Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluating Environmental Sounds from a Presence Perspective for Virtual Reality Applications

We propose a methodology to design and evaluate environmental sounds for virtual environments. We propose to combine physically modeled sound events with recorded soundscapes. Physical models are used to provide feedback to users' actions, while soundscapes reproduce the characteristic soundmarks of an environment. In this particular case, physical models are used to simulate the act of walking in the botanical garden of the city of Prague, while soundscapes are used to reproduce the particular sound of the garden. The auditory feedback designed was combined with a photorealistic reproduction of the same garden. A between-subject experiment was conducted, where 126 subjects participated, involving six different experimental conditions, including both uni- and bimodal stimuli (auditory and visual). The auditory stimuli consisted of several combinations of auditory feedback, including static sound sources as well as self-induced interactive sounds simulated using physical models. Results show that subjects' motion in the environment is significantly enhanced when dynamic sound sources and sound of egomotion are rendered in the environment.
Digital Cardiac Rehabilitation Programs: The Future of Patient-Centered Medicine.

BACKGROUND The low participation rate in cardiac rehabilitation programs is the major reason for rehospitalization, morbidity, and mortality. Home-based cardiac rehabilitation by technological means is an essential component of a "patient-centered" approach, which is capable of enhancing the participation rate in rehabilitation programs. INTRODUCTION The aim of this research was to examine attitudes, perceptions, and behavioral intentions toward remote digital cardiac rehabilitation (RDCR) with respect to factors such as age, education, smoking, exercise habits, technological illiteracy, and mobile phone behavior. MATERIALS AND METHODS This was a cross-sectional study of 200 adult patients discharged from a hospital after an acute coronary syndrome, cardiac surgery, or percutaneous coronary intervention. All patients answered an anonymous Technology Usage Questionnaire, which examined the relationship between their willingness to participate in the RDCR program and various parameters. The surveys were distributed and completed between July 2017 and November 2017 at the Sheba Medical Center in Israel. RESULTS Overall, 83% of all participants were interested in participating in the RDCR program. Those with heart failure had a greater interest in the program (100%; p < 0.05), whereas patients after coronary bypass surgery had a lesser interest (71.1%; p < 0.05). The level of attitude toward healthy lifestyle was found to be a significant predictor of willingness to participate in RDCR (odds ratio 2.26; p = 0.01). Sociodemographic characteristics, lifestyle, habits, technological knowledge, age, and gender were not found as significant predictors of interest in RDCR. CONCLUSIONS The RDCR program was acceptable to most cardiac patients, including the elderly population, and could be a potential solution for patients who avoid traditional rehabilitation programs in medical centers.
Individual- versus group-optimality in the production of secreted bacterial compounds

How unicellular organisms optimize the production of compounds (enzymes and metabolites) is a fundamental biological question. While it is typically thought that this production is optimized at the individual cell level, we examine whether it can also be optimized at the group level instead, through specialization, where a fraction of cells secretes and shares compounds with the other group members. Using mathematical modeling, we show that within-group division of labor is promoted if (1) the per-compound production costs diminish with higher production volumes, and (2) compound sharing is sufficiently high. Experiments with pyoverdine, a shareable compound secreted by Pseudomonas aeruginosa, indeed revealed diminishing costs, yet instead of dividing labor, all cells engage in pyoverdine production. We conclude that even when diminishing costs ostensibly favor phenotypic specialization, its evolution can either be hindered by factors limiting reliable compound sharing in the natural environment or mechanistic constraints impeding stochastic or signal-induced heterogeneity to arise. Thus, shifts in the level of selection, from individuals to groups, might be restricted in loose microbial groups.
Racial/ethnic disparities in women's sleep duration, continuity, and quality, and their statistical mediators: Study of Women's Health Across the Nation.

STUDY OBJECTIVES To describe racial/ethnic differences in sleep duration, continuity, and perceived sleep quality in postmenopausal women and to identify statistical mediators of differences in sleep characteristics. METHODS Recruited from the observational Study of Women's Health Across the Nation (SWAN), 1,203 (548 white, 303 black, 147 Chinese, 132 Japanese, and 73 Hispanic; mean age 65 years, 97% postmenopausal) women participated in a week-long actigraphy and daily diary study in 2013-2015. Actigraphic measures of sleep duration and wake after sleep onset (WASO), and diary-rated sleep quality were averaged across the week. Candidate mediators included health-related variables; stress; and emotional well-being assessed up to 13 times across 18 years from baseline to sleep study. RESULTS Whites slept longer than other groups; the significant mediators were concurrent financial hardship and increasing number of stressors for Hispanics or Japanese versus whites. Whites had less WASO than blacks and Hispanics; significant mediators were concurrent number of health problems, physical inactivity, waist circumference, vasomotor symptoms, number of life stressors, and financial hardship, and increasing number of health problems from baseline to sleep study. Whites reported better sleep quality than blacks, Chinese, and Japanese; significant mediators were concurrent physical inactivity, vasomotor symptoms, positive affect, and depressive symptoms. CONCLUSIONS Sleep differences between blacks or Hispanics versus whites were mediated by health problems, number of stressors, and financial hardship, whereas sleep differences between Chinese or Japanese versus whites were mediated by emotional well-being. This is the first study using formal mediational approaches.
Intrinsic Functional Brain Connectivity Predicts Onset of Major Depression Disorder in Adolescence: A Pilot Study

Children with familial risk for major depressive disorder (MDD) have elevated risk for developing depression as adolescents. Here, we investigated longitudinally whether resting-state functional connectivity (RSFC) could predict the onset of MDD. In this pilot study, we followed a group of never-depressed children with familial risk for MDD and a group of age-matched controls without familial risk who had undergone an MRI study at 8-14 years of age. Participants were reassessed 3-4 years later with diagnostic interviews. We first investigated group differences in RSFC from regions in the emotion regulation, cognitive control, and default mode networks in the children who later developed MDD (converted), the children who did not develop MDD (nonconverted), and the control group. We then built a prediction model based on baseline RSFC that was independent of the group differences to classify the individuals who later developed MDD. Compared with the nonconverted group, the converted group exhibited hypoconnectivity between subgenual anterior cingulate cortex (sgACC) and inferior parietal lobule (IPL) and between left and right dorsolateral prefrontal cortices. The nonconverted group exhibited higher sgACC-IPL connectivity than did both the converted and control groups, suggesting a possible resilience factor to MDD. Classification between converted and nonconverted individuals based on baseline RSFC yielded high predictive accuracy with high sensitivity and specificity that was superior to classification based on baseline clinical rating scales. Intrinsic brain connectivity measured in healthy children with familial risk for depression has the potential to predict MDD onset, and it can be a useful neuromarker in early identification of children for preventive treatment.
Outcomes in Burn-Injured Patients Who Develop Sepsis.

This study examines health outcomes in burn patients with sepsis. We hypothesized that burn patients with sepsis would have an increased odds risk for in-hospital death and longer intensive care unit (ICU) stays. This was a retrospective cohort of consecutive patients admitted to the burn ICU with total BSA (TBSA) ≥10% and/or inhalation injury between January 2008 and March 2015. Overall 407 burn patients were included; the case-rate for sepsis was 39.1% (n = 159); 20.1% (n = 82) patients were septic and 18.9% (n = 77) patients experienced septic shock. Patients with septic shock had the highest mortality rate (13.31% no sepsis vs 3.7% sepsis vs 49.4% septic shock, P < .01). Median 28-day ICU-free days was higher in patients without sepsis (23 days [Interquartile range (IQR) 14-27] no sepsis vs 0 days [IQR 0-10] sepsis vs 0 days [IQR 0-0] septic shock, P < . 01). Sepsis (with or without shock) increased odds of in-hospital death (odds ratio 7.04, 95% confidence interval 1.93-25.7) in reference to the no sepsis group. With each incremental Sequential Organ Failure Assessment (SOFA) score or 10% TBSA increase, the odds risk for in-hospital death increased by 56 and 75%, respectively. Our study characterized outcomes in patients with sepsis after severe burn injury. The odds risk for in-hospital death was greater in patients with sepsis, increasing burn severity according to TBSA and SOFA score.
Early Maladaptive Schemas and Social Information Processing in Child-to-Parent Aggression

The purpose of this longitudinal study was to assess the relationship between early maladaptive schemas (EMSs) and child-to-parent aggression (CPA) and to test whether social information processing (SIP) mediates this association. A total of 903 adolescents (50.9% girls) completed measures of EMSs at Time 1, SIP at Time 1 and Time 2 (1 year later), and CPA at Time 1, Time 2, and Time 3 (2 years later) to determine whether SIP measured at Time 2 mediated between the EMSs measured at Time 1 and CPA measured at Time 3. The results showed that each schema evaluated in this study had a different effect on SIP components and CPA. The SIP components of anger and aggressive response access in turn predicted CPA, mediating the relationship between two EMSs and CPA. More specifically, the schemas of defectiveness and the justification of violence predicted the response access component of SIP, which in turn predicted CPA. The results also showed bidirectional relationships between SIP components and CPA; whereas SIP components predicted CPA, the latter also predicted a worsening in SIP, perpetuating the problem. Furthermore, several gender differences were found in these paths. The findings indicate that intervention in the social-cognitive mechanisms is important to reduce adolescents’ aggression directed toward their parents.
The X Chromosome Is Necessary for Somatic Development in the Dioecious Silene latifolia: Cytogenetic and Molecular Evidence and Sequencing of a Haploid Genome

Silene latifolia (or white campion) possesses a well-established sex determination system with a dominant Y chromosome in males (the mammalian type). The heteromorphic sex chromosomes X and Y in S. latifolia largely stopped recombination; thus, we can expect a gradual genetic degeneration of the Y chromosome. It is well proven that neither diploid nor polyploid S. latifolia sporophytes can survive without at least one X, so the only life stage possessing the Y as the sole sex chromosome is the male gametophyte (pollen tube), while the female gametophyte seems to be X-dependent. Previous studies on anther-derived plants of this species showed that the obtained plants (largely haploid or dihaploid) were phenotypically and cytologically female. In this paper, we provide molecular evidence for the inviability of plants lacking the X chromosome. Using sex-specific PCR primers, we show that all plantlets and plants derived from anther cultures are female. In studying anther-derived diploid females by sequencing of X-linked markers, we demonstrate that these plants are really homozygous dihaploids. A haploid regenerant plant was sequenced (8× genome coverage) using Illumina technology. Genome data are disposable in the EMBL database as a standard for full genome and X chromosome assembly in this model species. Homozygous dihaploids were back-crossed with males to yield a progeny useful for the study of the evolution of the Y chromosome.
Social Integration, Self-Rated Health . . . and Genes?

Objective: This study examined genetic roots of later life social integration, and their confounding of this social factor’s health linkages. Method: Data were from the 2010 wave of the Health and Retirement Study. Two dimensions of integration were examined: with one’s “stakeholder” network of family and friends and with the community. Genetic measures included polygenic scores for extraversion and educational attainment. Results: Ties to one’s stakeholder network had no genetic associations. The extraversion polygenic score was linked to community integration among Blacks as well as Whites. Among the latter, the same was true of one’s genetic propensity for educational attainment. Although this score also influenced self-rated health, neither confounded associations of social integration with this indicator. Discussion: Later life social integration seems influenced by genetically rooted propensities for both sociability and human capital accumulation. Health linkages of integration, however, may not reflect mutual dependencies on the same genetic substrates.
Using a Mindfulness-Based Intervention to Support the Resiliency of In-Patient Pediatric Respiratory Therapists

BACKGROUND: Respiratory therapists (RTs) are care providers in highly stressful work environments with limited time and resources for self-care. Mindfulness-based interventions teach non-reactive awareness to the present situation or the ability to respond versus react in the moment, to shift away from a physical and emotional stress response. METHODS: Mindfulness-based group learning was offered during 2 regularly scheduled RT staff meetings for ∼30 min each session. Each meeting began and concluded with a distress assessment and with counting and recording respirations for 30 s. RESULTS: This quality-improvement project revealed mindfulness-based interventions to be feasible and acceptable. Mindfulness intervention reduced RT team members' physical and emotional stress related symptoms (as measured by a 1-point median decrease in the self-administered distress assessment, with P = .001 in session 1) and increased sense of calm (as measured by participant breathing rate decrease by mean of two-points P = .001 in session 1 and session 2). CONCLUSIONS: Mindfulness-based interventions were noted to be feasible and acceptable additions to RT staff meetings. These interventions have the potential to introduce breathing practices and mini mindfulness techniques.
Free-standing LiNi0.5Mn1.5O4/carbon nanofiber network film as lightweight and high-power cathode for lithium ion batteries.

Lightweight and high-power LiNi0.5Mn1. 5O4/carbon nanofiber (CNF) network electrodes are developed as a high-voltage cathode for lithium ion batteries. The LiNi0.5Mn1. 5O4/CNF network electrodes are free-standing and can be used as a cathode without using any binder, carbon black, or metal current collector, and hence the total weight of the electrode is highly reduced while keeping the same areal loading of active materials. Compared with conventional electrodes, the LiNi0.5Mn1. 5O4/CNF network electrodes can yield up to 55% reduction in total weight and 2.2 times enhancement in the weight percentage of active material in the whole electrode. Moreover, the LiNi0.5Mn1. 5O4/carbon nanofiber (CNF) network electrodes showed excellent current rate capability in the large-current test up to 20C (1C = 140 mAh/g), when the conventional electrodes showed almost no capacity at the same condition. Further analysis of polarization resistance confirmed the favorable conductivity from the CNF network compared with the conventional electrode structure. By reducing the weight, increasing the working voltage, and improving the large-current rate capability simultaneously, the LiNi0.5Mn1. 5O4/CNF electrode structure can highly enhance the energy/power density of lithium ion batteries and thus holds great potential to be used with ultrathin, ultralight electronic devices as well as electric vehicles and hybrid electric vehicles.
The genetic basis of drought tolerance in the high oil crop Sesamum indicum

Summary Unlike most of the important food crops, sesame can survive drought but severe and repeated drought episodes, especially occurring during the reproductive stage, significantly curtail the productivity of this high oil crop. Genome‐wide association study was conducted for traits related to drought tolerance using 400 diverse sesame accessions, including landraces and modern cultivars. Ten stable QTLs explaining more than 40% of the phenotypic variation and located on four linkage groups were significantly associated with drought tolerance related traits. Accessions from the tropical area harboured higher numbers of drought tolerance alleles at the peak loci and were found to be more tolerant than those from the northern area, indicating a long‐term genetic adaptation to drought‐prone environments. We found that sesame has already fixed important alleles conferring survival to drought which may explain its relative high drought tolerance. However, most of the alleles crucial for productivity and yield maintenance under drought conditions are far from been fixed. This study also revealed that pyramiding the favourable alleles observed at the peak loci is of high potential for enhancing drought tolerance in sesame. In addition, our results highlighted two important pleiotropic QTLs harbouring known and unreported drought tolerance genes such as SiABI4, SiTTM3, SiGOLS1, SiNIMIN1 and SiSAM. By integrating candidate gene association study, gene expression and transgenic experiments, we demonstrated that SiSAM confers drought tolerance by modulating polyamine levels and ROS homeostasis, and a missense mutation in the coding region partly contributes to the natural variation of drought tolerance in sesame.
Altered limbic and autonomic processing supports brain-heart axis in Takotsubo syndrome

Abstract Aims Takotsubo syndrome (TTS) is characterized by acute left ventricular dysfunction often triggered by emotional or physical stress. Severe activation of the sympathetic nervous system with catecholamine release caused by a dysfunctional limbic system has been proposed as a potential mechanism. We hypothesize that brain regions responsible for autonomic integration and/or limbic processing might be involved in the development of TTS. Here, we investigated alterations in resting state functional connectivity in TTS patients compared with healthy controls. Methods and results Using brain functional magnetic resonance imaging (fMRI), resting state functional connectivity has been assessed in 15 subjects with TTS and 39 healthy controls. Network-based statistical analyses were conducted to identify subnetworks with altered resting state functional connectivity. Sympathetic and parasympathetic networks have been constructed in addition to the default mode network and whole-brain network. We found parasympathetic- and sympathetic-associated subnetworks both showing reduced resting state functional connectivity in TTS patients compared with controls. Important brain regions constituting parasympathetic- and sympathetic-associated subnetworks included the amygdala, hippocampus, and insula as well as cingulate, parietal, temporal, and cerebellar regions. Additionally, the default mode network as well as limbic regions in the whole-brain analysis demonstrated reduced resting state functional connectivity in TTS, including the hippocampus, parahippocampal, and medial prefrontal regions. Conclusion For the first time, we demonstrate hypoconnectivity of central brain regions associated with autonomic functions and regulation of the limbic system in patients with TTS. These findings suggest that autonomic-limbic integration might play an important role in the pathophysiology and contribute to the understanding of TTS.
Willing to Work But Not to Wait: Individuals with Greater Alcohol Use Disorder Show Increased Delay Discounting Across Commodities and Less Effort Discounting for Alcohol

BACKGROUND Delay discounting refers to the devaluation of a reward given increasing delays to delivery. Similarly, effort discounting refers to the devaluation of a reward given increasing effort required to obtain it. Individuals with substance use disorder show higher rates of delay discounting, exacerbating short-term positive reinforcement at the expense of long-term consequences. This study explores how effort discounting compares to delay discounting behavior among alcohol users as well as how these preferences change between monetary and alcohol rewards. METHODS A total of 100 participants completed an online survey through Amazon Mechanical Turk. Participant alcohol use was evaluated using DSM-5 and the Alcohol Use Disorders Identification Test criteria. All participants completed 4 randomized discounting tasks involving delay or effort discounting, in which the reward was money or alcohol. A follow-up experiment (n = 423) added the alcohol purchase task to assess alcohol valuation. RESULTS Individuals with greater alcohol use disorder (AUD) severity discounted future money and alcohol significantly more than those with less AUD. However, individuals meeting more DSM-5 criteria were only willing to perform more effort for alcohol. The follow-up experiment replicated these findings and demonstrated that individuals with greater AUD also showed an increased valuation of alcohol and alcohol value-mediated effort discounting. CONCLUSIONS These results suggest that individuals with greater AUD were less willing to wait for money or alcohol. While all participants were willing to work for money regardless of AUD severity, individuals with greater AUD showed increased valuation of alcohol drinks and were willing to exert more effort to obtain alcohol. Together, these results paint a picture of individuals with increased AUD as both more impulsive and willing to work to obtain alcohol, contributing to our understanding of decision making among individuals who abuse substances.
Pilot: an operating system for a personal computer

The Pilot operating system provides a single-user, single language environment for higher level software on a powerful personal computer. Its features include virtual memory, a large “flat” file system, streams, network communication facilities, and concurrent programming support. Pilot thus provides rather more powerful facilities than are normally associated with personal computers. The exact facilities provided display interesting similarities to and differences from corresponding facilities provided in large multi-user systems. Pilot is implemented entirely in Mesa, a high-level system programming language. The modularization of the implementation displays some interesting aspects in terms of both the static structure and dynamic interactions of the various components.