Miracle-dz/UniFAR-FTUs huggingface dataset:
The U.S. Wide-Area Augmentation System (WAAS)

GPS as provided by DOD will give civil aviation users around the world an accurate navigation system that can be used for all phases of flight except precision approach. For densely traveled airspace such as the National Airspace System (NAS) in the United States, GPS by itself does not provide the required availability to serve as the primary-means navigation system. Therefore, the FAA has designed, developed, and tested a concept called the Wide-Area Augmentation System (WAAS). GPS augmented by WAAS can provide the integrity, accuracy, and availability required for a primary-means navigation system for all phases of flight up to Category (CAT) I precision approach in the NAS. This paper provides a summary of the FAA's satellite navigation program, and the strategy and plans for implementing a new satellite navigation system completely different from today's ground-based systems. It addresses both the operational and technical considerations and requirements involved in implementing WAAS, including the cross-country flight tests that provided the needed verification to justify a contract award to build and implement an initial WAAS in 1998. The paper also addresses the worldwide expansion of WAAS so that any nation can contribute as little or as much as it wants to a worldwide seamless WAAS.
Characterization of root-associated bacterial species of Leklek variety of common bean (Phaseolus sp.)

The common bean is a valuable food source in the human diet. Leklek is a local variety of common bean (Phaseolus sp.) widely grown in Mersin's Gülnar district, but little is known about this variety. In the present study, bacterial species from root nodules of this common bean variety were identified by PCR-amplified 16S ribosomal RNA (rRNA) gene and 16S-23S ribosomal RNA (rRNA) Internal Transcribed Spacer (ITS) region and sequencing. The partial 16S rRNA gene and 16S-23S rRNA ITS region sequences were submitted to the NCBI database (accession numbers MT967369, MT968518, respectively). Amplified sequences were used to construct a phylogenetic tree. Phylogenetic analysis based on the identified sequences showed that the isolate belonged to the genus Microbacterium and was closely related to Microbacterium paraoxydans. The findings presented here will provide a clue for understanding this bacterium's role in nodule formation in Phaseolus sp. (variety Leklek).
An extended approach to calculate the ozone relative response factors used in the attainment demonstration for the National Ambient Air Quality Standards

With the promulgation of the National Ambient Air Quality Standards (NAAQS or standard) for 8-hr ozone (O3), the U.S. Environmental Protection Agency (EPA) issued modeling guidance that advocated the use of results from photochemical air quality models in a relative sense. In doing so, the EPA provided guidance on how to calculate relative response factors (RRFs) that can project current design value (DV) mixing ratios into the future for the purpose of determining the attainment status with respect to the O3 standard. The RRFs recommended by the EPA represent the average response of the photochemical model over a broad range of O3 mixing ratios above a specified cutoff threshold. However, it is known that O3 response to emission reductions of limiting precursors (i.e., NOx and/or VOC) is greater on days with higher O3 mixing ratios compared to days with lower mixing ratios. In this study, we present a segmented RRF concept termed band-RRF, which takes into account the different model responses at different O3 mixing ratios. The new band-RRF concept is demonstrated in the San Joaquin Valley (SJV) region of California for the 1-hr and 8-hr O3 standards. The 1-hr O3 analysis is relevant to work done in support of the SJV O3 State Implementation Plan (SIP) submitted to the EPA in 2013. The 8-hr example for the future year of 2019 is presented for illustrative purposes only. Further work will be conducted with attainment deadline of 2032 as part of upcoming SIPs for the 0.075 parts per million (ppm) 8-hr O3 standard. The applicability of the band-RRF concept to the particulate matter (PM2.5) standards is also discussed. Implications: Results of photochemical models are used in regulatory applications in a relative sense using relative response factors (RRFs), which represent the impacts of emissions reductions over a wide range of ozone (O3) values. It is possible to extend the concept of RRFs to account for the fact that higher O3 mixing ratios (both 1-hr and 8-hr) respond more to emissions controls of limiting precursors than do lower O3 mixing ratios. We demonstrate this extended concept, termed band-RRF, for the 1-hr and 8-hr O3 National Ambient Air Quality Standard (NAAQS or standard) in the San Joaquin Valley of California. This extension can also be made applicable to the 24-hr PM2.5 and annual PM2.5 standards.
CYCLON and NPM1 Cooperate within an Oncogenic Network Predictive of R-CHOP Response in DLBCL

Simple Summary CYCLON is a nuclear protein, which has been associated with disease progression and treatment resistance in DLBCL, the most common form of aggressive B-cell lymphoma, but also represents a predictive factor of refractory disease and relapse for immuno-chemotherapy-treated DLBCL patients. The molecular mechanisms related to this unstructured protein remain largely uncharacterized. Here, we performed a mass-spectrometry-based identification of the CYCLON protein interactome that suggested it could exert nucleolar functions related to cell proliferation. Among the CYCLON oncogenic network, we performed an immunohistochemical evaluation of the multi-functional nucleolar protein NPM1 in a DLBCL cohort and showed that CYCLON/NPM1 concomitant expression delineates a poor prognosis subgroup of patients. Multivariate survival analyses demonstrated that specific sub-cellular localizations of CYCLON and NPM1 represent independent novel predictors specifically associated with refractory DLBCL. Abstract R-CHOP immuno-chemotherapy significantly improved clinical management of diffuse large B-cell lymphoma (DLBCL). However, 30–40% of DLBCL patients still present a refractory disease or relapse. Most of the prognostic markers identified to date fail to accurately stratify high-risk DLBCL patients. We have previously shown that the nuclear protein CYCLON is associated with DLBCL disease progression and resistance to anti-CD20 immunotherapy in preclinical models. We also recently reported that it also represents a potent predictor of refractory disease and relapse in a retrospective DLBCL cohort. However, only sparse data are available to predict the potential biological role of CYCLON and how it might exert its adverse effects on lymphoma cells. Here, we characterized the protein interaction network of CYCLON, connecting this protein to the nucleolus, RNA processing, MYC signaling and cell cycle progression. Among this network, NPM1, a nucleolar multi-functional protein frequently deregulated in cancer, emerged as another potential target related to treatment resistance in DLBCL. Immunohistochemistry evaluation of CYCLON and NPM1 revealed that their co-expression is strongly related to inferior prognosis in DLBCL. More specifically, alternative sub-cellular localizations of the proteins (extra-nucleolar CYCLON and pan-cellular NPM1) represent independent predictive factors specifically associated to R-CHOP refractory DLBCL patients, which could allow them to be orientated towards risk-adapted or novel targeted therapies.
Phases of Magmatic Activities in South Wadi Hodein-Shalatein, Egypt: Resolving controversy about their age using Paleomagnetism and AMS

ABSTRACT Several exposures of basaltic intrusions are distributed near Red Sea coast at Wadi Hodein Southern Egypt. There is some disagreement about the palaeomagnetic pole results of these basalts; some claim it is Tertiary in age, while others claim it is of Cretaceous age. To our knowledge, no Anisotropy of Magnetic Susceptibility (AMS) results have ever been published from these rocks. Therefore, palaeomagnetic and AMS studies were performed on these basalts in order to identify phases of magmatism, paleomagnetic pole position and types of magmatic intrusions. In the present study, eight sites (219 oriented core specimens) were sampled from eight location. Rock magnetic studies reflect the presence of magnetite as the chief mineral in these rocks. Alternating field technique in association with Thermal Demagnetisation process revealed presence of one magmatic phase took place in Cretaceous age with VGP (65°N, 250°E; A 95 = 5.3). AMS results showed that the basaltic intrusions in the study area are still holding their primary fabrics.
Robust Unit Root Tests for a Panel TAR Model

Robust unit root tests are developed for dynamic panels consisting of TAR processes. The test statistics are all based on diverse combinations of individual t-type tests for significance of TAR coefficients. Limiting null distributions are established. A Monte-Carlo experiment compares the proposed tests. The tests are applied to a panel data set of Canadian unemployment rates which show asymmetric features as well as having outliers.
The Spillover Effect of Labor Agglomeration on Regional Economic Growth

Under the background that China's labor force is decreasing and they can move freely, this paper selects the Spatial Doberman model with time-individual fixed effects to analyze and study the spatial spillover effect and its impact mechanism of the labor agglomeration of 31 provinces in mainland China from 2003 to 2018 on regional economic growth. It was found that in China, the increase in the concentration of labor in a region and surrounding areas can promote economic growth in the region through the increase in marketization and the decline in the dependency ratio. However, the current regional economic growth in China is manifested by the promotion of labor agglomeration in the region and the suppression of labor agglomeration in the surrounding areas.
Quantitative imaging of transient acoustic fields by optical heterodyne interferometry

We have built an optical imaging system of acoustic fields transmitted in water by piezoelectric transducers. This system includes a thin reflective membrane immersed in front of the transducer and a broadband compact heterodyne interferometer. The motion of the membrane, induced by the acoustic pressure, modulates the phase of a reflected optical wave. A coherent demodulation provides the absolute mechanical displacement. To record the acoustic field, the transducer is moved parallel to the membrane. Experiments carried out with focused or planar transducers show the capability of this system to map acoustic field displacements as low as 1 Å, with a high resolution both in time (10 ns) and spatial (20 μm) domains. As an example of applications, the acoustic field was plotted in the focal plane of a 25-MHz focused transducer having a beam waist of 0.25 mm. In the case of planar transducers, B-scans of the transmitted acoustic field, clearly show the occurrence of plane waves and edge waves. Surface motions of piezocomposite transducers have also been investigated
Coinfection of Bartonella spp. and Borrelia Burgdorferi in Ixodes Scapularis Using PCR Assay, a Case Study in Nova Scotia

Coinfection of vector species can provide more insight into the complex relationship between zoonotic pathogens and its host. Ixodes scapularis (Say) or the deer-tick in particular is an important species in North America because of its exceptional ability as a vector that can transmit zoonotic diseases such as Lyme and Cat Scratch Disease (CSD). In recent years, many studies have suggested a possible link between the coinfection of Borrelia burgdorferi, the causative agent of Lyme, with other tick-borne bacteria such as Bartonella spp. , the causative agent of CSD, as partly responsible for the symptoms associated with Chronic Lyme Disease or Post-Treatment Lyme Disease Syndrome. This study investigates the prevalence of Bartonella spp. and Borrelia burgdorferi in Ixodes scapularis using Polymerase Chain Reaction (PCR) assay to potentially find a link between the two of the most common tick-borne pathogens found in Nova Scotia. Standard PCR using primers targeted at the two bacterial species were conducted on 157 I. scapularis ticks collected in Nova Scotia. Overall, we found high prevalence for both bacteria at 75.16% for Bartonella spp. and 47.13% for B. burgdorferi with no significant differences between the sex of the ticks. Interestingly, all the ticks positive for B. burgdorferi were also positive for Bartonella spp. which implies that the coinfection rate between B. burgdorferi and Bartonella spp. is 47.13%. We report one of the highest coinfection rates for B. burgdorferi and Bartonella spp. in I. scapularis, consistent with the current trends of increasing tick presence in North America.
Quality assurance and effectiveness of audit systems

Quality audits are prominent and proven management tools for assessing compliance and effectiveness of quality systems. They are commonly used in the effort to improve overall business performance. However, similarly to any other physical or conceptual system, they may fail to achieve objectives set forth, raising concerns among auditees and clients alike. Argues for the provision of adequate confidence to various interested parties in the quality of auditing services. A quality audit is conceptualized using the systems approach. Subsequently, a quality assurance framework based on the application of the 1994 and 2000 versions of the ISO 9001 standard in auditing is presented. Audit system effectiveness is modeled using the concepts of audit reliability, availability and suitability. Audit failures, risks and maintainability are addressed in detail. It is concluded that audit managers must ensure appropriate levels of quality and effectiveness of quality audit systems.
A Cardioplegic Solution with an Understanding of a Cardiochannelopathy

Cardiac surgeries have been improved by accompanying developing cardioplegia solutions. However, the cardioplegia application presents an ongoing challenge with a view of a sufficiently restored cardiac function. In this review, we focus on the cardioplegia-induced mechanism and summarize the findings of studies undertaken to improve cardioprotective strategies. Currently, and somewhat surprisingly, relatively little is known about cardiac electrolyte regulation through channel physiology. We hope that an improved understanding of the electrolyte transport through ion channels/transporters and modulations of water channel aquaporins will provide an insight into cardiac channel physiology and a channel-based cardiac pathology of a cardiochannelopathy.
Multi-period automatic fitting of pulse duration improves NMRG longitudinal relaxation time measurement accuracy

Nuclear magnetic resonance gyroscopes(NMRG) have received widespread attention to the fields of national defense and civil applications due to their potential for miniaturization and low cost. The relaxation time is an important parameter to measure the performance of the alkali vapor cell of the NMR gyroscope, the most commonly used industry standard measurement method of longitudinal relaxation time(T1) is the measurement method using π pulse plus 1/2π pulse, so the measurement accuracy of the T1 is affected by the accuracy of the pulse duration. Usually the maximum value of the signal amplitude correspond to the time of 1 /2πpulse duration, but it cannot eliminate the influence of the random error of the system, the use of multiple cycles to automatically fit the pulse duration improves the accuracy of the pulse duration, saves a lot of measurement time, eliminates human error, and ultimately improves the T1 measurement accuracy.
Real-time removal of stimulation artifacts in closed-loop deep brain stimulation

Objective. Closed-loop deep brain stimulation (DBS) with neural feedback has shown great potential in improving the therapeutic effect and reducing side effects. However, the amplitude of stimulation artifacts is much larger than the local field potentials, which remains a bottleneck in developing a closed-loop stimulation strategy with varied parameters. Approach. We proposed an irregular sampling method for the real-time removal of stimulation artifacts. The artifact peaks were detected by applying a threshold to the raw recordings, and the samples within the contaminated period of the stimulation pulses were excluded and replaced with the interpolation of the samples prior to and after the stimulation artifact duration. This method was evaluated with both simulation signals and in vivo closed-loop DBS applications in Parkinsonian animal models. Main results. The irregular sampling method was able to remove the stimulation artifacts effectively with the simulation signals. The relative errors between the power spectral density of the recovered and true signals within a wide frequency band (2–150 Hz) were 2.14%, 3.93%, 7.22%, 7.97% and 6.25% for stimulation at 20 Hz, 60 Hz, 130 Hz, 180 Hz, and stimulation with variable low and high frequencies, respectively. This stimulation artifact removal method was verified in real-time closed-loop DBS applications in vivo, and the artifacts were effectively removed during stimulation with frequency continuously changing from 130 Hz to 1 Hz and stimulation adaptive to beta oscillations. Significance. The proposed method provides an approach for real-time removal in closed-loop DBS applications, which is effective in stimulation with low frequency, high frequency, and variable frequency. This method can facilitate the development of more advanced closed-loop DBS strategies.
On the Design of Magnetic Resonant Coupling for Wireless Power Transfer in Multicoil Networks

Wireless power transfer (WPT) is a promising technology for powering up distributed devices in machine type networks. Over the last decade magnetic resonant coupling (MRC) received significant interest from the research community, since it is suitable for realizing mid-range WPT. In this letter, we investigate the performance of a single cell MRC-WPT network with multiple receivers, each equipped with an electromagnetic coil and a load. We first consider pre-adjusted loads for the receivers and by taking into account spatial randomness, we derive the harvesting outage probability of a receiver; for both the strong and loosely coupling regions. Then, we develop a non-cooperative game for a fixed receiver topology, in order to acquire the optimal load which maximizes each receiver’s harvested power. Throughout our work, we obtain insights for key design parameters and present numerical results which validate our analysis.
MmpA, a Conserved Membrane Protein Required for Efficient Surface Transport of Trehalose Lipids in Corynebacterineae

Cell walls of bacteria of the genera Mycobacterium and Corynebacterium contain high levels of (coryno)mycolic acids. These very long chain fatty acids are synthesized on the cytoplasmic leaflet of the inner membrane (IM) prior to conjugation to the disaccharide, trehalose, and transport to the periplasm. Recent studies on Corynebacterium glutamicum have shown that acetylation of trehalose monohydroxycorynomycolate (hTMCM) promotes its transport across the inner membrane. Acetylation is mediated by the membrane acetyltransferase, TmaT, and is dependent on the presence of a putative methyltransferase, MtrP. Here, we identify a third protein that is required for the acetylation and membrane transport of hTMCM. Deletion of the C. glutamicum gene NCgl2761 (Rv0226c in Mycobacterium tuberculosis) abolished synthesis of acetylated hTMCM (AcTMCM), resulting in an accumulation of hTMCM in the inner membrane and reduced synthesis of trehalose dihydroxycorynomycolate (h2TDCM), a major outer membrane glycolipid. Complementation with the NCgl2761 gene, designated here as mmpA, restored the hTMCM:h2TDCM ratio. Comprehensive lipidomic analysis of the ΔtmaT, ΔmtrP and ΔmmpA mutants revealed strikingly similar global changes in overall membrane lipid composition. Our findings suggest that the acetylation and membrane transport of hTMCM is regulated by multiple proteins: MmpA, MtrP and TmaT, and that defects in this process lead to global, potentially compensatory changes in the composition of inner and outer membranes.
Development of a calibrator based on Fabry-Pérot etalon for high resolution spectrograph

The ﬁber-fed High Resolution Spectrograph of the Chinese Xinglong 2.16-m Telescope is the main instrument for high precision spectral detection in China. In order to improve the observation performance, a wavelength calibrator based on Fabry-P´erot etalon (FPE) is developed. Here, we report on the design, transmission charac-teristics and vacuum-thermostatic performance of the system. To meet the requirements of the calibration, the calibrator is custom-designed with the FPE gap of 5 mm, ﬁneness value of 40, and illuminating ﬁber of 100 μm in diameter, which could generate calibration lines with 30 GHz in lines space and covering 500 – 700 nm.
Air Gap Control Simulation of Maglev Vehicles with Feedback Control System

The purpose of this paper is to more realistically predict the air gaps of the maglev vehicles under consideration. For doing so, the much more detailed dynamic modeling techniques, considering all the components are presented. In EMS-type maglev, air gap which is clearance between guideway surface and supporting magnet should be maintained within a limited value for preventing physical contact. The levitation control unit consists of electromagnets, gap sensors, choppers, and a controller. Thus, it would be desirable to include all the mechanical and electrical parts in the air gap simulation model. With the proposed model, air gaps are simulated to evaluate whether the mechanical contact would be occurred at maximum design speed.
A sensorless initial rotor position estimation scheme for a direct torque controlled interior permanent magnet synchronous motor drive

This paper presents a method of determining the initial rotor position of an interior permanent magnet synchronous motor (IPMSM) which is required for direct torque controlled (DTC) IPMSM drives. The method consists of injecting a high frequency voltage to the windings and examining the effects of the saliency on the amplitude of the corresponding stator current components. This method does not depend on the level of static load and on any motor parameters. Also the magnetic pole is identified utilizing the effect of magnetic saliency.
Work Engagement as a Consequence of Work Overload and Intimidation: The Moderating role of Spiritual Leadership and Organizational Climate

Purpose The purpose of the study seeks to proposed and test a research model that investigates impact of work-overload on employee engagement and employee psychological wellbeing via mediating role of intimidation and moderating role of spiritual leadership and organizational climate by employing moderation-mediation- moderation model Design/Methodology/Approach: The data was collected from 351 pharmaceutical employees working as sales force. The study issuing convenient sampling technique. Smart PLS-SEM was used for data analysis. Findings: The result of SEM findings revealed that spiritual leadership fails to moderate the relationship in the perspective of existing framework whereas organization climate moderates the relationship between intimidation and employee engagement, which indicates that even the intimidated employees got engaged in their work in the presence of supportive organization climate. Implications/Originality/Value: The study framework and methodology contribute in the existing literature and creates future horizons for the scholars. Longitudinal data might be valuable in future studies for establishing causal extrapolations between study variables. Future studies could benefit from incorporating cross-cultural study. Our insights can even be extended to employees in plenty of other workplaces wherein everyday organizational interactions are necessary