Miracle-dz/UniFAR-FTUs huggingface dataset:
Mesoscopic imaging of glioblastomas: Are diffusion, perfusion and spectroscopic measures influenced by the radiogenetic phenotype?

The purpose of this study was to identify markers from perfusion, diffusion, and chemical shift imaging in glioblastomas (GBMs) and to correlate them with genetically determined and previously published patterns of structural magnetic resonance (MR) imaging. Twenty-six patients (mean age 60 years, 13 female) with GBM were investigated. Imaging consisted of native and contrast-enhanced 3D data, perfusion, diffusion, and spectroscopic imaging. In the presence of minor necrosis, cerebral blood volume (CBV) was higher (median ± SD, 2.23% ± 0.93) than in pronounced necrosis (1.02% ± 0.71), pcorr = 0.0003. CBV adjacent to peritumoral fluid-attenuated inversion recovery (FLAIR) hyperintensity was lower in edema (1.72% ± 0.31) than in infiltration (1.91% ± 0.35), pcorr = 0.039. Axial diffusivity adjacent to peritumoral FLAIR hyperintensity was lower in severe mass effect (1.08*10–3 mm2/s ± 0.08) than in mild mass effect (1.14*10–3 mm2/s ± 0.06), pcorr = 0.048. Myo-inositol was positively correlated with a marker for mitosis (Ki-67) in contrast-enhancing tumor, r = 0.5, pcorr = 0.0002. Changed CBV and axial diffusivity, even outside FLAIR hyperintensity, in adjacent normal-appearing matter can be discussed as to be related to angiogenesis pathways and to activated proliferation genes. The correlation between myo-inositol and Ki-67 might be attributed to its binding to cell surface receptors regulating tumorous proliferation of astrocytic cells.
Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes.

The increased use of copper radioisotopes in radiopharmaceutical applications has created a need for bifunctional chelators (BFCs) that form stable radiocopper complexes and allow covalent attachment to biological molecules. The chelators most commonly utilized for labeling copper radionuclides to biomolecules are analogues of 1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetraacetic acid (TETA); however, recent reports have communicated the instability of the radio-Cu(II)-TETA complexes in vivo. A class of bicyclic tetraazamacrocycles, the ethylene "cross-bridged" cyclam (CB-cyclam) derivatives, form highly kinetically stable complexes with Cu(II) and therefore may be less susceptible to transchelation than their nonbridged analogues in vivo. Herein we report results on the relative biological stabilities and identification of the resulting radiolabeled metabolites of a series of (64)Cu-labeled macrocyclic complexes. Metabolism studies in normal rat liver have revealed that the (64)Cu complex of 4,11-bis(carboxymethyl)-1,4,8,11-tetraazabicyclo[6.6. 2]hexadecane ((64)Cu-CB-TE2A) resulted in significantly lower values of protein-associated (64)Cu than (64)Cu-TETA [13 +/- 6% vs 75 +/- 9% at 4 h]. A similar trend was observed for the corresponding cyclen derivatives, with the (64)Cu complex of 4,10-bis(carboxymethyl)-1,4,7,10-tetraazabicyclo[5.5. 2]tetradecane ((64)Cu-CB-DO2A) undergoing less transchelation than the (64)Cu complex of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid ((64)Cu-DOTA) [61 +/- 14% vs 90.3 +/- 0.5% protein associated (64)Cu at 4 h]. These data indicate that the structurally reinforcing cross-bridge enhances in vivo stability by reducing metal loss to protein in both the cyclam and cyclen cross-bridged (64)Cu complexes and that (64)Cu-CB-TE2A is superior to (64)Cu-CB-DO2A in that regard. These findings further suggest that a bifunctional chelator derivative of CB-TE2A is a highly desirable alternative for labeling copper radionuclides to biological molecules for diagnostic imaging and targeted radiotherapy.
Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group.

BACKGROUND Children with high-risk neuroblastoma have a poor outcome. In this study, we assessed whether myeloablative therapy in conjunction with transplantation of autologous bone marrow improved event-free survival as compared with chemotherapy alone, and whether subsequent treatment with 13-cis-retinoic acid (isotretinoin) further improves event-free survival. METHODS All patients were treated with the same initial regimen of chemotherapy, and those without disease progression were then randomly assigned to receive continued treatment with myeloablative chemotherapy, total-body irradiation, and transplantation of autologous bone marrow purged of neuroblastoma cells or to receive three cycles of intensive chemotherapy alone. All patients who completed cytotoxic therapy without disease progression were then randomly assigned to receive no further therapy or treatment with 13-cis-retinoic acid for six months. RESULTS The mean (+/-SE) event-free survival rate three years after the first randomization was significantly better among the 189 patients who were assigned to undergo transplantation than among the 190 patients assigned to receive continuation chemotherapy (34+/-4 percent vs. 22+/-4 percent, P=0.034). The event-free survival rate three years after the second randomization was significantly better among the 130 patients who were assigned to receive 13-cis-retinoic acid than among the 128 patients assigned to receive no further therapy (46+/-6 percent vs. 29+/-5 percent, P=0.027). CONCLUSIONS Treatment with myeloablative therapy and autologous bone marrow transplantation improved event-free survival among children with high-risk neuroblastoma. In addition, treatment with 13-cis-retinoic acid was beneficial for patients without progressive disease when it was administered after chemotherapy or transplantation.
Cognitive aging and auditory information processing

Over the last decade, much research has been conducted to investigate why older listeners report more difficulty in understanding spoken language than would be expected given their degree of audiometric hearing loss. Of particular relevance to audiological rehabilitation is recent research on older listeners when they are engaged in complex tasks involving the auditory processing of naturalistic signals in realistic social and physical environments. Discourse epitomizes such activity. By understanding age-related and individual differences in perceptual and cognitive performance, we gain important insights into how hearing impairments influence activity and participation in context. In this paper, the problems of older adults as communicators in everyday life are illuminated by studies showing that auditory processing problems affect cognitive processing, Age-related problems in understanding spoken language arc exacerbated by perceptual stressors such as noise and by cognitive stressors such as memory load. It is argued that the significance of these processing problems during discourse depends on social-emotional factors, Therefore, goals for new signal-processing technologies designed for older adults who are hard of hearing can be framed not only in terms of improving signal audibility but also in terms of reducing stress on the listener during information processing. Furthermore, goals for therapeutic interventions can be framed in terms of reducing stress during information processing by modifying behaviors and physical and social environments to achieve the listener's goals.
Transdermal Drug Delivery and Lipid Lamellar Structure in Stratum Corneum

Transdermal drug delivery has many advantages, such as drugs can escape from first-pass effect of liver, non-invasive administration and so on. Moreover, maintenance of prolonged plasma concentration of drugs is considered to be possible. Side effect caused by the rapid increase in plasma concentration is possibly prevented by transdermal administration of drugs. Breaking of administration is easy and frequent administration is needless. Those properties of transdermal drug delivery contribute increase in adherence and QOL.
Optimal control for a class of chaos synchronization with input constraint

Based on Lyapunov stabilization and robust control theory, an optimal guaranteed cost control law for chaos synchronization is proposed in this paper. A polytopic model-parameter uncertain presentation for robust control is applied for the piece-wise linear function which exists in a class of chaotic systems. The optimal control law with input constraint is processed by linear matrix inequality (LMI) solver. The effectiveness of the control law is verified and demonstrated by the chaotic Chua's circuit
Growth strategies in mature destinations : linking spatial planning with product development

To rejuvenate a destination means to develop growth strategies whilst in a phase of maturation or stagnation. Stagnation tendencies have been prevalent in Alpine tourism since the 1980's. In recent years, mature destinations in the Alps have attempted to maintain their appeal by defi ning and inventing new products and promotions rather than by further market penetration. Th e rapid (spatial) growth of tourism enterprises in the 1960's and 1970's in the Alpine destination South Tyrol led to restrictive spatial legislation and as a result, greatly limited the quantitative and qualitative development capacities of hotel businesses in these mature destinations. Consequently, the entrepreneurs in South Tyrol and the surrounding region often perceive spatial planning as a restrictive instrument limiting the growth and strategic planning and development of their enterprises. In 2007, after a period of stagnation, the South Tyrolean legislature opened up possibilities of quantitative growth for tourism enterprises, but connected it with an obligatory spatial planning and strategy concept for the entire municipality. Consequently, the municipality has to justify the declaration of new tourism zones by demonstrating the potential for growth in tourism. Th e aim of this paper is to demonstrate, by way of the three South Tyrolean municipalities, that spatial planning and strategic tourism development are not necessarily confl ictive but that spatial planning, in combination with tourism planning and product development, can be a pro-active and creative tool with an important role in developing and implementing growth in mature destinations. As such, the scope of both spatial planning and product development have been jointly defi ned and tested in a case study.
Improved Multiple-Locus Variable-Number Tandem-Repeat Assay for Staphylococcus aureus Genotyping, Providing a Highly Informative Technique Together with Strong Phylogenetic Value

ABSTRACT We describe an improved multiple-locus variable-number tandem-repeat (VNTR) analysis (MLVA) scheme for genotyping Staphylococcus aureus. We compare its performance to those of multilocus sequence typing (MLST) and spa typing in a survey of 309 strains. This collection includes 87 epidemic methicillin-resistant S. aureus (MRSA) strains of the Harmony collection, 75 clinical strains representing the major MLST clonal complexes (CCs) (50 methicillin-sensitive S. aureus [MSSA] and 25 MRSA), 135 nasal carriage strains (133 MSSA and 2 MRSA), and 13 published S. aureus genome sequences. The results show excellent concordance between the techniques' results and demonstrate that the discriminatory power of MLVA is higher than those of both MLST and spa typing. Two hundred forty-two genotypes are discriminated with 14 VNTR loci (diversity index, 0.9965; 95% confidence interval, 0.9947 to 0.9984). Using a cutoff value of 45%, 21 clusters are observed, corresponding to the CCs previously defined by MLST. The variability of the different tandem repeats allows epidemiological studies, as well as follow-up of the evolution of CCs and the identification of potential ancestors. The 14 loci can conveniently be analyzed in two steps, based upon a first-line simplified assay comprising a subset of 10 loci (panel 1) and a second subset of 4 loci (panel 2) that provides higher resolution when needed. In conclusion, the MLVA scheme proposed here, in combination with available on-line genotyping databases (including http://mlva.u-psud.fr/ ), multiplexing, and automatic sizing, can provide a basis for almost-real-time large-scale population monitoring of S. aureus.
Dynamic spectrum sensing by multiband OFDM radio for interference mitigation

MB-OFDM ultra wideband radio will have to coexist with narrowband radio services that operate over the 3.1-10.6 GHz band. In order to coexist with these other radio systems without becoming a source of harmful interference, MB-OFDM system designers will have to develop methods to dynamically detect their presence so that the appropriate avoidance techniques can be implemented whenever it is determined that MB-OFDM transmissions will pose a source of harmful interference. This paper investigates the feasibility of detecting a downlink transmission from an indoor fixed service (FS) system when the MB-OFDM radio collects measurements over a number of consecutive OFDM symbol periods. The analysis shows that when the fixed service signal received by the MB-OFDM device is at a power level of -98 dBm, that it is possible to achieve a false alarm probability of 10-4 and a missed detection probability of ~10-6 when using the measurements that are obtained over 70 consecutive OFDM symbol periods (~22 us). Since the fixed service sub-channel time duration is 200 us, our results imply that the required measurement time is reasonable with respect to the duration of time that the fixed service signal is on the air
Cardiovascular disease in women, is it different to men? The role of sex hormones

Abstract Cardiovascular disease in women differs in clinical presentation, pathophysiology and prognosis from that in men. The role of estrogens and androgens may help explain such sex dimorphisms, being involved in cardiac function, endothelial function and vascular tone. In particular, the cardioprotective effect of estrogen replacement therapy is observed in postmenopausal women in a time-dependent manner, i.e. when it is initiated at their first menopausal symptoms. Postmenopausal women, beyond aged men, may also benefit from testosterone supplementation therapy. Testosterone has been found to be an effective and safe therapy for elderly women with chronic heart failure. However, further studies are needed to clarify doses and routes of administration of androgens in postmenopausal women.
A change in human faecal flora in response to inclusion of gum arabic in the diet

1. Gum arabic is a water-soluble polysaccharide resistant to human gut enzymes and thus can be described as dietary fibre. 2. Using a most-probable-number technique, estimates were made of total anaerobes and of gum-arabic fermenters in the faeces of a volunteer during a contro1 period and during addition of 10 g gum arabic/d to the diet. Using an enrichment technique, the principal bacteria able to utilize gum arabic as the only carbohydrate source were isolated and characterized. 3. Faecal samples were analysed for undegraded gum arabic and, following acid-hydrolysis, for total sugars. 4. The proportion of the faecal flora able to degrade the gum arabic polymer rose from an initial level of 6.5% to more than 50% during gum-arabic ingestion, and subsequently returned to the control level after ingestion ceased. The principal gum-arabic fermenters were species of Bucteroides and Bifdobucterium. 5. Undegraded gum arabic was not detected in any faecal sample nor were there significant differences in the level of total sugars in acid-hydrolysed faeces between gum arabic and control periods. 6. The results presented indicate a direct and rapid change in faecal flora in response to a specific change in the diet of a human volunteer.
Thermopower and conductivity activation energies in hydrogenated amorphous silicon.

The long range fluctuation model has been widely used to account for the difference in activation energies seen experimentally in dark conductivity and thermopower measurements in hydrogenated amorphous silicon. The authors report on a test of this model using measurements of the conductivity and thermoelectric effects carried out in both open and short circuit configurations. While the thermopower activation energy is less than that of the dark conductivity, the short circuit Seebeck conductivity is found to be nearly identical to the dark conductivity in both activation energy and magnitude, consistent with the long range fluctuation model.
Development of design standards for ground support consoles. AMRL-TR-65-163.

Abstract : Experience gained in using a single standardized ground-support console configuration in the WS 131-B, Hound Dog, is discussed. Other ground console designs for possible standardization in future systems are described in detail. All designs are derived from a basic sit-stand configuration and will accommodate approximately 95% of the USAF male population and approximately 60% of the USAF female population. Each of the consoles can be made from five standard subassemblies. The suggested standard configurations permit engineering design freedom, yet restrict certain dimensional characteristics of the consoles to assure accommodation to the requirements and capabilities of the operator.
Expression of K99 adhesion antigen controlled by the Escherichia coli tryptophan operon promoter

The genetic determinant for the K99 adhesin of enterotoxigenic Escherichia coli B41 [O101:K99] has been cloned as a 7.0-kilobase BamHI-generated DNA fragment into the vector pBR322 by us and others (J. D. A. van Embden, F. K. de Graaf, L. M. Schouls, and J. S. Teppma, Infect. Immun. 29:1125-1133, 1980). Cells harboring one such construction, known as pK99-64, are capable of expressing K99 antigen on the cell surface. We replaced the natural promoter sequence for the gene encoding the K99 pilus subunit with a strong, inducible exogenous promoter, the E. coli tryptophan (trp) operon promoter, to construct the plasmid pBR-TrpK99. E. coli cells harboring pBR-TrpK99 or a similar construction in the plasmid pDR540, known as pKO-TrpK99, upon induction with 3-beta-indoleacrylic acid, produced about fourfold more K99 antigen than did cells bearing pK99-64 with the natural promoter. Expression of the pilus antigen was found to be under control of the tryptophan promoter. Plasmid instability was encountered, however, in cells bearing pKO-TrpK99 when the trp promoter was derepressed. Introduction of the aminoglycoside 3'-phosphotransferase gene of transposable element Tn5 into pKO-TrpK99 to generate pKON-TrpK99 effectively stabilized the plasmid in cells grown under identical conditions in medium containing kanamycin.
Effect of Explicit Language Learning Strategy Instruction on Language-Test and Self-Assessment Scores.

The present article reports on the findings of a study that explored the effect of explicit language learning strategy instruction on the development of English as a foreign language within a higher education setting in mixed language ability groups. The research results indicate that explicit language learning strategy instruction that aimed at enhancing language progress in groups of students that were heterogeneous in terms of initial language ability did not have any statistically significant effect on the development of language knowledge. These results indicate that under certain circumstances (limited course time and heterogeneous language competence levels within groups in particular) the organization of strategy training in the form of a separate module or implicit training in the use of language learning strategies seem to be more appropriate.
Effects of physical activities that induce moderate external loading on bone metabolism in male athletes

Sports characterized by little or moderate weight bearing or impact have a low osteogenic effect. However, the action of such sports on bone turnover remains unclear. The objective of this study was to determine the effect on bone remodelling of physical activities that induce moderate external loading on the skeleton. Thirty-eight male athletes aged 18–39 years (cyclists, n = 11; swimmers, n = 13; triathletes, n = 14) and 10 age-matched sedentary controls aged 22–35 years participated in the study. The study combined measurement of bone mineral density by dual-energy X-ray absorptiometry and bone turnover assessment from specific biochemical markers: serum bone-specific alkaline phosphatase, osteocalcin, urinary type I collagen C-telopeptide and calcium. Compared with the controls and swimmers, adjusted bone mineral density was higher (P < 0.05) in triathletes at the total proximal femur and lower limbs. No differences in bone mineral density were found between cyclists, swimmers and controls. Compared with controls, osteocalcin was higher (P < 0.05) in triathletes and swimmers and urinary type I collagen C-telopeptide was higher in swimmers only. Serum bone-specific alkaline phosphatase was lower (P < 0.05) in cyclists than in all other groups. In conclusion, an osteogenic effect was found only in triathletes, mainly at bone sites under high mechanical stress. Bone turnover differed in athletes compared with controls, suggesting that bone turnover may be sport-practice dependent. Despite some encouraging observations, it was not possible to show that changes in the bone remodelling process were sport-discipline dependent.
Rotation of the central pair microtubules in eukaryotic flagella.

It has been 20 years since the phenomenon of central pair rotation in eukaryotic flagella was reported (Omoto, and Kung, 1979 ). At that time, a model was proposed in which the central pair functions as a distributor to regulate dynein activity among the outer doublet microtubules. The video evidence obtained since then and gathered together in this essay is consistent with this model. Geometric arguments indicate that there must be circumferential and longitudinal regulation of shear forces to produce effective bending motion of an axoneme. Central pair microtubules are ideally situated to perform this regulatory function. The regulation of outer doublet sliding by the central pair, together with the rotation of the latter, where this occurs, may explain the wide diversity of two- and three-dimensional flagellar and ciliary waveforms that is found in organisms using the same basic 9 + 2 structure.
Zeatin Metabolism in Fruits of Phaseolus: Comparison between Embryos, Seedcoat, and Pod Tissues.

Zeatin metabolites were isolated from seedcoats and pod tissues of Phaseolus vulgaris and P. lunatus. The differences observed previously between P. vulgaris and P. lunatus embryos, i.e. the formation of O-ribosyl derivatives in the former and O-glucosyl derivatives in the latter, could also be detected in seedcoats, although the levels of these metabolites were much lower and there was a concomitant increase of breakdown products (adenine, adenosine and AMP). Inner pod wall tissues of both genotypes metabolized zeatin at a slow rate and the major metabolite was the mononucleotide of zeatin. The array of metabolites recovered was not influenced by the extraction method (cold ethanol or modified Bieleski solution).