Miracle-dz/UniFAR-FTUs huggingface dataset:
The improved survival rate and cost-effectiveness of a 7-day continuous subcutaneous insulin infusion set

Abstract Aims The purpose of this article is to compare the insulin cost-savings of the Medtronic Extended Infusion Set (or EIS, a.k.a. Extended Wear Infusion Set) designed and labeled for up to 7-day use with rapid-acting insulins to the current standard of care, 2- to 3-day infusion sets. Methods There are three major improvements (reducing insulin waste, plastic waste, and adverse events) with the extended duration of infusion set wear. This analysis focuses on cost savings from reduced insulin wastage during set changes. Studies published on insulin infusion set survival and EIS clinical trial data (NCT04113694) were used to estimate device lifetime performance using a Markov chain Monte Carlo model, including the assessment of adverse effects and device failure. Total costs associated with infusion set change or failure were systematically found in published literature or estimated based on physical usage, and the direct impact on insulin costs was calculated. Results Based on the model and clinical data, EIS users can expect to change their infusion sets about 75 fewer times than standard set users each year. The costs related to unrecoverable insulin during an infusion set and reservoir change in the US were estimated to range from $19.79 to $22.48, resulting in approximately $1324 to $1677 in annual cost-savings for the typical user from minimizing insulin wastage. Limitations The study only assessed devices used within a monitored setting, that is, clinical trials. In addition, the variability associated with healthcare standards and costs and individual treatment variability including insulin dosages, contribute to the uncertainties with the calculations. Conclusions Our analysis demonstrates that by extending the duration of infusion set wear, there may be substantial cost savings by reducing insulin wastage.
A serpin (CvT‐serpin15) of teratocytes contributes to microbial‐resistance in Plutella xylostella during Cotesia vestalis parasitism

Abstract BACKGROUND Parasitic wasps are an important group of entomophagous insects for pest control. As parasitic wasps often lay eggs on or into their associated hosts, parasitoids evolve to utilize several factors including venom, polydnavirus (PDV) to alter host physiology for successful parasitism. Some taxa of endoparasitoids produce teratocytes, which are a type of cell that is released into host insects when wasp eggs hatch. Teratocytes display multifunction in parasitism such as host nutritional exploration, immune and developmental regulation, by secreting plenty of proteins into host hemocoel. RESULTS A serpin (CvT‐serpin15) secreted by teratocytes was characterized. QPCR results showed the expressional level of CvT‐serpin15 was upregulated following bacterial challenges. Enzyme activity experiment indicated the recombinant CvT‐serpin15 protein could interfere with the growth of Gram‐positive bacteria Staphylococcus aureus. The survival rate assay demonstrated CvT‐serpin15 increased survival rate of Plutella xylostella infected by S. aureus. CONCLUSION CvT‐serpin15 secreted by teratocytes would boost the host immune system when pathogens invade host hemocoel during parasitism, and ultimately protect the development of wasp larva from bacterial infection. © 2021 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Prevalence and factors associated with depressive symptoms among family caregivers of palliative care patients at Hospice Africa Uganda

Abstract Caregiving for cancer and HIV/AIDS patients is complex, and the burden may vary with the type of disease, stages of the illness, and the type of palliative care intervention. Cancer and HIV/AIDS diagnosis and treatment adversely affect not only the patients but also their families and caregivers. They are vulnerable to stress, distress, and depression. Studies in developed countries have shown high prevalence of depression among family caregivers, but the scale of the problem among family caregivers in Uganda is not known. Objective This study aimed to establish the prevalence and factors associated with depressive symptoms among family caregivers of palliative care patients at Hospice Africa Uganda. Method We used a mixed method study to determine the prevalence and factors associated with depressive symptoms among family caregivers of palliative care patients at Hospice Africa Uganda. We assessed depressive symptoms using the Patient Health Questionnaire-9 (PHQ-9) and collected socio-demographic data using a tailored questionnaire. We used binary logistic regression to assess for the association between depressive symptomatology and caregiver socio-demographic and clinical characteristics. Results We recruited 161 family caregivers, 64% of whom were female. The study revealed a high prevalence of depressive symptoms (46%) (n = 74) among the family caregivers. Education status and religious affiliation were significantly associated with depressive symptomatology. Significance of results Family caregivers of palliative care patients face a high burden of depressive symptoms. Efforts to care for family caregivers within palliative care should include assessment and management of depressive symptoms in this population.
The Determination of Guanidine Bases in the Blood.∗

Recently, Pfiffner and Myers, 1 in a preliminary report, gave a tentative procedure for the determination of the guanidine bases in blood. In an attempt to apply this method it was found that recoveries of added guanidine in amounts as small as 1 mg. per 100 cc. of blood could not be made. The main difficulty in the determination of these small amounts is the fact that the reagent proposed by Marston 2 does not give a sufficient color production with guanidine in amounts smaller than 0.05 mg. per 5 cc. of solution. It was found that by replacing potassium ferrocyanide with ferricyanide, and eliminating the hydrogen peroxide, a reagent is produced which retains practically all the advantages of Marston's reagent, and in addition gives almost twice as much color with guanidine. The reagent is made by mixing equal volumes of 10 per cent solutions of sodium nitroprusside, potassium ferricyanide, and sodium hydroxide and diluting the mixture with three volumes of water. The color changes from a dark red to a pale yellow in about 20 minutes and is then ready for use. This prepared reagent will usually keep for 12 hours, but if turbidity develops a fresh reagent should be made up. It is used in the proportion of 1 cc. of the reagent to every 5 cc. of the solution to be tested. Equal amounts of guanidine or methyl guanidine give the same color value with the reagent, whereas dimethyl guanidine gives only two-thirds as much color. The color is an orange red, which develops to its maximum in 2 minutes. Creatine gives 1/10 as much color as does guanidine, and the color develops to its maximum in about 5 minutes.
Buffalopox Disease in Livestock and Milkers, India

Buffalopox outbreaks caused by vaccinia virus were observed in villages of Tamil Nadu, India, among lactating buffaloes and cows. Milkers also had lesions on their fingers. Because vaccinia virus is known to have extended its host range in Brazil, we recommend continuous surveillance to understand cross-species transmission and to curtail disease effects.
Condensation of pericentrin proteins in human cells illuminates phase separation in centrosome assembly.

At the onset of mitosis, centrosomes expand the pericentriolar material (PCM) to maximize their microtubule-organizing activity. This step, termed centrosome maturation, ensures proper spindle organization and faithful chromosome segregation. However, as the centrosome expands, how PCM proteins are recruited and held together without membrane enclosure remains elusive. We found that endogenously expressed pericentrin (PCNT), a conserved PCM scaffold protein, condenses into dynamic granules during late G2/early mitosis before incorporating into mitotic centrosomes. Furthermore, the N-terminal portion of PCNT-enriched with conserved coiled-coils (CCs) and low-complexity regions (LCRs)-phase separates into dynamic condensates that selectively recruit PCM proteins and nucleate microtubules in cells. We propose that CCs and LCRs, two prevalent sequence features in the centrosomal proteome, are preserved under evolutionary pressure in part to mediate liquid-liquid phase separation, a process that bestows upon the centrosome distinct properties critical for its assembly and functions.
Rescuing Auditory Temporal Processing with a Novel Augmented Acoustic Environment in an Animal Model of Congenital Hearing Loss

Abstract Congenital sensorineural hearing loss (SNHL) affects thousands of infants each year and results in significant delays in speech and language development. Previous studies have shown that early exposure to a simple augmented acoustic environment (AAE) can limit the effects of progressive SNHL on hearing sensitivity. However, SNHL is also accompanied by hearing loss that is not assessed on standard audiological examinations, such as reduced temporal processing acuity. To assess whether sound therapy may improve these deficits, a mouse model of congenital SNHL was exposed to simple or temporally complex AAE. The DBA/2J mouse strain develops rapid, base to apex, progressive SNHL beginning at birth and is functionally deaf by six months of age. Hearing sensitivity and auditory brainstem function was measured using otoacoustic emissions, auditory brainstem response (ABR) and extracellular recording from the inferior colliculus (IC) in mice following exposure to 30 d of continuous AAE. Peripheral function and sound sensitivity in auditory midbrain neurons improved following exposure to both types of AAE. However, exposure to a novel, temporally complex AAE more strongly improved a measure of temporal processing acuity, neural gap-in-noise detection in the auditory midbrain. These experiments suggest that targeted sound therapy may be harnessed to improve hearing outcomes for children suffering from congenital SNHL.
Nutritional quality and carbon footprint of university students’ diets: results from the EHU12/24 study

Abstract Objective: To evaluate diets in terms of nutritional characteristics and quality from the perspectives of health, greenhouse gas emissions (GHGE) and possible associations with each other in a representative sample of students at a public university. Design: Cross-sectional. Dietary intake was evaluated with a validated FFQ, and diet quality was assessed through the Healthy Eating Index (HEI-2010) and MedDietScore (MDS). GHGE data were obtained from the literature. In addition, sex, socio-economic status (SES) and body fat (BF) status were analysed as covariates. Setting: Basque Autonomous Community, Spain. Participants: Totally, 26 165 healthy adults aged 18–28 years. Results: Student diets were characterised by low consumption of carbohydrates (38·72 % of total energy intake (TEI)) and a high intake of lipids (39·08 % of TEI). Over half of the participants had low dietary quality. The low-emitting diets were more likely to be consumed by subjects with low HEI-2010 scores (β: 0·039 kg eCO2/1000 kcal/d) and high MDS scores (β: −0·023 kg eCO2/1000 kcal/d), after controlling for sex, SES and BF status. Both the low-emitting and healthy diets were more likely to be consumed by women and by those with normal BF percentage. Conclusions: UPV/EHU university students’ diets were characterised by moderate quality from a nutritional perspective and moderate variation in the size of carbon footprints. In this population, diets of the highest quality were not always those with the lowest diet-related GHGE; this relationship depended in part on the constructs and scoring criteria of diet quality indices used.
A Psychoeducational Group Intervention for Nurses: Rationale, Theoretical Framework, and Development

OBJECTIVE Nursing is a demanding profession with constant stressors, which makes nurses vulnerable to the detrimental effects of high stress, burnout, and compassion fatigue. There is a need for a multidimensional group intervention facilitated by a licensed mental health professional to improve mental health and well-being in nurses. An intervention called RISE, which is an acronym for resilience, insight, self-compassion, and empowerment, was developed to promote self-care, protect against burnout, and improve indicators of well-being among nurses. We explain the rationale, theoretical framework, and development of RISE. METHODS RISE is based on an integrative theoretical framework of mindfulness, acceptance and commitment therapy, and cognitive-behavioral therapy. It consists of eight psychoeducational group sessions with topics related to the four RISE themes of resilience, insight, self-compassion, and empowerment. RESULTS RISE is a contribution to the literature on well-being interventions for nurses. It will further the understanding of effective interventions to mediate the detrimental effects of stress and burnout in nursing and to improve the mental health and well-being of nurses amid the complex interplay of factors at the individual, unit, and organizational levels. CONCLUSIONS As an approach that combines education with therapeutic process and support to improve coping and well-being inside and outside of the workplace, RISE addresses the underlying causes and effects of high stress, burnout, and compassion fatigue.
Energy values of crude glycerin for broilers

The energetic values of crude glycerin (CG) were determined for broilers at different ages using the method proposed by Matterson and by polynomial regressions. Two trials were performed with broilers from 11 to 21 and from 31 to 41 days of age. The birds were distributed in a completely randomized experimental design with a reference ration (RR), without CG, and three ration tests with replacement of 5%, 10%, and 15% of RR by CG. The metabolizable energy values were calculated by the Matterson method, and the apparent metabolizable energy (AME) values were used in polynomial regression analysis. The mean values of AME, apparent corrected for nitrogen balance (AMEn), metabolizable coefficient of gross energy (CAMEB), and corrected for nitrogen balance (CAMEBn) of CG, for the phase from 11 to 21 days by the Matterson method were 10.08 MJ kg, 10.04 MJ kg, 67.06%, and 66.74%, respectively. The inclusion of CG presented an increasing linear effect for CAMEB and CAMEBn in this period. From 31 to 41 days, these values were 10.38 MJ kg, 10.27 MJ kg, 69.02%, and 62.24%, respectively. The predicted AMEn value through the polynomial regression equations was 10.49 MJ kg and 10.18 MJ kg, respectively. According to the equations proposed by Matterson, the crude glycerin EMAn values for broilers from 11 to 21 and 31 to 41 days of age were 10.04 MJ kg and 10.26 MJ kg, respectively. According to Adeola's method the AMEn values were 10.49 and 10.20 MJ kg for each phase.
An adaptive congestion control technique for improving TCP performance over ad-hoc networks

Identifying the occurrence of congestion in a Mobile Ad-hoc Network (MANET) is a major task. The inbuilt congestion control techniques of existing Transmission Control Protocol (TCP) designed for wired networks do not handle the unique properties of shared wireless multi-hop link. There are several approaches proposed for detecting and overcoming the congestion in the mobile ad-hoc network. In this paper we present a Modified AD-hoc Transmission Control Protocol (M-ADTCP) method where the receiver detects the probable current network status and transmits this information to the sender as feedback. The sender behavior is altered appropriately. The proposed technique is also compatible with standard TCP .
Supporting Information S 1 Mathematical Description of the Model

This section provides a more mathematically detailed description of our the Dirichlet process prior and the n-gram-based likelihood of our model introduced in §3.3. We again start with the prior (S1.1), and then discuss the likelihood (S1.2). Finally, S1.3 introduces the inference algorithm we adopt to approximate the posterior distribution. We adopt the following mathematical notations in addition to the ones introduced in §3.2. We use p(X = x) to denote the probability of the random variable X taking the value x. For an arbitrary probability distribution G, X ∼ G denotes “the random variable X is distributed according to G”. We also adopt standard notation from formal language theory. For any arbitrary string of symbols a := (a1, . . . , al), |a| denotes the length l of a. We refer to the empty string by ε and the inventory of phonetic segments by Σ. The function tail(·) takes an arbitrary string a as its input and outputs the substring (a2, . . . , al), dropping the first symbol a1. We also use sfxk(a) (k ≤ |a|) to refer to the last k symbols of a (al−k+1, . . . , al). sfxk(·) is defined by |a| − k recursive applications of tail(·).
Fermented Fish ( Ngari ) of Manipur – Preparation Technique and its Potential as a Functional Food Ingredient

Ngari is a non-salted fermented fish product of Manipur. Sundried Puntius sophore (Ham.) are fermented anaerobically with no intentional addition of starter culture for 4 to 12 months. LAB, Bacillus and yeast were involved in its fermentation. They are prepared at household level and marketed locally. Ngari are good source of protein, amino acids and minerals. The product has potential probiotic properties, antioxidant and antihypertensive characteristics. However, the fermented product if not processed hygienically can pose threat to food borne illness due to cross contamination. This review study is to know the processing technique and potential health benefits of Ngari. © 2015 Elixir All rights reserved. ARTICLE INFO Article history: Received: 2 July 2015; Received in revised form: 1 August 2015; Accepted: 14 August 2015;
Relationship between organizational justice and organizational commitment of staff in Payame Noor universities

Employees play a substantive role in taking many decisions in organizations. Whether the decisions made with regards to the employees are just is occasionally questioned. The behaviors of the employees against justice began to be analyzed, as justice being taken seriously in organization. (Serdar ÇÖP et al.,2008) Without a perception of justice and fairness, organizations will have great difficulty in motivating and guiding employees. Organizational fairness demonstrates the administration’s respect for employees and produces a bridge of trust that ultimately strengthens the employees’ commitment to the organization employees who feel that their employing organization is fair and just in dealing with workers will encourage trust and loyalty . , and this will ultimately increase the organizational commitment of the worker. ( Lambert,2003) © 2014 Elixir All rights reserved ARTICLE INF O
Design and FPGA Control of Modular Multilevel Inverter for Photovoltaic Applications

Recently, modular multilevel inverter(MMLI) have gained interest for photovoltaic applications. This topology minimizes the total harmonic distortion both at the DC and AC side and reduces the voltage stress across the devices for high voltage applications compared to the conventional multilevel inverter. This paper explains the significance of a MMLI by employing phase shift PWM technique. This control algorithm is implemented in SPARTAN/FPGA board. The important aspect of this paper is the issues related to capacitor voltage balancing is addressed. The MMLI is powered by PV source and the modeling of PV alongwith MPPT is implemented in MATLAB. The validity of the proposed modular MLI topology is confirmed by simulation and experimentation. © 2016 Elixir All rights reserved. Elixir Elec. Engg. 100 (2016) 43768-43773 Electrical Engineering Available online at www.elixirpublishers. com (Elixir International Journal)
Simultaneous determination of residues of pyrethroid pesticides in aquatic products by gas chromatograohy

Gas chromatography with electron capture detection method was developed for the determination of 6pyrethroids residues in aquatic products.The sample was extracted with cyclohexane:ethyl acetate(1:1,V:V),separated with liquid-liquid partition and cleaned up with Florisil solid-phase extraction cartridges using acetone:n-hexane(1:9,V:V)as eluent.The eluent was blown to dryness under a stream of nitrogen,was then injected into the GC system to quantitative analysis.Under the optimal conditions,the detection limits of this method for 6pyrethroids residues were 1.1～2. 4μg/kg,with the relative standard deviations ranging from 1.1% ～5.2%(n=5) and the recovery rates were from 85.7%～108.1%.
A COMPARISON OF THE ESTIMATION OF THE BASAL CARDIAC OUTPUTFROMA LINEAR FORMULA ANDTHE " CARDIAC INDEX " 1 By

It is customary to express the cardiac output of man in units of body size, usually in the form of the cardiac index which is simply the gross cardiac output in liters of blood per minute divided by the surface area of the body. The use of the cardiac index implicitly assumes that the cardiac output normally is directly proportional to the surface area of the body with the prediction line going through the origin of the X and Y axes. Tanner (1, 2) has recently pointed out that errors arise in using cardiac index as a criterion for prediction of cardiac output when strict proportionality is not present. In this situation, the regression line which describes the best linear fit for any group of data differs from the line defined by the cardiac index. Under these conditions the cardiac index will overestimate or underestimate the expected value for an individual in the extreme range of the body size and comparisons of population groups with reference to the cardiac index will be inexact unless the surface areas of the two population groups are identical. Tanner (1) used the relationship of stroke volume to body weight as an example of such errors but did not provide an analysis of the errors involved in the cardiac index. A large percentage of the cardiac output data in the literature is expressed in terms of the cardiac index. Recently standards for the low-frequency, critically damped ballistocardiograph have been published exclusively in terms of this ratio by Gregersen and Nickerson (3). It is the purpose of this paper to examine the validity of the cardiac index as a standard with special reference to its usefulness in predicting the cardiac output of individuals.
An Effective Heterogeneous Ozone-Based Advanced Oxidation Process in Acidic Solution— Ti-MCM-41/H2O2/O3

ABSTRACT A useful ozone-based advanced oxidation process in acidic solution- Ti-MCM-41/H2O2/O3 was studied, and acetic acid (HAc) was selected to be degraded because it is a hydroxyl radical-probe compound in ozonation. The results showed that only Ti-MCM-41/H2O2/O3 could effectively degrade HAc at initial pH 3.0, and that other oxidative processes such as O3, H2O2/O3 Ti-MCM-41/O3 and MCM-41/H2O2/O3, all could not, indicating the coexistence of Ti-MCM-41 and H2O2 was necessary for the generation of hydroxyl radicals under the experimental conditions. The optimization of parameters indicated that the rate of generation of hydroxyl radicals could be regulated by the amount of Ti-MCM-41, and that the amount of hydroxyl radicals could be controlled by the concentration of H2O2. The preceding results are of significance for effective treatment of acidic refractory wastewater.