Miracle-dz/UniFAR-FTUs huggingface dataset:
DMD052563 1662..1670

Despite increasing recognition of potential untoward interactions between herbal products and conventional medications, a standard system for prospective assessment of these interactions remains elusive. This information gap was addressed by evaluating the drug interaction liability of the model herbal product milk thistle (Silybum marianum) with the CYP3A probe substrate midazolam. The inhibitory effects of commercially available milk thistle extracts and isolated constituents on midazolam 19-hydroxylation were screened using human liver and intestinal microsomes. Relative to vehicle, the extract silymarin and constituents silybin A, isosilybin A, isosilybin B, and silychristin at 100 mM demonstrated >50% inhibition of CYP3A activity with at least one microsomal preparation, prompting IC50 determination. The IC50s for isosilybin B and silychristin were ∼60 and 90 mM, respectively, whereas those for the remaining constituents were >100 mM. Extracts and constituents that contained the 1,4-dioxane moiety demonstrated a >1.5-fold shift in IC50 when tested as potential mechanism-based inhibitors. The semipurified extract, silibinin, and the two associated constituents (silybin A and silybin B) demonstrated mechanism-based inhibition of recombinant CYP3A4 (KI, ∼100 mM; kinact, ∼0.20 min) but not microsomal CYP3A activity. The maximum predicted increases in midazolam area under the curve using the static mechanistic equation and recombinant CYP3A4 data were 1.75-fold, which may necessitate clinical assessment. Evaluation of the interaction liability of single herbal product constituents, in addition to commercially available extracts, will enable elucidation of mechanisms underlying potential clinically significant herb-drug interactions. Application of this framework to other herbal products would permit predictions of herb-drug interactions and assist in prioritizing clinical evaluation.
Development of a micro-blood-typing system using micro-stereolithography technology

ABO typing is the first test done on blood used for transfusion. A person must receive ABO-matched blood, as ABO incompatibility is the major cause of fatal transfusion reactions. Until now, this blood typing has been done manually. There is a need for an automated typing machine that uses a very small volume of blood. In this paper, we present a new micro-blood-typing system with a fully 3-dimensional geometry, which was realized using micro-stereolithography. This system was fabricated using a novel integration process based on a virtual environment, and blood-typing experiments using this system were successfully performed.
PLANTATION HISTORY AND GROWTH OF OLD PINE STANDS IN KATHMANDU VALLEY: A DENDROCHRONOLOGICAL APPROACH

Pinus roxburghii Sarz. makes sub-tropical dry forest in the Himalaya and considered a potential species for dendrochronological studies. In Kathmandu valley, its distribution seems to be fluctuating from historical time. This study was carried out to disclose the plantation history of P. roxburghii inside Kathmandu valley as well as to extend understanding of its diameter, age and growth rate relationships. Tree core samples were collected from four locations in Kathmandu and one in Bhaktapur. The plantation history of Sallaghari (Bhaktapur), Singha Durbar Baraf Bag and Kumari temple, Thapathali (Kathmandu) was determined around 1870 AD, 1900AD and1875AD, respectively. The radial increment rate of this tree at Sallaghari (Bhaktapur) was 0.25±0.05cm/yr, Singh Durbar was 0.31±0.08 cm/yr, and Kumari temple was 0.32 ±0.03 cm/yr. The tree growth noticeably varied with location and topo-climatic conditions. Therefore, it is suggested that site selection is crucial for the suitability of this species to dendroclimatic study.
S PEECH P ERCEPTION AND T HE R OLE OF S EMANTIC R ICHNESS IN P ROCESSING

Semantic richness is ordinarily defined as a construct encompassing indicators of variability in a given word’s meaning. Higher semantic richness has consistently been connected to facilitation in processing, at least when recognition tasks are used [1]. These findings, however, have come largely from studies based on visual word recognition, and related studies focusing on the acoustic signal and speech perception are less common. Effects observed may vary across modalities, as is exemplified in the opposite effect of phonological neighborhood density when the visual and the auditory lexical decision tasks are compared [2]. Furthermore, models of spoken word recognition tend to focus on the activationcompetition process concerning some representation of the acoustic input [3], and disregard how the activation of networks of meaning based on that very acoustic input shapes competition and facilitates or inhibits speech perception. In other words, very little is known about how semantic richness interacts with perception of the acoustic, speech signal. One study that investigated the effects related to a multitude of semantic variables in the auditory modality was conducted by Goh et al. [4]. They found linear effects of concreteness and the number of semantic features and a quadratic effect of valence — all of which facilitated spoken word recognition in the auditory lexical decision task. Arousal, semantic neighborhood density, and semantic diversity had no effect. However, stimuli used by Goh et al. were a limited set of under 500 words, most of which were concrete nouns. The goal of the present study is to expand the scope of the analysis to a larger number of words by using the data collected in the Massive Auditory Lexical Decision (MALD) project [2] and to further explore semantic richness effects as they may pertain to the perception and processing of spoken language.
AUTOMOBILE EXTERIOR DESIGN MODEL: FRAMEWORK DEVELOPMENT AND SUPPORING CASE STUDIES

As customer values become increasingly diverse, automobile exterior design is becoming one of the most critical elements influencing customer purchase behavior for automakers. The author develops a scientific approach to identifying customers’ tastes, called “Automobile Exterior Design Model” (AEDM). To address this issue, the author uses “Customer Science Principle aiming to achieve Intelligence Design Concept Method” (CS-IDCM) developed elsewhere. AEDM improves the design business process so that implicit knowledge on customer is turned into explicit knowledge. In order to strengthen automobile exterior design, AEDM contributes to the following; (A) Improvement of Design Business Process Methods for Automobile Profile Design, (B) Creation of Automobile Profile Design using “Psychographics” Approach Methods, and (C) Actual studies on Automobile Profile Design, Form and Color Matching Methods. The validity of the proposed model was verified through case studies of the actual application of AEDM.
Mobile Edge Computing versus Fog Computing in Internet of Vehicles

—Vehicular networks and the recent Internet of Vehicles (IoV) are continuously developing, aiming to solve the current and novel challenging needs in the domain of transportation systems. Edge computing offers a natural support for Internet of Vehicles, supporting fast response, context awareness, and minimization of the data transfer to the centralized data centers - all these being allowed by the edge computing availability close to mobile vehicles. Multi-access (Mobile) Edge Computing, fog computing, cloudlets, etc., are such candidates to support IoV; their architectures and technologies have overlapping characteristics but also differences in approach. A full convergence between them has not yet been achieved. Also, it is still not completely clarified which solution could be the best trade-off to be adopted in the Internet of vehicles context and for which use cases. This paper is not a complete survey, but attempts a preliminary evaluation of some of the currently proposed Mobile Edge Computing and fog computing solutions for vehicular networks.
Prognostic analysis of CD5 expression in double-hit diffuse large B-cell lymphoma and effectiveness comparison in patients treated with dose-adjusted EPOCH plus rituximab/R-CHOP regimens Blood and Lymphatic Cancer: Targets and Therapy

Objectives: To compare the ef ﬁ cacy of rituximab, dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin (DA-EPOCH-R) with traditional rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) regimens in CD5+ double-hit lymphoma (DHL) and to evaluate prognostic factors. Methods: We retrospectively studied 139 patients with newly diagnosed DHL/THL diffuse large B-cell lymphoma (including 20 cases CD5+ and 119 cases CD5 − ), 87 cases were MYC/BCL2 DHL, 30 cases were MYC/BCL6 DHL, 22 cases were THL. MYC, BCL2 and BCL6 rearrangements were examined by ﬂ uorescence in-situ hybridization. CD5 is detected by immunohistochemistry (IHC). Results: The objective response rate (ORR) difference between CD5+ and CD5 − was signi ﬁ cant (80.0% vs 63.8%, P =0.003). The median follow-up time was 18 months (range: 4 – 39 months). Progression-free survival (PFS) of CD5+ group was signi ﬁ cantly worse than that of CD5- (28.1% vs 59.0%, P =0.028), while no signi ﬁ cant difference was observed in overall survival (OS) (32.1% vs 59.9%, P =0.057). Compared with the two regimens, the 2-year survival rate of DA-EPOCH-R group was signi ﬁ cantly superior than that of R-CHOP (63.6% vs 45.4%, P =0.034 for PFS; 67.4% vs 47.8%, P =0.038 for OS). Besides, CD5+ patients receiving DA-EPOCH-R had survival bene ﬁ ts compared with R-CHOP in PFS (85.7% vs 23.0%, P =0.029), but there was no statistical difference in OS (87.7% vs 34.4.0%, P =0.064). However, in DA-EPOCH-R protocol, there was no signi ﬁ cant difference between CD5+ DHL (MYC/BCl2 and MYC/BCL6) and triple-hit lymphoma ( P =0.776 for PFS; P =0.728 for OS). Multivariate analysis showed that CD5+ treatment regimen and disease stage were independent prognostic factors. Conclusion: Our retrospective study shows that CD5+ has a poorer prognosis than CD5 − patients. Based on its improved lifetime and good tolerance on CD5+ patients, which is expected to become the ﬁ rst-line treatment for high-risk DLBCL types based on more clinical research. PD, progressive disease; ORR, overall response rate. vincristine, cyclopho- sphamide, doxorubicin.
Investigation of common genes for metabolic disorders: A bioinformatics approach

The failure of metabolism process is resulted by metabolic disorder and growing interest worldwide. The purpose of this research is to investigate common genes that are shared by four metabolic diseases like OB, T2D, HT and CVD. Associated genes with specific metabolic disease have been accumulated from different world recognize databases. Initially 2794, 1520, 2531 and 4713 genes are collected respectively. Collected genes are verified and mined for the establishment of gene interaction models. It reduced 91.05%, 89.74%, 92.70% and 96.22% genes respectively. Sorting technique has been applied for arranging the collected genes separately. After completion of analysis 125, 108, 121 and 110 genes have been achieved respectively. 62 common candidate genes are determined. Finally, cross linkage process discovered 10 common genes and reduced 83.87% genes for four diseases. This research will be helpful not only to construct simple common metabolic pathway but also to target drug for metabolic diseases.
Various Types of Tool for Instrumentation of Android Application

- There are various types of tool for instrumenting the android application. PIN is a dynamic binary instrumentation engine or framework. It can be used for several purposes, but mostly for program analysis (memory allocation analysis, error detection, performance profiling, etc.) and for architectural study (processor and cache simulation, trace collection, etc…). There are three type of tools (1) Pintool (2) Soot (3) Drozer. Pintool is mostly use for Program analysis. Drozer tool is used for security assessment and soot tool are used for optimization. This paper analyze these tool and pin tool is best for instrumenting the android application
Steady state and transient simulation for electricity-gas integrated energy systems by using convex optimisation

The increasing interdependence between electric power and natural-gas systems requires integrated simulation tools applicable to the coupled system. Therefore, this study proposes steady-state and transient simulation tools for electricity-gas integrated energy systems (IESs) by using convex optimisation. Steady-state IES simulation is designed for long-term planning studies while transient IES simulation, which includes line-pack storage, is designed for real-time operational research. The proposed convex steady-state gas flow model introduces binary variables to represent gas flow directions, and employs the second-order cone (SOC) to relax non-convex pipeline gas flow equations. As a result, steady-state gas flow analysis is formulated as a mixed integer SOC programming problem. The proposed transient gas flow model employs the implicit finite difference method to transform partial differential equations into algebraic difference equations. Moreover, the short-term gas flow directions are specified and SOC relaxations are used. Simulation results on an integrated IEEE 24-node system and Belgian 20-node gas system verify the effectiveness of the proposed SOC models. The impacts of wind power forecast errors on multi-period gas network operations are also investigated.
Cloning and Characterization of the Abscisic Acid-Specific Glucosyltransferase Gene from Adzuki Bean Seedlings

The glycosylated forms of abscisic acid (ABA) have been identified from many plant species and are known to be the forms of ABA-catabolism, although their (physiological) roles have not yet been elucidated. ABA-glucosyltransferase (-GTase) is thought to play a key role in the glycosylation of ABA. We isolated an ABA-inducible GTase gene from UDP-GTase homologs obtained from adzuki bean (Vigna angularis) seedlings. The deduced amino acid sequence (accession no. AB065190) showed 30% to 44% identity with the known UDP-GTase homologs. The recombinant protein with a glutathione S-transferase-tag was expressed in Escherichia coli and showed enzymatic activity in an ABA-specific manner. The enzymatic activity was detected over a wide pH range from 5.0 to 9.0, the optimum range being between pH 6.0 and 7.3, in a citrate and Tris-HCl buffer. The product from racemic ABA and UDP-d-glucose was identified to be ABA-GE by gas chromatography/mass spectrometry. The recombinant GTase (rAOG) converted 2-trans-( )-ABA better than ( )-S-ABA and ( )-RABA. Although trans-cinnamic acid was slightly converted to its conjugate by the GTase, ( )-PA was not at all. The mRNA level was increased by ABA application or by water stress and wounding. We suggest that the gene encodes an ABA-specific GTase and that its expression is regulated by environmental stress.
Challenges to Enhancing Web Accessibility in Saudi University Websites: An Exploratory Study

—This paper aims to provide an exploratory study of challenges in enhancing web accessibility faced by web developers of the Arabic language version of university websites in Saudi Arabia. The number of challenges encountered were wide ranging from a lack of accessibility knowledge and negative attitude upon disability issues. In the light of the study findings, this paper presents some recommendations for improving the accessibility status in Saudi university websites.
An Analysis of Problem Solving Ability using mathematical modeling strategies in Brain-Based Learning

Problem-solving ability learning (PSA) is a fundamental problem that needs to be developed in learning mathematics at school. In this research mathematical modeling strategies (MMS) are developed for problem solving. This study aims to investigate how the implementation of MMS for problem-solving in mathematics learning. This study was conducted at SMP Negeri 34 Semarang. This research used sequential explanatory design. The quantitative research design is a quasi experimental design with the nonequivalent posttest-only control group design. Data collection techniques used in this study are documentation, tests, scale, interview, and observation, then processed with a classical completeness test, t-test, and proportion test. The results of this study indicate that (1) PSA on the application of mathematical modelling strategies on Brain-Based Learning (BBL) has achieved classical mastery learning; (2) the PSA of the experimental class by applying mathematical modeling strategies to Brain-Based Learning is better than the control class that uses the Problem Based Learning; and (3) two subjects with high category self-efficacy (SE) have high PSA, two SE subjects are categorized having middle PSA, and two low SE subjects have a low PSA.
Malignancy-Associated Vessel Tortuosity: A Computer-Assisted, MRA Study of Choroid Plexus Carcinoma in Genetically Engineered Mice

Background and Purpose—The ability to assess tumor malignancy and to monitor treatment response non-invasively would be of value to both clinicians and animal investigators. This report describes the MR imaging characteristics of a genetically engineered mouse model of choroid plexus carcinoma (CPC) during tumor growth and progression to malignancy. We assess the ability of vessel tortuosity measurements, as calculated from high-resolution MRA images, to detect emerging CPC cancers. Methods—MR images were analyzed of 9 healthy mice and of 20 CPC mice with precancerous choroid dysplasia or with cancer over a wide range of sizes. Two vessel tortuosity measures and a measure of vessel density (vessel count) were calculated from MRA images. Malignancy assessment was based upon a statistical analysis of vessel tortuosity, using an equation derived from an earlier study of human brain tumor patients. Results—Choroid dysplasia was correctly judged non-malignant. On the basis of vessel count, neoangiogenesis could not be detected until cancers were full-blown and had reached a volume of approximately 80mm3. Vessel tortuosity measurements, however, correctly identified emerging malignancy in lesions larger than 0.3mm3. Conclusion—This report provides the first description of in vivo, MR imaging characteristics of genetically engineered CPC mice during the progression from dysplasia to cancer. Vessel tortuosity measurements offer promise of correctly defining even tiny tumors as malignant.
Soil organic matter build-up during soil formation in glacier forelands 2 around the world 3

3 Khedim Norine 1,2, Cécillon Lauric 3,4, Poulenard Jérôme 1, Barré Pierre 4, Baudin François 5, Marta 4 Silvio 6, Rabatel Antoine 7, Dentant Cédric 13, Cauvy-Fraunié Sophie 9, Anthelme Fabien 12, Gielly 5 Ludovic 2, Ambrosini Roberto 6, Franzetti Andrea 8, Azzoni Roberto Sergio 6, Caccianniga Marco 6 Stefano 14, Compostella Chiara 15, Clague John 16, Tielidze Levan 10,11, Messager Erwan 1, Choler 7 Philippe 2, Ficetola Francesco 2,6
University of Birmingham Ultra-wide patch antenna array design at 60GHz band for remote vital sign monitoring with doppler radar principle

In this paper, ultra-wide patch antenna arrays have been presented at 60 GHz band (57.24 – 65.88 GHz) with improved gain and beam-width capabilities for remote detection of respiration and heart beat rate of a person with Doppler radar principle. The antennas measured and simulation results showed close agreement. The breathing rate (BR) and heart rate (HR) of a 31-year-old man have been accurately detected from various distances ranging from 5 to 200 cm with both single-antenna and dual-antenna operations. In the case of single-antenna operation, the signal is transmitted and received with the same antenna, whereas in dual-antenna operation, two identical antennas are employed, one for signal transmission and the other for reception. It has been found that in case of the single-antenna operation, the accuracy of the remote vital sign monitoring (RVSM) is good for short distance; however, in the case of the dual-antenna operations, the RVSM can be accurately carried out at relatively much longer distance. On the other hand, it has also been seen that the visual results are more obvious with higher gain antennas when the radar beam is confined just on the subject ’ s body area.
Title : In vivo multiphoton microscopy imaging of melasma

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/pcmr.12756 This article is protected by copyright. All rights reserved. MR. GRIFFIN LENTSCH (Orcid ID : 0000-0003-2465-9937) DR. ANAND GANESAN (Orcid ID : 0000-0003-4944-9274)
COPD_A_314849 2291..2299

1Makerere University Lung Institute, Kampala, Uganda; 2Department of Respiratory Sciences, University of Leicester, Leicester, UK; 3Centre for Exercise and Rehabilitation Science (CERS), NIHR Leicester Biomedical Research Centre – Respiratory, University Hospitals of Leicester NHS Trust Leicester, Leicester, UK; 4Department of Physiotherapy, Mulago Hospital, Kampala, Uganda; 5Physiology Department, College of Health Sciences, Makerere University, Kampala, Uganda; 6University of Plymouth, Plymouth, UK Introduction: Pulmonary rehabilitation (PR) is a low cost, high impact intervention that ameliorates the disability associated with chronic respiratory diseases (CRD). PR is becoming increasingly recognized in low resource settings where the burden of CRD is rapidly increasing. To aid the implementation of PR in Uganda, we conducted a study to assess the attitudes and opinions towards PR among patients with CRD in Uganda and explore barriers faced by health care workers (HCWs) in referring to PR. Methods: A cross-sectional study comprising two survey populations: people living with CRD and HCWs regarded as potential PR referrers and PR deliverers. This exploratory study sought initial opinions and thoughts regarding PR, as well as baseline knowledge and potential barriers faced in the referral process. Results: Overall, 30 HCWs (53% female, 43% doctors) and 51 adults with CRD (63% female) participated in the survey. Among those with CRD, the majority reported breathlessness as a major problem (86%) and breathlessness affected their ability to do paid and unpaid work (70%). Interest in PR was high amongst adults with CRD (92%) with preference for a hospital-based programme (67%) as opposed to community-based (16%) or home-based (17%). All HCWs considered PR important in lung disease management, but 77% do not refer patients due to a lack of information about PR. HCWs’ free-text responses identified the need for training in PR, patient education and streamlining the referral process as key elements to develop successful PR referral services. Conclusion: To successfully set up a PR service for people with CRD in Uganda, there is a great need for appropriately tailored training and education of prospective referrers about CRD and PR programs. Educating patients about the benefits of PR as well as streamlining the referral process is critical in expanding PR services across Uganda to fulfill this unmet need.
HEMATOPOIESIS AND STEM CELLS Lin Fc « RI 1 cells in human blood constitute a rare population of mast cell progenitors

we propose that the Lin 2 CD34 hi CD117 int/hi Fc « RI 1 blood cells are closely related to human tissue mast cells and likely constitute an immediate precursor population, which can give rise to predominantly mast cells. Furthermore, asthmatics with reduced lung function had a higher frequency of Lin 2 CD34 hi CD117 int/hi Fc « RI 1 blood mast cell progenitors than asthmatics with normal lung function. ( Blood . 2016;127(4):383-391)
AGI June 39/6

TONY W. H. LI,1 JIAFANG WANG,1 JASON T. LAM,2 EDGAR M. GUTIERREZ,1 R. SERGIO SOLORZANO-VARGUS,3 HUGH V. TSAI,1 AND MARTÍN G. MARTÍN1 1Department of Pediatrics, Division of Gastroenterology and Nutrition, and 2Department of Physiology, University of California Los Angeles School of Medicine, Los Angeles 90095-1752; and 3Department of Biology, California State University, Northridge, California 91330