Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification and validation of a novel zinc finger protein-related gene-based prognostic model for breast cancer

Background Breast invasive carcinoma (BRCA) is a commonly occurring malignant tumor. Zinc finger proteins (ZNFs) constitute the largest transcription factor family in the human genome and play a mechanistic role in many cancers’ development. The prognostic value of ZNFs has yet to be approached systematically for BRCA. Methods We analyzed the data of a training set from The Cancer Genome Atlas (TCGA) database and two validation cohort from GSE20685 and METABRIC datasets, composed of 3,231 BRCA patients. After screening the differentially expressed ZNFs, univariate Cox regression, LASSO, and multiple Cox regression analysis were performed to construct a risk-based predictive model. ESTIMATE algorithm, single-sample gene set enrichment analysis (ssGSEA), and gene set enrichment analyses (GSEA) were utilized to assess the potential relations among the tumor immune microenvironment and ZNFs in BRCA. Results In this study, we profiled ZNF expression in TCGA based BRCA cohort and developed a novel prognostic model based on 14 genes with ZNF relations. This model was composed of high and low-score groups for BRCA classification. Based upon Kaplan-Meier survival curves, risk-status-based prognosis illustrated significant differences. We integrated the 14 ZNF-gene signature with patient clinicopathological data for nomogram construction with accurate 1-, 3-, and 5-overall survival predictive capabilities. We then accessed the Genomics of Drug Sensitivity in Cancer database for therapeutic drug response prediction of signature-defined BRCA patient groupings for our selected TCGA population. The signature also predicts sensitivity to chemotherapeutic and molecular-targeted agents in high- and low-risk patients afflicted with BRCA. Functional analysis suggested JAK STAT, VEGF, MAPK, NOTCH TOLL-like receptor, NOD-like receptor signaling pathways, apoptosis, and cancer-based pathways could be key for ZNF-related BRCA development. Interestingly, based on the results of ESTIMATE, ssGSEA, and GSEA analysis, we elucidated that our ZNF-gene signature had pivotal regulatory effects on the tumor immune microenvironment for BRCA. Conclusion Our findings shed light on the potential contribution of ZNFs to the pathogenesis of BRCA and may inform clinical practice to guide individualized treatment.
Jet‐nozzle method for measuring response times of scalar sensors used in liquids and gases

Response time is a central characteristic of sensors measuring solute concentrations. Knowing the response time of the sensor under realistic conditions is critically important when measuring rapid changes, e.g., oxygen concentration fluctuations for aquatic eddy covariance flux calculations. Response times therefore should be determined under conditions that are similar to those the sensor is exposed to when deployed for the actual measurements. This study introduces a new method for quantifying the response time of mini‐ or microsensors measuring solute concentrations in liquids and gases. The method is based on the rapid switching of the supply of two fluids with different oxygen concentration to the sensor without removing the sensor from the fluid flow. The device uses a jet nozzle moved by electromagnetic actuators, and the switching of the calibration fluids is monitored by a reference sensor with a response time < 0.001 s. The functionality of the device is demonstrated for a fast oxygen optode system that consisted of a fiber minioptode connected to an oxygen meter that was read by a data logger. With the setup described here, the method permits reproducible response time measurements with a resolution of 0.01 s ± 0.001 s (SD, n = 60). With this technique, the response time characterization of aquatic sensors can be standardized.
PRBM_A_256228 1429..1436

1Department of Medicine, Northwell Health Cancer Institute, Lenox Hill Hospital, New York, NY, USA; 2Department of Medicine, Section of Hematology/Oncology, University of Chicago, MacLean Center for Clinical Medical Ethics, and the Cancer Research Center, Chicago, IL, USA Abstract: Burnout and emotional exhaustion in frontline healthcare workers and their implications for the health of patients, individual clinicians, and organizations are increasingly described among various healthcare settings. Yet therapeutic strategies to address burnout and other work-related conditions are outpaced by innumerable descriptions of burnout prevalence across healthcare disciplines. This review provides a framework that should be helpful in beginning the process of addressing burnout and its related conditions. It begins with an elucidation of key inter-related concepts of work-related conditions that should be considered in the differential diagnosis along with other mental health conditions that are concomitantly elevated in healthcare clinicians (eg, depression and substance abuse) but require a different approach to treatment. Factors that lead to increased resilience, engagement, and thriving in clinical workplaces are considered. While strategies are dichotomized between organizational level interventions and individual or personal interventions to address burnout, the idea of identifying and addressing root causes of burnout and related conditions is highlighted. The efficacy and feasibility of interventions that incorporate mindfulness-based stress reduction, cognitive behavioral strategies, meaning-centered therapy, and compassion training are highlighted as interventions with proven efficacy and durability that should be considered based on work-related stressors and appeal to clinicians.
Decision Drivers for Search Engine Usage – The Mediating and Moderating Role of Lock-in Effects

This study analyzes the central factors influencing the satisfaction and future use of search engines. It examines the influence of technological lock-in effects (e. g. operating systems / browsers providing pre-settings), as well as basic product- and brand-related factors (e. g. search results, user experience, brand image). Data was collected via a quantitative online survey in Germany, which resulted in 236 respondents providing statements about their most recently used search engine. The data shows that all independent variables have a strong impact on the satisfaction with a search engine as well as future usage and explain a lot of the variance of the dependent variables. The satisfaction with the core product has the strongest impact, followed by brand-related aspects and user experience. The results also show an impact of a search engine preset in the browser effects that influences the role of brand and the evaluation of different product characteristics.
“You Can Make a Difference”: Teachers’ Agency in Addressing Social Differences in the Student Body

Teachers are key players in transforming the education system (van der Heijden et al., 2015). They shape educational processes, influence school policies, and make day‐to‐day decisions that have a direct effect on students (Vähäsantanen, 2015). Yet we currently know very little about whether they can contribute to the creation of social equality of opportunity. This article focuses by way of example on the experiences and interpretative schemes of teachers in Germany, as the country is known for its highly selective school system. It draws on data from an exploratory study based on 20 narrative interviews (Rosenthal, 2018) with schoolteachers at three comprehensive schools in East and West Germany, which were selected because comprehensive schools in Germany see themselves as a more equal‐opportunity form of education. The article begins by identifying four types of teacher action orientations in addressing the social differences of schoolchildren. Unexpectedly, only a few teachers exhibited a socially conscious inclination to act—for example, by providing targeted support to schoolchildren from socially disadvantaged households. In the second step, by comparing teacher biographies, school environments, and historical imprints, the article attempts to identify certain conditions under which teachers perceive themselves as responsible for addressing social differences among students. Beyond illustrating the interplay of biographical experiences and school culture, the study’s east–west contextualization opens up a new perspective for examining the lingering implications of the German half‐day schooling model even after the introduction of all‐day schooling in 2003. One possible conclusion is that the transformation of the German school system from a half‐day to an all‐day model has not taken the tasks of teachers into account, which, as this article points out, would be important in making them aware of schoolchildren’s different social backgrounds and their effects on achievement.
Nursing diagnoses/outcomes and interventions for patients with COVID-19: a retrospective documentary study

Submission: 03/24/2021 Approved: 08/04/2021 ABSTRACT Objective: To elaborate Nursing Diagnoses/Outcomes and Interventions using the International Classification for Nursing Practice in patients with coronavirus infection. Method: An exploratory, descriptive, retrospective and documentary study, developed in emergency care units in the municipality of João Pessoa Paraíba. The sample consisted of 187 medical records and data collection was carried out between June and August 2020. Data analysis was performed using descriptive statistics, mean, range and standard deviation. Result: A total of 12 Nursing Diagnoses/Outcomes (Dyspnea, Fever, Cough, Muscle Pain, Headache, Diarrhea, Impaired Smell, Impaired Taste, Lack of Appetite, Impaired Swallowing, Chest Pain and Vomiting) and 36 Nursing Interventions targeted at patients affected by coronavirus were identified. Conclusion: The identification of Nursing Diagnoses/Outcomes and Interventions is indispensable to support care, especially in the current scenario of the COVID-19 pandemic, contributing to the operationalization of the Nursing Process. DESCRIPTORS: Nursing; Nursing Process; Nursing Diagnosis; Standardized Terminology in Nursing; Coronavirus Infections.
PGPM_A_325788 1193..1203

1Department of Pharmacy, Xinagya Hospital, Central South University, Changsha, 410008, People’s Republic of China; 2Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital, Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, 410013, People’s Republic of China; 3Hunan Clinical Research Center in Gynecologic Cancer, Hunan Cancer Hospital, Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, 410013, People’s Republic of China; 4National Institution of Drug Clinical Trial, Xiangya Hospital, Central South University, Changsha, 410008, People’s Republic of China Purpose: To investigate the relationships between Wnt1 inducible signaling pathway protein 1 (WISP1) polymorphisms and the prognosis of platinum-based chemotherapy in lung cancer patients. Patients and Methods: A total of 363 lung cancer patients were recruited in this study. All of them received at least two cycles of platinum-based chemotherapy. We used unconditional logistic regression analysis to assess the associations of 39 single nucleotide polymorphisms in WISP1 gene with platinum-based chemotherapy prognosis. Results: The results indicated that patients carried rs2929973 GT or GG genotypes had increased risk of disease progression (HR = 0.712, 95% CI = 0.553–0.916, P = 0.015). Patients with rs2977551 TT genotype had a significantly decreased risk of progression-free survival than patients carrying CT or CC genotype (HR = 0.723, 95% CI = 0.561–0.932, P = 0.032) and overall survival (HR = 0.725, 95% CI = 0.552–0.913, P = 0.045). For rs2977549, patients carrying TT genotype had a significantly longer progression-free survival than patients with CC or CT genotypes (HR = 0.708, 95% CI = 0.550–0.912, P = 0.017). Among of them, rs16904853, rs10956697, rs2929965, rs2929973, rs7828685, rs2977551 and rs2977549 were related to progression-free survival, and rs10956697 and rs2977551 were related to overall survival in subgroup analyses, respectively. Conclusion: WISP1 rs2929973, rs2977551 and rs2977549 may be contributed to a potential candidate biomarker for prediction of platinum-based chemotherapy prognosis in lung cancer patients.
First report on detection of Babesia spp. in confiscated Sunda pangolins (Manis javanica) in Thailand

Abstract Background and Aim: The Sunda pangolin (Manis javanica) is on the International Union for Conservation of Nature Red List of Threatened Species (critically endangered) due to high levels of illegal trafficking for its products. Thailand is one of the habitats of this species, and it has become the main hub for its illegal trafficking. Rehabilitating these captive pangolins and reintroducing them back to the wild are challenging due to the limited knowledge on their diet, management, and diseases. Hemoparasites, including Babesia spp. , can cause important protozoal infections in both domestic and wild animals, resulting in the failure of rehabilitation and conservation programs. However, Babesia spp. has not been reported in pangolins. The aim of the study was to determine the prevalence of Babesia spp. in the Sunda pangolin of Thailand. Materials and Methods: A total of 128 confiscated Sunda pangolins from across different regions in Thailand were investigated. These pangolins had been admitted to a regional Wildlife Quarantine Center for rehabilitation before release in the forest. Routine physical examinations were conducted on the animals. We collected blood samples from each pangolin for hematological analysis and to detect Babesia spp. using polymerase chain reaction (PCR) targeting the partial 18s rRNA gene. Results: Babesia-specific PCR detected 53 animals (41.4%) that were positive for Babesia spp. Blood smears were obtained from the positive samples and investigated under a light microscope to observe for trophozoites of Babesia spp. Examination of 40 PCR-positive and -negative samples found no significant differences between the hematological parameters of Babesia-positive and Babesia-negative samples. Eight PCR-positive samples were randomly selected and their DNA was sequenced. Seven and one of sequences match uncharacterized Babesia spp. with 100% and 99.2% similarity, respectively. Phylogenetic analysis demonstrated that our samples form a unique monophyletic clade along with other Babesia spp. detected in the wild. This clade is clearly separated from other Babesia spp. from small carnivores, ruminants, and rats. Conclusion: Our results provide evidence of infection of Sunda pangolins in Thailand by Babesia spp. These pangolins originated from different regions and had not lived together before blood collection. Thus, we suggest that the uncharacterized Babesia spp. found in this study constitute a new group of pangolin-specific Babesia spp. The prevalence of the uncharacterized Babesia spp. was not correlated to pangolin health. Further studies are required to characterize the genomes and phenotypes, including the morphology and pathogenicity of these protozoa. Such information will be helpful for the conservation and health management of the Sunda pangolin.
DUAL BAND CIRCULARLY POLARIZED MODIFIED Ψ-SHAPE MICROSTRIP ANTENNA

Single patch designs of a microstrip antenna with a U-slot or a pair of rectangular slots (E-shape) provide a single band circularly polarized response, and hence they are not useful in frequency and polarization agile applications. In this paper, a modified design of a Ψ-shape microstrip antenna is proposed for dual band and dual sense circularly polarized response. Use of unequal length rectangular slots in the modified patch optimizes the inter-spacing between the modified TM21 and TM22 resonant modes, surface current distributions and impedance levels at them to yield dual band circularly polarized response. An impedance bandwidth of 1992MHz (37.05%) is obtained which completely covers the axial ratio bandwidth of 11.84 and 5.67%, in the two bands with a frequency ratio of 1.3 in between them, thereby satisfying the requirements of frequency agile systems. Over the impedance and axial ratio bandwidth, the antenna exhibits nearly broadside radiation pattern with a gain of around 7 dBi. A design methodology based on the simple parametric formulation is presented, which helps in realizing a similar antenna in the specific frequency band. The proposed antenna can find applications in frequency and polarization agile systems where the signal loss due to the interference and jamming can be reduced.
CLEP_A_322779 813..823

1Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Science, NTNU – Norwegian University of Science and Technology, Trondheim, Norway; 2Department of Stroke, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; 3Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands; 4Department of Clinical Pharmacology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; 5Department of Clinical and Molecular Medicine, NTNU – Norwegian University of Science and Technology, Trondheim, Norway; 6Department of Mental Health, Faculty of Medicine and Health Sciences, NTNU – Norwegian University of Science and Technology, Trondheim, Norway; 7Department of Geriatrics, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway Purpose: Suboptimal secondary prevention in patients with stroke causes a remaining cardiovascular risk desirable to reduce. We have validated a prognostic model for secondary preventive settings and estimated future cardiovascular risk and theoretical benefit of reaching guideline recommended risk factor targets. Patients and Methods: The SMART-REACH (Secondary Manifestations of Arterial Disease-Reduction of Atherothrombosis for Continued Health) model for 10-year and lifetime risk of cardiovascular events was applied to 465 patients in the Norwegian Cognitive Impairment After Stroke (Nor-COAST) study, a multicenter observational study with twoyear follow-up by linkage to national registries for cardiovascular disease and mortality. The residual risk when reaching recommended targets for blood pressure, low-density lipoprotein cholesterol, smoking cessation and antithrombotics was estimated. Results: In total, 11.2% had a new event. Calibration plots showed adequate agreement between estimated and observed 2-year prognosis (C-statistics 0.63, 95% confidence interval 0.55–0.71). Median estimated 10-year risk of recurrent cardiovascular events was 42% (Interquartile range (IQR) 32–54%) and could be reduced to 32% by optimal guidelinebased therapy. The corresponding numbers for lifetime risk were 70% (IQR 63–76%) and 61%. We estimated an overall median gain of 1.4 (IQR 0.2–3.4) event-free life years if guideline targets were met. Conclusion: Secondary prevention was suboptimal and residual risk remains elevated even after optimization according to current guidelines. Considerable interindividual variation in risk exists, with a corresponding variation in benefit from intensification of treatment. The SMART-REACH model can be used to identify patients with the largest benefit from more intensive treatment and follow-up.
Chemical and biological additives in high moisture triticale silages: Nutritional value and ingestive behavior in sheep

El ensilaje de triticale de grano con alto contenido de humedad es una excelente opcion para las dietas de rumiantes. Sin embargo, falta informacion sobre el control de perdidas durante el proceso de fermentacion. Se hizo una evaluacion sobre los efectos de los aditivos quimicos y biologicos a ensilajes de triticale de alta humedad en la composicion quimica-bromatologica, la estabilidad aerobica, la digestibilidad in vivo y el comportamiento de ingesta en ovinos. Se evaluaron cuatro tratamientos: ensilaje de triticale sin aditivo (control); ensilaje con un inoculante enzimatico-bacteriano; ensilaje con 0.5% de urea en materia natural; y ensilaje con benzoato de sodio al 1.5% en materia natural. El comportamiento de ingesta se evaluo con cuatro ovejas macho en jaulas metabolicas. La adicion de urea como aditivo proporciono un aumento en el contenido de la proteina cruda (189.7 g kg MS -1 ) y el nitrogeno amoniacal (106.2 g kg MS -1 ), pero no afecto la digestibilidad (699.6 g kg MS -1 en tratamiento con urea, promedio = 687.5 g kg MS -1 ) ni el comportamiento de ingesta. El consumo de fibra aumento con la adicion del aditivo enzimatico-bacteriano (431.87 vs 388.06 g d -1 fibra detergente neutra en el control). Todos los aditivos ayudaron a preservar el contenido de proteina cruda despues de la apertura del silo, pero ninguno interfirio en el tiempo de estabilidad aerobica del ensilado.
Solar Radiation Effect on a Magneto Nanofluid Flow in a Porous Medium with Chemically Reactive Species

Abstract The combined impact of solar radiation, chemical reaction, Joule heating, viscous dissipation and magnetic field on flow of an electrically conducting nanofluid over a convectively heated stretching sheet embedded in a saturated porous medium is simulated. By using appropriate similarity transformation, the governing nonlinear equations are converted into ODEs and numerical shooting technique with (RK45) method is employed to tackle the problem. The effects of various thermo-physical parameters on the entire flow structure with heat and mass transfer are presented graphically and discussed quantitatively. Special cases of our results are benchmarked with some of those obtained earlier in the literature and are found to be in excellent agreement. It is found that both the temperature and surface concentration gradients are increasing functions of the non-Darcy porous medium parameter. One describing result is the incident solar radiation absorption and its transmission into the working nanofluid by convection.
University of São Paulo “Luiz de Queiroz” College of Agriculture Phosphate sources derived from wastewater and sewage sludge: agronomic potential

Phosphate sources derived from wastewater and sewage sludge: agronomic potential Phosphorus (P) is a nutrient essential for energy metabolism and DNA/RNA production in plants. In Brazil, high amounts of P fertilizers are applied onto agricultural fields every year to supply plants demand, creating an economic, environmental and supply chain risk scenario. To overcome those issues, phosphate sources recycled from wastewaters and sewage sludge merge as an alternative to conventional fertilizers, due to their agronomic potential use and renewable origins, reducing environmental impact while contributing to sustainable agriculture and circular economy. Struvite and hazenite are minerals recovered via chemical precipitation from wastewaters, while ashdec can be obtained through thermochemical treatment of sewage sludge ashes. Low water-solubility and late release, more aligned with plants demand, are common characteristics of these recycled fertilizers, what could improve the efficiency of P fertilization. Here, we evaluated the solubilization of struvite, hazenite ashdec and triple superphosphate (TSP), their P release dynamics and their impact on the solution pH and on soil P fractions through an incubation leaching columns experiment. We also assessed their agronomic potential and efficiency compared to TSP (chosen conventional source) through a greenhouse trial for two 90 days cycles of sugarcane (Saccharum spp.) under those phosphate sources and three P doses (30, 60 and 90 mg kg). Dry mass yield (DMY), biometric parameters, nutrient uptake and soil P fractions were analyzed for each harvest. Our findings showed that while the recycled sources are less water-soluble and promote late P release, solubilizing less P than TSP in the initial period, plants were able to improve P utilization from these sources, since struvite (both harvests) and hazenite (first cycle) outperformed, while ashdec was comparable to TSP in DMY and P uptake. In the first 90 d, all three recycled sources showed higher soil labile P levels than TSP, which was the only source increasing the non-labile pool by the end.