Miracle-dz/UniFAR-FTUs huggingface dataset:
Strength and Conditioning Practices in Adolescent Rugby Players: Relationship with Changes in Physical Qualities.

Adolescent rugby players benefit from the implementation of resistance training. However resistance training practices and how they influence short-term physical change is unknown. Therefore the purpose of this study was to quantify resistance training practices, evaluate physical development, and relate these changes to resistance training variables across 12-weeks in adolescent rugby union players. Thirty-five male adolescent rugby union players participated in the study with subjects completing an anthropometric and physical testing battery pre- and post- a 12-week in-season mesocycle. Subjects recorded resistance training frequency, exercises, repetitions, load, minutes, and rating of perceived exertion for each session using weekly training diaries during the 12-week period. Paired sample t-tests and Cohen's d effect sizes were used to assess change, while Pearson correlation coefficients assessed relationships between variables. Resistance training practices were variable, while significant (p ≤0.05) improvements in body mass, countermovement jump (CMJ) height, front squat, bench press, and chin up strength were observed. Resistance training volume load had moderate to strong relationships with changes in CMJ (r =0.71), chin up (r =0.73) and bench press (r =0.45). Frequency of upper and lower body compound exercises had significant moderate to large relationships with changes in CMJ (r =0.68), chin up (r =0.65), and bench press (r =0.41). Across a 12-week in-season period, adolescent rugby union players have varying resistance training practices, while anthropometric and physical characteristics appear to improve. Given the observed relationships, increased volume loads through the implementation of free-weight compound exercises could be an effective method for improving physical qualities in young rugby players.
Electron irradiation slows down wound repair in rat skin: a morphological investigation

Summary To date, there have been few morphological investigations of the effect of electron radiation on the healing of skin wounds in rats. The present morphological study examines the wound repair process in electron‐irradiated rat skin by electron microscopy. Standardized, full‐thickness, incisional wounds were made in the lower dorsal skin of animals which had been locally irradiated with 9·6 Gy electron radiation 7 days previously. The irradiation dose was maximal at 3 mm depth. Twenty‐four rats were used in the investigation: 12 were irradiated and 12 sham‐irradiated. Three rats from each experimental group were killed at 1, 3, 7 and 14‐day time intervals after wounding. The morphological effect of electron irradiation on the repair of each wound was investigated by light microscopy (LM) and scanning electron microscopy (SEM). New granulation tissue visualized by SEM was quantified using computerized image analysis. The results suggest that a single, partial‐body, controlled depth dose of electron irradiation delays wound repair. LM showed that there is a depression of the inflammatory cell and tissue exudate response, slowing of epithelial migration, and a decrease in fibroblast representation, together with a delay in the formation of collagen bundles. Granulation tissue formation was impaired up to 7 days post‐wounding, but was restored to around control values by day 14, indicating that healing was delayed. However, as the healing of normal tissue was not prevented, this study supports a preoperative role for the use of low‐dose electron irradiation therapy for the treatment of electron‐sensitive superficial pathologies in surgical practice.
Integration of a Decentralised Pattern Matching: Venue for a New Paradigm Intermarriage

We provide a new technique for pattern matching that is based on components for each match. The set of match statements and their order is open for conﬁguration at the right time and takes place in a feature-oriented fashion. This gives rise to a solution to the Expression Problem in presence of defaults. It takes a lightweight discipline to develop components for our technique. Their use for conﬁguration of the pattern match, however, is virtually automatic.
Preclinical evaluation of a bispecific low‐molecular heterodimer targeting both PSMA and GRPR for improved PET imaging and therapy of prostate cancer

It has recently been reported that metastases of prostate cancer usually show highly heterogeneous or partly lost prostate‐specific membrane antigen (PSMA) expression. In order to image and treat both PSMA positive and negative tissues PSMA targeting probes need to be extended by a further specificity. Since prostate cancer cells usually express both PSMA and gastrin‐releasing peptide receptor (GRPR) a bispecific low‐molecular heterodimeric molecule, addressing both targets at the same time, may significantly improve prostate cancer imaging and therapy.
A System Framework for Concept- and Credibility-Based Multimedia Retrieval

We present a multimedia retrieval system framework that incorporates components for processing multimedia content in different modes and languages. The framework provides concept-based information retrieval facilities that applies credibility information for result re-ranking. The architecture combines both a direct user interface and a batched evaluation interface for reproducible research in multimedia IR. The demo presents a preliminary version of the system framework and shows a use case based on the ImageCLEF 2011 Wikipedia test collection.
ABO-compatible liver allograft antibody-mediated rejection: an update

Purpose of reviewLiver allograft antibody-mediated rejection (AMR) studies have lagged behind parallel efforts in kidney and heart because of a comparative inherent hepatic resistance to AMR. Three developments, however, have increased interest: first, solid phase antibody testing enabled more precise antibody characterization; second, increased expectations for long-term, morbidity-free survival; and third, immunosuppression minimization trials. Recent findingsTwo overlapping liver allograft AMR phenotypic expressions are beginning to emerge: acute and chronic AMR. Acute AMR usually occurs within the several weeks after transplantation and characterized clinically by donor-specific antibodies (DSA) persistence, allograft dysfunction, thrombocytopenia, and hypocomplementemia. Acute AMR appears histopathologically similar to acute AMR in other organs: diffuse microvascular endothelial cell hypertrophy, C4d deposits, neutrophilic, eosinophilic, and macrophag-mediated microvasculitis/capillaritis, along with liver-specific ductular reaction, centrilobular hepatocyte swelling, and hepatocanalicular cholestasis often combined with T-cell-mediated rejection (TCMR). Chronic AMR is less well defined, but strongly linked to serum class II DSA and associated with late-onset acute TCMR, fibrosis, chronic rejection, and decreased survival. Unlike acute AMR, chronic AMR is a slowly evolving insult with a number of potential manifestations, but most commonly appears as low-grade lymphoplasmacytic portal and perivenular inflammation accompanied by unusual fibrosis patterns and variable microvascular C4d deposition; capillaritis can be more difficult to identify than in acute AMR. SummaryMore precise DSA characterization, increasing expectations for long-term survival, and immunosuppression weaning precipitated a re-emergence of liver allograft AMR interest. Pathophysiological similarities exist between heart, kidney, and liver allografts, but liver-specific considerations may prove critical to our ultimate understanding of all solid organ AMR.
Health information Websites: characteristics of US users by race and ethnicity

We conducted a national public opinion survey of adults aged 18 years or older in the continental US to determine their use of health Websites. Of the 928 individuals contacted, 868 (94%) reported their race/ethnicity. More non-Hispanic Whites reported using the Internet (34%) than African Americans (31%) and Hispanics (20%). We used logistic regression to estimate adjusted odds ratios describing the relationship between Website usage and covariates across the racial/ethnic subgroups. Whereas better perceived health was associated with greater Website use among Hispanics and Whites, stronger health literacy was associated with greater use among Hispanics. No African American or Hispanic respondent aged 65 years or older reported going online. The relationship between education and use was more than twice as strong for African Americans and Hispanics than other groups. That some minority groups are less likely to use the World Wide Web for health information may further compound existing disparities. One place where this problem may be addressed is in the nation's schools.
The Significant Cardiomyogenic Potential of Human Umbilical Cord Blood‐Derived Mesenchymal Stem Cells In Vitro

We tested the cardiomyogenic potential of the human umbilical cord blood‐derived mesenchymal stem cells (UCBMSCs). Both the number and function of stem cells may be depressed in senile patients with severe coronary risk factors. Therefore, stem cells obtained from such patients may not function well. For this reason, UCBMSCs are potentially a new cell source for stem cell‐based therapy, since such cells can be obtained from younger populations and are being routinely utilized for clinical patients. The human UCBMSCs (5 × 103 per cm2) were cocultured with fetal murine cardiomyocytes ([CM] 1 × 105 per cm2). On day 5 of cocultivation, approximately half of the green fluorescent protein (GFP)‐labeled UCBMSCs contracted rhythmically and synchronously, suggesting the presence of electrical communication between the UCBMSCs. The fractional shortening of the contracted UCBMSCs was 6.5% ± 0.7% (n = 20). The UCBMSC‐derived cardiomyocytes stained positive for cardiac troponin‐I (clear striation +) and connexin 43 (diffuse dot‐like staining at the margin of the cell) by the immunocytochemical method. Cardiac troponin‐I positive cardiomyocytes accounted for 45% ± 3% of GFP‐labeled UCBMSCs. The cardiomyocyte‐specific long action potential duration (186 ± 12 milliseconds) was recorded with a glass microelectrode from the GFP‐labeled UCBMSCs. CM were observed in UCBMSCs, which were cocultivated in the same dish with mouse cardiomyocytes separated by a collagen membrane. Cell fusion, therefore, was not a major cause of CM in the UCBMSCs. Approximately half of the human UCBMSCs were successfully transdifferentiated into cardiomyocytes in vitro. UCBMSCs can be a promising cellular source for cardiac stem cell‐based therapy.
Solving a multi-objective mixed-model assembly line balancing and sequencing problem

This research addresses the mixed-model assembly line (MMAL) by considering various constraints. In MMALs, several types of products which their similarity is so high are made on an assembly line. As a consequence, it is possible to assemble and make several types of products simultaneously without spending any additional time. The proposed multi-objective model considers the balancing and sequencing problems, simultaneously. Based on the assembly problem, the various tasks of models are assigned to the workstations, while in the sequencing problem, a sequence of models for production is determined. The two meta-heuristic algorithms, namely MOPSO and NSGA-II are used to solve the developed model and different comparison metrics are applied to compare these two proposed meta-heuristics. Several test problems based on empirical data is used to illustrate the performance of our proposed model. The results show that NSGA-II outperforms the MOPSO algorithm in most metrics used in this paper. Moreover, the results indicate that our proposed model is more effective and efficient to assignment of tasks and sequencing models than manual strategy. Finally, conclusion remarks and future research are provided.
Genetic Background Affects Stability of mecA in Staphylococcus aureus

ABSTRACT The staphylococcal methicillin resistance determinant, mecA, resides on a mobile genetic element, staphylococcus chromosomal cassette mec (SCCmec). The distribution of SCCmec in nature is limited to relatively few clonal complexes of related methicillin-resistant Staphylococcus aureus (MRSA). We have previously reported that some genetic backgrounds are restrictive of mecA and penicillin-binding protein 2a expression, which could account for the restricted clonal distribution of SCCmec in nature. In this study, we investigate the potential role of the host chromosome in the transformability and expression of mecA in 103 naturally occurring methicillin-susceptible S. aureus clinical isolates. The isolates, which had been genotyped previously by multilocus sequence typing, were classified into one of two mutually exclusive categories based on whether the isolates belonged to “major” MRSA lineages or to “other” lineages that are never or occasionally MRSA. We introduced mecA expressed on the low-copy-number plasmid pYK20 into each MSSA strain and assayed the phenotype of resistance to nafcillin by population analysis to assess the relationship between the stability of mecA expression and genetic background. Strains from the major MRSA lineages were more transformable with pYK20 and better able to maintain the plasmid and express resistance in comparison to strains from other lineages. These data support the hypothesis that the presence of mecA within relatively few clonal complexes is partly due to genetic factors that are permissive of mecA and its gene product.
Exfoliation of Threading Dislocation‐Free, Single‐Crystalline, Ultrathin Gallium Nitride Nanomembranes

Despite the recent progress in gallium nitride (GaN) growth technology, the excessively high threading dislocation (TD) density within the GaN crystal, caused by the reliance on heterogeneous substrates, impedes the development of high‐efficiency, low‐cost, GaN‐based heterostructure devices. For the first time, the chemical exfoliation of completely TD‐free, single‐crystalline, ultrathin (tens of nanometers) GaN nanomembranes is demonstrated using UV‐assisted electroless chemical etching. These nanomembranes can act as seeding layers for subsequent overgrowth of high‐quality GaN. A model is proposed, based on scanning and transmission electron microscopy as well as optical measurements to explain the physical processes behind the formation of the GaN nanomembranes. These novel nanomembranes, once transferred to other substrates, present a unique and technologically attractive path towards integrating high‐efficiency GaN optical components along with silicon electronics. Interestingly, due to their nanoscale thickness and macroscopic sizes, these nanomembranes may enable the production of flexible GaN‐based optoelectronics.
Gabor/PCA/SVM-Based Face Detection for Driver's Monitoring

Driver fatigue cause each year a large number of road traffic accidents, this problem sparks the interest of research to move towards development of systems for prevention of this phenomenon. This article implements a face detection process as a preliminary step to monitor the state of drowsiness on vehicle's drivers. We propose an algorithm for pre-detection based on image processing and machine learning methods. A Gabor filter bank is used for facial features extraction. The dimensionality of the resulting feature space is further reduced by PCA technique and then follows a classification of Face/No Face classes using Support Vector Machine (SVM), for face detection. The simulation results on both databases namely PIE and ORL datasets show the efficiency of this approach. 
Clinical outcome after insemination with donor sperm in patients with poor results in ICSI cycles

The introduction of intracytoplasmic sperm injection (ICSI) provided an effective treatment for infertile couples whose infertility was attributed to male factors. However, some of them face poor results after ICSI and subsequently use artificial insemination with donor sperm (AID). Only a few studies have reported on the clinical outcome of AID cycles after previous failed ICSI cycles, with contrasting results. The results reported here involve a cohort of 47 couples undertaking 175 AID cycles after 120 failed ICSI cycles for various reasons. Couples were allocated to two groups according to the availability of top quality embryos (TQE) in ICSI cycles. In our series, AID was successful for couples with and without TQE previously transferred in ICSI cycles, the live birth rate (LBR) per cycle being 20.0% and 13.3%, respectively. However, couples with TQE tended to succeed more rapidly than couples with poor quality embryos, with a higher cumulative LBR (68.0% versus 54.5%, respectively). These findings demonstrate that even couples with a history of unsuccessful ICSI cycles because of poor embryo quality are able to achieve high LBR after AID cycles. However, such couples have a lower cumulative LBR and are required to be more patient to achieve parenthood.
Apoptosis, bcl-2 Expression and p53 Accumulation in Myelodysplastic Syndrome, Myelodysplastic-Syndrome-Derived Acute Myelogenous Leukemia and de novo Acute Myelogenous Leukemia

Apoptosis and its dysregulation have been implicated in dysplastic and ineffective hematopoiesis and the neoplastic transformation of bone marrow in myelodysplastic syndrome (MDS). To explore the role of apoptosis in hematological disorders, we examined the frequency of apoptotic cells by the in situ end labeling method in bone marrow specimens from 37 patients with MDS [refractory anemia (RA) 10 cases, RA with excess of blasts (RAEB) 27 cases including 12 cases with leukemic transformation], 12 patients with MDS-derived acute myelogenous leukemia (AML) and 13 patients with de novo AML. In addition, we investigated the relationship of apoptosis to the immunohistochemical expression of bcl-2 and p53 in these cases, and the association of apoptosis, bcl-2, and p53 with the leukemic evolution of MDS by examining sequential bone marrow samples of the same patient from the time of initial diagnosis to the time of overt leukemia. The percentage frequency of apoptotic cells was significantly greater in MDS (RA: 9.46 ± 2.99%, m ± SD; RAEB: 5.60 ± 3.09) as compared with those in MDS-derived AML (0.62 ± 0.37), de novo AML (0.28 ± 0.11) and controls (1.00 ± 0.59). On the other hand, the cases of RAEB with leukemic transformation exhibited a lower frequency of apoptotic cells and a higher frequency of bcl-2- and p53-positive cells than those without transformation. When the RAEB cases transformed to AML, the frequency of apoptotic cells was significantly reduced (2.96 ± 1.54 → 0.62 ± 0.37), while the frequencies of bcl-2-positive cells and p53-positive cells were greater (10.88 ± 3.66 → 30.54 ± 7.14, and 20.21 ± 6.21 → 32.34 ± 14.71, respectively). In contrast to MDS-derived AML, over a half of de novo AML cases showed few p53-positive cells. These findings corroborate the earlier notion that apoptosis may play a substantial role in dysplastic and ineffective hematopoiesis in MDS. It is also suggested that the suppression of apoptosis associated with enhanced bcl-2 expression and p53 accumulation increases the probability of developing leukemia in MDS, and that oncogenetic development might be different between MDS-derived AML and de novo AML.
Outcome in consecutive emergency department attenders following a road traffic accident

Background Little is known about the consequences of road traffic accidents. Aims To determine psychological and social outcome at 3 months and I year following a road traffic accident. Method A cohort study of a 1-year sample of consecutive attenders (n=1148) aged 17–69 years at the accident and emergency department of a teaching district general hospital (excluding major head injury). Data were extracted from medical notes and from self-report at baseline, 3 months and 1 year. Results Most (61%) injuries were physically minor. At 1 year 45% reported major physical problems and 32% reported psychiatric consequences. Non-injury variables were the principal predictors of outcome. Conclusions Outcome across a range of variables is considerably worse than would be expected from the nature of the physical injuries. There is a need for changes in clinical care and socio-legal policy to prevent, identify and treat distressing and disabling chronic problems.
Comparison of Anthropometric Characteristics in Predicting the Incidence of Type 2 Diabetes in the EPIC-Potsdam Study A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

Obesity is a well-established risk factor for type 2 diabetes (1–3). However, while several studies (4–10) suggest that anthropometric measurements that describe central fat distribution are superior in predicting type 2 diabetes compared with measurements of general adiposity, this issue remains controversial (11–14). The aim of this study was to compare different anthropometric measurements and derived estimates of body composition, in particular BMI, waist-to-height ratio, waist-to-hip ratio (WHR), metric index, and percentage body fat, in their ability to predict risk of type 2 diabetes in a large prospective cohort study of men and women. The European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study includes 27,548 subjects, 16,644 women aged mainly 35–65 years and 10,904 men aged mainly 40–65 years, from the general population of Potsdam, Germany, recruited between 1994 and 1998 (15). The baseline examination included anthropometric measurements (16,17) as well as a personal interview and a questionnaire on prevalent diseases and sociodemographic and lifestyle characteristics. Follow-up questionnaires have been administered every 2–3 years. Response rates for follow-up rounds 1, 2, 3, and 4 were 96, 95, 91, and 90% (31 August 2005), respectively. All potential incident cases of diabetes were verified by the diagnosing physician using …
TRPA1 activation in a human sensory neuronal model: relevance to cough hypersensitivity?

The cough reflex becomes hyperresponsive in acute and chronic respiratory diseases, but understanding the underlying mechanism is hampered by difficulty accessing human tissue containing both nerve endings and neuronal cell bodies. We refined an adult stem cell sensory neuronal model to overcome the limited availability of human neurones and applied the model to study transient receptor potential ankyrin 1 (TRPA1) channel expression and activation. Human dental pulp stem cells (hDPSCs) were differentiated towards a neuronal phenotype, termed peripheral neuronal equivalents (PNEs). Using molecular and immunohistochemical techniques, together with Ca2+ microfluorimetry and whole cell patch clamping, we investigated roles for nerve growth factor (NGF) and the viral mimic poly I:C in TRPA1 activation. PNEs exhibited morphological, molecular and functional characteristics of sensory neurons and expressed functional TRPA1 channels. PNE treatment with NGF for 20 min generated significantly larger inward and outward currents compared to untreated PNEs in response to the TRPA1 agonist cinnamaldehyde (p<0.05). PNE treatment with poly I:C caused similar transient heightened responses to TRPA1 activation compared to untreated cells. Using the PNE neuronal model we observed both NGF and poly I:C mediated sensory neuronal hyperresponsiveness, representing potential neuro-inflammatory mechanisms associated with heightened nociceptive responses recognised in cough hypersensitivity syndrome. Development of a novel human adult stem cell neuronal model to investigate neural hyperresponsiveness in cough http://ow.ly/Ilvb30eokUC