Miracle-dz/UniFAR-FTUs huggingface dataset:
Recurrent Acute Otitis Media Could Be Related to the Pro-Inflammatory State That Causes an Incorrect Diet

Introduction: Acute Otitis Media (AOM) is the most commonly-occurring bacterial complication in childhood. After making certain corrections to the patients’ dietary habits, which we found to be excessively high in animal-based and industrially-processed foods, we observed a significant reduction in recurrent colds and their bacterial complications. We promote an original way of treating these diseases, since until now the conventional treatment is based on pharmacological and surgical treatment. From our point of view, the mucosa that covers the entire ENT area is in a pro-inflammatory and hyper-reactive state, as a consequence of the alterations produced by an inadequate diet. For us there is no difference in the nutritional treatment of the different mucous membranes that cover the ENT area. The purpose of the study was to assess the effects of the Traditional Mediterranean Diet (TMD) on patients diagnosed with Recurring Acute Otitis Media (RAOM). Methods: prospective pre-postest comparison study with 48 girls and 42 boys aged 1–5 years, each of whom had been and included on the 1-year programme “Learning to eat the Mediterranean Way”, designed to encourage the adoption of the TMD. We studied clinical and therapeutic variables and various anthropometric parameters. Results: all the symptomatic indicators studied (number and intensity of episodes of otitis and emergency admissions) showed a positive and statistically significant evolution in RAOM. By the end of the study, none of the patients met the criteria for classification as RAOM, and 60% percent of patients did not present any further episodes of AOM. In line with the above, the use of anti-microbial drugs and symptomatic treatments reduced considerably; the use of antibiotics dropped from 4.30 occasions/patient/year, to 0.66 (p < 0.001), and the used of symptomatic treatments dropped from 7.63 to 2.75 (p < 0.001). The level of family satisfaction was very high. Conclusions: the adoption of the Traditional Mediterranean Diet has been demonstrated to significantly reduce occurrence of acute otitis media and may contribute to the treatment of patients diagnosed with recurrent acute otitis media.
Papillary and Trabecular Muscles Have Substantial Impact on Quantification of Left Ventricle in Patients with Hypertrophic Obstructive Cardiomyopathy

Patients with obstructive hypertrophic cardiomyopathy (HOCM) have large papillary and trabecular muscles (PTMs), which are myocardial tissue. PTMs are usually excluded from the myocardium and included in the left ventricular (LV) cavity when determining LV mass (LVM) and volumes using cardiac magnetic resonance (CMR). This conventional method may result in large distortion of LVM and other indices. We investigated 74 patients with HOCM undergoing CMR imaging. LV short-axis cine images were obtained. LV contours were drawn using two different methods: (1) the conventional method, where PTMs were included in the LV cavity; and (2) the mask method, which includes the TPMs in the LV myocardium. The LV end-diastolic volume (LV-EDV), LV end-systolic volume (LV-ESV), LV ejection fraction (LVEF), and the LVM were then calculated. Fasting NT-proBNP and CK-MB levels were measured with ELISA. In patients with HOCM, mass of PTMs (MOPTM) was 47.9 ± 18.7 g, which represented 26.9% of total LVM. Inclusion of PTMs with the mask method resulted in significantly greater LVM and LVM index (both p < 0.0001) in comparison with those measured with the conventional method. In addition, the mask method produced a significant decrease in LV-EDV and LV-ESV. LVEF was significantly increased with the mask method (64.3 ± 7.9% vs. 77.2 ± 7.1%, p < 0.0001). MOPTM was positively correlated with BMI, septal wall thickness, LVM, LV-EDV, and LV-ESV. LVEF was inversely correlated with MOPTM. In addition, MOPTM correlated positively with NT-proBNP (r = 0.265, p = 0.039) and CK-MB (r = 0.356, p = 0.002). In conclusion, inclusion of PTMs in the myocardium has a substantial impact on quantification of the LVM, LV-EDV, LV-ESV, and LVEF in patients with HOCM. The effects of the PTMs in women was greater than that in men. Furthermore, the MOPTM was positively associated with NT-proBNP and CK-MB. The PTMs might be included in the myocardium when measuring the LV volumes and mass of patients with HOCM. At present, the clinical and prognostic meaning and relevance of the PTMs is not clear and should be further studied.
A Novel Two-Phase Mode Switching Control Strategy for PMSM Position Servo Systems With Fast-Response and High-Precision

In this article, a novel mode switching control (MSC) strategy is proposed containing a fast-response phase and a high-precision settling phase to meet the requirement of high-quality point-to-point permanent magnet synchronous motor servo systems. In the fast-response stage, an adaptive trajectory planning method is developed to program the q-axis current profile online based on the reference for the motor to reach the neighborhood of the reference position in minimum time. The chattering in the conventional time-optimal control is overcome and the idea that skipping speed and position loop with preplanned q-axis current trajectory is first attempted. After switching, the high-precision settling stage that is responsible for improving the transient performance in terms of reducing the overshoot and settling time is built with the proposed robust composite nonlinear feedback (RCNF) control law. This RCNF method cancels the overall disturbance through an extended state observer. The switching condition for the proposed MSC controller is clarified. Afterward, the whole closed-loop system's stability is strictly proved. Experiments are then conducted based on different scenarios to prove the effectiveness and robustness of the proposed MSC method.
Analysis of the sales representatives' profile in DellEMC Rio de Janeiro through the Challenger Sale model

Sales panorama has been changing through the years and even more since the 2008 global crisis. Since then, companies started to demand more from the suppliers and their sales representatives; especially in more the complex sectors like Information Technologies (IT). Companies have been adapting their sales strategies to increase sales; however few have studied the sales representatives’ behavior with the client. Based on the Challenger Sale model this project aims to study the sales representatives’ profile in an IT market leader – DellEMC, Rio de Janeiro. The project was developed as a unique case study due to the leadership characteristics’ of DellEMC, A questionnaire was developed and administered to DellEMC’s sales department. According to the Challenger Sale model, DellEMC’s sales representatives appeared to have characteristics from all the three model dimensions – Teaching for differentiation; Tailoring for resonance and Taking Control of the sale. However it was also recognized that some factors like organizational culture or market characteristics contribute on the sales representatives’ behavior. This project has no intension on generalization but to refine the Challenger Sale model theory and applicability to the specific case of DellEMC.
Early life adversity, reproductive history and breast cancer risk

Abstract Background and objectives Individuals who experience early life adversity are at an increased risk for chronic disease later in life. Less is known about how early life factors are associated with cancer susceptibility. Here, we use a life history framework to test whether early life adversity increases the risk of breast cancer. We predict that early life adversity can shift investment in somatic maintenance and accelerate the timing of reproduction, which may mediate or interact with the risk of breast cancer. Methodology We use population-wide data from the Utah Population Database (UPDB) and Utah Cancer Registry, leading to 24 957 cases of women diagnosed with breast cancer spanning 20 years (1990–2010) and 124 785 age-matched controls. We generated a cumulative early life adversity summation score to evaluate the interaction (moderation) and mediation between early life adversity, reproductive history and their association with breast cancer risk. Results Our analyses led to three key findings: (i) more early life adversity, when considered as a main effect, accelerates the time to first birth and death, (ii) early age at first birth and high parity decreases the risk of breast cancer and (iii) we find no association between early adversity and breast cancer risk either as a main effect or in its interaction with reproductive history. Conclusion and implications Early adversity elevates the risk of overall mortality through mechanisms other than breast cancer risk. This suggests early life factors can generate different effects on health. Future work should incorporate more complex view of life history patterns, including multiple life stages, when making predictions about cancer susceptibility.
Towards the Phenomenology of Hybrids as Regenerative Design and use – a Post-Heideggerian Account

Grasping the identity of hybrids, that is beings which cross the binarism of nature and technology (e.g. genetically-modified organisms (GMOs), synbio inventions, biomimetic projects), is problematic since it is still guided by self-evident dualistic categories, either as artefacts or as natural entities. To move beyond the limitations of such a one-sided understanding of hybrids, we suggest turning towards the categories of affordances and the juxtaposition of needs and patterns of proper use, as inspired by the Heideggerian version of phenomenology. Drawing upon selected concepts by Heidegger, we argue that hybrids can be conceptualised as a regenerative design and use to serve the planet. We argue that the ideal type of non-exploitative account of hybrids consists of the adaptive approach to the environment, which does not, however, exclude the possibility of designing and constructing new beings. We also point out that hybrids undermine the divide of being destructive/regenerative which marks the boundaries of nature and technology.
Assessing reservoir effect on water quality in the Missouri River basin using the soil and water assessment tool (SWAT) model

The flow regimes of the Missouri River Basin (MORB) have been significantly altered by hundreds of large and small reservoirs distributed throughout the basin. However, the impacts of these reservoirs on water quality dynamics have not been systemically studied. Therefore, we applied the Soil and Water Assessment Tool (SWAT) to evaluate how these reservoirs would affect sediment and nutrient loads in the MORB. Calibration and validation of the model indicated that the simulated streamflow and water quality at each gauge site across the MORB was in agreement with observation. Results showed that sediment and nutrient export in the MORB would be significantly reduced by the reservoirs. The mean annual total suspended sediment (TSS), total nitrogen (TN), and total phosphorous (TP) loads at the outlet of MORB were reduced by 11.9%, 7.6%, and 14.6%, respectively between 1997 and 2016. In addition, many small reservoirs could have an equivalent reduction effect on sediment and nutrient loads at the outlet as a large one due to similar trapping effects of these reservoirs and the weakening effect along the channel. Moreover, reservoirs near the mouth of the river reduced more TSS than those located in the upper watershed. But they made slightly less TN and TP reductions than those upstream ones because of not at the source area of the nutrients. These results suggested that reservoirs had substantial effects on water quality in the MORB, and the effects varied with the reservoirs' size and location.
Collectively constructing gender-inclusive work cultures in STEM

ABSTRACT We review a program of work articulating the concept of inclusion – and approaches for achieving it – for women working in Science, Technology, Engineering, and Maths (STEM) organisations. A multi-level framework is described to characterise inclusion in STEM workplaces. This framework is then used to conceptualise a series of empirical studies exploring women’s experiences of STEM work cultures. Together, these studies show that identity-based inclusion is the product of institutional policies and practices, interpersonal dynamics, and individuals’ beliefs and biases. We then use our multi-level framework to discuss practical insights for creating inclusive cultures in STEM organisations. We offer a series of empirically informed actionable suggestions for spreading and establishing inclusive norms in STEM organisations. Our framework suggests that creating contexts where employees can effectively learn inclusive norms will help organisations construct gender-inclusive work cultures in STEM.
Parent-Reported Barriers and Enablers to Establishing Sun Safety Practices with Young Children in Australia

ABSTRACT This study investigated parent-reported barriers and enablers to establishing sun safety practices with young children (0–4 years; N = 423) living in Australia. An online survey examined parent/child adherence to recommended sun safety practices and barriers and enablers to establishing sun safety practices. Adherence to different sun safety practices varied across age groups. Lack of child cooperation was the most commonly-endorsed barrier while child compliance was the most commonly-endorsed facilitator. Young children’s lack of cooperation with sun safety practices represents a major obstacle for parents. In conclusion, the development and testing of family-based intervention approaches to reduce child resistance and promote cooperation is warranted.
Flow aeration and surface fluctuations in moderate-slope stepped chute: from aeration inception to fully developed aerated flow

ABSTRACT Although stepped chute flows have been studied for a variety of chute geometries and flow conditions, reports on air–water flow development in the fully developed aerated region are not as comprehensive as those in the nonaerated and developing aerated regions. In this paper, skimming air–water flows in a large stepped chute (1V:2.5H) were studied comparatively for two step heights, showing different stages for velocity and aeration development downstream the inception point. The mean air concentration reached a constant level while the bubble frequency kept increasing slowly in the fully developed region. The developed mean air concentration was related to the sloping angle, step height and flow discharge. The results provided possible prediction of maximum bubble frequency and its longitudinal evolution, and a glance at the scale effect on it. The free-surface fluctuations and splash height were presented, with particular attention to the effects of step height on the turbulence and aeration modification.
Applying Different Resampling Strategies In Random Forest Algorithm To Predict Lumpy Skin Disease

The spread of Lumpy Skin Disease (LSD) that infects livestock is increasingly widespread in various parts of the world. Early detection of the disease’s spread is necessary so that the economic losses caused by LSD are not higher. The use of machine learning algorithms to predict the presence of a disease has been carried out, including in the field of animal health. The study aims to predict the presence of LSD in an area by utilizing the LSD dataset obtained from Mendeley Data. The number of lumpy infected cases is so low that it creates imbalanced data, posing a challenge in training machine learning models. Handling the unbalanced data is performed by sampling technique using the Random Under-sampling technique and Synthetic Minority Oversampling Technique (SMOTE). The Random Forest classification model was trained on sample data to predict cases of lumpy infection. The Random Forest classifier performs very well on both under-sampling and oversampling data. Measurement of performance metrics shows that SMOTE has a superior score of 1-2% compared to the use of Random Undersampling. Furthermore, Re-call rate, which is the metric we want to maximize in identifying lumpy cases, is superior when using SMOTE and has slightly better precision than Random Undersampling. This research only focuses on how to balance unbalanced data classes so that the optimization of the model has not been implemented, which creates opportunities for further research in the future.
Selenoprotein: Potential Player in Redox Regulation in Chlamydomonas reinhardtii

Selenium (Se) is an essential micro-element for many organisms, including Chlamydomonas reinhardtii, and is required in trace amounts. It is obtained from the 21st amino acid selenocysteine (Sec, U), genetically encoded by the UGA codon. Proteins containing Sec are known as selenoproteins. In eukaryotes, selenoproteins are present in animals and algae, whereas fungi and higher plants lack them. The human genome contains 25 selenoproteins, most of which are involved in antioxidant defense activity, redox regulation, and redox signaling. In algae, 42 selenoprotein families were identified using various bioinformatics approaches, out of which C. reinhardtii is known to have 10 selenoprotein genes. However, the role of selenoproteins in Chlamydomonas is yet to be reported. Chlamydomonas selenoproteins contain conserved domains such as CVNVGC and GCUG, in the case of thioredoxin reductase, and CXXU in other selenoproteins. Interestingly, Sec amino acid residue is present in a catalytically active domain in Chlamydomonas selenoproteins, similar to human selenoproteins. Based on catalytical active sites and conserved domains present in Chlamydomonas selenoproteins, we suggest that Chlamydomonas selenoproteins could have a role in redox regulation and defense by acting as antioxidants in various physiological conditions.
Low-Cost Wide-Angle Beam-Scanning Transmitarray Antennas Using Lens-Loaded Patch Elements: A Proof-of-Concept Study

In this letter, a novel design concept to achieve a low-cost wide-angle beam-scanning transmitarray (TA) using lens-loaded patch (LLP) elements is presented. In this design, each TA element consists of a beam switchable transmitting element, a group of receiving elements, and a signal via. The received powers of a 2×2 subarray are first combined and then transmitted to the corresponding LLP element, where the phases of the transmitted signals are manipulated for beamforming. Compared with the conventional designs, the phase shifters (PSs) can be multiplexed and the number of PSs is effectively eliminated by 75%, which significantly decreases the hardware cost. By employing multiple patches as the feed of the lenses, reconfigurable radiation patterns are obtained, and by properly choosing the transmitting patches, the developed TA achieves a wide-angle two-dimensional beam scanning within ±60° with stable gains. To validate the design concept, passive prototypes with a center frequency of 12.5 GHz are simulated, fabricated, and tested. The measured results show that the aperture efficiency is 30.1%, 19.4%, and 14.1% for beams steered to 0°, 30°, and 60° at 12.5 GHz, respectively. The beam coverage of ±60° with a less than 3.5 dB scanning loss in the H-plane is obtained.
Bir Boyutlu Dinamik Analiz ve Mikrotremor Ölçüm Sonuçlarının Karşılaştırılması

Depremler sirasinda zemin tabakalarinda olusan deformasyon seviyeleri, yapi-zemin etkilesiminde onemli rol oynamaktadir. Kuvvetli yer hareketi kayitlari kullanilarak yapilan bir boyutlu (1D) dinamik analizlerle yuzeye yakin zemin tabakalari icin hesaplanan kayma sekil degistirmeleri, kucuk genlikli titresimler-mikrotremor verisi analiz sonuclarinin tasarim yer hareketine ait en buyuk yatay ivme degeriyle birlikte degerlendirilmesiyle de tahmin edilebilmektedir. Bu calismada, Kuzey Anadolu Fay Hattina yakin bir bolgede zemin tabakalarinin deprem hareketi karsisindaki davranisi hem 14 farkli ana kaya ivme kaydi kullanilarak yapilan 1D esdeger lineer dinamik analizlerle hem de mikrotremor olcumlerinin analizi yardimiyla elde edilmistir. Verilerin degerlendirilmesi sonucunda; kuvvetli yer hareketi sirasinda yuzeye yakin zemin tabakalarinda olusacak kayma birim sekil degistirmesinin belirlenebilmesi amaciyla, elastik ve elasto-plastik deformasyon seviyelerini kapsayan bir baginti onerilmistir.
Higher order generalization of Fukaya's Morse homotopy invariant of 3-manifolds I. Invariants of homology 3-spheres

We give a generalization of Fukaya's Morse homotopy theoretic approach for 2-loop Chern--Simons perturbation theory to 3-valent graphs with arbitrary number of loops at least 2. We construct a sequence of invariants of integral homology 3-spheres with values in a space of 3-valent graphs (Jacobi diagrams or Feynman diagrams) by counting graphs in an integral homology 3-sphere satisfying certain condition described by a set of ordinary differential equations.
Metric learning‐based whole health indicator model for industrial robots

Aiming at the problems of complex structure, high components coupling, and difficultly monitoring of the whole health status with the industrial robot, a metric learning‐based whole health indicator model is proposed. First, according to the more obvious degradation characteristics of industrial robots during accelerated operation, the accelerated signal is segmented and then the time‐domain features are extracted. Second, the long‐term and short‐term memory (LSTM) network combined with the multihead attention is used to construct the network model, and the metric learning method is adopted to learn the similarity measurement method of the industrial robot monitoring data. Finally, the similarity measure method got from metric learning is used to construct the whole health indicator, which describes the whole degradation trend of the industrial robot. The experiments are based on the real accelerated aging data set from industrial robots. The results show that the proposed model can effectively construct the whole health indicator for industrial robots. The average trend of the proposed model reaches 0.9769. The average monotonicity reaches 0.5666, which is 0.1748, 0.1577, and 0.1492 higher than the similarity measurement method based on Euclidean distance, Markov distance, and LSTM.
Diversification and shared features of tumor‐binding antibody repertoires in tumor, sentinel lymph node and blood of three patients with breast cancer

B cell‐mediated immunity can be associated with favorable clinical outcomes in cancer patients. However, the mechanism and features of anti‐tumor immune responses are not well understood. In particular, how B cells expressing tumor‐specific antibodies are distributed (in the tumor vs. the circulation) has not been well defined.