Miracle-dz/UniFAR-FTUs huggingface dataset:
Catel–Manzke syndrome without Manzke dysostosis

Catel–Manzke syndrome is characterized by hand anomalies, Robin sequence, cardiac defects, joint hyperextensibility, and characteristic facial features. Approximately 40 patients with Catel–Manzke have been reported, all with the pathognomonic bilateral or unilateral hyperphalangy caused by an accessory bone between the second metacarpal and proximal phalanx known as Manzke dysostosis. Here we present the first case of molecularly confirmed Catel–Manzke syndrome with Robin sequence but without Manzke dysostosis.
Draft Genome Sequence of Cyclobacterium marinum Strain Atlantic-IS, Isolated from the Atlantic Slope off the Coast of Virginia, USA

Here, we report a draft genome sequence for Cyclobacterium marinum strain Atlantic-IS, isolated from the Atlantic slope off the coast of Virginia. The whole-genome sequence will help us understand its adaptive metabolic responses to diverse C sources in low-nutrient environments. ABSTRACT Here, we report a draft genome sequence for Cyclobacterium marinum strain Atlantic-IS, isolated from the Atlantic slope off the coast of Virginia. The whole-genome sequence will help us understand its adaptive metabolic responses to diverse C sources in low-nutrient environments.
Transcutaneous Cancer Vaccine using a Reverse Micellar Antigen Carrier.

Skin dendritic cells (DCs) such as langerhans cells and dermal dendritic cells have a pivotal role in inducing antigen specific immunity; therefore, transcutaneous cancer vaccines are a promising strategy to prophylactically prevent the onset of a variety of diseases, including cancers. The largest obstacle to delivering antigen to these skin DC subsets is the barrier function of the stratum corneum. Although reverse micellar carriers are commonly used to enhance skin permeability to hydrophilic drugs, the transcutaneous delivery of antigen, proteins, or peptides has not been achieved to date because of the large molecular weight of drugs. To achieve effective antigen delivery to skin DCs, we developed a novel strategy using a surfactant as a skin permeation enhancer in a reverse micellar carrier. In this study, glyceryl monooleate (MO) was chosen as a skin permeation enhancer, and the MO-based reverse micellar carrier enabled the successful delivery of antigen to langerhans cells and dermal dendritic cells. Moreover, transcutaneous vaccination with the MO-based reverse micellar carrier significantly inhibited tumor growth, indicating that it is a promising vaccine platform against tumors.
The Effect of Adaptive Sports on Individuals with Acquired Neurological Disabilities and Its Role in Rehabilitation: A Systematic Review.

The aims of this systematic review were to report on the feasibility of adaptive sports for individuals with acquired central neurological lesion; to analyze the effects of this approach according to the domains of the International Classification of Functioning, Health and Disability (ICF); and to emit guiding points for future research. Two authors searched PubMed, Scopus, Cochrane, Pedro, and SPORTdiscus for eligible trials. Data concerning demographics, outcome measures, results, and conclusions were extracted, and a qualitative synthesis was performed. Adaptive sports seem to be a feasible, efficient, and cost-effective complement to conventional rehabilitation. Significant effects were found on all domains of the ICF, except "environmental factors. " Key factors, such as intervention volume, intensity, and type, play a determining role. This review is the first to expose the beneficial effects of adaptive sports practice among individuals with neurological lesions by relying on prospective evidence.
Investigating the Oxidation Step in the CuCl2-Catalyzed Aerobic Oxidative Coupling Reaction of N-Aryl Tetrahydroisoquinolines.

The oxidative coupling of N-aryl tetrahydroisoquinolines with nucleophiles has inspired the development of novel C-H functionalization reactions as well as mechanistic studies. Here, we investigate the oxidation step that forms iminium ions as key intermediates in the method using CuCl2 as catalyst and oxygen as terminal oxidant. A strong electronic effect of substituents in the N-aryl ring was found by synthetic studies and a Hammett plot analysis, supporting initial electron transfer from the amine to Cu(II). The importance of the mechanism of oxidation on the substrate scope with differently substituted tetrahydroisoquinolines is discussed.
Low-Rank Matrix Recovery via Modified Schatten- $p$ Norm Minimization With Convergence Guarantees

In recent years, low-rank matrix recovery problems have attracted much attention in computer vision and machine learning. The corresponding rank minimization problems are both combinational and NP-hard in general, which are mainly solved by both nuclear norm and Schatten-<italic>p</italic> (<inline-formula> <tex-math notation="LaTeX">$0 < {p} < 1$ </tex-math></inline-formula>) norm based optimization algorithms. However, inspired by weighted nuclear norm and Schatten-<italic>p</italic> norm as the relaxations of rank function, the main merits of this work firstly provide a modified Schatten-<italic>p</italic> norm in the affine matrix rank minimization problem, denoted as the modified Schatten-<italic>p</italic> norm minimization (MS<italic><sub>p</sub></italic>NM). Secondly, its surrogate function is constructed and the equivalence relationship with the MS<italic><sub>p</sub></italic>NM is further achieved. Thirdly, the iterative singular value thresholding algorithm (ISVTA) is devised to optimize it, and its accelerated version, i.e., AISVTA, is also obtained to reduce the number of iterations through the well-known Nesterov’s acceleration strategy. Most importantly, the convergence guarantees and their relationship with objective function, stationary point and variable sequence generated by the proposed algorithms are established under some specific assumptions, e.g., Kurdyka-Łojasiewicz (K) property. Finally, numerical experiments demonstrate the effectiveness of the proposed algorithms in the matrix completion problem for image inpainting and recommender systems. It should be noted that the accelerated algorithm has a much faster convergence speed and a very close recovery precision when comparing with the proposed non-accelerated one.
Precise Drug Delivery by Using PLGA-Based Microspheres and Optical Manipulators

The accurate delivery of precise amounts of drugs to a specific location can considerably affect various clinical applications. The precise control of drug amount and position is crucial to a successful drug delivery. This paper proposes the use of poly(lactide-co-glycolicacid) (PLGA)-based microspheres to contain precise amounts of drugs and an optical tweezer manipulator to transport these drug-containing microspheres to their targeted sites in vivo. The drugs were delivered by the PLGA-based microspheres to the yolk sac of zebrafish embryos, and a sustained drug release was observed to examine the anti-angiogenesis and angiogenesis activities. The PLGA-based microspheres degraded in zebrafish, thereby verifying that these microspheres can be used as drug carriers in vivo to ensure good biocompatibility and biodegradation. The proposed precise drug delivery approach can be used in protein tests and drug property characterization in vivo.
Evaluation of an Integrin αvβ3 and Aminopeptidase N Dual-receptor Targeting Tracer for Breast Cancer Imaging.

Integrin αvβ3 and aminopeptidase N (APN, also known as CD13) are two important targets involved in the regulation of angiogenesis, tumor proliferation, invasion and metastasis. In this study, we developed a heterodimeric tracer consisting of arginine-glycine-aspartic (RGD) and asparagine-glycine-arginine (NGR) peptides targeting αvβ3 and CD13, respectively, for PET imaging of breast cancer. NGR peptide was first modified with N3-NOtB2 and then conjugated to BCN-PEG4-c(RGDyK) via copper free click chemistry. The resulting precursor was purified and radiolabeled with Gallium-68. Small animal PET/CT imaging and post-imaging biodistribution studies were performed in mice bearing human breast cancer MCF-7, MDA-MB-231, MDA-MB-468 and MX-1 xenografts and pulmonary metastases models. The expression levels of αvβ3 and CD13 in tumors were checked via immunochemical staining. The heterodimeric tracer was successfully synthesized and radiolabeled with Gallium-68 at a molar activity of 45~100 MBq/nmol at the end of synthesis. It demonstrated high in vitro and in vivo stability. In static PET/CT imaging studies, MCF-7 tumor could be clearly visualized and exhibited higher uptake at 30 min post injection (p.i.) of 68Ga-NGR-RGD than that of either 68Ga-RGD or 68Ga-NGR alone. High specificity was shown in blocking studies using RGD and NGR peptides. MCF-7 tumor exhibited the highest uptake of 68Ga-NGR-RGD, followed by MDA-MB-231, MDA-MB-468, and MX-1 tumors. This was consistent with their expression levels of CD13 and αvβ3 as confirmed by western blot and immunohistochemical staining. Metastatic lesions in lung were clearly detectable on 68Ga-NGR-RGD PET/CT imaging in mouse models of pulmonary metastases. 68Ga-NGR-RGD, a CD13 and αvβ3 dual-receptor targeting tracer showed higher binding avidities, targeting efficiency, and longer tumor retention time compared with monomeric 68Ga-NGR and 68Ga-RGD. Its promising in vivo performance makes it an ideal candidate for future clinical translation.
Mycobacterium tuberculosis HN878 infection induces human-like B cell follicles in mice.

Specific spatial organization of granulomas within the lungs is crucial for protective anti-tuberculosis (TB) immune responses. However, only large animal models such as macaques are thought to reproduce the morphological hallmarks of human TB granulomas. In this study, we show that infection of mice with clinical "hypervirulent" Mycobacterium tuberculosis (Mtb) HN878 induces human-like granulomas composed of bacilli-loaded macrophages surrounded by lymphocytes and organized localization of germinal centers and B cell follicles. Conversely, infection with lab-adapted Mtb H37Rv resulted in granulomas that are characterized by unorganized clusters of macrophages scattered between lymphocytes. An in-depth exploration of the functions of B cells within these follicles suggested diverse roles and the activation of signaling pathways associated with antigen presentation and immune cell recruitment. These findings support the use of clinical Mtb HN878 strain for infection in mice as an appropriate model to study immune parameters associated with human TB granulomas.
Variable association of 24-h peripheral and central hemodynamics and stiffness with hypertension-mediated organ damage: the VASOTENS Registry.

OBJECTIVE In this analysis of the telehealth-based Vascular health ASsessment Of The hypertENSive patients Registry, we checked how 24-h central and peripheral hemodynamics compare with hypertension-mediated organ damage (HMOD). METHODS In 646 hypertensive patients (mean age 52 ± 16 years, 54% males, 65% treated) we obtained ambulatory brachial and central SBP and pulse pressure (PP), SBP, and PP variability, pulse wave velocity and augmentation index with a validated cuff-based technology. HMOD was defined by an increased left ventricular mass index (cardiac damage, evaluated in 482 patients), an increased intima-media thickness (vascular damage, n = 368), or a decreased estimated glomerular filtration rate or increased urine albumin excretion (renal damage, n = 388). RESULTS Ambulatory SBP and PPs were significantly associated with cardiac damage: the largest odds ratio was observed for 24-h central SBP [1.032 (1.012, 1.051), P = 0.001] and PP [1.042 (1.015, 1.069), P = 0.002], the weakest for brachial estimates. The association was less strong for vascular damage with a trend to the superiority of 24-h central [1.036 (0.997, 1.076), P = 0.070] over brachial PP [1.031 (1.000, 1.062), P = 0.052]. No statistically significant association was observed for renal damage. SBP and PP variabilities, pulse wave velocity and augmentation index were not associated with any form of HMOD. In the multivariate analysis, age was associated with any type of HMOD, whereas central SBP and PP were predictive of an increased risk of cardiac damage. CONCLUSION In hypertensive patients a variable association exists between peripheral and central hemodynamics and various types of HMOD, with the most predictive power being observed for central SBP and PP for cardiac damage.
Psychological factors that determine people's willingness‐to‐share genetic data for research

Of all the information that we share, health and genetic data might be among the most valuable for researchers. As data are handled as particularly sensitive information, a number of pressing issues regarding people's preferences and privacy concerns are raised. The goal of the present study was to contribute to an understanding of people's reported willingness‐to‐share genetic data for science (WTS). For this, predictive psychological factors (eg, risk and benefit perceptions, trust, knowledge) were investigated in an online survey (N = 416). Overall, participants seemed willing to provide their genetic data for research. Participants who perceived more benefits associated with data sharing were particularly willing to share their data for research (β = .29), while risk perceptions were less influential (β = −.14). As participants with higher knowledge of the potential uses of genetic data for research perceived more benefits (β = .20), WTS can likely be improved by providing people with information regarding the usefulness of genetic data for research. In addition to knowledge and perceptions, trust in data recipients increased people's willingness‐to‐share directly (β = .24). Especially in the sensitive area of genetic data, future research should strive to understand people's shifting perceptions and preferences.
Exclude me, enjoy us? Unmitigated communion and relationship satisfaction across 7 years.

This study explored 2 key questions at the intersection of care, well-being, and development in romantic relationships. First, what are the links between unmitigated communion (i.e., being overinvolved with meeting a partner's needs to the exclusion of one's own needs) and both partners' relationship satisfaction over time? Second, are there gender differences in the longitudinal links between unmitigated communion and relationship satisfaction? We answered these questions using data from 1,340 couples who participated in the German Family Panel over a 7-year period. Latent change score modeling results revealed that on average, people declined in both unmitigated communion and relationship satisfaction over time, and these declines occurred in concert with each other across each wave: A more rapid decrease in unmitigated communion occurred in tandem with a more rapid decrease in relationship satisfaction. Furthermore, higher initial levels of unmitigated communion predicted a slower rate of decline in relationship satisfaction, and higher initial levels of satisfaction stabilized future declines in unmitigated communion. Lastly, higher initial relationship satisfaction among men predicted a more gradual decline in female partners' unmitigated communion, but women's satisfaction did not predict male partners' unmitigated communion. Overall, this is the first study to demonstrate the codevelopment of and bidirectionality between unmitigated communion and relationship satisfaction in established romantic relationships. Unmitigated communion and relationship satisfaction tend to bolster each other in ways that protect them from steeper declines across time, which may explain why people continue to give in relationships when it is personally costly to themselves. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Sequencing of Androgen-Deprivation Therapy With External-Beam Radiotherapy in Localized Prostate Cancer: A Phase III Randomized Controlled Trial.

PURPOSE Dose-escalated radiotherapy (RT) with androgen-deprivation therapy (ADT) is a standard definitive treatment of localized prostate cancer (LPCa). The optimal sequencing of these therapies is unclear. Our phase III trial compared neoadjuvant versus concurrent initiation of ADT in combination with dose-escalated prostate RT (PRT). PATIENTS AND METHODS Patients with newly diagnosed LPCa with Gleason score ≤ 7, clinical stage T1b to T3a, and prostate-specific antigen < 30 ng/mL were randomly allocated to neoadjuvant and concurrent ADT for 6 months starting 4 months before RT (neoadjuvant group) or concurrent and adjuvant ADT for 6 months starting simultaneously with RT (concurrent group). The primary end point was biochemical relapse-free survival (bRFS). Stratified log-rank test was used to compare bRFS and overall survival (OS). Incidence of grade ≥ 3 late RT-related toxicities was compared by log-rank test. RESULTS Overall, 432 patients were randomly assigned to the neoadjuvant (n = 215) or concurrent group (n = 217). At 10 years, bRFS rates for the two groups were 80.5% and 87.4%, respectively. Ten-year OS rates were 76.4% and 73.7%, respectively. There was no significant difference in bRFS (P = .10) or OS (P = .70) between the two groups. Relative to the neoadjuvant group, the hazard ratio for the concurrent group was 0.66 (95% CI, 0.41 to 1.07) for bRFS and 0.94 (95% CI, 0.68 to 1.30) for OS. No significant difference was observed in the 3-year incidence of late RT-related grade ≥ 3 GI (2.5% v 3.9%) or genitourinary toxicity (2.9% v 2.9%). CONCLUSION In our study, there was no statistically significant difference in bRFS between the two treatment groups. Similarly, no difference was seen in OS or late RT-related toxicities. On the basis of these results, both neoadjuvant and concurrent initiations of short-term ADT with dose-escalated PRT are reasonable standards of care for LPCa.
Transcutaneous Carbon Dioxide Monitoring During Apnea Testing for Determination of Neurologic Death in Children: A Retrospective Case Series*

Objectives: Determination of neurologic death in children is a clinical diagnosis based on absence of neurologic function with irreversible coma and apnea. Apnea testing during determination of neurologic death assesses spontaneous respiration when Paco2 increases to greater than or equal to 60 and greater than or equal to 20 mm Hg above pre-apneic baseline. The utility of transcutaneous carbon dioxide measurements during apnea testing in children is unknown. We seek to determine the degree of correlation between paired transcutaneous carbon dioxide and Paco2 values during apnea testing for determination of neurologic death. Design: Single-center, retrospective case series. Setting: Twenty-eight bed PICU in a 259-bed, tertiary care, referral center. Patients: Children 0–18 years old undergoing determination of neurologic death between May 2017 and December 2018. Interventions: None. Measurements and Main Results: Primary outcomes were paired transcutaneous carbon dioxide and Paco2 values obtained during determination of neurologic death. Primary analyses included Pearson correlation coefficient, Bland-Altman bias and limits of agreement, and comparative statistics. Descriptive data included demographics, admission diagnoses, hemodynamics, Vasoactive Inotropic Scores, and arterial blood gas measurement. Eight children underwent 15 determination of neurologic death examinations resulting in 31 paired transcutaneous carbon dioxide and Paco2 values for study. Transcutaneous carbon dioxide and Paco2 correlated well (r = 0.94; p < 0.01). Bias between transcutaneous carbon dioxide and Paco2 was –3.29 ± 7.14 mm Hg. Differences in means did not correlate with Vasoactive Inotropic Score (r = 0.2) or patient temperature (r = 0.11). Receiver operator characteristic curve of transcutaneous carbon dioxide after 3–10 minutes of apnea to discriminate positive apnea testing by the standard of Paco2 yielded an area under the curve of 0.91 and threshold of greater than or equal to 64 mm Hg (sensitivity, 91.7%; specificity, 100%; positive predictive value, 100%; negative predictive value, 92.3%; accuracy, 95.9%). Conclusions: During apnea testing for determination of neurologic death in children, noninvasive transcutaneous carbon dioxide monitoring demonstrated high correlation, accuracy, and minimal bias when compared with Paco2. Further validation is required before any recommendation to replace Paco2 with noninvasive transcutaneous carbon dioxide monitoring can be proposed. However, concurrent transcutaneous carbon dioxide data may limit unnecessary apnea time and associated hemodynamic instability or respiratory decompensation by approximating goal arterial blood sampling to document target Paco2.
Morality is relative: Anger, disgust, and aggression as contingent responses to sibling versus acquaintance harm.

Angry reactions to moral violations should be heightened when wrongs befall oneself in comparison with when wrongs befall acquaintances, as prior research by Molho, Tybur, Güler, Balliet, and Hofmann (2017) demonstrates, because aggressive confrontation is inherently risky and therefore only incentivized by natural selection to curtail significant fitness costs. Here, in 3 preregistered studies, we extend this sociofunctional perspective to cases of wrongs inflicted on siblings. We observed equivalently heightened anger in response to transgressions against either oneself or one's sibling relative to transgressions against acquaintances across studies, whereas transgressions against acquaintances evoked greater disgust and/or fear (both associated with social avoidance) in 2 of the 3 studies. Studies 2 and 3, which incorporated measures of tendencies to confront the transgressor, confirmed that the elevated anger elicited by self or sibling harm partially mediated heightened inclinations toward direct aggression. Finally, in Study 3 we compared tendencies to experience anger and to directly aggress on behalf of siblings and close friends. Despite reporting greater affiliative closeness for friends than for siblings, harm to friends failed to evoke heightened anger relative to acquaintance harm, and participants were inclined to directly aggress against those who had harmed their sibling to a significantly greater extent than when the harm befell their friend. These overall results broadly replicate Molho et al.'s (2017) findings and theoretically extend the sociofunctionalist account of moral emotions to kinship. (PsycINFO Database Record (c) 2019 APA, all rights reserved).