Miracle-dz/UniFAR-FTUs huggingface dataset:
THE EFFECTS OF NAVELBINE APPLICATION AS A SINGLE AGENT AND WITH TAMOXIFEN , EPIRUBICIN OR CARBOPLATIN ON GROWTH KINETICS OF FM 3 A CELLS

In this study, after investigation of cytotoxic effects of Navelbine on tumour derived cells, the most efficient drug or drug combinations were explored using Navelbine+Tamoxifen, Navelbine+Epirubicin and Navelbine+Carboplatin. FM3A cells derived from C3H mouse mammary carcinoma were used in this investigation. Growth rate, mitotic index, labelling index and as being cell kinetics parameters were evaluated in the experiments. Although Navelbine application on FM3A cell cultures was successful, Tamoxifen application showed better experimental results. Therefore Tamoxifen was indicated as decreasing cell kinetics parameters. If drugs were considered according to their effects on cultures, Epirubicin and Navelbine were also efficient respectively compared Tamoxifen application. Carboplatin application did not change growth kinetics of FM3A cells. When drug combinations were applied on FM3A cell cultures, Navelbine+Epirubicin combination on cell kinetics parameters was more effective than the others. Navelbine+Tamoxifenwas indicated as a second effective combination.
A weighted PSO based randomized step frequency radar with high resolution for compressed sensing

In this paper, a novel randomized step frequency radar with weighted PSO is proposed to recover the range and velocity joint estimating by exploiting sparseness of the targets and invoking compressed sensing (CS) theory. In this algorithm, we abandons the exhaustive list method in the Orthogonal Matching Pursuit (OMP) scheme, which is easy to cause performance degradation in the radar system. Instead, a weighted PSO dynamic optimal method is adopted, where the convergence speed is increased due to the weighted factor introduced in the Particle Swarm Optimization (PSO). The primary advantage of this method lies in being less sensitive to the initial value of target parameters in the case of online optimization process. Moreover, this method overcomes the limitation that the initial parameters must be selected close to the true value of the target, which is not constant in many cases. It is not necessary to know exactly the target parameters when using our approach, instead, coarse coding bounds of target parameters are enough for the algorithm, which can be done once and for all off-line, and it is only necessary to specify the initial scopes of the velocity and the range of the target. Simulation results demonstrate that the proposed weighted PSO approach provides a faster convergence speed and robustness against unpredictable perturbations for range and velocity joint estimating in randomized step frequency radar.
Dimensions of belief and feeling concerning three diseases, poliomyelitis, cancer, and mental illness: a factor analytic study.

The present study searches for regularities in the dimensions of beliefs and feelings for three major diseases. The data were derived from a probability sample of 436 adults who had indicated their perceptions concerning poliomyelitis, cancer, and mental illness on 16 modified semantic differential scales. For each disease these responses were factor analyzed and rotated to produce an orthogonal varimax solution. Factors labeled Personal Involvement, Human Mastery, and Social Acceptability emerged repeatedly. Similarities and differences among the factor solutions obtained for the diseases studied are discussed along with their limitations and implications.
Staff views on how to improve mealtimes for elderly people with dementia living at home

Dementia commonly leads to difficulties in performing daily activities, which can also often affect the ability to prepare and eat meals. As a result, formal support to maintain good nutritional intake might be needed, but there is a lack of knowledge concerning how to support older persons with dementia living at home. The aim of this study was to explore and describe staff views on how to improve mealtimes for persons with dementia who are still living at home. A qualitative descriptive study was performed and data were collected during 2011–2012 through four focus group interviews with staff working in the homes of persons with dementia. Data were analyzed using inductive content analysis. The participants described several ways to improve mealtimes for persons with dementia and advocated adjustments facilitating the preservation of the persons’ independence. Finding suitable actions calls for knowledge about the person and his/her individual situation. Proposed actions were enabling meals at home, taking over, and moving meals outside of the home. In addition, it was found that, the types of meals served to these persons should be as familiar to the individual as possible. The results of this study indicate the importance of using a person-centered approach and meeting the individual needs when supporting people with dementia in regards to their meals when living at home. Individualized care in the home may be expensive, however, it is fair to say that people who become malnourished and admitted to hospitals is even more costly. Furthermore, sharing and reflecting experiences and knowledge can assist staff to identify ways to manage complex situations. Therefore, the use of refection should be a part of staff members’ everyday work.
Bioavailability and pharmacokinetics of oral and injectable formulations of methadone after intravenous, oral, and intragastric administration in horses.

OBJECTIVE To characterize the bioavailability and pharmacokinetics of oral and injectable formulations of methadone after IV, oral, and intragastric administration in horses. ANIMALS 6 healthy adult horses. PROCEDURES Horses received single doses (each 0.15 mg/kg) of an oral formulation of methadone hydrochloride orally or intragastrically or an injectable formulation of the drug orally, intragastrically, or IV (5 experimental treatments/horse; 2-week washout period between each experimental treatment). A blood sample was collected from each horse before and at predetermined time points over a 360-minute period after each administration of the drug to determine serum drug concentration by use of gas chromatography-mass spectrometry analysis and to estimate pharmacokinetic parameters by use of a noncompartmental model. Horses were monitored for adverse effects. RESULTS In treated horses, serum methadone concentrations were equivalent to or higher than the effective concentration range reported for humans, without induction of adverse effects. Oral pharmacokinetics in horses included a short half-life (approx 1 hour), high total body clearance corrected for bioavailability (5 to 8 mL/min/kg), and small apparent volume of distribution corrected for bioavailability (0.6 to 0.9 L/kg). The bioavailability of methadone administered orally was approximately 3 times that associated with intragastric administration. CONCLUSIONS AND CLINICAL RELEVANCE Absorption of methadone in the small intestine in horses appeared to be limited owing to the low bioavailability after intragastric administration. Better understanding of drug disposition, including absorption, could lead to a more appropriate choice of administration route that would enhance analgesia and minimize adverse effects in horses.
Tacit Knowledge Transfer within Organisations

Knowledge and management of such knowledge have been studied for some time now as it became clear that a company with an unstructured approach to corporate knowledge management was incapable of competing in this new environment. As such, management of intangible assets, such as knowledge, came to be perceived as an important tool for competition. Based on that, this article aims to identify the pertinent factors for tacit knowledge transfer within a major government-controlled publicly-listed Brazilian oil company, namely Petrobras, by using a quantitative approach based on exploratory factorial analysis. It is concluded that idiosyncratic factors, the knowledge management strategy adopted by the company, and its organisational structure are relevant elements for the success of tacit knowledge transfer within the organisation. Hence, three propositions arising from the results obtained are consolidated and presented in order that they may be tested in a future explanatory study.
The relationships between perioperative CEA, CA 19‐9, and CA 72‐4 and recurrence in gastric cancer patients after curative radical gastrectomy

The correlation between perioperative CEA, CA 19‐9, and CA 72‐4 and recurrence of gastric cancer has not been clarified. The aim of this study was to investigate the relationships between perioperative CEA, CA 19‐9, and CA 72‐4 and recurrence of gastric cancer.
Diagnostic frozen prostate sextant biopsies: An approach for preserving protein and RNA for additional studies

Primary prostate cancer represents 29% of newly diagnosed visceral cancers in men. Despite this common occurrence, relatively little is known about the pathogenesis of this malignancy. High‐grade prostatic intraepithelial neoplasia (HGPIN) is generally accepted as a precursor to invasive prostate carcinoma. There is a lack of adequate animal models, and the available cell culture lines are limited. Tissue from prostate needle core biopsies that have been frozen can provide adequate material for both diagnosis and research.
Protective effect of Syzygium cuminii (Linn.) Skeels seed extract on lipid peroxidation in alloxan induced diabetic rats

The effect of Black plum, Syzygium cuminii (Linn.) Skeels (syn. S. jambolanum DC.) seed extract on lipid peroxidation in alloxan induced diabetic rats was studied. Alloxan 150mg (mg/kg body weight) increased significantly the glucose level in blood and induced the Lipid Peroxidation (LPO) in liver. The antioxidant enzymes Catalase (CAT), Reduced Glutathione (GSH), Glutathione peroxidase (GPx), Superoxide dismutase (SOD) in liver were decreased. Oral administration of the extract for 15 days to alloxan treated animals showed remarkable increase in the level of antioxidant enzymes and reduced the level of lipid peroxidation activity and blood glucose. The results suggest that seed extract of the plant is an antioxidant and acute hyperglycaemic drug and might be used in the regulation of lipid peroxidation without detectable adverse side effects.
A Preliminary Analysis of Software Engineering Metrics-based Criteria for the Evaluation of Learning Objects Reusability

Reusability of learning objects is evaluated on the basis of a priori software reusability analysis, which are related to cohesion and coupling aspects. A number of reusability metrics extracted from metadata records are defined and analyzed to provide an aggregate reusability evaluation for learning objects in a repository. The evaluation is validated and compared with an expert-based a posteriori evaluation method
Intracellular signaling during skeletal muscle atrophy

A variety of conditions lead to skeletal muscle atrophy including muscle inactivity or disuse, multiple disease states (i.e., cachexia), fasting, and age‐associated atrophy (sarcopenia). Given the impact on mobility in the latter conditions, inactivity could contribute in a secondary manner to muscle atrophy. Because different events initiate atrophy in these different conditions, it seems that the regulation of protein loss may be unique in each case. In fact differences exist between the regulation of the various atrophy conditions, especially sarcopenia, as evidenced in part by comparisons of transcriptional profiles as well as by the unique triggering molecules found in each case. By contrast, recent studies have shown that many of the intracellular signaling molecules and target genes are similar, particularly among the atrophies related to inactivity and cachexia. This review focuses on the most recent findings related to intracellular signaling during muscle atrophy. Key findings are discussed that relate to signaling involving muscle ubiquitin ligases, the IGF/PI3K/Akt pathway, FOXO activity, caspase‐3 activity, and NF‐kappaB signaling, and an attempt is made to construct a unifying picture of how these data can be connected to better understand atrophy. Once more detailed cellular mechanisms of the atrophy process are understood, more specific interventions can be designed for the attenuation of protein loss. Muscle Nerve, 2006
Dissection of the mouse N-ras gene upstream regulatory sequences and identification of the promoter and a negative regulatory element

The 5' flanking region of the mouse N-ras gene was investigated to determine the elements governing transcriptional activity of the gene. The promoter did not contain typical TATA or CCAAT boxes, and according to primer extension and RNase protection analyses, transcription started at several sites. These assays also confirmed the short nucleotide distance interposed between the N-ras transcription unit and the previously described upstream unr gene. Chromatin studies performed by digestion of nuclei with DNase I revealed the presence of four hypersensitive sites: a, b, c, and d. Deletion mutagenesis of the 5' flanking region revealed sequences responsible for both promotion and inhibition of transcription. These sequences resided within 230 bp upstream of the transcription initiation site. Hypersensitive site b colocalized with the 76-bp segment with promoter activity. The negative regulatory element at position -180 colocalized with hypersensitive site a, was active on the N-ras promoter in stable as well as transient assays, and down-regulated the heterologous herpes simplex virus thymidine kinase promoter. Footprint analysis and in vivo transfection-competition experiments indicated that a trans-acting factor is responsible for the negative effect on transcription. The interaction between the cis-acting negative regulatory element and the promoter region may play a role in the tissue- and developmental-stage-specific patterns of expression of the N-ras gene.
2, 2′‐Dihydroxybenzophenones and Derivatives. Efficient Synthesis and Structure Endoscopy by DFT and NMR. Credentials as Potent Antiinflammatory Agents.

2,2’-dihydroxybenzophenones and derivatives have been synthesized directly or by oxidation of their incipiently obtained benzylic alcohols by diverse efficient methods. Oxime and N-acyl hydrazone derivatives have also been prepared. Their structure profile has been scrutinized by DFT/B3LYP-6-311++G** methodology, NMR spectroscopy and dihedral angle grid scan analysis. Energetically favorable conformations pointed to (i) an almost coplanar bifurcated 6-membered H bridge in ketones, (ii) a single 6-membered H bridge, accompanied by a 7-membered H bonding interaction in oximes and (iii) a single 6-membered H-bridge in hydrazones. In the latter case, a stable conformation with an additional 9-membered pseudo ring was also found. Highly deshielded protons in the NMR spectra are in accordance with the theoretically obtained findings on the H-bonded conformers. Significant anti-inflammatory activity of the compounds has been found by in vivo tests with their oxime and hydrazone derivatives showing the highest activity, hydrazone 11, in partucular, competing with marketed drugs. In silico docking studies point to the perspective potency of these structures as COX-1/COX-2 inhibitors.
Perception of Parental Acceptance in Women With Binge Eating Disorder

Abstract The authors contribute to the validating literature for binge eating disorder (BED) by examining perceptions of parents and satisfaction with life among obese women with and without BED. Participants were female patients, recruited through a private medical clinic, who were assigned to groups on the basis of body mass index (BMI) and scores on the Questionnaire on Eating and Weight Patterns (QEWP; R. L. Spitzer et al., 1992). Groups consisted of (a) obese women with BED (n = 32), (b) obese women who had no eating disorders (n = 51), and (c) nonobese women with no eating disorders (n = 30). All participants completed the Parental Acceptance/Rejection Questionnaire (PARQ; R. P. Rohner, 1986), the Satisfaction with Life Scale (SWLS; J. Fischer & K. Corcoran, 1994), and the Beck Depression Inventory (BDI; A. T. Beck & R. A. Steer, 1987). Obese women with BED perceived their fathers as more rejecting than did women in the other groups. Moreover, obese women with BED perceived their fathers as significantly more rejecting than their mothers. The BED group indicated lower satisfaction with life and higher levels of depression than the groups without eating disorders. These findings further validate the diagnostic category of BED. Obese women with BED appear to be a distinct subgroup of the obese population. The results indicate a need for further assessment of the father–daughter relationship in connection to BED and other eating disorders.
Randomised, double-blind, placebocontrolled parallel group study of P54FP for the treatment of dogs with osteoarthritis

P54FP is an extract of Indian and Javanese turmeric, Curcuma domestica and Curcuma xanthorrhiza respectively, which contains a mixture of active ingredients including curcuminoids and essential oils. A randomised, double-blind, placebo-controlled, parallel group clinical trial of P54FP as a treatment for osteoarthritis of the canine elbow or hip was conducted to assess its efficacy and safety. Sixty-one client-owned dogs with osteoarthritis were recruited through first-opinion practices and examined at a single centre. After a two-week wash-out period, they were randomly allocated to receive P54FP or a placebo orally twice daily for eight weeks, and were re-examined after four, six and eight weeks of treatment. The effectiveness of the treatment was assessed in terms of the peak vertical force (PVz) and vertical impulse of the affected limbs, as measured with a force platform, by clinical assessments of lameness and joint pain by the investigators, and overall assessments of the response to treatment by the investigators and the owners. The results from 25 P54FP-treated dogs and 29 placebo-treated dogs showed that there was no statistically significant difference between the groups in terms of the Pvz of the affected limb. The investigators' overall assessment showed a statistically significant treatment effect in favour of P54FP (P=0.012), but the owners' assessment just failed to reach statistical significance (P=0.063). No serious adverse effects were recorded, but two P54FP-treated dogs and four placebo-treated dogs were withdrawn from the study because their condition deteriorated.
Nasopharyngeal carcinoma–susceptibility locus is localized to a 132 kb segment containing HLA‐A using high‐resolution microsatellite mapping

Nasopharyngeal carcinoma (NPC) is an epithelial tumor uniquely prevalent in southern Chinese. HLA‐A2 is associated with NPC. In a previous study, we showed that the genes associated with susceptibility to NPC are primarily located within the HLA‐A locus in Taiwanese NPC patients. However, the pathogenic genes causing NPC susceptibility remain unknown. Here, 8 polymorphic microsatellite markers distributed over a 1 megabase region surrounding the HLA‐A locus were subjected to genetic analysis for the NPC‐susceptibility locus. Statistical studies of associated alleles detected on each microsatellite locus showed that the NPC‐ susceptibility genes are most likely located between the D6S510 and D6S211 markers within a 132 kb segment containing the HLA‐A locus. These results undoubtedly would facilitate the further positional cloning of the NPC‐susceptibility locus, which has been elusive for the past 30 years. © 2005 Wiley‐Liss, Inc.
Advanced Random Subspace Method(ARSM) for Accurate Cancer Classification

Recently, there have been significant research efforts to select identifiable gene markers between different phenotypes for diagnosing the disease class. However, discovering the reliable gene markers is a challenging problem. One of the weaknesses of existing gene expression based classification is that gene markers are often selected independently, although their functional products may interact with each other. And also, inherent measurement noise in the gene expression profile and the heterogeneity between samples make the problem more difficult. Recently, in order to overcome these weaknesses, several groups have alleviated this problem by jointly analyzing the expression levels of groups of functionally related genes based on pathway information. However, there is still remaining problems such as lower classification performance caused by the curse of dimensionality and potential information lose caused by ranking-based approach. In this paper, to overcome these problems, we propose a novel method based on combining pathway information and gene expression data using the random subspace method. We apply our proposed method to the classification of lung cancer data and show that it can outperformes several existing pathway based methods.
Substrate integrated waveguide diplexer with dual-mode junction cavity

A compact inline K-band diplexer with dual-mode junction cavity in substrate integrated waveguide (SIW) technology is presented. The dual-mode cavity provides a transition between the input port and the two channels of the diplexer, as well as one pole for each channel filter which results in a reduced size compared to other inline diplexer topologies. The diplexer design is carried out using an efficient mode-matching technique (MMT), and its performance is validated by simulated and measured results. The diplexer channels are located at 23.7 GHz and 25.7 GHz, with 5.9 and 5.4 percent fractional bandwidths, respectively. Inband return loss measurements are better than 17.43 dB and 17.24 dB, and the insertion losses are 1.64 dB and 2.2 dB, in the lower and higher bands, respectively.
Design of double U-slot microstrip patch antenna array for WiMAX

In this paper, a double U-slot microstrip patch antenna array for Worldwide interoperability for microwave access (WiMAX) is presented. The uniqueness of this design is that a double U-slot patch is designed on a single substrate with single feed. Antenna array is developed to increase the gain. The design is based on transmission line model. The radiation performance such as VSWR, return loss, radiation pattern and gain of the antenna are simulated using Ansoft HFSS and presented. A prototype antenna model is fabricated and tested using Network Analyzer. Measured results of VSWR and return loss are presented and discussed.
An Integrated Spatial Clustering Analysis Method for Identifying Urban Fire Risk Locations in a Network-Constrained Environment: A Case Study in Nanjing, China

The spatial distribution of urban geographical events is largely constrained by the road network, and research on spatial clusters of fire accidents at the city level plays a crucial role in emergency rescue and urban planning. For example, by knowing where and when fire accidents usually occur, fire enforcement can conduct more efficient aid measures and planning department can work out more reasonable layout optimization of fire stations. This article proposed an integrated method by combining weighted network-constrained kernel density estimation (NKDE) and network-constrained local Moran’s I (ILINCS) to detect spatial cluster pattern and identify higher-risk locations of fire accidents. The proposed NKDE-ILINCS weighted a set of crucial non-spatial attributes of point events and links, and considered the impact factors of road traffic states, intersection roads and fire severity in NKDE to reflect real urban environment. This method was tested using the fire data in 2015 in Nanjing, China. The results demonstrated that the method was appropriate to detect network-constrained fire cluster patterns and identify high–high road segments. Besides, the first 14 higher-risk road segments in Nanjing are listed. These findings of this case study enhance our knowledge to more accurately observe where fire accidents usually occur and provide a reference for fire departments to improve emergency rescue effectiveness.