Miracle-dz/UniFAR-FTUs huggingface dataset:
Characteristics and Predictors of HCAPHS Non-Response after Spine Surgery.

STUDY DESIGN Retrospective cohort study OBJECTIVE. : To assess non-responder biases for the HCAHPS survey following spine surgery. SUMMARY OF BACKGROUND DATA The Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey is a publicly reported patient satisfaction survey. In addition to having the potential of impacting a hospital's reputation, it is directly linked to government reimbursement. However, it is known that a minority of patients return this survey, and it is expected that there are non-responder biases. METHODS All adult inpatient spine surgery patients at a single institution between January 2013-August 2017 at a single institution were selected for retrospective analysis. Patient demographics and perioperative outcomes were assessed as potential predictors of not returning HCAHPS surveys. Univariate and multivariate analyses were performed. RESULTS Of 5,517 spine surgeries analyzed, 1,505 (27.3%) patients returned the HCAHPS survey. Response rate was variable based on patient characteristics (with statistically significant differences based on age, functional status, race, and ASA score) but not variable based on anatomic region of the spine surgery. Multivariate analysis revealed that patients who did not return the HCAHPS survey were more likely to be black/African American (OR = 2.8, p < 0.001), have a higher ASA score (OR 1.76, p < 0.001), and have had a major adverse event (OR = 1.66; p = 0.001), minor adverse event (OR = 2.50; p < 0.001), discharged to a destination other than home (OR = 2.16, p < 0.001), hospital readmission (OR = 2.58; p < 0.001), and a long hospital length of stay (OR = 1.28, p = 0.001). CONCLUSION For spine surgery patients, patient characteristics and perioperative outcomes were found to be significantly associated with the non-responder bias for HCAHPS surveys. Although the potential resultant bias in HCAHPS scores cannot be directly determined, this must be considered in interpreting the results of such satisfaction surveys given that less than one third of patients actually completed this survey in the study population. LEVEL OF EVIDENCE 3.
A Qualitative Exploration of Return to Work in the First 3-Years After Serious Injury.

OBJECTIVE To explore how people with serious injuries returned to paid employment in the first 3-years after injury. METHODS Fifty-four adult survivors of serious injuries were interviewed at 3-years post-injury, all of whom had returned to work and were currently employed. A framework analysis approach was undertaken. RESULTS Participant decisions and actions taken to return to work (RTW) were influenced by their resilience, approach to adjusting goals, priorities and plans, and how social connections and relationships were used and maintained. The environment in which these decisions and actions were taken shaped opportunities for work in meaningful, appropriate and sustained employment. CONCLUSIONS Our study of 54 people who RTW indicated the importance of personal adjustments and resources, positive social relations, and advanced planning aligning with responsive employers, insurers and health professionals for successful RTW.
Trend of antidepressants before, during, and after pregnancy across two decades—A population‐based study

Factors that influence antidepressant (AD) prescription and use during pregnancy are multiple including, in particular, the balance between the potential risk of untreated depression and the potential risk of AD treatment. Surveillance of temporal trends of AD use might identify areas requiring further research. We studied the use of ADs before, during, and after pregnancy using national data across two decades in Denmark.
Developement of health risk rating scale for indoor airborne fungal exposure

Abstract This paper aims to quantify airborne fungal load in air-conditioned rooms and develop a health risk rating scale for different indoor environments. Five sampling locations in Kolkata frequented by a heterogeneous human population, containing various types of fungal growth-promoting substances (FGPS) like old documents, food items, waste hair, etc. were chosen as sampling locations where an Andersen Two-Stage Cascade Impactor was ran using Rose Bengal agar and Potato Dextrose agar media plates. Total spore load (CFU/m3), species diversity, species dominance, human exposure time, susceptible age and FGPS were considered the risk factors for this study. A risk rating scale was developed after evaluating the relative importance of these different factors in relation to human health. The most dominant genera were Aspergillus, followed by Penicillium. Maximum CFU was observed at library, followed by computer room.
The Mars1 kinase confers photoprotection through signaling in the chloroplast unfolded protein response

In response to proteotoxic stress, chloroplasts communicate with the nuclear gene expression system through a chloroplast unfolded protein response (cpUPR). We isolated Chlamydomonas reinhardtii mutants that disrupt cpUPR signaling and identified a gene encoding a previously uncharacterized cytoplasmic protein kinase, termed Mars1—for mutant affected in chloroplast-to-nucleus retrograde signaling—as the first known component in cpUPR signal transmission. Lack of cpUPR induction in MARS1 mutant cells impaired their ability to cope with chloroplast stress, including exposure to excessive light. Conversely, transgenic activation of cpUPR signaling conferred an advantage to cells undergoing photooxidative stress. Our results indicate that the cpUPR mitigates chloroplast photodamage and that manipulation of this pathway is a potential avenue for engineering photosynthetic organisms with increased tolerance to chloroplast stress.
Nasal loop myopexy as a primary procedure to correct exotropia hypotropia complex in high myopia

ABSTRACT Purpose: To evaluate success of nasal loop myopexy as a primary procedure in correcting the ocular deviation in primary position when combined with recession and resection procedure (R&R) in exotropia hypotropia complex in high myopia and to explore the probable cause for deviation. Case reports: We present a case series of three adult males with exotropia hypotropia complex and high myopia with large angle exotropia and hypotropia, with deflection of the courses of superior and medial recti seen intraoperatively. We performed a conventional recession and resection procedure, which was combined with a nasal loop myopexy between the superior rectus (SR) and medial rectus (MR) in the same session, under local anesthesia, to correct the deflected course of SR and MR; with the aim of correcting the deviation in primary position and improving ocular motility, mainly elevation in abduction. Results: We present a case series of three adult males with exotropia hypotropia complex, who were operated between March 2017 and October 2017. In all the three cases described above, it was noted that the preoperative exotropia and hypotropia improved following the combination of nasal loop myopexy with a conventional recession and resection procedure, as shown by improvement in ocular deviation in the primary position (measured by prism bar cover test, PBCT). First patient improved from 50 prism exotropia with 16 prism hypotropia to 5 prisms exophoria and 6 prisms hypotropia in left eye. Second patient improved from 45 prism right exotropia and 10 prism hypotropia to 10 prisms exotropia and 6 prism hypotropia. Third patient improved from 40 prism left exotropia and 20 prisms hypotropia to 10 prism esotropia and 5 prisms hypotropia. Ocular motility showed no restriction following surgery in any of the gazes. Limitation of elevation in abduction, caused due to SR deflection, improved due to repositioning of SR and MR in their anatomical positions in all the cases. In the first patient elevation in abduction improved from −4 to −1; in the second and third patients, it improved from −2 to 0. None of the three adult patients experienced any side effects following the procedure. Conclusion: The combination of recession and resection procedures with nasal loop myopexy was found to be effective in correcting the ocular deviation and limitation to elevation in abduction by correcting the deflected course of superior rectus and medial rectus to result in an effective improvement of elevation in abduction. One case had an overcorrection of exotropia. There were no other major complications.
Fuzzy PI Gains Tuning By PSO And Genetic Algorithms Controls A Hybrid Indirect Matrix Converter

In this paper, we study the performance of a power active filtering of the current perturbation using a hybrid indirect matrix with a three cell flying capacitance; this hybrid structure is controlled by a fuzzy PI controller in which it gains are tuned with the PSO algorithm and genetic algorithm (GA). In the first part, we present the full grid model with the perturbation source, as well as a detail of the hybrid structure. In the second part, we explain the current perturbation identification technique, and then we passed to gains tuning used algorithms. The simulation results by MATLAB, Simscap/sim power system code shows a good performance of the fuzzy PI gains tuning by obtaining a low THD value in the filtration process.
Dysregulation of Intestinal Microbiota Elicited by Food Allergy Induces IgA-Mediated Oral Dysbiosis

Food allergy is a life-threatening response to specific foods, and microbiota imbalance (dysbiosis) in gut is considered a cause of this disease. Meanwhile, the host immune response also plays an important role in the disease. Notably, interleukin 33 (IL-33) released from damaged or necrotic intestinal epithelial cells facilitates IL-2-producing CD4 helper T (Th2) responses. However, causal relationships between the gut and oral dysbiosis and food allergy remain unknown. ABSTRACT Food allergy is a life-threatening response to specific foods, and microbiota imbalance (dysbiosis) in gut is considered a cause of this disease. Meanwhile, the host immune response also plays an important role in the disease. Notably, interleukin 33 (IL-33) released from damaged or necrotic intestinal epithelial cells facilitates IL-2-producing CD4 helper T (Th2) responses. However, causal relationships between the gut and oral dysbiosis and food allergy remain unknown. In this study, we analyzed effects of gut and oral dysbiosis on development of food allergy. A murine model of food allergy was established via ovalbumin (OVA) injection in BALB/c mice. Viable fecal bacteria were identified using matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS). il33 expression in colon-26 mouse colon cells stimulated by isolated fecal bacteria was quantified by real-time PCR. Intestinal T cells from the mice were analyzed by flow cytometry. Salivary IgA levels were quantified by enzyme-linked immunosorbent assay (ELISA), and IgA-bound oral bacteria were detected by flow cytometry. Among fecal bacteria, the abundance of Citrobacter sp. increased in the feces of allergic mice and induced il33 expression in colon-26 cells. Orally administered Citrobacter koseri JCM1658 exacerbated systemic allergic symptoms and reduced intestinal Th17 cells. Salivary IgA and IgA-bound oral bacteria increased in the allergic mice. Based on the results described above, food allergy induced both gut and oral dysbiosis. Citrobacter sp. aggravated allergy symptoms by inducing IL-33 release from intestinal epithelial cells.
Understanding interaction effect of arbuscular mycorrhizal fungi in rice under elevated carbon dioxide conditions

Arbuscular mycorrhizal fungi (AMF), particularly the Glomerales group, play a paramount role in plant nutrient uptake, and abiotic and biotic stress management in rice, but recent evidence revealed that elevated CO2 concentration considerably reduces the Glomerales group in soil. In view of this, the present study was initiated to understand the interaction effect of native Glomerales species application in rice plants (cv. Naveen) under elevated CO2 concentrations (400 ± 10, 550 ± 20, and 700 ± 20 ppm) in open‐top chambers. Three different modes of application of the AMF inoculum were evaluated, of which, combined application of AMF at the seedling production and transplanting stages showed increased AMF colonization, which significantly improved grain yield by 25.08% and also increased uptake of phosphorus by 18.2% and nitrogen by 49.5%, as observed at 700‐ppm CO2 concentration. Organic acids secretion in rice root increased in AMF‐inoculated plants exposed to 700‐ppm CO2 concentration. To understand the overall effect of CO2 elevation on AMF interaction with the rice plant, principal component and partial least square regression analysis were performed, which found both positive and negative responses under elevated CO2 concentration.
Optimization of a microarray for fission yeast

Bar-code (tag) microarrays of yeast gene-deletion collections facilitate the systematic identification of genes required for growth in any condition of interest. Anti-sense strands of amplified bar-codes hybridize with ~10,000 (5,000 each for up- and down-tags) different kinds of sense-strand probes on an array. In this study, we optimized the hybridization processes of an array for fission yeast. Compared to the first version of the array (11 µm, 100K) consisting of three sectors with probe pairs (perfect match and mismatch), the second version (11 µm, 48K) could represent ~10,000 up-/down-tags in quadruplicate along with 1,508 negative controls in quadruplicate and a single set of 1,000 unique negative controls at random dispersed positions without mismatch pairs. For PCR, the optimal annealing temperature (maximizing yield and minimizing extra bands) was 58℃ for both tags. Intriguingly, up-tags required 3× higher amounts of blocking oligonucleotides than down-tags. A 1:1 mix ratio between up- and down-tags was satisfactory. A lower temperature (25℃) was optimal for cultivation instead of a normal temperature (30℃) because of extra temperature-sensitive mutants in a subset of the deletion library. Activation of frozen pooled cells for >1 day showed better resolution of intensity than no activation. A tag intensity analysis showed that tag(s) of 4,316 of the 4,526 strains tested were represented at least once; 3,706 strains were represented by both tags, 4,072 strains by up-tags only, and 3,950 strains by down-tags only. The results indicate that this microarray will be a powerful analytical platform for elucidating currently unknown gene functions.
Evaluation of Polymorphisms rs762624 and rs3176336 of CDKN1A Gene and Risk of Colorectal Cancer

Aims: Progressive loss of cell cycle control is an important feature on the colorectal cancer. CDKN1A gene encoded p21 protein that’s one of the cyclin-dependent kinase inhibitors, plays a key role in regulating the cell cycle. The aim of this study was to Original Research Article British Journal of Medicine & Medical Research, 4(32): 5098-5106, 2014 5099 investigate associations of the CDKN1A gene polymorphism rs762624 and rs3176336 with risk of colorectal cancer in an Iranian population. Methods: A case-controls study was conducted to investigate the association of polymorphism rs3176336 and rs762624, with colorectal cancer risk in Iranian population. In this study 150 cases of sporadic CRC and 150 healthy controls were recruited, genomic DNA were extracted from peripheral blood, the genotypes were determined using the polymerase chain reaction and restriction fragment length polymorphism (PCRRFLP) method and the result was validated by direct sequencing. Results: The rs762624 frequencies of the AA, AC, and CC genotypes among cases were 9.3%, 74.7%, and 16%, respectively, while in controls genotype frequencies were 10%, 74%, and 16%, respectively. The rs3176336 frequencies of the AA, AC, and CC genotypes among cases were 29.3%, 18% and 52.7%, respectively, while in controls genotype frequencies were18%, 20%, and 62%, respectively. No association was found for the CDKN1A rs3176336 AT/AA genotype (Adjusted odds ratio (OR), 0.726, 95% confidence interval (CI), 0.365–1.443 for AT genotype; OR, 1.67, 95% CI, 0.754–3.702 for AA genotype) with risk of colorectal cancer, compared with the TT genotype. In our research, we could not found significant relation between stage of colorectal cancer and genotypes of rs762624 and rs3176336 polymorphisms (p=0.081, p=0.988). Conclusion: Present data do not confirm association of rs3176336 and rs762624 polymorphisms with susceptibility of Iranian to colorectal cancer.
Psychiatric rehabilitation degree- gran ting programs and practitioners' knowledge and practice patterns

Abstract This article reports on a study that investigated the relationship between practitioners' level of knowledge of psychiatric rehabilitation and certain professional characteristics of 279 practitioners from New Jersey and Pennsylvania. Having received a degree from a university psychiatric rehabilitation specialty department had a significant and substantial relationship with the study's knowledge variables, and was superior to other factors in predicting knowledge level of psychiatric rehabilitation goals, beliefs, and practices. However, relatively few (16%) of these practitioners had benefitted from this type of training so that the majority of these practitioners did not possess the basic knowledge of modern principles and practices. It was concluded that a serious information and technology transfer gap exists between the psychiatric rehabilitation knowledge base and practices in the field. Recommendations were suggested based upon the study's findings.
Is it possible to establish reference values for ankle muscle isokinetic strength? A meta-analytical study

BACKGROUND: The importance of measuring ankle muscle strength (AMS) has been demonstrated in a variety of clinical areas. Much data has been accumulated using the Cybex Norm isokinetic dynamometer but a uniform framework does not exist. OBJECTIVE: To identify pertinent studies which have used the Cybex Norm to measure AMS in order to establish reference values. METHODS: A narrative review of the literature was used to identify papers that have used the Cybex Norm to measure isokinetic concentric and eccentric AMS. RESULTS: Fifty five research papers were identified but each study used a different isokinetic protocol. CONCLUSIONS: It is not possible to produce AMS reference values due to the wide variation in data collection methods. This is therefore an area of research that needs further exploration.
Induction of Labour with Prostaglandin E2 Tablets

Prostaglandin E2 tablets were administered orally following amniotomy to 46 primagravid and 54 multiparous women at or near term. Of these, 96 women had vaginal delivery with an average induction-delivery interval of 8 1/2 hours. Vomiting and or diarrhoea occurred in 9 women. No adverse effects on the foetus were apparent. The safety, ease and convenience of administration were obvious to the patients and staff.
Stator and Rotor Temperatures Estimation in Three-Phase Open-ended Winding Induction Motor Drives

The main aim of this paper is to present a stator and rotor temperatures monitoring technique for open-ended winding induction motor drives. The thermal status of the electrical machine is periodically monitored by imposing the current flowing in one of its phases to zero and estimating the magnetizing voltage and the air gap active power absorbed by the motor. From the last quantities a satisfying estimation of both stator and rotor resistances at steady state can be carried out with limited computational efforts, without additional sensing. Then, stator and rotor temperatures are calculated from the change of these resistances. Simulations and experimental tests on a 2.2kW induction motor drive confirm the feasibility and effectiveness of the method.
The use of fine needle aspiration biopsy in the diagnosis of thyroid nodules

Introduction. Fine needle aspiration (FNA) is a simple, inexpensive, easily performed outpatient procedure which can provide a rapid diagnosis. It is eminently suitable for the investigation of superficial palpable lesions in many sites, including the thyroid gland. Cytological examination of aspirated material can detect thyroiditis, toxic hyperplasia and colloid goiters as well as neoplastic processes, epithelial, lymphoid and metastatic changes. Aim. The aim of this study was the analysis of the results of FNAB in thyroid nodules in children, the usefulness of FNAB in the therapeutic procedures and comparison of the cytologic changes with the postoperative changes of the thyroid. Material and methods. Thirty seven patients (33 females and 4 males) of the Clinical Department of Endocrinology and Pediatrics in the Warsaw University of Medicine, were qualified to FNA because of the presence of thyroid nodules. The age of patients varied from 7 to 18 years old. The microscopical changes were described according the cytological picture and graded by recommended diagnostic categories using Bethesda System. Results. In most patients (31/37) the results of FNA were consistent with the grade 2 according to Bethesda System, in one patient with the grade 1, in two patients with the grade 3, in another two patients with the grade 5, and finally in one patient with the grade 6 corresponding to papillary carcinoma. The patients presented in the article did not follow the core needle biopsy, but we have demonstrated that in our group of patients FNA was a sensitive test. The results of FNA coincided with the histopathological results of surgical specimens. Conclusions. We have demonstrated that the main purpose of this technique is to provide a differential diagnosis between benign and malignant changes enabling appropriate therapeutic management and the determination of the correct surgical procedure when surgery is required.
Tisser le Web Social des Objets : Permettre une Interaction Autonome et Flexible dans l’Internet des Objets

L’Internet des Objets (IoT) vise a creer un eco-systeme global et ubiquitaire compose d’un grand nombre d’objets heterogenes. Afin d’atteindre cette vision, le World Wide Web apparait comme un candidat adapte pour interconnecter objets et services a la couche applicative en un Web des Objets (WoT). Cependant l’evolution actuelle du WoT produit des silos d’objets et empeche ainsi la mise en place de cette vision. De plus, meme si le Web facilite la composition d’objets et services heterogenes, les approches existantes produisent des compositions statiques incapables de s’adapter a des environnements dynamiques et des exigences evolutives. Un autre defi est a relever: permettre aux personnes d’interagir avec le vaste, evolutif et heterogene IoT.Afin de repondre a ces limitations, nous proposons une architecture pour IoT ouvert et autogouverne, constitue de personnes et d’objets situes, en interaction avec un environnement global via des plateformes heterogenes. Notre approche consiste de rendre les objets autonomes et d’appliquer la metaphore des reseaux sociaux afin de creer des reseaux flexibles de personnes et d’objets. Nous fondons notre approche sur les resultats issus des domaines des multi-agents et du WoT afin de produit un WoT Social.Notre proposition prend en compte les besoins d’heterogeneite, de decouverte et d’interaction flexible dans l’IoT. Elle offre egalement un cout minimal pour les developpeurs et les utilisateurs via differentes couches d’abstraction permettant de limite la complexite de cet eco-systeme. Nous demontrons ces caracteristiques par la mise en oeuvre de plus scenarios applicatifs.