Miracle-dz/UniFAR-FTUs huggingface dataset:
Mitochondria: The Secret Chamber of Therapeutic Targets for Age-Associated Degenerative Diseases

－ Mitochondria have long been recognized as ATP engines for the cell and recently as a dynamic and mobile organelles that control cell death and life. This exquisite organelle is the site of reactive oxygen species production and is highly vulnerable to exogenous stresses, resulting in catastrophic damage to the cell. Mitochondrial dysfunction is linked to a wide range of age-associated degenerative diseases, such as metabolic syndrome, cardiovascular disease, and neurodegenerative diseases. Understanding the molecular mechanisms of mitochondria-dependent pathogenesis may provide important strategies to treat these diseases. Indeed, mitochondria are emerging therapeutic targets for the mitochondria-related diseases. In this paper, we review the recent concepts of mitochondrial biology and how mitochondria are involved in age-associated degenerative diseases. Furthermore, we summarize the therapeutics which target to improve mitochondrial functions.
Does Marketing Self-Efficacy stimulate New Firm formation?: Empirical Evidence from Korea

Marketing self-efficacy, linked to the skills and competencies of marketing field has not received enough attention on the prediction of new firm formation in past research despite marketing is a key entrepreneurial competency, particularly marketing and entrepreneurship are crucial when setting up a new firm. The purpose of this study then was to examine the relationship between marketing self-efficacy and new firm formation. Questionnaires was employed to collect data from two Korean graduate schools. A total of 250 completed questionnaires were returned. Regression analysis was used to test the hypothesis. Results showed that marketing self-efficacy had a positive effect on new firm formation. These results suggest theoretical and practical implications as an important factor to stimulate new firm formation.
Modeling “non-literal” social meaning 1

Truth-conditional and socially indexical meanings have traditionally been studied in separate subﬁelds. However, recent years have seen promising attempts to unify the semantics and pragmatics of the two (e.g. Smith et al., 2010; Acton and Potts, 2014). In particular, Burnett (2017, 2019) introduces a formalization of social meaning in terms of the Rational Speech Act (RSA) paradigm (Goodman and Frank, 2016). Building on this work, we address a central observation of contemporary sociolinguistics, that a linguistic variant may be used to index only some aspects of a speaker’s identity. For instance, an adult can use childlike language features to convey not that they are a child (ﬁrst order indexicality), but that they have certain traits associated with children, like cuteness or innocence (second order indexicality). Similarly, Eckert (2008) notes that some suburban Detroit teenagers use phonetic and syntactic forms conventionally associated with urban Detroit (such as vowel backing and negative concord), and hypothesizes that this is not to signal urbanity (i.e., I am from urban Detroit ) per se, but rather to afﬁliate with certain perceived aspects of urbanity, such as being “autonomous, tough, and street-smart”. We model such uses of indexes with the mechanism of projection functions (Kao et al., 2014), to allow for utterances which are informative only along particular dimensions of meaning.
An Ant Colony Optimization Algorithm for Cellular Manufacturing System

In this paper, an ant colony algorithm is used to solve the machine part cell formation problem based on the machine – index - based local procedure and part assignment rule for the better clustering of machines in to machine cells and parts in to part families. The main objective of this paper is to increase the grouping efficacy which is one of the good performance measures for the cell formation problem. The performance assessment of the ant colony algorithm was carried out by testing with the benchmark problems from the literature. From this assessment it clearly shows that this machine index based local procedure is capable to solve the machine part cell formation problem efficiently.
Dispersion optimization using a genetic algorithm

: The presented works concern the traceability phenomenon implementation within the production organisation, particularly in the field of raw materials management in the food industry. This project aims to minimise the raw material’s dispersion in the manufactured products. We seek to solve the problem of raw materials allocation into finished products, in order to minimise its dispersion and moreover, the products recall if needed. The dispersion criteria are afterwards used to determine production’s criticality in terms of sanitary risk, from which it is possible to optimise the processes of picking and dispatching. The final objective is to reduce the number of recalls in case of a crisis using the traceability information and the decision making tools. To solve the first part of the problem, a genetic algorithm is proposed.
N 2-fixing cyanobacteria and their potential applications

Cyanobacteria are N2-fixing oxygenic phototrophs with potential as sources of nitrogenous biofertilizer independent of fossil fuels. Recently, attention has been paid to their role in this respect, and to strain selection to facilitate enhanced agricultural productivity. The capacities to fix N2 in the presence of combined nitrogen, to resist herbicides and to tolerate salinity changes and desiccation are of particular importance. Mutant strains of N2-fixing cyanobacteria with potential applications have been produced, including strains which photoproduce ammonia and amino acids, strains with altered transport systems and strains which are herbicide-resistant. By using bioreactors and immobilization systems in conjunction with these strains, techniques have been developed for extracellular product-liberation. Gene transfer systems are now available in both unicellular and filamentous cyanobacteria and these offer the possibility of strain selection and modification. The way in which these advances will contribute to the development of strains with desirable attributes for use in the field is discussed. in bioreactors with photosynthetic N2-fixing cyanobacteria.
Comparative analysis of OFDM and GFDM

In recent past there are multiple, multicarrier techniques as an alternate of OFDM like Filter Bank Multi-Carrier (FBMC), Universal Filtered Multi-Carrier (UFMC) and Generalized Frequency Division Multiplexing (GFDM) as upcoming 5th Generation cellular systems. Performance of GFDM and OFDM needs to be investigated, since GFDM is increasing the performance of cellular communication system, so it needs to analyses the waveforms of both the techniques. In this work, we have checked the main characteristics of proposed wave forms and the relevant features. We conducted comparative analysis between GFDM and OFDM Bit error rate (BER) vs. Signal to Noise Ratio (SNR). GFDM is flexible in nature and its orthogonality gives it an edge over OFDM and which make it most suitable for the 5G technology.
Consensus in discrete-time multi-agent systems with uncertain topologies and random delays governed by a Markov chain

In this paper, we study consensus problem in a discrete-time multi-agent system with uncertain topologies and random delays governed by a Markov chain. The communication topology is assumed to be directed but interrupted by system uncertainties. Furthermore, the system delays are modeled by a Markov chain. We first use a reduced-order system featuring the error dynamics to transform the consensus problem of the original one into the stabilization of the error dynamic system. By using the linear matrix inequality method and the stability theory in stochastic systems with time-delay, several sufficient conditions are established for the mean square stability of the error dynamics which guarantees consensus. By redesigning its adjacency matrices, we develop a switching control scheme which is delay-dependent. Finally, simulation results are worked out to illustrate the theoretical results.
Knowledge, Attitude and Practice of Breast Selfexamination among Nursing Students in Hong Kong: A Cross-sectional Study

—Breast cancer is a global public health concern. Currently, the crude incidence rate of breast cancer in Hong Kong is increasing. Although breast self-examination (BSE) is an effective screening method which able to reduce mortality rates, only a few women perform it monthly. As nurses play a significant role in promoting BSE, this study aims to study the knowledge, attitude, and practice of BSE for nursing students. A cross-sectional design was employed, and 372 nursing students participated in this study. Results reveal that even BSE are compulsory in nursing curriculum, poor knowledge (“don’t know” 46.9%, incorrect 9.4%.), poor attitude (mean = 24.29, SD = 3.49) and limited practice (mean = 7.69, SD = 4.66) were found. Regression analysis support that knowledge and attitude predict practice of BSE. It is important to promote and build up the awareness of BSE to nursing students by enhancing their knowledge and attitude.
Removal of water-soluble arsenicals with phosphorene oxide nanoadsorbents: A first-principles study

: Novel layered materials for arsenic control have emerged as new alternatives to commercial adsorbents, featuring a large surface area, high adsorption capacity, and easy recovery. In this work, we present a picture of the phosphorene oxide (PhosO) sorption properties via first-principles calculations for the simultaneous adsorption of inorganic As(III) and As(V) contaminants from water. Adsorption energies, competitive adsorption with co-existing species, energy decomposition analyses (ALMO-EDA), implicitly/explicitly solvated structures, and adsorption free energies provide deep insights into the adsorption mechanism as well as the origin of the strong selectivity adsorption ability. The PhosO nanoadsorbents establish inner-sphere surface complexes with arsenicals even under water environments. These nanostructures also show a strong affinity with the highly mobile As(III), where energy saving is achieved by avoiding the pre-oxidation process to convert As(III) into As(V) as requested in related materials. Electrostatic driving forces govern the adsorption mechanism of neutral arsenicals, while the interplay between electrostatic and polarization phenomena drives the adsorption mechanism of anionic arsenicals. Moreover, the optimum adsorption efficiency is reached with a 25% in the content of oxidizing groups, where the strong repulsive surface charge at high pH turns the nanoadsorbents convenient to recycle via simple treatment with alkaline eluents. Finally, the adsorption ability remains thermodynamically allowed in a wide range of ambient temperatures (enthalpically governed reaction). Conceptually understanding the adsorption properties of phosphorene-oxide-based materials towards water-soluble arsenic pollutants provides a useful framework for new developments in future water treatment technologies. total stabilizing energy and
Evidence Based Care Journal Effect of Multi-Component Program on Promoting Safety of Hospitalized Children

Background: The role of family caregivers in the promotion of safety for hospitalized children is an important issue in the area of safety improvement. However, there are limited studies related to innovative programs. Aim: This study aimed to investigate the effects of a multi-component program on family caregiver’s knowledge and engagement in promoting safety. Method: A quasi-experimental study was performed on 160 female family caregivers in two pediatric wards of two public hospitals in Thailand, in 2019. Participants were assigned into two groups of intervention (n=80) and control (n=80) through consecutive sampling. The program was developed based on the standardized guidelines of child patient safety. Participants were educated and trained. The participants’ knowledge and engagement were measured using validated questionnaires. An analysis of covariance (ANCOVA), controlling for some possible confounders, was performed to examine the effect of intervention. Results: Family caregivers gained more knowledge after the implementation of the Multi-Component Program. They noticed if something was wrong and checked the administration of medication by nurses after the intervention. Engagement in promoting safety was enhanced in each domain. Mean±SD scores of three dimensions of Multi-Component Program including advocate to ask, report and response, and dimension monitoring were obtained at 4.61±0.26, 4.48±0.19, and 4.76±0.25, respectively. Moreover, the groups’ post-test scores of knowledge and engagement were significantly different (P<0.001) after adjusting the length of stay. Implications for Practice: The Leaflet, Poster, Talking, Video, and SMS program can enhance a family caregiver’s ability to take responsibility for children. The findings indicated the possible range of safety behaviors that family caregivers can perform during the childcare process. Healthcare providers should adopt this program as a part of child safety promotion in hospital settings.
Test Anxiety in First-Generation Students: An Examination of the Role of Psychological Needs

It is estimated that 15-22% of students have high levels of test anxiety (von der Embse, Jester, Roy, & Post, 2018), which can be associated with greater academic stress and poorer educational performance (e.g., Steinmayr, Crede, McElvany, & Withwein, 2016). First-generation students (where neither parent has completed post-secondary education) are a critical group to study given that they are at higher risk for poorer educational attainment and being unsuccessful at the post-secondary level. Therefore, the purpose of this study was to examine the link between basic psychological needs and test anxiety in a sample of first-generation Ontario high school students across two points in time ( N = 147; M age = 14.82, SD = 1.28). Self-report data was collected as a part of an on-going longitudinal study focusing on students attending a high school with specialized programming to enhance the transition to post-secondary institutions. Results from cross-lagged path analyses indicated that being older, female, and having higher levels of needs frustration significantly predicted higher levels of test anxiety over time within this sample. Our results highlight important educational implications, emphasizing the importance of fostering classroom environments where students perceive their psychological needs to be met, particularly within this unique population of students.
In Defence of Evaluative Compatibilism and Critical Evaluative Free Will Optimism A Consequentialist Assessment of the Free Will Debate

In this thesis, I will consider various aspects of the contemporary free will debate from a consequentialist perspective. In chapter 1, I will endorse a particular theory of what matters in life and a certain view of what moral rightness consists in. In chapter 2, I will provide an outline of all the various freedoms that have been proposed as (parts of) accounts of free will and of all the various responsibilities that have been proposed as (parts of) accounts of moral responsibility. In chapter 3, then, I will proceed to argue in favor of my first main thesis – that, of all the freedoms that have been proposed as (parts of) accounts of free will, all valuable freedoms are compatible with determinism, and that, of all the responsibilities that have been proposed as (parts of) accounts of moral responsibility, all valuable responsibilities are compatible with determinism (evaluative compatibilism). Finally, in chapter 4, I will argue in favor of my second main thesis – that, of all the freedoms that have been proposed as (parts of) accounts of free will, all valuable freedoms exist in the actual world and that, of all the responsibilities that have been proposed as (parts of) accounts of moral responsibility, all valuable responsibilities exist in our world, but that everyday and scientific observations do indicate that we have some valuable freedoms and responsibilities to a lesser degree than would be ideal (critical evaluative optimism). I do not expect to have convinced you, by the end of this thesis, that my ethical theories are the most intuitive ones; and neither do I expect to convince all of you that both (or either) of my main theses are (is) correct. What I do hope to convince you of, however, is that ethics is more important to the free will debate than many seem to think. For some ethical theories, the problem of free will simply does not have an edge. That is something we should all acknowledge.
Institutional Knowledge at Singapore Management Structural Change Estimation in Time Series Regressions with Endogenous Variables

• We propose to adopt the group fused lasso to estimate regression models with endogeneity and an unknown number of breaks. • We propose an information criterion to determine the number of breaks correctly with probability approaching one. • Post-Lasso GMM estimation be conducted as usual. • Simulations are done in comparison with some existing tests. • We apply our method to study the forward-looking monetary policy rule of the US from 1960 to 2012 and detect two breaks. We propose to apply the group fused Lasso to estimate time series models with endogenous regressors and an unknown number of breaks. It can correctly determine the number of breaks and estimate the break dates asymptotically. Simulations and applications are given. © 2014 Elsevier B.V. All rights reserved. 415-421. http://dx.doi. org/10.1016/j.econlet. 2014.10. 021 Abstract We propose to apply the group fused Lasso to estimate time series models with endogenous regressors and an unknown number of breaks. It can correctly determine the number of breaks and estimate the break dates asymptotically. Simulations and applications
Formulation Characterization, Invitro , Invivo and Pharmacokinetic Evaluation Of Stabilized Rosuvastatin Calcium Nanosuspension

Rosuvastatin calcium is a BCS class II drug which is used as hyperlipidemic. Many of the BCS class II drugs offer the disadvantage of solubility. Nanopar-ticle compounds present a promising solution to the insolubility of BCS class II drugs. A simple and ef(cid:977)icient technique for the preparation of nanoparticles is a precipitation technique. Polymeric nanoparticles have been prepared by employing the nanoprecipitation method. The nanosuspensions were made by using PVP K30, HPMC K15M, Eudragit L100 in various ratios using precipitation technique. DSC tests the compatibility between the drug and different ingredients. The formed nanoparticles were evaluated for multiple testing parameters like particle size, zeta potential, drug content and dissolution testing. Among all the formulations, the nanosuspension prepared with Eudragit L 100 showed better characteristics. The dissolution test showed the drug release for 12 hours. The best formulation showed the particle size of 100.5 (cid:6) 5.4 nm and zeta potential of -55.1 mv. The in vivo studies on the Wistar rats showed better pharmacokinetic parameters when compared to the pure drug. Nano precipitation method was successfully employed to prepare Rosuvastatin calcium nanosuspension to improve the dissolution as well as bioavailability.
TIF1 (cid:1) functions as a coactivator for C/EBP (cid:1) and is required for induced differentiation in the myelomonocytic cell line U937

Representational difference analysis (RDA) cloning has identified transcriptional intermediary factor 1 beta ( TIF1 (cid:1) ) as a gene inducibly expressed early during myeloid differentiation of the promyelocytic cell lines HL-60 and U937. To assess the role of TIF1 (cid:1) , U937 cell lines were made that expressed antisense-hammerhead ribozymes targeted specifically against TIF1 (cid:1) mRNA. These cells failed to differentiate into macrophages, as determined by several criteria: a nonadherent morphology, a failure to arrest cell cycle, lowered levels of macrophage-specific cell surface markers, resistance to Legionella pneumophila infection, a loss of the ability to phagocytose and chemotax, and decreased expression of chemokine mRNAs. One way TIF1 (cid:1) acts in macrophage differentiation is to augment C/EBP (cid:1) transcriptional activity. Furthermore, we show by EMSA supershifts and coimmunoprecipitation that C/EBP (cid:1) and TIF1 (cid:1) physically interact. Although TIF1 (cid:1) is necessary for macrophage differentiation of U937 cells, it is not sufficient, based on the inability of ectopically expressed TIF1 (cid:1) to induce or augment phorbol ester-induced macrophage differentiation. We conclude that TIF1 (cid:1) plays an important role in the terminal differentiation program of macrophages, which involves the coactivation of C/EBP (cid:1) and induction of C/EBP (cid:1) -responsive myeloid genes.
Destabilization of Messenger RNA/Complementary DNA Duplexes by the Elongating 80 S Ribosome*

In a previous study, we demonstrated that the ability of a cDNA fragment to hybrid-arrest the translation of its complementary mRNA in rabbit reticulocyte ly- sate depends on the position of the mRNA/cDNA duplex within the mRNA molecule. In the present report, we further characterize the mechanisms involved in the destabilization and subsequent translation of mRNA/ cDNA hybrids by mapping in detail the positional dependence of hybrid-arrested translation of the human a- and &globin mRNAs and by directly assessing the stability of mRNA/cDNA duplexes in reticulocyte lysate under a variety of translational conditions. The mapping studies in this report demonstrate that the translation of a hybridized mRNA requires exposure of the 5’ nontranslated region and the AUG initiation codon, as well as those bases 3’ to the AUG which are typically protected by an initiating 80 S ribosome. The translation of these mRNA/cDNA hybrids is associated with the complete removal of cDNA from the mRNA coding region; this disruption of the mRNA/cDNA duplex is blocked by inhibitors of translational initiation and elongation. cDNAs which extend into the 3’ nontranslated region remain associated with the mRNA during normal translation but are completely removed from the mRNA during translation if translational termination is suppressed. Taken together, these findings demonstrate that the disruption of mRNA/cDNA duplexes in rabbit reticulocyte lysate is tightly linked to the assembly and migration of 80 S ribosomes. ribosomes may the capacity to
Design and Optimization of a Wideband Metamaterial Absorber Made of Composite Materials

Using structural composite materials for the fabrication of Radar Absorbing Materials (RAM) allows combining the strong load bearing capability with the radar absorbing functionality in a unique structure. This article shows the possibility to transpose an already existing metamaterial absorber to the domain of composite materials. The dielectric layers of the absorber initially designed with radio-frequency (RF) materials are replaced with fiber-reinforced composite materials and their thickness is optimized again. The working principle of the absorber is explained layer by layer on the Smith chart. The performances of the composite absorber are compared against the initial RF design and against other classical absorbers. The composite design has a total thickness of 8.9 mm and achieves a reflection coefficient below -14 dB within the band 4.6 GHz - 17.2 GHz at normal incidence. The reflection coefficient remains under -10 dB at oblique incidence up to 45°.