Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychotic-like experiences among university female students in Qatar: A qualitative-phenomenological study

Background and aims Psychotic-like experiences (PLEs) are hallucinatory or delusional experiences that fall below the threshold of a diagnosable psychotic disorder. Although PLEs are common across the spectrum of psychiatric disorders, they also have been commonly reported in the general population. In this study, we aimed to describe the types of PLEs experienced by university students in Qatar. Furthermore, we aimed to examine how students frame, explain, and deal with these experiences as well as understand how culture and religion may shape the way students attribute and respond to these experiences. Method This study used a qualitative phenomenological approach. For collecting the data, we conducted semi-structured interviews using the Questionnaire for Psychotic Experiences (QPE). The QPE is a valid and reliable tool to assess the phenomenology of psychotic-like experiences. The questionnaire was translated into Arabic and tested and validated in Qatar (a fast-developing Muslim country in the Arabian Peninsula). We conducted interviews in Arabic with 12 undergraduate female students at Qatar University (the only national university in Qatar). The interviewees were of different Arab nationalities. Interviews were transcribed verbatim and two authors conducted the content-thematic analysis separately, as a strategy to validate the findings. The study was part of a larger nationally funded project that was approved by the Qatar University Institutional Review Board. The approvals were granted before any interview was conducted. Results The PLEs were prevalent in our non-clinical sample. The content-thematic analysis revealed the following main themes about these experiences: type, impact on daily function, frequency, immediate reaction, attribution style, assumptions about the root cause of these experiences, other associations, and religious links to experiences. The results also highlighted that religion and culture play a role in shaping the types of hallucinations and some delusions. Conclusion Our findings support the importance of culture and religion in relation to the types and explanations that students provided when describing PLEs. Notably, it was common among those who reported having these experiences to normalize and link PLEs to real-life events. This may be a defense mechanism to protect the self against the stigma of mental illness and from being labeled as “abnormal”.
Molecular testing for adolescent and young adult central nervous system tumors: A Canadian guideline

The 2021 World Health Organization (WHO) classification of CNS tumors incorporates molecular signatures with histology and has highlighted differences across pediatric vs adult-type CNS tumors. However, adolescent and young adults (AYA; aged 15–39), can suffer from tumors across this spectrum and is a recognized orphan population that requires multidisciplinary, specialized care, and often through a transition phase. To advocate for a uniform testing strategy in AYAs, pediatric and adult specialists from neuro-oncology, radiation oncology, neuropathology, and neurosurgery helped develop this review and testing framework through the Canadian AYA Neuro-Oncology Consortium. We propose a comprehensive approach to molecular testing in this unique population, based on the recent tumor classification and within the clinical framework of the provincial health care systems in Canada. Contributions to the field While there are guidelines for testing in adult and pediatric CNS tumor populations, there is no consensus testing for AYA patients whose care occur in both pediatric and adult hospitals. Our review of the literature and guideline adopts a resource-effective and clinically-oriented approach to improve diagnosis and prognostication of brain tumors in the AYA population, as part of a nation-wide initiative to improve care for AYA patients.
Search for resonant WZ to lvll production using 13 fb−1 in $\sqrt{s}$ = 8 TeV p-p collisions with the ATLAS detector

This dissertation presents a search for a resonant state decaying to a W and a Z bosonusing events with three charged leptons (electrons or muons) and missing transverse energy.The search is performed using proton-proton collisions at a center-of-mass energy of 8 TeV,produced by the LHC and measured by the ATLAS detector in 2012. This data samplecorresponds to an integrated luminosity of 13. {fb^{−1}. Events are selected with reconstructedW and Z bosons found at similar rapidity and large angular separation. The invariantmass of three leptons and missing energy is calculated, assuming on-shell W production,and compared to the Standard Model expectation. No significant excess is observed and theresults are interpreted as cross-section times branching ratio limits for two specific models.In the context of an Extended Gauge Model, a W′ boson is excluded at a 95 % confidencelevel for masses below 1180 GeV. In the context of a Low Scale Technicolor model, two-dimensional limits are set for values of the technipion and technirho mass between 200 GeVand 1000 GeV. These limits are generalizable to any model predicting a narrow resonancethat decays to a W and a Z boson.
Recent advances to enhance the immunomodulatory potential of mesenchymal stem cells

Considering the unique therapeutic potential of mesenchymal stem cells (MSCs), including their immunosuppressive and immunomodulatory properties as well as their ability to improve tissue regeneration, these cells have attracted the attention of scientists and clinicians for the treatment of different inflammatory and immune system mediated disorders. However, various clinical trials using MSCs for the therapeutic purpose are conflicting and differ from the results of promising preclinical studies. This inconsistency is caused by several factors such as poor migration and homing capacities, low survival rate, low level of proliferation and differentiation, and donor-dependent variation of the cells. Enhancement and retention of persistent therapeutic effects of the cells remain a challenge to overcome in MSC-based therapy. In this review, we summarized various approaches to enhance the clinical outcomes of MSC-based therapy as well as revised current and future perspectives for the creation of cellular products with improved potential for diverse clinical applications.
A multi-decadal analysis of river discharge and suspended sediment load in three Texas coastal rivers in relation to hurricanes, seasonal rainfall, and ENSO

Coastal river discharge and sediment load exert major influence on the sustainability of coastal systems. Controlled by various hydroclimatic/hydrometeorological agents, they exhibit distinct trend/variability at different time scales. Coastal Texas, while being a major target for tropical cyclones over the past 6 decades, has been experiencing drought and flood cycles associated with ENSO in the long term. However, it is still unclear the temporal variability of river discharge and the associated sediment delivery over this area at different time scales, and the controlling factors behind it. In this study, a 58-years (1960–2017) dataset is compiled to analyze the influence of ENSO, seasonal rainfall distribution and hurricanes event on the river discharge and suspended sediment load of three Texas coastal rivers-the San Bernard River, the Brazos River, and the Trinity River, at annual, seasonal and event scales, respectively. In the short-term, all three rivers attained the highest average daily discharge and sediment load during Hurricane Harvey. On a seasonal scale, the precipitation regime exerts more influence on the Texas watersheds than tropical storms and hurricanes. Over a multi-decadal scale, amplified rainstorms during the El Niño phases likely play an important role in the overall discharge and sediment transport in large rivers along the northern Gulf coast. Overall, it is reasonable to conclude that the magnitude of hurricane impacts on the overall discharge and suspended sediment load is regulated by the duration and intensity of the rainfall, as well as the coupled drought-flood cycle in relation to the intensity of ENSO.
Oil-degrading bacterial consortium from Gulf of Mexico designed by a factorial method, reveals stable population dynamics

We describe an assembled marine bacterial consortium designed for bioremediation of oil-contaminated seawater, based on a statistical method using a Plackett-Burman (PB) experimental approach. The final consortium consists of four bacteria isolated from the Gulf of Mexico, from four genera: Pseudomonas, Halopseudomonas, Paenarthrobacter, and Alcanivorax. Individually, bacterial oil removal by these microorganisms was evaluated by gravimetry, reaching 39% at maximum after 75 days, whereas in consortium it was ~62%. We also measured biodegradation levels by Gas Chromatography/Mass Spectrometry (GC-MS) observing 12 polyaromatic hydrocarbons (PAHs) degradation analyzed and n-alkanes degradation with a preference for specific chain length. Consortium population analysis using the V3-V4 region of 16S rRNA showed a stable community, suggesting that the metabolic load was distributed among bacteria and that stable dynamic interactions were achieved. In this work, we show that the use of a factorial method for synthetic consortium design offers the possibility of improving oil degradation efficiency with stable bacterial populations.
A composite nodal finite element for hexagons

A nodal algorithm for the solution of the multigroup diffusion equations in hexagonal arrays is analyzed. Basically, the method consists of dividing each hexagon into four quarters and mapping the hexagon quarters onto squares. The resulting boundary value problem on a quadrangular domain is solved in primal weak formulation. Nodal finite element methods like the Raviart-Thomas RTk schemes provide accurate analytical expansions of the solution in the hexagons. Transverse integration cannot be performed on the equations in the quadrangular domain as simply as it is usually done on squares because these equations have essentially variable coefficients. However, by considering an auxiliary problem with constant coefficients (on the same quadrangular domain) and by using a ''preconditioning'' approach, transverse integration can be performed as for rectangular geometry. A description of the algorithm is given for a one-group diffusion equation. Numerical results are presented for a simple model problem with a known analytical solution and for k(eff) evaluations of some benchmark problems proposed in the literature. For the analytical problem, the results indicate that the theoretical convergence orders of RTk schemes (k = 0,1) are obtained, yielding accurate solutions at the expense of a few preconditioning iterations.
Treatment of avulsion fractures of the pelvis in adolescent athletes: A scoping literature review

Avulsion fractures of the pelvis and hip region are typical injuries in adolescent athletes. Avulsion sites include the muscle tendon origin or insertion, and treating these injuries surgically or conservatively remains a debated issue. The main goals of this review were to assess and summarize injury types and sites, treatment-related clinical outcomes, and return to sport for adolescent patients with a pelvis avulsion fracture and to provide support for making treatment decisions. The PubMed database was searched in November 2021 to identify all published articles from 2000 to 2021 that reported the outcome and return to sport after conservative or surgical treatment. Eighteen studies with 453 patients were included in this review. The age range was 13.6–16.8 years. The most common injury site the was anterior superior iliac spine (37%), followed by the anterior inferior iliac spine (31%), ischial tuberosity (14%), lesser trochanter (9%), iliac crest (8%), and superior corner of the pubic symphysis (1%). Overall complications were lower in the surgical group compared to the conservative group. The rate of return to pre-injury activity level was greater in patients who underwent surgical treatment (p < 0.05). In conclusion, surgery is preferred for major dislocation and fragment size, providing a better return-to-sport rate and decreasing the risk of complications.
A centralized local energy storage modular multilevel converter

The energy storage modular multilevel converter (MMC-ES) has been widely studied for its excellent performance in solving the problems of power difference, voltage fluctuation and effective improvement of power quality in the grid caused by the integration of new energy caused by new energy grid connection. Aiming at the problems that energy storage units of the traditional distributed MMC-ES are scattered, inconvenient to assemble and maintain, complex system control, and the traditional centralized MMC-ES has poor capacity selection flexibility, in this paper, a centralized local energy storage modular multilevel converter (MMC-CLES) between the distributed MMC-ES and the centralized MMC-ES is proposed. On the premise of not affecting the advantages of MMC-ES, by reducing the number of energy storage units, the switching loss is reduced, and the problems of complex SOC (state of charge) balance control strategy, large power conversion system loss, the AC side current imbalance caused by the grid connection of new energy sources and high system cost caused by too many energy storage units are solved. Matlab/simulink simulation shows that compared with traditional distributed MMC-ES, MMC-CLES reduces a total of 52 power devices, and under the condition of three-phase voltage unbalance, MMC-CLES effectively suppresses power fluctuations, the SOC balance control and the fast balance of the three-phase current are realized. The unbalance degree of the three-phase current is 8.16%, and the total harmonic distortion rate of the current is 3.11%.
The role of unsustainable HR practices as illegitimate tasks in escalating the sense of workplace ostracism

Unsustainable HR practices impose illegitimate tasks on employees due to a shortage of resources. These illegitimate tasks bring counterproductive work behavior in terms of workplace incivility that creates a sense of ostracism in employees. To address these issues, the study examined the relationship among unsustainable HR practices in terms of illegitimate tasks and workplace ostracism. Whereas workplace incivility is defined as an underlying reason through which this association exists. Adopting a theoretical framework from earlier research, the study used cross-sectional data and subsequently a method of quantitative research, and the sample comprised permanent faculty members of private universities in Pakistan working in different departments with different role titles. Smart PLS was applied to run multiple statistics analyzed on the obtained data. The results from the study supported the hypothesis by depicting a positive and significant association between illegitimate tasks and workplace ostracism. Further, workplace incivility was playing the mediating role between illegitimate tasks and workplace ostracism. The results from the study carry significant implications for managers and researchers. Recommendations and future research directions are also discussed in the paper.
Targeting the innate repair receptor axis via erythropoietin or pyroglutamate helix B surface peptide attenuates hemolytic-uremic syndrome in mice

Hemolytic-uremic syndrome (HUS) can occur as a systemic complication of infections with Shiga toxin (Stx)-producing Escherichia coli and is characterized by microangiopathic hemolytic anemia and acute kidney injury. Hitherto, therapy has been limited to organ-supportive strategies. Erythropoietin (EPO) stimulates erythropoiesis and is approved for the treatment of certain forms of anemia, but not for HUS-associated hemolytic anemia. EPO and its non-hematopoietic analog pyroglutamate helix B surface peptide (pHBSP) have been shown to mediate tissue protection via an innate repair receptor (IRR) that is pharmacologically distinct from the erythropoiesis-mediating receptor (EPO-R). Here, we investigated the changes in endogenous EPO levels in patients with HUS and in piglets and mice subjected to preclinical HUS models. We found that endogenous EPO was elevated in plasma of humans, piglets, and mice with HUS, regardless of species and degree of anemia, suggesting that EPO signaling plays a role in HUS pathology. Therefore, we aimed to examine the therapeutic potential of EPO and pHBSP in mice with Stx-induced HUS. Administration of EPO or pHBSP improved 7-day survival and attenuated renal oxidative stress but did not significantly reduce renal dysfunction and injury in the employed model. pHBSP, but not EPO, attenuated renal nitrosative stress and reduced tubular dedifferentiation. In conclusion, targeting the EPO-R/IRR axis reduced mortality and renal oxidative stress in murine HUS without occurrence of thromboembolic complications or other adverse side effects. We therefore suggest that repurposing EPO for the treatment of patients with hemolytic anemia in HUS should be systematically investigated in future clinical trials.
Soil bacteria are more sensitive than fungi in response to nitrogen and phosphorus enrichment

Anthropogenic activities have dramatically increased nitrogen (N) and phosphorous (P) enrichments in terrestrial ecosystems. However, it is still unclear on how bacterial and fungal communities would respond to the simultaneously increased N and P enrichment. In this study, we used a field experiment to simulate N and P input, and examined the effects of N and P additions on the abundance, alpha-diversity, and community composition of soil bacteria and fungi in a riparian forest. Six nutrient-addition treatments, including low N (30 kg N ha–1 year–1), high N (150 kg N ha –1 year–1), low P (30 kg P2O5 ha–1 year–1), high P (150 kg P2O5 ha –1 year–1), low N+P, high N+P, and a control (CK) treatment were set up. We found that the N and P additions significantly affected bacterial abundance, community composition, but not the alpha diversity. Specifically, 16S, nirK, and nirS gene copy numbers were significantly reduced after N and P additions, which were correlated with decreases in soil pH and NO-3-N, respectively; Co-additions of N and P showed significantly antagonistic interactions on bacterial gene copies; Nutrient additions significantly increased the relative abundance of Proteobacteria while reduced the relative abundance of Chloroflexi. Mantel’s test showed that the alteration in bacterial composition was associated with the changes in soil pH and NO-3-N. The nutrient additions did not show significant effects on fungal gene copy numbers, alpha diversity, and community composition, which could be due to non-significant alterations in soil C/N and total P concentration. In conclusion, our results suggest that soil bacteria are more sensitive than fungi in response to N and P enrichment; the alterations in soil pH and NO-3-N explain the effects of N and P enrichment on bacterial communities, respectively; and the co-addition of N and P reduces the negative effects of these two nutrients addition in alone. These findings improve our understanding of microbial response to N and P addition, especially in the context of simultaneous enrichment of anthropogenic nutrient inputs.
The emotional significant negative events and wellbeing of student teachers during initial teacher training: The case of physical education

Teaching is a demanding job and the aim of the present study was to explore the emotional experiences and wellbeing levels (burnout and vigor) of Physical Education (PE) student teachers in comparison with student teachers of other subjects. In all, 167 student teachers (99 in PE and 68 in other subjects) described two significant professional negative events experienced during the school placement. They also reported the frequency of occurrence of these events, the level of unpleasant emotions related to the events, and their scores of burnout and vigor. The negative emotional events were encoded following an inductive approach and five categories emerged: Student rules violations, Collaborative issues, Physical integrity risks, Organizational issues, and Lack of student motivation. The Chi-square analyses revealed a different distribution in the negative events according to the subject taught, especially including an overrepresentation of Lack of student motivation and Physical integrity risks for PE student teachers and Collaborative issues for other-subjects student teachers. Moreover, Mann-Whitney U-tests revealed a similar frequency of negative emotional events whatever the subject taught, but a lower intensity of unpleasant emotions, lower physical fatigue and higher scores of physical strength for PE student teachers in comparison with those of other subjects. The present findings confirmed that the specificities of PE lead to singular significant negative events for PE students during initial training. Finally, the health outcomes (intensity of unpleasant emotions, burnout and vigor) suggest that PE teachers have developed specific resources to cope with school constraints, probably in relation to their sport experiences.
Breaking down the cell wall: Still an attractive antibacterial strategy

Since the advent of penicillin, humans have known about and explored the phenomenon of bacterial inhibition via antibiotics. However, with changes in the global environment and the abuse of antibiotics, resistance mechanisms have been selected in bacteria, presenting huge threats and challenges to the global medical and health system. Thus, the study and development of new antimicrobials is of unprecedented urgency and difficulty. Bacteria surround themselves with a cell wall to maintain cell rigidity and protect against environmental insults. Humans have taken advantage of antibiotics to target the bacterial cell wall, yielding some of the most widely used antibiotics to date. The cell wall is essential for bacterial growth and virulence but is absent from humans, remaining a high-priority target for antibiotic screening throughout the antibiotic era. Here, we review the extensively studied targets, i.e., MurA, MurB, MurC, MurD, MurE, MurF, Alr, Ddl, MurI, MurG, lipid A, and BamA in the cell wall, starting from the very beginning to the latest developments to elucidate antimicrobial screening. Furthermore, recent advances, including MraY and MsbA in peptidoglycan and lipopolysaccharide, and tagO, LtaS, LspA, Lgt, Lnt, Tol-Pal, MntC, and OspA in teichoic acid and lipoprotein, have also been profoundly discussed. The review further highlights that the application of new methods such as macromolecular labeling, compound libraries construction, and structure-based drug design will inspire researchers to screen ideal antibiotics.