Miracle-dz/UniFAR-FTUs huggingface dataset:
Avoiding Degeneracies in Ordinal Unfolding Using Kemeny-Equivalent Dissimilarities for Two-Way Two-Mode Preference Rank Data

Abstract In this paper a simple but effective procedure to avoid degeneracies in ordinal Unfolding for preference rank data based on the Kemeny distance is proposed. Considering Unfolding as a particular MDS procedure with missing within-set proximities, unknown proximities are first estimated using correlations related to the Kemeny distance, and then the complete proximity matrix is analyzed in a standard MDS framework. A simulation study shows that our proposal is able to both recover the order of the preferences and reproduce the position of both rankings and objects in a geometrical space. Several applications on real data sets show that our procedure returns non-degenerate Unfolding solutions.
Roflumilast as a Potential Therapeutic Agent for Cecal Ligation and Puncture-Induced Septic Lung Injury

Abstract Purpose/Aims This study focused on delineating the possible effects of roflumilast (ROF), a selective phosphodiesterase 4 (PDE4) inhibitor, in rats with cecal ligation and puncture (CLP)-induced polymicrobial sepsis, and investigated whether ROF can act as a protective agent in sepsis-induced lung damage. Material and methods Four experimental groups were organized, each comprising eight rats: Control, Sepsis, Sepsis + ROF 0.5 mgkg−1, and Sepsis + ROF 1 mgkg−1 groups. A polymicrobial sepsis model was induced in the rats by cecal ligation and puncture under anesthesia. Twelve hours after sepsis induction, the lungs were obtained for biochemical, molecular, and histopathological analyses. Results In the sepsis group’s lungs, the TNF-α, IL-1β, and IL-6 mRNA expression levels peaked in the sepsis group’s lung tissues, and ROF significantly decreased these levels compared with the sepsis group dose-dependently. ROF also significantly decreased MDA levels in septic lungs and increased antioxidant parameters (SOD and GSH) compared with the sepsis group. Histopathological analysis results supported biochemical and molecular results. Conclusions ROF, a PDE4 inhibitor, suppressed the expression levels of pro-inflammatory cytokines, alleviated lung damage (probably by blocking neutrophil infiltration), and increased the capacity of the antioxidant system.
Epidemiology of Lumbar Degenerative Phenotypes of Children and Adolescents: A Large-Scale Imaging Study

Study Design: Cross-sectional study. Objective: Recently, there has been a rise in children and adolescents developing low back pain and/or sciatica. Degenerative lumbar spine MRI phenotypes can occur in this population but reports have been sporadic and the true incidence of such spine changes remains debatable. As such, the study aimed to address the epidemiology of MRI phenotypes of the lumbar spine in this young population. Methods: 597 children and adolescents with lumbar MRIs were included in the study. T1- and T2-weighted lumbar images from L1/2 to L5/S1 were analyzed in axial and sagittal planes. Global phenotype assessment was performed of each level and based on established nomenclature protocols. Results: The cohort consisted of 57.3% (342) boys and 42.7% (255) girls, with a mean age of 10.75 ± 5.25 years (range: 0 to 18 years). The prevalence of imaging findings of lumbar disc degeneration (LDD) and lumbar disc herniation (LDH) were 2.2% (95% CI: 0.93–3.43) and 5.8% (95%CI: 2.58-8.99), respectively. There was significant difference between each disc segment from L1/2 to L5/S1 for both LDD and LDH. Schmorl’s nodes were noted in 16 cases (2.7%, youngest case as 15 years), with 11 boys (68.8%) and most frequent segment as L3/4. Modic changes and high-intensity zones were absent in this cohort. Conclusions: LDD can emerge as early as the first decade of life with Schmorl’s nodes, without additional specific phenotypes, including Modic changes and high-intensity zones. The study provides valuable information of a unique age group that is often under-represented but equally important as adults.
Modeling Of Unsteady Heat Transfer By Impact Between Gas Particles And A Cold Wall In A Spherical Combustion Vessel

To evaluate the wall heat losses in combustion vessel, an alternative to existing macroscopic models of heat transfer is suggested. This study aims to provide a physical approach for wall heat transfer based on kinetic theory of gases to describe the conduction phenomena between gas particles and the cold wall in short scales. The model mentioned is implemented in a code simulating combustion in a constant volume spherical chamber.
Efficacy and safety of bioresorbable scaffolds in patients with coronary bifurcation lesions: A systematic review and meta-analysis

Background Bioresorbable scaffolds (BRS) were considered to be beneficial for coronary bifurcation lesions regarding the avoidance of lateral branch opening incarceration after complete absorption. However, data is limited in this setting. The aim of this meta-analysis was to evaluate the short (6-month) and medium-term (1-year) outcomes of BRS in patients with coronary bifurcation lesions. Methods PubMed, EMBASE, Web of Science, Cochrane library databases were searched to find the studies of BRS implantation in patients with coronary bifurcation lesions. The effective outcome was target lesion revascularization. The safety outcomes included major adverse cardiovascular events, target vessel revascularization, myocardial infarction, definite or probable scaffold thrombosis, and cardiac death. Results A total of 1204 patients involved in 12 studies were included. The pooled estimate rate of target lesion revascularization as efficacy outcome was highly consistent between 6-month and 1-year follow-up, which was 4.74% (95% CI 2.36–9.54%, I2 = 41.5%, p = 0.14) and 4.37% (95% CI 3.05–5.69%, I2 = 4.6%, p = 0.39). The pooled estimated rate of major adverse cardiovascular events as safety outcome was 5.50% and 7.31% for both 6-month and 1-year follow-up. The pooled estimated rate of target vessel revascularization, myocardial infarction, definite or probable scaffold thrombosis, and cardiac death at 1-year follow-up was 5.92%, 2.52%, 1.69%, and 0.42%. Conclusions The application of BRS for coronary bifurcation lesions is acceptable in efficacy outcome, but the high rate of scaffold thrombosis remains of concern (Registered by PROSPERO, CRD42019140341).
Anti-Angiogenic Effect of Cantharellus cibarius Extracts, its Correlation with Lipoxygenase Inhibition, and Role of the Bioactives Therein

Abstract Angiogenesis is a complex physiological process that cannot be treated with single agent therapy. Several edible fungi have been known to encompass bioactive compounds, and are promising sources of multi-component drugs. One such widely consumed edible fungi is Cantharellus cibarius, which has been explored for its biological activities. The present study focused on assessing the anti-angiogenic activity of petroleum ether and ethanol extracts of C. cibarius using chick chorioallantoic membrane (CAM) assay. Both the extracts showed a dose-dependent response which was compared with the anti-angiogenic activity of the positive controls silibinin, and lenalidomide. The extracts were also studied for their lipoxygenase (LOX) inhibitory potential and compared to ascorbic acid as the positive control. The IC50 values of the petroleum ether extract, ethanol extract, and ascorbic acid for LOX inhibition assay were 135.4, 113.1, and 41.5 µg/mL, respectively. Although both the extracts showed similar responses in CAM assay, ethanol extract proved to be more potent in LOX inhibition assay. Finally, the extracts were investigated for their chemical composition using GC-MS. A correlation between LOX inhibition and anti-angiogenic potential was established at the molecular level. A meticulous literature search was carried out to correlate the biochemical composition of the extracts to their anti-angiogenic activity.
Mechanism of Cdk5-synaptophysin-SNARE pathway in acute and chronic inflammatory pain.

PURPOSE Currently, there is no favorable treatment plan for inflammatory pain, so exploring new analgesics is still a research hotspot in this area. Cyclin-dependent protein kinase 5 (Cdk5) is a pain-related protein kinase, but its mechanism in inflammatory pain has not been clarified. This research aimed to explore the mechanism of Cdk5-synaptophysin (Syn)-soluble N-ethylmaleimide-sensitivity factor (NSF) attachment protein receptor (SNARE) in acute and chronic inflammatory pain. METHODS Rat models of acute and chronic inflammatory pain were induced by formalin and complete Freund's adjuvant (CFA), separately, and some rats injected with normal saline through intraplantar injection were divided into a control group. Thirty minutes before modeling, rats were given Cdk5 inhibitor (Roscovitine, Ros), SNARE scavenger (botulinum toxin A, BTTA), glutamate receptor inhibitor (MK801), and dimethyl sulfoxide (DMSO) through spinal canals, and the paw withdrawal threshold (PWT) and thermal withdrawal latency (PWL) at difference time points were compared. RESULTS Compared with rats in the control group, those in the rat models of acute and chronic inflammatory pain showed lower PWT and PWL, higher Cdk5 enzyme level, tight correlation of Cdk5 with Syn, SNARE, p25 proteins, and higher levels of Cdk5, Syn and SNARE. And the above situation was dramatically reversed under intervention of Ros, BTTA and MK801. CONCLUSION Cdk5-Syn-SNARE pathway is a therapeutic target for inflammatory pain. Blocking the activation of this pathway is beneficial to exert analgesic effect.
Inkjet Printing Transparent and Conductive MXene (Ti3C2Tx) Films: A Strategy for Flexible Energy Storage Devices.

MXene is a generic name for a large family of two-dimensional transition metal carbides or nitrides, which show great promise in the field of transparent supercapacitors. However, the manufacturing of supercapacitor electrodes with a high charge storage capacity and desirable transmittance is a challenging task. Herein, a low-cost, large-scale, and rapid preparation of flexible and transparent MXene films via inkjet printing is reported. The MXene films realized the sheet resistance (Rs) of 1.66 ± 0.16 MΩ sq-1 to 1.47 ± 0.1 kΩ sq-1 at the transmissivity of 87-24% (λ = 550 nm), respectively, corresponding to the figure of merit (the ratio of electronic to optical conductivity, σDC/σOP) of ∼0.0012 to 0.13. Furthermore, the potential of inkjet-printed transparent MXene films in transparent supercapacitors was assessed by electrochemical characterization. The MXene film, with a transmittance of 24%, exhibited a superior areal capacitance of 887.5 μF cm-2 and retained 85% of the initial capacitance after 10,000 charge/discharge cycles at the scan rate of 10 mV s-1. Interestingly, the areal capacitance (192 μF cm-2) of an assembled symmetric MXene transparent supercapacitor, with a high transmittance of 73%, still surpasses the performance of previously reported graphene and single-walled carbon nanotube (SWCNT)-based transparent electrodes. The convenient manufacturing and superior electrochemical performance of inkjet-printed flexible and transparent MXene films widen the application horizon of this strategy for flexible energy storage devices.
Reasons for refusing referrals and challenges to effectual engagement in tele-treatment for depression among low-income homebound older adults

Abstract Objectives: To describe reasons for refusal to be referred to or enroll in a depression treatment study and post-enrollment challenges to treatment engagement and technology-related problems among low-income homebound individuals aged 50+ years with depression. Methods: Data came from a 3-arm randomized clinical trial that evaluated real-world effectiveness of lay counselor-delivered behavioral activation (BA) versus clinician-delivered problem-solving therapy (PST). Interventionists were embedded in a large home-delivered meals program and treatment sessions were videoconferenced; hence Tele-BA and Tele-PST. We described refusal reasons of those who refused initial case manager referrals (n = 279), telephone screening (n = 64), enrollment (n = 47), or post-enrollment baseline assessments (n = 18). We used inductive thematic analysis to explore challenges to effectual treatment engagement and tele-delivery-related problems among Tele-PST or Tele-BA participants (n = 183) from the interventionists’ tele-session process recordings. Results: More than a third of potentially eligible older adults refused their case managers’ referral, and a quarter of those who accepted referral refused further screening or enrollment. Three quarters of those who refused reported no interest or need or declined to talk about depression. Others refused given their busy schedule with medical appointments and caregiving. Nearly 80% of Tele-BA or Tele-PST participants had some challenges to effectual engagement in treatment sessions due to environmental and health-related conditions and other life stressors including financial distress. Though many tele-sessions had connectivity and other technology-related problems, these did not affect depression outcomes. Conclusion: Mental health service providers for low-income older adults need to be aware of these challenges when adopting best practice strategies for them.
Medical Financial Hardship in Survivors of Adolescent and Young Adult Cancer in the United States.

BACKGROUND Cancer and its treatment can result in lifelong medical financial hardship, which we aimed to describe among adult survivors of adolescent and young adult (AYA) cancers in the United States. METHODS We identified adult (aged ≥18 years) survivors of AYA cancers (diagnosed ages 15-39 years) and adults without a cancer history from the 2010-2018 National Health Interview Surveys. Proportions of respondents reporting measures in different hardship domains (material [eg, problems paying bills], psychological [eg, distress], and behavioral [eg, forgoing care due to cost]) were compared between groups using multivariable logistic regression models and hardship intensity (cooccurrence of hardship domains) using ordinal logistic regression. Cost-related changes in prescription medication use were assessed separately. RESULTS A total of 2588 AYA cancer survivors (median = 31 [interquartile range = 26-35] years at diagnosis; 75.0% more than 6 years and 50.0% more than 16 years since diagnosis) and 256 964 adults without a cancer history were identified. Survivors were more likely to report at least 1 hardship measure in material (36.7% vs 27.7%, P < .001) and behavioral (28.4% vs 21.2%, P < .001) domains, hardship in all 3 domains (13.1% vs 8.7%, P < .001), and at least 1 cost-related prescription medication nonadherence (13.7% vs 10.3%, P = .001) behavior. CONCLUSIONS Adult survivors of AYA cancers are more likely to experience medical financial hardship across multiple domains compared with adults without a cancer history. Health-care providers must recognize this inequity and its impact on survivors' health, and multifaceted interventions are necessary to address underlying causes.
A Tailored Approach

Two major pathophysiologic factors contribute to elevated levels of portal pressure in patients with cirrhosis: increased intrahepatic (sinusoidal) vascular resistance and increased portal blood inflow. Over the natural course of advanced chronic liver disease (ACLD), portal pressure rises, eventually surpassing the threshold of 10 mmHg or greater that defines clinically significant portal hypertension (CSPH). 1 In the setting of CSPH, progressive peripheral and splanchnic vasodilation ultimately lead to increases in both heart rate and cardiac output, defining the hyperdynamic circulatory portal-hypertensive syndrome. 2 Endoscopic screening for gastroesophageal varices
Barriers to Care Experienced by Patients Who Inject Drugs During the COVID-19 Pandemic: A Qualitative Analysis

Objectives: To identify the barriers to accessing health care and social services faced by people who inject drugs (PWID) during the coronavirus disease 2019 (COVID-19) pandemic. Methods: This report is a sub-analysis of a larger qualitative study. Semi-structured interviews were conducted with PWID admitted to an academic medical center from 2017 to 2020 for an invasive injection-related infection. Standard qualitative analysis techniques, consisting of both inductive and deductive approaches, were used to identify and characterize the effects of COVID-19 on participants. Results: Among the 30 PWID interview participants, 14 reported barriers to accessing health and addiction services due to COVID-19. As facilities decreased appointment availability or transitioned to telemedicine, PWID reported being unable to access services. Social distancing led to isolation or loneliness during hospital stays and in the community. Recovery meetings and support groups, critical to addiction recovery, were particularly affected. Other participants reported that uncertainty and fear of contracting the virus generated changes in behavior that led them to avoid seeking services. Conclusions: COVID-19 has disrupted health systems and social services, leading PWID to experience unprecedented barriers to accessing and maintaining health and addiction services in both inpatient and outpatient settings. Opioid use disorder management must be understood as a holistic process, and a multidisciplinary approach to ensuring comprehensive care, even in the midst of this pandemic, is needed.
Perceptual Difficulty Persistently Increases Dominance in Binocular Rivalry—Even Without a Task

A major objective of perception is the reduction of uncertainty about the outside world. Eye-movement research has demonstrated that attention and oculomotor control can subserve the function of decreasing uncertainty in vision. Here, we ask whether a similar effect exists for awareness in binocular rivalry, when two distinct stimuli presented to the two eyes compete for awareness. We tested whether this competition can be biased by uncertainty about the stimuli and their relevance for a perceptual task. Specifically, we have stimuli that are perceptually difficult (i.e., carry high perceptual uncertainty) compete with stimuli that are perceptually easy (low perceptual uncertainty). Using a no-report paradigm and reading the dominant stimulus continuously from the observers’ eye movements, we find that the perceptually difficult stimulus becomes more dominant than the easy stimulus. This difference is enhanced by the stimuli’s relevance for the task. In trials with task, the difference in dominance emerges quickly, peaks before the response, and then persists throughout the trial (further 10 s). However, the difference is already present in blocks before task instruction and still observable when the stimuli have ceased to be task relevant. This shows that perceptual uncertainty persistently increases perceptual dominance, and this is magnified by task relevance.
Evolution of the Unfolded Protein Response in Plants.

The Unfolded Protein Response (UPR) in plants is elicited by endoplasmic reticulum stress which can be brought about by adverse environmental conditions. The response is mediated by a conserved signaling network composed of two branches - one branch involving INOSITOL REQUIRING ENZYME1- BASIC LEUCINE ZIPPER60 (IRE1-bZIP60) signaling pathway and another branch involving the membrane transcription factors, bZIP17 and - 28. The UPR has been reported in Chlamydomonas reinhardtii, a unicellular green alga, which lacks some canonical UPR signaling components found in vascular plants, raising the question whether C. reinhardtii uses other means such as oxidative signaling or Regulated IRE1-Dependent Decay to activate the UPR. In vascular plants IRE1 splices bZIP60 mRNA in response to endoplasmic reticulum stress by cutting at a site in the RNA that is highly conserved in structure and sequence. Monocots have a single IRE1 gene required for viability in rice, while dicots have two IRE1 genes, IRE1a and -b. Brassicas have a third IRE1 gene, IRE1c, which lacks a lumenal domain, but is required in combination with IRE1b for gametogenesis. Vascular and non-vascular plants upregulate a similar set of genes in response to endoplasmic reticulum stress despite differences in the complexity of their UPR signaling networks. This article is protected by copyright. All rights reserved.
Light scattering pattern specific convolutional network static cytometry for label‐free classification of cervical cells

Cervical cancer is a major gynecological malignant tumor that threatens women's health. Current cytological methods have certain limitations for cervical cancer early screening. Light scattering patterns can reflect small differences in the internal structure of cells. In this study, we develop a light scattering pattern specific convolutional network (LSPS‐net) based on deep learning algorithm and integrate it into a 2D light scattering static cytometry for automatic, label‐free analysis of single cervical cells. An accuracy rate of 95.46% for the classification of normal cervical cells and cancerous ones (mixed C‐33A and CaSki cells) is obtained. When applied for the subtyping of label‐free cervical cell lines, we obtain an accuracy rate of 93.31% with our LSPS‐net cytometric technique. Furthermore, the three‐way classification of the above different types of cells has an overall accuracy rate of 90.90%, and comparisons with other feature descriptors and classification algorithms show the superiority of deep learning for automatic feature extraction. The LSPS‐net static cytometry may potentially be used for cervical cancer early screening, which is rapid, automatic and label‐free.
Seed Predation of Interseeded Cover Crops and Resulting Impacts on Ground Beetles

Abstract Interseeding cover crops into standing grains can promote both agronomic and environmental benefits within agroecosystems. Producers must decide which cover crops are the best fit for their goals, and whether diverse cover crop mixtures provide benefits that are worth the increased seed cost. Broadcast seeding is an accessible strategy to try interseeding but can lead to patchy establishment; it is unknown how much seed loss is due to seed predators. In a two-year study, six cover crop species—planted as either single species or mixtures—were interseeded into standing corn. We evaluated seed predation at the time of seeding, agronomic impact through cover crop, and weedy biomass at the end of the season, and conservation impact through activity-density of ground beetles (Coleoptera: Carabidae). Cover crop seeds were vulnerable to seed predation, primarily by vertebrate seed predators, and seed loss varied across cover crop species. Cover crop biomass did not differ according to cover crop diversity and weedy biomass was not affected by cover crop presence or species. Cover crop diversity effects on carabid activity-density were inconsistent: carabids were higher in diverse mixtures in 1 year of the study, but only predicted by vegetative cover, not by cover crop, in the second year. Interseeding cover crops into corn has potential benefits for ground beetles, although the value of mixtures must be further explored.