Miracle-dz/UniFAR-FTUs huggingface dataset:
CONFLITO COGNITIVO NA DECISÃO ESTRATÉGICA DE EQUIPES DE DIREÇÃO EM PEQUENAS EMPRESAS

Purpose: The objective of this article is to explain how the cognitive conflict happens and what are its contributions in the decision-making processes of management teams in small enterprises (SE). Originality/value: Although SEs are important and numerous, the cognitive conflict in their management team and the strategic decision making of this team are understudied. This article helps to feel this gap with contributions and implications which are helpful for research and practice related to those themes. Design/methodology/approach: The descriptive methodological approach was adopted based on qualitative methods and multicase study (Eisenhardt, 1989). Data were collected with interviews and analyzed with within and cross case procedures according to Miles and Huberman’s (1994) recommendations. Four cases of SE were studied. Findings: The strategic decision processes were considerably determined by cognitive conflicts. Such conflicts questioned decision possibilities and highlighted aspects related to intuition and improvisation, both normally useful and present in the strategic decision processes of SE. Cognitive conflict inhibits improvisation because its occurrence creates useful questionings in decision making preparation. Those questionings generated deepness in discussion and analysis for decision making in the studied SEs.
chronic myeloid leukemia: 2013 European LeukemiaNet recommendations for the management of

Goldman and Rüdiger Hehlmann Saußele, Charles Schiffer, Richard Silver, Bengt Simonsson, Juan-Luis Steegmann, John M. Niederwieser, Fabrizio Pane, Jerald P. Radich, Philippe Rousselot, Giuseppe Saglio, Susanne Jeffrey H. Lipton, François-Xavier Mahon, Giovanni Martinelli, Jiri Mayer, Martin C. Müller, Dietger Hjorth-Hansen, Timothy P. Hughes, Hagop M. Kantarjian, Dong-Wook Kim, Richard A. Larson, Jane F. Apperley, Francisco Cervantes, Richard E. Clark, Jorge E. Cortes, François Guilhot, Henrik Michele Baccarani, Michael W. Deininger, Gianantonio Rosti, Andreas Hochhaus, Simona Soverini, chronic myeloid leukemia: 2013 European LeukemiaNet recommendations for the management of
Perverse effects of two-tier wage bargaining structures

Debate over labor market flexibility focuses mainly on firing costs, while largely ignoring wage determination and the need for collective bargaining reform. Most countries affected by the euro debt crisis have two-tier bargaining structures in which plant-level bargaining supplements national or industrywide (multi-employer) agreements, taking the pay agreement established at the multi-employer level as a floor. Two-tier structures were intended to link pay more closely to productivity and to allow wages to adjust downward during economic downturns, while preventing excessive earning dispersion. However, these structures seem to fail precisely on these grounds.
Seasonality in onshore normalized wind profiles above the surface layer

Abstract. This work aims to study the seasonal difference in normalized wind speed above the surface layer as it is observed at the 160 m high mast at the coastal site Hovsore at winds from the sea (westerly). Normalized and stability averaged wind speeds above the surface layer are observed to be 20 to 50% larger in the winter/spring seasons compared to the summer/autumn seasons at winds from west within the same atmospheric stability class. A method combining the mesoscale model, COAMPS, and observations of the surface stability of the marine boundary layer is presented. The objective of the method is to reconstruct the seasonal signal in normalized wind speed and identify the physical process behind. The method proved reasonably successful in capturing the relative difference in wind speed between seasons, indicating that the simulated physical processes are likely candidates to the observed seasonal signal in normalized wind speed.
Embedding theorems and quasi-linear elliptic boundary value problems for unbounded domains

The Sobolev-Kondrachov embedding and compactness theorems are extended to cover general unbounded domains, by introducing appropriate weighted Lp norms. These results are then applied to the Dirichlet problem for quasi-linear elliptic partial differential equations and isoperimetric variational problems defined on general unbounded domains in R".
A novel syndrome of abnormal striatum and congenital cataract : evidence for linkage to chromosomes 11

We report a consanguineous family of three girls and one boy affected with a novel syndrome involving the lens and the basal ganglia. The phenotype is strikingly similar between affected siblings with cognitive impairment, attention deficit hyperactivity disorder (ADHD), microcephaly, growth retardation, congenital cataract, and dystonia. The magnetic resonance imaging showed unusual pattern of swelling of the caudate heads and thinning of the putamina with severe degree of hypometabolism on the [18F] deoxyglucose positron emission tomography. Furthermore, the clinical assessment provides the evidence that the neurological phenotype is very slowly progressive. We utilized the 10K single-nucleotide polymorphism (SNP) microarray genotyping for linkage analysis. Genome-wide scan indicated a 45.9-Mb region with a 4.2353 logarithm of the odds score on chromosome 11. Affymetrix genome-wide human SNP array 6.0 assay did not show any gross chromosomal abnormality. Targeted sequencing of two candidate genes within the linkage interval (PAX6 and B3GALTL) as well as mtDNA genome sequencing did not reveal any putative mutations.
Assessing consistency between EOS MLS and ECMWF analyzed and forecast estimates of cloud ice

Cloud ice water content (IWC) from MLS retrievals and ECMWF analyses and forecasts are compared for August 2004 to July 2005. ECMWF data are sampled along MLS tracks and filtered according to MLS sensitivity. At 147 hPa, there is good spatial agreement with the analyses biased high by 10%. Over landmasses, the analyses are biased low up to 50%. This underestimation grows in the forecasts, with a 40% reduction by day 10. At 215 hPa, the analyses are biased low by 10–60%. However, at this level the forecast IWC undergoes little change. These biases, in conjunction with those in precipitation and top of the atmosphere radiative fluxes, along with consideration of the changes in vertical velocity, cumulus cloud mass flux and cloud top detrainment, indicates a systematic reduction of the modeled deep convection over the warm pool in conjunction with a weakened large‐scale circulation and enhanced upper‐level vertical stratification.
MUC 4 stabilizes HER 2 expression and maintains the cancer stem cell population in ovarian cancer cells

Background: Recent evidence has suggested that the capability of cancer to grow, propagate and relapse after therapy is dependent on a small subset of the cell population within the tumor, called cancer stem cells. Therefore, this subpopulation of cells needs to be targeted with different approaches by identification of unique stem-cell specific target antigens. One of the well known tumor antigens is the epithelial cell mucin MUC4, which is aberrantly expressed in ovarian cancer as compared to the normal ovary and plays a pivotal role in the aggressiveness and metastasis of ovarian cancer cells. In the present study, we aimed to analyze the cancer stem cell population in MUC4 overexpressed ovarian cancer cells. Methods: MUC4 was ectopically overexpressed in SKOV3 ovarian cancer cells. Western blot analysis was performed for MUC4, HER2, CD133, ALDH1 and Shh expression in MUC4 overexpressed cells. Confocal analysis of MUC4, HER2 and CD133 was also done in the MUC4 overexpressed cells. CD133 and Hoechst33342 dye staining was used to analyze the cancer stem cell population via FACS method in SKOV3-MUC4 cells. Results: MUC4 overexpressed SKOV3 cells showed an increased expression of HER2 compared to control cells. MUC4 overexpression leads to increased (0.1%) side population (SP) and CD133-positive cancer stem cells compared to the control cells. Interestingly, the tumor sphere type circular colony formation was observed only in the MUC4 overexpressed ovarian cancer cells. Furthermore, the cancer stem cell marker CD133 was expressed along with MUC4 in the isolated circular colonies as analyzed by both confocal and western blot analysis. HER2 and cancer stem cell specific marker ALDH1 along with Shh, a self-renewal marker, showed increased expression in the isolated circular colonies compared to MUC4-transfected cells. Conclusion: These studies demonstrate that MUC4 overexpression leads to an enriched ovarian cancer stem cell population either directly or indirectly through HER2. In future, this study would be helpful for MUC4-directed therapy for the ovarian cancer stem cell population.
Compiling KB-Sized Machine Learning Models to Constrained Hardware

Recent breakthroughs in machine learning (ML) have produced models that can directly run on constrained IoT devices. This approach allows systems to avoid expensive communication between the IoT devices and the cloud, thereby enabling energy-efficient real-time analytics. However, ML models are expressed typically in floating-point, and IoT hardware typically does not support floating-point. Therefore, running these models on IoT devices requires simulating IEEE-754 floating-point using software, which is very inefficient. This paper presents SeeDot, a domain-specific language to express ML inference algorithms and an associated compiler which compiles SeeDot programs to fixed-point code that can efficiently run on constrained IoT devices. We propose 1) a novel compilation strategy that reduces the search space for some key parameters used in fixed-point code, and 2) new efficient implementations of expensive operations. For microcontrollers, our evaluation shows that SeeDotgenerated programs have comparable accuracy, are 2.4×– 11.9× faster than floating-point implementations, and up to two orders of magnitude faster than the code generated by a commercial float-to-fixed converter. SeeDot-based FPGA implementations are 18.7×–211.3× faster than microcontrollerbased implementations and 5.2×–9.8× faster than FPGA implementations generated by commercial high-level synthesis tools.
Determinants of Business Cycles Synchronization in the European Union and the Euro Area

Further economic and monetary integration in Europe is currently on hold due to the crisis and even questions about the possible exile of Greece. Especially in those conditions, it is important, to see whether integrated Europe can handle future problems and if economic and monetary integration can be helpful or rather more problematic. The main aim of this paper is to check to what degree business cycles are synchronized in the Eurozone and the European Union and what the main determinants of business cycles synchronization are. To achieve this, the following steps have been taken. Firstly, we turn to optimum currency area theory, to see what conditions need to be met, if the European Union and the euro area can use common monetary policy to deal with some economic shocks. Then, all necessary methodological explanations are presented. Later on, the preliminary data analysis is employed to see how business cycles and their determinants were acting during the last 20 years. Finally, panel data analysis is used to check how those determinants actually influence business cycles synchronization. The main finding of the article is that even though business cycles synchronization has been progressing in the European Union and the euro area so does the specialization – divergence in production structure. This may result in less synchronized business cycles in the future.
INFRARED H AND CO STUDIES OF THE GALACTIC CORE: GCIRS 3 AND GCIRS 1W

We have obtained improved spectra of key fundamental band lines of H, R(1, 1)l, R(3, 3)l, and R(2, 2)l, and ro-vibrational transitions of CO on sightlines toward the luminous infrared sources GCIRS 3 and GCIRS 1W, each located in the Central Cluster of the Galactic center within several arcseconds of Sgr A*. The spectra reveal absorption occurring in three kinds of gaseous environments: (1) cold dense and diffuse gas associated with foreground spiral/lateral arms; (2) warm and diffuse gas absorbing over a wide and mostly negative velocity range, which appears to fill a significant fraction of the Galaxy's Central Molecular Zone (CMZ); and (3) warm, dense and compact clouds with velocities near +50 km s−1 probably within 1–2 pc of the center. The absorptions by the first two cloud types are nearly identical for all the sources in the Central Cluster, and are similar to those previously observed on sightlines from Sgr A* to 30 pc east of it. Cloud type (3), which has only been observed toward the Central Cluster, shows distinct differences between the sightlines to GCIRS 3 and GCIRS 1W, which are separated on the sky by only 0.33 pc in projection. We identify this material as part of an inward extension of the circumnuclear disk previously known from HCN mapping. Lower limits on the products of the hydrogen ionization rate ζ and the path length L are 2.3 × 105 cm s−1 and 1.5 × 103 cm s−1 for the warm and diffuse CMZ gas and for the warm and dense clouds in the core, respectively. The limits indicate that the ionization rates in these regions are well above 10−15 s−1.
Using of Potential Functions Method for Recognition of Two Channels in Additive Noise

This article represents results of research of potential functions method in case of discrete signal with additive noise. Noise in transmission channel has Gaussian distribution, i.e. it is a white noise. Besides, noises in the channels have a static interrelation. The main aim of the paper is researching of applicability of the method of potential functions for recognition of the binary signal from it mix with additive noise. Number of researches have been conducted to assess the possibility of using the described method. The results were presented in a series of graphics. Tests were made for different numbers of parameters of the model, which had described in this paper. There was done comparative analysis of working of potential functions and k-nearest neighbors algorithm, which had considered in previous author’s works. The results of this research can be used as the base for further research and can be applicable in organization of transport channels.
A new model reference adaptive control for linear time-varying systems

Recent results on the adaptive control of linear time-varying systems have considered mostly the case in which the range or rate of parameter variations is small. In this paper, a new state feed-back model reference adaptive control is developed for systems with bounded arbitrary parameter variations. The important feature of the proposed adaptive control is an uncertainty estimation algorithm, which guarantees almost zero tracking error. Note that the conventional parameter estimation algorithm in the adaptive control guarantees only bounded tracking error. Copyright © 2000 John Wiley & Sons, Ltd.
Fishing for MSY: using “pretty good yield” ranges without impairing recruitment

‐ 28 Pretty Good Yield (PGY) is a sustainable fish yield corresponding to obtaining no less than a specified large 29 percentage of the Maximum Sustainable Yield (MSY). We investigated 19 European fish stocks to test the 30 hypothesis that 95% PGY yield range is inherently precautionary with respect to impairing recruitment. An F MSY 31 range was calculated for each stock as the range of fishing mortalities (F) that lead to an average catch of at 32 least 95% of MSY in the long term simulations. Further, a precautionary reference point for each stock (F P.05 ) 33 was defined as the F resulting in a 5% probability of the spawning stock biomass falling below an agreed 34 biomass limit below which recruitment is impaired (B lim ) in long ‐ term simulations. For the majority of the stocks 35 analysed, the upper bound of the F MSY range exceeded the estimated F P.05 . However, larger fish species had 36 higher precautionary limits to fishing mortality, and species with larger asymptotic length were less likely to have F MSY ranges impairing recruitment. Our study shows that fishing at F MSY generally is precautionary with 38 respect to impairing recruitment for highly exploited teleost species in Northern European waters whereas the 39 upper part of the range providing 95% of MSY is not necessarily precautionary for small and medium sized 40 teleosts. 41 42 MSY of the median landings when against values of F, with F MSY being the F value which corresponds to that peak. Estimated F ranges based on a fixed
The Impact of Organizational Structure and Business Strategy on Performance and Risk-Taking Behavior in Insurance Industry

This paper examines the impact of organizational structure and business strategy on company efficiency, profitability, and risk-taking behavior in the Taiwanese life insurance industry. The insurance industry in Taiwan provides an interesting environment for studying this issue because different organizational forms coexist in the insurance industry. We examine four different types of companies by organizational structure and two different business strategies. We use two frontier methodologies (stochastic frontier approach and data envelopment analysis approach) to measure the efficiency performance of insurance firms. The results show that organizational structures and business strategies have significant impact on efficiency, profitability, and risk-taking behavior. In addition, we also find size, lines of business, leverage ratio, and market share have significant impact on efficiency, profitability, and risk-taking behavior. Our overall evidence suggests that a more competitive environment should be encouraged in the Taiwanese insurance industry to improve the insurer efficiency.
Usability and Quality Parameters for E-Learning Environments and Systems

Authors address: Mirjana Ivanovic, Faculty of Sciences, Trg Dositeja Obradovica 4, 21000 Novi Sad, Serbia; e-mail: mira@dmi.uns. ac.rs; Aleksandra Klasnja Milicevic, Faculty of Sciences, Trg Dositeja Obradovica 4, 21000 Novi Sad, Serbia; email: akm@dmi.uns. ac.rs; Maria Ganzha, ul. Newelska 6, 01-447Warsaw, Poland; e-mail: maria.ganzha@ibspan.waw. pl; Amelia Badica, Faculty of economics and business administration 13, A.I. Cuza Street, Craiova, 200585, Romania; email:ameliabd@yahoo.com; Marcin Paprzycki, ul. Newelska 6, 01-447 Warsaw, Poland; e-mail: paprzyck@ibspan.waw. pl; Costin Badica, Department of computers and information technology, Blvd. Decebal nr. 107, RO-200440, Craiova, Romania; email: cbadica@software.ucv. ro;
Simultaneous Production of Biopolymer and Biosurfactant by Genetically Modified Pseudomonas Aeruginosa UMTKB-5

The simultaneous production of two biotechnologically important biomaterials, poly(3hydroxybutyrate) [P(3HB)], a well-known b iopolymer and rhamnolipid (RL), a type of biosurfactant in a single culture medium have been evaluated. Both ext racellular RL and the intracellular P(3HB) were produced from renewable resources by a genetically modified marine strain Pseudomonas aeruginosa UMTKB-5. The wild-type which was only ab le to p roduce RL was transformed by inserting plasmid pBBRPC1020 harboring polyhydroxyalkanoate (PHA) synthase gene of Cupriavidus sp. USMAA1020, a wellknown P(3HB) producer in order to produce RL as well as P(3HB). Various renewable carbon sources were used in this study such as simple sugars, oleo-chemical industry and sugar cane refinery by-products at a fix concentration of 20 g/L. The RL production by wild-type strain ranged from 54 to 272 mg/L, while the transformant was able to produce 40 to 56 mg/L. Production of P(3HB), the most common type of PHA, by the P. aeruginosa UMTKB-5 transformant was determined using gas chromatography and the strain was found to produce P(3HB) in the range of 9 to 24 (wt%). No P(3HB) were p roduced by wild-type from all the substrates. The highest P(3HB) content was detected using glycerol as carbon source in the genetically modified P. aeruginosa UMTKB-5. Conversely, a lower concentration of RL was produced by the transformant compared with wild-type strain. Th is may be due to the channeling of intermediate substrates for P(3HB) production as well as RL. This study reports the potential production of two biotechnologically important materials using bacterial fermentation in a single cultivation medium and carbon source.
Revisiting alkaline aerobic lignin oxidation

Lignin conversion to renewable chemicals is a promising means to improve the economic viability of lignocellulosic biorefineries. Alkaline aerobic oxidation of lignin has long been employed for production of aromatic compounds such as vanillin and syringaldehyde, but this approach primarily focuses on condensed substrates such as Kraft lignin and lignosulfonates. Conversely, emerging lignocellulosic biorefinery schemes enable the production of more native-like, reactive lignin. Here, we revisit alkaline aerobic oxidation of highly reactive lignin substrates to understand the impact of reaction conditions and catalyst choice on product yield and distribution. The oxidation of native poplar lignin was studied as a function of temperature, NaOH loading, reaction time, and oxygen partial pressure. Besides vanillin and syringaldehyde, other oxidation products include acetosyringone and vanillic, syringic, and p-hydroxybenzoic acids. Reactions with vanillin and syringaldehyde indicated that these compounds are further oxidized to non-aromatic carboxylic acids during alkaline aerobic oxidation, with syringaldehyde being substantially more reactive than vanillin. The production of phenolic compounds from lignin is favored by high NaOH loadings and temperatures, but short reaction times, as the products degrade rapidly, which is further exacerbated by the presence of oxygen. Under optimal conditions, a phenolic monomer yield of 30 wt% was obtained from poplar lignin. Testing a range of catalysts showed that Cu-containing catalysts, such as CuSO4 and LaMn0.8Cu0. 2O3, accelerate product formation; specifically, the catalyst does not increase the maximum yield, but expands the operating window in which high product yields are obtainable. We also demonstrate that other native and isolated lignin substrates that are significantly chemically modified are effectively converted to phenolic compounds. Finally, alkaline aerobic oxidation of native lignins was compared to nitrobenzene oxidation and reductive catalytic fractionation, as these methods constitute suitable benchmarks for lignin depolymerization. While nitrobenzene oxidation achieved a somewhat higher yield, similar monomer yields were obtained through RCF and alkaline aerobic oxidation, especially for lignins with a high guaiacyl- and/or p-hydroxyphenyl-content, as syringyl units are more unstable during oxidation. Overall, this study highlights the potential for aerobic lignin oxidation revisited on native-like lignin substrates.