Miracle-dz/UniFAR-FTUs huggingface dataset:
Prediction of Recurrence Patterns in Glioblastoma Using DSC-MRI Radiomics-Based Deep Learning

Glioblastoma remains the most devastating brain tumor despite optimal treatment, because of the high rate of recurrence. Distant recurrence has distinct genomic alterations compared to local recurrence, which requires different treatment planning both in clinical practice and trials. To date, perfusion-weighted MRI has revealed that perfusional characteristics of tumor are associated with prognosis. However, not much research has focused on recurrence patterns in glioblastoma: namely, local and distant recurrence. Here, we propose two different neural network models to predict the recurrence patterns in glioblastoma that utilizes high-dimensional radiomic profiles based on perfusion MRI: area under the curve (AUC) (95% confidence interval), 0.969 (0.903-1.000) for local recurrence; 0.864 (0.726-0.976) for distant recurrence for each patient in the validation set. This creates an opportunity to provide personalized medicine in contrast to studies investigating only group differences. Moreover, interpretable deep learning identified that salient radiomic features for each recurrence pattern are related to perfusional intratumoral heterogeneity. We also demonstrated that the combined salient radiomic features, or “radiomic risk score”, increased risk of recurrence/progression (hazard ratio, 1.61; p=0.03) in multivariate Cox regression on progression-free survival.
A deep Westerbork survey of areas with multicolor Mayall 4 M plates. I - The 1412 MHz catalogue, source counts and angular size statistics

A la resolution de 12,5″ environ 30% de toutes les sources sont resolues, necessitant un algorithme complique pour calculer les positions des sources, les flux, les dimensions angulaires et les angles de position. Les tables contiennent 471 sources parmi lesquelles 306 constituent un echantillon complet bien defini
Symbol Error Rate Analysis of Adaptive Threshold Based Relay Selection with 2-Bits Feedback for Type-2 Relays

—In this paper, we address the performance analysis of the extended adaptive threshold based relay selection (ATRS) scheme for multiple type-2 relays. More speciﬁcally, the symbol error rate (SER) analysis of 2-bits feedback based ATRS scheme is presented. For validation of our analytical results, derived analytical results are cross-veriﬁed with results obtained via Monte-Carlo simulations. Some selected results show that with more reﬁned feedback information, the potential performance degradation caused by the minimum (i.e., 1-bit) feedback can be compensated, especially with a 1-bit increase in terms of feedback data rate and additional single comparison process in terms of complexity.
Methods for Identifying Candidate Genes for Cardiovascular Diseases by using Microarrays

Microarrays present new powerful technique for high-throughput, global transcriptomic proﬁling of gene expression. It permits to investigate the expression levels of thousands of genes simultaneously. The global snapshots of gene expression, both among different cell types and among different states of a particular cell type can help in identifying candidate genes that may be involved in a variety of normal or disease processes. This promises to provide insight into the pathophysiology of human syndromes such as cardiovascular diseases, whose etiologies are due to multiple genetic factors and their interaction with the environment. Microarrays also present new statistical and bioinformatical problems because the data are very high dimensional with very little replication. Almost all research employing microarray expression analysis depends heavily on statistical analysis to extract the most useful information from the huge number of data points generated. The aim of this paper is to present possibilities of use of microarrays for identifying candidate genes for cardiovascular diseases and specially attention is devoted to statistical methods for identifying differentially expressed genes from microarray data.
COPD_A_279293 2837..2846

1Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland; 2Institute of Primary Care, University of Zurich, Zurich, Switzerland Background and Objective: Limited evidence on long-term effects of physical activity programs in COPD is available. The aim of the study was to investigate the effects of a threemonth program combining physical activity counselling and pedometer-based feedback in addition to usual care, followed by a nine-month unsupervised observation period as compared to usual care in participants with severe to very severe COPD. Methods: Participants were randomized to either a control group receiving usual care or an intervention group receiving motivational support, an activity diary with an individual step count goal (ie, an increase of ≥15% from baseline) and a pedometer in addition to usual care. The intervention ended after three months and an unsupervised observational period followed until twelve months. Primary outcome was daily step count after one year. Results: Seventy-four participants were included, 61 (82%) completed the study. Linear regression modelling, adjusted for baseline step count, showed no significant difference in change in step count after 12 months between the groups (Β = 547.33, 95% CI = −243.55/1338.20). Conclusion: A three-month program combining physical activity counselling and pedometer-based feedback in addition to usual care does not attenuate the declining course of physical activity in participants with severe and very severe COPD during a long term follow-up of one year as compared to usual care. This result was primarily determined by the low intervention response rates to the combined program. Clinical Trial Registration: www.ClinicalTrials. gov, NCT03114241.
1 Title: Aptamer-mediated blockade of IL4R(cid:2) triggers apoptosis of MDSCs and limits tumor progression.

In addition to promoting progression myeloid-derived suppressor cells (MDSC) and tumor-associated macrophage (TAM) also inhibit antitumor T cell functions and limit the efficacy of immunotherapeutic interventions. Despite the importance of these leukocyte populations, a simple method for their specific depletion has not been developed. In this study, we generated an RNA aptamer that blocks the murine or human IL4 receptor-(cid:2) (IL4R(cid:2) or CD124) that is critical for MDSC suppression function. In tumor bearing mice, this anti-IL4R(cid:2) aptamer preferentially targeted MDSC and TAM and unexpectedly promoted their elimination, an effect that was associated with an increased number of tumor-infiltrating T cells and a reduction in tumor growth. Mechanistic investigations of aptamer-triggered apoptosis in MDSC confirmed the importance of IL4Ra-STAT6 pathway activation in MDSC survival. Our findings define a straightforward strategy to deplete MDSCs and TAMs in vivo and they strengthen the concept IL4R(cid:2) signaling is pivotal for MDSC survival. More broadly, these findings suggest therapeutic strategies based on IL4R(cid:2) signaling blockades to arrest an important cellular mechanism of tumoral immune escape mediated by MDSC and TAM in cancer. these data suggest that IL4R(cid:2) expression and its engagement could promote pro-survival signaling in MDSCs, and that the anti-IL4R(cid:2) aptamer can counteract this effect.
Myristoylation Is Required for Human Immunodeﬁciency Virus Type 1 Gag-Gag Multimerization in Mammalian Cells (cid:1)

The Gag protein of human immunodeﬁciency virus type 1 directs the virion assembly process. Gag proteins must extensively multimerize during the formation of the spherical immature virion shell. In vitro, virus-like particles can be generated from Gag proteins that lack the N-terminal myristic acid modiﬁcation or the nucleocapsid (NC) protein. The precise requirements for Gag-Gag multimerization under conditions present in mammalian cells, however, have not been fully elucidated. In this study, a Gag-Gag multimerization assay measuring ﬂuorescence resonance energy transfer was employed to deﬁne the Gag domains that are essential for homomultimerization. Three essential components were identiﬁed: protein-protein interactions contrib- uted by residues within both the N- and C-terminal domains of capsid (CA), basic residues in NC, and the presence of myristic acid. The requirement of myristic acid for multimerization was reproduced using the heterologous myristoylation sequence from v- src . Only when a leucine zipper dimerization motif was placed in the position of NC was a nonmyristoylated Gag protein able to multimerize. These results support a three- component model for Gag-Gag multimerization that includes membrane interactions mediated by the myristoylated N terminus of Gag, protein-protein interactions between CA domains, and NC-RNA interactions. Human immunodeﬁciency virus type 1 (HIV-1) particles assemble on cellular membranes. Pr55 Gag (Gag) is a precursor polyprotein that drives the assembly
Deformation and strength characteristics of Laves phases in Deformation and strength characteristics of Laves phases in titanium alloys titanium alloys

ThesuperiorreinforcementnatureofLavesphasesmakethemsuitableforhigh-strengthapplications.Therefore, investigations on the deformation and strength characteristics of Laves phases are useful in development of an improved Laves phase-reinforced alloy. In this work, the Vickers micro-indentation method is used to evaluate and compare the deformation and strength characteristics of a hexagonal close-packed Laves phase (C14-type) inTi-35Zr-5Fe-6Mn(wt%)andaface-centeredcubicLavesphase(C15-type)inTi-33Zr-7Fe-4Cr(wt%),consider- ing the same volume fraction of Laves phase (~7.0%) in these alloys. Moreover, the effects of higher volume fraction of Lavesphase (19.4%)onindentation-based deformation featuresare evaluatedinTi-35Zr-5Fe-8Mn(wt%). Remarkably, dislocation activity and plastic deformation features are evident in the C15-type Laves phase, whereas the C14-type Laves phase strongly blocks dislocation motion. Therefore, the C15-type Laves phase im- proves plastic deformability, whereas the C14-type Laves phase improves strength characteristics of Laves phase-reinforced alloys. © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Measuring SMEs Performance Holistically Includes Financial, Non-Financial and Social Aspects

----------------------------------Abstract: SMEs has a real role as one of the driving factors for economic growth in several countries. Therefore, it is very important to know the condition of SMEs through performance measurement. The purpose of this paper is to examine how to measure the performance of SMEs in a holistic manner. Therefore, three aspects are used as an approach, namely financial, non-financial, and social aspects. The measurement of business performance needs to be done holistically and comprehensively. Various performance measurement techniques continue to evolve along with the orientation of the success of an enterprise. One of the adjustments or supplements to measuring business performance is to include social elements as one aspect of performance, in addition to financial aspects (financial performance) and non-financial aspects (customer perspective, learning and growth).
following motor skill learning during mental in stroke.

Background and Purpose— Mental practice (MP), which involves cognitive rehearsal of physical movements, is a non-invasive, inexpensive method of enabling repetitive, task specific practice (RTP). Recent, randomized controlled data suggest that MP, when combined with a RTP therapy program, increases affected arm use and function significantly more than RTP only. As a next step, this 10-subject case series examined the possibility that cortical plasticity is a mechanism underlying the treatment effect of MP when combined with RTP. Method— 10 chronic stroke patients (mean = 36.7 months) exhibiting stable, moderate motor deficits received ½ hour therapy sessions for their affected arms, occurring 3 days/week for 10 weeks, and emphasizing valued activities of daily living (ADLs). Directly after therapy, subjects received 30-minute MP sessions, which required MP of the ADLs performed during therapy. Behavioral outcomes were blindly evaluated using the Action Research Arm Test (ARAT) and the Fugl-Meyer Assessment (FM). Functional magnetic resonance imaging (fMRI) was administered before and after intervention to assess cortical changes. Results— Before intervention, subjects exhibited stable motor deficits. After intervention, subjects exhibited marked ARAT and FM score increases (+ 5.3 and + 4.2, respectively), and clinically significant, new abilities to perform valued ADLs. Post-intervention fMRI revealed significant increases in activation to wrist flexion and extension of the affected hand in the premotor area and primary motor cortex ipsi- and contralaterally to the affected hand, and superior parietal cortex ipsilateral to the affected hand. Decreased activations were noted in parietal cortex
Galanthamine and other Amaryllidaceae related alkaloids are inhibitors of (cid:2) 7, (cid:2) 4 (cid:3) 2 and (cid:2) 3 (cid:3) 4 nicotinic acetylcholine receptors

Galanthamine is an Amaryllidaceae-derived acetylcholinesterase inhibitor used to treat memory impair- ment in Alzheimer’s disease and vascular dementia. There is evidence that galanthamine, in addition to its effects on acetylcholinesterase, may enhance or inhibit brain nicotinic acetylcholine receptors, which could increase or decrease the therapeutic efﬁcacy of galanthamine, respectively. Here, we evaluated the effects of galanthamine and two others Amaryllidaceae acetylcholinesterase inhibitors (haemanthamine and tazettine) analyzed by gas chromatography–mass spectrometry and identiﬁed by comparing their mass fragmentation patterns with literature and database NIST vs.2.0 on the agonist responses of brain nicotinic acetylcholine receptors (cid:2) 7, (cid:2) 3 (cid:3) 4, ( (cid:2) 4) 2 ( (cid:3) 2) 3 and ( (cid:2) 4) 3 ( (cid:3) 2) 2 . Using nicotinic acetylcholine receptors expressed heterologously in Xenopus oocytes, in conjunction with two-electrode voltage clamp- ing, we found that galanthamine inhibits the function of nicotinic acetylcholine receptors assayed through a mix competitive and non-competitevely. Nicotinic acetylcholine receptor (cid:2) 7 were signiﬁcantly more sensitive to inhibition (17 ± 0.6 (cid:4) M) than the heteromeric receptor, (cid:2) 3 (cid:3) 4 (90 ± 3.4 (cid:4) M). Neither haemanthamine nor tazettine were more potent than galanthamine. The well-known Amaryllidaceae alkaloids galanthamine, haemanthamine and tazettine were analyzed by coupled GC-MS with electron impact ionization (70 eV) using an Agilent, model 7890A chromatograph equipped with a HP-5 ms capillary column (30 m by 0.25 mm by 0.25 (cid:4) m; J&W Scientiﬁc) with helium carrier gas. The GC oven was programmed to ramp from 100 ◦ C (for 3 min) to 280 ◦ C at 10 ◦ C/min and held for 19 min. The injector and transfer line temperatures were 250 ◦ C and 285 ◦ C, respectively. The alkaloid compounds were identiﬁed by comparing their gas chromatog-raphy mass spectra with data from the NIST mass spectrometry Search 2.0 library, Kovats indices (RI) and mass spectra reported in the literature (Ortiz et al., 2012). The Kovats retention indexes of the compounds were recorded with standard of an n-hydrocarbon mixture (C 9 -C 26 ). The proportion of each alkaloid in the basic extracts is expressed as a percentage of ion current (TIC).
Sexual Dysfunction and Preferences for Discussing Sexual Health Concerns Among Veteran Primary Care Patients

Background: Sexual health is an important, yet often overlooked, aspect of overall health. Veterans may be particularly at risk for sexual dysfunction. The objectives of this study were to assess the prevalence and correlates of sexual dysfunction and examine preferences among veterans for discussing sexual problems. Methods: In this cross-sectional study, we mailed 1500 surveys to a random sample of primary care patients from 3 Veterans Affairs medical centers; 313 were returned (21% response rate) and 248 had complete data. Veterans (M age = 49.4 years) were mostly White (86.7%), women (60.9%), and married (79.0%). The Arizona Sexual Experience Scale was used to screen for sexual dysfunction. Results: Half of veterans, 62.3% of women and 32.0% of men, screened positive for sexual dysfunction. More than 60% of veterans agreed that the primary care team should provide information, proactively ask, and inquire on medical history forms about sexual problems; 59.3% were open to meeting with behavioral health providers. Conclusions: Primary care providers should ask veterans about sexual health, as sexual dysfunction was prevalent, especially among women and among men over age 65. Most veterans were receptive to being asked about sexual problems in primary care and preferred to be asked rather than bring it up. ( J Am Board Fam Med 2021;34:357–367.)
Di V erentially expressed genes during malting and correlation with malting quality phenotypes in barley ( Hordeum vulgare L.)

Breeding for malting quality is an important goal of malting barley breeding programs. Malting quality is a complex phenotype that combines a large number of interrelated components, each of which shows complex inheritance. Currently, only a few genes involved in determining malting quality have been characterized. We combined transcript pro W ling with phenotypic correlations to identify candidate genes for malting quality. The Barley1 GeneChip ® array containing 22,792 probe sets was used to conduct transcript pro W ling of genes expressed in several di V erent stages of malting of four malting cultivars. Genes that were di V erentially expressed in comparisons between di V erent malting stages relative to ungerminated seed, as well as in comparisons between malting cultivars in the same malting stage were identi W ed. Correlation analysis of 723 di V erentially expressed genes with malting quality phenotypes showed that 11–102 of these genes correlated with six malting quality phenotypes. Genes involved in carbohydrate metabolism were among the positively correlated genes. Genes for protein and lipid metabolism, cell wall organization and biogenesis, and genes involved in stress and defense response also correlated with malting quality phenotypes. Expressed sequence tags (ESTs) were generated from a ‘malting-gene enriched’ cDNA library made by suppression subtractive hybridization between malted and ungerminated seeds of ‘Morex’.
Reciprocity Dynamics of Psychological Contract Breach and Perceived Organisational Support on Job Involvement of Private and Public Organizations

Organisational researchers believe that there is norm of reciprocity between the employers and employees. This study examined two measures of organization’s contribution to reciprocity dynamic with employees which are psychological contract breach and perceived organisational support on job involvement in public and private organizations in Abuja. Two hundred participants were selected using purposive sampling technique in a cross sectional survey that utilised ex-post facto research design; and two hypotheses were tested using three standardised psychological scales. Data collected were analysed using multiple regression and independent t-test. The results showed 3.2% variance of psychological contract breach and perceived organizational support on job involvement. Employees in the public organizations had higher score on job involvement than employees in public organizations. Implication of study was discussed in line with attitude change and national development.
A Comparative Study of TiO 2 Paste Preparation Methods Using Solvothermally Synthesised Anatase Nanoparticles in Dye-Sensitised Solar Cells

Featured Application: Dye-sensitized Solar Cells may be employed as photovoltaic power windows, owing to the use of transparent electrodes and the partial transparency of the light absorbing medium (dyes). Abstract: Dye-sensitised solar cells continue to be a promising photovoltaic technology for indoor and outdoor applications, with increased interest in power window applications integrated into buildings. This results from properties not seen in other, more established solar technologies, such as the range of available colours, partial transparency and good performance under low light intensities or in partial shade. In spite of the attractiveness of this application and the commercial availability of suitable non-scattering TiO 2 materials, the vast majority of new TiO 2 materials being developed and reported in the literature are dried prior to being made into a paste and subsequently into photoanode ﬁlms. Here, we make a detailed side-by-side comparison of different paste-forming techniques, with one yielding scattering ﬁlms, and the other yielding non-scattering ﬁlms. Devices utilising the organic dye D149 showed comparable performance using both approaches (6.9% photovoltaic conversion efﬁciency (PCE) with drying versus 6.4% PCE without drying), while the difference was slightly more marked with the dye N719 (7.7% PCE versus 6.8% PCE), suggesting that the trade-off in light harvesting required for power windows may be acceptably small. We also discuss ways by which these differences may be further decreased.
Data Minability Evaluation by Compression – An Experimental Study

—The effectiveness of compression algorithms is increasing as the data subjected to compression contains patterns which occur with a certain regularity. This basic idea is used to detect the existence of regularities in various types of data ranging from market basket data to undirected graphs. The results are quite independent of the particular algorithms used for compression and offer an indication of the potential of discovering patterns in data before the actual mining process takes place.
RRU_A_331506 749..757

Department of Urology, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA Purpose: Prostate cancer (PCa) is the most common non-skin cancer in men worldwide and more than 80% of men with PCa also have histo-anatomical findings of benign prostate hyperplasia (BPH). It is well documented that BPH develops in the transition zone (TZ), whereas 80–85% of PCa originates in the peripheral zone (PZ) of the prostate. Possible causal links between both disease entities are controversially discussed in the current literature. Some studies have reported that larger prostates have a decreased incidence of PCa compared to smaller prostates. The purpose of this systematic review is to comprehensively summarize studies analyzing any association between prostate gland volume and incidence of PCa. Methods: A thorough literature review was performed between 01.01. 1990 through 02.28. 2020 using PubMed and applying the “PRISMA” guidelines. Inclusion and exclusion criteria were defined. Results: Our systematic review found 41 articles reporting an inverse (negative) relationship between prostate gland volume and incidence of prostate cancer. Sample sizes ranged from 114 to 6692 patients in these single institutional and multi-institutional studies. Thirty-nine (95%) of the 41 articles showed a statistically significant inverse relationship. In our search, no study was found showing a positive correlation between BPH size and the incidence of PCa. Conclusion: To our knowledge, this is the first systematic review on the important clinical question of interaction between prostate size and the incidence of PCa. The results are demonstrating an inverse relationship, and therefore reveal strong evidence that large prostates may be protective of PCa when compared to smaller prostates.