Miracle-dz/UniFAR-FTUs huggingface dataset:
PARATHYROID TRANSPLANTS IN RATS A CO~PAmSON OF Tm~m SURVrVAL T n ~ wrm T~AT OF SvaN GmAa-rs*

The specific reaction generated by an animal against a graft of living tissue received from another member of its species is now generally agreed to be on an immunologic basis. Although the anterior chamber of the eye and those areas within the meninges of the central nervous system are probably examples of exceptions (1, 2) the homograft reaction is an anatomically generalized phenomenon ordinarily (3). The substances appreciated as antigens by the recipient of a homograft have not been finally identified (4), but considerable evidence is at hand which indicates that the genetic difference between donor and recipient can be sensitively revealed by the rejection of a graft transplanted between them (5, 6). Since genetic control of tissue antigenicity seems so well established it is logical to expect that various tissues of the same individual might contain closely similar complements of antigens and that all would be rejected in roughly the same way. For practical reasons skin has been the tissue most intensively studied in grafting experiments, and the timing and vigor of the reaction have been most thoroughly described in such superficial grafts. The technical problems surrounding the proper assessment of viability of buried grafts have raised obstacles to obtaining comparable information for other tissues. This was recognized as a relative limitation, for example, in the adrenal grafting experiments of Medawar and Russell (7). One specific means of determining the functional status of buried grafts was described by Billingham and Parkes (8), who effectively used the state of vaginal cornification of the ovariectomized recipient as a test of ovarian graft survival in rats.
Chapter 2 Market Segmentation Analysis 2 . 1 The Layers of Market Segmentation Analysis

This process is typically a statistical one. Yet, it is exploratory in nature. Many decisions made by the data analyst in the process of extracting market segments from consumer data affect the final market segmentation solution. For market segmentation analysis to be useful to an organisation, therefore, both a competent data analyst, and a user who understands the broader mission of the organisation (or that of their organisational unit when working in a team) need to be involved when market segments are extracted from consumer data. Throughout this book, we use the term user to mean the user of the segmentation analysis; the person or department in the organisation that will use the results from the market segmentation analysis to develop a marketing plan. To ensure that the grouping of consumers is of the highest quality, a number of additional tasks are required, as illustrated in the second layer in Fig. 2.1. All these tasks are still primarily technical in nature. Collecting good data, for example, is critically important. The statistical segment extraction process at the core of market segmentation analysis cannot compensate for bad data. The grouping of consumers can always only be as good as the data provided to the segment extraction method. Upon completion of data collection, but before the actual segment extraction takes place, the data needs to be explored to gain preliminary insight into the nature of the market segmentation study that can be conducted using this data. Finally, after consumers have been grouped into market segments, each of these segments needs to be profiled and described in detail. Profiling and describing segments help users
Standardization and validation of a protocol of zeta potential evaluation by electrophoretic light scattering for nanomaterial characterization

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Standardization and validation of a protocol of zeta potential evaluation by electrophoretic light scattering for nanomaterial characterization Fanny Varenne, Jérémie Botton, Claire Merlet, Jean-Jacques Vachon, Sandrine Geiger, Ingrid Infante, Mohamed Chehimi, Christine Vauthier
Coactivity IsHighlyEfficaciousagainstBothT-and B-cell Acute Lymphoblastic Leukemias In Vivo

Acute lymphoblastic leukemia (ALL) is the most common type of pediatric cancer, although about 4 of every 10 cases occur in adults. The enzyme drug L-asparaginase serves as a cornerstone of ALL therapy and exploits the asparagine dependency of ALL cells. In addition to hydrolyzing the amino acid L-asparagine, all FDA-approved L-asparaginases also have significant L-glutaminase coactivity. Since several reports suggest that L-glutamine depletion correlates with many of the side effects of these drugs, enzyme variants with reduced L-glutaminase coactivity might be clinically beneficial if their antileukemic activity would be preserved. Here we show that novel low L-glutaminase variants developed on the backbone of the FDA-approved Erwinia chrysanthemi L-asparaginase were highly efficacious against both Tand B-cell ALL, while displaying reduced acute toxicity features. These results support the development of a new generation of safer L-asparaginases without L-glutaminase activity for the treatment of human ALL. Significance:A new L-asparaginase–based therapy is less toxic compared with FDA-approved high L-glutaminase enzymes Cancer Res; 78(6); 1549–60. 2018 AACR.
Next generation biometrics : line scan palmprint recognition and door knob hand recognition

Biometrics has been in the spotlight for over a decade. A biometric system authenticates people’s identities using biological and/or behavioral traits. Various biometric applications have been developed, and a vast amount of people have benefited from the convenience of biometrics. The applications of biometrics in everyday life have expanded dramatically. In the meantime, there are new challenges to biometric systems when being used by the general public. In this work, the focus is to investigate the methodology of conventional biometrics design, to improve current biometrics, to practice new biometrics design methodology, and to create new biometrics. Palmprint recognition is the foundation of this improvement. Palmprint recognition is a hand-based biometrics with excellent performance for the large region of interest, stable and unique features, and fast feature extraction and matching method verified by researchers all over the world. However, the applications of palmprint recognition are limited. One major reason for the palmprint recognition not being utilized widely is the lack of a small and compact acquisition system. Then we proposed a line-scan palmprint acquisition system (LPS). LPS uses line scan imaging that makes the system small and flexible. LPS comprises the line scan sensor, the synchronizing unit, and the controller board. With the proposed acquisition system, we collected 8000 images from 250 people. In this huge data set, the equal error rate of LPS is 0.048%, which is comparable to conventional palmprint acquisition systems. Moreover, the volume of the proposed LPS is 94% smaller than conventional systems at least. After the line scan palmprint system, it is realized that a new biometrics design model and new biometric systems are required. This new biometrics design model should emphasize user experience, because the improvements in system level is not enough. The conventional biometrics design model focuses on security performance. They are under the assumption that biometric traits can be extracted better in the standard pose and position than in a deformed pose. This assumption is true with the limitations of both hardware (imaging technology) and algorithms (feature extraction and classification methods). With the recent development in both hardware and algorithms field, this situation has altered. For hardware, the lens and cameras have become tiny in volume. The precision and the resolution of the lens and cameras are far better than five years ago. For algorithms, new feature extraction method and classification method are robust to various interference and deformations. Thus, we proposed the new ergonomic biometrics design model. In this ergonomic biometrics design model, the human factor, both physical and psychological factors, is one of the major concerns in the design stage of building a biometric system. Using this model, we proposed the door knob hand recognition system (DKHRS).
Full Paper In vivo and in vitro characterization of site-specifi c recombination of actinophage R4 integrase

In the lysogenic phase, a temperate phage can integrate its genomic DNA into a host chromosome in a site-specifi c manner. The phage genome-encoded integrase is a site-specifi c recombinase that catalyzes the recombination between two attachment sites on the phage genome (attP) and bacterial chromosome (attB), resulting in the complete integration of the phage genome (Champbell, 1962, 1992). Consequently, the integrated phage DNA is sandwiched between hybrid attachment sites, attL and attR. This prophage genome can be released from the bacterial chromosome by the action of an excisionase, which is an accessory phage-encoded protein that stimulates site-specifi c recombination between attL and attR sites. There are two major families of phage-encoded sitespecifi c recombinases, based on their conserved amino acid sequences. One of them is the tyrosine recomJ. Gen. Appl. Microbiol. , 57, 45‒57 (2011)
NOTES AND CORRESPONDENCE Satellite-Derived Vegetation Index and Evapotranspiration Estimated by Using Assimilated Atmospheric Data over Asia By Rikie Suzukil

The evapotranspiration (ET), which was estimated from assimilated atmospheric data European Centre Weather Forecasts (ECMWF) and gridded global precipitation data introduced by Xie and Arkin, was examined in relation to the vegetation activity for 1987 and 1988 over Asia. The vegetation activity was represented by the Normalized Difference Vegetation Index (NDVI) that was calculated from satellite observation. Over Siberia, the annual marches of the ET and the NDVI were quite similar. Furthermore, bimodal annual variations of the NDVI and ET were observed in Punjab (around Pakistan and northern India) where bi-seasonal cultivation is seen. The ET-NDVI relationships were analyzed for seven vegetational cover types and revealed that slopes of ET-NDVI regression lines are distinguished depending on the vegetation types. The results presented in this paper demonstrate the possibility of investigating the continental-scale vegetation activity and the ET, which is derived from assimilated gridded global data.
Developers’ Diverging Perceptions of Productivity

: To overcome the ever-growing demand for software, software development organizations strive to enhance the productivity of their developers. But what does productivity mean in the context of software development? A substantial amount of work on developer productivity has been undertaken over the past four decades. The majority of this work considered productivity from a top-down perspective (the manager view) in terms of the artifacts and code created per unit of time. Common examples of such productivity measures are the lines of source code modified per hour, the resolution time for modification requests, or function points created per month. These productivity measures focus on a single, output-oriented factor for quantifying productivity, and do not take into account developers’ individual work roles, practices and other factors that might affect their productivity, such as work fragmentation, the tools used
HEART RATE VARIABILITYMEASUREMENT USING A SMARTPHONE CAMERA

In this article authors conduct a research targeting a possibilities of heart rate variability (HRV) measurement using smartphone camera. Factors strongly influencing the photoplethysmogram signal registered with smartphone camera are described. An algorithm for HRV signal measurement using photoplethysmogram is proposed. In order to perform simultaneous photoplethysmogram and electrocardiogram registration an experiment has been settled. Comparative analysis between HRV signals measured from photoplethysmogram and electrocardiogram is performed. Relying on such analysis quantitative estimates of quality of HRV signal measured from photoplethysmogram have been acquired. Demonstrated that proposed method has high accuracy. Results of this research will be used while developing an application that is capable of processing HRV signals in real time mode.
AN ABSTRACT OF THE THESIS OF Aly Mohamed for the degree of Honors Baccalaureate of Science in Bioresource

approved:_____________________________________________________ John B. Hays The highly conserved multi-protein mismatch repair (MMR) system is known for its ability to correct post replication errors in genomic DNA. A hallmark of MMR deficiency in all organisms is microsatellite instability. The initiating proteins in the eukaryotic MMR system are hetrodimers formed with an integral MSH2 subunit and one of three other subunits; MSH3, MSH6, or MSH7. Conserved helix-turn-helix and ATPase domains in the MSH2 protein have been identified as necessary for MMR function. Mutations in these domains, followed by over-expression of the mutant proteins, have resulted in dominant-negative phenotypes in Saccharomyces cerevisiae. Described here is a project in which Arabidopsis AtMSH2 proteins carrying mutations in their helix-turnhelix and ATPase domain were constructed in “super expression” vectors then transformed into Arabidopsis thaliana with the prospect of out-competing wild-type AtMSH2 produced by the plant for hetrodimeric association with MSH3, MSH6, or MSH7. An incapacitated MMR system causes increased post-replicative mutational accumulation in cells, which can be observed through microsatellite instability. Determining the capacity of the MMR system following transformation and overexpression of the mutant AtMSH2 gene constructs is completed through detection of allele shifts in microsatellite sequences by capillary gel electrophoresis.
An Experimental Study on Model Reference Adaptive Control of TRMS by Error-Modified Fractional Order MIT Rule

Model Reference Adaptive Control (MRAC) strategies find application in flight control because of changes in dynamics of flight conditions. This paper demonstrates an application of Fractional Order Adjustment Rule MRAC (FOAR-MRAC) with the modification of model error dead zone for adaptive control of Twin Rotor Multi-input multi-output System (TRMS). Here, we implement FOARMRAC structure with feedforward and feedback MIT rules by using a fractional order integrator. Previously, Vinagre et al. have reported that MIT with fractional order integrator can improve tracking performance of MRAC. In the current experimental study, we modified model approximation error by using a piecewise linear, near-zero dead zone function and manage stability of adaptation process in practical application. Accordingly, when the control system response approximates to response of reference model, adaptation process is interrupted. This modification improves quasi-stabilization of updating rule by omitting low level errors and contributes to applicability of MRAC in real applications. An adaptive PID rotor control system is developed by integrating the proposed FOAR-MRAC structure. Simulation and experimental results, obtained for TRMS setup, are presented to show effectiveness of the proposed method.
The annotation of the switchboard corpus with the new ISO standard for dialogue act analysis

This paper is the description of a semantic annotation project that aims at the re-annotation of the Switchboard Corpus, previously annotated with the SWBD-DAMSL scheme, according to a new international standard for dialogue act analysis. A major objective is to evaluate, empirically, the applicability of the new ISO standard through the construction of an interoperable language resource that will eventually help evaluate the pros and cons of different annotation schemes. In this paper, we shall provide an account of the various aspects of the annotation project, especially in terms of the conversion between the two analytical systems, including those that can be fully automated and those that have to be manually inspected and validated. A second objective is to provide some basic descriptive statistics about the newly annotated corpus with a view to characterize the new annotation scheme in comparison with the SWBD-DAMSL scheme.
Design of on board calibration algorithms of satellite magnetometer based on two stage Centered Solution and Kalman filter methods

: Magnetometer is one of the most important sensors used in the satellite attitude determination and control system. Due to occurrence of various errors when the satellite is separated from the launcher and also during its rotation in the orbit, it is necessary to re-adjust onboard the sensor parameters. For this purpose, some solutions are proposed in this paper in which the satellite current attitude is not required. In this regard, first a magnetometer model is presented that despite conventional models; it includes nonlinearity, hysteresis and data quantization effects, permeability and installation error. Then, for sensor onboard calibration purposes, two stages-offline and two-stage online series structures are suggested. In the offline case, the centered solution and Levenberg Marquardt methods have solution method has lower computational load and shorter time convergence, but it has lower accuracy with respect to online methodology.
Show Me The Rules! A User Study On Making Data Validation Rules Explicit in Spreadsheet Applications

Spreadsheet applications have become one of the most popular end-user programming environments with innumerous built-in facilities, including arithmetic, financial and statistical operations. Not surprisingly, spreadsheet applications play significant role in decision-making processes in organizations, thus making spreadsheet errors serious threats. Reports from field audits show that spreadsheet errors may cause companies to lose millions of dollars annually. One effective and simple way of helping users to avoid introducing mistakes in their spreadsheets is data validation. Indeed, most spreadsheet applications provide a wide range of built-in functions to restrict the type of the input data or the range of valid values entered into a cell. However, in most of them, the underlying design decisions governing how data input should be entered in a spreadsheet are not explicitly visible to its users. Hiding data validation rules from users may hinder the comprehensibility and the usability of a spreadsheet, thus increasing the risks of entering incorrect data input. To assist end-user programmers in explicitly expressing validation rules in spreadsheets, we propose the SpreadSheet Validation Language (SSVL). We conducted a user study to assess the effectiveness of SSVL. The results show that users using SSVL are faster and more productive in tasks involving the comprehension of data validation rules. This is a promising result suggesting that SSVL can actually improve the usability of spreadsheets.
6-Aptamer-based and immunosorbents

To face the analysis of compounds that may be present at very low levels of concentration in complex media, such as food, environmental and biological fluids, it is possible to exploit the affinity and specificity of antibodies for their antigen by immobilizing them on a solid support. The resulting immunosorbents allow an effective extraction of compounds of interest while eliminating the other components of the matrix. The objective is then to make the analysis more reliable in terms of quantifying target analytes by eliminating matrix effects. A similar potential can also be obtained using aptamers, i.e. DNA or RNA sequences with high specificity towards compounds. The objective of this chapter is to present the respective characteristics of immunosorbents and aptamer-based sorbents, also known as oligosorbents, and their potential for the selective extraction of targeted compounds for the treatment of real samples.
Investigation of a new hot stamping process with improved formability and productivity

In order to improve the drawability of boron steel and also to increase the productivity of hot stamping process, a new hot stamping process with pre-cooling has been proposed. Stress-strain behavior at various temperatures was investigated and compared with that in traditional hot stamping processes. Detailed studies were carried out on the strain hardening parameter, n, at different temperatures and deformation rates. To evaluate this concept, hot stamping experiments were performed with both conventional (without pre-cooling) and new process (with pre-cooling) for a scaled down B-Pillar automotive component. The new hot stamping process with pre-cooling was able to produce the B-Pillar at low temperature (500 °C) with less thinning than the hot stamping carried out without precooling at high temperature (765 °C). Also the in-die quenching time was reduced by about 60%, by adopting the new hot stamping process with pre-cooling, which would increase the productivity significantly for automotive mass production without compromising the part quality.
J. Gen. Appl. Microbiol., 53, 229–237 (2007)

The waterborne pathogen Vibrio cholerae is the causative agent of epidemics of cholera in many developing countries including Thailand (Dalsgaard et al., 1999; Shears, 2001). The two serogroups associated with cholera are V. cholerae O1 and O139 (Faruque et al., 2003; Huq et al., 1995). Although routine isolation from water is not achieved by the conventional culture method, V. cholerae is present in natural aquatic environments (Colwell and Huq, 1994) and the role of water in the transmission of V. cholerae is well established (Colwell, 1993, 2000; Islam et al., 1993a, 1994a). The toxigenic V. cholerae serovars O1 and Application of duplex-PCR in rapid and reliable detection of toxigenic Vibrio cholerae in water samples in Thailand
Journal of Social Ontology

This paper introduces freely improvised joint actions, a class of joint actions characterized by (i) highly unspecific goals and (ii) the unavailability of shared plans. For example, walking together just for the sake of walking together with no specific destination or path inmind provides an ordinary example of FIJAs, alongwith examples in the arts, e.g., collective free improvisation inmusic, improv theater, or contact improvisation in dance. We argue that classic philosophical accounts of joint action such as Bratman’s rule them out because the latter require a capacity for planning that is idle in the case of FIJAs. This argument is structurally similar to arguments for minimalist accounts of joint action (e.g., based on joint actions performed by children before they develop a full-fledged theory of mind), and this invites a parallel minimalist account, which we provide in terms of a specific kind of shared intentions that do not require plan states. We further argue that the resulting minimalist account is different in kind from the sort of minimalism suggested by developmental considerations and conclude in favor of a pluralisticminimalism, according towhich there are several ways for an account of joint action to be minimal.