Miracle-dz/UniFAR-FTUs huggingface dataset:
AN ON-LINE MILL LOAD MONITORING SYSTEM BASED ON SHELL VIBRATION SIGNALS

The mill is the major equipment in the mill grinding process.Improving the effectiveness of real time mill load monitoring is of great significance for the optimal control on the mill grinding process.This paper proposed an on-line mill load monitoring system.The functions of the system include: vibration signal measurement using accelerometers mounted directly on the mill shell,system positioning and wireless signal transmission.Based on several experiments in the real industry environment,the results verified that the system meets the actual needs of the production site and operates reliably.
Discovery of SARS-CoV-2 3CLPro Peptidomimetic Inhibitors through the Catalytic Dyad Histidine-Specific Protein–Ligand Interactions

As the etiological agent for the coronavirus disease 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenges the ongoing efforts of vaccine development and drug design. Due to the accumulating cases of breakthrough infections, there are urgent needs for broad-spectrum antiviral medicines. Here, we designed and examined five new tetrapeptidomimetic anti-SARS-CoV-2 inhibitors targeting the 3C-Like protease (3CLPro), which is highly conserved among coronaviruses and essential for viral replications. We significantly improved the efficacy of a ketoamide lead compound based on high-resolution co-crystal structures, all-atom simulations, and binding energy calculations. The inhibitors successfully engaged the catalytic dyad histidine residue (H41) of 3CLPro as designed, and they exhibited nanomolar inhibitory capacity as well as mitigated the viral loads of SARS-CoV-2 in cellular assays. As a widely applicable design principle, our results revealed that the potencies of 3CLPro-specific drug candidates were determined by the interplay between 3CLPro H41 residue and the peptidomimetic inhibitors.
Manager characteristics and early innovation adoption during crises: the case of COVID-19 preventive measures in Danish Eldercare

ABSTRACT Reacting rapidly and adequately in the early stages of a crisis is crucial to effective crisis management. This study analyses the relationship between key first-line manager characteristics, early innovation adoption and crisis scenarios in the context of Danish eldercare during the early stages of the COVID-19 crisis. Our findings show that manager characteristics such as education level, eldercare job tenure and previous similar experience are important to early innovation adoption in crises. The study contributes to the crisis management literature by emphasizing the importance of first-line manager characteristics in effective crisis management.
Cultural ecology: adaptation - retrofitting a concept?

Adaptation was a core concept of twentieth-century cultural ecology. It is having a new life in the context of debates over climate change, particularly as it becomes more significant in public discourse and policy. In this third and final progress report, I identify ways in which geographers and others are currently using the concept of adaptation, tracing both continuities and discontinuities with its earlier heritage. Three differences that warrant attention are the new mitigation/adaptation binary, the deliberate and conscious nature of climate change adaptation, and the fact that the stimuli to which we are adapting are complex assemblages comprising more-than-climate. To ‘retrofit’ the concept for twenty-first-century conditions, we should avoid the limitations of some past uses, and enhance its operation with new techniques and approaches. I identify four threads in recent geographic research that enhance the retrofit: cultural research around climate; emphasis on everyday practices; attention to the contingencies of scale; and more-than-human/ more-than-nature theoretical conceptualizations.
Sleep disturbances, sleep-disordered breathing, and cognitive impairment in older adults: perioperative implications

The mechanisms behind sleep have been studied in the last few decades, illustrating a complex process of sleep-wake cycles regulated by interactions and connections between various regions andnuclei in the brain. Many of these regions are involved in memory and cognitive function. Sleep also changes with increasing age, with observed changes in individuals over 60 years including decreased total sleep duration, decreased slow-wave sleep and rapid eyemovement (REM), increased time awake after sleep onset (WASO), and decreased sleep efficiency. While some of these changes may be physiological, others may be due to neurocognitive or neurodegenerative processes. The impact of sleep disturbances is multifaceted. Poor sleep is associated with reduced cognitive, affective, and physiological responses to stressors, physical diseases across all organ systems, and mood disorders. Mounting evidence also supports a link between sleep disturbances, including poor sleep quality, excessive daytime sleepiness, andboth short (typically<6 hof sleep a night) and long (typically >9 h of sleep a night) sleep duration with cognitive impairment. Furthermore, sleep disturbances, sleep-disordered breathing (SDB), or abnormal respiratory patterns occurring during sleep also increase the risk of cognitive decline in older adults (age over 60 y), and may also increase the risk of various postoperative complications including postoperative delirium (POD). The objective of this review is to examine the current evidence regarding the effect of and proposed mechanisms behind sleep disturbances and SDB [with a focus on obstructive sleep apnea (OSA)], with cognitive decline and impairment. The possible association of sleep disturbances and SDB with postoperative complications will be discussed, along with the potential utility of continuous positive airway pressure (CPAP) therapy and sleep hygiene in preventing these complications.
A Simple Method for Breast De-epithelialization: The Monobloc Method

The process of de-epithelialization in reduction mammoplasty surgery increases the operation time. In addition, longer operation times are more apt to cause fatigue for the surgeon. Furthermore, it is always preferable to use the time in the operating theater as effectively as possible. Although the gold standard when performing de-epithelialization is with the use of a scalpel, there are some initiatives to accelerate the speed of the operation and decrease the blood loss during the operation.1-5 While the use of novel products has the potential to speed up the operation, their use may be accompanied by unexpected complications.
Generalized Energy Index for Comprehensively Evaluating the Dynamic Characteristics of Vehicle/Track System

Track quality index(TQI) is used to evaluate the irregularity of track district,but it does not have the ability of reflecting the fact that different vehicle running on the same track has different dynamic characteristics.Generalized energy index(GEI) is presented to evaluate the dynamic characteristics of vehicle/track system by borrowing the idea from the method of energy concentration ratio,and energy weight coefficients are introduced to characterize the inherent property that the irregularity with different wavelength has different effect on the dynamic response of the vehicle/track system.Under the condition that the energy weight coefficients are equal,Parseval theorem is applied to prove that GEI can be simplified to TQI,which is also verified through field data of track irregularity.The amplitude curve of the transfer function between the track irregularity and the vehicle response is used to calculate the coefficients by adding the constraint on them that the sum of them is equal to 1.GEI is applied to evaluate rail wavy irregularity,and the numerical results show that GEI is better than TQI in the evaluation of rail wavy irregularity.The rationality of the evaluation result can be checked through whether the vehicle buffets or not.
The Type Fragmentation Patterns Confirmed Acetaminophen By Using Liquid Chromatography-Mass Spectroscopy (LCMS) From Herbal Medicine (Jamu)

Abstract: The Jamu or herbal medicine were adulterated with chemical drugs in the last twenty years. One of the chemical drugs that are commonly added to herbal medicine is acetaminophen. Acetaminophen is generally considered an analgesic-antipyretic drug. The research aims to identify the content of paracetamol and its amount added to the jamu. This study consisted of 6 jamu or herbal medicine samples with different brands. The TLC method conducted the qualitative analysis using the mobile phase n-hexane: ethyl acetate (1:1). Three positive samples containing acetaminophen were obtained: D, E, and F. The three positive samples containing acetaminophen were calculated using the LCMS method. Quantitative analysis was conducted with LCMS using a reversed-phase with a mobile phase of acetonitrile: water (15%>: 85%> v/v) at a flow rate of 0.2 mL/min and an injection volume of 5 µL, it was obtained the levels of acetaminophen in sample D as much as 0.16 g/2 g of sample, in sample E of 0.63 g/7 g of sample, and sample F of 0.56 g/7 g of sample. Although the acetaminophen content in herbal medicine is relatively small, according to the Regulation of the Minister of Health of Indonesia No. 007 of 2012, traditional medicine or herbal medicine should not contain synthetic chemicals.Abstrak: Dalam dua puluh tahun terakhir, banyak jamu yang dipalsukan dengan obat-obatan kimia. Salah satu obat kimia yang biasa ditambahkan pada jamu adalah asetaminofen. Acetaminophen umumnya dianggap sebagai obat analgesik-antipiretik. Penelitian ini bertujuan untuk mengetahui kandungan parasetamol dan jumlah yang ditambahkan pada jamu. Sampel penelitian ini terdiri dari 6 sampel jamu dengan merek yang berbeda. Analisis kualitatif dilakukan dengan metode KLT menggunakan fase gerak n-heksana: etil asetat (1:1). Diperoleh tiga sampel positif mengandung asetaminofen, yaitu sampel D, E, dan F. Tiga sampel positif mengandung asetaminofen dihitung menggunakan metode LCMS. Analisis kuantitatif dilakukan dengan LCMS menggunakan fase terbalik dengan fase gerak asetonitril: air (15%>:85%> v/v) pada laju alir 0,2 mL/menit dan volume injeksi 5 µL. Diperoleh kadar asetaminofen pada sampel D sebanyak 0,16 g/2 g sampel, pada sampel E sebesar 0,63 g/7 g sampel, dan pada sampel F sebesar 0,56 g/7 g sampel. Meskipun kandungan asetaminofen dalam jamu relatif sedikit, namun menurut Peraturan Menteri Kesehatan RI No. 007 Tahun 2012, obat tradisional atau jamu tidak boleh mengandung bahan kimia sintetik.
SDCCZPES an expert system used in operation scheduling and management of hydropower station

This paper describes the meaning of developing operation scheduling expert system,its structure,specialties and merits.Here is also given a brief introduction to the ruler model method,the principle and process of interference machine,knowledge,database manager and man machine interface.A tentative plan of perfecting the system has been put forward while it is in use at the hydropower station.
Effects of Experimental Design, Genetic Architecture and Threshold on Power and False Positive Rate of Genome-Wide Association Studies

Genome-Wide Association Studies are an important tool for identifying genetic markers associated with a trait, but it has been plagued by the multiple testing problem, which necessitates a multiple testing correction method. While many multiple testing methods have been suggested, e.g. Bonferroni and Benjamini-Hochberg’s False Discovery Rate, the quality of the adjusted threshold based on these methods is not as well investigated. The aim of this study was to evaluate the balance between power and false positive rate of a Genome-Wide Association Studies experiment with Bonferroni and Benjamini-Hochberg’s False Discovery Rate multiple testing correction methods and to test the effects of various experimental design and genetic architecture parameters on this balance. Our results suggest that when the markers are independent the threshold from Benjamini-Hochberg’s False Discovery Rate provides a better balance between power and false positive rate in an experiment. However, with correlations between markers the threshold of Benjamini-Hochberg’s False Discovery Rate becomes too lenient with an excessive number of false positives. Experimental design parameters such as sample size and number of markers used, as well as genetic architecture of a trait affect the balance between power and false positive rate. This experiment provided guidance in selecting an appropriate experimental design and multiple testing correction method when conducting an experiment.
High efficacy of layered controls for reducing exposure to airborne pathogens.

To optimize strategies for curbing the transmission of airborne pathogens, the efficacy of three key controls-face masks, ventilation, and physical distancing-must be well understood. In this study, we used the Quadrature-based model of Respiratory Aerosol and Droplets to quantify the reduction in exposure to airborne pathogens from various combinations of controls. For each combination of controls, we simulated thousands of scenarios that represent the tremendous variability in factors governing airborne transmission and the efficacy of mitigation strategies. While the efficacy of any individual control was highly variable among scenarios, combining universal mask-wearing with distancing of 1 m or more reduced the median exposure by more than 99% relative to a close, unmasked conversation, with further reductions if ventilation is also enhanced. The large reductions in exposure to airborne pathogens translated to large reductions in the risk of initial infection in a new host. These findings suggest that layering controls is highly effective for reducing transmission of airborne pathogens and will be critical for curbing outbreaks of novel viruses in the future.
A calculation method for internal force of prestressed anchor-rope and frame beam-on-foundation on high rock slope

According to the mechanical characteristic of high rock slope, calculation of internal force of prestressed anchor rope frame beam on foundation should be respectively completed on pulling anchor rope status and long term working status on high rock slope. Frame beam on foundation can be split into several single beams for the purpose of calculation. The single beams can be analyzed on the basis of Winkler model on the pulling anchor rope status. However, The single beams may be analyzed on the basis of continuous beam model on the long term working status. The calculation procedure is provided by a practical project in this paper.
NON-CONTACT SURFACE WAVE MEASUREMENTS USING A MICROPHONE

Pavements are typically constructed using several layers of materials, and their durability depends on the quality of these strata. It is therefore very valuable to be able to determine the properties of the layers non-destructively. Accelerometers can be used as receivers in surface wave testing of pavements, but require good seismic coupling to the surface. We present experiments using a nondirectional audio microphone as a non-contact receiver. Leaky air-coupled surface waves are measured and processed using the Multichannel Analysis of Surface Waves (MASW) technique. Results show that leaky surface waves can be accurately measured using an ordinary audio microphone. This opens up the possibility for fast on-the-fly surface wave testing of pavements. We present the method along with a case study where the thickness and the stiffness of a concrete slab are evaluated from a data set acquired using a microphone as a non-contact receiver.
Facebook Messenger as an Educational Platform to Scaffold Deaf Students’ Conceptual Understanding in Environmental Science Subject: A Single Group Quasi-Experimental Study

The advent of technology proliferates the evolution of social media that creates a massive breakthrough in different aspects of life, especially in education. Teachers play a crucial role as they adapt to the new era of an educational system where students with special needs are mainstreamed in the regular learning environment. Student’s success in learning is attributed to teachers' effective techniques, methods, and approaches to deliver quality and meaningful learning to diverse students regardless of religion, ethnic groups, race, culture, and disabilities. This context inspired the author to investigate the effectiveness of Facebook Messenger as an educational platform in teaching to scaffold deaf students’ conceptual understanding in environmental science subject through a quasi-experiment to a single group composed of four (N=4) deaf college students in one selected State College of the Higher Education Institutions (HEIs) in Northern Negros Philippines. The findings revealed that deaf students had a very low conceptual understanding of the subject in the pre-test, however, manifested very high after the intervention (post-test). Moreover, results show that there was no significant difference in the level of the participants’ conceptual understanding between and among gender groups, however, the difference was significant in the pre-test and post-test gained scores. Furthermore, Facebook Messenger has been proven effective and thereby recommended to maximize its potential as an educational tool in teaching to scaffold deaf students’ conceptual understanding of science fields and other disciplines.
Residents’ attitudes towards nightlife supply: A comparison of Ibiza (Spain) and Punta del Este (Uruguay)

In coastal tourist destinations, there is nightlife, in addition to daytime leisure. For tourism development, it is of great relevance to take into account the resident population and their attitudes. In this paper, a comparison is made between Ibiza (Spain) and Punta del Este (Uruguay) in relation to the residents’ attitudes towards nightlife. Specifically, the comparison is made by a descending cluster analysis, generating four groups of residents according to their attitudes (Enthusiasts, Moderates, Critics, and Negatives), and the distribution of these groups in the two regions is then compared. The most notable result is that the degree of acceptance of nightlife is low in both cases, possibly due to the problems attributed to it, but the score is slightly higher in the case of Punta del Este. In addition, the profile of those opposed to nightlife is different: In Ibiza, Critics predominate, with a generally contrary response, but recognizing positive elements, whilst in Punta del Este, Negatives predominate, with systematically negative responses to all items.
Peaceful Entry: Entrepreneurship Dynamics during Colombia's Peace Agreement

While there is a large literature on how conflict affects entrepreneurship and investment, little is known about how the end of a conflict affects businesses and firms’ creation. The direction of the effect is not obvious as conflicts bequest poverty and inequality –reducing the returns of investment–and the territorial vacuum of power inherent to most post-conflict situations may trigger new violent cycles. Studying Colombia’s recent peace agreement and using a difference-in-differences empirical strategy, we document that dynamics of entrepreneurship in traditionally violent areas closely mapped the politics that surrounded the peace agreement. When the agreement was imminent after a 5-decade conflict and violence had plummeted, local investors from all economic sectors established new firms and created jobs. Instead, when the agreement was rejected by a tiny vote margin in a referendum and the party that promoted this rejection raised to power, the rate of firms’ creation rapidly reversed.
Diurnal Variability of Platelet Aggregation in Patients with Myocardial Infarction Treated with Prasugrel and Ticagrelor

Background: Contemporary antiplatelet treatment in acute myocardial infarction (AMI) is based on one of two P2Y12 receptor inhibitors, prasugrel or ticagrelor. The aim of this study was to compare diurnal variability of platelet reactivity between patients receiving prasugrel and ticagrelor during the initial phase of maintenance treatment after AMI. Methods: It was a prospective, two-center, pharmacodynamic, observational study. Blood for platelet testing was sampled at four time points on day four after AMI (8:00, 12:00, 16:00, 20:00). Diurnal variability of platelet reactivity was expressed as a coefficient of variation (CV) of the above-mentioned measurements. Results: 73 invasively-treated patients were enrolled (ticagrelor: n = 47, prasugrel: n = 26). CV was greater in patients treated with ticagrelor compared with prasugrel according to a VASP assay (47.8 [31.6–64.6]% vs. 21.3 [12.9–25.5]%, p < 0.001), while no statistical differences were detected when the CVs of platelet aggregation according to Multiplate were compared between ticagrelor- and prasugrel-treated patients. Ticagrelor-treated patients showed more pronounced platelet inhibition than prasugrel at 16:00 and 20:00 (VASP16:00: 20.6 ± 15.0 vs. 24.9 ± 12.8 PRI, p = 0.049; VASP20:00: 18.6 ± 17.7 vs. 26.0 ± 11.7 PRI, p = 0.002). Conclusions: Ticagrelor shows greater diurnal variability in platelet aggregation than prasugrel during the initial maintenance phase of AMI treatment, and this is due to the continuous increase of platelet inhibition after the morning maintenance dose. Both drugs provide an adequate antiplatelet effect early after AMI. Evaluation of the clinical significance of these findings warrants further investigation.