Miracle-dz/UniFAR-FTUs huggingface dataset:
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2Many examples of microfluidic systems have been studied in various fields. Normally, micropumps in microfluidic systems are powered by electricity or heat generated from electric energy and the actuation is controlled by on±off switching of external inputs. Herein we report a novel autonomous flow control inside microfluidic channels powered by self-oscillating gels without external control devices. Self-oscillating gels exhibit a volume oscillation driven by the oscillatory Belousov±Zhabotinsky (BZ) reaction. Our approach greatly simplifies the microfluidic system construction because there is no need for the electric wiring and source. In this paper, we first demonstrate a directional fluid pumping within microfluidic channels and a directional flow rate was 0.02 μL/min utilizing self-oscillating gels. This self-actuated pump could serve as a new framework for microfluidic devices.
1 Baseline mapping of Schistosomiasis and Soil 2 Transmitted Helminthiasis in the Northern and 3 Eastern health regions of Gabon , Central Africa : 4 Recommendations for preventive chemotherapy 5

In order to follow the Preventive Chemotherapy for the transmission control as 25 recommended by WHO, Gabon initiated in 2014 the mapping of Schistosomiasis and Soil 26 Transmitted Helminthiasis (STH). Here we report the results of the Northern and Eastern health 27 regions, representing a third of the land area and 12% of its total population. All the 9 departments 28 of the two regions were surveyed and from each, 5 schools were examined with 50 schoolchildren 29 per school. The parasitological examinations were realized using the filtration method for urine and 30 the Kato-Katz technique for stool samples. Overall 2245 schoolchildren (1116 girls and 1129 boys), 31 mean aged 11.28 ± 0.04 years, were examined. Combined schistosomiasis and STH affected 1270 32 (56.6%) with variation between regions, departments and schools. For schistosomiasis, prevalence 33 were 1.7% across the two regions, with no significant difference (p>0.05) between the Northern (1.5%) 34 and the Eastern (1.9%). Schistosomiasis is mainly caused by Schistosoma haematobium with a 35 prevalence of 1.5%, 1.9% and 1.7%, respectively in the North, East and globally. STH are more 36 common than schistosomiasis, with an overall prevalence of 56.1% significantly different between 37 the Northern (58.1%) and Eastern (53.6%) regions (p=0.034). Trichuris trichiura is the most abundant 38 infection with a prevalence of 43.7% followed by Ascaris lumbricoides 35.6% and hookworms 1.4%. 39 According to these results, an appropriate mass drug administration strategy is given for the control 40 of each neglected tropical disease group surveyed. 41
An Information Diffusion Approach for Detecting Emotional Contagion in Online Social Networks

Internet sites that support user-generated content, so-called Web 2.0, have become part of the fabric of everyday life in technologically advanced nations. Users collectively spend billions of hours consuming and creating content on social networking sites, weblogs (blogs), and various other types of sites in the United States and around the world. Given the fundamentally emotional nature of humans and the amount of emotional content that appears in Web 2.0 content, it is important to understand how such websites can affect the emotions of users. This work attempts to determine whether emotion spreads through an online social network (OSN). To this end, a method is devised that employs a model based on a general threshold diffusion model as a classifier to predict the propagation of emotion between users and their friends in an OSN by way of mood-labeled blog entries. The model generalizes existing information diffusion models in that the state machine representation of a node is generalized from being binary to having n-states in order to support n class labels necessary to model emotional contagion. In the absence of ground truth, the prediction accuracy of the model is benchmarked with a baseline method that predicts the majority label of a user’s emotion label distribution. The model significantly outperforms the baseline method in terms of prediction accuracy. The experimental results make a strong case for the existence of emotional contagion in OSNs in spite of possible alternative arguments such confounding influence and homophily, since these alternatives are likely to have negligible effect in a large dataset or simply do not apply to the domain of human emotions. A hybrid manual/automated method to map mood-labeled blog entries to a set of emotion labels is also presented, which enables the application of the model to a large set (approximately 900K) of blog entries from LiveJournal.
Upregulation of p 38 pathway accelerates proliferation and migration of MDA-MB-231 breast cancer cells

Tumor cells capture the signaling pathways used by normal tissue to promote their own survival and dissemination and among them, the NF-κB and MAPK pathways (ERK, JNK and p38). MAPK activation has ambiguous effects on tumor cell fate depending on cell type, cancer stage and the engaged MAPK isoforms. A synthetic peptide named LyeTx II, derived from the venom of the Brazilian spider Lycosa erythrognatha, was capable of increasing MDA-MB231 aggressive breast cancer cell proliferation as indicated by MTT and BrdU (5-bromo-2'-deoxyuridine) incorporation assay and cell migration. A correlation has been established between the accelerated proliferation and migration observed in the presence of LyeTx II and the upregulation of p38 MAPK phosphorylation. The use of the selective inhibitor of p38α/β (SB203580) abrogated the peptide effect in MDA-MB-231 cells. Besides, an augment of the canonical NF-κB pathway activation considered as crucial in cancer progression was noted after cell incubation with LyeTx II. Importantly, activation of p38 and NF-κB pathways was dependent on TAK1 activity. Together, these data suggest that TAK1-p38 pathway may represent an interesting target for treatment of aggressive
A novel VR-based simulator for the interventional surgical catheter and guidewire cooperation

Minimally invasive surgery (MIS) is an emerging technique, which is widely used and studied for computer-assisted training. The cooperation of the catheter and the guidewire is an essential part during the MIS procedure, which is not fully paid attention to but anatomic vascular deformation simulation. In this paper, a novel simulator integrated with a complete strategy for the cooperation of the catheter and the guidewire is proposed. A composite model of the physically based catheter and the guidewire, which are mapped to distinguished visual model and collision model of these two devices, is constructed at the initial point in the aorta vessels. Once it comes into the neurovascular cavity, the composite model is decomposed to two physically based model corresponding to the catheter and the guidewire respectively. Thereafter, the guidewire is operated and propelled through the catheter, which is fixed in position. The results show that the composite model exhibits equivalent efficiency and effectiveness as well as the separate catheter model, especially at the bifurcation of the vessels. The simulator proposed herein provides a fundamental module meeting the real-time and realistic requirements of our endovascular interventional surgery training system.
Sensing human hand motions for controlling dexterous robots

The Dexterous Hand Master (DHM) system is designed to control dexterous robot hands such as the UTAH/MIT and Stanford/JPL hands. It is the first commercially available device which makes it possible to accurately and confortably track the complex motion of the human finger joints. The DHM is adaptable to a wide variety of human hand sizes and shapes, throughout their full range of motion.
Line Managers’ HR Implementation Level and Work Performance: Estimating the Mediating Role of Employee Outcomes

The ongoing debate to unlock the black box between HRM and performance is yet to be fully concluded. This paper addresses the recent calls by adding three employee outcomes (affective commitment, job satisfaction, and turnover intention) as a mediating mechanism in the causal chain from HR implementation level - i.e., the extent of organization's HR practices that are implemented by each line manager - to work performance. Primary data was collected through a self-administrative survey from 200 permanent employees and 82 supervisors/line managers working in four manufacturing firms. The data was analyzed using SPSS process macros and AMOS. The results reveal that line managers HR implementation level increases work unit performance. Furthermore, an elevated level of HR implementation enhances employees’ affective commitment and job satisfaction and reduces their turnover intention and mediating role of these employee outcomes is fully supported by our data. The paper advances the strategic HRM research and contributes by providing a new mechanism to unravel the complexity of HRM-performance linkage debate.
D YNAMIC TARGETS IN THE ACQUISITION OF L 2 E NGLISH VOWELS

This paper presents acoustic data on the dynamic properties of the FLEECE and TRAP vowels in the speech of two groups of Polish users of English. Results reveal that the more proficient group users, made up of teachers and professors with professional-level proficiency in English, produce more dramatic patterns of formant movement, reminiscent of native productions, than first year students. It is argued that vowel inherent spectral change (VISC) is an inherent aspect of English phonology, originated in interactions between vowels and neighboring consonants, and later generalized to the vowel system as a whole. By contrast, Polish is a language with a minimal role of VISC. Consequently, successful acquisition of L2 English vowels involves not only the mastery of vowels in F1F2 space, but also formant trajectories over time.
65 COMPUTATIONAL TOPOLOGY FOR STRUCTURAL MOLECULAR BIOLOGY

The advent of high-throughput technologies and the concurrent advances in information sciences have led to a data revolution in biology. This revolution is most significant in molecular biology, with an increase in the number and scale of the “omics” projects over the last decade. Genomics projects, for example, have produced impressive advances in our knowledge of the information concealed into genomes, from the many genes that encode for the proteins that are responsible for most if not all cellular functions, to the noncoding regions that are now known to provide regulatory functions. Proteomics initiatives help to decipher the role of post-translation modifications on the protein structures and provide maps of protein-protein interactions, while functional genomics is the field that attempts to make use of the data produced by these projects to understand protein functions. The biggest challenge today is to assimilate the wealth of information provided by these initiatives into a conceptual framework that will help us decipher life. For example, the current views of the relationship between protein structure and function remain fragmented. We know of their sequences, more and more about their structures, we have information on their biological activities, but we have difficulties connecting this dotted line into an informed whole. We lack the experimental and computational tools for directly studying protein structure, function, and dynamics at the molecular and supra-molecular levels. In this chapter, we review some of the current developments in building the computational tools that are needed, focusing on the role that geometry and topology play in these efforts. One of our goals is to raise the general awareness about the importance of geometric methods in elucidating the mysterious foundations of our very existence. Another goal is the broadening of what we consider a geometric algorithm. There is plenty of valuable no-man’s-land between combinatorial and numerical algorithms, and it seems opportune to explore this land with a computational-geometric frame of mind.
Continual Learning and Catastrophic Forgetting

This book chapter delves into the dynamics of continual learning, which is the process of incrementally learning from a non-stationary stream of data. Although continual learning is a natural skill for the human brain, it is very challenging for artificial neural networks. An important reason is that, when learning something new, these networks tend to quickly and drastically forget what they had learned before, a phenomenon known as catastrophic forgetting. Especially in the last decade, continual learning has become an extensively studied topic in deep learning. This book chapter reviews the insights that this field has generated.
Title : The structural basis of the enhanced pollutant-degrading capabilities of an engineered 1 biphenyl dioxygenase 2 Running Title : Structural Studies of BphAE variant II 9 3

20 Biphenyl dioxygenase, the first enzyme of the biphenyl catabolic pathway, is a major determinant of 21 which PCB congeners are metabolized by a given bacterial strain. Ongoing efforts aim to engineer 22 BphAE, the oxygenase component of the enzyme, to efficiently transform a wider range of congeners. 23 BphAEII9, a variant of BphAELB400 in which a seven-residue segment, TFNNIRI, has been 24 replaced by the corresponding segment of BphAEB356, GINTIRT, transforms a broader range of 25 PCB congeners than either BphAELB400 or BphAEB356, including 2,6-dichlorobiphenyl, 3,3’26 dichlorobiphenyl, 4,4’-dichlorobiphenyl, and 2,3,4’-trichlorobiphenyl. To understand the structural 27 basis of the enhanced activity of BphAEII9, we have determined the three-dimensional structure of this 28 variant in substrate-free and biphenyl-bound forms. Structural comparison with BphAELB400 reveals a 29 flexible active site mouth and a relaxed substrate binding pocket in BphAEII9 that allow it to bind 30 different congeners, and which could be responsible for the enzyme’s altered specificity. Biochemical 31 experiments revealed that BphAEII9 transformed 2,3,4’-trichlorobiphenyl and 2,2’,5,5’32 tetrachlorobiphenyl more efficiently than BphAELB400 and BphAEB356 did. BphAEII9 also transformed 33 the insecticide DDT more efficiently than either parental enzyme (apparent kcat/Km = 2.2 ± 0.5 vs. 0.9 ± 34 0.5 mMs for BphAEB356). Docking studies of the enzymes with these three substrates provide insight 35 into the structural basis of the different substrate selectivity and regiospecificity of the enzymes. 36
Are Anticoagulants required after High Tibial Osteotomy to Prevent Venous Thromboembolism Events? A Systematic Review

Introduction High Tibial Osteotomy (HTO) is an operation that, although well-established, may be associated with complications including venous thromboembolism events. There is no consensus regarding postoperative thromboprophylaxis, including the routine use of anticoagulants. This review investigated two questions: (1) what are the incidence rates of venous thromboembolism events after HTO, and (2) what is the routine use of anticoagulants required in standard-risk patients? Methods We conducted a systematic review of PubMed and Cochrane databases from 1999 through 2014 using search terms high tibial osteotomy, HTO complications, HTO DVT, opening wedge osteotomy and closing wedge osteotomy. One-hundred and seven studies were included (opening-wedge osteotomy 3923 knees and closing-wedge osteotomy 3172 knees). Results The overall incidence rates of deep venous thrombosis and pulmonary embolism were 1.24% and 0.11%, respectively. Anticoagulants were used in 1,110 patients and aspirin was used in 312 patients. The relative risk of DVT was higher in patients that used anticoagulants compared with patients that did not use any form of chemoprophylaxis (1.99% and 1.11%, respectively; P = 0.02). The risk of DVT was higher in closing-wedge osteotomies compared with opening-wedge osteotomies regardless of the use of anticoagulants. Conclusion The incidence of venous thromboembolism events was very low after HTO, regardless of the use of chemoprophylaxis. Therefore, the necessity for anticoagulation after HTO in patients who do not have significant risk factors is questioned considering the side effects that may occur with these agents. Frank R Noyes1, Sue D Barber-Westin1*, and Martin S Levy2 1Cincinnati Sports medicine and Orthopaedic Center, Noyes Knee Institute, The Jewish Hospital-Mercy Health, Cincinnati, Ohio, USA 2Operations and Business Analytics and Information Systems, Lindner College of Business, University of Cincinnati, Cincinnati, Ohio, USA Are Anticoagulants required after High Tibial Osteotomy to Prevent Venous Thromboembolism Events? A Systematic Review
Winter 2015 Final Project Report Who Did It ? “ Investigating ” Detective Fiction Characters

We present a preliminary study of an intriguing problem: predicting a character’s guiltiness in Agatha Christie’s detective stories. Our main goal was to design character representations to be used as features to a guilty/innocent classifier. We experimented with elementary features such as number of mentions and typed dependencies, as well as continuous-space features derived from latent semantic analysis (LSA) and the very recent vector space word embeddings techniques used in word2vec and GloVe. Our results, while beating an easy baseline in most cases, indicate much more research is needed to make meaningful conclusions.
THREE-DIMENSIONAL MAGNETIC RESTRUCTURING IN TWO HOMOLOGOUS SOLAR FLARES IN THE SEISMICALLY ACTIVE NOAA AR 11283

We carry out a comprehensive investigation comparing the three-dimensional magnetic field restructuring, flare energy release, and the helioseismic response of two homologous flares, the 2011 September 6 X2.1 (FL1) and September 7 X1.8 (FL2) flares in NOAA AR 11283. In our analysis, (1) a twisted flux rope (FR) collapses onto the surface at a speed of 1.5 km s−1 after a partial eruption in FL1. The FR then gradually grows to reach a higher altitude and collapses again at 3 km s−1 after a fuller eruption in FL2. Also, FL2 shows a larger decrease of the flux-weighted centroid separation of opposite magnetic polarities and a greater change of the horizontal field on the surface. These imply a more violent coronal implosion with corresponding more intense surface signatures in FL2. (2) The FR is inclined northward and together with the ambient fields, it undergoes a southward turning after both events. This agrees with the asymmetric decay of the penumbra observed in the peripheral regions. (3) The amounts of free magnetic energy and nonthermal electron energy released during FL1 are comparable to those of FL2 within the uncertainties of the measurements. (4) No sunquake was detected in FL1; in contrast, FL2 produced two seismic emission sources S1 and S2 both lying in the penumbral regions. Interestingly, S1 and S2 are connected by magnetic loops, and the stronger source S2 has a weaker vertical magnetic field. We discuss these results in relation to the implosion process in the low corona and the sunquake generation.
Neural, cognitive, and neuroimaging markers of the suicidal brain

: Suicidal behavior (SB) is characterized by the occurrence of suicide attempts with substantial intent to die. SB is a major health problem worldwide. In the great majority of cases, SB occurs in patients suffering from psychiatric disorders, mainly from affective disorders or schizophrenia. Despite this high association, there is growing evidence from genetic studies that SB might represent a psychiatric condition on its own. This review provides an overview of the most significant neurobiological and neurocognitive findings in SB. We provide evidence for specific dysfunctions within the serotonergic system, for distinct morphological abnormalities in the gray and white matter composition as well as for neurofunctional alterations in the fronto-striatal network. Additionally, the putative role of impulsivity and hopelessness as trait-like risk factors for SB is outlined. Both the personality traits are associated with altered prefrontal cortex function and deficits in cognitive and affective control similar to the findings in SB. Given the difficulties of clinical risk assessment, there is a need to identify specific markers that can predict SB more reliably. Some recent neurocognitive and functional/structural neuroimaging findings might be appropriate to use as SB indicators in the close future.
Comparison of accuracy of digital and conventional radiographies in determining endodontic working length : research

Introduction : Determination of the length of the root canal is a critical step in endodontic therapy. Recently, digital radiography has been introduced for this purpose because it may have advantages over conventional radiographic methods. This study aimed to compare the accuracy of digital and conventional radiographic techniques in the determination of the endodontic working length (WL) Materials and methods : Sixty single-rooted premolar human teeth were selected for this study. The teeth were randomly divided into two groups. The WL determination in groups 1 and 2 was carried out using, respectively, digital and conventional radiographic techniques. The procedure was performed by a single operator on two separate occasions, two weeks apart. Results : The differences in WL measured at the two intra observer intervals was statistically significant neither in digital nor in conventional radiography method (P>0.05). The analysis of the data using a X2 test revealed that there were no significant differences in WL measurements between digital and conventional radiographic methods at any interval (P>0.05). Conclusion : Based on the findings of this study, it may be assumed that the digital and conventional radiographic techniques have similar accuracies in the determination of WL.
Sample Size, Precision and Power Calculations: A Uniï¬ed Approach

The sample size formulae given in elementary biostatistics textbooks deal only with simple situations: estimation of one, or a comparison of at most two, mean(s) or proportion(s). While many specialized textbooks give sample formulae/tables for analyses involving odds and rate ratios, few deal explicitly with statistical considerations for slopes (regression coefficients), for analyses involving confounding variables or with the fact that most analyses rely on some type of generalized linear model. Thus, the investigator is typically forced to use â€œblack-boxâ€? computer programs or tables, or to borrow from tables in the social sciences, where the emphasis is on correlation coefficients. The concern in the â€“ usually very separate â€“ modules or standalone software programs is more with user friendly input and output. The emphasis on numerical exactness is particularly unfortunate, given the rough, prospective, and thus uncertain, nature of the exercise, and that different textbooks and software may give different sample sizes for the same design. In addition, some programs focus on required numbers per group, others on an overall number. We present users with a single universal (though sometimes approximate) formula that explicitly isolates the impacts of the various factors one from another, and gives some insight into the determinants for each factor. Equally important, it shows how seemingly very different types of analyses, from the elementary to the complex, can be accommodated within a common framework by viewing them as special cases of the generalized linear model.