Miracle-dz/UniFAR-FTUs huggingface dataset:
Development and Validation of RP-HPLC method for the Estimation of Ritonavir in API and tablet Formulation

A Reverse Phase High Performance Liquid Chromatographic method has been developed and validated for estimation of Ritonavir in API and Tablet formulation. The chromatographic separation was carried out using ZOROBAX Bonus-RP C-18 column (250 x 4.6mm, 5µm) as stationary phase and Methanol: Acetonitrile: 0.1% Trifluoroacetic acid water (81:9:10) as mobile phase at 1.0 ml/min flow rate and detection was carried out at 250 nm. The method was validated accordance to the Guidelines of International Council for Harmonization (ICH). Ritonavir have linearity in the concentration range of 50-150µg/ml with correlation coefficient (r2=1) respectively. Ritonavir eluted at 3.05 min respectively. The method is sensitive, precise and accurate. So, the method can be successfully applied for the routine analysis of Ritonavir in pharmaceutical formulations.
The intracellular negative regulator genes of the Wnt signaling in imatinib treatment

Aim: Tyrosine kinase inhibitors are a targeted and successful treatment modalities in the treatment of Chronic Myeloid Leukemia (CML). Imatinib mesylate is the most common of these inhibitors, but resistance reactions limit its use. It is believed that regulators in the Wnt signaling pathway play an important role in the treatment of CML. The aim of this study is to investigate possible expression changes of intracellular negative regulator genes after imatinib mesylate treatment in chronic myeloid leukemia cell line. Materials and Methods: Total RNA isolation was performed from K562 cells treated with Imatinib mesylate for 24 hours at 0.5 μM concentration and control native K562 cells. Following cDNA synthesis, expression changes of eight intracellular negative regulator genes were analyzed by Real-Time PCR. Results: When the results were evaluated, it was determined that the expression of 5 genes increased and the expression of 3 genes decreased in K562 cells treated with imatinib. Conclusion: When we suppressed Bcr-Abl with Imatinib in K562 cells, it was observed that there were changes in the expression levels of the intracellular negative regulator genes of the Wnt signaling pathway. These changes are important in defining new targets in CML treatment. To understand the roles of these negative regulators, it is important to conduct detailed research to develop new strategies for CML treatment.
Solid-State Structural Properties of Alloxazine Determined from Powder XRD Data in Conjunction with DFT-D Calculations and Solid-State NMR Spectroscopy: Unraveling the Tautomeric Identity and Pathways for Tautomeric Interconversion

We report the solid-state structural properties of alloxazine, a tricyclic ring system found in many biologically important molecules, with structure determination carried out directly from powder X-ray diffraction (XRD) data. As the crystal structures containing the alloxazine and isoalloxazine tautomers both give a high-quality fit to the powder XRD data in Rietveld refinement, other techniques are required to establish the tautomeric form in the solid state. In particular, high-resolution solid-state 15N NMR data support the presence of the alloxazine tautomer, based on comparison between isotropic chemical shifts in the experimental 15N NMR spectrum and the corresponding values calculated for the crystal structures containing the alloxazine and isoalloxazine tautomers. Furthermore, periodic DFT-D calculations at the PBE0-MBD level indicate that the crystal structure containing the alloxazine tautomer has significantly lower energy. We also report computational investigations of the interconversion between the tautomeric forms in the crystal structure via proton transfer along two intermolecular N–H···N hydrogen bonds; DFT-D calculations at the PBE0-MBD level indicate that the tautomeric interconversion is associated with a lower energy transition state for a mechanism involving concerted (rather than sequential) proton transfer along the two hydrogen bonds. However, based on the relative energies of the crystal structures containing the alloxazine and isoalloxazine tautomers, it is estimated that under conditions of thermal equilibrium at ambient temperature, more than 99.9% of the molecules in the crystal structure will exist as the alloxazine tautomer.
Controller design for a power factor correction regulator R 2 P 2

A controller is proposed for a switching regulator with a power factor correction (PFC) regulator. The controller uses the general PWM, which avoids the complicated control circuitry asociated to the multiplier approaches widely used in PFC. A systematic tuning procedure is derived for the PFC regulator, which is developed from the analysis of the non-linear closed-loop equations. The resulting controller is applied to a PFC regulator to achieve a high power factor. It is important to point out that the proposed PFC regulator is based on the reduced redundant power processing (R2P2) principle, which improves the efficiency.
Development Strategy of Gas Engines in China

Based on the analysis of the gas fuel resources, the development potential of gas engines in China is evaluated. And contribution of application of gas engines on the reduction of Green House Gas (GHG) emissions as well as harmful emissions is estimated. Since gas engines are different from conventional internal combustion engines on fuel system and combustion system, the key technologies relating to developing gas engines are introduced, and the major difficulties of popularizing of gas engines are discussed. With the foundation of the analysis, development strategy of gas engines is proposed.
A Lateration Method based on Effective Combinatorial Beacon Selection for Bluetooth Low Energy Indoor Positioning

Nowadays, the Bluetooth Low Energy (BLE) technology joined with the Received Signal Strength Indicator technique has became a popular approach in Indoor Positioning System, thanks to the wide availability of BLE in anchors and wearable devices and the straightforward implementation of both. Consequently, methods based on geometric properties of anchors, as lateration, are capable of enhancing the positioning accuracy exploiting the growing availability of anchors and their rich geometric distribution in indoor environments. On the downside, an inappropriate selection of anchors decreases the positioning accuracy estimation. Therefore, integrating an effective beacon selection method can enhance the reliability and accuracy of these methods. In this paper, we present a novel and straightforward Lateration indoor positioning method based on effective combinatorial BLE beacon selection. The combinatorial BLE selection approach relies on a geometrical analysis (difference of triangle areas), of each beacon combination, considering the reference beacons’ position with the estimated position using lateration, and with a globally calculated virtual target position as reference. The real-world experiment demonstrated that the proposed method improves the traditional lateration with 5% to 16%, considering different evaluation metrics.
Development of Data Infrastructure for the Long Term Bridge Performance Program

The growth of the National Bridge Inventory database, the availability of new data from embedded sensors, in-situ tests and live load tests together with additional bridge related data, e.g. geospatial and weather data, represents an immense source of information helpful for a better understanding of bridge performance and deterioration. However, in order to efficiently exploit this overwhelming amount of information a new generation of data management and data analysis tools is needed. In this paper we describe an open, scalable, and extensible data management and data analysis infrastructure which will be established within the framework of the Long Term Bridge Performance Program (LTBP). MOTIVATION Highway bridges play an important role in the national transportation network. Like any other infrastructure asset, bridges deteriorate with time and require regular maintenance to continue operating at an acceptable level. Often, funding constraints makes it impossible for the bridge owners to perform all maintenance activities that should be carried out at a given time, and they must face the difficult decision of selecting a small subset of maintenance activities that could be performed within available resources, while maximizing the return on investment. Making educated decisions on maintenance activities require bridge owners and other stakeholders to better understand bridge performance. More specifically, given the current condition of a bridge, owners must understand how each of the recommended maintenance activities may impact the overall bridge function, and which activities provide the best costbenefit tradeoff. However, understanding bridge performance is non-trivial and requires an indepth analysis of how bridges function and behave under various complex and interrelated factors and stresses, including but not limited to traffic volumes, overall load, weather conditions, environmental assaults, age, materials, design and prior maintenance history of the bridge.
Preparation of Electrospun Polyvinyl Alcohol/Nanocellulose Composite Film and Evaluation of Its Biomedical Performance

Using polyvinyl alcohol (PVA) and nanocellulose (NC) as raw materials, PVA/NC nanofiber membranes were prepared by electrospinning. The hydrogen bonding, crystalline properties and microscopic appearance of PVA/NC membranes with different NC contents were characterized. The mechanical properties, liquid absorption and cytotoxicity of the nanofiber membrane were evaluated. The results show that the free hydroxyl group of the PVA/NC nanofiber membranes have a maximum value of 9% at a mass fraction of 6% NC. The crystallinity of the PVA/NC nanofiber membranes and the average diameter of the nanofibers decreased and then increased as the NC content increased, with a minimum value of 38.23% and 272.03 nm, respectively, at 6% NC content. At this time, the contact angle was the smallest. The maximum strength of the PVA/NC nanofiber membranes is 75.8% higher than that of the PVA membrane at 2% NC content. With increasing NC content, the absorption of water, PBS sustained-release suspensions and artificial blood by PVA/NC nanofiber membranes increases. Cytotoxicity tests have shown that PVA/NC nanofiber membranes are non-toxic, have good cytocompatibility and are expected to be used in the field of medical dressings.
Book Review: STRUCTURAL HEALTH MONITORING WITH PIEZOELECTRIC WAFER ACTIVE SENSORS by VICTOR GIURGIUTIU - University of South Carolina © ELSEVIER - Academic Press, 2008, pp. 747

In this issue of the journal we have the opportunity to present an editorial brand, otherwise immediately retrievable with a simple search on Google (“the most comprehensive text/reference yet written on all aspects of Structural Health Monitoring”). Indeed, there are not many publishing houses that can compete with Elsevier, and the author is undoubtedly a reference name of a domain of growing interest.
An empirical examination of consumer CSR expectations: attribution, satisfaction, referral, and willingness to pay a premium

ABSTRACT This research employs the Expectancy Confirmation/Disconfirmation (ECD) paradigm to extend the knowledge about consumer response to CSR. While several scholars have identified consumer satisfaction with the firm as a salient variable that justifies investment in CSR, few have considered consumers’ CSR perceptions against the backdrop of their CSR expectations, and none has done so empirically. This research examines whether ECD, which incorporates perceptions and expectations regarding CSR, affects satisfaction, referral, and willingness to pay a premium. In addition to replicating prior findings of the interplay between the three outcome variables, our two empirical studies underscore (a) the pertinence of the ECD paradigm to CSR research; (b) the direct and indirect effects of ECD on satisfaction, referral, and willingness to pay a premium; and (c) the role of attribution and satisfaction as serial mediators. Theoretical and managerial implications are discussed, and research limitations are disclosed.
Investigation of Swirling Flow in Rod Bundle Subchannels Using Computational Fluid Dynamics

The fluid dynamics for turbulent flow through rod bundles representative of those used in pressurized water reactors is examined using computational fluid dynamics (CFD). The rod bundles of the pressurized water reactor examined in this study consist of a square array of parallel rods that are held on a constant pitch by support grids spaced axially along the rod bundle. Split-vane pair support grids are often used to create swirling flow in the rod bundle in an effort to improve the heat transfer characteristics for the rod bundle during both normal operating conditions and in accident condition scenarios. Computational fluid dynamics simulations for a two subchannel portion of the rod bundle were used to model the flow downstream of a split-vane pair support grid. A high quality computational mesh was used to investigate the choice of turbulence model appropriate for the complex swirling flow in the rod bundle subchannels. Results document a central swirling flow structure in each of the subchannels downstream of the split-vane pairs. Strong lateral flows along the surface of the rods, as well as impingement regions of lateral flow on the rods are documented. In addition, regions of lateral flow separation and low axial velocity are documented next to the rods. Results of the CFD are compared to experimental particle image velocimetry (PIV) measurements documenting the lateral flow structures downstream of the split-vane pairs. Good agreement is found between the computational simulation and experimental measurements for locations close to the support grid.Copyright © 2006 by ASME
Stress analysis of normal and osteoarthritic femur using finite element analysis

Stress distribution within the normal and osteoarthritic femur is studied using plane stress finite element analysis. During the progress of osteoarthritis of hip, the resultant load transferred from the acetabulum to the femur, instead of acting over a large area is reduced considerably. Also, the resultant load changes its direction becoming more vertical in advanced stages of the disease. This alters the stress distribution within the femur. Regions of extremely low stresses are observed at the outer layers of the femur head which may cause the bone to atrophy resulting in void formation. As a follow up, we have modelled these voids as stress raisers. Subsequent analysis reveal stress concentration in the immediate neighbourhood of the voids suggesting these areas as potential sites for microfractures which may eventually lead to femoral neck fractures.
Classification of sea-ice images using a dual-polarized radar

The classification of the returns of a ship-borne like- and cross-polarized radar system into one of four categories, first-year ice, multilayer ice, icebergs, and shadows cast by icebergs is described. The data sets are digitized images obtained from a dual-polarized noncoherent Ku-band (16.5-GHz) radar used on the northern tip of Baffin Island, Canada. By using both the like- and cross-polarized radar inputs, classifier accuracy is improved compared to previous classifiers using only a single input. In particular, the use of both polarizations significantly improves the discrimination between icebergs and multilayer ice. In order to combine the like- and cross-polarized inputs, four classifiers are used: a one-dimensional classifier using the composite image formed by fusing the two polarization inputs with principal components analysis; a two-dimensional Gaussian classifier; and two neural network classifiers (the multilayer perceptron and the Kohonen feature map classifier). The results are compared to the classification based on a single like- or cross-polarized input. >
Immune-based combinations for metastatic triple negative breast cancer in clinical trials: current knowledge and therapeutic prospects

ABSTRACT Introduction Immune checkpoint inhibitor (ICI) monotherapy appears to be effective in a small cohort of patients with metastatic triple negative breast cancer (mTNBC). This supports the exploration of strategies for increasing the efficacy of immunotherapy. To enhance overall response and clinical outcomes, several immune-based combinations are being investigated. Areas covered The authors present a synopsis of current, state-of-art immune-based combinations in this setting and reflect on future possibilities. They shed light on recently presented and published clinical trials and ongoing studies. A literature search was conducted in October 2021; in addition, abstracts of international cancer meetings were reviewed. Expert opinion Clinical trials suggest that ICI monotherapy could be beneficial in a minority of mTNBC patients; conversely, several immune-based combinations have reported notable results in recently presented or published studies. Some of these combination strategies have been approved for mTNBC – as in the case of chemoimmunotherapy in PD-L1 positive patients. Numerous trials are investigating novel ICI-based combinations and their results are eagerly awaited.
Positive output cascade boost converters

The voltage lift technique has been successfully employed in the design of DC/DC converters, e.g. three-series Luo-converters, in which the output voltage increases stage-by-stage in arithmetic progression. The super-lift technique considerably increases the voltage transfer stage-by-stage gain in geometric progression. However, their circuits are complex. An approach, positive output cascade boost converters, that implements the output voltage increasing in geometric progression with a simple structure is introduced. These converters also effectively enhance the voltage transfer gain in power-law terms.
NUMERICAL SOLVING OF BALLISTIC FLIGHT EQUATIONS FOR BIG BORE AIR RIFLE

kalibra, punj plinom. Balističke jednadžbe otpor zrakom ispunjenog prostora pri izračunu rezultata. Danas postoje balistički programi na tržištu, koji su bazirani na modelu. Zračna puška velikog kalibra koristi kuglu kao projektil, i brzine projektila su uglavnom manje od brzine zvuka. se mogu koristiti pojednostavnjeni modeli za brzo izračunavanje balističkih putanja i brz ene s ugljik-dioksid (CO ) koriste raznovrsni komplicirani komercijalni "modified point mass – MPMM" modelu, ili pak na "6 Degrees of Freedom" Stoga ina projektila. 2
Band-Mott mixing hybridizes the gap in 
Fe2Mo3O8

K. Park, 2 G. L. Pascut, 3 G. Khanal, M. O. Yokosuk, Xianghan Xu, Bin Gao, M. J. Gutmann, A. P. Litvinchuk, V. Kiryukhin, 8 S. -W. Cheong, 8, 9 D. Vanderbilt, K. Haule, and J. L. Musfeldt 10, ∗ These authors contributed equally to this work Department of Chemistry, University of Tennessee, Knoxville, Tennessee 37996, USA MANSiD Research Center and Faculty of Forestry, Applied Ecology Laboratory, Stefan Cel Mare University (USV), 13 University Rd, Suceava 720229, Romania Department of Physics and Astronomy, Rutgers University, Piscataway, New Jersey 08854, USA Department of Physics and Astronomy, Rice University, Houston, Texas 77005, USA ISIS Facility, STFC-Rutherford Appleton Laboratory, Didcot OX11 OQX, United Kingdom Texas Center for Superconductivity and Department of Physics, University of Houston, Houston, Texas 77204, USA Rutgers Center for Emergent Materials, Rutgers University, Piscataway, New Jersey 08854, USA Laboratory for Pohang Emergent Materials and Max Planck POSTECH Center for Complex Phase Materials, Pohang University of Science and Technology, Pohang 790-784, Korea Department of Physics and Astronomy, University of Tennessee, Knoxville, Tennessee 37996, USA (Dated: March 7, 2022)
Design of compact dual-band bandpass filter using dual-mode stepped-impedance stub resonators

A dual-band bandpass filter (BPF) using a novel stepped-impedance stub resonator (SISR) is presented. The proposed SISR is found to have the advantage that the even-mode resonant frequencies can be flexibly controlled, whereas the odd-mode resonant frequencies are fixed. Based on the proposed SISR, a dual-band filter is implemented by tuning its geometric parameters. To improve the selectivity, a filter with four transmission zeros on either side of both passbands is designed by introducing a 0° feeding structure. A prototype of a dual-band BPF centred at 1.84 and 2.65 GHz has been designed and fabricated. The measured results validate the full-wave EM simulated results.
Planarization optimization of RF-MEMS switches with a gold membrane

In this paper, a new process is analysed to improve the contact area between a metallic bridge and a signal line of a capacitive switch thanks to a better membrane planarization. Two planarization methods are investigated: thermal process with hard-bake steps and chemical mechanical polishing planarization. Moreover, two different sacrificial layers are used: polyimide (PMGI) and photoresist (AZ1529). For each sacrificial layer and planarization method, the influence of planarity and roughness on down-state capacitance is evaluated. Results show that down-state capacitance is more sensitive to flatness than roughness. Moreover PMGI is the best sacrificial layer to improve down-state capacitance mainly for high resonance frequency switches due to capacitance surface reduction.
Coping the Recession

The UK economy has suffered through two deep recessions over the last decade and, as a consequence, its productive structure has undergone a major transformation. The most visible consequences of these events include two waves of large scale job shedding (with profoundly different regional impacts) accompanied by persistently high unemployment throughout the 1980s and early-1990s. This time period has also seen steeply rising small and large firm failure rates, a major reshuffling in the ownership of many businesses, severe imbalances between the supply of and demand for certain types of skills exacerbated by regional immobilities in labour, a crisis of consumer confidence coupled with a reluctance by consumers to take on (or add to) their long-term debt, and a general decline in the authority and confidence with which demand management policies have been pursued.
An Improved KSVD Algorithm for Ground Target Recognition Using Carrier-Free UWB Radar

The carrier-free ultra-wideband (UWB) radar (impulse radar) has seen a recent surge of interest. In this letter, a novel recognition system for vehicles based on the carrier-free UWB radar is proposed, in which the sparse representation is introduced as an effective feature extraction method. Based on the original K-SVD algorithm, we provide a new dictionary learning (DL) idea. Instead of only embedding discrimination criteria in the objective function, we expand and improve the optimization procedure of the K-SVD algorithm. Moreover, to alleviate the impact of the signal diversity on the recognition performance, we propose a hierarchical code constraint (HCC) and bind it to the improved K-SVD model. In this way, signals from the same class but with different distributions will be represented by the corresponding dictionary atoms. Extensive experiments prove the improved K-SVD with an HCC-IKSVD can effectively take both reconstruction capability and discriminative power of the dictionary into consideration.