Miracle-dz/UniFAR-FTUs huggingface dataset:
The effects of foot position on balance displayed by classically trained ballerinas in passe

The purpose of the study was to compare the effects of the demi and en pointe foot positions on stability outcomes and balance strategies displayed by ballet dancers during performance of the passé position. Ground reaction force (GRF) and electromyographic (EMG) signals (1200 Hz) of 11 muscles of the supporting limb were obtained, and 3-D spatial positions of reflective markers on the dancer’s body were captured using high-speed digital cameras (120Hz), during the dancer’s performance of 10 passé balance trials in each foot position. Outlines of the dancer’s foot were traced to calculate the size of the base of support (BoS) in each foot position. Stability outcomes of time to stabilization (TTS) and sway area (SA) were derived from GRF and center of pressure data. Balance strategies for each foot position were detected using EMG data to determine muscle synergies using non-negative matrix factorization (NMF); overall muscle contribution (OMC) for each muscle was obtained from the synergies, then the muscles were rank ordered by their OMC; and lower extremity joint moment magnitudes were examined. From paired-samples t-test outcomes (p < .05), dancers en pointe compared to demi pointe had decreased TTS (Cohen’s d = .07), BoS (d = 5.22), SA (d = .89), and mean ankle plantarflexor moments (d = 1.53). To maintain balance en demi pointe, the majority of dancers (~65%) exhibited an ankle strategy as classified by the rank order of the OMC. However, the muscle synergies reflected that hip musculature also contributed to balance. When maintaining balance en pointe, the majority of dancers (~71%) used a ‘whole-limb’ balance strategy, as the muscle synergies and OMC reflected that muscles affecting control of all lower extremity joints contributed to balance. Co-contraction of opposing muscle groups at all joints also was displayed, suggesting a muscle activation strategy of maintaining high joint stiffness to maintain balance during ballet when the body must appear to be motionless. INDEX WORDS: Balance, Biomechanics, Motor control, Neuromuscular control, Dance, Ballet, Electromyography, Center of Force, Center of Pressure, Center of Mass, Non-Negative Matrix Factorization, Base of Support, Sway Area, Time to Stabilization, Muscle Synergy THE EFFECTS OF FOOT POSITION ON BALANCE DISPLAYED BY CLASSICALLY TRAINED BALLERINAS IN PASSÉ by JAYMA RENÉ LALLATHIN B.A. Purdue University, 2005 M.S. Ball State University, 2007 A Dissertation Submitted to the Graduate Faculty of The University of Georgia in Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY ATHENS, GEORGIA 2014 ©2014 Jayma René Lallathin All Rights Reserved THE EFFECTS OF FOOT POSITION ON BALANCE DISPLAYED BY CLASSICALLY TRAINED BALLERINAS IN PASSÉ by JAYMA RENÉ LALLATHIN Major Professor: Kathy J. Simpson Committee: Cathleen Brown Crowell Tim Foutz Electronic Version Approved: Maureen Grasso Dean of the Graduate School The University of Georgia May 2014
A Review of Various Workflow Scheduling Techniques for Grid Computing Environment

— Grid Computing provides resource sharing on large scale and provides platform for development of various computer science engineering applications. Effective scheduling is a key concern for the execution of performance-driven grid applications such as workflows. In this paper, various strategies have been purposed, including static and dynamic Strategies. The former schedules the tasks to resources before the actual execution time and later schedules them at the time of execution. Static scheduling performs better but it is not suitable for dynamic grid environment. Various heuristics or approximations are the performed to obtain near optimal solutions for minimum makespan, computation cost and communication cost of resources. However, in real environment, it is difficult to accurately predict the values due to heterogeneous and dynamic characteristics of grid environment. To have enhanced performance a new scheduling technique is likely to be purposed which will increase the efficiency of the heterogeneous grid also called AWT (Adaptive workflow technique). This approach schedule workflow tasks to the dynamic grid resources based on fact that job having early time (arrival time and service time) minimum will be executed firstly. The overall objective of this paper is to explore the existing research on the heterogeneous grid and scheduling application workflow techniques. Hence this paper ends up with the various challenges in the earlier techniques and also some future directions which can overcome the limitations of the earlier techniques.
DMD060459 2087..2096

Human cytochrome P450 3A4 (CYP3A4) is responsible for the metabolism of more than half of pharmaceutic drugs, and inactivation of CYP3A4 can lead to adverse drug-drug interactions. The substituted imidazole compounds 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl) methyl]-1-piperazinyl]pyrimidine (SCH 66712) and 1-[(2-ethyl-4-methyl1H-imidazol-5-yl)methyl]-4-[4-(trifluoromethyl)-2-pyridinyl]piperazine (EMTPP) have been previously identified as mechanism-based inactivators (MBI) of CYP2D6. The present study shows that both SCH 66712 and EMTPP are also MBIs of CYP3A4. Inhibition of CYP3A4 by SCH 66712 and EMTPP was determined to be concentration, time, and NADPH dependent. In addition, inactivation of CYP3A4 by SCH 66712 was shown to be unaffected by the presence of electrophile scavengers. SCH 66712 displays type I binding to CYP3A4 with a spectral binding constant (Ks) of 42.9 6 2.9 mM. The partition ratios for SCH 66712 and EMTPP were 11 and 94, respectively. Whole protein mass spectrum analysis revealed 1:1 binding stoichiometry of SCH 66712 and EMTPP to CYP3A4 and a mass increase consistent with adduction by the inactivators without addition of oxygen. Heme adduction was not apparent. Multiple monooxygenation products with each inactivator were observed; no other products were apparent. These are the first MBIs to be shown to be potent inactivators of both CYP2D6 and CYP3A4.
Sensorless Control of Synchronous Machines by Linear Approximation of Oversampled Current

The present work examines the potential of current oversampling for the sensorless control of synchronous machines. Using linear regression, the current evolution during a switching state is approximated by a straight line. The approximated offset and slope represent low-noise current and current derivative values. Upon this basis, three position estimation techniques are developed and merged in two oppositional hybrid sensorless control methods which demonstrate the advantages of the oversampling.
Escherichia coli Helicase I1 (UvrD) Protein Can Completely Unwind Fully Duplex Linear and Nicked Circular DNA*

We have examined the duplex DNA unwinding (helicase) properties of the E s c ~ e r i c ~ i u coli helicase I1 protein (uvrD gene product) over a wide range of protein concentrations and solution conditions using a variety of duplex DNA substrates including fully duplex blunt ended and nicked circular molecules. We find that helicase I1 protein is able to initiate on and completely unwind fully duplex DNA molecules without the requirement for a covalently attached 3‘ singlestranded DNA tail. This DNA unwinding activity is dependent upon Mg2+ and ATP and requires that the amount of protein be in excess of that needed to saturate the resulting single-stranded DNA. Unwinding experiments on fully duplex blunt ended DNA with lengthsof 341,849,1625, and 2671 base pairs indicate that unwinding occurs at the same high ratios f helicase IX protein/nucleotide, independent of DNA length (50% unwinding requires -0.6 helicase I1 monomers/ nucleotide in 2.5 mM MgC12, 10% glycerol, pH 7.5, 37 “C). Helicase I1 protein is also able to unwind completely a nicked circular DNA molecule containing 2671 base pairs. At lower but still high molar ratios of helicase I1 protein to DNA, duplex DNA molecules containing a single-stranded (ss) region attached to a 3‘ end of the duplex are preferentially unwound in agreement with the results obtained by S. W. Matson ((1986) J. Biol. Chem. 261, 10169-10175). This preferential unwinding of duplex DNA with an attached 3’ ssDNA most likely reflects the availability of a high affinity site (ssDNAf with the proper orientation for initiation; however, this may not reflect the type of DNA molecule upon which helicase I1 protein initiates DNA unwinding in vivo. The effects of changes in NaCl, NaCH&OO, and MgC12 concentration on the ability of helicase I1 protein to unwind fully duplex DNA and duplex DNA with a 3’ ssDNA tail have also been examined. Although the unwinding of fully duplex and nicked circular DNA molecules reported here occurs at higher heliease I1 protein to DNA ratios than have been previously used in most studies of this protein in vitro, this activity is likely to be relevant to the function of this protein in vivo since very high levels of helicase I1 protein accumulate in E. coli during the SOS response to DNA damage (-2-5 X lo4 copies/cell). The ability of the helicase I1 protein to initiate DNA
Head to head comparison of [F] AV-1451 and [F] THK5351 for tau imaging in Alzheimer’s disease and frontotemporal dementia

Purpose Tau accumulation is a core pathologic change in various neurodegenerative diseases including Alzheimer’s disease and frontotemporal lobar degeneration-tau. Recently, tau positron emission tomography tracers such as [F] AV1451 and [F] THK5351 have been developed to detect tau deposition in vivo. In the present study, we performed a head to head comparison of these two tracers in Alzheimer’s disease and frontotemporal dementia cases and aimed to investigate which tracers are better suited to image tau in these disorders. Methods A cross-sectional study was conducted using a hospital-based sample at a tertiary referral center. We recruited eight participants (two Alzheimer ’s disease, four frontotemporal dementia and two normal controls) who underwent magnetic resonance image, amyloid positron emission tomography with [F]-Florbetaben and tau positron emission tomography with both THK5351 and AV-1451. To measure regional AV1451 and THK5351 uptakes, we used the standardized uptake value ratios by dividing mean activity in target volume of interest by mean activity in the cerebellar hemispheric gray matter. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00259-017-3876-0) contains supplementary material, which is available to authorized users. * Jae Seung Kim jaeskim@amc.seoul. kr * Sang Won Seo sangwonseo@empal.com 1 Department of Neurology, SamsungMedical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Kangnam-ku, Seoul 06351, South Korea 2 Neuroscience Center, Samsung Medical Center, Seoul, South Korea 3 Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea 4 Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, South Korea 5 Department of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea 6 Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA 7 Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA 8 Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea 9 Department of Neurology, Kyung Hee University Hospital, Seoul, South Korea 10 Center of Functional Imaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA 11 Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, South Korea 12 Department of Clinical Research Design & Evaluation, SAIHST, Sungkyunkwan University, Seoul, South Korea Eur J Nucl Med Mol Imaging (2018) 45:432–442 https://doi.org/10.1007/s00259-017-3876-0
DIFFERENT CASTING SOLVENTS ON THEIR PHYSICOCHEMICAL PROPERTIES

Objective: The aim of this work is to investigate the influence of different casting solvents on the physicochemical properties of cetylpyridinium chloride (CPC) chitosan mucoadhesive buccal films. Methods: Screening formulations were prepared by casting solvent technique using organic acids; 1% acetic acid (AA), 1% lactic acid (LA) and inorganic acid; 0.1N HCl (FS1-FS3). Then, 2P 1PX3P 1P factorial design study was done using 2 factors; solvent type (AA, LA, Mixture of 0.1N HCl and LA) and solvent concentration (AA and LA; 1%, 2% and mixture of 0.1N HCl: 1% LA; 2:1, 1:2). Films were evaluated for their physicochemical properties through, mechanical properties, mucoadhesion, in vitro release of CPC and antimicrobial activity. Results: The studied factors showed a significant effect on both mucoadhesion and tensile strength. Film casted from 0.1 N HCl was brittle and did not show any elasticity, so it was used in further studies mixed with LA to improve physicochemical properties of the prepared films. Films casted from LA showed swelling for an initial period of 15 min then no more swelling occurred while swelling of those casted from AA occurred throughout approximately 2 h. A film containing 2:1 HCl: LA (F5) dissolved in both media while 1:2 HCl: LA (F6) showed swelling properties. This was reflected on the in vitro release of CPC in which F5 gave higher % released (DER300 min R54.37%) than the other formulations. Conclusion: Casting solvent was proved to have a significant effect on the physicochemical properties of chitosan CPC mucoadhesive films.
GYMNOMITRION SCHUSTERANUM (GYMNOMITRIACEAE), A NEW SPECIES FROM THE SINO-HIMALAYA GYMNOMITRION SCHUSTERANUM (GYMNOMITRIACEAE) – НОВЫЙ ВИД ИЗ СИНО-ГИМАЛАЙСКОГО РЕГИОНА

A new species of Gymnomitrion, G. schusteranum is described based on specimens from the SinoHimalaya (South-west China and North India). It differs well from other species of the genus by the presence of a pronounced vitta not known in any other Gymnomitrion spp. , as well as its distinctly elongate leaves with unequal lobes, very deep sinus, and revolute margins of sinus and margins of leaves. So far, the species has been found in China in an area with a concentration of other endemic and subendemic Sino-Himalayan liverworts and in West Bengal (India) located ca. 1000 km apart.
High-throughput Analysis of in vivo Protein Stability*□S

Determining the half-life of proteins is critical for an understanding of virtually all cellular processes. Current methods for measuring in vivo protein stability, including large-scale approaches, are limited in their throughput or in their ability to discriminate among small differences in stability. We developed a new method, Stable-seq, which uses a simple genetic selection combined with highthroughput DNA sequencing to assess the in vivo stability of a large number of variants of a protein. The variants are fused to a metabolic enzyme, which here is the yeast Leu2 protein. Plasmids encoding these Leu2 fusion proteins are transformed into yeast, with the resultant fusion proteins accumulating to different levels based on their stability and leading to different doubling times when the yeast are grown in the absence of leucine. Sequencing of an input population of variants of a protein and the population of variants after leucine selection allows the stability of tens of thousands of variants to be scored in parallel. By applying the Stable-seq method to variants of the protein degradation signal Deg1 from the yeast Mat 2 protein, we generated a high-resolution map that reveals the effect of 30,000 mutations on protein stability. We identified mutations that likely affect stability by changing the activity of the degron, by leading to translation from new start codons, or by affecting N-terminal processing. Stableseq should be applicable to other organisms via the use of suitable reporter proteins, as well as to the analysis of complex mixtures of fusion proteins. Molecular & Cellular Proteomics 12: 10.1074/mcp.O113. 031708, 3370– 3378, 2013.
[Re] Training Binary Neural Networks using the Bayesian Learning Rule

Meng, Bachmann, and Khan1 gives a mathematically principled approach to solve the discrete optimization problem that occurs in the case of BinaryNeuralNetworks and claims to give a similar performance on various classification benchmarks such as MNIST, CIFAR-10, and CIFAR100 as compared to their full-precision counterparts, as well as other recent algorithms to train BNNs like PMF and Bop. The paper also claims that the BayesBiNN method has an application in the continual learning domain as it helps in overcoming catastrophic forgetting of the past by using the posterior approximation of the previous task as a prior for the upcoming task. We try to reproduce all the results presented in the original paper by making a separate and independent codebase.
Conserved Function of Myd88 Insensitivity in Zebrafish with a Highly Partially Responsible for Lipopolysaccharide Domain-Containing Adaptor Protein Is A Unique Feature of Toll/IL-1 Receptor

MyD88 and Toll/IL-1R domain-containing adaptor protein (TIRAP) arerequired for the TLR4 response to LPS stimulation in mammals, but the functions of the two adaptors and their involvement in zebraﬁsh insensitivity to LPS remains unknown. We present a functional analysis of zebraﬁsh Myd88 and Tirap and suggest that Myd88 is more important than Tirap for the activation of Tlr-mediated NF- k B, which may be a novel mechanism of Myd88-dependent TLR signaling in teleosts. Zebraﬁsh Tirap lacks the phosphatidylinositol 4,5-bisphosphate binding motif required for human TIRAP location and has leucine at position 233 rather than the conserved proline of human TIRAP, as well as 105 additional aa at the N terminus. Overexpression of zebraﬁsh Tirap in HEK293T cells did not activate NF- k B and IFN- b , but slightly activated NF- k B in carp leukocyte cells. Zebraﬁsh Myd88 alone strongly induced the activation of NF- k B and IFN- b both in HEK293T and carp leukocyte cells. The function of Myd88 was dependent on its cellular location and the proline in the Toll/IL-1R domain. Although zebraﬁsh Tirap was distributed throughout the cell rather than localized to the cytoplasmic membrane, its impaired ability to activate downstream Tlr molecules was unlikely to be related to its location because chimera TIRAP with a human TIRAP N terminus and membrane-binding domain also did not activate NF- k B. However, the mutation of leucine to proline increased the ability of Tirap to activate NF- k B. We suggest that the zebraﬁsh Tirap needs a longer N terminus to perform its function and could be partially responsible for the resistance to LPS in
Advanced Policies Management for the Support of the Administrative Delegation in Federated Systems

—Current identity management systems are experiencing an increasing workload of their administrators in the management of the system policies, mainly derived from the sheer amount of policies they have to create and maintain. This problem is even more relevant in federated environments, where roaming users force them to authenticate and authorize people coming from other institutions. In this context, it is increasingly necessary to adopt new advanced policies for the administrative delegation , which allow balancing this workload among several delegates who will in turn have a much wider knowledge in the application area where these policies will be applied. In this paper, we present an infrastructure that manages the entire life cycle of the administrative delegation policies in federated environments, as well as a way for reducing the complexity in their management for some scenarios, especially on those where the delegates do not have to be experts in the subject area. These delegates will only have to ﬁll in a simple template, which is automatically generated by our infrastructure. Finally, the applicability of the proposed infrastructure is measured with some performance results.
The Innate Immune Response to Infection Induces Erythropoietin-Dependent Replenishment of the Dendritic Cell

Dendritic cells (DC) play a key role in the adaptive immune response due to their ability to present antigens and stimulate naïve T cells. Many bacteria and viruses can efficiently target DC, resulting in impairment of their immunostimulatory function or elimination. Hence, the DC compartment requires replenishment following infection to ensure continued operational readiness of the adaptive immune system. Here, we investigated the molecular and cellular mechanisms of inflammation-induced DC generation. We found that infection with viral and bacterial pathogens as well as Toll-like receptor 9 (TLR9) ligation with CpG-oligodeoxynucleotide (CpG-ODN) expanded an erythropoietin (EPO)dependent TER119CD11a cell population in the spleen that had the capacity to differentiate into TER119CD11c and TER119CD11c cells both in vitro and in vivo. TER119CD11c cells contributed to the conventional DC pool in the spleen and specifically increased in lymph nodes draining the site of local inflammation. Our results reveal a so far undescribed inflammatory EPO-dependent pathway of DC differentiation and establish a mechanistic link between innate immune recognition of potential immunosuppressive pathogens and the maintenance of the DC pool during and after infection. DOI: https://doi.org/10.3389/fimmu.2020. 01627 Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-190898 Journal Article Published Version The following work is licensed under a Creative Commons: Attribution 4.0 International (CC BY 4.0) License. Originally published at: Einwächter, Henrik; Heiseke, Alexander; Schlitzer, Andreas; Gasteiger, Georg; Adler, Heiko; Voehringer, David; Manz, Markus G; Ruzsics, Zsolt; Dölken, Lars; Koszinowski, Ulrich H; Sparwasser, Tim; Reindl, Wolfgang; Jordan, Stefan (2020). The innate immune response to infection induces erythropoietindependent replenishment of the dendritic cell compartment. Frontiers in Immunology, 11:1627. DOI: https://doi.org/10.3389/fimmu.2020. 01627 ORIGINAL RESEARCH published: 31 July 2020 doi: 10.3389/fimmu.2020. 01627 Frontiers in Immunology | www.frontiersin. org 1 July 2020 | Volume 11 | Article 1627 Edited by:
Short Communication Cytochrome P450 mRNA Expression in the Rodent Brain: Species-, Sex-, and Region-Dependent Differences

Cytochrome P450 (P450) enzymes play a critical role in the activation and detoxication of many neurotoxic chemicals. Although research has largely focused on P450-mediatedmetabolism in the liver, emerging evidence suggests that brain P450s influence neurotoxicity by modulating local metabolite levels. As a first step toward better understanding the relative role of brain P450s in determining neurotoxic outcome, we characterized mRNA expression of specific P450 isoforms in the rodent brain. Adult mice (male and female) and rats (male) were treated with vehicle, phenobarbital, or dexamethasone. Transcripts for CYP2B, CYP3A, CYP1A2, and the orphan CYP4X1 and CYP2S1 were quantified in the liver, hippocampus, cortex, and cerebellum by quantitative (real-time) polymerase chain reaction. These P450s were all detected in the liver with the exception of CYP4X1, which was detected in rat but not mouse liver. P450 expression profiles in the brain varied regionally. With the exception of the hippocampus, there were no sex differences in regional brain P450 expression profiles in mice; however, there were marked species differences. In the liver, phenobarbital induced CYP2B expression in both species. Dexamethasone induced hepatic CYP2B and CYP3A in mice but not rats. In contrast, brain P450s did not respond to these classic hepatic P450 inducers. Our findings demonstrate that P450 mRNA expression in the brain varies by region, regional brain P450 profiles vary between species, and their induction varies from that of hepatic P450s. These novel datawill be useful for designingmechanistic studies to examine the relative role of P450-mediated brain metabolism