Miracle-dz/UniFAR-FTUs huggingface dataset:
Intrarenal Arterial Transplantation of Dexmedetomidine Preconditioning Adipose Stem-Cell-Derived Microvesicles Confers Further Therapeutic Potential to Attenuate Renal Ischemia/Reperfusion Injury through miR-122-5p/Erythropoietin/Apoptosis Axis

Intravenous adipose mesenchymal stem cells (ADSCs) attenuate renal ischemia/reperfusion (IR) injury but with major drawbacks, including the lack of a specific homing effect after systemic infusion, cell trapping in the lung, and early cell death in the damaged microenvironment. We examined whether intrarenal arterial transplantation of dexmedetomidine (DEX) preconditioning ADSC-derived microvesicles (DEX-MVs) could promote further therapeutic potential to reduce renal IR injury. We evaluated the effect of DEX-MVs on NRK-52E cells migration, hypoxia/reoxygenation (H/R)-induced cell death, and reactive oxygen species (ROS) amount and renal IR model in rats. IR was established by bilateral 45 min ischemia followed by 4 h reperfusion. Intrarenal MVs or DEX-MVs were administered prior to ischemia. Renal oxidative stress, hemodynamics and function, western blot, immunohistochemistry, and tubular injury scores were determined. The miR-122-5p expression in kidneys was analyzed using microarrays and quantitative RT-PCR and its action target was predicted by TargetScan. DEX-MVs were more efficient than MVs to increase migration capability and to further decrease H/R-induced cell death and ROS level in NRK-52E cells. Consistently, DEX-MVs were better than MV in increasing CD44 expression, improving IR-depressed renal hemodynamics and renal erythropoietin expression, inhibiting IR-enhanced renal ROS level, tubular injury score, miR-122-5p expression, pNF-κB expression, Bax/caspase 3/poly(ADP-ribose) polymerase (PARP)-mediated apoptosis, blood urea nitrogen, and creatinine levels. The use of NRK-52E cells confirmed that miR-122-5p mimic via inhibiting erythropoietin expression exacerbated Bax-mediated apoptosis, whereas miR-122-5p inhibitor via upregulating erythropoietin and Bcl-2 expression reduced apoptosis. In summary, intrarenal arterial DEX-MV conferred further therapeutic potential to reduce renal IR injury through the miR-122-5p/erythropoietin/apoptosis axis.
Survey of Land Measurement Practices Department of PTSP FT UNM on Various Civil Engineering Works

This research was conducted to obtain data related to the relevance of the practice material of Land Measurement, Civil Engineering and Planning Education Department, Faculty of Engineering, Makassar State University (UNM) in various civil engineering jobs. The method in this research is quantitative research with descriptive analysis design. The samples taken are 25 alumnus and students who have experience in the field of land measurement. Technical analysis of data using coding techniques (coding), scoring (scoring) and percentages. In collecting research data, using a questionnaire method or a questionnaire containing statements related to jobs taught to students of the Department of Civil Engineering and Planning Education. The results showed that the average value (mean) of the relevance of the practice material of soil measurement of the Civil Engineering and Planning Education Department in various civil engineering jobs is on an interval scale of 3.28 - 4.03 or with the highly relevant criteria
ROS Suppression by Egg White Hydrolysate in DOCA-Salt Rats—An Alternative Tool against Vascular Dysfunction in Severe Hypertension

This study aimed to evaluate the potential for lowering blood pressure and beneficial effects on mesenteric resistance arteries (MRA) and conductance vessels (aorta) produced by dietary supplementation of an egg white hydrolysate (EWH) in rats with severe hypertension induced by deoxycorticosterone plus salt treatment (DOCA-salt), as well as the underlying mechanisms involved. The DOCA-salt model presented higher blood pressure, which was significantly reduced by EWH. The impaired acetylcholine-induced relaxation and eNOS expression observed in MRA and aorta from DOCA-salt rats was ameliorated by EWH. This effect on vessels (MRA and aorta) was related to the antioxidant effect of EWH, since hydrolysate intake prevented the NF-κB/TNFα inflammatory pathway and NADPH oxidase-induced reactive oxygen species (ROS) generation, as well as the mitochondrial source of ROS in MRA. At the plasma level, EWH blocked the higher ROS and MDA generation by DOCA-salt treatment, without altering the antioxidant marker. In conclusion, EWH demonstrated an antihypertensive effect in a model of severe hypertension. This effect could be related to its endothelium-dependent vasodilator properties mediated by an ameliorated vessel’s redox imbalance and inflammatory state.
Clinical Characteristics and Prognostic Factors in Primary Breast Diffuse Large B-Cell Lymphoma

Background Primary breast diffuse large B-cell lymphoma (PB-DLBCL) is a rare subtype of non-Hodgkin lymphoma (NHL) with limited data on the clinical features and prognostic factors. Patients and Methods A consecutive cohort of patients with PB-DLBCL was retrospectively analyzed in our hospital from February 1997 through July 2018. The primary endpoint is overall survival (OS) contributing to any cause. Results A total of 76 patients were diagnosed with PB-DLBCL. The median age at diagnosis was 51 years (range: 25–80 years), with female prevalence (98.7%). Forty (52.6%) patients had right-sided breast involvement but no bilateral breast involvement at diagnosis. Overall, disease stages IE and IIE were seen in 55 (72.4%) and 21 (27.6%) patients, respectively. According to the stage-modified International Prognostic Index (IPI), 37 (48.7%) patients were classified in the very good risk group (IPI 0). Of the 72 patients available, the non-germinal center B-cell (non-GCB) subtype of DLBCL was observed in 66 (91.6%) patients. All patients received anthracycline-based chemotherapy, 56 (73.7%) with rituximab, 31 (40.8%) also with additional radiation therapy, and 14 (18.4%) patients received a prophylactic intrathecal injection. Seven (9.2%) patients had refractory disease. With a median follow-up of 6.8 years (range 0.4–25.0 years), 10 (13.2%) patients had a relapse in the central nervous system (CNS) site. The 5-year and 10-year OS of all the patients was 97.2% (95% CI: 99.3–89.5) and 84.8% (95% CI: 70.0–93.5), respectively. The median OS was not reached. The median progression-free survival (PFS) was 10.3 years for patients with PB-DLBCL. The 5-year PFS of all the patients was 76.3% (95% CI: 64.6–84.6). Univariate analysis revealed several prognostic factors, including stage-modified IPI, breast surgery, refractory disease, and CNS relapse. Multivariate analyses produced two independent prognostic factors for patients with PB-DLBCL, including stage-modified IPI score (2–3 versus 0) (hazard ratio: 19.114, 95% CI 1.841 to 198.451, p=0.013) and CNS relapse (hazard ratio: 5.522, 95% CI 1.059 to 28.788, p=0.043). Conclusion In our cohort, PB-DLBCL clinical features are similar to prior literature reports. Stage-modified IPI score and CNS relapse were associated with overall survival.
Formulation of Food-Grade Grease Using Paraffin Oil, Fumed Silica, and Chitosan

Three formulations intended for NSF H1 food-grade grease were prepared in this study comprising paraffin oil as a base oil and fumed silica as a thickener. No additive was added in formulation 1 (F1) and formulation 2 (F2), whereas chitosan was added in formulation 3 (F3) as an additive. A commercial food-grade grease (FGG) was used for comparison purposes. The formulated greases and the commercial FGG were characterised for thermal stability via thermogravimetric analysis (TGA) and derivative thermogravimetric analysis (DTG). Fourier-transform infrared (FTIR) spectroscopy, dropping point, oil separation, and consistency tests were also carried out to evaluate the properties of the greases. The FTIR spectra were obtained for the fresh and aged greases for grease characterisation. The results showed that the grease made with chitosan as an additive demonstrated higher oil separation, better consistency, and was less affected by ageing, as indicated by the change of grease colour after the oil separation test. F1, F2, F3, and the commercial FGG recorded dropping points higher than 350 °C, indicating no dropping point properties for the tested greases. The grease formulated with chitosan (F3) achieved the highest oil separation with 1.21%, while the commercial FGG recorded the lowest oil separation with 0.66%, followed by F1 and F3 with the oil separation of 0.99% and 0.98%, respectively. For the consistency test, the NLGI number for each formulation varied but the commercial FGG showed the lowest NLGI number of 2, whereas F3 showed the NLGI number in the range of 2–3, and F1 showed the NLGI number of 3. The aged grease of F3 had unchanged consistency after the oil separation test. Based on the results, the formulated greases have acceptable properties in comparison to the commercial FGG, and the addition of chitosan contributes positively to the grease characteristics.
Agronomic and Proteomic Assessment of Salt Stress Responses in Pennisetum glaucum (Pearl Millet) Genotypes

Salinity is one of the environmental stresses that alter protein expression. To evaluate that, two ICRISAT Pennisetum glaucum (pearl millet) genotypes (IP 19586 and IP 22269) were subjected to 0.3 dSm-1 and 10 dSm-1 salinities. The agronomic parameters and ion content were assessed to find the tolerance level of the genotype to salinity. Differential expression of proteins on salt stress in both genotypes were analyzed by 2-dimensional gel electrophoresis. MALDI–MS/MS-TOF-TOF analysis helped in ascertain the amino acid sequences and the MASCOT search suggested the biological process of the predicted proteins. IP 22269 exclude the accumulation of toxic level of sodium in leaf. Based on physiological responses, IP 22269 was proposed to be salt-sensitive, and IP 19586 salt-tolerant genotypes. 67 proteins were responsive either less or more abundant to salinity. As per findings, the proteins responsive to salt stress are granule-bound starch synthase 1, alpha-amylase, Meiotic recombination protein SPO11, flavonoid 3'- monooxygenase, ethylene receptor 4, protein transcription initiation factor Y 11g, and auxin-responsive protein IAA16. Further, based on the STRING analysis these proteins form a protein-protein interaction network with 171 proteins. This research elucidates few salt stress tolerance traits and network between the salt stress-responsive mechanisms in pearl millet.
WGS-Based Lineage and Antimicrobial Resistance Pattern of Salmonella Typhimurium Isolated during 2000–2017 in Peru

Salmonella Typhimurium is associated with foodborne diseases worldwide, including in Peru, and its emerging antibiotic resistance (AMR) is now a global public health problem. Therefore, country-specific monitoring of the AMR emergence is vital to control this pathogen, and in these aspects, whole genome sequence (WGS)—based approaches are better than gene-based analyses. Here, we performed the antimicrobial susceptibility test for ten widely used antibiotics and WGS-based various analyses of 90 S. Typhimurium isolates (human, animal, and environment) from 14 cities of Peru isolated from 2000 to 2017 to understand the lineage and antimicrobial resistance pattern of this pathogen in Peru. Our results suggest that the Peruvian isolates are of Typhimurium serovar and predominantly belong to sequence type ST19. Genomic diversity analyses indicate an open pan-genome, and at least ten lineages are circulating in Peru. A total of 48.8% and 31.0% of isolates are phenotypically and genotypically resistant to at least one antibiotic, while 12.0% are multi-drug resistant (MDR). Genotype–phenotype correlations for ten tested drugs show >80% accuracy, and >90% specificity. Sensitivity above 90% was only achieved for ciprofloxacin and ceftazidime. Two lineages exhibit the majority of the MDR isolates. A total of 63 different AMR genes are detected, of which 30 are found in 17 different plasmids. Transmissible plasmids such as lncI-gamma/k, IncI1-I(Alpha), Col(pHAD28), IncFIB, IncHI2, and lncI2 that carry AMR genes associated with third-generation antibiotics are also identified. Finally, three new non-synonymous single nucleotide variations (SNVs) for nalidixic acid and eight new SNVs for nitrofurantoin resistance are predicted using genome-wide association studies, comparative genomics, and functional annotation. Our analysis provides for the first time the WGS-based details of the circulating S. Typhimurium lineages and their antimicrobial resistance pattern in Peru.
Economic and Social Determinants of Democracy: An Empirical Evidence from Pakistan

Purpose: The purpose of this paper is to understand the dynamics of democracy through empirical analysis of socio-economic determinants of democracy Design/Methodology/Approach: This is an empirical study based on secondary data from 1980- 2018. This research employs the Auto-Regressive and Distributive Lag (ARDL) econometric technique to find short-run and long relationships between democracy and its influencing factors. Findings: This paper’s findings unearth that education expenditures and economic growth are positively associated with democracy and are statistically significant in the long run. Furthermore, government expenditure, trade openness, corruption, and law & order are negatively associated with democracy and statistically significant in the long run. Implications/Originality/Value This research suggests that it is importantly needed for the democratic government to rise the education expenditure and take an initiative for the better education of the voters, and make them able to understand their manifestos and the effects of their policies on the betterment of society. From top to bottom corruption and uncertain law & order situation in Pakistan would reduce trust in democracy and increases the level of frustration among citizens. The responsibility of improving the law & order situation and the eradication of corruption comes to the current Democratic government through strengthening the institutions and effective implementations.
Measuring Noise Temperatures of Phased-Array Antennas for Astronomy at CSIRO

Abstract We describe the development of a noise-temperature testing capability for phased-array antennas operating in receive mode from 0.7 GHz to 1.8 GHz. Sampled voltages from each array port were recorded digitally as the zenith-pointing array under test was presented with three scenes: (1) a large microwave absorber at ambient temperature, (2) the unobstructed radio sky, and (3) broadband noise transmitted from a reference antenna centred over and pointed at the array under test. The recorded voltages were processed in software to calculate the beam equivalent noise temperature for a maximum signal-to-noise ratio beam steered at the zenith. We introduced the reference-antenna measurement to make noise measurements with reproducible, well-defined beams directed at the zenith and thereby at the centre of the absorber target. We applied a detailed model of cosmic and atmospheric contributions to the radio sky emission that we used as a noise-temperature reference. We also present a comprehensive analysis of measurement uncertainty including random and systematic effects. The key systematic effect was due to uncertainty in the beamformed antenna pattern and how efficiently it illuminates the absorber load. We achieved a combined uncertainty as low as 4 K for a 40 K measurement of beam equivalent noise temperature. The measurement and analysis techniques described in this paper were pursued to support noise-performance verification of prototype phased-array feeds for the Australian Square Kilometre Array Pathfinder telescope.
New emission nebulae in the POSS field $18^\text h48^\text m+0^\circ$

By comparing red and infrared POSS prints of the field 18 h 48 m +0° we have identified four hitherto unknown emission nebulae. Three of these turn out to be compact planetary nebulae, two of which are probably type I PNe. None of these three nebulae has an IRAS counterpart, which indicates that they have small, if any, infrared excesses. The emission-line ratios in the spectrum of the remaining nebula, HHG 33.3+0.2, indicate that the gas is excited by shock. This, combined with its structure, indicates that HHG 33.3+0.2 is a Herbig-Haro object. This nebula is located near the well-studied reflection nebula GGD 30 and is probably related to a molecular cloud at 1.7 kpc
Global well-posedness and scattering for nonlinear Schr{\"o}dinger equations with algebraic nonlinearity when $d = 2, 3$, $u_{0}$ radial

In this paper we discuss global well - posedness and scattering for some initial value problems that are $L^{2}$ supercritical and $\dot{H}^{1}$ subcritical, with radial data. We prove global well - posedness and scattering for radial data in $H^{s}$, $s > s_{c}$, where the problem is $\dot{H}^{s_{c}}$ - critical. We make use of the long time Strichartz estimates of \cite{D2} to do this.
Development and Validation of an ICP-MS Method for the Detection of Platinum in the Lebanese Aquatic Environment

Lebanon is a Middle Eastern country located on the eastern Mediterranean coast. Compared to other countries in the MENA (Middle East North Africa) region, Lebanon is considered the richest in water resources. However, due to inadequate water management, Lebanese water resources are under stress. Water pollution is one of the main problems causing major concerns. The contamination of Lebanese surface water originates predominantly from the discharge of untreated municipal and industrial wastewater. With only a few studies investigating the level of water contamination in Lebanon, this research is the first to report the level of platinum in numerous rivers, three wastewater treatment plants, and two untreated sewage outfalls in coastal areas across Lebanon. To determine the platinum levels, an Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) method was developed and validated in compliance with the ICH guidelines. The method demonstrated acceptable sensitivity with LOQ and LOD equal to 2.35 and 0.56 ng L−1, respectively. The level of total platinum in the Lebanese water samples ranged between 22.44–53.32 ng L−1. These concentrations were all above the baseline concentration of platinum in tap water indicated by WHO and aligned with previous studies in other countries. Although the baseline concentration of platinum in Lebanese water resources is unknown and the source of the total platinum detected in this study could not be identified, these preliminary findings could serve as a foundation for future research.
Does the Stock Market Affect the Real Economy? An Empirical Analysis Based on China’s Stock Market Liquidity

This article investigates the causal effect between the stock market and the real economy. Based on the data of China’s A-share market from 1998 to 2017, this article uses the fixed-effect model and other methods to find the causal effect from the perspective of the impact of illiquidity at the individual stock level on enterprise investment decision-making. Empirical results show that stock illiquidity significantly decreases enterprise investment. Information asymmetry is one of the important channels between the stock market and the real economy. The financial constraints and agency conflicts caused by information asymmetry significantly affect the causal effect. Macroeconomic policies to alleviate market information asymmetry can effectively act on the real economy through the stock market. From the microperspective of studying the causal effect, this study controls the time effect and individual effect and further explores the influence mechanism between the stock market and the real economy. Research shows that macroeconomic policies can effectively affect the real economy through the stock market and provides decision-making references for future macropolicy formulation.
A Switchable Bandpass Filter for Broadband, Dual-Band and Tri-Band Operations

In this brief, a novel microstrip switchable bandpass filter (BPF) is presented. By switching RF p-i-n diodes on/off, the proposed topology could provide three different filtering states: broadband bandpass filter (BBPF), dual-band bandpass filter (DBPF) and tri-band bandpass filter (TBPF). For each state, the relationship between bandwidths and return losses are newly analyzed by proposed algorithm, then the design charts can be easily summarized. In order to improve selectivity and stopband rejection, two cascaded proposed topologies are also considered and discussed briefly. For demonstration, two switchable circuits are designed, fabricated and measured in the experiment. Simulated and measured results are matched very well.
Transcriptional Memory in Taraxacum mongolicum in Response to Long-Term Different Grazing Intensities

Grazing, as an important land use method in grassland, has a significant impact on the morphological and physiological traits of plants. However, little is known about how the molecular mechanism of plant responds to different grazing intensities. Here, we investigated the response of Taraxacum mongolicum to light grazing and heavy grazing intensities in comparison with a non-grazing control. Using de novo transcriptome assembly, T. mongolicum leaves were compared for the expression of the different genes under different grazing intensities in natural grassland. In total, 194,253 transcripts were de novo assembled and comprised in nine leaf tissues. Among them, 11,134 and 9058 genes were differentially expressed in light grazing and heavy grazing grassland separately, with 5867 genes that were identified as co-expression genes in two grazing treatments. The Nr, SwissProt, String, GO, KEGG, and COG analyses by BLASTx searches were performed to determine and further understand the biological functions of those differentially expressed genes (DEGs). Analysis of the expression patterns of 10 DEGs by quantitative real-time RT-PCR (qRT-PCR) confirmed the accuracy of the RNA-Seq results. Based on a comparative transcriptome analysis, the most significant transcriptomic changes that were observed under grazing intensity were related to plant hormone and signal transduction pathways, carbohydrate and secondary metabolism, and photosynthesis. In addition, heavy grazing resulted in a stronger transcriptomic response compared with light grazing through increasing the of the secondary metabolism- and photosynthesis-related genes. These changes in key pathways and related genes suggest that they may synergistically respond to grazing to increase the resilience and stress tolerance of T. mongolicum. Our findings provide important clues for improving grassland use and protection and understanding the molecular mechanisms of plant response to grazing.