Miracle-dz/UniFAR-FTUs huggingface dataset:
Single-cell RNA-seq analyses show that long non-coding RNAs are conspicuously expressed in Schistosoma mansoni gamete and tegument progenitor cell populations

Schistosoma mansoni is a flatworm that causes schistosomiasis, a neglected tropical disease that affects over 200 million people worldwide. New therapeutic targets are needed with only one drug available for treatment and no vaccine. Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides with low or no protein-coding potential. In other organisms, they have been shown as involved with reproduction, stem cell maintenance and drug resistance, and they tend to exhibit tissue-specific expression patterns. S. mansoni expresses thousands of lncRNA genes; however, the cell type expression patterns of lncRNAs in the parasite remain uncharacterized. Here, we have re-analyzed publicly available single-cell RNA-sequencing (scRNA-seq) data obtained from adult S. mansoni to identify the lncRNAs signature of adult schistosome cell types. A total of 8023 lncRNAs (79% of all lncRNAs) were detected. Analyses of the lncRNAs expression profiles in the cells using statistically stringent criteria were performed to identify 74 lncRNA gene markers of cell clusters. Male gamete and tegument progenitor lineages clusters contained most of the cluster-specific lncRNA markers. We also identified lncRNA markers of specific neural clusters. Whole-mount in situ hybridization (WISH) and double fluorescence in situ hybridization were used to validate the cluster-specific expression of 13 out of 16 selected lncRNA genes (81%) in the male and female adult parasite tissues; for one of these 16 gene loci, probes for two different lncRNA isoforms were used, which showed differential isoform expression in testis and ovary. An atlas of the expression profiles across the cell clusters of all lncRNAs detected in our analysis is available as a public website resource (http://verjolab.usp.br:8081). The results presented here give strong support to a tissue-specific expression and to a regulated expression program of lncRNAs in S. mansoni. This will be the basis for further exploration of lncRNA genes as potential therapeutic targets.
Cosmological constant from quantum spacetime

We show that a hypothesis that spacetime is quantum with coordinate algebra $[x^i,t]=\lambda_P x^i$, and spherical symmetry under rotations of the $x^i$, essentially requires in the classical limit that the spacetime metric is the Bertotti-Robinson metric, i.e. a solution of Einstein's equations with cosmological constant and a non-null electromagnetic field. Our arguments do not give the value of the cosmological constant or the Maxwell field strength but they cannot both be zero. We also describe the quantum geometry and the full moduli space of metrics that can emerge as classical limits from this algebra.
Pankuangia haifanggouensis gen. et sp. nov., a Fossil Plant with Unknown Affinity from the Middle Jurassic Haifanggou Formation, Western Liaoning, Northeast China

Scale-likeleaves and occasional club-shaped appendages collected from the Middle Jurassic Haifanggou Formation, western Liaoning, Northeast China were de scribed. They were formerly considered by K. Pan to be dicots. But in this study we could not find the fact that they could be regarded as dicots. We are of the opinion that they would correspond to the scale leaves of a certain cycadophyte, but it is difficult to ascertain whether they are bennettitalean (e.g. Cycadolepis) or cycadalean (e.g. Deltolepis), because of the lack of their preserved cuticles. Under the circumstances, we propose a non-committal genus Pankuangia and describe P. haifanggouensis sp. nov. to accommodate the present specimens.
Role of Clinical and Parasitological data in Diagnosis of Chronic Urinary Schistosomiasis in comparison with other techniques

The gold standard for diagnosis of schistosomiasis haematobium is a microscopic examination of urine for parasite eggs. However, direct detection of eggs is difficult among people who have chronic infections.The aim of the current study was to detect the role of clinical and parasitological examination in the diagnosis of S.haematobium in comparison with PCR in chronic patients. Materials and methods: This study was conducted on 115 urine samples; 60 samples were collected from patients with cancer bladder, 35 samples from cases of urinary schistosomiasis, and 20 samples from a healthy control. Samples enrolled in the study were subjected to patient socio-demographic history, clinical data, and the collection of histopathological reports (in the case of cancer bladder patients). All urine samples were subjected to parasitological examination for the detection of S. haematobium eggs. Multiplex PCR was used for the detection of DNA fragments of S. haematobium in urine. Results: By multiplex PCR, it was revealed that 5 cases (8.3%) were positive for S. haematobium , while 55 cases (91.7%) were negative. PCR-positive cases were in the age of 44- 67 years. Diagnosis of S. haematobium infection in symptomatic (dysuria &haematuria) suspected bilharziasis patients by using the traditional parasitological examination for detection of eggs in urine revealed absolute diagnostic efficacy (100%). S. haematobium eggs were detected in the examined patients of age group from 15 to over 40 years. Conclusion: Using clinical and direct parasitological methods in association with history taking could be enough for the diagnosis of S. haematobium, especially in aged patients.
Psychometric Properties of the Turkish Version of Instagram Addiction Scale

The present study aimed to adapt the Instagram Addiction Scale (IAS), developed by D’Souza and colleagues (2018), into Turkish and investigate its psychometric properties in a Turkish sample. For this purpose, three studies were carried out. In Study 1, language validity of the scale was examined with 90 participants. In Study 2, the factor structure was explored, and reliability and validity analyses were conducted in a study sample of 451 university students. In Study 3, the scale’s confirmatory factor analysis was investigated with 468 Instagram users from the general population. Results showed that there was a strong positive correlation between the original English form and Turkish form in two groups. The Turkish form of the scale has a five-factor structure. The psychometric properties were adequate and test-retest reliability was found as . 77. Finally, in Study 3, results showed that the five-factor structure of the scale also worked for the general population. Data obtained from the three studies revealed that psychometric properties of the IAS were acceptable for the Turkish population.
Visualizing surfaces in Euclidean 3-space with VisuMath

As is well-known, surfaces in a 3-dimensional Euclidean Space can be represented locally by means of several types of equations. Although these are mathematically equivalent, this choice of representation can make a difference when it comes to visualizing the surface. More precisely, some representations may produce artifacts in the visualization that are merely a consequence of the visualization process itself. Sometimes, by rewriting equations or by switching to another representation, these can be avoided. In this paper, this phenomenon is explained and demonstrated by means of the new version of the visualization software VisuMath. Moreover, the new capabilities of the software and the geometry behind it, are explained. These include the possibility of dynamically changing the shape of surfaces by altering parameters in the representation. This feature can be useful in examining the precise role of parameters in the equation(s) representing the surface.
Benchmarking GPT-3 For Closed-Book QA: Strengths and Weaknesses

Large-scale pretrained language models (PLMs) have achieved rapid progress in recent years, dominating the leaderboards of various NLP tasks. In this work, we focus on one such model, namely GPT-3 (Brown et al., 2020). We thoroughly evaluate GPT-3 on the task of closed-book question answering (CBQA). Question answering is a knowledge-intensive task requiring signiﬁcant amount of factual knowledge. By constraining in the closed-book setting, models cannot retrieve knowledge from external knowledge bases but instead have to rely on the knowledge stored in their own parameters. By analyzing the performance of GPT-3 on different types of questions, we not only probe how much factual knowledge is stored in GPT-3, but also gain a better understanding of the strengths and weaknesses of GPT-3 in terms of different reasoning capabilities. To facilitate future work, we open source all the code, model predictions and human annotations in https://github.com/NoviScl/GPT3QA .
Exploring substance use perceptions among Family Therapy and Counseling trainees upon entering an opioid use disorder treatment training program

ABSTRACT Little is known about Couple/Marriage and Family Therapy (C/MFT) or Clinical Mental Health Counseling (CMHC) trainees with respect to their baseline perceptions about substance use and other systemically relevant therapeutic concepts integral to substance use disorder (SUD) treatment. Understanding trainee’s baseline perceptions upon entering a SUD-focused training program may allow for directed tailoring of the training to meet student’s educational needs in learning about how to work with families affected by SUD most effectively. To help address this gap, this study examined substance use perceptions of C/MFT and CMHC trainees upon initial enrollment in an opioid training program. Masters-level trainees completed a baseline survey assessing substance use/user perceptions, efficacy in working with substance-using clients, interprofessional collaboration, multicultural competency, and professional quality of life. Baseline data from n = 61 trainees were examined. Findings indicated substance use perceptions were related to trainee efficacy, multicultural competence, and professional quality of life. Further, there were group differences in drug perceptions based on previous substance use training and in trainee efficacy related to working with families affected by substance use, as well as and previous experience working with families affected by substance use. The current findings can inform development and refinement of substance use training within the behavioral health fields and develop the substance use workforce.
Transcutaneous electrical nerve stimulation reduces acute pain, and the use of analgesics after ankle fracture surgery

Objective: To evaluate the applicability of transcutaneous electrical nerve stimulation (TENS) as a complementary treatment method to non-opioid analgesics for acute postoperative pain in patients undergoing surgical treatment due to ankle fractures. Methods: A prospective, randomized, analytical, cross-sectional study performed after ankle fracture surgery. Two groups were randomized as follows: group 1 (Intervention) received TENS and non-opioid analgesic (dipyrone), and group 2 (Control) received non-opioid analgesic (dipyrone). Results: This study demonstrated that TENS in patients undergoing surgical treatment of ankle fractures reduces the use of rescue opioids significantly to control postoperative pain. Conclusion: TENS devices may be another safe option to control postoperative pain and reduce the use of opioids, avoiding adverse effects from this class of analgesic. Level of Evidence II; Therapeutic Studies; Prospective Comparative Study.
GALAXY FORMATION AT z > 3 REVEALED BY NARROWBAND-SELECTED [O III] EMISSION LINE GALAXIES

We present the physical properties of [O iii] emission line galaxies at z > 3 ? > as the tracers of active galaxies at 1 Gyr before the peak epoch at z ∼ 2 ? > . We have performed deep narrowband imaging surveys in the Subaru/XMM-Newton Deep Survey Field with the Multi-object InfraRed Camera and Spectrograph on the Subaru Telescope and have constructed coherent samples of 34 [O iii] emitters at z = 3.2 and 3.6, as well as 107 Hα emitters at z = 2.2 and 2.5. We investigate their basic physical quantities, such as stellar masses, star formation rates (SFRs), and sizes, using the publicly available multiwavelength data and high-resolution images from the Hubble Space Telescope. The stellar masses and SFRs show a clear correlation known as the “main sequence” of star-forming galaxies. It is found that the location of the main sequence of the [O iii] emitters at z = 3.2 and 3.6 is almost identical to that of the Hα emitters at z = 2.2 and 2.5. Also, we investigate their mass–size relation and find that the relation does not change between the two epochs. When we assume that the star-forming galaxies at z = 3.2 grow simply along the same main sequence down to z = 2.2, galaxies with M * = 10 9 ? > – 10 11 M ⊙ ? > increase their stellar masses significantly by a factor of 10–2. They climb up the main sequence, and their SFRs also increase a lot as their stellar masses grow. This indicates that star formation activities of galaxies are accelerated from z > 3 ? > toward the peak epoch of galaxy formation at z ∼ 2 ? > .
Electromagnetic Scattering From Rough, Finitely Conducting Surfaces

The problem of electromagnetic scattering from a statistically rough surface bounding a uniform, finitely conducting medium of infinite extent is treated in the Kirchhoff approximation. Both intensity and polarization of the scattered wave is considered. Explicit formulas are obtained for the special case of a normally distributed surface. Comparison is made with previous results obtained by other authors under the assumption of infinite conductivity.
A Note on Symplectic, Multisymplectic Scheme in Finite Element Method

We find that with uniform mesh, the numerical schemes derived from finite element method can keep a preserved symplectic structure in one-dimensional case and a preserved multisymplectic structure in two-dimensional case respectively. These results are in fact the intrinsic reason why the numerical experiments show that such finite element algorithms are accurate in practice.
The blockwise bootstrap for general parameters of a strationary time series

We study the blockwise bootstrap of Kunsch (1989) for a statistic which estimates a parameter of the entire distribution of a stationary time series. Because such a statistic is not symmetric in the observations, one should not simply resample blocks of the original data. When the parameter is the spectral distribution function or an ARMA parameter, the statistic is a symmetric function of all shifts of the sample extended suitably. Then we can resample blocks of shift indices, and the theory is basically the same as for a symmetric statistic. In other cases the statistic is a symmetric function of m-tuples of consecutive data where m increases with sample size. Then one can resample blocks of these m-tuples. But the increasing m makes the theory more delicate. We show validity of the bootstrap in two generic examples of spectral estimators, thereby extending results of Politis & Romano (1992).
The Quality of Tour Guides on Tourists’ Satisfaction in Malaysia Tourism Industry

Tour guides are one of the key players in the tourism industry as intermediaries between travel agents and tourists. They have a responsibility to explain the culture and all information involving the destination. This research aims to study the service quality of tour guides on tourist satisfaction. Empirical data were gathered from a large-scale online survey with 58 national and international tourists from Malaysia and Indonesia. The result shows that tour guides’ service quality has a positive relationship with tourist satisfaction
Exacerbation of Pre-existing Neurological Symptoms With COVID-19 in Patients With Chronic Neurological Diseases: An Updated Systematic Review

The neurotropism of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can potentially explain the worsening of symptoms in patients with a history of neurological conditions such as stroke, Parkinson's disease, Alzheimer's, and epilepsy. Several studies have reported that these pre-existing conditions may worsen with a higher frequency of flare-ups, thus resulting in a more significant risk of patient mortality. In this review, we sought to provide an overview of the relationship between pre-existing neurological disorders and COVID-19, focusing on whether the initial infection directly influenced the severity of symptoms. We systematically searched the electronic database PubMed (MEDLINE) and used specific keywords related to our aims from January 2020 to July 2022. All articles published on COVID-19 with keywords pertaining to pre-existing neurological diseases were retrieved and subsequently analyzed. After independent review, the data from 107 articles were selected and evaluated. After analyzing the data from selected articles reviewing the effect of COVID-19 on neurological conditions, we have documented the relationship between said pre-existing neurological diseases, showing an increased risk of hospitalization, admission length, worsening of symptoms, and even mortality in COVID-19 patients.
Contrasting strategies to cope with storm‐induced erosion events: a flume study comparing a native vs. introduced bivalve

Storm‐induced erosion events may alter the diversity of tidal flat communities by selecting species that can better tolerate such disturbances. Introduced and invasive species are highly adaptable to a wide range of abiotic characteristics, and this adaptability may make them better able to withstand erosion events. With a novel flume method, we compared the ability of two bivalve species to resist storm‐induced erosion: Cerastoderma edule, a native species to the Scheldt estuary in the Netherlands, and Ruditapes philippinarum, an introduced species that is successful in the Netherlands and worldwide. We used three sediment erosion rates to simulate storms of increasing severity. At the 10.6 and 15.9 cm h−1 sediment erosion rates, all R. philippinarum were surfaced, whereas only half C. edule were surfaced. However, after being brought to the sediment surface, C. edule were more readily transported by currents and waves than R. philippinarum due to differences in their shell shape. We concluded that the two bivalve species had different strategies to avoid mortality by severe storm erosion: C. edule avoided being surfaced and R. philippinarum avoided being transported. In this case, it appears that extreme storms favor the specific adaptations of a native species over the broad adaptability of a non‐indigenous one. Indeed, C. edule may be more likely to survive moderately extreme storms than R. philippinarum, though the most extreme storms would be equally devastating to both species.
Non-compact groups of inner type and factorization

We investigate Birkhoff (or triangular) factorization and (what we propose to call) root subgroup factorization for elements of a noncompact simple Lie group $G_0$ of inner type. For compact groups root subgroup factorization is related to Bott-Samelson desingularization, and many striking applications have been discovered by Lu (\cite{Lu}). In this paper, in the inner noncompact case, we obtain parallel characterizations of the Birkhoff components of $G_0$ and an analogous construction of root subgroup coordinates for the Birkhoff components. As in the compact case, we show that the restriction of Haar measure to the top Birkhoff component is a product measure in root subgroup coordinates.
AOFAS and Karlsson-Peterson scales in evaluating patients treated with modified Broström-Gould and suture tape augmentation for ankle instability: a performance analysis

Objective: The objective of this study was to evaluate the performance of the American Orthopedic Foot and Ankle Society (AOFAS) and Karlsson-Peterson scales in patients with lateral ankle instability treated with modified Bröstrom-Gould (MBG) plasty and suture tape augmentation. Methods: This retrospective, bicentric, cohort study involved consecutive patients with lateral ankle instability treated with MBG plasty and suture tape augmentation. The Visual Analog Scale (VAS), AOFAS scale, and Karlsson-Peterson scale were used in pre-/postoperative assessments. Results: Fifty-five patients who underwent MBG plasty and suture tape augmentation were included. Mean preoperative and postoperative VAS scores were 7.1 ± 1.4 and 1.3 ± 1.6 (p<0.001), respectively. Mean AOFAS scores were 61.3 ± 21.1 and 95.4 ± 8.4, respectively (p<0.001). Mean Karlsson-Peterson scale scores were 46.8 ± v14.3 and 95.2 ± v7.9 (p<0.001), respectively. Conclusions: The Karlsson-Peterson scale showed a better performance than the AOFAS scale in the clinical and functional evaluation of patients with ankle instability treated with MBG plasty and suture tape augmentation. Level of Evidence III; Therapeutic Studies; Comparative Retrospective Study.
A method for rearing and assessing the health of the sugarcane pest Dermolepida albohirtum (Coleoptera: Scarabaeidae)

Rearing insects in controlled conditions is a prerequisite to supply high‐quality specimens for bioassays. However, while artificial diets and standardized rearing methods have been developed for many phytophagous insects, especially Lepidoptera, there are limited published diets for root‐feeding Coleoptera which are commonly fed either grass roots or pieces of vegetables as a simple alternative to artificial diets during bioassays. These feeding options, while convenient, can be considered suboptimal as they do not maximise the insects' development and health. Additionally, it is also important to develop standardised screening methods designed to test sublethal effects of control agents which may have repellent, antifeedant, antimetabolic and/or delayed mortality effects. The greyback canegrub (Dermolepida albohirtum, Waterhouse) is the most damaging native pest of Australian sugarcane, but no rearing method or artificial diet has ever been developed for this species. Our objectives were to improve bioassay methodology for D. albohirtum by describing and developing standard rearing and health assessment protocols. We describe a successful rearing method to raise healthy D. albohirtum larvae with a total of 48.8% of first instars successfully moulting to the second instar. We also tested a modified artificial diet which increased the weight, size and food uptake of larvae compared to traditional methods (i.e., pieces of carrots). For example, the average weight increase of larvae fed with the modified diet was 3.4 times higher than for carrot‐fed larvae while modified diet‐fed larvae were 2.1 times wider than if they were fed with carrots. Finally, we developed a method to measure larval activity which can be used to identify sublethal effects of control agents such as effects on activity level. Our methods may also be applied to improve bioassay methodology for other root‐feeding Coleoptera.
Nonlinear MHD Stability and Dynamical Accessibility

We obtain sufficient conditions for the stability of equilibria for two- and three-dimensional MHD, and generalizations of MHD, by using dynamical accessibility. The use of dynamical accessibility ensures that the physical perturbations preserve the natural constraints on the system imposed by the Hamiltonian structure. 1 Our procedure is a generalization of the work of Newcomb, 2 Frieman and Rotenberg, 3 and Arnold, 4 among others, who make use of