Miracle-dz/UniFAR-FTUs huggingface dataset:
Um Sistema e-Health Inteligente para Análise e Detecção de Doenças Cardíacas

A indústria de cuidados médicos vem evoluindo a sua prestação de serviços, focando na qualidade do atendimento ao paciente. Tem-se então a necessidade de uma infraestrutura para monitoramento da saúde dos pacientes a partir da análise dos dados destes pacientes, com intuito de detectar possíveis doenças, dentre elas, doenças cardíacas. Dentro deste contexto, este artigo apresenta um sistema e-Health inteligente para analisar os dados biológicos dos pacientes e detectar possíveis complicações cardíacas. No sistema proposto aplica-se três fases: (I) trata-se os dados através de filtros; (II) técnicas para extração das informações úteis; e, (III) os dados são analisados e classificados para detectar doenças cardíacas. Os experimentos realizados utilizando-se uma base dados real mostram que o sistema proposto é capaz de classificar com alta acurácia as anomalias cardíacas.
Repair of Knee Ligaments in Dogs: I. The Lateral Collateral Ligament

The experiment was undertaken in response to the three questions previously posed. We believe that these questions have been satisfactorily if not completely answered: 1. When the ends of a ruptured ligament are in approximation, healing occurs by an orderly process: first, by necrosis and cellular infiltration, then by fibroblastic invasion, and finally, by collagenization. If the ligament ends are not in close approximation, this orderly process does not occur and healing is by diffuse extensive scar formation. As time passes, the scar at the site of rupture becomes more orderly and its structure begins to resemble that of a normal ligament. Up to ten weeks, however, this scar had not become normal ligament even under the most favorable circumstances. Possibly, normal ligament would have developed if the process had been followed longer. 2. The most favorable circumstance for repair is end-to-end direct apposition of ligament fibers. This minimizes scarring, accelerates repair, hastens collagenization, and produces the most normal-appearing healed ligament. 3. Tests of the tensile strength of the divided lateral collateral ligament in our dogs suggest that after six or more weeks of immobilization, the strength of the attachment of the ligament to bone is diminished, presumably as the result of the atrophy of disuse. It would appear that during the first few weeks after such immobilization, care should be taken to prevent damage to this weakened area. This will need further confirmatory work.
Genetic regulation of virulence factors contributing to colonization and pathogenesis of helicobacter pylori

Helicobacter pylori is a gram-negative, microaerophilic bacterium that colonizes the human stomach. It is the causative agent of gastritis, gastric ulcers, and stomach cancer. Elucidation of the mechanisms by which H. pylori is able to colonize and persist in the stomach is the scope of much of the research being done concerning H. pylori. The central focus of the research presented in this dissertation involves the study of two factors implicated in colonization: the urease enzyme and the lipopolysaccharide (LPS) of H. pylori. Urease catalyzes the degradation of urea into ammonia and carbon dioxide. Urease is believed to function in protecting the bacterium from the acidic environment until it crosses the gastric mucosa. Our lab has demonstrated that urease is essential for colonization. The second chapter of this dissertation seeks to establish a link between the level of urease expression with the loss of colonization potential of H. pylori isolated from infected piglets and subjected to rounds of in vitro passage. Analysis of total RNA obtained from the H. pylori isolates was performed using the slot blot technique, the Northern ELISA method and reverse transcription polymerase chain reaction (RT-PCR) using a thermocycler with real-time analysis capabilities. The results from both the slot blot and RT-PCR anaylsis indicated that urease RNA is
The complete chloroplast genome of a medicinal plant, Wikstroemia chamaedaphne (Thymelaeaceae)

Abstract The first complete chloroplast genome of Wikstroemia chamaedaphne, a poisonous shrub with important medicinal value, is reported in this study. The plastome is a quadripartite circular shape with 173,042 bp in length. It consists of a large single-copy (LSC) region of 86,330 bp and a small single-copy (SSC) region of 2868 bp, separated by two inverted repeat (IR) regions of 41,922 bp each. The chloroplast genome contains 137 genes, including 91 protein-coding genes, 38 tRNA genes, and 8 rRNA genes. The GC content values in the whole cp genome, LSC region, SSC region, and IR region are 36.6%, 34.6%, 28.3%, and 38.9%, respectively. The corresponding numbers of mono-, di-, tri-, tetra- and penta-nucleotides SSRs were 73, 13, 9, 13, and 1. Phylogenetic study revealed that W. chamaedaphne and W. indica formed a monophyletic branch and having a close relationship with Stellera chamaejasme.
Asymmetric Spectral clustering

This report presents the mathematical foundation of the asymmetric spectral clustering approach given in the thesis of S.E. Atev (University of Wisconsin, 2011). This method, implemented in a companion R package AsymmetricClustering, is based on a Riemannian conjugate gradient algorithm to find a minimization problem based on an optimization problem involving unitary matrix.
Bugårdsdammen in the perspective of alternative stable states

The topic of this thesis is conditions of a shallow lake where extent of aquatic plants is considered problematic. The aim is to identify possible drivers for mass-development of broad-leaved pondweed in Bugårdsdammen. The lake is managed by Sandefjord municipality. The municipality has received concerns from the public about mass development of aquatic plants in the lake and wish to increase the open water. To identify possible drivers for mass-development chemical and physical conditions in the lake has been measured. Water and plant content have been analysed. A time series ranging from the 1950s to 2018 was constructed to map the change in plant-cover. The lake is shallow (average depth >1m.) and the theory of alternative stable states in shallow lakes is considered particularly relevant in interpreting the collected data. Analysis and estimated of external nutrient load indicate that the aquatic plants and filamentous algae is playing a crucial role in keeping the lake in a clear-water state. sammendrag: Denne masteroppgaven handler om tilstanden til en grunn innsjø, hvor vannplanters utbredelse anses som problematisk. Målet med denne masteroppgaven er å identifisere drivere for utbredelse av tjønnaks i Bugårdsdammen i Sandefjord kommune. Dammen forvaltes av kommunen, som har mottatt en rekke henvendelser for gjengroing av dammen. Kommunen ønsker å identifisere årsaker til gjengroing for å kunne gjøre tiltak som vil gi mer åpent vann i dammen. I arbeidet med å identifisere drivere for gjengroing er fysiske og kjemiske forhold blitt kartlagt. Det er gjort analyser av vannprøver og plantemateriale. En tidsserie fra 1950-tallet til 2018 er laget for å kartlegge endringer i utbredelse av vannplanter i dammen. Bugårdsdammen er en grunn innsjø (gjennomsnittsdybde > 1m.). Teorien om alternative stabile stadier i grunne innsjøer anses derfor som særlig relevant for tolkning av dataene som har bilt samlet inn. Analyser av vannprøver og estimert ekstern næringsbelastning tyder på at dammen er eutrofiert og at vannplanter og trådalger spiller en viktig rolle i å motvirke et skifte til et plankton-dominert grumsete stadium. Table of contents
Complete chloroplast genome sequence of Sophora japonica ‘JinhuaiJ2’ (Papilionaceae), an important traditional chinese herb

Abstract Sophora japonica ‘JinhuaiJ2’ (Papilionaceae), known as Chinese Scholar Tree, is an important traditional herb with a long history of cultivation in China. It’s well known for its valuable medicinal values due to its flower buds contains abundant rutin. Here, we reported and characterized its complete chloroplast genome based on Illumina paired-end sequencing data. The complete plastid genome was 158,690 bp, which contained inverted repeats (IR) of 25,339 bp separated by a large single-copy (LSC) and a small single copy (SSC) of 88,978 bp and 19,034 bp, respectively. The cpDNA contains 129 genes, comprising 83 protein-coding genes, 38 tRNA genes and 8 rRNA genes. The overall GC content of the plastome is 36.1%. The phylogenetic analysis of 18 selected chloroplast genomes demonstrated that S. japonica ‘JinhuaiJ2’ was close to the species Tapiscia sinensis.
PROVING PROPERTIES OF DISCRETE-VALUED FUNCTIONS USING DEDUCTIVE PROOF: APPLICATION TO THE SQUARE ROOT

For many years, automotive embedded systems have been validated only by testing. In the near future, Advanced Driver Assistance Systems (ADAS) will take a greater part in the car’s software design and development. Furthermore, their increasing critical level may lead authorities to require a certiﬁcation for those systems. We think that bringing formal proof in their development can help establishing safety properties and get an eﬃcient certiﬁcation process. Other industries (e.g. aerospace, railway, nuclear) that produce critical systems requiring certiﬁcation also took the path of formal veriﬁcation techniques. One of these techniques is deductive proof . It can give a higher level of conﬁdence in proving critical safety properties and even avoid unit testing. In this paper, we chose a production use case: a function calculating a square root by linear interpolation. We use deductive proof to prove its correctness and show the limitations we encountered with the oﬀ-the-shelf tools. We propose approaches to overcome some limitations of these tools and succeed with the proof. These approaches can be applied to similar problems, which are frequent in the automotive embedded software. to the correctness of the we some with the nonlinear formula of the linear interpolation. Three non-standard approaches worked well for the use of in the direct SMT-LIB quantiﬁer-free output of Frama-C and the static analysis with Astr´ee. Bit-vectors are well supported in most modern SMT solvers and are well suited for problems that involve modular arithmetic, but scaling is sometimes diﬃcult. For our use case, SMT requests without quantiﬁers performed and scaled better because there was no need for bit-vectors. Abstract Interpretation analysis gave more conﬁdence in proving that there was no overﬂow in the linear interpolation calculus. We have proposed a methodology to use a combination of these diﬀerent methods until the proof is done. We also show that using industrial use cases with oﬀ-the-shelf tools does not always scale, but if we work with we can a solution and improve the tools.
Bandwidth Improvement of MMIC Single-Pole-Double-Throw Passive HEMT Switches with Radial Stubs in Impedance-Transformation Networks

In this paper, we propose a new configuration for improving the isolation bandwidth of MMIC single-pole-double-throw (SPDT) passive high-electron-mobility transistor (HEMT) switches operating at millimeter frequency range. While the conventional configuration adopted open-stub loading for compensation of the off-state capacitance, radial stubs were introduced in our approach to improve the operational bandwidth of the SPDT switch. Implemented in 0.15 m GaAs pHEMT technology, the proposed configuration exhibited a measured insertion loss of less than 2.5 dB with better than 30 dB isolation level over the frequency range from 33 GHz to 44 GHz. In terms of the bandwidth of operation, the proposed configuration achieved a fractional bandwidth of 28.5% compared to that of 12.3% for the conventional approach. Such superior bandwidth performance is mainly attributed to the less frequency dependent nature of the radial stubs.
Prevalence of intestinal helminths among primary school children in Ihumudumu Community, Ekpoma, Edo, Nigeria

A survey of intestinal helminth parasites among school pupils was conducted in two primary schools within Ihumudumu community of Ekpoma, in Esan West Local Government Area of Edo State, Nigeria, between December 2012 and February 2013. A total of 380 faecal samples were randomly collected from pupils of both sexes whose ages ranged between 5-14 years. Using the direct wet smear and formol-ether sedimentation techniques to process the faeces, 71(18.7%) of the samples were found positive for various intestinal helminths; with Hookworm accounting for 8.4% of total number examined. Ascaris lumbricoides was 3.4%, Trichuris trichiura 2.6%, Enterobius vermicularis 1.1%, Schistosoma mansoni 0.8% , Strongyloides stercoralis 0.8%, and Fasciola spp. 0.5%. Mixed infections were observed in 4(1.1%) of the pupils. Sex did not significantly affect the pattern of infection (P>0.05) but age affected it significantly (P<0.05). Infections were detected in both schools with the difference being statistically significant (p < 0.05). Our findings indicated that intestinal helminthiasis was relatively not prevalent in the area, and as such, control and preventive measures such as chemotherapy, provision of adequate sanitary facilities and potable drinking water, improved personal hygiene and Health education should be the focus of government and non-governmental Health providers. Keywords: Prevalence, Intestinal helminthes, Parasites, School children
A snapshot across Europe: policies, interventions and actions on health literacy improvement in Europe uncovered in the HEALIT4EU study.

In a recent EU study (HEALIT4EU) evidence-based interventions and policies and programs to improve health literacy in European Member States were inventoried. From a systematic literature review we learned that evidence-based interventions of which the effectiveness is studied are virtually lacking in Europe. Only 20 studies could be retrieved. Nevertheless, health literacy as a policy topic has gained attention in the European Member States during recent years, especially in Western Europe and countries that were involved in the HLSEU study. In our study, 82 programmes and activities on health literacy in Europe were identified. In many countries, however, the concept of health literacy has not ‘caught on’ yet. In general, most countries are still in the early stages of addressing health literacy. Only six European Member States actually have a national policy or programme on health literacy. Initiatives in countries are often fragmented, largely depending on specific stakeholders, good will and enthusiastic initiatives and accidental funding. This can result in less effective use of means and fewer exchange of knowledge and ‘best practices’ as desirable. In general, a more programmatic and evidence-based policy to health literacy in EU Member States will be beneficial with regard to the outcomes of these efforts. (aut. ref.)
Rapid event-related, BOLD, NHP: choose two out of three

Human functional magnetic resonance imaging (fMRI) typically employs the blood-oxygen-level-dependent (BOLD) contrast mechanism. In non-human primates (NHP), contrast enhancement is possible using monocrystalline iron-oxide nanoparticles (MION) contrast agent, which has a more temporally extended response function. However, using BOLD fMRI in NHP is desirable for interspecies comparison, and the faster response of the BOLD signal promises to be beneficial to rapid event-related (rER) designs. Here, we used rER BOLD fMRI in macaque monkeys while viewing real-world images, and found visual responses and category-selectivity consistent with previous studies. However, activity estimates were very noisy, suggesting that the lower contrast-to-noise ratio of BOLD, suboptimal behavioural performance, and motion artefacts, in combination, render rER BOLD fMRI challenging in NHP. Previous studies have shown that rER monkey fMRI is possible with MION, despite its prolonged response function. To understand this, we conducted simulations of the BOLD and MION response during rER designs, and found that no matter how fast the design, the greater amplitude of the MION response outweighs the contrast loss caused by greater temporal smoothing. We conclude that although any two of the three elements (rER, BOLD, NHP) have been shown to work well, the combination of all three is particularly challenging.
Crustal and Upper Mantle Shear Wave Velocity Structure of Botswana: The 3 April 2017 Central Botswana Earthquake Linked to the East African Rift System

Rayleigh wave group and phase velocity measurements obtained from ambient noise and earthquake data at 51 broadband stations were used to construct the first 3‐D crustal and upper mantle shear wave velocity model of Botswana. The model shows low crustal velocities associated with the Passarge and Nosop sedimentary basins, whereas the Kaapvaal, Zimbabwe, Maltahohe, and Congo Cratons are recognized by high mantle velocities. The lowest upper mantle shear wave velocity, beneath northeastern Botswana, is associated with the southwestern branch of the East African Rift System. This low‐velocity mantle anomaly appears to be linked to the crust of the Okavango Rift Zone and the location of the 3 April 2017 Mw 6.5 earthquake in central Botswana. We suggest that fluids or melt at the base of the crust from the southward continuation of the East African Rift Zone triggered the intraplate earthquake in an extensional tectonic setting.
Correlative Fluorescence- and Electron Microscopy of Whole Breast Cancer Cells Reveals Different Distribution of ErbB2 Dependent on Underlying Actin

Epidermal growth factor receptor 2 (ErbB2) is found overexpressed in several cancers, such as gastric, and breast cancer, and is, therefore, an important therapeutic target. ErbB2 plays a central role in cancer cell invasiveness, and is associated with cytoskeletal reorganization. In order to study the spatial correlation of single ErbB2 proteins and actin filaments, we applied correlative fluorescence microscopy, and scanning transmission electron microscopy (STEM) to image specifically labeled SKBR3 breast cancer cells. The breast cancer cells were grown on microchips, transformed to express an actin-green fluorescent protein (GFP) fusion protein, and labeled with quantum dot (QD) nanoparticles attached to specific anti-ErbB2 Affibodies. Fluorescence microscopy was performed to identify cellular regions with spatially correlated actin and ErbB2 expression. For STEM of the intact plasma membrane of whole cells, the cells were fixed and covered with graphene. Spatial distribution patterns of ErbB2 in the actin rich ruffled membrane regions were examined, and compared to adjacent actin-low regions of the same cell, revealing an association of putative signaling active ErbB2 homodimers with actin-rich regions. ErbB2 homodimers were found absent from actin-low membrane regions, as well as after treatment of cells with Cytochalasin D, which breaks up larger actin filaments. In both latter data sets, a significant inter-label distance of 36 nm was identified, possibly indicating an indirect attachment to helical actin filaments via the formation of heterodimers of ErbB2 with epidermal growth factor receptor (EGFR). The possible attachment to actin filaments was further explored by identifying linear QD-chains in actin-rich regions, which also showed an inter-label distance of 36 nm.
Simplified Hybrid Secure Algorithm for Mobile Banking Application

M-banking is one of the main divisions of m-commerce. It provides daily banking operations to the customer using his mobile with the supported application. But the current applications are facing security challenges due to the limitations of mobile resources. There are two major schemes. First, the public key infrastructure (PKI) but, suffers the scalability and certificate management problems. Second, the identity-based public key cryptography (IBPKC) but has key escrow problem. In this paper a modified algorithm to solve these problems by combining elliptic curve Signcryption with certificateless cryptography and enhance the security with lower computational time. From the results, the proposed algorithm has superior performance compared with earlier schemes. Also, it supports multiple types of messages (such as document and multimedia).
The Nature and Extent of Social Anxiety and Avoidance in Patients with Chronic Pain

The present study explored the nature and extent of social anxiety and avoidance, anxiety sensitivity, and pain-related anxiety and avoidance in 46 clinic-referred chronic pain patients, compared with a community-based group reporting pain (n = 66) and healthy controls (n = 57). The chronic pain patients consistently reported higher levels of social distress, social avoidance, fear of negative evaluation, anxiety sensitivity, and pain-related anxiety and avoidance as compared with controls. Group differences in social distress, social avoidance, fear of negative evaluation, pain-related cognitive anxiety, and fear of cognitive and emotional dyscontrol, remained stable when pain severity was controlled for. Anxiety sensitivity was strongly related to both social and pain-related fears. The source of these social fears is examined in relation to the elevated pain-related fear and anxiety sensitivity also exhibited by chronic pain patients, and implications for treatment and rehabilitation are discussed.
A Nonlinear Energy Harvester Operated in the Stochastic Resonance Regime for Signal Detection/Measurement Applications

An energy harvester can operate as a sensor. This article investigates the behavior of a snap-through buckling beam, which underpins a nonlinear vibrational energy harvester (NLEH), in the presence of noisy vibrations superimposed on a subthreshold deterministic input signal. In particular, we concentrate on a specific operating regime, in which noise-mediated cooperative behavior, specifically “stochastic resonance” (SR), can be exploited in signal detection scenarios. We consider a sinusoidal signal with amplitude below the switching threshold of the NLEH, i.e., the signal alone does not lead to switching between the stable states of the NLEH. As expected, there exists an optimal noise intensity at which the response signal-to-noise ratio (SNR) passes through a maximum, the hallmark of the SR effect. The harvesting performance, quantified by the generated electrical power and the mechanical–electrical conversion efficiency, is examined as a function of the amplitude/frequency of the deterministic signal, and the noise intensity. Realizing that both the SR effect and the most efficient energy-harvesting (EH) behavior depend on the rate of switching events across the energy barrier of the device, we find that “tuning” to the SR regime does, in fact, improve signal detection, as should be expected. However, the EH performance improves with larger noise values. Therefore, the regimes for optimal signal detection and highest electrical power generation are different, with increasing noise intensity yielding better EH performance. There does exist, however, the intriguing possibility that, by carefully configuring the electrical stage of the NLEH, one could realize an autonomous sensor that collects electrical power to charge a capacitor and utilizes it to power the electronics for signal detection/analysis in the SR regime.