Miracle-dz/UniFAR-FTUs huggingface dataset:
Cytochrome 4Z1 Expression Connotes Unfavorable Prognosis in Ovarian Cancers

Background and Objective: Ovarian cancer is a leading cause of death in females. Since its treatment is challenging and causes severe side effects, novel therapies are urgently needed. One of the potential enzymes implicated in the progression of cancers is Cytochrome 4Z1 (CYP4Z1). Its expression in ovarian cancer remains unknown. Therefore, the current study aims to assess CYP4Z1 expression in different subtypes of ovarian cancers. Materials and Methods: Immunohistochemistry was used to characterize CYP4Z1 expression in 192 cases of ovarian cancers along with eight normal ovarian tissues. The enzyme’s association with various clinicopathological characteristics and survival was determined. Results: CYP4Z1 was strongly expressed in 79% of ovarian cancers, compared to negative expression in normal ovarian samples. Importantly, significantly high CYP4Z1 expres-sion was determined in patients with advanced-stage cancer and a high depth of invasion (p < 0.05). Surprisingly, CYP4Z1 expression was significantly associated with a low patient survival rate. Univariate analysis revealed that patient survival was strongly associated with CYP4Z1 expression, tumor stage, depth of invasion, and lymph node metastasis (p < 0.05). Multivariate analysis showed that only CYP4Z1 expression was significantly associated with patient survival (p < 0.05). Conclusions: CYP4Z1 expression is correlated with shorter patient survival and has been identified as an independent indicator of a poor prognosis for ovarian cancer patients.
Striving Adolescent Readers’ Motivation

ABSTRACT This review of research examines definitions of reading motivation, instruments for measuring reading motivation, reading motivation interventions and instructional designs, and student outcomes related to reading motivation. The population for this review was restricted to middle or high school students who: (a) have a qualifying disability in reading, (b) are identified as having “reading difficulties,” or (c) present characteristics of dyslexia but are otherwise not identified. Definitions of reading motivation were generally ambiguous or ill-defined in relationship to the construct being measured. A variety of established reading motivational scales were identified, as well as some that were author-constructed. Although evidence from previous studies demonstrates a positive contribution of reading motivation to student outcomes, there were less significant relationships found between student outcomes and those students with reading disabilities or reading difficulties.
Effect of a Discontinuous Ag Layer on Optical and Electrical Properties of ZnO/Ag/ZnOStructures

ZnO/Ag/ZnO nanolaminate structures were deposited by consecutive RF sputtering at room temperature.The optical transparency, sheet resistance, and figure of merit are determined in relation to the deposition time of Ag and to the film thickness of the ZnO top layer. An improved transmittance has been found in the visible spectral range of the ZnO/Ag/ZnO structure compared to ZnO multilayers without Ag. High transmittance of 98% at 550 nm, sheet resistance of 8 Ω/sq, and figure of merit (FOM) of 111.01 × 10−3 Ω−1are achieved for an optimized ZnO/Ag/ZnO nanolaminate structure. It is suggested that the good optical and electrical properties are due to the deposition of the discontinuous Ag layer. The electrical metallic type conductivity is caused by planar located silver metal granules. The deposition of a discrete layer of Ag nano-granules is confirmed by atomic force microscopy (AFM) and cross-section high-resolution transmission electron microscopy (HRTEM) observations.
Complete skull of Bothriogenys fraasi (Mammalia, Artiodactyla, Anthracotheriidae) from the Early Oligocene, Fayum, Egypt

Bothriogenys is an endemic African anthracothere (Mammalia, Artiodactyla), which was first documented at the beginning of the last century by Schmidt in 1913. It is one of the most common genera and species that were unearthed from Early Oligocene deposits of North Africa, like those of the Fayum Depression, Egypt. It has been thought that the genus Bothriogenys probably give rise to the Early Miocene Brachyodus that dispersed to Europe and Asia around 20 million years ago. Here, we describe a complete skull of B. fraasi. The specimen is a nearly complete cranium with right canine, left and right upper first premolar‐upper third molar. The new skull has two mesial cristae on the upper premolars, three cristules on the metaconule and the upper fourth premolar has three roots. The main palatine foramina are located at the level of the mesial border of the upper fourth premolar and the internal choanae open well behind the upper molar. The cranial bones and the dentition indicate that Bothriogenys is located at the basal part of the subfamily Bothriodontinae and very close to early Miocene Brachyodus. If so Bothriogenys was likely among the first anthracotheriids to enter Africa. Continued anthracothere development and evolution ultimately gave rise to Early Miocene Brachyodus.
Spatiotemporal change in duration of households with every member out-of-home: a case in Kumamoto, Japan

ABSTRACT Nobody-at-home situations can cause several problems, such as home-delivery failures and burglaries. A recent study demonstrated temporal profiles of households with every member out-of-home (HEMO) situation by using household travel surveys. However, the spatial distribution of HEMO and its transition were not examined, and the effect of household attributes on HEMO was not analyzed statistically. In this study, the spatiotemporal variation in HEMO duration was investigated to address this gap, and the duration was analyzed using two econometric models. The 1984, 1997, and 2012 household travel surveys from Kumamoto, Japan, were used for the spatiotemporal visualization. In addition, the Tobit model and time allocation model were developed to statistically determine the reason for the variation in duration. The average HEMO duration increased by more than 1 h between 1984 and 2012. The downtown area revealed a longer HEMO duration, and the area with a longer duration expanded to rural areas between 1984 and 2012. The estimated econometric models revealed the statistical impacts of household attributes on HEMO duration. The HEMO duration of single-person households with a worker or student was long, and that of households with a working husband and homemaker wife was short. The spatiotemporal distribution of HEMO durations presented in this paper has the potential to be used in future urban studies, including those on the logistics of home-delivery, home-visiting survey design, crime prevention, and energy research.
Forgotten forbs: Standard vegetation surveys underrepresent ecologically and culturally important forbs in a threatened grassland ecosystem

Forbs are a culturally and ecologically important yet poorly studied component of the Pacific Northwest Bunchgrass (PNB) ecosystem of western North America. Because many PNB forbs emerge early in the spring and senesce at the onset of summer, typical vegetation surveys, which occur mid‐summer, likely underrepresent forbs. We evaluated how the timing of vegetation sampling affected estimates of perennial forb abundance, richness, and floral density, with a focus on species that are culturally significant to Indigenous people of the region. We sampled 29 plots three times: mid‐summer (July), as well as 7 (May) and 12 (April) weeks prior. Timing had large effects on estimates, with significant declines in forb richness (42%), cover (80%), and floral density (95%) between April and July. The density of Camassia quamash and Lomatium cous, two culturally important species, declined 91% and 96%, respectively, from April to July. Nearly 65% of forbs had documented uses by Plateau Tribes. The consequences of biased estimates are significant and (1) limit our understanding of fundamental ecological processes and interactions; (2) hinder effective conservation and management because we lack information on forb abundance, status, and trends, and (3) result in disproportionately negative impacts to Indigenous communities as many forbs are important for subsistence and ceremonial purposes. Vegetation sampling during the spring months coincident with peak forb abundance, in addition to summer sampling would provide more appropriate data with which to evaluate and characterize PNB vegetation dynamics and improve our understanding, management, and conservation of native forbs.
Fecal Coliforms and Total Coliforms Removal in Water Using Radio-Frequency (RF) Plasma System

A radio-frequency plasma system (RF) was used to investigate the removal of microorganisms from water.Plasma generated by RF radiation can produce active compounds (H•, •OH, H2O2, O3, etc.) that have a highoxidation potential and can kill microorganisms present in water (fecal coliforms and total coliforms). Thefrequency of the plasma system was set to 3.0, 3.3 and 3.7 MHz and applied to river water for 60 minutes. Theresults show that in all runs, the pH of the water produced was in the range from 7.4 to 7.9. The removalefficiencies of fecal coliforms achieved were between 83.75 and 95% and were higher than the removalefficiencies of total coliforms, which were between 82.61 and 93.48%. Meanwhile, the death rate (kD) of fecalcoliforms wasfaster than that of total coliforms. Therefore, the removal of total coliforms is the key to removingmicroorganisms fromwater. RF plasma treatment can be used for treatment of drinking water to decreasemicroorganisms.
Double Valve Replacement in a Patient With Hunter Syndrome

Hunter syndrome is a rare disorder in which affected patients have significant airway abnormalities (macroglossia, small mouth opening, and supraglottic narrowing) that complicate their management. Deposition of glycosaminoglycans in the heart leads to cardiomyopathy, and cardiac valve dysplasia that can lead to valvular stenosis or regurgitation or both, necessitating valve replacement. Management of patients with Hunter syndrome is complex and needs a multidisciplinary team approach. Mechanical valve replacement is a suitable treatment option.
A Panax quinquefolius-Based Preparation Prevents the Impact of 5-FU on Activity/Exploration Behaviors and Not on Cognitive Functions Mitigating Gut Microbiota and Inflammation in Mice

Simple Summary Chemotherapy-related cognitive impairment (CRCI) and fatigue worsen the quality of life (QoL) of cancer patients. Multicenter studies have shown that Panax quinquefolius and vitamin C, respectively, were effective in reducing the symptoms of fatigue in treated cancer patients. We developed a behavioral C57Bl/6j mouse model to study the impact of 5-Fluorouracil (5-FU) chemotherapy on activity/fatigue, emotional reactivity and cognitive functions. We used this model to evaluate the potentially beneficial role of a Panax quinquefolius-based solution containing vitamin C (Qiseng®) or vitamin C alone in these chemotherapy side effects. We established that Qiseng® prevents the reduction in activity/exploration and symptoms of fatigue induced by 5-FU and dampens chemotherapy-induced intestinal dysbiosis and systemic inflammation. We further showed that Qiseng® decreases macrophage infiltration in the intestinal compartment, thus preventing, at least in part, the systemic elevation of IL-6 and MCP-1 and further reducing the neuroinflammation likely responsible for the fatigue induced by chemotherapy, a major advance toward improving the QoL of patients. Abstract Chemotherapy-related cognitive impairment (CRCI) and fatigue constitute common complaints among cancer patient survivors. Panax quinquefolius has been shown to be effective against fatigue in treated cancer patients. We developed a behavioral C57Bl/6j mouse model to study the role of a Panax quinquefolius-based solution containing vitamin C (Qiseng®) or vitamin C alone in activity/fatigue, emotional reactivity and cognitive functions impacted by 5-Fluorouracil (5-FU) chemotherapy. 5-FU significantly reduces the locomotor/exploration activity potentially associated with fatigue, evokes spatial cognitive impairments and leads to a decreased neurogenesis within the hippocampus (Hp). Qiseng® fully prevents the impact of chemotherapy on activity/fatigue and on neurogenesis, specifically in the ventral Hp. We observed that the chemotherapy treatment induces intestinal damage and inflammation associated with increased levels of Lactobacilli in mouse gut microbiota and increased expression of plasma pro-inflammatory cytokines, notably IL-6 and MCP-1. We demonstrated that Qiseng® prevents the 5-FU-induced increase in Lactobacilli levels and further compensates the 5-FU-induced cytokine release. Concomitantly, in the brains of 5-FU-treated mice, Qiseng® partially attenuates the IL-6 receptor gp130 expression associated with a decreased proliferation of neural stem cells in the Hp. In conclusion, Qiseng® prevents the symptoms of fatigue, reduced chemotherapy-induced neuroinflammation and altered neurogenesis, while regulating the mouse gut microbiota composition, thus protecting against intestinal and systemic inflammation.
Efficient One-Pot Synthesis of TiO2/ZrO2/SiO2 Ternary Nanocomposites Using Prunus × Yedoensis Leaf Extract for Enhanced Photocatalytic Dye Degradation

A simple, efficient, and ecofriendly method was employed to synthesize TiO2/ZrO2/SiO2 ternary nanocomposites using Prunus × yedoensis leaf extract (PYLE) that shows improved photocatalytic and antibacterial properties. The characterization of the obtained nanocomposites was done by X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, field-emission scanning electron microscopy (FE-SEM), and energy-dispersive X-ray spectroscopic (EDS) analysis. The synthesized ternary nanocomposites with nanoscale pore diameters were investigated for the elimination of Reactive Red 120 (RR120) dye. The obtained results showed about 96.2% removal of RR120 dye from aqueous solution under sunlight irradiation. Furthermore, it shows promising antibacterial activity against Staphylococcus aureus and Escherichia coli. The improved photocatalytic and antibacterial activity of TiO2/ZrO2/SiO2 may bring unique insights into the production of ternary nanocomposites and their applications in the environment and biomedical field.
Refined Lord–Shulman Theory for 1D Response of Skin Tissue under Ramp-Type Heat

In this article, we present a mathematical model of thermoelastic skin tissue based on a refined Lord–Shulman heat conduction theory. A small thickness of skin tissue is considered to be one-dimensional with mechanical clamped surfaces. In addition, the skin tissue’s outer surface is subjected to ramp-type heating while its inner surface is adiabatic. A simple Lord–Shulman theory, as well as the classical coupled thermoelasticity, are also applied in this article. Laplace transform techniques and their inversions are calculated to return to the time domain. Numerical outcomes are represented graphically to discuss the significant impacts on the temperature, dilatation, displacement, and stress distributions. Such results provide a more comprehensive and better insight for understanding the behavior of skin tissue during the temperature distribution of a specific boundary condition.
Reactive microglia are the major source of tumor necrosis factor alpha and contribute to astrocyte dysfunction and acute seizures in experimental temporal lobe epilepsy

Extensive microglia reactivity has been well described in human and experimental temporal lobe epilepsy (TLE). To date, however, it is not clear whether and based on which molecular mechanisms microglia contribute to the development and progression of focal epilepsy. Astroglial gap junction coupled networks play an important role in regulating neuronal activity and loss of interastrocytic coupling causally contributes to TLE. Here, we show in the unilateral intracortical kainate (KA) mouse model of TLE that reactive microglia are primary producers of tumor necrosis factor (TNF)α and contribute to astrocyte dysfunction and severity of status epilepticus (SE). Immunohistochemical analyses revealed pronounced and persistent microglia reactivity, which already started 4 h after KA‐induced SE. Partial depletion of microglia using a colony stimulating factor 1 receptor inhibitor prevented early astrocyte uncoupling and attenuated the severity of SE, but increased the mortality of epileptic mice following surgery. Using microglia‐specific inducible TNFα knockout mice we identified microglia as the major source of TNFα during early epileptogenesis. Importantly, microglia‐specific TNFα knockout prevented SE‐induced gap junction uncoupling in astrocytes. Continuous telemetric EEG recordings revealed that during the first 4 weeks after SE induction, microglial TNFα did not significantly contribute to spontaneous generalized seizure activity. Moreover, the absence of microglial TNFα did not affect the development of hippocampal sclerosis but attenuated gliosis. Taken together, these data implicate reactive microglia in astrocyte dysfunction and network hyperexcitability after an epileptogenic insult.
Provably-Stable Overload Ride-Through Control for Grid-Forming Inverters Using System-Wide Lyapunov Function Analysis

A key challenge associated with a grid-forming (GFM) inverter based resource (IBR) is its behavior during severe grid disturbances: since a GFM inverter regulates voltage in the fast timescale instead of current or power, it may experience a transient overload of current, power and/or energy during a severe grid disturbance. While many promising control strategies for overload ride-through have been proposed over the past two decades, transient stability of the system during and after the transition to an overload ride-through control mode remains difficult to guarantee. In this article, a novel overload ride-through control strategy is proposed for a system of grid-forming inverters that takes both self-protection and system-wide transient stability into account. A proposed system-level supervisory control uses slow communication to pre-emptively assign a set of local ride-through control parameters to individual GFM IBR, including a current-limiting virtual reactance, that guarantees that synchronism is still preserved for any set of anticipated grid disturbances. At the core of the supervisory control lies a Lyapunov-function-based routine capable of establishing a strong, albeit conservative, transient stability guarantee for the system. The proposed overload ride-through control strategy is validated via numerical integration of a reduced-order model, as well as through detailed electromagnetic transient (EMT) simulation.
An Overview of Snow Water Equivalent: Methods, Challenges, and Future Outlook

The snow depth or snow water equivalent affects water, carbon, and energy cycles as well as surface–atmosphere interactions. Therefore, the global monitoring of spatiotemporal changes in snow water equivalent is a crucial issue, which is performed by characterizing the macrophysical, microstructural, optical, and thermal characteristics of the snowpack. This paper is a review of the retrieval methods of snow water equivalent in three main categories, including in situ measurements, reconstruction approaches, and space-borne measurements, along with their basic concepts, advantages, and uncertainties. Since satellite observations are the most important tool used to detect snow properties, the paper focuses on inversion models and techniques using microwave remote sensing. The inversion models, based on various theoretical foundations, are classified into empirical, statistical, and physical (emission) models, and the techniques are described in four groups: iterative methods, lookup table, machine learning, and data assimilation approaches. At the end, the available global and regional gridded products providing the spatiotemporal maps of snow water equivalent with different resolutions are presented, as well as approaches for improving the snow data.
Dynamics and Entropy Analysis of a Frictionally Loaded Pendulum

We use friction to simultaneously damp and excite a pendulum system. A Froude pendulum attached to a suspension shaft is subjected to a frictional load. We investigate two types of response of the system: regular and chaotic responses, depending on the excitation frequency. A transient chaotic solution was also obtained. We identify the motions using phase portraits, Poincaré maps, and Fourier spectra. Finally, the composite multiscaled entropy was estimated for the specified cases to confirm the preliminary classification.
Biodegradable and highly conductive polymeric blend based on the latex of Calotropis gigantea as solid electrolyte in energy storage applications

A blend polymer based on the latex of the South-Asian giant milkweed Calotropis gigantea (CGL) combined with poly (vinylidene fluoride)-co-hexafluoropropylene (PVDF-HFP) at a mass ratio of 1:1 without the addition of doping salts was synthesized via solution casting to prepare an ionic conductive film. The morphology, crystalline state, vibrational and thermal properties of the film were investigated by Scanning electron microscopy, X-ray diffraction, Fourier Transform infrared spectroscopy (FTIR), Thermal gravimetric analysis (TGA) and Differential scanning calorimetry (DSC). The ionic conductivity and transport properties were investigated by using electrochemical impedance spectroscopy (EIS) Technique. Due the highest ionic conductivity at room temperature (2.7 x 10−2 S/cm), all-solid-state electrolyte was assembled using the prepared polymer film and a comparative study was conducted with respect to 1M H2SO4 liquid electrolyte, regarding the specific capacitance and the electrical properties. The results demonstrate that the fabricated all-solid-state supercapacitor using PVDF-HFP/CGL blend polymer film as electrolyte matches the performance of the liquid electrolyte.
Contemporary Anatomic Criteria and Clinical Outcomes With Transcatheter Mitral Repair

Background: Consensus-driven criteria have recently been proposed for prediction of mitral transcatheter edge-to-edge repair outcomes, yet validation for response to therapy is needed. We examined the relation between contemporary criteria and outcomes with mitral transcatheter edge-to-edge repair therapy. Methods: Mitral transcatheter edge-to-edge repair patients were classified according to anatomic and clinical criteria (1) Heart Valve Collaboratory criteria for nonsuitability; (2) commercial indications (suitable); and (3) neither (ie, intermediate). Analyses for Mitral Valve Academic Research Consortium–defined outcomes of reduction in mitral regurgitation and survival were performed. Results: Among 386 patients (median age, 82 years; 48% women), the most common classification was intermediate (46%), with 138 patients (36%) and 70 patients (18%) in the suitable and nonsuitable categories, respectively. Nonsuitable classification was related to prior valve surgery, smaller mitral valve area, type IIIa morphology, larger coaptation depth, and shorter posterior leaflet. Nonsuitable classification was associated with less technical success (P<0.001) and survival free of mortality, heart failure hospitalization, and mitral surgery (P<0.001). Among the nonsuitable patients, technical failure or any 30-day major adverse cardiac event occurred in 25.7%. Nevertheless, in these patients, acceptable mitral regurgitation reduction without adverse events still occurred in 69%, and their 1-year survival with mild or no symptoms was 52%. Conclusions: Contemporary classification criteria identify patients less suitable for mitral transcatheter edge-to-edge repair with respect to acute procedural success and survival, though patients most commonly fit an intermediate category. In experienced centers, sufficient mitral regurgitation reduction can be achieved safely in the selected patients even with challenging anatomy.