Miracle-dz/UniFAR-FTUs huggingface dataset:
Relationships among clinical judgment, self-report, and breath-analysis measures of intoxication in alcoholics.

Three studies comparing alcoholics' self-reports, observers' ratings, and breath-test determinations of alcohol intoxication found that (a) alcoholics' self-reports of their recent drinking were valid when they had not been drinking; (b) when they had been drinking, their self-reports were frequently invalid and underreported; (c) incidence of discrepant self-reports was not a function of level of intoxication; and (d) trained observers could identify only 50% to 67% of the subjects who were intoxicated but gave invalid self-reports. Breath analysis for blood alcohol concentration should be a mandatory component of alcohol treatment programs and alcohol treatment outcome evaluations.
Chronic rejection of rat renal allograft

Chronic allograft rejection is both a clinical and a histopathological diagnosis. Until recently, the histological definition of chronic renal allograft rejection was based on clinical diagnostic biopsies, where the evidence was partially obscured by recurrence of the original renal disease, and/or by administration of immunosuppressive drugs. In this communication, we present an experimental rat model for chronic renal allograft rejection, devoid of recurrence of the original disease. By comparing allografts to similarly immunosuppressed syngeneic transplants, we define which histological features should be attributed to chronic rejection and which to cyclosporin nephrotoxicity. Rat renal transplants were performed from DA (Ag-B4, RT1av1) to WF strain (Ag-B2, RT1u) or, for control, to DA strain, and immunosuppressed for 2 or 3 weeks with cyclosporin using a variety of different dosages. The animals were monitored weekly for serum creatinine levels and for blood cyclosporin concentrations, and core needle biopsies were performed on the grafts at regular intervals. At 3 months post-transplantation the animals were sacrificed and a complete histopathological evaluation was performed. Thirty-one histological variables were scored blindly by two investigators and separately for the graft interstitium, glomeruli, tubuli, and the graft vasculature. The following histological alterations were significantly more prominent in allografts than in similarly immunosuppressed syngeneic transplants: the intensity of interstitial inflammation, particularly the degree of pyroninophilia within the inflammatory cell population; the extent of glomerular mesangial matrix increase, basement membrane thickening, and glomerular sclerosis; the increase in the vascular intimal thickness affecting in particular the first and second order branches of the renal artery; and the obliteration of the graft vasculature. These alterations were considered as being primarily due to chronic rejection. In contrast, the extent of interstitial fibrosis and the extent of tubular changes, including tubular epithelial vacuolation, epithelial atrophy, and tubular basement membrane changes, were not significantly different in the allografts as compared to the syngeneic controls. These alterations were attributed primarily to cyclosporin nephrotoxicity. Serial monitoring of the grafts by needle biopsies clarified the sequence of events in the development of the chronic alterations in the transplant. The first event, as expected, was tubulointerstitial pyroninophilic inflammation, resembling that of acute episodes of rejection. This was significantly stronger and appeared earlier in allografts immunosuppressed for 2 rather than for 3 weeks. Vascular alterations developed next. The last to develop were the glomerular lesions.
PREPARATION OF A MONOCLONAL ANTIBODY AGAINST MOUSE BRAIN NATRIURETIC PEPTIDE (BNP) AND TISSUE DISTRIBUTION OF BNP IN MICE

1. In order to explore the significance of brain natriuretic peptide (BNP), a cardiac hormone secreted from the ventricle, in mice, we prepared a monoclonal antibody against mouse BNP (mBNP) and established a specific radioimmunoassay (RIA) for mBNP.
7.5 kV 4H-SiC GTO's for power conversion

There is a growing demand for medium voltage, 6.5-24 kV, switches capable of operating at more than 15 kHz frequencies. The range of potential applications includes grid-tied solar inverters and pulsed-power applications, where the conventional silicon thyristor technology is plagued with slow switching speeds at medium blocking voltage requirements. In this paper we present the design and characterization of 7.5 kV 4H-SiC Gate-Turn-Off thyristors (GTO's) with multiple floating guard-ring edge termination, and present GTO switching performance at 10 kHz in an AC-link™ [1] inverter.
The Process of Textbook Approval: A Critical Analysis

Up to the recent past, Textbook Boards were the only institutions in Pakistan that had the mandate to develop textbooks for both government and private schools affiliated with public examination bodies of the country. These boards have been working under their respective provincial governments. This situation developed a culture of using a single-textbook 1 in schools across the country. However, availing the provision given in the recent National Educational Polices of Pakistan, various private publishers have also been developing textbooks for both private and government schools. As per policy, before launching any textbook in the government schools, it is presented to the Ministry of Education for review and approval. Under this policy decision, the Curriculum Wing, Ministry of Education, Government of Pakistan has approved various textbook series by private sector for classes 1 to 5 along with that of the Textbook Boards’ during 2001-2004. This study analyzes these approved textbooks and their approval procedure by using CIPP Model. Data were collected through (a) interviews of the officials of the Textbook Boards, textbook developers and the Ministry of Education (b) analysis of the approved textbooks and (c) document analysis. The study discovered that there is a need to improve the existing procedure of the ministry for acquiring textbook approval.
Circulating Lipoprotein Profiles are Modulated Differently by Lipoprotein Lipase in Obese Humans

Background Several genetic analyses have suggested that lipoprotein lipase (LpL) genotypes causing decreased LpL activity correlate with increased triglyceride concentrations and risk for coronary artery disease. In contrast, in some other studies LpL activity was positively correlated with plasma low-density lipoprotein (LDL) cholesterol concentrations. Objective To assess whether these different associations represent physiologic differences in lipoprotein metabolism. Methods We correlated postheparin lipase activities, postprandial lipemia, and fasting lipoprotein concentrations in obese (BMI ≥ 30 kg/m2, n = 26) and non-obese (BMI ≤ 30 kg/m2, n = 57) individuals. LpL was measured using specific inhibitory antibodies. Results Surprisingly, LpL activity was significantly correlated with triglyceride area under the curve after a fat load in the non-obese, but not the entire group. Moreover, in non-obese individuals, LpL activity correlated directly (r= 0.40) and hepatic lipase activity correlated inversely (r = −0.32) with high-density lipoprotein (HDL) cholesterol concentrations. These relationships were not found in the obese group, in whom LpL correlated with LDL cholesterol concentrations (r = 0.54). Conclusions We conclude that postheparin LpL activity relates to different lipoproteins in obese and non-obese individuals. In obesity, greater LpL activity may enhance conversion of very-low-density lipoprotein cholesterol to LDL cholesterol, whereas in non-obese individuals the correlation is with HDL cholesterol. Whether this is due to differences in the source of LpL (muscle or fat), or to other associated alterations in lipoprotein metabolism is unknown. These results may explain the non-uniformity of correlations between LpL and atherogenic lipoproteins in different populations.
Tuned Spiral Resonators for Composite Metamaterials

Metamaterials composed of thin wires and spiral resonators have been studied in this paper. Technique to tune spiral resonators have been proposed. Transmission and reflection properties of metamaterials composed of thin wires and tuned spiral resonators have been simulated and compared with conventional metamaterials. The center frequency and transmission bandwidth of metamaterials have been varied through tuning of spiral resonators
Simple and inexpensive way for the treatment of guidewire-induced distal coronary perforation: subcutaneous fat tissue embolization

cardial infarction was admitted to the catheterization laboratory for primary percutaneous coronary intervention. Left anterior descending artery (LADa) was seen subtotally occluded immediately after the first diagonal artery (D1a) branching with TIMI 1 distal flow on coronary angiogram (Fig. 1a–c, Video 1–3). LADa and D1a were passed by a soft guidewire. After predilatation of the culprit lesion, guidewire-induced coronary perforation was noticed at the distal segment of D1a (Fig. 1d, Video 4). After 20 min inflation of balloon (Fig. 1e, f) at the perforation segment and culprit lesion treated by stent implantation, extravasation was found to be diminished (Fig. 1g, h, Video 5, 6). Echocardiography revealed minimal pericardial effusion without tamponade sign. On the development of clinical and echocardiographic tamponade signs at the first hour, fluorosAnatol J Cardiol 2016; 16: E-21-24 E-page Original Images E-23
Plasma Coenzyme Q 10 Levels and Prostate Cancer Risk : The Multiethnic Cohort Study

Background: Coenzyme Q10 (CoQ10) is considered to be a potential anticancer agent, but epidemiologic evidence regarding CoQ10 and prostate cancer risk is lacking. We examined the association of circulating CoQ10 levels with prostate cancer risk, using prediagnostic blood samples. Methods: Each of the 307 cases was individually matched to approximately 2 controls, for a total of 596 controls, on age, ethnicity, geographic location, date/time of specimen collection, and hours of fasting. Logistic regression was used to compute ORs and 95% CIs. Results: Therewasnooverall statistically significant associationof plasmaCoQ10 levelswithprostate cancer risk (Ptrend 1⁄4 0.50). However, after matched sets in which controls who had possible undiagnosed prostate cancer (prostate specific antigen value >4.0) were excluded, the ORs for quintiles 2 to 5 were all less than 1.0. Conclusions: The results suggest the possibility that moderate levels of circulating CoQ10 may be optimal for the reduction of prostate cancer risk; however, the findings were weak and not statistically significant. Because this is the first epidemiologic study of the association between CoQ10 and prostate cancer, further research on this topic is needed. Impact: If a nutritional factor such as CoQ10 were determined to reduce prostate cancer risk, it would have considerable public health significance because of the very high incidence of this cancer. Cancer Epidemiol Biomarkers Prev; 20(4); 708–10. 2011 AACR.
Based Tactile and Haptic Interaction Guidelines

In this paper, we survey guidance on tactile and haptic interactions provided by various researchers who were not in attendance at GOTHI-05. Its main purpose is to identify potential guidelines that might be incorporated into an international standard on tactile and haptic interaction. This survey also identified a number of controversial areas that will need to be dealt with in developing such a standard. Results are presented in a manner consistent with a companion paper "Initiating Guidance on Tactile and Haptic Interactions", by Fourney and Carter [8].
Long-term safety of divalproex sodium extended-release in children and adolescents with bipolar I disorder.

OBJECTIVE The objective of this open-label study was to assess the safety of divalproex sodium extended-release in the treatment of children and adolescents with acute mania associated with bipolar I disorder. METHODS This was a 6-month, Phase 3, open-label study in healthy subjects aged 9-17 years with a current Diagnostic and Statistical Manual of Mental Disorders, 4(th) edition, Text Revision (DSM-IV-TR) diagnosis of bipolar I disorder manic or mixed episode. Divalproex sodium extended-release (DVPX-ER) was initiated at 15 mg/kg per day on day 1 (not to exceed 750 mg/day) with increases allowed to a maximum of 35 mg/kg per day. Study visits were conducted on day 1 and at months 1, 2, 3, and 6. Assessments included standard safety evaluations and appropriate rating scales for clinical effect. RESULTS A total of 226 subjects were enrolled; 109 subjects completed the study. The most common adverse events were weight gain (16%), nausea (9%), and increased appetite (8%). Nonsymptomatic elevations of mean ammonia levels in plasma were observed. The mean Young Mania Rating Scale (YMRS) decreased 12.4 from baseline to final visit; small improvements were seen in behavior and caregiver stress ratings. CONCLUSIONS DVPX-ER was generally well tolerated in children and adolescents with acute mania, with a side-effect profile similar to that observed in adults.
[Ultrasonographic evaluation of the thyroid, determination of ioduria and iodine concentration in kitchen salt used by schoolchildren in Ribeirão Preto, São Paulo, Brazil].

OBJECTIVE AND METHODS Previous studies have pointed out that Ribeirão Preto, São Paulo, is an area of borderline iodine deficiency, later becoming a region of excessive iodination. In a reevaluation of the iodine status of the city in 2007-2008, 300 schoolchildren aged 8 to 10 years were evaluated, from 3 schools of 3 different socioeconomic levels who were submitted to the determination of iodine concentration in urine samples and in kitchen salt and thyroid ultrasound. RESULTS AND CONCLUSION Among boys and girls ioduria was higher in the school of highest socioeconomic level compared to the others, with a significant difference in the ages 8 and 10 years for boys with ranges : p < 0,0001 and p = 0,0106, respectively; and in the ages 8 and 9 years for girls with ranges: p = 0,0024 and p = 0,0154, respectively. Median iodine concentrations in samples of kitchen salt ranged from 26.6 to 27.8 mg iodine/kg and did not differ between the schools studied. Ultrasound evaluation revealed that 15,6% of thyroids examined were hypoechoic, suggesting that these glands may present changes in the architecture not reflected yet in their volume.
IN-SITU SUB-MICROMETER SURFACE FLOW VELOCITY MEASUREMENT

We have measured the flow velocity at a sub-micrometer distance from a flow channel wall by tracing the refractive index boundary of two consecutively flowed liquids. Using the surface plasmon resonance method to measure the surface proximity refractive index, we were able to measure the velocity without using additional tracer materials. This velocimetry can be performed while simultaneously measuring the reaction rate of surface immobilized biologically functioning molecules. Combining these two measurements enabled us to improve the fidelity of adsorption measurements of real samples undertaken using a capillary pumping biosensor by determining the flow velocity for each sample injection.
Finding an Optimal Bridge Between Two Polygons

Let π(a, b) denote the shortest path between two points a, b inside a simple polygon P, which totally lies in P. The geodesic distance between a and bin P is defined as the length of π (a, b), denoted by gd(a, b), in contrast with the Euclidean distance between a and b, denoted by d(a, b). Given two disjoint polygons Pand Q in the plane, the bridge problem asks for a line segment (optimal bridge)that connects a point p on the boundary of P and a point q on the boundary of Q such that the sum of three distances gd(p′, p), d(p, q)and gd(q, q′), with any p′ ∈ P and any q′ ∈ Q, is minimized. We present an O(nlog3n) time algorithm for finding an optimal bridge between two simple polygons. This significantly improves upon the previous O(n2)time bound.
How to analyze publication time trends by correspondence factor analysis: Analysis of publications by 48 countries in 18 disciplines over 12 years

This study is a follow‐up to a published Correspondence Factorial Analysis (CFA) of a dataset of over 6 million bibliometric entries (Dore et al. JASIS, 47(8), 588– 602,1996), which compared the publication output patterns of 48 countries in 18 disciplines over a 12‐year period (1981–1992). It analyzes by methods suitable for investigating short time series how these output patterns evolved over the 12‐year span. Three types of approach are described: (1) the chi2 distances of the publication output patterns from the center of gravity of the multidimensional system—which represents an average world pattern—were calculated for each country and for each year. We noted whether the patterns moved toward or away from the center with time; (2) individual annual output patterns were introduced as supplementary variables into an existing global overview covering the whole time‐span [CFA map of (countries × disciplines)]. We observed how these patterns moved about within the map year by year; (3) the matrix (disciplines × time) was analyzed by CFA to derive time trends for each country. CFA revealed the “inner clocks” governing publication trends. The time scale that best fitted the data was not a linear but an elastic scale. Although different countries laid emphasis on publication in different disciplines, the overall tendency was toward greater uniformity in publication patterns with time.
Recognition of Sulfamethoxazole and Its Reactive Metabolites by Drug-Specific CD4+ T Cells from Allergic Individuals1

The recognition of the antibiotic sulfamethoxazole (SMX) by T cells is usually explained with the hapten-carrier model. However, recent investigations have revealed a MHC-restricted but processing- and metabolism-independent pathway of drug presentation. This suggested a labile, low-affinity binding of SMX to MHC-peptide complexes on APC. To study the role of covalent vs noncovalent drug presentation in SMX allergy, we analyzed the proliferative response of PBMC and T cell clones from patients with SMX allergy to SMX and its reactive oxidative metabolites SMX-hydroxylamine and nitroso-SMX. Although the great majority of T cell clones were specific for noncovalently bound SMX, PBMC and a small fraction of clones responded to nitroso-SMX-modified cells or were cross-reactive. Rapid down-regulation of TCR expression in T cell clones upon stimulation indicated a processing-independent activation irrespective of specificity for covalently or noncovalently presented Ag. In conclusion, our data show that recognition of SMX presented in covalent and noncovalent bound form is possible by the same TCR but that the former is the exception rather than the rule. The scarcity of cross-reactivity between covalently and noncovalently bound SMX suggests that the primary stimulation may be directed to the noncovalently bound SMX.
Business modeling.

This thesis covers the following aspects: 1. The E/R notation and the REA model notation in UML for accounting and a retail shop enterprise, 2. Analysis of enterprises in general and enterprise solution, 3. Construction of enterprise solutions using Microsoft architecture and Navision Jamaica, 4. In the end some suggestions are presented for improving modeling enterprises and enterprise solutions. Rationale Present-day business life requires software applications to perform management solutions for enterprises. These software applications are named ent rprise solutions. Enterprise solution improves an enterprise’s infrastructure and helps to run a business. Rapid development of information technologies creates a shift from software engineering to modeling engineering. Now the process of analysis and modeling of the enterprise domain plays a key role in construction of enterprise solutions. This thesis examines some recent techniques for business modeling and strategies for constructing enterprise solutions. The goal of this project is to indicate possibilities for enterprise modeling. Subjects of conceptual modeling and ontologies are emphasized as having big potential for enterprise modeling and future enterprise solutions. Report structure The report is structured as follows: • Chapter 1 provides an introduction to the report along with brief description of the content; • Chapter 2 examines the E/R notation and REA notation for enterprise modeling. A REA model of a retail shop enterprise is taken as a study example. Possibilities to represent REA model in UML notation are suggested; • Chapter 3 explains artifacts of business enterprise and enterprise solution. General aspects of enterprise functioning are described in order to establish a base for modeling an enterprise solution. The chapter defines the role of enterprise solution in enterprise functioning. The chapter shortly covers requirements for
On the impact of the solution representation for the Internet Protocol Network Design Problem with max‐hop constraints

The IP (Internet Protocol) Network Design Problem can be shortly stated as follows. Given a set of nodes and a set of traffic demands, we want to determine the minimum cost capacity installation such that all the traffic is routed. Capacity is provided by means of links of a given capacity and traffic must be loaded on the network according to the OSPF‐ECM (Open Shortest Path First—Equal Commodity Multiflow) protocol, with additional constraints on the maximum number of hops. The problem is strongly NP‐Hard, and the literature proposes local search‐based heuristics that do not take into account max‐hop constraints, or assume a simplified OSPF routing. The core in a local search approach is the network loading algorithm for the evaluation of the neighbor solutions costs. It presents critical aspects concerning both computational efficiency and memory requirements. Starting from a tabu search prototype, we show how these aspects deeply impact on the design of a local search procedure, even at the logical level. We present several properties of the related network loading problem, that allow to overcome the critical issues and lead to an efficient solution evaluation. © 2004 Wiley Periodicals, Inc. NETWORKS, VoL. 44(2), 73–83 2004
Differences in technique between sprinters and distance runners at equal and maximal speeds

In the finishing kick of a distance race, maximizing speed becomes the focus even if economy may be sacrificed. If distance runners knew how to alter their technique to become more sprint-like, this process could be more successful. In this study, we compared the differences in technique between sprinters and distance runners while running at equal and maximal speeds. Athletes consisted of 10 Division I distance runners, 10 Division I sprinters, and 10 healthy non-runners. They performed two tests, each consisting of a 60-m run on the track: Test 1 at a set pace of 5.81 m/s, while Test 2 was maximal speed. Video was collected at 180 Hz. Significant differences (P < 0.05) between the sprint and distance groups at maximal speeds were found in the following areas: speed, minimum hip angle, knee extension at toe-off, stride length, contact time, and recovery knee at touchdown. In Test 1, sprinters and distance runners displayed many of the same significant differences. The control group was similar to the distance group in both trials. As distance runners attempt to sprint, the desired adjustments do not necessarily occur. Distance runners may benefit from biomechanical interventions to improve running speed near the end of a race.
Are we experiencing a big data bubble?

Fatma Ozcan IBM Almaden Research Center San Jose, CA fozcan@us.ibm. com Nesime Tatbul Intel Labs and MIT Cambridge, MA tatbul@csail.mit. edu Daniel J. Abadi Yale University New Haven, CT dna@cs.yale. edu Marcel Kornacker Cloudera San Francisco, CA marcel@cloudera.com C Mohan IBM Almaden Research Center San Jose, CA cmohan@us.ibm. com Karthik Ramasamy Twitter, Inc. San Francisco, CA karthik@twitter.com Janet Wiener Facebook, Inc. Menlo Park, CA jlw@fb.com