Miracle-dz/UniFAR-FTUs huggingface dataset:
Study of Different Features and Classifiers for Image Retrieval

With the advent of multimedia and imaging technology, lots of images sharing and uploading over the internet have been increased. It instigated development of potential image retrieval system to satisfy the requirement of mankind. The content-based image retrieval (CBIR) system retrieves the desired image by low level features similar to color, shape and texture which are not enough to explain the user’s high level perception for images. Therefore reducing this semantic gap problem of image retrieval is challenging task. Some of the concepts in image retrieval are keywords, conditions or text. Conditions are used by human to explain their information need and it also used by system as a way to stand for images. Here in this paper different types of features their advantage and disadvantages are described.
Master's Prepared Clinical Nurse Leaders

Background: Because the Clinical Nurse Leader (CNL) role is relatively new, little is known about the success of CNL graduates. Our aim was to describe the career path of CNL graduates and to measure satisfaction 2 to 10 years after graduation. Methods: A cross-sectional survey design was used to assess career trajectory and self-reported satisfaction with work, life, and educational preparation in a sample of 109 CNL graduates from one university. Online data collection was used, resulting in participants from across the United States. Results: Respondents were primarily Direct Entry CNL graduates. The majority (95%) were still working full- or part-time in nursing. Most (over 90%) were satisfied or extremely satisfied with their decision to become a nurse. Life satisfaction was high: the Satisfaction with Life Scale mean score was 24.9 (SD = 5.67). Conclusion: These results help describe CNL career trajectories and provide useful suggestions for education and practice. This information can help build the business case for the CNL.
broiler chickens , therapeutically 1 , 2

We investigated the efficacy of feed supplemented with caprylic acid (CA), a natural, 8-carbon fatty acid for reducing Salmonella enterica serovar Enteritidis colonization in commercial broiler chickens. In separate 3and 6-wk trials, 1-d-old straight-run broiler chicks (n = 70 birds/trial) were assigned to a control group (challenged with Salmonella Enteritidis, no CA) and 2 replicates of 0.7 and 1% CA (n = 14 birds/group). Water and feed were provided ad libitum. On d 1, birds were tested for any inherent Salmonella (n = 2 birds/ group). For the 3-wk trial, on d 5, birds were challenged with 8 log10 cfu of Salmonella Enteritidis of a 4-strain mixture by crop gavage, and after 5 d postchallenge, birds (n = 2 birds/group) were euthanized to ensure Salmonella Enteritidis colonization. Caprylic acid was supplemented the last 5 d before tissue collection (n = 10 birds/group). For the 6-wk trial, on d 25, birds were challenged and confirmed for Salmonella Enteritidis colonization. The birds (n = 10 birds/group) were euthanized for tissue samples after CA supplementation for the last 5 d. Caprylic acid at 0.7 or 1% decreased Salmonella Enteritidis populations in cecum, small intestine, cloaca, liver, and spleen in both 3and 6-wk trials. Body weight of birds did not differ between the groups (P ≥ 0.05). Further, to elucidate a potential antibacterial mechanism of action of CA, we investigated if CA could reduce Salmonella Enteritidis invasion of an avian epithelial cell line and expression of invasion genes hilA and hilD. The cell invasion study revealed that CA reduced invasive abilities of all Salmonella Enteritidis strains by ~80% (P < 0.05). Gene expression studies indicated that CA downregulated (P < 0.001) Salmonella invasion genes hilA and hilD. These results suggest that supplementation of CA through feed could reduce Salmonella Enteritidis colonization in broiler chicken and potentially reduces the pathogen’s ability to invade intestinal epithelial cells by downregulating key invasion genes, hilA and hilD.
University of Birmingham MyoCount

It is often desirable to characterise the morphology of myogenic cultures. To achieve this, the surface area of myotubes is often quantified, along with the nuclear fusion index (NFI). Existing methods of such quantification are time-consuming and subject to error-prone human input. We have developed MyoCount, an open-source program that runs via the freely available MATLAB Runtime and quantifies myotube surface area and NFI. MyoCount allows the user to adjust its parameters to account for differences in image quality, magnification and the colour channels used in generating the image. MyoCount measures of myotube surface area and NFI were compared to the mean of measures performed by two blinded investigators using ImageJ software (surface area R = 0.89, NFI R =0.87). For NFI, the mean coefficient of variation (CV) between two investigators (17.6 ± 2.3%) was significantly higher than that between the investigator mean and MyoCount (13.5 ± 1.4%). For measurements of myotube area, the CV did not differ between both analysis methods. Given these results and the advantages of applying the same image analysis method uniformly across all images in an experiment, we suggest that MyoCount will be a useful research tool and we publish its source code and instructions for its use alongside this article.
Using Visual Ethnography for Space Studies

A space usage study was conducted of the College of Architecture and the College of Education & Human Development on the Texas A&M University - College Station campus. This study used visual ethnography to document when and where these colleges’ undergraduate and graduate students study. The goal of the study was to use this information to inform the library in planning space usage for these student populations. This paper discusses how students use personal and public spaces in their departments, the library, and what they deem as necessities to complete their “home away from home” on-campus experience. The photos and gps database will be added to the library repository collection for future researchers to use.
DDDT_A_265167 3697..3721

1Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt; 2Department of Pharmaceutical Technology, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt Purpose: The current study aimed to discuss the potential of nanospanlastics as a surfactantbased vesicular system for improving the topical delivery of 3-acetyl-11-keto-β-boswellic acid (AKBA). AKBA is a potent anti-inflammatory drug, but it has poor oral bioavailability due to its poor aqueous solubility. Moreover, the topical delivery of AKBA is difficult due to its high lipophilicity. To overcome these drawbacks, AKBA was formulated as deformable elastic nanovesicles and nanospanlastics, for improving its topical delivery. Materials and Methods: AKBA-loaded spanlastic nanovesicles (SNVs) were formulated by ethanol injection technique according to 2 factorial design using Span 60 as a non-ionic surfactant and Tween 80 as edge activator (EA) to investigate the effect of different independent variables on entrapment efficiency (EE%), % drug released after 8 hr (Q8h) and particle size (PS) using Design-Expert software. In vitro characterization, stability test and ex vivo permeation study of the optimized formula were performed. Results: The choice of the optimized formula was based on the desirability criteria. F7 was selected as the optimized formula because it has the highest desirability value of 0.648. F7 exhibited EE% of 90.04±0.58%, Q8h of 96.87±2.67%, PS of 255.8±2.67 nm, and zeta potential of −49.56 mV. F7 appeared as spherical well-defined vesicles in both scanning electron microscope (SEM) and transmission electron microscope (TEM). The Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) studies investigated the absence of interaction between AKBA and different excipients and good encapsulation of AKBA within SNVs. F7 retained both physical and chemical stability after storage for 3 months at 4–8 °C. Ex vivo permeation test exhibited significant enhancement of permeability of F7 across rat skin than the free drug. Conclusion: Nanospanlastics could be a promising approach for improving the permeability and topical delivery of AKBA.
Microsoft BizTalk Server 2010 Unleashed

Microsoft BizTalk Server 2010 Unleashed is the 100% new, 100% practical developers guide to Microsofts most powerful version of BizTalk Server. Written by an expert team of Microsoft insiders and BizTalk MVPs, it reflects unsurpassed experience with all phases of BizTalk enterprise solutions development, from planning through deployment and administration. The authors begin by introducing BizTalk Servers architecture and key integration concepts. Next, they offer in-depth coverage of BizTalks foundational features, including schemas, maps, orchestrations, and pipelines. Youll learn how to effectively utilize both standard and custom adapters; monitor integration services; leverage cloud computing via Windows Azure; implement operational BI solutions; and make the most of business rules and BizTalks Business Rules Engine (BRE). The authors offer best practices and in the trenches tips for everything from managing deployments through implementing state-of-the-art mobile RFID solutions. No other book offers this much useful, pragmatic, and tested knowledge for successful BizTalk development. Brian Loesgen is a Principal Architect Evangelist on Microsofts Azure ISV team. A six-time Microsoft MVP, he has extensive experience in building advanced enterprise, ESB, and SOA solutions. He has coauthored eight books, including SOA with . NET and Windows Azure. Charles Young, a principal consultant at Solidsoft, and Jan Eliasen, an IT architect at Logica, have each been honored repeatedly as BizTalk MVPs, and are highly respected bloggers in the BizTalk community. Scott Colestock, chief architect for Trace Ventures, specializes in using BizTalk to implement integration and service orchestration solutions. He is a member of Microsofts Architectural Advisory Board and a BizTalk MVP. Anush Kumar, CTO of S3Edge, served as Microsofts RFID business leader and was heavily involved in designing and architecting its BizTalk RFID offerings. Jon Flanders is an independent consultant, instructor for Pluralsight, BizTalk MVP, and author of RESTful . NET. Apply BizTalk Servers sophisticated, scalable message exchange model to support virtually any business requirement Get your schemas right the first time, so you can avoid major problems downstream Use BizTalk Mapper to create maps for transforming inbound and outbound XML messages and supporting business processes Use orchestration to automate even highly-complex processes Utilize adapters and WCF to integrate any application, service, or system Extend your applications reach with Windows Azure AppFabric Capture key BizTalk infrastructure, services, and business metrics Build powerful rules-based solutions with Microsofts Business Rules Framework Establish an Enterprise Service Bus (ESB) that uses BizTalk Server as core messaging infrastructure Efficiently manage, configure, and troubleshoot BizTalk through the Administration Console Create RFID applications ranging from simple label printing to end-to-end business processes
Catechol- O -Methyltransferase and Methoxyestradiols Participate in the Intraoviductal Nongenomic Pathway Through Which Estradiol Accelerates Egg Transport in Cycling Rats 1

Estradiol (E 2 ) accelerates oviductal egg transport through intraoviductal nongenomic pathways in cyclic rats and through genomic pathways in pregnant rats. This shift in pathways, which we have provisionally designated as intracellular path shifting (IPS), is caused by mating-associated signals and represents a novel and hitherto unrecognized phenomenon. The mechanism underlying IPS is currently under investigation. Using microarray analysis, we identified several genes the expression levels of which changed in the rat oviduct within 6 hours of mating. Among these genes, the mRNA level for the enzyme catechol- O -methyltransferase (COMT), which produces methoxyestradiols from hydroxyestradiols, decreased 6-fold, as confirmed by real-time PCR. O -methylation of 2-hydroxyestra-diol was up to 4-fold higher in oviductal protein extracts from cyclic rats than from pregnant rats and was blocked by OR486, which is a selective inhibitor of COMT. The levels in the rat oviduct of mRNA and protein for cytochrome P450 isoforms 1A1 and 1B1, which form hydroxyestradiols, were detected by RT-PCR and Western blotting. We explored whether methoxyestradiols participate in the pathways involved in E 2 -acceler- ated egg transport. Intrabursal application of OR486 prevented E 2 from accelerating egg transport in cyclic rats but not in pregnant rats, whereas 2-methoxyestradiol (2ME) and 4-methoxyestradiol mimicked the effect of E 2 on egg transport in cyclic rats but not in pregnant rats. The effect of 2ME on egg transport was blocked by intrabursal administration of the protein kinase inhibitor H-89 or the antiestrogen ICI 182780, but not by actinomycin D or OR486. We conclude that in the absence of mating, COMT-mediated formation of methoxyestradiols in the oviduct is essential for the nongenomic pathway through which E 2 accelerates egg transport in the rat oviduct. Yet unidentified mating-associated signals, which act directly on oviductal cells, shut down the E 2 nongenomic signaling pathway upstream and downstream of methoxyestradiols. These findings highlight a physiological role for methoxyestradiols in the female genital tract, thereby confirming the occurrence of and providing a partial explanation for the mechanism underlying IPS.
Systems-Level Modeling of Cancer-Fibroblast Interaction The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters

Cancer cells interact with surrounding stromal fibroblasts during tumorigenesis, but the complex molecular rules that govern these interactions remain poorly understood thus hindering the development of therapeutic strategies to target cancer stroma. We have taken a mathematical approach to begin defining these rules by performing the first large-scale quantitative analysis of fibroblast effects on cancer cell proliferation across more than four hundred heterotypic cell line pairings. Systems-level modeling of this complex dataset using singular value decomposition revealed that normal tissue fibroblasts variably express at least two functionally distinct activities, one which reflects transcriptional programs associated with activated mesenchymal cells, that act either coordinately or at cross-purposes to modulate cancer cell proliferation. These findings suggest that quantitative approaches may prove useful for identifying organizational principles that govern complex heterotypic cell-cell interactions in cancer and other contexts.
Edinburgh Research Explorer When my object becomes me

Past research on the mere ownership effect has shown that when people own an object, they perceive the owned objects more favorably than the comparable non-owned objects. The present research extends this idea showing that when people own an object functional to the self, they perceive an increase in their self-efficacy. Three studies were conducted to demonstrate this new form of the mere ownership effect. In Study 1, participants reported an increase in their knowledge level by the mere ownership of reading materials (a reading package in Study 1a, and lecture notes in Study 1b). In Study 2, participants reported an increase in their resilience to sleepiness by merely owning a piece of chocolate that purportedly had sleepiness-combating function. In Study 3, participants who merely owned a flower essence that is claimed to boost creativity reported having higher creativity efficacy. The findings provided insights on how associations with objects alter one’s self-perception.
Analysis of Implementation "Jogja Istimewa" Based on Mobile Application Using UTAUT2 Model in Development Jogja Smart Province

This paper explores the Jogja Istimewa Application. This application is applied due to the development of Smart Province in the Special Region of Yogyakarta, Indonesia. Provinces with a high level of mobility require the government to be able to provide services quickly, precisely, and accurately. For this reason, researchers try to dig deeper into the extent to which the application can be accepted by the local community, both for tourists and students. Using the UTAUT2 method, are 300 questionnaires were distributed in the Special Region of Yogyakarta using a non-probability sampling technique combined using the snowball sampling method. The results show that facilitating conditions and price value are the components that have the highest impact on people's intention to use the application. Whereas behavioral intention influences on behavioral use because it has an essential role in fulfilling the behavior of the community or user to reuse the mobile-based Jogja Istimewa Application.
CAN NEUTRAL AND IONIZED POLYCYCLIC AROMATIC HYDROCARBONS BE CARRIERS OF THE ULTRAVIOLET EXTINCTION BUMP AND THE DIFFUSE INTERSTELLAR BANDS?

Up to now, no laboratory-based study has investigated polycyclic aromatic hydrocarbon (PAH) species as potential carriers of both the diffuse interstellar bands (DIBs) and the 2175 Å UV bump. We examined the proposed correlation between these two features by applying experimental and theoretical techniques on two specific medium-sized/large PAHs (dibenzorubicene C30H14 and hexabenzocoronene C42H18) in their neutral and cationic states. It was already shown that mixtures of sufficiently large, neutral PAHs can partly or even completely account for the UV bump. We investigated how the absorption bands are altered upon ionization of these molecules by interstellar UV photons. The experimental studies presented here were realized by performing matrix isolation spectroscopy with subsequent far-UV irradiation. The main effects were found to be a broadening of the absorption bands in the UV combined with slight redshifts. The position of the complete π–π* absorption structure around 217.5 nm, however, remains more or less unchanged, which could explain the observed position invariance of the interstellar bump for different lines of sight. This favors the assignment of this feature to the interstellar PAH population. As far as the DIBs are concerned, neither our investigations nor the laboratory studies carried out by other research groups support a possible connection with this class of molecules. Instead, there are reasonable arguments that neutral and singly ionized cationic PAHs cannot be held responsible for the DIBs.
INTEGRITY STRATEGIES DERIVED FROM THE PERSPECTIVE OF SUBSTANTIVE, LOGICAL AND THREE-DIMENSIONAL THINKING

A philosophy is the purpose of management. Strategy is summed up in objectives. The thesis that strategy is meaningless because it is relative has been present. Even if the strategy was relative, it may have been merely to focus on the details of the strategy. It may be unreasonable to consider the strategy meaningless simply because it is inconsistent and varying. What is most important in examining strategies is to consider what strategic objectives each company has. In the traditional analysis of strategy, classifying companies by focusing on their characteristics, and not on their business objectives, has been dominant. This causes a serious problem because it does not allow us to identify what is taking place with an overview of the strategies from the macroscopic perspective. In order to solve this problem, we selected companies for which we could obtain 2007 data from the book Mission, published about 10 years ago, which contains management philosophies and behavioral guidelines of 983 blue-chip companies in Japan, to compare them to their sales data of 2017. We analyzed the 724 companies for which the relevant data were obtainable. Of the strategic elements selected from the collection of business philosophies, we found that the most outstanding business objectives and strategic elements set forth by the high growth companies were (1) to challenge new markets and (2) to put the customer first. Although other previous studies considered important the customer satisfaction as the business objective, we did not find the companies with the emphasis on the customer satisfaction to have a high growth by two-group comparison.
Classiﬁcation Binary Trees with SSR Allelic Sizes: Combining Regression Trees with Genetic Molecular Data in Order to Characterize Genetic Diversity between Cultivars of Olea europaea L.

: During recent centuries, cultivated olive has evolved to one of the major tree crops in the Mediterranean Basin and lately expanded to America, Australia, and Asia producing an estimated global average value of over USD 18 billion. A long-term research e ﬀ ort has been established with the long-term goal to preserve biodiversity, characterize agronomic behavior, and ultimately utilize genotypes suitable for cultivation in areas of unfavorable environmental conditions. In the present study, a combination of 10 simple sequence repeat (SSR) markers with the classiﬁcation binary tree (CBT) analysis was evaluated as a method for discriminating genotypes within cultivated olive trees, while Olea europaea subsp. cuspidata was also used as an outgroup. The 10 SSR loci employed in this study, were highly polymorphic and gave reproducible ampliﬁcation patterns for all accessions analyzed. Genetic analysis indicated that the group of SSR loci employed was highly informative. A further analysis revealed that two sub populations and pairwise relatedness gave insight about synonymies. In conclusion, the CBT method which employed SSR allelic sizes proved to be a valuable tool in order to distinguish olive cultivars over the traditional unweighted pair group method with the arithmetic mean (UPGMA) algorithm. Further research which will combine phenotyping characterization of olive germplasm will have the potential to enable the utilization of existing, and breeding of new, superior cultivars.
IPS Cells and Cardiac Diseases: Challenges Versus Promises

There is a lot of excitement about the use of stem cells as a treatment for cardiovascular disease. While there is great potential for stem cells in the treatment of heart failure and myocardial infarction, using stem cells for the treatment of congenital heart disease seems much more complicated. Today, stem cells are more suitably used for disease modeling and drug discovery than treatment of congenital heart disease problems.