Miracle-dz/UniFAR-FTUs huggingface dataset:
Fluorochrome Interaction with the Mitochondrial Membrane THE EFFECT OF ENERGY CONSERVATION

Abstract The interaction of 1-anilino-8-naphthalenesulfonate and 6-p-toluidino-2-naphthalenesulfonate with the membrane of both mitochondria and submitochondrial particles was studied. A fluorescence increase of the added fluorochromes was observed when energy was supplied to the membrane of submitochondrial particles, while a fluorescence decrease was observed with intact mitochondria. Binding studies and a comparison of the two fluorochromes have indicated that polarity changes of the membrane are not measured by 1-anilino-8-naphthalenesulfonate and 6-p-toluidino-2-naphthalenesulfonate. The fluorescence changes associated with energy conservation can be attributed to changes in the binding of the fluorochromes. Either a conformational change or a membrane potential change could account for the results.
The Practices of Green Supply Chain Management towards Corporate Performances in Construction Industry

Green Supply Chain Management (GSCM) practices has different impact on the corporate performances while practitioners are not willing to implement practices that is irrelevant to their organization. Hence, to ensure the most appropriate investment on GSCM is implemented, this study is conducted to identify the relationship between GSCM practices and corporate performances in Malaysia construction industry. To conduct a literature review to figure the relationship between GSCM practices and corporate performances. Systematic literature review method is adopted in data collection stage. The findings of the study show that the green practices are correlated to the corporate performances and a comprehensive conceptual framework is formed from this study to describe the relationships between GSCM practices and corporate performances in Malaysia construction industry. Research on GSCM in Malaysia is still less in construction industry. However, the findings provide crucial insights for potential practitioners due to it consistency with prior studies which are related to GSCM in other industries and countries. Implementation of GSCM improves corporate performances in various dimensions. The construction industry should understand the functions and relationship of each element in GSCM to achieve best performance outcome in the form they desired. A comprehensive conceptual framework which shows the relationships of GSCM and its impact construction industry which allow the potential practitioners to understand the potential improvement in corporate performances is constructed through the systematic literature review.
Phylogenetic utility of mitochondrial and nuclear genes: a case study in the diptera (true flies)

PHYLOGENETIC UTILITY OF MITOCHONDRIAL AND NUCLEAR GENES: A CASE STUDY IN THE DIPTERA (TRUE FLIES) by JASON CARAVAS May 2012 Advisor: Dr. Markus Friedrich Major: Biological Sciences Degree: Doctor of Philosophy The value of mitochondrial versus nuclear gene sequence data in phylogenetic analysis has received much attention without yielding definitive conclusions. Theoretical arguments and empirical data suggest a lower phylogenetic utility than equivalent nuclear gene sequences, but there are also many examples of important progress made using mitochondrial sequences. We therefore undertook a systematic performance analysis of mitochondrial and nuclear sequence partitions taken from a representative sample of dipteran species. For phylogenetic tree reconstruction, mitochondrial genes performed generally inferior to nuclear genes. However, the mitochondrial genes resolved branches for which nuclear genes failed. Moreover, the combined use of mitochondrial and nuclear sequences produced superior results without artifacts for nodes where mitochondrial and nuclear gene data sets on their own generated conflicting topologies. These findings strongly advocate the inclusion of mitochondrial sequences even in deep phylogeny reconstruction. The comparison of tree support between our and previous analyses identified robustly supported high confidence clades in the Diptera but also a
Periodic event‐triggered control of flywheel energy storage matrix systems for wind farms

Flywheel energy storage plays a significant role in improving the reliability and efficiency of wind farm operations, in recent years. In order to reduce the communication burden, this study proposes a distributed algorithm based on the event triggered to coordinate the operation of wind farm and flywheel energy storage matrix system (FESMS). Different from the traditional sampling mechanism, a periodic sampling-based event-triggered condition, which is based on the disagreement vector and the measurement error, is proposed for the FESMS dispatch problem. Furthermore, a self-triggered method is also studied as well considering the periodic sampling case. The algorithm achieves ratio consensus in a balanced directed graph topology. By simulation, the effectiveness of the proposed algorithm is verified.
Xenobiotic metabolism and zebrafish (danio rerio) larvae

There is a requirement for the characterisation of the metabolism of xenobiotics in zebrafish larvae, due to the application of this organism to toxicity testing and ecotoxicology. Genes similar to mammalian cytochrome P450 (CYP) 1A1, CYP2B6, CYP3A5 and UDP-lucuronosyl-transferase (UGT) 1A1 were demonstrated to be expressed during normal embryonic development, with increased expression post hatching in Wik strain zebrafish larvae (72 hours post fertilisation, hpf). Activities towards ethoxy-resorufin, 7-ethoxy-coumarin and octyloxymethylresorufin, using an in vivo larval assay, were also detected in 96 hpf Wik strain zebrafish larvae, indicative of oxidative and conjugative metabolism. The expression of the identified genes was modulated upon exposure to Aroclor 1254, and the metabolic activities towards ethoxy-resorufin, 7-ethoxy-coumarin and octyloxymethylresorufin were observed to be inducible by exposure to in vitro inhibitors of CYP activities. Wik strain zebrafish larvae (72 hpf) were also demonstrated to metabolise the pharmaceuticals acetaminophen and ibuprofen by oxidative and conjugative processes using liquid chromatography mass spectrometry and scintillation counting. Finally, the organic solvents dimethyl-sulfoxide and methanol were observed to reduce the expression of CYP and UGT genes, and the metabolism of ethoxy-resorufin, after 24 hours exposure to \(\leq\)0.1% volume/volume concentrations of the two solvents. It is suggested that these inhibitory effects are in part due to a reduction in the expression of the aryl hydrocarbon receptors, which are known regulators of drug metabolism genes. Overall the expression of genes and enzymatic activities similar to the mammalian drug metabolism genes have been demonstrated in Wik strain zebrafish larvae (96 hpf), and the first examples of the metabolism of pharmaceuticals by zebrafish larvae are also demonstrated. The modulation of the metabolism of xenobiotics by organic solvents suggests that caution must be exercised when interpreting data from toxicity tests when high solvent concentrations are applied to zebrafish larvae. The continued use of zebrafish larvae as a toxicity testing model is strengthened by the findings of this work.
Behavioral Insights for Foresighted Public Finance

Behavioral insights are becoming part of the policy toolkit in countries around the world, and the IDB has positioned itself at the forefront of this movement in Latin America and the Caribbean. This policy brief discusses some of the reasons behind its success and serves as an encouragement for policymakers in the region to adopt some of these tools. In a region with numerous unfulfilled needs and limited resources, behavioral insights can play an important role for improving public finance in the region. Interventions leveraging behavioral insights can increase revenues by improving tax compliance and boosting tax morale. They can also improve the efficiency of public spending by encouraging preventive healthcare activities (involving vaccines, diet, exercise, etc.), promoting energy and water conservation, lowering traffic fatalities, and reducing teacher absenteeism, among other means. By surveying the evidence coming from interventions in the field in LAC and other parts of the world, this policy brief makes a strong case to the region to embrace behavioral insights and design behaviorally informed policies.
Chapter 6. Non-verbal and multimodal metaphors bring biology into the picture

This electronic file may not be altered in any way. The author(s) of this article is/are permitted to use this PDF file to generate printed copies to be used by way of offprints, for their personal use only. Permission is granted by the publishers to post this file on a closed server which is accessible to members (students and staff) only of the author’s/s’ institute, it is not permitted to post this PDF on the open internet. For any other use of this material prior written permission should be obtained from the publishers or through the Copyright Clearance Center (for USA: www.copyright.com). Please contact rights@benjamins.nl or consult our website: www.benjamins. com
Functional Avian Endocrinology

Preface / Genomic tools for endocrine research / Functional genomics of the avian pineal gland / Transcriptional profiling in liver of hormonally-manipulated chickens / Gene expression profiling in the developing neuroendocrine system of the chick / The gonadotrophin releasing hormone neurone: key to avian reproductive function / Structure, action and functional significance of GnIH / Regulation of FSH secretion: GnRH dependent? / GnRH, photorefractoriness and breeding schedules of cardueline finches / Audio-vocal pathways controlling GnRH release / The possible role of the lateral septal organ in housing encephalic photoreceptors responsible for regulating gonadal development / Photoperiodic time measurement / Environmental control of reproduction in Sonoran Desert Aimophila sparrows / Effects of food availability on the reproductive system / Non-photoperiodic seasonality in a tropical songbird / Melatonin regulation of migratory behaviour and physiology / Melatonin-dependent song pattern of song-birds: Bypassing the gonadal control of sexual behavior / Melatonin regulation of clock genes in birds / Modulation of acute stress in breeding birds / A cardiovascular mechanism for the behavioral effects of AVT during and following acute stress / Corticosterone and memory in birds / Neuroendocrine and behavioral consequences of embryonic exposure to endocrine disrupting chemicals / Endocrine disruption in a songbird, the Zebra finch / Impact of endocrine disrupting chemicals on sexual differentiation in Japanese quail / Growth differentiation factor 9: An oocyte factor regulating ovarian follicle development / The inhibin-activin system and ovarian folliculo-genesis in the chicken / Female mate choice / Activity-dependent regulation of seasonal neuro-plasticity in the song system in songbirds / Modulation of steroid-dependent male sexual behavior and neural gene expression: A role for steroid receptor co-activators / Evolution of plasticity in hormonally-integrated parental tactics: An example with the house finch / Growth hormone: a pituitary and extra pituitary chameleon during development / Ocular pituitary hormones in the chick embryo / CRH control of thyroid function in the chicken / Differential regulation of intracellular thyroid hormone availability in developing chicken brain and peripheral tissues.
Mathematical modeling of chemical signals in inflammatory pathways

Mechanistic, autonomous, ordinary differential equations represent a powerful way to crystalize and reproduce the dynamics of complex, nonlinear interactions. Design and calibration of these models, however, represent a challenge to the construction of fully validated models. Various parameter techniques are employed, evaluated and improved upon for the purpose of fitting in a nonlinear setting. Cells communicate with other cells and their environment by producing and receiving chemical signals. In the context of pathogen response, these signals regulate how the collective of cells reacts. One such undifferentiated response to signal is known as inflammation, and it is an important mediator of pathogen clearance as well as tissue healing; however, it also has the potential to damage the surrounding tissue when regulatory mechanisms break down. Models are built using the mechanisms of these interactions to produce a high level effect, and to predict what measures can be taken, as in influenza, to prevent dysregulation. The models developed for inflammatory response first take into consideration the production and reception of immune factors, cytokines, and then put these mechanisms into the context of tissue level response to external signals and internal signals in the form of system damage. This is incorporated into a nonlinear model of immune response to Influenza A Virus, with innate, adaptive, and humoral immunity components. The model is calibrated against data for both sublethal and lethal initial dosages. A model of mosquito response to exogenous cytokine as immune stimulation is also explored. Successful model fitting using Metropolis-Hastings methods yields multi-objective results for nonlinear deterministic models.
THE DARK SIDE OF CLINICAL TRIALS AND REMEDIAL STRATEGIES IN INDIA

India offers unique benefits to the clinical research fraternity of the world. Breadth of genetic variations, willing subjects due to poverty and abundant research talent brings the world to the door steps of our country. India needs to get its legal framework in to order to check the local exploitation and regulate unscrupulous foreign and domestic researchers. No law is effective unless it is implemented vigorously. Therefore strong executive institutions should be created to implement the laws with severe deterrent punishments. Pharmaceutical practitioners must take this to heart.
Molecular characterization of lactic acid bacteria producing edible biofilm isolated from kimchi

Biofilm is a community of microorganisms that interrelated and covered by an extracellular polymer matrix. This biofilm can be produced by Lactic acid bacteria (LAB) which was edible for human and animal. Therefore, it possible to be applied in the food and health industry. One source of LAB is kimchi, as fermented food from Korea and it has good benefits for health. This research aimed to obtain LAB from kimchi that can produce edible biofilms and to identify LAB producing edible biofilms based on the 16S rRNA gene. Isolation of lactic acid bacteria from kimchi cultured in MRS agar medium containing 1% CaCO3, biofilm production test with biofilm assay method and zeolite as a substrate to adherent cells. For amplification of 16S rRNA gene used primer 27F and 1492R. The isolate of KA2, KA5, KB1, and KC4 isolated from kimchi and could produce biofilms with the highest biofilm formation at 48 hours incubation time. Based on molecular identification with 16S rRNA gene sequencing, the four isolates identified as Lactobacillus brevis species.
What geckos are – an ecological-biogeographic perspective

Geckos are a hyper-diverse, ancient, and globally distributed group. They have diverged early from other squamates and thus can be expected to differ from them along multiple ecological, life history, and biogeographic axes. I review a wide range of gecko traits, comparing them to those of other lizard taxa, to identify the unique, and unifying, attributes of geckos among lizards, based on comprehensive databases of lizard distributions and biological attributes. Few traits completely separate geckos from other lizard taxa, yet they differ to a large degree along many axes: they are more restricted to low latitudes and altitudes, are especially diverse on islands, but relatively scarce in America. They are small lizards, that lay small, fixed clutch sizes, for which they compensate only partially by laying frequently. Because they mature at relatively similar ages and have similar lifespans to other lizards, geckos produce fewer offspring over a year, and over their lifetimes, perhaps implying that they enjoy higher survival rates. While being the only large lizard clade of predominantly nocturnal lizards a large proportion of species is active by day. Gecko body temperatures and preferred temperatures are lower than those of other lizards –even when they are compared to lizards with similar activity times. Worryingly, most geckos have small ranges that often reside completely outside of protected areas – much more frequently than in other reptile and vertebrate taxa.
Supporting English Learners through Practice-Based Research

Learning to use critical practice-based research as part of teaching is an important goal for preservice teachers, especially for those who plan to teach English learners in linguistically diverse settings. In this study, the authors examine the experiences of preservice teachers who were introduced to a framework for enacting iterative, transformative action research and used the framework to study their own teaching in a one-on-one writing partnership with young English learners. Using an established self-efficacy survey instrument, as well as qualitative measures such as course artifacts and observations of teaching, the authors conducted a mixed-methods study to examine the impact of research engagement on preservice teachers’ self-efficacy, self-reported knowledge of practice-based research, and agency. Findings suggest that the experience helped preservice teachers increase their knowledge of practice-based research and reflect on their teaching decisions, but gains in self-efficacy varied across participants in relation to their racial and linguistic positionalities, their understandings of race and language, and their successes and challenges with enacting critically oriented research. This study has important implications for the design of preservice teacher education that emphasizes the role of research in teaching and supports the preparation of teachers for English learners in linguistically diverse communities.
The Effect of Organizational Culture and Company Asset on the Competitive Strategy of the Diving Industry in Indonesia

Purpose: This study aims to examine the influence of organizational culture and company assets on the competitive strategy of the diving industry in Indonesia. Design/Methodology/Approach: This study uses quantitative methods. The unit of analysis is a dive operator in Indonesia. The observation unit is the management of dive operators in Indonesia which can be represented by middle-level managers or management. According to the Indonesian Diving Tourism Business Association (PUWSI), in 2017 there were 284 dive operators. In this study, a sample of 50 respondents was used. Primary data is obtained from the results of direct research in the field, namely data from questionnaires distributed to dive operators in Indonesia. Data and information collected at the time horizon are cross section one shoot. Causality research is used to obtain an evidence of a causal relationship between variables, using Partial Least Square (PLS). Findings: The research findings show that organizational culture and company assets influence the competitive strategy of the diving industry. Company assets have a more dominant influence than organizational culture in improving competitive strategy. Practical Implications: This finding is expected to have implications for the management of diving industry companies in Indonesia as an alternative model of solutions in improving a competitive strategy based on the development of company assets and organizational culture. Originality/Value: The aspects that must be the first priority in developing company assets are intangible assets, while in developing organizational culture, management needs to prioritize the development of stability and control within the organization.
Metabolic rates and feeding behaviour of sprat, Sprattus sprattus L.

Sprat, Sprattus sprattus L. , is a small schooling clupeid forming large stocks in several ecosystems. Despite its high trophodynamic impact, little is known about its energy consumption rates. As a central component of a bioenergetic budget metabolic rates of sprat from 3.11 to 9.71 g wet weight (WW) were measured at 9 different temperatures (T) ranging from 9-21°C using a computer controlled intermittent-flow respirometer. Routine metabolism (RR) was related to T (°C) and WW (g) by RR=0.074 WW 1.077 e 0.080 . Standard metabolic rates (Rs) as calculated from the 10% percentiles of the repeated measurements were on average 12% lower and still influenced by continuous swimming activity: RS=0.069 WW 1.073 e 0.078 . We interpret the deviation of the scaling exponent b from typically found exponents of b ~ 0.8 as a consequence of permanently elevated activity level. The high permanent swimming activities also indicated that the concept of standard metabolism may not be meaningful in schooling planktivorous fish. These results suggest that generally in bioenergetic models for clupeid schooling fish the activity multipliers should be chosen very conservatively. Original copyright by Springer Science and Business Media. Reprint with kind permission of Springer Science and Business Media. For citations use the original manuscript. *corresponding author: laura.meskendahl@uni-hamburg.de
Interactions between benthic macroinvertebrates and saltmarsh plants : consequences for saltmarsh restoration and the policy of managed realignment on the coast of SE England.

Over the last half century, the saltmarshes of south east England have undergone an extensive decline, especially the pioneer zone vegetation. These losses have generally been blamed on coastal squeeze resulting from sea level rising against sea walls. There is little evidence to support this hypothesis however, and an alternative hypothesis, based on infaunal invertebrates preventing the establishment of saltmarsh plants was tested. In the managed realignment site at Tollesbury, and the other sites examined, the mudflat fauna was dominated by Nereis (= Hediste) diversicolor and Hydrobia ulvae. In laboratory experiments, N. diversicolor and H. ulvae reduced the production of seedlings from seeds of Salicornia europaea agg. Conversely the presence of S. europaea agg. significantly reduced the normal burrowing activity of N. diversicolor. Invertebrate exclusion experiments established at five sites in south east England facilitated colonisation by saltmarsh plants at some sites (Orplands, the Blythe Estuary, Wallasea Island and Maldon), by excluding large (>3cm) N. diversicolor. However, at the Tollesbury realignment site, the high rate of sediment deposition and the relatively long distance to a source of seeds prevented plant colonisation. This study supports the hypothesis that establishment of saltmarsh vegetation is prevented by infaunal invertebrates, particularly N. diversicolor, which exclude plants through bioturbation, herbivory and granivory. These interactions may help explain the loss of saltmarshes and will reduce the success of future managed realignment schemes which depend upon the colonisation of new intertidal areas by saltmarsh vegetation. Further management of . realignment sites will be necessary to encourage saltmarsh development.