Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of Blood Parameters Alteration Following Low-dose Radiation Induced by Myocardial Perfusion Imaging

Introduction: With increasing the usage of myocardial perfusion imaging (MPI) for the diagnosis of ischemic heart disease, we aimed to evaluate the side effects of low-dose radiation induced by this technique on blood elements, especially proteins and liver function factors. Material and Methods: 40 eligible patients (Mean age: 54.62±10.35, 22 female and 18 male), who had referred to the nuclear medicine department for MPI from May till August 2014, were enrolled in the study. A blood sample was taken from each patient just before and 24 hours after the injection of 740Mbq of Tecnetium-99m Methoxy isobutyl isonitrile (99mTc-MIBI) in the rest phase of the MPI in a reference medical laboratory; blood tests included total protein (TP), albumin (Alb), globulin (Glo), aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), direct bilirubin (D.Bili), total bilirubin (T.Bili), serum iron (SI), total iron bounding capacity (TIBC), Albumin globulin ratioA/G ratio), and complete blood count (CBC). Results: Injection of 740Mbq99mTc-MIBI caused a significant increase in serum levels of AST (p= 0.001), ALT (p= 0.001), SI (p= 0.030), TIBC (p= 0.003) and A/G Ratio (p= 0.020). However, following radiotracer injection, a significant decrease was noted in the serum levels of TP (p= 0.002), Alb (p= 0.014), Glo(p= 0.002), ALP (p= 0.001), D.Bili (p= 0.003) and T.Bili (p= 0.000). Conclusion: Due to increased usage of MPI, our data highlights the importance of monitoring the clinical and paraclinical effects of the procedure on vital organs and physiological pathways to reduce their adverse effects.
Prevalence of human papillomavirus types in North and Central regions of Mexico

Abstract Human papillomavirus (HPV) is a DNA virus linked to mucosal and cutaneous carcinogenesis. More than 200 different HPV types exist. We carried out a transversal study to investigate the prevalence of HPV types in two regions of Mexico. A total of 724 genital and non-genital samples from women (F) and men (M) were studied; 241 (33%) from North-Eastern (NE) and 483 (66%) from South-Central (SC) Mexico. The overall prevalence was 87%. In genital lesions from females, the NE group showed a prevalence of HPV types 16 (37%), 6 (13%), 59 (6%), 11, 18 and 66 (5.4% each); and the SC group showed types 6 (17%), 16 (15%), 11 (14.5%), 18 (12%) and 53 (6%). In the genital lesions from males, NE group showed types 16 (38%), 6 (21%), 11 (13%) and 59 plus 31 (7.5%) and the SC group showed types 6 (25%), 11 (22%), 18 (17%) and 16 (11.5%). When the two regions were compared, a higher prevalence of low-risk HPV 6 and 11 was found in the SC region and of high-risk HPV 59, 31 and 66 (the latter can also be present in benign lesions) in the NE region. Our findings complement efforts to understand HPV demographics as a prerequisite to guide and assess the impact of preventive interventions.
Hemin Induces the Activation of NLRP3 Inflammasome in N9 Microglial Cells.

BACKGROUND Hemin is an important sterile component that induces a neuroinflammatory response after intracerebral hemorrhage, in which NLRP3 inflammasome activation has also proved to be involved. Although microglial activation acts as a key contributor in the neuroinflammatory response, the relationship between hemin and NLRP3 in microglia remains poorly understood. OBJECTIVE To investigate whether or not hemin regulates microglia-mediated secondary injury through activating the NLRP3/caspase-1 signaling pathway in microglia. METHODS In this study, N9 microglial cells were treated with hemin, and subsequently used to detect the production of caspase-1 p10 and NLRP3 inflammasome assembly. An ELISA was subsequently performed to measure the secretion of IL-1β. RESULTS It was found that the production of activated caspase-1 was dose- and time-dependent with regards to hemin. Moreover, hemin was observed to be capable of inducing the assembly of the NLRP3 inflammasome without any increase in IL-1β. Similarly, the supernatant of hemin-treated primary microglial cells did not increase in IL-1β secretion. Furthermore, hemin-induced NLRP3 inflammasome activation did not significantly affect pyroptosis. CONCLUSION Hemin is a potential sterile danger signal molecule that can induce inflammasome activation without directly mediating inflammation damage on microglia.
The decoupled extended Kalman filter for dynamic exponential-family factorization models

We specialize the decoupled extended Kalman filter (DEKF) for online parameter learning in factorization models, including factorization machines, matrix and tensor factorization, and illustrate the effectiveness of the approach through simulations. Learning model parameters through the DEKF makes factorization models more broadly useful by allowing for more flexible observations through the entire exponential family, modeling parameter drift, and producing parameter uncertainty estimates that can enable explore/exploit and other applications. We use a more general dynamics of the parameters than the standard DEKF, allowing parameter drift while encouraging reasonable values. We also present an alternate derivation of the regular extended Kalman filter and DEKF that connects these methods to natural gradient methods, and suggests a similarly decoupled version of the iterated extended Kalman filter.
Latest Results From the Hybrid Illinois Device for Research and Applications (HIDRA)

The Hybrid Illinois Device for Research and Applications (HIDRA) is a toroidal fusion device at the University of Illinois at Urbana–Champaign, Urbana, IL, USA. HIDRA is the former WEGA stellarator that was operated at the Max Planck Institut für Plasmaphysik, Greifswald, Germany. The machine is a five-period, <inline-formula> <tex-math notation="LaTeX">$l=2, m=5$ </tex-math></inline-formula> stellarator, with major radius <inline-formula> <tex-math notation="LaTeX">$R_{0}=0.72$ </tex-math></inline-formula> m, and minor radius <inline-formula> <tex-math notation="LaTeX">$a=0.19$ </tex-math></inline-formula> m. Initial heating is achieved with 2.45-GHz electron cyclotron resonance heating and an on-axis magnetic field of <inline-formula> <tex-math notation="LaTeX">$B_{0}=0.087$ </tex-math></inline-formula> T that can go as high as <inline-formula> <tex-math notation="LaTeX">$B_{0}=0.5$ </tex-math></inline-formula> T. HIDRA has the ability to operate as both a stellarator and a tokamak, initially operating in the stellarator mode. The focus of research on HIDRA will be doing dedicated studies on plasma-material interactions (PMIs) using the wealth of knowledge and experience at the Center for Plasma Material Interactions, Urbana, IL, USA. In early 2016, the first experiments were performed on HIDRA. This paper presents some of the first results obtained from the machine such as initial magnetic fields’ measurements and plasma discharges. It also shows the development of the control system being currently implemented and introduces HIDRA-materials analysis tool, the <italic>in situ</italic> PMI facility that will be mounted on HIDRA in the near future to further enhance the diagnostics and material testing experiments meant to be conducted on the machine.
NEW HEAVY-ION CANCER TREATMENT FACILITY AT HIMAC

Based on more than ten years of experience with HIMAC, we have proposed a new treatment facility for the further development of therapy with HIMAC. The new facility, as an extension of the existing one, has been designed, and the related R&D work has been carried out. The new treatment-facility project was approved at December 2007.
Writing of Long Period Fiber Gratings Using CO2 Laser Radiation

The development of optical fiber gratings (OFGs) had made significant advances both in terms of research and development of optical communications and sensors. OFGs are intrinsic devices that allow modulate the properties of light propagation within the fiber. Grating structures are comparatively simple and in its most basic form, consist on a periodic modula‐ tion of the properties of an optical fiber (usually the refraction index of the core). Its application as a sensing element is advantageous because of the intrinsic characteristics of the fiber sensors, such as remote sensing, electromagnetic immunity, weight and compactness, and capability for real time sensing and low cost [1].
A genetic algorithm for the optimization of admission scheduling strategy in hospitals

Decisions for admission scheduling in hospitals are a class of optimization problems constrained by many factors. Instead of scheduling the admission of patients directly, this paper proposes a genetic algorithm (GA) designed for the optimization of a long-term admission strategy for the ophthalmology department in hospitals. For the optimization of admission strategy, we devise a coding scheme of strategies and define the objective functions for two objectives: efficiency and fairness. The proposed algorithm utilizes historical data of the hospital for evaluation of chromosomes. Experiments are conducted on several cases, and the strategy optimized by the proposed GA is compared with the first come first serve (FCFS) strategy and the greedy strategy. Experimental results show that strategies optimized by the proposed algorithm outperform FCFS and the greedy strategy.
Wirkungsvolle ergotherapeutische Methoden zur Behandlung von graphomotorischen Schwierigkeiten bei Kindern im Alter von vier bis zwölf Jahren mit Fokus auf die visuelle Wahrnehmung

Two studies were conducted to investigate the effect of a task-specific self-instruction intervention to improve handwriting ability of children with poor handwriting quality in schools for regular education (Study 1) and children with poor handwriting quality in schools for special education (Study 2). Study 1 showed that children with poor handwriting quality who received handwriting intervention on an individual basis for three months improved on average more on quality of writing than control children without handwriting problems who did not receive intervention. In contrast, the control group improved more in speed of writing after the intervention period. At an individual level, three out of the seven children with poor handwriting quality before intervention were not classified as such anymore after the intervention period. Study 2 showed that after six months of intervention in a group setting children with poor handwriting quality improved their quality of writing more so than children with poor handwriting quality who had not received intervention. On speed of handwriting no significant group differences emerged. We conclude that the task-oriented self-instruction method applied in this study seems to improve especially the quality of handwriting, not speed, of children initially identified as having poor handwriting quality. 2003 Elsevier B.V. All rights reserved. Corresponding author. Tel. : +31-30-2534601; fax: +31-30-2537731. E-mail address: m.jongmans@fss.uu. nl (M.J. Jongmans). 0167-9457/$ see front matter 2003 Elsevier B.V. All rights reserved. doi:10.1016/j.humov. 2003.09. 009 Human Movement Science 22 (2003) 549–566 www.elsevier. com/locate/humov PsycINFO classification: 2330; 3250
An investigation of primary school teachers' problem-solving beliefs and practices in mathematics classrooms

Aims. Problem-solving approaches to teaching mathematics have been recommended in curriculum documents for some time but there is evidence to suggest that there has been limited classroom implementation both in Australia as well as overseas. This investigation explored the level of implementation of mathematical problem solving in primary classrooms in NSW. Teachers' beliefs about the role of problem solving in learning mathematics as well as their classroom practices were also investigated.
Hyperspectral Data Analysis and Visualisation

Electro-Optical (EO) imaging sensors are widely used for a range of tasks, e.g. for Target Acquisition (TA: detection, recognition and identification of (military) relevant objects) or visual search. These tasks can be performed by a human observer, by an algorithm (Automatic Target Recognition) or by both (Aided Target Recognition). In the past decades, the development of night vision devices in the thermal infrared and image intensifying systems has greatly extended the applicability of EO systems. Despite of these rapid developments, the current generation of sensors has important limitations. Until now, operational thermal imagers are sensitive to IR (infrared) radiation from a single spectral band in the Long Wave (8-14 μm, LWIR) or Mid Wave (3-5 μm, MWIR) infrared region. These so-called broad band sensors basically produce a monochrome (i.e. a black-and-white pan-chromatic) image that deviates considerably from a normal daylight view, and is based on temperature contrasts in a scene. With these systems, the distinction between real targets and decoys, r between military and civilian targets is often difficult to make. Also, camouflaged targets or targets hat are hidden deep in the woods are difficult to detect. Recognizing different objects and materials may be difficult. Examples of misinterpretations when using an Image Intensifier system are grass that looks like snow, or trees that look like bushes, when seen from a helicopter. These misinterpretations may lead to disorientation (loss of Situational Awareness) or to a (fatal) wrong distance estimation. Currently, multi-band and hyperspectral imaging sensors in the thermal infrared are under development. Traditionally hyperspectral imagers were developed for satellites with applications ranging from monitoring the environment, climate analysis, detection of pollution and fires. These systems also promise significant improvements in military task performance. With these new systems, targets may be distinguished not only on the basis of differences in radiation magnitude, but also on differences in spectral properties.
A Model of Events based on a A Model of Events based on a Foundational

Die Arbeitsberichte aus dem Fachbereich Informatik dienen der Darstellung vorlaufiger Ergebnisse, die in der Regel noch fur spatere Veroffentlichungen uberarbeitet werden. Die Autoren sind deshalb fur kritische Hinweise dankbar. Alle Rechte vorbehalten, insbesondere die der Ubersetzung, des Nachdruckes, des Vortrags, der Entnahme von Abbildungen und Tabellen – auch bei nur auszugsweiser Verwertung.
List of tables. List of figures

Medical specialties provide essential information about which providers have the skills needed to carry out key procedures or make critical judgments. They are useful for training and staffing and provide confidence to patients that their providers have the experience needed to address their problems. This work evaluates how machine learning classifiers can be trained on treatment histories to recognize medical specialties. Such classifiers can be used to evaluate staffing and workflows and have applications to safety and security. We focus on treatment histories that consist of the patient diagnoses. We find that some specialties, such as a urologist, can be learned with good precision and recall, while other specialties, such as anesthesiology, are less easily recognized. We call the former diagnosis specialties and explore four machine learning techniques for them, which we compare to a naive baseline based on the diagnoses most commonly treated by specialists in a training set. We find that these techniques can improve substantially on the baseline and that the best technique, which uses Latent Dirichlet Allocation (LDA), provides precision and recall above 80% for many diagnosis specialties based on a study with one year of chart accesses and discharge diagnoses from a major hospital. Furthermore, we explored several data mining techniques to discover valid but unlisted diagnosis specialties. We present the diagnosis specialty discoveries and their associated attributes that corroborate the discoveries.
Higher n–6:n–3 Fatty Acid Intake Is Associated with Decreased Cardiometabolic Risk Factors in a Racially Diverse Sample of Children

Abstract Background Accumulating evidence implicates diet quality in childhood as playing a significant role in adult cardiometabolic health. Polyunsaturated fatty acids (PUFAs) of the n–6 (ω-6) and n–3 (ω-3) series contribute unique protective effects against cardiometabolic disease. As such, the ratio between n–6 and n–3 PUFAs is a dietary metric of interest in the early life span, although an optimum intake ratio has yet to be determined. Objective This cross-sectional study assesses relations between the ratio of total n–6:n–3 PUFA intake and cardiometabolic risk factors in a racially diverse sample of children (n = 191) from the Admixture Mapping of Ethnic and Racial Insulin Complex Outcomes (AMERICO) study. Methods Outcome measures included waist circumference, lipid concentrations, fasting glucose, and two 24-h dietary recalls from boys and girls aged 7–12 y who self-reported as European American (n = 81), African American (n = 55), or Hispanic American (n = 55). Linear regression analyses were used to assess associations between predictors of interest and outcomes after adjusting for covariates. Results PUFA intake reflected in the n–6:n–3 ratio was inversely associated with concentrations of total and LDL cholesterol [β ± SE: −0.359 ± 0.107 (P = 0.001) and −0.189 ± 0.069 (P = 0.007), respectively]. Exploratory analyses showed that the intake of total n–6 PUFAs was not significantly predictive of any cardiometabolic risk factor assessed, whereas total n–3 PUFA intake was positively associated with concentrations of HDL cholesterol (β ± SE: 0.114 ± 0.042; P = 0.007). Conclusions Results suggest that the effect of n–6 and n–3 PUFA intake reflected in the ratio may be largely driven by n–3 PUFAs in reducing 2 lipid cardiometabolic risk factors among this multiethnic cohort of children. Until an ideal intake ratio is determined, nutritional counseling should focus on meeting recommended levels of both n–3 and n–6 PUFAs in order to establish beneficial childhood dietary patterns that may positively influence adult cardiometabolic health.
Metastasis-free Survival - A New End Point in Prostate Cancer Trials.

Transitioning to Clinical Metastases The FDA’s approval of apalutamide for use in nonmetastatic castration-resistant prostate cancer (nmCRPC) was based on an improvement in metastasis-free survival. It was the first drug approval for nmCRPC and the first use of this primary end point to support drug approval.
Interactive Curve Constrained Functional Maps

Functional maps have gained popularity as a versatile framework for representing intrinsic correspondence between 3D shapes using algebraic machinery. A key ingredient for this framework is the ability to find pairs of corresponding functions (typically, feature descriptors) across the shapes. This is a challenging problem on its own, and when the shapes are strongly non‐isometric, nearly impossible to solve automatically. In this paper, we use feature curve correspondences to provide flexible abstractions of semantically similar parts of non‐isometric shapes. We design a user interface implementing an interactive process for constructing shape correspondence, allowing the user to update the functional map at interactive rates by introducing feature curve correspondences. We add feature curve preservation constraints to the functional map framework and propose an efficient numerical method to optimize the map with immediate feedback. Experimental results show that our approach establishes correspondences between geometrically diverse shapes with just a few clicks.
Objectively Measured Changes in Physical Activity and Sedentary Behavior in Cardiac Rehabilitation: A PROSPECTIVE COHORT STUDY

Purpose: Physical inactivity and sedentary behavior (SB) are independent risk factors for cardiovascular disease and all-cause mortality. No studies appear to have investigated whether SB in cardiac rehabilitation (CR) participants changes over time. The aim of this study was to objectively assess physical activity (PA) and SB of CR participants over 6 wks. Methods: Using a prospective cohort study design, 72 CR participants, age = 64.2 ± 9.6 y (mean ± standard deviation [SD]) (79% male), wore an ActiGraph ActiSleep accelerometer for 7 consecutive days at the beginning and end of a 6-wk program to assess daily minutes of moderate-to-vigorous PA (MVPA) and SB (<100 counts/min). Other outcomes collected were self-reported MVPA (Active Australia Survey) and SB (Past-Day Adults' Sedentary Time Questionnaire), body mass index, waist-to-hip ratio, lipid profile, blood glucose level, quality of life (MacNew), exercise capacity (6-min walk test), anxiety and depression (Hospital Anxiety and Depression Scale). Results: Time spent in MVPA and SB did not change over 6 wks. However, exercise capacity and light-intensity PA significantly improved (P < .01). On average, participants spent 11.8 ± 1.1 hr daily in SB, with 9.5 ± 14.7 min daily in MVPA at the end of the CR program. There was some evidence that males and females had different movement patterns. Conclusions: Levels of PA are low and SB is high in CR participants despite changes in exercise capacity over 6 wks. Participants in CR did increase their PA but only in the light-intensity range. Alternative approaches in CR should be considered to encourage participants to move more and sit less.
AMPHIBIAN CHYTRID FUNGUS (BATRACHOCHYTRIUM DENDROBATIDIS) IN COASTAL AND MONTANE CALIFORNIA, USA ANURANS

We found amphibian chytrid fungus (Bd = Batrachochytrium dendrobatidis) to be widespread within a coastal watershed at Point Reyes National Seashore, California and within two high elevation watersheds at Yosemite National Park, California. Bd was associated with all six species that we sampled (Bufo boreas, B. canorus, Pseudacris regilla, Rana draytonii, R. sierrae, and Lithobates catesbeianus). For those species sampled at 10 or more sites within a watershed, the percentage of Bd-positive sites varied from a low of 20.7% for P. regilla at one Yosemite watershed to a high of 79.6% for P. regilla at the Olema watershed at Point Reyes. At Olema, the percent of Bd-positive water bodies declined each year of our study (2005-2007). Because P. regilla was the only species found in all watersheds, we used that species to evaluate habitat variables related to the sites where P. regilla was Bd-positive. At Olema, significant variables were year, length of shoreline (perimeter), percentage cover of rooted vegetation, and water depth. At the two Yosemite watersheds, water depth, water temperature, and silt/mud were the most important covariates, though the importance of these three factors differed between the two watersheds. The presence of Bd in species that are not declining suggests that some of the amphibians in our study were innately resistant to Bd, or had developed resistance after Bd became established.