Miracle-dz/UniFAR-FTUs huggingface dataset:
Microsatellite pedigree reconstruction provides evidence that "Müller-Thurgau" is a grandson of "Pinot" and "Schiava Grossa"

‘Muller-Thurgau’ has recently been proven to be a cross between ‘Riesling’ and ‘Madeleine Royale’, a 19th century cross whose parents are unknown. Parentage analysis based on 93 grape cultivars of central Europe genotyped at 57 microsatellites provides here evidence that ‘Madeleine Royale’ = ‘Pinot’ × ‘Schiava Grossa’. Since ‘Riesling’ is known to be a progeny of ‘Gouais Blanc’, ‘Muller-Thurgau’ is therefore a grandchild of ‘Pinot’ (either ‘Pinot’ noir, gris or blanc), ‘Schiava Grossa’ (or ‘Frankenthaler’ or ‘Trollinger’) and ‘Gouais Blanc’ (or ‘Heunisch Weiss’).
TAG–glucose (TyG) index in childhood: an estimate of cut-off points and the relation to cardiometabolic risk in 4- to 9-year-old children

Abstract Objective: To propose cut-off points for the TAG–glucose (TyG) index in Brazilian children and evaluate the link to cardiometabolic risk. Design: A cross-sectional study with children from a municipality in Minas Gerais, Brazil. Anthropometric (weight, height, waist circumference and waist:height ratio), biochemical (lipid and glucose profile) and blood pressure (BP) tests were performed. Using the receiver operating characteristic curve, cut-off points for the TyG index were proposed according to sex using homoeostasis model of assessment – insulin resistance (IR) as the reference method. Setting: Viçosa, MG, Brazil. Participants: Children aged 4–9 years (n 515). Results: The TyG index cut-off points to identify the risk of IR were 7·9 and 8·1 for boys and girls, respectively. We observed that 48·7 % of the children had an increased TyG index. The increased TyG index was associated with overweight, total body and central fat, increased BP and altered lipid profile. Children with an increased TyG index had a higher accumulation of cardiometabolic risk factors. Conclusions: According to the cut-off points proposed by the current study, children at risk of IR estimated by the TyG index presented a higher cardiometabolic risk, including isolated risk factors, as to the higher accumulation of these.
The scope of empirical narratology

Abstract The article, on the “scope of empirical narratology”, offers a survey of the emerging field of empirical narratology, which arguably originates with the publication of Psychonarratology (Bortolussi and Dixon 2003). To situate empirical approaches in narratology, the article first outlines the current discussion in the field, which is divided as to whether empirical methodologies represent a un‑/helpful addition to the discipline. After that, three major methods of conducting empirical research in narratology are introduced: i. e. , a qualitative, quantitative / corpus-based, and quantitative / experimental approach. Each method is discussed and illustrated with a model study from current research. Finally, the article suggests topics for further investigation in the empirical paradigm. By presenting tenets and study models for empirical narratology, the article hopes to highlight its attractiveness for narratology at large, and to advance the developing framework.
First-principles modeling of X-ray absorption spectra enlightens the processes of scandium sequestration by iron oxides

Abstract Scandium is often associated with iron oxides in the environment. Despite the use of scandium as a geochemical tracer and the existence of world-class supergene deposits, uncertainties on speciation obscure the processes governing its sequestration and concentration. Here, we use first-principles approaches to interpret experimental K-edge X‑ray absorption near-edge structure spectra of scandium either incorporated in or adsorbed on goethite and hematite, at concentrations relevant for the environment. This modeling helps to interpret the characteristic spectral features, providing key information to determine scandium speciation when associated with iron oxides. We show that scandium is substituted into iron oxides at low concentrations without modifying the crystal structure. When scandium is adsorbed onto iron oxide surfaces, the process occurs through outer-sphere complexation with a reduction in the coordination number of the hydration shell. Considering available X‑ray absorption spectra from laterites, the present results confirm that scandium adsorption onto iron oxides is the dominant mechanism of sequestration in these geochemical conditions. This speciation explains efficient scandium recovery through mild metallurgical treatments of supergene lateritic ores. The specificities of scandium sorption mechanisms are related to the preservation of adsorbed scandium in million-years old laterites. These results demonstrate the emerging ability to precisely model fine X‑ray absorption spectral features of trace metals associated with mineral phases relevant to the environment. It opens new perspectives to accurately determine trace metals speciation from high-resolution spatially resolved X‑ray absorption near-edge structure spectroscopy in order to constrain the molecular mechanisms controlling their dynamics.
Pheromonal communication in European earwigs, forficula auricularia l. (Dermaptera: Forficulidae)

European earwigs, ForJicula auricularia L. , are thought to use an aggregation pheromone but there is controversy about its source. Hence I investigated whether each developmental stage and sex produce and respond to this pheromone and what are its components. Laboratory experiments revealed that females, males and nymphs produce and respond to an airborne aggregation pheromone. Candidate pheromone components obtained from all potential sources were analyzed by gas chromatographic-electroantennographic detection (GC-EAD) and GC-mass spectrometry. A complex synthetic blend (SB) of 30 candidate pheromone components, including benzoquinones, acids, hydroquinone, vanillin, aldehydes, ketones and an acetal significantly arrested females and nymphs in laboratory experiments. In both laboratory and field experiments, the SB lacking benzoquinones elicited significant behavioral responses from nymphs, but not from adults, suggesting that adults, unlike nymphs, use an aggregation pheromone with benzoquinones as constituent components. Additional experiments are required to determine all essential components of the earwig aggregation pheromone.
Schizophrenia-associated microRNA-148b-3p regulates COMT and PRSS16 expression by targeting the ZNF804A gene in human neuroblastoma cells

Zinc finger protein 804A (ZNF804A) has been identified by genome-wide association studies as a robust risk gene in schizophrenia, but how ZNF804A contributes to schizophrenia and its upstream regulation remains unknown. Previous studies have indicated that microRNAs (miRs) are key factors that regulate the expression levels of their target genes. The present study revealed significantly increased expression of miR-148b-3p in the peripheral blood of patients with first-onset schizophrenia compared with healthy controls, and bioinformatics analysis predicted that the ZNF804A gene is a target of miR-148b-3p. Therefore, the present study investigated the possible upstream regulation of ZNF804A by miR-148b-3p in the human neuroblastoma SH-SY5Y cell line, and assessed the implications for schizophrenia. The results revealed significantly reversed expression levels of miR-148b-3p (P=0.0051) and ZNF804A (P=0.0218) in the peripheral blood of patients with first-onset schizophrenia compared with healthy individuals. Furthermore, it was demonstrated that miR-148b-3p directly targeted ZNF804A via binding to conserved target sites in the 3′-untranslated region of ZNF804A mRNA, where it inhibited the endogenous expression of ZNF804A at both the mRNA (P=0.048) and protein levels (P=0.013) in SH-SY5Y cells. Furthermore, miR-148b-3p was revealed to regulate the expression levels of catechol-O-methyltransferase (COMT) and serine protease 16 (PRSS16) by targeting ZNF804A in SH-SY5Y cells. Collectively, the present results indicated that there was a direct upstream regulation of the schizophrenia risk gene ZNF804A by miR-148b-3p, which contributed to the regulation of the downstream genes COMT and PRSS16. Thus, the miR-148b-3p/ZNF804A/COMT/PRSS16 pathway may play an important role in the pathophysiology of schizophrenia, and may serve as a potential target in drug discovery and gene therapy for this disorder.
Personal and higher-level values of pharmacy students declaring work with patients as a preferred career path – preliminary results

Abstract Introduction and Aim. The study aims to review the premise according to which a specific set of personal values is characteristic of pharmacy students indicating work in direct contact with the patient and building a therapeutic relationship as a preferred area of professional activity. The theoretical basis for the study draws on the Schwartz model of personal values. Material and Method. The research was conducted among 211 students at the Faculty of Pharmacy, Medical University in Lublin, aged 21-30 years (M=23.17; SD=1.26). The reference group (n=83) was composed of respondents declaring preference for a professional activity implying direct contact with patients (mainly retail pharmacy). The control group included students declaring preference for a professional path not entailing direct contact with patients. The study employed the Polish version of the Schwartz Value Survey, as well as the authors’ own questionnaire pertaining to career path preference. Results. Students declaring preference for direct contacts with patients as their chosen career path, compared to respondents declaring preference for the other alternatives were more likely, as compared to the control, to express preference for the personal values of “security” and scored higher in terms of the higher-level value “conservation”. In addition, a higher preference (oscillating around statistical significance) for the personal value “benevolence” of the control group was demonstrated. Conclusions. The preference for the values revealed by pharmacy students declaring a choice of retail pharmacy gives rise to concern about the possibility of implementing a new model of pharmaceutical care in Poland.
Evaluation of the genetic structure of the breeding Common Tern (Sterna hirundo) population by means of microsatellite markers

Samples of tissues of the Common Tern (Sterna hirundo) breeding in Lithuania were collected in the colonies distributed in the basins of the River Nemunas and the River Dauguva located near Kalviai, Kietaviskės, the Nemunas delta, Lazdijai, Kretuonas, Zarasai and Ignalina. By means of 11 primer pairs designed for the analysis of microsatellite loci of taxonomically close bird species, allele frequencies at 11 polymorphic loci of the Common Tern were established. The heterozygosity ranged from 0.1809 to 0.4029 in separate colonies. No significant differences in the genetic variability of the colonies under study have been detected. However, a lower genetic variability was established for the Nemunas delta colony, which reflects a greater effect of natural selection. A high genetic differentiation was calculated for the entire population (R ST = 0.1545). Deviation from the Hardy–Weinberg equilibrium as a deficit of heterozygosity was detected in six out of the seven colonies investigated. It might be caused by a high level of inbreeding and a genetic drift. The Common Tern subpopulations breeding in the basins of the River Nemunas and the River Dauguva are genetically differentiated and form separate clades in the dendrogram obtained using the UPGMA algorithm. The obtained data allow a conclusion that the differences in the genetic structure of the Common Tern colonies are influenced by the geographic distribution of large rivers.
The Influence of Culture in Customers’ Expectations about the Hotel Service in Latin Countries with Different Human Development Levels

Abstract Due to their dynamic nature and importance in the service process definition, customers’ expectations have gained attention from researchers and practitioners, and have been essentially focused in developed countries from the Northern Hemisphere. Still, countries, regardless of the hemisphere, have different levels of socioeconomic development and cultural patterns that can have different influence on customers’ expectations about a service. In this sense, the main purpose of this research is to understand if culture equally influences customers’ expectations about a service in countries with different cultural patterns and human development levels. The multigroup analysis using structural equation modelling was used to calculate the regression weights for all the path combinations in the analysis for each proposed group of countries. About 1262 customers from 10 Latin countries were enrolled in this study to determine their expectations about the hotel service and cultural dimensions. Findings show that cultural dimensions influence customers’ expectations about the hotel service differently in groups of countries with different cultural patterns and levels of human development. Results also indicate that hotel managers should adapt the service to the level of human development of each group of countries when it comes to internationalisation.
MarQR technology for measuring relative displacements of building structure elements with regard to joints and cracks

Abstract The article presents an original optical system to measure displacements across joints or cracks in building structures. It describes the concept of system operation, algorithms to be followed and results of practical tests that have been performed. The proposed solution is based on digital photos taken with a non-metric digital camera, modified by defining its internal orientation elements and correction of lens distortion during calibration, constituting the measurement instrument registering the pictures of markers. QR (Quick Response) codes are proposed to be the markers. Being digitally processed, a set of registered images allow visualising the measured size of occurred displacements. Owing to this solution, it is possible to obtain data on a mutual position of two or more QR codes in the form of translation elements in 3D space and appropriate three orientation angles. Appointed elements are unequivocal in spatial interpretation and not limited by dimension. As the tests performed by the authors show, the results are more than satisfactory. The proposed measurement technology is an objective system of data acquisition, suitable for automating the whole monitoring process of displacements of building structure elements concerning joints and cracks.
Computed tomography scanning in the prone position for a critically hypoxic patient with COVID‐19

1Consultant Anaesthetist, 4 Consultant Radiologist, 6 Honorary Consultant Physician,Manchester University Hospital NHS Foundation Trust, Manchester, UK 2Honorary Senior Lecturer, 5 Senior Lecturer,Manchester Academic Critical Care, Division of Infection, Immunity and RespiratoryMedicine, School of Biological Sciences, Faculty of Biology,Medicine andHealth, theUniversity of Manchester, Manchester AcademicHealth ScienceCentre,Manchester, UK 3 Specialty Trainee in Anaesthesia, Health Education EnglandNorthWest, Manchester, UK 7 Senior Clinical Lecturer, LancasterMedical School, Faculty of Health andMedicine, Lancaster University, Lancaster, UK . Correspondence to: C. L. Shelton Email: cliff.shelton@nhs.net Accepted: 14May 2020
Reserves as oceanic islands: lessons for conserving some East African montane forests

Summary Current models, applying equilibrium theory to reserve planning, all treat reserves as land-bridge islands. Recent evidence suggests that most forests in East Africa, especially montane ones, are more accurately regarded as oceanic-island analogues. Differences between the biotas of the two types of island are reviewed, with particular emphasis on species turnover and niche width, and their conservation implications discussed. Proximity to nearby areas of similar habitat, to provide sources of immigrants essential to maintain the positive component of the species turnover characteristic of oceanic islands, may prove to be the most important feature of such reserves. Resume Tous les modeles classiques appliquant la theorie de l'equilibre a la conduite d'une reserve, traitent les reserves comme des ilots. Des resultats recents suggerent que la plupart des forets en Afrique de l'Est, et plus particulierement celles de montagne, sont plus judicieusement comparees a leurs analogues des iles oceaniques. Les differences entre les biomes des deux types d'isolement sont passees en revue en mettant I'accent sur le ‘turnover’ des especes et sur l'importance des niches et les implications pour leur conservation sont discutees. La proximite de zones & habitat similaire—qui fournissent des sources d'immigration essentielles au maintien des composantes positives du turnover des especes caracteristiques des iles oceaniques—pourrait s'averer l'element capital de telles reserves.
Multivariate Model for the Usage of Renewable Energies in a Rural Area

Abstract Within Hungary, the Koppányvölgye rural area was chosen due to its unique natural circumstances with its broad green nature, concerning the inhabitants’ habit for the usage and knowledge of renewable energy for residential heating. Through quota-based sampling method we collected the demographic, social and economic variables to examine their level of influence on wood for residential heating usage. We received the Likert scale values through the questionnaire, which had to be recoded for the binomial logistic regression model that we chose to use because of the indicator variable’s trait, and in aim to examine the explanatory variables’ significance. As a result, for the wood indicator variable, the age of the respondent turned out to be a significant variable, the higher age compared to lower age is a chance decreasing category for wood usage, employed compared to unemployed increased the likelihood, thereby rejected the energy ladder phenomenon, as well as more people in one household increased the chance for wood usage. The higher education, environmental awareness and insulation level of a house turned out to be non-significant for wood usage. Therefore, we strengthened those statements from the earlier studies, that in this rural region, the change of the residential heating technology is more likely to be supply driven than demand driven.
POLYETHISM IN FORAGING IN A POLYMORPHIC PREDATOR, ENOPLOGNATHA OVATA (ARANEAE: THERIDIIDAE): A CASE FOR BALANCE

Abstract Two colour morphs of Enoplognatha ovata (Clerck), “redimita” and “lineata” the abdomens of which are whitish with two pink stripes and greyish-yellow, respectively, differ in their foraging strategies. When placed in artificial arenas with flowering stems to ascend, we noted that both morphs had a strong tendency to wander over the ground rather than ascend a stem [unlike the crab spider, Misumena vatia Clerck (Araneae: Thomisidae)], but that lineata was significantly more prone to wander than was redimita. Neither morph showed choice for the type of stem or colour of flower. Nevertheless, redimita showed a greater preference for choosing white artificial flowers (discs) atop 30-cm wooden rods than did lineata. We propose that the relative abundances of the two colour morphs in the natural population represents a balanced polymorphism which is maintained in part by polyethism in hunting strategies, with redimita being more fastidious in its selection of cryptic hunting sites in flowers than is lineata, and the latter being more cryptic and more errant on the ground. Résumé Deux formes de colorations différentes d’Enoplognatha ovata (Clerck), «redimita» et «lineata», la première à l’abdomen blanc portant deux rayures roses, la seconde à l’abdomen jaune grisâtre, diffèrent aussi par leur stratégie de quête de nourriture. En présence de tiges à inflorescences pour grimper, dans des arènes artificielles, nous avons constaté que les deux formes ont fortement tendance à errer sur le sol plutôt qu’à grimper [contrairement à l’araignée crabe Misumena vatia Clerck (Araneae : Thomisidae)], et que lineata est significativement plus encline à errer que redimita. Ni l’une ni l’autre forme n’ont manifesté de préférence pour une couleur de fleur ou un type de tige en particulier. Cependant, les araignées de la forme redimita ont montré une préférence plus grande à choisir des fleurs artificielles blanches (disques) au bout de tiges de bois de 30 cm que celles de la forme lineata. Nous croyons que les abondances relatives des deux formes dans la population naturelle représentent un polymorphisme d’équilibre maintenu en partie par le polyéthisme des stratégies de chasse : redimita est un chasseur plus pointilleux dans son choix de sites de chasse dissimulés dans les fleurs, alors que la forme lineata a plus tendance à se cacher et est plus encline à errer sur le sol. [Traduit par la Rédaction]
ERBB2b mRNA isoform encodes a nuclear variant of the ERBB2 oncogene in breast cancer

The presence of nuclear ERBB2 receptor‐type tyrosine kinase is one of the causes of the resistance to membrane ERBB2‐targeted therapy in breast cancers. It has been previously reported that this nuclear location arises through at least two different mechanisms: proteolytic shedding of the extracellular domain of the full‐length receptor and translation of the messenger RNA (mRNA)‐encoding ERBB2 from internal initiation codons. Here, we report a new mechanism and function where a significant portion of nuclear ERBB2 results from the translation of the variant ERBB2 mRNA under the transcriptional control of a distal promoter that is actively used in breast cancer cells. We show that both membrane ERBB2a and nuclear ERBB2b isoforms are prevalently expressed in breast cancer cell lines and carcinoma samples. The ERBB2b isoform, which is translated from mRNA variant 2, can directly translocate into the nucleus due to the lack of the signal peptide which is required for an intermediate membrane location. Small interfering RNA‐mediated gene silencing showed that ERBB2b can repress ERBB2a expression, encoded by variant 1, whereas ERBB2a activates ERBB2b. Nuclear ERBB2 binding to its own promoter was revealed by chromatin immunoprecipitation assay. Altogether, our results provide new insights into the origin and function of nuclear ERBB2 where it can participate at the same time in a positive or a negative feedback autoregulatory loop, dependent on which of its promoters this bona fide transcription factor is acting. They also provide a new understanding for the resistance to therapies targeting the membrane‐anchored ERBB2 in breast cancer.
Tailoring Behavior Models based on Gender and Users' Exercise-Type Preference: A Social Cognitive Approach

In recent years, behavior modeling in fitness apps has become popular. However, there is little work on the implication of tailoring behavior models to their target users in fitness apps. Using the Social Cognitive Theory as a theoretical framework, we conducted a study on the efficacy of tailoring behavior models based on gender and exercise-type preference. Specifically, we investigated the social-cognitive-beliefs profile of participants when observing behavior models performing Push Up and Squat bodyweight exercises and the moderating effect of gender and exercise-type preference. Our results show that, regardless of exercise type, males’ perceived self-efficacy and projected exercise performance level are higher than females’, with males preferring Push Up and females pre-ferring Squat the most. Thus, males are more likely to engage in Push Up than females. However, there is no significant difference between both genders with respect to Squat. Our findings underscore the need for tailoring exercise behavior models based on gender and exercise-type preference. We provide design guidelines on tailoring behavior models in fitness apps to increase their effectiveness.