Miracle-dz/UniFAR-FTUs huggingface dataset:
In Vitro Biofilm Formation on Aryl Ketone Polymer (AKP), A New Denture Material, Compared with That on Three Traditional Dental Denture Materials

Control of denture plaque biofilms is a practical approach to preventing persistent oral infections such as denture stomatitis. Objectives. This study compared in vitro biofilm attachment and growth on a new denture material, Ultaire® AKP, with that on traditional denture materials including cobalt chrome (CoCr), polymethyl methacrylate (PMMA), and polyoxymethylene (POM). Methods. Microbial biofilms were grown with cultures of Candida albicans, Streptococcus mutans UA159, or a mixed Streptococcus spp. (S. mutans 700610/Streptococcus sanguinis BAA-1455) for 6 hours in a static protocol or 24 hours in a dynamic protocol for each material. Adherent biofilm cells were removed, and viable colony-forming units (CFUs) were enumerated. Confocal microscopy of the 24-hour Streptococcus spp. biofilms was used to determine biofilm mass and roughness coefficients. Results. The rank order of C. albicans attachment after 6 hours was CoCr > PMMA∗ > Ultaire® AKP∗ (∗vs CoCr, p ≤ 0.05), and that for 24-hour biofilm growth was CoCr > Ultaire® AKP∗ > PMMA∗ (∗vs CoCr, p ≤ 0.05). The rank order of S. mutans biofilm attachment was CoCr > POM > Ultaire® AKP∗ > PMMA∗ (∗vs CoCr, p ≤ 0.05), and that for the 24-hour Streptococcus spp. biofilm growth was POM > Ultaire® AKP > PMMA > CoCr∗ (∗vs POM, p ≤ 0.05). Confocal images revealed structural differences in Streptococcus spp. biofilms on CoCr compared with the other test materials. Significantly lower roughness coefficients of Streptococcus spp. biofilms on Ultaire® AKP were noted, suggesting that these biofilms were less differentiated. Ultaire® AKP promoted significantly less C. albicans and S. mutans biofilm attachment than CoCr at 6 hours and C. albicans growth at 24 hours. Streptococcus spp. biofilms on Ultaire® AKP were less differentiated than those on other test materials. Conclusion. In addition to its material strength, Ultaire® AKP represents an attractive option for denture material in removable partial dentures.
Comprehensive analysis of the circadian nuclear and cytoplasmic transcriptome in mouse liver

In eukaryotes, RNA is synthesised in the nucleus, spliced, and exported to the cytoplasm where it is translated and finally degraded. Any of these steps could be subject to temporal regulation during the circadian cycle, resulting in daily fluctuations of RNA accumulation and affecting the distribution of transcripts in different subcellular compartments. Our study analysed the nuclear and cytoplasmic, poly(A) and total transcriptomes of mouse livers collected over the course of a day. These data provide a genome-wide temporal inventory of enrichment in subcellular RNA, and revealed specific signatures of splicing, nuclear export and cytoplasmic mRNA stability related to transcript and gene lengths. Combined with a mathematical model describing rhythmic RNA profiles, we could test the rhythmicity of export rates and cytoplasmic degradation rates of approximately 1400 genes. With nuclear export times usually much shorter than cytoplasmic half-lives, we found that nuclear export contributes to the modulation and generation of rhythmic profiles of 10% of the cycling nuclear mRNAs. This study contributes to a better understanding of the dynamic regulation of the transcriptome during the day-night cycle.
Symmetry Detection and Analysis of Chinese Paifang Using 3D Point Clouds

The Chinese paifang is an essential constituent element for Chinese or many other oriental architectures. In this paper, a new method for detection and analysis of the reflection symmetry of the paifang based on 3D point clouds is proposed. The method invokes a new model to simultaneously fit two vertical planes of symmetry to the 3D point cloud of a paifang to support further symmetry analysis. Several simulated datasets were used to verify the proposed method. The results indicated that the proposed method was able to quantity the symmetry of a paifang in terms of the RMSE obtained from the ICP algorithm, with resistance to the presence of some random noise added to the simulated measurements. For real datasets, three old Chinese paifangs (with ages from 90 to 500 years) were scanned as point clouds to input into the proposed method. The method quantified the degree of symmetry for the three Chinese paifangs in terms of the RMSE, which ranged from 20 to 61 mm. One of the paifangs with apparent asymmetry had the highest RMSE (61 mm). Other than the quantification of the symmetry of the paifangs, the proposed method could also locate which portion of the paifang was relatively more symmetric. The proposed method can potentially be used for structural health inspection and cultural studies of the Chinese paifangs and some other similar architecture.
Publishing, identifiers & metrics: Playing the numbers game

The number of scientific articles published each year is rapidly growing and so is the number of academic journals. This makes it impossible for an individual practitioner or researcher to keep track of all research published in their own field or sub-discipline. With the growing amount of publications, it is also becoming more difficult to distinguish between similar papers published on the same topic, in the same journal, or by the same researchers (or research team). This perspective paper could support students and novice researchers, outlines the difference between the unique identifier for: (1) you as the researcher, (2) a specific paper; and (3) a specific journal. This paper further outlines the various numerical identifiers associated with academic publishing to help demystify academic publishing.
A narrative review of the unprofessional behaviors of physicians at workplace

Introduction: To become an ethical physician and a good professional is the fundamental duty of a doctor. The complaints regarding medical professional behaviors are usually related to doctor practice management, doctor’s manner, medical reports/records, and inappropriate behavior.Objective: This review aims to see the concerning unprofessional behaviors and unethical conduct of physicians toward patients. The literature was reviewed to identify the common unprofessional behaviors among doctors.Methods: A Narrative review was done, and databases explored were PubMed, Google Scholar, PsycINFO, Science direct, ERIC & Pak Medinet. A literature search was done regarding unprofessional behaviors by doctors at the workplace. Selected studies related to professional ethics, unprofessional workplace behaviors by doctors, professionalism, and patient experiences during their treatment were identified.Results: Various items reported as unprofessional behaviors were identified and are classified into five themes: dishonesty, substandardpractice, unethical behavior, disrespect & behaviors related to doctor manners.Conclusion: Unprofessional behaviors are reported in different health care settings. Professionalism holds a central position to fulfillthe expectations of the patients and for addressing disrespectful behaviors. KEYWORDS: Unprofessional behaviors, Workplace, Physicians
Mapping of Freshwater Snails’ Habitat—A Source of Transmitting Bilharzia in Mwea Sub-County, Kenya

Bilharzia is vector-borne disease carried by a parasite that is hosted by fresh water snails. The distribution of the disease is concurrent with the existence of the freshwater snails and is dependent on certain suitable environmental conditions. It is difficult to identify the specific habitats of the snails as they are often inaccessible on the ground, the snails also migrate by means of flowing water, making it difficult to keep a track of the freshwater snails’ habitat. This paper aimed at using GIS, Remote Sensing and Species Distribution Modelling techniques to model the suitable habitats for the freshwater snails and to prove that the snails migrate when there are sudden changes in water levels whilst showing the population at risk of bilharzia. The SDM used is the Maximum Entropy (MAXENT) for its ability to make right predictions even with small presence sites. The AUC value of the model was 0.951. The research results showed that the environmental variables; brightness Index, elevation, temperatures were negatively correlated with the snails’ presence while the wetness index, MSAVI, greenness index and soil pH were positively correlated. The snails are observed to favor clay soils of the montmorillonite type and the crop-lands land cover. Areas consistently submerged by water especially after flooding are shown to be the most suitable areas where snails migrate by means of river or canal water. The research proves that Mwea is not the source habitat of the freshwater snails. The neighboring sub-counties within Kirinyaga County should be investigated using such models as a likely source-habitat of the freshwater snails. Destroying the source habitats will lead to complete eradication of the freshwater snails within Mwea.
Transposable Elements Continuously Remodel the Regulatory Landscape, Transcriptome, and Function of Decidual Stromal Cells

Gene expression evolution underlies the origin, divergence, and conservation of biological characters including cell-types, tissues, and organ systems. Previously we showed that large-scale gene expression changes in decidual stromal cells contributed to the origins of pregnancy in eutherians and the divergence of pregnancy traits in primates, and that transposable elements likely contributed to these gene expression changes. Here we show that two large waves of TEs remodeled the transcriptome and regulatory landscape of decidual stromal cells, including a major wave in primates. Genes nearby TE-derived regulatory elements are among the most progesterone responsive in the genome and play essential roles in orchestrating progesterone responsiveness and the core function of decidual cells by donating progesterone receptor binding sites to the genome. We tested the regulatory abilities of 89 TE consensus sequences and found nearly all acted as repressors in mammalian cells, but treatment with a histone deacetylase inhibitor unmasked latent enhancer functions. These data indicate TEs have played an important role in the development, evolution, and function of primate decidual stromal cells and suggest a two-step model in which latent enhancer functions of TEs are unmasked after they lose primary repressors functions. Significance statement Gene expression patterns evolved very rapidly during the evolutionary origins of pregnancy in early mammals and in primates. These episodes of gene expression evolution and linked with important processes that establish and maintain pregnancy, and appear to be driven by domestication of transposable elements.
Stress distribution in crown and root dentin associated with different crown materials and thicknesses

Purpose: To evaluate stress distribution around the marginal area of three full veneer crown restorations with different thicknesses. Materials and Methods: Two types of premolar finite element model (normal and half thickness of crown; NC, HC) were made on the personal computer and three types of crown material (polyetheretherketone, PEEK, PK; hybrid composite resin, HR; and Ag-Pd-Cu-Au alloy, PD) were assumed. Then the magnitude of stress at the marginal area of crown was calculated. Results: The magnitude of stress for PD-NC, HR-NC, PK-NC, PD-HC, HR-HC, PK-HC was 26.4, 21.3, 14.2, 50.6, 26.1, and 13.3 MPa respectively. The crown fabricated by PEEK prevented the stress concentration at the marginal area. Conclusion: Crowns fabricated by PEEK prevent the concentration of stress at the crown margin, and there is a possibility that these crowns require less tooth preparation in this area, when compared to metallic crowns. (Asian Pac J Dent 2019; 19: 71-76.)
Urbanization alters interactions between Darwin's finches and Tribulus cistoides on the Galápagos Islands

Abstract Emerging evidence suggests that humans shape the ecology and evolution of species interactions. Islands are particularly susceptible to anthropogenic disturbance due to the fragility of their ecosystems; however, we know little about the susceptibility of species interactions to urbanization on islands. To address this gap, we studied how the earliest stages of urban development affect interactions between Darwin's finches and its key food resource, Tribulus cistoides, in three towns on the Galápagos Islands. We measured variation in mericarp predation rates, mericarp morphology, and finch community composition using population surveys, experimental manipulations, and finch observations conducted in habitats within and outside of each town. We found that both seed and mericarp removal rates were higher in towns than natural habitats. We also found that selection on mericarp size and defense differed between habitats in the survey and experimental populations and that towns supported smaller and less diverse finch communities than natural habitats. Together, our results suggest that even moderate levels of urbanization can alter ecological interactions between Darwin's finches and T. cistoides, leading to modified natural selection on T. cistoides populations. Our study demonstrates that trophic interactions on islands may be susceptible to the anthropogenic disturbance associated with urbanization. Despite containing the highest diversity in the world, studies of urbanization are lacking from the tropics. Our study identified signatures of urbanization on species interactions in a tropical island ecosystem and suggests that changes to the ecology of species interactions has the potential to alter evolution in urban environments.
Post-operative Pain and Antibacterial Efficacy of Silver Nanoparticles Formulations Intracanal Medication: A Randomized Controlled Clinical Study

AIM: To evaluate the effect of using combined calcium hydroxide/silver nanoparticles or silver nanoparticles (AgNPs) or calcium hydroxide (Ca(OH)2) individually as intracanal medications in reducing postoperative pain and intracanal bacterial count. MATERIALS AND METHODS: Thirty patients with necrotic mandibular anterior teeth were randomly divided into 3 groups; Ca(OH)2 + AgNPs or AgNPs gel (Intervention Groups) or Ca(OH)2 (Control Group). Patients received a standard 2-visit endodontic treatment and recorded their pain levels after 4, 24, 48, 72 and 96 hours following the first and second visit on a modified visual analogue scale (VAS). Intracanal bacterial counts were assessed using culturing before and after instrumentation and intracanal medication. Outcome data were statistically analyzed using Kruskal-Wallis and Fisher’s Exact tests to compare between the groups and Friedman’s test to assess the changes by time. RESULTS: At 24 hours interappointment the incidence of pain was statistically significant (P = .005) as well as at 48 hours (P = .001). There was a statistically significant difference between the mean percentage reduction of anaerobic bacterial counts in the three groups with the highest percentage in the Ca(OH)2 + AgNPs group at 98.9% followed by AgNPs group 98.5% and Ca(OH)2 at 85.3% (P <0.001). CONCLUSIONS: Combined calcium hydroxide/silver nanoparticles reduced the intracanal bacterial counts significantly, but adversely affected the interappointment pain. Based on that finding, this combination should be tested in different concentrations with different ratios to reach the most effective combination that reduce pain with high antibacterial efficacy.
Reliability Evaluation of Lithium-Ion Batteries for E-Mobility Applications from Practical and Technical Perspectives: A Case Study

Evaluation of the reliability of the components of electric vehicles (EVs) has been studied by international research centers, industry, and original equipment manufacturers over the last few years. Li-ion batteries are the main sensitive component of an EV’s E-power train. In other words, the Li-ion batteries for electromobility applications are one of the main components of an EV, which should be reliable and safe over the operational lifetime of the EV. Thus, investigating how to assess the reliability of the Li-ion battery has been a highly recommended task in most European projects. Moreover, with the increase in the number of new EVs made by European car companies, there has been a competition for market acquisition by these companies to win over customers and gain more market share. This article presents a comprehensive overview of the evaluation of the reliability of Li-ion batteries from practical and technical perspectives. Moreover, a case study for assessing reliability from practical and technical perspectives has been investigated.
Anthropometric Parameters, Lower Limb Functionality and Quality of Life After High-Intensity Interval Training in Healthy Young People Versus Older Adults

The aim of this study was to determine the effects of High-intensity interval training (HIIT) on the quality of life in healthy young people (YNG) and older adults (OLD)and its correlation with physical health status (anthropometric parameters and low r limb functionality) YNG (21 ± 2 years, BMI 26.37 ± 2.69 n = 12) and OLD (67 ± 5 years, BMI 27.16 ± 3.04 n = 12) groups underwent 12weeks of HIIT. Before and after the HIIT, anthropometric assessments, lower limb functionality tests,and SF-36 quality-of-lif e questionnaire were performed. There were no significant changes in the SF-36 dimensions (P>0.05). After HIIT, there were improvement percenta ge changes in Mental Component Summary (MCS) (YNG, +8.51 ± 25.80 % vs. OLD, +2.30 ± 9.05 %) and in Physical Component Summary (PCS) (YNG, +2.66 ± 20.54 % vs. OLD, +4.34 ± 22.71 %). Negative correlations were observed between body mass index (BMI) with PCS (R=-0.570, P=0.009) and with MCS (R=-0.649, P=0.002) in OLD as well as between MCS and waist circumference (R=-0.557, P ≤0.001) in both groups. Also, correlations were observed between PCS and the sit-to-stand test (R=-0.424, P=0.006) in both groups and g ait s eed (R=0.458, P=0.042) only in YNG. HIIT promotes positive percentage changes in quality of life, with YNG showing better results i n PCS and OLD in MCS. Quality of life and physical health status were correlated in both groups.
The Use of Tocilizumab in Patients with COVID-19: A Systematic Review, Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Studies

Background: Among the several therapeutic options assessed for the treatment of coronavirus disease 2019 (COVID-19), tocilizumab (TCZ), an antagonist of the interleukine-6 receptor, has emerged as a promising therapeutic choice, especially for the severe form of the disease. Proper synthesis of the available randomized clinical trials (RCTs) is needed to inform clinical practice. Methods: A systematic review with a meta-analysis of RCTs investigating the efficacy of TCZ in COVID-19 patients was conducted. PubMed, EMBASE, and the Cochrane COVID-19 Study Register were searched up until 30 April 2021. Results: The database search yielded 2885 records; 11 studies were considered eligible for full-text review, and nine met the inclusion criteria. Overall, 3358 patients composed the TCZ arm, and 3131 the comparator group. The main outcome was all-cause mortality at 28–30 days. Subgroup analyses according to trials’ and patients’ features were performed. A trial sequential analysis (TSA) was also carried out to minimize type I and type II errors. According to the fixed-effect model approach, TCZ was associated with a better survival odds ratio (OR) (0.84; 95% confidence interval (CI): 0.75–0.94; I2: 24% (low heterogeneity)). The result was consistent in the subgroup of severe disease (OR: 0.83; 95% CI: 0.74–0.93; I2: 53% (moderate heterogeneity)). However, the TSA illustrated that the required information size was not met unless the study that was the major source of heterogeneity was omitted. Conclusions: TCZ may represent an important weapon against severe COVID-19. Further studies are needed to consolidate this finding.
Effects of 12 Months of Vitamin D Supplementation on Physical Fitness Levels in Postmenopausal Women with Type 2 Diabetes

Introduction: It is common for postmenopausal women to receive a vitamin D supplementation prescription to assist in preventing future falls and to maintain bone health. However, the association between vitamin D supplementation and physical fitness components has not been studied in older women with diabetes. Objective: We examined the influence of 12 months of vitamin D supplementation on the components of physical fitness in postmenopausal women with type 2 diabetes mellitus (T2DM). Methods: Thirty-five postmenopausal women (62.48 ± 7.67 years; 154.6 ± 5.11 cm; 73.93 ± 15.43 kg; 31.13 ± 5.82 BMI) with a diagnosis of T2DM participated in this longitudinal study where participants were supplemented with 1000 IU/day of vitamin D over 12 months. Subjects performed fasting blood samples, anthropometric assessments, body composition, clinical exams, and physical tests at 6-month intervals (P0, P6, and P12). Results and Conclusion: Vitamin D supplementation alone was effective in postmenopausal women in increasing serum vitamin D levels, altering muscle strength levels, promoting improvements in muscle function, as well as preventing and controlling fragility caused by T2DM and aging.
THE EROSION IN EUROPEAN MANUFACTURING

The competitiveness of Western European manufacturing is slowly being eroded away and European firms must act decisively to halt this decline. Costs in Europe are high and getting higher. Productivity is not keeping pace. European manufacturers have adopted some of the ideas that have proved useful to manufacturers elsewhere around the globe, but they need to do more. Many European countries remain net exporters of direct investment. If the erosion is to be halted, European manufacturers must address overcapacity, particularly among the many small factories there, inappropriate plant locations, and company organizations that foster too much country‐specific independence.
Reppin’ and Risin’ Above: Exploring Communities of Possibility That Affirm the College-Going Aspirations of Black Youth

This case study examines how relationships with staff in a GEAR-UP (Gaining Early Awareness and Readiness for Undergraduate Programs) pre-college program positively influenced the college-going aspirations of Black ninth-grade students. Critical Race Theory and Possible Selves provide an intersecting analytical framework for understanding the formation of students’ college-going aspirations. Findings speak to how the role of student leaders in the program assisted high school students in forming college-going counternarratives and provided possible buffers to stereotype threats about what is academically possible for Black youth. In addition, findings demonstrate how the GEAR-UP program served as what I have conceptualized as an educational “Community of Possibility. ”
Information Hiding Based on Audio Steganography using Least Significant Bit

Steganography is the idea of hiding private or sensitive data or information within something that appears to be nothing out of the normal. A few problems arise especially in securing data and information when the information had been lost or stolen from unauthorized user. Traditionally, we give information manually using paper; it is possible that the information could be stolen by unauthorized user. The main objective of this study is to hide secret information in audio, so that other persons will not notice the presence of the information. The proposed method of this study is by using Least Significant Bit (LSB) algorithm to design an audio steganography. In the proposed method, each audio sample is converted into bits and then the text data is embedded. The expected result of this study will produce a steganography audio that will be able to hide data or information efficiently from unauthorized user, also to ensure the safety of the information in an authorized hand.