Miracle-dz/UniFAR-FTUs huggingface dataset:
Autophagy-Related Long Non-coding RNA Signature as Indicators for the Prognosis of Uveal Melanoma

This study aimed to develop an autophagy-associated long non-coding RNA (lncRNA) signature to predict the prognostic outcomes of uveal melanoma (UM). The data of UM from The Cancer Genome Atlas (TCGA) were enrolled to obtain differentially expressed genes (DEGs) between metastasizing and non-metastasizing UM patients. A total of 13 differentially expressed autophagy genes were identified and validated in Gene Expression Omnibus, and 11 autophagy-related lncRNAs were found to be associated with overall survival. Through performing least absolute shrinkage and selection operator regression analyses, a six-autophagy-related lncRNA signature was built, and its efficacy was confirmed by receiver-operating characteristic, Kaplan–Meier analysis, and univariate and multivariate Cox regression analyses. A comprehensive nomogram was established and its clinical net benefit was validated by decision curve analysis. GSEA revealed that several biological processes and signaling pathways including Toll-like receptor signaling pathway, natural killer cell-mediated cytotoxicity, and B- and T-cell receptor signaling pathway were enriched in the high-risk group. CIBERSORT results showed that the signature was related to the immune response especially HLA expression. This signature could be deployed to assist clinicians to identify high-risk UM patients and help scientists to explore the molecular mechanism of autophagy-related lncRNAs in UM pathogenesis.
LINC01977 Promotes Breast Cancer Progression and Chemoresistance to Doxorubicin by Targeting miR-212-3p/GOLM1 Axis

Long non-coding RNAs(lncRNAs) play an important role in cancer initiation and progression. However, hub lncRNAs involved in breast cancer still remain underexplored. In this study, integrated bioinformatics analysis was used to define LINC01977 as a key oncogenic driver in breast cancer. Subsequently, in vitro assays showed that LINC01977 could significantly promote breast cancer progression and chemoresistance to doxorubicin. To further investigate its biological mechanism, we performed dual-luciferase reporter assay, real-time PCR, RNA immunoprecipitation (RIP), and rescue assay. Our results indicated that LINC01977 may function as ceRNA to prevent GOLM1 gene from miRNA-mediated repression by sponging miR-212-3p. Overall, LINC01977 can serve as a novel prognostic indicator, and help develop more effective therapeutic approaches for breast cancer patients.
Prediction of Potential and Actual Evapotranspiration Fluxes Using Six Meteorological Data-Based Approaches for a Range of Climate and Land Cover Types

Evapotranspiration is the major component of the water cycle, so a correct estimate of this variable is fundamental. The purpose of the present research is to assess the monthly scale accuracy of six meteorological data-based models in the prediction of evapotranspiration (ET) losses by comparing the modelled fluxes with the observed ones from eight sites equipped with eddy covariance stations which differ in terms of vegetation and climate type. Three potential ET methods (Penman-Monteith, Priestley-Taylor, and Blaney-Criddle models) and three actual ET models (the Advection-Aridity, the Granger and Gray, and the Antecedent Precipitation Index method) have been proposed. The findings show that the models performances differ from site to site and they depend on the vegetation and climate characteristics. Indeed, they show a wide range of error values ranging from 0.18 to 2.78. It has been not possible to identify a single model able to outperform the others in each biome, but in general, the Advection-Aridity approach seems to be the most accurate, especially when the model calibration in not carried out. It returns very low error values close to 0.38. When the calibration procedure is performed, the most accurate model is the Granger and Gray approach with minimum error of 0.13 but, at the same time, it is the most impacted by this process, and therefore, in a context of data scarcity, it results the less recommended for ET prediction. The performances of the investigated ET approaches have been furthermore tested in case of lack of measured data of soil heat fluxes and net radiation considering using empirical relationships based on meteorological data to derive these variables. Results show that, the use of empirical formulas to derive ET estimates increases the errors up to 200% with the consequent loss of model accuracy.
Mini-Map for Gamers Who Walk and Teleport in a Virtual Stronghold

Studies of the effectiveness of multimedia cartography products may include mini-map design for navigation. In this study, we have touched upon designing gameplay to indicate the impact of the mini-map on the time effectiveness of a player that can walk or teleport himself/herself along marked out points in virtual topographic space. The eye-tracking examination of gamers’ effectiveness in a non-complex game of collecting coins in a reconstructed stronghold on the holm provided us with a new perspective on the role of mini-maps. The more time gamers took to examine the mini-map, the more time they needed to finish the game, thus decreasing their effectiveness. The teleporting gamers had significantly higher time effectiveness than walking gamers, however, the data obtained showed only a minor difference between the proportions of the mini-map examination time to the total game time for walking and teleportation.
Transnational Accessibility between Residential Areas Based on Multimodal Transport System

Due to the development of globalization, transnational activities are more frequent and evaluations of current accessibility are the basis for accessibility improvements. Accessibility evaluation indices generally contain two parts: travel time and travel probability. However, complex transnational processes involve the multimodal transport system, including air and land transport networks, which makes the calculation of these indices more difficult because large quantities of fundamental data, in addition to suitable models, are needed. In this study, residential areas were set as the basic evaluation unit for fine-scale and whole-process analysis. Then, multiple web-sourced platforms were introduced to acquire the travel time between each pair of residential areas. The temporal-range radiation model was applied to calculate transnational travel probability by considering spatial interactions of populations. Finally, the weighted-average travel time to South Asia and Southeast Asia (SA&SEA) countries was generated to represent the overall accessibility for each populated area in China. The results showed that China had better accessibility to SEA than SA, and countries with high accessibility were Thailand, Singapore, and Malaysia. In China, southwest, south, and southeast regions showed larger accessibility to SA&SEA. Improvements of accessibility were also indicated by conjoint analysis of airport nodes. The proposed framework can help to delineate the spatial patterns of transnational accessibility and guide the enhancements of accessibility.
A real-time motion planning scheme for collaborative robots using HRI-based cost function

In this paper, we propose a novel scheme for real-time motion planning of a collaborative robot that assists its fellow human worker in performing assembly tasks by delivering parts and tools to the worker. In the proposed scheme, the delivery position of the parts and tools is determined first, based on a cost function relating to the safety, visibility, and arm comfort terms of the worker by solving the non-convex optimisation problem in real-time using a random sampling-based algorithm in the vicinity of the worker's current position. Then, model predictive control (MPC)-based trajectory planner directly generates a collision-free robot trajectory from the current robot configuration to the delivery configuration under velocity and acceleration constraints of the robot. The proposed motion planning scheme is implemented in the actual collaborative robot system and the effectiveness of the proposed scheme is illustrated experimentally.
Microwave Hydrothermal Synthesis and Characterization of Nanosize NiCuZn Ferrites

Ni0.5‐xCuxZn0.5Fe2O4 (x=0,4,6,8,12 mol%) nanoferrite powders were synthesized using microwave‐hydrothermal (M‐H) method. Nanophase ferrites with high surface area were synthesized at 160 °C after a treatment time of 1 h. The ferrite formation conditions such as pH, temperature and time were optimized. The phase identification of the prepared samples was done by X‐ray diffraction, characterized by IR spectra and crystal size and morphology were determined by transmission electron microscopy (TEM). The size of the nanoferrite powders synthesized was 20–60 nm. The nanoferrite powders were conventionally sintered at a temperature of 900 °C/4 h. The variations of the sintered density, saturation magnetization and electrical resistivity as a function of copper concentration at room temperature have been investigated. Dielectric properties were measured in the frequency range of 1 MHz–1.8 GHz and obtained results were understood with the help of available theories.
Effects of Virtual Reality Locomotion Techniques on Distance Estimations

Mental representations of geographic space are based on knowledge of spatial elements and the spatial relation between these elements. Acquiring such mental representations of space requires assessing distances between pairs of spatial elements. In virtual reality (VR) applications, locomotion techniques based on real-world movement are constrained by the size of the available room and the used room scale tracking system. Therefore, many VR applications use additional locomotion techniques such as artificial locomotion (continuous forward movement) or teleporting (“jumping” from one location to another). These locomotion techniques move the user through virtual space based on controller input. However, it has not yet been investigated how different established controller-based locomotion techniques affect distance estimations in VR. In an experiment, we compared distance estimations between artificial locomotion and teleportation before and after a training phase. The results showed that distance estimations in both locomotion conditions improved after the training. Additionally, distance estimations were found to be more accurate when teleportation locomotion was used.
Evidence for short-range orientation effects in dipolar aprotic liquids from vibrational spectroscopy. Part 2.—Carbonyl compounds

In the Raman spectrum of pure liquids, the anisotropic component of the CO stretching band falls at a higher frequency than the isotropic component. In the same liquids the infra-red band maximum appears at almost the same frequency as the Raman anisotropic component. In some cases the infra-red band may be resolved into two components, the stronger coinciding with the anisotropic, the weaker with the isotropic Raman band. These effects disappear with dilution and are reduced with increasing temperature.This behaviour is explained in terms of a model which assumes that dipolar aprotic liquids are composed of clusters of molecules oriented in an (at least partially) ordered way.
Bus Service Level and Horizontal Equity Analysis in the Context of the Modifiable Areal Unit Problem

The modifiable areal unit problem is of great importance in geographic science. The use of a specific zoning impacts the social and economic imbalances that can be generated in the deployment of services, facilities, and infrastructure. In this article, GIS is used together with simulation and optimization tools to analyse the effects of bus frequency changes in the levels of service and horizontal equity derived from different types of territorial zoning. The city of Palma (Balearic Islands, Spain) was chosen as a case study for the method, for which different geographical areas are used: neighbourhoods, census sections, cadastral blocks, and a 400 × 400 m mesh. The results show significant variations of the optimal frequencies obtained, depending on the type of zoning used. In general, smaller zonings show much higher sensitivity for the detection of imbalances between the population and bus service level. Likewise, orthogonal zonings also prove useful for identifying service and population concentration over other zonings. The use of large spatial units could lead to the misdiagnosis of needs and the implementation of actions that do not actually improve the level of service or the equity of the transport service. It is recommended to consider combining zonings of different sizes simultaneously, in order to accurately highlight imbalances and to argue for transport service improvements.
The Effect of Collective Electron‐Hole Plasma Modes on Charge Carrier Mobility in Polar Semiconductors

The dispersion relations for renormalized plasmon-phonon modes for PbTe and GaAs are calculated. Electron μe and hole μh mobilities are computed for scattering by these modes. It is found that with the increase of the charge carrier concentration, n, mobilities decrease due to the effect of dynamic antiscreening. In the concentration range where the free-carrier plasma frequency is comparable to the uncoupled LO-phonon frequency the mobilities reach minimum values. With further increase of n the antiscreening effect decreases and the mobilities begin to grow tending in the limit of high n to values corresponding to the quasistatic screening. [Russian Text Ignored].
Comparison of the Effectiveness of Four Different Crosslinking Agents with Hyaluronic Acid Hydrogel Films for Tissue-Culture Applications

Received 23 October 2006; accepted 13 December 2006DOI 10.1002/app.25993Published online 5 March 2007 in Wiley InterScience (www.interscience.wiley.com). ABSTRACT: The effectiveness of four different reagents,glutaraldehyde (GTA), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), poly(ethyelene glycol) diglycidylether (EX 810), and divinyl sulfone (DVS) as crosslinkersfor cast hyaluronic acid (HA) ﬁlms has been evaluated.Films were prepared by casting from solution and exposedto solutions of the crosslinkers in acetone–water solution.Swelling in water and in phosphate buffered saline (PBS)was then used to assess the effectiveness of the cross-linkers. GTA-crosslinked ﬁlms were found to be of lowstability compared with those treated with EDC, EX 810,and DVS. Results suggest that instability in GTA-cross-linked materials arises in part from residual acid catalyst.The effects of polymer molecular weight are not uniform.With GTA-crosslinked ﬁlm produced from higher molecu-lar weight HA swells more, and this is attributed toreduced diffusion of the crosslinker, but with EDC, theopposite effect is observed, implying some additional mo-lecular weight dependent mechanism. Differential scan-ning calorimetry and dynamic mechanical thermal analysisresults suggest that there are no signiﬁcant structural dif-ference between the gels for each crosslinker system andonly the crosslink density and moisture content alters thetransitions.
Effects of ‘Agri-SC’ soil conditioner on the erodibility of loamy sand soils in East Shropshire, UK: preliminary results

The effect of Agri-SC’ soil conditioner on the erodibility of loamy sand soils has been investigated at the Hilton experimental site, Shropshire, since March 1988. Factors measured have included runoff and erosion, soil structure, crust strength, splash susceptibility, aggregate stability, soil micromorphological properties, response to compaction and penetrometer resistance. Treatment decreased runoff and erosion rates, bulk density, splash erosion, crust strength and penetrometer resistance, and increased pore space and aggregate stability. The effects on crust strength, aggregate stability and bulk density were statistically significant. The results suggest that applications of ‘Agri-SC’ could have beneficial effects for soil conservation.
The Effect of Extraction Conditions on Total Phenolic Content and Free Radical Scavenging Capacity of Selected Tropical Fruits' Peel

The present study aimed to investigate the effects of ethanol concentration (0- 100%, v/v), extraction time (60-300 min), and extraction temperature (25-60°C) on total phenolic content (TPC) and free radical-scavenging capacity of rambutan (Nephelium lappaceum), mangosteen (Garcinia mangostana), and langsat (Lansium domesticum) peels using single-factor experiments. Folin-Ciocalteu's method was used for the determination of TPC, while the antioxidant capacity was determined by 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical- scavenging assay. All the extraction conditions showed significant effect (p<0.05) on TPC and DPPH radical-scavenging capacity. The best extraction conditions determined for rambutan peel were 80% ethanol concentration for 120 min at 50°C; for mangosteen peel were 60% ethanol concentration for 60 min at 25°C; and 80% ethanol concentration for 120 min at 25°C were the best extractions for langsat peel. Extracts were then subjected to various antioxidant assays such as DPPH assay, TPC, nitric oxide scavenging activity (NO) and β-carotene bleaching (BCB) assay. Based on these optimized extraction conditions, high antioxidant capacity was obtained with EC50 value of 8.87 µg/mL (DPPH radical scavenging activity), 64.88% for NO activity, and 98.19% for BCB activity; as well as 53.94 mg GAE/g (TPC) for rambutan peel. While mangosteen peel showed a EC50 value of 19.75 µg/mL (DPPH), 54.66% (NO), 79.94% (BCB), and TPC value of 42.25 mg GAE/g; and langsat peel with EC50 value of 85.28 µg/mL (DPPH), 50.42% (NO), 23.95% (BCB) and TPC value of 22.04 mg GAE/g. With these extraction
Are different volatile pattern influencing host plant choice of belowground living insects

Beeinflussen verschiedene Volatilenmuster die Wirtspflanzenwahl unterirdisch lebender Insekten? Zum besseren Verstandnis der Orientierung und Fraspraferenz von Maikaferlarven Melolontha hippocastani FABR. (Coleoptera: Scarabaeidae) im Boden wurden Wahltests durchgefuhrt. Den Larven von M. hippocastani wurden Karotten (Daucus carota ssp. sativus) und Eichenwurzeln (Quercus sp.) zur Auswahl angeboten. Die Duftstoffe von Karotte und Eichenwurzel wurden auf Aktivkohle gesammelt und mit Gaschromatographie - Massenspektroskopie untersucht (GC-MS). Unverletzte Karotten sowie Eichenwurzeln unterschieden sich in ihren Volatilenmustern deutlich voneinander. Daruber hinaus konnten Unterschiede im Volatilenmuster unverletzter, mechanisch verletzter sowie angefressener Wurzeln nachgewiesen werden.
Efﬁcient Partial-Pairs SimRank Search on Large Graphs

The assessment of node-to-node similarities based on graph topology arises in a myriad of applications, e.g., web search. SimRank is a notable measure of this type, with the intuition that “two nodes are similar if their in-neighbors are similar”. While most existing work retrieving SimRank only considers all-pairs SimRank s ( ⋆, ⋆ ) and single-source SimRank s ( ⋆, j ) (scores between every node and query j ), there are appealing applications for partial-pairs SimRank, e.g., similarity join. Given two node subsets A and B in a graph, partial-pairs SimRank assessment aims to retrieve only { s ( a, b ) } ∀ a ∈ A, ∀ b ∈ B . However, the best-known solution [18] is not self-contained since it hinges on the premise that the SimRank scores with node-pairs in an h -go cover set must be given beforehand. This paper focuses on eﬃcient assessment of partial-pairs SimRank in a self-contained manner. (1) We devise a novel “seed germination” model that computes partial-pairs Sim-Rank in O ( k | E | min {| A | , | B |} ) time and O ( | E | + k | V | ) memory for k iterations on a graph of | V | nodes and | E | edges. (2) We further prune redundant edge access to accelerate partial-pairs scores computation to O ( m min {| A | , | B |} ) time with m ≤ min { k | E | , d 2 k } , and d is the graph average degree. (3) We show two extra beneﬁts of our partial-pairs SimRank model: (a) Its special case improves the best-known single-source SimRank [10] from O ( d 2 k ) to O (min { k | E | , d 2 k } ) time. (b) It induces an O ( | E | + k | V | )-memory eﬃcient algorithm of all-pairs SimRank, unlike the best-known [14,16] that need O ( | V | 2 ) memory to store scores from the previous iteration. (4) We extend our methods to other measure, e.g., partial-pairs SimRank* [17] assessment. (5) We empirically verify that our algorithms are (a) 38x faster than the best-known competitors, and (b) memory-eﬃcient, allowing scores to be assessed accurately on graphs with tens of millions of links.
Recovery of low temperature electron irradiation-induced damage in n-type gaas

Abstract Undoped n-type GaAa was irradiated near 5 and 77 °K with electrons having incident energies between 0.46 and 1.30 MeV. The recovery of the electrical resistivity and the Hall coefficient upon annealing from 4 to 520 °K was monitored. Changes which occurred upon annealing below 200 °K could be reversed by ionizing radiation. A small amount of irreversible ionization-induced recovery was observed after irradiation near 5 °K. Major irreversible recovery stages were centered near 235 (stage I), 280 (stage II) and 520 °K (stage III). Recovery in stage I and II obeyed first order kinetics. The activation energies of stages I and II were determined as 0.72 and 0.83 eV, respectively. The carrier concentration changes per unit irradiation dose corresponding to the three recovery stages differed in their energy dependence indicating that the defects which are removed in stage III have the lowest threshold energy. The carrier concentration changes per unit irradiation dose corresponding to stages I and III .
PILOT SCALE PRODUCTION AND RELIABILITY TESTING OF SOLAR CELL MODULES BASED ON A LOW COST COPPER ELECTROPLATING PROCESS

As silicon solar cell technology featuring screen printed silver paste continues to mature, the cost of the front side conductor continues to grow as a percentage of the overall manufacturing cost. A cell concept based on electroplated nickel and copper contacts offers a significant cost savings, as well as a benefit to cell efficiency through reduced shading and lower contact and line resistance. This work details a new, simplified metallization process featuring pico-second laser ablation of the ARC combined with single-sided plating from a novel, high-speed copper formulation. More importantly, we present the details of a low cost scale-up of the metallization process on high volume mass production tools, plus fabrication of industrial modules and reliability testing according to IEC specifications. Electrical and adhesion data is presented on a statistically comprehensive sample set, proving the benefits of the new contact structure. These data offer the combined benefit of improved efficiency, a sizeable reduction in cell materials cost, and a clear pathway for the implementation of the process on a mass production scale.