Miracle-dz/UniFAR-FTUs huggingface dataset:
175Yb-TTHMP as a good candidate for bone pain palliation and substitute of other radiopharmaceuticals

Bone metastasis is one of the most frequent causes of pain in cancer patients. Different radioisotopes such as P-32, Sm-153, Ho-166, Lu-177, and Re-186 with several chemical ligands as ethylenediaminetetramethylene phosphonic acid (EDTMP), 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene phosphonic acid (DOTMP), and propylenediaminetetramethylene phosphonate (PDTMP) are recommended for bone pain palliation. In this work, 175Yb-triethylenetetraminehexamethylene phosphonic acid (TTHMP) was produced as a proper alternative to other radiopharmaceuticals. Relatively long half-life (T1/2 = 4.18 days), maximum energy beta particle Eβ =470 keV (86.5%), low abundance gamma emission 396 keV (6.4%), 286 keV (3.01%), 113.8 keV (1.88%) and low cost are considered advantageous of Yb-175 are to wider usage of this isotope; in addition, TTHMP is an ideal carrier moiety for bone metastases. Production, quality control, and biodistribution studies of 175Yb-TTHMP were targeted. Yb-175 chloride was obtained by thermal neutron bombardment of a natural Yb2O3 sample at Tehran Research Reactor (TRR), radiolabeling was completed in 1 h by the addition of TTHMP at the room temperature and pH was 7.5-8, radiochemical purity was higher than 95%. Biodistribution studies in normal rats were carried out. The results showed favorable biodistribution features of 175Yb-TTHMP, indicating significant accumulation in bone tissues compared with clinically used bone-seeking radiopharmaceuticals. This research presents 175Yb-TTHMP can be a good candidate for bone pain palliation and substitute of other radiopharmaceuticals, however, further biological studies in other mammals are still needed.
Factors associated with undernutrition and overweight in elderly patients presenting at a primary care clinic in Nigeria

Abstract Background: Undernutrition and overweight are commonly overlooked health problems of the elderly, often due to the implicit assumption that undernutrition is a rare occurrence in old age and overweight is an invariable consequence of ageing. Method: A cross-sectional descriptive study of 500 patients aged 60 years and above who presented consecutively at the general outpatient department, University College Hospital, Ibadan, between September and October 2009, was undertaken. The main outcome measures were prevalence of nutritional problems (undernutrition and overweight), healthcare utilisation pattern and morbidities. The Mini Nutritional Assessment (MNA) tool was used to assess undernutrition, while body mass index was used to assess body weight. Results: The prevalence of undernutrition and overweight was 7.8% and 54.1%, respectively. Previous hospital admission (p < 0.001) and chronic morbidities like hypertension (p < 0.001), osteoarthritis (p < 0.001) and psychosomatic disease (p < 0.001) were significantly associated with undernutrition, but not with overweight. Logistic regression analysis showed that previous hospital admission (OR = 2.105, 95% CI 1.479–2.996) and hypertension (OR = 0.122, 95% CI 0.048–0.306) were the most important factors contributing to the development of undernutrition. Conclusion: Nutritional problems were prevalent among the elderly in this setting. Co-morbidities in the elderly constitute risk factors to be addressed in order to reduce the occurrence of nutritional problems. Health workers should always assess the elderly for nutritional problems, together with other morbidities with which they may present, and institute appropriate management.
Association of biofilm production with multidrug resistance among clinical isolates of Acinetobacter baumannii and Pseudomonas aeruginosa from intensive care unit

Background and Aims: Given choice, bacteria prefer a community-based, surface-bound colony to an individual existence. The inclination for bacteria to become surface bound is so ubiquitous in diverse ecosystems that it suggests a strong survival strategy and selective advantage for surface dwellers over their free-ranging counterparts. Virtually any surface, biotic or abiotic (animal, mineral, or vegetable) is suitable for bacterial colonization and biofilm formation. Thus, a biofilm is “a functional consortium of microorganisms organized within an extensive exopolymeric matrix. ” Materials and Methods: The present study was undertaken to detect biofilm production from the repertoire stocks of Acinetobacter baumannii (A. baumannii) and Pseudomonas aeruginosa (P. aeruginosa) obtained from clinical specimens. The tube method was performed to qualitatively detect biofilm production. Results: A total of 109 isolates of both organisms were included in the study, out of which 42% (46/109) isolates showed biofilm detection. Among the biofilm producers, 57% of P. aeruginosa and 73% of A. baumannii showed multidrug resistance (MDR) pattern which was statistically significant in comparison to nonbiofilm producers (P < 0.001). Conclusion: To the best of our knowledge, this is the only study to have tested the biofilm production in both P. aeruginosa and A. baumannii in a single study. Biofilm production and MDR pattern were found to be significantly higher in A. baumannii than P. aeruginosa. Antibiotic resistance was significantly higher among biofilm producing P. aeruginosa than non producers. Similarly, antibiotic resistance was significantly higher among biofilm producing A. baumannii than non producers.
IMPROVING MOUSE POINTING WITH EYE-GAZE TARGETING: APPLICATION IN RADIOLOGY

In current radiology workstations, a scroll mouse is typically used as the primary input device for navigating image slices and conducting operations on an image. Radiological analysis and diagnosis rely on careful observation and annotation of medical images. During analysis of 3D MRI and CT volumes thousands of mouse clicks are performed every day, which can cause wrist fatigue. This thesis presents a dynamic Control-to-Display (C-D) gain mouse movement method, controlled by an eye-gaze tracker as the target predictor. By adjusting the C-D gain according to the distance to the target, the target width in motor space is effectively enlarged, thus reducing the index of difficulty of the mouse movement. Results indicate that using eye-gaze to predict the target position, the dynamic C-D gain method can improve pointing performance and increase the accuracy over traditional mouse movement.
A classification of cranio facio cervical (branchial) clefts (Bangalore classification)

This new classification is based on the analysis of the following: 1. � The study of Embryological developments of the normal structures and the clefts in the head and neck regions, 2. � The Clinical presentation of Clefts in the head and neck regions in our series of 146 cases, 3. � The study of clefts under Rare craniofacial, Branchial [Cervical] and Classifications by various Authors and 4. The review of Literature pertaining to the clefts in head and neck regions. The documentation of commonly diagnosed and treated cleft lip and palate anomalies have remained unsatisfactory. As the regular cleft lip and palate falls within the purview of this new classification, a separate classification of Rare Craniofacial clefts can be avoided. This is an attempt made to bring all varieties of cleft deformities in the head and neck region under one Classification and to plan and execute better techniques in the field of assessment and management.
Provincial Healthcare Index 2013

The Fraser Institute’s Provincial Healthcare Index 2013 uses publicly available data for the year 2010 (or the most recent year available) to measure the provision of healthcare in comparison to healthcare expenditures across provinces in Canada. The value for money that provinces receive can be thought of as consisting of two, equally important parts: [1] provision of healthcare (the value) and [2] expenditure on healthcare (the cost). The provision of healthcare is captured using 46 indicators, aggregated into four broad components: [1] availability of resources; [2] use of resources; [3] access to resources; [4] clinical performance of medical goods and services in each province.
SLEEP QUALITY IN PROFESSIONAL BALLET DANCERS

Ballet dancers are competitive athletes who undergo extreme physical and mental stress and work according to an irregular schedule, with long days of training, rehearsal, and performance. Their most significant potential risks entail physical injury and altered sleep. The elaborate training requirements for ballet dancers do not allow regular chronobiological patterns or a normal sleep-wake rhythm. Our aim was to investigate the sleep-wake rhythm and sleep quality during rehearsal phases prior to a ballet premiere. We used wrist actigraphy and sleep diaries for a period of 67 days before the ballet premiere performance to study 24 classical ballet dancers. We likewise applied the Epworth Sleepiness Score (ESS), Pittsburgh Sleep Quality Index (PSQI), SF-12 Quality of life Assessment, and d2 Test of Attention to assess quality of sleep, aspects of cognitive performance, and health status. We found significant reduction in sleep duration, from 418 ± 43 min to 391 ± 42 min, and sleep efficiency, from 81 ± 4% to 79 ± 5%, over the 67-day course of the rehearsal. We also found a decline in time in bed and an increase in wakefulness after sleep onset. Sleep onset latency did not change. However, the changes in sleep as documented by actigraphy were not reflected by the subjective data of the sleep diaries and sleep scores. As a result of the facts that total sleep efficiency and sleep duration values were already lower than usual for the dancers’ age group at the beginning of the study and that mental acuity, concentration, and speed were likewise impaired, we observed exacerbated health deterioration in terms of sleep deprivation in ballet dancers during preparation for a premier. We conclude that individual activity-rest schedules, including daytime naps, may be helpful, especially during the stressful training and rehearsal experienced prior to ballet premieres. (Author correspondence: martin.glos@charite.de)
PARADOXICAL POST-EXERCISE RESPONSES OF ACYLATED GHRELIN AND LEPTIN DURING A SIMULATED NIGHT SHIFT

Approximately 10% of employees undertake night work, which is a significant predictor of weight gain, possibly because responses to activity and eating are altered at night. It is known that the appetite-related hormone, acylated ghrelin, is suppressed after an acute bout of exercise during the day, but no researcher has explored whether evening exercise alters acylated ghrelin and other appetite-related outcomes during a subsequent night shift. Six healthy men (mean ± SD: age 30 ± 8 yrs, body mass index 23.1 ± 1.1 kg/m2) completed two crossover trials (control and exercise) in random order. Participants fasted from 10:00 h, consumed a test meal at 18:00 h, and then cycled at 50% peak oxygen uptake or rested between 19:00–20:00 h. Participants then completed light activities during a simulated night shift which ended at 05:00 h. Two small isocaloric meals were consumed at 22:00 and 02:00 h. Venous blood samples were drawn via cannulation at 1 h intervals between 19:00–05:00 h for the determination of acylated ghrelin, leptin, insulin, glucose, triglyceride, and non-esterified fatty acids concentrations. Perceived hunger and wrist actimetry were also recorded. During the simulated night shift, mean ± SD acylated ghrelin concentration was 86.5 ± 40.8 pg/ml following exercise compared with 71.7 ± 37.7 pg/ml without prior exercise (p = 0.015). Throughout the night shift, leptin concentration was 263 ± 242 pg/ml following exercise compared with 187 ± 221 pg/ml without prior exercise (p = 0.017). Mean levels of insulin, triglyceride, non-esterified fatty acids, and wrist actimetry level were also higher during the night shift that followed exercise (p < 0.05). These data indicate that prior exercise increases acylated ghrelin and leptin concentrations during a subsequent simulated night shift. These findings differ from the known effects of exercise on acylated ghrelin and leptin during the day, and therefore have implications for energy balance during night work. (Author correspondence: c.j.morris@2006.ljmu.ac.uk).
GLIAL TRANSCRIPTS AND IMMUNE-CHALLENGED GLIA IN THE SUPRACHIASMATIC NUCLEUS OF YOUNG AND AGED MICE

Biological rhythms are frequently disturbed with advancing age, and aging-related changes of glia in the hypothalamic suprachiasmatic nucleus (SCN), the master circadian pacemaker, require special attention. In particular, astrocytes contribute to SCN function, and aging is associated with increased inflammatory activity in the brain, in which microglia could be especially implicated. On this basis, we investigated in the SCN of young and old mice glial transcripts and cell features, and the glial cell response to a central inflammatory challenge. Quantitative real-time reverse transcriptase–polymerase chain reaction (RT-PCR) was used to analyze the expression of mRNAs encoding the astrocytic glial fibrillary acidic protein and the microglial antigen CD11b. Both these transcripts, here investigated in the SCN for the first time, were significantly increased in the old SCN. Glial cell phenotyping with immunohistochemistry revealed hypertrophic and intensely stained astrocytes and microglia in the aged SCN. In both age groups, microglia were scattered throughout the SCN and astrocytes were prominent in the ventral portion, where retinal fibers are densest; in the aged SCN, astrocytes were also numerous in the dorsal portion. After intracerebroventricular injections of a mixture of interferon-γ and tumor necrosis factor-α, or phosphate-buffered saline as control, immunolabeling was evaluated with stereological cell counts and confocal microscopy. Phenotypic features of astrocyte and microglia activation in response to cytokine injections were markedly enhanced in the aged SCN. Subregional variations in glial cell density were also documented in the aged compared to the young SCN. Altogether, the findings show increases in the expression of glial transcripts and hypertrophy of astrocytes and microglia in the aged SCN, as well as age-dependent variation in the responses of immune-challenged SCN glia. The data thus point out an involvement of glia in aging-related changes of the biological clock. (Author correspondence: marina.bentivoglio@univr.it)
DAILY RHYTHMICITY OF ATTENTION IN MORNING- VS. EVENING-TYPE ADOLESCENTS AT BOARDING SCHOOL UNDER DIFFERENT PSYCHOSOCIOLOGICAL TESTING CONDITIONS

This study used a single protocol to investigate the respective and related effects of the psychosocial conditions of testing (individual vs. group) and personality on the levels and daily variation of attentional performance of adolescents attending boarding school. From scores obtained on an adapted version of Horne and Östberg's Morningness–Eveningness Questionnaire (MEQ), 17 male (9 morning-type and 8 evening-type) participants were selected from among 50 volunteers. Attention was measured using a number crossing-out test carried out at four times of the day (07:30, 12:00, 14:00, and 19:30). No main effect of testing mode and personality trait was found on the mean level of performance. Time-of-day had an effect on the level of performance, which differed depending on whether the test was administered in a group or individually and on the morningness and eveningness dimension. The difference between the daily profiles appears to be dependent on the interaction of the factors studied. This study investigated the concept of “group psychological rhythmicity” and highlights the importance of synchronizing social rhythms. (Author correspondence: rene.clarisse@univ-tours.fr)
Changing conceptions of practical skill and skill acquisition in nursing education

Changing conceptions of practical skill and skill acquisition in nursing education The learning of practical skill in nursing is not a priority of nursing education today. This is a result of a narrow and mechanistic concept of practical skill and its acquisition in nursing education. This paper reviews these conceptions as they have been developed in major textbooks for nurse teachers and in research articles on skill teaching, learning and evaluation over the past 50 years. Nursing research must move out of the laboratory and into the clinical setting in order to incorporate the typical aspects of practical skill learning in nursing. Future challenges in this kind of research are discussed.
Functional residual capacity tool: A practical method to assess lung volume changes during pulmonary complications in mechanically ventilated patients

In this report, we describe a patient in whom we used a functional residual capacity (FRC) tool available on a critical care ventilator to identify the loss of lung volume associated with pulmonary complications and increase in FRC with the application of a recruitment maneuver. The case report underlines the utility of the FRC tool in rapid visualization of the lung volume changes and the effects of application of corrective strategies in patients receiving mechanical ventilation.
Work, Aging, and Retirement in Australia: Introduction to the Special Issue

Australia has an aging population and workforce, and policy makers and organizations increasingly encourage older workers to remain on the job longer and even beyond traditional retirement age. After a brief review of important demographic and political developments, we introduce the 8 articles included in this special issue on work, aging, and retirement in Australia. The articles include an overview of the Australian retirement income system, 6 articles reporting quantitative analyses of cross-sectional and longitudinal data provided by large samples of Australian workers and retirees, and a qualitative study which analyzes interviews with human resource managers. Overall, the articles demonstrate that research on work, aging, and retirement in Australia is flourishing, sophisticated, and diverse both in terms of content and methodologies. We close with a brief review of topics and research questions related to work, aging, and retirement that remain to be addressed in the Australian context in future research.
Occupational Therapy Assessment of Self-Awareness following Traumatic Brain Injury

Impaired self-awareness is a common problem following traumatic brain injury. Without adequate self-awareness, a person's motivation to participate in rehabilitation may be limited, which in turn can have an adverse effect on his or her functional outcome. For this reason, it is important that brain injury rehabilitation professionals, including occupational therapists, both understand this phenomenon and use assessment and treatment approaches aimed at improving clients' self-awareness. This article provides an overview of self-awareness, reviewing the distinction between intellectual and online awareness. The current role of occupational therapy in the assessment of self-awareness is highlighted and the guidelines for new assessments of self-awareness suitable for use in occupational therapy are explored.
Mismatch Loss Reduction in Photovoltaic Arrays as a Result of Sorting Photovoltaic Modules by Max-Power Parameters

Variations in photovoltaic (PV) module current-voltage curves result in a power loss in PV arrays often referred to as mismatch loss (MML). As a means of reducing MML, newly fabricated PV modules are sorted to meet a set tolerance for variation in overall maximum power output with respect to a given module’s rated power. Starting with flash test data sets for two different polycrystalline PV modules and a simulated sorting procedure, Monte Carlo techniques were used to generate a large number of artificial PV arrays. The MMLs for each of these arrays were then calculated to assess the sorting procedure’s ability to reduce MML. Overall MMLs were quite small (0.001–0.01%). Sorting by resulted in the most consistent MML reductions. Sorting by yielded insignificant results. Sorting by yielded significant MML reduction in only one of the two PV module data sets. Analysis was conducted to quantify if additional sorting on top of what both manufacturers had already done would make economic sense. Based on high level economic analysis, it appears that additional sorting yields little economic gain; however, this is highly dependent upon manufacturer sorting cost.
Minimally invasive therapy for epiphrenic diverticula: Systematic review of literature and report of six cases

INTRODUCTION: Epiphrenic diverticula (ED) are infrequent and conventional surgical treatment entails aggressive open or transthoracic surgery. Minimally invasive treatment has changed the surgical approach but some surgical controversies are not resolved. OBJECTIVE: The objective of this study is to describe our experience in minimally invasive treatment of the ED and to perform a systematic review of the current literature in this subject. MATERIALS AND METHODS: We reviewed all data from the Hospital de Sant Pau, focusing on patients that underwent minimally invasive treatment for an ED since 1998 to date. Furthermore, we performed a systematic literature review focused on the minimally invasive approach for ED. RESULTS: A total of 6 patients have been treated (5 transhiatal and 1 with abdominal and thoracic approach). We found a predominance of males with a median age of 63. The diagnosis was made with an endoscopy, barium swallow and manometry. Half of the manometry results were pathologic. The surgical technique involved a diverticulectomy, myotomy and a Dor partial founduplication. Two patients that presented suture line leakage (SLL) were treated conservatively. No mortality was reported. The systematic review was carried out under the Preferred Reporting Items for Systematic Reviews and Meta-analyses scheme, with a total of 20 studies where 189 patients were found. No comparative or prospective randomised trials were found. Overall morbidity was 24%, with a SLL rate of 12%, hospital stay of 5 days and mortality of 1.5%. After a median follow-up of 42 months, 81.5% of the patients were asymptomatic. CONCLUSION: The minimally invasive approach for ED is a safe and feasible procedure.