Miracle-dz/UniFAR-FTUs huggingface dataset:
Quantitation of Interactive Effects between Anticancer Agents Using SAS

The interactive effects of two anticancer agents are frequently evaluated using three different types of graphs: concentrationeffect curves, isobolograms, or combination index curves. In order to determine the cytotoxicity of the combined agents at an array of combinations, the experimental cytotoxicity data are usually processed by using statistical software and spreadsheet software separately. In general, the use of separate software applications is time-consuming and introduces the risk of errors made during data transfer. To avoid these pitfalls, we developed a SAS based system that processes the raw cytotoxicity assay data and generates three types of graphs and related parameters. The system consists of a series of SAS macros that can be structured in three levels (menu program, main flow macro, and individual function macros) and classified into three categories (data manipulation, model estimation, and graph presentation). Three curves are generated using SAS/GRAPH. It is efficient and convenient for researchers to this system to measure the interactive effects of combinations of two anticancer agents.
MRI/Myelographic Localization of Fistulous Tract in Spinal Dural Arteriovenous Malformations Prior to Arteriography

Objective Our goal was to use currently available imaging methods to localize the fistulous tract of spinal dural arteriovenous malformations (SDAVMs) prior to arteriography. Materials and Methods Two middle-aged men showed MR findings indicative of a SDAVM. In the first patient coronal T2-weighted (T2W) imaging identified the engorged draining radiculospinal vein and traced it back to the intervertebral foramen site where the “nidus” was located. Then, axial T2W imaging was performed at the level of the involved intervertebral foramen. In the second patient MRI failed to demonstrate the nidus; myelography was carried out and showed the course of the abnormal intraspinal vein. Results Successful MR/myelographic demonstration of the nidus (Case 1) or the abnormal intraspinal vein (Case 2) simplified and abbreviated the later studies. Conclusion With MRI and/or myelography we were able to localize the site of the fistulous tract in the two cases of SDAVM prior to spinal arteriography.
Résumés linguistiques de données numériques : interprétabilité et périodicité de séries. (Linguistic summaries of numerical data : interpretability and series periodicity)

Nos travaux s'inscrivent dans le domaine des resumes linguistiques flous (RLF) qui permettent la generation de phrases en langage naturel, descriptives de donnees numeriques, et offrent ainsi une vision synthetique et comprehensible de grandes masses d'information. Nous nous interessons d'abord a l'interpretabilite des RLF, capitale pour fournir une vision simplement apprehendable de l'information a un utilisateur humain et complexe du fait de sa formulation linguistique. En plus des travaux existant a ce sujet sur les composants elementaires des RLF, nous proposons une approche globale de l'interpretabilite des resumes vus comme un ensemble de phrases et nous interessons plus specifiquement a la question de leur coherence. Afin de la garantir dans le cadre de la logique floue standard, nous introduisons une formalisation originale de l'opposition entre phrases de complexite croissante. Ce formalisme nous permet de demontrer que les proprietes de coherence sont verifiables par le choix d'un modele de negation specifique. D'autre part, nous proposons sur cette base un cube en 4 dimensions mettant en relation toutes les oppositions possibles entre les phrases d'un RLF et montrons que ce cube generalise plusieurs structures d'opposition logiques existantes. Nous considerons ensuite le cas de donnees sous forme de series numeriques et nous interessons a des resumes linguistiques portant sur leur periodicite : les phrases que nous proposons indiquent a quel point une serie est periodique et proposent une formulation linguistique appropriee de sa periode. La methode d’extraction proposee, nommee DPE pour Detection of Periodic Events, permet de segmenter les donnees de maniere adaptative et sans parametre utilisateur, en utilisant des outils issus de la morphologie mathematique. Ces segments sont ensuite utilises pour calculer la periode de la serie temporelle ainsi que sa periodicite, calculee comme un degre de qualite sur le resultat renvoye mesurant a quel point la serie est periodique. Enfin, DPE genere des phrases comme « Environ toutes les 2 heures, l'afflux de client est important ». Des experiences sur des donnees artificielles et reelles confirment la pertinence de l'approche. D’un point de vue algorithmique, nous proposons une implementation incrementale et efficace de DPE, basee sur l’etablissement de formules permettant le calcul de mises a jour des variables. Cette implementation permet le passage a l'echelle de la methode ainsi que l'analyse en temps reel de flux de donnees. Nous proposons egalement une extension de DPE basee sur le concept de periodicite locale permettant d'identifier les sous-sequences periodiques d'une serie temporelle par l’utilisation d’un test statistique original. La methode, validee sur des donnees artificielles et reelles, genere des phrases en langage naturel permettant d’extraire des informations du type « Toutes les deux semaines sur le premier semestre de l'annee, les ventes sont elevees ».
Turning induction motors in four poles active magnetic bearings with coupled fluxes

Nowadays, active magnetic bearings (AMBs) can be found operating in several applications. The fabrication of these devices can be considered a mature issue as a consequence of several decades of research and developing. Nevertheless, the related cost of the construction of its parts continues to be high. This is particularly true as the commissioning requires previous information like the machine shaft dimensions where these devices are going to be working. Even more, when there is not an automatic tool to mount their windings, this work continues to be manually. With this in mind, the possibility to use conventional induction motors to reduce the cost of active magnetic bearings is presented in this work. Different to the conventional (AMBs), the magnetic fluxes distribution is based in the coupled one structure as found in a four poles conventional AC motor with distributed windings. Through Finite Elements analysis, a two phase and a three phase cases are considered. Experimental results, using the two phase version, validate this approach.
The relation of depression and anxiety to life-stress and achievement in students.

OBJECTIVES An apparent increase in seriously disturbed students consulting student health services in the UK has led to concern that increasing financial difficulties and other outside pressures may affect student mental health and academic performance. The current research investigated whether student anxiety and depression increases after college entry, the extent to which adverse life experiences contribute to any increases, and the impact of adversity, anxiety and depression on exam performance. METHOD 351 UK-domiciled undergraduates completed questionnaires one month before university entry and mid-course. The Hospital Anxiety and Depression Scale (HADS: Zigmond & Snaith, 1983) was administered at both time points and a modified List of Threatening Experiences (Brugha, Bebbington, Tennant, & Hurry, 1985) was administered mid-course. RESULTS By mid-course 9% of previously symptom-free students became depressed and 20% became anxious at a clinically significant level. Of those previously anxious or depressed 36% had recovered. After adjusting for pre-entry symptoms, financial difficulties made a significant independent contribution to depression and relationship difficulties independently predicted anxiety. Depression and financial difficulties mid-course predicted a decrease in exam performance from first to second year. CONCLUSIONS This is the first study to confirm empirically that financial and other difficulties can increase British students' levels of anxiety and depression and that financial difficulties and depression can affect academic performance. However, university life may also have a beneficial effect for some students with pre-existing conditions. With widening participation in higher education, the results have important implications for educational and health policies.
An Adaptive Observer With Online Rotor and Stator Resistance Estimation for Induction Motors With One Phase Current Sensor

An adaptive observer with online estimation of rotor and stator resistances is considered for induction motors, while only one phase current is measured. Generally, an induction motor drive controller needs at least two phase-current sensors. Nevertheless, failure of one current sensor results in degradation of motor drive performance and reliability, and also state and parameter estimation errors. Furthermore, any controller or observer in induction motor drives should be robust to rotor and stator resistance variations. The proposed observer is capable of concurrent estimation of stator currents and rotor fluxes with online tuning of rotor and stator resistances, while rotor speed and only one phase current are available. Stability and convergence of the observer are analytically verified based on the partial stability theory. The observer equations and adaptation laws can be easily implemented, which makes it attractive for industrial development of fault tolerant drives. A complex programmable logic device is implemented for the experimental setup that controls an intelligent power module including insulated gate bipolar transistors. Extensive simulation and experimental tests verify the asymptotic convergence of the proposed observer.
Identity-Based Key Agreement for Peer Group Communication from Pairings

Some cryptographic schemes based on the bilinear pairings were proposed recently. In this paper, we apply the pairings on elliptic curve and Elliptic Curve Cryptography to the key agreement of dynamic peer group. Each member performs authentication and contributes a secret data to negotiate a group common key by means of a binary key tree. The proposed protocol does not need a dedicated central server to perform the key agreement, and the overhead is distributed among the group members. To provide a secure dynamic group communication, the key renewing mechanism has to be included. While the member joins/leaves, the group session key will be renewed to provide the backward/forward privacy, respectively. The key renewing is much efficient because it is only confined to the keys of the key-path. The proposed protocol is flexible while the change of membership is frequent.
Classification of neurocognitive disorders in DSM-5: a work in progress.

T Neurocognitive Disorders (NCDs) Work Group of the American Psychiatric Association’s (APA) Diagnostic and Statistical Manual of Mental Disorders (DSM-5) Task Force began work in April 2008 on their task of proposing revisions to the criteria for the disorders referred to in DSM-IV as Delirium, Dementia, Amnestic, and Other Cognitive Disorders.1 Over the past 2 years, we have, among ourselves and with input from outside consultants and advisors, worked to develop a draft that was posted on the APA’s Web site www.dsm5. org in February 2010. This draft contained both an overview/rationale for the approach we have taken to date and preliminary criteria for the broadly defined disorders. Without reiterating here all the material posted on the Web site, we will provide our approach to the challenges we faced and some rationale for that approach. We are also pleased to have this opportunity to respond publicly both to the many comments directed to the Work Group on and off the Web site, and to the very thoughtful and constructive commentary provided by Drs. Rabins and Lyketsos in this issue.2 Finally, while this response is directed to the readership of the American Journal of Geriatric Psychiatry, we emphasize that the
CorAIt - A Non-native Speech Database for Italian

English. CorAIt is a non-native speech database for Italian, which is freely accessible online for academic research purposes. It was especially designed to meet the requirements of a larger research project focused on foreign accented Italian speech. The corpus is aimed at providing a uniform collection of speech samples uttered by non-native speakers of Italian. To date, 105 non-native speakers – whose mother tongues are either French, Romanian, Spanish, English, German, or Russian – have been recorded. The corpus includes also a control group made up of 16 Italian speakers. There are almost 8 hours of audio material, both read speech (first and second reading), and spontaneous speech. This paper emphasizes the necessity for this type of database, it describes the steps involved in its construction, and it presents the features of CorAIt. Italiano. CorAIt è un corpus audio di l’italiano L2 liberamente consultabile online per scopi di ricerca scientifica. Il corpus è parte integrante di un progetto di ricerca che affronta l’accento straniero nella lingua italiana da una prospettiva più ampia. E’ stato ideato e costruito con lo scopo di fornire una raccolta uniforme di materiale audio prodotto da parlanti di italiano L2. Ad oggi sono stati registrati 105 parlanti stranieri di madrelingua: francese, romena, spagnola, inglese, tedesca, e russa. In aggiunta, il corpus è dotato di un gruppo di controllo composto da 16 parlanti italiani. Sono disponibili circa 8 ore di registrazioni, sia di parlato letto (prima e seconda lettura) che di parlato spontaneo. L’articolo evidenzia la necessità di costruire questo tipo di database, e descrive la progettazione e le caratteristiche di CorAIt.
The reliability and validity of the Astrand nomogram and linear extrapolation for deriving VO2max from submaximal exercise data.

BACKGROUND While the accepted measure of aerobic power remains the VO2max this test is extremely demanding even for athletes. There are serious practical and ethical concerns in attempting such testing in non-athletic or patient populations. An alternative method of measuring aerobic power in such populations is required. A limited body of work exists evaluating the accuracy of the Astrand-Ryhming nomogram and linear extrapolation of the heart rate/oxygen uptake plot. Issues exist in terms of both equipment employed and sample numbers. METHODS Twenty-five normal subjects (mean age 28.6, range 22-50) completed 52 trials (Bruce treadmill protocol) meeting stringent criteria for VO2max performance. Respiratory gases were measured with a portable gas analyser on a five-sec sample period. The data was analysed to allow comparison of the reliability and validity of linear extrapolations to three estimates of heart rate maximum with the Astrand nomogram prediction. RESULTS Extrapolation was preferable yielding intraclass correlation co-efficients (ICC) of 0.9433 comparable to that of the observed VO2max at 0.9443 and a bias of -1.1 ml x min(-1) x kg(-1) representing a 2.19 percent underestimate. CONCLUSIONS This study provides empirical evidence that extrapolation of submaximal data can be employed with confidence for both clinical monitoring and research purposes. With the use of portable equipment and submaximal testing the scope for future research in numerous populations and non-laboratory environments is considerably increased.
Human Reliability Analysis in Spaceflight Applications, Part 2: Modified CREAM for Spaceflight

Human reliability analysis is a crucial for manned spaceflight success. Cognitive Reliability Error Analysis Model (CREAM) has been developed and used by the nuclear industry in predicting human error. Previously, the authors have calculated the probability error for an International Space Station ingress procedure using performance shaping factors (PSF). In this paper, the procedural risk under both ideal and common conditions using the new spaceflight specific PSFs is calculated. The risk was found to vary from the risk calculated using standard PSFs and to vary greatly depending on the spacecraft specific conditions. Under ideal conditions, the risk was found to be 1 in 88, but under common conditions, the risk was 1 in 3. Then, the new PSFs were used to analyze the impact of the three styles of training used at NASA under common conditions. Of skill‐based training, task‐based training, and knowledge‐based training, the CREAM analysis using the new PSFs showed that skill‐based training resulted in the most significant improvement in the risk of human error, from 1 in 3 to 1 in 11. Copyright © 2013 John Wiley & Sons, Ltd.
Anatomic Guides to Precisely Localize the Zygomatic Branches of the Facial Nerve

Descriptions of superficial anatomic landmarks for the identification of the zygomatic branches of the facial nerve, and their relevance for plastic surgery, are lacking in the literature. This paper provides such a description and discusses its relevance to facial surgery. Materials and Methods:Sixty-six specimens, including the parotid region, from 33 adult cadavers were dissected and studied. All specimens were fixed in formaldehyde, and the superficial tissues were removed and the zygomatic branches of the facial nerve, the parotid gland, the tragus and the lateral palpebral commissure were identified. The vertical and horizontal relationships were recorded and analyzed. Results and Conclusions:A total of 69.7% of the cadavers had two branches, 25.8% had three branches, and 4.5% had a single zygomatic branch. The mean horizontal distance of the zygomatic branch (the most upper one) as it emerged from the anterior border of the parotid gland and the tragus was 30.71 mm, whereas the mean vertical distance of the zygomatic branch from the midpoint between the tragus and the lateral palpebral commissure was 19.29 mm. The branching patterns with the buccal branches were reported. There were no statistical differences between the left and right sides or between the sexes. The zygomatic branches of the facial nerve were always under the oblique line between the tragus and the lateral palpebral commissure and have a close relationship with the buccal branches of the facial nerve under this anatomic landmark. Application of the results in facial surgery is discussed.
A Formally Verified Peak-Power Reduction Technique for Hardware Synthesis from Concurrent Action-Oriented Specifications

High-level Concurrent Action-Oriented Specifications (CAOS) of hardware designs based on concurrent atomic actions can be synthesized into efficient hardware implementations as exemplified by the Bluespec Compiler. However, peak-power aware synthesis has not been available for such compilers. In this paper, we propose a technique for peak-power reduction (without unduly compromising latency) during high-level synthesis from CAOS. We demonstrate the efficacy of our technique through experimental results on some benchmark designs from Bluespec Inc. The proposed technique involves rescheduling of the actions of a design, necessitating the verification of resulting hardware against the results of standard synthesis. Thus, we also formally verify various power-minimized designs to ensure that the proposed technique preserves their correctness while reducing the peak-power.
Bedtime misalignment and progression of breast cancer

Disruption of circadian rhythms, which frequently occurs during night shift work, may be associated with cancer progression. The effect of chronotype (preference for behaviors such as sleep, work, or exercise to occur at particular times of day, with an associated difference in circadian physiology) and alignment of bedtime (preferred vs. habitual), however, have not yet been studied in the context of cancer progression in women with breast cancer. Chronotype and alignment of actual bedtime with preferred chronotype were examined using the Morningness–Eveningness Scale (MEQ) and sleep-wake log among 85 women with metastatic breast cancer. Their association with disease-free interval (DFI) was retrospectively examined using the Cox proportional hazards model. Median DFI was 81.9 months for women with aligned bedtimes (“going to bed at preferred bedtime”) (n = 72), and 46.9 months for women with misaligned bedtimes (“going to bed later or earlier than the preferred bedtime”) (n = 13) (log rank p = 0.001). In a multivariate Cox proportional hazard model, after controlling for other significant predictors of DFI, including chronotype (morning type/longer DFI; HR = 0.539, 95% CI = 0.320–0.906, p = 0.021), estrogen receptor (ER) status at initial diagnosis (negative/shorter DFI; HR = 2.169, 95% CI = 1.124–4.187, p = 0.028) and level of natural-killer cell count (lower levels/shorter DFI; HR = 1.641, 95% CI = 1.000–2.695, p = 0.050), misaligned bedtimes was associated with shorter DFI, compared to aligned bedtimes (HR = 3.180, 95% CI = 1.327–7.616, p = 0.018). Our data indicate that a misalignment of bedtime on a daily basis, an indication of circadian disruption, is associated with more rapid breast cancer progression as measured by DFI. Considering the limitations of small sample size and study design, a prospective study with a larger sample is necessary to explore their causal relationship and underlying mechanisms.
The maintenance of self‐replicating plasmids in Saccharomyces cerevisiae: Mathematical modelling, computer simulations and experimental tests

A distributive model has been constructed to describe the maintenance of the native 2 μm and 2 μm‐based plasmids in the yeast Saccharomyces cerevisiae. This model includes elements which represent the influence of selection, segregation, replication and amplification on plasmid stability. A computer program has been written in TURBO PASCAL to implement the model and a number of simulation experiments have been carried out. These simulations permitted the choice of a form of the model which is compatible with the available experimental evidence. The form chosen involves an amplification system in which the RAF gene product binds to the Rep1/Rep2 dimer to prevent the latter acting to repress the activity of the FLP gene. At the same time an upper limit (or ‘ceiling’) was imposed on the number of plasmid molecules able to replicate. Maternal bias was accommodated by ‘tagging’ a small proportion of molecules for inheritance by the mother nucleus and these tags being removed (or ‘cleared’) by the Rep1/Rep2 dimers. This final form of the model makes specific predictions about the stability of 2 μm and YEp plasmids in yeast populations and about the distribution of plasmid copy number between cells in such populations. The predictions on stability have been subjected to experimental test and results provide good support for the model.
Association between the metabotropic glutamate receptor7 rs3749380 polymorphism and methylphenidate treatment outcome in children with ADHD

Objective: Attention-deficit/hyperactivity disorder (ADHD) is a heritable neurodevelopmental disorder characterized by inattention, disorganization, and/or hyperactivity-impulsivity. This study investigated the association between the metabotropic glutamate receptors (GRM) 7 rs3749380 polymorphism genotypes and subjective/objective treatment responses to methylphenidate (MPH) in Korean children with ADHD. Methods: This study enrolled 86 medication-naive children with ADHD in an open-label 8-week trial of MPH. The subjects were genotyped and then evaluated using the ADHD Rating Scale (ARS), the Continuous Performance Test (CPT) and the Clinical Global Impression Scale (CGI) before and after treatment. Results: After 8-week MPH treatment, children with the GRM7 rs3749380 polymorphism T/T genotype had a different response in terms of visual response times and auditory commission errors on the CPT than C/C or C/T genotype groups. Conclusions: These results suggest that the GRM7 rs3749380 polymorphism is associated with the response of MPH in patients with ADHD. Further studies, including replication of our findings using a control or comparison group and a larger sample, are warranted to evaluate the association between the GRM7 genes and treatment responses to MPH in subjects with ADHD.