Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular Characterization of Human Papillomaviruses Associated with Cervical Cancer in Brazzaville, Congo

Knowledge of the viral ecology of human papillomaviruses is essential in the prevention of cervical cancer. This work aimed to identify human papillomavirus genotypes associated with cervical cancers in the capital city of Brazzaville. 66 paraffin blocks of cervical biopsies were collected between 2016-2017. After extraction of viral DNA, amplification and genotyping was performed using Gene Xpert technology from the Xpert HPV kit. The mean age was 54.48 ± 16.98 years (range 18-88 years). HPV viral DNA was identified in all samples analyzed, giving a prevalence of 100%. The most frequent genotype was HPV-16 (80.3%). Six percent of the patients were carriers of the HPV-18/45 combination and 12.1% of other HPV-HR genotypes. HPV-16/HPV-18/45 co-infection was observed in 1.5% of cases. According to the type of cancer induced, HPV-16 was found in 83.3% of squamous cell carcinomas and 50% of adenocarcinomas. In this work, the authors observed a very high frequency of HPV-16 whatever the type of cancer in Brazzaville.
The Interaction between Human Papillomavirus Type 16 and FADD Is Mediated by a Novel E6 Binding Domain (cid:1)

High-risk strains of human papillomavirus, such as types 16 and 18, have been etiologically linked to cervical cancer. Most cervical cancer tissues are positive for both the E6 and E7 oncoproteins, since it is their cooperation that results in successful transformation and immortalization of infected cells. We have reported that E6 binds to tumor necrosis factor receptor 1 and to Fas-associated death domain (FADD) and, in doing so, prevents E6-expressing cells from responding to apoptotic stimuli. The binding site of E6 to FADD localizes to the ﬁrst 23 amino acids of FADD and has now been further characterized by the use of deletion and site-directed mutants of FADD in pull-down and functional assays. The results from these experiments revealed that mutations of serine 16, serine 18, and leucine 20 obstruct FADD binding to E6, suggesting that these residues are part of the E6 binding domain on FADD. Because FADD does not contain the two previously identiﬁed E6 binding motifs, the Lxx (cid:1) Lsh motif, and the PDZ motif, a novel binding domain for E6 has been identiﬁed on FADD. Furthermore, peptides that correspond to this region can block E6/FADD binding in vitro and can resensitize E6-expressing cells to apoptotic stimuli in vivo. These results demonstrate the existence of a novel E6 binding domain. cloned in-frame with the activation domain of the plasmid. To express FADD and its variants in the pBD plasmid (Strat- agene) for use in the mammalian two-hybrid assay, the appropriate region of FADD was cloned in-frame with the binding domain of the pBD plasmid. To express FADD and its variants in the Escherichia coli system for subsequent protein puriﬁcation, the EcoRI-XhoI fragment from pM-FADD, coding for FADD, was cloned in-frame with the His 6 epitope of pTriEx-4 (Novagen) by using the SmaI-XhoI sites in the multiple cloning site to produce the plasmid pHis-FADD. Production of the D1 construct (lacking amino acids 23 to 62) and the D2 construct amino acids 79) been previously The point mutations in the SELT, SSLS, SLT2, SLT3, and SLT4 constructs were based on by using a QuikChange site-directed mutagenesis kit (Stratagene) according to the manufacturer’s protocol. The primer
Research Study of Business Cycle and Early Warning Indicators for the Economy of Hong Kong – Challenges of Forecasting Work amid the COVID-19 Pandemic

Timely indication of current and near-term economic situation is important. In particular, early warning signal ahead of economic downturn / crisis is vital for policy makers to prepare timely responses. The Organisation for Economic Cooperation and Development (OECD) has developed a system of leading indicators called Composite Leading Indicators (CLIs) for business cycle analysis and to provide effective and accurate early warning signal. CLI is an aggregate time series which aims to show a leading relationship with the growth cycles of key macro-economic indicators such as Gross Domestic Product (GDP). It is calculated by combining component series which cover a wide range of short-term indicators, such as opinions about economic activity, housing permits, financial and monetary data, etc. This paper discusses the methods to effectively identify early warning indicators and build up a CLI on economic growth of Hong Kong based on the OECD’s framework and simple forecasting model through the Vector Autoregressive model (VAR). In particular, the COVID-19 pandemic has caused serious disruptions to economic activities, both locally and globally. Further studies have recently been attempted to assess the performance of the CLI and short-term forecast, which were built on pre-COVID-19 parameters, under such abrupt economic situations and identify further adjustments to e nhance the forecasting models.
Population-based Cancer Screening

K E Y W O R D S Breast cancer Cancer screening Care quality Colorectal cancer Indicators Nurse Background: European guidelines for the quality of screening programs for breast and colorectal cancer describe process, structure, and outcome indicators. However, none of them specifically evaluate coordination and continuity of care during the cancer screening process. Objectives: The aim of this study was to identify and adapt care quality indicators related to the coordination and continuity of the cancer screening process to assess nursing care in cancer screening programs. Methods: The indicators proposed in this study were selected in 2 phases. The first consisted of a literature review, and the second was made by consensus of an expert group. An electronic literature search was conducted, through June 2016. From a total of 225 articles retrieved, 14 studies met inclusion criteria, and these 14 documents were delivered to the group of experts for evaluation and to propose a final list of agreed-upon indicators. Results: The group of experts selected 7 indicators: adequacy and waiting time derivation of participants, delivery and availability of the report of the process, understanding professionals involved in the process, and satisfaction and understanding of participants. Conclusions: These indicators should help identify areas for improvement and measure the outcome of coordination and continuity of care. Implications for Practice: The results provided a common set of indicators to evaluate the coordination and continuity of care for cancer screening and to
예측제어의 마이크로콘트롤러 구현을 위한 QP 해법과 그 적용방법

In this paper, we propose a method by which QP (Quadratic Programming) problems can be solved in realtime so that we can implement the predictive control algorithm on a microcontroller system. Firstly, we derive a solution to QP problems by converting the original QP problems to its equivalent least squares with inequalities. Secondly, we propose a predictive control algorithm that can give good realtime computation performance by utilizing the fact that some parameters needed for solving QP problems can be computed offline. Finally, we illustrate that the proposed method can give good realtime features by running the C-code application constructed using the proposed method on a microncontroller system.
A Study in Contradiction: Data and Annotation for AIDA Focusing on Informational Conflict in Russia-Ukraine Relations

This paper describes data resources created for Phase 1 of the DARPA Active Interpretation of Disparate Alternatives (AIDA) program, which aims to develop language technology that can help humans manage large volumes of sometimes conflicting information to develop a comprehensive understanding of events around the world, even when such events are described in multiple media and languages. Especially important is the need for the technology to be capable of building multiple hypotheses to account for alternative interpretations of data imbued with informational conflict. The corpus described here is designed to support these goals. It focuses on the domain of Russia-Ukraine relations and contains multimedia source data in English, Russian and Ukrainian, annotated to support development and evaluation of systems that perform extraction of entities, events, and relations from individual multimedia documents, aggregate the information across documents and languages, and produce multiple “hypotheses” about what has happened. This paper describes source data collection, annotation, and assessment.
Role of Bcl-2 in αβ T Cell Development in Mice Deficient in the Common Cytokine Receptor γ-Chain: The Requirement for Bcl-2 Differs Depending on the TCR/MHC Affinity

Mice lacking the common cytokine receptor γ-chain (γc) exhibit severely compromised T cell development, with diminished Bcl-2 expression in mature (CD4+ or CD8+) thymocytes and peripheral T cells. Enforced expression of Bcl-2 in these mice partially rescued αβ T cell development but not γδ T cell development. Transgenic expression of the OVA-specific DO11.10 (DO10) TCR also could modestly increase thymocyte numbers, and T cells expressing the transgenic TCR (KJ1-26+ T cells) were found in the periphery. Interestingly, the presence of KJ1-26+ T cells was dependent on the MHC background and was seen in the moderate affinity H-2d/d background but not in the higher affinity H-2d/b background in γc-deficient mice. In contrast, KJ1-26+ T cells exist in the periphery in both the H-2d/d and H-2d/b backgrounds in DO10 transgenic γc wild-type mice. These results suggest that the importance of γc-dependent signals for T cell development differs depending on the affinity of TCR for MHC. Moreover, enforced expression of Bcl-2 had a much greater effect on the development of γc-deficient T cells expressing the DO10 TCR in the high affinity H-2d/b background than in the H-2d/d background, suggesting that γc-dependent Bcl-2 expression influences T cell development in a TCR/MHC-dependent manner.
PREVALENCE OF INTESTINAL WORMS AMONG SCHOOL CHILDREN IN CHAD: IMPORTANCE OF HIGHLIGHTING THE CONCENTRATION METHOD IN FECAL EXAMINATION

A third party of humanity is infested by intestinal worms. Although not always easy to discover the impact on health of parasitism by intestinal worms is admitted all the same. In Chadian medical analysis laboratory, the analysis limit to a direct coprological examination. This work aims to establish the prevalence rates of the intestinal parasites from three technics of parasitic coprology, to improve the diagnosis in our analysis laboratories and insure better medicinal prescriptions in our hospitals. The present study took place in Sahelian (Abéché, Bokoro and N’Djamena) and Sudanese (Bongor, Pala, Torrok and Lai) zones. Every stool was submitted to a direct macroscopic examination and two technics of concentration. All eight species of Helminthes ( Hymenolepis nana, Taenia saginata, Taenia solium, Ascaris lumbricoides, Ancylostoma spp., Trichuris trichiura, Strongyloides stercoralis and Schistosoma mansoni ) were found during this investigation. The global rates of infection, that is by at least a species of parasite different and equal were in 36.1% for MOD, 51.1% for MFE and 55.2% for MKA. The number of cases of infections mono-, bi- and tri specific revealed in this work was 362 by the MOD, 512 by the MFE and 554 by MKA. Since prevalence’s and number of very high parasitic types of associations observed by the methods of concentration in this study, it would be necessary to incite laboratories of medical analyses of hospitals in Chad to use technics of concentration for the improvement of coprological diagnosis.
FAM123A Binds Microtubules and Inhibits the Guanine Nucleotide Exchange Factor ARHGEF2 to Decrease Actomyosin Contractility*** in a plus-end direction. Domain interaction experiments

The FAM123 gene family comprises three members, FAM123A, the tumor suppressor WTX(FAM123B) and FAM123C. WTX is required for normal development and causally contributes to human disease, in part through its regulation of β -catenin-dependent WNT signaling. The roles of FAM123A and FAM123C in signaling, cell behavior and human disease remain less understood. We defined and compared the protein-protein interaction networks for each member of the FAM123 family by affinity purification and mass spectrometry. Protein localization and functional studies suggest that the FAM123 family members have conserved and divergent cellular roles. In contrast to WTX and FAM123C, we found that microtubule-associated proteins were enriched in the FAM123A protein interaction network. FAM123A interacted with and tracked dynamic microtubules revealed a ‘SKIP’ amino acid motif in FAM123A that mediated interaction with the microtubule tip tracking proteins EB1 and EB3, and therefore with microtubules. Cells depleted of FAM123A showed compartment-specific effects on microtubule dynamics, increased actomyosin contractility, larger focal adhesions and decreased cell migration. These effects required binding of FAM123A to and inhibition of the guanine nucleotide exchange factor ARHGEF2, a microtubule-associated activator of RhoA. Together, these data suggest that the ‘family-unique’ SKIP motif enables FAM123A to bind EB proteins, localize to microtubules and coordinate microtubule dynamics and actomyosin contractility.
KNOWLEDGE, ATTITUDE AND PRACTICES OF ORAL HEALTH CARE OF CHILDREN RESIDING IN ORPHANAGES OF UDAIPUR CITY

orphans, oral ABSTRACT Oral health is an integral component of general health which has great impact on quality of life. Groups of people such as disadvantaged children are often denied access to health information and knowledge due to a number of reasons for example inaccessibility, nature of the disadvantage that may necessitate participation of specialized professionals. The sudy was undertaken to assess the knowledge attitude and practices of orphan children. A cross-sectional survey was conducted among 600 children aged 5, 12 and 15 years living in different orphanage houses of Udaipur city. The WHO self assessment questionnaire including 14 items with closed-ended questions was distributed. 7 The questionnaire was meant to assess the sources of information on oral health knowledge, attitude, and practice of children living in the orphanages. The data obtained was statistically analysed and the result showed that oral health knowledge and practices were not satisfactory. The self perception of the study sample did not match with the knowledge, attitude and practices of the same. The absence of parents or caregivers does have a considerable effect on the oral health attitude of the child.
Effects of organic compounds on micropropagation of strawberry ‘Pharachatan 80’

This approach was conducted in order to optimize growth and multiplication of micropropagated strawberry ‘Pharachatan 80’. A response surface methodology (RSM) was applied to test the Linsmaier and Skoog (LS) organic compounds (comprising of nicotinic acid, pyridoxine, thiamine, glycine, myo-inositol) and adenine sulfate. It was found that individual components of organic compounds in Linsmaier and Skoog (LS) had no signi ﬁ cant effects on plant growth and multiplication. However, optimization of individual components as new formulations and adjustment of LS as relative concentrations showed that these adjusted optimized formulations can improve shoot growth and multiplication in strawberry ‘Pharachatan 80’.
Optimization of pain management in cervical dystonia

Cervical dystonia (CD) is the the applying of the invasive or non-invasive brain stimulation methods. However, due to the lack of evidences from the large, randomized, controlled, clinical trials, an issuance of unambiguous recommendations remains difficult. Further studies on a poor response to BoNT injections and analgesic effects of above methods in the treatment of the CD-related pain are needed.
Human Papillomavirus Genotype and Oropharynx Cancer Survivalin the United States 2

53 Background. The presence of human papillomavirus (HPV) DNA in oropharyngeal 54 squamous cell cancer (OPSCC) tissue appears to be a strong predictor of improved 55 prognosis, but this observation has not been explored in a population-based sample 56 with generalizable findings. 57 Methods . Follow-up data from a large sample of OPSCC patients identified through six 58 population-based cancer registries in the US was used to characterize the association 59 of tumor HPV status with survival. 60 Results. HPV DNA was detected in tumor tissue from 71% (378/529) of the OPSCC 61 patients. A total of 65% of patients with HPV16-associated tumors survived 5-years 62 compared to 46% of patients with other HPV-types and 28% of patients with HPV- 63 negative tumors (p log-rank test <0.0001). The OPSCC patients with detectable HPV16 64 DNA had a 62% reduced hazard of death at 5-years, and patients with other HPV types 65 had a 42% reduced hazard of death at 5-years compared to HPV-negative patients. Compared to non-Hispanic Whites, Blacks with OPSCC had a 2.5-fold greater risk of 67 death at 5-years after adjustment for HPV-status and other prognostic variables. Both surgery and radiation therapy were associated with a reduced 5-year risk of death, but no evidence was an interaction between radiotherapy or surgery on survival time.
AN INSIGHT INTO PROSTHETIC COMPOSITES

Tooth-colored composite resin fillings are becoming very popular now a days for cavity fillings. It is limited for small cavities in posterior teeth. Besides its wide use and popularity, it has scope for improvement due to polymerization shrinkage and its lifespan. These are problems that may be addressed by using an alternative indirect fabrication and placement restorative procedure. Indirect composites offer an esthetic alternative or supplement to ceramics for posterior teeth in certain clinical situations.
Effects of Estradici on Prolactin and Growth Hormone Messenger RNAs in Cultured Normal and Neoplastic (MtT/W15 and GH3) Rat Pituitary Cells1

The effects of 17/9-estradiol (E17/3) on prolactin (PRL) cell prolifera tion and on the expression of PRL and growth hormone (GH) proteins and mRNAs were analyzed in cultured pituitary cells by immunocytochemistry, in situ hybridization, and Northern blot hybridization studies. Three different cell cultures were used: (a) normal pituitary cells; (b) GH3 tumor cell line; and (c) MtT/W 15. a transplantable PRL and (.II-producing pituitary tumor. E170 (10~7M) caused a significant increase in PRL cell proliferation in normal pituitary [3.9 Â±0.4 versus 7.7 Â±0.9% (SEM) of immunostained PRL cells with thymidine incorporation] |/' < 0.01) but produced a significant decrease in PRL cell proliferation in MtT/W15 primary cell cultures (6.7 Â±1.0 versus 3.7 Â±0.8%) \P < 0.05). PRL mRNA was significantly increased in normal pituitary and in <. ll< tumor cells by El 7/3treatment. There was a significant decrease in PRL mRNA and an increase in GH mRNA expression in cultured MtT/W 15 tumor cells by immunocytochemistry and in situ hybridization analyses. The percentage of cells producing both PRL and GH or mammosomatotropic cells analyzed by two different techniques declined after one week in culture in normal pituitary cells and in cultured Mil/ W15 tumor cells after E170 treatment. These results show that E17/3 has a direct stimulatory effect on normal pituitary and Gil, cells and a direct inhibitory effect on MtT/W15 tumor cells with respect to cell proliferation and PRL hormone and mRNA expression.
Image Deblurring Using Adaptive Sparse Domain Selection and Adaptive Regularization

: Problem Statement: Image restoration (IR) aims to reconstruct a high-quality image from its degraded measurement. Approach: As a powerful statistical image modeling technique, sparse representation has been successfully used in various image restoration applications. The contents of images can vary significantly across different images or different patches in a single image, and then, for each selected patch, one set of bases are adaptively selected to characterize the local sparse domain. Then two adaptive regularization terms are used into the sparse representation framework. First, a set of autoregressive (AR) models are adaptively selected to regularize the image local structures. Second, the image non-local self-similarity is introduced as another regularization term estimated for better image restoration performance. Conclusion: Iterative experiments using adaptive sparse domain selection and adaptive regularization, the proposed method achieves much better results than many state-of-the-art algorithms in terms of both PSNR and visual perception.
Comparison of Different Machine Learning Algorithms for Action Recognition

With the increasing rate robots take part in our private and business life, the complexity of the tasks they perform will grow. If cleaning up the table at home or co-working in a factory, one of the easiest ways for robots to acquire the knowledge for performing these new tasks is by learning from multiple examples. Therefore, robots have to be able to correctly recognize and mimic human actions derived from sensor data. To achieve this, supervised machine learning models are trained on recorded datasets from the domain of human action recognition. The available datasets often have small numbers of training sequences, which often results in model overfitting and poor generalization performance. Low classification accuracy due to lack of training data creates a significant challenge. Diverse augmentation techniques can improve the training results by artificially enhancing small datasets. This thesis presents and compares different machine learning approaches for human action recognition using tracked skeletal data. The focus is on how different data augmentation techniques can facilitate recognition accuracy. For the performance measurement of each augmentation technique three machine learning models have been selected a baseline convolutional neural network, a simple recurrent neural network and an improved hybrid one, a combination of the aforementioned. The implemented augmentation techniques for human skeleton joint coordinates are scale, shift, noise, subsample and interpolation. The models have been trained on three publicly available benchmark datasets. The relative improvement per augmentation type has been derived from the experimental results. The evaluation of the results reveals that the shift augmentation has the strongest impact on all models, followed by the scale augmentation. The recurrent model displays the largest capacity for augmentation enhancements. The hybrid model achieves the highest absolute accuracy and is less affected by the applied augmentations.
A Review of Hydroflorocarbons (HFC’S) Refrigerants as an Alternative to R134a Refrigerant

The 80% Indians domestic refrigerators use R134a as refrigerant due to its excellent thermodynamic and thermo physical properties. However, because of higher GWP (1300) its impact on environment is dangerous. Due to such hazardous impact, it is necessary to find out an alternative refrigerant for R134a without affecting performance of vapor compression system. This paper investigate performance of vapor compression refrigeration system with alternative eco-friendly refrigerants such as R32, R134a, R152a, R290, R1270, R600a, RE170, R290.Vapor compression system work on four processes compression, evaporation, expansion and condensation. During analysis, various parameters like evaporating pressure, pressure ratio, and power per ton of refrigeration, volumetric cooling capacity, compression work and coefficient of performance are considered. R152a and RE170 are better alternative refrigerants to R134a. These refrigerants shows 4.65% and 6.27% more COP than that of conventional R134a refrigerant respectively .