Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of H. Pylori and Sex on Leukocyte Differentials

Background: Influence of Helicobacter pylori infection and sex difference on leukocyte differentials was insufficiently understood. We therefore conducted the current study to evaluate influence of H. pylori and sex on peripheral leukocyte differentials as well as influence of Helicobacter pylori eradication. Methods: Dyspeptic patients and persons asked to examine gastroduodenal lesions at medical check were included. Total leukocytes, differentials, and anti-H.pylori IgG antibody were measured. Those change after eradication was also measured. H. pylori infection was assessed by anti-H. pylori IgG antibody, rapid urease test, and pathologic findings. H. pylori-uninfected patients and non-dyspeptic/seronegative persons were regarded as negative controls. Results: Totally 374 patients and 299 controls were evaluated, and 167 patients were successfully eradicated. Peripheral counts of neutrophil and monocyte elevated with H. pylori infection: 3221.7+/-1108.7 vs. 2911.9+/-1027.3/μL and 307.5+/-130.5 vs. 281.5+/-106.4/μL, (p­=.0002 and .0054). Compared to females, males manifested elevated counts of every leukocyte, but the difference was insignificant in basophil (p=.0089, 0.0316, <.0001, and .0384 for neutrophil, lymphocyte, monocyte, and eosinophil, respectively). After eradication, counts of neutrophil, lymphocyte, and monocyte declined: 3111.0+/-966.8 to 2785.1+/997.2/μL, 1905.9+/-603.2 to 1831.6+/-613.5/μL, and 293.1+/-113.3 to 264.3+/-93.6/μL by 2 months (p=<.0001, .0189, and .0004). In contrast, eosinophil counts elevated from 123.2+/-97.0 to 139.8+/-115.4 by 2 months, and to 159.6+/-132.8/μL by 6 months (p=.0349 and <.0001). Conclusions: We confirmed increases in neutrophils and monocytes in H. pylori-infected patients. Successful eradication reduced peripheral counts of neutrophil, lymphocyte, and monocyte, whereas it increased eosinophil counts. Males manifested elevated counts of every leukocyte, comparing to females. H. pylori infection influences systemic immune response and may not predispose to allergic disorders.Trial registration: The study protocol was registered on UMIN (University hospital Medical Information Network system) in Japan (R000017345) in 2014.
Hydrolysis of Microcrystalline Cellulose to Produce Fermentable Monosaccharides by Plasma Acid

ABSTRACT Plasma acid was obtained by treating distilled water with a dielectric barrier discharge (DBD) at atmospheric pressure. The tentative relationship between discharge conditions and pH value of the plasma acid was investigated. In order to optimize the hydrolysis conditions of microcrystalline cellulose with the plasma acid, an orthogonal experiment was carried out and the colorimetric determination of 3,5-dinitro-salicylic acid was applied to measure the concentration of total reduced sugar (TRS). The results showed that the pH value of the plasma acid was related to the discharge time. The acidity of the plasma acid was maintained for several hours and then faded gradually. The microcrystalline cellulose was hydrolyzed effectively by the plasma acid and the optimal hydrolysis conditions were as follows: pH 1.42 of the plasma acid, hydrolysis temperature of 80°C and hydrolysis time of 60 min. Under these conditions, the microcrystalline cellulose with polymerization degree of 200–300 was hydrolyzed completely to produce monosaccharides, including xylose and glucose with the mole ratio of 1:35, as shown by high-performance liquid chromatography (HPLC) analysis. Moreover, the hydrolysis of luffa cellulose with polymerization degree of 500–600 was also carried out. The luffa cellulose was hydrolyzed completely to produce monosaccharides including xylose, mannose and glucose with mole ratio of 6.7:1:218. Therefore, it could be concluded that the main hydrolysis product of both types of cellulose was glucose. The glucose yield of microcrystalline cellulose was 46%, whereas for luffa cellulose it was 41%. This method was an environmentally friendly and effective method to hydrolyze cellulose.
SARS-CoV-2 and the Secret of the Furin Site

The SARS-CoV-2 high infectivity is due to the functional polybasic furin cleavage site in the S protein. How it was acquired is unknown. There are two challenges to face: (i) an evolutionary model, to fit the origin of the coronavirus; and (ii) a molecular mechanism for the site acquisition. Here we show genomic fingerprints which are specific of Pangolin-CoVs, Bat-SARS-like (CoVZC45, CoVZXC21), bat RatG13 and human SARS-CoV-2 coronaviruses. This, along with phylogenetic analysis, we found that these species have the same evolutionary origin in the bat, including a genetic recombination of S gene between Pangolin-CoV (2017) and RatG13 ancestors. However, this does not explain why SARS-CoV-2 is the only of them with the furin site, which consists in four amino acid (PRRA) motif. The Arginine doublet is encoded by CGGCGG codons. Surprisingly, none of the Arginine doublet of other furin site of viral proteins from several type of viruses, are encoded by the CGGCGG codons. This makes it difficult to consider a virus recombination as mechanism for the PRRA acquisition. The origin of SARS-CoV-2, is the origin of the recognition cleavage site. The bat coronavirus RaTG13 appears to be the closest relative of the SARS-CoV-2, but was isolated in 2013. So, new RatG13 samples would provide insights into the acquisition of the polybasic motif.
Analysis of Renal Platinum Content as a Novel Approach to Protect against Cisplatin Nephrotoxicity: A Review

Cisplatin (cis-diamine-dichloroplatinum (II), CDDP) is a prominent member of the effective broadspectrum antitumor drugs. However, its clinical usage is restricted due to serious side effects particularly nephrotoxicity. The vulnerability of the kidney to CDDP is almost certainly related to its primary role in the excretion of the drug as intact CDDP and its platinum containing products are excreted mainly in the urine. There is a correlation between the level of platinum in urine and nephrotoxicity because of renal uptake of the drug. Some analytical methods were applied for the determination of platinum content in biological fluids such as plasma, urine, serum, and peritoneal fluid. Studies have not documented a strong correlation between the renoprotective mechanism and the diminution of renal platinum content.
Long-term baseline ozone changes in the Western US: A synthesis of analyses

ABSTRACT Quantification of the magnitude and long-term changes in ozone concentrations transported into the U.S. is important for effective air quality policy development. We synthesize multiple published trend analyses of western U.S. baseline ozone, and show that all results are consistent with an overall, non-linear change – a rapid increase (~5 ppb/decade) during the 1980s that slowed in the 1990s, maximized in the mid-2000s, and was followed by a slow decrease (~1 ppb/decade) thereafter. This non-linear change accounts for ~2/3 of the variance in 28 published linear trend analyses; we attribute the other 1/3 of the variance to unquantified autocorrelation in the analyzed data sets that result primarily from meteorologically driven interannual ozone variability. Recent systematic changes in baseline ozone on the U.S. West Coast have been relatively small – the standard deviation of the 2-year means over the 1990–2017 period is 1.5 ppb. International efforts to reduce anthropogenic precursor emissions from all northern mid-latitude sources could possibly reduce baseline ozone concentrations, thereby improving U.S. ozone air quality. Implications: Ozone is an air pollutant with significant human and ecological health impacts. Air masses transported into the western U.S. from over the Pacific Ocean carry ozone concentrations that are, on average, a large fraction of the U.S. health standard. The US EPA policy assessment conducted for the recent review of the ozone National Ambient Air Quality Standard (NAAQS) found that 2016 regional average MDA8 ozone concentrations in the western US maximized in summer at ~52 ppb and that ~40 ppb of that maximum was contributed by ozone of natural and transported anthropogenic contributions. Thus, quantifying these trans-boundary background ozone concentrations has been identified as an important issue for a complete understanding of US air quality. Published analyses of temporal trends of these transported ozone concentrations vary widely, from early reports of increases to more recent reports of decreases. We show that the long-term ozone changes are nonlinear, with substantial concentration increases (as large as ~5 ppb/decade) before the mid-2000s when a maximum is reached, followed by a small decrease of ~1 ppb/decade thereafter. Superimposed on the overall changes is significant interannual variability that makes accurate determination of systematic trends over decade-scale time periods uncertain. The end of the previously increasing trends, and the recent decrease in transported ozone concentrations, is a good news for U.S. air quality, as it eases the difficulty of achieving the ozone air quality standard.
An efficient method for the preparation of 2,2,4-trisubstituted 1,2-dihydroquinolines using catalytic amount Bi(OTf)3 as catalyst

Substituted 1,2-dihydroquinolines have been synthesised from substituted anilines and methyl pyruvate using catalytic amounts of commercially available Bi(OTf)3 as a catalyst under microwave-assisted conditions. This method is simple, easy to work up, inexpensive, with a broad substrate scope and short reaction times. The reaction provides 1,2-dihydroquinolines (19 examples) in good yields (34-97% yields).
From National Policy to Individual Practice: A Critical Discourse Analysis on Three Levels

Enlightened by critical discourse analysis (CDA) perspective and intertextuality analysis, this article puts forward Institutional logic-Cognition-Discourse-Practice Approach as a framework for the study of connection and transformation process involved in multi-level-subjects’ policy discourse, and explains how national policy be implemented across multiple levels. To do this, a case analysis of the agricultural entrepreneurship in Guangdong Province was conducted. Policy discourse from three levels were collected as analysis data. By probing the traces of previous text in subsequent text, this article explains how intertextuality is formed across three levels of subjects.
A Note on the Energy Structure Theory and Development for 2D Viscoelasticity

ABSRACT--The basis of the Energy Structure Theory can be introduced in references [1-5] presented in 2020. Energy Structure Theory explains some new thermo-physical concepts including energy space, energy structure equation, dependent and independent energy components, irreversibility components, irreversibility structure, etc. Since this theory is presented considering the first and second laws of thermodynamics as well as energy components of the system as the basis of the energy structure equation, this theory can be expanded for a variety of the scientific applications. For example, in this note, we will try to introduce some of these scientific applications in general physics and engineering analysis. Also, using relevant concepts, 2D viscoelasticity problems will be studied. Also, the viscoelasticity and kinematic energy will be calculated for 2D viscoelasticity problems. Energy structure theory let us to study physical processes from the perspective of the componential energy exchange as well as independent and dependent energy component concept introduced by this theory.
Parameterizing Nonpropagating Form Drag over Rough Bathymetry

Slowly evolving stratified flow over rough topography is subject to substantial drag due to internal motions, but often numerical simulations are carried out at resolutions where this “wave” drag must be parameterized. Here we highlight the importance of internal drag from topography with scales that cannot radiate internal waves, but may be highly nonlinear, and we propose a simple parameterization of this drag that has a minimum of fit parameters compared to existing schemes. The parameterization smoothly transitions from a quadratic drag law () for low Nh/u0 (linear wave dynamics) to a linear drag law () for high Nh/u0 flows (nonlinear blocking and hydraulic dynamics), where N is the stratification, h is the height of the topography, and u0 is the near-bottom velocity; the parameterization does not have a dependence on Coriolis frequency. Simulations carried out in a channel with synthetic bathymetry and steady body forcing indicate that this parameterization accurately predicts drag across a broad range of forcing parameters when the effect of reduced near-bottom mixing is taken into account by reducing the effective height of the topography. The parameterization is also tested in simulations of wind-driven channel flows that generate mesoscale eddy fields, a setup where the downstream transport is sensitive to the bottom drag parameterization and its effect on the eddies. In these simulations, the parameterization replicates the effect of rough bathymetry on the eddies. If extrapolated globally, the subinertial topographic scales can account for 2.7 TW of work done on the low-frequency circulation, an important sink that is redistributed to mixing in the open ocean.
Identifying Risk Factors and Incidence Rates for Recurrent Cesarean Scar Pregnancy: A Nested Case-Control Study

Background: Cesarean scar pregnancy (CSP) is a rare and dangerous ectopic pregnancy. CSP is a late severe complication of cesarean section. In recent years, with the introduction of the comprehensive second birth policy in China, the incidence of CSP and recurrent CSP has increased. However, there are no clear data available regarding the risk factors related to recurrent CSP in the literature. To identify risk factors and incidence rates for recurrent CSP. Methods: A total of 1000 CSP patients were followed up for 66 ± 19.5 months. Among them, 86 developed recurrent CSP during the follow-up period (group 1), and the remaining without recurrence were group 2. The clinical data of these cases were reviewed in this retrospective study. Results: The incidence rate of recurrent CSP is 8.6%, and the risk factors were a history of ectopic pregnancy and prior abortions. The incidence of RCSP in patients >-35-years-old was significantly lower than that in patients <35-years-old (P=0.031). Conclusions: Previous ectopic pregnancy is an independent risk factor for RCSP. Additionally, the higher the number of induced abortions, the higher the incidence of RCSP.
Polarimétrie harmonique et spectroscopie de photoionisation attoseconde

La physique attoseconde est un domaine en pleine expansion, intrinsequement lie au processus de generation d’harmoniques d’ordre eleve. Cette emission, sous forme d’un train d’impulsions attosecondes ou d’une impulsion attoseconde isolee, constitue une source de lumiere dans le domaine spectral extreme-UV (XUV), ultra-breve, coherente, parfaitement synchrone du champ generateur. Deux thematiques ont ete abordees. La premiere consiste en la caracterisation complete de l’etat de polarisation des harmoniques par Polarimetrie Moleculaire en collaboration avec l’ISMO-Orsay. Cette technique est basee sur la mesure de la distribution angulaire des photoelectrons dans le referentiel moleculaire lors de l’ionisation dissociative de la molecule de NO. Nous l’appliquons a trois configurations produisant un rayonnement harmonique polarise elliptiquement. Nous obtenons ainsi, pour la premiere fois, la valeur absolue de l’ellipticite harmonique, son signe, ainsi que le taux de depolarisation.La seconde thematique est la photoionisation attoseconde resonante : nous avons etudie la photoionisation de l’helium au voisinage de la resonance d'autoionisation 2s2p a 60.15eV, excitee par une impulsion XUV accordable et sondee par une impulsion laser IR en utilisant la technique RABBIT, qui permet la mesure de l’amplitude et de la phase spectrales de la transition resonante a deux photons. Il est ainsi possible de reconstruire dans le domaine temporel, le paquet d'ondes electronique (POE) a 2 photons. Ces mesures ont ete completees par des simulations effectuees par nos collaborateurs a UAM-Madrid et au LCPMR-Paris, qui montrent que, dans nos conditions experimentales, ce paquet a deux photons est une image fidele du paquet resonant a un photon. Ceci represente la premiere reconstruction de la dynamique temporelle d’une resonance non perturbee par le champ laser, avec une resolution attoseconde.
Automatic Liver Tumor Segmentation based on Multi-level Deep Convolutional Networks and Fractal Residual Network

ABSTRACT The liver is a very important and complex organ in our body. Efficient liver segmentation is a very important interesting and challenging task in the field of medical image processing. The abdomen consists of many organs among which the liver consists of very important parts, such as right lobule, left lobule and hepatic duct. In this research work, for computed tomography (CT) images we designed a feasible upstream approach to segment a liver region from abdomen using multi-level deep convolutional network and Fractal Residual Network (FRN). Our convolutional neural network is designed in such a way that it learns to allot different probabilities for each super pixel based on different regions of the liver by these indirectly different classes are created based on different intensities of super pixels. Further FRN is used to identify the tumor region and finally refinement of tumor segmentation is done with active contour model method. The proposed model (MDCN + FRN) is evaluated on CT images 125 patients from TCI dataset and achieved a dice similarity in an average of 0.89 in training and dice similarity in an average of 0.86 in testing. Compared to other segmentation methods, the experiment conducted shows better performance from proposed method.
Metal-free chloroamidation of indoles with sulfonamides and NaClO

An efficient and rapid protocol for chloroamidation of indoles with sulfonamides and aqueous NaClO has been developed. The reaction completes in less than half an hour at room temperature without any transition metals. Both indoles and sulfonamides can be easily varied with high functional group tolerance. A variety of structurally diverse 3-chloro-2-amidoindoles are prepared with up to 97% yields.
Active Funds and Bundled News

We use trade-level data to examine the role of actively managed funds (AMFs) in earnings news dissemination. We find AMFs are drawn to, and participate disproportionately more in, earnings announcements (EAs) that include bundled managerial guidance. When the two pieces of news are directionally inconsistent, AMFs trade in the direction of future guidance rather than current earnings. AMFs exhibit an ability to discern, and adapt their trading to, the bias in bundled guidance. While AMF trades at EAs are generally more profitable than their non-EA trades, this result reverses when guidance bias is extreme. Overall, we find increased AMF trading during EAs leads to faster price adjustment. Collectively, these findings suggest AMFs are sophisticated processors of bundled earnings news, and their trading generally improves market price discovery.
The Drying Rate of Chlorella pyrenoidosa Using an Oven in Bioethanol Production

The production of bioethanol from microalgae goes through several stages, including cultivation, harvesting, drying, storage, and conversion to bioethanol. Nearly 40% of the total energy consumed in the bioethanol production from microalgae is from drying. This research aims to study the drying rate model of Chlorella pyrenoidosa using an oven. The drying is carried out at the temperatures of 50, 60, and 70 oC. The initial moisture content of Chlorella pyrenoidosa was 317.798% dry weight. The results showed that at the temperatures of 50, 60, and 70 oC, the critical moisture content was 9.108, 7.583, and 6.93% dry weight, while the equilibrium moisture content was 3.172, 3.158, and 3.109% dry weight. The most optimal drying is at 70 oC and the drying rate gets faster as the temperature does too. The Page model is better at describing the drying rate of Chlorella pyrenoidosa using an oven than the Newton model. The drying speed constants (k) were 0.00056, 0.00061, and 0.00208, at 50, 60, and 70 oC, respectively.
Cover Crop Complements Flue Gas Desulfurized Gypsum to Improve No-till Soil Quality

ABSTRACT Integration of flue gas desulfurized gypsum (FGD-gypsum) with cover crops is expected to improve soil quality (SQ). Our objectives were to evaluate the impact of FGD-gypsum and rye on SQ and the contribution of core indicators to account for SQ variability in a rainfed corn-soybean system. A completely randomized design (CRD) with two FGD-gypsum rates (control vs. 1,120 kg/ha) x two cover crops (control vs. rye) was conducted. Results showed that both FGD-gypsum and cover crop variably affected soil properties; however, their impact on SQ was more pronounced when integrated. Soil bio-efficiency increased via a large microbial biomass (SMB) pool and higher enzyme activities with a decrease (38%) in microbial catabolism (qCO2). Soil chemical balancing increased 15% by active carbon (AC), 26% by active nitrogen (AN), 50% by particulate organic carbon (POC), 58% by particulate organic nitrogen (PON) and 53% by particulate organic phosphorus (POP) contents. Improved physical stability increased aggregate stability (>250 µm) contributed to higher POC, PON, and POP enrichment within aggregates. The increased bio-efficiency, chemical balancing, and physical stability as impacted by FGD-gypsum and cover crop consequently improved SQ. Principal components analysis (PCA) identified eight indicators to calculate for minimum dataset SQ index (SQIMDS), which explained for 86% of the variability in generalized SQI (SQIgen). A lack of non-significant difference between SQIg and SQIMDS suggesting that SQIMDS can be consistently used to quantify, compare, and predict SQ. A greater use of FGD-gypsum with cover crops will be important for proactive recycling of industrial by-products for growing crops.
Enhancing Paraoxon Binding to Organophosphorus Hydrolase Active Site

Organophosphorus hydrolase (OPH) is a metalloenzyme that can hydrolyze organophosphorus agents resulting in products that are generally of reduced toxicity. The best OPH substrate found to date is diethyl p-nitrophenyl phosphate (paraoxon). Most structural and kinetic studies assume that the binding orientation of paraoxon is identical to that of diethyl 4-methylbenzylphosphonate, which is the only substrate analog co-crystallized with OPH. In the current work, we used a combined docking and molecular dynamics (MD) approach to predict the likely binding mode of paraoxon. Then, we used the predicted binding mode to run MD simulations on the wild type (WT) OPH complexed with paraoxon, and OPH mutants complexed with paraoxon. Additionally, we identified three hot-spot residues (D253, H254, and I255) involved in the stability of the OPH active site. We then experimentally assayed single and double mutants involving these residues for paraoxon binding affinity. The binding free energy calculations and the experimental kinetics of the reactions between each OPH mutant and paraoxon show that mutated forms D253E, D253E-H254R, and D253E-I255G exhibit enhanced substrate binding affinity over WT OPH. Interestingly, our experimental results show that the substrate binding affinity of the double mutant D253E-H254R increased by 19-fold compared to WT OPH.