Miracle-dz/UniFAR-FTUs huggingface dataset:
Discovery of novel anti-HIV agents via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry-based approach

ABSTRACT Introduction: In recent years, a variety of new synthetic methodologies and concepts have been proposed in the search for new pharmaceutical lead structures and optimization. Notably, the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry approach has drawn great attention and has become a powerful tool for the generation of privileged medicinal skeletons in the discovery of anti-HIV agents. This is due to the high degree of reliability, complete specificity (chemoselectivity and regioselectivity), mild conditions, and the biocompatibility of the reactants. Areas covered: Herein, the authors describe the progress thus far on the discovery of novel anti-HIV agents via the CuAAC click chemistry-based approach. Expert opinion: CuAAC click chemistry is a proven protocol for synthesizing triazole products which could serve as basic pharmacophores, act as replacements of traditional scaffold or substituent modification, be a linker of dual-target or dual-site inhibitors and more for the discovery of novel anti-HIV agents. What’s more, it also provides convenience and feasibility for dynamic combinatorial chemistry and in situ screening. It is envisioned that click chemistry will draw more attention and make more contributions in anti-HIV drug discovery in the future.
Lexical Context for Profiling Reputation of Corporate Entities

Opinion and trend mining on micro-blogs like Twitter recently attracted research interest in several fields including Information Retrieval (IR) and Natural Language Processing (NLP). However, the performance of existing approaches is limited by the quality of available training material. Moreover, explaining automatic systems' suggestions for decision support is a difficult task thanks to this lack of data. One of the promising solutions of this issue is the enrichment of textual content using large micro-blog archives or external document collections, e.g. Wikipedia. Despite some advantages in Reputation Dimension Classification (RDC) task pushed by RepLab, it remains a research challenge. In this paper we introduce a supervised classification method for RDC based on a threshold intersection graph. We analyzed the impact of various micro-blogs extension methods on RDC performance. We demonstrated that simple statistical NLP methods that do not require any external resources can be easily optimized to outperform the state-of-the-art approaches in RDC task. Then, the conducted experiments proved that the micro-blog enrichment by effective expansion techniques can improve classification quality. Lexical Context for Profiling Reputation of Corporate Entities. Available from: https://www.researchgate. net/publication/313846200_Lexical_Context_for_Profiling_Reputation_of_Corporate_Entities [accessed Jun 12, 2017].
Downregulation of Fanconi Anemia Genes in Sporadic Head and Neck Squamous Cell Carcinoma

Background/Aims: Much of our understanding of human cancer has come from studies of the hereditary cancer predisposition syndromes. Fanconi anemia (FA) is an autosomal recessive disorder characterized by cellular hypersensitivity to DNA crosslinking agents, progressive bone marrow failure, and cancer predisposition to solid malignancies, especially head and neck squamous cell carcinoma (HNSCC). Since FA pathway-deficient cells are hypersensitive to DNA crosslinking chemotherapy agents, the presence of somatic FA gene inactivation in sporadic cancers may be of clinical interest. This study sought to determine the frequency of FA gene downregulation in sporadic HNSCC. Methods: The expression of the FA genes FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCJ, FANCL and FANCM in 11 HNSCC cell lines and 49 tongue carcinoma samples was studied with quantitative real-time polymerase chain reaction. Results: Downregulation of at least one FA gene was observed in 3 of 11 HNSCC cell lines and 66% of tongue carcinoma samples. FANCB, FANCF, FANCJ and FANCM were most commonly affected by downregulation, whereas downregulation of FANCA, FANCE and FANCD2 was rare. Conclusion: Our data suggest that downregulation of FA genes is common in sporadic HNSCC. The clinical implications of this finding merit further study.
BALL-CONSTRAINED MAXIMIN DISPERSION PROBLEM 1567

The ball-constrained weighted maximin dispersion problem (Pball) is to find a point in an n-dimensional Euclidean ball such that the minimum of the weighted Euclidean distance from given m points is maximized. We propose a new second-order cone programming relaxation for (Pball). Under the condition m ≤ n, (Pball) is polynomial-time solvable since the new relaxation is shown to be tight. In general, we prove that (Pball) is NP-hard. Then, we propose a new randomized approximation algorithm for solving (Pball), which provides a new approximation bound of 1−O( √ ln(m)/n) 2 .
West Nile Virus Infection in a Sun Conure (Aratinga solstitialis)

ABSTRACT A 2-year-old sun conure (Aratinga solstitialis) was examined because of acute lethargy and depression. Physical examination revealed severe weakness with ventroflexion of the head and neck and seizure episodes precipitated by handling. Empirical and supportive care was instituted, and serial diagnostic testing revealed no specific diagnosis or etiology. Antemortem test results for West Nile virus were negative. After 2 weeks of a deteriorating clinical condition, euthanasia was elected and necropsy was performed. Gross examination revealed no significant lesions; however, histologic examination of brain tissue revealed perivascular cuffing of mononuclear inflammatory cells in the cerebrum and mild perivascular, lymphocytic, and plasmacytic infiltrates scattered in the grey matter of the cervical spinal cord. Viral isolation of brain tissue was positive for West Nile virus.
Clinical field testing of trans-femoral prosthetic technologies: Resin-wood and ICRC-polypropylene

The aim of this study was to evaluate the use of 2 different trans-femoral prosthetic systems, a conventional wood-resin design and an ICRC polypropylene design, in a developing country when implemented by teachers and their associates at an ISPO Caegory II recognised training establishment. The study was conducted at the Tanzanian Training Centre for Orthopaedic Technologists (TATCOT). Amputees were selected from a cohort of younger amputees, mostly with traumatic amputations, 27 were provided with the conventional design of prosthesis and 35 with the ICRC design. The outcome was evaluated clinically and technically after a median of 20 months (conventional) and 15 months (ICRC) respectively. For all prostheses provided the craftsmanship was considered acceptable in 71%, and patient satisfaction was assessed as 92%, patient compliance as 98%. Failures requiring a major intervention represented 32%. Both systems provided in this controlled environment were considered to give an acceptable clinical and technical result.
Inhibition of parvovirus minute virus of mice replication by a peptide involved in the oligomerization of nonstructural protein NS1

The large nonstructural protein NS1 of the minute virus of mice and other parvoviruses is involved in essential steps of the viral life cycle, such as DNA replication and transcriptional regulation, and is a major contributor to the toxic effect on host cells. Various biochemical functions, such as ATP binding, ATPase, site-specific DNA binding and nicking, and helicase activities, have been assigned to NS1. Homo-oligomerization is a prerequisite for a number of proteins to be fully functional. In particular, helicases generally act as homo-oligomers. Indirect evidence of NS1 self-association has been recently obtained by a nuclear cotransport assay (J. P. Nüesch and P. Tattersall, Virology 196:637-651, 1993). In order to demonstrate the oligomerizing property of NS1 in a direct way and localize the protein region(s) involved, the yeast two-hybrid system was used in combination with deletion mutagenesis across the whole NS1 molecule, followed by high-resolution mapping of the homo-oligomerization domain by a peptide enzyme-linked immunosorbent assay method. This study led to the identification of a distinct NS1 peptide that contains a bipartite domain involved in NS1 oligomerization. Furthermore, this isolated peptide was found to act as a specific competitive inhibitor and suppress NS1 helicase activity in vitro and parvovirus DNA replication in vivo, arguing for the involvement of NS1 oligomerization in these processes. Our results point to drug targeting of oligomerization motifs of viral regulatory proteins as a potentially useful antiviral strategy.
Aalborg Universitet Multiple Description Spherical Quantization of Sinusoidal Parameters with Repetition Coding of the Amplitudes

Recently, multiple description spherical trellis-coded quantization (MDSTCQ) for quantization of sinusoidal parameters was proposed, which suffered from a suboptimal implementation. Therefore, we propose the multiple description spherical quantization with repetition coding of the amplitudes (MDSQRA) scheme. Here, we apply repetition coding to the amplitudes, whereas the phases and the frequencies are coded using multiple description quantization. We measure the relation between the expected perceptual distortions for the two quantization schemes, which shows that MDSQRA outperforms MDSTCQ for most packet-loss probabilities. Also, we measure the perceptual distortion obtained when applying MDSQRA on synthetic data and show that it matches the expected perceptual distortion. Furthermore, due to MDSTCQs suboptimal implementation, MDSQRA outperforms MDSTCQ in terms of measured perceptual distortion even at packet-loss probabilities where the expected perceptual distortion was lowest for MDSTCQ.
Further studies into proximal interphalangeal joint dimensions for the design of a surface replacement prosthesis: Medullary cavities and transverse plane shapes

Abstract The proximal and middle phalanges from 83 proximal interphalangeal joints (PIPJs) were set in clear plastic and sectioned in the transverse plane leaving the heads whole. The sections were cleaned, shadowgraphed and measured. The medullary canals were marked on sagittal and frontal plane shadowgraphs of the intact bones and analysed. The information was then used in the design of a surface replacement prosthesis for the PIPJs. The main dorsal surface of the proximal phalanx (PP) was found to be angled to the longitudinal baseline of the bone by a mean of 5.19°. This angle increased just proximal to the phalangeal head to a mean of 11.84°. The mean ratio between these angles was 2.71. The phalangeal shaft bone was thicker laterally than dorsally and palmarly, and thicker dorsally than palmarly for the proximal and middle phalanges throughout the length of the bone. The shape and size of the transverse cross-section of the medullary canal changed throughout the length of the shaft. The centreline of the PP medullary canal coincided with the midline of the bone in the frontal plane and was approximately a straight line along the length of the canal. In the sagittal plane the centreline was slightly palmar to the midline and the angle between it and the longitudinal baseline of the bone changed along the length of the canal. In the region of the shaft just proximal to the PP head (where the stem of a surface replacement prosthesis would fit) the mean angle was 10.63°. The centreline was offset dorsally from the centre of rotation of the PIPJ by a mean of 0.83 mm, 0.83 mm, 0.80 mm and 0.57 mm for the index, middle, ring and little fingers respectively, with an overall mean of 0.76 mm. The mean PP head heights (transverse plane) were 9.17 mm, 9.33 mm, 8.73 mm and 7.40 mm and the mean PP widths (transverse plane) were 12.86 mm, 13.25 mm, 12.75 mm and 10.54 mm for the index, middle, ring and little fingers respectively. The mean angle between the lateral sides of the condyles to the transverse baseline was 78.35° and the mean distance from the centreline of the PP head (transverse plane) to the bases of the two condyles was 4.69 mm. The mean maximum depth of the PP head intercondylar sulcus in the frontal plane was 0.72 mm and in the transverse plane, the mean maximum depth of the intercondylar sulcus on the anterior face was 0.82 mm.
Object Pose Detection in Industrial Environment

This paper shows a method for object pose detection that is successfully applied to industrial applications running a three-shift system. The industrial applications are fully automated feeding systems, commonly known as bin-picking. The proposed method is a generic approach to detect 6 degrees of freedom of any solid objects with arbitrary geometry. The proposed method is using 3D range data and is based on a hypothesize-and-test approach . In the first step, object poses are hypothesized by means of pose clustering. In the second step, the verification of estimated object poses is realised by an appearance-based template-matching approach. In addition, the method? s interfaces are designed to ensure compatibility to 3D sensor systems and handling systems [5]. During long-term operations in different use-cases, the method showed its usability regarding the crucial requirements, such as robustness, accuracy, portability and speed.
The effects of dietary marine protein hydrolysates on the development of sea bass larvae, Dicentrarchus labrax, and associated microbiota

Protein hydrolysate is an essential component of dry starter diets for fish larvae, as promoting healthy development. Peptides are also suitable substrates for many intestinal microbes. Five experimental diets were compared to a control diet (CONT) supplemented with a commercial fish protein hydrolysate. Each diet contained one marine protein hydrolysate, which differed by the proportion of di- and tri-peptides, and by raw materials. Two diets (HYD4 and HYD5) stimulated larval growth compared with CONT. Two other diets (HYD1 and HYD2) yielded inferior growth. HYD1 was detrimental for survival, which was associated with an up-regulation of genes involved in inflammation and antioxidative responses, while the gene coding for osteocalcin was down-regulated in this group. The relative activity of enzymes in the brush border membrane of enterocytes was significantly stimulated with diets HYD3 and HYD4. Gut microbiota were influenced by the diet, but the bacterial community profiles observed with HYD3 and HYD4 were the only ones that were not significantly dissimilar. Groups HYD1 and HYD2 showed the most dissimilar microbiota. It was concluded that the nature of the marine protein hydrolysate is important for larval development and health, but a high proportion of small peptides is not a sufficient criterion to assess dietary value.
Identification of Small Heat Shock Protein B8 (HSP22) as a Novel TLR4 Ligand and Potential Involvement in the Pathogenesis of Rheumatoid Arthritis1

Dendritic cells (DCs) are specialized APCs that can be activated upon pathogen recognition as well as recognition of endogenous ligands, which are released during inflammation and cell stress. The recognition of exogenous and endogenous ligands depends on TLRs, which are abundantly expressed in synovial tissue from rheumatoid arthritis (RA) patients. Furthermore TLR ligands are found to be present in RA serum and synovial fluid and are significantly increased, compared with serum and synovial fluid from healthy volunteers and patients with systemic sclerosis and systemic lupus erythematosus. Identification of novel endogenous TLR ligands might contribute to the elucidation of the role of TLRs in RA and other autoimmune diseases. In this study, we investigated whether five members of the small heat shock protein (HSP) family were involved in TLR4-mediated DC activation and whether these small HSPs were present in RA synovial tissue. In vitro, monocyte-derived DCs were stimulated with recombinant αA crystallin, αB crystallin, HSP20, HSPB8, and HSP27. Using flow cytometry and multiplex cytokine assays, we showed that both αA crystallin and HSPB8 were able to activate DCs and that this activation was TLR4 dependent. Furthermore, Western blot and immunohistochemistry showed that HSPB8 was abundantly expressed in synovial tissue from patients with RA. With these experiments, we identified sHSP αA crystallin and HSPB8 as two new endogenous TLR4 ligands from which HSPB8 is abundantly expressed in RA synovial tissue. These findings suggest a role for HSPB8 during the inflammatory process in autoimmune diseases such as RA.
Considerations for Data-Mining from Sensor Information

This paper proposes a two-layer modular architecture to adaptively perform data mining tasks in large sensor networks. The architecture consists in a lower layer which performs data aggregation in a modular fashion and in an upper layer which employs an adaptive local learning technique to extract a prediction model from the aggregated information. The rationale of the approach is that a modular aggregation of sensor data can serve jointly two purposes: first, the organization of sensors in clusters, then reducing the communication effort, second, the dimensionality reduction of the data mining task, then improving the accuracy of the sensing task.
Acute effects of different types of aerobic exercise on endothelial function and arterial stiffness

Background Chronic aerobic exercise training is associated with improved endothelial function and arterial stiffness and favourable long-term cardiovascular effects. Design We investigated the acute effects of continuous moderate intensity aerobic exercise (CAE) and high intensity interval aerobic exercise (hIAE) on endothelial function and arterial stiffness in healthy participants. Methods Twenty healthy men were recruited to this cross-over study. They participated in two exercise sessions: (a) CAE, volume at 50% of maximum aerobic work for 30 minutes; and (b) hIAE, interval maximum aerobic work for 30 minutes. Endothelial function was evaluated by flow-mediated dilation in the brachial artery. The carotid femoral pulse wave velocity and the femoral dorsalis pedis pulse wave velocity were measured as indices of central aortic and peripheral arterial stiffness. Measurements were carried out before and immediately after each exercise session. Results There was no statistically significant difference in the baseline measurements before CAE and hIAE with respect to flow-mediated dilation, the carotid femoral pulse wave velocity and the femoral dorsalis pedis pulse wave velocity (p = NS). Both CAE and hIAE significantly improved the flow-mediated dilation compared with baseline (p < 0.001). Similarly, the femoral dorsalis pedis pulse wave velocity was improved after CAE and hIAE (p < 0.005), whereas the carotid femoral pulse wave velocity was not significantly affected (p = NS). Conclusion Both CAE and hIAE can favourably affect endothelial function, suggesting another cardioprotective effect of acute exercise. These types of aerobic exercise have a different impact on the central and peripheral arterial stiffness.
Towards Cooperative Self-Protecting Mobile Devices using Trustful Relationships

Security remains a major topic in today's networks. Especially in the mobile area there are many security issues that have not yet been satisfactorily addressed, let alone been solved. Most of the security mechanisms and techniques used in wired networks tend to rely upon a fixed network topology. For example, firewalls and intrusion detection systems are placed at central points of a network and configured with a model of the network's structure to control and analyse the data flows transferred for harmful content. If at all, adopting these measures for the mobile world is not easy due to its dynamically changing environments and the mobile device's resource constraints that do not allow demanding analyse tasks. In this paper, we present our work in progress of developing a system architecture for cooperative and self-protecting mobile devices. Our approach is based on the assumption that a mobile network can be protected by securing all participating devices or at least all honest participating devices. Thus, we no longer insist on a global view of the network but on several local views. To make these views as precise as possible and to avoid serious performance bottlenecks on a single device we propose a strategy for coupling trusted mobile devices together into a cooperating group
Fingerprinting Mobile Devices Using Personalized Configurations

Abstract Recently, Apple removed access to various device hardware identifiers that were frequently misused by iOS third-party apps to track users. We are, therefore, now studying the extent to which users of smartphones can still be uniquely identified simply through their personalized device configurations. Using Apple’s iOS as an example, we show how a device fingerprint can be computed using 29 different configuration features. These features can be queried from arbitrary thirdparty apps via the official SDK. Experimental evaluations based on almost 13,000 fingerprints from approximately 8,000 different real-world devices show that (1) all fingerprints are unique and distinguishable; and (2) utilizing a supervised learning approach allows returning users or their devices to be recognized with a total accuracy of 97% over time
Textmining, feature selection and datamining for proteins classification

The present study presents the classification of proteins by basing on its primary structures. The sequence of proteins collected in a file. The application of textmining technique for extracting the features is proposed. An algorithm is also developed which extracts all the n-grams existing in the file of data and produced a learning file. Algorithm supplies three files, Boolean file, that is a relation of existence or not existence, frequencies files and occurrences files. The applied forward selection and backward elimination method is a learning file with an accepted features numbers.
Bacterial foraging-based PI controller of inverter-based distributed generators

This paper introduces a new optimal technique to estimate the PI gains for current regulated inverter control. The PI controller tuning is accomplished using bacterial foraging optimization (BFO) algorithm to reduce voltage and current harmonic distortions and comply with the local grid requirements and interconnection standards. Robust and decoupled active and reactive power control is achieved. The investigation is conducted on a hybrid distributed generation (DG) unit comprising renewable-based generation with a storage unit. This kind of DG is typically is interfaced with utility grids via power electronic converters. The inverter model along with its optimized control parameters is investigated and simulated using Matlab/Simulink. Compared to trial and error tuning, PI controller that is based on BFO gives better current and voltage sinusoidal waveforms with minimum tracking error.