Miracle-dz/UniFAR-FTUs huggingface dataset:
Exercise Is More Effective than Diet Control in Preventing High Fat Diet-induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice*♦

Background: Exercise and diet control are fundamental approaches to metabolic conditions caused by high fat diet (HFD). Results: HFD-induced memory deficit and Aβ deposition were more ameliorated in the exercise- than in the diet control-induced mice. Conclusion: Exercise was more effective than diet control in preventing HFD-induced AD development. Significance: Exercise has the highest priority in the prevention of AD. Accumulating evidence suggests that some dietary patterns, specifically high fat diet (HFD), increase the risk of developing sporadic Alzheimer disease (AD). Thus, interventions targeting HFD-induced metabolic dysfunctions may be effective in preventing the development of AD. We previously demonstrated that amyloid precursor protein (APP)-overexpressing transgenic mice fed HFD showed worsening of cognitive function when compared with control APP mice on normal diet. Moreover, we reported that voluntary exercise ameliorates HFD-induced memory impairment and β-amyloid (Aβ) deposition. In the present study, we conducted diet control to ameliorate the metabolic abnormality caused by HFD on APP transgenic mice and compared the effect of diet control on cognitive function with that of voluntary exercise as well as that of combined (diet control plus exercise) treatment. Surprisingly, we found that exercise was more effective than diet control, although both exercise and diet control ameliorated HFD-induced memory deficit and Aβ deposition. The production of Aβ was not different between the exercise- and the diet control-treated mice. On the other hand, exercise specifically strengthened the activity of neprilysin, the Aβ-degrading enzyme, the level of which was significantly correlated with that of deposited Aβ in our mice. Notably, the effect of the combination treatment (exercise and diet control) on memory and amyloid pathology was not significantly different from that of exercise alone. These studies provide solid evidence that exercise is a useful intervention to rescue HFD-induced aggravation of cognitive decline in transgenic model mice of AD.
Points-to analysis for C and Java

The main difference of this analysis from its predecessors is its running time. Andersen’s analysis [1], also flow-insensitive and monovariant, is cubic. Polyvariant analyses [2, 4] are more precise but have exponential complexity, though in practice this rarely happens. The linear running time allows us to make a simple observation about the analysis precision: the points-to graph must be linear in the size of the program. Thus, the out-degree of each node must be bounded by a constant. Therefore, all locations pointed to by the same location must be merged in one node in the graph, to avoid a quadratic number of edges.
Grid-based Supervised Clustering - GBSC

This paper presents a supervised clustering algorithm, namely Grid-Based Supervised Clustering (GBSC), which is able to identify clusters of any shapes and sizes without presuming any canonical form for data distribution. The GBSC needs no prespecified number of clusters, is insensitive to the order of the input data objects, and is capable of handling outliers. Built on the combination of grid-based clustering and density-based clustering, under the assistance of the downward closure property of density used in bottom-up subspace clustering, the GBSC can notably reduce its search space to avoid the memory confinement situation during its execution. On two-dimension synthetic datasets, the GBSC can identify clusters with different shapes and sizes correctly. The GBSC also outperforms other five supervised clustering algorithms when the experiments are performed on some UCI datasets. Keywords—supervised clustering, grid-based clustering, subspace clustering
Concise Tour to the Virtual Old Prague

This paper describes a structure and a user interface of the Internet based 3D presentation of existing historical part of city Prague. The application offers a smooth tour to selected regions of the real city, utilizing number of standard and modern technologies including VRML, Java, and PHP. The architecture of the whole virtual model is presented together with several advanced and specific features like dynamic loading und unloading objects or newly proposed LOD for urban scenes. This running web application seems to be currently unique in terms of complexity, functionality, and scaleability for further growth. The paper introduces methodology suitable for immediate creation of arbitrary virtual city according to a real one.
Mean BoF per Quadrant - Simple and Effective Way to Embed Spatial Information in Bag of Features

This paper proposes a new approach for embedding spatial information into a Bag of Features image descriptor, primarily meant for image retrieval. The method is conceptually related to Spatial Pyramids but instead of requiring fixed and arbitrary sub-regions where to compute region-based BoF, it relies on an adaptive procedure based on multiple partitioning of the image in four quadrants (the NE, NW, SE, SW regions of the image). To obtain a compact and efficient description, all BoF related to the same quadrant are averaged, obtaining four descriptors which capture the dominant structures of the main areas of the image, and then concatenated. The computational cost of the method is the same as BoF and the size of the descriptor comparable to BoF, but the amount of spatial information retained is considerable, as shown in the experimental analysis carried
Thermal and Optical Properties of Epoxy/Siloxane Hybrimer Based on Sol-Gel-Derived Phenyl-Siloxane

A hybrimer based on epoxy resin and phenyl-siloxane was prepared by polymerization and a solgel condensation reaction in which Eporite-904 (807 g/eq) bisphenol-A-type epoxy resin, 3-isocyanatopropyltriethoxysilane (IPTES) and phenyltriethoxysilane (PTEOS) acted as precursors. The thermal and optical properties of the epoxy/siloxane hybrimer were studied. The thermogravimetric analysis (TGA) results implied that the hybrimer could increase the crosslink density and enhance the thermal properties. The optical properties were measured after thermal and UV aging. The refractive indexes of the epoxy/siloxane hybrimers were 1.66 - 1.70, and the transmittances of the cured hybrimers were above 90% in the visible wavelength. After a 120°C/24-h thermal aging test, the decreases in the refractive index and transmittance were less than 5% and 20% respectively. The epoxy/siloxane hybrimers also showed low discoloration upon thermal aging at 120°C for 24 h under an air atmosphere.
HPV16 E6 variants: Frequency, association with HPV types and in silico analysis of the identified novel variants

High‐risk human papillomavirus (HPV) types, specifically HPV 16 E6 variants are involved in viral persistence and the development of cervical lesions. India contributes to 1/3rd of the global cervical cancer deaths; however, information on E6 variants in the Indian population is limited. Information on these variants is essential for successful implementation of cervical cancer immunization programs. The E6 variants and their possible biological implications to the outcome of infection were studied in women attending the Tata Memorial Hospital, Mumbai, India. Cervical cancer patients with HPV 16 as a single infection (n = 33), co‐infection with another HPV type (n = 20) or with multiple types (n = 10) were examined for HPV16 E6 variants using PCR and sequence analysis. The variants were identified using the prototype sequence (HPV 16R) belonging to the European lineage. The results revealed that the European T350G was the most common variant (50%) followed by the European prototype (40.3%) and the North‐American (N = 3; 4.8%). The European prototype was significantly more frequent in patients infected with HPV16 alone (P < 0.05, C.I. 1.2–13.6), while the European T350G variants were seen in women with co‐infections. The North‐American lineage was found in women infected with HPV16 and 33. Three novel variants were identified of which two were non‐synonymous. Phylogenetic analysis revealed that the variant F69L + L83V is not related to any of these lineages, while the variant M137L + L83V is closely related to the North American variant. This study found a difference in the prevalence of E6 variants compared to earlier Indian studies and their association with type of infection. J. Med. Virol. 86:968–974, 2014. © 2014 Wiley Periodicals, Inc.
Solid-State Dual Marx Generator With a Short Pulsewidth

A solid-state Marx generator with a short pulsewidth not restrained by the maximum operating frequency of the employed semiconductor switches is proposed for adapting to various pulsed power applications. This repetitive generator is capable of controlling the voltage level, polarity, pulsewidth, and frequency for each pulse. The proposed topology is based on a fully solid-state Marx concept using a series connection of full-bridge switch-capacitor cells (SCCs). Independent control and combination of each SCCs' operation mode result in a greater freedom of control of the pulse parameter. An eight-SCCs stage prototype was implemented using 1200 V insulated gate bipolar transistors and tested. In the experiments, the bipolar pulses of from -4 to 4-kV amplitude are achieved, and the pulsewidth was adjusted down to 300 ns.
Radiochromatographic identification of thyroxin in an alpha globulin fraction of serum separated by starch zone electrophoresis.

Iodine administered orally as NaI131 associates with two electrophoretically identifiable serum proteins (1-4). It appears first with the albumin fraction where it is associated with the slower moving component. It is later found in a zone of low protein concentration just ahead of alpha-2 globulin. This behavior was observed in the serum from both euthyroid and hyperthyroid subjects. However, in hyperthyroid subjects the tracer iodine concentrated faster, attained higher levels, and declined more rapidly in this alpha globulin zone (5). This suggested that the hormonal iodine may be associated with this specific protein. The exact nature of this iodine compound is unsettled although the presence of thyroxin and more recently 3:5:3'-L-triiodothyronine (6) has been demonstrated in whole serum. The purpose of this present paper is to report the radiochromatographic analysis of iodine containing amino acids associated with an alpha globulin fraction separated by starch electrophoresis.
[The construction of three-dimensional visualization platform and its application in diagnosis and treatment for hilar cholangiocarcinoma].

OBJECTIVE To explore the construction and clinical efficacy of three-dimensional(3D) visualization platform about diagnosis and treatment of hilar cholangiocarcinoma. METHODS From January 2009 to December 2015, a total of 32 patients with hilarcholangiocarcinoma treated in Zhujiang Hospital of Southern Medical University were analyzed.There were 20 male and 12 female patients aged from 40 to 85 years. Bismuth-Corlette 3D visualization type: 2 cases with type Ⅰ, 5 cases with type Ⅱ, 10 cases with type Ⅲa, 11 cases with type Ⅲb, 4 cases with type Ⅳ. Among 32 cases, there were 5 cases who were established liver 3D printing models to guide intraoperative real-time navigation.The clinical effect of this platform was evaluated by the operation time, intraoperative blood loss, laboratory test and postoperative complications.The 3D visualization platform consists of the preoperative surgical planning with the aid of virtual 3D reconstruction technology and intraoperative real-time navigation with 3D printing models. RESULTS The liver 3D models for all patients were constructed successfully, they could clearly show intrahepatic pipeline, size and location of tumors, relationship between tumor and intrahepatic pipeline.The 3D printing models could accomplish real-time intraoperative navigation surgery with strong stereoscopic sense.According to Bismuth classification 3D visualization type, 2 patients with type Ⅰ received local excision of tumor and choledochojejunostomy; 5 patients with type Ⅱ received resection of segment Ⅰ, Ⅳb and partial Ⅴ combined with choledochojejunostomy; 10 patients with type Ⅲa received right semi-hepatectomy combined with resection of segment Ⅰ and choledochojejunostomy; 11 cases with type Ⅲb received left semi-hepatectomy combined with resection of segment Ⅰ and choledochojejunostomy; 4 cases with type Ⅳ received resection of segment Ⅳb and Ⅴ combined with choledochojejunostomy.The operation time was 270-660 minutes; the mean intraoperative blood loss was 588 ml; the mean postoperative hospital stay was 25 days.The bilirubin level three day after operation was 233 μmol/L.There was 1 case presented biliary fistula and cured by conservative treatment; there was no incision infection, no liver failure and no perioperative deaths occurred. CONCLUSION The 3D visualization is valuable for optimizing the operation scheme preoperatively and navigating surgery accurately intraoperatively in real-time which may improve the precision of the operation and achieve better the recovery.
Strategies for Interweaving Groupware and Organizational Structure

Many authors contend that realizing benefits of new information technologies requires adjusting such technologies to fit with the organization’s context or, alternatively, they suggest adjusting organizational practices to accord with the new technologies (Rifkin, 1995). However, Orlikowski and Yates (2006) pointed out that the ways these prescriptions are applied in practice are yet ill defined. Our research yields practice-based suggestions for developing groupware, organizational processes, procedures, and organizational culture needed for successful implementation of information technology.
Eugenics--sacred and profane.

It begins innocuously enough. A six-month-old baby, once thriving and cheerful, begins reacting differently to normal sounds such as clapping hands or closing doors. Her parents notice that her limbs twitch and her muscles are not developing properly. She has trouble swallowing and shows signs of mental retardation. What they can't see is her compromised brain tissue, which began degenerating when she was still in her mother s womb. Soon their once-healthy child is in the grips of an overwhelming illness. As the deterioration intensifies, fatty deposits overwhelm the nerve cells in her brain, and she experiences seizures and paralysis. Bright cherry red spots appear on the retinas of her eyes, and she is rendered blind. Their daughter lapses into a vegetative state, and by the age of 3 or 4, she is dead, often of complications from pneumonia. If ever there was a clear case for using our knowledge of human genetics to end suffering, Tay-Sachs, a killer of children, is it. There is no cure for the disease. A single-gene disorder, Tay-Sachs is named for British ophthalmologist Warren Tay, who first described the cherry-red spot on Tay-Sachs victims' eyes in 1881, and for Bernard Sachs, a neurologist in New York who outlined the other progressive degenerations of the disease and noted the frequency of its occurrence among Ashkenazi Jews (Jews of Central and Eastern European descent). The rate of Tay-Sachs disease among Ashkenazi Jews is approximately 1 in every 3,000 births nearly 100 times higher than other ethnic groups. Tay-Sachs is inherited in an autosomal recessive fashion, which means that both parents must be carriers of the defective gene to have an afflicted child. If both parents are carriers, they have a one in four chance for each pregnancy of having a child with Tay-Sachs. Not long ago, information about a particular ethnic groups unique genetic characteristics was hardly so precise. Certain diseases and disorders appeared more frequently in particular populations: People of Mediterranean descent suffer from the group of blood disorders known as thalassemia; those of African descent experience higher rates of sickle cell anemia; and whites of Northern European descent are more likely to have children with cystic fibrosis. But it is only recently that we have gained the power to pinpoint the genes that cause these specific conditions, among ethnic groups and in individuals. As a result, our attention has moved beyond preventing germ-borne disease at the macro level such as last century's crusades to eradicate diseases like
Upf1p Control of Nonsense mRNA Translation Is Regulated by Nmd2p and Upf3p

ABSTRACT Upf1p, Nmd2p, and Upf3p regulate the degradation of yeast mRNAs that contain premature translation termination codons. These proteins also appear to regulate the fidelity of termination, allowing translational suppression in their absence. Here, we have devised a novel quantitative assay for translational suppression, based on a nonsense allele of the CAN1 gene (can1-100), and used it to determine the regulatory roles of theUPF/NMD gene products. Deletion of UPF1,NMD2, or UPF3 stabilized thecan1-100 transcript and promoted can1-100nonsense suppression. Changes in mRNA levels were not the basis of suppression, however, since deletion of DCP1 orXRN1 or high-copy-number can1-100 expression in wild-type cells caused an increase in mRNA abundance similar to that obtained in upf/nmd cells but did not result in comparable suppression. can1-100 suppression was highest in cells harboring a deletion of UPF1, and overexpression ofUPF1 in cells with individual or multipleupf/nmd mutations lowered the level of nonsense suppression without affecting the abundance of the can1-100 mRNA. Our findings indicate that Nmd2p and Upf3p regulate Upf1p activity and that Upf1p plays a critical role in promoting termination fidelity that is independent of its role in regulating mRNA decay. Consistent with these relationships, Upf1p, Nmd2p, and Upf3p were shown to be present at 1,600, 160, and 80 molecules per cell, levels that underscored the importance of Upf1p but minimized the likelihood that these proteins were associated with all ribosomes or that they functioned as a stoichiometric complex.
Phase biases for ambiguity resolution : from an undifferenced to an uncombined formulation

Integer ambiguity fixing has been recently applied to undifferenced GPS phase measurements to achieve precise positioning or PPP-AR. This technique relies on the estimation of specific phase biases combination identification and application. It works for dual-frequency GPS receivers. However, this phase biases representation is not suitable for triple frequency receivers, as the number of possible combinations for the biases can be dramatically high. This paper presents a new uncombined formulation for phase biases, as proposed in the RTCM SSR standardization framework. The validity of such a representation for triple frequency receivers is demonstrated. In order to validate the proposed model, a technique to compute such phase biases is presented. Using real measurements, we show that the integer ambiguity nature of phase measurement is valid under the new uncombined formulation at least for all the ionosphere free combinations whose noise is small enough. 1) INTRODUCTION Integer ambiguity fixing is now routinely applied to undifferenced GPS phase measurements to achieve precise positioning. Some implementations are also available in real-time [5]. This implementation allows performing PPP with ambiguity resolution at the cm level. With the new modernized satellites capabilities, performing PPP with triple frequency measurements will be possible and therefore, the current dual-frequency formulation will not be applicable. There is also a need for a generalized formulation of phase biases for RTCM. In this RTCM framework, the definition of a standard is important to allow interoperability between the two components of a positioning system, i.e. the network side and the user one.
Erector Spinae Muscle Changes on Magnetic Resonance Imaging Following Lumbar Surgery Through a Posterior Approach

Study Design. Prospective randomized study of patients undergoing lumbar arthrodesis. Objectives. To quantify MRI changes of the erector spinae following lumbar surgery through a posterior approach and the possible protection of these muscles during surgery by the use of cholinergic blockade. Summary of Background Data. It has been shown that lumbar spine surgery through a posterior approach can induce iatrogenic lesions in the erector spinae. We have shown in a previous study that histologic changes on muscular biopsy performed in the multifidus at the end of the surgical procedure were not modified by the use of cholinergic blockade during surgery. Methods. Twenty patients scheduled to undergo pedicle-screw enhanced L4–L5 arthrodesis were enrolled in this study. Ten patients received curare during anesthesia and 10 patients did not. MRI was obtained the day before the operation and at 6 months of follow-up on the same MR scanner. T1-weighted images were obtained in the axial plane. The 2 slices immediately proximal and distal to the pedicle screw construct on the postoperative MRI were selected. The corresponding slices were selected on the preoperative MRI. Each erector spinae on the 4 slices was surrounded using a mouse-guided tool. The contractile component of the cross-sectional area (CCSA) was calculated from the number of pixels surrounded and the signal intensity of each pixel. Results. There was only slight changes in the erector spinae CCSA proximal to a posterior lumbar arthrodesis. Erector spinae CCSA decreased by 27% distal to the arthrodesis. Curare showed no efficacy in preventing muscle damage. Conclusions. Erector spinae muscle alterations mainly occur distal to posterior lumbar surgical procedures.
Estudio de aspectos dinámicos en sistemas orientados al objeto

EN ESTA TESIS SE HAN ESTUDIADO LOS COMPONENTES PRINCIPALES DE SISTEMAS ORIENTADOS AL OBJETO EN MODELADO CONCEPTUAL, LA TECNICA UTILIZADA PARA LA DESCRIPCION DE ESTAS CONSTRUCCIONES HA SIDO EL CALCULO-PI Y HO-PI.
Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B.

PURPOSE Patients with high-risk myelodysplastic syndrome (MDS) have high mortality from bone marrow failure or transformation to acute leukemia. Supportive care is standard therapy. We previously reported that azacitidine (Aza C) was active in patients with high-risk MDS. PATIENTS AND METHODS A randomized controlled trial was undertaken in 191 patients with MDS to compare Aza C (75 mg/m(2)/d subcutaneously for 7 days every 28 days) with supportive care. MDS was defined by French-American-British criteria. New rigorous response criteria were applied. Both arms received transfusions and antibiotics as required. Patients in the supportive care arm whose disease worsened were permitted to cross over to Aza C. RESULTS Responses occurred in 60% of patients on the Aza C arm (7% complete response, 16% partial response, 37% improved) compared with 5% (improved) receiving supportive care (P <.001). Median time to leukemic transformation or death was 21 months for Aza C versus 13 months for supportive care (P =.007). Transformation to acute myelogenous leukemia occurred as the first event in 15% of patients on the Aza C arm and in 38% receiving supportive care (P =.001). Eliminating the confounding effect of early cross-over to Aza C, a landmark analysis after 6 months showed median survival of an additional 18 months for Aza C and 11 months for supportive care (P =.03). Quality-of-life assessment found significant major advantages in physical function, symptoms, and psychological state for patients initially randomized to Aza C. CONCLUSION Aza C treatment results in significantly higher response rates, improved quality of life, reduced risk of leukemic transformation, and improved survival compared with supportive care. Aza C provides a new treatment option that is superior to supportive care for patients with the MDS subtypes and specific entry criteria treated in this study.