Miracle-dz/UniFAR-FTUs huggingface dataset:
Physiological Genomics of Exercise in Health and Disease Discovery and refinement of muscle weight QTLs in B 6 D 2 advanced intercross mice

Carbonetto P, Cheng R, Gyekis JP, Parker CC, Blizard DA, Palmer AA, Lionikas A. Discovery and refinement of muscle weight QTLs in B6 D2 advanced intercross mice. Physiol Genomics 46: 571–582, 2014. First published June 24, 2014; doi:10.1152/physiolgenomics.00055. 2014. —The genes underlying variation in skeletal muscle mass are poorly understood. Although many quantitative trait loci (QTLs) have been mapped in crosses of mouse strains, the limited resolution inherent in these conventional studies has made it difficult to reliably pinpoint the causal genetic variants. The accumulated recombination events in an advanced intercross line (AIL), in which mice from two inbred strains are mated at random for several generations, can improve mapping resolution. We demonstrate these advancements in mapping QTLs for hindlimb muscle weights in an AIL (n 832) of the C57BL/6J (B6) and DBA/2J (D2) strains, generations F8–F13. We mapped muscle weight QTLs using the high-density MegaMUGA SNP panel. The QTLs highlight the shared genetic architecture of four hindlimb muscles and suggest that the genetic contributions to muscle variation are substantially different in males and females, at least in the B6D2 lineage. Out of the 15 muscle weight QTLs identified in the AIL, nine overlapped the genomic regions discovered in an earlier B6D2 F2 intercross. Mapping resolution, however, was substantially improved in our study to a median QTL interval of 12.5 Mb. Subsequent sequence analysis of the QTL regions revealed 20 genes with nonsense or potentially damaging missense mutations. Further refinement of the muscle weight QTLs using additional functional information, such as gene expression differences between alleles, will be important for discerning the causal genes.
The University of Johannesburg merger: Academics experience of the pre-merger phase

Purpose of the study: The aim of this study is to gain an understanding of the merger experiences academic staff were exposed to during the pre-merger phase of the University of Johannesburg merger. Of particular interest is how these experiences translate into acceptance of the merger amongst academic staff. The study was borne out of the transformation of the higher education landscape in South Africa, which is typified by a spate of mergers between higher education institutions. Design/methodology/approach: As the purpose of the study was, inter alia, aimed at understanding the merger experiences of academic staff, the study was conducted according to an interpretive research paradigm, where interpretation of data calls for an insider perspective, in order to "see things through their eyes" as it were. In this regard, a qualitative methodology was employed. Findings: Findings indicate that academic staff members at the University of Johannesburg experience two distinct mental states during the pre-merger phase. Following the announcement of the merger, reaction and experience tend to be emotionally driven but as merging efforts become more concrete over time, this emotive state is replaced by a more rationally driven disposition. Implications: The distinction between an emotive and rational demeanour during the pre-merger phase of a merger affords managers and leaders the opportunity to plan change interventions in such a way that irrational, emotive responses and behaviour do not hamper progress in terms of merger implementation. In a more general sense, this study highlights the process of transition individual staff members pass through as they have to come to terms with the changes brought about by a merger. Originality / Value: The majority of merger literature, as well as change literature, focuses on the organisational context of change during a merger. Limited literature exists on the personal effects of a change event such as a merger. This study can thus contribute to the understanding of the personal effects of change during a merger. Furthermore, scant literature exists concerning mergers that are not driven by "conventional" economic motives. As the University of Johannesburg is this type of merger, this study presents the opportunity of gaining a better understanding of this type of merger.
Effects of salinity and plasma prolactin on chloride cells in the gill of Chalcalburnus chalcoides

Gill chloride cells and prolactin hormone are of high importance in the adaptation of euryhaline fish. Guldenstati (Chalcalburnus chalcoides, 1772), an adromous fish, migrates from the Caspian Sea to rivers to have a more successful reproduction. The present study was aimed to evaluate the changes in the number and size of C. chalcoides gill chloride cells as well as to determine the relationship of its plasma prolactin with water salinity. Eighty-four individual C. chalcoides were collected from river (Lale Roud; 0.4 ppt), Lale Roud estuary (3.75 ppt), and Caspian Sea (9.71 ppt). The sampling was lasted for a-12 month period in 2014. The highest (1349 ± 152) and lowest (881 ± 37) number of gill chloride cells were observed in the animals collected from the Caspian Sea and in the river (Lale Roud), respectively. However, plasma prolactin demonstrated the highest level in C. chalcoides caught from the river (0.89 ± 0.02 ng ml), but the lowest amount (0.70 ± 0.03 ng ml) in the ones collected from the Caspian Sea. Correspondence: A Moshfegh, Department of Biology, Lahijan Branch, Islamic Azad University, Lahijan, Iran (e-mail: moshfeghazam@gmail.Com). Overall, these results suggest that C. chalcoides migration across its habitats is an energy consuming ecological behavior, and the fish consumes high energy just after breeding and while returning to the Caspian Sea.
Estimation of the transition matrix in Markov Chain model of customer lifetime value using flower pollination algorithm

Customer Lifetime Value (CLV) is a useful and important concept in marketing to help any company in budgeting marketing cost for its customers. This paper presents a fairly new class of CLV models that is Markov Chain Models (MCM). The major advantage of this model is its flexibility to be modified to several different classification schemes. One of them is the probability transition matrix containing the rate of retention and acquisition. It plays an important role to calculate the total cost to maintain the satisfaction of a customer. In contrast, a company can set the future benefit for a certain customer. The term of this is called CLV. The aim of this paper is to estimate the matrix for a customer from the target 3410 Udjianna S. Pasaribu et al. of his expected future benefit (or CLV). Mathematically, the estimation formula contains nonlinear form of the elements of the probability transition matrix and this is called as the inverse problem of CLV. The numerical method applied in this work is a metaheuristic optimization algorithm developed by Yang, 2013, that is Flower Pollination Algorithm. For the study case, health insurance data is taken along with some arbitrary constant interest rates for the next five years.
Retrospective study of clinical complications occurring after arterial punctures in 1 1 dogs

THE risks associated with percutaneous arterial puncture in dogs are a source of anxiety for practitioners, although the procedure is recognised as a simple and useful diagnostic tool for the investigation of clinical oxygenation and acid-base disturbances (McKiernan and Johnson 1992). In human patients, previous studies have shown that the rate of complications after arterial puncture varies between almost zero (Ward and Green 1965) and 17-3 per cent (Kottke and others 1964). A serious albeit uncommon complication is thrombosis (Malley 1990). Haemorrhage or haematoma may also be a problem, particularly in patients with aortic valvular incompetence, in patients receiving anticoagulation therapy, and in patients with hypertension (Mortensen 1967, Macon and Futrell 1973, Mathieu and others 1973, Neviaser and others 1976, Malley 1990). However, there has been no detailed analysis of the clinical complications of arterial puncture in dogs, which may partly account for the hesitation of practitioners to use the procedure. The objectives of this study were to review the clinical complications of arterial puncture in 111 dogs and to analyse the factors associated with them.
COMPUTATION OF LOCAL ISS LYAPUNOV FUNCTIONS WITH LOW GAINS VIA LINEAR PROGRAMMING

In this paper, we present a numerical algorithm for computing ISS Lyapunov functions for continuous-time systems which are input-to-state stable (ISS) on compact subsets of the state space. The algorithm relies on a linear programming problem and computes a continuous piecewise ane ISS Lyapunov function on a simplicial grid covering the given compact set excluding a small neighborhood of the origin. The objective of the linear programming problem is to minimize the gain. We show that for every ISS system with a locally Lipschitz right-hand side our algorithm is in principle able to deliver an ISS Lyapunov function. For C2 right-hand sides a more ecient algorithm is proposed.
P o S ( T W E P P-1 7 ) 1 3 1 An FPGA-based Track Finder for the L 1 Trigger of the CMS Experiment at the HL-LHC

A new tracking detector is under development for use by the CMS experiment at the HighLuminosity LHC (HL-LHC). A crucial component of this upgrade will be the ability to reconstruct within a few microseconds all charged particle tracks with transverse momentum above 3 GeV, so they can be used in the Level-1 trigger decision. A concept for an FPGA-based track finder using a fully time-multiplexed architecture is presented, where track candidates are reconstructed using a projective binning algorithm based on the Hough Transform followed by a track fitting based on the linear regression technique. A hardware demonstrator using MP7 processing boards has been assembled to prove the entire system, from the output of the tracker readout boards to the reconstruction of tracks with fitted helix parameters. It successfully operates on one eighth of the tracker solid angle at a time, processing events taken at 40 MHz, each with up to 200 superimposed proton-proton interactions, whilst satisfying latency constraints. The demonstrated track-reconstruction system, the chosen architecture, the achievements to date and future options for such a system will be discussed.
PDFlib PLOP: PDF Linearization, Optimization, Protection Page inserted by evaluation version

Food allergies are IgE-mediated immunological reactions; this distinguishes them from other adverse reactions to foods. Most (>90%) of the recognized food allergies are generally thought to be caused by eight foods or food groups. A number of factors can affect food allergy development, including diet and culture, route of exposure, processing, cooking, and digestion. In addition, it is thought that the properties of certain food proteins render them more likely to be allergenic than other proteins. Most food allergens are major proteins, polyvalent molecules with at least two or more IgE-binding sites, and are recognized as foreign molecules (hence immunogenic). A number of major food allergens have been recently characterized, and amino acid sequences determined. Tropomyosin is the only major allergen of shrimp. A number of IgE-binding epitopes have been identified in this molecule, though they may vary from one shrimp-allergic individual to another. Single amino acid substitutions within epitopes based on that of homologous, nonreactive tropomyosins can substantially enhance or abolish IgE antibody binding. Using the accumulated knowledge of food allergen protein structure, the allergenicity of novel proteins to which there has been no prior human exposure has been assessed. This has been based primarily on the lability or resistance of a protein to enzymatic degradation. Clearly, further criteria must be developed to refine this process. In this regard, the development of animal models that have been sufficiently validated as surrogates of human IgE antibody responses is needed for more precise assessment of the allergenic potential of proteins.
Combinatorial Chemistry and Molecular Diversity in Drug Discovery

In this book, the author’s purpose was 2-fold: introduce intellectual property concepts and introduce strategic thinking as a tool for patent portfolio management. The chapters about basic intellectual property concepts and global filings are an excellent overview of a constantly changing environment. Basic intellectual concepts including the reason and value patents, the basic requirements for obtaining a patent, the basic parts of a patent, and the existence and meaning of various patent conventions and treaties are described. The overview acknowledges differences among the patent offices and emphasizes the use of patent agents or attorneys to help with these differences. The chapter that describes the development of a strategy begins with the need to evaluate the patentability of an invention. Once this decision is made, a strategy based on a military model is described. The strategy includes the strategy for a specific invention, a strategy for a series of inventions, and a strategy for licensing Throughout his book, the author emphasizes the need for researchers, research managers, business planners, and the intellectual property group to work together to plan and execute the strategy. The patent portfolio should be developed to be consistent with the overall research and business plans of the organization. This book is a thoughtful and informative approach to patent strategy. The author achieves his purpose to introduce intellectual property concepts and introduce a strategy for patent portfolio management in the first 100 pages. The chapters about filing procedures, post issuance strategy, and researcher characteristics could have had more information. However, the cost of the book prohibits a recommendation for personal purchase.
Assessment of Point Process Models for Earthquake Forecasting

Models for forecasting earthquakes are currently tested prospectively in well-organized testing centers, using data collected after the models and their parameters are completely specified. The extent to which these models agree with the data is typically assessed using a variety of numerical tests, which unfortunately have low power and may be misleading for model comparison purposes. Promising alternatives exist, especially residual methods such as super-thinning and Voronoi residuals. This article reviews some of these tests and residual methods for determining the goodness of fit of earthquake forecasting models.
Running head : Liver stiffness in HCV patients with SVR

been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/jgh.13788 This article is protected by copyright. All rights reserved. Original article Improvement of liver stiffness in patients with hepatitis C virus infection who received direct-acting antiviral therapy and achieved sustained virological response
3 Subjects and Consciousness

What is it to represent oneself as oneself? And what is the nature of the entity, if any, so represented? These are the two questions to be addressed in this chapter. The first is a question about the nature of intentional content; the second concerns the metaphysics of the self. We should aim for an integrated pair of answers to these questions, an integration that makes it clear why the content elucidated in answering the first question is a way of representing an entity of the sort characterized in answering the second question. In this particular area, I believe that reflection on the question about content yields some important resources for answering the second question. So I will begin with the question about content.
miR-125 a seed binding site accessibility G quadruplex RNA structures in PSD-95 mRNA : potential regulators of Material Supplemental

Fragile X syndrome (FXS) is the most common inherited form of intellectual disability caused by the CGG trinucleotide expansion in the 3′-untranslated region of the FMR1 gene on the X chromosome, that silences the expression of the Fragile X mental retardation protein (FMRP). FMRP has been shown to bind to a G-rich region within the PSD-95 mRNA which encodes for the postsynaptic density protein 95 (PSD-95), and together with the microRNA miR-125a, to play an important role in the reversible inhibition of the PSD-95 mRNA translation in neurons. The loss of FMRP in Fmr1 KO mice disables this translation control in the production of the PSD-95 protein. Interestingly, the miR-125a binding site on PSD-95 mRNA is embedded in the G-rich region bound by FMRP and postulated to adopt one or more G quadruplex structures. In this study, we have used different biophysical techniques to validate and characterize the formation of parallel G quadruplex structures and binding of miR-125a to its complementary sequence located within the 3′ UTR of PSD-95 mRNA. Our results indicate that the PSD-95 mRNA G-rich region folds into alternate G quadruplex conformations that coexist in equilibrium. miR-125a forms a stable complex with PSD-95 mRNA, as evident by characteristic Watson–Crick base-pairing that coexists with one of the G quadruplex forms, suggesting a novel mechanism for G quadruplex structures to regulate the access of miR-125a to its binding site.
The 4 th International Conference on Ambient Systems , Networks and Technologies ( ANT 2013 ) Ad-- through Rate

Click here and insert your abstract text. Search engine advertising has become one of the most important revenue models of electronic commerce. It strongly affects the probability that users click on the ads at the side of the search results page if the system shows the right ones. To maximize the outcome of search engine revenue and improve perception on those ads, it is important to understand the factors which affect the click through rate (CTR) on those ads. Tencent founded in 1998, is one of China's largest and most used Internet service portals. It provides a number of online services such as value-added Internet, mobile and telecom services and online advertising. As of September 30, 2011, Tencent had 711.7 million active Instant Messenger users. It forms the largest Internet Community in China. In this research, we use a very large dataset of Tencent click logs (soso.com) with millions records. First we describe how soso.com searching engine advertising works, our system architecture is designed with the click log dataset, and observations inside it aims at those ads with enough historical click logs. Then we show how to use ad-centric features to discover models that can find factors affecting CTR prediction performance. The proposed framework could help both optimizing the search engine system for soso.com and improving the ads designs for the advertisers. © 2011 Published by Elsevier Ltd. Selection and/or peer-review under responsibility of [name organizer]
Infant Behavior and Development he development of gaze behaviors in response to biological otion displays

Although the relationship between biological motion perception as depicted by point-light displays and social cognition has been investigated in recent decades, the developmental course of the integration of social cognition and the perception of biological motion is not well understood. To better understand this development, we investigated the ability of 9and 12-month-old infants to shift their gaze toward a point-light upright human figure using a paradigm similar to that used by Yoon and Johnson (2009). We found that 12-monthold, but not 9-month-old, infants were able to follow the direction of attention of the upright point-light figure (Experiments 1 and 2). However, both the younger and older infants were able to follow the attentional shift of others under the full-view condition (Experimental 3). These results suggest that the ability to process the higher-level information provided by biological motion patterns, such as the attentional direction of others, develops by 12 months, but not by 9 months, of age. The relationship between the development of social cognition and that of biological motion perception is discussed. © 2015 Elsevier Inc. All rights reserved.
Solid Tumors Using Molecular Inversion Probe e Based Single-Nucleotide Polymorphism Array

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 jmd.amjpathol. org 63 64 65 66 67 68 69 70 71 72 73 74 75 76 Comprehensive Screening of Gene Copy Number Aberrations in Formalin-Fixed, Paraffin-Embedded 77 78 79 80 81 82 83 84 85 Solid Tumors Using Molecular Inversion ProbeeBased Single-Nucleotide Polymorphism Array Rajesh R. Singh,* Meenakshi Mehrotra,* Hui Chen,y Alaa A. Almohammedsalim,* Ayesagul Sahin,y Alex Bosamra,y Keyur P. Patel,* Mark J. Routbort,* Xinyan Lu,y Abraham Ronald,* Bal M. Mishra,y Shumaila Virani,* L. Jeffrey Medeiros,* and Rajyalakshmi Luthra* 86 87 88 From the Departments of Hematopathology* and Pathology, y The University of Texas MD Anderson Cancer Center, Houston, Texas
Viscous-flow calculations for bare hull DARPA SUBOFF submarine at incidence

By order of the Defence Materiel Organisation (DMO) of the Royal Netherlands Navy (RNLN) the Maritime Research Institute Netherlands (MARIN) conducts studies regarding the hydrodynamics and manoeuvring capabilities of submarines. Together, they are actively involved in the Submarine Hydrodynamics Working Group (SHWG). The SHWG is a group of international navies from Australia, Canada, Germany, France, UK, USA and The Netherlands. In general, the navies team up with local research institutes. Informal meetings are held every eighteen months to discuss non-classified subjects related to hydrodynamics of submarines. Within the SHWG, a study was initiated to assess the state-of-the-art in computations of viscous flows around a submarine and to accelerate and improve research and development of numerical submarine hydrodynamics. In the study, a common testcase was defined for which each navy was asked to generate predictions based on their best approach in viscous-flow calculations. The central question in the study is to demonstrate the capability of viscous-flow solvers to reproduce the flow field around and the forces acting on a submarine hull form. This article presents the work conducted by the Dutch team.
eukaryotic alga and its DNA virus Horizontal gene transfer of an entire metabolic pathway between a Material

Material Supplemental http://genome.cshlp. org/content/suppl/2009/06/16/gr.091686. 109.DC1. html References http://genome.cshlp. org/content/19/8/1441.full. html#ref-list-1 This article cites 62 articles, 26 of which can be accessed free at: License Commons Creative http://creativecommons.org/licenses/by-nc/3.0/. described at a Creative Commons License (Attribution-NonCommercial 3.0 Unported License), as ). After six months, it is available under http://genome.cshlp. org/site/misc/terms.xhtml first six months after the full-issue publication date (see This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the