Miracle-dz/UniFAR-FTUs huggingface dataset:
A co-registration investigation of inter-word spacing and parafoveal preview: Eye movements and fixation-related potentials

Participants’ eye movements (EMs) and EEG signal were simultaneously recorded to examine foveal and parafoveal processing during sentence reading. All the words in the sentence were manipulated for inter-word spacing (intact spaces vs. spaces replaced by a random letter) and parafoveal preview (identical preview vs. random letter string preview). We observed disruption for unspaced text and invalid preview conditions in both EMs and fixation-related potentials (FRPs). Unspaced and invalid preview conditions received longer reading times than spaced and valid preview conditions. In addition, the FRP data showed that unspaced previews disrupted reading in earlier time windows of analysis, compared to string preview conditions. Moreover, the effect of parafoveal preview was greater for spaced relative to unspaced conditions, in both EMs and FRPs. These findings replicate well-established preview effects, provide novel insight into the neural correlates of reading with and without inter-word spacing and suggest that spatial selection precedes lexical processing.
Mir-5100 Mediates Proliferation, Migration and Invasion of Oral Squamous Cell Carcinoma Cells Via Targeting SCAI

Abstract Purpose We aimed to investigate the role of microRNA-5100 (miRNA-5100) in oral squamous cell carcinoma (OSCC) and its underlying mechanisms. Material/Methods: The expression of miR-5100 and suppressor of cancer cell invasion (SCAI) in OSCC cell lines were examined. A luciferase reporter assay was applied to confirm the combination between miR-5100 and SCAI. Then, miR-5100 inhibitor or small hairpin RNA (shRNA)-SCAI were transfected into cells. Cell Counting Kit-8 assay was executed for testing cell proliferation ability. Flow cytometry assay was exploited for measuring cell cycle. Invasion and migration of OSCC cells were assessed using Transwell assay and wound healing assay. The expression of proteins were detected using western blotting. Results The results demonstrated that the level of miR-5100 was upregulated while SCAI was downregulated in OSCC cells. SCAI was verified as a direct target of miR-5100. MiR-5100 silencing suppressed proliferation of OSCC cells, increased cells in the G1 and G2 phases, and reduced those in the S phase, which was reversed after transfection with shRNA-SCAI. Moreover, miR-5100 inhibitor downregulated the expression of cyclin-dependent kinase-2 (CDK-2) and cyclinD1, accompanied by upregulation in p27 expression, whereas SCAI silencing had the opposite results. The invasion and migration abilities of OSCC cells were reduced after treatment with miR-5100 inhibitor, whereas SCAI silencing suppressed the effects of miR-5100 inhibitor on OSCC cell behaviors. Conclusion These findings suggested that miR-5100 silencing inhibit proliferation, invasion and migration of OSCC cells via upregulating the expression of SCAI, which provides theoretical basis and treatment strategies for the treatment of OSCC.
Genomic and Phenotypic Characterization of a Broad Panel of Patient-Derived Xenografts Reflects the Diversity of Glioblastoma

Purpose: Glioblastoma is the most frequent and lethal primary brain tumor. Development of novel therapies relies on the availability of relevant preclinical models. We have established a panel of 96 glioblastoma patient-derived xenografts (PDX) and undertaken its genomic and phenotypic characterization. Experimental Design: PDXs were established from glioblastoma, IDH-wildtype (n = 93), glioblastoma, IDH-mutant (n = 2), diffuse midline glioma, H3 K27M-mutant (n = 1), and both primary (n = 60) and recurrent (n = 34) tumors. Tumor growth rates, histopathology, and treatment response were characterized. Integrated molecular profiling was performed by whole-exome sequencing (WES, n = 83), RNA-sequencing (n = 68), and genome-wide methylation profiling (n = 76). WES data from 24 patient tumors was compared with derivative models. Results: PDXs recapitulate many key phenotypic and molecular features of patient tumors. Orthotopic PDXs show characteristic tumor morphology and invasion patterns, but largely lack microvascular proliferation and necrosis. PDXs capture common and rare molecular drivers, including alterations of TERT, EGFR, PTEN, TP53, BRAF, and IDH1, most at frequencies comparable with human glioblastoma. However, PDGFRA amplification was absent. RNA-sequencing and genome-wide methylation profiling demonstrated broad representation of glioblastoma molecular subtypes. MGMT promoter methylation correlated with increased survival in response to temozolomide. WES of 24 matched patient tumors showed preservation of most genetic driver alterations, including EGFR amplification. However, in four patient–PDX pairs, driver alterations were gained or lost on engraftment, consistent with clonal selection. Conclusions: Our PDX panel captures the molecular heterogeneity of glioblastoma and recapitulates many salient genetic and phenotypic features. All models and genomic data are openly available to investigators.
Dietary supplementation of plant essential oil improves growth performance, intestinal morphology and health in weaned pigs.

The present study was conducted to explore the effect of plant essential oil (PEO) on growth performance, intestinal morphology and health in weaned pigs. Twenty-four weaned pigs were assigned into four groups fed with a basal diet (CON) or basal diet containing PEO at a concentration of 50 (PEO50), 100 (PEO100) or 200 ppm (PEO200). After 21 days, pigs were slaughtered and blood and tissue samples were collected. Result showed that PEO200 group significantly increased the average daily gain (ADG) compared with CON group (p < .05). Moreover, PEO supplementation significantly improved the digestibility of DM (p < .05). However, it significantly decreased the serum triglyceride and cholesterol concentration (p < .05). Interestingly, PEO supplementation significantly increased the activity of sucrase in the duodenal and the activity of lactase in the jejunal mucosa (p < .05). Moreover, PEO supplementation improved the growth of intestinal mucosa. As compared to the CON group, the jejunum and ileum villus height were significantly elevated in the PEO200 group (p < .05). Importantly, the expression levels of critical genes associated with nutrient transportation (i.e., GLUT2 and SGLT1) and barrier function (occludin) were significantly elevated in the PEO200 group (p < .05). Moreover, the PEO100 and PEO200 group had higher propionic acid concentration and higher total bacterial gene copies in colon digesta than the CON group (p < .05) respectively. These results not only suggest that PEO has a positive role in the regulation of growth and intestinal health in weaned pigs, but also offer a potential candidate substituting the conventionally used antibiotics in the livestock industry.
On the relation between felt trust and actual trust: Examining pathways to and implications of leader trust meta-accuracy.

Research has long emphasized that being trusted is a central concern for leaders (Dirks & Ferrin, 2002), but an interesting and important question left unexplored is whether leaders feel trusted by each employee, and whether their felt trust is accurate. Across 2 field studies, we examined the factors that shape the accuracy of leaders' felt trust-or, their trust meta-accuracy-and the implications of trust meta-accuracy for the degree of relationship conflict between leaders and their employees. By integrating research on trust and interpersonal perception, we developed and tested hypotheses based on 2 theoretical mechanisms-an external signaling mechanism and an internal presumed reciprocity mechanism-that theory suggests shape leaders' trust meta-accuracy. In contrast to the existing literature on felt trust, our results reveal that leader trust meta-accuracy is shaped by an internal mechanism and the presumed reciprocity of trust relationships. We further find that whether trust meta-accuracy is associated with positive relational outcomes for leaders depends upon the level of an employee's actual trust in the leader. Our research contributes to burgeoning interest in felt trust by elucidating the mechanisms underlying trust meta-accuracy and suggesting practical directions for leaders who seek to accurately understand how much their employees trust them. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Rapid crossed responses in an intrinsic hand muscle during perturbed bimanual movements

Mechanical perturbations in one upper limb often elicit corrective responses in both the perturbed as well as its contralateral and unperturbed counterpart. These crossed corrective responses have been shown to be sensitive to the bimanual requirements of the perturbation, but crossed responses (CRs) in hand muscles are far less well studied. Here, we investigate corrective CRs in an intrinsic hand muscle, the first dorsal interosseous (1DI), to clockwise and anticlockwise mechanical perturbations to the contralateral index finger while participants performed a bimanual finger abduction task. We found that the CRs in the unperturbed 1DI were sensitive to the direction of the perturbation of the contralateral index finger. However, the size of the CRs was not sensitive to the amplitude of the contralateral perturbation nor its context within the bimanual task. The onset latency of the CRs was too fast to be purely transcortical (<70 ms) in 12/12 participants. This confirms that during isolated bimanual finger movements, sensory feedback from one hand can influence the other, but the pathways mediating the earliest components of this interaction are likely to involve subcortical systems such as the brainstem or spinal cord, which may afford less flexibility to the task demands. NEW & NOTEWORTHY An intrinsic hand muscle shows a crossed response to a perturbation of the contralateral index finger. The crossed response is dependent on the direction of the contralateral perturbation but not on the amplitude or the bimanual requirements of the movement, suggesting a far less flexible control policy than those governing crossed responses in more proximal muscles. The crossed response is too fast to be purely mediated by transcortical pathways, suggesting subcortical contributions.
An expanded rating curve model to estimate river discharge during tidal influences across the progressive-mixed-standing wave systems

Empirically quantifying tidally-influenced river discharge is typically laborious, expensive, and subject to more uncertainty than estimation of upstream river discharge. The tidal stage-discharge relationship is not monotonic nor necessarily single-valued, so conventional stage-based river rating curves fail in the tidal zone. Herein, we propose an expanded rating curve method incorporating stage-rate-of-change to estimate river discharge under tidal influences across progressive, mixed, and standing waves. This simple and inexpensive method requires (1) stage from a pressure transducer, (2) flow direction from a tilt current meter, and (3) a series of ADP surveys at different flow rates for model calibration. The method was validated using excerpts from 12 tidal USGS gauging stations during baseflow conditions. USGS gauging stations model discharge using a different more complex and expensive method. Comparison of new and previous models resulted in good R2 correlations (min 0.62, mean 0.87 with S.D. 0.10, max 0.97). The method for modeling tidally-influenced discharge during baseflow conditions was applied de novo to eight intertidal stations in the Mission and Aransas Rivers, Texas, USA. In these same rivers, the model was further expanded to identify and estimate tidally-influenced stormflow discharges. The Mission and Aransas examples illustrated the potential scientific and management utility of the applied tidal rating curve method for isolating transient tidal influences and quantifying baseflow and storm discharges to sensitive coastal waters.
Interrelationships Between Pituitary Hormones as Assessed From 24-hour Serum Concentrations in Healthy Older Subjects

Abstract Context Hormones of the hypothalamic-pituitary-target gland axes are mostly investigated separately, whereas the interplay between hormones might be as important as each separate hormonal axis. Objective Our aim is to determine the interrelationships between GH, TSH, ACTH, and cortisol in healthy older individuals. Design We made use of 24-hour hormone serum concentrations assessed with intervals of 10 minutes from 38 healthy older individuals with a mean age (SD) of 65.1 (5.1) years from the Leiden Longevity Study. Cross-correlation analyses were performed to assess the relative strength between 2 24-hour hormone serum concentration series for all possible time shifts. Cross-approximate entropy was used to assess pattern synchronicity between 2 24-hour hormone serum concentration series. Results Within an interlinked hormonal axis, ACTH and cortisol were positively correlated with a mean (95% confidence interval) correlation coefficient of 0.78 (0.74–0.81) with cortisol following ACTH concentrations with a delay of 10 minutes. Between different hormonal axes, we observed a negative correlation coefficient between cortisol and TSH of -0.30 (-0.36 to -0.25) with TSH following cortisol concentrations with a delay of 170 minutes. Furthermore, a positive mean (95% confidence interval) correlation coefficient of 0.29 (0.22–0.37) was found between TSH and GH concentrations without any delay. Moreover, cross-approximate entropy analyses showed that GH and cortisol exhibit synchronous serum concentration patterns. Conclusions This study demonstrates that interrelations between hormones from interlinked as well as different hypothalamic-pituitary-target gland axes are observed in healthy older individuals. More research is needed to determine the biological meaning and clinical consequences of these observations.
Foam Rolling and Muscle and Joint Proprioception After Exercise-Induced Muscle Damage.

CONTEXT Foam rolling (FR) is considered an effective postexercise modality for reducing delayed-onset muscle soreness and enhancing recovery of muscle function. However, the effects of FR on muscle and joint proprioception have not been investigated. OBJECTIVE To examine the effects of FR on muscle and joint proprioception after an intense exercise protocol. DESIGN Controlled laboratory study. SETTING University-based laboratory. PATIENTS OR OTHER PARTICIPANTS A total of 80 healthy, physically active male students were randomly assigned to either the FR (n = 40; age = 22.8 ± 3.3 years, height = 176.4 ± 5.3 cm, mass = 74.2 ± 6.4 kg) or passive-recovery (PR; n = 40; age = 23.0 ± 3.2 years, height = 178.1 ± 5.5 cm, mass = 74.6 ± 6.2 kg) group. INTERVENTION(S) Participants in both groups performed 4 sets of 25 repetitions of voluntary maximal eccentric contractions at 60°/s from 20° to 100° of knee flexion to induce exercise-induced muscle damage. The exercise was followed by either PR or 2 minutes of FR immediately (1 hour) and 24, 48, and 72 hours postexercise. MAIN OUTCOME MEASURE(S) Muscle soreness, pressure-pain threshold, quadriceps-muscle strength, joint position sense, isometric force sense, and threshold to detect passive movement at baseline and immediately, 24, 48, and 72 hours postexercise after FR. RESULTS Foam rolling resulted in decreased muscle pain, increased pressure-pain threshold, improved joint position sense, attenuated force loss, and reduced threshold to detect passive movement compared with PR at 24 and 48 hours postexercise. CONCLUSIONS Foam rolling postexercise diminished delayed-onset muscle soreness and improved recovery of muscle strength and joint proprioception. These results suggested that FR enhanced recovery from exercise-induced damage.
Aged garlic extract and S-allylcysteine increase the GLUT3 and GCLC expression levels in cerebral ischemia.

BACKGROUND During cerebral ischemia, energy restoration through the regulation of glucose transporters and antioxidant defense mechanisms is essential to maintain cell viability. Antioxidant therapy has been considered effective to attenuate brain damage; moreover, the regulation of transcription factors that positively regulate the expression of glucose transporters is associated with this therapy. Recently, it has been reported that the use of antioxidants such as S-allylcysteine (SAC), a component of aged garlic extract (AGE), improves survival in experimental models of cerebral ischemia. OBJECTIVES The aim of this study was to determine the effect of AGE and SAC on the level of mRNA expression of the main neuronal glucose transporter (GLUT3) and the glutamate cysteine ligase catalytic subunit (GCLC) in rats with transient focal cerebral ischemia. MATERIAL AND METHODS Cerebral ischemia was induced in male Wistar rats by middle cerebral artery occlusion (MCAO) for 2 h. The animals were sacrificed after different reperfusion times (0-48 h). Animals injected with AGE (360 mg/kg, intraperitoneally (i.p.)) and SAC (300 mg/kg, i.p.) at the beginning of reperfusion were sacrificed after 2 h. The mRNA expression level was analyzed in the fronto-parietal cortex using quantitative polymerase chain reaction (qPCR). RESULTS Two major increases in GLUT3 expression at 1 h and 24 h of reperfusion were found. Both treatments increased GLUT3 and GCLC mRNA levels in control and under ischemic/reperfusion injury animals. CONCLUSIONS This data suggests that SAC and AGE might induce neuroprotection, while controlling reactive oxygen species (ROS) levels, as indicated by the increase in GCLC expression, and regulating the energy content of the cell by increasing glucose transport mediated by GLUT3.
A clinical effect of temozolomide in patients with malignant glioma

Objective: To study the efficacy and security of temozolomide (TMZ) in patients with malignant glioma. Methods: 70 patients,diagnosed malignant glioma by pathology,were randomly divided into two groups.TMZ or Semustine (CCNU) was administered respectively according to body surface area,and 2～6 treatment courses were performed in these cases.Meantime,clinical experience and contrast-enhanced CT or GD-MRI scan were performed every course.The progression free survival (PFS),image based tumor response,quality of life,and security were evaluated respectively.Results: The progression free survival rates of patients in TMZ group were higher than that in CCNU group with significant difference (P0.05). Image based tumor compelte response rates were 22.85% in TMZ group and 8.57% in CCNU group (P0.05). Patients with TMZ treatment experienced better quality of life and fewer adverse drug events than those with CCNU treatment.Conclusion: TMZ can evidently prolong the progression free survival time of patients by limiting aggressive growth of malignant glioma effectively.TMZ shows more efficient tumor response rate with good tolerability and safety compared with CCNU.
The use of internet language enhances creative performance

Abstract Internet language is a creative product of the rapid development of computer-mediated communication. The present study was to investigate whether the use of Internet language enhances creative problem solving. In Study 1, sixty-two selected participants were equally divided into two groups according to their use experience of Chinese Internet language, and then both more and less experienced groups were asked to complete Chinese remote associates test and Chinese chengyu riddles. Results showed that the more experienced group performed significantly better in both the creative tasks. In Study 2, forty-six participants were randomly divided into two groups. The experimental group was asked to learn Chinese Internet Language, while the control group was asked to learn scientific terminology. Two groups completed the aforementioned creative tasks in pretest and post-test. Results showed that the interaction between the group and test order was significant in Chinese chengyu riddle solving, in which the experimental group had a significantly higher average score in post-test than pretest. And there was no difference for the control group. These findings supported that Internet language use benefited creative problem solving, and it might be a convenient way in the practice of promoting creativity.
Response to Letter Regarding ‘Dimensions of Elongated Mineral Particles: A Study of More Than 570 Fibers From More Than 90 Cases with Implications for Pathogenicity and Classification as Asbestiform vs. Cleavage Fragments’

Dr. Finkelstein criticizes our paper concerning ‘Dimensions of Elongated Mineral Particles: A Study of More Than 570 Fibers From More Than 90 Cases with Implications for Pathogenicity and Classification as Asbestiform vs. Cleavage Fragments’, citing numerous issues in the study by Harper et al. regarding the difficulties in classifying elongated mineral particles (EMPs) as asbestiform based on morphologic features. Despite these caveats, it is clear that the criteria that we focused on, i.e., length of at least 10 microns and diameter less than 1 micron, are the best that we have for determining whether a particular EMP is likely asbestos as opposed to a cleavage fragment. Dr. Finkelstein points out that according to Harper et al., ‘a 1 μm width criteria is not being proposed here as a dividing line between safe and unsafe’. We are in agreement with this assessment. However, Dr. Finkelstein ignores the study we quoted by Berman and Crump indicating that fibers less than 10 μm in length are unlikely to be pathogenic. Because of the issues discussed in the papers by Harper et al. (2008) and Berman and Crump (2008), we believe it is prudent in any human lung tissue analysis for EMPs that the dimensions (width and length) of any EMP considered as possibly asbestiform be recorded. Finally, Dr. Finkelstein misrepresents our statement that ‘Our findings demonstrate that lack of pathogenicity of fibers less than 10 μm long or likelihood of cleavage fragments for fibers less than 10 μm long and greater than 1.0 μm in diameter has little or no effect on the classification of commercial amphibole fibers using our analytical methodology’. What was meant by this statement is that given published observations that fibers less than 10 μm long lack pathogenicity and that fibers less than 10 μm long and greater than 1.0 μm in diameter may be cleavage fragments, these observations have little or no effect on our classification of commercial amphibole fibers since only a small fraction of such fibers isolated from lung tissue samples were less than 10 μm long and greater than 1.0 μm in diameter. Although when taken out of context there was some ambiguity in our statement, for anyone who read the entire article (including the methodology) the meaning should have been clear. We apologize for any possible confusion.