Miracle-dz/UniFAR-FTUs huggingface dataset:
chondria-derived activator of caspase (Smac) and Cytochrome c from the mitochondria to the cytoplasm, downregulated Survivin and B cell lymphoma-2 (Bcl-2) proteins levels, and upregulated Bcl-2-associated X factor (Bax), apoptotic protease activating factor-1 (Apaf-1), cleaved (c)-caspase-9 and c-ca

Previous studies have indicated that chrysotoxene may be a potential drug used to treat tumors, however the effect of chrysotoxene on hepatoblastoma remains unknown. Therefore, the present study aimed to investigate the cytotoxic effect and elucidate the potential molecular mechanism of chrysotoxene on human hepatoblastoma HepG2 cells. Chrysotoxene (5-40 μg/ml) exhibited cytotoxic activity against HepG2 cells with inhibitory rates of 24.67-84.06% (half maximal inhibitory concentration, 19.64 μg/ml), observed from a Cell Counting Kit‐8 assay. The results of flow cytometry analysis indicated that chrysotoxene (5, 10 or 20 μg/ml) significantly (P<0.01) induced the apoptosis of HepG2 cells with apoptotic rates of 23.14, 35.68 and 55.61% respectively, compared with the control group. The results of western blot analysis indicated that chrysotoxene (5, 10 or 20 μg/ml) significantly (P<0.05) promoted the release of second mitochondria-derived activator of caspase (Smac) and Cytochrome c from the mitochondria to the cytoplasm, downregulated Survivin and B cell lymphoma-2 (Bcl-2) proteins levels, and upregulated Bcl-2-associated X factor (Bax), apoptotic protease activating factor-1 (Apaf-1), cleaved (c)-caspase-9 and c-caspase-3 protein levels in HepG2 cells, compared with the control group. The results of xenograft analysis indicated that chrysotoxene (20 mg/kg) significantly (P<0.01) inhibited the growth of HepG2 cell-induced tumors by regulating the aforementioned apoptotic proteins (Smac, Cytochrome c, Survivin, Bcl-2, Bax, Apaf-1, c-caspase-9 and c-caspase-3), compared with the control group. In conclusion, chrysotoxene induced the apoptosis of HepG2 cells in vitro and in vivo via activation of the mitochondria-mediated apoptotic signaling pathway, suggesting that it may be a potential candidate drug for treating patients with hepatoblastoma.
Graph embedding with rich information through heterogeneous graph

Graph Embedding with rich information through heterogeneous graph Guolei Sun Graph embedding, aiming to learn low-dimensional representations for nodes in graphs, has attracted increasing attention due to its critical application including node classification, link prediction and clustering in social network analysis. Most existing algorithms for graph embedding only rely on the topology information and fail to use the copious information in nodes as well as edges. As a result, their performance for many tasks may not be satisfactory. In this thesis, we proposed a novel and general framework for graph embedding with rich text information (GERI) through constructing a heterogeneous network, in which we integrate node and edge content information with graph topology. Specially, we designed a novel biased random walk to explore the constructed heterogeneous network with the notion of flexible neighborhood. Our sampling strategy can compromise between BFS and DFS local search on heterogeneous graph. To further improve our algorithm, we proposed semi-supervised GERI (SGERI), which learns graph embedding in an discriminative manner through heterogeneous network with label information. The efficacy of our method is demonstrated by extensive comparison experiments with 9 baselines over multi-label and multi-class classification on various datasets including Citeseer, Cora, DBLP and Wiki. It shows that GERI improves the MicroF1 and Macro-F1 of node classification up to 10%, and SGERI improves GERI by 5% in Wiki.
The Market Reaction to the Appointment of Women on Corporate Boards: Evidence from the Italian Listed Companies

During the 2012-2016 period, a large number of Italian companies appointed women directors in their boards, an unusual and unpredictable fact in the Italian industrial system. This paper investigates if any significant reaction has consequently occurred in the Italian stock market. It assumes that a significant market reaction would indicate the investors view the female board members as a strategic value added at the decision making level. To achieve the objective, it was collected a database consisting of 76 appointments of women directors in 67 Italian listed companies over the period 2012-2016 and then it was investigated the stock price performance of those companies in that five years span. The research hypothesis is examined empirically through the event study methodology in order to check the existence of abnormal returns on the appointment of women directors. Findings suggest that investors do not strongly believe that the simple appointment of women directors would have a positive effect on the future performance of firms.
Alternative Communication Program Readapted to a Kaingang Adolescent

The present study aimed to determine whether the use of the Picture Exchange Communication System - PECS favored the communication of an adolescent from the Kaingang indigenous population with intellectual disabilities and language disorders. To verify the effects of the independent variable a single subject design was performed, which involved two phases: baseline and intervention. The system was readapted considering the social, cultural, moral and religious values as well as the habits and customs of that ethnic group. The results showed that the use of the readapted alternative communication system helped to improve the non-verbal communication of the indigenous adolescent and increased her vocabulary, previously considered very restricted and unintelligible.
Learning novel sound patterns

The acquisition of vocabulary represents a key phenomenon in language acquisition, yet it is still poorly understood. Gathercole and colleagues have recently provided a rigorous test of vocabulary knowledge (the nonword repetition test, Gathercole, Willis, Baddeley, & Emslie, 1994) and have adapted the phonological loop part of the working memory model (Baddeley & Hitch, 1974) to explain the nonword repetition findings (e.g. Gathercole & Baddeley, 1989). However, there are two major failings in their explanation: there is no description of how words are learned, and no definition of how the phonological loop interacts with longterm memory. We present an EPAM based computational model which overcomes these problems by combining the phonological loop approach with the EPAM/chunking approach (Feigenbaum & Simon, 1984). Trained on naturalistic phonemically coded speech (from mother’s utterances to 2-3 year old children), the model provides a good match to the nonword repetition data from 2-3 year old children. The model is also able to show the effect on nonword repetition when the model is trained using different sets of input. Implementing the phonological loop within EPAM represents a parsimonious approach to learning novel sound patterns and provides a more precise definition of how vocabulary acquisition may occur.
Testability Metrics for Software Behavioral Models

Design for testability is one of the important research interests in software engineering. It becomes crucial in model-based testing because software behavioral models can be used to construct test sequences to perform conformance testing. However, testability of models has received less attention in the past. A model with high testability is easy to be used to construct effective test sequences, and conformance testing can also be realized easily. To improve testability of software behavioral models, using the formal method, we present five testability metrics: observability, controllability, test constructibility, performability, and error traceability. Then, a case is studied to evaluate the effectiveness of proposed testability metrics. As a result of the case study, models with higher testability can not only be used to generate executable test sequences, but also the size of the constructed test suite is also smaller. Our research will enrich the modeling theory of model-based testing and can improve the application of this test method in industry.
The Metamorphoses of Andragogy

Andragogy and adult education (frequently used synonymously) reflect the involvement of adults in learning. This article presents an overview of the origin and early usage of the term andragogy as it evolved in Europe and in North America. In doing so, a number of issues are identified, the varying uses of the term are described, and the influence of these historical developments on the theory, practice, and identity of present day adult education in Canada are emphasized. The article concludes by making a number of interpretive reflections on the implications this evolution and debate on the concept has for today's field of practice and search for identity. Resume Les termes «education des adultes» et «andragogie», qui refletent habitueullement l'engagement des adultes face a leur propre apprentissage, sont souvent employes comme synonymes. Nous proposons ici un survol des origines et des premiers usages du terme «andragogie» en Europe et en Amerique du Nord. Apres avoir identifie les principaux enjeux et decrit les divers usages du terme, nous aborderons l'influence de cette evolution sur la theorie, la pratique et l'identite des praticiens en education des adultes.
Mapping of Pollution Risk of Surface Waters by Runoff from Watershed: Case of Aghien Lagoon (South of Côte d'Ivoire)

The operating capacity of the Abidjan’s groundwater became insufficient. The deficit in drinking water resources in the District of Abidjan remains the major concern of the decision maker. The Aghien lagoon stands as one of the most interesting alternatives. However, studies show the levels of pollutions of this resource without lighting out on the causes and sources of these pollutions. The present study extends over the entire catchment of the Aghien lagoon which reveals the presence of urban areas and agricultural activity areas. This raises real concerns for the Ivorian authorities. This study suggests making cartography of the risk levels of pollution on the Aghien lagoon by the surface runoff on the watershed to enlighten the decision-makers on the possible measures to be taken for the protection of this resource. It emerges from it that the risk of contamination of the lagoon is very likely. Agricultural and domestic best practices inside the pouring pond are compulsory to fight against the pollutions of this resource.
MARKETING CONTROLLING IN LITHUANIAN FREIGHT TRANSPORT SERVICES ENTERPRISES

Freight transport services increases competitiveness of economics, employment of people, have an influence on creating of GNP. Approximately 12 percent of GNP in EU is created by these services. This forces to investigate this sector. Lithuanian freight transport services enterprises met the growing competition in this market that is increased by enterprises of entire EU. Marketing helps to prepare and take business decisions and plays an important role in the system designed to manage, organize, plan, and control business. Marketing management is the essential obligation to develop the intelligences, manage the competition strategies and create the profitable exchanges. The aims of marketi ng involve systemic and continuous analysis of needs of the main consumer groups, creation and production of product and serving the chosen groups or segments more effectively than competitors. When the aim is reached, enterprises ensure the longterm competitive advantage. Modern marketing control imperative is to find the way for enterprise to react to continual changes of business conditions. Controlling is understood as the conception of systemic management of marketing or separate functional process, as necessary precondition for long-term enterprise’s survival. From the functional point of view marketing management is the activity or process of forming, organizing and implementing of certain decision. An objective of article is to disclose an influence of marketing controlling for enlargement of competitiveness of Lithuanian freight transport enterprises. Methods of investigation are analysis of scien tific works, statistical data, and questionnaire investigation.
Existence and Smoothing Effect of Solutions for the Zakharov Equations

where E is a function from R* xR% to C9 n is a function from R^ xR% to R and 1<^JV<^3. (1. ! )-(! . 3) describe the long wave Langmuir turbulence in a plasma (see [20]). E(t, x) denotes the slowly varying envelope of the highly oscillatory electric field and n(t, x) denotes the deviation of the ion density from its equilibrium. When (1.2) depends on the ion sound speed c, that is, (1.2) is replaced by
An item-oriented recommendation algorithm on cold-start problem

Based on a hybrid algorithm incorporating the heat conduction and probability spreading processes (Proc. Natl. Acad. Sci. U.S.A., 107 (2010) 4511), in this letter, we propose an improved method by introducing an item-oriented function, focusing on solving the dilemma of the recommendation accuracy between the cold and popular items. Differently from previous works, the present algorithm does not require any additional information (e.g., tags). Further experimental results obtained in three real datasets, RYM, Netflix and MovieLens, show that, compared with the original hybrid method, the proposed algorithm significantly enhances the recommendation accuracy of the cold items, while it keeps the recommendation accuracy of the overall and the popular items. This work might shed some light on both understanding and designing effective methods for long-tailed online applications of recommender systems.
Anderson’s theorem for compact operators

It is shown that if A is a compact operator on a Hilbert space with its numerical range W(A) contained in the closed unit disc D and with W(A) intersecting the unit circle at infinitely many points, then W(A) is equal to D. This is an infinite-dimensional analogue of a result of Anderson for finite matrices.
Evaluation of In vitro Antioxidant Activity of Aeschynomene indica

Background: A number of Indian medicinal plants have been used for thousands of years in the traditional system of medicine. Methods: The whole plant of Aeschynomene indica was successively extracted using soxhlet apparatus with solvents as petroleum ether (600C-800C), chloroform, acetone, ethyl acetate and ethanol. The antioxidant activity was studied by using 2,2-diphenyl-p-picryl hydrazyl (DPPH) and free radical scavenging activity by hydrogen peroxide scavenging activity. Results and Discussion: The extracts showed various yields, the ethyl acetate and ethanolic extract yields are 12.64% and 14.08% respectively. The TLC based qualitative analysis showed the presence of flavonoids of and phenolic compounds. The flavonoids from the ethyl acetate and ethanolic extracts have showed good responses towards antioxidant activity comparing with the other remaining extarcts. Conclusion: The IC50 for ethyl acetate and ethanolic exracts were found to be 66.108±0.402 and 108.28±0.621 μg/ml respectively in DPPH method. The IC50 for ethyl acetate and ethanolic extracts were found to be1255.16±0.362 and 177.01±0. 462μg/ml respectively in Hydrogen Peroxide method.
Cross-Ethnic Distribution of Clinically Relevant Cyp2c19 Genotypes and Haplotypes

Study background: Knowledge of the drug metabolism phenotype of a patient is critically important to making an informed choice about therapeutic drug prescription. The objective of this study was to determine the prevalence of common clinically relevant variants of the CYP2C19 gene in Malaysian ethnic groups and in other Asian and Middle Eastern populations, and to predict their metabolic phenotypes. Methods: A total of 1103 subjects from six ancestral origins were genotyped for 16 single nucleotide polymorphic (SNP) markers on the CYP2C19 gene to comprehensively understand their allelic distributions. The expectationmaximisation algorithm was used to analyse the genotype data to estimate the maximum likelihood haplotypes in each sample group and to predict the clinical phenogroups. Results: Of the 16 SNP loci genotyped in the six subpopulations studied, only four SNP markers (rs17885098, rs4986893, rs4244285 and rs3758581) showed polymorphism (minor allele frequency >1.0%). Nearly half of the Indians (55%) and Chinese (48.8%) had at least one copy of the loss-of-function allele. The incidence was relatively lower in Malays (39.3%), Orang Asli (27.3%), Javanese (23.8%) and Saudis (28%). Conclusion: These ethnic groups pose a significant risk of drug sensitivity should they are prescribed regular doses of CYP2C19 substrate.
Video Watermarking Technique using Visual Sensibility and Motion Vector

Together with the rapid growth of Internet service, copyright violation problems, such as unauthorized duplication and alteration of digital materials, have increased considerably (Langelaar et al., 2001). Therefore copyright protection over the digital materials is a very important issue that requires an urgent solution. The watermarking is considered as a viable technique to solve this problem. Until now, numerous watermarking algorithms have been proposed. Most of them are image watermarking algorithms and relatively few of them are related with video sequences. Although image watermarking algorithms can be used to protect the video signal, generally they are not efficient for this purpose, because image watermarking algorithms does not consider neither temporal redundancy of the video signal nor temporal attacks, which are efficient attacks against video watermarking (Swanson et al., 1998). Generally, in the watermarking schemes for copyright protection, the embedded watermark signal must be imperceptible and robust against common attacks, such as lossy compression, cropping, noise contamination and filtering (Wolfgang et al., 1999). In addition, video watermarking algorithms must satisfy the following requirements: a blind detection, high speed process and conservation of video file size. The blind detection means that the watermark detection process does not require original video sequence, and the temporal complexity of watermark detection must not affect video decoding time. Also the file size of video sequence must be similar, before and after watermarking. Due to the redundancy of the video sequence, some attacks such as frame dropping and frame averaging can effectively destroy the embedded watermark, without cause any degradation to the video signal. A design of an efficient video watermarking algorithm must consider this type of attacks (Wolfgang et al., 1999). Basically, video watermarking algorithms can be classified into three categories: watermarking in base band (Wolfgang et al., 1999; Hartung & Girod 1998; Swanson et al., 1998; Kong et al., 2006), watermarking during video coding process (Liu et al., 2004; Zhao et al., 2003; Ueno 2004; Noorkami & Mersereau 2006) and watermarking in coded video sequence (Wang et al., 2004; Biswas et al., 2005; Langelaar & Lagendijk 2002). In the base band technique, the watermarking process is realized in uncompressed video stream, in which almost all image watermarking algorithms can be used, however generally computational complexity for watermark embedding and detection is considerably high for
The study of humic acid foliar application on physiological and biochemical changes in wheat under irrigation withholding at different growth stages

In order to study effect of humic acid (HA) foliar application and limited irrigation, on physiological and biochemical characteristics of wheat an experiment was conducted in research field of Varamin, Iran during 2012 growing season. The experimental design was laid out in a randomized complete block with a split plots arrangement of treatments in three replications. Main plots included four different levels of irrigation (complete irrigation, irrigation withholding at stem elongation stage, irrigation withholding at flowering stage and irrigation withholding at seed setting stage) and three different concentration of HA foliar application (0, 150 and 300) was allocated to subplots. The results showed that irrigation withholding conditions in different growth stages significantly decreased seed yield and total chlorophyll content but by contrast increased electrolyte leakage, antioxidant enzymes activity and lipid and protein peroxidation. It appears that HA act in plants via a specific form of stress that is detected by anti-stress defense systems in plants. These HA applied to plants can protect against water stress in degraded soils. International Journal of Natural Sciences (2015), 5(1) 1-7
Spatiotemporal distribution, abundance, and species-environment relationships of Scyphozoa (Cnidaria) species in Hisarönü, Marmaris, and Fethiye bays (Muğla, Turkey)

This study was undertaken monthly between September 2011 and October 2012 at 10 stations in Hisaronu, Marmaris, and Fethiye bays of Mugla Province with the aim of examining spatiotemporal patterns of distribution, abundances, and environmental associations of Scyphozoa species. Temperature, salinity, dissolved oxygen, and chlorophyll-a values were measured both on the surface and at a depth of 20 m. Scyphozoa species were sampled by observation and counting from a boat and by diving. Mean temperatures of the sampling stations were between 20.08 and 21.26 °C. Salinity and chlorophyll-a concentrations showed typical Mediterranean features in the bays. Three Scyphozoa species, Aurelia aurita (Linnaeus, 1758), Cotylorhiza tuberculata (Macri, 1778), and Cassiopea andromeda Forskal, 1775, were determined in the sampling sites. C. Tuberculata was observed at only one station in Fethiye Bay in August while A. Aurita was found at two stations in Fethiye Bay. It showed a bloom in February with abundance of 152 ind. /100 m3 at the Fethiye 3 station. Distribution of C. Andromeda, which was distributed extensively in the study area, was determined only by scuba diving. This species was observed from April to December with high abundances. Maximum abundances of C. Andromeda were 64 ind. /100 m2 (August) in Hisaronu Bay, 71 ind. /100 m2 (August) in Marmaris Bay, and 64 ind. /100 m2 (June) in Fethiye Bay. Significant relationships were detected between environmental variables and Scyphozoa species. C. Andromeda was positively and significantly correlated with temperature and negatively with dissolved oxygen, while A. Aurita was insignificantly and positively associated with dissolved oxygen and negatively with temperature.