Miracle-dz/UniFAR-FTUs huggingface dataset:
Management and Control of Operating Regimes of Cross-Flow Water Turbines

This paper deals with a generation system based on cross-flow water turbines (CFWTs) operating in a river stream. It is equipped with a permanent-magnet synchronous generator and can feed a power grid or an insulated load through a back-to-back power electronics converter. This paper concerns the control of these two operating regimes with focus on the manner of achieving a soft switching between them, in order to ensure the balance between the generated and the provided power and to alleviate transients. The control laws and the switching sequences have been experimentally validated on a real-time CFWT simulator equipped with the same type of generator and power electronics converter. This paper aims at offering a synthetic vision of how the CFWT-based generation system should be controlled across the main operating regimes in order to preserve its continuity of service.
Numerical Analysis of Ridged-Circular Nanoaperture for Near-Field Optical Disk

A ridged-circular nanoaperture is investigated through three-dimensional (finite-difference time-domain) FDTD method. The motion equations of free electrons are inserted to analyze a metallic material. The electromagnetic field distributions of optical near-field around the aperture are investigated. The phase change disk illuminated by a near-field optical light through a ridged-circular nanoaperture is also analyzed. The far-field scattering patterns from the phase change disk and the crosstalk characteristics between plural marks are studied.
An Isolated DC/DC Converter Using High-Frequency Unregulated  $LLC$ Resonant Converter for Fuel Cell Applications

This paper suggests an isolated dc/dc converter using an unregulated LLC converter for fuel cell applications. The LLC converter operates as an isolated voltage amplifier with a constant voltage gain, and a nonisolated converter installed in the input stage regulates the output voltage under a wide variation of fuel cell stack voltage. By separating the functions, the unregulated LLC converter can be operated at an optimal switching condition, and the high-frequency operation of 300 kHz can be accomplished without introducing an excessive switching loss. The prototype converter with a 1-kW design (Vin = 24 ~ 48 V/Vo = 400 V) shows an efficiency of above 90.2% under a 24-V input and full load conditions.
Virulent Bacteriophages Can Target O104:H4 Enteroaggregative Escherichia coli in the Mouse Intestine

ABSTRACT In vivo bacteriophage targeting of enteroaggregative Escherichia coli (EAEC) was assessed using a mouse intestinal model of colonization with the O104:H4 55989Str strain and a cocktail of three virulent bacteriophages. The colonization model was shown to mimic asymptomatic intestinal carriage found in humans. The addition of the cocktail to drinking water for 24 h strongly decreased ileal and weakly decreased fecal 55989Str concentrations in a dose-dependent manner. These decreases in ileal and fecal bacterial concentrations were only transient, since 55989Str concentrations returned to their original levels 3 days later. These transient decreases were independent of the mouse microbiota, as similar results were obtained with axenic mice. We studied the infectivity of each bacteriophage in the ileal and fecal environments and found that 55989Str bacteria in the mouse ileum were permissive to all three bacteriophages, whereas those in the feces were permissive to only one bacteriophage. Our results provide the first demonstration that bacterial permissivity to infection with virulent bacteriophages is not uniform throughout the gut; this highlights the need for a detailed characterization of the interactions between bacteria and bacteriophages in vivo for the further development of phage therapy targeting intestinal pathogens found in the gut of asymptomatic human carriers.
New Multilevel Converters Based on Stacked Commutation Cells With Shared Power Devices

In this paper, a new three-level (3L) converter is presented. It is called 3L Vienna neutral-point-clamped (3L-VNPC) converter and consists of two stacked high-frequency (HF) commutation cells working with a shared power device. The HF cells are connected to a single-phase switched bridge controlled at low frequency. The 3L-VNPC topology is extended to 3L active VNPC (3L-AVNPC) concept, which is generalized for five levels (5L) and N odd voltage levels (N L). The proposed multilevel converters can be seen as two cascaded voltage stages. The high-voltage stage is specific to the single-phase switched bridge, while the low-voltage (LV) stage corresponds to the stacked HF cells with shared power devices. The new concept AVNPC is a useful and suitable solution for medium-voltage applications, where small modulation index (M) is as crucial as large M. The analyses of the new converters are verified by simulations both for 3L and for 5L topologies, and their features are generalized for NL. Experimental results for single-phase 3L-AVNPC converter on an LV test bench are also provided to validate the proper operation of the new concept.
RESULTS FROM EQAS FOR ANTIBIOTICS SHOW THE NEED TO IMPROVE THE QUALITY OF THE PHARMACOKINETIC INTERPRETATION DURING MONITORING.

Abstract A mandatory external quality assessment scheme for Therapeutic Drug Monitoring is operational in Belgium. This quality scheme aims to provide an assessment of the state of the art of Therapeutic Drug Monitoring as practiced in the Belgian laboratories. The external quality assessment scheme’ main objective is to evaluate laboratories on their ability to approach their peer group’s median value. In addition to the analytical result, an interpretation for some parameters such as aminoglycosides is frequently asked by using case reports. Even when analytical performance is good, many laboratories encounter problems interpreting the results especially when the intervals of blood collections are uncommon. Results illustrate the added value of the use of dedicated software to support pharmacokinetic interpretation.
Spin echo transverse relaxation and atrophy in multiple sclerosis deep gray matter: A two-year longitudinal study

Background: Deep gray matter (DGM) is affected in relapsing–remitting multiple sclerosis (RRMS) and may be studied using short-term longitudinal MRI. Objective: To investigate two-year changes in spin-echo transverse relaxation rate (R2) and atrophy in DGM, and its relationship with disease severity in RRMS patients. Methods: Twenty six RRMS patients and 26 matched controls were imaged at 4.7 T. Multiecho spin-echo R2 maps and atrophy measurements were obtained in DGM at baseline and two-year follow-up. Differences between MRI measures and correlations to disease severity were examined. Results: After two years, mean R2 values in the globus pallidus and pulvinar increased by ~4% (p<0.001) in patients and <1.7% in controls. Two-year changes in R2 showed significant correlation to disease severity in the globus pallidus, pulvinar, substantia nigra, and thalamus. Multiple regression of the two-year R2 difference using these four DGM structures as variables, yielded high correlation with disease severity (r=0.83, p<0.001). Two-year changes in volume and R2 showed significant correlation only for the globus pallidus in multiple sclerosis (MS) (p<0.05). Conclusions: Two-year difference R2 measurements in DGM correlate to disease severity in MS. R2 mapping and atrophy measurements over two years can be used to identify changes in DGM in MS.
Multiple Health Risk Behaviors in Adolescents: An Examination of Youth Risk Behavior Survey Data

Background: Chronic disease risk factors tend to cooccur. Purpose: This study examined the cooccurrence of 8 negative health behaviors in a representative sample of urban adolescents to inform educational interventions. Methods: The prevalence, cooccurrence, and clustering of suicide attempt, lifetime history of sexual activity, tobacco use, cell phone use while driving, risky weight loss, daily soda consumption, sedentary behavior, and extreme video game use were examined among 1354 high school students. Results: Fifty-three percent of the sample were female and 61% were black. Most (80.3%) engaged in 1 to 3 risk behaviors, 10.4% reported none, and 0.5% had engaged in 6 to 8. Ever having sex was the most common cooccurring risk behavior and 4 distinct clusters of risk behaviors emerged: cluster 1 (N = 325) ever having sex; cluster 2 (N = 236): frequent soda drinking; cluster 3 (N = 402): sedentary + extreme video game use; cluster 4 (N = 391): current smoking + attempted suicide + cell phone use while driving + risky weight loss. Discussion: Adoption of multiple risk behaviors is common in youth. A history of sexual activity may be a risk behavior that is shared across different clusters of risk behaviors. Translation to Health Education Practice: Programming designed to address multiple risk behaviors concurrently in youth may be warranted.
TD-1792 versus Vancomycin for Treatment of Complicated Skin and Skin Structure Infections

ABSTRACT TD-1792 is a first-in-class glycopeptide-cephalosporin heterodimer that exhibits bactericidal activity against Gram-positive pathogens. We conducted a randomized, double-blind, active-control, phase II trial in patients with complicated skin and skin structure infections caused by suspected or confirmed Gram-positive organisms. Patients 18 to 65 years old were randomized to receive 7 to 14 days of either TD-1792 (2 mg/kg of body weight intravenously [i.v.] every 24 h [q24h]) or vancomycin (1 g i.v. q12h, with dosage regimens adjusted per site-specific procedures). A total of 197 patients were randomized and received at least one dose of study medication. Rates of clinical success at the test-of-cure evaluation were similar in all analysis populations. Among 170 clinically evaluable patients, cure rates were 91.7% and 90.7% in the TD-1792 and vancomycin groups, respectively (95% confidence interval [CI] of −7.9 to 9.7 for the difference). In microbiologically evaluable patients with methicillin-resistant Staphylococcus aureus at baseline (n = 75), cure rates were 94.7% in the TD-1792 group and 91.9% in the vancomycin group. Microbiological eradication of Gram-positive pathogens (n = 126) was achieved in 93.7% and 92.1% of patients in the TD-1792 and vancomycin groups, respectively. Seven patients were discontinued from study medication due to an adverse event (AE): 2 and 5 in the TD-1792 and vancomycin groups, respectively. AEs were of similar types and severities between the two groups, other than pruritus, which was more common in patients who received vancomycin. No patients in the TD-1792 group experienced a serious AE. This study supports further clinical development of TD-1792 in patients with Gram-positive infection.
E1210, a New Broad-Spectrum Antifungal, Suppresses Candida albicans Hyphal Growth through Inhibition of Glycosylphosphatidylinositol Biosynthesis

ABSTRACT Continued research toward the development of new antifungals that act via inhibition of glycosylphosphatidylinositol (GPI) biosynthesis led to the design of E1210. In this study, we assessed the selectivity of the inhibitory activity of E1210 against Candida albicans GWT1 (Orf19.6884) protein, Aspergillus fumigatus GWT1 (AFUA_1G14870) protein, and human PIG-W protein, which can catalyze the inositol acylation of GPI early in the GPI biosynthesis pathway, and then we assessed the effects of E1210 on key C. albicans virulence factors. E1210 inhibited the inositol acylation activity of C. albicans Gwt1p and A. fumigatus Gwt1p with 50% inhibitory concentrations (IC50s) of 0.3 to 0.6 μM but had no inhibitory activity against human Pig-Wp even at concentrations as high as 100 μM. To confirm the inhibition of fungal GPI biosynthesis, expression of ALS1 protein, a GPI-anchored protein, on the surfaces of C. albicans cells treated with E1210 was studied and shown to be significantly lower than that on untreated cells. However, the ALS1 protein levels in the crude extract and the RHO1 protein levels on the cell surface were found to be almost the same. Furthermore, E1210 inhibited germ tube formation, adherence to polystyrene surfaces, and biofilm formation of C. albicans at concentrations above its MIC. These results suggested that E1210 selectively inhibited inositol acylation of fungus-specific GPI which would be catalyzed by Gwt1p, leading to the inhibition of GPI-anchored protein maturation, and also that E1210 suppressed the expression of some important virulence factors of C. albicans, through its GPI biosynthesis inhibition.
Slowly eroding lesions in multiple sclerosis

Background: At autopsy, 20%–40% of chronic multiple sclerosis (MS) lesions are labeled “slowly expanding” and feature myelin phagocytosis at the lesion edge. As pathological lesion classification relies on a single, terminal time point, the rate of lesion expansion cannot be directly measured. Objective: To study long-term volume changes in individual MS lesions. Methods: Volumes of individual lesions on proton density magnetic resonance imaging (MRI) acquired between 1992 and 2015 were measured in 22 individuals (one lesion per person). After correction for acquisition protocol, a mixed model evaluated lesion volume changes. Results: The mean (standard deviation) lesion volume at baseline was 142 (82) mL, falling to 74 (51) mL after 16 (3) years. All lesions shrank over time. Change in lesion volume did not correlate with change in supratentorial brain volume (p = 0.33). In simulations, the results could be explained by a process of slow radial expansion superimposed on substantially more rapid resorption of damaged tissue. Conclusion: We noted sustained radiological contraction of MS lesions, a surprising result given that fresh myelin breakdown products within chronic active lesions are observed relatively frequently at autopsy. Therefore, the primary pathological process in chronic lesions, even those described as “slowly expanding,” is likely to be tissue loss.
Cognitive impairment predicts disability progression and cortical thinning in MS: An 8-year study

Background: Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system (CNS). Although cognitive impairment (CI) affects a large proportion of MS patients, only few data are available about its prognostic value associated with advanced magnetic resonance imaging (MRI) metrics. Objectives: We aimed at investigating the relationship between the early CI and the disease progression over 8-year follow-up in MS patients. Methods: We conducted a retrospective 8-year longitudinal study involving 78 patients with relapsing-remitting MS, who completed neuropsychological examination and structural MRI at the time of diagnosis. Each patient was clinically evaluated every 6 months, and cortical thickness was quantified at baseline and at the end of the follow-up. Patients were classified as having normal cognition and mild or severe CI. Results: The results show that CI at the time of diagnosis is a good predictor of conversion to definite MS (p < 0.001), disability progression (p < 0.001), as well as of transition to secondary progressive phase (p < 0.001) and of cortical thinning (p < 0.001). Conclusion: We confirmed and extended the evidence that early CI might be helpful in the identification of MS patients at high risk of disability progression and poor clinical outcome and should be considered as a marker of most aggressive pathology.
DNA Duplexes with Hydrophobic Modifications Inhibit Fusion between HIV-1 and Cell Membranes

ABSTRACT Discovery of new drugs for the treatment of AIDS typically possessing unique structures associated with novel mechanisms of action has been of great importance due to the quick drug-resistant mutations of HIV-1 strains. The work presented in this report describes a novel class of DNA duplex-based HIV-1 fusion inhibitors. Hydrophobic groups were introduced into a DNA duplex skeleton either at one end, at both ends, or in the middle. These modified DNA duplexes inhibited fusion between HIV-1 and human cell membranes at micro- or submicromolar concentrations. Respective inhibitors adopted an aptamer pattern instead of a base-pairing interaction pattern. Structure-activity relationship studies of the respective DNA duplexes showed that the rigid and negatively charged DNA skeletons, in addition to the presence of hydrophobic groups, were crucial to the anti-HIV-1 activity of these compounds. A fluorescent resonance energy transfer (FRET)-based inhibitory assay showed that these duplex inhibitors interacted with the primary pocket in the gp41 N-terminal heptad repeat (NHR) instead of interacting with the lipid bilayers.
Driving Range Extension of EV With On-Road Contactless Power Transfer—A Case Study

As future electric vehicles (EVs) emerge, achievable driving range by these vehicles remains a major bottleneck. A battery EV has a fairly limited driving range per charging and takes a long time to charge. Moreover, the existing technology only enables stationary charging, which means that an EV has to be parked during the duration of its charge replenishment. Contactless power transfer (CPT) system presents the opportunity of on-road charge replenishment of EVs. This paper presents case studies which illustrate the effect of on-road charge replenishment on driving range of an EV for varying levels of power transfer by the CPT system in urban and highway driving scenarios.
Prevalence of respiratory diseases in hospitalized patients in Saudi Arabia: A 5 years study 1996-2000

OBJECTIVES: 1) To determine the prevalence of respiratory diseases and the length of stay among hospitalized patients with respiratory disorders 2) To detect the medical disorders commonly associated with respiratory diseases. MATERIALS AND METHODS: A retrospective review was done for 810 patients hospitalized with respiratory diseases in King Abdulaziz University Hospital, Jeddah, Saudi Arabia, over 5 years (January 1996 to December 2000). A special form was used to collect information from patient medical records including demographic data (such as age, sex and nationality), discharge diagnosis with other associated diseases and length of stay during hospitalization. RESULTS: Fifty-five percent of patients were males and 56.3% were Saudis. The mostly affected age group was 46-65 years (41.8%). Asthma (38.6%), chronic obstructive pulmonary disease (COPD) (17.2%), pneumonia (11.5%), lung cancer (8.4%) and tuberculosis (TB) (7.2%) had the highest prevalence among hospitalized patients. Asthma was higher among females (63.3%) than males (36.7%). In contrast, lung cancer, COPD and TB were higher among males (88.2, 66.9 and 74.1%) than females (11.8, 33.1 and 25.9%) respectively ( P P CONCLUSION: Asthma, COPD and pneumonia were the leading causes of hospitalization among patients with respiratory disorders, while diabetes and hypertension were the most commonly associated diseases.
Analysis and Enhancement of Low-Voltage Ride-Through Capability of Brushless Doubly Fed Induction Generator

This paper discusses the dynamic behavior of the brushless doubly fed induction generator during the grid faults which lead to a decrease in the generator's terminal voltage. The variation of the fluxes, back EMFs, and currents are analyzed during and after the voltage dip. Furthermore, two alternative approaches are proposed to improve the generator ride-through capability using crowbar and series dynamic resistor circuits. Appropriate values for their resistances are calculated analytically. Finally, the coupled circuit model and the generator's speed and reactive power controllers are simulated to validate the theoretical results and the effectiveness of the proposed solutions. Moreover, experiments are performed to validate the coupled circuit model used.
In Vitro Activity of Colistin (Polymyxin E) against 3,480 Isolates of Gram-Negative Bacilli Obtained from Patients in Canadian Hospitals in the CANWARD Study, 2007-2008

ABSTRACT The in vitro activity of colistin was evaluated versus 3,480 isolates of gram-negative bacilli using CLSI broth microdilution methods. The MIC90 of colistin was ≤2 μg/ml against a variety of clinically important gram-negative bacilli, including Escherichia coli, Klebsiella spp. , Enterobacter spp. , Acinetobacter baumannii, and Pseudomonas aeruginosa. All multidrug-resistant (n = 76) P. aeruginosa isolates were susceptible to colistin (MIC, ≤2 μg/ml). These data support a role for colistin in the treatment of infections caused by multidrug-resistant P. aeruginosa.
Ethical Decision-Making in an IT Context: The Roles of Personal Moral Philosophies and Moral Intensity

Information technologies (IT) have spread throughout all areas of modern society. However, the evolution of ethics that guide their use lags behind technological advances [2]. A promising approach to this problem involves identifying factors associated with ethical decision-making in an IT context. This study tests a model of ethical decision-making based on the argument that an individual’s perception of ethical issues inherent in a specific situation is fundamental to the decision-making process, and is shaped by the moral intensity of the situation [1]. Findings suggest that moral intensity: is influenced by the individual’s personal moral philosophy, age, gender, and religiosity; and subsequently influences various stages of the decision-making process. Results support the use of the moral intensity model of ethical decision-making in IT contexts, and suggest the need to further explore antecedents of the ethical decision-making process.
Design of Neutral-Point Voltage Controller of a Three-Level NPC Inverter With Small DC-Link Capacitors

A neutral-point-clamped three-level inverter with small dc-link capacitors is presented in this paper. The inverter requires zero average neutral-point current for stable neutral-point voltage. The small dc-link capacitors may not maintain capacitor voltage balance, even with zero neutral-point current. This may happen due to nonlinearities present in the circuit. This requires a fast control of the neutral-point voltage. A simple carrier-based modulation strategy which allows modeling of the neutral-point voltage dynamics as a continuous function of power drawn from the inverter is proposed. This continuous model shows that the neutral-point current is proportional to the power drawn from the inverter, and it enables the use of a well-established classical control theory for the neutral-point voltage controller design. A simple proportional integral controller is designed for the neutral-point voltage control on the basis of the continuous model. The design method for optimum performance is discussed. The implementation of the proposed modulation strategy and the controller is very simple. The controller is implemented in a 7.5-kW induction machine-based drive with only 14 μF dc-link capacitors. Also, the experimental results show that fast and stable performance of the neutral-point voltage controller are achieved and thus verify the validity of the proposed control approach.