Miracle-dz/UniFAR-FTUs huggingface dataset:
Complete plastome sequence of Paeonia lactiflora Pall. (Paeoniaceae: Saxifragales)

Abstract Paeonia lactiflora has been listed as an Endangered species in Russian Federation. The complete plastome was assembled from Next-Generation Sequencing data. It is 152,747 bp in length. It consists of a pair of Inverted Repeat regions (25,651 bp), separated by a small single copy region of 17,033 bp and a large single copy region of 84,412 bp. The plastome encoded 128 genes, including 83 protein coding genes, 37 tRNA, eight rRNA genes, four pseudogenes, and is characterized by loss of the rpl32 and infA genes. Phylogenetic analysis of Paeoniaceae plastomes revealed that P. lactiflora clustered with Eurasian peonies (section Paeoniae).
Synthesis of MnII and CuII complexes including azobenzene and its application to mediators of laccase for biofuel cells

Laccase is mainly used as an enzyme of a cathode electrode of a biofuel cell. One problem is rate limiting of electron transfer between electrodes and enzymes. To enhance transfer of electron from the electrode to the redox center in the enzyme, using mediators instead of substrates of laccase is one the solution. A selection of the mediator is important in improving the performance of the biofuel cell. Our laboratory has succeeded in improving the electron transfer function by controlling the polarization-induced molecular orientation of a complex having an azo dye in a laccase matrix. In this study, we will synthesize a mononuclear complex including azobenzene, a binuclear complex and a tetranuclear complex containing Cu II or Mn II/III ions, and evaluate how much multistep electron transfer and molecular orientation by multinuclear complex will contribute to function as a mediator.
A comparison of the ZnS(Ag) scintillation detector to the silicon semiconductor detector for quantification of alpha radioactivity in aqueous solutions

A ZnS(Ag) detector was successfully used in the direct detection of alpha particles from aqueous solutions and the results were compared to the passivated ion implanted planar silicon (PIPS) continuous air monitor (CAM) detector. The ZnS(Ag) detector is recommended for on-line detection of gross alpha radioactivity from highlevel liquid waste process streams; however, the detector suffers from limitations due to variations in detection efficiency with alpha energies. The beta and gamma interference did not significantly spillover into the alpha region of interest of the ZnS(Ag) detector which provided absolute detection efficiencies of 7.19 + 0.13%, 5.37 + 0.02%, and 4.21 + 0.03% for Cm, Pu, and U/U solutions, respectively. The detection efficiencies were found with a 3.5 mg/cm ZnS(Ag) scintillation layer, 4.15 cm detection surface, and a 5.2 mm air gap between the liquid surface and the detector. The absolute detection efficiencies of the PIPS CAM detector for Cm, Am, Pu, and Th solutions in the presence of beta and gamma activity were 4.61 + 0.01%, 3.87 + 0.01%, 2.84 + 0.01%, and 1.32 + 0.01%, respectively, for a geometrical set-up similar to the ZnS(Ag) experiments. Two ZnS(Ag) scintillator thicknesses were compared. The thicker scintillation layer suffered from light absorption and scattering in the ZnS(Ag) layer resulting in a lower energy signal. Despite the differences, the absolute detection efficiencies of the two thicknesses were equivalent. The large detection area available to the ZnS(Ag) detector proved to be valuable for the detection of radioactivity in liquids as the absolute detection efficiency more than doubled for a surface area of 78.5 cm and resulted in a minimum detection concentration of 0.32 Bq/mL for U solution for a 3600 second count. The detection capabilities and pulse height spectra of the ZnS(Ag) detector were compared to the PIPS CAM detector as well as computer simulations and theory. iii
Setting time, compressive strength and sulfuric acid resistance of a high calcium fly ash geopolymer containing borax

The objective of this research was to study the influence of borax on setting time and other properties viz., workability, compressive strength and sulfuric acid resistance of a high calcium fly ash (HCFA) geopolymer. Four borax types viz., deca‑hydrate borax, deca-hydrate borax heat‑treated for 5-minutes and 10-minutes and anhydrous borax were used to replace fly ash. A liquid to binder ratio (L/B) of 0.60, a 10M NaOH solution, and Na2SiO3/NaOH at a ratio of 1.0 were used in the formulation of the geopolymer. The results indicated that the replacement of fly ash with borax accelerated the initial setting time but retarded the final setting time of the geopolymer paste. The flow of mortar with deca-hydrate borax remained unaffected by the increase in the amount of borax. For other borax types, the mortar flow was reduced and this was related to the water molecules in the borax. The compressive strength of the mortar tended to decrease with increasing borax content. The resistance of the mortar to 3% sulfuric acid was reduced with increased borax content. The use of borax should be around 2.5% to control the setting of a high calcium fly ash geopolymer and to obtain good strength and resistance to acid.
Clinical Evidence for the Importance of 1-Carbon Cycle Support in Subfertile Couples

This study assesses the effect of nutritional support directed towards the 1-C cycle on the fertility of male and female patients attending an ART program. In a first group, female partners of couples having failed at least one ART attempt were administered 1-C nutritional support prior to a further ART cycle. A second group comprised couples who had failed at least 2 assisted reproductive technology (ART) attempts, with male partners having elevated DNA fragmentation index (DFI) or nuclear decondensation index (SDI). The treatment consisted of compounds that play a major role in the 1-C cycle: B vitamins, chelated zinc and N-acetyl cysteine. The first group of 100 treated female patients achieved a clinical pregnancy rate (PR) of 45%, with a high rate of spontaneous conception before ART. This was significantly higher (p=0.0001) than the PR observed in the control group of 73 patients, with PR =13.7%. When the male partners alone (95) were treated, a significant decrease was observed for DFI and SDI vs. control (84), and this was associated with a significant increase in the delivery rates (47.4% vs. 21.4%, p=0.001). Nutritional support of the 1-C cycle improves male and female fertility; this should not be overlooked, especially for women entering ART programs. between oxidative stress and methylation processes 1- Correct recycling of Homocysteine allows generation of Cysteine and methionine which allows correct processes of methylation (1bis). 2- Correct generation of cysteine allows synthesis of Hypotaurine and glutathione, two potent inhibitors of ROS. 3- Generation of ROS induces DNA fragmentation. Advanced age decreases the ability to control ROS-linked decays. 4-High levels of homocysteine inhibit methylation processes in sperm physiology (methylation of the membrane lipids) and in sperm DNA. 5 - DNA methylation defects, whether or not linked to imprinting may result in negative transgenerational health problems. Unrepaired 8 oxoG leads to aberrant methylation at CpG sites, impair transcription and may affect telomere length. 6- Plastics Derived Endocrine Disruptors (BPA, DEHP and DBP) worsen all the negative steps.
Vehicular impact as a source of wildlife mortality in the Western Pacific Coast of Mexico

Road construction produce abrupt changes in landscape topography, microclimate, vegetation cover and levels of traffic noise. Moreover, road networks negatively affect vertebrate abundance, population gene flow, animal behavior and individual survival. Between July 2010 and January 2011, we conducted 10 surveys of animals killed on a road in Michoacan, Mexico. We recorded a total of 314 animals killed which included: 15 species of reptiles, 13 of mammals, 9 of birds, and 1 amphibian. Mammals were the most impacted accounting for 65% of the road kills followed by reptiles (25%). Mortality concentrated on road sections combining low sinuosity with high forest cover. Of the 15 reptile species recorded, 6 were endemic and 10 were listed as globally threatened or subject to special protection in Mexico. Road killed mammals also included species of conservation concern, 3 of which were endemic to Mexico. Our findings confirm that roads are a major mortality source for wild fauna. Strategies are greatly needed, at the global and local level, to mitigate the impact of roads on biodiversity.
Risk factors of esophageal stenosis after endoscopic submucosal dissection with 1/2-3/4 circumferential mucosal defect

Objective To analyze the incidence and risk factors of postoperative esophageal stenosis after endoscopic submucosal dissection (ESD) with mucosal defect of 1/2-<3/4 circumference. Methods A retrospective analysis was performed on the data of 301 patients with early esophageal cancer or precancerous lesions undergoing ESD at Drum Tower Hospital between January 2013 and August 2015. The incidence and risk factors for postoperative stenosis were analyzed. Results Esophageal stenosis was observed in 13 cases among the 113 cases of 1/2- 0.05), while the rate of lesions in the upper esophagus in stenosis group was higher than that in the control group (P<0.05). Conclusion Mucosal defect of 1/2-<3/4 circumference has a lower esophageal stenosis rate after ESD, which is related to the location of lesion. The ratio of upper esophagus lesion in the stenosis group is significantly higher than that in the non-stenosis group. Key words: Esophageal neoplasms, early stage; Endoscopic submucosal dissection; Esophageal stenosis, postoperative; Risk factors
La solución de optimización C2NET

Today’s lack of competitiveness of European enterprises has led to the Cloud Collaborative Manufacturing Networks (C2NET) European funded project to develop an optimisation solution to provide enterprises, particularly small- and medium sized ones (SMEs), affordable and easy-to-use means to optimise their planning activities to improve their efficiency and competitiveness. This paper focuses on the C2NET optimisation solu-tion, constituted mainly by C2NET Optimiser module components: (i) optimisation algorithms; (ii) the solver manager; (iii) the optimisation problem configurator; (iv) processes of the optimisation of manufacturing assets manager. To perform optimisation, it is necessary to provide the previous components with the needed input data, which can be done within the data collection framework module by defining a standardised data model (STables). Another data model is defined to show optimisation results to SMEs, namely the plan data model (PTables). The C2NET Optimisation Solution supports manufacturing networks, especially those composed of SMEs, and is based on the optimisation of manufacturing and logistics assets by the single and/or collaborative computation of production, replenishment and delivery plans.
Assessing the Impact of Cyclosporin A on Lentiviral Transduction and Preservation of Human Hematopoietic Stem Cells in Clinically Relevant Ex Vivo Gene Therapy Settings

Improving hematopoietic stem and progenitor cell (HSPC) permissiveness to lentiviral vector (LV) transduction without compromising their biological properties remains critical for broad-range implementation of gene therapy as a treatment option for several inherited diseases. This study demonstrates that the use of one-hit ex vivo LV transduction protocols based on either cyclosporin A (CsA) or rapamycin enable as efficient gene transfer as the current two-hit clinical standard into bone marrow–derived CD34+ cells while better preserving their engraftment capacity in vivo. CsA was additive with another enhancer of transduction, prostaglandin E2, suggesting that tailored enhancer combinations may be applied to overcome multiple blocks to transduction simultaneously in HSPC. Interestingly, besides enhancing LV transduction, CsA also significantly reduced HSPC proliferation, preserving the quiescent G0 fraction and the more primitive multipotent progenitors, thereby yielding the highest engraftment levels in vivo. Importantly, no alterations in the vector integration profiles could be detected between CsA and control transduced HSPC. Overall, the present findings contribute to the development of more efficient and sustainable LV gene therapy protocols, underscoring the benefits of scaling down required vector doses, as well as shortening the HSPC ex vivo culture time.
Generalized Structured Component Analysis in candidate gene association studies: applications and limitations

Background: Generalized Structured Component Analysis (GSCA) is a component-based alternative to traditional covariance-based structural equation modelling. This method has previously been applied to test for association between candidate genes and clinical phenotypes, contrasting with traditional genetic association analyses that adopt univariate testing of many individual single nucleotide polymorphisms (SNPs) with correction for multiple testing. Methods: We first evaluate the ability of the GSCA method to replicate two previous findings from a genetics association study of developmental language disorders. We then present the results of a simulation study to test the validity of the GSCA method under more restrictive data conditions, using smaller sample sizes and larger numbers of SNPs than have previously been investigated. Finally, we compare GSCA performance against univariate association analysis conducted using PLINK v1.9. Results: Results from simulations show that power to detect effects depends not just on sample size, but also on the ratio of SNPs with effect to number of SNPs tested within a gene. Inclusion of many SNPs in a model dilutes true effects. Conclusions: We propose that GSCA is a useful method for replication studies, when candidate SNPs have been identified, but should not be used for exploratory analysis.
A Study on Detection of Soybean Oil and Buffalo Depot Fat in Ghee Using Normal-Phase Thin Layer Chromatography

A study was carried out to detect soybean oil and buffalo depot fat, when adulterated individually in cow and buffalo ghee @5, 10, 15% (v/v) respectively, by using normal phase thin layer chromatography (TLC). Unsaponifiable matter (USM) of all the samples were extracted by using diethyl ether after saponification with alcoholic potassium hydroxide and were made alkali free by washing with water, followed by drying and dissolving in chloroform. Spotting of USM from all the samples was done on TLC plates, along with some reference standards of sterols (cholesterol, cholesterol acetate, β-carotene, phytosterols and tocopherols) and the plates were developed by using suitable solvent system ( cyclohexane: ethyl acetate: water::600:200:1, v/v) . It was observed from the results that soybean oil was easily detected even at the level of 5%, in both types of the ghee studied, by getting three extra spots or bands (R f values 0.465, 0.512, 0.557) in the reference area as compared to pure samples, while buffalo depot fat didn’t show any additional marks in comparison to pure samples of cow and buffalo ghee.
The Human Dimension of Open Innovation: Structured Literature Review

The concept of open innovation was first introduced in 2003 by Henry Chesbrough. Research on this topic has been pursued, observing the subject from different angles and integrating it into different scientific fields. However, the “human side” of open innovation is still understudied; hence, there is a need to link open innovation with HRM. The aim of this paper is then to find out what has already been done in this field (the contributions of the various studies undertaken) and what remains to be achieved (perspectives for future research). To do this, a structured literature review on the subject was conducted.
A Survey on Ethereum Systems Security

Blockchain technology is believed by many to be a game changer in many application domains. While the first generation of blockchain technology (i.e., Blockchain 1.0) is almost exclusively used for cryptocurrency, the second generation (i.e., Blockchain 2.0), as represented by Ethereum, is an open and decentralized platform enabling a new paradigm of computing—Decentralized Applications (DApps) running on top of blockchains. The rich applications and semantics of DApps inevitably introduce many security vulnerabilities, which have no counterparts in pure cryptocurrency systems like Bitcoin. Since Ethereum is a new, yet complex, system, it is imperative to have a systematic and comprehensive understanding on its security from a holistic perspective, which was previously unavailable in the literature. To the best of our knowledge, the present survey, which can also be used as a tutorial, fills this void. We systematize three aspects of Ethereum systems security: vulnerabilities, attacks, and defenses. We draw insights into vulnerability root causes, attack consequences, and defense capabilities, which shed light on future research directions.
Design of a Novel Elastic Torque Sensor for Hand Injuries Rehabilitation Based on Bowden Cable

Rehabilitation of the hands is critical to the recovery of functions in daily life for individuals with hand injuries. It is documented that robots with force control can help patients effectively in limb rehabilitation. However, considering the limited space of the hands, traditional torque sensors, strain beams, for example, cannot meet the need of the compact structure. Therefore, this paper presents a novel elastic torque sensor with a compact structure to realize the real-time measurement of joint torque for hand rehabilitation. We demonstrate the principle of the torque sensor by analyzing the relationship between the angle and the torque of the joint. Integrated in the exoskeleton, the torque sensor is designed with a compact structure based on the Bowden cable. Finally, we carried out experiments to show the good linearity and torque tracking performance of the sensor. Results also show that the deviation between the actual and desired values caused by the backlash characteristics of the Bowden cable. Moreover, the deviation changes in different conditions and is dependent on velocity and orientation. Therefore, an effective compensation method is proposed to reduce the deviation in the experiment.
Estimation of a Non-Parametric Principal-Agent Model with Hidden Actions

Principal-agent models are essential to the analysis of incentive contracts. Despite their prevalence, existing work on estimating principal-agent models from contract data – which can be valuable for evaluating counterfactuals and designing incentives in practice – is limited. In this paper, we propose an estimator for a non-parametric principal-agent model where agent actions are hidden. We show the estimator to be statistically consistent, and show that the unobservability of agent actions can make the estimation problem NP-hard. While the estimator can be expressed exactly as an integer program, the resulting formulation scales poorly in the size of the data due to weak linear programming relaxations. To bypass this deficiency, we present an approximate estimator, also formulated as an integer program, along with a “statistical” column generation algorithm that relies on using hypothesis tests to identify variables to introduce into the model. We show that our solution algorithm preserves statistical consistency, and present a bound on the expected iteration count as a function of the Type I error rate. Numerical results show that our statistical column generation algorithm dramatically reduces the computational time required to obtain competitive parameter estimates compared to off-the-shelf solvers. Lastly, we apply our estimation procedure to a dataset from a large Medicare program, and derive associated policy recommendations.
Effect of Sodium Hexametaphosphate on the Solution of Lead

AT A joint meeting of the New England Health Institute, the New JLJL England Water Works Association and the New England Sewage Works Association, held in April 1941, Dr. L. T. Fairhall of the National Institute of Health questioned the use of sodium hexametaphosphate for corrosion control in systems containing lead pipe. Dr. Fairhall had found that concentrations of metaphosphate of about 1,000 ppm. produced large increases in the solubilities of some of the common lead salts. Ruchhoft and Kachmar (1) subsequently confirmed FairhalFs experiments, but allayed much of the anxiety that had been produced with respect to the use of metaphosphate by showing that in quantities of 1 to 10 ppm. , the metaphosphate actually decreased the solubilities of lead salts. Hatch (2) published results on the effect of metaphosphate on the corrosion of lead wool, in which he showed that the solution of lead from the cleaned metal was markedly inhibited in waters of pH 6.0 or below. At and above pH 7.0, his results gave some indication that the metaphosphate slightly increased the solution of lead. It has seemed to the writers that the gravest question with respect to the introduction of metaphosphate into water systems containing lead pipe is that of the effect of this chemical on the deposits of lead salts previously formed in the pipe. Metaphosphate has been known to cause rapid removal of pipe deposits in some systems in which it has been introduced, and such removal would be particularly dangerous if the deposits contained a high percentage of lead. It has also seemed desirable to provide independent confirmation of the results of the investigators cited above, since the problem is significant to public health. In all experiments presented in this paper, the lead concentrations were determined by the dithizone method as described in Standard Methods (3). The only modification adopted consisted of the use of a Cenco-Sheard
Preparation and properties of Ce0.8Ca0.2O1.8 anode material by glycine-nitrate process

Ce0.8Ca0. 2O1.8 (CDC82 ) 阳极材料被 glycine 硝酸盐过程(GNP ) 准备。 Thermogravimetric (TG ) 分析和微分扫描量热的(DSC ) 方法被采用描绘 CDC82 材料的反应过程。 X 光检查 diffractometry (XRD ) ，扫描电子缩微本(SEM ) ，指导电流四探查(四探查的 DC ) ，温度过程还原剂(TPR ) 技术被采用描绘 CDC82 材料的性质。 在先锋是在为 4 h 的 750 ° C 的 sintered 以后，有纯荧石的结构和纳米尺寸的 CDC82 材料被获得。 CDC82 的全部的传导性在 50 850 ° C 在空中与温度改变很少，并且最大的价值是在 750 ° C 的 0.04 S/cm。 当空气从空气改变到氢时，全部的传导性完全变得更大，它极大地与增加温度增加并且在 850 ° C 到达 1.09 S/cm 的最大的价值。 象 CeMg 和 La2O3 那样的一些杂质在 CDC82 阳极和 La1-xSrxGa1-yMgyO3- δ(LSGM ) 电解质材料的混合以后存在是在为 15 h 的 1 200 ° C 的 sintered。 阳极材料为氢和甲烷有优秀催化性质的 CDC82 材料。
Trajectory Prediction of Vehicles Based on Deep Learning

In order to safely and efficiently drive through the complex traffic scenarios, predicting the trajectory of the forward vehicle accurately is important for intelligent vehicles. Accurate and realtime trajectory prediction can make the intelligent vehicles adjust their maneuvers according to the running state of the vehicles in front of them. In recent years, deep-learning-based methods have been applied as novel alternatives for trajectory prediction with the development of the machine learning. But which kind of deep neural networks is the most suitable model for trajectory prediction is uncertain. In this paper, we design three kinds of deep neural networks: Long Short Term Memory (LSTM), Gated Recurrent Units (GRU), and Stacked Autoencoders (SAEs) to predict the position and the velocity of the forward vehicles. We verify the performance of these three network models on the NGSIM I-80 dataset which consists of real trajectories of vehicles on multi-lanes. What’s more, we use Savitzky-Golay filter to filter noise in order to reduce the effect of noise on the training models. Our results demonstrate that in the three deep neural networks that we designed, the LSTM model perform better than GRU model and SAEs model in the area of trajectory prediction. The results of our works will have certain guiding significance for choosing the model of neural network to predict the vehicle trajectories.