Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical Relevance and Diversity of Two Homologous Genes Encoding Glycosyltransferases in Helicobacter pylori (cid:1)

Helicobacter pylori is known to be a major cause of peptic ulceration. The jhp0562 gene, encoding a glycosyltransferase involved in the synthesis of the lipopolysaccharide, was associated with peptic ulcer disease (PUD) in children. The (cid:1) -(1,3)-galactosyltransferase [ (cid:1) -(1,3)GalT] gene ( jhp0563 ), involved in Lewis (Le) antigen expression, is highly similar to jhp0562 . The clinical signiﬁcance and diversity of both genes were examined by PCR and sequencing of clinical strains ( n (cid:2) 117) isolated from children with PUD ( n (cid:2) 57) and nonulcer dyspepsia (NUD; n (cid:2) 60). The prevalence of the jhp0562 gene was signiﬁcantly higher in strains with a more-virulent proﬁle (strains positive for the cag pathogenicity island [PAI], vacA sl allele, , homB , phase-variable gene oipA “on” [i.e., functional], and hopQ I allele). The distribution of genotypes according to clinical outcome showed that the presence of jhp0562 represented one of the greatest risks for the development of PUD. Moreover, the triple-positive genotype for the cag PAI, jhp0562 , and homB provided the best discriminatory model for distinguishing PUD and NUD outcomes in children. Sequence and in vitro expression analyses of jhp0562 showed the presence of a complete open reading frame, while the (cid:1) -(1,3)GalT gene was shown to be a phase-variable gene. The regular presence of jhp0562 in strains with a truncated (cid:1) -(1,3)GalT gene suggests that jhp0562 may also be implicated in the regulation of Le antigen expression. Overall, the results of this study suggest that the jhp0562 gene is of great clinical relevance, being a useful comarker for severe H. pylori -related disease and contributing to host adaptation. METHODS Patients and H. pylori bacterial strains. A total of 117 H. pylori strains isolated from children attending the three pediatric gastroenterology units in the Lisbon area (Portugal) for upper gastrointestinal symptoms were exam- ined in this study. These strains belong to the collection of H. pylori strains in the Department of Infectious Diseases of the Instituto Nacional Sau´de Dr. Ricardo Jorge, in Portugal. Fifty-seven children presented with PUD (53 with DU and 4 with gastric ulcers), and 60 presented with abdominal pain and gastritis only, categorized as NUD. The characteristics of the study population are described in Table 1.
Analysis on the Sequential Dynamic Change in Electromyogram Recorded from Shoulder Muscles during Throwing

The purpose ef this study was to show the clynamic change in musc]e activity of the individuul muscles during threwing, whereas previous sLudies shoxved an intcgrated average muscle activity in each throwing phase. E! ectromyographic: signals (EMGs) were recorded with fine wire clectrodes frem the supraspinatus, the teres minor, and the subsc:apuralis of a universiLy baseball pitcher. EMG from the infraspinatus was recorded using active surface electrodes, Root menn square vatues of EMGs were caLculated as a percentage of the maximal voluntary contraction (nR}vlS}. The acceleration of sheutder joint was calculated v{deo coerucient of variation which a variable in each muscle among ten times repeated showed charucteristics depending on museles. the
Ethical and Socially Responsible Behaviour of Tax Advisers: The Case of Moral Beliefs

Financial crisis and corporate scandals have turned the spotlight on the role played by tax advisors in the creation and development of tax minimization schemes. This paper explores whether society is entitled to expect tax advisors to behave in an ethical and socially responsible manner and to have general moral obligations. A modern contradictory role of tax advisors has been analyzed, influencing a predatory entrepreneurial culture, and the conflicting mental attitude of society and clients have been investigated. The study concludes that significant differences in tax advisors’ ethical sensitivity and personal moral beliefs have been insurmountable obstacles to meeting these expectations thus far.
Validation of a Diabetic Retinopathy

Background: Visual impairment and blindness from diabetic retinopathy (DR), which can be reduced by early screening and treatment, is an emerging public health concern in low-income and middle-income countries (LMICs) owing to the increasing prevalence of diabetes mellitus (DM). However, no systematic screening exists in most LMIC settings. The Western province of Sri Lanka has the highest prevalence of DM (18.6%) in the country. A situational analysis identified a marked gap in DR screening (DRS) and treatment services uptake in this region; only opportunistic screening is practiced currently. this to describe the methods of development and validation of a DRS intervention using a hand-held nonmydriatic digital camera by physician graders in a non-ophthalmological setting at a tertiary-level medical clinic a valid and feasible modality to improve uptake. 2-field validity screening will be with the indirect biomicroscopic The validity of screening by physician graders will be analyzed and the sensitivity, specificity, and predictive values (with 95% CIs) calculated by the dilation status and for each grader. The diagnostic accuracy at each level of severity of DR will be assessed to define the most appropriate referable criteria. Data is currently being collected. study of a of at non-ophthalmological setting to eye in advance to prevent sight-threatening DR. Furthermore, evidence from this study will be useful for the implementation of a DRS program in this region and in similar communities.
Software Support for Waste Oil Management

: - Regeneration is an environmentally beneficial and energy-efficient method of managing used oil. Less energy is required to produce a liter of regenerated base stock than a liter of crude oil. Once the contaminants are removed from collected used oil, it is as good as new, returned to a full and useful life, "closing the recycling loop. " Of course, the regeneration technology depends on many factors – type of contaminants, available budget, yield and quality of the main product, scalability, development stage, environmental friendliness, etc. Therefore, we have developed a software package to help decision makers to select the regeneration technology that best suits their own criteria and preferences. The tool is easy to use, Web accessible, Java based, and implements PROMETEE outranking method as a preferable multicriteria decisionmaking paradigm
during Intestinal Inflammation Functions Contributes to Regulatory Immune Reprogramming of Monocytes by GM-CSF

Human and murine studies showed that GM-CSF exerts beneﬁcial effects in intestinal inﬂammation. To explore whether GM-CSF mediates its effects via monocytes, we analyzed effects of GM-CSF on monocytes in vitro and assessed the immunomodulatory potential of GM-CSF–activated monocytes (GMaMs) in vivo. We used microarray technology and functional assays to charac-terize GMaMs in vitro and used a mouse model of colitis to study GMaM functions in vivo. GM-CSF activates monocytes to increase adherence, migration, chemotaxis, and oxidative burst in vitro, and primes monocyte response to secondary microbial stimuli. In addition, GMaMs accelerate epithelial healing in vitro. Most important, in a mouse model of experimental T cell– induced colitis, GMaMs show therapeutic activity and protect mice from colitis. This is accompanied by increased production of IL-4, IL-10, and IL-13, and decreased production of IFN- g in lamina propria mononuclear cells in vivo. Conﬁrming this ﬁnding, GMaMs attract T cells and shape their differentiation toward Th2 by upregulating IL-4, IL-10, and IL-13 in T cells in vitro. Beneﬁcial effects of GM-CSF in Crohn’s disease may possibly be mediated through reprogramming of monocytes to simulta-neously improved bacterial clearance and induction of wound healing, as well as regulation of adaptive immunity to limit excessive inﬂammation. Journal of Immunology , 2015, 194: 000–000.
Exploring Author Profiling for Fake News Detection

The proliferation of online media allows for the rapid dissemination of unmoderated news, unfortunately including fake news. The extensive spread of fake news poses a potent threat to both individuals and society. This paper focuses on designing author profiles to detect authors who are primarily engaged in publishing fake news articles. We build on the hypothesis that authors who write fake news repeatedly write only fake news articles, at least in short-term periods. Fake news authors have a distinct writing style compared to real news authors, who naturally want to maintain trustworthiness. We explore the potential to detect fake news authors by designing authors' profiles based on writing style, sentiment, and co-authorship patterns. We evaluate our approach using a publicly available dataset with over 5000 authors and 20000 articles. For our evaluation, we build and compare different classes of supervised machine learning models. We find that the K-NN model performed the best, and it could detect authors who are prone to writing fake news with an 83% true positive rate with only a 5% false positive rate.
A Machine Learning Approach to Violin Vibrato Modelling in Audio Performances and a Didactic Application for Mobile Devices

We present a machine learning approach to model vibrato in classical music violin audio performances. A set of descriptors have been extracted from the music scores of the performed pieces and used to train a model for classifying notes into vibrato or non-vibrato, as well as for predicting the performed vibrato amplitude and frequency. In addition to score features we have included a feature regarding the ﬁngering used in the performance. The results show that the ﬁngering feature affects consistently the prediction of the vibrato amplitude. Finally, an implementation of the resulting models is proposed as a didactic real-time feed-back system to assist violin students in performing pieces using vibrato as an expressive resource.
Separating Interviewer and Sampling-Point Effects 1

: Data used in nationwide face-to-face surveys are always collected in multistage cluster samples. The relative homogeneity of the clusters selected in this way can lead to design effects at the sampling stage. Interviewers can further homogenize answers within the sampling points. The study presented here was designed to separate between interviewer effects and sampling-point effects using interpenetrated samples for conducting a nationwide survey on fear of crime. Even though one might, given the homogeneity of neighborhoods, assume that sampling-point effects would be especially strong for questions related to fear of crime in one’s neighborhood, we found that, for most items, the interviewer was responsible for a greater share of the homogenizing effect than was spatial clustering. This result can be understood if we recognize that these questions are part of a larger class of survey questions whose subject matter is either unfamiliar to the respondent or otherwise not well anchored in the mind of the respondent. These questions permit differing interpretations to be elicited by the interviewer.
Semi Supervised Grading Model Using Syntactic Level Feature Selection Technique

Cancer prognosis and the course of treatment chosen are based on the grade of malignancy present as observed in the images. Deep learning approaches have resulted in encouraging outcomes on histopathology images at different levels, such as detection, segmentation, and classiﬁcation. In this paper, we examine the application of deep learning and image processing techniques to perform automatic breast cancer malignancy grading from histopathology images of Hematoxylin and Eosin (H&E) stains. To determine the grade of malignancy slide, ROI is ﬁrst extracted from the pre-processed malignant images. From this features were extracted by an intensity level and texture of images, which describe the proportions of nuclei belonging to the various grades, in conjunction with pixel-level feature, and object-level feature. In this study we propose a rough set-based syntactic feature selection method (SFSM)-to create an integrated set of image attributes that can potentially differentiate the varies grades of malignancy image features. Finally, cancer grade was determined by reducing feature vector and classiﬁed by the individual Xg-boosting model. Thus, the framework can be clinically used for accurate and rapid diagnosis of breast cancer.
Cell-to-Cell Communication and Signaling Pathways Inhibitory effects of openers of large-conductance Ca 2 (cid:2) -activated K (cid:2) channels on agonist-induced phasic contractions in rabbit and mouse bronchial smooth muscle

Inhibitory effects of openers of large-conductance Ca 2 (cid:2) -activated K (cid:2) channels on agonist-induced phasic contractions in rabbit and mouse bronchial smooth muscle. Am J Physiol Cell Physiol 315: C818–C829, 2018. First published September 26, 2018; doi:10.1152/ajpcell.00068. 2018. —Airway smooth muscle expresses abundant BK Ca channels, but their role in regulating contractions remains controversial. This study examines the effects of two potent BK Ca channel openers on agonist-induced phasic contrac- tions in rabbit and mouse bronchi. First, we demonstrated the ability of 10 (cid:3) M GoSlo-SR5-130 to activate BK Ca channels in inside-out patches from rabbit bronchial myocytes, where it shifted the activation V 1/2 by (cid:4) 88 (cid:5) 11 mV (100 nM Ca 2 (cid:2) , n (cid:6) 7). In mouse airway smooth muscle cells, GoSlo-SR5-130 dose dependently shifted V 1/2 by 12–83 mV over a concentration range of 1–30 (cid:3) M. Compound X, a racemic mixture of two enantiomers, reported to be potent BK Ca channel openers, shifted V 1/2 by 20–79 mV over a concentration range of 0.3–3 (cid:3) M. In rabbit bronchial rings, exposure to histamine (1 (cid:3) M) induced phasic contractions after a delay of ~35 min. These were abolished by GoSlo-SR5-130 (30 (cid:3) M). Nifedipine (100 nM) and CaCC inh A01 (10 (cid:3) M), a TMEM16A blocker, also abolished hista-mine-induced phasic contractions. In mouse bronchi, similar phasic contractions were evoked by exposure to U46619 (100 nM) and carbachol (100 nM). In each case, these were inhibited by concentrations of GoSlo-SR5-130 and compound X that shifted the activation V 1/2 of BK Ca channels in the order of (cid:4) 80 mV. In conclusion, membrane potential-dependent regulation of L-type Ca 2 (cid:2) channels appears to be important for histamine-, U46619-, and carbachol-induced phasic contractions in airway smooth muscle. Contractions can be abolished by BK Ca channel openers, suggesting that these channels are potential targets for treating some causes of airway obstruction.
Problems Faced While Simulating Nanofluids Problems Faced While Simulating Nanofluids

Problems are faced when something is already been adopted for a considerable amount of time–here the problem that is discussed is related with nanofluids. The nanofluids have been considered for different engineering applications since last three decades; how - ever, the work on its simulation has been started since last two decades. With the time, nanofluid simulations are increasing as compared to experimental testing. Researchers conducting nanofluid simulations do find difficulties and problems while trying to simu late this system. In addition to this, most of the time researchers are unaware of some basic problems and they find themselves stuck in relentless difficulties. Most of the time, these problems are very basic and can waste a lot of useful time of a research. Therefore, this chapter introduces some fundamental problems which a researcher can find while simulating nanofluids and with a simple way of dealing with it. Moreover, the chapter withholds lots of information regarding the way to design and to model a nanofluid system. Not only this, it also tends to elaborate the nanofluid simulation methodology in a precise manner. Moreover, the literature shows that nanofluid simulation has gained high consideration since last two decades, as experimental techniques are out of reach for everyone. In addition to experimental techniques, they are expensive, time-consuming and require high skills. However, it seems the simulation is picking pace with the due time and is considerably being adopted by the expertise dealing with nanofluids. This opens a high prospect of simulating nanofluids in future. Nevertheless, it seems there will be user-friendly software to conduct nanofluid simulations. Finally, issues and their resolution have also been conveyed which is the main aspect of this
Chen, Xi and Zou, Kun and Abdullah, Natasya and Whiteside, Nicola and Sarmanova, Aliya and Doherty, Michael and Zhang, Weiya (2017) The placebo effect and its determinants in fibromyalgia: meta-analysis of randomized controlled trials. Clinical Rheumatology . ISSN 1434-9949

The aims of this study were to determine whether placebo treatment in randomised controlled trials (RCTs) is effective for fibromyalgia and to identify possible determinants of the magnitude of any such placebo effect. A systematic literature search was undertaken for RCTs in people with fibromyalgia that included a placebo and/or a no-treatment (observation only or waiting list) control group. Placebo effect size (ES) for pain and other outcomes wasmeasured as the improvement of each outcome from baseline divided by the standard deviation of the change from baseline. This effect was compared with changes in the no-treatment control groups. Metaanalysis was undertaken to combine data from different studies. Subgroup analysis was conducted to identify possible determinants of the placebo ES. A total of 3912 studies were identified from the literature search. After scrutiny, 229 trials met the inclusion criteria. Participants who received placebo in the RCTs experienced significantly better improvements in pain, fatigue, sleep quality, physical function, and other main outcomes than those receiving no treatment. The ES of placebo for pain relief was clinically moderate (0.53, 95%CI 0.48 to 0.57). The ES increased with increasing strength of the active treatment, increasing participant age and higher baseline pain severity, but decreased in RCTS with more women and with longer duration of fibromyalgia. In addition, placebo treatment in RCTs is effective in fibromyalgia. A number of factors (expected strength of treatment, age, gender, disease duration) appear to influence the magnitude of the placebo effect in this condition.
Computing Frequent k -Itemsets Directly in Sparse Datasets

In this paper we show that the well known problem of computing frequent k -itemsets (i.e. itemsets of cardinality k ) in a given dataset can be reduced to the problem of ﬁnding iceberg queries from a stream of queries suitably constructed from the original dataset. Hence, algorithms for computing frequent k -itemsets can be obtained by adapting algorithms for computing iceberg queries. In the paper we show that, for sparse datasets, this can be done directly, i.e. without generating frequent x -itemsets, for each x < k , as done in the most common algorithms based on a level-wise approach. We exploit a recent algorithm for ﬁnding iceberg queries and deﬁne an algorithm which requires only three sequential passes over the dataset to compute the frequent k -itemsets (even for k > 3). An important feature of the algorithm is that the amount of main memory required can be determined in advance, and it is shown to be very low for sparse datasets. Experiments show that for very large datasets with millions of small transactions our proposal outperforms the state-of-the-art algorithms.
Fast contact evolution for piecewise smooth surfaces

Dynamics simulation of smooth bodies in contact is a critical problem in physically based animation and interactive virtual environments. We describe a technique which uses reduced coordinates to evolve a single continuous contact between Loop subdivision surfaces. The incorporation of both slip and no-slip friction into our algorithm is straightforward. The dynamics equations, though slightly more complex due to the reduced coordinate formulation, can be integrated easily using explicit integrators without the need for constraint stabilization. The use of reduced coordinates also confines integration errors to lie within the constraint manifold which is preferable for visualization. Our algorithm is suitable for piecewise parametric or parameterizable surfaces with polygonal domain boundaries. Because a contact will not always remain in the same patch, we demonstrate how a contact can be evolved across patch boundaries. We also address the issue of non-regular parameterizations occurring in Loop subdivision surfaces through surface replacement with n sided S-patch surfaces. Three simulations show our results. We partially verify our technique first with a frictionless system and then with a blob sliding and rolling inside a bowl. Our third simulation shows that our formulation correctly predicts the spin reversal of a rattleback top. We also present timings of the various components of the algorithm.
Off-grid Solar Power Systems in Rural Areas

Engineers Without Borders Haugalandet was commissioned by the organization Haugesund Rotifunk to review the possibility of providing a reliable power supply at the Hatfield Archer Memorial Hospital in Sierra Leone. An off-grid solar power system was chosen as the best solution. In this thesis, the solar power system has been assessed to see if it is sufficient for its intended use. The assessment of the ongoing project at the hospital showed that the solar power system is satisfactory, given the invested funds. For the system to be able to provide power to all connected loads, it would need to be expanded. However, with correct use and maintenance, the system should provide a considerable amount of energy, giving the hospital a more reliable power source. Off-grid Solar Power Systems in Rural Areas ii Table of Content Preface . i Table of Content . ii List of Figures . v List of Tables . v Table of Acronyms and Abbreviations . vi Summary . vii Sammendrag . viii