Miracle-dz/UniFAR-FTUs huggingface dataset:
Exclusion of angiotensinogen gene in molecular basis of human hypertension: sibpair linkage and association analyses in Australian anglo-caucasians.

Linkage with essential hypertension has been claimed for a microsatellite marker near the angiotensinogen gene (AGT; chromosome 1q42), as has association for the AGT variants M235T, G(-6)A and A(-20)C. To more rigorously evaluate AGT as a candidate gene for hypertension we performed sibpair analysis with multiple microsatellite markers surrounding this locus and using more sophisticated analysis programs. We also performed an association study of the AGT variants in unrelated subjects with a strong family history (two affected parents). For the linkage study, single and multiplex polymerase chain reaction (PCRs) and automated genescan analysis were conducted on DNA from 175 Australian Anglo-Celtic Caucasian hypertensives for the following markers: D1S2880-(2.1 cM)-D1S213-(2.8 cM)-D1S251-(6.5 cM)-AGT-(2.0 cM) -D1S235. Statistical evaluation of genotype data by nonparametric methods resulted in the following scores: Single-point analysis - SPLINK, P > 0.18; APM method, P > 0.25; ASPEX, MLOD < 0.28; SIB-PAIR, P > 0. 24; Multipoint analysis - MAPMAKER/SIBS, MLOD < 0.24; GENEHUNTER, P > 0.35. Exclusion scores of Lod -4.1 to -5.1 were obtained for these markers using MAPMAKER/SIBS for a lambda(s) of 1.6. The association study of G(-6)A, A(-20)C and M235T variants in 111 hypertensives with strong family history and 190 normotensives with no family history showed significant linkage disequilibrium between particular haplotypes, but we could find no association with hypertension. The present study therefore excludes AGT in the etiology of hypertension, at least in the population of Australian Anglo-Celtic Caucasians studied.
Possible enhancement of vincristine neuropathy by VP‐16

Eleven consecutive patients with small cell carcinoma of the lung treated intensively with a combination chemotherapy regimen cyclophosphamide, Adriamycin, VP‐16, and vincristine experienced peripheral neuropathy. Four of the 11 patients had severe (Grade III) neuropathy, leaving them virtually bedridden; the remaining seven patients had mild to moderate neuropathy. Only 8 of the 14 patients treated less intensively with vincristine and VP‐16 had Grade I and II neuropathy. Predisposing factors for severe neuropathy included advanced age and preexisting peripheral neuropathy. All patients' performance status declined and all lost much weight before developing neuropathy. From accumulated treatment experience of small cell carcinoma with vincristine alone or with vincristine, Adriamycin, cyclophosphamide combinations, the authors feel that the severe neuropathy observed was due to an interaction of vincristine and VP‐16. This conclusion is supported by electron microscopic observation of electron‐opaque granular degeneration of the myelin lamellae of affected nerve fibers.
Lahar: warehousing markovian streams

A huge amount of the world's data is both sequential and low-level. Many applications consume higher-level information, such as words and sentences, that is inferred from low-level sequences such as raw audio signals using a model (e.g., a hidden Markov model). This inference process is typically statistical, resulting in high-level streams that are imprecise. Common queries on this data include sequence-finding event queries (e.g. "Find all times when the phrase 'Barack Obama.veto' occurs in the NPR news podcast from July 9."), aggregates of these event queries (e.g. "How many times do 2008 NPR podcasts use the phrase 'Barack Obama.veto'? "), and queries on the lineage of event queries (e.g. "What words appeared between the word 'Obama' and 'veto' in the previous query? "). These queries are difficult to support efficiently because of the large volumes and rich semantics of imprecise data, but they are critical for allowing applications to effectively leverage the rich information contained in these imprecise streams. In this thesis, we introduce Lahar, the first database system for a common type of imprecise, sequential model called a Markovian stream. Lahar includes algorithms for efficiently processing event queries, aggregated event queries, and event query lineage. Lahar accelerates performance and scalability using several techniques, including a set of novel Markovian stream indices and novel methods for approximating Markovian streams. Through experiments on two real-world datasets (one collected from an office-building RFID deployment and the other collected from audio pod-casts) we demonstrate that Lahar is an efficient Markovian stream warehousing system.
Integrated two-beam antenna array featuring dual-circular polarization

A concept of an integrated antenna array featuring two independent beams and dual circular polarization has been described. The antenna array consists of two radiating elements which are excited at two orthogonally placed feeding ports with the use of four appropriately connected 3-dB/90° directional couplers. Therefore, such an array generates two symmetrically located beams having right-handed circular polarization (RHCP) and identical two beams having left-handed circular polarization (LHCP). The presented concept has been verified by the design and measurements of an antenna array operating at 2.4 GHz frequency range.
Treating post-CABG depression with telephone-delivered collaborative care: does patient age affect treatment and outcome?

OBJECTIVE To determine the nature of telephone-delivered collaborative care intervention provided to patients younger than and older than 60 years experiencing clinically significant depressive symptoms after coronary artery bypass graft (CABG) surgery and whether patient age is related to response and remission rates and delivery of care at 8-month follow-up. DESIGN : Exploratory post-hoc analysis of data collected in a randomized controlled trial (RCT). SETTING Seven Pittsburgh-area general hospitals. PARTICIPANTS Fifty-eight depressed post-CABG patients younger than 60 and 92 comparable patients age 60 years and older randomized to the RCT's intervention arm. MEASUREMENTS : Components of collaborative care provided to patients over the 8-month study period and Hamilton Rating Scale for Depression scores at 8-month follow-up to determine response and remission status. RESULTS There were no differences in the cumulative 8-month rates at which the components of collaborative care were delivered to the two age groups. Similar response and remission rates were also achieved by these groups. CONCLUSION Older and younger patients experiencing clinical depression after CABG surgery can be treated with comparable components of collaborative care, and both age groups will achieve clinical outcomes that do not differ significantly from each other.
A survey for planetary transits in the field of NGC 7789

We present results from 30 nights of observations of the open cluster NGC 7789 with the Wide Field Camera on the Isaac Newton Telescope, La Palma. From ∼900 epochs, we obtained light curves and Sloan r' - i' colours for ∼33 000 stars, with ∼2400 stars having better than 1 per cent precision. We expected to detect ∼2 transiting hot Jupiter planets if 1 per cent of stars host such a companion and a typical hot Jupiter radius is ∼ 1.2 R J . We find 24 transit candidates, 14 of which we can assign a period. We rule out the transiting planet model for 21 of these candidates using various robust arguments. For two candidates, we are unable to decide on their nature, although it seems most likely that they are eclipsing binaries as well. We have one candidate exhibiting a single eclipse, for which we derive a radius of 1.81 +0.09 -0.00 Rj. Three candidates remain that require follow-up observations in order to determine their nature.
REGIONAL EVALUATION OF BACTERIAL CONTAMINATION IN HOSPITAL ENVIRONMENT COCKROACHES

Cockroaches play an important role in transmission of different diseases either mechanically and occasionally biologically. The aim of current study was on the identification of cockroaches and their contamination to different bacteria in two hospitals affiliated to the Kordestan University of Medical Sciences which was performed in 2003. Cockroaches were collected from different parts using sticky traps, direct collection, and by means of vacuum cleaner. Collected cockroaches were identified according to the reliable systematic keys. Some of the collected cockroaches were selected randomly for the presence of bacteria in their external parts as well as in the digestive tract using specific culture media. Totally 450 specimens were collected. From which 44.4% identified as American Cockroach, Periplaneta Americana and remaining German cockroach, Blattella germanica . Among collected cockroaches 58 specimens of German cockroaches and 40 American cockroaches were selected to search for the presence of bacteria. Results of culture media exhibited that 89.8% (88.98) of cockroaches were positive to the bacteria. The bacteria were found mainly on external parts (67%) and remaining from alimentary canal. The main common bacteria was found Escherichia coli , however, only 5.1% was Escherichia sp. , which was found on external parts. Among two hospitals it is found that Tohid hospital was more infected (97.5%). In the hospitals the infectivity of American cockroaches was more prevalent than other species. All the American cockroaches and 70% of German cockroaches were infected to at least one bacterium. Result showed that the presence of cockroaches in the hospitals can threaten the health of hospitalized patients. Both cosmopolitan species was found infected in the hospitals. Sanitation of different departments as well as different method of control is recommended in the context of Integrated Vector Management for cockroach control.
Standardization-a new discipline?

Verman (1973) was the first to call standardization a discipline. But is it, or should it be, an academic discipline as well? In this contribution we will address this question. After a short introduction we roughly assess the maturity of standardization as a scientific discipline. Then, we choose a more fundamental approach. We map the field of current and possible scientific research by characterizing the standardization phenomenon and by confronting this with a systematic listing of sciences based on the philosophy of Dooyeweerd (1955, 1957) and, then, confronting this with current standardization literature. This enables us to distinguish some blank areas on the map of standardization research and it may form the basis for future systematic standardization research. Finally we answer the question whether or not standardization is or should be an academic discipline.
Evidence of linkage to psychosis on chromosome 5q33‐34 in pedigrees ascertained for bipolar disorder

It is hypothesized that the presence of psychotic features may define a subtype of bipolar disorder that is more homogeneous in its genetic predisposition than bipolar disorder as a whole. We used psychosis as an alternative phenotype definition in a re‐analysis of the NIMH Bipolar Genetics Initiative data sets. In this analysis we selected only those families in which at least two members were diagnosed with bipolar disorder type 1 with psychotic features. This analysis identified a linkage signal on chromosome 5q33‐q34, a region previously implicated in independent linkage studies of schizophrenia and of psychosis, broadly defined. This finding is consistent with the hypothesis that susceptibility to psychosis may characterize at least a subtype of bipolar disorder. © 2006 Wiley‐Liss, Inc.
A WARFARIN INDUCTION REGIMEN FOR OUT‐PATIENT ANTICOAGULATION IN PATIENTS WITH ATRIAL FIBRILLATION

Each treatment course with ABLC was preceded by therapy with amphotericin B at a dose of 1 mg/kg. The indications for amphotericin B were radiological features suggestive of invasive fungal infection (14 courses), pyrexia for >72 h despite broad-spectrum antibiotics (six courses) and microbiologically con finned candidaemia (two courses). Alteration of therapy to ABLC was instituted because of nephrotoxoicity, defined as an increase in serum creatinine by 50% above baseline levels (10 courses), unresponsive fungal disease (eight courses), hyperlhypokalaemia (two courses) and hepatic impairment (two courses), ABLC was used at a dose of 5 mglkg in all cases. Over all the treatment courses with ABLC, the mean serum creatinine at the initiation of therapy was 13 9 f. mol/I and at the end of therapy was 132 f. moi/l. For those 10 treatment courses were ABLC was indicated because of nephrotoxicity the mean initial serum creatinine was 177 f. mol/I and the mean final creatinine was 1 51 f. mol/l. Richardson. M. & Kokkl, M. (1998) Antifungal therapy in 'bone marrow failure'. British Journal of Hllematolo! J! J, 100.619-628.
Development and Validation of Method for the Estimation of Telmisartan as Active Pharmaceutical Ingredient in Tablet Dosage form and Prepared Spherical Agglomerates by RP-HPLC

The Present work was designed to develop and validate an accurate, precise and rapid method for the estimation of Telmisartan as Active Pharmaceutical Ingredient (API) as well as in tablet dosage form and prepared spherical agglomerates by RP-HPLC. The developed method was found to be simple, accurate, precise and sensitive. The separation was achieved on an Isocratic High Pressure Liquid Chromatography (HPLC) (Thermo Scientific) using pumps Jasco PU 2080 Plus, UV detector, column oven (Jasco), and a Reverse Phase C-18 (phenyl) Column (25 cm x 4.6 mm) i.d. , particle size 5 μm. The HPLC system was run with flow rate: 0.8 ml/min Injection Volume: 10μl and run time: 10 min, Detector temp: 40 oC. The method was validated for specificity, precision, linearity, and accuracy, robustness, LOD and LOQ parameters. The recovery range was within the range of 99.0–102.0% and the method could be successfully applied for the routine analysis of the drug substance as well as the spherical agglomerates prepared by crystallo coagglomeration technique.
Another security improvement over the Lin et al.'s electronic-voting scheme

Lin, Hwang and Chang (2003) have proposed an electronic-voting scheme which can be utilised in large-scale elections, and claimed that it detects double voting. In this article, by presenting an attack, we show that voters can successfully vote more than once without being detected. Then, we propose a new modified scheme based on the Lin, Hwang and Chang's (2003) scheme with the same efficiency to solve this weakness and analyse its security.
Exergaming for Health: A Randomized Study of Community-Based Exergaming Curriculum in Pediatric Weight Management.

OBJECTIVE To evaluate the effectiveness and sustainable impact of a multifaceted community-based weight intervention program for children, including exergaming curriculum. METHODS Eighty overweight or obese children, aged 8-12 years, were randomly assigned in a 2:1 ratio to an Exergaming for Health intervention group, comprising both exergaming and classroom curriculum, or to a control group with classroom curriculum alone. Outcome measures included body mass index (BMI), z-score change, and shuttle runs to assess cardiorespiratory endurance. RESULTS Fifty-nine participants took part in the intervention and 21 in the control group, with 35 and 13 completing 6-month follow-up, respectively. Twenty-eight intervention children were followed-up at 1 year. At the end of the 6-month intervention, the intervention group reduced its BMI z-score by -0.06 (±0.12) compared to 0 (±0.09) change for the control group; additionally, intervention subjects were two shuttle runs higher than control. However, these differences were not statistically significant (P = 0.07 and P = 0.09, respectively). Over the 6-month period after the program, the intervention group did not have an increase in weight status (BMI z-score change -0.01 [95% confidence interval -0.08 to +0.06], P = 0.76). CONCLUSIONS Use of exergaming in community pediatric weight management did not improve weight status at the end of programming, and study implementation was limited by small sample and missing data. However, there were clinically promising trends in fitness, screen time, and caloric intake. Weight status of intervention participants did not rebound 6 months after programming. Larger, longer term studies are needed to establish the impact of videogaming interventions.
Caregiver strain in spouses of stroke patients

Objective: To test the ability of a previously generated logistic regression model to predict caregiver strain from carer mood, negative affectivity and perceived patient functional ability. Design: Postal prospective survey. Setting: Spouses of community-residing patients identified from hospital stroke registers. Method: Spouses were assessed at three and six months after stroke. A previously derived equation was used to make predictions at three months of their level of strain at six months, which were compared with observed outcomes. Measures: Spouses were asked to complete the Caregiver Strain Index (CSI), the General Health Questionnaire (GHQ-12), the Positive and Negative Affectivity Schedule (PANAS) and to assess patients' independence in activities of daily living on the Extended Activities of Daily Living Scale (EADL). Results: Of 409 stroke patients, 276 had an identifiable co-resident spouse and 116 (42%) completed the measures. At three months after stroke, 39 carers (34%) were under significant strain with 40 (35%) under strain at six months. The predictive model using the GHQ-12, PANAS and EADL at three months was 78% accurate in predicting levels of caregiver strain at six months. Conclusion: Carers at risk of later strain could be identified for further followup. Services to provide emotional support to carers might be effective in the reduction of carer strain.
Biopesticides from Natural Products: Current Development, Legislative Framework, and Future Trends

The importance of biomass as a source of chemicals, biofuels, and energy is widely accepted. Currently, the attention is mainly focused on the valorisation of by-products from lignocellulosic materials. Chemical compounds derived from plants and microorganisms that provide good protection for crops against weeds, pests, and diseases (biopesticide active substances) have been used to formulate pesticides. Their use is increasingly encouraged by new pesticide regulations that discourage the use of harmful active substances. This article reviews the current and future situation of biopesticides, especially natural chemical products, and focuses on their potential within the European pesticide legislative framework. Moreover, this article highlights the importance of the different modes/mechanisms of action of the active substances obtained from natural sources, the role of chemistry in biopesticide development, and how the adoption of integrated pest management practices contributes to a greater trend towards biopesticides.
Effects of additives on surfactant phase behavior relevant to bacteriorhodopsin crystallization

The interactions leading to crystallization of the integral membrane protein bacteriorhodopsin solubilized in n‐octyl‐β‐D‐glucoside were investigated. Osmotic second virial coefficients (B22) were measured by self‐interaction chromatography using a wide range of additives and precipitants, including polyethylene glycol (PEG) and heptane‐1,2,3‐triol (HT). In all cases, attractive protein–detergent complex (PDC) interactions were observed near the surfactant cloud point temperature, and there is a correlation between the surfactant cloud point temperatures and PDC B22 values. Light scattering, isothermal titration calorimetry, and tensiometry reveal that although the underlying reasons for the patterns of interaction may be different for various combinations of precipitants and additives, surfactant phase behavior plays an important role in promoting crystallization. In most cases, solution conditions that led to crystallization fell within a similar range of slightly negative B22 values, suggesting that weakly attractive interactions are important as they are for soluble proteins. However, the sensitivity of the cloud point temperatures and resultant coexistence curves varied significantly as a function of precipitant type, which suggests that different types of forces are involved in driving phase separation depending on the precipitant used.
HPLC Profile of Captopril Disulfide That Undergoes Reversible cis-trans Conversion among Three Isomers

Peculiarly shaped chromatograms of some compounds that consist of two reversible isomers have been reported. Those of a compound that consists of three reversible isomers are described here. Because disulfide of captopril has two cis-trans convertible bonds, it exists in three forms of cis-cis, cis-trans and trans-trans isomers. The disulfide has produced various HPLC-UV profiles under various conditions, such as three split peaks, three peaks with bridging plateaus and one broad peak. The effect of the column temperature and the eluent flow rate on the profile was investigated and explained by interconversion among three isomers. A profile analysis could provide some kinetic constants of this reaction.
Exploring perceptions of web accessibility: a survey approach

The equality of access – accessibility – is difficult to quantify, define, or agree upon. Our previous work analysed the responses of web accessibility specialists in regard to a number of pre-defined definitions of accessibility. While uncovering much, this analysis did not allow us to quantify the communities’ understanding of the relationship accessibility has with other domains and assess how the community scopes accessibility. In this case, we asked over 300 people, with an interest in accessibility, to answer 33 questions surrounding the relationship between accessibility, user experience (UX), and usability; inclusion and exclusion; and evaluation, in an attempt to harmonise our understanding of web accessibility. We found that respondents think that accessibility and usability are highly related and also think that accessibility is applicable to everyone and not just people with disabilities. Respondents strongly agree that accessibility must be grounded on user-centred practices and that accessibility evaluation is more than just inspecting source code; however, they are divided as to whether training in ‘Web Content Accessibility Guidelines’ is necessary or not to assess accessibility. These perceptions are important for usability and UX professionals, developers of automated evaluation tools, and those practitioners running website evaluations.
More Effective Supervised Learning in Randomized Trees for Feature Recognition

This paper presents a feature recognition method based on randomized trees. We aim to improve the performance of Lepetit`s work [1], whose actual results are very sensitive to large changes of viewpoint due to its limited ability of samples synthesizing and learning. We propose an approach to alleviate its limitation, which simulates the image appearance changes under actual viewpoint changes by applying general projective transformations to the standard image rather than affine ones. Affine transformations are usually used in many state-of-the-arts but they cannot adequately represent the actual relationship between two images with different viewpoints. The result is a more effective way of supervised image sample learning in randomized trees for feature recognition that is robust to large changes of viewpoints.