Miracle-dz/UniFAR-FTUs huggingface dataset:
Building from the Bottom Up: A Closer Look into the Teaching and Learning of Life’s Principles in Biomimicry Design Thinking Courses

Biomimicry education is grounded in a set of natural design principles common to every known lifeform on Earth. These Life’s Principles (LPs) (cc Biomimicry 3.8), provide guidelines for emulating sustainable strategies that are field-tested over nearly four billion years of evolution. This study evaluates an exercise for teaching LPs to interdisciplinary students at three universities, Arizona State University (ASU) in Phoenix, Arizona (USA), College of Charleston (CofC) in Charleston, South Carolina (USA) and The Hague University of Applied Sciences (THUAS) in The Hague (The Netherlands) during the spring 2021 semester. Students researched examples of both biological organisms and human designs exhibiting the LPs. We gauged the effectiveness of the exercise through a common rubric and a survey to discover ways to improve instruction and student understanding. Increased student success was found to be directly linked to introducing the LPs with illustrative examples, assigning an active search for examples as part of the exercise, and utilizing direct assessment feedback loops. Requiring students to highlight the specific terms of the LP sub-principles in each example is a suggested improvement to the instructions and rubric. An iterative, face-to-face, discussion-based teaching and learning approach helps overcome minor misunderstandings. Reiterating the LPs throughout the semester with opportunities for application will highlight the potential for incorporating LPs into students’ future sustainable design process.
Dual-Band Aperture-Shared Fabry–Perot Cavity-Integrated Patch Antenna for Millimeter-Wave/Sub-6 GHz Communication Applications

This letter presents a dual-band antenna with a large frequency ratio of 11.7 (2.4 GHz/28 GHz) by integrating an mm-wave Fabry–Perot cavity (FPC) antenna into a sub-6 GHz patch antenna. The patch with periodic slots functions as both the 2.4 GHz radiator and the partially reflective surface (PRS) of the 28 GHz FPC antenna. By properly tuning the length of the periodic slot, the PRS's reflection can be easily adjusted. As the periodic slot's length and width operating at 28 GHz are much smaller than the wavelength at 2.4 GHz, periodic slot operating at 28 GHz have little impact on the radiation of the patch. Furthermore, because of the Fabry–Perot resonance, the antenna can have a peak gain reaching 15 dBi at 28 GHz band with an easy feeding structure. For demonstration, a prototype is fabricated and experimentally verified. Note that the frequency ratio is not limited to the proposed design (11.7 for demonstration). It can be easily adjusted based on the same principle.
First Detection of Methanogens in Orthopedic Prosthesis Infection: A Four-Case Founding Series

Orthopedic prosthesis infection must be medically managed after appropriate microbiological documentation. While bacteria and fungi are acknowledged to be causative opportunistic pathogens in this situation, the potential role of methanogens in orthopedic prosthesis infections is still unknown. In a retrospective study, a total of 100 joint and bone samples collected from 25 patients were screened by specific PCR assays for the detection of methanogens. PCR-positive samples were observed by autofluorescence, electron microscopy and tentatively cultured under specific culture conditions. Methanogens were detected by quantitative PCR in 4/100 samples, in the presence of negative controls. Sequencing identified Methanobrevibacter oralis in two cases, Methanobrevibacter smithii in one case and Methanobrevibacter wolinii in one case. Microscopic methods confirmed molecular findings and bacterial culture yielded two strains of Staphylococcus aureus, one strain of Staphylococcus epidermidis and one strain of Proteus mirabilis. These unprecedented data highlight the presence of methanogens in joint and bone samples of patients also diagnosed with bacterial orthopedic prosthesis infection, questioning the role of methanogens as additional opportunistic co-pathogens in this situation.
Evaluación del desempeño de sistemas de ventilación en salones de clase: Estudio numérico en edificios universitarios en Panamá

La calidad del aire juega un papel decisivo en el rendimiento de los ocupantes de espacios interiores; además, se estima que un 30% de la vida de una persona corresponde a su formación académica. El objetivo de esta investigación fue determinar si los sistemas de ventilación de los edificios de la Universidad Tecnológica de Panamá proveen una calidad de aire apropiada para sus alumnos, mediante la evaluación del desempeño de la ventilación en modo pasivo y mecánico; se utilizó la interfaz dinámica DesignBuilder para simular los casos de estudio. Los indicadores utilizados fueron la concentración de CO2, las tasas de renovación de aire interior y el confort térmico. Para esto se tomaron como referencia los requerimientos mínimos de la normativa panameña y normativas internacionales. Los resultados demostraron que el uso de ventilación natural resulta insuficiente debido a la inconformidad térmica y altas concentraciones de CO2. Por el contrario, el uso de ventilación mecánica mejoró los niveles de confort térmico pero la concentración de CO2 se mantuvo ligeramente fuera de límites aceptables. Estos resultados demostraron que los edificios no están diseñados para operar en modo pasivo, lo que restringe su operación exclusivamente en modo mecánico.
A Review on Recent Progress in the Integrated Green Hydrogen Production Processes

The thermochemical water-splitting method is a promising technology for efficiently converting renewable thermal energy sources into green hydrogen. This technique is primarily based on recirculating an active material, capable of experiencing multiple reduction-oxidation (redox) steps through an integrated cycle to convert water into separate streams of hydrogen and oxygen. The thermochemical cycles are divided into two main categories according to their operating temperatures, namely low-temperature cycles (<1100 °C) and high-temperature cycles (<1100 °C). The copper chlorine cycle offers relatively higher efficiency and lower costs for hydrogen production among the low-temperature processes. In contrast, the zinc oxide and ferrite cycles show great potential for developing large-scale high-temperature cycles. Although, several challenges, such as energy storage capacity, durability, cost-effectiveness, etc., should be addressed before scaling up these technologies into commercial plants for hydrogen production. This review critically examines various aspects of the most promising thermochemical water-splitting cycles, with a particular focus on their capabilities to produce green hydrogen with high performance, redox pairs stability, and the technology maturity and readiness for commercial use.
Bearing Deformation of Heavy-duty CNC Machine Tools & Foundation System

To study the effects of the heavy-duty gantry CNC machine tools concrete foundation on whole machine stiffness,this paper first proposed a constitutive model of reinforced composite foundation that could calculate space mesh reinforcement, establish transversely isotropic concrete foundation by boundary element equations,establish whole structure model based on finite element method,and thus complete establishing an upper and lower structure finite element-boundary element coupling model.Through practical examples,experiment of fiber Bragg grating method got the each component distribution points strain values, on the double integral of curvature at the distribution point determined part deformation curve. Meanwhile,deformation simulation analysis was carried out under the action of load,and the validity of the theoretical model was verified. Finally,bearing deformation of foundation of different reinforcement layers was studied,and some suggestions were obtained based on this theoretical model. The results provide a basis for the construction of the foundations of a heavy-duty machine tool and the selection of an optimization scheme thereof.
A Wearable Multimodal Sensing System for Tracking Changes in Pulmonary Fluid Status, Lung Sounds, and Respiratory Markers

Heart failure (HF) exacerbations, characterized by pulmonary congestion and breathlessness, require frequent hospitalizations, often resulting in poor outcomes. Current methods for tracking lung fluid and respiratory distress are unable to produce continuous, holistic measures of cardiopulmonary health. We present a multimodal sensing system that captures bioimpedance spectroscopy (BIS), multi-channel lung sounds from four contact microphones, multi-frequency impedance pneumography (IP), temperature, and kinematics to track changes in cardiopulmonary status. We first validated the system on healthy subjects (n = 10) and then conducted a feasibility study on patients (n = 14) with HF in clinical settings. Three measurements were taken throughout the course of hospitalization, and parameters relevant to lung fluid status—the ratio of the resistances at 5 kHz to those at 150 kHz (K)—and respiratory timings (e.g., respiratory rate) were extracted. We found a statistically significant increase in K (p < 0.05) from admission to discharge and observed respiratory timings in physiologically plausible ranges. The IP-derived respiratory signals and lung sounds were sensitive enough to detect abnormal respiratory patterns (Cheyne–Stokes) and inspiratory crackles from patient recordings, respectively. We demonstrated that the proposed system is suitable for detecting changes in pulmonary fluid status and capturing high-quality respiratory signals and lung sounds in a clinical setting.
Investigation of Resonant Activation in a Josephson Junction for Axion Search With Microwave Single Photon Detection

A growing interest in the detection of single microwave-photons has been stimulated by the search for light dark matter, such as Axions and Axion-like particles, together with the fast development of quantum technologies based on superconducting devices. Many solutions have been proposed in literature but most of them still fail to satisfy the tight requirements imposed by Dark Matter experiments. For instance, many have a large dark-count rate that still make parametric amplifiers a preferable choice. On the contrary, a device based on a current biased Josephson junction resonantly activated by the absorption of a microwave photon may have dark-counts rate down to the mHz level. Here, we report the experimental study of the resonant activation of an Al Josephson junction excited by continuous radiofrequency. The device under study consists of a chip with a transmission line terminated by an Al Josephson-junction, fabricated by shadow-mask evaporation technique. The sample-holder with the chip inside is hosted in a superconducting box and it is thermally anchored to the mixing-chamber plate of a dilution refrigerator at a temperature of about 15 mK. We measured the escape rates of the junction in different configurations of current bias and radiofrequency excitations. Response to continuous wave has been measured and interpreted within the RCSJ model. These results are used to optimize the design of a single microwave-photon detector.
High-throughput cryo-EM structure determination of amyloids

The formation of amyloid filaments is characteristic of various degenerative diseases. Recent breakthroughs in electron cryo-microscopy (cryo-EM) have led to atomic structure determination of multiple amyloid filaments, both of filaments assembled in vitro from recombinant proteins, and of filaments extracted from diseased tissue. These observations revealed that a single protein may adopt multiple different amyloid folds, and that in vitro assembly does not necessarily lead to the same filaments as those observed in disease. In order to develop relevant model systems for disease, and ultimately to better understand the molecular mechanisms of disease, it will be important to determine which factors determine the formation of distinct amyloid folds. High-throughput cryo-EM, in which structure determination becomes a tool rather than a project in itself, will facilitate the screening of large numbers of in vitro assembly conditions. To this end, we describe a new filament picking algorithm based on the Topaz approach, and we outline image processing strategies in Relion that enable atomic structure determination of amyloids within days.
Identification of a Negative Regulator for Salt Tolerance at Seedling Stage via a Genome-Wide Association Study of Thai Rice Populations

Salt stress is a major limiting factor in crop production and yield in many regions of the world. The objective of this study was to identify the genes responsible for salt tolerance in Thai rice populations. We performed a genome-wide association study with growth traits, relative water content, and cell membrane stability at the seedling stage, and predicted 25 putative genes. Eleven of them were located within previously reported salt-tolerant QTLs (ST-QTLs). OsCRN, located outside the ST-QTLs, was selected for gene characterization using the Arabidopsis mutant line with T-DNA insertion in the orthologous gene. Mutations in the AtCRN gene led to the enhancement of salt tolerance by increasing the ability to maintain photosynthetic pigment content and relative water content, while the complemented lines with ectopic expression of OsCRN showed more susceptibility to salt stress detected by photosynthesis performance. Moreover, the salt-tolerant rice varieties showed lower expression of this gene than the susceptible rice varieties under salt stress conditions. The study concludes that by acting as a negative regulator, OsCRN plays an important role in salt tolerance in rice.
Investigating the Broad Matrix-Gate Network in the Mitochondrial ADP/ATP Carrier through Molecular Dynamics Simulations

The mitochondrial ADP/ATP carrier (AAC) exports ATP and imports ADP through alternating between cytosol-open (c-) and matrix-open (m-) states. The salt bridge networks near the matrix side (m-gate) and cytosol side (c-gate) are thought to be crucial for state transitions, yet our knowledge on these networks is still limited. In the current work, we focus on more conserved m-gate network in the c-state AAC. All-atom molecular dynamics (MD) simulations on a variety of mutants and the CATR-AAC complex have revealed that: (1) without involvement of other positive residues, the charged residues from the three Px[DE]xx[KR] motifs only are prone to form symmetrical inter-helical network; (2) R235 plays a determinant role for the asymmetry in m-gate network of AAC; (3) R235 significantly strengthens the interactions between H3 and H5; (4) R79 exhibits more significant impact on m-gate than R279; (5) CATR promotes symmetry in m-gate mainly through separating R234 from D231 and fixing R79; (6) vulnerability of the H2-H3 interface near matrix side could be functionally important. Our results provide new insights into the highly conserved yet variable m-gate network in the big mitochondrial carrier family.
The Individual and Combined Effect of Nanoparticles and Biofertilizers on Growth, Yield, and Biochemical Attributes of Peanuts (Arachis hypogea L.)

A two-year (2020–2021) field experiment was conducted to investigate the impact of particular nanoparticles and biofertilizers on the growth, yield, and biochemical attributes of peanuts (Cv. Giza 6). Before planting, the seeds were inoculated with two biofertilizers, mycorrhiza and phosphorine, and were considered the main plot. The subplot contained foliar sprays of nanoparticles, i.e., 200 ppm boron (B), 200 ppm calcium (Ca), their combination (Ca+B), and the control (no spray). The results revealed that mycorrhiza significantly increased 100-seed weight (70.45 g), seed yield (1.9 ton/ha), biological yield (7.5 ton/ha), crop growth rate (CGR) (2.9 g day−1 m−2), branching number (12.5), and protein content (22.96) compared with the control or phosphorine. Among the nanoparticles, Ca+B maximally improved plant height, CGR, 100-seed weight, shelling percentage, seed yield, oil content, and seed protein, while plants treated with B exhibited maximum seed nitrogen, pods per plant, and biological yield compared to other treatments. Overall, plants treated with Ca and B nanoparticles and mycorrhiza exhibited remarkable improvement in their growth, yield, and biochemical attributes, suggesting that nanotechnology and biofertilization are steps toward environmentally friendly, progressive farming. This study laid the basis for further elucidation of the molecular mechanism of plants in response to these nanoparticles and biofertilizers.
Sdy-1 Executes Antitumor Activity in HepG2 and HeLa Cancer Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway

Demethylincisterol A3 (Sdy-1), a highly degraded sterol that we previously isolated from Chinese mangrove Rhizophora mucronata endophytic Pestalotiopsis sp. HQD-6, exhibits potent antitumor activity towards a variety of cancer cells. In this study, we further verified that Sdy-1 effectively inhibited the proliferation and migration of human liver (HepG2) and cervical cancer (HeLa) cells in vitro and it can induce cell apoptosis and arrest the cell cycle in the G1-phase. Mechanistically, we demonstrated that Sdy-1 executes its function via inhibition of the Wnt/β-catenin signaling pathway. Sdy-1 may not inhibit the Wnt signaling pathway through the cascade reaction from upstream to downstream, but directly acts on β-catenin to reduce its transcription level, thereby reducing the level of β-catenin protein and further reducing the expression of downstream related proteins. The possible interaction between Sdy-1 and β-catenin protein was further confirmed by molecular docking studies. In the nude mouse xenograft model, Sdy-1 can also significantly inhibit tumor growth. These results indicated that Sdy-1 is an efficient inhibitor of the Wnt signaling pathway and is a promising antitumor candidate for therapeutic applications.
Development of pasta products using cereal pulse blends

Pasta products are one of the most ancient food forms in which wheat has been consumed. A study was conducted to prepare spaghetti with the incorporation of cereal pulse blends and to find out its keeping quality when packed in polyethylene bags of 200 gauge (P1) and 400 gauge (P2) stored at room temperature. The cooking qualities, nutritional and organoleptic characteristics of spaghetti were assessed during the storage period of 180 days. The cooking time, cooked volume, cooked weight and water absorption except cooking loss of spaghetti was decreased with the addition of cereal pulse blends. A gradual increase in moisture, protein, fat, crude fibre and ash content was observed in cereal pulse blended spaghetti. T1 and T2 samples was found to be the best treatments which contained minimum cooking time and cooking loss and more nutrients and also scored the maximum score for all the sensory attributes among the other cereal pulse blended samples. All the spaghetti samples packed in packaging material P2 retained more nutrients than P1. P2 had lesser microbial load than P1. Cereal pulse blended spaghetti packed in both the packaging material (P1 and P2) had an equal acceptability interms of organoleptic characteristics during storage. The cost of production of cereal pulse blended spaghetti is lesser than the market sample.
Are serum levels of inflammatory markers associated with the severity of symptoms of bipolar disorder?

Background To explore the relationship between serum levels of inflammatory markers and symptomatic severity of bipolar disorder (BD). Materials and methods A cross-sectional study was conducted on 126 BD patients with current depressive episode (BDD), 102 BD patients with current mixed or (hypo)manic episode (BDM) and 94 healthy controls (HC). All participants were drug-naïve and had no current active physical illness associated with inflammatory response or history of substance abuse. Fasting serum levels of CRP, leptin (LEP), adiponectin (ADP), visfatin (VIS), TNF-α, IL-2, IL-6, IL-10, IL-17), and monocyte chemoattractant protein-1 (MCP-1) were measured with enzyme-linked immunosorbent assay (ELISA). Symptomatic severity of BD was assessed with HAMD-17 and YMRS. Generalized linear model was used to determine the association between the serum levels of inflammatory markers and symptomatic severity of BD. Results The serum levels of IL-6, IL-10 and IL-17, and the IL-6/IL-10 ratio were significantly lower in mild BDD than in HC. In moderate BDD, the serum levels of MCP, IL-6 and IL-17 were significantly lower than in HC. In severe BDD, the serum level of ADP, MCP-1, IL-10 and IL-17and the IL-17/IL-10 ratio were significantly lower than in HC. The serum levels of TNF-α and the IL-6/IL-10 ratio were significantly higher in mild BDM than in HC. In moderate BDM, the serum level of VIS, IL-2, and IL-17 were significantly higher than in HC, but the IL-6/IL-10 ratio was significantly lower than in control. In severe BDM, the serum levels of IL-6 and IL-17 and the ratios of IL-6/IL-10 and IL-17/IL-10 were significantly lower than in HC, but the neutrophil/lymphocyte ratio was significantly higher than in HC. Conclusion In BDD, immune-inhibition is persistently predominant, while in mild-to-moderate BDM, immune system is activated but inhibited in severe BDM. The dynamic change of serum inflammatory markers suggests that alteration of peripheral inflammatory markers in BD is state-dependent instead of trait-marked.
A robust optimisation model for hybrid remanufacturing and manufacturing systems under uncertain return quality and market demand

In remanufacturing research, most researchers predominantly emphasised on the recovery of whole product (core) rather than at the component level due to its complexity. In contrast, this paper addresses the challenges to focus on remanufacturing through component recovery, so as to solve production planning problems of hybrid remanufacturing and manufacturing systems. To deal with the uncertainties of quality and quantity of product returns, the processing time of remanufacturing, remanufacturing costs, as well as market demands, a robust optimisation model was developed in this research and a case study was used to evaluate its effectiveness and efficiency. To strengthen this research, a sensitivity analysis of the uncertain parameters and the original equipment manufacturer’s (OEM’s) pricing strategy was also conducted. The research finding shows that the market demand volatility leads to a significant increase in the under fulfilment and a reduction in OEM’s profit. On the other hand, recovery cost reduction, as endogenous cost saving, encourages the OEM to produce more remanufactured products with the increase in market demand. Furthermore, the OEM may risk profit loss if they raise the price of new products, and inversely, they could gain more if the price of remanufactured products is raised.