Miracle-dz/UniFAR-FTUs huggingface dataset:
Research on Identity Mechanism of Large-scale Drug Virtual Screening in Heterogeneous Multicore Environment and SMP Environment

This paper studies the mechanism of ultra-large-scale drug virtual screening in the heterogeneous multicore environment and SMP (Symmetric Multi-Processor) environment. Given the differences caused by different CPUs, we solved the incompatibility of the open-source molecular docking software Autodock Vina on two supercomputer systems in different environments and realized the automatic and intelligent large-scale virtual screening process for small-molecule ligands. At the same time, we propose a processing method of large-scale virtual screening using Autodock Vina in two environments, which makes full use of the dominant computing power of supercomputers to improve the efficiency of large-scale molecular docking and reduce the load of different supercomputer systems facing large-scale molecular docking tasks. Finally, we conduct a virtual screening experiment on the X86 platform supercomputer and the Sunway TaihuLight Supercomputer based on the heterogeneous multicore architecture CPU—SW26010. The experimental results show that our large-scale drug virtual screening method for different CPU environments is effective.
SCALING MULTI-AGENT REINFORCEMENT LEARNING

In multi-agent games, the complexity of the environment can grow exponentially as the number of agents increases, so it is particularly challenging to learn good policies when the agent population is large. In this paper, we introduce Evolutionary Population Curriculum (EPC), a curriculum learning paradigm that scales up MultiAgent Reinforcement Learning (MARL) by progressively increasing the population of training agents in a stage-wise manner. Furthermore, EPC uses an evolutionary approach to fix an objective misalignment issue throughout the curriculum: agents successfully trained in an early stage with a small population are not necessarily the best candidates for adapting to later stages with scaled populations. Concretely, EPC maintains multiple sets of agents in each stage, performs mix-and-match and fine-tuning over these sets and promotes the sets of agents with the best adaptability to the next stage. We implement EPC on a popular MARL algorithm, MADDPG, and empirically show that our approach consistently outperforms baselines by a large margin as the number of agents grows exponentially. The source code and videos can be found at https://sites.google. com/view/epciclr2020/.
Determinants of demand for life insurance: The example of farmers from north-west Poland

Summary: Life insurance is a voluntary and additional element of protection and financial security for the future of insured and financially dependent persons. This safeguard should be of particular importance in the agricultural sector, which is characterized by a high number of accidents at work causing loss of health and death. The decision to buy life insurance depends largely on the economic and social factors characterizing the farm. The purpose of the article is to identify and evaluate the factors determining the purchase of life insurance by persons conducting agricultural activity. Data was collected in the north-west region of Poland using a survey questionnaire. Identification of the factors affecting the purchase of life insurance was made by means of a two-dimensional relationship analysis and logit regression model. The basis of the model was a set of obtained independent variables, based on a survey conducted in 2018 among randomly selected farm owners or managers. The analysis showed that the decision to buy life insurance depended on the sex of the farm owner or manager, the number of people in the farmer’s household, and possession of production insurance. The presented research results indicate that the probability of buying life insurance decreased when the owner or manager of the farm was a man. On the other hand, when the number of people in the farmer’s household increased and agricultural production was insured, the probability of buying life insurance increased. Research results suggest that having life insurance is associated with high awareness of the threats arising from farming activities and is an expression of ensuring financial security for the farmer’s family members in the future. zależała od płci właściciela lub zarządzającego gospodarstwem rolnym, liczby osób w gospodarstwie domowym rolnika oraz posiadania ubezpieczenia produkcji. Wyniki wskazują, że prawdopodobieństwo zakupu ubezpieczenia na życie malało, gdy właścicielem lub zarządzającym gospodarstwem rolnym był mężczyzna. Z kolei gdy liczba osób w gospodarstwie domowym rolnika wzrastała oraz produkcja rolna była ubezpieczona, prawdopodobieństwo zakupu ubezpieczenia na życie wzrastało. Rezultaty badań sugerują, że posiadanie ubezpieczenia na życie wiąże się z dużą świadomością zagrożeń wynikających z prowadzenia działalności rolnej oraz jest wyrazem dbałości o zabezpieczenie finansowe członków rodziny rolnika w przyszłości. na życie, gospodarstwa rolne, rolnicza, bezpieczeństwo finansowe, model logitowy.
Stability and Stabilization of Infinite Delay Systems: A Lyapunov-Based Approach

This article addresses stability and stabilization of infinite delay systems, which are more general but also more challenging to deal with than bounded delay systems. Based on a general model of infinite delay systems and a newly approved key technical lemma, several new Lyapunov theorems for uniform asymptotical stability and exponential stability, respectively, are established. The stability results are more general than existing stability results, and the corresponding conditions are more easily satisfied than existing ones. Therefore, the new stability results are expected to be more widely applicable. These new Lyapunov theorems are then applied to the problems of stabilizing both time-invariant and time-varying linear systems with distributed infinite input delays, and the corresponding stabilizing controllers are developed. Key to obtaining the stabilizing controllers is to construct appropriate Lyapunov functionals for these systems via introduction of a regulation term into the Lyapunov functional. A distinctive advantage of the Lyapunov-based time-domain method proposed in this article over the existing frequency domain method is that the former can be adopted to deal with more general systems, such as time-varying linear systems or even nonlinear systems. Several examples are provided to illustrate the effectiveness of our results.
Design and Fabrication of Semi Automated Solar Powered Sand Sieving Machine

The design and fabrication of semi automated solar powered sand sieving system is done. As sand is used in construction, manufacturing and many industrial purposes, it needs to be filtered and separated from unneeded particles, stones and other large particles before put to use. The rotational motion of motor is converts to reciprocating motion of sieve box by means of Scotch Yoke Mechanism. To pour sand in sieve box a bucket conveyor is designed. Key WordsSieving, Solar Energy, belt conveyor
Transposon mutagenesis identifies cooperating genetic drivers during keratinocyte transformation and cutaneous squamous cell carcinoma progression

The systematic identification of genetic events driving cellular transformation and tumor progression in the absence of a highly recurrent oncogenic driver mutation is a challenge in cutaneous oncology. In cutaneous squamous cell carcinoma (cuSCC), the high UV-induced mutational burden poses a hurdle to achieve a complete molecular landscape of this disease. Here, we utilized the Sleeping Beauty transposon mutagenesis system to statistically define drivers of keratinocyte transformation and cuSCC progression in vivo in the absence of UV-IR, and identified both known tumor suppressor genes and novel oncogenic drivers of cuSCC. Functional analysis confirms an oncogenic role for the ZMIZ genes, and tumor suppressive roles for KMT2C, CREBBP and NCOA2, in the initiation or progression of human cuSCC. Taken together, our in vivo screen demonstrates an extremely heterogeneous genetic landscape of cuSCC initiation and progression, which can be harnessed to better understand skin oncogenic etiology and prioritize therapeutic candidates.
Some Questions and Answers.

a) Your overall GPA is 2.0. b) Your English/Communications GPA is 3.0. c) Your performance in a given area of English/ Communications can be demonstrated (e.g. creative writing, oral communication). d) You have not previously been enrolled at Muskegon Community College, except as a high school guest student. e) You have two letters of recommendation from teachers in the institution last attended: one in English, the other in your chosen performance area
A Flip-Chip Alignment System With the Property of Deviation Self-Correction at the Nanoscale

Alignment system, with large stroke, high accuracy, and deviation automatic correction properties, is really attractive for performing the task of wafer-level flip-chip packaging. The motivation for this work is enabling a common packaging system to run in a manner of deviation automatic correction. To this end, in this article, three parallel kinematic flexure limbs with lever displacement amplifier are designed to construct a 3-RRR (R is revolute) <italic>XY</italic><inline-formula><tex-math notation="LaTeX">$\theta$</tex-math></inline-formula> deviation corrector. After a series of kinematics theoretic analyses and dimension optimizations, the mechanism is evaluated. Given the dynamic coupling linear and angular motion of the corrector are hard to be acquired simultaneously by common commercial displacement sensors, a “coarse-precise” composite visual inspection algorithm is designed to capture the precise motion in <italic>XY</italic><inline-formula><tex-math notation="LaTeX">$\theta$</tex-math></inline-formula> directions at the same time. Then, a series of validation experiments are successfully carried out, including visual inspection test, kinematics characterization, open-loop and closed-loop tracking tests, and flip-chip deviation correction test. The results indicate that the resolution and the absolute positioning accuracy of the developed alignment system are achieved up to 40 nm/10 <inline-formula><tex-math notation="LaTeX">$\mu$</tex-math></inline-formula>rad and 0.3 <inline-formula><tex-math notation="LaTeX">$\mu$</tex-math></inline-formula>m/30 <inline-formula><tex-math notation="LaTeX">$\mu$</tex-math></inline-formula>rad, respectively, and the positioning period under maximum range is kept within two control cycles (0.7 s). Finally, in association with the deviation corrector, the accuracy of the alignment system is improved up to 0.3 <inline-formula><tex-math notation="LaTeX">$\mu$</tex-math></inline-formula>m/0.03 mrad, which proved that the proposed strategy provides an effective solution for the one-step accurate alignment operation of advanced chip packaging.
Physician Interruptions and Workload during Emergency Department Shifts

Interruptions in the Emergency Department (ED) are moderately studied in regard to their impact on physicians’ workload. This study captured interruptions characteristics and measures of workload. Twenty-eight ED physicians were followed during their shifts; interruptions they faced were captured using a validated tablet PC-based tool. At the mid and end of their shift, providers completed a NASA-Task Load Index (TLX) questionnaire and a reaction time task. Descriptive statistics and ANOVA were used to identify relationships between physicians’ interruptions and workload. A total of 2355 interruptions were identified (M =84.1, SD =14.5). The NASA-TLX results showed increase in physicians’ responses for all subscales from mid to end-shifts. Reaction time was higher at end-shift with mean difference of 33.75ms, 95% CI [20.35, 47.13], p < 0.001. At end-shift, there was a statistically significant positive correlation between reaction time and all NASA-TLX subscales. Interruption duration rather than frequency correlated positively with NASA-TLX scores. High/critical interruptions were the least frequent but had longer duration and greater impact on workload. This study provided a unique examination of interruptions over an entire provider shift and identified interruptions as potential causes of increased workload for ED physicians.
The role of properdin in the pathogenesis of murine systemic lupus erythematosus

In systemic lupus erythematosus (SLE), complement-activating immune complexes (ICs) are central to the immunopathogenesis of disease. Their deposition in kidney initiates an inflammatory response resulting in glomerulonephritis. Properdin is the only known positive regulator of complement activation, but its role in SLE disease severity has not been studied yet. Properdin-deficient mice were crossed with MRL/lpr mice on C57Bl/6 background. MRL/lpr mice develop lupus-like disease spontaneously. We derived properdin wildtype, properdin deficient, and properdin heterozygous MRL/lpr mice. Compared to MRL/lpr properdin wildtype mice, MRL/lpr properdin-deficient mice developed significantly less severe disease, had lower serum anti-DNA antibody titre, reduced complement activation, less serum pro-inflammatory cytokines and showed less splenic surface expression of CR2 on B220 positive cells. Parallel analysis of properdin heterozygous MRL/lpr mice revealed a gene dose effect in some measures. There was less serum creatinine in MRL/lpr properdin-deficient mice and colocalising activated C3 fragments and immunoglobulins (ICs) in the mesangium, and less SMA-α and nephrin expression in MRL/lpr properdin-deficient mice compared to MRL/lpr properdin wildtype mice. These findings demonstrate that properdin plays a significant role in the severity of lupus and involvement of kidney in MRL/lpr mice. Because MRL/lpr properdin deficient mice had lower levels of anti-DNA Abs, inflammatory mediators and marker of renal impairment, the study implies that properdin could constitute a novel therapy target.
The Role of Muscular TDP-43 in Neuromuscular Junction Development and Progress of ALS

Amyotrophic lateral sclerosis (ALS) is a fatal disease with fast progression. Patients usually die three to five years after diagnosis. The main characteristics are progressive neurodegeneration, following muscular weakness, and atrophy. The most common cause of death is respiratory muscle failure. Studies have shown that the highlight of the disease is TDP-43 inclusions in neuronal cytoplasm. The symptoms of ALS can be recapitulated in Drosophila melanogaster. The Drosophila‘s ortholog is called TBPH. TBPH knockout flies show locomotion problems, shorter lifespan, and anatomical changes in the neuromuscular junction (NMJ). Our studies aimed to reveal the function of TBPH in muscles. We took advantage of RNA interference and silenced the protein exclusively in muscles. Moreover, we expressed TBPH in tbphΔ23/- fly and tried to understand whether it can rescue reduced mobility, lifespan, and anatomical properties of NMJ. We observed changes in lifespan, motility, and NMJ structure when TBPH was silenced in muscles. Expression of the protein in tbphΔ23/- Drosophila completely recovered the motility of larvae and the level of proteins located in the postsynaptic compartment of NMJ. One of the proteins was Disc large (Dlg), known as scaffold protein involved in NMJ development and maintenance of NMJ structure. Expression of Dlg recovered the phenotype in terms of mobility, lifespan, and NMJ formation. We also demonstrated that the drop of Dlg levels could be seen in neuroblastoma cells and differentiated iPS cells of ALS patients. With that been discovered, not only have we confirmed the relevance of our studies, but we have also opened a new possibility for drug development and treatment. Moreover, with the research, we contributed to a recent hypothesis that muscles can be involved in the onset of ALS.
Global rangeland production systems and livelihoods at threat under climate change and variability

Rangelands are one of the Earth’s major ice-free land cover types. They provide food and support livelihoods for millions of people in addition to delivering important ecosystems services. However, rangelands are at threat from climate change, although the extent and magnitude of the potential impacts are poorly understood. Any declines in vegetation biomass and fluctuations in grazing availability would be of concern for food production and ecosystem integrity and functionality. In this study, we use a global rangeland model in combination with livestock and socio-economic datasets to identify where and to what extent rangeland systems may be at climatic risk. Overall, mean herbaceous biomass is projected to decrease across global rangelands between 2000 and 2050 under RCP 8.5 (−4.7%), while inter- (year-to-year) and intra- (month-to-month) annual variabilities are projected to increase (+21.3% and +8.2%, respectively). These averaged global estimates mask large spatial heterogeneities, with 74% of global rangeland area projected to experience a decline in mean biomass, 64% an increase in inter-annual variability and 54% an increase in intra-annual variability. Half of global rangeland areas are projected to experience simultaneously a decrease in mean biomass and an increase in inter-annual variability—vegetation trends both potentially harmful for livestock production. These regions include notably the Sahel, Australia, Mongolia, China, Uzbekistan and Turkmenistan and support 376 million people and 174 million ruminant Tropical Livestock Units. Additionally, the rangeland communities currently the most vulnerable (here, with the lowest livestock productivities and economic development levels and with the highest projected increases in human population densities) are projected to also experience the most damaging vegetation trends for livestock production. Although the capacity of rangeland systems to adapt is highly complex, analyses such as these generate some of the information required to inform options to facilitate pastoral system mitigation and adaptation strategies under climate change.
Negotiating the Daily Mile Challenge; looking-like a walking break from the classroom

ABSTRACT The purpose of this study was to privilege the views of both pupils and staff in one school’s adoption of the Daily Mile Challenge (DMC). Listening seriously to the views of pupils, who are often the unheard subjects in whole school exercise interventions, the aim was to understand the meanings derived from the requirement to practice the DMC. Data are drawn from non-participant observations, 4 individual teacher interviews and 4 pupil focus groups with a total of 12 students. In order to understand the function of the DMC to its participants, a socio-cultural position was adopted using Dewey’s ends-in-view to analyse the data. This process revealed that complete adaptation of the DMC in name and form created an indeterminate space both for the teachers and pupils; an in-between space of not-classroom, not-break-time, not-running and not-a-mile. This allowed the DMC to be completed when teachers could fit it into their teaching, which was not on a daily or a regular basis. This in-between negotiated space formed the overarching landscape of the DMC. For the teachers, promoting purpose through moving in an orderly fashion was characterised by looking-like the DMC. Within this end-in-view, the pupils had to find an acceptable way to take a moving break. Rather than address unfounded concerns about fitness and risks of obesity, the adoption of the DMC in this school has inadvertently highlighted an important need; for pupils to have an outside break from pressurised classroom performances and to have more opportunities for quality social interactions.
The complete mitochondrial genome of an edible mushroom, Sparassis crispa

Abstract Sparassis crispa, also known as cauliflower mushroom, is a widely used medicinal mushroom in traditional Chinese medicine due to the presence of bioactive substances with pharmacological activity. Here, we report a complete mitochondrial genome sequence of S. crispa consisting of 139,253 bp containing 47 genes including 15 protein-coding genes, 27 transfer RNA, and 5 ribosomal RNA genes obtained from 40.406 Mb genome containing 18,917 predicted contigs using raw data of next-generation sequencing having 85.4% Q30. The overall base composition of S. crispa was 26.47% G-C and 73.53% A-T. The phylogenetic tree based on atp6 sequence data showed its close relationship with Sparassis radicata. The complete mitochondrial genome sequence of S. crispa provides an essential and important DNA molecular data for further phylogenetic and evolutionary analysis of S. crispa.
Oscillation free robust adaptive synchronization of chaotic systems with parametric uncertainties

The complexity of the closed-loop system, short transient response time, and fast synchronization error convergence rates are the three basic parameters that limit hacking in the data encryption and secure the communication systems. This paper addresses the following two challenges: The full-order synchronization (FOS) of two parametrically excited second-order nonlinear pendulum (PENP) chaotic systems with uncertain parameters. The reduced-order synchronization (ROS) between the canonical projection part of an uncertain third-order chaotic Rossler and the uncertain PENP systems. This article designs a new robust adaptive synchronization control (RASC) algorithm to address the above two challenges. The proposed controller achieves the FOS and ROS in a shorter transient time, and the synchronization error signals converge to the origin with faster rates in the presence of bounded unknown state-dependent and time-dependent disturbances. The Lyapunov direct method verifies this convergence behavior. The paper provides parameters updated laws that confirm the convergence of the uncertain parameters to some fixed values. The controller does not cancel the nonlinear terms of the plant; this property of the controller keeps the nonlinear terms in the closed-loop that results in the enhanced complexity of the dynamical system. The proposed RASC strategy is successful in synthesizing oscillation free convergence of the synchronization error signals to the origin for reducing the transient time and guarantees the asymptotic stability at the origin. The simulation results endorse the theoretical findings.
Prevalence and distribution of musculoskeletal disorders in firefighters are influenced by age and length of service

Introduction: The objective of this cross-sectional study is to describe the prevalence and severity of self-reported musculoskeletal disorders (MSDs) in firefighters and how these vary by demographics and length of service (LOS). Methods: A cohort of 294 active-duty firefighters completed a body diagram to indicate the location and pain intensity of their MSK complaints. Where painful sites were indicated, they completed the relevant region-specific self-report disability measure – Neck Disability Index (NDI), Roland Morris Disability Questionnaire (RMDQ), Lower Extremity Functional Scale (LEFS), or the Short Form of Disabilities of the Arm, Shoulder and Hand (QuickDASH) – to quantify severity. Prevalence was determined from the body diagrams and severity from the site-specific self-report questionnaires. Differences in MSK severity based on demographics or LOS were determined using ANOVA. Results: The 294 active-duty firefighters had a mean age of 42.6 (SD 9.7) years and mean duration of service of 15.1.
The complete mitochondrial genome of water deer in Liaoning, China

Abstract We determined the whole mtDNA genome of the water deer (Hydropotes inermis) in Benxi, Liaoning. The total length of the complete mitochondrial genome is 16,355 bp and it consists of 13 protein-coding, 22 tRNA, rRNA genes, and 1 control region (CR). Two overlaps among the 13 protein-coding genes were found: ND4L/ND4 and ND5/ND6. The CR is 928 bp in length. The nucleotide composition is 30.52% A, % 33.38 T, 22.77% G, and 13.32% C.