Miracle-dz/UniFAR-FTUs huggingface dataset:
Proteus, Matrine, and Pyridalyl Toxicity and Their Sublethal Effects on Orius laevigatus (Hemiptera: Anthocoridae)

Abstract Proteus, matrine, and pyridalyl were tested in the laboratory for their effects upon Orius laevigatus (Fieber), which is a polyphagous predator used for IPM programs of Frankliniella occidentalis (Pergande). Against female adults, the most toxic insecticide was Proteus (LC50 = 44.3 µl L–1), followed by pyridalyl (LC50 = 83.8 µl L–1) and matrine (LC50 = 102.7 µl L–1). The mortality of female adults was checked 24, 48, 72, and 96 h after exposure to 14-d residues of the treatments on strawberry leaves. The residual of Proteus was less toxic; the remaining products caused the lowest mortality at different times after exposure. Sublethal treatments (LC25) significantly prolonged the developmental duration of total immature stages from 17.6 d in control to 21.6 and 20.0 d in Proteus and pyridalyl treatments, respectively. Also, the fecundity of O. laevigatus treated with Proteus, pyridalyl, and matrine decreased to 58.8%, 75.6%, and 96.7%, respectively, in comparison to the control. Compared with the control population (0.118 d–1), the intrinsic rate of increase (r) of F1 generation decreased by 0.053, 0.095, and 0.110 d–1 in Proteus, pyridalyl, and matrine treatments, respectively. The consumption rate of control bugs reached 14.0 thrips during 24 h. The adults fed on Proteus treatment had the lowest consumption rate in this period (9.4 preys). Overall, matrine proved to be harmless with reproductive capacity and r similar to what was recorded in control bugs. We concluded that matrine can be used as an alternative for the synthetic insecticide to integrate with O. laevigatus.
In vitro and in silico interactions of antiulcer, glucocorticoids and urological drugs on human carbonic anhydrase I and II isozymes

Carbonic anhydrases (CAs, Enzyme Commission 4.2.1.1) convert carbon dioxide to bicarbonate in metabolism and use Zn2+ ions as a cofactor for their catalytic activity. The activators or inhibitors of CA‐I and CA‐II, which are the most abundant CA isozymes in erythrocytes, have pharmacological applications in medicine. So, investigation of drug‐protein interaction of these isozymes is significant. On this basis, the objective of this study was to clarify the primer effects of widely used drugs on the activity of human CA‐I and CA‐II enzymes and elucidate the inhibition mechanism through molecular docking studies. For this aim isozymes were purified from human erythrocytes by affinity chromatography technique. Then inhibition profiles of antiulcer, glucocorticoids, and urological drugs were investigated. As a result, while budesonide had the highest inhibitory potency on hydratase activity of hCA‐I with the IC50 of 0.08 mM, levofloxacin showed the highest inhibition effect on hCA‐II with the IC50 of 0.886 mM. The most effective inhibitor on the esterase activity of isozymes was found as fluticasone propionate with the Ki values of 0.0365 ± 0.016 mM and 0.054 ± 0.018 mM respectively. However, by molecular docking study, it was estimated that budesonide showed maximum inhibition potency for both isozymes with the free binding energy of −7.58 and −6.97 kcal/mol, respectively. Consequently, it was observed that some of the drugs studied did not show any inhibitory effect. Drug‐enzyme interactions were also estimated by molecular docking. This study could contribute to the discovery of new drug candidates and as well as target proteins.
Dissection of the genetic architecture of peduncle vascular bundle‐related traits in maize by a genome‐wide association study

Summary The peduncle vascular system of maize is critical for the transport of photosynthetic products, nutrients, and water from the roots and leaves to the ear. Accordingly, it positively affects the grain yield. However, the genetic basis of peduncle vascular bundle (PVB)‐related traits in maize remains unknown. Thus, 15 PVB‐related traits of 386 maize inbred lines were investigated at three locations (Yongcheng, 17YC; Kaifeng, 20KF; and Yuanyang, 20YY). The repeatability for the 15 traits ranged from 35.53% to 92.13%. A genome‐wide association study was performed and 69 non‐redundant quantitative trait loci (QTL) were detected, including 9, 41, and 27 QTL identified at 17YC, 20KF, and 20YY, respectively. These QTL jointly explained 4.72% (SLL) to 37.30% (NSVB) of the phenotypic variation. Eight QTL were associated with the same trait at two locations. Furthermore, four pleiotropic QTL were identified. Moreover, one QTL (qPVB44), associated with NSVB_20KF, was co‐localized with a previously reported locus related to kernel width, implying qPVB44 may affect the kernel width by modulating the number of small vascular bundles. Examinations of the 69 QTL identified 348 candidate genes that were classified in five groups. Additionally, 26 known VB‐related homologous genes (e.g. VLN2, KNOX1, and UGT72B3) were detected in 20 of the 69 QTL. A comparison of the NSVB between a Zmvln2 EMS mutant and its wild type elucidated the function of the candidate gene ZmVLN2. These results are important for clarifying the genetic basis of PVB‐related traits and may be useful for breeding new high‐yielding maize cultivars.
Refine-Net: Normal Refinement Neural Network for Noisy Point Clouds

Point normal, as an intrinsic geometric property of 3D objects, not only serves conventional geometric tasks such as surface consolidation and reconstruction, but also facilitates cutting-edge learning-based techniques for shape analysis and generation. In this paper, we propose a normal refinement network, called Refine-Net, to predict accurate normals for noisy point clouds. Traditional normal estimation wisdom heavily depends on priors such as surface shapes or noise distributions, while learning-based solutions settle for single types of hand-crafted features. Differently, our network is designed to refine the initial normal of each point by extracting additional information from multiple feature representations. To this end, several feature modules are developed and incorporated into Refine-Net by a novel connection module. Besides the overall network architecture of Refine-Net, we propose a new multi-scale fitting patch selection scheme for the initial normal estimation, by absorbing geometry domain knowledge. Also, Refine-Net is a generic normal estimation framework: 1) point normals obtained from other methods can be further refined, and 2) any feature module related to the surface geometric structures can be potentially integrated into the framework. Qualitative and quantitative evaluations demonstrate the clear superiority of Refine-Net over the state-of-the-arts on both synthetic and real-scanned datasets.
Efficacy of pulsed electromagnetic field on pain and physical function in patients with low back pain: A systematic review and meta-analysis

Objective To assess the effectiveness of pulsed electromagnetic field (PEMF) on pain and physical function in patients with low back pain. Data sources A search of PubMed, Embase, Cochrane Library, and Web of Science was conducted up to December 2021. Methods We included randomized controlled trials that investigated the effectiveness of PEMF in patients with low back pain. The primary outcome was pain intensity and the secondary outcome was physical function, both were evaluated by assessment scales. Standardized mean difference (SMD) and 95% confidence interval (CI) were calculated for the summary statistics analysis. The registration number of this systematic review in PROSPERO is CRD42020213829. Results Fourteen trials involving 618 participants were included. The PEMF treatment showed more significant pain alleviation than placebo or other therapy alone in patients with low back pain (SMD = −1.01, 95% CI −1.42 to −0.6, P < 0.001, I2 = 31%; SMD = −0.36, 95% CI −0.62 to −0.11, P = 0.005, I2 = 37%, respectively.) In addition, a significant difference in pain alleviation was observed in patients with chronic low back pain (SMD = −0.6, 95%CI − 0.94 to −0.25, p < 0.001, I2 = 67%), whereas no significant difference was observed in patients with acute low back pain (SMD = −0.46, 95%CI − 0.99 to 0.07, p = 0.09, I2 = 0%). PEMF did not improve physical function compared with the control treatment (SMD = −0.45, 95% CI − 0.98 to 0.07, p = 0.09, I2 = 86%). Conclusion PEMF is beneficial for alleviating pain in patients with chronic low back pain despite having no advantage in improving physical function.
Clinical and Biologic Characteristics and Outcomes in Young and Middle-Aged Patients With Laryngeal Cancer: A Retrospective Cohort Analysis

Objective To describe the clinical and biologic characteristics and outcomes of young and middle-aged (YMA; <65 years) patients according to the presence or absence of traditional risk factors for laryngeal cancer. Study Design Retrospective cohort analysis. Setting Single-institution academic medical center. Methods Patients without a history of clinically significant tobacco use or heavy alcohol use were defined as “nontraditional”: ≤5 pack-years, ≤5 years smoked, ≤14 alcoholic drinks per week, and ≥15-year interval from last tobacco abuse use to diagnosis. Remaining patients were categorized as “traditional. ” Select tumor samples were evaluated for bacterial and viral DNA by multiplex polymerase chain reaction. Results Seventy-eight YMA patients with primary laryngeal squamous cell carcinoma were identified, 23% (n = 18) of whom were nontraditional. Nontraditional patients were younger than traditional patients (median age, 51 vs 59 years; P < .001). Twenty-eight tumors were prospectively tested for human papillomavirus (HPV), and nontraditional patients were more likely to exhibit high-risk HPV (57% vs 5%, P < .01). Among 17 select tumors (nontraditional, n = 8; traditional, n = 9), 35% exhibited HPV16 (nontraditional, 63%; traditional, 11%; P = .05). Other viruses were identified but did not differ according to risk status: herpesviruses (40%) and Merkel cell polyomavirus (7%). Chlamydia, β-HPV, and γ-HPV DNA was not detected in any samples. Median length of follow-up was 42 months. On adjusted analyses, nontraditional patients exhibited nonsignificantly improved overall survival (hazard ratio, 0.24 [95% CI, 0.03-1.82]; P = .17) and disease-free survival (hazard ratio, 0.34 [95% CI, 0.10-1.23]; P = .08) as compared with traditional patients. Conclusion Almost one-quarter of YMA patients lacked characteristic risk factors for laryngeal squamous cell carcinoma, and their tumors exhibited a higher prevalence of high-risk HPV. The significance of HPV16 and other tumor viruses with outcomes in nontraditional patients should be evaluated further.
Autologous Fat Grafting as Treatment of Postmastectomy Pain Syndrome: A Randomized Controlled Trial

Background: Postmastectomy pain syndrome is a common and disabling side effect of breast cancer treatment. Medical treatment seems to be insufficient for a considerable proportion of patients. Fat grafting has shown promise in relieving pain from postmastectomy pain syndrome, but no randomized clinical trial comparing fat grafting to a sham operation has been performed to date. The authors’ objective was to compare the effect of fat grafting compared to a sham operation for treating postmastectomy pain syndrome. Methods: The authors conducted a single-center, double-blind, randomized clinical trial with two arms between October of 2017 and September of 2020. The authors assessed four patients suffering from postmastectomy pain syndrome for inclusion. The intervention group received scar-releasing rigottomy and fat grafting to the area of pain. The control group received scar-releasing rigottomy and a placebo of saline solution. The primary outcome was the degree of pain measured using the Numerical Rating Scale. The secondary outcomes were the degree and quality of neuropathic pain (Neuropathic Pain Symptom Inventory) and quality of life (36-Item Short-Form Health Survey). Follow-up was 6 months. Results: Thirty-five participants completed follow-up: 18 participants in the intervention group and 17 in the control group. The authors detected no statistically significant changes in average and maximum pain or neuropathic pain. Regarding quality of life, the control group reported a statistically significant improvement in emotional problem parameters, whereas the intervention group reported a deterioration. The authors observed no serious adverse effects. Conclusion: The authors did not find evidence to support that fat grafting is superior to a placebo when treating postmastectomy pain syndrome. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, I.
Commensal oral microbiota induces osteoimmunomodulatory effects separate from systemic microbiome in mice

Commensal microbes critically regulate skeletal homeostasis, yet the impact of specific microbiota communities on osteoimmune response mechanisms is unknown. To discern osteoimmunomodulatory effects imparted by the commensal oral microbiota that are distinct from the systemic microbiota, osteoimmunology studies were performed in both alveolar bone and nonoral skeletal sites of specific pathogen–free (SPF) versus germ-free (GF) mice and SPF mice subjected to saline versus chlorhexidine oral rinses. SPF versus GF mice had reduced cortical/trabecular bone and an enhanced pro-osteoclastic phenotype in alveolar bone. TLR signaling and Th17 cells that have known pro-osteoclastic actions were increased in alveolar BM, but not long BM, of SPF versus GF mice. MHC II antigen presentation genes and activated DCs and CD4+ T cells were elevated in alveolar BM, but not long BM, of SPF versus GF mice. These findings were substantiated by in vitro allostimulation studies demonstrating increased activated DCs derived from alveolar BM, but not long BM, of SPF versus GF mice. Chlorhexidine antiseptic rinse depleted the oral, but not gut, bacteriome in SPF mice. Findings from saline- versus chlorhexidine-treated SPF mice corroborated outcomes from SPF versus GF mice, which reveals that the commensal oral microbiota imparts osteoimmunomodulatory effects separate from the systemic microbiome.
Momentum, Rather Than Velocity, Is a More Effective Measure of Improvements in Division IA Football Player Performance

Abstract Mann, JB, Mayhew, JL, Dos Santos, ML, Dawes, JJ, and Signorile, JF. Momentum, rather than velocity, is a more effective measure of improvements in Division IA football player performance. J Strength Cond Res 36(2): 551–557, 2022—Speed, or the time to complete straight runs or agility drills, is commonly used to assess performance in collegiate American football players. However, it is common for players' speeds to plateau by the second year of eligibility, whereas their body masses continue to increase. The purpose of this study was to track change in speed, body mass, and momentum (body mass · velocity), across Division 1 football players' 4-year careers (n = 512). Complete data were derived for the 40-yd sprint (n = 82), the proagility shuttle (n = 73), and the L drill (n = 73) from the same NCAA Division 1 team over a 15-year period. Significant changes were seen for velocity between year 1 and the next 3 playing years (p < 0.05), with no differences between years 2 and 4, whereas body mass increased significantly across all playing years (p < 0.05). Further momentum increased across all years for all tests (p < 0.0001). These results indicate the importance of including changes in body mass when evaluating performances during sprints and change of direction drills. Our results also suggest that using sprint or agility drill times to evaluate playing potential across football players' collegiate careers may be ineffective and can provide players with a false and disheartening picture of their improvements across their careers. Momentum, which incorporates training-induced increases in both speed and body mass, would be a more relevant and supportive measure of players' improvements. In addition, the simple computation of this variable, using existing speed and body mass data, may be an important addition to the National Football League combine as a measure of playing potential in the professional game.
Inter-brain neural mechanism underlying turn-based interaction under acute stress in women: a hyperscanning study using functional near-infrared spectroscopy

Abstract With the ever-changing social environment, stress has exerted a substantial influence on social interaction. The present study examined the underlying cognitive and neural mechanism on how acute stress affected the real-time cooperative and competitive interaction with four hypothesized path models. We used the hyperscanning technique based on functional near-infrared spectroscopy (fNIRS) device to examine brain-to-brain coherence within the dyads engaging Pattern Game under acute stress manipulated through Trier Social Stress Test for Groups. Behavioral results showed stressed dyads exhibited better cooperative performance and higher self-other overlap level during the cooperative session than dyads in the control group. The fNIRS results identified higher interpersonal brain synchronization in the right temporal-parietal junction (r-TPJ) stronger Granger causality from partner-to-builder during the cooperative session in the stress group when compared with the control group. Our results corroborated better performance in the cooperative context and further identified that brain-to-brain coherence in r-TPJ and self-other overlap serially mediated the effect of acute stress on cooperative performance.
Computational Neuroscience Approach to Psychiatry: A Review on Theory-driven Approaches

Translating progress in neuroscience into clinical benefits for patients with psychiatric disorders is challenging because it involves the brain as the most complex organ and its interaction with a complex environment and condition. Dealing with such complexity requires powerful techniques. Computational neuroscience approach to psychiatry integrates multiple levels and types of simulation, analysis and computation according to the different types of computational models to enhance comprehending, prediction and treatment of psychiatric disorder. This approach comprises two approaches: theory-driven and data-driven. In this review, we focus on recent advances in theory-driven approaches that mathematically and mechanistically examine the relationships between disorder-related changes and behavior at different level of brain organization. We discuss recent progresses in computational neuroscience models that relate to psychiatry and show how principles of neural computational modeling can be employed to explain psychopathology.
A 10-year retrospective analysis of the clinical profile and outcomes of infective endocarditis at a tertiary hospital in KwaZulu-Natal, South Africa.

OBJECTIVE To examine the clinical profile and treatment outcomes of infective endocarditis (IE) at a tertiary hospital in KwaZulu-Natal. METHODS A 10-year retrospective analysis was conducted on cases of definite IE (modified Duke criteria). RESULTS Ninety-seven subjects (HIV infected, n = 12) satisfied the study criteria (mean age 29.7 ± 15.6 years, M:F 1.4:1). Underlying rheumatic heart disease was present in 84.5% and severe dyspnoea in 67.0% of cases. Staphylococcus aureus was the commonest pathogen isolated (18.6%). Heart failure was present in 61.9% and vegetations were identified in 85 (87.6%) subjects, resulting in 41 (42.3%) embolic events. The clinical profile and outcomes were similar in the HIV-positive and -negative patients. Surgery was performed in 73 subjects (surgical mortality rate 9.5%, total mortality rate 26.4%). Multivariate analysis identified acute-onset IE [odds ratio (OR) 251.46, 95% confidence interval (CI) 1.18-5343.63, p = 0.043], vegetation size > 15 mm (OR 222.60, 95% CI 1.04-4730.34, p = 0.043) and medical management only (OR 20.89, 95% CI 2.12-200.06, p = 0.037) as predictors for increased in-hospital mortality. CONCLUSION IE affects young people with underlying rheumatic heart disease and is associated with high morbi-mortality attributable to advanced disease at presentation and to haemodynamic failure resulting from valve destruction due to acute onset of aggressive infection.
Cross‐hierarchical plasticity of corticofugal projections to dLGN after neonatal monocular enucleation

Perception is the result of interactions between the sensory periphery, thalamus, and cerebral cortex. Inputs from the retina project to the first‐order dorsal lateral geniculate nucleus (dLGN), which projects to the primary visual cortex (V1). In return, the cortex innervates the thalamus. While layer 6 projections innervate all thalamic nuclei, cortical layer 5 neurons selectively project to the higher order lateral posterior nucleus (LP) and not to dLGN. It has been demonstrated that a subpopulation of layer 5 (Rbp4‐Cre+) projections rewires to dLGN after monocular or binocular enucleation in young postnatal mice. However, the exact cortical regional origin of these projections was not fully determined, and it remained unclear whether these changes persisted into adulthood. In this study, we report gene expression changes observed in the dLGN after monocular enucleation at birth using microarray, qPCR at P6, and in situ hybridization at P8. We report that genes that are normally enriched in dLGN, but not LP during development are preferentially downregulated in dLGN following monocular enucleation. Comparisons with developmental gene expression patters in dLGN suggest more immature and delayed gene expression in enucleated dLGN. Combined tracing and immuno‐histochemical analysis revealed that the induced layer 5 fibers that innervate enucleated dLGN originate from putative primary visual cortex and they retain increased VGluT1+ synapse formation into adulthood. Our results indicate a new form of plasticity when layer 5 driver input takes over the innervation of an originally first‐order thalamic nucleus after early sensory deficit.
A Grading Solution for Building Digital Station

IEC 61850 standard solves the interoperation problem between IEDs of multi-vendors. The design of primary and secondary for digital station based on IEC 61850 standard will be simplified. After listing and analyzing much problem when implementing a digital station, a solution suitable for current stage is proposed. It is focused on the network configuration and process layer. Easy practice and promotion are the advantage of this solution.
Auto-identification of two Sitophilus sibling species on stored wheat using Deep Convolutional Neural Network.

BACKGROUND Sitophilus oryzae and Sitophilus zeamais are the two main insect pests that infest stored grain worldwide. Accurate and rapid identification of the two pests is challenging because of their similar appearances. The S. zeamais adults are darker and shinier than S. oryzae in visible light. Convolutional Neural Network (CNN) can be applied for the effective differentiation due to its high effectiveness in object recognition. RESULTS We propose a Multilayer Convolutional Structure (MCS) feature extractor to extract insect characteristics within each layer of the CNN architecture. A Region Proposal Network is adopted to determine the location of a potential pest in the wheat background. The precision of classification and the robustness of bounding box regression are increased by including deeper layer variables into the classification and bounding box regression subnets, as well as combining loss functions softmax and smooth L1. The proposed MCSNet achieves the mean Average Precision of 87.89±2.36% from the laboratory test, with an average detection speed of 0.182±0.005s per test. The model was further assessed with the field trials, and the obtained accuracy was 90.35±3.12%. For all test conditions, the Average Precision for S. oryzae was higher than that for S. zeamais. CONCLUSION The proposed MCSNet model has demonstrated that a fast and accurate method for detecting sibling species from visible light images in both lab and field trials. This will ultimately be applied for pest management together with an upgraded industrial camera system, which has been installed in over 100,000 grain depots of China.