Miracle-dz/UniFAR-FTUs huggingface dataset:
Segurança e biodisponibilidade de suplementos alimentares

Nowadays, new emerging products claiming antioxidant properties are becoming more frequent. However, information about this topic in their labels is usually scarce. In this paper, we analyzed total phenolics, total flavonoids and ascorbic acid contents, as well as DPPH scavenging activity of several commercial samples, namely green tea and other herbal infusions, dietary supplements, and fruit juices, available in the Portuguese market. In general, beverages containing green tea and hibiscus showed higher phenolics contents (including flavonoids) and antioxidant activity than those without these ingredients. A borututu infusion presented the lowest concentrations of bioactive compounds and scavenging activity, due to the low recommended amount of plant to prepare the beverage. Some juices without antioxidant claims in the label presented similar values to those with it.
De novo transcriptome analysis of peduncle necking in cut Rosa hybrida cultivar ‘H30’

Bent-neck or ‘necking’ is a phenomenon often seen in cut roses, whereby the flower head droops due to a bending of the peduncle. Necking is thought to be caused by a blockage of the xylem, either due to an air embolism or an accumulation of contamination, limiting water uptake to the flower head and causing the stem to bend. Despite the use of biocides to reduce contamination levels, necking remains an issue for the cut flower sector and roses continue to die prematurely. As the occurrence of necking varies widely within and between cultivars, a transcriptome analysis of cut Rosa hybrida cultivar ‘H30’ has been carried out to investigate the potential molecular mechanisms involved. Peduncle samples of three stages of necking (straight, <90° and >90°) were sequenced using next generation sequencing to produce over 100 million reads per stage and 203,565 contigs following Trinity de novo assembly. Differential expression analysis revealed nearly 2,000 significant transcripts (p adjust <0.05); providing a new resource for further analysis into the process of necking.
Screening of genetic variability in Turkish maize landraces for protein and starch related traits

Local populations of maize are valuable resources to maintain the genetic variability within the species. Breeding programs in many different countries try to characterize and exploit such germplasm. The objective of this study was to evaluate 192 Turkish maize landraces for their variation in terms of protein ratio, the amino acids that affect the protein quality, starch ratio as well as its fractions. Field experiment was carried out at the Crop Research and Application Unit of CanakkaleOnsekiz Mart University Agricultural Faculty Farm, and used and augmented design with 6 blocks. Each block contained 32 landraces and 7 standard hybrids. Data were collected on protein, lysine, tryptophan, starch, amylose, and amylopectin content. Analysis of variance was run, and genetic calculations were utilized to determine the heritability values. The results suggested that Turkish maize landraces possess a considerable variation for protein and starch traits. The ranges determined for protein, starch, amylose, amylopectin, lysine, and tryptophan were 6.56-16.50%, 56.38-79.63%, 2.09-35.25%, 64.75-97.91%, 0.12-0.93%, and 0.03-0.09%, respectively. The broad sense heritability values for the investigated traits were between 16-53%. Several landraces were detected to be superior to the standard varieties for some traits and considered to be valuable genetic material for the breeding studies to come.
Formation energies of complexes of hydrogen and carbon atoms with vacancy in FCC aluminum from First-principles

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Novel nonlinear control structure for vector control of SPIM drive using BS PCH

This paper presents a novel structure combining the port-controlled Hamiltonian (PCH) and Backstepping (BS) nonlinear control for the vector control of the six-phase induction motor (SPIM). In this new scheme, to improve the outer loop’s robustness, the BS technique using the integral tracking errors action is proposed in the speed and flux controllers design. The advantage of this proposed control law is not to increase the complexity of differential equation resolution due to being not increased system states numbers. To enhance more the performance of SPIM drives (SPIMD), port-controlled Hamiltonian (PCH) scheme is used in the inner current loop controllers. In this proposed PCH current controller, the stabilization of controller is achieved via system passivity. In that, the interconnection and damping matrix functions of PCH system are shaped so that the physical (Hamiltonian) system structure is preserved at the closed loop level and the closed loop energy function is equal to the difference between the physical energy of the system and the energy supplied by the controller. The proposed control design is based on combination PCH and BS techniques improve significantly performance and robustness. The proposed speed control scheme is validated by Matlab-Simulink software.
Active Surveillance of Adverse Events Following Human Papillomavirus Vaccination: Feasibility Pilot Study Based on the Regional Health Care Information Platform in the City of Ningbo, China

Background Comprehensive safety data for vaccines from post-licensure surveillance, especially active surveillance, could guide administrations and individuals to make reasonable decisions on vaccination. Therefore, we designed a pilot study to assess the capability of a regional health care information platform to actively monitor the safety of a newly licensed vaccine. Objective This study aimed to conduct active surveillance of human papillomavirus (HPV) vaccine safety based on this information platform. Methods In 2017, one of China’s most mature information platforms with superior data linkage was selected. A structured questionnaire and open-ended interview guidelines were developed to investigate the feasibility of active surveillance following HPV vaccination using the regional health care information platform in Ningbo. The questionnaire was sent to participants via email, and a face-to-face interview was conducted to confirm details or resolve discrepancies. Results Five databases that could be considered essential to active surveillance of vaccine safety were integrated into the platform starting in 2015. Except for residents' health records, which had a coverage rate of 87%, the data sources covered more than 95% of the records that were documented in Ningbo. All the data could be inherently linked using the national identity card. There were 19,328 women who received the HPV vaccine, and 37,988 doses were administered in 2017 and 2018. Women aged 30-40 years accounted for the largest proportion. Quadrivalent vaccination accounted for 73.1% of total vaccination, a much higher proportion than that of bivalent vaccination. Of the first doses, 60 (60/19,328, 0.31%) occurred outside Ningbo. There were no missing data for vaccination-relevant variables, such as identity card, vaccine name, vaccination doses, vaccination date, and manufacturer. ICD-10 coding could be used to identify 9,180 cases using a predefined list of the outcomes of interest, and 1.88% of these cases were missing the identity card. During the 90 days following HPV vaccination, 4 incident cases were found through the linked vaccination history and electronic medical records. The combined incident rate of rheumatoid arthritis, optic neuritis, and Henoch-Schonlein purpura was 8.84/100,000 doses of bivalent HPV, and the incidence rate of rheumatoid arthritis was 3.75/100,000 doses of quadrivalent HPV. Conclusions This study presents an available approach to initiate an active surveillance system for adverse events following HPV vaccination, based on a regional health care information platform in China. An extended observation period or the inclusion of additional functional sites is warranted to conduct future hypothesis-generating and hypothesis-confirming studies for vaccine safety concerns.
Mechanical Ventilation Stimulates Expression of the SARS-Cov-2 Receptor ACE2 in the Lung and May Trigger a Vicious Cycle

The SARS-Cov-2 virus, which causes COVID 19, uses the cell surface protein ACE2 as receptor for entry into cells. Critically ill COVID-19 patients often require prolonged mechanical ventilation which can cause mechanical stress to lung tissue. In vitro studies have shown that expression of ACE2 in alveolar cells is increased following mechanical stretch and inflammation. Therefore, we analyzed transcriptome datasets of 480 (non-COVID-19) lung tissues in the GTex tissue gene expression database. We found that mechanical ventilation of the tissue donors increased the expression of ACE2 by more than twofold (p<10). Analyses of transcriptomes of mechanically ventilated mice in the GEO database indicate that this alveolar cell response to stretch and inflammation is mediated by the chemokine midkine. Using a novel big knowledge network approach (SPOKE) we also found in transcriptomes of pharmacological perturbations (LINCS) that corticosteroids down-regulate midkine in pulmonal cells, and confirmed this in GEO transcriptomes of animal studies. Thus, mechanical ventilation of patients with COVID-19 pneumonia may eo ipso facilitate viral propagation in the lung, further accelerating the pulmonal pathology that has necessitated mechanical ventilation in the first place. This vicious cycle presents a rationale for the temporary treatment with corticosteroids to modulate the midkine-ACE2 axis in ventilated COVID19 patients and for gentler ventilation protocols.
THE INFLUENCE OF ORGANIZATIONAL JUSTICE AND TRANSFORMATIONAL LEADERSHIP THROUGH JOB SATISFACTION ON ORGANIZATIONAL COMMITMENT

The purpose of this study was to determine the mediation of job satisfaction in a relationship between organizational justice and transformational leadership on organizational commitment. A total of 170 participants who are working in BIAS Yogyakarta have joined this research. Method of collecting data using a questionnaire by conducting regression with analyzing use t-test, F-test, Path analysis with Sobel test. The result of this study found that organizational justice has positive and significant impact on job satisfaction, transformational leadership have positive and significant impact on job satisfaction, organizational justice has negative impact on organizational commitment, transformational leadership have positive and significant impact on organizational commitment, job satisfaction has negative impact on organizational commitment, job satisfaction have mediating effect between organizational justice and organizational commitment, and job satisfaction have mediating effect between transformational leadership and organizational commitment.Kata Kunci: organizational justice, transformational leadership, job satisfaction, organizational commitment
تاثیر محلولپاشی عناصر نانو کلات آهن و منگنز بر تعدادی از صفات کیفی ماش (Vigna Radiata L. Wilczek Parto Variety) تحت تنش کمآبی

به منظور مطالعه اثر محلول‌پاشی نانو کود کلاته آهن و منگنز در کاهش اثرات کمبود آب بر صفات کیفی گیاه ماش رقم پرتو آزمایش بصورت کرت‌های خرد شده بر اساس طرح پایه بلوک‌های کامل تصادفی با سه تکرار درسال زراعی 93-1392در مزرعه تحقیقاتی دانشکده کشاورزی دانشگاه تربیت مدرس انجام شد. تیمارهای آزمایشی در کرت اصلی شامل 3 سطح رژیم آبیاری و در کرت فرعی شامل 10 سطح محلول‌پاشی طی مراحل قطع آبیاری در نظر گرفته شد. نتایج نشان داد که اثر کمبود آب و محلول‌پاشی نانو کلات آهن و منگنز بر اکثر صفات مورد بررسی در سطح احتمال 1% معنی‌دار بود. اعمال تنش کم‌آبی در مرحله رشد رویشی و رشد زایشی موجب کاهش همه‌ی صفات مورد مطالعه بجز میزان رنگیزه کاروتنوئید و پرولین شد. همچنین محلول‌پاشی سطوح مختلف نانو کلات آهن و منگنز در مراحل رشد رویشی و زایشی موجب افزایش میزان کلروفیل و کاروتنوئید گردید. در نهایت اثر متقابل تنش کمبود آب و محلول‌پاشی نانو کلات آهن و منگنز بر اکثر صفات مورد بررسی در سطح احتمال 1‌% معنی‌دار بود.
Static/dynamic real-time legacy software migration: a comparative analysis

Evolution to next generation embedded systems is shortening the obsolescence period of the underlying hardware. As this happens, software designed for those platforms (a.k.a., legacy code), that might be functionally correct and validated code, may be lost in the architecture and peripheral change. As embedded systems often have Real-Time (RT) computing constraints, the legacy code retargeting issue directly affects RT systems. Binary translation techniques have been widely applied for legacy code migration. However, there are just a few works that consider RT legacy code. Therefore, this paper presents a static and a dynamic binary migration approach (based on QEMU and Rev.ng respectively) and analyzes and compares their suitability as RT code migration solutions. The comparison shows that among the proposed solutions, the static is the most appropriate for short-running RT legacy code, since it ensures lower translation overhead and a more deterministic timing behavior. Instead, the dynamic approach might be a suitable solution for RT legacy code with long periods (over 0.01 s) and mainly composed of complex floating point computations, since the dynamic translation and optimization overhead is not that significant on long-running benchmarks and the static translation implies a great slowdown on benchmarks containing floating point operations.
Multiplex Vision: Understanding Information Transfer and F-Formation With Extended 2-Way FOV

Research in sociology shows that effective conversation relates to people’s spatial and orientational relationship, namely the proxemics (distance, eye contact, synchrony) and the F-formation (orientation and arrangement). In this work, we introduce novel conversational paradigms that effects conventional F-formation by introducing the concept of multi-directional conversation. Multiplex Vision is a head-mounted device capable of providing a 360° field-of-view (FOV) and facilitating multi-user interaction multi-directionally, thereby providing novel methods on how people can interact with each other. We propose 3 possible new forms of interactions from our prototype: one-to-one, one-to-many, and many-to-many. To facilitate them, we manipulate 2 key variables, which are the viewing parameter and the display parameter. To gather feedback for our system, we conducted a study to understand information transfer between various modes, as well as a user study on how different proposed paradigms effect conversation. Finally, we discuss present and future use cases that can benefit from our system.
Test-case-based Code Navigation in Dynamically Typed Programming Languages

Providing useful support for developers to understand the source code in maintenance tasks is a challenge. It is even more complicated when dealing with dynamically typed languages, because data types are not explicitly specified. In particular, the construction of call graphs (CGs) is compromised, and they are the basis to build code navigation tools, which are essential for code understanding. To address this problem, we present a technique that leverages automated test cases to build CGs. The technique uses both static and dynamic information and includes offline and online stages to guarantee performance while developers are coding. Our technique is evaluated with developers of a proprietary project, which shows that it increases the precision of CGs.
Fish dispersal in flowing waters: A synthesis of movement- and genetic-based studies

Enhancing our understanding of fish dispersal is central to the success of modern‐day conservation efforts in freshwater ecosystems. However, methods seeking to estimate dispersal are diverse; ranging from direct estimation of individual movements, computation of dispersal kernels, to indirect assessment using measures of gene flow across riverscapes. An important question is whether results from these different approaches provide a consistent picture of the spatial scales of dispersal. Here, we performed a review and meta‐analysis of the literature reporting both individual movements and genetic data to characterize patterns of dispersal for riverine fishes globally. Across all the studies considered (Ndᵢᵣₑcₜ = 206; Nᵢₙdᵢᵣₑcₜ = 205), our results suggest restricted magnitudes of dispersal for riverine fishes, but highlight a large heterogeneity among species, taxonomic orders and geographies. For instance, we found that the maximum parent–offspring dispersal distances varied from 69 m to 1,086 km (median = 12 km; Nₛₚₑcᵢₑₛ = 107), whereas the dispersal spread derived from isolation‐by‐distance slopes (σIBD) from genetic data ranged from 19 m to 250 km (median = 1 km; Nₛₚₑcᵢₑₛ = 56). Comparisons of species‐specific values also revealed significant and positive relationships between direct and indirect estimates of dispersal distances, indicating that organismal movement ability often translates into effective transmission of genes. Finally, this global overview pointed to important geographic and taxonomic disparities in the study of dispersal for riverine fishes. We thus encourage researchers to broaden the taxonomic and geographical scope of future investigations and identify emerging research frontiers where new scientific efforts are needed.
Leukemia-on-a-chip: Dissecting the chemoresistance mechanisms in B cell acute lymphoblastic leukemia bone marrow niche

Ma et al. dissected the heterogeneous leukemia chemoresistance mechanisms using a leukemia-on-a-chip bone marrow niche model. B cell acute lymphoblastic leukemia (B-ALL) blasts hijack the bone marrow (BM) microenvironment to form chemoprotective leukemic BM “niches,” facilitating chemoresistance and, ultimately, disease relapse. However, the ability to dissect these evolving, heterogeneous interactions among distinct B-ALL subtypes and their varying BM niches is limited with current in vivo methods. Here, we demonstrated an in vitro organotypic “leukemia-on-a-chip” model to emulate the in vivo B-ALL BM pathology and comparatively studied the spatial and genetic heterogeneity of the BM niche in regulating B-ALL chemotherapy resistance. We revealed the heterogeneous chemoresistance mechanisms across various B-ALL cell lines and patient-derived samples. We showed that the leukemic perivascular, endosteal, and hematopoietic niche-derived factors maintain B-ALL survival and quiescence (e.g., CXCL12 cytokine signal, VCAM-1/OPN adhesive signals, and enhanced downstream leukemia-intrinsic NF-κB pathway). Furthermore, we demonstrated the preclinical use of our model to test niche-cotargeting regimens, which may translate to patient-specific therapy screening and response prediction.
System simulation with PULP virtual platform and SystemC

Driven by performance, power and energy requirements compute platforms evolved from single-core homogeneous into highly parallel heterogeneous architectures. These architectures use different CPUs, GPUs, accelerators, interconnects, memories, etc., and target diverse applications creating avast design space. Moreover, ever-growing security concerns leverage the adoption of open source silicon designs and tools, specially those with collaborative research and engineering efforts from industry and academia to develop and maintain for the long term. In this context, RISC-V based solutions are an outstanding choice and virtual platforms are essential for a fast design cycle. However, simulation frameworks often do not provide off-the-shelf interoperability hindering the reusability of existing models. In this paper, we present for the first time a coupling of the PULP virtual platform, which provides manycore RISC-V accelerators in a feature-rich simulation environment, with SystemC/TLM-2.0, a de facto standard in industry that is also largely used in the academia. Furthermore, we evaluate the coupling of simulation engines and demonstrate its usefulness in a case study.
VRSketchPen: Unconstrained Haptic Assistance for Sketching in Virtual 3D Environments

Accurate sketching in virtual 3D environments is challenging due to aspects like limited depth perception or the absence of physical support. To address this issue, we propose VRSketchPen – a pen that uses two haptic modalities to support virtual sketching without constraining user actions: (1) pneumatic force feedback to simulate the contact pressure of the pen against virtual surfaces and (2) vibrotactile feedback to mimic textures while moving the pen over virtual surfaces. To evaluate VRSketchPen, we conducted a lab experiment with 20 participants to compare (1) pneumatic, (2) vibrotactile and (3) a combination of both with (4) snapping and no assistance for flat and curved surfaces in a 3D virtual environment. Our findings show that usage of pneumatic, vibrotactile and their combination significantly improves 2D shape accuracy and leads to diminished depth errors for flat and curved surfaces. Qualitative results indicate that users find the addition of unconstraining haptic feedback to significantly improve convenience, confidence and user experience.