Miracle-dz/UniFAR-FTUs huggingface dataset:
A Context Transfer Model for Secure Handover in WiMAX/LTE Integrated Networks

One of the recent research issues in IP Multimedia Subsystem IMS based heterogeneous internetworking environment is to provide secure handover when a mobile node MN moves between different access networks. Various security schemes are available in literature but most of the schemes provide security but degrades the Quality of Service QoS. The objective of this work is to provide secure and efficient handover in an IMS based Worldwide Interoperability for Microwave access WiMAX/ Long Term Evolution LTE integrated networks by using the proposed Secure Context Transfer Model SCTM. New Session Initiation Protocol SIP messages are introduced in the proposed SCTM for transferring the context securely from old Proxy-Call session control function P-CSCF server to new P-CSCF server during handover. SCTM is verified using NS-2 simulator and analyzed based on Queuing theory. The results show that when compared with previous approaches, SCTM shows an improvement of 23% in terms of handover delay and packet loss providing security and guaranteed QoS to mobile users.
Microrheology of complex fluids T A Waigh Influence of the photothermal effect of a gold nanorod cluster on biofilm disinfection

Bacteria living on surfaces form heterogeneous three-dimensional consortia known as biofilms, where they exhibit many specific properties one of which is an increased tolerance to antibiotics. Biofilms are maintained by a polymeric network and display physical properties similar to that of complex fluids. In this work, we address the question of the impact of antibiotic treatment on the physical properties of biofilms based on recently developed tools enabling the in situ mapping of biofilm local mechanical properties at the micron scale. This approach takes into account the material heterogeneity and reveals the spatial distribution of all the small changes that may occur in the structure. With an Escherichia coli biofilm, we demonstrate using in situ fluorescent labeling that the two antibiotics ofloxacin and ticarcillin—targeting DNA replication and membrane assembly, respectively—induced no detectable alteration of the biofilm mechanical properties while they killed the vast majority of the cells. In parallel, we show that a proteolytic enzyme that cleaves extracellular proteins into short peptides, but does not alter bacterial viability in the biofilm, clearly affects the mechanical properties of the biofilm structure, inducing a significant increase of the material compliance. We conclude that conventional biofilm 4 Author to whom any correspondence should be addressed. Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. New Journal of Physics 15 (2013) 125026 1367-2630/13/125026+17$33.00 © IOP Publishing Ltd and Deutsche Physikalische Gesellschaft
The SIX1-EYA transcriptional complex as a therapeutic target in cancer

Introduction: The SIX homeodomain proteins and the eyes absent (EYA) family of co-activators form a bipartite transcription factor complex that promotes the proliferation and survival of progenitor cells during organogenesis and is down-regulated in most adult tissues. Abnormal over-expression of SIX1 and EYA in adult tissue is associated with the initiation and progression of diverse tumor types. Importantly, SIX1 and EYA are often co-overexpressed in tumors, and the SIX1-EYA2 interaction has been shown to be critical for metastasis in a breast cancer model. The EYA proteins also contain protein tyrosine phosphatase activity, which plays an important role in breast cancer growth and metastasis as well as directing cells to the repair pathway upon DNA damage. Areas covered: This review provides a summary of the SIX1/EYA complex as it relates to development and disease and the current efforts to therapeutically target this complex. Expert opinion: Recently, there have been an increasing number of studies suggesting that targeting the SIX1/EYA transcriptional complex will potently inhibit tumor progression. Although current attempts to develop inhibitors targeting this complex are still in the early stages, continued efforts toward developing better compounds may ultimately result in effective anti-cancer therapies.
Reaching and Retaining High-Risk HIV/AIDS Clients Through the Internet

The Internet is a popular way for people to meet casual sex partners. However, online outreach remains largely unexplored to promote voluntary counseling and testing for HIV. The Student Health Action Coalition’s HIV testing program (SHAC-HIV) targets high-risk clients through tailored Internet outreach via chat rooms, social networking sites, and online forums. The SHAC-HIV model also demonstrates that nontraditional testing sites can provide low-cost, client-centered, high-quality services to support increased demand for HIV-testing services. Within the clinic, SHAC-HIV’s testing model includes four major components: (a) reliance on a team of well-trained health sciences student volunteers; (b) rapid oral-fluid HIV tests; (c) universal, consent-based testing with client-centered health education and counseling; and (d) coordinated referrals for follow-up testing, treatment, and care. This approach reaches high-risk clients as well as undiagnosed infections. In 2007, there were nine confirmed positive results out of 389 tests, yielding a 2.3% positivity rate. This positivity percentage is higher than any other nontraditional testing site in North Carolina. This article describes the SHAC-HIV outreach and vo-luntary counseling and testing program with the aim of encouraging adoption of the model by other nontraditional testing sites.
Efficient Endocytic Uptake and Maturation in Drosophila Oocytes Requires Dynamitin/p50

Dynactin is a multi-subunit complex that functions as a regulator of the Dynein motor. A central component of this complex is Dynamitin/p50 (Dmn). Dmn is required for endosome motility in mammalian cell lines. However, the extent to which Dmn participates in the sorting of cargo via the endosomal system is unknown. In this study, we examined the endocytic role of Dmn using the Drosophila melanogaster oocyte as a model. Yolk proteins are internalized into the oocyte via clathrin-mediated endocytosis, trafficked through the endocytic pathway, and stored in condensed yolk granules. Oocytes that were depleted of Dmn contained fewer yolk granules than controls. In addition, these oocytes accumulated numerous endocytic intermediate structures. Particularly prominent were enlarged endosomes that were relatively devoid of Yolk proteins. Ultrastructural and genetic analyses indicate that the endocytic intermediates are produced downstream of Rab5. Similar phenotypes were observed upon depleting Dynein heavy chain (Dhc) or Lis1. Dhc is the motor subunit of the Dynein complex and Lis1 is a regulator of Dynein activity. We therefore propose that Dmn performs its function in endocytosis via the Dynein motor. Consistent with a role for Dynein in endocytosis, the motor colocalized with the endocytic machinery at the oocyte cortex in an endocytosis-dependent manner. Our results suggest a model whereby endocytic activity recruits Dynein to the oocyte cortex. The motor along with its regulators, Dynactin and Lis1, functions to ensure efficient endocytic uptake and maturation.
Hamiltonian Model of Hydro Turbine with Sharing Common Conduit

To bring the hydro turbine and hydraulic system into the theory frame of the generalized Hamiltonian and study the dynamic mechanism of its operation and control, the model of its Hamiltonian system is studied in this paper. Based on the differential equation model of hydro turbine decomposed hydraulic dynamics with sharing common conduit, by constructing the Hamiltonian function of hydraulic turbine, the nonlinear model of hydro turbine is converted to Hamiltonian system by adopting orthogonal decomposition realization, and it is realized into Hamiltonian dissipative forms by decomposing the structure matrix and designing the dissipative feedback. The variation of dissipative structure, feedback equivalence and energy flow in built Hamiltonian model are studied, the energy flows of Hamiltonian are consistent with actual system in description of generalized energy. Simulation indicates that the Hamiltonian function contains detailed main information of energy change of hydraulic turbine in transient, and is feasible.
Coupled Van Der Pol oscillators utilised as Central pattern generators for quadruped locomotion

Central pattern generators (CPGs) inspired from neural system of animal are widely used for the control of locomotion in robots. The objective of this paper is to modeling a CPG-network formed by a set of mutually coupled Van Der Pol (VDP) oscillators to generating rhythmic movement patterns for multi-joint robot. Firstly, a VDP-CPG network is made up by four coupled VDP oscillators, which can produce multiple phase-locked oscillation patterns that correspond to the four basic quadrupedal gaits. Then the gait transitions between the different gaits are generated by altering the internal oscillator parameters. At last, we use VDP-CPG network to produce the joints trajectories for AIBO to control the locomotion. The simulation and experimental results demonstrate that the designed VDP-CPG network is effective to control the quadruped locomotion.
Animation Setup Transfer for 3D Characters

We present a general method for transferring skeletons and skinning weights between characters with distinct mesh topologies. Our pipeline takes as inputs a source character rig (consisting of a mesh, a transformation hierarchy of joints, and skinning weights) and a target character mesh. From these inputs, we compute joint locations and orientations that embed the source skeleton in the target mesh, as well as skinning weights to bind the target geometry to the new skeleton. Our method consists of two key steps. We first compute the geometric correspondence between source and target meshes using a semi‐automatic method relying on a set of markers. The resulting geometric correspondence is then used to formulate attribute transfer as an energy minimization and filtering problem. We demonstrate our approach on a variety of source and target bipedal characters, varying in mesh topology and morphology. Several examples demonstrate that the target characters behave well when animated with either forward or inverse kinematics. Via these examples, we show that our method preserves subtle artistic variations; spatial relationships between geometry and joints, as well as skinning weight details, are accurately maintained. Our proposed pipeline opens up many exciting possibilities to quickly animate novel characters by reusing existing production assets.
Prolonged embryogenesis in Austrobaileya scandens (Austrobaileyaceae): its ecological and evolutionary significance.

The embryology of basal angiosperm lineages (Amborella, Nymphaeales and Austrobaileyales) is central to reconstructing the early evolution of flowering plants. Previous studies have shown that mature seeds in Austrobaileyales are albuminous, with a small embryo surrounded by a substantial diploid endosperm. However, little is known of seed ontogeny and seedling germination in Austrobaileya scandens, sister to all other extant Austrobaileyales. Standard histochemical techniques were used to study ovule/seed development and germination of Austrobaileya. Early development of the endosperm in Austrobaileya is ab initio cellular with pronounced cell proliferation. The nucellus transiently accumulates some starch, but is obliterated by expansion of a massive endosperm, where all embryo-nourishing reserves are ultimately stored. Twelve months elapse from fertilization to fruit abscission. Seeds are dispersed with a minute embryo, requiring 12 additional months for seedling establishment. The 2 yr required for seedling establishment is an apomorphic feature of Austrobaileya, probably related to germination in extremely dark understory conditions. Remarkably, although Austrobaileya seeds are nearly 50 times larger (by length) than the smallest seeds of extinct and extant members of early divergent angiosperm lineages, the embryo to seed ratio (E : S) falls squarely within the narrow range that characterizes the albuminous seeds of ancient flowering plant lineages.
Effect of green tea catechins with or without caffeine on anthropometric measures: a systematic review and meta-analysis.

BACKGROUND Green tea catechins (GTCs) with or without caffeine have been studied in randomized controlled trials (RCTs) for their effect on anthropometric measures and have yielded conflicting results. OBJECTIVE The objective was to perform a systematic review and meta-analysis of RCTs of GTCs on anthropometric variables, including body mass index (BMI), body weight, waist circumference (WC), and waist-to-hip ratio (WHR). DESIGN A systematic literature search of MEDLINE, EMBASE, CENTRAL, and the Natural Medicines Comprehensive Database was conducted through April 2009. RCTs that evaluated GTCs with or without caffeine and that reported BMI, body weight, WC, or WHR were included. The weighted mean difference of change from baseline (with 95% CIs) was calculated by using a random-effects model. RESULTS Fifteen studies (n = 1243 patients) met the inclusion criteria. On meta-analysis, GTCs with caffeine decreased BMI (-0.55; 95% CI: -0.65, -0.40), body weight (-1.38 kg; 95% CI: -1.70, -1.06), and WC (-1.93 cm; 95% CI: -2.82, -1.04) but not WHR compared with caffeine alone. GTC ingestion with caffeine also significantly decreased body weight (-0.44 kg; 95% CI: -0.72, -0.15) when compared with a caffeine-free control. Studies that evaluated GTCs without concomitant caffeine administration did not show benefits on any of the assessed anthropometric endpoints. CONCLUSIONS The administration of GTCs with caffeine is associated with statistically significant reductions in BMI, body weight, and WC; however, the clinical significance of these reductions is modest at best. Current data do not suggest that GTCs alone positively alter anthropometric measurements.
Feeling Both Victim and Perpetrator

Victimized versus perpetrating individuals or groups are known to experience enhanced needs for empowerment or acceptance, respectively. The present research examined the emotional needs and consequent anti- and prosocial behaviors (e.g., vengefulness vs. helpfulness) of individuals or groups serving both as victims and perpetrators simultaneously (“duals”). Focusing on interpersonal transgressions, Study 1 used variations of the dictator game to induce participants with victimization, perpetration, duality, or none (control). Duals showed heightened needs for both empowerment and acceptance and equal willingness to reconcile following either empowering or accepting messages from their adversaries. However, duals’ need for empowerment overrode their need for acceptance in determining behavior. Similar to victims, and unlike perpetrators, duals showed greater antisocial (rather than prosocial) behavior. Study 2 replicated this pattern on the intergroup level, inducing Israeli Jews with victimization, perpetration, or duality using a recall task referring to the Israeli–Palestinian conflict. Theoretical and practical implications are discussed.
Rab7 Regulates Late Endocytic Trafficking Downstream of Multivesicular Body Biogenesis and Cargo Sequestration*

The small molecular weight G-protein RAB7 is localized to both early and late endosomes and has been shown to be critical for trafficking through the endocytic pathway. The role of RAB7 in the endocytic pathway has been controversial, with some groups reporting that it regulates trafficking from early to late endosomes and others ascribing its role to trafficking between late endosomes and lysosomes. In this study, we use RNA interference to identify the exact step RAB7 regulates in the movement of the epidermal growth factor receptor (EGFR) from the cell surface to the lysosome. In the absence of RAB7, trafficking of the EGF·EGFR complex through the early endosome to the late endosome/multivesicular body (LE/MVB) does not change, but exiting from the LE/MVB is blocked. Ultrastructural analysis reveals that RAB7 is not required for formation of intraluminal vesicles of the LE/MVB, since RAB7-deficient cells have an increased number of enlarged LE/MVBs densely packed with intraluminal vesicles. Biochemical data indicate that the EGFR complex is sequestered in these intraluminal vesicles. Together, these data provide evidence that RAB7 is required for the transfer of cargo from the LE/MVB to the lysosome and for endocytic organelle maintenance.
A bi-dimensional coding scheme applied to audio bitrate reduction

We present an audio bidimensional encoding scheme. Taking advantage of a new complex filter-bank, and of a regular lattice associated with a new hexagonal projection kernel, this scheme provides each step of the encoder and of the decoder with fast algorithms, which keeps the overall complexity low. Moreover variable or fix length encodings are available without a look-up table. The results show a very good quality at 80 kbit/s for monophonic signals, and a significant improvement with respect to normalized algorithms of a similar complexity.
Proceedings of the 2008 ACM Workshop on Wireless Networks and Systems for Developing Regions, San Francisco, California, USA, September 19, 2007

It is our great pleasure to welcome you to the new ACM Workshop on Wireless Networks and Systems for Developing Regions -- WiNS-DR'08. This workshop focuses on the technology required to provide communications and information access to rural regions in the developing world, and in particular technical aspects of wireless networking, systems and communication. This target environment poses unique system-wide challenges that require the development of new research approaches and innovative designs and techniques. These challenges include infrastructure issues, such as power and connectivity limitations, as well as particular user needs, including cost, literacy and language issues. Thus in addition to considering the specifics of networking protocols and architectures, the aim of the workshop is to consider the entire system by which networking and communication is provided, all the key technical stakeholders, and the overall system lifecycle from economic modeling to deployment. Why this workshop? Wireless systems for developing regions represent an exciting but underutilized opportunity for large-scale impact on the economic livelihood and well-being of the population in these areas. In addition it is clear that the fastest growing markets for wireless technology are in these regions. The special challenges faced in these regions lead to a host of complex and interesting R&D problems that require innovation. What is in the Program? The program committee received papers from India, Malaysia, South Africa, Sweden, Uganda, UK and the US. Each paper received multiple peer reviews from the program committee and 6 were selected for publication. In addition we invited 3 papers from respected experts in the field. The resulting program is organized into three major sessions on Deployment Experience, the specific technical challenges of Delay Tolerant Networking, and a broader session on Policy, Platforms and Architectures. How do I get involved further? Participate in the workshop, propose ideas to follow on the workshop or for next year, write a paper, and contact us to volunteer to help!
Regulation of a Transient Receptor Potential (TRP) Channel by Tyrosine Phosphorylation

The recently identified transient receptor potential (TRP) channel family member, TRPV4 (formerly known as OTRPC4, VR-OAC, TRP12, and VRL-2) is activated by hypotonicity. It is highly expressed in the kidney as well as blood-brain barrier-deficient hypothalamic nuclei responsible for systemic osmosensing. Apart from its gating by hypotonicity, little is known about TRPV4 regulation. We observed that hypotonic stress resulted in rapid tyrosine phosphorylation of TRPV4 in a heterologous expression model and in native murine distal convoluted tubule cells in culture. This tyrosine phosphorylation was sensitive to the inhibitor of Src family tyrosine kinases, PP1, in a dose-dependent fashion. TRPV4 associated with Src family kinases by co-immunoprecipitation studies and confocal immunofluorescence microscopy, and this interaction required an intact Src family kinase SH2 domain. One of these kinases, Lyn, was activated by hypotonic stress and phosphorylated TRPV4 in an immune complex kinase assay and an in vitro kinase assay using recombinant Lyn and TRPV4. Transfection of wild-type Lyn dramatically potentiated hypotonicity-dependent TRPV4 tyrosine phosphorylation whereas dominant negative-acting Lyn modestly inhibited it. Through mutagenesis studies, the site of tonicity-dependent tyrosine phosphorylation was mapped to Tyr-253, which is conserved across all species from which TRPV4 has been cloned. Importantly, point mutation of Tyr-253 abolished hypotonicity-dependent channel activity. In aggregate, these data indicate that hypotonic stress results in Src family tyrosine kinase-dependent tyrosine phosphorylation of the tonicity sensor TRPV4 at residue Tyr-253 and that this residue is essential for channel function in this context. This is the first example of direct regulation of TRP channel function through tyrosine phosphorylation.
Quantitative differences in the expression of a 72,000 molecular weight cell surface glycoprotein (GP72) in Trypanosoma cruzi zymodemes.

A high affinity monoclonal antibody, 8G2 B9, was used to assess the expression of a 72,000 m.w. glycoprotein ( GP72 ) in isoenzyme-typed T. cruzi strains ( zymodemes ). Western blotting analysis of T. cruzi clones showed that 8G2 B9 bound strongly to GP72 and also suggested that this antigen was absent or weakly detectable in T. cruzi zymodeme 1 (Z1) strains. Purified 8G2 B9 was radiolabeled with 125I and used in an inhibition radioimmune binding assay to compare the quantities of GP72 in different zymodemes . Ninety-six T. cruzi strains were assayed, of which 36 were Z1, 36 were Z2, five were Z3 , and 19 were Z2 (heterozygous). Most (64%) Z1 strains lacked detectable GP72 , whereas this antigen was always detected Z2 and Z2 (heterozygous) strains. There was an 18-fold difference between geometric mean values for the quantities of GP72 (expressed as nanograms per milligram total cell protein) in Z1 and Z2 strains (Z1, 36 ng/mg; Z2, 639 ng/mg; p less than 0.001). There were also significant differences between the geometric mean values for Z2 and Z2 (heterozygous) strains, i.e., 639 ng/mg and 1648 ng/mg, respectively (p less than 0.001). GP72 was detected in four of the Z3 strains in quantities ranging from 740 to 3640 ng/mg. The absolute amounts of antigen in GP72 -positive strains were low, comprising less than 1% of the total cell protein. The specificities of two other anti- GP72 monoclonal antibodies, 7C6 D7 and WIC 29.26, were compared with 8G2 B9. Both antibodies completely inhibited the binding of 8G2 B9 to GP72 in solid phase immunoassays, suggesting that they reacted with the same antigenic determinants. The results show that monoclonal antibody-based assessments of the expression of GP72 correlate with zymodeme classification, and they also suggest that the monoclonal antibodies recognize major antigenic determinants on GP72 . It should be possible to use 8G2 B9 as an immunologic marker to additionally investigate the clinical significance of T. cruzi zymodemes and the biologic significance of GP72 .