Miracle-dz/UniFAR-FTUs huggingface dataset:
Electric activity of lumbar muscles in sport climbers

Background: The synergy of all muscle groups seems to play crucial role in professional sport climbing. Climbing activity demands good balance and coordination between various parts of musculature. Unfortunately, this issue is an under-reviewed aspect in the literature. Aim: The aim of this study was to compare the endurance-fatigue characteristics in rectus abdominals (RA) and erector spinae (ES) muscles during the isometric exercises performed by professional and amateur sport climbers. Material and methods: We examined 50 healthy sport climbers (38 men, 12 women) aged 23 ± 3 years. Participants were divided into two groups: 25 professional and 25 amateur sport climbers. The International Climbing and Mountaineering Federation UIAA scale was used for classification: professional climbers > X-, amateurs < VII. The myoelectric activity of the RA and ES muscles was recorded simultaneously during isometric activity in a basic plank position. Results: Significant differences in ES and RA muscles activity, between professional climbers and amateurs, were observed during trunk muscle strength tests in a basic plank position. EMG median frequency was reduced from beginning to end of exercise (amateur climbers: RA - 23.40%, ES - 26.81%; professional climbers: RA - 19.69%, ES - 15.78%; p < 0.001). Conclusions: Difference in muscle activity between professional and amateur sport climbers suggests that rectus abdominals and erector spinae muscles plays an important role in climbing.
Perceptual and Reproductive Learning for Line Drawing Strokes Using Active Wheel-Based Finger Tactile Interface

—The goal of this paper is to establish an intensive training procedure for improving subjects’ tactile-motor performance for an active wheel-based finger tactile interface. The methodology for achieving the goal is to propose a training procedure, and to show perceptual learning characteristic improvements as a result of the intensive training. Concretely, subjects repeated a tactile-motor learning trial composed of a slippage perception and a stroke reproduction. That is, a learning trial is constituted of four steps: (1) a target hand-stroke, i.e., a uniform motion, is presented as a slippage by the active-wheel-based finger-tactile interface, (2) a subject reproduces the slippage as a hand-stroke, (3) accepting the slippage corresponding to the subject-reproduced stroke, the subject improves their slippage sensitivity, (3) accepting the initial slippage corresponding to the target hand-stroke, the subject furthermore improves their slippage sensitivity. The training had been conducted for eight days, three sessions a day, 16 learning trial a session. As a result of a psychophysical experiment with eight subjects involving an intensive eight-day training, the subjects significantly improved their slippage-perception and stroke-reproduction ability. The 1st day training doubled the perceptual sensitivities: the sensitivities were defined by a ratio of an estimated slope to the standard error with respect to the reproduced stroke speed, by another ratio with respect to the time-duration, and by the standard deviations with respect to the reproduced stroke angular error. Furthermore, the intensive eight-day training made the speed-perceptual sensitivity two-times better than that after the 1st day training. Thus, a learning effect was significantly observed, and, consequently, the effectiveness of the proposed training procedure was confirmed.
A sentiment analysis approach to increase authorship identiﬁcation

: Writing style is considered the manner in which an author expresses his thoughts, inﬂuenced by language characteristics, period, school, or nation. Often, this writing style can identify the author. One of the most famous examples comes from 1914 in Portuguese literature. With Fernando Pessoa and his heteronyms Alberto Caeiro, ´Alvaro de Campos and Ricardo Reis, who had completely different writing styles, led people to believe that they were different individuals. Currently, the discussion of authorship identiﬁcation is more relevant because of the considerable amount of widespread fake news in social media, in which it is hard to identify who authored a text and even a simple quote can impact the public image of an author, especially if these texts or quotes are from politicians. This paper presents a process to analyse the emotion contained in social media messages such as Facebook to identify the author’s emotional proﬁle and use it to improve the ability to predict the author of the message. Using preprocessing techniques, lexicon-based approaches and machine learning, we achieved an authorship identiﬁcation improvement of approximately 5% in the whole dataset and more than 50% in speciﬁc authors when considering the emotional proﬁle on the writing style, thus increasing the ability to identify the author of a text by considering only the author’s emotional proﬁle, previously detected from prior texts.
Chromatin Remodeling of the TNF Locus Gene Expression via Interference with Type 1 Subtype E Selectively Inhibits TNF Transactivator of Transcription from HIV

The transactivator of transcription (Tat) protein is essential for efﬁcient HIV type 1 (HIV-1) replication and is involved in the transcriptional regulation of the host immune response gene, TNF. In this study, we demonstrate that Tat proteins from representative HIV-1 subtype E isolates, but not from subtypes B or C, selectively inhibit TNF gene transcription and protein production in CD4 (cid:1) Jurkat T cells. Strikingly, we show that this repression is due to a tryptophan at residue 32 of Tat E and is secondary to interference with recruitment of the histone acetyltransferase P/CAF to the TNF promoter and with chromatin remodeling of the TNF locus. This study presents a novel mechanism by which HIV-1 manipulates a host immune response gene that is important in its own replication. Moreover, these results demonstrate a new mechanism by which the TNF gene is regulated via chromatin remodeling secondary to viral infection. The Journal of Immunology, 2006, 176: 4182–4190.
Curvature of the Induced Riemannian Metric on the Tangent Bundle of a Riemannian Manifold.

If M is an ra-dimensional differentiable manifold (n £ N) with the Riemannian metric g, then the tangent b ndle TM of M admits a canonical Riemannian metric Tg (see [1], [2]). In other words, a metric connection v on M induces, in a canonical way, a metric connection v on TM. Further, A. J. Ledger and K. Yano ([3], [4]) found a different construction joining to any linear connection v on M a linear connection v on TM. The basic result of [4] says that the space (M, v) is locally Symmetrie if and only if the space (T M, v) is locally Symmetrie, In the present paper we compute the curvature tensor of the Riemannian space (TM, Tg) corresponding to (If, g). We deduce, in contrast to the Yano-Ledger's theory, the following result: The space (TM, Tg) is never locally Symmetrie unless (M, g) is locally euclidean.
Suppression of Information Diffusion in Social Network Using Centrality based on Dynamic Process

—Individual activities propagate on social networks and had a large impact on our society. For example, incitement acts such as hoaxes, widely propagated through social media, gave unnecessary confusion and uneasiness to many people. The purpose of this study is to propose an edge centrality index in a network considering the propagation of activities through analysis. Our previous studies have proposed an evaluation method that quantiﬁes the edge importance based on an activity propagation model. The model represents the propagation by an equalization process of the variable amount given to each vertex. This paper experimentally shows that the information diffusion can be suppressed by using the edge importance measure. The experiment veriﬁes that the range of information diffusion becomes smaller than that before deleting some edges from the network based on the importance measure.
Design Science in Engineering Education Research

My research interest concerns the effects of brief, integrated information literacy education on undergraduate students’ research behavior. My teaching experience consists of over 30 years of information literacy education within higher education. Over the years, the content and educational methods have changed greatly. We have moved from library user education to teaching students to understand their information need as part of their research problem. Digitalization has changed teaching methods from plain classroom teaching to using a wide variety of different tools and learning platforms.
Expression Profiles of the Trehalose-6-Phosphate Synthase Gene Associated With Thermal Stress in Ostrinia furnacalis (Lepidoptera: Crambidae)

Trehalose is the major blood sugar in insects. Physiological significance of this compound has been extensively reported. Trehalose-6-phosphate synthase (TPS) is an important enzyme in the trehalose biosynthesis pathway. Full-length cDNAs of TPS ( Of tps ) and its alternative splicing isoform ( Of tps _isoformI) were cloned from the Asian corn borer (ACB), Ostrinia furnacalis (Guenée; Lepidoptera: Crambidae) larvae. The Of tps and Of tps _isoformI transcripts were 2913 and 1689 bp long, contained 2529 and 1293 bp open reading frames encoding proteins of 842 and 430 amino acids with a molecular mass of 94.4 and 48.6 kDa, respectively. Transcriptional profiling and response to thermal stress of Of tps gene were determined by quantitative real-time PCR showing that the Of tps was predominantly expressed in the larval fat body, significantly enhanced during molting and transformation; and thermal stress also induced Of tps expression. Gene structure analysis is indicating that one TPS domain and one trehalose-6-phosphate phosphatase (TPP) domain were located at the N- and C-termini of Of TPS, respectively, while only the TPS domain was detected in Of TPS_isoformI. Three-dimensional modeling and heterologous expression were developed to predict the putative functions of Of TPS and Of TPS_isoformI. We infer that the expression of Of tps gene is thermally induced and might be crucial for larvae survival.
動的計画法による木質建材生産を目的とした伐採計画の最適化 Optimization of Harvest Scheduling to Produce Wood-based Materials with Dynamic Programming

: Kyushu Electric Power Co., Inc. is carrying on a project that handles from silviculture and harvesting to house building in order to make more profit in this severe situation for foresters. In this paper, as a basic research suggesting example. The method is generally similar to a forest stand optimization model called DP-KYSS within the dynamic programming framework. We improved it that we could consider more detail about the purpose of this research. In the result, the profit (as SEV: soil expectation value) increased about 1.2 times compared with the present plan. However we have some problems, for example, the impracticality in the plan and the algorithmic instability.
RELIABILITY OF THE LAPAROSCOPIC IDENTIFICATION OF THE LEVEL OF TRANSITIONAL ZONE IN HIRSCHSPRUNG`S DISEASE

It All ABSTRACT Background/Aim: It is crucial to exactly identify the level of transition to the normal ganglionic colon in instances of Hirschprung's disease (HD). The correlation between the laparoscopic leveling of the transitional zone (TZ) and frozen section histopathologically based level of aganglionosis has not been well studied. The aim of this study is to assess whether the laparoscopic leveling of TZ could be a reliable method for the diagnosis of the actual level ofaganglionosis of the HD. Patients and Methods: The study included 150 patients’ diagnosedas HD by rectal biopsy. All patients were subject to laparoscopy for identification of TZ. Three laparoscopic seromuscularbiopsies was taken for intra-operative frozen section [IOFS] from thelaparoscopically identified TZ, 2-cm distal and 10-cm proximal to TZ. In cases of non-identification of any TZ, laparoscopic seromuscular biopsies were taken from therectosigmoid, sigmoid, descending colon, splenic flexure and the transverse colon for IOFS. Then, laparoscopic assisted endo-rectal pull through was completed according to the results of IOFS. The results of IOFS were compared with the results of permanent paraffin section Results: The study included 98 males and 52 females with HD. Their mean age was 2.4±12 years (age range = 5 months to 6 years). All operations were completed laparoscopically without conversion. The mean operative time was 54.4±12 minutes (range =45 to 70 minutes). Laparoscopic identification of the TZ coincided with the suspected TZ in the images of preoperative barium enema in 125 patients. While in 25 patients without a detectable TZ in the preoperative barium enema, TZ was identified laparoscopically. Laparoscopic identification of the level of the TZ zone coincided with thehistopathological results of IOFS [IOFS] and permanent paraffin section in all patients. No intraoperative complications were reported. Conclusion: Laparoscopic identification of TZ in patients with HD is a feasible and a safe procedure. It is a reliable method for determining the actual level of aganglionosis in HD.
Finding Functionality: Rasch Analysis of the Functionality Appreciation Scale in community-dwelling adults including adults with spinal cord injury and neuropathic pain in the US

The Functionality Appreciation Scale (FAS) measures an appreciation of the individual for the functions their body can perform, regardless of physical limitations of the individual. To facilitate the use of this tool by researchers and clinicians, it is necessary to understand what normal scoring looks like in healthy adults, as well as validate the scoring of this scale. We analyzed the FAS using Rasch Measurement Theory. FAS responses, demographic data, and clinical questionnaires were collected by the Brain Body Mind Lab (University of Minnesota) from 567 community-dwelling adults recruited at the Minnesota State Fair, including 14 adults with spinal cord injury. We evaluated item and person fit, targeting, unidimensionality, person separation reliability (PSR), local item dependence (LID), and differential item functioning (DIF) for demographic and clinical characteristics. We found a significant ceiling effect (26.98%) and a positive person mean location of 3.28 +/- 2.10 logits, indicating the FAS is too easy for the community-dwelling adults in the US. PSR was 0.79, indicating a capacity to differentiate groups of people according to their ability level of functional appreciation. We also compared the person mean location of adults who did or did not participate in body awareness training. Adults who practiced body awareness training had a higher person mean location (4.28, Interquartile Range [IQR] = 3.96 logits) than those who did not (2.73, IQR = 3.34), indicating a higher functionality appreciation. Overall, FAS demonstrated good item and person fit, but the current version of FAS will require more difficult items to be added to improve the targeting of the scale for use in a general population.
Efficacy of Mirror Therapy In Improving Motor Recovery And Functional Ability of The Hemiparetic Lower Limb after Stroke

Lower extremity motor function after stroke is often impaired, causing restriction in functional mobility. This study investi- gated the efficacy of mirror therapy on lower extremity motor recovery and functional ability after stroke.In this pre-test/post-test randomized controlled trial, a total of twenty (22) hemiparetic stroke patients were recruited, however, 20 completed the program. Mini mental state examination (MMSE) and Brunstrom stage of motor recovery were used as screening tools. Fugl-Meyer Assessment scale (FMA), Brunnel balance assessment scale (BBA) and Functional Ambulation Category (FAC), were used as primary outcome measures. Wilcoxon signed rank test was used to compared the pre- and post-treatment outcomes within each group. Mannwhitney U test was used to compare treatment responses between control group and experimental group.The results showed that, for the FMA, there was no statistically significant difference at baseline between the experimental and control groups ( P >0.05), after the intervention, there was statistically significant difference between the groups ( P <0.05) . For BBA), there was no statistically significant differ- ence at baseline between the groups ( P >0.05), for the post intervention, it was found that there was no statistically significant difference between the groups ( P >0.05) . For FAC, there was no statistically significant difference at baseline between the groups ( P >0.05), for post-intervention, there was statistically significant difference between the groups ( P <0.05). Administration of three(3) weeks of mirror therapy during the acute and sub-acute stages of stroke resulted in significant recovery in motor function. However, no differ- ence on a BBA was recorded. in management of lower limb of sub-acute stroke patients.This research is aimed at finding the effect of Mirror therapy on functional recovery of lower limb following stroke.
Cancer associated eIF1A mutants impair Rps3 and Rps10 binding and enhance scanning of cell cycle genes

Protein synthesis is linked to cell proliferation and its deregulation contributes to cancer. eIF1A plays a key role in scanning and AUG selection and differentially affects translation of distinct mRNAs. Its unstructured N-terminal-tail (NTT) is frequently mutated in several malignancies. Here we report that eIF1A is essential for cell proliferation and cell-cycle progression. Ribosome-profiling of eIF1A knockdown cells revealed a substantial enrichment of cell-cycle mRNAs among the downregulated genes, which are predominantly characterized by lengthy 5’UTR. Conversely, eIF1A depletion caused a broad stimulation of 5’UTRs initiation at near-cognate AUG, unveiling a prominent role of eIF1A in suppressing 5’UTR translation. In addition, the AUG-context dependent auto-regulation of eIF1 is disrupted by eIF1A depletion suggesting for their cooperation in AUG-context discrimination and scanning. Importantly, cancer-associated eIF1A-NTT mutants augment eIF1A positive effect on long 5’UTR while hardly affecting AUG selection. Mechanistically, these mutations diminish eIF1A interaction with Rps3 and Rps10 implicated in scanning-arrest. Our findings suggest that reduced binding of eIF1A NTT mutants to the ribosome retains its open state and facilitate scanning of long 5’UTR-containing cell cycle genes. suppression of inappropriate initiation. We further demonstrate that the cancer-associated NTT mutants elevate the scanning promoting activity eIF1A on long 5’UTR but have little effect on AUG selection. At the molecular level, these mutations diminish eIF1A interaction with A-site ribosomal proteins Rps3 and Rps10 which are involved in scanning arrest. Our findings provide a mechanistic basis for promotion of cell proliferation by eIF1A-NTT mutants which involves scanning enhancement of long 5’UTR-containing cell cycle genes.
Microvascular Obstructions Measured by Cardiac Magnetic Resonance, and their Role as a Predictor of Outcomes in Acute Myocardial Infarction

Microvascular Obstructions Measured by Cardiac Magnetic Resonance, and their Role as a Predictor of Outcomes in Acute Myocardial Infarction. J Cardiothorac Surg Ther Abstract Background: Acute myocardial infarction (AMI) is one the main causes of morbidity and mortality in Chile and the world. Cardiac magnetic resonance (CMR) is gaining evidence as a tool to determine prognosis in patients who have suffered an AMI. Microvascular obstructions (MVO) represent non-irrigated areas of the myocardium after reperfusion, and it is determined by CMR. After reestablishment of cardiac blood flow, MVOs could be used as a new marker to determine the heart injury due to AMI and reperfusion damage. Method and materials: A retrospective analysis of a clinical trial was performed (ISRCTN registry: 56034553). 67 patients suffering ST-segment elevation AMI (STEMI), undergoing a percutaneous coronary angioplasty were studied with a CMR from 7 to 15 days after the intervention. MVOs, infarct size, left ventricular ejection fraction, and left ventricular end-systolic volume indexed to body surface area were determined by three radiologists, blinded to clinical information. Results: The development of MVOs was associated with a bigger infarction size (p < 0.05), a lower ejection fraction (p < 0.05) and a bigger end systolic volume (p < 0.05) in patients with AMI. Conclusion: MVOs can be accurate predictors for morphological and functional complications posterior to AMI.
A note on wind velocity and pressure spectra inside compact 1 spherical open celled porous microphone windscreens

11 Simultaneous measurements of wind velocity and pressure fluctuations are conducted in 12 a wind tunnel to investigate the wind noise source inside compact spherical open celled 13 microphone windscreens. The existing outdoor wind noise models are found to be 14 inadequate to predict the wind noise inside a wind tunnel. This paper proposes a model 15 to predict the interior stagnation pressure, which agrees with the wind noise measured 16 inside the windscreen within a bandwidth, where the exterior turbulence-turbulence 17 interaction pressure overestimates the wind noise level. The shortcomings of the 18 proposed model and other potential sources for wind noise inside porous windscreens 19 are discussed.
Generation and characterization of anti-AAV8 and anti-AAV9 monoclonal antibodies

Adeno-associated viruses (AAVs) are promising viral vectors for therapeutic gene delivery, and the approval of an AAV1 vector for the treatment of lipoprotein lipase deficiency has heralded a new and exciting era for this system. However, preclinical and clinical studies show that neutralization from pre-existing antibodies is detrimental for medical application and this hurdle must be overcome before full clinical realization can be achieved. Thus the binding sites for capsid antibodies must be identified and eliminated through capsid engineering. Towards this goal and to recapitulate patient polyclonal responses, a panel of eight new mouse monoclonal antibodies (MAbs) has been generated against AAV8 and AAV9 capsids, two vectors in development for therapeutic application. Native (capsid) dot blot assays confirmed the specificity of these antibodies for their parental serotypes, with the exception of one MAb, HL2372, selected to cross-react against both capsids. Furthermore, in vitro assays showed that these MAbs are capable of neutralizing virus infection. These MAbs will be utilized for structural mapping of antigenic footprints on their respective capsids to inform development of the next generation of rAAV vectors capable of evading antibody neutralization while retaining parental tropism.
Notes on Semi-Supervised Expectation Maximization

This work considers the Expectation Maximization (EM) algorithm in the semi-supervised setting. First, the general form for semi-supervised version of maximum likelihood is derived from the Latent Variable Model (LVM). Since the involved integrals are usually intractable, a surrogate objective function based on the Evidence Lower Bound (ELBO) is introduced. Next, we derive the equations of the semi-supervised EM. Finally, the concrete equations for a ﬁtting a Gaussian Mixture Model (GMM) using labeled and unlabeled data are deduced