Miracle-dz/UniFAR-FTUs huggingface dataset:
A Large Scale Semantic Analysis of Verbal Fluency across the Aging Spectrum: Data from the Canadian Longitudinal Study on Aging.

Objectives The present study aimed to characterize changes in verbal fluency performance across the lifespan using data from the Canadian Longitudinal Study on Aging (CLSA). Methods We examined verbal fluency performance in a large sample of adults aged 45-85 (n= 12,686). Data are from the Tracking cohort of the CLSA. Participants completed a computer-assisted telephone interview that included an animal fluency task, in which they were asked to name as many animals as they could in one minute. We employed a computational modeling approach to examine the factors driving performance on this task. Results We found that the sequence of items produced was best predicted by their semantic neighborhood, and that pairwise similarity accounted for most of the variance in participant analyses. Moreover, the total number of items produced declined slightly with age, and older participants produced items of higher frequency and denser semantic neighborhood than younger adults. Discussion These findings indicate subtle changes in the way people perform this task as they age. The use of computational models allowed for a large increase in the amount of variance accounted for in this dataset over standard assessment types, providing important theoretical insights into the aging process.
Favorable effect of glycoprotein IIbIIIa inhibitors among STEMI patients treated with primary PCI and incomplete ST resolution

Abstract Incomplete ST resolution after primary percutaneous coronary interventions (pPCI) in STEMI patients is a well known prognostic marker, associated with the occurrence of microvascular obstruction and increased mortality. The effects of the use of glycoprotein IIbIIIa inhibitors (GPIs) in this peculiar subset of high- risk patients is still unknown. The aim of the present study was to assess whether the GPIs administration would result in improved outcome in ST elevation myocardial infarction (STEMI) patients with incomplete ST resolution (ISTR). All consecutive STEMI patients who underwent pPCI at our hospital between 2005 and 2014 were enrolled (n = 2001). ST resolution was defined as incomplete with a < 70% resolution of initial ST shift. Mortality analyses were performed by Kaplan-Meier curves, multivariable analysis through Cox regressions and propensity matching score. The incidence of ISTR was 29% (n = 592). Among ISTR patients, GPIs use was an independent predictor of better prognosis (HR 0.39, 95% CI 0.16–0.96, p < 0.04). Propensity matched analysis confirmed that the use of GPIs was associated with a lower 30-day (6.1% vs 13.4%, p = 0.02) and 1-year (8.4% vs 15.1%, p = 0.045) mortality. STEMI patients treated with pPCI and presenting ISTR show a poor outcome. The use of GPIs in these patients is associated with improved survival at 30 days and at 1 year; the causes for these favorable effects remain speculative and could be related to the development and evolution of microvascular obstruction.
Modelling of exposure to respirable and inhalable welding fumes at German workplaces

Abstract The International Agency for Research on Cancer classified welding fumes as carcinogenic to humans, and occupational exposure limits should be established to protect welders. The aim of this study is to estimate exposure levels to inhalable and respirable welding fumes by welding process to use them for exposure assessment in epidemiological studies and to derive occupational exposure limits. In total, 15,473 mass concentrations of inhalable and 9,161 concentrations of respirable welding fumes could be analyzed along with welding-related and sampling information, which were compiled in the German database MEGA between 1983 and 2016. In both particle-size fractions, model-based geometric means of the concentrations were estimated by welding process and material for frequently used welding processes adjusted for sampling time and median-centered for calendar years. The inhalable concentrations were approximately twice the respirable concentrations, with medians of 3 mg/m3 (inter-quartile range: 1.2–7.0 mg/m3) and 1.5 mg/m3 (inter-quartile range: < limit of detection −3.8 mg/m3), respectively. The adjusted geometric means of flux-cored arc welding, metal inert and active gas welding, shielded metal arc welding and torch cutting ranged from 0.9 to 2.2 mg/m3 for respirable welding fumes and from 2.3 to 4.7 mg/m3 for inhalable fumes. In both particle-size fractions, geometric means were between 0.1 and 0.9 mg/m3 when performing tungsten inert gas, autogeneous, resistance, laser, and plasma welding or spraying. Results derived from this large dataset are useful for a quantitative exposure assessment to estimate health risks of welders.
Voice Control Tasks on Cognitive Workload and Driving Performance: Implications of Modality, Difficulty, and Duration

The effects of an in-vehicle voice control system (VCS) on cognitive workload and driving performance were evaluated using a driving simulator study with 24 participants. Participants were asked to perform two types of in-vehicle tasks while driving: voice-command based radio and navigation tasks. The tasks were of two difficulty levels (easy, hard) with half of the tasks audio only and the other half audio with a visual display. Cognitive workload was measured using a tactile detection response task (TDRT) and a revised remote detection response task (RDRT). Driving performance was measured using standard deviation of lateral position (SDLP) and standard deviation of vehicle speed. An analysis of covariance for standard deviation of speed was used to examine the effects of VCS display with task duration as the covariate. Three separate mixed models were used to evaluate the variation in SDLP, response time, and misses given VCS tasks and detection response task (DRT) type. No significant differences were observed between TDRT and RDRT, suggesting both methods capture congruent measures of workload and that neither interfere with driving performance. Engagement with each hybrid VCS task was significantly associated with an increase in DRT misses above baseline driving. Additionally, hybrid display tasks had larger variations in vehicle speed and were completed more quickly than equivalent audio only tasks. Increasing values of task duration were associated with greater variation in lateral vehicle position. The results of this study suggest that design of VCSs should consider the modality, temporal components, and difficulty of tasks to reduce cognitive load.
Importance of considering soils in seed transfer zone development: evidence from a study of the native Bromus marginatus.

Seed transfer zones, which define the geographical relationship between adaptive traits and environmental factors, are increasingly used to determine the source populations that can be combined in restoration and revegetation. Climatic variables have been the most commonly used environmental data in transfer zone development, even though soils are also a primary selective force on plants. We assessed the importance of including soils in seed transfer zones using Bromus marginatus, a native grass used for restoration and revegetation in the western United States, as an example. Seeds were collected from 64 populations across Montana and Idaho and grown in a common garden for two years. We assessed among-population variation based on 11 traits related to germination rate, plant size, vigor, inflorescence number, survival, and carbon isotope discrimination (∆13 ), and used this variation to develop seed transfer zone maps using two approaches: (1) a conventional approach, using only climatic variables (climate only) and (2) an expanded approach that included soils and climatic variables (soils + climate). The most influential drivers of trait variation were factors related to soil water availability: soil order, available water content (AWC), and organic carbon levels. Populations from areas with andic soils, which have high soil AWC and soil organic carbon, had low germination, limited first-year survival, low ∆13 , and small seeds. Growing season length and winter temperatures were also predictive of trait variation. In comparison to climate-only models, soils + climate models explained 11% more variance (120% relative increase) for ∆13 and an average of 4.5% more (27% relative increase) for growth traits and survival. The transfer zone map developed using soils + climate differed from the climate-only map in both spatial pattern of ecotypic variation and number of transfer zones; the soils + climate map had more zones and a higher proportion of small (<4 km2 ) transfer zone patches, while the climate-only map had more large patches >37 km2 . Including soils in transfer zone development may identify adaptive trait variation that is obscured by large-scale differences in climate and could improve plant materials used for ecosystem management.
Multistakeholder Etiological Explanation Agreement and Adolescent/Parent Treatment Engagement

Client–therapist consensus has been hypothesized to be an important element of culturally competent care. However, little is known about the relationship between explanatory model agreement and treatment engagement, particularly for services involving adolescents, where both parent and youth perspectives may need to be considered. This longitudinal study collected youth, parent, and therapist survey data on etiological beliefs as well as therapist-rated treatment engagement related to a culturally diverse sample of 285 outpatient mental health service-using youth (aged 12–18, M = 14.06 at Time 1 interview; 40% female). Youth–therapist and parent–therapist agreement on beliefs about the etiology of the youth’s mental health problems were examined in relationship to later treatment engagement. Although parent–therapist agreement was unrelated to parent engagement, youth–therapist coendorsement of etiological beliefs predicted overall youth treatment engagement. In addition, youth–therapist agreement significantly predicted specific aspects of youth engagement: client–therapist interaction, communication/openness, and client’s perceived usefulness of treatment. Results speak to the importance of agreement between therapist and youth upon key issues related to the youth’s problems in mental health treatment settings and support facilitation of consensus as a component of culturally competent care. Differences between findings for youth and parents suggest that therapeutic relationships may vary for different stakeholders, indicating a need to consider individual perspectives and contributions separately.
Using Self-Organizing Maps to Visualize Clusters and Trends in Multidimensional Datasets

A master pattern assembly for providing eyeglass lens circumference shape guidance in an edge grinding machine, suitable for creation of a replacement lens for eyeglasses where one lens is broken and one remains intact. The intact lens is removed from the frame, its optical center is located, and the lens is adhered to a dual-adhesive pad which is also adhered on a side opposite the lens to a body block. The block and pad define coaxial throughgoing bores centered on the optical center of the lens. The bore of the block is then received on a rotatable axis of a conventional edge grinding machine, where the assembly is rotated and the circumference of the intact lens acts as a cam in contact with a pattern follower, controlling circumference formation of a new lens.
Ceramic-Based Composite Membrane with a Porous Network Surface Featuring a Highly Stable Flux for Drinking Water Purification

Highly efficient drinking water purification is still an important challenge for membrane techniques where high flux, high rejection, and low fouling are highly emphasized. In the present work, a porous network surface with carbon nanotubes (CNTs) was in situ constructed on hierarchically-structured mullite ceramic membranes. Interestingly, such a composite structure was demonstrated to effectively remove bacteria from drinking water with a highly stable long-term flux. After membrane structure characterizations, separation performance, such as flux and rejection, was assessed by the purification of bacteria-contaminated drinking water. The results confirmed that the mullite-CNT composite membrane claimed a complete removal of two model bacteria (100% rejection of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus)), driven by a trans-membrane pressure of 0.1 MPa, where a surface sieving mechanism was dominant. A highly stable long-term flux for the 24 h filtration process was achieved, which can be attributed to the porous membrane surface with a special randomly-oriented CNTs network structure, featuring very high three-dimensional open porosity, allowing water to rapidly transport. The bacteria were only trapped on the CNTs network surface via surface filtration, without pore plugging, endowing the mullite-CNT membrane with unprecedentedly low fouling propensity to keep high flux with long-term operation time.
Timing of oral refeeding after acute pancreatitis

Initial treatment of acute pancreatitis is mainly supportive and consists of a nothing by mouth regimen together with intravenous fluid resuscitation and analgesia. Even though nutritional deficits are common in acute pancreatitis, nutritional therapy orally or by tube feeding was long believed to have a negative effect on the progression of the disease. Several studies were published to determine the optimal timing, schedule and type of oral nutrition in acute pancreatitis. They show that early refeeding with a solid diet is safe and may shorten the length of hospital stay. No increased risk of refeeding intolerance, disease recurrence or other adverse events related to a more active refeeding protocol were found. For mild and severe acute pancreatitis the ESPEN Guidelines recommend that oral feeding can be actively attempted once gastric outlet obstruction has resolved and complications are under control. Depending on the clinical course nutrition can be changed to a light full diet and there is no special need for a step-wise progression to a normal full diet according to the German Society for Nutritional Medicine in Cooperation with the Swiss, Austrian and German Societies in their S3Guideline.
Asymmetry in healthy adult knee kinematics revealed through biplane radiography of the full gait cycle

One commonly used criterion in evaluating a patients’ response to knee surgery or rehabilitation is bilateral symmetry. However, the natural symmetry in uninjured healthy adult knee kinematics remains relatively unknown, making it challenging to determine if clinical treatment has adequately restored bilateral symmetry. The primary purpose of this study was to determine the typical side‐to‐side differences in 6 degree of freedom (DOF) knee kinematics over the entire gait cycle in healthy adults using biplane radiography. Six DOF tibiofemoral kinematics were measured during treadmill walking in 19 participants using a validated volumetric model‐based tracking process that matched subject‐specific bone models to biplane radiographs collected at 100 images/s. Average absolute side‐to‐side differences in knee kinematics at foot strike were 1.3 mm or less in translation and 3.8° or less in rotation. Peak side‐to‐side differences in knee kinematics occurred during the swing phase and were up to 2.2 mm in translation and 7.1° in rotation. Dominant versus non‐dominant leg differences were 0.8 mm and 2.8° or less at foot strike and reached maximum values of 0.8 mm and 7.2° over the full gait cycle. Statement of Clinical Significance: This study quantifies the inherent asymmetry of knee kinematics in healthy individuals over the entire gait cycle. The values of asymmetry presented here may serve as a guide for evaluating functional outcomes and restoration of so‐called “normal” kinematics after injury and clinical intervention. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res
Temporal Shifts and Cactus–Beetle Networks in an Intertropical Semiarid Zone in Mexico

Abstract Cactus-dominated semiarid scrubland covers 40% of Mexican territory. This ecosystem is highly dynamic and undergoes drastic changes caused by seasonality. These temporal changes influence saprophagous insect communities associated with Cactaceae species. In this study, we analyzed the beetle community associated with decayed cactus species at the Barranca de Metztitlán Biosphere Reserve in central Mexico. We compared the diversity and composition of beetle communities in rainy and dry seasons; moreover, the network architecture of cactus–beetle interactions was examined. High dominance and abundance were detected in rainy assemblages, whereas the dry season had less abundance but more ecological diversity. A nested structure was found between individual cactus species and beetle species, as well as in an intrapopulation network between fragments of the columnar cacti Isolatocereus dumortieri (Scheidw.) Backeb. (Cactaceae), and beetle species for both seasons (rainy and dry). This finding shows more generalist than specialist beetle species inhabiting cactus species. Further research is still needed to understand whether the presence of these beetle species is determined by microhabitat conditions or the abundance of prey associated with decayed cacti. This is the first step in untangling the complex interactions among cactus–beetle species involved in the decomposition process of cacti in semiarid environments. This study provides evidence of temporal shifts in abundance and diversity patterns of these beetles associated with decayed cacti; furthermore, we did not detect an influence of seasonality on the structure of cactus–beetle interactions.
Risk Factors for Fouling Biomass: Evidence from Small Vessels in Australia

Invasive marine non-indigenous species are a major threat to marine biodiversity and marine related industries. Recreational vessels are recognised as an important vector of non-indigenous species translocation, particularly the secondary translocation of species domestically. This paper reports on a novel application of multilevel modelling and multiple imputation to biomass samples gathered from the hull and other external surfaces of recreational yachts and fishing vessels in order to quantify the relationship between the wet biomass of biofouling and vessel-level characteristics. Unsurprisingly, we find that the number of days since the vessel was last cleaned was strongly related to the wet weight of biomass. The number of days since the vessel was last used was also related to the wet weight of biomass, yet differed depending on the vessel type. Similarly, the median number of trips undertaken by the vessel was related to the wet weight of biomass, and varied according to the type of antifouling paint used by the vessel. The relationship between vessel size, as measured by hull surface area, and wet weight biomass per sample unit area was not significant. In order to reduce the international and domestic spread of invasive species, small vessel owners should use an appropriate type of antifouling paint that suits their vessel’s operational profile, and be encouraged to maintain a maintenance
Integration of Quality Matters as a Graduate Course Assignment.

N ationwide the majority of nursing instructors, whether hospital or academically based, are responsible for teaching various forms of online or hybrid courses. The American Association of Colleges of Nursing reported that more than 60% of associate to bachelor's degree nursingprogramsareoffered at least partially online. There are several benefits associated with teaching in a digital learning environment (DLE) including (a) increasedaccessforstudents tohigh-qualitynursingprograms especially in rural areas, (b) expanding ability to collaborate regardless of geographic area, and (c) improving technological literacy. With a dramatic rise in the use of DLEs, faculty are examining innovative ways to engage in cost-effective, efficient reviews of courses while meeting accrediting agencies requirements for continuous quality improvement. Often when revising and enhancing courses, faculty rely on student satisfaction surveys, which may be biased and unreliable. ManyuniversitieshaveadoptedQualityMatters (QM), a peer-reviewed faculty-centric online course assessment with standards and associated rubric. The QM rubric and review process were developed by MarylandOnline Inc Consortium addressing increasing concerns over the quality of online education. The rubric is useful when assessing DLEs for quality and course structure. When applying the rubric, faculty ensure that course learning objectives, assessment and measurement techniques, instructional materials, course activities, learner interaction, and course technology are correctly aligned and integrated. The rubric contains a set of criteria with assigned point values to determine whether established standards have been met. For a course to be deemed QM certified, all standards must bemet. In essence, the rubric becomes a guide driving course structure, navigation, and component alignment. The rubric can be used as a course quality
Transplacental delivery of genome editing components causes mutations in embryonic cardiomyocytes of mid‐gestational murine fetuses

Genome editing, as exemplified by CRISPR/Cas9, is now recognized as a powerful tool for the engineering of endogenous target genes. It employs only two components, namely, Cas9 in the form of DNA, mRNA, or protein; and guide RNA (gRNA), which is specific to a target gene. When these components are transferred to cells, they create insertion/deletion mutations (indels) within a target gene. Therefore, when fetuses within the uteri of pregnant murine females are exposed to these reagents, fetal cells incorporating them should show mutations in the target gene. To examine a possible genome editing of fetal cells in vivo, we intravenously administered a solution containing plasmid DNA–FuGENE complex to pregnant wild‐type female mice [which had been successfully mated with enhanced green fluorescent protein (EGFP)‐expressing male transgenic mice] on day 12.5 of gestation. The plasmid DNA induces the expression of gRNA, which was targeted at the EGFP cDNA, and that of the Cas9 gene. All fetuses in the pregnant females should express EGFP systemically, since they are heterozygous (Tg/+) for the transgene. Thus, the delivery of CRISPR system targeted at EGFP in the fetuses will cause a reduced expression of EGFP as a result of the genome editing of EGFP genomic sequence. Of the 24 fetuses isolated from three pregnant females 2 days after gene delivery, 3 were found to have reduced fluorescence in their hearts. Genotyping of the dissected hearts revealed the presence of the transgene construct (Cas9 gene) in all the samples. Furthermore, all the three samples exhibited mutations at the target loci, although normal cells were also present. Thus, transplacental delivery of gene editing components may be a useful tool for developing animal models with heart disorder for heart‐related disease research, and gene therapy in congenital heart defects such as hypertrophic cardiomyopathy (HCM). © 2019 IUBMB Life, 9999(9999):1–10, 2019