Miracle-dz/UniFAR-FTUs huggingface dataset:
A Wearable Pneumatic Device for Investigating Ankle Inversion and Eversion in Human Gait

Human walking has been a highly studied topic in research communities because of its extreme importance to human functionality and mobility. A complex system of interconnected gait mechanisms in humans is responsible for generating robust and consistent walking motion over unpredictable ground and through challenging obstacles. One interesting aspect of human gait is the ability to adjust in order to accommodate varying surface grades. Typical approaches to investigating this gait function focus on incline and decline surface angles, but most experiments fail to address the effects of surface grades that cause ankle inversion and eversion. There have been several studies of ankle angle perturbation over wider ranges of grade orientations in static conditions; however, these studies do not account for effects during the gait cycle. Furthermore, contemporary studies on this topic neglect critical sources of unnatural stimulus in the design of investigative technology. It is hypothesized that the investigation of ankle angle perturbations in the frontal plane, particularly in the context of inter-leg coordination mechanisms, results in a more complete characterization of the effects of surface grade on human gait mechanisms. This greater understanding could potentially lead to significant applications in gait rehabilitation, especially for individuals who suffer from impairment as a result of stroke. A wearable pneumatic device was designed to impose inversion and eversion perturbations on the ankle through simulated surface grade changes. This prototype device was fabricated, characterized, and tested in order to assess its effectiveness. After testing and characterizing this device, it was used in a series of experiments on human subjects while data was gathered on muscular activation and gait kinematics. The results of the characterization show success in imposing inversion and eversion angle perturbations of approximately 9° with a response time of 0.5 s. Preliminary experiments focusing on inter-leg coordination with healthy human subjects show that one-sided inver-
Odometry correction of a mobile robot using a range-finding laser

Two methods for improving odometry using a pan-tilt range-finding laser is considered. The first method is a one-dimensional model that uses the laser with a sliding platform. The laser is used to determine how far the platform has moved along a rail. The second method is a two-dimensional model that mounts the laser to a mobile robot. In this model, the laser is used to improve the odometry of the robot. Our results show that one-dimensional model proves our basic geometry is correct, while the two-dimensional model improves the odometry, but does not completely correct it.
The Effectiveness of Cognitive , Metacognitive , and Behavioral Model on Reducing Anxious Thoughts in Patients with Social Anxiety Disorder

Introduction: This study was conducted in order to examine the effectiveness of cognitive, metacognitive, and behavioral model on the reduction of anxious thoughts in patients with social anxiety disorder. Methods: The study method was semi-experimental with a pre-posttest design and a control group. The statistical population contained all the patients with social anxiety disorder referring to public and private centers in Kermanshah in 2016 which were selected using available sampling method. A total of 30 patients who were chosen through structured interviews (SCID-I), and Well’s Questionnaire of Anxious Thoughts (1994), were randomly divided into two experimental and control groups. Twelve cognitive, meta-cognitive, and behavioral therapy sessions due to the developed model and on the basis of relevant theoretical insights was done twice a week for the experimental group while the control group received no interventions. After the treatment, both groups were evaluated with the test. For data analysis, one-way covariance (ANCOVA) was used. Results: The findings showed that cognitive, meta-cognitive, and behavioral developed model has been effective on the reduction of anxious thoughts among patients with social anxiety disorder in the experimental group (P<0.001). Conclusion: Considering the effectiveness of the model, it seems that therapists and counselors can use this developed model to reduce anxious thoughts among patients with social anxiety disorder.
Essential oil constituents and in vitro antimicrobial activity of the root of Mondia whitei (Hook. F.) Skeels (Periplocaceae)

The composition of the essential oil of the root of Mondia whitei was analysed by gas chromatography-mass spectrometry (GC/MS). The agar-well diffusion technique was used for the antimicrobial assay of the oil against nine clinical pathogenic organisms viz. Bacillus cereus, Escherichia coli, Candida albicans, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Salmonella typhi, Staphylococccus aureus and Streptococcus pyogenes. Twenty-eight compounds representing 99.92% of the essential oil were characterized. The major constituents of the oil were (E)-2-hexen-1-ol (25.96%), heptacosane (20.94%), phytol (15.60%), 1-hexanol (8.94%), (E)-2-hexenal (4.29%) and 2-hydroxy-p-anisaldehyde (4.21%). At 106 cfu/ml inoculums concentration, the oil was most active against E. coli (50.0 mm) and S. aureus (48.3 mm) and least active on C. albicans (15.0 mm). Generally, the oil exhibited significant (P ≤ 0.05) antimicrobial activity against the test organisms. The observed antimicrobial activity justify the ethnomedicinal uses of M. whitei in Nigeria. Key words: Essential oil, Mondia whitei, root, (E)-2-hexen-1-ol, pathogenic organisms, antimicrobial assay.
Gadolinium EnhancedMR Coronary Vessel Wall Imaging at 3 . 0 Tesla

1 Department of Medicine/Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, Germany 2 Division of Magnetic Resonance Research, Department of Radiology, Johns Hopkins University, School of Medicine, 601 North Caroline Street, Baltimore, MD 21287, USA 3 Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205-2196, USA 4 Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21205-2196, USA
Effect of Inhibition of Cytochrome P 450 Enzymes 2 D 6 and 3 A 4 on the Pharmacokinetics of Intravenous Oxycodone A Randomized , Three-Phase , Crossover , Placebo-Controlled Study

Background and Objective: Oxycodone is a m-opioid receptor agonist that is mainly metabolized by hepatic cytochrome P450 (CYP) enzymes. Because CYP enzymes can be inhibited by other drugs, the pharmacokinetics of oxycodone are prone to drug interactions. The aim of this study was to determine whether inhibition of CYP2D6 alone by paroxetine or inhibition of both CYP2D6 and CYP3A4 by a combination of paroxetine and itraconazole alters the pharmacokinetics of and pharmacological response to intravenous oxycodone. Methods: We used a randomized, three-phase, crossover, placebo-controlled study design in 12 healthy subjects. The subjects were given 0.1mg/kg of intravenous oxycodone after pre-treatments with placebo, paroxetine or a combination of paroxetine and itraconazole for 4 days. Plasma concentrations of oxycodone and its oxidative metabolites were measured over 48 hours, and pharmacokinetic and pharmacodynamic parameters subsequently evaluated. Results: The effect of paroxetine on the plasma concentrations of oxycodone was negligible. The combination of paroxetine and itraconazole prolonged the mean elimination half-life of oxycodone from 3.8 to 6.6 hours (p < 0.001), and increased the exposure to oxycodone 2-fold (p < 0.001). However, these changes were not reflected in pharmacological response. Conclusion: The results of this study indicate that there are no clinically relevant drug interactions with intravenous oxycodone and inhibitors of CYP2D6. If both oxidative metabolic pathways via CYP3A4 and 2D6 are inhibited the exposure to intravenous oxycodone increases substantially. ORIGINAL RESEARCH ARTICLE Clin Drug Investig 2011; 31 (3): 143-153 1173-2563/11/0003-0143/$49.95/0 a 2011 Adis Data Information BV. All rights reserved.
Cross-cultural cooperation in The Netherlands: A Damoclian sword

The paper studies cross-cultural cooperation between black Curacaoans and white Dutch in the Netherlands. It shows that while respondents share the same cultural characteristics, the way they handle these and the way they value both their own traits and those of the other group differ with the specific context in which cooperation takes place. Culture is shown to be a more flexible and dynamic concept than is commonly used in the more static approach of standardized, universalistic cultural differences, which still prevail in management thinking on cross-cultural cooperation. "All the world"s a stage, and all the men and women merely players. They have their exits and their entrances, and one man in his time plays many parts. " (Shakespeare 1598: 42)
INFLUENCE OF LEVELS OF FRUIT AND SUGAR ON CHEMICAL COMPOSITION OF POMEGRANATE YOGHURT

The influence of addition of pomegranate fruit and sugar levels on chemical composition of pomegranate yoghurt was studied. It was observed that addition of fruit arils (grains) @ 10-15 per cent before incubation in unstirred form with addition of 3-6 per cent sugar was more acceptable. The best pomegranate yoghurt contained 3.20 per cent fat, 21.20 per cent T.S. , 5.76 per cent reducing sugar, 13.53 per cent total sugar, 1.09 per cent acidity and pH 4.52. The cost of production of most acceptable pomegranate yoghurt containing 10 per cent fruit arils and 6 per cent sugar was Rs. 28.41/kg.
Form-function rules in the first words stage: A longitudinal study of two children.

This work analyzes pragmatic development in the first words stage, specifically the form-function rules that infants construct for communicating. It presents data from two children who took part in a longitudinal/observational case study research. Our results point to the general tendencies identified with respect to form-function rules (Ninio, 1994b; Ninio & Snow, 1996) and to the existence of inter-individual differences. These differences refer to: a) the mapping of form-function rules and b) pragmatic flexibility. Differences in early lexical acquisition are related to the children’s general communicative profiles.
Rapid and brief communication 2 Dclustering based discriminant analysis for 3 Dheadmodel classification

This paper introduces a novel framework for 3D head model recognition based on the recently proposed 2D subspace analysis method. Two main contributions have been made. First, a 2D version of clustering-based discriminant analysis (CDA) is proposed, which combines the capability to model the multiple cluster structure embedded within a single class with the computational advantage that is characteristic of 2D subspace analysis methods. Second, we extend the applications of 2D subspace methods to the field of 3D head model classification by characterizing these models with 2D feature sets. 2005 Pattern Recognition Society. Published by Elsevier Ltd. All rights reserved.
Cytocidal effects of acridine orange evoked by blue light on human bladder cancer cells

Objectives: Bladder cancer is a major malignancy in urology, and has a high rate of recurrence. Intravesical BCG instillation therapy, despite many adverse effects, is often used to prevent recurrence. Acridine orange (AO), a membrane permeable weakly basic dye, has cytocidal effects when the blue light is illuminated. For this reason, AO was used for the photodynamic therapy (PDT) of musculoskeletal sarcoma. In order to test if AO-PDT can become an effective treatment for bladder cancer, we wanted to determine the cytocidal effects of AO evoked by blue light on the human bladder cancer cell line T-24. Methods: T-24 cells loaded with AO were observed during blue light illumination under a fluorescent microscope, and vesicle disruption and cell death were assessed by trypan blue staining. To determine the cytocidal mechanism, we determined the change of vesicle disruption and cell death using bafilomycin A1, a vacuolar H + -ATPase inhibitor, and antioxidants, and intracellular distribution of cathepsin D, a lysosomal protease, was also investigated. Finally, the efficacy of the evoked AO on normal rat bladder cells was compared to that on T-24 cells. Results: Cells showed the disruption of AO-containing vesicles as a green flash during blue light illumination and died within 30 minutes. Bafilomycin A1 and antioxidants inhibited vesicle disruption and cell death. Intravesicular cathepsin D increased in the cytoplasm following illumination. Normal bladder cells showed slight vesicular AO accumulation but did not die in the same condition that almost all T-24 cells died. Conclusions: AO evoked by blue light has strong cytotoxicity for the T-24 bladder cancer cells and was caused by the lipid peroxidation-mediated disruption of vesicles, where AO is accumulated by vacuolar H + -ATPase, followed by the subsequent release of cathepsin D into the cytoplasm. PDT with AO may be worthwhile for the treatment of bladder cancer.
Time domain Frequency domain Activity signal Feature extraction Model training Mean Variance Amplitude

Sensor-based activity recognition seeks the profound high-level knowledge about human activities from multitudes of low-level sensor readings. Conventional pattern recognition approaches have made tremendous progress in the past years. However, those methods often heavily rely on heuristic hand-crafted feature extraction, which could hinder their generalization performance. Additionally, existing methods are undermined for unsupervised and incremental learning tasks. Recently, the recent advancement of deep learning makes it possible to perform automatic high-level feature extraction thus achieves promising performance in many areas. Since then, deep learning based methods have been widely adopted for the sensor-based activity recognition tasks. This paper surveys the recent advance of deep learning based sensor-based activity recognition. We summarize existing literature from three aspects: sensor modality, deep model, and application. We also present detailed insights on existing work and propose grand challenges for future research.
CDR content 14-1

DOI: 10.2174/1573399812666160629094031 Abstract: Introduction: Beta-cell replacement by human islets or whole pancreas offers a life-saving therapeutic remedy for patients suffering from type 1 diabetes, providing considerable advantages with respect to diminishing total daily insulin dose and lowering frequencies of debilitating hypoglycemic reactions as well as preventing chronic microand macrovascular complications. Although remarkable progress has been made in this area, several hurdles remain, hampering its wide-spread applicability. Such hurdles include a limiting supply of islets, the necessity of several donors to achieve enough islet mass for insulin independence, and graft failure because of metabolic pressure, continued autoimmunity, alloimmunity, high concentrations of immunosuppressive drugs as well as oxidative stress caused by hypoxia or inflammation. On the other hand, the islet transplant procedure provides the possibility to undertake multiple practical and beneficial manipulations of the beta cells before engraftment with the intention to reach improved graft survival results.
Exchange Rates and Cash Flows in Differentiated Product Industries: A Simulation Approach

How do exchange rate changes impact firms' cash flows? We extend a simulation method developed in industrial organization to answer this question. We use prices, quantities, and product characteristics for differentiated products, coupled with a discrete choice framework and an assumption of price competition, to estimate marginal costs for all producers. Using a Monte Carlo approach we generate counterfactual prices and profits for different levels of exchange rates. We illustrate the method using the market for bottled water. Our results stress that even in a relatively simple market such as this one, different brands face very different exchange rate risks. Copyright 2007 by The American Finance Association.
An evaluation of adult safeguarding outcomes’ focused recording in the context of Making Safeguarding Personal

Purpose – The purpose of this paper is to evaluate the impact in one local authority of Making Safeguarding Personal (MSP) upon the recording of outcomes in safeguarding interventions. To determine to what extent person centred outcomes were in evidence. Design/methodology/approach – Analysis of data provided by the local authority across adult safeguarding teams informed by a critical theory approach. Findings – There is a need for cultural and system change to fully embed MSP principles within local authority safeguarding. This case study identified that practitioner recording was inconsistent with the need for greater recognition of person centred approaches within adult safeguarding. Views of the service user are constructed and moderated by the assessing professional and the user voice is seldom evident in recording of safeguarding interventions. Research limitations/implications – This study was wholly reliant upon the data provided rather than primary investigations with practitioners and service u.
FastRobustMethods for Singular State-SpaceModels

State-space models are used in a wide range of time series analysis applications. Kalman filtering and smoothing are work-horse algorithms in these settings. While classic algorithms assume Gaussian errors to simplify estimation, recent advances use a broad range of optimization formulations to allow outlier-robust estimation, as well as constraints to capture prior information. Here we develop methods on state-space models where either transition or error covariances may be singular. These models frequently arise in navigation (e.g. for ‘colored noise’ models or deterministic integrals) and are ubiquitous in auto-correlated time series models such as ARMA. We reformulate all state-space models (singular as well as nonsingluar) as constrained convex optimization problems, and develop an efficient algorithm for this reformulation. The convergence rate is locally linear, with constants that do not depend on the conditioning of the problem. Numerical comparisons show that the new approach outperforms competing approaches for nonsingular models, including state of the art interior point (IP) methods. IP methods converge at superlinear rates; we expect them to dominate. However, the steep rate of the proposed approach (independent of problem conditioning) combined with cheap iterations wins against IP in a run-time comparison. This suggests that the proposed approach can be a default choice for estimating state space models outside of the Gaussian context for singular and nonsingular models. To highlight the capabilities of the new framework, we focus on navigation applications that use singular process covariance models. The methods have been implemented in an open source Python code.
Morphological Plasticity of Dominant Species in Response to Nutrients Dynamics in Bidighinzu Reservoir of Sardinia, Italy

The aim of this study was to describe the effect of environmental factors on the variation in population structure of phytoplankton in a hypertrophic reservoir and to analyse the size variability of dominant species, and finally to try to find a linkage between environmental factors and phytoplankton size structure. Species composition and dynamics of phytoplankton were typical of highly trophic conditions and were frequently characterized by the dominance of cyanobacteria, Microcystis, Anabaena, Aphanizomenon. Some environmental parameters play an important role in determining the phytoplankton community succession and their size structure, favouring or limiting the growth of the different groups of the phytoplankton. The results indicate that overall nutrient concentrations in Bidighinzu Lake were not limiting the phytoplankton growth in general. On the contrary, concentrations of nutrient were always above the required levels for phytoplankton growth. The results show that phytoplankton community succession and their seasonal variability of size structure (consequently cell surface area, cell volume and surface area to volume ratio) were mostly influenced by the temperature and nutrients. However, these affecting factors (especially nutrients) on seasonal variability of size structure of common species in Lake Bidighinzu showed difference among the species.
Biofilm formation and antimicrobial resistance in Klebsiella pneumoniae isolated from patients visiting a tertiary care center of Nepal

Hari Prasad Nepal, Puja Neopane, Rojeet Shrestha, Rajendra Gautam, Rama Paudel, Shamshul Ansari, Sony Shrestha, Sangita Thapa Department of Microbiology, Trinity School of Medicine, Ratho Mill, St. Vincent and the Grenadines Division of Oral Medicine and Pathology, Health Sciences University of Hokkaido, Tobetsu, Japan Department of Microbiology, Chitwan Medical College and Teaching Hospital, Bharatpur, Nepal Faculty of Health Sciences, Hokkaido University, Sapporo, Japan Department of Pharmacology, Universal College of Medical Sciences, Bhairahawa, Nepal Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Oita, Japan Asian Pac J Trop Dis 2017; 7(6): 347-351
Effect of Insulin Glargine and n-3 FA on Carotid Intima-Media Thickness in PeopleWithDysglycemiaatHighRiskfor Cardiovascular Events The Glucose Reduction and Atherosclerosis Continuing Evaluation Study ( ORIGIN-GRACE )

RESEARCHDESIGNANDMETHODSdWe enrolled 1,184 people with cardiovascular (CV) disease and/or CV risk factors plus impaired fasting glucose, impaired glucose tolerance, or early type 2 diabetes in a randomized multicenter 23 2 factorial design trial. Participants received open-label insulin glargine (targeting fasting glucose levels#5.3 mmol/L [95 mg/dL]) or standard glycemic care and double-blind therapy with a 1-g capsule of n-3FA or placebo. The primary trial outcomewas the annualized rate of change inmaximumCIMT for the common carotid, bifurcation, and internal carotid artery segments. Secondary outcomes were the annualized rates of change in maximum CIMT for the common carotid and the common carotid plus bifurcation, respectively. Baseline followed by annual ultrasounds were obtained during a median follow-up of 4.9 years.
Interactive comment on “ Recent changes in terrestrial water storage in the Upper Nile Basin : an evaluation of commonly used gridded GRACE products ” by Mohammad Shamsudduha

Response to Anonymous Referee 1 (AR1) Numbered responses are given below each comment: [AR1] This study aims to estimate the TWS change and its individual components in the Upper Nile Basin using GRACE, LSMs and in situ observations. Actually, similar studies have been done in this region by Awange et al. [2013], Awange et al. [2014], and Nanteza et al. [2016]. So, the main point is whether this manuscript can bring enough new knowledge based on new/updated data or methods. Different from previous studies, three different GRACE products (gridded level-3 GRCTellus, JPL mascon