Miracle-dz/UniFAR-FTUs huggingface dataset:
Interactive comment on “A predictive group-contribution model for the viscosity of aqueous organic aerosol” by Natalie R.

The manuscript by Gervasi and co-workers presents a computational estimation tool for the viscosity of aqueous and organic mixtures of chemical substances. The model combines previously published estimation methods for pure compound viscosity (via Tg of organic molecules from DeRieux et al. (2018) and for Tg of water from Dehaoui et al. (2015)), an updated mixing rule based on GC-UNIMOD, and uses the AIOMFAC thermodynamic model for calculation of activity coefﬁcients. The authors demonstrate the need for activity coefﬁcient-based calculation of viscosity with signiﬁcant deviations between experiment and theory that would be obtained using simpler mixing rules. While there is not much innovation within the utilized substructures, uniﬁcation of sev-eral tools into AIOMFAC-VISC and outlining strengths and weaknesses presents a
Identiﬁcation and Characterization of the caiF Gene Encoding a Potential Transcriptional Activator of Carnitine Metabolism in Escherichia coli

Expression of the Escherichia coli caiTABCDE and ﬁxABCX operons involved in carnitine metabolism is induced by both carnitine and anaerobiosis. When cloned into a multicopy plasmid, the 3 (cid:42) region adjacent to the caiTABCDE operon was found to increase levels of carnitine dehydratase activity synthesized from the chromosomal caiB gene. The nucleotide sequence was determined, and it was shown to contain an open reading frame of 393 bp named caiF which is transcribed in the direction opposite that of the cai operon. This open reading frame encodes a protein of 131 amino acids with a predicted molecular mass of 15,438 Da which does not have any signiﬁcant homology with proteins available in data libraries. In vivo overexpression consistently led to the synthesis of a 16-kDa protein. The caiF gene was transcribed as a monocistronic mRNA under anaerobiosis independently of the presence of carnitine. Primer extension analysis located the start site of transcription to position 82 upstream of the
INFLUENCE OF CERTAIN CATIONS ON OF ACETIC THIOKINASE FROM SPINACH LEAVES 1,2

The first evidence for a cofactor necessary in acetate metabolism was provided by Nachmansohn and Machado (13) who discovered a soluble enzyme system in extracts of brain tissue which catalyzed the acetylation of choline in the presence of adenosine triphosphate (ATP). Lipmann (8) and Kaplan and Lipmann (5) described an enzyme system in extracts of pigeon liver which catalyzed the ATP and coenzyme A (CoA) dependent acetylation of sulfanilamide. These investigators were the first to identify CoA as a necessary factor in acetate activation. Final proof of the constitution of active acetate was provided when Lynen and Reichert (10) isolated and identified acetyl CoA. Enzyme extracts were obtained from pig heart and rabbit heart by Beinert et al (1) and pigeon liver and yeast by Jones et al (4) which catalyzed the reversible reaction of ATP, acetate, and CoA to yield acetyl CoA, adenosine monophosphate (AMP), and inorganic pyrophosphate (PP). The overall reaction is formulated in the following equation:
Enhanced System Usability Scale for Adaptive Courses

– The usage and complexity of learning management systems is increasing continuously. The System Usability Scale (SUS) is a well-known and widely used scale to measure usability of web applications. It is also used in the context of e-learning and several applications were done in popular learning management systems. This study uses a version of the (SUS) translated from English to German on adaptive courses in Moodle and compares the results with the results from a previous study on non-adaptive courses. In addition to comparing results from adaptive and non-adaptive courses, this study also tests the two-factor structure consisting of usability and learnability and suggests two additional items to be included into the learnability factor. In the evaluation of adaptive courses, the total SUS value is lower than non-adaptive courses at our university. In particular, the SUS value for the learnability factor is far lower. It also shows that some items of our German version of the SUS are not suitable for evaluating adaptive courses.
Advances in Life Course Research Later-life employment trajectories and health

Background: Despite the recent policy push to keep older adults in the labour force, we know almost nothing about the potential health consequences of working longer. Drawing on a life course approach that considers stability and change in employment patterns, this study examines the relationship between long-term labour market involvement in later life and self-rated health. Methods: Our data are from the Health and Retirement Study (1992 – 2012) for the cohort born 1931 – 1941 (N = 6522). We used optimal matching analysis to map employment trajectories from ages 52 – 69, and then logistic regression to examine associations between these trajectories and self-rated health in the early 70s, net of socio-demographics, household resources and prior health. Findings: Women prevail in groups characterized by a weak(er) attachment to the labour market and men, in groups signifying a strong(er) attachment. Men who downshifted from full-time to part-time work around age 65 were the least likely to report poor health in their early 70s.Women had the best health if they remained employed, either full-time or part-time. However, unlike men, they appeared to bene ﬁ t most in health terms when part-time hours were part of a longer-term pattern. Conclusion: While our study ﬁ ndings show that continuing to work in later life may be positively associated with health, they also suggest the need for ﬂ exible employment policies that foster opportunities to work part-time.
The Effect of Alternative Offloading Techniques on The Area of Diabetic Foot Ulcus towards The Duration of The Wound Healing Process

Diabetic foot ulcers that occur in the sole will get high pressure, so this pressure must be controlled because repeated pressure can delay the wound healing process. Nursing interventions that are carried out to reduce pressure on the soles of the feet are to perform pressure control management, namely offloading techniques using felt padding. The purpose of this study was to determine the effect of alternative offloading techniques (felt padding) in the area of diabetic foot ulcers on the length of the wound healing process in Bekasi district health services. This research uses Quasi Experiment Design method. The sample used in this study were 15 respondents. The conclusion in this study is that by using the offloading technique, the average length of the wound healing process is a minimum of 24 days and a maximum of 52 days, but there is no difference in the length of the wound healing process between the three wound areas (phalanges, metatarsals and calcaneus) with a p-value. = 0.390 (>0.005). Recommendations for nursing services using the offloading technique with the felt padding type can be made a standard in the medical world, especially in treating diabetic foot ulcers located in the sole.
Investigating active galactic nuclei with low frequency radio observations

Low frequency radio astronomy allows us to observe the fainter and older synchrotron emission from the relativistic plasma associated with active galactic nuclei (AGN) in galaxies and clusters. In this thesis, we use the Giant Metrewave Radio Telescope to explore the impact that AGN have on their surroundings. We present deep, high quality, 150-610 MHz radio observations for a sample of fifteen predominantly cool-core galaxy clusters. For well-known clusters such as MS0735, our low noise images and multi-frequency data enable us to see in improved detail the radio lobes working against the intracluster medium, whilst deriving the energies and timescales of this event. Our excellent field of view allowed us to explore the point-source like radio AGN for a subsample of our clusters. We used additional optical and infra-red data to identify cluster members, remove radio contamination and investigate the energetics of the many cluster galaxies. We find that low mass radio-loud AGN can easily quench the star formation at their core and compare our observations with the results of cosmological hydrodynamical simulations, to explore the mechanical and binding energy levels over a large range of galaxy masses. Comparing our sample to published X-ray cavity powers, we find an improved relation from our integrated radio luminosities, allowing a more accurate estimation of jet powers when X-ray or radio observations are unavailable. Our deepest low-frequency radio observations of these well-known clusters will yield valuable information about the nature of feedback when combined with X-ray observations of comparable depth.
A Quantitative Study on Live Virtual Machines Migration in Virtualized Computing Environment

—The live virtual machines migration is a widely used technique in cloud computing environments because it is not necessary to stop services hosted on the migrated virtual machines. This paper aims to conduct an experimental and quantitative study on the migration of virtual machines through the evaluation of different scenarios. For this, a fully virtualized computing environment was implemented with the purpose of performing experiments that allow to analyze the influence of the live migration process in the performance of the services offered by the virtual machines migrated. The following metrics were evaluated: number of requests per second, server response time, throughput, latency and total migration time. Benchmarks ab-Apache Benchmark and YCSB-Yahoo! Cloud Serving Benchmark were used to generate the workload for the Web services and Database (Cassandra), respectively. The results obtained revealed that during the migration period, the services considered presented a reduction in their performance, but although there is a decrease, the service is not interrupted, thus complying with the principles of live migration.
THE IMPACT OF SUCCINYLCHOLINE OR VECURONIUM ON INTRAOCULAR PRESSURE IN RELATION TO THE ACCEPTANCE OF PROPOFOL

: Background and Aim: The performance of the ophthalmic medical procedure, especially once globe is open, be contingent to a large amount on the measure of the intraocular pressure during anaesthesia, nevertheless similarly during the support period. Intubation is typically accomplished through usage of non-depolarizing muscle relaxants inspired by a paranoid dread of swelling intraocular pressure through depolarizing relaxants. The current review has been embraced with a plan to assess impact of succinylcholine or vecuronium on intraocular pressure in relation to the acceptance of propofol. Methods: This existing research was conducted at Jinnah Hospital, Lahore from October 2017 to September 2018. Sixty cases of mutually genders with ASA status I and II, aged 16 to 52 years, remained designated for examination for one year. Cases through medically enormous ocular disease, elevated IOP, cardiorespiratory disease, CNS disease, difficult airway, corpulence, those receiving medications that may affect IOP, and in whom the usage of succinylcholine is contraindicated, were prohibited. Cases were arbitrarily divided into two equivalent sets. Anesthesia was encouraged through propofol 2 mg/kg for more than 36 seconds in all cases. In Set V cases, vecuronium was applied and in Set S cases, succinylcholine was used for intubation. The factual investigation was concluded with a unidirectional ANOVA using SPSS 23 programming rendering. Results: In Set V, the reduction in IOP of 29.48% after enrollment and one minute after intubation was increased to 15.54%, but remained below the gauge estimate. In Set S, there was a 29.15% rise in IOP after enrollment and one minute after intubation, the IOP increased to 36.57%. A substantial rise in beat frequency and circulatory pressure was renowned in Set S after operator acceptance in addition intubation associated to Set V. Conclusion: Propofol and vecuronium give a fantastic intubation illness and this is an appropriate operator for tracheal intubation in elective ophthalmic intervention and crisis where an IOP rise is unfortunate.
University of Birmingham Look but don't touch

When planning interactions with nearby objects, our brain uses visual information to estimate shape, material composition, and surface structure before we come into contact with them. Here we analyse brain activations elicited by different types of visual appearance, measuring fMRI responses to objects that are glossy, matte, rough, or textured. In addition to activation in visual areas, we found that fMRI responses are evoked in the secondary somatosensory area (S2) when looking at glossy and rough surfaces. This activity could be reliably dis- criminated on the basis of tactile-related visual properties (gloss, rough, and matte), but importantly, other visualproperties(i.e.,colouredtexture)didnotsubstantiallychangefMRIactivity.Theactivitycouldnotbesolely duetotactileimagination,asaskingexplicitlytoimaginesuchsurfacepropertiesdidnotleadtothesameresults. These ﬁ ndingssuggestthatvisualcuestoanobject'ssurfacepropertiesevokeactivityinneuralcircuitsassociated with tactile stimulation. This activation may re ﬂ ect the a-priori probability of the physics of the interaction (i.e., the expectation of upcoming friction) that can be used to plan ﬁ nger placement and grasp force.
Reliability Assessment of Digital Terrain Models Drawn from Digital Photogrammetry

The modern techniques of Digital Photogrammetry are used to reconstruct Digital Terrain Models (DTMs) from photosets taken by commercial digital cameras. The algorithms are based on the Multiview Stereo Vision (MVS) which draw a 3D model in the space through the internal setting of the digital photosets. In this study, two open source codes, VisualSfM and CMP-MVS are used to combine the photosets to build the DTM of the Civitaluparella (CH) quarry wall. This latter is compared with the reference DTM reconstructed by a Laser Scanner device (in this application the Long-Range Topcon GLS-1500 laser scanner has been used). The comparison evidences spatial errors about (cid:2) 0.1m along y and z directions and (cid:2) 0.2m along x direction for the DTM drawn by the Digital Photogrammetry for the vertical quarry wall . Hence, these outcomes confirm the reliability of the Digital Photogrammetry codes as fast and cheap tool for drawing accurate Digital Terrain Models. These DTMs can be used for generating Digital Elevation Models (DEMs) for engineering geological applications such as slope stability analyses
Cardiac output measurement during exercise in COPD: 1 A comparison of dye dilution and impedance 2 cardiography

Impedance cardiography (IC) derived from morphological analysis of the thoracic impedance signal is now commonly used for non-invasive assessment of cardiac output (CO) at rest and during exercise. However, in COPD, the two published studies 39 disagree about its accuracy. We therefore compared concurrent CO measurements 40 captured by IC (PhysioFlow TM : CO IC ) and by the indocyanine green dye dilution method 41 (CO DD ) in patients with COPD. Fifty paired CO measurements were concurrently 42 obtained using the two methods from 10 patients (FEV 1 :50.5±17.5%predicted) at rest 43 and during cycling at 25%, 50%, 75% and 100% peak work rate. From rest to peak 44 exercise CO IC and CO DD were strongly correlated (r=0.986, p<0.001). The mean 45 absolute and percentage differences between CO IC and CO DD were 1.08 liters/min 46 (limits of agreement (LoA): 0.05 to 2.11 liters/min) and 18±2%, respectively, with 47 impedance cardiography yielding systematically higher values. Bland-Altman analysis 48 indicated that during exercise only 7 of the 50 paired measurements differed by more 49 than 20%. When data were expressed as changes from rest, correlations and 50 agreement between the two methods remained strong over the entire exercise range 51 (r=0.974, p<0.001, with no significant difference: 0.19 Liters/min; LoA: -0.76 to 1.15 52 liters/min). Oxygen uptake (VO 2 ) and CO DD were linearly related: r=0.893 (p<0.001), 53 CO DD = 5.94 x VO 2 + 2.27 liters/min. Similar results were obtained for VO 2 and CO IC (r 54 =0.885, p<0.001, CO IC = 6.00 x VO 2 + 3.30 liters/min). These findings suggest that 55 impedance cardiography provides an acceptable CO measurement from rest to peak 56 cycling exercise in patients with COPD.
Specificity(Qa-1) with Shared Peptide-Binding H2-T11 Gene Product, a Paralog of H2-T23 Expression of the Mouse MHC Class Ib

The mouse MHC class Ib gene H2-T11 is 95% identical at the DNA level to H2-T23, which encodes Qa-1, one of the most studied MHC class Ib molecules. H2-T11 mRNAwas observed to be expressed widely in tissues of C57BL/6 mice, with the highest levels in thymus. To circumvent the availability of a speciﬁc mAb, cells were transduced with cDNA encoding T11 with a substituted a 3 domain. Hybrid T11D3 protein was expressed at high levels similar to control T23D3 molecules on the surface of both TAP + and TAP 2 cells. Soluble T11D3 was generated by folding in vitro with Qa-1 determinant modiﬁer, the dominant peptide presented by Qa-1. The circular dichroism spectrum of this protein was similar to that of other MHC class I molecules, and it was observed to bind labeled Qa-1 determinant modiﬁer peptide with rapid kinetics. By contrast to the Qa-1 control, T11 tetramers did not react with cells expressing CD94/NKG2A, supporting the conclusion that T11 cannot replace Qa-1 as a ligand for NK cell inhibitory receptors. T11 also failed to substitute for Qa-1 in the presentation of insulin to a Qa-1–restricted T cell hybridoma. Despite divergent function, T11 was observed to share peptide-loading speciﬁcity with Qa-1. Direct analysis by tandem mass spectrometry of peptides eluted from T11D3 and T23D3 isolated from Hela cells demonstrated a diversity of peptides with a clear motif that was shared between the two molecules. Thus, T11
Assessment of Self Care Behaviors of Patients with Congestive Heart Failure: (Suggested Nursing Guidelines)

Aim: to assess self care behavior of patients with heart failure, design suggested nursing guidelines for patients with heart failure. Subjects and methods; The study was conducted in the internal medicine department and cardiac clinic at Assiut University Hospital. A convenience sample of 60 adult patients with congestive heart failure grade I, II, III from both males and females aged between (18-65) years old were included in this study. Tools ; Tool ( 1 ) patient assessment sheet and Tool ( 2 ) Heart Failure Self-Care behavior Scale. Results ; The findings revealed that the majority of patients aged between (41-60) yrs old, regarding to patient’s knowledge, (60%) of patients had unsatisfactory level of knowledge, there was a statistical significant relation between self care behavior and knowledge. Conclusion; Based on findings of the present study, it can be concluded that, patients were not adherent to self care behaviors; Socio demographic characteristic had clear effect on the knowledge of the patients. Also, the study concluded high percentage from patients had poor knowledge which affected on patients self care behavior; results of this study could be useful for the development of nursing interventions that can promote/improve self-care in this population. Recommendations : Health education including the suggested nursing guidelines for patients with congestive heart failure is mandatory to improve self care behavior.
Suramin Disrupts Receptor-G Protein Coupling by Blocking Association of G Protein (cid:1) and (cid:2)(cid:3) Subunits

Most drugs target a receptor for a hormone or neurotransmitter. A newer strategy for drug development is to target a downstream signaling element, such as the G protein associated with a recep- tor. Suramin is considered a lead compound targeting this moiety. It inhibits binding of guanosine 5 (cid:1) - O -(3-thiotriphosphate) (GTP (cid:3) S) to G proteins and reduces agonist binding to G protein-coupled receptors. Suramin is thought to uncouple the G protein from its associated receptor, although there is no direct evidence for this mechanism. We have now examined the effect of suramin on G protein signaling for the vasoactive intestinal peptide (VIP) recep- tor in lung. The primary experimental strategy was a two-step cross-linking reaction that covalently captures the VIP-receptor-G protein ternary complex. Such cross-linking provided the first direct evidence that suramin physically disrupts receptor-G protein coupling. We investigated how this uncoupling relates to the inhibition of GTP (cid:3) S binding. Suramin indiscriminately hindered the dissociation of various guanine nucleotides from the G protein, implying that its action is not allosteric. Further cross-linking studies suggested that suramin does not obstruct the receptor dock- ing site directly but appears to block the interface between G protein (cid:1) and (cid:2)(cid:3) subunits. Observations with a purified system of recombinant G protein subunits without a receptor yielded direct evidence that suramin suppresses the association between these subunits. This action can explain how it both disrupts receptor-G protein coupling and inhibits guanine nucleotide release. The im-proved understanding of suramin’s action advances the develop- ment
An Introduction to Stein's Method

A common theme in probability theory is the approximation of complicated probability distributions by simpler ones, the central limit theorem being a classical example. Stein's method is a tool which makes this possible in a wide variety of situations. Traditional approaches, for example using Fourier analysis, become awkward to carry through in situations in which dependence plays an important part, whereas Stein's method can often still be applied to great effect. In addition, the method delivers estimates for the error in the approximation, and not just a proof of convergence. Nor is there in principle any restriction on the distribution to be approximated; it can equally well be normal, or Poisson, or that of the whole path of a random process, though the techniques have so far been worked out in much more detail for the classical approximation theorems. This volume of lecture notes provides a detailed introduction to the theory and application of Stein's method, in a form suitable for graduate students who want to acquaint themselves with the method. It includes chapters treating normal, Poisson and compound Poisson approximation, approximation by Poisson processes, and approximation by an arbitrary distribution, written by experts in the different fields. The lectures take the reader from the very basics of Stein's method to the limits of current knowledge.
Ranking the vertices of a paired comparison digraph with normal completeness theorems

A paired comparison digraph $D = ( V,A )$ is a weighted digraph in which the sum of the weights of arcs, if any, joining two distinct vertices is exactly one; otherwise, there exist no arcs joining them. A one-to-one mapping $\alpha$ from V onto $\{ 1,2, \cdots , | V | \}$ is called a ranking of D. We define the backward arcs and the backward length of $\alpha$. An optimal ranking of D is a ranking whose backward length is minimum among those of all rankings of D. Our method of ranking the vertices of D is one that makes use of these optimal rankings. For certain classes of paired comparison digraphs, we show that the optimal rankings can be explicitly computed.