Miracle-dz/UniFAR-FTUs huggingface dataset:
The BLUE Framework: Designing User-Centered In-Product Feedback for Large Scale Applications

In-product feedback mechanisms allow for capturing user feedback while the user is engaging with the product or service. Traditionally in-product feedback has focused on metrics such as Net Promoter Score (NPS) [21] and Customer Satisfaction (CSAT) [5] which look to measure customer loyalty or overall product satisfaction. By introducing complementary user experience (UX) metrics that are focused on user outcomes, UX teams have greater insight into measuring the successes or challenges of their users in the context of use. This case study describes and discusses the process employed and the lessons learned while designing and implementing a user-centered in-product feedback system. We specifically call out challenges and opportunities around aligning with business outcomes, navigating current frameworks, unlocking self-serve data to stakeholders, informing strategy, and feeding additional research. In conclusion, we present these learnings as a framework, dubbed BLUE, to help other UX teams create in-product feedback mechanisms.
Five-level inverter for solar photovoltaic grid-connected power generation

In order to realize solar photovoltaic grid-connected power generation better,on the basis of two-level inverter for solar photovoltaic grid power generation,and by improving the structure of DC-DC transformer and adopting the modulation strategy to produce step wave with minimum low order harmonic quantity,a new-type of five-level inverter is devised.Simulink is used to simulate the single-phase system model of the new-type of five-level inverter.The result shows that the output voltage harmonic content of the new-type of five-level inverter is cut obviously under the same output level and the inverting efficiency increases as compared to two-level inverters.And the new-type of five-level inverter is suitable to solar photovoltaic grid-connected power generation with low voltage input and high voltage high-power output.
Endothelin Receptor Type A in stomach adenocarcinoma

4 Zhengguang Wang, Kangchun Wang, Xue Yu, ,Moye Chen ,Yaqi Du * 5 6 1 Department of Gastroenterology, The First Affiliated Hospital of China Medical University, 7 Shenyang, Liaoning, China 8 2 Department of Orthopedics, The First Affiliated Hospital of China Medical University, 9 Shenyang, Liaoning, China 10 3 Department of Organ transplantation and Hepatobiliary, The First Affiliated Hospital of China 11 Medical University, Shenyang, Liaoning, China 12 4 Department of Paediatrics, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare 13 Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 14 China. 15 16 *Corresponding Author: Yaqi Du 17 Email address: yqdu@cmu.edu. cn 18
Efficient and Traceable Anonymous Credentials on Smart Cards

Anonymous credential (AC) systems allow users, obtaining a credential on a set of attributes, to anonymously prove ownership of the credential and then to selectively disclose a subset of attributes without leaking any other attributes. Recently, a new type of AC, called keyed-verification anonymous credential (KVAC), has been proposed, which indicates that the credential issuer is also the verifier. Conceptually, the KVAC system is suitable for being used as employee cards, library access cards or eIDs (electronic ID cards). However, since the limited process power of smart cards, most of the existing KVAC systems are hard to be implemented on them. In addition, none of the existing KVAC systems provide traceability to obtain the user’s identity if anyone tries to misbehave with KVAC. In this paper, we present the first efficient and traceable KVAC system designated for smart cards. Our scheme provides the following security properties: unforgeability, anonymity, traceability and unlinkability. To demonstrate the efficiency and feasibility, we present an implementation of our scheme on standard Multos smart cards. The implementation results show that our scheme is efficient enough for practical use.
Fully Printable Low-Cost Dexterous Soft Robotic Manipulators for Agriculture

Further automation of agricultural tasks will require the development of new dexterous end-effectors that are capable of directly interacting with soil and vegetation alongside human workers. Soft robotic end-effectors are poised to provide feasible low-cost solutions, but their design and fabrication process is still time-consuming, difficult, and not well established. In this work, we present an approach that utilizes novel low-cost fabrication techniques in conjunction with design tools helping soft hand designers to systematically take advantage of multi-material 3D printing to create dexterous soft robotic end-effectors. While very low-cost and lightweight, we show that generated designs are highly durable, surprisingly strong, and capable of dexterous grasping, making the technology an ideal candidate for real-world agricultural ap-
Faster and Better Grammar-based Text-to-SQL Parsing via Clause-level Parallel Decoding and Alignment Loss

Grammar-based parsers have achieved high performance in the cross-domain text-to-SQL parsing task, but suffer from low decoding efficiency due to the much larger number of actions for grammar selection than that of tokens in SQL queries. Meanwhile, how to better align SQL clauses and question segments has been a key challenge for parsing performance. Therefore, this paper proposes clause-level parallel decoding and alignment loss to enhance two high-performance grammar-based parsers, i.e., RATSQL and LGESQL. Experimental results of two parsers show that our method obtains consistent improvements both in accuracy and decoding speed.
Central bank independence under threat?

“comes both from the wider political and social climate – the rise of populism and of anti-establishment, anti-expert and antitechnocratic sentiment – and from developments specific to central banks. Since the start of the Great Financial Crisis (GFC) in mid-2007, central banks in most advanced economies have become more powerful and political. They have not become more accountable. Their mandates have expanded far beyond monetary policy narrowly defined. ” (Buiter, 2016: 3).
Diabetes Without Impeding Viral Clearance Choriomeningitis Virus) Autoimmune Induced (Rat Insulin Promoter-Lymphocytic Nonmitogenic CD3 Antibody Reverses Virally

† Treatment with nonmitogenic CD3 Ab reverses established autoimmune diabetes in nonobese diabetic mice by restoring self-tolerance, and is currently under clinical evaluation in patients presenting recent onset type I diabetes. Due to the immunosuppressive potential of this strategy, it was relevant to explore how this treatment would inﬂuence the outcome of concomitant viral infections. In this study, we used a transgenic model of virally induced autoimmune diabetes (rat insulin promoter-lymphocytic choriomeningitis virus) that allows for more precise tracking of the autoaggressive response and choice of the time point for initiation of autoimmunity. CD3 was most effective during a clearly deﬁned prediabetic phase and prevented up to 100% of diabetes by drastically lowering activation of autoaggressive CD8 lymphocytes and their production of inﬂammatory cytokines. Interestingly, reversion of established disease could be achieved as well, when nonmitogenic CD3 was administered late during pathogenesis to overtly diabetic recipients. Most importantly, competence to clear viral infections was maintained. Thus, administration of nonmitogenic CD3 prevents diabetes by sufﬁcient systemic reduction of (auto)aggressive lymphocytes, but without compromising antiviral immune competence. The Journal of Immunology, 2002, 168: 933–941.
How to design taskification in video games. A framework for purposeful game-based crowdsourcing

When it comes to citizen science, games can play an important role encouraging voluntary engagement of the public in activities contributing to scientific investigation. This considering that, on the one hand, what appears as an interesting and challenging scientific topic may not be seen as captivating and engaging for the general public; on the other, that to address a scientific challenge it is often required a level of knowledge that acts a barrier to access. Consequently, it comes the necessity to develop projects with scientific tasks that can be accomplished by novices, while ensuring the interest of experts. In this context, game-based crowdsourcing approaches and taskification in particular can serve as powerful motivation systems. By integrating seamlessly the task into an established game experience, it is possible to target players and direct them to perform the crowdsourcing activity. Situated at the intersection of the three theoretical domains of gamification, serious games, and crowdsourcing game systems, this paper presents a framework to taskify games with crowdsourcing activities. Considering the role that coherently built story-worlds, narrative, and game mechanics play, the framework aims at providing designers with clear guidance for building purposeful crowdsourcing activities within video games.
5 D Deep Learning Inversion of LWD and Deep-Sensing EM Measurements Across Formations with Dipping Faults W

Deep learning (DL) inversion of induction logging measurements is used in well geosteering for real-time imaging of the distribution of subsurface electrical conductivity. We develop a DL inversion workflow to solve 2.5-dimensional (2.5D) inverse problems arising in well geosteering. The inversion workflow employs three DL modules: a “look-around” fault detection module and two inversion modules for reconstructing anisotropic resistivity models in the presence or absence of fault planes, respectively. Our DL approach is capable of detecting and quantifying arbitrary dipping fault planes in real-time. We compare inversion performance considering only short loggingwhile-drilling (LWD) measurements vs. using both short LWD and deep-sensing measurements. The latter measurements provide enhanced depth-of-investigation while minimizing uncertainty. We also obtain improved results when using multidimensional inversion, especially nearby fault planes. This study verifies the applicability of real-time 2.5D DL inversion across arbitrary faulted formations for well geosteering.
OPTIMIZED DESIGN OF A SIMPLE SUPPORTED ONE-WAY RC SLAB UNDER BLAST LOADS BY ENERGY APPROACH

The area under resistance-deflection(R-y)curve of reinforced concrete(RC)slab gives the energy which a RC slab can absorb when subjected to the blast loads.For the RC simple supported one-way slab under blast loads,a bilinear model is used to simulate the R-y curve in the analysis of blast dynamic response.After comparing the areas under the R-y curves of RC slabs with different reinforcement ratios,the reinforcement ratio responding to the biggest area can be defined as the optimal reinforcement ratio.Because the effects of nonlinearity of the material and the strain rate on the reinforced concrete and reinforcing steel should be considered,a layered method is used to determine the R-y curves and the dynamic response of slabs.The derived results can be used to optimiz design of RC simply supported one-way slabs.
Glymphatic system dysfunction in temporal lobe epilepsy patients with hippocampal sclerosis

This study aimed to evaluate glymphatic system function in temporal lobe epilepsy (TLE) patients with hippocampal sclerosis (HS) in comparison to healthy controls, using diffusion tensor imaging (DTI)‐analysis along the perivascular space (ALPS) method. We hypothesized that there is glymphatic system dysfunction in TLE patients with HS.
Regulation of mTOR complexes in long-lived growth hormone receptor knockout and Snell dwarf mice

Downregulation of mTOR (mechanistic target of rapamycin) can extend lifespan in multiple species, including mice. Growth hormone receptor knockout mice (GHRKO) and Snell dwarf mice have 40% or greater lifespan increase, and have lower mTORC1 function, which might reflect alteration in mTORC1 components or alteration of upstream proteins that modulate mTOR activity. Here we report reduction of mTORC components DEPTOR and PRAS40 in liver of these long-lived mice; these changes are opposite in direction to those that would be expected to lead to lower mTORC1 function. In contrast, levels of the upstream regulators TSC1 and TSC2 are elevated in GHRKO and Snell liver, kidney and skeletal muscle, and the ratio of phosphorylated TSC2 to total TSC2 is lower in the tissues of the long-lived mutant mice. In addition, knocking down TSC2 in GHRKO fibroblasts reversed the effects of the GHRKO mutation on mTORC1 function. Thus increased amounts of unphosphorylated, active, inhibitory TSC may contribute to lower mTORC1 function in these mice.
Stakeholders’ views on the use of psychotropic medication in older people: a systematic review

Abstract Background psychotropic medication use has been shown to increase with age and has been associated with increased risk of falls, strokes and mortality. Various guidelines, regulations and tools have been developed to reduce inappropriate prescribing, but this remains high. In order to understand the reasons for this, we aimed to systematically review healthcare professionals’, patients’ and family caregivers’ attitudes towards the use of psychotropic medication in older people. Methods a systematic literature search was carried out from inception to September 2020 using PUBMED, EMBASE, PsycINFO and CINAHL and hand-searching of reference lists. Included studies investigated stakeholder views on psychotropic in adults over the age of 65. Findings were thematically synthesised. Results overall, there was an acceptance of long-term psychotropic medication for older people both living in the community and in residential care. While healthcare professionals were aware of guidelines for the use of benzodiazepines and psychotropic medicines, they identified barriers to following them on individual, team and organisational levels. Alternative non-pharmacological approaches were not always available or accepted by patients. Conclusion psychotropic medicine use in older adults remains a complex issue, which needs to be addressed on a broad level. Attitudes of older people and healthcare professionals encourage long-term use. Meanwhile, various internal and external factors act as barriers to the use of non-drug alternatives in this population. In order to reduce overprescribing of psychotropics, there is a need to increase the acceptability and accessibility of alternative interventions in both care homes and the community.
The distribution of sexual function in the flowering plant: from monoecy to dioecy

In flowering plants, male and female functions are usually closely associated in the same flowers, as predicted by resource allocation theory. However, the benefits of outbreeding can lead to unisexual flowers and the physiological control of their distribution across the plant (monoecy). Monoecy is thought to be a major route to dioecy (separation of sexual function of different individuals). The developmental and functional problems associated with unisexual flowers may thus be solved at the level of the evolution of monoecy. Consequently, the evolution of dioecy from monoecy requires mutations in only a single gene. Here various scenarios (conceptual models) are presented for the evolution of monoecy and dioecy, including scenarios consistent with known cases of single-gene control of dioecy, such as in Populus, and the artificial breeding of dioecy from monoecy experimentally achieved in Zea and Cucumis. Attention is also drawn here to the phenomenon of pleogamy, the minor or occasional occurrence of additional sex morphs within a species, which may provide important information about the genetic and developmental control of various sexual systems. This article is part of the theme issue ‘Sex determination and sex chromosome evolution in land plants’.
Microbiomes of Hadal Fishes across Trench Habitats Contain Similar Taxa and Known Piezophiles

Hadal trenches, characterized by high hydrostatic pressures and low temperatures, are one of the most extreme environments on our planet. By examining the microbiome of abyssal and hadal fishes, we provide insight into the diversity and distribution of host-associated life at great depth. ABSTRACT Hadal snailfishes are the deepest-living fishes in the ocean, inhabiting trenches from depths of ∼6,000 to 8,000 m. While the microbial communities in trench environments have begun to be characterized, the microbes associated with hadal megafauna remain relatively unknown. Here, we describe the gut microbiomes of two hadal snailfishes, Pseudoliparis swirei (Mariana Trench) and Notoliparis kermadecensis (Kermadec Trench), using 16S rRNA gene amplicon sequencing. We contextualize these microbiomes with comparisons to the abyssal macrourid Coryphaenoides yaquinae and the continental shelf-dwelling snailfish Careproctus melanurus. The microbial communities of the hadal snailfishes were distinct from their shallower counterparts and were dominated by the same sequences related to the Mycoplasmataceae and Desulfovibrionaceae. These shared taxa indicate that symbiont lineages have remained similar to the ancestral symbiont since their geographic separation or that they are dispersed between geographically distant trenches and subsequently colonize specific hosts. The abyssal and hadal fishes contained sequences related to known, cultured piezophiles, microbes that grow optimally under high hydrostatic pressure, including Psychromonas, Moritella, and Shewanella. These taxa are adept at colonizing nutrient-rich environments present in the deep ocean, such as on particles and in the guts of hosts, and we hypothesize they could make a dietary contribution to deep-sea fishes by degrading chitin and producing fatty acids. We characterize the gut microbiota within some of the deepest fishes to provide new insight into the diversity and distribution of host-associated microbial taxa and the potential of these animals, and the microbes they harbor, for understanding adaptation to deep-sea habitats. IMPORTANCE Hadal trenches, characterized by high hydrostatic pressures and low temperatures, are one of the most extreme environments on our planet. By examining the microbiome of abyssal and hadal fishes, we provide insight into the diversity and distribution of host-associated life at great depth. Our findings show that there are similar microbial populations in fishes geographically separated by thousands of miles, reflecting strong selection for specific microbial lineages. Only a few psychropiezophilic taxa, which do not reflect the diversity of microbial life at great depth, have been successfully isolated in the laboratory. Our examination of deep-sea fish microbiomes shows that typical high-pressure culturing methodologies, which have largely remained unchanged since the pioneering work of Claude ZoBell in the 1950s, may simulate the chemical environment found in animal guts and helps explain why the same deep-sea genera are consistently isolated.
Direct Real-Time PCR for the Detection and Serotyping of Haemophilus influenzae without DNA Extraction

To monitor the burden and changes in Haemophilus influenzae (Hi) disease, direct real-time PCR (drt-PCR) assays have been developed for Hi detection in monoplex form and its six serotypes in triplex form, directly from cerebrospinal fluid (CSF) specimens. These assays target the phoB gene for the species detection (Hi-phoB) and serotype-specific genes in region II of the capsule biosynthesis locus (Hi-abf and Hi-cde), identified through comparative analysis of Hi and non-Hi whole-genome sequences. ABSTRACT To monitor the burden and changes in Haemophilus influenzae (Hi) disease, direct real-time PCR (drt-PCR) assays have been developed for Hi detection in monoplex form and its six serotypes in triplex form, directly from cerebrospinal fluid (CSF) specimens. These assays target the phoB gene for the species detection (Hi-phoB) and serotype-specific genes in region II of the capsule biosynthesis locus (Hi-abf and Hi-cde), identified through comparative analysis of Hi and non-Hi whole-genome sequences. The lower limit of detection (LLD) is 293 CFU/mL for the Hi-phoB assay and ranged from 11 to 130 CFU/mL for the triplex serotyping assays. Using culture as a reference method, the sensitivity and specificity of Hi-phoB, Hi-abf, and Hi-cde were 100%. Triplex serotyping assays also showed 100% agreement for each serotype compared to their corresponding monoplex serotyping assay. These highly sensitive and specific drt-PCR assays do not require DNA extraction and thereby reduce the time, cost, and handling required to process CSF specimens. Furthermore, triplex drt-PCR assays combine the detection of three serotypes in a single reaction, further improving testing efficiency, which is critical for laboratories that process high volumes of Hi specimens for surveillance and diagnostic purposes.
Leadership for equality in education: 50 years marching forward or marching on the spot?

This article examines how Educational Management, Administration and Leadership has embodied the values, concepts and practice of the field of educational leadership over 50 years and so played a part in challenging or sustaining inequality in education. The article explores selected key concepts, equal opportunities, diversity, and social justice, the disciplinary base and prevalent research methods underpinning work on inequality, the geographic location and characteristics of relevant published authors and the two areas which attract most attention, gender and ethnicity/race. All areas embody both a push for change and structural inhibitors that limit its extent. Omissions, silences and displacements are also examined, questioning why, for example, a focus on masculinity, white privilege, learner voice and lower status sectors of education hardly surfaces in half a century. The article concludes that despite the positive achievements of the journal in forwarding equality, there is an equality double bind whereby, like a Trojan virus, parameters limiting change are embedded in the very work that seeks to promote it. A number of positive suggestions for changes in the journal and field are made to encourage researchers and practitioners to detect and resist previous strategies of evasion and limitation.