Miracle-dz/UniFAR-FTUs huggingface dataset:
Ephrin-B1 Is a Novel Biomarker of Bladder Cancer Aggressiveness. Studies in Murine Models and in Human Samples

Bladder cancer (BC) is the ninth most common cancer worldwide, but molecular changes are still under study. During tumor progression, Epithelial cadherin (E-cadherin) expression is altered and β-catenin may be translocated to the nucleus, where it acts as co-transcription factor of tumor invasion associated genes. This investigation further characterizes E-cadherin and β-catenin associated changes in BC, by combining bioinformatics, an experimental murine cell model (MB49/MB49-I) and human BC samples. In in silico studies, a DisGeNET (gene-disease associations database) analysis identified CDH1 (E-cadherin gene) as one with highest score among 130 BC related-genes. COSMIC mutation analysis revealed CDH1 low mutations rates. Compared to MB49 control BC cells, MB49-I invasive cells showed decreased E-cadherin expression, E- to P-cadherin switch, higher β-catenin nuclear signal and lower cytoplasmic p-Ser33-β-catenin signal, higher Ephrin-B1 ligand and EphB2 receptor expression, higher Phospho-Stat3 and Urokinase-type Plasminogen Activator (UPA), and UPA receptor expression. MB49-I cells transfected with Ephrin-B1 siRNA showed lower migratory and invasive capacity than control cells (scramble siRNA). By immunohistochemistry, orthotopic MB49-I tumors had lower E-cadherin, increased nuclear β-catenin, lower pSer33-β-catenin cytoplasmic signal, and higher Ephrin-B1 expression than MB49 tumors. Similar changes were found in human BC tumors, and 83% of infiltrating tumors depicted a high Ephrin-B1 stain. An association between higher Ephrin-B1 expression and higher stage and tumor grade was found. No association was found between abnormal E-cadherin signal, Ephrin-B1 expression or clinical-pathological parameter. This study thoroughly analyzed E-cadherin and associated changes in BC, and reports Ephrin-B1 as a new marker of tumor aggressiveness.
Developmental Dimensions in Preterm Infants During the 1st Year of Life: The Influence of Severity of Prematurity and Maternal Generalized Anxiety

Background The literature has recognized premature birth as a risk factor for infant development and maternal anxiety. This study investigated the impact of the severity of birth weight, as well as of maternal anxiety at 3 months of infants’ corrected age, on infants’ outcomes during the 1st year postpartum. Moreover, it described the longitudinal trajectories of developmental outcomes, additionally exploring the impact of anxiety. Methods The study compared 147 mothers and their 147 newborns, differentiated in 25 Extremely Low Birth Weight (ELBW), 41 Very Low Birth Weight (VLBW), and 81 Full-Term (FT) infants. At 3, 9, and 12 months (corrected age in the case of preterm infants) the level of infants’ development was investigated according to the 5 quotients (Locomotor, Personal and Social, Hearing and Language, Eye-hand Co-ordination and Performance) of the Griffiths Mental Development Scales (GMDS-R). During the assessment of 3 months, mothers fulfilled Penn State Worry Questionnaire (PSWQ) to evaluate the presence of generalized anxiety. Results Among the 5 GMDS-R quotients, significant effect of severity of birth weight emerged only for Performance quotient: preterm infants (ELBW at 3 months; VLBW at 12 months) showed lower scores than FT ones. Moreover, this quotient decreased from 3 to 9 and to 12 months for VLBW and FT infants, while it was stable for ELBW ones. A significant interaction between severity of birth weight and maternal anxiety emerged for Hearing and Language and Locomotor quotients. In the first case, scores for ELBW infants, independently from maternal anxiety, decreased from 9 to 12 months. The same results emerged for VLBW infants, in the case of non-anxious mothers. Regarding Locomotor quotient, mean scores decreased from 3 to 9 and to 12 months for all groups in the case of non-anxious mothers. Conversely, when mothers were anxious, this decrease emerged only for VLBW infants. Lastly, ELBW, VLBW and FT showed difference in the growth and slope of the trajectories of different quotients. Conclusion The severity of birth weight for preterm infants, also in interaction with maternal anxiety, had significant and specific impact on different dimensions of infants’ development. Clinical implications of these results underline the need for individualized interventions.
Early Life Nutrition, Growth and Kidney Function in Children : the Generation R Study

textabstractIn this thesis, we examined early life determinants of growth and childhood kidney function.Adverse environmental exposures during early life may lead to fetal growth adaptations and influence on the development of chronic kidney disease in later life,as indicated by many lines of evidence. From both an etiological and a prevention perspective, it is important to identify specific factors, especially modifiable factors that lead to an impaired kidney development. The studies presented in this thesis were mainly focused on the identification of specific nutritional factors during fetal life and early childhood factors that are associated with growth patterns and childhood kidney function. The findings of this thesis suggest that early life nutrition is associated with fetal growth patterns and childhood kidney function. Further studies are needed to unravel these mechanisms and to identify whether these subclinical changes in kidney development have consequences for the development of chronic kidney disease in later life.
Gene Expression Profiles Identified Novel Urine Biomarkers for Diagnosis and Prognosis of High-Grade Bladder Urothelial Carcinoma

Bladder urothelial carcinoma (BC) has been identified as one of the most common malignant neoplasm worldwide. High-grade bladder urothelial carcinoma (HGBC) is aggressive with a high risk of recurrence, progression, metastasis, and poor prognosis. Therefore, HGBC clinical management is still a challenge. We performed the present study to seek new urine biomarkers for HGBC and investigate how they promote HGBC progression and thus affect the prognosis based on large-scale sequencing data. We identified the overlapped differentially expressed genes (DEGs) by combining GSE68020 and The Cancer Genome Atlas (TCGA) datasets. Subsequent receiver operating characteristic (ROC) curves, Kaplan-Meier (KM) curves, and Cox regression were conducted to test the diagnostic and prognostic role of the hub genes. Chi-square test and logistic regression were carried out to analyze the associations between clinicopathologic characteristics and the hub genes. Ultimately, we performed gene set enrichment analysis (GSEA), protein-protein interaction (PPI) networks, and Bayesian networks (BNs) to explore the underlying mechanisms by which ECM1, CRYAB, CGNL1, and GPX3 are involved in tumor progression. Immunohistochemistry based on The Human Protein Atlas and quantitative real-time polymerase chain reaction based on urine samples confirmed the downregulation and diagnostic values of the hub genes in HGBC. In conclusion, our study indicated that CRYAB, CGNL1, ECM1, and GPX3 are potential urine biomarkers of HGBC. These four novel urine biomarkers will have attractive applications to provide new diagnostic methods, prognostic predictors and treatment targets for HGBC, which could improve the prognosis of HGBC patients, if validated by further experiments and larger prospective clinical trials.
How to Form Good Habits? A Longitudinal Field Study on the Role of Self-Control in Habit Formation

When striving for long-term goals (e.g., healthy eating, saving money, reducing energy consumption, or maintaining interpersonal relationships), people often get in conflict with their short-term goals (e.g., enjoying tempting snacks, purchasing must-haves, getting warm, or watching YouTube video’s). Previous research suggests that people who are successful in controlling their behavior in line with their long-term goals rely on effortless strategies, such as good habits. In the present study, we aimed to track how self-control capacity affects the development of good habits in real life over a period of 90 days. Results indicated that habit formation increased substantially over the course of three months, especially for participants who consistently performed the desired behavior during this time. Contrary to our expectations, however, self-control capacity did not seem to affect the habit formation process. Directions for future research on self-control and other potential moderators in the formation of good habits are discussed.
Improving the energy economy of human running with powered and unpowered ankle exoskeleton assistance

Optimized assistance from powered ankle exoskeletons reduces energy cost during running, whereas spring-like assistance is ineffective. Exoskeletons that reduce energetic cost could make recreational running more enjoyable and improve running performance. Although there are many ways to assist runners, the best approaches remain unclear. In our study, we used a tethered ankle exoskeleton emulator to optimize both powered and spring-like exoskeleton characteristics while participants ran on a treadmill. We expected powered conditions to provide large improvements in energy economy and for spring-like patterns to provide smaller benefits achievable with simpler devices. We used human-in-the-loop optimization to attempt to identify the best exoskeleton characteristics for each device type and individual user, allowing for a well-controlled comparison. We found that optimized powered assistance improved energy economy by 24.7 ± 6.9% compared with zero torque and 14.6 ± 7.7% compared with running in normal shoes. Optimized powered torque patterns for individuals varied substantially, but all resulted in relatively high mechanical work input (0.36 ± 0.09 joule kilogram−1 per step) and late timing of peak torque (75.7 ± 5.0% stance). Unexpectedly, spring-like assistance was ineffective, improving energy economy by only 2.1 ± 2.4% compared with zero torque and increasing metabolic rate by 11.1 ± 2.8% compared with control shoes. The energy savings we observed imply that running velocity could be increased by as much as 10% with no added effort for the user and could influence the design of future products.
Primary Follicular Lymphoma of the Gastrointestinal Tract

Although the gastrointestinal tract represents the most common site of extranodal lymphoma, primary follicular lymphoma of the gastrointestinal tract is an uncommon and poorly defined disease. We report the clinical and pathologic features of 26 patients with primary gastrointestinal follicular lymphoma. Ten of 26 patients (38.5%) were stage IIE, and 16 patients (61.5%) were stage IE. Of the 26 patients, 13 were female and 13 were male. The age range was 26–81 years (median 54.5 years). Abdominal pain was the most common presenting symptom, seen in 12 of 24 patients (50%). Nodularity of the mucosal surface was the most common endoscopic finding, seen in 10 of 14 patients (71.4%). The majority of cases (22 of 26, 84.6%) involved small bowel, four involved colorectum alone, and two involved the ileocecal valve. Within the small bowel the duodenum was the most commonly involved site (10 cases). Transmural involvement by follicular lymphoma was identified in 11 of the 16 patients who underwent surgical resection; five showed involvement of mucosa and submucosa only. The most common histologic grade was grade 1. Thirteen of 26 cases were grade 1, ten grade 2, and three grade 3. Twenty-one of 26 cases showed a predominantly follicular growth pattern, four mixed follicular and diffuse, and one predominantly diffuse. All cases were positive for CD20 and BCL2 and negative for CD3, CD5, CD23, CD43, and cyclin D1. Twenty-four of 26 were positive for CD10. Four of four cases showed cytogenetic or molecular genetic evidence of t(14;18). Initial treatment modalities included surgery plus chemotherapy (nine cases), surgery alone (seven cases), chemotherapy alone (four cases), observation alone (four cases), and chemotherapy and abdominal radiation (one case). One case presented with rectal polyps and was treated with polypectomy. A complete response was observed in 15 of 22 cases that received treatment, and of the 15 cases, five recurred 27–60 months after the initial diagnosis. Recurrence and progression were associated with histologic transformation to diffuse large cell lymphoma in one case. No significant correlation was identified between treatment response and various clinical and pathologic features. Overall, none of the 26 patients died of lymphoma. One patient died of a concomitant pancreatic carcinoma. Of the remaining 25 patients, 14 were disease free and 11 were alive with disease at a mean follow-up of 43 months. The estimated 5-year diseasefree survival was 62%, and median disease-free survival was 69 months. The estimated 5-year relapse-free survival was 54%, and the median relapse-free survival was 63 months.
The Equal Deepest Vertex First Reboot: Rebooting Network Edge Switches in a Campus Network

Even in the era of Software Defined Network (SDN) or Software Defined Infrastructure (SDI), network edge switches still require to be rebooted for some reasons, e.g., updating a firmware, configuring a special behavior and so on. It may be necessary to clarify how one can shorten downtime of a campus network when many switches in the network require reboots. To this end, this paper proposes the equal deepest vertex first reboot with vertex contraction that can simultaneously reboot many network switches with less overhead downtime. This paper tries to express a campus network in a graph theory fashion, reduce downtime overhead by vertex contraction, and proves that all switches can be rebooted within a finite number of rebooting procedures. This paper presents an implementation of the proposed procedures, and evaluates the proposed method in an actual campus network. The equal deepest vertex first reboot with vertex contraction has appeared to reboot all switches by only 16-second additional overhead out of 109-second downtime in total where the ideal minimum downtime was 93 seconds in an actual campus network where there were more than 300 network switches installed.
Editorial

The limit of detection (LOD) and the limit of quantification (LOQ) indicate two important characteristics of a special analytical method, which we call an assay. For pesticides in food and especially in forensic or environmental sciences, both values characterize the quality of an assay at a very low concentration level. A common misconception is that the LOD is the smallest concentration that can be measured. Instead, it is the concentration at which we can decide whether an element is present or not [1]. The smallest concentration that can be measured is where we can just distinguish a signal from the background.
Social Media Data Mining for Proactive Cyber Defense

: The Internet is constantly evolving, producing many new data sources that can be used to help us gain insights into the cyber threat landscape and in turn, allow us to better prepare for cyberattacks. With this in mind, we present an end-to-end real-time cyber situational awareness system which aims to retrieve security-relevant information from the social networking site Twitter.com. This system classiﬁes and aggregates the data extracted and provides real-time cyber situational awareness information based on sentiment analysis and data analytics techniques. This research will assist security analysts in rapidly and e ﬃ ciently evaluating the level of cyber risk in their organization and allow them to proactively take actions to plan and prepare for potential attacks before they happen.
Correlation of optic nerve head changes in glaucoma patients with asymmetric pupillary light reflex, VEP and visual functions

Background: Glaucoma is defined as a group of eye disease with multifactorial etiology, characterized by an acquired loss of retinal ganglion cells, progressive optic neuropathy with morphological abnormalities in the optic nerve head and, visual field defects, in which raised intraocular pressure(IOP) is modified risk factor. As glaucoma is a silent disease without much signs and symptoms, it is hard to diagnose the condition, especially in developing countries like India. Assessment of visual field defects is made by Perimetry. Asymmetric damage between eyes with glaucoma often results in creating relative afferent pupillary defect (RAPD). Colour vision assessment is done as red-green defects accompanied glaucomatous optic neuropathy. Due to raised IOP retinal nerve fibrebundle entering the optic nerve gets damaged leading to altered Visual evoked potential(VEP) waveforms. Materials and Methods: In this case-control observational study, 100 eyes of 100 patients were included. 50 eyes of 50 patients of primary open angle glaucoma and 50 eyes of 50 patients of control cases were enrolled. Results: The comparison of glaucoma staging system with optic disc changes, asymmetri pupillary light reflex, color vision defect and VEP were found to be clinically significant. Conclusion: Since glaucoma is considered to be second most common cause of blindness in India but having an major advantage of being preventable by early diagnosis and prompt treatment, early diagnostic tools like RAPD, colour vision and VEP have proved to be assistive tool to perimetry and optic nerve head changes in primary open angle glaucoma. Key Word: primary open angle glaucoma; RAPD; VEP; colour vision; perimetry. -------------------------------------------------------------------------------------------------------------------------------------Date of Submission: 30-01-2020 Date of Acceptance: 15-02-2020 --------------------------------------------------------------------------------------------------------------------------------------
Multistep Elastic Analysis of the Nonlinear Out-of-Plane Load-Deflection Behavior of Precast Concrete Insulated Sandwich Panels

■ Load-deflection relationships predicted using the proposed analysis method were compared to the authors’ results from out-of-plane flexural testing of panel specimens and to experimental results reported by other investigators. Precast concrete insulated sandwich panels (ISPs) are a cladding system used to protect buildings from moisture ingress and heat loss. These panels are typically made of rigid insulation between two concrete layers. Mechanical connectors connect the concrete layers to each other. Like all cladding systems, these panels are subjected to out-of-plane wind and seismic loads. The out-of-plane loads induce out-of-plane shear forces and bending moments in the precast concrete ISP, thereby producing interlayer shear forces that are primarily transferred between the concrete layers by the mechanical connectors.
Austria Title : Factors of Success for Health Impact Assessments in the Area of Transport

Impact Assessment in the Digital Era 35 Annual Conference of the International Association for Impact Assessment 20 ‐ 23 April 2015 | Firenze Fiera Congress & Exhibition Center | Florence | Italy | www.iaia. org Authors: Gangl Daniela, Amort Frank M. , Neuhold Bianca Graduate of the master-program “Health Management in Tourism” at the University of Applied Sciences in Styria, Austria Institute Health and Tourism Management, University of Applied Sciences in Styria, Austria
Nove anos de Leptospirose no Instituto Biológico de São Paulo

Foram relatados os trabalhos sobre Leptospirose realizados no Instituto Biológico de São Paulo, no período de janeiro de 1960 a dezembro de 1968. Durante o período foram examinados 21263 soros, com uma taxa de positividade de 22,4 %, dentre várias espécies animais, inclusive o homem. O maior número de soros testados foi de bovinos, com 23,6 % de positivos e com uma predominância do sorotipo wolffi, em três casos, aglutinando a 1/12800. O título maior, porém, foi visto em um soro que aglutinou a 1/25600 para o sorotipo pamona. Em suínos, a taxa de positividade foi de 19,5 %, tendo em primeiro lugar o sorotipo pamona, sendo que o maior título encontrado foi de 1/409600. Em equinos encontraram-se 22,8 % de positivos predominando também pomona; neles foi vista também uma correlação entre soros positivos e oftalmia periódica. Em ovinos predominou o sorotipo canicola e a taxa de positivos foi de 39,8 %, enquanto que em caninos foi de 14% na maioria dos casos para icterohaemorrhagiae. Foram apresentados, em cinco quadros demonstrativos, detalhes dos resultados; em outro quadro, o número de soros recebidos de outros Estados, bem como número de positivos e respectivas percentagens. Ao lado das reações sorológicas, muitas foram as tentativas de isolamento. O número de cepas isoladas, assim como os sorotipos encontrados e sua origem foram demonstrados em quadro.
Incorporating Multiple Feature Groups to a Siamese Neural Network for Semantic Textual Similarity Task in Portuguese Texts

The Semantic Textual Similarity (STS) algorithms have a key role in Natural Language Processing (NLP) studies since it can support various NLP tasks such as Text Summarization and Information Retrieval. Although we found several STS initiatives in the literature, just a few authors explored Siamese Neural Networks (SNN) to solve this problem, especially for the Portuguese language, even considering their lower need for training data and an architecture built for similarity tasks. We defined a set of lexical, semantic, distributional and graph-based feature groups to capture distinct aspects of the text and incorporated to a SNN architecture to perform STS in ASSIN 1 and ASSIN 2 datasets. The experiments indicate positive results since we improved the results of previous attempts of STS using SNNs in Portuguese texts.
Continuation and maintenance treatments for persistent depressive disorder

: This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects of pharmacological and psychological continuation and maintenance treatments for persistent depressive disorder, in comparison with each other; placebo (drug/attention placebo/non‐specific treatment control); and treatment as usual (TAU). In addition, to assess the effects of combined psychological and pharmacological continuation and maintenance treatments, in comparison with either of these treatments alone. Continuation maintenance treatments persistent depressive disorder. To assess the effects of pharmacological and psychological continuation and maintenance treatments for persistent depressive disorder, in comparison with each other; placebo (drug/attention placebo/non-speciﬁc treatment control); and treatment as usual (TAU). In addition, to assess the effects of combined psychological and pharmacological continuation and maintenance treatments, in comparison with either of these treatments alone.