Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparing the Linear and Quadratic Discriminant Analysis of Diabetes Disease Classification Based on Data Multicollinearity

Linear and quadratic discriminant analysis are two fundamental classification methods used in statistical learning. Moments (MM), maximum likelihood (ML), minimum volume ellipsoids (MVE), and t-distribution methods are used to estimate the parameter of independent variables on the multivariate normal distribution in order to classify binary dependent variables. The MM and ML methods are popular and effective methods that approximate the distribution parameter and use observed data. However, the MVE and t-distribution methods focus on the resampling algorithm, a reliable tool for high resistance. This paper starts by explaining the concepts of linear and quadratic discriminant analysis and then presents the four other methods used to create the decision boundary. Our simulation study generated the independent variables by setting the coefficient correlation via multivariate normal distribution or multicollinearity, often through basic logistic regression used to construct the binary dependent variable. For application to Pima Indian diabetic dataset, we expressed the classification of diabetes as the dependent variable and used a dataset of eight independent variables. This paper aimed to determine the highest average percentage of accuracy. Our results showed that the MM and ML methods successfully used large independent variables for linear discriminant analysis (LDA). However, the t-distribution method of quadratic discriminant analysis (QDA) performed better when using small independent variables.
Importation and circulation of rubella virus lineages 1E-L2 and 2B-L2c between 2018 and 2021 in China: Virus evolution and spatial–temporal transmission characteristics

Abstract To better understand the importation and circulation patterns of rubella virus lineages 1E-L2 and 2B-L2c circulating in China since 2018, 3,312 viral strains collected from 27 out of 31 provinces in China between 2018 and 2021 were sequenced and analyzed with the representative international strains of lineages 1E-L2 and 2B-L2c based on genotyping region. Time-scale phylogenetic analysis revealed that the global lineages 1E-L2 and 2B-L2c presented distinct evolutionary patterns. Lineage 1E-L2 circulated in relatively limited geographical areas (mainly Asia) and showed geographical and temporal clustering, while lineage 2B-L2c strains circulated widely throughout the world and exhibited a complicated topology with several independently evolved branches. Furthermore, both lineages showed extensive international transmission activities, and phylogeographic inference provided evidence that lineage 1E-L2 strains circulating in China possibly originated from Japan, while the source of lineage 2B-L2c isolated since 2018 is still unclear. After importation into China in 2018, the spread of lineage 1E-L2 presented a three-stage transmission pattern from southern to northern China, whereas lineage 2B-L2c spread from a single point in western China to all the other four regions. These two transmission patterns allowed both imported lineages to spread rapidly across China during the 2018–9 rubella epidemic and eventually established endemic circulations. This study provides critical scientific data for rubella control and elimination in China and worldwide.
Two-Stage Oxidative Leaching of Low-Grade Copper–Zinc Sulfide Concentrate

Bioleaching may be effectively used to extract nonferrous metals from sulfide ores and concentrates. At the same time, some minerals are refractory and their bioleaching rate is often comparatively low that does not allow the required metal extraction rate to be achieved. In the present work, we studied the two-stage process, which included stages of biological and chemical leaching, to improve copper extraction from low grade Cu–Zn sulfide concentrate containing chalcopyrite, tennantite, pyrite, and sphalerite. Bioleaching was conducted in the continuous mode in three laboratory scale reactors connected in series. The pulp density was 10% and the residence time was 7 days. The temperature was 40 °C in the 1st reactor and 50 °C in the 2nd and 3rd reactors. Bioleaching allowed the extraction of 29.5 and 78% of Cu and Zn, respectively. The solid bioleach residue obtained was then treated for additional Cu and Zn recovery using high temperature leaching at 90 °C for 25 h. The liquid phase of the bioleaching pulp contained Fe3+ ions, which is the strong oxidant, and the leach solution was supplemented with NaCl. In the presence of the maximal NaCl concentration (1 M), Cu and Zn extraction reached 48 and 84%. Thus, two-stage leaching may allow to increase bioleaching efficiency and may be used to improve the bioleaching rate of refractory minerals, such as chalcopyrite.
Respiration Detection of Ground Injured Human Target Using UWB Radar Mounted on a Hovering UAV

As an important and basic platform for remote life sensing, unmanned aerial vehicles (UAVs) may hide the vital signals of an injured human due to their own motion. In this work, a novel method to remove the platform motion and accurately extract human respiration is proposed. We utilized a hovering UAV as the platform of ultra-wideband (UWB) radar to capture human respiration. To remove interference from the moving UAV platform, we used the delay calculated by the correlation between each frame of UWB radar data in order to compensate for the range migration. Then, the echo signals from the human target were extracted as the observed multiple range channel signals. Owing to meeting the independent component analysis (ICA), we adopted ICA to estimate the signal of respiration. The results of respiration detection experiments conducted in two different outdoor scenarios show that our proposed method could accurately separate respiration of a ground human target without any additional sensor and prior knowledge; this physiological information will be essential for search and rescue (SAR) missions.
A Comprehensive Review of Cross-Linked Gels as Vehicles for Drug Delivery to Treat Central Nervous System Disorders

Gels are attractive candidates for drug delivery because they are easily producible while offering sustained and/or controlled drug release through various mechanisms by releasing the therapeutic agent at the site of action or absorption. Gels can be classified based on various characteristics including the nature of solvents used during preparation and the method of cross-linking. The development of novel gel systems for local or systemic drug delivery in a sustained, controlled, and targetable manner has been at the epitome of recent advances in drug delivery systems. Cross-linked gels can be modified by altering their polymer composition and content for pharmaceutical and biomedical applications. These modifications have resulted in the development of stimuli-responsive and functionalized dosage forms that offer many advantages for effective dosing of drugs for Central Nervous System (CNS) conditions. In this review, the literature concerning recent advances in cross-linked gels for drug delivery to the CNS are explored. Injectable and non-injectable formulations intended for the treatment of diseases of the CNS together with the impact of recent advances in cross-linked gels on studies involving CNS drug delivery are discussed.
Supersymmetry and the MSSM: An Elementary introduction

These notes are an expanded version of a short course of lectures given for graduate students in particle physics at Oxford. The level was intended to be appropriate for students in both experimental and theoretical particle physics.The purpose is to present an elementary and self-contained introduction to SUSY that follows on, relatively straightforwardly, from graduate-level courses in relativistic quantum mechanics and introductory quantum field theory. The notation adopted, at least initially, is one widely used in RQM courses, rather than the `spinor calculus' (dotted and undotted indices) notation found in most SUSY sources, though the latter is introduced in optional Asides. There is also a strong preference for a `do-it-yourself' constructive approach, rather than for a top-down formal deductive treatment. The main goal is to provide a practical understanding of how the softly broken MSSM is constructed. Relatively less space is devoted to phenomenology, though simple `classic' results are covered, including gauge unification, the bound on the mass of the lightest Higgs boson, and sparticle mixing. By the end of the course students (readers) should be provided with access to the contemporary phenomenological literature.
Cooperative Output Regulation of Singular Multiagent Systems Under Switching Topologies

In this article, we consider the cooperative output regulation of singular multiagent systems under jointly connected switching topologies. The original problem is transformed into a stabilization problem by model transformation with the proposed distributed controller. Different from most existing controllers, a new graph-based switching compensator and its corresponding communication protocol are synthesized into the controller. The communication network does not remain connected at any time. And a triggered mechanism is designed to ensure that the communication between each pair of agents does not need to take place continuously. In the triggered mechanism, a novel design pattern is adopted to avoid Zeno behavior. The method in this article can reduce the computation and communication, and obtain a better tracking effect at the same time compared to previous results. Finally, a numerical simulation is given to show the effectiveness of the controller and the triggered mechanism.
Implementation of a Standard Care Program of Therapeutic Exercise in Metastatic Breast Cancer Patients

Background: There is little information on the feasibility and benefit of therapeutic exercise (TE) in women with metastatic breast cancer (MBC). The aim of this article is to describe the implementation of a TE intervention in MBC patients, and to determine the recruitment, compliance and improvement in outcomes after its completion. Methods: The “Therapeutic Exercise program in MBC” (TEP-MBC) consists of 1 h of individualized TE supervised by a physiotherapist in a group format, consisting of four groups of seven to eight participants. TEP-MBC was delivered twice a week, lasting 12 weeks (22 sessions), with patients considered to have completed the program when attending at least 17 sessions (>75% attendance). After referral, patients underwent a clinical interview and a physical and functional assessment. This information was complemented with patient-reported outcomes. Data about referral, compliance and assessment were collected. Results: Only 11 of the 30 patients completed the program. Drop-out was mainly related to personal issues and symptoms arising from the disease or treatment. All patients who completed the program improved cancer-related fatigue and increased their functional parameters. Conclusions: The TEP-MBC was safe and feasible in patients with MBC, although with low compliance. The high variability in baseline measures reflects the heterogeneous level of function.
Effect of Systemic Lupus Erythematosus on some Biochemical Parameters in Female Patients

It has been noticed that there is an increase in the number of women suffering from SLE. Most studies confirmed that serum DHEA (dehydroepiandrosterone) and DHEA sulphate are lower among patients with SLE than among controls even- during phases of inactive disease so we performed this study to detect the level of DHEA-S in the female patients with SLE. The overall results confirm that DHEA treatment was well- tolerated, significantly reduced the number of SLE flares, and improved patient’s global assessment of disease activity. Some serum parameters like liver and kidney functions were detected. Biochemical analysis showed that there is a significant increase of total lipids, cholestrol, triglycerides. But insignificant change in serum glucose, urea nitrogen and uric acid levels were recorded. From the present study three things were concluded. Firstly, there is a strong relationship between level of DHEA and the progression of SLE. Secondly, liver activity and kidney functions were not affected by SLE disease.Thirdly, DHEA treatment has a beneficial effect on female patients. So this study recommended to follow up DHEAS in female patients and use it in a proper dosage. In addition, further study must be done.
Organizational Social Relations and Social Embedding: A Pluralistic Review

To date there has been little systematic organization of the extensive literature on the processes and mechanisms shaping social relationships in and around organizations. In an analysis of 372 studies from this literature, we identified a broad spectrum of assumptions, priorities, and relational issues emerging from multiple disciplines and theoretical lenses. Three dominant perspectives surfaced in our study: economic, organizational, and interactionist. Each manifests distinctive ontologies of social relations, actors, relational processes, and modes of social embedding. The rich variety of relationships and causal patterns discovered characterizes more fully these perspectives, suggesting opportunities for further research within each, and a wider range of conceptual options to target relational paradigms toward different types of organizations, problems, and levels of analysis. It also brings to light the pluralistic nature of social relations in organizational contexts and the processes by which they become embedded.
Similarity features, and their role in concept alignment learning

Finding mappings between compatible ontologies is an important and difficult open problem. Instance-based methods for solving this problem have the advantage of focussing on the most active parts of the ontologies and reflect the semantics of the ontologies as they are used in the real world. We evaluate how the feature representation of the instances is representative of the corresponding concepts, investigate how this corresponds with the domain characteristics of the data and which role it plays in the task of instance-based ontology mapping. We use two different competitive classifiers and a standard feature selection to identify important features, and study the effect of those different classifiers in the concept alignment context.
Causes of Undergraduate Students’ Underachievement in a Gulf Cooperation Council Country (GCC) University

UNESCO reports enrollment in higher education in the Arab and Gulf Cooperation Council region doubled from 5.1 million in 2000 to 10.7 million in 2015. Despite significant budgets and the world’s lowest teacher-to-student ratio, higher education in this region is plagued by student underachievement. This study identifies academic underachievement factors among undergraduate students at risk at a national university in the GCC. As part of the Intrusive Intervention Program, students were required to complete an Academic Success Plan that delineated academic, personal, social, career, and other academic underachievement reasons. Based on 5,040 students’ responses that indicated their academic underachievement causes, findings reported that students perceived academic factors as the most recurrent reason for academic underachievement. In contrast, social adjustment causes were found to be the least recurrent. Specific causes are reported under each category and discussion is provided against gender, nationality, major, and classification.
Microglial CD74 Expression Is Regulated by TGFβ Signaling

Simple Summary In the present study, we provided evidence that TGFβ signaling regulated the expression of the microglia activation marker CD74. Our data demonstrated that TGFβ1 inhibited LPS-induced upregulation of CD74. Moreover, inhibition of microglial TGFβ signaling in vitro and silencing of TGFβ signaling by deletion of Tgfbr2 in vivo resulted in marked upregulation of microglial CD74. Abstract Microglia play important roles during physiological and pathological situations in the CNS. Several reports have described the expression of Cd74 in disease-associated and aged microglia. Here, we demonstrated that TGFβ1 controled the expression of Cd74 in microglia in vitro and in vivo. Using BV2 cells, primary microglia cultures as well as Cx3cr1CreERT2:R26-YFP:Tgfbr2fl/fl in combination with qPCR, flow cytometry, and immunohistochemistry, we were able to provide evidence that TGFβ1 inhibited LPS-induced upregulation of Cd74 in microglia. Interestingly, TGFβ1 alone was able to mediate downregulation of CD74 in vitro. Moreover, silencing of TGFβ signaling in vivo resulted in marked upregulation of CD74, further underlining the importance of microglial TGFβ signaling during regulation of microglia activation. Taken together, our data indicated that CD74 is a marker for activated microglia and further demonstrated that microglial TGFβ signaling is important for regulation of Cd74 expression during microglia activation.
Research on 3D visualization simulation deformation analysis technology for hoisting of ultra-thin plate hull segments

Since the existing methods for the simulation and deformation analysis for ultra-thin plate hull segment hoisting are poorly specialized, and relying on experience is prone to deviations, it is difficult and inefficient to directly use finite element analysis. In response to the above problems, a 3D visualization simulation analysis method for deformation of ultra-thin plate hull segment hoisting is proposed, and special hoisting tools are designed to optimize the hoisting process. Based on the dynamic virtual simulation system specially designed for the hoisting of hull segments, the tensile force during the hoisting process of ultra-thin plate segments is obtained, and then combined with ANSYS software, the finite element analysis of the deformation during the hoisting process is carried out. The experimental results show that compared with the traditional hoisting process, the improved hoisting process in this paper can effectively control the stress and deformation of hull segments, realize the accurate simulation of the hoisting of the ultra-thin plate hull segments, and have a great reference significance for the actual hoisting process planning.
The Effect of Antecedents of Teachers’ Subjective Career Success

Career success is often seen as identical to objective matters such as high income and position. Meanwhile, one can see their success better when they build their own criteria of career success. In this regard, the present study aims to see the effect of internal (i.e., career commitment and professional commitment) and external variables (leader–member exchange and perceived organizational support) on teachers’ subjective career success. This quantitative study involved 320 teachers as participants, recruited using the accidental sampling technique. The data were collected using The Career Commitment Measure, Professional Commitment Scale, Leader–Member Exchange Multidimensionality, Survey of Perceived Organizational Support, and Subjective Career Success Inventory. The analysis result shows that career commitment, professional commitment, leader–member exchange, and perceived organizational support significantly affect teachers’ career success.
Prospective Drivers of Nurses’ Partial or Complete Retirement Seven Years Later: Work Ability and Physical Functioning Going against the Tide of Age

In the context of a nursing shortage in many developed countries, one option for retaining the expertise of older nurses in the workforce is to better manage the retirement of nurses. This study will investigate life course predictors of actual retirement behavior, whether partial or complete, for older working nurses over a seven-year span. Data were analyzed from a quantitative, longitudinal survey of 178 Australian nurses aged 45 years and older working at Time 1 (2012), who responded seven years later (Time 2). Age predicted both forms of retirement behavior, confirming the strength of social normative pressures toward retirement. Moving against this social normative tide toward retirement were the predictors of partial retirement such as job satisfaction, physical functioning and work ability. In turn, working part-time was the only predictor, beyond age, of complete retirement. Nurse and health service managers could support nurses to stand against the tide of social normative pressures (until such social norms change) by managing the nurses’ physical functioning and work ability, including by more explicitly managing the impacts of chronic diseases in the workplace, not least so as to retain their nurses in the context of nurse shortages.
Core decompression for early-stage avascular necrosis of the humeral head: current concepts and techniques

Avascular necrosis (AVN) of the humeral head is a rare, yet detrimental complication. Left untreated, humeral head AVN frequently progresses to subchondral fracturing and articular collapse. Cases of late-stage humeral head AVN commonly require invasive procedures including humeral head resurfacing, hemiarthroplasty, and total shoulder arthroplasty (TSA) to improve clinical outcomes. However, in cases of early-stage AVN, core decompression of the humeral head is a viable and efficacious short-term treatment option for patients with pre-collapse AVN of the humeral head to improve clinical outcomes and prevent disease progression. Several techniques have been described, however, a percutaneous, arthroscopic-assisted technique may allow for accurate staging and concomitant treatment of intraarticular pathology during surgery, although further long-term clinical studies are necessary to assess its overall outcomes compared with standard techniques. Biologic adjunctive treatments, including synthetic bone grafting, autologous mesenchymal stem cell/bone marrow grafts, and bone allografts are viable options for reducing the progression of AVN to further collapse in the short term, although long-term follow-up with sufficient study power is lacking in current clinical studies. Further long-term outcome studies are required to determine the longevity of core decompression as a conservative measure for early-stage AVN of the humeral head. Level of evidence IV.