Miracle-dz/UniFAR-FTUs huggingface dataset:
Oral pathogen in the pathogenesis of colorectal cancer

The human body contains more than 100 trillion microorganisms, including the oral cavity, the skin, and the gastrointestinal tract. After the gastrointestinal tract, the oral cavity harbors one of the most diverse microbial communities within the human body and harbors more than 770 species of bacteria. The composition of the oral and gut microbiomes is quite different, but there may be a microbiological link between the two mucosal sites during the course of disease. More studies indicate that oral bacteria can disseminate to the distal gut via enteral or hematogenous routes. This is mostly obvious in periodontitis, where specific bacteria, such as Fusobacterium nucleatum and Porphyromonas gingivalis, show this pathogenic feature. The translocation of oral microbes to the gut may give rise to a variety of gastrointestinal diseases, including colorectal cancer. However, the precise role that oral microbe play in colorectal cancer has not been fully illustrated. Here, we summarize the current researches on possible pathways of ectopic gut colonization by oral bacteria and their possible contribution to the pathogenesis of colorectal cancer. Understanding the correlation of the oral‐to‐gut microbial axis in the pathogenesis of colorectal cancer will contribute to precise diagnosis and effective treatment.
Relationship between electrocardiogram‐based features and personality traits: Machine learning approach

Based on the known relationship between the human emotion and standard surface electrocardiogram (ECG), we explored the relationship between features extracted from standard ECG recorded during relaxation and seven personality traits (Honesty/humility, Emotionality, eXtraversion, Agreeableness, Conscientiousness, Openness, and Disintegration) by using the machine learning (ML) approach which learns from the ECG‐based features and predicts the appropriate personality trait by adopting an automated software algorithm.
Interaction of brassinosteroid and cytokinin promotes ovule initiation and increases seed number per silique in Arabidopsis.

Ovule initiation is a key step that strongly influences ovule number and seed yield. Notably, mutants with enhanced brassinosteroid (BR) and cytokinin (CK) signaling produce more ovules and have a higher seed number per silique (SNS) than wild-type plants. Here, we crossed BR- and CK-related mutants to test whether these phytohormones function together in ovule initiation. We determined that simultaneously enhancing BR and CK contents led to higher ovule and seed numbers than enhancing BR or CK separately, and BR and CK enhanced each other. Further, the BR-response transcription factor BZR1 directly interacted with the CK-response transcription factor ARABIDOPSIS RESPONSE REGULATOR1 (ARR1). Treatments with BR or BR plus CK strengthened this interaction and subsequent ARR1 targeting and induction of downstream genes to promote ovule initiation. Enhanced CK signaling partially rescued the reduced SNS phenotype of BR-deficient/insensitive mutants whereas enhanced BR signaling failed to rescue the low SNS of CK-deficient mutants, suggesting that BR regulates ovule initiation and SNS through CK-mediated and CK-independent pathways. Our study thus reveals that interaction between BR and CK promotes ovule initiation and increases seed number, providing important clues for increasing the seed yield of dicot crops. This article is protected by copyright. All rights reserved.
Intelligent self‐control of carbon metabolic flux in SecY‐engineered Escherichia coli for xylitol biosynthesis from xylose‐glucose mixtures

Xylitol is a salutary sugar substitute that has been widely used in the food, pharmaceutical, and chemical industries. Co‐fermentation of xylose and glucose by metabolically engineered cell factories is a promising alternative to chemical hydrogenation of xylose for commercial production of xylitol. Here, we engineered a mutant of SecY protein‐translocation channel (SecY [ΔP]) in xylitol‐producing Escherichia coli JM109 (DE3) as a passageway for xylose uptake. It was found that SecY (ΔP) channel could rapidly transport xylose without being interfered by XylB‐catalyzed synthesis of xylitol‐phosphate, which is impossible for native XylFGH and XylE transporters. More importantly, with the coaction of SecY (ΔP) channel and carbon catabolite repression (CCR), the flux of xylose to the pentose phosphate (PP) pathway and the xylitol synthesis pathway in E. coli could be automatically controlled in response to glucose, thereby ensuring that the mutant cells were able to fully utilize sugars with high xylitol yields. The E. coli cell factory developed in this study has been proven to be applicable to a broad range of xylose‐glucose mixtures, which is conducive to simplifying the mixed‐sugar fermentation process for efficient and economical production of xylitol.
An analysis of three different prostate cancer risk calculators applied prior to prostate biopsy: A Turkish cohort validation study

The study aimed to investigate the best‐performing of three risk calculators (RCs) for the Turkish population in predicting cancer‐free status and high‐risk prostate cancer (PCa) in patients undergoing transrectal ultrasound‐guided prostate biopsy. The electronic medical records of 527 patients who underwent prostate biopsy for the first time due to PSA of 0.3–50 ng/dl and/or cancer suspicion at digital rectal examination (DRE) between January 2017 and December 2020 were retrieved retrospectively. The predictive power of the RCs in the biopsy and the surgical cohort was calculated by two urologists using European Randomised Study of Screening for Prostate Cancer (ERSPC) RC, the North American Prostate Cancer Prevention Trial‐RC (PCPT‐RC), and the Prostate Biopsy Collaborative Group (PBCG)‐RC. All three RCs were successful in predicting PCa and high‐risk disease at ROC analysis (p < 0.0001). Of these three nomograms, PBCG‐RC outperformed PCPT‐RC 2.0 and ERSPC‐RH in predicting benign pathology outcomes at biopsy. A better performance of PBCG‐RC was also observed in terms of prediction of high‐risk disease at biopsy. Using any of the available RCs prior to biopsy is of greater assistance to prostate‐specific antigen and DRE than examination alone. The study results show that PBCG‐RC performed before biopsy has a higher predictive power than the other two RCs.
Power Quality Problems Mitigation using Dynamic Voltage Restorer in Egypt Thermal Research Reactor (ETRR-2)

Egypt thermal research reactor (ETRR-2) was subjected to several Power Quality Problems such as voltage sags/swells, harmonics distortion, and short interruption. ETRR-2 encompasses a wide range of loads which are very sensitive to voltage variations and this leads to several unplanned shutdowns of the reactor due to trigger of the Reactor Protection System (RPS). The Dynamic Voltage Restorer (DVR) has recently been introduced to protect sensitive loads from voltage sags and other voltage disturbances. It is considered as one of the most efficient and effective solution. Its appeal includes smaller size and fast dynamic response to the disturbance. This paper describes a proposal of a DVR to improve power quality in ETRR-2 electrical distribution systems . The control of the compensation voltage is based on d-q-o algorithm. Simulation is carried out by Matlab/Simulink to verify the performance of the proposed method.
fluorodeoxy- glucose positron emission tomography pattern and prognostic predictors in patients with anti- GABAB receptor encephalitis

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2021 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd. 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China 2China National Clinical Research Center for Neurological Diseases, Beijing, China 3Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China 4Collaborative Innovation Center for Brain Disorders, Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China
Electromagnetic interference from left ventricular assist devices detected in patients with implantable cardioverter‐defibrillators

Electromagnetic interference (EMI) from left ventricular assist devices (LVADs) can cause implantable cardioverter‐defibrillator (ICD) oversensing. We sought to assess the frequency of inappropriate shocks/oversensing due to LVAD‐related EMI and prospectively compare integrated (IB) versus dedicated bipolar (DB) sensing in patients with LVADs.
Joint GWAS and WGCNA uncover the genetic control of calcium accumulation under salt treatment in maize seedlings.

Soil salinization is an important factor threatening the yield and quality of maize. Ca2+ plays a considerable role in regulating plant growth under salt stress. Herein, we examined the shoot Ca2+ concentrations, root Ca2+ concentrations, and transport coefficients of seedlings in an association panel composed of 305 maize inbred lines under normal and salt conditions. A genome-wide association study was conducted by using the investigated phenotypes and 46,408 single-nucleotide polymorphisms of the panel. As a result, 53 significant SNPs were specifically detected under salt treatment, and 544 genes were identified in the linkage disequilibrium regions of these SNPs. According to the expression data of the 544 genes, we carried out a weighted coexpression network analysis. Combining the enrichment analyses and functional annotations, four hub genes (GRMZM2G051032, GRMZM2G004314, GRMZM2G421669, and GRMZM2G123314) were finally determined, which were then used to evaluate the genetic variation effects by gene-based association analysis. Only GRMZM2G123314, which encodes a pentatricopeptide repeat protein, was significantly associated with Ca2+ transport and the haplotype G-CT was identified as the superior haplotype. Our study brings novel insights into the genetic and molecular mechanisms of salt stress response and contributes to the development of salt-tolerant varieties in maize. This article is protected by copyright. All rights reserved.
Commentary: Scheimpflug imaging for evaluation of posterior lens capsule in pediatric traumatic cataract

of the images markedly. However, we could reliably image the posterior capsule in all our cases. The main reason could be the absence of the nuclear sclerosis component in children. Also, patients with significant media opacities (except lenticular) were excluded from the study. We analyzed the patients after a mean duration of 41.7 ± 7.8 days, which may be an important factor as well. The PCT margin becomes thick and fibrous approximately after 6 weeks. [15] The fibrous margins are easier to be picked in such imaging techniques. Any imaging method performed soon after trauma may miss such subtle changes.
Evolution of a Cavitating Bubble in a Nonuniform Pressure Field

The cavitation erosion problem is not a new one; however, it is still important and even becomes more pressing. This is associated with requirements to justify and extend service life of power-generating plants while obviously seeking the maximum efficiency. Currently semiempirical correlation relations are typically used in pump designing for prediction of modes of operation that may be hazardous in terms of development of cavitation erosion [1, 2]. It appears, however, that a progress can be made in this field by introducing numerical modeling of flow with direct modeling of the cavitation erosion process. This optimism is based on an established fact that the major effect of erosion damage is observed in the mode of operation between the “NPSH-incipient” mode (mode of activation of vapor-phase formation centers) and the “NPSH-3%” mode (mode where a noticeable vapor volume content is produced in the near-wall layer), i.e. in the mode of operation where the vapor volume content is small and its effect on flow characteristics can be neglected. © 2007 ASME
PHARMACEUTICAL PACKAGING: CURRENT TRENDS AND FUTURE Original Article

Pharmaceutical packaging is one market across the globe which is advancing at constant pace. It is expected that market will grow to worth $78.79 Billion by 2018 [1]. Packaging is a key for sale, safety and success. Like other packaged goods, pharmaceuticals packaging need to be in such a manner that it will provide speedy packaging, protection, identification, product quality, patient comfort, display and needs of security. Advancement in research of pharmaceuticals development had always being dependent on the packaging technology. Maintaining integrity of pharmaceuticals during storage, shipment, and delivery is assured by quality of packaging available. This article reviewing current pharmaceutical packaging trends and predicting the packaging outcomes in future.
Full-wave analysis of radiating planar resonators with the method of lines

The method of lines (MoL) is extended to analyze radiating planar resonators by the use of absorbing boundary conditions. For stratified layers, an equivalent network is derived to set up a system equation by simple multiplication of hybrid matrices. As an example, the complex resonant frequency of a microstrip patch is computed and compared to results achieved with the integral equation method in spectral domain. The radiation in the near-field region is depicted by a vector plot of the energy flow, given by the real part of the Poynting vector. >
Mechanisms underlying activation of retinal bipolar cells through targeted electrical stimulation: a computational study

Objective. Retinal implants have been developed to electrically stimulate healthy retinal neurons in the progressively degenerated retina. Several stimulation approaches have been proposed to improve the visual percept induced in patients with retinal prostheses. We introduce a computational model capable of simulating the effects of electrical stimulation on retinal neurons. Leveraging this computational platform, we delve into the underlying mechanisms influencing the sensitivity of retinal neurons’ response to various stimulus waveforms. Approach. We implemented a model of spiking bipolar cells (BCs) in the magnocellular pathway of the primate retina, diffuse BC subtypes (DB4), and utilized our multiscale admittance method (AM)-NEURON computational platform to characterize the response of BCs to epiretinal electrical stimulation with monophasic, symmetric, and asymmetric biphasic pulses. Main results. Our investigations yielded four notable results: (a) the latency of BCs increases as stimulation pulse duration lengthens; conversely, this latency decreases as the current amplitude increases. (b) Stimulation with a long anodic-first symmetric biphasic pulse (duration > 8 ms) results in a significant decrease in spiking threshold compared to stimulation with similar cathodic-first pulses (from 98.2 to 57.5 µA). (c) The hyperpolarization-activated cyclic nucleotide-gated channel was a prominent contributor to the reduced threshold of BCs in response to long anodic-first stimulus pulses. (d) Finally, extending the study to asymmetric waveforms, our results predict a lower BCs threshold using asymmetric long anodic-first pulses compared to that of asymmetric short cathodic-first stimulation. Significance. This study predicts the effects of several stimulation parameters on spiking BCs response to electrical stimulation. Of importance, our findings shed light on mechanisms underlying the experimental observations from the literature, thus highlighting the capability of the methodology to predict and guide the development of electrical stimulation protocols to generate a desired biological response, thereby constituting an ideal testbed for the development of electroceutical devices.
Time-division self-referencing multichannel spectral SPR sensor without mechanical scanning

A multichannel spectral surface plasmon resonance (SPR) sensor module which provides self-referencing capability has been designed to inhibit error influences arising from light source instability. The device timely refreshes the light intensity baseline based on periodical scans over several channels. In particular, the scan operation is achieved by changing optical media on the optical path instead of conventional mechanical scanning. Experiments demonstrate that the sensor module achieves a refractive index resolution level up to ∼ 9.3 × 10− 7 RIU.
Bio-cultural Aspects of the Meitei Women Football Players of Manipur

Abstract This paper attempts to study the bio-cultural aspects of the Meitei women football players of Manipur based on 27 anthropometric variables and some socio-economic parameters from a total of 138 women of whom 38 individuals are regular playing football players of state to international level, while the rest 100 were the non-athlete controlled group. A trend of higher number of players from the bigger family size groups and moreover, maximum of them being belonged to the lowest income group have been observed. The football players have significantly broader bi-trochanteric, bi-iliocristale breadths and much larger girths of neck, upper arm, fore arm, thigh and calf, and also lean body mass than the controlled group. Discussions have been made on the football players in the light of their physical structure, exercise, and the socio-cultural background of the Meitei society.
Research of Postal Data mining system based on big data

With the rapid developing of cloud computing and big data technology, enterprises have accumulated vast amounts of data and all of them have got more effective treatment, so companies get greater value of market. This issue analyzed the data China Post has and proposed an architecture of China Post's data-digging system in large data environments and carried out a detailed design of precise process for China Post based on big data. Finally, we used China Post's data-digging system on the precise database marketing and personalized product recommendations and other aspects, and achieved good results.
Evolution of corneal epithelial remodeling after myopic laser in situ keratomileusis surgery measured by anterior segment optical coherence tomography combined with Placido disk

Purpose: To investigate patterns of short- and long-term variations in corneal epithelial thickness (CET) after myopic laser in situ keratomileusis (LASIK) using anterior segment optical coherence tomography (AS-OCT) combined with Placido disk-based topography. Methods: In this retrospective study, 36 subjects (72 eyes) who underwent LASIK myopic surgery and 53 healthy subjects (106 eyes) who served as controls were enrolled. AS-OCT (MS-39) was performed in all patients before, 1 day, 1 month, and 6 months after surgery. Statistical analysis was performed to analyze CET changes over time after LASIK and to detect patterns of definitive CET remodeling compared to healthy subjects. Multivariate analysis was performed to look for possible predictors of final CET. Results: There was no statistically significant difference between groups in terms of demographic and anterior segment parameters (all P > 0.05). After LASIK, all sectors and rings got thicker over time (1.62–8.32 μm; P < 0.01). Except for the central sector, all areas achieved the thickest CET value one day after surgery with a progressive epithelial thinning between 1 and 6 months of follow-up. Changes on CET occurred independently of the grade of myopia before LASIK or final refraction (P > 0.05). None of the clinical variables studied, including diopters corrected, were found to be correlated with final CET (P > 0.05). Conclusion: Independent of anterior segment parameters and diopters corrected, CET becomes thicker after LASIK surgery. Central and inner ring sectors thicken more than those more peripheral. CET remodeling after myopic LASIK should be taken into consideration when planning refractive surgery.
Optimal design for one-dimensional photonic crystal waveguide

This paper proposes a logical method to design and optimize one-dimensional photonic crystal waveguides (PCWs). The logic is deduced from practical issues such as the fabrication of the waveguide structures and the subsequent optical coupling to other conventional waveguides. It is found that the individual layer thickness of an optimally designed PCW is exactly one quarter of the projection of the effective wavelength in the direction perpendicular to the layer plane. The paper also describes a handy way of finding the thickness of the central guiding layer of a symmetric waveguide. In order to demonstrate that the proposed logic and schemes are indeed functional, detailed numerical calculations are provided for a model PCW structure composed of a GaAs-AlAs-oxide system and an air-guiding layer.
Is early activity resumption after paediatric concussion safe and does it reduce symptom burden at 2 weeks post injury? The Pediatric Concussion Assessment of Rest and Exertion (PedCARE) multicentre randomised clinical trial

Objective Investigate whether resuming physical activity (PA) at 72 hours post concussion is safe and reduces symptoms at 2 weeks, compared with resting until asymptomatic. Methods Real-life conditions, multicentre, single-blinded randomised clinical trial, conducted in three Canadian paediatric emergency departments (ED). Children/youth aged 10–<18 years with acute concussion were recruited between March 2017 and December 2019, and randomly assigned to a 4-week stepwise return-to-PA protocol at 72 hours post concussion even if symptomatic (experimental group (EG)) or to a return-to-PA once asymptomatic protocol (control group (CG)). The primary outcome was self-reported symptoms at 2 weeks using the Health and Behaviour Inventory. Adherence was measured using accelerometers worn 24 hours/day for 14 days post injury. Adverse events (AE) (worsening of symptoms requiring unscheduled ED or primary care visit) were monitored. Multivariable intention-to-treat (ITT) and per-protocol analyses adjusting for prognostically important covariates were examined. Missing data were imputed for the ITT analysis. Results 456 randomised participants (EG: N=227; mean (SD) age=13.3 (2.1) years; 44.5% women; CG: N=229; mean (SD) age=13.3 (2.2) years; 43.7% women) were analysed. No AE were identified. ITT analysis showed no strong evidence of a group difference at 2 weeks (adjusted mean difference=−1.3 (95% CI:−3.6 to 1.1)). In adherent participants, initiating PA 72 hours post injury significantly reduced symptoms 2 weeks post injury, compared with rest (adjusted mean difference=−4.3 (95% CI:−8.4 to –0.2)). Conclusion Symptoms at 2 weeks did not differ significantly between children/youth randomised to initiate PA 72 hours post injury versus resting until asymptomatic; however, many were non-adherent to the intervention. Among adherent participants, early PA was associated with reduced symptoms at 2 weeks. Resumption of PA is safe and may be associated with milder symptoms at 2 weeks. Level of evidence 1b. Trial registration number NCT02893969. Registry name Pediatric Concussion Assessment of Rest and Exertion (PedCARE).