Miracle-dz/UniFAR-FTUs huggingface dataset:
Selecting most informative contributors with unknown costs for budgeted crowdsensing

Mobile crowdsensing has become a novel and promising paradigm in collecting environmental data. A critical problem in improving the QoS of crowdsensing is to decide which users to select to perform sensing tasks, in order to obtain the most informative data, while maintaining the total sensing costs below a given budget. The key challenges lie in (i) finding an effective measure of the informativeness of users' data, (ii) learning users' sensing costs which are unknown a priori, and (iii) designing efficient user selection algorithms that achieve low-regret guarantees. In this paper, we build Gaussian Processes (GPs) to model spatial locations, and provide a mutual information-based criteria to characterize users' informativeness. To tackle the second and third challenges, we model the problem as a budgeted multi-armed bandit (MAB) problem based on stochastic assumptions, and propose an algorithm with theoretically proven low-regret guarantee. Our theoretical analysis and evaluation results both demonstrate that our algorithm can efficiently select most informative users under stringent constraints.
Methods for Assessing Curvature and Interaction in Mixture Experiments

The terms curvature and interaction traditionally are not defined or used in the context of mixture experiments because curvature and interaction effects are partially confounded due to the mixture constraint that the component proportions sum to 1. Instead, the term nonlinear blending traditionally is defined and used. However, just as the concept of a component effect is defined specifically for mixture experiments, the concepts of curvature and interaction can be also. These special definitions lead to special sets of points for assessing the curvature and interaction of mixture components. An interaction plot for mixture components is obtained by plotting measured or predicted response values at the special points for assessing interaction. Together with response trace (component effects) plots, the new mixture component interaction plots provide for graphically assessing the linear, curvature, and interaction effects of mixture components. These methods provide a more complete picture of how mixture components affect a response, which is useful in formulating mixtures and confirming or extending subject matter knowledge. The special sets of points and the graphical techniques used to assess linear, curvature, and interaction effects are illustrated using two nuclear waste glass examples.
Estimating a Proportion Using Stratified Data From Both Convenience and Random Samples

Estimating the proportion of an attribute present in a population can be challenging when the population is stratified by lots produced by a common manufacturing process and the available data arise from both random and convenience samples. Moreover, all of the lots may not have been sampled. This article proposes a Bayesian methodology for making inferences about a proportion that properly accounts for the potential bias of the convenience samples, the stratification by lots, and the fact that not all of the lots have been sampled. The methodology is illustrated with a simulated population; however, the solution is motivated by a similar, but proprietary, production situation.
A high speed multi-input comparator with clocking-charge based for low-power systems

Currently, a comparison function has been widely used for discrete signal processing. In this study, a novel comparison-cell is presented based on clocking concept. The advantages are that the circuit complexity can be largely reduced and the delay time becomes shorter. The prototype cell is designed for 4-bit comparison cell using Spice simulator. As comparisons with CMOS base, the complexity of proposed cell is reduced to one-third, and the circuit delay can be shortened to half. With a regular design, the prototype of 4/spl times/6 comparison circuit is implemented based on 4-bit basic cell. The chip core is about 0.9mm/sup 2/ using UMC 0.5 /spl mu/m process.
Constraint induced movement therapy for stroke survivors in Jordon: a home-based model

Aims: This article describes a home-based study evaluating the effectiveness of modified constraint induced movement therapy (CIMT) in improving upper limb function in stroke survivors, and compares it with the clinical-based Neurodevelopmental Treatment (NDT) approach. Methods: In this pretest-post-test randomized study, 10 stroke survivors received home-based modified CIMT and eight stroke survivors received conventional NDT rehabilitation. The focus of the CIMT was on the hemiplegic hand, by which the less affected hand was restrained, with structured training for the more affected arm and hand. The intervention was executed two hours a day, seven days a week for two months, in the patients' normal day-care environment. Arm motor function outcomes were evaluated using the Wolf Motor Function Test as a primary outcome measure. The motor activity log, and the Fugl-Meyer Assessment were used as secondary outcome measures. Findings: Stroke survivors in the CIMT group showed a statistically significant impr.
Empowering Farm Women to Reduce Hazards to Family Health and Safety on the Farm

ABSTRACT We describe a unique example of a community participation program to prevent agricultural injury and illness on family farms in two south-central Kentucky counties. Funded by the W. K. Kellogg Foundation, this three-year program builds on existing social networks among farm women and on the traditional role of women as the primary health officers of their families. Twelve influential farm women were recruited as the core group of the Kentucky Partnership for Farm Family Health and Safety in February 1993. Together with technical assistance from two universities, they built a coalition of local farm families, health professionals, businesses, and volunteer agencies. Based on the findings of county-wide surveys of farm women, the Partnership members planned and implemented farm safety training programs, including presentations for over 5,000 school students and at over 100 community events. Another innovative educational tool developed by the women was “photonovels” featuring local people in agricu.
Chaos and Time-Series Analysis

and well organized. Two appendixes provided at the end of the text explain the installation of R and provide a quick tutorial on the use of R. In addition, a handful of exercises are provided at the end of each chapter, the level of which are similar to those in the text of Muller and Fetterman (2002). A “how to” text on R would be a helpful supplement to this text. Overall, Linear Models With R is well written and, given the increasing popularity of R, it is an important contribution.
Big Data for Health

This paper provides an overview of recent developments in big data in the context of biomedical and health informatics. It outlines the key characteristics of big data and how medical and health informatics, translational bioinformatics, sensor informatics, and imaging informatics will benefit from an integrated approach of piecing together different aspects of personalized information from a diverse range of data sources, both structured and unstructured, covering genomics, proteomics, metabolomics, as well as imaging, clinical diagnosis, and long-term continuous physiological sensing of an individual. It is expected that recent advances in big data will expand our knowledge for testing new hypotheses about disease management from diagnosis to prevention to personalized treatment. The rise of big data, however, also raises challenges in terms of privacy, security, data ownership, data stewardship, and governance. This paper discusses some of the existing activities and future opportunities related to big data for health, outlining some of the key underlying issues that need to be tackled.
'Migrating' intraventricular neurocysticercus cyst

This report describes an intraventricular neurocysticercus cyst of the 4th ventricle with consequent hydrocephalus in an adult man. He was managed with anti-helminthic therapy and a 3rd ventriculostomy. Initial imaging showed the cyst within the 4th ventricle. At follow-up imaging a cyst was present in the 3rd ventricle and the 4th ventricle had returned to normal. It is postulated that the cyst ‘migrated\' from the 4th to the 3rd ventricle. South African Journal of Radiology Vol. 11 (1) 2007: pp. 25-27
Roboter oder Therapeut? Welches ist die effektive Behandlungsstrategie für ein Lokomotionstraining nach Schlaganfall?

Methode George Hornby und seine Kollegen aus Chicago führten eine randomisierte kontrollierte Studie durch, die 48 Patienten in einem chronischen Stadium nach Schlaganfall einschloss. Vor der Randomisierung wurden die Studienteilnehmer anhand ihrer Gehgeschwindigkeit in Gruppen von schwerer oder moderater Beeinträchtigung stratifiziert. Alle Patienten waren zu Studienbeginn gehfähig. Sie wurden in 12 Behandlungseinheiten auf dem Laufband trainiert. Das Körpergewicht wurde um 30 – 40 % durch ein Gurtsystem entlastet. Die Patienten der roboterunterstützten Gruppe wurden durch einen Lokomat assistiert. Hierbei führen 2 computerkontrollierte Orthesen die Schritte. In der therapeutisch unterstützten Gruppe wurde – wenn notwendig – das paretische Bein gesetzt. Die untersuchten Variablen waren Gehgeschwindigkeit in der Ebene, Dauer des Gangzyklus, Schrittlängensymmetrie, 6-Minuten-Gehtest, modifiziertes Emory Functional Ambulation Profile, Berg Balance Scale und SF-36.
Protocol of Mensuration to Avaliation of Indicators of Somatic Development of Wistar Rats

Evaluaciones de peso y perimetro cefalico son muy utilizadas para el estudio del crecimiento y desarrollo en humanos. Medidas semejantes, denominadas murinometricas, han sido un recurso eficiente para el estudio de los efectos de manipulaciones nutricionales y farmacologicos sobre el desarrollo somatico en ratas. El objetivo de este trabajo fue describir un metodo de evaluacion que ofrece mayor exactitud en la recoleccion de los datos, en el estudio del desarrollo somatico en ratas Wistar. Fueron realizadas medidas en el eje latero-lateral del craneo (ELLC); eje antero-posterior del craneo (EAPC); eje longitudinal (EL) y largo de la cola (LC), en 60 ratas Wistar, durante el periodo de amamantacion. Se observo, como metodo mas adecuado de medicion, el que se relaciona con puntos anatomicos predefinidos, uso del asta adecuada del instrumento de medida (paquimetro), asi como la precision de su exactitud
Special issue on Massive MIMO

Demand for wireless communications is projected to grow by more than a factor of forty or more over the next five years. A potential technology for meeting this demand is Massive MIMO (also called Large-Scale Antenna Systems, Large-Scale MIMO, ARGOS, Full-Dimension MIMO, or Hyper-MIMO), a form of multiuser multipleantenna wireless which promises orders-of-magnitude improvements in spectral-efficiency over 4G technology, and accompanying improvements in radiated energy-efficiency. The distinguishing feature of Massive MIMO is that a large number of service-antennas - possibly hundreds or even thousands - work for a significantly smaller number of active autonomous terminals. Upsetting the traditional parity between service antennas and terminals in this manner is a game-changer: The simplest multiplexing precoding and decoding algorithms can be nearly optimal, expensive ultra-linear forty-Watt power amplifiers are replaced by many low-power units, and the favorable action of the law of large numbers can greatly facilitate power-control and resource-allocation.
Late cardiac effects of adjuvant chemotherapy in breast cancer survivors treated on Southwest Oncology Group protocol s8897.

PURPOSE The late cardiac effects of adjuvant anthracycline therapy in survivors of early-stage breast cancer have had limited study. Subclinical and clinical cardiac late effects may contribute to added comorbidity over time. PATIENTS AND METHODS We recruited patients treated on Southwest Oncology Group (SWOG) protocol S8897 who had been randomly assigned to adjuvant chemotherapy with or without doxorubicin. Left ventricular ejection fraction (LVEF) was evaluated at 5 to 8 years and 10 to 13 years after treatment randomization. Cardiac risk factors and events were reported by clinicians annually between the two assessments. RESULTS A total of 180 breast cancer survivors from a potential sample of 1,176 patients were entered, 163 patients at 5 to 8 years and 17 additional patients at 10 to 13 years, with 93 longitudinal assessments of LVEF. There was no significant difference in the proportion of women with an LVEF less than 50% at 5 to 8 (cyclophosphamide, doxorubicin, and fluorouracil [CAF] v cyclophosphamide, methotrexate, and fluorouracil [CMF]: 5% v 7%; P = .68) or 10 to 13 years (CAF v CMF: 3% v 0%; P = .16); however, in an exploratory analysis, the mean LVEF in the doxorubicin group was statistically significantly lower in the 5- to 8-year sample (64.8% v 61.4%; P = .01) but not in the 10- to 13-year sample. In the longitudinal analysis, there was no significant deterioration in LVEF. CONCLUSION Women enrolled onto an adjuvant chemotherapy treatment clinical trial for breast cancer were successfully recruited to participate in a research study of the late effects of treatment, although many SWOG institutions and potentially eligible patients chose not to participate. In this selected sample, with up to 13 years of follow-up, exposure to doxorubicin did not increase the likelihood of adverse cardiac effects.
The safety of dose-dense doxorubicin and cyclophosphamide followed by paclitaxel with trastuzumab in HER-2/neu overexpressed/amplified breast cancer.

PURPOSE Dose-dense (dd) doxorubicin and cyclophosphamide (AC) followed by paclitaxel (P) is superior to every 3-weekly AC followed by P. Given the demonstrated cardiac safety for trastuzumab (T) with conventionally scheduled AC followed by P, we tested the safety of dd AC followed by P with T. The primary end point was cardiac safety, and the secondary end points were time to recurrence and overall survival. METHODS Patients with HER-2/neu immunohistochemistry (IHC) 3+ or fluorescent in situ hybridization (FISH)-amplified breast cancer and baseline left ventricular ejection fraction (LVEF) of >or= 55% were enrolled, regardless of tumor size or nodal status. Treatment consisted of AC (60/600 mg/m(2)) x 4 followed by P (175 mg/m(2)) x 4 every 2-weekly with pegfilgrastim (6 mg on day 2) + T x1 year. LVEF by radionuclide scan was obtained at baseline, at months 2, 6, 9, and 18. RESULTS From January 2005 to November 2005, 70 patients were enrolled. The median age was 49 years (range, 27 to 72 years); median LVEF at baseline was 68% (range, 55% to 81%). At month 2 in 70 of 70 patients, the median LVEF was 67% (range, 58% to 79%); at month 6 in 67 of 70 patients, it was 66% (range, 52% to 75%); at month 9 in 68 of 70 patients, it was 65% (range, 50% to 75%); and at month 18 in 48 of 70 patients, it was 66% (range, 57% to 75%). As of December 1, 2007, the median follow-up was 28 months (range, 25 to 35 months). One patient (1%) experienced congestive heart failure (CHF). There were no cardiac deaths. CONCLUSION Dose-dense AC followed by P/T followed by T is feasible and is not likely to increase the incidence of cardiac events compared to established regimens.
A 1 TB/s 1 pJ/b 6.4  ${\rm mm}^{2}/{\rm TB/s}$ QDR Inductive-Coupling Interface Between 65-nm CMOS Logic and Emulated 100-nm DRAM

1 TB/s 1 pJ/b 6.4 mm2 /TB/s QDR inductive-coupling interface between 65-nm complementary metal-oxide-semicon ductor (CMOS) logic and emulated 100-nm dynamic random access memory (DRAM) is developed. BER <;10-10 operation is examined in 1024-bit parallel links. Compared to the latest wired 40-nm DRAM interface, the bandwidth is increased to 32×, and the energy consumption and the layout area are reduced to 1/8 and 1/22, respectively.
Polymorphisms in the putative micro-RNA-binding sites of mesothelin gene are associated with serum levels of mesothelin-related protein

Background Serum mesothelin, also known as soluble mesothelin-related protein (SMRP), reportedly shows increased levels in epithelial-type malignant pleural mesothelioma, but sometimes also arrives at high values in healthy asbestos-exposed subjects. Objectives This study aimed to investigate whether single nucleotide polymorphisms in the 3′untranslated region (3′UTR) of the mesothelin-encoded gene (MSLN) are associated with the SMRP levels measured in serum. Methods The 3′UTR of the mesothelin gene was genotyped in 59 healthy asbestos-exposed subjects, selected on the basis of their SMRP levels. Direct sequencing did not show any new polymorphism, but enabled us to genotype two known SNPs (rs1057147, rs57272256). Differences in the mean values of SMRP in wild-type and variant heterozygote groups were calculated. Results High levels of SMRP in healthy asbestos-exposed subjects were significantly associated with polymorphism rs1057147 (G<A). Regarding rs57272256, there was no statistically significant difference between wild-type and heterozygote groups. Our study suggests that rs1057147 polymorphism can affect mesothelin expression. Although these data need to be confirmed with a larger number of cases, this study warrants further research in order to better understand the relationship between mesothelin polymorphisms and SMRP.
The Epidemiology of Chronic Widespread Pain

SUMMARY Objectives: To discuss some aspects of the epidemiology of widespread pain: case definition, occurrence, and associated characteristics. Findings: The fibromyalgia definition of chronic widespread pain is useful from an epidemiological standpoint because it facilitates comparison between studies. In studies of widespread pain sufferers, back pain and osteoarthritis represent important subgroups. The overall prevalence of widespread pain remains fairly stable but is dynamic with influx from no pain and regional pain groups as efflux to those same groups occurs. The prevalence of widespread musculoskeletal pain is somewhat higher among women than men in the community, but the very high female-to-male ratio among sufferers with fibromyalgia is unexplained. Distress, fatigue, and frequent consultations for disruptive symptoms appear to be risk factors for the development of chronic widespread pain. Conclusions: It may be that “widespreadness” is our best epidemiological measure of the extent of involvement of central pain processes.
The effect of high temperatures on cause-specific mortality in England and Wales

Objectives Several observational studies have suggested an association between high temperatures and all-cause mortality. However, estimates on more specific mortality outcomes are sparse, and frequently assessed in studies using different analytical methods. Methods A time series analysis was performed on 10 regions in England and Wales during the summers (June–September) of 1993–2006. Average percentage linear increases in risk for a 1°C increase in temperature above region-specific thresholds and attributable deaths were computed by cause-specific mortality and age groups (0–64, 65–74, 75–84, 85+). Results There was evidence of increased mortality with heat for almost all cause-of-death groups examined, with an overall increase in all-cause mortality of 2.1% (95% CI 1.6% to 2.6%) for a 1°C rise above the regional heat threshold. Among main causes, the steepest increase in risk was for respiratory mortality (+4.1% (3.5% to 4.8%) per 1°C). It was much smaller for cardiovascular causes (+1.8% (1.2% to 2.5%)) and myocardial infarction (+1.1% (0.7% to 1.5%)), but comparatively high for arrhythmias (+5.0% (3.2% to 6.9%)) and pulmonary heart disease (+8.3% (2.7% to 14.3%)). Among non- cardiorespiratory causes, the strongest effects were for genitourinary (+3.8% (2.9% to 4.7%)) and nervous system (+4.6% (3.7% to 5.4%)) disorders. 33.9% of heat deaths were attributable to cardiovascular causes, 24.7% to respiratory causes and 41.3% to all other causes combined. Conclusions These results suggest that the risk of heat-related mortality is distributed across a wide range of different causes, and that targeting of preventative actions based on pre-existing disease is unlikely to be efficient.
Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer.

PURPOSE Aberrant vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) signaling have been shown to play a role in non-small-cell lung cancer (NSCLC) pathogenesis and are associated with decreased survival. We evaluated the clinical activity and tolerability of sunitinib malate (SU11248), an oral, multitargeted tyrosine kinase inhibitor that blocks the activity of receptors for VEGF and PDGF, as well as related tyrosine kinases in patients with previously treated, advanced NSCLC. PATIENTS AND METHODS Patients with stage IIIB or IV NSCLC for whom platinum-based chemotherapy had failed received 50 mg/d of sunitinib for 4 weeks followed by 2 weeks of no treatment in 6-week treatment cycles. The primary end point was objective response rate (ORR); secondary end points included progression-free survival, overall survival, and safety. RESULTS Of the 63 patients treated with sunitinib, seven patients had confirmed partial responses, yielding an ORR of 11.1% (95% CI, 4.6% to 21.6%). An additional 18 patients (28.6%) experienced stable disease of at least 8 weeks in duration. Median progression-free survival was 12.0 weeks (95% CI, 10.0 to 16.1 weeks), and median overall survival was 23.4 weeks (95% CI, 17.0 to 28.3 weeks). Therapy was generally well tolerated. CONCLUSION Sunitinib has promising single-agent activity in patients with recurrent NSCLC, with an ORR similar to that of currently approved agents and an acceptable safety profile. Further evaluation in combination with other targeted agents and chemotherapy in patients with NSCLC is warranted.
Higher doses of lenalidomide are associated with unacceptable toxicity including life-threatening tumor flare in patients with chronic lymphocytic leukemia.

PURPOSE Lenalidomide is a novel therapeutic agent with uncertain mechanism of action that is clinically active in myelodysplastic syndrome (MDS) and multiple myeloma (MM). Application of high (MM) and low (MDS) doses of lenalidomide has been reported to have clinical activity in CLL. Herein, we highlight life-threatening tumor flare when higher doses of lenalidomide are administered to patients with CLL and provide a potential mechanism for its occurrence. PATIENTS AND METHODS Four patients with relapsed CLL were treated with lenalidomide (25 mg/d for 21 days of a 28-day cycle). Serious adverse events including tumor flare and tumor lysis are summarized. In vitro studies examining drug-induced apoptosis and activation of CLL cells were also performed. RESULTS Four consecutive patients were treated with lenalidomide; all had serious adverse events. Tumor flare was observed in three patients and was characterized by dramatic and painful lymph node enlargement resulting in hospitalization of two patients, with one fatal outcome. Another patient developed sepsis and renal failure. In vitro studies demonstrated lenalidomide-induced B-cell activation (upregulation of CD40 and CD86) corresponding to degree of tumor flare, possibly explaining the tumor flare observation. CONCLUSION Lenalidomide administered at 25 mg/d in relapsed CLL is associated with unacceptable toxicity; the rapid onset and adverse clinical effects of tumor flare represent a significant limitation of lenalidomide use in CLL at this dose. Drug-associated B-cell activation may contribute to this adverse event. Future studies with lenalidomide in CLL should focus on understanding this toxicity, investigating patients at risk, and investigating alternative safer dosing schedules.