Miracle-dz/UniFAR-FTUs huggingface dataset:
A feature generation framework for Google trace analysis

Analysis of Cloud workloads using data mining technology is critical for improving resource management. Unfortunately there is a lack of systematic approach to support the feature generation in comprehensive workload analysis. In this paper we propose a function based generalized feature generation method for the analysis of a one-month trace of a Google data center over 40 million task events across about 12,000 machines. The feature set is generated by a set of constructor functions that can keep interpretability and be partly automatically generated. These can be calculation function that can be performed automatically, such as aggregate, synthesis, and statistical operators, or reduction operators that rely on prior information. The proposed method was experimentally evaluated in the host load prediction based on Naive Bayes algorithm. Experiment results show the well performance of our method.
Altered immunoglobulin isotype profile and anti‐immature worm surface immunoglobulins in mice harboring a praziquantel‐resistant Schistosoma mansoni isolate

After placement in mice of PZQ‐sensitive and ‐insensitive S. mansoni isolates obtained from villagers responding and not responding to PZQ, parasitological criteria reflecting their biological development and also the host anti‐immature worm immunoglobulin isotypes were examined 8 and 10 weeks post infection. Hepatic granuloma diameter, hepatic histopathological changes and immunolocalization of IgG and IgM on the surface of PZQ‐sensitive and ‐resistant worms were also examined 10 weeks post infection. Data showed that parasitological criteria were not significantly different between mice infected with the PZQ‐sensitive and ‐insensitive S. mansoni isolates. As regards serum immunoglobulins, in mice infected with the PZQ‐insensitive S. mansoni isolate, IgG and IgG1 were significantly (p<0.05) lower 8 and 10 weeks post infection, respectively (1.41±0.07 & 1.08±0.10 and 1.35±0.06 & 1.09±0.07) than in mice infected with the PZQ‐sensitive S. mansoni isolate (1.73±0.15 & 1.38±0.10 and 1.73±0.17 & 1.54+0.21) after the same observation periods. IgM level was nearly the same while IgE was lower than that recorded in mice infected with the PZQ‐sensitive S. mansoni isolate. IgG immunofluorescence was also lower (60%±6.78) on the surface of resistant worms than that of sensitive worms (66.6%±5.27); meanwhile, hepatic granuloma diameter was significantly larger (296.5±3.0 vs 283.6±4.0) in mice infected with the PZQ‐insensitive S. mansoni isolate with higher percentage of intact eggs. Differences in the immunogenic make up of PZQ‐sensitive and ‐insensitive S. mansoni isolates qualitatively and/or quantitatively favoring a certain Th cell subpopulation response could be the underlying reason for such differences recorded in the host immunoglobulin isotype response and also the egg‐induced hepatic histopathological changes.
Nkx2.2:Cre knock‐in mouse line: A novel tool for pancreas‐ and CNS‐specific gene deletion

Nkx2.2 is a homeodomain‐containing transcriptional regulator necessary for the appropriate differentiation of ventral neuronal populations in the spinal cord and hindbrain, and endocrine cell populations in the pancreas and intestine. In each tissue, Nkx2.2 inactivation leads to reciprocal cell fate alterations. To confirm the cell fate changes are due to respecification of Nkx2.2‐expressing progenitors and to provide a novel tool for lineage tracing in the pancreas and CNS, we generated an Nkx2.2:Cre mouse line by knocking in a Cre‐EGFP cassette into the Nkx2.2 genomic locus and inactivating endogenous Nkx2.2. The R26R‐CAG‐LSL‐tdTomato reporter was used to monitor the specificity and efficiency of Nkx2.2:Cre activity; the tomato reporter faithfully recapitulated endogenous Nkx2.2 expression and could be detected as early as embryonic day (e) 9.25 in the developing CNS and was initiated shortly thereafter at e9.5 in the pancreas. Lineage analyses in the CNS confirmed the cell populations thought to be derived from Nkx2.2‐expressing progenitor domains. Furthermore, lineage studies verified Nkx2.2 expression in the earliest pancreatic progenitors that give rise to all cell types of the pancreas; however they also revealed more robust Cre activity in the dorsal versus ventral pancreas. Thus, the Nkx2.2:Cre line provides a novel tool for gene manipulations in the CNS and pancreas. genesis 51:844–851. © 2013 Wiley Periodicals, Inc.
Reengineering a National Resource Discovery Service: MODS Down Under

Australian libraries have shared resources and records for over two decades through Kinetica, a service provided by the National Library of Australia. While this service has broadly met the needs of its users, comprising over 1000 Australian libraries, the Library is reengineering the service, using MODS (Metadata Object Description Schema) to improve coverage of online publications and records from specialist collections. This article describes the use of MODS to transform records for digital resources into MARC records for resource discovery.
Synergistic Capsicum‐tea mixtures with anticancer activity

We have demonstrated a synergy between a decaffeinated green tea concentrate and a vanilloid‐containing Capsicum preparation obtained commercially. At a ratio of 25 parts green tea concentrate to 1 part Capsicum preparation, the resultant product exhibited efficacy in the killing of cancer cells in culture 100‐times that of green tea on a weight basis. These studies were guided by assays of the putative catechin‐vanilloid target protein tNOX, a cell surface growth‐related enzymatic activity specific to cancer. The activity of the protein target was inhibited by the tea catechins and the Capsicum vanilloids. As with growth, the tea and Capsicum preparations evaluated were synergistic in their inhibition of the target enzymatic activity.
Sonography in prenatal diagnosis of congenital adrenal hyperplasia

Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder with an incidence of 1/15 000. More than 90% of CAH cases result from mutations of CYP21, leading to 21‐hydroxylase deficiency. In its classical form, CAH is severe and consists of the virilizing (increase of androgens) and salt‐wasting (lack of aldosterone) phenotype. When a proband exists, early prenatal diagnosis for CAH can be performed by direct molecular analysis in the first trimester. We describe herein two cases suggesting that the prenatal diagnosis of CAH can be initiated by the sonographic appearance of the adrenal gland at the second‐trimester scan in the absence of a family history. Copyright © 2004 John Wiley & Sons, Ltd.
Testbench Design for Mixed Signal SoC Based on Task Flow

To reduce the testing cost of IP cores in SoC systems, a novel design method of the testbench based on task flow is proposed in this paper, which tries to improve the test coverage, differing from reducing test time and resources. The method is designed for applying to a mixed-signal SoC system. With functional model analysis, as an example, the system DFG model for a mixed signal SoC is derived. Following the design specification and DFG, three tasks and their constraints to the system test are extracted. Finally the testbench and test program are designed. The simulation results with Modelsim show that the functions coverage of the testbench based on task flow can reach 100% for IP modules.
Analysis of abnormally enhanced ion line power spectra structure in ionospheric heating experiments

Polar autumn ionospheric heating experiments were carried out by China in September 2010 at Tromso, Norway. In the experiments, some different structures of ion lines spectra caused by heating are observed. With the experimental data on September 5, 6, 13, 15, four abnormal spectra structures of ion lines are given, and some explanation is presented. Our work will provide some suggestion for the inversion of ionospheric parameters with abnormal ion lines spectra in heating experiments.
Electrode layout of wristband EMG measuring device for hand gesture recognition

In this study, we discuss a layout of electrodes on a wrist for EMG measurements to recognize hand gestures. Experimental results show that the proposed layout uses only half of the electrodes, but suffers only about 3% drop in recognition rate compared with the conventional layout. Furthermore, we developed a television operating system based on hand gestures, using a wristband-type EMG device with the proposed electrode layout.
Calmodulin in Complex with Proteins and Small Molecule Ligands: Operating with the Element of Surprise.Implications for Structure-Based Drug Design

Calmodulin plays a role in several life processes, its flexibility allows binding of a number of different ligands from small molecules to amphiphilic peptide helices and proteins. Through the diversity of its functions, it is quite difficult to find new drugs, which bind to calmodulin as a target. We present available structural information on the protein, obtained by X-ray diffraction, nuclear magnetic resonance spectroscopy and molecular modeling and try to derive some conclusions on structure-activity relationships.
Polarization diversity analysis in rural scenarios using 3D Method-Of-Images model

Spatial-MIMO systems have been studied thoroughly during the last decade. Polarization characteristics of wireless signals, on the other hand, were not treated yet in a similar manner. Polarization can be used as another dimension for achieving diversity gain in the full three dimensional reality. In the current analysis, the Polarized-MIMO potential in a Rural Area setting is studied. The analysis introduces P-MIMO 3D channel model based on the, so-called, Method-Of-Images. It is shown that relative to degenerate polarization-dimension techniques (such as SISO and SIMO) there is a significant capacity improvement when using several polarizations concurrently. The potential of P-MIMO realization in future broadband wireless systems is clearly demonstrated.
Ransomware prevention technique using key backup

In this paper, a key backup technique for the recovery of files encrypted by ransomware is proposed. Ransomware interferes with the victim's system through abnormal behavior such as locking of the victim's system or encryption of the system or files. Ransomware writers demand money from the victims as a condition for the recovery of the encrypted files and systems that have been seized; systems infected by ransomware cannot be repaired without a decryption key, making the employment of detection and recovery methods urgent. This paper proposes a prevention technique for backing up encryption keys in a secure repository which enables the recovery of ransomware‐infected systems and ransomware‐encrypted files. The proposed technique can be used to repair systems infected by ransomware, thereby ensuring safety against such malicious codes.
Effect of age on the enteric nervous system of the human colon

Abstract The effect of age on the anatomy and function of the human colon is incompletely understood. The prevalence of disorders in adults such as constipation increase with age but it is unclear if this is due to confounding factors or age‐related structural defects. The aim of this study was to determine number and subtypes of enteric neurons and neuronal volumes in the human colon of different ages. Normal colon (descending and sigmoid) from 16 patients (nine male) was studied; ages 33–99. Antibodies to HuC/D, choline acetyltransferase (ChAT), neuronal nitric oxide synthase (nNOS), and protein gene product 9.5 were used. Effect of age was determined by testing for linear trends using regression analysis. In the myenteric plexus, number of Hu‐positive neurons declined with age (slope = −1.3 neurons/mm/10 years, P = 0.03). The number of ChAT‐positive neurons also declined with age (slope = −1.1 neurons/mm/10 years of age, P = 0.02). The number of nNOS‐positive neurons did not decline with age. As a result, the ratio of nNOS to Hu increased (slope = 0.03 per 10 years of age, P = 0.01). In the submucosal plexus, the number of neurons did not decline with age (slope = −0.3 neurons/mm/10 years, P = 0.09). Volume of nerve fibres in the circular muscle and volume of neuronal structures in the myenteric plexus did not change with age. In conclusion, the number of neurons in the human colon declines with age with sparing of nNOS‐positive neurons. This change was not accompanied by changes in total volume of neuronal structures suggesting compensatory changes in the remaining neurons.
Novel fiber tip sensor potentially suitable for gastric pH measurement

Monitoring pH for long periods, usually 24 h, in the stomach and in the esophagus may be essential in the diagnosis of gastro-esophageal diseases. The clinical range of interest is quite extended, between 1 to 8 pH units. Methyl red, after its covalent immobilization on controlled pore glass (CPG), is characterized by a working range which fits well with the clinical one. A novel probe, suitable for gastro-esophageal applications, was designed in order to optimize the performances of the colored CPG. This leads to a very simple probe configuration characterized by a very fast response.
Scan architecture for shift and capture cycle power reduction

Low power design techniques have been employed for more than two decades, however an emerging problem is satisfying the test power constraints for avoiding destructive test and improving the yield. Scan architectures represent the most used approach for testing digital integrated circuits. While several methods have been proposed for reducing the power dissipation due to scan shifting, very little work has been done towards reducing the power dissipation during the capture cycles. This paper proposes a method of transforming a typical scan architecture for reducing the power dissipation during both the shifting cycle and the capture cycle. The basic idea is to split the the scan chain into multiple length-balanced partitions and to enable only one partition at each test clock. This way, instead of having all the scan cells active at the same time, only a fraction of them will be active in each test clock cycle, which will reduce substantially the power dissipation in the circuit under test. Unlike previously proposed methods for shifting power reduction based on scan chain partitioning which use a single capture clock per test cycle, our approach uses multiple capture clocks per test cycle, which allows enabling only a fraction of the scan chain during each shift or capture clock, thus reducing the switching activity in the circuit under test not only during shifting but also during capture. Therefore, the proposed method represents an unified solution for reducing both shifting and capture power dissipation during scan-based test. The proposed method also allows full reuse of the test vectors of the original scan architecture.
Vulnerability of Drinking-Water Wells in La Crosse, Wisconsin, to Enteric-Virus Contamination from Surface Water Contributions

ABSTRACT Human enteric viruses can contaminate municipal drinking-water wells, but few studies have examined the routes by which viruses enter these wells. In the present study, the objective was to monitor the municipal wells of La Crosse, Wisconsin, for enteric viruses and determine whether the amount of Mississippi River water infiltrating the wells was related to the frequency of virus detection. From March 2001 to February 2002, one river water site and four wells predicted by hydrogeological modeling to have variable degrees of surface water contributions were sampled monthly for enteric viruses, microbial indicators of sanitary quality, and oxygen and hydrogen isotopes. 18O/16O and 2H/1H ratios were used to determine the level of surface water contributions. All samples were collected prior to chlorination at the wellhead. By reverse transcription-PCR (RT-PCR), 24 of 48 municipal well water samples (50%) were positive for enteric viruses, including enteroviruses, rotavirus, hepatitis A virus (HAV), and noroviruses. Of 12 river water samples, 10 (83%) were virus positive by RT-PCR. Viable enteroviruses were not detected by cell culture in the well samples, although three well samples were positive for culturable HAV. Enteroviruses detected in the wells by RT-PCR were identified as several serotypes of echoviruses and group A and group B coxsackieviruses. None of the well water samples was positive for indicators of sanitary quality, namely male-specific and somatic coliphages, total coliform bacteria, Escherichia coli, and fecal enterococci. Contrary to expectations, viruses were found in all wells regardless of the level of surface water contributions. This result suggests that there were other unidentified sources, in addition to surface water, responsible for the contamination.
Measures of clinical significance.

Behavioral scientists are interested in answering three basic questions when examining the relationships between variables (Kirk, 2001). First, is an observed result real or should it be attributed to chance (i.e., statistical significance)? Second, if the result is real, how large is it (i.e., effect size)? Third, is the result large enough to be meaningful and useful (i.e., clinical or practical significance)? In this last column in the series, we treat clinical significance as equivalent to practical significance. Judgments by the researcher and the consumers (e.g., clinicians and patients) regarding clinical significance consider factors such as clinical benefit, cost, and side effects. Although there is no formal statistical test of clinical significance, researchers suggest using one of three types of effect size measures to assist in interpreting clinical significance. These include the strength of association between variables (r family effect size measures), the magnitude of the difference between treatment and comparison groups (d family effect size measures), and measures of risk potency. In this paper, we review the d and r effect size measures and five measures of risk potency: odds ratio, risk ratio, relative risk reduction, risk difference, and number needed to treat. Finally, we review a relatively new effect size, AUC (which for historical reasons irrelevant to the current discussion stands for area under the receiver operating characteristic [ROC] curve), that integrates many of the others and is directly related to clinical significance. Each of these measures, however, has limitations that require the clinician to be cautious about interpretation. Guidelines are offered to facilitate the interpretation and understanding of clinical significance. Problems With Statistical Significance
Whole-Cell Currents from Nonculfured Human Lens Epithelium

Perforated patch techniques were used to measure whole-cell ionic currents in freshly dissociated human lens epithelial cells that had not been subjected to culture media or serum. With a 150 mmol/1 K internal solution, the cells had resting voltages of-27.4 ± 4.7 mV (mean ± standard deviation [SD)) and capacitances of 10.4 ± 2.8 pF (mean ± SD). The input resistance of the cells was 1.6 ± 0.7 Gfi (mean ± SD) at large negative voltages. A delayed outwardly rectifying K current was found in most cells studied. Current magnitudes of 1-2 nA at +80 mV were common. The current had selectivities, activation time constants, deactivation time constants, open probability versus voltage relationships, and inactivations similar to those of the delayed rectifying K current found in many cell types and studied previously in cultured human lens epithelium. These results verify the existence, at high density, of these currents in noncultured human epithelial cells. Invest Ophthalmol Vis Sci 33:22622268,1992
Neuroticism and polymorphisms in the serotonin transporter gene

Background. There is evidence for an association between two different polymorphisms of the human serotonin transporter gene (5-HTT) and the personality trait of neuroticism and affective disorder. Methods. We studied the association between neuroticism and polymorphisms in the 5HTT-linked promoter region and in a variable number tandem repeat region (VNTR) of the 5-HTT gene in 204 people aged over 60 derived from a random sample of men and women in the general population. Approximately half of the subjects were in the top 20% of neuroticism scorers and half in the bottom 20%. Results. There were no significant differences in allelic or genotypic frequencies between the high and low neuroticism scorers. There was highly significant linkage disequilibrium between the two 5-HTT gene polymorphisms, and haplotype analysis showed no association between neuroticism level and haplotype. Conclusions. Reports of an association between two 5-HTT gene polymorphisms and the personality trait of neuroticism are not supported by these results.
Analysis of Mycobacterium tuberculosis Genotypes in Madrid and Identification of Two New Families Specific to Spain-Related Settings

ABSTRACT In Spain, tuberculosis (TB) patterns are changing because of the recent increase in the number of cases among immigrants. To establish the composition of circulating Mycobacterium tuberculosis strains before the effects of foreign strains appear, this study focused on molecular characterization of 233 patient isolates using spoligotyping. The spoligotyping data were further analyzed using an international database, SpolDB4. The results obtained showed that the general features of the M. tuberculosis population in Spain are coherent with those of other European countries, with the Latin American and Mediterranean group, and with the Haarlem 3 and T1 families as the most prevalent genotypes. The Spanish isolates clustered mostly with genotypes which had previously been isolated in countries linked with Spain. We also describe and fully characterize two novel M. tuberculosis families, Madrid1 and Madrid2, which are specific to Spain-related settings. The data reported here provide a solid reference when monitoring changes in the composition of the M. tuberculosis population in Spain as a consequence of the increasing rate of TB in the foreign population.
Analytical Method of Distributed Generation on Static Voltage Stability

It can’t be ignored that the impact of distribution network to the static voltage stability of the distributed generation. In this paper, we first introduce the stability indices of the traditional grid on static voltage and the analytical method, at the same time, we put forward the corresponding advantages, disadvantages and applicable scope. Then, we present a summary of the current research on the impact of distribution network to the static voltage stability of the distributed generation at home and abroad from the two aspects of the static voltage stability indices and analytical methods. At last, the paper points out a new way to improve the distribution network static voltage stability that with the consistency theory to achieve coordinated control of distributed generation, microgrid, as well as virtual power plants, which will be more advanced. This article has a reference value for the analysis of the impact of distributed generation on static voltage stability of the distribution network, as well as researches the measures to improve the static stability.