Miracle-dz/UniFAR-FTUs huggingface dataset:
Probing the Skin–Brain Axis: New Vistas Using Mouse Models

Inflammatory diseases of the skin, including atopic dermatitis and psoriasis, have gained increasing attention with rising incidences in developed countries over the past decades. While bodily properties, such as immunological responses of the skin, have been described in some detail, interactions with the brain via different routes are less well studied. The suggested routes of the skin–brain axis comprise the immune system, HPA axis, and the peripheral and central nervous system, including microglia responses and structural changes. They provide starting points to investigate the molecular mechanisms of neuropsychiatric comorbidities in AD and psoriasis. To this end, mouse models exist for AD and psoriasis that could be tested for relevant behavioral entities. In this review, we provide an overview of the current mouse models and assays. By combining an extensive behavioral characterization and state-of-the-art genetic interventions with the investigation of underlying molecular pathways, insights into the mechanisms of the skin–brain axis in inflammatory cutaneous diseases are examined, which will spark further research in humans and drive the development of novel therapeutic strategies.
Endoscopic versus microscopic approach for management of pituitary tumors

Background: Pituitary tumors are most commonly approached through the transsphenoidal approach, and tumor resection is most often performed using the operating microscope. More recently the endoscope has been introduced for use either as an adjunct to or in lieu of the microscope. Both the microscopic and endoscopic transsphenoidal approaches to pituitary tumors allow safe and effective tumor resection. This study showed the advantages and disadvantages of the pure transsphenoidal endoscopic approach compared with the standard microscopic approach. Patients and methods: This is a retrospective study of forty patients presented with pituitary macroadenoma including both sexes, with ranging age from 20-50 years. These patients presented to the neurosurgery department of Al-Azhar university hospitals during the period from October 2010 to October 2013.The Patients were divided into two groups: The 1group; included 20 patients, who subjected to endoscopic endonasal transsphenoidal pituitary surgery. The 2 group; included 20 patients, were subjected to classic microscopic sublabial transsphenoidal pituitary surgery. Results: This comparative study was including two groups; the first group representing twenty patients with pituitary tumors who operated using endoscopic transsphenoidal technique; and the second group showed twenty patients with pituitary tumors were operated using the microscopic sublabial transsphenoidal technique. The patients in the first group included 5 males (25%) and 15 females (75%) and in the second group included 8 males (40%) and 12 females (60%) with age ranging from (20-50) years (median: 35 years). They are presented by one or more symptoms. The commonest symptoms were headache (92.5%), followed by endocrinal symptoms (80%), then visual symptoms (75%). In the first group total removal of the lesion was achieved in 10 cases (50%), while subtotal removal was achieved in 8 cases(40%),and partial removal was achieved in 2cases (10%). While in the second group total removal was achieved in 5 cases (25%), subtotal removal was achieved in 7 cases (35%) and partial removal was achieved in 8 cases (40%). Conclusion: The pure endoscopic approach is a safe, effective approach to sellar region tumors that offers several advantages over the microscopic approach. It provides an excellent wide-angle and magnified view of the operative anatomy, and although it requires more anatomical exposure it remains within the group of minimally invasive approaches to the sella. High disease control rates and low rates of complications are some of the most important points related to the technique. Some of the factors related to the success of endoscopic surgery are lesion size, suprasellar/ parasellar extension, and the degree of sella floor erosion. [Mahmoud Farid. Endoscopic versus microscopic approach for management of pituitary tumors. J Am Sci 2015;11(1):7-14]. (ISSN: 1545-1003). http://www.jofamericanscience. org. 2
Control of Wireless Power Transfer System for Dynamic Charging of Electric Vehicle

In order to limit the production of pollutant gases, the transportation sector, both public and private, has turned its attention to Electric Vehicles (EVs). The most important barrier to commercializing and spreading EVs are the issues regarding the battery. The batteries are heavy, bulky, expensive, and have a limited lifetime. Furthermore, frequent charging and limited operating range due to the low energy density are other obstacles to developing EVs worldwide. Dynamic Wireless Power Transfer (WPT) is a possible solution in order to solve the problems related to the battery. In this solution, the battery of the EV can be charged when the vehicle is in motion. In this kind of charging system, the transmitter coils are embedded into the ground and the receiver coil is installed underneath the vehicle. Through a sufficient charging infrastructure large enough to charge the electric vehicle during driving, the size of the battery onboard can be reduced and the driving range of the EV can be extended. EV and without any establishment of the communication between vehicle and ground, even in the case of lateral misalignment or variations of the air-gap. Subsequently, the complete simulation of the system in static and dynamic charging conditions is performed and the operation in different charging conditions such a variation of the operating frequency, power demand, lateral misalignment, vehicle speed, and air-gap, is studied. The procedure for the construction of the charging lane with the development of the coils, the embedding procedure and implementation of the power electronic converter is presented.
Remote teaching in times of social distancing: a study in the accounting and actuarial sciences courses

Purpose: Considering the imposed social isolation measures to contain the spread of the Sars-Cov-2 virus, the cause of COVID-19 pandemic, the in-person classes started to be held remotely. Those measures had an impact on education, mainly because they had to be adopted quickly, with no time for preparation. In our current study, we investigate how remote teaching has been occurring in the undergraduate courses of Accounting and Actuarial Sciences at a Public Higher Education Institution (PHEI), in times of social distancing. Methodology: An e-survey was carried out with teachers and students, in order to obtain information on the subject. The collected data were processed using statistical techniques to generate the results. Results: It came across that the studied PHEI did not have resources such as a Flipped classroom, Digital Whiteboard or any other technological tools to support remote classes, since the remote teaching modality became a need during the COVID-19 pandemic. The PHEI launched, via public notices, programs for digital inclusion in order to acquire mobile data and equipment, such as computers/smartphones/tablets for students; however, only few of the students could have access to those resources. Contributions of the Study: Our research results contribute to the state-of-the-art regarding undergraduate courses, by investigating their evolution towards remote learning. Such contributions provide information and knowledge on this subject to the national scientific literature, and give support and guidance to other courses offered by public and/or private higher education institutions.
Flow-induced vibration characteristics of the U-type Coriolis mass flowmeter with liquid hydrogen

Compared with liquid nitrogen (LN2) and water, the density of liquid hydrogen (LH2) is more than one order of magnitude smaller, which leads to significantly different flow-induced vibration characteristics in the Coriolis mass flowmeter (CMF). Based on the Euler beam theory, the complex set of equations of fluid-solid interactions for the U-type pipe Coriolis flowmeter with LH2 is solved. The calculation results are firstly validated by comparing the dimensionless frequency, displacement, and twist mode shape with the theoretical and experimental results in the other publications with water and kerosene as the working fluids. Then, the results of dimensionless frequency, phase difference, and time lag for LH2 are compared with those for LN2 and water, and the effects of the dimensionless flow velocity, sensor position, and the radius of the curved pipe are analyzed in detail for LH2. Results show that the time lag of LH2 is an order of magnitude smaller than that for LN2 or water. The excitation frequency for LH2 is much larger than that for LN2. Effects of geometric parameters on the time lag are also analyzed for the three fluids and the results contribute to the design optimization of a CMF for LH2.
Advanced Practice Registered Nurse Transition to Practice in the Long-Term Care Setting: An Ethnography

Advanced practice registered nurses are successful in improving quality outcomes and filling provider care gaps in long-term care. However, little is known about the nurse’s transition to practice in this setting. A 12-month ethnography was conducted via participant-observation with nine advanced practice registered nurses in five long-term care facilities to understand practice environment influence on the nurses’ transition and on the reciprocal influence of the nurse on the practice environment. Transition was fraught with uncertainty as documented by five themes: where’s my authority, institutional acceptance, personal role fulfillment, provider relationships, and individual versus organizational care. These findings suggest that transition in this setting is complex, characterized by insecurity whether the individual is new to advanced practice or experienced. Transition in long-term care could be strengthened by formal programs that include clinical practice, reconceived mentorship for advanced practice registered nurses, and education designed to improve comfort and expertise with indirect care.
BIOCHEMICAL CHANGES IN SOME TABLE GRAPE CULTIVARS THROUGHOUT THE RIPENING PROCESS

This study was conducted to investigate the biochemical changes observed throughout the ripening process from veraison to harvest periods of 13 table grape cultivars of Vitis vinifera L. species. Present findings revealed that total acidity, total phenolics and total antioxidant capacity of the grape cultivars decreased and water soluble dry matter (WSDM) content, must pH and total anthocyanins increased throughout the ripening process. In harvest period, water soluble dry matter (WSDM) contents varied between 17.0% (‘Trakya İlkeren’ and ‘Şilfoni cultivars’) and 21.6% (‘Kureyş’ cultivar); total acidity values varied between 0.42 g l–1 (Tekirdağ Seedless cultivar) and 1.26 g l–1 (‘Kızılatım’ cultivar); must pH values varied between 2.58 (‘Köhnü’ cultivar) and 3.29 (‘Trakya İlkeren’ cultivar); ripening index values varied between 15.60 (‘Şilfoni’ cultivar) and 41.90 (‘Tekirdağ Seedless’ cultivar); total phenolics varied between 723.5 µg GAE g–1 (‘Mazırım’ cultivar) and 2657 µg GAE g–1 (‘Banazı Karası’ cultivar); total antioxidant capacities varied between 4.27 µmol TE g–1 (‘Mazırım’ cultivar) and 8.21 µmol TE g–1 (‘Köhnü’ cultivar); total anthocyanins varied between 32.3 malvidin-3-o-glikozit µg g–1 (‘Kızılatım’ cultivar) and 205.2 malvidin-3-o-glikozit µg g–1 (‘Banazı Karası’ cultivar). Berry skin colors strongly correlated with total phenolics (R2 = 0.9376) and total antioxidant capacity (R2 = 0.8296).
Reflections on statistical significance and practical importance in information systems research

This is an invited commentary on a paper by Sen et al. (forthcoming). I explain how their paper provides a useful reminder of the need to communicate the practical importance of statistical findings more effectively and more often. I also explain how their recommendations address just a small piece of the issue of practical importance. I describe how we must keep the whole issue in mind and I provide examples from my editorial role at MIS Quarterly.
An Unconventional Shape Memory Alloy Low-Power Ratchet for Reconfiguring the Polarization of a Moiré Pattern-Based Antenna

In this article, a novel polarization reconfigurable antenna based on the Moiré effect is proposed. The presented design exploits substantial changes in the overlapped Moiré patterns to minimize the needed actuation for antenna reconfiguration. The novel antenna design is based on stacking two circular FR4 substrates on top of a truncated edge rectangular patch antenna. The top layers of both the substrates are milled into horizontal stripes forming the Moiré patterns. One of these substrates is fixed with respect to the antenna, while the second one rotates with respect to the fixed substrate. Upon rotation, these stripes from the two substrates overlap in pattern, which shapes the antenna. As a result, the antenna design is capable of switching its polarization scheme between vertical, horizontal, and circular with left-hand orientation. In addition, the Moiré patterns can also enhance the directivity and gain of the proposed antenna. The reconfiguration’s mechanical actuation is achieved via a nontraditional ratchet mechanism that uses shape memory alloys (SMAs). This realized actuation system is fast, flexible in its positioning, has low energy expenditure, and minimizes interference with antenna operation. An antenna prototype is fabricated and tested where measured results match the simulated performance.
Control and Bio-Inspired Motion Estimation of a Vision-Guided Quadrotor

This work aims to establish a heterogeneous air-ground multi-robot system consisting of a vision-guided quadrotor and a mobile ground robot in order to study various aspects of a flying system. The substantial contributions of this work are a novel system configuration, significant improvements in quadrotor pose/motion estimation in terms of high accuracy and high sample rate, enhanced control performance in relation to effectiveness and integrity, as well as advanced exploration in insect-inspired flight control. The performance of the autonomous quadrotor is extensively evaluated in simulations and real-time experiments. The contributions significantly advance the state of the art in motion estimation and control of a vision-guided autonomous flying system and serve as a signpost for future research.
Intersection Complexity and Its Influence on Human Drivers

As mixed traffic between automated vehicles and human drivers in inner city becomes more prevalent in the near future understanding and predicting drivers’ behavior is important. Additionally, there is a wide variety of inner city intersections. They can differ greatly in traffic density, visibility, number of objects and many more aspects. This difference in complexity has an influence on the behavior of human drivers at intersections. To further understand the effect of complexity we conducted a naturalistic driving field study in inner city traffic with 34 participants. We focused on unsignalized intersections because there is a greater range of possibly ambiguous situations at such intersections than compared to e.g. an intersection regulated by traffic lights. Features describing the behavior (commit distance, drop in velocity and the minimal velocity) are extracted from the driven trajectories. Additionally, we define intersection complexity by several features describing an intersection. These features include both the static (street, visible and driveable width, the visibility of the other streets and the number of trees) and the dynamic environment (entry location and turning direction, numbers of vehicles, vehicles with interaction, vehicles with priority, vehicles having to yield and pedestrians). Based on those we show that the entry location and the turning direction have a significant effect on the behavior features. Additionally, we show that the typical behavior of human drivers can be predicted by the features describing an intersection’s complexity. Finally, the feature set is reduced in dimensionality for a more condensed intersection description. For that we test reduced feature sets as well as feature sets from an autoencoder and show that prediction is feasible with them as well.
What does gross national happiness really measure? An immersive observation in Lamshey, Bhutan

The purpose of this paper is to investigate the relationship between the Gross National Happiness indicator and the actual lifestyle of the people of Bhutan. Gross National Happiness is a macroeconomic indicator calculated in Bhutan. It was constructed in contrast to the Gross Domestic Product. Gross National Happiness is designed to guide the country's public policies. Using visual methods in anthropology, this study proposes an immersion in Lamshey, a village in Bhutan. The daily life of the inhabitants is then observed and analyzed with the way gross national happiness is measured. The sociology of quantification provides a framework for analysis that reveals important and new implications. Indeed, to bring together the experience of happiness as it is lived by the Bhutanese, it will be appropriate to distinguish three complementary "Gross National Happiness", according to whether it is measured, lived, or in its ethical dimension.
The Impact of Hydropower Energy in Malaysia Under the EKC Hypothesis: Evidence From Quantile ARDL Approach

The present study investigates the impact of economic growth, hydropower generation, and urbanization on Malaysia’s CO2 emissions. This study applies Quantile Autoregressive Lagged (QARDL) technique for the period of 1965Q1 to 2018Q4. The Granger-causality in quantiles is applied to confirm the causal nexus among the modeled variables. The outcomes demonstrate that hydropower generation decreases the detrimental effects of CO2 emissions at the range of high quantile levels. Furthermore, urbanization, except for higher quantiles, exhibits negative impacts on CO2 emissions. Also, the QARDL coefficients confirm the presence of the Environmental Kuznets Curve hypothesis from median to higher quantiles. Besides, the Granger-causality test confirms the two-way causality among CO2 emissions and hydropower generation in Malaysia’s economy and the same for the other series. The policymakers should enhance the market attractiveness of hydropower generation projects through incentives for the investors.
Calculation of Aortic VAlve and LVOT Areas by a Modified Continuity Equation Using Different Echocardiography Methods: The CAVALIER Study

Background: The area of the left ventricular outflow tract (ALVOT) represents a major component of the continuity equation (CE), which is, i.a. , crucial to calculate the aortic valve (AV) area (AAV). The ALVOT is typically calculated using 2D echo assessments as the measured anterior–posterior (a/p) extension, assuming a round LVOT base. Anatomically, however, usually an elliptical shape of the LVOT base is present, with the long diameter extending from the medial–lateral axis (m/l), which is not recognized by two-dimensional (2D) echocardiography. Objective: We aimed to compare standard and three-dimensional (3D)-echocardiography-derived ALVOT calculation and its use in a standard CE (CEstd) and a modified CE (CEmod) to calculate the AAV vs. computed tomography (CT) multi-planar reconstruction (MPR) measurements of the anatomical ALVOT, and AAV, respectively. Methods: Patients were selected if 3D transthoracic echocardiography (TTE), 3D transesophageal echocardiography (TEE), and cardiac CT were all performed, and imaging quality was adequate. The ALVOT was assessed using 2D calculation, (a/p only), 3D-volume MPR, and 3D-biplane calculation (a/p and m/l). AAV was measured using both CEstd and CEmod, and 3D-volume MPR. Data were compared to corresponding CT analyses. Results: From 2017 to 2018, 107 consecutive patients with complete and adequate imaging data were included. The calculated ALVOT was smaller when assessed by 2D- compared to both 3D-volume MPR and 3D-biplane calculation. Calculated AAV was correspondingly smaller in CEstd compared to CEmod or 3D-volume MPR. The ALVOT and AAV, using data from 3D echocardiography, highly correlated and were congruent with corresponding measurements in CT. Conclusion: Due to the elliptic shape of the LVOT, use of measurements and calculations based on 2D echocardiography systematically underestimates the ALVOT and dependent areas, such as the AAV. Anatomically correct assessment can be achieved using 3D echocardiography and adapted calculations, such as CEmod.
Empirical Analysis of Multi-factor Stock Selection Model Based on Weight Assignment of Momentum and Discrete Degree

Through the stock selection of a large number of literature, we found that factors contribute differently at different market styles or stages, and the factor weight is different. Therefore, in this paper, the factors were preliminarily screened by IC mean and IR equal weight scoring method and T test, and then the screened factors were tested by correlation test and sorting method to obtain the final factors. After five methods, such as factor equal weight, momentum and dispersion comprehensive average weight, were tested and compared, we found that the method of momentum and dispersion comprehensive average weight on the effect of the stock selection is more excellent than other methods, so we chose the momentum and discrete degree of comprehensive weighted average approach to dynamic weighting of each stock, the last stock through empowerment scoring method selection. In this way, the speed of market change and the impact of industry on factors are better considered, and the te-test effect is better.
The Effect of Takeovers on the Performance of Acquirers in Australia Based on The Economic Value Added Method

In theory, the acquisition is a fast way to expand a business or enter a new market, so the bidder company should perform better after the takeover. Research has been conducted on whether the performance of the bidder company can be improved after the acquisition, but the empirical results do not fully support the theory. Moreover, the studies on takeover activities in Australia are relatively rare. This paper examines bidding companies' performance in public acquisitions in Australia in 2017 based on EVA accounting methodology. We collect the data from 2013 to 2021 of the acquirer companies that bought the target companies in 2017 and calculate the acquirer companies' performance by EVA. We then compare their EVA before and after the acquisition and analyze the effect of the acquisition, demonstrating the average EVA experienced a slight rise in the three years after the acquisition. Two companies had a positive EVA after the acquisition, while the EVA of all the companies were negative before.
Clean synthesis of isoprene with six E. coli engineering strains

Isoprene is one of the most important platform chemicals containing conjugated double bonds and utilized as the precursor material of varieties of chemical raw materials. Currently, isoprene is mostly produced by petroleum smelting, which produces CO2 and some pollution. In that case, the clean production method of isoprene is still the focus of current research. Isoprene synthase (IspS) catalyzes isoprene formation from a metabolic intermediate DMAPP. The expression level and enzyme activity of IspS from different strains affect the amount of isoprene production. In this study, six IspS protein sequences were obtained by searching literatures and NCBI database based on the phylogenetic analysis. We analysed the conservation of their catalytic structures and constructed pBAD expression frameworks for them. The isoprene synthesis systems in E. coli were built and worked in the best induction condition predicted in our study. We used toluene to collect the isoprene produced in the system detected and compared the productivity of each strain. Our results show that the production in cells were 1.55-5.51 μg/L/h.