Miracle-dz/UniFAR-FTUs huggingface dataset:
The Structure and Dynamics of the Early-Type Resonance Ring Galaxy IC 4214. I. Observations

The southern galaxy IC 4214 is a bright, nearby example of a multiple ring early-type spiral galaxy with a weak bar. The galaxy shows three strong pseudoring features, including a nuclear ring, an inner ring, and a prominent R outer ring, each with distinctive characteristics. The galaxy is important because it is a classic resonance ring galaxy where the ring features can be linked to specific orbital resonances with the bar. We present in this paper a detailed UBVIH study of its photometric structure and a Fabry-Perot study of its kinematics to set the stage for a dynamical model in a separate paper. Despite the early Hubble type, ionized gas is well distributed in the inner disk regions, providing a well-sampled velocity field. Rapid rotation is found in the vicinity of the nuclear ring, where the rotation curve reaches a maximum, and the rotation velocities drop off somewhat with increasing radius in the outer regions. Noncircular motions are clearly seen in the observed velocity field. Analysis of both the velocity field and the shapes of isophotes give discrepant values for the inclination of the system, ranging from 47° to 50° from photometry to 55° to 58° from kinematics. A likely value of the inclination could be 52° if the inner and outer rings are intrinsically elongated and aligned perpendicular to each other.
Aberrant Expressions of Co-stimulatory and Co-inhibitory Molecules in Autoimmune Diseases

Co-signaling molecules include co-stimulatory and co-inhibitory molecules and play important roles in modulating immune responses. The roles of co-signaling molecules in autoimmune diseases have not been clearly defined. We assessed the expressions of co-stimulatory and co-inhibitory molecules in autoimmune diseases through a bioinformatics-based study. By using datasets of whole-genome transcriptome, the expressions of 54 co-stimulatory or co-inhibitory genes in common autoimmune diseases were analyzed using Robust rank aggregation (RRA) method. Nineteen array datasets and 6 RNA-seq datasets were included in the RRA discovery study and RRA validation study, respectively. Significant genes were further validated in several autoimmune diseases including Graves' disease (GD). RRA discovery study suggested that CD160 was the most significant gene aberrantly expressed in autoimmune diseases (Adjusted P = 5.9E-12), followed by CD58 (Adjusted P = 5.7E-06) and CD244 (Adjusted P = 9.5E-05). RRA validation study also identified CD160 as the most significant gene aberrantly expressed in autoimmune diseases (Adjusted P = 5.9E-09). We further found that the aberrant expression of CD160 was statistically significant in multiple autoimmune diseases including GD (P < 0.05), and CD160 had a moderate role in diagnosing those autoimmune diseases. Flow cytometry confirmed that CD160 was differentially expressed on the surface of CD8+ T cells between GD patients and healthy controls (P = 0.002), which proved the aberrant expression of CD160 in GD at the protein level. This study suggests that CD160 is the most significant co-signaling gene aberrantly expressed in autoimmune diseases. Treatment strategy targeting CD160-related pathway may be promising for the therapy of autoimmune diseases.
Are You Talking about Software Product Lines?: An Analysis of Developer Communities

Community-question-answering systems, such as Stack Overflow, provide a platform for various communities to ask questions, discuss topics, and find knowledge. Especially software developers are heavily relying on such systems to identify solutions for their problems. While the content of community-question-answering systems may be less scientific, it usually represents practical knowledge from various perspectives and backgrounds. Thus, analyzing this content can be valuable for the scientific community to understand previous and current (i.e., open questions) needs of practitioners. In this paper, we report a systematic analysis of two websites that comprise communities with a focus on software development: Stack Exchange and Quora. We extract questions, answers, comments, and discussions on software product lines in general and feature modeling in particular. The results provide a historical perspective, an overview on commonly addressed scopes, and a classification of discussed topics and problems. Moreover, our findings are interesting to understand the practical impact of software-product-line techniques outside of well-analyzed case studies, to support lectures by identifying regularly asked questions, and to scope tool development based on reported technical problems.
Molecular microbial ecology of lignocellulose mobilisation as a carbon source in mine drainage wastewater treatment.

The community structure of complex microbial consortia which develop in lignocellulose packed passive treatment systems for acid mine drainage remediation were investigated. An understanding of interactions between these populations is important in determining mechanisms by which such systems operate. A degrading packed bed reactor was packed with lignocellulositic material as a sole carbon source and fed continuously with simulated acid mine drainage. Samples were collected every two months at different depths of the reactor to isolate the total genomic DNA and PCR amplify section of 16S rDNA gene. PCR primers, GM5F and 907R incorporating GC clamp were used to amplify 586-bp region of 16S rDNA gene. Denaturing gradient gel electrophoresis (DGGE) indicated clearly a highly differentiated pattern of r-DNA – derived amplificates between different depths of the bioreactor. Predominant DGGE bands were further excised, reamplified, cloned and sequenced. Sequencing analysis revealed phylogenetic affiliation of specific bacterial populations in different depths of the bioreactor. Water SA Vol. 30 (5) 2005: pp.658-661
VLT/SPHERE astrometric confirmation and orbital analysis of the brown dwarf companion HR 2562 B

Context. A low-mass brown dwarf has recently been imaged around HR 2562 (HD 50571), a star hosting a debris disk resolved in the far infrared. Interestingly, the companion location is compatible with an orbit coplanar with the disk and interior to the debris belt. This feature makes the system a valuable laboratory to analyze the formation of substellar companions in a circumstellar disk and potential disk-companion dynamical interactions. Aims. We aim to further characterize the orbital motion of HR 2562 B and its interactions with the host star debris disk. Methods. We performed a monitoring of the system over ~10 months in 2016 and 2017 with the VLT/SPHERE exoplanet imager. Results. We confirm that the companion is comoving with the star and detect for the first time an orbital motion at high significance, with a current orbital motion projected in the plane of the sky of 25 mas (~0.85 au) per year. No orbital curvature is seen in the measurements. An orbital fit of the SPHERE and literature astrometry of the companion without priors on the orbital plane clearly indicates that its orbit is (quasi-)coplanar with the disk. To further constrain the other orbital parameters, we used empirical laws for a companion chaotic zone validated by N-body simulations to test the orbital solutions that are compatible with the estimated disk cavity size. Non-zero eccentricities (>0.15) are allowed for orbital periods shorter than 100 yr, while only moderate eccentricities up to ~0.3 for orbital periods longer than 200 yr are compatible with the disk observations. A comparison of synthetic Herschel images to the real data does not allow us to constrain the upper eccentricity of the companion.
UvA-DARE ( Digital Academic Repository ) Combinatorial RNAi against HIV-1

RNAi-based gene therapy is a powerful approach to treat viral infections because of its high efficiency and sequence-specificity. The HIV-1 based lentiviral vector system is suitable for the delivery of RNAi inducers to HIV-1 susceptible cells due to its potency to transduce non-dividing cells, including hematopoietic stem cells, and its ability for stable transgene delivery into the host cell genome. The presence of antiviral shRNA and miRNA cassettes can negatively affect the lentiviral vector titers, which was tested for antiHIV-1 shRNAs and miRNAs. We show that shRNAs that target the vector genomic RNA strongly reduced lentiviral vector titers, but inhibition of the RNAi pathway via saturation could rescue vector production. The presence of miRNAs in the vector RNA genome (sense orientation) results in a minor titer reduction due to Drosha processing. Vectors with the miRNAs in the antisense orientation have significant reduced titers due to self-targeting of the fully complementary vector target sequence by the mature miRNA. Another major cause for titer reduction of miRNA-vectors is likely due to promoter interference. The use of inducible promoters for expression of miRNA is therefore highly recommended. These results are important for further development and clinical application of lentiviral vectors encoding RNAi inducers.
ICFLSB: An Improved Collaborative Filtering Algorithm based on Latent Semantic and Bayesian

In the process of user-based collaborative filtering algorithm, finding similar users effectively plays a crucial role in obtaining a high recommendation accuracy. The original rating matrix is very sparse, resulting in similarity information loss during similarity calculating and degrading the efficiency of similar users extracting. To tackle this problem, we propose an improved collaborative filtering algorithm based on Latent Semantic and Bayesian (ICFLSB). ICFLSB first utilizes Latent Semantic to extract meaningful features in the original rating matrix. Then, we establish a Bayesian model based on these extracted features to predict items which users have not rated but may be interested. Further, we fill the sparse original rating matrix with these predicted items and find similar users. After that, we adopt the collaborative filtering algorithm to conduct recommendations. Experiments show that ICFLSB proposed in this paper has a better recommendation performance than the traditional collaborative filtering algorithm. In particular, the evaluation results demonstrate that our ICFLSB can achieve a 2.152% higher and 1.152% higher on recommendation accuracy and recall rate respectively when compared to the traditional collaborative filtering algorithm.
The performance of modal filtering in passive and active integrated antenna measurements at 160 GHz

The results of integrated antenna measurements are often severely distorted by reflections from the measurement environment. In order to contact and feed passive integrated antennas wafer probes have to be used. Wafer probes are not only electrically large, but are also located in the immediate environment of the antenna under test (AUT) and reflect parts of the radiated signals. This causes significant distortions and erroneous results in radiation pattern, directivity, and gain measurements. Custom wafer probes have been used to reduce reflections for meaningful measurement results, but these special probes are difficult to fabricate and expensive. If the antenna is measured within an active system that generates the transmit signal, waver probes are not required to feed the AUT, but bond wires, circuit elements close to the antenna, and surface wave radiation still limit the achievable accuracy of the measurements. In this paper modal filtering is used to mitigate the influence of unwanted distortions in post-processing for both wafer probe and active antenna measurements. It is shown that modal filtering can be applied to integrated antenna measurements above 100 GHz and that reflections from wafer probes, bond wires, and the PCB can be reduced significantly for passive and active antenna measurements, respectively.
Quality of life at six months after primary percutaneous coronary intervention performed at a predominantly rural population

Background: HRQL is important in improving the quality of patient care. However, there is a paucity of data from low-income and middle-income countries (LMIC). Differences in socio-demographics and socio-cultural contexts may influence HRQOL. Therefore, this research was designed with the aim to explore the HRQOL in patients after Percutaneous Coronary Intervention (PCI). Objective: The goal of the study was to evaluate the quality of life after six months of Percutaneous Coronary Intervention using HeartQol questionnaire at a tertiary care hospital in Pakistan.Method: This was a Cross-sectional, descriptive study. Patients between the ages of 20-60 years who underwent primary Percutaneous Coronary Intervention at least 6 months ago were inducted in the study. Coronary angiography was performed mostly through radial as preferred route. Data was collected using a structured questionnaire covering demographic characteristics, predisposing risk factors, procedural details, and quality of life. Heart related Quality of life was assessed using HeartQol questionnaire. Collected data was analyzed using SPSS v.21. Results: A total of 241 patients participated in the study. Mean age of the patients was 53.37±11.07 years. On analysis of quality of life at six months, the median (IQR) HeartQol score was 31 (37-23) with majority of the patients, 84.22% (203) fall under the excellent score (>20). Conclusion: It is of enormous prognostic importance that the quality of life of patient is assessed on a regular basis after PCI. Our study shows that the majority of patients had improved quality of life at six months of PCI. Majority of patients were not bothered by mild symptoms. Further investigation needs to be done to validate these results.
Signal jamming in the translation market and the complementary roles of certification and diplomas in developing multilateral signaling mechanisms

The market for translation services provided by individuals is currently characterized by significant uncertainty because buyers lack clear ways to identify qualified providers from amongst the total pool of translators. Certification and educational diplomas both serve to reduce the resulting information asymmetry, but both suffer from potential drawbacks: translator training programs are currently oversupplying the market with graduates who may lack the specific skills needed in the market and no certification program enjoys universal recognition. In addition, the two may be seen as competing means of establishing qualification. The resulting situation, in which potential clients are uncertain about which signal to trust, is known as a signal jam . In order to overcome this jam and provide more consistent signaling, translator-training programs and professional associations offering certification need to collaborate more closely to harmonize their requirements and deliver continuing professional development (CPD) that help align the outcomes from training and certification.
Communicating Museum Collections Information Online

Cultural heritage institutions are spending considerable effort and resources to provide online access to their collection catalogues and collection management systems, usually through their institutional websites. This improves accessibility and supports research and engagement by diverse user groups, as well as meeting the increasing expectation by audiences that this type of information will be freely and easily available online. However, cultural organisations have not responded to these needs in the same way and have been employing different web tools and features to present their collections online. In this article, we argue that the technological implementation choices and the type of content provided reflect also the philosophy of communication of the institution itself. We used the constructivist approach's learning theory and theory of knowledge and combined these interrelated epistemological and cognitive perspectives to analyse the communication philosophy of a large number of museum online catalogues. The article presents the research carried out initially in 2007 through 2009 and then again in 2017, studying the provision of collections information online by different types of museums across Europe and in the United States. This enabled us to establish categories of presentation types and study the changes over time. The results highlighted the major shift towards participatory practices which have been transforming the cultural heritage world over the past years.
Universality for generalized Wigner matrices with Bernoulli distribution

The universality for the eigenvalue spacing statistics of generalized Wigner matrices was established in our previous work \cite{EYY} under certain conditions on the probability distributions of the matrix elements. A major class of probability measures excluded in \cite{EYY} are the Bernoulli measures. In this paper, we extend the universality result of \cite{EYY} to include the Bernoulli measures so that the only restrictions on the probability distributions of the matrix elements are the subexponential decay and the normalization condition that the variances in each row sum up to one. The new ingredient is a strong local semicircle law which improves the error estimate on the Stieltjes transform of the empirical measure of the eigenvalues from the order $(N \eta)^{-1/2}$ to $(N \eta)^{-1}$. Here $\eta$ is the imaginary part of the spectral parameter in the definition of the Stieltjes transform and $N$ is the size of the matrix.
A cold globule with a Class 0/I embedded source

Infrared observations of the dark cloud DC 303.8-14.2 and the embedded point source IRAS 13036-7644 have been made with the ISOPHOT instrument aboard ISO at 7.7 μm, 60 μm, 100 μm and 200 μm. We have compared the properties of dust in DC 303.8-14.2 and the Thumbprint Nebula (TPN), a morphologically similar globule but without star formation. The dust temperature at the center of DC 303.8-14.2 has a minimum of 14.6 ± 1 K, similar to that in the TPN. A comparison of far-infrared radial optical depth distributions between these clouds at angular scales of ∼1.5'-3' shows no difference. The observations suggest that there is a bright rim of 7,7 μm emission that peaks just outside the,optical bright rim of the cloud, indicating a halo of very small dust particles or PAHs around the cloud. The bolometric luminosity of the IRAS source is estimated to be about 1.0 L ○. The heating of the cloud by the IRAS source is negligible; the thermal structure of the cloud is dominated by external heating. We have studied the evolutionary status of the IRAS source and find it to be located between Class 0 and Class I, at a late accretion phase. The source was detected at 7.7 μm and we suggest that this emission is due to the 7.7 μm UIR band. We also give a compilation of small molecular clouds whose extended FIR emission has been mapped with ISO.
Reasonable Evaluation Model of Pediatric Disease Based on pharmacology and Data Mining

With the growing medical technology and many major achievements, the research on the laws of common diseases in pediatrics is also developing rapidly. The resulting drug data has increased exponentially, forming a large number of common disease medication data. So much data contains a lot of information with important scientific value. Therefore, the discovery of the pathogenic sites of pediatric diseases has positive significance for the prevention and treatment of human life and health. The main purpose of the research is to establish a reasonable evaluation model based on pediatric disease pharmacology and computer science, analyze the data of common medications, and find out the sites that are significantly associated with diseases in the data of common disease medications. In this paper, we use a complex network, R language, rank sum test, displacement test and other data mining methods to retrospectively study some common pediatric cases (such as pediatric cough cases), summarize their medication rules for treating cough in children, and study cough disease. The relationship between the network of the newly diagnosed symptoms and the curative effect provides a reference for the clinical use of traditional Chinese medicine in the treatment of common pediatric diseases, providing ideas for more accurate and effective diagnosis and treatment.
A comparison of calculated and determined apparent ileal digestibility of amino acids in cereal-soyabean diets for young pigs

The digestibility experiment was carried out on twelve cannulated pigs between 14 and 27 kg body weight. The animals were fitted with a PVTC cannula and fed with two starter diets, A and B, differing in metabolizable energy content (13.5 and 14.5 MJ ME/kg, respectively), with no supplemented amino acids (AA), in order to measure digestibility coefficients of protein-bound AA. The diets were formulated to contain 0.6 g ileal digestible lysine/MJ ME and were calculated on the basis of AA analysis of ingredients and their tabular values of apparent ileal AA digestibilities. For both diets, differences between the calculated and determined digestibilities of the limiting essential AA were found. The determined digestibilities tended to be lower than the calculated ones. Of the essen­ tial AA, the differences were greatest for threonine (6.8 and 9.5% of calculated values for diet A and B, respectively) and lysine (4.3 and 8.3% for diet A and B, respectively); the differences for methionine and tryptophan ranged from 4.0 to 6.2%. In conclusion, the present study shows that the digestible A A supply in a diet can be predicted from total AA content determined in the individual ingredients and from average literaturę values recommended for their AA digestibility, however, it is necessary to accept an 8-10% error for calculated values.
A research-informed, school-based professional development workshop programme to promote dialogic teaching with interactive technologies

Abstract The study reported in this article investigated the influence of a research-informed, school-based, professional development workshop programme on the quality of classroom dialogue using the interactive whiteboard (IWB). The programme aimed to develop a dialogic approach to teaching and learning mediated through more interactive uses of the IWB, through a model of active participation of students, collaborative knowledge-building, learning through inquiry and evaluating ideas. Ten professional development workshops based on video-stimulated discussions of practices were co-developed and conducted with an ‘ambassador’ within each of five school clusters. In total, 80 teachers from 15 schools, ranging from infant to secondary schools, participated. Data were collected through surveys, semi-structured interviews with teachers and ambassadors, teachers’ posters created during workshop activities, lesson observations and a portfolio of dialogic classroom practices, mediated by the IWB. Findings strongly support the potential of this ambassador-led workshop model to involve teachers in developing their understandings of classroom dialogue and devising new approaches to support it. The research additionally confirms the potential of the IWB as a tool to support dialogic teaching.