Miracle-dz/UniFAR-FTUs huggingface dataset:
EVALUASI ATAS IMPLEMENTASI APLIKASI SISTEM AKUNTANSI INSTANSI BASIS AKRUAL (SAIBA) PADA MITRA KERJA KPPN GORONTALO DAN MARISA

The purpose of this research is to evaluate the success of accrual basic application system (SAIBA) implementation based on user perception with DeLone & McLean (DM) Information System (IS) Success Model Approach. The data used are primary and secondary data. Primary data gathered through questionnaires distributed to respondents while secondary data gathered from other institutions such as Directorate General of Budget, Directorate General of Treasury, and Treasury Office of Gorontalo and Marisa. This model uses six variables which are system quality, information quality, user satisfaction, use, individual impact and organizational impact. This research empirically showed that the accrual basic application system (SAIBA) currently implementated not successfully running yet based on all Delone and McLeanâ€™s success measurement criterias. Abstrak Penelitian ini bertujuan untuk mengevaluasi sejauh mana keberhasilan implementasi aplikasi SAIBA yang telah berjalan selama ini berdasarkan sudut pandang pengguna (user) dengan menggunakan pendekatan Delone & McLean Information System Success Model. Sumber data yang digunakan dalam penelitian ini berasal dari data primer dan data sekunder. Data primer berupa data yang diperoleh langsung dari responden melalui kuesioner yang dibagikan. Sedangkan data sekunder adalah data yang diperoleh dan disajikan oleh pihak-pihak lainnya seperti Direktorat Jenderal Anggaran Kementerian Keuangan, Direktorat Jenderal Perbendaharan Negara Kementerian Keuangan, dan Kantor Pelayanan Perbendaharaan Negara (KPPN) Gorontalo dan Marisa. Model ini menggunakan enam variabel pengukuran yaitu Â kualitas Â sistem (system quality), kualitas informasi (information quality), kepuasan pengguna (user satisfaction), penggunaan sistem (use), dampak individu (individual impact) dan dampak organisasi Â (organizational impact). Penelitian membuktikan secara empiris bahwa implementasi aplikasi SAIBA belum berjalan sukses berdasarkan kriteria pengukuran sesuai model kesuksesan DeLone dan McLean Â (1992).
Bioinformatics tools for the analysis of macromolecular structures

Bioinformaticke nastroje pro analýzu makromolekularnich struktur Pocitacova analýza biopolymerů a predikce jejich vlastnosti jsou důležite pro při jejich výzkumu a biotechnologickem využiti. Tato dizertacni prace popisuje nove algoritmy a metody pro analýzu struktury a funkce biopolymerů. Volne prostory uvnitř makromolekularnich struktur casto maji důležitou funkci, jako vazat male molekuly nebo sloužit k jejich transportu do nebo z vazebneho mista. Byla vytvořena nova metoda pro analýzu transportnich cest v makromolekulach. Identifikace cest je založena na Voroneho diagramu. Dale bylo použito shlukovani pro nalezeni sobě odpovidajicich cest nalezených v různých strukturach, což umožňuje zkoumat vývoj jejich vlastnosti v case. Pro analýzu velkých množstvi struktur byla vyvinuta nova aproximace aglomerativniho shlukovani metodou průměrne vzdalenosti. Dale byly vyvinuty algoritmy algoritmy pro měřeni objemu maleho omezeneho prostoru v dynamických strukturach. Analýza volných prostorů s funkcnim významem byla take použita v plně automatizovane výpocetni metodě pro identifikaci pozic v enzymu jejichž mutace se zvýsenou pravděpodobnosti povede ke vzniku enzymu nových vlastnosti. Na zakladě těchto metod byly vyvinuty softwarove nastroje CAVER 3.0, CAVER Analyst a HotSpot Wizard. Nastroje jsou volně ke staženi. Jsou hojně využivany a jim odpovidajici metodicke publikace byly citovany vice než 140×.
An aerial/ground robot team for autonomous firefighting in urban GNSS-denied scenarios

This paper presents a framework for urban firefighting with a heterogeneous aerial/ground robot team. The system was developed to address Challenge 3 of the MBZIRC’20. The challenge required autonomously detecting, locating, and extinguishing fires on multiple interior floors and on exterior facade and ground surfaces. Our multi-robot system consists of a robot team of up to three Unmanned Aerial Vehicles (UAV) and one Unmanned Ground Vehicle (UGV). We describe the main hardware and software components for UAV and UGV platforms and present the system’s main algorithmic components: a 3D LIDAR-based Mapping and Localization module able to work in GPS-denied scenarios, a Global Planner and a fast local re-planning system for robot navigation, Infrared-Based Perception and robot actuation control for fire extinguishing, and Mission Executive and coordination module based on Behavior Trees. Finally we describe our results from the competition, where the system worked fully autonomously and scored in all the trials performed. The presented system ended in 7 th place (out of 20 teams) in Challenge 3 and 5 th place (out of 17 teams) in the Grand Challenge’s Challenge 3 portion.
Hemodynamic efficacy of a motor-driven automatic device performing simultaneous sternothoracic cardiopulmonary resuscitation compared to standard cardiopulmonary resuscitation in an animal model of cardiac arrest

*Correspondence shwang@yonsei.ac. kr (Sung Oh Hwang) Abstract The aim of this study was to investigate hemodynamic effects and resuscitation outcomes of simultaneous sternothoracic cardiopulmonary resuscitation (SST-CPR)with a prototype of a motor-driven automatic device, comparing to manual standard CPR (SCPR), in an animal model of ventricular fibrillation (VF). 20 male pigs were randomized to receive standard CPR (S-CPR group) or CPR with an automatic SST-CPR device (A-CPR group) after 5 minutes of VF. Five minutes of basic life support CPR was performed, followed by 10 minutes of advanced life support CPR. Hemodynamic variables including systolic blood pressure (SBP), diastolic blood pressure (DBP), coronary perfusion pressure (CPP), and end-tidal carbon dioxide tension (ETCO2), and resuscitation outcomes including rate of restoration of spontaneous circulation (ROSC) and 2-hour survival were compared between two groups. Ten animals among the A-CPR group and 8 animals among the S-CPR group were included in the final analysis. SBP was higher in the A-CPR group than in the S-CPR group during CPR (p = 0.046). The DBP, CPP and ETCO2 were not different between two groups (p = 0.412, 0.585, and 0.243, respectively). ROSC rate was 38% in the S-CPR group and 10% in the A-CPR group (p = 0.275). The 2-hour survival rate was 25% in the S-CPR group and 0% in the A-CPR group (p = 0.183). In a swine model of cardiac arrest, CPR with a prototype of a motor-driven automatic SST-CPR device, compared with standard CPR, produced higher systolic blood pressure, but there was no difference in diastolic pressure, coronary perfusion pressure, ROSC rate and 2-hour survival rate.
(Z)-Endoxifen and Early Recurrence of Breast Cancer: An Explorative Analysis in a Prospective Brazilian Study

Adherence to treatment and use of co-medication, but also molecular factors such as CYP2D6 genotype, affect tamoxifen metabolism, with consequences for early breast cancer prognosis. In a prospective study of 149 tamoxifen-treated early-stage breast cancer patients from Brazil followed up for 5 years, we investigated the association between the active tamoxifen metabolite (Z)-endoxifen at 3 months and event-free survival (EFS) adjusted for clinico-pathological factors. Twenty-five patients (16.8%) had recurred or died at a median follow-up of 52.3 months. When we applied a putative 15 nM threshold used in previous independent studies, (Z)-endoxifen levels below the threshold showed an association with shorter EFS in univariate analysis (p = 0.045) and after adjustment for stage (HR 2.52; 95% CI 1.13–5.65; p = 0.024). However, modeling of plasma concentrations with splines instead of dichotomization did not verify a significant association with EFS (univariate analysis: p = 0.158; adjusted for stage: p = 0.117). Hence, in our small exploratory study, the link between impaired tamoxifen metabolism and early breast cancer recurrence could not be unanimously demonstrated. This inconsistency justifies larger modeling studies backed up by mechanistic pharmacodynamic analyses to shed new light on this suspected association and the stipulation of an appropriate predictive (Z)-endoxifen threshold.
“There Are Things We Can Do and There Are Things We Cannot Do.” A Qualitative Study About Women's Perceptions on Empowerment in Relation to Fertility Intentions and Family Planning Practices in Mozambique

Introduction The restrictive socio-cultural norms in Mozambique limit the power of women to decide, voice, and act on their reproductive choices. This study aimed to explore women's perceptions and experiences of empowerment relating to fertility intentions and family planning practices in Mozambique, focusing on facilitators and barriers toward reproductive empowerment. Methods Qualitative in-depth interviews were undertaken with women of reproductive age (18–49 years) in Nampula and Maputo provinces and Maputo city, Mozambique. Data collection took place between February and March 2020 in Maputo region and during August 2020 in Nampula Province. Convenience sampling was used to recruit participants from both urban and rural healthcare facilities and from within the communities serving the healthcare facilities. In Maputo city, a snowball sampling technique was used to recruit women from the community. A total of 64 women were interviewed, 39 from Maputo and 25 from Nampula. A thematic analysis was conducted with the support of NVivo12 software. Results Several factors that hinder and facilitate women's empowerment toward fertility and family planning practices in Mozambique were identified and were interpreted within the socio-ecological model. The identified barriers included women's lack of critical consciousness and oppressive relationships. At the community and societal levels, the role of traditions, culture and gender expectations and limited access to family planning and misinformation were also important hindering factors. The facilitators of reproductive empowerment included building critical consciousness and access to economic resources at the individual level. Negative experiences at the household level were triggers of women's empowerment for family planning. Building collective power and access to information, including education, were key at the community and societal levels. Conclusions This study identified various factors that positively or negatively influence women's empowerment journeys in Mozambique. The role of tradition, culture, and gender expectations, and oppressive relationships, were important barriers in both provinces. Women from rural areas would benefit from building of consciousness about their rights, and power to decide on their reproductive lives. Interactions with the health providers offer an opportunity to do this by favoring controlling behaviors concerning their reproductive lives, promoting social networking and levering collective power.
Selection Signatures of Pacific White Shrimp Litopenaeus vannamei Revealed by Whole-Genome Resequencing Analysis

The Pacific white shrimp Litopenaeus vannamei is among the top aquatic species of commercial importance around the world. Over the last four decades, the breeding works of L. vannamei have been carried out intensively and have generated multiple strains with improved production and performance traits. However, signatures of domestication and artificial selection across the L. vannamei genome remain largely unexplored. In the present study, we conducted whole genomic resequencing of 180 Pacific white shrimps from two artificially selective breeds and four market-leading companies. A total of 37 million single nucleotide polymorphisms (SNPs) were identified with an average density of 22.5 SNPs/Kb across the genome. Ancestry estimation, principal component analysis, and phylogenetic inference have all revealed the obvious stratifications among the six breeds. We evaluated the linkage disequilibrium (LD) decay in each breed and identified the genetic variations driven by selection. Pairwise comparison of the fixation index (Fst) and nucleotide diversity (θπ) has allowed for mining the genomic regions under selective sweep in each breed. The functional enrichment analysis revealed that genes within these regions are mainly involved in the cellular macromolecule metabolic process, proteolysis, structural molecule activity, structure of the constituent ribosome, and responses to stimulus. The genome-wide SNP datasets provide valuable information for germplasm resources assessment and genome-assisted breeding of Pacific white shrimps, and also shed light on the genetic effects and genomic signatures of selective breeding.
Cognitive and Global Functioning in Patients With First-Episode Psychosis Stratified by Level of Negative Symptoms. A 10-Year Follow-Up Study

Negative and cognitive symptoms are core features of schizophrenia that are correlated in cross-sectional designs. To further explore the relationship between these critical symptom dimensions we use a method for stratifying participants based on level and persistence of negative symptoms from absent to sustained levels over a 10-year follow-up period. We investigate associations with cognitive performance and level of global functioning. First-episode psychosis (FEP) participants (n = 102) and healthy controls (n = 116) were assessed at baseline and follow-up. A cognitive battery consisting of 14 tests derived into four domains and a composite score were used in the analyses. FEP participants were stratified based on negative symptom items from the Positive and Negative Syndrome Scale (PANSS-R) into four groups with either no, mild, transitory or sustained symptoms over the 10-year follow-up period. Global functioning was measured with Global Assessment of Functioning Scale-Split version. Multivariate and univariate analyses of variance were used to explore between-group differences in level and course of cognitive performance as global functioning. A multivariate analysis with four cognitive domains as dependent variables, showed significant group differences in performance when including healthy controls and the negative symptom groups. The groups with no and mild negative symptoms outperformed the group with sustained levels of negative symptoms on verbal learning and memory. The group with no negative symptoms also outperformed the group with sustained negative symptoms on the cognitive composite score. Significant improvements on verbal learning and memory, executive functioning and the cognitive composite were detected for the entire sample. No differences in cognitive course were detected. There was a significant improvement in global functioning as measured by the GAF-F over the follow-up period (p < 0.001), without any time x group interactions (p = 0.25). Participants with sustained negative symptoms had a significantly lower level of global functioning at 10-year follow-up with an additional independent effect of the cognitive composite score, compared to all other groups. Individuals with an early illness course characterized by absence of negative symptoms form a group with better cognitive and functional outcomes than the impairments typically associated with schizophrenia. Individuals with sustained levels of negative symptoms on the other hand may require a combined focus on both negative and cognitive symptoms.
Use of Functional MRI in Deep Brain Stimulation in Parkinson's Diseases: A Systematic Review

Deep brain stimulation (DBS) has been used to modulate aberrant circuits associated with Parkinson's disease (PD) for decades and has shown robust therapeutic benefits. However, the mechanism of action of DBS remains incompletely understood. With technological advances, there is an emerging use of functional magnetic resonance imaging (fMRI) after DBS implantation to explore the effects of stimulation on brain networks in PD. This systematic review was designed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to summarize peer-reviewed articles published within the past 10 years in which fMRI was employed on patients with PD-DBS. Search in PubMed database provided 353 references, and screenings resulted in a total of 19 studies for qualitative synthesis regarding study designs (fMRI scan timepoints and paradigm), methodology, and PD subtypes. This review concluded that fMRI may be used in patients with PD-DBS after proper safety test; resting-state and block-based fMRI designs have been employed to explore the effects of DBS on brain networks and the mechanism of action of the DBS, respectively. With further validation of safety use of fMRI and advances in imaging techniques, fMRI may play an increasingly important role in better understanding of the mechanism of stimulation as well as in improving clinical care to provide subject-specific neuromodulation treatments.
Addressing COVID-19 Testing Inequities Among Underserved Populations in Massachusetts: A Rapid Qualitative Exploration of Health Center Staff, Partner, and Resident Perceptions

Introduction Access to COVID-19 testing has been inequitable and misaligned with community need. However, community health centers have played a critical role in addressing the COVID-19 testing needs of historically disadvantaged communities. The aim of this paper is to explore the perceptions of COVID-19 testing barriers in six Massachusetts communities that are predominantly low income and describe how these findings were used to build tailored clinical-community strategies to addressing testing inequities. Methods Between November 2020 and February 2021, we conducted 84 semi-structured qualitative interviews with 107 community health center staff, community partners, and residents. Resident interviews were conducted in English, Spanish, Vietnamese, and Arabic. We used a 2-phase framework analysis to analyze the data, including deductive coding to facilitate rapid analysis for action and an in-depth thematic analysis applying the Social Ecological Model. Results Through the rapid needs assessment, we developed cross-site suggestions to improve testing implementation and communications, as well as community-specific recommendations (e.g., locations for mobile testing sites and local communication channels). Upstream barriers identified in the thematic analysis included accessibility of state-run testing sites, weak social safety nets, and lack of testing supplies and staffing that contributed to long wait times. These factors hindered residents' abilities to get tested, which was further exacerbated by individual fears surrounding the testing process and limited knowledge on testing availability. Discussion Our rapid, qualitative approach created the foundation for implementing strategies that reached underserved populations at the peak of the COVID-19 pandemic in winter 2021. We explored perceptions of testing barriers and created actionable summaries within 1–2 months of data collection. Partnering community health centers in Massachusetts were able to use these data to respond to the local needs of each community. This study underscores the substantial impact of upstream, structural disparities on the individual experience of COVID-19 and demonstrates the utility of shifting from a typical years' long research translation process to a rapid approach of using data for action.
High on/off capacitance ratio RF MEMS capacitive switches

In this paper, high on/off capacitance ratio radio frequency micro-electro-mechanical-systems (RF MEMS) switches are designed, fabricated, measured and analyzed. Two types of RF MEMS switches, a shunt switch with a contact point and an inline switch without a contact point, are presented. Metal–insulator–metal (MIM) fixed capacitors are used in the MEMS switches. The electrode topologies of RF MEMS switches are analyzed. The parameter λ is defined to describe the relationship between the capacitance ratio, the height of the beam and the actuation voltage. The measured results indicate that, for MEMS switch #1 with a contact point and gap of 1 µm, the insertion loss is better than 0.64 dB up to 40 GHz, and the isolation is more than 20 dB from 11.28 to 30.38 GHz with an actuation voltage of 42 V. For the inline MEMS with a displacement of 1.5 µm, the insertion loss is better than 0.56 dB up to 40 GHz, and the isolation is more than 20 dB from 4.45 to 30.48 GHz with an actuation voltage of 36 V. Circuit models and measured results of the proposed MEMS switches show good agreement. From the fitted results, the on/off capacitance ratio is ~227 for the MEMS switch #1 and ~313 for the MEMS switch #2, respectively. Compared with traditional MEMS capacitive switches with dielectric material Si3N4 and a relatively lower gap (1.5 µm), the proposed MEMS switches exhibit high on/off capacitance ratios.
Extracellular Vesicles From Microalgae: Uptake Studies in Human Cells and Caenorhabditis elegans

Extracellular vesicles (EVs) are lipid membrane nano-sized vesicles secreted by various cell types for intercellular communication, found in all kingdoms of life. Nanoalgosomes are a subtype of EVs derived from microalgae with a sustainable biotechnological potential. To explore the uptake, distribution and persistence of nanoalgosomes in cells and living organisms, we separated them from a culture of the chlorophyte Tetraselmis chuii cells by tangential flow filtration (TFF), labelled them with different lipophilic dyes and characterized their biophysical attributes. Then we studied the cellular uptake of labelled nanoalgosomes in human cells and in C. elegans, demonstrating that they enter the cells through an energy dependent mechanism and are localized in the cytoplasm of specific cells, where they persist for days. Our data confirm that nanoalgosomes are actively uptaken in vitro by human cells and in vivo by C. elegans cells, supporting their exploitation as potential nanocarriers of bioactive compounds for theranostic applications.
Subsidence Induced by Gas Extraction: A Data Assimilation Framework to Constrain the Driving Rock Compaction Process at Depth

Surface movement can be induced by many human subsurface activities: production of natural gas, geothermal heat extraction, ground water extraction, phreatic groundwater level lowering, storage of natural gas and CO2. In this manuscript, we focus on subsidence caused by gas production. While geological interpretations, seismic campaigns and flow modeling often provide a relatively rich pre-existing knowledge, understanding of the driving mechanisms for production-induced subsidence is still poor and forecasts are often very uncertain. This is related to the multiple poorly constrained models that translate gas production to ground surface displacements. Currently, a biased constraint of these models is inferred by arbitrarily pre-selecting a subset of those. Here, we have devised and deployed an integrated approach of the entire chain of models from the flow simulations to the ground surface displacements which, for the first time, accounts for all our pre-existing knowledge in terms of processes and uncertainties attached to them. More specifically for the transfer between reservoir depletion to compacting volume at depth, four reservoir-rock compaction models are a-priori considered, ranging from linear elastic model to nonlinear time-dependent viscous-type model. After assimilation of the geodetic observations (i.e., the ground-surface displacements) with ensemble-smoother algorithms, we demonstrate that even when all the a-priori known complexities were present in all steps of the modelling chain, the model parameter uncertainties of each model could be reduced. Interestingly we demonstrate that one can discriminate which reservoir-rock compaction model driving subsidence is activated at depth. This identification of the activated compaction model at depth is crucial to build confidence in our subsidence forecasts. The predictive power of the integrated approach is demonstrated with an ensemble of synthetic but complex reservoir flow simulations mimicking all the characteristics and uncertainties representative for real gas fields in the north of the Netherlands.