Miracle-dz/UniFAR-FTUs huggingface dataset:
Emotional Processing of Ironic Versus Literal Criticism in Autistic and Nonautistic Adults: Evidence From Eye‐Tracking

Typically developing adults are able to keep track of story characters' emotional states online while reading. Filik et al. showed that initially, participants expected the victim to be more hurt by ironic comments than literal, but later considered them less hurtful; ironic comments were regarded as more amusing. We examined these processes in autistic adults, since previous research has demonstrated socio‐emotional difficulties among autistic people, which may lead to problems processing irony and its related emotional processes despite an intact ability to integrate language in context. We recorded eye movements from autistic and nonautistic adults while they read narratives in which a character (the victim) was either criticized in an ironic or a literal manner by another character (the protagonist). A target sentence then either described the victim as feeling hurt/amused by the comment, or the protagonist as having intended to hurt/amused the victim by making the comment. Results from the nonautistic adults broadly replicated the key findings from Filik et al., supporting the two‐stage account. Importantly, the autistic adults did not show comparable two‐stage processing of ironic language; they did not differentiate between the emotional responses for victims or protagonists following ironic versus literal criticism. These findings suggest that autistic people experience a specific difficulty taking into account other peoples' communicative intentions (i.e., infer their mental state) to appropriately anticipate emotional responses to an ironic comment. We discuss how these difficulties might link to atypical socio‐emotional processing in autism, and the ability to maintain successful real‐life social interactions. Autism Res 2020, 13: 563–578. © 2020 International Society for Autism Research, Wiley Periodicals, Inc.
Host Range and Effects of Plant Species on Preference and Fitness of Tuta absoluta (Lepidoptera: Gelechiidae)

Abstract Tuta absoluta (Meyrick) is one of the most devastating pests of tomato in both open field and greenhouse production settings that significantly reduce yield and quality of the fruit. Being a new invasive pest, information on the pest bio-ecology, including host-rage and effects of plant species on its various fitness traits are virtually lacking. This study involved a field survey to establish the realized host range and laboratory experiments to evaluate the preference for, and fitness effects of T. absoluta on different plant species. In the field, T. absoluta was recovered from only four solanaceous plant species: tomato (Solanum lycopersicum L.), eggplant (S. melongena L.), black nightshade (S. nigrum L.), and gubbain (S. dubium Fr.). In choice and no-choice tests, tomato was the most preferred host of T. absoluta having the highest number of eggs deposited, followed by black nightshade, French bean Phaseolus vulgaris L. , and chilli pepper Capsicum frutescens. Larvae developed quickest on tomato followed by black nightshade and French bean. The percentage survival to adulthood was significantly higher on tomato, compared to survival on black nightshade and French bean. Rearing of T. absoluta on tomato or black nightshade had no significant effect on pupal mass and length as well as adult size for both sexes. Fecundity and longevity, as well as oviposition preference of T. absoluta, were not affected by rearing on different plants. These findings confirm the oligophagous nature of the pest with high preference to tomato.
Does a narrative retelling task improve the assessment of language proficiency in school-aged children born very preterm?

ABSTRACT Almost half of the children born very preterm (VP) experience language difficulties at school-age, specifically with more complex language tasks. Narrative retelling is such a task. Therefore, we explored the value of narrative retelling assessment in school-aged children born VP, compared to item-based language assessment. In 63 children born VP and 30 age-matched full-term (FT) controls Renfrew’s Bus Story Test and Clinical Evaluation of Language Fundamentals were assessed. The retelling of the Bus Story was transcribed and language complexity and content measures were analyzed with Computerised Language Analysis software. Narrative outcomes of the VP group were worse than that of the FT group. Group differences were significant for the language complexity measures, but not for the language content measures. However, the mean narrative composite score of the VP group was significantly better than their mean item-based language score, while in the FT group the narrative score was worse than the item-based score. Significant positive correlations between narrative and item-based language scores were found only in the VP group. In conclusion, in VP children narrative retelling appears to be less sensitive to detecting academic language problems than item-based language assessment. This might be related to the mediating role of attention in item-based tasks, that appears not to affect more spontaneous language tasks such as retelling. Therefore, in school-aged children born VP we recommend using narrative assessment, in addition to item-based assessments, because it is more related to spontaneous language and less sensitive to attention problems.
Self-Compassion and Need Frustration Moderate the Effects of Upward Appearance Comparisons on Body Image Discrepancies

Abstract Drawing from diverse theoretical frameworks, we examined predictors of discrepancy between current and ideal body image in a sample of 396 Greek adolescents. The participants completed assessments of the frequency of comparing oneself with someone of perceived better appearance, appearance evaluations, frustration of basic psychological needs, and appearance self-compassion. We found that upward appearance comparisons negatively predicted appearance evaluation, which in turn was a negative predictor of body image discrepancy. Moderated mediation analyses showed that appearance self-compassion buffered, whereas psychological need frustration augmented the negative effects of upward comparisons on appearance evaluation. Our findings contribute to the growing literature on body image discrepancies in adolescence by examining moderating factors that amplify or buffer such discrepancies, hence identifying viable intervention pathways.
Prenatal and Peripartum Exposure to Antibiotics and Cesarean Section Delivery Are Associated with Differences in Diversity and Composition of the Infant Meconium Microbiome

The meconium microbiome may provide insight into intrauterine and peripartum exposures and the very earliest intestinal pioneering microbes. Prenatal antibiotics have been associated with later obesity in children, which is thought to be driven by microbiome dependent mechanisms. However, there is little data regarding associations of prenatal or peripartum antibiotic exposure, with or without cesarean section (CS), with the features of the meconium microbiome. In this study, 16S ribosomal RNA gene sequencing was performed on bacterial DNA of meconium samples from 105 infants in a birth cohort study. After multivariable adjustment, delivery mode (p = 0.044), prenatal antibiotic use (p = 0.005) and peripartum antibiotic use (p < 0.001) were associated with beta diversity of the infant meconium microbiome. CS (vs. vaginal delivery) and peripartum antibiotics were also associated with greater alpha diversity of the meconium microbiome (Shannon and Simpson, p < 0.05). Meconium from infants born by CS (vs. vaginal delivery) had lower relative abundance of the genus Escherichia (p < 0.001). Prenatal antibiotic use and peripartum antibiotic use (both in the overall analytic sample and when restricting to vaginally delivered infants) were associated with differential abundance of several bacterial taxa in the meconium. Bacterial taxa in the meconium microbiome were also differentially associated with infant excess weight at 12 months of age, however, sample size was limited for this comparison. In conclusion, prenatal and peripartum antibiotic use along with CS delivery were associated with differences in the diversity and composition of the meconium microbiome. Whether or not these differences in the meconium microbiome portend risk for long-term health outcomes warrants further exploration.
Neuropsychiatric Effects on Decision-Making in Early Alzheimer Disease

Background: Neuropsychiatric symptoms can impact decision-making in patients with Alzheimer disease (AD). Methods: Using a simple decision-making task, a variant of the ultimatum game (UG) modified to control feelings of unfairness, this study investigated rejection responses among responders to unfair offers. The UG was administered to 11 patients with AD, 10 comparably demented patients with behavioral variant frontotemporal dementia (bvFTD), and 9 healthy controls (HC). The results were further compared with differences on the caregiver Neuropsychiatric Inventory (NPI). Results: Overall, patients with AD significantly rejected more total offers than did the patients with bvFTD and the HC (P < .01). On the NPI, the only domain that was significantly worse among the patients with AD compared to the other groups was dysphoria/depression. Conclusions: These results suggest that early AD can be distinguished based on increased rejections of offers in decision-making, possibly consequent to a heightened sense of unfairness from dysphoria/depression.
The Effects of an Intensive Evidence-Based Practice Educational and Skills Building Program on EBP Competency and Attributes.

BACKGROUND AND SIGNIFICANCE Evidence-based practice (EBP) is a systematic problem-solving approach to the delivery of health care that improves quality and population health outcomes as well as reduces costs and empowers clinicians to fully engage in their role, otherwise known as the quadruple aim in health care. The Helene Fuld Health Trust National Institute for Evidence-based Practice in Nursing and Healthcare at The Ohio State University College of Nursing has been offering 5-day EBP immersion programs since 2012. The goal of the program is for the participants to acquire EBP competence (e.g., knowledge, skills, and attitude) and sustain it over time. PURPOSE AND AIMS The purpose of this study was to evaluate the effects of the 5-day EBP immersion (i.e., an education and skills building program) on EBP attributes and competence over time. METHOD AND DESIGN A longitudinal pre-experimental study was conducted that gathered data with an anonymous online survey from 400 program attendees who attended 16 5-day immersions between September 2014 and May 2016. Participants completed five valid and reliable instruments at four points over 12 months, including EBP beliefs, implementation, competency, knowledge, and perception of organizational readiness and culture. RESULTS Findings indicated statistically significant improvements in EBP attributes and competency over time. The results of this study support the hypotheses that EBP competency and attributes can be significantly improved and sustained by attending an intensive 5-day EBP educational and skills building program such as the one described in this study. This study can help leaders and organizations to mitigate many of the traditional barriers to EBP. LINKING EVIDENCE TO ACTION The results of this study indicate that EBP attributes and competencies can be improved and sustained by attending an intensive 5-day EBP immersion, regardless of clinicians' prior educational preparation.
Dental Implants in Patients with Oral Lichen Planus: A Systematic Review

Background and Objectives: To integrate the available published data on patients with oral lichen planus (OLP) rehabilitated with dental implants, as well as to review the recommendations for OLP patients receiving implants. Materials and Methods: An electronic search was undertaken in February 2019 using five databases. Publications reporting cases of patients with OLP and rehabilitated with implant-supported oral prosthesis were included. Results: Twenty-two publications were included (230 patients, 615 implants). The overall implant failure rate was 13.9% (85/610). In patients with oral squamous cell carcinoma (OSCC) the failure rate was 90.6% (29/32), but none of these implants lost osseointegration; instead, the implants were removed together with the tumor. One study presented a very high implant failure rate, 76.4% (42/55), in patients with “active lichen planus”, with all implants failing between 7–16 weeks after implant placement, and its conflicting and incongruent results are discussed in detail. There was a statistically significant difference between the failure rates in implants installed in different jaws (maxilla/mandible) and when implants of different surfaces were used (turned/moderately rough), but not between patients with reticular or erosive OLP types, or between male and female patients. If OSCC patients and the cases of the latter study are not considered, then the failure rate becomes very low (2.7%, 14/523). The time between implant placement and failure was 25.4 ± 32.6 months (range 1–112). The mean ± SD follow-up was 58.9 ± 26.7 months (1–180). Conclusions: When the results of the one study with a very high failure rate and of the cases that developed OSCC are not considered, the dental implant failure rate in OLP patients was 2.7% after a follow-up of approximately five years. Recommendations are given when treating OLP patients with dental implants.
Mortality in a neonate with molybdenum cofactor deficiency illustrates the need for a comprehensive rapid precision medicine system

Neonatal encephalopathy with seizures is a presentation in which rapid whole-genome sequencing (rWGS) has shown clinical utility and improved outcomes. We report a neonate who presented on the third day of life with seizures refractory to antiepileptic medications and neurologic and computerized tomographic findings consistent with severe generalized brain swelling. rWGS revealed compound heterozygous variants in the molybdenum cofactor synthesis gene, type 1A (MOCS1 c.*7 + 5G > A and c.377G > A); a provisional diagnosis of molybdenum cofactor deficiency on day of life 4. An emergency investigational new drug application for intravenous replacement of the MOCS1 product, cyclic pyranopterin monophosphate, was considered, but felt unsuitable in light of the severity of disease and delay in the start of treatment. The patient died on day of life 9 despite having a precise molecular diagnosis within the first week of life. This case illustrates that an rWGS-based molecular diagnosis within the first week of life may be insufficient to improve outcomes. However, it did inform clinical decision-making with regard to resuscitation and predicted long-term outcome. We suggest that to achieve optimal reductions in morbidity and mortality, rWGS must be implemented within a comprehensive rapid precision medicine system (CRPM). Akin to newborn screening (NBS), CRPM will have onboarding, diagnosis, and precision medicine implementation components developed in response to patient and parental needs. Education of health-care providers in a learning model in which ongoing data analyses informs system improvement will be essential for optimal effectiveness of CRPM.
Are glacial refugia hotspots of speciation and cytonuclear discordances? Answers from the genomic phylogeography of Spanish common frogs

Subdivided Pleistocene glacial refugia, best known as “refugia within refugia”, provided opportunities for diverging populations to evolve into incipient species and/or to hybridize and merge following range shifts tracking the climatic fluctuations, potentially promoting extensive cytonuclear discordances and “ghost” mtDNA lineages. Here, we tested which of these opposing evolutionary outcomes prevails in northern Iberian areas hosting multiple historical refugia of common frogs (Rana cf. temporaria), based on a genomic phylogeography approach (mtDNA barcoding and RAD‐sequencing). We found evidence for both incipient speciation events and massive cytonuclear discordances. On the one hand, populations from northwestern Spain (Galicia and Asturias, assigned to the regional endemic R. parvipalmata), are deeply‐diverged at mitochondrial and nuclear genomes (~4 My of independent evolution), and barely admix with northeastern populations (assigned to R. temporaria sensu stricto) across a narrow hybrid zone (~25 km) located in the Cantabrian Mountains, suggesting that they represent distinct species. On the other hand, the most divergent mtDNA clade, widespread in Cantabria and the Basque country, shares its nuclear genome with other R. temporaria s. s. lineages. Patterns of population expansions and isolation‐by‐distance among these populations are consistent with past mitochondrial capture and/or drift in generating and maintaining this ghost mitochondrial lineage. This remarkable case study emphasizes the complex evolutionary history that shaped the present genetic diversity of refugial populations, and stresses the need to revisit their phylogeography by genomic approaches, in order to make informed taxonomic inferences.
Randomised trial showed no difference in behavioural symptoms between surgical methods treating paediatric obstructive sleep apnoea

Our previous randomised controlled trial of children with obstructive sleep apnoea (OSA) showed no significant differences between adenotonsillectomy (ATE) and adenotonsillotomy (ATT) in improving nocturnal respiration and quality of life after 1 year. The aim of this report was to evaluate the effects on behavioural symptoms using the Strengths and Difficulties Questionnaire (SDQ).
Biological Responses of Stem Cells to Photobiomodulation Therapy.

BACKGROUND Stem cells have attracted the researchers increasing interest, due to their applications in regenerative medicine. Their self-renewal, capacity for multipotent differentiation, and immunomodulatory properties make them unique to significantly contribute in tissue repair and regeneration applications. Recently, cells have shown increased proliferation when irradiated with low level laser therapy or Photobiomodulation therapy (PBMT), which induces the activation of intracellular and extracellular chromophores and the initiation of cellular signaling. The purpose of this study was to evaluate this phenomenon in the literature. METHOD The literature investigated the articles written in English in four electronic data bases of PubMed, Scopus, Google scholar and Cochrane up to April 2019. Stem cell was searched by combining the search keyword of 'low level laser therapy' OR 'low power laser therapy' OR 'low intensity laser therapy' OR 'photobiomodulation therapy' OR 'photo biostimulation therapy' OR 'LED'. In total, 46 articles had eligibility to be evaluated. RESULTS Studies demonstrated that red to near-infrared light is absorbed by the mitochondrial respiratory chain. Mitochondria are the significant sources of reactive oxygen species (ROS). Mitochondria play an important role in metabolism, energy generation, and are also involved in mediating the effects induced by PBMT. PBMT may result in the increased production of (ROS), nitric oxide (NO), adenosine triphosphate (ATP), and cyclic adenosine monophosphate (cAMP). These changes in turn initiate cell proliferation and induce the signal cascade effect. CONCLUSION The findings of this review suggest that PBMT -based regenerative medicine could be a useful tool for future advances in tissue engineering and cell therapy.
Discovering Suspicious APT Behaviors by Analyzing DNS Activities

As sensors become more prevalent in our lives, security issues have become a major concern. In the Advanced Persistent Threat (APT) attack, the sensor has also become an important role as a transmission medium. As a relatively weak link in the network transmission process, sensor networks often become the target of attackers. Due to the characteristics of low traffic, long attack time, diverse attack methods, and real-time evolution, existing detection methods have not been able to detect them comprehensively. Current research suggests that a suspicious domain name can be obtained by analyzing the domain name resolution (DNS) request to the target network in an APT attack. In past work based on DNS log analyses, most of the work would simply calculate the characteristics of the request message or the characteristics of the response message or the feature set of the request message plus the response message, and the relationship between the response message and the request message was not considered. This may leave out the detection of some APT attacks in which the DNS resolution process is incomplete. This paper proposes a new feature that represents the relationship between a DNS request and the response message, based on a deep learning method used to analyze the DNS request records. The algorithm performs threat assessment on the DNS behavior to be detected based on the calculated suspicious value. This paper uses the data of 4, 907, 147, 146 DNS request records (376, 605, 606 records after DNS Data Pre-processing) collected in a large campus network and uses simulation attack data to verify the validity and correctness of the system. The results of the experiments show that our method achieves an average accuracy of 97.6% in detecting suspicious DNS behavior, with the orange false positive (FP) at 2.3% and the recall at 96.8%. The proposed system can effectively detect the hidden and suspicious DNS behavior in APT.
Flexural Behavior of a Precast Concrete Deck Connected with Headed GFRP Rebars and UHPC

Steel bent reinforcing bars (rebars) are widely used to provide adequate anchorage. Bent fiber-reinforced polymer (FRP) rebars are rarely used because of the difficulty faced during the bending process of the FRP rebars at the construction site. Additionally, the bending process may cause a significant decrease in the structural performance of the FRP rebars. Therefore, to overcome these drawbacks, a headed glass fiber-reinforced polymer (GFRP) rebar was developed in this study. The pull-out tests of the headed GFRP rebars with diameters of 16 and 19 mm were conducted to evaluate their bond properties in various cementitious materials. Moreover, structural flexural tests were conducted on seven precast concrete decks connected with the headed GFRP rebars and various cementitious fillers to estimate the flexural behavior of the connected decks. The results demonstrate that the concrete decks connected with the headed GFRP rebar and ultra-high-performance concrete (UHPC) exhibited improved flexural performance.
Rosemary Extract Inhibits Proliferation, Survival, Akt, and mTOR Signaling in Triple-Negative Breast Cancer Cells

Breast cancer is the most commonly diagnosed cancer in women. Triple-negative (TN) breast cancer lacks expression of estrogen receptor (ER), progesterone receptor (PR) as well as the expression and/or gene amplification of human epidermal growth factor receptor 2 (HER2). TN breast cancer is aggressive and does not respond to hormone therapy, therefore new treatments are urgently needed. Plant-derived chemicals have contributed to the establishment of chemotherapy agents. In previous studies, rosemary extract (RE) has been found to reduce cell proliferation and increase apoptosis in some cancer cell lines. However, there are very few studies examining the effects of RE in TN breast cancer. In the present study, we examined the effects of RE on TN MDA-MB-231 breast cancer cell proliferation, survival/apoptosis, Akt, and mTOR signaling. RE inhibited MDA-MB-231 cell proliferation and survival in a dose-dependent manner. Furthermore, RE inhibited the phosphorylation/activation of Akt and mTOR and enhanced the cleavage of PARP, a marker of apoptosis. Our findings indicate that RE has potent anticancer properties against TN breast cancer and modulates key signaling molecules involved in cell proliferation and survival.