Miracle-dz/UniFAR-FTUs huggingface dataset:
Energy misreporting is more prevalent for those of lower socio-economic status and is associated with lower reported intake of discretionary foods

Abstract The role of socio-economic status (SES) on the misreporting of food and energy intakes is not well understood with disagreement in the literature. The aim of this study was to examine the associations between low energy reporting, dietary quality and SES in a representative sample of adults. Dietary data were collected using 2 d of 24-h recalls for 6114 adults aged 19 years and over, participating in the Australian National Nutrition and Physical Activity Survey 2011–2012. Low energy reporters (LER) and plausible reporters (PR) were identified. Discretionary food intake was used as a proxy indicator of diet quality. SES was determined using area-level SES and educational attainment. Regression analysis was applied to examine the effects of LER and SES on diet quality, adjusting for potential confounders. LER was more common in populations of lower SES than higher SES (area-level OR 1·46 (95 % CI 1·06, 2·00); education OR 1·64 (95 % CI 1·28, 2·09). LER and SES were independently associated with diet quality, with LER reporting lower percentage energy from discretionary foods compared with PR (27·4 v. 34·2, P < 0·001), and those of lower area-level SES and education reporting lower diet quality compared with those of higher SES (33·7 v. 31·2, P < 0·001; and 33·5 v. 29·6, P < 0·001, respectively). No interaction effect was found between LER and SES, indicating percentage energy in discretionary foods was not differentially misreported across the SES areas (0·3078) or education (P = 0·7078). In conclusion, LER and higher SES were associated with better diet quality.
Tunable Wettability of Biodegradable Multilayer Sandwich-Structured Electrospun Nanofibrous Membranes

This research aims to develop multilayer sandwich-structured electrospun nanofiber (ENF) membranes using biodegradable polymers. Hydrophilic regenerated cellulose (RC) and hydrophobic poly (lactic acid) (PLA)-based novel multilayer sandwich-structures were created by electrospinning on various copper collectors, including copper foil and 30-mesh copper gauzes, to modify the surface roughness for tunable wettability. Different collectors yielded various sizes and morphologies of the fabricated ENFs with different levels of surface roughness. Bead-free thicker fibers were collected on foil collectors. The surface roughness of the fine fibers collected on mesh collectors contributed to an increase in hydrophobicity. An RC-based triple-layered structure showed a contact angle of 48.2°, which is comparable to the contact angle of the single-layer cellulosic fabrics (47.0°). The polar shift of RC membranes on the wetting envelope is indicative of the possibility of tuning the wetting behavior by creating multilayer structures. Wettability can be tuned by creating multilayer sandwich structures consisting of RC and PLA. This study provides an important insight into the manipulation of the wetting behavior of polymeric ENFs in multilayer structures for applications including chemical protective clothing.
Estudo experimental sobre a disseminação linfática do tumor de Ehrlich na forma sólida em camundongos

As metastases para linfonodos regionais representam fase importante na disseminacao neoplasica. Os mecanismos que concorrem para este processo sao pouco conhecidos, devido provavelmente a escassez de modelos experimentais adequados. O objetivo do presente estudo e o de caracterizar o tumor de Ehrlich como modelo para o estudo da disseminacao linfatica em camundongos. Para tanto, animais foram inoculados com celulas tumorais no coxim plantar e seus linfonodos popliteos foram colhidos varios tempos apos a inoculacao, com a finalidade de avaliar seu peso, aspectos histopatologicos e quantificar os mastocitos, ja que estas celulas parecem estar implicadas na resposta do hospedeiro ao tumor. A migracao das celulas tumorais para os linfonodos popliteos foi detectada a partir de 1 hora apos a inoculacao. 0 crescimento do tunor solido no coxim plantar foi acompanhado ate 30 dias apos a inoculacao, e as alteracoes histopatologicas foram estudadas durante esse periodo. 0 tumor de Ehrlich foi considerado un modelo experimental adequado para o estudo da disseminacao linfatica.
Correlation analysis of cortisol concentration in hair versus concentrations in serum, saliva and urine.

INTRODUCTION Cortisol concentration is measured in blood, urine, and saliva samples. It has been recently proven that cortisol could be also detected in hair samples. Cortisol measurements in different samples have their own individual characteristics and clinical utility. We aimed to investigate the correlation between hair cortisol concentration and standard cortisol measurements used in clinical practice. MATERIAL AND METHODS Fifty adult volunteers with a negative history of endocrine disorders were enrolled into the study. Morning serum cortisol (MSC), evening serum cortisol (ESC), evening free salivary cortisol (EFSC), urine free cortisol (UFC) and hair cortisol were analyzed in all participants. Eventually, 41 volunteers were included into the study, whose cortisol concentration in the 1 mg overnight dexamethason suppression test (1mgONDST) were.
A genetic memory initiates the epigenetic loop necessary to preserve centromere position

Centromeres are built on repetitive DNA sequences (CenDNA) and a specific chromatin enriched with the histone H3 variant CENP‐A, the epigenetic mark that identifies centromere position. Here, we interrogate the importance of CenDNA in centromere specification by developing a system to rapidly remove and reactivate CENP‐A (CENP‐AOFF/ON). Using this system, we define the temporal cascade of events necessary to maintain centromere position. We unveil that CENP‐B bound to CenDNA provides memory for maintenance on human centromeres by promoting de novo CENP‐A deposition. Indeed, lack of CENP‐B favors neocentromere formation under selective pressure. Occasionally, CENP‐B triggers centromere re‐activation initiated by CENP‐C, but not CENP‐A, recruitment at both ectopic and native centromeres. This is then sufficient to initiate the CENP‐A‐based epigenetic loop. Finally, we identify a population of CENP‐A‐negative, CENP‐B/C‐positive resting CD4+ T cells capable to re‐express and reassembles CENP‐A upon cell cycle entry, demonstrating the physiological importance of the genetic memory.
Association between metabolic risk factors and optic disc cupping identified by deep learning method

Purpose This study aims to investigate correlation between metabolic risk factors and optic disc cupping and the development of glaucoma. Methods This study is a retrospective, cross-sectional study with over 20-year-old patients that underwent health screening examinations. Intraocular pressure (IOP), fundus photographs, Body Mass Index (BMI), waist circumference (WC), serum triglycerides, serum HDL cholesterol (HDL-C), serum LDL cholesterol (LDL-C), systolic blood pressure (BP), diastolic BP, and serum HbA1c were obtained to analyse correlation between metabolic risk factors and glaucoma. Eye with glaucomatous optic neuropathy(GON) was defined as having an optic disc with either vertical cup-to-disc ratio(VCDR) ≥ 0.7 or a VCDR difference ≥ 0.2 between the right and left eyes by measuring VCDR with deep learning approach. Results The study comprised 15,585 subjects and 877 subjects were diagnosed as GON. In univariate analyses, age, BMI, systolic BP, diastolic BP, WC, triglyceride, LDL-C, HbA1c, and IOP were significantly and positively correlated with VCDR in the optic nerve head. In linear regression analysis as independent variables, stepwise multiple regression analyses revealed that age, BMI, systolic BP, HbA1c, and IOP showed positive correlation with VCDR. In multivariate logistic analyses of risk factors and GON, higher age (odds ratio [OR], 1.054; 95% confidence interval [CI], 1.046–1.063), male gender (OR, 0.730; 95% CI, 0.609–0.876), more obese (OR, 1.267; 95% CI, 1.065–1.507), and diabetes (OR, 1.575; 95% CI, 1.214–2.043) remained statistically significant correlation with GON. Conclusions Among the metabolic risk factors, obesity and diabetes as well as older age and male gender are risk factors of developing GON. The glaucoma screening examinations should be considered in the populations with these indicated risk factors.
Adaptive Local Adversarial Attacks on 3D Point Clouds for Augmented Reality

As the key technology of augmented reality (AR), 3D recognition and tracking are always vulnerable to adversarial examples, which will cause serious security risks to AR systems. Adversarial examples are beneficial to improve the robustness of the 3D neural network model and enhance the stability of the AR system. At present, most 3D adversarial attack methods perturb the entire point cloud to generate adversarial examples, which results in high perturbation costs and difficulty in reconstructing the corresponding real objects in the physical world. In this paper, we propose an adaptive local adversarial attack method (AL-Adv) on 3D point clouds to generate adversarial point clouds. First, we analyze the vulnerability of the 3D network model and extract the salient regions of the input point cloud, namely the vulnerable regions. Second, we propose an adaptive gradient attack algorithm that targets vulnerable regions. The proposed attack algorithm adaptively assigns different disturbances in different directions of the three-dimensional coordinates of the point cloud. Experimental results show that our proposed method AL-Adv achieves a higher attack success rate than the global attack method. Specifically, the adversarial examples generated by the AL-Adv demonstrate good imperceptibility and small generation costs.
Deploying Offline Reinforcement Learning with Human Feedback

Reinforcement learning (RL) has shown promise for decision-making tasks in real-world applications. One practical framework involves training parameterized policy models from an offline dataset and subsequently deploying them in an online environment. However, this approach can be risky since the offline training may not be perfect, leading to poor performance of the RL models that may take dangerous actions. To address this issue, we propose an alternative framework that involves a human supervising the RL models and providing additional feedback in the online deployment phase. We formalize this online deployment problem and develop two approaches. The first approach uses model selection and the upper confidence bound algorithm to adaptively select a model to deploy from a candidate set of trained offline RL models. The second approach involves fine-tuning the model in the online deployment phase when a supervision signal arrives. We demonstrate the effectiveness of these approaches for robot locomotion control and traffic light control tasks through empirical validation.
An immersive virtual reality game to train spatial attention orientation after stroke: A feasibility study

Abstract Immersive virtual reality (IVR) may boost neglect recovery, as it can provide an engaging experience in a 3D environment. We designed an IVR rehabilitation game for neglect patients using the Oculus Rift. Multisensory cues were presented in the neglected visual field in a patient-tailored way. We acquired pilot data in 15 neurologically healthy controls and 7 stroke patients. First, we compared cybersickness before and after VR exposure. Second, we assessed the user experience through a questionnaire. Third, we tested whether neglect symptoms corresponded between the VR game and a computerized cancelation task. Fourth, we evaluated the effect of the multisensory cueing on target discrimination. Last, we tested two algorithms to tailor the game to the characteristics of the neglected visual field. Cybersickness significantly reduced after VR exposure in six stroke patients and was low in healthy controls. Patients rated the user experience neutral to positive. In addition, neglect symptoms were consistent between a computerized cancelation and VR rehabilitation task. The multisensory cue positively affected target discrimination in the game and we successfully presented sensory stimulation to the neglected visual field in a patient-tailored way. Our results show that it is promising to use gamified patient-tailored immersive VR for neglect rehabilitation.
Characterizing the Role of the miR156-SPL Network in Plant Development and Stress Response

MicroRNA (miRNA) is a short, single-stranded, non-coding RNA found in eukaryotic cells that can regulate the expression of many genes at the post-transcriptional level. Among various plant miRNAs with diverse functions, miR156 plays a key role in biological processes, including developmental regulation, immune response, metabolic regulation, and abiotic stress. MiRNAs have become the regulatory center for plant growth and development. MicroRNA156 (miR156) is a highly conserved and emerging tool for the improvement of plant traits, including crop productivity and stress tolerance. Fine-tuning of squamosa promoter biding-like (SPL) gene expression might be a useful strategy for crop improvement. Here, we studied the regulation of the miR156 module and its interaction with SPL factors to understand the developmental transition of various plant species. Furthermore, this review provides a strong background for plant biotechnology and is an important source of information for further molecular breeding to optimize farming productivity.
Decentralized Privacy-Preserving Data Aggregation Scheme for Smart Grid Based on Blockchain

As a next-generation power system, the smart grid can implement fine-grained smart metering data collection to optimize energy utilization. Smart meters face serious security challenges, such as a trusted third party or a trusted authority being attacked, which leads to the disclosure of user privacy. Blockchain provides a viable solution that can use its key technologies to solve this problem. Blockchain is a new type of decentralized protocol that does not require a trusted third party or a central authority. Therefore, this paper proposes a decentralized privacy-preserving data aggregation (DPPDA) scheme for smart grid based on blockchain. In this scheme, the leader election algorithm is used to select a smart meter in the residential area as a mining node to build a block. The node adopts Paillier cryptosystem algorithm to aggregate the user’s power consumption data. Boneh-Lynn-Shacham short signature and SHA-256 function are applied to ensure the confidentiality and integrity of user data, which is convenient for billing and power regulation. The scheme protects user privacy data while achieving decentralization, without relying on TTP or CA. Security analysis shows that our scheme meets the security and privacy requirements of smart grid data aggregation. The experimental results show that this scheme is more efficient than existing competing schemes in terms of computation and communication overhead.
New Path to Recovery and Well-Being: Cross-Sectional Study on WeChat Use and Endorsement of WeChat-Based mHealth Among People Living With Schizophrenia in China

Background The past few decades have seen an exponential increase in using mobile phones to support medical care (mobile health [mHealth]) among people living with psychosis worldwide, yet little is known about WeChat use and WeChat-based mHealth among people living with schizophrenia (PLS) in China. Objective This study aims to assess WeChat use, endorsement of WeChat-based mHealth programs, and health related to WeChat use among PLS. Methods We recruited a random sample of 400 PLS from 12 communities in Changsha City of Hunan Province, China. WeChat use was assessed using the adapted WeChat Use Intensity Questionnaire (WUIQ). We also compared psychiatric symptoms, functioning, disability, recovery, quality of life, and general well-being between WeChat users and nonusers using one-to-one propensity-score matching. Results The WeChat use rate was 40.8% in this sample (163/400); 30.7% (50/163) had more than 50 WeChat friends and nearly half (81/163, 49.7%) spent more than half an hour on WeChat, a pattern similar to college students and the elderly. PLS also showed higher emotional connectedness to WeChat use than college students. About 80.4% (131/163) of PLS were willing to participate in a WeChat-based mHealth program, including psychoeducation (91/163, 55.8%), professional support (82/163, 50.3%), and peer support (67/163, 41.1%). Compared with nonusers, WeChat users were younger, better educated, and more likely to be employed. WeChat use was associated with improved health outcomes, including lower psychiatric symptoms, lower depression, higher functioning, better recovery, and higher quality of life. Conclusions WeChat-based mHealth programs hold promise as an empowering tool to provide cost-effective interventions, to foster global recovery, and to improve both physical and mental well-being among PLS. WeChat and WeChat-based mHealth programs have the potential to offer a new path to recovery and well-being for PLS in China.
A Single Faecal Microbiota Transplantation Altered the Microbiota of Weaned Pigs

Weaning is a stressful time for piglets, often leading to weight loss and is associated with increased morbidity and mortality. A leading cause for these post-weaning problems is enteric dysbiosis and methods to improve piglet health at this crucial developmental stage are needed. This study aimed to determine whether an enteric dysbiosis caused by weaning could be corrected via a faecal microbiota transplantation (FMT) from healthy piglets from a previous wean. Two or four focal piglets per litter were assigned to one of two treatments; FMT two days post weaning (n = 21; FMT) or a control which received saline two days post weaning (n = 21; CON). FMT consisted of homogenised donor faeces administered orally at 3 mL/kg. Weaning occurred at 18 days of age and weights and faecal samples were collected on days 18, 20, 24 and 35. 16S rRNA amplicon analysis was used to assess the faecal microbiota of piglets. FMT increased Shannon’s diversity post weaning (p < 0.001) and reduced the scratch score observed at 24 days of age (p < 0.001). The bacterial populations significantly differed in composition at each taxonomic level. In FMT pigs, significant increases in potentially pathogenic Escherichia coli were observed. However, increases in beneficial bacteria Lactobacillus mucosae and genera Fibrobacteres and Bacteroidetes were also observed in FMT treated animals. To our knowledge, this is the first study to observe a significant effect on piglet faecal microbiota following a single FMT administered post weaning. Therefore, FMT post weaning can potentially alleviate enteric dysbiosis.
Demographic and Socioeconomic Disparities in Life Expectancy with Hearing Impairment in the U.S.

OBJECTIVES Hearing impairment is one of the most common disabilities among older people, and its prevalence will increase as the U.S. population ages. However, little is known about social disparities in onset or transitions into and out of hearing impairment, nor how these transitions impact years of life to be spent impaired. METHODS We investigate the number of years an "average" person can expect to live with and without hearing impairment after age 50; sex, race, educational, and regional differences in these expectancies; and the implication of hearing impairment for remaining life expectancy. Bayesian multistate life table methods are applied to 9 waves of data from the Health and Retirement Study (1998-2014) to investigate social disparities in life expectancy with hearing impairment (n=20,200) for the general population, people hearing impaired at age 50, and people hearing unimpaired at age 50. RESULTS Men, Hispanics, persons with less educational attainment, and those born in the south can expect to live a larger proportion of their remaining lives hearing impaired. Although transitions from hearing impaired to unimpaired occur, those with some hearing impairment at age 50 can expect to live more years with hearing impairment, and hearing impairment does not shorten remaining life expectancy. DISCUSSION Significant sociodemographic disparities in hearing impaired life expectancy exist. In contrast to past research, we find that hearing impairment does not affect total life expectancy. Future research should consider the consequences of hearing impairment for years to be lived with other age-related and potentially downstream health outcomes.
Construction of the Virtual Embodiment Questionnaire (VEQ)

User embodiment is important for many virtual reality (VR) applications, for example, in the context of social interaction, therapy, training, or entertainment. However, there is no data-driven and validated instrument to empirically measure the perceptual aspects of embodiment, necessary to reliably evaluate this important phenomenon. To provide a method to assess components of virtual embodiment in a reliable and consistent fashion, we constructed a Virtual Embodiment Questionnaire (VEQ). We reviewed previous literature to identify applicable constructs and questionnaire items, and performed a confirmatory factor analysis (CFA) on the data from three experiments (<inline-formula><tex-math notation="LaTeX">$N=196$</tex-math><alternatives><graphic position="float" orientation="portrait" xlink:href="26tvcg12-roth-3023603-eqinline-1-small.tif"/></alternatives></inline-formula>). The analysis confirmed three factors: (1) ownership of a virtual body, (2) agency over a virtual body, and (3) the perceived change in the body schema. A fourth study (<inline-formula><tex-math notation="LaTeX">$N=22$</tex-math><alternatives><graphic position="float" orientation="portrait" xlink:href="26tvcg12-roth-3023603-eqinline-2-small.tif"/></alternatives></inline-formula>) was conducted to confirm the reliability and validity of the scale, by investigating the impacts of latency and latency jitter present in the simulation. We present the proposed scale and study results and discuss resulting implications.
Pellucidin A promotes antinociceptive activity by peripheral mechanisms inhibiting COX-2 and NOS: In vivo and in silico study

Peperomia pellucida (PP) belongs to the Peperomia genus, which has a pantropic distribution. PP is used to treat a wide range of symptoms and diseases, such as pain, inflammation, and hypertension. Intriguingly, PP extract is used by different tropical countries for its anti-inflammatory and antinociceptive effects. In fact, these outcomes have been shown in animal models, though the exact bioactive products of PP that exert such results are yet to be discovered. To determine and elucidate the mechanism of action of one of these compounds, we evaluated the antinociceptive effect of the novel dimeric ArC2 compound, Pellucidin A by using in vivo and in silico models. Animals were then subjected to chemical, biphasic and thermal models of pain. Pellucidin A induced an antinociceptive effect against chemical-induced pain in mice, demonstrated by the decrease of the number of writhes, reaching a reduction of 43% and 65% in animals treated with 1 and 5 mg/kg of Pellucidin A, respectively. In the biphasic response (central and peripheral), animals treated with Pellucidin A showed a significant reduction of the licking time exclusively during the second phase (inflammatory phase). In the hot-plate test, Pellucidin A did not have any impact on the latency time of the treated animals. Moreover, in vivo and in silico results show that Pellucidin A’s mechanism of action in the inflammatory pain occurs most likely through interaction with the nitric oxide (NO) pathway. Our results demonstrate that the antinociceptive activities of Pellucidin A operate under mechanism(s) of peripheral action, involving inflammatory mediators. This work provides insightful novel evidence of the biological properties of Pellucidin A, and leads to a better understanding of its mechanism of action, pointing to potential pharmacological use.