Miracle-dz/UniFAR-FTUs huggingface dataset:
Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery

Alpha-synuclein positive-intracytoplasmic inclusions are the common denominators of the synucleinopathies present as Lewy bodies in Parkinson’s disease, dementia with Lewy bodies, or glial cytoplasmic inclusions in multiple system atrophy. These neurodegenerative diseases also exhibit cellular dyshomeostasis, such as autophagy impairment. Several decades of research have questioned the potential link between the autophagy machinery and alpha-synuclein protein toxicity in synucleinopathy and neurodegenerative processes. Here, we aimed to discuss the active participation of autophagy impairment in alpha-synuclein accumulation and propagation, as well as alpha-synuclein-independent neurodegenerative processes in the field of synucleinopathy. Therapeutic approaches targeting the restoration of autophagy have started to emerge as relevant strategies to reverse pathological features in synucleinopathies.
Health-related quality of life of Brazilian children and adolescents with benign and malignant solid tumours: A prospective cohort study during the first year after hospital admission.

INTRODUCTION This study aims to assess the impact of paediatric benign and malignant solid tumours and its treatment on the health-related quality of life of children and adolescents who were followed up in a Reference Center in Pediatric Oncology in Rio de Janeiro. METHODS It is a prospective cohort study. Quality of life assessment was performed using the PedsQL™ 4.0 Generic Core Scales and PedsQL™ 3.0 Cancer Module protocols three times: during hospital admission (T1), 6 months after admission (T2) and 1 year after admission (T3). RESULTS We evaluated 132 patients, 59 men and 73 women, aged 2-17 years. In PedsQL™4.0, the Emotional Functioning scale was the one with the worst scores, while the scores on the Social Functioning scale was the best. In PedsQL™ 3.0, the worst domains were Procedural Anxiety and Worry. Patients with malignant bone tumours had the worst health-related quality of life. The group who received only surgery had better results. Total scores of PedsQL™4.0 and PedsQL™ 3.0 improved between T1 and T3. CONCLUSION Children and adolescents with malignant and benign neoplasms undergo changes in quality of life as a result of the disease and treatment, but an improvement has been observed over time.
Novel Strategies for Soil-Borne Diseases: Exploiting the Microbiome and Volatile-Based Mechanisms Toward Controlling Meloidogyne-Based Disease Complexes

Under more intensified cropping conditions agriculture will face increasing incidences of soil-borne plant pests and pathogens, leading to increasingly higher yield losses world-wide. Soil-borne disease complexes, in particular, are especially difficult to control. In order to better understand soil-borne Meloidogyne-based disease complexes, we studied the volatile-based control mechanism of associated bacteria as well as the rhizospheric microbiome on Ugandan tomato plants presenting different levels of root-galling damage, using a multiphasic approach. The experimental design was based on representative samplings of healthy and infected tomato plants from two field locations in Uganda, to establish species collections and DNA libraries. Root galling symptoms on tomato resulted from a multispecies infection of root-knot nematodes (Meloidogyne spp.). Results revealed that 16.5% of the bacterial strain collection produced nematicidal volatile organic compounds (nVOC) active against Meloidogyne. Using SPME GC-MS, diverse VOC were identified, including sulfuric compounds, alkenes and one pyrazine. Around 28% of the bacterial strains were also antagonistic toward at least one fungal pathogen of the disease complex. However, antagonistic interactions appear highly specific. Nematicidal antagonists included Pseudomonas, Comamonas, and Variovorax and fungicidal antagonists belonged to Bacillus, which interestingly, were primarily recovered from healthy roots, while nematode antagonists were prominent in the rhizosphere and roots of diseased roots. In summary, all antagonists comprised up to 6.4% of the tomato root microbiota. In general, the microbiota of healthy and diseased root endospheres differed significantly in alpha and quantitative beta diversity indices. Bacteria-derived volatiles appear to provide a remarkable, yet wholly unexploited, potential to control Meloidogyne-based soil-borne disease complexes. The highly specific observed antagonism indicates that a combination of volatiles or VOC-producing bacteria are necessary to counter the range of pathogens involved in such complexes.
Maximally rotating supermassive stars at the onset of collapse: effects of gas pressure

The ‘direct collapse’ scenario has emerged as a promising evolutionary track for the formation of supermassive black holes early in the Universe. In an idealized version of such a scenario, a uniformly rotating supermassive star spinning at the mass-shedding (Keplerian) limit collapses gravitationally after it reaches a critical configuration. Under the assumption that the gas is dominated by radiation pressure, this critical configuration is characterized by unique values of the dimensionless parameters J/M2 and Rp/M, where J is the angular momentum, Rp the polar radius, and M the mass. Motivated by a previous perturbative treatment, we adopt a fully non-linear approach to evaluate the effects of gas pressure on these dimensionless parameters for a large range of masses. We find that gas pressure has a significant effect on the critical configuration even for stellar masses as large as $M \simeq 10^6 \, \mathrm{M}_{\odot }$. We also calibrate two approximate treatments of the gas pressure perturbation in a comparison with the exact treatment, and find that one commonly used approximation in particular results in increasing deviations from the exact treatment as the mass decreases, and the effects of gas pressure increase. The other approximation, however, proves to be quite robust for all masses $M \gtrsim 10^4 \, \mathrm{M}_{\odot }$.
Community Treatment Orders and Supported Decision-Making

This paper presents findings from an interdisciplinary project undertaken in Victoria, Australia, investigating the barriers and facilitators to supported decision-making (SDM) for people living with diagnoses including schizophrenia, psychosis, bipolar disorder, and severe depression; family members supporting them; and mental health practitioners, including psychiatrists. We considered how SDM can be used to align Australian laws and practice with international human rights obligations. The project examined the experiences, views, and preferences of consumers of mental health services, including people with experiences of being on Community Treatment Orders (CTOs), in relation to enabling SDM in mental health service delivery. It also examined the perspectives of informal family members or carers and mental health practitioners. Victoria currently has high rates of use of CTOs, and the emphasis on SDM in the Mental Health Act, 2014, is proposed as one method for reducing coercion within the mental health system and working towards more recovery-oriented practice. Our findings cautiously suggest that SDM may contribute to reducing the use of CTOs, encouraging less use of coercive practices, and improving the experience of people who are subject to these orders, through greater respect for their views and preferences. Nonetheless, the participants in our study expressed an often ambivalent stance towards CTOs. In particular, the emphasis on medication as the primary treatment option and the limited communication about distressing side effects, alongside lack of choice of medication, was a primary source of concern. Fears, particularly among staff, about the risk of harm to self and others, and stigma attached to complex mental health conditions experienced by consumers and their families, represent important overarching concerns in the implementation of CTOs. Supporting the decision-making of people on CTOs, respecting their views and preferences about treatment, and moving towards reducing the use of CTOs require system-wide transformation and a significant shift in values and practice across mental health service delivery.
Psychological and Cognitive Markers of Behavioral Variant Frontotemporal Dementia–A Clinical Neuropsychologist's View on Diagnostic Criteria and Beyond

Behavioral variant frontotemporal dementia (bvFTD) is the second leading cognitive disorder caused by neurodegeneration in patients under 65 years of age. Characterized by frontal, insular, and/or temporal brain atrophy, patients present with heterogeneous constellations of behavioral and psychological symptoms among which progressive changes in social conduct, lack of empathy, apathy, disinhibited behaviors, and cognitive impairments are frequently observed. Since the histopathology of the disease is heterogeneous and identified genetic mutations only account for ~30% of cases, there are no reliable biomarkers for the diagnosis of bvFTD available in clinical routine as yet. Early detection of bvFTD thus relies on correct application of clinical diagnostic criteria. Their evaluation however, requires expertise and in-depth assessments of cognitive functions, history taking, clinical observations as well as caregiver reports on behavioral and psychological symptoms and their respective changes. With this review, we aim for a critical appraisal of common methods to access the behavioral and psychological symptoms as well as the cognitive alterations presented in the diagnostic criteria for bvFTD. We highlight both, practical difficulties as well as current controversies regarding an overlap of symptoms and particularly cognitive impairments with other neurodegenerative and primary psychiatric diseases. We then review more recent developments and evidence on cognitive, behavioral and psychological symptoms of bvFTD beyond the diagnostic criteria which may prospectively enhance the early detection and differential diagnosis in clinical routine. In particular, evidence on specific impairments in social and emotional processing, praxis abilities as well as interoceptive processing in bvFTD is summarized and potential links with behavior and classic cognitive domains are discussed. We finally outline both, future opportunities and major challenges with regard to the role of clinical neuropsychology in detecting bvFTD and related neurocognitive disorders.
Inter-sentence Relation Extraction with Document-level Graph Convolutional Neural Network

Inter-sentence relation extraction deals with a number of complex semantic relationships in documents, which require local, non-local, syntactic and semantic dependencies. Existing methods do not fully exploit such dependencies. We present a novel inter-sentence relation extraction model that builds a labelled edge graph convolutional neural network model on a document-level graph. The graph is constructed using various inter- and intra-sentence dependencies to capture local and non-local dependency information. In order to predict the relation of an entity pair, we utilise multi-instance learning with bi-affine pairwise scoring. Experimental results show that our model achieves comparable performance to the state-of-the-art neural models on two biochemistry datasets. Our analysis shows that all the types in the graph are effective for inter-sentence relation extraction.
High-Yield Production of 4-Hydroxybenzoate From Glucose or Glycerol by an Engineered Pseudomonas taiwanensis VLB120

Aromatic compounds such as 4-hydroxybenzoic acid are broadly applied in industry for a myriad of applications used in everyday life. However, their industrial production currently relies heavily on fossil resources and involves environmentally unfriendly production conditions, thus creating the need for more sustainable biotechnological alternatives. In this study, synthetic biology was applied to metabolically engineer Pseudomonas taiwanensis VLB120 to produce 4-hydroxybenzoate from glucose, xylose, or glycerol as sole carbon sources. Genes encoding a 4-hydroxybenzoate production pathway were integrated into the host genome and the flux toward the central precursor tyrosine was enhanced by overexpressing genes encoding key enzymes of the shikimate pathway. The flux toward tryptophan biosynthesis was decreased by introducing a P290S point mutation in the trpE gene, and degradation pathways for 4-hydroxybenzoate, 4-hydroxyphenylpyruvate and 3-dehydroshikimate were knocked out. The resulting production strains were tailored for the utilization of glucose and glycerol through the rational modification of central carbon metabolism. In batch cultivations with a completely mineral medium, the best strain produced 1.37 mM 4-hydroxybenzoate from xylose with a C-mol yield of 8% and 3.3 mM from glucose with a C-mol yield of 19.0%. Using glycerol as a sole carbon source, the C-mol yield increased to 29.6%. To our knowledge, this is the highest yield achieved by any species in a fully mineral medium. In all, the efficient conversion of bio-based substrates into 4-hydroxybenzoate by these deeply engineered P. taiwanensis strains brings the renewable production of aromatics one step closer.
Tropical cyclogenesis in wind shear: Climatological relationships and physical processes

The formation of tropical cyclones remains a topic of great interest in the field of tropical meteorology. A number of influential studies have considered the process of tropical cyclone formation (also known as TC genesis) from a pre-existing, weak tropical disturbance in a quiescent atmosphere from theoretical perspectives and using numerical simulations. However, it is shown that the large majority of TC genesis events occur under the influence of significant vertical wind shear. The effects of wind shear on TC genesis is explored from both a climatological perspective and from the statistics of wind shear in environments around individual TC genesis events. While earlier studies suggested that moderate wind shear values, in the range of 5 to 10 ms -1 , were the most favorable states for genesis, it is shown that small values of wind shear in the range of 1.25 to 5 ms -1 are the most favorable, and very little shear (less than 1.25 ms -1 ) is not unfavorable. Statistically, easterly shear appears to be more favorable than westerly shear. The physical process of TC genesis in wind shear is explored with high-resolution numerical simulations using a mesoscale model in an idealized framework. The transformation of a weak, mid-level vortex into a warm-cored tropical cyclone is simulated in environments with no flow, with mean flow and no wind shear, and with mean flow and wind shear. The simulations show that in terms of the formation of a closed, low-level circulation, moderate wind shear is indeed more conducive to genesis, but is also prohibitive to further development. However, in contrast to the statistical findings and some previous results, westerly shear is found to be significantly more favorable for TC genesis than easterly shear. The reasons for the greater favorableness of *E-mail address: dnolan@rsmas.miami. edu 2 David S. Nolan and Michael G. McGauley wind shear versus no wind shear, and of westerly shear versus easterly shear, are discussed within the context of the numerical simulations. Further statistical analysis suggests that the greater favorableness for easterly shear in the real atmosphere may be due to a correlation between easterly shear and more favorable thermodynamic conditions.
The Polarization-Index: A Simple Calculation to Distinguish Polarized From Non-polarized Training Intensity Distributions

The training intensity distribution (TID) of endurance athletes has retrieved substantial scientific interest since it reflects a vital component of training prescription: (i) the intensity of exercise and its distribution over time are essential components for adaptation to endurance training and (ii) the training volume (at least for most endurance disciplines) is already near or at maximum, so optimization of training procedures including TID have become paramount for success. This paper aims to elaborate the polarization-index (PI) which is calculated as log10(Zone 1/Zone 2∗Zone 3∗100), where Zones 1–3 refer to aggregated volume (time or distance) spent with low, mid, or high intensity training. PI allows to distinguish between non-polarized and polarized TID using a cut-off > 2.00 a.U. and to quantify the level of a polarized TID. Within this hypothesis paper, examples from the literature illustrating the usefulness of PI-calculation are discussed as well as its limitations. Further it is elucidated how the PI may contribute to a more precise definition of TID descriptors.
Potential Reproducibility of Potassium-Selective Electrodes Having Perfluorinated Alkanoate Side Chain Functionalized Poly(3,4-ethylenedioxytiophene) as a Hydrophobic Solid Contact

The irreproducibility of the standard potential (E°) is probably the last major challenge for the commercialization of solid-contact ion-selective electrodes (SCISEs) as single-use or wearable sensors. To overcome this issue, we are introducing for the first time a perfluorinated alkanoate side chain functionalized poly(3,4-ethylenedioxythiophene) (PEDOTF) as a hydrophobic SC in potassium-selective electrodes (K-SCISEs) based on plasticized poly(vinyl chloride). The SC incorporates the tetrakis(pentafluorophenyl)borate (TFAB–) anion, which is also present as a lipophilic additive in the ion-selective membrane (ISM), thus ensuring thermodynamic reversibility at the SC/ISM interface and improving the potential reproducibility of the electrodes. We show here that the PEDOTF-TFAB solid contact, which was prepolarized prior to the ISM deposition to either its half or fully conducting form (i.e. different oxidation states) in acetonitrile containing 0.01 M KTFAB, had a very stable open-circuit potential and an outstanding potential reproducibility of only ±0.5 mV (n = 6) for 1 h in the same solution after the prepolarization. This shows that the oxidation state of the highly hydrophobic PEDOTF-TFAB film (water contact angle 133°) is stable over time and can be precisely controlled with prepolarization. The SC was also not light sensitive, which is normally a disadvantage of conducting polymer SCs. After the ISM deposition, the standard deviation of the E° of the K-SCISEs prepared on glassy carbon was ±3.0 mV (n = 5), which is the same as that for conventional liquid contact K-ISEs. This indicates that the ISM deposition is the main source for the potential irreproducibility of the K-SCISEs, which has been overlooked previously.
Developing a Survey Tool to Assess Implementation of Evidence-Based Chronic Disease Prevention in Public Health Settings Across Four Countries

Background: Understanding the contextual factors that influence the dissemination and implementation of evidence-based chronic disease prevention (EBCDP) interventions in public health settings across countries could inform strategies to support the dissemination and implementation of EBCDP interventions globally and more effectively prevent chronic diseases. A survey tool to use across diverse countries is lacking. This study describes the development and reliability testing of a survey tool to assess the stage of dissemination, multi-level contextual factors, and individual and agency characteristics that influence the dissemination and implementation of EBCDP interventions in Australia, Brazil, China, and the United States. Methods: Development of the 26-question survey included, a narrative literature review of extant measures in EBCDP; qualitative interviews with 50 chronic disease prevention practitioners in Australia, Brazil, China, and the United States; review by an expert panel of researchers in EBCDP; and test-retest reliability assessment. Results: A convenience sample of practitioners working in chronic disease prevention in each country completed the survey twice (N = 165). Overall, this tool produced good to moderately reliable responses. Generally, reliability of responses was higher among practitioners from Australia and the United States than China and Brazil. Conclusions: Reliability findings inform the adaptation and further development of this tool. Revisions to four questions are recommended before use in China and revisions to two questions before use in Brazil. This survey tool can contribute toward an improved understanding of the contextual factors that public health practitioners in Australia, Brazil, China, and the United States face in their daily chronic disease prevention work related to the dissemination and implementation of EBCDP interventions. This understanding is necessary for the creation of multi-level strategies and policies that promote evidence-based decision-making and effective prevention of chronic diseases on a more global scale.
Self-Adaptive QoS Management of Computation and Communication Resources in Many-Core SoCs

Providing quality of service (QoS) for many-core systems with dynamic application admission is challenging due to the high amount of resources to manage and the unpredictability of computation and communication events. Related works propose a self-adaptive QoS mechanism concerned either in communication or computation resources, lacking, however, a comprehensive QoS management of both. Assuming a many-core system with QoS monitoring, runtime circuit-switching establishment, task migration, and a soft real-time task scheduler, this work fills this gap by proposing a novel self-adaptive QoS management. The contribution of this proposal comes with the following features in the QoS management: (i) comprehensiveness, by covering communication and computation resources; (ii) online, adopting the ODA (Observe, Decide, Act) runtime closed-loop adaptation; and (iii) reactive and proactive decisions, by using a dynamic application profile extraction technique, which enables the QoS management to be aware of the profile of running applications, allowing it to take proactive decisions based on a prediction analysis. The proposed QoS management adopts a decentralized organization by partitioning the system in clusters, each one managed by a dedicated processor, making the proposal scalable. Results show that the proactive feature accurately extracts the applications’ profile, and can prevent future QoS violations. The synergy of reactive and proactive decisions was able to sustain QoS, reducing the deadline miss rate by 99.5% with a severe disturbance in communication and computation levels, and avoiding deadline misses up to 70% of system utilization.