Miracle-dz/UniFAR-FTUs huggingface dataset:
Labeled Triangle Indexing for Efficiency Gains in Distributed Interactive Subgraph Search††This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344 (LLNL-CONF-814976). Experiments were performed at the Live

Subgraph search in a massive background graph, i.e., pattern matching in graphs, is a challenging problem, particularly in an interactive usage scenario where fast response time is important. Our approach, Prune.Juice [1], is based on two intuitions: first, rather than directly searching for individual matches, it is cheaper to eliminate vertices and edges of the background graph that do not participate in any match. Second, to perform this pruning process, it is possible to decompose a search pattern into a set of constraints, and use each of these constraints to eliminate non-matching vertices and edges. This paper explores the feasibility of indexing the background graph to accelerate the checking of non-local constraints (e.g., cycles and paths), the most expensive phase of pruning. In particular, we demonstrate that indexing labeled triangle (i.e., a 3-Cycle) participation is a valuable acceleration technique. Additionally, we observe that labeled triangle counts at edges can be employed to detect 3-Paths that have terminal points with non-unique labels, at relatively little extra cost. Such paths and triangles are basic sub-constraints that can be used to rapidly prune non-matching vertices and edges. As proof of concept, we show that, using triangle information alone, indexing further accelerates expensive queries in Prune.Juice by up to $\mathbf{500}\times$ on billion-edge graphs.
Adherence to Antirheumatic Treatments in Patients with Chronic Inflammatory Rheumatic Disease

Objectives: To evaluate the prevalence of non-adherence to corticosteroid, disease-modifying antirheumatic drug (DMARD) and biologic treatments in patients managed for chronic inflammatory rheumatic disease (CIRD), to identify socioeconomic and demographic factors, and factors linked to the disease or treatment affecting adherence, to look for possible correlations between non-adherence and negative opinions about drugs, doctors or medicines and between non-adherence and negative perceptions of disease and health in general. Abstract Methods: A medical record review study performed between January 2014 and December 2017 on patients followed for CIRD and treated with biologics and/or with DMARDs and/or corticosteroids for at least three months. The patients completed a questionnaire concerning adherence to treatment comprising the Morisky-Green adherence questionnaire (MMAS-4) the medication possession ratio (MPR) for each immunomodulatory treatment underway, and questionnaires relating to the patient’s opinions about drugs (18-item BMQ), disease perception (BIPQ) and health in general (PHQ-2). Poor treatment adherence was defined as an MPR < 80% and/or a score of 2/4 for the MMAS-4. Patients with an MPR < 100% were included in secondary uni-and multivariate analyses. Conclusion: Two factors predictive of poor treatment adherence were identified: being male and multiple treatments. Therapeutic education is particularly recommended for this at-risk population. Results: Complete responses were obtained from 177 patients, 70% of whom reported general adherence to their treatment. The overall adherence rates were 69.6% for biologics, 66.3% for DMARDs and 63.6% for corticosteroids. In multivariate analysis, being male and having multiple antirheumatic treatments emerged as factors independently associated with poor treatment adherence.
Cross-modal, Cross-domain Biometric Systems

—We demonstrate three biometric systems, including cross-domain age estimation, cross-resolution face recognition, and cross-modal person re-identiﬁcation (ReID). Recently, various facial age estimation systems have been developed and deployed. However, their performance tends to degrade in unseen scenarios. We present a robust age estimation system, showing better performance in real-world scenarios. For cross-resolution face recognition, we use a distillation based approach to train deep neural networks. Our proposed approach outperforms many state-of-the-art solutions for low-resolution and cross-resolution face recognition tasks. For cross-modal ReID we learn a joint embedding space for vision and language to perform cross-modal search. Interestingly, the multimodal approach sig-niﬁcantly enhances the performance of the vision modality.
Scotty

Window aggregation is a core operation in data stream processing. Existing aggregation techniques focus on reducing latency, eliminating redundant computations, or minimizing memory usage. However, each technique operates under different assumptions with respect to workload characteristics, such as properties of aggregation functions (e.g., invertible, associative), window types (e.g., sliding, sessions), windowing measures (e.g., time- or count-based), and stream (dis)order. In this article, we present Scotty, an efficient and general open-source operator for sliding-window aggregation in stream processing systems, such as Apache Flink, Apache Beam, Apache Samza, Apache Kafka, Apache Spark, and Apache Storm. One can easily extend Scotty with user-defined aggregation functions and window types. Scotty implements the concept of general stream slicing and derives workload characteristics from aggregation queries to improve performance without sacrificing its general applicability. We provide an in-depth view on the algorithms of the general stream slicing approach. Our experiments show that Scotty outperforms alternative solutions.
Running head: 1 On The Causal Relation Between Real World Activities and Emotional Expressions of Social Media Users

Social interactions through online social media have become a daily routine of many, and the number of those whose real-world (offline) and online lives have become intertwined is continuously growing. As such, the interplay of individuals’ online and offline activities has been the subject of numerous research studies, the majority of which explored the impact of people’s online actions on their offline activities. The opposite direction of impact the effect of real-world activities on online actions has also received attention but to a lesser degree. To contribute to the latter form of impact, this paper reports on a quasi-experimental design study that examined the presence of causal relations between real-world activities of online social media users and their online emotional expressions. To this end, we have collected a large dataset (over 17K users) from Twitter and Foursquare, and systematically aligned user content on the two social media platforms. Users’ Foursquare check-ins provided information about their offline activities, whereas the users’ expressions of emotions and moods were derived from their Twitter posts. Since our study was based on a quasi-experimental design, to minimise the impact of covariates, we applied an innovative model of computing propensity scores. Our main findings can be summarised as follows: (i) users’ offline activities do impact their affective expressions, both of emotions and moods, as evidenced in their online shared textual content; (ii) the impact depends on the type of offline activity and if the user embarks on or abandons the activity. Our findings can be used to devise a personalised recommendation mechanism to help people better manage their online emotional expressions.
Children’s Participation in Decision Making From Child Welfare Workers’ Perspectives: A Systematic Review

This article explores child welfare workers’ experiences of children’s participation in decision making in the child protection system. The systematic review follows the principles of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement and includes 12 peer-reviewed articles published in academic journals from 2009 to 2019. Findings indicate that children’s participation in decision making is generally limited or nonexistent. The age of the child is an important determining factor concerning whether the child is given the opportunity to participate in decision making. Potential harm for children that may result from participation is considered when deciding on whether to include a child in the decision-making process.
Rewilding policy futures: Maori whakapapa and the ecology of the subject

The world is changing, but political and educational institutions appears to be stuck in the 19th century. Modern policy and education are both premised on an Enlightenment assumption of the human, rational, individual subject. Increasingly, elements of these philosophical premises are being interrogated. The critique emerges from the environmental interest in collapsing the dualism between subject and object, and reintegrating the human with/in our ecological context. Indigenous philosophy is important for rethinking the integration of the dualism between humanity and ecology. Maori philosophy is a vital counterpoint to the anthropomorphic position of modern policy and education. Taking Maori concepts to inform contemporary philosophy generates a substantive shift in world view that does not lose sight of the solipsist, phenomenological parameters of human sense making, but enables us to make deeper ethical decisions, and transform the basis of education and policy.
INVESTIGATING THE CONSUMERS' PERCEPTION TOWARDS USAGE OF PLASTIC MONEY IN BANGLADESH: AN APPLICATION OF CONFIRMATORY FACTOR ANALYSIS

Technology has drastically changed all the sectors including the financial sector, and the transactions in the banking system have also undergone a remarkable change. The traditional concept of payment through cash is replaced by the credit cards or the debit cards called ‘plastic money’ that people are using to draw money or to make purchases. This particular research focuses on the perception about the acceptance of plastic money, its usability and affordability while they are making an impact on its preference of use in Bangladesh. Data have been collected from 202 respondents using a semi-structured questionnaire covering students, government service holders, employees of private organizations, and businessman. It is found that most of the respondents are using plastic money usually for shopping and international purchases, and also for purchasing expensive products. In order to identify the latent variables regarding the perception of using plastic money, factor analysis has been incorporated. Factor analysis extracted three latent factors, namely, influential factor for using plastic money, beneficial factor of using plastic money, and problems in using plastic money. Confirmatory factor analysis has also been done in order to get the degree of effect of the observed variables on the extracted factors. And it is found that among the influential variables, people are mostly influenced for using plastic money because they think it adds value in their lifestyle. Secure transaction is the most beneficial reason of using plastic money according to the respondents. The problems of using plastic money as found through confirmatory factor analysis, are unavailability of money in ATM (Automated Teller Machine) booths, unavailability of technology of payment through plastic money in purchase points, and the technological complications faced by the card holders.
RNA-Seq Dataset From Isolated Leukocytes Following Spontaneous Intracerebral Hemorrhage in Zebrafish Larvae

Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance, University of Manchester, Manchester, United Kingdom, Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, School of Biological Sciences, University of Manchester, Manchester, United Kingdom, 3 Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, United Kingdom, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, School of Biological Sciences, University of Manchester, Manchester, United Kingdom
Draft Genomes and Comparative Analysis of Seven Mangrove Rhizosphere-Associated Fungi Isolated From Kandelia obovata and Acanthus ilicifolius

Mangroves are one of the most productive and biologically diverse ecosystems, with unique plants, animals, and microorganisms adapted to the harsh coastal environments. Although fungi are widely distributed in the mangrove ecosystem and they are playing an important role in the decomposition of organic matter, their genomic profiles are still poorly understood. In this study, we isolated seven Ascomycota fungi (Westerdykella dispersa F012, Trichoderma lixii F014, Aspergillus tubingensis F023, Penicillium brefeldianum F032, Neoroussoella solani F033, Talaromyces fuscoviridis F034, and Arthrinium marii F035) from rhizospheres of two mangroves of Kandelia obovata and Acanthus ilicifolius. We sequenced and assembled the whole genome of these fungi, resulting in size ranging from 29 to 48 Mb, while contig N50 from 112 to 833 Kb. We generated six novel fungi genomes except A. tubingensis, and the gene completeness and genome completeness of all seven genomes are higher than 94%. Comparing with non-mangrove fungi, we found Carbohydrate-Binding Modules (CBM32), a subfamily of carbohydrate active enzymes, only detected in two mangrove fungi. Another two subfamilies, Glycoside Hydrolases (GH6) and Polysaccharide Lyases (PL4), were significantly different in gene copy number between K. obovata and A. ilicifolius rhizospheres (P-value 0.041 for GH6, 0.047 for PL4). These findings may indicate an important influence of mangrove environments or hosts on the ability of decomposition in rhizosphere fungi. Secondary metabolite biosynthesis gene clusters were detected and we found the mangrove fungi averagely contain 18 Type I Polyketide (t1pks) synthase, which was significantly higher than 13 in non-mangrove fungi (P-value 0.048), suggesting their potential roles in producing bioactive compounds that important for fungi development and ecology. We reported seven mangrove-associated fungal genomes in this study and compared their carbohydrate active enzymes and secondary metabolites (SM) genes with those of non-mangrove fungi, and the results suggest that there are differences in genetic information among fungi in different habitats.
The Sonic Hedgehog–Patched–Gli Signaling Pathway Maintains Dental Epithelial and Pulp Stem/Progenitor Cells and Regulates the Function of Odontoblasts

This study aimed to elucidate the role of the Sonic hedgehog (Shh)–Patched (Ptch)–Gli signaling pathway in maintaining dental epithelial and pulp stem/progenitor cells and regulating the function of odontoblasts. Doxycycline (dox)-inducible histone 2B (H2B)–green fluorescent protein (GFP) transgenic mice ingested dox at prenatal embryonic days 14.5 or 15.5 and their offspring were collected from postnatal day 1 (P1) to week 3 (P3W). Immunohistochemistry for Gli1, Ptch1, and Ptch2 and in situ hybridization for Shh and Ptch1 were conducted. Mandibular incisors of postnatal day 2 H2B-GFP transgenic and wild-type mice were cultivated in a nutrient medium with Shh antibody for 4 days and subsequently processed for immunohistochemistry for Sox2. In molars, dense H2B-GFP-label-retaining cells (H2B-GFP-LRCs) were densely distributed throughout the dental pulp during P1 to postnatal week 2 (P2W) and decreased in number by postnatal P3W, whereas the number of dense H2B-GFP-LRCs in the subodontoblastic layer increased in number at P2W. Gli1+ and Pthc1+ cells were distributed throughout the enamel organ and dental pulp, including the odontoblast and subodontoblastic layers. Shh mRNA was expressed in the inner enamel epithelium and shifted into odontoblasts after dentin deposition. Ptch1 mRNA was expressed in the inner enamel epithelium and cuspal pulpal tissue on P1 and decreased in intensity from postnatal week 1 to P3W. In incisors, the apical bud contained H2B-GFP-LRCs, Gli1+ cells, and Ptch1+ cells. The addition of Shh antibody to explants induced a decrease in the number of Sox2+ cells due to the increase in apoptotic cells in the apical bud. Thus, the Shh–Ptch–Gli signaling pathway plays a role in maintaining quiescent adult stem cells and regulating the function of odontoblasts.
Examining the Research Criteria for Traumatic Encephalopathy Syndrome in Middle-Aged Men From the General Population Who Played Contact Sports in High School

Objective: There are no validated or agreed upon diagnostic clinical criteria for chronic traumatic encephalopathy or traumatic encephalopathy syndrome. This study examines the leading research criteria for traumatic encephalopathy syndrome (TES) in middle-aged men in the general population. Method: Participants were 409 men between the ages of 35 and 55 recruited through an online crowdsourcing platform. Participants provided demographic information, medication history, concussion history, contact sport history, current medication use, and current symptoms. Research criteria for TES were applied to the sample. Results: Over half of the total sample met TES symptom criteria (56.2%), without applying the neurotrauma exposure criteria. Those with 4+ prior concussions had higher rates of meeting TES criteria compared to those with 0–3 prior concussions, but the results were not statistically significant (69.8 vs. 54.6%; χ2 = 3.58, p = 0.06). Exposure to contact sports was not related to higher rates of TES (ps ≥ 0.55). In a binary logistic regression predicting the presence of mild or greater TES, significant predictors were sleep difficulties [Odds ratio (OR) = 6.68], chronic pain (OR = 3.29), and age (OR = 1.04). Neurotrauma exposure was not a significant predictor (p = 0.66). When analyzing those with no prior concussions or contact sport histories (n = 126), 45.2% met symptom criteria for mild or greater TES; chronic pain and sleep difficulties were associated with a higher prevalence of meeting criteria for TES in this subgroup (ps < 0.001). Conclusions: Men who participated in contact sports in high school or college were not more likely to meet criteria for TES than men who participated in non-contact sports or no sports. In a multivariable model, sleep problems and chronic pain were predictive of meeting the symptom criteria for TES, but the repetitive neurotrauma exposure criterion was not a significant predictor of meeting the TES symptom criteria.
A Multisensory fMRI Investigation of Nociceptive-Preferential Cortical Regions and Responses

The existence of nociceptive-specific brain regions has been a controversial issue for decades. Multisensory fMRI studies, which examine fMRI activities in response to various types of sensory stimulation, could help identify nociceptive-specific brain regions, but previous studies are limited by sample size and they did not differentiate nociceptive-specific regions and nociceptive-preferential regions, which have significantly larger responses to nociceptive input. In this study, we conducted a multisensory fMRI experiment on 80 healthy participants, with the aim to determine whether there are certain brain regions that specifically or preferentially respond to nociceptive stimulation. By comparing the evoked fMRI responses across four sensory modalities, we found a series of brain regions specifically or preferentially involved in nociceptive sensory input. Particularly, we found different parts of some cortical regions, such as insula and cingulate gyrus, play different functional roles in the processing of nociceptive stimulation. Hence, this multisensory study improves our understanding of the functional integrations and segregations of the nociceptive-related regions.
Accessibility Considerations in the National Children's Study

In the National Children's Study (NCS), assessments were proposed and developed that used a wide range of modes of administration (e.g., direct in-person interviews, telephone interviews, computer assisted interviews, self-administered questionnaires, real time and recall observations, and physical examinations). These modes of administration may pose accessibility challenges for some people with disabilities. Accessibility of measurement is important to consider because systematic exclusion of people with disabilities from research can lead to measurement bias and systematic error in derived scores. We describe our approach to analyzing the accessibility of measures in the NCS and describe the work of the Accessibility Domain Team. Finally, we describe a decision process for creating and using accessible health research measures.
The Genetic Pathways Underlying Immunotherapy in Dilated Cardiomyopathy

Heart failure (HF) is a global public health threat affecting 26 million individuals worldwide with an estimated prevalence increase of 46% by 2030. One of the main causes of HF and sudden death in children and adult is Dilated Cardiomyopathy (DCM). DCM is characterized by dilation and systolic dysfunction of one or both ventricles. It has an underlying genetic basis or can develop subsequent to various etiologies that cause myocardium inflammation (secondary causes). The morbidity and mortality rates of DCM remains high despite recent advancement to manage the disease. New insights have been dedicated to better understand the pathogenesis of DCM in respect to genetic and inflammatory basis by linking the two entities together. This cognizance in the field of cardiology might have an innovative approach to manage DCM through targeted treatment directed to the causative etiology. The following review summarizes the genetical and inflammatory causes underlying DCM and the pathways of the novel precision-medicine-based immunomodulatory strategies to salvage and prevent the associated heart failure linked to the disease.
The Succession of the Gut Microbiota in Insects: A Dynamic Alteration of the Gut Microbiota During the Whole Life Cycle of Honey Bees (Apis cerana)

The Asian honey bee Apis cerana is a valuable biological resource insect that plays an important role in the ecological environment and agricultural economy. The composition of the gut microbiota has a great influence on the health and development of the host. However, studies on the insect gut microbiota are rarely reported, especially studies on the dynamic succession of the insect gut microbiota. Therefore, this study used high-throughput sequencing technology to sequence the gut microbiota of A. cerana at different developmental stages (0 days post emergence (0 dpe), 1 dpe, 3 dpe, 7 dpe, 12 dpe, 19 dpe, 25 dpe, 30 dpe, and 35 dpe). The results of this study indicated that the diversity of the gut microbiota varied significantly at different developmental stages (ACE, P = 0.045; Chao1, P = 0.031; Shannon, P = 0.0019; Simpson, P = 0.041). In addition, at the phylum and genus taxonomic levels, the dominant constituents in the gut microbiota changed significantly at different developmental stages. Our results also suggest that environmental exposure in the early stages of development has the greatest impact on the gut microbiota. The results of this study reveal the general rule of gut microbiota succession in the A. cerana life cycle. This study not only deepens our understanding of the colonization pattern of the gut microbiota in workers but also provides more comprehensive information for exploring the colonization of the gut microbiota in insects and other animals.