Miracle-dz/UniFAR-FTUs huggingface dataset:
The Tower of Babel The Tower of Babel : Bridging Diverse Languages with Information Technologies

New digital tools or information technologies are providing the means for architects to realize unprecedented architectural creations. Unfortunately, the promise these technologies hold is far from their potential expression in the built physical environment. A contributing cause to this disjunctive state is the multiplicity of languages and knowledge sets employed by the various team members or actors engaged in a building project. From the cost models of the owners to the shop drawings of the fabricators, each actor views the project in terms specific to their individual discipline. In order to successfully engage the building process, these new technologies must account for this condition and develop means in which to span across traditional boundaries. This paper will examine the disjointed and fractured nature of the building project and identify opportunities for the deployment of information technologies to bridge boundaries, ultimately providing for and delivering architectural projects of unparalleled precedence. Specific aspects inherent to these technologies will be examined to understand where their application may benefit the building process. The key attributes this paper will focus on include: visualization tools, centralized database, cross discipline platform tools and novel forms of information representation. A case study of an architectural project will serve as the means in which to study the successful implementation of these attributes and their resulting impact on the design process and building project. This study will demonstrate how information technologies can be implemented within the multifaceted framework of conventional building projects to yield a project of unprecedented
A UNIFIED 3 D CADASTRE DATA MODEL – A GEOMETRIC APPROACH

Urbanisation creates immense competition for space due to rural-urban migration. Hence, urban or city authorities need to plan, expand and use such three dimensional (3D) space above, on and below the city space. Thus difficulties in property ownership and the geometric representation of the 3D city space is a major challenge.This research, will investigate the concept of representing a geometric topological 3D spatial model capable of representing 3D volume parcels for man-made constructions above and below the 3D surface volume parcel. The 3D TIN model is adopted. The concepts, logical and physical models of 3D TIN for 3D volumes is presented and implemented to show man-made constructions above and below the surface parcel within a user friendly graphical user interface. The 3D TIN data model is significant and can be adopted as the unified model for 3D cadastre. Countries interested in adopting 3D cadastre can also adopt this data model for the LA_Spatial part of the Land Administration Domain Model (LADM) (ISO/TC211, 2012).
California DETECTION OF ROAD DAMAGE USING THE IMAGES CAPTURED BY A VEHICLE-MOUNTED CAMERA

The Kumamoto earthquakes, which are a series of earthquakes including an event on April 16, 2016 with a moment magnitude of 7.0, caused severe damage to the road network in Kumamoto Prefecture in Kyushu Region, Japan. This study tries to detect the earthquake-induced damage to the roadways using the images captured by a vehicle-mounted camera. The images employed by this study were sequentially taken after the 2016 Kumamoto earthquake with a camera installed in an automobile. The images in the heavily affected areas, such as Mashiki Town, are also included in the image dataset. The total number of images captured on April 17 and 20 is 31,951. To achieve the objective, the authors try to develop an image classifier to detect the earthquakeinduced damage to the roadways based on deep learning algorithm. The images were visually classified into the three classes: damage to roadway, roadway closure, and no damage, and they were used as a training dataset for deep learning algorithm. A deep learning module CAFFE (convolutional architecture for fast feature embedding) was employed in this study to develop an image classifier. The image classifier detected the damage to roadway and roadway closures with the accuracy of approximately 70%. It was difficult to identify the images with no damage, and improvement of the accuracy is required for practical applications. 1 Associate Professor, Dept. of Urban Environment Systems, Chiba University, Chiba, Japan (email: ymaruyam@tu.chiba-u.ac.jp) 2 Graduate Student, Dept. of Urban Environment Systems, Chiba University, Chiba, Japan 3 Senior Researcher, Technincal Research Institute, Kajima Corporation, Tokyo, Japan Maruyama Y, Sezaki R, Nagata S. Detection of Road Damage using the Images Captured by a Vehicle-mounted Camera. Proceedings of the 11 th National Conference in Earthquake Engineering, Earthquake Engineering Research Institute, Los Angeles, CA. 2018. Detection of Road Damage using the Images Captured by a Vehicle-Mounted Camera Y. Maruyama 1 , R. Sezaki 2 and S. Nagata 3
Porting and Optimizing VERTEX-PROMETHEUS on the Cray XE 6 at HLRS for Three-Dimensional Simulations of Core-Collapse Supernova Explosions of Massive Stars

Supernova explosions are among the most powerful cosmic events, whose physical mechanism and consequences are still incompletely understood. We have developed a fully MPI-OpenMP parallelized version of our VERTEX-PROMETHEUS code in order to perform three-dimensional simulations of stellar core-collapse and explosion on Tier-0 systems such as Hermit at HLRS. Tests on up to 64000 cores have shown excellent scaling behavior. In this paper we present the system of equations and the algorithm for its solution that are employed in our code VERTEX-PROMETHEUS. We also discuss the parallelization of VERTEX-PROMETHEUS and present our progress in porting, optimizing, and performing production runs on a large variety of machines, starting from vector machines and reaching to modern systems. In particular the results of our efforts to achieve good parallel scaling on the new Cray XE6 at HLRS Stuttgart are highlighted.
The Luminal Helix l of PsaB Is Essential for Recognition of Plastocyanin or Cytochrome c 6and Fast Electron Transfer to Photosystem I in Chlamydomonas reinhardtii *

At the lumenal side of photosystem I (PSI) in cyanobacteria, algae, and vascular plants, proper recognition and binding of the donor proteins plastocyanin (pc) and cytochrome (cyt) c 6 are crucial to allow subsequent efficient electron transfer to the photooxidized primary donor. To characterize the surface regions of PSI needed for the correct binding of both donors, loop j of PsaB of Chlamydomonas reinhardtii was modified using site-directed mutagenesis and chloroplast transformation. Mutant strains D624K, E613K/D624K, E613K/W627F, and D624K/W627F accumulated <20% of PSI as compared with wild type and were only able to grow photoautotrophically at low light intensities. Mutant strains E613N, E613K, and W627F accumulated >50% of PSI as compared with wild type. This was sufficient to isolate the altered PSI and perform a detailed analysis of the electron transfer between the modified PSI and the two algal donors using flash-induced spectroscopy. Such an analysis indicated that residue Glu613 of PsaB has two functions: (i) it is crucial for an improved unbinding of the two donors from PSI, and (ii) it orientates the positively charged N-terminal domain of PsaF in a way that allows efficient binding of pc or cyt c 6 to PSI. Mutation of Trp627 to Phe completely abolishes the formation of an intermolecular electron transfer complex between pc and PSI and also drastically diminishes the rate of electron transfer between the donor and PSI. This mutation also hinders binding and electron transfer between the altered PSI and cytc 6. It causes a 10-fold increase of the half-time of electron transfer within the intermolecular complex of cytc 6 and PSI. These data strongly suggest that Trp627 is a key residue of the recognition site formed by the core of PSI for binding and electron transfer between the two soluble electron donors and the photosystem.
Versatic 10 Acid / NICKSYN TM Synergistic System versus D 2 EPHA-Cyanex 272 for the Recovery of Cobalt from Typical DRC / Zambian Copper-Cobalt Leach

The production of a premium grade cobalt requires stringent control of impurity concentrations in the cobalt advance electrolyte, in order to obtain an electrowon Co with a purity of >99.3%. Typically such a Co refining circuit would, prior to the recovery and upgrading of the Co, entail oxidative precipitation of Fe and Al, Zn, Ca and Mn removal with di-(2-ethylhexyl)phosphoric acid (D2EHPA) followed by subsequent upgrading and recovery of cobalt with bis(2,4,4-trimethylpentyl) phosphinic acid (Cyanex 272).
Two‐photon fluorescence absorption and emission spectra of dyes relevant for cell imaging

Two‐photon absorption and emission spectra for fluorophores relevant in cell imaging were measured using a 45 fs Ti:sapphire laser, a continuously tuneable optical parametric amplifier for the excitation range 580–1150 nm and an optical multichannel analyser. The measurements included DNA stains, fluorescent dyes coupled to antibodies as well as organelle trackers, e.g. Alexa and Bodipy dyes, Cy2, Cy3, DAPI, Hoechst 33342, propidium iodide, FITC and rhodamine. In accordance with the two‐photon excitation theory, the majority of the investigated fluorochromes did not reveal significant discrepancies between the two‐photon and the one‐photon emission spectra. However, a blue‐shift of the absorption maxima ranging from a few nanometres up to considerably differing courses of the spectrum was found for most fluorochromes. The potential of non‐linear laser scanning fluorescence microscopy is demonstrated here by visualizing multiple intracellular structures in living cells. Combined with 3D reconstruction techniques, this approach gives a deeper insight into the spatial relationships of subcellular organelles.
Comparison of heat outflow in dense sub-14nm contemporary NFETs: Bulk/SOI, inserted-oxide FinFET and nanowire FET

Since the invention of iFinFET devices, there has been literature suggesting various electrical and thermal improvements it could have over gate-all-around NWFETs. In this work, we have compared contemporary NFETs for 7-nm CMOS technology node for their electrical only and thermal only performance using calibrated 3-D TCAD simulations. This allowed us to simulate relatively larger device structures required for analysis of thermal behavior of these devices with ease, while we could utilize most advanced mobility models to simulate smaller device structures to address electrical performance of these devices. While electrical performance of all these devices is comparable, SOI FinFETs show at least 30 degree Kelvin higher temperature as compared to other devices in thermal simulations, while the bulk FinFETs can achieve 40 degree Kelvin lower temperature in presence of an identical thermal power source. The nanowire and iFinFET depict moderate thermal behavior in this comparison.
Optimization of the Cry 2 Aa Gene and Development of Insect-resistant and Herbicide-tolerant Photoperiod-sensitive Genic Male Sterile Rice

Weng L. , Deng L. , Lia F. , Xiao G. (2014): Optimization of the Cry2Aa gene and development of insect-resistant and herbicide-tolerant photoperiod-sensitive genic male sterile rice. Czech J. Genet. Plant Breed. , 50: 19–25. In this study, an optimized Cry2Aa gene was obtained after codon optimization based on the preferred codons in rice. The novel fusion gene Cry2Aa# was designed by adding the sequence coding the signal peptide of PR1a at the 5' end and the endoplasmic reticulum retention signal peptide KDEL at the 3' end of the optimized Cry2Aa gene, respectively. The Cry2Aa# and Bar genes were transformed into 4008S, a photoperiod-sensitive genic male sterile (PGMS) line in rice, using the Agrobacterium transfer method. A total of 65 regenerated plantlets confirmed by PCR were produced, in which eight transgenic lines had single-copy insertions as confirmed by Southern blot analysis. The high variability of Cry2Aa# gene expression was observed among independent transgenic lines with single-copy insertion, and the spatiotemporal difference of Cry2Aa protein expression was discovered in each transgenic line. The results showed that the transgenic lines were highly resistant to glufosinate, rice leaf roller and striped stem borer, which not only confirmed the effective optimization of the Cry2Aa gene but also produced a useful germplasm for breeding insect-resistant and herbicide-tolerant hybrid rice varieties.
Potentiation of pressor effect of tyramine by newly synthesized compound 2[(n- benzylacetamido) mercapto] benzimidazole (vs 25), a putative inhibitorof monoamine oxidaseâA enzyme in rats

A series of compounds were synthesized with potential of antidepressant activity. Preliminary research work indicated that monoamine oxidase inhibitor may one of the mechanism of action. Interaction of monoamine oxidase inhibitors with tyramine containing food material is known. Thus aim of the present investigation is to evaluate the pressor effect of tyramine in rats pretreated with synthesized compound (VS 25) and moclobemide. The dose response relationship to tyramine was determined by injecting tyramine i.v. in anaesthetized rats. The study protocol was divided into two parts 1 day treatment model and 14 day treatment model. In one day treatment model, saline control group showed no significant change in SBP,DBP, MABP and heart rate. In cmc control group 1st injection of tyramine showed rise in blood pressure 195.60±8.40 from initial reading of 119.82± 5.62( baseline) before tyramine and subsequent injection decreased blood pressure. Moclobemide 50 mg/kg and VS 25 (30 and 60mg/kg) significantly p<0.01 increased SBP, DBP and MABP. The 14 day treatment model showed significant potentiation of pressor effect of tyramine as compared to 1 day drug treatment model p<0.001. The heart rate decreased in both the model and on 14 day there tachycardia was observed compared to moclobemide. On comparison of 1 day and 14 day treatment model VS 25 (30 mg/kg), VS 25 (60 mg/kg) and moclobemide (50 mg/kg) showed similar rise in SBP, DBP and MABP. Both the drugs failed to prevent tyramine tachyphylaxis. While VS25 (30 mg/kg) showed significant (p<0.001) potentiation of pressor effect of tyramine in 14 day treatment model. Heart rate increased in both VS 25 (30 and 60mg/kg) treated rats. After injection of tyramine (2mg/kg) indicating tachycardia compared to moclobemide and cmc control. Subsequent doses showed mild tachycardia. It is concluded that cardiovascular activity of VS 25 (30 mg/kg) may be due to MAO A inhibition as the potentiation of tyramine pressor response by VS 25 was similar to that of moclobemide.
The impact of an interprofessional standardized patient exercise on attitudes toward working in interprofessional teams

Effective interprofessional education engages participants in authentic tasks, settings and roles. Using these guiding principles, an interprofessional standardized patient exercise (ISPE) was developed and implemented for 101 dental, medical, nurse practitioner, pharmacy and physical therapy students. This study describes the ISPE and evaluates its impact on students' attitudes toward working in interprofessional teams. The attitudes toward health care teams (ATHCT) survey was administered pre- and post-ISPE and to a sample of non-participating students. Faculty and students were surveyed post-ISPE about outcomes and satisfaction. Focus groups were conducted with students from each profession. Students' attitudes toward team-based care improved significantly on the team value and team efficiency subscales of the ATHCT. There were significant differences in attitudes toward team-based care by profession. Faculty and student satisfaction with the ISPE was high. These findings contribute to the growing body of literature on efforts to generate positive attitudes toward interprofessional collaboration early in training, which may influence students' ability to be effective members of healthcare teams.
Effects of maize weevils (Coleoptera: Curculionidae) on production of aflatoxin B1 by Aspergillus flavus in stored corn.

Insects play an important role as facilitators of the aflatoxin-producing fungus, Aspergillus flavus Link, in both preharvest and postharvest corn. The current study investigated the role of maize weevils, Sitophilus zeamais Motschulsky, in enhancing aflatoxin B1 content in stored corn. In laboratory experiments, aflatoxin B1 was quantified with an indirect enzyme-linked immunosorbent assay (ELISA) on corn following artificial infestation with adult weevils that had each been topically treated with 100 spores of A. flavus. Corn kernels infested with A. flavus-contaminated weevils had significantly higher levels of aflatoxin B1 than A. flavus-inoculated corn without weevils. The presence of maize weevils resulted in increased kernel moisture content during incubation, and grain moisture was positively correlated with aflatoxin content across treatments receiving spores. Aflatoxin B1 levels were higher in corn treated with fungus-contaminated weevils compared with corn that was mechanically damaged and inoculated with spores, which in turn had more aflatoxin than undamaged corn treated with spores. Aflatoxin B1 content in corn increased with time of weevil exposure from 7 to 21 d, but decreased after 28 d of exposure. Aflatoxin levels in infested corn increased significantly with increased numbers of A. flavus-contaminated weevils. Maize weevils carried spores both internally and externally; however, substantial numbers of spores were intimately associated with the exoskeleton of adult weevils. These findings indicate that maize weevils facilitate the growth of A. flavus and aflatoxin production in corn by increasing surface area susceptible to fungal infection and increasing moisture content as a result of weevil metabolic activity. (ABSTRACT TRUNCATED AT 250 WORDS)
Demonstration of the translocation der(16)t(1;16)(q12;q11.2) in interphase nuclei of ewing tumors

The der(16)t(1;16) has been detected cytogenetically in a number of malignancies including Ewing tumors (ETs). To enable fast and reliable analysis of der(16) chromosomes, we established an interphase cytogenetic approach. By using two DNA probes hybridizing to the heterochromatic portions on the long arms of chromosomes 1 and 16, this technique allows the detection of this chromosomal aberration in nonproliferating cells. Formation of the der(16) leads to partial excess of 1 q material and partial loss of the long arm of chromosome 16. Double‐target fluorescence in situ hybridization (FISH) experiments were performed on cytospin slides of 13 ETs, near‐triploid tumor cells and normal cells to assess whether the FISH technique used permits the discrimination of nuclei harboring this aberration from nuclei without a der(16) chromosome. In five ETs, we found evidence for the presence of one or two der(16)t(1;16) chromosomes both by FISH and by conventional cytogenetics. Tumor cells displayed two signals for intact chromosomes 1, one or two additional fused signals for the der(16) chromosomes, and one signal for the intact chromosome 16. In one case without fused signals, the presence of a der(16) was demonstrated by hybridizing a painting probe for chromosome 16 simultaneously with the paracentromeric probe for chromosome 1. Our results suggest that double‐target FISH on interphase nuclei offers an ideal tool for analyzing tumors prospectively and retrospectively to assess the biological role and the possible prognostic impact of the der(16) in ETs and in other solid tumors. Genes Chromosom Cancer 17:141–150 (1996) © 1996 Wiley‐Liss, Inc.
Higher miR-10 b expression contributes to malignant behaviors in gastric cancer in ex vivo and in vitro

Overexpression of miR-10b was associated with human carcinogenesis and cancer progression, whereas miR-10b expression and functions in gastric cancer remain inclusive and controversial. This study assessed miR10b expression in gastric cancer tissues and cell lines for association with clinicopathological data from patients and then investigated miR-10b overexpression in regulation of tumor cell malignant behaviors in vitro. Levels of miR10b expression was detected using quantitative PCR in eight human gastric cell lines and 70 tissue samples from gastric cancer patients. Expression of miR-10b was induced in gastric cancer and then assessed for changed cell migration and invasion ability using wound healing and Transwell invasion assays. Levels of miR-10b were higher in gastric cancer cell lines than that of normal gastric epithelial cell GES-1 and associated with tumor cell differentiation and lymph node metastasis potential. Moreover, miR-10b expression was also up-regulated in gastric cancer tissues compared to non-tumor tissues, upregulated expression of which was associated with larger tumor size (P = 0.007), tumor location (P = 0.038), tumor cell de-differentiation (P = 0.042), and tumor local invasion depth (P = 0.001). In addition, overexpression of miR-10b using gene transfection technique showed induction of AGS cell migration and invasion capacity. The data from our current study indicated that miR-10b could involve gastric cancer development and progression. Further study will assess whether target of miR-10b can be useful as a novel strategy in control of gastric cancer progression.
RNA as a key fa preventing self-a TAR DNA-bindin

Amyotrophic lateral sclerosis and frontotemporal lobar degeneration are incurable motor neuron diseases associated with muscle weakness, paralysis and respiratory failure. Accumulation of TAR DNA-binding protein 43 (TDP-43) as toxic cytoplasmic inclusions is one of the hallmarks of these pathologies. TDP-43 is an RNAbinding protein responsible for regulatingRNA transcription, splicing, transport and translation. Aggregated TDP43 does not retain its physiological function. Here, we exploit the ability of TDP-43 to bind specific RNA sequences to validate our hypothesis that the native partners of a protein can be used to interfere with its ability to self-assemble into aggregates. We propose that binding of TDP-43 to specific RNA can compete with protein aggregation. This study provides a solid proof of concept to the hypothesis that natural interactions can be exploited to increase protein solubility and could be adopted as a more general rational therapeutic strategy. Crown Copyright © 2019 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Maximum likelihood estimation via the ECM algorithm: A general framework

Two major reasons for the popularity of the EM algorithm are that its maximum step involves only complete-data maximum likelihood estimation, which is often computationally simple, and that its convergence is stable, with each iteration increasing the likelihood. When the associated complete-data maximum likelihood estimation itself is complicated, EM is less attractive because the M-step is computationally unattractive. In many cases, however, complete-data maximum likelihood estimation is relatively simple when conditional on some function of the parameters being estimated