Miracle-dz/UniFAR-FTUs huggingface dataset:
A feasibility study of a manualized resilience-based telehealth program for persons with multiple sclerosis and their support partners

Background Resilience is a protective factor that emerges when individuals are faced with challenges and stressors. Multiple sclerosis (MS) is a chronic neurological disease that introduces a great deal of stress for the individual and his/her support partner. We designed a telehealth resilience-building dyadic program for persons with MS (PwMS) and their support partners. Objectives To evaluate the feasibility of the resilience intervention. The secondary objective was to assess the benefits of the intervention. Methods Sixty-two participants (M = 49.5 years, 31 dyads of PwMS) and support partners) were recruited to participate. Out of the 31 dyads, 26 were spouses, 2 were cohabiting partners, and 3 were parent–child dyads. Results The feasibility goals of the intervention were met, as determined by high participant satisfaction and acceptable completion rates. Preliminary outcomes relating to resilience were positive, suggesting that this intervention had a positive impact on participants. Conclusions To the best of our knowledge, this is the first resilience-building intervention delivered via telehealth for both PwMS and their support partners. The study showed an increase in resilience-building skills for addressing the challenges faced by PwMS and their support partners. These skills can be promoted and taught, clinically supported by telehealth, an affordable, accessible healthcare solution. Trial Registration at ClinicalTrials.gov (NCT03555253).
Efficacy of postoperative drainage in total knee arthroplasty: Review of the literature

Postoperative drainage after total knee arthroplasty (TKA) is an established routine procedure for orthopedic surgeries, and is considered a useful practice in postoperative, but the use of drainage is controversial. Our study aims to clarify this aspect of knee prosthetic surgery. A systematic review of the literature was performed in the electronic databases to investigate the risks and the benefits of wound drainage in total knee arthroplasty: 30 articles were included in our review for eligibility. After the analysis of the literature performed, we found no significant advantages related with the use of wound drain following total knee replacement (TKR) in terms of pain, transfusion rate, blood loss, swelling, postoperative range of motion, wound complications, deep infection and hospital stay, while no drainage means a significant cost saving compared to drainage use. Thus, the use of drainage after TKA cannot be justified on the basis of the results of this study.
Network Pharmacology-Based Approach to Revealing Biological Mechanisms of Qingkailing Injection against IschemicStroke: Focusing on Blood-Brain Barrier

Ischemic stroke is the most common type of cerebrovascular accident worldwide. It causes long-term disability and death. Qingkailing (QKL) injection is a traditional Chinese patent medicine which has been clinically applied in the treatment of ischemic stroke for nearly thirty years. In the present study, network pharmacology combined with experimentation was used to elucidate the mechanisms of QKL. ADME screening and target prediction identified 62 active compounds and 275 targets for QKL. Topological screening of the protein-protein interaction (PPI) network was used to build a core PPI network consisting of 408 nodes and 17,830 edges. KEGG enrichment indicated that the main signaling pathway implicated in ischemic stroke involved hypoxia-inducible factor-1 (HIF-1). Experimentation showed that QKL alleviated neurological deficits, brain infraction, blood-brain barrier (BBB) leakage, and tight junction degeneration in a mouse ischemic stroke model. Two-photon laser scanning microscopy was used to evaluate BBB permeability and cerebral microvessel structure in living mice. HIF-1α, matrix metalloproteinase-9 (MMP-9), and tight junction proteins such as occludin, zonula occludins-1 (ZO-1), claudin-5, and VE-Cadherin were measured by western blotting. QKL upregulated ZO-1 and downregulated HIF-1α and MMP-9. QKL has a multiapproach, multitarget, and synergistic effect against ischemic stroke.
Assignment 1 of maltase glucoamylase (MGAM) gene to bovine chromosome 4q34 by in situ hybridization and confirmation by radiation hybrid mapping

In mammals, hydrolysis of the nonreducing ends of oligosacharide chains is carried out by an enzyme complex involving sucrase-isomaltase and maltase-glucoamylase which is anchored in the mucosa of the small intestine brush border (Semenza and Aurichino, 1989). It has been hypothesized that the human MGAM activity is an alternate pathway for starch digestion when luminal ·-amylase activity is reduced because of immaturity and malnutrition and that MGAM plays a unique role in the digestion of malted oligosaccharides (Nichols et al., 1998). The MGAM gene has been cloned and sequenced in man (AF016833) and partially sequenced in mouse (BC025509.1) Human MGAM has been mapped to human (HSA) chromosome 7 (Nichols et al., 1998), but as yet, the bovine MGAM gene has not been mapped. We used the human MGAM gene sequence to design specific primers to partially amplify the bovine gene. We report the localization of the bovine MGAM gene on bovine chromosome BTA4q34 by fluorescence in situ hybridization and radiation hybrid mapping.
Effects of oat soluble and insoluble β-glucan on 1,2-dimethylhydrazine-induced early colon carcinogenesis in mice

ABSTRACT The study is aimed at studying the effects of soluble and insoluble oat β-glucan on colon carcinogenesis in mice. One hundred and twenty male Kunming mice were divided into normal control (NC), model control (MC), high doses (100 mg/kg body weight) of soluble (H-SOG) and insoluble β-glucan (H-IOG), and low doses (50 mg/kg body weight) of soluble (L-SOG) and insoluble β-glucan (L-IOG) groups. The mice except those in the NC group were given subcutaneous injections of DMH to induce colon cancer. The bile acid content was significantly reduced but the colonic short-chain fatty acid content was enhanced (p < .05) in mice administered β-glucan, moreover, the tumor cells apoptosis was significantly promoted (p < .05), compared to the MC group. The effect of high doses β-glucan was better than the low doses, but there is little difference between the SOG and IOG. Results suggested that both SOG and IOG exert favorable effects in preventing colon cancer in a doses-dependent manner while the specific mechanism maybe different.
Reaction norms in weights at 365 days old in Nellore bulls in northern Brazil.

Genotype by environment interaction (GxE) studies are of particular interest in Brazil because of the regional diversity of environmental effects and the wide variety of management systems. The present study evaluates GxE effects on 365 d weight (365W) of Nellore cattle raised on pasture in northern Brazil. The analysis utilized random regression techniques to model the reaction norm. Fixed effects consisted of sex, contemporary group, and the covariate of age of cow at calving. The environmental gradient, defined by the concatenation of a bull and the state in which the calf was born, was modeled by second order Legendre polynomials. Direct additive genetic and residual effects were fit as random. Results showed differences in the magnitude of expression of genotype in proportion to decreasing favorability of the environment. As the environment became more unfavorable, the correlation of breeding value to different environments decreased. The correlations between the intercept and the level slope for 365W feature were of moderate magnitude, predominantly indicating the reclassification of sires in different environments. Reaction standard model was coherent from a technical and biological view point and enabled the perception of GxE in the genetic evaluation of Nellore cattle in the states of Maranhao, Para and Tocantins.
Effect of production process and high-pressure processing on viability of Salmonella spp. in traditional Italian dry-cured coppa

The aim of the study was to investigate the combined effect of the manufacturing process followed by HPP treatment on the inactivation of Salmonella spp. in artificially contaminated coppa samples, in order to verify the ability of the combined processes to achieve the objective of a 5-log reduction of Salmonella spp. needed for exportation to the U.S. Fresh anatomical cuts intended for coppa production were supplied by four different delicatessen factories located in Northern Italy. Raw meat underwent experimental contamination with Salmonella spp. using a mixture of 3 strains. Surface contamination of the fresh anatomical cuts was carried out by immersion into inoculum containing Salmonella spp. The conditions of the HPP treatment were: pressure 593 MPa, time 290 seconds, water treatment temperature 14°C. Surface and deep samples were performed post contamination (T0), end of the cold phase (T1), end of process (Tend), and after HPP treatment (postHPP) and Salmonella spp. Enumerated. The results of this study show a significant reduction of Salmonella spp. all through the production process (P<0.01) for all companies, followed by an additional reduction of bacterial counts due to HPP treatment (P<0.01), both in superficial and deep contaminations (P<0.01). The superficial overall reduction resulted of 1.58 to 5.04 log CFU/g during the production process. HPP treatment resulted in a significant (P<0.01) superficial and deep decrease in Salmonella spp. enumeration varying from 0.61 to 4.01 log and from 1.49 to 4.13 log. According to the data presented in this study, only the combined approach of coppa manufacturing process followed by HPP treatment always led to a 5-log reduction of Salmonella spp. required by USDA/FSIS guidelines.
Environmental influences on bamboo Bashania fangiana growth and implications for giant panda conservation

BY DONALD G. REID*? , ALAN H. TAYLORt, HU JINCHUI AND QIN ZISHENG* * Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada and WWF-International, CH-1196 Gland, Switzerland; t Department of Geography, Pennsylvania State University, University Park, PA 16802, U.S.A. ; and t Department of Biology, Nanchong Normal College, Nanchong, Sichuan, People's Republic of China
The Mechanisms of Atmospheric Oxidation of the Alkenes

I. Importance of Alkanes in Atmospheric Chemistry of the Urban, Regional, and Global Scales II. Reactions of Alkanes with the Hydroxy Radical (OH) III. Kinetics and Mechanisms of Reactions of Cl, O(3P), NO3, and O3 with Alkanes IV. Mechanisms and End-Products of the Atmospheric Oxidation of Alkanes V. Reactions of Products of Alkane Reactions VI. Atmospheric Chemistry of the Haloalkanes VII. The Primary Photochemical Processes in the Alkanes, Haloalkanes, and Some of Their Oxidation Products VIII. Representation of the Atmospheric Chemistry of Alkanes in Models References
Wing and Tail Molt of the Sparrow Hawk

IN the order Falconiformes, the family Falconidae is unique in that the molt of the primaries begins with the fourth primary and proceeds imultaneously in both directions (Stresemann, 1958; Stresemann and Stresemann, 1960). Mebs (1960) studied the wing and tail molt sequences in several species of large falcons and concluded that these molt sequences served as additional proof that the Lanner Falcon (Falco biarmicus), Sakar Falcon (F. cherrug), Prairie Falcon (F. mexicanus), and Gyrfalcon (F. rusticolus) are more closely related to each other than to the Peregrine Falcon (F. peregrinus). Wing and tail molt sequences have not been described in detail for the Sparrow Hawk, or American Kestrel (F. sparverius), although Parkes (1955) and Roest (1957: 10) discussed its molts and plumages. Since the molt sequence of remiges and rectrices may be useful as a taxonomic tool, this paper describes wing and tail molt sequences of 13 captive Sparrow Hawks.
DEFINING AND DEMONSTRATING POSTCOPULATORY FEMALE CHOICE–AGAIN

My motivation for writing about the criteria for detecting one form of cryptic female choice, female sperm choice (Birkhead 1998) was twofold: to stimulate discussion (which has occurred) and to draw attention to the fact that novel ideas need to be subject to rigorous testing. There are many different styles of conducting science, one is that it is sufficient to generate novel ideas; at the other end of the continuum is the view, which coincides with my own, that unless an idea has been subject to rigorous testing, its value is limited. To some extent, my conviction that new hypotheses should be subject to testing arises from the impression that in the field of behavioral ecology there is an increasing trend for researchers to feel that it is sufficient to generate interesting ideas, to accept circumstantial evidence, or to report only that evidence which is consistent with a favorite hypothesis. In turn, this change in attitude may be partly a consequence of an increasingly competitive academic climate (e.g., Maddox 1993; Woodward and Goodstein 1996) in which there is little incentive and insufficient time to test ideas properly or replicate the experiments of others, particularly in fields with little impact on the quality of human life. Cryptic female choice is a form of sexual selection and part of behavioral ecology (Krebs and Davies 1997). Behavioral ecology has been a particularly successful area of research and, as is typical of many young sciences, ideas often outstripped data, particularly in its early days. Although most of its practitioners would probably agree that behavioral ecology is now in a phase of more ‘‘normal science’’ (Kuhn 1970) much of the early enthusiasm still remains—especially for novel ideas, recent examples of which include: fluctuating asymmetry, immunocompetence, and cryptic female choice. I regard novel ideas as crucial starting points for progress, but they are not an end in themselves and to make genuine progress we need firm foundations on which to build. A combination of novel ideas, subsequently tested by the most rigorous methods available, including replication, provide the best recipe for success. Behavioral ecologists as a whole have not been especially good about this. A common excuse for the lack of replication for example, apart from the difficulty of obtaining funding for this purpose, is that biology is complex and replication is technically difficult, particularly with studies conducted in the field. However, cryptic female choice, because of its more mechanistic nature, lends itself to careful experimentation and replication more readily than other areas of behavioural ecology, once methods for identifying it have been agreed upon. As soon as we have some sound methodology in place, we will be in a position to fully assess the importance of cryptic female choice in evolution. Here I respond to comments made by three sets of authors in response to my suggestions for how we might seek to identify one form of cryptic female choice: female sperm choice (Birkhead 1998).
Hybridization and speciation in the Yellow-rumped Warbler complex

ii Table of contents. iii List of tables . v List of figures. vi Acknowledgements . vii Co-authorship statement. viii CHAPTER 1: General introduction . 1 CHAPTER 2: Incipient speciation despite little assortative mating: the Yellowrumped Warbler hybrid zone . 7 2.
Hybrid Security Framework based on Biometrics Features

— In most information systems, security is one of the important aspects that consider when design the system. In transferring data, ensuring that the data is delivered to the recipient with confidentiality, by applying security methods. More than one algorithm is used to encrypt information in order to increase protection and reduce vulnerabilities. In this paper we present a design and implementation of system that use biometric technique in addition to hybrid encryption algorithms which are (AES, TDES). By using finger vein authentication and variant key selection to enhance the security and increased the complexity.
Fundamental Considerations of Measurement, Analysis and Interpretation in Designing Performance Recording Systems in Animals

In traditional husbandry the measurement of production has played little part, with assessment of animals usually being made by subjective evaluation of performance. Such evaluation may be fairly accurate when flocks or herds are small and closely supervised because under such conditions individual animals are very well known to the people concerned. However, when groups of animals are too large or husbandry systems are not suitable for detailed individual knowledge of animal performance, measurement provides the only possibility for comparison among different animals or groups. Measurement is particularly important when animals are to be compared and the animals involved are not all known by those who must make decisions on choices between them. Even when there is good personal knowledge of animals in a particular population, that knowledge may not be generally available and may not be in a form convenient for analysis of differences in profitability of various management procedures or for planning breeding programs. Therefore even in low or medium input farming systems it may be desirable to institute performance recording in order to improve general management or genetic improvement.
Deciphering Public Opinion of Nuclear Energy on Twitter

This paper explores nuclear energy-related Twitter discussions as a response to the 2011 Fukushima Nuclear Disaster and the 2017 Nobel Peace Prize won by the International Campaign to Abolish Nuclear Weapons. We have considered a total of 2 million tweets for these two events. In particular, we employed CNN, LSTM, and Bi-LSTM to investigate whether social media users are supportive or cynical about nuclear energy. Our AI algorithms have performed better for polarity detection (accuracy in the range of 90%) with respect to subjectivity detection (accuracy in the range of 75%). We also note that dominant aspects of supporting tweets revolve around concepts like clean energy, lower CO2 emission, and sustainable future. On the contrary, cynical users see nuclear energy as a threat to the environment, human life, and safety.
Molecular Identification and Antimicrobial Potential of Streptomyces Species from Nepalese Soil

Streptomyces are widely used for the production of secondary metabolites with diverse biological activities, including antibiotics. The necessity of alternative antimicrobial agents against multidrug-resistant pathogens is indispensable. However, the production of new therapeutics is delayed in recent days. Thus, the isolation of new Streptomyces species has drawn attention. Nepal—a country rich in biodiversity—has got high possibilities for the discovery of members of actinomycetes, especially in the higher altitudes. However, in vain, only a few screening research works have been reported from Nepal to date. Streptomyces species were isolated on ISP4 media, and characterization was performed according to morphological similarity and 16S rRNA sequence similarity using bioinformatic tools. Ethyl acetate extracts of Streptomyces species were prepared, and the antimicrobial activity was carried out using agar well diffusion technique. In this report, 18 Streptomyces species isolated from the soil were reported based on sequence analysis of 16S rRNA. Among them, 12 isolates have shown antibacterial activity against extended-spectrum beta-lactamase- (ESBL-) producing Escherichia coli. Here, we have also analyzed 16S rRNA in 27 Streptomyces species whose whole-genome sequence is available, which has revealed that some species have multiple copies of the 16S gene (∼1.5 kb) with significant variation in nucleotides. In contrast, some Streptomyces species shared identical DNA sequences in multiple copies of 16S rRNA. The sequencing of numerous copies of 16S rRNA is not necessary, and the molecular sequencing of this region is not sufficient for the identification of bacterial species. The Streptomyces species-derived ethyl acetate extracts from Nepalese soil demonstrate potential activity against ESBL-producing E. coli. Thus, they are potential candidates for antibiotics manufacturing in the future.
An integrative microenvironment approach for follicular lymphoma: roles of inflammatory cell subsets and immune-response polymorphisms on disease clinical course

The study of the tumor microenvironment (TME) in follicular lymphoma (FL) has produced conflicting results due to assessment of limited TME subpopulations, and because of heterogeneous treatments among different cohorts. Also, important genetic determinants of immune response, such as single-nucleotide polymorphisms (SNPs), remain underexplored in this disease. We performed a detailed study of the TME in 169 FL biopsies using immunohistochemistry, encompassing lymphocytes, macrophages, and cytokines. We also genotyped 16 SNPs within key immune-response genes (IL12A, IL2, IL10, TGFB1, TGFBR1, TGFBR2, IL17A, and IL17F) in 159 patients. We tested associations between SNPs, clinicopathological features and TME composition, and proposed survival models in R-CHOP/R-CVP-treated patients. Presence of the IL12A rs568408 “A” allele associated with the follicular pattern of FOXP3+ cells. The IL12A AA haplotype included rs583911 and rs568408 and was an independent predictor of worse survival, together with the follicular patterns of T-cells (FOXP3+ and CD8+) and high IL-17F tumor levels. The patterns of CD3+, CD4+ and CD8+ cells, displayed as a principal component, also associated with survival. Hierarchical clustering of the TME proteins demonstrated a cluster that was associated with worse prognosis (tumors enriched in IL-17A, IL-17F, CD8, PD1, and Ki-67). The survival of FL patients who were treated in the rituximab era shows a strong dependence on TME signals, especially the T-cell infiltration patterns and IL-17F tumor levels. The presence of the AA haplotype of IL12A in the genome of FL patients is an additional prognostic factor that may modulate the composition of T-reg cells in this disease.
Comprehensive Characterization of Prognostic Long Noncoding RNAs in Osteosarcoma

The molecular mechanism of osteosarcoma (OS) based on protein-coding genes has largely been studied in the past decades. However, much remains to be explored when it comes to the role that long noncoding RNAs (lncRNAs) play in the pathogenesis and progression of OS and how they are associated with OS metastasis. In the present study, we collected RNA-seq-based gene expression data of 82 OS samples from the Therapeutically Applicable Research To Generate Effective Treatments (TARGET) database, along with their clinical information. We found that 50 lncRNAs were significantly associated with patients' survival by univariable Cox regression model. Moreover, we built multivariable Cox regression model based on 7 lncRNAs and successfully stratified patients into two risk groups, which exhibited significantly different prognostic outcomes. Significantly enriched Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways detected by differential expression analysis on DEGs between the two groups with different prognostic outcomes were both immune-related, indicating that such GO terms and pathways are critical for OS survival. Among the seven lncRNA signatures, AC011442.1 was predicted to act as an oncogenic driver in OS by correlation analysis of copy number alteration (CNA) and lncRNA expression, and it was predicted to regulate AMPK and hedgehog signaling pathways. In summary, the identification of novel prognostic lncRNAs in OS could not only improved our understanding of the lncRNAs involved in OS tumorigenesis or progression but also assist the diagnosis and development of molecularly targeted therapies for OS, which in turn benefit patients' survival.