Miracle-dz/UniFAR-FTUs huggingface dataset:
Valproic acid restores the down-regulation of SDF-1 following kidney ischemia; experimental validation of a mathematical prediction

Background and purpose: Stromal-derived factor (SDF)-1, a chemokine recruiting leucocytes and stem cells, plays an essential role in tissue regeneration. In aprevious study, we have unexpectedly found that the expression of this chemokine declines following kidney ischemia reperfusion (IR). To explain this observation, a mathematical model was constructed which proposed histone deacetylase (HDAC) as the main driver of SDF-1 down-regulation. To experimentally verify this prediction, the effect of valproic acid (VPA), a potent HDAC inhibitor, on the kinetics of kidney SDF-1 expression was here assessed. Experimental approach: Adult mice were subjected to IR or sham operation and received VPA or vehicle. Next, SDF-1 expression as well as tissue repair indices were measured in a time course manner. Findings / Results: The transcriptional expressions of Sdf-1 alpha, beta, and gamma isoforms were noisy in the sham groups but the fluctuations disappeared following IR where a continuous declining trend was observed. VPA induced the over-expression of gamma, but not alpha and beta mRNA in IR mice which was accompanied with protein upregulation. Remarkably, VPA deteriorated kidney injury. Conclusion and implications: HDAC inhibition restores SDF-1 down-regulation following kidney IR. The present study is a classic example of the potential of computational modeling for the prediction of biomedical phenomena.
Integrated SolidWorks and Simscape platform for the design and control of an inverted pendulum system

Abstract A single inverted pendulum on a cart (SIPC) is designed and modeled physically using SolidWorks. The model is then exported to the Simulink environment to form a Simscape model for simulation and test purposes. This type of modeling uses a physical grid tactic to model mechanical structures. It requires connection of the physical elements with physical signal converter to define the implicit system dynamics to be modeled. The integration between the SolidWorks and Simscape eliminates the need of deriving the mathematical model and provides a platform for the rapid controller design for the system. State feedback control scheme is proposed, designed, and tuned aiming to maintain the pendulum in the upright place while tracking the desired cart position. Several simulation cases are studied to prove the controller abilities. In order to examine the controller robustness, disturbance rejection and noise attenuation capabilities are also discovered.
Multi-drug resistant mesophilic aeromonads isolated from marketed scallops (Patinopecten yessoensis) harboring resistance genes

Abstract Antimicrobial resistance properties of 32 Aeromonas strains isolated from fresh scallops (Patinopecten yessoensis (Jay)) marketed in Korea were assessed. All the Aeromonas spp. , including A. salmonicida, were mesophilic and grew very well at 37°C. The isolates were tested for susceptibility to 19 antimicrobials belonging to eight antimicrobial classes. All isolates were multi-drug resistant, which means they were resistant to five or more antimicrobials. Higher resistance rates (≥ 50%) were observed for ampicillin, piperacillin, cephalothin, imipenem, meropenem, trimethoprim-sulfamethoxazole, tetracycline, oxytetracycline, and nalidixic acid while intermediate resistance was also determined. PCR assays revealed the presence of many antimicrobial resistance genes among the isolates in varying combinations. Among them, some isolates harbored higher numbers of resistant genes, e.g., A. veronii-V1 (aac(6’)-Ib, tetE, qnrS, IntI1), A. salmonicida–SL10 (IntI1, blaCTX, aac(3’)-Ib, aac(6’)-Ib, qnrS), A. hydrophila–H13 (IntI1, blaTEM, qnrS, aac(6’)-Ib, strA-strB). However, neither the blaSHV, blaIMP, tetB, qnrA, qnrB, and aphAI-IAB genes nor class1 integrons were detected in any of the isolates. Discrepancies between phenotypic and genetic resistance traits were observed in some isolates. With respect to outcomes, scallops are proposed as a source of multi-drug resistant Aeromonas spp. that harbor antimicrobial resistant genes.
Indexed Mental Files and Names in Fiction

Abstract In this paper, I argue that the theory of mental files can provide a unitary cognitive account of how names and singular terms work in fiction. I will suggest that the crucial notion we need is not the one of regular file, i.e., a file whose function is to accumulate information that we take to be about a single object of the outside world, but the notion of indexed file, i.e., a file that stands, in the subject’s mind, for another subject’s file about an object. When we read a novel containing the name of an individual, we acquire (fictional) information about that individual and we store those pieces of information into an indexed file. If the name also refers to a real individual outside the context of fiction, the indexed file is linked with the pre-existing regular file that we have about such individual. Otherwise, the indexed file is linked to a regular file referring to an abstract object, namely the fictional entity itself.
Pivotal Advance: α‐Galactosylceramide induces protection against lipopolysaccharide‐induced shock

α−galactosylceramide, a natural killer T cell ligand, and its synthetic homolog, KRN7000, consistently influence IFN‐γ and TNF‐α release, both mediators of LPS‐induced shock. To modify the course of endotoxin shock, we injected KRN7000 at different time points of experimental systemic Shwartzman reaction. Mice treated with KRN7000 survived when it was injected within 2 h before and after LPS challenge. Mice survival was associated with low levels of T helper 1 (Th1) cytokines, such as IFN‐γ and TNF‐α. By contrast, protection from endotoxin shock was associated with an increase of T helper 2 (Th2) cytokines, like IL‐4 and IL‐10. A role of Th2 cytokines in counteracting LPS‐induced shock was supported by experiments in which the protection against Shwartzman reaction by KRN7000 was abrogated by in vivo coadministration of anti‐Th2 cytokines antibodies. In addition, cytofluorimetric analysis showed that surviving animals have higher percentages of NKT‐IL‐10‐positive cells and lower percentages of NKT‐IFN‐γ and macrophages/TNF‐α‐stained cells than nonprotected mice. Taken together, our data demonstrate that KRN7000 treatment given at times near LPS challenge is protective for endotoxin shock inhibiting IFN‐γ and TNF‐α release. Moreover, KRN7000‐mediated protection occurs through an increased production of IL‐4 and IL‐10, which are mainly secreted by NKT cells. Since IFN‐γ release by NKT requires a longer TCR stimulation than that required for Th2 cytokines production, we demonstrate that timing of KRN7000 in vivo exposure affect the pattern of cytokines expression protecting animals by endotoxin shock.
Stochastic electrical energy management of industrial Virtual Power Plant considering time-based and incentive-based Demand Response programs option in contingency condition

Abstract Nowadays, the sustainable energy management of industrial environments is of great importance because of their heavy loads and behaviors. In this paper, the Virtual Power Plant (VPP) idea is commented as a collected generation to be an appropriate approach for these networks handling. Here, Technical Industrial VPP (TIVPP) is characterized as a dispatching unit contains demands and generations situated in an industrial network. A complete structure is proposed here for possible conditions for different VPPs cooperation in the power market. This structure carries out a day-ahead and intra-day generation planning by choosing the best Demand Response (DR) programs considering wind power and market prices as the uncertain parameters. A risk management study is likewise taken into account in the proposed stages for contingency conditions. So, some component changes, like, regular demand changes and single-line outage are prepared in the framework to authorize the suggested concept in the contingency situation. To determine the adequacy and productivity of the proposed strategy, the IEEE-RTS modified framework is examined to test the technique and to evaluate some reassuring perspectives too. By the proposed methodology, the delectability of DR projects is uncovered in industrial networks and the improvement level of load shedding and the lower cost will be achieved.
Effect of substituting fine rutile of the flux with nano TiO2 on the improvement of mass transfer efficiency and the reduction of welding fumes in the stainless steel SMAW electrode

This paper presents a novel method for reducing fume formation rate (FFR) and hexavalent chromium (Cr(VI)) concentration in welding fumes by substituting fine rutile in the flux of SMAW electrode with nano TiO2. A maximum reduction of FFR up to 21% and Cr(VI) up to 42% was achieved in the experimental electrode. For the first time, the experimental study related the efficacy of mass transfer of specific elements to their percentage reduction in the emission. The results of the constituent analysis showed that Fe, Ni, Cr and Mn in the welding fumes were reduced up to 16%, 44%, 32% and 28% respectively due to the deoxidization property of the nano-Ti, which prevented the target elements to get oxidized.
Woodpecker Abundance and Habitat Use in Mature Balsam Fir Forests in Newfoundland

Availability of the oldest age-class of balsam fir (Abies balsamea) forest, the major forest type of western Newfoundland, is declining through logging, insect effects, and management for a 60-year harvest rotation. Loss of old-growth balsam fir forests may limit the availability of woodpecker habitat if nesting trees and feeding substrates are most abundant in these later successional stages. We assessed abundance of black-backed woodpeckers (Picoides arcticus), downy woodpeckers (P. pubescens), and hairy woodpeckers (P. villosus) in 10 stands in each of 3 forest age classes (40-59, 60-79, and >80 yr) of balsam fir in western Newfoundland. For each stand, we quantified 10 habitat variables that may have influenced habitat use by woodpeckers. Black-backed woodpeckers were almost exclusively found in >80-year-old forests. Density of black-backed wood-peckers was significantly related to number of large snags, but negatively to the total number of dead stems. Downy woodpeckers were common and similarly distributed among the 3 forest age classes, and hairy wood-peckers were uncommon and only observed in the 40- and 60-year age classes. Downy and hairy woodpeckers were significantly associated with the number of white birch snags in the stands, a resource that declined with forest age. A reduction in the amount of forest in the oldest age class is probably reducing the population of black-backed woodpeckers in western Newfoundland. We recommend a series of fixed-width transects, coupled with point counts using call broadcasts, as an effective means of surveying woodpeckers. Forest managers must maintain large areas of old forests, temporally and spatially, to maintain black-backed woodpeckers in Newfoundland.
Genotype-specific requirements for in vitro culture initiation and multiplication of Magnolia taxa

Abstract The influence of basal media composition, concentration of plant growth regulators (PGRs), and the developmental stage of primary explants (dormancy, stage of bud opening and fruit ripening) on the initiation phase of nine Magnolia genotypes, including M. stellata /Sieb. & Zucc. /Maxim. , M. × soulangeana ‘Rustica Rubra’, M. denudata Desr. , M. × soulangeana ‘Alexandrina’, M. liliiflora Desr. , M. officinalis var. biloba Rehd. & Wils. , M. salicifolia Maxim. , M. × soulangeana ‘Lennei’, and M. kobus DC, was evaluated. The highest efficiency of primary culture initiation of seven Magnolia genotypes (except for M. liliiflora and M. salicifolia) was achieved from primary explants collected in the bud opening stage. A high positive correlation was found between total tannins and efficiency of the primary culture initiation at the fruit ripening stage (r = 0.833). Standardi and Catalano medium (S2) with 0.5 mg l−1 of 6-benzylaminopurine (BAP) was the most appropriate for multiplication of M. × soulangeana ‘Alexandrina’, whereas tissue cultures of M. × soulangeana ‘Lennei’ proliferated and grew better on S2 medium with 1.0 mg l−1 of BAP and 1.0 g l−1 of polyvinylpyrrolidone. The requirements for the composition of basal media and concentration of PGRs in the initiation and multiplication stages of micropropagation of various Magnolia species and cultivars are genotype-specific.
The LOFAR Long-Baseline Calibrator Survey Classification

Abstract Data manipulation of the LOFAR Long-Baseline Calibrator Survey (LBCS) and the Westerbork Northern Sky Survey (WENSS) catalogues are carried out in the present study. The aim of the study is to make calibrator classification statistics plots and estimations for further observations and upcoming stations. First, mean flux densities of LBCS calibrators against declination and observed station baseline length to the tied core station are plotted and the classified sources are marked. Second, we provide the designation – naming it the success rate – for the number of sources with the correlated signal against all the LBCS catalogue sources. Third, there is a trend in mean peak flux densities between stations – longer the baseline, higher mean peak flux density. Finally, estimations for upcoming and recent stations are made and some results are not encouraging.
WiROS: A QoS Software Solution for ros2 in a WiFi Network

Robot Operating System (ROS) has played a pivotal role as a communication middleware among different peripherals, including sensors and actuators of robotics and other systems, with the advancement of connected systems around the globe. The development of DDS (Data Distribution System) based ROS2 has also increased its popularity for applications involving multi-bot communication over the network. However, latency and throughput become bottlenecks for latency-critical applications such as remote surgery and remote driving in dense data traffic. ROS2-based end systems identify the data flow of their sensors' & actuators' messages as topics. A middleware solution must be designed to ensure the QoS (Quality of Service) required by the topics associated with the latency-critical applications. We perform a comparative study of the target application's topic affected by other existing topics in the network. A software solution to ensure the desired QoS to the applications in a static traffic scenario has been developed based on the scheduling of the message data flow and WiFi's EDCA parameters' configurations.
Strict anaerobic organisms resembling Wolinella isolated from human gingival crevice

The existence of gram negative asaccharolytic rod-shaped bacteria in the human oral cavity has been reported by a number of investigators. However, the data on motile anaerobic bacteria are considered to be less numerous. Van Palenstein Heldermanl) isolated hydrogen dependent organisms resembling Vibrio succinogenes which had been previously reported by Wolin et al.2) Recently, Tanner et al. isolated anerobic gram negative asaccharolytic bacteria with a polar flagellum from the human dental plaque and proposed a new genus Wolinella31. We also isolated strict anaerobic gram negative, motile, asaccharolytic rods from the human gingival crevice area. They were similar, in some biochemical characters, to the organisms reported by Van Palenstein Helderman and Rosman and Wolinella, but were distinct from them, especially in their morphological characters. In this communication, the morphology and some biochemical characteristics of the newly isolated organisms are reported and discussed. Fourteen strains of bacteria were isolated from the clinical healthy gingival crevice of man in a modified CBRCA medium described by Van Palensterin and Winkler4) in an anaerobic glove box (Anaerobox, Hirasawa, Tokyo) under a gaseous atmosphere of N2:H2: CO2 = 80:10: 10. They were purified in a RCA medium (Oxoid), and maintained in the RCA medium or in a BHI agar medium (Difco). The morphological characteristics of the
Estimativas volumétricas em povoamentos de eucalipto sob regime de alto fuste e talhadia no sudoeste da Bahia

Esse estudo teve como objetivo testar modelos volumetricos e avaliar a eficiencia de tres metodos para estimar o volume de madeira em plantios de Eucalyptus urophylla, manejados sob regime de alto fuste e talhadia no Municipio de Vitoria da Conquista, BA. Foi realizada cubagem rigorosa de arvores para obtencao do volume individual, e com os dados foram ajustados sete modelos volumetricos. Os melhores modelos foram selecionados com base no criterio de selecao do valor ponderado dos escores dos parâmetros estatisticos (VP). Os volumes obtidos por meio dos tres metodos (fator de forma, quociente de forma e modelos ajustados) foram comparados ao volume obtido na cubagem. O modelo de Schumacher e Hall logaritmizado e de Spurr foram os mais indicados para estimar o volume dos povoamentos nas duas condicoes de manejo. O volume obtido a partir dos dois melhores modelos ajustados resultou em estimativas mais proximas do volume real quando comparados aos volumes estimados pelo fator de forma e quociente de forma. doi: 10.4336/2011.pfb. 31.68. 309
trategies for simultaneous detection of multiple plant viruses

Plants are infected by a wide range of viruses. Many cause devastation of plants and crops resulting in significant economic losses and threats to the viability of certain horticultural and agricultural industries. Resources available for routine detection of plant viruses tend to be limited. This means that techniques adopted for routine diagnosis must be of low cost yet sensitive and reliable. Approaches that allow simultaneous detection of multiple plant viruses (multiplexing) reduce the number of tests required, reagent usage, time for analysis, and consequently, the cost. Multiplex polymerase chain reaction (PCR), polyvalent PCR, nonisotopic molecular hybridization techniques, real-time PCR, and array technologies allow simultaneous detection of multiple plant viruses. The increased sensitivity achieved with some techniques, such as real-time PCR, permits the use of simple, low-cost target isolation methods such as direct binding, tissue printing, or immunocapture. These result in reduced overall cost. Multiplexing techniques have the capacity for simultaneous broad-spectrum and specific identification by combining primers and (or) probes that target various taxonomic levels such as family, genus, and species. Polyvalent PCR and broad-spectrum probes have the potential to detect unknown or uncharacterized viruses, improving our ability to monitor and successfully control these pathogens. Techniques such as microarray analysis offer the potential for development of a single biochip that may facilitate detection of all viruses affecting a particular crop (e.g., a cucurbit or potato biochip). This may be expanded in time to the detection of every pathogen, including viruses, affecting a particular plant.
Clearing the Mud from the Conservation Opportunity Debate: Reply to Pressey and Bottrill

We are delighted that Pressey and Bottrill (2008) agreewith the message conveyed in Knight and Cowling(2007), namely, that the effectiveness of conservation-planning initiatives can be greatly improved when op-portunities for and constraints on implementing conser-vation action are explicitly incorporated into the identi-fication of spatial priorities. Pressey and Bottrill (2008),however, contend we “muddied the water” on the op-portunism debate by (1) discounting the contributionsto real-world conservation of researchers pursuing quan-tifiable certainty at the expense of useful outputs anddistinguishing these researchers from those engaged inpragmatic real-world conservation planning, (2) statingthat incorporation of measures of threat in spatial pri-oritizations “unnecessarily emphasizes obstacles to con-servation action or ‘shackles conservation planning witha negative perspective’,” and (3) conflating 2 differentmeanings of the term
Plasmonic nanostructures of SnO2:Sb thin film under gamma radiation response

Abstract This paper is a part of a natural dye solar cell project. Conductive transparent oxide (CTO) films have been deposited onto preheated glass substrates using a spray pyrolysis technique. The optical, electrical, structural properties as well as thermal annealing and gamma radiation response were studied. The average optical energy gap of doped films for direct allowed and direct forbidden transitions were found to be 3.92 and 3.68 eV, respectively. The plasmon frequency and plasmon energy after doping were found to be 3.48 × 1014 s −1 and 0.23 eV. The negative absorbance of the doped film was observed in UV-Vis range after applying both thermal annealing and γ-dose irradiation with 22 kGy. The negative refractive index of the doped film in UV range (220 – 300 nm) is promising for optical applications. The electron mobility μe reached a maximum of 27.4 cm2 V−1 s−1 for Sb concentration of 10 %. The corresponding resistivity ρ, and sheet resistance Rs reached their minimum values of 1.1 × 10−3 Ω cm and 35 Ω sq−1, respectively. The dopant concentration has been increased from 4.13 × 1019 to 2.1 × 1020cm−3. The doped film was found to exhibit three diffraction peaks associated with (2 2 2), (2 0 0), and (2 1 1) reflection planes, of which the peak of (2 2 2) of Sb2O3 and the peak of (2 0 0) were very close.
Intracellular misrouting and abnormal secretion of adrenocorticotropin and growth hormone in Cpefat mice associated with a carboxypeptidase E mutation

Cpefat mice carry a mutation in the carboxypeptidase E/H gene which encodes an exopeptidase that removes C-terminal basic residues from endoproteolytically cleaved hormone intermediates. These mice have endocrine disorders including obesity, infertility, and hyperproinsulinemia–diabetes syndrome, but the etiology remains an enigma. Because studies have identified membrane carboxypeptidase E as a sorting receptor for targeting prohormones to the regulated secretory pathway for processing and secretion, the intracellular routing and secretion of pro-opiomelanocortin/adrenocorticotropin and growth hormone from anterior pituitary cells were investigated in Cpefat mice. In Cpefat mice, pro-opiomelanocortin was accumulated 24-fold above normal animals in the pituitary and it was poorly processed to adrenocorticotropin. Furthermore, pro-opiomelanocortin was secreted constitutively at high levels, showing no response to stimulation by corticotropin-releasing hormone. Similarly, growth hormone release was constitutive and did not respond to high K+ stimulation. Both pro-opiomelanocortin and growth hormone levels were elevated in the circulation of Cpefat mice versus normal mice. These data provide evidence that the lack of carboxypeptidase E, the sorting receptor, results in the intracellular misrouting and secretion of pro-opiomelanocortin and growth hormone via the constitutive pathway in the pituitary of Cpefat mice.
Glutamate Receptors : Emerging Links Between Subunit Proteins and Specific Excitatory Circuits in Primate Hippocampus and Neocortex

an indispensable role in brain function. Recent molecular advances have revealed an increasingly elaborate panel of GluR subunits that combine to form a variety of heteromeric GluR complexes with distinct functional characteristics determined by the stoichiometry of the subunit composition. Excitatory circuits in hippocampus and neocortex exhibit a complex and highly ordered array of termination patterns that reflect both