Miracle-dz/UniFAR-FTUs huggingface dataset:
Cross-linked natural gum microspheres: a feasible attitude for boosting the delivery of dicyclomine hydrochloride

Microspheres are fundamentally free-flowing powders consisting of a biodegradable polymer matrix where an active therapeutic agent dispersed uniformly within the matrix system and the loaded drug released in a controlled manner over a long period. As a modern drug-captured delivery tool, controlled drug delivery system released the entrapped drugs at the target site in a controlled manner. The focus of the present investigation is to design a microsphere formulation based on the drug-polymer ratio. Other parameters related to the formulation kept constant. Dicyclomine hydrochloride loaded guar gum-based microsphere was accomplished by ionotropic gelation method and characterized by different process parameters like particle size, entrapment efficiency etc. The compatibility study of drug with formulation components was confirmed by differential scanning calorimetry and fourier transform infrared study. The particle size increased with enhancing the amount of guar gum. In vitro release profile was done using USP dissolution apparatus II in different pH media which was found to be a pH-sensitive profile after 12 h. The release kinetics was fitted with zero-order kinetics and case II transport system according to the Korsmeyer-Peppas model. The present study introduces an approach for the fabrication of microspheres for prolonged release of Dicyclomine hydrochloride and it can be used effectively as a drug targeting delivery tool with increased therapeutic efficacy.
Understanding the internet AS topology and its applications

Autonomous Systems (AS) in the Internet use BGP to perform inter-domain routing. A set of import and export policies at an AS make up the routing table of an AS. Since AS relationships are not publicly available, several studies have proposed heuristic algorithms for inferring AS relationships using publicly available BGP data. Content Delivery Network (CDN) servers placed around the world cater to the needs of clients that access their content. Since, the majority of the Internet traffic today is content delivery traffic, it is important to study the efficiency of the routing paths from users to content servers which are not under the control of content providers. Netflix and Akamai are two major CDN providers. The user experience depends upon the performance of CDN servers. Hence, it is important for CDNs to choose the ideal server when a user requests content from its network. Due to lack of authentication of routes in BGP, prefixes are prone to being hijacked by ASes to which the prefixes do not belong. The mechanisms used to address this is to detect the hijack after it has happened and react to it. A more preventive mechanism is necessary to prevent it from happening in the first place. A recent work proposed a list of serial hijackers that would enable such a solution. Unfortunately, the ground truth of serial hijackers is very small. We try to understand the Internet AS Topology using BGP routing data received from neighbors of an AS. We present a machine learning approach to edge type inference in AS graphs. We use our method to train classifiers for three AS graphs derived from different data sources–a BGP graph, a trace-route graph, and an IRR graph. The classifier annotated the edges into p2c and p2p edge types. We merge the three individual graphs to obtain a combined graph and propose a method to compute edge types in the combined graph. We analyze the characteristics of the three individual graphs and the combined graph and show that combining the three individual graphs gives us a
Effects of supplement type and narasin inclusion on supplement intake by Bos indicus beef bulls grazing a warm-season forage

Abstract This study aimed to evaluate the effects of supplement type and narasin inclusion on the frequency and supplement intake of grazing Bos indicus beef bulls. Four hundred animals were ranked by initial BW (383 ± 35 kg) and allocated into one of four paddocks of Brachiaria brizantha cv. Marandú (100 animals/paddock). Paddocks were randomly assigned to receive either a mineral salt (MIN) or a protein-energetic supplement (PREN) containing or not narasin (N) for a 90-d period. An individual electronic data capture system with 11 feed bunks was used to individually measure supplement intake and meal frequency in each paddock. The evaluations and analysis of individual intake, frequency of visits to the feeder, and intake per visit (I/V) were performed every 15 d and classified as periods (PR1 through PR6). All data were analyzed as a 2 × 2 factorial design with the PROC MIXED procedure of SAS. A supplement type × N × PR interaction was observed (P < 0.0001) for daily supplement intake. No differences were observed between MIN, whereas PREN had a greater (P ≤ 0.03) supplement intake on PR1 and PR3, but a reduced supplement intake on PR6 compared with PREN + N (P = 0.02). Moreover, no supplement type × N interaction (P = 0.47) or N (P = 0.44) effects were observed for daily supplement intake in the present study. A supplement type × N × PR interaction was detected (P < 0.0001) for the frequency of visits in the feeders. Throughout the experimental period, animals from the MIN + N had a greater (P ≤ 0.02) frequency of visits compared with MIN cohorts. A supplement effect was detected for I/V (P = 0.02), whereas neither a narasin effect (P = 0.74) nor interactions (P ≥ 0.16) were observed. Animals offered PREN had a greater I/V when compared with MIN cohorts (145 vs. 846 g/d for MIN and PREN, respectively; SEM = 16.1). When these data are reported as percentage of days visiting the feeder within each PR, MIN and MIN + N animals visited the feeder for 25.8% and 35.9% of the days, respectively. Conversely, no differences were observed (P = 0.65) in the overall mean visits per PR between PREN and PREN + N (12.8 vs. 12.3 d for PREN and PREN + N, respectively; SEM = 0.195). As percentage of days visiting the feeder, PREN and PREN + N visited the feeder for 85.1% and 81.9% of the days, respectively. In summary, narasin inclusion did not reduce supplement intake, regardless of supplement type, but increased the frequency of visits to the feeder for the MIN treatment.
The Effect of Cobalt (II) Chloride in the Viability Percentage and the Induced Hypoxia Inducible Factor -1α of Human Adipose Mesenchymal Stem Cells (HAMSCs): An In Vitro Study

Introduction: The preconditioning of HAMSCs using Cobalt (II) Chloride (CoCl2) as a hypoxia mimicking agent (HMA) may provide the adaptive state of HAMSCs. Objective: To examine the effect of CoCl2 in the viability percentage and the induced Hypoxia Inducible Factor-1α (HIF-1α) expression of HAMSCs in vitro. Methods: HAMSCs were thawed, cultured, and then sub-cultured from the laboratory cell stock. The Immunocytochemistry (ICC) methods with Fluorescein isothiocyanate (FITC) antibody labelling kit was used to validate the HAMSCs employing its Cluster of Differentiation (CD) expression such as CD73(+), CD105(+) and CD45(-). HAMSCs were sub-cultured and then co-cultivated with or without CoCl2 in the different concentration (200mol, 150mol, 100mol, 75mol, 50mol, 25mol) for 24 hours. The cytotoxicity test was conducted by utilizing tetrazolium dye MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. The formazan crystal was then observed, and the cell viability percentage was calculated. In examining CoCl2 induced hypoxia in HAMSCs, the expression of HIF-1α applied ICC-FITC in vitro. Analysis of Variance (ANOVA) was performed to analyze the obtained data statistically (p0.05). CoCl2 successfully induces the hypoxia confirmed by HIF-1α positive expression of HAMSCs after 24 hours incubation in vitro. Conclusion: CoCl2 does not affect the viability percentage of HAMSCs and it can be used as a biocompatible HMA in HAMSCs in vitro.
Ducted Savonius Turbine Performance: A Multi-Application Approach

In the last decades, the public opinion has paid great attention to environmental pollution and global warming. Energy sector has a strong impact on environment. Thus, the use of renewable energies is becoming mandatory. The present paper deals with a study of ducted Savonius turbine performance as a function of geometric and operating parameters. Ducted turbines could be used as power take-off in multiple applications. In this paper, two main applications were studied. The first application is related to the possibility to install the turbine inside building with the purpose of architectonic integration of the system. The second one is related to wave energy harvesting. In both cases the same type of turbine was used to convert input energy (wind or wave energy) into electricity. Turbine performance were studied as a function of turbine overlap ratio, as well as air flux oscillating frequencies. On the basis of the obtained results, turbine performance increase in ducted configuration and a change in best overlap ratio was registered.
Analysis of Implementation of POAC Model and Management Information System for Academic Performance

---Education aims to build human resources through character education and skills training in Vocational High Schools (VHS). This study contains the results of analysis implementation for management functions (Planning, Organizing, Actuating and Controlling) and management information systems (MIS) to fulfill the achievement National Education Standards (NES). The Education Quality Report of the Central Java Province 2016, achievement of NES in Semarang’s VHS is 3 of 5 levels. To fulfillment of MIS quality academic performance have been implemented SIAP-PADAMU NEGERI Application since 2016, but still requires analysis to develop model of management function and MIS to be used for developing academic performance evaluation models. This research was questionnaire to 21 respondents in 7 Semarang’s VHS used the Mix Methods with Technology Acceptance Model (TAM) research approach. The results is 80.88% of Semarang’s VHS have used POAC management functions for school academic performance but function of information technology itself hasn’t implemented optimally.
Single fiber proteomics of respiratory chain defects in mitochondrial disorders

Mitochondrial DNA mutations progressively compromise the respiratory chain of skeletal muscle, resulting in a mosaic of metabolically healthy and defective fibers. The single fiber investigation of this important diagnostic feature has been beyond the capability of large-scale technologies so far. We used laser capture microdissection (LCM) to excise thin sections of individual muscle fibers from frozen biopsies of patients suffering from chronic progressive external ophthalmoplegia. We then applied a highly sensitive mass spectrometry (MS)-based proteomics workflow to analyze healthy and defective muscle fibers within the same biopsy. We quantified more than 4000 proteins in each patient, covering 75% of all respiratory chain subunits, and compared their expression in metabolically healthy and defective muscle fibers. Our findings show that mitochondrial disease causes extensive proteomic rearrangements, affecting the OPA1-dependent cristae remodeling pathway and mitochondrial translation. We provide fiber type-specific information showing that increased expression of fatty acid oxidation enzymes occurs in defective slow but not fast muscle fibers. Our findings shed light on compensatory mechanisms in muscle fibers that struggle with energy shortage and metabolic stress.
Two-Dimensional Localization: Low-Rank Matrix Completion With Random Sampling in Massive MIMO System

In this paper, random sampling is considered for direction-of-arrival (DOA) estimation with reduced hardware complexity in massive multiple-input–multiple-output (MIMO) systems. The resulting problem is that the accuracy of the existing DOA estimators will significantly degrade with the availability of only a small subset of data entries as the low date rate is employed to reduce the system power consumption. To address that, an efficient approach based on the variant of matrix factorization is devised to complete the underlying data matrix. As a result, the nominal azimuth and elevation DOAs with the corresponding angular spreads are estimated from the underlying data matrix. Numerical results demonstrate that even in the case of missing entries, the proposed method is superior to the existing approaches with full data.
Quantification of lactoferrin in milk from New Zealand dairy goats

Lactoferrin (Lf), an iron-binding protein, plays a key part in host defence with diverse protective roles in infection and inflammation, including allergy. It is present in most mucosal secretions, including colostrum and milk. To quantify the levels of Lf in milk from New Zealand dairy goats, a sandwich enzyme-linked immunosorbent assay (ELISA) was established. Purified Lf, extracted from goat colostrum, was used to raise antibodies in rabbits and for ELISA standards. The ELISA method involved coating goat Lf antibody onto microtitre plates then sequential addition of standard or test samples, biotinylated-goat Lf antibody and streptavidin-biotin conjugate, with a colorimetric endpoint employing 3,3',5,5'-tetramethylbenzidine. The intra and inter assay coefficient of variation was 4.1% and 7.8%, respectively. Average recovery of added Lf was 104.5%. Cross reactivity with bovine Lf was 40% and negligible for other milk proteins tested. In goat milk samples collected over the lactation season, the average Lf concentration was 31.8 ± 7.3 (standard error of the mean); 33.4 ± 5.2 and 821.8 ± 269.4 mg/L, in early, midand late season, respectively. An ELISA method has been developed that accurately and reproducibly measures Lf in goat milk samples. Lf levels in New Zealand goat milk are similar to those reported for the cow.
Vibration Mode Analysis for a Suspension Bridge by Using Low-Frequency Cantilever-Based FBG Accelerometer Array

In this article, we present a vibration measurement system based on low-frequency cantilever-based fiber Bragg grating accelerometers (CFAs) for a suspension bridge. Each accelerometer has an end-loaded cantilever beam, specifically tailored to achieve a uniform sensitivity for a frequency range of 0–4 Hz, a suitable detection range for the vibration analysis. In the field test, seven CFAs were installed at specific positions along the deck of a 110-m-long suspension bridge for synchronous multipoint vibration measurements. The reflection spectra of the CFA array were recorded and processed using the pseudo-high-resolution scheme to improve the signal quality and measurement accuracy. Three natural vibration frequencies: 1.15, 1.54, and 3.17 Hz have been identified from the measurement. Following that, the acquired time-domain signals were processed by a digital bandpass filter to retrieve the waveform at each natural frequency to determine the corresponding mode shapes. The results are in agreement with the phase difference between the frequency domain signal for each natural frequency. This investigation has shown the feasibility of the proposed measurement system for determining the mode shapes and dynamic frequency analysis of a suspension bridge. It is a potential method for structural health monitoring for other similar civil structures.
Association between Oral Anticoagulants and the Risk of Cardiogenic Thromboembolism in Patients with Atrial Fibrillation Undergoing Cancer Chemotherapy

BACKGROUND Oral anticoagulant treatments (OATs) are used in patients with atrial fibrillation (AF) to prevent complications. However, continuous treatment with OATs during chemotherapy in AF patients with cancer is controversial due to increased bleeding concerns. Thus, we aimed to evaluate whether OAT treatment decreased the risk of cardiogenic thromboembolism in those patients. We conducted a retrospective cohort study using a Japanese administrative database includ‐ ing patients with AF aged ≥18 years who underwent chemotherapy between 2008 and 2017 and had used OATs before starting chemotherapy. We divided patients into two groups; con‐ tinuous users and discontinuous users of OATs within 90 days after starting chemotherapy. We calculated the incidence of cardiogenic thromboembolism. Also, we estimated the hazard ratio (HR) and 95% confidence intervals (CIs) of it using Cox proportional hazards models, including matched propensity scores (PSs), to adjust for comorbidities. ment (mean age, 76.2 years; 75.9% male) and 1,596 (24.9%) patients discontinued OAT treatment (mean age, 76.2 years; 76.6% male). PS matching created a cohort of 1,596 matched pairs. The incidence of cardiogenic thromboembolism among the continuation group and the discontinuation group were 11.18 and 16.97 per 1,000 person-years, respec‐ tively. Adjusted HR was not different in the two groups (0.65, 95% CI: 0.39–1.07). Prescription of OATs at least once within 90 days after initiating chemotherapy in AF patients with cancer was not significantly associated with the incidence of cardiogenic thromboembolism.
Coordinated Power Management and Control of Standalone PV-Hybrid System With Modified IWO-Based MPPT

To augment the photovoltaic (PV) power generation conversion, a maximum power point tracking (MPPT) technique plays a very significant role. This article introduces a hybrid MPPT algorithm integrating modified invasive weed optimization (MIWO) and perturb and observe (P&O) technique under the rapid weather change and partial shading scenarios for the efficient extraction of the maximum power from the standalone PV-based hybrid system. MIWO handles the initial stages of MPPT followed by the application of the P&O algorithm at the final stages in view of acquiring the rapid global peak and maximal PV power. The studied microgrid comprises of the PV system, battery, electrolyzer, fuel cell, and load. A coordinated dc-voltage regulation and power management strategy between each subsystem of the hybrid microgrid is implemented to save the battery from the undesirable charging/discharging operation. Additionally, with the monitoring of dc voltage, the dc/dc converter associated with the battery and dc link plays as an MPPT circuit of the PV without the requirement of an extra dedicated circuit. Takagi–Sugeno (TS) fuzzy controller is adopted for suppressing/mitigating the voltage oscillations of the microgrid during the variations in the solar irradiance/temperature and power demand. The results clearly exhibit the superior performance of the proposed methodology compared with some of the existing techniques.
A Scalable and Secure Publish/Subscribe-Based Framework for Industrial IoT

In the emerging industrial Internet of Things (IIoT) scenario, machine-to-machine communication is a key technology to set up environments, wherein sensors, actuators, and controllers can exchange information autonomously. However, many current communication frameworks do not provide enough dynamic interoperability and security. Hence, in this article, we propose a novel communication framework based on Message Queuing Telemetry Transport (MQTT) broker bridging, which, in an IIoT scenario, can foster dynamic interoperability across different production lines or industrial sites, guaranteeing, at the same time, a higher degree of isolation and control over the information flows, thereby increasing the overall security of the whole scenario. The solution we propose also supports dynamic authentication and authorization and has been practically implemented and evaluated in a proper small-scale IIoT testbed, encompassing PLCs, IIoT gateways, and MQTT brokers with novel and extended capabilities. The evaluation results demonstrate a linear time complexity for all the considered implementations and bridging modes of the extended brokers. Moreover, all considered access token encapsulation techniques demonstrate a minimum overhead in comparison with standard MQTT brokers.
Compliant Force Sensor-Less Capture of an Object in Orbit

Space robots have been proposed to perform several tasks in orbit, such as repairing, refueling, and assembly. All those activities require the robot to interact with external objects in a safe and compliant form to avoid high impact forces that may damage the robot's components or the object to manipulate. Impedance controllers have demonstrated to be a suitable approach to perform similar tasks in ground. Therefore, implementing and analyzing impedance-based techniques in space is also worthy of study. Not only that, but also, methods that can reduce the number of components, weight and complexity should be considered. This article proposes the use of the disturbance observer for the design of an impedance controller to perform a safe capture of a target satellite by a space robot. First, the observer aids in the determination of the contact force between the servicer and the target. Later, once the almost perfect match between the actual and estimated contact force is demonstrated, the estimated force is used as input for an impedance controller with trajectory tracking. The advantages of estimating the contact force instead of measuring it are also discussed in the document. The design of the impedance control is performed such that the capturing process is compliant and safe, and, thus, it can help to advance toward an autonomous capture of space objects. A simulation experiment was set up to evaluate the performance of the proposed method. The results demonstrate that the contact force is bounded and behaves smoothly in a spring–mass–damper-like manner, imposing a stable contact between the robot's end effector and the servicer's capturing spot.
Active Power Management of Islanded Interconnected Distributed Generation

The present paper proposes a management of active power in distributed generation considering an islanded mode. Power system is a complex system from the point of view of its constitution, operation and management. Because of energy sources scarcity and energy increasing demand in most of the electrical power systems worldwide, renewable energy exploitation continue to attract researches and exploitation of this weather depending resources. When considering the island mode or without connection to the main grid, of the distributed generation its operation and control became more difficult or uncertain based their dependencies on the weather. Using optimal theory, this paper solve the management of interconnected microgrids operating in islanded mode. Matlab software is used to solve all optimisation problems. 
Evolution of Wi-Fi Protected Access: Security Challenges

Security for Wi-Fi networks is now being upgraded to a new version, WPA3, after vulnerabilities and weaknesses in the previous versions were correctly patched. The most critical upgrades include 1) data traffics already sent remain a secret even if a preshared password of the Wi-Fi network is compromised by an adversary, and 2) weak passwords are immune to online and offline guessing attacks. This article explains in detail where in the previous versions these weaknesses originated and how in the new version they are rectified. Further, this article checks if there is still room for improvement, especially in security algorithms introduced in the new version.