Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of oral manifestations in COVID‐19: A systematic review

Coronavirus disease 2019 (COVID‐19) is a novel disease caused by a newly identified virus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) causing diverse systemic manifestations. The oral cavity too is not spared and the symptoms appear either independently, concurrently, or sequentially. In view of the rising documented cases of oral lesions of COVID‐19, this systematic review aims to assess the prevalence of oral manifestations in COVID‐19 confirmed individuals. An extensive literature search was conducted in databases like Scopus, Pubmed/Medline, Livivo, Lilacs and Google Scholar and varied oral signs and symptoms were reported as per the PRISMA guidelines. Studies published in English language literature only were included and were subjected to the risk of bias using the Joana Briggs Institute Appraisal tools for prevalence studies, case series and case reports. In a two‐phase selection, 34 studies were included: 21 observational, 3 case‐series and 10 case reports. These observational studies included approximately 14,003 patients from 10 countries. In this review, we explored the most commonly encountered oral and dental manifestations in COVID‐19 and identified that loss of taste acuity, xerostomia and anosmia were frequently reported. Elevated incidence of opportunistic infections like mucormycosis and aspergillosis were reported during the treatment due to prolonged intake of steroids. Immunosuppression and poor oral hygiene led to secondary manifestations like enanthematous lesions. However, it is not clear that oral signs and symptoms are due to COVID‐19 infection itself or are the result of extensive treatment regimen followed [PROSPERO CRD42021258264].
Prospective validation and extension of the Multimodality Prognostic Score for the treatment allocation of pleural mesothelioma patients

Abstract OBJECTIVES Patient allocation to multimodality treatment in patients with malignant pleural mesothelioma remains a challenge. The aim of this study was to validate our previously established Multimodality Prognostic Score (MMPS) (tumour volume before chemotherapy, histological subtype, C-reactive protein before chemotherapy and tumour progression after chemotherapy) and to extend the score with additional blood parameters for better patient outcome. METHODS Patients with histologically proven malignant pleural mesothelioma and curative intended therapy with clinical stage T1–T3 N0–N2 M0 were eligible. The existing MMPS was validated and further additional blood markers (erythrocytes, neutrophils, monocytes, albumin, gamma-glutamyl transferase and alkaline phosphatase) were evaluated for potential incorporation. RESULTS For the validation of the existing MMPS, as the first part of this analysis, 117 patients treated as of September 2011 were included. A total of 88 patients were treated with macroscopic complete resection, whereas 29 patients were treated with palliative or no surgery. Patients treated with macroscopic complete resection and a high MMPS showed statistically significant lower overall survival. In the second part, the extension of the MMPS with additional blood parameters was analysed. Albumin, the only parameter showing evidence for having influence on overall survival, was further added to the extended MMPS. When comparing the performance measures Area under the curve (AUC) and Brier score, the extended score performed better (higher AUC, lower Brier score) than the original MMPS. CONCLUSIONS The extended score with albumin showed improved performance in comparison to the original score. The extended MMPS also may help allocating patients to surgery.
Hygiene in early childhood development centres in low-income areas of Blantyre, Malawi

ABSTRACT Diarrhoeal disease remains a leading cause of death in children in sub-Saharan Africa, attributed to environmental health factors such as inadequate water, sanitation and hygiene (WASH) and food hygiene. This formative study in low-income areas of Blantyre focussed on the practices in Early Childhood Development Centre (ECDCs) environments where children spend a significant amount of time. A mixed-methods approach was applied to identify key hygiene behaviours in ECDCs through; checklist and structured observations (n = 849 children; n = 33 caregivers), focus group discussions (n = 25) and microbiological sampling (n = 261) of drinking water, food handler’s hands, and eating utensils. ECDCs had inadequate WASH infrastructure; coupled with poor hygiene practices and unhygienic environments increased the risk of faecal-oral disease transmission. Presence of E. coli in drinking water confirmed observed poor water handling habits by staff and children. Addressing undesired hygiene practices in ECDCs has the potential to improve the health outcomes of children in low-income settings.
Subjective Fatigue in Children With Unaided and Aided Unilateral Hearing Loss

Fatigue is frequently observed in children with chronic diseases and can affect the quality of life (QoL). However, research in children with unilateral hearing loss (UHL) is scarce. Subsequently, no studies investigated the effects of hearing aids on fatigue in children. This study investigates subjective fatigue and hearing‐related QoL in children with UHL. Furthermore, it evaluates the influence of hearing aids, subject‐specific factors, and respondent‐type on subjective fatigue.
In vivo measurements of lamination patterns in the human cortex

The laminar composition of the cerebral cortex is tightly connected to the development and connectivity of the brain, as well as to function and pathology. Although most of the research on the cortical layers is done with the aid of ex vivo histology, there have been recent attempts to use magnetic resonance imaging (MRI) with potential in vivo applications. However, the high‐resolution MRI technology and protocols required for such studies are neither common nor practical. In this article, we present a clinically feasible method for assessing the laminar properties of the human cortex using standard pulse sequence available on any common MRI scanner. Using a series of low‐resolution inversion recovery (IR) MRI scans allows us to calculate multiple T1 relaxation time constants for each voxel. Based on the whole‐brain T1‐distribution, we identify six different gray matter T1 populations and their variation across the cortex. Based on this, we show age‐related differences in these population and demonstrate that this method is able to capture the difference in laminar composition across varying brain areas. We also provide comparison to ex vivo high‐resolution MRI scans. We show that this method is feasible for the estimation of layer variability across large population cohorts, which can lead to research into the links between the cortical layers and function, behavior and pathologies that was heretofore unexplorable.
Behavioural risk patterns in adolescents with excess weight participating in the PRALIMAP-INÈS trial

Abstract Objective: To investigate clustering of risk behaviours in adolescents with excess weight. Design: Cross-sectional analysis of baseline data from the PRALIMAP-INÈS trial. Information on food frequency consumption (fruit, vegetables, sugary products and beverages), physical activity, sedentary behaviour (week and weekend days), smoking and alcohol consumption (current frequency and intoxication episodes) and socio-demographic data was collected using self-reported questionnaires. Behavioural risk factors were entered as categorical variables in a two-step clustering procedure: multiple correspondence analysis followed by hierarchical clustering. Associations between cluster membership and socio-demographic variables were investigated using multivariable multinomial logistic regression. Setting: French PRALIMAP-INÈS trial. Participants: Adolescents with excess weight. Results: A total of 1391 participants (13–18 years old, 58·2 % female) were included in the analysis, which resulted in the identification of four groups of participants, including, respectively, 543 (39·0 %), 373 (26·8 %), 246 (17·7 %) and 229 (16·5 %) participants. Clusters 1 and 4 showed associations of rather healthy behaviours (high physical activity and low consumption of sugary products; high consumption of fruit and vegetables, respectively), while clusters 2 and 3 showed associations of rather unhealthy behaviours (high sedentary behaviour and low consumption of fruit and vegetables; smoking and alcohol consumption, respectively). Both social status and family structure were associated with cluster membership. Conclusions: Risk behaviour patterns in adolescents with excess weight were clustered in both healthier and less healthy ways, with a complex interplay with socio-demographic factors.
A Distributed Command and Control Simulation System Framework Based on Design Pattern

This paper deals with an application framework of command and control field based on the object-oriented design pattern,clarifies the vertical and horizontal relationship between layers in the framework,and the communication between layers through unified abstract interface reduces the level of coupling between layers.Practice shows that the establishment of the framework has a very important significance on improving software reuse,enhancing system scalability and maintainability,and other aspects.
Smart home system based on internet of things and Kinect sensor

To realize the natural intelligent control of smart home,the Kinect depth sensor is introduced to acquire the depth information and construct the system of human skeleton tracking and speech recognition based on the technology of internet of things(IOT). The system can achieve the intelligent control by user-defined gesture manipulation and speech recognition aimed at all kinds of household articles.The corresponding control commands are transmitted by gateway which is connected with ZIGBEE,RS485 and Wi-Fi.The experiment results show that the presented method can implement the somatosensory interaction control for smart home effectively.
Erythroid‐specific inactivation of Slc12a6/Kcc3 by EpoR promoter‐driven Cre expression reduces K‐Cl cotransport activity in mouse erythrocytes

Investigation of erythrocytes from spontaneous or engineered germ‐line mutant mice has been instrumental in characterizing the physiological functions of components of the red cell cytoskeleton and membrane. However, the red blood cell expresses some proteins whose germline loss‐of‐function is embryonic‐lethal, perinatal‐lethal, or confers reduced post‐weaning viability.
Dose–response efficacy of mulberry fruit extract for reducing post-prandial blood glucose and insulin responses: randomised trial evidence in healthy adults

Abstract Extracts of mulberry have been shown to reduce post-prandial glucose (PPG) and insulin (PPI) responses, but reliability of these effects and required doses and specifications are unclear. We previously found that 1·5 g of a specified mulberry fruit extract (MFE) significantly reduced PPG and PPI responses to 50 g carbohydrate as rice porridge, with no indications of intolerance. The trials reported here aimed to replicate that work and assess the efficacy of lower MFE doses, using boiled rice as the carbohydrate source. Two separate randomised controlled intervention studies were carried out with healthy Indian males and females aged 20–50 years (n 84 per trial), with PPG area under the curve over 2 h as the primary outcome. Trial 1 used doses of 0, 0·37, 0·75, 1·12 and 1·5 g MFE in boiled rice and 0 or 1·5 g MFE in rice porridge. Trial 2 used doses of 0, 0·04, 0·12, 0·37 g MFE in boiled rice. In trial 1, relative to control, all MFE doses significantly decreased PPG (–27·2 to −22·9 %; all P ≤ 0·02) and PPI (–34·6 to −14·0 %, all P < 0·01). Breath hydrogen was significantly increased only at 1·5 g MFE (in rice porridge), and self-reported gastrointestinal symptoms were uniformly low. In trial 2, only 0·37 g MFE significantly affected PPG (–20·4 %, P = 0·002) and PPI (–17·0 %, P < 0·001). Together, these trials show that MFE in doses as low as 0·37 g can reliably reduce PPG and PPI responses to a carbohydrate-rich meal, with no apparent adverse effects.
Subcellular localization of mutant P23H rhodopsin in an RFP fusion knock-in mouse model of retinitis pigmentosa

The P23H mutation in rhodopsin (Rho), the visual pigment protein in rod photoreceptor neurons, is the most common genetic cause of autosomal dominant retinitis pigmentosa (adRP), a retinal disease that causes blindness. Despite multiple studies in animal models, the subcellular details of the fate of misfolded mutant Rho in rod photoreceptors have not been completely defined. We generated a new mouse model of adRP, in which the P23H-Rho mutant allele is fused to the fluorescent protein Tag-RFP-T (P23HhRhoRFP). In heterozygotes, outer segments formed, and WT rhodopsin was properly localized there, but mutant P23H-Rho protein was specifically mislocalized in the inner segments of rods. Despite this cellular phenotype, the P23HhRhoRFP heterozygous mice exhibited only slowly progressing retinal degeneration; in ERG recordings, scotopic a-wave amplitudes were reduced by 24% and 26% at 30 days and 90 days respectively, and the corresponding scotopic b-waves by 18% and 24%. Outer nuclear layer thickness was still 80% of WT at 90 days, but at 364 days had declined to 40% of WT. Transmission electron microscopy revealed greatly expanded membrane lamellae in the inner segment, and by fluorescence imaging, we determined that the mislocalized P23HhRhoRFP was contained in greatly expanded endoplasmic reticulum (ER) membranes. TUNEL staining revealed a slow pace of cell death involving chromosomal endonucleolytic degradation. Quantification of mRNA for markers of ER stress and the unfolded protein response revealed little or no increases in levels of messages encoding the proteins BiP, CHOP, ATF6, XBP1, PERK, Eif2α and Derlin-1, but a decreased level of total Rhodopsin (mouse + human) mRNA levels. The decline in the rate of cell death after an initial burst suggests that P23HhRhoRFP mutant rods undergo an adaptative process that prolongs survival despite gross P23HhRhoRFP protein accumulation in the ER. Because of its slowly progressing nature, and easy visualization of the mutant protein, the P23H-Rho-RFP mouse may represent a useful tool for the future study of the pathology and treatment of P23H-Rho and adRP.
A compliment's cost: How positive responses to non-traditional choices may paradoxically reinforce traditional gender norms.

In times of societal change, like changes in gender roles, one may compliment men deciding to spend more time on childcare, or women pursuing a job higher up, to support their pioneering behaviour. However, we predict that while compliments may communicate appreciation of someone's behaviour, they simultaneously communicate that a norm has been breached, and thus that the behaviour is not considered 'normal'. In four studies (total N = 821), we show that men receive more compliments for reducing work hours for childcare than women (Study 1). Moreover, compliments (compared to neutral responses) signal more descriptive norm deviance, and this has downstream consequences for perceptions of the target's gender belonging and decision doubt and for perceived societal norms (Studies 2-4). Together, these findings contribute to our understanding of normative communication patterns as well as potential paradoxical reinforcement of gender norms through compliments.
Competition for refuelling rather than cyclic re-entry initiation evident in germinal centers

Antibody affinity maturation occurs in germinal centers (GCs) through iterative rounds of somatic hypermutation and proliferation in dark zones (DZs) and selection in light zones (LZs). GC B cells exit cell cycle a number of hours before entering LZs; therefore, continued participation in responses requires that they subsequently reenter cell cycle and move back to DZs, a process known as cyclic reentry. Affinity enhancements are thought to arise by B cells having to compete to initiate cyclic reentry each time they enter LZs, with T cell help being a major determinant; however, direct proof is lacking. Using Fucci2 mice, we confirmed an association between B cell receptor affinity and the first step of cyclic reentry, S phase initiation from a resting LZ state. However, neither T cell ablation nor MHCII deletion prevented resting LZ cells from reentering cell cycle, and this late G1-S transition was also not detectably restricted by competition. In contrast, using BATF induction as exemplar, we found that T cells “refueled” LZ cells in an affinity-dependent manner that was limited by both competition and cells’ intrinsic antigen-acquiring abilities. Therefore, cyclic reentry initiation and B cell refueling are independently regulated in GCs, which may contribute to permitting cells of different competencies to be sustained alongside each other and allow T cell support to be provided across a dynamic range commensurate with affinity. We speculate that this less binary selection mechanism could help GCs nurture complex antibody maturation pathways and support the clonal diversity required for countering fast-evolving pathogens. Description Germinal center B cells compete to be refueled by T cells but not for cyclic reentry initiation during affinity maturation. When T cells aren’t so helpful Germinal center (GC) B cells undergo rounds of somatic hypermutation and clonal selection, resulting in increased antibody affinity. Clonal selection is incompletely understood but may involve GC B cells being instructed to reenter cell cycle and move from light zones to dark zones, known as “cyclic reentry. ” Long et al. tested key assumptions of cyclic reentry models using Fucci2 cell cycle reporter mice in combination with approaches to modulate selection inputs. T cell depletion and MHCII deletion in GC B cells identified that T cell help is not limiting or necessary for initiation of cyclic reentry. Instead, the authors found that T cell help “refueled” GC B cells, which likely prepares them for a better life in the dark zone. These results provide new context into how GC B cells are selected.
Taxonomy of Asteroids From the Legacy Survey of Space and Time Using Neural Networks

The Legacy Survey of Space and Time (LSST) is one of the ongoing or future surveys, together with the Gaia and Euclid missions, which will produce a wealth of spectrophotometric observations of asteroids. This article shows how deep learning techniques with neural networks can be used to classify the upcoming observations, particularly from LSST, into the Bus-DeMeo taxonomic system. We report here a success ratio in classification up to 90.1% with a reduced set of Bus-DeMeo types for simulated observations using the LSST photometric filters. The scope of this work is to introduce tools to link future observations into existing Bus-DeMeo taxonomy.
Moral Disengagement, Social Norms, and Motivational Profiles Influence Attitudes Toward Doping Among Spanish Athletics Coaches

Coaches strongly influence athletes' attitudes toward doping and can shape athlete's beliefs, behaviors, and decisions to be for or against doping. Coached-centered studies examining multiple factors affecting coaches' doping attitudes and behavior are scarce. The aim of this study was to analyze for the first-time attitudes toward doping in athletics coaches using the Sport Drug Control Model (SDCM) as a theoretical framework. A secondary aim was to determine the factors in the model predicting attitude and susceptibility toward doping. A cross-sectional study was carried out using a sample consisting of 201 Spanish athletics competitive level coaches from whom 11.4% were female. Participants completed a cross-sectional online survey. Structural equation modeling showed a good fitness of the SDCM. Positive attitudes toward doping predicted high susceptibility to doping (β = 0.39, p < 0.001). Moral disengagement (β = 0.58, p < 0.001), descriptive norms (β = 0.42, p = 0.001), ego-oriented goals (β = 0.34, p < 0.05), and self-efficacy to refrain from doping (β = 0.26, p < 0.05) displayed a significant influence on attitudes toward doping. Self-reported doping prevalence in coaches was 4.5%. These variables should be considered when designing anti-doping research projects and educational programs aiming at modifying coaches' attitudes toward doping. It is recommended to focus more efforts on coaches, without putting aside the athletes, and therefore turn coaches into reliable doping prevention factors. To this end, it is necessary to enhance scientific research and then develop, implement, and promote more educational programs targeting coaches, on a mandatory basis while covering the specific needs of coaches so that they can perform their role as anti-doping educators in an effective, committed, and proactive manner.
Treatment With Multi-Species Probiotics Changes the Functions, Not the Composition of Gut Microbiota in Postmenopausal Women With Obesity: A Randomized, Double-Blind, Placebo-Controlled Study

Probiotics are known to regulate host metabolism. In randomized controlled trial we aimed to assess whether interventions with probiotic containing following strains: Bifidobacterium bifidum W23, Bifidobacterium lactis W51, Bifidobacterium lactis W52, Lactobacillus acidophilus W37, Levilactobacillus brevis W63, Lacticaseibacillus casei W56, Ligilactobacillus salivarius W24, Lactococcus lactis W19, and Lactococcus lactis W58 affect gut microbiota to promote metabolic effects. By 16S rRNA sequencing we analyzed the fecal microbiota of 56 obese, postmenopausal women randomized into three groups: (1) probiotic dose 2.5 × 109 CFU/day (n = 18), (2) 1 × 1010 CFU/day (n = 18), or (3) placebo (n = 20). In the set of linear mixed-effects models, the interaction between pre- or post-treatment bacterial abundance and time on cardiometabolic parameters was significantly (FDR-adjusted) modified by type of intervention (26 and 19 three-way interactions for the pre-treatment and post-treatment abundance, respectively), indicating the modification of the bio-physiological role of microbiota by probiotics. For example, the unfavorable effects of Erysipelotrichi, Erysipelotrichales, and Erysipelotrichaceae on BMI might be reversed, but the beneficial effect of Betaproteobacteria on BMI was diminished by probiotic treatment. Proinflammatory effect of Bacteroidaceae was alleviated by probiotic administration. However, probiotics did not affect the microbiota composition, and none of the baseline microbiota-related features could predict therapeutic response as defined by cluster analysis. Conclusions: Probiotic intervention alters the influence of microbiota on biochemical, physiological and immunological parameters, but it does not affect diversity and taxonomic composition. Baseline microbiota is not a predictor of therapeutic response to a multispecies probiotic. Further multi-omic and mechanistic studies performed on the bigger cohort of patients are needed to elucidate the cardiometabolic effect of investigated probiotics in postmenopausal obesity.