Miracle-dz/UniFAR-FTUs huggingface dataset:
A live-attenuated influenza vaccine (LAIV) elicits enhanced heterologous protection when the internal genes of the vaccine are matched to the challenge virus

1 protection when the internal genes of the vaccine are matched to the 2 challenge virus 3 Andrew Smitha,b, Laura Rodrigueza*, Maya El Ghouayela, Aitor Nogalesa, Jeffrey M. 4 Chamberlaina, Katherine Sortinoa, Emma Reillya,c, Changyong Fengd, David J. 5 Tophama,c, Luis Martínez-Sobridoa, Stephen Dewhursta 6 7 aDepartment of Microbiology and Immunology, University of Rochester, Rochester, 8 New York; 9 bMedical Scientist Training Program (MSTP), University of Rochester, Rochester, 10 New York; 11 cDavid H. Smith Center for Vaccine Biology and Immunology, University of 12 Rochester, Rochester, New York; 13 dDepartment of Biostatistics and Computational Biology, 265 Crittenden Boulevard, 14 CU 420630, University of Rochester, Rochester, New York. 15 16 #address correspondence to Stephen Dewhurst 17 (Stephen_Dewhurst@urmc.rochester.edu) 18 19 *Current address: Agencia Española de Medicamentos y Productos Sanitarios, 20 Madrid, Spain. 21 Word Count = Abstract 250; Text 4487 22 Running Title: Internal genes contribute to protection by LAIV 23 JVI Accepted Manuscript Posted Online 20 November 2019 J. Virol. doi:10.1128/JVI.01065-19 Copyright © 2019 Smith et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Conceptualizing Green IS strategy

In this paper we develop a typology of Green IS strategies and address two research questions: 1) What different types of Green IS strategies can be identified in a real-life context? 2) How do firms with distinct Green IS strategies conceive the role of Green IS within their organization? We begin with the a priori definition of "Green IS strategy" and conduct an exploratory case study that examines multinational companies from different industries. Across these cases, four distinct Green IS strategies are identified as a result of a within-case analysis and the emerging patterns are more closely defined using a cross-case analysis. Insights are compared with extant literature and findings are consolidated in five propositions that outline characteristics of Green IS strategies. These propositions guide the conceptualization of a typology of Green IS strategies which illustrates four generic strategies: Green IS for Efficiency, for Innovation, for Transformation, and for Credibility.
OTT_A_205438 6843..6855

1Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, People’s Republic of China; 2Department of Oncology, The Affiliated Yixing Hospital of Jiangsu University, Yixing 214200, People’s Republic of China; 3Department of General Surgery, The Affiliated Yixing Hospital of Jiangsu University, Yixing 214200, People’s Republic of China; 4ICR Medical Affairs, ICON Plc, Shanghai 200003, People’s Republic of China; 5Cancer Center, TaiKang Xianlin Drum Tower Hospital, Nanjing University School of Medicine, Nanjing 210046, People’s Republic of China; 6Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing 210006, People’s Republic of China
The Use of Point-of-Care Bedside Lung Ultrasound Signiﬁcantly Reduces the Number of Radiographs and Computed Tomography Scans in Critically Ill Patients

BACKGROUND: Chest radiography has been reported to have low diagnostic accuracy in critically ill intensive care unit (ICU) patients, and chest computed tomography (CT) scans require patients to be transported out of the ICU, putting them at risk of adverse events. In this study we assessed the efﬁcacy of routine bedside lung ultrasound (LUS) in the evaluation of pleural effusions (PE) in the ICU. METHODS: Three hundred seventy-six patients admitted to the ICU for major trauma (46.3%), medical pathology (41.5%), and postsurgical complications (12.2%) (May 2008 to April 2009) were included in this study. Patients were placed into either the control group (group C) or the study group (group S), on the basis of the introduction of routine LUS performed by a single group of intensivists in 1 tertiary care ICU. To reduce provider bias, the physicians conducting the LUS were not aware of the study. Collected data included patient demographics, clinical course, and number of chest radiographs and CT scans performed. As a secondary goal, we assessed the reliability of Balik’s formula in PE estimation. RESULTS: No signiﬁcant differences were found between the 2 groups with regard to their demographics and ICU clinical course. Group S had a signiﬁcant reduction in the total number of chest radiographs obtained ( (cid:1) 26%; P (cid:2) 0.001) and CT scans ( (cid:1) 47%; P (cid:2) 0.001) in comparison with the comparison group C. A 6-month follow-up analysis of the ICU LUS protocol revealed a time-dependent decrease in the number of radiological examinations requested for patients with PE. Lastly, PE volume estimation using the LUS and Balik’s formula correlates well with the effective volume drained ( r (cid:3) 0.65; P (cid:2) 0.0001). CONCLUSIONS: Routine use of LUS in the ICU setting can be associated with a reduction of the number of chest radiographs and CT scans performed. (Anesth Analg 2010;111:687–92) ill
ArticleInvestigation of Wettability

In this study, we report on the investigation of influence of air atmospheric pressure dielectric barrier discharge on polyimide (Kapton) films. It is shown that plasma treatment causes a significant increase of Kapton wettability that is connected with alterations of its chemical composition (oxidation) induced by dielectric barrier discharge. Observed variations in the wettability of Kapton were also found to be accompanied by changes in the dynamics of water droplets drying on plasma-treated Kapton, namely by the reduction of the constant contact angle phase of the droplet drying. This effect may be ascribed to the higher surface heterogeneity of plasma-treated Kapton that causes pinning of the edges of drying droplet on the Kapton surface. Finally, the differences in wettability induced by the plasma treatment led to a different way, how the water condensates on the Kapton surface: while the condensing water forms large amount of small droplets on untreated Kapton, much bigger water structures were found on the Kapton exposed to atmospheric plasma.
PPA_A_320242 2577..2586

1Sanofi, Chilly-Mazarin, France; 2Centre de recherche en epidémiologie et santé des populations (CESP), INSERM U1018, Paris, France; 3Upper Airways Research Laboratory, Ghent University, Ghent, Belgium; 4CLINTEC, Karolinska Institutet, Stockholm, Sweden; 5Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, Universitat de Barcelona; Clinical and Experimental Respiratory Immunoallergy, IDIBAPS; and CIBERES, Barcelona, Catalonia, Spain; 6IQVIA, Reading, UK; 7Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA; 8Sanofi, Bridgewater, NJ, USA Purpose: Patient perspective is an important and increasingly sought-after complement to clinical assessment. The aim of this study was to transcribe individual patients’ experience of treatment in a dupilumab clinical trial through free-text responses with analysis using natural language processing (NLP) to obtain the unique perspective of patients on disease impact and unmet needs with existing treatment to inform future trial design. Patients and Methods: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) who were enrolled in a Phase IIa randomized controlled trial comparing dupilumab with placebo (NCT01920893) were invited to complete a self-assessment of treatment (SAT) tool at the end of treatment, asking, “What is your opinion on the treatment you had during the trial? What did you like or dislike about the treatment? ” Free-text responses were analyzed for the overall cohort and according to treatment assignment using natural language processing including sentiment scoring. In a mixed-methods approach, quantitative patient-reported outcome (PRO) results were utilized to complement the qualitative analysis of free-text responses. Results: Of 60 patients enrolled in the study, 43 (71.6%) completed the SAT and responses from 37 patients were analyzed (placebo, n = 16; dupilumab, n = 21). Word analyses showed that the most common words were “smell,” “improve,” “staff,” “great,” “time,” and “good. ” Across the whole cohort, “smell” was the most common symptom-related word. The words “smell” and “experience” were more likely to occur in patients treated with dupilumab. Patients treated with dupilumab also had more positive sentiment in their SAT responses than those who received placebo. The results from this qualitative analysis were reflected in quantitative PRO results. Conclusion: “Smell” was important to patients with CRSwNP, highlighting its importance as a patient-centric efficacy outcome measure in the context of clinical trials in CRSwNP. Trial Registration: ClinicalTrials.gov, NCT01920893. Registered 12 August 2013, https:// www.clinicaltrials. gov/ct2/show/NCT01920893.
Edinburgh Explorer Using Prosody to Classify Discourse Relations

This work aims to explore the correlation between the discourse structure of a spoken monologue and its prosody by predicting discourse relations from different prosodic attributes. For this purpose, a corpus of semi-spontaneous monologues in English has been automatically annotated according to the Rhetorical Structure Theory, which models coherence in text via rhetorical relations. From corresponding audio ﬁles, prosodic features such as pitch, intensity, and speech rate have been extracted from different contexts of a relation. Supervised classiﬁcation tasks using Support Vector Machines have been performed to ﬁnd relationships between prosodic features and rhetorical relations. Preliminary results show that intensity combined with other features extracted from intra- and intersegmental environments is the feature with the highest predictability for a discourse relation. The prediction of rhetorical relations from prosodic features and their combinations is straightforwardly applicable to several tasks such as speech understanding or gen-eration. Moreover, the knowledge of how rhetorical relations should be marked in terms of prosody will serve as a basis to improve speech synthesis applications and make voices sound more natural and expressive.
Salinity is an agent of divergent selection driving local adaptation of 25 Arabidopsis thaliana to coastal habitats

Understanding the molecular mechanism of adaptive evolution in plants provides insights into 59 the selective forces driving adaptation, and the genetic basis of adaptive traits with agricultural 60 value. The genomic resources available for Arabidopsis thaliana make it well suited to the rapid 61 molecular dissection of adaptive processes. While numerous potentially adaptive loci have been 62 identified in A. thaliana , the consequences of divergent selection and migration, both important 63 aspects of the process of local adaptation, for A. thaliana are not well understood. Here, we use 64 a multi-year field-based reciprocal transplant experiment to detect local populations of A. 65 thaliana , composed of multiple small stands of plants (demes), that are locally adapted to the 66 coast and adjacent inland habitats in north-eastern Spain. We identify fitness trade-offs between 67 plants from these different habitats when grown together in inland and coastal common gardens, 68 and also when grown under controlled conditions in soil excavated from coastal and inland 69 sites. Plants from the coastal habitat also outperform those from inland when grown under high 70 salinity, indicating local adaptation to soil salinity. Sodium can be toxic to plants, and we find 71 its concentration to be elevated in soil and plants sampled at the coast. We conclude that the 72 local adaptation we observe between adjacent coastal and inland populations is due to ongoing 73 divergent selection driven by the differential salinity between coastal and inland soils.
Immobilisation and leaching performance of lead-acid batteries smelting slag using natural and waste materials

The slag generated in the rotary furnaces is classified hazardous waste. In this regard, landfill disposal of lead smelting slag is not feasible since a few hundred tons are produced per year; leaching of heavy metals into ground water is of concern. The release of heavy metals into the environment has resulted in a number of environmental problems. The disposal of slag is becoming more expensive each year due to large land areas needed for its disposal. The best way to solve the disposal problem of waste materials is to decrease the quantity for disposal with utilization of waste materials in the industry. The toxicity of the waste is determined by leaching tests and depending on the characteristics of the waste the spent abrasive must be disposed of as solid or hazardous waste. The aim of this study is to investigate leaching characteristics of lead smelting slag according to leaching tests such as TCLP, and TS EN 12457-4 tests methods. In this study, mixed-level factorial design was applied to optimize process parameters for lead removal from lead smelting slag using natural (sepiolite, montmorillonite, illite and seashell) and waste material (red mud). The established model was then used as a predictor to achieve better understanding of the adsorption process and to obtain optimal settings of the experimental factors. The present study includes the safe disposal of lead smelting slag using natural and waste materials. Experimental results indicated that red mud and seashell can be used as environmentally friendly adsorbents that are capable of lead release from lead smelting slag.
An Empirical Study on the Internal Control and Equity Capital Cost of Listed Companies

— In recent years, China's capital and securities market has been fluctuated under the globalization process and so on. Based on such realistic conditions, the state adopted the macro regulation and control mode and put forward the concept of "new normal economy". The appliance industry has been expanding rapidly in recent years. Giant companies are seeking overseas expansion, such as the US, GREE, Haier and other enterprises. Small and medium-sized enterprises seek to go public, expand their scale through capital operation and seize market share. In the new normal background, this paper selects the appliance industry listed companies as the main target and lists company's internal control quality as a starting point, focusing on how the internal control effect and reduce the cost of equity capital through the empirical analysis. The conclusion of this paper shows that the internal control is negatively related to the cost of equity capital, and the correlation is not significant. This provides new ideas for the management and production organization of enterprises, and puts forward relevant policy recommendations, aiming at finding the existing problems and prospecting future research trends .
Learning Ostensive Knowledge of Shaft Parts based on CRF model

: During the process of mechanical design, there exit a large amount of knowledge and information that needs to be obtained by consulting and referencing past cases. This type of knowledge is called ostensive knowledge in philosophy, and belongs to a typical relational tacit knowledge. On the one hand, ostensive knowledge cannot be expressed through words, numbers, scientific formulas, and coding procedures. On the other hand, knowledge is parasitic in cases and cannot exist independently from them. This paper introduces ostensive knowledge to the mechanical design field for the first time, and points out that the learning model of ostensive knowledge must have the memories of cases and the ability of case-based reasoning. On this basis, this paper focuses on the shaft parts, and proposes an ostensive knowledge learning model for shaft parts based on the conditional random field model. Finally, an experiment is carried out using actual engineering cases to analyze and verify the model, which shows that the model has good memory and reasoning capabilities for shaft parts cases.
XLS Deliverable D3.1 Preliminary assessments and evaluations of the optimum e-gun and injector solution for the CompactLight design

Abstract In this deliverable we report an overview of the possible injector options suitable to match the CompactLight X-band high brightness linac able to drive short wavelength FELs user facilities. Different schemes have been investigated including RF gun injectors at different operating frequency (S, C and X band) and a DC gun based design. The electromagnetic and RF designs for all cases are reported and discussed, including a preliminary evaluation of the laser/cathode system requirements. Match-ings with the downstream linac are also investigated with beam dynamics simulations. State the look appropriate at rate ( On the other end a compact (or RF gun design expected have better at and due load, could allow higher rates DC guns are also very promising solutions
A SURVEY ON ACCURACY OF REQUIREMENT TRACEABILITY LINKS DURING SOFTWARE DEVELOPMENT

Traceability is used to ensure that source code of a system is consistent with its requirements. The only specified requirement has been implemented by developers. During software maintenance and evolution, requirement traceability links become marginal because no developer can devote effort to update it. However, to recover traceability links later is a very painful and monotonous task also it is costly for developers too. Traceability supports the software development process in various ways, like as change management, software maintenance and prevention of misunderstandings. But, while, in practice, traceability links between requirements and codes are not created during the development of software as it requires extra efforts. So developers rarely use such links during development. Why many challenges exist in traceability practices today? However, many of the challenges can be overcome through organizational policy, quality requirements traceability tool support remains the open problem.
High-Order , Robust Multidimensional Summation-by-Parts Discretizations Applicable to hp-adaptive Curvilinear Grids by Siavosh Shadpey

High-Order, Robust Multidimensional Summation-by-Parts Discretizations Applicable to hp-adaptive Curvilinear Grids Siavosh Shadpey Master of Applied Science Graduate Department of Institute for Aerospace Studies University of Toronto 2019 The focus of this thesis is on the development of high-order semi-discrete methods for the Euler equations that are applicable to non-conforming curvilinear grids arising from h-, p-, and hp-refinement. First, we present a method stable for linear differential equations. Second, we present two schemes stable for nonlinear differential equations. These two methods differ in the coupling procedure of neighbouring elements in a mesh: one couples them in a pointwise manner, while the other in a skew-symmetric manner. Finally, we present a fourth scheme which is numerically robust and discretely mimics the kinetic energy equation – an attractive property for simulating turbulent flows. The conservation, accuracy, and stability properties of the methods are first theoretically proven and then numerically verified. Furthermore, preliminary studies comparing all four methods in terms of robustness and computational efficiency are provided.
A Design for Self-Assembling Robots in a System

This thesis presents the design, construction, control, and application for a novel concept of self-assembling robots in a system. The system is composed of multiple cooperative robots that are designed to self-assemble in a system, execute manipulative tasks, and self-repair, all without human assistance. The self-assembling feature employs four mechanical design guidelines: independent module, one touch assembly design, selfalignment, and self-guiding. The independent design feature also employs independent motor control boards and a wireless communication board. For a decoupling effect, we chose a motor with large gear ratio. For safety and modularization purpose, we implemented a newly designed Series Elastic Actuator to limit shock bandwidth by using its compliance and sense forces during manipulative tasks. This thesis introduces a control algorithm, according to design parameters. With the results of dynamic simulations, we developed a preliminary algorithm for picking up a based on subsumption architecture. Finally, we verified the design and algorithm via an application, picking up a module in unstructured environments. Thesis Supervisor: Rodney Brooks Title: Panasonic Professor of Robotics Thesis Reader: John Leonard Title: Associate Professor of Mechanical and Ocean Engineering
A Virtual Navigation in a Reconstruction of the Town of Otranto in the Middle Ages for Playing and Education

— The aim of the MediaEvo Project is to develop a multi-sensory platform for the edutainment in Cultural Heritage towards integration of human sciences and new data processing technologies, for the realization of a digital didactic game oriented to the knowledge of medieval history and society. The developing of the project has enhanced interactions among historical, pedagogical and ICT researches, by means of the definition of a virtual immersive platform for playing and educating and has permitted to investigate some navigation and interaction modalities among players for education purposes. In this paper we present some results of the MediaEvo Project that has led the researchers to use the reconstruction of the city of Otranto in the Middle Ages in order to determine the conditions for testing more elements of interaction in a virtual environment and a multisensory mediation in which merge objects, subjects and experiential context. With the aim to make interaction easier for users without any experience of navigation in a virtual world and more efficient for trained users, we use the Wiimote and the Balance Board of Nintendo in order to increase the sense of immersion in the virtual environment.
Induced Velocities Near a Lifting Rotor with Nonuniform Disk Loading

A method is given for converting known uniformly loaded rotor induced velocities to correspond with arbitrary axisymmetric nonuniform disk load distributions. Numerical results for two specific distributions are given in chart form. Symmetry relations and relations between radial disk loading and wake velocities are developed. Experimental flow measurements are presented and compared with theory. Reasonable agreement is shown in the forward part of the flow when nonuniform loading is assumed, but far behind the rotor the flow is more like that of a wing.
Stellar Parameters of Wolf-Rayet Stars from Far-UV to Mid-IR Observations

Recent results for Galactic and Magellanic Cloud Wolf-Rayet stars are summarised based on line blanketed, clumped model atmospheres together with UV, optical and IR spectroscopy. The trend towards earlier WN and WC spectral types with decreasing metallicity is explained via the sensitivity of classification diagnostics to abundance/wind density, such that WR mass-loss rates are metallicity dependent. Pre-supernovae masses for WC stars are determined, in reasonable agreement with CO-cores of recent Type-Ic SN.