Miracle-dz/UniFAR-FTUs huggingface dataset:
A genome‐wide quantitative trait locus (QTL) linkage scan of NEO personality factors in Latino families segregating bipolar disorder

Personality traits have been suggested as potential endophenotypes for Bipolar Disorder (BP), as they can be quantitatively measured and show correlations with BP. The present study utilized data from 2,745 individuals from 686 extended pedigrees originally ascertained for having multiplex cases of BP (963 cases of BPI or schizoaffective BP). Subjects were assessed with the NEO Personality Inventory, Revised (NEO PI‐R) and genotyped using the Illumina HumanLinkage‐24 Bead Chip, with an average genetic coverage of 0.67 cM. Two point linkage scores were calculated for each trait as a quantitative variable using SOLAR (Sequential Oligogenic Linkage Analysis Routines). Suggestive evidence for linkage was found for neuroticism at 1q32.1 (LOD = 2.52), 6q23.3 (2.32), 16p12 (2.79), extraversion at 4p15.3 (2.33), agreeableness at 4q31.1 (2.37), 5q34 (2.80), 7q31.1 (2.56), 16q22 (2.52), and conscientiousness at 4q31.1 (2.50). Each of the above traits have been shown to be correlated with the broad BP phenotype in this same sample. In addition, for the trait of openness, we found significant evidence of linkage to chromosome 3p24.3 (rs336610, LOD = 4.75) and suggestive evidence at 1q43 (2.74), 5q35.1 (3.03), 11q14.3 (2.61), 11q21 (2.30), and 19q13.1 (2.52). These findings support previous linkage findings of the openness trait to chromosome 19q13 and the agreeableness trait to 4q31 and identify a number of new loci for personality endophenotypes related to bipolar disorder.
A Detailed Molecular Belt Model for Apolipoprotein A-I in Discoidal High Density Lipoprotein*

Apolipoprotein A-I (apoA-I) is the principal protein of high density lipoprotein particles (HDL). ApoA-I contains a globular N-terminal domain (residues 1–43) and a lipid-binding C-terminal domain (residues 44–243). Here we propose a detailed model for the smallest discoidal HDL, consisting of two apoA-I molecules wrapped beltwise around a small patch of bilayer containing 160 lipid molecules. The C-terminal domain of each monomer is ringlike, a curved, planar amphipathic α helix with an average of 3.67 residues per turn, and with the hydrophobic surface curved toward the lipids. We have explored all possible geometries for forming the dimer of stacked rings, subject to the hypothesis that the optimal geometry will maximize intermolecular salt bridge interactions. The resulting model is an antiparallel arrangement with an alignment matching that of the (nonplanar) crystal structure of lipid-free apoA-I.
A Design Methodology for MOS Current-Mode Logic Frequency Dividers

In this work, a methodology for the design of MOS current-mode logic frequency dividers is presented. A mix of hand calculations and circuit simulations is used to relate the power consumption and the frequency of operation. Each latch in the dividers is sized separately in order to minimize the overall power consumption. Furthermore, the effect on the power consumption of circuit parameters such as output swing and voltage gain of the input differential pair is analyzed in detail. The methodology has been applied to dividers by two and dividers by three with 50% output duty cycle
Inhibition and aging: similarities between younger and older adults as revealed by the processing of unattended auditory information.

The ability to selectively attend to an auditory stimulus appears to decline with age and may result from losses in the ability to inhibit the processing of irrelevant stimuli (i.e., the inhibitory deficit hypothesis; L. Hasher & R. T. Zacks, 1988). It is also possible that declines in the ability to selectively attend are a result of age-related hearing losses. Three experiments examined whether older and younger adults differed in their ability to inhibit the processing of distracting stimuli when the listening situation was adjusted to correct for individual differences in hearing. In all 3 experiments, younger and older adults were equally affected by irrelevant stimuli, unattended stimuli, or both. The implications for auditory attention research and for possible differences between auditory and visual processing are discussed.
STABILITY OF CYCLIC THRESHOLD AND THRESHOLD-LIKE AUTOREGRESSIVE TIME SERIES MODELS

We investigate the stability, in terms of V -uniform ergodicity or tran- sience, of cyclic threshold autoregressive time series models. These models cycle through one of a number of collections of subregions of the state space when the process is large. Our results can be applied in cases where the model has multiple cycles and/or ane thresholds. The bounds on the parameter space are sharper than those in previous results, and are easily veried. We extend these results to autoregressive nonlinear time series that can be approximated well by a threshold model (threshold-like).
FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis (*)

CD95 (Fas/APO-1) and tumor necrosis factor receptor-1 (TNFR-1) are related molecules that signal apoptosis. Recently, a number of novel binding proteins have been proposed to mediate the signaling of these death receptors. Here we report that an N-terminal truncation of one of these candidate signal transducers, FADD/MORT1, abrogates CD95-induced apoptosis, ceramide generation, and activation of the cell death protease Yama/CPP32. In addition, this dominant-negative derivative of FADD (FADD-DN) blocked TNF-induced apoptosis while not affecting NF-κB activation. FADD-DN bound both receptors, and in the case of CD95, it disrupted the assembly of a signaling complex. Taken together, our results functionally establish FADD as the apoptotic trigger of CD95 and TNFR-1.
Summary Dis 1 / TOG universal microtubule adaptors-one MAP for all ?

Microtubules represent one of three cytoskeletal systems found in all eukaryotes and play a wide variety of roles in cell division, cell architecture, cell polarity and intracellular transport. One of the most remarkable features of the microtubule is its dynamic behaviour. Microtubule dynamics and organisation are regulated spatially and temporally in the cell cycle and during development, and an understanding of the underlying mechanisms is central to cell and molecular biology. In addition to intrinsic instability, a class of proteins collectively called microtubule-associated proteins (MAPs), which includes microtubule motors, plays a key role in the regulation of microtubules in vivo (Mandelkow and Mandelkow, 1995). ‘Conventional’ MAPs were biochemically identified from mammalian brains through co-purification with microtubules some years ago. These are highly expressed mainly in neuronal cells and stabilise microtubules that form the backbone of highly polarised cells. Given the ubiquitous existence and highly dynamic nature of the microtubule in vivo, it is reasonable to assume that MAPs other than these neuronal forms might play an important role in dividing cells. Recently, a highly conserved family of MAPs, the Dis1/TOG family, was discovered in various organisms, including yeasts, animals and plants. These MAPs associate with various microtubule structures in a dynamic way and appear to be involved in a range of different aspects of microtubule function for example, kinetochore function, spindle formation and cell morphogenesis. Although our knowledge of this new family of MAPs is still relatively patchy, some unified images have already started to emerge. Here, we review in vivo roles of these MAPs in different microtubule functions across different organisms in relation to their localisation and biochemical properties. We discuss how and why these highly conserved MAPs are used so widely in different aspects of microtubule function.
Supply chain analysis of e-tailing versus retailing operation – a case study

The swift growth of e-commerce or e-tailing as a consumer retail channel has made it a serious competitor to traditional retail channels and is changing consumers’ purchasing behaviour. The purpose of this case study, based on Target and Amazon.com, is to analyse the attributes of traditional retailing, e-tailing, and hybrid supply chain models to form conclusions about the feasibility of an idealised supply chain model for the future. An integrated and generalised modelling framework is used that incorporates Six Sigma – define, measure, analyse, improve, control methodology leveraging various tools, including process flow maps, cause and effect diagram, performance efficiency metrics, failure mode and effects analysis (FMEA), and Monte Carlo simulation. Based on this analysis and research, the conclusion is that the idealised supply chain of the future may evolve into a hybrid supply chain, which includes both e-tail and retail channels. The main recommendations from this study include assessing the risks of migrating to such a hybrid supply chain and to leverage the recommended actions provided in the hybrid FMEA. To facilitate more effective and mature processes, this study can guide researchers in exhaustive empirical evaluations of hybrid supply chains, gather experiences and lessons learned for practitioners.
Levonorgestrel Intrauterine System: A First-Line Medical Treatment for Heavy Menstrual Bleeding

Chronic heavy menstrual bleeding is a common gynecologic condition that causes significant health problems and negatively impacts a woman's quality of life. Surgical treatments should be reserved for women who have pelvic pathology and for those who fail medical therapy. The recent US FDA approval of the levonorgestrel-releasing intrauterine system as an indicated treatment for heavy menstrual bleeding in women who want to use intrauterine devices for birth control highlights the potential that this top tier contraceptive method offers as a first-line therapy for treatment of this problem in women of any reproductive age, without sacrificing their future fertility.
The Prostate 62 : 1 ^ 13 ( 2005 ) Substrates of the Prostate-Specific Serine Protease Prostase / KLK 4 Definedby Positional-Scanning Peptide Libraries

Masazumi Matsumura, Ami S. Bhatt, Dennis Andress, Nigel Clegg, Thomas K. Takayama, Charles S. Craik, and Peter S. Nelson* DivisionofHumanBiology, FredHutchinsonCancer ResearchCenter, Seattle,Washington Departmentof Pharmaceutical Chemistry, PrograminChemistryandChemical Biology, Universityof California, San Francisco,California DepartmentofMedicine,UniversityofWashington, Seattle,Washington DepartmentofUrology,UniversityofWashington, Seattle,Washington
The Sensorium: A Multimodal Neurofeedback Environment

The Sensorium is a neurofeedback environment that allows people to experience signals from their nonperceptible body processes visually and auditorily. Various (neuro-)physiological rhythms and frequencies are projected simultaneously as soundscapes and "lightscapes" into the environment. A wireless physiological amplifier device sends signals such as EEG and ECG to a computer for real-time processing using the modified brain-computer interface software "Thought Translation Device" (TTD). The TTD performs signal filtering, parametric orchestral sonification, and light control. In a pilot study, 20 participants have been exposed to their ongoing brain and heart signals while sitting inside the Sensorium, a small room equipped with a speaker and lighting system. Almost all of them reported an increase in contentment, relaxation, happiness, and inner harmony. They also reported a widening in their body consciousness. In future, therapeutic paradigms will be developed and the treatment effects on people with psychosomatic diseases will be evaluated.
Phase-Change Memory RESET Model Based on Detailed Cell Cooling Profile

A phase-change (PC) memory model that keeps track of the detailed cooling profile in the RESET process is described in this brief. By physically calculating the final crystal fraction resulting from the thermal dynamic of the PC material during the RESET process, the final resistance of the memory cell can be more accurately determined. The proposed model has been implemented in Verilog-A language and verified by experimental data.
The Power of Social Network Construction and Analysis for Knowledge Discovery in the Medical Referral Process

The social network model is powerful enough to provide for the analysis and study of a variety of application domains from daily life, including health care and health informatics. After the widespread appearance of automated tools capable of deriving and analyzing social networks, social network analysis (SNA) and mining in the health care domain has recently received considerable attention for its key role in understanding how various bodies within the health care system form communities and how they are socially connected with each other. This understanding helps enhance the organizational structures and process flows, among others. In this article, we show how SNA techniques can solve issues in the medical referral system in the Canadian health care system and the like, by analyzing the social network of general practitioners (GPs) and specialists (SPs). One of the main targets is to optimize the communication between GPs and SPs with hopes of decreasing the waiting time of patients to be seen by SPs. Various SNA and mining techniques are described and analyzed, backed by reporting some experimental results.
Numerical study on flow separation of a transonic cascade

The 3D compressible Navier-Stokes equations with BaldwinLomax turbulence model are solved to study the flow separation phenomenon in a NASA Transonic Flutter Cascade. The influence of the incidence angle and the inlet Mach number on the flow pattern in the cascade is numerically studied. When the incoming flow is subsonic, increasing the incidence angle generates a large separation region starting from the leading edge on the suction surface. Higher subsonic inlet Mach number results in a larger separation region. The separation region shrinks and moves downstream when the inlet Mach number is increased to supersonic due to the shock wave boundary layer interaction.
An application of database query translation into spreadsheets

Most common end users those who are not professional users finds difficult to specify queries against querying structured databases. The most commonly used applications for data management and analysis is the spreadsheet. Still the spreadsheet computation lacks enough analysis. Combining the concepts of spreadsheets and the database system can result into new formation which can be easily handled by the end users. The main topic of this article is to offer a fully automated method, a tool which constructs spreadsheet implementations of relational data transformations. This paper proposes an automated tool to store the data and translate it into spreadsheet system easily. The tool can be called as a Query-Converter which actually converts the database queries into formula based spreadsheets. It imposes techniques which overcomes the limitations of Database system by spreadsheets for effective Data Modeling Applications. Spreadsheets are also capable of implementing some graph traversing algorithms like BFS and DFS as additional tasks.
Simultaneous Measurement of RI and Temperature Based on a Composite Interferometer

A novel double-parameter sensor based on a composite interference structure has been designed and implemented in this letter. It can be regarded as a cascade of the conventional single-mode fiber (SMF)-multimode fiber-photonic crystal fiber-SMF structure, which forms a reflected Fabry-Perot interferometer and a transmitted Mach-Zehnder interferometer at the same time. In addition, a simultaneous measurement of temperature and refractive index has been achieved by monitoring the correlative moves of reflected spectrum and transmitted spectrum. The fact that these two spectra do not interfere with each other makes it easier to obtain a demodulation method that does not involve complex fast Fourier transform and matrix computation. The sensitivities of temperature and refractive index can reach up to 27.5 pm/°C and 108 nm/RIU, respectively.
Anthropology and Tourism: Past Contributions and Future Theoretical Challenges

As tourism continues to expand across the world, in terms of types and forms as well as tourist numbers, its global importance and impact correspondingly increase. Concurrently, the potential for the anthropological study of tourism grows. This paper discusses the relationship between anthropology and tourism in both historical and contemporary contexts. I investigate how and why these two areas of study are relevant to each other, highlighting some of the ways anthropologists and sociologists have been involved with tourism and the types of research undertaken. I argue that contemporary tourism poses new theoretical challenges for anthropological research.
Origins of Growth Factors: NGF and EGF

Growing up on the streets of Brooklyn, I remember being interested in how things worked: taking apart an old telephone and the gears of my new 4-speed bicycle was most enjoyable. As a biology major at Brooklyn College in 1945, I was fascinated by embryology. How does an egg turn into a chicken or a frog or a person? My only insight into the problem was the thought that it was necessary to understand the chemical reactions inside the egg and embryo and not simply observe biological structures. I, therefore, became a double major in chemistry and biology (also with the hope of earning a living as a laboratory technician). My first job after graduating was working nights as a bacteriologist in a milk processing plant. One of my professors at Brooklyn College wrote asking whether I was interested in going to graduate school. The college had been sending one student a year to the Biology Department at Oberlin to work as a laboratory assistant while studying for a master's degree. Because Oberlin offered to pay my tuition plus some $300 a semester for living expenses, I jumped at the chance. School and science were both interesting and fun. Upon graduating, I continued my education toward a Ph.D. working as an assistant in the Biochemistry Department of the University of Michigan under Howard B. Lewis. My research involved studying the Krebs urea cycle in the common earthworms that I collected from the university campus. I had been told at Oberlin that the yellow cells surrounding the gut in the worm corresponded to the mammalian liver. I decided to check whether the enzymatic reactions in worms were similar to those in mammals. They were (1). My first “real job” was in the Pediatrics Department at the University of Colorado studying creatine metabolism in premature infants under Harry Gordon. I think he hired me because he was impressed by my ability to stomach tube earthworms. After several years, I decided I needed to learn the then new technique of using radioisotopes in metabolic studies, and I obtained an American Cancer Society fellowship to work in the Radiology Department of Washington University under Martin Kamen where I combined this new knowledge with my interest in embryology. Although fertilized frog eggs and early embryos are impermeable to small molecules (amino acids, phosphates, etc.), sufficient amounts of C14O2 were metabolized by intact eggs and embryos to permit the identification of the radioactive compounds present at various stages of development (2). Upon completion of my fellowship, Dr. Kamen recommended me for a position in the Zoology Department of Washington University in the laboratory of Viktor Hamburger and Rita Levi-Montalcini. This move was critical in determining the direction of my research for the next 40-some odd years: the isolation, structure, and function of the first of the “growth factors,” nerve growth factor (NGF) and epidermal growth factor (EGF).
First report of the leaf-mining genus Antispila Hübner, [1825] from mainland China, with the description of a new species feeding on Cornus (Lepidoptera, Heliozelidae)

Abstract The genus Antispila Hübner, [1825] is newly recorded from mainland China. Antispila sinensis sp. n. , the first formally named Heliozelidae species in mainland China, is described. The host plant of the new species, Cornus walteri Wangerin (Cornaceae), is widespread through east Asia and is used as a shade tree in city parks in Jinan City, where the moth causes damage to foliage. Morphological and molecular analyses distinguish A. sinensis sp. n. from its close relatives. The adult, pupa, larva, host plant, leaf-mines, and the shield of the new species are illustrated, as are male and female genitalia, venation, and larval chaetotaxy. DNA barcodes of the new species are also provided.
The Bone Wars : Design and Development , Social Media and Community

The Bone Wars is an original educational video game about the historic 19th-century feud between rival paleontologists, Othniel C. Marsh and Edward D. Cope. This two-player game explores their race to claim dig sites and discover new species, but its only by publishing their results that the players earn the fame that delivers victory. Just as their historic characters did, a successful player will end the game with little money, few friends, many publications, and crates of unanalyzed fossils. The game was designed and developed in a student-centered, faculty-mentored studio experience by a team of ten undergraduates and one graduate student. The team followed established practices of game design and agile software development, making effective use of a dedicated lab environment. The incremental and iterative development process was publicly shared on the team’s blog and on Twitter, and we describe the impact that this had on the team and on the community of potential players.
Prolonged Blood Circulation of Methotrexate by Modulation of Liposomal Composition

Prolonged circulation by liposomal incorporation has been shown to enhance the therapeutic efficacy of drugs in many cases. The purpose of this study was to investigate whether the prolonged circulation of methotrexate (MTX) can be achieved by modulating the liposomal compositions. Various compositions of liposomes were prepared with 2:1 of phosphatidylcholine (PC) and cholesterol (CH) with or without distearoylphosphatidyl-ethanolamine-N-poly(ethyleneglycol) 2000 (DSPE-PEG). The MTX encapsulation efficiency depended on the type of PC used. It also appeared to increase by inclusion of DSPE-PEG. The size of liposomes decreased by the inclusion of DSPE-PEG. The inclusion of DSPE-PEG lowered the plasma-induced release of MTX from EggPC/CH and DPPC/CH liposomes, suggesting its enhancement effect on the liposomal stability. After intravenous injection to rats, the pharmaockinetics and biodistribution of MTX were significantly changed by liposomal incorporation and also by the composition of liposomes. The total body clearance of MTX incorporated in EggPC/CH, DPPC/CH, EggPC/CH/DSPE-PEG, and DPPC/CH/DSPE-PEG liposomes decreased 4.4-, 14.9-, 24.5-, and 53.1-fold, compared with that of free MTX. The ratio of MTX concentration in blood to liver and spleen after injection of DPPC/CH, EggPC/CH/DSPE-PEG, and DPPC/CH/DSPE-PEG liposomes was 5.4-, 8.5-, and 13.5-fold higher than that of EggPC/CH liposomes. Furthermore, the accumulation of MTX in the kidney, one of the organs in which MTX exhibits its toxicity, was significantly lowered by liposomal incorporation, especially by DSPE-PEG-containing liposomes. Taken together, DPPC/CH/DSPE-PEG liposomes most effectively prolonged the blood circulation, and reduced hepatosplenic and kidney uptake of MTX. DPPC/CH/DSPE-PEG liposomes may have potential as an efficient delivery system for MTX.