Miracle-dz/UniFAR-FTUs huggingface dataset:
Virtual reality and data analysis based platform for urban mobility awareness as a tool for road education

The constant growth of public and private transport can be understood as a fundamental pillar for the development of integrated mobility systems, as it is giving way to an expansion and improvement of the way people move and, therefore, generating a better quality of life. However, road education and awareness of traffic and transport regulations are at a critical point, because its dissemination needs to cover an increasing number of people, both in urban and rural areas. Conversely, it is known that the development of information and communication technologies (ICTs) has made it possible to globalize Internet access and services from government entities to citizens, so its integration with public mobility, transit, and transport companies is of vital importance. Consequently, this article discusses a proposal to generate a road education platform for Conscious Urban Mobilization (MUC) developed by the Universidad Politécnica Salesiana (UPS) and the Empresa Publica Municipal de Movilidad, Tránsito y Transporte (EMOV EP) of the city of Cuenca (MUC-UPS-EMOV). In this way, it seeks to address two specific objectives: i) the development of virtual reality (VR) systems for learning transport and transit rules through serious games; and, ii) the creation of a mobility web observatory for disseminating information through digital activism, and data visualization and analysis. In addition, prototypes of the VR systems that will be part of MUC-UPS-EMOV are presented, which are based on the analysis of the traffic accidents that occurred during the years 2017 and 2019 within the city of Cuenca.
Small incision lenticule extraction retreatment in a patient with high residual refractive error after photorefractive keratectomy: A case report

A 36-year-old male underwent uneventful small incision lenticule extraction (SMILE) for the correction of his high residual refractive error 12 years after photorefractive keratectomy (PRK). Preoperatively, uncorrected distance visual acuity (UDVA) was counting fingers in both eyes. Corrected distance visual acuity was 20/20 in the right and 20/30 in the left eye due to amblyopia. One month after SMILE, UDVA was 20/20 and 20/30 in the right and left eye, respectively; post-PRK corneal haze had reduced. During the 4-year follow-up, UDVA remained stable and there were no complications. SMILE could be a good alternative approach for retreatment in post-PRK patient.
Visualizing RNA Cytidine Acetyltransferase Activity by Northern Blotting

Cytidine acetyltransferases are an emerging class of nucleic‐acid‐modifying enzymes responsible for the establishment of N4‐acetylcytidine (ac4C) in RNA. In contrast to histone acetyltransferases, whose activity is commonly studied by western blotting, relatively few methods exist for quickly assessing the activity of cytidine acetyltransferases from a biological sample of interest or the distribution of ac4C across different RNA species. In this protocol, we describe a method for analysis of cellular cytidine acetyltransferase activity using dot‐ and immuno‐northern‐blotting‐based detection. © 2020 Wiley Periodicals LLC.
Continuous High‐Throughput Fabrication of Architected Micromaterials via In‐Air Photopolymerization

Recent advances in optical coding, drug delivery, diagnostics, tissue engineering, shear‐induced gelation, and functionally engineered rheology crucially depend on microparticles and microfibers with tunable shape, size, and composition. However, scalable manufacturing of the required complex micromaterials remains a long‐standing challenge. Here in‐air polymerization of liquid jets is demonstrated as a novel platform to produce microparticles and microfibers with tunable size, shape, and composition at high throughput (>100 mL h−1 per nozzle). The polymerization kinetics is quantitatively investigated and modeled as a function of the ink composition, the UV light intensity, and the velocity of the liquid jet, enabling engineering of complex micromaterials in jetting regimes. The size, morphology, and local chemistry of micromaterials are independently controlled, as highlighted by producing micromaterials using 5 different photopolymers as well as multi‐material composites. Simultaneous optimization of these control parameters yields rapid fabrication of stimuli‐responsive Janus fibers that function as soft actuators. Finally, in‐air photopolymerization enables control over the curvature of printed droplets, as highlighted by high‐throughput printing of microlenses with tunable focal distance. The combination of rapid processing and tunability in composition and architecture opens a new route toward applications of tailored micromaterials in soft matter, medicine, pharmacy, and optics.
Prevalence of Postoperative Pain Following Hospital Discharge: Protocol for a Systematic Review

Background Pain is one of the most common, feared, and unpleasant symptoms associated with surgery. However, there is a clear gap in patient care after surgical patients are discharged from hospital, resulting in poorly controlled postoperative pain. Inadequate pain management after discharge can have detrimental effects on quality of life and lead to the development of chronic postsurgical pain. The severity of postoperative pain before discharge is well described, but less emphasis has been placed on assessing pain at home after hospital discharge. Objective The objective of this review is to summarize the prevalence of moderate-to-severe postoperative pain within the first 1 to 14 days after hospital discharge. Methods A detailed search of epidemiological studies investigating postoperative pain will be conducted on MEDLINE and EMBASE from their inception until the date the searches are run. The primary outcome will be the proportion of patients reporting moderate-to-severe postoperative pain at rest and with movement within the first 1 to 14 days after hospital discharge. The secondary outcomes will include a comparison of postoperative pain after discharge between patients who underwent ambulatory and inpatient surgery, and adverse outcomes attributable to poor pain control after hospital discharge (eg, readmission to hospital, emergency room or other unplanned medical visits, or a decrease in quality of life). Results The protocol has been registered in PROSPERO (registration number CRD42020194346). The search strategies for MEDLINE and EMBASE have been completed. The final results are expected to be published in May 2021. Conclusions This systematic review is expected to synthesize evidence describing the prevalence of postoperative pain after hospital discharge. Available epidemiological evidence may help inform the magnitude of the problem of postoperative pain at home after hospital discharge. Trial Registration PROSPERO International Prospective Register of Systematic Reviews CRD42020194346; https://www.crd. york.ac. uk/prospero/display_record. php? RecordID=194346 International Registered Report Identifier (IRRID) PRR1-10.2196/22437
Design of a Track-Leg Hybrid Locomotive Mobile Robot

The use of robotic platforms for operations in harsh and high risk environments such as mining sites has become more popular with the advancements within the field of mobile robotics. In this paper, the designing of a hybrid locomotive mobile platform that utilizes both tracked locomotion and legged-like movements to achieve mobility is presented. The proposed track-leg mechanism and power transmission methodology are discussed in detail along with the overall design framework. The functionality validation and analysis of the legged locomotion was done in a simulation environment using MSC ADAMS with open-loop track-leg velocity control. The designed mobile robot demonstrated the ability to traverse a flat terrain and overcome a semi-cylindrical obstacle without tipping over in the simulations for the selected gait. The mobile robot also consists of 3 degrees of freedom (DOF) robotic arm which facilitates total human replacement by enabling the ability to perform any sample collecting, inspecting, pick and place tasks. The design of the robotic arm is also presented within this paper.
Difference-Guided Representation Learning Network for Multivariate Time-Series Classification

Multivariate time series (MTSs) are widely found in many important application fields, for example, medicine, multimedia, manufacturing, action recognition, and speech recognition. The accurate classification of MTS has become an important research topic. Traditional MTS classification methods do not explicitly model the temporal difference information of time series, which is, in fact, important and reflects the dynamic evolution information. In this article, the difference-guided representation learning network (DGRL-Net) is proposed to guide the representation learning of time series by dynamic evolution information. The DGRL-Net consists of a difference-guided layer and a multiscale convolutional layer. First, in the difference-guided layer, we propose a difference gating LSTM to model the time dependency and dynamic evolution of the time series to obtain feature representations of both raw and difference series. Then, these two representations are used as two input channels of the multiscale convolutional layer to extract multiscale information. Extensive experiments demonstrate that the proposed model outperforms state-of-the-art methods on 18 MTS benchmark datasets and achieves competitive results on two skeleton-based action recognition datasets. Furthermore, the ablation study and visualized analysis are designed to verify the effectiveness of the proposed model.
A synthesis inversion of the concentration and δ 13 C of atmospheric CO 2

A synthesis inversion technique is used to estimate CO 2 fluxes to and from the atmosphere. Concentrations calculated by the GISS atmospheric tracer transport model are fitted to observations of CO 2 and 13 CO 2 . The procedure uses the uncertainty in the data to derive measures of uncertainty for the estimated sources, thus allowing a comparison of the relative importance of various data items in reducing these uncertainties. We analysed two periods. The first, 1986-1987, was intended to be representative of these and earlier years. The CO 2 data appear generally representative but the inversion produces some features that may reflect El Nino conditions. The second period was 1989-1990 which had anomalous behaviour in δ 13 C. The attempt to analyse 1989-1990 was somewhat unsatisfactory, apparently because the assumption of a quasi-steady state, required by our analysis, was not satisfied sufficiently well. The main result is that global totals of oceanic versus biotic exchange are constrained primarily by the global trends of CO 2 and 13 CO 2 . The transport model constrains the regional sources and sinks but these constraints make only a small contribution to reducing the uncertainty in the global budget. We find that within the range of ≈ 1.2 Gt C y -1 our unconstrained estimates of air-sea flux are very sensitive to the choice of data that are fitted. This confirms the appropriateness of our formal error estimates based on a priori statistics. DOI: 10.1034/j.1600-0889.47. issue1.5. x
The effect of egg size (weight) on the egg shell thickness, egg yolk and hatchabilty in Koekoek chickens

The aim of this study was to determine the effect of egg size on egg shell, egg yolk, fertility rate and hatchability of Koekoek chickens. A Complete Randomized Design (CRD) was used with egg size being the treatment factor. The treatments were large (>55g), medium (45-54g) and small (<44g) sized eggs. Eggs were collected from the nests and weighed using the digital scale and classified according to their respective weights before incubation. The egg yolk weight was measured with the digital scale. The shell thickness was measured using a Vanier caliper. The fertile and infertile eggs were identified. The fertility rate, hatching percentage and embryonic mortality were recorded. Data collected was subjected to statistical analysis by using one way analysis of variance (ANOVA). The medium sized eggs had higher fertility and hatchability percentage compared to large and small sized eggs. The mortality was higher in large and small sized eggs. Therefore, select eggs at the range of 45 to 55 grammes for incubation can be useful to increasing hatchability.
Application of Square-wave Pulse Heat Method to Thermal Properties Measurement of CaO–SiO2–Al2O3 System Fluxes

The square-wave pulse heat method was improved to measure thermal properties of vitreous samples by considering radiation heat transfer between the front and back faces of the samples, and the measurement accuracy of the method was examined.Thermal properties of CaO–SiO2–Al2O3 samples were measured by the method. Thermal diffusivities of the crystalline 40CaO–40SiO2–20Al2O3 (mol%) sample are about 1.5–2.5 times larger than those of the vitreous sample. Specific heat of the crystalline and vitreous samples shows almost the same temperature dependency, except the highest measurement temperature due to crystallization of glass.Finally, we investigated the reason that the thermal conductivity values measured by the improved square-wave pulse heat method differ from those by the line source method. As a result, crystallization of glass during the measurements would cause the difference of the temperature dependencies of the values measured by the two methods.
Silver single-atom catalyst for efficient electrochemical CO2 reduction synthesized from thermal transformation and surface reconstruction.

Herein, we report an Ag 1 single-atom catalyst (Ag 1 /MnO 2 ), which was synthesized from thermal transformation of Ag nanoparticles (NPs) and surface reconstruction of MnO 2 . The evolution process of Ag NPs to single atoms is firstly revealed by various techniques including in-situ ETEM, in-situ XRD and DFT calculations. The temperature-induced surface reconstruction process from MnO 2 (211) to (310) lattice plane is critical to firmly confine the existed surface of Ag single-atom, i.e. the thermal treatment and surface reconstruction of MnO 2 is the driving force for the formation of single Ag atoms. The as-obtained Ag 1 /MnO 2 achieved 95.7% Faradic efficiency at -0.85 V vs. RHE, and coupled with long-term stability for electrochemical CO 2 reduction reaction (CO 2 RR). DFT calculations indicated single Ag sites possessed high electronic density close to Fermi Level and could act as the only active sites in CO 2 RR. As a result, the Ag 1 /MnO 2 catalyst shows remarkable performance for CO 2 RR, far surpassing the conventional Ag nanosized catalyst (Ag NP /MnO 2 ) and other reported Ag-based catalysts.
Retrospective Study of Rehabilitation Exercise Combined with Extracorporeal Shock Wave Therapy for Knee Osteoarthritis

Background The aim of this study was to investigate the effect of rehabilitation exercise combined with extracorporeal shock wave therapy (ESWT) on knee osteoarthritis (KOA). Material/Methods The clinical data of 217 patients with KOA who underwent ESWT in our hospital from December 2017 to January 2020 were retrospectively analyzed. The patients were divided into a rehabilitation exercise (RE) group and a non-rehabilitation exercise (NRE) group according to whether they were given RE. The treatment course of the 2 groups was 5 weeks. Pain Visual Analog Scale (VSA), Western Ontario and McMaster Universities knee osteoarthritis index visualized scale (WOMAC), Lequesne index scores, Range of motion (ROM) score, and Japanese Orthopaedic Association (JOA) scores were used to evaluate the treatment effect of the 2 groups of patients. Results After 5 weeks of treatment, the VSA scores (p<0.001), WOMAC scores (P<0.001) and Lequesne index scores (P<0.001) of the RE group and NRE group were significantly lower than those before treatment, while ROM score (P<0.001) and JOA score (p=0.006) were significantly increased. Compared with the NRE group, the VAS score (3.14±0.64 vs. 4.78±0.85, P=0.002), WOMAC score (20.37±4.06 vs. 27.82±4.57, P<0.001) and Lequesne index score (6.13±1.83 vs. 7.35±2.21, P=0.019) in the RE group were significantly lower than those in the NHE group; however, the ROM score (89.13±9.83 vs. 79.15±6.25, P=0.021) and JOA score (79.53±7.59 vs. 67.85±8.27, P=0.016) were significantly higher than those in the NRE group. Conclusions RE combined with ESWT has a positive effect on KOA, which may more significantly relieve the patient’s clinical symptoms and improve joint function and quality of life.
Central-most Visual Field Defects in Early Glaucoma.

PRéCIS:: This study demonstrates the substantial association between visual field defect within the central-most 4 points in 24-2VF and the visual field defect exhibited by 10-2 test pattern relative to the initial defect in 24-2VF. PURPOSE To evaluate the significance of central-most visual field defects (CMVFD) in 24-2 visual fields (VF) in early glaucoma. METHOD This cross-sectional study examined 29 eyes of 28 glaucoma patients with CMVFDs. CMVFD was defined as a glaucomatous defect with at least 1 abnormal point at P<1% within the central 5° on 3 consecutive 24-2 VF tests. 10-2VFs were categorized into 3 groups by severity of pattern defects: deep arcuate, partial arcuate, and minimal defect. The deep arcuate group was interpreted as the most severe defect on the 10-2 VF. Mann-Whitney test was used to compare the perimetric parameters differences between 24-2VFs with CMVFD and 10-2VFs related to the initial defect. RESULTS CMVFD was observed in 82% eyes, predominantly in the superior hemifield (86%). Arcuate-like defects(72%) on the 10-2 VF were mostly in superior hemifield (82%). The deep arcuate group showed significantly worse MD and PSD (MD= -9.1±4, PSD=10.7±2.1▒dB) than partial arcuate and minimal defect groups(all P<0.001). Eyes with deep arcuate defect had severely depressed defect depth (-26▒dB to -35▒dB) and low sensitivity (<0▒dB to10▒dB) at abnormal points in the central 5° in 24-2VF.A significant difference among deep arcuate, partial arcuate (P<0.001) and minimal defect groups (P<0.001) was observed at abnormal points' threshold sensitivity and defect depth. CONCLUSION Given the significance and effect of perimetric factors at abnormal test points in the central 5° of 24-2 VFs, these eyes deserve attention to determine the severity of and functional impact on the central-most visual field defects in early glaucoma by performing 10-2 test.
Geometric Stability, Electronic Structure and Reactivity of Pt4 Cluster Supported on Defective Graphene

The geometric stability, electronic structure and magnetic properties of the Pt4 clusters on graphene substrates are investigated using the first-principles methods. It is found that the Pt4 clusters on the defective graphene with a single vacancy defect (SV-graphene) have larger binding energies than that on the pristine graphene. The different position of SV sites can modulate the geometric stability of Pt4 clusters. The Pt4 clusters provide more transferred electrons to the SV-graphene and exhibit the positively charged, which helps to weaken the CO adsorption. The results would be important for understanding that the adsorption behavior of metal clusters on graphene.
Exploratory study to understand association of emotional comorbidities and sleep with migraine

Abstract Background Migraine is often associated with psychiatric and emotional co-morbidities. Several studies have shown association of sleep problems and/or emotional co-morbidities among migraineurs. However, less is known about the association of migraine disability with sleep and emotional co-morbidities. Objective To explore the association of emotional co-morbidities and sleep quality with migraine disability among migraineurs in the central part of India. Methods and material A cross-sectional study enrolling 132 patients of migraine was conducted at a tertiary care centre. They were evaluated for migraine disability by Migraine Disability Assessment Test (MIDAS), emotional co-morbidities by depression, anxiety, stress scale (DASS-21) and sleep quality by Pittsburgh Sleep Quality Index (PSQI). Result Mean age of participants was 32.9 ± 9.8 and 83.3% (n = 110) were females. Fourty seven percentage(n = 62) patients reported moderate to severe disability on MIDAS. Anxiety was most frequent (n = 87; 65.9%) emotional co-morbidity followed by depression (n = 70;53%) and stress (n = 52;39.4%). Severity of emotional co-morbidities increased while sleep quality deteriorated with increasing migraine disability. However, migraine frequency had positive correlation only with sleep quality. Stress showed a linear relationship with migraine disability at highest second–third decile of MIDAS. Conclusion Migraineurs in central India have higher emotional co-morbidities. These co-morbidities increased and sleep quality deteriorated with increasing migraine disability. Frequency of migraine has no association with emotional co-morbidities. Linear association of stress at higher migraine disability prompts possible role of stress management to break the complex relationship between stress and migraine.
Non-Coding RNAs and SARS-Related Coronaviruses

The emergence of SARS-CoV-2 in 2019 has caused a major health and economic crisis around the globe. Gaining knowledge about its attributes and interactions with human host cells is crucial. Non-coding RNAs (ncRNAs) are involved in the host cells’ innate antiviral immune response. In RNA interference, microRNAs (miRNAs) may bind to complementary sequences of the viral RNA strand, forming an miRNA-induced silencing complex, which destroys the viral RNA, thereby inhibiting viral protein expression. There are several targets for human miRNAs on SARS-CoV-2’s RNA, most of which are in the 5’ and 3’ untranslated regions. Mutations of the viral genome causing the creation or loss of miRNA binding sites may have crucial effects on SARS-CoV-2 pathogenicity. In addition to mediating immunity, the ncRNA landscape of host cells further influences their susceptibility to virus infection, as certain miRNAs are essential in the regulation of cellular receptors that are necessary for virus invasion. Conversely, virus infection also changes the host ncRNA expression patterns, possibly augmenting conditions for viral replication and dissemination. Hence, ncRNAs typically upregulated in SARS-CoV-2 infection could be useful biomarkers for disease progression and severity. Understanding these mechanisms could provide further insight into the pathogenesis and possible treatment options against COVID-19.