Miracle-dz/UniFAR-FTUs huggingface dataset:
Nonlinear models for morphometric analysis in Bullfrog Tadpoles

As relacoes biometricas sao importantes para ilustrar o processo de crescimento dos animais. Estas, quando ajustadas a modelos nao-lineares, podem revelar informacoes importantes para a melhoria das tecnicas de criacao. O conjunto de dados morfometricos em funcao do peso, de quatro experimentos com girinos de ra-touro, foram ajustados aos modelos nao-lineares de Gompertz, Logistico, Von Bertalanffy e Brody, com objetivo de verificar o melhor ajuste. Apos a adequacao dos parâmetros para os diferentes modelos em cada experimento seguiu-se com a comparacao dos mesmos, por meio dos intervalos de confianca (α = 0,05). Os criterios para selecionar os modelos foram: interpretacao biologica, quadrado medio do residuo, coeficiente de determinacao, analise grafica e o numero de iteracoes. Os dados de comprimentos padrao e total em funcao do peso dos girinos convergiram nos quatro modelos. Os modelos Logistico e Gompertz nao apresentaram interpretacao biologica para alguns conjuntos de dados. O quadrado medio do residuo e numero de iteracoes em todos os experimentos e variaveis estudadas apresentaram os menores valores para o modelo de Brody. Os valores de K dos modelos de Brody para comprimento total, quando comparados ao padrao, apresentaram-se menores, indicando que os animais apresentaram um crescimento inicial maior em comprimento padrao. O modelo de Brody foi o mais indicado para descrever o comprimento padrao e total em funcao do peso para girinos de ra-touro.
A data analysis model based on control charts to monitor online learning processes

This paper discusses the convenience of using data analysis techniques to monitor e-learning processes. It also proposes a model to monitor online students' academic activity and performance. Using data from log files and databases, this model determines which information has to be provided to online instructors and students. These reports allow instructors to: classify students according to their activity and learning outcomes, track their evolution, and identify those who might need immediate assistance. They also provide students with a periodical feedback which makes them aware of how they are performing as compared with the rest of the class.
Cancer genomics: the challenge of drug accessibility

Purpose of review Although significant strides have been made in genome sequencing technology, target-drug matching remains challenging. This article highlights the difficulties associated with patients accessing targeted drugs based on genomic information, and some proposed solutions. Recent findings Although cancers are increasingly stratified according to molecular subgroups, challenges remain in improving patient outcome based on drug-target matching. Before a drug-target match is even proposed, significant expertise is required of the clinician to interpret genomic information. Once a potential match is made, barriers remain for patients to access treatment via clinical trials, as approved agents on-label or off-label, or through expanded access programs. Solutions to improve drug accessibility are actively being investigated. Several prospective trials using molecular characterization as an entry to access target-drug matching are underway. For those unable to access target-drug matching on trial, proposals for a facilitated access program and registry have been suggested. Summary Although improvements have been made in the drug development and approval timelines, drug accessibility based on molecular characterization remains problematic. However, with the emergence of novel trial designs, and efforts to enhance drug access outside of clinical trial settings, opportunities for drug-target matching are improving.
A novel hybrid pass logic with static CMOS output drive full-adder cell

A novel design of a 1-bit full adder cell featuring a hybrid CMOS logic style is proposed. The simultaneous generation of XOR and XNOR outputs by pass logic is advantageously exploited in a novel complementary CMOS stage to produce full-swing and balanced outputs so that adder cells can be cascaded without buffer insertion. The increase in transistor count of the complementary CMOS stage is compensated by its reduction in layout complexity. Comparing with other 1-bit adder cells using different but uniform logic styles, simulation results show that it is very power efficient and has lower power-delay product over a wide range of voltages.
Slack Resources and Firm Growth: The Mediator Role of Organizational Legitimacy

The inconsistent views about the effect of organizational slack (slack resource) on firm growth performance appeal to us explore the relationship by more powerful theoretic. Based on organizational slack theory and organizational legitimacy theory, this paper examines the internal mechanism and path through which organizational slack affects firm growth performance. Through the mediator variable of organizational legitimacy, this study attempts to open the black box of how organizational slack affects pe performance. rformance. Meanwhile, a case discussed contributes to comprehend the key model of this research.
Light energy conversion in Halobacterium halobium

INTRODUCTION . 682 PURPLE MEMBRANE . 683 BACTEBRIORHODOPSIN: A LIGHT-DRIVEN PUMP FOR PROTONS . 686 SECONDARY GRADIENTS: TRANSMEMBRANE MOVEMENTS OF Na+, K', AND Cl. 689 AMINO ACID TRANSPORT . 691 PHOTOPHOSPHORYLATION . 695 RELATIONSHIP BETWEEN BACTERIORHODOPSIN AND THE RESPIRATORY CHAIN . 697 PHOTOTACTIC RESPONSES . 699 BIOSYNTHESIS OF PURPLE MEMBRANE. 699 CONCLUSIONS . 699 LITERATURE CITED . 700
Cancer therapy by means of irreversible tumor blood flow stasis : Starvation tactics against solid tumors

Despite extensive research efforts, effective therapies for advanced cancers have not yet been established, and development of successful treatment strategies remains the most important task in the field of oncology. Three significant problems in conventional chemotherapy using cytotoxic drugs require attention: (i) choosing the most effective drug for individual patients, (ii) delivering a sufficient dose of drug to tumor, and (iii) minimizing severe side effects of anticancer drugs. Because the cancer cells are themselves the direct target of the drugs, these three problems cannot be avoided. We recently showed that AC7700 (currently AVE8062) a derivative of combretastatin A-4, achieved irreversible stasis of tumor blood flow (TBF), thereby causing necrosis of tumor tissue by halting the supply of nutrients. Such effects were unrelated to cancer type, in that they were found for various solid tumors. In this review, we summarize our research on AC7700 and tumor vessels and discuss how AC7700 causes stasis of TBF and why the blood flow does not resume. This technique of attacking tumor by means of blocking TBF largely avoids the three problems typically encountered in conventional cancer chemotherapy that were mentioned above. We propose that such starvation tactics constitute a new therapeutic approach to solid tumors, including refractory cancers which are resistant to conventional cytotoxic drugs and recurrent cancers that have acquired drug resistance.
Power quality enhancement of grid integrated solar PV system based on adaptive noise reduction control

This paper presents implementation of a two stage three phase PV-grid interfaced system with a three phase VSC which has been utilized as a multifunctional device. Adaptive noise reduction technique is used to control multifunctional VSC which transfers the active power from PV system to the grid and also works as an active power filter (APF) to improve power quality at AC mains. The control algorithm presented here has a fast and accurate dynamic response. The proposed SPV energy system has been implemented with linear and non-linear load to show harmonic elimination, load balancing and power factor correction.
Presence of depressive symptoms in patients with a first episode of acute coronary syndrome.

AIM to compare possible differences regarding the presence of depressive symptoms according to the clinical diagnosis of Acute Coronary Syndrome, gender and age, one week before the first cardiac event. METHOD cross-sectional, descriptive and exploratory study, which used the Beck Depression Inventory. The sample consisted of 253 patients. RESULTS it was found that patients with a clinical diagnosis of unstable angina, female and under 60 years of age reported the presence of depressive symptoms more frequently. CONCLUSION a high percentage of patients presented depressive symptoms at the time of hospitalization for the first episode of Acute Coronary Syndrome, and this prevalence was significantly higher among women, under 60 years of age, with unstable angina. These results should provide support for the care in the hospitalization, discharge and planning of the rehabilitation of these patients, as it is known that depression impairs the control of coronary disease.
Isolation and characterization of microsatellite loci from Weigela coraeensis (Caprifoliaceae)

Weigela coraeensis var. coraeensis is a deciduous shrub species distributed in Japan on the mainland, Honshu, whereas its variety W. coraeensis var. fragrans is endemic to the Izu Islands located south of Honshu. We isolated eight polymorphic microsatellite loci from the species and characterized these loci for 20 individuals from a population in Honshu. The number of alleles per locus ranged from 7 to 15 and the observed and expected heterozygosities ranged from 0.60 to 0.90 and from 0.65 to 0.90, respectively. These eight polymorphic microsatellites will be useful for examining intraspecific genetic differentiation in W. coraeensis.
Data Warehouse Interoperability for the Extended Enterprise

The purpose of this paper is to raise awareness and identify a number of challenges regarding the issue of data warehouse interoperation in Web-based collaborative environments. Adopting system and information quality as success variables, we argue that existing works fell short of addressing complex issues that relate to their refreshment and extent far beyond view maintenance solutions within single warehouses. Considering a solution that approaches warehouse refreshment as a business process in a federation of data warehouses, we define a special kind of materialized view that emanates from such an environment, provide a roadmap for implementing the appropriate warehousing architecture, and give some preliminary empirical results.
Physiological Aspects of Aluminium Toxicity on Some Metabolic and Hormonal Contents of Hordeum Vulgare Seedlings

The aim of this investigation is to throw additional light and integrated view on the role of aluminium, as a toxic element in soil, in altering the growth, hormonal and chemical composition of 3 Hordeum vulgare Lcv. Giza 108. The grains were pre soaked in different concentrations of Al2(SO4) (0, 10, 2, 0.4 and 0.08μM) for 6 hr, then sown under controlled conditions in plastic pots. Samples were taken for morphological and chemical analysis when plants were 10 and 30 days old. Lower concentrations of Al either steeply (0.08μM) or slightly (0.4 μM) raised all measured growth criteria (mean length of shoot and root, mean number of leaves and lateral roots and mean fresh and dry weight of plants), the contents of each of chlorophyll a, b, total chlorophyll, total pigments, reducing sugars, starch, total sugars, the levels of each of potassium, magnesium, phosphorus, calcium and growth promoters(auxins, gibberellins, cytokinins) and the activity of invertase enzyme whereas higher concentrations (2 and 10μM) obviously reduced them as comparable to untreated plants.On the contrary, Al at lower concentrations decreased the carotenoid and ABA contents and the activity of IAA-oxidase while higher concentrations elevated them.At the other side, there is a positive correlation between the concentration of Al applied and the accumulation of both sodium and iron and the activities of a and â- amylases.
Comparison of three weight maintenance programs on cardiovascular risk, bone and vitamins in sedentary older adults

Obese patients with knee osteoarthritis (OA) are encouraged to lose weight to obtain symptomatic relief. Risk of vascular events is higher in people with OA compared to people without arthritis. Our aim in this randomized trial was to compare changes in cardiovascular disease (CVD) risk‐factors, nutritional health, and body composition after 1‐year weight‐loss maintenance achieved by [D]diet, [E]knee‐exercise, or [C]control, following weight loss by low‐energy‐diet.
Rapid identification of Serratia marcescens by coagglutination

All 20 O serotypes of Serratia marcescens produce a common, soluble antigen. Crude antigen was obtained by ammonium sulfate precipitation of spent growth medium, antiserum was produced in rabbits, and a coagglutination test for rapid identification of S. marcescens was developed. A total of 701 clinical isolates of gram-negative bacilli were examined, and a 100% correlation between biochemical identification of S. marcescens and identification by coagglutination was found.
Text-learning and related intelligent agents: a survey

In surveying current research in the development of text-learning intelligent agents, the author focuses on three key criteria: what representation the particular application uses for documents, how it selects features, and what learning algorithm it uses. She then describes Personal WebWatcher, a content-based intelligent agent that uses text-learning for user-customized Web browsing.
The Toronto traumatic brain injury study

Objective: To assess the relationship between regional brain volume changes and traumatic brain injury (TBI) severity in patients with and without focal lesions. Methods: Sixty-nine chronic-phase TBI patients spanning the full range of severity were recruited from consecutive hospital admissions. Patients received high-resolution structural MRI a minimum of 1 year after injury. Multivariate statistical analyses assessed covariance patterns between volumes of gray matter, white matter, and sulcal/subdural and ventricular CSF across 38 brain regions and TBI severity as assessed by depth of coma at the time of injury. Patients with diffuse and diffuse plus focal injury were analyzed both separately and together. Results: There was a stepwise, dose–response relationship between parenchymal volume loss and TBI severity. Patients with moderate and severe TBI were differentiated from those with mild TBI, who were in turn differentiated from noninjured control subjects. A spatially extensive pattern of volume loss covaried with TBI severity, with particularly widespread effects in white matter volume and sulcal/subdural CSF. The most reliable effects were observed in the frontal, temporal, and cingulate regions, although effects were observed to varying degrees in nearly every brain region. Focal lesions were associated with greater volume loss in frontal and temporal regions, but volume loss remained marked even when analyses were restricted to patients with diffuse injury. Conclusions: Patterns of parenchymal volumetric changes can differentiate among levels of traumatic brain injury (TBI) severity, even in mild TBI. TBI causes a spatially extensive pattern of volume loss that reflects independent but overlapping contributions of focal and diffuse injury.
Fast multiphase image segmentation model for images with inhomogeneity

This paper presents a fast multiphase segmentation model for inhomogeneous images by incorporating the multiphase formulation of the local and global intensity fitting energy model and the split Bregman method. By applying the globally convex image segmentation idea, we first define a new energy functional, which is then modified by incorporating information from the edge. A weight function that varies dynamically with the location of the image is applied to balance the weights between the local and global intensity fitting terms. The split Bregman method is then applied to minimize our energy functional much more efficiently. Our model can segment more general images accurately, especially images with inhomogeneity. We have applied our model to synthetic and real inhomogeneous images with desirable results. Numerical results demonstrate that our model is superior to the piecewise constant multiphase models and the local binary fitting model. The results obtained by our model are even more accurate than the original local and global intensity fitting energy model.
Beliefs About the Causes and Consequences of Pain in Patients With Chronic Inflammatory or Noninflammatory Low Back Pain and in Pain-Free Individuals

Study Design. Case control study including 2 groups of patients with low back pain (LBP, inflammatory and noninflammatory) and a pain-free community control group. Objective. We explored whether pain beliefs differ between patients with chronic LBP attributed to inflammatory or noninflammatory medical diagnoses, and between patients with chronic LBP and pain-free controls. Summary of Background Data. Beliefs strongly influence patients’ engagement in and response to treatments for chronic LBP. It is unclear, however, whether unhelpful beliefs held by patients with chronic LBP are predominantly associated with diagnosis, or with other aspects of the patient's pain experience. Methods. Patients and controls completed the pain beliefs questionnaire addressing beliefs about the causes and consequences of pain. Patients also completed questionnaires addressing catastrophizing (Coping Strategies Questionnaire), physical disability and bodily pain (SF-36 Health Survey), and psychological distress (Spielberger State-Trait Anxiety Inventory Short Form and Cognitive Depression Index). Variance analysis and &khgr;2 test were used as appropriate, adjusting for effects of covariates and multiple comparisons. Linear regression and logistic regression were used to adjust for confounding factors. Results. Patients with noninflammatory LBP more strongly endorsed organic pain beliefs (e.g., that pain necessarily indicates damage), and catastrophizing (e.g., that the pain is never going to get better), than did patients with inflammatory LBP (P < 0.01). Patients with inflammatory LBP, in turn, more strongly endorsed organic pain beliefs than did pain-free controls (P < 0.05). Endorsement of organic pain beliefs was associated with catastrophizing. Conclusion. Organic pain beliefs are associated with increased catastrophizing in patients with chronic LBP, and addressing these beliefs may help patients to manage their pain and disability. Meanings attributed to inflammatory and noninflammatory diagnostic labels may contribute to the different pain beliefs held by different patient groups.
Fatty acid composition in hybrid pigs as based on local fatty Lithuanian breed and wild boar

The study was designed to investigate the fatty acid composition in longissimus dorsi (LD) and semimembranosus muscles (SM) and subcutaneous tissue of hybrid (1/4 Lithuanian indigenous wattle, 1/4 wild boar and 1/2 Yorkshire or 1/2 Landrace) pigs. The SM showed a tendency to have lower contents of monounsaturated fatty acids (MUFA) and higher contents of polyunsaturated fatty acids (PUFA) than the LD muscle. No statistically significant differences were observed between the muscles in lipid quality indices, i.e., atherogenic (AI) and thrombogenix (TI) indices and the ratio of hypocholesterolemic and hypercholesterolemic fatty acids (h/H). In the SM, the content of PUFA from Yorkshire-sired hybrids was relatively 47.8% higher, including C18:2n-6, C20:4n-6 and DPA (C22:5n-3) that were higher, respectively, by 44.3%, 86.6% and 51.6% in comparison with those from Landrace-sired hybrids. The gilts had a lower content of MUFA, including C18:1 and C20:1n-9 fatty acids in the LD muscle and tended to have a higher content of PUFA in the SM compared to the barrows. Neither the terminal breed in crossing, nor the gender had any significant effects on the proportions of total saturated, MUFA and PUFA in the subcutaneous tissue.
Multi-Projector Imagery on Curved Surfaces

Curved screens are increasingly being used for high-resolution immersive visualization environments. We describe a new technique to display seamless images using overlapping projectors on curved quadric surfaces such as spherical or cylindrical shape. We define a new quadric image transfer function and show how it can be used to achieve sub-pixel registration while interactively displaying two or three-dimensional datasets. Current techniques for automatically registered seamless displays have focused mainly on planar displays. On the other hand, techniques for curved screens currently involve cumbersome manual alignment to make the installation conform to the intended design. We show a seamless real-time display system and discuss our methods for smooth intensity blending and efficient rendering. CR
Developing a Deeper Understanding of Sex Differences in the Diagnostic Performance of Computed Tomographic Perfusion Imaging Toward a More Personalized Approach.

> Continuous improvement is better than delayed perfection. > > —Mark Twain The evaluation of patients with suspected but not yet confirmed of coronary artery disease (CAD) has become increasingly complex in the past decade.1 Multiple noninvasive modalities are now available with individual strengths and weaknesses. Decision making on noninvasive testing when evaluating stable chest pain is further complicated by the observed sex disparity in the clinical presentation, risk factors, and varied role of microvascular dysfunction.2 See Article by Penagaluri et al Coronary computed tomographic angiography (CCTA) is an excellent tool in the exclusion of CAD with unparalleled diagnostic performance3–5 and provide valuable prognostic information.6,7 However the utility of CCTA continues to have 2 important limitations: (1) low specificity in the presence of CAD and (2) lack of lesion-specific physiological assessment. More recently, the introduction of myocardial CT perfusion imaging (CTP) has been shown to augment the information provided by CCTA alone by providing a physiological measure of the significance of a coronary artery stenosis. In the multicentered CORE320 trial (Computed Tomography Angiography and Perfusion to Assess Coronary Artery Stenosis Causing Perfusion Defects by Single Photon Emission Computed Tomography), a combined CCTA-CTP strategy significantly improved the specificity of CCTA alone from 54% to 73%, using invasive coronary angiography and single photon emission CT as the reference standard.8 In this issue of Circulation: Cardiovascular Imaging , Penagaluri et al9 performed an important subanalysis of the CORE320 trial evaluating the diagnostic performance of CCTA-CTP strategy stratified by sex. Interestingly, CTP provided a significant improvement in the discrimination of ischemia in women but not in men (AUC, 0.92 for …