Miracle-dz/UniFAR-FTUs huggingface dataset:
De-Escalation Strategies for Human Papillomavirus-Associated Oropharyngeal Squamous Cell Carcinoma—Where Are We Now?

The prevalence of oropharyngeal squamous cell carcinoma has been increasing in North America due to human papillomavirus-associated disease. It is molecularly distinct and differs from other head and neck cancers due to the young population and high survival rate. The treatment regimens currently in place cause significant long-term toxicities. Studies have transitioned from mortality-based outcomes to patient-reported outcomes assessing quality of life. There are many completed and ongoing trials investigating alternative therapy regimens or de-escalation strategies to minimize the negative secondary effects while maintaining overall survival and disease-free survival. The goal of this review is to discuss the most recent advancements within the field while summarizing and reviewing the available evidence.
Identification and Distribution of Human-Biting Ticks in Northwestern Spain

Simple Summary We conducted a tick surveillance study in northwestern Spain. Nymphs of Ixodes ricinus were the most frequently collected. Rhipicephalus bursa, Rhipicephalus sanguineus sensu lato (s.l.), Hyalomma marginatum, Hy. lusitanicum, Dermacentor marginatus, D. reticulatus and Haemaphysalis punctata were also found, with adults as the main stage. The number of collected Hyalomma spp. and R. bursa has been progressively increasing over time. Although bites occurred throughout the year, the highest number of incidents was reported from April to July. The distribution patterns of the tick species were different between the north and the south of the region, which was related to cases detected in humans of the pathogens they carried. Adult men were more likely to be bitten by ticks than women. Ticks were most frequently removed from adults from the lower limbs, while for children, they were mainly attached to the head. Epidemiological surveillance is essential given the increase in tick populations in recent years. Abstract Ticks transmit a wide diversity of pathogens to a great variety of hosts, including humans. We conducted a tick surveillance study in northwestern Spain between 2014 and 2019. Ticks were removed from people and identified. Tick numbers, species, development stages, the timeline, seasonal and geographical distribution and epidemiological characteristics of people bitten by ticks were studied. We collected ticks from 8143 people. Nymphs of I. ricinus were the most frequently collected. Rhipicephalus bursa, R. sanguineus s.l. , Hy. marginatum, Hy. lusitanicum, D. marginatus, D. reticulatus and H. punctata were also found, with adults as the main stage. The number of collected Hyalomma spp. and R. bursa has been progressively increasing over time. Although bites occurred throughout the year, the highest number of incidents was reported from April to July. The distribution patterns of the tick species were different between the north and the south of the region, which was related to cases detected in humans of the pathogens they carried. Adult men were more likely to be bitten by ticks than women. Ticks were most frequently removed from adults from the lower limbs, while for children, they were mainly attached to the head. Epidemiological surveillance is essential given the increase in tick populations in recent years, mainly of species potentially carrying pathogens causing emerging diseases in Spain, such as Crimean–Congo hemorrhagic fever (CCFH).
Disasters and indigenous peoples: A critical discourse analysis of the expert news media

Attempts to shift the ways disasters have traditionally been managed away from authoritarian, top-down approaches toward more bottom-up and inclusive processes often involve incorporating viewpoints from marginalised and vulnerable groups. Recently as part of this process, there have been calls for greater inclusion of Indigenous peoples in disaster management. In theory, this also suggests a shift in power structures, towards recognising Indigenous peoples as experts in disaster management. However, in popular imagination and policy Indigenous peoples often appear to be caricatured and misrepresented, for instance through tropes of Indigenous peoples as custodians of the environment or especially vulnerable to environmental change. These framings matter because they can result in disaster management policies and practices that do not capture Indigenous peoples’ complex realities. However, these framings have not been analysed in the context of disasters. In this article, we aim to better understand these framings through a critical discourse analysis of how Indigenous peoples in disasters are represented in the expert news media. We identify five discourses, including a dominant one of disasters as natural phenomena to be addressed through humanitarianism and technocratic interventions. Such discourses render Indigenous peoples helpless, depoliticize disasters and are justified by framing governments and NGOs as caring for Indigenous peoples. However, we also identify competing discourses that focus on systems of oppression and self-determination in disaster management. These discourse recognise disasters as political and include discussion of the role of colonialism in disaster creation. As care emerged as a means through which intervention was justified, we conclude by asking questions of who is cared for/about in disasters and how that care is performed.
Update on the Epidemiological Features and Clinical Implications of Human Papillomavirus Infection (HPV) and Human Immunodeficiency Virus (HIV) Coinfection

Human papillomavirus (HPV) infection is the most common sexually transmitted infection (STI) worldwide. Although most HPV infections will spontaneously resolve, a considerable proportion of them will persist, increasing the risk of anogenital dysplasia, especially within certain populations, such as patients infected with human immunodeficiency virus (HIV). Furthermore, high-risk oncogenic HPV types (HR-HPV) are the main cause of cervix and other anogenital cancers, such as cancer of the vagina, vulva, penis, or anus. HIV and HPV coinfection is common among people living with HIV (PLWH) but disproportionally affects men who have sex with men (MSM) for whom the rate of persistent HPV infection and reinfection is noteworthy. The molecular interactions between HIV and HPV, as well as the interplay between both viruses and the immune system, are increasingly being understood. The immune dysfunction induced by HIV infection impairs the rate of HPV clearance and increases its oncogenic risk. Despite the availability of effective antiretroviral therapy (ART), the incidence of several HPV-related cancers is higher in PLWH, and the burden of persistent HPV-related disease has become a significant concern in an aging HIV population. Several public health strategies have been developed to reduce the transmission of HIV and HPV and mitigate the consequences of this type of coinfection. Universal HPV vaccination is the most effective preventive tool to reduce the incidence of HPV disease. In addition, screening programs for HPV-related cervical and vulvovaginal diseases in women are well-recognized strategies to prevent cervical cancer. Similarly, anal dysplasia screening programs are being implemented worldwide for the prevention of anal cancer among PLWH. Herein, the main epidemiological features and clinical implications of HIV and HPV coinfection are reviewed, focusing mainly on the relationship between HIV immune status and HPV-related diseases and the current strategies used to reduce the burden of HPV-related disease.
Diguanylate Cyclase (DGC) Implicated in the Synthesis of Multiple Bacteriocins via the Flagellar-Type III Secretion System Produced by Pectobacterium carotovorum subsp. carotovorum

The plant pathogen Pectobacterium carotovorum subsp. carotovorum (previously Erwinia carotovora subsp. carotovora) causes soft rot and stem rot diseases in a variety of crops, including Chinese cabbage, potato, and tomato. The flagellar-type III secretion systems were used by Pcc’s virulence mechanism to export proteins or bacteriocins to the outside of the cell. DGC, a virulence factor that cyclizes c-di-GMP, a common secondary signal in physiological processes and toxin control systems of many bacteria, was discovered in Pcc’s genomic DNA. The dgc gene in Pcc was blocked using the method of homologous recombination in our study. In the in vivo setting, the results demonstrated that the dgc knockout strain does not release low molecular weight bacteriocins. The bacteriocin gene (carocin S2, carocin S3, carocin S4) and the flagellar-type III secretion system genes were also unable to be transcribed by the dgc knockout strain in the transcription experiment. We also observed that the amount of bacteriocin expressed changed when the amount of L-glutamine in the environment exceeded a particular level. These data suggested that L-glutamine influenced physiological processes in Pcc strains in some way. We hypothesized a relationship between dgc and the genes involved in Pcc LMWB external export via the flagellar-type secretion system based on these findings. In this study, the current findings led us to propose a mechanism in which DGC’s cyclic di-GMP might bind to receptor proteins and positively regulate bacteriocin transcription as well as the synthesis, mobility, and transport of toxins.
Temporomandibular disorder and headache prevalence: A systematic review and meta-analysis

Background: Temporomandibular disorders (TMD) and headaches are prevalent among the global population. Patients often suffer from both conditions, and they are likely to be associated in a bidirectional way. However, the nature of the association remains unclear. Understanding the epidemiological aspects of the relationship between these conditions could have important clinical implications. Objective: To evaluate the prevalence of headaches in TMD patients as well as the prevalence of TMD in patients who suffer from headaches. Method: A systematic literature search was conducted using electronic databases. Studies published in English and those that used an acknowledged diagnostic criteria for TMD and headaches were included. Study quality was assessed using the Newcastle-Ottawa scale and meta-analyses were performed to generate pooled prevalence estimates. Result: Thirty-one studies met the selection criteria for the review; 16 studies evaluated the prevalence of headache in TMD patients and 15 studies evaluated the prevalence of TMD in headache patients. The included studies were of moderate-to-high quality. Meta-analyses revealed moderate-to-large heterogeneities across included studies. Pooled prevalence estimates from meta-analyses indicated similar rates of headaches in TMD patients and of TMD in headache patients (61.58%, 95% CI 45.26–76.66 and 59.42%, 95% CI 51.93–66.60, respectively). Migraines were more commonly observed in TMD patients (40.25%, 95% CI 35.37–45.23) compared to tension-type headaches (18.89%, 95% CI 12.36–26.44). The prevalence of headaches was particularly high in painful-TMD (82.80%, 95% CI 75.41–89.10). Conclusion: Despite large variance in prevalence rates across included studies, this review suggests headache and TMD frequently co-occur, particularly in the case of migraines and muscle related TMD. This association has important clinical, pathophysiological and therapeutic implications.
Design of Chopsticks-Shaped Heating Resistors for a Thermal Inkjet: Based on TaN Film

Efficient printing frequency is critical for thermal bubble inkjet printing, while the difficulty lies in the structural design and material selection of the heating resistors. In this paper, a TaN film was used as the main material of the heating resistors, and two TaN films were placed in parallel to form the chopsticks-shaped structure. The heating time was divided into two sections, in which 0–0.1 μs was the preheating and 1.2–1.8 μs was the primary heating. At 1.8 μs, the maximum temperature of the Si3N4 film could reach about 1100 °C. At the same time, the SiO2 film was added between the TaN film and Si3N4 film as a buffer layer, which effectively avoided the rupture of the Si3N4 film due to excessive thermal stress. Inside the inkjet print head, the maximum temperature of the chamber reached about 680 °C at 2.5 μs. Due to the high power of the heating resistors, the working time was greatly reduced and the frequency of the inkjet printing was effectively increased. At the interface between the back of the chip and the cartridge, the SiO2 film was used to connect to ensure a timely ink supply. Under the condition of 12 V at 40 kHz, the inkjet chip could print efficiently with 10 nozzles at the same time. The inkjet chip proposed in this paper is not limited to only office printing, but also provides a new reference for 3D printing, cell printing, and vegetable and fruit printing.
The Application of Artificial Intelligence Technology in Art Teaching Taking Architectural Painting as an Example

In the current era of technology, artificial intelligence has grown rapidly in such a way that it has established its presence in all fields. The purpose of artificial intelligence is to reduce human intervention and complete tasks with an enhanced result. In this research, we are going to study the application of artificial intelligence technology in art teaching, taking architectural painting as an example. Architectural painting is a type of painting that focuses only on architecture, including indoor and outdoor views of the buildings. In earlier stages, architecture was shown only in the background of paintings that had different objects as the main subject. Later, architecture itself became a mainstream genre in the field of painting. As has been shown by other researchers, the latest technologies such as Internet technology, wireless sensor networks (WSNs), and artificial intelligence like deep learning technologies are deployed in art teaching. Artificial intelligence has made teaching easier. This proposed system makes use of Internet technology, WSNs, artificial intelligence, and lightweight deep learning models in the field of art teaching. The teaching method is enhanced by adapting to this new technology. For performing the analysis of the proposed system, the Limited Broyden–Fletcher–Goldfarb–Shanno (L-BFGS) art algorithm is implemented. This L-BFGS algorithm focuses on finding the local minima in any given application. In this art teaching of architectural painting, the proposed algorithm will aid in explaining the minute works to be noted while doing the artwork. The proposed algorithm is then compared with the traditional Gradient Descent, Adam, and Adadelta algorithms. From the results, it can be observed that the proposed algorithm has achieved accuracy of 97% and 98% in the training and testing phases, respectively.
BSNet: Dynamic Hybrid Gradient Convolution Based Boundary-Sensitive Network for Remote Sensing Image Segmentation

Boundary information is essential for the semantic segmentation of remote sensing images. However, most existing methods were designed to establish strong contextual information while losing detailed information, making it challenging to extract and recover boundaries accurately. In this article, a boundary-sensitive network (BSNet) is proposed to address this problem via dynamic hybrid gradient convolution (DHGC) and coordinate sensitive attention (CSA). Specifically, in the feature extraction stage, we propose DHGC to replace vanilla convolution (VC), which adaptively aggregates one VC kernel and two gradient convolution kernels (GCKs) into a new operator to enhance boundary information extraction. The GCKs are proposed to explicitly encode boundary information, which is inspired by traditional Sobel operators. In the feature recovery stage, the CSA is introduced. This module is used to reconstruct the sharp and detailed segmentation results by adaptively modeling the boundary information and long-range dependencies in the low-level features as the assistance of high-level features. Note that DHGC and CSA are plug-and-play modules. We evaluate the proposed BSNet on three public datasets: the ISPRS 2-D semantic labeling Vaihingen, the Potsdam benchmark, and the iSAID dataset. The experimental results indicate that BSNet is a highly effective architecture that produces sharper predictions around object boundaries and significantly improves the segmentation accuracy. Our method demonstrates superior performance on the Vaihingen, the Potsdam benchmark, and the iSAID dataset in terms of the mean $F_{1}$ , with improvements of 4.6%, 2.3%, and 2.4% over strong baselines, respectively. The code and models will be made publicly available.
Effect of a Dynamic Climate Control on Energy Saving, Yield and Shelf Life of Spring Production of Bell Peppers (Capsicum annuum L.)

Summary Bell pepper ‘Fiesta’ (Capsicum annuum L.) was grown in a novel dynamic climate concept called ‘IntelliGrow’ together with a number of potted plants aiming to save energy under low light conditions and to optimise photosynthesis (and thereby carbon gain that can be used for growth) under high light conditions. The dynamic climates utilize the plants ability to increase the photosynthesis and productivity under adequate light conditions by allowing temperature to increase while supplying the plants with extra CO 2 . Energy is saved by allowing the temperature to decrease to lower levels than usual at low light conditions, when the temperature response curve of photosynthesis is very flat. Both temperature and CO 2 is determined by the light level (light dependent temperature and CO2 increase in the climate computer). It is possible to reduce the energy use needed for bell pepper growing by up to 21 % in this experiment depending on climate control strategy. Temperatures below 17 °C results in reduced fruit quality in terms of size and quality and increased risk of grey mould and also a delay in the harvest start. On the other hand the total number of fruits was not affected in a similar way. The standard climate 21/19 day/night with 600 ppm CO 2 in light and the dynamic climate using 80 % photosynthesis and a minimum temperature set point of 17 °C, especially in combination with short peaks of higher night temperature gave the same or better harvest and approximately the same quality. The fruits in the warmest climate, however, had a slightly lower dry matter-%. There were limited damages (spots, sun burns) due to the relatively higher temperatures during the day even thought the air temperature was allowed to rise to 30 °C during the days. The increased CO 2 level might have alleviated some of the potential damages due to high fruit temperatures. The major problem was remains of the flowers on the fruits, which created an entry point for grey mould. The post harvest quality of the fruits was therefore poorer in the dynamic climates due to infection with Botrytis primarily through the flowers and secondarily through the fruit stem. A modified energy saving strategy therefore requires a change in harvest procedure to remove flower remains.
Independent comparison of popular DPI tools for traffic classification

L’any 2014 uns doctorants de l’UPC van modificar un software anomenat Volunteer-Based System (VBS)[1] perque no nomes captures paquets i els agrupes en traces, sino perque les traces guardessin informacio sobre el proces que l’havia generat. Usant el VBS van crear una gran base de dades amb trafic que havien generat d’aplicacions especifiques per a poder realitzar un estudi comparatiu de les diverses eines DPI (Deep Package Inspection)[2] que hi havia al mercat. Es van analitzar un total de 7 eines i els resultats obtinguts van tenir una gran repercusio dins del mon de l’analisi de paquets [3]. La finalitat d’aquest projecte de final de grau es ajudar a millorar i ampliar aquest software perque pugui capturar paquets de mes aplicacions i aixi poder realitzar estudis mes amplis i acurats. L’objectiu principal es aconseguir que el software VBS funcioni no nomes en sistemes Windows i Linux, sino tambe en sistemes Mac OS X ja que en els ultims anys hi ha hagut un increment dels ordinadors i dispositius que usen aquest sistema operatiu.
Developmental Patterns of Accentual Phrases in Korean Children’s Speech

The Accentual Phrase (AP) in Korean is said to be conditioned by the glottal status in the AP-initial segments, with the canonical shape of LHLH, when the initial segment of AP bears [-stiff vocal cords]. While the tonal pattern of adult speakers has been examined extensively, relatively few studies exist that examine the tonal patterns realized by children’s speech. The paper examines the developmental trajectory of the canonical tonal shape of AP in Korean by analyzing speech samples of children aged 3 to 10 years old in a publicly available corpus. The VOT of the initial plain stop was also examined to see whether the tonal shape of the AP in children’s speech was affected by the phonetic properties of the initial segment. The results showed that the tonal contours of the Accentual Phrases were best understood to be phonologically encoded and produced by children across most age groups.
An Exploration of Listeria monocytogenes, Its Influence on the UK Food Industry and Future Public Health Strategies

Listeria monocytogenes is a Gram-positive intracellular pathogen that can cause listeriosis, an invasive disease affecting pregnant women, neonates, the elderly, and immunocompromised individuals. Principally foodborne, the pathogen is transmitted typically through contaminated foods. As a result, food manufacturers exert considerable efforts to eliminate L. monocytogenes from foodstuffs and the environment through food processing and disinfection. However, L. monocytogenes demonstrates a range of environmental stress tolerances, resulting in persistent colonies that act as reservoirs for the reintroduction of L. monocytogenes to food contact surfaces and food. Novel technologies for the rapid detection of L. monocytogenes and disinfection of food manufacturing industries have been developed to overcome these obstacles to minimise the risk of outbreaks and sporadic cases of listeriosis. This review is aimed at exploring L. monocytogenes in the UK, providing a summary of outbreaks, current routine microbiological testing and the increasing awareness of biocide tolerances. Recommendations for future research in the UK are made, pertaining to expanding the understanding of L. monocytogenes dissemination in the UK food industry and the continuation of novel technological developments for disinfection of food and the food manufacturing environment.
Prosodic focus marking in Canadian English

The current study investigated how broad focus, narrow focus and given information are produced in Canadian English. Given previous findings that showed different varieties of English signal information structure differently, we hypothesized that the effects of focus on acoustic correlates involving duration, f0, and intensity would manifest differently in Canadian English than in Mainstream American English (MAE). Thirty-eight native speakers of Canadian English produced 24 short transitive sentences in different focus conditions: broad focus and narrow focus in different locations (Subject, Verb, Object). A total of 2,736 words were analyzed. While some acoustic correlates such as duration and maximum intensity replicated the same patterns as previous findings in MAE, mean intensity and f0 measures showed different patterns. These results suggest that speakers of Canadian English may employ a different set of acoustic correlates from speakers of MAE. The study sheds light on the role of dialect in the production of focus and givenness and expands our knowledge about the fine-grained details of the phonetic realization of prosodic focus marking in English.