Miracle-dz/UniFAR-FTUs huggingface dataset:
The Transcultural Self-Efficacy Tool (TSET), a Journal Article, Holistic Evaluation of Evidence, and Statistical Thoughtfulness

As author of the Transcultural Self-Efficacy Tool (TSET), I am happy when others wish to apply, adapt, and build upon my work (as well as offer alternate perspectives, suggestions, or questions). Careful review of literature and resources is a first step toward achieving quality outcomes (Spurlock, 2019a). Quality is essential for moving the nursing discipline forward; expanding depth and breadth of theory, research, and practice; and engaging in global and interdisciplinary scholarship. When reading a recent article about a translated version of the TSET authored by Tian and colleagues (Tian et al., 2021), I noticed some discrepancies, misinformation, and areas for enhancement. My motivation in writing this commentary is to (a) prevent perpetuation of repeated errors and misinformation, (b) succinctly share additional information for clarity and contemplation, and (c) advocate a holistic approach to evaluating research evidence where “practical importance,” “conceptual congruence,” and “content knowledge and judgment” as well as statistical outcomes are thoughtfully considered in all phases of the research and publication process. Five discussion areas will be presented followed by concluding recommendations.
Influence of Family and Community Socioeconomic Status on the Risk of Adolescent Drug Use

Abstract Background: Adolescent drug use increases the risk of mental, physical and social problems later in life and so it is important to understand its complex etiology that likely includes socioeconomic status (SES). We undertook the present analysis using data from a population-based retrospective cohort study to examine the influence of family and community SES in relation to adolescent drug use. We hypothesized that lower levels of community and parental SES would increase the risk of use and that there would be stronger associations for the more proximate family-level factors. Methods: We used self-administered questionnaires (N=1,402) to obtain information on use of marijuana, inhalants, heroin, cocaine/crack, psychedelics/hallucinogens, Ritalin without a prescription, and club drugs during adolescence. Family SES was gathered from birth certificate data on maternal educational level and paternal occupation. Community SES characteristics at birth, age 10 and age 18 were obtained from the US Census Bureau. Results: An increased risk of adolescent drug use was associated with lower maternal education, non-white collar occupations among fathers, and lower community median income, and poverty and unemployment levels at age 18. The strongest associations were seen for the use of multiple drugs (Risk Ratio (RR): 1.7, 95% CI: 1.4-2.2), inhalants (RR: 2.5, 95% CI: 1.5-2.2), crack/cocaine (RR: 2.8, 95% CI: 1.7-4.5), psychedelics/hallucinogens (RR: 1.8, 95% CI: 1.4-2.4), and club/designer drugs (RR: 1.8, 95% CI: 1.2-2.7) among adolescents whose mothers had only a high school education. Conclusions: These results suggest that use of certain drugs during adolescence is associated with both family and community SES measures. However, maternal education appears to have the greatest influence on use, suggesting that a multi-level approach that engages mothers is needed to prevent adolescent drug use.
GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo

Following fertilization, the genomes of the germ cells are reprogrammed to form the totipotent embryo. Pioneer transcription factors are essential for remodeling the chromatin and driving the initial wave of zygotic gene expression. In Drosophila melanogaster, the pioneer factor Zelda is essential for development through this dramatic period of reprogramming, known as the maternal-to-zygotic transition (MZT). However, it was unknown whether additional pioneer factors were required for this transition. We identified an additional maternally encoded factor required for development through the MZT, GAGA Factor (GAF). GAF is necessary to activate widespread zygotic transcription and to remodel the chromatin accessibility landscape. We demonstrated that Zelda preferentially controls expression of the earliest transcribed genes, while genes expressed during widespread activation are predominantly dependent on GAF. Thus, progression through the MZT requires coordination of multiple pioneer-like factors, and we propose that as development proceeds control is gradually transferred from Zelda to GAF.
Reading the mind in cartoon eyes: Comparing human versus cartoon emotion recognition in those with high and low levels of autistic traits

People who have a high degree of autistic traits often underperform on theory of mind tasks such as perspective-taking or facial emotion recognition compared to those with lower levels of autistic traits. However, some research suggests that this may not be the case if the agent they are evaluating is anthropomorphic (i.e. animal or cartoon) rather than typically human. The present studies examined the relation between facial emotion recognition and autistic trait profiles in over 750 adults using either a standard or cartoon version of the Reading the Mind in the Eyes (RME) test. Results showed that those scoring above the clinical cut off for autistic traits on the Autism Quotient performed significantly worse than those with the lowest levels of autistic traits on the standard RME, while scores across these groups did not differ substantially on the cartoon version of the task. These findings add further evidence that theory of mind ability such as facial emotion recognition is not at a global deficit in those with a high degree of autistic traits. Instead, differences in this ability may be specific to evaluating human agents.
The Persistence of Vaccine Hesitancy: COVID-19 Vaccination Intention in New Zealand

Building public trust and willingness to vaccinate against COVID-19 is as important as developing an effective vaccine. However, a significant minority of the public are unwilling or hesitant to take a COVID-19 vaccine, when available. A nationally representative sample survey (N = 1040) was conducted in July 2020 in New Zealand to identify factors associated with COVID-19 vaccine intention. A 14-item general vaccine hesitancy scale was tested and found to be significantly associated with COVID-19 vaccine intention. A communication campaign from trusted scientific experts, with information that addresses prevailing concerns about vaccines, is likely to help increase COVID-19 vaccine uptake.
Improvement in nitrogen availability, nitrogen uptake and growth of aerobic rice following soil acidification

Abstract A yield decline and increase in soil pH under continuous cropping of aerobic rice have been reported in previous studies. However, the underlying mechanisms governing the poor growth and low yield of aerobic rice following an increase in soil pH are unknown. The objective of the present study was to determine the effect of soil acidification on the soil nutrient availability, plant nutrition and growth of aerobic rice grown in continuously cropped aerobic soil. Two pot experiments were conducted using soil from a field where aerobic rice had been grown for 13 consecutive seasons. Soil was acidified by adding 50–300 mL of 0.05 mol L–1 sulfuric acid to 3.0 kg of air-dried soil to achieve a range of soil pH levels. Rice was grown aerobically with N rates of 0–1.2 g per pot using urea or ammonium sulfate. Soil chemical properties were measured as were leaf nutrient concentrations, plant growth parameters, and the above-ground N uptake. A 5.5-fold and 1.5-fold increase in soil ammonium and nitrate were observed, respectively, after adding sulfuric acid. Plant growth and N uptake improved significantly with soil acidification, regardless of N rates or N sources, and were associated with an improvement in plant N nutrition. The application of N had greater positive effects on plant growth and N uptake than soil acidification. The growth response to soil acidification reduced as the rate of N application increased. These results suggest that the yield decline of continuous aerobic rice is probably associated with a reduction in soil N availability and plant N uptake as a result of a gradual increase in soil pH.
Pulmonary nodule radiological diagnostic algorithm in lung cancer screening

Publications of the final results of the two largest randomized lung cancer screening (LCS) trials in the United States and Europe confirmed the reduction in the mortality rate associated with the use of screening with low-dose computed tomography (LDCT). Results of these trials led to widespread acceptance of LCS in properly defined high-risk populations, and its implementation in the clinical practice. Many countries started preparation for national LCS and refreshed still open debate about lung nodule management. Detection of lung cancer in the early stage with a reduction of lung cancer mortality requires dedicated programs with optimized protocols, including a specified pulmonary nodule diagnostic algorithm. The screening protocol should be clear with a precise nodule diameter or volume threshold, based on which a positive screen result is defined. The application of risk-prediction models and the introduction of the semiautomated assessment of detected nodules improves screening accuracy and should be applied in LCS protocols as verified tools to aid radiological diagnosis. In this review, we have summarized recent data about the radiological protocols from the most important LCS programs and pulmonary diagnostic algorithms. These protocols should be taken into consideration in the ongoing and planned LCS programs.
Factors Associated With Clinical Improvement and the Disappearance of Calcifications After Ultrasound-Guided Percutaneous Lavage of Rotator Cuff Calcific Tendinopathy: A Post Hoc Analysis of a Randomized Controlled Trial

Background: Calcific tendinitis of the rotator cuff is a frequent cause of shoulder pain. Ultrasound-guided percutaneous lavage (UGPL) is an effective treatment, but factors associated with good clinical and radiological outcomes still need to be identified. Purpose: To study the clinical, procedural, and radiological characteristics associated with improved shoulder function and the disappearance of calcification on radiograph after UGPL. Study Design: Case-control study; Level of evidence, 3. Methods: This is a post hoc analysis of the CALCECHO trial, a double-blinded randomized controlled trial conducted on 132 patients. The trial assessed the effect of corticosteroid injections after UGPL, and patients were randomly assigned to receive either corticosteroid or saline solution in the subacromial bursa. We analyzed all patients included in the randomized controlled trial as 1 cohort. We collected the patients’ clinical, procedural, and radiological characteristics at baseline and during follow-up (3, 6, and 12 months). Univariable analysis, followed by multivariable stepwise regression through forward elimination, was performed to identify the factors associated with clinical success (Disabilities of the Arm, Shoulder and Hand [DASH] score <15) or the disappearance of calcification. Results: Good clinical outcomes at 3 months were associated with steroid injections after the procedure (odd ratio [OR], 3.143; 95% CI, 1.105-8.94). At 6 months, good clinical evolution was associated with a lower DASH score at 3 months (OR, 0.92; 95% CI, 0.890-0.956) and calcium extraction (OR, 10.7; 95% CI, 1.791-63.927). A lower DASH at 6 months was also associated with a long-term favorable outcome at 12 months (OR, 0.939; 95% CI, 0.912-0.966). Disappearance of calcification at 3 and 12 months occurred more frequently in patients in whom communication was created between the calcification and the subacromial bursa during the procedure (OR, 2.728 [95% CI, 1.194-6.234] at 3 months; OR, 9.835 [95% CI, 1.977-48.931] at 12 months). Importantly, an association between calcification resorption and good clinical outcome was found at each time point. Conclusion: Assessing patients at 3 months seems to be an essential part of their management strategy. Calcium extraction and creating a communication between the calcific deposits and subacromial bursa are procedural characteristics associated with good clinical and radiological evolution.
Black tea bioactives as inhibitors of multiple targets of SARS-CoV-2 (3CLpro, PLpro and RdRp): a virtual screening and molecular dynamic simulation study

Abstract The global pandemic due to the novel Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) has taken more than a million lives. Lack of definitive vaccine/drugs against this highly contagious virus has accelerated exploratory research on novel natural and synthetic inhibitors. Tea is a rich source of bioactives and known to have antiviral properties. In this study, an in silico strategy involving ADMET property screening, receptor–ligand docking and molecular dynamic (MD) simulation was employed to screen potential tea bio-active inhibitors against three selected targets (RdRp, 3CLpro and PLpro) of SARS-CoV-2. Among the 70 tea bioactives screened, theaflavin 3,3’-di-gallate (TF3), Procyanidin B2 and Theaflavin 3-gallate (TF2a) exhibited highest binding affinities towards RdRp, 3CLpro/Mpro and PLpro targets of SARS-CoV-2 with low docking scores of −14.92, −11.68 and −10.90 kcal/mol, respectively. All of them showed a substantial number of hydrogen bonds along with other interactions in and around the active sites. Interestingly, the top bioactives in our study showed higher binding affinities compared with known antiviral drugs. Further, the top protein–ligand complexes showed less conformational changes during binding when subjected to MD simulation for 100 nanoseconds. The MMPBSA results revealed that RdRp-TF3, 3CLpro-Procyanidin B2 and PLpro-TF2a complexes were stable with binding free energies of −93.59 ± 43.97, −139.78 ± 16.51 and −96.88 ± 25.39 kJ/mol, respectively. Our results suggest that theaflavin 3,3’-digallate, Theaflavin 3-gallate and Procyanidin B2 found in black tea have the potential to act as inhibitors for selected targets of SARS-CoV-2 and can be considered as drug candidates in future studies against COVID-19. Graphical Abstract Communicated by Ramaswamy H. Sarma
A study of pregnancy rates in “cleared” male factor couples

Background Among couples with male factor infertility, the natural pregnancy rates associated with classic male factor treatments are well described. In couples with unexplained infertility, the proportion due to occult male factor is unclear. We hypothesized that many men diagnosed with unexplained infertility are actually fertile. We describe the 1-year natural pregnancy rates among couples in whom the male partner has been “cleared” of infertility on urologic evaluation. Methods Consecutive infertile couples were recruited from a single practice (PJT) over a 3-year period. A thorough male factor evaluation was performed, including a history, physical examination and 2 semen analyses. Based on this assessment, male partners in whom bulk semen parameters were normal were “cleared” from further evaluation. Lifestyle modifications were allowed, but no medical or surgical treatments were offered. The presence or absence of a female factor evaluation was not required for study inclusion. Subjects were followed for 12 months or until a pregnancy was achieved. Subjects were contacted via telesurvery 1-year later and pregnancy status ascertained. Simple descriptive statistics were used to evaluate the significance of observations. Results Fifty-four men were enrolled in the study. The mean duration of infertility was 1.5 years (range, 0.4 to 4.0 years) and the mean male and female partner ages were 38.6 and 35.1 years, respectively. On evaluation, 40% of men were noted to have significant fertility risks that included a clinical varicocele, exposures, and androgen altering medications. Among n=31 couples with known pregnancy outcomes, 20/31 (65%) conceived naturally at a mean of 9 months after evaluation (range, 3–30 mos). Another 1/31 (3%) couples conceived with intrauterine insemination (IUI) and 4/31 (13%) conceived with IVF-ICSI. Conclusions A significant proportion of men diagnosed with unexplained infertility have lifestyle risk factors on urologic evaluation. Care in the form of counseling at-risk patients regarding lifestyle issues, in the absence of formal treatment, may have value in improving the fertility potential in this population. Indeed, natural conception rates among men identified with unexplained infertility are substantial and suggest that many of these men are truly fertile.
Steam extraction of essential oils: Investigation of process parameters

The steam extraction was used to investigate the process parameters important in the extraction of essential oils from the leaves of the Eucalyptus tree. The diffusion process and the application of Fick's law, as well as the temperature dependence of the diffusion coefficient were exhibited. This has enabled the setting up of a model that takes account of the initial amount of oil in the leaves and the effect of temperature. From the literature, it can be seen that the oil collected after an extended time represents all the oil that is present in the material initially. The research conducted indicates that the extraction temperature has a significant effect on the percentage of the initial oil that is eventually extracted, with the amount of oil extracted apparently decreasing for lower temperature. This effect could, however, be modelled accurately by simply considering the temperature dependence of the diffusion coefficient. This model can lead to the design of an optimum steam extraction plant. L'extraction par vapeur a ete utilisee pour etudier les parametres importants du processus de l'extraction des huiles essentielles des feuilles de l'eucalyptus. Le processus de diffusion et l'application de la loi de Fick, ainsi que la dependance par rapport a la temperature du coefficient de diffusion ont ete montres. Ceci a permis la mise en place d'un modele qui prend en compte la quantite initiale d'huile dans les feuilles et l'effet de la temperature. Le coefficient de diffusion etabli dans cette etude de recherche tombe dans l'intervalle des valeurs rapportees par la litterature pour les huiles essentielles. A partir de la litterature, on peut voir que l'huile collectee apres une periode prolongee represente la totalite de l'huile presente initialement dans le materiau. L'etude presente indique que la temperature d'extraction a un effet significatif sur le pourcentage de la quantite initiale d'huile eventuellement extraite, la quantite extraite diminuant apparemment pour les temperatures plus basses. Cet effet pourrait cependant etre modelise exactement en considerant simplement la dependance par rapport a la temperature du coefficient de diffusion. Ce modele peut conduire a la conception d'une usine d'extraction optimale a la vapeur.
The impact of rice bran oil consumption on the serum lipid profile in adults: a systematic review and meta-analysis of randomized controlled trials

Abstract Dyslipidemia/hyperlipidemia is recognized among the risk factors for lifestyle related diseases. A healthy diet, rich in vegetable oils such as rice bran oil (RBO), may aid to improve serum lipid levels. Thus, the aim of this study was to assess the effects of rice bran oil (RBO) consumption on serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c) and triglyceride (TG) levels in adults. The following online databases were searched for manuscripts published until October 7th 2020: PubMed/Medline, Scopus, Clarivate Analytics’ Web of Science, Cochrane Central Register of Controlled Trials, and Google Scholar. The effect sizes were expressed as weighted mean difference (WMD) with 95% confidence intervals (CI). A total of 8 eligible trials with 14 effect sizes were included in this meta-analysis. Our analysis revealed that the consumption of RBO significantly decreased serum TC (WMD: −7.29 mg/dL, 95% CI: −11.32, −3.25, P = 0.000), LDL-c (WMD: −7.62 mg/dL, 95% CI: −11.10, −4.14, P = 0.000) and TG (WMD: −9.19 mg/dL, 95% CI: −17.99, −0.38, P = 0.041) levels. So, available evidence suggests that RBO consumption can significantly decrease serum TC, LDL-c and TG levels. Hence, it may play a role in reducing dyslipidemia/hyperlipidemia risk.
A novel microduplication in INPP5A segregates with schizophrenia spectrum disorder in the family of a patient with both childhood onset schizophrenia and autism spectrum disorder

Childhood‐Onset Schizophrenia (COS) is a very rare and severe psychiatric disorder defined by adult schizophrenia symptoms occurring before the age of 13. We report a microduplication in the 10q26.3 region including part of the Inositol Polyphosphate‐5‐Phosphatase A (INPP5A) gene that segregates with Schizophrenia Spectrum Disorders (SSDs) in the family of a female patient affected by both COS and Autism Spectrum Disorder (ASD). Phenotyping and genotyping (including CGH‐array) were performed for mother, healthy sister, and affected child according to the GenAuDiss protocol (NCT02565524). The duplication size is 324 kb and is present in a patient with COS and in her mother with SSD, but not in the patient's healthy sister. INPP5A encodes a membrane‐associated 43 kDa type I inositol 1,4,5‐trisphosphate (InsP3) 5‐phosphatase. This protein is found both in mouse and human brains and we found that its Drosophila homologue 5PtaseI is specifically expressed in the central nervous system. Hydrolyzed products from InsP3 5‐phosphatases mobilize intracellular calcium, which is relevant for dendritic spine morphogenesis in neurons and altered in both schizophrenia and ASD. These may constitute arguments in favor of this gene alteration in the pathophysiology of COS.
The melting of MgO studied by molecular dynamics simulation

Shell-model and rigid-ion molecular dynamics simulation based on the Lewis-Catlow and Sangster-Stoneham potential models has been used to study the melting of MgO. The simulations are performed on slabs of material with free surfaces in order to avoid superheating effects. The two potential models yield substantially different predictions for the melting temperature, with the Lewis-Catlow model being in rather close agreement with the experimental value. The inclusion of electronic polarizability of the ions has almost no effect on the melting temperature.