Miracle-dz/UniFAR-FTUs huggingface dataset:
Multiagent System-Based Integrated Design of Security Control and Economic Dispatch for Interconnected Microgrid Systems

Hybrid and intermittent characteristics of the distributed energy resources (DERs) bring great challenges to the security control and economic dispatch (ED) of the microgrids. To bypass these hurdles, this article proposes a multiagent system-based integrated design of security control and ED to guarantee the effective and economical operation of the interconnected microgrids. First, a hierarchical control scheme is constructed by two-level unit agents, in which the switching control and dynamic regulation are fully implemented with the corresponding hybrid behaviors based on the differential hybrid Petri-net (DHPN) model. Based on the DHPN model, a novel dynamic ED integrated with security control is proposed to overcome the issues that cannot be solved in conventional models. Furthermore, to reduce the computational complexity and unified the mathematical model of the DERs, the inverter-based power control strategy is converted to a predictive control model which can be decomposed into several subsystems. In the optimization process, all the subsystems are implemented in a fully distributed, communication free, and rolling optimization manner based on the distributed model predictive control (DMPC). The validity of the proposed design is demonstrated according to the simulation results in case studies.
Comparative tolerability of targeted therapies in pulmonary hypertension

Introduction The objective of this study was to estimate the safety profile of pulmonary hypertension-specific therapies using placebo-controlled and active comparator trials. Material and methods The search corpus comprised Medline, Scopus, Embase and Clinical Trials databases. A systematic review and meta-analysis was performed to assess the relative risk of severe events and discontinuations as well as of adverse drug reactions (ADRs) classified into 26 categories and 21 subcategories defined by the Medical Dictionary for Regulatory Activities (MedRA). Results Pulmonary hypertension-specific therapies had the greatest effect on such events as flushing and headache as well as jaw pain, limb pain and myalgia or gastrointestinal disorders. The relative risk for ADRs in patients receiving monotherapy (vs. placebo/supportive therapies) and combined regimens (vs. monotherapy) was significantly increased. The risk of cessation for the combined regimen was slightly higher (Qinter-group, p = 0.0778). Such ADRs as blood and lymphatic system disorders with the anemia subgroup, gastrointestinal disorders with diarrhea and nausea subgroups, respiratory and thoracic diseases or nervous system disorders with headache tended to occur more often in combination regimens as compared to monotherapy. Conclusions About half of the main categories and subcategories of adverse reactions according to MedRA were associated with a relatively high frequency and hazard ratio. Their risk can be increased when combination regimens are used, especially.
DOA Estimation With Small Snapshots Using Weighted Mixed Norm Based on Spatial Filter

<inline-formula><tex-math notation="LaTeX">$\ell _{2,1}$</tex-math></inline-formula>-norm penalized compressive sensing (CS) is utilized to improve the performance of DOA estimation with small snapshots recently. However, the existing CS-based methods are not robust to the noise. In this article, we propose a CS-based DOA estimation using a novel weighted <inline-formula><tex-math notation="LaTeX">$\ell _{2,1}$</tex-math></inline-formula>-norm penalty. A spatial filter which can roughly “clean up” or eliminate the signals coming from the directions of the true sources is constructed. Thus, the space spectrum of the spatial filter can work as a weighting matrix to adjust the sparse penalty automatically. A new weighted <inline-formula><tex-math notation="LaTeX">$\ell _{2,1}$</tex-math></inline-formula>-norm penalty based on this spatial filter is then proposed for DOA estimation. Simulation results demonstrate the effectiveness and efficiency of the proposed algorithm.
Application of Wireless Network Positioning Technology Based on GPS in Geographic Information Measurement

: Based on the analysis of the advantages and disadvantages of GPS positioning system in practical application, this paper proposes the combination of wireless network positioning technology and GPS positioning system to overcome the low accuracy of GPS positioning system in the case of occlusion. This paper introduces in detail the principle of the application of wireless network positioning technology based on GPS positioning system in geographic information measurement, and illustrates its practical application in production by taking coal mine positioning as an example.
A 28-W, −102.2-dB THD+N Class-D Amplifier Using a Hybrid ΔΣM-PWM Scheme

This article presents a 28-W class-D amplifier for automotive applications. The combination of a high switching frequency and a hybrid multibit <inline-formula> <tex-math notation="LaTeX">$\Delta \Sigma \text{M}$ </tex-math></inline-formula>-PWM scheme results in high linearity over a wide range of output power, as well as low AM-band EMI. As a result, only a small (150-kHz cutoff frequency), and thus low-cost, <italic>LC</italic> filter is needed to meet the CISPR-25 EMI average limit (150 kHz–30 MHz) with 10-dB margin. At 28-W output power, the proposed amplifier achieves 91% efficiency while driving a 4-<inline-formula> <tex-math notation="LaTeX">$\Omega $ </tex-math></inline-formula> load from a 14.4-V supply. It attains a peak THD+N of 0.00077% (−102.2 dB) for a 1-kHz input signal.
Possible zoonotic viral threats associated with bats in southern Ukraine

Possible zoonotic viral threats associated with bats in southern Ukraine. — Yurchenko, O. , Dubina, D. , Sokolovskyi, D. , Gaidash, O. — The paper is devoted to evaluation of some bat species inhabiting Ukraine as potential reservoir hosts of highly dangerous viruses including lyssaviruses, MERS-CoV-related coronaviruses, and arboviruses. Repeated catches of bats by a domestic cat were described. Laboratory examination of the caught bats did not detect infection with coronaviruses or arboviruses such as West Nile, tick-borne encephalitis, Crimean-Congo hemorrhagic fever, Tribec and Uukuniyemi viruses. The analysis of the literature showed the possibility of persistence of dangerous viruses among examined bat species. The fact that domestic cats may prey on bats that are potential reservoir hosts of dangerous viruses should be considered as a risk factor for infection of humans and cats with lyssaviruses causing rabies, and infection of humans with coronaviruses that may be associated with severe respiratory diseases.
IoT Guard: Usable Transparency and Control Over Smart Home IoT Devices

Reassembler -firstBlock: DataBlock +addNewBlock(seq, data) DataBlock +next: DataBlock +previous: DataBlock +data * -isFragment(IpPacket) -getOrCreateConnection(IpPacket) -reassembleFragment(IpPacket) * +sequenceNumber DnsAnalyzer HttpHostAnalyzer TlsRecordAnalyzer TlsHandshakeProtocolParser +deliver(PacketData) ClientHelloMessageParser
Genetically distinct clinical subsets, and associations with asthma and eosinophil abundance, within Eosinophilic Granulomatosis with Polyangiitis

Eosinophilic granulomatosis with polyangiitis (EGPA: formerly Churg-Strauss syndrome) is a rare inflammatory disease of unknown cause. 30% of patients have anti-neutrophil cytoplasm antibodies (ANCA) specific for myeloperoxidase (MPO). We performed a genome-wide association study (GWAS) of EGPA, testing 7.5 million genetic variants in 684 cases and 6,838 controls. Case-control analyses were performed for EGPA as a whole, and stratified by ANCA. To increase power, we used a conditional false discovery rate method to leverage findings from GWASs of related phenotypes. In total, 11 variants were associated with EGPA, two specifically with ANCA-negative EGPA, and one (HLA-DQ) with MPO+ANCA EGPA. Many variants were associated with asthma, eosinophilic and immune-mediated diseases and, strikingly, nine were associated with eosinophil count in the general population. Through Mendelian randomisation, we show that a primary tendency to eosinophilia underlies EGPA susceptibility. We demonstrate that EGPA comprises two genetically and clinically distinct syndromes, with ANCA-negative EGPA genetically more similar to asthma. MPO+ ANCA EGPA is an eosinophilic autoimmune disease sharing certain clinical features and an MHC association with MPO+ ANCA-associated vasculitis, while ANCA-negative EGPA may instead have a mucosal/barrier dysfunction origin. Five identified candidate genes are targets of therapies in development, supporting their exploration in EGPA.
GoT: Decreasing DCC Queuing for CAM Messages

Vehicular networks use Decentralized Congestion Control (DCC) mechanisms to operate effectively, but this mechanism may introduce queuing delays. Freshness of Cooperative Awareness Messages (CAMs) is critical for their usefulness. In this letter we explore how the presence of other types of traffic additional to CAMs, even with lower priorities, has an impact on the freshness of CAM messages due to DCC queuing. Finally, we propose Generate-on-Time (GoT), which is a simple mechanism that reduces DCC queuing delays for CAM messages without introducing any downside in other performance metrics.
META-HEURISTIC MULTI-OBJECTIVE AS AN AFFORDABLE METHOD FOR IMPROVING THE GRATING LOBE IN A WIDE SCAN PHASED ARRAY ANTENNA

In electronic beam scanning, the number of phase shifters is an obvious challenge. So, there are several methods to reduce the number of phase shifters. The aim of this paper is to investigate the use of the meta-heuristic algorithm to lower the grating lobe level in the subarray antenna. Improve the result obtained by group subarray optimization techniques to determine topology and space between elements, and complex optimization of weight, simultaneously. Uniform subarray and random subarray are analyzed in Matlab to determine the coefficient of excitation by the evolutionary algorithm, as well as swarm and hybrid. The results of the simulation are shown; this method leads to radiation pattern without grating lobe in wide scanning angle. It indicates that there is a possibility of obtaining wide electronic scanning with minimum number of phase shifters and improving result.
Distinct spread of DNA and RNA viruses among mammals amid prominent role of domestic species

Emerging infectious diseases arising from pathogen spillover from mammals to humans comprise a substantial health threat. Tracing virus origin and predicting the most likely host species for future spillover events are major objectives in One Health disciplines. However, the species that share pathogens most widely with other mammals, and the role of different wildlife groups in sharing viruses with humans remain poorly identified. To address this challenge, we applied network analysis and Bayesian hierarchical models to a global database of mammal-virus associations. We show that domesticated mammals and some primates hold the most central positions in networks of known mammal-virus associations. We revealed strong evidence that DNA viruses were phylogenetically more host specific than RNA viruses, while the frequencies of sharing viruses among hosts and the proportion of zoonotic viruses in hosts were larger for RNA than DNA viruses. Among entire host-virus networks, Carnivora and Chiroptera hold central positions for mainly sharing RNA viruses with other host species, while network centrality of Primates scored relatively high for sharing DNA viruses. Ungulates hold central positions for sharing both RNA and DNA viruses. Acknowledging the role of domestic species in addition to host and virus traits in patterns of virus sharing is necessary to improve our understanding of virus spread and spillover in times of global change.
Recreational fisheries within the Portofino MPA and surrounding areas (Ligurian Sea, Western Mediterranean Sea)

In the Mediterranean Sea, recreational fishing is a popular activity and anglers catch a significant amount of fish which could represent more than 10% of the total harvesting in a littoral area. The Portofino Marine Protected Area, established in 1999 in the Ligurian Sea (North-Western Mediterranean), traditionally hosts a well-developed recreational fishery. Aim of this study has been to characterize the activities of the local anglers, analysing their annual harvesting within and around the Portofino MPA and the species composition of the catches. This was possible studying data from the mandatory anglers’ logbooks, and through interviews and surveys at sea. In 2015, the 340 checked anglers fished, in average, 1 kg/day, on average, mainly by trolling or handlining systems. Each fisherman, during 25 (± 21) trips, fished approximately 25 kg/year, for a total harvesting of about 8-9 t/year. Seriola dumerili, with 230 kg/year, was the species most caught in terms of biomass. It was followed by Coryphaena hippurus (130 kg/year). In addition, the analysis of catches occurring during local fishing competitions organized off the MPA limits suggested a harvesting capacity for each angler varying between 0.7 and 1.1 kg/angler per day, depending on the used gear (handlining, trolling, spear-guns). Finally, 36% of the anglers claimed to hook often the hard bottom seabed, often losing nylon lines. Consequently, the Management Body of the Portofino MPA has been advised to suspend recreational fishing activities in the most busy areas for a period of two years, calling for a complete removal of the lost fishing gears.
Functional Heterogeneity within the Developing Zebrafish Epicardium

The epicardium is essential during cardiac development, homeostasis and repair and yet fundamental insights into its underlying cell biology, notably epicardium formation, lineage heterogeneity and functional cross-talk with other cell types in the heart, are currently lacking. In this study, we investigated epicardial heterogeneity and the functional diversity of discrete epicardial subpopulations in the developing zebrafish heart. Single-cell RNA-sequencing uncovered three epicardial subpopulations with specific genetic programmes and distinctive spatial distribution within the developing heart. Perturbation of unique gene signatures uncovered distinct functions associated with each subpopulation and established novel epicardial roles in cell adhesion, migration, and chemotaxis as a mechanism for recruitment of leukocytes into the heart. This work elucidates the mutual spatiotemporal relationships between different epicardial subpopulations and assigns unique function to each during cardiac development. Understanding which mechanisms cells employ to establish a functional epicardium and to communicate with other cardiovascular cell types during development will bring us closer to repairing cellular relationships that are disrupted during cardiovascular disease.
Curcuma longa no controle in vitro de Fusarium e produção de MPB de cana-de-açúcar

A disease that is very harmful to the quality of sucrose in sugar cane is Fusarium rot. The work aimed to evaluate the effect of saffron in the in vitro control of Fusarium sp. , Also evaluating the initial development of pre-sprouted sugarcane seedlings treated with saffron and thermotherapy. The experiment was developed at the Phytopathology Laboratory (CCA/ UFPB). Sugar cane of the RB 579 variety was used. The Fusarium sp. was obtained from fragments of the root of the adult plant. Subsequently, health tests were carried out on different parts of the plant. Saffron powder in concentrations 0, 2, 4, 6, 8 and 10g was used as a treatment in the in vitro test. For the emergency test, the treatments were: individualized buds only with superficial disinfestation (control), thermotherapy (52o / 30 min) and immersion in saffron solution for 5 minutes in concentrations 0, 2, 4, 6, 8 and 10g / 100 ml of ADE. Each plant part evaluated presented a different composition of mycoflora, with the Aspergillus genus present in all evaluated organs. The use of saffron was efficient in the in vitro control of Fusarium sp. The use of thermotherapy proved to be an efficient alternative treatment in the physiological and sanitary management for sugarcane grown in a swamp.
Problem-based learning in introductory thermodynamics and fluid mechanics

Problem-based learning (PBL) is a pedagogical approach which aims to create engaged and thorough long-term learning. Often achieved by setting problems centred around a challenge encountered in a discipline representative of a “real world” challenge. In the process of creating a new school of product design (SoPD) and associated degree programme at the University of Canterbury in New Zealand a PBL approach was adopted for a new course in fluid dynamics and thermodynamics, titled “Thermofluids”. Intended to provide students undertaking product design degrees sufficient understanding and appreciation of the material to apply theory to make informed design decisions when dealing with design challenges related to these areas. The school wished to take a novel approach to ensure that students would retain their understanding rather than a more essentialist pedagogical approach to teaching and assessment alone. The first task, to demonstrate their understanding of basic fluid dynamics, was to design and build a “waterclock”. A fluid driven means of marking the passage of time. The second task, to demonstrate their understanding of basic thermodynamics, was to design and build a “solar oven”. PBL challenges are typically open ended and intend to place the students at the centre of the process with educators serving as guiding hands rather than providing prescriptive instruction. The brief for each of these PBL challenges was kept deliberately open in line with PBL theory, the intention being for the students to determine their own parameters for success of the endeavour. However, some alterations were required regarding criteria for the tasks. Important to note that it was the absence of prescriptive criteria which presented an issue, not prescriptive instruction. The various reasons for this are discussed in the paper. Upon completion of the class students were asked to provide a class evaluation. Without prompting the PBL challenges were highlighted as a key positive of the class with students providing commentary that the challenges made the theory feel real and assisted with their understanding of the theory and helped them to prepare for the exam. The paper explores the nature of the PBL pedagogical approach and reflects critically upon the process in this class as a case study, providing insight and proposing theories thereon for further study.
In vitro and in silico identification of the mechanism of interaction of antimalarial drug – artemisinin with human serum albumin and genomic DNA

Artemisinins are secondary metabolites of the medicinal plant Artemisia annua, which has been traditionally used in Chinese medicine. Artemisinins have anti-inflammatory, anticarcinogenic, immunomodulatory, antimicrobial, anthelmintic, antiviral, antioxidant, and other properties. Our preliminary reverse virtual screening demonstrated that the ligand-binding domain of the human glucocorticoid receptor (LBD of hGR) is the optimal target for artemisinin. At the same time, the binding sites for artemisinin with the ligand-binding domain of the human glucocorticoid receptor coincide with those of dexamethasone. However, the pharmacokinetics, pharmacodynamics, and exact molecular targets and mechanisms of action of artemisinin are not well known. In this work, the interaction of artemisinin with human serum albumin (HSA) was studied both in vitro and in silico. The results indicate that artemisinin leads to a decrease in optical absorption and quenching of fluorescence by a static mechanism, which is similar to the effect of dexamethasone. Artemisinin interacts with Drug site I on HSA and forms a hydrogen bond with arginine 218. Retardation of the genomic DNA of sarcoma S-180 cells show that artemisinin does not interact directly with DNA. On the basis of the obtained data, we proposed a hypothetical scheme of the mechanisms of action of artemisinin. Highlights Artemisinin quenches the fluorescence of HSA by a static mechanism. Artemisinin quenches fluorescence of tryptophan. The optimized HSA structure was obtained through molecular dynamics simulations. Artemisinin binds with HSA in Drug site I and forms a hydrogen bond with Arg218. Dexamethasone binds with HSA in Drug site I and forms hydrogen bonds with Arg218, Arg222 and Va1343. A hypothetical scheme of the mechanism of action of Artemisinin was proposed. Graphical Abstract
02. Regional differences in growth rates of Orinoco crocodiles ( Crocodylus intermedius ) from the Venezuelan Llanos

Populations of the Orinoco crocodile (Crocodylus intermedius) have not recovered from past exploitation, and current abundances cannot be used for assessing the suitability of habitats they occupy. Growth constitutes an alternative way of assessing habitat quality. Since 1990, more than 9000 captive-reared Orinoco crocodiles have been released into the Venezuelan Llanos. In the present study, the growth rates of 127 recaptured crocodiles from different regions were compared. All individuals from Middle Cojedes and the Aeolian savannahs grew slower than expected by the von Bertalanffy model, whereas individuals from Caños in the Apure floodplains grew faster than expected. These inferences are corroborated with growth rate measurements for crocodiles under four years of age, which were lowest in Middle Cojedes (average of 14.1 cm/ year) and highest at Caños (43.3 cm/year). Low growth rates can be explained by habitat deterioration due to human activities, and high growth rates in the Caños support that the lower reaches of whitewater rivers offer favourable conditions for the species. Crocodiles in high quality habitats may reach sexual maturity in six years, whereas more than a decade is required in poor-quality habitats.
Activity of robusta coffee on the expression of CRP and MMP-9 against hyperlipidemia

Hyperlipidemia especially LDL accumulation causing inflammation in blood vessel. CRP and MMP-9 are component that triggering in inflammation process. This study to know activity of robusta coffee against hyperlipidemia on this component. This study using male wistar rats were divided into three groups ; normal, hyperlipidemia and that were given coffee with high fat diet groups. Robusta coffee was given 3.6x10-6 m3 by intragastric gavage. Bloodcollection was carried out using infra-orbital for analysis of LDL levels. Furthermore, the experimental animals were sacrificed and coronary arteries were taken for CRP and MMP-9 immunohistochemical staining. Data were analyzed using ANOVA followed LSD test. Results show The highest expression score for CRP and MMP-9 within the hyperlipidemia group was 188.27 ± 1.8 and 277.56 ± 2.1. The decrease in the expression score of CRP and MMP-9 happened within the ones that were given coffee with 59.33 ± 1.5 and 116.7 ± 0.2 each. Results showed that were differences in the expression of CRP andMMP-9 in all groups (p <0.05). In conclusion, activity robusta coffee can decreases the expression of CRP and MMP-9 against hyperlipidemia. Key words: Coronary disease; hyperlipidemia; robusta coffee.