Miracle-dz/UniFAR-FTUs huggingface dataset:
Hypoxia Aggravates Inhibition of Alveolar Epithelial Na-Transport by Lipopolysaccharide-Stimulation of Alveolar Macrophages

Inflammation and hypoxia impair alveolar barrier tightness, inhibit Na- and fluid reabsorption, and cause edema. We tested whether stimulated alveolar macrophages affect alveolar Na-transport and whether hypoxia aggravates the effects of inflammation, and tested for involved signaling pathways. Primary rat alveolar type II cells (rA2) were co-cultured with rat alveolar macrophages (NR8383) or treated with NR8383-conditioned media after stimulation with lipopolysaccharide (LPS; 1 µg/mL) and exposed to normoxia and hypoxia (1.5% O2). LPS caused a fast, transient increase in TNFα and IL-6 mRNA in macrophages and a sustained increase in inducible nitric oxide synthase (NOS2) mRNA in macrophages and in rA2 cells resulting in elevated nitrite levels and secretion of TNF-α and IL-6 into culture media. In normoxia, 24 h of LPS treated NR8383 decreased the transepithelial electrical resistance (TEER) of co-cultures, of amiloride-sensitive short circuit current (ISCΔamil); whereas Na/K-ATPase activity was not affected. Inhibition was also seen with conditioned media from LPS-stimulated NR8383 on rA2, but was less pronounced after dialysis to remove small molecules and nitrite. The effect of LPS-stimulated macrophages on TEER and Na-transport was fully prevented by the iNOS-inhibitor L-NMMA applied to co-cultures and to rA2 mono-cultures. Hypoxia in combination with LPS-stimulated NR8383 totally abolished TEER and ISCΔamil. These results indicate that the LPS-stimulation of alveolar macrophages impairs alveolar epithelial Na-transport by NO-dependent mechanisms, where part of the NO is produced by rA2 induced by signals from LPS stimulated alveolar macrophages.
Everything Is Timelessly Connected: Metaphysics, Physics, Consciousness, Spacetime Travel, DNA, and the <i>Dry Bones Prophesy</i> (<i>Ezekiel Ch. 37</i>)

This paper provides a perception that all things are connected. Starting with the perception of Metaphysics and how matter exists out of total void, complementary matter, or dark matter, the incompleteness of Einstein relativistic theory. Multi spacetime universes and the jump drive for jumping within and between spacetime universes. Warp drive for space travel. DNA as sequence of momentary frequencies and how it related to Ezekiel’s dry bones prophecy. The outcome of neural patterns as cords of consciousness, consciousness as the collection of all cords of consciousness and the lack of uniqueness of individual consciousness. Finally, all things are cords of consciousness. in the new location by the jump drive inverse Fourier transform has no difference from Ezekiel dry bones restoration prophecy. Both cases deal with signal restoration.
Seeing Women, Strengthening Democracy: How Women in Politics Foster Connected Citizens. By Magda Hinojosa and Miki Caul Kittilson. New York: Oxford University Press, 2020. 180 pp. $74.00 (cloth). https://doi.org/10.1093/oso/9780197526941.001.0001.

The idea of symbolic representation focuses on the emotions and responses that representatives invoke in constituents (Pitkin 1967). One of the key questions driving the study of women ’ s symbolic representation is how constituents, and particularly women, react to seeing women present in politics. In their book Seeing Women, Strengthening Democracy: How Women in Politics Foster Connected Citizens , Magda Hinojosa and Miki Caul Kittilson explore whether a jump in the presence of women in politics leads to greater political connectedness among women, measured in terms of their levels of political support and political engagement.
Unravelling t-KIBS performance: leadership, organisational culture, and learning as boosters of service innovation

ABSTRACT The search for better organisational performance requires leaders to promote knowledge-based solutions, encouraging a culture focused on continuous learning, with innovation as the key to increasing competitiveness. Organisations that use intensive knowledge based on technology -t-KIBS- play an important role in the creation, transfer, and integration of knowledge, facilitating innovation for their customers. The objective of this study was to assess the joint influence of transformational leadership, organisational culture, organisational learning, and service innovation on the firm performance of tech firms. This quantitative, survey-typed, and cross-sectional research was conducted in a sample of 242 t-KIBS firms. For data analysis, we used structural equations modelling by partial least squares. Our findings suggest that transformational leadership positively influences organisational culture and learning, which positively influence service innovation and organisational performance. Therefore, to overcome market challenges, surprise customers, and improve organisational performance and innovativeness, t-KIBS leaders must stimulate employees, improving organisational learning capability.
Signatures of the A 2 term in ultrastrongly coupled oscillators

We study a bosonic matter excitation coupled to a single-mode cavity field via electric dipole. Counter-rotating and $A^2$ terms are included in the interaction model, ${\mathbf A}$ being the vector potential of the cavity field. In the ultrastrong coupling regime the vacuum of the bare modes is no longer the ground state of the Hamiltonian and contains a nonzero population of polaritons, the true normal modes of the system. If the parameters of the model satisfy the Thomas-Reiche-Kuhn sum rule, we find that the two polaritons are always equally populated. We show how this prediction could be tested in a quenching experiment, by rapidly switching on the coupling and analyzing the radiation emitted by the cavity. A refinement of the model based on a microscopic minimal coupling Hamiltonian is also provided, and its consequences on our results are characterized analytically.
A Complete Family of Kinematically-Simple Joint Layouts: Layout Models, Associated Displacement Problem Solutions and Applications

Podhorodeski and Pittens (1992, 1994) and Podhorodeski (1992) defined a kinematically-simple (KS) layout as a manipulator layout that incorporates a spherical group of joints at the wrist with a main-arm comprised of successfully parallel or perpendicular joints with no unnecessary offsets or link lengths between joints. Having a spherical group of joints within the layouts ensures, as demonstrated by Pieper (1968), that a closed-form solution for the inverse displacement problem exists. Using the notation of possible joint axes directions shown in Figure 1 and arguments of kinematic equivalency and mobility of the layouts, Podhorodeski and Pittens (1992, 1994) showed that there are only five unique, revolute-only, main-arm joint layouts representative of all layouts belonging to the KS family. These layouts have joint directions CBE, CAE, BCE, BEF, and AEF and are denoted KS 1 to 5 in Figure 2.
Suitability of Various Lidar and Radar Sensors for Application in Robotics: A Measurable Capability Comparison

Lidar and radar sensors are widely used to obtain depth information for various applications in the field of robotics, such as navigation <xref ref-type="bibr" rid="ref1">[1]</xref>, collision avoidance <xref ref-type="bibr" rid="ref2">[2]</xref>, surveillance <xref ref-type="bibr" rid="ref3">[3]</xref>, and map generation <xref ref-type="bibr" rid="ref4">[4]</xref>. These two sensors are becoming increasingly popular as perception systems for autonomous mobile robots. However, as a result of their versatility and popularity, lidar and radar sensors come in a variety of specifications, sizes, and prices. Consequently, it has become essential to quantitatively evaluate these two sensors from various situational perspectives. This is required for a comprehensive selection of the most appropriate sensors or combinations thereof for the target applications.
Testes dicoticos verbais e não-verbais em crianças com doença cerebrovascular

o presente estudo em doenca cerebrovascular (DCV) teve por objetivo caracterizar a habilidade de atencao seletiva em criancas e adolescentes a partir da aplicacao de testes auditivos dicoticos com estimulos verbais e nao-verbais. Foram incluidos pacientes com DCV de comprometimento unilateral e episodio unico confirmados pela avaliacao clinica neurologica e exames de imagem como tomografia computadorizada e/ou ressonância magnetica cerebral. Todos foram acompanhados desde a fase aguda da doenca e apresentavam sensibilidade auditiva, habilidades de linguagem, nivel de atencao e funcao cognitiva compativeis com as tarefas exigidas, confirmados por avaliacao fonoaudiologica e neuropsicologica. Foram avaliadas 13 criancas de ambos os sexos (7 meninos) com idades entre 7 e 16 anos, grupo proposito (GP), durante a realizacao de tarefas de integracao e separacao binaural. Os resultados foram pareados com grupo controle (GC) formado por criancas destras, do mesmo sexo, idade e nivel socio-economico do GP. Os testes aplicados foram o dicotico nao-verbal de escuta direcionada e os verbais, consoante-voga~ dicotico de digitos e de dissilabos alternados (Staggered Spondaic Word Test/SSW). Foi possivel constatar no teste nao-verbal de escuta direcionada assimetria de respostas entre as orelhas direita e esquerda na etapa de atencao livre, e dificuldade em focalizar a atencao. para a orelha solicitada nas etapas de atencao direcionada. No teste consoantevogal foi constatada direcao variavel da assimetria perceptual na etapa de atencao livre e, dificuldade em dirigir a atencao para a orelha solicitada nas etapas de atencao direcionada. No teste de digitos e de dissilabos alternados foram constatadas alteracoes ipsilaterais, contralaterais ou bilaterais em relacao ao hemisferio acometido pela DCV Abstract
Altered Lung Microbiome and Metabolome Profile in Children With Pulmonary Arterial Hypertension Associated With Congenital Heart Disease

Backgrounds Pulmonary arterial hypertension (PAH) is characterized by progressive pulmonary vascular functional and structural changes, resulting in increased pulmonary vascular resistance and eventually right heart failure and death. Congenital Left-to-Right shunts (LTRS) is one type of congenital heart disease (CHD) and PAH associated with the congenital Left-to-Right shunt (PAH-LTRS) is a severe disease in children. However, changes in the lung microbiome and their potential impact on PAH-LTRS have not been not fully studied. We hypothesized that lung microbiota and their derived metabolites have been disturbed in children with PAH-LTRS, which might contribute to the progression and outcomes of PAH-LTRS. Methods In this study, 68 age- and sex-matched children of three different groups (patients with PAH-LTRS cohort, patients with LTRS but have no pathologic features of PAH cohort, and healthy reference cohort) were enrolled in the current study. Bronchoalveolar lavage fluid samples from these participants were conducted for multi-omics analysis, including 16S rRNA sequencing and metabolomic profiling. Data progressing and integration analysis were performed to identify pulmonary microbial and metabolic characteristics of PAH-LTRS in children. Results We found that microbial community density was not significantly altered in PAH-LTRS based on α-diversity analysis. Microbial composition analysis indicated phylum of Bacteroidetes was that less abundant while Lactobacillus, Alicycliphilus, and Parapusillimonas were significantly altered and might contribute to PAH in children with LTRS. Moreover, metabolome profiling data showed that metabolites involved in Purine metabolism, Glycerophospholipid metabolism, Galactose metabolism, and Pyrimidine metabolism were also significantly disturbed in the PAH-LTRS cohort. Correlation analysis between microbes and metabolites indicated that alterations in the microbial composition from the lung microbiota could eventually result in the disturbance in certain metabolites, and might finally contribute to the pathology of PAH-LTRS. Conclusion Lung microbial density was not significantly altered in patients with PAH-LTRS. Composition analysis results showed that the relative microbiome abundance was different between groups. Metabolome profiling and correlation analysis with microbiota showed that metabolome also altered in children with PAH-LTRS. This study indicated that pulmonary microbes and metabolites disturbed in PAH-LTRS could be potentially effective biomarkers and provides valuable perspectives on clinical diagnosis, treatment, and prognosis of pediatric PAH-LTRS.
A Real-Time Hardware Intrusion Detection System and a Classifying Features Algorithm

Abstract Nowadays, everybody needs to secure his/her activities. Existing levels of cyber-criminals need technology for detecting malicious activity. This work proposes a real-time Hardware IDS implemented on FPGA and an algorithm for classifying features from network traffic through the network interface card (NIC). It minimizes search time for extracting statistical features from connection records stored in connection queues to memory references. Therefore, it can detect most internal and external network attacks. A decision tree classifier is used as an inference engine and gives a high detection rate of 99.93%.
Skeptical Employers: Experimental Evidence on Biased Beliefs Constraining Firm Growth

Does low trust in workers discourage firms from hiring? We conduct an experiment in Ghana with real entrepreneurs who have the option to hire anonymous workers for a trivial but tedious task. Shirking attracts no penalty and completion of the task is an indicator of trustworthiness. We elicit employers' expectations and study how they change with random signals of workers' previous behaviour. We find that employers underestimate workers' trustworthiness, which reduces hiring and profits. Negative signals lower employers' expectations, while positive signals do not affect them. This asymmetry can help to sustain an equilibrium with limited experimentation and biased beliefs.
Computational Evaluation of Al-Decorated g-CN Nanostructures as High-Performance Hydrogen-Storage Media

Density functional theory (DFT) calculations were employed to solve the electronic structure of aluminum (Al)-doped g-CN and further to evaluate its performance in hydrogen storage. Within our configurations, each 2 × 2 supercell of this two-dimensional material can accommodate four Al atoms, and there exist chemical bonding and partial charge transfer between pyridinic nitrogen (N) and Al atoms. The doped Al atom loses electrons and tends to be electronically positive; moreover, a local electronic field can be formed around itself, inducing the adsorbed H2 molecules to be polarized. The polarized H2 molecules were found to be adsorbed by both the N and Al atoms, giving rise to the electrostatic attractions between the H2 molecules and the Al-doped g-CN surface. We found that each 2 × 2 supercell can adsorb at most, 24 H2 molecules, and the corresponding adsorption energies ranged from −0.11 to −0.31 eV. The highest hydrogen-storage capacity of the Al-doped g-CN can reach up to 6.15 wt%, surpassing the goal of 5.50 wt% proposed by the U.S. Department of Energy. Additionally, effective adsorption sites can be easily differentiated by the electronic potential distribution map of the optimized configurations. Such a composite material has been proven to possess a high potential for hydrogen storage, and we have good reasons to expect that in the future, more advanced materials can be developed based on this unit.
See something, say something? exploring the gap between real and imagined moral courage

ABSTRACT Research shows that people often do not intervene to stop immoral action from happening. However, limited information is available on why people fail to intervene. Two preregistered studies (Ns = 248, 131) explored this gap in the literature by staging a theft in front of participants and immediately interviewing them to inquire about their reasons for intervening or not intervening. Across both studies, most participants did not try to stop the theft or even report it to the experimenter afterward. Furthermore, many participants reported confusion and inattention as precursors to nonintervention, yielding insight into what inhibits moral courage.
MODLPR: Stata module to estimate long memory in a timeseries

modlpr computes a modified form of the Geweke/Porter-Hudak (GPH, 1983) estimate of the long memory (fractional integration) parameter, d, of a timeseries, proposed by Phillips (1999a, 1999b). Distinguishing unit-root behavior from fractional integration may be problematic, given that the GPH estimator is inconsistent against d>1 alternatives. This weakness of the GPH estimator is solved by Phillips' Modified Log Periodogram Regression estimator, in which the dependent variable is modified to reflect the distribution of d under the null hypothesis that d=1. Removal of a linear trend is now the default behavior. This is version 1.1. 7 of the software, updated from that published in STB-57, and compatible with Stata version 8 syntax. It may be applied to a single timeseries in a panel with the if qualifier or to all timeseries with the by prefix.
Percent positivity and phylogenetic analysis of Mycoplasma gallisepticum and Mycoplasma synoviae in commercial poultry from the different States of India

Background and Aim: The Indian and global poultry industries suffer significant economic losses due to Mycoplasma gallisepticum (MG) and Mycoplasma synoviae (MS) infections, which adversely affect egg production, hatchability, weight gain, and feed efficiency in farms, thus decreasing the overall production efficiency. This study aimed to determine the percent positivity and phylogenetic analysis of MG, MS, and co-infection of both mycoplasmas in commercial poultry farms across different states of India from 2017 to 2021. Materials and Methods: A total of 3620 tracheal or choacal swabs were collected from breeder and layer farms showing clinical signs of avian mycoplasma infections from commercial poultry farms across India, and the percent positivity for MG, MS, and co-infection of both mycoplasmas were determined by Polymerase chain reaction using the 16S rRNA and vlhA genes amplification, respectively. Phylogenetic analysis was carried out by sequencing the mgc2 and vlhA genes of 2 samples of MG and 24 samples of M. synoviae to gain insight into the genetic variability of Indian strains. The data were then compared with other Indian strains, vaccines strains, and strains from other countries. Results: Our data shows the percent positivity of MG, MS, and co-infection of both MG and MS was 6.43%, 23.61%, and 15.49%, respectively. The phylogenetic relationship between MG and MS was determined using the vlhA and mgc2 genes, revealing two samples of MG and 24 samples of MS clustered with other Indian strains. M. synoviae MSM22 and previously studied M. synoviae MGS 482 clustered with vaccine strain M. synoviae MS-H. Conclusion: Mycoplasma synoviae infections in breeder, layer, and in both is predominant compared to MG across the states investigated in India. Sequenced samples of MG and MS showed evolutionary relationships with the previously studied Indian strains of MG and MS. These findings support our view that monitoring chickens for avian mycoplasma infections are of paramount significance. It further lends credence to the contention that such information will pave the way for the development of a home-grown vaccination control program and thus safeguard the poultry sector against mycoplasma infections.
SUPPLEMENT TO “THE EFFECT OF JOB LOSS AND UNEMPLOYMENT INSURANCE ON CRIME IN BRAZIL” (Econometrica, Vol. 90, No. 4, July 2022, 1393–1423)

Note: This table shows the distribution of criminal prosecutions, by type of offense. The first column shows the share of prosecutions for each type of offense across all criminal prosecutions. These shares do not add up to 100% because it is not possible to observe the specific charge for 17% of all cases and because some cases cover multiples charges. The second column shows the share of prosecutions initiated in flagrante within all prosecutions for each type of charge.
Impact of dislocation density on the ferroelectric properties of ScAlN grown by molecular beam epitaxy

We report on the effect of dislocation density on the ferroelectric properties of single-crystalline ScAlN thin films grown by molecular beam epitaxy. Wurtzite phase and atomically smooth ScAlN films have been grown on bulk GaN, GaN on sapphire, and GaN on Si substrates with dislocation densities ranging from ∼107 to 1010 cm−2. Despite the significant difference in dislocation density, ferroelectricity is observed in all three samples. The presence of high densities of dislocations, however, results in enhanced asymmetric P–E loops and overestimated remnant polarization values. Further measurements show that the leakage current and breakdown strength can be improved with decreasing dislocation density. Detailed studies suggest that trapping/detrapping assisted transport is the main leakage mechanism in epitaxial ferroelectric ScAlN films. This work sheds light on the essential material quality considerations for tuning the ferroelectric property of ScAlN toward integration with mainstream semiconductor platforms, e.g., Si, and paves the way for next-generation electronics, optoelectronics, and piezoelectronics.
The Bundling of Business Intelligence and Analytics

ABSTRACT Business Intelligence (BI) and analytics are often bundled together in the Information Systems (IS) literature as BI&A. We argue that BI and analytics are different information systems that are used differently, require different tools and technical skills, and are targeted at different audiences. We posit that this bundling is not relevant to the practice, rather the result of a fashion wave inspired by Gartner technology trends. We argue that such misrepresentation disassociates IS research from practice. We performed a pilot qualitative study as well as secondary data analysis on job data from Indeed.com to validate our arguments. The paper contributes to the IS research by critiquing the status quo on BI&A, which has existed since 2012. Implications of the unbundling of BI and analytics for future research and academics are discussed.
The on-line travelling salesman problem on the line

In the on-line travelling salesman problem the points to be visited are not known in advance but given while the salesman is en route. This problem has been posed and studied by Ausiello, Feuerstein, Leonardi, Stougie, and Talamo (Algoritmica 29, 2001, 560-581). With respect to the competitive ratio of deterministic algorithms for this problem one case remained open, which concerned the problem on the real line. Ausiello et al. show a lower bound on the competitive ratio for any deterministic algorithm of (9 + vl7)/8 ~ 1.64, whereas the best algorithm so far is 7/4-competitive. We close this gap by designing an algorithm that has competitive ratio (9 + vl7)/8. An alternative on-line model proposed by Blom, Krumke, de Paepe, and Stougie (INFORMS Journal on Computing 13, 2001, 138-148) in troduces a notion of fairness. Also under this model the real line ap peared to be the harder case to tackle. We derive a lower bound of (5 + -157)/8 ~ 1.57 on the competitive ratio of any deterministic algo rithm for this version of the problem. In order not to leave any gap in the research on deterministic algorithms for the on-line travelling salesman problem, we complement this lower bound with an algorithm that has a matching competitive ratio.