Equilibrium in the System of Glauconite – Aqueous Solution of Cefepime Hydrochloride

The patterns of immobilization of cefepime hydrochloride on glauconite at a temperature of 295 K are established. The isotherm of sorption of cefepime hydrochloride from dilute solutions is described using the Langmuir theory. The values of the maximum capacity of the monolayer and the coefficient of the sorption equilibrium for cefepime hydrochloride are calculated. It is revealed that the monolayer binding of the antibiotic to glauconite is the result of an equivalent exchange with the extra-frame cations of the sorbent. The polymolecular nature of the sorption may be due to the formation of cefepime hydrochloride associates due to hydrogen bonds. REFERENCES Кevadiya Bravesh D. , Ghanshyam V. Joshi, Hasmukh A. Patel, et al. Montmorillonite-alginate nanocomposites as a drug delivery system: intercalation and in vitro release of vitamin B1 and vitamin B6. Journal of Biomaterials Aplications, 2010, v. 25(2), pp. 161-177. DOI: https://doi.org/10.1177/0885328209344003 Farias T. , Rabdel Ruiz-Salvador A. , Lya Velazco, et al. Preparation of natural zeolitic supports for potential biomedical applications. Materials Chemistry and Physics, 2009, v. 118, pp. 322–328. doi: https://doi.org/10.1016/j.matchemphys. 2009.07. 054 Chernova R.K. , Venig S.B. , Naumova G.N. , et al. Sorption of tetracycline and its degradation products by glauconite. Scientific almanac, 2015, 7, pp. 930-934. doi: https://doi.org/0.17117/na.2015. 07.930 Vlasova N.N. Interaction of highly dispersed silica with some medicinal substances. Surface, 2016, v. 8(23), pp. 236-247. DOI: https://doi.org/10.15407/surface.2016. 08.236 Stavinskaya O.N. , Laguta I.V. The properties of silica-gelatin composites. Russian Journal of Physical Chemistry A, 2010, v. 84(6), pp. 1045-1048. doi: https://doi.org/10.1134/s0036024410060270 Fiziko-khimicheskiye i mediko-biologicheskiye svoystva prirodnykh zeolitov [Physicochemical and biomedical properties of natural zeolites] / Ed. by Z.V. Belousova. Novosibirsk, Izd-vo un-ta geologii i geofiziki Publ. , 1990, 70 p. (in Russ.) Breck D. W. Zeolite molecular seves: Structure, Chemistry and Use. Wiley—Interscience, New York, 1974, 771 p. Egorov N.S. Osnovy ucheniya ob antibiotikakh [Fundamentals of the doctrine of antibiotics]. Moscow, Nauka Publ. , 2004, 528 p. (in Russ.) Yakovlev P.V. Ciprofloxacin in the treatment and prophylaxis of surgikal infections. Antibiotiki i khimioterapiya, 1999, v. 44(7), pp. 32-37. (in Russ.) Zhabin A.V. , Savko A.D. Glaukonity Voronezhskoy anteklizy. Ocherki po regionalnoy geologii [Glauconites of the Voronezh anteclise. Essays on regional Ggeology]. Saratov, Nauka Publ. , 2008, pp. 48-56. (in Russ.) Novikova L.A. , Belchinskay L.I. , Krupskaya V.V. , et al. Effect of acid and alkaline treatment on physical and chemical properties of natural glauconite surface. Sorption and Chromatographic Processes, 2015, v. 15(5), pp. 730-740. Available at: https://doi.org/10.17308/sorpchrom.2015. 15/327 (accessed 23.10.2019) (in Russ.) Polyanskiy N.G. Gorbunov V.G. Polyanskaya N.L. Research methods of ion exchangers. Moscow, Khimiya Publ. , 1976, 208 p. (in Russ.) Nakanisi K. Infrared spectroscopy and structure of organic compounds. Moscow, Mir Publ. , 1987, 220 p. (in Russ.) Bekker Yu. Spektroskopiya [Spectroscopy]. Moscow, Tekhnosfera Publ. , 2009, 528 p. (in Russ.) Sing K.S. W. , Everett D.H. , Haul R.A. W. Reporting physisorption data for gas/solid systems with special reference to the determination of surface area and porosity. Pure and Applied Chemistry, 1985, v. 57(4), pp. 603-619. doi: https://doi.org/10.1351/pac198557040603 Kotova D.L. , Fam Tkhi Gam, Krysanova T.A. , et al. Description of pyridoxine hydrochloride sorption isotherm on clinoptilolite tuff. Sorption and Chromatographic Processes, 2014, v. 14(4), pp. 572-577. Available at: http:// www.sorpchrom. vsu.ru/articles /20140404.pdf (accessed 23.10.2019) (in Russ.) Langmuir I. The Constitution and fundamental properties of solids and liquids. Am. Chem. Soc. , 1917, v. 39(9), pp. 1848-1906. doi: https://doi.org/10.1021/ja02254a006 Freundlich H.M. F. Over the adsorption in solution. Phys. Chem., 1906, v. 57, pp. 385-447. Redlich O.A. , Peterson D.L. Useful adsorption isotherm. Phys. Chem., 1959, v. 63(6), pp. 1024-1025. doi: https://doi.org/10.1021/j150576a611 Pyul'man B. Intermolecular interaction: from diatomic molecules to biopolymers, Moscow, Мir Publ. , 1981, 592 p. (in Russ.)