Miracle-dz/UniFAR-FTUs huggingface dataset:
Oxidimetric assay of simvastatin in pharmaceuticals using cerium (IV) and three dyes as reagents.

Three simple and sensitive spectrophotometric methods are described for the detn. of simvastatin (SMT) in bulk drug and in tablets. The methods are based on the oxidn. of SMT by a measured excess of cerium (IV) in acid medium followed by detn. of unreacted cerium (IV) by reacting with a fixed amt. of methyl orange (method A), indigo carmine (method B) or meta-cresol purple (method C) and measuring the absorbance at 510, 610, or 540 nm. In all the methods, the amt. of cerium (IV) reacted corresponds to the amt. of SMT. The exptl. conditions for the assay have been optimized. In all the methods, the absorbance is found to increase linearly with the concn. of SMT at the resp. wavelengths. Beer's law is obeyed over the ranges 0.6-6, 2.5-25, and 2.5-25 I¼g/mL-1 for method A, method B, and method C, resp. and the resp. molar absorptivity values are 4.0 A— 104, 6.3 A— 103, and 6.3 A— 103 L/mol-1/cm-1. The limits of detection and quantification are reported for all the methods. The performance of the methods was validated according to the present ICH guidelines. The methods gave similar results in terms of precision and accuracy. The repeatability and intermediate precision, expressed by the RSD was better than 4%. The accuracy of the methods expressed as relative error was satisfactory. The proposed methods were applied to the anal. of tablet form of SMT and the results tallied well with the label claim. No interference was obsd. from the concomitant substances normally added to tablets. The results were statistically compared with those of a literature method by applying the Student's t-test and F-test. The accuracy and validity of the methods were further ascertained by performing recovery studies via spike method. [on SciFinder(R)]
Impact du PUGNAc sur le catabolisme des N-glycoprotéines

Les Oligosaccharides soluble (OS) sont essentiellement generes durant le processus de degradation des N-glycoproteines nouvellement synthetisees et mal conformees (ERAD) et durant la voie « turn-over » des glycoproteines matures. Dans le but de determiner si la modification post-traductionnelle O-GlcNAc est effectivement impliquee dans le processus de degradation des N-glycoproteines, nous avons analyse par spectrometrie de masse les OS provenant des cellules CHO apres traitement par l’inhibiteur PUGNAc. Le PUGNAc ou « O-(2-acetamido-2-deoxy-D-glucopyranosylidene) amino-N-phenylcarbanate » est un inhibiteur puissant de l’O-GlcNAcase (OGA) qui catalyse l’hydrolyse du residu O-GlcNAc des residus serine et threonine des proteines O-GlcNAcylees.L’analyse par spectrometrie de masse revele l’apparition d’une population d’OS de structures anormaux dans les cellules CHO suite au traitement par le PUGNAc. Cette population a ete identifiee comme ayant des structures possedant des residus GlcNAc au niveau de leur extremite non-reductrice issues d’une degradation lysosomale incomplete des glycoproteines. Contrairement au PUGNAc, le NButGT, un autre inhibiteur de l’OGA, n’aboutit pas a l’apparition de cette population. Ainsi, Nous avons demontre que ces structures s’accumulent exclusivement dans la fraction membranaire consequence de l’inhibition des β-hexosaminidases lysosomaux par le PUGNAc. Notre etude avait permis, d’un part, de mettre en evidence la capacite du PUGNAc de mimer une maladie de surcharge lysosomale et, d’autre part, de montrer un autre aspect des effets indesirables induits par le PUGNAc et qui necessite d’etre pris en consideration lors de l’utilisation de cet inhibiteur.
Increasing hydrogen energy efficiency by heat integration between fuel cell, hydride tank and electrolyzer

Chemical processes offer untapped potential to increase overall system efficiencies by synergizing renewable hydrogen storage with dispatchable renewable energy facilities. In this study an Energy Storage Facility model is developed and simulation conducted to examine this potential. The model incorporates a Solid Oxide Fuel Cell (SOFC) integrated with a Magnesium Hydride (MgH2) Tank and an alkaline electrolyzer linked to the power grid. Surplus grid power is converted to hydrogen and stored as magnesium hydride. This storage process generates waste heat which is used to partially offset the water heating requirement of the electrolyzer. Simulation results demonstrate 20% reduction in parasitic heat energy consumption using this waste heat. Stored hydrogen provides power on demand via the SOFC. Waste heat from SOFC fulfils the desorption heat demand of the MgH2 Tank. Simulation results reveal waste heat from the SOFC is just enough to preheat oxygen and hydrogen and desorb hydrogen from the MgH2 tank. These results are encouraging, warranting further investigation into metal hydride storage to help Australia’s transition towards renewable energy resources.
Management structure in the performance of Polish mutual funds: Does team spirit matter?

This paper focuses on finding answers to two questions. The first one asks if there are any significant differences in performance between solo-managed and teammanaged funds. The second one is supposed to establish whether a management structure can be treated as a determinant of returns generated by mutual funds operating in Poland. The study was conducted on the basis of 835 annual observations, 388 of which concerned solo-managed funds and 447 – team-managed funds, in the period 2000-2017. The returns were calculated by means of a few popular measures of abnormal returns regarding the stock picking ability of fund managers. The methodological procedure consisted of four research tools which ensured a greater certainty of the statistical inference. The findings show that there are insignificant discrepancies in the performance of funds characterized by a different number of managers, yet they are noticeable in very few annual periods. The results obtained as an effect of determining the influence of a management structure on performance are statistically insignificant, which means that the examined variable is not a determinant of performance, at least as far as Polish circumstances are concerned.
SOCIO-ECONOMIC DETERMINANTS OF ADOPTION OF IMPROVED RICE PRODUCTION TECHNOLOGIES AMONG RICE FARMERS IN EBONYI STATE, NIGERIA: A LOGIT REGRESSION MODEL APPROACH

Adoption is a decision to make use of an innovation on a continuous basis. It is against this backdrop that this study investigated the socio-economic determinants of adoption of improved rice production technologies in Ebonyi State, Nigeria. The study employed multistage random sampling techniques in the selection of 420 rice farmers from the three agricultural zones of the state. Primary data were sourced through field survey with the aid of structured questionnaires and interview schedule. Both descriptive and inferential statistics were used in data analysis. The result of the socio-economic characteristics of the farmers shows that majority (66.67 percent) of the respondents were males whose age ranged between 41-50 years with mean age of 42 years. Most of them (62.50 percent) were married and had household size of between 6-10 persons with average household size of 8 persons. Majority (50.83 percent) were full-time farmers whose farm size ranged between 1.1-2.0 hectares. Most of the farmers (43.33 percent) had been involved in rice farming for 21-30 years and earned monthly income of between N31,000-N40,000. The result of logistic regression analysis showed a log likelihood ratio of -188. 40 and Chi-square value of 682.559 which was significant at (P= 0.01); implying that all the variables jointly determined the dependent variable. The Pseudo R2 (Nagelkerke) which was 76.6 percent implied that about 76.6 percent of the variation in the adoption of improved rice production technologies was explained by the farmers socio-economic characteristics. Most of the variables were significant and met a priori expectations. The result of factor analysis identified: technical, financial and institutional constraints as major bottlenecks limiting adoption of improved rice production technologies in the area. It was concluded that the socio-economic characteristics of the rural farmers significantly influenced their adoption of improved rice production technologies. Necessary recommendations such as: reviving youths’ interest towards rice production; employing and training more extension workers; timely provision of subsidized agricultural inputs as well as incentives for the formation of cooperative societies; were made.
Fast parameter identification of permanent magnet synchronous motor for electric vehicles

This paper designs a recurrent neural network (RNN) that can be used for both permanent magnet synchronous motor (IPMSM) parameter identification and optimal current (OC) solution for IPMSM operating efficiency optimization for electric vehicles (EVs). Firstly, the problem of parameter identification of IPMSM is modeled as a regression problem, and the least absolute deviation method (LAD) is used to estimate the parameters. Then the optimization theory and variational theory are adopted to convert it into a variational problem, and the projection dynamic equation (PDS) is utilized to obtain the solution. Finally, the RNN corresponding to the PDS is designed which can be multiplexed for the optimal solution, aims at achieving the motor parameter identification in parallel. This paper theoretically proves the convergence of the proposed projection dynamic equation, the convergence value and the identity of the PMSM parameter value to be estimated. The IPMSM drive system is built and simulated. The simulation results show that the proposed method identifies the motor parameters quickly and accurately, and it verifies the rationality and effectiveness of the proposed method.
Triazinone herbicide metribuzin induced acute liver injury: A study of animal model

Objective: To evaluate the acute toxicity effect of metribuzin at low dose on liver of mother rabbits and its fetus. Methods: Pregnant female rabbits Oryctolagus cuniculus were divided into three groups (n=5). The first group of non-treated pregnancy rabbits served as control; the second group of pregnancy rabbits were treated with 1/100 LD50 of metribuzin and the third group of pregnancy rabbits were treated with 1/50 LD50 of metribuzin. Metribuzin was added in their drinking water for 60 d before and during pregnancy. Levels of liver malondialdehyde, liver glutathione S transferase, serum glutamic oxalacetic transaminase and serum glutamic- pyruvic transaminase were determined. Liver reduced glutathione level was also determined by a colorimetric method. And hepatic homogenate was analyzed by HPLC analysis to determine the existence of traces of metribuzin. Results: Results revealed a significant increase in level of liver malondialdehyde, glutathione S transferase, serum glutamic oxalacetic transaminase and serum glutamic-pyruvic transaminase activities in mother and fetuses rabbits of both metribuzin treatment groups as compared to the control group. However the level of reduced glutathione was decreased in mother and fetuses rabbits of both groups treated with metribuzin compared to control group. Also, the results obtained by HPLC technique showed the presence of trace metribuzin in liver cells of mothers and fetuses rabbits of the both metribuzin treated groups. Conclusions: In conclusion, this study shows that exposure to metribuzin at low concentrations causes a acute toxicity in liver of mother rabbits and its fetus, also the trace of the metribuzin detected in the liver is the origin of possible malformation of the fetuses or abortion of the rabbits.
Analyse de la communauté bactérienne et de la diversité inter et intra spécifique des bactéries acétiques et lactiques impliquées dans la fermentation de cacao selon trois origines géographiques.

La fermentation du cacao est une fermentation spontanee qui dure de 4 a 8 jours et repose principalement sur la succession de trois groupes de microorganismes : les levures, les bacteries lactiques et les bacteries acetiques qui realisent les fermentations alcoolique, lactique et acetique respectivement. Les feves saines sont steriles jusqu’a l’ouverture de la cabosse. L’inoculation des feves est realisee le plus souvent naturellement a l’aide de l’environnement autour de l’ecabossage et de la mise en fermentation. Les procedes de traitements post-recolte sont differents d’un pays a l’autre et influencent le deroulement de la fermentation. Cependant, trois especes de bacteries lactiques et acetiques (Lactobacillus plantarum, Lactobacillus fermentum et Acetobacter pasteurianus) dominent les fermentations dans tous les pays. Par contre, leur diversite intra specifique n’a ete que rarement etudiee. Dans cette etude nous avons utilise des methodes moleculaires independantes de la culture (PCR-DGGE et metabarcoding) pour etudier les communautes bacteriennes associees a la fermentation des feves de cacao selon trois pays : le Mexique, la Cote d’Ivoire et la Guyane. La methode de metabarcoding a egalement ete utilisee pour identifier la contribution des surfaces liees a l’environnement pre et post recolte des cabosses de cacao lors d’une fermentation realisee au Mexique. La dominance des genres Lactobacillus et Acetobacter au cours de la fermentation dans chaque pays a ete confirmee. De plus, la presence de genres specifiques a chaque pays a ete mise en evidence lors du premier jour de la fermentation. L’ensemble des surfaces lie a l’environnement de la fermentation semble participer a l’inoculation des genres dominants. Elles agissent en tant que reservoirs bacteriens. Une collection de souches de bacteries lactiques et acetiques a ete constituee. L. plantarum et A. pasteurianus ont ete les deux especes isolees en majorite. La diversite intra specifique des souches d’A. pasteurianus a ete etudiee. Pour cela, leurs polymorphismes genomiques ont ete analyses a l’aide d’une amplification par PCR sur des sequences repetees et leurs caracteristiques biochimiques ont ete comparees dans un milieu simulant les conditions de la pulpe de cacao au 2eme jour de fermentation. Notre etude a contribue a montrer que les memes souches d’A. pasteurianus peuvent etre presentes dans les 3 pays differents. Certaines souches se distinguent pour leur plus grande affinite pour l’acide lactique que les autres, ce qui est interessant pour ameliorer la qualite organoleptique du cacao final. Les resultats sur la diversite intra specifique nous permettent de proposer des candidats potentiels pour l’elaboration de starters de culture pour la fermentation des feves de cacao
Solieria incurvata (Solieriaceae, Rhodophyta), a new species from Venezuela based on morpho-anatomical and molecular evidence

Abstract Solieria incurvata from Puerto Escondido, Estado Falcon, Venezuela, is described as a new species based on morpho-anatomical and molecular data. Morphologically S. incurvata differs from other Solieria species, with which it shares its distributional range, by its narrow branches that become gradually constricted toward their bases, by possessing acute and incurved apices, and by its branching pattern and anatomical morphometrics. On the basis of COI-5P and rbcL sequences, the new species forms an independent lineage that clearly belongs in the Solieria clade of the Solieriaceae.
A case of epimeletic behavior and associated acoustic records of Indo-Pacific humpback dolphins (Sousa chinensis)

Several cetacean species have demonstrated epimeletic behavior that relies on the tight social bonds between conspecifics. These behaviors and the corresponding vocalizations were recorded during a rare encounter with a group of Indo-Pacific humpback dolphins (Sousa chinensis) that included a presumed mother and deceased calf, in Sanniang Bay, China. The observed dolphins were divided into 2 apparent groups: 1) a central group with the presumed mother and her deceased calf, along with 1 to 6 other individuals swimming in synchrony with the presumed mother; and 2) a following group of several individuals, dispersed over varying distances from approximately 20 to > 300 m, that swam in the same direction as the central group. The mother was seen mostly supporting the calf's body using her back, anterior to the dorsal fin and posterior to the melon, while the other members of the central group exhibited standing-by behaviors (i.e., remaining close to the deceased calf but not providing aid). Whistles in this context were of a longer duration and a higher complexity in the frequency modulation compared to social contexts. Several whistle types were also repeated frequently. This paper provides a detailed description of epimeletic behavior and the whistles possibly associated with that behavior in an endangered population of Indo-Pacific humpback dolphins.
Psychiatric Rehabilitation and Its Application to theAfrican Context; an Overview

Several authors have defined psychiatric disability their own way. Accepted definitions incorporated the following points: the presence in a person of a diagnosed mental disorder, and the mental disorder limits capacity of the individual to perform expected tasks and to function in terms of important social interactions. Studies compellingly indicate that severe mental illness can impair social and inter-personal functioning. Psychiatric rehabilitation is a process of facilitating recovery and full community integration, as well as improve quality of life of persons who have a diagnosed mental disorder. Psychiatric rehabilitation services enable the rehabilitation process by helping individuals acquire skills and access community resources. The core principles of psychiatric rehabilitation remain the same while the approaches can differ. In low and middle-income countries including Sub-Saharan Africa, there is a need to develop rehabilitation services which minimize cost and exploit the family and social structure advantages available in the community. There are some examples of unique and innovative approaches of psychiatric rehabilitation piloted in Africa, and some are discussed in this article. However, there is paucity of studies in the adaptation of psychiatric rehabilitation for use in such countries. Efforts should be geared towards further developing innovative approaches of psychiatric rehabilitation for use in the continent of Africa.
Technology Adoption Factors and Demographic Factors Related to the Behavior of the Mobile Banking Service to Pay for Online Purchases

The purpose of this Independent Study was to study of Technology acceptance in 2 topics including Perceived Usefulness and Perceived Ease of Use, and Demography factors affect to Mobile application actual use. The sample group used in the research was General public aged 18-60 years, both male and female were having behavior that used to buy products online and live in the Bangkok area of 400 people. The questionnaires as a tool in Data collection of the statistics used for data analysis are Frequency, Mean, Percentage and Standard Deviation and Pearson Correlation was used to test the relationship between variables in each hypothesis. T-test and One-Way ANOVA were used to test the sub-hypothesis. The result of the study found that the majority of the respondents are aged between 21-29 years, in bachelor's degrees ,and most majority income around 10,000-26,000. Technology Acceptance factors found out in Perceived Usefulness shown customers agree with the opinion that Mobile Banking helping customers easier and more convenience than usual. Based on the data analysis results for testing, the research hypothesis showed the benefits of the use of Mobile Banking, a factor of ease of use to Mobile Banking and education. Users who use a lower degree of Mobile Banking, compared to a higher degree of Mobile Banking Services, are based on statistically significant predicted assumptions at confidence level of 95%.
Evaluasi Perplexity Untuk Pemodelan Topik Diskusi Agama Islam Di Media Sosial Twitter Indonesia Tahun 2006-2018 Menggunakan Latent Dirichlet Allocation

vii KATA PENGANTAR . viii DAFTAR ISI . x DAFTAR GAMBAR . xii BAB I PENDAHULUAN . 1 1.1. Latar Belakang . 1 1.2. Rumusan Masalah . 3 1.3. Batasan Masalah . 3 1.4. Tujuan Penelitian . 4 1.5. Manfaat Penelitian . 4 BAB II TINJAUAN PUSTAKA DAN LANDASAN TEORI . 5 2.1. Islam, Hadits, dan Al-Qur’an . 5 2.2. Topic Modelling . 6 2.3. Evaluasi Topic Modelling . 6 2.4. Part-of-Speech Tagging . 8 2.4. Vector Space Model . 9 BAB III METODOLOGI PENELITIAN . 10
DEVELOPMENT OF LEARNING STRATEGY RECOMMENDATION SYSTEM TO TRAIN METACOGNITION AND SELF-REGULATED LEARNING IN ALGORITHM AND DATA STRUCTURE COURSE

Metacognitive training system (MTS) which is developed for Algorithm and Data Structure course facilitates students to choose, use, and evaluate different learning strategies. Therefore, students are encouraged to be self-regulated. However, the system is also expected to know the best learning strategies of students to generate recommendation that will help students to better understand their self. The recommendation is generated by using various parameters such as post-test scores, learning strategy evaluation values, learning strategy access time, number of clicks and number of summary words to determine the best level of metacognition and learning strategies for students. The learning strategy recommendation system developed using Simple Additive Fuzzy Weighting Algorithm. This method adds the weight of each criterion in each learning strategy. The system’s functionality is tested using Black Box method as well as validated by experts. A user acceptance test (UAT) is also carried out to prove that the system is accepted by users and requirements have been met. The UAT resulted in an average of 82.5% which is considered as very good.
Nuclear Tau modulates VGluT1 expression: a new function for Tau

Summary Tau displacement from microtubules is the first step in the onset of tauopathies, and is followed by toxic protein aggregation. However, other non-canonical functions of Tau might have a role in these pathologies. Here, we demonstrate that a small amount of Tau localizes in the nuclear compartment and accumulates in both the soluble and DNA-bound fractions. We show that nuclear Tau regulates the expression of VGluT1, a disease-relevant gene directly involved in glutamatergic synaptic transmission. Impeding Tau/tubulin interaction in the cytosol favours its nuclear translocation and increases VGluT1 expression. Remarkably, the P301L mutation impairs this mechanism leading to a loss of function. Altogether, our results provide the demonstration of a direct physiological role of Tau on gene expression. Alterations of this mechanism may be at the basis of the onset of neurodegeneration.
Identification of Novel Hits Against

Leishmaniasis is a disease caused by obligate intracellular parasites of the genus Leishmania. The genus includes 20 species that are pathogenic to humans. Female sand fly is the known vector that can transmit the disease. Leishmania donovani is the causative agent of visceral leishmaniasis. Visceral leishmaniasis is the severe form of the disease that affects internal organs and can be fatal with inappropriate diagnosis or treatment. Other forms of the disease include cutaneous and mucocutaneus. Approximately 350 million in 89 countries are at risk of infection. Around 2 million new cases are reported annually, of which 500,000 present in the visceral form. Current drug therapies are inadequate due to their toxicity, high cost, severe adverse reaction, limited availability, and the emergence of resistance. With all these limitations, the need for new drugs is urgent. Pentavalent antimonials have been the first line of treatment for leishmaniasis since the 1940s. Although amphotericin B, pentamidine and paromomycin are current drugs that treat leishmaniasis, they were discovered initially as a treatment for other pathogens. Miltefosine, the only available oral drug for leishmaniasis, is an anticancer drug that was found to be active against Leishmania. This project investigated new antileishmanial hits from unstudied or understudied natural products using quantitative Leishmania donovani axenic amastigote assay and the clinically relevant infected