Miracle-dz/UniFAR-FTUs huggingface dataset:
BOOSTING FOR HIGH-MULTIVARIATE RESPONSES IN HIGH-DIMENSIONAL LINEAR REGRESSION

We propose a boosting method, multivariate L2Boosting, for multivari- ate linear regression based on some squared error loss for multivariate data. It can be applied to multivariate linear regression with continuous responses and to vector autoregressive time series. We prove, for i.i. d. as well as time series data, that multivariate L2Boosting can consistently recover sparse high-dimensional mul- tivariate linear functions, even when the number of predictor variables pn and the dimension of the response qn grow almost exponentially with sample size n, pn = qn = O(exp(Cn 1 )) (0 < < 1, 0 < C <1), but the '1-norm of the true underlying function is nite. Our theory seems to be among the rst to address the issue of large dimension of the response variable; the relevance of such settings is briey outlined. We also identify empirically some cases where our multivari- ate L2Boosting is better than multiple application of univariate methods to single response components, thus demonstrating that the multivariate approach can be very useful.
Postoperative Changes in Olfactory Function After Transcanalicular Diode Laser Dacryocystorhinostomy

Purpose: Transcanalicular diode laser dacryocystorhinostomy (TCL-DCR) is used much in recent years for the surgery of nasolacrimal duct obstruction (NLDO). Although TCL-DCR is accepted to be minimally invasive, safe, and effective, there is no report focusing on postoperative changes in olfactory function after this procedure. Hence, the aim of this current study was to investigate the changes in olfactory function after TCL-DCR procedure. Materials and Methods: This study was carried out in 42 volunteers (16 men and 26 women) between the ages of 20 and 81 years. All participants received detailed lateralized olfactory tests preoperatively and at the postoperative first week, first month, third month, and sixth month. After lateralized olfactory tests were performed, the results were grouped according to the side of the nasal passage where the operation was performed for NLDO: the nonoperated side served as the control. Results: The current investigation produced 2 major findings: (1) olfactory function decreased significantly after TCL-DCR procedure at the operated side of the nose compared with the nonoperated side; (2) olfactory abilities of the patients returned to normal within 3 months. Conclusion: The results of this study showed that transcanalicular diode laser could be used safely in terms of olfactory function for dacryocystorhinostomy. Temporary decrease of olfactory function on the side having TCL-DCR should be taken into account when obtaining informed patient consent.
Road to 2020: IS-Supported Business Models for Electric Mobility and Electrical Energy Markets

Electric mobility is on the rise, as many countries such as the United States of America, Germany, and China intend to bring one million electric cars onto their streets by 2020. This opens up perspectives on new business models, including aggregators for electric vehicles that enter ancillary services energy markets. These intermediaries are of particular interest to the IS discipline, since their market position links research on decision support, electronic markets and energy informatics. In this paper we present a research agenda to analyze IS-supported business models that cover the entire value chain of such an intermediary. We argue that IS can enhance decision making in the auctions for ancillary energy by improving forecasts of maximum energy prices. Additionally, IS facilitates electronic auctions and scheduling mechanisms that enable the intermediary to aggregate numerous electric vehicles.
The role of personality and coping style in relation to awareness of current functioning in early-stage dementia

This study investigated the role of psychological factors in unawareness in early-stage dementia, focusing on personality and coping strategies. Forty-nine individuals with a ‘non-frontal’ dementia and their partners completed standardized self-report questionnaires. Multiple regression analyses indicated that personality factors, in particular negative attitudes towards emotional expression, were related to avoidant coping in managing the threat of dementia. Neither negative attitudes towards emotional expression nor avoidant behavioural coping related to unawareness after controlling for relevant disease-related and emotional variables. However, a relationship was found between conscientiousness and unawareness. The findings were interpreted with reference to literature on processes of denial and a distinction between conscious behavioural avoidance and unconscious defensive denial was made. Implications for clinical practice were considered.
A medradio-band low-energy-per-bit CMOS OOK transceiver for implantable medical devices

A 2-Mbps 400-MHz On-Off Keying (OOK) transceiver implemented in 0.18-µm CMOS technology for implantable epilepsy devices is presented. The proposed transceiver is composed of voltage control oscillator (VCO) and OOK function generator in the transmitter part, and new current-mode envelope detector and cascaded gain amplifiers in the receiver part. The fabricated transmitter has power consumption of 0.84 mW and energy consumption of 0.42 nJ per bit. The fabricated receiver has power consumption of 0.59 mW and energy consumption of 0.295 nJ per bit. The sensitivity of receiver is −45 dBm.
Patient concerns posthaemorrhagic stroke: a study of the Internet narratives of patients with ruptured arteriovenous malformation.

AIMS To identify and describe the experiences and concerns of a sample of young haemorrhagic stroke patients who experienced a ruptured arteriovenous malformation and determine whether there are gender differences. BACKGROUND Patients with arteriovenous malformation haemorrhage tend to be young adults, but little is known about their experiences and concerns. Some research suggest that there is a need to take gender into account when investigating their experiences and concerns. DESIGN A content analysis of a sample of narratives posted by survivors of an arteriovenous malformation haemorrhage on an Internet site, to determine the extent to which writers discuss similar concerns and experiences. METHODS The sample consists of 83 narratives. The author and a research assistant carefully considered the content of each narrative, created categories based upon this reading and then coded men and women's narratives separately, according to the topic discussed. RESULTS Five main categories of topics were identified: 'symptoms', 'doctors and hospitals', 'rehabilitation and recovery', 'disabilities' and 'miscellaneous reflections'. The latter category contained the sub-categories 'arteriovenous malformation website', 'thanks', 'life now' and 'feelings'. Narratives varied greatly regarding how much each topic was addressed, but there were few gender differences. Overall, most attention was paid to discussing doctors and hospitals and most writers also paid significant attention to the importance of being able to share experiences with other survivors. CONCLUSIONS For these narrators, the experience of being evaluated and treated for arteriovenous malformation haemorrhage is traumatic, leaves a lasting impact and men and women share similar concerns and experiences. Narrators show a need to talk about their experiences, especially with others who may share similar experiences. RELEVANCE TO CLINICAL PRACTICE Knowing the concerns and perspectives of a sample of arteriovenous malformation patients may help nurses anticipate the concerns of their own haemorrhagic stroke patients and help improve patients' psychosocial well-being.
We should desist using RECIST, at least in GIST.

PURPOSE Response Evaluation Criteria in Solid Tumors (RECIST) are insensitive in evaluating imatinib-treated gastrointestinal stromal tumors (GISTs). Response by Choi criteria, a 10% decrease in size or a 15% decrease in density on contrast-enhanced CT, correlated well in a small training set of patients who showed response as measured by positron emission tomography, and was more predictive of time to tumor progression (TTP) than response by RECIST. This study was designed to validate these observations in an independent data set. PATIENTS AND METHODS Fifty-eight patients with imatinib-treated GISTs were evaluated by RECIST and Choi criteria. TTP was compared with TTP in the training set. Patients were analyzed initially with follow-up to 28 months, extended to 60 months for survival analysis. RESULTS Patients who met Choi response criteria on CT at 2 months had significantly better TTP than those who did not (P = .0002), whereas response group by RECIST was not significantly correlated with TTP. Even when the 98 patients from both sets were analyzed together, the response group by RECIST did not correlate significantly with TTP, whereas response group by Choi criteria did correlate significantly with TTP. Disease-specific survival (DSS) was also significantly correlated with response group by Choi criteria (P = .04), but not with response group by RECIST. CONCLUSION Choi response criteria are reproducible, more sensitive, and more precise than RECIST in assessing the response of GISTs to imatinib mesylate. Response by Choi criteria, unlike response by RECIST, correlates significantly with TTP and DSS. Response by Choi criteria should be incorporated routinely into future studies of GIST therapy. We should desist using RECIST, at least in GIST.
Protease substrate profiling using bacterial display of self‐blocking affinity proteins and flow‐cytometric sorting

Proteases are involved in fundamental biological processes and are important tools in both biotechnological and biomedical research. An important property of proteases is to discriminate among potential substrates. Here, a new method for substrate profiling of proteases is presented. The substrates are displayed between two anti‐idiotypic affinity domains on the Gram‐positive bacterium Staphylococcus carnosus. The first domain functions as a reporter tag and has affinity for a labeled reporter protein, whereas the second domain blocks the reporter tag from interacting with the reporter protein. Site‐specific proteolysis of the substrate results in release of the blocking domain, enabling the reporter tag to bind the labeled reporter protein. Proteolysis is therefore reflected in reporter binding, which is quantified by flow cytometry. First, the method with tobacco etch virus protease (TEVp) is evaluated and then the substrate preference of matrix metalloprotease‐1 (MMP‐1) is determined using two libraries of around three million substrates each. Identified substrate peptides contained the previously reported motif (PXXXHy) and on‐cell determination of apparent kcat/KM revealed that the enriched substrate peptides are hydrolyzed six to eight‐fold more efficiently than a previously reported substrate peptide. The method thus works as intended and the authors believe it has potential as an efficient tool for substrate profiling.
Which photo groups should I choose? A comparative study of recommendation algorithms in Flickr

Over the last few years, the social media site Flickr has gained massive popularity. Besides traditional operations on photo sharing, Flickr also offers millions of groups for users to join in order to share photos with others, and the number of groups still increases daily. Choosing among so many options is challenging for users. As such, helping users easily find their desirable groups has become increasingly important. In this paper, we provide a systematic experimental evaluation of several collaborative filtering algorithms to recommend groups for Flickr users. In particular, we design and compare seven Flickr group recommendation models: three memory-based models and four model-based models. Our results suggest that model-based approaches are beneficial compared with memory-based approaches in terms of top- k recommendation metric. Models with tags perform well for sparse data, whereas models without tags are more suitable for dense data. Furthermore, incorporating tags in the recommendation algorithms leads to an improvement of precision on the top 2% performance.
Thinking high but feeling low: An exploratory cluster analysis investigating how implicit and explicit spider fear co-vary

ABSTRACT Research has demonstrated large differences in the degree to which direct and indirect measures predict each other and variables including behavioural approach and attentional bias. We investigated whether individual differences in the co-variance of “implicit” and “explicit” spider fear exist, and whether this covariation exerts an effect on spider fear-related outcomes. One hundred and thirty-two undergraduate students completed direct and indirect measures of spider fear/avoidance, self-report questionnaires of psychopathology, an attentional bias task, and a proxy Behavioural Approach Task. TwoStep cluster analysis using implicit and explicit spider fear as criterion variables resulted in three clusters: (1) low explicit/low implicit; (2) average explicit/high implicit; and (3) high explicit/low implicit. Clusters with higher explicit fear demonstrated greater disgust propensity and sensitivity and less willingness to approach a spider. No differences between clusters emerged on anticipatory approach anxiety or attentional bias. We discuss results in terms of dual-systems and cognitive–behavioural models of fear.
Transcription activation at Class I CAP‐dependent promoters

Catabolite gene activator protein (CAP)‐dependent promoters can be grouped into three classes, based on the requirement for transcription activation and the position of the DNA site for CAP. Class I CAP‐dependent promoters require only CAP for transcription activation and have the DNA site for CAP located upstream of the DNA site for RNA polymerase. Amino acids 156 to 162 of the promoter‐proximal subunit of CAP are essential for transcription activation at Class I CAP‐dependent promoters, but are not essential for DNA binding, and are not essential for DNA bending. In the structure of the CAP‐DNA complex, these amino acids are located in a surface loop and form a cluster on the surface of the CAP‐DNA complex. Amino acids 261, 265, and 270 of the α subunit of RNA polymerase are essential for response to transcription activation by CAP at Class I CAP‐dependent promoters. Several lines of evidence indicate that transcription activation at Class I CAP‐dependent promoters requires a direct protein‐protein contact between amino acids 156 to 162 of the promoter‐proximal subunit of CAP and a molecule of RNA polymerase bound adjacent to CAP on the same face of the DNA helix. It is a strong possibility that this direct protein–protein contact involves amino acids 261 and 265 of the α subunit of RNA polymerase.
Hiding Relaxed Memory Consistency with a Compiler

We present a compiler technique, which is based on Shasha and Snir's delay set analysis, to hide the underlying relaxed memory consistency model for an optimizing compiler for explicitly parallel programs. The compiler presents programmers with a sequentially consistent view of the underlying machine, irrespective of whether it follows a sequentially consistent model or a relaxed model. To hide the underlying relaxed memory consistency model and to guarantee sequential consistency, our algorithm inserts fence instructions by identifying memory-barrier nodes. We reduce the number of fence instructions by exploiting the ordering constraints of the underlying memory consistency model and the property of fence and synchronization operations. We introduce dominators with respect to a node in a control flow graph to identify memory-barrier nodes and show that minimizing the number of memory-barrier nodes is NP-hard.
Nesterenkonia cremea sp. nov., a bacterium isolated from a soda lake.

A Gram-stain-positive, aerobic, non-motile, rod-shaped, non-endospore-forming bacterial strain, 10CT, was isolated from Lonar soda lake in India. Based on the 16S rRNA gene sequence analysis, this strain was identified as belonging to the genus Nesterenkonia and was most closely related to the type strains of Nesterenkonia lacusekhoensis (99.1 %, sequence similarity), Nesterenkonia aethiopica (96.9 %), Nesterenkonia flava (96.9 %) and related of the genus Nesterenkonia (<96.6 %, sequence similarity). However, the DNA-DNA relatedness of strain 10CT with N. lacusekhoensis KCTC 19283T was only 34.6±0.9. The DNA G+C content of strain 10CT was 68.6 mol%. Strain 10CT was an aerobic microbe with optimal growth at 37 °C, pH 7.5-8.0 and 5-6 % (w/v) NaCl. The cell-wall peptidoglycan of strain 10CT was of the type A4α (l-Lys-l-Glu). The major polar lipids present were phosphatidylglycerol, diphosphatidylglycerol and phosphatidylcholine. The major isoprenoid quinones were MK-7, MK-8 and MK-9. Major fatty acids of strain 10CT were anteiso-C15 : 0, anteiso-C17 : 0 and iso-C16 : 0. The results of phylogenetic, chemotaxonomic and biochemical tests allowed a clear differentiation of strain 10CT, which represents a novel member of the genus Nesterenkonia for which the name Nesterenkonia cremea sp. nov. is proposed. The type strain is 10CT (=LMG 29100T=KCTC 39636T=CGMCC 1.15388T).
Accuracy improvement of S-parameter method by modified open correction

Recently, S-parameter method that is the measurement method of the input impedance of the balanced antenna is proposed. It is a problem of this method that the jig influences measured value when the measurement frequency increases. To remove the influence of the jig, we have examined compensating method using the ABCD-matrix. In this report, to remove the influence of the jig, we propose a novel open correction compensating the influence of the impedance at the open end of the jig. The calculated result of the dipole antenna shows proposed method is very effective for improving the measurement accuracy.
An agent-based tutoring system for learning propositional logic using multiple linked representations

In this paper, we propose an agent-based ITS for learning propositional logic using two linked viewpoints and representations to address the problem on checking the validation of a given argument, articulating syntactic and semantic inference approaches. One motivation for this integration comes from the importance to involve students in two complementary viewpoints, permitting students to make connections between the two viewpoints involving different strategies, used in problem solving situations. Basically, the system works by placing students in a problem-solving situation and providing needed knowledge support based on his performance. We discuss the system and show its architecture and functionality, as well as its implementation details. Through scenarios with adequate coverage, we evaluate the value of the proposed approach and conclude that it is feasible and useful.
Least-squares methods for the extraction of surface currents from CODAR crossed-loop data: Application at ARSLOE

Least-squares methods are demonstrated that extract surface current radial velocities from first-order Coastal Ocean Dynamics Applications Radar (CODAR) sea-echo Doppler spectra for the compact crossed-loop/monopole antenna system. Based on the known physics of first-order sea scatter at HF, these techniques, implemented as software, are objective and automatic in that they: a) determine from the sea-echo phase and amplitude correction factors for the antenna elements; b) separate the first-order spectrum from the surrounding continuum for arbitrarily varying current conditions; c) using statistical hypothesis testing, select and use either a single or dual-angle model for radial current patterns, whichever best fits the data; d) calculate angles associated with given radial velocities; e) combine the data into a polar-coordinate map of radial velocity versus position; and f) calculate radial velocity uncertainties at each point on the map. In addition, as interpretive aids, two methods are evaluated and compared that provide total current vectors from single-site CODAR data, along with their uncertainties: model fitting and the application of the equation of continuity. It is shown how these methods can be applied to the older, CODAR 4-element antenna system, however, the following advantages of the crossed-loop/monopole system are discussed: it is physically more compact; analysis procedures are more efficient; resulting current velocities are more accurate, because there are no side-lobe problems; and finally, it also gives the ocean wave-height directional spectrum. These methods are tested and optimized against data taken during the Atlantic Remote Sensing Land Ocean Experiment (ARSLOE) storm (October 23-27, 1980), when surface currents varied in speed between 0-50 cm/s and over nearly 300° in angle. Current velocities were measured to a range of 36 km from the radar. Standard deviations in angle are typically 1°-3°; these translate to 2-3 cm/s rms radial velocity uncertainties over most of the coverage area, with decreased accuracy in angular sectors nearest the coast. Total current velocity vectors in strips parallel to shore obtained from model fitting have typical speed and angle uncertainties of 4 cm/s and 12°, respectively. Of the several formulations for the equation of continuity evaluated here, the best gave uncertainties of 5 cm/s, 12° at the closest range cells; these values increase rapidly with range to exceed 20 cm/s, 30° for distances greater than 20 km. The surface currents were observed to follow the wind throughout most of the storm at ARSLOE, but the current was almost always more closely parallel to the shore than the wind. An interesting exception occurred when the onshore storm wind that had prevailed for two days ceased; there was a rush of surface current directly offshore as the storm-surge sea level dropped. The surface current speed measured by CODAR in the upper meter of the ocean was, on the average, 2.1 percent of the windspeed.
Pruning Medial Axes

The medial axis is an attractive shape feature; however, its high sensitivity to boundary noise hinders its use in many applications. In order to overcome the sensitivity problem some regularization has to be performed. Pruning is a family of medial axis regularization processes, incorporated in most skeletonization and thinning algorithms. Pruning algorithms usually appear in a variety of application-dependent formulations. Inconsistent terminology used until now prevented analysis and comparison of the various pruning methods. Indeed many seemingly different algorithms are in fact equivalent. In this paper we suggest the rate pruning paradigm as a standard for pruning methods. The proposed paradigm is a framework in which it is easy to analyze, compare, and tailor new pruning methods. We analyze existing pruning methods, propose two new methods, and compare the methods via a model-based analysis. The theoretical analysis is supported by simulation results of the various pruning methods.
Development of cryogenically-cooled Yb : YLF chirped-pulse amplification laser for pumping few-cycle optical-parametric chirped-pulse amplification

As a pump source for intense few-cycle laser system with optical-parametric chirped-pulse amplification (OPCPA), we have been developing cryogenically-cooled Yb:YLF chirped-pulse amplification laser. So far we have successfully obtained high energy output pulse with 107 mJ of energy from a single-stage regenerative amplifier, which can be compressed to 2.2 ps in duration without pedestal. An adaptive phase control of laser pulse is underway for indirect dispersion compensation of generated idler pulse on OPCPA.