Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Graphic Health Warning Labels Placed on the ENDS Device on Young Adult Users’ Experience, Exposure and Intention to Use: A Pilot Study

ABSTRACT This proof-of-concept study aims to evaluate the effect of placing graphic health warning labels (GHWLs) on the ENDS device on users’ experience, puffing patterns, harm perception, nicotine exposure, and intention to quit or use in the future. JUUL users (n = 26, age 18–24 years; 69% male; 85% Hispanic) were recruited to complete two 60 minutes ad libitum sessions that differed by GHWL on the device (GHWL vs. no-GHWL control) in an experimental clinical lab study. Compared to the control session, using JUUL with GHWL on the device was significantly associated with reduced positive experiences such as pleasure, product liking, and user satisfaction (p-value < 0.05 for all). Also, after exposure to GHWL, participants were less interested in using the same product again (p-value = 0.007), even if it was the only product available on the market compared to control (p-value = 0.03). Trends toward reduced puffing behavior and nicotine boost were also noted during the GHWL, compared to control sessions. This pilot study shows that placing GHWL on the ENDS device may be an effective and promising strategy to reduce ENDS use among young people.
Mindfulness as a mediator between trauma exposure and mental health outcomes: Results from the National Health and Resilience in Veterans Study.

OBJECTIVE Exposure to traumatic life events is associated with increased risk of posttraumatic stress disorder (PTSD) and other mental health problems such as suicidal ideation (SI), alcohol use disorder (AUD), and decreased quality of life (QOL). Mindfulness, which involves attending to the present moment, may help individuals cope with traumatic events by increasing acceptance of trauma-related experiences and decreasing trauma-related negative affect and avoidance of trauma reminders. The current study evaluated whether mindful attention to the present moment mediated the association between number of lifetime traumas and mental health. METHOD The sample consisted of 1,268 trauma-exposed U.S. veterans who participated in the National Health and Resilience in Veterans Study, a nationally representative study of U.S. veterans. On average, the sample was 60.6 years of age (SD = 15.2, range = 20-94), predominantly male (89.8%), Caucasian (75.0%), and noncombat veterans (59.2%). RESULTS Path analyses revealed that mindfulness partially mediated the relation between number of lifetime traumas and PTSD symptoms (β = -.55), AUD (β = -.17), and QOL (β = .38), and fully mediated the relation between number of lifetime traumas and SI (β = -.36). CONCLUSIONS The relationship between lifetime trauma burden and various mental health issues of relevance to U.S. veterans may be mediated by mindfulness, or the ability to pay attention to the present moment. Interventions that bolster mindfulness may help mitigate the negative impact of cumulative traumas in this population. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
Immigration Status, Ethnicity, and Long-term Outcomes Following Ischemic Stroke

Objective To assess the association between immigration status and ethnicity and the outcomes of mortality and vascular event recurrence following ischemic stroke in Ontario, Canada. Methods We conducted a retrospective cohort study using linked administrative and clinical registry–based data from 2002 to 2018 and compared hazards of all-cause mortality and vascular event recurrence in immigrants and long-term residents using inverse probability of treatment weighting accounting for age, sex, income, and comorbidities. We stratified analyses by age (≤75 and >75 years) and used interaction terms to evaluate whether the association between immigration status and outcomes varied with age or ethnicity. Results We followed 31,918 adult patients, of whom 2,740 (8.6%) were immigrants, for a median follow-up of 5 years. Immigrants had lower mortality than long-term residents (46.1% vs 64.5%), which was attenuated after adjustment (hazard ratio [HR] 0.94; 95% confidence interval [CI] 0.88–1.00), but persisted in those younger than 75 years (HR 0.82; 0.74–0.91). Compared to their respective ethnic long-term resident counterparts, the adjusted hazard of death was higher in South Asian immigrants, similar in Chinese immigrants, and lower in other immigrants (p value for interaction = 0.003). The adjusted hazard of vascular event recurrence (HR 1.01; 0.92–1.11) was similar in immigrants and long-term residents, and this observation persisted across all age and ethnic groups. Conclusions Long-term mortality following ischemic stroke is lower in immigrants than in long-term residents, but is similar after adjustment for baseline characteristics, and it is modified by age at the time of stroke and by ethnicity.
Rational design of a lysosome-targeting and near-infrared absorbing Ru(II)-BODIPY conjugate for photodynamic therapy.

A Ru(ii)-BODIPY conjugate has been rationally designed and exhibits an intense absorption in the NIR region to boost lysosome-targeted PDT in vitro and in vivo. The advantages of Ru(ii) and BODIPY were successfully instilled into the conjugate to yield highly effective PDT efficacy against malignant melanoma A375 cells (PI = 3448) and A375 mice xenografts.
Synthesis of Strontium Barium Niobate Thin Films through Metal Alkoxide

Highly oriented Sr 0.5 Ba 0.5 Nb 2 O 6 (SBN50) thin films have been prepared using a sol-gel method. A homogeneous and stable strontium barium niobate (Sr 1-x Ba x Nb 2 O 6 , SBN) precursor solution could be prepared via the reaction control of metal alkoxides. The SBN precursor was stabilized by the coordination of the 2-ethoxyethoxy group to metals. SBN thin films on MgO(100) crystallized to a mixture of orthorhombic and tetragonal phase at 700°C and then transformed completely to the tetragonal phase of tungsten bronze at 1000°C. Two crystal lattice planes of SBN were intergrown at an orientation of 18.5° on MgO(100). SBN50 thin films on Pt(100)/MgO(100) substrates exhibited the P-E hysteresis.
Service providers’ perspectives on hoarding management in the community in Singapore

INTRODUCTION Hoarding behaviours are often associated with high disability, psychiatric comorbidity, care burden and adverse health outcomes in people with hoarding behaviours and their families, often requiring multidisciplinary and collaborative task forces with diverse specialisations to mitigate the situation. However, such task forces can face structural challenges in areas such as leadership, purpose, funding and membership. In such instances, stakeholder or service provider mapping and analysis can help in gaining a deeper understanding of the processes and challenges on the ground.
Colon cancer cell differentiation by sodium butyrate modulates metabolic plasticity of Caco-2 cells via alteration of phosphotransfer network

The ability of butyrate to promote differentiation of cancer cells has important implication for colorectal cancer (CRC) prevention and therapy. In this study, we examined the effect of sodium butyrate (NaBT) on the energy metabolism of colon adenocarcinoma Caco-2 cells coupled with their differentiation. NaBT increased the activity of alkaline phosphatase indicating differentiation of Caco-2 cells. Changes in the expression of pluripotency-associated markers OCT4, NANOG and SOX2 were characterized during the induced differentiation at mRNA level along with the measures that allowed distinguishing the expression of different transcript variants. The functional activity of mitochondria was studied by high-resolution respirometry. Glycolytic pathway and phosphotransfer network were analyzed using enzymatical assays. The treatment of Caco-2 cells with NaBT increased production of ATP by oxidative phosphorylation, enhanced mitochondrial spare respiratory capacity and caused rearrangement of the cellular phosphotransfer networks. The flexibility of phosphotransfer networks depended on the availability of glutamine, but not glucose in the cell growth medium. These changes were accompanied by suppressed cell proliferation and altered gene expression of the main pluripotency-associated transcription factors. This study supports the view that modulating cell metabolism through NaBT can be an effective strategy for treating CRC. Our data indicate a close relationship between the phosphotransfer performance and metabolic plasticity of CRC, which is associated with the cell differentiation state.
Creating self-assembled arrays of mono-oxo (MoO3)1 species on TiO2(101) via deposition and decomposition of (MoO3)n oligomers

Significance The design and synthesis of hierarchically ordered oxides remains a critical challenge in material science and catalysis. Here, we demonstrate that well-ordered homotopic arrays of mono-oxo (MoO3)1 can be easily prepared on anatase TiO2(101) via the deposition of (MoO3)n oligomers. As revealed by our combined experiential and theoretical studies, the oligomers spontaneously decompose and self-assemble into chemically identical and thermally stable monomers. The oligomer decomposition is permitted at room temperature due to the dynamic coupling of decomposition steps to the lattice phonons of TiO2. We identify transient mobility of the oligomers as key to the self-assembly of the complete overlayer. The ease of preparation and thermal stability of this atomically precise system makes it highly suitable for a broad range of applications. Hierarchically ordered oxides are of critical importance in material science and catalysis. Unfortunately, the design and synthesis of such systems remains a key challenge to realizing their potential. In this study, we demonstrate how the deposition of small oligomeric (MoO3)1–6 clusters—formed by the facile sublimation of MoO3 powders—leads to the self-assembly of locally ordered arrays of immobilized mono-oxo (MoO3)1 species on anatase TiO2(101). Using both high-resolution imaging and theoretical calculations, we reveal the dynamic behavior of the oligomers as they spontaneously decompose at room temperature, with the TiO2 surface acting as a template for the growth of this hierarchically structured oxide. Transient mobility of the oligomers on both bare and (MoO3)1-covered TiO2(101) areas is identified as key to the formation of a complete (MoO3)1 overlayer with a saturation coverage of one (MoO3)1 per two undercoordinated surface Ti sites. Simulations reveal a dynamic coupling of the reaction steps to the TiO2 lattice fluctuations, the absence of which kinetically prevents decomposition. Further experimental and theoretical characterizations demonstrate that (MoO3)1 within this material are thermally stable up to 500 K and remain chemically identical with a single empty gap state produced within the TiO2 band structure. Finally, we see that the constituent (MoO3)1 of this material show no proclivity for step and defect sites, suggesting they can reliably be grown on the (101) facet of TiO2 nanoparticles without compromising their chemistry.
A statistical approach to domain performance modeling for oxyhalide primary lithium batteries

Lithium batteries have emerged as the power source of choice for a large number of commercial and medical applications. Commercially important lithium battery chemistries include lithium/iodine, lithium silver vanadium oxide, lithium/carbon monofluoride, lithium/sulfuryl chloride with chlorine, and lithium/thionyl chloride. The ability to accurately estimate the discharge performance of a cell is a paramount consideration in cell selection. Here, the authors present an approach to model the discharge of the oxyhalide system based on response surface methods and nonlinear estimation. The resulting models may be used to predict performance under varying conditions. In short, they construct a model to address the question: "how long will it last? ".
Reinertia, a New Subgenus of the Genus Aedes Meigen and Its Type Species Aedes (Reinertia) suffusus (Diptera: Culicidae), Newly Recorded From Bhutan

Abstract A new subgenus, Reinertia Somboon, Namgay & Harbach, of the genus Aedes Meigen and its type species, Ae. suffusus Edwards, are described from specimens reared from larvae and pupae found in a tree hole in Bhutan. The scutum of the adults is mostly covered with narrow pale falcate scales. The proboscis, maxillary palpus, tibiae, and tarsi are dark-scaled. The gonocoxite of the male genitalia bears a unique setose basomesal sclerite. The larva closely resembles larvae of the subgenus Downsiomyia Vargus in having setae 4–6-C with numerous branches and inserted more or less on level with seta 7-C, abdominal seta 12-I is present and the comb is composed of 6–10 spine-like scales arranged in an irregular row. Surprisingly, Reinertia shares features of the adult habitus, male genitalia, and larva with the Palearctic subgenus Dahliana Reinert, Harbach & Kitching. However, in phylogenetic analyses of the mitochondrial COI gene of species representing 38 subgenera of Aedes and six other genera of the tribe Aedini Neveu-Lemaire, Reinertia was not associated with Dahliana or Downsiomyia. In both maximum likelihood and Bayesian analyses of the data, Ae. suffusus was recovered as the weakly supported sister of a clade composed of five species of the subgenus Protomacleaya Theobald. In the absence of strong support, and because Protomacleaya is an unnatural group of species that resemble each other phenetically by virtue of what they lack, Ae. suffusus cannot be placed in the subgenus Protomacleaya. Thus, the morphological and molecular data attest the uniqueness of Ae. suffusus and its recognition as a monobasic subgeneric lineage.
Hsa_circ_0001073 targets miR‐626/LIFR axis to inhibit lung cancer progression

Circular RNAs (circRNAs) are associated with lung cancer progression. However, it is unclear whether and how circRNA hsa_circ_0001073 (circ_0001073) are involved in lung cancer progression. circ_0001073, microRNA (miR)‐626, and leukemia inhibitory factor receptor (LIFR) abundances were determined via quantitative reverse transcription polymerase chain reaction or western blot. Cell viability, invasion, and apoptosis were analyzed by cell counting kit‐8, transwell analysis and flow cytometry, respectively. The target correlation was tested by dual‐luciferase reporter analysis or RNA immunoprecipitation. Results showed that circ_0001073 abundance was down‐regulated in lung cancer cells. circ_0001073 constrained cell viability and invasion and facilitated apoptosis in lung cancer cells. miR‐626 was targeted via circ_0001073, and circ_0001073 inhibited lung cancer progression via reducing miR‐626 expression. LIFR was targeted via miR‐626, and miR‐626 knockdown constrained cell viability and invasion and facilitated apoptosis in lung cancer cells via up‐regulating LIFR. circ_0001073 increased LIFR expression via miR‐626 in lung cancer cells. In conclusion, circ_0001073 represses lung cancer progression via miR‐626/LIFR axis, indicating the potential value of circ_0001073 in lung cancer treatment.
Shotgun Metagenomic Analysis of Kombucha Mutualistic Community Exposed to Mars-like Environment outside the International Space Station.

Kombucha is a multispecies microbial ecosystem mainly composed by acetic acid bacteria and osmophilic acid-tolerant yeasts, which is used to produce a probiotic drink. Furthermore, Kombucha Mutualistic Community (KMC) has been recently proposed to be used during long space missions as both a living functional fermented product to improve astronauts' health and an efficient source of bacterial nanocellulose. In this study, we compared KMC structure and functions before and after samples were exposed to the space/Mars-like environment outside the International Space Station in order to investigate the changes related to their readaptation to Earth-like conditions by shotgun metagenomics, using both diversity and functional analyses of Community Ecology and Complex Networks approach. Our study revealed that the long-term exposure to space/Mars-like conditions on low Earth orbit may disorganize the KMC to such extent that it will not restore the initial community structure; however, KMC core microorganisms of the community were maintained. Nonetheless, there were no significant differences in the community functions, meaning that the KMC communities are ecologically resilient. Therefore, despite the extremely harsh conditions, key KMC species revived and provided the community with the genetic background needed to survive long periods of time under extraterrestrial conditions. This article is protected by copyright. All rights reserved.
Prospective association between dietary patterns and BMI Z-score in Brazilian adolescents

Abstract Objective: To identify dietary patterns and prospectively evaluate their influence on the BMI Z-score of adolescents. Design: A longitudinal study, using data from the Longitudinal Study on Sedentary Behavior, Physical Activity, Eating Habits and Adolescent Health – LONCAAFS. Setting: To obtain data on food consumption, a 24-h recall survey was conducted; a second 24-h recall was applied to 30 % of the sample in all waves. Dietary patterns were identified by exploratory factor analysis using principal components. BMI Z-score was determined according to the recommendation of the WHO, based on the BMI for age and sex. Socio-economic data, sedentary behaviour and physical activity level were obtained. Associations between BMI Z-score and dietary patterns and between BMI Z-score and variables of interest were determined using generalised estimating equations. Participants: Totally, 1431 adolescents were assessed in 2014, 1178 in 2015, 959 in 2016 and 773 in 2017, belonging to the public schools of João Pessoa, Northeast Brazil. Results: Three dietary patterns were identified throughout the study: ‘traditional’, ‘snacks’ and ‘Western’. The ‘Western’ dietary pattern was positively associated with BMI Z-score (β = 0·025; 95 % CI 0·002, 0·048), regardless of sex and physical activity level, prospectively. Conclusion: A dietary pattern composed of foods with high energy density, high fat and sugars, and low fibre influences the BMI Z-score of adolescents over time.
Establishment and histopathological study of patient-derived xenograft models and primary cell lines of epithelioid malignant peritoneal mesothelioma

Malignant peritoneal mesothelioma (MPM) is a rare malignancy with few experimental models. This study used the human surgical specimen to establish MPM patient-derived xenograft (PDX) models and primary cell lines to provide a study platform for MPM in vitro and in vivo, and conducted histopathological analysis. Our study used the experimental peritoneal cancer index (ePCI) score to evaluate gross pathology, and the results showed that the ePCI score of the female and male nude mice were 8.80 ± 1.75 and 9.20 ± 1.81 (P=0.6219), respectively. The Hematoxylin and eosin (HE) staining of animal models showed that the tumor was epithelioid mesothelioma and invaded multiple organs. Immunohistochemistry (IHC) staining showed that Calretinin, Cytokeratin 5/6, WT-1 and Ki-67 were all positive. The Swiss-Giemsa and Immunofluorescence (IF) staining of primary cell lines were also consistent with the pathological characteristics of mesothelioma. We also performed the whole-exome sequencing (WES) to identify the mutant genes between models and the patient. And the results showed that 21 mutant genes were shared between the two groups, and the genes related to tumorigenesis and development including BAP1, NF2, MTBP, NECTIN2, CDC23, LRPPRC, TRIM25, and DHRS2. In conclusion, the PDX models and primary cell lines of MPM were successfully established with the epithelioid mesothelioma identity confirmed by histopathological evidence. Moreover, our study has also illustrated the shared genomic profile between models and the patient.
In situ and operando electron microscopy in heterogeneous catalysis—insights into multi-scale chemical dynamics

This review features state-of-the-art in situ and operando electron microscopy (EM) studies of heterogeneous catalysts in gas and liquid environments during reaction. Heterogeneous catalysts are important materials for the efficient production of chemicals/fuels on an industrial scale and for energy conversion applications. They also play a central role in various emerging technologies that are needed to ensure a sustainable future for our society. Currently, the rational design of catalysts has largely been hampered by our lack of insight into the working structures that exist during reaction and their associated properties. However, elucidating the working state of catalysts is not trivial, because catalysts are metastable functional materials that adapt dynamically to a specific reaction condition. The structural or morphological alterations induced by chemical reactions can also vary locally. A complete description of their morphologies requires that the microscopic studies undertaken span several length scales. EMs, especially transmission electron microscopes, are powerful tools for studying the structure of catalysts at the nanoscale because of their high spatial resolution, relatively high temporal resolution, and complementary capabilities for chemical analysis. Furthermore, recent advances have enabled the direct observation of catalysts under realistic environmental conditions using specialized reaction cells. Here, we will critically discuss the importance of spatially-resolved operando measurements and the available experimental setups that enable (1) correlated studies where EM observations are complemented by separate measurements of reaction kinetics or spectroscopic analysis of chemical species during reaction or (2) real-time studies where the dynamics of catalysts are followed with EM and the catalytic performance is extracted directly from the reaction cell that is within the EM column or chamber. Examples of current research in this field will be presented. Challenges in the experimental application of these techniques and our perspectives on the field’s future directions will also be discussed.
A histological study of the song system of the carrion crow (Corvus corone)

The song system of songbirds (oscines) is one of the best studied neuroethological model systems. So far, it has been treated as a relatively constrained sensorimotor system. Songbirds such as crows, however, are also known for their capability to cognitively control their audio‐vocal system. Yet, the neuroanatomy of the corvid song system has never been explored systematically. We aim to close this scientific gap by presenting a stereotactic investigation of the extended song system of the carrion crow (Corvus corone), an oscine songbird of the corvid family that has become an interesting model system for cognitive neuroscience. In order to identify and delineate the song nuclei, the ascending auditory nuclei, and the descending vocal‐motor nuclei, four stains were applied. In addition to the classical Nissl‐, myelin‐, and a combination of Nissl‐and‐myelin staining, staining for tyrosine hydroxylase was used to reveal the distribution of catecholaminergic neurons (dopaminergic, noradrenergic, and adrenergic) in the song system. We show that the crow brain contains the important song‐related nuclei, including auditory input and motor output structures, and map them throughout the brain. Fiber‐stained sections reveal putative connection patterns between the crow's song nuclei comparable to other songbirds.