Miracle-dz/UniFAR-FTUs huggingface dataset:
Bounds on light sterile neutrino mass and mixing from cosmology and laboratory searches

We provide a consistent framework to set limits on properties of light sterile neutrinos coupled to all three active neutrinos using a combination of the latest cosmological data and terrestrial measurements from oscillations, $\beta$-decay and neutrinoless double-$\beta$ decay ($0\nu\beta\beta$) experiments. We directly constrain the full $3+1$ active-sterile mixing matrix elements $|U_{\alpha4}|^2$, with $\alpha \in ( e,\mu ,\tau )$, and the mass-squared splitting $\Delta m^2_{41} \equiv m_4^2-m_1^2$. We find that results for a $3+1$ case differ from previously studied $1+1$ scenarios where the sterile is only coupled to one of the neutrinos, which is largely explained by parameter space volume effects. Limits on the mass splitting and the mixing matrix elements are currently dominated by the cosmological data sets. The exact results are slightly prior dependent, but we reliably find all matrix elements to be constrained below $|U_{\alpha4}|^2 \lesssim 10^{-3}$. Short-baseline neutrino oscillation hints in favor of eV-scale sterile neutrinos are in serious tension with these bounds, irrespective of prior assumptions. We also translate the bounds from the cosmological analysis into constraints on the parameters probed by laboratory searches, such as $m_\beta$ or $m_{\beta \beta}$, the effective mass parameters probed by $\beta$-decay and $0\nu\beta\beta$ searches, respectively. When allowing for mixing with a light sterile neutrino, cosmology leads to upper bounds of $m_\beta < 0.09$ eV and $m_{\beta \beta} < 0.07$ eV at 95\% C.L, more stringent than the limits from current laboratory experiments.
Laplacian MinMax Discriminant Projection and its Applications

A new algorithm, Laplacian MinMax Discriminant Projection (LMMDP), is proposed in this paper for supervised dimensionality reduction. LMMDP aims at learning a discriminant linear transformation. Specifically, we define the within-class scatter and the between-class scatter using similarities which are based on pairwise distances in sample space. After the transformation, the considered pairwise samples within the same class are as close as possible, while those between classes are as far as possible. The structural information of classes is contained in the within-class and the between-class Laplacian matrices. Therefore, the discriminant projection subspace can be derived by controlling the structural evolution of Laplacian matrices. The performance on several data sets demonstrates the competence of the proposed algorithm.
Toward Sim-to-Real Directional Semantic Grasping

We address the problem of directional semantic grasping, that is, grasping a specific object from a specific direction. We approach the problem using deep reinforcement learning via a double deep Q-network (DDQN) that learns to map downsampled RGB input images from a wrist-mounted camera to Q-values, which are then translated into Cartesian robot control commands via the cross-entropy method (CEM). The network is learned entirely on simulated data generated by a custom robot simulator that models both physical reality (contacts) and perceptual quality (high-quality rendering). The reality gap is bridged using domain randomization. The system is an example of end-to-end (mapping input monocular RGB images to output Cartesian motor commands) grasping of objects from multiple pre-defined object-centric orientations, such as from the side or top. We show promising results in both simulation and the real world, along with some challenges faced and the need for future research in this area.
Low‐ripple coarse‐fine digital low‐dropout regulator without ringing in the transient state

Herein, a low‐ripple coarse‐fine digital low‐dropout regulator (D‐LDO) without ringing in the transient state is proposed. Conventional D‐LDO suffers from a ringing problem when settling the output voltage at a large load transition, which increases the settling time. The proposed D‐LDO removes the ringing and reduces the settling time using an auxiliary power stage which adjusts its output current to a load current in the transient state. It also achieves a low output ripple voltage using a comparator with a complete comparison signal. The proposed D‐LDO was fabricated using a 65‐nm CMOS process with an area of 0.0056 μm2. The undershoot and overshoot were 47 mV and 23 mV, respectively, when the load current was changed from 10 mA to 100 mA within an edge time of 20 ns. The settling time decreased from 2.1 μs to 130 ns and the ripple voltage was 3 mV with a quiescent current of 75 μA.
Novel AHDC1 Gene Mutation in a Brazilian Individual: Implications of Xia-Gibbs Syndrome

Xia-Gibbs syndrome (XGS) is a rare neurological disorder characterized by global developmental delay, hypotonia, intellectual disability, seizures, and sleep apnea. XGS is defined by monoallelic pathogenic variants in AHDC1. In this study, we identified a Brazilian patient carrying a likely de novo AHDC1 nonsense mutation (c.451C>T; p.Arg151*) which was absent in both parents. All disease-causative variants already associated with XGS have been reviewed and the mutation described here corresponds to the closest one to the N-terminal region. Our findings were discussed based on the suggested genotype-phenotype correlation of the disease.
Predicting primary site of secondary liver cancer with a neural estimator of metastatic origin

Abstract. Purpose: Pathologists rely on relevant clinical information, visual inspection of stained tissue slide morphology, and sophisticated molecular diagnostics to accurately infer the biological origin of secondary metastatic cancer. While highly effective, this process is expensive in terms of time and clinical resources. We seek to develop and evaluate a computer vision system designed to reasonably infer metastatic origin of secondary liver cancer directly from digitized histopathological whole slide images of liver biopsy. Approach: We illustrate a two-stage deep learning approach to accomplish this task. We first train a model to identify spatially localized regions of cancerous tumor within digitized hematoxylin and eosin (H&E)-stained tissue sections of secondary liver cancer based on a pathologist’s annotation of several whole slide images. Then, a second model is trained to generate predictions of the cancers’ metastatic origin belonging to one of three distinct clinically relevant classes as confirmed by immunohistochemistry. Results: Our approach achieves a classification accuracy of 90.2% in determining metastatic origin of whole slide images from a held-out test set, which compares favorably to an established clinical benchmark by three board-certified pathologists whose accuracies ranged from 90.2% to 94.1% on the same prediction task. Conclusions: We illustrate the potential impact of deep learning systems to leverage morphological and structural features of H&E-stained tissue sections to guide pathological and clinical determination of the metastatic origin of secondary liver cancers.
Size‐Extensive Molecular Machine Learning with Global Representations

Machine learning (ML) models are increasingly used in combination with electronic structure calculations to predict molecular properties at a much lower computational cost in high-throughput settings. Such ML models require representations that encode the molecular structure, which are generally designed to respect the symmetries and invariances of the target property. However, size-extensivity is usually not guaranteed for so-called global representations. In this contribution, we show how extensivity can be built into global ML models using, e
Practice and problems regarding oral hygiene: study among female medical undergraduate students of tertiary care hospital, Pune, India

Background: As a health provider to community, a doctor should himself be aware of his oral health and undergraduate medical students who are future health professionals should also be well aware of their dental hygiene. Hence with an aim to assess the practice and problems about dental hygiene amongst female medical undergraduate students, this study was planned. Objective of the study was to assess the practices and problems regarding oral hygiene among female undergraduate medical students and efforts taken by them to solve these problems. Method: A cross-sectional study was undertaken among female undergraduate medical students residing in a hostel of a medical college. Results: 56.7% girls were using soft tooth brush, 69.3% students change their tooth brush every 6 monthly and 63.3% of them were brushing only once in a day. 79.3% were rinsing teeth after snack or meal. The percentage of students who were using mouth wash and tongue cleaner was 27.3% and 52% respectively. Bad breath was faced by only 9.33% of students, 39.33% were having cavities and 49.33% were having problem of plaque. 25.3% had never visited dentist. Scaling was performed by only 24.7% students and among them only 1.33% did it 6 monthly. It was observed that students using mouth wash 22.2% had significantly less problem of bad breath as compared to students who were not using 6.7%. Significantly larger numbers of students, with problem of cavities were observed to use mouth wash 60% and floss 68% as compared to those who did had this complaint. Conclusion: The study highlights the fact that preventive behaviour among medical students increased after they experienced some or the other oral health problem for which they were advised to follow these preventive practices so that the severity and extent of the disease does not progress. Further research is required on a larger scale so that the ways to increase the promotive and preventive oral health practices can be identified (e.g. behaviour change communication) to prevent the occurrence of oral health problems.
Comparative evaluation of the effect of curcumin and chlorhexidine on human fibroblast viability and migration: An in vitro study

Background and Objective: Chemical plaque control acts as an adjunct to mechanical periodontal therapy. Chlorhexidine (CHX) is considered as the gold standard in chemical plaque control, but the main concern is about its fibroblast cytotoxicity. Curcumin, a lipophilic polyphenol, may offer as a promising antiplaque agent. This study was conducted to compare the effect of curcumin (0.003%, 0.03%, 0.06%, 0.1%, and 0.12%) and CHX (0.03%, 0.06%, 0.1%, 0.12%, and 0.2%) on gingival fibroblast cell viability and wound healing at different time periods (1, 2, 4, 6, 8, and 10 min). Materials and Methods: The minimum inhibitory concentration (MIC50) was determined before the evaluation of cytotoxicity and wound healing property. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and morphological examination by direct invert microscopy were carried out to determine cytotoxicity. Wound healing was evaluated by scratch wound assay. Results and Discussion: The MIC50 of CHX and curcumin was at 0.1% and 0.003%, respectively. The mean percentage of fibroblast viability at different concentrations of CHX and curcumin at each time period showed a significant difference. Curcumin exhibited less cytotoxicity as compared to CHX at all concentrations and at varying time periods. There was a significant difference between mean percentage of fibroblast viability at MIC50 of CHX (0.1%) and curcumin (0.003%) at different time periods. The difference between percentage wound healing at antibacterial concentrations of CHX and curcumin at varying time periods was significant. Conclusion: The antibacterial concentration of curcumin (0.003%) exhibits less fibroblast cytotoxicity and excellent wound healing property as compared to CHX. Curcumin may offer as a promising chemical plaque control agent which is less cytotoxic, cost-effective, safe, easily available, and with a possibly beneficial effect on wound healing.
Cone beam computed tomography – the importance of z-axis

Background: Conventional imaging is the backbone of dentistry. Intraoral and extraoral radiographs are commonly used for diagnosis and clinical management for multiple maxillofacial pathologies. However, they are of a two-dimensional nature and have numerous limitations and disadvantages. Cone beam computed tomography (CBCT) adds a third dimension to the two-dimensional image. The multiple pathological conditions that remain undetected in two-dimensional imaging can be easily diagnosed with CBCT and, to a large extent, help with treatment planning and prognosis. Aim: To compare intraoral and extraoral two-dimensional imaging to CBCT to prove the importance of CBCT in diagnosis and treatment planning. Setting and Design: Different cases in which patients underwent two-dimensional intraoral / extraoral imaging and CBCT were reported and variations in radiographic diagnosis were compared. Conclusion: CBCT is a boon to dentistry. The third dimension adds invaluable information that modifies the diagnosis and treatment plan and hence helps improve the prognosis.
Mantle cell lymphoma presented as cryoglobulinemic vasculitis

Mantle cell lymphoma (MCL) is an uncommon subtype of B-cell lymphoproliferative neoplasm which often presents as lymphadenopathy or organomegaly. Herein, we present the case of a 69-year-old male who developed the rapid onset of cyanotic digits and nose. Cryoglobulin was detected, and a skin biopsy showed occlusive vasculopathy, which suggested cryoglobulinemic vasculitis. A bone marrow biopsy confirmed the diagnosis of cyclin D1-negative, SOX11-positive MCL. He received systemic immunochemotherapy including bortezomib and rituximab, and his cryoglobulinemia completely resolved. In addition, his lymphoma remains in complete remission 2 years after the diagnosis.
Management of pemphigus vulgaris with rituximab: A case report and brief review on emerging treatment options

Pemphigus vulgaris is the most common autoimmune vesiculobullous disorders. It presents with flaccid bullae on the skin and erosions on the mucosa. Severe cases can be life-threatening and hence prompt treatment can prevent untoward consequences. Earlier, steroids were the mainstay of treatment but it causes further medical problems. Nevertheless, new studies have emerged about the pathogenesis of the diseases and treatment protocols have been updated with newer drugs that had comparatively less adverse effects. We report a case of pemphigus vulgaris with extensive involvement of skin and oral mucosa treated with rituximab and adjuvant immunosuppressants and a brief update on various treatment protocols.
Bluetongue Serotype 3 in Israel 2013–2018: Clinical Manifestations of the Disease and Molecular Characterization of Israeli Strains

In this paper, the results of the diagnostic activities on Bluetongue virus serotype 3 (BTV-3) conducted at Kimron Veterinary Institute (Beit Dagan, Israel) between 2013 and 2018 are reported. Bluetongue virus is the causative agent of bluetongue (BT), a disease of ruminants, mostly transmitted by competent Culicoides species. In Israel, BTV-3 circulation was first detected in 2013 from a sheep showing classical BT clinical signs. It was also evidenced in 2016, and, since then, it has been regularly detected in Israeli livestock. Between 2013 and 2017, BTV-3 outbreaks were limited in sheep flocks located in the southern area only. In 2018, BTV-3 was instead found in the Israeli coastal area being one of the dominant BTV serotypes isolated from symptomatic sheep, cattle and goats. In Israeli sheep, BTV-3 was able to cause BT classical clinical manifestations and fatalities, while in cattle and goats infection ranged from asymptomatic forms to death cases, depending on either general welfare of the herds or on the occurrence of viral and bacterial co-infections. Three different BTV-3 strains were identified in Israel between 2013 and 2018: ISR-2019/13 isolated in 2013, ISR-2153/16 and ISR-2262/2/16 isolated in 2016. Sequencing and phylogenetic analysis of these strains showed more than 99% identity by segment (Seg) 2, 5, 6, 7, and 8 sequences. In contrast, a wide range of diversity among these strains was exhibited in other viral gene segments, implying the occurrence of genome reassortment between these local circulating strains and those originating from Africa. The genome sequences of the BTV-3 isolated in 2017 and 2018 were most closely related to those of the ISR-2153/16 strain suggesting their common ancestor. Comparison of BTV-3 Israeli strains with those recently detected in the Mediterranean region uncovered high percentage identity (98.19–98.28%) only between Seg-2 of all Israeli strains and the BTV-3 Zarzis/TUN2016 strain. A 98.93% identity was also observed between Seg-4 sequences of ISR-2019/13 and the BTV-3 Zarzis/TUN2016 strain. This study demonstrated that BTV-3 has been circulating in the Mediterranean region at least since 2013, but, unlike the other Mediterranean strains, Israeli BTV-3 were able to cause clinical signs also in cattle.
Combined Diffusion Tensor Imaging and Quantitative Susceptibility Mapping Discern Discrete Facets of White Matter Pathology Post-injury in the Rodent Brain

Early loss of white matter microstructure integrity is a significant cause of long-term neurological disorders following traumatic brain injury (TBI). White matter abnormalities typically involve axonal loss and demyelination. In-vivo imaging tools to detect and differentiate such microstructural changes are not well-explored. This work utilizes the conjoint potential offered by advanced magnetic resonance imaging techniques, including quantitative susceptibility mapping (QSM) and diffusion tensor imaging (DTI), to discern the underlying white matter pathology at specific time points (5 h, 1, 3, 7, 14, and 30 days) post-injury in the controlled cortical impact mouse model. A total of 42 animals were randomized into six TBI groups (n = 6 per group) and one sham group (n = 6). Histopathology was performed to validate in-vivo findings by performing myelin basic protein (MBP) and glial fibrillary acidic protein (GFAP) immunostaining for the assessment of changes to myelin and astrocytes. After 5 h of injury radial diffusivity (RD) was increased in white matter without a significant change in axial diffusivity (AxD) and susceptibility values. After 1 day post-injury RD was decreased. AxD and susceptibility changes were seen after 3 days post-injury. Susceptibility increases in white matter were observed in both ipsilateral and contralateral regions and persisted for 30 days. In histology, an increase in GFAP immunoreactivity was observed after 3 days post-injury and remained high for 30 days in both ipsilateral and contralateral white matter regions. A loss in MBP signal was noted after 3 days post-injury that continued up to 30 days. In conclusion, these results demonstrate the complementary ability of DTI and QSM in discerning the micro-pathological processes triggered following TBI. While DTI revealed acute and focal white matter changes, QSM mirrored the temporal demyelination in the white matter tracts and diffuse regions at the chronic state.
The Influence of Baseline Alzheimer's Disease Severity on Cognitive Decline and CSF Biomarkers in the NILVAD Trial

We examined the effects of a dihydropyridine calcium channel blocker nilvadipine with anti-inflammatory properties on cognition and cerebrospinal fluid (CSF) biomarkers by baseline Alzheimer's disease (AD) severity. Exploratory analyses were performed on the dataset (n = 497) of a phase III randomized placebo-controlled trial to examine the response to nilvadipine in AD subjects stratified by baseline AD severity into very mild (MMSE ≥ 25), mild (MMSE 20-24) and moderate AD (MMSE < 20). The outcome measures included total and subscale scores of the Alzheimer's Disease Assessment Scale Cognitive 12 (ADAS-Cog 12), the Clinical Dementia Rating Scale sum of boxes (CDR-sb) and the AD composite score (ADCOMS). Cerebrospinal fluid biomarkers Aβ38, Aβ40, Aβ42, neurofilament light chain (NFL), neurogranin, YKL-40, total tau and P181 tau (ptau) were measured in a subset of samples (n = 55). Regression analyses were adjusted for confounders to specifically examine the influence of nilvadipine and baseline AD severity on cognitive outcomes over 78-weeks. Compared to their respective placebo-controls, nilvadipine-treated, very mild AD subjects showed less decline, whereas moderate AD subjects showed a greater cognitive decline on the ADAS-Cog 12 test and the ADCOMS. A lower decline was observed after nilvadipine treatment for a composite memory trait in very mild AD subjects and a composite language trait in mild AD subjects. Cerebrospinal fluid Aβ42/Aβ40 ratios were increased in mild AD and decreased in moderate AD patients treated with nilvadipine, compared to their respective controls. Among moderate AD subjects, levels of ptau, total tau, neurogranin and YKL-40 increased in subjects treated with nilvadipine compared to placebo. These studies suggest that baseline AD severity influenced the treatment outcome in the NILVAD trial and that future clinical trials of nilvadipine should be restricted to mild and very mild AD patients. Trial Registration: NCT02017340 Registered 20 December 2013, https://clinicaltrials.gov/ct2/show/NCT02017340 EUDRACT Reference Number 2012-002764-27 Registered 04 February 2013, https://www.clinicaltrialsregister. eu/ctr-search/search? query=2012-002764-27
Comparative Clinical Study Between Modified Ureteral Orthotopic Reimplantation and Cohen Method Under Pneumovesicum in Pediatric Patients With Hydroureteronephrosis

Purpose: To report our initial experience with a modified ureteral orthotopic reimplantation technique under pneumovesicum and compare the outcomes vs. those obtained with the Cohen technique under pneumovesicum for the correction of primary obstructive megaureter (POM) or vesicoureteral reflux(VUR) in pediatric patients. Methods: A total of 46 patients (38 POM and 8 VUR; mean age: 16.24 months) treated with modified ureteral orthotopic reimplantation (OR) and 43 patients (34 POM and 9 VUR; mean age: 22.98 months) treated with Cohen reimplantation (CR) under pneumovesicum were included. We compared the results perioperatively and during follow-up. Results: The mean operative time was significantly shorter in the OR group (OR: 86.86 and 108.18 vs. CR: 95.14 and 124.29 min for unilateral and bilateral cases, respectively). The mean postoperative hospital stay (OR: 5.02 vs. CR: 5.07 days), blood loss (OR: 3.67 vs. CR: 3.84 ml), and follow-up time (OR: 23.17 vs. CR: 23.37 months) did not exhibit significant differences between the two groups. One patient converted to open surgery in the CR group, whereas there was no conversion in the OR group. Postoperative febrile urinary tract infection occurred in two cases in each group. Both infections were controlled using antibiotics. All patients in both groups showed improved hydroureteronephrosis, and all patients with VUR showed reflux resolution post-surgery. Conclusions: Our modified ureteral orthotopic reimplantation technique under pneumovesicum can be safely and effectively performed, achieving a high success rate that is equivalent to that obtained through the Cohen technique under pneumovesicum. Moreover, it involves a simpler procedure and shorter operation time.
The Falling Body Problem in Quantum Calculus

The quantum calculus, q-calculus, is a relatively new branch in which the derivative of a real function can be calculated without limits. In this paper, the falling body problem in a resisting medium is revisited in view of the q-calculus to the first time. The q-differential equations describing the vertical velocity and distance of the body are obtained. Accordingly, exact expressions for the vertical velocity and the vertical distance are provided. The solutions are expressed in terms of the small q-exponential function which is an elementary function in the q-calculus. The dimensionality of the obtained formulae of the velocity and the distance are also analyzed. In addition, the present exact solutions reduce to the corresponding solutions in classical Newtonian mechanics when the quantum parameter q tends to one.