Miracle-dz/UniFAR-FTUs huggingface dataset:
Tauroursodeoxycholate—Bile Acid with Chaperoning Activity: Molecular and Cellular Effects and Therapeutic Perspectives

Tauroursodeoxycholic acid (TUDCA) is a naturally occurring hydrophilic bile acid that has been used for centuries in Chinese medicine. Chemically, TUDCA is a taurine conjugate of ursodeoxycholic acid (UDCA), which in contemporary pharmacology is approved by Food and Drug Administration (FDA) for treatment of primary biliary cholangitis. Interestingly, numerous recent studies demonstrate that mechanisms of TUDCA functioning extend beyond hepatobiliary disorders. Thus, TUDCA has been demonstrated to display potential therapeutic benefits in various models of many diseases such as diabetes, obesity, and neurodegenerative diseases, mostly due to its cytoprotective effect. The mechanisms underlying this cytoprotective activity have been mainly attributed to alleviation of endoplasmic reticulum (ER) stress and stabilization of the unfolded protein response (UPR), which contributed to naming TUDCA as a chemical chaperone. Apart from that, TUDCA has also been found to reduce oxidative stress, suppress apoptosis, and decrease inflammation in many in-vitro and in-vivo models of various diseases. The latest research suggests that TUDCA can also play a role as an epigenetic modulator and act as therapeutic agent in certain types of cancer. Nevertheless, despite the massive amount of evidence demonstrating positive effects of TUDCA in pre-clinical studies, there are certain limitations restraining its wide use in patients. Here, molecular and cellular modes of action of TUDCA are described and therapeutic opportunities and limitations of this bile acid are discussed.
HPV circulating tumoral DNA quantification by droplet‐based digital PCR: A promising predictive and prognostic biomarker for HPV‐associated oropharyngeal cancers

We aimed to determine whether pretherapeutic assessment of HPV circulating tumoral DNA (HPV ctDNA) by droplet‐based digital PCR (ddPCR) could constitute a predictive and prognostic biomarker for HPV‐associated oropharyngeal squamous cell carcinoma (OPSCC). A mono‐institutional prospective biomarker study on 66 patients with p16+/HPV16‐positive oropharyngeal squamous cell carcinoma (OPSCC) was conducted in European Georges Pompidou Hospital, Paris, France. Blood samples were collected at the time of diagnosis before any treatment. Optimized digital PCR assays were used to quantify HPV16 ctDNA. Forty‐seven (71%) patients showed a positive pretherapeutic HPV ctDNA at time of diagnosis. Interestingly, the quantity of HPV16 ctDNA at baseline, as assessed by ddPCR, was significantly correlated with the T/N/M status or OPSCC stages according to the 2018 new staging criteria for high‐risk human papillomavirus (HR HPV) related OPSCC from American Joint Committee on Cancer (AJCC). Moreover, all recurrences and the majority (83%) of death reported events occurred in patients with positive HPV16 ctDNA at baseline. Finally, when posttreatment blood samples were available (n = 6), the kinetic of pretreatment/posttreatment HPV16 ctDNA was clearly associated with treatment success or failure. HPV ctDNA monitoring by ddPCR could constitute a useful and noninvasive dynamic biomarker to select HR HPV‐related OPSCC patients eligible for potential treatment de‐escalation and to monitor treatment response.
Effect of Labor Epidural Analgesia With Hydromorphone on Neonatal Neurobehavior and Breastfeeding Behavior in the First 24 Hours of Life

Epidural opioids and local anesthetics may depress the neonatal reflexes necessary for breastfeeding success. Literature review yielded no data for hydromorphone and conflicting results for fentanyl. This study investigated whether breastfeeding effectiveness would be less in infants whose mothers received epidural analgesia with hydromorphone compared with those whose mothers received no analgesia, and whether the total amount of drugs given or the presence of multiple stressful events or interventions would be related to the effectiveness of breastfeeding. Breastfeeding behaviors were studied in 51 infants whose mothers chose epidural analgesia compared with 51 infants whose mothers chose to have no analgesia. Women with epidural analgesia received 1.5% lidocaine with 1:200,000 epinephrine as a test dose and/or 0.25% bupivacaine with 1:200,000 epinephrine as a bolus, and 100 μg hydromorphone followed by continuous infusion of 0.05% bupivacaine with 3 μg/mL hydromorphone at 14 mL/hour. The hospital setting strongly supported breastfeeding. Effectiveness of breastfeeding was measured with the LATCH Breastfeeding Assessment Tool at 3, 12, and 24 hours after birth. Cynthia Ann French – University of Connecticut, 2015 LATCH scores did not differ significantly between groups at any time point and were not related to total amount of drugs administered. The presence of multiple stressful events and interventions, e.g., long duration of labor, large amount of IV fluids, oxytocin administration, induction of labor, and meconium staining/suctioning of the baby, did not significantly affect breastfeeding behavior in the overall study population (n=102), altogether contributing not more than 8% of the variability of LATCH scores in the regression model. The group receiving epidural analgesia (n=51) had significantly longer duration of labor, higher rates of oxytocin administration and induction of labor, and larger amounts of IV fluid administration. These factors contributed approximately 30% of the variability of LATCH scores at 3 and 24 hours. However, this finding was not significant. Although the study was limited by its nonrandomized nature, these data indicate that, by itself, epidural analgesia with hydromorphone does not decrease effectiveness of breastfeeding behaviors. Epidural analgesia increases risk of multiple stressful events or interventions, which may contribute to breastfeeding difficulties and necessitate intensive help from the nurse to achieve success in breastfeeding.
Oxygen delivery, oxygen consumption and decreased kidney function after cardiopulmonary bypass

Introduction Low oxygen delivery during cardiopulmonary bypass is related to a range of adverse outcomes. Previous research specified certain critical oxygen delivery levels associated with acute kidney injury. However, a single universal critical oxygen delivery value is not sensible, as oxygen consumption has to be considered when determining critical delivery values. This study examined the associations between oxygen delivery and oxygen consumption and between oxygen delivery and kidney function in patients undergoing cardiopulmonary bypass. Methods Oxygen delivery, oxygen consumption and kidney function decrease were retrospectively studied in 65 adult patients. Results Mean oxygen consumption was 56 ± 8 ml/min/m2, mean oxygen delivery was 281 ± 39 ml/min/m2. Twenty-seven patients (42%) had an oxygen delivery lower than the previously mentioned critical value of 272 ml/min/m2. None of the patients developed acute kidney injury according to RIFLE criteria. However, in 10 patients (15%) a decrease in the estimated glomerular filtration rate of more than 10% was noted, which was not associated with oxygen delivery lower than 272 ml/min/m2. Eighteen patients had a strong correlation (r >0.500) between DO2 and VO2, but this was not related to low oxygen delivery. Central venous oxygen saturation (77 ± 3%), oxygen extraction ratio (21 ± 3%) and blood lactate levels at the end of surgery (1.2 ± 0.3 mmol/l) showed not to be indicative of insufficient oxygen delivery either. Conclusions This study could not confirm an evident correlation between O2 delivery and O2 consumption or kidney function decrease, even at values below previously specified critical levels. The variability in O2 consumption however, is an indication that every patient has individual O2 needs, advocating for an individualized O2 delivery goal.
EXPECTATIVAS DE FAMILIARES SOBRE UMA UNIDADE DE INTERNAÇÃO PSIQUIÁTRICA

Objetivou-se compreender as expectativas de familiares sobre uma unidade de internacao psiquiatrica na perspectiva da sociologia fenomenologica de Alfred Schutz. Trata-se de uma pesquisa qualitativa, de natureza fenomenologica, com 15 familiares de pacientes de uma unidade de internacao psiquiatrica de um hospital universitario no sul do pais. A coleta de informacoes deu-se entre agosto e setembro de 2013, por meio de entrevista fenomenologica, e a analise foi desenvolvida a luz da sociologia fenomenologica. Os resultados apontam que as expectativas de familiares estao atreladas a interpretacao e as vivencias que estes tem do mundo da vida cotidiana; elas devem ser valorizadas no cuidado ao paciente e a familia; e podem integrar a familia ao cuidado do paciente. Espera-se contribuir para que profissionais e gestores reflitam sobre a importância de compreender-se as expectativas dos familiares sobre a unidade, visando a implementacao de acoes em saude mais efetivas, pautadas nas relacoes sociais entre os sujeitos.
An international comparison of deceased donor kidney utilization: What can the United States and the United Kingdom learn from each other?

In transplant, meaningful international comparisons in organ utilization are needed. This collaborative study between the United Kingdom (UK) and the United States (US) aimed to develop a kidney utilization metric allowing for legitimate intercountry comparisons. Data from the UK and US transplant registries, including all deceased donor kidneys recovered from 2006 to 2017, were analyzed. To identify a potentially comparable kidney utilization rate (UR), several denominators were assessed. We discovered that the proportion of transplanted kidneys from elderly donors in the UK (10.7%) was 18 times greater than that in the US (0.6%). Conversely, en bloc pediatric kidney transplant was more common in the US. Donation after circulatory death utilization has risen in both countries but is twice as prevalent in the UK (39% of transplants) vs the US (20%). In addition, US and UK URs are not directly comparable due to fundamental system differences. However, using a suite of URs revealed practice areas likely to yield the most benefit if improved, such as efforts to increase kidney offer acceptance in the US and to reduce postacceptance discard in the UK. Methods used in this study, including novel intracountry risk‐adjusted UR trend logistic regression analyses, can be translated to other international transplant registries in pursuit of further global learning opportunities.
Potential health effects of low dose radiation and what it means to the practice of radiation protection

If we ask a group of intelligent and educated individuals not familiar with the science or practice of radiation protection to review published information on health effects of exposures to low levels of radiation and share their findings, they are likely to come away with an understanding that is as clear as mud. This is unfortunate. While the unfamiliar jargon, complex quantities and concepts, linguistic nuances, and inherent uncertainties provide a fertile ground for confusion, there is another contributing factor to this bewilderment, with potentially damaging long-term consequences: it is not unusual to find instances in scientific publications or conferences where the system of radiation protection or its scientific underpinnings are misrepresented or mischaracterised. The language used by some authors target the credibility and intentions of respected institutions and independent radiation protection commissions that for nearly a century have laid the foundation of radiation protection practice and are the regarded authoritative voices in this field. Eroding trust in those institutions, not only among young professionals entering the field but the public in general, can have devastating consequences. To ‘immunise’ against such misinformation and misleading characterisations, objective overviews of the current state of science and demonstrations of how that science is used to inform radiation protection policy and decision making can equip radiation protection professionals with the information they need. Recognising this need, the American Academy of Health Physics (AAHP) sponsored a full-day technical session on 17 July 2018 at the annual meeting of the Health Physics Society (HPS) in Cleveland, Ohio. This session was structured to describe the current state of science, from molecular biology to human epidemiology, as well as to explain how that science is translated to radiation protection policy and regulations for low levels of radiation. In addition, the expected role of radiation protection professionals was discussed at length. The feedback from conference attendees was positive and encouraging, indicating that the information presented filled a need. To make this material available to the broader community, the Journal of Radiological Protection invited speakers of the AAHP session to submit manuscripts based on their presentations for peer review and inclusion in this special issue.
A Case Study of Adding Proactivity in Indoor Social Robots Using Belief–Desire–Intention (BDI) Model

The rise of robots and robotics has proved to be a benefaction to humankind in different aspects. Robotics evolved from a simple button, has seen massive development over the years. Consequently, it has become an integral part of human life as robots are used for a wide range of applications ranging from indoor uses to interplanetary missions. Recently, the use of social robots, in commercial indoor spaces to offer help or social interaction with people, has been quite popular. As such, taking the increasing use of social robots into consideration, many works have been carried out to develop the robots to make them capable of acting like humans. The notion behind this development is the need for robots to offer services without being asked. Social robots should think more like humans and suggest possible and suitable actions by analyzing the environment where they are. Belief–desire–intention (BDI) is one of the most popular models for developing rational agents based on how humans act based on the information derived from an environment. As such, this work defines a foundation architecture to integrate a BDI framework into a social robot to add “act like a human” feature for proactive behaviors. The work validates the proposed architecture by developing a vision-based proactive action using the PROFETA BDI framework in an indoor social robot, Waldo, operated by the robot operating system (ROS).
Heartburn-Related Internet Searches and Trends of Interest across Six Western Countries: A Four-Year Retrospective Analysis Using Google Ads Keyword Planner

The internet is becoming the main source of health-related information. We aimed to investigate data regarding heartburn-related searches made by Google users from Australia, Canada, Germany, Poland, the United Kingdom, and the United States. We retrospectively analyzed data from Google Ads Keywords Planner. We extracted search volumes of keywords associated with “heartburn” for June 2015 to May 2019. The data were generated in the respective primary language. The number of searches per 1000 Google-user years was as follows: 177.4 (Australia), 178.1 (Canada), 123.8 (Germany), 199.7 (Poland), 152.5 (United Kingdom), and 194.5 (United States). The users were particularly interested in treatment (19.0 to 41.3%), diet (4.8 to 10.7%), symptoms (2.6 to 13.1%), and causes (3.7 to 10.0%). In all countries except Germany, the number of heartburn-related queries significantly increased over the analyzed period. For Canada, Germany, Poland, and the United Kingdom, query numbers were significantly lowest in summer; there was no significant seasonal trend for Australia and the United States. The number of heartburn-related queries has increased over the past four years, and a seasonal pattern may exist in certain regions. The trends in heartburn-related searches may reflect the scale of the complaint, and should be verified through future epidemiological studies.
Call for Participation: Collaborative Benchmarking of Functional-Structural Root Architecture Models. The Case of Root Water Uptake

Three-dimensional models of root growth, architecture and function are becoming important tools that aid the design of agricultural management schemes and the selection of beneficial root traits. However, while benchmarking is common in many disciplines that use numerical models such as natural and engineering sciences, functional-structural root architecture models have never been systematically compared. The following reasons might induce disagreement between the simulation results of different models: different representation of root growth, sink term of root water and solute uptake and representation of the rhizosphere. Presently, the extent of discrepancies is unknown, and a framework for quantitatively comparing functional-structural root architecture models is required. We propose, in a first step, to define benchmarking scenarios that test individual components of complex models: root architecture, water flow in soil and water flow in roots. While the latter two will focus mainly on comparing numerical aspects, the root architectural models have to be compared at a conceptual level as they generally differ in process representation. Therefore defining common inputs that allow recreating reference root systems in all models will be a key challenge. In a second step, benchmarking scenarios for the coupled problems are defined. We expect that the results of step 1 will enable us to better interpret differences found in step 2. This benchmarking will result in a better understanding of the different models and contribute towards improving them. Improved models will allow us to simulate various scenarios with greater confidence and avoid bugs, numerical errors or conceptual misunderstandings. This work will set a standard for future model development.
Vortex Beam Encoded All-Optical Logic Gates Based on Nano-Ring Plasmonic Antennas

Vortex beam encoded all-optical logic gates are suggested to be very important in future information processing. However, within current logic devices, only a few are encoded by using vortex beams and, in these devices, some space optical elements with big footprints (mirror, dove prism and pentaprism) are indispensable components, which is not conducive to device integration. In this paper, an integrated vortex beam encoded all-optical logic gate based on a nano-ring plasmonic antenna is proposed. In our scheme, by defining the two circular polarization states of the input vortex beams as the input logic states and the normalized intensity of the plasmonic field at the center of the nano-ring as the output logic states, OR and AND (NOR and NAND) logic gates are realized when two 1st (1st) order vortex beams are chosen as the two input signals; and a NOT logic gate is obtained when one 1st order vortex beam is chosen as the input signal. In addition, by defining the two linear polarization states (x and y polarization) of the input vortex beams as the two input logic states, an XNOR logic gate is realized when two 1st order vortex beams are chosen as the two input signals.
GBX2, as a tumor promoter in lung adenocarcinoma, enhances cells viability, invasion and migration by regulating the AKT/ERK signaling pathway

Increasing evidence shows that gastrulation brain homeobox 2 (GBX2) is involved in multiple cancers. However, whether GBX2 has an effect on the lung adenocarcinoma remains unclear. In the present study, we investigated the functions of GBX2 on lung adenocarcinoma and explored the underlying mechanism.
Formation of Indomethacin-Saccharin Cocrystals during Wet Granulation: Role of Polymeric Excipients.

Formulation of a cocrystal into a solid pharmaceutical dosage form entails numerous processing steps during which there is risk of dissociation. In an effort to reduce the number of unit operations, we have attempted the in situ formation of indomethacin-saccharin (INDSAC) cocrystal during high-shear wet granulation (HSWG). Wet granulationHSWG of IND (poorly water-soluble drug) and SAC (coformer), with polymers (granulating agents), was carried out using ethanol as the granulation liquid and yielded INDSAC cocrystal granules. Therefore, cocrystal formation and granulation were simultaneously accomplished. Our objectives were to, (i) evaluate the influence of polymers on cocrystal formation kinetics during wet granulation, and (ii) mechanistically understand the role of polymers in facilitating cocrystal formation. Polyvinylpyrrolidone (PVP), hydroxypropyl cellulose (HPC), and polyethylene oxide (PEO) were chosen to investigate the influence of soluble polymers. The cocrystal formation kinetics was influenced by polymer (PVP < HPC < PEO) and its concentration. The interaction of polymer with cocrystal components inhibited cocrystal formation. Complete cocrystal formation was observed in presence of PEO, a polymer which does not interact with IND and SAC.
DNA damage responses in murine Pre-B cells with genetic deficiencies in damage response genes

ABSTRACT DNA damage can be generated in multiple ways from genotoxic and physiologic sources. Genotoxic damage is known to disrupt cellular functions and is lethal if not repaired properly. We compare the transcriptional programs activated in response to genotoxic DNA damage induced by ionizing radiation (IR) in abl pre-B cells from mice deficient in DNA damage response (DDR) genes Atm, Mre11, Mdc1, H2ax, 53bp1, and DNA-PKcs. We identified a core IR-specific transcriptional response that occurs in abl pre-B cells from WT mice and compared the response of the other genotypes to the WT response. We also identified genotype specific responses and compared those to each other. The WT response includes many processes involved in lymphocyte development and immune response, as well as responses associated with the molecular mechanisms of cancer, such as TP53 signaling. As expected, there is a range of similarity in transcriptional profiles in comparison to WT cells, with Atm-/- cells being the most different from the core WT DDR and Mre11 hypomorph (Mre11A/A ) cells also very dissimilar to WT and other genotypes. For example, NF-kB-related signaling and CD40 signaling are deficient in both Atm-/- and Mre11A/A cells, but present in all other genotypes. In contrast, IR-induced TP53 signaling is seen in the Mre11A/A cells, while these responses are not seen in the Atm-/- cells. By examining the similarities and differences in the signaling pathways in response to IR when specific genes are absent, our results further illustrate the contribution of each gene to the DDR. The microarray gene expression data discussed in this paper have been deposited in NCBI’s Gene Expression Omnibus (GEO) (http://www.ncbi.nlm.nih.gov/geo/) and are accessible under accession number GSE116388.