Miracle-dz/UniFAR-FTUs huggingface dataset:
Novel structures derived from 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazole as anti-Helicobacter pylori agents, Part 1.

2-[[(2-Pyridyl)methyl]thio]-1H-benzimidazoles (2, sulfides) exhibit antibacterial properties that are selective for Helicobacter spp. , but they also have an inherent susceptibility to metabolic oxidation to furnish 2-[[(2-pyridyl)methyl]sulfinyl]-1H-benzimidazoles (1), which act as proton pump inhibitors (PPIs). We have discovered five compounds with retained antibacterial potency and selectivity in which the overall framework of the sulfides 2 could be kept intact while structural modifications were made to remove PPI activity. These compounds, 2-[((2-methyl-3-(2-(2-(2-methoxyethoxy)ethoxy)ethylthio)phenyl)methyl)thio]-1H-benzimidazole (79), 2-[((2-methyl-3-(2-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxy)ethylthio)phenyl)methyl)thio]-1H-benzimidazole (80), 2-[((2-methyl-3-((2-morpholino)ethylthio)phenyl)methyl)thio]-1H-benzimidazole (86), 2-[[[2-methyl-3-[2-(2-methyl-5-nitroimidazol-1-yl)ethylthio]phenyl]methyl]thio]-1H-benzimidazole (88), and 2-[[[2-methyl-3-[2-(1,2,4-triazol-1-yl)ethylthio]phenyl]methyl]thio]-1H-benzimidazole (89), had minimum bactericidal concentrations (MBCs) of 0.5, 0.5, 1, 2, and 4 microg/mL, respectively. The reported compounds are bactericidal with MBCs within 1 order of magnitude of MBCs of clinically used antimicrobials such as clarithromycin (0.1 microg/mL) or metronidazole (2-4 microg/mL) but differ from these inasmuch that they have an extremely narrow spectrum activity and appear to be species specific.
Demonstration of Insulin Transformation Products in Insulin Vials by High-Performance Liquid Chromatography

Objective To assess the importance of temperature, light, agitation, and regular withdrawal of insulin on the rates of appearance of three groups of insulin transformation products (ITPs) in vials of human and beef soluble insulin. Research Design And Methods Twelve insulin-treated patients (6 receiving human soluble insulin, 6 receiving beef soluble insulin) participated in the study. Reverse-phase high-performance liquid chromatography was used to measure ITP in serial samples from vials stored in various laboratory environments or issued to patients. Vials in the laboratory were analyzed on nine occasions over 26 wk; those issued to patients were analyzed weekly. Results Results were expressed as rates of change (% total protein/wk). Except for human insulin stored at 4°C, sampling did not accelerate transformation. Storage at higher temperatures caused more rapid transformation to all ITP groups, and human insulin was more susceptible than beef insulin. Exposure to light accelerated transformation mainly to group 3 ITP. Fibrillation occurred in beef but not human insulin carried in a shirt pocket. Results from patients' vials were consistent with reported storage conditions. Conclusions All three ITP groups form in human and beef soluble insulin. Their rate of production is a function of temperature and light exposure. Differences between the two insulins were probably due to differences in formulation. Patients should be discouraged from hoarding vials and storing insulin in direct sunlight. One or more ITPs could contribute to the residual immunogenicity of modern insulin preparations.
Recursos Personales Positivos en la Relación con el Paciente: las Estrategias de Regulación Emocional

espanolEl personal sanitario se enfrenta continuamente en su ambito laboral a grandes presiones, en muchos casos, relacionadas con altas demandas emocionales por la relacion profesional-paciente. En este contexto, las estrategias de regulacion emocional se muestran como un importante recurso del personal sanitario para el manejo de las emociones hacia objetivos deseables. En el presente articulo se expone una revision sobre la influencia de las emociones en el contexto laboral, los distintos modelos y estrategias de regulacion emocional y como influyen sobre el bienestar, la salud y la relacion del personal sanitario con los pacientes. Como valor anadido, se compara la eficacia de las distintas estrategias de regulacion y como afectan de manera diferencial a las relaciones entre los profesionales sanitarios y en la relacion profesional-paciente. EnglishHealth workers are continually faced to great pressure, often related to high emotional demands of the caregivers-patient relationship in the workplace. In this context, emotion regulation strategies are shown as an important personal resource to manage emotions toward desirable goals. This article presents a review of the literature about the emotional influence in job context, the different models and strategies of emotional regulation and how they influence on well-being, health and professional-patient relationship. In addition, we compare the efficacy of different regulation strategies and their differential effect on colleague and patient relationships.
Intramedullary Nailing of Acute Femoral Shaft Fractures Using Manual Traction without a Fracture Table

Summary: Intramedullary (1M) nails were prospectively placed in 32 consecutive femoral shaft fractures without the use of a fracture table. All fractures were reduced using manual traction. Pathologic and nonacute fractures and those requiring a reconstruction nail were excluded. The results are compared with results of two prior study groups from this institution that underwent IM nailing with or without a fracture table using a femoral distractor. Ten patients had unstable spine or pelvis fractures. Four nailings followed exploratory laparotomy. Twelve patients underwent two or more procedures on the lower extremities under the same preparation and drape. Six fractures were open. Sixty-seven percent of results were anatomic, 27% had <5 mm lengthening/shortening or <5° varus/valgus, and 7% had >5 mm lengthening/shortening or <5° varus/valgus. Average operative time was 95 min. No complications occurred that were attributable to the technique. Compared with the prior study groups, no statistical difference in the fracture types or results was found. However, operative time was significantly less in the manual traction group (p < .05). We feel that this technique is a safe, simple, and effective alternative to using a fracture table. The technique is especially useful in the polytrauma patient, significantly decreasing anesthestic time
Fast Fine-Grained Image Classification via Weakly Supervised Discriminative Localization

Fine-grained image classification is to recognize hundreds of subcategories in each basic-level category. Existing methods employ discriminative localization to find the key distinctions between similar subcategories. However, they generally have two limitations: 1) discriminative localization relies on region proposal methods to hypothesize the locations of discriminative regions, which are time-consuming and the bottleneck of improving classification speed and 2) the training of discriminative localization depends on object or part annotations which are heavily labor-consuming and the obstacle of marching toward practical application. It is highly challenging to address the two limitations simultaneously, while existing methods only focus on one of them. Therefore, we propose a weakly supervised discriminative localization approach (WSDL) for fast fine-grained image classification to address the two limitations at the same time, and its main advantages are: 1) multi-level attention guided localization learning is proposed to localize discriminative regions with different focuses automatically, without using object and part annotations, avoiding the labor consumption. Different level attentions focus on different characteristics of the image, which are complementary and boost classification accuracy and 2) $n$ -pathway end-to-end discriminative localization network is proposed to improve classification speed, which simultaneously localizes multiple different discriminative regions for one image to boost classification accuracy, and shares full-image convolutional features generated by a region proposal network to accelerate the process of generating region proposals as well as reduce the computation of convolutional operation. Both are jointly employed to simultaneously improve classification speed and eliminate dependence on object and part annotations. Comparing with state-of-the-art methods on two widely used fine-grained image classification data sets, our WSDL approach achieves the best accuracy and the efficiency of classification.
Quicker, Easier, and Cheaper? The Promise of Automated Hand Hygiene Monitoring

There are several reasons why surveillance of hand hygiene performance is a crucial part of successful promotion strategies. These can be conceptualized according to the end-user of the data: infection control professionals; healthcare workers (HCWs); researchers; and external stakeholders, such as governmental and nongovernmental accreditation and benchmarking bodies and the general public. Each of these groups comes to hand hygiene performance data with different expectations and preconceptions and will use it for different purposes. Thus, one of the challenges of collecting such data is to do it in such a way that it satisfies the specifications of all interested parties as much as possible. Boyce provides a thorough and balanced overview of the current state of hand hygiene monitoring. At a time when the field of hand hygiene promotion is maturing rapidly and infection control professionals are facing a vast range of options for monitoring performance in their hospital, this review comes as a timely and welcome summary and answers many common questions in addition to demystifying some newer technologies.
Serum levels of clomipramine and desmethylclomipramine and clinical improvement in panic disorder

Several placebo-controlled trials have shown the effcacy of clomipramine (CMI) in panic disorder. However, none has investigated the relationship between CMI, and desmethylclomipramine (DCMI) plasma levels, and outcome. In this trial, 41 patients meeting the DSM-III-R criteria for panic disorder with/without agoraphobia received 50-200 mg of CMI daily in a single-blind, flexible dose regimen for 14 weeks. At the end of treatment, 97% of the patients were free of panic attacks. Patients were classified into two groups of improvement according to the panic symptom items of the `Patient-Rated Anxiety Scale'. A repeated-measures analysis of variance suggested a significant association between outcome and serum DCMI level/daily dose ratio as well as total serum level/daily dose. Patients with intense improvement showed DCMI and total serum levels lower than those with moderate improvement. The results indicate the importance of monitoring clomipramine and desmethylclomipramine serum levels in this disorder.
Draft Genome Sequence of Carbaryl-Degrading Soil Isolate Pseudomonas sp. Strain C5pp

ABSTRACT We report the draft genome sequence of carbaryl-degrading Pseudomonas sp. strain C5pp. Genes encoding salicylate and gentisate metabolism, large amounts of oxygenase, nitrogen metabolism, and heavy metal tolerance were identified. The sequence will provide further insight into the biochemical and evolutionary aspects of carbaryl degradation.
The efficiency measurement of parallel production systems: a non-radial data envelopment analysis model

Problem statement: Data Envelopment Analysis (DEA) is a non-parametric technique for measuring the relative efficiency of a set of production systems or Decision Making Units (DMU) that have multiple inputs and outputs. Sometimes, DMUs have a parallel structure, in which systems composed of parallel units work individually; the sum of their own inputs/outputs is the input/output of the system. For this type of system, conventional DEA models treat each DMU as a black box and ignore the performance of its units. Approach: This study introduces a DEA model in Slacks-Based Measure (SBM) formulation which considers the parallel relationship of the units within the system in measuring the efficiency of the system. Under this framework, the overall efficiency of the system is expressed as a weighted sum of the efficiencies of its units. Results: As an SBM model, the proposed model is non-radial and is suitable for measuring the efficiency when inputs and outputs may change non-proportionally. A theoretical result shows that if any unit of a parallel system is inefficient then the system is inefficient. Conclusion: This study introduces a non-radial DEA model, takes into account the operation of individual components within the parallel production system, to measure the overall efficiency as well as the efficiencies of sub-processes. This helps the decision makers recognize inefficient units and make later improvements.
G protein-coupled receptor oligomerization for what?

Although the G protein-coupled receptor (GPCR) oligomerization has been questioned during the last decade, under some premises the existence of a supramolecular organization of these receptors begins now to be widely accepted by the scientific community. Indeed, GPCR oligomers may enhance the diversity and performance by which extracellular signals are transferred to the G proteins in the process of receptor transduction, although the mechanism that underlie this phenomenon remains still unexplained. Recently, a trans-conformational switching model has been proposed as a mechanism allowing direct inhibition of receptor activation. Thus, heterotropic receptor–receptor allosteric regulations are behind the GPCR oligomeric function. Accordingly, we revise here how GPCR oligomerization impinge in several important receptor functions like biosynthesis, plasma membrane diffusion or velocity, pharmacology and signaling. Overall, the rationale of receptor oligomerization might lie in the cellular need of sensing complex extracellular signals and to translate into a simple computational mode.
Daily Exercise Does Not Prevent Recurrence of Benign Paroxysmal Positional Vertigo

Objective: The purpose of this study was to analyze if a daily routine of self-canalith repositioning procedure (CRP) will increase the time to recurrence and reduce the rate of recurrence of benign paroxysmal positional vertigo (BPPV). Study Design: Prospective study, nonrandomized control group. Setting: Outpatient clinic. Patients: Thirty-nine patients diagnosed with posterior canal BPPV successfully treated with the CRP. Based on a convenience sample, 17 (44%) patients were assigned to the treatment group, whereas 22 (56%) were assigned to the no-treatment group. The number of subjects lost at the time of follow-up were 5 (29.4%) of the treatment group and 2 (9%) of the no-treatment group. Interventions: Patients assigned to the treatment group performed the self-CRP daily, whereas those assigned to the no-treatment group performed no exercises. Patients were followed for up to 2 years. Main Outcome Measures: The main outcome measures were the rate of recurrence of BPPV and the time for BPPV to recur. Results: Of the 39 subjects, symptoms recurred in 16 (41%) of the total population, 6 (35%) of 17 of the treatment group, and 10 (46%) of 22 of the no-treatment group. There was no difference in the frequency of recurrence (Pearson &khgr;2; p = 0.522) or the time to recurrence (survival analysis; log-rank test; p = 0.242). Conclusion: Our results suggest that a daily routine of the self-CRP does not affect the time to recurrence and the rate of recurrence of posterior canal-BPPV.
A Semi-Automatic Approach for Eliciting Cloud Security and Privacy Requirements

Cloud computing provides a wide range of services to organisations in a flexible and cost efficient manner. Nevertheless, inherent cloud security issues make organisations hesitant towards the migration of their services to cloud. In parallel, the cloud service-oriented nature requires a specific and more demanding description of the business functional requirements intended for migration. Organisations need to transform their functional requirements based on a specific language, taking into account the respective non-functional requirements of the migrating services. Thus, the need for an approach that will holistically capture organisations' security and privacy requirements and transform them to cloud service requirements is immense. To this end, this paper presents an approach that takes as input abstract security and privacy requirements and produces through a semi-automatic process various alternative implementation options for cloud services. To achieve that a series of model transformations are utilised in order to create a mapping between the organisational and the operational level of the system's analysis.
TWO NEW SPECIES OF PSEUDOHAPLADENA YAMAGUTI, 1952 (DIGENEA: WARETREMATIDAE) FROM MUGILID FISH FROM THE TAIWAN STRAITS, CHINA

Two new species of Pseudohapladena Yamaguti, 1952 (Digenea: Waretrematidae) are described. Pseudohapladena megaorchis n. sp. was obtained from the intestine of Mugil engeli (Bleeker) (Mugilidae), and Pseudohapladena lizae n. sp. from the intestine of Liza carinatus (Cuvier and Valenciennes) (Mugilidae). Pseudohapladena megaorchis is the most closely related in general morphology to Pseudohapladena scatophagi Yamaguti, 1952, but differs from the latter in the position of the hermaphroditic sac, and in the nature and distribution of the vitellaria. Features of P. lizae distinguishing it from other species of the genus include the shorter uterus, which contains only 1 egg, and the lesser extent of the vitellaria.
Measurement of gene expression by translational coupling: effect of copy mutations on pT181 initiator synthesis.

We have prepared and analyzed two types of gene fusion between the replication initiator gene, repC, and the reporter gene, blaZ, in order to investigate the relationship between pT181 plasmid copy number and RepC initiator protein production. A series of pT181 copy mutant plasmids, with copy numbers ranging from 70 to 800 copies per cell, were analyzed. In one type of gene fusion used in this study, blaZ was translationally coupled to the C‐terminal end of the repC coding sequence such that native forms of both proteins were produced. This gene fusion arrangement, which permitted monitoring of RepC production (as BlaZ activity) by plasmids using the protein for their own replication, demonstrated a linear relationship, with one exception, between RepC production and plasmid copy number over a 20‐fold range. In the second type of fusion, blaZ was translationally fused to the C‐terminal end of repC. As the translational fusion did not produce active RepC protein, the fusion‐containing pT181 derivatives were maintained in a strain which provided RepC in trans, and were thus analyzed at constant copy number. In contrast to previous analyses of this type, our translational fusion constructs expressed repC at levels proportional to the copy numbers of the plasmids from which the fusions were prepared. Using these data, we have calculated a minimum figure for the number of RepC molecules synthesized per replication event.
Clotting activation after oral anticoagulant therapy discontinuation: a risk factor for recurrent venous thromboembolism

A hypercoagulable state has been reported in some patients treated for venous thromboembolism (VTE) after oral anticoagulant treatment (OAT) discontinuation. It is unclear whether this is a risk factor for thrombosis recurrence. We investigated 139 patients with VTE and followed them up for a median of 20.5 months (6–90 months) to evaluate whether fragment 1 + 2 (F1 + 2) plasma levels are prognostic for VTE recurrence and to confirm clotting activation after OAT withdrawal. Fourteen patients had recurrences during the follow-up. F1 + 2 was measured the day before OAT withdrawal (T0) and 4 weeks later (T1) and its levels were similar in patients with spontaneous VTE versus those with transient risk factors for VTE. F1 + 2 levels increased from T0 to T1 (P < 0.0005). At T1, F1 + 2 values were significantly higher in patients with recurrence than in those without (P < 0.005). The negative predictive value of normal levels of F1 + 2 at T1 was 95%. In carriers of thrombophilic conditions no correlation was found between F1 + 2 levels and VTE recurrence. The results of this study confirm clotting activation after OAT discontinuation and suggest that higher F1 + 2 plasma levels are an independent risk factor for VTE recurrence.
A 3.5pJ/bit 8-tap-feed-forward 8-tap-decision feedback digital equalizer for 16Gb/s I/Os

In this paper, we present a digital equalizer for 16Gb/s backplane I/Os which consumes only 3.5pJ/bit for an 8-tap FFE and 4+4 tap DFE operation. Several design choices were chosen to enable low power consumption at high speed. First, the FFE leverages parallelism to lower the supply voltage, while the DFE runs from a higher supply to close the feedback loop. Second, the FFE uses distributed arithmetic to reduce the number of required additions. Third, the DFE taps leave a window of four equalizer taps, which are covered by the FFE, in order to close the timing. Finally, a custom digital design style was chosen, which enabled the optimization of critical blocks and wires. At 0.6V supply, the FFE was measured to consume 1pJ/bit, while the DFE consumes 1.6pJ/bit at 0.9V while running at 16Gb/s.
SYNTHESIS Relationships am ong net primary productivity , nutrients and climate in tropical rain forest : a pantropical analysis

Tropical rain forests play a dominant role in global biosphere-atmosphere C O 2 exchange. A lthough climate and nutrient availability regulate net primary production (NPP) and decomposition in aU terrestrial ecosystems, the nature and extent o f such controls in tropical forests remain poorly resolved. We conducted a meta-analysis o f carbon-nutrient-chmate relationships in 113 sites across the tropical forest biome. O ur analyses showed that mean annual temperature was the strongest predictor o f aboveground N PP (ANPP) across aU tropical forests, but this relationship was driven by distinct temperature differences between upland and lowland forests. Within lowland forests (< 1 0 0 0 m), a regression tree analysis revealed that foliar and sod-based measurements o f phosphorus (P) were the only variables that explained a significant proportion o f the variation in ANPP, although the relationships were weak. However, foliar P, foliar nitrogen (N), litter decomposition rate (k), sod N and sod respiration were ad directly related with total surface (0-10 cm) soil P concentrations. O ur analysis provides some evidence that P availabdity regulates N PP and other ecosystem processes in lowland tropical forests, but more importantly, underscores the need for a series o f large-scale nutrient manipulations — especially in lowland forests to elucidate the m ost im portant nutrient interactions and controls. Cory C. Cleveland,^* Alan R. Townsend,^ Philip Taylor,^ Silvia Alvarez-Clare,'^ M ercedes M. C. Bustamante,^ G eorge Chuyong,® Solom on Z. Dobrowski,^ Pauline Grierson,® Kyle E. Harms,® Benjamin Z. Moulton,^® Alison Marklein,^® William P arton," Stephen Porder,^^ Sasha C. Reed,^® Carlos A. Sierra,^'^ W hendee L. Silver,^® Edmund V. J. Tanner^® and William