Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects Of Orally Fed Diazinon On Some Biochemical Parameters Of Male Albino Rats

Background:The current investigation was carried out to study the effect of orally administration of diazinon insecticide on some biochemical blood indices on male albino rats. Material and methods: The organophosphorus insecticide , diazinon was orally administrated at a dose (100mg/kg body weight=1/3LD50) , daily for 10 days (short –term) and 20 days (long –term) to adult male albino rats . Results: The results revealed the following: 1- Diazinon led to an increase in rat blood serum glucose& T3 (short and long –term); AST,ALT, and T4 (long-term). 2- Diazinon reduced the serum content of total cholesterol and protein in short–term treated rats. 3- Treatment of rats with diazinon did not alter activity of AST, ALT and T4 level at short –term period . In addition ; ALP serum levels were not altered in both short and long –term treated rats .
Strategies based on sum of peak intensities may better reflect protein expression than peak area integration in iTRAQ protein expression measurement by LC-MS/MS using a TripleTOF 5600+ platform

In the field of quantitative proteomics, the Isobaric Tags for Relative & Absolute Quantitation (iTRAQ) technology has demonstrated efficacy for proteome monitoring despite its lack of a consensus for data handling. In this study, after peptide and protein identification, we compared the widespread quantitation method based on the calculation of MS/MS reporter ion peaks areas ratios (ProteinPilot) to the alternative method based on the calculation of ratios of the sum of peak intensities (jTRAQx (Quant)) and we processed output data with the in-house Customizable iTRAQ Ratios Calculator (CiR-C) algorithm. Quantitation based on peak area ratios displayed no significant linear correlation with Western blot quantitation. In contrast, quantitation based on the sum of peak intensities displayed a significant linear association with Western blot quantitation (non-zero slope; Pearson correlation coefficient test, r = 0.2962, p = 0.0099 **) with an average bias of 0.08747 ± 0.5004 and 95% Limits of Agreement from - 0.8932 to 1.068. We proposed the Mascot-jTRAQx-CiR-C strategy as a simple yet powerful data processing adjunct to the iTRAQ technology.
Investigation and compare the effects of two weight loss protocols on lactic acid in wrestlers

Weight loss in many sports that involve weight classes is very important; the weight can have a major role in the success of athletes. The aim of this investigation was examining the effect of rapid and gradual weight loss protocols on lactic acid in trained wrestlers. Twenty-two trained wrestlers [age 20–25 years] volunteered to research and randomly assigned into two groups: rapid and gradual weight loss group. Group 1 applied rapid weight loss method in 48-h and group 2 used twelve days gradual method. All subjects asked for a reduction of about 4 percent of their weight. Before and after weight loss intervention, lactic acid was measured. The results demonstrated that the amount of increase in lactic acid in the rapid weight loss group was more than gradual group after tests. Comparison of these two weight loss protocols exhibited that in compare with rapid weight loss, the gradual weight-loss method leads to a lesser decrease in wrestlers' metabolic changes.
PSYCHOLOGICAL IMPACT OF SEXUAL VIOLENCE IN CHILDREN: SYSTEMATIC LITERATURE REVIEW

Sexual violence in children is a relationship or interaction between a child and an older person or an adult such as a stranger, sibling or parent in which the child is used as a satisfying object for the sexual needs of the perpetrator. This action is carried out using coercion, threats, bribery, deception, and even pressure. One in five girls and one in thirteen boys reported having experienced sexual violence worldwide, and the prevalence of sexual violence ranged from 15.3% in girls and 13.8% in boys. This Systematic Literature Review employed two PubMed and Sciencedirect databases during 2008-2018. The stages in this systematic literature review were identifying research questions, identifying relevant studies, choosing relevant studies, conducting critical assessments, extracting data and mapping. There were 767 initial articles identified. This study analyzed 11 articles that met the requirements for reference. Children who experienced sexual violence in their childhood had a severe psychological impact in the form of anxiety, depression, personality disorders, post-traumatic stress disorder (PTSD), psychosis, drug and alcohol abuse, bulimia and suicide. Most children who experienced sexual violence had a psychological impact in the form of depression, anxiety, post-traumatic stress disorder, suicide, and sexual behavior. Children who experienced sexual violence often committed acts of sexual violence to others. It was the psychological impact that they experienced. Keywords : psychological impact, sexual violence, children
Reduction in the Viability of Human Cervical Cancer HeLa Cell Line via Indirect Co-culture With Amniotic Fluid-Derived Mesenchymal Stem Cells

Objectives: This experiment was carried out to evaluate the impacts of unmodified human amniotic fluid-derived mesenchymal stromal/stem cells (hAF-MSCs) on the viability of HeLa cells, as well as the impact of these cells on the expression of common proapoptotic and pro-survival genes in tumor cells by establishing an indirect co-culture system. Materials and Methods: To this end, an indirect co-culture system was established, and hAF-MSCs were co-cultured with HeLa cells at a ratio of 1:2 for five days. The cell viability of co-cultured tumor cells was determined after the incubation period. Then, several parameters were examined, including the gene expression of tumor protein 53 (TP53), BCL2-associated X protein (BAX), B-cell lymphoma 2 (BCL-2), and cyclin-dependent kinase inhibitor 1A (CDKN1A). Finally, gene regulatory networks were analyzed as well. Results: The results of this study confirmed that the co-culture of hAF-MSCs with HeLa cells could decrease the viability of tumor cells. The reduction of HeLa cell viability was accompanied by an increase in BAX, TP53, and CDKN1A while a decrease in BCL2 gene expression. Eventually, the analysis of the regulatory network revealed that the co-culture of Hela ¬cells with hAF-MSCs activated several transcriptional factors and microRNAs which regulated the expression of these genes. Conclusions: In general, hAF-MSCs exerted the inhibitive effects on the growth of HeLa cells, along with alterations in the expression of common pro-apoptotic and pro-survival genes in a timely and concentration-dependent manner.
Proposals on the Root Data Domain Gateway and System Operations for IoT Data Interoperability

With the increasing developments in the Internet of Things (IoT), smart-city applications have been attracting widespread interest in many governments, organizations, and companies. The FED4IoT project is a research and innovation project that aims to develop a smart-city application, named “VirIoT,” which realizes the semantic interoperability of IoT data among numerous IoT applications from different grounds. To realize the semantic interoperability of IoT data, data management on cloud platforms, such as FIWARE, is considered necessary. Therefore, the development of a root data domain gateway (RDG), which analyzes IoT data, converts its data format, and posts the data to the cloud service, is required. In this project, Kanazawa Institute of Technology has chosen wildlife monitoring as one of the use cases of the project, and its system using IoT has been designed and developed. Furthermore, its data model has been created for the development of the RDG. Finally, the RDG has been developed as a first step in the semantic interoperability of IoT data.
Resonance hairpin probe for electronegative plasma diagnostics

The practical applications of resonance hairpin probe for characterizing electronegative plasma is investigated. In particular the hairpin probe was operated in a time-resolved mode for measuring the electron density evolution during pulsed laser photodetachment of negative ions in an oxygen inductively coupled plasma (ICP) discharge. From the temporal evolution of the electron density, the negative ion temperature is determined from the characteristic diffusion time of negative ions in the photodetached channel. This is compared with an independent method based on the temporal evolution of the plasma potential during photodetachment measured by a floating emissive probe. Temporal evolution of negative oxygen ions in a pulsed dc magnetron discharge is also obtained using pulsed photodetachment and a time-resolved hairpin probe. The results are found to be in reasonably good agreement with those measured from Langmuir probe assisted photodetachment. Two important applications addressed in this thesis are the use of steady state and pulse biased hairpin probes. For overcoming the limitations arising because of the finite sheath width around the resonator pins, the hairpin was systematically biased at strong negative dc potentials (eφ >> kTe) with respect to the plasma. A plot of resonance frequency verses probe bias is shown to provide a unique value for the electron density. Comparison of the sheath corrected electron density based on the step front sheath model and that obtained with a planar Child-Langmuir sheath approximation, were found to be in good agreement at higher densities (above 1x10 16 m-3), however small deviations were observed at lower densities (below 3x1015 m-3) due to deviation from a planar sheath assumption. Finally, qualitative measurement of negative ion parameters is performed by pulse biasing the hairpin probe. Comparison of the temporal evolution of the electron density before and post application of a negative pulse bias allows one to obtain both the negative ion density, negative ion temperature, as well as the positive ion density. The relative measurements of the negative ion parameters using this technique are found to be in reasonably good agreement with the hairpin probe assisted laser photodetachment however the absolute measurements are underestimated by a factor of 10. The discrepancy in the measured absolute negative ion parameters and the limitations behind this technique are discussed.
An Online Community Site that Incorporates the use of Social Networks Software: A Case of an Open University in Thailand

In the digital period, a large part of our daily activities revolves around social networks software. Social networks software, such as Facebook and Twitter, have brought new opportunities for users to create online communities, share content and opinions on the online platforms. Today’s colleges and universities have also employed the power of social media to increase students’ interaction and engagement. This is particularly useful for online or distance learners, where face-to-face communication is limited. This paper aims to determine requirements for an online community site that incorporates the use of social networks software. The requirements were gathered from stakeholders at an open university in Thailand. The study proposes the desired characteristics and functional requirements of an online community site in a distance learning context.
Photosynthesis in co-occurring invasive Acacia spp. and native Bornean heath forest trees at the post-establishment invasion stage

ABSTRACT Seedlings of invasive species often exhibit superior physiological traits that facilitate their spread at early stages of invasion, although it is unclear whether these traits persist at the post-establishment stage. To determine whether mature exotic Acacia spp. possess superior traits over mature native plants, we compared foliar gas exchange and chlorophyll a fluorescence of Acacia auriculiformis and Acacia mangium coexisting with tropical heath forest tree species Buchanania arborescens and Dillenia suffruticosa in Brunei Darussalam. The CO2 assimilation rates of Acacia spp. were significantly higher than those of heath species at current prevailing conditions of ~400 ppm ambient CO2, 1,500 µmol m−2 s−1 photosynthetically active radiation and 30°C leaf temperature. The photosystem II of Acacia spp. exhibited significantly higher maximum quantum yield of primary photochemistry at comparable temperatures, and was more sensitive to an elevated temperature (42°C for 1 h). Better photosynthetic performance of Acacia spp. , due to larger stomatal openings, better light harvesting efficiency, and greater plasticity in photosystem II, may enable adult Acacia trees to sustain a competitive growth advantage and suppress native tropical heath forest species. The competitive advantage maintained by Acacia spp. in post-establishment stage likely facilitates the establishment of monospecific Acacia stands in invaded heath forests.
Effect of Drought on Outbreaks of Major Forest Pests, Pine Caterpillars (Dendrolimus spp.), in Shandong Province, China

As the main defoliators of coniferous forests in Shandong Province, China, pine caterpillars (including Dendrolimus suffuscus suffuscus Lajonquiere, D. spectabilis Butler, and D. tabulaeformis Tsai et Liu) have caused substantial forest damage, adverse economic impacts, and losses of ecosystem resources. Therefore, elucidating the effects of drought on the outbreak of these pests is important for promoting forestry production and ecological reconstruction. Accordingly, the aim of the present study was to analyse the spatiotemporal variation of drought in Shandong Province, using the Standard Precipitation Index, and to investigate the impact of drought on the outbreak of pine caterpillar infestations. Future trends in drought and pine caterpillar populations were then estimated using the Hurst exponent. The results showed that: (1) Drought decreased gradually and showed a wetting trend from 1981 to 2012, with frequency decreasing on a decadal scale as follows: 1980s > 1990s > 2000s > 2010s; (2) The total area of pine caterpillar occurrence decreased strongly from 1992 to 2012; (3) Long-term or prolonged drought had a greater positive impact on pine caterpillar outbreak than short-term drought; (4) In the future, a greater portion of the province’s area will experience increased wetting conditions (57%) than increased drought (43%), and the area of pine caterpillar outbreak is estimated to decrease overall. These findings help elucidate the relationship between drought and pine caterpillar outbreak in Shandong Province and, hence, provide a basis for developing preventive measures and plans.
Genetic determinants in Salmonella enterica serotype Typhimurium required for overcoming stressors in the host environment

Salmonella enterica serovar Typhimurium (S. Typhimurium), a non-typhoidal Salmonella (NTS), result in a range of diseases, including self-limiting gastroenteritis, bacteremia, enteric fever, and focal infections representing a major disease burden worldwide. There is still a significant portion of Salmonella genes whose functional basis to overcome host innate defense mechanisms, consequently causing disease in host, largely remains unknown. Here, we have applied a high-throughput transposon sequencing (Tn-seq) method to unveil the genetic factors required for the growth or survival of S. Typhimurium under various host stressors simulated in vitro. A highly saturating Tn5 library of S. Typhimurium 14028s was subjected to selection during growth in the presence of short chain fatty acid (100 mM propionate), osmotic stress (3% NaCl) or oxidative stress (1 mM H2O2) or survival in extreme acidic pH (30 min in pH3) or starvation (12 days in 1X PBS). We have identified an overlapping set of 339 conditionally essential genes (CEGs) required by S. Typhimurium to overcome these host insults. Interestingly, entire eight genes encoding F0F1-ATP synthase subunit proteins were required for fitness in all five stresses. Intriguingly, total 88 genes in Salmonella pathogenicity island (SPI), including SPI-1, SPI-2, SPI-3, SPI-5, SPI-6 and SPI-11 are also required for fitness under the in vitro conditions evaluated in this study. Additionally, by comparative analysis of the genes identified in this study and the genes previously shown to be required for in vivo fitness, we identified novel genes (marBCT, envF, barA, hscA, rfaQ, rfbI and putative proteins STM14_1138, STM14_3334, STM14_4825, and STM_5184) that has compelling potential to be exploited as vaccine development and/or drug target to curb the Salmonella infection.
Malaysia’s Palm Oil Export to India

India is the second-most populous country after China, with an overall population exceeding 1.3 billion. India is the fifth country in the world with the highest import and consumption of world oils and fats. Palm oil has become the main of oil and fats product that is being imported and consumed in India market. India is the major of Malaysia’s palm oil export destination. Malaysia’s palm oil exports to India market continually increases since the last ten years with an average of more than 2 million tonnes a year. This study attempts to analyse factors that influence the export demand of Malaysia’s palm oil to India market. The study applies the ARDL approach for data from the period 1975 – 2018. The study indicates that there are relationships between variables in the short run and long run for the demand of palm oil exports by India. The most significant determinant is attributed to soya bean prices (LPSBR) and population (LPOPI) in both short-run and long run. The export price of palm oil by Indonesia (LCPOPXIR) indicates a positive and significant relationship as Malaysia and Indonesia are competing to penetrate to India market in the long run. However, Malaysia’s export price of palm oil has a negative relationship but insignificant. Thus, the findings suggest for non-price strategies in order to increase exports to India market. Non-price strategies such as an increase of quality and the differentiation of product as well as trade deals are the strategies to increase competitiveness and preferences of Malaysia’s palm oil in India market.
Agrochemicals, archaeology, green chemistry & water

1. Fluoride Removal from Water Using Adsorption Technique (M.S. Onyango, Hitoki Matsuda). 2. Water Defluoridation Processes: a Review - Application on Nanofiltration for Future Large Scale Pilot Plants (M. Pontie). 3. Calixpyrrole-Fluoride Interactions: from Fundamental Research to Applications in the Environmental Field (A.F. Danil de Namor, I. Abbas). 4. Fluorine-Containing Agrochemicals. An Overview of Recent Developments (Georges Theodoridis). 5. Fluorine: Friend or Foe? A Green Chemists Perspective (S.J. Tavener, J.H. Clark). 6. Emerging "Greener" Synthetic Routes to Hydrofluorocarbons: Metal Fluoride Mediated Oxyfluorination (M. Subramanian, T.G. Calvarese). 7. Fluorine Analysis by Ion Beam Techniques for Dating Applications (M. Dobeli et al.). 8. Fluorine and Its Relevance for Archaeological Studies (I. Reiche).
NMR RELAXATION METHODS TO DETECT PROTEIN DYNAMICS: EVALUATION OF ACCURACY, IMPROVEMENT OF THE METHODOLOGY, AND ITS APPLICATION

Proteins are dynamic molecules whose ability to undergo conformational changes and fluctuations can impact their biological function, such as enzyme catalysis and substrate recognition. Mutations or perturbations that do not significantly change protein structure can often have a significant effect on the function by disrupting important internal motions and conformational states. Due to the importance of protein dynamics on function, dynamics have been extensively studied by many different biophysical methods as well as computational means. One of the methods to characterize protein dynamics is by nuclear magnetic resonance (NMR) spectroscopy. NMR spectroscopy is a powerful tool for the characterization of the structure as well as the dynamics of biological molecules. In particular, NMR relaxation experiments have been used to characterize protein motion in a wide range of timescales ranging from sub-nano second (ns) motions up to millisecond (ms) and above. Recent advances in instrumentation, such as the introduction of commercially available cryogenic probes and higher field static magnets (with 1H Larmor frequency of 900 MHz and above), have increased the sensitivity of NMR experiments. However, reevaluation of the methods used in NMR relaxation experiments and the analysis of the data is required to confirm whether the same experimental methods remain valid for the improved instrumentation. In this thesis, the NMR relaxation experiments were evaluated and improvements in the experimental aspects and the analysis of the NMR relaxation data are made for high resolution NMR experiments. In addition, NMR relaxation experiments were used to investigate the dynamics of the Sarcoplasmic Reticulum Ca2+ ATPase and the Human Immunodeficiency Virus Type 1 Protease wild-type (WT) and mutant forms.
Resorcinol/formaldehyde foam shell targets for ICF

Resorcinol/formaldehyde (R/F) low-density foam making processes have been adapted to microencapsulation techniques. This has been done in an effort to make low density, low Z, transparent foam shells for use as cryogenic ICF targets. It was necessary to modify the normal R/F formulation and processing to accelerate the gelation time from tens of hours to less than one hour. Proper selection of the inner and outer oil phase solvents was critical for density matching and prevention of the dehydration of the gelling preform, respectively. 12 refs., 5 figs., 1 tab.
Binaural sound rendering improves immersion in a daily usage of a smartphone video game

Binaural rendering is a technology that could be advan-tageously coupled with a smartphone application, but is still not commonly used. The aim of this study is to investigate how this technology could enrich the experience of a video game application delivered on a smartphone, in terms of immersion, memorization and performance. We have used a longitudinal research procedure, the Experience Sampling Method, asking individuals to accomplish short game sessions in their daily life. With this procedure, we want to determine if a signiﬁcant effect of bin-aural rendering can be detected while data are noised by realistic contextual variations. The results indicate a better feeling of immersion during the binaural sessions, but no improvement was shown for memorization and performance. However, as the experiment is deployed in realistic contexts of use, this result justiﬁes the implementation of a binaural rendering in smartphone applications.
Fast detection of differential chromatin domains with SCIDDO

The generation of genome-wide maps of histone modifications using chromatin immunoprecipitation sequencing (ChIP-seq) is a common approach to dissect the complexity of the epigenome. However, interpretation and differential analysis of histone ChIP-seq datasets remains challenging due to the genomic co-occurrence of several marks and their difference in genomic spread. Here we present SCIDDO, a fast statistical method for the detection of differential chromatin domains (DCDs) from chromatin state maps. DCD detection simplifies relevant tasks such as the characterization of chromatin changes in differentially expressed genes or the examination of chromatin dynamics at regulatory elements. SCIDDO is available at github.com/ptrebert/sciddo