Miracle-dz/UniFAR-FTUs huggingface dataset:
Intellectual Capacity of Children Exposed to Environmental Pollution in the Extreme South of Brazil

Objective: The study evaluated the intellectual capacity of children who live in areas that were E (exposed) or NE (not exposed) to environmental pollution. Method: 246 students between the ages of 8 and 11 years and 8 months were evaluated. Data were collected between May and June 2010 using a semi-structured questionnaire to examine factors that were related to compromised intellectual capacity. Intellectual capacity was evaluated with Raven’s Colored Progressive Matrices Scale. The intellectual capacity of children who live in areas that were exposed or not exposed was compared using chi-squared tests and raw and adjusted analyses were conducted using Poisson regression. Results: The general occurrence of intellectual impairment was 28.9%, with 22.0% in the non-exposed area and 36.1% in the exposed area (p = 0.01). The outcome was associated with the following: a lack of companionship (RP = 2.77; p < 0.00), maternal education of less than five years (RP = 2.13; p < 0.00), the mother not being Caucasian (RP = 1.57; p < 0.00), residing in an exposed area (RP = 1.88; p < 0.00), and nutritional risk/malnutrition (RP = 2.83; p < 0.00). Conclusions: The results showed a high occurrence of intellectual impairment and a significant difference between the environmental areas. Additional research is needed to improve the understanding of several results. The town’s priorities should include efforts related to environmental health.
E2F1 induces apoptosis and sensitizes human lung adenocarcinoma cells to death-receptor-mediated apoptosis through specific downregulation of c- FLIP short Running title: E2F1 targets c-FLIP S to induce apoptosis

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. E2F1 induces apoptosis and sensitizes human lung adenocarcinoma cells to death-receptor-mediated apoptosis through specific downregulation of cFLIP short Running title: E2F1 targets c-FLIP S to induce apoptosis Caroline Salon, Béatrice Eymin, Olivier Micheau, Laurence Chaperot, Joël Plumas, Christian Brambilla, Elisabeth Brambilla, Sylvie Gazzeri
Determination of phytochemical compounds in chicken breast by gas chromatography-tandem mass spectrometry

A gas chromatography-tandem mass spectrometry (GC-MS/MS) method was developed for the simultaneous detection and quantification of five phytogenic compounds (carvone, menthol, thymol, carvacrol and methyl salicylate) in chicken breast. Chicken breast samples were analyzed using a QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) approach using acetonitrile as extraction solvent, followed by a d-SPE (dispersive-solid phase extraction) clean up step. The linearities for the 5 substances were studied in the range between 2 and 100 μg/L and the coefficients of determination (R2) were always > 0.995. Matrix effects were also assessed by comparing the slopes obtained in solvent and chicken breast matrix. The recoveries for all the substances at 3 different spike levels (5, 10 and 50 μg/kg) were in the range 80–102% with RSDs < 15%. The instrumental limits of quantification were in the range 2.7–4.8 μg/kg, while the reporting level of the method was 5 μg/kg for all the aforementioned compounds. The method was successfully applied to 10 chicken breasts samples from the local market.
Real roots of random polynomials with coefficients of polynomial growth: a comparison principle and applications*

This paper seeks to further explore the distribution of the real roots of random polynomials with non-centered coefficients. We focus on polynomials where the typical values of the coefficients have power growth and count the average number of real zeros. Almost all previous results require coefficients with zero mean, and it is nontrivial to extend these results to the general case. Our approach is based on a novel comparison principle that reduces the general situation to the mean-zero setting. As applications, we obtain new results for the Kac polynomials, hyperbolic random polynomials, their derivatives, and generalizations of these polynomials. The proof features new logarithmic integrability estimates for random polynomials (both local and global) and fairly sharp estimates for the local number of real zeros.
Automated Reference Model Generation and Utilization for Dimensional Control of Large Scale Assemblies and Assembly Processes

—A lot of manual user interaction with computer aided design and analysis software is currently needed for dimensional control of large scale assemblies. This user input is required for both selecting the vital entities to be measured and analyzing the results of the measurements. In this paper an automated approach for reference model generation and vital entity selection is presented. The reference model generation is guided by user editable knowledge base and it is based on data extraction from computer aided design data. Prospects to utilize the generated reference model for automated manufacturing accuracy analysis are also outlined. The software implementation made has proved to be feasible for different kinds of dimensional control needs of large scale assemblies, and outweighs the current state of the art both in speed, completeness, and versatility.
Discovery and Development of New Antibiotics : the Problem of Antibiotic Resistancet

Real clinical needs for new antimicrobial antibiotics derive from the emergence and dissemination of new opportunistic pathogens, especially in a growing immune system-debilitated host population. The significant health problems that occur as a result of infections with these rare or opportunistic pathogens is an outgrowth of the AIDS epidemic as well as the increasing prevalence of aggressive cancer chemotherapy and organ transplantation. Therapeutic needs can often be met by optimizing the use of existing chemotherapeutic agents. However, commonly prescribed antibiotics may not sufficiently cover these organisms, and the rapid spread or development of antibiotic resistance may compromise standard empiric treatment. Indeed, the greatest threat to successful antibiotic coverage, and hence the driving force behind the search for new therapies, is the evolution and spread of antibiotic resistance. Resistance of common or resurgent pathogens to standard antibiotic therapies is a significant nosocomial problem and is of increasing importance in communityacquired infections as well. In the hospital setting, especially tertiary-care facilities (40), the incidence of drug-resistant gram-positive infections is increasing-notably among Staphylococcus aureus, coagulase-negative staphylococci, corynebacteria, and enterococci-while drug resistance in gram-negative organisms, including Pseudomonas, Serratia, andAcinetobacter species, continues to pose problems (20). The recent appearance of virulent strains of Mycobactenum tuberculosis that are resistant to multiple antibiotics in the AIDS, illegal drug addict, and prison populations has caused great alarm, posing a threat to the wider community and a potential resurgence of the disease (1). Empiric therapy favors the use and hence the development of broad-spectrum agents and combinations (7), even though the underlying need may be for treatment of specific problem pathogens, such as Pseudomonas species or methicillin-resistant staphylococci. While future technological refinements may bring rapid diagnostic methods and lead to effective dosing with narrow-spectrum agents, the current strategy is to develop antibiotics with good pharmacological profiles and (relatively) broad spectra of activity, including activity against the problem pathogens. The effective spectrum of an antibiotic, for empirical dosing, is determined by the MIC for 90% of strains tested, which, when it is based on
Contrôle robuste d’un laminoir à chaud

Résumé—Dans cet article, nous proposons un régulateur robuste H2 capable de garantir la stabilité d’un laminoir à chaud et d’améliorer ses performances. L’objectif principal du processus de laminage est d’obtenir des tôles métalliques avec l’épaisseur désirée. Le décentrement de la tôle par rapport à l’axe de laminage peut dégrader la qualité du produit voire endommager le système de production. L’objectif est de réduire ce décentrement. Comme un laminoir travaille avec des produits qui peuvent avoir des caractéristiques très différentes, nous avons créé une base de données qui décrit l’ensemble des produits traités et nous l’avons divisée en plusieurs familles de produits. Nous décrivons une méthode pour réduire la complexité du problème en exploitant les relations physiques entre les paramètres. Cette méthode permet de formuler le problème de stabilisation comme un problème convexe et, par conséquent, de synthétiser un régulateur H2 différent pour chaque famille de produits. Nous présentons aussi les résultats expérimentaux obtenus sur le laminoir d’ArcelorMittal situé à Eisenhüttenstadt.
Cloning and Functional Characterization of a Phospholipid:Diacylglycerol Acyltransferase from Arabidopsis

Department of Crop Science, Swedish University of Agricultural Sciences, S–230 53 Alnarp, Sweden (A.S.C., A.B., S.S.); Department of Plant Biology and Forest Genetics, Uppsala Genetic Centre, Swedish University of Agricultural Sciences, S–750 07 Uppsala, Sweden (U.S.); Scandinavian Biotechnology Research (ScanBi) AB, S–230 53 Alnarp, Sweden (M.L., A.D.); Institute of Biology, University of Podlasie, 08–110, Siedlce, Poland (W.B); and College of Life Science, Hubei University, Wuhan, 430062, P.R. China (B.H.)
Transgenic loblolly pine (Pinus taeda L.) plants expressing a modi®ed d-endotoxin gene of Bacillus thuringiensis with enhanced resistance to Dendrolimus punctatus Walker and Crypyothelea

A synthetic version of the CRY1Ac gene of Bacillus thuringiensis has been used for the transformation of loblolly pine (Pinus taeda L.) using particle bombardment. Mature zygotic embryos were used to be bombarded and to generate organogenic callus and transgenic regenerated plants. Expression vector pB48.215 DNA contained a synthetic Bacillus thuringiensis (B.t.) CRY1Ac coding sequence ̄anked by the double cauli ̄ower mosaic virus (CaMV) 35S promoter and nopaline synthase (NOS) terminator sequences, and the neomycin phosphotransferase II (NPTII) gene controlled by the promoter of the nopaline synthase gene was introduced into loblolly pine tissues by particle bombardment. The transformed tissues were proliferated and selected on media with kanamycin. Shoot regeneration was induced from the kanamycin-resistant calli, and transgenic plantlets were then produced. More than 60 transformed plants from independent transformation events were obtained for each loblolly pine genotype tested. The integration and expression of the introduced genes in the transgenic loblolly pine plants was con®rmed by polymerase chain reactions (PCR) analysis, by Southern hybridization, by Northern blot analysis, and by Western blot analysis. Effective resistance of transgenic plants against Dendrolimus punctatus Walker and Crypyothelea formosicola Staud was veri®ed in feeding bioassays with the insects. The transgenic plants recovered could represent a good opportunity to analyse the impact of genetic engineering of pine for sustainable resistance to pests using a B. thuringiensis insecticidal protein. This protocol enabled the routine transformation of loblolly pine plants that were previously dif®cult to
A Modular Intrusion Detection System based on Artificial Neural Networks

— This paper proposes a novel Intrusion Detection System (IDS) based on Artificial Neural Networks (ANNs). The proposed multi-ANN system is modular, parallel and easily expandable in order to detect additional types of attacks. Three types of attacks have been tested so far: DDoS, PortScan and Web attacks. The experimental results obtained by analyzing and testing the proposed IDS using the CICIDS2017 dataset, show satisfactory performance and superiority in terms of accuracy, detection rate, false alarm rate and time overhead compared to existing single-ANN systems.
SAFETY AND EFFICACY OF COMBINED ANTIBIOTIC AND PROBIOTIC THERAPY IN TREATMENT OF BACTERIAL VAGINOSIS

Background: Bacterial vaginosis is a common condition and the associated disease burden is rising every year. As successful as the traditional antibiotic is, supplementation with modern approach may help lessen the disease burden. One such approach is oral or vaginal instillation of probiotic which stems from the observed dominance of lactobacilli in healthy vaginal microbiota and its depletion in bacterial vaginosis (BV). Objective: To determine the safety and efficacy of combined antibiotic and probiotic therapy in the management of bacterial vaginosis. Methodology: This prospective cohort was conducted upon a sample of 100 premenopausal women diagnosed with BV. The study subjects were treated with oral metronidazole (500 mg) twice daily from days 1 to 7, and randomized to receive oral probiotic (lactobacillus) or placebo twice daily from days 1 to 30. Primary outcome was cure of BV as determined by normal Nugent score, negative sialidase test and no symptoms or signs of BV at day 30. The data obtained was recorded onto a structured questionnaire and analyzed using SPSS v.21 & Microsoft Excel 2016. Results: The mean age of the women mothers stood at 33 (SD ± 6). The success (achievement of cure of BV as determined by normal Nugent score, absence of clue cells, negative sialidase test, no symptoms or signs and no discharge or odor at day 30) rate of the treatment stood at 88% for the combined treatment group and 40% for the antibiotic/placebo group (p < 0.001). Conclusion: After careful consideration, it can be concluded that combined therapy is safe and more efficacious than lone antibiotic. Thus use of probiotics should be routinely employed for the treatment of BV.
Impact of the Entering Time on the Performance of MPI Collective Operations

—Collective operations strongly affect the performance of many MPI applications, as they involve large numbers, or frequently all, of the processes communicating with each other. One critical issue for the performance of collective operations is load imbalance, which causes processes to enter collective operations at different times. The inﬂuence of such late-arrivals is not well understood at the moment. Earlier work showed that even small system noise can have a tremendous effect on the collective performance. Thus, although algorithms are optimized for large process counts, they do not seem to tolerate noise or consider delay of involved processes and even a small perturbation from a single process can already have a negative effect on the overall collective execution. In this work, we show a ﬁrst detailed study about the effect of late arrivals onto the collective performance in MPI. For the evaluation a new, specialized benchmark was designed and a new metric, which we call delay overlap beneﬁt, was used. Our results show that there is already some potential tolerance to late arrivals for the most common collective operations - namely barrier, broadcast, allreduce and alltoall - but there is also a lot of room for future optimizations.
Second-moment and scalar flux representations in engineering and geophysical flows

Tensor and vector representations of velocity second-moments and the scalar fluxes have long been used in the closure of the transport equations describing the motion of turbulent flows. These representations are the turbulent models or parameterizations that have been the basis for extensive research in the Reynolds-averaged Navier–Stokes approach as well as other formulations resulting in transport equations for averaged flow variables. They have led to the development of improved nonlinear eddy viscosity, algebraic Reynolds stress models and algebraic scalar flux models. Over the last two decades, the process used in developing such closures has been formalized, and this has led to models and parameterizations capable of replicating more complex flow dynamics. The intent here is to provide the reader with a summary description of a procedure that can be followed to rationally construct such explicit representations from the full transport equations for both tensor and vector quantities in general, and the velocity second-moments and the heat fluxes in particular, applicable to both engineering and geophysical flows.
COPD_A_291554 933..943

1Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; 2Respiratory Therapy Area, GSK, Research Triangle Park, NC, USA; 3Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; 4R&D, GSK, Ware, Hertfordshire, UK; 5Global Medical Affairs, GSK, Brentford, Middlesex, UK; 6Institute for Lung Health, University of Leicester, Leicester, Leicestershire, UK; 7Department of Pulmonary and Critical Care Medicine, Kaiser Permanente Northwest Center for Health Research, Portland, OR, USA; 8Primary Care Research, University of Southampton, Southampton, UK; 9Biostatistics, GSK, Stockley Park West, Uxbridge, Middlesex, UK; 10Pulmonary Research, Institute of Southeast Michigan, Farmington Hills, MI, USA Background: The influence of peak inspiratory flow (PIF) on dose delivery from dry powder inhalers (DPIs) and association with treatment efficacy in patients with chronic obstructive pulmonary disease (COPD) has not been fully determined. In vitro studies have demonstrated adequate dose delivery through ELLIPTA DPI at PIF ≥30 L/min. This analysis of two clinical trials and a real-world population of COPD patients determined spirometric PIF distribution, and explored the relationship between PIF and outcomes in the trials. Methods: The replicate Phase IV, 12-week, randomized, double-blind 207608/207609 (NCT03478683/NCT03478696) trials evaluated fluticasone furoate/umeclidinium/vilanterol via ELLIPTA DPI versus budesonide/formoterol+tiotropium in COPD patients. This post hoc analysis assessed spirometric PIF distribution at screening and relationship between PIF and lung function outcomes in the pooled 207608/207609 population. Spirometric PIF distributions in a real-world population of COPD patients were evaluated by retrospective analysis of the Kaiser Permanente Northwest (KPNW) database to assess similarities between clinical trial and real-world populations. Results: A total of 1460 (207608/207609) and 3282 (KPNW) patients were included. There was considerable overlap between spirometric PIF distributions for both populations. Overall, 99.7% and 99.8% of the 207608/207609 and KPNW populations, respectively, reported spirometric PIF ≥50 L/min, estimated as equivalent to ELLIPTA PIFR ≥30 L/min. In the 207608/207609 combined analysis, there was no significant interaction between spirometric PIF and treatment for lung function endpoints, indicating treatment effect is independent of PIF. Conclusion: Nearly all COPD patients in the 207608/207609 and KPNW populations achieved spirometric PIF values estimated as equivalent to PIFR of ≥30 L/min through the ELLIPTA DPI. Lack of correlation between spirometric PIF at screening and treatment efficacy aligns with consistent dose performance from the ELLIPTA DPI across a wide range of PIFs, achieved by patients with COPD of all severities.
2015-3 Correlation, Consumption, Confusion, or Constraints: Why Do Poor Children Perform So Poorly?

The economic and social mobility of a generation may be largely determined by the time it enters school given early developing and persistent gaps in child achievement by family income and the importance of adolescent skill levels for educational attainment and lifetime earnings. After providing new evidence of important differences in early child investments by family income, we study four leading mechanisms thought to explain these gaps: an intergenerational correlation in ability, a consumption value of investment, information frictions, and credit constraints. In order to better determine which of these mechanisms influence family investments in children, we evaluate the extent to which these mechanisms also explain other important stylized facts related to the marginal returns on investments and the effects of parental income on child investments and skills.
Theoretical and Experimental Study of Lunar Dust Dynamics

: One of the most important problems on the Moon, reported during the Apollo missions, is lunar dust. Its surface is covered with a layer of very fine grains (20 µm and less), very abrasive which tend to stick on any surface, producing malfunction of devices, degradation of thermal control coatings or bad accuracy of measurements. These dusts were also observed to levitate above the lunar surface by astronauts and, thereby, generated a reduced visibility. It is therefore necessary to understand the physical mechanisms that govern this dynamics on the Moon and on asteroids by providing a physical model taking into account electrostatic charge phenomena, transport and adhesion of dust, stemming from interactions with the space environment and materials of interest for exploration systems. Consequently, it is required to know the environmental conditions favoring transport of particles to set up experiments. In this article, semi-analytical models of charged dust dynamics will be presented, based on literature data of the conditions over the Moon surface. We also present experimental investigations conducted in ONERA vacuum chamber in Toulouse. The main objective of this experimental study is to observe the levitation of dust grains as a function of key parameters: electric field, dust radius distribution, charging environments.
Tannins and Anthocyanins: From Their Origin to Wine Analysis – A Review

Anthocyanins and tannins are very important chemical compounds in the grape berry and the corresponding wine, as they greatly influence the colour, taste and maturation potential of the wine, as well as offer numerous health benefits. This review tries to establish the origin of anthocyanins and tannins by looking at metabolic pathways and attempting to establish a link between photosynthesis and the flavonoid biosynthetic pathway, the translocation thereof from leaves to berries, different methods to extract anthocyanins and tannins from wine and, in the end, the different analytical methods that can be used to analyse for anthocyanins and tannins.
Tensor approximation properties for multiresolution and multiscale volume visualization

: Interactive visualization and analysis of large and complex volume data is still a big challenge. Compression-domain volume rendering methods have shown that mathematical tools to represent and com- press large data are very successful. We use a new framework that is widely used for data approximation and tensor approximation (TA). Specific properties of the TA bases are elaborated in the context of multiresolution and multiscale volume visualization. A BSTRACT Interactive visualization and analysis of large and complex volume data is still a big challenge. Compression-domain volume rendering methods have shown that mathematical tools to represent and com- press large data are very successful. We use a new framework that is widely used for data approximation – tensor approximation (TA). Speciﬁc properties of the TA bases are elaborated in the context of multiresolution and multiscale volume visualization.