Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular typing and sequencing of adenovirus isolated from a conjunctivitis outbreak in a neonatal intensive care unit by PCR

We aimed to evaluate the molecular typing of adenovirus isolated during an epidemic at the Ege University Children's Hospital neonatal intensive care unit (NICU). Materials and methods: During the NICU outbreak management, 40 clinical samples (from 15 newborn infants and 25 health care providers) were sent to a microbiology laboratory in viral transport media. All the samples were processed using a direct fluorescent antibody (DFA) test and a shell vial cell culture followed by adenovirus polymerase chain reaction (PCR) and DNA sequencing. PCR and DNA sequencing for adenovirus hexon gene hypervariable regions 1-6 were done after DNA extraction from clinical specimens. Adenovirus typing was done using BLAST analysis. Results: Ten adenoviruses were isolated from 4 out of 10 infants, 3 out of 5 hospital staff with conjunctivitis, and 3 asymptomatic staff. Ten positive samples were identified as adenovirus type 8 by using BLAST analysis. Conclusion: We isolated adenovirus type 8, one of the most common serotypes causing conjunctivitis, during an adenovirus outbreak in our NICU. The highest positivity was obtained using the PCR method. Although DFA was positive in a limited number of cases, this test was applied rapidly at the beginning of the epidemic and contributed to the prevention of further spread.
Safety assessment of the process PETman, based on Starlinger Decon technology, used to recycle post‐consumer PET into food contact materials

Abstract The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) assessed the safety of the recycling process PETman (EU register number RECYC163) using the Starlinger Decon technology. The input is hot washed and dried poly(ethylene terephthalate) (PET) flakes originating from collected post‐consumer PET containers, mainly bottles, with no more than 5% PET from non‐food consumer applications. They are preheated before being submitted to solid‐state polycondensation (SSP) in a continuous reactor at high temperature under vacuum and gas flow. Having examined the challenge test provided, the Panel concluded that the preheating (step 2) and the decontamination in the continuous SSP reactor (step 3) are the critical steps that determine the decontamination efficiency of the process. The operating parameters to control the performance of these critical steps are temperature, pressure, residence time and gas flow. It was demonstrated that this recycling process is able to ensure that the level of migration of potential unknown contaminants into food is below the conservatively modelled migration of 0.1 μg/kg food. Therefore, the Panel concluded that the recycled PET obtained from this process is not considered of safety concern, when used at up to 100% for the manufacture of materials and articles for contact with all types of foodstuffs for long‐term storage at room temperature, with or without hotfill. Trays made of this recycled PET are not intended to be used in microwave and conventional ovens and such use is not covered by this evaluation.
Chronic Subdural Hematoma: Pitfalls to Avoid for Better Outcome

Introduction: Chronic subdural hematoma is one of the commonest intracranial haemorrhages that affect elderly. Headache and focal neurological deficits are among the commonest presentations. It carries excellent prognosis especially when evacuated probably on right timing. Recurrence rate ranging from 8% - 37% in literatures, we will highlight tricks during peri-operative period to have better outcome and decrease recurrence. Patients and methods: We operated 45 cases of chronic subdural hematoma in Cairo university emergencyhospital, during the period from November 2016 to December 2017; CT brain was done for all cases; clinical data were reported; burr hole evacuation was the standard technique. Suction drain with mild suction pressure was applied and hospital stay was 3 - 4 days after surgery. Patients were followed up to three months. Results: Forty-five patients were operated with 27 cases (60%) having their ages between 5th and 7th decades. Among Twenty-nine males and 16 females, eleven patients (25%) were confused; headache was observed in 12 patients, weakness in 31 cases (69%), dysphasia in two cases and two patients were on renal dialysis. Hypertension was associated as a comorbidity in 18 patients, diabetes mellitus in 11 patients, and smoking in 11 patients. Forty-two patients were discharged home within 3 - 4 days; two cases developed small-sized intra-cerebral hematoma, one case of wound infection, and excellent outcome for all cases on three months follow up visit. Conclusions: Chronic subdural hematoma is one of the commonest intra-cranial haemorrhages in elderly with excellent outcome if managed meticulously in right timing. Good control of co-morbidities, insuring slow clearing of hematoma fluid and staged closure technique are factors linked with better outcome. But larger studies are needed.
Fatigue Related Changes in Electromyographic Coherence between Homologous Vastus Lateralis Muscles

Background. The aim of this study was to examine changes in the coherence between EMG signals of homologous quadriceps (vastus lateralis, VL) muscles during in the beginning and the end of multiple sustained isometric bilateral contraction at maximal effort. Methods. Twelve young healthy males participated in the study. The increase in coherence between EMG signals of homologous VL muscles in alpha band, beta band and gamma band was observed during the performance of sustained maximal bilateral isometric contraction with simultaneous decreases in bilateral force, CAR. EMG frequency and EMG amplitude.Results. The increase in beta band coherence during sustained maximal isometric contraction was negatively correlated with the decrease in bilateral force, CAR, EMG amplitude and EMG frequency indicating the possible role of beta coherence to improve VL muscle activation efficiency during maximal bilateral isometric contraction and overcome the effects of VL muscle fatigue in young healthy males. Keywords: muscle fatigue, EMG coherence, bilateral contraction, common drive.
Optimizing Quality of Care for Septic Patients in Developing

Sepsis is a major cause of morbidity and mortality in intensive care units. It affects millions of people worldwide annually, causing hundreds of thousands deaths and health-care expenditure of at least $16.7 billion per year. This highlights the significance of diagnosing and treating septic patients emergently. Unfortunately, developing countries are struggling with limited resources, lack of educational efforts targeting sepsis, and lack of access to healthcare, hence making it difficult for the healthcare professionals to understand the disease process as well as to recognize and manage sepsis. This review paper will discuss possible strategies for the developing countries to decrease their disproportionately high incidence and mortality of sepsis.
Outcome and follow-up of patients requiring emergency oesophagoscopy for food bolus obstruction over a 5-year period.

INTRODUCTION OFBO is a common occurrence in the emergency setting. Endoscopic removal via rigid or flexible oesophagoscopy is only performed following failure to pass the obstruction after a period of observation and medical management. Despite recommendations from the ESGE, there is currently a lack of high-quality evidence to support the diagnostic work-up of these patients. PURPOSE The purpose of this single centre study was to assess the outcome and follow-up of this population over a 5-year period. We retrospectively collected data regarding all patients undergoing emergency oesophagoscopy between 2012-2017 and recorded their outcomes and subsequent follow-up. R esults: We found that only 33% of patients had diagnostic investigations performed post-operatively and oesophageal pathology was detected in 44% of those investigated. Eosinophilic oesophagitis was the most common diagnosis and OGD was more likely to detect pathology compared to other modalities. C onclusion: Our study suggests that our findings could have been higher had all our patients underwent further investigation. Therefore, we would recommend a diagnostic work-up in all patients following a discussion of the risks associated with an endoscopic examination. We thoroughly support further large-scale collaborative research which can shed better light of evidence on the topic.
Artículo reseña LA LEPTOSPIROSIS CANINA Y SU PROBLEMÁTICA EN MÉXICO

Leptospirosis in dogs is a disease that can have subclinical, acute or chronic presentation. Its diagnosis is difficult due to the multiple clinical aspects and not always jaundice is present. Its symptoms can be sub-clinical; therefore, the serological findings are more frequent than the symptoms of the disease. When the disease shows signs, it can cause death due to hepatic disorders and nephritis. The dogs that survive are carriers of the bacteria through their urine which makes them very risky and an important link in the epidemic chain of leptospirosis in man. The current situation of canine leptospirosis in Mexico is not well known so it is convenient to make a literature review of it.
Using Community-Based Participatory Processes to Bring Health Education Technology to Communities

The purpose of this paper is to describe a community-based participatory process of developing computer tailored messages (a form of technologically advanced health education materials) within a community-based lay health adviser program. This process included: 1) identifying the desired characteristics of the health education materials, 2) prioritizing the content and format of the health education materials, and 3) developing methods for distributing these materials. An overview of the lay health adviser program is presented, followed by a description of how each step was taken, a review of the health education method chosen (computer-tailored messages), and a discussion of the challenges and benefits of using community-based participatory processes to bring appropriate technology to communities.
Technical report: Kidney tumor segmentation using a 2D U-Net followed by a statistical post-processing filter

Each year, there are about 400'000 new cases of kidney cancer worldwide causing around 175'000 deaths. For clinical decision making it is important to understand the morphometry of the tumor, which involves the time-consuming task of delineating tumor and kidney in 3D CT images. Automatic segmentation could be an important tool for clinicians and researchers to also study the correlations between tumor morphometry and clinical outcomes. We present a segmentation method which combines the popular U-Net convolutional neural network architecture with post-processing based on statistical constraints of the available training data. The full implementation, based on PyTorch, and the trained weights can be found on GitHub.
Diagnóstico de Melanoma através de Padrões Binários Locais e Decomposição Espacial

Skin cancer is the cancer form with the highest incidence in the population, and although melanoma is a small fraction of these incidences, it is usually the most severe type of skin cancer. Several types of approaches in the area of automatic detection and diagnosis of this type of disease are being explored as pattern recognition techniques along with machine learning. This work aims to study binary local patterns associated with the spatial decomposition of the lesion region for the automatic detection of melanoma. The study, which compares the performance of the application of three different classifiers to the problem, achieves the best 0.88 result of accuracy and accuracy for the PH2 base demonstrating the methodology’s efficiency to the problem of melanoma detection.
Clinical practice of renal cell carcinoma treatment with nivolumab

Nivolumab alike other immune checkpoint inhibitors has been intensively developed during the last decade. Kidney cancer is among the neoplasm in treatment of which we have accumulated the most experience regarding nivolumab. As improves our understanding of the mechanisms underlying specific cellular immune response, thus improves our understanding of the place the nivolumab holds among other therapeutic options. Recent years brought development of innovative immunotherapy combinations as a method for improving immunotherapy efficacy. This review aims at providing practicing oncologists with key aspects of renal cell carcinoma treatment with nivolumab.
Investigating the Effect of Participation-based Individualized Occupational Therapy on Functional Mobility of Children with Cerebral Palsy in School: A Single-blind Randomized Clinical Trial

Article Info Investigating the Effect of Participation-based Individualized Occupational Therapy on Functional Mobility of Children with Cerebral Palsy in School: A Single-blind Randomized Clinical Trial Atefeh Kalooti1, Mehdi Alizadeh Zarei2*, Malek Amini2 1. MSc. Student, Occupational Therapy Department, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran 2. Rehabilitation Research Center, Occupational Therapy Department, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran Background and Objectives: Cerebral palsy is a non-progressive disorder in the growing brain that disrupts movement and ultimately limits the individual’s performance and participation in a variety of areas, such as everyday life, play, and school activities. Individualized occupational interventions help these children receive appropriate services and supports based on their needs, abilities, and disabilities. Current research aimed at investigating effect of individualized occupational therapy interventions on mobility in children with cerebral palsy in the schools. Methods: This is a Single-blind randomized clinical trial, in which 18 children with cerebral palsy at ages 6-12 were selected using convenience method, and were divided into control and intervention groups using block randomization method. During the research period, the control group like before the research received the conventional occupational therapy interventions for 5 weeks and 12 sessions. The intervention group received occupational interventions based on the individualized appropriate goals. Both groups were assessed by School Function Assessment (SFA). Results: The average age of participants was 10.17 years old. Of these children, 52% used wheelchair . Difference in changes of mobility variables was significant between control and intervention group (P<0.05). Conclusion: The results showed that individual occupational therapy based on participation of children with cerebral palsy in exceptional schools had significant impact on mobility of children in non-academic activities of the school, which requires further studies.
Randomized controlled trial of aquatic exercise for treatment of knee osteoarthritis in elderly people

Aim The aim of this study is to assess the efficacy of aquatic exercise on pain, gait, and balance among elderly patients with knee osteoarthritis. Methods We performed a randomized controlled trial at a university hospital. Overall, 32 men with knee osteoarthritis, aged ≥ 60 years, were included. Pain, balance, and gait were evaluated before and 2 months after interventions. The group control used acetaminophen and followed lifestyle recommendations. The intervention group performed the aquatic exercise three sessions per week for 8 weeks. Results At the end of the study, mean pain scores were significantly different between the groups (p = 0.010). Within-group analyses showed that group intervention experienced significant pain relief (p = 0.019), whereas group control did not show the significant change (p = 0.493). There was significant improvement in favor of aquatic exercise with regard to static (p = 0.001) and dynamic (p = 0.001) balance, step length (p = 0.038), stride length (p < 0.001), and cadence (p < 0.001). However, we did not find a significant difference in step time and width between the two groups. Conclusions Aquatic exercise would be beneficial in decreasing subjective pain of osteoarthritis. There are some recognizable improvements in patients’ gait and balance as well.
The Room as Metaphor: Next-of-Kin’s Experiences in End-of-Life Care

The “room” in end-of-life is a phenomenon that needs deeper understanding as it is a dimension that shows how health and suffering are shaped. Research on the concept of room was chosen as theoretical foundation in this study in order to reach a profound understanding of the next-of-kin’s “room” in end-of-life care. Lassenius’s hermeneutic interpretation in metaphorical language was used as an deductive-inductive approach to the empirical data. The data material comprised 33 interviews with next-of-kin about their experiences of end-of-life care when being close to a relative dying from a cancer disease. The analysis of the data formed four cases: the Standby, the Asylum, the Wall, and the Place. These cases lend their voices to the experiences of the next-of-kin in the study. The findings of this study explain and may well assist nurses to understand the experiences of being next-of-kin in end-of-life care as forming a room of rest from the suffering, a room of controlling the suffering, a room of hiding from the suffering, and a room of belonging.
Is it time to relax nephrogenic systemic fibrosis guidelines and safely offer magnetic resonance imaging to more patients?

Nephrogenic systemic fibrosis (NSF) is a potentially fatal fibrosing disorder that involves the skin and other internal organs. It is almost always associated with an advanced degree of chronic kidney disease (CKD) or acute kidney injury (AKI). Advances in medical knowledge underpinned some understanding of the pathophysiology and aetiology of this condition which then led to the emergence of strict guidelines for the use of gadolinium (Gd) enhanced MRI scans (Gd-MRI).
Biomarkers in Relation to the Effects of Ticagrelor in Comparison With Clopidogrel in Non–ST-Elevation Acute Coronary Syndrome Patients Managed With or Without In-Hospital Revascularization: A Substudy From the Prospective Randomized Platelet Inhibition and Patient Outcomes (PLATO) Trial

Background— Risk stratification and the use of specific biomarkers have been proposed for tailoring treatment in patients with non–ST-elevation acute coronary syndrome (NSTE-ACS). We investigated the prognostic importance of high-sensitivity troponin T (hs-TnT), N-terminal pro-brain natriuretic peptide (NT-proBNP), and growth differentiation factor-15 (GDF-15) in relation to randomized treatment (ticagrelor versus clopidogrel) and management strategy (with or without revascularization) in the NSTE-ACS subgroup of the Platelet Inhibition and Patient Outcomes (PLATO) trial. Methods and Results— Of 18 624 patients in the PLATO trial, 9946 had an entry diagnosis of NSTE-ACS and baseline blood samples available. During index hospitalization, 5357 were revascularized, and 4589 were managed without revascularization. Hs-TnT, NT-proBNP, and GDF-15 were determined and assessed according to predefined cutoff levels. Median follow-up was 9.1 months. Increasing levels of hs-TnT were associated with increasing risk of cardiovascular death, myocardial infarction, and stroke in medically managed patients (P<0.001), but not in those managed invasively. NT-proBNP and GDF-15 levels were associated with the same events independent of management strategy. Ticagrelor versus clopidogrel reduced the rate of cardiovascular death, myocardial infarction, and stroke in patients with NSTE-ACS and hs-TnT ≥14.0 ng/L in both invasively and noninvasively managed patients; in patients with hs-TnT <14.0 ng/L, there was no difference between ticagrelor and clopidogrel in the noninvasive group Conclusions— Hs-TnT, NT-proBNP, and GDF-15 are predictors of cardiovascular death, myocardial infarction, and stroke in patients with NSTE-ACS managed noninvasively, and NT-proBNP and GDF-15 also in those managed invasively. Elevated hs-TnT predicts substantial benefit of ticagrelor over clopidogrel both in invasively and noninvasively managed patients, but no apparent benefit was seen at normal hs-TnT. Clinical Trial Registration— URL:http://www.clinicaltrials. gov. Unique identifier: NCT00391872.
Myocardium in a dish : the influence of cellular and extracellular perturbations on cardiomyocyte contractility

• A submitted manuscript is the author's version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers.
The Student's Satisfaction Influential Factors at Cihan University

Universities are increasingly operating in Erbil. There is fierce competition among these universities to attract students. Students' satisfaction has become increasingly important for university to survive. The purpose of this study is to find the perception status of students' satisfaction and the factors that affect it at Cihan University in Erbil. The relationship between the dependent variable of this study which is customer satisfaction and the independent variables which are service quality physical environment; and study fees, is investigated in this study. The study uses adopted questionnaire to collect the data from respondents. Respondents are students at Cihan University. Three departments are selected to be the place for data collection. The findings of the research shows that the perception status of students' satisfaction is 3.39 with moderate agreement of almost all the items of statement. The overall mean score value of service quality by the respondents is found to be 3.53 with agreement of all the items of statement , of physical environment is found to be 3.22 with moderate agreement on all items of statement, and of study fees by respondents is 3.08 with moderate agreement on all items of statement. The hypotheses testing shows that there is positive and significant relationship between customer satisfaction and other variable such as service quality and physical environment with correlation of 0.312, and 0.290 respectively. The relationship between study fees and customer satisfaction is found to be negative and insignificant with correlation of -0.093.
The Effects of a Multi-Flavonoid Supplement on Cardiac Autonomic Regulation

Antioxidant supplementation has been shown to stimulate positive effects on cardiovascular health including a reduction in blood pressure by alleviating arterial stiffness, but little is known of the benefits of antioxidants on the autonomic nervous system. This study aims to look at the effects of a multi-flavanoid supplement combined with an acute bout of exercise and its effects on heart rate variability and autonomic function in pre-hypertensive, middle-aged individuals. 20 pre-hypertensive middle-aged individuals were randomly assigned to the placebo or treatment group. Subjects reported to the lab for baseline measurements. Beat-to-beat BP was measured on each subjects left arm and heart rate (HR) was monitored using a three lead electrocardiogram to attain cardiac autonomic modulation variables. Subjects were lying on a motorized tilt table, supine for 5 minutes, tilted head-up for 5 minutes and were lying supine again for 5 minutes, while measurements were being taken. Subjects supplemented for two weeks and returned for post measurements. The multi-flavonoid antioxidant supplementation showed favorable effects on the ANS by lowering the sympathetic outflow, and there was no additive effect of exercise and supplementation following the acute bout of aerobic exercise.