Miracle-dz/UniFAR-FTUs huggingface dataset:
Development of an EEG signal processing program based on EEGLAB

Brain Computer Interface development requires different disciplines from the engineering area. The amounts of information generated by a project like this are huge and need to be processed with the assistance of specialized software. EEGLAB is software that allows signal processing with graphing capabilities regardless the dataset amount. EEGLAB is open source, multiplatform and with a user friendly interface that allows inexperienced users to be able to use the software. This open source software is useful as a reference point for the development of a LabView based program.
A Parametric Model Approach for Structural Reconstruction of Scale-Free Networks

We propose a parametric network generation model which we call network reconstruction model (NRM) for structural reconstruction of scale-free real networks with power-law exponent greater than 2 in the tail of its degree distribution. The reconstruction method for a real network is concerned with finding the optimal values of the model parameters by utilizing the power-law exponents of model network and the real network. The method is validated for certain real world networks. The usefulness of NRM in order to solve structural reconstruction problem is demonstrated by comparing its performance with some existing popular network generative models. We show that NRM can generate networks which follow edge-densification and densification power-law when the model parameters satisfy an inequality. Computable expressions of the expected number of triangles and expected diameter are obtained for model networks generated by NRM. Finally, we numerically establish that NRM can generate networks with shrinking diameter and modular structure when specific model parameters are chosen.
Homocysteine impaired endothelial function through compromised vascular endothelial growth factor/Akt/endothelial nitric oxide synthase signalling

1. Hyperhomocysteinaemia (HHcy) is associated with endothelial dysfunction and has been recognized as a risk factor of cardiovascular disease. The present study aimed to investigate the effect of homocysteine (Hcy) on endothelial function in vivo and in vitro, and the underlying signalling pathways.
LQG/H∞ control of linear quantum stochastic systems

The purpose of this paper is to investigate an efficient coherent controller design scheme for the general mixed LQG/H∞ control problem of the linear quantum stochastic systems. To solve the specific difficulty of the physical realizability constraints, the problem is reformulated as a rank constraint LMI problem, and numerical solution can be attained by using Matlab and softwares therein.
Architectural support for detection of sleepy eye behavior

Detecting human sleep is an area of active research. At Siemens Corporate Research Inc., a method to track human eyes in a sequence of images was developed. The method is used to detect when the subject is on the verge of sleep. A key component of the methodology is a filter used to isolate the eyes. In this paper, the algorithm, architecture and implementation of this filter is presented. The implementation of the filter is based on field programmable gate arrays from Xilinx.
Management of Severe Developmental Regression in an Autistic Child with a 1q21.3 Microdeletion and Self-Injurious Blindness

We report the case of a young boy with nonverbal autism and intellectual disability, with a rare de novo 1q21.3 microdeletion. The patient had early and extreme self-injurious behaviours that led to blindness, complicated by severe developmental regression. A significant reduction in the self-injurious behaviours and the recovery of developmental dynamics were attained in a multidisciplinary neurodevelopmental inpatient unit. Improvement was obtained after managing all causes of somatic pains, using opiate blockers and stabilizing the patient's mood. We offered both sensorimotor developmental approach with therapeutic body wrap and specific psychoeducation adapted to his blindness condition for improving his communication abilities.
Visualizing Temporal Behavior in Multifield Particle Simulations

Particle-based simulations generate time-varying multifield volumetric datasets. Visualizations of such volumes traditionally focus on the physical space, displaying particles as glyphs or with volume rendering techniques. In this paper we deal specifically with the issue of helping users to observe and interpret the multidimensional feature space and its temporal behavior, as a complement to existing spatial views. Our approach combines multiple visualizations to assist analysis of time-varying data generated by particle simulations. Coordinated views of both feature and physical spaces allow the observation of particle behavior over specific time periods or the whole temporal domain, rather than describing a single simulation time step. Temporal behavior in the physical space is depicted as pathlines, whereas the temporal behavior of the underlying multidimensional feature space is depicted in a so-called streamfeature visualization. Streamfeatures are pathlines describing changes in feature space along time, obtained by projecting the feature vectors. Direct interaction with these line representations is difficult. Thus, two supporting views are supplied for user interaction, which show 2D projections of both the pathlines (pathline projection view) and the streamfeatures (streamfeature projection view), obtained by projecting geometric features extracted from the lines. By linking all visualizations, users may interact with these views to identify and select representative clusters of lines that reflect similar behavior of particle features. We use data from two particle simulations to illustrate the framework and its potential to support analysis of global temporal behavior and relationships between multiple variables.
13 Genetics of Chronic Lymphocytic Leukemia : Practical Aspects and Prognostic Significance

The disease course is heterogenous. Clinical staging systems (i.e. Rai and Binet) are used for estimating the tumor burden and prognosis and for making therapeutic decisions in individual patients. However, the evolution, even in the early stages, remains highly variable with at least 50% of cases showing early or late progression. Since the large majority of newly diagnosed cases present with early or intermediate stage, it is important to assess the risk profile within this group.
Assessment of genetic diversity on goat breeds in Malaysia using microsatellite markers.

Genetic characterisation of goat populations in Malaysia is essential for conservation strategy as well as for genetic improvement. The goat populations in Malaysia comprise the small-framed original Katjang goats and the larger framed exotic goats: the Jamnapari, Boer and Savanna. With continuous importation, these exotic breeds are slowly replacing the indigenous Katjang, which is in danger of extinction if there is no concrete plan to conserve the breed. The aim of this study was to determine the genetic diversity of goat breeds in Malaysia using microsatellite markers for proper utilisation in breeding program. Thirty microsatellite markers were used successfully to amplify caprine genomic DNA using a PCR-based technique. Low levels of number of alleles per locus were found in the Katjang, Jamnapari, Boer and Savanna breeds. The mean number of alleles per locus was 5.69. All four breeds and loci showed significant (p<0.05) deviations from HWE except for three loci. The results of the FIS determinations, together with the low number of alleles indicate the occurrence of inbreeding in all four breeds.
Development of an Ion-Pair Reverse-Phase Liquid Chromatographic/Tandem Mass Spectrometry Method for the Determination of an 18-Mer Phosphorothioate Oligonucleotide in Mouse Liver Tissue

A quantitative method for the determination of a partially modified, 2′-ribose alkoxy 18-mer phosphorothioate oligonucleotide in liver tissue has been developed. A liquid:liquid extraction, ion-pair reverse phase chromatographic separation and tandem mass spectrometry were used to achieve a quantitation range of 125 to 10,000 ng g−1 mouse liver tissue. A total cycle time of 5 min was obtained while maintaining separation of three potential impurities. Separations were performed using a Discovery RP-Amide C16, 100 × 2 mm column packed with 5 μm particles. The separation was facilitated by the use of triethylamine (TEA) and hexafluoroisopropanol (HFIP) as ion-pair agents. The method has subsequently been used for the determination of other phosphorothioate oligonucleotides in support of discovery research.
OFDMA Uplink Frequency Offset Estimation with Multi-Access Interference Mitigation

In this paper, we consider the frequency offset estimation for Orthogonal Frequency-Division Multiple Access (OF-DMA) uplink (UL) transmissions. We first analyze the negative effect of Multi-Access-Interference (MAI) on OFDMA UL, and then propose two interference reduction/elimination methods, i.e., the Reduced-Rank-Projector (RRP) and Shift-Sampling-Projector (SSP) methods, to eliminate/reduce the heavy MAI due to the frequency offsets. Finally, we propose a new training sequence group named the Round-Robin Training Sequence Group (RRTSG), which has a high interference mitigation capabilities for OFDMA UL transmission. The Cramer-Rao Lower Bound (CRLB) for an unbiased frequency offset estimator in a Multiple Access (MA) system is also derived. Numerical results show that the proposed methods are suitable to eliminate/mitigate the effect of the frequency offset on OFDMA UL transmission.
Grasp Recognition Using The Contact Web

We propose an approach to teach robots to ger- form grasping tasks. This approach is based on the Assembly Plan from Observation (APO) paradigm, where the key idea is to enable a system to observe a human performing a grasping task, understand it, and perform the task with minimal human intervention. A grasping task is composed of three phases: pre-grasp phase, static grasp phase, and manipulation phase. The first step in recognizing a grasping task is to identify the grasp itself (within the static grasp phase). We propose to identify the grasp by means of a grasp representation called the contact web which is composed of a pattern of effective contact points between the hand and the object. We also propose a grasp taxonomy based on the contact web to systematically identify a grasp. Results from grasping experiments show that it is possi- ble to distinguish between various types of grasps using the proposed contact web and grasp taxonomy.
A Pyramid of Concentric Circular Regions to Improve Rotation Invariance in Bag-of-Words Approach for Object Categorization

The bag-of-words (BoW) approach has shown to be effective in image categorization. Spatial pyramids in conjunction to the original BoW approach improve overall performance in the categorization process. This work proposes a new way of partitioning an image in concentric circular regions and calculating histograms of codewords for each circular region. The histogram of the entire image is concatenated forming the image descriptor. This slight and simple modification preserves the performance of the original spatial information and adds robustness to image rotation. The pyramid of concentric circular regions showed to be almost 78% more robust to rotation of images in our tests compared to the traditional rectangular spatial pyramids.
RENAL DYSPLASIA IN BARDETBIEDL BARDETBIEDL BARDETBIEDL SYNDROME

Background: Bardet-Biedl syndrome (BBS) is a multisystem genetic disorder characterized with central obesity, pigmentary retinopathy, polydactyly, mental retardation, and hypogenitalism. Renal abnormalities have been recognized as a cardinal feature of the disease with serious prognostic implication. The aim of this study was to analyze the renal status in children with BBS and to implement appropriate interventions in those with progressive course Patients and methods: The diagnosis of BBS was established on the basis of criteria proposed by Beales et al. (J Med Genet 1999). Imaging of the kidneys and urinary tract was performed with ultrasound study, Tc99 m DMSA scan and a cystographic study. Twenty four hour urine collections were obtained for estimation of proteinuria and creatinine clearance. Blood pressure was monitored at clinical visits or as 24-hour ambulatory monitoring. Results: There were 4 children (2 males, 2 females). All four children displayed abnormal kidney ultrasound and Tc99 m DMSA scan resembling dysplastic kidney(s). Two of them had overt proteinuria (glomerulo-tubular pattern). Three children had normal blood pressure and glomerular filtration rate (GFR): 107, 145 and 95 ml/min/1.73m 2 , and the fourth had hypertension and progressive worsening of the GFR at 65 ml/min/1.73m 2 . Conclusion: Children with BBS should undergo imaging studies of the kidneys and urinary tract at initial work up; in those with renal dysplasia proteinuria, GFR and blood pressure should be regularly monitored to slow down progression to terminal renal failure.
even-Year Follow-Up fter Dobutamine Stress Echocardiography mpact of Gender on Prognosis

OBJECTIVES The aim of this study was to investigate the effects of gender on long-term prognosis of patients undergoing dobutamine stress echocardiography (DSE). BACKGROUND Gender differences in the predictors of outcome among patients with known or suspected coronary artery disease undergoing DSE have not been adequately studied. METHODS We studied 2,276 men and 1,105 women with known or suspected coronary artery disease who underwent DSE. Follow-up events were cardiac death and nonfatal myocardial infarction (MI). RESULTS Dobutamine stress echocardiography was normal in 687 men (30%) and 483 women (44%) (p 0.0001). Ischemia on DSE was present in 1,194 men (52%) and 416 women (38%) (p 0.001). During a mean follow-up of 7 3.4 years, there were 894 (26%) deaths (442 attributed to cardiac causes) and 145 (4%) nonfatal MIs. The annual cardiac event rate was 2.5% in men and 1.2% in women with normal DSE. Independent predictors of cardiac events in patients with normal DSE using a Cox proportional hazards regression analysis were male gender (hazard ratio [HR]: 1.7 [range 1.1 to 2.8]), age (HR: 1.02 [range 1.01 to 1.04]), history of heart failure (HR: 3.4 [range 1.5 to 7.9]), previous MI (HR: 1.7 [range 1.1 to 2.8]), and diabetes (HR: 2.4 [range 1.3 to 4.5]). Independent predictors of cardiac events in patients with an abnormal DSE were age (HR: 1.03 [range 1.02 to 1.04]), history of heart failure (HR: 1.7 [range 1.3 to 2.1]), diabetes (HR: 1.4 [range 1.1 to 1.8]), heart rate at rest (HR: 2.8 [range 1.4 to 5.8]), wall motion abnormalities at rest (HR: 1.06 [range 1.04 to 1.09]), and ischemia on DSE (HR: 1.04 [range 1.02 to 1.07]). Myocardial ischemia was an independent predictor of cardiac events in both men and women. CONCLUSIONS Dobutamine stress echocardiography provides independent prognostic information in both men and women. In patients with normal DSE, gender is independently associated with cardiac events. The outcome of patients with abnormal DSE is not related to gender, after adjusting for stress echocardiographic abnormalities. (J Am Coll Cardiol 2005;45:93–7) ublished by Elsevier Inc. doi:10.1016/j.jacc. 2004.09. 048
Identification of CHD7S as a novel splicing variant of CHD7 with functions similar and antagonistic to those of the full‐length CHD7L

CHD7 is one of the nine members of the chromodomain helicase DNA‐binding family of ATP‐dependent chromatin remodeling enzymes. Mutations in CHD7 give rise to CHARGE syndrome, a human condition characterized by malformation of various organs. We have now identified a novel transcript of CHD7 that is generated by alternative splicing of exon 6. The protein encoded by this variant transcript (termed CHD7S) lacks one of the two chromodomains as well as the helicase/ATPase domain, DNA‐binding domain and BRK domains of the full‐length protein (CHD7L). CHD7S was found to localize specifically to the nucleolus in a manner dependent on a nucleolar localization signal. Over‐expression of CHD7S, as well as that of CHD7L, resulted in an increase in 45S precursor rRNA production. Conversely, depletion of both CHD7S and CHD7L by RNA interference inhibited both 45S precursor rRNA production and cell proliferation to a greater extent than did depletion of CHD7L alone. Furthermore, we found that, like CHD7L, CHD7S binds to Sox2 in the nucleoplasm. Unexpectedly, however, whereas over‐expression of CHD7L promoted Sox2‐mediated transcriptional regulation, over‐expression of CHD7S suppressed it. These results indicate that CHD7S functions cooperatively or antagonistically with CHD7L in the nucleolus and nucleoplasm, respectively.
Random S-Box generation in AES by changing irreducible polynomial

The S-Box and Inverse S-Box in the tradition advance encryption standard is fixed and it is made by the composite field arithmatic to find the multiplicative inverse in the finite field GF (28). But in traditional AES the use of irreducible polynomial m(x) = x8+ x4 + x3 + x+1 to find out multiplicative inverse, is known to the attacker. So if we can make use of different irreducible polynomial every time to the finite field of GF (28) and send this the receiver combined with the secret key, then every time a new irreducible polynomial is used and a random S-Box is generated. Hence, the security of the algorithm is enhanced. In this paper, we devise an algorithm, which make use of different irreducible polynomial to finite field of GF (28) to make random S-Box and Inverse S-Box.
Inhibitory effect of epirubicin-loaded lipid microbubbles with conjugated anti-ABCG2 antibody combined with therapeutic ultrasound on multiple myeloma cancer stem cells

Abstract Ultrasound-targeted microbubble destruction (UTMD) technique is thought to improve the chemotherapeutic agent delivery from microbubbles (MBs) in tumor tissues and reduce the side effects in non-tumor tissues. Multiple myeloma (MM) is a bone marrow cancer and remains to be an incurable disease. In this study, we used the UTMD technique to investigate the inhibitory effect of our developed novel reagent on MM cancer stem cells (CD138−CD34−MM CSCs) that are MM cells with CD138−CD34− phenotypes, responsible for MM-initiating potential, drug resistance and eventual relapse. The preparatory steps of novel reagent was first epirubicin (EPI)-loaded in the lipid MBs that was consisted of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]-biotin, dipalmitoyl-phosphatidylglycerol and 25-NBD-cholesterol, then anti-ABCG2 monoclonal antibody (mAb) was conjugated onto the MB surface to form EPI-MBs+mAb. CD138−CD34−MM CSCs were isolated from human MM RPMI 8226 cell line by the magnetic associated cell sorting method. The results showed that the attenuated proliferation, migration and invasion ability, and increased apoptosis were observed when MM CSCs were incubated with a various agents. EPI-MBs+mAb combined with therapeutic ultrasound significantly promoted the MM CSC apoptosis compared with EPI, EPI-MBs alone or EPI-MBs+mAb without ultrasound exposure. These results suggest that the developed EPI-MBs+mAb combined with therapeutic ultrasound remarkably induced MM CSC apoptosis in vitro.
The transition from primary to secondary education : a study of the voices of children and teachers in the Netherlands

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The Tools at Hand

This new IEEE Software column aims to explore the interplay between software development and the tools we apply to the problem. Column installments will discuss specific software construction activities from the standpoint of the tools we can employ-the tools of our trade. This column takes a broad look at how our tools stack up and lists the authorýs top 10 list of software tool sins.
Mobility and Saturation Velocity in Graphene on SiO2

We examine mobility and saturation velocity in graphene on SiO2 above room temperature (300-500 K) and at high fields (~1 V/um). Data are analyzed with practical models including gated carriers, thermal generation, "puddle" charge, and Joule heating. Both mobility and saturation velocity decrease with rising temperature above 300 K, and with rising carrier density above 2x10^12 cm^-2. Saturation velocity is >3x10^7 cm/s at low carrier density, and remains greater than in Si up to 1.2x10^13 cm^-2. Transport appears primarily limited by the SiO2 substrate, but results suggest intrinsic graphene saturation velocity could be more than twice that observed here.
Accepted Manuscript Title : Effect of Case Management on Glycemic Control and Behavioral Outcomes for Chinese People with Type 2 Diabetes : A 2-year Study

Objective To examine the effect of case management on glycemic control and behavioral outcomes in adults with Type 2 diabetes in China. Methods Participants were randomly assigned to a 1-year case management (CM) group (n=60) or control group (n=60). Monthly case management visits included identifying individuals’ diabetes-related problems, setting goals, planning self-care, and evaluating progress. During a 1-year follow-up, all participants attended visits every 3 months without intervention. Results In the CM vs. the control group, HbA1c was reduced at 6 months compared to baseline (P = 0.034), with trends at 12 and 24 months, and empowerment ability improved (P < 0.05). Also in the CM vs. controls, total self-care behaviors, the frequency of exercise, blood glucose testing, and foot care were higher (P < 0.001) at 12 months, and the percentage of individuals with HbA1c < 7.0% was higher (P = 0.035) at 24 months. Conclusion The case management intervention in China was effective at 6 months and, based on trends in HbA1c at 12 and 24 months and results for behavioral outcomes, the intervention shows promise and warrants more research. Practice implications A case management approach can enhance behavior change and glycemic control in Chinese with diabetes.
Focused microwave-assisted extraction of cocaine and benzoylecgonine from coca leaves.

Extraction of cocaine and benzoylecgonine from coca leaves was performed by focused microwave-assisted extraction (FMAE). Cocaine extraction was optimised with respect to the nature of the extracting solvent, the particle size distribution, the moisture of the sample, the applied microwave power and the radiation time. A central composite design was used to optimise the two latter parameters and to assess the robustness of the extraction method around the best conditions. FMAE generated extracts similar to those obtained by conventional solid-liquid extraction but in a more efficient manner, i.e. 30 s were sufficient to extract cocaine quantitatively from leaves. Analyses of cocaine and benzoylecgonine in coca leaves was carried out by capillary GC-FID and GC-MS for peak identification, as well as by capillary electrophoresis with UV detection.
A triple-band microstrip passive device based on quasi hybrid-ring coupler feeding

We present a triple-band microstrip passive using a quasi-hybrid-ring coupler feeding. The proposed hybrid-ring feeder is based on the rat-race coupling mechanism using a balanced mode arrangement. The input excitation energy is split into two superimposed excitation electromagnetic waves travelling in opposite direction though with equal amplitude but with 1800 phase difference. The proposed feeder caused excitation resonance at modes TM11, TM02, and TM20 leading to triple bands. The findings have been validated using available numerical method and by measurement.