Miracle-dz/UniFAR-FTUs huggingface dataset:
Methodology For Delivery and Kinetics of Clearance of Insoluble Particles from Sublobar Lung Segments

Anesthetized, mixed breed dogs were studied in a supine position, mechanically ventilated and imaged from the ventral aspect by γ-camera. Five dogs were evaluated; four of these were restudied to determine repeatability of the methods. A ventilation scan (133 Xe gas) was used to characterize the homogeneity of ventilation and to outline regions of analysis. An aqueous, insoluble radiolabeled aerosol (99m Tc-sulfur colloid) was generated by ultrasonic nebulization and delivered directly through a channel of a bronchoscope scope into sublobar bronchi. Lung retention of particles was measured continuously for ~ 1 h, followed by recovery; and dogs were reimaged at 6- and 24-h time points postdeposition. After the initial hour of clearance, mean particle retention tended to be lower in left lung segments as compared to the right lung segments, that is, 57.3% (±5.0% SE) and 75.4% (±6.7%), respectively; however, these differences were not significant. At the 6-h time postdeposition, clearance was more comparable between lung segments, that is, mean retention of 43.3% for the left versus 50.4% for the right lung segments. A small, additional amount of particle clearance occurred by the 24-h endpoint; the final mean retention levels were 34.8% and 47.1 % for respective left and right lung segments. This technique assesses mucociliary clearance of aqueous aerosols delivered directly to the epithelial surfaces of sublobar bronchi.
Arm Motor Recovery After Ischemic Stroke: A Focus on Clinically Distinct Trajectory Groups

Supplemental Digital Content is Available in the Text. Background and Purpose: Recovery of arm function poststroke is highly variable with some people experiencing rapid recovery but many experiencing slower or limited functional improvement. Current stroke prediction models provide some guidance for clinicians regarding expected motor outcomes poststroke but do not address recovery rates, complicating discharge planning. This study developed a novel approach to defining recovery groups based on arm motor recovery trajectories poststroke. In addition, between-group differences in baseline characteristics and therapy hours were explored. Methods: A retrospective cohort analysis was conducted where 40 participants with arm weakness were assessed 1 week, 6 weeks, 3 months, and 6 months after an ischemic stroke. Arm recovery trajectory groups were defined on the basis of timing of changes in the Fugl-Meyer Assessment Upper Extremity (FMA-UE), at least the minimal clinically important difference (MCID), 1 week to 6 weeks or 6 weeks to 6 months. Three recovery trajectory groups were defined: Fast (n = 19), Extended (n = 12), and Limited (n = 9). Between-group differences in baseline characteristics and therapy hours were assessed. Associations between baseline characteristics and group membership were also determined. Results: Three baseline characteristics were associated with trajectory group membership: FMA-UE, NIH Stroke Scale, and Barthel Index. The Fast Recovery group received the least therapy hours 6 weeks to 6 months. No differences in therapy hours were observed between Extended and Limited Recovery groups at any time points. Discussion and Conclusions: Three clinically relevant recovery trajectory groups were defined using the FMA-UE MCID. Baseline impairment, overall stroke severity, and dependence in activities of daily living were associated with group membership and therapy hours differed between groups. Stratifying individuals by recovery trajectory early poststroke could offer additional guidance to clinicians in discharge planning. (See Supplemental Digital Content 1 for Video Abstract, available at: http://links.lww.com/JNPT/A337.)
Theory of mind, executive function, and lying in children: a meta-analysis.

Scientific research on how children learn to tell lies has existed for more than a century. Earlier studies mainly focused on moral, social, and situational factors contributing to the development of lying. Researchers have only begun to explore the cognitive correlations of children's lying in the last two decades. Cognitive theories suggest that theory of mind (ToM) and executive function (EF) should be closely related to the development of lying since lying is, in essence, ToM and EF in action. Yet, findings from empirical studies are mixed. To address this issue, the current meta-analysis reviewed all prior literature that examined the relations between children's lying and ToM and/or between children's lying and EF. In total, 47 papers consisting of 5099 participants between 2 and 19 years of age were included, which yielded 74 effect sizes for ToM and 94 effect sizes for EF. Statistically significant but relatively small effects were found between children's lying and ToM (r = .17) and between lying and EF (r = .13). Furthermore, EF's correlation with children's initial lies was significantly smaller than its correlation with children's ability to maintain lies. This comprehensive meta-analysis provides a clear picture of the associations between children's ToM/EF and their lying behavior and confirms that ToM and EF indeed play a positive role in children's lying and its development.
Systemic immune-inflammation index: a prognostic tiebreaker among all in advanced pancreatic cancer

Background Pancreatic ductal adenocarcinoma (PDAC) detains a dismal prognosis and has a limited number of prognostic factors. Inflammation has been demonstrated to play a key role both in PDAC initiation and progression and several inflammation-based prognostic scores have been investigated in a wide range of malignancies. We compared the most analyzed inflammation-based prognostic scores in order to establish their potential impact on prediction of the outcome in advanced PDAC patients. Methods A total of 234 advanced PDAC patients undergoing first-line chemotherapy in our institute were retrospectively analyzed. Baseline clinicopathological and pre-treatment laboratory data were collected. Survival was estimated using Kaplan-Meier method and survival differences were evaluated using the log-rank test. Level of statistical significance P was set at 0.05. Only those variables that proved to be associated with statistically significant differences in outcome were compared in multivariate analysis using multiple Cox regression, as to identify their independent role and their relative power against each other. Results In the whole cohort, median overall survival (OS) was 8.7 months (95% CI: 7.8–9.4 months), median progression-free survival (PFS) was 3.8 months (95% CI: 3.1–4.2 months). At univariate analysis high systemic immune-inflammation index (SII) was related to shorter OS [hazard ratio (HR) =2.04, 95% CI: 1.59–4.19, P=0.0001] and PFS (HR =1.52, 95% CI: 1.11–2.20, P=0.01). This was maintained at multivariate analysis both for OS (HR =2.11, 95% CI: 1.29–3.46, P=0.003) and PFS (HR =1.64, 95% CI: 1.14–2.37, P=0.008), whereas other inflammation-based scores lost their independent role. Elevated SII (≥1,200) was associated with low albumin levels (P=0.03) and with elevated lactate dehydrogenase (LDH) (P=0.01). Conclusions Elevated SII represents an independent negative prognostic factor above all others for both OS and PFS in advanced PDAC patients treated with first-line chemotherapy, thus confirming a pivotal role of systemic inflammation on PDAC progression and on patient outcome.
Reliability and validity of a novel caregiver-assessed skills system based on the ALSO conception in children with autism spectrum disorders

Background In responding to the potential challenges in the transition from childhood to adulthood for individuals with autism spectrum disorders (ASD) in China, a novel conception of “ALSO” was proposed to bridge the transitional needs and early intervention. To facilitate the application of ALSO in early intervention, ALSOLIFE skills assessment system (ALSOLIFE Assessment) was developed to enable caregivers to evaluate their children’s skills guided by the ALSO conception. Given that the critical shortage of qualified professionals in China, many caregivers of children with ASD must function as home therapists. To address the practical needs of Chinese families of children with ASD, ALSOLIFE Assessment is designed as a free, online, technology-assisted, self-operated and behavioral intervention approaches supported system. The assessment report then further served as the basis for caregivers to deliver the tailored educational intervention to their children. Although ALSOLIFE Assessment provides caregivers a home-based intervention program, it is still unclear whether its evaluation is reliable and accurate. Therefore, we conduct this study to investigate the reliability and validity of the ALSOLIFE Assessment. Methods A total of 1,050 children with ASD (1 to 10 years old) were recruited from 31 provinces of mainland China. Their caregivers participated simultaneously as ALSOLIFE Assessment evaluators. The testing results of Verbal Behavior Milestones Assessment and Placement Program (VB-MAPP) and Psychoeducational Profile-3 (PEP-3) were also collected for a portion of the child participants (VB-MAPP, N=34; PEP-3, N=31) to check criterion-related validity. Results The reliability and validity of the ALSOLIFE Assessment satisfied psychometric requirements after the reduction from 511 to 464 items. Exploratory factor analysis (EFA) of ALSOLIFE Assessment scoring data yielded six factors, and confirmatory factor analysis (CFA) verified the best fitting construct model is a bifactorial model with one general factor and six group factors. Compared to the VB-MAPP and PEP-3, the ALSOLIFE Assessment exhibited good criterion-related validity across three levels: total scores, 6 skill domains, and 22 skill subdomains. The reliability tests indicated its strong internal consistency, test-retest reliability, and inter-rater reliability. Conclusions The reliability and validity of the revised ALSOLIFE Assessment (464-items) satisfied psychometric requirements. It is essential to develop validated and comprehensive evaluation tools, embedded on the needs of Chinese families of children with ASD.
Knowledge translation intervention increased the use of outcome measures by physical therapists in inpatient rehabilitation

ABSTRACT Background and Purpose Outcome measures (OMs) have been emphasized by healthcare professions to optimize patient examination; however, a lack of regular use of OMs exists. The purpose of this study was to describe the outcome of a knowledge translation (KT) intervention to increase the use of OMs by physical therapists in an inpatient rehabilitation setting. Methods A quasi-experimental pre-post study design was used. A multi-component KT intervention including education, organizational support, documentation, and environmental changes to increase the use of five OMs was implemented. Audit and feedback (A&F) was added to the KT intervention at month 6. Documented use of OMs was determined through manual chart audit (n = 864) and electronically (n = 2599). Regression analyses were used to identify factors associated with OMs use across time and diagnoses. Results Following the addition of A&F to the KT intervention at month 6, there was a significant increase in the odds of OMs use across all time intervals (months 6–12, 12–18, 18–24)(Odds Ratio (OR) 5.9, 95% Confidence Interval (CI) 4.1–8.5; OR 8.5, 95% CI 6.0–12.1; OR 10.8, 95% CI 7.6–15). There was also a significant increase in the odds of documenting OMs on individuals with neurological diagnoses (OR 0.3, 95% CI 0.5–0.8). Conclusions This KT intervention increased and sustained OMs use over 24-months. This intervention can be replicated to improve the evidence-based practices of physical therapists.
PySmash: Python package and individual executable program for representative substructure generation and application

BACKGROUND Substructure screening is widely applied to evaluate the molecular potency and ADMET properties of compounds in drug discovery pipelines, and it can also be used to interpret QSAR models for the design of new compounds with desirable physicochemical and biological properties. With the continuous accumulation of more experimental data, data-driven computational systems which can derive representative substructures from large chemical libraries attract more attention. Therefore, the development of an integrated and convenient tool to generate and implement representative substructures is urgently needed. RESULTS In this study, PySmash, a user-friendly and powerful tool to generate different types of representative substructures, was developed. The current version of PySmash provides both a Python package and an individual executable program, which achieves ease of operation and pipeline integration. Three types of substructure generation algorithms, including circular, path-based and functional group-based algorithms, are provided. Users can conveniently customize their own requirements for substructure size, accuracy and coverage, statistical significance and parallel computation during execution. Besides, PySmash provides the function for external data screening. CONCLUSION PySmash, a user-friendly and integrated tool for the automatic generation and implementation of representative substructures, is presented. Three screening examples, including toxicophore derivation, privileged motif detection and the integration of substructures with machine learning (ML) models, are provided to illustrate the utility of PySmash in safety profile evaluation, therapeutic activity exploration and molecular optimization, respectively. Its executable program and Python package are available at https://github.com/kotori-y/pySmash.
A randomized trial of an online, coach-assisted self-management PTSD intervention tailored for women veterans.

OBJECTIVE Scalable, efficiently delivered treatments are needed to address the needs of women Veterans with PTSD. This randomized clinical trial compared an online, coach-assisted cognitive behavioral intervention tailored for women Veterans with PTSD to phone monitoring only. METHOD Women Veterans who met diagnostic criteria for PTSD were randomized to an 8-week web-based intervention, called DElivery of Self TRaining and Education for Stressful Situations (DESTRESS)-Women Veterans version (WV), or to phone monitoring only (N = 102). DESTRESS-WV consisted of online sessions and 15-min weekly phone calls from a study coach. Phone monitoring included 15-min weekly phone calls from a study coach to offer general support. PTSD symptom severity (PTSD Symptom-Checklist-Version 5 [PCL-5]) was evaluated pre and posttreatment, and at 3 and 6 months posttreatment. RESULTS More participants completed phone monitoring than DESTRESS-WV (96% vs. 76%, p = 0.01), although treatment satisfaction was significantly greater in the DESTRESS-WV condition. We failed to confirm the superiority of DESTRESS-WV in intent-to-treat slope changes in PTSD symptom severity. Both treatments were associated with significant reductions in PTSD symptom severity over time. However, post hoc analyses of treatment completers and of those with baseline PCL ≥ 33 revealed that the DESTRESS-WV group had greater improvement in PTSD symptom severity relative to phone monitoring with significant differences at the 3-month follow-up assessment. CONCLUSIONS Both DESTRESS-WV and phone monitoring resulted in significant improvements in women Veterans' PTSD symptoms. DESTRESS-WV may be an appropriate care model for women Veterans who can engage in the demands of the treatment and have higher baseline symptoms. Future research should explore characteristics of and the methods of reliably identifying women Veterans who are most likely to benefit. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
Threadlike micelles from cetyltrimethylammonium bromide in aqueous sodium naphthalenesulfonate solutions studied by static and dynamic light scattering

Des mesures de diffusion de lumiere sont effectuees sur des solutions diluees et semi-diluees de micelles formees par des melanges equimolaires de naphtalenesulfonate de sodium et de bromure de cetyltrimethylammonium (CTAB)
QUALITY CURVES FOR MANGO FRUIT (CV. TOMMY ATKINS AND PALMER) STORED AT CHILLING AND NONCHILLING TEMPERATURES

"Tommy Atkins" and "Palmer" mangoes were harvested medium-ripe held for 7-20 days at five different temperatures and evaluated for quality attributes. The objective of this work was to obtain quality curves at chilling and nonchilling temperatures and to identify, for each temperature, which quality factors limit mango marketability. Chilling injury and increased fruit softness were the limiting quality factors for mango stored at 2 and 5C. Softening of the fruit, changes in color and development of decay were the limiting quality factors for mango stored at 12, 15 and 20C. Prediction of mango shelf life calculated from the data reported in the literature is not precise unless the characteristics of the fruit and environmental factors involved are well known. The curves obtained from quality evaluations for each temperature showed that a single quality attribute cannot be used to express loss of quality of mango over the normal physiological range of temperatures.
Analysis of Energy Consumption in Drying Process of Biomaterials Using a Combined Unsymmetrical Double-Feed Microwave and Vacuum System (CUMV)—Case Study: Tea Leaves

An energy analysis of drying of biomaterials (tea leaves) was conducted on a combined unsymmetrical double-feed microwave and vacuum system (CUMV) to optimize the operating conditions and quality of the products. Tea leaves were dried from an initial moisture content of 172 to 7% (db). An energy consumption model based on the first law of thermodynamics was developed to evaluate energy efficiency. The influences of microwave power, vacuum pressure, and microwave operation modes on energy consumption were investigated in detail. The results showed that energy consumption as well as energy efficiency were strongly dependent on vacuum pressure and microwave power. Energy consumption and color parameters of the tea leaves were compared at different drying conditions. In particular, the experiments were carried out at different microwave powers (800 and 1,600 W) at a frequency of 2,450 MHz and different vacuum pressures (535 and 385 torr) to investigate the effects of these factors on the microwave–vacuum drying.
Depression mediates the links between climacteric symptoms and food and nutritional insecurity

Abstract Objective This study is perhaps the first to evaluate the influence of depression on the relationship between climacteric symptoms and food and nutritional insecurity (FNI). Methods In this cross-sectional study with a relatively large sample of climacteric women (N = 400), sociodemographic and clinical variables were investigated. We measured FNI, depression and climacteric symptoms with psychometrically sound instruments, namely the Brazilian Food Security Scale, the Center for Epidemiologic Studies Depression Scale and the Kupperman Index, respectively. Results Statistically significant differences were observed in the means of FNI according to education, income, marital status, history of depression, use of antidepressants and current depression. Furthermore, depression had strong indirect effects on the relationship between climacteric symptoms and FNI. Conclusion Our study suggests that targeting depression could benefit climacteric women, especially those with severe symptoms and in FNI.
A Practical solution for aqueous reactions of water-insoluble high-melting-point organic substrates

A practical solution to the problem of performing aqueous reactions for very sparingly soluble high-melting-point (VSSHMP) organic substrates has been developed, which entails mechanically stirring a mixture of the substrate, the corresponding reagent(s), water, catalytic Aliquat 336 and sand. When the melting points of the substrates which include steroids, ketones, aldehydes, aromatics and alkaloids are around 200 °C, the reactions can be performed at 20 °C. The substrate solubility can be as low as 1 × 10−10 mol L−1.
Emission characteristics of printed carbon nanotube cathodes after laser treatment

Recently, field emission displays using printed carbon nanotubes (CNTs) as an emitter have been researched eagerly. By laser irradiation, some CNTs in the printed CNT layer stand out, and they work as the emission sites. We found that the higher CNTs that are easier to be the emission sites tend to exist at the boundary of the laser irradiation pattern. We used the irradiation patterns that consist of the arrays of microirradiation pattern to increase the total length of boundary. Both emission characteristics and emission uniformity were improved by the increase of the boundary length. We examined several lasers, and the irradiation by the second harmonic generation yttrium aluminum garnet laser of which wavelength was greatest in our experiment provided the best emission characteristics (turn-on electric field <2V∕μm) and emission uniformity (turn-on electric field deviation <5%).
The Effect of UK Nursing Policy on Higher Education Wound Care Provision and Practice: A Critical Discourse Analysis

In the United Kingdom, significant ongoing inconsistency exists in wound care nursing education provision and practice. Health economists have identified this to be a major cause of the burgeoning economic and personal cost of successfully, and equitably, healing chronic wounds. While numerous wound care educational resources exist, policies intended to implement a program of reform or change are for some reason not filtering down to, or being implemented by, those who need them most. Policy making processes do not appear to be operating as efficiently as they should, and this merits further scrutiny. A critical discourse analysis of two UK professional body wound care policies provided an innovative insight into the effect of policy production to the research problem. The overarching construct of “Aspiration and Resolution” and its subconstructs were identified. Links between data, analysis, and conclusions were established using Greckhamer and Cilesiz’s (2014) framework to address criticisms over lack of transparency in critical discourse analysis methodology. Findings indicate wound care policy makers must adopt an active, not passive, approach to policy making. An active position, compared with the inertia that appears to currently exist, would take into consideration the capacity to implement policy and not merely increase awareness or disseminate. Wound healing policy making agencies need to make decisions on how to disseminate and implement policy. Active policy making would also adopt target audiences’ decisions to implement policy, instigate activities to improve knowledge and skills, facilitate change, and ensure continued use of policy as part of organizational operations.