Miracle-dz/UniFAR-FTUs huggingface dataset:
Proper Motions of Dwarf Spheroidal Galaxies from Hubble Space Telescope Imaging. II. Measurement for Carina

This article presents and discusses a measurement of the proper motion for the Carina dwarf spheroidal galaxy (dSph) from images in two distinct fields in the direction of Carina taken with the Hubble Space Telescope, at three epochs. Each field contains a confirmed quasi-stellar object that is the reference point for measuring the proper motion of the dSph. The consecutive epochs are 1–2 yr apart. The components of the measured proper motion for Carina, expressed in the equatorial coordinate system, are μα = 22 ± 9 mas century-1 and μδ = 15 ± 9 mas century-1. The quoted proper motion is a weighted mean of two independent measurements and has not been corrected for the motions of the Sun and of the local standard of rest. Given the proper motion and its uncertainty, integrating the family of possible orbits of Carina in a realistic gravitational potential for the Milky Way indicates that Carina is bound gravitationally to the Milky Way and is close to apogalacticon. The best estimate of, and the 95% confidence interval for, the apogalacticon of the orbit is 102 kpc and (102, 113) kpc, for the perigalacticon is 20 kpc and (3.0, 63) kpc, and for the orbital period is 1.4 Gyr and (1.3, 2.0) Gyr. Carina does not seem to be on a polar orbit. The best estimate of the inclination of the orbit with respect to the Galactic plane is 39°, but the 95% confidence interval is so wide, (23°, 102°), that it includes a polar orbit. We are unable to confirm or to rule out the membership of Carina in a "stream" of galaxies in the Galactic halo because the difference between the observed and predicted directions of the proper motion is 1.6 times the uncertainty of the difference. Carina must contain dark matter to have survived the tidal interaction with the Milky Way until the present. The triggering of star formation by perigalacticon passages and crossings of the Galactic disk do not explain the history of star formation in Carina.
TELLING THE AMERICAN STORY A Structural and Cultural Analysis of Conversational Storytelling

Burke and the Fall of Language The French Revolution as Linguistic Event STEVEN BLAKEMORE A highly original portrayal of the battles over meaning and language between Edmund Burke and late 18th-century revolutionaries. It argues that Burke saw the French Revolution as an astonishing linguistic event, consequently developing a theory of language to explain the conflict and the fall of the traditional 18th-century world. The book shows that revolutionaries and counterrevolutionaries were engaged in a war over language that was an extension of their ideological battle. $15.00
A CROSS-SECTIONAL RESEARCH ON THE WEAK ASSOCIATION OF SERENE THREONINE KINASE – 39 GENE TO ESSENTIAL HYPERTENSION (EHTN) WITH RESPECT TO INCREASING AGE FACTOR, BMI AND DIABETES IN THE ABSENCE OF EXERCISE AND PHYSICAL ACTIVITY

Objective: This research was aimed to study the (Serine Threonine Kinase-39) A-G prevalence polymorphism in the population that is settled in the rural areas. Methods: Nature of the research was cross-sectional, random which was completed in the time span of 2015 – 2017 on 528 participants. We excluded secondary hypertension cases from the record of this research. Controls and cases were respectively Normotensives and Hypertensives. We performed genotyping by tetra-primer amplification refraction mutation system by using a chain reaction of the polymerase and analysis of the data was carried out on SPSS. Results: Serine Threonine Kinase – 39 has an association with the critical hypertension which was measured as (3.07) (CI 95%, range 2.10 – 4.49) and in units it was described as (mmHg) / G allele (P-Value = 0.001). An elevated systolic BP (Above 140 mmHg) which reflected (0.76) (CI, 95%, 0.47 – 1.23) (P – value= 0.235) & raised diastolic Blood Pressure (> 90 mmHg) reflected as 0.93 (95% CI, 0.61 – 1.44) units/mmHg / G allele (P-value = 0.735). Risk allele G frequency was under (33.3%) in comparison to the allele – A (66.7%), (P-Value = 0.0001). Non-significant genetic factors size was observed as (0.062, P-value = 0.153), GG homozygotes (0.013, P-value = 0.772) and for the AG heterozygotes. Risk factors effective size was observed as (age above 50 years, diabetes and BMI above 23) had an association with the incidence of essential hypertension (0.747, P-value = 0.000). Effect was increased by (12.04 fold) in GG genotype and another three folds with the influence of the factors of risk which was required for the single allele-G in AG heterozygotes cases. Conclusion: Risk of the essential hypertension as observed by polymorphism as observed in our research was not same as it was reported previously by a European author. It was suggested that variant G allele has a weak association when the environmental risk factors are absent.
Effect of Early Mobilizat ion on Physical Funct ion in Pat ients after Cardiac Surgery: A Systemat ic Review and Meta-Analysis

The objective effects of early mobilization on physical function in patients after cardiac surgery remain unknown. The purpose of the present study was to clarify the effects of early mobilization on physical function in patients after cardiac surgery through meta-analysis. Four electronic databases were searched on 2 August 2019. We used search keywords related to “early mobilization”, “cardiac surgery”, and “randomized controlled trials”. All randomized controlled trials conducting early mobilization after cardiac surgery were included. We defined early mobilization as the application of physical activity within the first five postoperative days. Citations and data extraction were independently screened in duplicate by two authors. The meta-analysis was conducted using random-effects modeling with EZR software. The primary outcome was the distance walked during the six-minute walking test at hospital discharge. Six randomized controlled trials comprising 391 patients were included following screening of 591 studies. All studies included coronary artery bypass grafting as the cardiac surgery conducted. Early mobilization started on postoperative days 1–2 and was conducting twice daily. Early mobilization showed a trend of being combined with respiratory exercise or psychoeducation. The meta-analysis showed that the distance walked during the 6-min walking test improved by 54 m (95% confidence interval, 31.1–76.9; I2 = 52%) at hospital discharge. The present study suggested that early mobilization after cardiac surgery may improve physical function at discharge.
Analysis of dc-Link Voltage Switching Ripple in Three-Phase PWM Inverters

The three-phase voltage source inverter (VSI) is de facto standard in power conversion systems. To realize high power density systems, one of the items to be correctly addressed is the design and selection of the dc-link capacitor in relation to the voltage switching ripple. In this paper, effective formulas for designing the dc-link capacitor as a function of the switching voltage ripple amplitude are obtained, considering the operating conditions such as the modulation index and the output current amplitude. The calculations are obtained considering the requirements and restrictions referring to the high (switching)-frequency dc-link voltage ripple component. Analyses have been performed considering the dc source impedance (non-ideal dc voltage source at the switching frequency) and a balanced load. Analytical expressions are derived for the dc-link voltage switching ripple amplitude and its maximum value over the fundamental period. Different values of modulation index and output phase angle have been considered and different diagrams are presented. Analytical results were validated both by simulations and comprehensive experimental tests.
Tourism Carbon Kuznets-Curve Hypothesis

Since the introduction of the carbon Kuznets-curve hypothesis in the mid-1990s, the inverted U–shaped relationship between economic development and carbon emissions has remained a subject of debate in the social sciences. We engage tourism research in this debate, in a fourfold manner. First, we offer a systematic literature review concerning the role of tourism in the carbon Kuznets-curve hypothesis using a protocol-based reporting process. Second, we present the level of consensus with the carbon Kuznets-curve hypothesis and the conceptual gaps in the identified literature (n1⁄4 22). Third, we introduce an emerging concept, offering a novel tourism corporate/performance orientation to the carbon Kuznets-curve hypothesis. Fourth, we provide evidence of empirical validity using different econometric techniques from an international tourism corporation (n1⁄4 86) data set (2005–2018). The inverted U–shaped relationship between measures of economic and carbon performance among tourism corporations is a robust result under many different specifications.
GRANULOPOIETIC PROFILE AND EXAGGERATED ACUTE NEUTROPHILIC INFLAMMATION IN MICE WITH TARGETED DEFICIENCY IN THE SIALYLTRANSFERASE , ST 6 GAL I

word count: 199 Blood First Edition Paper, prepublished online July 18, 2006; DOI 10.1182/blood-2006-04-014779 Copyright © 2006 American Society of Hematology For personal use only. on August 21, 2017. by guest www.bloodjournal. org From
H-IomK CONCENTRATIONS OF SOLUTIONS IN CATHODE AND ANODE CHAMBERS IN THE ELEC-

The separation of ions from colloids by the process of electrodialysis is a procedure that is being used with many types of materials. It has been especially favored since the introduction of the three compartment cell described by MATTSON (1). MOORE, REEVES, and HIXON (2) appear to have been the first to employ this electrolytic method of dialyzing fruit tissue. They used the peels from Jonathan apples and found that samples from fruits affected with "Jonathan spot" reacted differently than those from normal fruits.
Granzyme B-Induced Loss of Mitochondrial Inner Membrane Potential (ΔΨm) and Cytochrome c Release Are Caspase Independent

CTLs kill targets by inducing them to die through apoptosis. A number of morphological and biochemical events are now recognized as characteristic features of the apoptotic program. Among these, the disruption of the inner mitochondrial transmembrane potential (ΔΨm) and the release of cytochrome c into the cytoplasm appear to be early events in many systems, leading to the activation of caspase-3 and, subsequently, nuclear apoptosis. We show here that, in Jurkat targets treated in vitro with purified granzyme B and perforin or granzyme B and adenovirus, ΔΨm collapse, reactive oxygen species production, and cytochrome c release from mitochondria were observed. Loss of ΔΨm was also detected in an in vivo system where green fluorescent protein-expressing targets were attacked by a cytotoxic T cell line that kills predominantly through the granzyme pathway. DNA fragmentation, phosphatidylserine externalization, and reactive oxygen species production were inhibited in the presence of the caspase inhibitors benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone (zVAD-fmk) and benzyloxycarbonyl-Asp-Glu-Val-Asp-fluoromethyl ketone (zDEVD-fmk) in our in vitro system. Importantly, in either the in vitro or in vivo systems, these inhibitors at concentrations up to 100 μM did not prevent ΔΨm collapse. In addition, cytochrome c release was observed in the in vitro system in the absence or presence of zVAD-fmk. Thus the granzyme B-dependent killing pathway in Jurkat targets involves mitochondrial alterations that occur independently of caspases.
The prognosis and changes of regional brain gray matter volume in MDD with gastrointestinal symptoms

Objective: It is common that major depressive disorder (MDD) is accompanied by gastrointestinal (GI) symptoms. However, few studies have focused on the clinical characteristics and its possible mechanism, while brain gray matter (GM) structure is important in the pathogenesis of GI symptoms. In this study, we aimed to investigate the basic clinical characteristics and regional GM volume changes in MDD accompanied by GI symptoms. Method: Patients with MDD (n=49) and age, gender, and educational level-matched healthy controls (n=30) were recruited. Patients with MDD were divided into two groups based on the GI status: MDD with (n=27) and without (n=22) GI symptoms. The 24-item Hamilton Depression Rating Scale (HAMD) was administered. T1-weighted anatomical images were obtained and analyzed. Correlation analysis was used to identify the possible associations between changed regional GM volume and GI symptoms and depressive symptoms. Results: The HAMD reductive ratio for 2 weeks of treatment in the GI symptoms group was signi ﬁ cantly higher than the non-GI symptoms group ( P <0.05). The regional GM volume showed signi ﬁ cant differences among the three groups (Gaussian Random Field [GRF] correction, voxel- P <0.01, cluster- P <0.05). Compared with non-GI symptoms group, GI symptoms group exhibited signi ﬁ cantly increased GM volume in the left hippocampus, left parahippocampal gyrus, right parahippocampal gyrus; and decreased GM volume in the voxel- P <0.01, cluster- P <0.05). These altered brain areas were correlated with the GI symptoms, not depressive symptoms. Conclusion: The changed regional brain GM volume in GI-MDD group may be the pathogenesis for the GI symptoms. In addition, the GI symptoms may predict the prognosis of MDD.
SyndromeAutoantigen Cleavage in Murine Sjögren's Exocrinopathy Is Dependent on Pathogenic Prevention and Induction of Autoimmune

The in vivo role of autoantigen cleavage during apoptosis in autoimmune diseases remains unclear. Previously, we found a cleavage product of 120-kDa (cid:1) -fodrin as an important autoantigen in the pathogenesis of primary Sjo¨gren’s syndrome (SS). In the murine primary SS model, tissue-inﬁltrating CD4 (cid:2) T cells puriﬁed from the salivary glands bear a large proportion of Fas ligand, and the salivary gland duct cells constitutively possess Fas. Inﬁltrating CD4 (cid:2) T cells, but not CD8 (cid:2) T cells, identiﬁed signiﬁcant 51 Cr release against mouse salivary gland cells. In vitro studies demonstrated that apoptotic mouse salivary gland cells result in a speciﬁc (cid:1) -fodrin cleavage into 120 kDa and that preincubation with caspase inhibitor peptides blocked (cid:1) -fodrin cleavage. In vivo treatment with caspase inhibitors N -benzyloxycarbonyl-Val-Ala-Asp ﬂuoromethyl ketone and N -acetyl-Asp-Glu-Val-Asp-al-CHO into the murine model results in dramatic inhibitory effects on the development of autoimmune lesions and in restoration of sicca syndrome. Furthermore, we found that immunization with recombinant (cid:1) -fodrin protein identical with an autoantigen into normal recipients induced autoimmune lesions similar to SS. These data indicate that prevention and induction of autoimmune exocrinopathy is dependent on autoantigen cleavage via caspase cascade and that caspase inhibitors might provide a new therapeutic option directed at reducing tissue damage in the murine model for SS.
DDDT_A_337925 4939..4959

Department of Pharmacy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, 110042, Liaoning Province, People’s Republic of China Abstract: Bone tumors are tumors that occur in the bone or its accessory tissues, including primary tumors and metastatic tumors. The main mechanism of bisphosphonate is to inhibit the resorption of destructive bone, inhibit the activity of osteoclasts and reduce the concentration of blood calcium. Therefore, bisphosphonates can be used for malignant hypercalcaemia, pain caused by osteolytic bone metastasis, prevention of osteolytic bone metastasis, multiple myeloma osteopathy, improving radiosensitivity and so on. However, the traditional administration of bisphosphonates can cause a series of adverse reactions. To overcome this disadvantage, it is necessary to develop novel methods to improve the delivery of bisphosphonates. In this paper, the latest research progress of new and improved bisphosphonate drug delivery methods in the treatment of bone tumors is reviewed. At present, the main design idea is to connect bisphosphonate nanoparticles, liposomes, microspheres, microcapsules, couplings, prodrugs and bone tissue engineering to targeted anti-tumors systems, and positive progress has been made in in vitro and animal experiments. However, its safety and effectiveness in human body still need to be verified by more studies.
Conceptual Injector Design for an Electron-Ion-Collider Front-End

The 2015 Long Range Plan for Nuclear Science recommended a high-energy high-luminosity polarized Electron Ion Collider (EIC) as the highest priority for new facility construction [1]. A hadron linac with a final energy of 40MeV/u for heavy ions and up to 130 MeV for protons with an upgrade path to higher energies is required as the first step of the hadron accelerator chain [2]. For energies above ∼5 MeV/u, a linac utilizing superconducting cavities likely has a lower cost than that provided by room temperature (rt) structures whereas rt structures are preferred for energies below ∼5 MeV/u The front-end consists of two separate injectors based on efficient H-mode cavities, one optimized for heavy ions (Pb30+) and the other optimized for protons and deuterons.
Bamboo in a Sandpile Methodological Considerations for Leveraging Data to Enhance Infrastructural Resilience

—The onset of the Big Data phenomenon presents significant technological challenges in managing massive amounts of information, yet it also presents tremendous opportunities for enhancing societal resilience and directly serving the public good. The Internet of Everything, which is driving such massive connectivity and growth in data generation is a highly complex system, continuously giving rise to new communication capabilities, yet also becoming increasingly vulnerable to destabilizing forces and malicious threats. Creating systems that are truly intelligent and capable of balancing these interrelated dynamics in the management of data demands a deliberate approach that is scalable, adaptive, and extensible. In this paper, we discuss three primary considerations for conducting Collaborative Big Data Analytics, including data acquisition, layered analytics, and visualization in order to grow resilient cyber-physical infrastructures that are capable of withstanding significant destabilization. With regard to data acquisition, we present the basic characteristics of so-called Big Data, namely the Six Vs of data variety, volume, velocity, veracity, volatility, and value. In addition, we outline the development of analytical tools and techniques for processing data, as well as methods for effectively visualizing the products of a layered analytic approach. In order to illustrate the utility of such an approach, we summarize findings from our participation in Orange Telecom’s Data for Development Challenges in the Republic of Côte d'Ivoire and Senegal, as well as introduce initial findings from our ongoing study of infrastructural resilience in archipelagos. We conclude that while Collaborative Big Data Analytics hold great promise, forums for the open development and validation of methodologies for its conduct are needed to generate more and better uses of the Big Data that have come to dominate our world
Unstructured Road Segmentation using Hypercolumn based Random Forests of Local experts

Monocular vision based road detection methods are mostly based on machine learning methods, relying on classification and feature extraction accuracy, and suffer from appearance, illumination and weather changes. Traditional methods introduce the predictions into conditional random fields or markov random fields models to improve the intermediate predictions based on structure. These methods are optimization based and therefore resource heavy and slow, making it unsuitable for real time applications. We propose a method to detect and segment roads with a random forest classifier of local experts with superpixel based machine-learned features. The random forest takes in machine learnt descriptors from a pre-trained convolutional neural network - VGG-16. The features are also pooled into their respective superpixels, allowing for local structure to be continuous. We compare our algorithm against Nueral Network based methods and Traditional approaches (based on Hand-crafted features), on both Structured Road (CamVid and Kitti) and Unstructured Road Datasets. Finally, we introduce a Road Scene Dataset with 1000 annotated images, and verify that our algorithm works well in non-urban and rural road scenarios.
SARS-CoV-2 infection in cats and dogs in infectedmink farms

Anna E. van Aart1 Francisca C. Velkers2 Egil A.J. Fischer2 ElsM. Broens3 Herman Egberink4 Shan Zhao4 Marc Engelsma5 RenateW. Hakze-van der Honing5 FrankHarders5 MyrnaM.T. de Rooij1 Carien Radstake6 Paola A.Meijer2 Bas B. OudeMunnink7 Jan de Rond8 Reina S. Sikkema7 ArcoN. van der Spek9 Marcel Spierenburg9 Wendy J.Wolters2 Robert-JanMolenaar8 Marion P.G. Koopmans7 WimH.M. van der Poel5 Arjan Stegeman2 Lidwien A.M. Smit1
METHOD DEVELOPMENT AND VALIDATION OF RP-HPLC FOR THE DETERMINATION OF LAMIVUDINE FROM DRUG LOADED NANOPARTICLE PHARMACEUTICAL FORMULATION

METHOD DEVELOPMENT AND VALIDATION OF RP-HPLC FOR THE DETERMINATION OF LAMIVUDINE FROM DRUG LOADED NANOPARTICLE PHARMACEUTICAL FORMULATION P. Pravalika Reddy, Dr. B. Madhava Reddy, Dr. D. Jaya Prakash, Dr. K. Latha Malla Reddy Pharmacy College, Maisammaguda, Secunderabad, Telangana, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Telangana. , Neil Gogte Institute of Technology, Peerzadiguda, Uppal. Article Received: March 2019 Accepted: April 2019 Published: May 2019
Explicit IMF <fi>B<sub>y</sub></fi> Dependence in Highâ•’Latitude Geomagnetic Activity

The interaction of the solar wind with the Earth’s magnetic field produces geomagnetic activity, which is critically dependent on the orientation of the interplanetary magnetic field (IMF). Most solar wind coupling functions quantify this dependence on the IMF orientation with the so-called IMF clock angle in a way, which is symmetric with respect to the sign of the By component. However, recent studies have suggested that the sign of By is an additional, independent driver of high-latitude geomagnetic activity, leading to higher (weaker) geomagnetic activity in Northern Hemisphere (NH) winter for By > 0 (By < 0). In this paper we quantify the size of this explicit By effect with respect to the solar wind coupling function, both for northern and southern high-latitude geomagnetic activity. We show that high-latitude geomagnetic activity is significantly (by about 40%–50%) suppressed for By < 0 in NH winter and for By > 0 in Southern Hemisphere winter. When averaged over all months, high-latitude geomagnetic activity in NH is about 12% weaker for By < 0 than for By > 0. The By effect affects the westward electrojet strongly, but hardly at all the eastward electrojet. We also show that the suppression of the westward electrojet in NH during By < 0 maximizes when the Earth’s dipole axis points toward the night sector, that is, when the auroral region is maximally in darkness.