Miracle-dz/UniFAR-FTUs huggingface dataset:
Developing a Brief Suicide Prevention Intervention and Mobile Phone Application: A Qualitative Report

Suicide is the second leading cause of death among youth and has become a serious public health problem. There has been limited research on strategies to decrease the likelihood of reattempt in adolescents. As phase one of a treatment development study, clinicians, parents, and adolescents participated in qualitative interviews in order to gain new perspectives on developing a targeted intervention and a safety plan phone application for suicide prevention. Participants indicated that transition of care, specific treatment targets, and safety planning were important parts of treatment. In addition, all participants endorsed the use of a smartphone application for these purposes.
Early risk of recurrent stroke in patients with symptomatic carotid near-occlusion: Results from CAOS, a multicenter registry study

Background The risk of recurrent stroke among patients with symptomatic carotid near-occlusion is not well established, and management of the condition remains controversial. Symptomatic carotid near-occlusion with full collapse has been identified as a strong predictor of early recurrence. We aimed to analyze the 90-day risk of recurrent ipsilateral ischemic stroke in medically treated patients with symptomatic carotid near-occlusion. Methods We performed a multicenter, nationwide, prospective study from January 2010 to May 2016. Patients with angiography-confirmed symptomatic carotid near-occlusion were included. The primary endpoint was ipsilateral ischemic stroke or transient ischemic attack (TIA) within 90 days after the presenting event. For this analysis, patients who underwent revascularization within 90 days after stroke were excluded. Results The study population comprised 141 patients from 17 Spanish centers; 83 patients were treated medically. Primary endpoint occurred in eight patients, resulting in a cumulative rate of 10.6% (95% CI, 3.7–17.5). Previous history of stroke or transient ischemic attack was identified as an independent predictor for recurrence in the multivariate Cox regression analysis (HR, 4.37 [95% CI, 1.05–18.18]; p = 0.043), while the presence of full collapse was not associated with an increased risk (HR, 0.81 [95% CI, 0.17–3.92]; p = 0.793). The risk of recurrence was also not affected by the presence of significant stenosis or occlusion of the contralateral carotid artery, or by the collateral circulation. Conclusions Patients with symptomatic carotid near-occlusion seem to have an increased risk of early ipsilateral recurrent stroke. Our results contrast with the low risk of symptomatic carotid near-occlusion reported to date. Full collapse did not increase the risk of recurrent stroke in our study.
Serum Vascular Endothelial Growth Factor Levels Lack Predictive Value in Patients with Active Ankylosing Spondylitis Treated with Golimumab

Objective. To assess vascular endothelial growth factor (VEGF) correlations with new bone formation and bone marrow edema in patients with ankylosing spondylitis (AS) treated with golimumab (GOL). Methods. Following placebo control (through weeks 16 and 24), GO-RAISE (A Multicenter Randomized, Double-blind, Placebo-controlled Trial of Golimumab, a Fully Human Anti-TNF-α Monoclonal Antibody, Administered Subcutaneously, in Subjects with Active Ankylosing Spondylitis; ClinicalTrials.gov: NCT00265083) all patients received GOL; sera/images were available at weeks 0, 104, and 208. Lateral spinal radiographs and magnetic resonance imaging (MRI) were scored using the modified Stokes Ankylosing Spondylitis Spine Score (mSASSS) and the Ankylosing Spondylitis Spinal MRI activity score, respectively. Results. VEGF levels and the mSASSS did not significantly correlate. Logistic regression analyses showed no association between VEGF levels and an increased risk of syndesmophyte formation at weeks 104 and 208. Pretreatment/Week 14 VEGF did not predict MRI scores/changes at Week 104. Conclusion. Serum VEGF did not predict radiographic progression/spinal inflammation in patients receiving antitumor necrosis factor.
Sequence-Based Diagnosis of Tyrosinase-Related Oculocutaneous Albinism: Successful Sequence Analysis of the Tyrosinase Gene from Blood Spots Dried on Filter Paper

Background: A large number of mutations of the tyrosinase gene result in oculocutaneous albinism (OCA). Therefore, at present, sequence analysis of the tyrosinase gene has become necessary to diagnose OCA patients and their relatives. Objective: The aim of this study was to facilitate the sequence-based diagnosis of tyrosinase-related OCA by using small amounts of the patient’s blood. Methods: Blood spots dried on filter papers were used as sources of genomic DNA. The exons and flanking regions of the tyrosinase gene were amplified by polymerase chain reaction (PCR) and were directly sequenced in both directions. Results: We successfully amplified all exons of the tyrosinase gene by PCR and were able to characterize compound heterozygous mutations of R278X and +ΔC310 in the patient’s gene. Conclusion: Recent advances of PCR-related technology allowed us to use fairly limited samples of blood for sequence analysis of the tyrosinase gene.
Construction of a whole-genome radiation hybrid panel for high-resolution gene mapping in pigs

We have developed a panel of 152 whole-genome radiation hybrids by fusing irradiated diploid pig lymphocytes or fibroblasts with recipient hamster permanent cells. The number and size of the porcine chromosome fragments retained in each hybrid clone were checked by fluorescence in situ hybridization with a SINE probe or by primed in situ labeling (PRINS) with SINE-specific primers. A strategy based on the interspersed repetitive sequence polymerase chain reaction (IRS-PCR) was developed for selected clones to determine if the large fragments painted by the SINE probe corresponded to one pig chromosome or to different fragments of several chromosomes. This strategy was buttressed by a double PRINS approach using primers specific for α-satellite sequences of two different groups of swine chromosomes. Genome retention frequency was estimated for each clone by PCR with 32 markers localized on different porcine chromosomes. Of the 152 hybrids produced, 126 were selected on the basis of cytogenetic content and chromosome retention frequency to construct a radiation hybrid map of swine chromosome 8. Our initial results for this chromosome indicate that the resolution of the radiation hybrid map is 18 times higher than that obtained by linkage analysis.
Creativity in organization: A literature review

This paper aims to report the results of a literary review on research in the field of creativity. The study was conducted systematically on 35 articles in the field of creativity using systematic review methods. The results show that the research area of creativity with the object of general organization has been widely practiced. Most of these studies utilized qualitative methods. In contrast, similar studies within the context of creative study is still limited, both in qualitative research and in quantitative research. Results show the importance of research on creativity, especially in the creative industries. The direction of future research, put forward by researchers is expected to extend understanding on creativity in creative industries.
Merkel Cells in Hyperplastic and Neoplastic Lesions of the Skin

Background: Merkel cells are neuro-endocrine cells present in the basal layer of the human epidermis and the outer root sheath of hair follicles. Objective and Method: In order to gain further insight into the as yet ill-defined involvement of Merkel cells in skin diseases, we studied the distribution of these cells in formalin-fixed, paraffin-embedded sections of 165 inflammatory, hyperplastic or tumoral skin lesions of various anatomic locations, with a monoclonal antibody to keratin 20. Results: Lesions with frequently increased Merkel Cell numbers included actinic keratosis, fibrous papules of the face and some conditions with (immature) hair follicle differentiation. Conclusion: These results suggest that Merkel cell hyperplasia is unrelated to epidermal proliferation but that it is rather specific to a limited number of skin diseases.
PGA/MOEAD: a preference-guided evolutionary algorithm for multi-objective decision-making problems with interval-valued fuzzy preferences

ABSTRACT In this research, we propose a preference-guided optimisation algorithm for multi-criteria decision-making (MCDM) problems with interval-valued fuzzy preferences. The interval-valued fuzzy preferences are decomposed into a series of precise and evenly distributed preference-vectors (reference directions) regarding the objectives to be optimised on the basis of uniform design strategy firstly. Then the preference information is further incorporated into the preference-vectors based on the boundary intersection approach, meanwhile, the MCDM problem with interval-valued fuzzy preferences is reformulated into a series of single-objective optimisation sub-problems (each sub-problem corresponds to a decomposed preference-vector). Finally, a preference-guided optimisation algorithm based on MOEA/D (multi-objective evolutionary algorithm based on decomposition) is proposed to solve the sub-problems in a single run. The proposed algorithm incorporates the preference-vectors within the optimisation process for guiding the search procedure towards a more promising subset of the efficient solutions matching the interval-valued fuzzy preferences. In particular, lots of test instances and an engineering application are employed to validate the performance of the proposed algorithm, and the results demonstrate the effectiveness and feasibility of the algorithm.
Fully convolutional networks for segmenting images from an embedded camera

This paper describes a Fully Convolutional Network (FCN) to segment images from a compact stereo imaging sensor attached to a robot, i.e., a configurable DUO M® stereo camera embedded onto a robot to provide low-level computer vision functions. This robot is named LEIA-1 and carries a NVIDIA Jetson TK1® platform to execute high-level robotics vision, planning and decision making algorithms. Since the TK1 board is not dedicated solely to robotics vision, the FCN architecture should be light enough to consume limited resources. The FCN described in this paper was implemented and prototyped with Python, Keras, and Theano. Also, we trained and validated the FCN architecture using an adaptation of the dataset known as Playing for Data to match the embedded camera specifications. The results reveal the viability of integrating FCNs to processing platforms attached to robots and use their SoC/GPU power to segment indoors/outdoors captured images.
Home security and energy efficient home automation system using arduino

The project aims to provide an efficient, low-cost automated energy management system for houses. It also provides a facility for surveillance of the house. The system has been built after evaluating the utility features of surveillance and energy management systems available at present and is an attempt to improve these features. In addition to providing a cost-effective solution for energy management in the household, it also provides features to cater to natural disasters like fire. The system is built on an Arduino UNO microcontroller board and uses embedded C as the programming language which provides a facility of easier coding for new features.
Adaptive Neighborhood Selection for Multiobjective Optimization Problems

Abstract It is generally that the conﬂict between the convergence and distribution is deteriorated with the increase of the number of objectives. Furthermore, Pareto dominance loses its eﬀectiveness in many objective problems. Therefore, a more valid selection mechanism should be proposed to maintain the two properties. This paper presents a multiobjective evolutionary algorithm, called Adaptive Neighborhood Selection for Multiobjective evolutionary algorithm (ANS-MOEA), to deal with multiobjectives optimization problems (MOPs). The method de-ﬁnes the ability of every individual with two categories of information, convergence information (CI) and distribution information (DI). In the critical layer, well-converged individual is selected ﬁrstly in the population, and its neighbors, calculated by DI, are pushed into neighbor collection soon afterwards. Finally, the proper distribution of the population is ensured by competition so that large DI goes back to the population and low DI remains in the collection. Four state-of-the-art multiobjective evolutionary algorithms are selected as the competitive algorithms to validate ANS-MOEA. The experimental results show that ANS-MOEA can solve a many objective optimization problems and generate a
An overview of emerging pattern mining in supervised descriptive rule discovery: taxonomy, empirical study, trends, and prospects

Emerging pattern mining is a data mining task that aims to discover discriminative patterns, which can describe emerging behavior with respect to a property of interest. In recent years, the description of datasets has become an interesting field due to the easy acquisition of knowledge by the experts. In this review, we will focus on the descriptive point of view of the task. We collect the existing approaches that have been proposed in the literature and group them together in a taxonomy in order to obtain a general vision of the task. A complete empirical study demonstrates the suitability of the approaches presented. This review also presents future trends and emerging prospects within pattern mining and the benefits of knowledge extracted from emerging patterns. WIREs Data Mining Knowl Discov 2018, 8:e1231. doi: 10.1002/widm.1231
Cutting Edge: De Novo Glucocorticoid Synthesis by Thymic Epithelial Cells Regulates Antigen-Specific Thymocyte Selection

Glucocorticoid (GC) signaling in thymocytes counters negative selection and promotes the generation of a self-tolerant yet Ag-responsive T cell repertoire. Whereas circulating GC are derived from the adrenals, GC are also synthesized de novo in the thymus. The significance of this local production is unknown. In this study we deleted 11β-hydroxylase, the enzyme that catalyzes the last step of GC biosynthesis, in thymic epithelial cells (TEC) or thymocytes. Like GC receptor–deficient T cells, T cells from mice lacking TEC-derived but not thymocyte-derived GC proliferated poorly to alloantigen, had a reduced antiviral response, and exhibited enhanced negative selection. Strikingly, basal expression of GC-responsive genes in thymocytes from mice lacking TEC-derived GC was reduced to the same degree as in GC receptor–deficient thymocytes, indicating that at steady-state the majority of biologically active GC are paracrine in origin. These findings demonstrate the importance of extra-adrenal GC even in the presence of circulating adrenal-derived GC.
Cellular Composition of the Adult Rat Anterior Pituitary Is Influenced by the Neonatal Sex Steroid Environment

Growth hormone (GH) and prolactin (PRL) secretion differ significantly between adult males and females and this is due, at least in part, to the postpubertal hormone environment which affects GH and PRL gene expression, as well as somatotrope and lactotrope proliferation. However, the role of the neonatal steroid environment in this phenomenon is less well understood. We have used in situ hybridization to determine the number of GH and PRL mRNA containing cells, as well as the level of expression of these two hormones and of the pituitary transcription factor 1 (Pit-1). Neonatally castrated male rats that had been exposed to testosterone during the neonatal period, adulthood or during both periods, males castrated as adults, normal adult males and normal proestrous females were used. Orchidectomy of adult rats had no effect on the number of somatotropes or lactotropes, but significantly reduced GH and PRL mRNA levels. Neonatal castration significantly reduced the percentage of somatotropes and increased that of lactotropes in the adult male. In addition, GH and Pit-1 mRNA levels were reduced significantly, but PRL mRNA levels were not modified. Treatment of neonatally castrated males with testosterone during the neonatal period significantly increased the percentage of somatotropes and decreased the percentage of lactotropes compared to vehicle-treated animals. It also increased GH and Pit-1 mRNA levels, but did not affect PRL mRNA levels. Adult testosterone treatment significantly increased the percentage of both somatotropes and lactotropes, as well as GH, PRL and Pit-1 mRNA levels. Treatment of neonatally castrated males with testosterone during both the neonatal and adult periods returned the percentage of somatotropes and lactotropes, as well as GH, PRL and Pit-1 mRNA levels, to that of the intact male. These results suggest that, although the postpubertal steroid environment is important in determining anterior pituitary hormone synthesis and cellular composition, the neonatal steroid environment also plays an important role in this phenomenon.
Meta-analysis of randomized controlled trials challenging the usefulness of purgative preparation before small-bowel video capsule endoscopy

Abstract Background The usefulness of purgative preparation before small-bowel video capsule endoscopy is controversial. We aimed to examine the effect of purgative preparation on small-bowel video capsule endoscopy outcomes. Methods We performed literature searches in MEDLINE and the Cochrane library for randomized controlled trials evaluating the effect of purgative preparation (polyethylene glycol, sodium phosphate, others) vs. clear-liquid diet/fasting in patients undergoing small-bowel capsule endoscopy. Meta-analysis outcomes included the examination’s diagnostic yield, small-bowel mucosal visualization quality, the examination’s completion rate, and gastric and small-bowel transit times. The effect size on study outcomes was calculated using a fixed- or random-effect model, as appropriate, and is shown as the risk ratio (RR) with 95 % confidence interval (CI). Results We identified 12 eligible trials with 17 sets of data including 1221 subjects. Significant heterogeneity was detected with no evidence of publication bias. As compared with clear-liquid diet, purgative bowel preparation did not increase capsule endoscopy diagnostic yield (RR 1.17 [95 %CI 0.97 to 1.40]; P = 0.11). Neither the small-bowel mucosal visualization quality (RR 1.14 [95 %CI 0.96 to 1.35]; P = 0.15) nor completion rate for the examination (RR 0.99 [95 %CI 0.95 to 1.04]; P = 0.76) significantly improved after purgative preparation. Purgatives also had no effect on video capsule endoscopy gastric and small-bowel transit times. Conclusions Our analysis challenges the usefulness of purgative preparation for improving the diagnostic yield of small-bowel video capsule endoscopy and the quality of small-bowel mucosal visualization.
An evaluation of a peer support intervention for student mental health

Abstract Background: Peer support is support provided by and for people with similar experiences. As students turn to peers for support with their mental health, peer support may provide an opportunity to engage students at an informal level and avoid some barriers to help-seeking. Aims: The study aimed to identify students likely to attend peer support and evaluate the acceptability and impact of the intervention. Methods: A six-part peer-led course for mild depression, based on behavioural activation and implementation intentions, was evaluated across eight UK universities with 65 students participating in the evaluation. The evaluation focused on mental wellbeing. Results: Participants were predominately female and had been experiencing anxiety or depression for more than one year. Most participants had already approached professional services for support. At least 57% of participants attended more than one session and 34% completed the course. Students with lower levels of mental wellbeing were more likely to complete the course. For students returning, there was a significant increase in mental wellbeing. Conclusions: Structured peer support for depression may have benefits in improving student mental wellbeing. However, this is unlikely to have a substantive effect in improving early and preventative intervention.
Rationale and Background on Tumor-Treating Fields for Glioblastoma.

BACKGROUND More than 150 years after the first description of glioma cells, patients with glioblastoma (GBM) continue to have a poor prognosis despite standard-of-care therapy. With the introduction of tumor-treating fields (TTFields) therapy for the treatment of recurrent GBM in 2011 and for newly diagnosed GBM in 2015, the opportunity to increase progression-free survival and overall survival while improving quality of life provides a welcome option. OBJECTIVES This article describes how TTFields therapy may be used in the treatment of patients with recurrent GBM. METHODS This article provides oncology nurses with two case studies that examine how TTFields therapy can be integrated into the overall treatment paradigm. FINDINGS These two patient case studies demonstrate the autonomy and lack of adverse effects that TTFields therapy offers to patients with GBM.
Up-regulation of hexokinase II contributes to rituximab-chemotherapy resistance and is a clinically relevant target for therapeutic development

In order to identify cellular pathways associated with therapy-resistant aggressive lymphoma, we generated rituximab-resistant cell lines (RRCL) and found that the acquirement of rituximab resistance was associated with a deregulation in glucose metabolism and an increase in the apoptotic threshold leading to chemotherapy resistance. Hexokinase II (HKII), the predominant isoform overexpressed in cancer cells, has dual functions of promoting glycolysis as well as inhibiting mitochondrial-mediated apoptosis. We found that RRCL demonstrated higher HKII levels. Targeting HKII resulted in decreased mitochondrial membrane potential, ATP production, cell viability; and re-sensitization to chemotherapy agents. Analyzed gene expression profiling data from diffuse large B-cell lymphoma patients, high-HKII levels were associated with a shorter progression free survival (PFS) and/or overall survival (OS). Our data suggest that over-expression of HKII is associated with resistance to rituximab and chemotherapy agents in aggressive lymphoma and identifies this enzyme isoform as a potential therapeutic target.
Two simple media for the demonstration of pyocyanin and fluorescin.

Abstract Two simple media for the enhancement of pigment production by certain organisms of the Pseudomonas genus are described. The results of comparative studies employing these media, certain synthetic broths, and some commonly used dehydrated preparations are reported. One hundred (93 per cent) of the 107 strains of Pseudomonas studied were detected by pigment production on medium B; all 107 strains could be detected by the combined use of Heart Infusion agar and 27 per cent on Tryptose agar. The reactions produced strains elaborated a water-soluble pigment; 40 per cent were positive on Difco media A and B. On Difco Proteose peptone No. 3 agar, 77 per cent of the same on the two media by organisms belonging to certain other genera are described.