Miracle-dz/UniFAR-FTUs huggingface dataset:
Evolutionary conservation of nested MIR159 structural microRNA genes and their promoter characterization in Arabidopsis thaliana

MicroRNAs (miRNAs) are endogenous small RNAs, that are vital for gene expression regulation in eukaryotes. Whenever a pri-miRNA precursor includes another miRNA precursor, and both of these precursors may generate independent, non-overlapping mature miRNAs, we named them nested miRNAs. However, the extent of nested miR159 structural evolutionary conservation and its promoter characterization remains unknown. In this study, the sequence alignment and phylogenetic analysis reveal that the MIR159 family is ancient, and its nested miR159 structures are evolutionary conserved in different plant species. The overexpression of ath-MIR159a, including the 1.2 kb downstream region, has no effect on rescuing the mir159ab phenotype. The promoter truncation results revealed that the 1.0 kb promoter of ath-MIR159a is sufficient for rescuing the mir159ab phenotype. The cis-regulatory elements in the ath-miR159a promoters indicated functions related to different phytohormones, abiotic stresses, and transcriptional activation. While the MybSt1 motif-containing region is not responsible for activating the regulation of the miR159a promoter. The qRT-PCR results showed that overexpression of ath-MIR159a led to high expression levels of miR159a.1–5 and miR159a.1–3 and complemented the growth defect of mir159ab via downregulation of MYB33 and MYB65. Furthermore, continuously higher expression of the miR159a.2 duplex in transgenic lines with the curly leaf phenotype indicates that miR159a.2 is functional in Arabidopsis and suggests that it is possible for a miRNA precursor to encode several regulatory small RNAs in plants. Taken together, our study demonstrates that the nested miR159 structure is evolutionary conserved and miRNA-mediated gene regulation is more complex than previously thought.
Subcellular trafficking and post-translational modification regulate PIN polarity in plants

Auxin regulates plant growth and tropism responses. As a phytohormone, auxin is transported between its synthesis sites and action sites. Most natural auxin moves between cells via a polar transport system that is mediated by PIN-FORMED (PIN) auxin exporters. The asymmetrically localized PINs usually determine the directionality of intercellular auxin flow. Different internal cues and external stimuli modulate PIN polar distribution and activity at multiple levels, including transcription, protein stability, subcellular trafficking, and post-translational modification, and thereby regulate auxin-distribution-dependent development. Thus, the different regulation levels of PIN polarity constitute a complex network. For example, the post-translational modification of PINs can affect the subcellular trafficking of PINs. In this review, we focus on subcellular trafficking and post-translational modification of PINs to summarize recent progress in understanding PIN polarity.
Impact of different levels of zinc and nitrogen on growth, productivity, and quality of aromatic rice cultivated under various irrigation regimes in two districts of Pakistan

Rice is a staple food for more than 50% of the global population and it is one of the most valuable cereal crops. To fulfill the dietary requirement of the ever-growing world population, an increase in per-unit production of rice is direly required. In Pakistan, it stands as the 2nd in consumption after wheat, which is a staple food. A huge gap is observed between yield potential and actual yield of the aromatic rice cultivars at a farmer-field level. The significant limitations responsible for this gap are shortage of irrigation water, inappropriate application of fertilizers, less plant population, deficiency of micronutrients, and improper and poor plant protection measures. A field study was planned to assess the yield response and quality attributes of aromatic rice to three levels of zinc (Zn) and nitrogen (N) under three irrigation regimes (8-, 12-, and 16-acre inches) in the Sheikhupura and Sargodha districts of Pakistan. Irrigation treatments significantly influenced the growth, yield, and quality attributes; however, maximum improvement was observed by the application of irrigation at 12-acre inches. Among the Zn treatments, application of Zn at 10 kg ha–1 was observed to be more responsive to improving the growth and quality parameters of aromatic rice crops. In the case of N treatments, application of N at 140 kg ha–1 produced the maximum total tillers, as well as productive tillers per hill, spikelets per panicle, leaf area index, leaf area duration, crop growth rate, total dry matter, harvest index, kernel length, kernel width, and 1,000-kernel weight. Application of N at 140 kg ha–1 not only improved the growth attributes but also increased the net assimilation rate, photosynthetically active radiation, and radiation use efficiency, with respect to total dry matter and kernel yield. The maximum percentage of normal kernels and minimum percentage of opaque, abortive, and chalky kernels were also recorded by application of N at 140 kg ha–1. The outcomes of current experiments depicted that application of irrigational water, zinc, and nitrogen at 12-acre inches, 10, and 140 kg ha–1, respectively, are responsible to achieve maximum resource utilization efficiency, along with increased yield and quality of rice.
A Method for Distributed Control of Reactive Power and Voltage in a Power Grid: A Game-Theoretic Approach

The efficiency of a power system is reduced when voltage drops and losses occur along the distribution lines. While the voltage profile across the system buses can be improved by the injection of reactive power, increased line flows and line losses could result due to uncontrolled injections. Also, the determination of global optimal settings for all power-system components in large power grids is difficult to achieve. This paper presents a novel approach to the application of game theory as a method for the distributed control of reactive power and voltage in a power grid. The concept of non-cooperative, extensive = form games is used to model the interaction among power-system components that have the capacity to control reactive power flows in the system. A centralized method of control is formulated using an IEEE 6-bus test system, which is further translated to a method for distributed control using the New England 39-bus system. The determination of optimal generator settings leads to an improvement in load-voltage compliance. Finally, renewable-energy (reactive power) sources are integrated to further improve the voltage-compliance level.
Propagation of Neutron Waves in Moderating Media

Use of a sinusoidally modulated source of neutrons is equivalent to poisoning a moderating medium with a 1/v poison. The inverse relaxation length of the neutron wave amplitude and the variation of the phase angle as a function of position are dependent upon the frequency of modulation and the neutron diffusion and thermalization parameters of the media in which the waves are being propagated. The neutron wave technique allows poisoning of solid moderators and provides a means of performing poisoning experiments for measuring nuclear properties of solid as well as liquid moderators. It should supplement the recent use of poisoning techniques in an attempt to reconcile discrepancy in the diffusion and thermalization parameters of moderators, as measured by pulsed neutron techniques. The neutron wave technique and the pulsed neutron teclmique are supplementary from an experimental viewpoint. (auth)
Rearview Camera-Based Stixel Generation for Backing Crash Prevention

Backing crashes have become a serious problem, resulting in the United States announcing a rule requiring all vehicles to come equipped with rearview cameras. As a result of this situation, this paper proposes a method that detects obstacles behind a vehicle using a rearview camera with a fisheye lens. The proposed method represents obstacles by means of the Stixel World, and it consists of two stages: free space boundary detection and obstacle height estimation. In the first stage, obstacles are three-dimensionally reconstructed, and the 3D points are spatially interpolated and sequentially accumulated. An occupancy grid map is generated with depth and incidence angle axes to effectively handle a wide field-of-view situation. In the second stage, this method combines some complementary information to reliably estimate the obstacle height using spare 3D points. Three cost maps based on 3D points, color similarity, and edge strength are calculated and fused in height and incidence angle axes. The free space boundary and the obstacle height are estimated by finding the optimal paths in the occupancy grid map and the fused cost map, respectively. Finally, Stixels are generated by integrating the free space boundary and obstacle height. In the experiment, the proposed method was quantitatively evaluated and compared with the previous methods in various road, obstacle, and background conditions.
The analysis of the broad hydrogen Balmer line ratios: Possible implications for the physical properties of the broad line region of AGNs

Aims. We analyze the ratios of the broad hydrogen Balmer emission lines (from H α to H ε ) in the context of estimating the physical conditions in the broad line region (BLR) of active galactic nuclei (AGNs). Methods. Our measurements of the ratios of the Balmer emission lines are obtained in three ways: i) using photoionization models obtained with a spectral synthesis code CLOUDY; ii) applying the recombination theory for hydrogenic ions; iii) measuring the lines in observed spectra taken from the Sloan Digital Sky Survey database. We investigate the Balmer line ratios in the framework of the so-called Boltzmann plot (BP), analyzing the physical conditions of the emitting plasma for which we could use the BP method. The BP considers the ratio of Balmer lines normalized to the atomic data of the corresponding line transition, and in that way di ﬀ ers from the Balmer decrement. Results. We ﬁnd that for a certain range of thermodynamic parameters, there are objects that follow the BP. These AGNs may have a BLR consisting of mostly high density plasma.
Spatio-temporal synchronization of heavy rainfall events triggered by atmospheric rivers in North America

Atmospheric rivers (ARs) are filaments of extensive water vapor transport in the lower troposphere, that play a crucial role in the distribution of water, but can also cause natural and economical damage by facilitating heavy rainfall. Here, we investigate the large-scale spatio-temporal synchronization patterns of heavy rainfall over the western coast and the continental regions of North America (NA), during the period from 1979 to 2018. In particular, we utilize event synchronization and a complex network approach incorporating varying delays to examine the temporal evolution of spatial patterns of heavy 5 rainfall events in the aftermath of land-falling ARs. For that, we employ the SIO-R1 catalog of ARs that land-fall over the western coast of NA, categorized in terms of strength and persistence on an AR-intensity scale which varies from category 1 to 5 , along with daily rainfall estimates from the ERA5 reanalysis with 0 . 25 ◦ spatial resolution. Our analysis reveals a cascade of synchronized heavy rainfall events, triggered by ARs of category 3 or higher: in the first 3 days after the first day of an AR strike, rainfall events mostly occur and synchronize along the western coast of NA. In the subsequent days, moisture can 10 be transported to central and eastern Canada and cause synchronized but delayed heavy rainfall there. Furthermore, we assess the robustness of our findings by studying an additional AR detection method. Finally, analyzing the anomalies of integrated water vapor transport, geopotential height, upper-level meridional wind, and rainfall, we find atmospheric circulation patterns that the corresponding climatologies of different variables such as upper-level meridional wind and geopotential height at 500 hPa.
Finding Pulsar Emission Heights from Dual–Frequency Observations

We present a method that allows to find the radial separation of regions emitting individual components of pulsar average profiles at two radio frequencies. It may also be used for single–frequency observations in pulsars that have intensity–dependent average profiles and/or mode–switching. Preliminary results for three radio pulsars are presented, obtained using average profiles from non-simultaneous observations.
The Association of Selective Serotonin Reuptake Inhibitors With Delirium in Critically Ill Adults: A Secondary Analysis of the Bringing to Light the Risk Factors and Incidence of Neuropsychologic Dysfunction in ICU Survivors ICU Study

OBJECTIVES: To assess the association between selective serotonin reuptake inhibitors (SSRI) and delirium in the subsequent 24 hours after drug administration in critically ill adults. DESIGN: Retrospective cohort study utilizing the Bringing to Light the Risk Factors and Incidence of Neuropsychologic Dysfunction in ICU Survivors dataset. SETTING: Two large U.S. ICUs. PATIENTS: Critically ill adults admitted to a medical or surgery ICU between March 2007 and May 2010 with respiratory failure or shock. INTERVENTIONS: Our primary outcome was the occurrence rate of delirium or coma during each day in the ICU. Our exposure variable was SSRI administration on the prior day in the ICU. As a secondary question, we assessed the association of SSRI administration and delirium the same day of SSRI administration in the ICU. MEASUREMENTS AND MAIN RESULTS: We analyzed 821 patients. The median age was 61.2 years old (interquartile range, 50.9–70.7), and 401 (48.8%) were female. A total of 233 patients (28.4%) received prescribed SSRIs at least once during their ICU admission. Delirium was present in 606 (74%) of the patients at some point during hospitalization in the ICU. Coma was present in 532 (64.8%) of the patients at some point during hospitalization in the ICU. After adjusting for multiple potential confounding factors, we found that SSRI administration in the ICU was associated with lower odds of delirium/coma (odds ratio [OR], 0.75; 95% CI, 0.57–1.00) the next day. An SSRI administered on the same day reduced the odds of delirium/coma as well (OR, 0.66; 95% CI, 0.50–0.87). CONCLUSIONS: SSRI administration is associated with decreased risk of delirium/coma in 24 hours and on the same day of administration in critically ill patients in a medical or surgical ICU.
Opioid Prescribing Patterns Before, During, and After Critical Illness: An Observational Study

OBJECTIVES: The association between opioid therapy during critical illness and persistent opioid use after discharge is understudied relative to ICU opioid exposure and modifiable risk factors. Our objectives were to compare persistent opioid use after discharge among patients with and without chronic opioid use prior to admission (OPTA) and identify risk factors associated with persistent use. DESIGN: Retrospective cohort study. SETTING: Medical, trauma/surgical, or neurologic ICU at an academic hospital. PARTICIPANTS: Adult patients surviving hospital admission. INTERVENTIONS: Opioid use during the ICU and post-ICU stays. MEASUREMENTS AND MAIN RESULTS: The primary outcome was persistent opioid use accounting for greater than 70% of days 4–6 months after discharge. Among 2,975 included patients, 257 (8.6%) were classified as OPTA, and 305 (10.2%) persistently filled opioid prescriptions, including 186/257 (72%) OPTA and 119/2,718 (4.4%) with no chronic opioid fills prior to admission. Among all patients, OPTA was strongly associated with persistent opioid use (odds ratio, 57.2 [95% CI, 41.4–80.0]). Multivariable logistic regression revealed that male sex, surgical procedure, and ICU opioid-free days were associated with reduced persistent opioid use for OPTA patients. Age and ICU opioid-free days were associated with reduced persistent opioid use for non-OPTA patients. Total ICU opioid dose and dose per day of ICU exposure were not associated with persistent use for either group. CONCLUSIONS: In this mixed cohort of ICU patients, 10.2% persistently filled opioid prescriptions 4–6 months after discharge. Although ICU opioid doses were not associated with persistent use, duration of ICU opioid administration is a modifiable risk factor that may reduce persistent opioid use after critical illness.
Advance prediction of coastal groundwater levels with temporal 1 convolutional network 2

Xiaoying Zhanga,b, Fan Donga,b, Guangquan Chenc, Zhenxue Daia,b* 3 a Institute of Intelligent Simulation and Early Warning for Subsurface Environment, 4 Jilin University, Changchun, China 5 bCollege of Construction Engineering, Jilin University, Changchun , China 6 cKey Laboratory of Marine Sedimentology and Environmental Geology, First 7 Institute of Oceanography, State Oceanic Administration, Qingdao, China 8 * Correspondence: Zhenxue Dai, dzx@jlu.edu. cn 9 10 Highlights 11
Monitoring design pattern for distributed automation systems in IEC 61499 and its formal modelling

This paper addresses the challenge of achieving reliable and predictable operation of flexible and modular pro-duction systems with distributed control and potentially wireless communication. Such systems are envisaged as common in the future Industry 4.0 production facilities. A software design pattern is proposed to implement online monitoring of requirements. The IEC 61499 architecture is selected as the implementation platform and its benefits are essentially used by utilisation of the adapter interface mechanism. The paper also outlines a pathway to designing and verifying the monitors based on formal methods.
The effect of coronavirus disease-2019 (COVID-19) according to gender on health-related quality of life

Aim: The purpose of this study was to evaluate the changes in health-related quality of life of hospitalized patients with the diagnosis of coronavirus disease-2019 (COVID-19) according to gender. Material and Method: The medical records of 77 patients (37 females and 40 males) who were hospitalized for COVID-19 were examined. Sociodemographic features including age, gender, marital status, comorbid diseases, duration of hospitalization, the period after discharge, symptoms of COVID-19 disease were analyzed. Short Form 36 (SF-36) was applied to all patients for evaluating the health-related quality of life pre and post COVID-19. Results: The median scores of physical function, bodily pain, vitality, social functioning and general health perceptions before COVID-19 were statistically significantly higher than the scores after COVID-19 in both gender. Social functioning and the scores were lower in females than males for pre and post COVID-19 period and the differences were statistically significant. Conclusions: The findings of this study revealed that health-related quality of life is affected by COVID-19 for both genders, mostly females.
The missing base molecules in atmospheric acid–base nucleation

Abstract Transformation of low-volatility gaseous precursors to new particles affects aerosol number concentration, cloud formation and hence the climate. The clustering of acid and base molecules is a major mechanism driving fast nucleation and initial growth of new particles in the atmosphere. However, the acid–base cluster composition, measured using state-of-the-art mass spectrometers, cannot explain the measured high formation rate of new particles. Here we present strong evidence for the existence of base molecules such as amines in the smallest atmospheric sulfuric acid clusters prior to their detection by mass spectrometers. We demonstrate that forming (H2SO4)1(amine)1 is the rate-limiting step in atmospheric H2SO4-amine nucleation and the uptake of (H2SO4)1(amine)1 is a major pathway for the initial growth of H2SO4 clusters. The proposed mechanism is very consistent with measured new particle formation in urban Beijing, in which dimethylamine is the key base for H2SO4 nucleation while other bases such as ammonia may contribute to the growth of larger clusters. Our findings further underline the fact that strong amines, even at low concentrations and when undetected in the smallest clusters, can be crucial to particle formation in the planetary boundary layer.
GoldenEye: A Platform for Evaluating Emerging Numerical Data Formats in DNN Accelerators

This paper presents GoldenEye, a functional simulator with fault injection capabilities for common and emerging numerical formats, implemented for the PyTorch deep learning framework. GoldenEye provides a unified framework for numerical format evaluation of DNNs, including traditional number systems such as fixed and floating point, as well as recent DNN-inspired formats such as block floating point and AdaptivFloat. Additionally, GoldenEye enables single- and multi- bit flips at various logical and functional points during a value’s lifetime for resiliency analysis, including for the first time attention to numerical values’ hardware metadata. This paper describes Golden-Eye’s technical design and implementation which make it an easy-to-use, extensible, versatile, and fast tool for dependability research and future DNN accelerator design. We showcase its utility with three case studies: a unifying platform for number system comparison and evaluation, a design-space exploration heuristic for data type selection, and fast DNN reliability analysis for different error models. GoldenEye is open-sourced and available at: https://github.com/ma3mool/goldeneye.
Online User and Power Allocation in Dynamic NOMA-Based Mobile Edge Computing

This study tackles the online user allocation problem in mobile edge computing (MEC) systems powered by non-orthogonal multiple access. App vendors need to determine a proper wireless channel in a base station/edge server and sufficient transmit power for every user. We consider a stochastic MEC system where users arrive and depart over time. When an edge server runs out of computing resources, some users will have to wait until the resources become available again, which incurs an allocation delay cost. This cost is often not investigated in many studies, which also do not consider a multi-cell, multi-channel system as we do in this work, due to its complexity. We aim to minimize the allocation delay and transmit power costs, increasing the system's energy efficiency. To achieve this objective while guaranteeing users’ data rate requirements over time, we adopt the Lyapunov framework to convert this long-term optimization problem into a series of subproblems to be solved in every time slot. To solve the aforementioned subproblems efficiently, we present a distributed game theory-based approach. The proposed algorithm is theoretically evaluated and experimentally demonstrated to outperform several baseline and state-of-the-art methods, highlighting the significance of systematic consideration for both computation and communication aspects of this problem.
Characterization of the complete plastome of Thalictrum aquilegiifolium var. sibiricum (Ranunculaceae), an annual herb

Abstract Thalictrum aquilegiifolium var. sibiricum, is an annual herb that grows on slopes or in mountain gullies in areas of damp forest. In this study, we report for the first time the complete plastome sequence of T. aquilegiifolium var. sibiricum. The plastome sequence is 156,244 bp in length and comprises a large single-copy region (85,447 bp), a small single-copy region (17,599 bp), and a pair of inverted repeat regions (26,480 bp). The genome encodes 112 unique genes, including 78 protein-coding genes, 30 tRNAs, and four rRNAs, and has total GC content of 38.4%. Phylogenomic analysis based on the plastome sequences of 20 species in the family Ranunculaceae indicated that T. aquilegiifolium var. sibiricum is clustered with Thalictrum minus.