Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparisons of segregating populations for genetic mapping

The advent of molecular marker techniques allowed the construction of high informative genetic linkage maps for several vegetal species. Maximum likelihood has come into use for genetic mapping for estimation of several parameters, including the average information content (A.I.C.) and variance V ) r ( ∧ of the recombination values "r". Our study presents the A.I.C. and V ) r ( ∧ of various population types as additional criteria for the choice of the mapping population, since they define accuracy and tru stworthiness of the estimated recombination frequencies. The populations with the most accurate recombination estimates are the F 2 population mapped with codominant markers and the RIL (recombinant inbred lines) populations for low recombination values. The employment of the A.I.C. and variance V ) r ( ∧ of the recombination values may contribute to the quality of the molecular data and be an indicator for the cases where more robust analyses are necessary.
Dissecting the factors controlling seed development in the model legume Medicago truncatula

Legumes are not only indispensible for sustainable agriculture but are also a rich source of protein in food and feed for humans and animals, respectively. However, major proteins stored in legume seeds are poor in sulfur-containing amino acids, and may be accompanied by anti-nutritional factors causing low protein digestibility problems. In this regard, Medicago truncatula serves as a model legume to study legume seed development especially the phase of seed storage protein accumulation. As developing legume seeds are complex structures, a thorough knowledge of the morphogenesis of the seed and the characterization of regulatory mechanisms underlying the embryo development and seed filling of legumes is essential. Mutant studies have identified a DOF1147 (DNA-binding with One Finger) transcription factor belonging to the Zn-Finger family which was expressed in the endosperm at the transition period between embryogenesis and seed filling phase. During my PhD work, a number of transgene constructs were successfully generated for expression analysis of DOF1147 gene as well as the DOF1147 protein. A successful transformation protocol was also established for stable genetic transformation of M. truncatula. Subcellular localization studies have demonstrated that DOF1147 is a nuclear protein. A phylogenetic tree revealed different groups of DOF transcription factors with conserved domains in their protein sequence. In silico promoter analysis of putative target genes of DOF1147 identified cis-regulatory elements of various transcription factors along with auxin responsive elements (AuxREs) suggesting a possible role of auxin during seed development. A study of in vitro seed development under different hormone regimes has demonstrated the positive effect of auxin on kinetics of seed development in terms of gain in seed fresh weight and size, with NAA having a stronger effect than IBA. Using the cytomic approach, we further demonstrated the effect of auxin on the onset of endoreduplication in such seeds, which is the cytogenetic imprint of the transition between the cell division phase and the accumulation of storage products phase during seed development. As a whole, this work highlighted that the auxin treatments modulate the transition between mitotic cycles and endocycles in M. truncatula developing seeds by favouring sustained cell divisions while simultaneously prolonging endoreduplication.
Robust Non-Orthogonal Multiple Access for Aerial and Ground Users

In this paper, we consider a downlink wireless communication system with the co-existence of ground user (GU) and mobile aerial user (AU). Existing solutions rely on orthogonal multiple access (OMA) to support these users, however, OMA is unable to provide the best rate and outage performance because its spectral efficiency is limited by the users’ channel conditions and rate requirements. Thus, we propose an aerial-ground non-orthogonal multiple access (AG-NOMA) scheme that pairs the GU and AU for data and control links, respectively. Unlike terrestrial non-orthgonal multiple access (NOMA), the key idea of AG-NOMA is to exploit the asymmetric features of the channels and rate demands of the GU and AU in the downlink communication. Based on these opportunities, we investigate the maximum achievable GU rate over a time-varying wireless channel while satisfying the AU Quality-of-Service (QoS) requirement with perfect and partial channel state information (CSI). For perfect CSI, we derive the optimal successive interference cancellation (SIC) policy, power allocation, GU rate, and feasibility conditions in closed-form expressions. For partial CSI, we also derive the suboptimal SIC policy and power allocation in closed-form expressions, and further discussed a tradeoff between the achievable rate and reliability. This tradeoff depends on the system parameters, and thus we have suggested some appropriate parameters based on theoretical support and standard requirements to strike a balance between rate and reliability. Our simulation results show that AG-NOMA scheme with perfect and partial CSI can achieve up to +99% GU rate-improvement as compared to OMA and provide a more sustainable rate-improvement and/or lower outage probability than terrestrial NOMA scheme.
Appropriateness of Overridden Alerts in Computerized Physician Order Entry: Systematic Review

Background The clinical decision support system (CDSS) has become an indispensable tool for reducing medication errors and adverse drug events. However, numerous studies have reported that CDSS alerts are often overridden. The increase in override rates has raised questions about the appropriateness of CDSS application along with concerns about patient safety and quality of care. Objective The aim of this study was to conduct a systematic review to examine the override rate, the reasons for the alert override at the time of prescribing, and evaluate the appropriateness of overrides. Methods We searched electronic databases, including Google Scholar, PubMed, Embase, Scopus, and Web of Science, without language restrictions between January 1, 2000 and March 31, 2019. Two authors independently extracted data and crosschecked the extraction to avoid errors. The quality of the included studies was examined following Cochrane guidelines. Results We included 23 articles in our systematic review. The range of average override alerts was 46.2%-96.2%. An average of 29.4%-100% of the overrides alerts were classified as appropriate, and the rate of appropriateness varied according to the alert type (drug-allergy interaction 63.4%-100%, drug-drug interaction 0%-95%, dose 43.9%-88.8%, geriatric 14.3%-57%, renal 27%-87.5%). The interrater reliability for the assessment of override alerts appropriateness was excellent (kappa=0.79-0.97). The most common reasons given for the override were “will monitor” and “patients have tolerated before. ” Conclusions The findings of our study show that alert override rates are high, and certain categories of overrides such as drug-drug interaction, renal, and geriatric were classified as inappropriate. Nevertheless, large proportions of drug duplication, drug-allergy, and formulary alerts were appropriate, suggesting that these groups of alerts can be primary targets to revise and update the system for reducing alert fatigue. Future efforts should also focus on optimizing alert types, providing clear information, and explaining the rationale of the alert so that essential alerts are not inappropriately overridden.
Impact of Cypermethrin and Ekalux on respiratory and some biochemical activities of a fresh water fish, Tilapia mossambica.

The effects of pyrethroid insecticide, cypermethrin and Ekalux on the rate of oxygen consumption and some biochemical parameters of the fish, Tilapia mossambica were investigated under sublethal toxicity. Median lethal concentration (LC50) of cypermethrin and Ekalux to the fish for 24 hour exposure was determined during bioassay study. The rate of oxygen consumption of the fish was studied under sulethal concentration of Cypermetrin and Ekalux. It showed significantly decreased oxygen uptake. Biochemical parameters protein, glucose, cholesterol and triglyceride were analysed in the blood of fish and all the parameters showed significant changes. The protein contents were found to be declined in all the samples analysed during all the exposure periods. Hyperglycemic condition recorded may be due to the stress induced by pesticide as physiology of organism with the help of corticosteroids. Hypocholesteremia level noted in the study may be due to utilization of fatty deposits instead of glucose for energy purpose. The declining trend observed in triglycerides level may be due to the increase in the breakdown of lipids. The experimental results depict that both cypermethrin and Ekalux are toxic to the fish Tilapia mossambica.
Bioinformatic analysis indicates a relationship between CpG islands & nuclear protein function, as well as a Stop Codon Usage Bias

CpG islands (CGI) are associated with gene regulation with unknown mechanism of expression, though it has been over 20 years since their initial identification. This study was conducted to grasp the importance of CGIs and their distribution in human chromosome 1, and from this to further characterise how they relate to gene expression in the human genome. Analysing the distribution of CGIs and core promoter regulatory elements in promoter region of the genes on human chromosome 1 contributes a greater understanding of the types of genes with which CGIs are associated. The trends in protein localisation and function with the variation of CpG island density in the genes on human chromosome 1 suggest that genes with a CpG island in the promoter region significantly more frequently produce proteins that are located in the cytoplasm, nucleus, and nucleolus, and less frequently in the plasma membrane. As well as this, it is indicated high density CpG islands are more frequently related to genes with protein products localised significantly more in the nucleus and with likely DNA binding function. The relationship between CpG islands and core promoter elements in human chromosome 1 support a relationship between CpG islands and the GC box that may have transcriptional significance for the function of CpG islands.
FOLLOW THE MONEY: INSIDER TRADING AND PERFORMANCE OF HEDGE FUND ACTIVISM TARGETS

Hedge fund activism announcements are associated with positive market reactions, and they introduce information asymmetry between insiders and outside investors. Target firm insiders have superior information about the campaign and play an important role in the campaign negotiation. This study examines insiders’ behavior as information asymmetry rises following the campaign announcement. Insiders increase trading in their own firms in response to the campaign announcement. These post-announcement insider trades have additional return predictability than insider trades in other times. Post-announcement insider buys predict higher probabilities of achieving successful campaign outcomes including management turnovers, increases in payout, and corporate restructurings, and higher value of these outcomes. I also find evidence that insiders use campaign resistance and trading interactively to achieve higher wealth gain.
Improving crop resistance to abiotic stress

Preface Foreword (G. S. Khush) Foreword (H. Hirt) Genetic modification of crops: Past, present and future (N. V. Fedoroff) Omics techniques in crop research: An overview (B. Fakrudin, R. Tuberosa and R. K Varshney) Translational biology approaches to improve abiotic stress tolerance in crops (R. Iannacone, F. Cellini, G. Morelli and I.Ruberti) Functional genomics of drought tolerance in crops: Engineering transcriptional regulators and pathways (B. Rathinasabapathi) Transcriptomic and metabolomic approaches to the analysis of plant freezing tolerance and cold acclimation (D. K. Hincha, C. Espinoza and E. Zuther) Molecular breeding for enhancing abiotic stress tolerance using halophytes (A. Parida, S. George and K. Kavita) Helicases in improving abiotic stress tolerance in crop plants (N. Tuteja, S. S. Gill and R. Tuteja) Cotton: genetic improvement for drought stress tolerance - current status and research needs (E. AbouKheir, M. S. Sheshshayee, T. G. Prasad and M. Udayakumar) Wheat: Functional genomics of abiotic stress tolerance (P. Khurana, H. Chauhan and N. Khurana) Rice: Genomics-assisted breeding for drought tolerance (P. Vikram, A. Kumar, A. Singh and N. K. Singh) Maize: Physiological and molecular approaches for improving drought tolerance (I. Singh, T. Nepolean, R. A. Rajendran and M. Shono) Barley: Omics approaches for abiotic stress tolerance (N. Pecchioni, J. A. Milc, M. Pasquariello and E. Francia) Sugarcane: Physiological and molecular approaches for improving abiotic stress tolerance and sustaining crop productivity (A. K.Shrivastava and S. Srivastava) Sunflower: Improving crop productivity and abiotic stress tolerance (C. A. Sala, M. Bulos, E. Altieri and M. L. Ramos) Sorghum: Improvement of abiotic stress tolerance (M. Dalal*, M. Karthikeyan and V. Chinnusamy) Brassica crop species: Improving water use efficiency - challenges and opportunities ( C. D. Palmer, W. Keller, J. Singh and R. Datla) Generation and Scavenging of Reactive Oxygen Species in Plants under Stress (Sarvajeet Singh Gill, Lamabam Peter Singh, Ritu Gill, and Narendra Tuteja) Understanding the 'Commoneome? Operative in Plants in Response to Various Abiotic Stresses (Hemant R Kushwaha, Sneh L Singla-Pareek, Sudhir K Sopory, and Ashwani Pareek)
Mesonephric adenocarcinoma treated with paclitaxel-carboplatin adjuvant chemotherapy: a case report

A 52-year-old G2P2A0 post-menopausal woman with no significant past medical history was referred to this institution for evaluation of an exophytic nodule in the uterus that measured about 1.3 centimeters on ultrasonography. The mass was discovered incidentally when she visited her healthcare provider for gynecologic checkup. She did not have any symptoms but ultrasonography was performed as an annual health checkup. The result of the Pap smear performed at the same time did not show any abnormal findings. At the initial discovery of the lesion, the patient was scheduled to be followed up after six months under the impression of uterine leiomyoma. The follow-up ultrasonography showed that the size of the mass increased to 4.1×3.4 centimeters and it was seen with mixed echogenicity with hypervascularity (Figure 1A). The patient was scheduled to be followed up in another three months. When she revisited, the transvaginal ultrasonography revealed atrophic uterus with a 5.8×4.4-centimeter inhomogenous mass lesion with hypervascularity in the right wall with an irregular border (Figure 1B). The endometrium measured 4.0 millimeters while the moderate amount of fluid collection in the posterior cul-de-sac was noted. No significant increases in tumor markers including alpha-fetoprotein (AFP, 1.6 IU/mL), carcinoembryonic antigen (CEA, 0.4 ng/mL), cancer antigen 125 (CA 125, 10.2 U/mL) or cancer antigen 19-9 (CA 19-9, 7.0 U/mL) were observed. Given the rapid growth of the lesion with hypervascularity surrounding the mass, the patient underwent a singleport access laparoscopic mass removal under the presumed diagnosis of rapid growing uterine leiomyoma. The patient did not undergo CT or MRI because the authors usually do not perform such imaging scans for leiomyomas. Despite that the patient did not have any symptoms preoperatively, at surgery, a round ruptured mass about 6 centimeters in diameter was noted in the right lateral side of the uterus with severe adhesions with adjacent adnexal structures (Figures 2A–B). The mass was removed and sent for frozen section, which could not exclude uterine leiomyosarcoma. Therefore, total laparoscopic hysterectomy with bilateral salpingo-oophorectomy were performed. Cytological examinations of peritoneal washing fluid were also performed but did not reveal any evidence of malignancy. On gross examination, the removed mass from the uterus measured 8.0×6.0 centimeters. The cut surface showed whitish to tanned with focal necrotic le-
ThermoPixels: Toolkit for Personalizing Arousal-based Interfaces through Hybrid Crafting

Much research has shown the potential of affective interfaces for reflection on, and understanding of bodily responses. Yet, people find it difficult to engage with, and understand their biodata which they have limited prior experience with. Building on affective interfaces and material-centered design, we developed ThermoPixels, a toolkit including thermochromic and heating materials, as well as galvanic skin response sensors for creating representations of physiological arousal. Within 10 workshops, 20 users with no expertise in biosensors or thermochromic materials created personalized representations of physiological arousal and its real-time changes using the toolkit. We report on participants' material exploration, their experience of creating shapes and the use of colors for emotional awareness and regulation. We discuss embodied exploration and creative expression, the value of technology in emotion regulation and its social context, and the importance of understanding material limitations for affective sense-making.
A Comprehensive Analysis On Intrusion Detection In Iot Based Smart Environments Using Machine Learning Approaches

— With the expansion in the quantity of Internet-connected devices, security and privacy concerns were the important obstructions hindering the extensive adoption of the IoT. Security in IoT has become a major consideration for all, including the organizations, consumers, and the government. While attacks on any system can't be completely secured perpetually, real-time detection of the attacks are significant to protect the systems in a compelling way. Privacy and security are the major important concerns in the domain of real-time communication and predominantly on IoTs. With the development of IoT, the security of network layer has drawn better focus. The vulnerabilities of security in the IoT can create security threats dependent on any application. In this manner there is a basic prerequisite for security development and enhancement for the IoT system for preventing security attacks dependent on vulnerabilities of security. In this study we reviewed IoT system, security attacks, security requirements and its applications based on Machine learning approaches. The goal of this review was to analyze the Machine learning techniques that could be utilized to develop and enhance the security techniques for IoT systems.
Recruitment Process and Recruitment Outcomes: An Empirical Study of Business Organizations of Pakistan

Organizations need highly skilled, qualified and professionally-matured employees to achieve the desired performance. The role of effective human resource management systems is important in creating a mature business culture and a highly systematic recruitment process can yield productive and talented employees. This research has investigated the mediating relationship between recruitment process, teamwork and organizational performance in business organizations through the lens of social exchange theory (SET) and resource-based view (RBV). A quantitative positivist paradigm approach was used in this research study. Data was collected through a questionnaire from 282 industrial units in Pakistan. Hypotheses were tested in the light of mediating model. The data was analyzed by using Structural Equation Modeling (SEM) to find out the effect of the independent variable (recruitment process) on the depended variable (organizational performance) through mediating variable (teamwork). Results show that recruitment process has a positive impact on teamwork and organizational performance. Teamwork has a significant and positive effect on organizational performance. The study provides a sound theoretical contribution to the literature with respect to the recruitment process and organizational performance relationship in business organizations of Pakistan. Exploration of next generation recruitment strategies are important to develop great people and great performance.
Mixing Time Estimation in Reversible Markov Chains from a Single Sample Path

This article provides the first procedure for computing a fully data-dependent interval that traps the mixing time $t_{\text{mix}}$ of a finite reversible ergodic Markov chain at a prescribed confidence level. The interval is computed from a single finite-length sample path from the Markov chain, and does not require the knowledge of any parameters of the chain. This stands in contrast to previous approaches, which either only provide point estimates, or require a reset mechanism, or additional prior knowledge. The interval is constructed around the relaxation time $t_{\text{relax}}$, which is strongly related to the mixing time, and the width of the interval converges to zero roughly at a $\sqrt{n}$ rate, where $n$ is the length of the sample path. Upper and lower bounds are given on the number of samples required to achieve constant-factor multiplicative accuracy. The lower bounds indicate that, unless further restrictions are placed on the chain, no procedure can achieve this accuracy level before seeing each state at least $\Omega(t_{\text{relax}})$ times on the average. Finally, future directions of research are identified.
Occurrence of Bacillus cereus and Bacillus licheniformisstrains in the course of UHT milk production

Transfer of Bacillus cereus and Bacillus licheniformis strains from milk into final products (UHT milk) was studied. Phase milk samples were collected during the whole time of milk processing (one milk batch) in collaboration with the dairy. Representative B. cereus and B. licheniformis strains were characterised and compared by ribotyping with EcoRI enzyme and a probe complementary to Escherichia coli 16S and 23S rRNA as well as by phenotyping. According to 26 phenotypical traits the B. licheniformis strains formed almost a homogeneous group. In contrast, B. cereus strains exhibited variable results in several tests. The hybridisation profiles divided the analysed strains into two groups in full accordance with their species classification. Band patterns of B. cereus strains showed similarities ranging from 77 to 97%; this similar- ity values correlated with biochemical test results as well. B. licheniformis strains exhibited band pattern similarities from 82 to 100%. The hybridisation profiles of B. licheniformis strains B79 (pasteurized milk) were absolutely identical (100% similarity). Their phenotypical test results were identical as well. These results imply the identity of the strains isolated in the course of UHT milk production.
Supporting Developers' Coordination in the IDE

Teamwork in software engineering is time-consuming and problematic. In this paper, we explore how to better support developers' collaboration in teamwork, focusing on the software implementation phase happening in the integrated development environment (IDE). Conducting a qualitative investigation, we learn that developers' teamwork needs mostly regard coordination, rather than concurrent work on the same (sub)task, and that developers successfully deal with scenarios considered problematic in literature, but they have problems dealing with breaking changes made by peers on the same project. We derive implications and recommendations. Based on one of the latter, we analyze the current IDE support for receiving code changes, finding that historical information is neither visible nor easily accessible. Consequently, we devise and qualitatively evaluate Bellevue, the design of an IDE extension to make received changes always visible and code history accessible in the editor.