Miracle-dz/UniFAR-FTUs huggingface dataset:
Using Telehealth for Pediatric, Adolescent, and Adult Sexual Assault Forensic Medical Examinations: An Integrative Review

ABSTRACT Objective Improved access to qualified nurse examiners to perform sexual assault forensic examinations is needed. This integrative review examines the current research literature on synchronous “real-time or live” telehealth support and guidance during pediatric, adolescent, and adult sexual abuse/assault forensic examinations. Methods Informational databases (CINAHL, Health Source: Nursing/Academic Edition, Medline, PsychInfo, and Violence & Abuse Abstracts) were searched, and research articles including live telehealth for sexual assault survivors were reviewed (n = 98). Results Review of the articles resulted in the inclusion of seven studies that utilized live video telehealth during the sexual assault forensic examination. Conclusion The current research literature supports the premise that synchronous telehealth is a promising modality for this patient population. However, the lack of large comprehensive studies warrants additional research to understand outcomes and develop best practices. Additional research studies are needed to evaluate the effectiveness, cost, and criminal justice impact of this intervention.
Comparative functional survival and equivalent annual cost of 3 long-lasting insecticidal net (LLIN) products in Tanzania: A randomised trial with 3-year follow up

Background Two billion long-lasting insecticidal nets (LLINs) have been procured for malaria control. A functional LLIN is one that is present, is in good physical condition, and remains insecticidal, thereby providing protection against vector-borne diseases through preventing bites and killing disease vectors. The World Health Organization (WHO) prequalifies LLINs that remain adequately insecticidal 3 years after deployment. Therefore, institutional buyers often assume that prequalified LLINs are functionally identical with a 3-year lifespan. We measured the lifespans of 3 LLIN products, and calculated their cost per year of functional life, to demonstrate the economic and public health importance of procuring the most cost-effective LLIN product based on its lifespan. Methods and findings A randomised double-blinded trial of 3 pyrethroid LLIN products (10,571 nets in total) was conducted at 3 follow-up points: 10 months (August–October 2014), 22 months (August–October 2015), and 36 months (October–December 2016) among 3,393 households in Tanzania using WHO-recommended methods. Primary outcome was LLIN functional survival (LLIN present and in serviceable condition). Secondary outcomes were (1) bioefficacy and chemical content (residual insecticidal activity) and (2) protective efficacy for volunteers sleeping under the LLINs (bite reduction and mosquitoes killed). Median LLIN functional survival was significantly different between the 3 net products (p = 0.001): 2.0 years (95% CI 1.7–2.3) for Olyset, 2.5 years (95% CI 2.2–2.8) for PermaNet 2.0 (hazard ratio [HR] 0.73 [95% CI 0.64–0.85], p = 0.001), and 2.6 years (95% CI 2.3–2.8) for NetProtect (HR = 0.70 [95% CI 0.62–0.77], p < 0.001). Functional survival was affected by accumulation of holes, leading to users discarding nets. Protective efficacy also significantly differed between products as they aged. Equivalent annual cost varied between US$1.2 (95% CI $1.1–$1.4) and US$1.5 (95% CI $1.3–$1.7), assuming that each net was priced identically at US$3. The 2 longer-lived nets (PermaNet and NetProtect) were 20% cheaper than the shorter-lived product (Olyset). The trial was limited to only the most widely sold LLINs in Tanzania. Functional survival varies by country, so the single country setting is a limitation. Conclusions These results suggest that LLIN functional survival is less than 3 years and differs substantially between products, and these differences strongly influence LLIN value for money. LLIN tendering processes should consider local expectations of cost per year of functional life and not unit price. As new LLIN products come on the market, especially those with new insecticides, it will be imperative to monitor their comparative durability to ensure that the most cost-effective products are procured for malaria control.
EFFECT OF TRINEXAPAC-ETHYL ON GROWTH AND YIELD OF SUGARCANE

Growth regulators can be used to further retard or inhibit vegetative growth. In this sense, the objective of this study was to determine the effects of age and number of trinexapac-ethyl applications on the growth and yield of sugarcane. The experiment was in a randomized complete block design with four replications. The treatments were in a 3 x 2 + 2 factorial arrangement, where factor A corresponded to the application times of the plant growth regulator (120, 200 and 240 days after bud burst (DAB) of sugarcane) and factor B to the number of applications (one or two applications). In addition, two controls (one with three applications and another application without the regulator) were added. The application of trinexapac-ethyl decreased the number and the distance between buds, height, root volume and sugarcane yield. The sequential application (2 or 3 times) induced an increase in stem diameter and three applications of the product increased the number of plant tillers. The use of growth regulators applied at 240 DAB has reduced plant height, however without changing the number of buds. It can be concluded that trinexapac-ethyl changes sugarcane growth and yield, regardless of season and number of applications.
Increased FOXL2 expression alters uterine structures and functions†

Abstract The transcription factor forkhead box L2 (FOXL2) regulates sex differentiation and reproductive function. Elevated levels of this transcription factor have been observed in the diseases of the uterus, such as endometriosis. However, the impact of elevated FOXL2 expression on uterine physiology remains unknown. In order to determine the consequences of altered FOXL2 in the female reproductive axis, we generated mice with over-expression of FOXL2 (FOXL2OE) by crossing Foxl2LsL/+ with the Progesterone receptor Pgrcre model. FOXL2OE uterus showed severe morphological abnormality including abnormal epithelial stratification, blunted adenogenesis, increased endometrial fibrosis, and disrupted myometrial morphology. In contrast, increasing FOXL2 levels specifically in uterine epithelium by crossing the Foxl2LsL/+ with the lactoferrin Ltficre mice resulted in the eFOXL2OE mice with uterine epithelial stratification but without defects in endometrial fibrosis and adenogenesis, demonstrating a role of the endometrial stroma in the uterine abnormalities of the FOXL2OE mice. Transcriptomic analysis of 12 weeks old Pgrcre and FOXL2OE uterus at diestrus stage showed multiple signaling pathways related with cellular matrix, wnt/β-catenin, and altered cell cycle. Furthermore, we found FOXL2OE mice were sterile. The infertility was caused in part by a disruption of the hypophyseal ovarian axis resulting in an anovulatory phenotype. The FOXL2OE mice failed to show decidual responses during artificial decidualization in ovariectomized mice demonstrating the uterine contribution to the infertility phenotype. These data support that aberrantly increased FOXL2 expressions in the female reproductive tract can disrupt ovarian and uterine functions. Summary Sentence FOXL2 overexpression in the uterus induced epithelial stratification, blunted adenogenesis, increased fibrosis, and disrupted myometrium leading to impaired decidual responses. Graphical Abstract
FOXL1 Regulates Lung Fibroblast Function via Multiple Mechanisms.

Fibroblasts provide a structural framework for multiple organs, and are essential for wound repair and fibrotic processes. Here, we demonstrate functional roles of forkhead box L1 (FOXL1), a transcription factor that characterizes the pulmonary origin of lung fibroblasts. We detected high FOXL1 transcript levels associated with DNA hypomethylation and super-enhancer formation in lung fibroblasts, in contrast to fibroblasts derived from other organs. RNA in situ hybridization and immunohistochemistry in normal lung tissue indicated that FOXL1 mRNA and protein are expressed in submucosal interstitial cells together with airway epithelial cells. Transcriptome analysis revealed that FOXL1 could control a broad array of genes that potentiate fibroblast function, including TAZ/YAP signature genes and PDGF receptor-α. FOXL1 silencing in lung fibroblasts attenuated cell growth and collagen gel contraction capacity, underscoring the functional importance of FOXL1 in fibroproliferative reactions. Of clinical importance, increased FOXL1 mRNA expression was found in fibroblasts of idiopathic pulmonary fibrosis (IPF) lung tissue. Our observations suggest that FOXL1 regulates multiple functional aspects of lung fibroblasts as a key transcription factor, and is involved in IPF pathogenesis.
In-situ formation and evolution of atomic defects in monolayer WSe2 under electron irradiation

Transition metal dichalcogenide (TMD) monolayers such as MoS2, MoSe2, MoTe2, WS2 and WSe2 have attracted significant interest due to their remarkable electronic and optical properties, exhibiting a direct band gap, enabling usability in electronics and optics. Their properties can be altered further by the introduction of lattice defects. In this work, the dynamics of the formation of electron-beam-induced lattice defects in monolayer WSe2 are investigated by in-situ spherical and chromatic aberration-corrected low-voltage transmission electron microscopy. We show and analyze the electron-dose-limited life of a monolayer WSe2 from the formation of isolated Se vacancies over extended defects such as vacancy lines, mirror twin boundaries (MTBs) and inversion domains towards the loss of W atoms leading to the formation of holes and finally the destruction of the monolayer. We identify, moreover, a new type of MTB. Our study extends the basic understanding of defect dynamics in monolayer WSe2, sheds further light on the electron radiation response and suggests new ways for engineering the in-plane architecture of TMDs.
Diversity of culturable gut bacteria associated with the field populations of cotton leafhopper (Amrasca biguttula biguttula) in India

Field populations of cotton leafhopper [Amrasca biguttula biguttula (Ishida)] exposed to heavy applications of imidacloprid, acephate, acetamiprid and dimethoate were collected from the seven cotton (Gossypium spp ) growing areas of the country. Thirty culturable bacteria were isolated from the guts of 16 populations of leafhoppers and were characterized through morphological and molecular methods. A good diversity of microflora was recorded across the location and is unique with respect to the locations. None of them are repeated except the genera Bacillus and Enterobacter. There was more number of gut microflora associated with the leafhoppers collected from Dharwad where the insecticide usage pattern and the number of sprays were very high as compared to other locations. Various Bacillus spp. were reported in the Dharwad population. The association of Enterococcus asburiae, Enterobacter silesiacus from the guts of leafhoppers of Guntur which was exposed to nine rounds of sprays of acephate, imidacloprid and dimethoate as compared to Bangalore which was not exposed to insecticides at all. Enterococcus hormaechei was isolated from the insects of Bangalore. The predominant bacterial genera identified in A.biguttula biguttula were Serratia, Bacillus, Enterococcus, Enterobacter, Pantoea, Methylobacterium, Stenotrophomonas, Pseudomonas and Paenibacillus.
Early access to antiretroviral therapy versus standard of care among HIV‐positive participants in Eswatini in the public health sector: the MaxART stepped‐wedge randomized controlled trial

The WHO recommends antiretroviral treatment (ART) for all HIV‐positive patients regardless of CD4 count or disease stage, referred to as “Early Access to ART for All” (EAAA). The health systems effects of EAAA implementation are unknown. This trial was implemented in a government‐managed public health system with the aim to examine the “real world” impact of EAAA on care retention and viral suppression.
A Research Note on Relationships Between the Vertical Jump and Standing Broad Jump in Law Enforcement Recruits: Implications for Lower-Body Power Testing

Abstract Lockie, RG, Moreno, MR, and Dawes, JJ. A research note on relationships between the vertical jump and standing broad jump in law enforcement recruits: implications for lower-body power testing. J Strength Cond Res 36(8): 2326–2329, 2022—Jump testing is often used to infer lower-body power in law enforcement recruits. The vertical jump (VJ) is most common, but can be equipment-intensive. The standing broad jump (SBJ) also provides a measure of lower-body power, requires less equipment, and could be practical for training staff with limited resources. There has been no analysis of the relationships between the VJ and SBJ in law enforcement recruits to ensure they measure similar qualities. This research note investigated the relationships between the VJ and SBJ in recruits from one agency. The sample included 71 men and 23 women who completed the VJ and SBJ before academy. Independent samples t-tests compared the sexes in both jump tests. Pearson's correlations calculated relationships between the VJ and SBJ variables (VJ height, height relative to body mass, peak power and power-to-body mass ratio calculated from VJ height; SBJ distance and distance relative to body mass) in all recruits combined, men, and women. Male recruits outperformed females in all absolute VJ and SBJ variables (p < 0.001), except for relative-to-body mass VJ and SBJ. There were large significant relationships between most jump variables for all recruits combined, men, and women (r = 0.371–0.684). Relative VJ and SBJ did not significantly relate (r = 0.123–0.203). There were generally strong relationships between the VJ and SBJ in recruits, although the relative data indicated some differences in qualities assessed by each jump. Nonetheless, training staff could use the SBJ as a lower-body absolute power indicator, especially with limited resources.
Investigation of magnetically driven passage of magnetic nanoparticles through eye tissues for magnetic drug targeting

This paper elucidates the feasibility of magnetic drug targeting to the eye by using magnetic nanoparticles (MNPs) to which pharmaceutical drugs can be linked. Numerical simulations revealed that a magnetic field gradient of 20 T m−1 seems to be promising for dragging magnetic multicore nanoparticles of about 50 nm into the eye. Thus, a targeting magnet system made of superconducting magnets with a magnetic field gradient at the eye of about 20 T m−1 was simulated. For the proof-of-concept tissue experiments presented here the required magnetic field gradient of 20 T m−1 was realized by a permanent magnet array. MNPs with an optimized multicore structure were selected for this application by evaluating their stability against agglomeration of MNPs with different coatings in water for injections, physiological sodium chloride solution and biological media such as artificial tear fluid. From these investigations, starch turned out to be the most promising coating material because of its stability in saline fluids due to its steric stabilization mechanism. To evaluate the passage of MNPs through the sclera and cornea of the eye tissues of domestic pigs (Sus scrofa domesticus), a three-dimensionally printed setup consisting of two chambers (reservoir and target chamber) separated by the eye tissue was developed. With the permanent magnet array emulating the magnetic field gradient of the superconducting setup, experiments on magnetically driven transport of the MNPs from the reservoir chamber into the target chamber via the tissue were performed. The resulting concentration of MNPs in the target chamber was determined by means of quantitative magnetic particle spectroscopy. It was found that none of the tested particles passed the cornea, but starch-coated particles could pass the sclera at a rate of about 5 ng mm−2 within 24 h. These results open the door for future magnetic drug targeting to the eye.
Response of radish to phosphorus and potassium fertilization on Histosols

Five field experiments were conducted from 1986 through 1988 to evaluate the response of radish (Raphanus sativus L.) to rate and source of P (triple super- phosphate and phosphoric acid) and to rate of K (KC1) on Histosols. Marketable radish root yields increased with P fertilization when the soil tested <13 mg P/dm 3 using a test for water-soluble P. No significant differences were due to P source. Results of leaf tissue analysis suggested that the critical concentration of P in radish leaves was 0.45%. Radish did not respond to K fertilization in any of the five experiments, even though preliminary soil-test K levels ranged from 20 to 102 K/dm 3 . Histosols used for crop production in Florida rarely test below 20 mg K/dm 3 ; thus, radish rarely would require supplementary K fertilization for optimal yield.
Exercise-Induced Changes in Bioactive Lipids Might Serve as Potential Predictors of Post-Exercise Hypotension. A Pilot Study in Healthy Volunteers

Post-exercise hypotension (PEH) is the phenomenon of lowered blood pressure after a single bout of exercise. Only a fraction of people develops PEH but its occurrence correlates well with long-term effects of sports on blood pressure. Therefore, PEH has been suggested as a suitable predictor for the effectivity of exercise as therapy in hypertension. Local vascular bioactive lipids might play a potential role in this context. We performed a cross-over clinical pilot study with 18 healthy volunteers to investigate the occurrence of PEH after a single short-term endurance exercise. Furthermore, we investigated the plasma lipid profile with focus on arachidonic acid (AA)-derived metabolites as potential biomarkers of PEH. A single bout of ergometer cycling induced a significant PEH in healthy volunteers with the expected high inter-individual variability. Targeted lipid spectrum analysis revealed significant upregulation of several lipids in the direct post-exercise phase. Among these changes, only 15- hydroxyeicosatetranoic acid (HETE) correlated significantly with the extent of PEH but in an AA-independent manner, suggesting that 15-HETE might act as specific PEH-marker. Our data indicate that specific lipid modulation might facilitate the identification of patients who will benefit from exercise activity in hypertension therapy. However, larger trials including hypertonic patients are necessary to verify the clinical value of this hypothesis.
A Systematic Review of the Hematopoietic Acute Radiation Syndrome (H-ARS) in Canines and Non-human Primates: Acute Mixed Neutron/Gamma vs. Reference Quality Radiations

Abstract A systematic review of relevant studies that determined the dose response relationship (DRR) for the hematopoietic (H) acute radiation syndrome (ARS) in the canine relative to radiation quality of mixed neutron:gamma radiations, dose rate, and exposure uniformity relative to selected reference radiation exposure has not been performed. The datasets for rhesus macaques exposure to mixed neutron:gamma radiation are used herein as a species comparative reference to the canine database. The selection of data cohorts was made from the following sources: Ovid Medline (1957–present), PubMed (1954–present), AGRICOLA (1976–present), Web of Science (1954–present), and US HHS RePORT (2002–present). The total number of hits across all search sites was 3,077. Several referenced, unpublished, non-peer reviewed government reports were unavailable for review. Primary published studies using canines, beagles, and mongrels were evaluated to provide an informative and consistent review of mixed neutron:gamma radiation effects to establish the DRRs for the H-ARS. Secondary and tertiary studies provided additional information on the hematologic response or the effects on hematopoietic progenitor cells, radiation dosimetry, absorbed dose, and organ dose. The LD50/30 values varied with neutron quality, exposure aspect, and mixed neutron:gamma ratio. The reference radiation quality varied from 250 kVp or 1–2 MeV x radiation and 60Co gamma radiation. A summary of a published review of a data set describing the DRR in rhesus macaques for mixed neutron:gamma radiation exposure in the H-ARS is included for a comparative reference to the canine dataset. The available evidence provided a reliable and extensive database that characterized the DRR for the H-ARS in canines and young rhesus macaques exposed to mixed neutron:gamma radiations of variable energy relative to 250 kVp, 1–2 MeV x radiation and 60Co gamma, and uniform and non-uniform total-body irradiation without the benefit of medical management. The mixed neutron:gamma radiation showed an energy-dependent RBE of ~ 1.0 to 2.0 relative to reference radiation exposure within both species. A marginal database described the DRR for the gastrointestinal (GI)-ARS. Medical management showed benefit in both species relative to the mixed neutron:gamma as well as exposure to reference radiation. The DRR for the H-ARS was characterized by steep slopes and relative LD50/30 values that reflected the radiation quality, exposure aspect, and dose rate over a range in time from 1956–2012.
B Cells and Tertiary Lymphoid Structures Influence Survival in Lung Cancer Patients with Resectable Tumors

Simple Summary Nowadays, humans still die of lung cancer (LC), a disease mainly related to cigarette smoking (CS). Smokers also develop chronic bronchitis, namely chronic obstructive pulmonary disease (COPD). Environmental factors and a natural predisposition from the patients’ sides may render them more prone to develop tumors derived from CS. Thus, a great number of patients may suffer from chronic bronchitis and LC simultaneously. Chronic respiratory diseases are also important risks factors for LC. The immune system, among other biological mechanisms, protect our cells from infections and cancer development. Several immune structures and cells may be altered in the tumors of patients with COPD as opposed to lung tumors of patients with no underlying respiratory disease. A total of 133 patients with LC participated in the study: 93 with underlying COPD. Several structures (tertiary lymphoid structures, TLS) and T and B lymphocytes were analyzed in the lung tumor and non-tumor areas (specimens obtained during surgical extirpation of the tumors). We found that in LC patients with COPD, compared to those without it, fewer numbers of TLSs and B cells were detected, and those patients died significantly earlier. These results have implications in the diagnosis and treatment options of lung tumors in patients with underlying respiratory diseases. Abstract Immune profile of B and T cells and tertiary lymphoid structures (TLSs) may differ in tumors of lung cancer (LC) patients with/without chronic obstructive pulmonary disease (COPD), and may also influence patient survival. We sought to analyze: (1) TLSs, germinal centers (GCs), B and T cells, and (2) associations of the immune biomarkers with the patients’ 10-year overall survival (OS). TLSs (numbers and area), B [cluster of differentiation (CD) 20], and T (CD3), and GCs cells were identified in both tumor and non-tumor specimens (thoracotomy) from 90 LC-COPD patients and 43 LC-only patients. Ten-year OS was analyzed in the patients. Immune profile in tumors of LC-COPD versus LC: TLS numbers and areas significantly decreased in tumors of LC-COPD compared to LC patients. No significant differences were observed in tumors between LC-COPD and LC patients for B or T cells. Immune profile in tumors versus non-tumor specimens: TLS areas and B cells significantly increased, T cells significantly decreased in tumors of both LC and LC-COPD patients. Survival: in LC-COPD patients: greater area of TLSs and proportion of B cells were associated with longer survival rates. The immune tumor microenvironment differs in patients with underlying COPD and these different phenotypes may eventually impact the response to immunotherapy in patients with LC.