Miracle-dz/UniFAR-FTUs huggingface dataset:
Types of Caregiving Experience and Their Association With Caregiver Depressive Symptoms and Quality of Life

Objective This study examines distinct types of caregiving experience, each formed by varied combinations of caregiving burden and benefits, and their association with caregiver depressive symptoms and quality of life. Methods: We apply latent profile analysis and multivariable regression to data on 278 caregivers participating in the Caregiving Transitions among Family Caregivers of Elderly Singaporeans (TraCE) study in 2019–2020. Results: We identify four caregiving experience types: (1) balanced (low burden and moderate benefits, 40% of caregivers), (2) satisfied (low burden and high benefits, 33%), (3) intensive (high burden and high benefits, 17%), and (4) dissatisfied (moderate burden and low benefits, 10%). Caregivers with dissatisfied and intensive caregiving experience tend to report higher depressive symptoms and lower quality of life compared to those with satisfied caregiving experience. Discussion: A person-centered approach helps capture the heterogeneity in caregiving experience. Policymakers should develop tailored interventions by caregiving experience types for promoting caregiver well-being.
Prolonged postoperative ileus following right‐ versus left‐sided colectomy: A systematic review and meta‐analysis

Prolonged postoperative ileus (PPOI) is a common complication following colonic surgery, and is associated with longer hospital stay, greater risk of complications and substantial cost for patients and hospitals. Some reports have recently suggested that gastrointestinal (GI) recovery varies based on the side of resection (i.e., right‐sided vs. left‐sided colectomy). This systematic review and meta‐analysis aimed to compare GI recovery by resection side.
Maturation of Stem Cell-Derived Cardiomyocytes: Foe in Translation Medicine

With the in-depth study of heart development, many human cardiomyocytes (CMs) have been generated in a laboratory environment. CMs derived from pluripotent stem cells (PSCs) have been widely used for a series of applications such as laboratory studies, drug toxicology screening, cardiac disease models, and as an unlimited resource for cell-based cardiac regeneration therapy. However, the low maturity of the induced CMs significantly impedes their applicability. Scientists have been committed to improving the maturation of CMs to achieve the purpose of heart regeneration in the past decades. In this review, we take CMs maturation as the main object of discussion, describe the characteristics of CMs maturation, summarize the key regulatory mechanism of regulating maturation and address the approaches to promote CMs maturation. The maturation of CM is gradually improving due to the incorporation of advanced technologies and is expected to continue.
Titanium elastic nailing can be used in 6 to 10 years old pediatric with Delbet IV femoral neck fractures

Abstract The purpose of this study was to analyze the outcomes of titanium elastic nail (TEN) for the children in 6 to 10 years old who sustained a Delbet IV femoral neck fracture. A total of 56 children aged 6 to 10 years old with Delbet IV femoral neck fracture treated with TEN or cannulated screw (SC) were identified at our hospital from January 2009 to December 2019. Of which 24 were treated with TEN, and 32 with SC. All of them were followed up for 1 year after operation, and the differences in operation time, intraoperative blood loss, hospitalization time, hip joint function, and complication between the 2 groups were compared. Harris and Ratliff hip score were used to evaluate the hip function. All 56 fractures united properly. No major complications were noted in both groups. The intraoperative blood loss and operation time in TEN group and SC group were (11.42 ± 3.41) mL, (19.66 ± 4.05) mL (P = .000) and (33.58 ± 7.89) min, (40.22 ± 7.48) min (P = .002), respectively. There was no significant statistical difference between hip regarding range of motion and femoral neck-shaft angle in both groups, as well as Harris and Ratliff hip score between the 2 groups. TEN represent safe and effective methods in the treatment of Delbet IV femoral neck fracture in 6 to 10 years old children. TEN internal fixation is a minimal invasive and simpler technique and suitable for young children of Delbet IV femoral neck fracture.
Conformational dynamics and energetics of viral RNA recognition by lab-evolved proteins

The conserved and structured elements in viral RNA genomes interact with proteins to regulate various events in the viral life cycle and have become key targets for developing novel therapeutic approaches. We probe physical interactions between lab-evolved proteins and a viral RNA element from the HIV-1 genome. Specifically, we study the role of an arginine-rich loop in recognition of designed proteins by the viral RNA element. We report free energy calculations to quantitatively estimate the protein/RNA binding energetics, focusing on the mutations of arginine residues involved in recognition of the major groove of RNA by proteins.
Comparison of methods to develop fingerprints on papers impregnated with AB‐PINACA and AB‐FUBINACA

Although there have been significant advances in fingerprinting techniques, studies on how these techniques affect other criminal evidence are limited. Synthetic cannabinoids (SC), which are illegal substances frequently encountered in crime scenes and are widely used worldwide, are available in various forms in the market (pill, powder, liquid, and herbal product). These synthetic cannabinoid substances have recently been introduced to places such as prisons and rehabilitation centers, primarily via an infused piece of paper. The first seizure of the paper‐impregnated form of AB‐PINACA and AB‐FUBINACA in Turkey was observed in 2014. This study investigates the effects of fingerprint development methods on the concentrations of these SCs impregnated on paper. Therefore, eccrine and sebaceous fingerprints of volunteers were imprinted on the papers before and after they were impregnated with AB‐PINACA and AB‐FUBINACA. Six different fingerprint development methods were applied. Fingerprint development methods were later checked in 384 fingerprints. AB‐PINACA and AB‐FUBINACA infused on papers were extracted by the liquid−extraction method, and concentrations were analyzed via LC‐MS/MS. After applying Thermanin, 1,2‐indandione, iodine vapor, DFO, and 5‐MTN fingerprint development methods, the concentration levels of AB‐FUBINACA were 26.25, 19.60, 21.43, 17.76, and 17.77 ng/cm2, while the concentration levels of AB‐PINACA were 1.1, 0.98, 1.31, 1.28, and 1.22 ng/cm2, respectively. Finally, although the best fingerprint visualization was obtained on papers that were applied the Ninhydrin method, the method failed to detect SCs on papers.
Myocardial uptake of 68Ga-DOTATATE: correlation with cardiac disease and risk factors

Background Myocardial uptake on 68Ga-DOTATATE PET/CT is often observed and its clinical relevance is poorly understood. Purpose To detect any correlation between myocardial uptake of 68Ga-DOTATATE and presence of cardiac disease or risk factors. Material and Methods In this institutional review board-approved retrospective study, we reviewed 68Ga-DOTATATE PET/CT scans in our institution between 1 May 2018 and 30 September 2018. A semi-quantitative score (MUS) for myocardial uptake of 68Ga-DOTATATE was developed by measuring mean standardized uptake value (SUV) in five myocardial regions, corrected by blood pool activity, and MUS was validated between two readers. We investigated the relationship between MUS and presence of cardiac disease or risk factors, including Framingham score and coronary calcification. Results A total of 145 scans were included (79 women; mean age = 56.9 ± 13.7 years). Inter-reader agreement was excellent with intraclass correlation coefficient (r) = 0.964 (95% confidence interval [CI] = 0.903–0.987; P < 0.001). There was a weak but significant positive correlation between MUS and presence of coronary calcifications (Spearman rho = 0.20; P = 0.016). MUS was higher in patients with heart disease or risk factors (n = 83, mean MUS 2.03, 95% CI = 1.85–2.21) compared to those without (n = 23, mean MUS 1.40, 95% CI = 1.17–1.62; P < 0.001), although the cardiac disease group was older with a higher percentage of men (62.0 years, 57.8% men compared to 47.6 years, 13.0% men; P value <0.0001 for both comparisons). Conclusion For patients undergoing 68Ga-DOTATATE PET/CT scan, an elevated MUS might indicate an underlying heart disease.
Impact of Social Vulnerability on Access to Educational Programming Designed to Enhance Living Donation

Introduction Transplant candidate participation in the Living Donor Navigator Program is associated with an increased likelihood of achieving living donor kidney transplantation; yet not every transplant candidate participates in navigator programming. Research Question We sought to assess interest and ability to participate in the Living Donor Navigator Program by the degree of social vulnerability. Design Eighty-two adult kidney-only candidates initiating evaluation at our center provided Likert-scaled responses to survey questions on interest and ability to participate in the Living Donor Navigator Program. Surveys were linked at the participant-level to the Centers for Disease Control and Prevention Social Vulnerability Index and county health rankings and overall social vulnerability and subthemes, individual barriers, telehealth capabilities/ knowledge, interest, and ability to participate were assessed utilizing nonparametric Wilcoxon ranks sums tests, chi-square, and Fisher's exact tests. Results Participants indicating distance as a barrier to participation in navigator programming lived approximately 82 miles farther from our center. Disinterested participants lived in areas with the highest social vulnerability, higher physical inactivity rates, lower college education rates, and higher uninsurance (lack of insurance) and unemployment rates. Similarly, participants without a computer, who never heard of telehealth, and who were not encouraged to participate in telehealth resided in areas of highest social vulnerability. Conclusion These data suggest geography combined with being from under-resourced areas with high social vulnerability was negatively associated with health care engagement. Geography and poverty may be surrogates for lower health literacy and fewer health care interactions.
Intracranial hemorrhage in newly diagnosed non‐promyelocytic acute myeloid leukemia patients admitted for intensive induction chemotherapy

Intracranial hemorrhage (ICH) in acute myeloid leukemia (AML) patients is a major concern due to the increased risk of mortality. Few studies have examined ICH specifically in newly diagnosed AML patients receiving intensive induction chemotherapy (IC) and prophylactic platelet transfusions during thrombocytopenia <10/nL. This retrospective cohort study included 423 newly diagnosed AML patients without acute promyelocytic leukemia who underwent IC between 2007 and 2019. We assessed risk factors, clinical features, and outcomes of ICH.
A potential source of atmospheric sulfate from O2−-induced SO2 oxidation by ozone

Abstract. It was formerly demonstrated that O2SOO− forms at collisions rate in the gas phase as a result of SO2 reaction with O2-. Here, we present a theoretical investigation of the chemical fate of O2SOO− by reaction with O3 in the gas phase, based on ab initio calculations. Two main mechanisms were found for the title reaction, with fundamentally different products: (i) formation of a van der Waals complex followed by electron transfer and further decomposition to O2 + SO2 + O3- and (ii) formation of a molecular complex from O2 switching by O3, followed by SO2 oxidation to SO3- within the complex. Both reactions are exergonic, but separated by relatively low energy barriers. The products in the former mechanism would likely initiate other SO2 oxidations as shown in previous studies, whereas the latter mechanism closes a path wherein SO2 is oxidized to SO3-. The latter reaction is atmospherically relevant since it forms the SO3- ion, hereby closing the SO2 oxidation path initiated by O2-. The main atmospheric fate of SO3- is nothing but sulfate formation. Exploration of the reactions kinetics indicates that the path of reaction (ii) is highly facilitated by humidity. For this path, we found an overall rate constant of 4.0×10-11 cm3 molecule−1 s−1 at 298 K and 50 % relative humidity. The title reaction provides a new mechanism for sulfate formation from ion-induced SO2 oxidation in the gas phase and highlights the importance of including such a mechanism in modeling sulfate-based aerosol formation rates.
Online learning developments in undergraduate medical education in response to the COVID-19 pandemic: A BEME systematic review: BEME Guide No. 69

Abstract Background The COVID-19 pandemic spurred an abrupt transition away from in-person educational activities. This systematic review investigated the pivot to online learning for nonclinical undergraduate medical education (UGME) activities and explored descriptions of educational offerings deployed, their impact, and lessons learned. Methods The authors systematically searched four online databases and conducted a manual electronic search of MedEdPublish up to December 21, 2020. Two authors independently screened titles, abstracts and full texts, performed data extraction and assessed risk of bias. A third author resolved discrepancies. Findings were reported in accordance with the STORIES (STructured apprOach to the Reporting in healthcare education of Evidence Synthesis) statement and BEME guidance. Results Fifty-six articles were included. The majority (n = 41) described the rapid transition of existing offerings to online formats, whereas fewer (n = 15) described novel activities. The majority (n = 27) included a combination of synchronous and asynchronous components. Didactics (n = 40) and small groups (n = 26) were the most common instructional methods. Teachers largely integrated technology to replace and amplify rather than transform learning, though learner engagement was often interactive. Thematic analysis revealed unique challenges of online learning, as well as exemplary practices. The quality of study designs and reporting was modest, with underpinning theory at highest risk of bias. Virtually all studies (n = 54) assessed reaction/satisfaction, fewer than half (n = 23) assessed changes in attitudes, knowledge or skills, and none assessed behavioral, organizational or patient outcomes. Conclusions UGME educators successfully transitioned face-to-face instructional methods online and implemented novel solutions during the COVID-19 pandemic. Although technology’s potential to transform teaching is not yet fully realized, the use of synchronous and asynchronous formats encouraged virtual engagement, while offering flexible, self-directed learning. As we transition from emergency remote learning to a post-pandemic world, educators must underpin new developments with theory, report additional outcomes and provide details that support replication.
Supraspinal sensorimotor and pain-related reorganization after a hemicontusion rat cervical spinal cord injury.

Since the presence of pain impedes motor recovery in individuals with spinal cord injury (SCI), it is necessary to understand their supraspinal substrates in translational animal models. Using functional magnetic resonance imaging (fMRI) in a rat model of hemicontusion cervical SCI, supraspinal changes were mapped and correlated with sensorimotor behavioral outcomes. Female adult rats underwent sham or SCI using a 2.5 mm impactor and 150 kDyne force. SCI permanently impaired motor activity in only the ipsilesional forelimb along with thermal hyperalgesia at 5 and 6 wks. Spinal MRI at 8 wks after SCI showed ipsilateral T1 and T2 lesions with no discernable lesions across shams. fMRI mapping during electrical forepaw stimulation indicated SCI-induced sensorimotor reorganization with an expansion of the contralesional forelimb representation. Resting state fMRI based functional connectivity density (FCD), a marker of regional neuronal hubs increased or decreased across brain regions involved in nociception. FCD increases after SCI were in the primary and secondary somatosensory cortices (S1 and S2), anterior cingulate cortex (ACC), insula and the prefrontal cortex (PFC) and decreases were across the hippocampus, thalamus, hypothalamus and amygdala in SCI. Resting state functional connectivity (RSFC) assessments from the FCD altered regions of interest indicated cortico-cortical RSFC increases and cortico-insular, cortico-thalamic and cortico-hypothalamic RSFC decreases after SCI. Hippocampus, amygdala and thalamus showed decreased RSFC with most cortical regions and between themselves except the hippocampus-amygdala network, which showed increased RSFC after SCI. While select nociceptive region's intrinsic activity associated strongly with evoked pain behaviors after SCI (eg., PFC, ACC, hippocampus, thalamus, hypothalamus, M1 and S1BF) other nociceptive regions had weaker associations (eg., amygdala, insula, auditory cortex, S1FL, S1HL, S2 and M2), but differed significantly in their intrinsic activities between sham and SCI. The weaker associated nociceptive regions may possibly encode both the evoked and affective components of pain.
Fraction Lipophilicity Index (FLI)

Fraction lipophilicity index (FLI) was developed as a metric for assessing oral drug likeness of ionizable chemical entities, as a weighted combination of log P and log D according to equation: FLI = 2xlog P–log D. The dataset included basic and acidic oral drugs introduced worldwide from 1994-2013. Using MedChemDesigner for logP and logD calculations, a drug-like FLI range of 1-8 is defined, whereas ClogP leads to a broader FLI(C) range of 1-10. A comparison of FLI with Rule of 5 showed that oral drugs with a two fold violation were well accommodated within the specified FLI ranges. Calculations of FLI and FLI(C) for 41 drugs with poor/moderately absorption showed that 40% of them have values outside the suggested drug-like ranges, while a distinct gap in the FLI and FLI(C) space permits the recommendation of ‘safer' ranges: for bases between 5-8 and 5-10 for FLI and FLI(C), respectively, and for acids between 4-7. Application of FLI to a test set of investigational compounds placed all of them within the drug-like FLI/ FLI(C) range, while discriminating two out of three low permeable molecules.
Effect of presurgical aerobic exercise on cardiometabolic health 30 days after bariatric surgery

We evaluated the effect of preoperative standard medical care (SC) vs. unsupervised aerobic exercise combined with SC (EX + SC) on cardiometabolic health and quality of life (QoL) 30 days after bariatric surgery. Bariatric patients (n = 14, age: 42.3 ± 2.5 years, body mass index: 45.1 ± 2.5 kg/m2) were match‐paired to presurgical SC (n = 7) or EX + SC (n = 7; walking 30 min/day, 5 day/week, 65–85% HRpeak) for 30 days. Body composition, peak cardiorespiratory fitness (VO2peak), QoL, inflammation (adiponectin, leptin, cytokeratin‐18), and a 120 min mixed meal tolerance test was performed to assess aortic waveforms (augmentation index, AIx@75), insulin sensitivity, and glucose total area under the curve (tAUC) at the time of surgery (post‐intervention) and 30 days post‐surgery. EX + SC had significantly higher high molecular weight (HMW) adiponectin (p = 0.01) and ratio of HMW to total adiponectin (p = 0.04) than SC at 30 days post‐surgery, although they significantly (p = 0.006; ES = 1.86) decreased total time spent in moderate to vigorous physical activity (MVPA). SC had a significantly greater increase in VO2peak (p = 0.02; ES = 1.54) and decrease in 120 min AIx@75 (p = 0.02; ES = 1.78) than EX + SC during the post‐surgical period. The increase in MVPA was associated with a reduction in cytokeratin‐18 (r = −0.67, p = 0.02). Increased VO2peak was associated with increased activity/mobility QoL domain (r = 0.52, p = 0.05) and decreased 120 min AIx@75 (r = −0.61, p = 0.03) from surgery to post‐surgery. Preoperative EX + SC did not maintain more favorable cardiometabolic health 30 days post‐operation in this pilot study. However, changes in MVPA appear important for QoL and should be considered in future work.
What are the functional consequences after TBI? The SHEFBIT cohort experience

ABSTRACT Objectives To investigate functional outcome after TBI and identify variables that predict outcome in a multiordinal regression model. Background The results of global outcome studies after Traumatic Brain Injury(TBI) differ widely due to differences in outcome measure, attrition to follow-up and selection bias. Outcome information would inform patients/families, guide service development and target high-risk individuals Subjects/Setting prospective cohort of 1322 admissions with TBI, assessed by face to face interviews at 1 yr. Measures Extended Glasgow Outcome Scale (GOSE) by structured questionnaire. Results At 1 year, outcome was determined in 1207(91.3%). Mean age was 46.9(SD17.3); Almost half(49.2%) had mild injury. At one year, 42.9% achieved Good Recovery but GOSE declined in 11.4% of the cohort compared to 10 weeks including 60(4.9%) deaths. In an ordinal logistic regression, increasing TBI severity, etiology (assault), more prominent CT abnormality, past psychiatric history and alcohol intoxication were independent predictors of worse GOSE. A pseudo-R2 of 0.38 suggested that many unmeasured factors also contribute to TBI outcome. Future work needs to identify other variables that may influence outcome. Conclusions In a large TBI cohort, there is still considerable functional disability at 1 year. It may be possible to target high-risk groups for rehabilitation
Keyword spotting for audiovisual archival search in Uralic languages

In this study we investigate the potential of using Automatic Speech Recognition (ASR) for keyword spotting for four Uralic languages: Finnish, Hungarian, Estonian and Komi. These languages also represent different levels on the high and low resource continuum. Although the accuracy of the ASR systems show there is a long way to go, we show that they still have potential to be useful for downstream tasks such as key-word spotting. By using a simple text search after running ASR, we are already able to achieve an F 1 score of between 0.15 and 0.33, a precision of nearly 0.90 for Estonian and Hungarian, and a precision of 0.76 for Komi.
Low-Resource ASR with an Augmented Language Model

It is widely known that a good language model (LM) can dramatically improve the quality of automatic speech recognition (ASR). However, when dealing with a low-resource language, it is often the case that not only aligned audio data is scarce, but there are also not enough texts to train a good LM. This is the case of Beserman, an unwritten dialect of Udmurt (Uralic > Per-mic). With about 10 hours of aligned audio and about 164K words of texts available for training, the word error rate of a Deep-speech model with the best set of parameters equals 56.4%. However, there are other linguistic resources available for Beserman, namely a bilingual Beserman-Russian dictionary and a rule-based morphological analyzer. The goal of this paper is to explore whether and how these additional resources can be exploited to improve the ASR quality. Specifically, I attempt to use them in order to expand the existing LM by generating a large number of fake sentences that in some way look like genuine Beser-man text. It turns out that a sophisticated enough augmented LM generator can indeed improve the ASR quality. Neverthe-less, the improvement is far from dramatic, with about 5% decrease in word error rate (WER) and 2% decrease in character error rate (CER). Abstract