Miracle-dz/UniFAR-FTUs huggingface dataset:
Computer-assisted myocardial blush quantification after percutaneous coronary angioplasty for acute myocardial infarction: a substudy from the TAPAS trial.

AIMS Myocardial reperfusion after acute myocardial infarction can be angiographically assessed by the myocardial blush grade (MBG) or TIMI Perfusion Grade. These scores are based on subjective human judgement and lead to a score of four categories. A more operator-independent way of scoring myocardial perfusion may facilitate research in this area. METHODS AND RESULTS We designed the 'Quantitative Blush Evaluator' (QuBE), a computer program which calculates a score for myocardial perfusion. This program will be freely available as open source software. The inter-observer concordance was 97.7%. We calculated values on prospectively collected angiograms in patients with acute ST-elevation myocardial infarction from the TAPAS trial. Quantitative blush evaluator values could be assessed on 790 out of 980 collected angiograms (81%). The QuBE score correlated significantly with MBG as determined by a core lab. The QuBE score predicted complete ST-elevation resolution, low enzyme levels, and 1 year survival (all P < 0.001). Quantitative blush evaluator value was an independent predictor of mortality at 1 year [OR 0.40 (0.17-0.90), P = 0.02]. CONCLUSION The QuBE program provides a practical, freely available computer-assisted assessment of myocardial perfusion. The QuBE score provides a useful surrogate endpoint in trials of therapies aimed at improving myocardial reperfusion.
Hypertension (HTN) and proteinuria (PTN) as biomarkers of efficacy in antiangiogenic therapy for metastatic colorectal cancer (mCRC).

e13580 Background: There are no known predictive markers for the efficacy of vascular endothelial growth factor (VEGF) pathway-targeted therapies. HTN and PTN are known side effects of anti-VEGF therapy. The aim of our study was to assess if HTN and/or PTN with bevacizumab (Bev) or VEGF receptor tyrosine kinase inhibitors (TKI) are associated with clinical outcomes in patients (pts) with mCRC. Methods: We conducted a retrospective analysis of pts with histologically proven mCRC treated with either Bev or TKI in combination with chemotherapy at The Christie Hospital from 2006 to 2009. Results: Of 90 pts evaluated, 50 were eligible. 17 (34%), 4 (8%), and 3 (6%) pts developed Common Toxicity Criteria (CTC) (v 3.0) Grade (Gr) 1, Gr 2 and Gr 3 HTN, respectively. None developed ≥ Gr 4 HTN. Median time to onset of ≥ Gr 2 HTN was 9 (range 2-22) weeks. Response rates (RR) were 42% for pts with Gr 0-1 HTN compared to 86% for pts with ≥ Gr 2 HTN (p=0.043). Median progression free survival (PFS) was 9.4 months for pt.
ON-LAND COMMUNITY-BASED AEROBIC AND STRENGTH TRAINING PROGRAM FOR CHILDREN WITH CEREBRAL PALSY

Research has been conducted on the effects of strength training for children with cerebral palsy but there are large gaps in our understanding of the nature of aerobic limitations and the effects of exercise interventions on function. There is also a paucity of research on the effects of combined interventions involving both strength and aerobic training. For these reasons this study was pursued with the question being what effects, specific to energy expenditure, muscle strength, and perceived satisfaction and perceived performance of a functional motor goal resulted from a community exercise program using both aerobic and anaerobic components for children with cerebral palsy. Six 812 year old children with ambulatory cerebral palsy (able to walk independently >25 meters) participated in four separate tenweek, threetimesperweek exercise and fitness activity programs. All six children demonstrated improvements in energy expenditure and perceived satisfaction while scores were variable for muscle strength. These results offer support for future investigation to explore the potential for aerobic and strength training interventions for children with cerebral palsy.
Military Service and Life Chances in Contemporary China

Abstract: Military service as a turning point that redirects life trajectories has long been recognized in U.S. literature, but it has not been systematically studied in China. Using data from the China Family Panel Studies, this study examines the returns to military service on extensive social outcomes, including tertiary education, marriage, Party membership, income, housing, and occupational status. The study not only compares the outcome differences between male veterans and a matched sample of male nonveterans, but also analyzes variation in military effect across social origin, historical period, life cycle, and service status. The findings show that military service is an important channel for men’s upward mobility in China, but its effect is contingent on when the service occurs, how long the service lasts, and which outcome is under examination.
Lipid-rich plaque and myocardial perfusion after successful stenting in patients with non-ST-segment elevation acute coronary syndrome: an optical coherence tomography study.

AIMS Although some recent guidelines recommend an early invasive strategy for non-ST-segment elevation acute coronary syndrome (NSTEACS), several studies have failed to identify any benefit for very early intervention for NSTEACS. The no-reflow phenomenon may inhibit the expected benefit from very early recanalization for NSTEACS subjects. The aim of this study was to investigate whether optical coherence tomography (OCT) could predict no-reflow in patients with NSTEACS. METHODS AND RESULTS This study comprised 83 consecutive patients with NSTEACS who underwent OCT and successful emergent primary stenting. On the basis of post-stent TIMI flow, patients were divided into two groups: no-reflow group (n = 14) and reflow group (n = 69). Thin-cap fibroatheroma (TCFA) was defined as a plaque presenting lipid content for >90 degrees , and with thinnest part of the fibrous cap measuring <70 microm. Thin-cap fibroatheroma were more frequently observed in the no-reflow group than in the reflow group (50% vs. 16%, P = 0.005). The frequency of the no-reflow phenomenon increases according to the size of the lipid arc in the culprit plaque. Final TIMI blush grade also deteriorated according to the increase in the lipid arc. A multivariable logistic regression model revealed that lipid arc alone was an independent predictor of no-reflow (odds ratio 1.018; CI 1.004-1.033; P = 0.01). CONCLUSION Optical coherence tomography can predict no-reflow after percutaneous coronary intervention (PCI) in NSTEACS. The lipid contents of a culprit plaque may play a key role in damage to the microcirculation after PCI for NSTEACS. From our results, it is found that OCT is useful tool for stratifying risk for PCI for NSTEACS.
Engagement in community-based day centres for people with psychiatric disabilities

This thesis provides knowledge of occupational engagement in day centres for people with psychiatric disabilities and contributes to measurement development in the area of occupational engagement. The first study focused on the characteristics of the occupations carried out at the day centre by exploring occupational engagement using time-use diaries with a person-environment-occupation perspective. The occupations performed were categorized as social occupations, maintenance occupations, creative occupations, manufacturing occupations, service occupations and information-focused occupations. The study also showed that being at the day centre meant participating in occupations with varying levels of demands on the individual. The second study highlighted that attendance in day centres brought a feeling of being socially included through participation in occupations. Attendance in day centres created structure and routines, and the perceptions of contributing and being entrusted with responsibilities were considered motivational. The attendees were challenged to learn new things, to be more active and to master new goals in their daily life, and were in a process of seizing control over their everyday lives. The third study was a psychometric study of the Profile of Occupational Engagement in people with Severe mental illness - Productive occupations (POES-P). The findings indicated good internal consistency, and a logical pattern of relationships between the POES-P and other instruments was found. POES-P was considered to be mainly a construct in its own right. The distribution of responses indicated a ceiling effect, which calls for further development of the instrument. Study IV revealed a stepwise indication of which factors are most likely to be important for occupational engagement. The participants’ psychopathology, especially general symptoms, and time spent at the day centre were important factors for reaching occupational engagement above a medium level, and self-mastery was the only variable associated with belonging to the group with the highest level (> the 75th percentile) of occupational engagement.
Evaluation of a Public Library Workshop

Abstract Individuals aged 55 and older represent the fastest-growing Internet user group. They are also at higher risk for cancer. Consumer health librarians can teach seniors effective Internet search strategies to access accurate and reliable cancer information. Four Internet workshops were conducted at the Kitchener Public Library with 44 community-dwelling older adults aged 50 to 75. Participants learned how to search the Internet for cancer information using search engines, medical directories, and subject starters. Results of post-workshop questionnaires showed that over 80% of seniors felt comfortable searching independently for Web-based cancer information after the workshop. Searching difficulty decreased from 5.2 pre-workshop to 4.3 post-workshop (1 = very easy; 10 = very difficult). Self-rated understanding (1 = poor understanding; 5 = excellent understanding) of the Internet was also higher post-workshop (3.9/5) compared to pre-workshop (2.4/5). Seventy percent of participants indicated that they would definitely turn to the Internet for cancer information in the future. The library workshops were effective in teaching Internet search skills to older adults. Librarians and health information providers should guide seniors' use of the Internet so they are able to access high quality cancer Web sites.
Integrated primary care: The future of medical and mental health collaboration.

Integrated primary care, now instituted in many areas of the country, is both the service that integrates medical and mental health primary care and the practice of defining the problem brought by a patient without using "medical" or "mental" as inevitable distinctions. This volume makes the case for this approach, shows how to implement it, and describes some successful programs. It will be attractive to medical managers, plan administrators, physicians, and mental health providers.
The quest for diagnosis - a narrative analysis of patient journeys

This paper presents an analysis of narratives written by patients for a series in the British Medical Journal titled ‘A Patient’s Journey’. Narratives written by patients with rare diseases were selected and analysed as quest narratives. Two notable features of the narrative were the lack of helpers on the journey and the shock of diagnosis. Also notable was the lack of mention, in these accounts of journeys, of places visited.
Tilt testing and neurally mediated syncope: too many protocols for one condition or specific protocols for different situations?

Syncope, defined as a transient loss of consciousness due to transient global cerebral hypoperfusion, characterized by rapid onset, short duration, and spontaneous complete recovery, is a frequent symptom and can be attributed to different causes.1 The most common aetiology of syncope is a neurally mediated reflex that consists of a transient failure of the cardiovascular mechanisms that normally control haemodynamic stability. This reflex is usually triggered by different stimuli (afferent pathways), leading to sudden withdrawal of sympathetic activity and to an increase in parasympathetic nerve tone (efferent pathways), causing vasodilatation, with consequent hypotension, and bradycardia. The clinical presentation of neurally mediated syncope is not usually uniform; however, it may manifest with different patterns. In some patients, it is initiated by clear adrenergic stimuli such as fear, pain, emotional distress, or medical instrumentation, whereas in others it develops after prolonged orthostatism, hypovolaemia, or carotid sinus stimuli. There are also many patients in whom reflex syncope develops without any apparent recognizable trigger. On the other hand, some patients complain of typical vegetative prodrome, whereas others develop sudden syncope without any warning symptom. In addition, although both mechanisms, hypotension and bradycardia, are, by definition, always present, the predominance of one or the other leads to the characteristic patterns of vasodepressor, mixed, or cardioinhibitory reflex syncope.2 Although all these situations share a common underlying mechanism, i.e. hypotension and bradycardia triggered by some afferent stimuli, these differences have a great impact on the diagnostic process and in therapeutic decisions. Whereas a syncopal episode in a young patient, with clear triggers and prodrome, is easy to diagnose and manage, sudden episodes, without recognizable triggers, particularly … *Corresponding author. Tel: +34 932746166, Fax: +34 932746002, Email: 11193amm{at}comb.es; amoya{at}comb.es
The Relationship of Technology Use to Perception of Instructional Quality

iv Acknowledgments. vi List of Tables . xiii List of Figures . xv Chapter 1: Introduction . 1 Background of the Study . 1 Teacher Preparation . 2 Statement of the Problem. 2 The Seven Principles for Good Practice in Undergraduate Education . 3 Purpose of the Study . 5 Research Question . 5 Significance of the Study . 6 Scope of the Study . 7 Definition of Terms. 8 Limitations and Delimitations of the Study . 10 Summary . 11 Organization of the study. 12 Chapter 2: Review of Relevant Literature . 13 Introduction. 13 Teacher Preparation Programs and Technology Integration . 13 The Seven Principles for Good Practice in Undergraduate Education . 17 ix Good Practice Encourages Student –Faculty Contact . 19 Good Practice Encourages Cooperation Among Students. 24 Good Practice Encourages Active Learning . 27 Good Practice gives prompt feedback. 32 Good Practice Emphasizes Time on Task . 35 Good Practice Communicates High Expectations . 38 Good Practice Respects Diverse Talents and Ways of Learning. 42 Technologies Used to Support Teaching . 46 Programs used to support teaching in Higher Education. 51 The International Society for Technology in Education (ISTE). 52 National Educational Technology Standards (NETS) . 53 The National Council for Accreditation of Teacher Education (NCATE) . 59 Summary . 66 Chapter 3: Research Methodology. 76 Introduction. 76 The Research Question . 76 Research Design. 77 Operational Definitions of the Variables . 79 Independent Variables . 79 Dependent Variable . 79 The Setting . 79 Population of the Study. 82
Effect of Two Exercise Programs on Balance Scores in Elderly Ambulatory People

The purpose of this study was to determine the effect of two exercise programs on balance in elderly, ambulatory people. Thirteen residents of a long term care facility were randomly assigned to a control (N = 7) or experimental group (N = 6). Both groups received supervised exercise twice each week for eight weeks. The control group performed “traditional” exercises while the experimental group performed the same traditional exercises plus exercises on a Swiss gymnastics ball. Each subject's balance was tested before and after the exercise program using the Tinetti Assessment Tool. Both groups demonstrated non-significant increases in balance scores following completion of the exercise program. Individuals with initial balance scores less than 19 did not improve regardless of the exercise program. Subjects with initial scores greater than 21 displayed improvements in their final scores. These findings suggest the initial balance score, not the type of exercise program, may be a critical factor for improving balance in the elderly.
Development and Evaluation of a Chronic Care Competency Scale for Primary Care Team in Thailand

A bstract The Thai health care system currently has no tool available to measure chronic care competency in primary care settings. This research aimed to develop a conceptual structure and evaluate a Chronic Care Competency Scale (CCCS) for primary care teams in Thailand. The CCCS was developed using a concept analysis from literature reviews. In-depth interviews of Thai primary care team members were used to form the specified domains, which were used to generate an item pool consisting of 50 items whose content validity was tested by 9 experts (CVI = 0.95). The retained 40-item CCCS was further evaluated by 35 primary care team members and yielded high internal consistency (α= 0.98). The field test was conducted in 434 primary care team members, resulting in a high reliability of the 40-item CCCS (α = 0.97). The exploratory factor analysis (EFA) was used to test its construct validity; the final version of the 40-item CCCS revealed three domains: 1) basic medical care, 2) health risk management and symptom control, and 3) community resources management. The construct validity evaluation using hypothesis testing reported a positive correlation between years of education and the total CCC scores (r = 0.58, p< 0.01). Moreover, the stability evaluation, using the test-retest method, demonstrated a correlation between time 1 and time 2 testing (r = 0.90, p< 0.01). Therefore, the CCCS can be used to measure the chronic care competency for Thai primary care teams such as nurses since it demonstrated adequate validity and reliability.
Expanding the understanding of how parenting influences the dietary intake and weight status of children: A cross‐sectional study

Aim: The present study explored whether existing tools measuring parenting could be combined to assess an expanded parenting definition, specifically to include co-participation in food-related activities and teaching children about nutrition. The relationships between parenting, child dietary intake and weight outcomes were explored. Methods: The sample included 93 children aged 4–13 years and their parent/caregiver. Child outcomes were dietary intake and body mass index z-score. Parent measures included demographics, nutrition knowledge and parenting practices. Exploratory factor analysis was used to identify underlying dimensions of parenting. Hierarchical linear regression was used to investigate the independent effects of parenting on child outcomes (body mass index z-score, fruit and vegetable, fibre, saturated and total fat) after adjustment for covariates. Results: Five factors were extracted, accounting for 44% of the total variance (α= 0.77–0.87). The regression model for kilojoules explained 31% of the variance (P= 0.001), with a significant independent contribution from construct ‘guide and reward’ (β=−0.249, P= 0.027). For child body mass index z-score, the model explained 25% of variance, and parenting constructs ‘guide and reward’ (β= 0.274, P= 0.015) and ‘concern about intake’ (β=−0.273, P= 0.008) made significant contributions. Conclusions: The present study adds to our understanding of parenting influences on children's dietary intake and weight status. Results support the inclusion of parenting strategies in obesity prevention interventions. Future research should explore the range of ways parenting influences children's diet and risk of obesity, preferably longitudinally.
Low-dose vs standard-dose unfractionated heparin for percutaneous coronary intervention in acute coronary syndromes treated with fondaparinux: the FUTURA/OASIS-8 randomized trial.

CONTEXT The optimal unfractionated heparin regimen for percutaneous coronary intervention (PCI) in patients with non-ST-segment elevation acute coronary syndromes treated with fondaparinux is uncertain. OBJECTIVE To compare the safety of 2 unfractionated heparin regimens during PCI in high-risk patients with non-ST-segment elevation acute coronary syndromes initially treated with fondaparinux. DESIGN, SETTING, AND PARTICIPANTS Double-blind randomized parallel-group trial in 179 hospitals in 18 countries involving 2026 patients undergoing PCI within 72 hours, nested within a cohort of 3235 high-risk patients with non-ST-segment elevation acute coronary syndromes initially treated with fondaparinux enrolled from February 2009 to March 2010. INTERVENTIONS Patients received intravenously either low-dose unfractionated heparin, 50 U/kg, regardless of use of glycoprotein IIb/IIIa (GpIIb-IIIa) inhibitors or standard-dose unfractionated heparin, 85 U/kg (60 U/kg with GpIIb-IIIa inhibitors), adjusted by blinded activated clotting time (ACT). MAIN OUTCOME MEASURES Composite of major bleeding, minor bleeding, or major vascular access-site complications up to 48 hours after PCI. Key secondary outcomes include composite of major bleeding at 48 hours with death, myocardial infarction, or target vessel revascularization within day 30. RESULTS The primary outcome occurred in 4.7% of those in the low-dose group vs 5.8% in the standard-dose group (odds ratio [OR], 0.80; 95% confidence interval [CI], 0.54-1.19; P = .27). The rates of major bleeding were not different but the rates of minor bleeding were lower with 0.7% in the low-dose group vs 1.7% in the standard-dose group (OR, 0.40; 95% CI, 0.16-0.97; P = .04). For the key secondary outcome, the rates for low-dose group were 5.8% vs 3.9% in the standard-dose group (OR, 1.51; 95% CI, 1.00-2.28; P = .05) and for death, myocardial infarction, or target vessel revascularization it was 4.5% for the low-dose group vs 2.9% for the standard-dose group (OR, 1.58; 95% CI, 0.98-2.53; P = .06). Catheter thrombus rates were very low (0.5% in the low-dose group and 0.1% in the standard-dose group, P = .15). CONCLUSION Low-dose compared with standard-dose unfractionated heparin did not reduce major peri-PCI bleeding and vascular access-site complications. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00790907.
Diagnostic accuracy of 320-row multidetector computed tomography coronary angiography in the non-invasive evaluation of significant coronary artery disease.

AIMS Multidetector computed tomography coronary angiography (CTA) has emerged as a feasible imaging modality for non-invasive assessment of coronary artery disease (CAD). Recently, 320-row CTA systems were introduced, with 16 cm anatomical coverage, allowing image acquisition of the entire heart within a single heart beat. The aim of the present study was to assess the diagnostic accuracy of 320-row CTA in patients with known or suspected CAD. METHODS AND RESULTS A total of 64 patients (34 male, mean age 61 +/- 16 years) underwent CTA and invasive coronary angiography. All CTA scans were evaluated for the presence of obstructive coronary stenosis by a blinded expert, and results were compared with quantitative coronary angiography. Four patients were excluded from initial analysis due to non-diagnostic image quality. Sensitivity, specificity, and positive and negative predictive values to detect > or =50% luminal narrowing on a patient basis were 100, 88, 92, and 100%, respectively. Moreover, sensitivity, specificity, and positive and negative predictive values to detect > or =70% luminal narrowing on a patient basis were 94, 95, 88, and 98%, respectively. With inclusion of non-diagnostic imaging studies, sensitivity, specificity, and positive and negative predictive values to detect > or =50% luminal narrowing on a patient basis were 100, 81, 88, and 100%, respectively. CONCLUSION The current study shows that 320-row CTA allows accurate non-invasive assessment of significant CAD.