Miracle-dz/UniFAR-FTUs huggingface dataset:
C-reactive Protein Levels in Generalized Aggressive Periodontitis Patients

C-REACTIVE PROTEIN LEVELS IN GENERALIZED AGGRESSIVE PERIODONTITIS PATIENTS Trang N. Salzberg,* Jeffrey D. Rogers, David M. Abbott, Joseph V. Califano, Alvin M. Best, d Harvey A. Schenkein, e Background: There is mounting evidence to indicate that periodontitis may be a risk factor for cardiovascular disease (CVD). Periodontitis may be linked to CVD as either an etiologic mechanism or a predisposing factor that can hasten disease progression. Proinflammatory cytokines, elevated fibrinogen, and platelet aggregation are all potential mechanisms. The purpose of this study is to compare and review the serological differences in subjects with severe periodontitis, some of which involve established risk factors for atherosclerosis, particularly heightened C-reactive protein levels. Methods: A total of 184 subjects, comprising of two periodontal subgroups, nonperiodontal (NP = 91) and generalized aggressive periodontitis (SP = 93), had serum evaluated for C-reactive protein (CRP) levels using a high sensitive ELISA test. The CRP levels were compared against clinical and demographical data to include race, age, gender, number of teeth, probing depth, attachment level, bleeding index, plaque index,
Total Quality Management in Pathological Laboratories: An Overview with Emphasis on Need for Structured National Policy

The last decade has witnessed tremendous growth in healthcare sector. Pathological laboratories plays central role in decision making of clinicians to start proper procedure to cure disease or abnormality in patient. Continuous Total Quality management practice in pathological laboratories is mandatorily to be adopted in order to deliver error free services. It cannot be achieved simply through the control of accuracy in analytical testing phase alone. In analysis of Clinical specimen there are many possible pre analytical errors also. The quality system for pathological laboratories must include promotion of accuracy in analytical phase as well as quality assurance in the reliability of pre analytical and post analytical activities. Active monitoring and feedback control of all potential defects generated by laboratory personnel as well as non laboratory personnel is necessary part of quality improvement. In present study authors strongly recommends that Pathological laboratories should strive to produce high quality result to its customers by utilizing up to date scientifically proved methodology employing competent staff, monitoring process to control internal and external quality control and participation in external quality assurance assessment schemes.
Financial Liberalization and the Changing Characteristics of Nordic Stock Returns

This paper uses a multivariate regime-switching framework to investigate and endogenously date changes in return characteristics on the four largest Nordic stock markets. We find that the deregulated time-period, specifically after 1982, is associated with higher expected return, higher volatility, stronger links with international stock markets and higher correlation between the Nordic stock markets. This higher correlation is mainly driven by common higher correlation with international stock returns and not by higher correlation between country specific components of return. Further, our evidence support the argument that market liberalization creates excess volatility but also that Nordic investors are more than compensated for this by higher expected returns and the opportunity to cross-border diversification after liberalization.
Impact of graphene oxide on human placental trophoblast viability, functionality and barrier integrity

Graphene oxide (GO) is considered a promising 2D material for biomedical applications. However, the biological health effects of GO are not yet fully understood, in particular for highly sensitive populations such as pregnant women and their unborn children. Especially the potential impact of GO on the human placenta, a transient and multifunctional organ that enables successful pregnancy, has not been investigated yet. Here we performed a mechanistic in vitro study on the placental uptake and biological effects of four non-labelled GO with varying physicochemical properties using the human trophoblast cell line BeWo. No overt cytotoxicity was observed for all GO materials after 48 h of exposure at concentrations up to 40 µg ml−1. However, exposure to GO materials induced a slight decrease in mitochondrial activity and human choriogonadotropin secretion. In addition, GO induced a transient opening of the trophoblast barrier as evidenced by a temporary increase in the translocation of sodium fluorescein, a marker molecule for passive transport. Evidence for cellular uptake of GO was found by transmission electron microscopy analysis, revealing uptake of even large micro-sized GO by BeWo cells. Although GO did not elicit major acute adverse effects on BeWo trophoblast cells, the pronounced cellular internalization as well as the potential adverse effects on hormone release and barrier integrity warrants further studies on the long-term consequences of GO on placental functionality in order to understand potential embryo-fetotoxic risks.
Implementing CDS Hooks Communication in an Arden-Syntax-Based Clinical Decision Support Platform

INTRODUCTION Arden Syntax is a Health Level Seven International standard for the development of clinical decision support (CDS) solutions. CDS Hooks is a specification for an interface to call CDS services from an electronic health record. Implementing the CDS Hooks interface into ArdenSuite, an Arden-Syntax-based CDS platform, will further enhance its interoperability with external systems. METHODS The development of this interface consisted of three parts: (1) The RESTful interface defined by CDS Hooks had to be implemented; this included the support of specifically formatted data for the input and output of the CDS functions. (2) The existing FHIR connector had to be adjusted. In CDS Hooks, a FHIR server can be defined for each CDS service call individually. In the current version of the connector, a FHIR server has to be configured in advance to call the CDS service. (3) Additional data points that did not exist previously, such as a description or hook for each CDS service, had to be collected and saved. RESULTS Basic support of the CDS Hooks API was established in the ArdenSuite and tested. The FHIR connector was adapted. DISCUSSION The missing parts for full CDS Hooks support were implemented. As a use case, we employed Hepaxpert, an interpretive system for hepatitis serology tests. CDS Hooks defines FHIR as the only data source. ArdenSuite, in contrast, offers the option of various data sources with connectors and extensions.
MICROFLUIDIC CELL SORTER AIDED LIVE CELL SCREENING FOR IMPROVED FLUORESCENT PROTEIN

We demonstrate a simple and low cost microFACS platform with an integrated piezoelectric actuator for directed evolution of fluorescence protein (FP) and FP-based indicators with high throughput up to 500 cells/s. The system was first employed to screen a 10 6 member library of a novel yellow FP. Compared to the manual on-plate screening method, the average brightness of the top 10 variants identified by our system was 50% brighter. The system also achieved 6-fold enrichment in isolating cells expressing superior FP-based indicator G-GECO1.0 from flash-pericam, showing the capability of screening FP-based indicators for brighter fluorescence and better functions.
Comparative Analysis of Mitigating THD with Conventional & Proposed UPQC with non-linear Load Conditions

Power Quality (PQ) mainly handles with issues like maintaining a fixed voltage at the Point of Common Coupling (PCC) for various distribution voltage levels heedless of voltage fluctuations, maintaining nearly unity power factor power drawn from the supply. Flexible AC Transmission Systems (FACTS) and Custom Power products like STATCOM, DVR and UPQC handles with the issues related to power quality using similar control strategies and concepts. Unlike DVR and STATCOM, unified power quality conditioner (UPQC) employs the integration of both series-active and shunt-active power filters to mitigate any type of voltage and current fluctuations and power factor correction in a power distribution network. The unified power quality conditioner (UPQC) is being used as a universal active power conditioning device to mitigate both current and voltage harmonics at a distribution side of power system network. This paper emphasizes the importance of UPQC application for better power quality, by comparing the mitigated voltage and current THD values with a conventionally modelled UPQC and a proposed PI-Resonant controller in mitigating THD’S of voltage and current at the load side in the system
COMPARATIVE KARYOTYPE AND RAPD ANALYSIS OF FOUR VARIETIES OF ALLIUM CEPA L . AND A SPECIES OF ALLIUM FISTULOSUM L .

Four varieties of Allium cepa L. viz., BARI Piaz-1, BARI Piaz-3, BARI Piaz-4 and BARI Piaz-5 and a species of Allium, namely A. fistulosum L. were cytogenetically studied. In addition, DNA fingerprinting by using RAPD was also carried out to make phylogenetic dendrogram. The chromatins were homogeneously distributed in the interphase nuclei and prophase chromosomes of five specimens and they were found to possess 2n = 16 chromosomes. The highest number of acrocentric chromosomes was found in Allium fistulosum while no acrocentric chromosome found in BARI Piaz-4. This result indicated advanced karyotype in A. fistulosum. Each specimen showed characteristic RAPD fingerprinting. The unique RAPD fragments could be used as marker for these respective specimens. The cytogenetical and RAPD data support that A. fistulosum is totally different from rest four specimens. Introduction Allium species are important herbaceous plants used as spices as well as vegetables in the world. In early classifications of angiosperms, Allium species were placed in the Liliaceae, later they were more often included in the Amaryllidaceae on the basis of their fluorescence structure (Paknia and Karimzadeh 2010). The genus Allium comprises of some 750 species (Friesen et al. 2006), including both wild and cultivated plants (Negi 2006). Allium includes many economically important species which are extensively used as a condiment in the preparation of many kinds of foods and it is an integral part of the world diet. In case of onion (Allium sp.), the main usable part is the fleshy scaly-leaf bases, usually known as bulbs. Moreover, the whole immature plant, the leaves and also the peduncle are used as vegetables. Onion contains 89% water, 4% sugar, 1% protein, 2% fibre and 0.1% fat. It contains vitamin B and a trace of vitamin C and also trace of iron, calcium and volatile oil known as allylpropyl-disulphide (Yawalkar 1985). It has anti-rheumatic, diuretic and antibacterial properties and reduces the insulin requirement of diabetic patients and decreases serum cholesterol. It is regarded as a stimulant and aphrodisiac (Ghani 2003). In Bangladesh, onion ranks first and second among all spices and condiment crops grown in respect of production and area, respectively (BBS 2004). Bangladesh Agriculture Research Institute (BARI) has successfully released five varieties of onion, namely Allium cepa (BARI Piaz-1, BARI Piaz-2, BARI Piaz-3, BARI Piaz-4 and BARI Piaz-5) and a species of Allium fistulosum. They were characterized on the basis of phenotypic and agronomic features without any basic knowledge of their genome. It is well-known that, for authentic identification of a specimen, genomic information is essential. The karyotype analysis is a dependable method in the identification and design of the chromosomes of animals and plants (Okumus and Hasan 2000). A complete idea about the karyotype of a germplasm is an important prerequisite for effective plant Author for correspondence: <kazinahida@yahoo.com>.
Helicobacter Pylori Infection in Patients With Neurological Symptoms of Vitamin B 12 Deficiency

Helicobacter Pylori Infection in Patients With Neurological Symptoms of Vitamin B12 Deficiency Tuba Aydemir ÖZCAN, Kadir AKSÖZ, Nazan AKSOY, Tevfik NOYAN Ordu University, School of Medicine, Neurology, Ordu, Türkiye Ordu University, School of Medicine, Gastroenterology, Ordu, Türkiye Ordu University, Training and Research Hospital, Pathology, Ordu, Türkiye Ordu University, School of Medicine, Biochemistry, Ordu, Türkiye
Storytime-End to end neural networks for audiobooks

Audio books serve as a gold standard for text to speech synthesis. Since they last for hours, small idiosyncrasies in their prosody quickly become overwhelming to a listener. Storytime originated from the inspiration that we can use neural networks to reach a new level of fluidity for spoken text. More specifically, we explored an implementation of Tacotron, a recent academic publication from Google. It relies on an encoder, decoder, and attention to simulate near-human spectrogram. As of the beginning of this project, there were no public attempts at duplicating their results. We made great strides in exploring their paper implementation specifics and report these modeling decisions in detail, in the hopes that these can push the state of the art forward for getting similar models used in practice. At the end of the day, we trained a successful proof of concept of our model.
Learning the mapping from surface to underlying representations in an artificial language

When infants acquire their native language they not only extract languagespecific segmental categories and the words of their language, they also learn the underlying form of these words. This is difficult because words can have multiple phonetic realizations, according to the phonological context. In a series of artificial language-learning experiments with a phrase-picture matching task, we consider the respective contributions of word meaning and distributional information for the acquisition of underlying representations in the presence of an allophonic rule. We show that on the basis of semantic information, French adults can learn to map voiced and voiceless stops or fricatives onto the same underlying phonemes, whereas in their native language voicing is phonemic in all obstruents. They do not extend this knowledge to novel stops or fricatives, though. In the presence of distributional cues only, learning is much reduced and limited to the words subjects are trained on. We also test if phonological naturalness plays a role in this type of learning, and find that if semantic information is present, French adults can learn to map different segments onto a single underlying phoneme even if the mappings are highly unnatural. We discuss our findings in light of current statistical learning approaches to language acquisition.
Development and Validation of a Stability-Indicating HPLC Method for the Simultaneous Determination of Salbutamol Sulphate and Theophylline in Pharmaceutical Dosage Forms

The study describes development and subsequent validation of a stability indicating reverse-phase high- performance liquid chromatography method for the simultaneous estimation of salbutamol sulphate and theophylline in tablet dosage forms. A reversed-phase phenomenax C-18 column (250 mm × 8 mm i.d., particle size 10 μm) column with mobile phase consisting of acetonitrile and phosphate buffer 65:35 (v/v) (pH 4.2 ± 0.02, adjusted with triethylamine) was used. The flow rate was 1.2 mL min -1 and effluents were monitored at 235 nm. The retention times (t R ) of salbutamol sulphate and theophylline were found to be 5.33 min and 13.36 min, respectively. The method was validated in terms of linearity, range, specificity, accuracy, precision, limit of detection (LOD) and limit of quantitation (LOQ). The linearity for both the drugs was found in the range of 2-64 μg mL -1 . The % recoveries of salbutamol sulphate and theophylline were found to be 99.41 and 101.11, respectively. The utility of the procedure is verified by its application to marketed formulations that were subjected to accelerated degradation studies. The method distinctly separated the drug and degradation products even in actual samples. The products formed in marketed tablet dosage forms are similar to those formed during stress studies.
Towards Privacy-Aware Location-Based Recommender Systems

With the diffusion of new generations of GPS-enabled smartphones, location-based recommender systems are appearing on market, allowing users to get personalized suggestions on-the-go about new places to visit based on user tastes. Although these systems are getting very popular and their functionalities look very attractive to users, a number of location-privacy issues are arising. In this paper we give an overview of the working principles of current location-based recommender systems, analysing them from the user privacy perspective. We then call for a new approach to location-based recommendation based on homomorphic encryption in order to enhance users’ privacy.
ASSESSMENT OF NATURAL RADIOACTIVITY IN WATER AND SEDIMENT FROM AMANG (TIN TAILING) PROCESSING PONDS

Gamma spectroscopy was performed to determine the concentrations of uranium-238 and thorium-232 concentrations in the environment as a consequence of amang processing. In this study 33 water samples and 26 sediment samples were collected from 7 amang processing areas. The concentrations of uranium-238 and thorium-232 were determined by direct counting using a hyper pure germanium (HPGe) detector inter phased with a multi channel analyzer (MCA) . Results showed that the maximum mass and activity concentrations of uranium in water samples were 6.64 ppm and 78.53 Bql -1 respectively, while in sediment samples were 69.75 mgkg -1 and 860.57 Bqkg -1 respectively. The maximum mass and activity concentrations of thorium in water samples were 1.71 ppm and 6.90 Bql -1 , while in sediment samples were 157.73 mgkg -1 and 637.61 Bqkg -1 respectively. Concentrations of uranium-238 and thorium-232 in sediment samples were higher than concentrations of uranium-238 and thorium-232 in water samples, and this may be attributed to insolubility of these radionuclides in water. The concentrations of both radionuclides were higher in sediments collected from ponds involved in the close water recycle system compared to those ponds involved in the open water system. Results also showed that the concentrations of these radionuclides were higher than background indicating that amang processing activity has enhanced the natural radionuclides contents in water and sediment.
Gender Determination by Diagonal Distances Of Teeth

Teeth form an excellent material for anthropological, genetic, odontologic and forensic investigations. Gender determination of skeletal remains is part of the archaeological, anthropology and many medico-legal examinations. The methods vary and depend on the available bones and their condition. The only method that can give a totally accurate result is the DNA technique, but in many cases for several reasons it cannot be used. The purpose of this study was to investigate the accuracy with which gender can be differentiated by odontometric analyses in a North Indian population. The material consisted of 445 dental casts (233M:212F) in the age group of 17-57 years. Measurements were made on the mesio buccal, distolingual and distobuccal mesiolingual diameters by digital vernier caliper. Mandibular canine (p<0.001) had significant mean differences in all measurements. It also showed high significant dimorphic values for some of the other variables investigated for future study.
Effectiveness of a counseling intervention following a traumatic childbirth : A randomized controlled trial

Adverse childbirth experiences can evoke fear and overwhelming anxiety for some women and precipitate posttraumatic stress disorder. The objective of this study was to assess a midwife‐led brief counseling intervention for postpartum women at risk of developing psychological trauma symptoms. Method: Of 348 women screened for trauma symptoms, 103 met inclusion criteria and were randomized into an intervention (n = 50) or a control (n = 53) group. The intervention group received face‐to‐face counseling within 72 hours of birth and again via telephone at 4 to 6 weeks postpartum. Main outcome measures were posttraumatic stress symptoms, depression, self‐blame, and confidence about a future pregnancy. Results: At 3‐month follow‐up, intervention group women reported decreased trauma symptoms, low relative risk of depression, low relative risk of stress, and low feelings of self‐blame. Confidence about a future pregnancy was higher for these women than for control group women. Three intervention group women compared with 9 control group women met the diagnostic criteria for posttraumatic stress disorder at 3 months postpartum, but this result was not statistically significant. Discussion: A high prevalence of postpartum depression and trauma symptoms occurred after childbirth. Although most women improved over time, the intervention markedly affected participants' trajectory toward recovery compared with women who did not receive counseling. Conclusions: A brief, midwife‐led counseling intervention for women who report a distressing birth experience was effective in reducing symptoms of trauma, depression, stress, and feelings of self‐blame. The intervention is within the scope of midwifery practice, caused no harm to participants, was perceived as helpful, and enhanced women's confidence about a future pregnancy. Adverse childbirth experiences related to unexpected medical intervention, severe pain, or threat of death may evoke fear and overwhelming anxiety for some women and precipitate posttraumatic stress disorder (1–5). Trauma symptoms may include flashbacks, nightmares, numbness, irritability, sleep disturbances, anger, being easily startled, hypervigilance (especially about the baby), avoidance of all reminders of the traumatic event, panic attacks, physiological responses such as sweating, and palpitations when exposed to things that remind the woman of the traumatic birth (6). Significant co‐morbidity of depression and posttraumatic stress can occur, and both conditions share some similar symptoms (7,8). Furthermore, the consequences of postpartum emotional distress can be far reaching. Children of women who suffer mood disorders can have long‐term disturbances to their emotional, behavioral, and cognitive development (9–
Hydrogen-Bonding Molecular Assemblies of Alkylamide-Substituted Isophthalic Acid Derivative

[Abstract] Alkylamide-substituted isophthalic acid derivatives can form interesting hydrogen-bonding molecular assemblies. Gelation behavior and liquid crystal (LC) formation are evaluated in the structural parameter of alkyamide chain length (n) at –CONHCnH2n+1. All compounds (n = 6, 10, 14, and 18) show the gelation behavior in the mixed solvent system of C2H5OH-H2O, where H2O is necessary for the gelation behavior, suggesting in the formation of tubular assembly structure with the hydrophilic inside pore. In addition, different LC phases of hexagonal columnar (Colh) and lamellar phases (DL1) are observed by changing in the structural parameter of n and introducing guest H2O molecules.