Miracle-dz/UniFAR-FTUs huggingface dataset:
Estimating audiometric thresholds using simultaneous acquisition of ASSR and ABR from QASSR in patients with sensorineural hearing loss

Abstract Objectives: To evaluate the accuracy with which the innovative QASSR method predicts behavioral thresholds in adult patients with sensorineural hearing loss. Design: Subjects were tested at four carrier frequencies (500, 1000, 2000, and 4000 Hz). The resulting QASSR recordings were analyzed for thresholds and magnitude/phase characteristics. Tone-burst ABR was recovered from QASSR signal using CLAD method and analyzed in the time domain. The electrophysiological estimates were compared to hearing thresholds determined behaviorally. Study sample: Sixteen ears of nine volunteer subjects recruited from a clinical population. Results: All mean threshold estimates differed less than 3 dB for QASSR and less than 5 dB for ABR at 1000, 2000 and 4000Hz (carrier or pure-tone test frequencies). The largest differences were observed for both at 500 Hz (5.63 and 11.56 dB respectively). The audiometric configurations of QASSR and ABR estimates followed those of the respective behaviorally determined configurations across ears tested. Conclusions: QASSR method merges two dissimilar stimulation techniques, transient and steady-state, to create a hybrid stimulation-and-analysis paradigm that seems to improve the overall performance of the electrophysiological threshold estimation. The unique feature of the QASSR technique is the additional information afforded by the transient ABR, recovered from the same recording. The QASSR thus holds promise to be a very useful tool for practical clinical applications.
A pharmacotherapy algorithm for stabilization and maintenance of pediatric bipolar disorder.

OBJECTIVE To assess the feasibility and effectiveness of an evidence-based pharmacotherapy algorithm in the treatment of pediatric bipolar disorder. METHOD The study reports the results of a study of 64 bipolar type I subjects who were treated according to an algorithm developed in our specialty clinic. All subjects had been diagnosed using the Washington University in St. Louis Schedule for Affective Disorders and Schizophrenia. Subjects scored an average of 28 (+/- 4) on the baseline Young Mania Rating Scale. All subjects were assessed over an 18-month period. In addition, we were able to match 17 of the 64 subjects in the algorithm sample for gender, age, ethnicity, socioeconomic status, and diagnosis with an equal number of subjects in a psychopharmacology clinic who received treatment as usual. RESULTS Prescribing clinicians were able to implement primary and secondary strategies, including detailed tactics of medication choices in the algorithm group. Growth curve analysis of the total algorithm group showed strong and significant improvement in symptoms. Analyses of the matched groups also showed strong effects for the treatment algorithm over treatment as usual. Treatment adherence and family satisfaction were higher in the algorithm group. CONCLUSION An evidence-based, problem-solving pharmacotherapy algorithm is feasible and may be associated with better outcomes in the treatment of pediatric bipolar disorder. Randomized trials will be necessary to gather additional support for the algorithm's effectiveness.
End Stage Liver Disease Clinical Immune Tolerance in Liver Transplantation : Present and Future

Liver transplantation is the most effective treatment for endstage liver diseases with satisfactory clinical results. Unfortunately, adverse effects of life-long immunosuppression prevent the development of alternative strategies to achieve better long-term outcome. Achieving clinical operational tolerance is the ultimate goal in the clinical transplantation field. Around 15% of liver transplantation recipients develop spontaneous operational tolerance after immunosuppression withdrawal, and the percentage may be even higher in pediatric living donor liver transplantation recipients. Despite the progress, clinical operational tolerance is still rare in liver transplantation. Reprogramming the recipient immune system by creating chimerism and utilizing regulatory cell therapies are among the newer promising means to achieve clinical liver transplantation tolerance in the future. In this review, some proposed mechanism for clinical tolerance and current experimental trial will be introduced.
Ground-based high-resolution IR spectroscopy of Mars: H2O and H2O2 mapping, search for CH4, and determination of CO2 isotopic ratios

T. Encrenaz, B. Bezard, T. Greathouse, S. Holmes, M. Richter, D. Nuccitelli, J. Lacy, S. Lebonnois, F. Lefevre, S. Atreya, A. S. Wong, T. Owen, F. Forget 1 LESIA, Observatoire de Paris; 5, place Jules Janssen 92195 Meudon France 2 Lunar and Planetary Institute, 3600 Bay Area Bvd. , Houston TX 77058-1113, USA 3 Department of Astronomy, University of Texas at Austin, RLM 15.308, C-1400 Austin, TX 78712-1083, USA 4 Physics Department, University of California Davis, CA 95616, USA 5 Laboratoire de Meteorologie Dynamique, 5 place Jussieu 75231 Paris Cedex 05 6 Service d’Aeronomie, 5 place Jussieu, F-75231 Paris Cedex 05 7 Department of Atmospheric, Oceanic and Space Sciences, niversity of Michigan, Ann Arbor, MI 49109-2143, USA 8 Institute for Astronomy, University of Hawaii, Honolulu HI 96 122, USA
Childless Elders in Assisted Living: Findings from the Maryland Assisted Living Study

We compared data drawn from a random sample of 399 current assisted living residents and a subsample of 222 newly admitted residents for two groups: childless residents and residents with children. The percentage of childless residents (26%) in our study was slightly higher than U.S. population estimates of childless individuals aged 65 years and older (20%). In the overall sample, the two groups differed significantly by age, race, and women's years of education. The childless group was slightly younger, had a higher percentage of African American residents, and had more years of education than the group with children. In the subsample, we looked at demographic, functional, financial, and social characteristics and found that childless residents reported fewer diagnoses of dementia and fewer visits from a relative but more reported paying less money per month for assisted living and having private insurance than residents with children. As childlessness among older adults continues to increase, it will become increasingly important to understand how child status affects the need for and experience of long-term care.
Electricity, Highways and Manufacturing Growth: A Cost Based Estimate

This paper studies the rqle of electricity and highways on the Mexican manufacturing sector. The paper uses a weighted aggregate in put of labor and capital (with weights equal to their share in costs) and a weighted measure of infrastructure to estimate jointly the elasticity of infrastructure and the degree of internal returns to scale. 1 pool two digit industries to obtain the estimates for the whole manufacturing sec tor. This paper follows the first order tradition initiated by Solow (1957) and Hall (1988a, b). For the entire manufacturing sector, 1 find that a weighted average index of both types of infrastructure has a significant effect on manufacturing growth. At the sectoral level the evidence is mixed.
Identification of Tek/Tie2 Binding Partners

The Tek/Tie2 receptor tyrosine kinase plays a pivotal role in vascular and hematopoietic development. To study the signal transduction pathways that are mediated by this receptor, we have used the yeast two-hybrid system to identify signaling molecules that associate with the phosphorylated Tek receptor. Using this approach, we demonstrate that five molecules, Grb2, Grb7, Grb14, Shp2, and the p85 subunit of phosphatidylinositol 3-kinase can interact with Tek in a phosphotyrosine-dependent manner through their SH2 domains. Mapping of the binding sites of these molecules on Tek reveals the presence of a multisubstrate docking site in the carboxyl tail of Tek (Tyr1100). Mutation of this site abrogates binding of Grb2 and Grb7 to Tek in vivo, and this site is required for tyrosine phosphorylation of Grb7 and p85 in vivo. Furthermore, stimulation of Tek-expressing cells with Angiopoietin-1 results in phosphorylation of both Tek and p85 and in activation of endothelial cell migration and survival pathways that are dependent in part on phosphatidylinositol 3-kinase. Taken together, these results demonstrate that Angiopoietin-1-induced signaling from the Tek receptor is mediated by a multifunctional docking site that is responsible for activation of both cell migration and cell survival pathways.
Kinematic and dynamic models of hybrid robot manipulator for propeller grinding

In this article, we develop a hybrid robot manipulator for propeller grinding and derive its kinematic and dynamic models. The manipulator is constructed by combining a parallel mechanism and a serial one to increase high stiffness as well as workspace. Based on geometric constraints, inverse–direct kinematics and Jacobian are derived to be implemented in real time control. The velocity control is used to measure the surface of a propeller blade and the position control is conducted to grind the removal depth. The dynamic model, which is developed by a motor algebra, can compute the forces and moments acting at a passive joint and an active one. ©1999 John Wiley & Sons, Inc.
Genetic selection system for improving recombinant membrane protein expression in E. coli

A major barrier to the physical characterization and structure determination of membrane proteins is low yield in recombinant expression. To address this problem, we have designed a selection strategy to isolate mutant strains of Escherichia coli that improve the expression of a targeted membrane protein. In this method, the coding sequence of the membrane protein of interest is fused to a C‐terminal selectable marker, so that the production of the selectable marker and survival on selective media is linked to expression of the targeted membrane protein. Thus, mutant strains with improved expression properties can be directly selected. We also introduce a rapid method for curing isolated strains of the plasmids used during the selection process, in which the plasmids are removed by in vivo digestion with the homing endonuclease I‐CreI. We tested this selection system on a rhomboid family protein from Mycobacterium tuberculosis (Rv1337) and were able to isolate mutants, which we call EXP strains, with up to 75‐fold increased expression. The EXP strains also improve the expression of other membrane proteins that were not the target of selection, in one case roughly 90‐fold.
Ensemble of Neural Networks for Multi-label Document Classification

This paper deals with multi-label document classification using an ensemble of neural networks. The assumption is that different network types can keep complementary information and that the combination of more neural classifiers will bring higher accuracy. We verify this hypothesis by an error analysis of the individual networks. One contribution of this work is thus evaluation of several network combinations that improve performance over one single network. Another contribution is a detailed analysis of the achieved results and a proposition of possible directions of further improvement. We evaluate the approaches on a Czech ČTK corpus and also compare the results with state-of-the-art approaches on the English Reuters-21578 dataset. We show that the ensemble of neural classifiers achieves competitive results using only very simple features.
Modeling the effects of an individual SRR by equivalent circuit method

This paper proposes a novel theoretical equivalent circuit model to characterize the split ring resonator (SRR), based on the analysis of the individual SRR geometry configuration and the distribution relationship of the electric charge and electric current in it. Then the telegrapher equations are obtained to develop the constitutive relations applying transmission line theory. Numerical simulations are used to validate the equivalent circuit model, and the results obtained by the equivalent circuit model are in good agreement with the present method
The role of medical comorbidity in outcome of major depression in primary care: the PROSPECT study.

OBJECTIVE The authors described the influence of specific medical conditions on clinical remission and response of major depression (MDD) in a clinical trial evaluating a care-management intervention among older primary-care patients. METHODS Adults age 60 years and older were randomly selected and screened for depression. Participants were randomly assigned to Usual Care or to an Intervention with a depression care-manager offering algorithm-based care for MDD. In all, 324 adults meeting criteria for MDD were included in these analyses. Remission and response was defined by a score on the Hamilton Rating Scale for Depression <10 and by a decrease from baseline of > or =50%, respectively. Medical comorbidity was ascertained through self-report. Cognitive impairment was defined by a score <24 on the Mini-Mental State Exam (MMSE). RESULTS In Usual Care, rates of remission were faster in persons who reported atrial fibrillation (AF) than in persons who did not report AF and slower in persons who reported chronic pulmonary disease than in persons who did not report chronic pulmonary disease; rates of response were less stable in persons with MMSE <24 than in those with MMSE > or =24. In the Intervention condition, none of the specific chronic medical conditions were significantly associated with outcomes for MDD. CONCLUSIONS Because disease-specific findings were observed in persons who received Usual Care but not in persons who received more intensive treatment in the Intervention condition, our results suggest that the association of medical comorbidity and treatment outcomes for MDD may be determined by the intensity of treatment for depression.
Isolated ACTH deficiency presenting as severe hypercalcaemia

© 2007 The Authors Journal compilation © 2007 Blackwell Publishing Ltd, Clinical Endocrinology , 66 , 602–605 of aldosterone to its usual trophins. The complete loss of aldosterone production seen in examples of gross 11 β -hydroxylase deficiency is probably secondary to the marked over production of deoxycorticosterone that leads to independent mineralocorticoid action of this hormone with secondary suppression of the renin/angiotensin/ aldosterone axis. In conclusion, we describe a novel splice-site mutation in CYP11B1 that results in partial 11 β -hydroxylase deficiency manifested as XX masculinization when combined with the Q356X mutation.
AN APPLICATION OF THE FINITE VOLUME METHOD TO THE BIO-HEAT-TRANSFER-EQUATION IN PREMATURE INFANTS

Abstract. In this report the development of a finite volume method for th e time-accurate simulation of the temperature distribution in a premature infant inside an in cubator or in an open radiant warmer is described. The real geometry of a premature infant is obtained from MRT-ima ges. The infants thermoregulation is modelled by the so-called bio-heat-transfer-equation incorporating source terms and Neumann boundary conditions. The source terms describe the metabolic heat production, the blood flow and the respiratorical water loss whereas the Neumann boundary conditions model the heat transfer by transepider mal water loss, radiation, convection and conduction. The numerical solution is carried out by the developed finite vol ume method whose spatial discretization is done by a 3D-mesh-generator from CFD. For the time integration a semi -implicit multistep method is used. The arising large, sparse linear systems are efficiently solved with a Krylov su bspace method. Some successful test runs using real life data are presented.
Different Nebulized Budesonide Dosing Regimens in a Mouse Model of Chronic Asthma

Meandros Medical Journal 2016;17:138-45 Ad dress for Cor res pon den ce/Ya zış ma Ad re si: Pınar Uysal MD, Adnan Menderes University Faculty of Medicine, Pediatric Allergy and Clinical Immunology, Aydın, Turkey Phone : +90 444 1 256 E-mail : druysal.pinar@gmail.com doi:10.4274/meandros.2798 Received/Geliş Ta rihi : 05.04. 2016 Accepted/Ka bul Ta ri hi : 11.04. 2016 Anah tar Ke li me ler Astım, budezonid, tedavi, akciğer, kemik, fare
CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain

The CD11c enhanced yellow fluorescent protein (EYFP) transgenic mouse was constructed to identify dendritic cells in the periphery (Lindquist et al. [ 2004 ] Nat. Immunol. 5:1243–1250). In this study, we used this mouse to characterize dendritic cells within the CNS. Our anatomic results showed discrete populations of EYFP+ brain dendritic cells (EYFP+ bDC) that colocalized with a small fraction of microglia immunoreactive for Mac‐1, Iba‐1, CD45, and F4/80 but not for NeuN, Dcx, NG2 proteoglycan, or GFAP. EYFP+ bDC, isolated by fluorescent activated cell sorting (FACS), expressed mRNA for the Itgax (CD11c) gene, whereas FACS anlaysis of EYFP+ bDC cultures revealed the presence of CD11c protein. Light microscopy studies revealed that EYFP+ bDC were present in the embryonic CNS when the blood–brain barrier is formed and postnatally when brain cells are amenable to culturing. In adult male mice, EYFP+ bDC distribution was prominent within regions of the CNS that 1) are subject to structural plasticity and neurogenesis, 2) receive sensory and humoral input from the external environment, and 3) lack a blood–brain barrier. Ultrastructural analysis of EYFP+ bDC in adult neurogenic niches showed their proximity to developing neurons and a morphology characteristic of immune/microglia cells. Kainic acid‐induced seizures revealed that EYFP+ bDC responded to damage of the hippocampus and displayed morphologies similar to those described for seizure‐activated EGFP+ microglia in the hippocampus of cfms (CSF‐1R) EGFP mice. Collectively, these findings suggest a new member of the dendritic cell family residing among the heterogeneous microglia population. J. Comp. Neurol. 508:687–710, 2008. © 2008 Wiley‐Liss, Inc.
Care workers’ voices in designing assistive technologies for preventing malnutrition in older people with dementia: Innovative Practice

Technology may be considered a way to promote nutritional health in people with dementia living in their home. For technologies to be effective and accepted by users, understanding technological needs prior to technology development is crucial; however, this necessitates greater research investment. Consequently, our focus is to derive needs for nutritional health promoting technologies for older people with dementia by understanding perceptions of care workers recruited by the aged care industry. In this paper, we provide a brief description of the theoretical framework that underpins the research study and the research methods selected. Significant learning outcomes related to the research methods include managing hierarchical relationships among participants, engagement with the care workers working in the community and using external material to spark discussion.
Changes in blood pressure, blood flow towards the head and heart rate during 90 deg head‐up tilting for 30 min in anaesthetized male rats

What is the central question of this study? How does the baroreceptor reflex contribute to systemic blood pressure (BP) control during prolonged 90 deg head‐up tilting (HUT) in unconscious rats? What is the main finding and its importance? In intact rats, heart rate (HR) increased after the transition to upright by HUT, and BP was maintained in this posture throughout the 30 min experimental period. After sinoaortic denervation, which results in lack of discharge of the baroreflex afferents, HR and BP decreased gradually during 30 min of 90 deg HUT, suggesting that the baroreceptor reflex is an important factor for maintenance of BP during long‐term upright posture.
Cognizers - neural networks and machines that think

Edge of the Frontier: Computer Science Needs a Unifying Theory. The Seceret of Life: Learning from Frankenstein's Mistakes. Sensation: The Mind is Not All in the Brain. The Necessary Insight: Fathering the Cognizer Revolution. Learning to Learn: Last Piece to the Brain's Puzzle. Neural Circuitry: Forerunners of the Cognizer. Fledgling Cognizers: Need a Computer or a Cognizer? Cognizers of the Mind: If Their Bodies are Perfected, Will They Have Minds? Biotechnology Unleashed: Machines Modeled after Man. Epilogue. Select Bibliography. Index.
Winter dysentery in dairy herds: electron microscopic and serological evidence for an association with coronavirus infection

Faeces and, or, paired sera were collected from cows in six dairy herds with classical winter dysentery. Similar samples were collected from cows in three other dairy herds experiencing non-haemorrhagic diarrhoea during the survey period. Coronavirus was the only enteric pathogen identified by immune electron microscopy (IEM) in all six outbreaks, occurring in 26 of 29 (90 per cent) of the affected cows and in one of 11 normal cows from the same herds. Nineteen of 26 affected cows (73 per cent) developed greater than four-fold increases in neutralising antibody titres to the Mebus strain of bovine coronavirus, compared with two of eight normal cows in the same herds. No cows showed greater than four-fold increases in antibody titres to bovine virus diarrhoea virus. None of the cows from the three herds with non-haemorrhagic diarrhoea shed coronavirus in faeces detectable by IEM or developed greater than two-fold rises in coronavirus antibody titres in paired sera. No enteric pathogens were identified in two of the herds. However, two cows in the third herd shed a group B rotavirus detected by IEM. These findings provide additional evidence for a possible role for bovine coronavirus in the aetiology of winter dysentery. Furthermore, this is the first report of a group B rotavirus associated with diarrhoea in adult cattle.
Host-based Implementation of NICE-A in Cloud Computing's Virtual Network

To ride the tide of change which is inevitable, innovations are necessary. By using the concept of virtualization most of enterprises are trying to reduce their computing cost. This demand of reducing the computing cost has led to the innovation of Cloud Computing. Nowadays organizations recognized cloud for it different attractive property such as economically attractive and use it to host their services. So that their services available easily and economically to their users. But also many organization put security in their top concern before adopting the cloud service. One of the most significant problem that associated with cloud computing is cloud security that drawn a lot of analysis and research within past few years. Inside the cloud system, especially the Infrastructure-as-a-Service (IaaS) clouds, the actual prognosis associated with zombie exploration problems is exceedingly hard. This is because cloud users might deploy somewhat insecure purposes on the exclusive products. NICE is a Network Intrusion detection and Countermeasure selection in virtual network systems (NICE) design to establish an intrusion detection framework which is defense-in-depth in nature. Into the intrusion detection processes an attack graph analytical procedures is incorporated by NICE for better attack detection. In this paper we proposed to implement NICE-A as a host based agent instead network based so the data delivery time between sender and intended destination is saved as NICE-A is implemented in destination (which is cloud server in our case) and for large amount of data this definitely shows improvement in computation time. Moreover as NICE-A is implemented as host based so CPU utilization is also improved.