Miracle-dz/UniFAR-FTUs huggingface dataset:
Obesity-induced protein carbonylation in murine adipose tissue regulates the DNA-binding domain of nuclear zinc finger proteins

In obesity-linked insulin resistance, oxidative stress in adipocytes leads to lipid peroxidation and subsequent carbonylation of proteins by diffusible lipid electrophiles. Reduction in oxidative stress attenuates protein carbonylation and insulin resistance, suggesting that lipid modification of proteins may play a role in metabolic disease, but the mechanisms remain incompletely understood. Herein, we show that in vivo, diet-induced obesity in mice surprisingly results in preferential carbonylation of nuclear proteins by 4-hydroxy-trans-2,3-nonenal (4-HNE) or 4-hydroxy-trans-2,3-hexenal (4-HHE). Proteomic and structural analyses revealed that residues in or around the sites of zinc coordination of zinc finger proteins, such as those containing the C2H2 or MATRIN, RING, C3H1, or N4-type DNA-binding domains, are particularly susceptible to carbonylation by lipid aldehydes. These observations strongly suggest that carbonylation functionally disrupts protein secondary structure supported by metal coordination. Analysis of one such target, the nuclear protein estrogen-related receptor γ (ERR-γ), showed that ERR-γ is modified by 4-HHE in the obese state. In vitro carbonylation decreased the DNA-binding capacity of ERR-γ and correlated with the obesity-linked down-regulation of many key genes promoting mitochondrial bioenergetics. Taken together, these findings reveal a novel mechanistic connection between oxidative stress and metabolic dysfunction arising from carbonylation of nuclear zinc finger proteins, such as the transcriptional regulator ERR-γ.
Maximum Output Networks for Telephone Substation and Repeater Circuits

Ideal telephone substation and repeater circuits are shown to present output and input requirements which can be met by a type of circuit containing four resistances, each of which has maximum output; maximum output is found to involve biconjugacy, i.e., the four resista. nces fall into two pairs without active electrical connection between the two resistances of either pair; all circuits meeting these requirements with the minimum number of elements are enumerated; the necessary formulas for proportioning these circuits and also circuits having superflous elements are derived. The discussion of the properties of these four-resistance circuits, to which a consideration of three-resistance eire-uits is added, is a contribution to the important problem of the properties of the most general circuit containing ideal transformers.
Coplanar waveguides on silicon substrate with thick oxidized porous silicon (OPS) layer

The problem of high dielectric loss of waveguide on silicon in the microwave region can be solved by utilizing a thick silicon dioxide layer that is formed by silicon substrate anodization and oxidation processes. Coplanar waveguides (CPW's) are fabricated on silicon substrate with a 20-μm-thick oxidized porous silicon (OPS) layer and demonstrate very high performance of 0.1-dB/mm attenuation at 4 GHz. Thus, the OPS process is promising for gigaherz applications of silicon substrates.
Pathophysiological abnormalities in the brains of Spontaneously Diabetic Torii-Lepr fa (SDT fatty) rats, a novel type 2 diabetic model

In recent years, a relationship between diabetes and neurodegenerative diseases, such as Parkinson’s disease, Alzheimer disease or depression, has been proposed. In this study, pathophysiological changes in the brain, especially in the hippocampus, of male SDT fatty rats with obesity and hyperglycemia were investigated. Brains of SD rats and SDT fatty rats were collected at 32 and 58 weeks of age, and parietal cortical thickness and number of pyramidal cells in the hippocampal cornu ammonis 1 and 3 (CA1 and CA3) regions were measured. At 58 weeks of age, the parietal cortical thickness and number of pyramidal cells in the hippocampal CA1 and CA3 regions were lower in SDT fatty rats than in age-matched SD rats. Measurements of mRNA in rat brains at 58 weeks of age showed that the expression of genes related to inflammatory responses (S100a9, TNFα, NF-κB) was elevated in SDT fatty rats. From the aforementioned results, changes suggestive of brain atrophy and impairment in cognitive function were observed in male SDT fatty rat brains.
Community engagement in global health education supports equity and advances local priorities: an eight year Ecuador-Canada partnership

Background Global health education initiatives inconsistently balance trainee growth and benefits to host communities. This report describes a global health elective for medical trainees that focuses on community engagement and participatory research to provide mutually beneficial outcomes for the communities and trainees. Methods An eight-year university–community partnership, the Chilcapamba to Montreal Global Health Elective is a two-month shared decision-making research and clinical observership experience in rural Ecuador for medical trainees at McGill University, Canada. Research topics are set by matching community-identified priorities with skillsets and interests of trainees, taking into consideration local potential impact. Results Community outcomes included development of a Community Health Worker program, new collaborations with local organizations, community identification of health priorities, and generation of health improvement recommendations. Collaborative academic outputs included multiple bursary awards, conference presentations and published manuscripts. Conclusion This medical global health elective engages communities using participatory research to prioritise socially responsible and locally beneficial outcomes.
Pulse-Width Modulation DC Motor Control

In order to control the speed of a dc series field motor at different required torque levels, it is necessary to adjust the voltage applied to the motor. For any particular constant voltage the motor speed is determined solely by the torque requirements and top speed is reached under minimum torque conditions. When a series motor is used as a traction drive for vehicles, it is desirable to control the voltage to the motor to fit the various torque requirements of grades, speed, and load. The common method of varying the speed of the motor is by inserting resistance in series with motor to reduce the supplied power. This type of motor speed control is very inefficient and wasteful of battery power due to the I<R>2</R>R loss, especially under high current, high torque conditions.
Influence of Real-Information to Change Tourists' Travel Route

The tourism system as a whole is becoming less sustainable, both because of its overall rapid growth and the unwillingness to change travel behavior (tourists). In the field of the tourism, the tourists' activities have influences on the protection and development of the natural scenic. In order to understand the tourist' intention to change travel route based on real-time information, this paper adds trust to the model of theory of planned behavior (TPB). Exploratory and confirmatory factor analysis are used to identify and confirm the constructs. In addition, structural equation modeling was established to test the measure model. Results indicate that the attitude, subjective norm and perceived behavioral control have positive effect on the behavioral intention of changing travel route according to real-time information. Moreover, trust also has positive influence on behavioral intention via three antecedents of intention. The findings have implications for predicting the tourist's intention of travel route change.
A Current Distribution for Broadside Arrays Which Optimizes the Relationship between Beam Width and Side-Lobe Level

A one-parameter family of current distributions is derived for symmetric broadside arrays of equally spaced point sources energized in phase. For each value of the parameter, the corresponding current distribution gives rise to a pattern in which (1) all the side lobes are at the same level; and (2) the beam width to the first null is a minimum for all patterns arising from symmetric distributions of in-phase currents none of whose side lobes exceeds that level. Design curves relating the value of the parameter to side-lobe level as well as the relative current values expressed as a function of side-lobe level are given for the cases of 8-, 12-, 16-, 20-, and 24-element linear arrays.
Performance of Oman transmission system with distributed generation

The paper presents simulation studies of installing distributed generation (DG) at a number of grid stations in the main transmission system of Oman. The diesel-engine driven generator units are required on a temporary basis to aid in meeting the peak demand. A digital model is developed to simulate the system including power plants, transmission system, loads and the proposed DG. The simulation studies are performed by using the DIgSILENT software package. The objective of the studies is to demonstrate effects of the DG in improving system performance in terms of voltage profile, line and transformer loadings, and transmission losses. The results include comparison of the contribution of individual generation at each site and the case with all proposed distributed generators installed.
A Study of Locking Phenomena in Oscillators

Impression of an external signal upon an oscillator of similar fundamental frequency affects both the instantaneous amplitude and instantaneous frequency. Using the assumption that time constants in the oscillator circuit are small compared to the length of one beat cycle, a differential equation is derived which gives the oscillator phase as a function of time. With the aid of this equation, the transient process of "pull-in" as well as the production of a distorted beat note are described in detail. It is shown that the same equation serves to describe the motion of a pendulum suspended in a viscous fluid inside a rotating container. The whole range of locking phenomena is illustrated with the aid of this simple mechanical model.
BMS-345541 inhibits airway inflammation and epithelial-mesenchymal transition in airway remodeling of asthmatic mice

The present study aimed to investigate the possible effects and regulatory mechanism of the inhibitor of nuclear factor-κB kinase complex β subunit (IKKβ) inhibitor BMS-345541 on airway inflammation, airway remodeling and epithelial-mesenchymal transition (EMT) in an ovalbumin (OVA) exposure asthma model in mice. The asthma mouse model was generated by sensitization and challenge with OVA. BMS-345541/dimethyl sulfoxide (DMSO) was administered perorally dairy in two therapeutic groups throughout the entire OVA challenge process. At 24 h following the last challenge, airway hyperresponsiveness (AHR) and airway inflammation were examined, and serum, bronchoalveolar lavage fluid (BALF) and lung samples were collected. Lung tissue was stained and assessed for pathological changes. The total number and classification of inflammatory cells in the BALF were examined. Levels of transforming growth factor β1 (TGFβ1) in the serum and BALF were measured using an enzyme-linked immunosorbent assay. The differential expression of EMT regulators E-cadherin and vimentin was detected by immunohistochemical staining, reverse transcription-quantitative polymerase chain reaction analysis and western blot analysis. The results showed that OVA successfully induced allergic asthma. The asthmatic mice had AHR, airway inflammation, airway remodeling, a high expression of TGFβ1, and evidence of EMT. Following BMS-345541 treatment, there was significant inhibition of pathophysiological signs, including increased pulmonary eosinophilia infiltration, mucus hypersecretion and AHR. Treatment with BMS-345541 significantly reduced levels of TGFβ1. In addition, BMS-345541 notably downregulated the expression of vimentin and increased the expression of E-cadherin. These data suggested that the increased secretion of TGFβ1 induced by asthmatic inflammation can lead to EMT, and the IKKβ inhibitor BMS-345541 may alter airway remodeling by preventing EMT in an OVA asthma model. Therefore, IKKβ inhibitors require investigation as potential asthma therapies.
In vitro–transcribed guide RNAs trigger an innate immune response via the RIG-I pathway

Clustered, regularly interspaced, short palindromic repeat (CRISPR)–CRISPR-associated 9 (Cas9) genome editing is revolutionizing fundamental research and has great potential for the treatment of many diseases. While editing of immortalized cell lines has become relatively easy, editing of therapeutically relevant primary cells and tissues can remain challenging. One recent advancement is the delivery of a Cas9 protein and an in vitro–transcribed (IVT) guide RNA (gRNA) as a precomplexed ribonucleoprotein (RNP). This approach allows editing of primary cells such as T cells and hematopoietic stem cells, but the consequences beyond genome editing of introducing foreign Cas9 RNPs into mammalian cells are not fully understood. Here, we show that the IVT gRNAs commonly used by many laboratories for RNP editing trigger a potent innate immune response that is similar to canonical immune-stimulating ligands. IVT gRNAs are recognized in the cytosol through the retinoic acid–inducible gene I (RIG-I) pathway but not the melanoma differentiation–associated gene 5 (MDA5) pathway, thereby triggering a type I interferon response. Removal of the 5’-triphosphate from gRNAs ameliorates inflammatory signaling and prevents the loss of viability associated with genome editing in hematopoietic stem cells. The potential for Cas9 RNP editing to induce a potent antiviral response indicates that care must be taken when designing therapeutic strategies to edit primary cells.
Relays and Breakers for High-Speed Single-Pole Tripping and Reclosing

THE advantages of fast reclosing of transmission-line circuit breakers have been realized for a number of years. This experience has been gained on the basis of three-pole reclosures. One step beyond three-pole tripping and reclosure is single-pole operation. It is arranged so that on single phase-to-ground faults only the faulty phase wire is disconnected at each end of the line and then immediately reclosed. This allows synchronizing current to flow over the two sound-phase conductors during the time the faulted phase wire is out of service. With single-pole tripping slower speed reclosing, as compared to three-pole operation, can be utilized with a definite gain in the stability limit.1
Identifying therapeutic targets from spontaneous beneficial brain lesions

Brain damage can occasionally result in paradoxical functional benefit, which could help identify therapeutic targets for neuromodulation. However, these beneficial lesions are rare and lesions in multiple different brain locations can improve the same symptom. Using a technique called lesion network mapping, we show that heterogeneous lesion locations resulting in tremor relief are all connected to common nodes in the cerebellum and thalamus, the latter of which is a proven deep brain stimulation target for tremor. These results suggest that lesion network mapping can identify the common substrate underlying therapeutic lesions and effective therapeutic targets. Ann Neurol 2018;83:153–157
An Occlusion-Robust Feature Selection Framework in Pedestrian Detection †

Better features have been driving the progress of pedestrian detection over the past years. However, as features become richer and higher dimensional, noise and redundancy in the feature sets become bigger problems. These problems slow down learning and can even reduce the performance of the learned model. Current solutions typically exploit dimension reduction techniques. In this paper, we propose a simple but effective feature selection framework for pedestrian detection. Moreover, we introduce occluded pedestrian samples into the training process and combine it with a new feature selection criterion, which enables improved performances for occlusion handling problems. Experimental results on the Caltech Pedestrian dataset demonstrate the efficiency of our method over the state-of-art methods, especially for the occluded pedestrians.
Synthetic voices for computers

The two methods described for giving voices to computers recognize the importance of economical storage of speech information and extensive vocabularies, and consequently are based on principles of speech synthesis. The first, formant synthesis, generates connected speech from low-bit-rate representations of spoken words. The second, text synthesis, produces connected speech solely from printed English text. For both methods the machine must contain stored knowledge of fundamental rules of language and acoustic constraints of human speech. Formant synthesis from an input information rate of about 1000 bits per second is demonstrated, as is text synthesis from a rate of about 75 bits per second. To give the reader an opportunity to evaluate some of the results described, a sample recording is available; see Appendix A for details.
A Practical Approach for High Precision Reconstruction of a Motorcycle Trajectory Using a Low-Cost Multi-Sensor System

Motorcycle drivers are considered among the most vulnerable road users, as attested by the number of crashes increasing every year. The significant part of the fatalities relates to “single vehicle” loss of control in bends. During this investigation, a system based on an instrumented multi-sensor platform and an algorithmic study was developed to accurately reconstruct motorcycle trajectories achieved when negotiating bends. This system is used by the French Gendarmerie in order to objectively evaluate and to examine the way riders take their bends in order to better train riders to adopt a safe trajectory and to improve road safety. Data required for the reconstruction are acquired using a motorcycle that has been fully instrumented (in VIROLO++ Project) with several redundant sensors (reference sensors and low-cost sensors) which measure the rider actions (roll, steering) and the motorcycle behavior (position, velocity, acceleration, odometry, heading, and attitude). The proposed solution allowed the reconstruction of motorcycle trajectories in bends with a high accuracy (equal to that of fixed point positioning). The developed algorithm will be used by the French Gendarmerie in order to objectively evaluate and examine the way riders negotiate bends. It will also be used for initial training and retraining in order to better train riders to learn and estimate a safe trajectory and to increase the safety, efficiency and comfort of motorcycle riders.
A Non-Enzymatic Method to Obtain a Fat Tissue Derivative Highly Enriched in Adipose Stem Cells (ASCs) from Human Lipoaspirates: Preliminary Results

Adipose tissue possesses phenotypic gene expression characteristics that are similar to human mesenchymal stem cells (hMSCs). Nevertheless, the multilineage potential may be inhibited, and cells may not expand adequately to satisfy the requirements of Good Manufacturing Practice (cGMP). An autologous hMSC-enriched fat product would fulfil the void from a biomedical and clinical perspective. In this study, we suggest a novel mechanism using a closed system without enzymes, additives or other modifications, which will produce non-expanded, accessible material. This decentralized fat product, unlike unprocessed lipoaspirates, adequately encloses the vascular stroma with adipocytes and stromal stalks along with their vascular channels and lumina. This fat product contained hASCs and fewer hematopoietic elements such as lipoaspirates, which were digested enzymatically according to flow cytometric investigations, and molecular analysis also showed significant hASC uniformity within the cells of the stromal vascular tissue. Moreover, the fat product produced a higher quantity of hASCs similar to hMSCs in isolation with the typical characteristics of an osteogenic, chondrogenic and adipogenic lineage. Interestingly, these properties were evident in the non-enzymatic derived adipose tissue, as opposed to hASCs in isolation from the enzymatically digested lipoaspirates, suggesting that the aforementioned procedure may be an adequate alternative to regenerate and engineer tissue for the treatment of various medical conditions and promote efficient patient recovery.
Implantable cardioverter‐defibrillator therapy in device recipients who survived a cardiac arrest associated with a reversible cause

Guideline recommendations for implantable cardioverter‐defibrillators (ICD) for secondary prevention of sudden cardiac arrest (SCA) have excluded patients with reversible causes. We previously demonstrated mortality benefit with the ICD in survivors of SCA associated with reversible causes other than myocardial infarction (MI) or ischemia treated with coronary revascularization. In the current study, we examined the incidence of ICD therapy in patients with SCA related to reversible causes.
A New High Efficiency Power Amplifier for Modulated Waves

This paper introduces a new form of linear power amplifier for modulated radio-frequency waves. Plate circuit efficiencies of sixty to sixty-five per cent independent of modulation are obtained by means of the combined action of varying load distribution among the tubes and varying circuit impedance over the modulation cycle. The theory of operation is developed and detailed observations on the behavior of tubes in the new circuit are given in the paper. The use of stabilized feedback in connection with this circuit is discussed and significant measurements on a laboratory model of a fifty-kilowatt transmitter are shown.
Induction motor resistance ring width

The effect which the width of resistance rings has on the secondary resistance of squirrel cage induction motors has been subjected to a mathematical analysis. It is found that the width, in a radial direction, of these rings which connect the conductors of a squirrel cage rotor, need never exceed the pole pitch, and probably half of that value is sufficient. Methods for determining the current distribution in the resistance ring, and for determining the the effective width and resistance are demonstrated.
Psychometric Evaluation of Clinical Learning Motivation Scale

C l i n M e d International Library Citation: Erci B (2015) Psychometric Evaluation of Clinical Learning Motivation Scale. Int Arch Nurs Health Care 1:018 Received: August 26, 2015: Accepted: November 22, 2015: Published: November 26, 2015 Copyright: © 2015 Erci B. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Erci. Int Arch Nurs Health Care 2015, 1:1 ISSN: 2469-5823