Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimizing Adaptive Therapy Based on the Reachability to Tumor Resistant Subpopulation

Simple Summary The intra-competition among tumor subpopulations is a promising target to modify and control the outgrowth of the resistant subpopulation. Adaptive therapy lives up to this principle well, but the gain of tumors with an aggressive resistant subpopulation is not superior to maximum tolerated dose therapy (MTD). How to integrate these two therapies to maximize the outcome? According to the model and system reachability, the ‘restore index’ is proposed to evaluate the timing of the transition from the treatment cycle of adaptive therapy to high-frequency administration, and to juggle the benefits of intra-competition and killing of the sensitive subpopulation. Based on the simulation and animal experiment, the effectiveness of this method in treating tumors with an aggressive resistant subpopulation has been confirmed. Abstract Adaptive therapy exploits the self-organization of tumor cells to delay the outgrowth of resistant subpopulations successfully. When the tumor has aggressive resistant subpopulations, the outcome of adaptive therapy was not superior to maximum tolerated dose therapy (MTD). To explore methods to improve the adaptive therapy’s performance of this case, the tumor system was constructed by osimertinib-sensitive and resistant cell lines and illustrated by the Lotka-Volterra model in this study. Restore index proposed to assess the system reachability can predict the duration of each treatment cycle. Then the threshold of the restore index was estimated to evaluate the timing of interrupting the treatment cycle and switching to high-frequency administration. The introduced reachability-based adaptive therapy and classic adaptive therapy were compared through simulation and animal experiments. The results suggested that reachability-based adaptive therapy showed advantages when the tumor has an aggressive resistant subpopulation. This study provides a feasible method for evaluating whether to continue the adaptive therapy treatment cycle or switch to high-frequency administration. This method improves the gain of adaptive therapy by taking into account the benefits of tumor intra-competition and the tumor control of killing sensitive subpopulation.
Double Integral of the Product of the Exponential of an Exponential Function and a Polynomial Expressed in Terms of the Lerch Function

In this work, the authors use their contour integral method to derive an application of the Fourier integral theorem given by ∫−∞∞∫−∞∞emx−my−ex−ey+y(log(a)+x−y)kdxdy in terms of the Lerch function. This integral formula is then used to derive closed solutions in terms of fundamental constants and special functions. Almost all Lerch functions have an asymmetrical zero distribution. There are some useful results relating double integrals of certain kinds of functions to ordinary integrals for which we know no general reference. Thus, a table of integral pairs is given for interested readers. All of the results in this work are new.
The Oxford Handbook of Global Studies

This handbook provides an overview of the emerging field of global studies. Since the end of the Cold War, globalization has been reshaping the modern world, and an array of new scholarship has risen to make sense of it in its various transnational manifestations—including economic, social, cultural, ideological, technological, environmental, and in new communications. The chapters discuss various aspects in the field through a broad range of approaches. Several chapters focus on the emergence of the field and its historical antecedents. Other chapters explore analytic and conceptual approaches to teaching and research in global studies. The largest section deals with the subject matter of global studies—challenges from diasporas and pandemics to the global city and the emergence of a transnational capitalist class. The final two sections feature chapters that take a critical view of globalization from diverse perspectives and essays on global citizenship—the ideas and institutions that guide an emerging global civil society. This handbook focuses on global studies more than on the phenomenon of globalization itself, although the various aspects of globalization are central to understanding how the field is currently being shaped.
Decomposing the factors influencing household debt: the case of China

ABSTRACT This study discusses the issue of household debt in China based on the data of China household finance survey completed in 2015. The quantile regression model is adopted as the key research method, and the conclusions are derived are as follows. The increase in household debt in China is significantly correlated with several financial factors, including household assets and income, as well as the socioeconomic factors of education, age and working unit, in addition to senses of security and happiness. The assets of highly indebted households influence their debt in a positive way; the influence of income on household debt decreases as the quantile increases; the householder age has a negative effect across all household quantiles, and the debt holdings are less at older ages. The influence of household educational background dramatically increases from negative to positive following the indebtedness level, suggesting that enormous debt burdens may be generated from the cross effect of disadvantages in income and educational background. By decomposing the results of the quantile regression estimations, the evidence suggests that sufficient financial knowledge is essential in avoiding the financial distress from household debt.
Effect of Target Size, Location, and Input Method on Interaction in Immersive Virtual Reality

Although new virtual reality (VR) devices and their contents are actively being released, there are still not enough studies to prepare its interface/interaction standard. In this study, it was investigated whether specific interaction factors influenced task performance and the degree of virtual reality sickness when performing pointing tasks in immersive virtual reality. A smartphone-based VR device was used, and twenty-five targets were placed in a 5 × 5 layout on the VR experimental area that extended to a range similar to the human viewing angle. Task completion time (TCT) was significantly affected by target selection method (p < 0.001) and target size (p < 0.001), whereas the error rate (ER) significantly differed for the target selection method (p < 0.001) and not for the target size (p = 0.057). Target location was observed to be a factor affecting TCT (p < 0.001), but it did not affect the ER (p = 0.876). VR sickness was more severe when the target size was smaller. Gaze selection was found to be more efficient when accuracy is demanded, and manual selection is more efficient for quick selection. Moreover, applying these experimental data to Fitts’ Law showed that the movement time was found to be less affected by the device when using the gaze-selection method. Virtual reality provides a three-dimensional visual environment, but a one-dimensional formula can sufficiently predict the movement time. The result of this study is expected to be a reference for preparing interface/interaction design standards for virtual reality.
Entrepreneurship research (2000-2014) in the top six Brazilian journals of administration: gaps and directions

Abstract This article presents a systematic review of entrepreneurship research published in the Top six Brazilian Journals of Administration (TBJA) - Revista de Administração de Empresas, Revista de Administração, Revista de Administração Contemporânea, Brazilian Journal of Public Administration, Brazilian Administration Review, and Organização & Sociedade, during the period 2000-2014. It aims to identify gaps and directions for Brazilian entrepreneurship research to become a relevant area within the field of Administration. The results highlighted the following gaps: (i) few entrepreneurship publications within the TBJA; (ii) impact of the TBJA production is low compared to international journals focused exclusively on entrepreneurship; (iii) prevalence of qualitative methodological approaches. As directions, the results show: (i) to give preference to empirical studies carried out by rigorous methodologies (longitudinal, secondary data and experimental design); (ii) realization of empirical studies extending the theoretical basis of the existing literature; (iii) establishment of entrepreneurship research lines in Master/Doctoral Programs. This article contributes theoretically by identifying research gaps and directions, and by conducting a critical analysis of the entrepreneurship research and practice to give a perspective to researchers and first time authors to produce high impact papers.
Reliability-based optimization of water distribution networks

The water distribution system serves as a basic necessity for society. Due to its large size and involvement of various components, it is one of the most expensive civil infrastructures and thus demands optimization. Much work has been done for reducing the distribution system cost. However, with only one objective, the obtained solutions may not be practical to implement. Thus, improving cost along with the efficiency of the network is the demand of the hour. The present work introduces a unique parameter-less methodology for generating Pareto fronts without involving the concept of non-dominance. The methodology incorporates the Jaya optimization model for a bi-objective problem, one being the reduction in network cost and the other is improving the reliability index of the network. The efficiency of the proposed work is analyzed for three different benchmark problems. The Jaya technique is found to be very efficient and fast when compared with the other evolutionary technique applied for the same networks. The parameter-less nature of the Jaya technique smoothens the process to a very large extent as no synchronization of algorithm parameters is required.
Will COVID-19 Threaten the Survival of the Airline Industry?

The pandemic causes social distancing and lockdown, which impedes consumer confidence and contracts the economy. Hence, this study analyzes the corona (COVID-19) impact on the airline industry revenues (ALR) and forecast by the vector autoregression (VAR) method. The results indicate that gross domestic product (GDP) and air cargo are the best predictors of ALR. The forecasting outcomes explore if ALR will decline and expect to back to pre-COVID-19 in 2023. Our results resemble both the V-shaped and U-shaped, which suggests slow gradual recovery with longer lockdown and border disclosure. The government can restore confidence building by providing economic stimulus packages and can encourage the airline to return to travel. Furthermore, softening the passenger rules concerning the refund of unflown ticket, reducing taxes, and reducing overflight taxes, all reduce the costs. Similarly, the mutually recognized global standards are crucial for effective execution, and any temporary measures taken by the government should have a clear exit strategy. The study major limitation includes the lack of relevant research and data availability.
Some study results of color changes depending on Mongolian environmental condition

We started a color experiment, which is tried to obtain the method studying quality of colorants and color fading of objects. This long-term color measurement can be used to determine how the colorants change by environmental influence, and to develop the methodology for such analysis will predict the initial object color. This will allow the cultural heritage to be restored by its original color, as well as to determine which colorants have the least changing and the most durable. Therefore, in this study we prepared a measurement object to analyse color fading, performed long-term and short-term measurements weekly for five months. Processing of the measurement results shows that most of the pigments have faded and most of the dye were stable, but the white dye changed the most. It is possible that the change depends on the absorption of the color spectrum. In the next research we have increased the measurement objects, so the data analysis will be more precise, and the aim is to forecast the initial color of the object using a machine learning approach based on regression analysis by more color measurement values.
New Therapeutic Strategy for Overcoming Multidrug Resistance in Cancer Cells with Pyrazolo[3,4-d]pyrimidine Tyrosine Kinase Inhibitors

Simple Summary P-glycoprotein (P-gp) is an ATP-binding cassette transporter whose overexpression in cancer cells is one of the main causes of multidrug resistance (MDR). Tyrosine kinase inhibitors (TKIs) have been reported to interact with ABC transporters and in some cases, increase the susceptibility of cancer cells to chemotherapy. We investigated the potential of novel TKI pyrazolo[3,4-d] pyrimidines and their prodrugs to inhibit P-gp in two MDR cancer cell lines with P-gp overexpression. The tested compounds were able to suppress P-gp by inhibiting its ATPase activity. Interestingly, prodrugs displayed a stronger potential to modulate P-gp and showed higher interaction energies in the docking simulations compared to their parent drugs. Furthermore, prodrugs showed significant potential to inhibit P-gp activity even in prolonged treatment and therefore to enhance the efficacy of doxorubicin and paclitaxel in MDR cancer cells. All of these characteristics imply that the new TKIs could be considered a valuable strategy for combating resistant cancers, especially in combination with other chemotherapeutics. Abstract Tyrosine kinase inhibitors (TKIs) often interact with the multidrug resistant (MDR) phenotype of cancer cells. In some cases, TKIs increase the susceptibility of MDR cancer cells to chemotherapy. As the overexpression of membrane transporter P-glycoprotein (P-gp) is the most common alteration in MDR cancer cells, we investigated the effects of TKI pyrazolo[3,4-d]pyrimidines on P-gp inhibition in two cellular models comprising sensitive and corresponding MDR cancer cells (human non-small cell lung carcinoma and colorectal adenocarcinoma). Tested TKIs showed collateral sensitivity by inducing stronger inhibition of MDR cancer cell line viability. Moreover, TKIs directly interacted with P-gp and inhibited its ATPase activity. Their potential P-gp binding site was proposed by molecular docking simulations. TKIs reversed resistance to doxorubicin and paclitaxel in a concentration-dependent manner. The expression studies excluded the indirect effect of TKIs on P-gp through regulation of its expression. A kinetics study showed that TKIs decreased P-gp activity and this effect was sustained for seven days in both MDR models. Therefore, pyrazolo[3,4-d]pyrimidines with potential for reversing P-gp-mediated MDR even in prolonged treatments can be considered a new therapeutic strategy for overcoming cancer MDR.
Green Synthesized Silver Nanoparticles Using Tridax Procumbens for Topical Application: Excision Wound Model and Histopathological Studies

The objective of this study was to synthesize silver nanoparticles from the leaves of Tridax procumbens and develop its topical gels using chitosan to investigate the wound healing efficacy concomitant with the histopathological study. Green synthesized silver nanoparticles (AgNPs) were prepared by reacting silver nitrate (0.3 M) with leaf extract and characterized by particle analysis, FTIR, XRD, SEM, BET, and TGA. The results revealed formed AgNPs were nano-sized (138 ± 2.1 nm), monodispersed (PDI: 0.460 ± 0.3), inter-particle repulsion (zeta: −20.4 ± 5.20 mV), stabilized, crystalline and, spherical with size ranging from 80–100 nm as per SEM micro photos. The BET analysis of AgNPs presents the surface area (12.861 m2/g), pore volume (0.037 cc/g), and pore radius (24.50 nm). TGA results show a loss of 13.39% up to 300 °C. The topical formulation was developed by loading AgNPs in chitosan-based gels, evaluated by pH, thermal cycling, centrifugal, and spreadability tests. AgNPs chitosan gels results showed skin compatibility, higher stability, and spreading ability. The maximum antibacterial zone of inhibition was found to be 25 ± 0.98 mm for bacillus subtitles and 30 ± 1.99 mm for Klebsiella pneumoniae, respectively. Nanosilver-containing gel also showed excellent compatibility with erythrocytes. Excision wound model was used to assess the wound healing property of the developed AgNP gels, the results of which indicated a significantly progressive healing process in test-group of animals treated with chitosan-based gels containing AgNPs. A histopathological study further confirmed the almost normal skin structure of treated animal tissue compared to standard and negative control. Thus, green synthesized AgNPs loaded chitosan-based topical gel can potentially be used for wound healing application.
Religious Coping and Life Satisfaction during the COVID-19 Pandemic among Polish Catholics. The Mediating Effect of Coronavirus Anxiety

Recent data have indicated that people may have experienced fear during the COVID-19 pandemic. This study aims to deepen our understanding of the relationship between religious coping and life satisfaction by analysing the indirect effects of fear of COVID-19. Methods: This study included 365 people (75% women) aged 18–78 years. The procedure consisted of completing questionnaires to measure religious coping, COVID-19 anxiety, satisfaction with life, and satisfaction with social support. Results: Structural equation modelling showed that positive religious coping was related to greater life satisfaction and greater satisfaction with social support during the pandemic. Moreover, fear of COVID-19 mediated the relationship between negative religious coping and life satisfaction and social support satisfaction. Conclusions: The data suggest a need for practitioners to focus on interventions that enhance positive religious coping to improve life satisfaction during the spread of infectious diseases.
Reproductive, Obstetric and Neonatal Outcomes in Women with Congenital Uterine Anomalies: A Systematic Review and Meta-Analysis

Congenital uterine anomalies (CUA) may influence reproductive performance, resulting in adverse pregnancy associated complications. This study aimed to assess the association of CUA subtypes with reproductive, obstetric, and perinatal outcomes. We performed a systematic search of the MEDLINE, EMBASE, and Cochrane libraries for studies comparing pregnancy outcomes between women with CUA and those with a normal uterus. The random effects model was used to estimate the odds ratios (ORs) with a 95% confidence interval (CI). Women with CUA had a lower rate of live births (OR 0.47; 95% CI 0.33–0.69), and a higher rate of first trimester miscarriage (OR, 1.79; 95% CI 1.34–2.4), second trimester miscarriage (OR 2.92; 95% CI 1.35–6.32), preterm birth (OR 2.98; 95% CI 2.43–3.65), malpresentation (OR 9.1; 95% CI 5.88–14.08), cesarean section (OR 2.87; 95% CI 1.56–5.26), and placental abruption (OR 3.12; 95% CI 1.58–6.18). Women with canalization defects appear to have the poorest reproductive performance during early pregnancy. However, unification defects were associated with obstetric and neonatal outcomes throughout the course of pregnancy. It may be beneficial for clinicians to advise on potential complications that may be increased depending on the type and severity of CUA.
The role of collaboration in reducing quality variability in Brazilian breweries

Abstract This paper aims to analyse how small-scale breweries undertake vertical and horizontal collaborations to manage their quality performance (when measured by reducing quality variabilities). While vertical collaborations are overemphasised, horizontal and simultaneous collaboration efforts have been understudied. Our contribution lies in proposing an interplay of vertical and horizontal collaborations through information sharing, joint decision-making, and knowledge exchange with intra- and inter-supply chain partners to address quality variability issues. We draw attention to supply chain relationships being predominantly informal, which contribute strongly towards accessing external sources of knowledge. Additionally, such collaborative efforts have led companies to achieve mutual gains in their relationships. Finally, a framework is presented that consolidates the supply chain actors, collaboration types, socialisation mechanisms, and relationship types.
Musical activities for enhancing number concepts in preschool children

A concept is the basic unit of all types of learning. Young children generally form concepts through the use of senses. Number concept is defined by McIntosh et al. (1992), as a person’s general understanding of numbers and operations. Research studies suggest that children construct basic number and arithmetic concepts gradually from experiences that involve numbers and difficulties in counting might hinder in mathematical progress (Baroody and Coslick, 1998). Therefore, attention should be given to assess and understand the number concepts formed during preschool age. Music is considered to play an important role in stimulating young children in learning. Hetland (2000) described that using songs and different music components can help in teaching numbers because of the high association between music and spatial-temporal reasoning skills. The study was carried out on twenty four numbers of pre-school children belonging to the age of 3- 4 years, selected through purposive sampling method. Pre and post-intervention design was used to assess the influence of musical activities on the development of number concepts in children. The number concepts were assessed in the categories of Number sense, Number representation and Number relation based on the principles of counting proposed by Gelman and Galistell (1978). It was found from the study that most children could name numbers but the concept of cardinality was not attained by many of the children. Findings revealed that children improved in all the areas of number concepts after the musical intervention. However, it was also observed that all the concepts are not mastered at the same time by all the children.
Reactivation of Non‐Optimally Orientated Faults Due to Glacially Induced Stresses

The deformation due to an ice load is accompanied by displacement and stress changes. These stress changes are known to have created large‐magnitude earthquakes along pre‐existing faults during and after deglaciation of the Late Quaternary ice sheets. However, these so‐called glacially induced faults have been found to be not optimally orientated in their respective regional stress regime. Here, we analyzed the potential of non‐optimally orientated fault reactivation within a glacially induced stress field as well as changes of the stress regimes due to these additional stresses. A finite element model is used to estimate glacially induced stresses, which are then combined with background stress magnitudes. Non‐optimally orientated faults can be reactivated by glacially induced stresses within thrust‐, strike‐slip‐, and normal‐faulting stress regimes, but depending on their location with respect to the ice sheet and their orientation within the regional stress field. While faults with large variations of dip and strike outside of the ice sheet are prone to reactivation when the background stress field is a normal‐ or strike‐slip‐faulting stress regime, faults within a thrust‐faulting stress regime can also be reactivated within the ice margin during and after the deglaciation. Outside the ice margin, instabilities in a thrust‐faulting stress regime develop along the intermediate principal stress axis. Stress regime changes can occur for all background stress states. Finally, we find that certain conditions in a strike‐slip‐faulting stress regime can also explain the observed glacially induced thrust faults in Northern Europe.