Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamic visual attention characteristics and their relationship to match performance in skilled basketball players

Background Dynamic visual attention is important in basketball because it may affect the performance of players and thus the match outcome. The goals of this study were to investigate the difference in dynamic visual attention characteristics between highly skilled basketball players and nonathletic college students and to explore the relationship between visual attention and game-related performance among the basketball players. Methods In total, 24 highly skilled basketball players and 24 nonathletic college students participated in a multiple object tracking task. The task was conducted so that either the number of targets that were visually tracked or the speed at which a given number of tracked targets moved was altered to examine the difference in dynamic visual attention characteristics between the basketball players and nonathletic college students. The relationship between visual tracking speed (VTS) and game-related statistics, including assists, steals, mistakes, fouls and points scored recorded for every match during the season, was assessed among the basketball players by using Pearson correlations. Results A significant main effect of target tracking load was observed (P < 0.001), with visual tracking performance significantly decreased as target number increased. In addition, the speed at which the targets moved had a significant effect on visual tracking performance (P < 0.001), with tracking performance significantly decreased as target speed increased. However, no significant difference was observed in the abilities of basketball players and nonathletic college students to simultaneously track up to six targets. By contrast, a significant interaction between group and target speed was found (P < 0.001), with the visual tracking accuracy of basketball players significantly greater than that of college students at the higher target speeds examined (P < 0.001). Among basketball players, there were positive, large, and statistically significant correlations in the accuracy in VTS trials and the number of assists (P < 0.001) and between the accuracy in VTS trials and the number of steals (P < 0.001). Conclusion The advantage of skilled basketball players to handle dynamic visual information in a multiple object tracking task was not attributable to the target number but to the target speed. Those athletes with greater dynamic visual attention were more likely to successfully assist or to steal the ball, enhancing performance of the athlete as well as contributing to a more successful team match. These findings may inform basketball training programs to improve player and team performances during matches.
Emphasizing the Diagnostic Value of Digital Tomosynthesis in Detecting Hip Fractures

Our institution recently implemented the use of digital tomosynthesis (DTS) to workup emergency room patients with suspected hip fractures after initial negative or indeterminate radiographs. Our purpose is to evaluate the diagnostic accuracy of DTS for hip fracture detection. We performed a retrospective review of all DTS studies over a 17-month period (July 2017 to November 2018). The results of the radiographs and DTS were recorded as either positive or negative for fracture based on the radiology report. Our reference standard for a fracture was either confirmation on subsequent CT or MRI from the same visit or documentation of clinical findings supportive of a fracture in the patient’s electronic medical record. For patients with negative DTS who did not undergo subsequent cross-sectional imaging, a missed fracture was excluded if they did not return within 30 days with a confirmed fracture. Among 91 patients, there were 34 confirmed fractures—sites including, 7 femoral necks, 10 pubic rami, and 7 greater trochanters. DTS was positive for fracture in 29 patients; 28 of these fractures were true positives, 6 confirmed on cross-sectional imaging, and 22 confirmed clinically. One false positive was observed in a patient with no clinical evidence of a fracture. Six fractures were not detected by tomosynthesis but confirmed on CT/MRI. The sensitivity and specificity of DTS are 82% and 98%, respectively, compared to that of radiographs alone at 47% and 96%, respectively. DTS is a promising adjunct to radiographs for hip fracture detection in an emergency department.
Texture Analysis of F-18 Fluciclovine PET/CT to Predict Biochemically Recurrent Prostate Cancer: Initial Results

Predicting biochemical recurrence of prostate cancer is imperative for initiating early treatment, which can improve the outcome of cancer treatment. However, because of inter- and intrareader variability in interpretation of F-18 fluciclovine positron emission tomography/computed tomography (PET/CT), it is difficult to reliably discern between necrotic tissue owing to radiation therapy and tumor tissue. Our goal is to develop a computational methodology using Haralick texture analysis that can be used as an adjunct tool to improve and standardize the interpretation of F-18 fluciclovine PET/CT to identify biochemical recurrence of prostate cancer. Four main textural features were chosen by variable selection procedure using least absolute shrinkage and selection operator logistic regression and bootstrapping, and then included as predictors in subsequent logistic ridge regression model for prediction (n = 28). Age at prostatectomy, prostate-specific antigen (PSA) level before the PET/CT imaging, and number of days between the prostate-specific antigen measurement and PET/CT imaging were also included in the prediction model. The overfitting-corrected area under the curve and Brier score of the proposed model were 0.94 (95% CI: 0.81, 1.00) and 0.12 (95% CI: 0.03, 0.23), respectively. Compared with a model with textural features (TI model) and that with only clinical information (CI model), the proposed model achieved 2% and 32% increase in AUC and 8% and 48% reduction in Brier score, respectively. Combining Haralick textural features based on the PET/CT imaging data with clinical information shows a high potential of enhanced prediction of the biochemical recurrence of prostate cancer.
Function and Morphology of the Meibomian Glands Using a LipiView Interferometer in Rotating Shift Medical Staff

Purpose To investigate the function and morphology of meibomian glands (MG) in night shift medical staff (MS). Methods Sixty-two eyes of 31 patients in the MS group and 59 eyes of 31 patients in the control group were consecutively enrolled. All participants completed Ocular Surface Disease Index (OSDI) and Standard Patient Dry Eye Evaluation (SPEED) questionnaires for dry eye severity, as well as Schirmer I and tear break-up time (TBUT) tests. LipiView® II Ocular Surface Interferometer was used for lipid layer thickness (LLT), MG dropout, and partial blink (PB) rate tests. MG expression was measured with an MG evaluator. Results The OSDI score in the MS group was 22.39 ± 13.42, which was significantly higher than that in the control group (9.87 ± 6.64 Z = −3.997, P=0.001). The SPEED score in the MS group was 7.94 ± 3.81, which was significantly higher than in the control group (3.65 ± 2.11, Z = −4.766, P=0.001). There was no significant difference in Schirmer I test between the MS group and control group (Z = −1.346, P=0.178). TBUT in MS group was significantly shorter than that in the control group (Z = −5.201, P=0.001). The mean LLT of the MS group was 55.02 ± 21.17 nm significantly thinner than that of the control group 72.76 ± 21.62 nm (Z = −4.482, P=0.001). MG loss occurred in 45.16% of affected eyes in the MS group and 16.13% of affected eyes in the control group, and the difference was statistically significant (χ2 = 14.352, P=0.001). MG yielding liquid secretion and MG yielding secretion score were significantly lower in the MS group than in the control group (Z = −3.641, P=0.001; Z = −3.146, P=0.001, resp.). There was a negative correlation between mean LLT and SPEED score (Spearman r = −0.363, P=0.045). Conclusions Night shift MS had a higher incidence of MGD compared to day workers.
Evidence Based Prediction and Progression Monitoring on Retinal Images from Three Nations

Purpose The aim of this work is to demonstrate how a retinal image analysis system, DAPHNE, supports the optimization of diabetic retinopathy (DR) screening programs for grading color fundus photography. Method Retinal image sets, graded by trained and certified human graders, were acquired from Saudi Arabia, China, and Kenya. Each image was subsequently analyzed by the DAPHNE automated software. The sensitivity, specificity, and positive and negative predictive values for the detection of referable DR or diabetic macular edema were evaluated, taking human grading or clinical assessment outcomes to be the gold standard. The automated software's ability to identify co-pathology and to correctly label DR lesions was also assessed. Results In all three datasets the agreement between the automated software and human grading was between 0.84 to 0.88. Sensitivity did not vary significantly between populations (94.28%–97.1%) with specificity ranging between 90.33% to 92.12%. There were excellent negative predictive values above 93% in all image sets. The software was able to monitor DR progression between baseline and follow-up images with the changes visualized. No cases of proliferative DR or DME were missed in the referable recommendations. Conclusions The DAPHNE automated software demonstrated its ability not only to grade images but also to reliably monitor and visualize progression. Therefore it has the potential to assist timely image analysis in patients with diabetes in varied populations and also help to discover subtle signs of sight-threatening disease onset. Translational Relevance This article takes research on machine vision and evaluates its readiness for clinical use.
Genes differentially expressed at 1 day, 6 weeks, and 6 months of age in aortas of spontaneously atherosclerotic White Carneau pigeons

GENES DIFFERENTIALLY EXPRESSED AT 1 DAY, 6 WEEKS, AND 6 MONTHS OF AGE IN AORTAS OF SPONTANEOUSLY ATHEROSCLEROTIC WHITE CARNEAU PIGEONS By Suzanne Lee Pearlman University of New Hampshire, May, 2011 Genetics is reported to be the primary causative factor for individuals diagnosed with atherosclerosis, in the absence of known risk factors. The development of atherosclerosis in White Carneau (WC) pigeons is of genetic origin, making it an excellent model to study genetic factors. Representational Difference Analysis (RDA) was used to determine genes differentially upregulated between three ages, at the celiac bifurcation of the aorta in WC pigeons. Genes responsible for spontaneous initiation of atherosclerosis were hypothesized as being differentially expressed at 1 day, while those differentially expressed at 6 weeks and 6 months were related to progression. Multiple candidate genes were upregulated at 1 day, although they were not definitively assigned to initiation. Genes upregulated at 6 weeks reflected increases in protein synthesis, loss of cellular integrity, and changes in muscle contraction. By 6 months, increases in lipid metabolism and changes in energy metabolism from oxidative phosphorylation to glycolysis were apparent.
Transcriptomic analysis highlights cochlear inflammation associated with age-related hearing loss in C57BL/6 mice using next generation sequencing

Background In our aging society, age-related hearing loss (AHL) is the most common sensory disorder in old people. Much progress has been made in understanding the pathological process of AHL over the past few decades. However, the mechanism of cochlear degeneration during aging is still not fully understood. Methods Next generation sequencing technique was used to sequence the whole transcriptome of the cochlea of C57BL/6 mice, a mouse model of AHL. Differentially expressed genes (DEGs) were identified using the Cuffdiff software. GO and KEGG pathway enrichment analyses of the DEGs were implemented by using the GOseq R package and KOBAS software, respectively. Results A total of 731 genes (379 up- and 352 down-regulated) were revealed to be differentially expressed in the cochlea of aged mice compared to the young. Many genes associated with aging, apoptosis, necroptosis and particularly, inflammation were identified as being significantly modulated in the aged cochlea. GO and KEGG analyses of the upregulated DEGs revealed that the most enriched terms were associated with immune responses and inflammatory pathways, whereas many of the downregulated genes are involved in ion channel function and neuronal signaling. Real-time qPCR showed that H2O2 treatment significantly induced the expression of multiple inflammation and necroptosis-related genes in HEI-OC1 cells. Conclusion Using next generation sequencing, our transcriptomic analysis revealed the differences of gene expression pattern with age in the cochlea of C57BL/6 mice. Our study also revealed multiple immune and inflammatory transcriptomic changes during cochlear aging and provides new insights into the molecular mechanisms underlying cochlear inflammation in AHL.
Niviventer confucianus sacer (Rodentia, Muridae) is a distinct species based on molecular, karyotyping, and morphological evidence

Abstract Niviventer confucianus sacer Thomas, 1908, which has been regarded as a subspecies of N. confucianus, was found to be a distinct species from N. confucianus based on molecular, karyotyping, and morphological characteristics in this study. Niviventer c. sacer was found to belong to a distinct phylogenetic clade in phylogenetic tree constructed using the mitochondrial gene Cytb, it clustered with N. bukit (Bonhote, 1903) from Vietnam and N. confucianus (Milne-Edwards, 1871) from Yunnan, but showed a distant relationship with N. confucianus from adjacent areas. The genetic distance between N. c. sacer and N. confucianus was more than 5.8%, reaching the level of interspecific differentiation. The species delimitation indicates that N. c. sacer is a monophyletic group. The karyotype of N. c. sacer (FN = 55, 8m+4st+32t+X(sm)Y(t)) differed from that of N. confucianus (FN = 59, 6m+4sm+2st+32t+X(sm)Y(t)). In terms of morphological features, the length of incisive foramen (LIF) and length of auditory bulla (LAB) of N. c. sacer is significantly larger than that of N. confucianus and N. bukit (P < 0.05) and the proportion of white tail tip to total tail length is significantly longer at N. c. sacer (≥ 1/3) than that at N. confucianus (≤ 1/3). Therefore, integrated analysis confirmed that N. c. sacer is a distinct species of genus Niviventer rather than a subspecies of N. confucianus or N. bukit, namely N. sacer, which is only distributed in Shandong.
Price or Quality? Economic Complexity and the Heterogenous Impacts of RER Misalignments

This paper aims to empirically assess variations in the magnitude of the impact in real exchange rate (RER) misalignments on output growth, subject to countries’ technological and productive capabilities. Heterogeneous regressions using interaction models are undertaken to analyse a sample of 81 countries from 1970-2010. Estimates show that the level of economic complexity (which is used to measure technological and productive capabilities) determines cross-country differences regarding the effects of RER misalignments on countries' long-term growth rates. From these results, it is possible to conclude that exchange rate devaluations are not effective for countries in the higher levels of the technological ladder, whilst an overvalued RER will damage growth in the long run for countries with low levels of economic complexity. These findings indicate that price competition is relevant for less complex economies due the lack of product quality competitiveness. On the other hand, since economies with high economic complexity may easily adapt their productive structure due product differentiation and innovation, the central variable of competitiveness is the quality of the product in international markets. Key-words: economic growth; economic complexity; real exchange rate misalignments; price competitiveness; quality competitiveness; technological capabilities, productive capabilities. JEL Code: O11, O14, O40, L60
Proximate composition and antioxidant activity of Syzygium cumini fruit grown at different regions in Bangladesh

The risk of degenerative diseases decreases with the consumption of high antioxidant containing fruits. This study aimed to analyze the proximate composition and antioxidant activity of pulp and seed of Syzygium cumini. Proximate composition was determined by following the AOAC method. Minerals and heavy metals were analyzed using a flame photometer and an atomic absorption spectrometer. In-vitro antioxidant activity was evaluated by using phosphomolybdenum, ferrous ion chelating ability assay and reducing power assay methods. In proximate composition analysis pulp contained significantly (p<0.05) greater amount of minerals than seed but seed contained a higher amount of protein and lipid than pulp. In the bioactive compound analysis, seed extracts possessed significantly (p<0.05) greater amount of Chlorophyll A, Chlorophyll B and total carotenoids. Additionally, seed extracts exhibited significantly (p<0.05) more total antioxidant capacity, reducing power and ferrous ion chelating ability compared to pulp extracts. This study revealed that the seed of Syzygium cumini contains significantly (p<0.05) higher amount of minerals, bioactive compounds and showed better antioxidant property. Therefore, Syzygium cumini seed can be a potential source of natural antioxidant in medicine and food production.
Severity Prediction for COVID-19 Patients via Recurrent Neural Networks

The novel coronavirus disease-2019 (COVID-19) pandemic has threatened the health of tens of millions of people worldwide and posed enormous burden on global healthcare systems. In this paper, we propose a model to predict whether a patient infected with COVID-19 will develop severe outcomes based only on the patient's historical electronic health records (EHR) using recurrent neural networks (RNN). The predicted severity risk score represents the probability for a person to progress into severe status (mechanical ventilation, tracheostomy, or death) after being infected with COVID-19. While many of the existing models use features obtained after diagnosis of COVID-19, our proposed model only utilizes a patient's historical EHR to enable proactive risk management at the time of hospital admission
Climate-Driven Range Shifts of Brown Seaweed Sargassum horneri in the Northwest Pacific

Climate-driven shifts of coastal species’ ranges constitute a key factor shaping both the vegetation composition and biodiversity of coastal ecosystems. Although phylogeographic studies relying on genetic data have shed light on the evolutionary history of macroalgae along the Northwest Pacific (NW-Pacific) coast, their distribution dynamics are less understood and require interdisciplinary examination. Here, we used a combination of species distribution models (SDMs) and genetic data to explain the causes of population persistence and genetic differentiation and their consequences for the brown seaweed Sargassum horneri in the NW-Pacific. In this region, the phylogeographic structure of S. horneri was analyzed by screening 72 populations spawning across the entire coastal distribution and obtaining their mtDNA cox3 data. Population genetic structure and SDMs based on paleoclimatic data consistently revealed that southern coasts of the Sea of Japan, North-Pacific-Japan, and the northern part of Okinawa Trough might have served as potential refugia for S. horneri during the Last Glacial Maximum (LGM). Furthermore, we projected the distribution dynamics of S. horneri under future climate scenarios. The range of S. horneri was predicted to move northward, with a significant loss of suitable habitat, under the high emissions scenario (RCP 8.5). By contrast, projected range shifts were minimal under the low emissions scenario (RCP 2.6). Furthermore, North-Pacific-Japan was projected to be long-term persistence habitat for S. horneri under future climatic conditions, thus including this area in conservation planning could help mitigate for climate change implications. Our results enable a better understanding of the impacts of climate change on the spatio-temporal distribution of macroalgae and how this can inform coastal management and marine conservation planning.
Cerebrovascular Reactivity Assays Collateral Function in Carotid Stenosis

In patients with carotid artery stenosis (CAS), the risk of stroke, its severity, and response to revascularization are strongly related to the availability of collateral blood flow. Unfortunately, there is poor agreement between observers in assessing collateral flow using flow-based imaging. We used changes in blood-oxygen-level-dependent (BOLD) MRI as a surrogate of changes in regional cerebral blood flow in response to a hypercapnic stimulus [i.e., cerebrovascular reactivity (CVR)] as indicating flow reserve ipsilateral to CAS. We hypothesized that some patients with hemodynamically significant CAS develop functional collateral flow as indicated by normalization of ipsilateral CVR. We identified 55 patients in our CVR database with various degrees of CAS assessed by angiography and classed them as <50% stenosis, 50–69% stenosis, 70–90% stenosis, >90% stenosis, and full occlusion. CVR was measured as the change in BOLD signal in response to changes in end-tidal partial pressure of CO2 (Δ BOLD/Δ PETCO2) and normalized voxel-wise relative to the mean and standard deviation of the CVR in the corresponding voxels of an atlas of 46 healthy controls (CVR z scores). CVR and z scores were then averaged over gray matter (GM) and white matter (WM) on each side of the middle cerebral artery (MCA) territory. As hypothesized, CVR varied for each severity of CAS. Ipsilateral MCA territory CVR was less than normal in each class, including that with <50% stenosis (Student t-test, two-tailed; p = 0.0014 for GM and p = 0.030 for WM), with a trend of decreasing average CVR with increasing stenosis. Remarkably, the considerable individual variability in MCA CVR included some patients with normal CVR in each class – including that with complete occlusion. We conclude that, in general, CAS depresses downstream vascular reserve, but the extent of collateralization is highly variable and not predictable from the degree of stenosis, including both <50% stenosis and complete occlusion. CVR may be the more reliable marker for recruitable collateral blood flow than degree of CAS.