Miracle-dz/UniFAR-FTUs huggingface dataset:
Using the Pharmacophoric features of Azithromycin to design potential SARS-CoV-2 inhibitor

The outbreak of novel coronavirus (SARS-CoV-2) found in Wuhan China is rapidly spreading to all nations of the world. Currently, there are no approved drugs for the treatment of the novel coronaviral disease. Meanwhile, repositioning of some antibiotics, antiviral and antimalaria drugs have been employed. In this study, we used azithromycin as a model drug to virtual screen the ZINC database and the molecules obtained were docked against SARS-CoV-2 protein with PDB code: 5r7y. The best five ligands with high affinity for the target protein was compared with the reference molecule (Azithromycin). The docking score for the predicted ligands with high affinity for the target protein include ZINC10635972 (-6.3 kcal/mol), ZINC02651653 (-6.2 kcal/mol), ZINC09728215 (-6.2 kcal/mol), ZINC15003138 (-6.1 kcal/mol), ZINC89836288 (-6.1 kcal/mol) and azithromycin (+28.2 kcal/mol). The lead molecule (ZINC10635972) was observed to interacted with LUE 141, ASN 142, SER 144, SER 46, GLY 189, GLU 166, MET 165, HIS163, MET 49, HIS 164, PHE 140, GLY 143,THR 25, CYS 145, HIS 41, CYS 44 and THR 45. Meanwhile, hydrogen bond was predominant in the ZINC10635972-5r7y interaction. The lead molecule demonstrated good pharmacokinetics properties, drug-like characteristic and moderate chemical reactivity index. Besides, ZINC10635972 was noticed to fit the class 5 toxicity index. Hence, ZINC10635972 is a promising compound that should be further examined as drug candidates before clinical evaluation.
Variety x Location Interaction on Oil, Fatty acids, Tocopherols and Phytosterols in Korean Rapeseed (Brassica napus L.)

Rapeseeds have many health benefits because its oil is rich in polyunsaturated and monounsaturated fatty acids, tocopherols and phytosterols. The objective of this research was to examine a possible genetic variation of oil, fatty acids, tocopherols and phytosterols in eight rapeseed varieties and the effect of locations on expression of those chemical compounds. In this study, effects of variety x location interaction for palmitic, stearic, oleic, linoleic, linolenic, eicogenic and erucic contents were found to be significant while that of oil content was not. For oil content, variation between the two locations was much higher than all other factors. Variation among varieties was the major source of variation in most fatty acids. Variation between two locations was much less for tocopherols and phytosterols than that for oil and fatty acids. Instead, variation in residual effect was much higher in tocopherols and phytosterols demanding more number of replication to achieve same level of statistical precision as oil and fatty acids. Correlation analyses confirmed that some of the chemical compounds can be a target for indirect selection.
The Distribution of British Liverworts: A Statistical Analysis

It is important to try to generalize data on plant distribution for two reasons. Firstly, ecological or experimental work on a particular species then need not be considered in isolation, but can be related to other species of similar (or contrasting) distribution types. Secondly, it becomes possible to see which features appear repeatedly in the distribution patterns of different species, and hence are likely to be of general importance, and which are fortuitous or peculiar to particular species. We are fortunate in Britain in having a long tradition of plant recording based on the Watsonian vice-counties; the results of this tradition are exemplified by the Census Catalogues of British mosses and hepatics published by the British Bryological Society (Warburg 1963; Paton 1965). These show at a glance the main features of the British distribution of any species, and it is easy to extract a list of the species recorded from any vice-county. It is, however, very much more difficult to discern general patterns and relationships.
Nanostructured and Heterostructured 2D Materials for Thermoelectrics

The rapid development in the synthesis and device fabrication of 2D materials provides new opportunities for their wide applications in a variety of fields including thermoelectric energy conversion, thermal management, and thermal logics. As one important research direction, the possibly poor thermoelectric performance of the pristine 2D materials can be dramatically improved with patterned nanostructures, stacking of different 2Ds to form layered heterostructures, and electrostatic gating allowing fine-tuning of the quasi Fermi-level. This article reviews the recent advancement in this direction, with emphasis on both fundamental understanding and practical problems.
Fungal colonization and breakdown of sedge (Cyperus malaccensis Lam.) in an Indian mangrove

Abstract We studied patterns of fungal colonization, mass loss and biochemical changes during decomposition of the dominant mangrove sedge Cyperus malaccensis in a mangal located in southwestern India. Litter bags containing dried bracts, basal stem and top stem were introduced into a sedge sward in a mid-tidal zone for periods of up to 8 weeks (April–June 2005). After retrieval of sedge substrates and incubation in the laboratory, 19 fungi (10 anamorphs, 8 ascomycetes and one zygomycete) were found. Terrestrial fungi dominated over the first 2–3 weeks. Later, in spite of falling water temperatures and salinity, they were replaced by typical mangrove/marine ascomycetes and anamorphs. Up to 79% of bract mass loss occurred in 4 weeks; respective losses for basal stems and top stems were 88% and 51% through 8 weeks. The estimated durations of 50% mass loss (t 50) were 4.5, 10.9 and 22.9 days for bract, basal stem and top stem, respectively. Accordingly, there were significant differences in daily decay coefficients (k) among substrates. Organic carbon and phenolics decreased steadily in all substrates. Phosphorus concentrations decreased, attained a minimum and increased again, reaching final concentrations similar to initial values. Nitrogen concentration increased through the end of the experiment. Cellulase, xylanase and pectinase in all sedge substrates generally peaked within 4 weeks. This is the first study on decomposition of the macrophyte C. malaccensis.
Influence of drip lateral placement depth and fertigation level on germination, yield and water-use efficiency of cucumber (Cucumis sativus)

A field experiment was conducted from February to June for three years (2009-2011) to evaluate the response of cucumber (Cucumis sativus L.) under 0 (surface) (D00), 5(D05), 10 (D10) and 15 (D15) cm depth of lateral placement and four levels of fertilizer application with NPK in the ratio of 50:30:30, 100:60:60, 120:90:90 and 150:120:120 kg/ha (F1, F2, F3 and F4). Uniformity of water application through subsurface drip irrigation (SDI) system was assessed every year. Soil moisture content in root zone, germination percentage, vine length and yield per plot were recorded and irrigation water use efficiency (IWUE) was estimated.It was observed that soil moisture content was higher and moisture profile was more uniform under SDI. Shallower depths of lateral, D00 and D05, resulted in higher seed germination percentage (92.8 and 90.2 %). Increased moisture and nutrient availability under D10 and D15 resulted in higher vine length (2.49 and 2.36m). During 2011, treatments D10 and D15 recorded highest mean yields of 31.7 and 32.9 t/ha, respectively. Fertigation level F3 recorded consistently higher mean yields for three consecutive cropping seasons yielding higher mean IWUE under D10 (0.49 to 0.81 t/ha/cm) and D15 (0.50 to 0.85 t/ha/cm). The results showed that SDI maintained uniform moisture in soil profile, minimized the evaporative loss and consequently increased IWUE. The SDI system with lateral placement depth of 10 cm and fertigation level F3 is recommended as an optimum practice for better yields and increased IWUE of cucumber cultivation.
Mannitol production in lactic acid bacteria

As calorie-consciousness and obesity became worldwide crisis day by day, demand for low calorie sweeteners is increasing. Mannitol is a natural sugar alcohol widely used in foods, pharmaceuticals and medical industry and considered to be half as sweet as sucrose. Reduced calorific value of mannitol (1.6 kilocalorie per gram) when compared to other sugars finds its application as a sweetener in low calorie foods. In a study conducted to identify LAB having significant mannitol production potential, Leuconostoc pseudomesenteroides IMAU: 11666 was found to be the best among the five unknown LAB isolates screened. Colorimetric assay was adopted for mannitol estimation and a yield of 0.65 g/l was observed from the above strain. The organism was identified by biochemical assays and confirmed by PCR and sequencing. Since production of mannitol by bacterial fermentation is more economical compared to industrial method of production, this specific strain can be utilised for economic production of mannitol.
Insect resistance of transgenic broccoli (‘Pusa Broccoli KTS-1’) expressing a synthetic cryIA(b) gene

Summary Broccoli has no suitable genes for insect resistance within the gene pool for transfer through conventional breeding. A protocol was optimized for transformation of hypocotyl explants of broccoli based on transient GUS expression. A synthetic cryIA(b) gene coding for an insecticidal crystal protein (ICP) of Bacillus thuringiensis (Bt) was transferred to the broccoli cultivar ‘Pusa Broccoli KTS-1’ by co-cultivating hypocotyls explants with Agrobacterium tumefaciens. Transformed plants resistant to kanamycin were regenerated. Molecular analysis demonstrated gene integration and expression. Immunoblot analysis revealed high-level expression of Bt toxin protein in the transgenic plants. In insect feeding bioassay, transgenics showed significant and effective resistance against the larvae of the diamondback moth (Plutella xylostella). Inheritance of the transgene was confirmed in Tl seedlings.
Manipulation of the epigenetic mark histone 3 lysine 9 tri-methylation (H3K9me3) in donor cells prior to nuclear transfer

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Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder

The role of astrocytes in neurodegenerative processes is increasingly appreciated. Here we investigated the contribution of astrocytes to neurodegeneration in multiple sulfatase deficiency (MSD), a severe lysosomal storage disorder caused by mutations in the sulfatase modifying factor 1 (SUMF1) gene. Using Cre/Lox mouse models, we found that astrocyte-specific deletion of Sumf1 in vivo induced severe lysosomal storage and autophagy dysfunction with consequential cytoplasmic accumulation of autophagic substrates. Lysosomal storage in astrocytes was sufficient to induce degeneration of cortical neurons in vivo. Furthermore, in an ex vivo coculture assay, we observed that Sumf1−/− astrocytes failed to support the survival and function of wild-type cortical neurons, suggesting a non-cell autonomous mechanism for neurodegeneration. Compared with the astrocyte-specific deletion of Sumf1, the concomitant removal of Sumf1 in both neurons and glia in vivo induced a widespread neuronal loss and robust neuroinflammation. Finally, behavioral analysis of mice with astrocyte-specific deletion of Sumf1 compared with mice with Sumf1 deletion in both astrocytes and neurons allowed us to link a subset of neurological manifestations of MSD to astrocyte dysfunction. This study indicates that astrocytes are integral components of the neuropathology in MSD and that modulation of astrocyte function may impact disease course.
Efficacy of the EPNs (Heterorhabditis bacteriophora Poinar, 1976) on sugar beet larvae (Bothynoderes punctiventris Germar 1824; Coleoptera: Curculionidae) in field conditions

The effectiveness of entomopathogenic nematode (EPN) Heterorhabditis bacteriophora Poinar, 1976 (Nematoda: Heterorhabditidae) infective juveniles (IJs) on sugar beet weevil (Bothynoderes punctiventris Germar, 1824 (Coleoptera: Curculionidae)) larvae was investigated during two-year (2014-2015). The field study was conducted to assess EPNs potential for use in practice. In field experiments, three doses of nematodes were used and an untreated control. In the conditions of moderate larval attack (average infestation of 0.28 larvae per plant), EPNs showed clear dose response being highly effective (92.86% control) when applied in the highest dose. Although the results indicated that H. bacteriophora could have a satisfactory mortality effect on sugar beet weevil larvae, further investigations are needed in order to better determine the optimal dose and application timing. If effective, EPNs could be used as one of the tools in a strategy which aims to reduce sugar beet weevil population levels in a wider area.
VerbNet based Citation Sentiment Class Assignment using Machine Learning

Citations are used to establish a link between articles. This intent has changed over the years, and citations are now being used as a criterion for evaluating the research work or the author and has become one of the most important criteria for granting rewards or incentives. As a result, many unethical activities related to the use of citations have emerged. That is why content-based citation sentiment analysis techniques are developed on the hypothesis that all citations are not equal. There are several pieces of research to find the sentiment of a citation, however, only a handful of techniques that have used citation sentences for this purpose. In this research, we have proposed a verb-oriented citation sentiment classification for researchers by semantically analyzing verbs within a citation text using VerbNet Ontology, natural language processing & four different machine learning algorithms. Our proposed methodology emphasizes the verb as a fundamental element of opinion. By developing and assessing the proposed methodology and according to benchmark results, the methodology can perform well while dealing with a variety of datasets. The technique has shown promising results using Support Vector Classifier.
A System Dynamics Model of Employees’ Performance

Employee performance is dynamic and can have great impact on the overall performance of any company and its sustainability. A number of factors that can be controlled by the company can affect the employees’ performance. The present paper starts with a thorough literature review for identifying these key driving in order to develop a system dynamics models that will be able to assess different improvement scenarios and initiatives. Based on causal loop diagrams, stock and flow diagrams are developed and solved using system dynamics theory. The model developed can be used for organizations to assess the impact of different improvement initiatives.
Preterm birth and low birth weight in neonates with postnatal respiratory failure at a tertiary hospital in Viet Nam

Use your smartphone to scan this QR code and download this article ABSTRACT Introduction: This study aimed to evaluate the rate of preterm birth and low birth weight in neonates having postnatal respiratory failure. Methods: A cross-sectional design was used in the study. There were 139 neonates with postnatal respiratory failure and 278 neonates without respiratory failure included in the study. Data on comorbidities, gestational age, and mechanical ventilation status were collected. Results: Among neonates with respiratory failure, the rate of preterm birth (< 37 weeks) was 70.5%. The average gestational age and weight of the respiratory failure group were significantly lower compared to the control group (p < 0.001). Asphyxia, patent ductus arteriosus, and hyaline membrane were the most common causes of respiratory failure. The rate of neonates having less than 37 gestational weeks and requiring mechanical ventilation as treatment for respiratory failure was 73.5%, in which the proportion of neonates born before 32 gestational weeks was 47.1% (p < 0.001). Conclusion: The rates of preterm birth and low birth weight among infants with respiratory failure in a tertiary hospital in Vietnam were significantly high. Causes of preterm birth and low birth weight were preventable and treatable if having appropriate care and treatment plan.
Taxonomy of the Linum perenne group in Europe

A new taxonomic treatment of the Linlltn perellne group in Europe is presented, based on a detailed biosystematic study. L. alpinulII Jacq. , L. extraaxillare Kit. and L. montanlltn Schleicher ex DC. are treated as subspecies of L. perenlle L. , and L. collinlltn Guss. as a subspecies of L. allstriaCUIII L. Previous confusion between L. perelllle subsp. anglicllfll (Miller) Ockendon and L. leollii Schultz has been resolved. The morphological variation within each subspecies is described and interpreted in terms of its distribution. Most of the morphological characters which have been used in the past have proved to be taxonomically unreliable because they vary almost continuously within the group and show considerable phenotypic plasticity. Chromo­ some number, heterostyly and pollen characters are taxonomically more reliable than the quantitative morphological characters. The pattern of variation within the L. perenne group is discussed in relation to its rarity, disjunct distribution, ecology and breeding system.
Efficacy of buparavaquone in the treatment of bovine benign theileriosis

The aim of the study was to assess the effectiveness of the buparvaquone in cattle with theileriosis. The study revealed, most of the animals suffer from subclinical or chronic form of theileriosis, which is caused by Theileria orientalis conformed by PCR. Bovine benign theileriosis (BBT) is a mild or subclinical form of disease, which is indicated by the clinical signs and severe anemic haemogram. Inj. Buparavaquone @ 2.5 mg/kg body weight by intramuscular route as single dose has effectively reduced the clinical signs and also improved the heamatology, serum biochemistry and also effectively removed the Theileria orientalis organism from the circulatory system of the animals in 21days post treatment and showed 100% recovery.
The Impact of Prudential Regulation on Jordanian Banks Liquidity

Regulation of the financial sector is major aspect of consideration by the regulating authority, since financial sector highly influences the performance of the entire economy. The Global Financial Crises underlined the importance of liquidity management,when the credit crisis led to a liquidity crisis. Thus, Jordanian regulatory authorities are trying to achieve and maintain the financial stability by assessment of the banks’ financial condition and through regulations that ensure the stability and prevent failures that can occur under adverse circumstances. The study aim to analyze the impact of a prudential regulation on the Jordanian Banks liquidity. The specific objective in this case is; to determine whether the current prudential regulation enhance the banks liquidity in Jordan, or financial regulation still need additional updates. This study examines the impact of both Microprudential and Macroprudential regulation on Banks Liquidity Ratio, within the context of the Jordanian Banking Sector. To carry out the analysis, managed to collect the annual data for 12 listed during the period 2005-2018 with data arranged in the form of a panel, by using Random Effect Approach Regression, and compared the bank liquidity ratios during period before and after Global Financial Crisis (2008). The results indicate that Macroprudential tools have positive significant impact on Banks Liquidity Ratio, while micro is not. The main conclusions from this research indicate that while liquidity requirements tend to reduce liquidity risk, it appear to be more costly to comply with, reduced bank liquidity, and the banking sector still need additional Regulation updates to enhance banks Liquidity.
Developing empathy in the academic design studio: conclusions from an empirical study in graduate and undergraduate programs in industrial design

This paper presents the conclusions of an empirical study aimed at (1) identifying educational practices in the academic design studio intended to promote empathy in industrial design students, and (2) identifying a broad range of expressions of student empathy for users and stakeholders. The study was motivated by the importance that current human-centered design approaches give to empathy as an ability required to understand and connect with users and by the little empirical research that examines empathy development in design education. Methodologically, a mixed methods strategy was used to collect and analyze data from faculty and students in three undergraduate and graduate courses in industrial design offered by a major land-grant public research university in the southeastern United States. The findings of the study consisted of identifying strategies used by faculty to promote empathy in the design studio and categories of students’ expressions of empathy. These findings informed the conclusions herein presented as recommendations for educators to promote student empathy in their design courses. Author
Analysis of a phobia in a five-year-old boy

(a) GERMAN EDITIONS: 1909 Jb. psychoanal. psychopath. Forsch. , 1 (1), 1-109. 1913 S.K. S.N. , III, 1-122 (1921, 2nd. ed.). 1924 G.S. , 8, 129-263. 1932 Vier Krankengeschichten, 142-281. 1941 G.W. , 7, 243-377. 1922 ‘Nachschrift zur Analyse des kleinen Hans’, Int z. Psychoanal. , 8 (3), 321. 1924 G.S. , 8, 264-5. 1932 Vier Krankengeschichten, 282-3. 1940 G.W. , 13, 431-2. (b) ENGLISH TRANSLATION: ‘Analysis of a Phobia in a Five-Year-Old Boy’ 1925 C.P., 3, 149-287—‘Postscript (1922)’, Standard Ed., 288-9. (Tr. Alix and James Strachey.) The present translation is a reprint, with some alterations and additional notes, of the English version first published in 1925. Some records of the earlier part of little Hans's life had already been published by Freud two years before, in his paper on ‘The Sexual Enlightenment of Children’ (1907c). In the earlier editions of that paper, however, the boy was
From Consensus to Conflict: Understanding Foreign Measures Targeting U.S. Elections

Russia might try to manipulate and divide U.S. voters via social media during the U.S. political campaign season of 2020. RAND researchers sought to analyze, forecast, and mitigate threats by foreign actors targeting local, state, and national elections. This report, the first of four in a series, reviews some of the research on information efforts by foreign actors, focusing mainly on Russia and online environments.
Assessing Financial Market Integration in Vietnam: A Price – Based Approach

This paper investigates the existence of financial market integration between Vietnam and the region (ASEAN, ASIAN) as well as the world using price-based indicators. Our paper is the first to assess the overall integration of the Vietnam financial market based on two different datasets for different sub-capital markets, the bond market and stock market, during the period of 2009 - 2018. The empirical results show that Vietnam, compared to other countries in research, holds lower regional and international integration levels in both the bond market and the stock market, but demonstrates considerably strong signs of progressing regional and global stock market integration over the period. Especially, the absolute values estimated from the beta coefficient and beta convergence approaches for the Vietnamese stock market are larger than for the bond market, proving better convergence degree and speed of Vietnamese stock market over the bond market. These bring policymakers and regulators new thoughts and more challenges in designing appropriate policies towards the development of the financial markets in the future.