Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effects of Valence and Arousal on Time Perception in Depressed Patients

Purpose The aim of the present study was to examine the effects of emotional state on time perception in patients with depression and to investigate if time perception in patients with depression could be changed by induced emotional state. Patients and Methods A clinically-depressed (CD, n=19) and non-depressed (ND, n=22) group viewed four video clips of different levels of valence and arousal (ie, positive-high arousal, positive-low arousal, negative-high arousal, negative-low arousal). After inducing emotion state, all participants performed a time perception task to measure differences in the perception of time. Results The results showed that the CD group perceived time passing more slowly than the ND group at baseline and in all conditions, especially in the negative-low arousal condition. The ND group perceived time passed more quickly in the positive-high arousal condition compared to the CD group. These results indicate that emotional state with combined valence and arousal factors could change time perception in patients with depression. Conclusion Based on these results, it is suggested that changing the emotional state of the depressive patient by considering valence as well as arousal is important to improve the distortion on time perception.
5,6-Dioxo-1,10-phenanthrolin-1-ium bromide at 120 K

The title compound, C12H7N2O2+·Br− is, to our knowledge, the first reported example of a simple salt of cationic mono-N-protonated 1,10-phenanthroline-5,6-dione. All of the atoms lie on a crystallographic mirror plane and the cation is therefore totally planar. As a consequence, the compound has a well defined layer structure in which N—H⋯Br, C—H⋯Br and C—H⋯O contacts within the layers interconnect the ionic species.
Results of a Glaucoma Shared Care Model Using the Enhanced Glaucoma Staging System and Disc Damage Likelihood Scale with a Novel Scoring Scheme in New Zealand

Purpose To report the results of a scheme sharing follow-up glaucoma consultations between community optometrists and secondary care in a hospital ophthalmic clinic. Patients and Methods Optometrists measured intraocular pressure (IOP) with Goldmann Tonometry, graded the optic disc with the Disc Damage Likelihood Score (DDLS) and graded visual field tests with the enhanced Glaucoma Staging Score (eGSS). A scoring system from these tests was applied, and patients were either seen routinely 6 months later within the scheme or returned non-routinely to secondary care. Appointments within the scheme were 6-monthly with the pattern of three community optometrist visits then one hospital clinic visit. Results Community optometrists conducted 529 appointments for 285 patients. A total of 114 patients were seen after non-routine return to secondary care, with 61 true positives (53.5%) and 53 false positives (46.5%). Forty-one patients (14.4%) developed glaucoma progression, and 18 patients (6.3%) developed new non-glaucomatous ophthalmic diseases. Fifty-two patients were seen at 2 years after the routine return to secondary care, and three had glaucoma progression, with scheme specificity of 94.2%. The overall false-positive returns to secondary care from eGSS alone was 7.4%, and from the DDLS was 0.01%. Conclusion The DDLS and eGSS performed well for this population and would be recommended for use in shared care schemes, and the scoring scheme fulfilled its clinical and clerical purposes. Secondary care appointments are recommended in shared care schemes to manage the expected comorbidities and glaucoma progression, and prevent sight loss from false negatives.
Potential Impact of Local Anesthetics Inducing Granulocyte Arrest and Altering Immune Functions on Perioperative Outcome

Introduction Local anesthetics (LAs) are frequently used during anesthesia; however, they may influence granulocyte function which in turn could modify immune responses in the perioperative period. Therefore, the aim of this study was to investigate the impact of clinically used doses of bupivacaine and lidocaine on granulocyte function with regard to migration, reactive oxygen species (ROS) production, neutrophil extracellular traps (NETosis) formation, and viability. Methods A total of 38 granulocyte-enriched samples from healthy subjects were obtained by whole blood lysis. Polymorphonuclear neutrophil (PMN) samples were incubated simultaneously with different concentrations of either bupivacaine (0.03–3.16 mmol/L) or lidocaine (0.007–14.21 mmol/L), or without drug (control). Live cell imaging was conducted in order to observe granulocyte chemotaxis, migration, ROS production, and NETosis. Flow cytometry was used to analyze viability and antigen expression. Results The track length (TL) of PMNs exposed to bupivacaine concentrations of 0.16 mmol/L and above significantly decreased compared to the control. Low concentrations of lidocaine were associated with slight but significant increases in TL, whereas this changed with concentrations above 1.4 mmol/L, showing a significant decrease in TL. PMN incubated with bupivacaine concentrations of 1.58 mmol/L and above or lidocaine concentrations of at least 3.6 mmol/L showed no migration or chemotaxis at all. Time to onset of maximal ROS production and time for half-maximal NETosis decreased in a dose-dependent manner for both substances. Equipotency in NETosis induction was reached by bupivacaine (1.1 mmol/L) at significantly lower concentrations than lidocaine (7.96 mmol/L). Cell viability and oxidative burst were unaffected by LAs. Conclusion Local anesthetics in clinically used doses ameliorate granulocyte defense mechanisms, thus indicating their potentially decisive effect during the perioperative period.
Prognostic significance of KRT19 in Lung Squamous Cancer

Backgroud: Keratin 19 (KRT19) is the intermediate filament that constitutes the cytoskeleton and regulates cell-cycle and cell death. Objective: We aimed to assess whether KRT19 was involved in lung cancer development. Methods: The expression of KRT19 in lung cancer was evaluated from mRNA expression on open databse and protein abundance on tumor tissue array. Results: Using open microarray gene expression datasets and differential expression analysis, we found that KRT19 was upregulated in lung cancer compared with normal tissue. Further analysis suggested that KRT19 mRNA expression was correlated with tumor progression and overall survival in lung cancer patients. As KRT19 was overexpressed in adenocarcinoma (AC) and squamous cell carcinoma (SCC), we examined the prognostic value of KRT19 protein abundance by tissue microarray (TMA). The results suggested that protein expression of KRT19 was significantly associated with overall survival of SCC. Conclusions: Giving the prognostic role of KRT19 in lung cancer, KRT19 could be considered as an potential molecular marker in lung cancer, especially in SCC.
Magnetism in transition metals at finite temperatures: I. Computational model

Considerable evidence indicates that in Fe above the Curie temperature the electron system forms local magnetic moments which are relatively stable in magnitude and rotate to destroy long-range order. The local moments arise from exchange polarisation of the electron gas in a similar way to the conventional picture of the ferromagnetic ground state of the metal. The authors set up a one-electron-like Hartree-Fock-like model with a Stoner-like intra-atomic exchange interaction for calculating the electronic structure of such a system with arbitrary directions for the atomic moments. The directions for a cluster of 500-1000 atoms are assumed and fed into the calculation, from which the magnitudes of the moments are computed self-consistently using Haydock's recursion method (1980). The total energies are also obtainable. Results are presented for two simple types of magnetic configuration: spin spirals represent a smooth variation of the direction of magnetisation whereas alternating tilts form a rough variation back and forth from atom to atom.
Namodenoson in Advanced Hepatocellular Carcinoma and Child–Pugh B Cirrhosis: Randomized Placebo-Controlled Clinical Trial

Simple Summary We conducted a phase II randomized placebo-controlled trial to investigate namodenoson, an A3 adenosine-receptor agonist, as 2nd-line treatment for advanced hepatocellular carcinoma and moderate hepatic dysfunction (Child–Pugh [CP] scores of 7–9). The study included 50 patients in the namodenoson arm and 28 patients in the placebo arm. No overall survival advantage was observed with namodenoson; however, in patients with CP score of 7 (34 namodenoson-treated, 22 placebo-treated), namodenoson was associated with a significant improvement in 12-month overall survival (44% versus 18%, p = 0.028). Response rates were determined in patients with ≥1 assessment post-baseline (34 namodenoson-treated, 21 placebo-treated). Partial response was achieved by 3 (8.8%) namodenoson-treated and 0 (0%) placebo-treated patients. Namodenoson was well-tolerated, with a safety profile comparable to that of the placebo group. No treatment-related deaths were reported. In conclusion, namodenoson demonstrated a favorable safety profile and a preliminary efficacy signal in the evaluated population. Abstract Namodenoson, an A3 adenosine-receptor agonist, showed promising results in advanced hepatocellular carcinoma (HCC) and moderate hepatic dysfunction (Child–Pugh B; CPB) in a phase I/II clinical study. This phase II study investigated namodenoson as second-line therapy in such patients. Patients were randomized 2:1 to twice a day (BID) namodenoson (25 mg; n = 50) or placebo (n = 28). The primary endpoint (overall survival [OS]) was not met. Median OS was 4.1/4.3 months for namodenoson/placebo (hazard ratio [HR], 0.82; 95% confidence interval [CI] 0.49–1.38; p = 0.46). Pre-planned subgroup analysis of CPB7 patients (34 namodenoson-treated, 22 placebo-treated) showed a nonsignificant improvement in OS/progression-free survival (PFS). OS: 6.9 versus 4.3 months; HR, 0.81; 95% CI: 0.45–1.43, p = 0.46. PFS: 3.5 versus 1.9 months; HR, 0.89; 95% CI: 0.51–1.55, p = 0.67 (log-rank test). The difference in 12-month OS was significant (44% versus 18%, p = 0.028). Response rates were determined in patients for whom ≥ 1 assessment post-baseline was available (34 namodenoson-treated, 21 placebo-treated). Partial response was achieved by 3/34 (8.8%) and 0/21 (0%) patients, respectively. Namodenoson was well-tolerated, with a safety profile comparable to that of the placebo group. No treatment-related deaths were reported; no patients withdrew due to toxicity. In conclusion, namodenoson demonstrated a favorable safety profile and a preliminary efficacy signal in HCC CPB.
Synergistic Effect of Biosynthesized Silver Nanoparticles and Natural Phenolic Compounds against Drug-Resistant Fish Pathogens and Their Cytotoxicity: An In Vitro Study

Fish pathogens causing disease outbreaks represent a major threat to aquaculture industry and food security. The aim of the presented study is to develop safe and effective bioactive agents against two bacterial isolates: Aeromonas hydrophila and Pseudomonas fluorescens. We employed a broth microdilution method to investigate the antibacterial effect of biosynthesized silver nanoparticles (AgNPs); rutin, a natural flavonoid extracted from Ruta graveneoles; and heliomycin, a secondary metabolite produced by marine actinomycetes AB5, as monotherapeutic agents. Moreover, AgNPs in combination with rutin (AgNP + R) and heliomycin (AgNPs + H) were examined for their synergistic effect. The cytotoxic effect of individual bioactive compounds and in combination with AgNPs was investigated on epithelioma papulosum cyprini (EPC) fish cell lines. Individual treatment of AgNPs, rutin, and heliomycin exhibited a dose-dependent antimicrobial activity against A. hydrophila and P. fluorescens. Rutin minimum inhibitory concentration (MIC) showed the lowest cytotoxicity when tested on EPC cell lines, while heliomycin MIC was highly cytotoxic. Combined subtherapeutic doses of AgNPs + R and AgNPs + H displayed additive and synergistic effects against A. hydrophila and P. fluorescens, respectively, with improved results and relative safety profile. The study findings demonstrate that a combination of AgNPs and natural bioactive compounds may represent novel therapeutics fighting fish pathogens potentially affecting the fish farming industry.
Zur Elektrodynamik turbulent bewegter leitender Medien

This paper deals with the behaviour of electromagnetic fields in electrically conducting media carrying out turbulent motions. The basis is formed by Maxwell’s and the corresponding constitutive equations inclusive Ohm’s law, all with the neglections usual in magnetohydrodynamics. Attention is directed to certain mean fields defined by statistical averaging. From the equations mentioned above, except Ohm’s law, one gets equations of the same kind for the mean fields. In Ohm’s law, however, the transition to the mean fields leads to an additional term , the averaged vector product of the fluctuations in the velocity of the medium and the magnetic flux density. The investigation of this term makes up the centre in the elaboration of an electrodynamics of mean fields. As a very simple example a homogeneous isotropic turbulence showing reflexion symmetry is considered. In this case makes allowance for the introduction of a modified electrical conductivity. If the reflexion symmetry is violated, describes an effect allowing a dynamo action. Furthermore, a general method for calculation of for arbitrary turbulent motions is developed, and a survey is given of the results which can be expected for some special kinds of turbulence.
RF-Powered Low-Energy Sensor Nodes for Predictive Maintenance in Electromagnetically Harsh Industrial Environments

This work describes the design, implementation, and validation of a wireless sensor network for predictive maintenance and remote monitoring in metal-rich, electromagnetically harsh environments. Energy is provided wirelessly at 2.45 GHz employing a system of three co-located active antennas designed with a conformal shape such that it can power, on-demand, sensor nodes located in non-line-of-sight (NLOS) and difficult-to-reach positions. This allows for eliminating the periodic battery replacement of the customized sensor nodes, which are designed to be compact, low-power, and robust. A measurement campaign has been conducted in a real scenario, i.e., the engine compartment of a car, assuming the exploitation of the system in the automotive field. Our work demonstrates that a one radio-frequency (RF) source (illuminator) with a maximum effective isotropic radiated power (EIRP) of 27 dBm is capable of transferring the energy of 4.8 mJ required to fully charge the sensor node in less than 170 s, in the worst case of 112-cm distance between illuminator and node (NLOS). We also show how, in the worst case, the transferred power allows the node to operate every 60 s, where operation includes sampling accelerometer data for 1 s, extracting statistical information, transmitting a 20-byte payload, and receiving a 3-byte acknowledgment using the extremely robust Long Range (LoRa) communication technology. The energy requirement for an active cycle is between 1.45 and 1.65 mJ, while sleep mode current consumption is less than 150 nA, allowing for achieving the targeted battery-free operation with duty cycles as high as 1.7%.
The secretome mouse provides a genetic platform to delineate tissue-specific in vivo secretion

Significance Serum is a complex mixture of proteins that originate from a wide range of cells and tissues. At present, it is impossible to know what set of proteins any given tissue contributes to the circulating proteome. Here, we describe a genetic model called the secretome mouse. We show this transgenic mouse, which employs proximity biotinylation, provides a robust strategy for delineating the tissue-specific secretome. We demonstrate the utility of the secretome mouse by identifying the set of in vivo proteins secreted by endothelial cells as well as by skeletal muscle with and without exercise. This genetic strategy should, therefore, be useful in delineating a wide range of in vivo physiology and for the rational development of disease-relevant biomarkers. At present, it remains difficult to deconvolute serum in order to identify the cell or tissue origin of a given circulating protein. Here, by exploiting the properties of proximity biotinylation, we describe a mouse model that enables the elucidation of the in vivo tissue-specific secretome. As an example, we demonstrate how we can readily identify in vivo endothelial-specific secretion as well as how this model allows for the characterization of muscle-derived serum proteins that either increase or decrease with exercise. This genetic platform should, therefore, be of wide utility in understanding normal and disease physiology and for the rational design of tissue-specific disease biomarkers.
Polymorphisms in Pepsinogen C and miRNA Genes Associate with High Serum Pepsinogen II in Gastric Cancer Patients

Background: Pepsinogen (PG) II (PGII) is a serological marker used to estimate the risk of gastric cancer but how PGII expression is regulated is largely unknown. It has been suggested that PGII expression, from the PGC (Progastricsin) gene, is regulated by microRNAs (miRNA), but how PGII levels vary with Helicobacter pylori (H. pylori) infection and miRNAs genotype remains unclear. Methods: Serum levels of PGI and PGII were determined in 80 patients with gastric cancer and persons at risk for gastric cancer (74 first-degree relatives of patients, 62 patients with autoimmune chronic atrophic gastritis, and 2 patients with dysplasia), with and without H. pylori infection. As control from the general population, 52 blood donors were added to the analyses. Associations between PGII levels and genetic variants in PGC and miRNA genes in these groups were explored based on H. pylori seropositivity and the risk for gastric cancer. The two-dimensional difference in gel electrophoresis (2D-DIGE) and the NanoString analysis of messenger RNA (mRNAs) from gastric cancer tissue were used to determine the pathways associated with increased PGII levels. Results: PGII levels were significantly higher in patients with gastric cancer, and in those with H. pylori infection, than in other patients or controls. A PGI/PGII ratio ≤ 3 was found better than PGI < 25 ng/mL to identify patients with gastric cancer (15.0% vs. 8.8%). For two genetic variants, namely rs8111742 in miR-Let-7e and rs121224 in miR-365b, there were significant differences in PGII levels between genotype groups among patients with gastric cancer (p = 0.02 and p = 0.01, respectively), but not among other study subjects. Moreover, a strict relation between rs9471643 C-allele with H. pylori infection and gastric cancer was underlined. Fold change in gene expression of mRNA isolated from gastric cancer tissue correlated well with polymorphism, H. pylori infection, increased PGII level, and pathway for bacteria cell entry into the host. Conclusions: Serum PGII levels depend in part on an interaction between H. pylori and host miRNA genotypes, which may interfere with the cut-off of PGI/PGII ratio used to identify persons at risk of gastric cancer. Results reported new findings regarding the relation among H. pylori, PGII-related host polymorphism, and genes involved in this interaction in the gastric cancer setting.
Mitochondrial DNA Replacement Techniques to Prevent Human Mitochondrial Diseases

Background: Mitochondrial DNA (mtDNA) diseases are a group of maternally inherited genetic disorders caused by a lack of energy production. Currently, mtDNA diseases have a poor prognosis and no known cure. The chance to have unaffected offspring with a genetic link is important for the affected families, and mitochondrial replacement techniques (MRTs) allow them to do so. MRTs consist of transferring the nuclear DNA from an oocyte with pathogenic mtDNA to an enucleated donor oocyte without pathogenic mtDNA. This paper aims to determine the efficacy, associated risks, and main ethical and legal issues related to MRTs. Methods: A bibliographic review was performed on the MEDLINE and Web of Science databases, along with searches for related clinical trials and news. Results: A total of 48 publications were included for review. Five MRT procedures were identified and their efficacy was compared. Three main risks associated with MRTs were discussed, and the ethical views and legal position of MRTs were reviewed. Conclusions: MRTs are an effective approach to minimizing the risk of transmitting mtDNA diseases, but they do not remove it entirely. Global legal regulation of MRTs is required.
Online Extraction of Pose Information of 3D Zigzag-Line Welding Seams for Welding Seam Tracking

Three-dimensional (3D) zigzag-line welding seams are found extensively in the manufacturing of marine engineering equipment, heavy lifting equipment, and logistics transportation equipment. Currently, due to the large amount of calculation and poor real-time performance of 3D welding seam detection algorithms, real-time tracking of 3D zigzag-line welding seams is still a challenge especially in high-speed welding. For the abovementioned problems, we proposed a method for the extraction of the pose information of 3D zigzag-line welding seams based on laser displacement sensing and density-based clustering point cloud segmentation during robotic welding. after thee point cloud data of the 3D zigzag-line welding seams was obtained online by the laser displacement sensor, it was segmented using theρ-Approximate DBSCAN (Density-Based Spatial Clustering of Applications with Noise) algorithm. In the experiment, high-speed welding was performed on typical low-carbon steel 3D zigzag-line welding seams using gas metal arc welding. The results showed that when the welding velocity was 1000 mm/min, the proposed method obtained a welding seam position detection error of less than 0.35 mm, a welding seam attitude estimation error of less than two degrees, and the running time of the main algorithm was within 120 ms. Thus, the online extraction of the pose information of 3D zigzag-line welding seams was achieved and the requirements of welding seam tracking were met.
The effect of sertraline on emotional processing: secondary analyses of the PANDA randomised controlled trial

Abstract Background According to the cognitive neuropsychological model, antidepressants reduce symptoms of depression and anxiety by increasing positive relative to negative information processing. Most studies of whether antidepressants alter emotional processing use small samples of healthy individuals, which lead to low statistical power and selection bias and are difficult to generalise to clinical practice. We tested whether the selective serotonin reuptake inhibitor (SSRI) sertraline altered recall of positive and negative information in a large randomised controlled trial (RCT) of patients with depressive symptoms recruited from primary care. Methods The PANDA trial was a pragmatic multicentre double-blind RCT comparing sertraline with placebo. Memory for personality descriptors was tested at baseline and 2 and 6 weeks after randomisation using a computerised emotional categorisation task followed by a free recall. We measured the number of positive and negative words correctly recalled (hits). Poisson mixed models were used to analyse longitudinal associations between treatment allocation and hits. Results A total of 576 participants (88% of those randomised) completed the recall task at 2 and 6 weeks. We found no evidence that positive or negative hits differed according to treatment allocation at 2 or 6 weeks (adjusted positive hits ratio = 0.97, 95% CI 0.90–1.05, p = 0.52; adjusted negative hits ratio = 0.99, 95% CI 0.90–1.08, p = 0.76). Conclusions In the largest individual placebo-controlled trial of an antidepressant not funded by the pharmaceutical industry, we found no evidence that sertraline altered positive or negative recall early in treatment. These findings challenge some assumptions of the cognitive neuropsychological model of antidepressant action.