Miracle-dz/UniFAR-FTUs huggingface dataset:
Complete Sequence and Annotation of the Mycoplasma phocicerebrale Strain 1049T Genome

The Mycoplasma phocicerebrale genome was analyzed to better understand this opportunistic pathogen. Amplification with ϕ29 polymerase was used to generate enough genomic DNA for large-insert library construction. Like other mycoplasmas from seals, M. phocicerebrale encodes an immunosuppressor that may predispose susceptibility to infection or influence intercurrent diseases of affected hosts. ABSTRACT The Mycoplasma phocicerebrale genome was analyzed to better understand this opportunistic pathogen. Amplification with ϕ29 polymerase was used to generate enough genomic DNA for large-insert library construction. Like other mycoplasmas from seals, M. phocicerebrale encodes an immunosuppressor that may predispose susceptibility to infection or influence intercurrent diseases of affected hosts.
Performance evaluation of ESM deinterleaver using TOA analysis

A radar electronic support measures (ESM) system performs the functions of threat detection and area surveillance to determine the identity of surrounding emitters. ESM systems incorporate a passive receiver that measures the parameters of the detected radar pulses and a deinterleaver processor that sorts and segregates the received radar pulses into a number of radar cells depending on the mono-pulse parameters of the received pulses. These radar cells are submitted to the threat library of the EW system and compared with stored parameters of known radars to determine the identity of the estimated radar cell and take appropriate action against it. If there is no match with any radar in the threat library, the library is updated to include this new intercepted radar. However, if the deinterleaver does not work properly, false radars are generated. These false radars force the EW system to use military resources against false threats. This paper presents a method for evaluating the performance of the deinterleaving algorithms based on the TOA information inside the estimated radar cells. Thus, if some of the estimated radar cells achieve a certain confidence level, only these cells are submitted to the threat library. This method is useful in avoiding wasting limited resources, and can be applied to stable, jitter, and stagger PRI radars.
Assessing the Impact of Complementary and Alternative Medicine Trials in Oncology

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons AttributionNonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). Letter to the Editor
Investigating mind markers in design meetings

In the context of the European AMI1 project, “Augmented Multiparty Interaction” more than one hundred hours of video and audio data have been collected of groups of four people engaged in a meeting with the task to design a new remote control. The collection of meetings is being annotated on several layers, ranging from speech transcripts to emotion annotation. The main purpose of this data collection within the AMI project is to train, through machine learning techniques, automatic recognizers and interpreters of the data that would be able to deliver automatic meta-data which can be used in browsing and retrieval of new recordings. Besides this technological goal, the data collection will also be useful for the social sciences, particularly for the study of small group interactions.
Increased systemic and peritoneal oxidative stress biomarkers in endometriosis are not related to retrograde menstruation

ABSTRACT Objetives: The goal of this study was to determine if systemic and peritoneal oxidative stress biomarkers are related to each other and to retrograde menstruation in endometriosis. Methods: Plasma and peritoneal fluid oxidative stress biomarkers and hemoglobin and erythrocytes in peritoneal fluid as retrograde menstruation indicators, were measured in 28 patients with endometriosis and 23 without endometriosis. Results: In the peritoneal fluid, carbonyls and lipohydroperoxides, indicative of protein and lipid oxidative damage, were higher in endometriosis group (21%, p = 0.016 and 46%, p = 0.009, respectively). However, these biomarkers were not different in the blood plasma of both groups, and only protein dityrosine, was increased in the plasma of endometriosis group (31%, p = 0.04). The peritoneal fluid hemoglobin content was not higher in the endometriosis group, nor related to carbonyls and lipohydroperoxides. Additionally, the peritoneal fluid oxidative biomarkers were not correlated with the blood plasma ones, and only malondialdehyde, and ischemia-modified albumin were almost two times higher in peritoneal fluid. Discussion: Our results show a peritoneal and systemic oxidative stress biomarkers increase in endometriosis, but not related to each other, and do not support the hypothesis of an increase in hemoglobin-iron supply towards the peritoneal cavity that causes oxidative damage.
A Meta-Epidemiological Appraisal of the Effects of Interdisciplinary Multimodal Pain Therapy Dosing for Chronic Low Back Pain

Using a meta-analysis, meta-regression, and a meta-epidemiological approach, we conducted a systematic review to examine the influence of interdisciplinary multimodal pain therapy (IMPT) dosage on pain, disability, return to work, quality of life, depression, and anxiety in published randomised controlled trials (RCTs) in patients with non-specific chronic low back pain (CLBP). We considered all RCTs of IMPT from a Cochrane review and searched PubMed for additional RCTs through 30 September 2018. A subgroup random-effects meta-analysis by length, contact, and intensity of treatment was performed followed by a meta-regression analysis. Using random and fixed-effect models and a summary relative odds ratio (ROR), we compared the effect sizes (ES) from short-length, non-daily contact, and low-intensity RCTs with long-length, daily contact, and high-intensity RCTs. Heterogeneity was quantified with the I2 metric. A total of 47 RCTs were selected. Subgroup meta-analysis showed that there were larger ES for pain and disability in RCTs with long-length, non-daily contact, and low intensity of treatment. Larger ES were also observed for quality of life in RCTs with short-length, non-daily contact, and low intensity treatment. However, these findings were not confirmed by the meta-regression analysis. Likewise, the summary RORs were not significant, indicating that the length, contact, and intensity of treatment did not have an overall effect on the investigated outcomes. For the outcomes investigated here, IMPT dosage is not generally associated with better ES, and an optimal dosage was not determined.
State-of-the-Art: Research Theoretical Framework of Information Systems Implementation Research in the Health Sector in Sub-Saharan Africa

This study is about the state-of-the-art of reference theories and theoretical framework of information systems implementation research in the health industry in the Sub-Saharan countries from a process perspective. A process – variance framework, Poole et al, (2000), Markus & Robey, (1988) and Shaw & Jarvenpaa, (1997) is employed to examine reference theories employed in research conducted on information systems implementation in the health sector in the Sub-Saharan region and published between 2000 and 2013. Using a number of key words and searching on a number of databases, EBSCO, CSA, CINAHL, Science Direct and Emerald, we identified 41 published research articles that met our inclusion criteria. The articles were mapped unto the process-variance framework. A significant finding in this critical review is that, a large proportion of the studies were underpinned by variance or factor theories. While variance or factor models are useful and appropriate for the examination of static phenomenon, they are unsuitable for studying implementation, which is conceived as a dynamic and change phenomenon. There is therefore a need to increase research studies that employ the process theoretical framework to enhance our insight into successful information systems implementation in the region.
QSAR modeling, pharmacophore-based virtual screening, and ensemble docking insights into predicting potential epigallocatechin gallate (EGCG) analogs against epidermal growth factor receptor

Abstract Epigallocatechin gallate (EGCG) is a major polyphenols of green tea may have the possibility to inhibit epidermal growth factor receptor (EGFR) activity and lead to reduce non-small cell lung cancer (NSCLC) progression. However, EGCG has some toxic features; moreover, there is a lack of explorations into the molecular interaction mechanisms of EGCG and the EGFR. In this examination, integration of quantitative structure–activity relationship (QSAR) modeling, pharmacophore-based virtual screening, and ensemble docking approaches were used to predict potential novel EGCG analogs as effective EGFR inhibitors. QSAR modeling of logP and logS predictions and toxicity endpoint investigation for a set of 82 compounds were shown good predictive ability and robustness from the applicability domain and confusion matrix elucidations. Virtual screening and docking studies revealed that seven high potential EGCG analogs as strong EGFR binders. Molecular interactions interpretations indicated some insights into the structural features of ligands that efficiently interfere with mutation possible residues (Gly719 and Thr790) of the EGFR. The hydrogen bonds, hydrophobic interactions, atomic π-cation interactions and salt bridges of ligands are contributing additional stability to receptor structure, which can lead to blocking the intracellular protein-tyrosine kinase activity, including EGFR associated pathways activation in NSCLC. Therefore, this can characterize as a block-cluster mechanism between EGCG analogs and EGFR complexes. In silico anti-EGFR and anticancer activity predictions suggested that, ligands could act as promising pharmacological, anticancer, and drug-like templates of EGFR towards moderating the NSCLC progressions. These results and provided pinpoints could be beneficial to recognize probable therapeutic targets for NSCLC therapy.
Proceedings of the 13th annual ACM international conference on Mobile computing and networking

Welcome to ACM MobiCom 2007, the Thirteenth Annual International Conference on Mobile Computing and Networking, in Montreal, Canada. Continuing the tradition of one of the premier conferences in mobile networking, we have an exciting program on offer with papers, posters and panel, representing the best of today's research in mobile networking and computing! We received 233 paper submissions from 28 countries, out of which 26 papers were accepted as full papers and 14 papers were accepted as Extended Abstracts to be presented as posters. The quality of papers was outstanding as usual, forcing many hard choices on the Technical Program Committee (TPC). To select the papers, we employed a three-phase process. First, the TPC selected papers from an access-controlled web site and provided reviews; then, we had an online discussion phase that selected about 80 papers for more detailed discussion; finally, we had a TPC meeting in Evanston, Illinois to discuss and select 40 papers for inclusion in the program, either as full papers or Extended Abstracts. The review process was double blind and every paper received at least three reviews, many received four, and some received five reviews. As in previous years, we have a Best Student Paper Award. The selection of the best student paper was done in two stages. First, a TPC sub-committee consisting of Farooq Anjum, Suman Banerjee, Sneha Kasera, Ben Liang and Mehul Motani short-listed candidate papers from among all full papers whose primary author was a student. These papers were reviewed in more detail, and discussed, after which consensus was reached on the winning paper. The MobiCom '07 Best Student Paper award goes to "Crossing Over the Bounded Domain: From Exponential To Power-law Inter-meeting Time in MANET" by Han Cai and Do Young Eun from North Carolina State University. Our congratulations to the authors. Coming to the technical program, we have a wide variety of papers and posters organized into eight sessions over three days. These include poster presentations of Extended Abstracts as well as student posters and demonstrations that were selected using a separate process from the papers. One of the sessions is dedicated to Challenge papers that describe revolutionary new approaches, technologies or visions to stimulate new research directions. We hope that you will find the MobiCom '07 technical program helpful in your research.
Efficacy and safety with ticagrelor in patients with prior myocardial infarction in the approved European label: insights from PEGASUS-TIMI 54

Abstract Aims In PEGASUS-TIMI 54, ticagrelor significantly reduced the risk of the composite of major adverse cardiovascular (CV) events by 15–16% in stable patients with a prior myocardial infarction (MI) 1–3 years earlier. We report the efficacy and safety in the subpopulation recommended for treatment in the European (EU) label, i.e. treatment with 60 mg b.i. d. initiated up to 2 years from the MI, or within 1 year after stopping previous adenosine diphosphate receptor inhibitor treatment. Methods and results Of the 21 162 patients enrolled in PEGASUS-TIMI 54, 10 779 patients were included in the primary analysis for this study, randomized to ticagrelor 60 mg (n = 5388) or matching placebo (n = 5391). The cumulative proportions of patients with events at 36 months were calculated by the Kaplan–Meier (KM) method. The composite of CV death, MI, or stroke occurred less frequently in the ticagrelor group (7.9% KM rate vs. 9.6%), hazard ratio (HR) 0.80 [95% confidence interval (CI) 0.70–0.91; P = 0.001]. Ticagrelor also reduced the risk of all-cause mortality, HR 0.80 (0.67–0.96; P = 0.018). Thrombolysis in myocardial infarction major bleeding was more frequent in the ticagrelor group 2.5% vs. 1.1%; HR 2.36 (1.65–3.39; P < 0.001). The corresponding HR for fatal or intracranial bleeding was 1.17 (0.68–2.01; P = 0.58). Conclusion In PEGASUS-TIMI 54, treatment with ticagrelor 60 mg as recommended in the EU label, was associated with a relative risk reduction of 20% in CV death, MI, or stroke. Thrombolysis in myocardial infarction major bleeding was increased, but fatal or intracranial bleeding was similar to placebo. There appears to be a favourable benefit-risk ratio for long-term ticagrelor 60 mg in this population. Clinical trial registration http://www.clinicaltrials. gov NCT01225562
PetroSPIRE: a multimodal content-based retrieval system for petroleum applications

In this paper we present a novel content-based search application for petroleum exploration and production. The target application is specification of and search for geologically significant features to be extracted from 2D imagery acquired from oil well bores, in conjunction with 1D parameter traces. The PetroSPIRE system permits a user to define rock strata using image examples in conjunction with parameter constraints. Similarity retrieval is based multimodal search, an relies on texture-matching techniques using pre-extracted texture features, employing high- dimensional indexing and nearest neighbor search. Special- purpose visualization techniques allow a user to evalute object definitions, which can then be iteratively refined by supplying multiple positive and negative image examples as well as multiple parameter constraints. Higher-level semantic constructs can be created from simpler entities by specifying sets of inter-object constraints. A delta-lobe riverbed, for examples, might be specified as layer of siltstone which is above and within 10 feet of a layer of sandstone, with an intervening layer of shale. These 'compound objects', along with simple objects, from a library of searchable entities that can be used in an operational setting. Both object definition and search are accomplished using a web-based Java client, supporting image and parameter browsing, drag-and-drop query specification, and thumbnail viewing of query results. Initial results from this search engine have been deemed encouraging by oil- industry E and P researchers. A more ambitious pilot is underway to evaluate the efficacy of this approach on a large database from a North Sea drilling site.
Construction of an ICF core set and ICF-based questionnaire assessing activities and participation in patients with systemic sclerosis.

OBJECTIVES To develop an International Classification of Functioning, Disability and Health (ICF) core set for SSc and to conceive a patient-centred ICF-based questionnaire assessing activities and participation in patients with SSc. METHODS The construction of the ICF core set followed two steps. In the first step, meaningful concepts related to SSc were collected using data source triangulation from patients (n = 18), experts (n = 10) and literature (n = 174 articles). In the second step, concepts were linked to the best-matching ICF categories by one reviewer according to prespecified linking rules. Finally, patient-reported activities and participation categories of the ICF core set were translated into understandable questions. RESULTS After linking concepts to ICF categories, 150 ICF categories were collected from focus groups, 22 from experts and 82 from literature. After fusion of the sources and removal of duplicates, the ICF core set included 164 categories: one at the first level, 157 at the second level and six at the third level, with 50 categories on body functions, 15 on body structures, 52 on activities and participation, and 47 on environmental factors. Patient-reported ICF categories on activities and participation were translated into a patient-centred ICF-based 65-item questionnaire. CONCLUSION The present study proposes an ICF core set that offers a conceptual framework for SSc patients' care and health policy. Using a patient-centred approach, a patient-centred ICF-based questionnaire, the Cochin Scleroderma ICF-65 questionnaire, assessing activities and participation in patients with SSc, was conceived. TRIAL REGISTRATION ClinicalTrials.gov, http://clinicaltrials.gov, NCT01848418.
Establishment of a non-small-cell lung cancer-liver metastasis patient-derived tumor xenograft model for the evaluation of patient-tailored chemotherapy

In order to optimize patient-tailored chemotherapy, a non-small-cell lung cancer (NSCLC)-liver metastasis patient-derived tumor xenograft (PDTX) model is developed. Computed tomography (CT)-guided NSCLC percutaneous biopsy was subcutaneously inoculated into the flank of non-obese diabetic/severe combined immunodeficiency (NOD/SCID) female mice (PDTX F1) and allowed to reach 500 mm3 volume. Then, the tumors were re-transplanted into Balb/c nude mice and liver metastasis was confirmed (PDTX F2), which were further assigned into doxorubicin (DOX), docetaxel (DTX), and non-treatment control group. H&E staining and Keratin 20 (CK20) staining were applied to determine the consistency of PDTX models and primary tumors. Tumor growth curve, body weight, and the expression of p65 nuclear factor (NF)-κB and the secretion of interferon (IFN)-γ were investigated. The successive transplant procedure can induce the NSCLC-liver metastasis PDTX model, and morphological and structural characteristics of PDTX models (F2) were in accordance with primary tumors. DOX and DTX could delay tumor growth, activate the NF-κB pathway, and promote IFN-γ secretion in the PDTX models. The NSCLC-liver metastasis PDTX model is established and provides a powerful mean to assess chemotherapeutic efficacy.
Associations between placental CpG methylation of metastable epialleles and childhood body mass index across ages one, two and ten in the Extremely Low Gestational Age Newborns (ELGAN) cohort

ABSTRACT The Developmental Origins of Health and Disease (DOHaD) hypothesis posits that in utero and early life conditions can disrupt normal fetal development and program susceptibility to later-life disease. Metastable epialleles are genomic loci in which CpG methylation patterning is responsive to maternal diet and conserved across time and tissues. Thus, these sites could serve as ‘signatures’ of gestational environment conditions. Here, we sought to determine if methylation of metastable epialleles was associated with changes in childhood body mass index (BMI) z-scores across ages one, two and ten in the Extremely Low Gestational Age Newborns (ELGAN) cohort. CpG methylation of 250 probes (corresponding to 111 genes) within metastable epiallele regions was measured in placental tissue. Linear mixed effects models were fit to evaluate the overall and sex-stratified associations between methylation and changes in BMI z-score over time. In total, 26 probes were associated (p < 0.05) with changes in BMI z-score overall, including probes within Mesoderm Specific Transcript (MEST) and Histone Deacetylase 4 (HDAC4), which have previously been associated with childhood obesity and adipogenesis. Sex-stratified analyses revealed a significant association, after adjusting for multiple comparisons (q < 0.05), within female placentas for one probe annotated to the imprinted gene PLAG1 Like Zinc Finger 1 (PLAGL1). These findings suggest epigenetic marks may be involved in programming susceptibility to obesity in utero and highlight the potential to use placental tissues in predicting growth rate trajectories among premature infants.
Adaptive spatial filtering with data-dependent training for improved radar signal detection and localisation in structured interference

Adaptive spatial filtering is applied in modern surveillance radar systems to improve the detection and localisation of desired signals embedded in severe and dynamic interference from clutter as well as jamming. In practical situations of interest, the interference can only be cancelled to sufficiently low levels by significantly compromising the sidelobe response of the adapted pattern. Attempts to effectively stabilise the sidelobes, by means of diagonal loading or rank-reduction for example, gives rise to suboptimal patterns which potentially lead to intolerable degradations in interference suppression. On the other hand, the application of an adaptive pattern with unregularised sidelobes to a test cell containing a signal that is not incident from the system steer direction may cause an unwanted detection or false alarm. This paper proposes a data-dependent training strategy for adaptive spatial filters which provide enhanced interference rejection with a reduced likelihood of false alarms while simultaneously avoiding target self-nulling when the beam is pointed in the signal direction.
A multiple modulation synthesis method with high spatial resolution for noninvasive neurostimulation

Noninvasive neurostimulation plays a pivotal role in the direct control of neural circuits and the modulation of neuronal function. However, it is difficult to balance both spatial resolution and penetration depth when stimulating deep neurons. Here, we designed a multiple (time-division, frequency and polarity) modulation synthesis (MMS) method for noninvasively stimulating deep neurons with low-frequency envelopes. Compared to conventional transcranial electrical stimulation, we demonstrated that it can stimulate deep neurons at the desired firing rate (beat frequency) with higher spatial resolution via a computational model combining finite element analysis and Hodgkin-Huxley action potential model. Additionally, we measured the distribution of stimulus waveforms in saline solution to validate its effect. Taken together, the results of this study indicate that MMS stimulation with higher spatial resolution is steerable and might be a potential alternative to traditional implanted electrodes.