Miracle-dz/UniFAR-FTUs huggingface dataset:
Studies of the operator region of the Staphylococcus aureus β-lactamase operon

The repressor proteins BlaI and MecI bind similarly to the bla operator implicated in the regulation of beta-lactamase synthesis in Staphylococcus aureus. BlaI binds to two separate dyads but neither copper-phenanthroline footprinting nor dimethyl sulphate (DMS) methylation protection assays produced any evidence of a change in the geometry of the DNA between the two dyads. It is concluded that BlaI molecules bound at the dyads probably do not cause bending or looping of the intervening DNA. DMS protection assays of BlaI binding to the bla operator in vitro and in vivo gave similar results so that it is tentatively concluded that the in vitro results are an accurate reflection of the in vivo situation. Deletion of the dyad nearest to the blaZ gene resulted in decreased synthesis of the chloramphenicol acetyltransferase reporter protein synthesized from the blaZ promoter/translation initiator. Explanations for this are considered.
Beyond Territorial Innovation Models: The Pertinence of the Territorial Approach

Crevoisier O. Beyond territorial innovation models: the pertinence of the territorial approach, Regional Studies. Research on territorial innovation models (TIMs) has had and still has a considerable impact on innovation studies in a broad range of fields (political economy, geography, sociology, administrative and political science, etc.). This paper suggests that a broader approach – territorial economy – which became structured to a considerable extent thanks to research on innovation, is emerging. It has much to give when applied to other current social issues (mobility, financialization, etc.) and to theoretical improvement (that is, it can upgrade one's understanding of economic change by putting space and time at the centre of economic theories).
Stochastic domain decomposition for time dependent adaptive mesh generation

The efficient generation of meshes is an important component in the numerical solution of problems in physics and engineering. Of interest are situations where global mesh quality and a tight coupling to the solution of the physical partial differential equation (PDE) is important. We consider parabolic PDE mesh generation and present a method for the construction of adaptive meshes in two spatial dimensions using stochastic domain decomposition that is suitable for an implementation in a multi- or many-core environment. Methods for mesh generation on periodic domains are also provided. The mesh generator is coupled to a time dependent physical PDE and the system is evolved using an alternating solution procedure. The method uses the stochastic representation of the exact solution of a parabolic linear mesh generator to find the location of an adaptive mesh along the (artificial) subdomain interfaces. The deterministic evaluation of the mesh over each subdomain can then be obtained completely independently using the probabilistically computed solutions as boundary conditions. The parallel performance of this general stochastic domain decomposition approach has previously been shown. We demonstrate the approach numerically for the mesh generation context and compare the mesh obtained with the corresponding single domain mesh using a representative mesh quality measure.
Examining Slovenian trade flow sustainability

Glavni cilj ovog istraživanja je analizirati trgovinske tijekove roba i usluga Slovenije s ostatkom svijeta od pridruživanja Europskoj uniji (EU) u svibnju 2004. godine. Empirijsko istraživanje provedeno je primjenom Grangerovog testa uzročnosti i Vektorskog modela korekcije pogrešaka (VECM) koristeći tromjesečne podatke od 2005. do 2017. godine. Primijenjeni Hansen i Seo (2002) test potvrdio je pretpostavku linearnosti između promatranih varijabli i prikladnost empirijskog pristupa u radu. Rezultati istraživanja ukazuju na dominaciju uvoza nad izvozom u trgovinskom obrascu slovenskog gospodarstva i pozitivnu trgovinsku bilancu s ostatkom svijeta od vremena njenog pristupanja Europskoj uniji.
QUESTION 10 : BENEFIT-RISK ASSESSMENT IN ALL INDICATIONS AND POPULATIONS

• Depression is the most common psychiatric disorder. It is a chronic and recurrent disorder with a published lifetime prevalence of up to 17% [Kessler, 1994]. Depressive illness and anxiety disorders can result in significant impairment of daily functioning alongside significant morbidity and mortality. Despite the substantial economic and morbidity burden associated with depression, the disorder is often unrecognised and untreated.
Triphenylphosphonium Derivatives as Anti-tumour Prodrugs View project Biomedical imaging using microfluidics-based double emulsions as contrast agents View project

The emerging technique of photoacoustic imaging, especially in the near infra-red (NIR) window, permits high resolution, deep-penetration, clinically reliable sensing. However, few contrast agents are available that can specifically respond to intricate biological environments, and which are biodegradable and biocompatible. Herein, we introduce a new class of pH-sensitive organic photoacoustic contrast agent that operates in the second NIR window (NIR-II, 960–1,700 nm), which is derived from the self-assembled charge-transfer nanocomplex (CTN) by 3,3’,5,5’-tetramethylbenzidine (TMB) and its dication structure (TMB). The unique NIR-II-responsive CTN can specifically respond to pH change in the physiological range and allows noninvasive and sensitive visualization of the tumor acidic microenvironment (e.g. at pH 5) in mice with higher signal-to-noise ratio. The CTN is biodegradable under physiological conditions (e.g. pH 7.4), which alleviates the biosafety concern of nanoparticle accumulation in vivo. These results clearly show the potential of the TMB/TMB-based CTN as a promising pH-activated and biodegradable molecular probe for specific tumor photoacoustic imaging in the NIR-II region.
Shot Or Not: Comparison of NLP Approaches for Vaccination Behaviour Detection

Vaccination behaviour detection deals with predicting whether or not a person received/was about to receive a vaccine. We present our submission for vaccination behaviour detection shared task at the SMM4H workshop. Our findings are based on three prevalent text classification approaches: rule-based, statistical and deep learning-based. Our final submissions are: (1) an ensemble of statistical classifiers with task-specific features derived using lexicons, language processing tools and word embeddings; and, (2) a LSTM classifier with pre-trained language models.
Improving an SEU hard design using a pulsed laser

The purpose of this work is to present one investigation utilizing a pulsed laser as a tool to improve the Single Event Upset tolerance of a memory cell. These results coming with a previous ion testing evaluation of the circuit allow an optimization of the design. The laser results permit a more detailed analysis of the phenomenon leading to the upset and a precise localization of the most sensitive areas. As a result the behavior verification of the design combined with the use of robust elementary blocks strengthens the hardening capabilities of the cell.
An Experimental Study of Downstream Structures on the Flow-Induced Vibrations Energy Harvester Performances

This paper presents an experimental investigation for the characteristics of an energy harvesting device exploiting flowinduced vibration in a wind tunnel. A stationary bluff body is connected with a downstream tip body via an aluminium cantilever beam. Various lengths of aluminium cantilever beam and different shapes of downstream tip body are considered. The results show that the characteristics of the energy harvester’s vibration depend on both the length of the aluminium cantilever beam and the shape of the downstream tip body. The highest ratio between vibration amplitude and bluff body diameter was found to be 1.39 for an energy harvester with a symmetrical triangular tip body and L/D1 = 5 at 9.8 m/s of flow speed (Re = 20077). Using this configuration, the electrical energy was extracted with a polyvinylidene fluoride (PVDF) piezoelectric beam with different load resistances, of which the optimal value could be found on each Reynolds number. The highest power output was found to be 3.19 μW, at 9.8 m/s of flow speed (Re = 20077) and 27 MΩ of load resistance. Keywords—Downstream structures, energy harvesting, flowinduced vibration, piezoelectric material, wind tunnel.
Comparative Study of Diverse Face Recognition Approaches along with Intrinsic Worth and Recognition Rate

Face recognition is one of the research areas which have always attracted the attention of the researchers and research community. Because it is a varied application in automation, authentication, medical diagnosis, access control, surveillance and security applications. Face recognition is one of the most successful applications of image analysis and understanding. It has gained much attention in recent years. Various algorithms were proposed and their own have some limitations and merits for end-user application. The aim of this paper is to select an optimum technique of face feature selection. That can be used for multiple face object detection because feature representation and classification are two key steps for face recognition systems. Therefore, in this paper, a comparison of six effective feature computation methods is performed. In this comparison PCA, LDA, and ICA, SIFT, SURF, and ORB are considered. After comparison of these features, a promising feature extraction technique is selected for further application development.
Into ImgLib - Generic Image Processing in Java

The purpose of ImgLib, a Generic Java Image Processing Library, is to provide an abstract framework enabling Java developers to design and implement data processing algorithms without having to consider dimensionality, type of data (e. g. byte, float, complex float), or strategies for data access (e. g. linear arrays, cells, paged cells). This kind of programming has significant advantages over the classical way. An algorithm written once for a certain class of Type will potentially run on any compatible Type, even if it does not exist yet. Same applies for data access strategies and the number of dimensions. We achieve this abstraction by accessing data through Iterators and Type interfaces. Iterators guarantee efficient traversal through pixels depending on whether random coordinate access is required or just all pixels have to be visited once, whether real or integer coordinates are accessed, whether coordinates outside of image boundaries are accessed or not. Type interfaces define the supported operators on pixel values (like basic algebra) and hide the underlying basic type from algorithm implementation.
Configurable-ECC: Architecting a Flexible ECC Scheme to Support Different Sized Accesses in High Bandwidth Memory Systems

Designing error correction code (ECC) to guarantee strong reliability for high bandwidth memory (HBM) is imperative in high performance computers, especially for systems equipped with graphics processing units (GPUs). The design of ECC is challenging because future GPUs are expected to implement a memory subsystem supporting fine and coarse-grained data accesses to match the difference in the spatial locality of GPGPU applications. Current ECC designs, however, are developed for a fixed data fetch granularity. To have a more flexible design, we propose a novel memory protection scheme, called Config(urable)-ECC, which provides strong reliability for both fine and coarse-grained data accesses. Config-ECC consists of two tiers of ECC protection. The tier-1 code is a strong product code that can correct errors due to small granularity faults and detect errors caused by large granularity faults. The tier-2 code is an XOR-based code that is employed to correct errors incurred by large granularity faults. Config-ECC provides stronger reliability and/or lower energy consumption compared to state-of-the-art fixed 32B and 64B ECC schemes. It reduces the HBM energy by 17-21 percent while reducing the failure in time (FIT) rate by 20 times compared to a state-of-the-art fixed 64B ECC scheme with an insignificant 1.2 percent performance overhead.
Comparison Background Modeling Methods on Moving Object Detection in Video Sequences for Thailand

The research reported drivers in Thailand spent time on car an average of 61 hours stuck in traffic last year, followed by motorists in Colombia and Indonesia with an average 47 hours and the second in the world (behind Libya) for number of road accident deaths. Thus, manual traffic count is time consuming in order to identify which routes are used most, and to either improve or solve the problem that road or provide an alternative if there is an excessive amount of traffic with vehicle counting systems. For the first step of analysis the road accident in Thailand, real time segmentation algorithms of moving regions in image sequences is an important step in counting systems including automated video surveillance. Background subtraction of video sequences is mainly regards as a solved problem. In this paper not only helps better understand to which type of videos each method suits best for video surveillance of Thailand but also compared of basic background subtraction methods.
Global evaluation of gross primary productivity in the JULES land surface model v3.4.1

Abstract. This study evaluates the ability of the JULES land surface model (LSM) to simulate gross primary productivity (GPP) on regional and global scales for 2001–2010. Model simulations, performed at various spatial resolutions and driven with a variety of meteorological datasets (WFDEI-GPCC, WFDEI-CRU and PRINCETON), were compared to the MODIS GPP product, spatially gridded estimates of upscaled GPP from the FLUXNET network (FLUXNET-MTE) and the CARDAMOM terrestrial carbon cycle analysis. Firstly, when JULES was driven with the WFDEI-GPCC dataset (at 0. 5° × 0. 5° spatial resolution), the annual average global GPP simulated by JULES for 2001–2010 was higher than the observation-based estimates (MODIS and FLUXNET-MTE), by 25 and 8 %, respectively, and CARDAMOM estimates by 23 %. JULES was able to simulate the standard deviation of monthly GPP fluxes compared to CARDAMOM and the observation-based estimates on global scales. Secondly, GPP simulated by JULES for various biomes (forests, grasslands and shrubs) on global and regional scales were compared. Differences among JULES, MODIS, FLUXNET-MTE and CARDAMOM on global scales were due to differences in simulated GPP in the tropics. Thirdly, it was shown that spatial resolution (0. 5° × 0. 5°, 1° × 1° and 2° × 2°) had little impact on simulated GPP on these large scales, with global GPP ranging from 140 to 142 PgC year−1. Finally, the sensitivity of JULES to meteorological driving data, a major source of model uncertainty, was examined. Estimates of annual average global GPP were higher when JULES was driven with the PRINCETON meteorological dataset than when driven with the WFDEI-GPCC dataset by 3 PgC year−1. On regional scales, differences between the two were observed, with the WFDEI-GPCC-driven model simulations estimating higher GPP in the tropics (5° N–5° S) and the PRINCETON-driven model simulations estimating higher GPP in the extratropics (30–60° N).
Diet selection is related to breeding status in two frugivorous hornbill species of Central Africa

Abstract: Avian diet selection is hypothesized to be sensitive to seasonal changes in breeding status, but few tests exist for frugivorous tropical birds. Frugivorous birds provide an interesting test case because fruits are relatively deficient in minerals critical for reproduction. Here, we quantify annual patterns of fruit availability and diet for two frugivorous hornbill (Bucerotidae) species over a 5.5-y period to test for patterns of diet selection. Data from the lowland tropical rain forest of the Dja Reserve, Cameroon, are used to generate two nutritional indices. One index estimates the nutrient concentration of the diet chosen by Ceratogymna atrata and Bycanistes albotibialis on a monthly basis using 3165 feeding observations combined with fruit pulp sample data. The second index is an estimate of nutrient concentration of a non-selective or neutral diet across the study area based on tree fruiting phenology, vegetation survey and fruit-pulp sample data. Fifty-nine fruit pulp samples representing 40 species were analysed for 16 nutrient categories to contribute to both indices. Pulp samples accounted for approximately 75% of the observed diets. The results support expected patterns of nutrient selection. The two hornbill species selected a diet rich in calcium during the early breeding season (significantly so for B. albotibialis in July and August). Through the brooding and fledging periods, they switched from a calcium-rich diet to one rich in iron and caloric content as well as supplemental protein in the form of invertebrates. Calcium, the calcium to phosphorus ratio and fat concentration were the strongest predictors of breeding success (significant for calcium and Ca:P for B. albotibialis in June). We conclude that hornbills actively select fruit based on nutritional concentration and mineral concentration and that the indices developed here are useful for assessing frugivore diet over time.
Seismic Calibration of Group 1 IMS Stations in Eastern Asia for Improved IDC Event Location

Abstract : A Consortium of institutions which includes Maxwell Technologies, Inc., Massachusetts Institute of Technology's Earth Resources Laboratory (ERL), Weston Geophysical Corporation, the Russian Institute for Dynamics of the Geospheres (IDG), the Department of Geophysics of Peking University, and the Seismological Bureau of Sichuan Province has been assembled to conduct a research program directed toward the seismic travel time calibration of the 30 Group 1 IMS stations of eastern Asia. A carefully crafted scientific approach to this complex problem has been formulated in which rigorous seismological and statistical analyses of 3-D velocity models established for the regions surrounding the IMS stations of interest will be formally integrated with unique calibration data sets which will be provided by our international Consortium members to provide robust estimates of source-region specific station corrections (SSSCs), together with quantitative measures of the uncertainties in those estimates. A rationale for assigning priorities to the IMS stations to be investigated has been established, and a staged program of deliverables has been formulated in which preliminary calibration results for these priority stations will be provided six months after contract award and updated and refined on a regular basis throughout the three year performance period. We are currently assembling a preliminary 3-D velocity model of the entire region which is composed of a global background model on a 5 deg-by-5 deg grid (Stevens and McLaughlin, 1999), supplemented by more detailed models in regions where they are available.
Smoking as an early risk factor for problematic parenting practices

Abstract Parenting among those who use non-illicit and more common drugs such as cigarettes remains an understudied area for investigation. Secondary data analyses were performed in 2015 on a prospective study with parent and twin data available on n=3,009 individual members of female twin pairs born between July 1975 and June 1985 identified from Missouri-state birth records. Maternal smoking when the twins were 3+ years of age remained a significant predictor of offspring report of childhood sexual abuse (OR, 1.40; 95% CI, 1.02-1.92) after controlling for key covariates. Given limited public health resources, mothers who smoke during child’s preschool years may be targeted for tailored parenting intervention.
Conversion of an AFLP fragment into one dCAPS marker linked to powdery mildew resistance in melon 1

Resistance to powdery mildew races 1, 2 and 5 has been evaluated in F2/F3 families from a cross between the resistant line 'TGR-1551' and the susceptible Spanish cultivar 'Bola de oro'. Resistance is controlled by two independent genes, one dominant and one recessive, that both confer resistance to races 1, 2 and 5 of Podosphaera xanthii. Bulked segregant analysis (BSA) and amplified fragment length polymorphism (AFLP) technique have been used for the identification of markers linked to powdery mildew resistance. The AFLP marker E38M82 has been converted into a derived cleaved amplified polymorphic sequences (dCAPS) marker. The marker developed was codominant and the estimated distance with the dominant gene for powdery mildew resistance was 5.7 cM.
Hellenic Karst Aquifers Vulnerability Approach Using Factor Analysis: The Example of the Louros Karst Aquifers

The karst aquifers of the Hellenic territory display high vulnerability that is related to the existence of the epikarst zone. If present, the epikarst zone regulates the vertical movement of the groundwater, which results in the chemical pollutants staying longer within it, thus facilitating the inactivation of the microbial loads. The Hellenic karst is well developed; it displays high hydraulic conductivity, relatively large storage, and the characteristics of an important water reservoir. Although its porosity was calculated to be between 0.005–8%, the statistical processing of the springs’ discharge time series points to an increased storage. The increased storage was attributed to the presence of the epikarst zone, which regulates the water movement to the underlying formations, and finally to its discharge from the karst system through springs. In these areas, the influence of nitrogen compounds on the water quality is evident. The presence of cyanobacteria and toxic substances at concentrations that are too high for fresh, flowing waters whose temperature does not exceed 17 °C advocates the role of nutrients, even at concentrations that do not exceed the maximum permissible limits of drinking water. In mountainous areas, where agriculture is limited, the presence of these compounds is attributed to heavily polluting land uses. The impact of such uses became apparent from the application of factor analysis, which not only highlighted their contribution to the overall groundwater quality, but also determined their geographical distribution and origin. From the above, it becomes evident that there is a need for protection of the karst aquifers, and investigation of their vulnerability mechanisms. The Hellenic karst, which is expected to cover the drinking water needs in the near future, proves to be very vulnerable to any kind of pollution.