Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlations of organic chemistry study of the 2nd year “Pharmacy” faculty students of of perfume-cosmetic preparations”

In order to analyze the organic chemistry study for 2nd year students of specialty “Technology of perfume-cosmetic preparations” in Zaporizhzhya State Medical University, correlations between preparation time for the theoretical part of the classes, for computer testing and its percentage, the impact of the organic chemistry at school to university mark, and in general for all disciplines attestation, using Pearson and Spearman correlations, Kolmogorov-Smirnov test, were calculated and discussed. It was found, that the best positive impact at the university study was done by organic chemistry education at school. And there was negative correlation between time for tests or theory preparation and computer tests results due to student’s insufficient understanding of the problems.
Energy Efficient Human Activity Recognition using Hybrid Mobile Application Development Approach

Activity recognition is formulated as a classification problem. Human activity recognition(HAR) receives more attentions in recent years, due to many of it’s applications, such as health care, video surveillance and context-aware computing.Human activity are recognized from accelerometer data. Now a days, smartphone are used intensively so the key benefits of using the smartphone accelerometer for human mobility analysis,with or without location determination based upon GPS, WiFi or GSM is that accelerometer is energy-efficient, provides real-time contextual information and has high availability. Using measurements from an accelerometer for human mobility analysis presents its own challenges as all carry smartphones differently and the measurements are body placement dependent.Therefore a novel algorithm is proposed that neutralizes the effect of different smartphone on-body placements and orientations to allow human movements to be more accurately and energy-efficiently identified. We proposed android application AT(Activity Tracker) to collect dataset which runs on android and iOS, record accelerometer data with 40hz frequency like 40 samples per seconds.
AREGU February 47/2

Denda, Mitsuhiro, Toru Tsuchiya, Peter M. Elias, and Kenneth R. Feingold. Stress alters cutaneous permeability barrier homeostasis. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R367–R372, 2000. —Recent studies have shown that psychological stress can influence cutaneous barrier function, suggesting that this form of stress could trigger or aggravate skin disease. In the present study, we demonstrate that transfer of hairless mice to a different cage delays barrier recovery rates. Pretreatment with a phenothiazine sedative, chlorpromazine, before transfer of animals restored the kinetics of barrier recovery toward normal, suggesting that psychological stress is the basis for this alteration in barrier homeostasis. To determine the mechanism linking psychological stress to altered barrier recovery, we first demonstrated that plasma corticosterone levels increase markedly after transfer of animals to new cages and that pretreatment with chlorpromazine blocks this increase. Second, we demonstrated that the systemic administration of corticosterone delays barrier recovery. Finally, we demonstrated that pretreatment with the glucocorticoid receptor antagonist RU-486 blocks the delay in barrier recovery produced by systemic corticosterone, change of cage, or immobilization. These results suggest that psychological stress stimulates increased production of glucocorticoids, which, in turn, adversely affects permeability barrier homeostasis.
Exploring employer attitude towards migrant workers Evidence from managers across Europe

Purpose – Migrants play an essential role in economic and societal outcomes of the host society, both as members of the workforce and as citizens. However, integration and finding employment after migration remain critical issues. The purpose of this paper is to employ an evidence-based quantitative approach to identify migrant workers’ most important qualifications from an employer perspective and to explore factors that influence employer perception of migrants. Design/methodology/approach – This study uses European Social Survey data that contain responses from managers in European countries in 2014 (n1⁄4 2,828) and 2016 (n1⁄4 3,014). Confirmatory factor analysis and structural equation modelling are used to analyse the data. Findings – For managers, migrants’ commitment to the host country’s way of life is more important than their job skills, educational level and language proficiency. The effects of managers’ individual characteristics, including demographics, expectancies and personal values, on their general attitude towards migrants are also quantified. Practical implications – The study’s outcomes can assist migrants to develop the qualifications most valued by employers, and allow policymakers to integrate the organizational perspective into policies and initiatives for integration of migrant labour. Originality/value – Through HR practices, organizations significantly affect migrants’ career outcomes. Yet research on migrant workers from an organizational and managerial perspective is limited. This study identifies migrant workers’ most important qualifications from an employer perspective. It also explores which individual characteristics most influence organizational decision-makers’ perception. Utilizing a crosscultural and longitudinal data set provides a unique opportunity to generate generalizable findings.
GnRH nerve terminals, tanycytes and neurohaemal junction remodeling in the adult median eminence: functional consequences for reproduction and dynamic role of vascular endothelial cells

Although coordinated actions of several areas within the hypothalamus are involved in the secretion of gonadotropin releasing hormone (GnRH), the median eminence of the hypothalamus, where the nerve terminals are located, plays a particularly critical role in the release of GnRH. In adult females, prior to the juxtaposition terminals pericapillary neurohaemal a are reversible. remodeling physiological central release of GnRH and potentiate estrogen-activated GnRH plasticity involves dynamic cell interactions that bring into play astrocytes, vascular endothelial GnRH diffusible gaseous molecules such as endothelial nitric oxide (NO) and paracrine communication processes involving receptors of the erbB tyrosine kinase family, transforming growth factor beta 1 (TGF β 1) and eicosanoids such as prostagladin-E 2 (PGE 2 ). Some of these molecules, because of their ability to diffuse within the median eminence, may also serve as synchronizing cues allowing for the occurrence of functionally meaningful episodes of GnRH secretion by coordinating GnRH release from the GnRH neuroendocrine terminals. response to neuregulin stimulation, a reduced GnRH response to neuregulin treatment in median eminence explants, diminished plasma gonadotrophin levels and delayed onset of
Maximum Likelihood Estimation of the Number of True Null Hypotheses in a Multiple Testing Problem

When there are many hypotheses to be tested, the risk of a false positive finding in the simultaneous inference increases severely. A multiple comparison procedure(MCP), which uses a conservative adjustment in significance level of individual test, is suggested for controlling a familywise error rate. However, the conservativeness becomes substantial when the number of hypotheses is large. If the number of true null hypotheses, m0, is known, it can be used to improve the power for a MCP. This paper proposes two maximum likelihood estimators of m0. One is based on the observed p-value under a mixture model. The estimator is found by the E-M algorithm. The second one is based on the number of rejection at some given level α. The two estimators are compared with the mean-difference method(MD) in a simulation study. The performance of the maximum likelihood estimators depends on the model assumption. When no violation of assumption presents, the maximum likelihood estimators are better than the MD method. The analysis of a real data set from a microarray experiment is given as an illustration.
Versatile 3D Texture Painting using Imaging Geometry

Texture map-based traditional painting systems are often limited by the model’s parameterization from 3D model space to 2D texture space, since finding such a parameterization can be very difficult in practice (sometimes nearly impossible) for models with complex topology or detailed structure distribution. We present a novel data representation, imaging geometry, for 3D appearance modelling and painting. By generating 3D colored points for each triangle contained in a polyhedral surface model, the imaging geometry can support a great variety of painting operations similar to that of the conventional 2D image editor. The key ingredient of our approach is a novel, adaptive data representation for geometry, topology and color of an arbitrary surface, which allows users to treat each triangle as an image. In our experiments, we demonstrate how easily the imaging geometry is applicable to 3D painting for any arbitrary surfaces that includes a model consisting of only a single triangle, multi-part geometry, a non-orientable model, a non-manifold model, an open or a closed model.
Differentiation Capacity of Chondrocytes in Microtissues depends on TGF-β Subtype

A hallmark of a fully functional human knee joint is an intact layer of hyaline cartilage. In case of traumata or osteoarthritis related degeneration, a decline of this cartilage tissue is observed and its superior biomechanical properties are diminished. Therefore, the application of cell based therapeutic methods is in the focus of scientific and clinical interest. During the generation of three-dimensional (3D) cartilage microtissues in vitro, the addition of soluble growth factors like TGF-β1 and TGF-β2 is linked to an improved differentiation potential of the used cells. Starting from these prerequisites, the influence of both growth factors on the redifferentiation potential of isolated chondrocytes during cultivation in a 3D model was investigated. Furthermore, BMP-7 as another candidate to promote chondrogenesis was included as co-stimulator in this study. Therefore, articular chondrocytes were isolated from an unaffected part of condyles of osteoarthritis patients and propagated in vitro as monolayer culture. Microtissues were generated in a three-dimensional culture system without using any scaffold material. During the process of redifferentiation, TGF-β1, TGF-β2 and a combination of TGF-β1 and BMP-7 were added. The degree of differentiation was evaluated by analyzing the expression of proteoglycans and cartilage specific proteins. Propagated cells were able to form three-dimensional cartilage-like tissue constructs. The histochemical and immunohistochemical analysis of cryosections of these microtissues revealed clear differences, with respect to proteoglycan content and the synthesis of hyaline cartilage specific proteins like collagen type II and S100B. According to these results, supplementation with TGF-β2 led to an improved differentiation state of the microtissues, compared to TGF-β1. Moreover, adding BMP-7 simultaneously with TGF-β1 resulted in an even better differentiation state. Based on these findings, a variable inductive potential of TGF-β1 and TGF-β2 on the process of chondrocyte in vitro differentiation is obvious.
High resistance to Sclerotinia sclerotiorum in transgenic soybean plants transformed to express an oxalate decarboxylase gene

Pathogenesis of Sclerotinia sclerotiorum (white mould) has been associated with fungal secretion of oxalic acid (OA). Enzymes capable of degrading OA have been utilized to produce transgenic resistant plants. Transgenic soybean lines containing the decarboxylase gene (oxdc) isolated from a Flammulina sp. were produced by the biolistic process. Molecular analysis revealed successful incorporation of the gene into the plant genome and showed that the oxdc gene was transferred to the progeny plants. Sixteen T2 transgenic events were screened for S. sclerotiorum resistance using a detached leaf assay. The white mould disease progress curve displayed a significant delay in symptom development in all oxdc events compared with the nontransgenic genotype. Area under the disease progress curve (AUDPC) showed reduction in severity ranging from 61% to 96% comparing the oxdc events with the nontransgenic control. One event (OXDC.9.21) presented some plants that did not show any symptoms after 92 h. RT-PCR analysis for detection of oxdc gene transcripts suggested that expression of the oxdc gene is associated with resistance to S. sclerotiorum.
Daryl Tjin-Final Thesis Document

The purpose of this study was to compare the effects of positive versus negative deception on a constant-workload cycling task among untrained individuals. Eight untrained males completed a familiarization trial, then three time-to-exhaustion cycling tasks at a constant load of 66% of their maximal aerobic power output. Participants were blinded from all performance outcomes, except for time elapsed, which was covertly manipulated such that the time displayed in each of the three experimental trials was either: a) 10% faster (positive deception, FAST), b) 10% slower (negative deception, SLOW), or c) normal (control, ACCURATE). Data analysis demonstrated no significant main effect of the deceptive feedback interventions on participant’s time to exhaustion, physiological, neuromuscular, or perceptual measures (p>0.05). To conclude, untrained individuals were unaffected by the influence of deception in a timeto-exhaustion task when time-elapsed is manipulated by either speeding-up, or slowingdown, the clock.
Title : Obligatory role for PKCδ in PIP 2-mediated activation of store-operated TRPC 1 channels in 1 vascular smooth muscle cells

73 In vascular smooth muscle cells (VMSCs), stimulation of Ca-permeable canonical transient receptor 74 potential channel 1 (TRPC1)-based store-operated channels (SOCs) mediate Ca entry pathways 75 which regulate cell contraction, proliferation and migration that are processes associated with vascular 76 disease. It is therefore important to understand how TRPC1-based SOCs are activated. Stimulation of 77 TRPC1-based SOCs requires protein kinase C (PKC) activity, with store-operated PKC-dependent 78 phosphorylation of TRPC1 essential for channel opening by phosphatidylinositol 4,5-bisphosphate 79 (PIP2). Experimental protocols used to activate TRPC1-based SOCs suggest that the PKC isoform 80 involved requires diacylglycerol (DAG) but is Ca-insensitive, which are characteristics of the novel 81 group of PKC isoforms (, , , ). Hence the present study examines if a novel PKC isoform(s) is 82 involved in activating TRPC1-based SOCs in contractile rat mesenteric artery VSMCs. Store-operated 83 whole-cell cation currents were blocked by Pico145, a highly selective and potent TRPC1/4/5 channel 84 blocker and T1E3, a TRPC1 blocking antibody. PKC was expressed in VSMCs, and selective PKC 85 inhibitory peptides and knockdown of PKC expression with morpholinos oligomers inhibited TRPC186 based SOCs. TRPC1 and PKC interactions and phosphorylation of TRPC1 induced by store depletion 87 were both reduced by pharmacological inhibition and PKC knockdown. In addition, store-operated PIP2 88 and TRPC1 interactions were blocked by PKC inhibition, and PKC was required for PIP2-mediated 89 activation of TRPC1 currents. These results identify involvement of PKC in stimulation of TRPC1-based 90 SOCs and highlights that store-operated PKC activity is obligatory for channel opening by PIP2, the 91 likely activating ligand. 92 93 Miguel Martín-Aragón Baudel obtained his PhD in Edinburgh Napier University under the supervision 94 of Mark Darlison and Amy Poole before moving to St George’s University of London to work as a 95 postdoctoral research assistant with Anthony Albert. He is currently working at the University of 96 California, Davis with Manuel Navedo continuing his research interests in ion channel-mediated 97 mechanisms driving vascular contraction and role in diseases such as hypertension and diabetes. 98
Somatic Cell Nuclear Transfer: A Call to Reevaluate Stem Cell Research Policies

Somatic Cell Nuclear Transfer (SCNT), also known as “therapeutic cloning” is a scientific technology in the field of stem cell research. Used in science for decades using animal models, this technique was recently achieved in human cells and has spawned a number of subsequent breakthroughs in the stem cell field. However, due to ethical concerns both in research practice and the outcomes of science, SCNT is prohibited in many legislative contexts in the United States. The recent breakthroughs precipitate the need to reevaluate stem cell research policies in the United States so that this science can continue to advance.
I.3 A Hurricane Lamp in a Dark Night: Exploring Smartphone Use for Acculturation by Refugees

Refugees arriving in Europe face numerous socio-cultural challenges towards being integrated members of their host society. While acculturation strategies and ICT use of refugees have been studied separately, we investigate refugees’ smartphone use for acculturation by conducting qualitative interviews with 30 refugees. We contribute five practices related to acculturation that express refugees’ intercultural exchange within the host society while preserving their original culture: seek information online; communicate with family and friends abroad; meet locals; meet peers and counteract boredom. Tied to these practices, we find the five consequences empowerment, connection to host society, distraction, sense of belonging and connection to origin, which give an account of the various acculturation issues and how refugees use smartphones in support thereof.
Genetic Diversity of Major Histocompatibility Complex (MHC) Class І Genes in Zootoca vivipara

The Major Histocompatibility Complex (MHC), as a family of highly polymorphic genes associated with immune in the genome of the vertebrate, has become an important indicator for assessing the evolutionary potential of wildlife. In order to better protect Zootoca vivipara in the Greater Khingan Range and Lesser Khingan Range, to understand the genetic structure of Z. vivipara, and to explore the mechanism and phylogenetic relationship of the gene polymorphisms, the MHC molecular marker method was used to analyze Z. vivipara population. 47 alleles were obtained from 4 populations. The 4 populations were highly polymorphic, rich in genetic information, and had significant genetic diversity. There were certain inbreeding phenomena. There was a high degree of genetic differentiation among populations, which was caused by genetic drift and natural selection. The sequence undergoes genetic duplication and recombination. The existence of trans-species polymorphism was found in the constructed phylogenetic tree. This study provides a theoretical basis for species protection of Z. vivipara.
Trade-off Study of Heat Sink and Output Filter Volume in a GaN HEMT Based Single Phase Inverter

This paper presents the trade-off study of heat sink and output filter volume of a GaN HEMT based single phase inverter. The selected topology is three-level Active Neutral point Clamped (ANPC) inverter, and the main aim is to explore the benefits of the GaN HEMTs at 600 V blocking class on the system level efficiency, and power density under wide range of operating conditions. The paper starts by introducing the inverter topology, selected PWM scheme and followed by the device features, static and dynamic characterisation and continues with presenting and discussing the results of extensive experimental and analytical characterisation. After this, the impact of GaN HEMTs on inverter volume is discussed in terms of heat sink and output filter volume analysis under different switching frequency and heat sink temperature conditions. The calculation of heat sink volume and single stage LC output filter volume are presented with respect to experimental results of single phase prototype. The findings from static, dynamic characterisation and single phase prototype results clearly show that GaN HEMT has excellent switching performance under wide load current and heat sink temperature conditions. The high performance of the inverter lead to reduction of the combined total volume, including output filter and heat sink volume.
Gender gap in electrical engineering at the University of Belgrade (1923-2010): Analysis of graduates' structure using R

: This paper introduces exploratory analysis of graduates at the University of Belgrade from 1923 to 2010, with the focus on their gender structure. The underrepresentation of women in electrical engineering and computer science is a global issue, and precise data on the local situation is mostly absent from the literature. Preliminary results of objective assessment of gender gap by analysing graduates' gender, graduation age, and module preferences for 87 years are presented. This analysis might be valuable for decision makers in the area of electrical engineering and computer science for designing gender-motivated institutional changes in order to alter male-dominated culture.
The acquisition of scientific evidence between Frye and Daubert. From ad hominem arguments to cross-examination among experts

The Frye and Daubert rulings give us two very different ways to intend the relation between law and science. Through the contributions of Wellman and Walton, we will see how the main method to question the expert’s testimony before a judge deferent to science is to question her personal integrity by using ad hominem arguments. Otherwise, using Alvin Goldman’s novice/expert problem, we will investigate if other manners of argumentative cross-examinations are possible.
Towards Better Understanding of Ancient Civilizations by Storytelling and Gaming

– The new strategies for teaching and learning point to the investigation and the deployment of workable learning methods and scenarios for better understanding of the learning content and engagement learners in more active participation during the perception of knowledge. This paper presents a new learning approach for studying the ancient history and civilization and the Thracian civilization in particular, by storytelling and serious game combination.
Evaluating LTL Formulas for On-Board Unmanned Vehicle Health Monitoring

—The proliferation of unmanned vehicle technologies has drastically increased their use in multiple domains. In the maritime domain, unmanned surface vehicles often pose special requirements for on-board health monitoring and fault mitigation due to long endurance, which increases the likelihood of failures when operating without human oversight. Whereas such vehicles can be equipped with numerous on-board sensors, detecting actual or impending failures is often more complicated than simply thresholding values of a sensor reading. In this paper, we will consider the use of Linear Temporal Logic (LTL) as a means to specify and then evaluate in real-time, the health status of an unmanned surface vehicle. This is accomplished by capturing nominal conditions in LTL formulas and then evaluating these formulas in real-time. The advantage of LTL is that it allows capturing value-based as well as time-based expectations for sensor readings when evaluating system status. We deﬁne a formal language which is an extension of LTL, and a corresponding software evaluation method with bounded performance. An example demonstration of the feasibility of the process is presented.