Miracle-dz/UniFAR-FTUs huggingface dataset:
Vítor Constâncio: Investment and growth in advanced economies selected takeaways from the ECB's Sintra Forum

The European Central Bank’s 2017 Sintra Forum on Central Banking built a bridge from the currently strengthening recovery in Europe to longer-term growth issues for and structural change in advanced economies. In this column the organisers highlight some of the main points from the discussions, including what the sources of weak productivity and investment are and what type of economic polarisation tendencies the new growth model seems to be associated with. main themes that keenly 2017: the productivity slowdown; the implications of for explaining the laggard post-crisis recovery; sources of weak investment; the complementarity between demand and supply policies; and relevant aspects of the broader societal context. The full set of papers, discussions and speeches can be found on the Sintra Forum website while video recordings of all sessions are on the ECB’s YouTube channel .
Dead-beat current control for active filters

The paper discusses the main issues concerning the implementation of digitally controlled parallel active power filters. The considered control strategy is based on the combination of dead-beat control of inverter currents and space vector modulation. For an active filter application, key features of the power converter's control are the achievable harmonic compensation quality (TEC standards compliance) and the robustness of the system's stability (load structure and parameter uncertainty). Both aspects are examined in the paper. As far as the former is concerned, simulations and experimental tests show that even if a high switching frequency is achieved (using a state-of-the-art DSP platform), the intrinsic calculation delay of the dead-beat algorithm represents a serious hurdle for the achievement of a satisfactory compensation quality. From the stability standpoint instead, the effects of parameter mismatches on the system's performance are investigated by means of a complete eigenvalue analysis, which allows to reveal the limits of the system's stability for different possible implementations of the considered control strategy.
Relationships among Problem Drinking Behavior, AUDIT, Drinking Motivation, Coping Style and Stress in Male University Students

This study was carried out to identify the relationships among problem drinking behavior, AUDIT, drinking motivation, coping style and stress in male university students. The most relevant variable with problem drinking behaviors was the alcohol use disorder level. Thus the higher the AUDIT score, the more problem drinking behaviors occurred. The higher the level of coping motive and enhancement motive as the sub-domains of drinking motivation, the level of detached coping and emotional coping as the sub-domains of coping type, and stress level, the more problem drinking behaviors occurred. In addition, the higher the level of social motivation as the sub-domain of drinking motivation, the less problem drinking behavior occurred. Therefore, it is necessary to develop programs and interventions to manage problem drinking behaviors in high risk group diagnosed through Alcohol Use Disorder Identification Test (AUDIT). In addition, by reflecting the drinking motivation and coping styles and stress management that are related to the problem drinking behaviors in the contents of drinking health education and programs, the correct drinking culture of male college students should be established.
Characterization of the Human Immunoglobulin Kappa Gene 3' Enhancer: Functional Importance of Three Motifs That Demonstrate B-Cell-Specific In Vivo Footprints

Using a combination of in vivo footprinting and site-directed mutagenesis, we have functionally characterized an enhancer located 12 kb downstream of the human immunoglobulin kappa constant-region gene. The core enhancer region is highly homologous to the murine 3'K enhancer. However, in addition to two regulatory elements homologous to the functional motifs of the murine enhancer, we find a third positive regulatory element in the human enhancer. This element is associated with an 11/12-bp direct repeat (DR) that is well conserved in the murine locus but was not recognized as functionally important in the murine enhancer. Mutation of any of the three motifs of the human enhancer decreases its activity to 3 to 20%o of the wild-type level, indicating cooperative interaction between these elements. The DR motif does not resemble any known enhancer element and does not appear to function as a transcriptional activator on its own when present in multiple copies. Interestingly, nuclear extracts from both B- and T-cell lines contain factors binding to DR in vitro, but in vivo footprinting shows no evidence ofprotein-DNA binding in the T-ceil line. This finding suggests that an additional regulatory mechanism, such as the effect ofchromatin configuration on accessibility, may be involved in the B-cell-restricted activity of the human 3'K enhancer. The expression of immunoglobulin (Ig) genes is restricted to cells of the B-cell lineage and represents a model system for the study of tissue-specific gene regulation. Ig K light-chain expression is regulated at the transcriptional level by a
VISUALLY ENHANCED ANALYSIS OF REFUGEES’ SOCIAL MEDIA ACTIVITIES IN TURKEY

The population of refugees in Turkey is significantly growing since 2014 and it has already exceeded three millions. This situation urges to study their conditions and issues as well as their opinions. In this study, we propose a method to analyze the dataset collected from social media accounts of refugees in Turkey in a textual and visual manner. Firstly, we acquire social media activities of refugees
Identification of Ferroptosis-Related Hub Genes and Their Association with Immune Infiltration in Chronic Obstructive Pulmonary Disease by Bioinformatics Analysis

Purpose Ferroptosis and immune infiltration are involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). We aim to identify ferroptosis-related hub genes and analyze their association with immune infiltration in COPD through bioinformatics methods. Materials and Methods The mRNA microarray data of GSE38974 were downloaded from Gene Expression Omnibus to obtain differentially expressed genes (DEGs). The DEGs were intersected with ferroptosis-related genes (FRGs) from FerrDb to obtain differentially expressed FRGs. GO and KEGG enrichment and protein–protein interaction (PPI) analyses of differentially expressed FRGs were conducted in R software and STRING database. The key module and hub genes were screened by Cytoscape software. MiRNAs, transcription factors and signal molecules were predicted in miRNet and NetworkAnalyst. The disease correlation in the Comparative Toxicomics Database (CTD) and the receiver operating characteristic (ROC) curves of hub genes were analyzed. Immune infiltration was evaluated by CIBERSORT algorithm. Spearman correlation analyses were conducted between hub genes and differentially infiltrated immune cells. Results Fifteen differentially expressed FRGs were identified, which were enriched in some terms involving airway inflammatory responses and structural remodeling. Five hub genes were selected including HIF1A, IL6, PTGS2, CDKN1A and ATM. Inference scores in CTD indicated their association with COPD. Two miRNAs, five transcription factors and one signal molecule were predicted. The combination of hub genes could be a fine diagnostic indicator of COPD (AUC: 0.981, CI: 0.940-1.000). Immune infiltration evaluation showed that monocytes and M0 macrophages were upregulated in COPD lung tissues, while CD8 T cells, activated NK cells, M2 macrophages, resting dendritic cells and resting mast cells were downregulated. The hub genes were significantly associated with differentially infiltrated immune cells. Conclusion We identified five ferroptosis-related hub genes (HIF1A, IL6, PTGS2, CDKN1A and ATM) in COPD, and found that they may influence the pathogenesis of COPD by regulating ferroptosis and thus affecting infiltrating immune cells.
EFFECTS OF ENVIRONMENTAL ENRICHMENT ON SEROTONERGIC AND DOPAMINERGIC RESPONSES TO PSYCHOSTIMULANTS: A PARALLEL STUDY IN ANIMAL MODEL OF ADDICTION STRESS AND DEPRESSION

Received: Revised: Accepted: Published online: December 29, 2016 June 15, 2017 July 11, 2017 July 25, 2017 Post-exposing the rats to enriched environment has shown to attenuate the psychoneurological and behavioral deficits produced as a result of chronic stress in rats. But here we studied the possibility whether the pre-exposure of enriched environment might affect the behavioral deficits produced as a post-treatment to chronic restraint stress. Behavioral parameters, associated with chronic stress such as depression, anxiety and memory were monitored before and after stress treatment, in socially enriched and socially non-enriched conditions. According to the results the rats that were pre-exposed to socially enriched conditions indicated an anti-depressive and anxiolytic activity after repeated stress procedure as compared to the rats of socially non-enriched environment. Furthermore, improvement and retention of short term and long term memory was observed in enriched rats before and after restraint stress procedure. This study can be related to the beneficial role of earlier exposure to enriched environment that may affect the behaviors related to response of brain to stress stimuli and prevention of behavioral deficits that may lead to various psychological abnormalities that are related to prolonged stress exposures. ©2017 PVJ. All rights reserved
Growth Characteristics of Free C1498 (Granulocytic Leu

Subcutaneous implants of C1498 tumor grow as diffuse, soft tissue, with indefinite edges, closely adherent to the skin, spreading into muscle and invading peripheral blood and hematopoietic or gans. The histologic type of tumor and the cytologic characteristics of tumor cells in the blood were identified as granulocytic leukemia. ' The tumor was used for immunogenetic (6) and immunologi cal (7) studies. It seemed to us that various growth types of these cellsâ€”tumor tissue formation, blood invasion, infiltration of organs, growth in the pleural exudate (@)â€”indicate their exceptionally high ability to grow and to migrate as free cells in body fluids. We have studied, therefore, the growth potentialities of C1498 tumor cells, using our method of free tumor cell culture in peritoneal fluid (1). Moreover, in an attempt to assay the
Microbial Synthesis of Silver Nanoparticles Using Alternaria alternata and Their Characterization

In this study, extracellular biosynthesis of silver nanoparticles (AgNPs) was carried out using Alternaria alternata . AgNPs were synthesized using vegetative and cell-free filtrate methods. Silver nitrate (AgNO 3 ) solution was reduced with fungal mycelial mass and cell-free filtrate at a ratio of 1:4 (v/v). Further, the effects of biosynthesis parameters (reaction time, reaction temperature, light and dark incubation, and static and agitated conditions) were determined. The structural integrity of the synthesized AgNPs was investigated through UV-visible spectrophotometry, X-ray diffraction (XRD) analysis, and transmission electron microscopy (TEM). Parameter optimization revealed that cell-free filtrate AgNP synthesis at 40 °C with constant agitation and incubation in darkness for 120 h using 1 mM AgNO 3 resulted in the highest absorbance value (at 400 nm). Further, TEM images showed that the synthesized AgNPs were spherical, homogeneous, and well dispersed while the XRD peaks confirmed the purity of the AgNPs obtained. The diameters of the AgNPs were found to range from 7.48 to 12.15 nm. This study identifies Alternaria alternata as a potential candidate for use in the industrial biosynthesis of AgNPs.
Electrical energy management in small, and medium size industries

There is a general awareness of the opportunities for reducing the cost of electricity consumption in industry, but the progress in implementation has been slow and stagnant, particularly in the small and medium size industries. Part of the reason for the slow progress is lack of information on methodologies for the electrical energy management in industries. The paper discusses common aspects of electrical energy management in small and medium size industries. It contains the finding and the analysis of the results obtained from the electrical energy audit program which is done in various industries. The analyses are focused on the load management, power factor management, transformers analysis and motor losses management. <<ETX>>
The Stability of Plasma-Sprayed MnCo 2 O 4 Coatings at Elevated Temperature for Protective Application of Solid Oxide Fuel Cells

on the microstructure of spinal coatings. In this work, commercial spinal powder is used as raw material to prepare spinal coatings by plasma spray process. MnCo 2 O 4 spinel coatings are obtained with controlled spray conditions. The conductivity of obtained MnCo 2 O 4 spinel coatings are measured. The stability and microstructure of spinel coatings are characterized. The effect of heating treatment on spinel coatings is estimated. Abstract As one of the most promising candidates to provide metallic interconnector the ability against oxidization at elevated temperature, conductible spinel has drawn a lot of attention in recent years. However, it is suffering poor stability during the preparation process, such as plasma spray. This work is proposed to concentrate on the preparation of highly conductible spinel coating. MnCo 2 O 4 spinel coatings are successfully obtained by atmospheric plasma spray. Conductivity test is carried out at 700°C with duration up to 15 hours. Stability and variation in microstructure are characterized by SEM, XRD, TEM and differential scanning calorimetry (DSC). Resultantly, coatings are found intensively densified that cracks and gaps are expelled, and number of pores is reduced. The as-sprayed coatings are found of more CoO and less MnCo 2 O 4 , while the densified coatings are composed of more MnCo 2 O 4 and less CoO. The measured conductivity of samples is 7.99S/cm, 4.00S/cm and 39.4S/cm for sample No.1, No.2 and No.3 respectively. Sample No.3 exhibit the best stability with the lowest specific heat flux of 0.8mW/mg and the biggest average grain size of 227nm while the specific heat flux of sample No.2 is as high as 1.8mW/ mg and the average grain size is 83nm. Both the densification, phase composition and the grain size contribute to the conductivity of the coatings.
PROM_A_306352 117..128

1Department of Respiratory Medicine, Respiratory Research Unit, Hvidovre University Hospital, Hvidovre, Denmark; 2Institute for Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; 3Innovation and Research Centre for Multimorbidity, Slagelse Hospital, Slagelse, Denmark; 4Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark; 5Department of Physical & Occupational Therapy, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark Introduction: In patients with COPD, the COPD Assessment Test (CAT), Clinical COPD Questionnaire (CCQ), Hospital Anxiety and Depression Scale (HADS) and EuroQol 5D (EQ-5D-3L) are widely used patient reported outcome measures (PROMs) of respiratory symptoms, anxiety, depression and quality of life. Despite established validity, responsiveness and minimal important change (MIC), the reproducibility and especially important agreement parameters remain unreported in these frequently used PROMs. The aim of this study was to investigate the inter-day test–retest reliability and agreement of the CAT, CCQ, HADS and EQ-5D-3L in patients with severe and very severe COPD (FEV1 <50%) eligible for hospital-based pulmonary rehabilitation. Patients and Methods: Fifty patients (22 females, mean [SD] age 67 [9] yrs.; FEV1 32[9] %; 6-minute walk distance 347 [102] meters; CAT 21 [6] points; BMI: 26 [6] kg/m) completed the questionnaires (CAT, CCQ, HADS, EQ-5D-3L) in combination with functional performance test instructed by one assessor on test-day one (T1) and by another assessor 7–10 days later on testday two (T2). Results: The inter-day test–retest reliability ICC was 0.88 (LL95CI: 0.80) for CAT; 0.69 (LL95CI: 0.46) for CCQ; 0.86 (LL95CI: 0.75) and 0.90 (LL95CI: 0.82) for HADS-anxiety (A) and depression (D) and 0.87 (LL95CI: 0.76) for EQ-5D-VAS. The corresponding agreements within a single measurement (standard error of measurement, SEM) and for repeated measurement errors (smallest real difference, SRD) were respectively 2.1 and 2.9 points for CAT; 0.5 and 0.7 points for CCQ total; 1.3 and 1.9 points for HADS-A; 0.9 and 1.3 points for HADS-D and 6.8 and 9.7 VAS-score for EQ-5D-3L, respectively. Ceiling/flooring effect was present in <5% for all questionnaires. Conclusion: In patients with severe and very severe COPD, the CAT, CCQ, HADS and EQ5D-3L questionnaires presented moderate to excellent inter-day test–retest reliability, and no floor or ceiling effect was documented for any of the questionnaires. Only CAT and HADS had an acceptable SRD below the established MIC for assessing change over time on group level, and none of the PROMS were fit to assess individual changes over time.
Molecular Dynamics Simulations of Small-Molecule Inhibitors of β-Amyloid Aggregation

Amyloid aggregation is linked to a number of neurodegenerative syndromes, the most prevalent one being Alzheimer’s disease. In this pathology, the b-amyloid peptides (Ab) aggregate into oligomers, protofibrils, and fibrils and eventually into plaques, which constitute the characteristic hallmark of Alzheimer’s disease. Several low-molecular-weight compounds able to impair the Ab aggregation process have been recently discovered; yet, a detailed description of their interactions with oligomers and fibrils is hitherto missing. Here, molecular dynamics simulations are used to investigate the influence of two relatively similar tricyclic, planar compounds, that is, 9, 10-anthraquinone (AQ) and anthracene (AC), on the early phase of the aggregation of the Ab heptapeptide segment H14QKLVFF20, the hydrophobic stretch that promotes the Ab self-assembly. The simulations show that AQ interferes with b-sheet formation more than AC. In particular, AQ intercalates into the b-sheet because polar interactions between the compound and the peptide backbone destabilize the interstrand hydrogen bonds, thereby favoring disorder. The thioflavin T-binding assay indicates that AQ, but not AC, sensibly reduces the amount of aggregated Ab1–40 peptide. Taken together, the in silico and in vitro results provide evidence that structural perturbations by AQ can remarkably affect ordered oligomerization. Moreover, the simulations shed light at the atomic level on the interactions between AQ and Ab oligomers, providing useful insights for the design of small-molecule inhibitors of aggregation with therapeutic potential in Alzheimer’s disease.
Mechanical Properties of Recycled Aggregate Concrete Modified by 1 Nano-particles 2

15 In this study, different nano-particles were used to modify recycled aggregates concrete (RAC) 16 containing recycled clay brick aggregates (RCBAs) to improve the RAC properties. Two 17 stages of experimental works were performed. In the first stage, various nano-particle 18 mixtures produced by different mixing methods, i.e. the use of surfactant and ultrasonication, 19 were examined by optical microscope to evaluate the dispersion of the nano-particles in water 20 liquid. The nano-particles modified cement mortar specimens were further evaluated by 21 flexural tensile test to check how these mixing methods affect the properties of the 22 nano-particle modified cement mortar. In the second experimental stage, the effects of four 23 replacement ratios of recycled aggregates, three type of nano-particles, two mixing methods 24 of RAC, additional surfactant and ultrasonication process used in the mix of nano-particle 25 liquid, and the dosages of the nano-particles on the workability, compressive and split tensile 26 properties of the nano-particle modified RAC were investigated.
DEPENDABLE FLOW ANALYSIS IN LEMATANG WEIR

— Water resources are needed currently very much, especially in the area of Kota Pagar Alam for the purposes of rice fields which are planned to be served by Lematang Weir. The purpose of this study is to determine water availability to calculate dependable flow in Lematang Weir by using the Hydrology Engineering Center-Hydrologic Modeling System (HEC-HMS) model. The Lematang Weir watershed is influenced by land cover and average monthly rainfall which ranges from 7.13 mm in 2018, based on rainfall data which is taken from satellite rainfall data (TRMM). Based on mapping analysis and Geographical Information System (GIS) software, the Lematang Weir watershed is obtained covers an area is 59.889 km 2 . By using HEC- HMS software, the simulation results to show that the Q80 dependable flow in the Lematang Weir watershed is 1 m 3 /s and Q90 is 0.70 m 3 /s.
THE MICROBIAL COMMUNITY COMPOSITION OF AN ANAEROBIC REACTOR IN A SUGAR INDUSTRY WASTEWATER TREATMENT PLANT-FROM CLASSICAL TO NEW APPROACHES

: In this study, the microbial characteristics of the anaerobic reactor of a sugar industry wastewater treatment plant were analyzed using cloning, FISH (Fluoresan in situ hybridization) and metagenomic analysis. Samples were obtained from seven different ports of the reactor on the 148 th day of operation. The temperature was maintained at mesophilic conditions. The system’s pH range was operated at 6.8. The cloning results showed that most of the bacterial clones belonged to uncultured members of the Bacteria domain. Many archaeal clones were related to uncultured Archaea and Methanosarcina . The FISH method was applied to determine the microbial composition of the samples, which showed that bacterial and archaeal species had nearly equal rates. Rod-shaped cells, long bacilli, coccus and long chains were detected in the samples. After metagenomic analysis, in all samples, Archaea domain members ranged between 60-36% and Bacteria domain members ranged between 58-31%. At the phylum level, in all samples, Euryarchaeota was the most dominant phylum. Proteobacteria (14.8-21.97%) and Actinobacteria (5.53-15.94%) phyla were high in rate. Furthermore, members of Spirochaeotes (0.63-4.82%) and Bacteroidetes (1.72-2.38%) were analyzed in the samples. This study revealed both bacterial and archaeal populations in the reactor of high-concentration organic sugar wastewater. These results will help in the development of more efficient anaerobic treatment systems
Experimental and numerical study on innovative seismic T-Resisting Frame (TRF)

In common structural systems, there are some limitations to provide adequate lateral stiffness, high ductility, and architectural openings simultaneously. Consequently, the concept of T-Resisting Frame (TRF) has been introduced to improve the performance of structures. In this study, Configuration of TRF is a Vertical I-shaped Plate Girder (V.P.G) which is placed in the middle of the span and connected to side columns by two Horizontal Plate Girders (H.P.Gs) at each story level. System performance is improved by utilizing rigid connections in link beams (H.P.Gs). Plastic deformation leads to tension field action in H.P.Gs and causes energy dissipation in TRF; therefore, V.P.G. High plastic deformation in web of TRF\'s members affects the ductility of system. Moreover, in order to prevent shear buckling in web of TRF\'s members and improve overall performance of the system, appropriate criteria for placement of web stiffeners are presented in this study. In addition, an experimental study is conducted by applying cyclic loading and using finite element models. As a result, hysteresis curves indicate adequate lateral stiffness, stable hysteretic behavior, and high ductility factor of 6.73.