Miracle-dz/UniFAR-FTUs huggingface dataset:
A dual-band LC VCO using a switched current source for IMT-Advanced and UWB applications

This paper presents a dual-band CMOS LC voltage controlled oscillator (VCO) with a switched current source for 3.4–3.6 GHz IMT-Advanced and 4.2–4.8 GHz UWB applications. To accomplish dual-band operation, reconfigurable LC tank is adopted, and a switched current source has been used to guarantee robust start-up condition. Bias filters are used in VCO to suppress reference current noise and dynamic transient effects on the bias line. The simulated phase noises at 1 MHz offset frequency are −124 dBc/Hz at 3.6 GHz and −121 dBc/Hz at 4.8 GHz, respectively. Designed in TSMC 0.13 µm process, the VCO current dissipation is 2.8 mA at UWB band and 3.9 mA at IMT-Advanced band from 1.2 V power supply.
SAFCast: Smart Inter-Datacenter Multicast Transfer with Deadline Guarantee by Store-And-Forwarding

With the increasing demand of network services, many researches employ a Software Defined Networking architecture to manage large-scale inter-datacenter networks. Some of existing services such as backup, data migration and update need to replicate data to multiple datacenters by multicast before deadline. Recent works set up minimum-weight Steiner tree as routing paths for multicasting transfers to reduce bandwidth waste; meanwhile, using deadline-aware scheduling guarantees deadlines of requests. However, there is an issue of bandwidth competition among those works. SAFCast as a new algorithm is proposed for multicasting transfers and deadline-aware scheduling. In SAFCast, we develop a tree pruning process and make datacenters employ the store-and-forwarding mechanism to improve the issue of bandwidth competition. Meanwhile, more requests can be accepted by SAFCast. Our experimental result shows that SAFCast outperforms DDCCast in the acceptance rate by 16.5%. In addition, given a volume-to-price function for revenue, SAFCast can achieve 10% more profit than DDCCast. As a result, SAFCast is a better choice for cloud providers with the effective deadline guarantee and more efficient multicasting transfers.
A Flyback Converter Based Asymmetrical Cascaded H-Bridge 27 Level Grid Connected Inverter From A Single Source Using FPGA

Multilevel inverters(MLI) has many remarkable features when compared to the traditional two level inverters such as high dc link voltages, reduced harmonic distortion, less voltage stress and low electromagnetic interference. In spite of these advantages it have some major disadvantages when used for high level applications such as higher number of power switches, voltage balancing issues in H-bridge cells, higher number of dc sources and complex pulse width modulation (PWM) techniques. In order to eliminate these issues a number of MLI topologies have been proposed in recent papers. The project deals with a 27 level multilevel inverter utilizing reduced switches and a single source which is connected to the grid. A multi winding flyback transformer is used to provide power to the individual H-bridge cells. PODSPWM technique was employed to provide switching pulses. This solution reduces the cost, size, switch count and improve the efficiency. The simulation of the proposed MLI was carried out and satisfactory results were obtained. A FPGA controller wass used to achieve MPPT, inverter control as well as islanding detection. The simulation and prototype implementation for an input of 20V dc and 220Vrms output was carried out and satisfactory results were obtained.
The ATPase Activity of Myr3, a Rat Myosin I, Is Allosterically Inhibited by Its Own Tail Domain and by Ca2+ Binding to Its Light Chain Calmodulin*

We purified Myr3 (third unconventional myosin from rat), a mammalian “amoeboid” subclass myosin I, from rat liver. The heavy chain of purified Myr3 is associated with a single calmodulin light chain. Myr3 exhibits K/EDTA-ATPase and Mg-ATPase activity. The Mg-ATPase activity is stimulated by increasing F-actin concentrations in a complex triphasic manner similar to the Mg-ATPase activity of myosin I molecules from protozoa. Although purified Myr3 was observed to cross-link actin filaments, it bound in an ATP regulated manner to F-actin, and no evidence for a nucleotide-independent high affinity actin binding site that could explain the triphasic activation pattern was obtained. Micromolar concentrations of free Ca2+ reversibly inhibit the Mg-ATPase activity of Myr3 by binding to its light chain calmodulin, which remains bound to the Myr3 heavy chain irrespective of the free Ca2+ concentration. Polyclonal antibodies and Fab fragments directed against the tail domain were found to stimulate the Mg-ATPase activity. A similar stimulation of the Myr3 Mg-ATPase activity is observed upon proteolytic removal of the very C-terminal SH3 domain. These results demonstrate that Myr3 is subject to negative regulation by free calcium and its own tail domain and possibly positive regulation by a tail-domain binding partner.
Measurement of the Absolute Branching Fraction of D0 ->K- pi+

We measure the absolute branching fraction for $D0 \to K^{-} \pi^{+}$ using partial reconstruction of $B0bar \to D^{*+} X \ell^{-} \bar{\nu}_{\ell}$ decays. Only the charged lepton and the soft pion from the decay $D^{*+} \to D^{0} \pi^{+}$ are used. Based on a data sample of 230 million BBbar pairs collected at the $\Upsilon(4S)$ resonance with the \babar detector at the PEP-II asymmetric-energy $B$ Factory at SLAC, we obtain ${\cal B}(\Dz \to \Km \pip) = (4.025 \pm 0.038 \pm 0.098)%$, where the first error is statistical and the second error is systematic.
Low-grade osteosarcoma of the jaw.

We describe a case of low-grade osteosarcoma of the jaw. The patient is a 25-year-old woman who presented with large, nontender, slowly progressive, expansile left mandibular mass. X-ray showed a predominantly hypodense mass with erosive growth pattern affecting the angle, posterior body, and ramus of the left mandible. The patient underwent left hemimandibulectomy. The tumor was a white-tan, well-circumscribed, multinodular, firm mass that measure 7.0 cm. Microscopically, the tumor was composed of bland spindle cells, with minimal cellular atypia, absent mitotic figures, very focal osteoid formation with extensive bone destruction, and soft tissue infiltration. Immunhistochemical stains for a large panel of antibodies were noncontributory. At present the patient is alive and well 7 months after surgery.
Identification of a putative cell adhesion domain of uvomorulin.

A rat monoclonal antibody (DECMA‐1) selected against the murine cell adhesion molecule uvomorulin blocks both the aggregation of mouse embryonal carcinoma cells and the compaction of pre‐implantation embryos. However, decompacted embryos eventually become recompacted in the presence of DECMA‐1 and form blastocysts composed of both trophectoderm and inner cell mass. DECMA‐1 also disrupts confluent monolayers of Madin‐Darby canine kidney (MDCK) epithelial cells. DECMA‐1 recognizes uvomorulin in extracts from mouse and dog tissues. Protease digestion of mouse and dog uvomorulin generated core fragments including one of 26 kd which reacted with DECMA‐1. The same 26‐kd fragment is recognized by anti‐uvomorulin monoclonal antibodies which have been obtained from other laboratories and which dissociate MDCK cell monolayers and block the formation of the epithelial occluding barrier. This 26‐kd fragment therefore seems to be involved in the adhesive function of uvomorulin.
[Association of p53 codon 72 polymorphism with genetic susceptibility to hepatocellular carcinoma in Chinese population].

OBJECTIVE A functional single nucleotide polymorphism (SNP) at codon 72 of the gene for p53 protein (p53 R72P) has been implicated in a variety of human cancers, but the relationship between this SNP and hepatocellular carcinoma (HCC) remains obscure despite the fact that the critical role of p53 protein in HCC has been documented. This study was conducted to evaluate the link between the polymorphism with HCC stratified by chronic hepatitis B infection status in a Chinese population. METHODS Four hundred and sixty-nine HCC cases (359 HbsAg-positive, 110 HbsAg-negative) and 567 controls (137 HbsAg-positive, 430 HbsAg-negative) were studied. The p53 genotypes were determined by a PCR based restriction fragment length polymorphism (RFLP) method. RESULTS Overall, no correlation between HCC and the R72P genotypes was found when comparing all cases to controls or when comparing the HbsAg-positive HCC subgroup to controls. However, in HbsAg-negative subjects, the 72P allele was significantly associated with the presence of HCC (P=0.01) and had a higher risk (OR=1.69, 95% CI: 1.25-2.27) of HCC as compared to the 72R allele. By comparison to R/R homozygotes, the R/P heterozygotes and P/P homozygotes had a 1.73-fold (95% CI: 0.96-3.11) and a 3.29-fold (95% CI: 1.58-6.86) increased risk for HCC, respectively. The subjects with the 72P allele and a family history of HCC and those with the 72P allele and male gender also yielded an 11.14-fold (95% CI: 1.62-76.67) and a 9.39 fold (95% CI: 3.08-28.62) increased risk of HCC, respectively. CONCLUSION The P allele of the p53 R72P polymorphism has an increased risk for HCC in HbsAg-negative subjects, and exerts a synergistic influence on the risk for HCC when combined with HCC family history and the male gender.
Individual Phase Current Control With the Capability to Avoid Overvoltage in Grid-Connected Photovoltaic Power Plants Under Unbalanced Voltage Sags

Independent current control of each phase of a three-phase voltage source inverter under unbalanced voltage sags is proposed to effectively meet grid code requirements for grid-connected photovoltaic power plants (GCPPPs). Under current grid codes, GCPPPs should support grid voltages by injecting reactive currents during voltage sags. Such injection must not allow the grid voltages of the nonfaulty phases to exceed 110% of their nominal value. However, grid overvoltages can occur in the nonfaulty phases, especially if the currents injected into the grid by the GCPPP are balanced. Based on a new requirement of the European network of transmission system operators published in 2012, a transmission system operator is allowed to introduce a requirement for unbalanced current injection. In this letter, this grid code is addressed by controlling individual phases and injecting unbalanced currents into the grid during voltage sags. Experimental results from a 2.8-kV.A inverter are presented, confirming the effectiveness of the proposed control method.
Pulsed Atmospheric Pressure Plasma Jet ( PAPPJ )

APPJ technology represents a promising and revolutionary new technology for rapid decontamination of material and personnel. The discharge operates on a feedstock gas ~e.g., He, air, N2 or argon, which flows between an outer, grounded, cylindrical electrode and an inner, coaxial electrode powered at 20kV pulsed high voltage. While passing through the plasma, the feed gas becomes excited, dissociated or ionized by electron impact. Langmuir probe measurements in the jet effluent indicate that the concentration of charged species is relatively low, on the order of ∼8×10-5×10 cm. However, inside the jet the electron density should be much higher, as suggested by the intense atomic lines observed in the optical emission spectrum. Based on the emission spectra, it is estimated that the electron temperature inside the plasma jet averages between 1–2 eV.
Analytical Modeling of Speed Response of Heterojunction Bipolar Phototransistors

This paper describes a new comprehensive analytical charge-control model, which includes all the significant delays associated with heterojunction bipolar phototransistors (HPTs). A minimum number of approximations and assumptions have been made throughout its development. The model is accurate and predictive and provides an excellent insight into the operation of the HPT since the equations developed are based on fundamental charge control of the device operation. Realistic switching results up to 40 Gb/s, which are applicable to optical fiber communications systems, have been obtained, which emphasize the value of the model in the device optimization process
Insulin Degradation by Mononuclear Cells

Mononuclear cells from peripheral blood possess insulin receptors that are altered in number or binding affinity in certain metabolic diseases as obesity. The monocyte, and not the lymphocyte, is the cell with the capacity to specifically bind insulin. Furthermore, this binding appears to mirror the receptor status on such insulin target tissues as liver, muscle, and fat. Since liver, muscle, and fat also degrade insulin, mononuclear cells from the blood of normal volunteers were examined for insulin-degrading activity. Intact cells were incubated with 125I-insulin and the amount of degraded insulin was measured by the trichloroacetic acid-precipitation technique. Insulin-degrading activity increased when the number of cells and the time of incubation were increased. Total insulin binding behaved in a similar fashion. Very little degradation was seen at 4° or 15°. The Km for insulin-degrading activity was 7.03 × 10−8 M. Homogenized mononuclear cells degraded two to five times more insulin than did intact cells and also demonstrated cell concentration, time, and temperature dependence for degradation. The Km of degradation for homogenized mononuclear cells was 2.2 × 108 M. Subcellular fractionation revealed significant degrading activity in the 100,000 × g supernatant, but little activity in the 100,000 × g pellet. A purified lymphocyte preparation did not bind insulin and contained little insulin-degrading activity.
Collaborative Flight and Flow Information Exchange to Achieve Seamless Air Traffic Management Operation

A collaborative environment for system-wide flight and flow information exchange is essential to achieve global seamless air traffic management operation. This collaborative information exchange will provide a shared operational image to all relevant parties in order to achieve seamless operation both in the planning phase and the execution phase. However, the current aviation communication networks and information management systems cannot satisfy the requirement for collaborative information sharing. In this paper, the architecture and the collaborative information exchange technology to support coordination between ground-to-ground and air-to-ground systems are proposed. Moreover, the observations and analysis of validation exercise based on the local evaluation system are reported. Finally, the problems and challenges for constructing the collaborative operating environment through a system-wide information management are analyzed and discussed.
Cost-Efficient Cooperative Sharing of a Complete Wi-Fi Signature Scheme for Indoor Localization in Shopping Malls

Wi-Fi-based indoor localization has drawn much attention since the last decade. However, the current Wi-Fi localization system highly depend on the demanding conditions of the environment, hindering its applications such as in shopping malls, a large, complex but profitable application scenario. To prompt the adoption of Wi-Fi localization system in shopping malls, we propose a coarse-grained Wi-Fi localization system constructed by the shops for mobile phone users at the shop level. The two objectives we pursue of the Wi-Fi localization system are the cost-efficiency, where only minimum number of access points (APs) are deployed, and incentives, where each shop is well-motivated to follow our scheme to install the APs. For the first objective, we propose a dynamic programming to compute the minimum Wi-Fi deployment scheme. For the second objective, we propose a valuation sharing scheme in cooperative game theory to balance the interest of each shop. Our results shed insight on how cost efficiency can be achieved for Wi-Fi localization system and on how to motivate agents to contribute to Wi-Fi localization system.
Alternative Agents to Vancomycin for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections

Resistant gram-positive infections, specifically methicillin-resistant Staphylococcus aureus (MRSA), carry an increased risk for morbidity and mortality. Historically, MRSA has been a cause of nosocomial infections, although recent reports have noted an increased prevalence in community-acquired MRSA infections. Vancomycin is the preferred agent to treat MRSA. However, cases of S. aureus with reduced susceptibility to vancomycin have been reported, prompting the need for alternative treatment options. In this review, we discuss the currently available agents with MRSA activity and those in development. Linezolid and quinupristin/dalfopristin have been demonstrated as effective although potential toxicities must be taken into consideration before their use. Daptomycin, tigecycline, telavancin, and ceftaroline are well tolerated but lack the clinical data to support a superior place in treatment over vancomycin. Several new agents in various stages of development have also demonstrated MRSA activity. Currently, vancomycin remains the gold-standard treatment option for MRSA infections. In situations that limit its use, consideration of patient-specific parameters, cost, and relevant clinical data demonstrating drug safety and efficacy should be employed for the selection of the appropriate alternative agent.
Clinical significance of miR-199 a-5 p expression in non-small cell lung cancer patients

Background: Low miR-199a-5p expression was associated with cancer prognosis. However, its clinical significance in non-small cell lung cancer (NSCLC) is still unclear. This study was aimed to evaluate the prognostic significance of miR-199a-5p in NSCLCs and verified the effects of miR-199a-5p on NSCLC cells. Methods: Radically resected NSCLC tissues and adjacent non-tumor tissues (NTs) were collected from 61 NSCLC patients who underwent lung resection between January 2012 and December 2014. We used quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) assays to detect miR-199a-5p expression. The association of miR-199a-5p expression with clinicopathological factors was statistically analyzed. Effects of miR-199a-5p overexpression on proliferation, apoptosis and invasion on NSCLC cells in vitro were detected. Results: Compared with the adjacent non-tumor group, miR-199a-5p expression was significantly downregulated in NSCLCs (P<0.001). Low miR-199a-5p expression was significantly correlated with the lymph node metastasis, high II+III stage, lymphatic permeation, pleural involvement and vascular invasion. MiR-199a-5p overexpression decreased invasion, proliferation and induced apoptosis in NSCLC cells in vitro. Conclusions: The expression level of miR-199a-5p was significantly downregulated in NSCLC tissues compared with the adjacent non-tumor tissues (P<0.001). Downregulation of miR-199a-5p was correlated with adverse clinical features. MiR-199a-5p could serve as a promising biomarker and therapeutic targets in NSCLC.
A Principal Component Based Haze Masking Method for Visible Images

Land surfaces are commonly obstructed by haze in remote sensing images, which reduces the available land cover information. Haze detection is therefore important for locating, avoiding, or restoring hazy regions. In this letter, a principal component (PC)-based haze masking (PCHM) method is developed for the masking of haze in visible remote sensing images covering land surfaces at middle latitudes. Owing to the evidence of haze in the second PC, the PCHM method results in accurate haze masks. The complete procedure comprises two steps: haze construction and spatial optimization. The validity of the PCHM method is demonstrated through its application to several hazy visible images clipped from Landsat Enhanced Thematic Mapper Plus scenes. The quantitative assessments verify the superiority of the proposed method over the haze optimized transformation method for the production of binary haze masks. In addition, the resulting haze masks are compared with a MODIS cloud product, which further proves the necessity and validity of the proposed method.
Norm Referenced and Criterion Based Measures with Preschoolers

It is becoming increasingly imperative to document child progress within federally funded experimental early education projects. Two major forms of assessment are available: (a) standardized or norm referenced tests, and (b) criterion based measures. Arguments abound concerning the relative advantages and imposed requirements for their use. This study employed both types of measures within a developmentally integrated preschool. Handicapped and nonhandicapped children were given both the norm referenced Gesell Developmental Schedules and the criterion based HICOMP progress measure on a quarterly (10 week) basis. Various scoring methods were employed for both types of tests. Intercorrelations among scoring methods within and between both child groups were computed. Results showed high correlations between norm based and criterion based measures within the handicapped group but not within the nonhandicapped group. The findings suggest that much of the controversy may be avoided if norm based and criterion based measures are appropriately matched and employed in closely monitored child programs.
GISA: A Brazilian platform for autonomous cars trials

According to WHO, traffic safety is one of the major concerns of this decade. Due to this, researchers worldwide aim to reduce the large number of fatalities in traffic accidents. This paper presents GISA as a contribution to this scenario. It consists of a platform for testing autonomous car algorithms. Firstly, some requisites to build an autonomous vehicle are presented, followed by sensors, their placement and ROS middleware. Some tests are presented to check the platform performance, including localization issues and obstacle detection. Results show that GISA is a consistent platform for implementation of autonomous car algorithms.
Commentary: Predicting the unpredictable: the future incidence of variant Creutzfeldt-Jakob disease.

Following publication of the report from the bovine spongiform encephalopathy (BSE) inquiry into the handling of the BSE epidemic in the UK, there has been a considerable loss of public trust in the safety of food products and in the handling of disease outbreaks more generally, highlighted by intense public and media reaction to E-coli, salmonella, foot-and-mouth, and most recently severe acute respiratory syndrome (SARS). Perhaps for this reason, and despite the relatively small numbers of cases, there continues to be substantial public interest in the future course of the variant Creutzfeldt-Jakob disease (vCJD) epidemic. In addition, and again perhaps in part stimulated by the precautionary principle proposed by the BSE inquiry report, there is an ongoing need for updated estimates of the future incidence of vCJD so that public health safety measures (such as the Over Thirty Months Scheme which prevents older cattle from entering the human food supply) can be constantly evaluated. Thus there is a growing number of publications providing such predictions based on the limited case numbers (135 cases to the
Identification and assignment of the human transient receptor potential channel 6 gene TRPC6 to chromosome 11q21→q22

Supported by grants from Telethon-Italy, grant no. E.546 to A.C. , from TelethonItaly, grant no. E.526 and E.C. contracts BMH4-CT96-0338 and BMH4-CT961134 to M.D’U. and by grants from AIRC (Italian Association for Cancer Research) and Telethon-Italy, grant no. E.672 to M.R. The authors gratefully acknowledge Mrs. M. Terracciano and Mrs. A. Torino for excellent technical assistance and the Sequencing Unit Core of Area di Ricerca di Napoli, CNR where the sequencing was performed. M.D’E. and M.S. contributed equally to this work.