-driven neuroendocrine-PID controller based on adaptive safe experimentation dynamics (ASED) method for a twin-rotor MIMO system (TRMS). Neuroendocrine-PID is deemed a compatible controller, often due to its biological-inspired mechanism from a human’s endocrine system that promotes control effectiveness and accuracy. In assessing the robustness of the proposed controller, its parameters were optimized through the ASED method, by tracking both error and input control performances. In particular, the ASED method is a game-theoretic method that randomly perturbs several elements of its controller parameters to search for the optimal controller parameters. Comparison was further made alongside performance of a standard PID controller. Following the simulation conducted, findings with regards to total norm error and total norm input have hereby suggested neuroendocrine-PID as a better controller, following a 13.2% improvement in control accuracy to that of a standard PID controller for TRMS system.
Designing Diverse Agricultural Pastures for Improving Ruminant Production Systems

Pasture-based production systems represent a significant sustainable supplier of animal source foods worldwide. For such systems, mounting evidence highlights the importance of plant diversity on the proper functioning of soils, plants and animals. A diversity of forages and biochemicals –primary and secondary compounds- at appropriate doses and sequences of ingestion, may lead to benefits to the animal and their environment that are greater than grazing monocultures and the isolated effects of single chemicals. Here we review the importance of plant and phytochemical diversity on animal nutrition, welfare, health, and environmental impact while exploring some novel ideas about pasture design and management based on the biochemical complexity of traditional and non-traditional forage sources. Such effort will require an integration and synthesis on the morphology, ecophysiology, and biochemistry of traditional and non-traditional forage species, as well as on the foraging behavior of livestock grazing diverse pasturelands. Thus, the challenge ahead entails selecting the “right” species combination, spatial aggregation, distribution and management of the forage resource such that productivity and stability of plant communities and ecological services provided by grazing are enhanced. We conclude that there is strong experimental support for replacing simple traditional agricultural pastures of reduced phytochemical diversity with multiple arrays of complementary forage species that enable ruminants to select a diet in benefit of their nutrition, health and welfare, whilst reducing the negative environmental impacts caused by livestock production systems.
Spatial and Temporal Evaluation of Ecological Footprint Intensity of Jiangsu Province at the County-Level Scale

Due to the high ecological pressure that exists in the process of rapid economic development in Jiangsu Province, it is necessary to evaluate its ecological footprint intensity (EFI). This article focuses on ecological footprint intensity analysis at the county scale. We used county-level data to evaluate the spatial distributions and temporal trends of the ecological footprint intensity in Jiangsu’s counties from 1995 to 2015. The temporal trends of counties are divided into five types: linear declining type, N-shape type, inverted-N type, U-shape type and inverted-U shape type. It was discovered that the proportions of the carbon footprint intensity were maintained or increased in most counties. Exploratory spatial data analysis shows that there was a certain regularity of the EFI spatial distributions, i.e., a gradient decrease from north to south, and there was a decline in the spatial heterogeneity of EFI in Jiangsu’s counties over time. The global Moran’s index (Moran’s I) and local spatial association index (LISA) are used to analyze both the global and local spatial correlation of EFIs among counties of Jiangsu Province. The high-high and low-low agglomeration effects were the most common, and there were assimilation impacts of counties with strong agglomeration on adjacent units over time. The results implied the utility of differentiated EFI reduction control measures and promotion of low-low agglomeration and suppression of high-high agglomeration in EFI-related ecology policy.
Plant Cadmium Resistance 2 (SaPCR2) Facilitates Cadmium Efflux in the Roots of Hyperaccumulator Sedum alfredii Hance

Hyperaccumulators are the preferred materials for phytoremediation. Sedum alfredii Hance is a cadmium (Cd) hyperaccumulator plant in China, although its detoxification mechanism remains unresolved. In our study, we cloned a gene belonging to the plant cadmium resistance (PCR) family, named SaPCR2, from the hyperaccumulating ecotype (HE) of S. alfredii. Sequence analysis indicated that SaPCR2 contained a cysteine-rich domain highly conserved in the PCR family and played an important role in Cd detoxification. Based on the relative quantitative results, SaPCR2 was highly expressed in the roots of HE S. alfredii, but not the shoots and Cd exposure did not significantly affect SaPCR2 expression. In contrast, the expression level of SaPCR2 was very low in plants of its non-hyperaccumulating ecotype (NHE). The subcellular localization of SaPCR2 in tobacco leaves and yeasts showed that SaPCR2 was localized on the plasma membrane and the expression of the SaPCR2 protein in a Zn/Cd-sensitive yeast Δzrc1 significantly increased its tolerance to Cd stress by decreasing the Cd content in cells. Heterologous expression of SaPCR2 in plants of both Arabidopsis thaliana and NHE S. alfredii significantly reduced the Cd levels in the roots, but not in the shoots. These results suggest that the overexpression of SaPCR2 in plants provides a route for Cd leak out of the root cells and protects the root cells against phytotoxicity of Cd stress. To the best of our knowledge, this is the first study of transporter-mediated root efflux of Cd in hyperaccumulator S. alfredii.
Marker Selection in Multivariate Genomic Prediction Improves Accuracy of Low Heritability Traits

Multivariate analysis using mixed models allows for the exploration of genetic correlations between traits. Additionally, the transition to a genomic based approach is simplified by substituting classic pedigrees with a marker-based relationship matrix. It also enables the investigation of correlated responses to selection, trait integration and modularity in different kinds of populations. This study investigated a strategy for the construction of a marker-based relationship matrix that prioritized markers using Partial Least Squares. The efficiency of this strategy was found to depend on the correlation structure between investigated traits. In terms of accuracy, we found no benefit of this strategy compared with the all-marker-based multivariate model for the primary trait of diameter at breast height (DBH) in a radiata pine (Pinus radiata) population, possibly due to the presence of strong and well-estimated correlation with other highly heritable traits. Conversely, we did see benefit in a shining gum (Eucalyptus nitens) population, where the primary trait had low or only moderate genetic correlation with other low/moderately heritable traits. Marker selection in multivariate analysis can therefore be an efficient strategy to improve prediction accuracy for low heritability traits due to improved precision in poorly estimated low/moderate genetic correlations. Additionally, our study identified the genetic diversity as a factor contributing to the efficiency of marker selection in multivariate approaches due to higher precision of genetic correlation estimates.
Systematic Review of the Impact of Transcranial Direct Current Stimulation on the Neuromechanical Management of Foot and Ankle Physical Performance in Healthy Adults

Objective: This study aims to review existing literature regarding the effects of transcranial direct current stimulation (tDCS) on the physical performances of the foot and ankle of healthy adults and discuss the underlying neurophysiological mechanism through which cortical activities influence the neuromechanical management of the physical performances of the foot and ankle. Methods: This systematic review has followed the recommendations of the Preferred Reporting Items for Systematic reviews and Meta-Analyses. A systematic search was performed on PubMed, EBSCO, and Web of Science. Studies were included according to the Participants, Intervention, Comparison, Outcomes, and Setting inclusion strategy. The risk of bias was assessed through the Cochrane Collaboration tool, and the quality of each study was evaluated through the Physiotherapy Evidence Database (PEDro) scale. Results: The electronic search resulted in 145 studies. Only eight studies were included after screening. The studies performed well in terms of allocation, blinding effectiveness, and selective reporting. Besides, the PEDro scores of all the studies were over six, which indicated that the included studies have high quality. Seven studies reported that tDCS induced remarkable improvements in the physical performances of the foot and ankle, including foot sole vibratory and tactile threshold, toe pinch force, ankle choice reaction time, accuracy index of ankle tracking, and ankle range of motion, compared with sham. Conclusion: The results in these studies demonstrate that tDCS is promising to help improve the physical performances of the foot and ankle. The possible underlying mechanisms are that tDCS can ultimately influence the neural circuitry responsible for the neuromechanical regulation of the foot and ankle and then improve their physical performances. However, the number of studies included was limited and their sample sizes were small; therefore, more researches are highly needed to confirm the findings of the current studies and explore the underlying neuromechanical effects of tDCS.
Phenolic compounds and antioxidant activity of Pecan [Carya illinoinensis (Wangenh.) C. Koch] kernel cake extracts.

El contenido de taninos condensado y fenoles totales de diferentes extractos de tortas de almendra de pecana (eter, acetona, alcohol y agua destilada) fueron estimados y sus actividades antioxidantes fueron evaluadas mediantes los metodos con ABTS, DPPH y el sistema s-caroteno/acido linoleico. Las variaciones de color de la torta de almendra de pecana fueron determinadas mediante analisis instrumental usando el sistema CIE Lab. Los contenidos de fenoles totales, taninos condensados y actividad antioxidante, medida mediante los metodos con ABTS Y DPPH (30 min y 24 h), fueron significativamente mas altos (p < 0.05) con el extracto de acetona (16.4 mg GAE/g; 31.2 mg CE/g; 235.3 µmol TEAC/g and 68.6 and 100.3 mg TEAC/g, respectivamente). El porcentaje de inhibicion de la oxidacion en el sistema s-caroteno/ acido linoleico vario desde 37.9 a 93.1% con el extracto de acetona a 300 ppm, mostrando resultados significativamente superiores. Las muestras con una mayor tendencia a tonos rojos presento los niveles mas altos de taninos condensados.
Identification and Characterization of the Heat-Induced Plastidial Stress Granules Reveal New Insight Into Arabidopsis Stress Response

Plants exhibit different physiological and molecular responses to adverse changes in their environment. One such molecular response is the sequestration of proteins, RNAs, and metabolites into cytoplasmic bodies called stress granules (cSGs). Here we report that, in addition to cSGs, heat stress also induces the formation of SG-like foci (cGs) in the chloroplasts of the model plant Arabidopsis thaliana. Similarly to the cSGs, (i) cpSG assemble rapidly in response to stress and disappear when the stress ceases, (ii) cpSG formation is inhibited by treatment with a translation inhibitor (lincomycin), and (iii) cpSG are composed of a stable core and a fluid outer shell. A previously published protocol for cSG extraction was successfully adapted to isolate cpSG, followed by protein, metabolite, and RNA analysis. Analogously to the cSGs, cpSG sequester proteins essential for SG formation, dynamics, and function, also including RNA-binding proteins with prion-like domain, ATPases and chaperones, and the amino acids proline and glutamic acid. However, the most intriguing observation relates to the cpSG localization of proteins, such as a complete magnesium chelatase complex, which is involved in photosynthetic acclimation to stress. These data suggest that cpSG have a role in plant stress tolerance.
Formulation development and real time stability studies of herbal oral liquids containing natural sweetener.

The present research work supports formulation, development of herbal oral liquids containing Withania somnifera, Asparagus racemosus, Ipoamea purga, Glycyrrhiza glabra, Terminalia chebula, Curcuma zedoria, Tinospora cordiofolia, Cyperus rotundus, Tribulus terrestris, and Sida cardifolia as active ingredients and Stevia rebaudiana as natural sweetener. Standardization was carried out using applicable parameters like color, odor, general appearance, taste, pH, viscosity, surface tension, clarity, specific gravity and other additional parameters like microbial count, TLC profile, HPTLC fingerprint, determination of heavy toxic metal ions and pesticide residue. Sweetness potency was determined by taste evaluation method. Effect of aqueous extract of natural sweetener in the formulation was determined by standardization. Use of this natural sweetener is most convenient, acceptable and palatable in sweet formulations.
The Geography of Connectivity: Trails of Mobile Phone Data

Connectivity between and within places is one of the cornerstones of human geography. However, the data and methodologies used to capture connectivity are limited due to the difficulty in gathering and analysing detailed observations in time and space. Mobile phone data potentially offers a rich and unprecedented source of data, which is exhaustive in time and space closely following movements and partly communication activities of individuals. This paper discusses the state-of-the-art in the analysis of mobile phone data, identifies methodological challenges, elaborates on key findings for geography, and outlines opportunities for future research on the geography of connectivity.
Cyberchondria During the Coronavirus Pandemic: The Effects of Neuroticism and Optimism

Health anxiety during the current coronavirus pandemic can be a serious psychological issue, amplified by the medical uncertainty around this disease and social isolation. As older people are especially at risk of becoming severely ill, it is important to examine the personal factors that make members of this age group more prone to health anxiety. Previous studies indicated that cyberchondria, i.e., the repeated online search for medical information, exacerbates health anxiety. The present research investigated the effect of two opposing traits, optimism and neuroticism, on cyberchondria during the COVID-19 pandemic. The associations of cyberchondria with demographic factors (age, gender, and education) were also examined. A sample of 880 participants, aged 15–67, 65% of whom were female, participated in an online survey. Results show that neuroticism, age, and being female are positively associated with cyberchondria. Optimism was found to be related to cyberchondria, but this effect was qualified by a significant interaction with age. Further analysis revealed that the effect of optimism was significant only in the highest age group. Moreover, among these elderly participants, the psychologically protective influence of optimism against cyberchondria emerged as larger than the opposite effect of neuroticism. This demonstrates the mental benefits of encouraging a positive outlook on the current health crisis and on one’s personal resilience in facing it, especially among the elderly. Conversely, among people who use the Internet as a major source of medical information, those high in neuroticism may be more prone to cyberchondria.
Isolation, characterization, pharmacological evaluation and in silico modeling of bioactive secondary metabolites from Ziziphus oxyphylla a member of Rhamnaceae family

Purpose: To investigate the pharmacological properties of the medicinally active metabolites of Ziziphus oxyphylla. Methods: Compound I-IV were isolated form the root of Ziziphus oxyphylla (compound I = Stigmasterol, II = Betulinic acid, III = 1,2,3 benzene triol and IV = 5-Pentadecanoic acid). Various spectroscopic techniques were used to identify and characterize the isolated compounds. DPPH (2,2-diphenyl-1picrylhydrazyl) and ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) assays were employed to determine the antioxidant potentials of these compounds. The acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition potential of the isolated compounds were also evaluated. Results: Amongst the isolated compounds, compound IV was the most potent antioxidant against DPPH and ABTS free radicals, exhibiting half-maximal concentration (IC50) values of 64 and 65 μg/mL, respectively. All the compounds exhibited good inhibition of acetylcholinesterase and butyrylcholinesterase. However, stigmasterol was more potent than the other isolated compounds, showing IC50 of 85.10 ± 1.45 and 84.81 ± 1.17, respectively, against AChE and BChE. Conclusion: Although, all isolated compounds inhibited the selected free radicals (DPPH and ABTS) and cholinesterases, stigmasterol and 5-penatadecanoic acid were more potent than other two compounds. Thus the former can potentially be used to treat oxidative stress and neurodegenerative diseases.