Miracle-dz/UniFAR-FTUs huggingface dataset:
Sensors Data Analysis in Supervisory Control and Data Acquisition (SCADA) Systems to Foresee Failures with an Undetermined Origin

This paper presents the design and implementation of a supervisory control and data acquisition (SCADA) system for automatic fault detection. The proposed system offers advantages in three areas: the prognostic capacity for preventive and predictive maintenance, improvement in the quality of the machined product and a reduction in breakdown times. The complementary technologies, the Industrial Internet of Things (IIoT) and various machine learning (ML) techniques, are employed with SCADA systems to obtain the objectives. The analysis of different data sources and the replacement of specific digital sensors with analog sensors improve the prognostic capacity for the detection of faults with an undetermined origin. Also presented is an anomaly detection algorithm to foresee failures and to recognize their occurrence even when they do not register as alarms or events. The improvement in machine availability after the implementation of the novel system guarantees the accomplishment of the proposed objectives.
SPARE: A Spectral Peak Recovery Algorithm for PPG Signals Pulsewave Reconstruction in Multimodal Wearable Devices

The photoplethysmographic (PPG) signal is an unobtrusive blood pulsewave measure that has recently gained popularity in the context of the Internet of Things. Even though it is commonly used for heart rate detection, it has been lately employed on multimodal health and wellness monitoring applications. Unfortunately, this signal is prone to motion artifacts, making it almost useless in all situations where a person is not entirely at rest. To overcome this issue, we propose SPARE, a spectral peak recovery algorithm for PPG signals pulsewave reconstruction. Our solution exploits the local semiperiodicity of the pulsewave signal, together with the information about the cardiac rhythm provided by an available simultaneous ECG, to reconstruct its full waveform, even when affected by strong artifacts. The developed algorithm builds on state-of-the-art signal decomposition methods, and integrates novel techniques for signal reconstruction. Experimental results are reported both in the case of PPG signals acquired during physical activity and at rest, but corrupted in a systematic way by synthetic noise. The full PPG waveform reconstruction enables the identification of several health-related features from the signal, showing an improvement of up to 65% in the detection of different biomarkers from PPG signals affected by noise.
Effect of Brain and Pulse Waves on Safety Consciousness and Safety Commitment of Workers at Construction Sites

Even though individual mental and health status largely affects the safety in industrial sites, most studies for preventing industrial accidents are mainly focused on external factors such as regulations, education, etc. In this study, the effect of individual factors on safety (i.e., safety consciousness and safety commitment) was analyzed by collecting brainwave and pulse data at construction sites where industrial accidents have occurred with the highest percentage. The effects of brain stress, concentration, brain activity, and left and right brain imbalance on safety accidents were evaluated through brain wave measurements. In addition, the effects of cumulative fatigue, physical vitality, autonomic nerve health, and autonomic balance were identified through pulse wave measurements. Data were acquired for 180 construction workers at various construction sites, and the workers were classified into three grades according to factors that affected safety accidents at construction sites. Then, the safety consciousness and safety commitment levels of workers corresponding to each grade of the influence factors were evaluated by conducting a questionnaire on safety consciousness and safety commitment. As a result, the characteristics of brain and pulse waves required to improve safety consciousness and safety commitment ability of workers at construction sites were explored.
Relationships Between Sprinting, Broad Jump, and Vertical Jump Kinetics Are Limited in Elite, Collegiate Football Athletes

Abstract Boone, JB, VanDusseldorp, TA, Feito, Y, and Mangine, GT. Relationships between sprinting, broad jump, and vertical jump kinetics are limited in elite, collegiate football athletes. J Strength Cond Res 35(5): 1306–1316, 2021—To evaluate the relationships and agreement in kinetics measured during a 10-yd sprint, a standing broad jump (SBJ), and a vertical jump (VJ), 73 collegiate football players (22.3 ± 0.8 years, 188 ± 7 cm, 113 ± 23 kg) volunteered for this cross-sectional study over a 3-year period. At the beginning of each athlete's off-season training phase and after a standard warm-up, each athlete completed 2–3 maximal trials of each test while tethered to a robotic, cable-resistance device (10-yd sprint and SBJ) or a linear position transducer (VJ alone). Force (N), velocity (m·s−1), and power (W) were measured during the first 2 steps, acceleration phase (units·step−1), and entire 10-yd sprint, and the entire SBJ and VJ. Spearman and partial correlations (controlling for stature) revealed small-to-moderate relationships (r = −0.30 to −0.34) between the second sprinting step and VJ force. Small negative relationships were also noted between sprinting and VJ force and power, but not when controlling for height. Agreement was determined by examining relationships between the differences in and averaged kinetics measured on each test. Trivial-to-small relationships (r < 0.29) were observed between sprinting (first step and 10-yd) and VJ velocity, and between VJ and SBJ velocity, although coefficient of variation (CV) ranged between 64 and 104%. All other relationships ranged from moderate-to-practically perfect with CVs exceeding 500%. Although some relationships exist between sprinting and jumping kinetics, their agreement is variable. These data suggest that coaches and athletes should not use one of these assessments in place of, or to predict performance in, the other assessments.
INZ‐701 Prevents Ectopic Tissue Calcification and Restores Bone Architecture and Growth in ENPP1‐Deficient Mice

Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is the major enzyme that cleaves extracellular adenosine triphosphate (ATP) to generate pyrophosphate (PPi), an inorganic metabolite with potent anticalcification activity. Loss‐of‐function mutations cause hypopyrophosphatemia and lead to a state of ENPP1 deficiency, which has an acute infantile phase known as generalized arterial calcification of infancy (GACI) and a pediatric to adult phase known as autosomal‐recessive hypophosphatemic rickets type 2 (ARHR2). ENPP1 deficiency manifests as ectopic calcification of multiple tissues, neointimal proliferation, premature mortality, impaired growth, and bone deformities. INZ‐701, a human ENPP1‐Fc protein, is in clinical development as an enzyme replacement therapy for the treatment of ENPP1 deficiency. The pharmacokinetic and pharmacodynamic profile and therapeutic effect of INZ‐701 were investigated in Enpp1asj/asj mice, a murine model of ENPP1 deficiency. Enpp1asj/asj mice have undetectable plasma PPi, lower plasma phosphate, and higher FGF23 levels compared with wild‐type (WT) mice. Enpp1asj/asj mice on the acceleration diet, containing high phosphate and low magnesium, quickly develop clinical signs, including dehydration, rough hair coat, pinned ears, stiffed legs, and hunched back. Enpp1asj/asj mice treated with vehicle had aforementioned clinical signs plus severe ectopic calcification in multiple tissues and bone defects, characteristics of the clinical phenotype observed in GACI and ARHR2 patients. Our results showed a durable PPi response for more than 3 days after a single dose of INZ‐701. Treatment of ENPP1‐deficient mice every other day with INZ‐701 for 8 weeks restored circulating levels of PPi, prevented pathological calcification in all the tested organs, restored growth parameters, corrected bone defects, improved clinical signs, and decreased mortality in Enpp1asj/asj mice, demonstrating the potential of INZ‐701 to treat ENPP1 deficiency. © 2021 American Society for Bone and Mineral Research (ASBMR).
Trajectories of Recovery after Atrial Fibrillation Ablation

Ablation procedures are common for patients with atrial fibrillation (AF), yet evidence is limited about patient perceptions of their recovery following ablation. We sought to expand understanding of this recovery process. Twenty participants undergoing their first AF ablation completed semi-structured interviews prior to ablation (baseline) and at one, three, and six months post AF ablation. Pre-procedure education is modeled after education used for other ablation procedures, preparing patients to expect a single recovery trajectory. We identified two recovery trajectories that varied in speed of symptom resolution: sustained improvement and pseudo improvement. Recovery was slower than expected in both trajectories. Moreover, returning to desired activity levels consistently lagged behind other symptom resolution by approximately two months. A more accurate understanding of what patients experience post-ablation, as illustrated in these findings, serves as a beginning step to alter patient education prior to AF ablation to better prepare individuals for the recovery process.
Copper-mediated annulation of 2-(1-arylvinyl) anilines and aryl nitrosos towards 2,3-diaryl-2H-indazoles

A copper-mediated annulation of 2-(1-substituted vinyl) anilines and aryl nitrosos is developed for the synthesis of 2,3-diaryl pyrazoles. Compared with previously reported sequential azobenzene C–H ortho-acylation, reduction and cyclization procedures towards such frameworks, no external reductant was required during this cyclization, where the vinyl served as a formal innate reductant. Moreover, in this procedure, no selectivity was involved in the case of Ar1 ≠ Ar2.
Active Case Finding of Current Bornavirus Infections in Human Encephalitis Cases of Unknown Etiology, Germany, 2018–2020

Human bornavirus encephalitis is a severe and often fatal infection caused by variegated squirrel bornavirus 1 (VSBV-1) and Borna disease virus 1 (BoDV-1). We conducted a prospective study of bornavirus etiology of encephalitis cases in Germany during 2018–2020 by using a serologic testing scheme applied along proposed graded case definitions for VSBV-1, BoDV-1, and unspecified bornavirus encephalitis. Of 103 encephalitis cases of unknown etiology, 4 bornavirus infections were detected serologically. One chronic case was caused by VSBV-1 after occupational-related contact of a person with exotic squirrels, and 3 acute cases were caused by BoDV-1 in virus-endemic areas. All 4 case-patients died. Bornavirus etiology could be confirmed by molecular methods. Serologic testing for these cases was virus specific, discriminatory, and a practical diagnostic option for living patients if no brain tissue samples are available. This testing should be guided by clinical and epidemiologic suspicions, such as residence in virus-endemic areas and animal exposure.
Corrosion Inhibition Potential of Ascorbic acid on Carbon Steel in Acid Media

Abstract : Ascorbic acid (AA), or vitamin C, is a water-soluble vitamin essential in the human beings, a scavenger of free radicals in biological systems, an antioxidant and a cofactor of several enzymes. It is well known for its ability to increase high-density lipoprotein production, to lower blood sugar and to reduce the risk for cardiovascular diseases. Corrosion control of metals is of technical, environmental, economical, and aesthetical importance. The inhibitive action of Ascorbic acid on the corrosion behavior of carbon steel (CS) in 1M HCl was studied using weight loss, potentiodynamic polarization, electrochemical impedance spectroscopy (EIS) and effect of temperature. The results obtained revealed that AA was a good inhibitor in 1M HCl and the inhibition efficiency increased with increasing inhibitor’s concentration. The adsorption of AA was found to obey Langmuir adsorption isotherm, The corresponding activations prametres in the absence and presence of inhibitor were determined and discussed. The inhibition efficiency was closely related to orbital energies (E HOMO and E LUMO ). The correlation between quantum parameters and experimental inhibition efficiency has been validated. Keywords: Carbon steel, Polarization curves, Ascorbic acid, Free Energy, Corrosion inhibition,
Chicken IgY Antibodies Provide Mucosal Barrier against SARS-CoV-2 Virus and Other Pathogens.

BACKGROUND This mini review includes two case descriptions. It introduces the use of chicken egg yolk antibody (IgY) solutions in the prevention and cure of viral and bacterial infections. Application for the protection against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), rotavirus, and influenza viruses, as well as for the eradication of Pseudomonas aeruginosa, caries, various enteric bacteria and other pathogens, and toxins have been developed. This approach is a fast, reliable, safe, and tested method for producing molecular shield and protection against emerging pathogens and epidemics. In the current pandemic situation caused by coronavirus disease-2019 (COVID-19), this method of passive immunization could be applied for rapid protection against modifiable agents. The specific IgY antibodies start to accumulate into egg yolks about 3 weeks after the immunization of the chicken. The product can be collected safely, as the antigen is not found in the eggs. This method for microbial safety uses natural means and commonly used food substances, which have been tested and could be produced for both blocking epidemics and applying personalized medicine.
Development of the Quality of Life Questionnaire (SF-36) for Patients with β-Thalassemia Major and β-Thalassemia Intermedia Based on Extended Rasch Analysis

Abstract The quality of life (QoL) questionnaire (SF-36) contains 36 questions in eight subscales. It requires much time to fill in by the respondent. The objective of this study was to use Rasch models to develop a questionnaire that brings the desired outcome of the QoL of people. Therefore, a new questionnaire was provided that is more motivating and time-saving for respondents than SF-36. The QoL of life assessment data of 325 β-thalassemia major (β-TM) and β-thalassemia intermedia (β-TI) patients in Kerman, Iran, was used as research data. In this study, the appropriate questions were classified in a limited dimensional framework using the exploratory factor analysis (EFA). The correctness of the factor structure was assessed by confirmatory factor analysis (CFA). The quality of the questions was evaluated by Rasch modeling [partial credit model (PCM)] and item analysis to ensure the validity and reliability of the questionnaire. Finally, the Pearson correlation coefficient was used to compare the new questionnaire with the previous one. This process resulted in the development of a new questionnaire with five subscales and 20 questions. The construct validity of the new questionnaire was good. The reliability index of the questionnaire was 0.75, and the Pearson correlation coefficient between the QoL scores gained from the previous and the new questionnaires was 0.93 that indicates the strength of the correlation. The use of Rasch analysis in this study resulted in the development of a new reliable and valid questionnaire.
Evaluating impacts of forage fish abundance on marine predators

Forage fish—small, low trophic level, pelagic fish such as herrings, sardines, and anchovies—are important prey species in marine ecosystems and also support large commercial fisheries. In many parts of the world, forage fish fisheries are managed using precautionary principles that target catch limits below the maximum sustainable yield. However, there are increasing calls to further limit forage fish catch to safeguard their fish, seabird, and marine mammal predators. The effectiveness of these extra‐precautionary regulations, which assume that increasing prey abundance increases predator productivity, are under debate. In this study, we used prey‐linked population models to measure the influence of forage fish abundance on the population growth rates of 45 marine predator populations representing 32 fish, seabird, and mammal species from 5 regions around the world. We used simulated data to confirm the ability of the statistical model to accurately detect prey influences under varying levels of influence strength and process variability. Our results indicate that predator productivity was rarely influenced by the abundance of their forage fish prey. Only 6 predator populations (13% of the total) were positively influenced by increasing prey abundance and the model exhibited high power to detect prey influences when they existed. These results suggest that additional limitation of forage fish harvest to levels well below sustainable yields would rarely result in detectable increases in marine predator populations.
A platform-agnostic, function first-based antibody discovery strategy using plasmid-free mammalian expression of antibodies

ABSTRACT Hybridoma technology has been valuable in the development of therapeutic antibodies. More recently, antigen-specific B-cell selection and display technologies are also gaining importance. A major limitation of these approaches used for antibody discovery is the extensive process of cloning and expression involved in transitioning from antibody identification to validating the function, which compromises the throughput of antibody discovery. In this study, we describe a process to identify and rapidly re-format and express antibodies for functional characterization. We used two different approaches to isolate antibodies to five different targets: 1) flow cytometry to identify antigen-specific single B cells from the spleen of immunized human immunoglobulin transgenic mice; and 2) panning of phage libraries. PCR amplification allowed recovery of paired VH and VL sequences from 79% to 96% of antigen-specific B cells. All cognate VH and VL transcripts were formatted into transcription and translation compatible linear DNA expression cassettes (LEC) encoding whole IgG or Fab. Between 92% and 100% of paired VH and VL transcripts could be converted to LECs, and nearly 100% of them expressed as antibodies when transfected into Expi293F cells. The concentration of IgG in the cell culture supernatants ranged from 0.05 µg/ml to 145.8 µg/ml (mean = 18.4 µg/ml). Antigen-specific binding was displayed by 78–100% of antibodies. High throughput functional screening allowed the rapid identification of several functional antibodies. In summary, we describe a plasmid-free system for cloning and expressing antibodies isolated by different approaches, in any format of choice for deep functional screening that can be applied in any research setting during antibody discovery.
Why are sodium channel modulators not yet pharmacotherapeutic trailblazers for neuropathic pain?

In peripheral neuropathic pain, the most obvious way would be to prevent or reduce excitability in damaged and intact sensory neurones with sodium channels being the key target. If it is possible to block these channels by local or regional anesthesia, the outcome can be impressive but this local approach is not feasible if the area of nerve damage is ill defined or widespread such as in patients with diabetic painful neuropathy. Thus, systemic sodium channel blockers with pain selective actions could be a game changer. The finding that mammals have 9 sodium channels and that in the main, three, namely, 1.7, 1.8 and 1.9 are rather selectively found in peripheral pain pathways, gives rise to the possibility of systemic yet pain selective sodium channel blockers [1]. A number of preclinical studies using transgenic approaches revealed key roles in pain, in particular neuropathic pain models. Generally, proof of concept arises when a drug has been developed, but here and rapidly, strong proof of concept arrived from recognition of a number of inherited pain disorders involving mutations in Nav 1.7 in particular where the abnormal sodium channel proteins caused a loss or gain of function and corresponding pain abnormalities [1]. Similar inherited changes in Nav 1.8 have been reported indicating that this channel could be an important target too [2]. This provided an impetus for the development of novel pain related 1.7 sodium channel blockers. But some important messages were not taken into account as the field progressed.
Clonal Architectures Predict Clinical Outcome in Gastric Adenocarcinoma Based on Genomic Variation, Tumor Evolution, and Heterogeneity

Stomach adenocarcinoma (STAD) is a highly heterogeneous disease. Due to the lack of effective molecular markers and personalized treatment, the prognosis of gastric cancer patients is still very poor. The ABSOLUTE algorithm and cancer cell fraction were used to evaluate the clonal and subclonal status of 349 TCGA (The Cancer Genome Cancer Atlas)-STAD patients. Non-negative matrix factorization was used to identify the mutation characteristics of the samples. Univariate Cox regression analysis was used to determine the relationship between clonal/subclonal events and prognosis, and the Spearman correlation was used to evaluate the relationship of clonal/subclonal events to tumor mutation burden (TMB) and neoantigens. The evolution pattern of STAD demonstrated great tumor heterogeneity. TP53, USH2A, and GLI3 appeared earliest in STAD and may drive STAD. CTNNB1, LRP1B, and ERBB4 appeared the latest in STAD, and may be related to STAD’s progress. Univariate Cox regression analysis identified four early genes, eight intermediate genes, and seven late genes significantly associated with overall survival. The number of subclonal events in the T stage was significantly different. The N stage, gender, and histological type were significantly different for clonal events, and there was a significant correlation between clonal/subclonal events and TMB/neoantigens. Our results highlight the importance of systematic evaluation of evolutionary models in the clinical management of STAD and personalized gastric cancer treatment.
Current-induced magnetization switching in a nano-scale CoFeB-MgO magnetic tunnel junction under in-plane magnetic field

We study current-induced magnetization switching properties of a magnetic tunnel junction with junction diameter of 19 nm and resistance-area product of 6 Ωμm2 in the nanosecond regime with and without in-plane magnetic field. At zero field, for both parallel (P)-to-anti-parallel (AP) and AP-to-P switchings, the probability of switching PSW approaches unity with the increase of pulse voltage duration τP. However, under in-plane magnetic field, PSW for P-to-AP switching starts to saturate at a value lower than unity with increasing τP, while AP-to-P switching remains the same as in the absence of in-plane magnetic field. This in-plane field dependence of PSW can be partially explained by the influence of electric-field modulation of magnetic anisotropy.We study current-induced magnetization switching properties of a magnetic tunnel junction with junction diameter of 19 nm and resistance-area product of 6 Ωμm2 in the nanosecond regime with and without in-plane magnetic field. At zero field, for both parallel (P)-to-anti-parallel (AP) and AP-to-P switchings, the probability of switching PSW approaches unity with the increase of pulse voltage duration τP. However, under in-plane magnetic field, PSW for P-to-AP switching starts to saturate at a value lower than unity with increasing τP, while AP-to-P switching remains the same as in the absence of in-plane magnetic field. This in-plane field dependence of PSW can be partially explained by the influence of electric-field modulation of magnetic anisotropy.