Miracle-dz/UniFAR-FTUs huggingface dataset:
Purification of Andrographolide Methanolic Extract Using Molecularly Imprinted Polymer Prepared by Precipitation Polymerization

Molecularly Imprinted Polymer (MIP) has a specific cavity in which the conformity of shape, size, and functionalities corresponds with its template molecule and has been widely used in separation processes. Therefore, this study aims to examine the application of MIP for the purification of andrographolide. The MIP was synthesized by precipitation polymerization using methacrylic acid (MAA) and ethylene glycol dimethacrylate (EGDMA) as the functional monomer and cross-linker, andrographolide as a template, and acetonitrile:toluene (3:1) as porogen solvent. The results showed that the binding capacity of Synthesized MIP was 1.2486 mg/g, while the particle size was 295.5 nm with a polydispersity index of 0.064. Furthermore, the imprinting and selectivity factors were 1.148 and 12.37, respectively. The purification process by MIP increased the purity from 55.37 ± 0.69 to 94.94% ± 0.34, while the isolate characterization showed that purified andrographolide had a similar character compared to the standard.
Overcoming Chemotherapy Resistance in Germ Cell Tumors

Testicular germ cell tumors (GCTs) are highly curable malignancies. Excellent survival rates in patients with metastatic disease can be attributed to the exceptional sensitivity of GCTs to cisplatin-based chemotherapy. This hypersensitivity is probably related to alterations in the DNA repair of cisplatin-induced DNA damage, and an excessive apoptotic response. However, chemotherapy fails due to the development of cisplatin resistance in a proportion of patients. The molecular basis of this resistance appears to be multifactorial. Tracking the mechanisms of cisplatin resistance in GCTs, multiple molecules have been identified as potential therapeutic targets. A variety of therapeutic agents have been evaluated in preclinical and clinical studies. These include different chemotherapeutics, targeted therapies, such as tyrosine kinase inhibitors, mTOR inhibitors, PARP inhibitors, CDK inhibitors, and anti-CD30 therapy, as well as immune-checkpoint inhibitors, epigenetic therapy, and others. These therapeutics have been used as single agents or in combination with cisplatin. Some of them have shown promising in vitro activity in overcoming cisplatin resistance, but have not been effective in clinical trials in refractory GCT patients. This review provides a summary of current knowledge about the molecular mechanisms of cisplatin sensitivity and resistance in GCTs and outlines possible therapeutic approaches that seek to overcome this chemoresistance.
Hand-foot Syndrome Due to Capecitabine: Report of Two Cases

: Capecitabine is one of the most common chemotherapy drugs known to cause hand-foot syndrome (HFS). It is indicated as adjuvant therapy for the treatment of colorectal cancer, first-line therapy in metastatic colorectal cancer, and as monotherapy or in combination with docetaxel in metastatic breast cancer. Although considered to be safe, it has some adverse effect, such as HFS, which is a localized skin eruption associated with the initiation of therapy with certain chemotherapeutic agents. It is considered common and mild thus frequently but improperly self-managed and impaired quality of life. A fifty seven years old woman on treatment with capecitabine for breast cancer and a 46-years-old woman on treatment with capecitabine for breast and thyroid cancer presented with dry and fissured skin on both palms and soles. They also noted pain and discomfort while doing their daily activities. On examination, there were multiple erythematous-hyperpigmented plaques, with scales and fissures overlying it on both palms and soles. Both patients were diagnosed with hand-foot syndrome due to capecitabine and responded well to topical emollients and steroid
The Influence of Leadership Style, Self-learning, and Pedagogical Competence to the Professional Commitment of Kindergarten Teachers in South Jakarta

: The purpose of this study is to investigate the influence of the leadership style, self-learning and pedagogical competence on professional commitment of kindergarten teachers at South Jakarta. The Study usedquantitative approach, path analysis and survey methods. Data is collected via survey questionnairefrom a sample of 95kindergarten teachers. The result of data analysis concluded as follows: First: the leadership style, self-learning and pedagogical competence had a positive direct effect on professional commitment. Second: The leadership style and self-learning had a positive direct effect on pedagogical competence. Third: the leadership style had a positive direct effect on self-learning. Professional commitment is one of important factors that determining behavior of persons and consider from management and training environment. Definition from professional commitment determines three dimensions for affective, continuous and normative professional commitment. Professional commitment is sense of identifying and necessity to continuous work in a job and high responsibility. Therefore, it is important to improve professional commitment by improving the strong leadership style, the willingness of self-learning and pedagogical competence. Based on these findings can be concluded that the Kindergarten teacher’s professional commitment at South Jakarta can be enhanced through improving leadership style, self-learning and pedagogical competence. Implications and limitations of the study are discussed along with suggestions for future research.
Evaluation and Comparison of the Processes in the Frozen Vegetable Production Using Machine Learning Methods

In the paper, the study of the carbon footprint (CF) assessment in the frozen vegetable production processes is shown in order to receive low-carbon products. Three methods of clusterization have been chosen for the production assessment. The results of clusterization are evaluated by five classification methods: k-Nearest Neighbors, Multilayer Perceptron, C4.5, Random Forrest and Support Vector Machines with a radial basis kernel function. In the chosen model with five clusters, the best clusterization methods are k-means followed by Canopy.
The principles and applications of XTR115 current loop circuit

Aiming at the needs of data acquisition and anti-electromagnetic interference environment in monitoring,this paper introduced a low-power two-wire 4~20mA current loop circuit based on XTR115,firstly,it discussed the performance characteristic and working principles of XTR115,secondly,according to the typical applications in temperature sensor,it described the design processes of the internal current loop circuit and typical application circuit in detail.Actual measurement results show the current loop circuit based on XTR115 has great capacity of resisting disturbance,exact data transmission.It has wide application prospect in industry measurement.
A Metataxonomic Analysis of Maple Sap Microbial Communities Reveals New Insights Into Maple Syrup Complexity

Maple syrup, an emblematic food product of Canada is produced from the concentration of sap collected from maple trees during spring. During this season, the trees come out of dormancy, which modifies sap composition. Meanwhile, microorganisms that contaminate sap as it is collected can also modify its composition. As these two factors can impact the quality of maple syrup, we aimed to better understand how microbial communities vary along dormancy release. We estimated the absolute abundance of bacteria and fungi in maple sap along a dormancy release index using high-throughput amplicon sequencing and digital droplet PCR (ddPCR). Several members were identified as indicators of maple sap composition, syrup organoleptic conformity and color, some of which are also hubs in the microbial association networks. We further explored bacterial communities by performing a predictive functional analysis, revealing various metabolic pathways correlated to dormancy release. Finally, we performed an experimental investigation of maple sap carrying capacity and limiting nutrients along dormancy release and found that maple sap composition variation influences its carrying capacity. Taken together, our results indicate that an increase in nitrogen supply in the form of allantoate combined with possible metabolite excretion could lead microbial communities towards different paths. Indeed, we observed a greater heterogeneity during late dormancy release which in turn could explain the variation in maple syrup quality. Further experimental investigation into the contribution of microbial, vegetal, environmental, technological, and processing factors to the final composition of maple syrup will be required to improve our understanding of this complex and flavorful food matrix and to develop quality control strategies.
Variation of Soil Microbial Community and Sterilization to Fusarium oxysporum f. sp. niveum Play Roles in Slightly Acidic Electrolyzed Water-Alleviated Watermelon Continuous Cropping Obstacle

It is critical to exploit technologies for alleviating watermelon continuous cropping obstacle which frequently occurs and results in the limiting production and economic losses of watermelon. This study aimed to explore the effects of slightly acidic electrolyzed water (SAEW) on watermelon continuous cropping obstacles. The results showed that SAEW significantly improved the growth of watermelon seedlings cultivated in continuous cropping soil and caused a mass of changes to the diversity of the soil microbial community. Compared with Con, SAEW decreased the diversity index of bacteria by 2%, 0.48%, and 3.16%, while it increased the diversity index of fungus by 5.68%, 10.78%, and 7.54% in Shannon, Chao1, and ACE index, respectively. Besides, the enrichment level of Fusarium oxysporum f. sp. niveum (FON) was remarkably downregulated by 50.2% at 14 days of SAEW treatment, which could decrease the incidence of Fusarium wilt disease. The wet and dry weights of FON mycelia in the fluid medium were depressed more than 93%, and the number of FON colonies in continuous cropping soil was reduced by 83.56% with SAEW treatment. Additionally, a strong correlation between watermelon, FON, and SAEW was presented by correlation analysis. Furthermore, the content of endogenous reactive oxygen species (ROS) was over quadruply increased by SAEW, which may contribute to the sterilizing effect of SAEW on FON. Taken together, our findings demonstrated that exogenous SAEW could alter the soil microbial diversity and decrease the accumulation of FON, which improved the growth of watermelon seedlings and finally alleviated continuous cropping obstacles of watermelon.
Designing instruction for active and reflective learners in the flipped classroom

Purpose – This paper proposes a framework of instructional strategies that would facilitate active and reflective learning processes in the flipped classroom It is aimed at allowing one’s maximum potential to be reached regardless of any individual learning style.As tertiary classrooms increasingly needs to be as active and social as possible, the needs of the more introverted student could have been unintentionally overlooked.Therefore, the objective of this study was to produce an instructional design that could accommodate different learning styles and preferences in the flipped classroom.Method – A design-based research approach was employed in three phases (preliminary research, prototyping phase and assessment phase) in a flipped communication studies course of 24 students.The instructional design, based on a literature review on the flipped classroom and Felder and Silverman’s active-reflective learning style dimensions, was tested and refined over six iterative design cycles to produce a final design framework.Findings – Qualitative findings via observation showed that despite a learning curve, the finalized instructional design was able to facilitate different learning styles satisfactorily.Added benefits included learner empowerment, engagement, motivation and improved communication and thinking skills.Significance – As a design-based research, this study may be significant from the perspectives of both educational research and practice.Besides adding to the existent literature on different implementations of the flipped classroom, the proposed instructional design may serve as a practical guide for instructors who wish to flip their classrooms and spend face-to-face class time with their students on a more meaningful and personalized level.
Microglia-Dependent and Independent Brain Cytoprotective Effects of Mycophenolate Mofetil During Neuronal Damage

Acute lesions of the central nervous system often lead to permanent limiting deficits. In addition to the initial primary damage, accompanying neuroinflammation is responsible for progression of damage. Mycophenolate mofetil (MMF) as a selective inhibitor of inosine 5-monophosphate dehydrogenase (IMPDH) was shown to modulate the inflammatory response and promote neuronal survival when applied in specific time windows after neuronal injury. The application of brain cytoprotective therapeutics early after neuronal damage is a fundamental requirement for a successful immunomodulation approach. This study was designed to evaluate whether MMF can still mediate brain cytoprotection when applied in predefined short time intervals following CNS injury. Furthermore, the role of microglia and changes in IMPDH2 protein expression were assessed. Organotypic hippocampal slice cultures (OHSC) were used as an in vitro model and excitotoxically lesioned with N-methyl-aspartate (NMDA). Clodronate (Clo) was used to deplete microglia and analyze MMF mediated microglia independent effects. The temporal expression of IMPDH2 was studied in primary glial cell cultures treated with lipopolysaccharide (LPS). In excitotoxically lesioned OHSC a significant brain cytoprotective effect was observed between 8 and 36 h but not within 8 and 24 h after the NMDA damage. MMF mediated effects were mainly microglia dependent at 24, 36, 48 h after injury. However, further targets like astrocytes seem to be involved in protective effects 72 h post-injury. IMPDH2 expression was detected in primary microglia and astrocyte cell cultures. Our data indicate that MMF treatment in OHSC should still be started no later than 8–12 h after injury and should continue at least until 36 h post-injury. Microglia seem to be an essential mediator of the observed brain cytoprotective effects. However, a microglia-independent effect was also found, indicating involvement of astrocytes.
Cerebral Metabolic Network in Patients With Anti-N-Methyl-D-Aspartate Receptor Encephalitis on 18F-FDG PET Imaging

Background Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common autoimmune encephalitis (AE), and the prognosis may significantly be improved if identified earlier and immune-related treated more effectively. This study evaluated the brain metabolic network using fluorodeoxyglucose positron emission tomography (FDG PET). Material and methods FDG PET imaging of patients with NMDAR encephalitis was used to investigate the metabolic connectivity network, which was analyzed using the graph theory. The results in patients were compared to those in age- and sex-matched healthy controls. Results The hub nodes were mainly in the right frontal lobe in patients with NMDAR encephalitis. The global and local efficiencies in most brain regions were significantly reduced, and the shortest characteristic path length was significantly longer, especially in the temporal and occipital lobes. Significant network functions of topology properties were enhanced in the right frontal, caudate nucleus, and cingulate gyrus. In addition, the internal connection integration in the left cerebral hemisphere was poor, and the transmission efficiency of Internet information was low. Conclusion The present findings indicate that those characteristic and connections of metabolic network were changed in the brain by graph theory analysis quantitatively, which is helpful to better understand neuropathological and physiological mechanisms in patients with anti-NMDAR encephalitis.
Efficacy and Safety of Electro-Thumbtack Needle Therapy for Patients With Chronic Neck Pain: Protocol for a Randomized, Sham-Controlled Trial

Background Chronic neck pain is a prevalent condition adversely impacting patients' wellbeing in both life and work experience. Electro-thumbtack needle (ETN) therapy, combining acupuncture with transcutaneous stimulation, might be one of the effective complementary and alternative medicine (CAM) therapies in treating chronic neck pain, although the evidence is scarce. This study aims to estimate the efficacy and safety of ETN therapy for chronic neck pain. Methods and Analysis This is a sham-controlled, randomized clinical trial. A total of 180 subjects will be randomly allocated to either the ETN group or the sham ETN group. Treatment will be administrated three times a week for four consecutive weeks, with a 6-month follow-up. The primary outcome measure will be the Numerical Rating Scale for neck pain (NRS-NP) over a period of the 4 weeks. Secondary outcome measures include the Northwick Park Neck Pain Questionnaire (NPQ), Neck Disability Index (NDI), Patient Global Impression of Change (PGIC), patient expectation, and preference assessment. The chi-square test or Fisher's exact test will be used for proportions of participants having clinically meaningful improvement. Analysis of covariance or repeated-measures analysis of variance will be applied to examine changes in the outcome measures from baseline. Discussions This prospective trial will contribute to evaluating the efficacy and safety of ETN in the treatment of chronic neck pain, with an intermediate-term follow-up. This study will provide further evidence for clinical neck pain management. Ethics and Dissemination This trial has been approved by the Research Ethical Committee of Guang'anmen Hospital (ethical approval number: 2021-039-KY-01). Recruitment began in March 2022 and will continue until December 2023. Dissemination plans include posters, WeChat, websites, and bulletin boards in hospital and communities. Clinical Trial Registration This trial is registered at ClinicalTrials.gov (identifier: NCT04981171).
How Leisure Involvement Affects Repurchase Intention in Fitness Clubs? The Mediating Role of Commercial Friendship

This study explores the relationships among leisure involvement, business or commercial friendship, satisfaction, and willingness to repurchase in customers' use of customized fitness services. This study randomly sampled and analyzed the customers of fitness clubs (N = 234) in China. The results showed that leisure involvement had a positive impact on repurchase intention and satisfaction. Moreover, the mediating effect of commercial friendship was found in the relationship between leisure involvement, repurchase intention, and satisfaction. Overall, the study contributes to the literature by exploring the interaction effects of different types of consumer leisure involvement and commercial friendships in customized fitness services models on satisfaction and repurchase intentions'.
Predicting Risk Propensity Through Player Behavior in DOTA 2: A Cross-Sectional Study

As traditional methods such as questionnaires for measuring risk propensity are not applicable in some scenarios, a nonintrusive method that could automatically identify individuals' risk propensity could be valuable. This study utilized Defense of the Ancients 2 (DOTA 2) single match data and historical statistics to train predictive models to identify risk propensity by machine learning methods. Self-reported risk propensity scores from 218 DOTA 2 players were paired with their behavioral metrics. The best-performing model occurred with Gaussian process regression. The root mean square error of this model was 1.10, the correlation between predicted scores and self-reported questionnaire scores was 0.44, the R-squared was 0.17, and the test–retest reliability was 0.67. We discussed how selected behavioral features could contribute to predicting risk propensity and how the approach could be of potential value in the application of perceiving individuals' risk propensities. Moreover, the limitations of our study were discussed, and recommendations were made for future studies in this field.
Ovarian Response, Pregnancy Outcomes, and Complications Between Salpingectomy and Proximal Tubal Occlusion in Hydrosalpinx Patients Before in vitro Fertilization: A Meta-Analysis

Objectives Contradictory findings exist in studies comparing salpingectomy and proximal tubal occlusion (PTO) in treating hydrosalpinx patients before in vitro fertilization (IVF). Therefore, this meta-analysis aimed to comprehensively compare ovarian response, pregnancy outcomes, and complications between salpingectomy and PTO in treating these patients. Methods Embase, PubMed, and Web of Science were searched to identify relevant articles published from 1980 to August 31, 2020. Eight studies that involve 716 hydrosalpinx patients before IVF were included, among whom 408 patients received salpingectomy and 308 patients received PTO. The data were pooled; the standardized mean difference (SMD) or odds ratio (OR) was calculated. Results Proximal tubal occlusion-treated patients had higher fertilization rate (SMD = 0.35, 95% CI: 0.11–0.59), while similar days of controlled ovarian hyperstimulation (COH) (SMD: 0.15, 95% CI: −0.36–0.67) and number of retrieved oocytes (SMD = −0.22, 95% CI: −0.54–0.10) compared with salpingectomy-treated patients. Furthermore, no difference of implantation rate (OR = 1.17, 95% CI: 0.62–2.20), clinical pregnancy rate (OR = 0.82, 95% CI: 0.59–1.15), ongoing pregnancy rate (OR = 0.64, 95% CI: 0.36–1.13), or live birth rate (OR = 0.67, 95% CI: 0.16–2.72) was shown between salpingectomy-treated patients and PTO-treated patients. Additionally, ectopic pregnancy rate (OR = 1.13, 95% CI: 0.21–5.92) and miscarriage rate (OR = 0.88, 95% CI: 0.31–2.48) were similar between salpingectomy-treated patients and PTO-treated patients. Conclusion Proximal tubal occlusion exhibits a higher fertilization rate but no obvious benefits on days of COH, number of retrieved oocytes, pregnancy outcomes, and complications over salpingectomy in hydrosalpinx patients before IVF.
To Be Ethical and Responsible Digital Citizens or Not: A Linguistic Analysis of Cyberbullying on Social Media

As a worldwide epidemic in the digital age, cyberbullying is a pertinent but understudied concern—especially from the perspective of language. Elucidating the linguistic features of cyberbullying is critical both to preventing it and to cultivating ethical and responsible digital citizens. In this study, a mixed-method approach integrating lexical feature analysis, sentiment polarity analysis, and semantic network analysis was adopted to develop a deeper understanding of cyberbullying language. Five cyberbullying cases on Chinese social media were analyzed to uncover explicit and implicit linguistic features. Results indicated that cyberbullying comments had significantly different linguistic profiles than non-bullying comments and that explicit and implicit bullying were distinct. The content of cases further suggested that cyberbullying language varied in the use of words, types of cyberbullying, and sentiment polarity. These findings offer useful insight for designing automatic cyberbullying detection tools for Chinese social networking platforms. Implications also offer guidance for regulating cyberbullying and fostering ethical and responsible digital citizens.