Miracle-dz/UniFAR-FTUs huggingface dataset:
Deep Rating and Review Neural Network for Item Recommendation

To alleviate the sparsity issue, many recommender systems have been proposed to consider the review text as the auxiliary information to improve the recommendation quality. Despite success, they only use the ratings as the ground truth for error backpropagation. However, the rating information can only indicate the users’ overall preference for the items, while the review text contains rich information about the users’ preferences and the attributes of the items. In real life, reviews with the same rating may have completely opposite semantic information. If only the ratings are used for error backpropagation, the latent factors of these reviews will tend to be consistent, resulting in the loss of a large amount of review information. In this article, we propose a novel deep model termed deep rating and review neural network (DRRNN) for recommendation. Specifically, compared with the existing models that adopt the review text as the auxiliary information, DRRNN additionally considers both the target rating and target review of the given user–item pair as ground truth for error backpropagation in the training stage. Therefore, we can keep more semantic information of the reviews while making rating predictions. Extensive experiments on four publicly available datasets demonstrate the effectiveness of the proposed DRRNN model in terms of rating prediction.
A deep transfer learning framework for the automated assessment of corneal inflammation on in vivo confocal microscopy images

Purpose Infiltration of activated dendritic cells and inflammatory cells in cornea represents an important marker for defining corneal inflammation. Deep transfer learning has presented a promising potential and is gaining more importance in computer assisted diagnosis. This study aimed to develop deep transfer learning models for automatic detection of activated dendritic cells and inflammatory cells using in vivo confocal microscopy images. Methods A total of 3453 images was used to train the models. External validation was performed on an independent test set of 558 images. A ground-truth label was assigned to each image by a panel of cornea specialists. We constructed a deep transfer learning network that consisted of a pre-trained network and an adaptation layer. In this work, five pre-trained networks were considered, namely VGG-16, ResNet-101, Inception V3, Xception, and Inception-ResNet V2. The performance of each transfer network was evaluated by calculating the area under the curve (AUC) of receiver operating characteristic, accuracy, sensitivity, specificity, and G mean. Results The best performance was achieved by Inception-ResNet V2 transfer model. In the validation set, the best transfer system achieved an AUC of 0.9646 (P<0.001) in identifying activated dendritic cells (accuracy, 0.9319; sensitivity, 0.8171; specificity, 0.9517; and G mean, 0.8872), and 0.9901 (P<0.001) in identifying inflammatory cells (accuracy, 0.9767; sensitivity, 0.9174; specificity, 0.9931; and G mean, 0.9545). Conclusions The deep transfer learning models provide a completely automated analysis of corneal inflammatory cellular components with high accuracy. The implementation of such models would greatly benefit the management of corneal diseases and reduce workloads for ophthalmologists.
A Data-Driven Functional Mapping of the Anterior Temporal Lobes

Although the anterior temporal lobe (ATL) comprises several anatomic and functional subdivisions, it is often reduced to a homogeneous theoretical entity, such as a domain-general convergence zone, or “hub,” for semantic information. Methodological limitations are largely to blame for the imprecise mapping of function to structure in the ATL. There are two major obstacles to using fMRI to identify the precise functional organization of the ATL: the difficult choice of stimuli and tasks to activate, and dissociate, specific regions within the ATL; and poor signal quality because of magnetic field distortions near the sinuses. To circumvent these difficulties, we developed a data-driven parcellation routine using resting-state fMRI data (24 females, 64 males) acquired using a sequence that was optimized to enhance signal in the ATL. Focusing on patterns of functional connectivity between each ATL voxel and the rest of the brain, we found that the ATL comprises at least 34 distinct functional parcels that are arranged into bands along the lateral and ventral cortical surfaces, extending from the posterior temporal lobes into the temporal poles. In addition, the anterior region of the fusiform gyrus, most often cited as the location of the semantic hub, was found to be part of a domain-specific network associated with face and social processing, rather than a domain-general semantic hub. These findings offer a fine-grained functional map of the ATL and offer an initial step toward using more precise language to describe the locations of functional responses in this heterogeneous region of human cortex. SIGNIFICANCE STATEMENT The functional role of the anterior aspects of the temporal lobes (ATL) is a contentious issue. While it is likely that different regions within the ATL subserve unique cognitive functions, most studies revert to vaguely referring to particular functional regions as “the ATL,” and, thus, the mapping of function to anatomy remains unclear. We used resting-state fMRI connectivity patterns between the ATL and the rest of the brain to reveal that the ATL comprises at least 34 distinct functional parcels that are organized into a three-level functional hierarchy. These results provide a detailed functional map of the anterior temporal lobes that can guide future research on how distinct regions within the ATL support diverse cognitive functions.
Quantitative 3D Characterization of Nanoporous Gold Nanoparticles by Transmission Electron Microscopy

Abstract Quantitative structural characterization of nanomaterials is important to tailor their functional properties. Corrosion of AgAu-alloy nanoparticles (NPs) results in porous structures, making them interesting for applications especially in the fields of catalysis and surface-enhanced Raman spectroscopy. For the present report, structures of dealloyed NPs were reconstructed three-dimensionally using scanning transmission electron microscopy tomography. These reconstructions were evaluated quantitatively, revealing structural information such as pore size, porosity, specific surface area, and tortuosity. Results show significant differences compared to the structure of dealloyed bulk samples and can be used as input for simulations of diffusion or mass transport processes, for example, in catalytic applications.
Bayesian single‐arm phase II trial designs with time‐to‐event endpoints

For the cancer clinical trials with immunotherapy and molecularly targeted therapy, time‐to‐event endpoint is often a desired endpoint. In this paper, we present an event‐driven approach for Bayesian one‐stage and two‐stage single‐arm phase II trial designs. Two versions of Bayesian one‐stage designs were proposed with executable algorithms and meanwhile, we also develop theoretical relationships between the frequentist and Bayesian designs. These findings help investigators who want to design a trial using Bayesian approach have an explicit understanding of how the frequentist properties can be achieved. Moreover, the proposed Bayesian designs using the exact posterior distributions accommodate the single‐arm phase II trials with small sample sizes. We also proposed an optimal two‐stage approach, which can be regarded as an extension of Simon's two‐stage design with the time‐to‐event endpoint. Comprehensive simulations were conducted to explore the frequentist properties of the proposed Bayesian designs and an R package BayesDesign can be assessed via R CRAN for convenient use of the proposed methods.
Regular exercise stimulates endothelium autophagy via IL‐1 signaling in ApoE deficient mice

Regular exercise maintains arterial endothelial cell homeostasis and protects the arteries from vascular disease, such as peripheral artery disease and atherosclerosis. Autophagy, which is a cellular process that degrades misfolded or aggregate proteins and damaged organelles, plays an important role in maintaining organ and cellular homeostasis. However, it is unknown whether regular exercise stimulates autophagy in aorta endothelial cells of mice prone to atherosclerosis independently of their circulating lipid profile. Here, we observed that 16 weeks of voluntary exercise reduced high‐fat diet‐induced atherosclerotic plaque formation in the aortic root of ApoE deficient mice, and that this protection occurred without changes in circulating triglycerides, total cholesterol, and lipoproteins. Immunofluorescence analysis indicated that voluntary exercise increased levels of the autophagy protein LC3 in aortic endothelial cells. Interestingly, human umbilical vein endothelial cells (HUVECs) exposed to serum from voluntarily exercised mice displayed significantly increased LC3‐I and LC3‐II protein levels. Analysis of circulating cytokines demonstrated that voluntary exercise caused changes directly relevant to IL‐1 signaling (ie, decreased interleukin‐1 receptor antagonist [IL‐1ra] while also increasing IL‐1α). HUVECs exposed to IL‐1α and IL‐1β recombinant protein significantly increased LC3 mRNA expression, LC3‐I and LC3‐II protein levels, and autophagy flux. Collectively, these results suggest that regular exercise protects arteries from ApoE deficient mice against atherosclerosis at least in part by stimulating endothelial cell autophagy via enhanced IL‐1 signaling.
Well‐being in the time of COVID‐19: Do metaphors and mindsets matter?

Communications about the Coronavirus Disease 2019 (COVID‐19) often employ metaphors, which can help people understand complex issues. For example, public health messages may focus on “fighting” the disease, attempting to rouse people to action by instilling a sense of urgency. In contrast, change‐focused metaphors may foster growth mindsets and self‐efficacy—cornerstones of well‐being and action. We randomly assigned participants to read one of two articles—either an article about coronavirus that focused on fighting the war or an article that highlighted the possibility of change. In Study 1 (N = 426), participants who read the war, relative to the change, message reported lower growth mindsets and self‐efficacy and these in turn, predicted lower well‐being and weaker intentions to engage in health behaviours. In Study 2, (N = 702), we sought to replicate findings and included a no treatment control. We failed to replicate the effects of message condition, although both messages predicted greater self‐efficacy compared to the control. Similar to Study 1, growth mindsets predicted intentions to engage in recommended health behaviours and self‐efficacy predicted both well‐being and action. We discuss theoretical reasons for discrepancies as well as practical applications for developing public health communications.
Modification of small ubiquitin‐related modifier 2 (SUMO2) by phosphoubiquitin in HEK293T cells

Additional complexity in the post‐translational modification of proteins by ubiquitin is achieved by ubiquitin phosphorylation, for example within PINK1‐parkin mediated mitophagy. We performed a preliminary proteomic analysis to identify proteins differentially modified by ubiquitin in HEK293T, compared to phosphomimetic ubiquitin (Ser65Asp), and identified small ubiquitin‐related modifier 2 (SUMO2) as a candidate. By transfecting SUMO2 and its C‐terminal–GG deletion mutant, along with phosphomimetic ubiquitin, we confirm that ubiquitin modifies SUMO2, rather than vice versa. Further investigations revealed that transfected SUMO2 can also be conjugated by endogenous phospho‐Ser65‐(poly)ubiquitin in HEK293T cells, pointing to a previously unappreciated level of complexity in SUMO2 modification, and that unanchored (substrate‐free) polyubiquitin chains may also be subject to phosphorylation.
RELATE—a randomised controlled feasibility trial of a Relating Therapy module for distressing auditory verbal hallucinations: a study protocol

Introduction Auditory verbal hallucinations (AVHs) are associated with distress and reduced functioning. Research suggests that distress is associated with the voice hearer’s responding to AVH in a passive and subordinate manner. A novel approach focuses on relating to AVH and teaches assertive responses to AVH using experiential role-plays. A small pilot study found a large effect of this approach on AVH distress but an independent multicentre study is required to ascertain effectiveness across different settings. We aim to estimate the expected effect for a subsequent trial to demonstrate that adding a module of Relating Therapy (RT) to treatment as usual (TAU) is superior to TAU alone in reducing AVH distress. We also test the feasibility of patient recruitment, therapist training, and therapy monitoring in different psychological and psychiatric outpatient facilities in Germany. Methods and analysis We will recruit 75 patients diagnosed with a schizophrenia spectrum disorder and persistent distressing AVH across four sites. Patients will be randomised to receive either 16 sessions of RT plus TAU or TAU alone within a 5-month period. Randomisation will be stratified by sites. Single-blind assessments will take place at baseline, at 5 months (T1) and at 9 months (T2). The primary outcome is the distress factor score of the AVH subscale of the Psychotic Symptoms Rating Scale at T2 adjusted for the baseline value. Secondary outcomes are change in depressive symptoms, quality of life, time spent in structured activities as well as negative relating to voices and to other people. Ethics and dissemination The trial has received ethical approval from the German Psychological Society Ethics Committee. The trial results will be disseminated through conference presentations, peer-reviewed publications and social media. Trial registration number ClinicalTrials.gov Registry (NCT04578314).
The development of respect in young athletes: A systematic review and meta-analysis

Background The practice of sports can lead to the development of values such as respect, self-control, effort, autonomy and leadership. However, sport can only foster educational habits and values if it is properly timed and specifically focused towards that end. The aim of this study was to carry out a systematic review and meta-analysis of the effect of interventions on the development and promotion of respect in the practice of sport among young people. Methods A systematic search was conducted, according to the guidelines of the PRISMA declaration, in the Web of Science (WOS), PubMed (Medline), Scopus, Google Scholar and SportDiscus databases. A total of 6 articles were considered to meet the inclusion criteria for the promotion of respect. Criteria for inclusion included: the full text needed to be available; it should be written in one of the selected languages: English, Spanish and Portuguese; it should be an intervention, an experimental or quasi-experimental study or a randomized controlled trial. Each manuscript was independently reviewed by three authors of this work. Results The results of the meta-analyses showed that the Siedentop sports education model, and Hellison’s personal and social responsibility model (TPRS), had significant improvements regarding respect for opponents (total effect size = 0.39, small effect, with 95% Confidence Interval of 0.07 to 0.72). In addition, these models, along with another programme called Fair Play, also achieved significant increases as regards respect for the social conventions of sport (total effect size = 0.67, moderate effect, with 95% IC from 0.25 to 1.10). Conclusions In conclusion, the use of interventions related to the above-mentioned models is recommended when it is intended to encourage respect for opponents and social conventions. These considerations could be useful to both teachers and coaches in order to further cultivate these important attitudes.
Evaluation of psychological resilience and anxiety levels of patients with hyperemesis gravidarum diagnosis and comparison with healthy pregnant women

Objective: To compare the psychological resilience and anxiety levels of patients diagnosed with hyperemesis gravidarum (HG) and healthy pregnant women. Materials and Methods: A sociodemographic data form and the Resilience scale for Adults (RSA) and the State-Trait Anxiety Inventory (STAI) were administered. The sociodemographic data form was completed by the physician, and the RSA and STAI were completed by the participant. The sample of the study consisted of 60 pregnant women with HG and hospitalized and 97 healthy voluntary pregnant women with similar characteristics to the research group without any pregnancy complications. Data were evaluated using descriptive statistical analyses, the independent samples t-test, the Mann-Whitney U test and Pearson’s correlation analysis. Results: The age range was 18-42 years for HG group and 20-43 years for control group. The average age of the HG group was 28.17±5.96 years and that of the control group was 29.45±5.83 years. There was no statistically significant difference between the groups in terms of pregnancy week. Regarding the prevalence of state and trait anxiety between the groups, it was found that 66.7% of the HG group had a high level of trait anxiety and 51.7% had a high level of state anxiety. It was found that 61.9% of the control group had a high level of trait anxiety and 38.1% had a high level of state anxiety. There was no difference between the healthy pregnant group and the HG group in terms of anxiety (p=0.125). It was found that there was a significant difference between the groups in terms of only sub-dimensions of RSA, which were perception of self (U=2385.00, p=0.044) and perception of future (U=2350.50, p=0.030). The perception of self and perception of future scores of the healthy control group were higher. Conclusion: There was no difference between the healthy pregnant group and the HG group in terms of anxiety. It was observed that the HG group had a lower perception of self and future. Apart from the usual increase in anxiety levels during pregnancy, HG accompanied by stubborn nausea and vomiting does not create an extra psychological burden, either as a cause or a result.
Reducing occupational distress in veterinary medicine personnel with acceptance and commitment training: a pilot study

ABSTRACT Aims To determine whether an educational programme targeting the reaction of veterinary personnel to difficult client interactions reduced burden transfer, stress and burnout in veterinary staff. Methods Employees of three small-animal veterinary hospitals in the south-western United States of America were recruited and randomised to intervention (educational programme; n = 16) or control (no intervention; n = 18) groups. Participants of this randomised, parallel arms trial completed pre-programme assessment including the Burden Transfer Inventory (BTI), Perceived Stress Scale, and Copenhagen Burnout Inventory. Assessment was followed by two, group-format educational sessions, based on acceptance and commitment training, tailored to reducing reactivity to difficult veterinary client interactions (intervention group only). After training was completed, both groups were assessed using the same measures and the intervention participants provided use and acceptability ratings. Results Intervention participants rated the programme as useful and appropriate, and reported that programme techniques were used a median of 43 (min 9, max 68) times during the 2 weeks prior to retesting. Relative to pre-programme scores, median post-programme scores for reaction (subscore of BTI) to difficult client interactions decreased in the intervention group (33 vs. 54; p = 0.047), but not in the control group (51 vs. 59; p = 0.210). Changes in median scores for stress and burnout from pre- to post-programme were non-significant for both groups. Conclusions This pilot and feasibility trial showed high rates of acceptability and use by participants, as well as promising reductions in burden transfer. A larger scale clinical trial with follow-up at extended time points is needed to more fully examine the efficacy of this novel programme. Clinical relevance Preliminary findings suggest this programme may be a useful approach to reducing occupational distress for individuals working in veterinary practice.
A Virtual Reality Resident Training Curriculum on Behavioral Health Anticipatory Guidance: Development and Usability Study

Background Behavioral health disorders have steadily increased and been exacerbated by the COVID-19 pandemic. Though behavioral health disorders can be successfully mitigated with early implementation of evidence-based parent management strategies, education for pediatric residents on behavioral health anticipatory guidance has been limited to date, with training challenges compounded by the physical distancing requirements of the COVID-19 pandemic. Virtual reality (VR) simulations provide an opportunity to train residents on this complex competency by allowing deliberate practice of necessary skills while adhering to current social distancing guidelines. Objective This study explored the usability of a VR-based behavioral health anticipatory guidance curriculum for pediatric residents. Methods This mixed methods study included 14 postgraduate third-year pediatric residents who completed the behavioral health anticipatory guidance VR curriculum. Residents completed the MEC Spatial Presence Questionnaire to assess immersion in the virtual environment. Semistructured interviews were used to elucidate residents’ perspectives on the curriculum’s content and format. The interviews were analyzed using conventional content analysis. Results Quantitatively, residents reported a high degree of immersion, spatial presence, and cognitive involvement. Most residents (11/14, 79%) agreed or strongly agreed that it seemed as though they took part in the action of the simulation. Qualitatively, two themes emerged from the data: (1) the curriculum expands behavioral health anticipatory guidance and motivational interviewing knowledge and skills and (2) VR technology is uniquely positioned to develop competence. These themes revealed that the curriculum expanded their current level of knowledge and skill, addressed training gaps, and was applicable to all residents. Additionally, residents experienced VR as immersive, feasible, realistic to the clinic setting, and a safe space to practice and learn new skills. Conclusions Pilot data indicates that VR may be an effective tool to teach pediatric residents behavioral health anticipatory guidance, meeting a current gap in medical education training. This VR curriculum is particularly relevant in the context of the COVID-19 pandemic given the increased behavioral health concerns of families.