Miracle-dz/UniFAR-FTUs huggingface dataset:
$P$-wave coupled channel effects in electron-positron annihilation

P-wave coupled channel effects arising from the DD¯, DD¯*+c.c. , and D*D¯* thresholds in e+e- annihilations are systematically studied. We provide an exploratory study by solving the Lippmann-Schwinger equation with short-ranged contact potentials obtained in the heavy quark limit. These contact potentials can be extracted from the P-wave interactions in the e+e- annihilations, and then be employed to investigate possible isosinglet P-wave hadronic molecules. In particular, such an investigation may provide information about exotic candidates with quantum numbers JPC=1-+. In the mass region of the DD¯, DD¯*+c.c. , and D*D¯* thresholds, there are two quark model bare states, i.e. the ψ(3770) and ψ(4040), which are assigned as (13D1) and (31S1) states, respectively. By an overall fit of the cross sections of e+e-→DD¯, DD¯*+c.c. , D*D¯*, we determine the physical coupling constants to each channel and extract the pole positions of the ψ(3770) and ψ(4040). The deviation of the ratios from that in the heavy quark spin symmetry (HQSS) limit reflects the HQSS breaking effect due to the mass splitting between the D and the D*. Besides the two poles, we also find a pole a few MeV above the DD¯*+c.c. threshold which can be related to the so-called G(3900) observed earlier by BABAR and Belle. This scenario can be further scrutinized by measuring the angular distribution in the D*D¯* channel with high luminosity experiments.
Ultrasensitive Hepatitis B Virus Detection in Blood Using Nano-Porous Silicon Oxide: Towards POC Diagnostics

Early diagnosis of infection like Hep-B virus in blood is important for low cost medical treatment. For this purpose, it is desirable to develop a point of care device which should be able to detect trace quantities of the target molecule in blood. In this paper, we report a nanoporous silicon oxide sensor which is capable of detecting down to 1fM concentration of Hep-B surface antigen in blood without the requirement of any centrifuge or pre-concentration. This has been made possible by the presence of resonant peak in the sensitivity characteristics. This peak is observed to be dependent only on the concentration of the specific antigen and not on the interfering species in blood serum. The occurrence of opposite impedance change within the pores and at the bottom of the pore is responsible for this effect. An electronic interface has also been designed to provide a display of the virus concentration. Keywords—Impedance spectroscopy, Ultrasensitive detection in blood, Peak frequency, Electronic interface.
Fast and accurate multi-view reconstruction by multi-stage prioritised matching

In this study, the authors propose a multi-view stereo reconstruction method which creates a three-dimensional point cloud of a scene from multiple calibrated images captured from different viewpoints. The method is based on a prioritised match expansion technique, which starts from a sparse set of seed points, and iteratively expands them into neighbouring areas by using multiple expansion stages. Each seed point represents a surface patch and has a position and a surface normal vector. The location and surface normal of the seeds are optimised using a homography-based local image alignment. The propagation of seeds is performed in a prioritised order in which the most promising seeds are expanded first and removed from the list of seeds. The first expansion stage proceeds until the list of seeds is empty. In the following expansion stages, the current reconstruction may be further expanded by finding new seeds near the boundaries of the current reconstruction. The prioritised expansion strategy allows efficient generation of accurate point clouds and their experiments show its benefits compared with non-prioritised expansion. In addition, a comparison to the widely used patch-based multi-view stereo software shows that their method is significantly faster and produces more accurate and complete reconstructions.
Video Tourism : A Video Extension to Photo Tourism

Photo tourism is a system which interactively explores an unstructured collection of photographs and reconstructs the viewpoints of the cameras which took each photograph and also produces a sparse point cloud of the scene. This project extends this concept to video, whereby any video taken of the same scene that has been reconstructed can be shown as a trajectory that was taken to capture that video, in both 3D position and orientation (pose). In the same way that users can then manipulate this virtual 3D environment switching between different people’s photographs with varying levels of detail, the following work proposes a method to incorporate video at different viewpoints and how people moved to capture that video.
Comparison of Methods to Estimate Dark Respiration in the Light in Leaves of Two Woody Species

Dark respiration in the light was estimated in leaves of two woody species (Heteromeles arbutifolia Ait. and Lepechinia fragans Greene) using two different approaches based on gas-exchange techniques: the Kok method and the Laisk method. In all cases, dark respiration in the light was lower (P < 0.05) than respiration in darkness, indicating that dark respiration was inhibited in the light. Rates of dark respiration in the light estimated by the Laisk method were 52% higher (P < 0.05) than those estimated by the Kok method. Differences between the methods could be explained by the low ambient CO2 concentrations required by the Laisk approach. The mean value of the inhibition of respiration by light for the two species, corrected for the ambient CO2 concentration effect, was 55%. Despite the differences in leaf characteristics between the species, values of the CO2 photocompensation point, at which the rate of photosynthetic CO2 uptake equaled that of photorespiratory CO2 evolution, were very constant, suggesting an excellent consistency in the results obtained with the Laisk approach.
CLM94, a novel cyclic amide with anti-VEGFR-2 and antiangiogenic properties, is active against primary anaplastic thyroid cancer in vitro and in vivo.

CONTEXT AND OBJECTIVE We have studied the antitumor activity of a novel cyclic amide, CLM94, with anti-vascular endothelial growth factor (VEGF) receptor-2 and antiangiogenic activity in primary anaplastic thyroid cancer (ATC) cells in vitro and in vivo. DESIGN AND MAIN OUTCOME MEASURES CLM94 was tested: 1) in two human cell lines (HMVEC-d, dermal microvascular endothelial cells; and 8305C, undifferentiated thyroid cancer) at 0.001-100 μm; 2) in ATC cells at the concentrations of 10, 30, and 50 μm; and 3) in an ATC cell line (AF) in CD nu/nu mice. RESULTS CLM94 significantly inhibited VEGF receptor-2 and epidermal growth factor receptor phosphorylation in HMVEC-d and proliferation in HMVEC-d and 8305C cells. A significant reduction of proliferation with CLM94 in ATC cells (P < 0.01, ANOVA) and a slight but significant reduction of proliferation with CLM94 30 and 50 μm in normal thyroid follicular cells (P < 0.01, ANOVA) were shown. CLM94 increased the percentage of apoptotic ATC cells dose-dependently (P < 0.001, ANOVA) and inhibited migration (P < 0.01) and invasion (P < 0.001). AF cell line was injected sc in CD nu/nu mice, and tumor masses became detectable 25 d afterward. CLM94 (40 mg/kg · d) significantly inhibited tumor growth (starting 10 d after the beginning of treatment). CLM94 significantly decreased the VEGF-A gene expression in the AF cell line and the VEGF-A protein and microvessel density in AF tumor tissues. CONCLUSIONS The antitumor and antiangiogenic activity of a new "cyclic amide" compound, CLM94, is very promising in ATC, opening the way to a future clinical evaluation.
Reconfigurable Zeroth Order And Half Wave Length Resonator Antenna For Pattern Reconfiguration Using Tunable EBG Structures

A pattern reconfigurable antenna utilizing the property of Zeroth Order resonator mode and the half wavelength patch resonator mode has been presented. To excite the TM01 mode of the patch in the same ZOR frequency, tunable Electromagnetic Band Gap (EBG) structures with proper switch selection has been adopted. It is clear from the simulation that both the ZOR frequency and the patch dominant mode frequency can be tuned at 4.21GHz to achieve the pattern reconfigurable antenna.
The Escherichia coli MutL Protein Physically Interacts with MutH and Stimulates the MutH-associated Endonuclease Activity*

All possible pairwise combinations of UvrD, MutL, MutS, and MutH were tested using the yeast two-hybrid system to identify potential interactions involving mismatch repair proteins. A two-hybrid screen previously identified a physical interaction between MutL and UvrD. Although several other known interactions were not observed, a novel interaction between MutL and MutH was detected. A series of truncations from the NH2 and COOH termini of MutL demonstrated that the COOH-terminal 218 amino acids were sufficient for the two-hybrid interaction with MutH. Removal of a small number of residues from either the NH2 or COOH termini of MutH eliminated the two-hybrid interaction with MutL. Protein affinity chromatography experiments confirmed that MutL, but not MutS, physically associates with MutH. Furthermore, MutL greatly stimulated the d(GATC)-specific endonuclease activity of MutH in the absence of MutS and a mispaired base. Stimulation of the MutH-associated endonuclease activity by MutL was dependent on ATP binding but not ATP hydrolysis. Further stimulation of this reaction by MutS required the presence of a DNA mismatch and a hydrolyzable form of ATP. These results suggest that MutL activates the MutH-associated endonuclease activity through a physical interaction during methyl-directed mismatch repair in Escherichia coli.
Detection of Plasmid-Borne β-Lactamase Genes in Extended-Spectrum β-Lactamase ( ESBL ) and Non-ESBL-Producing Escherichia coli Clinical Isolates

Increasing frequency of infections caused by antibiotic resistant Escherichia coli strains producing extended-spectrum β-lactamase (ESBL) needs to be addressed by continuous surveillance and accurate detection of specific ESBLs genes for more effective treatment. A total of 71 β-lactam drug resistant isolates (26 phenotypically ESBL-producing and 45 non-ESBLproducing) were observed to carry approximately 23 kb plasmids. These isolates were subjected to β-lactamase gene-targeted PCR to detect plasmid-encoded blaTEM, blaSHV, blaCTX-M group1 and blaCTX-M group9 genes. BLAST analysis of amplicons revealed that plasmid-encoded blaTEM is most prevalent in both ESBL and non-ESBL-producing E. coli isolates. Plasmid-encoded blaSHV gene was only detected in 8 non-ESBL-producing isolates and explanation of such observation awaits additional studies to detect the possibility that the gene could be in the chromosomal DNA or to test the prevalence of the plasmid-encoded gene with more isolates. Twelve isolates of the ESBLtype blaCTX-M were identified from phenotypically identified ESBLs, comparable with 13 isolates detected with blaTEM. This observation suggests that the relatively newly emerging ESBL-type CTX-M is continuously increasing as one of the new β-lactamase derivatives among ESBLproducing E. coli in the clinical setting. This study reveals that there is discrepancy between the results of the phenotypic observation and genotypic analysis showing that the presence of ESBL-associated β-lactamase genes may be undetected when using the conventional phenotypic approach. Mutation in these unexpressed genes may result to ESBL antibiotic resistance, suggesting that the unexpressed and undetected genes may serve as reservoir for ESBL genes.
ATP Binding Properties of the Nucleotide-binding Folds of SUR1*

Pancreatic beta cell ATP-sensitive potassium (KATP) channels regulate glucose-induced insulin secretion. The activity of the KATP channel, composed of SUR1 and Kir6.2 subunits, is regulated by intracellular ATP and ADP, but the molecular mechanism is not clear. To distinguish the ATP binding properties of the two nucleotide-binding folds (NBFs) of SUR1, we prepared antibodies against NBF1 and NBF2, and the tryptic fragment of SUR1 was immunoprecipitated after photoaffinity labeling with 8-azido-[32P]ATP. The 35-kDa fragment was strongly labeled with 5 μm 8-azido-[32P]ATP even in the absence of Mg2+ and was immunoprecipitated with the antibody against NBF1. The 65-kDa fragment labeled with 100 μm 8-azido-[α-32P]ATP in the presence of Mg2+ was immunoprecipitated with anti-NBF2 and anti-C terminus antibodies. These results indicate that NBF1 of SUR1 binds 8-azido-ATP strongly in a magnesium-independent manner and that NBF2 binds 8-azido-ATP weakly in a magnesium-dependent manner. Furthermore, the 65-kDa tryptic fragment was not photoaffinity-labeled with 8-azido-[γ-32P]ATP at 37 °C, whereas the 35-kDa tryptic fragment was, suggesting that NBF2 of SUR1 may have ATPase activity and that NBF1 has none or little.
Infants as a commodity in a baboon market

We used data from adult female chacma baboons, Papio cynocephalus ursinus, to provide the first test of hypotheses on interchange trading and the structure of a biological market (Noe ¨ & Hammerstein 1994, Behavioral Ecology and Sociobiology, 35, 1–11) within a primate group. The interchange commodities selected were grooming and handling of infants less than 3 months of age. Patterns of grooming in relation to infant handling showed strong evidence for interchange. Grooming for infant access was initiated by potential handlers and was significantly likely to be nonreciprocated. More critically, the data show that infant ‘supply’ created a market effect: grooming bout duration (the price ‘paid’ for handling) was inversely related to the number of infants present in the group. In addition, there was an inverse relationship between grooming bout duration and the rank distance between mothers and handlers, suggesting that higher-ranking mothers could demand a higher price for infant handling. Where rank distance was high, females were able to handle infants without grooming. Dominance could thus be used to disrupt the infant market effect. If biological markets models are to be fully applicable to primate groups (and those of other social mammals) then the potentially distorting effect of dominance needs to be incorporated into the framework.
Polyphenols and β-glucan interactions through linear adsorption models

The aim of this work was to obtain information about interactions between polyphenols and β- glucan through linear adsorption equilibrium models. Polyphenolic compounds can interact with various food ingredients such as carbohydrates, proteins and lipids and this interactions can affect polyphenol bioactivities. Interactions can be studied through adsorption process at constant temperature and adsorption isotherms can be obtained. In this work the interactions between polyphenols like gallic acid, cyanidin-3- galactoside and cyanidin-3-glucoside and β- glucan as natural dietary fiber were studied through Freundlich's, Langmuir's, Dubinin- Radushkevich's, Tempkin's and Hill's models. Adsorption was carried out through model solutions of different concentrations of polyphenols and β-glucan in 16 hours at 25°C. After the adsorption, unadsorbed polyphenols were separated from adsorbed polyphenols by ultrafiltration. Concentration of unadsorbed polyphenols were determined by spectrophotometric Folin-Ciocalteu method for gallic acid and pH differential method for cyanidin-3-galactoside and cyanidin-3- glucoside. The results of adsorption isotherm parameters showed that adsorption between all polyphenols and β-glucan were physical and all interactions were favorized. Gallic acid showed the highest maximum adsorption capacity onto β- glucan. This study showed that information about interactions between polyphenols and dietary fibers can be obtained through the linear adsorption equilibrium isotherms.
New enzymatic colorimetric assay for total homocysteine.

In 1969, McCully (1) observed that increased plasma homocysteine (Hcy) was linked with vascular disease. Subsequent studies demonstrated that even mild hyperhomocysteinemia is an independent risk factor for cardiovascular, cerebrovascular, and peripheral vascular disease (2)(3)(4)(5)(6)(7)(8). Increased plasma Hcy is associated with a thermolabile variant of 5,10-methylenetetrahydrofolate reductase, smoking, lack of exercise, and excessive use of alcohol and coffee. Plasma or serum total Hcy (tHcy) concentrations are most commonly measured by HPLC (9), which is time- consuming and expensive, and by immunochemical (10)(11)(12) or enzymatic (13) methods, which may not be applicable to all colorimetric-based clinical chemistry analyzers. The thiol group of Hcy allows it to form a disulfide bond with other thiol-containing molecules, such as Hcy itself, cysteine, and the cysteine residue of plasma proteins. Biologic fluids may often contain both reduced and oxidized species of Hcy, and the sum of all the forms of Hcy is usually called total Hcy (tHcy) (14). Most clinical studies concerning Hcy have relied on the measurement of tHcy. An initial chemical reduction step of the sample is inevitable in the tHcy assay. Because reducing agents can interfere with the oxidation of redox indicators, such as Trinder’s reagents and derivatives of methylene blue generally used in diagnostic reagents, methods for tHcy that use these indicators have not been developed. The present method is a new enzymatic colorimetric assay for tHcy in biologic samples. The principle is as follows. In the first step, samples are reduced by dithiothreitol …
Design of digital functional blocks using hybrid memristor structures

The memristor device has emerged as the missing fourth fundamental circuit element after resistor, inductor and capacitor. Various implementations of memristors have been reported, with the one using a TiO2 layer sandwiched between two platinum electrodes considered to be most promising. Because of its very small feature sizes and low power consumption, it is projected to replace CMOS technology in several application areas. Various memory and logic design styles using memristors have been reported. A hybrid technology that combines memristors with CMOS gates is promising, and can be fabricated on the same silicon wafer. The present paper proposes the designs of various functional blocks like multiplexers, encoders and decoders using the hybrid memristor structure, with analyses regarding their design complexities. The design methodology is general, and can be used to synthesize arbitrary functional blocks as well.
Binding and Function of Phosphotyrosines of the Ephrin A2 (EphA2) Receptor Using Synthetic Sterile α Motif (SAM) Domains*

Background: Ephrin A2 (EphA2) Sterile α Motif (SAM) domains undergo phosphorylation at Tyr921, Tyr930, and Tyr960. Results: Recruitment of the Grb7 SH2 domain by EphA2 SAM is phosphorylation site-specific. Conclusion: Tyrosine phosphorylation of the EphA2 SAM domain has wide implications for the differential recruitment of binding partners. Significance: SAM tyrosine phosphorylation imparts specificity to its adaptor protein interactions and network formation, easily studied in vitro. The sterile α motif (SAM) domain of the ephrin receptor tyrosine kinase, EphA2, undergoes tyrosine phosphorylation, but the effect of phosphorylation on the structure and interactions of the receptor is unknown. Studies to address these questions have been hindered by the difficulty of obtaining site-specifically phosphorylated proteins in adequate amounts. Here, we describe the use of chemically synthesized and specifically modified domain-length peptides to study the behavior of phosphorylated EphA2 SAM domains. We show that tyrosine phosphorylation of any of the three tyrosines, Tyr921, Tyr930, and Tyr960, has a surprisingly small effect on the EphA2 SAM structure and stability. However, phosphorylation at Tyr921 and Tyr930 enables differential binding to the Src homology 2 domain of the adaptor protein Grb7, which we propose will lead to distinct functional outcomes. Setting up different signaling platforms defined by selective interactions with adaptor proteins thus adds another level of regulation to EphA2 signaling.
Economic assessment methods for transmission network expansion planning in competitive environments

The optimal transmission system expansion planning is an important part of the overall planning task of electric power system under competitive electricity market environments. As we knew reliability indices for evaluation of the transmission expansion plans are quite mature; but, there is not an exhaustive framework for the economic appraisal of the transmission expansion plans. Therefore, survey on the existing economic appraisal methods and proper classification of them would be very advantageous for the researchers in this area. In addition, in order to rate the effect of future investments in transmission, we need to define a set of indices that show the benefits obtained by the different agents of the market including generators, demands, and the transmission entity. In this paper we classify economic indices in three categories including producer, consumer, and system operator (owner) viewpoint. Each category is composed of several indices which are defined in different system levels. All indices computed and compared for two different expansion plans which have been applied to IEEE 24-bus Reliability Test System. Planning results of transmission network expansion process can be construed in economic terms based on the values of the obtained indices for various scenarios, parameters, and topologies.
Implementation and verification of a cloud-based machine-to-machine data management system

Cloud-computing has recently become a popular alternative to traditional physical server application development and deployment. This is largely due to the inherent scalability and flexibility that cloud infrastructure provides. A cloud-design paradigm demands good programming practice that results in maintainable and performant code. A machine-to-machine (M2M) data management system was implemented on a cloud and verified for functional capability and performance. Empirical results show that excellent performance can be expected when the server is hosted on a commercial cloud infrastructure, providing sufficient evidence that a cloud implementation is a viable framework for actual M2M applications.
K-Theory from a physical perspective

This is an expository paper which aims at explaining a physical point of view on the K-theoretic classification of D-branes. We combine ideas of renormalization group flows between boundary conformal field theories, together with spacetime notions such as anomaly cancellation and D-brane instanton effects. We illustrate this point of view by describing the twisted K-theory of the special unitary groups SU(N).
Performance of organisations treating lean as an ideology

Purpose – British empirical research suggests culture and change have contributed to every lean failure. Whilst prevailing research implies that successful lean implementations lead to a profitable organisation, it focuses upon the low numbers of successful lean conversions. The purpose of this paper is to explore the importance of a suitable change strategy resulting in the likelihood of a triumphant lean implementation.Design/methodology/approach – Predominantly, results from 68 survey questionnaires and seven case studies consisting of both questionnaires and interview schedules were utilised. Subsequently, extensive lean audits were carried out in 20 companies as a comprehensive validating exercise.Findings – The significance of change was evident; a high correlation was found within the audits with successful organizations, suggesting that a triumphant implementation requires a systematic and controlled change strategy.Research limitations/implications – Whilst lean failures are attributable to diffe.