Miracle-dz/UniFAR-FTUs huggingface dataset:
The influence of glyoxalase 1 gene polymorphism on its expression at different stages of breast cancer in Egyptian women

Aim To assess the association of GLO1 C332C gene polymorphism with breast cancer risk at different stages of the disease and to investigate the effect of this gene polymorphism on its mRNA expression and enzyme activity. Methods GLO1 C332C gene polymorphism was analyzed by PCR-RFLP in 100 healthy controls and 200 patients with breast cancer (100 patients with stage I & II and 100 patients with stage III & IV). GLO1 mRNA expression was measured by real time PCR. Serum GLO1 enzyme activity was measured colorimetrically. Results GLO1 A allele was associated with increased risk of breast cancer [OR (95%CI)= 2.8(1.9-4.1), P < 0.001]. Its frequency was significantly higher among advanced stages of breast cancer compared with localized tumors (OR (95%CI)= 1.9(1.3-2.9), p < 0.001). GLO1 mRNA expression and enzyme activity were significantly higher in breast cancer patients compared to controls and they were much higher in the advanced stages of the disease (P < 0.001). Carriers of AA genotype showed higher GLO1 expression and enzyme activity compared with carriers of CC genotype. Conclusion GLO1 C332C SNP was associated with overexpression of GLO1 mRNA and higher enzyme activity in breast cancer patients suggesting its role in the development of breast cancer and its progression from localized to advanced.
Is there an association between athletic amenorrhea and endothelial cell dysfunction?

PURPOSE To test the hypothesis that young females with athletic amenorrhea and oligomenorrhea show signs of early cardiovascular disease manifested by decreased endothelium-dependent dilation of the brachial artery. METHODS Ten women with athletic amenorrhea (mean +/- SE, age 21.9 +/- 1.2 yr), 11 with oligomenorrhea (age 20.8 +/- 1.1 yr), and 11 age-matched controls (age 20.2 +/- 1.1 yr) were studied. Study subjects were amenorrheic an average of 2.3 (range 0.6-5) yr and oligomenorrheic an average of 6.2 yr. All ran a minimum of 25 miles.wk. They were nonpregnant and free of metabolic disease. Brachial artery flow-mediated dilation (endothelium-dependent) was measured with a noninvasive ultrasound technique in each group. RESULTS Endothelium-dependent brachial artery dilation was reduced in the amenorrheic group (1.08 +/- 0.91%) compared with oligomenorrheic (6.44 +/- 1.3%; P< 0.05) and eumenorrheic (6.38 +/- 1.4%; P< 0.05) groups. CONCLUSION Athletic amenorrhea is associated with reduced endothelium-dependent dilation of the brachial artery. This may predispose to accelerated development of cardiovascular disease.
Brillouin light scattering spectra as local temperature sensors for thermal magnons and acoustic phonons

We demonstrate the use of the micro-Brillouin light scattering (micro-BLS) technique as a local temperature sensor for magnons in a permalloy (Py) thin film and phonons in the glass substrate. When the Py film is uniformly heated, we observe a systematic shift in the frequencies of two thermally excited perpendicular standing spin wave modes. Fitting the temperature dependent magnon spectra allows us to achieve a temperature resolution better than 2.5 K. In addition, we demonstrate that the micro-BLS spectra can be used to measure the local temperature of magnons and the relative temperature shift of phonons across a thermal gradient. Such local temperature sensors are useful for investigating spin caloritronic and thermal transport phenomena in general.
Clinical And Etiological Profile of Children Aged 1 Month To 60 Months Admitted with Microcephaly in Bal Chikitsalaya, Maharana Bhupal Goverment Hospital, RNT Medical College , Udaipur (Rajasthan)

Objective: To study the clinical and etiological profile with the change in brain by neuroimaging (MRI brain) in children with microcephaly aged 1 month to 60 months. Materials and Methods: Study Design – Hospital based prospective study. Children attending Bal Chikitsalaya, Maharana Bhupal Goverment Hospital, RNT Medical College, Udaipur (Rajasthan) were evaluated as per protocol. Z scores of head circumference were calculated using WHO charts and clinical and etiological profile with the change in brain by neuroimaging (MRI brain) of those with microcephaly. Results: 103 children with microcephaly were enrolled in the study. 58 (56.31%) were male and 45 (43.68%) were female. Male to female ratio was 1.29:1. Mean age of children with microcephaly was 19.71±14.79 months. Most children with microcephaly presented with developmental delay 93(90.29%), abnormal tone 75(72.82%), convulsion 29(28.15%), regression of mile stone 13(12.62%), tremor 11(10.68%), visual abnormalities 12(11.65%), hearing abnormalities 10(9.71%) and dysmorphic facies 9(8.74%). The patients were classified according to the final diagnosis into 3 groups; group I: primary microcephaly – 12(11.65%) cases, group II: secondary microcephaly – 88(85.44%) cases and group III: undiagnosed – 3(2.91%). The most frequent MRI findings were cerebral atrophy in 50(48.54%) cases followed by changes suggestive of hypoxic ischemic encephalopathy (HIE) 19(18.94%) cases. Conclusion: Among the microcephaly children admitted in hospital, severe acute malnutrition was the commonest cause followed by cerebral palsy. Cerebral atrophy was most frequent finding on neuroimaging (MRI) followed by changes suggestive of hypoxic ischemic encephalopathy.
Notice of RetractionSmall-World Network Properties of Protein Complexes: Node Centrality and Community Structure

Recently the biological networks have been examined by borrowing the techniques and concepts mainly developed for social networks. In particular protein complexes are found to show small-world behavior. In this study, we show that the set of accessible surface area for amino acids are inversely correlated with the values of vertex betweenness. Under this global trend, specificity for the hot spots in protein interface are further studied. We also show that amino acid residue communities, which are constructed by the iterative elimination of high edge betweenness values in the descending order, are formed around the hot spot residues located in the protein interface area. Experiments with real proteins with known structure verify the small-world behavior of the protein complexes.
Genetic predisposition, environment and cancer incidence: A nationwide twin study in Finland, 1976–1995

Twin studies integrate genetic and environmental (including physical environment and life‐style) information by comparing monozygotic and dizygotic twins for the occurrence of disease. Our objectives were to compare cancer incidence in twins with national rates and to estimate both the probability that co‐twins of affected twins may develop cancer and the importance of genetic predisposition and environment in cancer development. The nationwide record linkage of the Finnish Twin Cohort Study, the Finnish Cancer Registry and the Central Population Register allowed the follow‐up of 12,941 same‐sexed twin pairs for incident primary cancers from 1976 to 1995. Zygosity was determined by use of a validated questionnaire in 1975. Methods included calculation of standardized incidence ratios and concordances and fitting of structural equation models. A total of 1,613 malignant neoplasms occurred in the cohort. The overall cancer incidence among twins resembled that among the general population. Monozygotic co‐twins of affected twins were at 50% higher risk than were dizygotic co‐twins. Based on genetic modeling, inherited genetic factors accounted for 18% (95% confidence interval 4–32%) of the liability in inter‐individual variation in the risk of overall cancer, while non‐genetic factors shared by twins accounted for 7% (0–16%) and unique environmental factors for 75% (65–85%). Our results appear to exclude a contribution greater than one‐third for genetic predisposition in the development of cancer in the general population, thus pointing to the earlier confirmed substantial role of environment. Int. J. Cancer 83:743–749, 1999. © 1999 Wiley‐Liss, Inc.
Optimal Radio-Frequency Power Distribution in a Linear Accelerator Using Beam Energy Measurements

A linear accelerator, including several radio-frequency (RF) stations, can be viewed as one virtual RF station with a certain RF voltage (in amplitude and phase). This paper proposes an optimization scheme that, for a specified total beam energy gain, determines the klystrons output powers as well as the modulators high voltages optimally. The algorithm employs the nonlinear static characteristics curves of klystrons to determine analytically the input RF amplitude of the drive chain. The proposed algorithm facilitates the klystron operating point setting with an automatic procedure for the desired energy gain of a linac.
Solving second order delay differential equations by direct extended two and three point implicit one-step block method

The purpose of this paper is to solve directly the second order delay differential equations (DDEs) using The extended two and extended three point implicit one-step block methods using constant step size. The formulae for the extended two and extended three point implicit one-step block methods will be derived using Lagrange interpolation polynomial. The stability polynomials for the methods are obtained and their regions of absolute stability are discussed. The efficiency of the proposed method is supported by some numerical results.
Comments and further results on "A New Critical Formula and Mathematical Model of Double-Tap Interphase Reactor in a Six-Phase Tap-Changer Diode Rectifier

This paper presents some comments and further results concerning the mathematical model of double-tap interphase reactor (IPR) in a six-phase tap-changer diode rectifier. On the basis of coupling circuit principle and phase-coordinate method, the proposed model, which reduces the mutual inductance coupling completely, describes the double-tap IPR by an admittance matrix containing the information about the connection way and electrical quantities. Some computer simulation and experiments are included to support the theoretical analysis of the model.
Mapping the Gene for Aroma in Rice ( Oryza sativa L.) by Bulk Segregant Analysis via RAPD Markers

The sensory qualities of food such as aroma, taste, and texture are the most important criteria for distinguishing Basmati type rices from non-Basmati types. To map the gene(s) controlling aroma, bulked segregant analysis (BSA) using Random Amplified Polymorphic DNA (RAPD) markers was applied in an F2/F3 population of Basmati 370 (aromatic) and IR36 (non-aromatic). DNA samples from homozygous aromatic and homozygous non-aromatic plants identified on the basis of progeny tests were bulked and used for BSA. A total of 550 random primers were used and the primers, AG8 and AN1, produced polymorphism between aromatic and non-aromatic types. Association of AG8AR, AN1-AR1, and AN1-AR2 with a gene for aroma was determined by surveying F2 individuals. The three RAPD markers AG8-AR, AN1-AR1, and AN1-AR2 were found to be linked to the gene for aroma with a distance of 6.9, 8.9 and 16.4 cM, respectively. Southern analysis with AG8-AR as a probe with 125 F2 individuals confirmed linkage between AG8-AR and the gene for aroma. AG8-AR was mapped on chromosome 8 flanked by two tightly linked markers, RZ617 and RG978, at 2.1 and 1.7 cM distances, respectively, indicating that this gene in Basmati 370 is located on chromosome 8.
Voltage sensitivity based reactive power control on VSC-HVDC in a wind farm connected hybrid multi-infeed HVDC system

With increasing application of both Line Commutated Converter based High Voltage Direct Current (LCC-HVDC) systems and Voltage Source Converter based HVDC (VSC-HVDC) links, a new type of system structure named Hybrid Multi-Infeed HVDC (HMIDC) system is formed in the modern power systems. This paper presents the operation and control method of the wind farm connected HMIDC system. The wind power fluctuation takes large influence to the system voltages. In order to reduce the voltage fluctuation of LCC-HVDC infeed bus caused by the wind power variation, a voltage sensitivity-based reactive power control method is proposed in the paper. According to the calculated sensitivity factors, a reactive power increment is added in the control loop of VSC-HVDC so as to regulate the voltage of the target bus. Dynamic simulations in PSCAD/EMTDC and MATLAB are presented to assess the performance of the proposed control method.
Current Status of Direct Recordings of the Sinus Node Electrogram in Man

Over the past decade the evaluation of human sinus node function and dysfunction was greatly enhanced by clinical electrophysiological studies. ' Electrophysiologic studies also produced more direct evidence for inductive interpretations of electrocardiograms. As in other areas involving human cardiac electrophysiology, notable contributions to our knowledge of the human sinus node were made by Dr. Kenneth Rosen and Dr. Alfred Pick. ^"'^ In keeping with their interest in human sinus node physiology, we will review a recent technical advance in the study of human sinus node electrophysiology— the transvenously recorded sinus node electrogram.
Risk Averse Scheduling by a PEV Aggregator Under Uncertainty

Research on electric power systems has considered the impact of foreseeable plug-in electric vehicle (PEV) penetration on its regulation, planning, and operation. Indeed, detailed treatment of PEV charging is necessary for efficient allocation of resources. It is envisaged that a coordinator of charging schedules, i.e., a PEV aggregator, could exercise some form of load control according to electricity market prices and network charges. In this context, it is important to consider the effects of uncertainty of key input parameters to optimization algorithms for PEV charging schedules. However, the modeling of the PEV aggregator's exposure to profit volatility has received less attention in detail. Hence, this paper develops a methodology to maximize PEV aggregator profits taking decisions in day-ahead and balancing markets while considering risk aversion. Under uncertain market prices and fleet mobility, the proposed two-stage linear stochastic program finds optimal PEV charging schedules at the vehicle level. A case study highlights the effects of including the conditional value-at-risk (CVaR) term in the objective function and calculates two metrics referred to as the expected value of aggregation and flexibility.
Transcription of the Interleukin-1 Receptor-related T1 Gene Is Initiated at Different Promoters in Mast Cells and Fibroblasts (*)

The delayed early serum response gene T1 encodes glycoproteins of the immunoglobulin superfamily with significant sequence similarity to the type 1 interleukin-1 receptor. The T1 gene is transcribed in fibroblasts into an abundant 2.7-kilobase (kb) and a rare 5-kb mRNA in response to proliferation-inducing stimuli. It gives predominantly rise to the longer transcript in the bone marrow of adult mice and in cultured mast cells. Alternative 3′ processing is responsible for the two mRNA forms. The short transcript encodes a secreted protein with marked similarity to the extracellular domain of the interleukin-1 receptor, whereas the long mRNA is translated into a protein with an additional putative transmembrane and an intracellular domain. Here we demonstrate that T1 transcription in mast cells and fibroblasts initiates at two different start sites which are 10.5 kb apart. The alternative first exons are both spliced to exon 2 which contains the translation start site. Northern blot analysis and primer extension experiments revealed that promoter usage is strictly cell type-specific. T1 transcription in mast cells is initiated exclusively at the distal promoter, whereas in fibroblasts both the short and the long T1 mRNA start at the proximal promoter. Two GATA-1 elements were identified in the 5′-flanking region of the mast cell-specific distal exon 1.
Numerical optimization of a TARA-like shielded parabolic reflector

The problem of monochromatic electromagnetic wave diffraction by a perfectly electrically conducting (PEC) surface of rotation located in free space is investigated. The problem is reduced to sets of hypersingular and singular integral equations, which are solved by the method of discrete singularities using interpolation type quadrature formulas. From the solutions of these sets of equations the electric field and the far-zone patterns are obtained. The method presented has guaranteed convergence for a non-axially symmetric primary field. Using this method the Transportable Atmospheric Radar system (TARA) is considered.
Validating Office-Based Screening for Psychosocial Strengths and Difficulties Among Youths in Foster Care

OBJECTIVES: To assess the effectiveness of social-emotional screening in the primary care setting for youths in foster care. METHODS: The setting was a primary care practice for all youth in home-based foster care in 1 county. Subjects were youths, aged 11 to 17 years, and their foster parents; both completed a Strengths and Difficulties Questionnaire at well-child visits. The Strengths and Difficulties Questionnaire is a previously validated 25-item tool that has 5 domains: emotional symptoms; conduct problems; hyperactivity/inattention; peer problems; and prosocial behaviors and an overall total difficulties score. We first compared youth versus parent Strengths and Difficulties Questionnaire scores and then assessed the accuracy of these Strengths and Difficulties Questionnaire scores by comparing them in a subsample of youths (n = 50) with results of home-based structured clinical interviews using the Children's Interview for Psychiatric Syndromes. RESULTS: Of 138 subjects with both youth and parent reports, 78% had prosocial behaviors (strengths), and 70% had 1 or more social-emotional problems. Parents reported significantly more conduct problems (38% vs 16%; P < .0001) and total difficulties (30% vs 16%; P = .002) than did youth. The Strengths and Difficulties Questionnaire had better agreement with the Children's Interview for Psychiatric Syndromes (n = 50) for any Strengths and Difficulties Questionnaire–identified problem for combined youth and foster-parent reports (93%), compared with youth report alone (54%) or parent report alone (71%). CONCLUSIONS: Although most youths in foster care have social-emotional problems, most have strengths as well. Youth and foster-parent perspectives on these problems differ. Systematic social-emotional screening in primary care that includes both youth and parent reports can identify youths who may benefit from services.
Functional genomics in sarcoidosis--reduced or increased apoptosis?

BACKGROUND A variety of studies have stressed the importance of the control of inflammatory cell longevity and the balance of pro-survival and pro-apoptotic signaling pathways. The aim of the study was to investigate the systemic activation of apoptosis pathways using cDNA array technology in patients with acute onset sarcoidosis. METHOD We have performed a comprehensive genomic analysis, applying high-density human GeneChip probe arrays (HGU95A, Affymetrix) for RNA expression profiling from peripheral blood mononuclear cells from patients with acute pulmonary sarcoidosis and matched healthy controls. Twelve patients and 12 controls were assessed, mean age 36 +/- 12 and 33 +/- 10 years respectively. Results focus on apoptosis-related gene products. Group differences were assessed with the Mann-Whitney U-test. RESULTS Seven patients had self-limited disease (all type I sarcoidosis) and 5 progressive disease requiring immunosuppression (all type II or III sarcoidosis). We found 53 of 112 (47%) apoptosis-related gene products dysregulated in sarcoidosis compared to controls. Particular growth factors, especially heparin-binding EGF-like GF, EGF, PDEGF, SISPDGF2 and VEGF, were upregulated in patients consistent with a pro-survival profile. The Bcl-2 family of genes also showed a net pro-survival profile in sarcoidosis patients. In contrast, alterations in the TNF-pathway were compatible with increased apoptosis signals in both, type I and type II/III sarcoidosis patients. Other cell death receptors were equally expressed, as were caspases and p53-associated genes. In contrast to patients with type I-sarcoidosis, patients with progressive type II or III disease showed an upregulation of NFKB and a leak of downregulation of inhibitor of apoptosis 1. CONCLUSION Significant differences in the expression of apoptosis-related genes were found in peripheral blood of patients with acute onset sarcoidosis. Gene expression did not show a definite pattern that was suggestive of pro-survival or proapoptosis. However, the number of genes whose altered expression would be predicted to favour increased survival exceeded that of genes likely to reduce survival. Protein-based confirmation of the differences in the activity of apoptosis-pathways needs to be done in further studies.
Holistic Nursing Care As Perceived By Nurses Working In Wards and Critical Care Units at Menoufiya University Hospital

Holistic nursing care is defined as a philosophy of nursing practice that takes into account total patient care, considering the physical, emotional, social, economical, and spiritual needs of patients, their response to their illnesses, and the effect of illness on patients' abilities to meet self-care needs. Holistic nursing is an attitude, a philosophy, and a way of being. In Egypt, few studies were conducted, and there was a gap of knowledge in the area of holistic nursing care ,especially, in Menoufiya Governorate. Aim: This study aimed at exploring and describing nurses' perception of the meaning of holistic nursing care in wards and critical care units at Menoufiya University Hospital. Subject and Methods: Descriptive cross sectional research design was used in this study. The current study was conducted in Menoufiya University Hospital. One group of sample was included in this study, which incorporated random sample of staff nurses (N =100) working in wards and critical care units in the previously mentioned setting. One standardized questionnaire was used to measure the variable in this study from nurses' point of view. Results: The findings of this study revealed that the great majority (89.7%) of studied nurses in critical care units had high perception regarding holistic nursing care and nearly about three fourth ( 73.8%) of them had high perception in wards. On the other hand, the lowest percentage (10.3%) of studied nurses in critical care units had poor perception and about one fourth (26.2%) of them in wards had poor perception. Conclusion: The majority (80%) of studied nurses had high perception regarding holistic nursing care, while (20%) of them had low perception in both departments. There was difference of statistical significant regarding direct nursing care, infection control, biological aspect of nursing care and management responsibility of nursing care between two departments. However, no differences of statistical significance could be found between the two variables regarding social aspect, activities related to nursing and psychological aspect. Recommendations: Designing and implementing an educational program on the importance of delivering holistic nursing care on patients' outcomes. Further studies are needed with a larger sample size ranging across different governmental and private hospitals in different governorates to generalize the results.
catena-Poly[[[aquasilver(I)]-μ-4,4′-bipyridine-κ2 N:N′] 4-aminobenzoate nitrate hydrate]

In the structure of the title compound, 2[Ag(C10H8N2)(H2O)](C7H6NO2)(NO3)·H2O, the AgI atom is three-coordinated in a T-shaped configuration by two N atoms from two symmetry-related 4,4′-bipyridine (bipy) ligands at short distances and by one water O atom at a longer distance. Each bipy ligand bridges two neighbouring AgI atoms, forming a chain structure extending parallel to [101]. The complete 4-aminobenzoate anion, the nitrate anion and the uncoordinated water molecule are located on mirror planes: together with the coordinated water molecule, they form N—H⋯O, O—H⋯O and O—H⋯N hydrogen bonds, stabilizing the crystal structure.