Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring Values Orientation to build Green Loyalty: the Role of Egoistic, Supply Chain Management, and Biospheric

Abstra ct- The purpose of this paper is to explore the impact of eight dimensions of green supply chain management (GSCM) on economic, environmental and social performance, which are the three dimensions of corporate sustainability. This study aims to examine and analyze the influence of values orientation which consists of e goistic, supply chain , and biospheric towards green loyalty. This research is empirical research through questionnaire survey method distributed to 402 consumers who have experience buying green brands in Indonesia . With SEM data analysis tool . T he results show that ego i sitic and supply chain have a positive effect on green loyalty, while altruistic does not affect green loyalty.
Baicalin suppresses lung cancer growth by targeting PDZ-binding kinase/T-LAK cell-originated protein kinase

Baicalin is the main bioactive component extracted from the traditional Chinese medicine Baical Skullcap Root, and its anti-tumor activity has been studied in previous studies. PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK), a serine/threonine protein kinase, is highly expressed in many cancer cells and stimulates the tumorigenic properties, and so, it is a pivotal target for agent to cure cancers. We reported for the first time that baicalin suppressed PBK/TOPK activities by directly binding with PBK/TOPK in vitro and in vivo. Ex vivo studies showed that baicalin suppressed PBK/TOPK activity in JB6 Cl41 cells and H441 lung cancer cells. Moreover, knockdown of PBK/TOPK in H441 cells decreased their sensitivity to baicalin. In vivo study indicated that injection of baicalin in H441 tumor-bearing mice effectively suppressed cancer growth. The PBK/TOPK downstream signaling molecules Histone H3 and ERK2 in tumor tissues were also decreased after baicalin treatment. Taken together, baicalin can inhibit proliferation of lung cancer cells as a PBK/TOPK inhibitor both in vitro and in vivo.
A PREDICTION MODEL FOR AUTOMOBILE SALES IN TURKEY USING DEEP NEURAL NETWORKS

Demand prediction in the supply chain process, which is the driving force in all decisions, is one of the most important components of the supply chain process. Prediction of future goods and services is the starting point of all other predictions and provides the basic entry to all other functions. In this study, an 8-layer Deep Neural Network model was recommended for vehicle sales prediction. The inputs of the model consist of features, such as exchange rate, the gross domestic product, consumer confidence index, and the consumer price index. The vehicle sales forecast was made according to the output of the model. We analyzed a total of 90 data on a monthly basis between the years of 2011 and 2018 was collected.
Responses to copper stress in the metal‐resistant bacterium Cupriavidus gilardii CR3: a whole‐transcriptome analysis

Microbial metal‐resistance mechanisms are the basis for the application of microorganisms in metal bioremediation. Despite the available studies of bacterial molecular mechanisms to resistance metals ions (particularly copper), the understanding of bacterial metal resistance is very limited from the transcriptome perspective. Here, responses of the transcriptome (RNA‐Seq) was investigated in Cupriavidus gilardii CR3 exposed to 0.5 mM copper, because strain CR3 had a bioremoval capacity of 38.5% for 0.5 mM copper. More than 24 million clean reads were obtained from six libraries and were aligned against the C. gilardii CR3 genome. A total of 310 genes in strain CR3 were significantly differentially expressed under copper stress. Apart from the routine copper resistance operons cus and cop known in previous studies, Gene ontology and Kyoto Encyclopedia of Genes and Genomes analyses of differentially expressed genes indicated that the adenosine triphosphate‐binding cassette transporter, amino acid metabolism, and negative chemotaxis collectively contribute to the copper‐resistant process. More interestingly, we found that the genes associated with the type III secretion system were induced under copper stress. No such results were reordered in bacteria to date. Overall, this comprehensive network of copper responses is useful for further studies of the molecular mechanisms underlying responses to copper stress in bacteria.
IEEE 802.11ah Network Planning for IoT Smart Meter Application: Case Study in Bandung Area

The growth of Wireless Fidelity (WiFi) technology is so rapid and popular. The technology most widely used for WiFi services is the IEEE 802.11 family of standards. To support the Internet of Things (IoT) era, 802.11ah standard technology has developed, and the standard is intended to provide a low-cost mode of operation, with a wider coverage area, and can support thousands of devices per cell. This paper discusses IEEE 802.11ah Standard Network Planning for the Internet of Things Application (Case Study: Smart Meter Using WiFi.id Network in Bandung), to improve network quality in terms of coverage and capacity to improve the efficiency of the WiFi network and so that it can supports the Internet of Things (IoT) service. Network planning using 802.11ah for the internet of things application with a smart meter case study using the WiFi.id network has been successfully carried out. To cover the entire area of Bandung, 23 sites are required. In the capacity, the Tx slots needed to cover possible smart meters for each site are only 9 tx slots out of a total of 100 tx slots.
Energy Storage Overflow-Aware Data Delivery Scheme for Energy Harvesting Wireless Sensor Networks

In Energy-Harvesting Wireless Sensor Networks (EH-WSNs), energy storage with limited capacity is used in the nodes to store the harvested energy. Energy storage overflow (ESO) happens when the energy storage is full, which causes the nodes to be unable to store the newly harvested energy. In traditional data delivery schemes, there is the problem of “energy hungry and surplus coexistence”, meaning that some nodes in the network are hungry for energy while some other nodes continue to waste energy due to ESO. To alleviate this problem, in this paper, we present the ESO-aware multiple path (EAMP) data delivery scheme so that more data can be delivered to the sink. With the EAMP, multiple disjoint paths from the source node to the sink are constructed, and the source node splits data into multiple pieces with each going through one of the paths, which helps in mitigating ESO. Simulation results show that the proposed EAMP scheme can deliver more data than the existing ones.
Development and Validation of a Deep Learning–Based Automated Detection Algorithm for Major Thoracic Diseases on Chest Radiographs

Key Points Question Can a deep learning–based algorithm accurately discriminate abnormal chest radiograph results showing major thoracic diseases from normal chest radiograph results? Findings In this diagnostic study of 54 221 chest radiographs with normal findings and 35 613 with abnormal findings, the deep learning–based algorithm for discrimination of chest radiographs with pulmonary malignant neoplasms, active tuberculosis, pneumonia, or pneumothorax demonstrated excellent and consistent performance throughout 5 independent data sets. The algorithm outperformed physicians, including radiologists, and enhanced physician performance when used as a second reader. Meaning A deep learning–based algorithm may help improve diagnostic accuracy in reading chest radiographs and assist in prioritizing chest radiographs, thereby increasing workflow efficacy.
As experimentações corporais nos processos formativos da graduação em terapia ocupacional: uma revisão na literatura brasileira

Introducao: A nocao de corpo se constituiu socialmente, ao longo da historia, alterando profundamente a relacao dos individuos com o seu proprio corpo. Ao pautar-se em concepcoes de corpo para alem do corpo biologico, o uso de experimentacoes corporais durante a formacao graduada de terapia ocupacional tem sido um recurso relevante no desenvolvimento de habilidades pessoais para a pratica profissional. Objetivo: Identificar e sintetizar o conhecimento disponivel sobre a relacao entre o uso de experimentacoes corporais e a formacao graduada de terapeutas ocupacionais. Metodo: A metodologia utilizada foi a revisao integrativa da literatura. Foi realizado um teste de sensibilidade para definicao das palavras-chave e das fontes de dados. As buscas foram realizadas nos periodicos nacionais de terapia ocupacional, na SciELO e na base de dado LILACS. Para selecao da amostra foram realizadas tres etapas. Foram aplicados criterios de inclusao/exclusao, resultando na amostra final de oito artigos. Resultados: Os resultados deste estudo mostram esforcos de mudancas na formacao de profissionais da terapia ocupacional, visando a romper com os modelos tradicionais de ensino ao considerar as experimentacoes corporais como recursos que permitem o compartilhamento de experiencias. Conclusao: Os autores defendem uma formacao que invista em novos cenarios de aprendizagem, buscando formar profissionais mais atentos e abertos as necessidades do outro. Entretanto, ainda sao necessarios estudos que identifiquem de que forma os profissionais que vivenciaram as experimentacoes corporais na formacao conduzem sua pratica e sua relacao com o cliente.
Emergence of optrA-mediated linezolid resistance in enterococci from France, 2006-16.

OBJECTIVES To describe the epidemiological trend of linezolid-resistant enterococci (LRE) collected in France from 2006 to 2016 and to extensively characterize LRE isolates. METHODS The National Reference Center for Enterococci (NRC-Enc) received enterococcal isolates suspected to be VRE and/or LRE from all French hospitals between 2006 and 2016. LRE isolates were phenotypically characterized and their genomes were entirely sequenced by Miseq (Illumina). Transfer of linezolid resistance was attempted by filter mating experiments. RESULTS Out of 3974 clinical isolates of enterococci received at the NRC-Enc over the period, 9 (0.2%) were LRE (MICs 8 to >32 mg/L), including 6 Enterococcus faecium and 3 Enterococcus faecalis. This overall prevalence significantly increased over the study period, reaching 0.8% in 2016. The five LRE isolated before 2016 were vanA-positive E. faecium whereas strains isolated in 2016 (one E. faecium and three E. faecalis) were susceptible to vancomycin. None of these isolates was part of an outbreak, while E. faecium strains were assigned to four different STs [17 (1), 80 (3), 412 (1) and 650 (1)] and all three E. faecalis belonged to ST480. Except for the strain isolated in 2010, all LRE were positive for optrA, which was located on plasmids (5/8) or in the chromosome (3/8). Plasmid transfer of optrA was successful in three cases. CONCLUSIONS There has been a significant increase in the prevalence of LRE in France over time; this is due to the spread of optrA among E. faecium and E. faecalis human clinical isolates (VRE or not).
Symmetrical Modification of Minimized Dermaseptins to Extend the Spectrum of Antimicrobials with Endotoxin Neutralization Potency

Antimicrobial peptides (AMPs) have emerged as a promising class of antimicrobial agents that could potentially address the global antibiotic resistance. Generating mirror-like peptides by minimizing dermaseptin family sequences is an effective strategy for designing AMPs. However, the previous research still had some limitations such as lower effectiveness and a narrow spectrum of antibacterial activity. To further expand and hone this strategy, we designed a series of AMPs consisting of the WXMXW-NH2 motif (X represents V, I, F, and W; M represents KAAAKAAAK). The peptides formed α-helices and displayed broad-spectrum antimicrobial activities against eleven types of clinical bacteria including both Gram-negative and Gram-positive bacteria. The optimized peptide WW exhibited high physical rupture by inducing membrane shrinkage, disruption, and lysis. Moreover, WW effectively neutralized endotoxins and inhibited the inflammatory response while having the highest therapeutic index. In conclusion, these results indicated that the peptide WW has potential as a broad-spectrum antimicrobial agent or preservative for overcoming the risk of multidrug resistance in localized or external therapeutic applications.
Gold-capped mesoporous silica nanoparticles as an excellent enzyme-responsive nanocarrier for controlled doxorubicin delivery

Abstract Mesoporous silica nanoparticles (MSNs) have ideal characteristics as next generation of controlled drug delivery systems. In this study, a MSN-based nanocarrier was fabricated and gold nanoparticle (GNP)-biotin conjugates were successfully grafted onto the pore outlets of the prepared MSN. This bioconjugate served as a capping agent with a peptide-cleavable linker sensitive to matrix metalloproteinases (MMPs), which are overexpressed extracellular proteolytic enzymes in cancerous tissue. The prepared nanocarriers were fully characterised by scanning electron microscopy (SEM), transmission electron microscopy (TEM), nitrogen adsorption/desorption, Fourier transform infra-red spectroscopy (FTIR), dynamic light scattering (DLS) and thermo gravimetric analysis (TGA). In vitro release studies showed efficient capping of MSNs with gold gate and controlled release of Doxorubicin (DOX) in the presence of matrix metalloproteinase-2 (MMP-2) and acidic pH values. High DOX-loading capacity (21%) and encapsulation efficiency (95.5%) were achieved using fluorescence technique. DOX-loaded nanocarriers showed high cytocompatibility and could efficiently induce cell death and apoptosis in the MMP-2 overexpressed cell lines. Moreover, Haemolysis, platelet activation and inflammatory responses assessment approved excellent hemocompatibility and minimal side effects by encapsulation of DOX in MSNs carrier.
Common Audiological Functional Parameters (CAFPAs): statistical and compact representation of rehabilitative audiological classification based on expert knowledge

Abstract Objective: As a step towards objectifying audiological rehabilitation and providing comparability between different test batteries and clinics, the Common Audiological Functional Parameters (CAFPAs) were introduced as a common and abstract representation of audiological knowledge obtained from diagnostic tests. Design: Relationships between CAFPAs as an intermediate representation between diagnostic tests and audiological findings, diagnoses and treatment recommendations (summarised as “diagnostic cases”) were established by means of an expert survey. Expert knowledge was collected for 14 given categories covering different diagnostic cases. For each case, the experts were asked to indicate expected ranges of diagnostic test outcomes, as well as traffic light-encoded CAFPAs. Study sample: Eleven German experts in the field of audiological rehabilitation from Hanover and Oldenburg participated in the survey. Results: Audiological findings or treatment recommendations could be distinguished by a statistical model derived from the experts' answers for CAFPAs as well as audiological tests. Conclusions: The CAFPAs serve as an abstract, comprehensive representation of audiological knowledge. If more detailed information on certain functional aspects of the auditory system is required, the CAFPAs indicate which information is missing. The statistical graphical representations for CAFPAs and audiological tests are suitable for audiological teaching material; they are universally applicable for real clinical databases.
Impact of nanoencapsulated natural bioactive phenolic metabolites on chitosan nanoparticles as aflatoxins inhibitor

Aflatoxins are part of fungal secondary metabolites which become serious health, environmental, and economic problems and can cause corruption of many crops and agricultural grains that used as food and feed for human and animal. Aflatoxins mainly produce by Aspergillus spp. especially Aspergillus flavus and Aspergillus parasiticus. The present work aimed to study the effect of nanoencapsulation of chitosan (CS) nanoparticles with two phenolic compounds 1‐(2‐ethyl,6‐heptyl)phenol (EHP) extracted from Cuminum cyminum and 5‐ethyl‐2‐(methoxymethyl)phenol (EMMP) extracted from black pepper on growth and aflatoxins production of A. flavus and A. parasiticus. A. flavus growth was completely inhibited by 0.6 mg/ml of EHP and EMMP as well as A. parasiticus which showed the same minimal inhibition concentration with the first compound and 0.8 mg/ml with the second one. CS nanoparticles inhibited the growth of the tested organisms more than CS especially with A. parasiticus and this potency became much better when nanoencapsulated with the two extracted phenolic compounds. In inhibition of aflatoxins production, EHP reduced the production of aflatoxin B1 and B2 of A. flavus by 68.6% and 69.7%, respectively. In the same manner EMMP reduce the production of the two toxins by 87.3% and 82.6%, respectively. The reduction effect of CS nanoparticles is much more than that of CS as it record in most cases about twofold increase. Nanoencapsulation of CS nanoparticles by the extracted phenolic compounds is much more effective with complete inhibition of aflatoxin B1 of both fungi and aflatoxin G1 of A. parasiticus.
Predicting Stock Markets with Commodities - An Empirical Study on the Nordic Market

This study examines if commodity indices can be used to predict stock index returns on the Nordic financial markets. With a forecast period between 2000 and 2016, the study is conducted with an Ordinary Least Squares method to predict both in-sample and out-of- sample. The results indicate that the Baltic Dry Index and the London Metal Exchange Index are the best predictors of monthly stock returns for in-sample predictability. When testing for state-switching abilities of the commodity variables, we observe that predictability is only found in recessions and disappears in expansions. We also find evidence pointing in the direction of increasing commodity prices being better news in recessions than in expansions. Our estimates perform poorly out-of-sample, indicating that the information possessed by our predictions is of little use for an investor seeking profitable investment opportunities. The portfolios based on the significance of our estimators fail to outperform their respective benchmark index in 25 out of 28 cases. (Less)
EFEKTIVITAS PEMBELAJARAN KEWIRAUSAHAAN

The study was conducted with the aim of finding out whether there were differences in attitudes, motivation, and entrepreneurial interests of STIE IPWIJA students before and after receiving entrepreneurship learning. The research was conducted at the STIE IPWIJA Campus in 2019. The research method used was a comparative study with the Quasi Experiment (One Group Pretest and Postest Design) design. The population in this study were students who were taking Entrepreneurship courses totally of 225 students. The research sample used was 150 students taken by the Cluster Random Sampling technique. Research data were collected through a closed questionnaire given to students before and after taking entrepreneurship courses. The research data were processed by descriptive and inferential analysis using the correlated test formula (t-test) of two samples. Data processing using SPSS software. The results showed that: (1) There were differences in entrepreneurship attitudes of STIE IPWIJA students before and after receiving entrepreneurship course, (2) There were differences in entrepreneurship motivation of STIE IPWIJA students before and after receiving entrepreneurship course, (3) There were no differences in entrepreneurial interest in STIE IPWIJA students before and after receiving entrepreneurship course. Keywords: Effectiveness, Entrepreneurship Learning, Motivation, Attitudes, and Entrepreneurial Interest. ABSTRAK Penelitian dilaksanakan dengan tujuan untuk mengetahui apakah ada perbedaan sikap, motivasi dan minat berwirausaha mahasiswa STIE IPWIJA sebelum dan sesudah mendapat pembelajaran kewirausahaan. Penelitian dilaksanakan di Kampus STIE IPWIJA Tahun 2019. Metode penelitian yang digunakan adalah studi komparatif dengan desain Quasi Experiment (One Group Pretest and Postest Design). Populasi dalam penelitian adalah mahasiswa yang sedang menempuh mata kuliah Kewirausahaan berjumlah 225. Sampel penelitian yang digunakan sebanyak 150 mahasiswa yang diambil dengan teknik Cluster Random Sampling. Data penelitian dikumpulkan melalui kuesioner tertutup yang diberikan kepada mahasiswa sebelum dan sesudah menempuh mata kuliah kewirausahaan. Data penelitian diolah dengan analisis deskriptif dan inferensial menggunakan rumus uji beda (t-test) dua sampel yang berkorelasi. Pengolahan data menggunakan bantuan software SPSS. Hasil penelitian menunjukkan bahwa: (1) Ada perbedaan sikap berwirausaha mahasiswa STIE IPWIJA sebelum dan sesudah mendapatkan pembelajaran kewirausahaan, (2) Ada perbedaan motivasi berwirausaha mahasiswa STIE IPWIJA sebelum dan sesudah mendapatkan pembelajaran kewirausahaan, (3) Tidak ada perbedaan minat berwirausaha mahasiswa STIE IPWIJA sebelum dan sesudah mendapatkan pembelajaran kewirausahaan. Kata kunci: Efektivitas, Pembelajaran Kewirausahaan, Motivasi, Sikap, dan Minat Berwirausaha.
gkm 228 3 dLOGO : a web server for the identification , analysis and use of conserved protein substructures

3dLOGO is a web server for the identification and analysis of conserved protein 3D substructures. Given a set of residues in a PDB (Protein Data Bank) chain, the server detects the matching substructure(s) in a set of user-provided protein structures, generates a multiple structure alignment centered on the input substructures and highlights other residues whose structural conservation becomes evident after the defined superposition. Conserved residues are proposed to the user for highlighting functional areas, deriving refined structural motifs or building sequence patterns. Residue structural conservation can be visualized through an expressly designed Java application, 3dProLogo, which is a 3D implementation of a sequence logo. The 3dLOGO server, with related documentation, is available at http://3dlogo.uniroma2. it/
UvA-DARE ( Digital Academic Repository ) Aerobic degradation of polychlorinated biphenyls by Alcaligenes sp . JB 1 : metabolites and enzymes

In contrast to the degradation of pentaand hexachlorobiphenyls in chemostat cultures, the metabolism of PCBs by Alcaligenes sp. JB1 was shown to be restricted to PCBs with up to four chlorine substituents in resting-cell assays. Among these, the PCB congeners containing ortho chlorine substituents on both phenyl rings were found to be least degraded. Monochloro-benzoates and dichlorobenzoates were detected as metabolites. Resting cell assays with chlorobenzoates showed that JB1 could metabolize all three monochlorobenzoates and dichlorobenzoates containing only meta and para chlorine substituents, but not dichlorobenzoates possessing an ortho chlorine substituent. In enzyme activity assays, meta cleaving 2,3-dihydroxybiphenyl 1,2-dioxygenase and catechol 2,3-dioxygenase activities were constitutive, whereas benzoate dioxygenase and ortho cleaving catechol 1,2-dioxygenase activities were induced by their substrates. No activity was found for pyrocatechase II, the enzyme that is specific for chlorocatechots. The data suggest that complete mineralization of PCBs with three or more chlorine substituents byAlcaligenes sp. JB1 is unlikely. Abbreviations: PCB polychlorinated biphenyls, CBA chlorobenzoate, D di-, Tr tri-, Te tetra-, Pe penta-, H hexa