Miracle-dz/UniFAR-FTUs huggingface dataset:
PII: S1010-7940(01)00705-9

Objective: To understand differences in the sub-diaphragmatic venous physiology between patients with fenestrated and non-fenestrated total-cavopulmonary connections (TCPC). Methods: We studied the effects of respiration, retrograde ̄ow, and gravity on the sub-diaphragmatic venous ̄ows in 20 normal healthy volunteers (control), 25 Fontan patients with non-fenestrated TCPC, and 21 with fenestrated TCPC. Subhepatic inferior vena cava (IVC), hepatic vein (HV), and portal vein (PV) ̄ow rates were measured with Doppler ultrasonography during inspiration and expiration in both supine and upright positions. The supine inspiratory-to-expiratory ̄ow rate ratio was calculated to re ̄ect the effect of respiration, the supine-to-upright ̄ow rate ratio was calculated to assess the effect of gravity, and the magnitude of retrograde ̄ow was evaluated with respect to total antegrade ̄ow. Mean IVC, HV, and wedged hepatic venous (WHV) pressures were measured during cardiac catheterization in four TCPC patients before and after fenestration closure. The transhepatic venous pressure gradient (TVPG) was calculated as the difference between the HV and WHV pressure. Results: Compared with control, HV ̄ow in TCPC was heavily dependent on respiration; this inspiratory capacity was greater in fenestrated than non-fenestrated subjects (inspiratory-to-expiratory ̄ow ratio 1.7, 4.4, and 3.0, respectively P , 0:001). Normal retrograde HV ̄ow was diminished in TCPC patients, furthermore, fenestrated subjects had less ̄ow reversal than non-fenestrated (retrograde as percent of antegrade ̄ow 43, 19, and 30%, respectively P , 0:001). Gravity decreased IVC and HV ̄ows more in TCPC subjects than control, but this effect was not different between the two TCPC groups. Closure of the fenestration resulted in higher IVC and HV pressures (pre-closure versus post-closure pressures [mmHg]: 11.2 ^ 4.0 vs. 12.3 ^ 3.9, and 11.5 ^ 3.8 vs. 12.4 ^ 3.8, respectively P # 0:001). The normal TVPG was reduced in fenestrated TCPC, and worsened after fenestration closure (0.9 ^ 0.3 and 0.7 ^ 0.4, respectively P , 0:04). Conclusions: Fenestration of the inferior venous connection has important in ̄uences on subdiaphragmatic venous return in TCPC patients. Although fenestration lowers venous pressures and partially restores TVPG, its bene®cial effects on ̄ow in TCPC patients are mediated primarily by an increase in inspiration-derived forward HV ̄ow and reduced ̄ow reversal. These observations suggest fenestration results in a more ef®cient and less congested splanchnic circulation in TCPC patients, and may have important implications in the early and late management of Fontan patients. q 2001 Elsevier Science B.V. All rights reserved.
Identifying ex ante characteristics of Radical Inventions through patent-based indicators

With this study we aim at contributing to a better measurement of the ex ante technological dimensions characterizing Radical Inventions. Integrating insights from the existing economics and management literature, we characterize radical inventions ex ante along two dimensions: New Functionality and New Origins. New Functionality regards the extent to which an invention provides substantially new functional capacities. New Origins reflects the extent to which an invention builds on different technological knowledge and principles compared to common practice. These can include technological as well as scientific origins. For each dimension we propose an operationalization using patent classification and citation information. We use a large sample of patent applications to present a first validation exercise. Results indicate that although both dimensions are correlated, each of the indicators proposed convey different information on the ex ante characteristics of Radical Inventions
Analysis of Methodologies for Hiding Sensitive Frequent Itemsets using Border Based Approach

: Data mining is a technique that blends traditional data analysis methods with modern sophisticated algorithms for processing large amount of data. However, misuse of this technique may lead to disclosure of sensitive information. Privacy preserving data mining is the new effort in the screening of sensitive information. Association rule hiding methodologies aim at sanitising the original database in a way that now rule can be mined from the original database. This paper contains a survey of various sensitive information hiding methodologies.
Running head: Randomized controlled trial of a parenting program in South Africa

Parenting programs in high-income countries have been shown to reduce the risk of child maltreatment. However, there is limited evidence of their effectiveness in low- and middle-income countries. The objective of this study was to examine the initial effects of a parenting program in reducing the risk of child maltreatment in Cape Town, South Africa. Low-income parents ( N = 68) with children aged three to eight years were randomly allocated to either a group-based parenting program or a wait-list control group. Assessments were taken at baseline and at immediate post-test after the intervention was delivered. Primary outcomes were parent-report and observational assessments of harsh parenting, positive parenting, and child behavior problems. Secondary outcomes were parent-report assessments of parental depression, parenting stress, and social support. Results indicated moderate treatment effects for increased frequency of parent-report of positive parenting and observational assessments of child-led play. There were also potentially clinically relevant though non-significant treatment effects for reduced frequency of reported child behaviour problems, increased frequency of reported perceived social support, and reduced frequency of observed negative parenting. Observational assessments also found moderate treatment effects for less frequent positive child behavior and clinically relevant though non-significant effects of more frequent negative child behaviour. Results suggest preliminary intervention effectiveness in reducing the risk of child maltreatment by improving positive parenting behavior in highly vulnerable families in low-resource communities. Further development is required to strengthen program components regarding child behavior management. Future research would benefit from a larger trial with sufficient power to determine program effectiveness.
Institutional Knowledge at Singapore Management University Institutional Knowledge at Singapore Management University Regret Aversion in Reason-based Choice Regret Aversion in Reason-based Choice

This research examines the moderating role of regret aversion in reason-based choice. Earlier research has shown that regret aversion and reason-based choice effects are linked through a common emphasis on decision justification, and that a simple manipulation of regret salience can eliminate the decoy effect, a well-known reason-based choice effect. We show here that the effect of regret salience varies in theory-relevant ways from one reason-based choice effect to another. For effects such as the select/reject and decoy effect, both of which were independently judged to be unreasonable bases for deciding, regret salience eliminated the effect. For the most-important attribute effect that is judged to be normatively acceptable, however, regret salience amplified the effect. Anticipated self-blame regret and perceived decision justifiability consistently predicted preferences and thus offer a parsimonious account of both attenuation and amplification of these reason-based choice effects.
Aeroacoustics of Cavity Flow using Time-Resolved Particle Image Velocimetry

The flow past open cavities is a problem that is encountered in many engineering applications and can result in intense acoustic tones. The flow physics and acoustics of cavity configurations are complex and both computational and experimental techniques are being developed to provide an opportunity to gain further understanding and provide a tool to predict not only cavity tone frequencies but their amplitude. In this thesis, noise produced due to low subsonic flow around a rectangular cavity has been studied by ‘visualising’ the flow around it. The flow visualisation was done by an experimental technique called Time-Resolved Particle Image Velocimetry (TR-PIV) which allowed us to measure velocity field around the cavity with high spatial and temporal resolution. The pressure fields were then obtained from the velocity fields by a technique called Planar Pressue Imaging(PPI). The sound emitted by the cavity flow was obtained from the pressure data by implementing Curle’s acoustic analogy. The pressure computed from PPI and acoustic pressure computed from the acoustic analogy were compared with the measurements from microphones located on the cavity surface and in the acoustic-field respectively. The acoustic feedback was identified to be the dominant flow mechanism. The spectrum of acoustic pressure obtained from Curle’s Analogy and Microphone measurements showed presence of peaks corresponding to Rossiter mode 2 as well as harmonics of it. Although, there was an underestimation of sound pressure level, especially at the tonal peaks, Curle’s analogy was able to capture the location of these tonal peaks and trend in broadband frequencies. It is concluded that Particle Image Velocimetry has the potential to develop into a powerful tool for aeroacoustic measurements. It is recommended that better processing tool be developed to estimate the velocities and pressure near the walls which are affected by reflections. Further study of cavity flow should be be done using Tomographic PIV to account for three dimensionality of cavity flow. Advanced digital signal processing algorithms must be used to study the acoustic data. MSc. Thesis D.Parkhi
CTL Primed by Exogenous Antigens + CD8Antigenic Epitopes Regulate the Phenotype of

We previously reported that insulin-speciﬁc, MHC class I-restricted CTL precursors can be primed by injecting C57BL/6 mice with bovine insulin in CFA. These bovine insulin-primed CTL displayed a type 0 CTL phenotype, producing IL-4, IL-5, IL-10, low levels of IFN- g , but no TNF- a . By contrast, CTL generated from C57BL/6 mice primed with OVA in CFA produced IFN- g and TNF- a but no IL-4, IL-5, or IL-10 and therefore were classiﬁed as type 1 CTL. Although CD4 1 T cell subsets have been compared extensively in the literature, CTL subsets are less well characterized. Here, the phenotype, function, and requirements for the in vivo activation of type 1 and type 0 CTL cells were studied. Although both types of CTL express many of the same cell-surface Ags, OVA-speciﬁc CTL but not bovine insulin-primed CTL expressed CT-1, a carbohydrate epitope of CD45, and bovine insulin-primed CTL but not OVA-speciﬁc CTL expressed Fas constitutively. Priming of CTL was abrogated by depletion of phagocytic cells but not CD4 1 T cells, whereas depletion of CD4 1 T cells but not phagocytic cells inhibited Ab responses in the same mice. Neither endogenous IL-4 nor the dose of priming Ag altered the CTL phenotypes, but the antigenic peptides of OVA and bovine insulin were key to determining the differentiation of either type 1 or type 0 CTL. To our knowledge, this is the ﬁrst time that antigenic epitopes have been demonstrated to inﬂuence the phenotype of Ag-speciﬁc CTL responses. These results may be relevant to the development of peptide vaccines in which a particular type of CTL response is desired. The Journal of Immunology, 2000, 164: 5698–5703.
THE GENETIC FIDELITY ASSESSMENT OF AILANTHUS EXCELSA’S LEAVES BETWEEN MANDSAUR (M.P.) AND RATLAM (M.P.) DISTRICTS

The Ailanthus excelsa Roxb. is found in different states in India and their leaves are used as fodder for cattle. 95% ethanolic extract was shown as good solvent having a much extraction capacity of secondary metabolites from dried leaves. The glycosides, phenol, lignin, saponins and tannins were present in the 95% ethanolic extract of dried leaves. The concentrations of DNA were found 0.0218, 0.0210, 0.0207, 0.0215 and 0.0212 mg/100gm respectively and their mean value was found 0.0212 mg/100 gm in Mandsaur area of Madhya Pradesh where as in the area of Ratlam, the DNA concentrations were found 0.0218, 0.0212, 0.0218, 0.0218 and 0.0223mg/100gm respectively and the mean value was 0.0218 mg/100 gm. The comparative study between Mandsaur (M.P.) area and Ratlam (M.P.) area were calculated by ANOVA-CRD in which the S.EM. value was 0.006289 and CD 5% 0.018553. These datas showed a significant value.
Deep Learning and Knowledge Integration for Music Audio Analysis (Dagstuhl Seminar 22082)

Given the increasing amount of digital music, the development of computational tools that allow users to find, organize, analyze, and interact with music has become central to the research field known as Music Information Retrieval (MIR). As in general multimedia processing, many of the recent advances in MIR have been driven by techniques based on deep learning (DL). There is a growing trend to relax problem-specific modeling constraints from MIR systems and instead apply relatively generic DL-based approaches that rely on large quantities of data. In the Dagstuhl Seminar 22082, we critically examined this trend, discussing the strengths and weaknesses of these approaches using music as a challenging application domain. We mainly focused on music analysis tasks applied to audio representations (rather than symbolic music representations) to give the seminar cohesion. In this context, we systematically explored how musical knowledge can be integrated into or relaxed from computational pipelines. We then discussed how this choice could affect the explainability of models or the vulnerability to data biases and confounding factors. Furthermore, besides explainability and generalization, we also addressed efficiency, ethical and educational aspects considering traditional model-based and recent data-driven methods. In this report, we give an overview of the various contributions and results of the seminar. We start with an executive summary describing the main topics, goals, and group activities. Then, we give an overview of the participants’ stimulus talks and subsequent discussions (listed alphabetically by the main contributor’s last name) and summarize further activities, including group discussions and music sessions
Macroscopic Balance Equations for Spatial or Temporal Scales of Porous Media Hydrodynamic Modeling

We focus on the first author’s previous work addressing macroscopic balance equations developed for different spatial and temporal scales. We elaborate on previous findings so as to orient the reader to fundamental concepts with which the mathematical formulations are developed. The macroscopic balance Partial Differential Equations (PDE’s) are obtained from their microscopic counterparts by volume averaging over a Representative Elementary Volume (REV), considering a non-Brownian motion. The macroscopic quantity of phase/ component intensive quantities product, is the premise of two concurrent decomposed macroscopic balance PDE’s of the corresponding extensive quantity. These are concurrently valid at the primary REV order of length and at a significantly smaller secondary length. The hydrodynamic characteristic at the smaller spatial scale was found to always be described by pure hyperbolic PDE’s, the solution of which presents displacement of sharp fronts. Reported field observations of condensed colloidal parcels motion, validate the suggestion of hyperbolic PDE’s describing fluid momentum and components mass balance at the smaller spatial scale. Controlled experiments supplemented by numerical predication can yield the hydrodynamic interrelation between the two adjacent spatial scales. Further, we focus on the first author past developments concerning dominant macroscopic balance PDE’s of a phase mass and momentum and a component mass following an onset of abrupt pressure change. These account for the primary REV order of length and for evolving temporal scales. Numerical simulations were found to be consistent in excellent agreement with experimental observations. During the second time increment and in view of the aforementioned developments, we presently elaborate on new findings addressing theoretically the efficiency of expansion wave for extracting solute from a saturated matrix. Simulations comparing between pumping using an approximate analytical form based on Darcy’s equation and numerical prediction addressing the emitting of an expansion wave, suggest that the latter extracts by far more solute mass for a spectrum of different porous media. and component macroscopic balance for the smaller spatial scale.
Metabolism of oral-turinabol by human steroid hormone-synthesizing cytochromes P450 •

The human mitochondrial cytochromes P450 CYP11A1, CYP11B1 and CYP11B2 are involved in the biosynthesis of steroid hormones. CYP11A1 catalyzes the side-chain cleavage of cholesterol and CYP11B1 and CYP11B2 catalyze the final steps in the biosynthesis of gluco- and mineralocorticoids, respectively. This study reveals their additional capability to metabolize the xenobiotic steroid oral-turinabol (OT), which is a common doping agent. By contrast, microsomal steroid hydroxylases did not convert OT. Spectroscopic binding assays revealed dissociation constants of 17.7 µM and 5.4 µM for CYP11B1 and CYP11B2, respectively, while no observable binding spectra emerged for CYP11A1. Catalytic efficiencies of OT conversion were determined to be 46 min -1 mM -1 for CYP11A1, 741 min -1 mM -1 for CYP11B1 and 3338 min 1 mM -1 for CYP11B2, which is in the same order of magnitude as for the natural substrates, but shows a preference of CYP11B2 for OT conversion. Products of OT metabolism by the CYP11B subfamily members were produced at mg-scale with a recombinant Escherichia coli -based whole-cell system. They could be identified by NMR to be 11 β -OH-OT for both CYP11B isoforms, whereby CYP11B2 additionally formed 11 β ,18-diOH-OT and 11 β -OH-OT-18-al, which rearranges to its tautomeric form 11 β ,18-expoxy-18-OH-OT. CYP11A1 produces six metabolites, which are proposed to include 2-OH-OT, 16-OH-OT and 2,16-diOH-OT based on LC-MS/MS analyses. All three enzymes are shown to be inhibited by OT in their natural function. The extent of inhibition thereby depends on the affinity of the enzyme for OT and the strongest impact was demonstrated for CYP11B2. These findings suggest that steroidogenic cytochromes P450 can contribute to drug metabolism and should be considered in drug design and toxicity studies.
Reader Response: Long-term Effect of Regular Physical Activity and Exercise Habits in Patients With Early Parkinson Disease

PPMI database analysis by Dr. Tsukita et al. reports the effects of physical activity on the progression of Parkinson disease (PD) clinical parameters, measured using the Physical Activity Scale for the Elderly (PASE). It confirms previous studies showing that regular exercise is associated with improved outcomes.2 Although the study uses rigorous statistical methods, the reported association between maintained physical activity and concurrent slower deterioration of postural and gait stability should be interpreted carefully.
An observational determination of the evolution of planetary nebulae

For a sample of 23 Galactic planetary nebulae, selected on the basis of distance certainty and temperature of the central stars being below T < 70; 000 K, central star Zanstra luminosities are determined. This has been done by obtaining magnitudes, interstellar extinctions and Zanstra temperatures. The magnitudes are determined from CCD images taken through a narrow band Hr -lter centered at a wavelength 6648A and transposing the uxes found towards the visual. The extinctions are found by at the same time obtaining images taken through a H -lter centered at 6566A. The ratio of the resulting nebular line H -uxes and 6cm or 21cm radio ux densities gives the extinction. The extinctions can be deduced from catalogued H=H -ratios and the Galactic dust map of Schlegel et al. (1998) as well. The Zanstra temperatures are obtained from the ratio of the ionizing and the visual photons emitted by the star, F (H )(6566)=Fvis(5450). For this method to work it is assumed that the central star radiates as a blackbody and the optical depth of the hydrogen ionizing radiation is greater than unity. The positions of the central stars along with their ages are plotted in a Hertzsprung-Russelldiagram for each of the four methods used to determine the extinction. The ages are determined by dividing the radii of the planetary nebulae with their expansion velocities. Then this observational determination of the evolution of planetary nebulae is compared to the the
Simulation numérique d'écoulements multi-fluides sur grille de calcul

Cette these porte sur le developpement de methodes numeriques pour le calcul d'ecoulements incompressibles multi-fluides sur grille de calcul, s'inscrivant ainsi dans le cadre du projet MecaGrid.Une etude de la grille MecaGrid met en evidence son caractere heterogene et ses consequences. Plusieurs techniques d'optimisation sont presentees afin d'ameliorer son utilisation : repartir la masse de calcul de facon adaptee, et privilegier le travail des processeurs vis-a-vis des communications reseaux penalisantes.Des methodes numeriques sur maillage non structure compose de tetraedres sont choisies pour realiser la simulation directe d'ecoulements multi-fluides avec capture d'interface. Nous adoptons une approche unique qui rappelle celle du Multiscale, dans laquelle la condensation d'une fonction Bulle pyramidale est utilisee comme technique universelle de stabilisation.Les equations de Navier-Stokes incompressible sont resolues par une methode elements finis mixtes a interpolation P1+/P1. Un schema temporel d'Euler implicite est applique, en association avec un algorithme de Newton pour lineariser le probleme.Les interfaces sont capturees par une technique Level Set a interpolation continue P1 qui consiste a resoudre une equation de transport stabilisee par la condensation d'une Bulle (Residual-Free Bubbles). Le couplage avec une equation d'Hamilton-Jacobi permet de reinitialiser la fonction Level Set au court de son transport. La comparaison avec une methode Galerkin discontinue proche du Volume of Fluid montre que le Level Set se distingue par sa simplicite et l'absence de diffusion numerique.Enfin, les simulations numeriques sont validees par plusieurs cas test reconnus.
Molecular Detection of Carbapenem Resistant Klebsiella pneumoniae in Intensive Care Units

Carbapenem Resistant Klebsiella pneumoniae carrying bla KPC, bla NDM-1 and bla OXA-48 genes are difficult to treat. This study was conducted to study the genotypic features of carbapenem resistance in isolates of Klebsiella pneumoniae isolated from Intensive care units from a tertiary care Hospital. Klebsiella pneumoniae (n=89) isolates resistant to at least one carbapenem were collected from 377 patients for 24 months. Carbapenem resistance was determined via VITEK-2 system and confirmed my Modified Hodge test. Genes were analyzed using Polymerase chain reaction (PCR). The rate of resistance by Vitek-2 system for carbapenems was 23.6% and Modified Hodge test against ertapenem was 83% for 89 CRKP isolates. There were 39%, 29% and 46% of isolates positive for bla KPC, bla NDM-1 and bla OXA-48 genes respectively. The presence of all three genes showed 8.9% positivity. The molecular classification of carbapenemases will be useful for the betterment of patients with concurrent carbapenem resistant Enterobacteriaceae (CRE) infections. This could prevent outbreaks and complications in Intensive care units.