Miracle-dz/UniFAR-FTUs huggingface dataset:
Interface‐Modulated Resistive Switching in Mo‐Irradiated ReS2 for Neuromorphic Computing

Coupling charge impurity scattering effects and charge‐carrier modulation by doping can offer intriguing opportunities for atomic‐level control of resistive switching (RS). Nonetheless, such effects have remained unexplored for memristive applications based on 2D materials. Here a facile approach is reported to transform an RS‐inactive rhenium disulfide (ReS2) into an effective switching material through interfacial modulation induced by molybdenum‐irradiation (Mo‐i) doping. Using ReS2 as a model system, this study unveils a unique RS mechanism based on the formation/dissolution of metallic β‐ReO2 filament across the defective ReS2 interface during the set/reset process. Through simple interfacial modulation, ReS2 of various thicknesses are switchable by modulating the Mo‐irradiation period. Besides, the Mo‐irradiated ReS2 (Mo‐ReS2) memristor further exhibits a bipolar non‐volatile switching ratio of nearly two orders of magnitude, programmable multilevel resistance states, and long‐term synaptic plasticity. Additionally, the fabricated device can achieve a high MNIST learning accuracy of 91% under a non‐identical pulse train. The study's findings demonstrate the potential for modulating RS in RS‐inactive 2D materials via the unique doping‐induced charged impurity scattering property.
Obstructive sleep apnea: transition from pathophysiology to an integrative disease model

Obstructive sleep apnea (OSA) is characterised by recurring episodes of upper airway obstruction during sleep and the fundamental abnormality reflects the inability of the upper airway dilating muscles to withstand the negative forces generated within the upper airway during inspiration. Factors that result in narrowing of the oropharynx such as abnormal craniofacial anatomy, soft tissue accumulation in the neck, and rostral fluid shift in the recumbent position increase the collapsing forces within the airway. The counteracting forces of upper airway dilating muscles, especially the genioglossus, are negatively influenced by sleep onset, inadequacy of the genioglossus responsiveness, ventilatory instability, especially post arousal, and loop gain. OSA is frequently associated with comorbidities that include metabolic, cardiovascular, renal, pulmonary, and neuropsychiatric, and there is growing evidence of bidirectional relationships between OSA and comorbidity, especially for heart failure, metabolic syndrome, and stroke. A detailed understanding of the complex pathophysiology of OSA encourages the development of therapies targeted at pathophysiological endotypes and facilitates a move towards precision medicine as a potential alternative to continuous positive airway pressure therapy in selected patients.
Development and Pilot Testing of a Data-Rich Clinical Reasoning Training and Assessment Tool

Problem Clinical reasoning is a core competency for physicians and also a common source of errors, driving high rates of misdiagnoses and patient harm. Efforts to provide training in and assessment of clinical reasoning skills have proven challenging because they are either labor- and resource-prohibitive or lack important data relevant to clinical reasoning. The authors report on the creation and use of online simulation cases to train and assess clinical reasoning skills among medical students. Approach Using an online library of simulation cases, they collected data relevant to the creation of the differential diagnosis, analysis of the history and physical exam, diagnostic justification, ordering tests; interpreting tests, and ranking of the most probable diagnosis. These data were compared with an expert-created scorecard, and detailed quantitative and qualitative feedback were generated and provided to the learners and instructors. Outcomes Following an initial pilot study to troubleshoot the software, the authors conducted a second pilot study in which 2 instructors developed and provided 6 cases to 75 second-year medical students. The students completed 376 cases (average 5.0 cases per student), generating more than 40,200 data points that the software analyzed to inform individual learner formative feedback relevant to clinical reasoning skills. The instructors reported that the workload was acceptable and sustainable. Next Steps The authors are actively expanding the library of clinical cases and providing more students and schools with formative feedback in clinical reasoning using our tool. Further, they have upgraded the software to identify and provide feedback on behaviors consistent with premature closure, anchoring, and confirmation biases. They are currently collecting and analyzing additional data using the same software to inform validation and psychometric outcomes for future publications.
Merits and advances of microfluidics in the pharmaceutical field: design technologies and future prospects

Abstract Microfluidics is used to manipulate fluid flow in micro-channels to fabricate drug delivery vesicles in a uniform tunable size. Thanks to their designs, microfluidic technology provides an alternative and versatile platform over traditional formulation methods of nanoparticles. Understanding the factors that affect the formulation of nanoparticles can guide the proper selection of microfluidic design and the operating parameters aiming at producing nanoparticles with reproducible properties. This review introduces the microfluidic systems’ continuous flow (single-phase) and segmented flow (multiphase) and their different mixing parameters and mechanisms. Furthermore, microfluidic approaches for efficient production of nanoparticles as surface modification, anti-fouling, and post-microfluidic treatment are summarized. The review sheds light on the used microfluidic systems and operation parameters applied to prepare and fine-tune nanoparticles like lipid, poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles as well as cross-linked nanoparticles. The approaches for scale-up production using microfluidics for clinical or industrial use are also highlighted. Furthermore, the use of microfluidics in preparing novel micro/nanofluidic drug delivery systems is presented. In conclusion, the characteristic vital features of microfluidics offer the ability to develop precise and efficient drug delivery nanoparticles.
Bioleaching of rare‐earth elements from phosphate rock using Acidithiobacillus ferrooxidans

Phosphate rock containing rare‐earth elements (REEs) is considered one of the most promising potential secondary sources of REEs, as evidenced by large tonnages of phosphate rock mined annually. The bioleaching of REEs from phosphate rock using Acidithiobacillus ferrooxidans was done for the first time in this study, and it was found to be greater than abiotic leaching and was more environmentally friendly. The result showed that the total leaching rate of REEs in phosphate rock was 28·46% under the condition of 1% pulp concentration and pH = 2, and the leaching rates of four key rare earths, Y, La, Ce and Nd, were 35·7, 37·03, 27·92 and 32·53% respectively. The bioleaching process was found to be accomplished by bacterial contact and Fe2+ oxidation. The blank control group which contained Fe2+ was able to leach some of the rare earths, indicating that the oxidation of Fe2+ may affect the leaching of rare earths. X‐ray diffraction analysis showed that the minerals were significantly altered and the intensity of the diffraction peaks of dolomite and apatite decreased significantly after microbial action compared to the blank control, and it was observed that bacteria adhere to the mineral surface and the minerals become smooth and angular after bioleaching by scanning electron microscope, indicating that bacteria have a further effect on the rock based on Fe2+ oxidation. Finally, Fourier transform infrared spectroscopy and three‐dimensional excitation‐emission matrix fluorescence spectra analysis showed that extracellular polymeric substances participate in the bioleaching process.
“All I expect is that they accept that I am a Sami” an analysis of experiences of healthcare encounters and expectations for future care services among older South Sami in Norway

ABSTRACT The aim of this study first aims to forward our empirical knowledge of how older Sami experience healthcare encounters in Norway and what they expect in terms of future care services, and second, to forward our understanding of how more culturally safe services could be offered to the Sami population, 30 years after they were officially recognised as an Indigenous People. A qualitative interpretative and constructivist research design was used. 12 older South Sami were interviewed about their experiences with healthcare encounters, and their expectations for future care services. The results showed that the participants sometimes felt deprioritised and misunderstood by healthcare professionals. Moreover, they sometimes experienced that healthcare professionals had little or no knowledge about Sami history, culture and cosmology. They worried that they would not be accepted for being Sami if one day they would have to move into a nursing home. To conclude, the participants of this study are situated in a colonising context characterised by personal and collective experiences of accumulated discrimination that have taken place over many generations. The concepts of health equity and accumulated discrimination provide useful insights in the further development of culturally safe services for Indigenous Peoples in Norway and beyond.
Is there an emotionality effect in older adults’ source memory?

ABSTRACT The goal of our research was to investigate whether older adults show a source memory enhancement for emotionally valenced sources. Additionally, building on research on the socioemotional selectivity theory and the age-related positivity effect, we tested whether older adults show a larger enhancement for positive compared to negative (and neutral) sources than younger adults. In Experiment 1 (nold = 25, nyoung = 27), we used one positive, one negative, and one neutral picture to manipulate source valence (many-to-one mapping of items to sources), whereas, in Experiment 2 (nold = 62, nyoung = 62), we used multiple pictures per source valence category (one-to-one mapping of items to sources) to counteract potential habituation effects. In both experiments, sources had medium and matching arousal levels. Items were neutral words superimposed on the source pictures. To support an implicit, natural information processing, participants rated the words in terms of pleasantness. We analyzed memory data with a multinomial processing tree model to disentangle memory processes from guessing bias. Across both experiments, an age-related positivity effect occurred in participants’ pleasantness ratings. This effect, however, did not carry over to older adults’ source memory. That is, in source memory, we found a general emotionality effect for younger but not for older adults and no age-related positivity effect. We propose that due to older adults’ pronounced difficulties in remembering the item-to-source link (i.e., associative deficit), even a greater focus on an inherently emotional source might be insufficient to boost source memory.
In-silico study of the interactions between acylated glucagon like-peptide-1 analogues and the native receptor

Abstract We have performed a series of multiple molecular dynamics (MD) simulations of glucagon-like peptide-1 (GLP-1) and acylated GLP-1 analogues in complex with the endogenous receptor (GLP-1R) to obtain a molecular understanding of how fatty acid (FA) chain structure, acylation position on the peptide, and presence of a linker affect the binding. MD simulations were analysed to extract heatmaps of receptor–peptide interaction patterns and to determine the free energy of binding using the molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) approach. The extracted free energies from MM-PBSA calculations are in qualitative agreement with experimentally determined potencies. Furthermore, the interaction patterns seen in the receptor–GLP-1 complex simulations resemble previously reported binding interactions validating the simulations. Analysing the receptor–GLP-1 analogue complex simulations, we found that the major differences between the systems stem from FA interactions and positioning of acylation in the peptide. Hydrophobic interactions between the FA chain and a hydrophobic patch on the extracellular domain contribute significantly to the binding affinity. Acylation on Lys26 resulted in noticeably more interactions between the FA chain and the extracellular domain hydrophobic patch than found for acylation on Lys34 and Lys38, respectively. The presence of a charged linker between the peptide and FA chain can potentially stabilise the complex by forming hydrogen bonds to arginine residues in the linker region between the extracellular domain and the transmembrane domain. A molecular understanding of the fatty acid structure and its effect on binding provides important insights into designing acylated agonists for GLP-1R. Communicated by Ramaswamy H. Sarma
Parabiosis in Mice to Study Tissue Residency of Immune Cells

Different populations of immune cells rely on their distinct migration patterns for immunosurveillance, immune regulation, tissue specific differentiation, and maturation. It is often important to clarify whether cells are recirculating or tissue resident, or whether tissue‐specific cells are derived from blood‐borne precursors or a tissue‐resident population. Though migration or tissue residency of immune cells critically depends on the expression of different homing molecules (chemokine receptors, tissue retention molecules, etc.), characterization based solely on the expression of homing molecules may not faithfully reflect the migration patterns of immune cells. Therefore, a more reliable method to clarify migration patterns of immune cells is required. Parabiosis is a surgical connection of two mice resulting in a shared circulatory system, which allows reliable distinction of tissue‐resident and circulating cells. Here, we describe a set of protocols for parabiosis, including technique details, pitfalls, and suggestions for optimization and troubleshooting. © 2022 Wiley Periodicals LLC.
Decoding point‐light displays and fully visible hand grasping actions within the action observation network

Action observation typically recruits visual areas and dorsal and ventral sectors of the parietal and premotor cortex. This network has been collectively termed as extended action observation network (eAON). Within this network, the elaboration of kinematic aspects of biological motion is crucial. Previous studies investigated these aspects by presenting subjects with point‐light displays (PLDs) videos of whole‐body movements, showing the recruitment of some of the eAON areas. However, studies focused on cortical activation during observation of PLDs grasping actions are lacking. In the present functional magnetic resonance imaging (fMRI) study, we assessed the activation of eAON in healthy participants during the observation of both PLDs and fully visible hand grasping actions, excluding confounding effects due to low‐level visual features, motion, and context. Results showed that the observation of PLDs grasping stimuli elicited a bilateral activation of the eAON. Region of interest analyses performed on visual and sensorimotor areas showed no significant differences in signal intensity between PLDs and fully visible experimental conditions, indicating that both conditions evoked a similar motor resonance mechanism. Multivoxel pattern analysis (MVPA) revealed significant decoding of PLDs and fully visible grasping observation conditions in occipital, parietal, and premotor areas belonging to eAON. Data show that kinematic features conveyed by PLDs stimuli are sufficient to elicit a complete action representation, suggesting that these features can be disentangled within the eAON from the features usually characterizing fully visible actions. PLDs stimuli could be useful in assessing which areas are recruited, when only kinematic cues are available, for action recognition, imitation, and motor learning.
Prevalence of gambling problems, help-seeking, and relationships with trauma in veterans

Background and aims Veterans who have recently left the military (i.e., transitioned) may be vulnerable to the development of psychiatric disorders, but little is known about gambling problems in this population. This study investigated the prevalence and risk factors of gambling problems, help-seeking amongst veterans with gambling problems, and relationships with trauma and posttraumatic psychopathology. Methods Cross-sectional self-report survey data from 3,511 Australian Defence Force members who left the military within the past five years. Surveys included measures of gambling problems (PGSI); depressive symptoms (PHQ-9); posttraumatic stress disorder (PCL-5); help-seeking behaviours; military and non-military-related trauma. Results Prevalence rates for problem gambling (PGSI ≥ 5) were 4.6%, while an additional 8.8% were classified in terms of at-risk gambling (PGSI = 1–4). Time since leaving the military was not associated with gambling problems. Only 2.1% of veterans with problem gambling reported help-seeking for their gambling. While trauma exposure, depression, and Posttraumatic Stress Disorder (PTSD) were all related to gambling problems at the bivariate level, only arousal and dysphoric-related affect were uniquely associated with gambling problems when adjusting for covariates. Discussion Gambling problems may be under-recognised relative to other psychiatric issues. Posttraumatic mental health problems, rather than trauma exposure per se, may explain the relationship between trauma and gambling problems. Conclusions Some veterans are in a period of vulnerability during transition out of military service, and harms associated with gambling problems may be exacerbated during this period.
Civilian Petitioners and Extreme Risk Protection Orders in the State of Washington.

OBJECTIVE Extreme risk protection orders (ERPOs) are civil orders designed to temporarily restrict access to firearms when people are at substantial risk of harm to themselves or others. A minority of ERPOs in the United States have been filed by civilians, with most filed by law enforcement. The authors examined barriers and facilitators to the ERPO filing process from the perspective of the civilian petitioner. METHODS Semistructured interviews of civilian petitioners who filed ERPOs in Washington State from December 2016 to September 2020 were conducted. The interviews examined both barriers and facilitators to filing an ERPO. A descriptive and qualitative approach with inductive-deductive thematic analysis was used to identify and code themes. RESULTS Fifteen civilian petitioners were interviewed. Barriers to ERPO filing included perceived lack of help connecting with social services to address the potential for harmful behavior, confusion regarding the filing and court process, and petitioner distress. Facilitators included having previous legal experience, having assistance from advocates who helped shepherd petitioners through the process, and simplification of the ERPO process. CONCLUSIONS ERPO is a useful tool for suicide and violence prevention, but several barriers may be inhibiting ERPO use among civilian petitioners. Better educational resources and advocacy programs, as well as simplified filing steps, could improve the process and make ERPOs more accessible for civilians.
Design and kinematic of a dexterous bioinspired elephant trunk robot with variable diameter

How to further improve the dexterity of continuum robots so that they can quickly change their structural size like flexible biological organs is a key challenge in the field of robotics. To tackle this dexterity challenge, this paper proposes a soft-rigid coupled bioinspired elephant trunk robot with variable diameter, which is enabled by combining a soft motion mechanism with a novel rigid variable-diameter mechanism (double pyramid deployable mechanism). The integration of these two mechanisms has produced three significant beneficial effects: (i) The coexistence of multi-degree-of-freedom motion capability and variable size function greatly improves the dexterity of the elephant trunk robot. (ii) The motion refinement can be improved by structural amplification, making up for the low resolution of soft actuators. (iii) Its stiffness can be increased by enlarging its diameter, while its reachable workspace can be increased by decreasing its diameter. Thus, the elephant trunk robot can optimize its performance when facing different tasks by opening and closing the rigid variable-diameter mechanism. Further, we established a kinematic model of the elephant trunk robot by the structure discretization method and the principle of mechanism equivalence, and experimentally verified its reasonableness. The demonstration experiments show that the elephant trunk robot has good flexibility. This work provides a new variable diameter configuration for continuum robots, and presents a method of how to analyze the kinematics of continuum mechanisms using rigid mechanism theory.
CIS and TGF‐β regulatory pathways influence immunity to bacterial infection

Immunotherapy has revolutionized cancer therapy by reactivating tumour‐resident cytotoxic lymphocytes. More recently, immunotherapy has emerged to restore immunity against infectious agents, including bacterial infections. Immunotherapy primarily targets inhibitory pathways in T cells, however interest in other effector populations, such as natural killer (NK) cells, is growing. We have previously discovered that NK cell metabolism, proliferation and activation can be neutralized through the immunosuppressive transforming growth factor (TGF)‐β pathway by inducing plasticity of NK cells and differentiation into innate lymphoid cell (ILC)1‐like subsets. NK cells are also regulated through cytokine‐inducible SH2‐containing protein (CIS), which is induced by interleukin (IL)‐15 and is a potent intracellular checkpoint suppressing NK cell survival and function. Targeting these two distinct pathways to restore NK cell function has shown promise in cancer models, but their application in bacterial infection remains unknown. Here, we investigate whether enhancement of NK cell function can improve anti‐bacterial immunity, using Salmonella Typhimurium as a model. We identified conversion of NK cells to ILC1‐like for the first time in the context of bacterial infection, where TGF‐β signalling contributed to this plasticity. Future study should focus on identifying further drivers of ILC1 plasticity and its functional implication in bacterial infection model. We further describe that CIS‐deficient mice displayed enhanced pro‐inflammatory function and dramatically enhanced anti‐bacterial immunity. Inhibition of CIS may present as a viable therapeutic option to enhance immunity towards bacterial infection.