Miracle-dz/UniFAR-FTUs huggingface dataset:
Total Synthesis of Korormicin

Recently, we have assigned the (5S,3′R,9′S,10′R) stereochemistry to planar korormicin (1) on the basis of the specific rotations of the four possible diastereoisomers [i.e., (5S,3′R,9′S,10′R), (5S,3′S,9′S,10′R), (5S,3′S,9′R,10′S), and (5S,3′R,9′R,10′S) isomers], which were prepared by a total synthesis. In this article, we describe the synthetic aspects in detail. The intermediates in the synthesis are enamino lactone (5S)-4 and both enantiomers of acid 5 and of boronate ester 7. Lactone (5S)-4 and boronate 7 with (9′S,10′R) and (9′R,10′S) chiralities were prepared through asymmetric dihydroxylation of olefins 11 and 30, respectively, with AD-mix-α or -β. Compounds (3′R)- and (3′S)-5 were prepared by kinetic resolution of rac-19 with asymmetric epoxidation. Condensation of (5S)-4 and (3′R)- or (3′S)-5 with DCC in the presence of DMAP and PPTS furnished the advanced intermediate 6 with (5S,3′R) and (5S,3′S) chiralities in good yields. Addition of PPTS was important to prevent formation of acyl urea 24. A nickel-catalyzed coupling reaction between 6 and 8 [prepared in situ from (9′S,10′R)- or (9′R,10′S)-7 and MeLi] produced 9, which upon deprotection with Bu4NF furnished the four diastereoisomers of korormicin (1).
Effectiveness of the Inclusion of Teachers with Disabilities in the Teaching and Learning Situation in Bulawayo Metropolitan Province Schools

The study sought to establish the effectiveness of the inclusion of teachers with physical disabilities in the teaching and learning situation in Bulawayo Metropolitan province schools. It was guided by the theoretical framework of Bronfenbrenner’s social ecological systems theory. The mixed methods approach with case study were used to enable an in-depth exploration of purposively snowballed Bulawayo Metropolitan province schools. Questionnaire and interview were employed for generating interim and thematic analyzed data. This study revealed that teachers with disabilities were given minimal opportunities by schools thereby affecting their inclusion and effective curriculum implementation. Negative attitude, limited teaching aids, lack of funds and discrimination, stereotyping and stigmatization were some of the main challenges diluted the effectiveness of the inclusion ofteachers with disabilities in the teaching and learning situation in schools.The study recommended that there is need for the Ministry of Primary and Secondary Education to revise and review the education policy on the inclusion of teachers with disabilities in the teaching and learning and provide clear guidelines on how to accommodate them. It is recommended that there is need to cultivate and nurture positive attitudes towards the inclusion of teachers with disabilities to stakeholders such as school Heads, teachers without physical disabilities, students and parents in order to achieve the effective inclusion of teachers with disabilities in Zimbabwean schools. There is need for the teachers with disabilities to be given due recognition and equal rights in accessing all school facilities to achieve their effective inclusion in the teaching and learning situation.
of the Peptidoglycan-Associated Proteins b and c of Escherichia coli K 12

To collect information on synthesis and regulation of the peptidoglycan-associated pore-forming outer membrane proteins b and c, mutants resistant to phages Mel and TuIa were analyzed. Genetic analysis showed three linkage groups, corresponding with the genes tolF (phenotype b-c+), meoA (phenotype b+c -) and ompB (phenotypes b c , b c +, b++c and b++c~). It has recently been described that also a b+c phenotype can occur in the latter linkage group [Chai, T. , Foulds, J., J. Bacteriol. 130, 781 786 (1977)]. Among ompB (b-c+)/meoA (b+c -) double mutants strains were found with the b+c phenotype, showing that ompB is not the structural gene for protein b. Studies on purified proteins b and c showed profound differences between the two proteins with respect to the electrophoretic mobility of fragments obtained by treatment with cyanogen bromide, trypsin and chymotrypsin. The amino acid in position three of the amino-termini of proteins b and c, isolated from isogenic strains, were identified as isoleucine and valine respectively. Both the genetic and biochemical results are consistent with a model recently published [Ichihara, S. , Mizushima, S. , J. Biochem. (Japan) 83, 1095-1100 (1978)] which predicts that tolF and meoA are the structural genes for the proteins b and c respectively and that ompB is a regulatory gene whose product regulates the levels of both proteins.
TESTING OF A DASH 8 Q400 IN THE NASA AMES 80x120' WIND TUNNEL

In 2000 a need arose to test a full scale Dash 8 Q400 turboprop aircraft in the 80x120 foot wind tunnel, at the NASA Ames National FullScale Aerodynamics Complex (NFAC). The main purpose was to simulate aircraft ground operations in very strong winds, and record propeller blade strains in these conditions, for certification purposes. This task involved lifting a complete airworthy flight test aircraft into the wind tunnel, where the Main Landing Gear (MLG) was secured onto steel pads at the wind tunnel floor level. Loads applied to the MLG were carefully considered. The total aerodynamic sideload in a 90-degree crosswind of 65 knots was estimated to be over 17,000 lbf. Aircraft yawing moments were restrained by differential X loads (fore & aft) on the MLG. The effects of engine and propeller thrust were also considered. Force & moment data from the balance were monitored during the testing, and were compared to the pre-test estimates. An onboard crew of two Test Pilots and one Flight Test Engineer, from the Bombardier Flight Test Center (BFTC) in Wichita, operated the aircraft in the tunnel, with either the left or the right engine running. Wind-on testing was done on three consecutive night shifts, with no significant problems. A total of 124 data points were taken, at three yaw angles (beta) of 142, 225 and 270 degrees, in windspeeds up to 65 kts (75 mph or 120 km/hr). After the testing, the aircraft was quickly returned to airworthy condition, and flew back to BFTC on the day after the lift-out from the wind tunnel. The test was successful in obtaining precise propeller blade strain data, in accurately controlled strong wind conditions, and in the presence of completely realistic airframe influences. Although the 80x120' tunnel was designed to accommodate full scale aircraft, the Q400 with a span of over 93 feet and length of over 107 feet, was certainly the largest aircraft yet tested in this facility, or in any other wind tunnel. The main purpose of this paper is to present some information on forces and moments experienced by the Q400 in a 90-degree crosswind, including the effects of various power settings on the downwind propeller. TESTING OF A DASH 8 Q400 IN THE NASA AMES 80X120' WIND TUNNEL
The efficacy of intralesional injection of autologous platelet rich plasma versus normal saline dressing in chronic non-healing ulcers

Background: Platelet-rich plasma (PRP) can potentially enhance healing of chronic non-healing ulcer by increasing the delivery of various growth factors from the α-granules contained in platelets. Aim of this prospective randomized study was to evaluate the efficacy of autologous PRP versus normal saline (NS) at chronic non healing ulcer in relation to wound healing on the basis of ulcer size reduction, duration of healing, complete or partial healing and side effectsMethods: Fifty four patients with chronic non-healing ulcer were randomly divided into two equal groups: PRP group (treated with PRP) and NS group. Observations were made regarding pain, slough, discharge, granulation, reduction in ulcer size and volume on every 7th day till 4 weeks.Results: Reduction in area and volume of ulcers at the end of treatment was 12.27±4.10 cm2 and 6.88±5.26 cm3 in PRP group and 9.25±1.89 cm2 and 4.25 ±1.05 cm3 in NS group. In PRP group 59.25% had no discharge, 74.08% had no slough, 62.97% had no pain while in NS group no patient was without discharge, 14.81% patient had no slough, 74.07% had minimal pain on 28th day. In PRP group 22.22% ulcers were completely healed while in NS groups all ulcers were partially healed.Conclusions: PRP is more effective than NS on chronic non-healing ulcers as it causes more rapid healing, rapid relief from pain and early decrease in discharge and slough in all age groups and sex; irrespective of type, size, site, duration and etiology of ulcer.
Phenolic contents and antimicrobial activity of some kinds of Libyan honey

The phenolic contents of 6 Libyan honey varieties of different floral sources were determined. Honey samples included the 5 mono-floral kinds of honey, Ziziphus louts, Citrus medica, Thymus capitatus,Amygdaluscommunis and Commiphormyrrha, while the multi-floral honey was Rabia (spring) honey. The analysis of phenolic compounds was performed using High Pressure Liquid Chromatography (HPLC). Twenty three phenolic components in the differentkinds of honey were determined. The highest number of phenolic components were found in the darker honey, Thymus and Commiphor followed by Citrus, Rabia and Ziziphus, respectively. The least number of phenolic components were detected in Amygdalus (only 4). p-Hydroxybenzoic acid was found in all studied honey varieties, while rutin was not detected in any of the honey samples analyzed. Gallic acid and chrysin were found only in Thymus honey, Caffeic acid, salicylic acid and pinostrobin were only in Commiphor honey, while catechin, daidzein and pyrogallic were detected only in Citrus honey. The antimicrobial effect on Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Enterococcus faecalis, Pseudomonas aeuroginosa, Escherichia coli, Bacteriods spp. , Sarcina spp. and Candida albicanswas studied. All honey samples inhibited the growth of Escherichia coli with different degrees, where P<0.001. Among all bacteria, Bacteroids spp. and Klebsiella pneumoniae were the most resistant against most honey samples.
FINDING GROUPS OF CONSUMERS WITH SIMILAR PREFERENCE WEIGHTS USING CLUSTERWISE LINEAR REGRESSION

In this paper an extension of the Clusterwise Linear Regression method is proposed, a FORTRAN computer program for the application to preference data was developed. The method solves the problem of finding a given number of clusters of subjects that attribute the same importance to perceived product dimensions in the formation of product preference. It is particularly useful when consumers' evoked sets of products are small and multicollinearity plays a role in fitting preference models at the individual level. An application to data on elderly people's preferences for meat products is given. 137
Fast Screening of Single-Nucleotide Polymorphisms Using Chip-Based Temperature Gradient Capillary Electrophoresis

Abstract Recently, the analysis of single-nucleotide polymorphisms (SNPs) has attracted much attention. Although many techniques have been reported, new methods with high resolving power, low-cost, and fast speed are still required to meet the great demand of analyzing and detecting large amount of SNPs in the human genome. Capillary electrophoresis (CE) in the microchip format is a powerful separation technique, and has been applied to many fields in recent years, including SNPs detection. In this work, we present a fast SNPs detection scheme based on chip-based temperature gradient capillary electrophoresis. The cross-channel CE chip is made of poly- (dimethylsiloxane) (PDMS). A temporal temperature gradient with a precision of 0.1°C per step was applied on the chip during the separation process. The Cy5-labeled PCR products which contain one and two SNP sites were separated and detected. The homoduplexes and heteroduplexes were successfully base-line resolved and the total time of a single run was only 8 min. The separation was also confirmed by DHPLC. This work indicates that chip-based temperature gradient capillary electrophoresis is a fast and convenient screening approach for recognizing the presence of SNPs prior to further characterization. This method can be used for detecting both known and unknown mutations.
Visible transmission spectroscopy for the assessment of egg freshness

The objective of this research was to investigate the feasibility of visible transmission spectroscopy for the non-destructive assessment of the freshness of an individual egg. A total of 600 intact white-shelled eggs of the same flock (Lohmann, 40 weeks of age) were measured. To obtain a considerable variation in freshness, groups consisting of 60 eggs were stored (18 °C, 55% RH) for 0, 2, 4, 6, 8, 10, 12, 14, 16 and 18 days. The non-destructive spectral measurements were compared with the two most widely used destructive freshness parameters, namely Haugh units and albumen pH. A partial least squares (PLS1) model was built in order to predict Haugh units and pH of the albumen based on the transmission spectra. The correlation coefficients between the predicted value and the measured value were 0.842 and 0.867 for Haugh unit and pH of the albumen, respectively. These results show that the light transmission spectrum of an egg provides quantitative information about egg freshness. Relevant information concerning egg freshness is restricted to the interval between 570 and 750 nm. Furthermore, the models obtained for both destructive parameters were strikingly similar, indicating that Haugh unit and pH have the same physico-chemical background. Copyright © 2006 Society of Chemical Industry
Feasibility Analysis and New Venture Performance in Rivers State, Nigeria

This study examined the influence of feasibility analysis on new venture performance in Rivers State, Nigeria. The study adopted a descriptive research design, and collected data via a cross-sectional survey, using questionnaire as the instrument of inquiry. The population of the study comprised twenty five (25) new ventures that have been in operation for one to five (1-5) years. A sample of fifty (50) top management personnel was obtained from the study population on a sample frame of two (2) respondents per firm. The test units were arrived at, using the purposive sampling technique. The final analysis of the study was however, based on forty-seven (47) properly filled and returned questionnaire. Regression analysis was used as the test statistic; relying on the Statistical Package for Social Sciences (SPSS) version 22.0. The study found that feasibility analysis boosts new venture performance through sustained patronage, new venture survival and new venture growth. Feasibility analysis is thus a key factor in the achievement of new ventures performance. The study therefore, concludes that feasibility analysis influences new venture performance and that new venture performance rests of thorough feasibility analysis; and recommends that entrepreneurs should ensure that appropriate feasibility analysis is done before launching new ventures.
Characterization of a Packaged Triboelectric Harvester Under Simulated Gait Loading for Total Knee Replacement

Load sensing total knee replacement (TKR) implants are useful tools for monitoring prosthesis health and providing quantitative data to support patient claims of pain or instability. However, powering such devices throughout the entire life of the knee replacement is a challenge, and self-powered telemetry <italic>via</italic> energy harvesting is an attractive solution. In this article, we implemented vertical contact mode triboelectric energy harvesters inside a knee implant package to generate the power required for embedded digitization and communications circuitry. The harvesters produce small-scale electric power from physiologically relevant loads transmitted through the knee. Experiments were performed on a joint motion simulator with an instrumented package prototype between the polyethylene bearing and tibial tray. The amplitude and the pattern of the power output varied with the input loadings. Under sinusoidal loading the maximum apparent power harvested was around 7 <inline-formula><tex-math notation="LaTeX">$\mu$</tex-math></inline-formula>W at (50–2000)N whereas, under vertical compressive gait loading the harvesters generated around 10 <inline-formula><tex-math notation="LaTeX">$\mu$</tex-math></inline-formula>W at average human knee loads of (151–1950)N and 20 <inline-formula><tex-math notation="LaTeX">$\mu$</tex-math></inline-formula>W when the maximum applied load was increased by 25%. Full six degrees-of-freedom gait load/motions at 0.67 Hz produced 50% less power due to the slower loading rate. The results show the potential of developing a triboelectric energy harvesting-based self-powered instrumented knee implant for long-term <italic>in vivo</italic> knee joint force measurement.
THE EFFECT OF SELF EFFICACY AND BIG FIVE PERSONALITY TRAITS TOWARDS ENTREPRENEURIAL INTENTION ON INTERNATIONAL BUSINESS MANAGEMENT – INTERNATIONAL CLASS STUDENTS IN UNIVERSITAS CIPUTRA

Indonesia has been trying to increase their entrepreneur number due to government effort to open more job vacancies, boosting start ups. Universitas Ciputra is one of Indonesia’s leading entrepreneur-based universities which contribute actively since 2006 to solve this problem. One way to increase the number of entrepreneurs in Indonesia is by understanding the entrepreneurial intention for building new start ups. The purpose of this study is to examine the effect of selfefficacy and the big five personality traits towards entrepreneurial intention on International Business Management Students – International Class in Universitas Ciputra as a sample of this study. The data was collected using quantitative method, distributing a questionnaire to 138 and 57 respondents responded, which then processed using linear regression analysis. The research result shows that among the six traits, there are two variables which significantly influence entrepreneurial intention, which are: self-efficacy and conscientiousness. This study is expected to help broaden the horizon of Entrepreneur-based universities in selecting the new enrolled batch based on their entrepreneurial traits prior engaging within the education process.
Can Zakat Charity Help Reduce Economic Inequality? An Agent Based Simulation

Purpose – This paper suggests an agent based model of economic behavior based on which it argues that the Islamic charity of Zakat can be rationalized as it significantly reduces wealth inequalities. Design/methodology/approach – An Agent Based Model (ABM) of wealth distribution (Wilensky, 1998) is configured to introduce Zakat in the model. Simulations were run in the model with ordered and random distribution of Zakat charity and wealth distribution pattern compared with the standard simulation without Zakat. Findings – The impact of this very small charity on the part of the rich (2.5% of net wealth) showed significant impact on wealth distribution pattern as it changed the power law distribution into normal distribution of wealth. Practical implications – The results emphasize non-conventional handling of the economic problem of poverty and wealth signifying the importance of faith based policing Originality/value – The paper contributes an agent based simulation which is a relatively newer technique to study human behavior and is commensurate to complexity theory. Its use is relatively rare in Islamic Economics and the paper is the first to propose a model simulation of Islamic charity of Zakat.
Study of Mixing Different Volume Ratios for Preparing Cu2SnS3 Thin Films using Computerized Spray Pyrolysis System

Ternary thin films was deposited , using a fully computerized system of spray pyrolysis technique, on glass substrates at 310±5 °C. A mixture of an aqueous solution of thiourea, tin chloride dehydrate and copper chloride was used as spraying liquid. The optimum volumetric ratio of mixing was found to be [S/(Cu+Sn)=1] at pH =1.5, in the present work. XRD examination revealed CTS in a monoclinic phase.A number of platform speeds were employed in the spraying process. XRD peaks were described at 2θ = 28.39°, 33.02°, 47.34°, and 56.39° corresponding to , , , and , respectively. The FTIR investigations certified a numeral of the chemical bond of Cu-, Snand S-. The crystallite size was observed in the range of nano-sized using Scherrer formula. Studying surface morphology of CTS films reveals a uniform coating on the substrates which approved by SEM investigations.
Minimum Risk Parity Optimization Using a Quantum or Digital Annealer

In portfolio optimization, many weight allocation strategies result in long-only positions. We show how it is possible to formulate and solve an optimization problem that assigns a direction (long or short) to each weight allocation, such that the variance is minimized or maximized. This optimization problem can then be solved by many solvers, including D-Wave Systems’ quantum annealer, the Fujitsu Digital Annealer, and others. We present backtested results for three datasets solved using a tabu solver run on a CPU. Our results suggest that by utilizing intelligent shorting, this method is able to reduce the volatility of long-only strategies, leading to shorter maximum drawdowns and higher Sharpe ratios, albeit with a higher turnover. We also discuss possible extensions of this model such that it attempts to achieve market neutrality, sector neutrality, or takes into account a shorting aversion.
Empirical Mode Decomposition based Support Vector Regression for Agricultural Price Forecasting

Price information is a crucial market information for a farmer. The price instability and uncertainty pose a significant challenge to decision makers in making proper production and marketing plans to minimize risk. Agricultural price series cannot be modelled and predicted accurately by traditional econometric models owing to its nonlinearity and nonstationary behaviour. In the present study an attempt has been made to model and predict price series using Empirical Mode Decomposition (EMD) based Support Vector Regression (SVR) model. EMD decomposes the original nonlinear and nonstationary dataset into a finite and small number of sub-signals. Then each sub-signal was modelled and forecasted by SVR method. Finally, all the forecasted values of sub-signal were aggregated to make final ensemble forecast. The effectiveness and predictability of the proposed methodology was verified using Chilli wholesale price index (WPI) dataset as sample. The results indicated that the performance of the proposed model was substantially superior as compared to the standard SVR.
How to compare hearing-aid processing of real speech and a speech-modified stimulus for objective validation of hearing-aid fittings?

Proceedings of the International Symposium on Auditory and Audiological Research (Proc. ISAAR), Vol. 7: Auditory Learning in Biological and Artificial Systems, August 2019, Nyborg, Denmark. Edited by A. Kressner, J. Regev, J. C. -Dalsgaard, L. Tranebjærg, S. Santurette, and T. Dau. The Danavox Jubilee Foundation, 2019. © The Authors. ISSN: 2596-5522. How to compare hearing-aid processing of real speech and a speech-modified stimulus for objective validation of hearing-aid fittings?