Miracle-dz/UniFAR-FTUs huggingface dataset:
Ribosome recycling factor ABCE1 depletion inhibits nonsense-mediated mRNA decay by promoting stop codon readthrough

Nonsense-mediated mRNA decay (NMD) is an essential post-transcriptional surveillance pathway in vertebrates that appears to be mechanistically linked with translation termination. To gain more insight into this connection, we interfered with translation termination by depleting human cells of the ribosome recycling factor ABCE1, which resulted in an upregulation of many but not all endogenous NMD-sensitive mRNAs. Notably, the suppression of NMD on these mRNAs occurs at a step prior to their SMG6-mediated endonucleolytic cleavage. Ribosome profiling revealed that ABCE1 depletion results in ribosome stalling at stop codons and increased ribosome occupancy in 3’ UTRs, indicative of enhanced stop codon readthrough or re-initiation. Using reporter genes, we further demonstrate that the absence of ABCE1 indeed increases the rate of readthrough, which would explain the observed NMD inhibition, since enhanced readthrough has been previously shown to render NMD-sensitive transcripts resistant to NMD by displacing NMD triggering factors like UPF1 and exon junction complexes (EJCs) from the 3’ UTR. Collectively, our results show that improper ribosome disassembly interferes with proper NMD activation. Highlights ABCE1 knockdown suppresses NMD of many NMD-sensitive mRNAs The observed NMD inhibition occurs at a stage prior to SMG6-mediated cleavage of the mRNA ABCE1 depletion enhances ribosome occupancy at stop codons and in the 3’ UTR ABCE1 depletion enhances readthrough of the stop codon Enhanced readthrough inhibits NMD, presumably by clearing the 3’ UTR of NMD factors
Settlement, development, despoilment, and recovery of the Hudson River, New York

The mid-nineteenth century Hudson River School of painting reflects artists' views of American paradise, a glorified Hudson River landscape where the disappearing wilderness, agriculture, and human settlements coexisted along the river in perfect harmony. The romantic, peaceful coexistence of nature and humans became an unsustainable illusion as the twentieth century 507 km (315 mi) Hudson River became a major transportation route to the northern and western interior of the United States (figure 1). Like many rivers throughout history, navigation of the Hudson River waters fostered tanneries, paper mills, factories, electrical plants, and other enterprises along its coastline (Rothstein 2019). Rivers, with their abundant water supply and capacity to transport raw materials and finished goods, fueled the Industrial Revolution of the 1800s, and the Hudson River was exemplary in its contributions. Settlements and industries along the Hudson River valley flourished, creating jobs, expanding communities, and bringing economic prosperity to the region and the nation. In its wake, followed an era of industrial pollution that left an ugly mark on the river celebrated for its beauty and pristine waters. In 1984, 321 km (200 mi) of the Hudson River was classified by the US Environmental Protection Agency (USEPA) as the Hudson River…
The Feminization of Transgender Women in Prisons for Men: How Prison as a Total Institution Shapes Gender

In this article, we investigate the degree to which prison shapes transgender women’s perceptions of themselves as gendered people in prisons for men. Drawing on original data collected from 315 transgender women in 27 prisons for men in California, a mixed-methods analysis reveals that transgender women in prisons for men report higher levels of self-perceptions of femininity while incarcerated, especially for those who report sexual victimization by other prisoners. The implications of these and other findings are discussed in light of recent calls for more theory and research on femininities as well as the policies and practices that undergird prisons as one of the most sex-segregated institutions.
The business model of intelligent manufacturing with Internet of Things and machine learning

ABSTRACT To establish a business model of intelligent manufacturing, the sequence Generative Adversarial Network (SeqGAN) was used to optimise the Back Propagation (BP) neural network algorithm improved by multi-objective Genetic Algorithm to propose the sequence Generative Adversarial Network-Genetic Algorithm Back Propagation Algorithm (SeqGAN-GABP). Meanwhile, the Elman algorithm was optimised by the SeqGAN model to propose the SeqGAN-Elman algorithm. The algorithms were constructed and trained and were applied to the Internet of Things platforms. The results showed that the SeqGAN-GABP algorithm outperforms the SeqGAN-Elman algorithm in terms of minimal error, fitting accuracy, training time and internal memory usage.
Deductive Development and Validation of a Questionnaire to Assess Sensitivity to Very Low and Very High Frequency Sounds: SISUS-Q (Sensitivity to Infra-Sound and Ultra-Sound Questionnaire)

Objective: Auditory research and complaints about environmental noise indicate that there exists a significant, small subgroup within the population which is sensitive towards infra- and low-frequency or ultra- and high-frequency sounds (ILF/UHF). This paper reports on the development, factorization and validation of measures of sensitivity towards frequencies outside the common hearing range. Design: A multinational, cross-sectional survey study was run. Principal component analyses and exploratory factor analyses were conducted in a sample of 267 Europeans (from the UK, Slovenia, and Germany). Results: The factor analyses suggested that ILF versus UHF sensitivity constitute different factors, each characterized by sensory perception, stress-responsivity, and behavioral avoidance. A third factor comprising beliefs of dangerousness of ILF and UHF emerged. The factors explained 72% of the variance. The factor-solution was replicated separately for the English (n = 98) and German (n = 169) versions of the questionnaire (Slovenians and UK residents filled out the English version). Acceptable to excellent reliability was found. ILF and UHF sensitivity were moderately related to noise sensitivity in the normal hearing range, suggesting the new measures are not redundant. Correlations with psychiatric and somatic symptoms were small to moderate. ILF sensitivity correlated with neuroticism (small effect) and daytime sleepiness (moderate effect). ILF and UHF sensitivity were related to agreeableness (small effects). Overall, the novel ILF and UHF sensitivity scales seems to provide a solid tool for conducting further research on the role of sensitivity concerning adverse effects of ILF and UHF sound (e.g. health outcomes, annoyance ratings). The questionnaire consortium recommends using the new scales in combination with established measures of normal hearing range sensitivity.
A Wideband Series-Fed Circularly Polarized Differential Antenna by Using Crossed Open Slot-Pairs

A novel method of designing a wideband series-fed circularly polarized (CP) differential antenna by using crossed open slot pairs is presented in this article. The near-field distributions and input impedance analyses show that the closely spaced open slot-pairs can radiate as the crossed dipoles and have stable radiating resistance with a compact radiator size. Besides, a wideband half-power phase shifter using open slot is proposed and utilized to realize CP radiation. The proposed CP antenna is composed of a wide slot-pair and a narrow slot-pair. In the antenna design, the narrow slot-pair is not only excited as a radiator, but also elaborately loaded to provide wideband half-power output and quadrature phase excitation to the wide slot-pair. Both the proposed half-power phase shifter and CP antenna are illustrated by the corresponding equivalent circuits. Based on these analyses, the proposed antenna is designed, fabricated, and measured. Compared with the simulated traditionally designed counterpart, 2.1 times wider axial ratio (AR) bandwidth is achieved for the proposed antenna. The measured overlapped bandwidth for AR < 3 dB and return loss >10 dB is 1.95–3.45 GHz (55.6%). Also, the antenna gain and radiation patterns are measured, which agree well with the simulated results.
ALPPL2 Is a Highly Specific and Targetable Tumor Cell Surface Antigen

These findings identify ALPP2 as a true tumor-specific cell surface antigen whose tissue specificity enables the development of novel therapies. Identification of tumor-specific cell surface antigens has proven challenging, as the vast majority of tumor-associated antigens are also expressed in normal tissues. In mesothelioma, we identified a highly specific tumor cell surface antigen that can be targeted for therapy development. Mesothelioma is caused by malignant transformation of the mesothelium, is incurable, and can be categorized into three histologic subtypes: epithelioid, biphasic, and sarcomatoid. To identity novel mesothelioma cell surface antigens with broad subtype coverage and high tissue specificity, we have previously selected phage antibody display libraries on live mesothelioma cells and tissues following counterselection on normal cells and identified a panel of human antibodies that bind all subtypes of mesothelioma, but not normal mesothelium. One of the antibodies, M25, showed high specificity against an antigen we identify here as ALPPL2. IHC on normal human tissues found that ALPPL2 is expressed only on placental trophoblasts, but not on any other normal tissues. This significant tissue specificity and broad tumor type coverage suggest that ALPPL2 could be an excellent cell surface target for therapeutic development against mesothelioma. To evaluate therapeutic potential of ALPPL2 targeting, an ALPPL2-targeted antibody–drug conjugate was developed and demonstrated potent and specific tumor killing in vitro and in vivo against both epithelioid and sarcomatoid mesothelioma. Thus, ALPPL2 belongs to a rare class of cell surface antigens classified as truly tumor specific and is well suited for therapy development against ALPPL2-expressing tumors. Significance: These findings identify ALPP2 as a true tumor-specific cell surface antigen whose tissue specificity enables the development of novel therapies.
Coordinative Low-Voltage-Ride-Through Control for the Wind-Photovoltaic Hybrid Generation System

The wind-photovoltaic (PV) hybrid renewable energy system (HRES), which consists of permanent-magnet synchronous generators (PMSG) and PV arrays, is becoming a cost-effective electric source for powering islanded areas. However, high penetration of renewables makes the power system vulnerable to transient voltage faults, which undermines the stability of the future inverter-dominated grid. To address this issue, a coordinative low-voltage-ride-through (LVRT) control scheme is proposed for the operation of the wind-PV HRES in this article. This control scheme will exploit the maximum energy inertia of the HRES for incorporating the power imbalance between the faulted grid and the renewable generators. An optimization problem is formulated to maximize the renewable energy harvesting within the operational and environmental limitations. To cope with different working conditions, four control processes are coordinated in an optimized manner during the LVRT period: 1) adaptive dc-link voltage control; 2) PMSG rotating speed control; 3) PV energy curtailment control; and 4) blade pitch angle control. Besides, this control scheme applies a direct output control that can generate stable and accurate current as per grid code requirements. The results of the hardware-in-the-loop (HIL) experiment and the MATLAB/Simulink simulation are provided to verify the effectiveness of the proposed control scheme.
Hajj Fund Management in Perspective of the Financial Theory and Fiqh

With the separation of the management of the hajj funds of the Ministry of Religion to the BPKH, it still leaves some differences in view, related to the amount of the initial deposit charged by Jemaah who are members of the waiting list with a vulnerable period of 5 25 years. In addition, there is also a debate related to the use of initial deposit funds for the pilgrims to be dispatched, because BPKH until now must optimize the pilgrimage funds. The community still understands if the initial deposit fund deposited for them is an investment that should be able to continue to grow and be enjoyed by each congregation. The longer the congregation waits for the pilgrimage, the understanding is that the funds returned to the congregation in the form of optimizing the initial deposit must be even higher. But some views assume, the affairs of the pilgrimage are not a matter of investment, but purely to worship God. Related to the length of timing a person goes on the pilgrimage is purely based on the Jemaah departure quota that is limited by the government of Saudi Arabia to Indonesia. In this perspective, researchers feel the need for a study related to Hajj fund entities in formal law and sharia law and finance. Thus it is hoped that this research can answer the current assumptions. Keywords-Hajj Fund Management, Financial Theory,
Arterial remodelling in palmar fascia and peculiarities of hand microhemodynamics in patients with dupuytren’s contracture-Arterial remodelling in dupuytren’s contracture

Objective: To evaluate the structural changes of arteries in palmar fascia and peculiarities of microhemodynamics in hand arteries of Dupuytren’s contracture (DC) patients. Materials and methods: A cross-sectional study that included patients with DC. The samples of pathologically changed palmar fascia which was excised operatively during partial fasciectomy (DC, n=49). Control group – histologic samples of normal palmar fascia from patients with open wounds (n=3). Depending on the number of layers of smooth muscle cells in media in transverse histologic sections, arteries divided into large (L), medium (M) and small (S) calibers and were measured using computed planimetry. 15 healthy volunteers (men aged between 40 and 67 years) and 10 patients with DC (men aged between 45 and 70 years) before the operation were recruited randomly to carry out the study of hemodynamics in superficial palmar arc and proper palmar digital arteries by pulsed ultrasound Doppler velocimetry (PUDVM). Results: In S-arteries the luminal diameter was decreased predominantly due to intimal thickening. In M-arteries besides intimal thickening, the outer diameter and muscular layer thickness increased. In L-arteries the outer and lumen diameters decreased, but intimal thickness also increased due to neo-intima formation. Retrograde blood flow, negative values of diastolic velocity, decrease of all calculated PUDVM values were observed in all DC patients. The most expressed decrease of values and indices was noted in zones affected with disease (proper palmar digital arteries for ring and small fingers and superficial palmar arc). Conclusion: Hemodynamic signs of vasoconstriction at the level of superficial palmar were in accordance with structural constrictive remodeling of perforating palmar fascia arteries, the severity of the last depended on the stage of Dupuytren’s contracture and arterial caliber. Correspondence to: Shchudlo N, DM, head of clinical and experimental laboratory for reconstructive and restorative microsurgery and hand surgery, Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics of the RF ministry of health, M. Ulianova street 6, 640014, Kurgan, Russia, Tel: 89225631752; E-mail: nshchudlo@mail.ru
Design and analysis of a proposed transformerless/non-isolated high-‎gain DC-DC converter for renewable energy applications

ABSTRACT This paper proposes a transformerless/non-isolated, high-gain DC-DC converter required to increase low voltages in renewable energy applications. The converter topology uses only a single-switch with minimum voltage stress over the semiconductors. The design is obtained by integrating both the boost and the quadratic boost converter topology. Operating principles of the converter circuit topology are detailed, and the steady-state performance is analysed. The design results in lower switching voltage that significantly improves the efficiency of the controlled switches. The results obtained by computer simulation demonstrate that the high voltage gain is obtained at lower values of duty ratio with an efficiency of more than 94%. The merits of the proposed converter are given in comparison with other high-gain DC-DC converters. Finally, a laboratory model is built using the digital signal processor [dSPACE (DS-1104)] to verify the converter theory. The theoretical, simulation and experimental results that indicate the claimed converter performance and capability are given.
HUMAN DEVELOPMENT ANALYSIS: THE ROLE OF DEMOGRAPHIC FACTORS IN WEST NUSA TENGGARA IN THE PERIOD OF 2013 - 2017

The increasingly demands of globalization encourage various regions to compete in improving the welfare of their people. One effort to achieve it is in the demographic sector, namely by improving the quality of Human Resources (HR). A good quality of HR will boost the pace of the Human Development Index (HDI), which is common indicator of the development of a region. West Nusa Tenggara Province which has a low HDI but has potential in its community. By utilizing the panel data model, the analysis of this study took sample data from year 2013 to 2017, and aims to determine the effect of demographic factors, namely population density, open unemployment, fertility and productive age as independent variables toward HDI as a dependent variable in West Nusa Tenggara. The empirical results of this study indicate that the population density variable has a positive association on HDI while unemployment and fertility have a negative relationship on HDI in West Nusa Tenggara. Keywords : Human Resources (HR), HDI, demography, stunting, panel data
Altitudinal Distribution of Meltwater and Its Effects on Glacio‐Hydrology in Glacierized Catchments, Central Asia

In glacierized catchments, elevation is correlated with meltwater through its association with temperature, precipitation, and glacier hypsometry. The revelation of the altitudinal distribution of meltwater, unattended and not fully understood in previous work, might provide a better understanding of climate change impacts on glacio‐hydrology. Here, critical zone approach was defined and applied in 12 glacierized catchments of the Tien Shan–Pamir–Karakorum Mountains, Central Asia using manually calibrated glacier‐enhanced Soil and Water Assessment Tool model over 1966–2005. The critical zone, a sequence of elevation bands with above‐average snow and glacier melt, contributes maximum meltwater to total runoff. The critical zone shared 37%–95% (average = 80%) of meltwater contributions to total runoff, although its size was only 13%–30% of the total elevational relief. The critical zone controlled 76% and 82% variability in relative changes of glacier area and total runoff at the catchment scale, respectively. The increase in temperature was identified as the dominant driver for variations in total runoff in all catchments except Vakhsh and Yurungkash, where precipitation change remained dominant. Overall, glacier hypsometry limited the first‐order control of meltwater distributions on glacio‐hydrology. It is concluded that critical zone approach can interpret the proxy role of elevation to affect water availability under climate and glacier area change in glacierized catchments.
Active lifestyle promotion with home-based exercise in breast cancer survivors

Background: In cancer survivors, quality of life, weight management and physical activity levels are growing areas of interest, also considering such parameters may offer protection to cancer recurrence. Research question: In this study we aimed to objectively verify whether an home-based exercise program is effective in weight management of a cohort of breast-cancer survivors. Type of study: Experimental cohort observational study. Methods: We enrolled 13 women (age 49.1±5.5, height 163±7.3 cm) and evaluated habitual physical activity levels. Afterwards we compared the baseline aerobic capacity by 6 Minutes Walking Test (6MWT), flexibility, grip and lower limbs strength and body composition, to the same parameters measured after 40 days of unsupervised exercise. Results: At baseline (T0), patients displayed a moderate level of physical activity and were overweight. After 40 days of unsupervised exercise (T1), we observed improvement of all analyzed parameters with statistical significance in waist circumference (T0=0.57±0.1 cm, T1=0.55±0.1 cm; p<0.01), distance walked in 6 MWT (T0445.4±168.1 m, T1=534.6±151.5 m; p<0.05), 30 '' Chair test (T0=14.8±5.6 rep, T1=16.3±4.9 rep; p<0.05). Conclusions: Home-based unsupervised exercise in breast-cancer survivors yielded short-term efficacy in all analyzed parameters. Efficacy at long-term and a possible effect in reducing the risk of tumor relapse remain to be elucidated in larger cohorts with longer and multidisciplinary follow up.
Protection of Turbidity on Reefs along the Southeast Coast of the Kalimantan during the 2015 El Niño

Coral reef, the most diverse and highly valuable marine ecosystem, may be influenced by bleaching. This study aimed to determine the effect of turbidity on the severity of coral bleaching and mortality due to thermal stress and high solar irradiation caused by the 2015 El Nino event. Coral colonies in eighteen permanent bleaching belt transects (50 m x 1 m) in six sites were observed from June to November 2015, coinciding with the 2015 El Nino event. Environmental factors: water depth, sea surface temperature (SST), salinity, turbidity, sedimentation and total suspended solid (TSS) were measured on the same transect. The results of the study showed that the 2015 El Nino event was a major disaster for reefs on the southeast coast of the Kalimantan. Of total colonies (N = 12,954), 45.4% of colonies were bleached and 14.7% of colonies died during the period of July to November 2015. Turbidity, TSS, and sedimentation were negatively correlated with the bleaching mortality index (BMI). Coral bleaching in clear and deep waters occurred earlier and increased rapidly compared to that in turbid waters. However, the severity of coral bleaching in the turbid zone increased dramatically when the turbidity dropped to 5 NTU could provide shade, in which the proportion of dead corals was only 3.5%. The severity of coral bleaching in the turbid zone is not solely due to thermal stress and solar irradiation; it may also be influenced by a history of exposure to high turbidity and low salinity.