Miracle-dz/UniFAR-FTUs huggingface dataset:
Environmental drivers and trends in forage fish occupancy of the Northeast US shelf

1Biology Department, Woods Hole Oceanographic Institution, 266 Woods Hole Rd., Woods Hole, MA 02543, USA 2MIT/WHOI Joint Program in Oceanography/Applied Ocean Science and Engineering, Cambridge and Woods Hole, MA, USA 3Northeast Fisheries Science Center, National Marine Fisheries Service, 166 Water Street, Woods Hole, MA 02543, USA 4Northeast Fisheries Science Center, National Marine Fisheries Service, 28 Tarzwell Drive, Narragansett, RI 02882, USA ∗Corresponding author: tel/fax: +941-713-9883; e-mail: jsuca@ucsc.edu ‡Present address: Institute of Marine Science, University of California Santa Cruz, Santa Cruz, CA, United States and Environmental Research Division, NOAA Southwest Fisheries Science Center, Monterey, CA, USA
NDT_A_336947 163..172

Purpose: Suicide is an important health and social concern worldwide. Both suicidal ideation and suicide rates are higher in the elderly population than in other age groups; thus, more careful attention and targeted interventions are required. Therefore, we have developed a model to predict suicidal ideation in the community-dwelling elderly aged of >55 years. Patients and Methods: A random forest algorithm was applied to those who participated in the Korea Welfare Panel. We used a total of 26 variables as potential predictors. To resolve the imbalance in the dataset resulting from the low frequency of suicidal ideation, training was performed by applying the synthetic minority oversampling technique. The performance index was calculated by applying the predictive model to the test set, which was not included in the training process. Results: A total of 6410 elderly Korean aged of >55 (mean, 71.48; standard deviation, 9.56) years were included in the analysis, of which 2.7% had suicidal ideation. The results for predicting suicidal ideation using the 26 chosen variables showed an AUC of 0.879, accuracy of 0.871, sensitivity of 0.750, and specificity of 0.874. The most significant variable in the predictive model was the severity of depression, followed by life satisfaction and self-esteem factors. Basic demographic variables such as age and gender demonstrated a relatively small effect. Conclusion: Machine learning can be used to create algorithms for predicting suicidal ideation in community-dwelling elderly. However, there are limitations to predicting future suicidal ideation. A predictive model that includes both biological and cognitive indicators should be created in the future.
Nutritional Methodology Analysis of Factors Influencing the Comparison of Homocysteine Values between the Third National Health and Nutrition Examination Survey (NHANES) and NHANES 19991

Two important changes occurred in the time between the Third National Health and Nutrition Examination Survey (NHANES III) (1991–1994) and the later survey (NHANES 19991) regarding total homocysteine (tHcy), i.e., a change in matrix from serum to plasma and a change in analytical methods. The goals of this study were to determine the magnitude of potential differences between plasma and serum with regard to tHcy concentrations, and between the two analytical methods used in these surveys. Optimally prepared plasma, serum allowed to clot for 30 and 60 min at room temperature and serum allowed to clot for 30 and 60 min and subjected to four freeze-thaw cycles, prepared from blood samples collected from 30 healthy people, were analyzed by both methods. Serum samples had significantly higher tHcy concentrations than plasma samples, and the difference increased with longer clotting time. Freeze-thaw cycles had little or no effect on the variability or bias in the serum sample results. The tHcy results produced by the two analytical methods were significantly different, but consistent across sample types. On average, the results of the method used in NHANES III were lower by 0.64 mmol/L; however, the relative bias varied with tHcy concentration. The tHcy results determined in surplus serum from NHANES III overestimated tHcy concentrations by ;10% compared with optimally prepared plasma. The average method bias was 6% between the two analytical methods. On the basis of changes in matrix and methodology, direct comparison of tHcy results between the two surveys is inappropriate. J. Nutr. 130: 2850–2854, 2000.
Products of Dark CO2 Fixation in Pea Root Nodules Support Bacteroid Metabolism1

Products of the nodule cytosol in vivo dark [14C]C02 fixation were detected in the plant cytosol as well as in the bacteroids of pea (Pisum sativum L. cv "Bodil") nodules. The distribution of the metabolites of the dark CO2 fixation products was compared in effective (fix+) nodules infected by a wild-type Rhizobium leguminosarum (MNF 300), and ineffective (fix-) nodules of the R. Ieguminosarum mutant MNF 3080. The latter has a defect in the dicarboxylic acid transport system of the bacterial membrane. The 14C incorporation from ['4C]CO2 was about threefold greater in the wild-type nodules than in the mutant nodules. Similarly, in wild-type nodules the in vitro phosphoenolpyruvate carboxylase activity was substantially greater than that of the mutant. Almost 90% of the 14C label in the cytosol was found in organic acids in both symbioses. Malate comprised about half of the total cytosol organic acid content on a molar basis, and more than 70% of the cytosol radioactivity in the organic acid fraction was detected in malate in both symbioses. Most of the remaining 14C was contained in the amino acid fraction of the cytosol in both symbioses. More than 70% of the 14C label found in the amino acids of the cytosol was incorporated in aspartate, which on a molar basis comprised only about 1% of the total amino acid pool in the cytosol. The extensive 14C labeling of malate and aspartate from nodule dark (14CJCO2 fixation is consistent with the role of phosphoenolpyruvate carboxiase in nodule dark CO2 fixation. Bacteroids from the effective wild-type symbiosis accumulated sevenfold more 14C than did the dicarboxylic acid transport defective bacteroids. The bacteroids of the effective MNF 300 symbiosis contained the largest proportion of the incorporated 14C in the organic acids, whereas ineffective MNF 3080 bacteroids mainly contained 14C in the amino acid fraction. In both symbioses a larger proportion of the bacteroid 14C label was detected in malate and aspartate than their corresponding proportions of the organic acids and amino acids on a molar basis. The proportion of 14C label in succinate, 2-oxogultarate, citrate, and fumarate in the bacteroids of the wild type greatly exceeded that of the dicarboxylate uptake mutant. The results indicate a central role for nodule cytosol dark CO2 fixation in the supply of the bacteroids with
Involvement of rho p 21 in the GTP-enhanced Calcium Ion Sensitivity of Smooth Muscle Contraction *

In the rabbit mesenteric arterial smooth muscle skinned by saponin, Caa+ induced contraction in a concentration-dependent manner. Guanosine 5’-(3-0thio)triphosphate (GTPyS), a non-hydrolyzable GTP analogue, lowered the Ca2+ concentrations required for this contraction and increased the Ca” sensitivity of the skinned smooth muscle contraction. GTPyS alone did not induce the contraction in the absenoe of Ca”. This GTPyS-enhanced Ca2+ sensitivity was completely abolished by an exoenzyme of Staphylococcus aureu8, named EDIN, and an exoenzyme of Clostridium botulinum, named C3, both of which are known to ADPribosylate the rho p21 family that belongs to the rm p21-like small GTP-binding protein superfamily. The GTPyS-bound form of rhoA p21 overcame the inhibitory action of EDIN. smg p21B, another small GTPbinding protein, was inactive. EDIN ADP-ribosylated a protein, which was most likely to be rho p21, in the skinned smooth muscle. The GTPyS-bound form of rhoA p21, but not the GDP-bound form, substituted for GTPyS and enhanced the Ca” sensitivity of the skinned smooth muscle contraction. smg p21B was inactive. These results indicate that rhoA p21 is involved in the GTPyS-enhanced Caa+ sensitivity of the smooth muscle contraction.
A Framework for Evaluating 5G Infrastructure Sharing with a Neutral Host

—Infrastructure sharing has been a growing topic of interest in the context of the ﬁfth generation of cellular technology (5G). With the expected Ultra-Dense Networks (UDN), which will lead to a relevant increase in the number of sites, concerns regarding the availability of space for new towers and masts in city centers arise. Also, the capacity of mobile network operators to handle the costs of these networks by themselves assuring the return of investment is put to the test. Neutral hosts appear as a promising solution to this challenge; however, it can be a complex business model. This paper proposes a mathematical model for calculating the beneﬁts of infrastructure sharing, including the scenario with a neutral host, aiming at applying it to a tool-based framework which compares it to other sharing strategies, suggesting the best alternative from the ﬁnancial perspective. Preliminary results show that sharing with a neutral host can increase savings in comparison to other passive sharing strategies; however, this advantage seems to hold only for a certain range of market share of the involved operators, being also affected by the amount of overlap of the desired infrastructures.
Patient Selection for Operable Pancreatic Cancer

Stephan B. Dreyer, MD, y Mark Pinese, PhD,z Nigel B. Jamieson, MD, PhD, y§ Christopher J. Scarlett, PhD, Emily K. Colvin, PhD,z Marina Pajic, PhD,z Amber L. Johns, BMedSc,z Jeremy L. Humphris, MD, PhD,z Jianmin Wu, PhD,z Mark J. Cowley, PhD,z Angela Chou, MD, PhD,zjj Adnan M. Nagrial, MD,z Lorraine Chantrill, MD, PhD,z Venessa T. Chin, MD, PhD,z Marc D. Jones, MPhil, Kim Moran-Jones, PhD,yy, Australian Pancreatic Cancer Genome Initiative,z, Glasgow Precision Oncology Laboratory, , Christopher Ross Carter, MD,y Euan J. Dickson, MD,y Jaswinder S. Samra, MD, DPhil,zz§§ Neil D. Merrett, MD, jjjj Anthony J. Gill, MD, PhD,z yyy James G. Kench, MD,zzzz Fraser Duthie, MD, §§§ David K. Miller, BASc, Susanna Cooke, PhD, Daniela Aust, MD, PhD,jjjjjj Thomas Knösel, MD, Petra Rümmele, MD,yyyy Robert Grützmann, MD, PhD,zzzz Christian Pilarsky, MD, PhD,zzzz Nam Q. Nguyen, MD,§§§§ Elizabeth A. Musgrove, PhD, Peter J. Bailey, PhD, Colin J. McKay, MD, y Andrew V. Biankin, MD, PhD, y and David K. Chang, MD, PhD y
1 Formulation , in vitro and in silico characterization of 2 “ nano-in-micro ” dry powder inhalers containing 3 meloxicam 4

13 Pulmonary delivery has high bioavailability, a large surface area for absorption and limited 14 drug degradation. Particle engineering is important to develop inhalable formulations to improve 15 the therapeutic effect. In our work, the poorly water-soluble meloxicam (MX) was used as an 16 active ingredient, which could be useful for the treatment of non-small cell lung cancer, cystic 17 fibrosis and chronic obstructive pulmonary disease. We aimed to produce inhalable 18 “nano-in-micro” dry powder inhalers (DPI) containing MX and additives (poly-vinyl-alcohol, 19 leucine). We targeted the respiratory zone with the microcomposites and reached a higher drug 20 concentration with the nanonized active ingredient. We did the following investigations: particle 21 size analysis, morphology, density, interparticular interactions, crystallinity, in vitro dissolution, in 22 vitro permeability, in vitro aerodynamics (Andersen Cascade Impactor), in silico aerodynamics 23 (stochastic lung model). We worked out a preparation method, by combining wet milling and 24 spray-drying. We produced spherical, 3-4 μm-sized particles built up by MX nanoparticles. The 25 increased surface area and amorphization improved the dissolution and diffusion of the MX. The 26 formulations showed appropriate aerodynamical properties: 1.5-2.4 μm MMAD, 72-76% FPF 27 values. The in silico measurements proved the deposition in the deeper airways. The samples were 28 suitable for the treatment of local lung diseases. 29
acute renal failure forum Acute renal failure . I . Relative importance of proximal vs . distal tubular injury *

Bonventre, J. V. , M. Brezis, N. Siegel, S. Rosen, D. Portilla, and M. Venkatachalam. Acute renal failure. I. Relative importance of proximal vs. distal tubular injury. In: Acute renal failure forum, edited by W. Lieberthal and S. K. Nigam. Am. J. Physiol. 275 (Renal Physiol. 44): F623–F632, 1998. —For more than 15 years, there has been an ongoing debate regarding the nephron segment(s) most severely injured in acute renal failure (ARF) induced by an ischemic or toxic insult. Although some investigators have argued that the proximal tubule (and particularly the S3 segment) is the major target of injury in ARF, others have held the view that damage to the distal nephron [particularly the medullary thick ascending limb (MTAL) segment] plays a more important role in this disease. In this discussion, the first of three on different aspects of ARF that have been hotly debated, we have invited several experts to discuss their opinions on this issue. The goals of this first discussion (and the subsequent two articles in this forum) are to establish areas of consensus in each area of controversy and also to identify unanswered questions that represent important areas for future research.
Effect of Preventing Hypertension

In the previous paper we showed that baroreceptor resetting in spontaneously hypertensive rats (SHR) resulted from an incomplete matching of increased receptor strain sensitivity with reduced vessel wall distensibility. Here SHR and Wistar-Kyoto controls were treated with antihypertensive drugs in their drinking water (reserpine, hydrochlorothiazide, and hydralazine) from 5 weeks of age so that we might examine the role of blood pressure in the SHR vessel wall-receptor mismatch. Radius and receptor properties were measured using the in vitro aortic arch-aortic nerve preparation at 8, 14, 20, and 30 weeks. We found that baroreceptors from SHR with normal blood pressures had normal pressure thresholds and suprathreshold pressure sensitivities. However, the treated SHR receptors still had lower strain thresholds and the aortas still were less distensible than were the normal. Now, however, the increased receptor sensitivity was sufficient to normalize the relationship between baroreceptor function and arterial blood pressure. We conclude that, although blood pressure may be restored to normotensive levels by therapy, vascular abnormalities may continue to develop. CircRes 47: 829-834, 1980
Data-driven Vocal Pitch Extraction for Indian Art Music Melodic Analysis

CATALÀ – L’exploració melòdica de la música clàssica de la Índia és un tema emergent en el camp del Music Information Retrieval (MIR), ja que inclou diverses tasques que contribueixen en un millor coneixement d’aquesta cultura musical. Les anotacions contrastades de melodia de veu són unes dades essencials per solucionar aquesta tasca, però l’extracció automàtica d’aquestes de senyals d’àudio polifònics no està resolta a dia d’avui. Actualment, l’estat de l’art en aquest tema proposa models d’aprenentatge automàtic no supervisat que tenen un rendiment considerablement alt. Tot i així, aquests models estan exlusivament dissenyats utilitzant dades de música occidental (pop, rock, blues i els estils relacionats) i per tant, el rendiment d’aquests algoritmes aplicats a música Índia baixa notablement. A més, donada l’escassetat de dades ben anotades de música de la Índia per aquesta tasca, no hi ha propostes en la literatura que dissenyin algoritmes d’aprenentatge automàtic que funcionin especialment per a aquest tradició. En aquest treball, volem atacar aquest problema proposant dos contribucions principals: (1) La creació d’un dataset que inclogui dades de melodia vocal per a la música Índia, (2) L’entrenament i evaluació amb les nostres dades d’un mètode de l’estat de l’art per la tasca que estem atacant, per tal de que tingui bons resultats per a la música Índia. Adicionalment, en aquest treball estudiem la literatura relacionada amb el nostre problema per assentar les bases de la nostra recerca, centrant-nos en l’exploració melòdica de la música tradicional índia i l’extració automàtica de la melodia de un senyal d’àudio. Dins el marc d’aquesta tesi també contribuïm a la llibreria de Python mirdata, integranr diversos datasets de música índia i altres cultures no-occidentals. La idea principal és contribuïr en la recerca d’aquestes tradicions musicals. Esperem que els resultats d’aquesta tesi contribueixin a una millor exploració melòdica de la música clàssica de la Índia i ajudin a superar les barreres produïdes per l’escassetat de dades i metodologies per l’extració de melodia per aquesta cultura tant extensa i rellevant.
Hydrodynamic Stability

sources, they provide a coherent exposition of the subjects treated together with sufficient information about the referenced papers so that one can decide whether or not he or she needs or wishes to consult them for further details. I do not see this as a textbook for even an advanced class, but it (or parts of it) could be used as a skeleton to be fleshed out by independent reading or supplementary lecturing. To say that such an extensive work shows signs of hasty writing would be manifestly unfair. Still, it would have benefitted by some editorial attention, for it seems to me that it contains more misspelled and misused words and more awkward or obscure sentences than is normal. However, none of this really detracts from its usefulness. The typography also deserves comment. It is customary in mathematical text to set variables in italic type and operators in roman. Here everything is in roman. Although I was aware of this while reading, I did not find it any way confusing. If substantial costs in typesetting are thus effected, perhaps it should be used more widely, although I prefer the usual convention. Although it might appear appropriate to compare the book under review with a similar one Vagues el Ouvrages Petroliers en Mer, by G. Susbielles and Chr. Bratu, Editions Technip, Paris, 1981), which appeared almost simultaneously, I think I should disqualify myself on the grounds of possible partiality. We are fortunate, however, to have two such treatises available.
Electric Vehicle Route Assistance Using Forecast on Charging Station

—This paper presents a method to provide route assistance for electric vehicles by forecasting availability of charging spots in a charging station. The method uses location and reachability information of other electric vehicles along the route in order to estimate charging spot occupancy ratio at the charging station. By using such information, a risk factor for charging at a station along a planned route of an electric vehicle is calculated. The risk factor is continuously monitored, and when risk becomes high, a new route based on other charging stations located along the route is proposed to the driver. By dynamically monitoring travel routes based on charging station capacity and population of electric vehicles around the charging station, a prediction can be made about the availability of charging stations. Thus, in order to have faster travel times, electric vehicle drivers can be opportunistically advised to take appropriate routes with less crowded charging stations.
DMD052597 1867..1874

The primary objective of this study was to determine the in vivo absorption properties of valacyclovir, including the potential for saturable proton-coupled oligopeptide transporter 1 (PepT1)-mediated intestinal uptake, after escalating oral doses of prodrug within the clinical dose range. A secondary aim was to characterize the role of PepT1 on the tissue distribution of its active metabolite, acyclovir. [H]Valacyclovir was administered to wild-type (WT) and PepT1 knockout (KO) mice by oral gavage at doses of 10, 25, 50, and 100 nmol/g. Serial blood samples were collected over 180 minutes, and tissue distribution studies were performed 20 minutes after a 25-nmol/ g oral dose of valacyclovir. We found that the Cmax and area under the curve (AUC)0–180 of acyclovir were 4to 6-fold and 2to 3-fold lower, respectively, in KOmice for all four oral doses of valacyclovir. The time to peak concentration of acyclovir was 3to 10-fold longer in KO compared with WT mice. There was dose proportionality in the Cmax and AUC0–180 of acyclovir in WT and KOmice over the valacyclovir oral dose range of 10–100 nmol/g (i.e., linear absorption kinetics). No differences were observed in the peripheral tissue distribution of acyclovir once these tissues were adjusted for differences in perfusing drug concentrations in the systemic circulation. In contrast, some differences were observed between genotypes in the concentrations of acyclovir in the distal intestine. Collectively, the findings demonstrate a critical role of intestinal PepT1 in improving the rate and extent of oral absorption for valacyclovir. Moreover, this study provides definitive evidence for the rational development of a PepT1-targeted
Pattern Based Evaluation of Blockchain Technology as a Catalyst for Business Model Innovation: Exploratory Research with Focus on the Potential Implications for e-Health

As blockchain technology became more established in the financial arena, federal health IT officials, vendors and developers started looking at its potential and its use in the healthcare sector. Lately, there has been a major hype around the potential of the technology. It is described as a disruptive technology that could enable business model innovation with increased transparency, new models of partnerships and possible disintermediation. Business modelling was recognized as a potential tool to help the healthcare sector to determine a technology implementation strategy by involving all the important stakeholders in a value-driven dialogue about the way in which the technology should be utilized. This research focused on exploring the potential of the blockchain technology for business model innovation with the use of business model patterns as a theoretical construct. From the scientific perspective, research contributed to a better understanding of the role of business model patterns as a construct with multipurpose character. The construct was used in a role of classification device to gain an understanding over the technology associated business model logics and in a role of instruments of scientific inquiry to explore potential technology implications. A two-way relationship between the disruptive technology and business models was considered. As a result, tokenization was proposed as a new business model pattern, specific to the blockchain technology. Moreover, value patterns (patient empowerment, privacy by design, security by design, transparency by design) were recognized as an important matter that is potentially impacting future business models. In the second step, business model patterns were evaluated in the context of e-Health industry specific moderators. A Discussion with the implication of the technology from the business model innovation perspective was provided.
A Novel Scheme for Online Bangla Handwriting Recognition

– Online handwriting recognition is very challenging for Indic scripts because of its huge no of shapes in total character set (isolated, modified and compound). To handle such situation we plan to use strokes for recognition rather than character. This paper describes a procedure to recognize online Bangla handwriting recognition in unconstrained domain based on strokes. For simplicity of recognition he strokes divided into five different categories in the first phase and in second phase detailed classification is done. Next based on the recognized stroke we plan to recognize the characters/words. We have obtained encouraging results in the experiment.