Miracle-dz/UniFAR-FTUs huggingface dataset:
QoS Issues in Web Services

Quality of service (QoS) is a combination of several qualities or properties of a service, such as: availability is the percentage of time that a service is operating; security properties include the existence and type of authentication mechanisms the service offers, confidentiality and data integrity of messages exchanged, nonrepudiation of requests or messages, and resilience to denial-of-service attacks; response time is the time a service takes to respond to various types of requests; Response time is a function of load intensity, which can be measured in terms of arrival rates (such as requests per second) or number of concurrent requests. QoS takes into account not only the average response time, but also the percentile of the response time; and throughput is the rate at which a service can process requests. QoS measures can include the maximum throughput or a function that describes how throughput varies with load intensity. The QoS measure is observed by Web services users. These users are not human beings but programs that send requests for services to Web service providers. QoS issues in Web services have to be evaluated from the perspective of the providers of Web services and from the perspective of the users of these services.
Design of image encryption algorithm based on different chaotic mapping

Converting information (data) from its original form to another form is known as encryption as in order to access rising the information protection. The encryption created on chaos theory includes some dynamic methods to improve the protection of image encryption. In this work, encryption image is achieved by using a different chaotic mapping. The original image is split into blocks and then different chaotic maps are employed for five stages of proposed encryption algorithm. First, the cubic map is employed to permute the pixels which contained within the blocks. Second, Henon map has been used to diffuse the permuted pixels. Third, a quadratic map has been worked to permute the blocks. Fourth, a logistic map has been used to permute all the pixels entire an image. Finally, XOR Henon map has been worked to diffuse the permuted image. High-efficiency for encryption quality algorithm has been shown by the performance analysis of proposed algorithm.
Investigating the Interaction between the Neonatal Fc Receptor and Monoclonal Antibody Variants by Hydrogen/Deuterium Exchange Mass Spectrometry*

The recycling of immunoglobulins by the neonatal Fc receptor (FcRn) is of crucial importance in the maintenance of antibody levels in plasma and is responsible for the long half-lives of endogenous and recombinant monoclonal antibodies. From a therapeutic point of view there is great interest in understanding and modulating the IgG–FcRn interaction to optimize antibody pharmacokinetics and ultimately improve efficacy and safety. Here we studied the interaction between a full-length human IgG1 and human FcRn via hydrogen/deuterium exchange mass spectrometry and targeted electron transfer dissociation to map sites perturbed by binding on both partners of the IgG–FcRn complex. Several regions in the antibody Fc region and the FcRn were protected from exchange upon complex formation, in good agreement with previous crystallographic studies of FcRn in complex with the Fc fragment. Interestingly, we found that several regions in the IgG Fab region also showed reduced deuterium uptake. Our findings indicate the presence of hitherto unknown FcRn interaction sites in the Fab region or a possible conformational link between the IgG Fc and Fab regions upon FcRn binding. Further, we investigated the role of IgG glycosylation in the conformational response of the IgG–FcRn interaction. Removal of antibody glycans increased the flexibility of the FcRn binding site in the Fc region. Consequently, FcRn binding did not induce a similar conformational stabilization of deglycosylated IgG as observed for the wild-type glycosylated IgG. Our results provide new molecular insight into the IgG–FcRn interaction and illustrate the capability of hydrogen/deuterium exchange mass spectrometry to advance structural proteomics by providing detailed information on the conformation and dynamics of large protein complexes in solution.
Patient Data Prioritization in the Cross-Layer Designs of Wireless Body Area Network

In Wireless Body Area Network (WBAN), various biomedical sensors (BMSs) are deployed to monitor various vital signs of a patient for detecting the abnormality of the vital signs. These BMSs inform the medical staff in advance before the patient's life goes into a threatening situation. In WBAN, routing layer has the same challenges as generally seen in WSN, but the unique requirements of WBANs need to be addressed by the novel routing mechanisms quite differently from the routing mechanism in Wireless Sensor Networks (WSNs). The slots allocation to emergency and nonemergency patient's data is one of the challenging issues in IEEE 802.15. 4 and IEEE 802.15. 6 MAC Superframe structures. In the similar way, IEEE 802.15. 4 and IEEE 802.15. 6 PHY layers have also unique constraints to modulate the various vital signs of patient data into continuous and discrete forms. Numerous research contributions have been made for addressing these issues of the aforementioned three layers in WBAN. Therefore, this paper presents a cross-layer design structure of WBAN with various issues and challenges. Moreover, it also presents a detail review of the existing cross-layer protocols in the WBAN domain by discussing their strengths and weaknesses.
Use of Indirect Excretory/Secretory Enzyme-Linked Immunosorbent Assay (ES-ELISA) for the Diagnosis of Natural Fasciola hepatica Infection in Eosinophilic and Non-Eosinophilic Cattle from Eastern Turkey

The aim of this study was to investigate fasciolosis in a group of eosinophilic and non-eosinophilic cattle in eastern Turkey. All the cattle were examined for antibodies against F. hepatica by modified indirect excretory/secretory enzyme-linked immunosorbent assay (ES-ELISA). Of the 1200 cattle tested, 164 (13.6%) were found to be eosinophilic by absolute eosinophil counts. Out of the 164 eosinophilic cattle, 121 (73.7%) were found to be positive for fasciolosis by indirect ES-ELISA, while the rate was only 35% among the non-eosinophilic group (P < 0.001). Our data indicate that parasitic infections should be considered an important cause of eosinophilia, particularly in fasciolosis, and the indirect ES-ELISA is useful as a screening test to examine anti-F. hepatica antibodies for the diagnosis of fasciolosis in cattle.
Extraction and implementation of muscle synergies in neuro-mechanical control of upper limb movement

This work faces the redundancy problem, a central concern in robotics, in a particular force-producing task by using muscle synergies to simplify the control. We extracted muscle synergies from human electromyograph signals and interpreted the physical meaning of the identified muscle synergies. Based on the human analysis results, we hypothesized a novel control framework that can explain the mechanism of the human motor control. The framework was tested in controlling a pneumatic-driven robotic arm to perform a reaching task. This control method, which uses only two synergies as manipulated variables for driving antagonistic pneumatic artificial muscles to generate desired movements, would be useful to deal with the redundancy problem; thus, suggesting a simple but efficient control for human-like robots to work safely and compliantly with humans. Graphical Abstract
Implementing Prioritized Reasoning in Logic Programming

A torquer/thruster with a hydrostatically actuated chuck assembly having an elastomeric bladder that is fitted about a cylindrical collet into which a flexible roof drill is received. The collet is formed with a series of spaced slits that are disposed in helical paths, portions of the collet between the slits drivingly engage the drill shaft when the bladder is urged against the collet. The collet and bladder are mounted for rotational movement within a piston assembly that is constrained for limited longitudinal movement and fixed against rotational movement. The collet and bladder are moved longitudinally by the piston assembly for applying thrust to the roof drill and are rotatably driven by a rotary driver for applying torque to the roof drill. A pair of driven biased members engage the shaft and provide thrust assistance and retraction of the roof drill.
A Sociometric Investigation of Sex and Race Peer Preferences Among Deaf Adolescents

This study investigated sex and race peer preferences among adolescent deaf students. Sociometric ratings were obtained and analyzed for possible preferences. A marked peer preference for female students by both male and female students was found. In examining racial preferences, I found that white students rated same-race students higher than they rated minority students. Based on the data and analyses, the investigator found race to be secondary to sex in peer preferences among deaf adolescents. These findings are consistent with the sociometric literature on hearing adolescents.
Hormonal Control of Plasma Renin Substrate (Angiotensinogen)

SUMMARY The effect of ethinyl estradiol (EE2) and dexamethasone (Dex) upon plasma renin substrate (PRS) was studied in rats in relation to sexual maturation and pituitary function. Normal adult rats had large increases in PRS when given either EE2 or Dex. Prepubescent (25-day-old) rats also had a substantial increase in PRS following Dex, but no increase in PRS after EE2. In adult rats, hypophysectomy prevented the rise in PRS due to EE2 but did not prevent the increase in PRS due to Dex. Hepatic estrogen and glucocorticoid receptors were measured in immature and adult rats. Immature rats had markedly reduced concentration of hepatic estrogen receptors (16%), compared with adults. In contrast, glucocorticoid receptor concentration was not significantly different between immature and adult rats. The results indicate that the effect of estrogens and glucocorticoids upon PRS are mediated by pathways that are separable at the hormone receptor level.
Code Analysis for Software and System Security Using Open Source Tools

ABSTRACT Software security helps in identifying and managing risks. One of the effective ways to identify software vulnerabilities is to analyze its code. Code analysis (Chess & West, 2007) helps in catching common coding mistakes such as buffer overflow, unused variables, memory leaks, and various race conditions, which in turn optimizes computer programs, both in storage and computation aspects. Software developers use either open source tools or commercial tools for verification and validation of software. Without proper validation of a software/system using some standard guidelines, potential attackers can find ways to exploit vulnerabilities and bugs and then can gain control over a system, if they are successful. In this paper, we discuss some of the open source static code analysis and dynamic analysis tools, their merits, and limitations with respect to some target codes that contain possible threats. We consider C/C++ and Java programming languages for our experiments. For static code analyzers, we consider Flawfinder, Splint, and Cppcheck; PMD, Findbugs, and Valgrind for dynamic code analysis, and its plug-in, Memcheck, to perform dynamic analysis on executables. We provide our observations in a comparison table, highlighting these tools strengths and weaknesses.
Anomaly Identification Based on Flow Analysis

Recently, the concern about network management and network security has inspired many research topics, among which, research on detecting and identifying anomalies has attracted a lot of interest. In this paper, we propose an anomaly identification method based on traffic flow analysis. The result of the research proves that by assembling some features of traffic flows and calculating some specific extended metrics, we can successfully detect and identify network anomalies with high accuracy. Besides, the method also proves its efficiency with the ability to quantify network anomalies and locate relevant network nodes. The research validity has been verified by both simulation data and real network data
Compact units in proteins.

An explicit measure of geometric compactness called the coefficient of compactness is introduced. This single value figure of merit identifies those continuous segments of the polypeptide chain having the smallest solvent-accessible surface area for their volume. These segments are the most compact units of the protein, and the larger ones correspond to conventional protein domains. To demonstrate the plausibility of this approach as a method of identifying protein domains, the measure is applied to lysozyme and ribonuclease to discover their constituent compact units. These units are then compared with domains, subdomains, and modules found by other methods. To show the sensitivity of the method, the measure is used to successfully differentiate between native and deliberately misfolded proteins [Novotný, J., Bruccoleri, R. , & Karplus, M. (1984) J. Mol. Biol. 177, 787-818]. Methods that utilize only backbone atoms to define domains cannot distinguish between authentic and misfolded molecules because their backbone conformations are virtually superimposable. Compact units identified by this method exhibit a hierarchic organization. Such an organization suggests possible folding pathways that can be tested experimentally.
A New Technique for Vital Microscopic Studies of the Capillary Bed in Rat Skin

The use of reflected light offers an opportunity to study the microcirculation in peripheral tissue with a minimum of trauma. Ditzel5 and Bloch6 investigated the microcirculation in the human conjunctival vascular bed. Taylor and Lehrfeld7 watched the microcirculation in rat skin by means of a dissecting binocular microscope, and the same technique was adapted to human skin by Converse and Rapaport.8 The limitations in magnification in these studies are due to the relatively small amounts of reflected light passing through the optical system. The ability of amplifying light, contrast and image size by electronic image processing was utilized by Brown and Warned and Harders10 in studies of dimly illuminated circulatory beds in the human retina and con-
Joint fairness and sum rate resource allocation for NOMA communications

In this paper, we study fairness and sum rate performance issues in uplink non-orthogonal multiple access (NOMA) communication system by allocation of subbands and power to users. In a NOMA system, each subband can be shared by L users simultaneously, which leads to higher spectral efficiency than the Orthogonal Multiple Access (OMA) system. It has been studied that, without proper allocation of target data rate for each uplink NOMA user, a user can always be in outage. In this work, we constrain the number of subbands Ns that each user could use to prevent starvation of poor users. We have also analyzed the sum rate performance with different combination of L and Ns in the system. An algorithm to allocate the subbands and power to users is developed to maximize sum rate with proper fairness. The work tries to find the optimal combination of L and Ns to achieve the maximum sum rate for given K users in the system. The system performance of sum rate, fairness, and BER are simulated. The fairness of the proposed scheme is compared with prior NOMA algorithms. Though simple, the proposed fixed Ns scheme improves the fairness significantly.
Use of multiple data streams to conduct Bayesian biologic surveillance.

INTRODUCTION Emergency department (ED) records and over-the-counter (OTC) sales data are two of the most commonly used sources of data for syndromic surveillance. The majority of detection algorithms monitor these data sources separately and either do not combine them or combine them in an ad hoc fashion. This report outlines a new causal model that combines the two data sources coherently to perform outbreak detection. OBJECTIVES This report describes the extension of the Population-wide Anomaly Detection and Assessment (PANDA) Bayesian biologic surveillance algorithm to combine information from multiple data streams. It also outlines the assumptions and techniques used to make this approach scalable for real-time surveillance of a large population. METHODS A causal Bayesian network model used previously was extended to incorporate evidence from daily OTC sales data. At the level of individual persons, the actions that result in the purchase of OTC products and in admission to an ED were modeled. RESULTS Preliminary results indicate that this model has a tractable running time consisting of 209 seconds for initialization and approximately 4 seconds for every hour's worth of ED data, as measured on a Pentium-4 three-Gigahertz machine with two Gigabytes of RAM. CONCLUSION Preliminary results for surveillance using a new Bayesian algorithm that models the interaction between ED and OTC data are positive regarding the run time of the algorithm.
Advances in Brief A Single 3 . 7-Kilobase Messenger RNA Hybridizes to Immediate-Early Promoter-Enhancer of Human Cytomegalovirus in HL-60 and Acute Myeloid Leukemia Cells 1

Expression of a iiiKNA cross-hybridized to human cytomegalovirus immediate-early gene promoter-enhancer was detected in the human promyelocytic leukemia cell line HL-60. The 0.6 kilobase of NruI/Sacl DNA fragment of eukaryotic expression vector pCDIVIS representing human cytomegalovirus immediate-early gene promoter-enhancer was used as the probe to hybridize with polyadenylated RNA by the Northern blot analysis. A 3.7-kilobase strand of polyadenylated RNA was visual ized in the cytoplasmic fraction of HL-60 promyelocytes. In contrast, other human hematopoietic cell lines, hepatoma cells, and normal human fibroblasts did not show such a transcript by cross-hybridization. This transcript was called CMVE RNA. The expression of CMVE mRNA was also detectable in the fresh blast cells from patients with acute myeloid leukemia, and particularly from a patient with acute myeloid leukemia of the M3 type. Taken together, these findings suggest that the CMVE RNA-encoded gene plays an important role in the pathogenesis of acute promyelocytic leukemia.
Night life on the beach: selfing to avoid pollinator competition between two sympatric Silene species.

BACKGROUND AND AIMS Evolution of autonomous selfing may be advantageous because it allows for reproductive assurance. In co-flowering plants competing for pollinators, the least common and/or attractive could suffer pollen limitations. Silene niceensis and S. ramosissima are taxonomically related species sharing the same habitat, although S. ramosissima is less abundant and has a more restricted distribution. They also have the same a priori nocturnal pollinator syndrome, and show an overlapping flowering phenology. The aim of this study was to investigate whether a selfing strategy in S. ramosissima allows it to avoid pollinator competition and/or interspecific pollen transfer with S. niceensis, which would thus enable both species to reach high levels of fruit and seed set. METHODS The breeding system, petal colour, flower life span and degree of overlap between male and female phases, floral visitor abundance and visitation rates were analysed in two sympatric populations of S. niceensis and S. ramosissima in southern Spain. KEY RESULTS Autonomous selfing in S. ramosissima produced very high fruit and seed set, which was also similar to open-pollinated plants. Silene niceensis showed minimum levels of autonomous selfing, and pollen/ovule ratios were within the range expected for the breeding system. In contrast to S. niceensis, flower life span was much shorter in S. ramosissima, and male and female organs completely overlapped in space and time. Upper surface petals of both species showed differing brightness, chroma and hue. Flowers of S. niceensis were actively visited by moths, hawkmoths and syrphids, whereas those of S. ramosissima were almost never visited. CONCLUSIONS The findings show that different breeding strategies exist between the sympatric co-flowering S. niceensis and S. ramosissima, the former specializing in crepuscular-nocturnal pollination and the latter mainly based on autonomous selfing. These two strategies allow both species to share the restricted dune habitat in which they exist, with a high female reproductive success due to the absence of pollinator competition and/or interspecific pollen flow.
Comparative analysis of the localization of lipoteichoic acid in Streptococcus agalactiae and Streptococcus pyogenes

The cellular locations of deacylated lipoteichoic acid (dLTA) and lipoteichoic acid (LTA) were examined in late-exponential-phase cells of a serotype III strain of Streptococcus agalactiae (group B streptococci [GBS]) isolated from an infant with late-onset meningitis and compared with a fresh clinical isolate of Streptococcus pyogenes (group A streptococci [GAS]). LTA and dLTA were found to be associated with the protoplast membranes of both organisms, with only dLTA found in mutanolysin cell wall digests. Both organisms released dLTA during growth, but only the GAS released substantial levels of LTA into the culture medium. However, penicillin treatment (5 micrograms/ml for 60 min) of GBS resulted in the recovery of LTA in cell wall digests as well as in the culture medium. These results suggest that under normal growth conditions, the hydrophobic region (glycolipid) of LTA remains associated with the cytoplasmic membrane of GBS and unavailable for hydrophobic interactions at the cell surface with epithelial cells. In contrast, release of LTA into the environment by the GAS allows the fatty acid moieties to interact with hydrophobic domains on the surface of epithelial cells. These results may help explain the marked differences in the specificity of binding between these two major streptococcal pathogens for human fetal and adult epithelial cells.
Usability evaluation of academic record system at the International Islamic College (HC)

The Academic Management System (AMS) is a system capable of storing, managing, and modifying student related information within a database. The AMS is a necessary tool that assists university staff in handling students' big data within the institution. The lack of system usability within the AMS has led to low staff productivity, dissatisfaction, repetitive errors in data entry, emotional distraction which eventually leads to time wastage, substantial monetary loss, and causes demotivation among staff. Hence, this study aims to evaluate the usability of AMS at the International Islamic College (IIC) using the Usability Testing evaluation technique. This research is conducted using two data collection techniques which are the qualitative Usability Testing and the quantitative questionnaire survey. This study is important in order to discover any usability issues of the AMS and receive recommendations from the users' point of view as to improve the system. Besides that, this study also will disclose how learnable, memorable, efficient, error-free, ability to satisfy as well as to distinguish users' emotions towards the AMS.
Alloreactive natural killer cells in targeting high-risk leukaemias

Natural killer (NK) cells express surface receptors that regulate potent effector functions, such as cytolytic activity and release of cytokines, which play a central role in inflammatory response and immunoregulation. In this paper, major advances are outlined from the original discovery of HLA-class I-specific inhibitory receptors in humans to recent, particularly successful, clinical applications in the cure of high-risk, otherwise fatal leukaemias. The central role of donor-derived “alloreactive” NK cells in eradicating leukaemic cells in the T-cell-depleted haploidentical haematopoietic stem cell transplantation setting became evident. Since alloreactive NK cells seem to play a key role also in preventing graft rejection and graft-vs-host disease, they may be an ideal tool to treat high-risk leukaemias in the haematopoietic stem cell transplantation setting.