Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparative camera calibrations of some 'off the shelf' digital cameras suited to archaeological purposes.

The increasing availability and capability of "off the shelf" low cost digital cameras coupled with on-going advances in mobile computing technology offer great potential for on-site archaeological recording. In particular the userfriendliness and ready availability of these systems coupled with image orientated modelling software packages such as Photo Modeller and Photo Builder are providing systems that are increasingly suited to the requirements of on-site archaeological recording. However, whilst offering ease of use, the geometric performance and imaging stability of all "off the shelf" systems are extremely dependant on the manner in which they are used and the selection of an appropriate calibration method. This paper, through a series of calibration experiments, investigates the suitability and geometric stability of three such camera systems: a pair of Kodak DC210 cameras, a pair of Kodak DC260 cameras and a Canon DV1 digital video camcorder used in both still and video imaging modes. The work undertaken demonstrates that all three systems are capable of attaining measurements to sub-pixel accuracy provided that the image acquisition methodology adopted for each camera takes into account and compensates for the particular design features of each system. In particular it is noted that some of the design features aimed at promoting ease of "snap shot" photography must be circumvented if camera internal geometry is to remain at best stable or at least reproducible.
The Signalling Hypothesis Revisited: Evidence from Foreign IPOs

While the signaling hypothesis has played a prominent role as the economic rationale associated with the initial public offering (IPO) underpricing puzzle (Welch (1989)), the empirical evidence on it has been mixed at best (Jegadeesh, Weinstein, and Welch (1993), Michaely and Shaw (1994)). This paper revisits the issue from the vantage point of close to two decades of additional experience by examining a sample of foreign IPOs—firms from both financially integrated and segmented markets—in U.S. markets. The evidence indicates that signaling does matter in determining IPO underpricing, especially for firms domiciled in countries with segmented markets, which as a result face higher information asymmetry and lack access to external capital markets. We find a significant positive and robust relationship between the degree of IPO underpricing and segmented-market firms’ seasoned equity offering (SEO) activities. For firms from integrated markets, in contrast, the analyst-coverage purchase hypothesis appears to matter more in explaining IPO underpricing, and the aftermarket price appreciation explains these firms’ SEO activities. The evidence, therefore, clearly supports the notion that some firms are willing to leave money on the table voluntarily to get a more favorable price at seasoned offerings when they are substantially wealth constrained, a prediction embedded in the signaling hypothesis.
Penetrating the Virus Monitoring and Analysis System Using Delayed Trigger Technique

Virus Monitoring and Analysis System (VMAS) is generally used for monitoring and capturing virus behavior, and it can produce a report analysis which can be used by expert user to learn virus activity. There are several tools which have this capability, such as: Joebox, ThreatExpert, CWSandbox, and Sysinternals. Turns out, these tools are not fully perfect in analyzing the virus behavior. Therefore in this paper, we propose a technique to defeat such tools, by exploiting the limitation of VMAS in term of time monitoring, by introducing a new virus exploiting technique called Delayed Trigger Technique (DTT). KeywordsVirus Analysis; Behavior Monitor
lymphocytic leukemia to Richter syndrome Two main genetic pathways lead to the transformation of chronic

Ott, Emanuele Zucca, Gianluca Gaidano and Francesco Bertoni Matolcsy, Dominic Spagnolo, Eugene Nikitin, Alberto Zamò, Valter Gattei, Govind Bhagat, German Cogliatti, Hana Votavova, Steven H. Swerdlow, Stephan Stilgenbauer, Miguel A. Piris, Andras Marco Lucioni, Roberto Marasca, Giorgio Inghirami, Marco Ladetto, Francesco Forconi, Sergio Young, Fiona Murray, Richard Rosenquist, Timothy C. Greiner, Wing C. Chan, Ester M. Orlandi, Strefford, David Oscier, Kostas Stamatopoulos, Theodora Papadaki, Francoise Berger, Ken H. Ekaterina Chigrinova, Andrea Rinaldi, Ivo Kwee, Davide Rossi, Paola M. V. Rancoita, Jonathan C. lymphocytic leukemia to Richter syndrome Two main genetic pathways lead to the transformation of chronic
Cytotoxicity of Enterolobium timbouva Plant Extract and Its Isolated Pure Compounds

Aims: The present study aimed to evaluate the cytotoxic activities of the aqueous alcohol extract of Enterolobium timbouva leaves as well as its isolated pure compounds. Place and Duration of Study: Department of Pharmacognosy, Faculty of pharmacy, Ain Shams University, between March 2010 and May 2012. Methodology: In vitro Cytotoxic study was conducted for the aqueous methanol extract and the isolated pure single compounds to determine the IC50 by sulphorhodamine B (SRB) assay. Results: Phytochemical investigation of the extract resulted in the isolation and structural determination of ten phenolic compounds isolated for the first time from entitled genus viz; 3,4-Dihydroxy-Cinnamic acid (Caffeic acid) (1); Quercetin-3-O-β-D-glucopyranoside (Isoquercitrin) (2); Quercetin-3-O-β-D-galacto-pyranoside (Hyperin) (3); Kaempferol-3-Oβ-D–glucopyranoside (Astragalin) (4); Hesperetin-7-O-rutinoside (Hesperidin) (5); Quercetin 3-O-rutinoside (Rutin) (6); Quercetin (7); Kaempferol (8); 7-methoxycoumarin (Herniarin) (9); and Chrysin (10). The aqueous alcohol extract exhibited potent cytotoxic activity against diffferent cancer cell lines with IC50 values of 2.67 μg/mL against MCF-7 Original Research Article British Journal of Pharmaceutical Research, 4(7): 826-836, 2014 827 cell line, 3.89 μg/ml against HCT116 cells, 4 μg/mL against HEp2 cells, 4.5 μg/mL against HeLa cells, 1.7 μg/mL against PC-3 cells, and 5.7 μg/mL against Huh-7 cells. In vitro cytotoxic assay of the isolated pure compounds against Huh-7 cell Line showed that compounds 1, 9 and 10 are the only tested compounds exhibiting potent cytotoxic activity with IC50 of 3 μg/mL, 0.76 μg/mL, and 18.51 μg/mL respectively. The rest of tested compounds exhibited IC50 exceeding 1000 μg/mL which reflects their safety. Conclusion: The current study indicated that the phenolic compounds isolated from Enterolobium timbouva leaves are promising molecules with potentially useful cytotoxic activity profiles. This confirms that this terrestrial plant has great value as a source of lead compounds with pharmaceutical applications.
Seasonal Variations Affect the Physicochemical Composition of Bufallo Milk and Artisanal Cheeses Produced in Marajó Island (Pa, Brazil)

This research was carried out to evaluate the influence of seasonal variation in physicochemical composition and microbiological profile of buffalo milk and of the artisanal cream and butter types cheeses produced on Marajo Island. Eighteen farms located of the island were involved in the study. Milk and cheese quality were evaluated in two typical seasons. The rainy, from January to June and dry, from July to December. Samples were submitted to a detailed set of laboratorial analyses. Physicochemical composition of buffalo milk was influenced by the seasons. Compared to rainy, the dry period showed an increase in fat (5.53±0.71 to 6.74±1.19) and lactose (4.77±0.20 to 5.20±0.20) concentrations and reduction in total solids (16.89±0.92 to 15.77±1.54), nonfat dry matter (9.94±0.36 to 8.99±1.23) and minerals (0.84±0.12 to 0.62±0.09) concentrations (p<0.05). The season influence was observed in physicochemical composition of both cheese-types. Compared to rainy season, in the cream cheese type, higher values (p<0.05) were found for titratable acidity (0.63±0.02 to 0.78±0.15), fat (32.38±3.22 to 36.89±4.59), fat in the dry matter (55.06±3.26 to 63.92±2.49) but lower values for water activity (0.99±0.02 to 0.49±0.03), minerals (2.37±0.55 to 1.40±0.02) and calcium (0.28±0.08 to 0.18±0.07). For the butter cheese type, in the dry season, higher values were found only for titratable acidity (0.49±0.02 to 0.38±0.0) and lower values for water activity (0.18±0.07 to 0.45±0.08). The study have shown that some components of the buffalo milk and artisanal cheeses produced on Marajo Island are influenced by the dry and rainy typical seasons and therefore, some sensory variations are expected around the year.
G00-1411 Biosecurity Basics for Cattle Operations and Good Management Practices (GMP) for Controlling Infectious Diseases

The goal of biosecurity is to stop transmission of disease causing agents by preventing, minimizing or controlling cross-contamination of body fluids (feces, urine, saliva, etc.) between animals, animals to feed and animals to equipment that may directly or indirectly contact animals. Biosecurity management practices are designed to prevent the spread of disease by minimizing the movement of biologic organisms and their vectors (viruses, bacteria, rodents, flies, etc.) onto and within your operation. Biosecurity can be very difficult to maintain because the interrelationships between management, biologic organisms and biosecurity are very complex. While developing and maintaining biosecurity is difficult, it is the cheapest, most effective means of disease control available, and no disease prevention program will work without it. Infectious diseases can be spread between operations by:
A GAS RETAIL STOCHASTIC OPTIMIZATION MODEL BY MEAN REVERTING TEMPERATURE SCENARIOS

The paper deals with a new stochastic optimization model, named OMoGaS-SV (Optimisation Modelling for Gas Seller-Stochastic Version), to assist companies dealing with gas retail commercialization. Stochasticity is due to the dependence of consumptions on temperature uncertainty. Due to nonlinearities present in the objective function, the model can be classified as an NLP mixed integer model, with the profit function depending on the number of contracts with the final consumers, the typology of such consumers and the cost supported to meet the final demand. Constraints related to a maximum daily gas consumption, to yearly maximum and minimum consumption in order to avoid penalties and to consumption profiles are included. The results obtained by the stochastic version give clear indication of the amount of losses that may appear in the gas seller’s budget.
ltrasound image texture analysis of the intima and media layers of the ommon carotid artery and its correlation with age and gender

The intima–media thickness (IMT) of the common carotid artery (CCA) is widely used as an early indicator of cardiovascular disease (CVD). It was proposed but not thoroughly investigated that the composition and texture of the media layer (ML) can be used as an indicator for the risk of stroke. In this study, we investigate the application of texture analysis of the ML of the CCA and how texture is affected by age and gender. The study was performed on 100 longitudinal-section ultrasound images acquired from asymptomatic subjects at risk of atherosclerosis. The images were separated into three different age groups, namely below 50, 50–60, and above 60 years old. Furthermore, the images were separated according to gender. A total of 61 different texture features were extracted from the intima layer (IL), the ML, and the intima–media complex (IMC). The ML and the IMC were segmented manually by a neurovascular expert
A cc ep te d A rti cl e Table 1 Patient characteristics at baseline and after treatments

This article is protected by copyright. All rights reserved. This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/jdb.12555 A cc ep te d A rti cl e Objective: To compare the effects of gliclazide, liraglutide, and metformin in type 2 diabetes mellitus (T2DM) patients with non-alcoholic fatty liver disease (NAFLD). Methods: Eighty-seven subjects were randomized to receive liraglutide, metformin, or gliclazide for 24 weeks. Primary outcomes included hemoglobin A1c (HbA1c) levels, intrahepatic fat (IHF) content, and liver function. Results: HbA1c levels and IHF content reduced after treatment in the three groups. HbA1c levels were lower in the liraglutide and metformin groups than in the gliclazide group, and reductions in IHF content were greater with liraglutide than with gliclazide. Liraglutide and metformin treatments reduced weight and improved liver function. Changes in IHF content were positively correlated with reductions in serum alanine aminotransferase (ALT) and triglyceride levels and weight. At 24 weeks, IHF content reductions were greater in those with weight loss ≥ 5%, changes in waist circumference ≤ 0 cm, HbA1c level reduction ≥ 2.5%, and HbA1c level < 6.5%. Conclusions: In T2DM patients with NAFLD, compared to liraglutide and metformin, gliclazide resulted in less improvement in liver function, reductions in IHF content and HbA1c level, and weight loss, and the slightly better improvements were achieved with liraglutide than with metformin.
Running title : BOB 1-specific TCR gene therapy B-cell malignancies Scientific category : Gene therapy Corresponding

Lorenz Jahn, Pleun Hombrink, Renate S. Hagedoorn, Michel G.D. Kester, Dirk M. van der Steen, Tania Rodriguez, Tsvetelina Pentcheva-Hoang, Arnoud H. de Ru, Marjolein P. Schoonakker, Miranda H. Meeuwsen, Marieke Griffioen, Peter A. van Veelen, J.H. Frederik Falkenburg and Mirjam H.M. Heemskerk Department of Hematology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands; Department of Hematopoiesis, Sanquin Research, P.O. Box 9190, 1006 AD Amsterdam, The Netherlands; Research and Development, Bellicum Pharmaceuticals, Inc., 77030 Houston, Texas; Center for Proteomics and Metabolomics,
A Small Quad-Band Monopole Antenna with Folded Strip Lines for WiMAX/WLAN and ITU Applications

In this article, a small Quad-Band microstrip patch antenna with folded strip lines for WiMAX/WLAN and ITU Applications is presented. This antenna consists of eight symmetrical rectangular folded strip lines with 2 PIN diodes, ground plane and dimensions of 15 -20 -1.6mm 3 . Using PIN diodes integrated within the antenna configuration, the antenna would be able to operate in two modes. The operational frequency bands of antenna are WLAN (2.4/5.2/5.8GHz), WiMAX (3.5/5.5GHz) and ITU-Region 1 allocation (4.3GHz) when diodes=on. In this design approach of antenna, omnidirectional radiation pattern andÂ Â Â Â Â Â Â S 11 -10dB bandwidths are obtained for all frequency bands. This antenna is fabricated on FR4 substrate with permittivity of 4.4 and loss tangent of 0.024.
Running head : bococizumab injection site PK study

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/1755-5922.12278 This article is protected by copyright. All rights reserved. Article type : Original Research Article
Epidemiology of Malaria Parasites Infection among Pregnant Women in Some Part of Nasarawa State, Nigeria

The study was carried out to determine the prevalence of malaria parasites infection among pregnant women in some selected areas of Nasarawa State. It was assessed from April to September, 2014 (period of high malaria transmission). Both thick and thin films were made and stained using parasitological standard procedures. Of the 360 samples examined, 316 (88%) had malaria in their blood. Age group 25 – 28 years recorded the highest prevalence rate and mean parasite density of 93.5% and 999 d1-1 and the difference between the pregnant women and age groups were statistically significant (P<0.05). Illiterate pregnant women had the highest mean parasite density of 840 dl-1 with (97.3%) prevalence rate. Drugs used were also considered in which local herbs had 100% sensitive to plasmodium falciparum than orthodox curative drugs. Keywords : Malaria, parasite, pregnancy, plasmodium falciparum
Comparison between Conventional Methods and Intelligent Methods for Maximum Power Point Tracking Solar PV System

In recent years a lot of attention has been given towards application solar energy. The advantages of photovoltaic (PV) systems is the lack of greenhouse gas emission, lesser Maintenance costs, fewer limitations with respect to installation and absence of mechanical noise due to moving parts. The paper explains the behavior of various Maximum Power Point Tracking (MPPT) strategies applied to solar PV systems: Perturb and Observe , method of incremental conductance, and fuzzy logic based. The brief description of each method is given then the comparison is done by considering criteria are simplicity of implementation, irradiance variations.
1 Identification of Novel Mutational Drivers Reveals Oncogene Dependencies In Multiple Myeloma . Short title : Oncogene dependencies in myeloma

Understanding the profile of oncogene and tumor suppressor gene mutations with their interactions and impact on the prognosis of multiple myeloma (MM) can improve the definition of disease subsets and identify pathways important in disease pathobiology. Using integrated genomics of 1,273 newly diagnosed patients with multiple myeloma we identify 63 driver genes, some of which are novel including IDH1, IDH2, HUWE1, KLHL6, and PTPN11. Oncogene mutations are significantly more clonal than tumor suppressor mutations, indicating they may exert a bigger selective pressure. Patients with more mutations in driver genes are associated with a worse outcome, as are those with identified mechanisms of genomic instability. Oncogenic dependencies were identified between mutations in driver genes, common regions of copy number change, and primary translocation and hyperdiploidy events. These dependencies included associations with t(4;14) and mutations in FGFR3, DIS3 and PRKD2; t(11;14) with mutations in CCND1 and IRF4; t(14;16) with mutations in MAF, BRAF, DIS3 and ATM; and hyperdiploidy with gain 11q, mutations in FAM46C and MYC rearrangements. These associations indicate that the genomic landscape of myeloma is pre-determined by the primary events upon which further dependencies are built, giving rise to a nonrandom accumulation of genetic hits. Understanding these dependencies may elucidate potential evolutionary patterns and lead to better treatment regimens. For personal use only. on June 8, 2018. by guest www.bloodjournal. org From
Cycling Performance of Supercapacitors Assembled with Polypyrrole/Multi-Walled Carbon Nanotube/Conductive Carbon Composite Electrodes

Polypyrrole (PPy)/multi-walled carbon nanotube (MWCNT)/conductive carbon (CC) composites are synthesized by the chemical oxidative polymerization method. The morphology analysis of the composite materials indicates uniform coating of PPy over MWCNTs and conductive carbon. The electrochemical performances of PPy/MWCNT/CC composites with different compositions are evaluated in order to optimize the composition of the composite electrode. Galvanostatic chargedischarge measurements and electrochemical impedance spectroscopy studies prove the excellent cycling stability of the PPy/MWCNT/CC composite electrodes.
Reinforcement Learning for LTL f / LDL f Goals

MDPs extended with LTLf /LDLf non-Markovian rewards have recently attracted interest as a way to specify rewards declaratively. In this paper, we discuss how a reinforcement learning agent can learn policies fulfilling LTLf /LDLf goals. In particular we focus on the case where we have two separate representations of the world: one for the agent, using the (predefined, possibly low-level) features available to it, and one for the goal, expressed in terms of high-level (humanunderstandable) fluents. We formally define the problem and show how it can be solved. Moreover, we provide experimental evidence that keeping the RL agent feature space separated from the goal’s can work in practice, showing interesting cases where the agent can indeed learn a policy that fulfills the LTLf /LDLf goal using only its features (augmented with additional memory).
Outburst activity in comets I. Continuous monitoring of comet 29P/Schwassmann-Wachmann 1

Aims. We carried out a continuous monitoring of comet 29P/Schwassmann-Wachmann 1 by using medium aperture telescopes with the aim of studying the activity and outburst mechanisms of this comet on the basis of photometric variations. Methods. We used a standardized method to obtain the coma photometry in the R filter of the Johnson-Kron-Cousins system. Some abrupt changes observed in the brightness of SW1 suggest important variations in surface activity with time. Results. During our 2002-2007 observational campaign we detected 28 outbursts (of 1 mag or larger) in 29P/Schwassmann-Wachmann 1. A typical outburst is characterized by a rapid increase towards maximum (in a few hours) and a slower decrease toward the quiescent level (in 3-4 days). Given the effective observing time, the average outburst rate is 7.3 events per year. Despite well-sampled data, no signs of a clear periodicity in the outburst occurrence has been found, thus confirming the unpredictability of the activity of this comet.
Modeled changes in 100 year Flood Risk and Asset Damages within Mapped Floodplains of the Contiguous United States

A growing body of recent work suggests that the extreme weather events that drive inland flooding are likely to increase in frequency and magnitude in a warming climate, thus increasing flooding damages in the future. We use hydrologic projections based on the Coupled Model Intercomparison Project Phase 5 (CMIP5) to estimate changes in the frequency of modeled 1 % annual exceedance probability flood events at 57 116 locations across the contiguous United States (CONUS). We link these flood projections to a database of assets within mapped flood hazard zones to model changes in inland flooding damages throughout the CONUS over the remainder of the 21st century. Our model generates early 21st century flood damages that reasonably approximate the range of historical observations, and trajectories of future damages that vary substantially depending on the greenhouse gas (GHG) emissions pathway. The difference in modeled flood damages between higher and lower emissions pathways approaches $ 4 billion per year by 2100 (in undiscounted 2014 dollars), suggesting that aggressive GHG emissions reductions could generate significant monetary benefits over the long-term in terms of reduced flood risk. Although the downscaled hydrologic data we used have been applied to flood impacts studies elsewhere, this research expands on earlier work to quantify changes in flood risk by linking future flood exposure to assets and damages at a national scale. This work uses relatively conservative assumptions and methods that ultimately affect damage estimates; future work is needed to test sensitivity related to these methodological choices (e.g., more sophisticated downscaling methods, use of multiple hydrologic models, and consideration of a wider range of flood magnitudes).