Miracle-dz/UniFAR-FTUs huggingface dataset:
Coronin 1c and F-actin Promote Metastasis of Breast Cancer

Background We studies the expression of Coronin 1c and F-actin protein in breast cancer and explored their relationship with breast cancer metastasis. Material/Methods A total of 210 breast cancer tissues and adjacent normal tissues were collected from January 2013 to December 2014. The expressions of Coronin 1c and F-actin were detected by immunohistochemistry and Western blotting. We analyzed the relationship between Coronin 1c and F-actin and clinical data of breast cancer. Results The expressions of Coronin 1c and F-actin in breast cancer tissues were positively correlated (r=0.926, P<0.05) and were significantly higher than those in normal tissues (P<0.05). The Coronin 1c and F-actin expressions were not correlated with age, tumor size, ER expression, or PR expression in breast cancer patients (P>0.05), but were significantly correlated with HER-2 expression, histological grade, lymph node metastasis, molecular classification, and TNM (P<0.05). The expression of HER-2 in breast cancer tissues was positively correlated with the expression of Coronin 1c (r=0.706, P<0.05) and F-actin 1c, while F-actin protein in breast cancer tissues with lymph node metastasis was significantly higher than in those without lymph node metastasis (P<0.05). Conclusions Coronin 1c protein and F-actin protein are highly expressed in breast cancer and their expression may be related to the metastasis of breast cancer cells.
Sliding-Mode Control of the Active Suspension System with the Dynamics of a Hydraulic Actuator

An improved model of the active suspension system is proposed. Compared with the existing model of active suspension system, the dynamics of a hydraulic actuator in the active suspension system is fully considered in the proposed model. Based on the proposed model, a sliding-mode control method is designed to control the active suspension system. Stability proof and analysis of the closed-loop system of the active suspension is given by using Lyapunov stability theory. At last, the reliability and feasibility of the proposed sliding-mode control method are evaluated by computer simulation. Simulation research shows that the proposed sliding-mode control method can obtain good control performance for the active suspension system.
Internet of Bikes: A DTN Protocol with Data Aggregation for Urban Data Collection

Intelligent Transport Systems (ITS) are an essential part of the global world. They play a substantial role for facing many issues such as traffic jams, high accident rates, unhealthy lifestyles, air pollution, etc. Public bike sharing system is one part of ITS and can be used to collect data from mobiles devices. In this paper, we propose an efficient, “Internet of Bikes”, IoB-DTN routing protocol based on data aggregation which applies the Delay Tolerant Network (DTN) paradigm to Internet of Things (IoT) applications running data collection on urban bike sharing system based sensor network. We propose and evaluate three variants of IoB-DTN: IoB based on spatial aggregation (IoB-SA), IoB based on temporal aggregation (IoB-TA) and IoB based on spatiotemporal aggregation (IoB-STA). The simulation results show that the three variants offer the best performances regarding several metrics, comparing to IoB-DTN without aggregation and the low-power long-range technology, LoRa type. In an urban application, the choice of the type of which variant of IoB should be used depends on the sensed values.
Micellar Liquid Chromatographic Determination of Idrocilamide in Dosage Form and Biological Fluids: Application to Stability Study

A simple, stability-indicating, reversed phase high perfomance liquid chromatographic method was developed and validated for the determination of idrocilamide in the presence of its degradation products . The separation was conducted using A Hibar C18 (150 × 4.6 mm i.d ) stainless steel column at ambient temperature with UV detection at 277 nm . Micellar mobile phase consisted of 0.1 M sodium dodecyl sulphate, 10% n-propanol, 0.3 % triethylamine in 0.02 M phosphoric acid (pH 6) was used and pumped at a flow rate of 1 mL/min . The calibration curve was rectilinear over the concentration range of 1-10 μg/mL with a detection limit of 0.1 μg /mL and quantification limit of 0.3 μg/mL . The proposed method was successfully applied to the analysis of idrocilamide in commercial cream with mean % recovery of 100.74 ± 0.93. The method was extended to the in-vitro determination of idrocilamide in spiked human plasma and urine samples with mean % recoveries of 99.93 ± 0.31 and 100.1 ± 0.26 respectively Moreover, the method was utilized to investigate the kinetics of both acid and alkaline induced degradation of the drug . The apparent first –order rate constant, half life time and activation energies of the degradation reactions were calculated
Detecting Diabetes Risk from Social Media Activity

This work explores the detection of individuals’ risk of type 2 diabetes mellitus (T2DM) directly from their social media (Twitter) activity. Our approach extends a deep learning architecture with several contributions: following previous observations that language use differs by gender, it captures and uses gender information through domain adaptation; it captures recency of posts under the hypothesis that more recent posts are more representative of an individual’s current risk status; and, lastly, it demonstrates that in this scenario where activity factors are sparsely represented in the data, a bag-of-word neural network model using custom dictionaries of food and activity words performs better than other neural sequence models. Our best model, which incorporates all these contributions, achieves a risk-detection F1 of 41.9, considerably higher than the baseline rate (36.9).
Who is more Food Secure among Rural, Peri-urban and Urban Households in Pakistan? Results from a field survey in Punjab province

This study aims to assess food security status of rural, peri-urban and urban households and role of socio-economic factors in ensuring food security. A survey was conducted to collect primary (quantitative) data from 630 respondents using proportionate sampling technique from Punjab, Pakistan. Cronbach’s Alpha reveals stability (>0.75) of data scale items. Using Dietary Intake Assessment (DIA), findings reveal urban households as highly food-secure whereas rural household as most vulnerable to food security at 2450kcal/day per person. Study indicates food price increase as the leading factor in preventing food security among households. Contrary, study identifies risk factors associated to food quality under the abundant availability and access as the new dimension to household food insecurity. Further, results of binary logit model show that socio-economic factors such as monthly income, total number of earners, education of household head and access to market are positively related with food security status whereas, social isolation, volatility in food prices and risk factors in food quality are negatively related with household food security. Therefore, study proposes educational orientation and entrepreneurial development as sustainable solution to ensure food security among masses. Besides, further country level researches are advised to deep delve the mounting menace of food security.
The WRKY Transcription Factor Family in Model Plants and Crops

ABSTRACT The WRKY gene family in flowering plants encodes a large group of transcription factors (TFs) that play essential roles in diverse stress responses, developmental, and physiological processes. In this review, we provided a comprehensive screenshot about the studies on WRKY TFs in model plants and in crops of economical relevance. Specifically, we discussed the history of discovery and functional characterization, classification, and evolutionary history, 3D structure and physiological functions of WRKY transcription factors. Based on the previous functional studies of WRKY genes in model plants such as Arabidopsis and rice, we summarized various roles of WRKY TFs in a broad range of biological processes as well as their degradation process. We also discussed the characterization and functional studies of WRKY TFs in important crops. Considering the rapid progress of high-throughput techniques, especially genomics and transcriptomics, which have been instrumental in advancing our understanding of the crop genomes, we comment one-by-one on the applications of a suite of new and high-throughput techniques to accelerate the studies of WRKY genes in crops.
Recycling of E-cadherin: a potential mechanism for regulating cadherin dynamics.

E-Cadherin plays critical roles in many aspects of cell adhesion, epithelial development, and the establishment and maintenance of epithelial polarity. The fate of E-cadherin once it is delivered to the basolateral cell surface, and the mechanisms which govern its participation in adherens junctions, are not well understood. Using surface biotinylation and recycling assays, we observed that some of the cell surface E-cadherin is actively internalized and is then recycled back to the plasma membrane. The pool of E-cadherin undergoing endocytosis and recycling was markedly increased in cells without stable cell-cell contacts, i.e., in preconfluent cells and after cell contacts were disrupted by depletion of extracellular Ca2+, suggesting that endocytic trafficking of E-cadherin is regulated by cell-cell contact. The reformation of cell junctions after replacement of Ca2+ was then found to be inhibited when recycling of endocytosed E-cadherin was disrupted by bafilomycin treatment. The endocytosis and recycling of E-cadherin and of the transferrin receptor were similarly inhibited by potassium depletion and by bafilomycin treatment, and both proteins were accumulated in intracellular compartments by an 18°C temperature block, suggesting that endocytosis may occur via a clathrin-mediated pathway. We conclude that a pool of surface E-cadherin is constantly trafficked through an endocytic, recycling pathway and that this may provide a mechanism for regulating the availability of E-cadherin for junction formation in development, tissue remodeling, and tumorigenesis.
Landscape and anthropogenic effects on mammal occupancy in the Appalachian Trail corridor

Anthropogenic effects on wildlife are typically assessed at the local level, but it is often difficult to extrapolate to larger spatial extents. Macro-level occupancy studies are one way to assess impacts of multiple disturbance factors that might vary over different geographic extents. Here we assess anthropogenic effects on occupancy and distribution for several mammal species within the Appalachian Trail (AT), a forest corridor that extends across a broad section of the eastern United States. Utilizing camera traps and a large volunteer network of citizen scientists, we were able to sample 447 sites along a 1024 km section of the AT to assess the effects of available habitat, hunting, recreation, and roads on eight mammal species. Occupancy modeling revealed the importance of available forest to all species except opossums (Didelphis virginiana) and coyotes (Canis latrans). Hunting on adjoining lands was the second strongest predictor of occupancy for three mammal species, negatively influencing black bears (Ursus americanus) and bobcats (Lynx rufus), while positively influencing raccoons (Procyon lotor). Modeling also indicated an avoidance of high trail use areas by bears and proclivity towards high use areas by red fox (Vulpes vulpes). Roads had the lowest predictive power on species occupancy within the corridor and were only significant for deer. The occupancy models stress the importance of compounding direct and indirect
Third-order dispersion in a passively mode-locked continuous-wave dye laser

The pulse duration tp of a colliding-pulse mode-locked dye laser is measured versus the intracavity third-order dispersion (TOD), where the group-velocity dispersion is optimized by a four-prism sequence. The intracavity TOD is varied by the addition of layers on quarter-wave dielectric-multilayer mirrors. The shortest pulse is observed at a nonzero TOD. The TOD dependence of tp is explained by a new model that describes the saturation of absorption and gain dyes in the frequency domain, with the assumption of a steady sech2-shaped pulse with weak chirp and a negligible fast self-phase modulation.
An empirical comparison of VerbNet syntactic frames and the Semlink corpus

Feely, Weston Richard (M.A., Linguistics, Department of Linguistics) An Empirical Comparison of VerbNet Syntactic Frames and the Semlink Corpus Thesis directed by Professor Martha Palmer This paper describes a method of automatically comparing syntactic frames from the verb lexicon VerbNet with syntactic frames from the Semlink corpus. A method of extracting syntactic frames and semantic argument structures is explained, followed by a method of comparing syntactic frames, both directly and by argument structure. The results of the comparison are described in terms of matching success for frame tokens and frame types, divided into categories based on frame type frequency within Semlink. Overall, 54.14% of the frame tokens within Semlink can be directly matched to VerbNet, with an additional 14.32% matching by argument structure. However, only 29.30% of the frame types within Semlink can be matched to VerbNet, suggesting that the comparison method cannot match a majority of the large variation of frames types in Semlink. A set of distinguishing frame types for VerbNet classes is also proposed and included in this work.
DESIGN OF WIDEBAND QUAD-RIDGED WAVEGUIDE ORTHOMODE TRANSDUCER AT L-BAND

In this paper, an L-band wideband quad-ridged waveguide orthomode transducer (OMT) for the Five hundred meter Aperture Spherical radio Telescope (FAST) is presented with a simple design principle. By designing two critical parts of the OMT separately and introducing matching rings into two orthogonal probes, an improved wideband performance has been realized successfully. The OMT is designed to operate across the 0.95 GHz–1.9 GHz band, and the simulation shows a return loss better than −20 dB for both polarizations, cross-polarized isolation levels over 45 dB and insertion loss lower than 0.15 dB over the entire bandwidth. The measured results are in good agreement with the simulations.
Seven-Year Ssm/I-Derived Global Ocean Surface Turbulent Fluxes

A 7.5-year (July 1987-December 1994) dataset of daily surface specific humidity and turbulent fluxes (momentum, latent heat, and sensible heat) over global oceans has been retrieved from the Special Sensor Microwave/Imager (SSM/I) data and other data. It has a spatial resolution of 2.0 deg.x 2.5 deg. latitude-longitude. The retrieved surface specific humidity is generally accurate over global oceans as validated against the collocated radiosonde observations. The retrieved daily wind stresses and latent heat fluxes show useful accuracy as verified by those measured by the RV Moana Wave and IMET buoy in the western equatorial Pacific. The derived turbulent fluxes and input variables are also found to agree generally with the global distributions of annual-and seasonal-means of those based on 4-year (1990-93) comprehensive ocean-atmosphere data set (COADS) with adjustment in wind speeds and other climatological studies. The COADS has collected the most complete surface marine observations, mainly from merchant ships. However, ship measurements generally have poor accuracy, and variable spatial coverages. Significant differences between the retrieved and COADS-based are found in some areas of the tropical and southern extratropical oceans, reflecting the paucity of ship observations outside the northern extratropical oceans. Averaged over the global oceans, the retrieved wind stress is smaller but the latent heat flux is larger than those based on COADS. The former is suggested to be mainly due to overestimation of the adjusted ship-estimated wind speeds (depending on sea states), while the latter is suggested to be mainly due to overestimation of ship-measured dew point temperatures. The study suggests that the SSM/I-derived turbulent fluxes can be used for climate studies and coupled model validations.
Children with Disabilities Algorithm Section 1 . Basic Measure Information 1

1.C. Measure Description Please provide a non-technical description of the measure that conveys what it measures to a broad audience. The Children with Disabilities Algorithm (CWDA) identifies International Classification of Diseases, Ninth Revision, Clinical Modification (referred to hereafter as ICD-9-CM) codes that were assessed by expert reviewers as having a 75 percent or greater likelihood of indicating children with disabilities (CWD). With this tool, it will be possible to identify children with a high probability of having a disability in order to:
The Role Of Erythropoietin In The Treatment Of Anemia In Patients With Malignant Lymphoma

Abstract Introduction: Anemia is a common complication of malignant lymphomas, which could be a direct consequence of the disease or secondary to the myelosupressive chemotherapy. The aim of this study was to assess the effect of erythropoietin to treat anemia. The main objectives were to demonstrate increases in hemoglobin levels and the existence of an association between symptom relief and treatment. Material and method: In the Clinical Hematology and BMT Unit Tîrgu Mureș we performed an analytical, observational study to assess the role of erythropoietin treatment in malignant lymphoma related anemia. This linear, retrospective study included 127 patients diagnosed and treated with malignant lymphoma between January 1st, 2007 and December 30, 2011. The 127 patients were divided into two groups: a group of patients (n = 88) who were treated with erythropoietin and the other group (n = 39) who did not receive this treatment. Patients included in the study received treatment with epoetin beta 40,000 IU/week. We followed the hemoglobin level and the symptomatology at baseline and after 4 weeks. Results: Patients who received treatment with erythropoietin had a 7.12 times higher possibility of being asymptomatic than patients who did not receive this treatment. The hemoglobin concentration of patients with erythropoietin treatment increased significantly (p <0.0001) compared to the patients who did not receive this treatment. Conclusion: Effective treatment of anemia is an important aim in the management of patients with malignant lymphomas, because it increases their hemoglobin concentration, decreases the need of transfusion and maintains an acceptable quality of life.
Nightmares and Associations with Sleep Quality and Self-Efficacy among University Students

Sleep problems are a common complaint among adults. In university students international studies showed prevalence rates between 4.7 and 36.2% for sleep difficulties and 2-3% of students report nightmares. Previous studies show that nightmares are often associated with insomnia and mental strain, but also with gender. The goal of this study was to outline nightmares, associations with sleep disturbances and mental strain as well as self-efficacy among university students. An amount of 2196 students (70.9% women; mean age 24.16 years) participated in the study. Sleep characteristics, nightmares, mental strain and self-efficacy were assessed by self-report questionnaires. Analyses revealed that more than 24.3% of surveyed students suffered from nightmares, 18.5% reported nightmares more often than once a week and 5.8% suffered from nightmares at least 3 times a week. Moreover, nightmares were associated with symptoms of insomnia and low self-efficacy was significantly associated with an increased rate of nightmares. Besides, a total of 52% of students reported fitful sleep.
Recent Topics in Protein Folding

The protein folding is a long-standing problem and there have been a lot of experimental and theoretical/computational studies so far [1-3]. These efforts by many researches have reveals mysterious folding mechanisms of proteins. However, there are still several unsolved problems on protein folding. An interesting one is how the information of the folding mechanism of a protein is encoded in its amino acid sequence. In the present short article, I discuss the remaining interesting problems on protein folding.
1-5 SEQUENTIALLY PARTITIONED POPULATION ATTRIBUTABLE FRACTION AS AN ESTIMATE OF IMPACT OF TICK PRESENCE ON INFECTION

#Corresponding author: mwangigachohi@gmail.com 2Department of Public Health, Pharmacology and Toxicology, University of Nairobi, P.O. Box 29053-00625,Nairobi, 3Biosciences Eastern and Central Africa (BecA) – ILRI Hub, P.O. Box 30709-00 00, ABSTRACT The impact of Rhipicephalus appendiculatus tick presence (exposure) on Theileria parva infection seroprevalence (outcome) on a farm was assessed in a group of cattle using population attributable fractions (PAF). The analysis was based on a representative sample of 80 traditional smallholder mixed farms from Mbeere District, Kenya. The PAFs were estimated using sequentially partitioned PAF approach that estimated a PAF associated with the exposure after adjusting for any effect that the confounder (agro-ecological zone [AEZ]) may have had by influencing the prevalence of the exposure. The resultant PAF was compared with Bruzzi approach PAF that estimated the proportion of T. parva infection cases directly attributable to the exposure after controlling for confounding by AEZ. The estimated PAF on the Bruzzi approach was 26.4% [95% CI: 9.6%, 43.2%]) whereas the partitioned PAF was 5.5% [95% CI: . 5%, 29.6%]) implying that about % of the estimated impacts was driven by AEZ effects. Both approaches were consistent in estimating a relatively low impact of farm vector tick presence with a relatively high level of uncertainty. Overall, the results suggested that under endemic instability in Mbeere District, ( ) presence of R. appendiculatus was not a good indicator of T. parva infection occurrence on a farm, and (2) ecological variation could play a role in determining infection impacts. This study provides a preliminary basis for evaluating the potential value of estimating PAFs for variables amenable to control in tick-borne diseases epidemiological studies.
Environmental analysis of gasoline blending components through their life cycle

The contributions of three major gasoline blending components (reformate, alkylate and cracked gasoline) to potential environmental impacts (PEI) are assessed. This study estimates losses of the gasoline blending components due to evaporation and leaks through their life cycle, from petroleum refining to vehicle refuelling. A sensitivity analysis is performed using different weighting factors for each potential environmental impact category, in order to assess the effect of each blending component on the total potential environmental impacts. The results indicate that reformate and cracked gasoline mainly contribute to photochemical oxidation followed by aquatic toxicity, terrestrial toxicity and human toxicity by ingestion. On the other hand, alkylate contributes mostly to aquatic toxicity but very little to photochemical oxidation. From the sensitivity analysis, a high weighting on the impact categories for aquatic toxicity, terrestrial toxicity and human toxicity by ingestion leads to alkylate having the largest potential impacts of the three blending components, whereas other combinations of weighting factors indicate that alkylate has the lowest potential impacts. 2003 Elsevier Ltd. All rights reserved.