Miracle-dz/UniFAR-FTUs huggingface dataset:
MicroRNA 21 targets BCL 2 mRNA to increase cell apoptosis in rat and human beta cells

Aims/hypothesis—The role of beta cell microRNA (miR)-21 in the pathophysiology of type 1 diabetes has been controversial. Here, we sought to define the context of beta cell miR-21 upregulation in type 1 diabetes and the phenotype of beta cell miR-21 overexpression through target identification. Methods—Islets were isolated from NOD mice and mice treated with multiple low doses of streptozotocin, as a mouse model of diabetes. INS-1 832/13 beta cells and human islets were treated with IL-1β, IFN-γ and TNF-α to mimic the milieu of early type 1 diabetes. Cells and islets were transfected with miR-21 mimics or inhibitors. Luciferase assays and polyribosomal profiling (PRP) were performed to define miR-21–target interactions. Results—Beta cell miR-21 was increased in in vivo models of type 1 diabetes and cytokinetreated cells/islets. miR-21 overexpression decreased cell count and viability, and increased Corresponding author: E. K. Sims, Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, 635 Barnhill Drive, MS2031, Indianapolis, IN 46202, USA, eksims@iu.edu. Data availability The datasets generated and/or analysed during the current study are available from the corresponding author on reasonable request. Duality of interest The authors declare that there is no duality of interest associated with this manuscript. Contribution statement EKS conceived and designed the experiments, acquired and analysed the data, and drafted and revised the manuscript. AL acquired and analysed the data and revised the manuscript. EAB the conceived experiments, acquired and analysed the data, and revised the manuscript. TK conceived and designed the experiments, and revised the manuscript. XT contributed to concept and design, acquired and analysed the data, and revised the manuscript. CEM contributed to conception and design, interpreted/analysed the data, and drafted and revised the manuscript. All authors gave final approval of the version to be published. EKS is responsible for the integrity of the work as a whole. HHS Public Access Author manuscript Diabetologia. Author manuscript; available in PMC 2018 June 01. Published in final edited form as: Diabetologia. 2017 June ; 60(6): 1057–1065. doi:10.1007/s00125-017-4237-z. A uhor M anscript
Title Development of an information reference system usingreconstruction models of nuclear power plants

Many nuclear power plants in Japan are approaching the end of their planned operational life spans. They must be decommissioned safely in the near future. Using augmented reality (AR), workers can intuitively understand information related to decommissioning work. Three-dimensional (work-site) reconstruction models of dismantling fields are useful for workers to observe the conditions of dismantling field situations without visiting the actual fields. This study, based on AR and work-site reconstruction models, developed and evaluated an information reference system. The evaluation consists of questionnaires and interview surveys administered to six nuclear power plant workers who used this system, along with a scenario. Results highlight the possibility of reducing time and mitigating mistakes in dismantling fields. Results also show the ease of referring to information in dismantling fields. Nevertheless, it is apparently difficult for workers to build reconstruction models of dismantling fields independently. © 2018 Korean Nuclear Society, Published by Elsevier Korea LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Magnetic circuit and speaker

The present invention relates to a magnetic circuit and a speaker, is thin and lightweight, yet, also provides a speaker and a speaker magnetic circuit, a high sound quality obtained by being a symmetrical structure with respect to the vibration direction. In the stacked three pieces of magnets (11, 12, 13), one second of the most distant and third most distant first and third magnets 11 and 13 at the same time arranged in a magnetic orientation to repel each other, the second magnet (12 of the second layer ) is disposed in the polarity, the polarity and the direction perpendicular to the upper and lower first layer and the first, the first magnet (11, 13 of the third layer). Self consisting of three layers, the circuit the second layer 2 so as to face the magnet 12 in, at both ends of the voice coil bobbin placed throughout wound voice coil 19 near the center of 18, and a voice coil bobbin (18) It binds to the same vibration system consisting of the diaphragm (14, 16) and the edge (15, 17). In this way, to realize the speaker 10 having the symmetric vibration of a center axis XX perpendicular to the central axis direction of the voice coil 19. Thin, light, vibration, symmetrical, high quality.
SIMULATION AND ANALYSES OF A GENERIC WING-BODY CONFIGURATIONS IN SUPERSONIC FLOW

Viscous and non-viscous supersonic flow simulations over a wing-body configuration are presented in this work. The numerical analysis is carried out using the Finite Element Method with an explicit one-step Taylor-Galerkin scheme and adaptive unstructured meshes employing linear tetrahedral elements. The calculations are performed with different Mach numbers (M = 2.3 and 4.63) and angles of attack (alpha = 6.2 deg and 11.1 deg). Finally, the structure of the flow field is discussed for each case and computational results are compared to available experimental data. Mecánica Computacional Vol XXVII, págs. 3119-3134 (artículo completo) Alberto Cardona, Mario Storti, Carlos Zuppa. (Eds.) San Luis, Argentina, 10-13 Noviembre 2008 Copyright © 2008 Asociación Argentina de Mecánica Computacional http://www.amcaonline. org.ar
Measuring Academic Procrastination: Scale Development and Validation Akademik Erteleme: Ölçek Geliştirme ve Doğrulama

The present study was intended to construct and validate the innovative scale to measure the academic procrastination of university students. The development and validation process was carried out in different steps. Three hundred twenty two students were selected via convenient sampling technique for carrying out the factor analysis. The results of exploratory factor analysis verified that academic procrastination can be decomposed into four factors viz: time management; task aversiveness; sincerity; personal initiative. Furthermore, investigator found evidence for convergent validity, showing that dimensions viz: time management, task aversiveness, sincerity and personal initiative were positively correlated with total score of academic procrastination scale. The internal consistency indices, alpha coefficient (0.889) is adequate for the entire academic procrastination scale. So finally results revealed that the scale possesses adequate psychometric properties. Hence it could be considered the self-administered scale assessing academic procrastination among university students.
Trends of Sampling Error in Surface Air Temperature on the Tibetan Plateau during Recent

Joint Laboratory of Climate and Environment Change/School of Atmospheric Sciences/Plateau Atmosphere and Environment Key Laboratory of Sichuan Province, Chengdu University of Information Technology, Chengdu 610225, China Key Laboratory of Meteorological Disaster (KLME), Ministry of Education & Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters (CIC-FEMD), Nanjing University of Information Science & Technology, Nanjing 210044, China Nansen-Zhu International Research Centre, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100081, China
Kinerja produksi ikan sidat Anguilla bicolor bicolor dengan pemberian kalsium karbonat Production performance of eel Anguilla bicolor bicolor with the addition of calsium carbonat

Eel have high enough prospects to cultivated. The sustainability of eel culture and overcome slowly growth arising in this cultivation was needed enough information on their biology at growth. One of the aspects that needs to be examined in an effort to increase the growth is the water quality of culture media. In addition to regulate salinity may also be convened by arranging levels of calcium and alkalinity. Calcium is an essential mineral essential required in considerable amount. The objective of the study was to determining the optimal media levels of calcium and alkalinity that can support the survival and growth of eel Anguilla bicolor bicolor and evaluate the role of calcium and alkalinity. The study was conducted with an experimental method with four treatments, the addition of dose CaCO3 on the culture media were (0, 50, 100, 150 mg/L) and repeated three times. Aquariums for fish maintenance were insulated form in the size of 100×50×40 cm3 and with recirculation system. Insulation serves to separate the filter and maintenance parts. The filter used as a physical, chemical, and biology filters. The parameters measured were the survival rate, growth rate on biomass, feed convertion ratio, oxygen consumption rate, and the employment rate of osmotic. The results of this study showed treatment with 50 mg/L calcium carbonate addition into the culture media was the best treatment for growth rate of 1.77 g/day and optimal feed convertion ratio of 2.27, oxygen comsumption rate of 0.41 mg O2/g/h and osmotic work rate of 0.269 mOsm/L H2O.
Phytochemicals Screening, Antioxidantand Anticancer Activities of Garlic (Allium sativum) Extracts

The objective of this study is to determine the phytochemicals of garlic, antioxidants and anticancer activities against cancer cell line (MCF-7) of hot water, cold water and ethanol extracts of garlic (Allium Sativum). The results showed that garlic contains more than 80% total carbohydrates and proteins. Also, qualitative phytochemical analysis of garlic extracts indicated the presence of flavonoids, alkaloids, tannins, phenols, saponins, terpenoids, steroids and phytosterols in ethanol and hot water extracts, whereas alkaloids and saponins are absent in cold water extract. Moreover, antioxidant activity of garlic extracts by DPPH method showed a strong effect on the activity scavenging of free radicals. In addition, ethanol extract had higher reducing power, total flavonoids and total phenolics contents in comparison with hot water and cold water extracts. Finally, garlic extracts also showed very high cytotoxic activity against human breast cancer cell line type (MCF-7) especially ethanol extract, which makes us recommend that garlic is useful as a rich antioxidant and has great strength against cancer cells.
Testing Pecking Order Theory and Market Timing Theory in the Egyptian Stock Exchange

The present study aims at testing the pecking order theory and the market timing theory and how they explain the capital structure decisions of firms listed in the Egyptian stock exchange. The paper examines each theory, independently in separate models and examines both theories, collectively in one model. Both approaches are conducted using panel data analysis for a sample of 43 firms listed on the Egyptian stock exchange in different industrial sectors over the period 2009-2015. The results indicated that the modified pecking order theory is the best theory to explain the capital structure decisions in Egypt, while the market timing has short term effect on capital structure. The study also showed that the most important determinants of capital structure in Egypt are profitability, firm size, growth and financial deficit. The study also confirms the arguments of the capital structure theories are not mutually exclusive and they complete each other in explaining the capital structure decisions
1 Subsidized and non-subsidized R & D projects : Do they differ ?

Little is known about whether and to what extent the outcome of subsidized and non-subsidized R&D projects differ. In this paper we exploit a novel dataset of patent applications filed in Germany between 1995-2005, which allows us to identify if a patent application stems from a subsidized project or not. We use a variety of patent indicators to elucidate to what extent successful subsidized and non-subsidized R&D projects differ. Results show that patent applications from subsidized R&D projects have a higher private value, are more often co-applied, more general, but less original, and have larger inventor teams when compared to all other patent applications filed by the same firms. These differences seem to reflect that thematic R&D programs aim to support R&D projects that have an immediate economic utilization of results and in which firms collaboratively develop basic technologies in high-tech fields. JEL: H25, O31, O34, O38, H50
Examining dimensionality and interdependencies in the design of service innovation

Service innovation is increasingly recognized as the design of multidimensional and complex systems. Accordingly, there is a need for comprehensive and validated conceptualizations, as well as an enhanced understanding of the interdependencies between the dimensions making up the service. Promising in this respect is the potential of applying complex systems theory in the form of the NK-model, based on an evolutionary interpretation of innovation. In this analytical structure, new offerings are interpreted as emerging from adaptive search processes. Which strategy is appropriate for modifying a certain service is argued to depend on characteristics of the design space a firm is facing. By demonstrating the applicability of the NK-model in the context of intangible products, we aim to advance the multidimensional approach to service innovation. We explore the dimensionality and interdependencies of 13 qualitatively studied service innovations by mapping each of them on one single multidimensional conceptualization. Whereas some cases support the claim that services are associated with ill-defined design spaces, we argue that familiarity with common elements, and archetypical modifications therein, might provide valuable guidance to service innovators. Furthermore, the observed dimensionality points at intermediate degrees of interdependency and ways to use modularity for dealing with this. Jelcodes:O31,-
Dutilleux and Müller-Tomfelde Spatial Sound Reproduction and Applications

A museum-exhibit gives the visitors an opportunity to experience the relation between sounds and performance space. The impulse responses of real rooms have been measured and a simulator (Spatialisateur) has been programmed to imitate these spaces. Elementary volumes are imitated using simpler algorithms. A tracking system enhances the spatial illusion by compensating for the movements of the listener’s head.
Molecular phylogenetic analysis of Cysticercus ovis from Egypt based on MT-CO 1 gene sequences

Cysticercus ovis or sheep measles is the larval stage of Taenia ovis, which is the intestinal tapeworm of dogs. It is found in the cardiac and skeletal muscles of sheep and can be the cause of partial or total condemnation of carcasses at abattoirs. The aim of the current work was to determine the prevalence of C. ovis among sheep in Upper Egypt and to present the molecular and phylogenetic analysis of this using the amplified Mitochondrial Cytochrome Oxidase subunit 1 (MT-CO1) gene. A total of 1885 sheep slaughtered at local abattoirs of 4 different governorates of Upper Egypt (Asuit, Sohag, Qena and Aswan) were carefully examined for C. ovis. The overall prevalence of infection was 2.02%. The highest rate of infection was observed in adult animals over 4 years of age (44.73%). There was no significant effect of animal sex on infection rates. The phylogenic analysis of C. ovis Egyptian isolates showed very close similarity to the New Zealand isolate (AB731675). This is the first report showing the genetic analysis of C. ovis in Egypt, which provides a very powerful tool for taxonomy and definitive diagnosis of C. ovis, which could be helpful for preventive and control programs.
Soil-Moisture Dynamics Using Travel-Time Distributions

Travel-time distributions are a comprehensive tool for the characterization of hydrological system dynamics. Unlike stream ow hydrographs, they describe the movement and storage of water inside and through the hydrological system. Until recently, studies using such travel-time distributions have generally either been applied to simple (arti cial toy) models or to real-world catchments using available time series, e.g. ✿ , stable isotopes. Whereas the former are limited in their realism, 5 the latter are limited in their use of available data sets. In our study, we employ a middle ground by using the mesoscale Hydrological Model (mHM) and apply it to a catchment in Central Germany. Being able to draw on multiple large data sets for calibration and veri cation, we generate a large array of spatially distributed states and uxes. These hydrological outputs are then used to compute the travel-time distributions for every grid cell in the modeling domain. A statistical analysis shows the general soundness of the upscaling scheme employed in mHM and reveal precipitation, saturated soil moisture and po10 tential evapotranspiration as important predictors for explaining the spatial heterogeneity of mean travel times. In addition, we demonstrate and discuss the high information content of mean travel times for characterization of internal hydrological processes.
Primjena PSO algoritma u estimaciji parametara transformatora

U ovom radu je razmatrana upotreba Particle Swarm Optimization algoritma u estimaciji parametara transformatora. Estimirani parametri zamjenske šeme rezultat su procesa minimizacije razlike između estimiranih i izmjerenih vrijednosti odgovarajućih električnih veličina. U cilju određivanja parametara transformatora korišćene su vrijednosti struje primara i vrijednosti napona i struje sekundara. Dobijeni rezultati upoređeni su sa rezultatima dobijenim pomoću klasične metode za određivanje paramatera mašine, a koja se bazira na izvođenju ogleda praznog hoda i kratkog spoja. Zaključeno je da PSO algoritam predstavlja veoma efikasan metod za estimaciju parametara transformatora. Ključne riječi: transformator, zamjenska šema, parametri, PSO algoritam
Embedded FFT with dsPIC 30 F 4013

FFT-based digital spectral analyzer has become more widely used as a result of the development of Digital Signal Processing (DSP) techniques. Modern Analog-to-Digital Converters (ADC) and processors have made it possible to make fast measurements with a limited number of hardware. In this paper, a design of a simple low-cost FFT-based digital spectrum analyzer was presented. The author discusses the design of each components of the system in qualitatively and quantitatively. The report presents the whole system design in detail which contains filter design, microcontroller design and UART transmission design. Some satisfying measurement result of the system were presented in the paper. The system can provide fast measurement with good accuracy but the measured result has a limited range and resolution of the display is not very high. At last, the advantages and disadvantages of the system was discussed which is considered as guidelines for further work. Keywords— FFT, Digital Signal Processing, spectrum analyzer.
THE CASE OF INTANGIBLE ASSETS IN THE ITALIAN MARKET A

Disclosure of financial statements is an important topic both for investors and for preparers as disclosure allows investors to understand the application of the accounting principles used by companies. This research examines the 2010 financial statements under IFRS of 189 Italian listed groups and their compliance with mandatory disclosure on intangible assets and presents an in depth empirical analysis of the Italian market – that belongs to the Continental European accounting cluster. Different variables were tested to analyze the compliance with the mandatory disclosure such as size variables, performance variables, financial interest variables and market variables. Many studies on mandatory disclosure are based on one disclosure index method and results are affected by the different approaches used: Cooke’s dichotomous approach, Partial Compliance method, weighted and unweighted. In this paper, the decision was taken to run all the previous methods: results show that the only significant variable for all Dscore indexes is the weight of interests on revenues and this result is a distinctive feature of the Italian market where the role of the banking systems is more important than in other countries.
Explorer Discovering Graph Functional Dependencies

This paper studies discovery of GFDs, a class of functional dependencies defined on graphs. We investigate the fixed-parameter tractability of three fundamental problems related to GFD discovery. We show that the implication and satisfiability problems are fixed-parameter tractable, but the validation problem is co-W[1]hard. We introduce notions of reduced GFDs and their topological support, and formalize the discovery problem for GFDs. We develop algorithms for discovering GFDs and computing their covers. Moreover, we show that GFD discovery is feasible over large-scale graphs, by providing parallel scalable algorithms for discovering GFDs that guarantee to reduce running time when more processors are used. Using real-life and synthetic data, we experimentally verify the effectiveness and scalability of the algorithms.
Migration and Local Development : The Multiplier Effect of Migrant Remittances on Non-recipient Households in Tsholotsho , Zimbabwe

Substantial policy and academic research on migration has focussed on migrant remittances to developing countries. That research has often given a positive evaluation of the impact of remittances on development, with specific reference to recipient households. However, there is limited research examining the indirect effect of migrant remittances on the development emanating from the activities of non-recipient households. Given the research gap, this paper seeks to examine the extent to which non-recipient households benefit from the flow of income and other material goods into their local economy. This study is based on a questionnaire survey (N = 159) and 15 semi-structured interviews. A key finding was that remittances have partly motivated the emergence of an entrepreneurial spirit in the local economy, with most of the local small businesses (including general dealer stores, bed and breakfast accommodation, construction companies etc.) run by non-recipient households. Non-recipient households have emerged as key entrepreneurial players in response to a high consumption demand amongst the recipient households. Profits generated through these small businesses are thus satisfying the basic needs of nonrecipient households. Furthermore, a number of community projects are being financed through remittance income. These projects include food gardens, fishing and livestock farming which benefit both the recipient and non-recipient households.