Miracle-dz/UniFAR-FTUs huggingface dataset:
Predicting Drug-Drug Interactions from Text using NLP and Privileged Information

Objective: The medication prescribed to help treat a condition can also be detrimental to a person’s health: drug-drug interactions or adverse drug events (ADEs) can be deadly, and after four concurrent medications the chance of encountering one increases exponentially. As further motivation, it is nearly impossible for every drug-drug combination to be represented during clinical trials, nor is it possible to encapsulate the breadth of genetic diversity between people that will inevitibably use these drugs. Among the possible solutions to this problem, we applied machine learning and natural language processing (NLP) to data from drug labels and scientific studies. Furthermore, we show that privileged information from medical blogs can be incorporated to improve our model. Using this method, we can accurately predict drugs and their events, and if used effectively, this can improve safety and allow patients to make informed health decisions. Methods: We mined data from three sources: the openFDA drug label database, PubMed, and a variety of medical blogs (Dailystrength, et al.). After building our dataset, we labeled for keywords that could be processed with Stanford NLP (”interacts with”, ”inhibits cytochrome p450 production”), then applied a Recurrent Neural Network (RNN) to model the ADEs. Results: We got results and they were pretty cool. Conclusions: We drew a conclusion from our pretty cool results.
The ATLAS Forward Calorimeter

Forward calorimeters, located near the incident beams, complete the nearly 4π coverage for high pT particles resulting from proton-proton collisions in the ATLAS detector at the Large Hadron Collider at CERN. Both the technology and the deployment of the forward calorimeters in ATLAS are novel. The liquid argon rod/tube electrode structure for the forward calorimeters was invented specifically for applications in high rate environments. The placement of the forward calorimeters adjacent to the other calorimeters relatively close to the interaction point provides several advantages including nearly seamless calorimetry and natural shielding for the muon system. The forward calorimeter performance requirements are driven by events with missing ET and tagging jets.
QUARQ: A Novel General Purpose Multicore Architecture for Cognitive Computing

—The recent success of deep neural networks on challenging problems have provoked both academia and industry to design efﬁcient specialized hardware to improve the performance and energy requirements for training and evaluating state-of-the-art neural networks. In this context, many specialized accelerator designs have been proposed. For this work, instead of designing a specialized piece of hardware, we propose a general purpose multi-core architecture called QUARQ that provides state-of-the-art performance for neural network workloads. QUARQ is a tiled multi-core architecture which contains both shared memory and explicit messaging capabilities for inter-core communication. QUARQ enables scalable computation, memory and communication for neural networks. For computation, QUARQ enables a short-SIMD (64-bit) pipeline per core. Each short-SIMD can perform four 16-bit precision MAC operations. QUARQ enables an intelligent 2-level cache hierarchy that exploits data reuse at the L1 levels, and caches per-frame dataset on-chip in the L2 cache, avoiding expensive off-chip memory accesses leading to near optimal memory bandwidth usage. QUARQ enables extremely scalable communication by combining the hardware based cache coherence protocol with in-hardware explicit messaging. This allows ﬁne-grain concurrency to be exploited within a single neuron since communication overheads are much smaller than the beneﬁts achieved from data reuse enabled by ﬁne-grain concurrency. The simulation based evaluations results show that 512 cores with a short-SIMD pipeline per core provides 165 frames per second performance for ALEXNET, which is a classical neural network workload.
Modeling the Galactic center emission from GeV to PeV

The H.E. S.S. collaboration recently reported a new analysis of the gamma-ray diffuse emission from a “semi-annulus” region of 1.4 × 10−4 steradiants around Sagittarius A*. The gamma-ray spectral energy distribution measured from this region suggests the presence of interacting cosmic rays at PeV energies. This analysis adds a important piece to the previous measurements obtained with Fermi-LAT, H.E. S.S. and VERITAS telescopes in this particular region of the Central Molecular Zone. Here we describe this diffuse gamma-ray emission observed around the galactic center within a comprensive model implying a cosmic-ray population with a harder spectrum in the central part of the galaxy respect to the standard scenarios. With this phenomenological model we obtain the expected diffuse gamma-ray and neutrino components for this target rich region considering the energy range from GeV to PeV. While for the gamma-ray expectations we compare the results with the data of the mentioned experiments, for the expected neutrino spectra we consider the possibility to observe the signal with Cherenkov telescopes.
Health Care Experiences of Transgender Binary and Nonbinary University Students

An increasing number of young adults identify with nonbinary gender identities. Yet health providers and therapists often lack understanding of such identities. In this mixed-methods study of 506 transgender undergraduate and graduate students, most of whom (75%) had nonbinary gender identities, we aimed to understand participants’ mental health and health care experiences, and factors related to misgendering and less affirming treatment by providers. Eighty-five percent of participants reported mental health challenges, and named fear of violence and nonsupport as distal stressors. Experiences with therapists and health providers were mixed. Salient features of negative interactions were invalidation, avoidance, or overemphasis in regard to participants’ nonbinary identities. Participants viewed counseling services as more affirming than health services. Nonbinary students reported more misgendering by therapists and health providers, and less trans-affirming care by health service providers, compared to binary students. Undergraduate students reported more misgendering by therapists and health providers than graduate students.
Boets, E. et al. (2017) Systemic availability and metabolism of colonic- derived short-chain fatty acids in healthy subjects: a stable isotope

The short-chain fatty acids (SCFAs), acetate, propionate and butyrate are bacterial metabolites that mediate the interaction between diet, the microbiota and the host. In this study, the systemic availability of SCFAs and their incorporation into biologically relevant molecules was quantified. Known amounts of 13 C-labelled acetate, propionate and butyrate were introduced in the colon of 12 healthy subjects using colon delivery capsules and plasma levels of 13 C-SCFAs and of 13 C-glucose, 13 C-cholesterol and 13 C-fatty acids were measured. The butyrate producing capacity of the intestinal microbiota was quantified as well. Systemic availability of colonic-administered acetate, propionate and butyrate was 36%, 9% and 2%, respectively. Conversion of acetate into butyrate (24%) was the most prevalent interconversion by the colonic microbiota and was not related to the butyrate-producing capacity in the faecal samples. Less than 1% of administered acetate was incorporated into cholesterol and <15% in fatty acids. On average, 6% of colonic propionate was incorporated into glucose. The SCFAs were mainly excreted via the lungs after oxidation to 13 CO2 whereas less than 0.05% of the SCFAs were excreted into urine. These results will allow future evaluation and quantification of SCFAs production from 13 C-labelled fibres in the human colon by measuring 13 C-labelled SCFA concentrations in blood.
Carbamazepine can induce kidney water absorption by increasing aquaporin 2 expression

Background. Carbamazepine (Carba) is an anticonvulsant and psychotropic drug used widely for the treatment of intellectual disability and severe pains, but the incidence of hyponatremia is a common related occurrence. This hyponatremia is frequently attributed to a SIADH induced by this drug. It is also known that Carba is used to decrease the urinary volume in Diabetes Insipidus (DI) because it has an antidiuretic effect. Lithium (Li) is one of the most important drugs used to treat bipolar mood disorders. However Li has the undesirable capacity to induce DI. Nowadays, the association of these drugs is used in the treatment of patients with psychiatric and neurological problems. Methods. In vivo and in vitro (microperfusion) experiments were developed to investigate the effect of Carba in the rat Inner Medullary Collecting Duct (IMCD). Results. The results revealed that Carbawas able to stimulate the V2 vasopressin receptor-Protein G complex increasing the water permeability (Pf) and water absorption. In vivo studies showed that in rats with lithium-induced DI, Carba decreased the urinary volume and increased the urinary osmolality. AQP2 expression was increased both in normal IMCD incubated with Carba and in IMCD from lithiuminduced DI after Carba addition to the diet, when compared with the control. Conclusion. These results showed that the hyponatremia observed in patients using this anticonvulsant drug, at least in part, is due to the Carba capacity to increase IMCD’s Pf and that the Lithium-Carbamazepine association is beneficial to the patient.
Modeling Observed Heterogeneity LEARNING OUTCOMES 1

Relationships in PLS path models imply that exogenous latent variables explain endogenous latent variables without any systematic influences of other variables. In many instances, however, this assumption does not hold. For example, respondents are likely to be heterogeneous in their perceptions and evaluations of latent variables, yielding significant differences in, for example, path coefficients across two or more groups of respondents (e.g., females vs. males). Recognizing that heterogeneous data structures are often present, researchers are increasingly interested in identifying and understanding such differences. In fact, failure to consider heterogeneity can be a threat to the validity of partial least squares structural equation modelling (PLS-SEM) results (Becker, Rai, Ringle, & Völckner, 2013; Hair, Sarstedt, Ringle, & Mena, 2012).
A global comparison of beetle community composition on green roofs and the potential for homogenization

Globalization may confer a competitive advantage to species that are urban exploiters and result in homogenization of communities in cities. We tested the application of this hypothesis to green roofs. Using body size as a proxy for life-history strategy, we compared small-bodied and large-bodied subsets of beetle communities from 5 cities in Europe and North America. We found that city was an important organizer of both subsets, though more so for the large-bodied one. This result suggests either resilience against homogenization or simply that not enough time has occurred for it to develop. A majority of the 10 most-abundant species found in the North American cities were non-native, in contrast to those found in European cities, a majority of which were native. These findings signal that more research is needed to track drivers of homogenization, such as functional composition, on rooftops as well as in other urban green spaces.
DNA typing from steel cable

The aim of this study is to analyze the possibility of DNA typing, on the specimen recovered at the crime scene. The optimization of extraction was carried out via an experimental system to reproduce the contact with the victim. The results obtained will be described in detail. D 2003 Elsevier B.V. All rights reserved.
The implications of the liberalization in telecommunication markets for market structure and price policy: evidence from a small open economy

This study analyses the impact of liberalization on market structure and pricing in the Greek telecommunication market from 1992 to 2005. The data refers to 44 of the most prominent companies of fixed telephony, mobile telephony and internet services and was compiled by means of interviews with the help of a questionnaire. Our descriptive analysis concluded that liberalization of the telecommunication market reduced its concentration degree, increased competition and induced price cuts. This conclusion is supported by other research studies concerning other countries of the EU, since Greece as an EU member country has also implemented the respective European policy in the specific industry. As far as the econometric level is concerned, we used panel Feasible Generalized Least Squares (FGLS). FGLS is an appropriate tool for samples such as our own, composed by intersectoral data that extend to more than one time periods, and without correlation between the unobserved effects and the interpretative variables. Our econometric research showed that both private ownership and specialized personnel in the commercial and technical sector seem to positively influence the companies' market share. In turn, a large market share offers companies more freedom to cut down prices in their services. However, there is still considerable need for econometric research in this field.
Performance and Intramuscular Fatty Acid Composition of Holstein Male Calves Fed Canola Oil Containing Diets

Twenty-four Holstein male calves (BW=217±57 kg, age ~8 months) were used to study the effects of canola oil supplementation on growth, total-tract digestibility, carcass and meat chemical composition and fatty acid profile of longissimus muscle in a completely randomized design. The calves were divided into three groups and allocated to three diets: a control corn/barley-based diet (C); a diet containing 2% (DM basis) canola oil (+Oil2%); and a diet containing 4% (DM basis) canola oil (+Oil4%). Amount of feed offered was recorded daily and the calves were weighed in the start and before slaughter after 4 months of trial. The results indicated that dry matter intake was greater for calves fed C diet than +Oil2% and +OIL4% (P<0.05), but feed efficiency was lower for calves fed C diet than +Oil2% and +OIL4% (P<0.05). There were no differences in average daily gain (ADG), hot carcass weight, longissimus muscle area (P>0.05). No differences were detected (P>0.05) in carcass measurements except for back fat, in which calves fed the +OIL4% diet had more back fat compare to those fed the C diet (P<0.05). Digestibility of dry matter (DM), organic matter (OM), neutral detergent fibre (NDF), nitrogen-free extract (NFC) and crude protein (CP) did not differ among treatments (P>0.05). Digestibility of ether extract (EE) was greater for the +Oil2% and +OIL4% diets compare to C diet (P<0.05). Feeding +Oil2% and +OIL4% diets increased the percentage of C18:0 and C18:1 and decreased the percentage of C16:0 and C16:1in longissimus muscle (P<0.05). There were no differences in the percentage of C14:0, C17:0, C17:1, C18:2 and C18:3 among treatments (P>0.05). The addition of canola oil in the diet of calves improved animal performance and muscle chemical composition and had minimal effects on carcass characteristics and diet digestibility.
Early pregnancy Functional regulation of thymic stromal lymphopoietin on proliferation and invasion of trophoblasts in human first-trimester pregnancy

background: Thymic stromal lymphopoietin (TSLP) is a novel cytokine that triggers the dendritic cell-mediated TH2 response and regulatory T cell expansion. The aim of this study is to evaluate whether TSLP and TSLP receptor (TSLPR) are expressed in primary human extravillous trophoblast (EVT), how proimflammatory cytokines (tumor necrosis factor (TNF)-a, IL-1b), TH2 and TH3 cytokines (IL-4, TGF-b) and pregnancy-associated hormones regulate TSLP production by EVT and whether the SLP–TSLPR interaction affects the biological behavior of trophoblsts. methods: We assessed TSLP mRNA and protein expression by real-time RT–PCR, ELISA and immunochemistry, respectively. We further investigated effects of TSLP on the proliferation and invasion of trophoblast cells in vitro. results: The primary EVTs constitutively expressed TSLP and TSLPR. IL-4 and TNF-a or pregnancy-associated hormones result in a significant increase in TSLP mRNA expression and protein release from EVT, and TSLP promotes primary EVT proliferation and invasion in vitro. conclusions: This study has demonstrated that the first-trimester human trophoblast cells express TSLP and TSLPR, that cytokine milieu which mimics the maternal– fetal interface modulates expression of TSLP in trophoblast and that TSLP stimulates trophoblast proliferation and invasion. This suggests that TSLP plays an important role in human EVT invasion and placentation in human early pregnancy.
Quarterly arly childhood educators ’ knowledge , beliefs , education , xperiences , and children ’ s language-and literacy-learning pportunities : What is the connection ?

In this study, we investigated how multiple types of knowledge and beliefs, along with holding an early childhood-related degree and teaching experience, were linked to amounts of early childhood educators’ language and literacy instruction. Quantile regression was used to estimate associations between these variables along a continuum of language and literacy instruction for 222 early childhood educators. In general, low levels of languageand literacy-related instruction were observed; however, the use of quantile regression afforded unique insight into the associations of knowledge, beliefs, education, and teaching experience with instruction when levels of instruction were sufficient. These findings would not have been visible with traditional, linear regression models. Specifically, two types of knowledge were examined: disciplinary-related content knowledge about the structure of language and knowledge for use in teaching language and literacy to young children. Only educators’ disciplinary content knowledge was associated with amount of instruction. Associations between beliefs about language and literacy instruction and amount of instruction were less consistent. Generally, holding an early childhood related degree was positively associated with language and literacy instruction whereas teaching experience was negatively associated with the amount of instruction. Implications for studying educators and understanding the associations among educator characteristics and instruction are discussed. © 2016 Elsevier Inc. All rights reserved.
Scissors-Type Haptic Device Using Magnetorheological Fluid Containing Iron Nanoparticles

The mechanical ability and usefulness of simulation systems can be improved by combining a tactile display with a remote control or medical simulation systems. In this study, a scissors-type haptic device containing magnetorheological fluid (MR fluid) in its fulcrum is developed. We evaluate the mechanical response to the applied voltage and realize the presence of mechanical stimuli when a subject grasps or cuts the corresponding objects. When the magnetic field around the MR fluid is controlled by an electric voltage of 150–500 mV, the torque linearly increases from 0.007 ± 0.000 to 0.016 ± 0.000 N m. The device can provide tactile stimuli with 0.1 s of resolution. We also determined the voltage profiles based on typical force profiles obtained during grasping/cutting processes and evaluated the torque using a mechanical evaluation system. Features of the force profiles related to the soft and sticky feels were reconstructed well.
Protocol of a quantum walk in circuit QED

Implementation of discrete-time quantum walk (DTQW) with superconducting qubits is difficult since on-chip superconducting qubits cannot hop between lattice sites. We propose an efficient protocol for the implementation of DTQW in circuit quantum electrodynamics (QED), in which only $N+1$ qutrits and $N$ assistant cavities are needed for an $N$-step DTQW. The operation of each DTQW step is very quick because only resonant processes are adopted. The numerical simulations show that high-similarity DTQW with the number of step up to $20$ is feasible with present-day circuit QED technique. This protocol can help to study properties and applications of large-step DTQW in experiments, which is important for the development of quantum computation and quantum simulation in circuit QED.
Quantum Mechanics Where Spin is SO(3)

In 2014 Steven Weinberg noted that quantum mechanics can avoid various difficulties, such as the many worlds hypothesis, by taking the quantum states to be density matrices without reference to state vectors. An immediate consequence of Weinberg's idea is that electron spin can be taken to follow SO(3) instead of SU(2). This radical departure from present understanding motivates our exploration of density matrices as a method of going beyond the Standard Model. An important tool for Standard Model calculations is the Feynman path integral formulation of quantum field theory. When the path integral is Wick rotated from time to imaginary time or temperature it becomes a method of cooling down density matrices. While this does not show that one goes beyond the Standard Model by Wick rotation, it does show a close relation between this method of cooling density matrices and quantum field theory of the Standard Model. We explore these ideas and exhibit toy models with particle content and symmetry similar to the Standard Model.
Emulated Inertial Response from Wind Power: Ancillary Service Design and SystemScheduling Considerations

Title Emulated Inertial Response from Wind Power: Ancillary Service Design and System Scheduling Considerations Authors(s) Daly, Pádraig; Ruttledge, Lisa; Power, Michael; Flynn, Damian Publication date 2016-08-26 Conference details 2016 CIGRE Session, Paris, France, 21-26 August 2016 Publisher CIGRE Link to online version http://www.cigre. org/Events/Session/Session-2016 Item record/more information http://hdl.handle. net/10197/8200
Fabrication and Characterization of Pb(Zr,Ti)O3 Microcantilever for Resonance Sensors

A microcantilever beam that includes the Pb(Zr,Ti)O3 (PZT) layer was fabricated. In this cantilever structure, RuO2 conductive oxide thin film was adopted to simplify the structure. Deposition parameters for PZT film were optimized and the etching conditions of Si were studied. From the hysteresis loop of PZT thin film, we found that the remanent polarization (Pr) of PZT thin film increased as the deposition temperature decreased and the post-annealing temperature increased. When the PZT thin films were deposited at 375°C by the radio frequency (RF) magnetron sputtering method and were annealed at 725°C by a rapid thermal annealing (RTA) process, the Pr of PZT thin film reached the maximum value of 11 µC/cm2. The mode of Si etching changed from isotropic one to anisotropic one with the addition of O2 gas in SF6 gas. Using these optimized conditions, 50 µm wide microcantilevers with different lengths from 50 µm to 150 µm were fabricated. It turned out that the measured resonance frequency ranged from 41.6 kHz to 180 kHz and the resonance frequency decreased as the length of cantilever increased.
Spectrum Sensing by Scattering Operators in Cognitive Radio

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Spectrum Sensing by Scattering Operators in Cognitive Radio A Moawad, K Yao, Ali Mansour, Roland Gautier