Miracle-dz/UniFAR-FTUs huggingface dataset:
Possible Hepatotoxic Effects In Adult Male Albino Rats On Combination Of Ivermectin And Paracetamol Drugs Used In COVID-19 Infection Management Protocol

Introduction: Ivermectin (IVM) and paracetamol (APAP) are among drugs used for treatment of mild and moderate cases of covid-19 infection. Aim: this study aimed to evaluate the potential hepatotoxic effects on combination of both Paracetamol and Ivermectin in adult male albino rats. Methodology: fifty adult male albino rats were divided into control groups (negative and Positive) and IVM and APAP treated group which included thirty rats and subdivided equally into 3 subgroups (III A, B, C). Each rat received orally 3.7mg/kg/day of Ivermectin concomitantly with 370 mg/kg /day of paracetamol (groups III A, B, C were sacrificed after 7 days, 14 days and 28 days respectively). Serum levels of aminotransferases ALT, AST, glutamate dehydrogenase (GLDH) and Hyaluronan (HA), Histopathological examination of liver and immunohistochemical staining for inducible nitric oxide synthase (iNOS) were performed. Results: HA was elevated after 7 days followed by GLDH which increased after 14 days while aminotransferases levels increase only after 28 days of combined IVM and APAP treatment. After 7 days, the histopathological changes in IVM andAPAP treated group was restricted to congestion of central vein with some vaculation in the hepatocytic cytoplasm then aggravated with increased duration of treatment to periportal fibrosis, inflammatory infiltration areas and necrotic foci. Conclusion: Combination of IVM and APAP induced liver injury, detected 7 days after treatment by HA level and accompanied by histopathological changes which became more severe with increasing duration of treatment. IVM and APAP should be used cautiously to avoid possibility of aggravation of liver injury which is believed to be one of covid-19 complications.
Effect of Momentum on the Equity Returns in Kenya: A Review of Literature

: This Paper review literature on momentum and equity returns, it focuses on theoretical review analyzing the main theories anchoring this study, namely Efficient Market Hypothesis (EMH), Behavioral Finance Theories, and Fama and French Theory. The paper further explores the concept of momentum and the concept of equity returns and finally the empirical studies of various studies and identifying the gaps in these studies.
Effect of Weed Control Treatments on some Maize Hybrids and its Associated Weeds

Two field trials were conducted in 2018 and 2019 seasons at Mallawy Agric. Res., Station, El-Minia Governorate, Egypt, to study the effect of fifteen weed control treatments, (Maister power at 750, 500 and 250 cm 3 /fed alone, Maister power at 750, 500 and 250 cm 3 /fed. tank mixed with Divest at 500 cm 3 /fed. Equib at 1125, 750 and 375 cm 3 /fed. alone, Equib at 1125,750 and 375 cm 3 /fed tank mixed with Divest at 500 cm 3 /fed. alone as well as hand hoeing twice and unweeded (check) on weeds, yield and its components of three maize hybrids (SC 168, SC 131 and TC 324). The results indicated that: Maize hybrids exhibited a significant effect on dry weight of grassy and total annual weeds in both seasons. SC 168 surpassed the other tested hybrids in all maize grain yield and its components. Except 100- grain weight. Weed control treatments decreased significantly the dry weight of grassy, broad-leaved and total annual weeds on both seasons, and had a significant effect on maize yield and its component in both seasons. Grassy, broad leaved and total annual weeds differed significantly in first season only. Maize ear diameter, no. rows/ear in both seasons and ear length in the second season only were significantly affected by the interaction between maize hybrids and weed control treatments. Grain yield ardab/fed. were positively and highly significantly correlated with maize yield and its components and negatively and highly significantly correlated with weed characters in both seasons.
Market chain analysis of smallholder coffee producers in debub ari district of south omo zone, SNNPR, Ethiopia

This study mainly aimed at analyzing market chain analysis of coffee in the Debub Ari District. The descriptive and S-C-P model was used. Both primary and secondary data were collected from the study area. The multi-stage sampling technique employed for this study. A total of 194 coffee producer household heads have been randomly selected and interviewed with the help of pre-tested structured questionnaire. The focus group discussion and key informants interviews were conducted to supplement the formal data. The results of S-C-P model indicated that the four firms concentration ratio (CR4) result in the study area was found to be tight oligopolistic for both red and dry coffee which accounts 89.2 and 80.0%, respectively. About 72% of price setting was done by buyers, 27% negotiation and 1% by the producers. There are seven market channels, which have been identified in the study area. The computed marketing margin among different actors and channels indicated that the total gross marketing margin (TGMM) of coffee is high in channel I, II, III whereas the producers marketing margin (GMMp) was highest in channel VII. Therefore, the intervention is needed to improve coffee marketing chain through promoting cooperatives, infrastructural development and timely market information for efficient marketing system in the study area. Int. J. Agril. Res. Innov. Tech. 11(2): 61-68, Dec 2021
Dynamics of Antimicrobial Peptide Encapsulation in Carbon Nanotubes: The Role of Hydroxylation

Introduction Carbon nanotubes (CNTs) have been widely employed as biomolecule carriers, but there is a need for further functionalization to broaden their therapeutic application in aqueous environments. A few reports have unraveled biomolecule–CNT interactions as a measure of response of the nanocarrier to drug-encapsulation dynamics. Methods Herein, the dynamics of encapsulation of the antimicrobial peptide HA-FD-13 (accession code 2L24) into CNTs and hydroxylated CNTs (HCNTs) is discussed. Results The van der Waals (vdW) interaction energy of CNT–peptide and HCNT–peptide complexes decreased, reaching −110.6 and −176.8 kcal.Mol−1, respectively, once encapsulation of the peptide inside the CNTs had been completed within 15 ns. The free energy of the two systems decreased to −43.91 and −69.2 kcal.Mol−1 in the same order. Discussion The peptide was encased in the HCNTs comparatively more rapidly, due to the presence of both electrostatic and vdW interactions between the peptide and HCNTs. However, the peptide remained encapsulated throughout the vdW interaction in both systems. The negative values of the free energy of the two systems showed that the encapsulation process had occurred spontaneously. Of note, the lower free energy in the HCNT system suggested more stable peptide encapsulation.
Efficient plant regeneration and molecular marker-based genetic integrity analysis of Ceropegia lawii Hook: An endemic and endangered herb

The present study aimed to optimize the in vitro direct shoot organogenesis system for propagation, in vitro flowering, and genetic fidelity analysis of micropropagated clones of Ceropegia lawii. The efficiency of various plant growth regulator treatments was evaluated during various regeneration stages. Direct shoot organogenesis cultures were established through stem nodal buds on Murashige and Skoog (MS) medium supplemented by 6-benzylaminopurine (BAP, 0.5 mg/l). Maximum frequency of shoot induction and multiplication (98.5%) with 14 ± 0.5 shoots per explant was attained through the augmentation of BAP (2.0 mg/l) in the MS medium. In vitro-derived shoots were rooted optimum (89.62%) with 6.9 ± 0.1 numbers of roots while transferring to a half-strength MS medium supplied with indole-3-butyric acid (1.5 mg/l). A maximum number of flowers (5.6 ± 0.1) with 91.33% induction frequency were reported when microshoots were transferred to the MS medium formulated with BAP (2.0 mg/l) in combination with sucrose (175 mM). Tissue culture-derived plantlets were adapted best in a mixture of sterile soil, sand, and coco peat (1:2:1) with 88% of survival rate. Inter-simple sequence repeat analysis of regenerated plantlets revealed 99.33% genetic integrity of in vitro regenerated clones when compared with the donor plant. The findings of the present study reveals that the direct shoot organogenesis approach produces a large number of genetically stable plantlets of C. lawii which helps in its conservation and fulfills further industrial necessities.
Effect of Modified Tissue Culture Medium by Nanomaterial on Microtuber Formation of Potato Cultivar Hermes

Nanoparticles (NPs)are involved in multiple areas, i.e, electronics, energy, medicine, life sciences, and agriculture.Induction and accelerating of multiplication and microtuber formation of potato plants (Hermes cultivar) by some treatments i.e. nano-nutrients, medium composition as well as explant type and cultivation orientation were examined in the current study. Datarevealed that bothtreatments of Murashige and Skoog medium (MS) +1.0mg/l benzyl adrnine (BA)+200mg/l thiamine and MS+2.0mg/l BA + 100mg/l thiamine significantly maximized the shoot proliferationcapacity. The highest shoot length was obtained from MS-free BA medium in combination with all thiamine concentrations. The shoot numbers were augmented when calcium (Ca 2+ ) were substituted with 660 or 1320 μg /l Ca 2+ NPs compared with MS (2.77,2.77 and 2.53, respectively), also, shoot length and node numberswas not affected by areplacement which means Ca 2+ ion could be substituted with CaNPs in MS medium without decreasing in potatoshoot proliferation. The promising results of substitution magnesium (Mg 2+ ) with Mg 2+ NPs were recorded, where 185 or 375 μg /l Mg 2+ NPs gave anequal or augmented number of shoots relative tothose obtained on MS medium of Hermes with no significant difference between them, node numbers and shoot length were superior as a result of replacement with Mg 2+ NPs. Shoot tip necroses did not appear with Mg 2+ NPs. Generally, Mg 2+ NPs (375 μg/l) can replace the Mg 2+ ions in MS medium and enhance growth parameters of potato cultivar Hermes. Results came in line with the finding of Javed et al .
Fuzzy Control Method for Synchronous Acquisition of High Resolution Image based on Machine Learning

Aiming at the problem of low baud rate of traditional high-resolution image synchronous acquisition fuzzy control method, a high-resolution image synchronous acquisition fuzzy control method based on machine learning is designed. By detecting the fuzzy edge information of high-resolution image, the fuzzy membership function of synchronous acquisition quantity is proposed, and the gradient amplitude of synchronous acquisition quantity of high-resolution image is calculated. The unsupervised learning algorithm based on machine learning is used to cluster the fuzzy control data, so as to determine the fuzzy space of synchronous acquisition quantity of high-resolution image, and calculate the fuzzy feature similarity, the fuzzy control of synchronous acquisition quantity of high resolution image is realized. Experimental results show that the controlled wave rate in this paper solves the problem of low wave rate in 255.63 bps/h-271.33 bps/h, and significantly improves the control accuracy.
Tissue Engineering in Wound Healing Therapy by Using Chitosan and Stem Cells

Skin wounds are considered as the most critical, and widespread problems due to the high rate of accidents or burn worldwide. Full-thickness skin loss could be chronic or acute wounds, which found difficulty in medical treatment, because of taking a long time in healing. Therefore, exposure to the infection, which delays the healing process and causing disordered healing, ends with distortion or incomplete closure, which might lead to a fatal complication. Thus, the need for skin grafting is a necessary and critical decision although its side effects and rejection possibilities. This review put a spotlight on one of the latest therapeutic techniques in regenerative medicine “tissue engineering”. It is an up-to-dates field in applications of stem cells and cells culture to replace the traditional tissue or organs transplantation techniques. We discussed the skin organ scaffolding as a simple example of tissue engineering applications in accelerating wound healing using stem cells cultured with chitosan scaffold. The latter is characterized by several medical properties especially in skin regeneration, for fabrication of artificial skin, which mimics the natural skin tissue and applying it in chronic or acute wounds
Low-Level Laser Light Effects—Long-Term Effects

Although present laser safety standards are based on an adequate data base for acute viewing situations, they are limited in predicting the type of change in visual function that might be induced from prolonged or repetitive viewing of laser sources. Viewing requirements in holography, laser display systems, and, in general, repeated exposure to low levels of laser radiation require a more complete data base for optimizing the environmental protection of individuals who will be required to work in such environments. In these studies, we have simulated very low-level radiation environments and determined the effects of repetitive prolonged exposure on the visual function of the Rhesus. Our data suggest that prolonged viewing of such sources, even though they are well below present laser safety standards, can produce permanent changes in visual processes that underlie normal human day (photopic) and night (scotopic) vision, although preliminary studies of morphology have shown no morphological correlate. The coherency of laser light is implicated as a significant factor in inducing these effects. It is recommended that individuals required to work in these situations be frequently evaluated for changes in visual function by presently available clinical instruments for assessment of visual function. Further confirmation of these studies will determine the impact of these research findings on present laser safety standards.
Transcriptomics and Metabolomics Reveal the Possible Mechanism by which 1-MCP Regulates the Postharvest Senescence of Zizania latifolia

To understand the mechanism governing the postharvest senescence of Zizania latifolia, and the regulatory mechanism induced by 1-methylcyclopropene (1-MCP) during storage at 25°C, physiobiochemical and conjoint analyses of the transcriptome and metabolome were performed. The results indicated that 1-MCP treatment engendered changes in the expression of genes and metabolites during the postharvest storage of Z. latifolia. The 1-MCP treatment maintained a good visual appearance, preserved the cell structure, and membrane integrity of Z. latifolia by keeping the expression of membranes-related lipolytic enzymes (and related genes) low and the amount of phosphatidylethanolamine high. Compared to the control group, 1-MCP treatment enhanced the activities of antioxidant enzymes, resulting in a decrease of reactive oxygen species (ROS) and malondialdehyde (MDA) contents, and thus inhibition of oxidative damage and loss of membrane integrity. In addition, 1-MCP treatment retarded the senescence of Z. latifolia by down-regulating the expression of ethylene biosynthesis-related genes and promoting up-regulation of brassinosteroid insensitive 1 (BRI1) kinase inhibitor 1, calmodulin (CaM), glutathione reductase, jasmonate amino acid synthase, and mitogen-activated protein kinase (MAPK)-related genes. Moreover, 1-MCP retarded Z. latifolia senescence by inducing the activity of ATP-biosynthesis related genes and metabolites. Our findings should facilitate future research on the postharvest storage of Z. latifolia, and could help delay senescence and prolong the storage time for commercial applications.
Assessment of tumor burden and response to therapy in patients with colorectal cancer using a quantitative ctDNA test for methylated BCAT1/IKZF1

Failure of colorectal cancer (CRC) treatment is due to residual disease, and its timely identification is critical for patient survival. Detecting CRC‐associated mutations in patient circulating cell‐free DNA is confounded by tumor mutation heterogeneity, requiring primary tumor sequencing to identify relevant mutations. In this study, we assessed BCAT1 and IKZF1 methylation levels to quantify circulating tumor DNA (ctDNA) and investigated whether this method can be used to assess tumor burden and efficacy of therapy. In 175 patients with CRC who were ctDNA‐positive pretreatment, ctDNA levels were higher with advancing stage (P < 0.05) and correlated with tumor diameter (r = 0.35, P < 0.001) and volume (r = 0.58, P < 0.01). After completion of treatment (median of 70 days [IQR 49‐109] after surgery, +/− radiotherapy, +/− chemotherapy), ctDNA levels were reduced in 98% (47/48) and were undetectable in 88% (42/48) of patients tested. For those with incomplete adjuvant chemotherapy after surgery, roughly half remained ctDNA‐positive (11/21, 52.4%). The presence of ctDNA after treatment was associated with disease progression (HR 9.7, 95%CI 2.5‐37.6) compared to no ctDNA. Assaying blood for ctDNA methylated in BCAT1/IKZF1 has the potential for identifying residual disease due to treatment failure, informing a potential need for therapy adjustment in advanced disease.
Single Stage Reconfigurable Inverter Cum Converter Grid Linked PV-Battery System

In this thesis a new converter called reconfigurable Solar Converter (RSC) for PV- battery application. Particularly for utility scale PV-battery application is proposed. The basic concept of the converter is to use a single power conversion system to perform different operation modes for solar PV systems with energy storage. The proposed solution requires minimal complexity and modifications to the conventional three-phase solar PV converters for PV-battery systems. The new converter is to use a single-stage three phase grid-tie solar PV converter to perform both dc/ac and dc/dc operations. This converter solution is appealing for PV-battery application, because it minimizes the number of conversion stages, thereby improving efficiency and reducing cost, weight, and its volume. Keywords- Reconfigurable Converter, Energy Storage, Photovoltaic (PV), Solar. I. INTRODUCTION
A Simple Switching Method for A Improved Power Factor Type Single Phase Converter

Recent increase of semiconductor power converter systems brings about harmonic problems. In a single phase power converter, a capacitor-filtered rectifier is used to derive DC voltage from an AC commercial power source. This converter generates harmonic currents and its power factor is very low. In order to reduce harmonic currents and compensate the input power factor, we propose a novel switching method, called the simple partial switching method (SPSM), for a single phase AC to DC converter. A control device of the converter switches once in every half cycle of an AC commercial power source by this SPSM. The switching timing is decided by the input power factor and by the odd order harmonic estimation function of the input current. The estimation function is defined as the harmonics ratio compared with the harmonic currents standard. Experimental results clarify that our SPSM converter reduces harmonic currents and compensates the input power factor.
Suppression Control Method of Vibration for PMSM Utilizing Repetitive Control with Auto-tuning Function and Fourier Transform

The servo motor systems with the PMSM have been widely used for industry applications, home electric appliances, and so on, due to the progress of the power electronics, because of simple structure, easy maintenance, high efficiency, etc. Moreover, because the PMSM can realize the same high performance as DC motor, it is used in the fields where the high speed and high accuracy control is required. However, when the PMSM rotates, the motor frame is vibrated due to the torque ripple of the PMSM and so on. Also, when frequency of the motor frame vibration is especially close to the resonant frequency of the mechanical system, large vibration and acoustic noise are produced.In this paper, authors propose a suppression control method of the vibration for PMSM utilizing feedforward compensation control, and a generation method of compensation signals for the feedforward control by repetitive control with the auto-tuning function, and Fourier transform using a vibration signal acquired by an acceleration sensor attached to the motor frame, considering periodicity. However, the proposed auto-tuning function is not perfect. So a method to cope with this imperfectness is also presented.An experimental system to detect and reduce the vibration is constructed, and the effectiveness of the proposed method is confirmed by experimental results.
Developing the Concept for an Automotive High-Speed SRM Drive with Focus on Acoustics

The automotive industry demands small and cheap drive trains to compensate for battery weight and cost. A fully integrated high-speed SRM drive train could be an answer to this demand. However, high-speed SRM exhibit some characteristic shortcomings such as torque ripple, acoustic noise and partly low efficiency. This paper presents a way to develop a concept which overcomes all these factors. This is done by the right choice of rotational speed, machine configuration and a combination of different control strategies at different speed levels. The most suited tooth configuration was found by comparing several rough machine designs regarding driving-cycle efficiency and acoustic behavior. For efficiency reasons, a three-phase SRM was chosen. The acoustic behavior of the 18/12 configuration turned out to be most suited for a high-speed drive (n max > 20000rpm). The machine was designed rather short but with a large diameter to shift the acoustic problems to the speed range where acoustically oriented control is feasible. The final design shows good driving-cycle efficiency and a maximum surface velocity of 55dB re 1µms −1 . This proves that SRM is a promising alternative for automotive propulsion if the concept is elaborated carefully. This means that the configuration, the speed range and the control strategy have to be coordinated.
A Study on the Impact of Psychological Capital on Organizational Identification

In today’s context human resource is considered as a valuable resource for any business organization as business organizations are operating in a very competitive environment. The study was aimed at investigating the impact of Psychological Capital and its dimensions (Self-efficacy, Optimism, Hope and Resilience) on Organizational Identification of sales persons of C grade Cargills Food City outlets in Colombo District Sri Lanka. There were 116 sales persons in C grade Cargills Food City outlets in Colombo district. The researcher considered entire population for the study as it was considered census method for collecting data. Simple regression analysis and multiple regression were performed to investigate the impact of the variables interested. Pertaining to the previous research findings, the current study also brought evidence to a significant impact of Psychological Capital, Self-efficacy, Hope and Resilience on Organizational Identification. In contrast to the previous research findings, this study highlighted no any impact of optimism on organizational identification. Further, future researchers are advised to do the studies by considering managers or the immediate supervisors’ perspectives about the organizational identification of sales persons, using multiple data collection methods instead of using only self – administrated questionnaires. Index Terms — Hope, Optimism, Organizational Identification, Psychological Capital, Resiliency, Self – efficacy