Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification of candidate genes related to pancreatic cancer based on analysis of gene co-expression and protein-protein interaction network

Pancreatic cancer (PC) is one of the most common causes of cancer mortality worldwide. As the genetic mechanism of this complex disease is not uncovered clearly, identification of related genes of PC is of great significance that could provide new insights into gene function as well as potential therapy targets. In this study, we performed an integrated network method to discover PC candidate genes based on known PC related genes. Utilizing the subnetwork extraction algorithm with gene co-expression profiles and protein-protein interaction data, we obtained the integrated network comprising of the known PC related genes (denoted as seed genes) and the putative genes (denoted as linker genes). We then prioritized the linker genes based on their network information and inferred six key genes (KRT19, BARD1, MST1R, S100A14, LGALS1 and RNF168) as candidate genes of PC. Further analysis indicated that all of these genes have been reported as pancreatic cancer associated genes. Finally, we developed an expression signature using these six key genes which significantly stratified PC patients according to overall survival (Logrank p = 0.003) and was validated on an independent clinical cohort (Logrank p = 0.03). Overall, the identified six genes might offer helpful prognostic stratification information and be suitable to transfer to clinical use in PC patients.
and Christophe Left Atrial Volume and Mortality in Patients With Aortic Stenosis

Methods and Results-—We included 1351 patients with AS in sinus rhythm at diagnosis and analyzed the occurrence of all-cause death during follow-up with medical and surgical management. Five parameters of LA enlargement were tested: nonindexed LAV and normalized LAV by ratiometric (LAV/body surface area [BSA] and LAV/height) and allometric (LAV/BSA and LAV/height) scaling. For each parameter, patients in the highest quartile were at high risk of death, whereas outcome was better and similar for the other quartiles. Five-year survival was lower for patients with LAV >95 mL and LAV/BSA >50 mL/m compared with those with no or mild LA enlargement (both P<0.001). After adjustment for established outcome predictors, including surgery, high risk of death was observed with LAV >95 mL (adjusted hazard ratio, 1.40 [95% confidence interval, 1.06–1.88]) and LAV/BSA >50 mL/ m (adjusted hazard ratio, 1.42 [95% confidence interval, 1.08–1.91]). LAV/BSA and LAV showed good and similar predictive performance, whereas other scaling methods did not show better outcome prediction. In patients with severe AS at baseline, preserved (≥50%) ejection fraction, and no or minimal symptoms, LA enlargement was significantly associated with mortality (adjusted hazard ratio, 1.87 [95% confidence interval, 1.02–3.44] for LAV >95 mL, and adjusted hazard ratio, 1.90 [95% confidence interval, 1.03–3.56] for LAV/BSA >50 mL/m).
A discriminative dictionary learning-AdaBoost-SVM classification method on imbalanced datasets

Sparse representation is a signal processing method which is mostly used in signal compression, noise reduction, and signal and image restoration fields. In this study, sparse representation was used in a different way from the traditional methods. In the proposed method, a hybrid structure was created by combining dictionary learning and ensemble classifier AdaBoost algorithms. The main idea of this method is to obtain the sparse coefficients from an over-complete dictionary and to use the coefficients in the weight update formula of AdaBoost. Support Vector Machines (SVM) classifier was used as weak classifiers of AdaBoost, and AdaBoost-SVM classifier structure was created. Multiplying the sparse coefficients with weight of weak learners process in weight update formula has given satisfying results on imbalanced datasets during the experiments.
Lecithin/sphingomyelin ratio and lamellar body count. What values predict the presence of phosphatidylglycerol?

OBJECTIVE To assess which values of the lecithin/sphingomyelin (L/S) ratio and lamellar body count (LBC) optimally correspond to the presence of phosphatidylglycerol (PG). STUDY DESIGN A database of clear amniotic fluid specimens obtained by amniocentesis was accessed. Receiver operating characteristic curve analysis was performed for both L/S ratio and LBC to identify the optimal thresholds for predicting the presence of PG. RESULTS One hundred eighty-eight patients were included in the analysis. "Trace" PG was more like "absent" PG in relation to both L/S ratio and LBC. There were significant relationships between L/S ratios and presence of PG (area under the curve = .909, P < .0001) and between LBC and presence of PG (area under the curve = .94, P < .0001). The positive predictive value of L/S ratio > 2 was 76%, and that of LBC > 30,000 was 82% in predicting the presence of PG. Optimal threshold values for the prediction of PG presence were > 3.0 for L/S ratio, which had a positive predictive value of 95% and false positive rate of 5%, and > 50,000 for LBC, with a 96% positive predictive value and 5% false positive rate. CONCLUSION "Mature" results for PG in amniotic fluid are equivalent to an L/S ratio of > 3.0 and LBC > 50,000 and help explain the later gestational age at the appearance of lung maturity by PG than by L/S > 2 or LBC > 30,000.
Multi-level switching of triple-layered TaOx RRAM with excellent reliability for storage class memory

A highly reliable RRAM with multi-level cell (MLC) characteristics were fabricated using a triple-layer structure (base layer/oxygen exchange layer/barrier layer) for the storage class memory applications. A reproducible multi-level switching behaviour was successfully observed, and simulated by the modulated Schottky barrier model. Morevoer, a new programming algorithm was developed for more reliable and uniform MLC operation. As a result, more than 107 cycles of switching endurance and 10 years of data retention at 85°C for all the 2 bit/cell operation were archieved.
Factors predictive of corticosteroid psychosis in patients with systemic lupus erythematosus

Corticosteroid-induced psychosis occurred in 5% of a prospective cohort of 92 patients with systemic lupus erythematosus (SLE). Psychosis was unpredictable by the routes and dosage of corticosteroid used. Factors predictive of psychosis were low serum levels of albumin, complement, and creatinine; history of anxiety disorders; and a family history of psychiatric illnesses. After multivariate adjustment, only hypoalbuminemia remained significant.
CEREBELLAR BLOOD FLOW IN MAN.

Recently a method for determination of regional cerebral blood flow in man has been described. 1 The method is based on the use of a freely diffusible radioactive indicator. Radioactive krypton 85 (Kr 85 ) dissolved in saline was injected into the carotid artery, and the build-up and subsequent clearance of radioactivity from the brain were followed by a scintillation detector. In a small series of normal subjects the blood flow over the frontal and temporal regions of the hemispheres was about 0.65 ml/gm/min. Low values of about 0.35 ml/gm/min were found over the same regions in patients with dementia due to cerebrovascular disease. The present report concerns the results of application of the inert gas injection method to the vertebral artery system in order to study the blood flow in the cerebellum. Material and Methods Seven hospital patients without clinical evidence of cerebellar diseases were studied. In Table 1 the
Exploiting Mechanical Flexure as a Means of Tuning the Responses of Large-Scale Periodic Structures

We present techniques for designing large-scale, mechanically tunable periodic structures (PSs). Overlapping combined with relative movement, stretching/compression, and flexure are the three mechanical tuning techniques studied in this paper. We demonstrate that all of these mechanical movements may be used to tune the capacitance and inductance of elementary periodic structures with capacitive and inductive surface impedances over wide ranges of values. Analytic formulas for calculating the variable inductance and capacitance of these tunable PSs are also provided. These elementary PSs are the building blocks of a wide range of other PSs with more complicated unit cells and response types. One such structure-a frequency selective surface (FSS) composed of series combination of these inductive and capacitive structures-is also examined to demonstrate the application of the proposed tuning and analysis concepts. The FSS is fabricated on an accordion-like substrate that can be contracted or stretched to change its frequency of operation. The response and tuning properties of this structure are experimentally characterized using a free-space measurement system. A very good agreement between theory and experiment is obtained. This demonstrates that the behavior of such complex mechanically tunable PSs can be analyzed by examining the behavior of their constitutive inductive and capacitive elements.
History-based reintegration of replicated shared workspaces

Replication of shared workspaces is often required for continuous work during decoupled connectionless phases. In distributed cooperative teams, the decoupled phases are mainly long and should be supported by an optimistic strategy which guarantees unlimited concurrent work by allowing different modifications on each replica. This approach leads to inconsistent versions which must be transformed into a single version during reintegration before coupled work begins. This paper describes the basic mechanisms and the realization of a generic MARC (Merge And Resolve Conflicts) component providing history-based reintegration. The component uses operations on an object-oriented data model and defines conflicts in terms of operations as representation of inconsistencies. The conflict resolution is supported by a conflict detection, a template-based presentation, an interactive decision selection and the execution of correction operations. Furthermore, conflict dependencies and anomalies of conflicts with directed links are handled generically by an adaptation of decision options in special situations.
Inherent limitations in high frequency surface wave radar remote sensing based on Bragg scattering from Gaussian rough surfaces

An examination of the fluctuation in the Bragg spectral peaks in HF radar spectra of ocean backscatter is considered in the light of recent cross section models. It is well known that there are likely several factors giving rise to this phenomenon. Here we examine the effect which is caused purely in the context of a pulse Doppler radar being used to gather information from a time-varying random rough surface representable as a zero-mean, Gaussian random process. The finite width of the Bragg peak is presented as appearing naturally in the first-order cross section and the contribution to the power spectrum at each Doppler frequency point is seen to be affected by that at neighboring points.
Intimacy-Scaled Stimuli for Use in Studies of Interpersonal Relations

Psychometric materials for use in research on interpersonal exchange and self-disclosure included 671 statements about various aspects of the self which people might discuss as they form interpersonal relationships with others. Items were scaled for “intimacy” and topical category by judges from two different populations. From equal-appearing interval analysis were obtained intimacy scale values and Q-scores. Pearson product-moment correlations showed high agreement between the two populations. The validation of a priori category nomenclature indicated that placements of 497 out of 671 statements were agreed upon by at least 8 of 16 judges. An additional 20 statements were reliably categorized by judges in other than the originally assigned topic areas. Thus, there was reliable agreement among judges as to statement topic for 77% of the items. Advantages and suggested usages of the item pool were discussed.
What features improve the accuracy of clinical diagnosis in Parkinson's disease

Many authorities have drawn attention to the difficulties in clinically distinguishing Parkinson's disease (PD) from other parkinsonian syndromes. We assessed the clinical features of 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic PD according to their pathologic findings. Seventy-six percent of these cases were confirmed to have PD. By using selected criteria (asymmetrical onset, no atypical features, and no possible etiology for another parkinsonian syndrome) the proportion of true PD cases identified was increased to 93%, but 32% of pathologically confirmed cases were rejected on this basis. These observations suggest that studies based on consultant diagnosis of PD, using standard diagnostic criteria, will include cases other than PD, thus distorting results from clinical trials and epidemiologic studies. The strict use of additional criteria can reduce misdiagnosis but at the cost of excluding genuine PD cases.
Post‐traumatic stress disorder in Dohuk, Kurdistan

In this issue of Acta Paediatrica, Ahmed Abdolbaghi presents data from school children in the City of Dohuk in the Kurdish part of Iraq (1). According to the results, onethird of the children endorse criteria for post-traumatic stress disorder (PTSD). This prevalence rate is very high, but there is no reason to question the validity of the study. The participation rate is extraordinarily high for such a study, and the prevalence has been reported to be higher in other sites such as Rwanda (2) and Bosnia (3). What we do not know is the aetiology of PTSD in the present material. The possible reasons, according to the author, are war experiences, traffic accidents, maltreatment or witnessing violence. The Kurdish part of Iraq has been one of the most violent places in the world during the reign of Saddam Hussein. The invasion of Iraq has, however, made things even worse, with the possible exception of the Kurdish parts of Iraq, where the Dohuk region is one example of increasing order and relative peace where it is possible to carry out public health assessments without risking your life. However, the parents of the children in the study have been subjected to war, terror and injustice for their lifetime. A high number of these parents must have been traumatized, with PTSD and depression rates of the same or higher order as found in their children. The conclusion is that psychological trauma and its sequelae, somatoform and psychoform dissociation, PTSD and secondary mental and somatic illness, must be a major public health problem in the country. This implies that a significant proportion of caretakers have problems with affect modulation, leading to aggression or withdrawal. Thus, a secure attachment cannot be presumed as often as is normally the case (4). PTSD also leads to cognitive problems for as long as the disorder exists (5,6). The problem is a formidable one since the restoration of the country cannot be done without
Meta-analysis of placebo responses in central neuropathic pain: impact of subject, study, and pain characteristics

Abstract The placebo response is a complex construct related to psychobiological effects, as well as natural history and regression to the mean. Moreover, patient and study design characteristics have also been proposed as significantly affecting placebo responses. The aim of the current investigation was to identify factors that contribute to variable placebo responses in clinical trials involving individuals with central neuropathic pain. To this end, we performed a systematic review and meta-analysis of placebo-controlled trials examining pharmacological and noninvasive brain stimulation interventions for central neuropathic pain. Study design, subject characteristics, and pain ratings for the placebo group were extracted from each trial. Pooling of results and identification of moderating factors were carried out using random effects meta-analysis and meta-regression techniques. A total of 39 published trials met the inclusion criteria (spinal cord injury, n = 26; stroke, n = 6; multiple sclerosis, n = 7). No significant publication bias was detected. Overall, there was a significant effect for placebo to reduce central pain (−0.64, CI: −0.83 to −0.45). Smaller placebo responses were associated with crossover-design studies, longer pain duration, and greater between-subject baseline pain variability. There were no significant effects for neurological condition (stroke vs multiple sclerosis vs spinal cord injury) or the type of intervention (eg, pharmacological vs noninvasive brain stimulation). In a planned subanalysis, the severity of damage in the spinal cord also had no significant effect on the placebo response. Further study is warranted to identify factors that may explain the impact of pain duration on the placebo response at the individual subject level.
Running Head : DELIBERATE SELF-HARM AND ALCOHOL Deliberate Self-Harm and Alcohol Involvement in College-Aged Females : A Controlled Comparison in a Non-Clinical Sample

Individuals who engage in deliberate self-harm (DSH) report using other problematic coping mechanisms. One potential problematic coping mechanism is alcohol consumption. Research on alcohol involvement and deliberate self-harm is conflicting. This study compared individuals who have engaged in deliberate self-harm to controls on a range of alcohol measures. Five hundred females completed questionnaires assessing deliberate self-harm and alcohol involvement. Controlling for differences in psychopathology and impulsivity, the DSH group did not differ from the controls relative to quantity and frequency of alcohol use, but did differ relative to negative consequences, risky behaviors, and alcohol expectancies. We discuss mechanisms that account for increased negative consequences and expectancies of alcohol consumption in the absence of differences in quantity and frequency, as well as the clinical importance of assessing a broad spectrum of alcohol involvement in the DSH population.
Design of random pulse-width modulated inverter with lower-order harmonic elimination

A random pulse-width modulated inverter based on programmed PWM with lower-order harmonics elimination is presented in this paper. In motor drive applications, the high switching frequencies often results in acoustic noises, which make operator feel uncomfortable. The programmed PWM are used to solve nonlinear equation eliminating harmonics with initial value obtained by equal area PWM to obtain the switching angle. More than 50 sets of switching patterns are solved by the proposed method to randomly sample at every period to generate PWM waveform. Random probability function is used to obtain the harmonic spectrum distribution by random sampling method to determine the output voltage waveforms. The harmonic spectrum is spread out to normalize the side-band harmonics and lower-order harmonics are eliminated significantly as well so that the EMI problems can be alleviated efficiently. In practical circuit implementation, the random selection of the solved PWM switching patterns results in different switching pattern and harmonic spectra at every period so that the concentrated sideband harmonic energy can be spread out
FCP1 Phosphorylation by Casein Kinase 2 Enhances Binding to TFIIF and RNA Polymerase II Carboxyl-terminal Domain Phosphatase Activity*

Dephosphorylation of RNA polymerase II carboxyl-terminal domain (CTD) is required to resume sequential transcription cycles. FCP1 (TFIIF-dependent CTD phosphatase 1) is the only known phosphatase targeting RNAP II CTD. Here we show that in Xenopus laevis cells, xFCP1 is a phosphoprotein. On the basis of biochemical fractionation and drug sensitivity, casein kinase 2 (CK2) is shown to be the major kinase involved in xFCP1 phosphorylation in X. laevis egg extracts. CK2 phosphorylates xFCP1 mainly at a cluster of serines centered on Ser457. CK2-dependent phosphorylation enhances 4-fold the CTD phosphatase activity of FCP1 and its binding to the RAP74 subunit of general transcription factor TFIIF. These findings unravel a new mechanism regulating CTD phosphorylation and hence class II gene transcription.
Development of a digital micromirror spectrometer for analytical atomic spectrometry.

A digital micromirror device (DMD) has been incorporated into a novel spectrometer for use in analytical atomic spectrometry. The device can be taken from a commercial computer projector. A protective glass window covering the DMD chip limits the viewable wavelengths to the visible range. The DMD is used to project an image of the light source onto the exit plane of a flat-field spectrograph. A single photomultiplier tube is used for detection. The high switching rate of the micromirrors (15 μs) enables rapid full-spectrum capture, wavelength-modulation, source-modulation, fast narrow-wavelength window scans, and rapid-wavelength "jumping. " Calcium, sodium, and potassium have been determined in several standard reference materials (tomato leaves, bovine liver, rice flour, total diet) by flame atomic absorption and emission spectrometry. Absorption sensitivities for each element are near the 0.02 μg/mL level, and detection limits for both absorption and emission are near the 0.01 μg/mL level. Elemental recoveries were within 10% of certified values for most reference materials.
A New Blind PAPR Reduction and Error Correction Method in OFDM System Using BCH Codes

Orthogonal frequency division multiplexing (OFDM) is an effective technique for high bit rate applications in wireless communication systems. Many researches have been carried out to improve OFDM efficiency. Advantages of OFDM system make this technique as the most favorable modulation scheme for digital audio and video broadcasting in Europe. Unfortunately OFDM has the drawback of potentially high peak to average power ratio (PAPR). In this paper we propose a new technique based on selective branch for reducing peak-to-average power ratio in OFDM systems. This new method uses BCH code, Interleaving and also Rapp's power amplifier model. In this technique it is not necessary to transmit side information to receiver for recovering original data. It is shown that in most situations this proposed technique also improves the effective bit error rate (BER).
Behavior Patterns of Physical Therapists in Screening for Loss of Protective Sensation in Clients with Diabetes

Abstract Peripheral neuropathy is a common consequence of diabetes that often results in loss of protective sensation. Early identification of this loss is critical to minimize secondary complications. The authors’ purpose was to assess the behavior patterns of physical therapists as to their opinions and behaviors related to sensory testing for individuals with diabetes. A questionnaire was sent to physical therapists across the United States with the following results: a high level of agreement concerning the benefits of sensory testing, but with a far less agreement as to the actual performance of sensory testing by those same physical therapists.
Reasoning about Translation Lookaside Buffers Syeda Hira Taqdees and Gerwin

The main security mechanism for enforcing memory isolation in operating systems is provided by page tables. The hardware-implemented Translation Lookaside Buffer (TLB) caches these, and therefore the TLB and its consistency with memory are security critical for OS kernels, including formally verified kernels such as seL4. If performance is paramount, this consistency can be subtle to achieve; yet, all major formally verified kernels currently leave the TLB as an assumption. In this paper, we present a formal model of the Memory Management Unit (MMU) for the ARM architecture which includes the TLB, its maintenance operations, and its derived properties. We integrate this specification into the Cambridge ARM model. We derive sufficient conditions for TLB consistency, and we abstract away the functional details of the MMU for simpler reasoning about executions in the presence of cached address translation, including complete and partial walks.