Miracle-dz/UniFAR-FTUs huggingface dataset:
Spatio-temporal structure of fish communities Mochokidae (Ostariophysi, Siluriformes) in the Malebo Pool, Congo River (Democratic Republic of the Congo)

At the level of Malebo Pool of the River Congo, ecological studies of Mochokidae fish communities are non-existent. This study was carried out monthly from July 2009 to October 2010, and bimonthly from March 2011 to August 2013 through experimental fishing in seven lotic and lentic stations to specify the spatio-temporal structure of these relatively abundant fish. Multivariate analysis (Canonical Redundancy Analysis) of Mochokidae stands and their habitats show segregation of species between lotic and lentic areas. The lotic habitats (Nganda Mabanga and Ile Mimosa) are colonised by species such as Chiloglanis congicus, Euchilichthys guentheri, Synodontis brichardi, Synodontis longirostris and Synodontis ornatipinnis that are located in rocky substrates with high current speed. Lentic habitats (Ngamanzo-Japon-Mipongo-Molondo-Kingabwa complex) are colonised by other species such as Synodontis acanthomias, S. decorus, S. alberti, S. notatus, S. congicus, S. caudalis, S. soloni, S. pleurops, S. nummifer and S. contractus that live in muddy and sandy substrates with submerged vegetation and weak current. The study aims to contribute towards better management and conservation of the aquatic ecosystem, specifically the habitat of the Mochokidae species, in light of the negative impacts of human developments in the Democratic Republic of the Congo.
Effect of ADRA2A gene polymorphisms on the anesthetic and analgesic effects of dexmedetomidine in Chinese Han women with cesarean section

It is well known that differences in drug reactions among individuals are widespread, and therefore the study of genetic polymorphisms of drug targets has become a research hotspot. Dexmedetomidine is clinically effective by acting on α2 adrenergic receptor and the impact of the adrenoceptor α2A gene (ADRA2A) polymorphisms on the anesthetic and analgesic effects of dexmedetomidine is related to the clinical application of dexmedetomidine. The present study aimed to analyze the effects of the rs1800035, rs201376588 and rs775887911 locus single-nucleotide polymorphisms of the ADRA2A on the anesthetic and analgesic effects of dexmedetomidine in Chinese Han women. A total of 434 Chinese women undergoing cesarean section were enrolled in this study. A 3-ml fasting venous blood sample was collected from all subjects for genomic DNA extraction and genotype detection. The pre-anesthetic and post-anesthetic pain threshold (PTh), pain tolerance threshold (PTTh), mean arterial pressure, heart rate, blood oxygen saturation, cortisol (Cor) content, blood glucose (Glu) content, opioid usage, patient-controlled analgesia pressing times, surgical satisfaction and postoperative adverse reactions were recorded. The visual analogue scale (VAS) and Ramsay sedation score were evaluated. PTh and PTTh in the wild-type women were higher than those in the women with mutations (P<0.05). The postoperative VAS scores of wild-type women were lower than those of mutants (P<0.05). The Ramsay sedation scores of wild-type patients at 12 h after the operation were significantly higher than in those with mutations (P<0.05). The levels of Cor and Glu in women with mutations were significantly higher than those of wild-type women at 12, 24 and 48 h after surgery (P<0.05). The satisfaction with surgery of wild-type patients was higher than that of patients with mutations (P<0.05). Gene mutations of rs1800035, rs201376588 and rs775887911 loci in the ADRA2A gene reduced the anesthetic and analgesic effect during and after cesarean section in Chinese Han women. Postoperative analgesia of mothers with mutations may require higher doses of analgesics.
Chemical-Source Localization Using a Swarm of Decentralized Unmanned Aerial Vehicles for Urban/Suburban Environments

In this paper, a decentralized chemical-source localization method is presented. In a real-world scenario, many challenges arise, including sporadic chemical measurements due to the complex interactions between the unmanned aerial vehicles (UAVs), the ambient air, and obstacles. The localization method is split into two phases: a search phase, where the agents cover the area and look for an initial chemical reading; followed by a convergence phase, where UAV agents utilize a particle swarm optimization (PSO) algorithm to locate the source of the chemical leak. The decentralized source-localization method enables a swarm of UAVs to safely travel in a complex environment and avoid obstacles and other agents while searching for the leaking source. The method is validated in simulation using realistic dynamic chemical plumes and through outdoor flight tests using a swarm of UAVs. The results demonstrate the feasibility of the approach.
Performance Analysis of Resampling Techniques on Class Imbalance Issue in Software Defect Prediction

Absract — Predicting the defects at early stage of software development life cycle can improve the quality of end product at lower cost. Machine learning techniques have been proved to be an effective way for software defect prediction however an imbalance dataset of software defects is the main issue of lower and biased performance of classifiers. This issue can be resolved by applying the re-sampling methods on software defect dataset before the classification process. This research analyzes the performance of three widely used resampling techniques on class imbalance issue for software defect prediction. The resampling techniques include: “Random Under Sampling”, “Random Over Sampling” and “Synthetic Minority Oversampling Technique (SMOTE)”. For experiments, 12 publically available cleaned NASA MDP datasets are used with 10 widely used supervised machine learning classifiers. The performance is evaluated through various measures including: F-measure, Accuracy, MCC and ROC. According to results, most of the classifiers performed better with “Random Over Sampling” technique in many datasets.
Managing A Business Through Valid Business Decision Making With The Goal Of Achieving Positive Results That Can Be Internationally Valued

Management decisions can speed up the work and business operations of the company. This is achieved by the proper selection of measures and activities undertaken by the management in order to achieve the visible effects of the company's operations in a given observation period. The observation period to be taken is at least one business year. In the period of observation of financial and other reports, companies must have realistic values in the books of account, and the results of these activities must be available to state authorities, banks, tax and other inspectors that at any moment can perform and further control of the activities of the company. Timely business decisions must be made in each period of action. The choices made so far can be seen as a decision-making process within the real-life management of the company. The goal of the approach thus presented is the achievement of the given values that the owners of the company or the founders of the company put before management. Verification of decisions is seen at the end of the observation period. The goal of all management decisions is to maximize the profit and survival of the company.
Phylogeny and Prevalence of Haemosporidian Parasites of Free-ranging Domestic Birds in Northwestern Uganda

Infection of avian malaria parasites is a general problem for both wild and domestic birds. Most infected birds exhibit suppressed immunity, poor productivity and high mortality. Despite this concern, there are limited studies on haemosporidian parasites in free-ranging domestic birds in Africa and its subregions. The aim of this study is to investigate the distribution, prevalence and diversity of haemosporidian parasites among free-ranging domestic birds in Uganda. Blood samples were collected from free-ranging chickens (n=304), ducks (n=70), turkeys (n=14), and guinea fowl (n=19) and screened for haemosporidian parasites. Microscopy and PCR approaches were used to detect and identify parasites based on morphological characteristics and a 600-900 bp amplified fragment of Cytochrome b (cyt b). We detected haemoproteus (17.25%, n=69), plasmodium (22%, n=88) and leucocytozoon (1.75%, n=7) in the sampled birds. The sequences from these genera were nested within their respective clades in a phylogenetic tree constructed using sequences from the MalAvi database. Our study showed that free-ranging domestic birds habour haemosporidian parasites in Uganda thus providing insight for more conscious management practice in poultry systems to prevent widespread infection of the parasites. presence of haemosporidian parasites in free-ranging domestic birds in Northwestern Uganda. We detected Haemoproteus spp. , Leucocytozoon spp. and Plasmodium spp. The Haemosporidian parasites exhibited limited diversity; the phylogeny revealed distinct clades with similar evolutionary relationships. The current level of research and awareness regarding these parasites is low in Uganda therefore requires intensified effort to understand the diversity, prevalence and distribution of haemosporidian parasites in the region.
Targeting p53 in cancer: from innovative yeast screening strategies to new drugs

v RESUMO . vii INDEX . ix INDEX OF FIGURES . xiii INDEX OF SCHEMES . xvi TABLE INDEX . xvii ABBREVIATIONS. xix CHAPTER 1 INTRODUCTION . 1 1.1. Cancer: General concepts . 3 Epidemiology of cancer . 3 Hallmarks of cancer . 4 Anticancer therapeutic strategies . 7 Conventional chemotherapeutic drugs . 8 Targeted anticancer drugs . 10 1.2. The p53 tumor suppressor proteins . 13 Structure of p53 . 14 Functional aspects of p53 . 16 The p53 function under reparable stress . 19 The p53 function under irreparable stress . 21 Regulation of p53 by MDM2 and MDMX. 25 Mutant p53 . 28 Functional activities of mutant p53: LOF, DNE and GOF . 31 1.3. Targeting the p53 pathway . 35 Inhibition of MDMs and of their interactions with p53 . 38 Restoration of wt p53 function to mutant p53 . 42 Combination therapy . 43 Cyclotherapy . 46 1.4. Screening strategies to search for small molecule activators of p53 . 46
Pemrosesan Citra Digital dalam Klasifikasi Hasil Urinalisis Menggunakan Kamera Smartphone

Penelitian ini mengusulkan salah satu pendekatan pengolahan citra dan klasifikasi dalam analisis urin (urinalisis) dengan metode carik celup menggunakan dipstik urin sepuluh parameter (dipstik 10P). Adapun yang diurinalisis dalam pemeriksaan urin meliputi leukosit, nitrit, urobilinogen, protein, keasaman, darah, berat jenis, keton, bilirubin dan glukosa pada urine. Penggunaan kamera yang disematkan pada smartphone dapat menjadi solusi dalam akuisisi citra untuk data reference dan data uji dipstik. Setelah akuisi citra dilanjutkan dengan skema pemrosesan citra dipstik. Citra hasil tangkapan kamera smartphone menempati ruang warna RGB yang selanjutnya digunakan sebagai nilai ekstraksi fitur. Hasil dari ekstraksi fitur warna RGB digunakan sebagai nilai untuk mengukur jarak kedekatan antara reference dan data uji. Metode yang digunakan adalah Jarak Manhattan. Nilai jarak terdekat menjadi solusi dalam masalah klasifikasi hasil urinalisis ini. Perancangan sistem menggunakan bahasa pemrograman Python dengan package OpenCV. Hasil dari perancangan ini menunjukkan sistem dapat melakukan klasifikasi.
Impact of Exercise on Overnight Glycemic Control in Children with Type 1 Diabetes The Diabetes Research in Children Network (DirecNet) Study Group

Objective: To examine the effect of exercise on overnight hypoglycemia in children with type 1 diabetes (T1D). Study Design: At 5 clinical sites, 50 subjects with T1D (11 to 17 years) were studied in a clinical research center on two separate days. One day included an afternoon exercise session on a treadmill. On both days, frequently sampled blood glucose levels were measured at the DirecNet Central Laboratory. Insulin doses were similar on both days. Results: During exercise, plasma glucose levels fell in almost all subjects; 11 (22%) developed hypoglycemia. Mean glucose from 10pm to 6am was lower on the exercise day versus the sedentary day (131 vs. 154 mg/dL, P=0.003). Hypoglycemia developed overnight more often on the exercise nights versus the sedentary nights (P=0.009), occurring only on the exercise night in 13 (26%), only on the sedentary night in 3 (6%), on both nights in 11 (22%), and on neither night in 23 (46%). Hypoglycemia was unusual on the sedentary night if the pre-bedtime snack glucose was >130 mg/ dL. Conclusion: These findings indicate that overnight hypoglycemia post-exercise is common in children with T1D and support the importance of modifying diabetes management following afternoon exercise to reduce the risk of hypoglycemia.
A comparative study on adaptive subject-independent classification models for zero-calibration error-potential decoding

Today, a substantial part of human interaction is the engagement with artificial technological and information systems. Error-related potentials (ErrPs) provide an elegant method to improve such human-machine interaction by detecting incorrect system behaviour from the electroencephalography (EEG) signal of a human operator or user in real time. In this paper, we focus on adaptive subject-independent classification models particularly suitable for the task of ErrP decoding. As such, they provide a promising method to overcome the need of individualized decoding models, which require a time consuming calibration phase. In a comparative study we evaluate the performance of a decoding model solely trained on prior data and the effectiveness of adapting this model to a new subject. Our results show that such a generalized model can decode ErrPs with an acceptable accuracy of $(72.73\pm 5.27){\%}$ and that supervised adaptation can significantly improve the accuracy of the generalized model. Unsupervised adaptation did only prove useful for some subjects with high initial model accuracy and requires more sophisticated methods to be practical for a broader range of subjects. Consequently, our work contributes to the development of calibration-free ErrP decoding, which can potentially be used to improve human-robot interaction.
Maintaining oxidized H3 in heterochromatin is required for the oncogenic capacity of triple-negative breast cancer cells

The histone modification of H3 oxidized at lysine 4 (H3K4ox) is catalyzed by lysyl oxidase–like 2 (LOXL2) and is enriched in heterochromatin in triple-negative breast cancer (TNBC) cells. Although H3K4ox has been linked to the maintenance of compacted chromatin, the molecular mechanism underlying this maintenance is unknown. Here we show that H3K4ox is read by the CRL4B complex, leading to the ubiquitination of histone H2A through the E3 ligase RBX1. Finally, interactions between RUVBL1/2 and LOXL2 are involved in the incorporation of the histone variant H2A.Z, which plays an essential role in the mechanism controlling the dynamics of oxidized H3. Maintenance of H3K4ox in chromatin is essential for heterochromatin properties, and disruption of any of the members involved in this pathway blocks the oncogenic properties of TNBC cells.
A Systematic Review of the Effect of Aromatherapy and Storytelling on Anxiety in Children during Dentistry

Background There is limited study and a lack of systematic review in the field of aromatherapy with orange, and storytelling and their positive effects as a safe, simple and low-cost. The present study is aimed to provide a comprehensive review of the alleviating effects of aromatherapy with orange and therapeutic storytelling on anxiety during dentistry. Materials and Methods: Systemic search of online databases (Medline, Web of Science, Cochrane, EMBASE and Scopus), for randomized control trial and non-randomized prospective or retrospective clinical studies without time and language limitation, using related keyword combinations were searched up to Mar 2019. Two reviewers did study selection and the evaluation of studies was conducted by Jadad scale. Results: Finally,three studies were included in a systematic review. In the first study, salivary cortisol and pulse rate improved significantly in both aromatherapies with and without orange aroma. In the second study, there was no significant difference in the mean of blood pressure, oxygen saturation, and pulse rate between groups (orange essential oil and without aroma) of children during dental treatment; anxiety level was assessed with Venham’s picture scale. Comparison between groups regarding Venham’s picture test was significant. In the third study, there was significant decrease of anxiety, pain and anger in the storytelling psychotherapy group compared with, the placebo and control groups of children receiving treatment by the dentist. Conclusion Both methods, orange odor and storytelling, were effectiveness in decreasing the anxiety level of children receiving dental treatment.
Model Prediction Control Path Tracking Algorithm Based on Adaptive Stanley

Path tracking is an important part of autonomous vehicles. Stanley algorithm is widely used in path tracking control of front wheel steering vehicles. The traditional Stanley algorithm calculates the front wheel angle according to the relative geometric relationship between the vehicle pose and the reference path point, which depends on the nearest reference path point. It is suitable for the low-speed and small change in curvature of reference paths. In order to improve the tracking accuracy and stability of Stanley algorithm, a model predictive control path tracking algorithm based on adaptive Stanley is proposed, which considers the adaptive change of preview distance and vehicle dynamics. The comparative simulation analysis of the proposed control strategy and the traditional Stanley control shows that the model predictive control path tracking algorithm based on adaptive Stanley can maintain high trajectory tracking accuracy and vehicle stability at high speed.
Role of CO-Oximeter in Reduction of Post-Operative Respiratory Complications in Chronic Heavy Smokers

The worldwide number of smokers exceeds one billion, and about 6 million people die per year, due to tobacco use. Smoking and its hazards exert a heavy toll on healthcare expenditure as well, in countries around the world. Patients with a history of smoking have a greater risk for pulmonary complications following surgical procedures. The Conventional technology relies on the use of arterial blood gas (ABG) analysis for monitoring gas saturation parameters in the blood but is invasive, expensive and cumbersome. Pulse CO-oximetry is a widely employed, operator-friendly, non-invasive monitoring method that yields comparable results to laboratory CO-oximetry and facilitates multi-parametric monitoring of the patients. It can accurately measure arterial oxygen saturation levels in heavy smokers who might have higher levels of circulating carboxyhemoglobin. The technology is cost-effective, can facilitate early detection of post-operative pulmonary complications and has the potential to reduce healthcare costs and improve clinical outcomes. Though clinical trials are yet to show benefit in patient monitoring from this technology, it is assumed to hold considerable promise in patients with risk factors for surgical complications.
Investigation of middle school students’ thoughts about a mobile planetarium activity

In this study, students’ thoughts about a mobile planetarium activity were obtained through a letter writing exercise. Document analysis was used to analyse 163 letters by way of content analysis. The study group consisted of 163 students (5th, 6th, 7th and 8th grades) from a middle school in a disadvantaged area of Ankara, Turkey. Analysis of the letters was grouped as what was learnt from the planetarium activity, feelings and thoughts about the planetarium environment, benefits of the activity, and other feelings and thoughts. The students stated that they were generally satisfied with the event, that they enjoyed the activity, were excited, and found it to be extremely fun. Moreover, their interests and curiosity increased due to the activity. The students’ thoughts about the out-of-class activity generated positive feedback and provided effective suggestions for the implementation of similar activities in the future.
Validação da Trait Meta-Mood Scale-24: Estudo com estudantes universitários

Emotional intelligence (EI) is an area of study that has received increasing attention due to the recognition of its potential for promoting adaptation and facilitating the individual's overall emotional well-being and well-being, as well as academic and professional success. However, there are still few studies validating instruments for the assessment of EI in higher education settings. The aim of this study was to adapt and validate the Trait Meta-Mood Scale-24 (TMMS-24) among a sample of Portuguese university students. To this end, the psychometric properties of the TMMS24 were examined in a sample of 682 students (aged between 18 and 58 years, M = 20.33, SD = 2.88), enrolled in the 1st year (40.9%), 2nd year (32.8%), 3rd year (24.6%) and 4th year (1.6%) of an institution of higher education in Porto.The sample was divided into two sub-samples, in which the psychometric properties (sensitivity, reliability and validity) of the EI assessment measure were explored. The results of the exploratory factor analysis and confirmatory factor analysis corroborated the structure of three factors of the original scale (Attention, Clarity and Emotion Repair). In addition, these dimensions showed adequate internal consistency and correlated with each other in the expected direction. The results showed evidence of convergent validity. The TMMS-24 is thus a relevant resource for an effective, rapid, practical and reliable assessment of the self-report of the perception of emotional intelligence in the academic context. Future investigations should seek to expand the sample, assess the stability of the construct and verify whether the number of items in the TMMS-24 should be reduced.
Police Preventative Against Cyber-Bullying Crimes In Indonesia

The impact of bullying action reflects the demeaning behavior of others through various sentences, drawings, and symbols of bullying. The research aims to explain the preventive efforts of cyber-bullying crimes in Indonesia. The method used is qualitative with a descriptive approach to analysis and libraries. Data collection using observation, interview, library, document analysis, participant, and data analysis using descriptive analysis. The results showed that the police should take preventive measures against cyber-bullying so that cyber-bullying crimes could have been prevented early. Preventive police carried out in the form of counseling activities in school institutions, education and institutions, and public places, further socializing the form of print media and online media and campaigning more intensive in schools, campuses, government agencies, and private companies.
Drowsiness Estimation from Respiratory Index Obtained by Using Smart Seat Belt Buckle

In this study, we proposed a method of measuring respiration using a smart seatbelt buckle (SSB) as a method of measuring biometric signals without a load of attachment. The accuracy of the calculated breath time was evaluated, then we attempted to estimate the drowsiness level using the breath time while driving a simulator. As a result, high correlation was obtained between breath times by SSB and band-type thoracoventral respiration sensors measured as a reference. And the possibility to estimate drowsiness level 4 or more was indicated.