Miracle-dz/UniFAR-FTUs huggingface dataset:
Brazilian Guidelines for Early Mobilization in Intensive Care Unit

Immobility can cause several complications, including skeletal muscle atrophy and weakness, that influence the recovery of critically ill patients. This effect can be mitigated by early mobilization. Six key questions guided this research: Is early mobilization safe? Which patients are candidates for early mobilization? What are the contraindications? What is the appropriate dose, and how should it be defined? What results are obtained? What are the prognostic indicators for the use of early mobilization? The objective of this guideline was to produce a document that would provide evidence-based recommendations and suggestions regarding the early mobilization of critically ill adult patients, with the aim of improving understanding of the topic and making a positive impact on patient care. This guideline was based on a systematic review of articles conducted using the PICO search strategy, as recommended by the Guidelines Project of the Associação Médica Brasileira. Randomized clinical trials, prognostic cohort studies, and systematic reviews with or without meta-analysis were selected, and the evidence was classified according to the Oxford Center for Evidence-based Medicine Levels of Evidence. For all the questions addressed, enough evidence was found to support safe and well-defined early mobilization, with prognostic indicators that support and recommend the technique. Early mobilization is associated with better functional outcomes and should be performed whenever indicated. Early mobilization is safe and should be the goal of the entire multidisciplinary team.
USING LINKED DATA TECHNOLOGIES

Semantic Web encourages digital libraries, including open access journals, to collect, link and share their data across the Web in order to ease its processing by machines and humans to get better queries and results. Linked Data technologies enable connecting related data across the Web using the principles and recommendations set out by Tim Berners-Lee in 2006. Several universities develop knowledge through scholarship and research with open access policies for the generated knowledge, using several ways to disseminate information. Open access journals collect, preserve and publish scientific information in digital form related to a particular academic discipline in a peer review process having a big potential for exchanging and spreading their data linked to external resources using Linked Data technologies. Linked Data can increase those benefits with better queries about the resources and their relationships. This paper reports a process for publishing scientific data on the Web using Linked Data technologies. Furthermore, methodological guidelines are presented with related activities. The proposed process was applied extracting data from a university Open Journal System and publishing in a SPARQL endpoint using the open source edition of OpenLink Virtuoso. In this process, the use of open standards facilitates the creation, development and exploitation of knowledge.
Protective role of cardiac-specific overexpression of caveolin-3 in cirrhotic cardiomyopathy.

BACKGROUND Cirrhotic cardiomyopathy is a clinical syndrome in patients with liver cirrhosis characterized by blunted cardiac contractile responses to stress and/or heart rate-corrected QT (QTc) interval prolongation. Caveolin-3 (Cav-3) plays a critical role in cardiac protection and is an emerging therapeutic target for heart disease. We investigated the protective role of cardiac-specific overexpression (OE) of Cav-3 in cirrhotic cardiomyopathy. METHODS Biliary fibrosis was induced in male Cav-3 OE mice and transgene negative (TGneg) littermates by feeding a diet containing 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC, 0.1%) for 3 weeks. Liver pathology and blood chemistries were assessed, and stress echocardiography, telemetry, and isolated heart perfusion studies to assess adrenergic responsiveness were performed. RESULTS Cav-3 OE mice showed a similar degree of hyperdynamic contractility, pulmonary hypertension, and QTc interval prolongation as TGneg mice after 3 weeks of DDC diet. Blunted systolic responses were shown in both DDC-fed Cav-3 OE and TGneg hearts after in vivo isoproterenol challenge. However, QTc interval prolongation after in vivo isoproterenol challenge was significantly less in DDC-fed Cav-3 OE hearts compared to DDC-fed TGneg hearts. In ex vivo perfused hearts, where circulatory factors are absent, isoproterenol challenge showed hearts from DDC-fed Cav-3 OE mice had better cardiac contractility and relaxation compared to DDC-fed TGneg hearts. CONCLUSIONS Although Cav-3 OE in the heart did not prevent cardiac alterations in DDC-induced biliary fibrosis, cardiac expression of Cav-3 reduced QTc interval prolongation after adrenergic stimulation in cirrhosis.
NEAR-OPTIMAL DISTRIBUTED MAXIMUM FLOW \ast

We present a near-optimal distributed algorithm for (1 + o(1))-approximation of single-commodity maximum flow in undirected weighted networks that runs in (D + \surd n) \cdot no(1) communication rounds in the CONGEST model. Here, n and D denote the number of nodes and the network diameter, respectively. This is the first improvement over the trivial bound of O(n2), and it nearly matches the \~ \Omega (D+ \surd n)-round complexity lower bound. The development of the algorithm entails two subresults of independent interest: (i) A (D+ \surd n) \cdot no(1)-round distributed construction of a spanning tree of average stretch no(1). (ii) A (D + \surd n) \cdot no(1)-round distributed construction of an no(1)-congestion approximator consisting of the cuts induced by O(logn) virtual trees. The distributed representation of the cut approximator allows for evaluation in (D + \surd n) \cdot no(1) rounds. All our algorithms make use of randomization and succeed with high probability.
Evaluation of Microbiological, Physicochemical, and Sensory Properties of Galbi-jjim Prepared by Sous-vide and Cookchill Method at Different Temperatures

The aim of this study was to evaluate the physico-chemical, sensory, and microbiological properties of ready-to-eat Korean traditional seasoned beef ribs (“galbi-jjim”) prepared by sous-vide/cookchill technology during storage at three different temperatures (4, 10, and 20 C). Beef short ribs marinated in soy sauce for 24 h at 3 C were packed with vegetables under vacuum. Vacuum-packed beef ribs mixed with vegetables were heated at 90 C for 90 min in a water bath, and then immediately chilled below 3 C within 120 min in an ice slurry. Physicochemical (pH, water activity, TBARS, L*a*b* color, and texture profile), sensory (appearance, odor, flavor, texture, and acceptance) and microbiological (Coliform, Escherichia coli, food-borne pathogenic bacteria) properties of the samples were determined during storage at different temperatures. Results showed that pH, a , and sensory evaluation of products were not affected in any consistent way as a function of either storage duration or temperature. Coliform, E. coli and food-borne pathogens were not detected during storage at any temperature. However, TBARS significantly increased during storage period (p<0.05). Based on TBARS values, SV/CC “galbi-jjim” can be stored for 15 d, 12 d and 1 d at 4, 10 and 20 C, respectively.
Education in Thailand

A modern educational system had not been offi cially established in Thailand until the 1870s. Before that time, the family ("ban"), the temple ("wat"), and the King's palace ("wang") were the three institutions re sponsible for the education of Thai children. The fami ly gave nonformal learning and training, basically, on agricultural skills and social skills. The temples pro vided boys with the basic three R's in order that they could understand Buddhist principles. The King's palace provided another kind of education more or less of a manpower oriented approach, with special interest in training young government officials.
Oxytocin receptor signalling modulates novelty recognition but not social preference in zebrafish

Sociality is a complex phenomenon that involves the individual´s motivation to approach their conspecifics, along with social cognitive functions that enable individuals to interact and survive. The nonapeptide oxytocin (OXT) is known to regulate sociality in many species. However, the role of OXT in specific aspects of sociality is still not well understood. In the present study, we investigated the contribution of the OXT receptor (OXTR) signalling in two different aspects of zebrafish social behaviour: social preference, by measuring their motivation to approach a shoal of conspecifics, and social recognition, by measuring their ability to discriminate between a novel and familiar fish, using a mutant zebrafish lacking a functional OXTR. Although oxtr mutant zebrafish displayed normal attraction to a shoal of conspecifics, they exhibited reduced social recognition. We further investigated whether this effect would be social‐domain specific by replacing conspecific fish by objects. Although no differences were observed in object approach, oxtr mutant fish also exhibited impaired object recognition. Our findings suggest that OXTR signalling regulates a more general memory recognition of familiar vs novel entities, not only in social but also in a non‐social domain, in zebrafish.
The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History

With the incidence of sleeping sickness in decline and genuine progress being made towards the WHO goal of eliminating sleeping sickness as a major public health concern, this is a good moment to evaluate the drugs that ‘got the job done’: their development, their limitations and the resistance that the parasites developed against them. This retrospective looks back on the remarkable story of chemotherapy against trypanosomiasis, a story that goes back to the very origins and conception of chemotherapy in the first years of the 20 century and is still not finished today.
Ecological plasticity, neophobia, and resource use in birds

Determining the mechanisms that underlie ecological plasticity should be an important focus of avian behavioral ecology. Most attempts to model the responses of birds to changes in food distribution and abundance of potential competitors are based on the assumption that different species sample and track resources in an equivalent manner. However, differences in how readily birds respond to novel resources are difficult to model and may be impossible to predict based on strictly economic approaches. Most observers of wild birds have noted intrinsic differences within and between species in “ecological plasticity,” or the tendency to exploit new resources. Furthermore, it has been proposed that the degree of plasticity influences a species’ colonizing ability and, ultimately, the probability that it can give rise to other species occupying new adaptive zones. I propose that variation in plasticity is a direct result of variation in neophobia: the fear of feeding on new foods or approaching new situations. This provides natural selection with the raw material for adjusting adaptive levels of neophobia. Where ecological plasticity is favored, selection could act to reduce neophobia.
Runaway Youth: Caring for the Nation’s Largest Segment of Missing Children

The largest segment of missing children in the United States includes runaways, children who run away from home, and thrownaways, children who are told to leave or stay away from home by a household adult. Although estimates vary, as many as 1 in 20 youth run away from home annually. These unaccompanied youth have unique health needs, including high rates of trauma, mental illness, substance use, pregnancy, and sexually transmitted infections. While away, youth who run away are at high risk for additional trauma, victimization, and violence. Runaway and thrownaway youth have high unmet health care needs and limited access to care. Several populations are at particular high risk for runaway episodes, including victims of abuse and neglect; lesbian, gay, bisexual, transgender, and questioning youth; and youth in protective custody. Pediatricians and other health care professionals have a critical role to play in supporting runaway youth, addressing their unique health needs, fostering positive relationships within their families and with other supportive adults, and connecting them with available community resources. This report provides clinical guidance for pediatricians and other health care professionals regarding (1) the identification of adolescents who are at risk for running away or being thrown away and (2) the management of the unique medical, mental health, and social needs of these youth. In partnership with national, state, and local resources, pediatricians can significantly reduce risk and improve long-term outcomes for runaway youth.
Bioinspired Artificial Tobacco Mosaic Virus with Combined Oncolytic Properties to Completely Destroy Multidrug‐Resistant Cancer

Although biomimetic virus‐like strategies have been widely used in antitumor applications, construction of uniquely shaped virus‐like agents and optimization of their specific morphological features to achieve diverse antitumor functions are worthwhile pursuits. Here, a novel strategy to construct an artificial tobacco mosaic virus (ATMV) that closely mimics the structure of the rod‐like tobacco mosaic virus (TMV) is developed. The supramolecular array is self‐assembled from small, repeated subunits of tailor‐made capsid‐mimicking dendrons onto RGD‐modified single‐walled carbon nanotube to construct the ATMVs with high structural stability. The ATMVs are tactfully designed with shielding, targeting, and arming approaches, including shielding the viruses against premature elimination, selectively targeting tumor tissue, and arming the viruses with oncolytic abilities. The elongated particles are concealed in blood until they arrived at a tumor site, then they induce robust composite oncolytic processes including cytomembrane penetration, endoplasmic reticulum disruption to cause Ca2+ release, chemotherapeutic delivery, and photothermal therapy. Excitingly, the ATMVs not only lyse primary infected cells, but permeate adjacent cells for secondary infection, spreading cell‐to‐cell and continuing to induce lysis even deep in solid tumors. This work inspires a uniquely shaped virus‐like agent with tactically optimized oncolytic functions that completely defeated large drug‐resistant colon tumor (LoVo/Adr, ≈500 mm3).
Genetic privacy and the use of archival human material in genetic studies – current perspectives

License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress. com/permissions.php Medicolegal and Bioethics 2015:5 43–52 Medicolegal and Bioethics Dovepress
Older Adults’ Views on the Repositioning of Primary and Community Care

ABSTRACT Older adults are rarely consulted on health care restructuring. To address this gap, our study explored older adults’ views on “repositioning”, a restructuring initiative to support independent living for older adults with complex chronic disease (CCD). We collected and analysed data from 83 older adults living in one small city and nine rural small towns where “repositioning” of primary and community care was occurring. Average participant age was 75 years; 56 (67%) were women, 44 (53%) had CCD, and 20 (24%) identified as Indigenous or South Asian. The four themes were: unfamiliarity with repositioning; optimism versus skepticism; improving primary and community care (through better home care, improved transportation, and more doctors); and, playing an active role to effect change. For repositioning to be successful, diverse service users must be fully included; rural-dwelling older adults’ priorities for primary and community care need to be addressed, rather than using a “cookie-cutter” approach.
G protein α subunit suppresses sporangium formation through a serine/threonine protein kinase in Phytophthora sojae

Eukaryotic heterotrimeric guanine nucleotide-binding proteins consist of α, β, and γ subunits, which act as molecular switches to regulate a number of fundamental cellular processes. In the oomycete pathogen Phytophthora sojae, the sole G protein α subunit (Gα; encoded by PsGPA1) has been found to be involved in zoospore mobility and virulence, but how it functions remains unclear. In this study, we show that the Gα subunit PsGPA1 directly interacts with PsYPK1, a serine/threonine protein kinase that consists of an N-terminal region with unknown function and a C-terminal region with a conserved catalytic kinase domain. We generated knockout and knockout-complemented strains of PsYPK1 and found that deletion of PsYPK1 resulted in a pronounced reduction in the production of sporangia and oospores, in mycelial growth on nutrient poor medium, and in virulence. PsYPK1 exhibits a cytoplasmic-nuclear localization pattern that is essential for sporangium formation and virulence of P. sojae. Interestingly, PsGPA1 overexpression was found to prevent nuclear localization of PsYPK1 by exclusively binding to the N-terminal region of PsYPK1, therefore accounting for its negative role in sporangium formation. Our data demonstrate that PsGPA1 negatively regulates sporangium formation by repressing the nuclear localization of its downstream kinase PsYPK1.
Influence of Annealing on the Damping Behavior of Ni-Cu-Mn-Ga Ferromagnetic Shape Memory Alloys

Damping materials have attracted much attention for wide potential applications in the industry. Previous research shows that annealing treatment is an effective and costless way of improving the functional properties of conventional shape memory alloys. However, there are few investigations concerning the annealing effect of the ambient-temperature damping behavior. In this paper, we present the influence of annealing treatment on the martensitic transformation and damping behaviors of Ni55−xCuxMn25Ga20 (x = 0, 2, 4, 6) alloys within the ambient-temperature range. With increasing annealing time, the martensitic transformation temperature and the temperature span of martensitic transformation decrease. Moreover, annealing treatment greatly enhances the twin boundary damping peak of martensite. The X-ray diffraction (XRD) measurement demonstrates that annealing can improve the degree of L21 atomic order, which relieves the pinning effects for the twin boundary motion and thus leads to the enhancement of the twin boundary damping of these alloys.
Relationship of Serum Progesterone and Progesterone Metabolites with Mammographic Breast Density and Terminal Ductal Lobular Unit Involution among Women Undergoing Diagnostic Breast Biopsy

The association of progesterone/progesterone metabolites with elevated mammographic breast density (MBD) and delayed age-related terminal duct lobular unit (TDLU) involution, strong breast cancer risk factors, has received limited attention. Using a reliable liquid chromatography-tandem mass-spectrometry assay, we quantified serum progesterone/progesterone metabolites and explored cross-sectional relationships with MBD and TDLU involution among women, ages 40–65, undergoing diagnostic breast biopsy. Quantitative MBD measures were estimated in pre-biopsy digital mammograms. TDLU involution was quantified in diagnostic biopsies. Adjusted partial correlations and trends across MBD/TDLU categories were calculated. Pregnenolone was positively associated with percent MBD-area (MBD-A, rho: 0.30; p-trend = 0.01) among premenopausal luteal phase women. Progesterone tended to be positively associated with percent MBD-A among luteal phase (rho: 0.26; p-trend = 0.07) and postmenopausal (rho: 0.17; p-trend = 0.04) women. Consistent with experimental data, implicating an elevated 5α-pregnanes/3α-dihydroprogesterone (5αP/3αHP) metabolite ratio in breast cancer, higher 5αP/3αHP was associated with elevated percent MBD-A among luteal phase (rho: 0.29; p-trend = 0.08), but not postmenopausal women. This exploratory analysis provided some evidence that endogenous progesterone and progesterone metabolites might be correlated with MBD, a strong breast cancer risk factor, in both pre- and postmenopausal women undergoing breast biopsy. Additional studies are needed to understand the role of progesterone/progesterone metabolites in breast tissue composition and breast cancer risk.
Specific Heat and Transport Functions of Water

Numerous water characteristics are essentially ascribed to its peculiarity to form strong hydrogen bonds that become progressively more stable on decreasing the temperature. However, the structural and dynamical implications of the molecular rearrangement are still subject of debate and intense studies. In this work, we observe that the thermodynamic characteristics of liquid water are strictly connected to its dynamic characteristics. In particular, we compare the thermal behaviour of the isobaric specific heat of water, measured in different confinement conditions at atmospheric pressure (and evaluated by means of theoretical studies) with its configurational contribution obtained from the values of the measured self-diffusion coefficient through the use of the Adam–Gibbs approach. Our results confirm the existence of a maximum in the specific heat of water at about 225 K and indicate that especially at low temperature the configurational contributions to the entropy are dominant.
Does the Site of Origin of the Microcarcinoma with Respect to the Thyroid Surface Matter? A Multicenter Pathologic and Clinical Study for Risk Stratification

It is unclear whether the site of origin of papillary thyroid microcarcinoma (mPTC) with respect to the thyroid surface has an influence on clinicopathologic parameters. The objectives of the study were to: (i) Accurately measure the mPTC distance from the thyroid surface; (ii) analyze whether this distance correlates with relevant clinicopathologic parameters; and (iii) investigate the impact of the site of origin of the mPTC on risk stratification. Clinicopathologic features and BRAF mutational status were analyzed and correlated with the site of origin of the mPTC in a multicenter cohort of 298 mPTCs from six Italian medical institutions. Tumors arise at a median distance of 3.5 mm below the surface of the thyroid gland. Statistical analysis identified four distinct clusters. Group A, mPTC: size ≥ 5 mm and distance of the edge of the tumor from the thyroid capsule = 0 mm; group B, mPTC: size ≥ 5 mm and distance of the edge of the tumor from the thyroid capsule > 0 mm; group C, mPTC: size < 5 mm and distance of the edge of the tumor from the thyroid capsule = 0 mm; and group D, mPTC: size < 5 mm and distance of the edge of the tumor from the thyroid capsule > 0 mm. Univariate analysis demonstrates significant differences between the groups: Group A shows the most aggressive features, and group D the most indolent ones. By multivariate analysis, group A tumors are characterized by tall cell histotype, BRAF V600E mutation, tumor fibrosis, aggressive growth with invasive features, vascular invasion, lymph node metastases, and intermediate ATA risk. The mPTC clinicopathologic features vary according to the tumor size and distance from the thyroid surface. A four-group model may be useful for risk stratification and to refine the selection of nodules to be targeted for fine needle aspiration.