Miracle-dz/UniFAR-FTUs huggingface dataset:
Dual origin of room temperature sub-terahertz photoresponse in graphene field effect transistors

Graphene is considered as a promising platform for detectors of high-frequency radiation up to the terahertz (THz) range due to its superior electron mobility. Previously, it has been shown that graphene field effect transistors (FETs) exhibit room temperature broadband photoresponse to incoming THz radiation, thanks to the thermoelectric and/or plasma wave rectification. Both effects exhibit similar functional dependences on the gate voltage, and therefore, it was difficult to disentangle these contributions in previous studies. In this letter, we report on combined experimental and theoretical studies of sub-THz response in graphene field-effect transistors analyzed at different temperatures. This temperature-dependent study allowed us to reveal the role of the photo-thermoelectric effect, p-n junction rectification, and plasmonic rectification in the sub-THz photoresponse of graphene FETs.
Sun-like UXor RZ Psc

Grant M. Kennedy1, Matthew A. Kenworthy2, Joshua Pepper3, Joseph E. Rodriguez4,5, Robert J. Siverd6, Keivan G. Stassun5,7 and Mark C. Wyatt1 1Institute of Astronomy, University of Cambridge, Madingley Road, Cambridge CB3 0HA, UK 2Leiden Observatory, Leiden University, PO Box 9513, 2300 RA Leiden, The Netherlands 3Department of Physics, Lehigh University, 16 Memorial Drive East, Bethlehem, PA 18015, USA 4Harvard-Smithsonian Center for Astrophysics, 60 Garden Street MS-78, Cambridge, MA 02138, USA 5Department of Physics and Astronomy, Vanderbilt University, 6301 Stevenson Center, Nashville, TN 37235, USA 6Las Cumbres Observatory Global Telescope Network, 6740 Cortona Drive, Suite 102, Santa Barbara, CA 93117, USA 7Department of Physics, Fisk University, 1000 17th Avenue North, Nashville, TN 37208, USA
Exploring the Most Decisive Online Education Determinants as Impacted by Taiwan’s New Southbound Policy

This research cross-employed the Factor Analysis (FA) approach and the Entropy Compared Analysis (ECA) model of quantitative analysis and the fuzzy set Qualitative Comparative Analysis (fsQCA) method of qualitative analysis to creatively pioneer the most effective and efficient Comprehensive Online Education Competitive Evaluation Model (COECEM). This was done in order to conduce the most Valuable Online Education Determinants (VOED) for exploring the most decisive online education determinants of sustainable strategy in the New Southbound Policy introduced in Taiwan. The most valuable findings are that “Keyword-search Engine (KE) and Web 3.0 (W3) of core factors of Social Media Technology (SMT)” and “feedback technology function (FTF) and Course Complete Rate (CCR) of critical factors of Massive Open Online Course (MOOCs)” directly and inductively influence “Teaching Resource Distribution Administrative Consensus (TRDAC) of Resource Satisfaction Competency (RSC)”. The reason is that feedback technology function and course completion rate with keyword-search engine and Web 3.0 in online education technological supporting in taking online education courses are the most considered key factors during corporate employees selecting online education MOOCs for higher education institutes sustainable operation in support of the New Southbound Policy.
Rapid and sensitive detection of Shigella flexneri using fluorescent microspheres as label for immunochromatographic test strip.

Background Bacillary dysentery caused by Shigella genus is a major cause of morbidity and mortality worldwide. In China, the popular strain was mainly Shigella flexneri (S. flexneri). Therefore, fluorescent microspheres (FMs)-based immunochromatographic test strip (ICTS), as a novel, reliable, sensitive and uncomplicated method, was evaluated to detect S. flexneri. Methods Sixty-three clinical samples of S. flexneri were collected in this paper. Polymerase chain reaction (PCR) combined with FMs-ICTS based on magnetic purification assay was developed for the quantitative detection of Shigella. And the genus-specific gene of ipaH and drug resistant gene of CTX-M-9 from Shigella were selected to investigate the potential of this new method. The sensitivity and specificity of this method were demonstrated by classical microbiological methods (API Coryne System), PCR assay based on agarose gel electrophoresis (PCR-GE) and the real-time fluorescent quantitative PCR (RTFQ-PCR) method. Results Under optimized conditions, the lower detection limits of PCR-ICTS, PCR-GE and RTFQ-PCR were 2.5×10-7, 2.5×10-5 and the 3.2×10-7 ng/µL, respectively. Experiments demonstrated the PCR-ICTS has a diagnostic agreement of 100% with conventional PCR and RTFQ-PCR on detection of clinical samples and could correctly recognize Shigella and non-Shigella from different microbial samples. After the purification of PCR products with Silicon coated magnetic nanoparticles (Si-MNPs), the false positive results were removed because of the strong screening ability of the purification process. Our results showed that FM-based ICTS was promising for measurable and sensitive detection of S. flexneri within 3 h. Conclusions The results from immunochromatographic test were agreement with those from API Coryne system and RTFQ-PCR. Hence, this developed method might be useful for screening and monitoring clinical sample of S. flexneri, due to its speed, non-poisonous, simplicity and low-cost and helpful for promoting the prevention and control of communicable diseases caused by enteric pathogens such as S. flexneri.
Targeting aldehyde dehygrogenase 1 (ALDH1) to circumvent cisplatin resistance in NSCLC

Lung cancer is the leading cause of cancer-related mortality worldwide. Non-small cell lung cancer (NSCLC) accounts for a large proportion of cases and is typically characterized by low treatment response rates and poor overall prognosis. In the absence of specific treatable mutations, cisplatin-based chemotherapy plays an important role in the treatment of this disease. Unfortunately, the development of resistance has become a major therapeutic challenge in the use of this cytotoxic drug. Understanding the mechanisms underlying this resistance phenotype may potentially result in the development of novel agents that may enhance the sensitivity of cisplatin chemotherapy in the clinical setting. In this study, the cancer stemness phenotype of cisplatin resistant NSCLC was examined. Targeting the cancer stem cell activity of ALDH1 was investigated as a strategy to overcome chemoresistance in this cancer type. Tumors from NSCLC patients showed an increase in their profile of pluripotent stemness genes relative to matched normal lung tissues. Cisplatin exposure induced the emergence of an ALDH1-positive subpopulation in both cisplatin sensitive and resistant NSCLC cells. Treatment of resistant sublines with cisplatin chemotherapy correlated with a significant expansion of an ALDH1-positive subpopulation which further enhanced the resistance of NSCLC cells to cisplatin. Using the Aldefluor assay and FACS analysis, ALDH1positive and ALDH1-negative subpopulations were isolated and evaluated in terms of stem cell characteristics. ALDH1-positive cells exhibited important stem-like qualities in vitro, including resistance to cisplatin, increased expression of stem cell factors and asymmetric division. Targeting ALDH1 with the chemical and pharmacological inhibitors, diethylyaminobenzaldehyde (DEAB) and Disulfiram, respectively, significantly re-sensitized resistant lung cancer cells to the cytotoxic effects of cisplatin. Xenograft studies in NOD/SCID mice showed that subcutaneous injection of ALDH1-positive and ALDH1-negative cell fractions showed similar abilities to generate tumors. Our data demonstrate the existence of a putative CSC population in chemoresistant NSCLC cells and suggest a role for ALDH1 inhibition as a potential therapeutic strategy in re-sensitising chemoresistant lung cancer cells to the cytotoxic effects of cisplatin chemotherapy.
A Few Signatures Matter: Barriers to Entry in Italian Local Politics

Competition for public o ce is an essential feature of democracy, but having too many candidates competing for the same position might lead to voter confusion and become prejudicial. In current democracies, ballot access regulations limit the right to be a candidate seeking to balance this trade-o by discouraging frivolous contenders. This paper examines the causal e ect of signature requirements -a widespread ballot access regulationand nds that their impact goes beyond this goal. I use data on Italian local elections and apply a regression discontinuity design (RDD) to estimate the e ect of these requirements on electoral competition, candidates' selection and voters' participation. I nd that signature requirements reduce the number of candidates, decrease electoral competition, lead to a more experienced pool of candidates, and reduce voter turnout. The positive e ects of this policy are observed in municipalities with dispersed political power, where signature requirements lead to fewer wasted votes and fewer spoiler candidates. The downside is observed in municipalities with concentrated councils: signature requirements increase the frequency of uncontested races and reduce voters' participation. Findings show how this barrier to entry impacts on key dimensions of democracy and suggest that designing e cient electoral institutions needs a clear understanding of the local political context. JEL codes: D72, H70, C14.
Structural Alterations to the Axon Initial Segment Following Diffuse Axonal Injury as a Consequence of Age

STRUCTURAL ALTERATIONS TO THE AXON INITIAL SEGMENT FOLLOWING DIFFUSE AXONAL INJURY AS A CONSEQUENCE OF AGE By William C. Behl A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University Virginia Commonwealth University, 2014 Director: Jeffrey L. Dupree, Ph.D. Associate Professor of Anatomy and Neurobiology An epidemiological shift towards the elderly population has occurred in traumatic brain injury (TBI). Age is believed to be one of the strongest prognostic indicators following TBI. Diffuse axonal injury (DAI), a prevalent feature of TBI, is believed to be the primary cause for much of the morbidity and mortality associated with TBI. The pathobiology associated with DAI is believed to occur in response to the primary injury in a progressive, secondary fashion. Though the injury mechanisms behind DAI have been shown to occur at numerous sites along the axon, recent work suggests that the axon initial segment (AIS) may show specific vulnerability to DAI and be the primary site of axonal pathobiogenesis. Despite its established predilection for injury, the mechanisms responsible for the pathobiology remain largely unclear – particularly with regard to the age. The current study aims to shed light on the mechanisms responsible for injury by investigating structural alterations to the AIS following DAI in young and old mice. To address this question we have used a central fluid percussion injury (cFPI) model to induce mild DAI on 22-month old aged mice and 3-month old young mice at 3-hours and 24-hours survival time. Double-labeling fluorescent immunohistochemistry was used to
Antioxidant and hepatoprotective effect of pumpkin seed oil in CCl4-intoxicated rats

This study aimed to investigate the hepatoprotective and antioxidant effect of pumpkin seed oil (PSO) against Carbon tetra chloride (CCl4) induced hepatotoxicity. For this purpose, 40 male albino rats were divided into four groups. Group 1 was maintained as normal control group, were given the vehicle. Group 2 was administered with pumpkin seed oil alone at a dose of 300 mg/kg. b.w /day orally. Group 3 received CCl4 alone at a dose of 2.5 ml/kg b.w. (30%) CCl4 / corn oil intraperitoneally after 2 weeks and after 3 weeks of the experiment. Group 4 was given both 300 mg/kg. b.w. /day pumpkin seed oil for 3 weeks and 2.5 ml CCl4 as in (group 3). 48 hours after the 2nd CCl4 injection blood samples and liver tissues were collected for biochemical, histopathological and immunohistochemical examinations. In CCl4 group, ALT, AST, T. bilirubin in serum significantly increased while T. protein and albumin significantly reduced. Hepatic MDA levels increased and antioxidant enzymes (SOD & CAT) were decreased. Group 4 revealed significant decrease of the hepatic damage, ALT, AST, T. bilirubin while T. protein and albumin significantly increased. Hepatic MDA levels decreased and the efficiency of antioxidant enzymes (SOD & CAT) was improved when compared to CCl4 group. Histopatho‌logical examinations further confirmed that the PSO could protect the liver from CCl4-induced damage. Moreover, immunohistochemistry staining demonstrated that pretreatment with PSO significantly inhibited the elevation of iNOS in CCl4-treated rats. It is concluded that pumpkin seed oil has hepatoprotective and antioxidant effects.
Cell-based Therapy for Treatment of Diabetes Mellitus: Can the Agonists of Growth Hormone-releasing Hormone Make a Contribution?

C l i n M e d International Library Citation: Zhang X, Block NL, Schally AV (2016) Cell-Based Therapy for Treatment of Diabetes Mellitus: Can the Agonists of Growth Hormone-Releasing Hormone Make a Contribution? Int J Stem Cell Res Ther 3:023. doi.org/10.23937/2469-570X/1410023 Received: December 17, 2015: Accepted: February 01, 2016: Published: February 04, 2016 Copyright: © 2016 Zhang X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Zhang et al. Int J Stem Cell Res Ther 2016, 3:023
Stratospheric impact on the Northern Hemisphere winter and spring ozone interannual variability in the troposphere

Abstract. In this study we use ozone and stratospheric ozone tracer simulations from the high-resolution (0.5∘×0.5∘) Goddard Earth Observing System, Version 5 (GEOS-5), in a replay mode to study the impact of stratospheric ozone on tropospheric ozone interannual variability (IAV). We use these simulations in conjunction with ozonesonde measurements from 1990 to 2016 during the winter and spring seasons. The simulations include a stratospheric ozone tracer (StratO3) to aid in the evaluation of the impact of stratospheric ozone IAV on the IAV of tropospheric ozone at different altitudes and locations. The model is in good agreement with the observed interannual variation in tropospheric ozone, except for the post-Pinatubo period (1992–1994) over the region of North America. Ozonesonde data show a negative ozone anomaly in 1992–1994 following the Pinatubo eruption, with recovery thereafter. The simulated anomaly is only half the magnitude of that observed. Our analysis suggests that the simulated stratosphere–troposphere exchange (STE) flux deduced from the analysis might be too strong over the North American (50–70∘ N) region after the Mt. Pinatubo eruption in the early 1990s, masking the impact of lower stratospheric ozone concentration on tropospheric ozone. European ozonesonde measurements show a similar but weaker ozone depletion after the Mt. Pinatubo eruption, which is fully reproduced by the model. Analysis based on the stratospheric ozone tracer identifies differences in strength and vertical extent of stratospheric ozone impact on the tropospheric ozone interannual variation (IAV) between North America and Europe. Over North American stations, the StratO3 IAV has a significant impact on tropospheric ozone from the upper to lower troposphere and explains about 60 % and 66 % of the simulated ozone IAV at 400 hPa and ∼11 % and 34 % at 700 hPa in winter and spring, respectively. Over European stations, the influence is limited to the middle to upper troposphere and becomes much smaller at 700 hPa. The Modern-Era Retrospective analysis for Research and Applications, Version 2 (MERRA-2), assimilated fields exhibit strong longitudinal variations over Northern Hemisphere (NH) mid-high latitudes, with lower tropopause height and lower geopotential height over North America than over Europe. These variations associated with the relevant variations in the location of tropospheric jet flows are responsible for the longitudinal differences in the stratospheric ozone impact, with stronger effects over North America than over Europe.
Generating Verbal Descriptions from Medical Sensor Data: A Corpus Study on User Preferences

Understanding and interpreting medical sensor data is an essential part of pre-hospital care in medical emergencies, but requires training and previous knowledge. In this paper, we describe on-going work towards a medical decision support tool, which automatically generates textual summaries of underlying sensor data. In particular, we present results from a survey investigating the preferences of individual users and user groups when summarizing medical sensor data. We find that the users' preferences are not necessarily dependent on the user's training level, profession or gender. We therefore use cluster analysis to identify user groups with consistent preferences with regard to 4 different first aid scenarios and 3 types of physiological parameters. In future work, we will utilize these findings to automatically adapt the generated output to personal preferences.
Expanding the context of pedagogical activity to the surrounding communities

Connecting learning across school and out-of-school contexts is a growing concern in educational research and practice. In this paper, I present and discuss two pedagogical principles for expanding the context of pedagogical activity by connecting it to the students’ lives and communities. The pedagogical principles discussed in this paper are a) connecting pedagogical activity to activity systems and expert communities outside school and b) harnessing students’ productive deviations from a given pedagogical design. The argument foregrounds the distinction between the extension and expansion of the context of pedagogical activity. The context of pedagogical activity is expanded when the interaction with the outside world qualitatively changes the activity. I draw upon a sociocultural and holistic conceptualization of pedagogy that considers pedagogy as cultural intervention in human development that occurs in encounters between students’ and teachers’ activities, situated in the cultural, historical, and institutional contexts of school and beyond. In the concluding section, I discuss a sketch for a new pedagogy based on the pedagogical principles elaborated in this paper.
Insufficient Effort Responding on Mturk Surveys: Evidence-Based Quality Control for Organizational Research

This Thesis is brought to you for free and open access. It has been accepted for inclusion in Dissertations and Theses by an authorized administrator of PDXScholar. For more information, please contact pdxscholar@pdx.edu. Recommended Citation Cyr, Lee, "Insufficient Effort Responding on Mturk Surveys: Evidence-Based Quality Control for Organizational Research" (2018). Dissertations and Theses. Paper 4453.
Baseline Assessment and Prioritization Framework for Ivhm Integrity Assurance Enabling Capabilities

Fundamental to vehicle health management is the deployment of systems incorporating advanced technologies for predicting and detecting anomalous conditions in highly complex and integrated environments. Integrated structural integrity health monitoring, statistical algorithms for detection, estimation, prediction, and fusion, and diagnosis supporting adaptive control are examples of advanced technologies that present considerable verification and validation challenges. These systems necessitate interactions between physical and software-based systems that are highly networked with sensing and actuation subsystems, and incorporate technologies that are, in many respects, different from those employed in civil aviation today. A formidable barrier to deploying these advanced technologies in civil aviation is the lack of enabling verification and validation tools, methods, and technologies. The development of new verification and validation capabilities will not only enable the fielding of advanced vehicle health management systems, but will also provide new assurance capabilities for verification and validation of current generation aviation software which has been implicated in anomalous in-flight behavior. This paper describes the research focused on enabling capabilities for verification and validation underway within NASA s Integrated Vehicle Health Management project, discusses the state of the art of these capabilities, and includes a framework for prioritizing activities.
Softball Referee Quality based on Reviewed Anxiety Level

The purpose of this study is to examine the relationship with the performance of softball referees based on qualification levels. The research methods used correlational methods. The research sample was determined based on purposive sampling during softball that occurred in three championships. The data collected from the anxiety test and performance of national qualification softball A and beginner, and processed using the Kolmogorov-Smirnov Test. The results show that there is no statistically significant relationship on performance is a national qualification softball A. That is, the available qualification level has a significant relationship with operating statistics of 76.7%. Keywords—softball; anxiety level
ANTI-HELICOBACTER PYLORI ACTIVITY AND IMMUNOSTIMULATORY EFFECT OF OLIGOSACCHARIDE ISOLATED FROM AVERRHOA CARAMBOLA L.

Objective: The main goals of the study were to isolate oligosaccharide as a secondary metabolite from indigenous fruit, Averrhoa carambola L. (star fruit), and analyze its anti-Helicobacter pylori and immunostimulatory potential. Methods: The oligosaccharide (S3W) isolated using adsorption chromatography was partially characterized using tandem mass spectrometry in atmospheric pressure chemical ionization/electron spray ionization (APCI/ESI) positive and negative mode and nuclear magnetic resonance. The use of microtiter well method determined anti-H. pylori activity in the form of percentage inhibition of microbial growth, while the determination of the immunostimulatory potential of S3W implemented a protection of DNA, buccal cells, and macrophages against damage by oxidant and N-nitroso-N- methylurea (MNU) and percentage splenocyte proliferative potential. Results: S3W was a (1→2) β-heptaglucosaccharide with (4→6) α-branching at every second residue. APCI/ESI-positive mode showed B and A fragmentation patterns, while the negative mode showed abundance of A and C fragments. Anomeric hydrogen displayed integration values at 4.8 and 4.2 ppm indicating the presence of α-glucopyranose and β-glucopyranose. The compound protected DNA from oxidant-induced fragmentation. It expressed anti-H. pyloric activity with an IC50 value of 10.71 μg/ml. At 20 μg/ml, S3W protected buccal cells and macrophages significantly from damage due to oxidants and MNU carcinogens, while >50% splenocyte proliferation was induced as compared to that of an untreated control group. Conclusion: Our studies constitute the first report on the significant immunostimulatory activity of the oligosaccharide isolated from star fruit. The study, thus, supports its application as a therapeutic potential in curbing gastric diseases caused by H. pylori.