Miracle-dz/UniFAR-FTUs huggingface dataset:
Representation Learning of Entities and Documents from Knowledge Base Descriptions

In this paper, we describe TextEnt, a neural network model that learns distributed representations of entities and documents directly from a knowledge base (KB). Given a document in a KB consisting of words and entity annotations, we train our model to predict the entity that the document describes and map the document and its target entity close to each other in a continuous vector space. Our model is trained using a large number of documents extracted from Wikipedia. The performance of the proposed model is evaluated using two tasks, namely fine-grained entity typing and multiclass text classification. The results demonstrate that our model achieves state-of-the-art performance on both tasks. The code and the trained representations are made available online for further academic research.
Influence of the Chemical Form of Antimony on Soil Microbial Community Structure and Arsenite Oxidation Activity

In the present study, the influence of the co-contamination with various chemical forms of antimony (Sb) with arsenite (As[III]) on soil microbial communities was investigated. The oxidation of As(III) to As(V) was monitored in soil columns amended with As(III) and three different chemical forms of Sb: antimony potassium tartrate (Sb[III]-tar), antimony(III) oxide (Sb2O3), and potassium antimonate (Sb[V]). Soil microbial communities were examined qualitatively and quantitatively using 16S rDNA- and arsenite oxidase gene (aioA)-targeted analyses. Microbial As(III) oxidation was detected in all soil columns and 90–100% of added As(III) (200 μmol L−1) was oxidized to As(V) in 9 d, except in the Sb(III)-tar co-amendments that only oxidized 30%. 16S rDNA- and aioA-targeted analyses showed that the presence of different Sb chemical forms significantly affected the selection of distinct As(III)-oxidizing bacterial populations. Most of the 16S rRNA genes detected in soil columns belonged to Betaproteobacteria and Gammaproteobacteria, and some sequences were closely related to those of known As(III) oxidizers. Co-amendments with Sb(III)-tar and high concentrations of Sb2O3 significantly increased the ratios of aioA-possessing bacterial populations, indicating the enrichment of As(III) oxidizers resistant to As and Sb toxicity. Under Sb co-amendment conditions, there was no correlation between aioA gene abundance and the rates of As(III) oxidation. Collectively, these results demonstrated that the presence of different Sb chemical forms imposed a strong selective pressure on the soil bacterial community and, thus, the co-existing metalloid is an important factor affecting the redox transformation of arsenic in natural environments.
Not every fulminant lymphocytic myocarditis fully recovers.

: Fulminant myocarditis is a distinct entity within the acute forms of myocarditis characterized by a rapidly progressive clinical course. Lymphocytic forms have been historically reported to generally resolve spontaneously with early appropriate aggressive supportive care alone. We describe the case of a 28-year-old man with lymphocytic fulminant myocarditis presenting with out-of-hospital cardiac arrest, treated with veno-arterial extracorporeal membrane oxygenation, progressed to end stage cardiac failure requiring heart transplantation. In line with recent evidence, we highlight the need for prolonged supportive treatment and the eventual persistent long-term ventricular dysfunction in patients with fulminant myocarditis.
Design of Tri-Band Microstrip Patch Antenna

Compared with conventional microwave antennas, microstrip antennas are with small size, light weight, simple to manufacture, low cost, and ease of integration, etc. therefore, microstrip antenna has a wide range of applications in communication and radar fields. The antenna have been analyzed and designed by using the ‘High Frequency Structure Simulator’ (HFSS) software. The designed antenna in this paper can achieve triple band performance to simultaneously cover the 1.90GHz, 2.45GHz and 3.20GHz frequency with return loss of -26.0dB, -24.0dB and -18.0dB respectively. The designed antenna application systems include global system for mobile communication (GSM), the wireless area network (WLAN) in the 2.4-GHz (2.4-2.485 GHz) band, global positioning system (GPS), Worldwide Interoperability for Microwave Access (Wi-MAX) as well as global navigation satellite systems (GNSS). Other important areas of applications include biomedical, missiles and much more.
Actin cytoskeleton assembly regulates collagen production via TGF‐β type II receptor in human skin fibroblasts

The dermal compartment of skin is primarily composed of collagen‐rich extracellular matrix (ECM), which is produced by dermal fibroblasts. In Young skin, fibroblasts attach to the ECM through integrins. During ageing, fragmentation of the dermal ECM limits fibroblast attachment. This reduced attachment is associated with decreased collagen production, a major cause of skin thinning and fragility, in the elderly. Fibroblast attachment promotes assembly of the cellular actin cytoskeleton, which generates mechanical forces needed for structural support. The mechanism(s) linking reduced assembly of the actin cytoskeleton to decreased collagen production remains unclear. Here, we report that disassembly of the actin cytoskeleton results in impairment of TGF‐β pathway, which controls collagen production, in dermal fibroblasts. Cytoskeleton disassembly rapidly down‐regulates TGF‐β type II receptor (TβRII) levels. This down‐regulation leads to reduced activation of downstream effectors Smad2/Smad3 and CCN2, resulting in decreased collagen production. These responses are fully reversible; restoration of actin cytoskeleton assembly up‐regulates TβRII, Smad2/Smad3, CCN2 and collagen expression. Finally, actin cytoskeleton‐dependent reduction of TβRII is mediated by induction of microRNA 21, a potent inhibitor of TβRII protein expression. Our findings reveal a novel mechanism that links actin cytoskeleton assembly and collagen expression in dermal fibroblasts. This mechanism likely contributes to loss of TβRII and collagen production, which are observed in aged human skin.
Scalable Natural Gradient Langevin Dynamics in Practice

Stochastic Gradient Langevin Dynamics (SGLD) is a sampling scheme for Bayesian modeling adapted to large datasets and models. SGLD relies on the injection of Gaussian Noise at each step of a Stochastic Gradient Descent (SGD) update. In this scheme, every component in the noise vector is independent and has the same scale, whereas the parameters we seek to estimate exhibit strong variations in scale and significant correlation structures, leading to poor convergence and mixing times. We compare different preconditioning approaches to the normalization of the noise vector and benchmark these approaches on the following criteria: 1) mixing times of the multivariate parameter vector, 2) regularizing effect on small dataset where it is easy to overfit, 3) covariate shift detection and 4) resistance to adversarial examples.
Nuclear Genetic Analysis of the Red Fox Across its Trans-Pacific Range

The red fox (Vulpes vulpes) occurs on multiple continents in diverse habitats, making it an informative system for evolutionary genomic research. However, its phylogeography remains unclear. Previously, mitochondrial DNA and small numbers of nuclear loci provided discordant views. Both markers indicated deep divergence (~ 0.5 million years [MY]) between Eurasian and southern North American populations but differed in the apparent continental affinity of Alaskan red foxes, implying some degree of gene exchange during secondary contact (~0.1 MY). We assayed >173000 nuclear genomic sites in 52 red foxes, along with 2 Rueppell's foxes (Vulpes rueppellii) and a gray wolf (Canis lupus) using the Illumina CanineHD BeadChip. We obtained 5107 single nucleotide polymorphisms (SNPs) in the foxes. Consistent with the Afro-Eurasian origins of red foxes, genetic diversity was higher in Eurasian than North American samples. Phylogenetic trees indicated that Alaskan and southern North American red foxes formed a monophyletic group nested within the Eurasian clade. However, admixture models suggested Alaskan red foxes contained up to 40% Eurasian ancestry. We hypothesize that North American red foxes either hybridized with Eurasian foxes in Beringia at the start of the last glaciation or merged with a Beringian population after the last glaciation. Future work is needed to test between these scenarios and assess speciation.
A Zebrafish Embryo as an Animal Model for the Treatment of Hyperpigmentation in Cosmetic Dermatology Medicine

For years, clinical studies involving human volunteers and several known pre-clinical in vivo models (i.e., mice, guinea pigs) have demonstrated their reliability in evaluating the effectiveness of a number of depigmenting agents. Although these models have great advantages, they also suffer from several drawbacks, especially involving ethical issues regarding experimentation. At present, a new depigmenting model using zebrafish has been proposed and demonstrated. The application of this model for screening and studying the depigmenting activity of many bioactive compounds has been given great attention in genetics, medicinal chemistry and even the cosmetic industry. Depigmenting studies using this model have been recognized as noteworthy approaches to investigating the antimelanogenic activity of bioactive compounds in vivo. This article details the current knowledge of zebrafish pigmentation and its reliability as a model for the screening and development of depigmenting agents. Several methods to quantify the antimelanogenic activity of bioactive compounds in this model, such as phenotype-based screening, melanin content, tyrosinase inhibitory activity, other related proteins and transcription genes, are reviewed. Depigmenting activity of several bioactive compounds which have been reported towards this model are compared in terms of their molecular structure and possible mode of actions. This includes patented materials with regard to the application of zebrafish as a depigmenting model, in order to give an insight of its intellectual value. At the end of this article, some limitations are highlighted and several recommendations are suggested for improvement of future studies.
Matching Startup Founders to Investors: a Tool and a Study

The process of matching startup founders with venture capital investors is a necessary first step for many modern technology companies, yet there have been few attempts to study the characteristics of the two parties and their interactions. Surprisingly little has been shown quantitatively about the process, and many of the common assumptions are based on anecdotal evidence. In this thesis, we aim to learn more about the matching component of the startup fundraising process. We begin with a tool (VCWiz), created from the current set of best-practices to help inexperienced founders navigate the founder-investor matching process. The goal of this tool is to increase efficiency and equitability, while collecting data to inform further studies. We use this data, combined with public data on venture investments in the USA, to draw conclusions about the characteristics of venture financing rounds. Finally, we explore the communication data contributed to the tool by founders who are actively fundraising, and use it to learn which social attributes are most beneficial for individuals to possess when soliciting investments.
Electric Properties Tomography (EPT) of the Liver in a Single Breathhold Using SSFP

MR-based Electric Properties Tomography (EPT) provides a noninvasivemeans to assess electric tissue properties, such as conductivity and permittivity, and provides a framework for an accurate determination of local SAR. Furthermore, it may provide a diagnostic parameterin oncology and cardiology. Recently, simplified EPT reconstructionmethods based on the pure image phase information were introduced.In these studies, spin echo (SE) sequences were employed due to their low susceptibility to B0 variations, or fast field echo (FFE) sequences in concert with B0 mapping were performed. However, these scans are prohibitively long for applications which require breath-holding. In the present study, we have employed a fast balanced SSFP sequence, which has similar properties as SE in terms of B0-independendphase accuracy, but provides increased imaging speed and allows forabdominal imaging in a single breathhold. Phantom experiments and first in vivo conductivity scans in the liver of healthy adults are shown.
Regional Differences in Efficacy, Safety, and Biomarkers for Second-Line Axitinib in Patients with Advanced Hepatocellular Carcinoma: From a Randomized Phase II Study

Background: An unmet need exists for treatment of patients with advanced hepatocellular carcinoma (HCC) who progress on or are intolerant to sorafenib. A global randomized phase II trial (ClinicalTrial.gov No. NCT01210495) of axitinib, a vascular endothelial growth factor receptor 1-3 inhibitor, in combination with best supportive care (BSC) did not prolong overall survival (OS) over placebo/BSC, but showed improved progression-free survival in some patients. Subgroup analyses were conducted to identify potential predictive/prognostic factors. Methods: The data from this phase II study were analyzed for the efficacy and safety of axitinib/BSC in patients from Asia versus non-Asia versus Asian subgroups (Japan, Korea, or mainland China/Hong Kong/Taiwan) and predictive/prognostic values of baseline microRNAs and serum soluble proteins, using the Cox proportional hazards model. Results: Of 202 patients, 78 were from non-Asia and 124 from Asia (37 Japanese, 36 Korean, and 51 Chinese). No significant differences in OS were found between axitinib/BSC and placebo/BSC in non-Asians, Asians, or Asian subgroups. However, in an exploratory analysis, axitinib/BSC showed favorable OS in Asians, especially Japanese, when patients intolerant to prior antiangiogenic therapy were excluded from the data set. Axitinib/BSC was well tolerated by non-Asians and Asians alike. The presence of 4 circulating microRNAs, including miR-5684 and miR-1224-5p, or a level lower than or equal to the median protein level of stromal cell-derived factor 1 at baseline was significantly associated with longer OS in axitinib/BSC-treated Asians or non-Asians. Conclusions: Axitinib/BSC did not prolong survival over placebo/BSC in non-Asians, Asians, or Asian subgroups, but favorable OS with axitinib/BSC was observed in a subset of Japanese patients. A patient population that excludes sorafenib-intolerant patients might potentially be more suitable for clinical trials of new agents in advanced HCC. Since these results are very preliminary, further investigation is warranted. The potential predictive/prognostic value of several baseline microRNAs and soluble proteins identified in this study would require validation in prospective studies on a large cohort of patients.
Diffusion distinguishes between axonal loss and demyelination in brain white matter

axonal geometry used for the MC simulations showing the intraaxonal space (red), extra-axonal space (blue) and myelin (green). Neurodegeneration is modeled by increasing axonal loss (left to right), and/or demyelination (top to bottom). (b) The simulated tortuosity as a function of the AWF. The full lines represent contours for constant axon number and varying gratio, while the dashed lines represent constant g-ratio and varying axon number. (c) The average values and standard error ellipses for the tortuosity and AWF (corrected for age) in two clinical applications (left: MS, right AD) overlaid on Fig. 1(b). (a)
Item Analysis using a Derived Science Achievement Test Data

Item analysis is useful in both the development, evaluation of assessments tools and in computing standardized measures of student performance. In item analysis, item statistics (difficulty, discrimination) for each item or question provide a means of assessing the quality of the test items. This study demonstrates the use of the classical item analysis to evaluate the quality of multiple choices Chemistry test items used in Kano state qualifying examination in July 2014. Forty items Chemistry test administered to students at the end of their senior secondary school two (SSII) was subjected to the classical analysis using sample of 530 students, the Statistical Packages for the Social Sciences, version 20 (SPSS 20V) was used to determine the discrimination and difficulty indices of the items and the classification of the items according to their item characteristics. Findings revealed that, out of the 40 items in the test, 12 (30%) items failed to meet the set criteria of item quality and are therefore needs to be revise or improve for further administration. 28 items based on the established standards has been considered as ‘good’ items. Similarly the results indicate a significant positive correlation between item difficulty and item discrimination indices. It is recommended that, the teacher made Chemistry achievement tests use to examine sciences secondary school students’ achievement should be made to pass through all the processes of standardization and validation by conducting psychometric analysis to improve their quality.
Survey of Different Clustering Algorithms in Data Mining

: Clustering is the process of collecting similar data in to a group. Clustering is very important in various fields such as machine learning, pattern recognition and statistics. Clustering is a unsupervised learning technique. In this paper following clustering techniques have been discussed- K-Medoid, K-Means Clustering, DBSCAN clustering, IDBSCAN Hierarchical Clustering, OPTICS.
An assessment of physiotherapist’s delivery of behaviour change techniques within the SOLAS feasibility trial

OBJECTIVES To investigate physiotherapist's (PTs) fidelity to 31 protocol-listed behaviour change techniques (BCTs) during a group-based self-management intervention. This study also explored the PTs delivery of these BCTs beyond the present or absent dichotomy, using a third variable, partial delivery (i.e., attempted). DESIGN Assessment of the intervention arm of the Self-management of Osteoarthritis and Low back pain through Activity and Skills (SOLAS) cluster, randomized controlled feasibility trial, using quantitative methods. METHODS Eight PTs delivered six SOLAS classes each, of which 50% were audio-recorded and transcribed. Transcripts were coded by two raters using the Behaviour Change Technique Taxonomy v1 and an intervention-specific manual and assessed for the delivery (i.e., full, partial, or absent) of the 31 BCTs and their target behaviours. Fidelity was calculated as fully delivered BCTs listed as a percentage of those due to take place within each class. RESULTS Physiotherapists delivered a mean 20.5 BCTs per class (68.3%; range = 64.9-72.4%). Of these, 17 BCTs were fully delivered in each class representing moderate fidelity to the protocol (56.8%; range = 53.5-59.3%). A further 3.5 BCTs per class (11.5%; range = 8.7-14.8%) were partially delivered. BCTs associated with 'goals and planning' were often poorly delivered. CONCLUSIONS Delivering the SOLAS intervention BCTs with high fidelity was not feasible. The assessment of partial delivery of BCTs provided greater insight into the techniques that should be removed from the protocol or that may require further training. Complex interventions should consider a list of 'core' or mandatory BCTs alongside 'optional' BCTs, depending on the target behaviour, and the needs of individual participants. Statement of contribution What is already known on this subject? BCTs are the smallest active components of behavioural interventions, yet typically their effectiveness is determined through meta-analyses. Attempted delivery of BCTs is often unaccounted for yet may provide valuable insight into difficulty with delivery. There is a need to investigate BCT implementation beyond simple presence/absence to identify protocol refinements or required BCT training. What does this study add? BCT delivery was assessed in greater depth than previous research, including partial delivery. Highlights the need for appropriate training in BCTs that are difficult to deliver, particularly those associated with 'goals and planning' Highlights the need for intervention-specific criteria as to what constitutes 'high', 'moderate', and 'low' fidelity.
Comparison of psychosocial and medical characteristics of patients with dementia and their primary informal caregivers between inpatient and day clinic treatment

Background Caregiver burden is one of the most common reasons for hospitalization of patients with dementia. However, changes of location are not recommended for patients with dementia and associated with negative outcomes for patients with dementia. As there is yet a lack of outpatient treatment options, this study explores psychiatric day clinic treatment as option for patients with dementia by comparing characteristics of voluntarily treated patients with dementia and their respective informal caregivers between an inpatient and day clinic setting. Methods A total of 92 patients with dementia (56 inpatient, 36 day clinic) and their informal caregiver provided information on psychosocial and clinical characteristics (Mini-Mental-Status-Test, Neuropsychiatric Inventory, Bayer Activities of Daily Living, Barthel Index, Geriatric Depression Scale-30, Beck’s Depression Inventory-II, caregiver burden, Short Form Health Survey-36) at the beginning of treatment and at follow-up (n = 48 patient caregiver dyads) six months after discharge. Results Patients with dementia did not differ in disease severity, neuropsychiatric symptoms, and depression depending on treatment setting. However, the higher the Bayer activities of daily living score, the more likely treatment in day clinic was. Caregivers from patients with dementia in the inpatient setting were younger and reported more financial burden, whereas caregivers from patients with dementia in the day clinic reported lower physical health and more burden due to practical caring responsibilities. Longitudinal data indicated no differences in characteristics of patients with dementia and caregivers depending on treatment setting, despite caregivers from patients in the day clinic reporting more depressive symptoms after six months. Conclusion Day clinic treatment for voluntarily treated patients with dementia might be an alternative to inpatient settings. Patients with dementia do not substantially differ depending on treatment setting, rather characteristics of the caregivers were associated with placement in inpatient or day clinic setting. The needs of caregivers deserve special attention when considering treatment for patients with dementia.
Generating Image Sequence from Description with LSTM Conditional GAN

Generating images from word descriptions is a challenging task. Generative adversarial networks(GANs) are shown to be able to generate realistic images of real-life objects. In this paper, we propose a new neural network architecture of LSTM Conditional Generative Adversarial Networks to generate images of real-life objects. Our proposed model is trained on the Oxford-102 Flowers and Caltech-UCSD Birds-200-2011 datasets. We demonstrate that our proposed model produces the better results surpassing other state-of-art approaches.