Miracle-dz/UniFAR-FTUs huggingface dataset:
Use of the Capture-Recapture Method to Estimate the Frequency of Community- and Hospital-Acquired Drug-Induced Acute Kidney Injuries in French Databases

Drug-induced acute kidney injury (AKI) can occur both in primary care (i.e., community-acquired AKI (CA-AKI)) and in hospital settings (i.e., hospital-acquired AKI (HA-AKI)). The reported prevalence of these events varies markedly from one study to another, mainly due to differences in the study design. To estimate the frequency of drug-induced AKIs (both CA-AKIs and HA-AKIs) observed in a French university hospital, we applied the capture-recapture method to 1) the French national pharmacovigilance database (FPVD) and 2) a cohort of hospitalized patients with drug-induced AKIs (documented by analyzing the French national hospital discharge database and the patients’ electronic medical records). Drug-induced AKIs were determined according to the Naranjo algorithm and then categorized as CA-AKIs or HA-AKIs. A total number of 1,557 episodes of AKI were record during the study period, of them, the estimated total number of drug-induced AKIs was 593 [95% confidence interval (CI): 485–702], and the estimated prevalence was 38.1% [95%CI: 35.67–40.50]. The prevalences of HA-AKIs and CA-AKIs were similar (39.4% [36.24–42.54] and 37.4% [33.67–41.21], respectively). Only 6.1% of the drug-induced AKIs were recorded in the FPVD, and the proportions of recorded HA-AKIs and CA-AKI differed markedly (3.0% vs. 10.5%, respectively). One of the most frequently involved drug classes were antibiotics in the HA-AKI subgroup (13.0%) and antineoplastics in the CA-AKI subgroup (8.3%). Application of the capture-recapture method to two incomplete data sources can improve the ability to identify and quantify adverse drug reactions like AKIs. The frequency of drug-induced AKI is relatively high and is probably underestimated. The clinical management of an AKI might depend on where it originated.
Love Is Blind! Exploring the Impact of Brand Love on eWOM in Chinese Hospitality Industry

The rising penetration and value of online information reviews in the hospitality industry have been extensively examined. People are increasingly interacting on interactive online media, prompting firms to create online communities to share electronic word-of-mouth (eWOM) with them and with one another in order to increase brand love. This study seeks to discover what drives consumers to participate in these online brand communities. To examine the research model, an online survey was conducted on 508 consumers who had shared eWOM on social networking sites (SNS). Structural equation modeling (SEM) was employed to test all hypotheses. The findings show that each of the variables has a high impact on brand love, with information quality and virtual interaction having the most significant impact. As a result of brand love, eWOM is significantly increased. Additionally, findings show that the gender gap in the online setting is increasing, as the influence of all characteristics then reward of online brand communities on brand love was adaptable among both male and female associates. Considering the effects of online features (information quality, system quality, virtual interaction, and reward) on online brand communities' impact on brand love and eWOM. Online hotels manager is advised to carefully develop their marketing strategies to retain and attract new consumers. Furthermore, online hotels manager can use the findings from this study to understand the consequences when eWOM is strongly influenced by online brand communities' features. This study is one of the first to illustrate and empirically confirm insight into how online features affect brand lovers in online brand communities. The study adds to the body of knowledge concerning the effectiveness of social media marketing in the Chinese hotel sector.
Emotion Processes Predicting Outbursts and Functional Impact in Misophonia

Misophonia involves a decreased tolerance to certain sounds and is associated with a range of emotions and emotion processes. In addition to the distress caused by misophonia, some individuals report having aggressive outbursts and significant impact on doing things they would like to be able to do. This study aimed to examine whether misophonia-specific cognitive and emotional processes were associated with misophonic outbursts and impact, and whether these relationships could be explained in part by emotion processes not specific to misophonia. A sample of 703 individuals, 315 of whom identified with having misophonia, completed measures of misophonia, depression and anxiety symptoms, anxiety and disgust sensitivity, interoception and beliefs about emotions. Exploratory correlation and regression analyses were used to build mediation models, which were tested using multiple linear regression. Externalising appraisals (blaming others for causing one’s reaction to sounds) were positively associated with misophonic outbursts, and this relationship was partially explained by anxiety symptoms and disgust sensitivity. Sense of emotional threat in misophonia predicted functional impact of misophonia, and this was partially explained by depression symptoms and negative beliefs about emotions. Anxiety sensitivity and interoception were not significant independent predictors of misophonic outbursts or functional impact. These results provide support for the relevance of emotion processes in misophonia and highlight the importance of using multi-dimensional measures of misophonia to improve our understanding of the condition.
Antifungal Activities of Pure and ZnO-Encapsulated Essential Oil of Zataria multiflora on Alternaria solani as the Pathogenic Agent of Tomato Early Blight Disease

The utilization of plant essential oils (EOs) and nanomaterials due to their safety compared with synthetic chemicals has been considered in the management of plant diseases. In this study, the inhibitory effects of Zataria multiflora, Nepeta haussknechtii, Artemisia sieberi, and Citrus aurantifolia EOs in pure and Zinc Oxide (ZnO) nanocapsulated formulations were evaluated on the mycelial growth of Alternaria solani to find a suitable alternative for synthetic chemicals. The crystal structure and morphological properties of the fabricated nanomaterials were assessed via X-ray diffraction (XRD) and scanning electron microscope (SEM) analyses. The textural features of the prepared nanoparticles were investigated with Brunauer–Emmett–Teller (BET) analysis, and the presence of elements in the samples was studied with energy-dispersive X-ray (EDX) technique. The mycelial growth inhibitory (MGI) was performed in the laboratory by mixing with potato dextrose agar (PDA) medium at concentrations of 100, 300, 600, 1,000, 1,500, and 2,000 ppm. Based on the results, major differences were monitored between different concentrations. At the highest studied concentration, the inhibition of Z. multiflora EO was 100%, which was 43.20, 42.37, and 21.19% for N. haussknechtii, A. sieberi, and C. aurantifolia, respectively, and the inhibition of their nanocapsules was 100, 51.32, 55.23, and 26.58%, respectively. In the greenhouse study, Z. multiflora EO and its nanocapsule (ZnO-ZmEO) were compared with the ZnO and chlorothalonil fungicide based on the highest inhibitory of Z. multiflora in vitro. The highest antifungal effect was related to the ZnO-ZmEO by 53.33%. Therefore, the ZnO-ZmEO formulation can be recommended as a biofungicide for managing and controlling tomato early blight disease after further research.
Rapid Model Development for GSFLOW With Python and pyGSFLOW

Following the advancement of high-performance computing and sensor technology and the increased availability of larger climate and land-use data sets, hydrologic models have become more sophisticated. Instead of simple boundary conditions, these data sets are incorporated with the aim of providing more accurate insights into hydrologic processes. Integrated surface-water and groundwater models are developed to represent the most important processes that affect the distribution of water in hydrologic systems. GSFLOW is an integrated hydrologic modeling software that couples surface-water processes from PRMS and groundwater processes from MODFLOW and simulates feedbacks between both components of the hydrologic system. Development of GSFLOW models has previously required multiple tools to separately create surface-water and groundwater input files. The use of these multiple tools, custom workflows, and manual processing complicates reproducibility and confidence in model results. Based on a need for rapid, reproduceable, and robust methods, we present two example problems that showcase the latest updates to pyGSFLOW. The software package, pyGSFLOW, is an end-to-end data processing tool made from open-source Python libraries that enables the user to edit, write input files, run models, and postprocess model output. The first example showcases pyGSFLOW’s capabilities by developing a streamflow network in the Russian River watershed with an area of 3,850 km2 located on the coast of northern California. A second example examines the effects of model discretization on hydrologic prediction for the Sagehen Creek watershed with an area of 28 km2, near Lake Tahoe, California, in the northern Sierra Nevada.
Social Self-Efficacy and Internet Gaming Disorder Among Chinese Undergraduates: The Mediating Role of Alexithymia and the Moderating Role of Empathy

As an increasingly serious social problem, Internet gaming disorder (IGD) of college students may be related to their social self-efficacy. However, the relationship and its internal mechanisms underlying are still unclear. The current study tested the mediating effect of alexithymia in the association between social self-efficacy and IGD, and whether this mediating process was moderated by empathy. Social Self-Efficacy Scale (PSSE), Chinese version of Internet Game Addiction Scale (IGAS-C), Toronto Alexithymia Scale (TAS-20) and Interpersonal Response Scale (IRI-C) were adopted to examine the model on 888 Chinese college students. The results indicated that social self-efficacy was significantly negatively associate with IGD. Mediation analysis illustrated that alexithymia mediated the association between social self-efficacy and IGD. Further, moderated mediation analysis manifested that the mediated effects was stronger for lower level of empathy. The conclusions corroborate and clarify the mechanisms that alexithymia mediated the association between social self-efficacy and IGD, and the mediation effects is moderated via empathy. Besides, these findings provide available references for colleges to conduct educational activities, and at the same time provide scientific suggestions for preventing IGD among undergraduates.
Radiotheranostic Agents in Hematological Malignancies

Radioimmunotherapy (RIT) is a cancer treatment that combines radiation therapy with tumor-directed monoclonal antibodies (Abs). Although RIT had been introduced for the treatment of CD20 positive non-Hodgkin lymphoma decades ago, it never found a broad clinical application. In recent years, researchers have developed theranostic agents based on Ab fragments or small Ab mimetics such as peptides, affibodies or single-chain Abs with improved tumor-targeting capacities. Theranostics combine diagnostic and therapeutic capabilities into a single pharmaceutical agent; this dual application can be easily achieved after conjugation to radionuclides. The past decade has seen a trend to increased specificity, fastened pharmacokinetics, and personalized medicine. In this review, we discuss the different strategies introduced for the noninvasive detection and treatment of hematological malignancies by radiopharmaceuticals. We also discuss the future applications of these radiotheranostic agents.
The Impact of Varying Food Availability on Gene Expression in the Liver: Testing the Match-Mismatch Hypothesis

Background During early phases of life, such as prenatal or early postnatal development and adolescence, an organism's phenotype can be shaped by the environmental conditions it experiences. According to the Match-Mismatch hypothesis (MMH), changes to this environment during later life stages can result in a mismatch between the individual's adaptations and the prevailing environmental conditions. Thus, negative consequences in welfare and health can occur. We aimed to test the MMH in the context of food availability, assuming adolescence as a sensitive period of adaptation. Methods We have previously reported a study of the physiological and behavioral effects of match and mismatch conditions of high (ad libitum) and low (90% of ad libitum intake) food availability from adolescence to early adulthood in female C57BL/6J mice (n = 62). Here, we performed RNA-sequencing of the livers of a subset of these animals (n = 16) to test the effects of match and mismatch feeding conditions on the liver transcriptome. Results In general, we found no effect of the match-mismatch situations. Contrarily, the amount of food available during early adulthood (low vs. high) drove the differences we observed in final body weight and gene expression in the liver, regardless of the amount of food available to the animals during adolescence. Many of the differentially expressed genes and the corresponding biological processes found to be overrepresented overlapped, implicating common changes in various domains. These included metabolism, homeostasis, cellular responses to diverse stimuli, transport of bile acids and other molecules, cell differentiation, major urinary proteins, and immunity and inflammation. Conclusions Our previous and present observations found no support for the MMH in the context of low vs high food availability from adolescence to early adulthood in female C57BL/6J mice. However, even small differences of approximately 10% in food availability during early adulthood resulted in physiological and molecular changes with potential beneficial implications for metabolic diseases.
Novel CNNM2 Mutation Responsible for Autosomal-Dominant Hypomagnesemia With Seizure

CNNM2 is primarily expressed in the brain and distal convoluted tubule (DCT) of the kidney. Mutations in CNNM2 have been reported to cause hypomagnesemia, seizure, and intellectual disability (HSMR) syndrome. However, the clinical and functional effect of CNNM2 mutations remains incompletely understood. We report our clinical encounter with a 1-year-old infant with HSMR features. Mutation screening for this trio family was performed using next-generation sequencing (NGS)-based whole exome sequencing (WES) with the identified mutation verified by Sanger sequencing. We identified a de novo heterozygous mutation c.G1439T (R480L) in the essential cystathionine β-synthase (CBS) domain of CNNM2 encoding CNNM2 (cyclin M2) without any other gene mutations related to hypomagnesemia. The amino acid involved in this missense mutation was conserved in different species. It was also found to be pathogenic based on the different software prediction models and ACGME criteria. In vitro studies revealed a higher expression of the CNNM2-R480L mutant protein compared to that of the wild-type CNNM2. Like the CNNM2-wild type, proper localization of CNNM2-R480L was shown on immunocytochemistry images. The Mg2+ efflux assay in murine DCT (mDCT) cells revealed a significant increase in intracellular Mg2+ green in CNNM2-R480L compared to that in CNNM2-WT. By using a simulation model, we illustrate that the R480L mutation impaired the interaction between CNNM2 and ATP-Mg2+. We propose that this novel R480L mutation in the CNNM2 gene led to impaired binding between Mg2+-ATP and CNNM2 and diminished Mg2+ efflux, manifesting clinically as refractory hypomagnesemia.
A Poroelastic Approach for Modelling Myocardial Oedema in Acute Myocarditis

Myocarditis is a general set of mechanisms that manifest themselves into the inflammation of the heart muscle. In 2017, more than 3 million people were affected by this disease worldwide, causing about 47,000 deaths. Many aspects of the origin of this disease are well known, but several important questions regarding the disease remain open. One of them is why some patients develop a significantly localised inflammation while others develop a much more diffuse inflammation, reaching across large portions of the heart. Furthermore, the specific role of the pathogenic agent that causes inflammation as well as the interaction with the immune system in the progression of the disease are still under discussion. Providing answers to these crucial questions can have an important impact on patient treatment. In this scenario, computational methods can aid specialists to understand better the relationships between pathogens and the immune system and elucidate why some patients develop diffuse myocarditis. This paper alters a recently developed model to study the myocardial oedema formation in acute infectious myocarditis. The model describes the finite deformation regime using partial differential equations to represent tissue displacement, fluid pressure, fluid phase, and the concentrations of pathogens and leukocytes. A sensitivity analysis was performed to understand better the influence of the most relevant model parameters on the disease dynamics. The results showed that the poroelastic model could reproduce local and diffuse myocarditis dynamics in simplified and complex geometrical domains.
High Wind Speed Prevents the Establishment of the Disease Vector Mosquito Aedes albopictus in Its Climatic Niche in Europe

Environmentally suitable habitats of Aedes albopictus (Ae. albopictus) in Europe are identified by several modeling studies. However, it is noticeable that even after decades of invasion process in Europe, the vector mosquito has not yet been established in all its environmentally suitable areas. Natural barriers and human-mediated transport play a role, but the potential of wind speed to explain Ae. albopictus’ absences and its inability to establish in its suitable areas are largely unknown. This study therefore evaluates the potential of wind speed as an explanatory parameter of the non-occurrence of Ae. albopictus. We developed a global ecological niche model with relevant environmental parameters including wind speed and projected it to current climatic conditions in Europe. Differences in average wind speed between areas of occurrence and non-occurrence of Ae. albopictus within its modeled suitable areas were tested for significance. A second global ecological niche model was trained with the same species records and environmental parameters, excluding windspeed parameters. Using multiple linear regression analyses and a test of average marginal effect, the effect of increasing wind speed on the average marginal effect of temperature and precipitation on the projected habitat suitability was estimated. We found that climatically suitable and monitored areas where Ae. albopictus is not established (3.12 ms-1 ± 0.04 SD) have significantly higher wind speed than areas where the species is already established (2.54 ms-1 ± 0.04 SD). Among temperature-related bioclimatic variables, the annual mean temperature was the most important variable contributing to the performance of both global models. Wind speed has a negative effect on the predicted habitat suitability of Ae. albopictus and reduces false-positive rates in model predictions. With increasing wind speed, the average marginal effect of annual mean temperatures decreases but that of the annual precipitation increases. Wind speed should be considered in future modeling efforts aimed at limiting the spread and dispersal of Ae. albopictus and in the implementation of surveillance and early warning systems. Local-scale data collected from fieldwork or laboratory experiments will help improve the state of the art on how wind speed influences the distribution, flight, and dispersal activity of the mosquito.
MicroRNA-21: A Critical Pathogenic Factor of Diabetic Nephropathy

Diabetic nephropathy (DN), one of the most common and intractable microvascular complications of diabetes, is the main cause of terminal renal disease globally. MicroRNA-21 (miR-21) is a kind of miRNA early identified in human circulation and tissues. Mounting studies have demonstrated that miR-21 plays an important role in the development and progression of DN. This collaborative review aimed to present a first attempt to capture the current evidence on the relationship between miR-21 and DN. After a systematic search, 29 relevant studies were included for comprehensively and thoroughly reviewing. All these eligible studies reported that miR-21 was up-regulated in DN, whether in serum or renal tissues of human or animal models. MiR-21 exhibited its pathogenic roles in DN by forming a complex network with targeted genes (e.g. MMP-9, Smad7, TIMP3, Cdk6, FOXO1, IMP3, and MMP2) and the signaling cascades (e.g. Akt/TORC1 signaling axis, TGF-β/NF-κB signaling pathways, TGF-β/SMAD pathway, CADM1/STAT3 signaling, and AGE-RAGE regulatory cascade), which resulted in epithelial-to-mesenchymal transition, extracellular matrix deposition, cytoskeletal remodeling, inflammation, and fibrosis. This review highlights that miR-21 is a pivotal pathogenic factor in the development of DN. It may serve as an attractive potential diagnostic, prognostic, and predictive biomarker for DN in clinical practice after further confirmation of the clinicopathological features and molecular mechanisms of miR-21-mediated DN.
Amelioration of Non-Alcoholic Steatohepatitis by Atractylodes macrocephala Polysaccharide, Chlorogenic Acid, and Geniposide Combination Is Associated With Reducing Endotoxin Gut Leakage

Gut-derived lipopolysaccharide (LPS) leaking through the dysfunctional intestinal barrier contributes to the onset of non-alcoholic steatohepatitis (NASH) by triggering inflammation in the liver. In the present study, a combination consisting of Atractylodes macrocephala polysaccharide (A), chlorogenic acid (C), and geniposide (G) (together, ACG), was shown to ameliorate NASH in mice and reduce hepatic LPS signaling and endotoxemia without decreasing the abundance of identified Gram-negative bacteria through restoring the intestinal tight junctions. Our data indicated that inhibition of LPS gut leakage by the ACG combination contributed to its amelioration of NASH.