Miracle-dz/UniFAR-FTUs huggingface dataset:
PSMA-Targeted Mesoporous Silica Nanoparticles for Selective Intracellular Delivery of Docetaxel in Prostate Cancer Cells

Although docetaxel is currently broadly used in prostate cancer treatment, poor water solubility and systemic toxicity limit the dose and duration of therapy. In this context, although different nanoplatforms have been proposed to overcome these issues, selective therapy needs developing methodologies to target malignant cells and minimizing the impact on healthy tissue. We here present a novel drug delivery system obtained by covalent conjugation of docetaxel and an anti-prostate specific membrane antigen (PSMA) molecule (anti-FOLH1 monoclonal antibody, clone C803N) over mesoporous silica nanoparticles. This conjugate remains stable in physiological medium and shows high selectivity for LNCaP, a specific cell line that overexpresses PSMA. As a consequence, cell internalization is increased by 25%. Furthermore, cytotoxic activity of the targeted system increases by 2-fold with regard to nontargeted nanoparticles and by 2 orders with regard to the naked drug. Conversely, no targeting effect is observed ove.
Is there a correlation between functional results and radiographic findings in patients with distal radius fracture A0 type A3 treated with volar locking plate or external fixator?

Purpose: The aim of this study was to test the hypothesis that precise restoration of distal radius fractures is correlated to better patient-reported outcome. Methods: The correlation between radiographic results and functional outcome was explored in 156 patients with extra-articular distal radius fractures included in a multicenter, randomized controlled trial comparing 2 surgical interventions, Volar Locking Plate or External Fixator. The primary functional outcome was the Patient Rated Wrist and Hand Evaluation score (PRWHE). Radiographically we assessed volar tilt, radial inclination, radial height, ulnar variance, and the presence of ulnar styloid fracture. The Pearson correlation analysis was used to estimate correlations between parameters. Results: At 1-year follow-up the mean difference in radiographic findings compared with the uninjured side (min, max) was: reduced volar tilt 5.3° (−15°, 25°), reduced radial inclination 2.3° (−6°, 12°), radial height 1.3 mm (−4 mm, 7 mm), and ulnar variance −0.5 mm (−6 mm, 3 mm). Overall, we found no correlation between radiographic parameters and the PRWHE at 1-year follow-up within the whole group, regardless of which treatment was chosen. At the time of injury 53% (N = 80) had sustained an additional ulnar styloid fracture. After 1 year this fracture was still radiographically present in 31% (N = 43) of the patients. No correlation between PRWHE score and the presence of an ulnar styloid fracture at 1-year follow-up was found. Conclusions: We found no correlation between functional outcome (PRWHE) and radiographic findings after 1 year in patients operated on with a Volar Locking Plate or External Fixator. Patient-specific factors were more important than radiographic measurements in this study group. Level of evidence: Therapeutic Level 2 Trial registration: Norway: National Committee for Medical and Health Research Ethics 213/555 ClinicalTrials.gov ID: NCT01904084 Randomization of first patient: 02.09. 2013
LANGUAGE STYLE IN FASHION ADVERTISEMENTS OF ONLINE VOGUE MAGAZINE

In advertising, one of the purposes of communication is to offer a particular product. Advertisements display the advantages, features, and values of the products. This paper aimed to analyse the language styles used in online Vogue Magazine fashion advertisements. The data were collected by selecting ten advertisements collected from Vogue Magazine’s compilation entitled “The Fall 2020 Trends Vogue Edition Editors are Shopping This Season” published on 18 September 2020. The researchers employed mixed methods to analyse the language styles used in the fashion advertisements based on nine types of language styles proposed by Wells, Burnett, and Moriarty (1995). The results showed that there were three language styles found from ten online fashion advertisements in Vogue Magazine advertisements, namely the hard sell style (three times), soft sell style (three times), and mixed style or the combination of the hard sell and soft sell styles (four times). Each advertisement style has its specific features and functions in fashion promotion.
Acoustic confinement of Escherichia coli: The impact on biofilm formation

Brownian or self-propelled particles in aqueous suspensions can be trapped by acoustic fields generated by piezoelectric transducers usually at frequencies in the Megahertz. The obtained confinement allows the study of rich collective behaviours like clustering or spreading dynamics in microgravity-like conditions. The acoustic field induces the levitation of selfpropelled particles and provides secondary lateral forces to capture them at nodal planes. Here, we give a step forward in the field of confined active matter, reporting levitation experiments of bacterial suspensions of Escherichia coli. Clustering of living bacteria is monitored as a function of time, where different behaviours are clearly distinguished. Upon the removal of the acoustic signal, bacteria rapidly spread, impelled by their own swimming. Trapping of diverse bacteria phenotypes result in irreversible bacteria entanglements and in the formation of free-floating biofilms. Confinement acoustique de Escherichia coli: L’impact dans la formation de biofilms. Salomé Gutiérrez Ramos
The Place of Free Fatty Acids and Water in Biodiesel Production Process from Waste Oils

Biodiesel is a fuel that used in diesel engines produced from various renewable resources (plant, animal fats, waste oils, algae, etc.) and has high potential to be an alternative to standard diesel fuel. Using waste oils which cause significant damages when they are poured to environment should be preferred rather than using edible oils as a raw material in biodiesel production. This situation has a great importance for lowering the cost of biodiesel production, protecting of edible oil source and minimizing damages of waste oils on environment. In this study, importance of used vegetable and animal oils which is specified to be waste oil was evaluated in terms of environment and biodiesel production costs. In addition, it was investigated that, the effect of free fatty acids of waste oils (FFA) and water to the biodiesel production process in the literature.
The Role of External Support on the Implementation of Resource Efficiency Actions: Evidence from European Manufacturing Firms

This paper contributes to analyze the relationship between firms’ recourse to different types of external support and adoption of environmental sustainability practices. To this aim, we consider both direct financial support and indirect support, in the form of advice and consulting services, upon which the firm relies on in its efforts to be more resource efficient. The empirical analysis uses data on 6595 manufacturing firms from 35 European countries, taken from the third and fourth waves of the Flash Eurobarometer survey “Small and Medium Enterprises, Resource Efficiency and Green Markets”. Our empirical findings suggest that firms using external financing and external advice are more likely to implement greening investments and practices. Moreover, we provide strong empirical evidence that external support significantly contributes to increase the benefits from the adoption of resource efficiency actions in terms of production cost reduction. This study further contributes to the existing literature by highlighting the heterogenous effects of direct and indirect external support on the environmental sustainability actions of both SMEs and large firms.
The Microorganism Acidithiobacillus ferrooxidans can use Electrical Current as a Direct and Sole Energy Source

Objective: It is well known that there are two main groups of living organisms in terms of their energy source: chemotrophs and phototrophs. Recently it has been shown that some living organisms, and in particular, microorganisms, could use electrical current as both a sole energy source and as an electron donor. This, third group of organisms, was named electro trophs.The main goal of this work is to prove that the microorganism Acidithiobacillus ferrooxidans can live in electro trophic mode. Methods: A novel electro bioreactor was designed and built in order to supply microorganisms with electrical current (electrons) as an electron donor. Results and Conclusion: The experimental results reported here show for the first time that the aerobic microorganism Acidothiobacillus ferrooxidans, can live in an electro trophic mode.
Comparative Degradation of C. I. Acid Green 25 and C. I. Basic Blue 9 by Electrochemical, Photoelectrochemical and Photocatalytic Oxidation Methods

The electrochemical, photoelectrochemical, and photocatalytic degradation of C. I. Acid Green 25 (AG) and C. I. Basic Blue 9 (Methylene Blue, MB) was investigated. For the electrochemical and photoelectrochemical oxidation, a titanium electrode coated with a mixture of TiO 2 /RuO 2 was employed. In the photocatalytic degradation, Pt/P25 catalysts containing different amounts of platinum were used. The highest effectiveness of C. I. Acid Green 25 conversion (up to 90% based on TOC and up to 96% based on COD) was achieved using the photocatalytic method with the application of Pt/P25 catalyst (ca. 0.50 wt.% of Pt). The photoassisted electrolysis of C. I. Basic Blue 9 gave a comparable conversion (based on TOC  86%) to that obtained with Pt/P25 photocatalytic treatment (based on TOC  89%) in which a very small increase in the decolourisation rate constant over P25 alone was noted.
Sustainable Biological Ammonia Production towards a Carbon-Free Society

A sustainable society was proposed more than 50 years ago. However, it is yet to be realised. For example, the production of ammonia, an important chemical widely used in the agriculture, steel, chemical, textile, and pharmaceutical industries, still depends on fossil fuels. Recently, biological approaches to achieve sustainable ammonia production have been gaining attention. Moreover, unlike chemical methods, biological approaches have a lesser environmental impact because ammonia can be produced under mild conditions of normal temperature and pressure. Therefore, in previous studies, nitrogen fixation by nitrogenase, including enzymatic ammonia production using food waste, has been attempted. Additionally, the production of crops using nitrogen-fixing bacteria has been implemented in the industry as one of the most promising approaches to achieving a sustainable ammonia economy. Thus, in this review, we described previous studies on biological ammonia production and showed the prospects for realising a sustainable society.
Experimental verification of group non-membership in optical circuits

The class quantum Merlin–Arthur (QMA), as the quantum analog of nondeterministic polynomial time, contains the decision problems whose YES instance can be verified efficiently with a quantum computer. The problem of deciding the group non-membership (GNM) of a group element is conjectured to be a member of QMA. Previous works on the verification of GNM, which still lacks experimental demonstration, required a quantum circuit with O(n5) group oracle calls. Here, we provide an efficient way to verify GNM problems, in which each quantum circuit only contains O(1) group of oracle calls, and the number of qubits in each circuit is reduced by half. Based on this protocol, we then experimentally demonstrate the new verification process with a four-element group in an all-optical circuit. The new protocol is validated experimentally by observing a significant completeness-soundness gap between the probabilities of accepting elements in and outside the subgroup. This work efficiently simplifies the verification of GNM and is helpful in constructing more quantum protocols based on the near-term quantum devices.
Biodegradable Ultrasmall‐in‐Nano Gold Architectures: Mid‐Period In Vivo Distribution and Excretion Assessment

The persistence of metals in the body after the designed theranostic action has hampered the clinical translation of noble metal nanoparticles (NPs) to clinics. Therefore, the appealing behaviors of NPs for healthcare applications are still on the bench‐side. Here, quantitative evaluation in healthy murine models show that gold comprised in passion fruit‐like nanoarchitectures (NAs) are excreted daily over a 10 d period by both renal and biliary pathways after biodegradation to the building blocks. Furthermore, histological analyses confirm the absence of nephrotoxicity and the remarkable biocompatibility of NAs up to the higher tested amount of 150 mg kg−1. These in vivo findings demonstrate that NAs are the first full‐inorganic disassembling nanoplatforms exhibiting a noticeable excretion rate from model organisms. Such results are a significant step in bringing noble metal nanotheranostics to the forefront of cancer treatments once again.
Determinants of innovation by agri-food firms in rural Spain: an MCA PLS-SEM analysis

The development of a sustainable rural world must have an innovative agri-food industry as one of its bases. This article offers a comprehensive analysis of the main drivers of innovation by small and medium agri-food companies in Spain. A combined multiple correspondence analysis (MCA) and structural equation modelling (PLS-SEM) is performed to identify the key factors among 63 indicators in the domains of the technology-organisation-environmental approach. The results suggest an open field of research. Positively related to innovation are firm capacities and financial resources. Moreover, agri-food firms innovate in products, processes or marketing in order to increase sales, enter new markets, or increase the quality of their products. On the contrary, most of these firms did not innovate to reduce costs or time of response, meet regulatory compliance or maintain employment. Authorities should be aware that smaller and younger agri-food firms face more restrictions to innovate, and firms feel public policies could help to meet market demand as a driving force of innovation. On the contrary, essential objectives of regional development such as environmental compliance and maintaining employment seem to depend solely on public action.
The Impact of the Introduction of Index Futures on the Daily Returns Anomaly in the Ho Chi Minh Stock Exchange

This study investigated the impact of the introduction of the VN30-Index futures contract on the daily returns anomaly for the Ho Chi Minh Stock Exchange (HOSE). Daily returns of the VN30-Index for the period 6 February 2012 through 31 December 2019 are used in this study to ascertain the new VN30-Index futures contract influence on the day-of-the-week anomaly observed in the HOSE. To test this effect, ordinary least square (OLS), generalized autoregressive conditional heteroskedasticity [GARCH (1,1)] and exponential generalized autoregressive conditional heteroskedasticity [EGARCH (1,1)] regression models were employed. The empirical results obtained from the models support the presence of the day-of-the-week effect for the HOSE during the study period. Specifically, a negative effect was observed for Monday. However, the analysis revealed that the day-of-the-week effect was only present in stock returns for the pre-index futures period, not for the post-index futures period. These findings suggest that the introduction of the VN30-Index futures contract had a significant impact on the daily returns anomaly in Vietnam’s HOSE, providing evidence that the introduction of the index futures contract facilitated market efficiency.
SBMLWebApp: Web-based Simulation, Steady-State Analysis, and Parameter Estimation of Systems Biology Models

In systems biology, biological phenomena are often modeled by ODE and distributed in the de facto standard file format SBML. The primary analyses performed with such models are dynamic simulation, steady-state analysis, and parameter estimation. These methodologies are mathematically formalized, and libraries for such analyses have been published. Several tools exist to create, simulate, or visualize models encoded in SBML. However, setting up and establishing analysis environments is a crucial hurdle for non-modelers. Therefore, easy access to perform fundamental analyses of ODE models is a significant challenge. We developed SBMLWebApp, a web-based service to execute SBML-based simulations, steady-state analysis, and parameter estimation directly in the browser without the need for any setup or prior knowledge to address this issue. SBMLWebApp visualizes the result and numerical table of each analysis and provides a download of the results. SBMLWebApp allows users to select and analyze SBML models directly from the BioModels Database. Taken together, SBMLWebApp provides barrier-free access to an SBML analysis environment for simulation, steady-state analysis, and parameter estimation for SBML models. SBMLWebApp is implemented in Java™ based on an Apache Tomcat® web server using COPASI, the SBSCL, and LibSBMLSim as simulation engines. SBMLWebApp is licensed under MIT with source code available from https://github.com/TakahiroYamada/SBMLWebApp. The program runs online at http://simulate-biology.org.
Determination of Catechol by Cetyltrimethylammonium Bromide Functionalized Graphene Modified Electrode

A simple and sensitive electrochemical sensor was prepared by using electrodeposition of the cetyltrimethylammonium Bromide (CTMAB ) functionalized Graphene (GR) on the glassy carbon electrode (GCE) to determine Catechol (CC) in water. The performance of the CTMAB functionalized GR sensor was studied and the analysis conditions of the CC were optimized. The experimental results showed that, compared with bare GCE, the redox peak current of CC on the modified electrode was obviously enhanced. Under the optimized conditions, the oxidation and reduction peak current all showed a good linear relationship with the concentration of CC from 5μmol/L to 1000 μmol/L. The detection limit of oxidation peak is 2.92 μmol/L, and that of reduction peak is 2.44 μmol/L. The recovery was founded to be in the range of 92.70 %～101.80 %. Moreover, the sensor could be used for the determination of CC in real samples with satisfactory results. And the mechanism of the sensitization of CC detected by CTMAB-GR modified GCE was discussed preliminarily.
From early to late adolescence: Effect of problematic mobile phone use on depression of adolescents

Problematic mobile phone use can predict depression in adolescents, but few studies have thoroughly explored its internal mechanism. This study surveyed 1,768 Chinese adolescents in three educational levels (upper grades of elementary, junior middle, and high school levels) using a questionnaire. Results showed that (1) problematic mobile phone use significantly positively predicted adolescents’ depression after controlling for gender and age, (2) parent–child relationship played a mediating role between problematic mobile phone use and adolescents’ depression, and (3) adolescents’ educational level moderated relationships between problematic mobile phone use and parent–child relationship as well as parent–child relationship and depression. The negative effect of problematic mobile phone use on the parent–child relationship and the impact of the parent–child relationship on depression are weakened as the educational level of adolescents increases. These findings indicated that problematic mobile phone use affects adolescents’ depression by reducing the quality of parent–child relationship, wherein the degree of influence reduces at high educational levels. Limitations and future directions of this study were also discussed.
The Influence of Trait Empathy on Implicit Altruism

The influence of empathy on personal altruism is a hot topic in international research in recent years. Through combing the previous studies on empathy and altruism, it is found that those studies get contradictory results. Therefore, in this study, implicit association text were used to explore whether there are differences in implicit altruism among people with different empathy abilities. According to the average score of Interpersonal Reactivity Index, 67 subjects were divided into high empathy group and low empathy group. The accuracy, response time and IAT effect (response time of incompatible task less response time of compatible task ) of the implicit altruism experiment were compared between the two groups. The results showed that compared with the incompatible tasks, the compatible task had higher accuracy and shorter response time. In addition, the IAT effect of the high empathy group was significantly greater than that of the low empathy group, indicating that the higher the empathy was, the more automatic the altruistic tendency was. This study provides some supporting evidence for the promotion of altruistic behavior by empathic education.
Expiratory Flow Limitation and Its Relation to Dyspnea and Lung Hyperinflation in Patients with Chronic Obstructive Pulmonary Disease: Analysis Using the Forced Expiratory Flow-Volume Curve and Critique

Background: Tidal expiratory flow limitation (tEFL) is defined as absence of increase in air flow during forced expiration compared to tidal breathing and is related to dyspnea at rest and minimal exertion in patients with chronic airflow limitation (CAL). Tidal EFL has not been expressed as a continuous variable (0% - 100%) in previous analyses. Objective: To relate the magnitude of tEFL to spirometric values and Modified Medical Research Council (MMRC) score and Asthma Control Test (ACT). Methods: Tidal EFL was computed as percent of the tidal volume (0% - 100%) spanned (intersected) by the forced expiratory-volume curve. Results: Of 353 patients screened, 192 (114 M, 78 F) patients (136 with COPD, 56 with asthma) had CAL. Overall characteristics: (mean ± SD) age 59 ± 11 years, BMI 28 ± 7, FVC (% pred) 85 ± 20, FEV1 (% pred) 66 ± 21, FEV1/FVC 55% ± 10%, RV (% pred) 147 ± 42. Tidal EFL in patients with tEFL was 53% ± 39%. Using univariate analysis, strongest correlations were between tEFL and FVC and between tEFL and RV in patients with BMI 2. In patients with nonreversible CAL, tEFL was positively associated with increasing MMRC, negatively with spirometric measurements, and positively with RV/TLC. In asthmatics, ACT scores were higher in patients with mean BMI ≥ 28 kg/m2 (p 40% (p Conclusions: Dyspnea is strongly associated with tEFL and lung function, particularly in patients with nonreversible CAL. Air trapping and BMI contribute to tEFL.
3D Grid Transformation Network For Point Cloud Completion

Point cloud completion is of significant importance in 3D scene modeling because point clouds collected from sensors tend to be sparse and incomplete. Existing methods preferto transform2D grid points to the underlying surface of output point clouds. However, the point clouds they complete commonly retain the original plane structure and fail to recover details. To solve the problem, we propose 3D Grid Transformation Network. Unlike transforming 3 D grid points to point clouds directly, we calculate their weights for the reconstructed point clouds. Our method can break the topology of the 3D grid structure and make the underlying shape of output point clouds closer to the ground truth. We validate our method on point cloud completion and experimental results show that our method can achieve better quantitative results and obtain fine-grained details.