Miracle-dz/UniFAR-FTUs huggingface dataset:
Review on Stability and Power Quality Problem and Mitigation on Renewable Energy Penetration in Grid System

Abstract: An increase in the production and integration of renewable energy sources to the power grid system have begun to have an impact on the stability and security of the power grid. As renewable energy sources (RESs) like solar PV array plant and wind plant begin to displace traditional power plants, grid integration requirements have become an important issue. To ensure grid stability, additional criteria and technological constraints have been implemented. An updated assessment of current integration criteria and compliance control techniques for renewable power plant integration into the electric grid is being conducted as part of this study to close the knowledge gap. There is a comparison of the most important criterion for grid stability, including frequency stability and voltage stability, quality of power, voltage ride-through (VRT), reactive and active power controls. To meet these standards, a variety of control techniques have recently been proposed. As a result, cutting-edge options for compliance technologies and control techniques are analysed and evaluated in this paper. Additionally, a thorough examination of the benefits, challenges, and drawbacks of global harmonisation of integration requirements is included. Even though current incorporation necessities may enhance grid security, stability, operation, and dependability, a thorough assessment concludes that further improvements to shielding legislation, optimization of control system and international harmonisation are still required. There are a number of recommendations for further research into the integration and technical limitations of RESs that follow this. This study's findings could help to create a seamless and stable grid integration of RESs, as well as aid researchers in the development of new design methods and control systems based on current requirements. Educate and support operators in power system for creating or cultivating their individual standards that differ from the international norms that remain in place. Keywords: fault ride-through, Current limitation, grid forming control, grid connection, voltage-source converter
An Investigation of Issues Affecting the Role of Renewables in Future Australian Electricity Generation

While there are a variety of other sustainability issues, the most significant challenge for the Australian electricity generation market in the future is to meet rising demand for goods and services which depend on low cost energy and, at the same time, reduce greenhouse gas emissions. There are several different paths that may be pursued to reach this goal including more efficient use of electricity. From a generation point of view there are several technology options such as switching to low carbon fuel sources, increasing fuel to electricity conversion efficiency and carbon dioxide (Cod capture and storage. The uptake of these technologies depends on a variety of factors such as the policy framework provided by government, the pace of technological change and a variety of technical and social factors. This paper is primarily concerned with the uptake of renewable electricity generation. The sensitivity of uptake projections to alternative assumptions regarding electricity system constraints and the use of energy storage are explored and their implications presented.
Metformin Reverses tmexCD1-toprJ1- and tet(A)-Mediated High-Level Tigecycline Resistance in K. pneumoniae

Tigecycline (TIG) is one of the last effective options against multidrug resistance bacteria. Recently, the RND (resistance–nodulation–division) efflux pump gene cluster, tmexCD1-toprJ1, and the tetracycline-efflux pump tet(A) mutation were reported to mediate high level resistance to TIG in clinically important pathogens, weakening the efficacy of TIG. In this study, we report the potent synergistic effect of the antidiabetic drug metformin in combination with TIG against tet(A) mutant and tmexCD1-toprJ1 positive K. pneumoniae. The fractional inhibitory concentration index (FICI) of TIG and metformin were less than 0.05 for all the tested isolates. The time–kill curve assay showed that the combination of TIG and metformin exhibited much better antimicrobial effect than TIG alone. The synergistic effect was also confirmed in vivo using a well-studied Galleria mellonella larvae model. Mechanistic studies demonstrated that metformin disrupted the important component of proton motive force, the electric potential (Δψ) and the function of efflux pump, thereby increasing the intracellular concentration of TIG. This finding revealed that metformin might be a possible adjuvant of TIG for combating with superbugs carrying the tet(A) mutant and tmexCD1-toprJ1 genes.
Perceptions of interest and agency explain disagreements about sexual violations

Sexual violations have profound, negative impacts on victims. But although most people agree that sexual assault and other sexual violations are wrong, they often disagree about which acts constitute sexual violations. Moral psychological research suggests that evaluations about right and wrong actions are based on social perceptions, for instance about how actions affect others. Three studies examined whether perceptions about victims’ sexual interest and agency explain disagreements about ambiguous sexual violations (situations that lacked explicit and consistent consent or non-consent). The studies also examined whether such perceptions about sexual interest and agency in concrete situations related to general beliefs about sexual encounters, known as rape myths. Participants read hypothetical vignettes about potential sexual violations and reported their perceptions and evaluations of the events. Studies 1 and 2 found that, in response to ambiguous events, participants who perceived greater sexual interest and agency in the targets of sexual actions evaluated the actions more positively. The studies also found that, relative to ambiguous events, participants evaluated consensual events more positively and nonconsensual events less positively. As an experimental test of the effects of perceived target interest, Study 3 manipulated conventions for signaling sexual interest. The results provided experimental evidence that perceptions of sexual interest guide evaluations of potential sexual violations. Across the three studies, individual differences in two forms of Rape Myth Acceptance predicted perceptions of target interest and agency. This research provides evidence for how social perceptions shape evaluations of potentially ambiguous sexual events, thus validating a framework for explaining and preventing disagreements about sexual violations.
An endemic‐rich island through the eyes of children: Wildlife identification and conservation preferences in São Tomé (Gulf of Guinea)

Species that the public knows and is willing to protect often do not align with international conservation priorities. Assessing perceptions on wildlife is thus essential to guide conservation initiatives, especially in island developing states where native and introduced species often have contrasting values for biodiversity. We used a game to assess the ability of third class students in São Tomé Island (São Tomé and Príncipe, central Africa) to identify wildlife and their conservation preferences. Students correctly identified 28% of the animals shown. Children who were poorer, male or from rural schools were more likely to correctly identify species. Urban children were less successful identifying species endemic to São Tomé and Príncipe than rural children. Conservation preferences were not associated with species identification and instead were justified by subjective species‐specific traits, such as attractiveness or profitability. Despite the low identification rates for endemic (10% correct identifications) and threatened birds (2%), children were keen on preserving endemic species, indicating that these might become effective flagships for the unique biodiversity of the island. These results illustrate the need to consider separately the attributes that affect knowledge and willingness to protect, and how both can be used to guide conservation strategies.
ANTIBIOTIC SUSCEPTIBILITY OF ESCHERICHIA COLI WILD STRAINS

Escherichia coli is the normal microbe of the intestinal microflora but can cause different illnesses exception the intestinal tract. And the most problem of the illness with E. coli etiology is the rapid antibiotic resistance forming of the current pathogen. We had the aim to detect the antibiotic susceptibility of E. coli strains separated from the samples of the ill cattle in endometritis and mastitis. 12 types of antimicrobial preparations were tested. We have founded, wild E. coli strains were totally resistant to vancomycin, streptomycin, tetracycline, doxycycline, kanamycin, amoxicillin, and tylosin. Drugs of the cephalosporine range also were un-efficient. And just furazolidone, enrofloxacin, and gentamycin have shown the effective action to tested samples of E. coli. So, the testing of antibiotic susceptibility is the obligatory action in therapy-list formation. Just this action can demonstrate the efficient antimicrobial drugs that can provide the recovery of the illness animals.
Application of Process Power Spectrum Entropy in Rotor Vibration Quantitative Diagnosis

Aiming at the complexity of rotating machinery vibration process and the randomcity of vibration fault, a fault quantitative diagnosis method which described the change disciplinarian of rotor vibration by power spectrum information entropy(power spectrum entropy)difference matrix under more measurement points and multi-speed based on the information entropy theory was presented. Four typical failures of rotor vibration were simulated based on rotor experiment and vibration fault data under more points and multi-speed were collected, and then the power spectrum entropy matrix was calculated through analyzing and processing the data. The result show that the validity of the method between distinguishing the rotor fault types and determining the fault severity is proved to be effective by example calculation and analysis of rotor vibration fault signals.
Mesonephric-like Adenocarcinoma of the Ovary: Clinicopathological and Molecular Characteristics

Mesonephric-like adenocarcinoma (MLA) arising in the ovary is a rare malignant tumor of the female genital tract. Although the clinicopathological and molecular characteristics of uterine MLA have been accumulated, those of ovarian MLA have not been firmly clarified. In this study, we investigated the clinicopathological, immunohistochemical, and genetic features of five ovarian MLAs. A review of electronic medical records and pathology slides, immunostaining, and targeted sequencing was performed. On imaging, ovarian MLA presented as either a mixed solid and cystic mass or a purely solid mass. One, three, and one patient were diagnosed as having FIGO stage IA, IC, and II MLA, respectively. Four patients with stage IC–II tumor underwent post-operative adjuvant chemotherapy. Three of the four patients whose follow-up information was available did not experience recurrence. In contrast, the remaining patient with stage IA tumor who did not receive any adjuvant treatment developed multiple metastatic recurrences at post-operative 13 months. Histologically, ovarian MLAs characteristically displayed architectural diversity, compactly aggregated small tubules, and eosinophilic intraluminal secretions. Four tumors were found to be associated with endometriotic cysts. Two cases showed some areas of high-grade nuclear atypia, brisk mitotic activity, and necrosis. Immunohistochemically, all cases showed positive immunoreactivities for at least three of the four examined mesonephric markers (GATA3, PAX2, TTF1, and CD10), lack of WT1 expression, non-diffuse p16 immunoreactivity, and wild-type p53 immunostaining pattern. Targeted sequencing analysis revealed that all four examined cases harbored pathogenic KRAS mutations: p.G12V (2/4); p.G12D (1/4); and p.G12C (1/4). In addition, we reviewed the previous literature reporting 60 cases of ovarian MLA. Our findings corroborate those of the previous data regarding the clinical presentation, histological features, immunophenotypes, and molecular alterations. Our observations should encourage pathologists to recognize and accurately diagnose this rare but distinct entity.
Ultraviolet dosage and decontamination efficacy were widely variable across 14 UV devices after testing a dried enveloped ribonucleic acid virus surrogate for SARS-CoV-2

Aims The dosages and efficacy of 14 ultraviolet (UV) decontamination technologies were measured against a SARS-CoV-2 surrogate virus that was dried on to different materials for lab and field testing. Methods and Results A live enveloped, ribonucleic acid (RNA) virus surrogate for SARS- CoV-2 was dried on stainless steel 304 (SS304), Navy Top Coat-painted SS304 (NTC), cardboard, polyurethane, polymethyl methacrylate (PMMA), and acrylonitrile butadiene styrene (ABS) at > 8.0 log10 plaque-forming units (PFU) per test coupon. The coupons were then exposed to UV radiation during both lab and field testing. Commercial and prototype UV- emitting devices were measured for efficacy: 4 handheld devices, 3 room/surface-disinfecting machines, 5 air-disinfection devices, and 2 larger custom-made machines. UV device dosages ranged from 0.01-729 mJ cm-2. Anti-viral efficacy among the different UV devices ranged from no decontamination up to nearly achieving sterilization. Importantly, cardboard required far more dosage than SS304. Conclusions Enormous variability in dosage and efficacy was measured among the different UV devices. Porous materials limit the utility of UV decontamination. Significance and Impact of the Study UV devices have wide variability in dosages, efficacy, hazards, and UV output over time indicating that each UV device needs independent technical measurement and assessment for product development, prior to, and during use.
Study on Crashworthiness of Honeycomb Sandwich Panel under Lateral Dynamic Load

The HSP(honeycomb sandwich panel) can provide an excellent mechanical performance of high ratio of strength to weight.Consequently,the HSP is widely used in the lightweight transportation system such as the aircraft,the high-speed train and the fast ship.The aim of present study is to investigate the crashworthiness of the HSP under lateral dynamic load through the simulation with the finite element program MSC/Dytran.The deformation,the crushing load,the energy absorption as well as the crashworthiness index are studied through a series of numerical simulations.The comparison between the HSP and the equivalent flat plate is carried out.The relation between the structural dimension and the crashworthiness of the HSP is concluded.Results from numerous numerical simulations show that the HSP can provide an excellent crashworthiness.The density is critical variable affecting the crashworthiness.The core height is not the critical influential parameter,and the energy absorption increases with the increasing of the core height.
Furry Families: Ethical Entanglements Through More-than-Human Domestic Dramas

Companion animals (CA) are seen as part of the family by their human guardians. However, guardians’ intense attitudes towards CA can lead to tensions with larger society. Recent scholarship has argued for more critical work exploring interspecies family relations. The present research is framed by previous scholarship exploring CA family relations and the role that storytelling about animals plays in developing ethical relations with animals. We examine 369 stories told by guardians of companion animals as part of a One Welfare study examining attitudes to companion animal welfare. Our analytical frame was a genre discourse approach sensitive to questions of animal ethics. Our theoretical contribution is to contribute a new sub-genre of domestic drama, more-than-human domestic drama. We explore the implications of this genre of family stories and why it matters beyond families to wider society.
The role of long non-coding RNA LINC01296 in oral squamous cell carcinoma: a study based on bioinformatics analysis and in vitro validation

Background: Oral squamous cell carcinoma (OSCC) is a common malignancy in the oral cavity that represents a significant global health problem. Multivariate analysis has shown that long non-coding RNA LINC01296 plays an important role in cancer biology. However, the functions of LINC01296 in OSCC are still unknown. Methods: The RNA profiles and clinicopathological information of OSCC patients and healthy subjects were downloaded. The expression level and prognostic value of LINC01296 were assessed. The functions and pathways of LINC01296were explored using the Gene Set Enrichment Analysis (GSEA) and functional analysis. The expression of LINC01296 in OSCC tissues and cell lines was determined by RT-qPCR. MTS assay was used to evaluate cell growth. The migration and invasion capacities of cells were assessed by wound healing assay and Transwell assay. Results: LINC01296 was overexpressed in the TCGA-OSCC datasets. High LINC01296expression was strongly correlated with poor outcomes of OSCC patients. LINC01296 was overexpressed in OSCC tissues compared with para-carcinoma tissues. Moreover, the expression of linc01296 was higher in CAL-27, HSC-2, and SCC-25 cells than in normal human oral keratinocytes (NHOKs). Functional analysis suggested that LINC01296might be involved in the regulation of the Wnt and MAPK signaling pathways. Additionally, LINC01296 deficiency suppressed the growth, migration, and invasion of OSCC cells, whereas overexpression of TFAP2A-AS1 cause opposite results. Conclusion: Our study showed that LINC01296 promoted OSCC cell growth, migration, and invasion, suggesting that LINC01296 might be a potential therapeutic target for OSCC.
In silico Evaluation of Selected Compounds from Bergenia ciliata (Haw.) Sternb against Molecular Targets of Breast Cancer

Background: A daunting public health issue that mainly affects women is breast cancer. Resistance to drugs applied in the treatment of this cancer as well as their side effects have made it necessary to look for new therapeutic agents. Objectives: The study is aimed at identification of multi-targeted inhibitors of molecular targets associated with breast cancer. Methods: We investigated fifteen compounds from Bergenia ciliata (haw.) Sternb against four major molecular targets of breast cancer viz; estrogen receptor-α (ER-α), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2/ ERBB2) and epidermal growth factor receptor (EGFR) by docking simulation. Properties describing ADME/T aspects of the potential compounds were also investigated by in silico approach. Results: Among the fifteen compounds investigated, stigmasterol, β-sitosterol, paashaanolactone and afzelechin exhibited more or comparable binding affinity values with the different targets compared to that of native ligands and therefore may be developed as leads for multi-targeted therapy against breast cancer. Conclusion: Considering the molecular docking results and ADME/T analysis, it can be suggested that these compounds can be subjected to further structural modification and in vivo analysis for evaluating the potential of their candidacy as new drugs in the field of treatment and management of breast cancer.
Tailored PRISMA 2020 flow diagrams for living systematic reviews: a methodological survey and a proposal

Background: While the PRISMA flow diagram is widely used for reporting standard systematic reviews (SRs), it was not designed for capturing the results of continual searches for studies in living systematic reviews (LSRs). The objectives of this study are (1) to assess how published LSRs report on the flow of studies through the different phases of the review for the different updates; (2) to propose an approach to reporting on that flow. Methods: For objective 1, we identified all LSRs published up to April 2021. We abstracted information regarding their general characteristics and how they reported on search results. For objective 2, we based our proposal for tailored PRISMA approaches on the findings from objective 1, as well as on our experience with conducting Cochrane LSRs. Results: We identified 279 living publications relating to 76 LSRs. Of the 279 publications, 11% were protocols, 23% were base versions (i.e., the first version), 50% were partial updates (i.e., does not include all typical sections of an SR), and 16% were full updates (i.e., includes all typical sections of an SR). We identified six ways to reporting the study flow: base separately, each update separately (38%); numbers not reported (32%); latest update separately, all previous versions combined (20%); base separately, all updates combined (7%); latest update version only (3%); all versions combined (0%). We propose recording in detail the results of the searches to keep track of all identified records. For structuring the flow diagram, we propose using one of four approaches. Conclusion: We identified six ways for reporting the study flow through the different phases of the review for the different update versions. We propose to document in detail the study flow for the different search updates and select one of our four tailored PRISMA diagram approaches to present that study flow.
Cancer-on-a-Chip: Models for Studying Metastasis

Simple Summary Microfluidic-based cancer-on-a-chip models are powerful tools to study the tumor microenvironment (TME). Two-dimensional cell culture cannot recapitulate TME. In vivo animal models can better represent the TME, but their physiology is vastly different from that of humans. Although three-dimensional tumor models can bridge the gap between in vitro and in vivo examination, they are still unable to test many crucial cues from the TME, such as mechanical cues, cell–cell, and cell–extracellular interactions. Cancer-on-a-chip platforms enable studying the metastatic process in a step-wise manner with precise control. We present an overview of the recent advances in cancer-on-a-chip models on metastasis including models that mimic mechanical cues. This review article will provide knowledge of the latest progress made on cancer-on-a-chip models. Abstract The microfluidic-based cancer-on-a-chip models work as a powerful tool to study the tumor microenvironment and its role in metastasis. The models recapitulate and systematically simplify the in vitro tumor microenvironment. This enables the study of a metastatic process in unprecedented detail. This review examines the development of cancer-on-a-chip microfluidic platforms at the invasion/intravasation, extravasation, and angiogenesis steps over the last three years. The on-chip modeling of mechanical cues involved in the metastasis cascade are also discussed. Finally, the popular design of microfluidic chip models for each step are discussed along with the challenges and perspectives of cancer-on-a-chip models.