Miracle-dz/UniFAR-FTUs huggingface dataset:
Library involvement in health informatics education for health professions students and practitioners: a scoping review

Objective: The purpose of this scoping review is to evaluate the extent of library or librarian involvement in informatics education in the health domain. Methods: We searched eight databases from their inception to 2019 for reports of informatics educational activities for health professionals or health professions students that involved library staff or resources. Two reviewers independently screened all titles/abstracts (n=2,196) and resolved inclusion decisions by consensus. From the full text of the 36 papers that met the inclusion criteria, we extracted data on 41 educational activities. Results: The most frequent coded purposes of activities were “teaching clinical tools” (n=19, 46.3%) and “technology” (n=17; 41.5%). Medical students were the most frequent primary audience (34.1%), though 41.5% of activities had multiple audiences. Evaluation was reported for 24 activities (58.5%), only a few of which assessed short or post-activity impact on attitudes, knowledge, or skills. The most common long-term outcome was applying skills in other courses or clinical experiences. Thematic analysis yielded three areas of outcomes and issues for the library and organizational partners: expanded opportunities, technology and resource issues, and value demonstration. Conclusions: Limited published examples of health informatics educational activities provide models for library roles in informatics education. More librarians should report on their informatics educational activities and provide sufficient details on the interventions and their evaluation. This would strengthen the evidence base about the potential impact of libraries within informatics education.
Mental well-being and quality of working life in UK social workers before and during the COVID-19 pandemic: A propensity score matching study

Abstract During the COVID-19 pandemic interest into its potential impact on mental well-being has intensified. Within the social care sector, the pandemic has increased job demands and prolonged stress taking a disproportionate toll on the workforce, particularly social workers. This article compares the mental well-being and quality of working life of social workers in the United Kingdom (UK) before and during the pandemic. Data were collected in 2018 (N = 1,195) and 2020 (N = 1,024) using two cross-sectional surveys. To account for the differences between the datasets, propensity score matching was employed prior to effect estimation, utilising demographic and work-related variables common to both datasets. The differences between the two time-points were estimated using multiple regressions. Both mental well-being and quality of working life were significantly higher during the COVID-19 pandemic in 2020 compared to 2018. This suggests that during the highpoint of the pandemic in the UK, increased support, and changes to working practices, such as reprioritisation of work and other initiatives, may be responsible for increased mental well-being and quality of working life. While acknowledging the known pressures on UK social workers during the COVID-19 pandemic this evidence suggests a mixed picture of the pandemic with lessons for managers and employers.
The effect of age on the heart rate variability of healthy subjects

In this work we study the characteristics of heart rate variability (HRV) as a function of age and gender. Our analysis covers a wider age range than that studied so far. It includes results previously reported in the literature and reveals behaviours not reported before. We can establish basic scale relationships in different HRV measurements. The mean value of the RR intervals shows a power-law behaviour independent of gender. Magnitudes such as the standard deviation or pNN50 show abrupt changes at around the age of 12 years, and above that age they show gender dependence, which mainly affects short-time (or high frequency) scales. We present a unified analysis for the calculation of the non-linear α and β parameters. Both parameters depend on age; they increase in the extremes of life and reach a minimum at around one year of age. These gender-independent changes occur at low frequencies and in scale ranges that depend on age. The results obtained in this work are discussed in terms of the effects of basal metabolic rate, hormonal regulation, and neuronal activity on heart rate variability. This work finally discusses how these findings influence the interpretation of HRV measurements from records of different lengths.
Protective Effect of an Anti-HMGB-1 Neutralizing Antibody on Hemozoin-Induced Alveolar Epithelial Cell in a Model of Malaria Associated ALI/ARDS

Background: We aimed to determine whether neutralizing high mobility group box-1 (HMGB-1) prevents the release of HMGB-1 and proinflammatory cytokines on hemozoin (Hz)-induced alveolar epithelial cell in a model of malaria associated ALI/ARDS. Methods: This study was conducted in the Department of Tropical Pathology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand in 2020. Human pulmonary alveolar epithelial cells (HPAEpiCs) were exposed to medium alone or 20 μM Hz for 24 h and incubated with different concentrations (1, 5, and 10 μg/ml) of anti-HMGB-1 monoclonal antibody (mAb) for various times (0, 4, 12, 24, and 48 h). The levels of HMGB-1, TNF-α and IFN-γ in the supernatants were measured by ELISA. The mRNA expression of RAGE, TLR-2 and TLR-4 were analyzed by real-time PCR. Results: The HPAEpiCs treated with 10 μg/ml anti-HMGB-1 mAb showed a significant reduction in HMGB-1 release into the supernatant compared with those treated with 1 and 5 μg/ml anti-HMGB-1 mAb. The levels of TNF-α and IFN-γ were significantly decreased in the supernatant of HPAEpiCs treated with 1, 5, and 10 μg/ml anti-HMGB-1 mAb for 4, 12, 24, and 48 h compared with those stimulated with Hz alone. The mRNA expression levels of RAGE, TLR-2, and TLR-4 were significantly decreased after 24 h of anti-HMGB-1 antibody treatment at all concentrations. Conclusion: An anti-HMGB-1 antibody could be an effective agent for inhibiting the release of HMGB-1, TNF-α and IFN-γ. Furthermore, a neutralizing anti-HMGB-1 antibody could be applicable for the treatment of malaria-associated ALI/ARDS.
The long-term economic effects of pandemics: toward an evolutionary approach

Abstract COVID-19 has brought to the forefront of academic debates the consequences of pandemics and their appropriate policy responses. Using the PRISMA methodology, we provide a comprehensive review of the economic and historical analysis of the long-term economic consequences of pandemics. Mainstream economists focus on the impact of pandemics on production factors, finding a rich but contrasting set of mechanisms with overall negative or insignificant effects. Historians focus on the institutional impact, finding positive effects of pandemics when they trigger new socioeconomic arrangements. Evolutionary economists can integrate into the economic debate both historical elements and the complex biological characteristics of pandemics. We argue that the evolutionary approach provides new and fertile theoretical foundations to understand the phenomenon and develop effective policies.
Polyunsaturated fatty acids cause physiological and behavioral changes in Vibrio alginolyticus and Vibrio fischeri

Vibrio alginolyticus and Vibrio (Aliivibrio) fischeri are Gram‐negative bacteria found globally in marine environments. During the past decade, studies have shown that certain Gram‐negative bacteria, including Vibrio species (cholerae, parahaemolyticus, and vulnificus) are capable of using exogenous polyunsaturated fatty acids (PUFAs) to modify the phospholipids of their membrane. Moreover, exposure to exogenous PUFAs has been shown to affect certain phenotypes that are important factors of virulence. The purpose of this study was to investigate whether V. alginolyticus and V. fischeri are capable of responding to exogenous PUFAs by remodeling their membrane phospholipids and/or altering behaviors associated with virulence. Thin‐layer chromatography (TLC) analyses and ultra‐performance liquid chromatography‐electrospray ionization mass spectrometry (UPLC/ESI‐MS) confirmed incorporation of all PUFAs into membrane phosphatidylglycerol and phosphatidylethanolamine. Several growth phenotypes were identified when individual fatty acids were supplied in minimal media and as sole carbon sources. Interestingly, several PUFAs acids inhibited growth of V. fischeri. Significant alterations to membrane permeability were observed depending on fatty acid supplemented. Strikingly, arachidonic acid (20:4) reduced membrane permeability by approximately 35% in both V. alginolyticus and V. fischeri. Biofilm assays indicated that fatty acid influence was dependent on media composition and temperature. All fatty acids caused decreased swimming motility in V. alginolyticus, while only linoleic acid (18:2) significantly increased swimming motility in V. fischeri. In summary, exogenous fatty acids cause a variety of changes in V. alginolyticus and V. fischeri, thus adding these bacteria to a growing list of Gram‐negatives that exhibit versatility in fatty acid utilization and highlighting the potential for environmental PUFAs to influence phenotypes associated with planktonic, beneficial, and pathogenic associations.
The modeled distribution of corals and sponges surrounding the Salas y Gómez and Nazca ridges with implications for high seas conservation

The Salas y Gómez and Nazca ridges are two adjacent seamount chains off the west coast of South America that collectively contain more than 110 seamounts. The ridges support an exceptionally rich diversity of benthic and pelagic communities, with the highest level of endemism found in any marine environment. Despite some historical fishing in the region, the seamounts are relatively pristine and represent an excellent conservation opportunity to protect a global biodiversity hotspot before it is degraded. One obstacle to effective spatial management of the ridges is the scarcity of direct observations in deeper waters throughout the region and an accompanying understanding of the distribution of key taxa. Species distribution models are increasingly used tools to quantify the distributions of species in data-poor environments. Here, we focused on modeling the distribution of demosponges, glass sponges, and stony corals, three foundation taxa that support large assemblages of associated fauna through the creation of complex habitat structures. Models were constructed at a 1 km2 resolution using presence and pseudoabsence data, dissolved oxygen, nitrate, phosphate, silicate, aragonite saturation state, and several measures of seafloor topography. Highly suitable habitat for each taxa was predicted to occur throughout the Salas y Gómez and Nazca ridges, with the most suitable habitat occurring in small patches on large terrain features such as seamounts, guyots, ridges, and escarpments. Determining the spatial distribution of these three taxa is a critical first step towards supporting the improved spatial management of the region. While the total area of highly suitable habitat was small, our results showed that nearly all of the seamounts in this region provide suitable habitats for deep-water corals and sponges and should therefore be protected from exploitation using the best available conservation measures.
Influencing cell fate decisions using physical and chemical cues

Author(s): Sia, Junren | Advisor(s): Li, Song | Abstract: Directed genetic reprogramming of cells from one identity to another offers tremendous potential in regenerative medicine, disease modelling and drug testing. However, its application is limited by the low efficiency at which it occurs, and existing methods to improve efficiency mostly utilize additional molecular biology and biochemical manipulations. This thesis explored an alternative paradigm for improving reprogramming efficiency: presentation of physical cues. To this end, I first showed that simply agitating an adherent culture with an orbital shaker enhanced its efficiency of reprogramming to induced pluripotent stem cells (iPSCs). I further demonstrated that convective mixing of the culture medium by orbital agitation blunted the upregulation of CDK inhibitor p57/Kip2 that was caused by the culture becoming overconfluent, which in turn enhanced the efficiency of reprogramming to iPSCs. Next, I showed that culturing reprogramming cells on solid supports scored with microgrooves enhanced their reprogramming into cardiomyocytes. I demonstrated that the microgrooves caused upregulation of the activity of the transcription factor megakaryoblastic leukemia-1 (Mkl1) / myocardin-related transcription factor A (Mrtf-a) and also enhanced organization of sarcomeric structure, with both effects contributing to better reprogramming efficiency. In addition to physical cues, I also explored whether treatment with only small molecules could reprogram fibroblasts into skeletal muscle cells. Indeed, I found that an optimized basal medium (10% FBS in DMEM with 50 μg/ml of ascorbic acid and 50 ng/ml of basic fibroblast growth factor (bFGF)) containing just 2 small molecules— 616452 [an inhibitor of the protein kinase activity of the transforming growth factor-beta (TGF-β) type I receptor (R1)] and forskolin (a plant diterpene that stimulates adenylyl cyclase and elevates the intracellular level of 3',5'-cyclic-AMP)—was sufficient to achieve reprogramming at high efficiency. In summary, this thesis described how both physical and chemical cues can contribute to enhancing the reprogramming of cell identity.
Validation of conventional non-invasive fibrosis scoring systems in patients with metabolic associated fatty liver disease

BACKGROUND Non-invasive fibrosis scores are not yet validated in the newly defined metabolic associated fatty liver disease (MAFLD). AIM To evaluate the diagnostic performance of four non-invasive scores including aspartate aminotransferase to platelet ratio index (APRI), fibrosis-4 index (FIB-4), body mass index, aspartate aminotransferase/alanine aminotransferase ratio, diabetes score (BARD), and nonalcoholic fatty liver disease fibrosis score (NFS) in patients with MAFLD. METHODS Consecutive patients with histologically confirmed MAFLD were included. The discrimination ability of different non-invasive scores was compared. RESULTS A total of 417 patients were included; 156 (37.4%) of them had advanced fibrosis (Metavir ≥ F3). The area under receiver operating characteristic curve of FIB-4, NFS, APRI, and BARD for predicting advanced fibrosis was 0.736, 0.724, 0.671, and 0.609, respectively. The area under receiver operating characteristic curve of FIB-4 and NFS was similar (P = 0.523), while the difference between FIB-4 and APRI (P = 0.001) and FIB-4 and BARD (P < 0.001) was statistically significant. The best thresholds of FIB-4, NFS, APRI, and BARD for diagnosis of advanced fibrosis in MAFLD were 1.05, -2.1, 0.42, and 2. A subgroup analysis showed that FIB-4, APRI, and NFS performed worse in the pure MAFLD group than in the hepatitis B virus-MAFLD group. CONCLUSION APRI and BARD scores do not perform well in MAFLD. The FIB-4 and NFS could be more useful, but a new threshold is needed. Novel non-invasive scoring systems for fibrosis are required for MAFLD.
Multi-frequency ODMR of Nitrogen-Vacancy Color Centers in Diamond Crystals in zero magnetic fields

Techniques of optical detection of magnetic resonance, as applied tothe nitrogen-vacancy center in diamond, provide a tool for controlling both electron and nuclear spins. These techniques generally use a combination of microwave (MW) drive field for electronic spin transitions and radiofrequency (RF) drive field for nuclear spin transitions. They are most effective in strong magnetic fields where levels anticrossing (LAC) occurs; therefore NV spin system dynamics is mostly studied under these conditions. Nevertheless, zero-field LAC can probably also be used for controlling electron and nuclear spin states as well for exciting narrow resonances for metrological application, and these perspectives are not yet properly investigated. Here we present two-quantum resonances appearing in ODMR spectra of NV centers in bulk diamond under multi-frequency (MW+RF) resonance excitation in zero and ultra-low magnetic fields, and discuss their specifics.
Structural, morphological, composition and optical properties of undoped zinc oxide thin films prepared by spray pyrolysis method: effect of solution concentrations

Abstract The aim of this paper is the study of transparent undoped zinc oxide thin films obtained by spray pyrolysis technique on glass substrates heated at 350 °C from 0.1 to 0.4 mol solution concentrations using zinc acetate dehydrate as precursor. The X-ray diffraction patterns and Raman spectrometry with respect to Urbach energy and wurtzite structure, show that the maximum value of the high frequency intensity E2 and the optimal value of the optical gap are obtained at 0.2 mol concentration. Furthermore, an appropriate transparency is obtained and that makes these films suitable for photovoltaic windows layer cells.
Eurotium Cristatum Postfermentation of Fireweed and Apple Tree Leaf Herbal Teas

Fungi Eurotium spp. are the main biological agents that ferment the leaves of the Camellia sinensis tea bush to form a popular food product, postfermented tea. The fungus E. cristatum, stored in the collection of the Gause Institute of New Antibiotics under the number INA 01267, was isolated and identified from a briquette of Fujian Chinese tea. The species identification was carried out based on morphocultural characteristics and DNA sequencing. This study is aimed at determining the feasibility of making postfermented herbal teas using E. cristatum and to evaluate their quality. Autofermented herbal teas from Chamaenerion angustifolium (fireweed) and Malus domestica (apple tree) served as the starting material for this study. The change in the concentration of phenolic compounds, organic acids, sugars, and free amino acids was observed for herbal teas subjected to postfermentation with E. cristatum INA 01267. It was found that the E. cristatum INA 01267 strain does not have antimicrobial activity and does not form mycotoxins, which is an indicator of food safety.
Taste loss as a distinct symptom of COVID-19: A systematic review and meta-analysis

Chemosensory scientists have been skeptical that reports of COVID-19 taste loss are genuine, in part because, before COVID-19, taste loss was rare and often confused with smell loss. Therefore, to establish the predicted prevalence rate of taste loss in COVID-19 patients, we conducted a systematic review and meta-analysis of 376 papers published in 2020 and 2021, with 241 of the papers meeting all inclusion criteria. Additionally, we explored how methodological differences (direct vs. self-report measures) may affect these estimates. We hypothesized that direct prevalence measures of taste loss would be the most valid because they avoid the taste/smell confusion of self-report. The meta-analysis showed that, among 138,897 COVID-19-positive patients, 39.2% reported taste dysfunction (95% CI: 35.34-43.12%), and the prevalence estimates were slightly but not significantly higher from studies using direct (n = 18) versus self-report (n = 223) methodologies (Q = 0.57, df = 1, p = 0.45). Generally, males reported lower rates of taste loss than did females and taste loss was highest in middle-aged groups. Thus, taste loss is a bona fide symptom COVID-19, meriting further research into the most appropriate direct methods to measure it and its underlying mechanisms.
Traditional partería providing women's health care in Latin America: A qualitative synthesis.

AIM To identify practices, beliefs, and potential gaps in knowledge about partería tradicional in Latin America. BACKGROUND/INTRODUCTION Partería tradicional (lay midwifery) refers to ancestral knowledge used by laypersons, mainly parteras tradicionales (lay midwives), to provide health care to women and children. This care, initiated prior to formalization of health care continues today. Descriptions of the intergenerational oral transmission of partería tradicional knowledge and practice in Latin America exist without related synthesis. METHODS Qualitative synthesis of the literature, including publications in Spanish, English, and Portuguese indexed in public databases over the previous 22 years concerning partería tradicional. Identification of categories, themes, and bias reporting via PRISMA processes, using the Thomas and Harden's approach and the Noblit and Hare's methodological recommendations. RESULTS Partería tradicional themes included "ancestral knowledge," "destiny and a spiritual calling," "woma's heritage," and "a means for providing health care. " DISCUSSION Parteras tradicionales are key providers of health care for rural and urban marginalized communities. Limited knowledge and understanding of this practice impacts interactions between parteras tradicionales, midwives, and nurses. An interchange of knowledge is fundamental for care congruent with culture and the humanization of women's reproductive health. CONCLUSIONS AND POLICY IMPLICATIONS Communities with unresolved health care needs benefit via collaboration between formal health practices and partería tradicional. A compelling need for inquiry to preserve the art of partería tradicional exists internationally. Parteras tradicionales must be considered when formulating health care policy, thereby enhancing their historic role among the most vulnerable populations in Latin America: protecting, caring, and addressing health care needs.
Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies

These findings demonstrate that inhibition of PIM induces DLBLC cell death via MYC-dependent and -independent mechanisms and enhances the therapeutic response to anti-CD20 antibodies by increasing CD20 expression. The family of PIM serine/threonine kinases includes three highly conserved oncogenes, PIM1, PIM2, and PIM3, which regulate multiple prosurvival pathways and cooperate with other oncogenes such as MYC. Recent genomic CRISPR-Cas9 screens further highlighted oncogenic functions of PIMs in diffuse large B-cell lymphoma (DLBCL) cells, justifying the development of small-molecule PIM inhibitors and therapeutic targeting of PIM kinases in lymphomas. However, detailed consequences of PIM inhibition in DLBCL remain undefined. Using chemical and genetic PIM blockade, we comprehensively characterized PIM kinase–associated prosurvival functions in DLBCL and the mechanisms of PIM inhibition–induced toxicity. Treatment of DLBCL cells with SEL24/MEN1703, a pan-PIM inhibitor in clinical development, decreased BAD phosphorylation and cap-dependent protein translation, reduced MCL1 expression, and induced apoptosis. PIM kinases were tightly coexpressed with MYC in diagnostic DLBCL biopsies, and PIM inhibition in cell lines and patient-derived primary lymphoma cells decreased MYC levels as well as expression of multiple MYC-dependent genes, including PLK1. Chemical and genetic PIM inhibition upregulated surface CD20 levels in an MYC-dependent fashion. Consistently, MEN1703 and other clinically available pan-PIM inhibitors synergized with the anti-CD20 monoclonal antibody rituximab in vitro, increasing complement-dependent cytotoxicity and antibody-mediated phagocytosis. Combined treatment with PIM inhibitor and rituximab suppressed tumor growth in lymphoma xenografts more efficiently than either drug alone. Taken together, these results show that targeting PIM in DLBCL exhibits pleiotropic effects that combine direct cytotoxicity with potentiated susceptibility to anti-CD20 antibodies, justifying further clinical development of such combinatorial strategies. Significance: These findings demonstrate that inhibition of PIM induces DLBCL cell death via MYC-dependent and -independent mechanisms and enhances the therapeutic response to anti-CD20 antibodies by increasing CD20 expression.