Miracle-dz/UniFAR-FTUs huggingface dataset:
Incidence of Olfactory Dysfunction and Associated Factors: A Nationwide Cohort Study From South Korea

Objectives: Olfactory dysfunction, a reduced or complete loss of the ability to smell, is gaining attention because of its substantial impact on an individual’s quality of life and the possibility that it is an important sign of underlying disease. However, olfactory dysfunction is underdiagnosed in the general population due to diagnostic difficulty and unpredictable prognosis. This study aimed to evaluate the prevalence of clinically diagnosed olfactory dysfunction in South Korea by using well-organized, nationwide, population-based cohort data, and the associations between olfactory dysfunction and risk of neurodegenerative disorders. Methods: We investigated the Korean National Health Insurance Service–National Sample Cohort for patients diagnosed with olfactory dysfunction according to the International Classification of Diseases. Annual and overall incidence and prevalence of olfactory dysfunction during 2003 to 2013 and patient characteristics were analyzed. Based on those identified patients who were later diagnosed with neurodegenerative disorder, hazard ratios (HRs) of sociodemographic factors and comorbidities associated with neurodegenerative disorder were evaluated using a Cox proportional hazard regression model. Results: In total, 6296 patients were clinically diagnosed with olfactory dysfunction during the study period (524.67 patients/year). The prevalence increased annually and was higher in female patients. The incidence of neurodegenerative disorders among patients with olfactory dysfunction was 4.2% within the study period. Multivariate cox regression analysis of the patients (n = 249) revealed that diabetes mellitus (HR = 1.976) and depression (HR = 2.758) were significant risk factors. Conclusions: Olfactory dysfunction is underdiagnosed in South Korea, but it is clinically important considering the possibility of presymptom of neurodegenerative disorders. In clinical practice, we should consider its association with neurodegenerative disorders and possibly other systemic conditions.
Patient characteristics in Behçet’s Syndrome and their associations with major organ involvement: a single-centre experience of 2118 cases

Objectives: To evaluate the demographic and clinical characteristics of patients with Behçet’s syndrome (BS), and to define their associations with the presence of major organ involvement (MOI). Method: Medical records of 2118 patients (964 males, 1154 females) were analysed retrospectively. MOI was defined as the presence of at least one of vascular, eye, nervous, or gastrointestinal system involvement. Univariable and multivariable binary and ordinal logistic regression analyses were applied to assess the factors that were potentially associated with MOI. Results: The mean ± sd age at diagnosis was 30.5 ± 9.4 years. Genital ulcer and joint involvement were more common in females (both p < 0.001), while MOI was more frequent in males (p < 0.001). Genital ulcer (p < 0.001) and vascular involvement (p = 0.006) were more common in patients with a younger age at diagnosis, while joint involvement was more common in older patients. A total of 1097 patients (51.8%) had at least one MOI, 322 (15.2%) at least two MOIs, and 48 (2.3%) at least three MOIs. Male gender, smoking history, and absence of genital ulcer were significantly associated with MOI in multivariable binary logistic regression. Multivariable ordinal regression analyses confirmed the association between MOI and male gender and smoking, but not the protective effect of genital ulcers. In both regression analyses, we found no significant effects of age, human leucocyte antigen-B51, skin involvement, or joint involvement on MOI. Conclusion: Male gender and positive smoking history have a significant influence on the presence of MOI in patients with BS.
Tissue characterization of the medical fungus Hericium coralloides by focus-variation microscopy

ABSTRACT In this study, the potential of focus-variation microscopic imaging was evaluated in a study of morphological patterns of the potential medicinal fungus Hericium coralloides (Basidiomycota). We created three-dimensional reconstructions and visualizations using the imaging technique on a fresh H. coralloides basidioma. The aim was to approximate the spore dispersal efficiency of this basidiomata type regarding the investment of tissue biomass and its reproductive output (production of basidiospores). Results were correlated with published data gained from magnetic resonance imaging and micro-computed tomography. It is demonstrated that focus-variation microscopic imaging results in a more distinct picture of the morphology of the edible and potentially medicinal H. coralloides basidiomata. However, a direct measurement of spore production was not possible. Spore production could only be estimated in combination with a mathematical model because the surface was not directly measurable due to the cellular heterogeneity. However, focus-variation microscopic imaging allows a better and faster estimation of spore production compared with the published methods. Furthermore, it was found that a scanning resolution of 5× is sufficient for determining the fungal surface precisely because at a higher resolution artifacts occur, resulting in adulteration of the image.
Distinct contribution of hyperbaric oxygen therapy to human neutrophil function and antibiotic efficacy against Staphylococcus aureus

Staphylococcus aureus (SA) causes superficial and severe endovascular infections. The present in vitro study investigates the anti‐SA mechanisms of hyperbaric oxygen therapy (HBOT) on direct bacterial killing, antibiotic potentiation, and polymorphonuclear leukocyte (PMN) enhancement. SA was exposed to isolated human PMNs, tobramycin, ciprofloxacin, or benzylpenicillin. HBOT was used as one 90‐min session. Bacterial survival was evaluated after 4 h by quantitative bacteriology. PMN functionality as reactive oxygen species (ROS) production was measured by means of dihydrorhodamine 123 analysis. We showed that HBOT exhibits significant direct anti‐SA effects. HBOT increased the anti‐SA effects of PMNs by 18% after PMA stimulation (p = 0.0004) and by 15% in response to SA (p = 0.36). HBOT showed an additive effect as growth reductions of 26% to sub‐MICs of tobramycin (p = 0.0057), 44% to sub‐MICs of ciprofloxacin (p = 0.0001), and 26% to sub‐MICs of penicillin (p = 0.038). The present in vitro study provides evidence that HBOT has differential mechanisms mediating its anti‐SA effects. Our observation supports the clinical possibility for adjunctive HBOT to augment the host immune response and optimize the efficacy of antibiotic treatments.
Graţianite, MnBi2S4, a new mineral from the Bǎiţa Bihor skarn, Romania

Abstract The new mineral graţianite, MnBi2S4, is described from the Bǎiţa Bihor skarn deposit, Bihor County, Romania. Graţianite occurs as thin lamellae, intimately intergrown with cosalite and bismuthinite, or as flower-shaped blebs within chalcopyrite, where it is associated with cosalite and tetradymite. Graţianite displays weak to modest bireflectance in air and oil, respectively, and strong anisotropy. The mean empirical composition based on 20 electron probe microanalyses is: (Mn0.541Fe0.319Pb0.070Cu0.040 Cd0.009 Ag0.001)S0.980(Bi1.975Sb0.018)S1.993(S4.008Se0.012Te0.007)S4.027, corresponding to the ideal formula MnBi2S4. Graţianite crystallizes in the monoclinic system (space group C2/m). Single-crystal X-ray studies of material extracted by the focused ion beam-scanning electron microscopy (FIB-SEM) technique, and carried out on the MX2 macromolecular beamline of the Australian Synchrotron determined the following cell dimensions: a = 12.6774(25) Å, b = 3.9140(8) Å, c = 14.7581(30) Å, b = 115.31(3)°, V = 662.0(2) Å3, and Z = 4. The six strongest X-ray reflections and their relative intensities are: 3.448 Å (100), 2.731 Å (77), 2.855 Å (64), 3.637 Å (55), 3.644 Å (54), and 3.062 Å (51). Graţianite is the monoclinic analog of berthierite (FeSb2S4), garavellite [Fe(Bi,Sb)2S4] and clerite [Mn(Sb,As)2S4] (Nickel-Strunz class 02.HA.20). It is isostructural with synthetic sulfides and selenides in the MnBi2S4-MnSb2S4 and MnBi2Se4-MnSb2Se4 series, and with grumiplucite (HgBi2S4) and kudriavite, [(Cd,Pb)Bi2S4], 3P members of the pavonite homologous series. The mineral is named for Graţian Cioflica (1927-2002), formerly Professor in Mineralogy and Ore Deposits at the University of Bucharest, Romania. The Băiţa Bihor skarn, like others within the same belt, is geochemically complex. The availability of Cu, Zn, and Pb, but also Ag, Bi, Mo, and B, as well as a wide range of minor elements, has created an environment allowing for crystallization of an unusually diverse range of discrete minerals. Graţianite is part of the peculiar associations of Bi-Pb-sulfosalts and Bi-chalcogenides that are genetically related to Au-enrichment. This study demonstrates the versatility of FIB-SEM techniques for in situ extraction of small volumes of well-characterized material, coupled with single-crystal X-ray analysis using synchrotron radiation, for the characterization of new minerals
X‐ray absorption spectroscopy and density functional analysis of the Fe3+ distribution profile on Al sites in a chrysoberyl crystal, BeAl2O4:Fe3+

Chrysoberyl is one of the most interesting minerals for laser applications, widely used for medical purposes, as it exhibits higher laser performance than other materials. Although its utilization has been vastly expanded, the location of transition metal impurities, especially the iron that is responsible for chrysoberyl's special optical properties, is not completely understood. The full understanding and control of these optical properties necessitates knowledge of the precise location of the transition metals inside the structure. Therefore, synchrotron X-ray absorption spectroscopy (XAS), a local structural probe sensitive to the different local geometries, was employed in this work to determine the site occupation of the Fe3+ cation in the chrysoberyl structure. An Fe K-edge X-ray absorption near-edge structure (XANES) simulation was performed in combination with density functional theory calculations of Fe3+ cations located at different locations in the chrysoberyl structure. The simulated spectra were then qualitatively compared with the measured XANES features. The comparison indicates that Fe3+ is substituted on the two different Al2+ octahedral sites with the proportion 60% on the inversion site and 40% on the reflection site. The accurate site distribution of Fe3+ obtained from this work provides useful information on the doping process for improving the efficiency of chrysoberyl as a solid-state laser material.
Determinants of patients’ safety culture practices in a tertiary hospital in Nigeria

Background There is growing concern towards ensuring that patients are safe. Despite this, factors influencing safety practices and outcomes in healthcare delivery systems in Nigeria have not been determined exhaustively. Objective To determine the factors affecting patient safety culture (PSC) practices in a tertiary hospital in Nigeria. Materials and methods This cross-sectional descriptive study of care providers in a tertiary hospital in Nigeria was conducted from June to November, 2016. A self-administered structured questionnaire survey (QS) was used to assess PSC via 12 composites. Data were analysed using Statistical Package for Social Sciences version 22 and associations tested with Chi-square at p ≤ 0.05. Results Response rate is 87%, with a validity rate of 88%. Supervisor/manager expectations and actions promoting safety has the highest positive response of 70.7%, while Non-punitive response to error has the least, 43.1%. The overall PSC grade level is 62.3%. The knowledge of PSC is 54.5%, 54% never reports safety events. Knowledge of PSOP, Knowledge of the availability of PSU, Report of errors and Regular patient safety committee meetings (PSCM) influences the scores on four, three, two and seven PSC composite units (p < 0.05 respectively). Conclusions This study finds an apparently fair overall PSC grade level. Knowledge of PSOP and availability of PSC unit, reports errors and regular PSCM positively influences PSC. There is need for composite targeted cum overall improvement on PSC in the setting.
Barriers to and facilitators of medication error reporting from the viewpoints of nurses and midwives working in gynecology wards of Tabriz hospitals

Medication error reporting (MER) is an effective way to prevent their repetition in the future. The present study aimed to determine the frequency and factors associated with the causes of MEs and to identify barriers to and facilitators of MER. This descriptive-analytical cross- sectional study was conducted with proportional random sampling on 220 midwives or nurses working in public and private hospitals in Tabriz, Iran. In this study, data were collected using Haddon’s matrix. Data were analyzed using descriptive and inferential statistics. The prevalence of MEs in this study was 36.2%. The most common causes of MEs related to weakness of nurses, wards, management and physicians were nursing staff shortage (30.5%), ward work density (51.8%), low ratio of nurses and midwives per patient (70.7%), and illegible prescriptions (76.4%), respectively. Major barriers to MER reported by nurses and midwives were blaming the individual rather than the system (67.7%). Facilitators of MER were anonymous MRE system and feeling safe about working environment. Staff also reported that if reporting is beneficial (preventing future errors, correcting practice, increasing accountability), the odds of reporting MER will increase (54.5%). Given the underlying cause of MEs from the participants' point of view (staff shortage, fear of reprisal and reprimand), it is suggested that the system and health managers adopt appropriate strategies to reduce these important factors (reducing work density and creating a friendly environment).
Mosquito fauna in Extremadura (western Spain): Updated catalog with new records, distribution maps, and medical relevance

ABSTRACT: An important element of vector control and surveillance of mosquito-borne diseases is updated information on vector species distribution. The aim of this study was to collect available information about mosquito species reported in Extremadura between 1920 and 2020 and create a catalog that would combine both published data and our recent field identifications. An exhaustive list is hereby presented, including species status and detailed distribution maps at a municipal level as well as their importance for public health. A total of 33 species, classified into five genera: Anopheles (five species), Aedes (14), Culex (nine), Culiseta (four), and Orthopodomyia (one) has been recorded, including 31 autochthonous, one invasive, Aedes (Stegomyia) albopictus, and one disappeared since 1953, Aedes (Stegomyia) aegypti. For the first time in Extremadura, we report the presence of important vectors such as Aedes (Aedimorphus) vexans vexans and Culex (Culex) perexiguus, and the new record of six species in the province of Badajoz, namely: Aedes (Dahliana) echinus, Aedes (Fredwardsius) vittatus, Aedes (Ochlerotatus) berlandi, Aedes (Ochlerotatus) pulcritarsis, Culex (Culex) mimeticus, and Culiseta (Culiseta) subochrea. Nineteen of these species are potential vectors of medical and veterinary relevance.
Landmark-based geometric morphometric analysis of wing size and wing shape among Aedes albopictus (Skuse, 1894) populations in Turkey

ABSTRACT: Aedes albopictus (Skuse, 1894) has a widespread distribution that includes both temperate and tropical climates. It is a potential vector of several important worldwide arboviruses, including chikungunya, zika, and dengue, and its geographical distribution expands rapidly. Despite its vectorial importance, the bioecological features of this species in newly established environments are still not very well known. Thus, this study investigated phenotypic variations among Ae. albopictus populations from different regions in Turkey. This is the first comparative morphological study of Ae. albopictus populations in Turkey. The procrustes distances phenogram derived from wing data indicates that the shape differences among some populations and the population from the Aegean coast differ from the Black Sea populations. Size differences were also detected between some populations.
Research on the improvement of single tree segmentation algorithm based on airborne LiDAR point cloud

Abstract The correct individual tree segmentation of the forest is necessary for extracting the additional information of trees, such as tree height, crown width, and other tree parameters. With the development of LiDAR technology, the research method of individual tree segmentation based on point cloud data has become a focus of the research community. In this work, the research area is located in an underground coal mine in Shenmu City, Shaanxi Province, China. Vegetation information with and without leaves in this coal mining area are obtained with airborne LiDAR to conduct the research. In this study, we propose hybrid clustering technique by combining DBSCAN and K-means for segmenting individual trees based on airborne LiDAR point cloud data. First, the point cloud data are processed for denoising and filtering. Then, the pre-processed data are projected to the XOY plane for DBSCAN clustering. The number and coordinates of clustering centers are obtained, which are used as an input for K-means clustering algorithm. Finally, the results of individual tree segmentation of the forest in the mining area are obtained. The simulation results and analysis show that the new method proposed in this paper outperforms other methods in forest segmentation in mining area. This provides effective technical support and data reference for the study of forest in mining areas.
Evidence for two distinct thalamocortical circuits in retrosplenial cortex

Retrosplenial cortex (RSC) lies at the interface between perceptual and memory networks in the brain and mediates between these, although it is not yet known how. It has two distinct subregions, granular (gRSC) and dysgranular (dRSC). The present study investigated how these subregions differ with respect to their electrophysiology and connections, as a step towards understanding their functions. gRSC is more closely connected to the hippocampal system, in which theta-band local field potential oscillations are prominent. We therefore compared theta-rhythmic single-unit activity between the two RSC subregions and found, mostly in gRSC, a subpopulation of non-directional cells with spiking activity strongly entrained by theta oscillations, suggesting a stronger coupling of gRSC to the hippocampal system. We then used retrograde tracers to examine whether differences in neural coding between RSC subregions might reflect differential inputs from the anterior thalamus, which is a prominent source of RSC afferents. We found that gRSC and dRSC differ in their afferents from two AV subfields: dorsomedial (AVDM) and ventrolateral (AVVL). AVVL targets both gRSC and dRSC, while AVDM provides a selective projection to gRSC. These combined results suggest the existence of two distinct but interacting RSC subcircuits: one connecting AVDM to gRSC that may comprise part of the cognitive hippocampal system, and the other connecting AVVL to both RSC regions that may link hippocampal and perceptual regions. We suggest that these subcircuits are distinct to allow for differential weighting during integration of converging sensory and cognitive computations: an integration that may take place in thalamus, RSC or both. Highlights • The two retrosplenial cortex subregions, gRSC and dRSC, differ in their temporal firing characteristics and relation to theta oscillations. • There are differential afferents from the anteroventral thalamic nucleus to gRSC and dRSC, with the dorsomedial subnucleus projecting selectively to gRSC. • The anteroventral thalamus-retrosplenial cortex circuitry thus comprises two functionally and anatomically distinct but connected circuits, differentially connected to the hippocampal system, that may support the integration of cognitive and perceptual information.
Analysis of the mechanosensor channel functionality of TACAN

Mechanosensitive ion channels mediate transmembrane ion currents activated by mechanical forces. A mechanosensitive ion channel called TACAN was recently reported. We began to study TACAN with the intent to understand how it senses mechanical forces and functions as an ion channel. Using cellular patch-recording methods we failed to identify mechanosensitive ion channel activity. Using membrane reconstitution methods we found that TACAN, at high protein concentrations, produces non-selective, heterogeneous conduction levels that are not mechanosensitive and are most consistent with disruptions of the lipid bilayer. We determined the structure of TACAN using single particle cryo-EM and observe that it forms a symmetrical dimeric transmembrane protein. Each protomer contains an intracellular-facing cleft with a coenzyme-A co-factor, confirmed by mass spectrometry. The TACAN protomers are related in 3-dimensional structure to a fatty acid elongase, ELOVL. Whilst its physiological function remains unclear, we anticipate that TACAN is not a mechanosensitive ion channel.
A secondary metabolite drives intraspecies antagonism in a gut symbiont that is inhibited by peptidoglycan acetylation

The mammalian microbiome encodes numerous secondary metabolite biosynthetic gene clusters, yet their role in microbe-microbe interactions is unclear. Here, we characterized two polyketide synthase gene clusters (fun and pks) in the gut symbiont Limosilactobacillus reuteri. The pks, but not the fun cluster, encodes antimicrobial activity. Forty-one out of 51 L. reuteri strains tested are sensitive to Pks products, which was independent of strains’ host origin. The sensitivity to Pks was also established in intraspecies competition experiments in gnotobiotic mice. Comparative genome analyses between Pks-resistant and sensitive strains identified an acyltransferase gene (act) that is unique to Pks-resistant strains. Subsequent peptidoglycan analysis of the wild-type and the act mutant strains showed that Act acetylates peptidoglycan. The pks mutants lost their competitive advantage and act mutants lost their Pks resistance in vivo. Thus, our findings provide mechanistic insights into how closely related gut symbionts can compete and co-exist in the gastrointestinal tract.
A New Reliability Ratio Weighted Bit Flipping Algorithm for Decoding LDPC Codes

In this study, we propose a “New Reliability Ratio Weighted Bit Flipping” (NRRWBF) algorithm for Low-Density Parity-Check (LDPC) codes. This algorithm improves the “Reliability Ratio Weighted Bit Flipping” (RRWBF) algorithm by modifying the reliability ratio. It surpasses the RRWBF in performance, reaching a 0.6 dB coding gain at a Binary Error Rate (BER) of 10−4 over the Additive White Gaussian Noise (AWGN) channel, and presents a significant reduction in the decoding complexity. Furthermore, we improved NRRWBF using the sum of the syndromes as a criterion to avoid the infinite loop. This will enable the decoder to attain a more efficient and effective decoding performance.