Miracle-dz/UniFAR-FTUs huggingface dataset:
P-Waveform Receiver Functions

ABSTRACT: In this study, the crustal velocity structure and depth of Moho is determined under the eastern part of Iranian Kopeh Dagh, North-East Iran that is named Hezar-Masjed mountains. The teleseismic waveform receiver functions technique is used to determine crustal thicknesses in this study. 41 teleseismic earthquakes from three broadband seismometers installed in the Iranian Kopeh-Dagh, are used to calculate P-wave receiver functions. Receiver functions for each station are generated from events for a wide range of backazimuths. From analysis of receiver functions at KAR, ZOW and HAM stations, the crustal structure is suggested for the Hezar-Masjed area with a Moho depth of 44-50km. Results indicate three main layers; the upper crust has an S-wave velocity between 2.1-3.2km/s and a 10 to 12km thickness, a middle crust with S-wave velocity between 3.2-3.7km/s and a 22 to 25km thickness and the lower crust with S-wave velocity between 3.7-4.4km/s and a 12 to 15km thickness. An S wave velocity between 4.6-4.7km/s indicates the velocity of the Moho at 47km on average and varies from 44 to 50km. Deeper Moho is found under the southern station.
Has the digital environment been democratized ? : Digital uses in the non-electoral period of government parties vs . opposition parties in European countries and the Community of Portuguese Language Countries ( CPLP )

E tudo o digital democratizou? : Usos digitais em período não eleitoral dos partidos do governo vs. da oposição em países da Europa e da Comunidade dos Países de Língua Portuguesa (CPLP) Has the digital environment been democratized? : Digital uses in the nonelectoral period of government parties vs. opposition parties in European countries and the Community of Portuguese Language Countries (CPLP)
Pharmacokinetics of amikacin in plasma of healthy goats after intravenous injection once daily for three days

Amikacin is a semisynthetic derivative of kanamycin and primarily active against aerobic Gramnegative-pathogens with limited activity against Gram-positive bacteria. Meager study was reported on pharmacokinetic data on multi-days administration of amikacin. Hence, pharmacokinetics study was done in five clinically healthy goats (n = 5), after intravenous bolus injection of amikacin sulfate at the dose rate of 10 mg/kg body weight daily for three consecutive days. The amikacin concentrations in plasma and pharmacokinetics-parameters were analyzed by using microbiological assay technique and noncompartmental open-model, respectively. The mean peak plasma concentrations (Mean ± SD) of amikacin at time zero (Cp) was 114.19 ± 20.78 and 128.67 ± 14.37 μg/mL, on day 1st and 3rd, respectively. The mean elimination half-life (t1/2ke) was 1.00 ± 0.28 h on day 1st and 1.22 ± 0.29 h on day 3rd. Mean of area under concentration-time curve (AUC0→∞) was 158.26 ± 60.10 and 159.70 ± 22.74 μg. h/mL, on day 1st and 3rd respectively. The total body clearance (ClB) and volume of distribution at steady state (Vdss) on day 1st and 3rd were ClB = 0.07 ± 0.02 and 0.06 ± 0.01 L/h.kg and Vdss = 0.10 ± 0.03 and 0.11 ± 0.05 L/kg, respectively. No-significant difference was noted in both drug-plasma concentration and pharmacokinetics-parameters, respectively. Amikacin concentration in plasma was found higher up-to 4 h and 6 h onward on down-ward trends favour to reduce toxicity. Which also support the pharmacokineticpharmacodynamic way of dosing of aminoglycosides and hence, amikacin may be administered 10 mg/ kg intravenously daily to treat principally Gram-negative pathogens and limitedly Gram-positive-pathogens.
THE IMPACT OF COVID-19 PANDEMIC ON THE TOURISM SECTOR IN INDONESIA

The tourism is one of the strategic sectors and has an important role as a source of foreign exchange and encourages national economic growth. Since March 2020, the Covid-19 pandemic has begun to enter Indonesia, and the cumulative infection curve has not sloped, and is still increasing exponentially until now. This phenomenon has resulted in a contraction in the Indonesian economy or created negative economic growth, as well as creating very bad conditions for the tourism sector in Indonesia. This study aims to examine the influence of the Covid-19 pandemic on tourism and its implications for economic growth in Indonesia. The data used are quarterly time series data before and after the Covid-19 Pandemic (2018-2020). This study uses a regression equation model that is estimated by using ordinary least square (OLS). Secondary data used are data air transport and hotel accommodation, as a proxy for tourism variables. The results show that the Covid-19 Pandemic has a negative effect on Indonesian tourism, and has negative implications for Indonesia's GDP. From the simulation results, the findings of this study also calculate the amount of potential lost in the Turism and Indonesian economy during the Covid-19 Pandemic.
Protective effect of Celtis tournefortii against copper-induced toxicity in rat liver

This study aimed to investigate the antioxidant and hepatoprotective effects of Celtis tournefortii fruit extract (Ct) against copper-induced liver damage in rats. Thirty-two Wistar Albino rats were divided into four equal groups (n = 8): Control, Copper (Cu), Copper + C. tournefortii (Cu+Ct), and C. tournefortii (Ct). Superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities, glutathione (GSH) concentration, malondialdehyde (MDA), total antioxidant status (TAS) and total oxidant status (TOS) were analysed in the liver tissues. Liver histopathology was also evaluated. Alanine aminotransferase and lactate dehydrogenase significantly decreased in the Cu+Ct group compared with the Cu group. Oxidative stress parameters MDA and TOS significantly increased with copper administration, whereas they decreased with C. tournefortii co-treatment compared to Cu group. GSH concentration and TAS showed significant decreases with copper administration. Celtis tournefortii co-supplementation with copper significantly enhanced antioxidant parameters such as TAS, SOD, and GPx. Celtis tournefortii remarkably attenuated degenerative and necrotic changes caused by the oral exposure of copper in the liver tissue of rats. Celtis tournefortii may provide amelioration of the antioxidant status and moderation of severity of liver damage against copper toxicity. The therapeutic use of C. tournefortii may exhibit protective effects in liver injury treatment.
Studying during the COVID-19 Pandemic: Nursing Student’s Perspectives and Experiences in Saudi Arabia

The outbreak of the global and widespread COVID-19 pandemic extended to all nations and affected all races and socioeconomic categories Global crises like the COVID-19 pandemic my pose devastating impacts on the academic functioning and psychological wellbeing of students, specifically nursing students With such consideration, the current study focused on identifying the perceptions of nursing students towards the COVID-19 pandemic while also investigating some of their encounters while learning amid the pandemic Data saturation was obtained after analyzing filled questionnaires and answers from 123 interviews conducted through virtual calls Data was collected through analyzing the current literature and supplemented by surveys and virtual interviews online Analysis of the data collected provided 16 codes that depicted various student’s perceptions and experiences The participating nursing students answered questions pertaining to the ability of government institutions in controlling the virus They also answered positively to indicate the prevalence with which misinformation was propagated by social media sites Besides, the participants reported that the general populations did not follow the measures set by government’s institutions
Impact of Social Consumption Crisis Strategy on Distribution Marketplaces' Relationships

Purpose: This paper reviews the attitudes of consumers related to the consumption crisis response strategy (i.e., defensive vs. receptive) that companies implement during crises. Research design, data, and methodology: We discuss the interaction between the crisis response strategy and the consumption crisis type (i.e., corporate ability vs. corporate social responsibility). We used SAS ver. 9.4 software to analyze the results. We applied a 2 × 2 intergroup experimental design to our sample of subjects, who were undergraduate and graduate students at a university in Seoul, South Korea. The three experimental variables considered were the entity‟s risk response strategy, the crisis type, and public relations strategy. The experiments were conducted by presenting a hypothetical scenario to eight groups. Prior to this experiment, five preliminary surveys were conducted to determine the three variables just mentioned. Preliminary surveys were conducted on the basis of these criteria. For eight selected product lines, 320 undergraduates were required to enter the product lines that are frequently used in the assessment center up to the fourth priority. Results: Analysis of variance revealed that experiments related to crisis response strategy, type of enterprise crisis, and type of public relations message were successful. Conclusions: Our results verify the impact of different types of social initiatives on distribution marketplaces.
University of Southern Denmark Comprehensive analysis of DNA methylation and prediction of response to neoadjuvanttherapy in locally advanced rectal cancer Canto,

The treatment for locally advanced rectal carcinomas (LARC) is based on neoadjuvant chemoradiotherapy (nCRT) and surgery, which results in pathological complete response (pCR) in up to Cancers 2020, 12, 3079; doi:10.3390/cancers12113079 www.mdpi. com/journal/cancers Cancers 2020, 12, 3079 2 of 20 30% of patients. Since epigenetic changes may influence response to therapy, we aimed to identify DNA methylation markers predictive of pCR in LARC patients treated with nCRT. We used high-throughput DNA methylation analysis of 32 treatment-naïve LARC biopsies and five normal rectal tissues to explore the predictive value of differentially methylated (DM) CpGs. External validation was carried out with The Cancer Genome Atlas-Rectal Adenocarcinoma (TCGA-READ 99 cases). A classifier based on three-CpGs DM (linked to OBSL1, GPR1, and INSIG1 genes) was able to discriminate pCR from incomplete responders with high sensitivity and specificity. The methylation levels of the selected CpGs confirmed the predictive value of our classifier in 77 LARCs evaluated by bisulfite pyrosequencing. Evaluation of external datasets (TCGA-READ, GSE81006, GSE75546, and GSE39958) reproduced our results. As the three CpGs were mapped near to regulatory elements, we performed an integrative analysis in regions associated with predicted cis-regulatory elements. A positive and inverse correlation between DNA methylation and gene expression was found in two CpGs. We propose a novel predictive tool based on three CpGs potentially useful for pretreatment screening of LARC patients and guide the selection of treatment modality.
Effect of service quality and motivation on the consumption behavior of students in the academic services

Received Jun 11, 2020 Revised Dec 26, 2020 Accepted Jan 30, 2021 This study aimed to determine the effect of service quality and motivation to the consumption behavior of students in utilizing academic services. This research involved 87 students of Economic Education Study Program in University of Jambi, Indonesia. The data were analyzed using structural equation modeling with partial least squares technique (SEM-PLS). Student consumption behavior is an illustration of the level of satisfaction in utilizing academic services provided by universities. Satisfaction with academic services is a measure of the success of higher education performance in providing education. A good indicator of consumer behavior variables, namely making the University of Jambi academic services the best choice and choosing them as institutions of higher education to meet learning needs on an ongoing basis. The quality of academic services is shown by indicators of the reliability of officers in providing academic services, accuracy in the delivery of information, responsiveness in responding to complaints and student requests and harmonization of service relationships between officers and students. While consumption motivation is indicated by an indicator of trust in the services consumed it will facilitate the completion of academic affairs and the existence of attractive offers from higher education institutions. The quality of academic services has a significant effect on consumer behavior of students. Moreover, the consumption motivation variable is proven to be a significant mediator on the effect of service quality on student’s consumption behavior.
Patterns of Multimorbidity

Background: With multimorbidity becoming the norm rather than the exception, the management of multiple chronic diseases is a major challenge facing healthcare systems worldwide. Methods: Using a large, nationally representative database of electronic medical records from the United Kingdom spanning the years 2005 to 2016 and consisting over 4.5 million patients, we apply statistical methods and network analysis to identify comorbid pairs and triads of diseases and identify clusters of chronic conditions across different demographic groups. Unlike many previous studies, which generally adopt cross-sectional designs, we examine temporal changes in the patterns of multimorbidity. In addition, we perform survival analysis to examine the impact of multimorbidity on mortality. Results: The proportion of the population with multimorbidity has increased by approximately 2.5 percentage points over the last decade, with more than 17% having at least two chronic morbidities. We find that the prevalence and the severity of multimorbidity increase progressively with age. Stratifying by socioeconomic status, we find that people living in more deprived areas are more likely to be multimorbid compared to those living in more affluent areas at all ages. The same trend holds consistently for all years in our data. In addition to a number of strongly associated comorbid pairs (e.g., cardiac-vascular and cardiac-metabolic disorders), we identify three principal clusters: a respiratory cluster, a cardiovascular cluster, and a mixed cardiovascular-renal-metabolic cluster. These are supported by established pathophysiological mechanisms and shared risk factors, and are largely consistent with existing studies in the medical literature. Conclusions: In this paper, we use data-driven methods to characterize multimorbidity patterns in different demographic groups and their evolution over the past decade. Our findings contribute to the better understanding of the epidemiology of multimorbidity that is needed to develop more effective primary care for multimorbid patients.
Hospitals That Report Severe Sepsis and Septic Shock Bundle (SEP-1) Compliance Have More Structured Sepsis Performance Improvement

Objective: Sepsis is a common cause of death in hospitalized patients. The Centers for Medicare & Medicaid Service (CMS) Severe Sepsis and Septic Shock Bundle (SEP-1) is an evidence-based early management bundle focused on improving sepsis outcomes. It is unknown which quality improvement (QI) practices are associated with SEP-1 compliance and if those practices reduce sepsis mortality. The objectives of this study were to compare sepsis QI practices in SEP-1 reporting and non-reporting hospitals and to measure the association between specific elements of sepsis QI processes and SEP-1 performance and hospital-specific risk-adjusted sepsis mortality. Design, Setting, and Patients: This mixed methods study linked telephone survey data on QI practices from Iowa hospitals to SEP-1 performance data and risk-adjusted mortality from statewide all-payer administrative claims database. The survey assessed sepsis QI practices in eight categories. Characteristics of hospitals and sepsis QI practices were compared by SEP-1 reporting status. Univariable and multivariable logistic and linear regression estimated the association of QI practices with hospital SEP-1 performance and observed-to-expected sepsis mortality ratios. Interventions: None Measurements and Main Results: All 118 Iowa hospitals completed the survey (100% response rate). SEP-1 reporting hospitals were more likely to have sepsis QI practices, including reporting sepsis quality to providers (64% vs. 38%, p = 0.026) and using the case review process to develop sepsis care plans (87% vs. 64%, p = 0.013). Sepsis QI practices were not associated with increased SEP-1 scores. Two were associated with reduced mortality: having a sepsis committee B= -0.11, p = 0.036) and using case review results for sepsis care plans (B= -0.10, p = 0.049). Conclusions: Hospitals reporting SEP-1 compliance to CMS conduct more sepsis QI practices. Most QI practices are not associated with increased SEP-1 performance or decreased sepsis mortality. Future work could explore how to implement these performance improvement practices in hospitals not reporting SEP-1 compliance.
A High Performance Route for the Synthesis of Dihydropyrrolo[1,2‐f]phenanthridine Scaffolds by using a One‐pot Four‐component Reaction

Synthesis of a series pyridine containing dihydropyrrolo core fused phenanthridines by a one-pot four-component reaction in an efficient route is reported. This report contains the reaction of pyridinecarbaldehydes, malononitrile, and phenanthridine in the presence of alkyl isocyanides.
Colorimetric sensing of chromium(VI) ions in aqueous solution based on the leaching of protein-stabled gold nanoparticles

Herein, we developed a simple, sensitive and non-aggregation-based method for the selective colorimetric detection of chromium(VI) ions (Cr(VI)) in an aqueous solution. In the presence of hydrobromic acid (HBr), bovine serum albumin stable gold nanoparticles (BSA-Au NPs) were gradually dissolved by Cr(VI) in the etching process of gold. The leaching of the BSA-Au NPs results in a rapid and remarkable damping of the surface plasmon resonance (SPR) and hence induces a visible color change. This colorimetric strategy based on the etching process of gold provided a highly sensitive and selective detection method toward Cr(VI). Under optimal conditions, the amount-dependent colorimetric response was linearly correlated with Cr(VI) concentrations ranging from 0.15 μM to 50.0 μM, with a detection limit down to 120 nM measured as 3δ. Moreover, the developed cost-effective probe was successfully applied to real river samples, which demonstrated its potential for field applications.
Prion potentiation after life-long dormancy in mice devoid of PrP

Abstract Prions are neurotropic pathogens composed of misfolded assemblies of the host-encoded prion protein PrPC which replicate by recruitment and conversion of further PrPC by an autocatalytic seeding polymerization process. While it has long been shown that mouse-adapted prions cannot replicate and are rapidly cleared in transgenic PrP0/0 mice invalidated for PrPC, these experiments have not been done with other prions, including from natural resources, and more sensitive methods to detect prion biological activity. Using transgenic mice expressing human PrP to bioassay prion infectivity and RT-QuIC cell-free assay to measure prion seeding activity, we report that prions responsible for the most prevalent form of sporadic Creutzfeldt–Jakob disease in human (MM1-sCJD) can persist indefinitely in the brain of intra-cerebrally inoculated PrP0/0 mice. While low levels of seeding activity were measured by RT-QuIC in the brain of the challenged PrP0/0 mice, the bio-indicator humanized mice succumbed at a high attack rate, suggesting relatively high levels of persistent infectivity. Remarkably, these humanized mice succumbed with delayed kinetics as compared to MM1-sCJD prions directly inoculated at low doses, including the limiting one. Yet, the disease that did occur in the humanized mice on primary and subsequent back-passage from PrP0/0 mice shared the neuropathological and molecular characteristics of MM1-sCJD prions, suggesting no apparent strain evolution during lifelong dormancy in PrP0/0 brain. Thus, MM1-sCJD prions can persist for the entire life in PrP0/0 brain with potential disease potentiation on retrotransmission to susceptible hosts. These findings highlight the capacity of prions to persist and rejuvenate in non-replicative environments, interrogate on the type of prion assemblies at work and alert on the risk of indefinite prion persistence with PrP-lowering therapeutic strategies.
Innovative Medical Technology and the Treatment Decision-Making Process in Multiple Sclerosis: A Focus Group Study to Examine Patient Perspectives

Background Disease-modifying therapies are given to people with multiple sclerosis (MS) to reduce disease progression and relapse frequency. Current modes of administration include oral, injectable and infusion therapy and the treatment decision-making process is complex. A novel mode of treatment administration, an implantable device, is currently under development, yet patient attitudes about the device are unknown. The aim of this study was 1) to understand the treatment decision-making process from the patient perspective and 2) to explore the possible acceptance of an implant to treat MS. Methods Focus groups with people with MS were conducted in the Netherlands. Three topics were addressed: the treatment decision-making process, the current treatment landscape, and attitudes about the implantable device. All focus groups were recorded and transcribed and data were analyzed by raw data coding and creating themes. An online survey was conducted in the Netherlands to quantify interest in an implant. Results Two focus group sessions were held (n=16 participants) and n=93 persons filled out the survey. The main theme that emerged was the constant uncertainty persons with MS face throughout their disease course and during treatment decisions (when to start, stop, continue or switch treatment). Patients were generally positive towards the implant but felt that efficacy and safety should be guaranteed. Conclusion People with MS want some form of control over their disease and treatment course. New medical technologies, such as an implant, may enhance the treatment landscape and with caution we postulate that it may be accepted by patients as a new mode of administration, though further research is needed. For medical technologies to be successful, patients should be engaged early on in the design process.
Characteristic and phylogenetic analyses of chloroplast genome for Syringa komarowii C.K.Schneid. (Oleaceae) from Huoditang, China, an important horticultural plant

Abstract The genus Syringa (Oleaceae) comprises some of the most important cultivated horticultural trees worldwide. Syringa komarowii, is one of these important horticultural plants. We sequenced the complete chloroplast (cp) genomes of S. komarowii (previously identified as var. reflexa) using Illumina Hiseq X Ten platform. The cp genome exhibits a typical quadripartite structure with 158,020 bp in length, which consists of two copies of inverted repeat (IR) regions (25,676 bp) separated by a large single copy (LSC) region (87,628 bp) and a small single copy (SSC) region (19,040 bp). The cp genome of S. komarowii encodes a total of 132 genes, including 88 protein-coding genes, 36 tRNA genes and 8 rRNA genes. A maximum likelihood (ML) phylogenetic analysis resolved that S. komarowii in a clade with S. wolfii and S. yunnanensis. The ML tree also showed Syringa appeared more closely related to Ligustrum than to the other genera in the Oleaceae.