Miracle-dz/UniFAR-FTUs huggingface dataset:
EVALUATION OF A REVERSE TETRACYCLINE INDUCIBLE SYSTEM IN RECOMBINANT BCG TO IMPROVE STABILITY AND IMMUNOGENICITY

X CHAPTER 1: A REVIEW ON BCG AS A TB AND A LIVE BACTERIAL VACCINE 1 CHAPTER 2: A REVIEW ON REGULATION OF GENE EXPRESSION IN MYCOBACTERIA 29 CHAPTER 3: CONSTRUCTION AND ASSESSMENT OF THE EPISOMAL TETRR1.12 DEPENDANT REGULATORY SYSTEMS 45 CHAPTER 4: CONSTRUCTION AND EVALUATION OF THE EPISOMAL MULTICOPY HIV-TETR SYSTEMS 86 CHAPTER 5: IMMUNOGENICITY STUDIES OF RBCG HIV-1 SUBTYPE C VACCINE IN BALB/C MICE 107 CHAPTER 6: SUMMARY AND CONCLUSION 134 APPENDICES 136 REFERENCES 156
CMOS Image Sensor Performance from Different Order of Interpolation and Noise Reduction

Three noise reduction programs based on Color Filter Array (CFA) image from Complementary Metal-Oxide-Semiconductor (CMOS) image sensor system are proposed. Imaging performance from different order of interpolation and noise reduction is researched. The relevant models are established and three interpolation methods and four noise reduction methods are selected in the paper. The results show that under different imaging sequence, whether from objective evaluation or from the subjective point of view, Linear Filtering noise reduction is the worst, noise reduction on Least Squares Method is optimal. The conclusions have references to digital camera imaging.
A Novel Neuro-Wavelet-Based Self-Tuned Wavelet Controller for IPM Motor Drives

This paper presents a hybrid neuro-wavelet scheme for online tuning of a wavelet-based multiresolution proportional integral derivative (MRPID) controller in real time for precise speed control of an interior permanent-magnet synchronous motor (IPMSM) drive system under system uncertainties. In the proposed wavelet-based MRPID controller, the discrete wavelet transform (DWT) is used to decompose the speed error between actual and command speeds into different frequency components at various scales of the DWT. The MRPID controller parameters are tuned online by the wavelet neural network (WNN) to ensure optimal performance of the drive system. The neurowavelet-based MRPID controller is trained online with adaptive learning rates in the closed-loop control of the IPMSM drive system. The adaptive learning rates are derived using the discrete Lyapunov stability theorem so that the convergence of speed tracking error could be guaranteed in the closed-loop system. The performance of the proposed hybrid controller is investigated in both simulation and experiments at different dynamic operating conditions. The complete vector control scheme incorporating the proposed self-tuning MRPID controller is successfully implemented in real time using the digital signal processor board ds1102 for the laboratory 1-hp interior permanent-magnet motor. The superior performance of the proposed WNN-based self-tuning MRPID controller is also validated over fixed-gain controllers.
Operation of a dual excitation multiphase electrostatic drive by amplitude‐modulated ac voltage

筆 者 らは軽 量高 出力 モ ー タの 開発 をめ ざ し,様 々 な タイ プの静電 モ ー タの開発 を行 って いる。 それ らの 中で,交 流 駆動両電極形 静電 モー タは,パ ワー密度230W/kg(1)や,推 力 32kgf(2)が実現 されて お り,従 来 の電 磁形 モ ー タに替 わ りう る軽量 ・高 出力 モー タと して期 待 され てい る。 これ まで に 筆者 らが 考案 して きた同期 モ ー タの 一種 で ある このモ ー タ の様 々な駆動方法ωの中 で,1周 波 数法 は単一 周波数 の3相 交流電圧 を電極 に印加 すれ ばそ の周波 数 に比例 した同期 速 度 が得 られ る最 も簡 易 か つ 有効 な駆 動 方 法 で あ る。 しか し,印 加 す る交 流電 圧 の周波 数 が低 くなる低速 の駆 動 にお いて,交 流 高電 圧 を得 るた め に変圧器 を利 用 で きない,推 力が低 下す る な どの 問題 が あ る。 これ らの問題 を解 決す る 方法 として,新 た に変調 駆動 法 を考案 したので,そ の基本 概念,推 力 特性 に関 して報告 す る。
Single event upset immunity of strontium bismuth tantalate ferroelectric memories

An embedded 1 Kbit nonvolatile (NV) serial memory manufactured with strontium bismuth tantalate (SBT) ferroelectric (FE) technology was shown to be immune to effects of heavy ion irradiation. The memories did not lose any data in the non-volatile mode when exposed to xenon (maximum effective LET of 128 MeV-cm/sup 2//mg and a total fluence of 1.5/spl times/10/sup 7/ ions/cm/sup 2/). The ferroelectric memories also did not exhibit any loss in the ability to rewrite new data into the memory bits, indicating that no significant degradation of the FE dipoles occurred as a result of the heavy ion exposure. The fast read/write times of FE memories also means that single event gate rupture is unlikely to occur in this technology.
Race-Related Differences Between and Within Sex to Experimental Thermal Pain in Middle and Older Adulthood: An Exploratory Pilot Analysis

This brief report details a pilot analysis conducted to explore racial differences in pain sensitivity and unpleasantness between cognitively healthy Black and White adults, stratified by sex. A total of 24 cognitively healthy adults (12 Black and 12 White) from two completed studies were matched by age and sex, and divided into two groups based on race. Stratified analyses by sex demonstrated that Black females reported experiencing pain intensity ratings of all three intensity sensations at lower temperatures than White females. These findings will inform future research studies to determine if these results hold true in a fully-powered sample and should include mixed methodologies, incorporating neuroimaging data to further assess this phenomenon. Improving pain assessment and management across racial/ethnic groups will help healthcare providers such as nurses and physicians to ensure optimal quality of life for all.
Review on Arteriovenous Fistula Techniques and Complications

The purpose of long-term vascular access is to provide repeated access to the circulation with the least adverse effects. An arteriovenous fistula is the most preferred vascular access for the initial choice of chronic hemodialysis access. This is because it is favorable for long-term use and consistent with patients’ characteristics and preferences. Moreover, it is easy to create and accompanied with minimal complications. The formation of the AV fistula necessitates adequate arterial and venous anatomy, as well as ample time for the AV fistula to mature before being used. Continuous monitoring is important to assess the functionality of AV fistula and to identify and treat associated complications. We aimed to review the literature for the different types of arteriovenous fistula, and the procedure and techniques in creating them. We also focused on the complications associated with arteriovenous fistula. Articles were chosen from the PubMed database, and selected studies were subjected to a thorough review. Patients with endstage renal disease rely on hemodialysis for survival. For hemodialysis, there are various types of vascular access. An arteriovenous fistula is one of these, and it can be placed in a variety of locations. The decision to use an AV fistula should be individualized based on the patient’s characteristics and physical evaluation. Moreover, continuous monitoring is crucial to promote the function of this vascular access.
Combination of Type I and Type II MET Tyrosine Kinase Inhibitors as Therapeutic Approach to Prevent Resistance

MET-targeted therapies are clinically effective in MET-amplified and MET exon 14 deletion mutant (METex14) non–small cell lung cancers (NSCLCs), but their efficacy is limited by the development of drug resistance. Structurally distinct MET tyrosine kinase inhibitors (TKIs) (type I/II) have been developed or are under clinical evaluation, which may overcome MET-mediated drug resistance mechanisms. In this study, we assess secondary MET mutations likely to emerge in response to treatment with single-agent or combinations of type I/type II MET TKIs using TPR-MET transformed Ba/F3 cell mutagenesis assays. We found that these inhibitors gave rise to distinct secondary MET mutant profiles. However, a combination of type I/II TKI inhibitors (capmatinib and merestinib) yielded no resistant clones in vitro. The combination of capmatinib/merestinib was evaluated in vivo and led to a significant reduction in tumor outgrowth compared with either MET inhibitor alone. Our findings demonstrate in vitro and in vivo that a simultaneous treatment with a type I and type II MET TKI may be a clinically viable approach to delay and/or diminish the emergence of on target MET-mediated drug-resistance mutations.
Form Finding and Analysis of Tension Structures by Dynamic Relaxation

The paper describes numerical procedures, based on the method of dynamic relaxation with kinetic damping, for the form finding, analysis and fabrication patterning of wide-span cable nets and grid shells, uniform or variably prestressed fabric membranes and battened membrane roofs. The historical development of the method is briefly reviewed and a full description is then given which accounts for cable or strut elements, membrane elements and spline beam elements. All of these elements are implemented in their natural stiffness form allowing for gross geometrical and material non-linearities, with automatic controls to ensure stablility and convergence of the method.
THE INFLUENCE OF FLEXIBLE APPENDICES ON A VELOCITY BASED LYAPUNOV FEEDBACK CONTROLLER FOR A VSCMG SYSTEM

A multibody approach based on both Newton-Euler and Lagrange equations is here used to develop a set of decoupled equations describing a flexible satellite platform equipped with a number of rigid fly-wheels. The equations are then used to test the behavior of the ”velocity based” attitude control law recently developed in the framework of rigid bodies and able to successfully steer RW, CMG and VSCMG systems. Interactions between the control system and the flexibility of the structure are underlined in some particular cases.
An advanced approach to power module packaging

Chip-on-flex power overlay technology, the advanced power electronic packaging technology developed at GE CRD, eliminates the need for wire bonds, offers low inductance strip-lined power electrodes, and low parasitic impedance. In addition, the planarity of the top layer structure and the thermal base provide double-sided cooling capability and improve the size, weight, cost, and thermal and electrical performance of the package.
Environment of origin and domestication affect morphological, physiological, and agronomic response to water deficit in chile pepper (Capsicum sp.)

Global climate change is having a significant effect on agriculture by causing greater precipitation variability and an increased risk of drought. To mitigate these effects, it is important to identify specific traits, adaptations, and germplasm that improve tolerance to soil water deficit. Local varieties, known as landraces, have undergone generations of farmer-mediated selection and can serve as sources of variation, specifically for tolerance to abiotic stress. Landraces can possess local adaptations, where accessions adapted to a particular environment will outperform others grown under the same conditions. We explore adaptations to water deficit in chile pepper landraces from across an environmental gradient in Mexico, a center of crop domestication and diversity, as well in improved varieties bred for the US. In the present study, we evaluated 25 US and Mexico accessions in a greenhouse experiment under well-watered and water deficit conditions and measured morphological, physiological, and agronomic traits. Accession and irrigation regime influenced biomass and height, while branching, CO2 assimilation, and fruit weight were all influenced by an interaction between accession and irrigation. A priori group contrasts revealed possible adaptations to water deficit for primary branching, CO2 assimilation, and plant height associated with geographic origin, domestication level, and pepper species. Additionally, within the Mexican landraces, the number of primary branches had a strong relationship with precipitation from the environment of origin. This work provides insight into chile pepper response to water deficit and adaptation to drought and identifies possibly tolerant germplasm.
Private firm accounting: the European reporting environment, data and research perspectives

This study provides a guide to accounting research on private firms with an emphasis on the European setting. We start by providing an overview of private firm financial reporting regulation in Europe and indicate how this institutional framework can be used to identify promising research settings that in part generalise beyond the European setting. Next, we discuss the availability of private firm accounting data and the underlying data generating process that involves private firms’ original reports, governmental and private data aggregators, and commercial data providers. We show how this process generates insightful data, but at the same time causes complex sample selection issues that researchers should take into account when assessing prior findings and developing new research projects. Finally, we identify potential areas of future work by reviewing the extant literature along the three main motivations for conducting private firm work: (i) to learn more about private firms per se, (ii) to learn more about what distinguishes private firms from public firms, and (iii) to obtain insights from private firms that generalise across all firms.
Coordinatively Unsaturated Hf-MOF-808 Prepared via Hydrothermal Synthesis as a Bifunctional Catalyst for the Tandem N-Alkylation of Amines with Benzyl Alcohol

The modulated hydrothermal (MHT) synthesis of an active and selective Hf-MOF-808 material for the N-alkylation reaction of aniline with benzyl alcohol under base-free mild reaction conditions is reported. Through kinetic experiments and isotopically labeled NMR spectroscopy studies, we have demonstrated that the reaction mechanism occurs via borrowing hydrogen (BH) pathway, in which the alcohol dehydrogenation is the limiting step. The high concentration of defective −OH groups generated on the metallic nodes through MHT synthesis enhances the alcohol activation, while the unsaturated Hf4+, which acts as a Lewis acid site, is able to borrow the hydrogen from the methylene position of benzyl alcohol. This fact makes this material at least 14 times more active for the N-alkylation reaction than the material obtained via solvothermal synthesis. The methodology described in this work could be applied to a wide range of aniline and benzyl alcohol derivates, showing in all cases high selectivity toward the corresponding N-benzylaniline product. Finally, Hf-MOF-808, which acts as a true heterogeneous catalyst, can be reused in at least four consecutive runs without any activity loss.
Adaptive partitioning‐based copy‐move image forgery detection using optimal enabled deep neuro‐fuzzy network

The emergence of photo editing applications, like Adobe Photoshop, has manipulated the operation of digital images into a simple task. However, these manipulations of images misrepresent the content of the original image for misleading the public. Various copy move forgery detection techniques are developed, but these show less robustness on the image with noise and blurring. This article develops an optimization‐driven deep learning technique for image forgery detection. The purpose is to develop a copy‐move image forgery detection technique using a deep neuro‐fuzzy network and a newly developed optimization algorithm. Here, adaptive partitioning is adapted using a rectangular search for splitting the image into different parts. In addition, the features like local Gabor XOR pattern and Texton features are extracted from the partition. Furthermore, the forgery is detected using the deep neuro‐fuzzy network. Finally, the deep neuro‐fuzzy network training is performed using the proposed multi‐verse invasive weed optimization (MVIWO) technique. The proposed MVIWO method will be newly designed by integrating the multi‐verse optimizer and invasive weed optimization technique. Thus, the copy‐move image forgery detection is effectively performed using the proposed MVIWO‐based deep neuro‐fuzzy network. The developed MVIWO‐based deep neuro‐fuzzy network offers superior performance with the highest specificity of 93.54%, highest accuracy of 94.01%, and highest sensitivity of 97.75%.
NRC's 3D technology for museum and heritage applications

The National Research Council of Canada (NRC) has developed a range of 3D imaging technology tools, which have been applied to a wide range of museum and heritage recording applications. The technology suite includes the development of high-resolution laser scanner systems as well as software for the preparation of accurate 3D models and for the display, analysis and comparison of 3D data. This paper will offer an overview of the technology and its museum and heritage applications with particular reference to the 3D examination of paintings and recording of archaeological sites.
Improved analytical modelling of rotor eddy current loss in brushless machines equipped with surface-mounted permanent magnets

An improved analytical model for predicting the rotor eddy current loss in brushless machines equipped with surface-mounted permanent magnets is presented. It is formulated in polar co-ordinates and based on the calculation of the two-dimensional electromagnetic field in the airgap/magnet regions, with due account of the eddy current reaction field. It enables the eddy current loss in the permanent magnets and the retaining sleeve, if fitted, to be calculated, and caters for motors having either overlapping or non-overlapping stator windings, as well as any specified load condition. The analysis accounts for both time and space mmf harmonics, but neglects the influence of stator slotting. The model is applied to a brushless DC traction machine in which the rotor loss is due predominantly to time harmonics in the armature reaction field which result from commutation events. The predicted rotor loss is compared with the loss deduced from thermometric measurements and from an analytical magnetostatic model which neglects the eddy current reaction field. Good agreement between predictions and measurements is achieved over the complete operating speed range.
ORAL DELIVERY OF SILVER NANOPARTICLES – A REVIEW

Silver nanoparticles (NP) offer many applications in the science and technology. Oral delivery of such tiny particles results in enhanced drug absorption, reduction in dose, and minimize adverse effects. This review focuses on the mainly on the effects in the gastrointestinal tract along with its in vitro and in vivo studies carried on the silver NP. In this review, we compiled some of the extensive research in the field of silver NP, highlighting some of the most recent trends in the area. Search was carried in English language using Science direct, PubMed, and Google scholar search engines. The effects of silver NP on gastrointestinal tract such as absorption, distribution, metabolism, and elimination were compiled in this review. In addition, selected in vitro and in vivo studies related to the same are discussed. The accumulation of silver NP leading to Arginia condition also emphasized in the study. Silver NP and herbal silver NP in oral delivery can be exploited for the further safer and effective treatment.
Tool–workpiece contact detection in micro-milling using wireless-aided accelerometer sensor

Detection of tool–workpiece contact before the start of precision machining application is essential as it prevents tool breakage and aids in maintaining the accuracy of the machined workpiece. In this research, a wireless-aided three-axis accelerometer attached to a rotating micro-milling tool is used to detect tool–workpiece contact before the start of micro-milling operations. A three-axis accelerometer (ADXL345), an X-Bee pro wireless module and ATMEL328PP-U microcontroller along with other ancillaries were housed on a printed circuit board rigidly attached to a micro-milling tool using couplings. Subsequently, the micro-milling operation was conducted on three different materials, namely, aluminum, copper and brass, for three different revolutions per minute, depth of cut and feed velocity combinations. The accelerometer signals were received wirelessly in a personal computer. Impulsive change in accelerometer signal along Z-axis during machining indicated tool–workpiece contact. The depth of cut of the machined samples was measured using a profilometer. It was found that the setup was accurate in determining tool–workpiece contact at the start of micro-milling operations.
Inversion Spectral Decomposition with Channel Complex Identification

Summary One important application of time frequency analysis is the identification of channel complex. However, conventional time frequency analysis methods suffer from low resolution which sometimes leads to relative terrible interpretation results. In this paper, a novel time frequency analysis approach called inversion spectral decomposition (ISD) is applied to solve these problems. ISD is proposed via inversion strategy and has a higher resolution. In the identification of channel complex, ISD provides not only more detailed time frequency content in time frequency amplitude spectrum than conventional time frequency analysis methods, but also additional phase information, which gives another perspective to identify channel complex, thus reducing the uncertainty in interpretation. In the test of 3D synthetic data, both Gabor transform and ISD are applied to generate time slices. Gabor transform only identifies the middle section of channel complex while ISD clearly identifies the whole channel complex with legible details. Furthermore, ISD provides additional phase information, further confirming the reliability in interpretation. Finally, ISD is applied to a 3D real data, and exhibits an outstanding performance.
A Data-Driven Control Strategy for Urban Express Ramp

Expressway, as the main artery of urban traffic, realizes the smooth operation of the whole urban road network through reasonably balancing the traffic flow. However, due to the lack of reasonable and effective traffic control, the safety and congestion of expressways are becoming more and more serious. The development of intelligent network technology provides a new idea to solve the control problem of expressways. In this paper, a data-driven ramp control model of urban expressway is constructed. The interaction of traffic information is realized through intelligent network connection technology. The cooperative control strategy of VSL and RM is adopted. The mutual feedback of VSL and RM is realized based on the improved METANET model. The simulation experiment based on VISSIM secondary development shows that the collaborative control strategy under the intelligent network environment could make the vehicle travel time reduced by 20.59% and the speed difference between adjacent sections of the expressway mainline by 34.07%, which realized the coordinated control of the mainline and the on-ramp under the intelligent network environment, alleviate the expressway traffic congestion, reduce the traffic pressure, and improve the efficiency of the road network.
Ultra-long-period fiber gratings

We report here for the first time the fabrication and characterisation of long period fiber gratings with periods of several millimetres. The resonant loss peaks of these gratings are generated from the coupling of the forward propagating guided core mode to the cladding modes of fundamental and harmonic orders. These ultra-long-period fiber gratings may find some applications in optical fiber communication and sensing.
Dual‐port dual‐polarized microstrip antenna

Experimental and simulated results for a dual‐port dual‐polarized microstrip antenna are presented. The antenna excites two orthogonally polarized resonant frequencies providing an isolation of ∼30 dB between the ports. The patch geometry consists of two circular arcs of different radii with their centers displaced by a distance. This new design offers an area reduction of ∼70% compared to a standard rectangular microstrip antenna with a reduction in gain of 1.7 dB. © 2002 Wiley Periodicals, Inc. Microwave Opt Technol Lett 34: 459–460, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.10494