Miracle-dz/UniFAR-FTUs huggingface dataset:
An Improved Pedestrian Ttracking Method Based on Wi-Fi Fingerprinting and Pedestrian Dead Reckoning

Wi-Fi based positioning has great potential for use in indoor environments because Wi-Fi signals are near-ubiquitous in many indoor environments. With a Reference Fingerprint Map (RFM), fingerprint matching can be adopted for positioning. Much assisting information can be adopted for increasing the accuracy of Wi-Fi based positioning. One of the most adopted pieces of assisting information is the Pedestrian Dead Reckoning (PDR) information derived from inertial measurements. This is widely adopted because the inertial measurements can be acquired through a Commercial Off The Shelf (COTS) smartphone. To integrate the information of Wi-Fi fingerprinting and PDR information, many methods have adopted filters, such as Kalman filters and particle filters. A new methodology for integration of Wi-Fi fingerprinting and PDR is proposed using graph optimization in this paper. For the Wi-Fi based fingerprinting part, our method adopts the state-of-art hierarchical structure and the Penalized Logarithmic Gaussian Distance (PLGD) metric. In the integration part, a simple extended Kalman filter (EKF) is first used for integration of Wi-Fi fingerprinting and PDR results. Then, the tracking results are adopted as initial values for the optimization block, where Wi-Fi fingerprinting and PDR results are adopted to form an concentrated cost function (CCF). The CCF can be minimized with the aim of finding the optimal poses of the user with better tracking results. With both real-scenario experiments and simulations, we show that the proposed method performs better than classical Kalman filter based and particle filter based methods with both less average and maximum positioning error. Additionally, the proposed method is more robust to outliers in both Wi-Fi based and PDR based results, which is commonly seen in practical situations.
Effect of High Intensity Interval Training Compared to Continuous Training on Cognitive Performance in Young Healthy Adults: A Pilot Study

To improve cognitive function, moving the body is strongly recommended; however, evidence regarding the proper training modality is still lacking. The purpose of this study was therefore to assess the effects of high intensity interval training (HIIT) compared to moderate intensity continuous exercise (MICE), representing the same total training load, on improving cognitive function in healthy adults. It was hypothesized that after 6 weeks (3 days/week) of stationary bike training, HIIT would improve executive functions more than MICE. Twenty-five participants exercised three times a week for 6 weeks after randomization to the HIIT or MICE training groups. Target intensity was 60% of peak power output (PPO) in the MICE group and 100% PPO in the HIIT group. After training, PPO significantly increased in both the HIIT and MICE groups (9% and 15%, p < 0.01). HIIT was mainly associated with a greater improvement in overall reaction time in the executive components of the computerized Stroop task (980.43 ± 135.27 ms vs. 860.04 ± 75.63 ms, p < 0.01) and the trail making test (42.35 ± 14.86 s vs. 30.35 ± 4.13 s, p < 0.01). T exercise protocol was clearly an important factor in improving executive functions in young adults.
Endoscopic submucosal dissection with double clip and rubber band traction for residual or locally recurrent colonic lesions after previous endoscopic mucosal resection

Abstract Background Endoscopic submucosal dissection (ESD) of residual or locally recurrent (RLR) colonic lesions after previous endoscopic mucosal resection (EMR) is an attractive but challenging technique. The present study aimed to evaluate the effectiveness and safety of ESD with double clip and rubber band traction (DCT-ESD) of RLR colonic lesions. Methods We retrospectively analyzed all consecutive DCT-ESD procedures for RLR colonic lesions (rectum excluded) performed in two French centers. The frequency of en bloc and R0 resections, procedure speed, additional surgery, and complications were evaluated. R0 resection was also used to investigate the learning curve. Results Among the 53 resections, 49 (92.5 %) were performed en bloc and 42 (79.2 %) achieved R0. The median procedure speed was 21 mm2/min. There were four (7.5 %) intraoperative perforations and one delayed bleeding; these were successfully treated endoscopically. There was no salvage surgery for complications. The R0 rate increased from 16/26 (61.5 %) for the first 26 procedures to 26/27 (96.3 %, P = 0.002) for the last 27 procedures. Conclusions DCT-ESD appears to be a safe and effective treatment for RLR colonic lesions after EMR.
Brain‐derived neurotrophic factor fused with a collagen‐binding domain inhibits neuroinflammation and promotes neurological recovery of traumatic brain injury mice via TrkB signalling

As one of the vital nutrient factors in central nervous system (CNS), brain‐derived neurotrophic factor (BDNF) can significantly attenuate neuron damage and promote neurogenesis. Nevertheless, little research has been conducted on regulating the effect of BDNF on the inflammatory response after traumatic brain injury (TBI).
Protocols for Enzymatic Fluorometric Assays to Quantify Phospholipid Classes

Phospholipids, consisting of a hydrophilic head group and two hydrophobic acyl chains, are essential for the structures of cell membranes, plasma lipoproteins, biliary mixed micelles, pulmonary surfactants, and extracellular vesicles. Beyond their structural roles, phospholipids have important roles in numerous biological processes. Thus, abnormalities in the metabolism and transport of phospholipids are involved in many diseases, including dyslipidemia, atherosclerosis, cholestasis, drug-induced liver injury, neurological diseases, autoimmune diseases, respiratory diseases, myopathies, and cancers. To further clarify the physiological, pathological, and molecular mechanisms and to identify disease biomarkers, we have recently developed enzymatic fluorometric assays for quantifying all major phospholipid classes, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylinositol, phosphatidylglycerol + cardiolipin, and sphingomyelin. These assays are specific, sensitive, simple, and high-throughput, and will be applicable to cells, intracellular organelles, tissues, fluids, lipoproteins, and extracellular vesicles. In this review, we present the detailed protocols for the enzymatic fluorometric measurements of phospholipid classes in cultured cells.
A Newly Recognized Pairing Mechanism of the α- and β-Chains of the Chicken Peptide–MHC Class II Complex

Key Points The chicken pBL2*019:01 structure reveals a conserved α- and β-chain–pairing mechanism. The variable β1 domain of chicken MHC-II determines peptide-presentation profiles. The interaction between pBL2*019:01 and CD4 differs from the corresponding pMHC-II. Visual Abstract MHC class II (MHC-II) molecules play a crucial role in cellular and humoral immunity by forming peptide–MHC-II (pMHC-II) complexes. The three-dimensional structures of pMHC-II complexes have been well resolved in humans and mice. However, there is no structural information for pMHC-II complexes in nonmammals. In chickens, there are two closely related and highly polymorphic β-chains and one monomorphic α-chain, and the mechanism by which one monomorphic α-chain combines with two polymorphic β-chains to form a functional heterodimer remains unknown. In this study, we report the crystal structure of a chicken pMHC-II complex (pBL2*019:01) at 1.9-Å resolution as the first nonmammalian structure of a pMHC-II complex. The structure reveals an increase in hydrogen bonding between the α and β main chains at the central interface that is introduced by the insertion of four residues in the α-chain. The residues in the β-chain that form hydrogen bonds with the α-chain are conserved among all β alleles. These structural characteristics explain the phenomenon of only one BLA allele without sequence variation pairing with highly diverse BLB alleles from two loci in the genome. Additionally, the characteristics of the peptide in the peptide-binding groove were confirmed. These results provide a new understanding of the pairing mechanism of the α- and β-chains in a pMHC-II complex and establish a structural principle to design epitope-related vaccines for the prevention of chicken diseases.
Pressure engineering of the Dirac fermions in quasi-one-dimensional Tl2Mo6Se6

Topological band dispersions other than the standard Dirac or Weyl fermions have garnered the increasing interest in materials science. Among them, the cubic Dirac fermions were recently proposed in the family of quasi-one-dimensional (q-1D) conductors A2Mo6X6 (A = Na, K, In, Tl; X = S, Se, Te), where the band crossing is characterized by a linear dispersion in one k-space direction but the cubic dispersion in the plane perpendicular to it. It is not yet clear, however, how the external perturbations can alter these nontrivial carriers and ultimately induce a new distinct quantum phase. Here we study the evolution of Dirac fermions, in particular the cubic Dirac crossing, under external pressure in the representative q-1D Tl2Mo6Se6 via the first-principles calculations. Specifically, it is found that the topological properties, including the bulk Dirac crossings and the topological surface states, change progressively under pressure up to 50 GPa where it undergoes a structural transition from the hexagonal phase to body-centered tetragonal phase. Above 50 GPa, the system is more likely to be topologically trivial. Further, we also investigate its phonon spectra, which reveals a gradual depletion of the negative phonon modes with pressure, consistent with the more three-dimensional Fermi surface in the high-pressure phase. Our work may provide a useful guideline for further experimental search and the band engineering of the topologically nontrivial fermions in this intriguing state of matter.
Problematic Facebook Use and Problematic Video Gaming Among Female and Male Gamers

The development of modern technologies has facilitated positive functioning in various aspects of everyday life. However, in addition to positive changes, there are also issues related to problematic behavior associated with new technologies and new media, such as problematic Facebook use (PFU) and problematic video gaming (PVG). Therefore, the purpose of this study was to present the specificity of these problematic behaviors in a group of gamers and determine their predictors and interrelatedness. In addition, the aim was to analyze the differences between male and female gamers. The study comprised 1,270 gamers (684 female gamers; age range from 15 to 34 years; M = 19.17 years; SD = 2.91 years). The intensity of PFU was assessed using the Facebook Intrusion Scale, and intensity of PVG was assessed using the Problem Video Game Playing Questionnaire. Results showed that 6.4% of females had high levels of PFU compared to 3.1% of males, and that 1.8% of females had high levels of PVG compared to 5.8% of males. Structural equation modeling showed different predicators for problematic internet use and PVG, despite the correlation between both problematic behaviors. These findings enable better understanding of the relationship between PVG and PFU among gamers and differences between female and male gamers.
Development, optimization and validation of an absolute specific assay for active myeloperoxidase (MPO) and its application in a clinical context: role of MPO specific activity in coronary artery disease

Abstract Background Myeloperoxidase (MPO) is an enzyme with a recognized prognostic role in coronary artery disease (CAD), which is also emerging as a promising biomarker for cardiac risk stratification. However, the lack of a consensus method for its quantification has hindered its implementation in clinical practice. The aim of our work was to optimize an absolute sensitive assay for active MPO without external standards, to validate the method in the clinical context of CAD patients, and to estimate the enzyme specific activity. Methods In order to determine the MPO concentration using fluorescence readings, this ELISA assay exploits the activity of the enzyme recognized by specific antibodies. The assay was validated in a small cohort of patients that included: healthy subjects (n=60); patients with acute myocardial infarction (AMI, n=25); patients with stable CAD (SCAD, n=25) and a concomitant chronic obstructive pulmonary disease (COPD). Then, total MPO concentration and specific activity (activity/total MPO) were determined. Results The assay showed an intra- and inter-assay coefficient of variation of 5.8% and 10.4%, respectively, with a limit of detection (LoD) of 0.074 μU. Both AMI and SCAD patients had higher active and total MPO than controls (p<0.0001 and p<0.01, respectively). The specific activity of MPO was higher in SCAD patients compared to both controls and AMI (p<0.0001). Conclusions The study presents a robust and sensitive method for assaying MPO activity in biological fluids with low variability. Moreover, the determination of the specific activity could provide novel insight into the role of MPO in cardiovascular diseases (CVDs).
DeepRF: Ultrafast population receptive field mapping with deep learning

Population receptive field (pRF) mapping is an important asset for cognitive neuroscience. The pRF model is used for estimating retinotopy, defining functional localizers and to study a vast amount of cognitive tasks. In a classic pRF, the cartesian location and receptive field size are modeled as a 2D Gaussian kernel in visual space and are estimated by optimizing the fit between observed responses and predicted responses. In the standard framework this is achieved using an iterative gradient descent algorithm. This optimization is time consuming because the number of pRFs to fit (e.g., fMRI voxels) is typically large. This computation time increases further with the complexity of the pRF model (e.g., adding HRF parameters, surround suppression and uncertainty measures). Here, we introduce DeepRF, which uses deep convolutional neural networks to estimate pRFs. We compare the performance of DeepRF with that of the conventional method using a synthetic dataset for which the ground truth is known and an empirical dataset. We show that DeepRF achieves state-of-the-art performance while being more than 3 orders of magnitude faster than the conventional method. This enables easier and faster modeling of more complex pRF models, resolving an important limitation of the conventional approach.
Diagnostic Validity of Digital Imaging Fiber-Optic Transillumination (DIFOTI) and Near-Infrared Light Transillumination (NILT) for Caries in Dentine

The objective of the study is to analyse the available evidence for the validity of the transillumination method in the diagnosis of interproximal caries. Bibliographic searches were carried out in three data bases (PubMed, Embase, Scopus) with the key words “Transillumination AND caries”. A total of 11 studies were selected for the qualitative analysis and meta-analysis. In the qualitative analysis, both in vivo and in vitro studies were included. The gold standards were tomography, digital radiography, and clinical visual diagnosis. The meta-analysis determined the sensitivity, specificity, and area below the ROC curve relative to the transillumination method in the diagnosis of caries in dentine. Meta-analysis results obtained for transillumination gave a sensitivity value of 0.69 (confidence interval: 0.54–0.81), a specificity value of 0.89 (confidence interval: 0.61–0.98), while giving an AUC value of 0.79 (confidence interval: 0.67–0.87). Transillumination is a method offering moderate validity in the diagnosis of carious lesions in dentine, there is no strong evidence that may enable us to affirm that transillumination may fully substitute X-rays in the complementary diagnosis of carious lesions
Detection of variants with reduced baloxavir marboxil susceptibility after treatment of children with influenza A during the 2018/2019 influenza season.

During the 2018-2019 influenza seasons, we detected reduced baloxavir marboxil (baloxavir) susceptible variants with I38S or I38T amino acid substitutions on the PA subunit of influenza virus RNA polymerase in 7 of 18 baloxavir treated children and found that virus titer rebounded in some of these children with variants. We also found fever durations to be similar between patients with or without the variants, but the patients with variants shed the virus 3 days longer and took longer to improve clinical symptoms than those without variants. The emergence of these variants should be monitored during future influenza seasons.
Effect of Hip Joint Position on Electromyographic Activity of the Individual Hamstring Muscles During Stiff-Leg Deadlift.

Kawama, R, Takahashi, K, and Wakahara, T. Effect of hip joint position on electromyographic activity of the individual hamstring muscles during stiff-leg deadlift. J Strength Cond Res XX(X): 000-000, 2020-This study investigated the effect of hip joint position on the activity level of individual hamstring muscles during stiff-leg deadlift. Fourteen male collegiate sprinters performed stiff-leg deadlift in the adducted (ADD), neutral (NT), abducted (ABD), internally rotated by 20° (IN20), and externally rotated positions by 20° (EX20) and by 40° (EX40) of the hip joint. Surface electromyogram (EMG) was recorded from the proximal and distal regions of the biceps femoris long head (BFlh), semitendinosus (ST), and semimembranosus (SM). Root mean square value of EMG (RMS-EMG) data was calculated for the concentric and eccentric phases of deadlift and was normalized by RMS-EMG during maximal voluntary contraction of isometric knee flexion as an activity level. Results revealed that the activity level of BFlh during the concentric phase was higher in EX20 (p = 0.008, difference = 6.3%) and EX40 (p = 0.001, difference = 9.4%) than in NT. Semimembranosus showed a higher activity level in IN20 than in EX40 during the concentric (p = 0.004, difference = 4.3%) and eccentric phases (p = 0.023, difference = 4.1%). In addition, the activity level was higher in ABD than in NT for BFlh (p = 0.015, difference = 4.6%), ST (p = 0.047, difference = 3.8%), and SM (p = 0.005, difference = 3.9%) during the concentric phase of deadlift. In conclusion, the deadlift in the hip-abducted position requires high activation of the individual hamstrings and that in the hip externally and internally rotated positions needs high activation of BFlh and SM, respectively.
Autism Spectrum Disorder Diagnostic System Using HOS Bispectrum with EEG Signals

Autistic individuals often have difficulties expressing or controlling emotions and have poor eye contact, among other symptoms. The prevalence of autism is increasing globally, posing a need to address this concern. Current diagnostic systems have particular limitations; hence, some individuals go undiagnosed or the diagnosis is delayed. In this study, an effective autism diagnostic system using electroencephalogram (EEG) signals, which are generated from electrical activity in the brain, was developed and characterized. The pre-processed signals were converted to two-dimensional images using the higher-order spectra (HOS) bispectrum. Nonlinear features were extracted thereafter, and then reduced using locality sensitivity discriminant analysis (LSDA). Significant features were selected from the condensed feature set using Student’s t-test, and were then input to different classifiers. The probabilistic neural network (PNN) classifier achieved the highest accuracy of 98.70% with just five features. Ten-fold cross-validation was employed to evaluate the performance of the classifier. It was shown that the developed system can be useful as a decision support tool to assist healthcare professionals in diagnosing autism.
Theoretical Studies of Photophysical Properties of D−π−A−π−D-Type Diketopyrrolopyrrole-Based Molecules for Organic Light-Emitting Diodes and Organic Solar Cells

A series of D–π–A diketopyrrolopyrrole(DPP)-based small molecules were designed for organic light-emitting diode(OLEDs) and organic solar cell(OSCs) applications. Applying the PBE0/6-31G(d,p) method, the ground state geometry and relevant electronic properties were investigated. The first excited singlet state geometry and the absorption and fluorescent spectra were simulated at the TD-PBE0/6-31G(d,p) level. The calculated results revealed that the photophysical properties were affected through the introduction of different end groups. Furthermore, the electronic transitions corresponding to absorption and emission exhibited an intramolecular charge transfer feature. Our results suggest that the designed molecules acted not only as luminescent for OLEDs, but also as donor materials in OSCs. Moreover, they can also be used as potential electron transfer materials for OLEDs and OSCs.
Characteristics of and Factors Influencing College Nursing Students' Willingness to Utilize mHealth for Health Promotion

More than half of practicing nurses have suboptimal physical or mental health. Impaired health is associated with a 76% higher likelihood that nurses will make medical errors. Improving the health habits of nursing students is essential to shaping and sustaining health prior to joining the workforce. Technology such as mobile health applications holds great promise in facilitating behavioral change and encouraging healthy habits in nursing students. Identifying the predictors of willingness to use mobile health is essential to creating mobile health applications that will engage nursing students and promote sustainable usage. Evaluation of psychological, attitudinal, and health-related correlates of mobile health can highlight predictors of willingness to use mobile health, which can influence nursing students' utilization and long-term engagement with mobile health applications. Analysis of these correlates shows that psychological attributes, such as hope, play a role in the willingness to use and may facilitate engagement in the utilization of a mobile health application. Development of a mobile health application that increases hope and helps establish healthy habits may enable nursing students to remain healthy throughout their lives, creating a new generation of happier, healthier nurses and, ultimately, improving safety for patients under their care.
Life History and Host Preference of Trichopria drosophilae from Southern China, One of the Effective Pupal Parasitoids on the Drosophila Species

This study aims to evaluate several life-history traits of a T. drosophilae population from southern China and its parasitic preference of three Drosophila species. For mated T. drosophilae females, the mean oviposition and parasitization period were 27.20 and 37.80 d, respectively. The daily mean parasitization rate was 59.24% per female and the lifetime number of emerged progeny was 134.30 per female. Trichopria drosophilae females survived 37.90 and 71.61 d under host-provided and host-deprived conditions, respectively. To assess the potential for unmated reproduction in T. drosophilae, the mean oviposition and parasitization period of unmated females was 22.90 and 47.70 d, respectively. They had a daily mean parasitization rate of 64.68%, produced a total of 114.80 offspring over their lifetime, and survived 52 d. Moreover, T. drosophilae showed a preference towards D. suzukii based on the total number of emerged offspring under a choice test. Our findings indicate that T. drosophilae from southern China appears to be suitable for the control of D. suzukii in invaded areas, due to its reproductive potential.