Miracle-dz/UniFAR-FTUs huggingface dataset:
A Brief Review of Robotic Machining

Abstract The approach of this paper was to analyze the technical borders of industrial robots and to provide an overview of current technology, technical constraints and the potential types of future research suggestion concerning robotic machining. These complex automation machines used in manufacturing processes are an emerging chapter of industrial engineering that contribute to automatically performing operation in subtractive manufacturing and sheet metal forming processes. Compared with CNC machines which have shape limitations and have the restricted working area, the industrial robot is a flexible, cost-saving alternative.
Comparative dissolution studies on granules with acetaminophen and caffeine using the basket and paddle methods with simultaneous spectrophotometric determination of active substances

Abstract Acetaminophen and caffeine, popular therapeutic substances used to relieve pain or alleviate the symptoms of cold. The aims of the study were the comparison of granules, in terms of dissolution rate and moreover the development of spectrophotometric method to the simultaneous determination of both active pharmaceutical ingredients (APIs) in granules. The granules were tested by two pharmacopoeial methods of dissolution for solid dosage forms, and the dissolution profiles for each formulation were compared. A method of simultaneous determination of two medicinal substances by the double calibration method using derivative spectrophotometry was used. Considering the dissolution process carried out in the paddle apparatus, it was shown that more than 80% of acetaminophen and caffeine were released from each of the preparations in a clearly shorter time than 10 minutes. Carrying out the basket test, substances dissolved gradually, much slower than in the paddle method. The time required to release 80% of both active substances from majority of tested preparations was from 30 to 45 minutes. Application of the first derivative spectrophotometric method allows simultaneous determination of acetaminophen and caffeine in the mixture, without the need to separate them first.
Youth Start Social Entrepreneurship Program for Kids: Portuguese UKIDS-Case Study

Abstract Today’s society has valued entrepreneurship in various sectors of personal and professional life, but the school seems to forget this reality. Aware of this fact, the Portuguese Ministry of Education has created a program, from early childhood education to basic and secondary education, to develop the concept of social entrepreneurship in schools. The Porto Polytechnic Higher School of Education, as an educator of teachers and teachers of the First and Second cycle of Basic Education, joined the European UKIDS project to integrate this theme in the initial and continuous teacher training. In this article we will analyze the data obtained from a UKIDS Portuguese Partner School in the context of continuing teacher education and present some conclusions. The qualitative methodology used allowed us to conclude that the UKIDS project enhanced the valorization of individual capacities, such as creativity, self-confidence, the power of argumentation, as well as the construction of social competences, in interpersonal and group relationships, which are crucial in the formation of a child’s personality in the basic school learning process.
Challenges in technology of bilayer and multi-layer tablets: a mini-review

Abstract Bilayer and multi-layer tablets are enjoying growing popularity among original drug and generic product manufacturers. Multi-layer tablets have many key benefits compared to classic immediate-release tablets. The use of such solid oral dosage forms simplifies dosing regimens in combination therapy, and thus improves patient compliance. However, the technology of multilayer tablets is demanding and requires precise choice of excipients and production parameters with regard to each technological step. The main benefits of multi-layer tablets, certain aspects of their production and the challenges encountered during the compression process are reviewed in this paper.
Numerical Modelling of the Subsoil Zone between Stone Columns

Abstract Designing the improvement of soil using stone columns is usually based on simplified analytical or numerical models. Stone columns installed using a vibro-replacement technique can cause radial displacement of the original soil. It can cause radial compaction of the soil and increase the values of the strength and deformation properties, which are usually ignored in a practical design. The paper presents the results of a numerical analysis of a road embankment based on subsoil improved using stone columns. The changes in the properties of the original subsoil compacted by stone columns were analysed and taken into consideration in the models. The results showed that a model with homogenization of the subsoil and a model with stone columns transferred to continuous walls show similar results of the final settlement as well as the consolidation times. The differences between the values computed and measured were about 28 - 36 %. Taking into account the compacting effect of the original subsoil, the model with stone columns transferred to continuous walls allowed for the determination of more precise results when the difference between the values computed and measured was about 10 %.
The Best of Both Worlds: Mitigating Trade-offs Between Accuracy and User Burden in Capturing Mobile App Privacy Preferences

Abstract In today’s data-centric economy, data flows are increasingly diverse and complex. This is best exemplified by mobile apps, which are given access to an increasing number of sensitive APIs. Mobile operating systems have attempted to balance the introduction of sensitive APIs with a growing collection of permission settings, which users can grant or deny. The challenge is that the number of settings has become unmanageable. Yet research also shows that existing settings continue to fall short when it comes to accurately capturing people’s privacy preferences. An example is the inability to control mobile app permissions based on the purpose for which an app is requesting access to sensitive data. In short, while users are already overwhelmed, accurately capturing their privacy preferences would require the introduction of an even greater number of settings. A promising approach to mitigating this trade-off lies in using machine learning to generate setting recommendations or bundle some settings. This article is the first of its kind to offer a quantitative assessment of how machine learning can help mitigate this trade-off, focusing on mobile app permissions. Results suggest that it is indeed possible to more accurately capture people’s privacy preferences while also reducing user burden.
Measurements of Galvanic Skin Response on Subjects Affected by Stress

Abstract The aim of the present paper is to study the Galvanic Skin Response (GSR) level on subjects affected by stress. The device that we have used, connects to the people by finger electrodes to record GSR. The purpose was to find statistical differences between the activities (mental task, walking, sitting and to fill out a survey about their lives) and their stress level. During the experiment, it was found that the survey caused the source of high stress and increasing skin conductance was caused by sweat secretion (mental, physical activity). Is needed to work of collecting data from more subjects because GSR is depended on human behaviour, is variable upon many factors (their eating habits, their emotional state, their gender, their relationship with family, etc) and we need to build a substantial data set for a valid research.
Analysis of Internally Generated Goodwill Indicators: A Case Study of the Slovak Republic

Abstract Background and purpose: Knowing key indicators of goodwill value can contribute to its effective management and growth of the market value of the enterprise. The purpose of this research is to identify individual goodwill indicators. The paper aim is to obtain potential indicators of enterprise goodwill under the conditions of the Slovak Republic. Design/Methodology/Approach: Paper data included 11,483 financial statements of Slovak enterprises in 2017. The value of residual enterprise income represents the value of goodwill. Input data for the identification of goodwill indicators represented 15 financial-economic variables. Outliers in data were searched and removed through an interquartile range. Multicollinearity among input variables, by the coefficient of determination and variance inflation factor, was also analysed. A statistically significant correlation between goodwill and its potential indicator were tested by the significance test of the Pearson correlation coefficient and correlation matrixes. Results: Research results reveal the existence of a statistically significant correlation between goodwill and 8 input variables, which represent its potential vital indicators. Conclusion: Paper findings bring new possibilities for goodwill management, which may create an essential competitive advantage of a company. For the scientific community, the findings represent sources of potential goodwill indicators which can be used for the creation of the new model of goodwill valuation in future research.
Safety of Janus Kinase Inhibitors in Patients with Inflammatory Bowel Diseases or Other Immune-mediated Diseases: a Systematic Review and Meta-Analysis.

BACKGROUND & AIMS Inhibitors of Janus kinases (JAKs) are being developed for treatment of inflammatory bowel diseases and other immune-mediated diseases. Tofacitinib is effective in treatment of ulcerative colitis, but there are safety concerns. We performed a systematic review and meta-analysis to investigate the safety profile of tofacitinib, upadacitinib, filgotinib, and baricitinib in patients with rheumatoid arthritis, inflammatory bowel diseases, psoriasis, or ankylosing spondylitis. METHODS We searched the MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials from January 1, 1990 through July 1, 2019. We performed a manual review of conference databases from 2012 through 2018. The primary outcome was incidence rates of adverse events (AEs) and serious AEs. We also estimated incidence rates of serious infections, herpes zoster infection, non-melanoma skin cancer, other malignancies, major cardiovascular events, venous thromboembolism, and mortality. We performed a meta-analysis, which included controlled studies, to assess the relative risk of these events. RESULTS We identified 973 studies; of these 82 were included in the final analysis, comprising 66159 patients with immune-mediated diseases who were exposed to a JAK inhibitor. Two-thirds of the included studies were randomized controlled trials. The incidence rate of AEs was 42.65 per 100 person-years and of and serious AEs was 9.88 per 100 person-years. Incidence rates of serious infections, herpes zoster infection, malignancy, and major cardiovascular events were 2.81 per 100 person-years, 2.67 per 100 person-years, 0.89 per 100 person-years, and 0.48 per 100 person-years, respectively. Mortality was not increased in patients treated with JAK inhibitors compared to patients given placebo or active comparator (relative risk 0.72; 95% CI, 0.40-1.28). The meta-analysis showed a significant increase in risk of herpes zoster infection among patients who received JAK inhibitors (relative risk 1.57; 95% CI, 1.04-2.37). CONCLUSIONS In a systematic review and meta-analysis, we found an increased risk of herpes zoster infection among patients with immune-mediated diseases treated with JAK inhibitors. All other AEs were not increased among patients treated with JAK inhibitors.
Stillbirth and subsequent pregnancy outcome – a cohort from a large tertiary referral hospital

Abstract Objectives This study aimed to assess pregnancy and delivery outcomes in women with a history of stillbirth in a large tertiary referral hospital. Methods This was a retrospective study from Helsinki University Hospital, Finland. The cohort comprised 214 antepartum singleton stillbirths in the period 2003–2015 (case group). Of these, 154 delivered by the end of 2017. Adverse pregnancy outcomes were compared to those in singleton pregnancies of parous women in Finland from the Finnish Medical Birth Register (reference group). Results The rates of adverse pregnancy outcomes were higher among case women for preeclampsia (3.3 vs. 0.9%, P = 0.002), preterm birth (8.5 vs. 3.9%, P = 0.004), small-for-gestational-age (SGA) children (7.8 vs. 2.2%, P < 0.001) and stillbirth (2.7 vs. 0.3%, P < 0.001). There were four preterm recurrent stillbirths. Induction of labor was more common among case women than parous women in the reference group (49.4 vs. 18.3%, P < 0.001). Duration of pregnancy was shorter among case women (38.29 ± 3.20 vs. 39.27 ± 2.52, P < 0.001), and mean birth weight was lower among newborns of the case women (3274 ± 770 vs. 3491 ± 674 g, P < 0.001). Conclusion Although the rates for adverse pregnancy outcomes were higher compared to the parous background population, the overall probability of a favorable outcome was high. The risk of recurrent premature stillbirth in our cohort was higher than that for parous women in general during the study period. No recurrent term stillbirths occurred, however.
CMAR_A_196655 2795..2802

Yanqing Li Yan Jiao Zhuo Fu Zhangping Luo Jing Su Yang Li 1Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, People’s Republic of China; 2Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, People’s Republic of China; 3Department of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, People’s Republic of China; 4Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, People’s Republic of China Purpose: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the clinic all over the world, which has become a public health challenge. The T/N/M staging system plays a core role in HCC prognosis. However, it cannot precisely stratify the risk of HCC prognosis. MiR-454-3p plays an important role in the progression of tumors. Therefore, we need to develop more reliable prognostic markers for HCC patients which can focus on miR-454-3p. Methods: We used Chi-square and Fisher exact tests to assess correlations between miR454-3p expression and clinical parameters in liver cancer patients from The Cancer Genome Atlas database (TCGA). Then, Cox regression analysis, Kaplan-Meier curve, and log-rank test were used to compare the difference of survival between the high-expression group and low-expression group, and P value was included. Finally, we used TCGA data set to carry out gene enrichment analysis. Results: In this research, the expression of miR-454-3p increased in HCC and was associated with patient survival, G3/G4 staging, III/IV staging and T staging. Higher miR-454-3p expressed patients had shorter survival time. Besides, mitotic spindle, G2M checkpoint, and E2F targets were differentially enriched in miR-454-3p high-expression phenotype by Gene set enrichment analysis. Conclusion: Overexpression of miR-454-3p may be a significant and independent predictor of poor prognosis in HCC patients.
Influence of auxiliary gas on silicon carbide machining by femtosecond laser

A contrast experimental study is reported to characterize the femtosecond (FS) laser grooving process for silicon carbide (SiC) with auxiliary gas and ambient air. The effect of laser powers on the characteristics of grooves is analyzed in this paper. Machining in the presence of auxiliary gas is beneficial to the debris ejection from the grooves. The experiment showed that high quality grooves can be obtained on SiC wafers with auxiliary gas, which demonstrated the potential for this machining technique.
Laboratory strength assessment of athletes

V V Field tesls for the asses.smeni of progress in the development ttf strength qualities have Ihe advantage of being event specific. However, their tlrawback lies in their inability to detennine which . specific qualily has Influenced any improvement . shown, be it techniqtie, maximum slrength. speed . strength or reactive strength. The aulhor describes an a.sse. s.smenl system developeti ai the Australian Institute of Spon. which is not only . specific to the nature ofthe evenl hut is also able lo differeiUiate between the various . strength qualilies. The System Is called the Strength Qtuililies As.sessinent Test' (S.Q.A.T.). ll is designed lo assess the strength ijualities of the leg exiensor muscles, a.ssuming that these have the greatest infiuence on the movements of running and jiunping.
OTT_A_228301 11305..11311

Shen Chen 1 Yayi He 1 Juan Liu Xiaoxia Chen Jia Yu Wei Li Bin Chen Chenglong Sun Caicun Zhou 1Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, People’s Republic of China; 2Department of Respiratory, Shanghai Fourth People Hospital, Shanghai, People’s Republic of China; 3Department of Medical Oncology, Anhui No.2 Provincial People’s Hospital, Anhui, People’s Republic of China Objective: We reported a case of pathologic type transformed from adenocarcinoma to small-cell lung cancer (SCLC) after being treated with third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). Materials and methods: The lung cancer pathologic type was transformed from adenocarcinoma to SCLC after the treatment of third-generation EGFR-TKI for 4.3 months. Four times of lung biopsies were conducted at a different time and different lesions. And the patient was treated with a variety of regimens after SCLC transformation, including etoposide combined with carboplatin (EC), irinotecan combined with oxaliplatin (IO), Abraxane, and Apatinib. These treatments got a good response, but quick progression.We alsomonitored the dynamic change of serum neuron-specific enolase (NSE) and pro-gastrin releasing peptide (Pro-GRP). Results: Adenocarcinoma could transform into SCLC after the treatment of TKI. Tumor cells were heterogeneity, so adenocarcinoma and SCLC could be co-existed. The fluctuation of the NSE was consistent with the response of treatment and the progression of the tumor. Conclusion: Regimens for the primary SCLC were also available for the transformed SCLC, but the duration of the response was short. NSE could be an effective biomarker for dynamic monitoring of the efficacy in SCLC transformation.
Títle Motivation and Learning Strategies in University Students : adaptation of the Motivated Strategies Learning Questionnaire to the Portuguese population

Promoting academic achievement in university studen ts calls for the use of specific tools for identify ing variables that interfere with students’ motivation a d learning strategies. In view of this need, the Motivated Strategies for Learning Questionnaire – MSLQ was ad apted to the Portuguese population, by analysing it s acceptability and levels of internal consistency of MSLQ sub-scales. A short version of 28 items was o btained after validating this tool, which allowed for a mor e time-cost efficient identification of the dimensi ons involved in motivation and learning strategies used by unive rsity students.
MAXIMIZING AIR QUALITY INSIDE ENCLOSED CABS WITH UNI-DIRECTIONAL FILTRATION AND PRESSURIZATION SYSTEM

Enclosed cabs have been used on surface mining equipment for many years to protect equipment operators from health and safety hazards. The surface mining and quarrying process is a highly mechanized process that generates large quantities of respirable dust. Due to economic factors, more older mining equipment is being used today than in years past. With this older equipment, it is common to observe deterioration of many components on the enclosed cabs which greatly reduce their protection effectiveness. NIOSH has performed a number of different field studies, as well as a comprehensive laboratory study evaluating various factors and parameters regarding enclosed cabs. NIOSH has recently completed a cooperative research effort with Sy-Klone International and Vulcan Materials Company to evaluate the effectiveness of a newly designed uni-directional filtration and pressurization system that brings all the clean filtered air in at the roof of the cab and extracts all recirculated air near the floor. This design provides the highest air quality to the equipment operator. Testing on this new system showed an almost 10-fold reduction in respirable dust inside the enclosed cab. The unidirectional design is easy to incorporate and should be considered for all new and retrofit systems in surface mining equipment.
Union of the Physically Impaired Against Segregation

These ‘comments’ were written by Vic Finkelstein for, and adopted by, members of UPIAS. It incorporates amendments suggested by Paul Hunt, Dick Leaman and Ken Davis. The ‘comments’ document is one of three included in the booklet Fundamental Principles of Disability (1975) published and distributed by UPIAS. The other documents are the ‘Summary of the Discussion’ (prepared by Dick Leaman) and The Disability Alliance’s ‘comments’ provided by them. The UPIAS statement read out by Paul Hunt at the beginning of the discussion between representatives of the two organisations was written by him for, and adopted by, members of, UPIAS: this includes the conditions for the meeting and the three Fundamental Principles that guided UPIAS practice and supplied the title of the complete booklet.
OTT_A_210739 8935..8945

Fang Xue Qi Rong Li Yan Hua Xu Hai Bin Zhou 1Department of Gynaecology and Obstetrics, Jinan Maternal and Child Health Hospital Jinan, Shandong 250012, People’s Republic of China; 2Infertility Center, Department of Gynaecology and Obstetrics, Qilu Hospital of Shandong University, Jinan, Shandong 250012, People’s Republic of China Background: The aberrant expression of microRNA-139-3p (miR-139-3p) has been recently involved in the development of multiple tumor types, but its function in ovarian cancer remains not well investigated. In this study, we mainly investigated the function of miR-139-3p in the progression of ovarian cancer. Methods: The levels of miR-139-3p in ovarian cancer cells and tissues were detected using quantitative real-time-PCR (qRT-PCR) assay. The proliferation, colony formation, migration and invasion of ovarian cancer cell were determined, respectively. A luciferase reporter assay was used to confirm ELAV Like RNA Binding Protein 1 (ELAVL1) was a target gene of miR-139-3p. The expression of ELAVL1 was detected using Western blotting and immunofluorescence staining assay. The roles of miR-139-3p on the growth and metastasis of ovarian cancer cell in vivo were explored using transplanted tumor model and experimental lung metastasis model. Results: MiR-139-3p was down-regulated in ovarian cancer tissues and ovarian cancer cell lines (SK-OV-3, A2780 and OVCAR-3). Overexpression of miR-139-3p decreased the growth, colony formation, migration and invasiveness of SK-OV-3 and OVCAR-3 cells. Moreover, overexpression of miR-139-3p reduced the growth and lung metastasis of ovarian cancer cells in vivo. The luciferase reporter gene assay indicated that ELAVL1 was a target of miR-139-3p and its expression was negatively regulated by miR-139-3p. Furthermore, the expression of ELAVL1 was inversely correlated with miR-139-3p level in ovarian cancer tissue. Conclusion: Taken together, we demonstrated that miR-139-3p regulated ovarian cancer growth and metastasis by modulating the expression of ELAVL1.