Miracle-dz/UniFAR-FTUs huggingface dataset:
On‐demand recent personal tweets summarization on mobile devices

Tweets summarization aims to find a group of representative tweets for a specific set of input tweets or a given topic. In recent times, there have been several research efforts toward devising a variety of techniques to summarize tweets in Twitter. However, these techniques are either not personal (that is, consider only tweets in the timeline of a specific user) or are too expensive to be realized on a mobile device. Given that 80% of active Twitter users access the site on mobile devices, in this article we present a lightweight, personal, on‐demand, topic modeling‐based tweets summarization engine called TOTEM, designed for such devices. Specifically, TOTEM first preprocesses recent tweets in a user's timeline and exploits Latent Dirichlet Allocation‐based topic modeling to assign each preprocessed tweet to a topic. Then it generates a ranked list of relevant tweets, a topic label, and a topic summary for each of the topics. Our experimental study with real‐world data sets demonstrates the superiority of TOTEM.
Degradation of 2,4-dichlorophenol by cathodic microarc plasma electrolysis: characteristics and mechanisms

ABSTRACT In this work, we used cathodic microarc plasma electrolysis (CMPE) to degrade 2,4-dichlorophenol (2,4-DCP) in simulated wastewater. By investigating and comparing the removal efficiencies and chemical oxygen demand (COD) during the degradation process, higher bath voltage and alkaline condition were considered as more suitable for the 2,4-DCP decomposition. Higher initial 2,4-DCP concentration was attributed to the increase in the utilisation of the energy input. The plasma characteristics during CMPE were studied by optical emission spectroscopy (OES). It was found that the 2,4-DCP directly participated in the plasma discharge process. Furthermore, by studying the evolution of intermediate products at different experimental parameters, it was found that the existence of Cl- played an important role in the opening of benzene ring, which activated the ortho-substitutions of hydroxyl, meanwhile accelerated the p-substitutions. The instantaneous high temperature and high pressure and the Cl- that were generated and driven by cathodic plasma made the decomposition of 2,4-DCP much quicker. GRAPHICAL ABSTRACT
Rural Population Health and Aging: Toward a Multilevel and Multidimensional Research Agenda for the 2020s.

The unique health and aging challenges of rural populations often go unnoticed. In fact, the rural United States is home to disproportionate shares of older and sicker people, there are large and growing rural-urban and within-rural mortality disparities, many rural communities are in population decline, and rural racial/ethnic diversity is increasing.Yet rural communities are not monolithic, and although some rural places are characterized by declining health, others have seen large improvements in population health. We draw on these realities to call for new research in five areas.First, research is needed to better describe health disparities between rural and urban areas and, because rural places are not monolithic, across rural America. Second, research is needed on how trends in rural population health and aging are affecting rural communities. Third, research is needed on the ways in which economic well-being and livelihood strategies interact with rural health and aging. Fourth, we need to better understand the health implications of the physical and social isolation characterizing many rural communities. Finally, we argue for new research on the implications of local natural environments and climate change for rural population health and aging. (Am J Public Health. Published online ahead of print July 16, 2020: e1-e4. doi:10.2105/AJPH.2020.305782).
Fator de cubicação para toretes de Eucalyptus grandis e sua variação com o tempo de exposição ao ambiente.

Sometimes the express wood volume in stere needs to be converted into cubic meter. This is possible estimating a cubication factor (Fc). With the objective of determining the Fc for Eucalyptus grandis and its variation in wood pieces of different lengths of 1 and 2,3m due to time of exposure to the environment, in the summer and in the winter, six stacks of woodpiles were made in the dimensions 3x2x1m and six piles in the dimensions 3x2x2, 3m, installed in the summer and in the winter. Medium Fcc’s obtained by the reason of volumes presented smaller variation in comparison to the ones obtained by angular counting. The statistical analysis indicated difference (α < 5%) in the variables of the main effect, that is: in the climatic station (F = 18.72), in the time of exhibition (F = 6.51) and in the length of the stacks (F = 35.18). The analysis of the correlation indicated that Fc was also influenced by the top cracks, by the humidity of the wood and by the atmospheric variability. The average values of Fcc’s indicated a stabilization after ninety days of the installation of the piles. The stacks of Eucalyptus grandis presented dimensional variation when exposed to the atmosphere, making the Fc to vary in the time of exhibition at environment.
Tolerance for specific negative affective states and coping-oriented cannabis use motives among college student cannabis users

Abstract Objective The current study examined the unique predictive ability of tolerance of specific negative affective states in relation to frequency of past-month cannabis use and coping-oriented cannabis use motives. Participants: 416 undergraduates who reported past 30 day cannabis use (65.1% female; Mage = 19.46, SD = 2.56). Methods: Participants completed self-report questionnaires for course credit. Results: After accounting for the effects of sex, negative affectivity, and tolerance of other specific negative affective states, lower levels of tolerance for sadness, but not any other negative affective states, significantly predicted more frequent cannabis use in the past 30 days (1.1% unique variance) and coping motives (1.1% unique variance). Conclusions: These findings suggest that cannabis users who have difficulty withstanding sad mood states use cannabis more frequently and are motivated to use cannabis to cope with this specific mood state and not necessarily negative affective states more broadly.
Is auscultation an issue when validating 24-h blood pressure monitoring devices?

The auscultatory BP estimation technique, relying on K1 and K5 Korotkoff sounds, is the current reference to validate automated devices in the sitting position. With a growing need for automated 24-h BP monitoring, we will have to perform device validation in positions other than sitting and to evaluate the possibility of bias related to posture change. There have been few data to assess whether auscultation is adequate for this purpose. The origins of Korotkoff sounds are not fully understood; they are known to be affected by changes in vascular tone, which depend on extrinsic and intrinsic factors [1]. A recent review of 62 studies reported systematic differences between auscultation and invasive measurements that did not fall within the requirements of current standards [2].
Fractional GPUs: Software-Based Compute and Memory Bandwidth Reservation for GPUs

GPUs are increasingly being used in real-time systems, such as autonomous vehicles, due to the vast performance benefits that they offer. As more and more applications use GPUs, more than one application may need to run on the same GPU in parallel. However, real-time systems also require predictable performance from each individual applications which GPUs do not fully support in a multi-tasking environment. Nvidia recently added a new feature in their latest GPU architecture that allows limited resource provisioning. This feature is provided in the form of a closed-source kernel module called the Multi-Process Service (MPS). However, MPS only provides the capability to partition the compute resources of GPU and does not provide any mechanism to avoid inter-application conflicts within the shared memory hierarchy. In our experiments, we find that compute resource partitioning alone is not sufficient for performance isolation. In the worst case, due to interference from co-running GPU tasks, read/write transactions can observe a slowdown of more than 10x. In this paper, we present Fractional GPUs (FGPUs), a software-only mechanism to partition both compute and memory resources of a GPU to allow parallel execution of GPU workloads with performance isolation. As many details of GPU memory hierarchy are not publicly available, we first reverse-engineer the information through various micro-benchmarks. We find that the GPU memory hierarchy is different from that of the CPU, making it well-suited for page coloring. Based on our findings, we were able to partition both the L2 cache and DRAM for multiple Nvidia GPUs. Furthermore, we show that a better strategy exists for partitioning compute resources than the one used by MPS. An FGPU combines both this strategy and memory coloring to provide superior isolation. We compare our FGPU implementation with Nvidia MPS. Compared to MPS, FGPU reduces the average variation in application runtime, in a multi-tenancy environment, from 135% to 9%. To allow multiple applications to use FGPUs seamlessly, we ported Caffe, a popular framework used for machine learning, to use our FGPU API.
The Smallest Isoform of Metridia longa Luciferase as a Fusion Partner for Hybrid Proteins

Bioluminescent proteins are widely used as reporter molecules in various in vitro and in vivo assays. The smallest isoform of Metridia luciferase (MLuc7) is a highly active, naturally secreted enzyme which, along with other luciferase isoforms, is responsible for the bright bioluminescence of marine copepod Metridia longa. In this study, we report the construction of two variants of a hybrid protein consisting of MLuc7 and 14D5a single-chain antibody to the surface glycoprotein E of tick-borne encephalitis virus as a model fusion partner. We demonstrate that, whereas fusion of a single-chain antibody to either N- or C-terminus of MLuc7 does not affect its bioluminescence properties, the binding site on the single-chain antibody influences its binding capacity. The affinity of 14D5a-MLuc7 hybrid protein (KD = 36.2 nM) where the C-terminus of the single-chain antibody was fused to the N-terminus of MLuc7, appeared to be 2.5-fold higher than that of the reverse, MLuc7-14D5a (KD = 87.6 nM). The detection limit of 14D5a-MLuc7 hybrid protein was estimated to be 45 pg of the recombinant glycoprotein E. Although the smallest isoform of M. longa luciferase was tested as a fusion partner only with a single-chain antibody, it is reasonable to suppose that MLuc7 can also be successfully used as a partner for genetic fusion with other proteins.
How important is obesity as a risk factor for respiratory failure, intensive care admission and death in hospitalised COVID-19 patients? Results from a single Italian centre

Abstract Objective Specific comorbidities and old age create a greater vulnerability to severe Coronavirus Disease 19 (COVID-19). While obesity seems to aggravate the course of disease, the actual impact of the BMI and the cutoff which increases illness severity are still under investigation. The aim of the study was to analyze whether the BMI represented a risk factor for respiratory failure, admission to the intensive care unit (ICU) and death. Research design and methods A retrospective cohort study of 482 consecutive COVID-19 patients hospitalised between March 1 and April 20, 2020. Logistic regression analysis and Cox proportion Hazard models including demographic characteristics and comorbidities were carried out to predict the endpoints within 30 days from the onset of symptoms. Results Of 482 patients, 104 (21.6%) had a BMI ≥ 30 kg/m2. At logistic regression analysis, a BMI between 30 and 34.9 kg/m2 significantly increased the risk of respiratory failure (OR: 2.32; 95% CI: 1.31–4.09, P = 0.004) and admission to the ICU (OR: 4.96; 95% CI: 2.53–9.74, P < 0.001). A significantly higher risk of death was observed in patients with a BMI ≥ 35 kg/m2 (OR: 12.1; 95% CI: 3.25–45.1, P < 0.001). Conclusions Obesity is a strong, independent risk factor for respiratory failure, admission to the ICU and death among COVID-19 patients. A BMI ≥ 30 kg/m2 identifies a population of patients at high risk for severe illness, whereas a BMI ≥ 35 kg/m2 dramatically increases the risk of death.
Inferring Evolutionary Process from Phylogenetic Tree Shape

Inferences about macroevolutionary processes have traditionally depended solely on the fossil record, but such inferences can be strengthened by also considering the shapes of the phylogenetic trees that link extant taxa. The realization that phylogenies reflect macroevolutionary processes has led to a growing literature of theoretical and comparative studies of tree shape. Two aspects of tree shape are particularly important: tree balance and the distribution of branch lenghts. We examine and evaluate recent developments in and connections between these two aspects, and suggest directions for future research. Studies of tree shape promise useful and powerful tests of macroevolutionary hypotheses. With appropriate further research, tree shape may help us detect mass extinctions and adaptive radiations, measure continuos variation in speciation and extinction rates, and associate changes in these rates with ecological or biogeographical causes. The usefulness of tree shape extends well beyond the study of macroevolution. We discuss applications to other areas of biology, including coevolution, phylogenetic inference, population biology, and developmental biology.
Robotic diaphragmatic plication for eventration: A retrospective analysis of efficacy, safety, and feasibility

Eventration of the diaphragm results in impaired respiratory mechanics, which leads to symptoms of dyspnea. Robotic diaphragmatic plication is a recently reported technique that has had good immediate outcomes. The aim of this study was to describe our transthoracic and transabdominal plication techniques and to analyze the safety, efficacy, and feasibility of robotic diaphragmatic plication in an Indian setting.
Genome-Wide Identification of the CrRLK1L Subfamily and Comparative Analysis of Its Role in the Legume-Rhizobia Symbiosis

The plant receptor-like-kinase subfamily CrRLK1L has been widely studied, and CrRLK1Ls have been described as crucial regulators in many processes in Arabidopsis thaliana (L.), Heynh. Little is known, however, about the functions of these proteins in other plant species, including potential roles in symbiotic nodulation. We performed a phylogenetic analysis of CrRLK1L subfamily receptors of 57 different plant species and identified 1050 CrRLK1L proteins, clustered into 11 clades. This analysis revealed that the CrRLK1L subfamily probably arose in plants during the transition from chlorophytes to embryophytes and has undergone several duplication events during its evolution. Among the CrRLK1Ls of legumes and A. thaliana, protein structure, gene structure, and expression patterns were highly conserved. Some legume CrRLK1L genes were active in nodules. A detailed analysis of eight nodule-expressed genes in Phaseolus vulgaris L. showed that these genes were differentially expressed in roots at different stages of the symbiotic process. These data suggest that CrRLK1Ls are both conserved and underwent diversification in a wide group of plants, and shed light on the roles of these genes in legume–rhizobia symbiosis.
UPLC-MS/MS Phytochemical Analysis of Two Croatian Cistus Species and Their Biological Activity

Aqueous extracts of two Cistus species wild growing in Croatia—Cistus creticus (CC) and Cistus salviifolius (CS)—have been assessed with UPLC-MS/MS, showing 43 different phytochemicals, with flavonol glycosides: myricetin-3-hexoside and myricetin-rhamnoside, predominate ones in CC and myricetin-3-hexoside in CS. Antioxidant potential tested with the FRAP method showed no difference between CS and CC aqueous extracts, while higher phenolic content of CC comparing to CS, determined with a Folin–Cicolateu reagent correlated to its higher antioxidant capacity observed by the DPPH method. Both extracts were assessed for antimicrobial activity, using disc-diffusion and broth microdilution assays, targeting the opportunistic pathogens, associated with food poisoning, urinary, respiratory tract, blood stream and wound infections in humans. Antimicrobial assays revealed that fungi were in general more sensitive to both Cistus aqueous extracts, comparing to the bacteria where two extracts showed very similar activity. The most potent activity was observed against A. baumannii for both extracts. The extracts were tested on human lung cancer (A549) cell line using the MTT assay, showing very similar antiproliferative activity. After 72 h treatment with CC and CS aqueous extracts in concentration of 0.5 g/L, the viability of the cells were 37% and 50% respectively, compared to non-treated cells.
Reclaiming ʻĀina Health in Waimānalo

Kānaka Maoli (Native Hawaiian) worldviews of health emphasize pono (righteousness) and lōkahi (balance), which extends to include relationships with other people, akua (spiritual realm), and ʻāina (land). The purpose of this qualitative study was to explore the role of ʻāina and ʻāina connection in health and resilience based on the perspectives of 12 Kānaka Maoli adults from the Waimānalo community. Three major themes were identified: ʻĀina is everything, ʻāina is health, and community healing through community-led initiatives. A better understanding of ʻāina connection is important to improve our knowledge of Hawaiian health. A connection to ʻāina may specifically address health concerns resulting from historical trauma and environmental changes.
II. Yeast sequencing reports. A putative P‐type Cu2+‐transporting ATPase gene on chromosome II of Saccharomyces cerevisiae

We have sequenced a gene on the right arm near the telomere of chromosome II of Saccharomyces cerevisiae which codes for a putative P‐type cation‐transporting ATPase (PCA1). The gene codes for a 1216 amino acids protein. The PCA1 gene expresses a 3·5 kb message in both haploid and diploid cells when grown in glucose‐based rich medium YPD. The gene product is most similar at the C‐terminal region to a human copper‐transporting ATPase and Enterococcus hirae copper‐transporting ATPases and also an N‐terminal dithiol region that was proposed to be a ‘metal‐binding motif’. Cells lacking PCA1 display no obvious phenotype when tested under standard conditions; whereas they cease growth much earlier than the isogenic wild‐type cells in a minimal medium with high copper concentration. Overexpression of PCA1 under GAL1/10 promoter in yeast cells causes poor growth. We also show that yeast strains carrying PCA1 in multiple copies grow slower than isogenic wild‐type strains in a minimal synthetic medium containing 0·3 mM‐CuSO4. The sequence has been deposited in the EMBL data library under Accession Number Z29332.
The undiagnosed disease burden associated with alpha-1 antitrypsin deficiency genotypes

Alpha-1 antitrypsin deficiency (AATD), mainly due to the PI*ZZ genotype in SERPINA1, is one of the most common inherited diseases. Since it is associated with a high disease burden and partially prevented by smoking cessation, identification of PI*ZZ individuals through genotyping could improve health outcomes. We examined the frequency of the PI*ZZ genotype in individuals with and without diagnosed AATD from UK Biobank, and assessed the associations of the genotypes with clinical outcomes and mortality. A phenome-wide association study (PheWAS) was conducted to reveal disease associations with genotypes. A polygenic risk score (PRS) for forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio was used to evaluate variable penetrance of PI*ZZ. Among 458 164 European-ancestry participants in UK Biobank, 140 had the PI*ZZ genotype and only nine (6.4%, 95% CI 3.4–11.7%) of them were diagnosed with AATD. Those with PI*ZZ had a substantially higher odds of COPD (OR 8.8, 95% CI 5.8–13.3), asthma (OR 2.0, 95% CI 1.4–3.0), bronchiectasis (OR 7.3, 95%CI 3.2–16.8), pneumonia (OR 2.7, 95% CI 1.5–4.9) and cirrhosis (OR 7.8, 95% CI 2.5–24.6) diagnoses and a higher hazard of mortality (2.4, 95% CI 1.2–4.6), compared to PI*MM (wildtype) (n=398 424). These associations were stronger among smokers. PheWAS demonstrated associations with increased odds of empyema, pneumothorax, cachexia, polycythaemia, aneurysm and pancreatitis. Polygenic risk score and PI*ZZ were independently associated with FEV1/FVC <0.7 (OR 1.4 per 1-sd change, 95% CI 1.4–1.5 and OR 4.5, 95% CI 3.0–6.9, respectively). The important underdiagnosis of AATD, whose outcomes are partially preventable through smoking cession, could be improved through genotype-guided diagnosis. Only 6.4% of those with genotype-defined alpha-1 antitrypsin deficiency had been diagnosed with this serious disease in UK Biobank. Genotype-guided diagnosis could help to identify the thousands of people in the UK with this partially preventable disease. https://bit.ly/3dMu5Ng
Internet-Delivered Cognitive Behavioral Therapy for Problematic Alcohol Use in a Workplace Setting: Protocol for Quantitative and Qualitative Evaluation of Feasibility and Outcomes

Background Internet-based cognitive behavioral therapy (ICBT) for mental health issues has been successfully implemented in routine health care settings, and research indicates that ICBT can also be applied to decrease problematic alcohol use in workplace settings. However, studies investigating the feasibility of implementing ICBT in a workplace setting have been lacking. Objective The current study aims to investigate the feasibility of delivering ICBT for problematic alcohol use within an employee assistance program (EAP). Methods The study has a quantitative naturalistic design, quantitively comparing ICBT and face-to-face treatment, and allowing for qualitative interviews with employees and employers. Recruitment of participants follows a five-session in-person psychological assessment at an EAP regarding an employee’s presumed problematic alcohol consumption. All assessed employees referred to ICBT or face-to-face treatment will be offered participation in the study. Interviews will be held with employees and their employer representatives following ICBT to elucidate both stakeholders’ experience and perception of ICBT and its context. Outcome comparisons between ICBT and face-to-face treatment will be assessed quantitatively using a Reliable Change Index and analysis of variance. Thematic analysis and Grounded Theory will be used to analyze the interview material. Results The study is set to begin in April 2020 and to end in September 2021. The aim is to recruit up to 150 participants to the quantitative part of the study and 45 participants (15 employees and 30 employer representatives) to the qualitative part of the study. Conclusions The current study will provide knowledge that is lacking and urgently needed on how to implement ICBT for problematic alcohol use in a workplace setting. International Registered Report Identifier (IRRID) PRR1-10.2196/18693