Miracle-dz/UniFAR-FTUs huggingface dataset:
CCID_A_206115 489..495

Betty Ekawati Suryaningsih Ahmad Hamim Sadewa Yohanes Widodo Wirohadidjojo Hardyanto Soebono 1Department of Dermatovenereology, Faculty of Medicine Islamic Indonesia University, Yogyakarta, Indonesia; 2Department of Dermatovenereology, Faculty of Medicine Universitas Gadjah Mada, Yogyakarta, Indonesia; 3Department of Biochemistry, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia Introduction: Melasma is an acquired hypermelanosis of the face. The pathogenesis of melasma is multifactorial and may be caused by interactions between genetics and the environment. Research has shown that skin pigmentation is regulated by the Melanocortin1 Receptor gene (MC1R). In Japanese populations, Val92Met and Arg163Gln genotypes of MC1R gene polymorphisms are associated with freckles and lentigo solaris, because they have skin types II–III, but for Indonesians who are skin type IV, hyperpigmentation disorders are often melasma. Purpose: This study aimed to identify the association between Val92Met and Arg163Gln genotypes of MC1R gene polymorphisms with the incidence of melasma in a Javanese women population. Patients and methods: This study used unmatched case-control design, conducted by clinical examination and questionnaire. Data were analyzed with Chi-squared test and Odds Ratio (OR). Results: This study evaluated 158 Javanese women from 18–60 years old with 79 case and 79 control subjects. The genotype of Val92Met was found more common in melasma subjects than in non-melasma (p=0.005) with (OR2.53; 95% CI:1.21–5.29). By using a bivariate test we showed sun exposure and family history of melasma were risk factors for melasma (OR:1.99; 95% CI:1.04–3.78) and (OR:35.32; 95% CI:10.25–121.70). However, genotype of Arg163Gln was not a risk factor for the incidence of melasma (OR: 0.86; 95% CI:0.39–1.89). Conclusion: The findings showed Val92Met genotypes, sun exposure and family history were risk factors for melasma incidence. This is the first study on incidence of melasma in an Indonesian population and contributes to ongoing efforts to understand the mechanisms of melasma.
The Global Economic Crisis and China’s Development and Trade: Evidence-based Policy Responses and Choices

Regional and global economic crises deeply affect all economies worldwide but especially developing Asia where trade and FDI have been crucial ingredients of growth and poverty reduction (World Bank, 2009). The paper introduces a new endogenous trade-growth model embracing crises with improved structural and modelling features over existing approaches (such as descriptive analysis. panel regression and CGE/GTAP, see Tran Van Hoa, 2004) to provide more credible outcomes in the sense of Friedman (1953)-Kydland data-model realism or consistency (2006) to study the impact of these crises on China. Appropriate policy responses and choices are then recommended for informed debates by researchers and for possible use as important inputs by policy-makers.
Effect of Plant Biostimulants on Fruit Set, Yield, and Quality Attributes of “Farbaly” Apricot Cultivar

Apulia region (southern Italy) is excellent for heavy production of apricot (Prunus armeniaca L.). Fruit quality is a combination of physical, chemical and nutritional characteristics. The present experiment was laid in the commercial orchard in Cerignola (Foggia district, Apulia region, 41°15’49’’N; 15°53’59’’E; 126 a.s.l.) during the 2014-2015 season. The experiment consisted of the use of three biostimulant treatments (Hendophyt®, Ergostim® and Radicon®) compared with untreated control on ‘Farbaly’ apricot cultivar, in order to evaluate the vegeto-productive and fruit qualitative attributes. Foliar spray of biostimulants was applied at different times during the growth season (at red ball, fruit setting and fruit development stages). Experimental data showed some specific differences among the biostimulant treatments, which fruit set, growth and productivity were affected. Moderate influences were found regarding the qualitative attributes of fruits. The soluble solid content was positively affected by Hendophyt® treatment. Antioxidant capacity was significantly higher in Hendophyt® and Radicon® treatments respect to the untreated control. Keywords—Prunus Armeniaca L. , biostimulants, fruit set, fruit quality.
Oncogenes Abl Cellular Transformation by eIF 4 B Phosphorylation by Pim Kinases Plays a Critical Role in

Alterations in translation occur in cancer cells, but the precise pathogenic processes and mechanistic underpinnings are not well understood. In this study, we report that interactions between Pim family kinases and the translation initiation factor eIF4B are critical for Abl oncogenicity. Pim kinases, Pim-1 and Pim-2, both directly phosphorylated eIF4B on Ser406 and Ser422. Phosphorylation of eIF4B on Ser422 was highly sensitive to pharmacologic or RNA interference-mediated inhibition of Pimkinases. Expression andphosphorylation of eIF4B relied upon Abl kinase activity in both v-Abland Bcr-Abl–expressing leukemic cells based on their blockade by theAbl kinase inhibitor imatinib. Ectopic expression of phosphomimeticmutants of eIF4B conferred resistance to apoptosis by the Pim kinase inhibitor SMI-4a in Abl-transformed cells. In contrast, silencing eIF4B sensitized Abltransformed cells to imatinib-induced apoptosis and also inhibited their growth as engrafted tumors in nude mice. Extending these observations, we found that primary bone marrow cells derived from eIF4B-knockdown transgenicmice were less susceptible to Abl transformation, relative to cells fromwild-typemice. Taken together, our results identify eIF4B as a critical substrate of Pim kinases in mediating the activity of Abl oncogenes, and they highlight eIF4B as a candidate therapeutic target for treatment of Abl-induced cancers. Cancer Res; 73(15); 4898–908. 2013 AACR.
Time Partitioning Favors the Coexistence of Sympatric Crab-Eating Foxes (Cerdocyon thous) and Pampas Foxes (Lycalopex gymnocercus)

Abstract Crab-eating foxes (Cerdocyon thous) and pampas foxes (Lycalopex gymnocercus) are very similar in body size and food habits, with distributional ranges that overlap extensively in South America. We used camera-trap records of both species obtained at the Iberá Nature Reserve (INR), northeastern Argentina, to test the hypothesis that, when living in sympatry, they reduce competition by using different habitats and by being active at different times. Camera-trap records obtained at 2 additional sites inhabited by only 1 of these species, the Atlantic Forest of Misiones (AF) and Lihué Calel National Park (LCNP), were used to determine the activity patterns of these foxes when living alone. At INR, we set 41 camera-trap stations in 2 habitats (shrubland forest and flooded grassland), and in 2 treatments per habitat (with or without cattle). Three stations also were set in gallery forests. We obtained 540 photographs of crab-eating foxes (289 records) and 175 photographs of pampas foxes (115 records) in 1,521 camera-trap days. At LCNP, 27 camera-trap stations (1,002 camera-trap days) provided 109 records of pampas foxes. At AF, 195 camera-trap stations (11,689 camera-trap days) provided 103 records of crab-eating foxes. At INR, crab-eating foxes were more frequently recorded in forest habitats, whereas pampas foxes preferred opened grasslands. However, both species were found in all habitats and their recording rates were not negatively correlated. At INR, crab-eating foxes were nocturnal, with peaks of activity after dusk and before dawn, a pattern similar to that observed at AF and elsewhere. At INR, pampas foxes showed a peak of activity between 0000 and 0400 h and another between 1000 and 1300 h, a pattern that differed from that observed at LCNP and other places, where the species is mostly nocturnal. At INR, pampas foxes reduced their activity at times when activity of presumably dominant crab-eating foxes was high, which may facilitate their coexistence.
Wi-Fi 6 performance measurements of 1024-QAM and DL OFDMA

IEEE 802.11ax is the new standard introduced by the IEEE that focuses on improving efficiency of Wireless LANs. Among others, two of the newly introduced features are 1024 Quadrature Amplitude Modulation (QAM) and Orthogonal Frequency Division Multiple Access (OFDMA). In this paper, the expected throughput gain of 25% with the new 1024-QAM and expected latency reduction with downlink (DL) OFDMA are examined with state of the art reference boards of two different Wi-Fi chipset manufacturers. Using three Samsung S10 mobile phones as clients, experiments were performed to measure the expected increase in throughput and decrease in latency.The 25% increase in throughput with 1024-QAM was achieved, albeit with a maximum range of operation of less than 6 meters when using a maximal transmit power for MCS 11. We observed a very low percentage of packets transmitted using DL OFDMA in the traffic profiles used. We conclude that the introduction of DL OFDMA does not have a significant impact on the latency with the test scenarios covered. The performance of DL OFDMA is heavily dependent on the ability of the access point to properly schedule DL OFDMA transmissions. The number of clients, packet size, and buffer size play an essential role in the scheduling process. Based on our measurements the benefit of DL OFDMA is expected to be limited unless the number of clients is substantially higher than the three clients used, as would be the case in a stadium, train, or mall.
LINK PERFORMANCE ABSTRACTION FOR ML RECEIVERS BASED ON RBIRMETRICS BACKGROUND OF THE INVENTION

(54) LINK PERFORMANCE ABSTRACTION FOR (56) References Cited ML RECEIVERS BASED ON RBIRMETRICS U.S. PATENT DOCUMENTS (75) Inventors: Hongming Zheng, Beijing (CN); Wu 7,065,136 B1* 6, 2006 Porter et all 375,232 May, Shanghai (CN), Yangseok Choi, 2002/0099985 A1* 7/2002 Cheng . T14,704 Portland, OR (US); Senjie Zhang, 2006/0
What determines customers’ engagement in the digital service process?

Purpose The purpose of this paper is to examine customer engagement behavior (CEB) in digital environments. Specifically, the paper seeks to determine the factors that affect CEB in the different parts of the digital service process. Design/methodology/approach A longitudinal, qualitative, single-case study is used to examine CEB in digital environments. The selected case company is a provider of streaming TV services. Both primary data, gathered from interviews, focus groups and participant observations in meetings with a selected focus group, and secondary data, gathered from company websites sources, were used. Findings This study shows that CEB is determined by different factors in different phases of the digital service process. Moreover, the results show that engagement is highlighted during the front-end phase of the process. During the back-end phase, the role of engagement is realized by maintaining and updating solutions. Originality/value The originality of the research is based on the study of CEB in the context of the digital service process. The factors that affect CEB are classified as customer-based, firm-based and context-based factors.
Interdependencies between Elements of Governance and Auditing: Evidence from Germany

This study is the first to examine empirically the relation between audit fees, client and governance attributes in Germany. Auditing is an essential element in the system of corporate governance. Further elements include internal control institutions and management compensation. All these elements of corporate governance are designed to reduce agency problems and information asymmetries. Therefore, interdependencies between these instruments are likely to exist. This study differs from existing research on the association between audit fees and governance institutions as it explicitly considers the German governance regime with its two-tier board system. Using data from German stock market companies, we examine whether governance elements complement or substitute the monitoring role of auditing. After adjustments for size effects, the regression results suggest that the ratio of bonus to total payments as well as the existence of an audit committee significantly lower audit fees.
Comparative efficacy of plant extracts in managing whitefly (bemisia tabaci gen) and leaf curl disease in okra (abelmoschus esculentus l)

Okra leaf curl disease (OLCD) is an important disease responsible for yield losses in okra in all okra growing regions in the world. Effective management of the OLCD is very important in order to improve yield. The study was conducted to evaluate the effectiveness of different botanicals in the management of the OLCD. The treatments applied were 10% (w/v) crude extract each of neem leaf, garlic, mahogany bark, chili pepper fruit, pawpaw dried leaf, bougainvillea leaf and the control (water), in a randomised complete block design with four replications. The plant extracts significantly reduced the population of whitefly vector, as well as the incidences and severities of OLCD infections and increased fruit yield compared to the control (P 0.05). Fruit yield was also negatively correlated with the severity of OLCD (r = -0.857; P< 0.05) and whitefly population (r = -0.750; P< 0.05). Farmers can manage OLCD in their okra fields by spraying with neem leaf or garlic extracts in order to improve fruit yields.
Periprocedural Myocardial Infarction During Native Coronary Artery Percutaneous Intracoronary and Noninvasive Imaging for Prediction of Distal Embolization and

Vishal G. Patel, Kimberly M. Brayton, Gary S. Mintz, Akiko Maehara, Subhash Banerjee and Intervention Periprocedural Myocardial Infarction During Native Coronary Artery Percutaneous Intracoronary and Noninvasive Imaging for Prediction of Distal Embolization and Print ISSN: 1941-9651. Online ISSN: 1942-0080 Copyright © 2013 American Heart Association, Inc. All rights reserved. Dallas, TX 75231 is published by the American Heart Association, 7272 Greenville Avenue, Circulation: Cardiovascular Imaging doi: 10.1161/CIRCIMAGING.113. 000448 2013;6:1102-1114 Circ Cardiovasc Imaging. http://circimaging.ahajournals. org/content/6/6/1102 World Wide Web at: The online version of this article, along with updated information and services, is located on the
A Duration-Dependent Regime Switching Model for an Open Emerging Economy

We employ duration-dependent Markov-switching vector auto-regression (DDMSVAR) methodology to construct an economic cycle model for an emerging economy. By modifying the software codes for DDMSVAR methodology written by Pelagatti (2003), we show how to estimate the economic cycles in an emerging economy where macroeconomic shocks are suddenly observed and their levels are deep. The monthly values of net international reserves, domestic debt, inflation and industrial production in the Turkish economy from January 1989 to July 2007 are used for constructing the empirical analysis. Empirical evidence shows that DDMSVAR model can be successfully used in an emerging economy to estimate the cycles using basic macroeconomic indicators.
The police officers' perception of the adequacy of surveillance training; a case study of police trainers and -field intelligence officers

The current rise in criminal activities, posses a need for the police officers to be equipped with surveillance techniques . Surveillance training is therefore necessary for combating crime in Kenya and anywhere in the world. The study therefore sought to document empirical evidence on challenges facing surveillance at CID training school. This study therefore generated abase line data that can be used to determine the inadequacies of the training for intelligence officers. It I also sought to identify ways o f improving the training syllabus, and document the challenges encountered by field intelligence officers in their work. The study was carried out at CID Training School and CID headquarters, both of which were purposively selected. The target population of the study comprised of 100 intelligence officers from the Criminal Intelligence Unit which require surveillance technique and 18 CID trainers who were randomly selected from a total population of. Data was collected using questionnaires and a key informant guide. Descriptive statistics namely frequency counts and percentages were generated and analyzed using the statistical package for social sciences (SPSS). The study found out that CID trdfnirjg was inadequate due to insufficient basic resources such as Video recorders, cameras, tape recorders, binoculars, projectors, unqualified instructors, training facilities and time allocation to the subject. It was also established that there’s, slow feedback from the senior commanders on recommendations for action by the field intelligence officers. The study further found out that there is under funding by the government to facilitate the training.
Graph-based representations and techniques for image processing and image analysis

In this paper we will discuss the use of some graph-based representations and techniques for image processing and analysis. Instead of making an extensive review of the graph techniques in this 6eld, we will explain how we are using these techniques in an active vision system for an autonomous mobile robot developed in the Institut de Rob otica i Inform atica Industrial within the project “Active Vision System with Automatic Learning Capacity for Industrial Applications (CICYT TAP98-0473)”. Speci6cally we will discuss the use of graph-based representations and techniques for image segmentation, image perceptual grouping and object recognition. We 6rst present a generalisation of a graph partitioning greedy algorithm for colour image segmentation. Next we describe a novel fusion of colour-based segmentation and depth from stereo that yields a graph representing every object in the scene. Finally we describe a new representation of a set of attributed graphs (AGs), denominated function-described graphs (FDGs), a distance measure for matching AGs with FDGs and some applications for robot vision. 2001 Pattern Recognition Society. Published by Elsevier Science Ltd. All rights reserved.
Invariance in Human Visual Perception

This dissertation explores invariance in human visual perception via three unique studies. In the first two studies we probe the visual system to see how robust it is to impoverished stimuli. These investigations not only offer limits on perceptual abilities, but also offer key insights into the mechanisms underlying vision.The first study explores rapid category detection, as discovered by Thorpe, Fize, and Marlot (1996). This study demonstrated that the human visual system can detect object categories in natural images in as little as 150 ms. To gain insight into this phenomenon and to determine its relevance to naturally occurring conditions, we degrade the stimulus set along a wide variety of image dimensions and investigate the effects on perception. We discover that rapid category detection in humans is quite robust to naturally occurring degradations and is mediated by a non-linear interaction of visual features.This investigation into degradation is followed by our second study where we explore the limits of 3D shape perception. The shape-from-texture and shape-from-shading perspectives would motivate that 3-D perception vanishes once low-level cues are disrupted. Is this the case in human vision? Or can top-down influences salvage the percept? In this study, we explore this question by employing a gauge-figure paradigm similar to that used by Koenderink et al (1992). Subjects were presented degraded natural images and instructed to make local assessments of slant and tilt at various locations thereby quantifying their internal 3-D percept. Analysis of subjects' responses reveals recognition to be a significant influence thereby allowing subjects to perceive 3-D shape at high levels of degradation. Specifically, we identify the medium-blur condition, images approximately 32 pixels on a side, to be the limit for accurate 3-D shape perception. In addition, we find that degradation affects the perceived slant of point-estimates making images look flatter as degradation increases.These 2 studies, in conjunction with previous work, point to 32-pixel color images as a rough threshold for a rich perceptual experience. The first study demonstrates that rapid recognition breaks down at around this point, and the second shows that it is also the limit to reliably perceive 3-D shape. Presumably many perceptual abilities are tied together at this level - shape, recognition, etc, so that when one percept is lost, other percepts break as well.In the third study, we explore how invariant properties of the natural world drive perceptual coding mechanisms in the brain. Specifically, we explore how the statistics of object regions in natural images motivate a sensitivity to hue by the perceptual system. To investigate this question, we compute the coding advantage of using hue angle to encode color inside real-world object regions. For this analysis, we use natural image datasets which provide pre-segmented object regions and surfaces.
Comparative Modeling of Human Tyrosinase - an Important Target for Developing Skin Whitening Agents

Abstract Human tyrosinase (hTyr) catalyzes the first and rate limiting step in the biosynthesis of a skin color determinant, melanin. Although a number of cosmetic companies have tried to develop hTyr inhibitors for severaldecades, absence of 3D structure of hTyr make it impossible to design or screen inhibitors by structure-based approach. Therefore, we built a 3D structure by comparative modeling technique based on the crystal structure of tyrosinase from Bacillus megaterium to provide structural information and to search new hit compounds from database. Our model revealed that two copper atoms of active site located deep inside and were coordinated withsix strictly conserved histidine residues coming from four-helix-bundle. Substrate binding site had narrow funnel likeshape and its entrance was wide and exposed to solvent. In addition, hTyr-tyrosine and hTyr-kojic acid, a well-knowninhibitor, complexes were modeled with the guide of solvent accessible surface generated by in-house software. Our model demonstrated that only phenol group or its analogs could fill the binding site near the nuclear copper center,because inside of binding site had narrow shape relatively. In conclusion, the results of this study may provide helpfulinformation for designing and screening new anti-melanogenic agents. 요 약
Persistence Maintenance of Nonresolving Inflammation and Papilloma Mediated Downregulation of LXA 4 Is Necessary for the −

Nonresolving inflammation is a hallmark of many types of tumors and themolecularmechanismsmaintaining this inflammation are still largely unknown. In a two-stage carcinogenesismodel, we observed here that the lack of IFN-g receptor or neutralization of IFN-g accelerated spontaneous papilloma regression in mice. The impaired maintenance of local inflammation was associated with reduced IFN-g and enhanced biosynthesis of proresolution lipid mediator lipoxin A4 (LXA4). Interestingly, blocking LXA4 eliminated the effect of anti-IFN-g , whereas treatment of mice with a therapeutic dose of LXA4 accelerated papilloma regression in an IFN-g–independent manner. These results link for the first time a cytokine-dependent maintenance of inflammation with a downregulated production of proresolution lipid mediators. Strategies promoting spontaneous resolution of chronic inflammation by blocking IFN-g and/or increasing LXA4 may be useful for the treatment of inflammation-associated tumors. Cancer Res; 73(6); 1742–51. 2012 AACR.