Miracle-dz/UniFAR-FTUs huggingface dataset:
Research on IPv6 routing algorithm in WSN

Power saving is the most important problem in the WSN. All IPv6 datagrams transported in the WSN waste a lot of energy for transporting large packet header.Considering the characteristics of the IPv6 datagram,an algorithm for compressing IPv6 header was proposed,which can reduce the energy for sending packets,thus prolonging the lifetime of the nodes.
YOLO-Banana: A Lightweight Neural Network for Rapid Detection of Banana Bunches and Stalks in the Natural Environment

The real-time detection of banana bunches and stalks in banana orchards is a key technology in the application of agricultural robots. The complex conditions of the orchard make accurate detection a difficult task, and the light weight of the deep learning network is an application trend. This study proposes and compares two improved YOLOv4 neural network detection models in a banana orchard. One is the YOLO-Banana detection model, which analyzes banana characteristics and network structure to prune the less important network layers; the other is the YOLO-Banana-l4 detection model, which, by adding a YOLO head layer to the pruned network structure, explores the impact of a four-scale prediction structure on the pruning network. The results show that YOLO-Banana and YOLO-Banana-l4 could reduce the network weight and shorten the detection time compared with YOLOv4. Furthermore, YOLO-Banana detection model has the best performance, with good detection accuracy for banana bunches and stalks in the natural environment. The average precision (AP) values of the YOLO-Banana detection model on banana bunches and stalks are 98.4% and 85.98%, and the mean average precision (mAP) of the detection model is 92.19%. The model weight is reduced from 244 to 137 MB, and the detection time is shortened from 44.96 to 35.33 ms. In short, the network is lightweight and has good real-time performance and application prospects in intelligent management and automatic harvesting in the banana orchard.
Nuclear Localization Sequence of FGF1 Is Not Required for Its Intracellular Anti-Apoptotic Activity in Differentiated Cells

Fibroblast growth factor 1 (FGF1) is considered primarily as a ligand for FGF surface receptors (FGFRs) through which it activates a number of cellular responses. In addition to its canonical mode of action, FGF1 can act intracellularly, before secretion or after internalization and translocation from the cell exterior. The role of FGF1 inside the cell is to provide additional protection against apoptosis and promote cell survival. The FGF1 protein contains a specific N-terminal nuclear localization sequence (NLS) that is essential for its efficient transport to the nucleus. Here, we investigated the role of this sequence in the anti-apoptotic response of FGF1. To this end, we produced recombinant FGF1 variants with mutated or deleted NLS and added them to apoptosis-induced cells in which FGFR1 was inactive, either as a result of chemical inhibition or kinase-dead mutation. After internalization, all FGF1 variants were able to protect the differentiated cells from serum starvation-induced apoptosis. To verify the results obtained for NLS mutants, we knocked down LRRC59, a protein that mediates the nuclear transport of FGF1. Upon LRRC59 silencing, we still observed a decrease in caspase 3/7 activity in cells treated exogenously with wild-type FGF1. In the next step, FGF1 variants with mutated or deleted NLS were expressed in U2OS cells, in which apoptosis was then induced by various factors (e.g., starvation, etoposide, staurosporine, anisomycin and actinomycin D). Experiments were performed in the presence of specific FGFR inhibitors to eliminate FGFR-induced signaling, potentially activated by FGF1 proteins released from damaged cells. Again, we found that the presence of NLS in FGF1 is not required for its anti-apoptotic activity. All NLS variants tested were able to act as wild type FGF1, increasing the cell viability and mitochondrial membrane potential and reducing the caspase 3/7 activity and PARP cleavage in cells undergoing apoptosis, both transiently and stably transfected. Our results indicate that the nuclear localization of FGF1 is not required for its intracellular anti-apoptotic activity in differentiated cells and suggest that the mechanism of the stress response differs according to the level of cell differentiation.
Is Laterality Prognostic in Resected KRAS-Mutated Colorectal Liver Metastases? A Systematic Review and Meta-Analysis

Simple Summary Primary tumor laterality (PTL) is the most recently identified prognostic factor associated with mortality in patients with resected colorectal cancer liver metastases, but whether it is prognostic in all patients or only those with wild-type KRAS tumors is debated. The aim of this meta-analysis was to identify all relevant articles and synthesize their evidence to estimate the effect of PTL per KRAS mutational status. We found that PTL and KRAS mutational status have a statistically significant interaction. Specifically, PTL has a variable effect in patients with wild-type versus KRAS-mutated tumors, with right-sided tumors associated with worse survival only in the former. This meta-analysis appears to resolve a long-lasting debate. Abstract Background: It is debated whether primary tumor laterality (PTL) is prognostic in all patients with colorectal liver metastases (CRLM) or only those with KRAS wild-type or KRAS-mutated tumors; Methods: We systematically reviewed PubMed for studies reporting on resected CRLM originating from left-sided (LS) versus right-sided (RS) colon cancer stratified by KRAS status. Individual participant data (IPD) were used if available. Given that there are two definitions of PTL, we performed two meta-analyses for KRAS-mutated and two for wild-type patients. To assess if an interaction underlies the possible difference between the effects of PTL in KRAS-mutated vs. wild-type CRLM, we similarly performed two meta-analyses of interaction terms; Results: The meta-analyses included eight studies and 7475 patients. PTL had a prognostic association with OS in patients with wild-type tumors (HR for LS: 0.71 [0.60–0.84]), but not in those with KRAS-mutated tumors (HR: 0.99 [0.82–1.19]). This difference stemmed from a truly variable effect of PTL for each KRAS status (mutated vs. wild-type) as the meta-analysis of interaction terms showed a significant interaction between them (HR:1.38 [1.24–1.53]). Similar results were obtained when the second definition of PTL (LS to not include the rectum) was used; Conclusions: KRAS status modifies the association of tumor site with survival. Right-sided tumors are associated with worse OS only in patients with wild-type CRLM.
ITAE Controller Design and Simulation for Electric Load Simulator Based on Genetic Algorithm

During the design of the control system of electric load simulator,the optimal controller parameters are generally determined by lots of experiments.In this paper,according to the operating principle of the electric load simulator,the mathematic model of its actuating mechanism is built.Then,the joint stiffness between the electric load simulator and the rudder is analyzed which can influence the system performance.Based on the analysis result,the low joint stiffness should be selected under the condition of satisfying constraint of system close loop responding.Next,combining with the load gradient,the structure of composite controller is designed by choosing suitable joint stiffness.And,the parameters of composite controller are optimized by using genetic algorithm in accordance with the absolute value of error(ITAE) criterion.Last,the simulation and experiments result show that the controller can not only make the steady error of the closed loop less than 0.5%,but also make the error of amplitude less than 10% and the error of phase less than 10 degree when system is stimulated by 10Hz sine signal.
Dynamic Simulation of Ballscrew's Ball-returning Circulatory System Based on ADAMS

This paper researches into ball-returning curve theoretical mode and builds the ball-returning device 3D mode by the Pro/E software.The interface software is used to transfer the ballscrew assembly CAD mode from Pro/E to ADAMS and according to the Hertz contact theory and impulse function mode,the dynamic simulation mold is set up in ADAMS.Through this simulation we can get the change of energy and impact force when the balls are in and out the ball-returning device.These data can supply guidance basis for the optimization ball-returning curve.
Optimization of Process Based on Adaptive Ant Colony Algorithm

To solve the optimal process planning problem in the computer aided process planning,an optimal process planning method based on adaptive ant colony algorithm(AACA) and taken minimal replacement rate of manufacturing resources as optimization objective is proposed.The manufacturing feature is sub-divided into manufacturing procedures according accuracy requirement,and then the concept of machining cell which is composed of manufacturing feature,manufacturing procedure,manufacturing method,manufacturing resource and fixing location is introduced.Therefore the process planning could be represented by an optimal arrangement to the machining cells.A matrix of constraints to Machining cells is constructed according the constraints of geometrical location among manufacturing features and the priority among manufacturing procedures.The least replacement rate of manufacturing resources,which represent unified seeking for less time-to-market,higher quality and lower cost,is taken as the optimization objective.Under the constraints of the matrix of constraints to machining cells and the available manufacturing resources,the AACA is adopted to solve the model.An example is given to demonstrate that our method is reliable and effective to produce the process plan in accordance with the real practice.
Study on the Screening of Salt-tolerant Watermelon Stock and Mechanism of Salt-tolerance

Salt-tolerant watermelon stock suit for greenhouse culture was successfully isolated through NaCl stress, and the mechanism of salt-tolerance of stock was studied. The results showed that the salt tolerant of sanfeng guard and Beijing very earlierness was guard were the best, and their ultimate salt tolerant concentration was 300 mmol/L, but hanyu guard was on the contrary. Under the high salt stress,the structure of membrance was destroyed,permeability of cytoplasm membrance was enhanced,electrolytic leakage was increased rapidly;membrance lipid peroxidation was hasten,and content of MDA was dramatically increased,POD activities raised and SOD activities declined.At the same time,content of proline was approved.
Opportunities for the development of ecological competence of the future preschool teachers

The preschool period plays a key role in environmental education and shaping attitudes towards the environment. It is therefore important that preschool teachers are equipped to provide students with the necessary training in their early stages. This study aims to evaluate the new opportunities for the development of the ecological competencies of future preschool teachers in terms of the views of pre-service teachers. This research was conducted using a qualitative design. The participants of the research consisted of 33 students studying in the 3rd and 4th grades of the preschool teaching department at various universities in Kazakhstan in the 2021-2022 academic year. As a data collection tool, the researchers created a semi-structured interview form. From the result of the research, pre-school teacher candidates found themselves at a medium level in terms of ecological competencies. Pre-school teacher candidates evaluated ecological attitudes and behaviors in the categories of environmental awareness, sensitivity, and volunteerism. Keywords: Ecological competencies; pre-school; teacher candidates
Research on Dynamics Performance of High Speed Trains under Strong Lateral Wind

In view of the operation safety of high speed passenger trains under strong lateral wind,the 3-car three dimensional dynamics simulation model is set up with the use of the SIMPACK software.On the basis of the wind load data obtained in the aerodynamics simulation calculation for existing high speed trains under lateral wind,the effect of lateral wind on the dynamics performance of trains on tangent lines and curves is analyzed.The results show that the wheel-rail indexes of the train such as wheel-rail lateral force,derailment coefficient and reduction rate of wheel load have all increased obviously,and the maximum values all appear in the head car.In the end,the referential values of the maximum permissible speeds of trains on tangent lines and curves under several typical air speeds are obtained.
Risk-Neutral Market Simulation

We develop a risk-neutral spot and equity option market simulator for a single underlying, under which the joint market process is a martingale. We leverage an efficient low-dimensional representation of the market which preserves no static arbitrage, and employ neural spline flows to simulate samples which are free from conditional drifts and are highly realistic in the sense that among all possible risk-neutral simulators, the obtained risk-neutral simulator is the closest to the historical data with respect to the Kullback-Leibler divergence. Numerical experiments demonstrate the effectiveness and highlight both drift removal and fidelity of the calibrated simulator.
Performance Evaluation of BD FACSPrestoTM Near-Patient CD4 Counter for Monitoring Antiretroviral Therapy in HIV-Infected Individuals in Primary Healthcare Clinics in Thailand

HIV viral load is more reliable tool for monitoring treatment throughout the course of HIV/AIDS, but the test may be expensive in resource-limited settings. Therefore, enumeration of CD4 T-lymphocyte count remains important in these settings. This study evaluated the performance of BDFACSPresto, a near-patient CD4 counter planned to be used in primary healthcare clinics in Thailand. Results of percent, absolute CD4 count and hemoglobin (Hb) on the FACSPresto were compared with the TriTEST/TruCOUNT/BDFACSCalibur method and a Sysmex hematology analyzer. Phase I of the study was performed in an ISO15189 laboratory. Both percentage and absolute values showed Passing–Bablok slopes within 0.98–1.06 and 0.97–1.13, mean Bland–Altman biases of +1.2% and +20.5 cells/µL, respectively. In phase II, venous and some capillary blood samples were analyzed in four primary healthcare clinics. The results showed good correlation between capillary and venous blood. For venous blood samples, regression lines showed slopes of 1.01–1.05 and 1.01–1.07 for all percentage and absolute values. The overall mean biases were +0.9% and +17.0 cells/µL. For Hb, Passing–Bablok regression result gave slope within 1.01–1.07 and mean bias of −0.06 g/dL. Thus, CD4 enumeration in blood by the FACSPresto is reliable and can be performed to an identical standard at primary healthcare clinics.
Mitigative Effects of PFF-A Isolated from Ecklonia cava on Pigmentation in a Zebrafish Model and Melanogenesis in B16F10 Cells

Melanin synthesis is a defense mechanism that prevents skin damage, but excessive accumulation of melanin occurs in the skin in various reactions such as pigmentation, lentigines, and freckles. Although anti-melanogenic effects have been demonstrated for various naturally occurring marine products that inhibit and control tyrosinase activity, most studies have not been extended to in vivo applications. Phlorofucofuroeckol-A (PFF-A, 12.5–100 µM) isolated from Ecklonia cava has previously been shown to have tyrosinase-mitigative effects in B16F10 cells, but it has not been evaluated in an in vivo model, and its underlying mechanism for anti-melanogenic effects has not been studied. In the present study, we evaluated the safety and efficacy of PFF-A for anti-melanogenic effects in an in vivo model. We selected low doses of PFF-A (1.5–15 nM) and investigated their mitigative effects on pigmentation stimulated by α-MSH in vivo and their related-mechanism in an in vitro model. The findings suggest that low-dose PFF-A derived from E. cava suppresses pigmentation in vivo and melanogenesis in vitro. Therefore, this study presents the possibility that PFF-A could be utilized as a new anti-melanogenic agent in the cosmeceutical industries.
Marginal Fit Evaluation of Zirconia and Polyetheretherketone Inlay Retained Fixed Partial Dentures Fabricated with CAD-CAM

Purpose: The purpose of this study was to compare marginal fit of Zirconia and Polyetheretherketone (PEEK) inlay retained fixed partial dentures (IRFPD) fabricated by using a computer-aided design and computer-aided manufacturing (CAD-CAM) system. Materials and Methods: Sound Mandibular second premolar and mandibular second molar were selected to simulate a clinical situation of a missing mandibular first molar and embedded in an epoxy resin (master model). Both teeth received a standard preparation of IRFPD with respect to all-ceramic preparation design parameters. The master model was duplicated into 18 epoxy resin models for standardization during testing procedure, and 18 IRFPDs were fabricated with CAD-CAM system and divided into 2 groups according to materials type (n=9); Group 1: 3-mol yttria-stabilized tetragonal zirconia polycrystal (3Y-TZP), Group 2: PEEK. Marginal Discrepancy of all bridges was tested before and after cementation with RelyX U200 self-adhesive resin cement (SARC) by using an optical digital microscope with the aid of an image analysis system. Results: Significantly lower marginal gap values were obtained in Zirconia group before and after cementation in comparison to PEEK group. There was also a significant increase of marginal gap after cementation in both groups, with higher mean in Zirconia group. Conclusion: The margins of IRFPDs performed well with recommended bonding protocols for both materials and present a viable treatment option for replacing a missing single posterior tooth. Both materials presented clinically accepted results of marginal discrepancy less than 120 μm. Further studies simulating clinical conditions are needed to understand how they perform in function. Codex : 03/22.01 azhardentj@azhar.edu. eg http://adjg.journals. ekb.eg DOI: 10.21608/adjg.2021. 48254.1318 Restorative Dentistry (Removable Prosthodontics, Fixed Prosthodontics, Endodontics, Dental Biomaterials, Operative Dentistry)
The Transient Sea Level Response to External Forcing in CMIP6 Models

Earth is warming and sea levels are rising as land‐based ice is lost to melt, and oceans expand due to accumulation of heat. The pace of ice loss and steric expansion is linked to the intensity of warming. How much faster sea level will rise as climate warms is, however, highly uncertain and difficult to model. Here, we quantify the transient sea level sensitivity of the sea level budget in both models and observations. Models show little change in sensitivity to warming between the first and second half of the twenty‐first century for most contributors. The exception is glaciers and ice caps (GIC) that have a greater sensitivity pre‐2050 (2.8 ± 0.4 mm/yr/K) compared to later (0.7 ± 0.1 mm/yr/K). We attribute this change to the short response time of glaciers and their changing area over time. Model sensitivities of steric expansion (1.5 ± 0.2 mm/yr/K), and Greenland Ice Sheet mass loss (0.8 ± 0.2 mm/yr/K) are greater than, but still compatible with, corresponding estimates from historical data (1.4 ± 0.5 and 0.4 ± 0.2 mm/yr/K). Antarctic Ice Sheet (AIS) models tends to show lower rates of sea level rise (SLR) with warming (−0.0 ± 0.3 mm/yr/K) in contrast to historical estimates (0.4 ± 0.2 mm/yr/K). This apparent low bias in AIS sensitivity is only partly able to account for a similar low bias identified in the sensitivity of global mean sea level excluding GIC (3.1 ± 0.4 vs. 2.3 ± 0.4 mm/yr/K). The balance temperature, where SLR is zero, lies close to the pre‐industrial value, implying that SLR can only be mitigated by substantial global cooling.
Theoritical Analysis and Experimental Study of Oil Atomizing in a Single Screw Compressor

In order to decrease air leakage, oil or other liquids must also be injected into compression cavity of a single screw compressor as other rotary compressors must. The injected oil can decrease the leakage and the discharge temperature of air. But it increases the losses in such as viscosity shearing, friction, stirring and intake preheating, and influences the performance of the compressor directly. Based on oil atomizing theory, the parameter of Weber mumber is put forward for evaluating the atomizing level of the oil in compression cavity. The volumetric and adiabatic efficiencies of a single screw compressor are obtained at different oil injection volumes, temperatures and injecting hole diameters. The analysis of the experimental results shows that it is possible to select oil injection parameters according to Weber number, and the Weber number of the compressor used in the experiment should be greater than 60.
Ten years of experience with ecological connectivity analysis and urban planning in Sweden

ABSTRACT The use of quantitative analysis and related metrics has traditionally been unusual for assessment of ecological impacts in urban planning. Since 2010, however, quantitative modelling has been increasingly used in such contexts in Sweden to analyze ecological connectivity. The study reviews and analyses 21 connectivity analysis reports (CAR) based on 17 criteria. Despite the use of quantitative analysis, CARs primarily leverage qualitative aspects of modelling results. Most CARs comply with about 50% of the proposed criteria and close to 90% of the reports fail to address some issues related to modelling transparency and therefore jeopardize an adequate ecological interpretation of the results. The results demonstrate that the primary accomplishment during the last decade is an increase in awareness and acceptance of ecological connectivity among practitioners and decisionmakers. Results point to that an increased use of quantitative methods per se will not deliver more sustainable outcomes, and that an increased use of quantitative methods for ecological impact assessment in urban planning needs to be accompanied by guidelines, standards, and a continuous science – practice knowledge exchange.
Dynamic Control Model for Secondary Cooling Zone of Slab Caster

According to the theory of heat transfer and solidification, a mathematical model used for secondary cooling zone of slab caster was established. The influence of space and time pacing on the result of numerical calculation was studied. A dynamic tracing program and a new control model using the virtual casting speed as control parameter was developed. The dynamic tracking program of secondary cooling was used to simulate the casting with varied speed. The results show that the virtual casting speed control model is superior to the actual casting speed control model.
Effect of camel milk and its derivatives on triglycerides and cholesterol level in alloxan-induced diabetic rabbits

This trial aimed to find out the effect of camel milk and its derivatives on triglycerides and cholesterol levels in Alloxan-Induced diabetic rabbits. Diabetes was induced by intravenous injection of Alloxan solution. The diabetic rabbits were treated with fresh and fermented camel milk and colostrums for 60 days. The results demonstrated that triglycerides and cholesterol levels were reduced throughout the experimental period when using camel milk and its derivatives and the levels were kept within the accepted ranges.