Miracle-dz/UniFAR-FTUs huggingface dataset:
Necrotizing and haemorrhagic hepatitis and enteritis in commercial layer pullets

ABSTRACT This case report describes an episode of recurring severe necrotizing and haemorrhagic hepatitis and enteritis experienced in a flock of commercial layer pullets at 12 weeks of age and again at 18 weeks of age in Indiana. Pullets had been vaccinated at 10 weeks old using a trivalent Salmonella Enteritidis (SE)/Newcastle disease/infectious bronchitis oil-emulsion-inactivated vaccine. The pullets were found dead at 12 weeks with firm but friable, enlarged, haemorrhagic livers, enlarged spleens, and necrohaemorrhagic intestines. Histopathologic findings were consistent with a necrotizing and haemorrhagic enteritis and hepatitis. Livers had multiple intra-sinusoidal thrombi, intestines contained Gram-positive bacterial colonies, and spleens had marked lymphoid depletion. The pullets seemed to improve after antibiotic treatment. Pullets were vaccinated with an inactivated SE vaccine at 14 weeks of age. A second spike of mortality occurred at 18 weeks of age. Although clostridial enteritis and hepatitis were highly suspected in the two cases based on macroscopic and microscopic findings, no significant bacterial or viral agents were isolated from the livers and intestines. In summary, lesions in the liver and intestines are speculated to be due to repetitive vaccination, leading to an anamnestic response by the immune system, and resulting in an immune-mediated response. However, much of the pathogenesis is still unclear, and other causes such as unidentified infectious aetiology, transmissible amyloidosis, and hypersensitivity may need further investigation.
RBL cells as models for in vitro studies of mast cells and basophils

Since their establishment in 1981, RBL‐2H3 cells have been widely used as a mast cell (MC) model. Their ability to be easily grown in culture in large amounts, their responsiveness to FcεRI‐mediated triggers and the fact that they can be genetically manipulated, have provided advantages over primary MCs, in particular for molecular studies relying on genetic screening. Furthermore, the ability to generate clones that stably express proteins of interest, for example, a human receptor, have marked the RBL cells as an attractive MC model for drug screening. Indeed, 3 RBL reporter cell lines (RS‐ATL8, NFAT‐DsRed, and NPY‐mRFP) have been generated providing useful models for drug and allergen screening. Similarly, RBL cells stably expressing the human MrgprX2 receptor provide a unique paradigm for analyzing ligand interactions and signaling pathways of the unique human receptor. Finally, transient co‐transfections of RBL cells allow functional genomic analyses of MC secretion by combining library screening with simultaneous expression of a reporter for exocytosis. RBL cells thus comprise powerful tools for the study of intracellular membrane trafficking and exocytosis and the detection of allergens, vaccine safety studies and diagnosis of allergic sensitization. Their recent uses as an investigative tool are reviewed here.
Graphene onto medical grade titanium: an atom-thick multimodal coating that promotes osteoblast maturation and inhibits biofilm formation from distinct species

Abstract The time needed for the osseointegration of titanium implants is deemed too long. Moreover, the bacterial colonization of their surfaces is a major cause of failure. Graphene can overcome these issues but its wet transfer onto substrates employs hazardous chemicals limiting the clinical applications. Alternatively, dry transfer technique has been developed, but the biological properties of this technique remain unexplored. Here, a dry transfer technique based on a hot-pressing method allowed to coat titanium substrates with high-quality graphene and coverage area >90% with a single transfer. The graphene-coated titanium is cytocompatible, did not induce cell membrane damage, induced human osteoblast maturation (gene and protein level), and increased the deposition of mineralized matrix compared to titanium alone. Moreover, graphene decreased the formation of biofilms from Streptococcus mutans, Enterococcus faecalis and even from whole saliva on titanium without killing the bacteria. These findings confirm that coating of titanium with graphene via a dry transfer technique is a promising strategy to improve osseointegration and prevent biofilm formation on implants and devices.
The role of cadherin genes in five major psychiatric disorders: A literature update

Converging evidence from candidate gene, genome‐wide linkage, and association studies support a role of cadherins in the pathophysiology of five major psychiatric disorders including attention deficit hyperactivity disorder, autism spectrum disorder (ASD), schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD). These molecules are transmembrane proteins which act as cell adhesives by forming adherens junctions (AJs) to bind cells within tissues. Members of the cadherin superfamily are also involved in biological processes such as signal transduction and plasticity that have been implicated in the etiology of major psychiatric conditions. Although there are over 110 genes mapped to the cadherin superfamily, our literature survey showed that evidence of association with psychiatric disorders is strongest for CDH7, CHD11, and CDH13. Gene enrichment analysis showed that those cadherin genes implicated in psychiatric disorders were overrepresented in biological processes such as in cell‐cell adhesion (GO:0007156 & GO:0098742) and adherens junction organization (GO:0034332). Further, cadherin genes were also mapped to processes that have been linked to the development of psychiatric disorders such as nervous system development (GO:0007399). To further understand the role of cadherin SNPs implicated in psychiatric disorders, we utilized an in silico computational pipeline to functionally annotate associated variants. This analysis yielded eight variants mapped to PCDH1‐13, CDH7, CDH11, and CDH13 that are predicted to be biologically functional. Functional genomic evaluation is now required to understand the molecular mechanism by which these variants might confer susceptibility to psychiatric disorders.
Vinflunine for the treatment of advanced or metastatic transitional cell carcinoma of the urothelial tract: an evidence-based review of safety, efficacy, and place in therapy

Background A systematic review and meta-analysis of the use of systemic vinflunine (VIN) in the treatment of urothelial carcinoma (UC) was performed to evaluate its efficacy based on current available clinical data. Methods This review was prospectively registered at the International Prospective Register of Systematic Reviews, PROSPERO (registration CRD42016049294). Electronic databases including MEDLINE®, Embase®, Cochrane Central Register of Controlled Trials, and Web of Science were searched through December 2016. We performed a meta-analysis of the published data. Primary end points were progression-free survival (PFS) and overall survival (OS). Numerous secondary clinical outcomes were analyzed including response and toxicity data. Results We identified 382 publications, of which 35 met inclusion criteria for this review representing 29 unique studies. A total of 2,255 patients received VIN for the treatment of UC in the included studies. OS and PFS were analyzed in a pooled Kaplan–Meier analysis. Response data were available for 1,416 VIN-treated patients with random effects proportion of complete response in 1%, partial response in 18%, and overall response rate of 21%. Toxicity analysis revealed fatigue (40.1%), nausea (33.9%), constipation (34.1%), and alopecia (26.0%) as the most prevalent overall non-hematologic adverse events (AEs). Most prevalent grade 3–4 AEs were fatigue (10.2%), abdominal pain (8.2%), myalgias (2.5%), and nausea (2.3%). Most common hematologic AEs of all grades were anemia (56.6%), neutropenia (46.0%), thrombocytopenia (25.5%), and febrile neutropenia (6.6%). Grade 3–4 hematologic AEs had the following pooled rates: neutropenia, 24.6%; anemia, 10.2%; febrile neutropenia, 5.4%; and thrombocytopenia, 3.0%. Conclusion VIN has been explored as a combination first-line treatment as well as a single-agent second-line, third-line, and maintenance therapy for advanced and metastatic UC. In first-line treatment of UC, either as a maintenance agent after cisplatin or as a primary combination therapy, VIN may be a promising alternative to current treatments. Further studies are needed to compare first-line combination VIN regimens to the current standard of care in order to assess long-term survival outcomes. Second- and third-line VIN monotherapy does provide a proven, although limited, survival benefit in platinum-refractory patients.
Into the wild—WAMBAM goes to Canada

The sixth Wild Animal Models Bi‐Annual Meeting was held in July 2017 in Québec, with 42 participants. This report documents the evolution of questions asked and approaches used in evolutionary quantitative genetic studies of wild populations in recent decades, and how these questions and approaches were represented at the recent meeting. We explore how ideas from previous meetings in this series have developed to their present states, and consider how the format of the meetings may be particularly useful at fostering the rapid development and proliferation of ideas and approaches.
A Prospective Study of Physical Activity Intensity and Change in Adiposity in Middle-Aged Women

Purpose. To determine the extent to which objectively measured intensity of physical activity (PA) predicts change in body fat (BF%) in women. Design. Prospective cohort study of PA intensity and body composition in middle-aged women. Setting. The study took place in a metropolitan Mountain West community. Subjects. Two hundred and twenty-eight women participated in two assessment periods separated by 20 months. Measures. Each assessment period consisted of seven consecutive days of monitoring, followed by body composition testing. Analysis. The general linear model using partial correlations and Mantel-Haenszel χ2 tests were performed. Results. At baseline and follow-up, women who participated in vigorous PA were leaner than women who participated in moderate or light PA (p < .05). Longitudinal results indicated that a greater proportion of women who decreased PA intensity over the 20 months also increased BF% (66%), compared to participants who increased or maintained PA intensity (47%) (p < .05). Conclusions. PA intensity seems to play a role in long-term weight maintenance. Reducing PA intensity increases the risk of BF% gain in women. Efforts to help women maintain PA intensity along with other weight management strategies may prove beneficial in preventing unwanted body fat gain in middle-aged women.
Socioeconomic Status and the Prevalence of Type 2 Diabetes Among Adults in Northwest China

Purpose The purpose of the study was to investigate (1) the associations of socioeconomic status, lifestyle risk factors, and the prevalence of newly diagnosed type 2 diabetes and (2) the mediating effects of lifestyle risk factors on the association of socioeconomic status and the prevalence of newly diagnosed type 2 diabetes among Chinese adults in northwest China. Methods Based on a correlational design and random multistage sampling in communities (N = 3243), data were collected through face-to-face interviews and anthropometric measurements. Education, occupation, and income were considered indicators of socioeconomic status. Results Approximately 7.5% persons interviewed had newly diagnosed type 2 diabetes. Chi-square analyses showed that higher socioeconomic indicators (higher income, nonmanual occupation) were associated with increased risk. Lifestyle risk factors, including alcohol use, unhealthy diet, and higher body mass index, were significantly positively associated with type 2 diabetes. Adjusting for demographic characteristics, hierarchical logistic regression analyses showed that unhealthy diet and high body mass index were significantly associated with type 2 diabetes. Conclusions Higher incomes and nonmanual occupations were related to a greater prevalence of type 2 diabetes, and high body mass index mediated these associations. These findings suggest that interventions for type 2 diabetes in China should be targeted at populations with high socioeconomic status and nonmanual occupations to reduce lifestyle risk factors and prevent diabetes.
Imputation of missing healthcare data

In the field of data mining, missing values has always been a crucial factor. Incorrect imputation of missing values could lead to inaccurate research as well as wrong predictions. Developing a generalized imputation strategy that can be used across a variety of dataset is very hard. Because each dataset has its attributes and characteristics, and finding another dataset of similar property could be a very hard task. In Bangladesh, real healthcare data is very noisy which makes the knowledge discovery by health researchers very difficult. One of the main sources of noise in healthcare data is missing values. In this paper, we presented a general model for the imputation of any kind of missing data. We also implemented three different algorithms namely Amelia, FURIA, and MICE in real healthcare dataset to impute missing values. Experimental results on 65000 patient records show that MICE algorithm performs better among the three.
A self-organized scheme for privacy and security management in wireless sensor media networks

In this paper, we present a self-organization scheme for privacy and security management in wireless sensor media networks (WSMN) to not only protect the data but also detect and locate the malicious behavior. During communication, a chaos-driven tunnel is designed with the consideration of the characteristics of media data. A scheme for data-aware information agents are introduced to enhance the public key cryptography based confidential communication. A simulation and related analysis are presented. The scheme does not require a topology to guarantee the performance of self-organization.
Core Components for a Clinically Integrated mHealth App for Asthma Symptom Monitoring

Abstract Background mHealth apps may be useful tools for supporting chronic disease management. Objective Our aim was to apply user-centered design principles to efficiently identify core components for an mHealth-based asthma symptom–monitoring intervention using patient-reported outcomes (PROs). Methods We iteratively combined principles of qualitative research, user-centered design, and “gamification” to understand patients' and providers' needs, develop and refine intervention components, develop prototypes, and create a usable mobile app to integrate with clinical workflows. We identified anticipated benefits and burdens for stakeholders. Results We conducted 19 individual design sessions with nine adult patients and seven clinicians from an academic medical center (some were included multiple times). We identified four core intervention components: (1) Invitation—patients are invited by their physicians. (2) Symptom checks—patients receive weekly five-item questionnaires via the app with 48 hours to respond. Depending on symptoms, patients may be given the option to request a call from a nurse or receive one automatically. (3) Patient review—in the app, patients can view their self-reported data graphically. (4) In-person visit—physicians have access to patient-reported symptoms in the electronic health record (EHR) where they can review them before in-person visits. As there is currently no location in the EHR where physicians would consistently notice these data, recording a recent note was the best option. Benefits to patients may include helping decide when to call their provider and facilitating shared decision making. Benefits to providers may include saving time discussing symptoms. Provider organizations may need to pay nurses extra, but those costs may be offset by reduced visits and hospitalizations. Conclusion Recent systematic reviews show inconsistent outcomes and little insight into functionalities required for mHealth asthma interventions, highlighting the need for systematic intervention design. We identified specific features for adoption and engagement that meet the stated needs of users for asthma symptom monitoring.
Effect of maternal position on fetal behavioural state and heart rate variability in healthy late gestation pregnancy

Fetal behavioural state in healthy late gestation pregnancy is affected by maternal position. Fetal state 1F is more likely to occur in maternal supine or right lateral positions. Fetal state 4F is less likely to occur when the woman lies supine or semi‐recumbent. Fetal state change is more likely when the woman is supine or semi‐recumbent. Fetal heart rate variability is affected by maternal position with variability reduced in supine and semi‐recumbent positions.
Utility of a Novel Reflective Marker Visualized by Flash Photography for Assessment of Personnel Contamination During Removal of Personal Protective Equipment

In an experimental study, the frequency of contamination of healthcare personnel during removal of contaminated personal protective equipment (PPE) was similar for bacteriophage MS2 and a novel reflective marker visualized using flash photography. The reflective marker could be a useful tool to visualize and document personnel contamination during PPE removal. Infect Control Hosp Epidemiol 2016;37:711–713
A modified noise assisted EMD to extract low-frequency modes present in a WAMS data of dynamic power system

Empirical Mode Decomposition(EMD)is incapable of separating mode frequencies present in a octave because it suffers from mode mixing problem. This paper proposes modification to noise-assisted Empirical Mode Decomposition technique which can effectively improve the mode mixing problem. The exsiting and proposed improvements to these methodologies in this paper are first applied to an artificial test signal to verify the ability in separating mixing modes. Thereafter, the real-time data of Eastern Interconnect Phasor Project (EIPP), U.S.A are analyzed. Further different modal frequency components are extracted by EMD, Ensemble Empirical Mode Decomposition(EEMD), Complete Ensemble Empirical Decomposition with Adaptive Noise (CEEMDAN), and modified CEEMDAN. Hilbert spectrum analysis is carried out to compare instantineous frequency variation of various extracted modes. From the simulation results, it is concluded that EEMD technique works well in fixing mode mixing problem than previously used EMD based techniques but the problem of noise in the extracted modes of EEMD still remains which is overcome by CEEMDAN technique. CEEMDAN suffers from the problem of presences of noise in the extracted modes and existence of spurious mode, which are then overcome by modified CEEMDAN.
Therapeutic Interventions Focused on the Family of Bipolar Patients

Background: Although genetic and biological factors are crucial in the pathophysiology of bipolar disorder, the importance of psychosocial and familial factors in triggering or mitigating relapses warrants the implementation of psychotherapeutic interventions. The authors review and criticize the role of family intervention in bipolar disorder. Methods: The main computerized databases (Medline, Psychological Abstracts, Current Contents) have been searched for the terms ‘family intervention’, ‘family management’, ‘family therapy’, ‘psychotherapy’, ‘psychoeducation’ and ‘bipolar disorder’. Results: Some studies have associated high expressed emotion in relatives and poorer outcome in bipolar disorder. Studies on families of bipolar patients seem to support that family intervention as adjunctive therapy to pharmacological treatment may reduce the number of relapses and hospitalizations, improving familial, occupational and social functioning. However, controlled studies are scarce and most of them have a great number of methodological pitfalls such as small sample size, uncontrolled pharmacological treatment, absence of long follow-up and biased populations, among others. Conclusions: Both bipolar patients and their relatives could benefit from family intervention as adjunctive treatment to pharmacotherapy. Nevertheless, it would be necessary to design further investigations avoiding some of the limitations listed above, and controlling additionally for psychopathology in family members, and the influence of life events. It would be important to distinguish between causes and effects, studying which factors are involved in family attitudes and determining whether the interactive patterns are variable or stable according to the clinical state of the patient. Finally, it would be useful to design viable, effective and measurable interventions for the accurate delimitation of the role of family intervention in the treatment of bipolar disorder.
The UKIRT Hemisphere Survey : definition and J-band data release.

This paper defines the UK Infra-red Telescope (UKIRT) Hemisphere Survey (UHS) and release of the complete J-band dataset. The UHS provides continuous coverage in the northern hemisphere from a declination of 0 deg to 60 deg by combining the existing Large Area Survey, Galactic Plane Survey and Galactic Clusters Survey conducted under the UKIRT Infra-red Deep Sky Survey (UKIDSS) programme with a new additional ~12,700 sq.deg area not covered by UKIDSS. This data release includes J-band imaging and source catalogues over the new area, which, together with UKIDSS, completes the J-band UHS coverage over the full ~17,900 sq.deg area. 98 per cent of the data in this release have passed quality control criteria, the remaining 2 per cent being scheduled for re-observation. The median 5-sigma point source sensitivity of the released data is 19.6 mag (Vega). The median full width at half-maximum of the point spread function across the dataset is 0.75 arcsec. In this paper, we outline the survey management, data acquisition, processing and calibration, quality control and archiving as well as summarising the characteristics of the released data products. The data are initially available to a limited consortium with a world-wide release scheduled for August 2018.
Reward-Predictive Neural Activities in Striatal Striosome Compartments

Visual Abstract The striatum has been shown to play a critical role in reward prediction. It is composed of two neurochemically and anatomically distinct compartments known as the striosomes and the matrix. The striosomes comprise only about 15% of the striatum by volume and are distributed mosaically therein. Accordingly, it has been difficult to identify striosomal neurons in electrophysiological recordings and it has been unclear whether striosomal neurons, which project to midbrain dopaminergic neurons, engage in reward prediction. In this study, we utilized a mouse line (Sepw1-NP67) selectively expressing Cre in striosomal neurons, combined with endoscopic in vivo calcium imaging to selectively record activities of striosomal neurons during an odor-conditioning task. As mice learned the task, striosomal neurons in the dorsomedial striatum (DMS) showed predictive activities to odor cues that were associated with water rewards or aversive air puffs. These activities were proportional to the expected reward or air-puff intensity. Intriguingly, repeated recordings of the same striosomal neurons over a period of weeks revealed that predictive activities were learning-stage specific. That is, these activities disappeared after continuous training. Furthermore, presentations of rewards or air puffs activated some striosomal neurons. These findings suggest that the striosomes participate in reward prediction with learning stage-specific neural ensembles, and that they also send reward and aversive signals to dopaminergic neurons.