Miracle-dz/UniFAR-FTUs huggingface dataset:
The TTYH3/MK5 Positive Feedback Loop regulates Tumor Progression via GSK3-β/β-catenin signaling in HCC

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide, and identification of novel targets is necessary for its diagnosis and treatment. This study aimed to investigate the biological function and clinical significance of tweety homolog 3 (TTYH3) in HCC. TTYH3 overexpression promoted cell proliferation, migration, and invasion and inhibited HCCM3 and Hep3B cell apoptosis. TTYH3 promoted tumor formation and metastasis in vivo. TTYH3 upregulated calcium influx and intracellular chloride concentration, thereby promoting cellular migration and regulating epithelial-mesenchymal transition-related protein expression. The interaction between TTYH3 and MK5 was identified through co-immunoprecipitation assays and protein docking. TTYH3 promoted the expression of MK5, which then activated the GSK3β/β-catenin signaling pathway. MK5 knockdown attenuated the activation of GSK3β/β-catenin signaling by TTYH3. TTYH3 expression was regulated in a positive feedback manner. In clinical HCC samples, TTYH3 was upregulated in the HCC tissues compared to nontumor tissues. Furthermore, high TTYH3 expression was significantly correlated with poor patient survival. The CpG islands were hypomethylated in the promoter region of TTYH3 in HCC tissues. In conclusion, we identified TTYH3 regulates tumor development and progression via MK5/GSK3-β/β-catenin signaling in HCC and promotes itself expression in a positive feedback loop.
Do observed sex ratios in a turtle community in northern Indiana vary over 35 years (1979–2014)?

—Anthropogenic changes to the environment (e.g., climate change, roads, habitat alteration) can cause sex ratios in freshwater turtles to differ from the expected 1:1 ratio. We examined long-term trends in the sex ratios of five species of freshwater turtles in Dewart Lake in northern Indiana from 1979 to 2014. None of the species ( Chelydra serpentina , Chrysemys picta , Graptemys geographica , Trachemys scripta elegans , and Sternotherus odoratus ) showed significant temporal trends in sex ratio, and indeed they all showed remarkably consistent sex ratios (i.e., proportion of males). Overall, the mean proportion of males did not differ significantly from 0.5 in C. picta , G. geographica , or T. s. elegans , while both C. serpentina and S. odoratus had significantly male-biased sex ratios. Our failure to observe any changes in the sex ratios over the course of our study does not preclude an impact of the anthropogenic factors on these species of turtles, but suggests that they are not influencing sex ratios in a systematic way in Dewart Lake.
Acoustic full-waveform tomography of realistic 2D synthetic seismic elastic data

Advanced computing facilities accelerate the research in highly computational seismic imaging techniques (full-waveform tomography (FWT) and migration) that play a vital role in hydrocarbon exploration. We have carried out a synthetic study to understand the practical intricacies of FWT for its successful application to field seismic data by choosing different strategies. The results show that the high-resolution features, which are missing from the conventional traveltime tomography, are well imaged by the FWT. Further, frequency overlapping is more suitable than discrete frequencies without overlapping for FWT in obtaining reasonable results from multiscale imaging.
Key Components of Social Skills Training

Definitional Issues: What Are Social Skills? In the past, other authors have defined social skills as “interpersonal responses . that allow the child to adapt to the environment through verbal or non-verbal communication” (Mateson and Mateson, 2007) or “socially acceptable learned behaviors that enable a person to interact with others in ways that elicit positive responses and assist in avoiding negative responses” (Bellini & Peters, 2008). What both these definitions have in common is the description of a social context (i.e., that these behaviors happen with other people around), and that the behaviors are desirable (i.e., “adaptive,” “elicit positive responses”). Perhaps more simply put,
A preliminary study on marine top predators inhabiting Gökçeada Island, the North Aegean Sea

Marine top predators, such as sharks, teleosts and cetaceans, are great indicators of a healthy ecosystem. The primary goal of this paper is to fill the knowledge gaps on top predators in Gökçeada Island located in the North Aegean Sea. Data on marine top predators were collected through Local Ecological Knowledge. Besides, visual and acoustic field surveys were carried out in the summer and autumn of 2019 and winter of 2020. According to the results of the current study, a total of 464 individuals were reported via social media platforms and questionnaires applied to stakeholders as fishermen, divers and harpooners. Delphinus delphis Linnaeus, 1758, Tursiops truncatus (Montagu, 1821) and Physeter macrocephalus Linnaeus, 1758 were detected during approximately 15 hours of acoustic recording. The records of Carcharodon carcharias (Linnaeus, 1758) , Isurus oxyrinchus Rafinesque, 1810 , Xiphias gladius Linnaeus, 1758 , Thunnus thynnus (Linnaeus, 1758), D. delphis, Stenella coeruleoalba (Meyen, 1833), T. truncatus , Grampus griseus (Cuvier, 1812), P. macrocephalus, Ziphius cavirostris (Cuvier, 1823), Monachus monachus (Hermann, 1779) were listed in this study. A total of 358 individuals of X. gladius and T. thynnus were reported between the years 2017-2020, being the most abundant top predators in the area.
Camel Treebank: An Open Multi-genre Arabic Dependency Treebank

We present the Camel Treebank (CAMELTB), a 188K word open-source dependency treebank of Modern Standard and Classical Arabic. CAMELTB 1.0 includes 13 sub-corpora comprising selections of texts from pre-Islamic poetry to social media online commentaries, and covering a range of genres from religious and philosophical texts to news, novels, and student essays. The texts are all publicly available (out of copyright, creative commons, or under open licenses). The texts were morphologically tokenized and syntactically parsed automatically, and then manually corrected by a team of trained annotators. The annotations follow the guidelines of the Columbia Arabic Treebank (CATiB) dependency representation. We discuss our annotation process and guideline extensions, and we present some initial observations on lexical and syntactic differences among the annotated sub-corpora. This corpus will be publicly available to support and encourage research on Arabic NLP in general and on new, previously unexplored genres that are of interest to a wider spectrum of researchers, from historical linguistics and digital humanities to computer-assisted language pedagogy.
CellsTh1 Differentiation by Nonobese Diabetic T Either IL-2 or IL-12 Is Sufficient to Direct

Th cell differentiation from naive precursors is a tightly controlled process; the most critical differentiation factor is the action of the driving cytokine: IL-12 for Th1 development, IL-4 for Th2 development. We found that CD4 (cid:1) T cells from nonobese diabetic mice spontaneously differentiate into IFN- (cid:2) -producing Th1 cells in response to polyclonal TCR stimulation in the absence of IL-12 and IFN- (cid:2) . Instead, IL-2 was necessary and sufﬁcient to direct T cell differentiation to the Th1 lineage by nonobese diabetic CD4 (cid:1) T cells. Its ability to direct Th1 differentiation of both naive and memory CD4 (cid:1) T cells was clearly uncoupled from its ability to stimulate cell division. Autocrine IL-2-driven Th1 differentiation of nonobese diabetic T cells may represent a genetic liability that favors development of IFN- (cid:2) -producing autoreactive T cells. The Journal of Immunology, 2003, 170: 735–740. Abs
AGN FEEDBACK AT Z ∼ 2 AND THE MUTUAL EVOLUTION OF ACTIVE AND INACTIVE GALAXIES

The relationships between galaxies of intermediate stellar mass and moderate luminosity active galactic nuclei (AGNs) at 1 < z < 3 are investigated with the Galaxy Mass Assembly ultra-deep Spectroscopic Survey (GMASS) sample complemented with public data in the GOODS-South ﬁeld. Using X-ray data, hidden AGNs are identiﬁed in unsuspected star-forming galaxies with no apparent signs of non-stellar activity. In the color–mass plane, two parallel trends emerge during the ∼ 2 Gyr between the average redshifts z ∼ 2 . 2 and z ∼ 1 . 3: while the red sequence becomes signiﬁcantly more populated by ellipticals, the majority of AGNs with L (2 − 10 keV) > 10 42 . 3 erg s − 1 disappear from the blue cloud/green valley where they were hosted predominantly by star-forming systems with disk and irregular morphologies. These results are even clearer when the rest-frame colors are corrected for dust reddening. At z ∼ 2 . 2, the ultraviolet spectra of active galaxies (including two Type 1 AGNs) show possible gas outﬂows with velocities up to about -500 km s − 1 that are not observed neither in inactive systems at the same redshift, nor at lower redshifts. Such outﬂows indicate the presence of gas that can move faster than the escape velocities of active galaxies. These results suggest that feedback from moderately luminous AGNs (log L X < 44 . 5 erg s − 1 ) played a key role at z & 2 by contributing to outﬂows capable of ejecting part of the interstellar medium and leading to a rapid decrease in the star formation in host galaxies with stellar masses 10 < log( M /M ⊙ ) < 11.
MOLECULAR PHYLOGENETIC ANALYSIS OF UNIOVULATE

Parsimony and Bayesian analyses of plastid rbcL and trnL-F DNA sequence data of the pantropical family Euphorbiaceae sensu stricto (s.s.) are presented. Sampling includes representatives of all three subfamilies (Acalyphoideae, Crotonoideae, and Euphorbioideae), 35 of 37 tribes and 179 of the 247 genera of uniovulate Euphorbiaceae sensu lato (s.l.). Euphorbiaceae s.s. were recovered as a monophyletic group with no new adjustments in circumscription. Two clades containing taxa previously placed in Acalyphoideae are found to be successive sisters to all other Euphorbiaceae s.s. and are proposed here at subfamilial rank as Peroideae and Cheilosoideae. The remainder of the family fall into seven major lineages including Erismantheae and Acalyphoideae s.s. (parts of Acalyphoideae), Adenoclineae s.l. , Gelonieae, articulated crotonoids and inaperturate crotonoids (parts of Crotonoideae), and Euphorbioideae. Potential synapomorphies and biogeographical trends are suggested for these clades. Acalyphoideae s.s. , inaperturate crotonoids, and Euphorbioideae tribe Hippomaneae each have two major subclades that represent novel groupings without apparent morphological synapomorphies. Two subfamilies, 14 tribes, and 10 genera were found to be paraor polyphyletic. Noteworthy among these, Omphaleae are embedded in Adenoclineae, Hureae 1 Pachystromateae in Hippomaneae, Ditta in Tetrorchidium, and Sapium s.s. in Stillingia.
Function of Ngro/ Genes in the Evolution of Nicotiana glauca: Conservation of the Function of NgORF13 and NgORF14 after Ancient Infection by an Agrobacterium rhizogenes-LXkt Ancestor

Ngro/ genes are thought to have resulted from horizontal gene transfer from an Agrobacterium rhizogenes-like ancestor early in the evolution of the genus Nicotiana. Four Ngro/ genes (Ngro/B, Ngro/C, NgORF13 and NgORF14) have been found in the genome of N. glauca, but their functions are not yet known. We have investigated the properties of Ngro/ genes and shown that some of them are able to function in tobacco plants. Transgenic analysis revealed that NgORF13 promotes RirolB-me-diated adventitious root induction on tobacco leaf segments. NgORF14 also promoted the Riro/B-mediated root induction, but the intensity of this promoting effect was weak. These promoting functions of NgORF13 and NgORF14 have much the same efficiency as those of the corresponding genes of A. rhizogenes, RiORF13 and RiORF14, respectively. Overexpression of NgORF13, under control of the cauliflower mosaic virus 35S promoter (P 35 s), provoked morphological abnormalities in transgenic tobacco plants. Transgenic plants that harbored the P 3 ss-NgORF13 had rounded leaves and stout flowers resulting from suppression of the longitudinal growth of leaf and floral leaves such as sepals, petals, stamens and carpels. These results suggest that NgORF13 and NgORF14 in the genome of N. glauca have conserved functional sequences since their original integration event by an A. rhizogenes-\ike ancestor.
and test of the

Previous research has predominantly focused on negative effects of music exposure by demonstrating that listening to antisocial music increases aggression and aggression-related variables. The present research tests the idea that listening to prosocial (relative to neutral) music decreases aggressive outcomes. In fact, five studies revealed that prosocial music exposure decreased aggressive cognition, affect, and behavior. Mediational analyses showed that the effect of music condition on aggressive behavior was accounted for by differences in aggressive affect. Implications of these results for the predictive validity of the General Learning Model (Buckley & Anderson, 2006) for the effects of media exposure on social tendencies are discussed. important ways. Study 4 assessed the effects of prosocial exposure on indirect, relational aggression (Crick & Grotpeter, toward a target who did not the participant. Study 5 examines the effects of music exposure on direct, physical aggression toward a target person (administering hot chili sauce) who had insulted the participant. on antisocial outcomes. On a more general level, by documenting (a) media effects on aggressive behavior and (b) the mediating path from media exposure to action, the present research offers the first comprehensive test of the effects of prosocial media exposure on aggression and aggression-related variables.
EFFECT OF SUPPLEMENTING SOM MEDICINAL HERBS AND PLANTS ON THE PERFORMANCE OF LACTATING GOATS: 1- PRODUCTIVE AND REPRODUCTIVE PERFORMANCE.

This study aimed to evaluate supplementation effects of four types of medicinal herbs on productive and reproductive performance of Zaraibi goat does. Thirty fife pregnant does (38.2±0.58 kg LBW, 3 years old) during the last two months of pregnancy were allocated to fife treatment groups (7 in each). All groups were fed similar basal diet consisted of concentrate feed mixture (CFM), berseem hay and rice straw. Does in the 1 st group was fed on basal diet without supplementation (control), while CFM in diets of the 2 nd , 3 rd , 4 th , and 5 th group was supplemented with 100 mg/kg LBW, of ginger powder (GIN), curcumin or turmeric powder (TUR), oregano leaves crushed (ORE) or crushed Nigella sativa seeds (NSS). Live body weight of dams were recorded during pre- and post-partum, milk yield and composition were recorded during suckling period. Postpartum 1 st oestrus was detected; litter size and viability of kids were calculated at birth and weaning. Blood components of does were estimated at weaning. Results showed insignificant differences in LBW of dams during pre-partum period. LBW of does increased (P<0.05) in all treated groups as compared to control, being higher (P<0.05) in ORE, TUR and NSS than in GIN group, respectively. Similar trend was found after kidding, but the difference in LBW of does between GIN and control group was not significant. Total litter weight at birth/doe was higher (P<0.05) affected by medicinal herbs treatment. Activity of ALP and AST increased (P<0.05) in GIN, while activity of ALP, AST and ALT decreased (P<0.05) in ORE group. In conclusion, dietary supplementation with NSS had beneficial effects on growth and milk production, while supplementation with ginger yielded the best reproductive performance of Zaraibi goat does.
DEVELOPMENT AND EVALUATION OF EMULGEL FOR WOUND HEALING ACTIVITY

The study was designed with the aim to evaluate metformin and atorvastatin for its wound Healing activity.Two different formulations of Metformin emulgel and atorvastatin emulgel were formulated using Design expert 9.0 . The drugs were first screened for its solubility in various surfactant, co-surfactants and oils. The solvents having maximum solubility was selected for the microemulsion formulation. LAS (Linear Alkyl benzene Sulfonate), Span 80 and Almond oil were selected as Surfactant, co-surfactant and oil respectively. Microemulsion formulation was optimized using ternary phase diagram, globule size and percent transmittance. F1 and F43 formulations were optimized for Metformin and atorvastatin respectively. This optimized micro-emulsion was than utilize to form Emulgel. Lecithin and Sepineo P 600 was used as gelling agent for the formation of Emulgel. Emulgel was then evaluated for spreadability, viscosity and drug release.The optimized formula contained 3% sepineo P600 and 1% penetration enhancer i.e., Oleic acid. This optimized gel with good spreadability was further assessed for in-vivo wound healing activity using excision model. The results showed better wound healing for metformin gel compared to standard Betadine Ointment and Atorvastatin emulgel. Hence study concludes Metformin gel can be a promising therapy to treat Diabetic foot ulcer.
Opto-Electronics Review Symmetrical and asymmetrical imino-naphthalimides in perovskite solar cells

In perovskite solar cells, series of symmetrical and asymmetrical imino-naphthalimides were tested as hole-transporting materials. The compounds exhibited high thermal stability at the temperature of the beginning of thermal decomposition above 300 °C. Obtained iminonaphthalimides were electrochemically active and their adequate energy levels confirm the application possibility in the perovskite solar cells. Imino-naphthalimides were absorbed with the maximum wavelength in the range from 331 nm to 411 nm and emitted light from the blue spectral region in a chloroform solution. The presented materials were tested in the perovskite solar cells devices with a construction of FTO/b-TiO 2 /m-TiO 2 /perovskite/ HTM/Au. For comparison, the reference perovskite cells were also performed (without hole-transporting materials layer). Of all the proposed materials tested as hole-transporting materials, the bis-(imino-naphthalimide) containing in core the triphenylamine structure showed a power conversion efficiency at 1.10% with a short-circuit current at 1.86 mA and an open-circuit voltage at 581 mV.
Numerical Simulations for Coupled Pair of Diffusion Equations by MLPG Method

This paper deals with the development of a new method for solution of initial-boundary value problems governed by a couple of nonlinear diffusion equations occurring in the theory of self-organization in non-equilibrium systems. The time dependence is treated by linear interpolation using the finite difference method and the semi-discrete partial differential equations are considered in a weak sense by using the local integral equation method with approximating 2-d spatial variations of the field variables by the Moving Least Squares. The evaluation techniques are discussed and the applicability of the presented method is demonstrated on two illustrative examples with exact solutions being used as benchmark solutions.
Radio-loud Quasars above Redshift 4: Very Long Baseline Interferometry (VLBI) Imaging of an Extended Sample

High-redshift radio sources provide plentiful opportunities for studying the formation and evolution of early galaxies and supermassive black holes. However, the number of known radio-loud active galactic nuclei (AGN) above redshift 4 is rather limited. At high redshifts, it appears that blazars, with relativistically beamed jets pointing toward the observer, are in the majority compared to the radio-loud sources with jets misaligned with respect to the line of sight. To find more of these misaligned AGN, milliarcsecond-scale imaging studies carried out with very long baseline interferometry (VLBI) are needed, as they allow us to distinguish between compact-core–jet radio sources and those with more extended emission. Previous high-resolution VLBI studies revealed that some of the radio sources among blazar candidates in fact show unbeamed radio emission on milliarcsecond scales. The most accurate optical coordinates determined with the Gaia astrometric space mission are also useful in the classification process. Here, we report on dual-frequency imaging observations of 13 high-redshift (4 < z < 4.5) quasars at 1.7 and 5 GHz with the European VLBI Network. This sample increases the number of z > 4 radio sources for which VLBI observations are available by about a quarter. Using structural and physical properties, such as radio morphology, spectral index, variability, brightness temperature, as well as optical coordinates, we identified six blazars and six misaligned radio AGNs, with the remaining one tentatively identified as blazar.
Sunscreen Factor Formulation and Test of Gel Preparations of 70% Ethanol Extract on Arabica Coffee Leaf (Coffea arabica L.)

Arabica coffee leaf extract (Coffea arabica L.) contains phenolic and flavonoid compounds that are potentially active as sunscreen because it might absorb UV (Ultra Violet) A and UV B rays. It is well-known that UV rays exposure causes a negative effect to skin, yet is possible to be avoided by applying sunscreen. This research aims to test the effect of arabica coffee leaf extract on formulation of gel preparations and to discover how its concentration affects the amount of gel preparations’ sunscreen factor. There were 4 formulas with different extract concentrations whose characteristics were tested chemically, physically, and they were tested to measure its SPF number. From this test, it was discovered that the gel was qualified and it was plastic thixotropic flow. The measurement of SPF number proposed that F1 could not be categorized as protector because it was only 0.6 while F2, F3, and F4 showed that these formulas could be categorized as minimum protector. The samples were also tested statistically by using One Way ANOVA and Tukey HSD test. The result of the ANOVA test showed the number of sig 0.000 < 0.05 which meant all four formulas were significantly different. The research concludes that the extract of arabica coffee leaf might affect the formulation of gel preparations and its extract concentration might affect SPF number on gel preparations.
The role of philanthropy in reducing impact of disaster on economies of ASEAN-9

This study aims to determine the mediating effect of economic growth on the relationship between disaster and unemployment in the ASEAN-9 economies during the 2000-2020 period. It also attempts to examine the moderating role of religious philanthropy in reducing the impacts of disasters on economic growth and unemployment in the ASEAN-9. By using a combination of path analysis and panel moderated regression model, the study found that disasters have adversely affected economic growth and caused an increase in the employment rate. In addition, philanthropy is found to have a negative moderating role in the effects of disaster on economic growth and unemployment. The findings showed a significant role of philanthropy in reducing the impacts of disasters on economic growth and unemployment in ASEAN-9. Our findings provide an important benchmark for the formulation of government policies to mitigate disaster risks on economic problems through the enhancement of religious philanthropic institutions.