Miracle-dz/UniFAR-FTUs huggingface dataset:
Top-k Keyword Search over Wikipedia-based RDF Knowledge Graphs

Effective keyword search over RDF knowledge graphs is still an ongoing endeavor. Most existing techniques have their own limitations in terms of the unit of retrieval, the type of queries supported or the basis on which the results are ranked. In this paper, we develop a novel retrieval model for general keyword queries over Wikipedia-based RDF knowledge graphs. Our model retrieves the top-k scored subgraphs for a given keyword query. To do this, we develop a scoring function for RDF subgraphs and then we deploy a graph searching algorithm that only retrieves the top-k scored subgraphs for the given query based on our scoring function. We evaluate our retrieval model and compare it to state-of-the-art approaches using YAGO, a large Wikipedia-based RDF knowledge graph.
Reversible Manipulation of Telomerase Expression and Telomere Length

Most human cells do not express telomerase and irreversibly arrest proliferation after a finite number of divisions (replicative senescence). Several lines of evidence suggest that replicative senescence is caused by short dysfunctional telomeres, which arise when DNA is replicated in the absence of adequate telomerase activity. We describe a method to reversibly bypass replicative senescence and generate mass cultures that have different average telomere lengths. A retrovirus carrying hTERTflanked by excision sites for Cre recombinase rendered normal human fibroblasts telomerase-positive and replicatively immortal. Superinfection with retroviruses carrying wild-type or mutant forms of TIN2, a negative regulator of telomere length, created telomerase-positive, immortal populations with varying average telomere lengths. Subsequent infection with a Cre-expressing retrovirus abolished telomerase activity, creating mortal cells with varying telomere lengths. Using these cell populations, we show that, afterhTERT excision, cells senesce with shorter telomeres than parental cells. Moreover, long telomeres, but not telomerase, protected cells from the loss of division potential caused by ionizing radiation. Finally, although telomerase-negative cells with short telomeres senesced after fewer doublings than those with long telomeres, telomere length per se did not correlate with senescence. Our results support a role for telomere structure, rather than length, in replicative senescence.
Vibrio vulnificus Biotype 2 Serovar E gne but Not galE Is Essential for Lipopolysaccharide Biosynthesis and Virulence

ABSTRACT This work aimed to establish the role of gne (encoding UDP-GalNAc 4-epimerase activity) and galE (encoding UDP-Gal-4-epimerase activity) in the biosynthesis of surface polysaccharides, as well as in the virulence for eels and humans of the zoonotic serovar of Vibrio vulnificus biotype 2, serovar E. DNA sequence data revealed that gne and galE are quite homologous within this species (≥90% homology). Mutation in gne of strain CECT4999 increased the surface hydrophobicity, produced deep alterations in the outer membrane architecture, and resulted in noticeable increases in the sensitivity to microcidal peptides (MP), to eel and human sera, and to phagocytosis/opsonophagocytosis. Furthermore, significant attenuation of virulence for eels and mice was observed. By contrast, mutation in galE did not alter the cellular surface, did not increase the sensitivity to MP, serum, or phagocytosis, and did not affect the virulence for fish and mice. The change in the attenuated-virulence phenotype produced by a mutation in gne was correlated with the loss of the O-antigen lipopolysaccharide (LPS), while the capsule was maintained. Complementation of a gne-deficient mutant restored the LPS structure together with the whole virulence phenotype. In conclusion, gne, but not galE, is essential for LPS biosynthesis and virulence in the zoonotic serovar of V. vulnificus biotype 2.
Preparation of highly specific polyclonal antibody for human zinc transporter ZIP8.

进细胞质[2 ] 。 ZIP8 被屏蔽被 BCG-CWS (杆菌 Calmette-Guerin 房间墙骨骼) 高度导致的 cDNA 原来在主要单核白血球识别[3 ] 。 自从它的第一发现， ZIP8 被发现了仔细在象 T 房间激活和天生的免疫那样的免疫系统被含有。 ZIP8 也是描绘得好的镉(Cd ) transporter，在 vitro 并且在 vivo 实验由两个示威了[4,5 ] 。 象另外的压缩一样[6,7 ] ， dimerization 和 glycosylation 的各种各样的度在 ZIP8 上被观察了[2 ] 。 因此，在不同条件下面内长的 ZIP8 变化检测表示，高度特定的 anti-ZIP8 抗体被需要。 在这研究，我们开发了新策略用作为 immunogen 包含人的 ZIP8 蛋白质和 GST 的 N 终端区域的肽产生 polyclonal anti-ZIP8 抗体。 在我们的实验室产生的产生抗血清为由 ELISA 示威了的 ZIP8 察觉高度有效、特定，西方的弄污，并且染色的 immunofluorescent。 生产 anti-ZIP8 抗体， ZIP8 N 终端区域的开始的 100 氨基酸，包含了更多的 B 房间 epitopes 并且与另外的压缩显示出更少的相同，为抗体生产被选择为 immunogen 的部分(图 ? 1 ) 。 GST-hZIP8 (100aa ) 熔化蛋白质在包括身体被表示，有 sarkosyl 和 refolded 的 solubilized 面对三重氢核 X-100 和小伙子(增补微量。 S1 和 S2A ) 。 为从包括身体净化 GST 熔化蛋白质的这个方法被道等描述。 [8 ] 。 它值得提及那正在增加 GSH elution 的 pH
Enterprise Resource Planning (ERP) Competence Constructs: Two-Stage Multi-Item Scale Development and Validation

This paper defines and operationalizes eight ERP competence constructs. We define ERP competence as a portfolio of managerial, technical and organizational skills and expertise posited as antecedents to improved business performance occurring after an ERP system is operational and functionally stable. To improve responses to changes in markets and products, manufacturers are increasingly adopting ERP systems. However, anecdotal accounts indicate that the realization of ERP's potential benefits is rare. Because of its pervasive influence on manufacturing and business performance, the need for scientifically developed and tested multi-item scales pertaining to ERP competence is highly relevant to manufacturing strategy research. We follow a two-stage normative process of scale development. First, we identify a portfolio of eight generic constructs that are hypothesized to be associated with successful ERP adoption. Each construct is then operationalized as a multi-item measurement scale by applying a manual item sorting technique iteratively to independent panels of expert judges until tentative reliability and validity is established. Second, we further refine and validate the multi-item scales using survey data from 79 North American manufacturing users of ERP systems.
Z Providing Geo-Elasticity in Geographically Distributed Clouds

Geographically distributed cloud platforms are well suited for serving a geographically diverse user base. However traditional cloud provisioning mechanisms that make local scaling decisions are not adequate for delivering best possible performance for modern web applications that observe both temporal and spatial workload fluctuations. In this paper, we propose GeoScale, a system that provides geo-elasticity by combining model-driven proactive and agile reactive provisioning approaches. GeoScale can dynamically provision server capacity at any location based on workload dynamics. We conduct a detailed evaluation of GeoScale on Amazon’s geo-distributed cloud, and show up to 40% improvement in the 95th percentile response time when compared to traditional elasticity techniques.
Animal models of psychopathology: Historical models and the pavlovian contribution

La investigacion con animales no humanos como sujetos experimentales, para entender el comportamiento humano, se basa en la nocion darwiniana de la continuidad de las especies. En este marco encontramos modelos analogos para entender la biologia y el comportamiento humanos en especies no humanas. En psicologia, los modelos animales han probado ser una herramienta efectiva para el entendimiento del comportamiento humano, tanto normal como anormal. En la presente revision discutimos como los modelos animales han sido usados al investigar la psicopatologia. Luego de revisar tres modelos animales historicos de psicopatologias especificas, discutimos como los fenomenos descubiertos al estudiar el condicionamiento pavloviano han contribuido a nuestra comprension de la etiologia y mantencion de la psicopatologia humana, como la tradicion pavloviana ha contribuido al desarrollo de mejores formas de tratamiento para desordenes del comportamiento, y de forma mas general, como los fenomenos pavlovianos se encuentran implicados en casi todas las interacciones entre un organismo y su ambiente.
Remote communication support system as communication catalyst for dementia care

In this paper we describe a prototype remote communication support system to be used as a communication catalyst for dementia care. The system aims to delay the progression of dementia and helps caregivers by facilitating the social interaction of dementia patients. In the system framework, a video telecommunication system was installed in order to enable communication between patients and caregivers. Next, a system control board was designed to maintain robust operation so that users could connect with each other anytime. In the system, we also implemented a reminiscence based therapy application to prevent the progression of dementia. The application can show old photos to dementia patients during a typical video chat. From the caregivers' point of view, our system is also an important form of assistance for repeating announcements and instructions to dementia patients with poor memory. Accordingly, we also made a video replay application which can be set to replay video at a fixed time everyday. Finally, we made aesthetically pleasing robots that serve to make interaction with the system more natural for dementia patients.
Maternal Obesity: Can Pregnancy Weight Gain Modify Risk of Selected Adverse Pregnancy Outcomes?

Reports by the Institute of Medicine (IOM) recommend that gestational weight gain goals should be modified according to prepregnancy body mass index (BMI), which could result in better maternal and infant outcomes. The authors assessed whether the risk of the pregnancy outcomes such as rate of cesarean section to primiparous and multiparous women, macrosomia, and breastfeeding at 10 weeks postpartum can be modified by following the IOM guidelines for gestational weight gain irrespective of prepregnancy BMI. Staff from the New Jersey Pregnancy Risk Assessment Monitoring System interviewed a sample of women who delivered live births in New Jersey during 2002 through 2005 (n = 7661). In New Jersey, 18% of mothers were obese, 13% were overweight, and 16% were underweight. In logistic regression analyses, after controlling for maternal characteristics, the effect of prepregnancy obesity and weight gain more than 34 lb independently and significantly increased the risk of all four adverse outcomes. For no outcomes was the 25- to 34-pound weight gain category significantly distinguishable from the 16- to 24-pound reference category. These results strongly support the idea that the IOM weight gain recommendation (education during preconception regarding the importance of optimal BMI at the start of pregnancy) will help to achieve better pregnancy outcomes in obese and overweight women.
Phytochemical screening and analgesic profile of the lyophilized aqueous extract obtained from Chrysobalanus icaco leaves in experimental protocols

Abstract Context: Chrysobalanus icaco L. (Chrysobalanaceae) has been used for the treatment of abdominal pain and cramps. Objective: Assess the chemical and pharmacological profile of the lyophilized aqueous extract from C. icaco leaves (AEC). Materials and methods: Chromatographic methods were used to assess compounds from AEC. Mice were treated with vehicle (control group) or AEC (100, 200 or 400 mg/kg, p.o.) (group with 7–8 mice) and the analgesic profile was assessed employing the acetic acid-induced writhing, formalin, hot plate tests and hyperalgesia induced by carrageenan (CG) or tumour necrosis factor-alpha. The animal motor performance was assessed using rota-rod and grip strength tests. Results: The chromatographic profile of AEC demonstrated the presence of terpenoid compounds. The acute pretreatment with AEC, at all doses, produced a significant (p < 0.01) inhibition of painful bahaviour (11.4 ± 3.6; 10.3 ± 2.8; 11.3 ± 2.2) when compared to the control group (24.7 ± 4.7) in acetic acid-induced writhing test. In the formalin test, AEC were effective in the second phase (p < 0.01) (57.2 ± 10.3; 56.3 ± 9.2; 54.7 ± 8.9) when compared to control group (121.9 ± 18.5). No response was observed in the hot plate test. The higher dose of AEC produced a significant (p < 0.01 or p < 0.05) inhibitory effect on the mechanical hyperalgesia test. AEC did not affect the motor performance of the mice. Discussion: The terpenoids from AEC are known for its analgesic and anti-inflammatory properties. So, these results corroborate the experiments using the AEC in inflammatory pain protocols. Conclusion: Our results suggest that AEC act against inflammatory pain.
[Identification of binding proteins to the PDZ domain of ERBIN].

OBJECTIVE To identify the binding proteins to PDZ domain of ERBIN. METHODS Using PDZ domain of ERBIN as the bait, yeast two-hybrid technology was employed to screen the human lymphocyte leukemia cells MATCHMAKER cDNA library. The protein interaction was identified by immunoprecipitation. RESULTS A PDZ-binding protein, TAX1, was identified. CONCLUSION TAX1 is a novel binding protein to PDZ domain of ERBIN.
Incorporating Intra‐Query Term Dependencies in an Aspect Query Language Model

Query language modeling based on relevance feedback has been widely applied to improve the effectiveness of information retrieval. However, intra‐query term dependencies (i.e., the dependencies between different query terms and term combinations) have not yet been sufficiently addressed in the existing approaches. This article aims to investigate this issue within a comprehensive framework, namely the Aspect Query Language Model (AM). We propose to extend the AM with a hidden Markov model (HMM) structure to incorporate the intra‐query term dependencies and learn the structure of a novel aspect HMM (AHMM) for query language modeling. In the proposed AHMM, the combinations of query terms are viewed as latent variables representing query aspects. They further form an ergodic HMM, where the dependencies between latent variables (nodes) are modeled as the transitional probabilities. The segmented chunks from the feedback documents are considered as observables of the HMM. Then the AHMM structure is optimized by the HMM, which can estimate the prior of the latent variables and the probability distribution of the observed chunks. Our extensive experiments on three large‐scale text retrieval conference (TREC) collections have shown that our method not only significantly outperforms a number of strong baselines in terms of both effectiveness and robustness but also achieves better results than the AM and another state‐of‐the‐art approach, namely the latent concept expansion model. © 2014 Wiley Periodicals, Inc.
University of Southern Denmark Identification of sex-specific DNA methylation changes driven by specific chemicals in cord blood in a Faroese birth cohort

Background: Faroe islanders consume marine foods contaminated with methylmercury (MeHg), polychlorinated biphenyls (PCBs), and other toxicants associated with chronic disease risks. Differential DNA methylation at specific CpG sites in cord blood may serve as a surrogate biomarker of health impacts from chemical exposures. Objective: We aimed to identify key environmental chemicals in cord blood associated with DNA methylation changes in a population with elevated exposure to chemical mixtures. Method: We studied 72 participants of a Faroese birth cohort recruited between 1986 and 1987 and followed until adulthood. The cord blood DNA methylome was profiled using Infinium Methylation 450K BeadChips. We determined the associations of CpG site changes with concentrations of MeHg, major PCBs, other organochlorine compounds, (hexachlorobenzene [HCB], p,p’-dichlorodiphenyldichloroethylene [p,p’-DDE] and p,p’dichlorodiphenyltrichloroethane) and perfluoroalkyl substances. Results: In a combined sex analysis, among the 16 chemicals studied, PCB congener 105 (CB105) exposure was associated with the majority of differentially methylated CpG sites (214 out of a total of 250). In female-only-analysis, only 73 CB-105 associated CpG sites were detected, 44 of which were mapped to genes in the ELAV1-associated cancer network. In males-only, methylation changes were seen for perfluorooctane sulfonate, HCB, and p,p’-DDE in 10,598; 1,238; and 1,473 CpG sites, respectively, 15% of which were enriched in cytobands of the X chromosome associated with neurological disorders. Conclusion: In this multiple-pollutant and genome-wide study, we identified key epigenetic toxicants. The significant enrichment of specific X-chromosome sites in males implies potentially sex-specific epigenome responses to prenatal chemical exposures.
Can auditory icons induce food intake mimicry

This research hypothesized that auditory icons that represent eating can be used to induce mimicry in food intake behavior.Numerous studies show that, when two people are eating together, they mimic each other’s eating behavior.To test this hypothesis, participants were asked to eat diced apples.While eating, they can hear auditory icons that represent other people’s eating sound.In reality, the auditory icons used were a sound loop.Their food intake was monitored. If eating occurred within 5 seconds after the participants heard the auditory icons, they were considered to mimic the sound.It was found that, auditory icons that represent eating cause food intake mimicry in human.In the future, results gained from this research may be applied in the design and development of persuasive technology to persuade people to eat slowly since it is beneficial to health.
Phase Models to Control Roughness in Additive Synthesis

This paper introduces the concepts of auditory roughness and perceptual dissonance. Using a computational auditory model, roughness prediction results are computed and analyzed. It is concluded that auditory roughness and perceptual dissonance theories result in comparable predictions f r steady state sounds, except in special cases where the phase of partials are of importance. Utilizing these findings, a sy nthesis algorithm for the adjustment of roughness in musical sounds is proposed and implemented. The algorithm is based on additive synthesis. Informal listening tests suggest a r elation between the control parameter of this algorithm and the pleasantness of the resulting sounds.
Accelerated -Greedy Multi Armed Bandit Algorithm for Online Sequential-Selections Applications

Current algorithms for solving multi-armed bandit (MAB) problem in stationary observations often perform well. Although this performance may be acceptable with accurate parameter settings, most of them degrade under non stationary observations. We setup an incremental e-greedy model with stochastic mean equation as its action-value function which is more applicable to real-world problems. Unlike the iterative algorithms suffering from step size dependency, we propose an adaptive step-size model (ASM) to introduce adaptive MAB algorithm. The proposed model employs e-greedy approach as action selection policy. In addition, a dynamic exploration parameter e is introduced to be ineffective by increasing decision maker's intelligence. The proposed model is empirically evaluated and compared with existing algorithms including the standard e-greedy, Softmax, e-decreasing and UCB-Tuned models under stationary as well as non stationary situations. ASM not only addresses concerns in parameter dependency problem but also performs either comparable or better than mentioned algorithms. Applying these enhancements to the standard e-greedy reduce the learning time which is more attractive to the wide range of on-line sequential selection-based applications such as autonomous agents, adaptive control, industrial robots and forecasting trend problems in management and economics domains.
An evolutionary approach for non-uniform coverage control in wireless sensor networks

Most of the applications deployed over WSNs require strong coverage requirements, especially those related to the detection and tracking of distributed events. Int this paper, we use the Voronoi partition of the monitored zone to formulate and solve an evolutionary optimization problem modeling the activation of the deployed sensors. We adapt the spatial sensor distribution to the local probability of target presence. We show, through the results of our experiments, that our method allows a non-uniform deployment of the sensor nodes, which is better suitable for tracking applications.
Infrared deflectometry for the inspection of diffusely specular surfaces

Abstract Deflectometry is a full-field gradient technique that lends itself very well to testing specular surfaces. It uses the geometry of specular reflection to determine the gradient of the surface under inspection. In consequence, a necessary precondition to apply deflectometry is the presence of at least partially specular reflection. Surfaces with larger roughness have increasingly diffuse reflection characteristics, making them inaccessible to usual deflectometry. However, many industrially relevant surfaces exist that change their reflection characteristic during production and processing. An example is metal sheets that are used as car body parts. Whereas the molded but otherwise raw metal sheets show a mostly diffuse reflection without sufficient specular reflection, the final car body panels have a high specular reflectance due to the lacquering. In consequence, it would be advantageous to apply the same inspection approach both for the raw material and for the final product. To solve this challenge, specular reflection from rough surfaces can be achieved using light with a larger wavelength, as the specular reflectivity of a surface depends on the ratio of the surface roughness and the wavelength of the light applied. Wavelengths in the thermal infrared range create enough specular reflection to apply deflectometry on many visually rough metal surfaces. This contribution presents the principles of thermal deflectometry, its special challenges, and illustrates its use with examples from the inspection of industrially produced surfaces.
Factor Structure and Psychometric Properties of the Italian Version of the Homosexuality Scale of the Trueblood Sexual Attitudes Questionnaire

ABSTRACT The aim of the present study was to translate the Homosexuality scale of the Trueblood Sexual Attitudes Questionnaire into the Italian language and to assess its factor structure and psychometric properties in Italian psychology students. The questionnaire was originally developed and validated in U.S. college students, and later in Turkish social work students, showing high internal consistency. It measures attitudes toward several sexual practices and behaviors, regarding self and others. Particularly, the Homosexuality scale measures attitudes toward different sexual and romantic practices with people of the same sex. A total of 199 Italian psychology students participated to the study, and they were administered the Italian translation of the scale. We applied exploratory factor analysis and confirmatory factor analysis. Results showed that the scale has high internal consistency, and that the original two-factor model accounting for attitudes toward self and others fits the data well. Implications for education and assessment in student populations are discussed.