Miracle-dz/UniFAR-FTUs huggingface dataset:
Understanding Drivers of Resistance Toward Implementation of Web-Based Self-Management Tools in Routine Cancer Care Among Oncology Nurses: Cross-Sectional Survey Study

Background Supporting patients to engage in (Web-based) self-management tools is increasingly gaining importance, but the engagement of health care professionals is lagging behind. This can partly be explained by resistance among health care professionals. Objective The aim of this study was to investigate drivers of resistance among oncology nurses toward Web-based self-management tools in cancer care. Methods Drawing from previous research, combining clinical and marketing perspectives, and several variables and instruments, we developed the Resistance to Innovation model (RTI-model). The RTI-model distinguishes between passive and active resistance, which can be enhanced or reduced by functional drivers (incompatibility, complexity, lack of value, and risk) and psychological drivers (role ambiguity, social pressure from the institute, peers, and patients). Both types of drivers can be moderated by staff-, organization-, patient-, and environment-related factors. We executed a survey covering all components of the RTI-model on a cross-sectional sample of nurses working in oncology in the Netherlands. Structural equation modeling was used to test the full model, using a hierarchical approach. In total, 2500 nurses were approached, out of which 285 (11.40%) nurses responded. Results The goodness of fit statistic of the uncorrected base model of the RTI-model (n=239) was acceptable (χ21=9.2; Comparative Fit Index=0.95; Tucker Lewis index=0.21; Root Mean Square Error of Approximation=0.19; Standardized Root Mean Square=0.016). In line with the RTI-model, we found that both passive and active resistance among oncology nurses toward (Web-based) self-management tools were driven by both functional and psychological drivers. Passive resistance toward Web-based self-management tools was enhanced by complexity, lack of value, and role ambiguity, and it was reduced by institutional social pressure. Active resistance was enhanced by complexity, lack of value, and social pressure from peers, and it was reduced by social pressure from the institute and patients. In contrast to what we expected, incompatibility with current routines was not a significant driver of either passive or active resistance. This study further showed that these drivers of resistance were moderated by expertise (P=.03), managerial support (P=.004), and influence from external stakeholders (government; P=.04). Conclusions Both passive and active resistance in oncology nurses toward Web-based self-management tools for patients with cancer are driven by functional and psychological drivers, which may be more or less strong, depending on expertise, managerial support, and governmental influence.
Identification and validation of potential targets for the diagnosis and therapy of chronic lymphocytic leukaemia

Treatment of chronic lymphocytic leukaemia (CLL) has greatly improved with the use of combination chemo-immunotherapy but the treatment of relapsed and fludarabine refractory CLL is still challenging with the current agents. Large amounts of mRNA expression data are publicly available but identifying suitable targets requires validation at the protein level. I used available RNA expression data to identify candidate antigens that could be screened for protein level expression using commercially available monoclonal/polyclonal antibodies. To test new molecules I optimised an in-vitro viability assay system using mononuclear cells and standard viability assessments. To study pathway interactions, B-cell receptor (BCR) was stimulated using goat F(ab’)2 anti-human IgM or IgD and signalling responses were assessed by SYK-phosphorylation (SYK pY348PE) and calcium-flux measured by ratiometric difference in florescent intensity of Fluo-3/Fura-red. I assessed 84 antigens and 15 showed binding on CLL cells and/or normal B-cells but not other leucocytes. I found that 7 of the 15 molecules have a recognised role in neurotransmission, such as the nicotinic acetyl choline receptor subunit β4 and dopamine receptor D4. This observation indicated that these molecules and pathways were potentially involved in the pathophysiology of CLL and I therefore further investigated their importance. In exploring the newly identified targets, I found that dopamine and D2 antagonist domperidone reduced CLL cell survival in vitro, in a dose dependent manner. While elucidating the downstream mechanisms for the above effect, I observed that dopamine significantly reduced SYK phosphorylation and calcium flux induced by stimulation of the BCR pathway using goat F(ab’)2 anti-human IgD. In vitro testing also demonstrated a synergistic effect in blocking of the D2 and the BCR pathways as a combination of PI3-kinase δ inhibitor (GS-1101) with domperidone reduced CLL cell viability more efficiently than either agent alone. Therefore I have identified a number of novel molecules expressed in CLL and further investigated their biological importance in the disease pathophysiology. These novel molecules provide several potential untested therapeutic targets in CLL.
Effect of oral administration of silver nanoparticles on blood parameters and bone marrow cells of female albino rats

Background: The aim of this study was to investigate the effect of oral acute dosing with silver nanoparticles (AgNPs) and identify potential genotoxicity and their effect on blood parameters in the female albino rat. Methods: Eighteen female rats were used to assess the acute effects of AgNPs. Rats in the treatment group were gavaged with 1 mL of di-ionized water containing AgNPs at dose of 1/50 and 1/100 of LD50 weight on 6th to 15th day of gestation of pregnant female albino rats. Control rats received 1 mL of di-ionized water only. After 20 days of gestation, rats were euthanized, blood samples and bone marrow were collected to investigate for hematologic and genotoxicity of sliver nanoparticles. Results and conclusion: AgNPs were enhanced hematotoxiciy in female albino rats at time of delivery and after end of treatment evidenced by reduced level of RBC, WBC, hemoglobin and calculated hemo-indices. Notably, AgNPs enhanced genotoxicity by increased chromosomal aberrations at dose dependent manner. While no change in micronuclei numbers when compared to control group. Taken collectively, AgNPs considered not safe as pharmacological agent during pregnancy.
Screening of core genes and pathways in breast cancer development via comprehensive analysis of multi gene expression datasets

Breast cancer has been the leading cause of cancer-associated mortality in women worldwide. Perturbation of oncogene and tumor suppressor gene expression is generally considered as the fundamental cause of cancer initiation and progression. In the present study, three gene expression datasets containing information of breast cancer and adjacent normal tissues that were detected using traditional gene microarrays were downloaded and batch effects were removed with R programming software. The differentially expressed genes between breast cancer and normal tissue groups were closely associated with cancer development pathways. Interestingly, five pathways, including ‘extracellular matrix-receptor interaction’, ‘peroxisome proliferator-activated receptors signaling pathway’, ‘propanoate metabolism’, ‘pyruvate metabolism’ and ‘regulation of lipolysis in adipocytes’, were thoroughly connected by 10 genes. Patients with upregulation of six of these hub genes (acetyl-CoA carboxylase β, acyl-CoA dehydrogenase medium chain, adiponectin, C1Q and collagen domain containing, acyl-CoA synthetase short chain family member 2, phosphoenolpyruvate carboxykinase 1 and perilipin 1) exhibited improved breast cancer prognosis. Additionally, breast cancer-specific network analysis identified several gene-gene interaction modules. These gene clusters had strong interactions according to the scoring in the whole network, which may be important to the development of breast cancer. In conclusion, the present study may improve the understanding of the mechanisms of breast cancer and provide several valuable prognosis and treatment signatures.
The Application of High Intensity Interval Training (HIIT) Method to the Increase of Aerobic Ability of Female Futsal Players

Physical training is one of some important and decided factor in reaching the achievement. There are some method of training that can be used in increasing the abilities of physic. Futsal is the sport which need the prime physical ability. One of some components of futsal player physical ability as the beginning fundamental; is the endure (aerobik). The purpose of this research is in order to know the meaningful of the influence of HIIT training method application to the increasing of ability of aerobik. Population in this research is the unit of activity of female Indonesia Education University student for futsal is about 26 persons and sample that be taken is about 14 persons who be chosen as the needs of team. Sampling technical use purposive sampling technical. Research method use experiment method. Data collecting use bleep test for measuring the endure or aerobic of body. The statistic calculation use two average equivalent test. The result of research point out the average value of beginning test (X̅) is about 41,0 by deviation standard (S) is about 6.4 and final test average value (X̅) is about 43,5 by deviation standard (S) is about 3,50. Analysis result and data calculation tell whereas there is a significant influence for HIIT training method to the increasing of ability of aerobik. Keywords—HIIT method; aerobic ability; bleep test
Tailoring digital apps to support active ageing in a low income community

Despite physical activity being one of the determinants of healthy aging, older people tend to become less active over the years. Maintaining physical activity levels during the life course is a motivational challenge. Digital tools have been used to change this pattern, such as smartphone applications to support physical activity; but there is a lack of in-depth research on the diversity of user’s experiences, especially considering older users or non-users of information and communication technologies. Objective: Our goal was to identify requirements for designing a mobile app to encourage physical activity in a low-income community population of older people in Brazil (i.e. over 40 years old). Method: We conducted a qualitative focus group study, involving by co-design of a physical activity application (Pacer)®. Seventeen volunteers were divided into 2 focus groups of physical active and insufficiently active, and 2 further 4 subgroups in each characterised by digital engagement. The following procedures were performed: (i) baseline assessments; (ii) a focus group with physically active older people and a focus group with insufficiently active older people (iii) design activities with both groups to re-design Pacer. Results: Developing physical activity apps for older people should consider the following features: free application, simple interface, motivational messages using audio and visual information, sharing information among users, multimedia input and sharing and user customisation. In particular, we recommend that exercise apps in low-income communities be tailored to our four categories of users differing in baseline physical activity and digital engagement, to match the social and behavioural preferences we discovered.
Community-Based AIDS Prevention: Preliminary Outcomes of a Program for African American and Latino Injection Drug Users

This paper presents preliminary outcomes of a community-based AIDS prevention program for drug users called Project COPE II, the National Institute on Drug Abuse (NIDA) cooperative agreement study in Hartford, Connecticut. COPE II's efficacy study compares the NIDA standard intervention against two culturally targeted, enhanced interventions, one for African Americans and one for Puerto Ricans. A sample of 188 out-of-treatment injection drug users (IDUs) with matched baseline and 6-month follow-up interviews were compared for changes in monthly injection rates and proportionate use of new and pre-used needles and used injection supplies. Effects of injection outliers, attrition, and ethnic differences were examined for impact on outcome measures and to identify subgroups within the study population for whom the intervention had differential effects. These preliminary analyses suggest that attendance in culturally targeted enhanced interventions may increase the likelihood of positive program outcome, including drug-related risk reduction for some populations. However, subgroups of IDUs, such as extremely high injectors or individuals who drop out before initiating or completing the program, may require different intervention approaches. Further research is needed to understand the relationship between intervention and behavior change, reasons for attrition, and moderating factors affecting project outcomes.
Research on Bit Error Rate Measurement and Evaluation for SpaceWire Bus

This paper designs some test boards and systems based on the aerospace application requirements and the characteristics of SpaceWire devices. A communication bit error rate measurement method for SpaceWire bus is proposed. And the signal quality of SpaceWire bus is evaluated according to the experimental data and eye diagrams. The results show that SpaceWire devices and systems meet requirements of space environments and they are of high reliability for Spacecraft communication systems. The BER test method based on the complex connection structure of SpaceWire bus has 99% confidence, which can shorten the test time to 16 hours.
Recruiting Volunteers to Teach a Community-Based Wellness Program: Seniors CAN. 1

This report surveys the literature available on volunteers, particularly older volunteers, examines how the desire for lifelong learning may encourage volunteers, and discusses the connection between volunteering and well-being. It identifies volunteers from two groups: peer-educators from the target audience over 55 years of age; and the staff of agencies that already provide services to elderly clients, such as assisted living facilities or low-income housing agencies that want to add wellness education instruction. Then the report identifies locations to find potential volunteer older adult peer-educators; recommends proposals for recruiting such volunteers as well as paid staff of social service agencies to teach the program; and outlines steps to take in such a recruitment.
10. Time and frequency domain analysis of heart rate variability after myocardial infarction

Despite the significant reduction in mortality which has been obtained over the last few years, the identification of patients at risk after a myocardial infarction remains one of the most important objectives for clinical cardiol­ ogy. In addition to the more traditional techniques based upon the evaluation of residual left ventricular dysfunction or ischemia and upon the characteriz­ ation of cardiac electrical instability, as indicated by the presence of ventricu­ lar arrhythmias or ventricular late potentials, new approaches have been recently proposed to evaluate the alterations of neural regulatory mechanisms and to identify patients at risk. Among them, the study of heart rate vari­ ability has provided the most relevant clinical results. In patients after acute myocardial infarction, Kleiger et a1. [1] observed that a decreased heart rate variability was associated with increased mortality. In particular, these authors reported that patients who at the time of dis­ charge had a standard deviation of the 24-h Holter recording of less than 50 ms exhibited a relative risk of mortality 5.3 times higher than that of patients with a standard deviation greater than 100 ms. A reduced heart rate variability remained a significant predictor of mortality after adjusting for clinical. demographic and Holter features , and ejection fraction. To explain their findings, Kleiger et a1. [1] advanced the hypothesis that a decreased heart rate variability correlated with an increased sympathetic or decreased vagal tone , which could predispose to ventricular fibrillation. In the same year we published an article [2] about a smaller group of patients whose RR interval variability during lO-min controlled resting conditions was analyzed with spectral techniques 2 weeks, 6 and 12 months after an acute myocardial infarction. In comparison to an age-matched con­ trol group, patients 2 weeks after myocardial infarction presented with a significant increase in the low-frequency (LF) and a marked decrease of the high-frequency (HF) component of RR variability that were consistent with a shift of sympathovagal balance towards sympathetic predominance. The
The use of serial cardiac 18F-fluorodeoxyglucose– positron emission tomography imaging to diagnose, monitor, and tailor treatment of cardiac sarcoidosis patients with arrhythmias: a case series and review

Abstract Background Clinically evident cardiac involvement has been documented in 5% of sarcoidosis patients, primarily manifesting as heart block, ventricular arrhythmias, and heart failure. Heart Rhythm Society consensus guidelines recommend advanced cardiac imaging with fluorodeoxyglucose–positron emission tomography (FDG-PET) scan for diagnosis of cardiac sarcoidosis, given endomyocardial biopsy’s low sensitivity. Case summary We describe four patients with cardiac sarcoidosis diagnosed with FDG-PET scan performed using a standardized imaging protocol for cardiac sarcoidosis. Serial FDG-PET scans were performed to monitor disease progression and response to therapy. Patients 1 and 2 presented with heart block, Patient 3 with heart failure and ventricular tachycardia (VT), and Patient 4 with VT. Patient 1 showed an initial decrease in standard uptake value (SUV) on immunosuppression, followed by an increase in SUV, necessitating steroid therapy. Patient 2’s SUV decreased on immunosuppression. Patient 3 required 3.5 years of immunosuppression for the SUV to decrease to inactive disease levels, with SUV increasing and decreasing at different times during treatment, and subsequently developed VT. For Patient 4, areas of inflammation on the initial scan matched low voltage areas on the patient’s EP study, confirming the arrhythmia’s pathophysiological basis. Discussion Cardiac sarcoidosis progression and response to therapy are heterogeneous. Serial FDG-PET scans are useful to diagnose disease, tailor therapy, and monitor the clinical course of disease, allowing treatment decisions to be based on the quantitative level of inflammation seen on FDG-PET.
Intravital microscopy reveals complete regression of large, established CNS lymphoma after intracerebral CAR T cell injection

Primary CNS lymphoma (PCNSL) is a highly malignant brain tumor. To assess the therapeutic effect of chimeric antigen receptor (CAR) T cells on PCNSL, we established a novel mouse model allowing for repeated in vivo two photon microscopy of orthotopic PCNSL growth. Hereby, we assessed the therapeutic efficacy as well as the intratumoral behavior of CAR T cells. Our data illustrate the great potential of CAR T cells in the treatment of PCNSL.
In-Band Controllable Radio Interference Generation for Wireless Sensor Networks

Interference signals negatively impact the performance of wireless embedded systems. The increased packet losses, delays, and energy consumption experienced by devices operating in environments subject to interference are particularly critical in constrained systems such as wireless sensor networks. The need to design and test systems for mitigating the effects of interference prompts for the capability of reproducing in a controllable way suitable interference signals. Solutions have been proposed recently, which tackle the problem by making use of 802.15. 4 compliant radio transceivers, like those available on board of commonly used sensor nodes, thus paving the way for low cost and repeatable generation of interference which could reliably emulate real-world scenarios, for instance densely deployed networks. In this paper, we present an investigation regarding the emulation of interference sources by means of 802.15. 4 radios on novel 32-bit wireless system-on-chip. The study is based on an extensive experimental evaluation, providing novel insights into the main features of the system. In particular, the effects of interference on the communication link, measured in terms of packet reception rate, are investigated for different parameters (namely, duty cycle and power of the interference signal, communication protocols, and payload size), and results are discussed concerning the feasibility of emulating background noise by means of the analyzed techniques.
Functional level assessment of individuals with transtibial limb loss: Evaluation in the clinical setting versus objective community ambulatory activity

The functional level (K level) of prosthetic users is used to choose appropriate prosthetic components, but ratings may highly subjective. A more objective and robust method to determine K level may be appealing. The aim of this study was to determine the relationship between K level determined in the clinic to K level based on real world ambulatory activity data collected by StepWatch. Twelve individuals with transtibial limb loss gave informed consent to participate. K level assessments performed in the clinic by a single treating prosthetist were compared with a calculated estimate based on seven days of real world ambulatory activity patterns using linear regression. There was good agreement between the two methods of determining K level with R2 = 0.775 (p < 0.001). The calculated estimate of K level based on actual ambulatory activity in real world settings appears to be similar to the treating prosthetist’s assessment of K level based on gait observation and patient responses in the clinic. Clinic-based ambulatory capacity in transtibial prosthetic users appears to correlate with real world ambulatory behavior in this small cohort. Determining functional level based on real world ambulatory activity may supplement clinic-based tests of functional capacity.
Mathematical Models of Cancer Cell Plasticity

Quantitative modelling is increasingly important in cancer research, helping to integrate myriad diverse experimental data into coherent pictures of the disease and able to discriminate between competing hypotheses or suggest specific experimental lines of enquiry and new approaches to therapy. Here, we review a diverse set of mathematical models of cancer cell plasticity (a process in which, through genetic and epigenetic changes, cancer cells survive in hostile environments and migrate to more favourable environments, respectively), tumour growth, and invasion. Quantitative models can help to elucidate the complex biological mechanisms of cancer cell plasticity. In this review, we discuss models of plasticity, tumour progression, and metastasis under three broadly conceived mathematical modelling techniques: discrete, continuum, and hybrid, each with advantages and disadvantages. An emerging theme from the predictions of many of these models is that cell escape from the tumour microenvironment (TME) is encouraged by a combination of physiological stress locally (e.g., hypoxia), external stresses (e.g., the presence of immune cells), and interactions with the extracellular matrix. We also discuss the value of mathematical modelling for understanding cancer more generally.