Miracle-dz/UniFAR-FTUs huggingface dataset:
Dual-Task Balance Training for Motor Skill Development among Children with Intelligence Quotient Discrepancy

The motor skills of people with mental disabilities are reportedly reduced compared with those of their peers. Therefore, any task incorporating both motor and cognitive skills was hypothesized to provide better motor recovery. The aim of this study is to find the effect of dual-task balance training (DTBT) on motor skill development in children of 6–13 years with intelligence quotient discrepancy (IQD) (score: 50–79). Overall, 30 individuals with mental disabilities aged 6–13 years having an IQ score of 50–79 were included. The participants were randomly divided into two groups that received dual-task training and standard balance training, respectively. IQ was measured with the Wechsler Intelligence Scale for Children-Revised, motor proficiency with the Bruininks–Oseretsky test, reaction time with COGNIBOARD, and balance with Functional Reach Test scores. Intervention was provided twice a week for 12 consecutive weeks. Participants in both groups showed higher test scores in all tests after the training program. Both training programs positively affected the motor performance of the participants. The DTBT was more effective in improving balance performance than the standard balance training. DTBT is a better tool than conventional balance training for improving motor skills and balance in children of 6–13 years with IQD (score: 50–79).
Effects of Equine-Assistant Activity on Gross Motor Coordination in Children Aged 8 to 10 Years

Generally, adequate motor coordination (MC) ability is one among the critical factors for the overall development of children. In this paper, we have thoroughly analyzed the effects of equine-assistant activity (EAA) training on MC in children. For this purpose, MC test, specifically for children, was used to the Körperkoordinationstest für Kinder (KTK), and a total of 100 children, particularly those in 8 to 10 age, were equally separated into equine-assistant activity group (EAAG) and control group (CG), respectively. The EAAG group has attended a 14-week EAA training program, while the CG joined in physical education activity once per week. The experimental results have indicated that four indices of KTK test (i.e., backward walk [WB], height jump [HH], jumping sideways [JS] and moving sideways [MS], and motor quotient [MQ] score) showed significant differences (∗P < 0.05) after a 14-week EAA training. Furthermore, the indices of physical fitness test, standing long jump (SLJ), and sit and reach (SAR) showed significant differences (∗P < 0.05), but the handgrip (HG) increased slightly without significant difference (P > 0.05) after a 14-week EAA training. In conclusion, there were improvements in MC, lower limb strength, and flexibility by EAAG for those who participated in a 14-week EAA training, and this study has demonstrated the effectiveness of the KTK assessment of MC in children 8 to 10 years.
Study of the effects of Escherichia coli lipopolysaccharide on innate immunity: The expression profile of TLR4 and CD14 genes in rat liver

Background: Bacterial endotoxin [lipopolysaccharide (LPS)] is essential for bacterial virulence as it has a biphasic effect which is either harmful and leads to aseptic shock and death or assists the body defense mechanisms as it stimulates B-cells activation. Many studies have noted that LPS do their action through activation of CD14/ TLR4 pathways, which occur mainly in liver cells, including Kupffer cells, hepatocytes, and liver sinusoidal endothelial cells, which are responsible for cytokines releases and shows the good or bad LPS effect. Aim: The current study aimed to disclose the expression changes in the profile of innate immunological receptors TLR4 and CD14 in rats’ livers after stimulation with LPS. Methods: Ten groups of male Wistar albino rats were used to study the effects of two types of LPS [extracted LPS from the local strain of Escherichia coli (ELPS) and standard E. coli (SLPS)]; these were given by using different doses (5 mg/kg and 100 μg/kg); the LPS were injected either intravenously or intraperitoneally. The TLR4 and CD14 mRNA expression patterns were estimated using qPCR after 6, 12, and 24 hours postinjection. Results: The results show that there is a negative effect of ELPS on liver CD14 and TLR4, regardless of the dose and route of administration. On the other hand, the SLPS has an upregulatory impact on the liver gene expression. Also, different times show no effect on the gene expression of the two genes. Conclusion: This study concludes that both LPS types used were able to stimulate the CD14 and TLR4 gene expression in the liver in different doses and routes of injection. Also, this study showed the possibility of using ELPS as an immunomodulator in rats.
A computer-based group discussion support tool for achieving consensus and culture change using the organisational culture assessment instrument (OCAI): an action design research study

Organisational culture change is a long and complex process that typically takes years to complete and has a very low success rate. This Action Design Research Study in an educational setting, addresses the problem by the proposed use of an Action Design Research Methodology to build and deploy an IT artifact named Organisational Culture Assessment Instrument-Spilter (OCAI-Spilter) to speed up cultural change while reducing failure rate. OCAI-Spilter should be able to fast-track culture change by addressing the problem of scalability and process losses encountered in most change projects involving large numbers of people. We deploy an iterative prototyping process using Component Base Software Development to continuously refine the tool in use. We also reviewed the design principles in Action Research Design to improve the usability of the tool. New design principles and learning were derived from this process. Finally, we showed the effectiveness of the artifact by measuring the results of the tool in use through culture surveys and alignment, as well as idea generation that was administered through the tool. Change initiatives and change projects that arise as a result of the OCAI-Spilter artifact were introduced in the organization to start and effect the journey of culture change.
THE IMPACT OF USER INVOLVEMENT ON INFORMATION SYSTEM PROJECTS

Information systems (IS) development has been studied from many perspectives. Information systems are being viewed as a service as the economy shifts from being industrial-based to service-based. This shift is motivating the business user to become more involved with the development of the system. The once clear roles of user-asspecifier and IT professional-as-developer are blurring. This research addresses three objectives. First, we survey the actual business users themselves for their perception of activities and satisfaction with the completed system. Second, we analyze the separation of business requirements into two constructs representing the functional and presentation dimensions of these requirements to advance our understanding of user involvement on information system projects. Third, we explore the combinations of user characteristics and their activities that can improve IS project performance. A new comprehensive model is proposed to represent the business user as an active participant in system development. A survey instrument is developed from a widespread literature review of IS project performance, user involvement and project management. The instrument was tested to ensure its ease of completion and its comprehensibility.
Opportunities to strengthen aging curricula across the health professions

ABSTRACT The rapidly aging population of the United States presents an urgent need for healthcare professionals trained in Gerontology, rooted in a holistic framework of health across the lifespan, and sustained by interprofessional collaborative practice. Institutions of higher education can meet this demand by aligning their curriculum and co-curriculum to train health sciences students in the increasingly important field of Gerontology. This IPEP guide will outline lessons learned at one University based on program director insight into aging-related courses, experiential training, and research opportunities. The lessons described here provide insight for other faculty and program directors on the current state of aging-related education and how to move from aging-related to aging-rich education in an interprofessional way.
Neuropsychological profile associated to PKAN in its initial phase: a case series report

ABSTRACT Pantothenase kinase-associated neurodegeneration (PKAN) is characterized by an abnormal accumulation of iron in basal ganglia and progressing varied extrapyramidal clinical symptoms. There are few studies on the cognitive symptoms and their development. The aim of this study is to explore the neuropsychological profile of PKAN patients in the initial stages of the disorder, when there are relatively fewer motor limitations. we present a full neuropsychological examination of three female cases (two early and one late onset). perception and spatial cognition were within normal range. Performance on other tasks were mixed, except for primary impairments in inhibition, flexibility, and cognitive fluency, which were consistent across cases. unlike most previous studies which report adults with major motor impairment, we present cases of young participants with minor motor difficulties. The results of the neuropsychological assessment – potentially less confounded by poor motor functioning during examination – are compatible with impairments in the fronto-subcortical circuits in the early phases of the disease. This could explain frequent misdiagnoses (e.g., with attention deficit hyperactivity disorder) in initial referrals.
Holistic Health of Two Spirit People in Canada: A Call for Nursing Action

Purpose: In response to item 7.1 from the Missing and Murdered Indigenous Women and Girls Report (2019), calling on health service providers to recognize the importance in inclusive services with and for Indigenous peoples including Two Spirit, lesbian, bisexual, transgender, queer, questioning, intersex, and asexual (2SLGBTQQIA) peoples, we undertook a review of the literature to identify the gaps in understanding and to better situate the health and resiliencies of Two Spirit people in Canada. Method: We conducted a review of 13 articles related to the health and wellness of the Canadian Two Spirit community. Overall, there was a dearth of Two Spirit specific health-related information. Results: Identified themes were grounded in the holistic Medicine Wheel teachings. These themes directly parallel holistic nursing in their demonstration that health is complex, and that there are many facets that make up an individuals’ health. Conclusion: Assessing the impact that colonization has had on the intersections of gender, race, sexuality, class, culture, and spirituality, Two Spirit people face unique health concerns. Considering the intersections of identity and structural barriers in place for this community, more research led by and in collaboration with the Two Spirit community is needed.
Bilevel Optimization Model for the Development of Real-Time Strategies to Minimize Epidemic Spreading Risk in Air Traffic Networks

An understanding is needed of how epidemics spread to new regions via the global air traffic network so that effective strategies for outbreak control can be developed. Various studies have focused on predicting epidemic spread via the complex air traffic network. However, there is a gap in the literature demanding real-time predictive models that exploit the heterogeneous nature of the air travel pattern to optimize decision making among a set of potential control strategies. A bilevel optimization model is proposed to solve the resource allocation problem for an ongoing epidemic spreading via the air traffic network. The upper-level objective is to optimize the distribution of limited resources for epidemic control, and the lower-level simulation model computes the risk posed to the network under possible scenarios. Results from a demonstration network highlight the advantages of this model. A case study evaluates the risk posed by Ebola to the United States through the domestic air traffic network. The results demonstrate the ability of the model to develop real-time strategies that account for the heterogeneous nature of the air traffic network and the complex dynamics of epidemic spread.
Prognostic Significance of Controlling Nutritional Status Score (CONUT) in Patients Undergoing Pericardiocentesis.

Background Malnutrition is associated with a poor prognosis in cardiovascular diseases, however the prognostic impact of the Controlling Nutritional Status (CONUT) score in patients with pericardial effusion (PE) is not known. Methods This was a retrospective study conducted among 301 consecutive patients with PE who underwent pericardiocentesis. CONUT score was calculated from serum albumin level, total cholesterol level and lymphocyte count. The prognostic role of admission CONUT score on long-term mortality was evaluated. Results The patients were divided into two groups according to long-term mortality. A total of 131 patients died during follow-up. In multivariable regression analysis, chronic heart failure [hazard ratio (HR): 3.21, 95% confidence interval (CI): 1.18-8.70, p < 0.01], malignancy (HR: 5.67, 95% CI: 3.34-9.63, p < 0.01) and CONUT score (HR: 1.21, 95% CI: 1.10-1.33, p < 0.01) were found to be independent predictors of long-term mortality. CONUT score was significantly higher in the patients who died (5.8 ± 2.4 vs. 3.6 ± 2.2, p < 0.01). In receiver operating characteristics analysis, a CONUT score ≥ 4.5 predicted long-term mortality with 66% sensitivity and 69% specificity (area under curve: 0.73, 95% CI: 0.67-0.79, p < 0.01). Conclusions In patients with PE, CONUT score is an independent prognostic factor for mortality.
2-Methoxyestradiol combined with ascorbic acid facilitates the apoptosis of chronic myeloid leukemia cells via the microRNA-223/Fms-like tyrosine kinase 3/phosphatidylinositol-3 kinase/protein kinase B axis

ABSTRACT Chronic myeloid leukemia (CML) is a malignant myeloproliferative tumor. 2-Methoxyestradiol (2-ME) is an endogenous estrogen metabolite that shows efficacy in human malignancies. Ascorbic acid (AA) possesses antioxidant activity. This study explored the mechanism of 2-ME combined with AA in the apoptosis of CML cells. Firstly, human CML cell lines were treated with 2-ME and AA. The cell viability, apoptosis, reactive oxygen species (ROS), and mitochondrial membrane potential (MMP) were detected. miR-223 expression in CML cells was detected. In addition, CML cells were transfected with miR-223 inhibitor. The binding relationship between miR-223 and FLT3 was verified. Subsequently, the FLT3 was overexpressed or silenced for the function rescue experiment to confirm the role of FLT3 in CML cell apoptosis. The expression levels of key factors of the PI3K/AKT pathway were detected. Finally, xenograft nude mouse models were established for in vivo verification. 2-ME + AA treatment inhibited CML cell viability and promoted apoptosis, elevated ROS content, and reduced MMP. 2-ME + AA treatment promoted miR-223 expression in CML cells. miR-223 targeted FLT3. Moreover, miR-223 inhibitor or FLT3 overexpression partially annulled the effect of 2-ME + AA on CML cells. 2-ME + AA inhibited the PI3K/AKT pathway via the miR-223/FLT3 axis. Furthermore, 2-ME + AA suppressed CML xenograft growth in mice. Collectively, 2-ME + AA promoted miR-223 expression and suppressed FLT3 and the PI3K/AKT pathway, thereby facilitating the apoptosis of CML cells and inhibiting CML xenograft growth in mice. Graphical abstract
Identification of Prognostic Biomarkers in Papillary Thyroid Cancer and Developing Non-Invasive Diagnostic Models Through Integrated Bioinformatics Analysis.

BACKGROUND Papillary thyroid cancer (PTC) is the most frequent subtype of thyroid carcinoma, mainly detected in patients with benign thyroid nodules (BTN). Due to the invasiveness of accurate diagnostic tests, there is a need to discover applicable biomarkers for PTC. So, in this study, we aimed to identify the genes associated with prognosis in PTC. Besides, we performed a machine learning tool to develop a non-invasive diagnostic approach for PTC. METHODS For the study's purposes, the miRNA dataset GSE130512 was downloaded from the GEO database and then analyzed to identify the common differentially expressed miRNAs in patients with non-metastatic PTC (nm-PTC)/metastatic PTC (m-PTC) compared with BTNs. The SVM was also applied to differentiate patients with PTC from those patients with BTN using the common DEMs. A protein-protein interaction network was also constructed based on the targets of the common DEMs. Next, functional analysis was performed, the hub genes were determined, and survival analysis was then executed. RESULTS A total of three common miRNAs were found to be differentially expressed among patients with nm-PTC/m-PTC compared with BTNs. In addition, it was established that the autophagosome maturation, ciliary basal body-plasma membrane docking, antigen processing as ubiquitination & proteasome degradation, and class I MHC mediated antigen processing & presentation are associated with the pathogenesis of PTC. Furthermore, it was illustrated that RPS6KB1, CCNT1, SP1, and CHD4 might serve as new potential biomarkers for PTC prognosis. CONCLUSIONS RPS6KB1, CCNT1, SP1, and CHD4 may be considered as new potential biomarkers used for prognostic aims in PTC. However, performing validation tests is inevitable in the future.
A cytosolic disulfide bridge‐supported dimerization is crucial for stability and cellular distribution of Coxsackievirus B3 protein 3A

RNA viruses in the Picornaviridae family express a large 250 kDa viral polyprotein that is processed by virus‐encoded proteinases into mature functional proteins with specific functions for virus replication. One of these proteins is the highly conserved enteroviral transmembrane protein 3A that assists in reorganizing cellular membranes associated with the Golgi apparatus. Here, we studied the molecular properties of the Coxsackievirus B3 (CVB3) protein 3A with regard to its dimerization and its functional stability. By applying mutational analysis and biochemical characterization, we demonstrate that protein 3A forms DTT‐sensitive disulfide‐linked dimers via a conserved cytosolic cysteine residue at position 38 (Cys38). Homodimerization of CVB3 protein 3A via Cys38 leads to profound stabilization of the protein, whereas a C38A mutation promotes a rapid proteasome‐dependent elimination of its monomeric form. The lysosomotropic agent chloroquine (CQ) exerted only minor stabilizing effects on the 3A monomer but resulted in enrichment of the homodimer. Our experimental data demonstrate that disulfide linkages via a highly conserved Cys‐residue in enteroviral protein 3A have an important role in the dimerization of this viral protein, thereby preserving its stability and functional integrity.
A Statistical Model for Wind Power on the Basis of Ramp Analysis

Abstract Due to stochastic nature of wind distribution, wind power output comes with unscheduled changes called ramp events. In this paper, a semi-analytical approach is considered to analyze the distribution of ramp events. A simple empirical equation is derived based on the probability of wind ramp events considering the stochastic nature of wind power distribution for the Indian state of Karnataka. The proposed functional relationship shows a satisfactory approximation of the actual distribution of ramp events and helps to estimate the statistical behaviour of wind output in terms of frequency of ramp events for pre-defined threshold power outputs.
Fault detection, classification and location for transmission lines and distribution systems: a review on the methods

A comprehensive review on the methods used for fault detection, classification and location in transmission lines and distribution systems is presented in this study. Though the three topics are highly correlated, the authors try to discuss them separately, so that one may have a more logical and comprehensive understanding of the concepts without getting confused. Great significance is also attached to the feature extraction process, without which the majority of the methods may not be implemented properly. Fault detection techniques are discussed on the basis of feature extraction. After the overall concepts and general ideas are presented, representative works as well as new progress in the techniques are covered and discussed in detail. One may find the content of this study helpful as a detailed literature review or a practical technical guidance.
Functional Transcriptomic Studies of Immune Responses and Endotoxin Tolerance in Early Human Sepsis

ABSTRACT Background: Limited studies have functionally evaluated the heterogeneity in early ex vivo immune responses during sepsis. Our aim was to characterize early sepsis ex vivo functional immune response heterogeneity by studying whole blood endotoxin responses and derive a transcriptional metric of ex vivo endotoxin response. Methods: Blood collected within 24 h of hospital presentation from 40 septic patients was divided into two fractions and incubated with media (unstimulated) or endotoxin. Supernatants and cells were isolated, and responses measured using: supernatant cytokines, lung endothelial permeability after supernatant exposure, and RNA expression. A transcriptomic signature was derived in unstimulated cells to predict the ex vivo endotoxin response. The signature was tested in a separate cohort of 191 septic patients to evaluate for association with clinical outcome. Plasma biomarkers were quantified to measure in vivo host inflammation. Results: Ex vivo response to endotoxin varied and was unrelated to immunosuppression, white blood cell count, or the causative pathogen. Thirty-five percent of patients demonstrated a minimal response to endotoxin, suggesting early immunosuppression. High ex vivo cytokine production by stimulated blood cells correlated with increased in vitro pulmonary endothelial cell permeability and was associated with attenuated in vivo host inflammation. A four-gene signature of endotoxin response detectable without the need for a functional assay was identified. When tested in a separate cohort of septic patients, its expression was inversely associated with hospital mortality. Conclusions: An attenuated ex vivo endotoxin response in early sepsis is associated with greater host in vivo inflammation and a worse clinical outcome.
Photovoltaic Energy Source for Street Lighting in Hebron/ Palestine Using GSM Technology

This projectpresents a new approach of a street lighting system that usesa photovoltaic produced energy controlled by a GSM (Global System for Mobile Communication). The casestudy was conducted in an openarea of Al-Hesbah Street in Hebron. This system is based on installinga light fixtures supplied with 24V DC loaded by photovoltaic energy. Long life rechargeable batteries are used to provide energy back -up by means of photovoltaic panels. The GSM system p rovides a light control for turning the light on or off according to the environmental illumination level via computers. Laboratory tests have shown that this system can produce a massive amount of energy savings for the Palestinian community in Hebron; he nce it is very promising and compromising solution.