Miracle-dz/UniFAR-FTUs huggingface dataset:
Combining Motor Imagery and Action Observation with Vibratory Stimulation Increases Corticomotor Excitability in Healthy Young Adults

Vibratory stimulation but also motor imagery and action observation can induce corticomotor modulation, as a bottom-up stimulus and top-down stimuli, respectively. However, it remains unknown whether the combination of motor imagery, action observation, and vibratory stimulation can effectively increase corticomotor excitability. This study aimed to investigate the effect of motor imagery and/or action observation, in the presence or absence of vibratory stimulation, on the corticomotor excitability of healthy young adults. Vibratory stimulation was provided to the palm of the right hand. Action observation consisted in viewing a movie of someone else’s finger flexion and extension movements. The imagery condition required the participants to imagine they were moving their fingers while viewing the movie and attempting to move their fingers in accordance with the movie. Eleven right-handed healthy young adults were asked to perform six conditions randomly: 1) vibratory stimulation, imagery, and action observation, 2) vibratory stimulation and action observation, 3) vibratory stimulation and viewing of a blank screen, 4) imagery and action observation, 5) action observation, and 6) viewing of a blank screen. Single-pulse transcranial magnetic stimulation was conducted to assess corticomotor excitability and the peak-to-peak amplitude of the motor evoked potentials. The results showed that vibratory observation, and vibratory stimulation can effectively augment corticomotor excitability.
A numerical investigation of the effects of crosswinds upon the aerodynamic characteristics of a high-speed passenger train and its slipstream

The main work presented within this thesis is a numerical investigation of the effects of crosswind yaw angles upon the aerodynamic characteristics of a high-speed passenger train. The applicability of Computational Fluid Dynamic (CFD) approaches to the simulation of external flow around a passenger train were investigated. Results showed the Delayed DES (DDES) approach produced the highest correlation to experimental results. Ballast heights of 0m, 0.3m and 0.75m were simulated and compared to existing experimental results. Comparisons between cases found that a vortex from the train’s underbody follows the ballast profile. Crosswind simulations were conducted at yaw angles of 0o, 5o, 10o and 15o. The results obtained showed the formation of a large vortex upon the leeward side at yaw angles of 10o and above, this caused a region of low pressure which increased the overturning forces acting upon the train. Generally, crosswinds increased pressures upon the windward side of the train and decreased them upon the leeward side. Slipstream velocities on the windward side were seen to decrease whilst leeward side velocities increased. Results were compared to regulations currently in place for the operation and testing of trains. This enabled comments and suggestions to be made upon existing regulations.
Design and analysis of 1D photonic crystal doped with magnetized cold plasma defect for application of single/multi-channel tunable narrowband filter

The present research demonstrates the tunable filtering properties of a single/multi-channel filter based on 1D photonic crystal (PhC), which is designed with dielectric materials (A, B) and magnetized cold plasma (P). The proposed filter has a configuration of A/BMA/P/BN(A/B)M. Transmission spectra of the structure is investigated for both right-hand polarization and left-hand polarization configurations of the plasma material by employing the well-known transfer matrix method. It is found that number of periods of the plasma layer (N) decides the single-channel and multi-channel operations of the filter. It is revealed that the external magnetic field can be manipulated to tune the frequency of the filter. Also, it is found that the geometrical parameters such as thickness of the plasma layer, plasma density, and incident angle play a significant role in tuning the defect mode frequency. Moreover, the color map plot is studied to provide a clear insight of shifting nature of the defect mode frequency. Quality factor of the filter is evaluated vis-à-vis different geometrical parameters. Our considered structure can be the mainstay for filtering applications in microwave regions, and can find suitable applications in dense wavelength division multiplexing and high speed signal processing.
Older adults and family caregivers’ experience of digital health technology in frailty care: A systematic review and meta-ethnography protocol

Background: Digital health technology has been identified as a valuable tool to support older adults with frailty needs in their home setting. Despite the numerous technologies and evaluations of these innovations, a synthesis of the older person and family caregivers’ experience using technology for support self-management has not been conducted to date. Methods and analysis: A systematic review and meta-ethnography will be conducted in accordance with the PRISMA and eMERGe reporting guidelines. Four peer-reviewed empirical evidence databases will be searched (Medline (Ovid), CINAHL, EMBASE, PsycINFO) using a defined search strategy. Studies containing qualitative data on the experiences of older people or family caregivers of using digital health technology to support frailty care will be included. Covidence software will be used to screen studies and extract data. The Critical Appraisal Skills Programme (CASP) checklist for qualitative research will be used by two independent reviewers to appraise all included papers. A meta-ethnography will be undertaken in accordance with the seven-phase method described by Noblit and Hare: (1) Getting started, (2) Deciding what is relevant to the initial interest, (3) Reading the studies, (4) Determining how the studies are related, (5) Translating the studies into one another, (6) Synthesizing translations and (7) Expressing the synthesis. Discussion: To the best of our knowledge, this will be the first systematic review to integrate and synthesize the findings of qualitative studies of older citizens’ experience of digital health technology. The findings of this meta-ethnography will endeavour to inform future research, policy and clinical practice. In particular, the results will help to inform the design of future digital health technology to meet the needs of older adults. PROSPERO registration number: CRD42022314608.
Demonstration: Listen to Yourself and Others – Multiuser Mobile Biosignal Sonification Platform EMOListen

EMOListen is a multiuser mobile biosignal sonification platform. Biosignal adaptation has gained a lot of recognition in recent years both in academia and within industry. However, experimentations rarely involve multiuser systems, and they do not consider audio as the adaptation target. Biosignal sonification is a relevant domain, because audio can be used in adaptation with high temporal accuracy, can be associated to several biosignals, and can be used as a secondary stimulus, enabling long term and out-of-laboratory experimentations. Multiuser mobile sonification system can be used for creating sense of telepresence and mediated body language.
Electrospun Composite Nanofiltration Membranes for Arsenic Removal

In recent years, significant attention has been paid towards the study and application of mixed matrix nanofibrous membranes for water treatment. The focus of this study is to develop and characterize functional polysulfone (PSf)-based composite nanofiltration (NF) membranes comprising two different oxides, such as graphene oxide (GO) and zinc oxide (ZnO) for arsenic removal from water. PSf/GO- and PSf/ZnO-mixed matrix NF membranes were fabricated using the electrospinning technique, and subsequently examined for their physicochemical properties and evaluated for their performance for arsenite–As(III) and arsenate–As(V) rejection. The effect of GO and ZnO on the morphology, hierarchical structure, and hydrophilicity of fabricated membranes was studied using a scanning electron microscope (SEM), small and ultra-small angle neutron scattering (USANS and SANS), contact angle, zeta potential, and BET (Brunauer, Emmett and Teller) surface area analysis. Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) were used to study the elemental compositions and polymer-oxide interaction in the membranes. The incorporation of GO and ZnO in PSf matrix reduced the fiber diameter but increased the porosity, hydrophilicity, and surface negative charge of the membranes. Among five membrane systems, PSf with 1% ZnO has the highest water permeability of 13, 13 and 11 L h−1 m−2 bar−1 for pure water, As(III), and As(V)-contaminated water, respectively. The composite NF membranes of PSf and ZnO exhibited enhanced (more than twice) arsenite removal (at 5 bar pressure) of 71% as compared to pristine PSf membranes, at 43%, whereas both membranes showed only a 27% removal for arsenate.
Design of Rational JAK3 Inhibitors Based on the Parent Core Structure of 1,7-Dihydro-Dipyrrolo [2,3-b:3′,2′-e] Pyridine

JAK3 differs from other JAK family members in terms of tissue distribution and functional properties, making it a promising target for autoimmune disease treatment. However, due to the high homology of these family members, targeting JAK3 selectively is difficult. As a result, exploiting small changes or selectively boosting affinity within the ATP binding region to produce new tailored inhibitors of JAK3 is extremely beneficial. PubChem CID 137321159 was used as the lead inhibitor in this study to preserve the characteristic structure and to collocate it with the redesigned new parent core structure, from which a series of 1,7-dihydro-dipyrrolo [2,3-b:3′,2′-e] pyridine derivatives were obtained using the backbone growth method. From the proposed compounds, 14 inhibitors of JAK3 were found based on the docking scoring evaluation. The RMSD and MM/PBSA methods of molecular dynamics simulations were also used to confirm the stable nature of this series of complex systems, and the weak protein–ligand interactions during the dynamics were graphically evaluated and further investigated. The results demonstrated that the new parent core structure fully occupied the hydrophobic cavity, enhanced the interactions of residues LEU828, VAL836, LYS855, GLU903, LEU905 and LEU956, and maintained the structural stability. Apart from this, the results of the analysis show that the binding efficiency of the designed inhibitors of JAK3 is mainly achieved by electrostatic and VDW interactions and the order of the binding free energy with JAK3 is: 8 (−70.286 kJ/mol) > 11 (−64.523 kJ/mol) > 6 (−51.225 kJ/mol) > 17 (−42.822 kJ/mol) > 10 (−40.975 kJ/mol) > 19 (−39.754 kJ/mol). This study may provide a valuable reference for the discovery of novel JAK3 inhibitors for those patients with immune diseases.
The kids are alright: adolescents’ experiences during COVID-19 disruption

Purpose This study aimed to understand adolescents’ experiences, negative feelings and coping mechanisms associated with the major disruption caused by the COVID-19 pandemic. The purpose of this study was to develop a baseline for understanding adolescents and their environment to assist future developments of technological and other solutions to mitigate adolescents’ loneliness, improve their wellbeing and strengthen their resilience. Design/methodology/approach The data about adolescents’ experiences during the COVID-19 pandemic was collected through virtual interviews conducted via Zoom. A total of 39 adolescents (aged 12 through 18 years) primarily from the North East of the USA participated in the study. The transcripts of the interviews were analyzed using thematic analysis. Findings This study found evidence of negative disruptions to adolescents’ social, learning and emotional routines. This study also found that in dealing with the effects of COVID-19 disruption, most of the participants exhibited five key attributes of individual resilience, including social competence, problem-solving, critical consciousness, autonomy and a sense of purpose. External factors supporting resilience were also mentioned, including technology resources, family, school and broader community. Originality/value This study relied on first-hand adolescents’ reports of their experiences, feelings and coping strategies during the pandemic. This study applied a resilience framework to interpret the findings and translate them into recommendations for further development of support systems for adolescents.
Wavy Trailing Edge Feasibility for Aircraft Engine Composite Fan Blade

Attempts to add the advanced technologies to aerospace composite structures like fan blade have been on in recent times to further improve its performance. As part of these efforts, it has been proposed that the wavy trailing edge could be used in the blade to reduce the noise level. It has been also proposed that it’s structural feasibility could be studied by fabricating coupons representing blade like boundary conditions and mimicking max strain contours of wavy trailing edge of blade and testing them. Suitable size coupons (baseline flat and ones with wavy edge) were designed, and appropriate boundary condition was suggested for tests. The four-point bend tests were performed on baseline flat and wavy edge coupons and after analyzing the results it was concluded that some wavy edge configurations coupons do show some knock down in the failure load/strain but the optimized wavy edge configuration coupons show almost no knockdown (within scatter) in the failure load/strains. This leads to the conclusion that the wavy edge configuration under consideration has sufficient structural integrity as per the representative coupon test
The Oligomeric Assemblies of Cytomegalovirus Core Nuclear Egress Proteins Are Associated with Host Kinases and Show Sensitivity to Antiviral Kinase Inhibitors

The nucleo-cytoplasmic capsid egress of herpesviruses is a unique regulated process that ensures the efficiency of viral replication and release. For human cytomegalovirus (HCMV), the core of the nuclear egress complex (NEC) consists of the pUL50–pUL53 heterodimer that is able to oligomerize and thus to build hexameric lattices. These structures determine capsid binding and multicomponent protein interaction including NEC-associated host factors. The underlying characteristic of the core NEC formation is based on the N-terminal hook structure of pUL53 that binds into an alpha-helical groove of pUL50, and is thus described as a hook-into-groove interaction. This central regulatory element has recently been validated as a target of antiviral strategies, and first NEC-targeted prototypes of inhibitory small molecules were reported by our previous study. Here, we further analyzed the oligomerization properties of the viral NEC through an approach of chemical protein cross-linking. Findings were as follows: (i) a cross-link approach demonstrated the oligomeric state of the HCMV core NEC using material from HCMV-infected or plasmid-transfected cells, (ii) a Western blot-based identification of NEC-associated kinases using the cross-linked multicomponent NECs was successful, and (iii) we demonstrated the NEC-inhibitory and antiviral activity of specific inhibitors directed to these target kinases. Combined, the results strongly underline the functional importance of the oligomerization of the HCMV-specific NEC that is both phosphorylation-dependent and sensitive to antiviral kinase inhibitors.
Methodology for Switching Characterization of Power Devices and Modules

In modern power electronics systems there is a growing trend to replace discrete devices with integrated power electronic modules (IPEMs). In this way, several components can be replaced by a single component. By using prefabricated building blocks, the engineer simplifies the design process, reducing the total design cycle time and cost. By integrating only the necessary components to provide power switching, the end user has a pre-optimized building block with the flexibility to be used in a large variety of applications. Besides simplifying the design process, power modules should be designed in such a way as to improve the performance of the power converter. This begs the question as to how best to judge if one IPEM has better performance than another or better performance than its discrete counterpart. In analyzing a converter’s performance, popular criteria include efficiency, power density, device stresses, and EMI. All of these criteria are strongly linked to the switching characteristics of the IPEM’s power devices. This thesis is a comprehensive study of the requirements for obtaining and analyzing the switching characteristics of the IPEM’s power devices. It outlines the important switching characteristics and the implications of each characteristic on converter performance. It deals with the relevant measurement issues, specifically addressing the minimum requirements, which sensors are most suitable, and problems leading to inaccurate data. A parametric study is conducted to determine the effects of several circuit and operating parameters on the switching characteristics. Using the resulting data and the knowledge from the measurement study, we can decide how to design the testbed layout, what operating conditions should be chosen for testing, and what effects of the tester must be decoupled to truly see the effects of IPEM design. The thesis concludes with the design of standard test equipment and procedures.
Performance of Loop-Mediated Isothermal Amplification Technique in Milk Samples for the Diagnosis of Bovine Tuberculosis in Dairy Cattle Using a Bayesian Approach

This study aimed to estimate the sensitivity (Se) and specificity (Sp) of loop-mediated isothermal amplification (LAMP) and single intradermal tuberculin (SIT) tests for the diagnosis of bovine tuberculosis (bTB) in dairy cattle in Thailand using a Bayesian approach. The SIT test was performed in 203 lactating dairy cattle from nine dairy farms located in Chiang Mai province, Thailand. Milk samples were collected for the LAMP test. Kappa analysis was performed to determine the agreement between the two tests. A one-population conditional independence Bayesian model was applied to estimate the Se and Sp of the two tests. Of 203 dairy cattle, 2 were positive for the SIT test using standard interpretation, whereas 38 were positive for the LAMP test. A poor agreement (kappa = 0) was observed between the two tests. The median Se and Sp of the SIT test using standard interpretation were 63.5% and 99.1%, respectively. The median Se and Sp of the LAMP test were 67.2% and 82.0%, respectively. The estimated true prevalence of bTB was 3.7%. The LAMP test with milk samples can potentially be used as a non-invasive screening test for the diagnosis of bTB in dairy cattle.
Bipartite Graphs and Recommendation Systems

—Bipartite graphs are used to model many real-world relationships with applications in several domains, such as: medicine, social networks and marketing. Examples of such relationships include drugs-adverse reactions associations, links between genes and various pathologies, actors and the movies they play in, researchers and the papers they author. We explore several properties of bipartite graphs and propose several notions including the measure of biclique similarity of a set of vertices, the measure of biclique connectivity of a set of vertices, and the notion of chains in bipartite graphs. We introduce the Biclique Similarity Ordering Recommendation (BISOR) algorithm, an application of maximal bicliques of bipartite graphs to recommendation systems that makes use of the notion of biclique similarity of a set of vertices in order to recommend items to users in a certain order of preference. We justify our approach by presenting experimental results that use real-world datasets: Sushi, MovieLens 100k and MovieLens
Vehicle target detection algorithm based on improved YOLOv3

The detection of road vehicle targets is an important research direction in the field of target detection. As there is some problem in vehicle target detection while using YOLOv3, such as high miss rate and low detection accuracy, an improved multi-scale feature fusion target detection algorithm IFFC-YOLOv3 is proposed. Firstly, optimizing the multi-scale feature fusion based on the YOLOv3 algorithm to improve the detection of small targets while ensuring the detection capability of the network for medium and large targets. Secondly, using K-Means++ target frame clustering on road target detection turns out to obtain new candidate frames to improve its accuracy. Finally, the CIoU optimized loss function is introduced to further improve the accuracy of vehicle target detection. In this paper, the effect of the improved IFFC-YOLOv3 algorithm is verified by means of a personal datasets. The experimental results show that the IFFC-YOLOv3 algorithm achieves good detection results in terms of reducing the rate of missed detection and improving the detection accuracy.
Traffic engineering software

U posljednje vrijeme pojedini su racunarski modeli razvijeni za podrsku prometnim inženjerima u rjesavanju problema u prometu. Iako prometno inženjerstvo ima kontinuitet u izucavanju tzv. "rucnih" metoda, racunarski pristup sve se vise primjenjuje u prometnim analizama, te oblikovanju prometnih rjesenja. Mnogi autori pisali su najvecim djelom o racunarskim programima optimizacije signalnih vremena, te o simulacijama prometa.
Design a Nonlinear MPC Controller for Autonomous Mobile Robot Navigation System Based on ROS

—Navigation is an essential problem for self-propelled robots, in which the orbital control system plays a decisive role in the robot's behavior and navigating the robot to move in space. This paper presents the tutorial approach for the design and construction of the Nonlinear Model Predictive Control controller for the four-wheeled Omni robot in the orbital tracking problem. The designed controller is implemented in the navigation stack system for the robot to follow the specified trajectory smoothly and avoid collision with surrounding obstacles simultaneously. The results are presented in both theory and simulation cases owing to the ROS platform to illustrate the validity and effectiveness of the method for the trajectory tracking problem combined with the navigation stack system. Besides the advantage of the designed navigation stack is also demonstrated through comparison with the TEB planner.