Miracle-dz/UniFAR-FTUs huggingface dataset:
STATE-OF-THE-ART OF NEW MATERIALS AND FUTURE PERSPECTIVES ON SUPER LONG SPAN BRIDGES

In this study, feasibility of using new materials for super long bridges to extend the length of center span will be discussed. First, Carbon-Fiber Reinforced Plastic (CFRP) material will be introduced. When examined in contrast, superiority of CFRP material’s structural properties, such as unit weight, tensile strength etc., over conventional steel wire will be emphasized. Then a trial concept design, 5,000m center span length, will be exhibited, followed by addressing the technical issues of CFRP material to be solved. Furthermore, practical stateof-the-art and recent advances in high-strength steel wire will be presented. ThermoMechanical Controlled Process (TMCP) and conventional steel wire production technologies will be reviewed. Two types of high performance steel produced by using TMCP which show improved yield strength, welding workability, formability and fatigue life when compared to conventional steel will be investigated. Finally, future super long bridge project plans in Japan will be introduced.
LncRNA PCAT19 induced by SP1 and acted as oncogene in gastric cancer competitively binding to miR429 and upregulating DHX9

Increasing evidence suggests that long non-coding RNAs (lncRNAs) are crucial in cancer biological processes. To investigate if lncRNA contributes to gastric cancer (GC), we conducted a bioinformatics analysis in human microarray datasets, and the results showed that lncRNA prostate cancer-associated transcript 19 (PCAT19) was upregulated in GC. Quantitative reverse-transcriptase PCR and in situ hybridization assays also revealed that PCAT19 was upregulated in GC tissues. The PCAT19 expression in GC was significantly related to tumor size, lymph node metastasis, and pathological stage. Moreover, patients with higher PCAT19 expression levels were more likely to have a poor prognosis for overall survival. The knockdown of PCAT19 by siRNA significantly suppressed the proliferation and invasion of GC cells. The cell distribution of PCAT19 in GC cells was examined by fluorescence in situ hybridization assay, and the results showed that it was mainly located in the cytoplasm. Mechanistically, PCAT19 sponges miR-429 and promotes DHX9 expression. In addition, the transcription factor SP1 is involved in PCAT19 activation. Our results demonstrate that lncRNA PCAT19 is induced by SP1 and acts as an oncogene in GC that competitively binds to miR429 and upregulates DHX9.
The Global Water Body Layer from TanDEM-X Interferometric SAR Data

The interferometric synthetic aperture radar (InSAR) data set, acquired by the TanDEM-X (TerraSAR-X add-on for Digital Elevation Measurement) mission (TDM), represents a unique data source to derive geo-information products at a global scale. The complete Earth’s landmasses have been surveyed at least twice during the mission bistatic operation, which started at the end of 2010. Examples of the delivered global products are the TanDEM-X digital elevation model (DEM) (at a final independent posting of 12 m × 12 m) or the TanDEM-X global Forest/Non-Forest (FNF) map. The need for a reliable water product from TanDEM-X data was dictated by the limited accuracy and difficulty of use of the TDX Water Indication Mask (WAM), delivered as by-product of the global DEM, which jeopardizes its use for scientific applications, as well. Similarly as it has been done for the generation of the FNF map; in this work, we utilize the global data set of TanDEM-X quicklook images at 50 m × 50 m resolution, acquired between 2011 and 2016, to derive a new global water body layer (WBL), covering a range from −60∘ to +90∘ latitudes. The bistatic interferometric coherence is used as the primary input feature for performing water detection. We classify water surfaces in single TanDEM-X images, by considering the system’s geometric configuration and exploiting a watershed-based segmentation algorithm. Subsequently, single overlapping acquisitions are mosaicked together in a two-step logically weighting process to derive the global TDM WBL product, which comprises a binary averaged water/non-water layer as well as a permanent/temporary water indication layer. The accuracy of the new TDM WBL has been assessed over Europe, through a comparison with the Copernicus water and wetness layer, provided by the European Space Agency (ESA), at a 20 m × 20 m resolution. The F-score ranges from 83%, when considering all geocells (of 1∘ latitudes × 1∘ longitudes) over Europe, up to 93%, when considering only the geocells with a water content higher than 1%. At global scale, the quality of the product has been evaluated, by intercomparison, with other existing global water maps, resulting in an overall agreement that often exceeds 85% (F-score) when the content in the geocell is higher than 1%. The global TDM WBL presented in this study will be made available to the scientific community for free download and usage.
A Fuzzy Model Integrated with Electrofacies Characterization for Permeability Prediction

A new integrated model of statistical pre-treatment and fuzzy logic is developed to predict unknown permeabilities from well logs. The log treatment based on factor analysis and clustering characterizes statistically electrofacies that are the input variables of fuzzy logic. The applicability is verified in the heterogeneous carbonate reservoir, which shows the complex and anti-persistent permeability sequence. Electrofacies helps to improve the predictability of fuzzy prediction by showing the reduction of the prediction error up to 2.3%. The estimation is stable even as the number of input data decreases in contrast to that of traditional methods without the pre-treatment. The model provides a practical tool for predicting the wellbore permeability in a heterogeneous reservoir where it is difficult to establish a functional relationship between permeability and well log.
Expression Profile Analysis and Image Observation of miRNA in Serum of Patients with Obstructive Sleep Apnea-Hypopnea Syndrome

The expression profile and image observation of miRNA in serum of patients with obstructive sleep apnea-hypopnea syndrome were investigated. Bioinformatics methods were used to explore the molecular mechanism of obstructive sleep apnea-hypopnea syndrome (OSAHS)-related hypertension and explore the differentially expressed core miRNAs and regulatory factors, providing a theoretical basis for seeking molecular targets for clinical diagnosis and treatment. The miRNA datasets of patients with OSAHS and those with hypertension were downloaded from the public database to obtain differentially expressed miRNAs and explore the biological processes and pathways involved in the target genes. The core miRNAs and competitive endogenous RNA (ceRNA) transcription factors (TFs) were obtained by database mining and Cytoscape network analysis. The results showed that 2,579 differentially expressed miRNAs were obtained from the GSE112093 dataset. Seven upregulated miRNAs (hsa-miR-7107-5p, hsa-miR-7110-5p, hsa-miR-595, hsa-miR-1268b, hsa-miR-3064-5p, hsa-miR-68565p, and hsa-miR-1180-3p) and one downregulated miRNA (hsa-miR-22-3p) were obtained from the GSE112093 dataset. It is proved that hsa-miR-22-3p, hsa-miR-595, hsa-miR-6856-5pKcnq1ot1, neat1, Tsix, ERG, kdm2b, and Runx1 may be involved in the pathogenesis of OSAHS-related hypertension, which provided a theoretical basis for the mechanism research and clinical treatment of OSAHS.
Transmission Line Mode Response of a Multiconductor Cable in a Transient Electromagnetic Field

This paper describes a technique for obtaining the induced worst case currents on individual wires of a multiconductor cable as a result of a transient electromagnetic radiation field. The technique involved a development of the expression for the induced current in matrix form where the mutual coupling terms and the other cable currents are the pertinent parameters. A worst case solution results from the assumption of maximum coupling orientation of the individual wires. A short example and some test results are presented. The test results show wave shapes for inductive and capacitive coupling. The solution for the individual wire current due to a transient electromagnetic field is important, since it will greatly reduce the required number of cable measurements and will allow the development of improved shielding techniques.
The complete mitochondrial genome of the marine feather duster, Bispira melanostigma (Annelida: Sabellidae)

Abstract The marine feather duster, Bispira melanostigma (Schmarda, 1861), is a tube-dwelling annelid that contributes to ecological and biogeochemical processes in benthic communities. Due to the lack of scientific data, B. melanostigma is often difficult to distinguish from other species of marine worms through morphological characteristics alone. In this study, we report the complete mitochondrial genome of Bispira melanostigma. The complete mitogenome contained 20,624 bp length with a total of 13 protein-encoding genes, 21 tRNA, and 2 rRNA genes. Phylogenetic analysis of the complete mitochondrial DNA of B.melanostigma can aid in the understanding of evolutionary relationships within Sabellidae.
Phase (delay) equalization of recursive digital filters

The purpose of this paper is to present a quasi-analytical procedure for designing equalized recursive digital filters satisfying prescribed amplitude specifications. The design procedure is based on the generation of a class of sampled-data polynomials designed as the arbitrary phase polynomials. The generation has been carried out by using Lagrange interpolation. The proposed procedure is applied to the design of low-pass and high-pass elliptic recursive digital niters. The procedure is simple and can be implemented by using a desk-top microcomputer. A BASIC program for the low-pass case was developed.
Influence of minimum quantity lubrication parameters on tool wear and surface roughness in milling of forged steel

The minimum quantity of lubrication (MQL) technique is becoming increasingly more popular due to the safety of environment. Moreover, MQL technique not only leads to economical benefits by way of saving lubricant costs but also presents better machinability. However, the effect of MQL parameters on machining is still not clear, which needs to be overcome. In this paper, the effect of different modes of lubrication, i.e., conventional way using flushing, dry cutting and using the minimum quantity lubrication (MQL) technique on the machinability in end milling of a forged steel (50CrMnMo), is investigated. The influence of MQL parameters on tool wear and surface roughness is also discussed. MQL parameters include nozzle direction in relation to feed direction, nozzle elevation angle, distance from the nozzle tip to the cutting zone, lubricant flow rate and air pressure. The investigation results show that MQL technique lowers the tool wear and surface roughness values compared with that of conventional flood cutting fluid supply and dry cutting conditions. Based on the investigations of chip morphology and color, MQL technique reduces the cutting temperature to some extent. The relative nozzle-feed position at 120°, the angle elevation of 60° and distance from nozzle tip to cutting zone at 20 mm provide the prolonged tool life and reduced surface roughness values. This fact is due to the oil mists can penetrate in the inner zones of the tool edges in a very efficient way. Improvement in tool life and surface finish could be achieved utilizing higher oil flow rate and higher compressed air pressure. Moreover, oil flow rate increased from 43.8 mL/h to 58.4 mL/h leads to a small decrease of flank wear, but it is not very significant. The results obtained in this paper can be used to determine optimal conditions for milling of forged steel under MQL conditions.
A single‐switch high‐gain DC–DC converter for photovoltaic applications

This article presents a high‐gain DC–DC converter consisting of a quadratic boost converter and a voltage multiplier, which helps to lift up the voltage gain. The gain will be further enhanced by increasing the turn's ratio of the coupled inductor. The key features include ultrahigh gain, low voltage stress across switching devices, low input current ripple, and hence, it is preferably suitable for renewable energy applications. A passive clamp lowers the voltage stress across MOSFET, so allowing switch with lower Rds(on) reduces the system cost. Besides this, input inductor makes current continuous and reduces input current ripple. The reverse recovery problem of diodes also gets diminished with the usage of leakage energy of the coupled inductor. The operating principle with different modes of operation is also explained. Zero current switching (ZCS) turn‐on is achieved for power switch, and ZCS turn‐off is achieved for diodes, which helps to reduce the switching losses. This improves the overall system efficiency. A 250‐W prototype is built up to validate the converter.
Genome-Wide DNA Methylation Signatures Predict the Early Asymptomatic Doxorubicin-Induced Cardiotoxicity in Breast Cancer

Simple Summary This study examined whether the DNA methylation state of peripheral blood mononuclear cells (PBMCs) could predict cardiotoxicity caused by doxorubicin (DOX)-based chemotherapy in breast cancer patients. The results showed a significant difference in the pattern of DNA methylation of PBMCs associated with a risk of cardiotoxicity. These preliminary findings have the potential to further the goal of personalized medicine and tailor the treatment of breast cancer with DOX-based chemotherapy to reduce the toxicity to the heart. Abstract Chemotherapy with doxorubicin (DOX) may cause unpredictable cardiotoxicity. This study aimed to determine whether the methylation signature of peripheral blood mononuclear cells (PBMCs) prior to and after the first cycle of DOX-based chemotherapy could predict the risk of cardiotoxicity in breast cancer patients. Cardiotoxicity was defined as a decrease in left ventricular ejection fraction (LVEF) by >10%. DNA methylation of PBMCs from 9 patients with abnormal LVEF and 10 patients with normal LVEF were examined using Infinium HumanMethylation450 BeadChip. We have identified 14,883 differentially methylated CpGs at baseline and 18,718 CpGs after the first cycle of chemotherapy, which significantly correlated with LVEF status. Significant differentially methylated regions (DMRs) were found in the promoter and the gene body of SLFN12, IRF6 and RNF39 in patients with abnormal LVEF. The pathway analysis found enrichment for regulation of transcription, mRNA splicing, pathways in cancer and ErbB2/4 signaling. The preliminary results from this study showed that the DNA methylation profile of PBMCs may predict the risk of DOX-induced cardiotoxicity prior to chemotherapy. Further studies with larger cohorts of patients are needed to confirm these findings.
A positioning theory method for culture analysis and development

Positioning theory has been used in a range of research to understand the social order or culture that affects how various phenomena occurs. Here a practical positioning theory model is presented that is based on previous research using positioning theory. Various forms and procedures are presented and explained. It is put forward that this model can be applied to social situations as a thought framework to enable greater understanding. It has been shown (Boxer 2003a, 2003b, 2002, 2001) that by breaking culture into four components - rights, duties, morals and actions - the culture can be understood in terms of what people can affect. A gap can be determined through defining the current situation in terms of these four components and then comparing this definition with a desired culture. That gap becomes the objective for cultural change. As change is being implemented its success can be measured through the same method. A manager has an obligation to create a culture conductive to achieving their goals. As an analytical tool, this offers an empirical view of an organisation, which will enable alignment of the culture with organisational objectives. Managers will benefit from the understanding they gain of their current culture and their progress towards their desired culture. The effectiveness of this model may vary due to contextual differences.
Discovery of Octahydroisoindolone as a Scaffold for the Selective Inhibition of Chitinase B1 from Aspergillus fumigatus: In Silico Drug Design Studies

Chitinases represent an alternative therapeutic target for opportunistic invasive mycosis since they are necessary for fungal cell wall remodeling. This study presents the design of new chitinase inhibitors from a known hydrolysis intermediate. Firstly, a bioinformatic analysis of Aspergillus fumigatus chitinase B1 (AfChiB1) and chitotriosidase (CHIT1) by length and conservation was done to obtain consensus sequences, and molecular homology models of fungi and human chitinases were built to determine their structural differences. We explored the octahydroisoindolone scaffold as a potential new antifungal series by means of its structural and electronic features. Therefore, we evaluated several synthesis-safe octahydroisoindolone derivatives by molecular docking and evaluated their AfChiB1 interaction profile. Additionally, compounds with the best interaction profile (1–5) were docked within the CHIT1 catalytic site to evaluate their selectivity over AfChiB1. Furthermore, we considered the interaction energy (MolDock score) and a lipophilic parameter (aLogP) for the selection of the best candidates. Based on these descriptors, we constructed a mathematical model for the IC50 prediction of our candidates (60–200 μM), using experimental known inhibitors of AfChiB1. As a final step, ADME characteristics were obtained for all the candidates, showing that 5 is our best designed hit, which possesses the best pharmacodynamic and pharmacokinetic character.
Taxonomy-Based Pruning in Generalized Frequent Itemsets Mining

The original purpose of data mining is for analysis of supermarket transaction data. Now with the rapid development in business, industry and science, data mining is used in lots of domains, so mining interesting information from large database becomes more important. Data mining includes two main parts: frequent itemsets mining and association rules mining. And frequent itemsets mining plays an essential role between them. Our thesis is focused on frequent itemsets mining. Previous studies on frequent itemsets mining is at single or multiple concept level, however, mining frequent itemsets at flexible multiple concept level may help finding more specific and useful information from huge data. In this thesis, four methods are introduced for mining frequent itemsets at flexible multiple level by extension of Apriori and Eclat algorithms. We also implement two algorithms for frequent pairs mining. We draw some conclusions about which method is suitable for which distributions of data.
Monte Carlo harmonic-balance and drift-diffusion harmonic-balance analyses of 100-600 GHz Schottky barrier varactor frequency multipliers

To date, high frequency multipliers have been designed and analyzed using harmonic-balance codes incorporating equivalent circuit models for the diodes. These codes, however, are unable to accurately predict circuit performance at frequencies above 100 GHz and do not allow a means for studying the physics of electron transport. In order to analyze these high frequency Schottky doublers, a novel harmonic-balance technique has been integrated into a drift-diffusion numerical simulator and, for the first time, a Monte Carlo numerical device simulator. The unification of the numerical device simulator with the harmonic-balance algorithm allows for the self-consistent study of electron transport phenomena as well as the study of device performance in a given circuit. These combined simulators are tested against experimental data and an equivalent circuit model harmonic-balance approach, and yield superior accuracy with respect to the experimental data.
Part 2: Microseismic aspects of the Basel 1 geothermal reservoir

The generation of an efficient hydraulic subsurface heat exchanger system is crucial for economic production of electricity and heat from an Enhanced Geothermal System. The circulation of water at sufficiently low flow impedances through natural discontinuities typically requires hydraulic stimulation to improve the hydraulic properties of the naturally fractured rock mass. This fluid injection process induces shearing on favourably oriented fracture patches which results in an increase of hydraulic conductivity due to self propping effects. The rupture procedure is accompanied by a stress release that causes the emission of seismic energy. Monitoring these so called microseismic events provides valuable information with respect to the spatial and temporal reservoir growth, the reservoir geometry and assists in the optimum targeting of subsequent geothermal wells. A sophisticated microseismic network array has been realized with a focus on appropriate network sensitivity, hypocenter location accuracy and operational reliability. Absolute event hypocenters were mapped in real-time applying an automatic routine for event detection, P- and S-wave onset time determination and an exhaustive grid search for event location. In parallel to this autoprocessing routine the auto picked traveltimes were visually checked and the events relocated where neccessary. Within the time frame 2 nd to 15 th December 2006 covering a hydraulic injection phase from 2 nd to 8 th December, some 13600 events were detected. Applying tight and consistent location criteria reliable event locations were obtained for 3146 events, the location error of which was of the order of 100 m. The overall image of the seismically active volume displays a subvertical disc like structure trending about N159°E and a single offsetting branch with an azimuth of N100°E. The dominant NNW-SSE reservoir trend corresponds with the direction of SHmax (N144°±14°E) and the predominant azimuth of natural discontinuities (N140°-170°E). In a post processing step the microseismic data set have been relocated using a relative location method (Waldhauser and Ellsworth, 2000) which enabled the mapping of small scale seismically active features. These clusters of coherent events form predominantly elongated oblate ellipsoid shaped structures of about 100 m to several 100 m length. The location error in between relative located events is typically in the order of < 10 m. The physical meaning of these mapped structures is still subject to ongoing investigations. Assuming the validity of the double couple model, the fault plane solutions for a range of events with varying magnitudes were carefully analysed based on Pwave first motion polarity observations. The interpreted focal mechanisms indicate a strike slip dominated stress regime which is in line with independent
Vibro-acoustic method of transformer clamping pressure monitoring

This paper presents a vibro-acoustic method of on-line monitoring of a transformer core and winding clamping pressure. The method based on the dependence of oscillating frequencies spectra on the clamping force allows to distinguish between the core and the winding clamping pressure drop. Special software was developed for its practical application. Examples of practical application are given.