Miracle-dz/UniFAR-FTUs huggingface dataset:
Bayesian Semiparametric Nonlinear Mixed‐Effects Joint Models for Data with Skewness, Missing Responses, and Measurement Errors in Covariates

Summary It is a common practice to analyze complex longitudinal data using semiparametric nonlinear mixed‐effects (SNLME) models with a normal distribution. Normality assumption of model errors may unrealistically obscure important features of subject variations. To partially explain between‐ and within‐subject variations, covariates are usually introduced in such models, but some covariates may often be measured with substantial errors. Moreover, the responses may be missing and the missingness may be nonignorable. Inferential procedures can be complicated dramatically when data with skewness, missing values, and measurement error are observed. In the literature, there has been considerable interest in accommodating either skewness, incompleteness or covariate measurement error in such models, but there has been relatively little study concerning all three features simultaneously. In this article, our objective is to address the simultaneous impact of skewness, missingness, and covariate measurement error by jointly modeling the response and covariate processes based on a flexible Bayesian SNLME model. The method is illustrated using a real AIDS data set to compare potential models with various scenarios and different distribution specifications.
Three-dimensional structure of Pseudomonas isoamylase at 2.2 A resolution.

The three-dimensional structure of isoamylase from Pseudomonas amyloderamosa, which hydrolyzes alpha-1,6-glucosidic linkages of amylopectin and glycogen, has been determined by X-ray structure analysis. The enzyme has 750 amino acid residues and a molecular mass of 80 kDa, and it can be crystallized from ammonium sulfate solution. The structure was elucidated by the multiple isomorphous replacement method and refined at 2.2 A resolution, resulting in a final R-factor of 0.161 for significant reflections with a root-mean-square deviation from ideality in bond lengths of 0.009 A. The analysis revealed that in the N-terminal region, isoamylase has a novel extra domain that we call domain N, whose three-dimensional structure has not so far been reported. It has a (beta/alpha)8-barrel-type supersecondary structure in the catalytic domain common to the alpha-amylase family enzymes, though the barrel is incomplete, with a deletion of an alpha-helix between the fifth and sixth beta-strands. A long excursed region is present between the third beta-strand and the third alpha-helix of the barrel but, in contrast to the so-called domain B that has been identified in the other enzymes of alpha-amylase family, it cannot be considered to be an independent domain, because this loop forms a globular cluster together with the loop between the fourth beta-strand and the fourth alpha-helix. Isoamylase contains a bound calcium ion, but this is not in the same position as the conserved calcium ion that has been reported in other alpha-amylase family enzymes.
Reputation-Based Incentives for Data Dissemination in Mobile Participatory Sensing Networks

The ever-more-capable smart mobile phone gave birth to a novel sensing paradigm, participatory sensing. In the application environment of mobile participatory sensing networks, mobile equipment is usually weakly connected. Due to uncertainty of connection, mobile nodes sometimes need encounter opportunities to accomplish data communication and transmission. However, the participants’ reluctance would diminish their enthusiasm if there is no incentive mechanism. To address this nontrivial issue, we propose reputation-based incentive schemes to motivate participants to disseminate reliable data in participatory sensing system, named RIDD, while minimizing incentive cost for maintaining sufficient number of reliable participants. When an intended receiver receives the data packet from a participant, the receiver authorizes the participant by an acknowledgment message within an encryption code automatically generated by the data packet, which serves as a proof of successful data delivery. RIDD evaluates participants using reputation degree calculated according to the encryption code, encouraging reliable participants to keep being interested in the participatory service with rewards. We conduct simulations in different scenarios. The results show that RIDD remarkably increases the winning probability of participants who disseminate accurate data and reduces the cost for retaining sufficient number of reliable participants.
Genetic Dissection of Human Stature in a Large Sample of Multiplex Pedigrees

Recently, we reported a whole genome scan on a sample of 630 Caucasian subjects from 53 human pedigrees. Several genomic regions were suggested to be linked to height. In an attempt to confirm the identified genomic regions, as well as to identify new genomic regions linked to height, we conducted a whole genome linkage study on an extended sample of 1,816 subjects from 79 pedigrees, which includes the 53 pedigrees containing the original 630 subjects from our previous whole genome study and an additional 128 new subjects, and 26 further pedigrees containing 1,058 subjects. Several regions achieved suggestive linkage signals, such as 9q22.32 [MLS (multipoint LOD score) = 2.74], 9q34.3 [MLS = 2.66], Xq24 [two‐point LOD score = 2.64 at the marker DXS8067], and 7p14.2 [MLS = 2.05]. The importance of the above regions is supported either by other whole genome studies or by candidate genes within these regions relevant to linear growth or pathogenesis of short stature. In addition, this study has tentatively confirmed the Xq24 region's linkage to height, as this region was also detected in the previous whole genome study. To date, our study has achieved the largest sample size in the field of genetic linkage studies of human height. Together with the findings of other studies, the current study has further delineated the genetic basis of human stature.
Localization of Mesothelin in Epithelial Ovarian Cancer

Mesothelin is a cell surface glycoprotein that is present on normal mesothelial cells and overexpressed in several cancers. On immunohistochemical examination of a limited number of ovarian tumors, increased mesothelin expression has been previously noted. The authors evaluated mesothelin expression in 48 patients with ovarian cancer who were screened for participation in phase 1 studies of a recombinant immunotoxin targeting mesothelin. Eligibility criteria for participation in the studies included mesothelin expression by more than 30% of accessible tumor cells. Sections of formalin-fixed paraffin-embedded tumor specimens were evaluated for mesothelin expression by immunohistochemistry using the anti-mesothelin monoclonal antibody K1. Between September 2000 and January 2003, 48 ovarian tumors were analyzed for mesothelin positivity. Mesothelin positivity was noted in 34 of the 48 cases evaluated (71%). These results show that mesothelin is expressed in most epithelial ovarian cancers and that mesothelin expression in ovarian cancers can be evaluated in archival material. Patients whose tumors express mesothelin could be eligible for participation in clinical trials of novel agents targeting mesothelin.
Design of ternary nanoalloy catalysts: Effect of nanoscale alloying and structural perfection on electrocatalytic enhancement

The ability to tune the atomic-scale structural and chemical ordering in nanoalloy catalysts is essential for achieving the ultimate goal of high activity and stability of catalyst by design. This article demonstrates this ability with a ternary nanoalloy of platinum with vanadium and cobalt for oxygen reduction reaction in fuel cells. The strategy is to enable nanoscale alloying and structural perfection through oxidative–reductive thermochemical treatments. The structural manipulation is shown to produce a significant enhancement in the electrocatalytic activity of the ternary nanoalloy catalysts for oxygen reduction reaction. Mass activities as high as 1 A/mg of Pt have been achieved by this strategy based on direct measurements of the kinetic currents from rotating disk electrode data. Using a synchrotron high-energy X-ray diffraction technique coupled with atomic pair function analysis and X-ray absorption fine structure spectroscopy as well as X-ray photoelectron spectroscopy, the atomic-scale struc.
Thematic Maps for Humanitarian Demining

Hrvatski centar za razminiranje (HCR) je jos 2004. godine pregledao, definirao i oznacio cjelokupnu minski sumnjivu povrsinu (MSP) u Republici Hrvatskoj (RH). Međutim, zbog smanjenja rizika i nedostatka informacija iz dubine MSP-a, njezine granice definirane su u vecim povrsinama nego sto ih zauzima u stvarnosti. Razminiranje je dugotrajan i skup proces, a RH se obvezala da ce do 201 9. godine rijesiti problem mina na svome teritoriju. Takav razvoj situacije dovodi do traženja i pronalaženja rjesenja za ubrzavanje rjesavanja minskog problema u RH (a i u svijetu) redukcijom definiranog MSP-a. Za redukciju vec definiranih MSP-a potrebni su dodatni podaci i informacije iz dubine MSP-a na osnovi kojih ce se revizijom postojeceg MSP-a izvrsiti redukcija. Svi naknadno prikupljeni podaci i informacije, zajedno s poznatim podacima iz minskog informacijskog sustava (MIS) HCR-a, obrađuju se u sustavu za potporu odlucivanja u uvjetima neodređenosti. Tako dobiveni rezultati prikazuju se na razlicitim tematskim kartama koje prikazuju položaje objekta i njihove utjecaje na okolinu u prostoru. Dakle, tematske karte na jednom prikazu daju uvid u teme na osnovi kojih eksperti u humanitarnom razminiranju mogu donositi odluke u tom procesu. Takve tematske karte rezultat su metodologije stvarane unutar projekta Space and Airborne Mined Area Reduction Tools (SMART), a dalje su razvijane: u tehnologijskom projektu Sustav za multisenzorsko zrakoplovno izviđanje i nadzor u izvanrednim situacijama i zastiti okolisa, TP-06/0007-01, Ministarstva znanosti, obrazovanja i sporta RH ; u projektu Deployment of the Advanced Intelligence Advanced Intelligence Decision Support System for Mine Suspected Area Reduction in Bosnia and Herzegovina i autorovoj doktorskoj disertaciji. Ovim radom se uspostavljaju novi nazivi unaprijeđenih i novih tematskih karata koji nedvosmisleno definiraju ono sto prikazuju i olaksavaju citljivost i komunikaciju između proizvođaca i korisnika.
An alternative to the glyoxylate shunt

A cycle remains a cycle only as long as the spokes of the wheel are not stolen. To keep the citric acid cycle going requires anaplerotic reactions such as the glyoxylate shunt to restore the cycle intermediates that are withdrawn for the biosynthesis of cell constituents, e.g. amino acids and haemin precursors. The article by Erb et al. in this issue of Molecular Microbiology documents an alternative path that replenishes four‐carbon intermediates during growth on acetate in the absence of the glyoxylate shunt. The reaction sequence forms malate and succinyl‐CoA from three acetyl‐CoA, one CO2 and one HCO3 in a linear pathway. This new pathway was discovered in phototrophic anoxygenic bacteria and in few aerobic bacteria, but it is probably widespread among many metabolic groups of bacteria.
THE ESTIMATION OF THE SUBCUTANEOUS TISSUE PRESSURE BY A DIRECT METHOD.

Subcutaneous tissue pressure may be defined as the pressure with which the tissue structures resist any change in their anatomical relationships. Since the pioneer work of Landerer (1) in the estimation of tissue pressure, little has been done to evaluate the importance of this factor in normal and pathological physiologic processes. Recent studies (2, 3, 4) have shown no uniformity in normal values. The present investigation is an attempt to throw additional light upon these problems and establish standards for our technic.
The global cost of nonoptimal blood pressure

Objective Suboptimal blood pressure including established nonoptimal blood pressure has been shown to have significant economic consequences in developed countries. However, no exhaustive study has been done to evaluate its potential costs, globally. We, therefore, set out to estimate the global economic cost of nonoptimal blood pressure. Methods Estimates for healthcare costs attributed to suboptimal blood pressure for those over the age of 30 were made for all the World Bank regions. Annual and 10-year estimates using Markov models were made for the cost of treating nonoptimal blood pressure and its main sequelae: stroke and myocardial infarction. Results Suboptimal blood pressure cost US$370 000 000 000 globally in 2001. This represents about 10% of the world's overall healthcare expenditures. In the Eastern Europe and Central Asia region, high blood pressure consumed 25% of all health expenditures. Over a 10-year period, elevated blood pressure may cost nearly $1 000 000 000 000 globally in health spending, if current blood pressure levels persist. Indirect costs could be as high as $3 600 000 000 000 annually. Conclusion Suboptimal blood pressure is responsible for a large and an increasing economic and health burden in developing countries. Although the majority of the current absolute expenditure occurs in the high-income countries, an ever-increasing proportion of the cost is going to be carried by developing countries.
Genomic tools in acute myeloid leukemia: From the bench to the bedside

Since its use in the initial characterization of an acute myeloid leukemia (AML) genome, next‐generation sequencing (NGS) has continued to molecularly refine the disease. Here, the authors review the spectrum of NGS applications that have subsequently delineated the prognostic significance and biologic consequences of these mutations. Furthermore, the role of this technology in providing a high‐resolution glimpse of AML clonal heterogeneity, which may inform future choice of targeted therapy, is discussed. Although obstacles remain in applying these techniques clinically, they have already had an impact on patient care. Cancer 2014;120:1134–1144. © 2014 American Cancer Society.
Mechanical Design and Development of the Touch Hand II Prosthetic Hand

R & D Journal of the South African Institution of Mechanical Engineering 2016, 32, 23-34 http://www.saimeche. org.za (open access) © SAIMechE All rights reserved. 23 The Touch Hand II is a desktop 3D printed prosthetic hand that has been developed to improve on the first design iteration, in order to reach the goal of providing transradial amputees with a low-cost alternative prosthetic hand, in comparison to commercial options. The powered grip strength, closing/opening times, mass, power usage, aesthetics, structural integrity, and cost have all been improved on through this research. The new design is compared to five other low-cost hands and two commercial hands. This comparison shows that the new design has seven characteristics that are similar to or outperform the commercial products. The same can only be said for at most four characteristics of the other low-cost hands. This paper focuses on the mechanical design of the major hand components, although it is also shown how the custom circuit board fits in the palm, and an overview of the programmed control system is described, with possible future additions of amputee feedback and command input.
Thermal behaviour of a three-phase induction motor fed by a fault tolerant voltage source inverter

This paper presents the results of an investigation regarding the thermal behaviour of a three-phase induction motor, when supplied by a reconfigured three-phase voltage source inverter with fault tolerant capabilities. For this purpose, a fault tolerant operating strategy based on the connection of the faulty inverter leg to the DC link middle point was considered. The experimental obtained results show that, as far as the motor thermal characteristics are concerned, it is not necessary to reinforce the motor insulation properties since it is already prepared for such an operation
Individualized kV Selection and Tube Current Reduction in Excretory Phase Computed Tomography Urography: Potential for Radiation Dose Reduction and the Contribution of Iterative Reconstruction to Image Quality

Objective The objective of this study was to analyze radiation dose reduction and image quality by combining automated kV selection, tube current reduction, and iterative reconstruction. Methods This was a retrospective analysis of the excretory phase of 55 patients with 2 computed tomography urography examinations: automated kV selection with tube current reduction (“low-dose protocol”: with filtered back projection vs iterative reconstruction) and routine dose examinations. Image quality was analyzed blindly and in side-by-side analyses, in addition to quantitative measurements. Results Low-dose protocol median dose change was −40% (−10.7 to +12.9 mGy); 100 kV was autoselected in 44 (80%) of 55 patients (body mass index range, 19–36 kg/m2) with mean dose reduction of 42.5%. Whereas up to 19% of low-dose images with filtered back projection were inferior by blinded review (P < 0.001), low-dose iterative reconstruction images were not rated inferior (P = 1.0). Conclusions The combination of iterative reconstruction, automated kV selection, and tube current reduction results in radiation dose reduction with preserved image quality and diagnostic confidence.
Analytical Design Algorithm of Planar Inductor Layout in CMOS Technology

A layout design algorithm for a variable-width inductor is proposed to minimize metal resistance. For a given chip area, the proposed algorithm can rapidly design metal widths of each coil in a planar inductor due to the analytical form. Two on-chip inductors with identical chip areas and inductance are fabricated to verify the proposed method in foundry 90-nm CMOS technology. Measurement results demonstrate that the improvement of metal resistance in the proposed device is approximately 19%. The results of this paper provide an effective algorithm to design a high-Q inductor for RFIC applications.
Customised Order Fulfillment in a Machine Tool Supply Network

The research presented in the paper attempts to help globalised organisations to identify alternative supply network configurations and management strategies, to respond to different customised order fulfillment demand scenarios within existing cost and time restrictions. A case study of a machine tool manufacturer is presented. The company has a global multi-plant network and imperative requirements for introducing flexibility in a market demanding products with a high degree of customisation. Machine tools have a total production lead time longer than the market time. Therefore, the machine manufacturing process has to start before customers orders arrive. When an order arrives, a machine that is in process must be allocated to it. Some relevant information is collected and reviewed to carry out this allocation. The path across the manufacturing network that the allocated machine is going to follow is generated, the point where customisation will be executed to reconfigure the machine to the specific order requirements is identified and the delivery time is communicated to the customer. The research shows how this information is managed to make the allocation and how a simulation tool is used as a decisional support system to identify better network design alternatives for the location of new plants, warehouses, or logistics platforms, under mass customisation scenarios.
Molecular Cloning, Expression, and Functional Significance of a Cytochrome P450 Highly Expressed in Rat Heart Myocytes*

A cDNA encoding a P450 monooxygenase was amplified from reverse transcribed rat heart and liver total RNA by polymerase chain reaction using primers based on the 5′- and 3′-end sequences of two rat pseudogenes, CYP2J3P1 andCYP2J3P2. Sequence analysis revealed that this 1,778-base pair cDNA contained an open reading frame and encoded a new 502 amino acid protein designated CYP2J3. Based on the deduced amino acid sequence, CYP2J3 was approximately 70% homologous to both human CYP2J2 and rabbit CYP2J1. Recombinant CYP2J3 protein was co-expressed with NADPH-cytochrome P450 oxidoreductase in Sf9 insect cells using a baculovirus expression system. Microsomal fractions of CYP2J3/NADPH-cytochrome P450 oxidoreductase-transfected cells metabolized arachidonic acid to 14,15-, 11,12-, and 8,9-epoxyeicosatrienoic acids and 19-hydroxyeicosatetraenoic acid as the principal reaction products (catalytic turnover, 0.2 nmol of product/nmol of cytochrome P450/min at 37 °C). Immunoblotting of microsomal fractions prepared from rat tissues using a polyclonal antibody raised against recombinant CYP2J2 that cross-reacted with CYP2J3 but not with other known rat P450s demonstrated abundant expression of CYP2J3 protein in heart and liver. Immunohistochemical staining of formalin-fixed paraffin-embedded rat heart tissue sections using the anti-CYP2J2 IgG and avidin-biotin-peroxidase detection localized expression of CYP2J3 primarily to atrial and ventricular myocytes. In an isolated-perfused rat heart model, 20 min of global ischemia followed by 40 min of reflow resulted in recovery of only 44 ± 6% of base-line contractile function. The addition of 5 μm 11,12-epoxyeicosatrienoic acid to the perfusate prior to global ischemia resulted in a significant 1.6-fold improvement in recovery of cardiac contractility (69 ± 5% of base line,p = 0.01 versus vehicle alone). Importantly, neither 14,15-epoxyeicosatrienoic acid nor 19-hydroxyeicosatetraenoic acid significantly improved functional recovery following global ischemia, demonstrating the specificity of the biological effect for the 11,12-epoxyeicosatrienoic acid regioisomer. Based on these data, we conclude that (a) CYP2J3 is one of the predominant enzymes responsible for the oxidation of endogenous arachidonic acid pools in rat heart myocytes and (b) 11,12-epoxyeicosatrienoic acid may play an important functional role in the response of the heart to ischemia.
Spin-mechanical device for detection and control of spin current by nanomechanical torque

We propose a spin-mechanical device to control and detect spin currents by mechanical torque. Our hybrid nanoelectromechanical device, which contains a nanowire with a ferromagnetic-nonmagnetic interface, is designed to measure or induce spin-polarized currents. Since spin carries angular momentum, a spin-flip or spin-transfer process involves a change in angular momentum and hence, a torque, which enables mechanical measurement of spin flips. Conversely, an applied torque can result in spin polarization and spin current.
A simple decoupling control method for isolated three-port bidirectional converter in low-voltage DC microgrids

Multi-port isolated H-bridge converter has the features of high voltage conversion ratio, bidirectional power flow and high-power capacity, which is suitable to be integrated into DC microgrids. This paper uses three-port isolated H-bridge converters as the interfacing converters in power generation units which comprise distributed generation (DG) and energy storage (ES) in DC microgrid. The topology and phase-shifting control of this three-port converter are introduced at first. After this, the equivalent model is presented, and on this basis, a decoupling control method is proposed to eliminate the coupled power flow of each port. As a result, under the decoupling equation and the closed-loop control, the system transient performance is improved. Simulation studies are implemented to demonstrate the validity of the proposed control method.