Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of the allelic variability of BmVDAC and Subolesin, two vaccine candidates against Rhipicephalus microplus in isolates from Mexico

Introduction: Rhipicephalus microplus ticks are hematophagous ectoparasites that economically impact lifestock industry worldwide. Acaricides have been an effective control strategy, but generate resistance to chemical compounds and environmental pollution. An alternative to counteract the chemical adverse effects is the vaccination usage, which is effective, environmentally friendly and unexpensive. However, still anti-tick vaccines present variable efficacy due to possible differences in aminoacid sequences within tick antigens from geografically distinct isolates. The aim of this work was to analyze the variability of two vaccine antigens: BmVDAC (Voltage Dependent Anion Channel) and Subolesin from R. microplus isolates from different states of Mexico. Methods: Two proteins were selected based on its efficacy as protective antigens: BmVDAC and Subolesin. R. microplus ticks was collected from different states of Mexico. Isolation of both DNA and RNA was performed to amplify bmvdac and subolesin respectively. Predicted amino acid sequences were obtained. A BLAST analysis was carried out to confirm the identity within sequences and determine similarity by an alignment using Clustal Omega. Finally, to determine the phylogenetic relationship of each isolate an analysis by MEGAX64 software was performed. Results: For BmVDAC, an average percentage of 99.79% identity and similarity was observed within the different aminoacid sequences. In the isolates from Chiapas, Nayarit, Media Joya, Queretaro, Tamaulipas and Guerrero a similarity and identity percentage of 99.87% was observed. Jalisco, Tabasco and Sinaloa a similarity and identity percentage of 99.56% was presented. On average, a variability percentage of 0.21% was observed. The Subolesin alignment with isolates from Yucatan, Nayarit, Queretaro, Chiapas, Sinaloa, Veracruz, Tamaulipas, and the reference Munoz strain, an identity average percentage of 99.87% and similarity percentage of 100% was observed in the aminoacid sequences. Seven from eight sequences presented identity percentage of 99.91% whereas for Nayarit the percentage was 99.39%. The average variability was 0.13%. Phylogenetic analysis did not show significant differences between sequences using the UPGMA method. Average percentage obtained by 10000 replicas by Bootstrap method for bmvdac and subolesin was up to 50%. Discussion and conclusion . This report represents the first research on the characterization of the variability for BmVDAC and Subolesin, two vaccine antigens against R. microplus isolates from different states of Mexico. Considering the low variability presented by the different R. microplus isolates sequences, we can conclude that BmVDAC and Subolesin are antigens that are conserved and can be considered as vaccine candidates. This information is relevant for antigen selection and vaccine design against R. microplus in Mexico.
The Effectiveness and Safety of 1% Silver Sulfadiazine (Flammazine)Cream in Preventing Infection in Potentially Contaminated TraumaticWounds among Pediatric Patients 2 To <18 Years Old: An Open-Label,Single-Arm Phase 3 Clinical Trial

This is an open label, descriptive, single-arm study of patients, 2 to <18 years of age conducted at the out-patient department, Research Institute for Tropical Medicine (RITM), the primary objective of which is to evaluate the effectiveness and safety of silver sulfadiazine in preventing infection in potentially contaminated traumatic wounds among children 2 to <18 years of age. All of the 50 subjects enrolled had contaminated wound upon enrolment, without oral antibiotics and other topical medications previously used. After seven days of Flammazine application, 100% had clinical successand after 14 days of application, 100% of the subjects likewise had persistent clinical success. At baseline, the most common criteria present was pain (96%) followed by erythema (94%). 58% had mild itching, and 56% had mild tissue edema. Overall, the SIRS (Severity of Infection Rating Scale) scores improved after 7 days (100%) and 100% of the subjects had SIRS score of 0 after 14 days. The study has shown that 1% Silver Sulfadiazine appears to be an effective and safe alternative to antibiotics in the management of wound infections which are potentially contaminated among children 2 to <18 years of age.
Absolute atomic hydrogen density measurements in an atmospheric pressure plasma jet: generation, transport and recombination from the active discharge region to the effluent

Atomic hydrogen (H) generated by an atmospheric pressure radio frequency (RF) plasma jet is investigated by two-photon absorption laser induced fluorescence in a He–H2 mixture. The reported time and spatially resolved H density profiles enable a detailed analysis of the species generation, transport and decay along the axis of symmetry of the jet. The H density distribution for a continuous RF plasma jet corresponds well with the outcome of a Pseudo-1D plug flow model. In addition, RF power modulation has a strong effect on the H density in the active discharge region but has a negligible effect on the H density in the far effluent.
Global warming opens the door for invasive macrophytes in Swedish lakes and streams

Global warming opens the door for invasive macrophytes in Swedish lakes and streams The increased travelling and transporting by man has caused more species to be moved to new areas, e.g. in ballast water. These species are called introduced species or alien species. Some alien species manage to reproduce and grow rapidly in their new environment. They are then called invasive species. Invasive species is a threat against biodiversity and an economical problem. They compete with other species and can change the environment for these species. In this study aquatic plants (macrophytes) are treated. Some invasive macrophytes have such an immense growth that they are an obstacle for swimmers and anglers. Examples of aquatic species that has been introduced to Sweden and caused problems are the water weed (Elodea canadensis) and the fringed water lily (Nymhopides peltata). Due to the emissions of so called greenhouse gases, the scientist believes that the climate is changing. They estimate that the annual mean temperature in Sweden will rise with 2.5–4.5°C. The consequences are that species that previously was not able to survive in Sweden might be able to survive in the future. In this study I have compiled a list of aquatic vascular plants introduced somewhere in the world. I have examined if the species described as invasive could establish in Sweden, both at the current climate, and in the future climate predicted by two different models from the Swedish Metrology and Hydrology Institute (SMHI). By matching the species distribution with current climate using the computer program GARP (Genetic Algorithm for Rule-set Prediction), I have created a niche for each species. These niches have been projected onto the future and current climate. The results show that the risk of introductions of invasive species to Swedish freshwater habitats will increase in the future. Many of the invasive species are also able to establish at the current climate. The results show that the species which have the biggest possibility to establish in Sweden are: Azolla filiculoides, Crassula helmsii, Lagarosiphon major, Lemna minuta, Myriophyllum aquaticum and Zizania aquatica. They can establish at both the current climate, and a future warmer climate.
Investigating the PDR process in a UK university: continuing professional development or performativity?

ABSTRACT Over recent years, the professional development review process has risen in importance in universities with such exercises being shown to have a positive effect on student learning, staff motivation, recruitment and retention. However, they may also be perceived as a controlling mechanism and part of a culture of ‘performativity’, which implies a lack of trust, an undermining of autonomy and a reliance on externally driven targets to ‘manage’ staff. However, there is very little published research in this area. This paper addresses this knowledge gap by drawing on data from a Leadership Foundation funded study in a UK University which included 30 interviews and a follow-up survey (n = 177) with both leaders and the staff they lead. The findings suggest that both leaders and staff felt that the process was potentially very important and could offer significant levels of guidance and support for professional development. However, they stressed the importance of a review structure which was adaptable, more professionally relevant, and less reliant on over-ambitious target setting.
Anaesthetic experience of 200 renal transplantation cases: A retrospective study

Özet Abstract GİRİŞ ve AMAÇ: Böbrek nakli son dönem böbrek yetmezliği tedavisinde en iyi tedavi şeklidir. Anestezi yönetimi preoperatif, postoperatif ve intraoperatif dönem boyunca iyi planlanmalıdır. Böbrek nakli ile ilgili olarak birçok çalışma yapılmıştır. Bunlardan bazıları anestezi tekniklerini incelemiş olup bazıları anestezik ilaçların hasta ve nakil edilen böbrek üzerine etkilerini incelemişlerdir. Biz bu çalışmada böbrek nakli gerçekleştirilen 200 hastanın anestezi yönetimleriyle ilgili deneyimlerimizi sunmayı amaçladık. YÖNTEM ve GEREÇLER: Verileri elde etmek için hasta dosyaları kullanıldı. BULGULAR: Anestezi indüksiyonunda intravenöz ajanlardan propofol (2 mg/kg), fentanil (2-3 μgr/kg) ve kas gevşetici olarak roküronyum (0.6 mg/kg) veya atraküryum (0.6 mg/kg) kullanıldı. Operasyonda anestezi idamesi için % 1-2 izofluran (n: 67), % 1-2 sevofluran (n: 49), % 6-7 desfluran kullanıldı. İntraoperativ analjezik olarak remifentanil (0.25-0.5 μgr/kg/min) kullanıldı. Ortalama cerrahi süre 3.18 (±0.64 SS) saat, ortalama anestezi süresi 3,7 (±0.65 SS) saat olarak tespit edildi. Hastaların 135’i (67,5%) erkek 65’i (32,5%) kadındı ve 123 (61.5%) hastada canlıdan canlıya transplantasyon yapılırken 77 (38.5%) hastaya kadavradan yapılmıştır. Bu çalışmada hipertansiyon (27.5%, n: 55), diabetes mellitus ( 22.5%, n: 45), sebebi bilinmeyen (18.5%, n: 37), kronik glomerulonefrit (13.5%, n: 27), amiloidoz (8.5%, n: 17) and diğerleri (9.5%, n: 19) son dönem böbrek yetmezliği nedenleriydi. Akut rejeksiyon 21 (10.5%) hastada görülürken gecikmiş greft fonksiyonu 27 (13.5%) hastada görüldü. 24 (12%) hastada transplantasyon sonrası takiplerinde mortalite tespit edildi. TARTIŞMA ve SONUÇ: Renal transplantasyon böbrek yetmezliği tedavisi için iyi bir seçimdir ve anestezi yönetimi greft fonksiyonu için çok önemlidir. Bizim çalışmamızdaki anestezi yönetimi ve sonuçlarımız literatürle benzerd
Examining Student Preparation for Certification Examination: An Exploratory Case Study

Chapter One: Introduction and Background 1 1.0 Introduction 1 1.1 Background 5 1.1.1 Nursing 5 1.1.2 Disability Studies 7 1.1.3 Accounting 9 1.2 Statement of the Problem 11 1.3 Research Orientation & Brief Overview/Description of Approaches 11 Chapter Two: Review of Literature 13 2.1 Nursing Education 13 2.2 Education and Curriculum Design in Post-Secondary 18 Chapter Three: Design 21 3.0 Introduction 21 3.1 Scoping Review 21 3.1.1 Identifying the Research Question 21 3.1.2 Identifying the Relevant Studies 22 3.1.3 Study Selection 25 3.1. 4 Charting the Data 25
Does Late-Onset Huntington Disease Represent a Distinct Symptomatic Picture? Evidence for a Selective Deficit in Executive Function and Emotion Recognition, in the Absence of Behavioral and Psychiatric Disorders

: Huntington Disease (HD) is an autosomal-dominant, neurodegenerative disorder, including motor, cognitive, emotional and behavioral symptoms. Motor symptoms used to set the clinical onset, typically emerge in the middle age. Here, we describe the case of a patient, who received a genetic diagnosis at 75 years and developed motor symptoms at 80. The Patient shows severe motor symptoms in the absence of personality changes or psychiatric disorders typically observed in HD. For what attain neuropsychological profile, it results unaltered apart from a specific deficit in emotion recognition and general slowness on executive functioning tasks, reflecting a specific trade-off between accuracy and rate of performances, that is a selective impairment in fine-tuning of resources. Both of these deficits in the Patient could be ascribable to the frontostriatal atrophy, evidenced by Computed Tomography. While deficit in emotion recognition is a well-known symptom in HD, a deficit in fine-tuning of resources regards a specific aspect of executive function. The ability of fine-tuning resources is the latest step in the development of executive functions, and it could be also the first level to be impaired in HD. We proposed that deficit in fine-tuning of resources could be the core of the neuropsychological deficit in late-onset HD.
Enhanced Mid-Latitude Meridional Heat Imbalance Induced by the Ocean

The heat imbalance is the fundamental driver for the atmospheric circulation. Therefore, it is crucially important to understand how it responds to global warming. In this study, the role of the ocean in reshaping the atmospheric meridional heat imbalance is explored based on observations and climate simulations. We found that ocean tends to strengthen the meridional heat imbalance over the mid-latitudes. This is primarily because of the uneven ocean heat uptake between the subtropical and subpolar oceans. Under global warming, the subtropical ocean absorbs relatively less heat as the water there is well stratified. In contrast, the subpolar ocean is the primary region where the ocean heat uptake takes place, because the subpolar ocean is dominated by upwelling, strong mixing, and overturning circulation. We propose that the enhanced meridional heat imbalance may potentially contribute to strengthening the water cycle, westerlies, jet stream, and mid-latitude storms.
Low‐profile SIW cavity antenna with enhanced bandwidth and controllable radiation null

A low‐profile substrate‐integrated‐waveguide (SIW) cavity antenna with enhanced bandwidth and a controllable radiation null is proposed. Serving as radiating elements, two slots are etched on a square SIW cavity. Four cavity modes including a fundamental mode (FM), a half mode (HM), and two quarter modes (QMs) are excited by a capacitively coupled feeding disc. Their frequencies can be controlled by adjusting positions of the slots and disc. Three radiating modes (ie, a HM and two QMs) are utilized to realize an antenna passband with enhanced bandwidth while a nonradiating mode (ie, the FM) is utilized to achieve a radiation null resulting in the sharp upper sideband and high stopband suppression. Experimental results show that the fabricated antenna with the profile of less than 0. 04λ0 obtains the bandwidth of 440 MHz, gain of 5.24 dBi, and efficiency of 84%. However, the gain sharply drops to −22.07 dBi and the efficiency achieves a very low value of 0.15% at the radiation null. Due to covering the frequency band of 3.40‐3.60 GHz, the proposed design has potential applications for fifth‐generation (5G) wireless systems.
Understanding access and use of municipal parks and recreation through an intersectionality perspective

Abstract We applied the multiple hierarchy stratification perspective to examine how access and use of municipal parks and recreation vary based upon the intersections of gender, race/ethnicity, age, income, place of residence, and education. We hierarchically stratified demographic combinations and calculated probabilities for having a park within walking distance, using parks, and participating in recreation programs. Findings demonstrated that as membership in multiple marginalized groups increases, individuals are generally less likely to visit parks and perceive they have a park within walking distance from home. However, program participation did not show a similar trend. Research has repeatedly identified various benefits of parks and recreation, yet disparities by social stratification may be impeding access to those benefits, particularly among those belonging to multiple marginalized groups. To reduce such disparities, park and recreation agencies should focus on increasing engagement among the most underserved groups—individuals with multiple disadvantaged statuses.
Q-Fever, an undermined zoonotic threat

With upto 75% of all human disease being zoonotic in origin, proper study of the diseases is necessary to prevent any outbreak or human loss. More studies are required for developing countries like Nepal where there are no appropriate provisions for situations after breakouts. One such little known sporadic zoonosis is Q-fever. Q-fever (Coxiellosis) is caused by Gram-negative bacterium Coxiella burnetii that infect cattle and other ruminants with serious concerns for developing reproductive disorders and flu-like symptoms in human. There have been reports of undifferentiated febrile illness of Rickettsial cause in human and seroprevalence of Coxiella antibodies in goats of Chitwan and dairy cattle of Rupandehi for the first time. Low infectious dose and high resistivity to environment makes the disease more potent. Q-fever continues to be unexplored in Nepal despite its identification in neighboring countries like India. Thus, this paper after reviewing related articles from various journals, proceedings and magazines from online sources like Google Scholar, Mendeley, NCBI and PubMed is aimed to evaluate current status of disease, its epidemiology, zoonotic potential and preventive measures that can be adopted to minimize the threat of the disease as much as possible.
Modelling Form-Meaning Systematicity with Linguistic and Visual Features

Several studies in linguistics and natural language processing (NLP) pointed out systematic correspondences between word form and meaning in language. A prominent example of such systematicity is iconicity, which occurs when the form of a word is motivated by some perceptual (e.g. visual) aspect of its referent. However, the existing data-driven approaches to form-meaning systematicity modelled word meanings relying on information extracted from textual data alone. In this paper, we investigate to what extent our visual experience explains some of the form-meaning systematicity found in language. We construct word meaning representations from linguistic as well as visual data and analyze the structure and significance of form-meaning systematicity found in English using these models. Our findings corroborate the existence of form-meaning systematicity and show that this systematicity is concentrated in localized clusters. Furthermore, applying a multimodal approach allows us to identify new patterns of systematicity that have not been previously identified with the text-based models.
Complementary methods of study for Zr1-xCexO2 compounds for applications in medical prosthesis

Zirconia (ZrO2)-based ceramics are preferred due to their advanced mechanical properties such as high-fracture toughness and bulk modulus, corrosion resistance, high dielectric constant, chemical inertness, low chemical conductivity and biocompatibility. The medical prosthesis components made from ZrO2 oxides present a very good biocompatibility as well as especially mechanical properties. In order to ensure implant safety of these prostheses, wide ranges of examinations based on nondestructive testing are imperative for these medical implants. In this study, we aim to emphasize the improvement of Zr-based ceramics properties as a function of addition of Ce ions in the structure of the original ceramics. The substitution of the Zr with Ce in the Zr1-xCexO2 compounds, where x = 0.0–0.17, leads to a change of the phase composition, a gradual transition from the monoclinic to tetragonal structure, at room temperature. The structural investigations proposed in this paper are based on X-ray and neutron diffraction in order to establish a first indication of the variation of the phase composition and the structural parameters, as well as micro-hardness measurements and nondestructive evaluations in order to establish a correlation between the structural parameters and mechanical properties of the samples. These ranges of tests are imperative in order to ensure the safety and reliability of these composite materials, which are widely used as hip-implants or dental implants/coatings. In combination of Resonant Ultrasound Spectroscopy, which makes use of the resonance frequencies corresponding to the normal vibrational modes of a solid in order to evaluate the elastic constants of the materials, we emphasize a unique approach on evaluating the physical properties of these ceramics, which could help in advancing the understanding of properties and applications in medical fields.
Anthracycline versus Non-Anthracycline Induction Regimens in Patients with De Novo Acute Myeloid Leukemia

Background & Objectives: Acute myeloid leukemia (AML) is the most prevalent form of acute leukemias in adults; unfortunately it carries very poor prognosis. Over the past decade marvelous advances were achieved in understanding pathophysiology of AML and this was reflected in management of AML patients. Nevertheless the standard anthracycline based induction regimens remained the cornerstone for treatment of AML; however their effectiveness is limited by their well known cardiotoxicity. To our knowledge this is the first study that investigated anthracycline versus non-anthracycline induction regimens in patients with AML. Methods: 90AML patients were enrolled in the study; they were retrospectively recruited from AML patients who were admitted at South Egypt Cancer Institute (SECI) from 2000-2010. Demographic, clinical, hematologic and data concerning treatment and therapeutic response were collected from hospital records of patients. Results: Analysis of the collected data showed lower median age of the study participants compared to other studies, FAB M2, M3, M4, followed by M1 were the commonest FAB subtypes among the study patients. Survival analysis showed longer overall survival (OS) and progression free survival (PFS) in those treated with anthracycline induction regimens compared with the non-anthracycline treated group. Also, higher incidence of relapse was observed in the non-anthracycline group. Conclusion: Anthracycline based induction regimens are still more effective than non-anthracycline regimens for treatment of AML, however the search for safer drugs than anthracyclines is still mandatory.