Miracle-dz/UniFAR-FTUs huggingface dataset:
Sex, military occupation and rank are associated with risk of anterior cruciate ligament injury in tactical-athletes

Introduction Anterior cruciate ligament (ACL) injury is common within the US military and represents a significant loss to readiness. Since recent changes to operational tempo, there has not been an analysis of ACL injury risk. The aim of this retrospective cohort study was to evaluate military occupation, sex, rank and branch of service on ACL injury risk in the US military from 2006 to 2018. Methods The Defense Medical Epidemiology Database was queried for the number of US tactical athletes with International Classification of Diseases diagnosis codes 717.83 (old disruption of ACL), 844.2 (sprain of knee cruciate ligament), M23.61 (other spontaneous disruption of ACL) and S83.51 (sprain of ACL of knee) on their initial encounter. Relative risk and χ2 statistics were calculated to assess sex and military occupation effects on ACL injury. A multivariable negative binomial regression model evaluated changes in ACL injury incidence with respect to sex, branch of service and rank. Results The study period displayed a significant decrease in the ACL injury rate at 0.18 cases per 1000 person-years or relative decrease of 4.08% each year (p<0.001) after averaging over the main and interactive effects of sex, rank and branch of service. The interaction effect of time with sex indicated a steeper decline in the incidence in men as compared with women. The risk of ACL injury by sex was modified by rank. The incidence among military personnel varied by occupation. Conclusion Despite the decline among tactical athletes over time, rates of ACL injury remain much higher than the general US population. Sex, rank, branch of service and military occupation were found to be risk factors for ACL injury. It is critical for policy makers to understand the salient risk factors for ACL injury to guide proactive measures to prevent injury.
Insights for the Development of a Functional Fish Product: Drivers and Barriers, Acceptance, and Communication of Health Benefits

ABSTRACT This study aims to explore consumer acceptance of a new functional fish burger using a qualitative approach based on four focus group discussions conducted in selected major Italian cities. Results show that the development of functional fish products may bypass fish consumption barriers, combining convenience and health benefits delivered by functional ingredients. The acceptance of new functional fish products seems to be influenced positively by the enrichment of functional ingredients naturally present in fish, particularly omega-3 fatty acids. Consumer acceptance of this new product is also influenced by the use of different nutritional and health claims. Implications for marketers and policy makers and insights for further research are discussed in the conclusions.
Effects of the Close Collaboration With Parents Intervention on the Quality of Family-Centered Care in NICUs

Background: Systematic training for the neonatal staff to support parents' active involvement is lacking. There is little information about the effectiveness of educational interventions. Purpose: To evaluate the effects of an educational intervention to neonatal staff on the quality of family-centered care from the perspectives of parents and nurses. Methods: A quasi-experimental before and after study was carried out in 5 Finnish neonatal units in 2014-2018. Data were collected using the DigiFCC-tools with a 7-point Likert scale. Thirty-one fathers and 53 mothers were recruited before the intervention and 21 fathers and 61 mothers after the intervention. They answered 1 question every evening until their infants' discharge. Each nurse answered 1 corresponding question after every shift, during the same period before and after the intervention. Before the intervention 3239 responses and after the intervention 3092 responses were received from nurses. Results: The fathers' total score and the score indicating “Shared decision making” were higher after the intervention than before the intervention. The mothers' total score did not differ between the 2 time periods. The nurses' total score was higher after the intervention than before the intervention. Of the individual items, higher scores were found for “Active listening,” “Parents' trust in the nurse,” and “Emotional support. ” Implications for Practice: Developing the staff's negotiating and active listening skills facilitates better support for parents during infants' intensive care. Implications for Research: Family-centered care interventions such as Close Collaboration with Parents should be studied in randomized controlled trials, also including child outcomes.
Evaluation of Gait and Functional Stability in Preoperative Cervical Spondylotic Myelopathy Patients

Prospective data of biomechanical feedback mechanisms of 56 subjects undergoing decompressive surgery were collected. Preoperative CSM patients showed significant alterations in spatiotemporal gait parameters and postural stability compared with controls. Likewise, angular momentum analysis demonstrates that these patients have globally increased body excursion to maintain dynamic balance. Study Design. Prospective cohort study. Objective. The aim of this study was to 1) determine postural stability and spatiotemporal gait parameters and 2) characterize dynamic stability and variances in angular momentum (AM) of preoperative cervical spondylotic myelopathy (CSM) patients compared with healthy controls. Summary of Background Data. CSM is the most common cause of spinal cord dysfunction in the world and can lead to significant functional deficits including proprioception and gait disturbances. Biomechanical feedback mechanisms compensating for these deficits, specifically AM regulation, have remained largely unexplored. Methods. Fifty-six subjects: 32 preoperative Nurick grade 2 or 3 CSM patients and 24 controls were included. Standing balance trials were performed on a single force plate, while walking trials were conducted at self-selected pace over a 15 m runway and a series of five force plates. All trials were recorded with three-dimensional motion analysis cameras and gait modeling software was utilized to calculate stability, spatiotemporal gait parameters, and joint kinematics. Results. Tilted ellipse area, a measure of center of pressure variance and postural stability, was significantly greater among CSM patients (847.54 ± 764.33 mm2vs. 258.18 ± 103.35 mm2, P < 0.001). These patients had two times as much variance medial-lateral (72.12 ± 51.83 mm vs. 29.15 ± 14.95 mm, P = 0.001) and over three times as much anterior-posterior (42.25 ± 55.01 mm vs. 9.17 ± 4.83 mm, P = 0.001) compared with controls. Spatiotemporal parameters indicated that the CSM patients tending to have slower, shorter, and wider gait compared with controls, while spending greater amount of time in double support. Compensatory AM among CSM patients was significantly increased in all three anatomic planes, where whole-body AM was approximately double that of controls (0.057 ± 0.034 vs. 0.023 ± 0.006), P < 0.001). Conclusion. Preoperative CSM patients showed significant alterations in spatiotemporal gait parameters and postural stability compared with controls, consistent with prior literature. Likewise, angular momentum analysis demonstrates that these patients have globally increased body excursion to maintain dynamic balance. Level of Evidence: 3
Will borealization of Arctic tundra herbivore communities be driven by climate warming or vegetation change?

Poleward shifts in species distributions are expected and frequently observed with a warming climate. In Arctic ecosystems, the strong warming trends are associated with increasing greenness and shrubification. Vertebrate herbivores have the potential to limit greening and shrub advance and expansion on the tundra, posing the question of whether changes in herbivore communities could partly mediate the impacts of climate warming on Arctic tundra. Therefore, future changes in the herbivore community in the Arctic tundra will depend on whether the community tracks the changing climates directly (i.e. occurs in response to temperature) or indirectly, in response to vegetation changes (which can be modified by trophic interactions). In this study, we used biogeographic and remotely sensed data to quantify spatial variation in vertebrate herbivore communities across the boreal forest and Arctic tundra biomes. We then tested whether present‐day herbivore community structure is determined primarily by temperature or vegetation. We demonstrate that vertebrate herbivore communities are significantly more diverse in the boreal forest than in the Arctic tundra in terms of species richness, phylogenetic diversity and functional diversity. A clear shift in community structure was observed at the biome boundary, with stronger northward declines in diversity in the Arctic tundra. Interestingly, important functional traits characterizing the role of herbivores in limiting tundra vegetation change, such as body mass and woody plant feeding, did not show threshold changes across the biome boundary. Temperature was a more important determinant of herbivore community structure across these biomes than vegetation productivity or woody plant cover. Thus, our study does not support the premise that herbivore‐driven limitation of Arctic tundra shrubification or greening would limit herbivore community change in the tundra. Instead, borealization of tundra herbivore communities is likely to result from the direct effect of climate warming.
N-(Acyloxy)phthalimides as Redox-Active Esters in Cross-Coupling Reactions

Recent years have witnessed a resurgence of novel, efficient and practical protocols for radical-mediated cross-coupling reactions involving N-(acyloxy)phthalimides (NHPI esters) as redox-active esters. After the initial discovery of the redox-active properties of NHPI esters, exciting examples of SET-based cross-coupling reactions under thermal or photolytic conditions leading to diverse C–X (X=C, B, Si, Se, S) bonds have been published. The operational simplicity and broad applicability exhibited in redox-active NHPI ester-based cross-couplings bode well for their widespread adoption. The review presented herein covers all the recent developments in the field of redox-active ester (RAE)-based cross-couplings since the initial discovery. Depending on the conditions employed the reactions have been categorized into photoinduced and non-photoinduced cross-couplings with representative examples and insightful mechanistic discussions.
Factors associated with paravertebral muscle cross-sectional area in patients with chronic low back pain

Background This study was performed to reveal the relationships between the cross-sectional areas (CSAs) of the paraspinal muscles and the severity of low back pain (LBP), including the level of disability. Methods This single-center cross-sectional study was conducted on 164 patients with chronic LBP. The effects of demographic characteristics, posture, level of physical activity, disc herniation type, and sarcopenia risk on the CSAs of paraspinal muscles were evaluated along with the relationship between the CSAs and severity of pain and disability in all patients. The CSAs of paraspinal muscles were evaluated using the software program Image J 1.53. Results A negative significant correlation was found between age and the paraspinal muscle’s CSA (P < 0.05), whereas a positive correlation was present between the level of physical activity and the CSA of the paraspinal muscle at the L2-3 and L3-4 levels. The CSAs of paraspinal muscles in patients with sarcopenia risk was significantly lower than those in patients without sarcopenia risk (P < 0.05). The CSAs of paraspinal muscles at the L2-3 and L3-4 levels in obese patients were significantly higher than those in overweight patients (P = 0.028, P = 0.026, respectively). There was no relationship between the CSAs of paraspinal muscles and pain intensity or disability. Conclusions Although this study did not find a relationship between paraspinal CSAs and pain or disability, treatment regimens for preventing paraspinal muscles from atrophy may aid pain physicians in relieving pain, restoring function, and preventing recurrence in patients with chronic LBP.
STRATISFIMAL LAYOUT: A modular optimization model for laying out layered node-link network visualizations

Node-link visualizations are a familiar and powerful tool for displaying the relationships in a network. The readability of these visualizations highly depends on the spatial layout used for the nodes. In this paper, we focus on computing layered layouts, in which nodes are aligned on a set of parallel axes to better expose hierarchical or sequential relationships. Heuristic-based layouts are widely used as they scale well to larger networks and usually create readable, albeit sub-optimal, visualizations. We instead use a layout optimization model that prioritizes optimality – as compared to scalability – because an optimal solution not only represents the best attainable result, but can also serve as a baseline to evaluate the effectiveness of layout heuristics. We take an important step towards powerful and flexible network visualization by proposing STRATISFIMAL LAYOUT, a modular integer-linear-programming formulation that can consider several important readability criteria simultaneously – crossing reduction, edge bendiness, and nested and multi-layer groups. The layout can be adapted to diverse use cases through its modularity. Individual features can be enabled and customized depending on the application. We provide open-source and documented implementations of the layout, both for web-based and desktop visualizations. As a proof-of-concept, we apply it to the problem of visualizing complicated SQL queries, which have features that we believe cannot be addressed by existing layout optimization models. We also include a benchmark network generator and the results of an empirical evaluation to assess the performance trade-offs of our design choices. A full version of this paper with all appendices, data, and source code is available at osf.io/qdyt9 with live examples at https://visdunneright.github. io/stratisfimal/.
Luminescent sol-gel-derived micro and nanoparticles

This paper presents a short review of the results obtained by the authors in the field of the sol–gel-derived glass nanoparticles activated with lanthanides ions. The attention is focused on the systems that are particularly interesting for photonic structures and bioapplications. We discuss how the sol–gel technology allows to prepare different kind of active nanoparticles and how is possible to use them in specific applications. Some examples showing fabrication techniques of spherical micro- and nanoparticles are given, including preparation of rare-earth-doped silica and silica-calcia glass. The proper structures are mentioned to tailor the optical and spectroscopic properties of microresonators. Glass-ceramics systems are also reminded where nanocrystalline particles are derived. Fabrication and spectroscopic assessment of rare earth doped HfO2 and SnO2 nanoparticles are presented as well. Finally, it is discussed how bioactive properties of SiO2– CaO nanoparticles can be used in medicine, for example in tracking using their luminescent properties.
In‐hospital respiratory viral infections for patients with established BPD in the SARS‐CoV‐2 era

Our objective was to test the hypothesis that in‐hospital respiratory viral infections (RVI) would be significantly lower in a cohort of patients with established bronchopulmonary dysplasia (BPD) exposed to a severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection prevention protocol when compared to historical controls.
CD47 antibody blockade suppresses microglia-dependent phagocytosis and monocyte transition to macrophages, impairing recovery in EAE

Experimental autoimmune encephalomyelitis (EAE) is a well-characterized animal model of multiple sclerosis. During the early phase of EAE, infiltrating monocytes and monocyte-derived macrophages contribute to T cell recruitment, especially CD4+ T cells, into the CNS, resulting in neuronal demyelination; however, in later stages, they promote remyelination and recovery by removal of myelin debris by phagocytosis. Signal regulatory protein α and CD47 are abundantly expressed in the CNS, and deletion of either molecule is protective in myelin oligodendrocyte glycoprotein–induced EAE because of failed effector T cell expansion and trafficking. Here we report that treatment with the function blocking CD47 Ab Miap410 substantially reduced the infiltration of pathogenic immune cells but impaired recovery from paresis. The underlying mechanism was by blocking the emergence of CD11chiMHCIIhi microglia at peak disease that expressed receptors for phagocytosis, scavenging, and lipid catabolism, which mediated clearance of myelin debris and the transition of monocytes to macrophages in the CNS. In the recovery phase of EAE, Miap410 Ab–treated mice had worsening paresis with sustained inflammation and limited remyelination as compared with control Ab–treated mice. In summary, Ab blockade of CD47 impaired resolution of CNS inflammation, thus worsening EAE.
Heart rate variability and interoceptive accuracy predict impaired decision-making in Gambling Disorder

Abstract Background and aims Gambling Disorder (GD) entails maladaptive patterns of decision-making. Neurophysiological research points out the effect of parasympathetic arousal, including phasic changes in heart rate variability (HRV), and interoceptive accuracy (IA, i.e., the ability to track changes in bodily signals), on decision-making. Nevertheless, scarce evidence is available on their role in GD. This is the first study exploring the impact in GD of respiratory sinus arrhythmia (RSA), an index of HRV, and IA on decision-making, as measured by the Iowa Gambling Task (IGT). Methods Twenty-two patients experiencing problems with slot-machines or video lottery terminals gambling and 22 gender- and age-matched healthy controls (HC) were recruited. A resting ECG was performed before and after the completion of the IGT. IA was assessed throughout the heartbeat detection task. We conducted a MANCOVA to detect the presence of significant differences between groups in RSA reactivity and IA. A linear regression model was adopted to test the effect of factors of interest on IGT scores. Results Patients with GD displayed significantly decreased RSA reactivity (P = 0.002) and IA (P = 0.024) compared to HCs, even after controlling for affective symptoms, age, smoking status, and BMI. According to the linear regression model, cardiac vagal reactivity and IA significantly predict decision-making impairments on the IGT (P = 0.008; P = 0.019). Discussion and conclusions Although the exact pathways linking HRV and IA to impaired decision-making in GD remain to be identified, a broader exploration relying upon an embodiment-informed framework may contribute to shed further light on the clinical phenomenology of the disorder.
Aflatoxin B1 and sterigmatocystin: method development and occurrence in tea

ABSTRACT Tea is one of the most popular beverage in the world and may be contaminated by fungi and mycotoxins during processing. To analyse aflatoxin B1 (AFB1) and sterigmatocystin (STC) in three types of tea, a simple, fast, sensitive and reliable method of these two myxotoxins was developed. Recoveries obtained ranged from 95.9% to 118.0% and the RSDs were between 0.3% and 11.2%. The range of LODs was 0.2–0.45 µg/kg for AFB1 and 0.04–0.12 µg/kg for STC. The range of LOQs was 0.67–1.73 µg/kg for AFB1 and 0.13–0.40 µg/kg for STC. The optimised procedure was applied to analyse 126 tea samples randomly collected from different markets in China. AFB1 was not detected, but STC was determined in 17 samples with concentrations ranging from 0.13 to 4.48 µg/kg. The detection rate of STC was 5%, 8.9% and 33.3% in black tea, green tea and Oolong tea, respectively.
Bio-chemical markers of chronic, non-infectious disease in the human tear film

ABSTRACT The tear film is a thin, moist layer covering the ocular surface and is laden with proteins, peptides, lipids, mucins, electrolytes and cellular debris which function to maintain the healthy status of the ocular surface. In many cases of ocular or systemic disease, the integrity of this layer is changed and/or the balance of its constituents is disturbed. Since tears are easy and quick to collect and can be stored for long periods, they have the potential to be a valuable source of information relevant to many disease states. The purpose of this review is to collate information on the known biomarkers of systemic disease that have been identified in tears. The range of conditions covered includes diabetes mellitus, diabetic retinopathy, diabetic peripheral neuropathy, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, migraine, systemic sclerosis, cystic fibrosis, thyroid disorders and cancer.
Termite soil as a potential low-cost adsorbent for the removal of methylene blue and malachite green dyes

The adsorption of methylene blue (MB) and malachite green (MG) from aqueous solution using a termite soil has been studied by batch adsorption technique. The adsorption experiments were carried out under different conditions of initial concentration (5–100 mg/L). The equilibrium data were fitted to Langmuir and Freundlich isotherms and the equilibrium adsorption was best described by the Langmuir isotherm model with maximum monolayer adsorption capacities found to be 338.98 and 327.21 mg/g at 305 K, respectively. Three kinetic models, pseudo-first-order, pseudo-second-order and intraparticle diffusion were employed to describe the adsorption mechanism. The experimental results showed that the pseudo-second-order equation is the best model that describes the adsorption behaviour with the coefficient of correlation R2 ≥0.99. Fourier transform infra red (FTIR) spectroscopy, X-ray diffraction (XRD), Scanning electron microscopy (SEM), Tunnelling electron microscopy (TEM) studies are evident that the termite soil has an effective adsorbent material.The results suggested that termite soil has high potential to be used as effective adsorbent for MB removal.