Miracle-dz/UniFAR-FTUs huggingface dataset:
Neutrophilic leucocytosis induced by granulocyte colony‐stimulating factor and interleukin‐6 in canine primary lung adenocarcinoma

Abstract Background Neutrophilic leucocytosis as a paraneoplastic syndrome may occur in dogs with lymphoma, renal carcinoma, rectal polyps and metastatic fibrosarcoma. However, the information on canine lung adenocarcinoma with neutrophilic leucocytosis is lacking. Objective This study aimed to describe the clinical features and cytokine profiles of canine patients with primary lung adenocarcinoma and neutrophilic leucocytosis. Methods Two dogs (cases #1 and #2), each with a solitary lung adenocarcinoma, were included. Both cases had leucocytosis and underwent lung lobectomy. The resected tumours were analysed for the expression of granulocyte colony‐stimulating factor (G‐CSF), granulocyte macrophage colony‐stimulating factor (GM‐CSF) and interleukin‐6 (IL6) by quantitative real‐time PCR compared with normal lung tissues. Results At the initial examination, neither patient had any clinical signs or fever. White blood cell count (WBC) was 58,300/μl and 32,900/μl in cases #1 and #2, respectively. The gene expression of G‐CSF increased 6.7‐and 19.7‐fold in cases #1 and #2, respectively. The gene expression of IL6 markedly increased (30‐fold) in case #1, whereas it increased slightly (1.9‐fold) in case #2. On the other hand, that of GM‐CSF was slightly changed in both cases. The WBC count postoperatively decreased to within the normal range in both cases. The postoperative survival times were 347 and 118 days in cases #1 and #2, respectively. Conclusions This study describes G‐CSF and IL6 producing lung adenocarcinoma associated with neutrophilic leucocytosis in dogs. Canine patients with pulmonary adenocarcinomas that have elevated G‐CSF and IL6 levels may have a guarded prognosis. Further investigations are needed to clarify the prognosis of canine cytokine‐producing lung adenocarcinoma.
Improved Lebesgue Indicator-Based Evolutionary Algorithm: Reducing Hypervolume Computations

One of the major limitations of evolutionary algorithms based on the Lebesgue measure for multi-objective optimization is the computational cost required to approximate the Pareto front of a problem. Nonetheless, the Pareto compliance property of the Lebesgue measure makes it one of the most investigated indicators in the designing of indicator-based evolutionary algorithms (IBEAs). The main deficiency of IBEAs that use the Lebesgue measure is their computational cost which increases with the number of objectives of the problem. On this matter, the investigation presented in this paper introduces an evolutionary algorithm based on the Lebesgue measure to deal with box-constrained continuous multi-objective optimization problems. The proposed algorithm implicitly uses the regularity property of continuous multi-objective optimization problems that has suggested effectiveness when solving continuous problems with rough Pareto sets. On the other hand, the survival selection mechanism considers the local property of the Lebesgue measure, thus reducing the computational time in our algorithmic approach. The emerging indicator-based evolutionary algorithm is examined and compared versus three state-of-the-art multi-objective evolutionary algorithms based on the Lebesgue measure. In addition, we validate its performance on a set of artificial test problems with various characteristics, including multimodality, separability, and various Pareto front forms, incorporating concavity, convexity, and discontinuity. For a more exhaustive study, the proposed algorithm is evaluated in three real-world applications having four, five, and seven objective functions whose properties are unknown. We show the high competitiveness of our proposed approach, which, in many cases, improved the state-of-the-art indicator-based evolutionary algorithms on the multi-objective problems adopted in our investigation.
Travel and Car Ownership of Residents near New Suburban Metro Stations in Shanghai, China

Large cities in China are building extensive rail transit systems in combination with transit-oriented development in suburban areas, so that public transportation can play a leading role in supporting rapid urban expansion. Shanghai, China has been a leader in this planning approach. Shanghai's experience can be valuable for other cities facing similar pressures of urbanization, suburbanization, and motorization while striving to improve livability and reduce greenhouse gas emissions. To gain useful insights from Shanghai, a travel survey of residents in a recently developed suburban metro station area was conducted to examine how the city's mass rapid transit (MRT) has influenced residents’ travel and car ownership. With statistical methods, including logistic regression, it was found that (a) MRT was generally adequate in supporting the station area's economic relationships with the central city and local employment locations; (b) a high percentage of residents intended to commute by the MRT when they moved to the suburban station area, and their original intention positively influenced their current travel and car ownership; and (c) rail transit may help temporarily reduce the pace of motorization in households near suburban metro stations by delaying a car purchase and lowering the probability of car use in commuting. However, it was also found that car ownership had been increasing quite rapidly despite the positive effects of a much expanded and improved metro system, and that once a person owned a car, he or she would most likely drive to work.
Integrated scheduling of production and distribution operations: A review

There are many practical production systems with distribution operations where finished jobs are transferred from supplier to the customer by transporters. In these systems, the coordination of production and logistics operations can help to improve overall system performance and reduce the total operation cost. This paper focuses on two categories of integrated scheduling problems. One is Integrated Scheduling of Production-Distribution Problems (ISPDP) and the other is Integrated Scheduling of Production-Inventory-Distribution Problems (ISPIDP). This paper presents a review of the state-of-the-art articles and suggests the corresponding further research directions for the above two categories of integrated scheduling problems.
Calibrating Detailed Building Energy Simulation Programs with Measured Data—Part II: Application to Three Case Study Office Buildings (RP-1051)

The companion paper proposed a general methodology of calibrating detailed building energy simulation programs to performance data that also allowed the determination of the prediction uncertainty of intended energy conservation measures. The methodology strived to provide a measure of scientific rigor to the process of calibration as a whole, which has remained an art form with no clear consensus guidelines despite being followed by numerous professionals for several decades. The proposed methodology, while providing a clear structure consistent with that adopted in more mature scientific fields, also uses expert domain knowledge and is flexible enough to satisfy different users with different personal preferences and biases. This paper attests to the overall validity of the methodology by presenting the results of applying it to three case study office buildings—two synthetic and one actual. Conclusions on various variants of the overall calibration methodology are presented, along with guidelines and a summary of lessons learned on how to implement such a calibration methodology. Future research needed prior to implementation in commercial hourly detailed simulation programs is also identified.
DNA Barcoding of 15 Species of African Saturniidae (Lepidoptera) across 12 Genera Reveals High Incidence of Non-Monophyly

: African Saturniidae (Lepidoptera) been poorly described despite their nutritional and economic significance in Southern Africa. DNA barcodes for 15 species across 12 genera were generated as a starting point to create a reference sequence library for African Saturniidae. Phylogenetic clustering and genetic divergence estimates were used to assess patterns of genetic diversity in each genus, including all sequences available on BOLD Systems. Cases of polyphyletic and pa-raphyletic species affected 81% of the dataset. Taxonomic misidentifications, clerical and laborato-rial errors, introgression, hybridization and incomplete lineage sorting may contribute to explain these results. We propose that the dataset available for African Saturniidae does not correctly represent the genetic diversity of a high proportion of the taxa in the family.
Taking “Thanks” for Granted: A Cross-Cultural Exploration of Gratitude in the UK and Australia

Examinations of the influence of culture on how gratitude is experienced are sparse, as are studies that simultaneously explore developmental differences in understandings of gratitude. This paper presents three studies that examine whether perceptions and experiences of gratitude differ across children, adolescents and adults in two individualistic, WEIRD and Commonwealth cultures—Australia and the UK. Studies 1a (N = 88, ages 17–39) and 1b (N = 77, ages 17–25) provide initial insights into “features of gratitude” in Australia through two stages of a prototype analysis. These features are compared to a previous prototype study of gratitude in the UK, alongside a further comparison to the US. Study 2 employs vignettes to examine how perceptions of the benefactor, benefit and mixed emotions influence the degree of gratitude experienced across adolescents and adults in Australia (N = 1937, ages 11–85), with a comparison to the UK (N = 398, ages 12–65). In Study 3, factors examined in Study 2 are adapted into accessible story workbooks for younger children (Australia N=135, ages 9–11; UK N=62, ages 9–11). Results across these studies demonstrate similarities and differences in understandings and experiences of gratitude across cultures. While adults across Australia and the UK responded similarly to gratitude scenarios, cross-cultural differences are observed between children and adolescents in these two countries. Developmental differences are noted in relation to more sophisticated reasoning around gratitude, such as recognition of ulterior motives. These findings highlight the need for gratitude research and interventions to be cross-culturally, and developmentally, responsive.
Convolutional neural network in predicting electrocardiogram

With the rapid development of machine learning, an increasing number of domains begin to utilize machine learning methods to simplify part of assignments, which can relieve humans' stress. In traditional domains, like medicine, machine learning methods have great potential to play a significant role in detecting diseases. Some machine learning methods have been deployed to analyze electrocardiograms (ECG) because of the impressive accuracy and speediness, which is meaningful and convenient to the medical domain. Detecting disease in ECG accurately is beneficial to prevent and cure some fatal diseases, which may save thousands of lives. In this paper, the machine learning method is used to detect Atrial fibrillation (AF), a severe heart disease damaging people's health. The model used in this paper is Convolutional Neural Network (CNN), a deep learning model. Apart from building a model to detect AF, this paper will also explore and extend the possibility of using CNN in dealing with one-dimensional data. After dealing with a large amount of original ECG data and feed them with labels to the CNN model with some specific parameters adjusted manually, the CNN model with 91.8% accuracy is trained and can be used on some specific occasions to find exceptions of the heart.
"Times for Peaks of Stress in Quadriceps Muscles During the Force-Velocity Test"

During the Force-Ve-locity Test. Biomed J Sci & Tech Res 39(2)-2021. The aim of this study was to examine the surface Electromyogram (EMG) power spectral during an intermittent test with increasing intensity. Methods: Eighteen sedentary participants (age, 25 ± 4 years; height, 181 ± 3 cm, and weight, 77 ± 7 kg) completed two tests each: a maximum test to determine their physical fitness and a Force-Velocity test (FVt) to examine the EMG evolution of three su perficial quadriceps muscles [anterior (RA), Vastus Lateralis (VL), Vastus Medialis (VM)] at each sprint. Results: The increases of the root-mean-square (RMS in arbitrary unit) and mean power frequency (MPF in HZ) of EMG signal were observed for all sprints in RA, VL, and VM. Rapids increase of RMS and MPF up to 4-5 th seconds and a plateau or decline towards the 6 second were observed. While for RMS these increases were similar and larger for RF and VL compared to that of VM, for MPF, the result was opposite. We showed early and great implication of RF and VL during rapids actions as sprints on bicycle with slow and low contribution of VM important to the maintenance of effort. It would be important to advise a particular training of the RF and the VL in the cyclists to improve the speed of reaction and, of the VM for the maintenance of this speed. Conclusion: We observed similar times for peaks of stress in surface quadriceps muscles at all sprints despite the increase of power output.
Shifting beach wrack composition in the SW Baltic Sea and its effect on beach use

Beach visitors rate beach quality in large part by its appearance. Removal of natural beach litter (called beach wrack) has, therefore, high priority for beach managers in coastal areas dependent on revenues from tourism. Focusing on the German Baltic Sea coast, the amount of beach wrack has increased by a factor of approximately 3.4 between 1977 and 2012/2013. At the same time, the composition of macrophyte communities underwent a severe change from late successional stages (eelgrass and bladder wrack) toward more ephemeral communities. Correspondingly, the contribution of bladder wrack to seaweed litter alone dropped from 75% in 1977 to 18.1% today, while the contribution of ephemeral and nutrient-opportunistic seaweeds increased by a factor larger than 6.2 to approximately 44%. Such seaweed opportunists could have a higher potential for olfactorial nuisance than late successional macrophytes. To test this hypothesis, odors extracted from equal amounts of nutrient-opportunistic and non-opportunistic species that had been partially degraded under equal conditions were compared in a public survey. Participants graded the smell of opportunistic species, in particular Ceramium tenuicorne, consistently as more intense and less pleasant than the odor of non-opportunistic species. The particularly high potential of Ceramium litter and the relatively lower potential of eelgrass litter for deterrence were confirmed in field experiments. We conclude that the documented compositional shift in macrophyte communities at German Baltic Sea coasts since the onset of eutrophication has caused a shift of beach wrack composition toward species with a higher potential for olfactorial deterrence, which could explain recent concerns of beach managers about beach wrack despite the limited increase of biomass in the study area.
Research on Stability of Gray Value of Excited-State Fluorescent Oil Film Based on Variable Light Vector Angle

In global skin-friction measurement of aircraft, the fluorescent oil film method can characterize the distribution of skin friction well. However, in an actual wind tunnel test, the wing of the aircraft will inevitably produce corresponding vibrations due to the influence of wind, which will change the relative position between fluorescent oil film and UV (ultraviolet) excitation light source (position fixed). This also directly affects gray value imaging of fluorescent oil films. Based on this, a mathematical model is established to judge the stability of the gray value of fluorescent oil film in this vibrational environment; then, the model can be solved to obtain the vibrational range constraint that enables the gray value of fluorescent oil film to be stabilized. In order to simplify the calculation process, the light vector angle is used to describe the constraint, which also makes the results more intuitive. Through experimental analysis and demonstration, the prediction accuracy of this model can reach 95.61%, which has certain practical engineering application significance.
Single contact optical beam induced currents (SCOBIC)-a new failure analysis technique

The Single Contact Optical Beam Induced Currents (SCOBIC) is a new failure analysis technique. By connecting the substrate or power pins of an integrated circuit to the current amplifier, many junctions can be imaged. In contrast, in the optical beam induced current (OBIC) technique, only the junction directly connected to the current amplifier is imaged. The implementation of the SCOBIC approach is discussed and experimental results which validates the SCOBIC approach is presented. Application of the SCOBIC technique for CMOS devices is also discussed.
Elevation of Hyaluronan Synthase by Magnesium Supplementation Mediated through the Activation of GSK3 and CREB in Human Keratinocyte-Derived HaCaT Cells

Skin barrier damage is present in the patients with hereditary disorders of the magnesium channel, but the molecular mechanism has not been fully understood. We found that the expressions of hyaluronan synthase (HAS), HAS2 and HAS3 are influenced by MgCl2 concentration in human keratinocyte-derived HaCaT cells. The exposure of cells to a high concentration (5.8 mM) of MgCl2 induced the elevation of HAS2/3 expression, which was inhibited by mRNA knockdown of nonimprinted in Prader-Willi/Angelman syndrome-like domain containing 4 (NIPAL4). Similarly, the content of hyaluronic acid (HA) was changed according to MgCl2 concentration and the expression of NIPAL4. The MgCl2 supplementation increased the reporter activities of HAS2/3, which were inhibited by NIPAL4 knockdown, indicating that the expressions of HAS2/3 are up-regulated at the transcriptional level. The reporter activities and mRNA levels of HAS2/3, and the production of HA were inhibited by CHIR-99021, a glycogen synthase kinase-3 (GSK3) inhibitor, and naphthol AS-E, a cyclic AMP-response element binding protein (CREB) inhibitor. Furthermore, the mutation in putative CREB-binding sites of promoter region in HAS2/3 genes inhibited the MgCl2 supplementation-induced elevation of promoter activity. Our results indicate that the expressions of HAS2/3 are up-regulated by MgCl2 supplementation in HaCaT cells mediated through the activation of GSK3 and CREB. Magnesium may play a pivotal role in maintaining the skin barrier function and magnesium supplementation may be useful to enhance moisturization and wound repair in the skin.
Features of Summer and Winter Precipitation in the Northern Part of the Black Sea Region: Two Model Case Studies

 vefim38@mail.ru Purpose . The purpose of the study is to reproduce the evolution of clouds and precipitation and to evaluate the summer and winter precipitation features in the Black Sea region and Crimea using the WRF-ARW model. Methods and Results . The results of numerical simulations of the summer and winter atmospheric precipitation in Crimea, and the corresponding comparative characteristics are presented. Based on the example of the convection case in July 2018, shown are the convective activity diurnal dynamics and its spatial features induced by the breeze circulation over Crimea. Moisture balance analysis was performed, and quantitative estimates of the summer precipitation formation mechanism are given. The case study of December 2018 precipitation caused by the cyclone and associated cold front passage highlights the feature of the winter precipitation formation mechanism that is driven by moisture advection. The formation of intense winter and summer precipitation in the Crimean Mountains was also considered. Conclusions. The characteristic feature of summer precipitation is its diurnal periodicity and internal moisture cycle. The impact of breezes leads to the localization of convective clouds and precipitation in the central regions of the peninsula. The winter precipitation-forming cloudiness in Crimea consists predominantly of stratiform clouds; the precipitation patterns are conditioned by the large-scale circulation: the external moisture cycle is of a decisive character in winter. The high-altitude mountain areas are the zones of maximum precipitation in both seasons; they play an important role in the total moisture balance research project 20-45-920017 “Quantitative estimates of precipitation in Southwestern Crimea and Sevastopol based on numerical modeling and radar observations” (financially supported by RFBR and the Sevastopol municipality) and state task No. 0827-2021-0002 “Fundamental studies of the interaction processes in the ocean-atmosphere system conditioning the regional spatial-temporal variability of natural environment
Cerebral Perfusion and Sensory Testing Results Differ in Interstitial Cystitis/Bladder Pain Syndrome Patients with and without Fibromyalgia: A Site-Specific MAPP Network Study

Purpose Fibromyalgia is a common co-morbidity in patients with interstitial cystitis/bladder pain syndrome. Quantitative sensory testing measures and regional cerebral blood flow measures have been noted to differ from healthy controls in both subjects with fibromyalgia and those with interstitial cystitis when studied independently. The present study examined such measures in subjects with the diagnosis of interstitial cystitis both with and without the co-diagnosis of fibromyalgia to determine whether differences in these measures may be associated with co-morbidity. Patients and Methods Female subjects with the diagnosis of interstitial cystitis with (n = 15) and without (n = 19) the co-diagnosis of fibromyalgia as well as healthy control subjects (n = 41) underwent quantitative sensory testing. A subset of these patients (9 with and 9 without fibromyalgia) underwent brain perfusion studies using arterial spin labeled functional magnetic resonance imaging. An analysis was performed of absolute regional cerebral blood flow of regions-of-interest when experiencing a full bladder compared with an empty bladder. Results Subjects with both interstitial cystitis and fibromyalgia were more hypersensitive than those without fibromyalgia as well as healthy controls in most sensory measures except heat. Subjects with interstitial cystitis, but no fibromyalgia, differed from healthy controls only in toleration of the ischemic forearm task. Other co-morbidities were more common in those subjects with both interstitial cystitis and fibromyalgia. Bladder fullness was associated with significantly greater whole brain gray matter blood flow in subjects with interstitial cystitis and fibromyalgia when compared with that of subjects with interstitial cystitis without fibromyalgia. Examination of regional cerebral blood flow in individual regions-of-interest demonstrated statistically significant differences between the subjects with interstitial cystitis with and those without fibromyalgia bilaterally in the thalamus, amygdala and hippocampus, as well as the right prefrontal cortex and greater responsiveness to changes in bladder fullness in the insula. Conclusion Quantitative sensory testing and brain perfusion data support that there are two phenotypes of interstitial cystitis patients, which can be differentiated by a co-diagnosis of fibromyalgia. This may affect responsiveness to treatment and suggest the utility of stratifying interstitial cystitis patients according to their co-morbidities.