Miracle-dz/UniFAR-FTUs huggingface dataset:
Impetus to Transform: Essential Nursing Leadership Development through Simulation

A nurse manager’s ability to effect positive change and inspire others to higher levels of achievement is related to his or her leadership style in the practice setting, as well as the culture present in the organization as a whole. The aim of this Doctor of Nursing evidence-based change in practice project was to create an educational modality that supported training nurse leaders through innovation and creative problem solving in today’s acute healthcare setting. A survey was administered to 48 frontline managers in a Northern California healthcare system to access the gaps and voids in their ability to integrate transformational leadership as a model for performance. Survey results guided a process for manager development in the domains of execution competencies of accountability, change leadership, impact and influence/team building, and organizational awareness. The learning modality selected for this leadership development was the use of simulation scenarios that incorporated the four identified elements from the survey results to augment didactic transformational knowledge. Simulation has been positively associated with the development of transformational leadership skills. An evidencebased business case demonstrates the outcomes, including the return on investment for the retention of nurse managers in a role that has seen a high turnover in this Northern California healthcare system. The manager, adept in transformational leadership skills, can drive the alignment of staff at the unit level to establish a culture that offers patient quality care in a safe environment.
2-[3-Methoxy-5-(pyrimidin-2-yl)phenyl]pyrimidine

The title compound, C15H12N4O, was synthesized by a standard Suzuki cross-coupling reaction. The terminal pyrimidine rings are rotated at dihedral angles of 12.06 (4) and −13.13 (4)° with respect to the central benzene ring. In the crystal, the molecules are connected by two kinds of C—H⋯N hydrogen bonds, forming zigzag chains along the c axis. Weak π–π interactions between the benzene and one of the pyrimidine rings are also found and stack the molecules along the b axis [centroid–centroid distance = 4.112 (3) Å].
2-(4-Fluoroanilino)-3-(2-hydroxyethyl)quinazolin-4(3H)-one

The molecular and crystal structures of the title compound, C16H14FN3O2, are stabilized by intramolecular N—H⋯O and intermolecular O—H⋯O hydrogen bonds. The existence of non-classical intramolecular C—H⋯N hydrogen bonds provides a dihedral angle between the fluoro-substituted benzene and pyrimidinone rings of 7.9 (1)°.
Poly[bis(ethanol)(μ4-2,3,5,6-tetrafluorobenzene-1,4-dicarboxylato)cadmium]

In the title compound, [Cd(C8F4O4)(C2H5OH)2]n, the CdII cation sits on an inversion centre and is coordinated by six O atoms from four tetrafluorobenzene-1,4-dicarboxylate anions and two ethanol molecules in a distorted octahedral geometry. The anionic ligand is also located on an inversion centre, and connects four CdII cations, generating a two-dimensional polymeric layer parallel to the ab plane. Within the layer, the ethanol molecule links F and O atoms of the nearest anionic ligands via O—H⋯O and O—H⋯F hydrogen bonds. The ethyl group of the ethanol molecule is disordered over two positions with an occupancy ratio of 0.567 (10):0.433 (10).
2-(4-Fluorophenyl)-5,6-methylenedioxy-3-methylsulfinyl-1-benzofuran

In the title compound, C16H11FO4S, the O atom and the methyl group of the methylsulfinyl substituent are located on opposite sides of the mean plane through the 5,6-(methylenedioxy)benzofuran fragment. The 4-fluorophenyl ring is rotated out of the 5,6-(methylenedioxy)benzofuran plane, making a dihedral angle of 29.90 (6)°. In the crystal structure, both intermolecular C—H⋯O hydrogen bonds link the molecules into centrosymmetric dimers. The combination of C—H⋯O hydrogen bonds result in chains running along [1 ].
(3R*,6R*,4′S*,8′R*,3′′R*,6′′R*)-3,3′′-Diisopropyl-6,6′′-dimethyl-2′,6′-diphenyldispiro[cyclohexane-1,4′-(3,7-dioxa-2,6-diazabicyclo[3.3.0]octane)-8′,1′′-cyclohexane]-2,2′′-dione

The two oxazolidine rings (A and B) of the title compound, C34H44N2O4, display roughly half-chair conformations, which could be described as twisted on the C—O bond. Together, the fused oxazolidine rings have a butterfly shape, with the H atoms attached to the ring junction C atoms in a cis orientation. The cyclohexane rings of both p-menthone fragments display chair conformations. The absolute configuration could not be determined from the X-ray diffraction data, but the relative configuration of the stereocentres could be deduced.
A Scalable , Accurate and Extensible Network Emulation Platform using the IXP 1200 Network Processor

Emulab, the Utah Network testbed, is a large-scale emulation environment available to researchers all over the world. Through automated experiment configuration, and features such as dynamically changing link, router, and traffic characteristics, Emulab brings much of a simulator’s ease of use and control to emulation while retaining its realism. PCs serve many roles in the testbed: as end-hosts in an emulated distributed system, as traffic generation and consumption nodes, as routers in the emulated topology, and as link emulator nodes. As link emulators, their capacity is limited to 1 or 2 100 Mb ethernet lines per box, largely due to PCI bus arbitration overhead which negatively impacts scaling to large topologies. In this proposal, we address the problem of scalability, and accuracy under high loads, of link and router emulation by using the IXP series of network processors as an emulation platform. The IXP’s highly parallelized architecture along with special hardware units for common packet processing tasks enable packet forwarding at high rates with enough headroom for network emulation. We expect to be able to emulate a larger number of links and routers with a greater aggregate network bandwidth on a software emulation platform using the IXP1200 as compared to a modern PC class workstation. We will validate this claim by designing and implementing such an emulator on the IXP1200 network processor.
Dichloridodimethylbis(thiourea-κS)tin(IV)

The title compound, [Sn(CH3)2Cl2(CH4N2S)2], crystallizes with two half-molecules in the asymmetric unit. Both molecules are completed by inversion symmetry with the two SnIV atoms located on inversion centers. The metal atoms have distorted octahedral coordination environments defined by two Cl atoms, two C atoms of methyl groups and two thiourea S atoms. In the crystal, molecules are linked via N—H⋯Cl and N—H⋯S hydrogen bonds, forming a three-dimensional structure.
3-Chloro-6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazine

In the title compound, C9H9ClN4, the dihedral angle between the aromatic rings is 6.25 (9)°. The whole molecule is approximately planar (r.m.s. deviation = 0.070 Å). In the crystal, π–π interactions between the centroids of the pyridazine rings [separation = 3.5904 (10) Å] occur.
Another advantage of free choice (Extended Abstract): Completely asynchronous agreement protocols

Recently, Fischer, Lynch and Paterson [3] proved that no completely asynchronous consensus protocol can tolerate even a single unannounced process death. We exhibit here a probabilistic solution for this problem, which guarantees that as long as a majority of the processes continues to operate, a decision will be made (Theorem 1). Our solution is completely asynchronous and is rather strong: As in [4], it is guaranteed to work with probability 1 even against an adversary scheduler who knows all about the system.
2-(4-Bromophenyl)-3-(4-hydroxyphenyl)-1,3-thiazolidin-4-one

In the title compound, C15H12BrNO2S, the dihedral angle between the two aromatic rings is 87.81 (8)°. The five-membered thiazolidine ring has an envelope conformation, with the S atom displaced by 0.4545 (7) Å from the mean plane of the other four ring atoms. The crystal structure exhibits O—H⋯O, C—H⋯O, C—H⋯Br and C—H⋯ π interactions.
1-(Benzothiazol-2-yl)-3-(4-nitrobenzoyl)thiourea

The molecule of the title compound, C15H10N4O3S2, is almost planar (r.m.s. deviation = 0.1Å for all non-H atoms). An intramolecular N—H⋯O=C hydrogen bond is observed. In the crystal, molecules are connected into layers parallel to (10) by a classical intermolecular hydrogen bond from the second NH group to a nitro O atom and by three weak hydrogen bonds of the C—H⋯X type (X = O or Sthione).
1-(Butan-2-ylidene)-2-(2-nitrophenyl)hydrazine

Crystals of the title compound, C10H13N3O2, were obtained from a condensation reaction of butan-2-one and 1-(2-nitrophenyl)hydrazine. The molecule exhibits a nearly coplanar structure, except for the methyl and methylene H atoms, the largest deviations from the mean plane defined by all non-H atoms, except for the nitro group, being 0.120 (2) Å for one of the nitro O atoms. Intramolecular N—H⋯O hydrogen bonding helps to establish the molecular configuration.
1,5-Bis(4-nitrophenoxy)pentane

The title compound, C17H18N2O6, crystallizes with two molecules in the asymmetric unit. In both molecules, one of the C—C bonds of the pentamethylene chain connecting the two aromatic rings is in a trans conformation and another displays a gauche conformation. The aromatic rings within each molecule are nearly coplanar [dihedral angles = 3.36 (9) and 4.50 (9)°] and the nitro groups are twisted slightly out of the planes of their attached rings [dihedral angles = 8.16 (3)/6.6 (2) and 4.9 (4)/3.8 (3)°].
(Z)-3-(2-{2-[1-(4-Hydroxyphenyl)ethylidene]hydrazin-1-yl}-1,3-thiazol-4-yl)-2H-chromen-2-one

In the title compound, C20H15N3O3S, an intramolecular C—H⋯O hydrogen bond generates an S(6) ring motif. The chromene ring system is inclined at dihedral angles of 14.21 (9) and 9.91 (10)°, respectively, with respect to the thiazole and benzene rings. The thiazole ring makes a dihedral angle of 24.06 (11)° with the benzene ring. In the crystal structure, O—H⋯O hydrogen bonds link the molecules into a zigzag chain along [20]. Weak N—H⋯O and C—H⋯O interactions connect the chains into a three-dimensional network. π–π stacking interactions with a centroid–centroid distance of 3.4209 (14) Å are also observed between the chains.
4-[(E)-4-Methoxybenzylideneamino]-3-{1-[4-(2-methylpropyl)phenyl]ethyl}-1H-1,2,4-triazole-5(4H)-thione

In the title compound, C22H26N4OS, the benzene rings of the (2-methylpropyl)phenyl and 4-methoxyphenyl units form dihedral angles of 66.85 (3) and 25.96 (3)°, respectively, with the triazole ring. The dihedral angle between the two benzene rings is 87.42 (2)°. The –CH(CH3) linkage is disordered over two orientations with occupancies of 0.907 (3) and 0.093 (3). An intramolecular C—H⋯S hydrogen bond generates an S(6) ring motif. Intermolecular N—H⋯S hydrogen bonds and C—H⋯π interactions are observed.
2-Ethoxy-6-[(methylimino)methyl]phenol

In the title compound, C10H13NO2, synthesized by the reaction of 2-hydroxy-3-ethoxybenzaldehyde with methylamine, there is an an intramolecular O—H⋯N hydrogen bond involving the hydroxy substituent and the amino N atom. In the crystal, molecules form inversion dimers connected by pairs of C—H⋯O hydrogen bonds.
The struggles and triumphs of non-offending mothers in dealing with the sexual abuse of their children : an exploratory study.

Child abuse continues to be a major challenge in South Africa. Much of the research has focused on helping children who have been abused and more recently focus has been placed on the perpetrator. Understanding the needs of the mother of the abused child has largely been neglected. This study explored how mothers of abused children are also affected by the child's trauma and how her survival contributes to the healing of the family. Using a qualitative research approach, data was gathered from case files, groupwork notes and in-depth interviews with eight women whose children had been abused. A feminist approach guided the study. This research described the experiences of women and provided insight into their struggles and triumphs as they assisted their children in the healing process.
5-(4-Hydroxybenzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

The title compound, C13H12O5, was prepared by the reaction of 2,2-dimethyl-1,3-dioxane-4,6-dione and 4-hydroxybenzaldehyde in ethanol. The 1,3-dioxane ring is in a distorted boat conformation. In the crystal, inversion dimers linked by pairs of O—H⋯O hydrogen bonds generate R 2 2(20) rings.
2-{[(4-{[(2-Hydroxyphenyl)(phenyl)methylidene]amino}phenyl)imino](phenyl)methyl}phenol

The title molecule, C32H24N2O2, has a crystallographically imposed inversion centre and exists in the crystal as an enol–imine tautomer. The molecular structure is stabilized by two strong intramolecular O—H⋯N hydrogen bonds. The dihedral angles between the central benzene ring and the mean planes of the phenyl substituents are 59.99 (1) and 62.79 (2)°. In the crystal, the molecules are arranged into (010) layers via C—H⋯π interactions.
2-(1,2,3,4-Tetrahydro-9H-carbazol-1-ylidene)propanedinitrile

In the title compound, C15H11N3, the cyclohexene ring adopts a sofa conformation. An intramolecular N—H⋯N hydrogen bond generates an S(7) ring motif. In the crystal, molecules are linked by intermolecular N—H⋯N, C—H⋯N and C—H⋯π interactions into a three-dimensional network.
5-{[(E)-2-(4-Iodophenyl)hydrazinylidene]methyl}thiophene-2-carbaldehyde

The title compound, C12H9IN2OS, has an overall U-shape, with a dihedral angle of 21.4 (3)° between the thiophene and benzene rings. In the crystal, supramolecular chains mediated by N—H⋯O hydrogen bonds are formed along the b-axis direction.
Perioperative care of phaeochromocytoma

### Key points Phaeochromocytomas are catecholamine-secreting tumours of the adrenal medulla, while paragangliomas are closely related neuroendocrine tumours arising from extra-adrenal paraganglia, some of which produce catecholamines. In this article, their perioperative management will be considered together. The majority develop sporadically, although around one-third of cases have specific gene mutations which are usually inherited in an autosomal-dominant fashion. These may be associated with other tumours, for example, multiple endocrine neoplasia 2A and 2B, Von Hippel–Lindau disease, succinate dehydrogenase enzyme mutations, and neurofibromatosis. The annual European incidence rate of phaeochromocytomas is around 0.2 per 100 000 people. The traditional ‘Rule of 10s’ states that 10% of phaeochromocytomas are ‘extra-adrenal’, 10% are malignant, 10% are bilateral, 10% are found in normotensive patients, and 10% are familial. However, this statement probably no longer holds true as there appears to be a significantly higher proportion of tumours that are malignant (29%),1 extra-adrenal (24%),2 and/or familial (32%). 3 Phaeochromocytomas may present with a classic symptom triad of headache, palpitations, and sweating. Hypertension is present in around 90% of cases, although it is paroxysmal in 35–50% of these. Other non-specific presentations include anxiety, lethargy, nausea, weight loss, hyperglycaemia, and tremor. Abdominal pain may result from bowel ischaemia due to excessive vasoconstriction. Visual disturbance may develop from papilloedema induced by malignant hypertension. Half of phaeochromocytomas are diagnosed incidentally on abdominal imaging for an unrelated indication. Phaeochromocytomas produce a variable mixture of norepinephrine, epinephrine, or, more rarely, dopamine. Traditional biochemical diagnosis of phaeochromocytomas relied upon 24 h collections …
Systematic analysis of crosstalk in the PDGF receptor signal transduction network

WANG, CHUN-CHAO. Systematic Analysis of Crosstalk in the PDGF Receptor Signal Transduction Network. (Under the direction of Jason M. Haugh.) Intracellular signal transduction is traditionally characterized in terms of pathways, comprised of serial activation processes. Although it is appreciated that canonical signaling pathways are simply dominant routes of regulation embedded in larger interaction networks, relatively little has been done to quantify pathway crosstalk in such networks. Through quantitative measurements that systematically canvas an array of stimulation and molecular perturbation conditions, together with computational modeling and analysis, we have elucidated crosstalk mechanisms in the platelet-derived growth factor (PDGF) receptor signaling network, in which phosphoinositide 3-kinase (PI3K) and Ras/extracellular signal-regulated kinase (Erk) pathways are prominently activated. We show that, while PI3K signaling is insulated from crosstalk, PI3K enhances Erk activation in multiple ways. Whereas simultaneously blocking Ras and PI3K abolishes PDGF-stimulated Erk phosphorylation, each pathway makes an independent contribution to Erk activation, and PI3K affects Ras activation as well. The magnitudes of these effects depend strongly on the stimulation conditions, subject to saturation effects in the respective pathways and negative feedback loops. Motivated by those dynamics, a kinetic model of the network was formulated and used to precisely quantify the relative contributions of PI3K-dependent and -independent modes of Ras/Erk activation. Systematic Analysis of Crosstalk in the PDGF Receptor Signal Transduction Network by Chun-Chao Wang A dissertation submitted to the Graduate Faculty of North Carolina State University in partial fulfillment of the requirements for the Degree of Doctor of Philosophy Chemical Engineering Raleigh, North Carolina 2008
2-Amino-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile

In the title compound, C10H12N2S, one of the C atoms of the cyclohexene ring (at position 6) and the methyl group attached to it are disordered over two sets of sites in a 0.650 (3):0.350 (3) ratio. The cyclohexene ring in both the major and minor occupancy conformers adopts a half-chair conformation. The thiophene ring is essentially planar (r.m.s. deviation = 0.05 Å). In the crystal, N—H⋯N hydrogen bonds involving the amino groups result in inversion dimers with R 2 2(12) graph-set motif. Further N—H⋯N hydrogen bonds involving the amino and carbonitrile groups generate zigzag chains along the a axis.
3-(3,4-Dichlorobenzylidene)chroman-4-one

The distinctive feature of the structure of the title compound, C16H10Cl2O2, is the formation of a zigzag chain along [100] via Cl⋯Cl interactions [3.591 (1) and 3.631 (1) Å]. The chromanone moiety is fused with the benzene ring and adopts a half-chair conformation. The dihedral angle between the benzene ring of the chromanone moiety and the dichlorobenzene plane is 56.14 (8)°.
(2-Hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)methanone

The title compound, C14H12O4, is an asymmetric substitution product of benzophenone. Both hydroxy groups are orientated towards the O atom of the keto group. Intramolecular as well as intermolecular O—H⋯O hydrogen bonds can be observed in the crystal structure, with the latter connecting the molecules into chains along the crystallographic b axis. C—H⋯O contacts [C⋯O = 3.3297 (18) Å] are also apparent. The closest centroid–centroid distance between two aromatic systems is 4.9186 (9) Å.
3-Anilino-1-(isopropylamino)propan-2-ol

The title compound, C12H20N2O, was obtained by the reaction of N-(oxiran-2-ylmethyl)aniline and propan-2-amine. In the crystal, molecules are linked by O—H⋯N and N—H⋯O hydrogen bonds into chains parallel to the b axis.
2-(4-Bromophenyl)-N-(5-methylpyridin-2-yl)acetamide

The asymmetric unit of the title compound, C14H13BrN2O, consists of two molecules; the dihedral angles between the pyridine and benzene rings are 87.99 (9) and 84.28 (9)°. An intramolecular C—H⋯O hydrogen bond generates an S(6) ring in each molecule. In the crystal, molecules are linked via N—H⋯N and C—H⋯O hydrogen bonds into a three-dimensional network. The crystal structure also features weak π–π stacking interactrions between the benzene rings [centroid-to-centroid distance = 3.6829 (12) Å].
2-(4-Chloro-3-nitrophenyl)-4-(4-chlorophenyl)-1,3-thiazole

The title compound, C15H8Cl2N2O2S, crystallizes with two molecules in the asymmetric unit. The dihedral angles between the 4-chloro-3-nitrophenyl ring and the thiazole ring are 0.5 (1) and 7.1 (1)° and those between the 4-chlorophenyl ring and the thiazole ring are 7.1 (1) and 7.4 (1)° in the two molecules. The crystal structure is stabilized by intermolecular C—H⋯Cl and C—H⋯O hydrogen bonds.
3-(4-Bromophenyl)cyclopent-2-en-1-one

In the title compound, C11H9BrO, the cyclopentenone ring is almost planar with an r.m.s. deviation of 0.0097 Å. The largest inter-ring torsion angles [2.4 (3), 1.3 (3) and 3.53 (2)°] reveal only a very small twist between the rings, and suggest that the two rings are conjugated. The molecule is slightly bowed, as shown by the small dihedral angle between the rings [5.3 (1)°]. The crystal packing pattern consists of parallel sheets that stack parallel to the ac plane. Each sheet consists of molecules that pack side-to-side with the same relative orientation of phenyl and cyclopentenone rings along the a- and c-axis directions. Slipped side-to-side, face-to-face and edge-to-face interactions exist between pairs of sheets with edge-to-edge and edge-to-face O⋯H—C(sp 2) weak hydrogen-bond contacts. A relatively short edge-to-face contact (2.77 Å) also exists between pairs of sheets.
EDUCACIÓN EN SALUD: EN LA BÚSQUEDA DE METODOLOGÍAS INNOVADORAS HEALTH EDUCATION: IN SEARCH OF INNOVATIVE METHODOLOGIES

Health education is a complex process that requires the incorporation of knowledge, skills, attitudes and values required to train professionals in the area, as well as strategies for a comprehensive assessment of the skills acquired. The aim of this review is to determine the existing state of the art regarding the use of innovative methodologies in learning and development evaluation of clinical skills in the area of health. The literature review include methodologies such as Objective Structured Clinical Examination, Instruction and Computer-assisted learning, Learning programs based on Internet, Multimedia computer-based programs and Virtual reality simulation, whose approach to education allows students to apply and integrate knowledge newly acquired and clinical experience, in order to generate greater security and confidence prior to actual patient arrival. These methods encourage self-confidence in the nursing students to be conducive to learning technologies in a secure environment, leading to high clinical performance, academic and satisfaction with the course. Another important point is that these technologies enable the development of cognitive strategies rather
Correlation of Arterial Stiffness and the extent of Somatic DNA Damage in Cardiometabolic Syndrome

This study was conducted to evaluate the correlation of arterial stiffness and the extent of somatic DNA damage by Cytokinesis-Block Micronuclei Assay in patients with cardio-metabolic syndrome. Fifty two patients with cardiometabolic syndrome and fifty two normal, healthy controls were included in this study. The arterial stiffness was accessed by various physiologic and biochemical factors such as heart rate, pulse pressure, systole, diastole, augmentation index, HDL, LDL etc. Both male and female subjects those reported cardiometabolic syndrome had abnormal range of physiologic and biochemical characteristics along with increased DNA damage. Significantly elevated augmentation index (34.62±11.46) was observed among the study subjects than the control subjects (8.67±1.08). The mean CBMN frequency of the study subjects was found to be 14.12±0.53, which is higher than the control subjects (10.33±0.70). These findings clearly demonstrate a significant correlation between arterial stiffness/augmentation index and the extent of DNA damage in cardiometabolic syndrome subjects and hence lifestyle modification with proper food, exercise and medication will help to reduce the arterial stiffness/augmentation index and the risk for cardiometabolic syndrome.