Miracle-dz/UniFAR-FTUs huggingface dataset:
Vibroacoustic treatment and self-care for managing the chronic pain experience: An operational model

Campbell, Elsa A. Vibroacoustic treatment and self-care for managing the chronic pain experience: An operational model Jyväskylä: University of Jyväskylä, 2019, 94 p. (JYU Dissertations ISSN 2489-9003; 95) ISBN 978-951-39-7791-7 (PDF) Chronic pain – pain which lasts longer than three months – is a physiological, psychological, and social phenomenon affecting approximately 20-33% of the world’s population. It contributes to disability, work absenteeism and presenteeism, as well as having economic ramifications. The psychological aspect of chronic pain manifests most commonly in comorbid mood disorders, namely depression and anxiety. They are individually difficult to manage due to their inherently subjective nature; as a combination they are pervasively under-treated. It is understood that chronic pain and mood disorders have a common neurological basis, which supports the use of psychological approaches, such as Cognitive Behavioural Therapy, or mood-targeted pharmacotherapy such as antidepressants, in the management of pain. Vibroacoustic (VA) treatment is both a physiological and psychological approach, beneficial in pain and mood management, however the effects are generally short-term. This dissertation addresses the question of whether practitioner-led VA treatment can be used to manage the psychophysiological symptoms of chronic pain, and whether an adjunct self-care phase is helpful in prolonging the effects. Article I, an interview study, describes the development, current knowledge, and future directions of VA treatment; Article II outlines the standard protocol followed at the multidisciplinary rehabilitation unit at Seinäjoki Central Hospital for multi-symptom patients; Article III explores the role of music listening within VA treatment in a clinical setting; lastly, Articles IV and V investigate the relevance and effects of an adjunct self-care phase to VA treatment sessions offered at the rehabilitation unit. A layered system of outcome measures was also used in these mixed methods studies. Subjective reports were supported by quantitative scales which were further supported by the addition of exploratory physiological outcome measures. The comorbidity of pain and mood disorders was examined in addition to the impact this had on functioning and ability to work, a focal point of the rehabilitation unit featured in the work. Cumulatively, the findings from all five articles, as well as supporting literature, are the foundation upon which the proposed operational model of VA treatment with self-care is based.
Implementierung der S3-Leitlinie Verhinderung von Zwang

Ich arbeite seit 1998 als Kunstund Gestaltungstherapeut (DAGTP) in der Forensischen Klinik des Zentrums für Psychiatrie, Die Weissenau. In Kleingruppen male und steinbildhauere ich mit meinen Patienten. Es ist mir zunehmend wichtiger geworden, zu versuchen, einen „Freiraum zu schaffen“ – damit jeder „sein Ding“ machen kann. Der tiefenpsychologisch reflektierende und inhaltlich aufdeckende Aspekt ist in den Hintergrund getreten. Entscheidend scheint mir ein wirklich offenes Miteinander. Und dazu gehört auch meine persönliche Einlassung – im Gespräch wie auch in den Gestaltungen.
Analysis and research of probabilistic CYK algorithm

Stochastic Chomsky normal form (SCNF) is introduced to parse sentences with probabilistic CYK algorithm . The optimal parsing trees of sentences are gained to eliminate ambiguous meanings. Besides, the search steps in probabilistic CYK algorithm is reduced and the probabilistic CYK algorithm is improved by rearranging grammar rules of SCNF and establishing the index table.Several experiments are given for comparison to validate the approach.
Studying the positive influence of the use of video in teaching & learning environments, focusing on registration of the directions where it improves the PBL effectiveness: A systematic literature review

Previous studies report the involvement of the use of video in the frameworks of problem-based learning (PBL), case-based learning, and project-based learning. This systematic literature review, through two research questions, explores the positive influence of the use of video in those instructional methods, and, while focusing on PBL, identifies and registers the directions where the use of video improves the PBL effectiveness. The findings of this research could prove beneficial to education policy-makers; the frameworks may be more effectively placed to ensure they are used to provide the greatest advantage and benefit. The theoretical model, created and utilized for the needs of this research, resulted as a productive artifact: The positive results of its utilization were reflected mainly in relation with the ordered and grouped 16 identified directions where the use of video improves the effectiveness of PBL, according to the six core characteristics of PBL.
Cluster-based Hybrid Scheduling MAC Protocol for Wireless Sensor Networks

For the application scene with both burst signals and periodic signals,this paper proposes a cluster-based hybrid scheduling MAC protocol for wireless sensor networks——CBPMAC/TFC(A Cluster-based Wireless Sensor Network MAC Protocol for the System with Burst and Periodic Signals/Based on TDMA,FDMA,CSMA). Among different clusters,a FDMA scheduling mechanism is adopted.In clusters,a coordinate Scheduling mechanism based on TDMA and CSMA is adopted.For the requirement of synchronization,a cluster-head-based relative time synchronization mechanism is proposed.The synchronization precision is the clock drifting of a sampling period.In addition,an energy-aware cluster-head alternation strategy and a listening-based disposal strategy for malfunctions are introduced.Analysis and test results show that CBPMAC/TFC is a compromise proposal.Compared with CSMA,CBPMAC/TFC will lose some real-time response for burst signals,but can save energy consumption by 18.7%. Compared with TDMA,CBPMAC/TFC may consume more energy by 23.6%,but can improve real-time response for burst signals.
Growth in Infants Receiving Modified Fat Breast Milk for the Treatment of Chylothorax following Cardiothoracic Surgery

Background: In infants diagnosed with chylothorax, breast milk provision is often discontinued and a medium chain triglyceride (MCT) formula is prescribed. Alternatively, modified fat breast milk (MFBM) can be used as treatment, however its impact on growth is unclear. Objective: To assess growth in cardiac infants receiving nutrient enriched MFBM for chylothorax treatment. Methods: In this open-label trial, infants were randomized in to one of two interventions: Target Fortification, where MFBM protein concentration was measured prior to fortification (n=3); or Higher Initial Concentration, where MFBM was fortified to a higher initial energy and nutrient level (n=2). For this thesis, analysis of the two MFBM interventions were combined. Growth was compared to infants receiving the standard MCT formula treatment (n=7). Results: No differences were found in the change of weight-for-age, length-for-age, head circumference-forage and weight-for-length z-scores between the groups. Conclusion: Further MFBM subject recruitment is required to determine how the different nutrient enrichment methods impact
Cardiovascular and metabolic side effects of second-generation antipsychotics - narrative review

Since their introduction, the use of second generation antipsychotics (SGAs) has extended far beyond schizophrenia. With the increased usage of these agents, particular attention has been paid to their metabolic and cardiac side effects. This narrative review is an attempt to briefly summarize the conclusions from recently published systematic reviews on cardio-metabolic side effects of SGAs. Although no SGA is entirely free of these adverse effects, there are major differences in their prevalence between the specific medications. Numerous studies demonstrated particularly unfavorable side effect profiles of olanzapine and clozapine. The lack of conclusive data is a major limitation for many studies, particularly in the pediatric population. In this article we also discussed the meanings of these findings, suggested cardio-metabolic screening during SGA treatment and side effect management strategies.
Creating a Framework for Application of Transferability Approach

Evolving robot controllers in simulators has been proved to be an effective method of replacing tests on real robots. Flexibility of evolutionary algorithms coupled with cost-effectiveness of running simulations rather than using expensive hardware, made all the mentioned topics an attractive research goal. However, simulating a robot leads to a so-called reality gap, reducing overall viability of the method for creating gaits for quadruped robots. Transferability Approach has been proposed as a method for avoiding solutions leading to reality gap, thus improving performance of the evolved gaits in the reality. This thesis focuses on creating a framework for conducting experiments with Transferability Approach. A fixed 3D model of Aracna is used in a simulator based on Nvidia’s Physx platform as a foundation for creating parameterized controllers. It also features an abstracted model of the real robot, which is used to transfer movements from created gaits to a real robot. On top of that, a surrogate model present in the simulator is able to use data gathered from previous transfer experiments to estimate how well a given gait will perform in the reality. The framework has been implemented and tested on the real robot. The first results look promising with regard to simulating the robot and transferring gaits to the hardware, despite a considerable reality gap. Transferability Approach was applied without any success, though the amount of data used and generated in the experiment is not large enough to be conclusive. Further investigation is required in order to determine viability of the proposed method.
The Relationship Between Plantarflexor Moment Arm, Muscle Activation Patterns And Gait Velocity In The Elderly

Previous research suggests a link between the onset of functional dependence, mortality, and reductions in gait velocity among elderly, associated with effects of aging on the musculoskeletal and nervous systems. Yet underlying processes contributing to these reductions are not well known. The purpose of this study was to investigate ankle structure and lower limb muscle activation to identify differences which could be related to reduced gait velocity seen in aging. No association was found between gait velocity and PFMA (r = -0.13, p = 0.627) but a low positive correlation was found between effective mechanical advantage (EMA) and medial gastrocnemius (MG-LG) bias in stance (r = 0.42, p = 0.108). The present study does not confirm links between moment arm and gait velocity or stance phase muscle bias in elderly observed previously. Elderly subjects might not modify neuromuscular control similar to younger individuals with lower EMA. Indicating the possibility of dedifferentiation and loss of complexity within a younger elderly group that was physically active. Previously suggested relationships between these variables may have task-intensity dependencies relative to the groups studied. To this point, the influence of ankle joint leverage and lower leg neuromuscular activation patterns in elderly gait decline remain unclear.
Cooperative parallel adaptive neighbourhood search for the disjunctively constrained knapsack problem

ABSTRACT This article investigates the use of parallel computing for solving the disjunctively constrained knapsack problem. The proposed parallel computing model can be viewed as a cooperative algorithm based on a multi-neighbourhood search. The cooperation system is composed of a team manager and a crowd of team members. The team members aim at applying their own search strategies to explore the solution space. The team manager collects the solutions from the members and shares the best one with them. The performance of the proposed method is evaluated on a group of benchmark data sets. The results obtained are compared to those reached by the best methods from the literature. The results show that the proposed method is able to provide the best solutions in most cases. In order to highlight the robustness of the proposed parallel computing model, a new set of large-scale instances is introduced. Encouraging results have been obtained.
Oral Health Status of Athletes with Intellectual Disabilities: A Review

BACKGROUND: Oral health reflects the overall health of an individual; it impacts the mental and physical well-being, quality of life, and social relations of an individual. Special Olympics (SO) athletes have been found to have poorer oral health, and high unmet treatment needs globally. Nine articles are included in this systematic review to determine the oral health status of Special Olympics athletes with intellectual disabilities. AIM: To identify the oral health status of athletes with intellectual disabilities who participated in the Special Olympics. METHODS: Electronic bibliographic databases (PubMed, Biology database, Health management database, Science Direct, Health and medical collection (ProQuest), Mendeley, and Health reference centre academic) were used to search for eligible publications using “oral health,” “special needs athletes,” and “intellectual disabilities” terms. All included articles are in English and were published from 2000–2018. The whole process was conducted following PRISMA guidelines. RESULTS: The search strategy yielded 4,090 articles. Only nine articles met the criteria and were included in the final analysis. All included articles reported outcome measurements of gingival signs, missing teeth, untreated decay, filled teeth and sealant. CONCLUSION: The oral health status of athletes with intellectual disabilities can be considered poor compared with athletes without intellectual disabilities, which points to the need for oral health policies for this specific population.
Effect of Melatonin on Incidence Rate of Delirium in Elderly Patients Undergoing Open-Heart Surgery without a Pump: A Clinical Trial

Introduction: Delirium has been considered as the most common cognitive disorder after major surgery. Melatonin therapy is effective in reducing the incidence of delirium after open heart surgery with pain relief mechanism and adjustment of the sleep cycle and the absence of specific side effects. This study was conducted to determine the effectiveness of melatonin on prevention of delirium after coronary artery bypass surgery. Methods: The double blind randomized controlled clinical trial recruited 140 patients, equally decided, who underwent coronary artery bypass surgery in Afshar Hospital, Yazd city, 2016. All participants of the two groups were evaluated for the presence of delirium on the day of surgery and three days after by the Confusion Assessment Method for ICU (CUM-ICU). Respectively, The intervention and control group received 3 mg melatonin and 3 mg placebo orally before and after the operation. Data were analyzed by Chi-square, T-test, paired t-test and Cochran tests. Results: The incidence of delirium in the melatonin and the control group was 35.7% and 5.7% on the day of operation, 68.6% and 31.4% three days after the operation, respectively. The results showed that there was a significant difference in the frequency of cognitive test of CAM-ICU on day of surgery and three days after surgery between the two groups (p <0.001). Conclusion: Despite the efficacy of melatonin therapy in reducing delirium, further studies on the effects of other effective drugs on the treatment of delirium, such as antipsychotics and receptor blockers, should be considered.
How well can electronic health records from primary care identify Alzheimer’s disease cases?

Background Electronic health records (EHR) from primary care are emerging in Alzheimer’s disease (AD) research, but their accuracy is a concern. We aimed to validate AD diagnoses from primary care using additional information provided by general practitioners (GPs), and a register of dementias. Patients and methods This retrospective observational study obtained data from the System for the Development of Research in Primary Care (SIDIAP). Three algorithms combined International Statistical Classification of Diseases (ICD-10) and Anatomical Therapeutic Chemical codes to identify AD cases in SIDIAP. GPs evaluated dementia diagnoses by means of an online survey. We linked data from the Register of Dementias of Girona and from SIDIAP. We estimated the positive predictive value (PPV) and sensitivity and provided results stratified by age, sex and severity. Results Using survey data from the GPs, PPV of AD diagnosis was 89.8% (95% CI: 84.7–94.9). Using the dataset linkage, PPV was 74.8 (95% CI: 73.1–76.4) for algorithm A1 (AD diagnoses), and 72.3 (95% CI: 70.7–73.9) for algorithm A3 (diagnosed or treated patients without previous conditions); sensitivity was 71.4 (95% CI: 69.6–73.0) and 83.3 (95% CI: 81.8–84.6) for algorithms A1 (AD diagnoses) and A3, respectively. Stratified results did not differ by age, but PPV and sensitivity estimates decreased amongst men and severe patients, respectively. Conclusions PPV estimates differed depending on the gold standard. The development of algorithms integrating diagnoses and treatment of dementia improved the AD case ascertainment. PPV and sensitivity estimates were high and indicated that AD codes recorded in a large primary care database were sufficiently accurate for research purposes.
Decellularization of Human Pericardium with Potential Application in Regenerative Medicine

Decellularization of Human Pericardium with Potential Application in Regenerative Medicine Estela de Oliveira Lima,1 Adriana Camargo Ferrasi,1 Andreas Kaasi2 Universidade Estadual Paulista Júlio de Mesquita Filho FMB Depto. Clínica Médica,1 Botucatu, SP – Brazil Santa Casa de Misericórdia de São Paulo Instituto de Pesquisa, Inovação Tecnológica e Educação,2 São Paulo, SP – Brazil Short Editorial related to the article: Characterization of Decellularized Human Pericardium for Tissue Engineering and Regenerative Medicine Applications
Health communication messaging about HPV vaccine in Papua New Guinea

Objective: The type of health education messages that communities and individuals seek to have communicated about the human papillomavirus (HPV) vaccine is important if vaccine programmes are to succeed, especially in settings such as Papua New Guinea (PNG), which have a high burden of cervical cancer, low health literacy and negative experiences of earlier vaccination programmes. This study sought to identify the health education messages that are viewed as most appropriate in such a context. Methodology: A qualitative study using gender-specific focus group discussions (N = 21) and semi-structured interviews (N = 82) was undertaken in three sites in PNG. Sites included both rural and urban locations in Milne Bay, Eastern Highlands and Western Highlands Provinces. Results: Two divergent discourses emerged. One group of participants, largely young people, felt communication messages should stress that HPV is a preventable sexually transmitted infection, which can cause cervical cancer. The other group, mainly members of the older population, believed that messaging should focus on the vaccine as a prevention strategy for cervical cancer. A small minority wanted both aspects of the vaccine discussed. Conclusion: Sensitivity needs to be taken when engaging with communities which have negative experiences of earlier infant immunisation programmes. Ensuring that the health communication needs and priorities of different sections of the populations are taken into account is key to the successful introduction and roll-out of HPV vaccination in this setting.
Empfehlungen zur Malariaprophylaxe

Die Deutsche Gesellschaft für Tropenmedizin und Internationale Gesundheit (DTG) erarbeitet jährlich Empfehlungen zu Reiseimpfungen und zur Malariaprophylaxe. Bis zum vorigen Jahr wurden diese Empfehlungen in den bekannten gelben und grünen Heften veröffentlicht. Um unabhängig von externen Sponsoren zu sein, werden diese Empfehlungen seit 2019 in der FTR publiziert. In diesem Jahr erfolgt die Erarbeitung der Empfehlungen zudem bereits zum zweiten Mal durch den Ständigen Ausschuss Reisemedizin (StAR) der DTG. Dieser setzt sich aus Expertinnen und Experten der großen Tropeninstitute und tropenmedizinischen Abteilungen, des Auswärtigen Amtes, der Bundeswehr, der Gesellschaft für Internationale Zusammenarbeit (GIZ), der Arbeitsmedizin, der Flugmedizin und maritimen Medizin und des niedergelassenen Bereichs zusammen [1]. Im StAR ist damit ein großer Teil der reisemedizinischen Expertise in Deutschland vertreten. Die im Folgenden gewählte männliche Form bezieht sich immer zugleich auf weibliche und männliche Personen. Auf eine Doppelbezeichnung wird zugunsten einer besseren Lesbarkeit verzichtet.
Screening of potential biomarkers in hepatitis C virus-induced hepatocellular carcinoma using bioinformatic analysis

Evidence suggests that hepatitis C virus (HCV) infection is among the main causes of hepatocellular carcinoma (HCC). In addition, HCV-induced HCC (HCV-HCC) exhibits adverse clinical outcomes and limited therapeutic treatments are available for this condition. To investigate key biomarkers in the occurrence and development of HCV-HCC, microarray datasets GSE62232, GSE69715 and GSE107170 were downloaded from the Gene Expression Omnibus database for analysis. The differentially expressed genes between HCV-HCC and normal tissue were identified using the GEO2R online tool. The function enrichment analyses including Gene Ontology and Kyoto Encyclopedia of Genes and Genomes were performed using the Database for Annotation, Visualization and Integrated Discovery online tool. A protein-protein interaction network was constructed using the Search Tool for the Retrieval of Interacting Genes database and visualized using Cytoscape. A total of 368 DEGs were identified, and the top 10 hub genes with a high degree of connectivity were selected for further analysis. Subsequently, overall survival and disease-free survival analysis revealed that there was a significant association between altered expression of HMMR, CCNB1 and KIF20A, and poor clinical outcome. In summary, these results indicate that HMMR, CCNB1 and KIF20A are potential targets for diagnosis and therapy of HCV-HCC.
Mononuclear cells derived from human umbilical cord blood alleviate behavioral deficits and modulate the neuroglial inflammatory response after hypoxic-ischemic brain injury in a neonatal rat model

Trotz der Fortschritte in der Pravention des perinatalen hypoxisch-ischamischen Hirnschadens ist dieser auch in den Industrienationen noch heute eine haufige Ursache fur fruhe und chronische neurologische Defizite. Die Zelltherapie mit humanen Nabelschnurblutzellen gilt als moglicher Therapieansatz. In der aktuellen Arbeit konnte in einem Rattenmodell des perinatalen hypoxisch-ischamischen Hirnschadens eine Langzeitverbesserung motorischer Defizite nach der Transplantation von humanen Nabelschnurblutzellen gezeigt werden. Diese Effekte waren unabhangig vom Transplantationsort (systemisch versus intrathekal). Zudem wurden zeitlich korrespondierende Veranderungen in der Morphologie und Aktivierung glialer Zellen in den lasionierten Gehirnen untersucht und quantifiziert, die den therapeutischen Effekten zugrundeliegen konnen. Hier zeigte sich besonders eine Beschleunigung des Abklingens der postischamischen Entzundungsreaktion und eine schwachere Auspragung der Glianarbe.