Miracle-dz/UniFAR-FTUs huggingface dataset:
Predictive Biomarkers and Personalized Medicine Impact of MiRSNPs on Survival and Progression in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation

Purpose: A distinctive new group of polymorphisms is constituted by single-nucleotide polymorphism (SNP) inmiRNA processingmachinery inmiRNA precursormolecules and inmiRNA-binding sites, known as miRSNPs. The aim of this study was to ascertain the prognostic impact of six miRSNPs in patients with multiple myeloma and analyze the functional consequences. Experimental Design: One hundred and thirty-seven patients with chemosensitive multiple myeloma (73M/64F) intensified with autologous stem cell transplantation (ASCT) were studied. The median followup was 4 years. The genes and SNPs evaluated in genomic DNA by allelic discrimination were KRT81 (rs3660), AFF1 (rs17703261), FAM179b (rs1053667), and MIR196A2 (rs11614913) for miRNA target genes and TRBP (rs784567) and XPO5 (rs11077) for miRNA biogenesis pathway. Results: Overall survival (OS) was significantly longer in patients with KRT81 rs3660 C/C variant (P 1⁄4 0.037). Functional analysis showed that the presence of C variant in KRT81 30 untranslated region (UTR) is related with a reduction of the protein levels. Moreover, the reduction of KRT81 protein levels by siRNA in multiple myeloma cell lines is related to a decreased proliferation. On the other hand, OS was significantly longer in patientswithC/CorA/C variant inXPO5 rs11077 (P1⁄40.012). Therewas also a significantly longer progression-free survival (PFS) for this SNP (P1⁄4 0.013). This SNP retained its prognostic impact on PFS and OS in a multivariate regression analysis (P 1⁄4 0.028 and P 1⁄4 0.014, respectively). Conclusion: This is the first report that relates miRSNPs with prognosis in multiple myeloma either in a keratin gene (KRT81), target of diverse miRNA multiple myeloma clusters, or in the miRNA biogenesis pathway–related protein exportin-5. Clin Cancer Res; 18(13); 3697–704. 2012 AACR.
Validation of the IASLC/ATS/ERS Lung Adenocarcinoma Classification for Prognosis and Association with EGFR and KRAS Gene Mutations: Analysis of 440 Japanese Patients

Introduction: This study aimed to validate the utility of the new histological classification proposed by the International Association for the Study of Lung Cancer (IASLC), American Thoracic Society (ATS), and European Respiratory Society (ERS) for identifying the prognostic subtypes of adenocarcinomas in Japanese patients; correlations between the classification and the presence of EGFR or KRAS mutation status were also investigated. Methods: We retrospectively reviewed 440 patients with lung adenocarcinoma, who underwent resection. The tumors were classified according to the IASLC/ATS/ERS classification. EGFR and KRAS mutations were detected using the established methods. Results: Five-year disease-free survival rates were: 100% for adenocarcinoma in situ (n = 20) and minimally invasive adenocarcinoma (n = 33), 93.8% for lepidic-predominant adenocarcinoma (n = 36), 88.8% for invasive mucinous adenocarcinoma (n = 10), 66.7% for papillary-predominant adenocarcinoma (n = 179), 69.7% for acinar-predominant adenocarcinoma (n = 61), 43.3% for solid-predominant adencoarcinoma (n = 78), and 0% for micropapillary-predominant adenocarcinoma (n = 19). Multivariate analysis revealed that the new classification was an independent predictor of disease-free survival. EGFR and KRAS mutations were detected in 90 cases (53.9%) and 21 cases (13.3%), respectively; EGFR mutations were significantly associated with adenocarcinoma in situ, minimally invasive adenocarcinoma, lepidic- and papillary-predominant adenocarcinoma, and KRAS mutations adenocarcinomas with mucinous tumor subtypes. Conclusions: We found that the IASLC/ATS/ERS classification identified prognostic histologic subtypes of lung adenocarcinomas among Japanese patients. Histologic subtyping and molecular testing for EGFR and KRAS mutations can help predict patient prognosis and select those who require adjuvant chemotherapy.
Computations of the flow past a still sphere at moderate reynolds numbers using an immersed boundary method

This paper presents an immersed boundary formulation for three-dimensional incompressible flows that uses the momentum equation to calculate the Lagrangian force field indirectly imposing the no-slip condition on solid interfaces. In order to test the performance of this methodology the flow past a sphere for Reynolds numbers up to 1,000 have been calculated. Results are compared with numerical data from other authors and empirical correlations available in the literature. The agreement is found to be very good.
Psychometric qualities of the rand 36-item health survey 1.0: A multidimensional measure of general health status

The reliability and validity of the RAND 36-Item Health Survey 1.0 were investigated in a population sample of 1,063 inhabitants of a Dutch township, all age 17or older. Confirmatory factor analysisonly partly supported the internal structure of the RAND 36-Item Health Survey 1.0. The internal consistency of the instrument was high. Pointing to high convergent validity, a multitrait-multimelhod matrix revealed that the RAND-36 scales showed higher correlations with corresponding scales from other instruments than with noncorresponding scales. However, indicating low discriminant validity, some of these correlations did not exceed the intercorrelations among the RAND-36 scales. Multivariate analysis of variance (MANOVA) showed significant effects of age for physical functioning, role limitations (physical problem), general health perception and pain, and significant effects of education on physical functioning and general health perception. Significant sex differences were found for mental health only. The results of this study on the psychometric properties of the RAND 36-Item Health Survey 1.0 seem promising. There is a need for further studies investigating its factor structure and cross-cultural equivalence.
Intellectual capital reporting between a developing and developed nation

Purpose - This paper examines the patterns of intellectual capital reporting (ICR) of large listed firms in a developing nation, Sri Lanka. The aim of this study is to highlight the differences in ICR practice between developing and developed nations. Design/Methodology/Approach - The paper begins by examining each of the top 30 firms by market capitalization listed on the Colombo stock exchange in 1998/1999 and 1999/2000. Using the content analysis method, it reviews the annual reports of these firms to determine the types of intellectual capital (IC) items reported in Sri Lanka. It then compares these findings with a similar study undertaken in Australia during the same period (Guthrie and Petty, 2000). Findings - ICR differences were identified between Sri Lankan and Australian firms, and it is argued that that these differences can be attributed to economic, social and political factors. The paper highlights the need for a uniform ICR definition and a reporting framework that provides comparative and consistent reporting under the auspices of a regulatory body.Practical Implications - This study highlights important policy issues for Australia, Sri Lanka and other nations. These issues are even more pertinent in the light of the gradual international adoption of the International Financial Reporting Standards (IFRS), formulated by the International Accounting Standards Board (IASB). Originality/Value - Most papers on intellectual capital reporting have focused on firms in developed countries. This study offers insights into comparative reporting practices between a developed and a developing country.
Low error fixed-width two's complement squarer design using Booth-folding technique

This study presents a design method for fixed-width two's complement squarer that receives an n-bit input and produces an n-bit squared product. To efficiently compensate for the truncation error, modified Booth-folding encoder signals are used for the generation of error compensation bias. The truncated bits are divided into two groups depending on their effects on the truncation error. Then, different error compensation methods are applied to each group. By simulations, it is shown that the performance of the proposed method is close to that of the true rounding method and much better than those of other methods. Also, it is shown that the proposed fixed-width two's complement squarers lead to about 34% reduction in area, 35% reduction in power consumption and 10% improvement in speed compared with conventional squarers.
The development of an acoustic probe to measure the thickness of ferro-manganese crusts

This paper describes the development of an acoustic probe designed to perform in-situ measurements of ferro-manganese crust thickness at depths of up to 3000 m. It is planned that this device will operate at low altitudes off the seafloor, mounted onboard an underwater vehicle, and continuously map the crust thickness of regions extending over several kilometres. A prototype probe has been developed together with an algorithm that automatically detects the reflections from the top and bottom surfaces of a layer of crust and measures its thickness. The performance of the system is demonstrated through a series of laboratory experiments carried out using crust samples obtained during the NT09-02 Leg 2 of the R/V Natsushima. First, the ability of the system to measure crust thickness at various ranges to the target is assessed. Next, the effects of pressure are investigated in an experiment where the thicknesses of several crust samples are measured at pressures between 0.1 and 30MPa. Finally, the sub-bottom profiles of a number of crust samples, with and without substrates attached are measured.
www.econstor.eu Optimal Categorization

This paper provides a model of categorizations that are optimal for the purpose of making predictions. In the beginning of each period a subject observes a twodimensional object in one dimension and wants to predict the objects value in the other dimension. The subject partitions the space of objects into categories. She has a data base of objects that were observed in both dimensions in the past. The subject determines what category the new object belongs to on the basis of its rst dimension. She predicts that its value in the second dimension will be equal to the average value among the past observations in the corresponding category. At the end of each period the second dimension is observed. The optimal categorization minimizes the expected prediction error. The main results are driven by a trade-o¤ between (a) decreasing the size of categories in order to enhance category homogeneity, and (b) increasing the size of categories in order to enhance category sample size. Keywords: Categorization; Priors; Prediction; Similarity-Based Reasoning. JEL codes: D83; C72. This paper has bene ted from comments by Ola Andersson, Stefano Demichelis, Tore Ellingsen, Drew Fudenberg, Philippe Jehiel, Topi Miettinen, Robert Östling, Rani Spiegler, Tomasz Strzalecki, and Jörgen Weibull, as well as participants at presentations at the Third Nordic Workshop in Behavioral and Experimental Economics in Copenhagen, SUDSWEc 2009, the Stockholm School of Economics, and the Stony Brook Workshop on Bounded Rationality. Financial support from the Jan Wallander and Tom Hedelius Foundation, and the European Research Council, Grant no. 230251, is gratefully acknowledged. yE-mail: e.mohlin@ucl.ac. uk. Mail: Department of Economics, University College London, Gower Street, London WC1E 6BT, United Kingdom. Telephone: +44 (0)20 7679 5485. Fax: +44 (0)207 916 2775.
Isolation and molecular characterization of the porcine transforming growth factor beta type I receptor ( TGFBR 1 ) gene ☆

The transforming growth factor beta (TGF beta) family is essential for normal growth and development of different organ systems. Here we describe the isolation and molecular characterization of the full-length cDNA and the determination of the genomic DNA sequence of the porcine TGFBR1 gene. The full-length TGFBR1 cDNA 1813 bp contains an open reading frame (ORF) of 1512 bp encoding a TGFBR1 protein of 503 amino acids with a calculated molecular weight (Mw) of 56.4 kDa. A BAC clone harboring the porcine TGFBR1 gene was isolated and sequenced. The results of genomic and cDNA sequences of the porcine TGFBR1 gene demonstrated that it spans a transcription unit of 62,182 bp consisting of nine exons ranging from 125 to 354 bp, and eight introns ranging from 1003 to 29,441 bp. A shorter porcine TGFBR1 isoform resulting from the alternative splicing of exon 7 in porcine TGFBR1 cDNAwas detected. The shorter TGFBR1 isoform contained a 1140 bp ORF encoding 379 amino acids with a calculated Mw of 41.7 kDa. The core promoter of porcine TGFBR1 gene lacks a TATA box but contains GC boxes and CAAT boxes. Multiple transcription initiation and termination sites were identified in untranslated regions (UTR) resulting in the size of 5′-UTR varying from 15 to 62 bp, and the length of 3′-UTR varying from 169 to 228 bp. Quantitative real time PCR results showed that the TGFBR1 transcript was ubiquitously expressed in all tissues examined (i.e. fat, adrenal, brain, spinal cord, muscle, mandibular lymph node, thymus, bone marrow, uterus, spleen, testis, kidney, liver, and ovary). A total of eighty-five gene polymorphisms (77 SNPs and 8 indels) were detected in the porcine TGFBR1 gene by utilizing a panel of DNA from eight diversified pig breeds (Yorkshire, Chinese Meishan, Berkshire, Duroc, Hampshire, Landrace, Large White and Pietrain). The minor allele frequencies of these nucleotide variations varied from 0.13 to 0.5 with an average of 0.26. In addition, seventeen microsatellites were identified throughout the genomic sequence of the porcine TGFBR1 gene. © 2006 Elsevier B.V. All rights reserved.
A hybrid bearing concept for high-speed applications employing aerodynamic gas-bearings and a self-sensing active magnetic damper

Successful application of ultra high-speed electrical drive systems in industrial products is currently limited by lacking high-speed bearing technologies permitting high reliability and long lifetime. Promising bearing technologies for high rotational speeds are contact-less bearing concepts such as active magnetic bearings or gas bearings. While magnetic bearings usually are major electromechanical systems with substantial complexity, gas bearings allow compact realizations with high load capacity and stiffness; however poor dynamic stability has been limiting their use at high rotational speeds. For a new hybrid bearing concept employing an aerodynamic gas bearing for load support, a small-sized self-sensing active magnetic damper is proposed allowing to effectively counteract the self-excited whirl instability of the gas bearing and therewith enabling high speed operation with a minimum of additional complexity and costs.
A Novel Approach to Evaluate the Service Quality by Exploring Social User Contextual Information

With the increase of social media and e-commerce, enormous people prefer to share their experience and rate on review websites. Existing research are mainly focused on personalized recommendation and rating prediction but evaluating the quality of service for recommender system is more important. The proposed approach focuses on service quality evaluation. There are some challenges that do not have enough review information for extracting opinion. In this paper, a Service Quality Evaluation model is proposed to evaluate the service quality. The proposed model can be done in three steps. First step is to calculate the entropy which is utilized in users’ confidence value. Second, to explore the contextual features of user rating in which the spatial-temporal features and sentimental features are reviewed. The final step is to fuse the above two steps into a unified model for calculating the overall confidence value to perform service quality evaluation. The experiments are implemented by using Yelp and Douban dataset.
Primary Care Providers’ Perceptions of Care

The Regional Palliative Care Unit in Ottawa conducted a retrospective study to determine how satisfied patients and families were with the service the Unit offers. Forty-five primary care providers, bereaved from 6 to 12 months, completed the 64-item semistructured telephone interview in a mean time of 20 minutes. The 59 closed-ended questions rated satisfaction levels concerning various aspects of the palliative care service on a 5-point Likert scale. Five open-ended questions elicited family priorities and suggestions for improvement. The major finding was that care was perceived to be highly satisfactory. Unexpected outcomes of the study were the identification by family members of the criteria for a “good death” and families’ perceptions that the Unit offers the best quality of life and death even for those patients who resist admission to the hospice setting.
A study of the genetics of diabetes mellitus.

THERE IS universal agreement that there is a large hereditary component in the causation of diabetes mellitus. In fact Joslin, in the "preamble" to Chapter 3 of the eighth edition of The Treatment of Diabetes Mellitus, makes the statement that "Heredity is the basis of diabetes. " Disagreement arises, however, when an attempt is made to describe the genetic nature of this component. Further on in this same preamble Joslin indicates this uncertainty when he writes, "Would that experts in the genetic field would become interested in this problem. " The preamble is followed by a section written by White and Pincus in which they present an excellent review of the literature as well as of their analysis ol data gathered in Joslin's clinic. As illustrations of the disagreement which exists we may refer to the studies, involving sizable numbers of histories, of some workers who have come to quite different conclusions. Thus Cammidge (1928 and 1934) classified individual family pedigrees according to whether they could more readily be explained as resulting from a dominant or from a recessive gene. He concluded that the disease in those individuals with early onset and severe manifestation tended to be due to a recessive gene and that in those individuals with late onset and a mild expression, the disease tended to be due to a dominant gene (these genes were assumed to be at different loci). Hanhart (1950 and earlier), using the same method of analysis, maintained that all pedigrees may be explained by assuming a single recessive gene. Pincus and White (1933) concluded from their analysis of the pedigrees of 523 diabetic and 153 nondiabetic patients that the data could be satisfactorily explained by assuming that the disease is due to a single recessive gene. However, Levit and Pessikova (1934) concluded from their analysis of 222 pedigrees
Thermal impedance measurement of a self-heating probe

In case of large temperature dependencies of the properties, due to sufficient high voltages and currents the power dissipation in electric devices causes 'virtual' electrical impedances. The reason is the thermal impedance, which is determined by the inside structure and the environmental conditions. For many fields in solid-state circuit design and sensor applications, the actual value of the thermal impedance bears important information about the state of the device and its surroundings. In the paper it is shown, how the actual value of the thermal impedance can be determined directly from the continuously measured virtual electrical impedance
Association Between Corporate Wellness Program Participation and Changes in Health Risks

Objective: To assess the relationship between wellness program participation and employee health risks. Methods: Data from 173,901 health-risk appraisals and wellness program participation records were used to assess changes in seven health risks (blood pressure, body weight, cholesterol level, nutrition, physical inactivity, stress, and tobacco use). Results: Controlling for baseline covariates, high-risk members who completed only a coaching program were significantly more likely to lower five out of seven health risks than were high-risk members in the comparison group. Participation in multiple wellness activities (eg, biometric screening) increased the odds that risks would be reduced. In addition, the number of risk levels that improved was greater than the total that worsened. Conclusions: This study provides evidence that wellness program participation was associated with significant risk reduction, particularly among individuals who participated in more than one program.
Dynamic MR Imaging of the Sexual Arousal Response in Women

The purpose of our studies was to evaluate whether MR imaging could be used to noninvasively observe and measure the sexual arousal response in normal women. We tested the feasibility as well as the reproducibility of rapid, dynamic, serial high-resolution MR imaging of the genital structures during presentation of neutral and sexually stimulating video material. Results show that these MRI techniques can visualize significant changes in clitoral volume during the stimulus segment of the video presentation. Quantitatve measurements made of these changes were robust and reproducible. These studies suggest that MRI techniques may be a useful tool to improve our understanding of the physiology involved with the sexual arousal response in women. These MRI techniques may also prove useful as a surrogate end point marker for testing efficacy of future new treatments for women with sexual arousal disorder.
THE COSMIC INFRARED BACKGROUND: Measurements and Implications ⁄

▪ Abstract The cosmic infrared background records much of the radiant energy released by processes of structure formation that have occurred since the decoupling of matter and radiation following the Big Bang. In the past few years, data from the Cosmic Background Explorer (COBE) mission provided the first measurements of this background, with additional constraints coming from studies of the attenuation of TeV γ-rays. At the same time, there has been rapid progress in resolving a significant fraction of this background with the deep galaxy counts at infrared wavelengths from the Infrared Space Observatory (ISO) instruments and at submillimeter wavelengths from the Submillimeter Common User Bolometer Array (SCUBA) instrument. This article reviews the measurements of the infrared background and sources contributing to it and discusses the implications for past and present cosmic processes.
Crystal structure of hexaprop-2-en-1-yl 4,4′,4′′,4′′′,4′′′′,4′′′′′-[1,3,5,2λ5,4λ5,6λ5-triazatriphosphinine-2,2,4,4,6,6-hexaylhexakis(oxy)]hexabenzoate

In the title compound, C60H54N3O18P3, the central phosphazene ring is essentially planar, with an r.m.s. deviation of the six fitted atoms of 0.068 Å. The P—N bond lengths are within the narrow range 1.575 (2)–1.585 (2) Å, indicating the electrons are delocalized within the ring. The two ethenyl benzoate substituents on each P atom are located up and down with respect to the plane of the central P3N3 ring. The atoms of two terminal propenyl groups are disordered over two sets of sites, with refined site-occupancy ratios of 0.249 (12):0.751 (12) and 0.476 (9):0.524 (9). No intermolecular interactions are observed.
Derivation of the critical angle for Mach reflection for strong shock waves.

In the process of shock-wave reflection at a surface, a transition from regular to Mach reflection occurs when the angle of incidence exceeds a certain critical value. This critical angle, which depends on the Mach number of the propagating shock wave and \ensuremath{\gamma}, the adiabatic exponent of the medium, is well approximated in many experimental situations by its value in the limit of infinite Mach number. Unfortunately, the often-cited critical angle for infinitely strong shock waves is incorrect. We present a short analysis of the process of shock-wave reflection and discuss the condition for infinitely strong shock waves. The exact and approximate solutions for the dependence of the critical angle on the adiabatic exponent of the medium are also compared with the above-mentioned formula.