Miracle-dz/UniFAR-FTUs huggingface dataset:
Seminars in Arthritis and Rheumatism

We read with great interest the systematic review and metaanalysis by Altman et al. [1]. The findings presented in this review were very compelling, demonstrating that intra-articular (IA) saline is not a true placebo control in randomized controlled trials (RCTs) of osteoarthritis (OA). Their systematic review and metaanalysis provides a more homogeneous examination of the “placebo” effect of IA saline in RCTs than what was previously described in the literature [2]. The authors identified 40 RCTS, of which 31 trials examined IA corticosteroids, 8 trials examined hyaluronic acid, and only 1 trial examined IA platelet rich plasma. As researchers in the field of IA treatment of painful knee OA, we believe the authors would have provided a more accurate systematic review of the literature by either (a) expanding their search criteria to include all RCTs of IA saline vs. all IA therapies for painful knee OA, or (b) removing the sole article of platelet rich plasma, and revising the title and objectives of the systematic review to reflect the more limited inclusion of trials of corticosteroids and hyaluronic acid therapies. Our own research examining the effect of IA saline vs. IA comparator, a biologic derived from the low molecular weight fraction of human serum albumin, identified a large effect of saline on short-term pain relief (12 weeks in our trial), which was more pronounced in patients with minor OA defined by
Research on Thermal-Field and Sound-Field Coupling Properties of Different Grid Forms

The inlet grid and exhaust grid are widely used in engineering machinery products. The process that airflow goes through grids is a complex turbulent flow and directly related to the heat dispersion and aerodynamic noise. The theoretical analysis result shows that the jet noise generated by airflow has a connection with the grid structure form, fluid flowing situation, and heat conduction. In addition, the influences of different grid structure forms (included the round hole, long hole, and square hole) and porosity on the heat dissipation and aerodynamic noise were analyzed and presented based on the verified computational fluid dynamics (CFD) model. Results show that the heat dispersion and aerodynamic noise of the round hole are most effective under the same porosity; as the porosity increases, the disturbance degree decreases and the noise reduction effect gets better. Finally, the research result provides the scientific basis for improving grid structure and achieving energy saving and noise reduction.
Effects Of Varying Arc Angles And Poles Numbers On Force Characteristics Of Switched Reluctance (SR) Actuator

166605-3535-IJMME-IJENS © October 2016 IJENS I J E N S Abstract— This paper presented the optimum performances of Switched Reluctance (SR) actuator based on the force characteristics. The validations were done by using Finite Element Analysis (FEM) using ANSYS Maxwell 3D software to obtain the distributions of magnetic flux for different configurations. The number of poles and the arc angles parameters are the main concerned. Initially, the number of poles is set to stator-to-rotor (S:R) = 6:4 poles ratio which is then varied by increasing the ratio. In addition, the arc angle for stator (βs) and rotor (βr) were also varied by ±2° degree for each configuration. Based on FEM analysis, the best results were achieved by the SR actuator with the parameters of S: R = 6:4 poles ratio and the arc angles, βs/βr = 30°/41°. This configurations show the highest and most stable increment of force compared to the others configuration.
Compact Antenna with Enhanced Performances Using Artificial Meta-Surfaces

In recent years, artificial meta‐surfaces, with the advantages of smaller physical space and less losses compared with three‐dimensional (3D) metamaterials (MTM), have intrigued a great impetus and been applied widely to cloaks, subwavelength planar lenses, holograms, etc. Typically, one most important part for meta‐surfaces’ applica‐ tions is to improve the performance of antennas. In this chapter, we discuss our effort in exploring novel mechanisms of enhancing the antenna bandwidth using the magneto‐ electro‐dielectric waveguided meta‐surface (MED‐WG‐MS), achieving circular polariza‐ tion radiation through fractal meta‐surface, and also realizing beam manipulation using cascaded resonator layers, which is demonstrated from aspects of theoretical analysis, numerical calculation, and experimental measurement. The numerical and measured results coincide well with each other. Note that all designed antenna and microwave devices based on compact meta‐surfaces show advantages compared with the conven‐ tional cases.
and TEX 101 Quantified in Seminal Plasma Differential Diagnosis of Azoospermia with Proteomic Biomarkers ECM 1

patients with SCO to ineffective surgical interventions. may be able to distinguish patients with OA and NOA, and SCO versus other types of NOA, and thus avoid subjecting seminal plasma that should help facilitate the differential diagnosis of azoospermia. Using these markers, physicians often requires a full surgical procedure. Now, Drabovich and coauthors have identified two protein biomarkers in current technology, the only way to distinguish between these scenarios is to search for sperm within the testis, which from the testis and used for assisted reproduction. In SCO, however, no sperm cells are available for retrieval. With the patient's testes contain any fertile sperm. In cases of OA, and often even HS and MA, sperm can be retrieved Although all of these diagnoses lead to an infertile phenotype in unaided reproduction, they differ as to whether only syndrome (SCO), the patients do not make sperm cells at all. − they do not fully mature. Meanwhile, in Sertoli cell maturation arrest (MA) are types of NOA where some sperm cells are still present, but their number is decreased or (NOA), on the other hand, is caused by abnormalities in the production of sperm. Hypospermatogenesis (HS) and obstruction to the movement of sperm, whereas the sperm cells themselves are normal. Nonobstructive azoospermia different potential treatments. One type of male infertility, obstructive azoospermia (OA), is caused by physical However, male infertility is not a homogeneous disorder, but a collection of diagnoses with different causes and Infertility is a very common medical problem, and male partners are responsible for about half the cases. To Retrieve, or Not to Retrieve, May No Longer Be the Question
Running title : Ig-like domains of the T 9 SS cargo proteins

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/mmi.14083 This article is protected by copyright. All rights reserved. DR. KEIKO SATO (Orcid ID : 0000-0003-3687-4853)
Endometriotic Stromal Cells Methylation of a Novel CpG Island of Intron 1 Is Associated With Steroidogenic Factor 1 Expression in -

Steroidogenic factor 1 (SF-1), a transcriptional factor essential for estrogen biosynthesis, is undetectable in endometrial stromal cells and aberrantly expressed in endometriotic stromal cells. Objective: We tried to gain further insight into the mechanism for differential SF-1 expression in endometrial and endometriotic stromal cells. Design: We had previously identified a novel CpG island in SF-1, which is located in the downstream intron 1 region. Here, we evaluated the methylation status of this CpG island. Patients: We obtained the eutopic endometrium from disease-free participants (n 1⁄4 8) and the walls of cystic endometriosis lesions of the ovaries from another group of participants (n 1⁄4 8). None of the patients had received any preoperative hormonal therapy. Interventions: Stromal cells were isolated from these 2 types of tissues and subjected to DNA bisulfite treatment and sequence analysis. Results: The SF-1 messenger RNA (mRNA) levels in endometriotic stromal cells were significantly higher than those in endometrial stromal cells. Bisulfite sequencing showed strikingly increased methylation of a 1-kbp region around the previously identified CpG island in endometriotic cells compared with endometrial cells (P < .001). A strong correlation between SF-1 mRNA levels and percentage methylation of the intron 1 region of the SF-1 gene was observed in endometriotic cells (Spearman correlation coefficient, .96; P < .001). Conclusions: Methylation of the intron 1 region of the SF-1 gene is associated with its expression in endometriotic cells. This CpG island therefore plays an important role in regulating SF-1 expression.
Simulation analysis on the round billet macrostructure of special steel vertical caster

Original scientific paper This paper provides an analysis of the 42CrMo round billet by the vertical caster. Based on ZhongYuan Special Steel continuous casting process parameters and CAFE nucleation parameters, the ProCAST chip-moving boundary method is adopted to conduct the numerical simulation of round billet. Simulation and practical cases both have the same macrostructure morphology, the round billet has the center equiaxial crystal of 41,2 %. As the superheat of liquid steel and cooling intensity is reduced, the average radius of crystal decreased, the number of crystal increased, and the macrostructure showed a trend of progressive elaboration.
glutamate stimulation Hnrpab regulates neural development and neuron cell survival after Material

The molecular mechanisms that govern the timing and fate of neural stem-cell differentiation toward the distinct neural lineages of the nervous system are not well defined. The contribution of post-transcriptional regulation of gene expression to neural stem-cell maintenance and differentiation, in particular, remains inadequately characterized. The RNA-binding protein Hnrpab is highly expressed in developing nervous tissue and in neurogenic regions of the adult brain, but its role in neural development and function is unknown. We raised a mouse that lacks Hnrpab expression to define what role, if any, Hnrpab plays during mouse neural development. We performed a genome-wide quantitative analysis of protein expression within the hippocampus of newborn mice to demonstrate significantly altered gene expression in mice lacking Hnrpab relative to Hnrpab-expressing littermates. The proteins affected suggested an altered pattern of neural development and also unexpectedly indicated altered glutamate signaling. We demonstrate that Hnrpab neural stem and progenitor cells undergo altered differentiation patterns in culture, and mature Hnrpab neurons demonstrate increased sensitivity to glutamate-induced excitotoxicity. We also demonstrate that Hnrpab nucleocytoplasmic distribution in primary neurons is regulated by developmental stage.
More on the impact of US macroeconomic announcements: Evidence from French and German stock markets' volatility

This paper investigates the impact of US scheduled macroeconomic announcements on the domestic, the French and the German market, respectively using an augmented version of the multivariate DCC-GARCH model. Our setting allows to separate the direct effect (common response), from the indirect effect (volatility transmission) of the US macroeconomic announcements on the two European markets. Empirical results show evidence of a direct reaction of French and German investors to some common as well as specific US macroeconomic news. More interestingly, a significant bidirectional volatility spillover after the release of some macroeconomic news is found to be apparent, either between the US and German markets or between the US and French markets, although the French market shows a more sensitivity to US macroeconomic surprises than the German market. These findings suggest a stronger integration of the US stock market with the French market rather than with the German market.
/sup 87/Rb versus /sup 133/Cs in cold atom fountains: a comparison

We describe the operation of a laser cooled /sup 87/Rb frequency standard and present a new measurement of the /sup 87/Rb ground state hyperfine frequency with a relative accuracy of 2.4/spl times/10/sup -15/, by comparison with a Cs fountain primary standard. The measured frequency is 6 834 682 610.904 333(17) Hz. An evaluation of the frequency shift induced by cold collisions gives /spl Delta//spl nu///spl nu//sub Rb/=(-7.2/spl plusmn/20)/spl times/10/sup -24/ n~, where n~ is the average atomic density in cm/sup -3/. With our present 1 /spl sigma/ uncertainty of 10/sup -15/, this measurement is still compatible with 0 and about 300 times smaller than for /sup 133/Cs. We also report a test of a possible variation of the fine structure constant at the level of 2.7/spl times/10/sup -14/ yr/sup -1/, comparing Rb and Cs cold atom fountains.
International Journal of Systematic and Evolutionary Microbiology Characterization of Desulfovibrio biadhensis sp. nov., isolated from a Tunisian thermal spring

27 A novel anaerobic, mesophilic, slightly halophilic sulfate-reducing bacterium designated 28 strain Khaled BD4 T was isolated from waters from a Tunisian thermal spring. The cells were 29 vibrio-shaped or sigmoids (5-7 x 1-1.5 μm) and occurred singly or in pairs. Strain Khaled 30 BD4 T was Gram-staining-negative, motile, non-sporulated. It grew at temperature between 25 31 and 45°C (optimum 37 °C), at pH between 5.5 and 8.3 (optimum pH 7.0) and with NaCl 32 between 0.5-8% (optimum 3%). It required vitamins or yeast extract for growth. Sulfate, 33 thiosulfate, sulfite and elemental sulfur served as terminal electron acceptors, but not 34 fumarate, nitrate or nitrite. Strain Khaled BD4 T utilized H2 in the presence of 2 mM acetate 35 (carbon source), but also lactate, formate, pyruvate and fumarate in the presence of sulfate. 36 Lactate was incompletely oxidized to acetate. Amongst substrates used, only pyruvate was 37 fermented. Desulfoviridin and c-type cytochrome were present. The G + C content of the DNA 38 was 54.6 mol%. The main fatty acids were anteiso-C15:0, iso-C18:0, iso-C17:0 and iso-C14:0. 39 Phylogenetic analysis of the 16S rRNA gene sequence indicated that strain Khaled BD4 T had 40 Desulfovibrio giganteus (96.7% similarity) as its closest phylogenetic relative. On the basis of 41 the 16S rRNA gene sequence comparisons together with genetic and physiological 42 characteristics, strain Khaled BD4 T is proposed to be assigned to a new bacterial species, for 43 which the name Desulfovibrio biadhensis is proposed. The type strain is Khaled BD4 T (= 44 DSM 28904 T = JCM 30146 T ). 45
Production , Manufacturing and Logistics Production planning with approved vendor matrices for a hard-disk drive manufacturer q

We develop an optimal production schedule for a manufacturer of hard-disk drives that offers its customers the approved vendor matrix (AVM) as a competitive advantage. An AVM allows each customer to pick and choose the various product component vendors for individual or pairs of components constituting their product. The production planning problem faced by the manufacturer is to meet customer demand as precisely as possible while observing the matrix restrictions and also the limited availability of production resources. We formulate this problem as a linear programming model with a large number of variables, and present a solution procedure based on the column generation technique. A special class of the problem is then studied, whereby the number of production setups in each period is limited and discrete. We modify our formulation into a mixed-integer problem, and proceed to develop procedures that can obtain good feasible solutions using linear programming rounding techniques. 2003 Elsevier B.V. All rights reserved.
MPC 1 , a key gene in cancer metabolism , is regulated by COUP-TFII in human prostate cancer

Mitochondrial pyruvate carrier 1 (MPC1) and MPC 2 form a transporter complex in cells to control pyruvate transportation into mitochondria. Reduced expression of MPC1 disrupts the transporter function, induces metabolic shift to increase glycolysis, and thus plays important roles in several diseases, including cancer. However, the role of MPC1 in prostate cancer and the underlying mechanism causing the down-regulation of MPC1 in tumor cells remain to be defined. Here, we show that MPC1 serves as a critical regulator of glycolysis in prostate cancer cells, which in turn controls cancer cell growth, invasion, and the tumorigenic capability. More importantly, we identified that chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII), a steroid receptor superfamily member, transcriptionally regulates the expression of MPC1. We further demonstrate that COUP-TFII, which is upregulated in the prostate cancer patient, regulates MPC1 and glycolysis to promote tumor growth and metastasis. Our findings reveal that COUP-TFII represses MPC1 expression in prostate cancer cells to facilitate a metabolism switch to increase glycolysis and promote cancer progression. This observation raises an intriguing possibility of targeting COUP-TFII to modulate cancer cell metabolism for prostate cancer intervention.
About Contact us My IOPscience You may also be interested in : Robust reference library of a pulsatile physiological signal

Normal functioning of the brain depends on the homeostasis (∼ steady state) of its various physiological sub-systems, one of which is the intracranial pressure (ICP) dynamic system. The ICP dynamic system of an injured brain is susceptible to various acute changes that should ideally be detected by ICP monitoring even for comatose patients. However, the status quo of ICP monitoring solely targets mean ICP. We aimed to demonstrate a novel approach to detect acute deviation from steady state of an ICP dynamic system in an absence of significant mean ICP changes. We hypothesized that steady state of ICP dynamic systems is reflected as ICP pulses of similar mean ICP levels resembling each other for a given subject. A general framework was used to derive such a steady-state indicator that can accommodate different metrics of inter-pulse distance and different statistics of the distance histograms. In addition to conventional Euclidean distance and Pearson correlation, geodesic distance between pulses was introduced as a novel metric. These different ways of calculating steady-state indicators under the proposed framework were evaluated on three types of continuous ICP recordings: (1) those between two consecutive brain imaging studies that demonstrated acute ventricular enlargement for slit ventricle syndrome (SVS) patients undergoing a trial of shunt externalization and clamping (SVS+); (2) those between consecutive brain imaging studies from the SVS patients under the same trial but without ventricular enlargement (SVS−); (3) overnight recordings from normal pressure hydrocephalus (NPH) patients. It was observed that only the standard 4 Author to whom any correspondence should be addressed. 0967-3334/12/122017+15$33.00 © 2012 Institute of Physics and Engineering in Medicine Printed in the UK & the USA 2017
Louis Working Paper Series Nominal Exchange Rate Determinacy Under the Threat of Currency Counterfeiting Pedro Gomis-Porqueras

We study the endogenous choice to accept fiat objects as media of exchange and their implications for nominal exchange rate determination. We consider a twocountry environment with two currencies which can be used to settle any transactions. However, currencies can be counterfeited at a fixed cost and the decision to counterfeit is private information. This induces equilibrium liquidity constraints on the currencies in circulation. We show that the threat of counterfeiting can pin down the nominal exchange rate even when the currencies are perfect substitutes, thus breaking the Kareken-Wallace indeterminacy result. JEL classication: D82, D83, E4, F4.
Seed morphology of Silene commelinifolia Boiss. complex (Caryophyllaceae Juss.)

Silene (Caryophyllaceae) is a large genus with about 700 species distributed worldwide. Auriculatae is the largest section of this genus with 21 endemic species represented in Iran. Seed micromorphology of S. commelinifolia, S. lucida, S. nurensis and S. eremicana from 18 populations was studied by the light microscopy. As a result, 6 populations were adopted for further SEM studies. A great variation was observed in seed shape and size, lateral and peripheral surfaces of seeds, and shape of testa cells edge. Totally, 16 quantitative and qualitative seed features were measured and evaluated. Seed size varied from 1.28 × 1.43 mm in Alvand population of S. eremicana, to 1.97 × 1.50 mm in Bozghosh population of S. lucida. PAST and SPSS software was applied to demonstrate the species relationships. S. eremicana and S. lucida were closely grouped, which is in accordance with their morphological similarities. Seed micromorphology revealed that the species, which are similar to S. commelinifolia are clearly separated from each other. Therefore seed morphology is of taxonomic importance in the studied group.
Thr yttr grin trea

Material and methods. Twenty-four specimens of each of the zirconia and the lithium disilicate ceramic were sectioned from computer-aided design and computer-aided manufacturing blocks into rectangular plates (15 12 2 mm). Twenty-four specimens of the feldspathic porcelain were formed into disks (12 mm diameter) from powders compressed in a silicone mold. All specimens (n1⁄472) were prepared according to the manufacturers’ recommendations. Specimens of each ceramic group were placed into 1 of 3 groups: group R, rough surface finish; group S, smooth surface finish; and group G, glazed surface finish. A total of 9 groups with 8 specimens each were placed in a 3-body wear simulator, with standardized enamel specimens (n1⁄472) acting as the substrate. The wear of the enamel specimens was evaluated after 50 000 cycles. The data were analyzed with 2-way ANOVA and the Tukey HSD multiple comparison test (a1⁄4.05).
Accounting Information , Disclosure , and the Cost of Capital

In this paper we examine whether and how accounting information about a firm manifests in its cost of capital, despite the forces of diversification. We build a model that is consistent with the Capital Asset Pricing Model and explicitly allows for multiple securities whose cash flows are correlated. We demonstrate that the quality of accounting information can influence the cost of capital, both directly and indirectly. The direct effect occurs because higher quality disclosures affect the firm’s assessed covariances with other firms’ cash flows, which is nondiversifiable. The indirect effect occurs because higher quality disclosures affect a firm’s real decisions, which likely changes the firm’s ratio of the expected future cash flows to the covariance of these cash flows with the sum of all the cash flows in the market. We show that this effect can go in either direction, but also derive conditions under which an increase in information quality leads to an unambiguous decline in the cost of capital.