Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of Endothelial Cells in a Novel Mechanism of Tumor‐Induced Immune Suppression

Previous studies by our lab have shown that Lewis lung carcinoma (LLC)‐secreted products skew endothelial cells to suppress T cell, NK cell and macrophage functions. LLC‐derived VEGF has been identified as inducing endothelial cells to suppress T‐cell functions. In our current studies, we examined the role of endothelial cells in mediating suppression in human head and neck squamous cell carcinoma (HNSCC) and in the in vivo LLC tumor model. Antibody neutralization of HNSCC‐derived VEGF blocked tumor induced increases in endothelial cells production of VEGF and PGE2. T cells treated with HNSCC‐exposed endothelial cell conditioned media had decreased IFN‐γ production, compared to control treated T cells. Treatment of HNSCC‐conditioned media with VEGF neutralizing antibody prevented induction of suppressive endothelial cells toward T cell functions. We also examined the ability of tumors to induce suppressive endothelial cells in vivo. Conditioned media from endothelial cells isolated from the lungs of tumor‐bearing mice suppressed IFN‐γ production by CD8+T cells and IL‐2 by CD4+ T cells as compared to normal lung controls. Studies are ongoing to determine the role of VEGF in the induction of suppressive endothelial cells in vivo. Together these studies implicate induction of suppressive endothelial cells as a novel mechanism of tumor‐induced immune suppression. Supported by Dept of Veterans Affairs & NIH
OP-PCPJ140189 1..8

Interspecies Gene Expression Networks with NLP-Based Curation Hajime Ohyanagi, Tomoyuki Takano, Shin Terashima, Masaaki Kobayashi, Maasa Kanno, Kyoko Morimoto, Hiromi Kanegae, Yohei Sasaki, Misa Saito, Satomi Asano, Soichi Ozaki, Toru Kudo, Koji Yokoyama, Koichiro Aya, Keita Suwabe, Go Suzuki, Koh Aoki, Yasutaka Kubo, Masao Watanabe, Makoto Matsuoka and Kentaro Yano* School of Agriculture, Meiji University, Kawasaki, 214-8571 Japan CREST, JST, Saitama, 332-0012 Japan Tsukuba Division, Mitsubishi Space Software Co., Ltd., Tsukuba, 305-0032 Japan Plant Genetics Laboratory, National Institute of Genetics, Mishima, 411-8540 Japan Bioscience and Biotechnology Center, Nagoya University, Nagoya, 464-8601 Japan Graduate School of Bioresources, Mie University, Tsu, 514-8507 Japan Division of Natural Science, Osaka Kyoiku University, Kashiwara, 582-8582 Japan Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, 599-8531 Japan Graduate School of Environmental and Life Science, Okayama University, Okayama, 700-8530 Japan Graduate School of Life Sciences, Tohoku University, Sendai, 980-8577 Japan These authors contributed equally to this work. *Corresponding author: E-mail, kyano@isc.meiji. ac.jp; Fax, +81-44-934-7046. (Received August 29, 2014; Accepted November 24, 2014)
Regulation of Capillary Hemodynamics by KATP Channels in Resting Skeletal Muscle

ATP‐sensitive potassium (KATP) channels have been implicated in the regulation of resting vascular smooth muscle membrane potential and tone. However, whether KATP channels modulate skeletal muscle microvascular hemodynamics at the capillary level (the primary site for blood‐myocyte O2 flux) is unknown. We tested the hypothesis that KATP channel inhibition would reduce the proportion of capillaries supporting continuous red blood cell flow and impair microvascular hemodynamics in perfused capillaries in resting skeletal muscle.
Dark-field study of rear-side density structure in laser-accelerated foils. Memorandum report

A dark-field, laser-probing diagnostic has produced the first high-resolution photographs of density structure on the rear side of laser-accelerated foils. This diagnostic allows the preferential sampling of the steep-gradient region of an expanding plasma and permits two-dimensional, multiple-time recordings on a single photograph. The studies are aimed at understanding the early-time physics of target implosions for inertial-confinement fusion. Both long (500 psec) and short (150 psec) probe pulses were used to study the rear-side plasmas of thin foils accelerated by the rocket-like reaction to a hot plasma ablated from the front side by the laser radiation. The longer pulse results, both for angular scatter and the life-time of small, transverse structure, imply a relatively cold (1 eV) rear side plasma. The short pulses provide high resolution photographs of the complete structure. One of these was a vortex-like structure, suggestive of the remnants of a hydrodynamic instability. These observations are relevant to two of the basic requirements of inertial-confinement fusion: cold fuel isentrope and implosion symmetry.
Reconstruction of network structures from core patterns

Core patterns from a neuronal network have been proposed to be useful in the reconstruction of the network topology. Reverberations in a physiologically realistic model with various physical connection topologies (from random to scale-free) have been simulated to study the effectiveness of the core-pattern method in the reconstruction of network topology from network dynamics. Simulation results show that functional networks reconstructed from core patterns can be quite different from the original physical networks; even global properties, such as the degree distribution, cannot always be recovered. However, the core-pattern method can be effective in identifying hubs in the network. Since the form of reverberations are quite different for networks with and without hubs, the form of reverberations together with the reconstruction by core patterns might provide a reliable method to detect hubs in neuronal cultures.
The Position of the Finite Verb in Swedish

A process is provided to form spherical thermoplastic particles that involves dispersing a thermoplastic powder in a liquid that is a partial solvent for the thermoplastic, breaking the dispersion into droplets, forming thermoplastic spheres by heating the droplets to a temperature sufficient to at least partially solubilize the thermoplastic and to evaporate the solvent. Unique products, including porous structures, may be produced from material formed by this process.
Approximation Algorithms for Clique Clustering

A clique clustering of a graph is a partitioning of its vertices into disjoint cliques. The quality of a clique clustering is measured by the total number of edges in its cliques. We consider the online variant of the clique clustering problem, where the vertices of the input graph arrive one at a time. At each step, the newly arrived vertex forms a singleton clique, and the algorithm can merge any existing cliques in its partitioning into larger cliques, but splitting cliques is not allowed. We give an online algorithm with competitive ratio 15.645 and we prove a lower bound of 6 on the competitive ratio, improving the previous respective bounds of 31 and 2.
PREDICATION OF PATH IN FRENCH AND JAPANESE

Typological investigations by Talmy (e.g. 1985, 1991) have shed much light on how a universal semantics of motion events underlies the crosslinguistic expression of such events in syntax. Semantic elements that play important roles in motion events include the PATH of a moving object and its MANNER of motion. Talmy highlights a two-way typological distinction: (i) ‘verb-framed’ languages canonically encode PATH in the verb, whilst (ii) ‘satellite-framed’ languages encode PATH in a ‘satellite’ to the verb (e.g. an adposition). This is illustrated in the following French examples, where (ii) is ungrammatical on a PATH reading: (i) La fille a descendu la colline en dansant (the girl went-down the hill dancing); (ii) *La fille a danse en bas de la colline (the girl danced down the hill). With reference to examples from French and Japanese, I maintain that this typological distinction only holds where the PATH has a boundary or endpoint. Adapting both Emonds’ (1991, 2000) extension of subcategorization theory and Jackendoff’s (1991, 1996) analysis of boundedness as a conceptual feature, I suggest that boundedness can be formally expressed as a syntactic feature [±b], and show that French and Japanese allow the lexicalization of [PATH, -b] in P (e.g. towards), but exclude P [PATH, +b] (e.g. across). In addition, the feature [PATH] must be carried on closed-class or semi-lexical predicates (adpostions and ‘basic motion verbs’ such as go-up, go-down, cross, etc.). Apparent counterexamples in Italian serve to illustrate the morphosyntactic nature of [±b]. The complex preposition giu per (‘down’) may combine with MANNER verbs as the boundedness specification is determined by per (‘through’), which is inherently [-b]. I conclude that the interaction of the syntactic features [±PATH] and [±b] on verbal and prepositional predicates can account for much of the semantics of motion events in at least Japanese, Romance and English.
A parametric study on IBR sheeting supported by purlins

ii ACKNOWLEDGEMENTS . iii CONTENTS . iv LIST OF FIGURES . vii LIST OF TABLES . ix LIST OF SYMBOLS . x ABBREVIATIONS, ACRONYMS AND GLOSSARY . xii 1: INTRODUCTION . 1 1.1 Background . 1 1.2 Introduction to roof components used in the research . 2 1.2. 1 Overview of what makes up a steel roof . 2 1.2. 2 Description of a purlin . 4 1.2. 3 Description of an inverted box rib sheet (IBR) . 5 1.2. 4 Description of the fasteners . 6 1.3 Statement of the problem . 6 1.4 Significance of the research . 6 1.5 Research objectives . 7 1.6 Definitions of the terms used . 7 1.7 Structure of the document . 7
Tests of multivariate hypotheses when using multiple imputation for missing data and disclosure limitation

Several statistical agencies use, or are considering the use of, multiple imputation to limit the risk of disclosing respondents’ identities or sensitive attributes in public use data files. For example, agencies can release partially synthetic datasets, comprising the units originally surveyed with some values, such as sensitive values at high risk of disclosure or values of key identifiers, replaced with multiple imputations. This can be coupled with multiple imputation for missing data in a two-stage imputation approach. First the agency fills in the missing data to generate m completed datasets, then replaces sensitive or identifying values in each completed dataset with n imputed values. Methods for obtaining inferences with the mn datasets have been developed for scalar quantities, but not for multivariate quantities. We present methods for testing multivariate null hypotheses with such datasets. We illustrate the tests using public use files for the Survey of Income and Program Participation that were created with the two-stage imputation approach.
Root growth inhibition by NH4+ in Arabidopsis is mediated by the root tip and is linked to NH4+ efflux and GMPase activity

Root growth in higher plants is sensitive to excess ammonium (NH4). Our study shows that contact of NH4 with the primary root tip is both necessary and sufficient to the development of arrested root growth under NH4 nutrition in Arabidopsis. We show that cell elongation and not cell division is the principal target in the NH4 inhibition of primary root growth. Mutant and expression analyses using DR5:GUS revealed that the growth inhibition is furthermore independent of auxin and ethylene signalling. NH4 fluxes along the primary root, measured using the Scanning Ion-selective Electrode Technique, revealed a significant stimulation of NH4 efflux at the elongation zone following treatment with elevated NH4, coincident with the inhibition of root elongation. Stimulation of NH4 efflux and inhibition of cell expansion were significantly more pronounced in the NH4-hypersensitive mutant vtc1-1, deficient in the enzyme GDP-mannose pyrophosphorylase (GMPase). We conclude that both restricted transmembrane NH4 fluxes and proper functioning of GMPase in roots are critical to minimizing the severity of the NH4 toxicity response in Arabidopsis. Key-words: abiotic stress; ammonium toxicity; cell elongation; flux; N-glycosylation; root system.
Moving Path Following Control System for Fixed-Wing Unmanned Aerial Vehicles

This thesis introduces the Moving Path Following (MPF) problem where a vehicle is required to converge to and follow a desired geometric path, that moves according to some specified linear and angular velocity, thus generalizing the classical problem of following stationary paths. In the proposed approach to solve the problem, a MPF error dynamical system for the general case of time varying paths in a three-dimensional space is derived for a fixed-wing Unmanned Aerial Vehicle (UAV). Subsequently, distinct application scenarios for the MPF method are considered. First, the problem of tracking single and multiple targets on the ground using a UAV flying at constant altitude is addressed. To this end, a path generation algorithm is proposed together with a two-dimensional Lyapunov based MPF control law. Formal convergence guarantees, a performance metric and flight tests results are presented. A second application studied is the problem of convoy protection missions using a fixedwing UAV with a camera onboard whose field of view is smaller than the UAV minimum turning radius. The previously derived two-dimensional MPF control law is used together with a guidance algorithmic strategy in order to make a fixed-wing UAV converge to and follow a desired geometric moving path that is attached to the convoy center. Conditions under which the proposed strategy solves the convoy protection problem are derived. A performance metric and numerical simulation results demonstrate the effectiveness of the proposed approach. Finally, a general three-dimensional MPF quaternion-based control law is derived at kinematic level. Formal convergence proofs are provided. The proposed method is validated through numerical and flight test results, considering the mission scenario of autonomous landing on a moving vessel. The flight tests presented here took place in the Ota air base and the Santa Cruz airfield, in Portugal, using the ANTEX-X02 UAV.
Multiplicatively Weighted Crystal Growth Voronoi Diagrams

Voronoi diagrams and variants of Voronoi diagrams have been used for many years to model crystal growth. If the boundary of the growing crystals are circular and all the crystals start at the same time and have the same constant growth rate, then the Voronoi diagram is used to model the growth. If the crystals start at different times, the additively weighted Voronoi diagram is used to model the crystal growth. In this thesis, I propose a new type of Voronoi diagram, called the multiplicatively weighted crystal growth Voronoi diagram, that can be used to model crystal growth when the crystals have different constant growth rates. In this new model, the distance from a site to a point in its region is measured along a shortest path lying entirely within the region. In the multiplicatively weighted crystal growth Voronoi diagram, a growing crystal (or region) may "wrap around" another site's region. When a region wraps around, distances from the site are in part measured along the boundary of the two regions, treating one of the regions as an obstacle, rather than along a straight line that passes through the region. The worst case size of the multiplicatively weighted crystal growth Voronoi diagram is $\Theta(n\sp2)$. To construct the diagram, techniques from numerical analysis are used to approximate and to intersect curves described by a system of first order differential equations. Numerical methods to approximate a curve construct a polygonal approximation of the curve. One step of the numerical methods constructs an edge of the polygonal approximation. In the new Voronoi diagram, a step may require $\Theta(n)$ constant time operations. Let S be the number of steps required by the numerical method used just to draw the diagram. In the worst case, the algorithm presented in this thesis requires $O(n\sp3)$ intersection calculations plus O(nS lg S) time using $O(n\sp3$ + S) space. A variant of this algorithm requires $O(n\sp3)$ intersection calculations plus $O(nS\sp2$ + $n\sp2S)$ time using $O(n\sp2)$ space. Also presented are some variants of the new Voronoi diagram. One of these variants uses a convex polygon distance function. The multiplicatively weighted crystal growth Voronoi diagram using a convex polygon distance function does not require numerical methods to construct.
Integration of Digital/Blended Pedagogy and a Data Acquisition System to Enhance Anatomy and Physiology Laboratory Teaching for Allied Health Students: A Learner‐Centric Strategy

Undergraduate science laboratory teaching can be challenging and complex with millennial students, whose preparedness and expectations may be varied and at times misaligned with course goals and learning outcomes. This workshop presentation focuses on the use of innovative multimedia content and a data acquisition system to support several pedagogical strategies, including blended instruction and just in time teaching, designed to engage students and facilitate active learning. Anatomy and Physiology (A&P) laboratory exercises require a good balance of content and effective delivery methodology to streamline student learning and enhance student comprehension. Transforming undergraduate teaching labs in A&P is particularly important because students have a unique opportunity to learn collaboratively with their peers and participate as subjects in the collection of human physiological data. Students often struggle to connect specific physiological data to big picture concepts. Thus, engaging students before, during and after lab is an important strategy. The author will present examples from a laboratory curriculum that incorporates digital data acquisition and analysis coupled with customized content to maintain continuity of student learning between lecture and laboratory. In particular, the author will share lessons created on AD Instruments’ latest cloud based authoring/recording software solution called Lt. The ability to curate multimedia content, multi‐format assessment questions and grading is a powerful yet flexible way to design custom lessons and labs on Lt platform. These approaches enable students to integrate basic science knowledge and apply it clinically. The author will also share survey results and student comments about their experiences with this customized blended lab curriculum.
How to Communicate Chemical Knowledge? - A Qualification Course for PhD Students of Chemistry@@@How to Communicate Chemical Knowledge? - A Qualification Course for PhD Students of Chemistry

Scientists must not only undertake research, but also convey their knowledge to different people. For this reason, the professionalisation of doctoral candidates requires them to be trained in skills needed for teaching specific subjects. The project described here focuses on the training of skills needed by PhD students for communicating chemical knowledge. In the study, the typical teaching tasks undertaken by chemists were first drawn up. Also, a model of the teaching skills needed by scientists was developed and then adapted specifically to chemistry. This model serves as a basis for designing a course qualifying participants to transfer chemical knowledge. This was developed, tested and evaluated in line with the design-based research approach.
Differential interferometry in planar waveguide structures with ferronematic layer

The paper presents a differential interferometry phenomenon in a planar optical structure, which uses a ferronematic layer of a liquid crystal. This layer changes propagation conditions for TM modes in external magnetic field. Due to the magnetic field action on a ferronematic layer which covers the planar waveguide coated with an additional orientative layer, the ellipsoid of the refractive index changes its orientation in a polarization plane of the TM mode. In consequence, the phase difference of the TM mode occurs under magnetic field influence. This paper provides an analysis of the influence of a thickness and a refractive index of the orientative layer on interference phenomenon in analyzed structure.
Approaches to parameter and variance estimation in generalized linear models

EUGENIO ANDRACA CARRERA: Approaches to parameter and variance estimation in generalized linear models. (Under the direction of Bahjat Qaqish.) In many studies of clustered binary data, it is reasonable to consider models in which both response probability and cluster size are related to unobserved random effects. Two resampling methods have been recently proposed in the literature for mean parameter estimation in this setting: within-cluster resampling (WCR) and within-cluster paired resampling (WCPR). These procedures are believed to provide valid estimates in the presence of nonignorable cluster size. We identify the parameters estimated under WCR and under unweighted generalized estimating equations and elaborate on their differences and validity. We propose a simple weighted generalized estimating equations strategy that is asymptotically equivalent to WCPR but avoids the intensive computation involved in WCPR. We investigate the parameter estimated by WCPR for a generalized mixed model. We show that the parameter estimated by WCPR may be affected by factors other than the actual effects of exposure and propose an alternative strategy for the analysis of correlated binary data with cluster-specific intercepts based on simple generalized estimating equations for random intercept-matched pairs. We study the problem of variance estimation in small samples using robust or sandwich variance estimators. Robust variance estimators are widely used in linear regression with heteroscedastic errors, generalized linear models with possibly misspecified variance model, and generalized estimating equations. In these settings, the robust variance estimator provides asymptotically consistent estimates of the covariance matrix of mean parameters. However, the robust variance estimator may severely underestimate the
The CO envelope of IRC + 10216

New observations are reported of the J = 1-0 and J = 2-1 lines of CO in the envelope of IRC +10216. CO is detected out to about 200 sec from the star. For an assumed distance of 200 pc, the radius of the CO envelope is 6 x 10 to the 17th cm, and the time scale for intense mass loss is at least 14,000 yr. The observed CO line widths decrease in the outer envelope as expected for a radially expanding wind. Thermal models of the gas yield temperatures and CO densities for the inner envelope similar to those found earlier by Kwan and Linke (1982). The simplest models, however, underestimate the CO emission in the outer envelope. One possibility discussed is the effect of the interstellar radiation field, which can raise the kinetic temperature of the outer envelope and photodissociate CO at a characteristic radius similar to that of the observed CO source. A model including both these effects is in reasonable agreement with the observations. Other possibilities which may affect the CO emission are also discussed. 27 references.