Miracle-dz/UniFAR-FTUs huggingface dataset:
Performance comparison of cascode GaN HEMT and Si MOSFET based inverter for motor drive applications

This paper presents a performance comparison of a cascode GaN HEMT and a Si MOSFET rated at 600 V which are used in a 1 kW three-phase inverter. The advantages and challenges of using GaN transistors in a motor drive application are discussed. Thermal simulations of a GaN and Si based inverter have been performed and experimental results of the switching performance and inverter efficiency using both device technologies are presented. The results show the high potential of GaN power devices in a motor drive application.
Investigation of SHANK3 in schizophrenia

The postsynaptic scaffolding protein SHANK3 is essential for the normal function of glutamatergic synapses in the brain. Emerging evidence suggests that impaired plasticity of glutamatergic synapses contributes to the pathology of schizophrenia (SCZ). To investigate whether variants in the SHANK3 gene contribute to the etiology of SCZ, we sequenced SHANK3 in 500 affected individuals (cohort C1). In total, we identified 48 variants and compared them to European controls from the 1000 Genomes Project and the Exome Variant Server. Five variants showed significant differences in frequencies between patients and controls. We were able to follow three of them up in an independent cohort (C2) comprising 993 SCZ patients and 932 German controls. We could not confirm an association for three of these variants (rs140201628, rs1557620, and rs61729471). Two rare variants with predicted functional relevance were identified in further SCZ individuals of cohort C1: c.3032G>T (p.G1011V) and c. *27C>T. The latter variant was found in one additional SCZ individual and the p.G1011V variant was identified in two additional SCZ individuals from cohort C2. The p.G1011V variant was the most interesting variant in our study; together with previous studies this variant has been identified in 4 out of 1,524 SCZ patients and in 4 out of 2,147 individuals with autism spectrum disorder (ASD), but not in 2468 European Sanger‐sequenced controls. Therefore, we consider this variant a promising candidate variant for follow‐up studies in larger samples and functional investigations. © 2017 Wiley Periodicals, Inc.
Complete mitochondrial genome of the Chinese hwamei (Garrulax canorus)

Abstract Chinese hwamei (Garrulax canorus) is native to Eastern Asia, which is a member of Leiothrichidae, Passeriformes. In this study, the complete mitochondrial genome of G. canorus was sequenced. The genome is 17 828 bp in length and consists of 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes and 2 control regions. Phylogenetic analysis demonstrated that the mitogenomic sequence of G. canorus was most closely related to the sequences from other species of Garrulax.
Gastroenteropancreatic Well-Differentiated Grade 3 Neuroendocrine Tumors: Review and Position Statement.

: In 2010, the World Health Organization (WHO) classification of neuroendocrine neoplasms was reviewed and validated the crucial role of the proliferative rate. According to the WHO classification 2010, gastroenteropancreatic neuroendocrine neoplasms are classified as well-differentiated neuroendocrine tumors (NETs) of grade 1 or 2 in up to 84%, or poorly differentiated neuroendocrine carcinomas in 6%-8%. Neuroendocrine carcinomas are of grade G. Recently, a proportion of neuroendocrine tumors presenting a number of mitoses or a Ki-67 index higher than 20% and a well-differentiated morphology have been identified, calling for a new category, well-differentiated grade 3 NET (NET G-3). Studies that have reported the characteristics of neuroendocrine neoplasms have identified more well-differentiated NET G-3 than neuroendocrine carcinomas. The main localizations of NET G-3 are the pancreas, stomach, and colon. Treatment for NET G-3 is not standardized and is balanced between G-1/2 neuroendocrine tumor and neuroendocrine carcinoma treatments. In nonmetastatic neuroendocrine tumors, the European and American guidelines recommended a surgical resection for localized neuroendocrine neoplasm, irrespective of the tumor grading. In NET G-3, chemotherapy is the benchmark if the main treatment goal is reduction of the tumor mass, particularly if it would allow a secondary surgery. In the present work, we review the epidemiology and make recommendations for the management of NET G-3. IMPLICATIONS FOR PRACTICE Neuroendocrine tumors presenting a number of mitoses or a Ki-67 index higher than 20% and a well-differentiated morphology have been identified and named well-differentiated grade 3 neuroendocrine tumors (NET G-3). The main localizations of NET G-3 are the pancreas, stomach, and colon. The prognosis is worse than that for NET G-2. In nonmetastatic NET G-3, surgery appeared to be the first option. The chemotherapy regimen in pancreatic NET G-3 should be in line with that implemented in NET G-1/2 when the Ki-67 index is below 55% and should be in line with that implemented for neuroendocrine carcinoma when Ki-67 is above 55%.
Mobile diffusion source tracking in sensor networks

Compared to the instantaneous mobile source tracking, the mobile diffusion source tracking is more difficult. In this paper, we give a study on the mobile diffusion source tracking in sensor networks. The CPA realtime localization method, the centroid realtime localization algorithm, the analytic realtime localization algorithm and the tracking method based on PF(Particle Filter) are presented to solve the mobile diffusion source tracking problem. The preconditions, advantages and deficiencies of the methods are given. The performances of different tracking methods are compared in simulations when node densities and sampling intervals are different. The results show that all the proposed methods are valid, while the tracking method based on PF is the most robust method compared to others.
Rapid circuit-specific inlining tuning for FPGA high-level synthesis

Assumptions about the underlying architecture of the target hardware is typically what dictates the behavior of compiler optimizations. Nevertheless, modern high-level synthesis (HLS) tools that target field-programmable gate arrays (FPGAs) are still using the same optimization passes that were developed and tuned for general purpose processors. This paper examines the effect of the inlining pass on HLS-generated hardware, focusing on the circuit area and clock cycles metrics. An iterative search method to create a custom inliner tailored to each benchmark for each specific metric is proposed and evaluated. The quality of the results generated is analyzed and the effect of the coefficients used for making the inline decisions are also separately investigated. Furthermore, a novel compiler cache is proposed, enabling the rapid evaluation of new inlining logic. Results show that a circuit-specific inliner is able to generate circuits with either 6% fewer LEs, 15% fewer clock cycles or 11% smaller LEs ∗ clock cycle product when compared to LLVM's default approach. Moreover, our inliner achieved a speedup of 23x when compared to LLVM performing the same task without the compiler cache.
Distributed network topology control for robotic swarm system: Abandonment approach

This paper proposes a distributed network topology control method for a robotic swarm system. The design concept of our method is that the agent preserve its communication links as possible, except cases the link preserving becomes a major restraint. A distributed model predictive consensus control method is proposed for the link preserving, and a link frustration value is defined to make a decision to stop the link preserving. Some computer simulation results show effects of the proposed method.
Effect of metformin on germ cell‐specific apoptosis, oxidative stress and epididymal sperm quality after testicular torsion/detorsion in rats

The study was designed to evaluate the effects of metformin on apoptosis and epididymal sperm quality in a rat testicular ischaemia/reperfusion (I/R) injury model. A total of 72 male rats were divided into four groups (n = 18 for each group): group 1 (sham‐operated group), group 2 (metformin group), group 3 (torsion/detorsion [T/D] + saline) and group 4 (T/D + 300 mg kg−1 metformin). Testicular torsion was achieved by rotating the right testis 720° in a clockwise direction for 1 hr. Tissue malondialdehyde (MDA) level and caspase‐3 activity increased and the activities of catalase, superoxide dismutase and glutathione peroxidase decreased in comparison with sham‐operated group 4 hr after detorsion (p < .001). In six rats of each group 24 hr after detorsion, histopathological changes and germ cell apoptosis were significantly deteriorated by measuring mean of seminiferous tubule diameters (MSTD) and TUNEL test. Moreover, 30 days after T/D, sperm concentration and motility were examined in six animals per group. Metformin pre‐treatment reduced MDA and caspase‐3 levels and normalised antioxidant enzyme activities 4 hr after detorsion, and germ cell apoptosis was significantly decreased, and the MSTD, as well as sperm functions, was significantly improved. Reduction in oxidative stress and apoptosis may have a major role in cytoprotective effects of metformin.
Optical Properties of Eu3+-Doped Y2O3 Nanotubes and Nanosheets Synthesized by Hydrothermal Method

Y<sub>2</sub>O<sub>3</sub>:Eu<sup>3+</sup> nanomaterials were obtained using a low-cost, large-scale, solution-based hydrothermal method followed by a thermal annealing process. The morphology of the Y<sub>2</sub>O<sub>3 </sub>:Eu<sup>3+</sup> nanomaterials can be controlled by tuning the aging time, aging temperature, and the pH values of the suspension. The optical properties of Y<sub>2</sub>O<sub>3</sub>:Eu<sup>3+</sup> nanosheets and nanotubes were investigated with the goal of improving the material's functionalities. Synchrotron X-ray diffraction patterns, field emission scanning electron microscopy images, high-resolution transmission electron microscopy images, emission spectra, excitation spectra, and fluorescence decay curves were measured and compared. The results showed that a novel Eu<sup>3+</sup> environment exists in Y<sub>2</sub>O<sub>3</sub>:Eu<sup>3+</sup> nanosheets, which led to rapid decay of emission at 611 nm. The unique properties of Y<sub>2</sub>O<sub>3</sub>:Eu<sup> 3+</sup> nanosheets could lead to potential applications in white light-emitting diodes (LEDs) based on GaAlN deep UV LEDs.
Analytical Calculation of Influence of Ferroelectric Properties on Electrical Characteristics Negative Capacitance Germanium FETs

Negative capacitance (NC) germanium (Ge) p-channel field effect transistors with different ferroelectric parameters are investigated by the analytical model. The channel surface potential amplification induced by the NC effect, which determines the subthreshold swing (SS) and the drain current <inline-formula> <tex-math notation="LaTeX">${I} _{\mathrm{ DS}}$ </tex-math></inline-formula> of the device, can be tuned by varying the thickness <inline-formula> <tex-math notation="LaTeX">${t} _{\mathrm{ fe}}$ </tex-math></inline-formula>, the coercive field <inline-formula> <tex-math notation="LaTeX">${E} _{c}$ </tex-math></inline-formula>, and the remnant polarization <inline-formula> <tex-math notation="LaTeX">${P} _{r}$ </tex-math></inline-formula> of the ferroelectric film. For the logic device, hysteresis phenomenon must be avoided, which is enabled by reducing <inline-formula> <tex-math notation="LaTeX">$t_{\mathrm{ fe}} $ </tex-math></inline-formula> or <inline-formula> <tex-math notation="LaTeX">$E_{c} $ </tex-math></inline-formula> of the ferroelectric film. Under the condition of <inline-formula> <tex-math notation="LaTeX">$t_{\mathrm{ fe}} =30$ </tex-math></inline-formula> nm, <inline-formula> <tex-math notation="LaTeX">$E_{c} =30$ </tex-math></inline-formula> KV/cm, and <inline-formula> <tex-math notation="LaTeX">$P_{r} =30\,\,\mu \text{C}$ </tex-math></inline-formula>/cm<sup>2</sup>, NC Ge transistors display the superior SS and <inline-formula> <tex-math notation="LaTeX">$I_{\mathrm{ DS}} $ </tex-math></inline-formula> compared to the baseline FETs.
Analyse de réseaux de régulation par approches de coloration de graphes dans le cadre du myélome multiple. (Regulatory networks analysis with graph coloring approaches applied to multiple myeloma)

Au cours des 2 dernieres decennies, l'explosion des capacites de production de donnees biologiques et des connaissances sur les interactions biologiques ont permis le developpement de nombreuses approches integrant des donnees avec des connaissances plus generales. Notre principal objectif etait de proposer de nouvelles methodes de caracterisation et de comparaison de profils d'expressions de genes issus de cellules cancereuses d'individus atteints de myelome multiple et de plasmocytes normaux. Pour cela, nous proposons 2 methodes basees sur les colorations de graphes de regulation. La premiere, qui permet d'inferer l'etat des proteines et des facteurs de transcription a partir d'un profil d'expression, nous a permis d'identifier des activites de facteurs de transcription impliques dans ces tumeurs. La seconde methode permet de diviser un reseau de regulation en plusieurs sous-graphes independant (des composants) vis a vis de colorations dites "parfaites". Via cette approche, nous avons pu evaluer la similarite entre les profils d'expression et les etats "parfait" des composants et en identifier specifiquement perturbes dans les cellules cancereuses associes a des voies oncogeniques.
Sedimentological processes and environmental variability at Lake Ohrid (Macedonia, Albania) between 637 ka and the present

Abstract. Lake Ohrid (Macedonia, Albania) is thought to be more than 1.2 million years old and host more than 300 endemic species. As a target of the International Continental scientific Drilling Program (ICDP), a successful deep drilling campaign was carried out within the scope of the Scientific Collaboration on Past Speciation Conditions in Lake Ohrid (SCOPSCO) project in 2013. Here, we present lithological, sedimentological, and (bio-)geochemical data from the upper 247.8 m composite depth of the overall 569 m long DEEP site sediment succession from the central part of the lake. According to an age model, which is based on 11 tephra layers (first-order tie points) and on tuning of bio-geochemical proxy data to orbital parameters (second-order tie points), the analyzed sediment sequence covers the last 637 kyr. The DEEP site sediment succession consists of hemipelagic sediments, which are interspersed by several tephra layers and infrequent, thin (
Daily rhythms are retained both in spontaneously developed sarcomas and in xenografts grown in immunocompromised SCID mice

The circadian clock generates and regulates many daily physiological, metabolic and behavioral rhythms as well as acute responses to various types of stresses including those induced by anticancer treatment. It has been proposed that modulatory function of the clock may be used for improving the therapeutic efficacy of established anti-cancer treatments. In order to rationally exploit this mechanism, more information is needed to fully characterize the functional status of the molecular clock in tumors of different cellular origin; however, the data describing tumor clocks are still inconsistent. Here we tested the status of clock in two models of tumors derived from connective tissue: sarcomas spontaneously developed in p53-deficient mice and human fibrosarcoma cells grown as xenografts in immunocompromised severe combined immunodeficient (SCID) mice. We show that both types of tumors retain a functional clock, which is synchronized in phase with normal tissues. We also show that spontaneously developed tumors are not only oscillating in the context of an organism where they receive hormonal and metabolic signals but continue oscillating ex vivo in tissue explants demonstrating that tumors have functional clocks capable of timing all their functions. We also provide evidence that similar to liver, tumors can be synchronized by food availability independent of the central pacemaker in the suprachiasmatic nuclei (SCN). These data provide the basis for the design of anticancer therapies that take into account the circadian metabolic and physiological patterns of both the tumor and normal tissues.
Engaging Alumni as Mentors for Nursing Students.

P eer mentoring among undergraduate nursing studentshasbeenreported, includingan integrative review of 11 studies evaluating research on peer mentorship. Mentoring graduate students in nursing also hasbeenstudied,ashas thementoringofnurse faculty. However, mentoring nursing students by alumni has not been widely studied. Two reports about a mentoring program using alumni as mentors were found in the literature. In 2001, researchers from a public university in Georgia matched at-risk nursing students (n = 24) with alumni of the school. Program goals included providing a more supportive educational climate, easing socialization into the profession,and improvinggraduationrates.Thisprogram was successful with 87.5% of the at-risk students (n = 21) finishing the semester; their successwas at least partially attributed to thementoring program. Another study specifically matching nursing students with nursing alumni was completed in Canada. Nursing alumni were matched with current nursing students. Over several years, 146nursing students participated in thementoring program. Through this process, the students reported that they benefitted from the emotional support provided by mentors and received educational support through clarification of course work and opportunities for other learning experiences. In addition, students indicated that they learned more about the nursing profession and the roles and responsibilities of nurses through interaction with theirmentor.Thealumnimentors reported feeling satisfied providing support for their mentee through sharing their knowledge and experience.
An evaluation of the reconstructed coefficient of determination and potential adjustments

ABSTRACT Previously, a method was proposed for calculating a reconstructed coefficient of determination in the case of right-censored regression using the expectation–maximization (EM) algorithm. This measure is assessed via simulation study for the purpose of evaluating the utility of model fit. Further, several reconstructed adjusted coefficients of determination are proposed and compared via simulation study for the purpose of model selection. The application of these proposed measures is illustrated on a real dataset.
Omega-3 Polyunsaturated Fatty Acids in Blood Pressure Control and Essential Hypertension

Hypertension is a worldwide problem that affects up to 22% of adults and contributes to the global burden of disability due to cardiovascular disease. Several factors influence blood pressure and participate to the development of hypertension. Among these factors, polyunsaturated fatty acids of the omega-3 family (omega-3 PUFA) are effective hypotensive agents. Through their anti-inflammatory and antioxidant properties, omega-3 PUFA can improve cardiac hemodynamics and vascular function and potentially reduce arterial stiffness and atherosclerotic damage. However, despite this promising evidence many meta-analyses on the cardiovascular effect of omega-3 PUFA were inconclusive. The choice of the omega-3 PUFA sources, baseline tissue content of these fatty acids, and individual compliance to their intake can be reasons for such a discrepancy between studies. Basic and clinical research on these fatty acids docu‐ ments interesting mechanisms through which these molecules could be useful in the treatment of hypertension and its related organ damage. The role of the maternal dietary habit during pregnancy and the quality of prenatal growth on the effect of omega-3 PUFA in cardiovascular system need further investigations. This chapter summarizes the literature of the past 30 years on the antihypertensive effects of this family of essential fatty acids.
Positive and Negative Label Propagations

This paper extends the state-of-the-art label propagation (LP) framework in the propagation of negative labels. More specifically, the state-of-the-art LP methods propagate information of the form “the sample <inline-formula> <tex-math notation="LaTeX">$i$ </tex-math></inline-formula> should be assigned the label <inline-formula> <tex-math notation="LaTeX">$k$ </tex-math></inline-formula>. ” The proposed method extends the state-of-the-art framework by considering additional information of the form “the sample <inline-formula> <tex-math notation="LaTeX">$i$ </tex-math></inline-formula> should not be assigned the label <inline-formula> <tex-math notation="LaTeX">$k$ </tex-math></inline-formula>. ” A theoretical analysis is presented in order to include negative LP in the problem formulation. Moreover, a method for selecting the negative labels in cases when they are not inherent from the data structure is presented. Furthermore, the incorporation of negative label information in two multigraph LP methods is presented. Finally, a discussion on the proposed algorithm extension to out of sample data, as well as scalability issues, is presented. Experimental results in various scenarios showed that the incorporation of negative label information increases, in all cases, the classification accuracy of the state of the art.
Power Efficient Secure Web Servers

The power consumption of web servers and associated se- curity devices is becoming an increasing issue both from an economic and environmental perspective. This paper analyses the power consumption of both security software and web server software and concludes that traditional architectures waste energy with repeated transitions up and down the TCP/IP stack. This contention is proved by comparing the energy usage of a traditional architec- ture and a new architecture whereby IDS functionality is moved into the web server and all operations share HTTP packets. Based on these ndings we propose a novel al- ternative power ecient architecture for web servers that may also be usable in other network systems.
The association between coeliac disease and periodontitis: Results from NHANES 2009–2012

AIM To investigate whether coeliac disease (CD) was associated with periodontitis among a nationally representative sample of US adults. MATERIALS AND METHODS The National Health and Nutrition Examination Survey (NHANES) 2009-2012 enrolled 6,661 subjects with full-mouth periodontal examination and serological testing for antitissue transglutaminase (tTg) and antiendomysial (EMA) antibodies. CD was defined as (i) self-reported physician diagnosis while on a gluten-free diet; or (ii) tTg levels >10.0 U/ml and positive EMA results. Positive serology without self-reported diagnosis was defined as undiagnosed CD (UdxCD). Periodontitis was defined according to the CDC/AAP definition. Multivariable linear and logistic models were used to regress the mean probing depth (PD) or attachment loss (AL) outcomes across CD categories (none, diagnosed and undiagnosed). RESULTS The prevalence of moderate/severe periodontitis and diagnosed/undiagnosed CD was 40% and 0.74%, respectively. Mean AL was lower among those with CD although results were not statistically significant (p = .67). The odds of periodontitis among individuals with diagnosed and undiagnosed CD were: 0.5(0.22, 1.16) and 0.62(0.1, 3.75), respectively. Mean PD levels among those without CD or with diagnosed or undiagnosed CD were 1.49 ± 0.02, 1.36 ± 0.11 and 1.31 ± 0.11 (p = .03). CONCLUSION CD is associated with modestly lower levels of mean PD but was not associated with mean AL or periodontitis. Larger studies are necessary to enhance precision and strengthen conclusions.