Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effects of Perceived Functionality and Usability on Privacy and Security Concerns about Adopting Cloud Application Adoptions

The paper proposes a multi-criteria framework for assessment of Information Technology (IT) offshoring risks from provider’s perspective using the Analytic Network Process (ANP). The authors present an overview of current literature on IT risks in software project development, IT outsourcing and offshoring. Then the network evaluation framework of offshoring risks is outlined and justified. The model is illustrated on a real case of evaluating IT offshoring risks from the point of view of a foreign service provider. The conclusion outlines possible future research directions.
Identification of CIP-1-associated Regulator of Cyclin B (CARB), a Novel p21-binding Protein Acting in the G2 Phase of the Cell Cycle*

The cyclin-dependent kinase inhibitor p21 cip1 regulates cell cycle progression, DNA replication, and DNA repair by binding to specific cellular proteins through distinct amino- and carboxyl-terminal protein binding motifs. We have identified a novel human gene, CARB(CIP-1-associated regulator of cyclin B), whose product interacts with the p21 carboxyl terminus. Immunocytochemical analysis demonstrates that the CARB protein is perinuclear and predominantly associated with the centrosome and mitotic spindle poles. In addition, CARB is also able to associate with cyclin B1, a key regulator of mitosis. However, cyclin B1-CARB complex formation occurs preferentially in the absence of p21. Unexpectedly, overexpression of CARB is associated with a growth-inhibitory and ultimately lethal phenotype in p21−/− cells but not in p21+/+ cells. These data identify a novel mechanism that may underlie the effects of p21 in the G2/M phases of the cell cycle.
iSDF: An integrated software-defined computing framework for scientific experiments

Cloud computing platform is becoming one of the most desired environments for the emerging applications as well as traditional application domains. In this regards, there have been lots of efforts to develop and redesign the framework to deliver solutions that meet a variety of requirements including resilience, performance, and agility. This paper presents a design and implementation of iSDF, an integrated software-defined computing framework for scientific experiments. The iSDF aims at reinforcing traditional cloud-based scheme by supporting application-aware scheduling that avoids resource starvation and contentions for software-defined computing. To demonstrate the effectiveness of the iSDF, we evaluate it by performing several experiments based on three scenarios. The results show that our framework can achieve a 51% increase on resource utilization and average makespan time a 19% improvement compared to the conditions that do not include the policy. Thus, we proved that the framework can contribute to increase utilization for shared resources and to optimize overall makespan time, eventually affecting overall throughput of jobs.
BEHAVIORAL OBSERVATIONS OF SEXUAL ISOLATION AMONG ALLOPATRIC POPULATIONS OF THE MOUNTAIN DUSKY SALAMANDER, DESMOGNATHUS OCHROPHAEUS

The behavioral basis of sexual isolation was investigated in 11 crosses staged between individuals from nine allopatric populations of the Appalachian mountain dusky salamander, Desmognathus ochrophaeus. Scan‐sampled observations of within‐population (homotypic) and between‐population (heterotypic) heterosexual encounters yielded the following results. 1) Fewer heterotypic encounters than homotypic encounters resulted in insemination of females. Indices of the strength of sexual isolation based on insemination data ranged from 0.26 (lowest) to 0.82 (highest), indicating that mechanisms that confer sexual isolation may evolve during allopatric differentiation. 2) Heterotypic encounters that progressed as far as the stage of courtship during which the male stimulates the female to mate did so at the same time as homotypic encounters, although the number of the former reaching this stage was lower. 3) The time interval from courtship initiation to insemination was longer in heterotypic encounters than homotypic encounters. In some crosses, males did not attempt to initiate heterotypic encounters, indicating that this sex is responsible for sexual isolation in these instances. We use our results to formulate specific hypotheses concerning the behavioral basis of sexual isolation in these salamanders, and some possible experimental approaches are suggested.
Substandard artemisinin-based antimalarial medicines in licensed retail pharmaceutical outlets in Ghana.

BACKGROUND & OBJECTIVES The artemisinin-based antimalarial medicines are first line medicines in the treatment of severe and uncomplicated falciparum malaria. Numerous brands of these medicines manufactured in various countries are available in the Ghanaian market. The study was aimed at evaluating the authenticity and quality of selected brands of artemisinin-based antimalarial medicines marketed in Ghana. METHODS In all, 14 artemisinin-based antimalarial medicines were purchased from pharmacies (P) and licensed chemical shops (LCSs) in the Kumasi metropolis, Ghana. Simple field tests based on colorimetry and thin layer chromatography were employed in determining the authenticity of the samples. Important quality assessment tests, namely uniformity of mass, crushing strength, disintegration time, and the percentage content of active pharmaceutical ingredients (APIs) were determined. RESULTS All the brands tested contained the stipulated APIs. Artesunate tablet AT2 failed the uniformity of mass test while artesunate tablets AT3 & AT4 as well as amodiaquine tablets AM4 & AM6 failed the crushing strength test. All the six artemether-lumefantrine tablet brands passed the uniformity of mass, crushing strength and disintegration tests. Only artemether-lumefantrine tablet brand AL1 contained the correct amount of the drugs. The other 13 artemisinin products contained either a lower (underdose) or higher (overdose) amount of the specified drug. Artesunate monotherapy tablets were readily available in pharmacies and licensed chemical shops. INTERPRETATION & CONCLUSION All the artemisinin-based medicines tested (except AL1) were of substandard quality. The results demonstrate the need for continuous monitoring and evaluation of the quality of artemisininbased antimalarials in the Ghanaian market. Also, the practice of artemisinin antimalarial monotherapy is prevalent in Ghana. Determined efforts should, therefore, be made to eradicate the practice to prevent the development of resistance to the artemisinins.
Recent Advances on INSAR Temporal Decorrelation: Theory and Observations Using UAVSAR

We review our recent advances in understanding the role of temporal decorrelation in SAR interferometry and polarimetric SAR interferometry. We developed a physical model of temporal decorrelation based on Gaussian-statistic motion that varies along the vertical direction in forest canopies. Temporal decorrelation depends on structural parameters such as forest height, is sensitive to polarization and affects coherence amplitude and phase. A model of temporalvolume decorrelation valid for arbitrary spatial baseline is discussed. We tested the inversion of this model to estimate forest height from model simulations supported by JPL/UAVSAR data and lidar LVIS data. We found a general good agreement between forest height estimated from radar data and forest height estimated from lidar data.
Stability of the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Questionnaires over 1 year in early middle-aged adults: the CARDIA study.

STUDY OBJECTIVES To describe the stability of the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS) scores over 1 year among a population-based sample of black and white early middle-aged adults. PARTICIPANTS More than 600 participants, aged 38 to 50 years, from the Chicago site of the Coronary Artery Risk Development in Young Adults (CARDIA) Study. METHODS The PSQI and ESS were completed twice, approximately 1 year apart, between 2003 and 2005. Seven PSQI 4-level component scores, a global PSQI score, and the ESS scores were calculated. A PSQI global score greater than 5 was classified as poor quality sleep, and an ESS score greater than 10 was classified as high daytime sleepiness. RESULTS The mean+/-SD PSQI score was 5.7+/-3.1 in Year 1 and 5.9+/-3.1 in Year 2. The mean ESS score was 7.4+/-4.3 in Year 1 and 7.2+/-4.2 in Year 2. The Pearson correlation coefficient for the PSQI score in both years in the full sample was . 68 and ranged from . 54 among black men to . 72 among black women. The Pearson correlation coefficient for the ESS score in both years in the full sample was . 76 and ranged from . 70 among black men to . 80 among white men. In the full sample, 76% had the same PSQI dichotomous classification, and 85% had the same ESS dichotomous classification in both years. CONCLUSIONS These results suggest that the PSQI and ESS are stable measures of sleep quality and sleepiness over the past year in early middle-aged adults.
Using a population‐based registry to identify patterns of care in childhood cancer in Florida

Background. Unlike cancers occurring in adults, childhood cancers are distinguished by being primarily nonepithelial in origin and by their relative rarity. Even with the availability of registries such as the Surveillance, Epidemiology and End Results program of the National Cancer Institute or the Florida Cancer Data System for the State of Florida, there are potential biases that may affect the estimates of pediatric cancer incidence, studies related to elucidating patterns of care, and other epidemiologic studies.
A review of interprovincial variations in HIV prevalence rates in Zimbabwe

Despite the proven remarkable decline of HIV prevalence in the sub-Saharan Africa region, both sub-regional and within-country disparities in HIV prevalence persist. This paper is a survey of literature on HIV prevalence and spread in Zimbabwe, focusing on provincial differences within the national picture of a decline in new infections. In particular, it raises the question of why prevalence and infection rates seem to be disproportionately higher in Matabeleland relative to other provinces of the country. This disparity cannot be adequately explained on the basis of national behavioural analyses as has been the case. The paper suggests possible additional nuances in the forms of analysis and proposes a change of focus in HIV-prevention strategies from national level to provincial considerations of the multiple factors influencing variations in HIV infection rates at provincial level. Using the different contextual conditions between provinces as a way to examine what might be the additional significant variables, the paper brings variations that go beyond sexual behaviour.
Comparison of inflammatory response following coronary revascularization with or without cardiopulmonary bypass.

BACKGROUND It is well known that conventional coronary revascularization is associated with a pronounced systemic inflammatory response due to the application of cardiopulmonary bypass (CPB). OBJECTIVE To compare the effects of coronary artery bypass grafting (CABG) with (on-pump) or without (off-pump) extra-corporeal circulation observing certain inflammatory response parameters. METHODS TWENTY PATIENTS UNDERGOING CABG WITH (CPB GROUP: 10 patients) or without (off-pump coronary artery bypass grafting [OPCAB] group: 10 patients) CPB were enrolled in this prospective, randomized study. Blood samples were collected three times during the operation and on postoperative days 1, 2, 3 and 7. The plasma level of proinflammatory cytokine tumor necrosis factor (TNF)-alpha was measured by enzyme-linked immunosorbent assay method following stimulation, and the expression of adhesion molecules (CD11, CD18) of leukocytes were determined by flow cytometry. Furthermore, white blood cell (WBC) and neutrophil count were carried out. RESULTS The WBC and neutrophil counts rose markedly in both groups following the operation and remained at this increased level during the observation period. There was a significant difference in WBC and neutrophil counts between the two groups of patients on postoperative day 7. A significant difference in the level of TNF-alpha was found between the two groups on postoperative day 2 (P<0.05). An intense increase was observed with CPB, which significantly exceeded the values of the OPCAB group without extracorporeal circulation in the early postoperative period. The CD11a and CD18 expression of leukocytes decreased during the operation and on postoperative day 1; thereafter, it increased markedly. There was a significant difference in adhesion molecule expression between the two groups on postoperative day 2. CONCLUSION The investigation revealed that inflammatory response reactions following extracorporeal circulation could be reduced significantly using the off-pump technique.
The fast multipole method for the wave equation: a pedestrian prescription

A practical and complete, but not rigorous, exposition of the fact multiple method (FMM) is provided. The FMM provides an efficient mechanism for the numerical convolution of the Green's function for the Helmholtz equation with a source distribution and can be used to radically accelerate the iterative solution of boundary-integral equations. In the simple single-stage form presented here, it reduces the computational complexity of the convolution from O(N/sup 2/) to O(N/sup 3/2/), where N is the dimensionality of the problem's discretization. <<ETX>>
Quantifying Cyclic Variability in a Multicylinder HCCI Engine With High Residuals

Cyclic variability (CV) in lean HCCI combustion at the limits of operation is a known phenomenon, and this work aims at investigating the dominant effects for the cycle evolution at these conditions in a multi-cylinder engine. Experiments are performed in a four-cylinder engine at the operating limits at late phasing of lean HCCI operation with negative valve overlap (nvo). A combustion analysis method that estimates the unburned fuel mass on a per-cycle basis is applied on both main combustion and the nvo period revealing and quantifying the dominant effects for the cycle evolution at high CV. The interpretation of the results and comparisons with data from a single-cylinder engine indicate that, at high CV, the evolution of combustion phasing is dominated by low-order deterministic couplings similar to the single-cylinder behavior. Variations, such as in air flow and wall temperature, between cylinders strongly influence the level of CV but the evolution of the combustion phasing is governed by the interactions between engine cycles of the individual cylinders.
The Effect of Blackboard Collaborate-Based Instruction on Pre-service Teachers' Achievement in the EFL Teaching Methods Course at Faculties of Education for Girls

This study investigated the effect of Blackboard-based instruction on pre-service teachers' achievement in the teaching methods course at The Faculty of Education for Girls, in Bisha, KSA. Forty seventh-level English Department students were randomly assigned into either the experimental group (N=20) or the control group (N=20). While studying their teaching methods course, the experimental group received instruction via Blackboard Collaborate, whereas the control group received traditional instruction. The two groups were pre-post tested using a teaching methods test prepared by the researcher. Two hypotheses were formulated and tested. Results obtained from Wilcoxon Signed Ranks Test and Mann-Whitney Test revealed that Blackboard-based instruction was effective in enhancing the achievement of the experimental group. In addition, compared to traditional instruction, Blackboard-based instruction was more effective in improving the participants' achievement as it provided them with multiple opportunities to explore alternative means to interact with teachers, peers, course material and activities.
Great Britain BASAL BODY AND FLAGELLAR DEVELOPMENT DURING THE VEGETATIVE CELL CYCLE AND THE SEXUAL CYCLE OF CHLAMYDOMONAS

Basal body development and flagellar regression and growth in the unicellular green alga Chlamydomonas reinhardii were studied by light and electron microscopy during the vegetative cell cycle in synchronous cultures and during the sexual life cycle. Flagella regress by gradual shortening prior to vegetative cell division and also a few hours after cell fusion in the sexual cycle. In vegetative cells basal bodies remain attached to the plasma membrane by their transitional fibres and do not act as centrioles at the spindle poles during division. In zygotes the basal bodies and associated microtubular roots and crossstriated connexions all dissolve, and by 6-5 h after mating all traces of flagellar apparatus and associated structures have disappeared. They remain absent for 6 days throughout zygospore maturation and then are reassembled during zygospore germination, after meiosis has begun. Basal body assembly in developing zygospores occurs close to the plasma membrane (in the absence of pre-existing basal bodies) via an intermediate stage consisting of nine single Atubules surrounding a central 'cartwheel'. Assembly is similar in vegetative cells (and occurs prior to cell division), except that new basal bodies are physically attached to old ones by amorphous material. In vegetative cells, amorphous disks, which may possibly be still earlier stages in basal-body development occur in the same location as 9-singlet developing basal bodies. After the 9-singlet structure is formed, B and C fibres are added and the basal body elongates to its mature length. Microtubular roots, striated connexions and flagella are then assembled. Both flagellar regression and growth are gradual and sequential, the transitional region at the base of the flagellum being formed first and broken down last. The presence of amorphous material at the tip of the axoneme of growing and regressing flagella suggests that the axoneme grows or shortens by the sequential assembly or disassembly at its tip.
The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase

ABSTRACT The Nrf2 transcription factor promotes survival following cellular insults that trigger oxidative damage. Nrf2 activity is opposed by the BTB/POZ domain protein Keap1. Keap1 is proposed to regulate Nrf2 activity strictly through its capacity to inhibit Nrf2 nuclear import. Recent work suggests that inhibition of Nrf2 may also depend upon ubiquitin-mediated proteolysis. To address the contribution of Keap1-dependent sequestration versus Nrf2 proteolysis, we identified the E3 ligase that regulates Nrf2 ubiquitination. We demonstrate that Keap1 is not solely a cytosolic anchor; rather, Keap1 is an adaptor that bridges Nrf2 to Cul3. We demonstrate that Cul3-Keap1 complexes regulate Nrf2 polyubiquitination both in vitro and in vivo. Inhibition of either Keap1 or Cul3 increases Nrf2 nuclear accumulation, leading to promiscuous activation of Nrf2-dependent gene expression. Our data demonstrate that Keap1 restrains Nrf2 activity via its capacity to target Nrf2 to a cytoplasmic Cul3-based E3 ligase and suggest a model in which Keap1 coordinately regulates both Nrf2 accumulation and access to target genes.
A practical guide for human lab experiments in information systems research: A tutorial with Brownie

Purpose Human lab experiments have become an established method in information systems research for investigating user behavior, perception and even neurophysiology. The purpose of this paper is to facilitate experimental research by providing a practical guide on how to implement and conduct lab experiments in the freely available experimental platform Brownie. Design/methodology/approach Laying the groundwork of the tutorial, the paper first provides a brief overview of common design considerations for lab experiments and a generic session framework. Building on the use case of the widely used trust game, the paper then covers the different stages involved in running an experimental session and maps the conceptual elements of the study design to the implementation of the experimental software. Findings The paper generates findings on how computerized lab experiments can be designed and implemented. Furthermore, it maps out the design considerations an experimenter may take into account when implementing an experiment and organizing it along a session structure (e.g. participant instructions, individual and group interaction, state and trait questionnaires). Originality/value The paper reduces barriers for researchers to engage in experiment implementation and replication by providing a step-by-step tutorial for the design and implementation of human lab experiments.
Neighborhood Effects and the Decision of Women to Work

We examine the influence of neighborhood peer effects on the decision of women to work using 1985-1993 American Housing Survey data that follows clusters of adjacent homes over time. Modeling assumptions imply rank order restrictions on the effect of nearby working and nonworking peers and non-peers that guide the analysis. Estimates indicate that female labor supply is sensitive to peer effects and at least in part because women emulate the work behavior of nearby women with similar age children. For men, peer effects are present in simply specified models but disappear in more robust specifications, consistent with inelastic work decisions. Findings confirm the value of geographically concentrated panel data and other modeling features when attempting to identify peer effects.
Modeling of Resource Granularity and Utilization with Virtual Machine Splitting

The increasing trend in IT users and their needs for computational power in cloud data centers leads to noticeable growth in physical servers. It is a challenging issue which causes the dramatic burden of power consumption and the number of Physical machines. Virtualization is remarkable method for reducing the number of physical servers with appropriate processing performance and utilization. But, it is worth saying that the fulfilling the resource utilization is still one of the significant challenging issue, especially in in data centers environment. Actually, there are some applications situated on a large single virtual machine. One way to guarantee the reasonable physical server utilization is to let the application to be split and hosted on smaller virtual machines with the sufficient computational power. Although exploiting multiple small virtual machine instead of one large virtual machine benefits appropriate physical resources utilization and reducing the number of turn on physical machine, it is sustained penalty in terms of demanding extra resources due to map the applications on new virtual machines. However, existing research have not clarified precisely the reason in terms of that the data center is sustained extra resources and computational power overhead due to splitting the original application and exploiting more smaller virtual machines provided to preserve the criteria of the original application on the large virtual machine. This paper demonstrates through mathematical modelling that the physical resource providers, which are situated in cloud data center, endure the penalty in terms of extra physical resources. The mentioned mathematical modeling in this paper will be noticeable in cloud data center energy efficiency and physical resource utilization performance.