Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence and correlates of psychological stress among teachers at a national key comprehensive university in China

ABSTRACT The present study investigated the levels of stress and associated factors in university teachers to provide a foundation for exploring strategies for preventing teacher stress. We conducted a cross-sectional survey using a composite questionnaire with the 10-item Kessler Psychological Distress Scale (K10) as the core at a comprehensive university located in northeast China. The number of effective respondents was 603. The average K10 score was 22.87 ± 8.18, and the positive rate (K10 > 21) was 54.06%. University teachers generally experienced high stress levels. The highest stress levels were observed in teachers whose academic title was lecturer or associate professor, according to a comprehensive consideration of several factors, including age, income, and teaching tenure. Teachers of engineering and agriculture and forestry have lower stress levels than teachers of other subjects. A lack of research funding and lack of routine rest on the weekends or on statutory holidays may increase teachers’ stress, whereas regular exercise may reduce stress. Academic title promotion, scientific research pressure, and lack of routine breaks and physical exercise were the main sources of stress.
Experimental Characterization of a Microchannel Heat Sink Made by Additive Manufacturing

Microchannel heat sinks allow removal of dense heat loads from high-power electronic devices at modest chip temperature rises. Such heat sinks are produced primarily using conventional subtractive machining techniques or anisotropic chemical etching, which restricts the geometric features that can be produced. Owing to their layer-by-layer and direct-write approaches, additive manufacturing (AM) technologies enable more design-driven fabrication and offer improved geometric freedom and complexity. There has been limited assessment of the capability of AM process to produce microchannel heat sinks that meet nominal geometry and performance targets, even for conventional designs. Direct metal laser sintering (DMLS) was used to demonstrate additive manufacture of an aluminum alloy (AlSi10Mg) microchannel heat sink with straight, parallel channels (DH = 500 μm). The thermal and hydraulic performance of the heat sink was characterized over a range of mass fluxes from 500 kg/m2s to 2000 kg/m2s using water as the working fluid. The straight microchannel design allows these experimental results to be directly compared against established predictions from the literature. The comparison facilitates an assessment of the role of geometric or property differences introduced by the AM process (relative to conventional fabrication approaches) in realizing the nominal design. The insights gained from this evaluation, which offers an improved description of the fabrication constraints and sets expectations on fidelity to the design targets, will be used in ongoing work that explores heat sink designs exploiting the full range of geometric complexity made possible with additive manufacturing.
Orchestration of End-to-End Network Services in the 5G-Crosshaul Multi-Domain Multi-Technology Transport Network

Upcoming 5G mobile networks are addressing ambitious KPIs not just in terms of capacity and latency, but also in terms of network control and management. In this direction, network management schemes need to evolve to provide the required flexibility, and automated and integrated management of 5G networks. This also applies to the 5G-Crosshaul transport network, which provides an integrated fronthaul and backhaul. Software defined networking and NFV are seen as key enablers for that. This article validates the flexibility, scalability, and recovery capabilities of the 5G-Crosshaul architecture in a testbed distributed geographically. More specifically, the central component of the validation is the hierarchical 5G-XCI, conceived to handle multi-domain multi-technology transport network resources. Its performance is characterized through two experimental case studies. The first one illustrates the automated provisioning of all network resources required to deploy a complete LTE virtual mobile network featuring fronthaul and backhaul configurations. This takes 10.467 s on average for the network under test. The second one exploits the flexibility of the hierarchical XCI to apply local or centralized service recovery in the event of link failure depending on the desired path optimality vs. recovery time trade-off. On average, recovery takes 0.299 s and 6.652 s, respectively. Overall, the proposed solution contributes to attaining the target set for 5G networks of reducing service setup from hours to minutes.
Cell tracking in vitro reveals that the extracellular matrix glycoprotein Tenascin-C modulates cell cycle length and differentiation in neural stem/progenitor cells of the developing mouse spinal cord

ABSTRACT Generation of astrocytes during the development of the mammalian spinal cord is poorly understood. Previously, we have shown that the glycoprotein of the extracellular matrix (ECM) tenascin-C (Tnc) modulates the expression territories of the patterning genes Nkx6.1 and Nkx2.2 in the developing ventral spinal cord, tunes the responsiveness of neural stem/progenitor cells towards the cytokines FGF2 and EGF and thereby promotes astrocyte maturation. In order to obtain further mechanistic insight into these processes, we have compared embryonic day-15 spinal cord neural progenitor cells (NPCs) from wild-type and Tnc knockout mice using continuous single-cell live imaging and cell lineage analysis in vitro. Tnc knockout cells displayed a significantly reduced rate of cell division both in response to FGF2 and EGF. When individual clones of dividing cells were investigated with regard to their cell lineage trees using the tTt tracking software, it appeared that the cell cycle length in response to growth factors was reduced in the knockout. Furthermore, when Tnc knockout NPCs were induced to differentiate by the removal of FGF2 and EGF glial differentiation was enhanced. We conclude that the constituent of the stem cell niche Tnc contributes to preserve stemness of NPCs. Summary: We have shown, using digital video microscopy based cell lineage tracing, that the glycoprotein of the extracellular matrix tenascin-C modulates growth factor responsiveness and cell cycle length of embryonic spinal cord progenitor cells in vitro.
How to Use Blockchain for Diabetes Health Care Data and Access Management: An Operational Concept

Introduction: Patients with diabetes often generate large amounts of data specifically related to the disease and to their general health. Cross-institutional sharing of patient health care data is complex, and as a consequence, data are not always available to the health care provider treating the patient. Accommodating this challenge could lead to better clinical effectiveness and improve clinical research. This work aims to present an approach for a blockchain-based platform for sharing health care data. The approach considers privacy concerns, data sharing, and patients as the center for governing their own data. Methods: The concept of this blockchain-based platform consists of using the NEM multi-signature blockchain contracts for access control of data management and the sharing and encryption of data to allow privacy and control of health care data. The architecture is built around cryptography, tokens, and multi-signature contracts. The multi-signature contract enables several entities to administrate the activity of an account and control the assets of one account. Multi-signature generates a contract that assigns the rights and powers of a certain account to other accounts; this contract can be edited to allow or remove entities. Discussion: Using blockchain could lead to improvements in diabetes data management. In the coming years, this technology should be implemented in existing small-scale diabetes health care system to explore its real-world benefits and challenges. Conclusion: This new approach could potentially lead to more efficient sharing of data between institutions and utilization of new types of data and research possibilities.
Atypical Facial Clefts From Northcentral Nigeria, Review of 36 Cases

Objective: This study aims to present the pattern and management of atypical facial clefts from a Nigerian population. Design: This is a retrospective study of patients seen during series of surgical outreach programs in North Central Nigeria, between 2011 and 2017. All cases of atypical facial clefts encountered were evaluated for the pattern of presentation using Tessier classification system. All of them were surgically repaired and outcome was determined using a Likert scale. Data were presented using descriptive statistics. Setting: Outreach programs in North Central Nigeria by Cleft & Facial Deformity Foundation. Results: Thirty-six patients, 19 (52.8%) males and 17 (47.2%) females, were studied. The age range was 1 week to 34 years, with mean (standard deviation) of 11.2 (11.8) years. Fifty-eight cleft cases were recorded, with Tessier 1 being the commonest (n = 14; 24.1%) cleft type. There were 35 (60.3%) cases of middle cleft, 14 (24.2%) cases of oblique cleft, and 9 (15.5%) cases of lateral cleft. Typical cleft lip and palate coexisted with atypical facial cleft in 2 (5.6%) patients. Cleft was found to be median in 12 (33.3%) patients and right sided in 9 (25%) patients. Majority (n = 24, 66.7%) of the cases were repaired by simple excision plus direct closure with successful outcome. Conclusions: Numerical classification by Paul Tessier has reduced the inconsistencies of nomenclature among practitioners. Majority of atypical facial clefts could be treated by simple techniques with satisfactory outcomes. However, the more complex cases will require multistaged surgical approach.
Short Communication: Bioequivalence of Tenofovir and Emtricitabine After Coencapsulation with the Proteus Ingestible Sensor.

Adherence to tenofovir disoproxil fumarate/emtricitabine (TDF/FTC, Truvada®) is the primary determinant of HIV pre-exposure prophylaxis (PrEP) efficacy. Despite its importance, limitations exist in current methods of adherence quantification, restricting their implementation in the clinic. Proteus Discover (Proteus Digital Health®) can measure the time of each dose using an ingestible sensor that is coencapsulated with medication. In this study, the bioequivalence of coencapsulated TDF/FTC with the Proteus sensor was compared relative to unencapsulated drug. This was a 1:1 randomized cross-over study in which healthy participants received a single dose of unencapsulated and coencapsulated TDF/FTC. A 14-day washout separated each period. Blood was collected at predose and at 0.25, 0.5, 1, 2, 4, 6, 10, 24, 48, and 72 h postdose. Plasma concentrations were determined by LC-MS/MS methods, with a 10 ng/mL lower limit of quantitation (LLOQ) for both tenofovir (TFV) and FTC. Noncompartmental analysis was carried out with Phoenix® WinNonlin® for maximum concentrations (Cmax), area under the concentration-time curve from time 0 to the last measured time point (AUClast) and AUC extrapolated to infinity (AUCinf). Geometric mean ratios were calculated for each parameter and bioequivalence was defined as the 90% confidence interval (CI) of each ratio being within 80%-125%. Twenty-four participants (11 males; 19 white, 3 African American, and 2 Hispanic) completed both visits. Mean ± SD age was 28 ± 4 years and weight was 74 ± 14 kg. The 90% CIs for TFV Cmax, AUClast, and AUCinf were 89%-119%, 94%-111%, and 96%-111%, respectively. The 90% CIs for FTC Cmax, AUClast, and AUCinf were 96%-120%, 96%-108%, and 96%-108%, respectively. Bioequivalence was observed for the coencapsulation of TDF/FTC with the Proteus ingestible sensor, as assessed by a rigorously conducted pharmacokinetic study. Future studies will evaluate the utility and effectiveness of the sensor system as a tool to monitor PrEP adherence in clinical settings.
Abundance, rather than composition, of methane‐cycling microbes mainly affects methane emissions from different vegetation soils in the Zoige alpine wetland

Methane fluxes, which are controlled by methanogens and methanotrophs, vary among wetland vegetation species. In this study, we investigated belowground methanogens and methanotrophs in two soils under two different dominant vegetation species with different methane fluxes in the Zoige wetland, which was slightly but significantly (p ≤ 0.05) higher in soils covered by Carex muliensis than that in soils covered by Eleocharis valleculosa. Real‐time quantitative PCR and Illumina MiSeq sequencing methods were used to elucidate the microbial communities based on the key genes involved in methane production and oxidation. The absolute abundances of methanogens and methanotrophs of samples from C. muliensis were 1.80 ± 0.07 × 106 and 4.03 ± 0.28 × 106 copies g‐soil−1, respectively, and which from E. valleculosa were 3.99 ± 0.19 × 105 and 2.53 ± 0.22 × 106 copies g‐soil−1 , respectively. The t‐test result showed that both the abundance of methanogens and methanotrophs from C. muliensis were significantly higher (p ≤ 0.05) than that of samples from E. valleculosa. However, the diversities and compositions of both methanogens and methanotrophs showed no significant differences (p ≥ 0.05) between vegetation species. The path analysis showed that the microbial abundance had a greater effect than the microbial diversity on methane production potentials and the regression analysis also showed that the methane emissions significantly (p ≤ 0.05) varied with the abundance of methane‐cycling microbes. These findings imply that abundance rather than diversity and composition of a methane‐cycling microbial community is the major contributor to the variations in methane emissions between vegetation types in the Zoige wetland.
Early detection of peripheral neuropathy using stimulated skin wrinkling test in human immunodeficiency virus infected patients

Abstract Peripheral neuropathy is a common condition of human immunodeficiency virus (HIV)-infected patients, which often remains undetected. We assessed the performance of stimulated skin wrinkling-eutectic mixture of local anesthetic (SSW-EMLA) test compared with brief peripheral neuropathy screening (BPNS) to detect HIV neuropathy. This is a cross-sectional study conducted in HIV-positive patients. A modified skin wrinkling grading was used to assess SSW-EMLA effect. BPNS-detectable neuropathy was assessed by a combination of neuropathy severity scoring scale (subjective) and objective method of sensory and tendon reflex examination. The SSW-EMLA test accuracy with reference to BPNS was assessed using sensitivity and specificity and predictive values. In a total of 99 HIV patients, 61.6% were males and the majority age group were between 30 and 40 years (52%). The neuropathy detection was SSW-EMLA test 36.4% versus BPNS 15.2% (P = .04). The sensitivity of SSW-EMLA test was 60.0% [95% confidence interval (95% CI) 34.5–81.7], specificity 67% (95% CI 63.3–3–71.7), and overall accuracy of 66.7% (95% CI 58.9–73.2). The SSW-EMLA test detected many more peripheral neuropathy cases than BPNS in HIV patients and has potential as an alternative test for screening for HIV neuropathy in resource-constraint hospitals in Indonesia.
Improved Adaptive Brovey as a New Method for Image Fusion

An ideal fusion method preserves the Spectral information in fused image and adds spatial information to it with no spectral distortion. Among the existing fusion algorithms, the contourlet-based fusion method is the most frequently discussed one in recent publications, because the contourlet has the ability to capture and link the point of discontinuities to form a linear structure. The Brovey is a popular pan-sharpening method owing to its efficiency and high spatial resolution. This method can be explained by mathematical model of optical remote sensing sensors. This study presents a new fusion approach that integrates the advantages of both the Brovey and the cotourlet techniques to reduce the color distortion of fusion results. Visual and statistical analyzes show that the proposed algorithm clearly improves the merging quality in terms of: correlation coefficient, ERGAS, UIQI, and Q4; compared to fusion methods including IHS, PCA, Adaptive IHS, and Improved Adaptive PCA.
Using Activity Tracker Data for the Assessment of Physical Activity in Public Health Studies

Activity trackers are not just popular for personal wellbeing, but are also used more and more for assessing physical activity in public health studies. However, they provide data that is much richer than that from pedometers, and different from that of lab equipment. Using activity tracker data for the assessment of physical activity therefore requires different methods to address properties, limitations, and new opportunities arising from these devices. We suggest a set of measures that can be applied to a study population's activity tracker data and that give insights into compliance, distribution and intensity of physical activity, and sedentary behavior. We conclude that activity trackers are a powerful tool that can provide rich insights for the assessment of physical activity in public health studies.
A K-band series-fed microstip array antenna with low sidelobe for anticollision radar application

A k-band microstrip array antenna with low sidelobe is proposed in this letter. The antenna array is designed for anticollision radar application. It is a planar series-fed antenna array which consists of eight identical linear series-fed arrays with low sidelobe. The linear series-fed arrays are fed by a microstrip line with impedance matching stubs. The characteristic of low sidelobe can be realized by changing the width of the antenna units and the impedance matching stubs. The shorted holes at both ends of the linear arrays are used to enhance the performance of the antenna array in both impedance matching and radiation pattern. The antenna array is simulated, manufactured, and measured. The measurement results agree with the simulation results. The experiment results demonstrate that the voltage standing wave ratio (VSWR) of the antenna is less than 2 in the working frequency band (24.3–24.7 GHz). The sidelobe levels in both E-plane and H-plane of the antenna are less than −23 dB and good cross polarization is also obtained in the working frequency band.
M3RNA Drives Targeted Gene Delivery in Acute Myocardial Infarction.

IMPACT STATEMENT The M3RNA (microencapsulated modified messenger RNA) platform is an approach to deliver messenger RNA (mRNA) in vivo, achieving a nonintegrating and viral-free approach to gene therapy. This technology was, in this study, tested for its utility in the myocardium, providing a unique avenue for targeted gene delivery into the freshly infarcted myocardial tissue. This study provides the evidentiary basis for the use of M3RNA in the heart through depiction of its performance in cultured cells, healthy rodent myocardium, and acutely injured porcine hearts. By testing the technology in large animal models of infarction, compatibility of M3RNA with current coronary intervention procedures was verified.
Psychological health and resilience: the impact of significant earthquake events on tertiary level professional students. A cross-sectional study

Background: The effect of natural disasters internationally is linked to intensity and duration and the impact of these events for tertiary level professional students is not clearly understood. Following a 7.1 magnitude earthquake in New Zealand in 2010 (with aftershocks lasting 27 months) a number of tertiary nursing students experienced significant disruption to their studies. Aim: To compare the psychological health, resilience and the impact on learning for three cohorts of students engaged in tertiary nursing education during this time. Method: A cross-sectional survey design and convenience sampling was used for three cohorts of learners. An online survey was completed (n = 290) and included: Depression Anxiety and Stress Scale; PTSD Checklist; Work and Social Adjustment Scale; Connor-Davidson Resilience Scale. Results: Statistically significant differences were found across the psychometric scales with regard to relationship status. Whilst an increase in self-reported physical and mental health issues prior to and following the earthquakes were noted, mitigating factors were also identified. Conclusions: In order to support psychological health amongst nursing students, tertiary education systems need to plan for sustainable learning. The importance of facilitating future orientation within organisations is necessary to develop resilience amongst staff and students, which, in turn, will enable on-going education during significant disaster events.
How Endogenous Crowd Formation Undermines the Wisdom of the Crowd in Online Ratings

People frequently consult average ratings on online recommendation platforms before making consumption decisions. Research on the wisdom-of-the-crowd phenomenon suggests that average ratings provide unbiased quality estimates. Yet we argue that the process by which average ratings are updated creates a systematic bias. In analyses of more than 80 million online ratings, we found that items with high average ratings tend to attract more additional ratings than items with low average ratings. We call this asymmetry in how average ratings are updated endogenous crowd formation. Using computer simulations, we showed that it implies the emergence of a negative bias in average ratings. This bias affects items with few ratings particularly strongly, which leads to ranking mistakes. The average-rating rankings of items with few ratings are worse than their quality rankings. We found evidence for the predicted pattern of biases in an experiment and in analyses of large online-rating data sets.
Roles of the fission yeast UNC-13/Munc13 protein Ync13 in late stages of cytokinesis

Cytokinesis is a complicated yet conserved step of the cell-division cycle that requires the coordination of multiple proteins and cellular processes. Here we describe a previously uncharacterized protein, Ync13, and its roles during fission yeast cytokinesis. Ync13 is a member of the UNC-13/Munc13 protein family, whose animal homologues are essential priming factors for soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex assembly during exocytosis in various cell types, but no roles in cytokinesis have been reported. We find that Ync13 binds to lipids in vitro and dynamically localizes to the plasma membrane at cell tips during interphase and at the division site during cytokinesis. Deletion of Ync13 leads to defective septation and exocytosis, uneven distribution of cell-wall enzymes and components of cell-wall integrity pathway along the division site and massive cell lysis during cell separation. Interestingly, loss of Ync13 compromises endocytic site selection at the division plane. Collectively, we find that Ync13 has a novel function as an UNC-13/Munc13 protein in coordinating exocytosis, endocytosis, and cell-wall integrity during fission yeast cytokinesis.