Miracle-dz/UniFAR-FTUs huggingface dataset:
Lipid peroxidation processes in men with type 1 diabetes mellitus following α-lipoic acid treatment

In various pathological conditions such as diabetes mellitus, the cellular redox balance can be disturbed and these alterations may persist even after blood glucose levels have returned to normal. Antioxidant therapies, including α-lipoic acid, are widely used to treat various systemic diseases including diabetes mellitus. The aim of this study was to measure the lipid metabolism parameters, as well as the activity of lipid peroxidation and antioxidant defense reactions, in men with type 1 diabetes mellitus (T1DM) during treatment with α-lipoic acid. Twenty-four reproductive-age T1DM males with an unsatisfactory glycemic profile were examined. Twenty-eight practically healthy men of similar age were used as the control group. Spectrophotometric, fluorometric, and enzyme-linked immunoassay methods were used. T1DM was characterized by increased values of lipid metabolism components, including total cholesterol, triacylglycerides (TG), and very-low-density lipoproteins (VLDL). In the lipid peroxidation system, increased levels of the primary products (conjugated dienes), secondary products (thiobarbituric acid reactants), and final products (Schiff bases) were observed in T1DM patients compared to the control group. Retinol values were also increased. After treatment, there was a decrease in TG, VLDL, and Schiff bases levels and an increase in the retinol level compared to before treatment. These results expand our understanding of the pathogenetic mechanisms of T1DM and suggest that α-LA treatment may be beneficial for type 1 diabetics.
Demonstration Of An HTS SQUID System For Nondestructive Evaluation

Abstract : This report results from a contract tasking University of Strathclyde as follows: This report describes the work done by Dr. Jan Kuznik at the University of Strathclyde from I May 1995 until 31 Jul 1995. In accordance with the proposal, the main objective was to illustrate the feasibility of an eddy current nondestructive evaluation (NDE) measurement system based on high-Tc SQUIDS in an ordinary laboratory environment without any magnetic shielding. A series of aluminum and steel samples with artificial and real cracks were investigated under these conditions.
A Decade of Lymphoma-Associated Hemophagocytic Lymphohistiocytosis: Does the Outcome Improve?

To investigate the potential treatment evolution and outcome improvement, we retrospectively compared clinical characteristics, therapeutic strategies, treatment responses, and overall survival (OS) in patients diagnosed and treated with lymphoma-associated HLH between 2004–2012 (n = 30) and 2013–2021 (n = 26). Our study showed that the clinical characteristics of lymphoma-associated HLH did not substantially change over the past two decades. However, more patients diagnosed in 2013–2021 were tested for Epstein–Barr virus than those diagnosed in 2004–2012 (69.3% vs. 33.3%; p = 0.021). In addition, Eastern Cooperative Oncology Group performance status 3–4 (hazard ratio (HR): 5.38; 95% confidence intervals (CI): 2.49–11.61; p < 0.001) and jaundice (HR: 2.91; 95% CI: 1.37–6.18; p = 0.006) were poor prognostic factors for lymphoma-associated HLH. With a comparable response rate of lymphoma treatment, patients treated in 2013–2021 had a numerically greater median OS than those treated in 2004–2012 (23.6 ± 19.8 vs. 9.7 ± 4.5 months). However, the difference was not statistically significant (p = 0.334). In conclusion, early diagnosis and tailored treatments that balance efficacy and adverse events remain the key to obtaining a better outcome in lymphoma-associated HLH.
A smart access control mechanism based on user preference in online social networks

Access control can effectively protect users' data and privacy in social networks. Different access control models address different data privacy requirements, and the corresponding implementation technologies and performance are also quite different. The existing access control mechanisms of social networks rarely take into account the individual preferences of users, and cannot provide personalized services for users. Therefore, we have studied an analysis mechanism of user preference to quantify user preferences, and then use user preference values and some key information of users' social resources as decision vectors, and proposed an access control mechanism based on user preference (ACMBUP). ACMBUP turns the problem of access decision‐making into a problem of classification, that is, whether to allow access or not to allow access. At the same time, we add an encryption and decryption mechanism in ACMBUP to prevent data leakage and protect data when users interact with access mechanisms. Experiments show that this mechanism can automatically generate appropriate access control policies to meet the potential privacy needs of different users, so as to better protect the privacy of social networks data.
Liquid Crystal Thermography in Gas Turbine Heat Transfer: A Review on Measurement Techniques and Recent Investigations

Liquid Crystal Thermography is a widely used experimental technique in the gas turbine heat transfer community. In turbine heat transfer, determination of the convective heat transfer coefficient (h) and adiabatic film cooling effectiveness (η) is imperative in order to design hot gas path components that can meet the modern-day engine performance and emission goals. LCT provides valuable information on the local surface temperature, which is used in different experimental methods to arrive at the local h and η. The detailed nature of h and η through LCT sets it apart from conventional thermocouple-based measurements and provides valuable insights into cooling designers for concept development and its further iterations. This article presents a comprehensive review of the state-of-the-art experimental methods employing LCT, where a critical analysis is presented for each, as well as some recent investigations (2016–present) where LCT was used. The goal of this article is to familiarize researchers with the evolving nature of LCT given the advancements in instrumentation and computing capabilities, and its relevance in turbine heat transfer problems in current times.
Empirical Modeling of Air Tightness in Residential Homes in North Louisiana

The measure of air-tightness in residential homes quantifies air leakage sites by measuring the airflow between the home and the outside in a range of pressures. Estimating air-tightness on the basis of certain physical characteristics of the home instead of actually measuring it is advantageous to homeowners as well as energy auditors. The objective of this study is to develop a region-specific empirical model to estimate air-tightness in residential homes. The air-tightness was measured for sixty-six homes in northern parts of Louisiana, USA. The three common air-tightness measures – CFM50, ELA, EqLA are used to develop three different multiple regression models based on the year of construction, floor area, number of bedrooms, and number of storeys of the homes. The predictive power for the three different models is also calculated. This case study is accessible to readers with a basic knowledge of statistics.
Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]Pyridazinone Exert Anti-Inflammatory Activity without Acute Gastrotoxicity in the Carrageenan-Induced Rat Paw Edema Test

Background and Purpose Due to the risk of gastrointestinal damage and various tissue toxicity associated with non-steroidal anti-inflammatory drugs (NSAIDs) use, investigating new anti-inflammatory agents with efficacy comparable to that of NSAIDs but reduced toxicity is still a major challenge and a clinical need. Based on our previous study, new 1,3,4-oxadiazole derivatives of pyrrolo[3,4-d]pyridazinone, especially 6-butyl-3,5,7-trimethyl-1-[[4-[[4-(4-nitrophenyl)piperazin-1-yl]methyl]-5-thioxo-1,3,4-oxadiazol-2-yl]methoxy]pyrrolo[3,4-d]pyridazin-4-one and 6-butyl-1-[[4-[[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]methyl]-2-thioxo-1,3,4-oxadiazol-5-yl]methoxy]-3,5,7-trimethyl-pyrrolo[3,4-d]pyridazin-4-one (hereafter referred to as the compounds 10b and 13b, respectively) seem to be promising anti-inflammatory agents. This study aimed to elucidate the effects of these two new derivatives on the course of experimental rat inflammation, liver and kidney function, and gastric mucosa. Methods The anti-inflammatory effect of compounds 10b and 13b was evaluated using the carrageenan-induced paw edema test in rats. The increase in paw volume (paw edema), prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α) and myeloperoxidase (MPO) levels, histological alterations, and inflammatory cell infiltration in paw tissue were determined. Serum alanine transaminase (ALT) and aspartate transaminase (AST) activities, serum urea and creatinine levels, as well as changes in gastric mucosa, were measured as indicators of hepatic, renal, and gastric toxicity. Results Pretreatment with both novel derivatives at 10 mg/kg and 20 mg/kg doses reduced paw edema, counteracted the increased PGE2 and TNF-α levels, reduced the influx of inflammatory cells, and decreased histopathological alterations in paw tissue. Compound 13b at a dose of 20 mg/kg was more effective than indomethacin in reversing the increased TNF-α levels and reducing the influx of inflammatory cells. Only compound 13b at all studied doses (5, 10, or 20 mg/kg) counteracted the increased MPO level in paw tissue. Both compounds neither caused alterations in ALT, AST, urea, creatinine parameters nor gastric mucosal lesions. Conclusion New compounds exert an anti-inflammatory effect, presumably via inhibiting inflammatory mediators release and inflammatory cell infiltration. Moreover, both possess a more favorable benefit–risk profile than indomethacin, especially compound 13b.
Data Transmission Reduction in Wireless Sensor Network for Spatial Event Detection

Wireless sensor networks have found many applications in detecting events such as security threats, natural hazards, or technical malfunctions. An essential requirement for event detection systems is the long lifetime of battery-powered sensor nodes. This paper introduces a new method for prolonging the wireless sensor network’s lifetime by reducing data transmissions between neighboring sensor nodes that cooperate in event detection. The proposed method allows sensor nodes to decide whether they need to exchange sensor readings for correctly detecting events. The sensor node takes into account the detection algorithm and verifies whether its current sensor readings can impact the event detection performed by another node. The data are transmitted only when they are found to be necessary for event detection. The proposed method was implemented in a wireless sensor network to detect the instability of cargo boxes during transportation. Experimental evaluation confirmed that the proposed method significantly extends the network lifetime and ensures the accurate detection of events. It was also shown that the introduced method is more effective in reducing data transmissions than the state-of-the-art event-triggered transmission and dual prediction algorithms.
Parents’ Experiences with Home-Based Oral Chemotherapy Prescribed to a Child Diagnosed with Acute Lymphoblastic Leukemia: A Qualitative Study

Acute lymphoblastic leukemia (ALL) is the most common type of cancer in children. Treatment includes home-based oral chemotherapies (OCs) (e.g., 6-mercaptopurine and dexamethasone) taken for 2 to 3 years. The management of OC can be challenging for children and their parents. However, the multifaceted experience of families with children taking OC for ALL is largely undescribed. We report the experience with these OCs from the parents’ perspective. We conducted a qualitative descriptive study. Semi-structured interviews were conducted with the parents of children with ALL aged < 15 years, followed in a specialized university-affiliated center. The interviews were fully transcribed and thematically analyzed. Thirteen of the seventeen eligible parents (76.5%) participated in the study. The parents’ motivation to follow the recommendations provided by the multidisciplinary care team regarding OC was very high. The quantity and the quality of the information received were judged adequate, and the parents reported feeling knowledgeable enough to take charge of the OC at home. Adapting to the consequences of OC on family daily life was collectively identified as the biggest challenge. This includes developing and maintaining a strict daily routine, adapting to the child’s neurobehavioral changes during dexamethasone days and adapting family social life. Our findings have several implications for enhancing the support offered to families with home-based OC for ALL. Supportive interventions should consider the family as a whole and their needs should be regularly monitored. Specific attention should be paid to the development and maintenance of a routine, to the parental burden, and to the emotional impact, especially regarding dexamethasone.
Differential p53-Mediated Cellular Responses to DNA-Damaging Therapeutic Agents

The gene TP53, which encodes the tumor suppressor protein p53, is mutated in about 50% of cancers. In response to cell stressors like DNA damage and after treatment with DNA-damaging therapeutic agents, p53 acts as a transcription factor to activate subsets of target genes which carry out cell fates such as apoptosis, cell cycle arrest, and DNA repair. Target gene selection by p53 is controlled by a complex regulatory network whose response varies across contexts including treatment type, cell type, and tissue type. The molecular basis of target selection across these contexts is not well understood. Knowledge gained from examining p53 regulatory network profiles across different DNA-damaging agents in different cell types and tissue types may inform logical ways to optimally manipulate the network to encourage p53-mediated tumor suppression and anti-tumor immunity in cancer patients. This may be achieved with combination therapies or with p53-reactivating targeted therapies. Here, we review the basics of the p53 regulatory network in the context of differential responses to DNA-damaging agents; discuss recent efforts to characterize differential p53 responses across treatment types, cell types, and tissue types; and examine the relevance of evaluating these responses in the tumor microenvironment. Finally, we address open questions including the potential relevance of alternative p53 transcriptional functions, p53 transcription-independent functions, and p53-independent functions in the response to DNA-damaging therapeutics.
The Influence of Plants from the Alliaceae Family on Morphological Parameters of the Intestine in Atherogenic Rats

Bulbs from the Alliaceae family have been well-known and valued spices for thousands of years, not only for their unique flavor and aroma features, but also for their high nutritional and health-promoting values. Long-term or excessive consumption of these vegetables, especially raw garlic, can have side effects in the body (including in the digestive tract), causing a number of pathological changes in the intestinal wall; these changes lead, in turn, to its damage, dysfunction, and disorder development. Therefore, the aim of this study was to investigate the effect of the addition of freeze-dried vegetables from the Alliaceae family, i.e., garlic (Allium sativum L.), white onion, and red onion (Allium cepa L.) on the morphometric parameters (intestinal villi length, crypt depth, thickness of tunica mucosa, and the thickness of tunica muscle) of the jejunum of rats fed a semi-synthetic atherogenic diet (1% dietary cholesterol). In freeze-dried vegetables administered to rats, the contents of selected bioactive ingredients and their antioxidant potentials were determined. The effect of the onion vegetable supplements on growth parameters, serum lipid profile, plasma antioxidant potential, and the intestinal morphological parameters of rats loaded with cholesterol was determined. In an animal experiment, 30 male Wistar rats were divided into 5 diet groups, diet consumption and FER were studied. Supplementation of the atherogenic diet with vegetables improved the blood plasma lipid profiles and atherogenic indices, in a manner that was dependent on the type of supplementation used, with the best hypolipidemic and anti-atherosclerotic effects found in garlic use. The atherogenic diet, as well as the supplementation of this diet with the tested vegetables from the Alliaceae family, influenced the histological changes in the epithelium of the jejunum of rats. The damage to the intestinal mucosa was the greatest in animals fed an atherogenic diet supplemented with garlic. Bearing in mind that the desired beneficial therapeutic or prophylactic effects of onion vegetables (in particular garlic) in the course of various metabolic ailments (including atherosclerosis) are achieved during long-term supplementation, it is important to remember their possible cytotoxic effects (e.g., on the digestive tract) in order to achieve real benefits related to the supplementation with vegetables from the Alliaceae family.
Subjective Social Status Is Associated with Dysregulated Eating Behaviors and Greater Body Mass Index in an Urban Predominantly Black and Low-Income Sample

Background: Higher subjective social status (SSS) or a person’s perception of their social standing is related to better health outcomes, but few studies examined SSS in relation to obesity. Emotional eating and food addiction have been linked to obesity. Some studies indicated that manipulating SSS may lead to altered food intake, but the relationship between SSS and dysregulated eating, such as emotional eating and food addiction (FA), has not been examined. The goal of this study was to examine the associations between SSS in the community and the larger society, dysregulated eating (emotional eating and FA), and body mass index (BMI) in a majority racial minority sample. Methods: The participants (N = 89; 93% Black, 86% women, and 56% with obesity; 72% income lower than USD 2000), recruited from a publicly funded hospital in Atlanta, GA, completed the MacArthur Scale, Dutch Eating Behaviors Questionnaire, Yale Food Addiction Scale, Beck Depression Inventory, PTSD Symptom Checklist, and demographics questionnaire. Results: Twenty-two percent of the sample met the criteria for FA; those with FA had significantly higher BMI than those without (p = 0.018). In the hierarchical linear regression, the SSS community (but not in society) predicted higher severity of emotional eating (β = 0.26, p = 0.029) and FA (β = 0.30, p = 0.029), and higher BMI (β = 0.28, p = 0.046), independent from depression and PTSD symptoms. Conclusions: The findings indicate that, among Black individuals with predominantly low income in the U.S., perceived role in their community is associated with eating patterns and body mass. Given the small sample size, the results should be interpreted with caution.
The Art of Teaching English as a Foreign Language Teachers’ Perception of HOTS-Based Learning in EFL Classroom

This study examines the perception of English teachers towards HOTS-based Learning in EFL classroom. This study was a survey study with interview as the data collection technique. The participants of the study were five English teachers in senior high school in Singaraja, Buleleng, Bali. The result of data analysis found that teachers’ awareness of implementing HOTS-based instruction starting from lesson plan, teaching strategies that promote higher thinking and assessment. However, teachers also faced difficulties in developing HOTS-based Instructions such as limited knowledge and lack of training. It is suggested that English teachers broaden their knowledge on developing HOTS-based instruction and conduct a discussion with peers and experts. The role of principle is also essential in giving instructions and training towards HOTS-based learning instructions.
Applications of Current Density Functional Theory (DFT) Methods in Polymer Solar Cells

DFT and time-dependant DFT (TD-DFT) quantum chemical calculations have become helpful for qualitative and quantitative analyses of materials at the molecular level. In this paper, we will attempt to outline successes and opportunities associated with the use of DFT and TD-DFT in OSC research. Density functional theory (DFT) has evolved as a QM method that is both rigorous and efficient enough to be employed in photovoltaic solar cell challenges in the last ten years. DFT is a prominent method for precisely and efficiently calculating molecular systems’ electrical and optical characteristics at a low computational cost. The possible uses of DFT to polymer solar cells were comprehensively examined in this article. First, the foundations of DFT are examined. Following that, the precision of DFT for studying photovoltaic properties particular to polymer solar cell design is highlighted. Next, this chapter looks at how DFT is used in polymer solar cell research and its accuracy. Following that, a discussion of how DFT works and how it can investigate polymer solar cell features will be given.
Constrained Optimal Power Flow Considering Distributed Generations in power Systems

The operating costs of electric power systems can be minimized through the application of optimal power flow. In this paper, an interior point based optimization algorithm is implemented to solve the optimal power flow (OPF) problems with multiple objective functions. This algorithm takes into consideration Security Constrained Optimal Power Flow (SCOPF), which known as an extension of optimal power flow (OPF). SCOPF helps to maintain the combined goal of economy and security of the power system. The improvement in system performance is developed based on cost reduction of power generation and power loss. The obtained results from the proposed technique have been compared with other results reported in the literature. To validate the proposed approach, IEEE-30 bus system has been studied. لا صخلم : ثملا ةردقلا نايرس ةيبرهكلا ىوقلا مظنل ليغشتلا فيلاكت ضيفخت يف يساسأ لكشب مهاسي يل ، جذومن بسنأ يلإ لوصولل ادج ةريثك تايمزراوخ قيبطت مت دقو ليغشتلا فيلاكت ضيفخت ضرغب ةيبرهكلا ةردقلا نايرسل ، ةردقلا نايرسل لثملأا لحلل لوصولل ةيلخادلا ةطقنلا ةيمزراوخ قيبطت ثحبلا اذه مدقي ، قيبطت مت دقو نم نوكم ماظنل ةحرتقملا ةينقتلا 30 بيضق IEEE-30-bus دكأتلل لثملأا نايرسلا عم ناملأا تاقوعم ىلع زيكرتلا مت دقو . ةحرتقملا ةينقتلا قيبطت ىودج نم و ةقد ةصلختسملا جئاتنلا تتبثأ دقو ىرخا جئاتن عم ةصلختسملا جئاتنلا ةنراقم مت دقو . ةردقلل ةءافك ملأا تاقوعم يلإ لوصولل ةحرتقملا ةيمزراوخلا لحلا عم نا ةردقلا نايرسل لثملأا ، ا عم . ماظنلل هحومسملا دودحلا رابتع
Integrated Knowledge Elicitation and Representation Framework.

Abstract : This report summarizes the results of a project designed to develop methods to elicit and represent expert knowledge. Previous work in knowledge elicitation/engineering has been largely applications-driven, with expert knowledge force-fit into predefined knowledge frameworks. The goals of this project were to gain insight into how experts structure knowledge, to develop and test a set of integrated knowledge-elicitation techniques driven by this understanding of expert knowledge representation and use, and to gain insight into the nature of expertise and how it develops. Knowledge-elicitation sessions were conducted with some fifty experts in order of battle analysis, situation assessment, target development, and collection management at Forts Bragg, Carson, Lewis, Hood, and Huachuca. Results indicate that experts use a diverse range of knowledge structures depending on their functional area, level of experience, unit, and other variables. These structures are used integratively rather than singly. As a result, we propose an Integrated Knowledge Structure (INKS) framework for expert knowledge representation.