Miracle-dz/UniFAR-FTUs huggingface dataset:
Left ventricular hypertrophy and geometric remodeling in hypertension: stimuli, functional consequences and prognostic implications.

OBJECTIVE To provide a coherent overview of the stimuli to development of abnormal left ventricular geometric patterns, their impact on cardiac function and their relationship to the prognosis of hypertension, studies performed by the authors and other investigators are reviewed. RESULTS Clinical and experimental studies have shown that an elevated left ventricular mass reflects the additive effects on the heart of higher arterial pressure over time, increased cardiac volume load related to obesity, sodium intake or other stimuli, reduced contractile efficiency of the myocardium and altered arterial hemodynamics related to vascular hypertrophy and atherosclerosis. The heart may adapt to hypertension by developing concentric or eccentric left ventricular hypertrophy, or the newly described pattern of concentric left ventricular remodeling, or by retaining normal left ventricular geometry. Each geometric pattern is associated with a distinct combination of pressure and volume stimuli, contractile efficiency (reduced in those with concentric left ventricular hypertrophy or remodeling) and prognosis (worst with concentric hypertrophy and best with normal left ventricular geometry). An appraisal of left ventricular mechanics by a physiologically appropriate midwall-shortening/end-systolic stress relationship can identify impaired contractility in an appreciable proportion of hypertensive patients. Numerous studies have shown that increased left ventricular mass and abnormal geometry have a strong predictive value for cardiovascular death, myocardial infarction and stroke. CONCLUSIONS Increasing evidence has demonstrated the central importance of left ventricular mass and geometry in the pathophysiology and prognosis of hypertension. These measures of preclinical disease can aid clinical decision-making by separating patients into those with a high or a relatively low risk, and hence a need for pharmacological treatment or its intensification, as well as providing useful bioassays for a spectrum of clinical and experimental research.
Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1*

The Saccharomyces cerevisiae Sir2 protein is an NAD+-dependent histone deacetylase that plays a critical role in transcriptional silencing, genome stability, and longevity. A human homologue of Sir2, SIRT1, regulates the activity of the p53 tumor suppressor and inhibits apoptosis. The Sir2 deacetylation reaction generates two products:O-acetyl-ADP-ribose and nicotinamide, a precursor of nicotinic acid and a form of niacin/vitamin B3. We show here that nicotinamide strongly inhibits yeast silencing, increases rDNA recombination, and shortens replicative life span to that of asir2 mutant. Nicotinamide abolishes silencing and leads to an eventual delocalization of Sir2 even in G1-arrested cells, demonstrating that silent heterochromatin requires continual Sir2 activity. We show that physiological concentrations of nicotinamide noncompetitively inhibit both Sir2 and SIRT1 in vitro. The degree of inhibition by nicotinamide (IC50< 50 μm) is equal to or better than the most effective known synthetic inhibitors of this class of proteins. We propose a model whereby nicotinamide inhibits deacetylation by binding to a conserved pocket adjacent to NAD+, thereby blocking NAD+ hydrolysis. We discuss the possibility that nicotinamide is a physiologically relevant regulator of Sir2 enzymes.
Studies of the Mortality of A-Bomb Survivors: I. Plan of Study and Mortality in the Medical Subsample (Selection I), 1950-1958

Part of a life-span study, designed to evaluate the late mortality effects of radiation and other trauma received by the survivors of the Hiroshima and Nagasaki A-bombs, is reported. About l00,000 persons, including those exposed near to ground zero, persons exposed at such distances from ground zero as to guarantee that little radiation was received, and nonexposed immigrants to the cities, were studied. Mortality data for a subsample of 20,000 persons are given. The data were analyzed with respect to death rates from all causes and from certain major causes and groups of causes. No evidence of higher general mortality was found in the more heavily irradiated groups. WWhen mortality from specific causes was studied, the well-known leukemogenic properties of radiation were clearly reflected, but radiation effects were not seen for other causes. An apparent effect in the area of anemia seems, at least in large part, to result from diagnostic difficulties in the blood dyscrasias, since some leukemias were so classified. (P.C.H.)
MAP – A database to RDF mapping language

bizer@wiwiss.fu-berlin.de ABSTRACT The vision of the Semantic Web is to give data on the web a welldefined meaning by representing it in RDF and linking it to commonly accepted ontologies. Most formatted data today is stored in relational databases. To be able to use this data on the Semantic Web we need a flexible but easy to use mechanism to map relational data to RDF. The poster presents D2R MAP, a declarative language to describe mappings between relational database schemata and OWL ontologies.
EBAG 9 Adds a New Layer of Control on Large Dense-Core Vesicle Exocytosis via Interaction with Snapin □ D

*Department of Hematology, Oncology, and Tumor Immunology, Max-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany; †Abteilung Membranbiophysik, Max-Planck-Institut für Biophysikalische Chemie, 37077 Göttingen, Germany; ‡Department of Pharmacology, Universitätsklinikum Benjamin-Franklin, 12200 Berlin, Germany; and Department of Hematology, Oncology, and Tumor Immunology, Robert-RössleKlinik, Universitätsmedizin Berlin, Charite, 12200 Berlin, Germany
Non-Fully Symmetric Space-Time Matérn Covariance Functions

The problem of nonseparable space-time covariance functions is essential and difficult in spatiotemporal data analysis. Considering that a fully symmetric space-time covariance function is inappropriate for many spatiotemporal processes, this article provides a way to construct a non-fully symmetric nonseparable space-time correlation function from any given marginal spatial Matérn and marginal temporal Matérn correlation functions. Using the relationship between a spatial Matérn correlation function and the characteristic function of a multivariate t-distribution, a modification of Bochner’s representation is provided and a non-fully symmetric space-time Matérn model is obtained.
Comparison of population structure in Ohio's late archaic and late prehistoric periods.

Previous studies of population structure among prehistoric groups in the Ohio valley region have shown that hunting-gathering populations exhibited a different structure than horticultural populations. Among both Late Archaic hunter-gatherers and Late Prehistoric horticulturists, covariance structures for cranial metrics were found to be homogenous within the populations, but the Late Archaic subpopulations showed little differentiation while the Late Prehistoric subpopulations exhibited a marked differentiation. Biodistance based on cranial discrete trait frequency showed similar patterns, but in the Late Archaic discrete trait distance was associated significantly with the geographical distance separating populations. The present investigation is an extension of the previous studies increasing the Late Prehistoric sample (n = 8 samples and n = 341 individuals) and using the Harpending-Ward model, modified for use with multivariate quantitative data, to estimate the effects of differential gene flow and the amount of differentiation within populations. Results of the present analyses indicate that differentiation among subpopulations, measured by minimum F(ST), was greater in the Late Prehistoric compared to the Late Archaic period. However, for both periods the minimum F(ST) is comparable to values found for historic native populations of the northeast woodlands. Analysis of differential gene flow in the Late Archaic period indicates that geographically peripheral populations were affected more by external gene flow than more central populations. Late Prehistoric populations exhibit a very complex pattern of differential gene flow. We discuss the latter pattern in terms of proposed culture change in the Late Prehistoric period of Ohio.
Visual Responsiveness of Neurons in the Secondary Somatosensory Area and its Surrounding Parietal Operculum Regions in Awake Macaque Monkeys

Previous neurophysiological studies performed in macaque monkeys have shown that the secondary somatosensory cortex (SII) is essentially engaged in the processing of somatosensory information and no other sensory input has been reported. In contrast, recent human brain-imaging studies have revealed the effects of visual and auditory stimuli on SII activity, which suggest multisensory integration in the human SII. To determine whether multisensory responses of the SII also exist in nonhuman primates, we recorded single-unit activity in response to visual and auditory stimuli from the SII and surrounding regions in 8 hemispheres from 6 awake monkeys. Among 1157 recorded neurons, 306 neurons responded to visual stimuli. These visual neurons usually responded to rather complex stimuli, such as stimulation of the peripersonal space (40.5%), observation of human action (29.1%), and moving-object stimulation outside the monkey's reach (23.9%). We occasionally applied auditory stimuli to visual neurons and found 10 auditory-responsive neurons that exhibited somatosensory responses. The visual neurons were distributed continuously along the lateral sulcus covering the entire SII, along with other somatosensory neurons. These results highlight the need to investigate novel functional roles—other than somesthetic sensory processing—of the SII.
Differential space–time network coding in MIMO two‐way relay channel network

This paper focuses on noncoherent detection scheme for multiple‐input multiple‐output two‐way relay channel network with two two‐antennas source nodes and one single‐antenna relay node. An orthogonal differential space–time network coding (ODSTNC) scheme based on relay detection and forward protocol is proposed. The proposed scheme combines space–time coding with network coding, and the differential modulation and detection are used in both multiple access stage and broadcast stage. The multiple‐symbol differential detection is employed at the relay. The maximum likelihood decision and its low‐complexity sphere decoding decision are given. The upper and lower bounds on the average symbol error probability for this system under differential binary phase shift keying (DBPSK) are derived, and a diversity order of 2 is confirmed to be achieved. The simulation results show that the ODSTNC scheme has good performance, and it is available for the applications of far distance signal transmission between two terminals where channel state information is unknown. Copyright © 2014 John Wiley & Sons, Ltd.
Perception of dynamic horizontal image translation in stereo 3D content: An experimental study to identify cognitive factors

Dynamic horizontal image translation (HIT) denotes the act of slowly shifting stereo views horizontally in opposite directions in order to ensure that points of visual attention are located near the display plane. Thereby, visual discomfort is reduced. This technique is widespread, however, little is actually known about its visual perception by a human observer. Therefore, two experiments have been carried out to identify determining factors of cognition. The results of the subjective evaluations are presented in the course of this paper.
Unique role of CD4+CD62L+ regulatory T cells in the control of autoimmune diabetes in T cell receptor transgenic mice

Converging experimental evidence indicates that CD4+ regulatory T cells control progression of autoimmune insulitis in nonobese diabetic (NOD) mice. Here, we studied the nature of these regulatory T cells and their mode of action in diabetes-prone NOD Rag-/- or severe combined immunodeficient (SCID) mice harboring a transgenic T cell receptor derived from the diabetogenic T cell clone BDC2.5. We first show that diabetes onset is prevented in such mice by infusion of polyclonal CD4+ T cells expressing l-selectin (CD62L) but not prevented or only marginally prevented by CD4+CD25+ T cells. Similarly, we found with a cotransfer model that CD4+CD62L+ T cells but not CD4+CD25+ T cells inhibited diabetes transfer into NOD SCID recipients by transgenic NOD BDC2.5 SCID cells. Unexpectedly, cotransfer of transgenic NOD BDC2.5 SCID cells and spleen cells from WT diabetic NOD mice did not induce diabetes, whereas each individual population did so. Data are presented arguing for the role of CD4+CD62L+ T cells present within the polyclonal diabetogenic population in mediating this apparently paradoxical effect. Collectively, these data confirm the central role of CD4+CD62L+ regulatory T cells in controlling disease onset in a well defined transgenic model of autoimmune diabetes and suggest the intervention of homeostatic mechanisms as part of their mode of action.
Novel HARQ schemes for MIMO single-hop and Multi-hop relay systems

Multiple Input Multiple Output (MIMO) systems use multiple transmit and receive antennas to achieve higher data rates by transmitting multiple independent data systems. Transmission errors can be reduced by using Hybrid Automatic Repeat request (HARQ) combining techniques with MIMO systems. We propose two novel MIMO HARQ combining methods which are based on using pre-combining only and a joint post and pre-combining techniques. In addition to conventional direct transmission, HARQ schemes for MIMO Multi-hop relay systems are also investigated. A novel approach is proposed to deal with the parallel HARQ processes in MIMO relay scenario. The simulation results show that the proposed methods can enhance the overall throughput performance of MIMO Single-hop and multi-hop relay systems.
Similar adherence rates favor different virologic outcomes for patients treated with nonnucleoside analogues or protease inhibitors.

BACKGROUND This prospective study verified the effect of adherence on the risk of virologic failure. METHODS At enrollment in the study, a total of 543 patients who were following a steady (duration, >or=6 months) and effective (viral load, <50 human immunodeficiency virus [HIV] RNA copies/mL) regimen of highly active antiretroviral therapy (HAART) completed a self-reported questionnaire derived from the Adult AIDS Clinical Trials Group Adherence Follow-up Questionnaire. Patients were followed up for the subsequent 6 months to document virologic failure, which was defined as 2 consecutive viral load measurements of >500 HIV RNA copies/mL. RESULTS Only the type of treatment and the adherence rate at baseline were significantly associated with the virologic end point. Among patients who reported an adherence rate of <or=75%, the rate of virologic failure was 17.4%; this rate decreased to 12.2% for patients whose adherence rate was 76%-85%, to 4.3% for patients whose adherence rate was 86%-95%, and to 2.4% for patients whose adherence rate was >95%. When analysis was adjusted according to the type of regimen received, patients who were receiving protease inhibitor (PI)-based HAART and who had an adherence rate of up to 85% had a virologic failure rate of >20%, whereas, only for patients who were receiving nonnucleoside reverse-transcriptase inhibitor (NNRTI)-based HAART and who had an adherence rate of <or=75%, the virologic failure rate was >10%. For the comparison of NNRTI-treated patients and PI-treated patients with an adherence rate of 75%-95%, the odds ratio was 0.157 (95% confidence interval, 0.029-0.852). The number of pills and daily doses received correlated with the reported adherence rate. CONCLUSIONS Patients receiving NNRTIs report a higher rate of adherence than do patients receiving PIs. Adherence is significantly influenced by the number of pills and daily doses received. Low adherence is a major determinant of virologic failure; however, different therapies have different cutoff values for adherence that determine a significant increment of risk.
Bivariate method for spatio-temporal syndromic surveillance.

INTRODUCTION Statistical analysis of syndromic data has typically focused on univariate test statistics for spatial, temporal, or spatio-temporal surveillance. However, this approach does not take full advantage of the information available in the data. OBJECTIVES A bivariate method is proposed that uses both temporal and spatial data information. METHODS Using upper respiratory syndromic data from an eastern Massachusetts health-care provider, this paper illustrates a bivariate method and examines the power of this method to detect simulated clusters. RESULTS Use of the bivariate method increases detection power. CONCLUSIONS Syndromic surveillance systems should use all available information, including both spatial and temporal information.
Defining the enzyme binding domain of a ribonuclease III processing signal. Ethylation interference and hydroxyl radical footprinting using catalytically inactive RNase III mutants.

Ethylation interference and hydroxyl radical footprinting were used to identify substrate ribose‐phosphate backbone sites that interact with the Escherichia coli RNA processing enzyme, ribonuclease III. Two RNase III mutants were employed, which bind substrate in vitro similarly as wild‐type enzyme, but lack detectable phosphodiesterase activity. Specifically, altering glutamic acid at position 117 to lysine or alanine uncouples substrate binding from cleavage. The two substrates examined are based on the bacteriophage T7 R1.1 RNase III processing signal. One substrate, R1.1 RNA, undergoes accurate single cleavage at the canonical site, while a close variant, R1.1[WC‐L] RNA, undergoes coordinate double cleavage. The interference and footprinting patterns for each substrate (i) overlap, (ii) exhibit symmetry and (iii) extend approximately one helical turn in each direction from the RNase III cleavage sites. Divalent metal ions (Mg2+, Ca2+) significantly enhance substrate binding, and confer stronger protection from hydroxyl radicals, but do not significantly affect the interference pattern. The footprinting and interference patterns indicate that (i) RNase III contacts the sugar‐phosphate backbone; (ii) the RNase III‐substrate interaction spans two turns of the A‐form helix; and (iii) divalent metal ion does not play an essential role in binding specificity. These results rationalize the conserved two‐turn helix motif seen in most RNase III processing signals, and which is necessary for optimal processing reactivity. In addition, the specific differences in the footprint and interference patterns of the two substrates suggest why RNase III catalyzes the coordinate double cleavage of R1.1[WC‐L] RNA, and dsRNA in general, while catalyzing only single cleavage of R1.1 RNA and related substrates in which the scissle bond is within an asymmetric internal loop.
Leukopoietic activity in human urine. The granulocytic leukemias.

Abstract Urine from normal persons and patients with acute and chronic leukemia was tested for ability to stimulate granulocyte bone-marrow colony growth in vitro. All eight patients with chronic granulocytic leukemia had high levels of colonygrowth-stimulating activity. Six out of seven patients with acute stem-cell or acute lymphatic leukemia also had high levels, whereas nine out of 15 patients with untreated acute granulocytic leukemia had low or absent levels. In acute granulocytic leukemia, levels may rise during treatment, often becoming normal to very high with remission, only to fall again to subnormal levels with relapse.
Procedure for manipulator inverse kinematics computation and proper pseudoinverse perturbation

In this article, an efficient procedure for the proper pseudoinverse perturbation and the numerical inverse kinematics computation of robot manipulators is presented. The approach is based on solving a linear system of equations and using an original scheme for the appropriate perturbation of the pseudoinverse matrix in the next iteration. The resultant algorithm is tested on the simulation of an industrial robot manipulator. From the results obtained, it is observed that the proposed approach compares favorably with the approaches using a Gaussian elimination procedure and with pseudoinverse robustness based on a manipulability measure.
Mapping Parallels between Outdoor Urban Environments and Indoor Manufacturing Environments

The concepts of “Smart Cities” and “Smart Manufacturing” are different data-driven domains, although both rely on intelligent information technology and data analysis. With the application of linked data and affordance-based approaches, both domains converge, paving the way for new and innovative viewpoints regarding the comparison of urban tasks with indoor manufacturing tasks. The present study builds on the work, who state that cities are scaled versions of each other, by extending this thesis towards indoor manufacturing environments. Based on their structure and complexity, these environments are considered to form ecosystems of their own, comparable to “small cities”. This conceptual idea is demonstrated by examining the process of human problem-solving in transportation situations from both perspectives (i.e., city-level and manufacturing-level). In particular, the authors model tasks of human operators that are used to support transportation processes in indoor manufacturing environments based on affordances and spatial-temporal data. This paper introduces the fundamentals of the transformation process of outdoor tasks and process planning activities to indoor environments, particularly to semiconductor manufacturing environments. The idea is to examine the mapping of outdoor tasks and applications to indoor environments, and vice-versa, based on an example focusing on the autonomous transportation of production assets in a manufacturing environment. The approach is based on a spatial graph database, populated with an indoor navigation ontology and instances of indoor and outdoor objects. The results indicate that human problem-solving strategies can be applied to indoor manufacturing environments to support decision-making in autonomous transportation tasks.
Antidiabetic and Antioxidative Activities of Butyrolactone I from Aspergillus terreus MC751

Abstract— The bioassay-guided isolation and purification of an ethyl acetate extract of Aspergillus terreus MC751 led to the characterization of butyrolactone I as an antidiabetic and antioxidant. The antidiabetic activity of butyrolactone I was evaluated by α-glucosidase and α-amylase inhibition assays. Butyrolactone I demonstrated significant concentration-dependent, mixed-type inhibitory activity against yeast α-glucosidase with an IC 50 of 54μM. However, the compound exhibited less activity against rat intestinal α-glucosidase and α-amylase. This is the first report on α-glucosidase inhibitory activity of butyrolactone I. The antioxidative activity of butyrolactone I was evaluated based on scavenging effects on 1,1-diphenyl-2-picrylhydrazyl (DPPH) (IC 50 =51 μM) and hydrogen peroxide (IC 50 = 141 μM) radicals as well as a reducing power assay. The results suggest that butyrolactone I is a promising antidiabetic as well as antioxidant and should be considered for clinical trials. Keywords
Sentimental Analysis with Amazon Review Data

Analyzing and predicting consumers behavior has always been a blooming and promising area of study with great value of research. Given the existing methods in the field, sentimental analysis of texts could be feasible especially in regarding to E-commerce. By analyzing the polarity of the text, decision maker can effectively inspect the strengths and weaknesses of their products, or even anticipate the complaints and the sales amount. In this project, we used the Amazon review dataset and try to predict reviewers’ rating based on their review texts. With the help of the LSTM RNN model, we reached a final accuracy of 46.66%.