Miracle-dz/UniFAR-FTUs huggingface dataset:
A HAZARD MAP FOR LIQUEFACTION-INDUCED ROAD SUBSIDENCE

In the 2011 Off the Pacific Coast of Tohoku earthquake with a Mw of 9.0, liquefaction-induced damage occurred widely in the Kanto Region, Japan. Urayasu City, Chiba Prefecture, which is located along the Tokyo Bay had been reclaimed in since 1960’s till 1980’s, and approximately 85 % of the city were heavily damaged due to the occurrence of liquefaction. After the earthquake, the authors’ group prepared a liquefaction-induced soilsubsidence map along the coast of the Tokyo Bay, which was obtained from Airborne LiDAR surveys before and after the earthquake. The present study extracted values of ground subsidence at various locations in Urayasu City from the subsidence map. Given the extracted values of soil subsidence along different types of roads and liquefaction potential index, PL, calculated using borehole data, it is found that an increase in the road subsidence with an increase of PL value is more significant for the residential road than that for the main road. In this study, an attempt was made to develop a new liquefaction hazard map based on the relationship between the extracted road subsidence and PL value. Finally, a comparison of estimated liquefaction-induced road subsidence in the hazard map developed and real damages was carried out in order to confirm an applicability of the hazard map.
A CONCEPTUAL FRACTAL MODEL FOR DESCRIBING TIME-DEPENDENT DISPERSIVITY 1

Field studies show that the variance of travel distance often increases nonlinearly with time elapsed after release of solute tracers. The nonlinear relationship between variance of travel distance and time is attributed to the heterogeneity of the porous media. To describe the transport in such a heterogeneous system, a time-dependent dispersivity is necessary. In this paper, the basis for the formulation of the Wheatcraft-Tyler model is discussed and its inadequacy and inconsistencies are presented. As a consequence of the above, we developed a new model, which is similar in appearance to that of Wheatcraft and Tyler. The proposed model indicates that the variance of travel distance for a tracer may grow with time raised to the power of D, where D is close to the fractal dimension of the fractal stream tube and ranges from 1.0 to 2.0. When D equals 2.0, the dispersivity will increase linearly with time, which is consistent with the Mercado model. The applicability of our model was evaluated with three field scale transport experiments: the Cape Cod, the Borden, and the Columbus sites. The obtained D values for all three sites were significantly greater than 1.0. Comparison between our model and the fractional-order advection-dispersion equation reveals that the D value in our model is related to the fractional order.
Developments in solution processable polymer light-emitting diodes

A device structure that enables the combination of phosphorescent green and fluorescent blue emitters in a solution processed polymer organic light-emitting diode device has been developed. Results demonstrate that it is possible to tune the color of emission by appropriate formulation of the polymers that are used. This enabled the development of a warm white device that had CIE coordinates of (0.462, 0.426), and an external quantum efficiency (EQE) of 13.1%. This EQE was limited by the efficiencies of the emitters used rather than through any internal quenching, and thus the device structure offers potential for further development.
Bayesian Optimized Deep Neural Network for Nuisance Event Filter (Computer Vision)

As semiconductor process shrinks, and chips become denser, wafer inspection becomes more and more challenging, and the conventional inspection methods may not be good enough to separate the defect of interest from nuisance. In this report, we demonstrate that deep learning-based defect inspection could be particularly effective. In addition, the combination of deep learning and Bayesian optimization techniques can further improve the efficiency of wafer inspection system.
Survey of SDN trafﬁc ﬂow classiﬁcation approaches

Software-Deﬁned Networking (SDN) is a ﬂexible architecture approach to networking, offering versatility in the degree of control operators may choose to have of their networks, be it with custom-made off the shelf components or customized made-to-order network elements [47]. As the demand for cloud based applications are on the rise, SDNs also need to undergo modiﬁcations to suit the hosted application needs on a dynamic time frame. A key component of managing these changes is effective Trafﬁc Engineering (TE) of the ﬂows typically experienced in normal operational scope of the data center network (DCN). Primary interest of an operator would be to ensure SLA adherence of all applications hosted in the network. This would include effective classiﬁcation of application ﬂows and their appropriate routing, so that there is no loss of data and connectivity. In this paper, a survey of various mechanisms for trafﬁc ﬂow classiﬁcation has been summarized with an aim to provide an overview for the beginners in SDN TE research area. The approaches are also evaluated against multi-dimensional parameters to aid operators in opting for the best possible TE approach according to their network needs. Recent advances in switch software and hardware development have also been considered to provide a holistic overview to researchers in this ﬁeld.
Roles of Customer Satisfaction and Customer Perceptions in Relationships between The Emotional Labor Performance

This paper presents an analysis of the relationships of Customer satisfaction and customer perceptions in higher education on emotional employee’s performance. To gather information, questionnaires were applied to 670 students distributed in the Fucalty of Business and Economics at Badr University. The researcher used the methodology of correlation that explains such effects. The results show that when there is a high level of deep acting, this affects the customer satisfaction positively. The researcher also found that the customer perception has positively related to deep acting while surface acting has negative relationships to both customer satisfaction and customer perceptions.
Provider Perspectives on Barriers and Facilitators to Postpartum Care for Low-Income Individuals

Background: Recent paradigm shifts in postpartum care have conceptualized the “fourth trimester” as a critical transitional period requiring tailored, ongoing health care. However, this concept presents challenges for providers, especially in low-resource settings. Our objective was to understand providers' perspectives on challenges in postpartum care to highlight strategies for optimizing care. Methods: Focus groups were conducted using a semistructured interview guide to elicit perspectives on barriers and facilitators to postpartum care. Participants included physicians, nurses, and social workers who care for low-income postpartum individuals. Interviews explored the provider experience of postpartum care, with a focus on barriers experienced by patients and providers, and tools for maintaining engagement. Analysis was performed using the constant comparative method and framed by the Social Ecological Model. Results: Participants (N = 26) all acknowledged the importance of the “fourth trimester” but identified multiple barriers to providing optimal postpartum care. Challenges providers perceived for patients and those they perceived for themselves often overlapped, including difficulty with appointment scheduling, insurance limitations, lack of provider continuity, and knowledge gaps. Providers identified ease of referrals to specialists, access to tangible services (e.g., contraception), and enhanced care coordination (e.g., patient navigation) as potential facilitators of improved postpartum care. Conclusions: Obstetric providers recognize the importance of postpartum care yet highlighted significant systems- and patient-based barriers to achieving optimal care. The development and implementation of postpartum care delivery system redesign, such as the use of patient navigators to improve health care utilization and resource attainment, may enhance care during this critical time. Clinical Trial No.: NCT03922334.
First records of the fanged frogs Limnonectes bannaensis Ye, Fei & Jiang, 2007 and L. utara Matsui, Belabut & Ahmad, 2014 (Amphibia: Anura: Dicroglossidae) in Thailand

Abstract Background The taxonomic status of the Thai populations belonging to the Limnonectes kuhlii species complex is controversial, due to phenotypic similarity in the cryptic species complex. Recently, some studies on this group in Thailand have discovered four new species: L. taylori, L. megastomias, L. jarujini and L. isanensis. Even so, the diversity of this group is still incomplete. New information Based on an integrative approach encompassing genetic and morphological analyses, we conclude that the Limnonectes populations from Nan Province (northern) and Yala Province (southern) of Thailand are conspecific with L. bannaensis Ye, Fei & Jiang, 2007 and L. utara Matsui, Belabut & Ahmad, 2014, respectively. These are the first records of these species in Thailand. Our study highlights the importance of using DNA sequence data in combination with morphological data to accurately document species identity and diversity. This is especially important for morphologically cryptic species complexes and sympatrically occurring congeners.
The impact of neoadjuvant concurrent chemoradiation on exosomal markers (CD63 and CD9) expression and their prognostic significance in patients with rectal adenocarcinoma

Introduction: Exosomes have pivotal roles in cancer development. The impact of neoadjuvant concurrent chemoradiation (NCCR) on exosomal markers (CD63 and CD9) expression and their prognostic significance in patients with rectal adenocarcinoma are yet to be explored. Materials and Methods: Between 2015 and 2018, 33 patients had rectal adenocarcinoma treated with NCCR and had pre-NCCR biopsy and post-NCCR resected rectum. CD63 and CD9 expression was assessed by immunohistochemistry (IHC). The short-term surrogate endpoint neoadjuvant rectal (NAR) score was used for assessment of prognostic significance. Un-Paired t-test was used for statistical analysis. Results: The mean tumor CD63 and CD9 scores in pre-NCCR biopsy vs. post-NCCR resected rectum were 106 vs. 165 (P = 0.0022) and 136 vs. 215 (P < 0.0001) respectively. The mean tumor CD63 and CD9 scores respectively in pre-NCCR biopsy was 99 and 130 in patients with low-intermediate NAR score compared to 117 and 144 in patients with high NAR score (P = 0.4934) (P = 0.5519). The mean tumor CD63 and CD9 scores respectively in post-NCCR resected rectum was 155 and 205 in patients with low-intermediate NAR score compared to 180 and 230 in patients with high NAR score (P = 0.3793) (P = 0.2837). Conclusions: The expression of the exosomal markers (CD63 and CD9) increased in patients with rectal adenocarcinoma after treatment with NCCR. The exosomal markers (CD63 and CD9) may have a prognostic significance. There was a trend for higher CD63 and CD9 expression in patients with high NAR score compared with low-intermediate NAR scores. The lack of statistical significance is likely due to the small sample size.
Intranasal esketamine use in bipolar disorder: A case report

Over the past few years, intranasal esketamine has been FDA-approved for treatment-resistant depression as well as MDD with suicidal ideation. In the clinical trials leading to the recent FDA approvals, subjects with a diagnosis of bipolar disorder were excluded from participation in the trial. The manufacturer of intranasal esketamine states that it “has not been studied, and is not indicated, for patients with bipolar disorder. ” Antidepressants are commonly associated with having the potential to induce rapid cycling in patients with bipolar disorder, though the mechanism is not fully understood. This case report demonstrates the potential safety of intranasal esketamine in combination with mood stabilizer therapy in a patient diagnosed with bipolar disorder without recent history of manic or hypomanic episodes.
Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase

Introduction: Treatment options for biliary tract cancer (BTC) are very limited. It is necessary to investigate actionable genes and candidate drugs using a sophisticated knowledgebase (KB) and characterize BTCs immunologically for evaluating the actionability of molecular and immune therapies. Materials and Methods: The genomic and transcriptome data of 219 patients with BTC who underwent surgery were analyzed. Actionable mutations and candidate drugs were annotated using the largest available KB of the Asian population (CancerSCAN®). Predictive biomarkers of immune checkpoint inhibitors were analyzed using DNA and RNA sequencing data. Results: Twenty-two actionable genes and 43 candidate drugs were annotated in 74 patients (33.8%). The most frequent actionable genes were PTEN (7.3%), CDKN2A (6.8%), KRAS (6.4%). BRCA2, CDKN2A, and FGFR2 mutations were most frequently identified in case of intrahepatic cholangiocarcinoma. PTEN and CDKN2A mutations were associated with significantly shorter overall survival. PD-L1 and PD-1 expression was significantly higher in case of extrahepatic cholangiocarcinoma and T-cell-high expression. In total, 49.7% of cases were evaluated as having actionability for molecular therapy or immune checkpoint inhibitors. Conclusions: Identifying actionable genes and candidate drugs using the KB contribute to the development of therapeutic drugs and personalized treatment for BTC.
Age, size and body condition do not equally reflect population response to habitat change in the common spadefoot toad Pelobates fuscus

Urbanization impacts biodiversity both directly through physical expansion over land, and indirectly due to land use conversion and human behaviors associated with urban areas. We assessed the response of a common spadefoot toad population (Pelobates fuscus) to habitat loss and fragmentation resulting from urban development by studying changes in size, body condition and age parameters. We compared samples collected in the early 2000s (sample A) and later on during 2012–2014 (sample B). The terrestrial habitats in the study area were severely reduced and fragmented due to the expansion of the human settlement. We found no significant differences in the age parameters between the two sampling periods; the median lifespan shortened from 3.5 (sample A) to 3.0 years (sample B), while the other age parameters were similar in both samples. In contrast, snout-vent length, body mass and body condition experienced a significant decrease over time. Our results suggest that changes in body size and body condition, rather than age parameters, better reflect the response of the common spadefoot toad population to declining habitat quality. Therefore, body measurements can provide reliable estimates of the impact of habitat degradation in amphibian populations.
Prevalence, Laboratory Findings and Clinical Characteristics of Campylobacteriosis Agents among Hospitalized Children with Acute Gastroenteritis in Lebanon

Purpose Campylobacter species are currently the most common cause of bacterial gastroenteritis. In Lebanon, Campylobacter infection occurrence is underdiagnosed owing to the lack of specific culture and rapid test kits, particularly among children. This study aimed to evaluate the prevalence, laboratory findings, and clinical characteristics of Campylobacter infection in hospitalized children with acute gastroenteritis in South Lebanon. Methods We conducted a 6-month retrospective cohort study between January and June 2018, including 291 children aged between 1 month and 12 years, who were admitted to a tertiary healthcare center in South Lebanon. The medical files of the patients were reviewed to retrieve the required clinical information, including clinical and laboratory data. Results The prevalence of campylobacteriosis agents in pediatric patients with acute gastroenteritis is 12.02%. Patients infected with Campylobacter had more severe acute gastroenteritis than Campylobacter-negative patients and often presented with high-grade fever, diarrhea episodes more than six times per day, diarrhea lasting for more than five days, and dehydration. Indeed, children with high-grade fever (≥38.5°C) were five times more likely to test positive for Campylobacter than those with low-grade fever. In addition, the results showed a higher Vesikari score for the majority of Campylobacter-positive patients with severe acute gastroenteritis compared to a moderate profile for Campylobacter-negative patients. Conclusion The present study findings highlight that Campylobacter infection is frequent among children with acute gastroenteritis. Therefore, the detection of Campylobacter should be carried out for the diagnosis of human gastroenteritis in Lebanon, along with the detection of routine enteropathogens.
Thermochemical lignin depolymerization and conversion to aromatics in subcritical methanol: effects of catalytic conditions

Lignin is the second most abundant polymer and a renewable resource with a high energy density, but it is considered to be difficult to process because of the high reactivity of its building blocks that undergo recombination reactions leading to the formation of THF insoluble residues (char). In this study, solvolytic depolymerization was studied under three different catalytic conditions. A homogeneous catalyst NaOH, a heterogeneous catalyst HZSM-5 and the solid waste of iron turnings from lathe machining (as a consumable catalyst) were studied. We observed that HZSM-5 showed a similar lignin depolymerization efficiency to NaOH. HZSM-5 showed highest ethyl acetate extractibles with the lowest THF insoluble residue formation during lignin depolymerization and the Mw of lignin decreased from 5000 mol g−1 to <550 mol g−1. The products formed were mainly alkyl substituted phenols, which have high industrial applications. Iron turnings showed efficient reduction in the average molecular weight of products as compared to the original lignin along with adversely increased THF insoluble residue formation and a low yield of alkyl substituted phenols. In all the cases, based on the product profile obtained, the behavior of the catalytic action is explained using a schematic representation of the mechanisms.
iCAT: diagnostic assessment tool of immunological history using high-throughput T-cell receptor sequencing

The pathogen exposure history of an individual is recorded in their T-cell repertoire and can be accessed through the study of T-cell receptors (TCRs) if the tools to identify them were available. For each T-cell, the TCR loci undergoes genetic rearrangement that creates a unique DNA sequence. In theory these unique sequences can be used as biomarkers for tracking T-cell responses and cataloging immunological history. We developed the immune Cell Analysis Tool (iCAT), an R software package that analyzes TCR sequencing data from exposed (positive) and unexposed (negative) samples to identify TCR sequences statistically associated with positive samples. The presence and absence of associated sequences in samples trains a classifier to diagnose pathogen-specific exposure. We demonstrate the high accuracy of iCAT by testing on three TCR sequencing datasets. First, iCAT successfully diagnosed smallpox vaccinated versus naïve samples in an independent cohort of mice with 95% accuracy. Second, iCAT displayed 100% accuracy classifying naïve and monkeypox vaccinated mice. Finally, we demonstrate the use of iCAT on human samples before and after exposure to SARS-CoV-2, the virus behind the COVID-19 global pandemic. We were able to correctly classify the exposed samples with perfect accuracy. These experimental results show that iCAT capitalizes on the power of TCR sequencing to simplify infection diagnostics. iCAT provides the option of a graphical, user-friendly interface on top of usual R interface allowing it to reach a wider audience.
The Relationship between Functional Constipation and Major Dietary Patterns in Iranian Adults: Findings from the Large Cross-Sectional Population-Based SEPAHAN Study

Although associations between dietary patterns and risk of chronic conditions have recently received increased attention, few studies have examined the relationship between major dietary patterns and risk of constipation. We collected dietary data using a validated dish-based, 106-item semi-quantitative Food Frequency Questionnaire on 4,763 adults aged 18∼55 years. Data on anthropometric measures were collected through self-administered questionnaires. Functional constipation was defined based on the Iranian validated version of Rome III. Factor analysis followed by a varimax rotation was applied to derive major dietary patterns from 39 predefined food groups, and logistic regression was used for association analysis. Three major dietary patterns were extracted: traditional (TD), fruit and vegetables dominant (FVD), and Western (WD). The association between TD and constipation was not significant for both genders and for the total sample. However, in the crude model and the fully adjusted model, poor adherence to the FVD was associated with a higher risk of constipation in men and in the total sample. In addition, we observed a significantly lower risk of constipation in the total sample and in female participants with low adherence to WD; however, this was not significant for male participants. Further studies in other populations, and future prospective studies, are required to reiterate these results.
Cross neutralization of emerging SARS-CoV-2 variants of concern by antibodies targeting distinct epitopes on spike

Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have arisen that exhibit increased viral transmissibility and partial evasion of immunity induced by natural infection and vaccination. To address the specific antibody targets that were affected by recent viral variants, we generated 43 monoclonal antibodies (mAbs) from 10 convalescent donors that bound three distinct domains of the SARS-CoV-2 spike. Viral variants harboring mutations at K417, E484 and N501 could escape most of the highly potent antibodies against the receptor binding domain (RBD). Despite this, we identified 12 neutralizing mAbs against three distinct regions of the spike protein that neutralize SARS-CoV-2 and the variants of concern, including B.1. 1.7 (alpha), P.1 (gamma) and B.1. 617.2 (delta). Notably, antibodies targeting distinct epitopes could neutralize discrete variants, suggesting different variants may have evolved to disrupt the binding of particular neutralizing antibody classes. These results underscore that humans exposed to wildtype (WT) SARS-CoV-2 do possess neutralizing antibodies against current variants and that it is critical to induce antibodies targeting multiple distinct epitopes of the spike that can neutralize emerging variants of concern.