Miracle-dz/UniFAR-FTUs huggingface dataset:
The Persian version of the centrality of event scale (CES): Assessment of validity and reliability among Iranian university students

Event centrality, the extent to which an experience is perceived as a central event in one's life, has been found to be a strong correlate of posttraumatic stress disorder (PTSD). The centrality of event scale (CES) is commonly used in different conditions and cultures to measure trauma‐related effects. However, the psychometric properties of this scale have not been investigated in the Iranian context.
Title: Blood flow restricted exercise training: Perspectives of people with chronic obstructive pulmonary disease and health professionals

Objective This descriptive qualitative study explored perspectives of people with chronic obstructive pulmonary disease (COPD) and health professionals concerning blood flow restricted exercise (BFRE) training. Methods People living with COPD and health professionals (exercise physiologists, physiotherapists, and hospital-based respiratory nurses and doctors) participated in interviews or focus groups, which included information about BFRE training and a facilitated discussion of positive aspects, barriers and concerns about BFRE training as a possible exercise-based intervention. Sessions were audio-recorded, and transcript data analysed using inductive content analysis. Results Thirty-one people participated (people with COPD n = 6; health professionals n = 25). All participant groups expressed positive perceptions of BFRE as a potential alternative low-intensity exercise mode where health benefits might be achieved. Areas of overlap in perceived barriers and concerns included the need to address the risk of potential adverse events, suitability of training sites and identifying processes to appropriately screen potential candidates. Discussion While potential benefits were identified, concerns about determining who is safe and suitable to participate, delivery processes, health professional training and effects on a variety of health-related outcomes need to be addressed before implementation of BFRE training for people with COPD.
Genetic Evidence for Congenital Vascular Disorders in Patients with VACTERL Association

Abstract Introduction The VACTERL association is a rare malformation complex, showing at least three anomalies of the following organ systems: vertebra, anorectum, heart and vessels, trachea and esophagus, genitourinary tract, and limbs. In addition to a multifactorial event, congenital vascular disorders are also discussed as triggers for the VACTERL association. The aim of this study was to determine whether there is a genetic background for vascular disorders triggering VACTERL association. Materials and Methods We performed a functional analysis on whole exome sequencing data of 21 patients with VACTERL or VACTERL-like phenotype using the online analysis tool “Database for Annotation, Visualization and Integrated Discovery (DAVID) v6.8. ” The study was approved by the institutional ethics committee (approval no. 026–13). Written informed consent was obtained from all patients or their parents. Results We identified a total of 86 genetic variants (in 75 genes) classified as damaging (including probably damaging missense, nonsense, and frameshift variants), which are associated to cardiovascular development. Each investigated patient showed at least one damaging variant in genes associated to cardiovascular development. These variants were further reduced by significance in cardiovascular development to 39 genetic variants (in 33 genes). Of note, a pair of siblings, both presenting with cardiac and renal defects, had the same damaging variant in two different genes. Conclusion Our results indicate a genetic background for congenital vascular disorders in patients with VACTERL association. In line with the literature, our data suggest that genetic mutation led to vascular diseases, which in turn may cause malformations similar to the VACTERL association.
Biosynthesis, characterisation and antimicrobial activity of zinc oxide and nickel doped zinc oxide nanoparticles using Euphorbia abyssinica bark extract

Abstract Biosynthesis of metallic oxide nanoparticles is being used and preferred over physical and chemical methods of synthesis since it is simple, inexpensive, environmentally friendly, and green. The aim of this study was to synthesise ZnO and nickel doped ZnO nanoparticles using Euphorbia abyssinica bark extract for antimicrobial activity studies via agar disk diffusion method against some selected microbes. The synthesised nanoparticles were characterised using X‐ray diffraction (XRD), ultraviolet–visible spectroscopy, and Fourier transform infrared spectroscopy. The study results revealed that the biosynthesised nanoparticles had good crystalline nature, with crystal sizes in the range of nanoparticles and structures of hexagonal wurtzite. Both undoped ZnO and nickel doped ZnO nanoparticles demonstrated antibacterial and antifungal activity against four bacterial strains and two fungal genus. Generally, nickel doped ZnO NPs were found to possess more antimicrobial activities than undoped ZnO NPs. Specially, 4% and 5% nickel doped ZnO NPs showed significantly enhanced activity against Enterococcus faecalis, Staphylococcus aureus, Aspergillus and Fusarium.
Paper No P30: Heterogeneous Plated Metals for Display Elements and Technologies of High Reliability

This article describes the application of advanced technologies for up‐to‐date display systems. A method for manufacturing of holographic films with high runability for roll‐to‐roll technology is considered. The way for improving the properties of the filters, optical phase retarders, wave plates and other using nanotrench filling technology is proposed. The use of nanocomposite materials for microelectromechanical systems of high reliability and their application to improve the mechanical properties of movable micromirror arrays, switches, microactuators are investigated.
KATNB1 is a master regulator of multiple katanin enzymes in male meiosis and haploid germ cell development.

Katanin microtubule severing enzymes are critical executers of microtubule regulation. Here, we have created an allelic loss-of-function series of katanin regulatory B-subunit KATNB1 in mice. We reveal KATNB1 is the master regulator of all katanin enzymatic A-subunits during mammalian spermatogenesis, wherein it is required to maintain katanin A-subunit abundance. Our data shows complete loss of KATNB1 from germ cells is incompatible with sperm production, and we reveal multiple new spermatogenesis functions for KATNB1, including critical roles in male meiosis, in acrosome formation, in sperm tail assembly, in regulating both the Sertoli and germ cell cytoskeletons during sperm nuclear remodelling and in maintaining seminiferous epithelium integrity. Collectively, our findings reveal that katanins are able to differentially regulate almost all key microtubule-based structures during mammalian male germ cell development, through the complexing of one master controller, KATNB1, with a 'toolbox' of neofunctionalized katanin A-subunits.
The role of informational feedback as a game mechanic on user perceptions, attitudes and the intention to continue using a gamified Health Behaviour Change Support System

Abstract Gamification's widespread application across industries has demonstrated its usefulness as a user engagement strategy. In the healthcare sector, the impact of lifestyle diseases has seen the need for modifying health-related behaviours. Health Behaviour Change Support Systems (HBCSS) enhanced with gamification features seek to help users achieve their health related goals. Adapting the Technology Acceptance Model, the role of informational feedback as a game mechanic in influencing perceptions, attitudes and continued usage intentions towards the gamified HBCSS is assessed. The results show a strong influence of attitude towards informational feedback afforded on the continued use intentions of the user.
High‐Resolution Exposomics and Metabolomics Reveals Specific Associations in Cholestatic Liver Diseases

Progress in development of prognostic and therapeutic options for the rare cholestatic liver diseases, primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC), is hampered by limited knowledge of their pathogeneses. In particular, the potential role of hepatotoxic and/or metabolism‐altering environmental chemicals in the pathogenesis of these diseases remains relatively unstudied. Moreover, the extent to which metabolic pathways are altered due to ongoing cholestasis and subsequent liver damage or possibly influenced by hepatotoxic chemicals is poorly understood. In this study, we applied a comprehensive exposomics‐metabolomics approach to uncover potential pathogenic contributors to PSC and PBC. We used untargeted high‐resolution mass spectrometry to characterize a wide range of exogenous chemicals and endogenous metabolites in plasma and tested them for association with disease. Exposome‐wide association studies (EWAS) identified environmental chemicals, including pesticides, additives and persistent pollutants, that were associated with PSC and/or PBC, suggesting potential roles for these compounds in disease pathogenesis. Metabolome‐wide association studies (MWAS) found disease‐associated alterations to amino acid, eicosanoid, lipid, co‐factor, nucleotide, mitochondrial and microbial metabolic pathways, many of which were shared between PSC and PBC. Notably, this analysis implicates a potential role of the 5‐lipoxygenase pathway in the pathogenesis of these diseases. Finally, EWAS × MWAS network analysis uncovered linkages between environmental agents and disrupted metabolic pathways that provide insight into potential mechanisms for PSC and PBC. Conclusion: This study establishes combined exposomics‐metabolomics as a generalizable approach to identify potentially pathogenic environmental agents and enumerate metabolic alterations that may impact PSC and PBC, providing a foundation for diagnostic and therapeutic strategies.
Occurrence and spatial distribution of triatomines (Hemiptera: Reduviidae) in the urban area of the municipality of Montes Claros, Northern Minas Gerais, Brazil

The north of the Brazilian state of Minas Gerais is classified as an area of high risk of vectorial transmission of Chagas disease (CD) or of reestablishing transmission in the home, but the Chagas disease control programme is disjointed. The study evaluated the occurrence, natural infection and the spatial distribution of species of triatomines associated with climatic variations in the urban area of Montes Claros, a municipality endemic to CD in the north of Minas Gerais, Brazil. Triatomine data were obtained from passive entomological surveillance actions of the Chagas Disease Control Program (Programa de Controle de Doença de Chagas—PCDCh), registered by the Zoonosis Control Center (Centro de Controle de Zoonoses—CCZ) from 2009 to 2019. A total of 277 triatomines belonging to eight species were collected, and of these, 203 insects were examined. It was found that 46.2% of triatomines were captured inside the home and 8.3% around the home. The natural infection rate was 6.9%; 14 specimens showed natural infection by Trypanosoma cruzi (12 females and 2 males), and of these, 13 were found in the home and one in an uninformed location. The number of triatomine records collected was significantly higher in the month of September (p = .01), and there was an inverse correlation between the number of triatomines and the relative humidity of the air (p < .001). It was verified that the highest triatomine densities are located in transition areas between urban infrastructure (32.12%) and pasture (25.72%). The diversity of species of triatomines infected with T. cruzi in residential units in urban areas in the municipality of Montes Claros is worrying, as it suggests a potential risk of transmission of the parasite to domestic animals and humans.
Silibinin loaded inhalable solid lipid nanoparticles for lung targeting

Abstract Aim In the current study, efforts are being made to prepare Inhalable Silibinin loaded solid lipid nanoparticles (SLNs) with narrow size distribution with improved bioavailability. Methods SLNs were formulated by high shear homogenisation method SLNs were characterised, including Differential Scanning Calorimetry (DSC), Fourier transform infra-red spectroscopy (FTIR), particle size analysis, entrapment efficiency with Aerodynamic behaviour. The MTT assay was performed against A549 cell line, to measure their anticancer cell activity with In vivo study. Results Optimized formulation exhibited spherical surface with a mean particle size of 221 ± 1.251 nm, PI of 0.121 ± 0.081, zeta potential of −4.12 ± 0.744. Aerodynamic behaviour such as Mass median aerodynamic diameter (MMAD) and Geometric size distribution (GSD) were found to be 5.487 ± 0.072 and 2.321 ± 0.141 respectively proved formulation is suitable for inhalation. In vitro cellular efficacy against A549 cells, revealed that the optimised formulations were more effective and potent. Conclusion The Inhalable SLNs approach was successfully engineered and administered to the lungs safely without causing any problems.
Fiber Bragg grating sensors for monitoring of wind turbine blades

Fiber Bragg grating sensor arrays can be used to monitor the mechanical behavior of rotor blades of wind turbines. In order to investigate how stable and reliably work such sensors, different fiber Bragg gratings were embedded into textilereinforced composite. Long-term temperature and tensile (fatigue) tests have been carried out with composite structure specimens. This paper reports on selected results of the tests and discusses important reliability aspects with regard to the fiber design and the fiber material.
Direct visualization of magnetic domains and moiré magnetism in twisted 2D magnets

Description Imaging twisty magnets Twisting monolayers of graphene with respect to each other has led to a number of unusual correlated states. This approach has inspired researchers to try their hand at twisting two-dimensional (2D) magnets, but such experiments have proven a difficult challenge. Song et al. made structures out of layers of the 2D magnet chromium triiodide with a small twist angle (see the Perspective by Lado). Using nitrogen vacancy centers in diamond as a magnetometer, the authors imaged the magnetic domains in both twisted monolayer and twisted trilayer structures. For twisted trilayers, a periodic pattern of ferromagnetic and antiferromagnetic domains was revealed. —JS Nitrogen vacancy center magnetometry reveals the magnetic domains of twisted monolayer and trilayer structures of CrI3. Moiré superlattices of twisted nonmagnetic two-dimensional (2D) materials are highly controllable platforms for the engineering of exotic correlated and topological states. Here, we report emerging magnetic textures in small-angle twisted 2D magnet chromium triiodide (CrI3). Using single-spin quantum magnetometry, we directly visualized nanoscale magnetic domains and periodic patterns, a signature of moiré magnetism, and measured domain size and magnetization. In twisted bilayer CrI3, we observed the coexistence of antiferromagnetic (AFM) and ferromagnetic (FM) domains with disorder-like spatial patterns. In twisted double-trilayer CrI3, AFM and FM domains with periodic patterns appear, which is in good agreement with the calculated spatial magnetic structures that arise from the local stacking-dependent interlayer exchange interactions in CrI3 moiré superlattices. Our results highlight magnetic moiré superlattices as a platform for exploring nanomagnetism.
A click chemistry approach to pleuromutilin derivatives, evaluation of anti-MRSA activity and elucidation of binding mode by surface plasmon resonance and molecular docking

Abstract Novel series of pleuromutilin analogs containing substituted 1,2,3-triazole moieties were designed, synthesised and assessed for their in vitro antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA). Initially, the in vitro antibacterial activities of these derivatives against 4 strains of S. aureus (MRSA ATCC 43300, ATCC 29213, AD3, and 144) were tested by the broth dilution method. Most of the synthesised pleuromutilin analogs displayed potent activities. Among them, compounds 50, 62, and 64 (MIC = 0.5∼1 µg/mL) showed the most effective antibacterial activity and their anti-MRSA activity were further studied by the time-killing kinetics approach. Binding mode investigations by surface plasmon resonance (SPR) with 50S ribosome revealed that the selected compounds all showed obvious affinity for 50S ribosome (KD = 2.32 × 10−8∼5.10 × 10−5 M). Subsequently, the binding of compounds 50 and 64 to the 50S ribosome was further investigated by molecular modelling. Compound 50 had a superior docking mode with 50S ribosome, and the binding free energy of compound 50 was calculated to be −12.0 kcal/mol. Graphical Abstract
Neural Representations of the Committed Romantic Partner in the Nucleus Accumbens

Having an intimate romantic relationship is an important aspect of life. Dopamine-rich reward regions, including the nucleus accumbens (NAcc), have been identified as neural correlates for both emotional bonding with the partner and interest in unfamiliar attractive nonpartners. Here, we aimed to disentangle the overlapping functions of the NAcc using multivoxel pattern analysis, which can decode the cognitive processes encoded in particular neural activity. During functional MRI scanning, 46 romantically involved men performed the social-incentive-delay task, in which a successful response resulted in the presentation of a dynamic and positive facial expression from their partner and unfamiliar women. Multivoxel pattern analysis revealed that the spatial patterns of NAcc activity could successfully discriminate between romantic partners and unfamiliar women during the period in which participants anticipated the target presentation. We speculate that neural activity patterns within the NAcc represent the relationship partner, which might be a key neural mechanism for committed romantic relationships.
Rank Statistics and Bootstrap: A More Precise Evaluation of the 95th Percentile in Nuclear Safety LB-LOCA Calculations

In 1988, since the revision of the 10 CFR50.46, the best estimate codes may be used in safety demonstration and licensing, provided that uncertainties are added to the relevant output parameters before comparing them with the acceptance criteria. The uncertainty of output parameters is coming principally from the lack of knowledge of the input parameters (initial and boundary conditions of the calculated transient, empirical models of the code, etc.). In the safety analysis of the large break loss of coolant accident (LB-LOCA), for a best-estimate analysis, it was decided that the acceptance criteria should not be exceeded by the 95th percentile estimated with a high degree of confidence. Best-estimate plus uncertainty (BEPU) analysis of the LB-LOCA allows significant margin gains. Therefore the nuclear industry develops and uses widely this type of analysis for power uprating, longer fuel cycles, fuel design etc. It appeared necessary to IRSN, technical support of the French Safety Authority, to get more insight to these strategies. The assessment of the 95th percentile can be made in three steps: 1. The definition and the evaluation of uncertainties of the input parameters. 2. The modelling and understanding of the output parameters. 3. The evaluation of the 95th percentile with a high degree of confidence. This paper presents and shows two new methods of how to deal with the third point. The standard approach is the use of a non-parametric approach called the Wilks’ formula which requires only 59 calculations to get a majorant of the 95th percentile with a 95% degree of confidence. This method was applied in the 90’s when the calculation resources were not sufficient to perform many calculations in a reasonable time. However, at the present time, the growth of computer power and the fall in prices allow to run many more calculations in the same physical time. We propose to use rank statistics or bootstrap to estimate the 95th percentile with a high confidence level, using some hundreds of calculations. This paper presents the results of the LOFT (Loss-of-Fluid Test) loss of coolant experiment L2-5 using these new methodologies. LOFT L2-5 was the subject of the former ISP 13 and the ongoing BEMUSE international problem. The output parameter is the second maximum peak cladding temperature of the fuel. The best estimate code used is CATHARE2 V2.5. Rank statistics and bootstrap improve the information on the estimation of the 95th percentile: a higher degree of confidence, a more precise estimation etc.Copyright © 2006 by ASME
Tetrahydrocannabinol fails to reduce hair pulling or skin picking: results of a double-blind, placebo-controlled study of dronabinol

Body-focused repetitive behaviors (BFRBs) such as trichotillomania and skin picking disorder are associated with decreased self-esteem and poor quality of life. The objective of this study was to evaluate dronabinol, a cannabinoid agonist, for the reduction of BFRB symptoms. Fifty adults with either trichotillomania (n = 34) or skin picking disorder (n = 16) were recruited for a randomized, double-blind, placebo-controlled study. Participants received 10-week treatment with dronabinol (5–15 mg/day) or placebo. The primary efficacy outcome measure was the change on the clinician-rated National Institute of Mental Health scale for hair pulling or skin picking. Both dronabinol and placebo treatment were associated with significant reductions in BFRB symptoms. Dronabinol did not significantly separate from placebo on any efficacy measure. At week 10, 67% of the treatment group were classified as responders (Clinical Global Impressions-Improvement Score of very much or much improved) compared to 50% in the placebo group (P value = 0.459). This study assessed the efficacy of dronabinol, a synthetic form of tetrahydrocannabinol, in the treatment of BFRBs, and found no differences in symptom reductions between dronabinol and placebo.
Investigating personal and clinical recovery processes in people with first episode psychosis

Schizophrenia is a serious mental illness characterized by a range of symptoms such as distortions in reality, emotional abnormalities and deficits in cognition. Recovery from severe mental illness can be conceptualized in a number of ways. Clinical recovery has a focus on symptoms and functioning whilst personal recovery describes the process of developing new meaning and purpose in life beyond mental illness.