Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical criteria for systemic lupus erythematosus precede diagnosis, and associated autoantibodies are present before clinical symptoms.

OBJECTIVE Specific events that occur during the development of systemic lupus erythematosus (SLE) can be quite variable among individual patients. The aim of this study was to identify patterns that distinguish early clinical events in SLE and to assess whether the presence of associated autoantibodies precedes the fulfillment of clinical criteria. METHODS Through a retrospective chart review of military medical records, 130 patients who met the American College of Rheumatology (ACR) criteria for the classification of SLE were identified. The initial time at which each criterion was fulfilled was recorded. Autoantibody analysis was performed on serum samples, using enzyme-linked immunosorbent assays or immunofluorescence. RESULTS The clinical features that were observed earliest were discoid rash and seizures, which developed a mean 1.74 and 1.70 years, respectively, before the diagnosis of SLE; however, arthritis was the criterion that was most commonly observed before diagnosis. The presence of IgG rheumatoid factor (IgG-RF) preceded the development of arthritis in 15 (94%) of the 16 patients who were positive for IgG-RF and in whom arthritis developed (Z = 10.2, P < 0.0001). Analogously, IgM-RF appeared before the development of arthritis in 13 (76%) of 17 patients. Anti-double-stranded DNA antibodies were associated with renal disease and appeared before evidence of nephritis in most patients (92%) (Z = 13.3, P < 0.0001). An analysis of the appearance of autoantibodies compared with the appearance of clinical criteria not associated with them revealed no significant temporal relationship. CONCLUSION Symptoms associated with the ACR criteria for classification of SLE are commonly present before the diagnosis of SLE, and development of organ-associated autoantibodies generally precedes the appearance of their associated clinical features.
Predictive Abuse Detection for a PLC Smart Lighting Network Based on Automatically Created Models of Exponential Smoothing

One of the basic elements of a Smart City is the urban infrastructure management system, in particular, systems of intelligent street lighting control. However, for their reliable operation, they require special care for the safety of their critical communication infrastructure. This article presents solutions for the detection of different kinds of abuses in network traffic of Smart Lighting infrastructure, realized by Power Line Communication technology. Both the structure of the examined Smart Lighting network and its elements are described. The article discusses the key security problems which have a direct impact on the correct performance of the Smart Lighting critical infrastructure. In order to detect an anomaly/attack, we proposed the usage of a statistical model to obtain forecasting intervals. Then, we calculated the value of the differences between the forecast in the estimated traffic model and its real variability so as to detect abnormal behavior (which may be symptomatic of an abuse attempt). Due to the possibility of appearance of significant fluctuations in the real network traffic, we proposed a procedure of statistical models update which is based on the criterion of interquartile spacing. The results obtained during the experiments confirmed the effectiveness of the presented misuse detection method.
FAM198B Is Associated with Prolonged Survival and Inhibits Metastasis in Lung Adenocarcinoma via Blockage of ERK-Mediated MMP-1 Expression

Purpose: The comprehensive understanding of mechanisms involved in the tumor metastasis is urgently needed for discovering novel metastasis-related genes for developing effective diagnoses and treatments for lung cancer. Experimental Design: FAM198B was identified from an isogenic lung cancer metastasis cell model by microarray analysis. To investigate the clinical relevance of FAM198B, the FAM198B expression of 95 Taiwan lung adenocarcinoma patients was analyzed by quantitative real-time PCR and correlated to patients' survivals. The impact of FAM198B on cell invasion, metastasis, and tumor growth was examined by in vitro cellular assays and in vivo mouse models. In addition, the N-glycosylation–defective FAM198B mutants generated by site-directed mutagenesis were used to study protein stability and subcellular localization of FAM198B. Finally, the microarray and pathway analyses were used to elucidate the underlying mechanisms of FAM198B-mediated tumor suppression. Results: We found that the high expression of FAM198B was associated with favorable survival in Taiwan lung adenocarcinoma patients and in a lung cancer public database. Enforced expression of FAM198B inhibited cell invasion, migration, mobility, proliferation, and anchorage-independent growth, and FAM198B silencing exhibited opposite activities in vitro. FAM198B also attenuated tumor growth and metastasis in vivo. We further identified MMP-1 as a critical downstream target of FAM198B. The FAM198B-mediated MMP-1 downregulation was via inhibition of the phosphorylation of ERK. Interestingly deglycosylation nearly eliminated the metastasis suppression activity of FAM198B due to a decrease of protein stability. Conclusions: Our results implicate FAM198B as a potential tumor suppressor and to be a prognostic marker in lung adenocarcinoma. Clin Cancer Res; 24(4); 916–26. ©2017 AACR.
Future Osteoporotic Fracture Risk Related to Lumbar Vertebral Trabecular Attenuation Measured at Routine Body CT

We sought to determine if vertebral trabecular attenuation values measured on routine body computed tomography (CT) scans obtained for a variety of unrelated indications can predict future osteoporotic fractures at multiple skeletal sites. For this Health Insurance Portability and Accountability Act (HIPAA)‐compliant and Institutional Review Board (IRB)‐approved retrospective cohort study, trabecular attenuation of the first lumbar vertebra was measured in 1966 consecutive older adults who underwent chest and/or abdominal CT at a single institution over the course of 1 year. New pathologic fragility fractures that occurred after a patient's CT study date were identified through an electronic health record database query using International Classification of Diseases (ICD)‐9 codes for vertebral, hip, and extremity fractures. Univariate and multivariate Cox proportional hazards regression were performed to determine the effect of L1 trabecular attenuation on fracture‐free survival. Age at CT, sex, and presence of a prior fragility fracture were included as confounders in multivariate survival analysis. Model discriminative capability was assessed through calculation of an optimism‐corrected concordance index. A total of 507 patients (mean age 73.4 ± 6.3 years; 277 women, 230 men) were included in the final analysis. The median post‐CT follow‐up interval was 5.8 years (interquartile range 2.1–11.0 years). Univariate analysis showed that L1 attenuation values ≤90 Hounsfield units (HU) are significantly associated with decreased fracture‐free survival (p < 0.001 by log‐rank test). After adjusting for age, sex, prior fracture, glucocorticoid use, bisphosphonate use, chronic kidney disease, tobacco use, ethanol abuse, cancer history, and rheumatoid arthritis history, multivariate analysis demonstrated a persistent modest effect of L1 attenuation on fracture‐free survival (hazard ratio [HR] = 0.63 per 10‐unit increase; 95% confidence interval [CI] 0.47–0.85). The model concordance index was 0.700. Ten‐year probabilities for major osteoporosis‐related fractures straddled the treatment threshold for most subcohorts over the observed L1 HU range. In conclusion, for patients undergoing body CT scanning for any indication, L1 vertebral trabecular attenuation is a simple measure that, when ≤90 HU, identifies patients with a significant decrease in fracture‐free survival. © 2018 American Society for Bone and Mineral Research.
Critical evaluation of bioinformatics tools for the prediction of protein crystallization propensity

&NA; X‐ray crystallography is the main tool for structural determination of proteins. Yet, the underlying crystallization process is costly, has a high attrition rate and involves a series of trial‐and‐error attempts to obtain diffraction‐quality crystals. The Structural Genomics Consortium aims to systematically solve representative structures of major protein‐fold classes using primarily high‐throughput X‐ray crystallography. The attrition rate of these efforts can be improved by selection of proteins that are potentially easier to be crystallized. In this context, bioinformatics approaches have been developed to predict crystallization propensities based on protein sequences. These approaches are used to facilitate prioritization of the most promising target proteins, search for alternative structural orthologues of the target proteins and suggest designs of constructs capable of potentially enhancing the likelihood of successful crystallization. We reviewed and compared nine predictors of protein crystallization propensity. Moreover, we demonstrated that integrating selected outputs from multiple predictors as candidate input features to build the predictive model results in a significantly higher predictive performance when compared to using these predictors individually. Furthermore, we also introduced a new and accurate predictor of protein crystallization propensity, Crysf, which uses functional features extracted from UniProt as inputs. This comprehensive review will assist structural biologists in selecting the most appropriate predictor, and is also beneficial for bioinformaticians to develop a new generation of predictive algorithms.
Body map of regional vs. whole body sweating rate and sweat electrolyte concentrations in men and women during moderate exercise-heat stress.

This study determined the relations between regional (REG) and whole body (WB) sweating rate (RSR and WBSR, respectively) as well as REG and WB sweat Na+ concentration ([Na+]) during exercise. Twenty-six recreational athletes (17 men, 9 women) cycled for 90 min while WB sweat [Na+] was measured using the washdown technique. RSR and REG sweat [Na+] were measured from nine regions using absorbent patches. RSR and REG sweat [Na+] from all regions were significantly ( P < 0.05) correlated with WBSR ( r = 0.58-0.83) and WB sweat [Na+] ( r = 0.74-0.88), respectively. However, the slope and y-intercept of the regression lines for most models were significantly different than 1 and 0, respectively. The coefficients of determination ( r2) were 0.44-0.69 for RSR predicting WBSR [best predictors: dorsal forearm ( r2 = 0.62) and triceps ( r2 = 0.69)] and 0.55-0.77 for REG predicting WB sweat [Na+] [best predictors: ventral forearm ( r2 = 0.73) and thigh ( r2 = 0.77)]. There was a significant ( P < 0.05) effect of day-to-day variability on the regression model predicting WBSR from RSR at most regions but no effect on predictions of WB sweat [Na+] from REG. Results suggest that REG cannot be used as a direct surrogate for WB sweating responses. Nonetheless, the use of regression equations to predict WB sweat [Na+] from REG can provide an estimation of WB sweat [Na+] with an acceptable level of accuracy, especially using the forearm or thigh. However, the best practice for measuring WBSR remains conventional WB mass balance calculations since prediction of WBSR from RSR using absorbent patches does not meet the accuracy or reliability required to inform fluid intake recommendations. NEW & NOTEWORTHY This study developed a body map of regional sweating rate and regional (REG) sweat electrolyte concentrations and determined the effect of within-subject (bilateral and day-to-day) and between-subject (sex) factors on the relations between REG and the whole body (WB). Regression equations can be used to predict WB sweat Na+ concentration from REG, especially using the forearm or thigh. However, prediction of WB sweating rate from REG sweating rate using absorbent patches does not reach the accuracy or reliability required to inform fluid intake recommendations.
Association of single nucleotide polymorphisms in WNT genes with the risk of nonsyndromic cleft lip with or without cleft palate

Nonsyndromic cleft lip with or without cleft palate is a common congenital deformity worldwide with multifaceted etiology. Interaction of genes and environmental factors has been indicated to be related with susceptibility to nonsyndromic cleft lip with or without cleft palate. Some WNT genes which are involved in craniofacial embryogenesis may play a key role in the pathogenesis of nonsyndromic cleft lip with or without cleft palate. In the present study, we aimed to inspect the relationship between WNT3 (rs3809857 and rs9890413), WNT3A (rs752107 and rs3121310), and WNT10a rs201002930 (c.392 C>T) polymorphisms and nonsyndromic cleft lip with or without cleft palate in an Iranian population. The present case‐control study was carried out on 120 unrelated nonsyndromic cleft lip with or without cleft palate patients and 112 healthy subjects. The variants were genotyped by polymerase chain reaction‐restriction fragment length polymorphism method. The findings suggest that the rs3809857 polymorphism significantly decreased the risk of nonsyndromic cleft lip with or without cleft palate in codominant (odds ratio = 0.16, 95% confidence interval = 0.03–0.75, P = 0.020, TT vs GG), recessive (odds ratio = 0.16, 95% confidence interval = 0.03–0.72, P = 0.009, TT vs GG + GT) inheritance models. The rs9890413 variant marginally decreased the risk of nonsyndromic cleft lip with or without cleft palate in codominant (odds ratio = 0.41, 95% confidence interval = 0.17–0.99, P = 0.047, AG vs AA) model. Regarding C392T variant, the findings revealed that this variant significantly decreased the risk of nonsyndromic cleft lip with or without cleft palate in codominant (odds ratio = 0.24, 95% confidence interval = 0.10–0.58, P = 0.002, CT vs CC) and allele (odds ratio = 0.26, 95% confidence interval = 0.11–0.62, P = 0.002, T vs C) models. No significant association was observed between the rs752107 and rs3121310 variants and risk/protection of nonsyndromic cleft lip with or without cleft palate. Stratified analysis showed that WNT10a rs201002930 (c.392 C>T) significantly decreased the risk of cleft lip with cleft palate and cleft palate only. In summary, the results suggest an association between WNT genes polymorphisms and the risk nonsyndromic cleft lip with or without cleft palate in a sample of the southeast Iranian population.
Expression of Fc Gamma Receptor III (CD16) on Monocytes during Hemodialysis in Patients with Chronic Renal Failure

Background/Aims: Circulating CD14+CD16+ monocytes, a potent phagocytosing and antigen-presenting monocyte population, have been reported to be expanded in patients on hemodialysis (HD). In this study, changes in the population of CD14+CD16+ monocytes were analyzed during a single session of HD therapy, and the influence of dialyzer membrane materials on these monocytes was investigated. Methods: Nine patients were hemodialyzed using regenerated cellulose (RC) membranes and thereafter polysulfone (PS) membranes. Peripheral blood cells were taken from these subjects, and these cells were stained with anti-CD14 and anti-CD16 antibodies. The percentages of CD14- and CD16-expressing monocytes were analyzed by two-color flow cytometric analysis. Moreover, the serum soluble CD14 (sCD14) levels were measured with an ELISA kit. Results: It was found that CD14+CD16+ monocytes before HD were significantly increased in patients on HD as compared to healthy controls. In the RC group, CD14+CD16+ monocytes were decreased at both 30 and 240 min after the initiation of HD. The reduction rate of CD14+CD16+ monocytes in the RC group was higher than that in the PS group. There was no significant difference in sCD14 levels between the two groups. Conclusion: Monocytes are activated in patients on HD. Furthermore, the population of CD14+CD16+ monocytes was stimulated to a greater extent during HD in the RC group than in the PS group. The significant reduction in CD14+CD16+ monocytes by RC membranes indicated that the level of CD14+CD16+ monocytes is a sensitive marker for the biocompatibility of HD membranes.
Analytical approach of permittivity and permeability of spiral-resonator shaped planar structure implemented as antenna radiator

This paper presents analytical approach of permittivity and permeability of planar structure which takes a shape of spiral-resonator (SR) implemented as an antenna radiator. The use of planar structure for instance as an antenna radiator is recently required in order to have communication devices with compact and light in weight. The approach is carried out by calculating the effective impedance of SR shaped planar structure through its equivalent circuit which consists of resistance, inductance, and capacitance. Afterwards, the effective permittivity and permeability are obtained. To verify the proposed analytical approach, the SR shaped planar structure is also characterized using 3D simulation software to gain the effective permittivity and permeability. It shows that the effective permittivity and permeability which are yielded from simulation and analytical approach have good agreement each other for positive permittivity (μ > 0) and negative permeability (μ < 0) at the frequency range above 0.8 GHz.
The Impact of Sentiment Orientations on Successful Crowdfunding Campaigns through Text Analytics

The sentiment implied in user generated content represents the authors' personality, attitude, education level and social status. In Crowdfunding, the sentimental factor of the text description may impact the backers' investment intention on the project. The authors study the textual description from the sentimental aspect on the pledge results by employing text mining. The study proves that positive sentiment in the blurb and detailed description promotes the successful campaigns while it should not contain any sentimental factor in title. The predictive analysis shows that the predictive accuracy can be improved 7% based on the baseline model after considering sentimental factors from 64.4% to 71.7%.
Topic embedding of sentences for story segmentation

In this paper, we propose to embed sentences into fixed-dimensional vectors that carry the topic information for story segmentation. As a sentence comprises of a sequence of words and may have different lengths, we use long short-term memory recurrent neural network (LSTM-RNN) to summarize the information of the whole sentence and only predict the topic class at the last word in the sentence. The output of the network at the last word can be used as an embedding of the sentence in the topic space. We used the obtained sentence embeddings in the HMM-based story segmentation framework and obtained promising results. On the TDT2 corpus, the F1 measure is improved to 0.789 from 0.765 which is obtained by a competitive system using DNN and bag-of-words features.
Enhancing Theoretical Fidelity: An E-mail—Based Walking Program Demonstration

Purpose. To examine the extent to which theoretical fidelity, or precision in replicating theory-based recommendations, influenced the effectiveness of two walking programs based on social cognitive theory (SCT). Design. Two-group randomized controlled trial. Setting. College town in Virginia. Subjects. Sixty-one sedentary adult women. Intervention. Two 12-week e-mail–based walking programs were compared. The high fidelity program was designed to more precisely follow SCT recommendations for operationalizing mastery procedures than the low fidelity program, which was designed to simulate how mastery procedures were operationalized in most existing SCT-based physical activity programs. Treatment contact and walking prescription were controlled across groups. Measures. The 1-mile walk test of physical fitness and SCT measures were completed at baseline and posttest. Self-reported walking quantity was assessed at baseline, posttest, and 1-year follow-up. Walking logs were completed during the program. Process evaluation measures were completed at posttest. Results. Fifty women completed the study. The high fidelity group improved more than twice as much as the low fidelity group on 1-mile walk test time (86 vs. 32 seconds, p < .05), goal setting (p < .05), and positive outcome expectations (p < .05) and reported greater program satisfaction (p < .01). Conclusion. Theoretical fidelity could advance the quality of physical activity interventions, which have often shown small effects.
Exploring the Effects of Working Memory on Time Perception in Attention Deficit Hyperactivity Disorder

Children with attention deficit hyperactivity disorder (ADHD) are often reported to have deficits of time perception. However, there is a strong relation between performance on tasks of working memory and time perception. Thus, it is possible that the poor performance of children with ADHD on time perception results from their deficit of working memory. In this study, the working memory of participants was separately assessed; therefore, we could explore the relationship between working memory and time perception of children with ADHD. Fifty-six children with ADHD and those of healthy controls completed tasks measuring working memory and time perception. The results showed that the time discrimination ability of children with ADHD was poorer than that of controls. However, there was a strong association between time perception and working memory. After controlling working memory and intelligence, the time discrimination ability of children with ADHD was not significantly poorer than that of controls. We suggest that there is an interdependent relationship between time perception and working memory for children with ADHD.
Automated fundamental heart sound detection using spectral clustering technique

For automated analysis of heart sound the first and essential step is detection of the position of fundamental heart sounds (S1 and S2) within a Phonocardiogram (PCG) signal. In this study we propose an acoustic feature based technique for efficient localization of S1-S2 and non S1-S2 segments of a PCG signal. While envelop extraction based methods have been shown moderate successful outcomes, we have proposed a spectral clustering based technique which uses the power spectral density (PSD) as the input feature. The clustering algorithm has been utilized to group the signal into two clusters. Proposed method has been obtained a high true positive rate of 99.45% and low false alarm of 0.14%.
Renal Responses to a Series of Handball Games Played in Sub-Saharan Environment by Amateur Division 1 of Female Players

This study aims at assessing the modifications of renal parameters with 13 female players of the same Benin team-amateur Division 1, during two consecutive handball games played 26 hours apart. The players are divided into two groups: starters (ST: N = 7) and nonstarters (NS: N = 6). The estimated glomerular filtration rate (eGFR) with Cockcroft-Gault and MDRD formulas, the fractional excretion of sodium (FeNa), the plasma haemoglobin (Hb) and albumin (Alb) were assayed at rest and at the end of each game. At the end of the first game, only eGFR decreased significantly by at least 16.30% (p ＜ 0.05) in ST only. At the end of the second game, the average reductions of eGFR are significant in both the ST and NS groups (p ＜ 0.05), but they are less important than those recorded at the end of the first (p ＞ 0.05). FeNa varied in no group, neither after the first game, nor after the second (p ＞ 0.05). But a cumulative reduction is observed between the values before the first and those recorded at the end of the second game in both ST and NS groups. The status of the players (ST or NS) did not influence the results. Two games of handball played 26 hours apart in the sub-Saharan environment of Cotonou caused in girls, a transitory decrease in eGFR without a cumulative effect. FeNa decreased too, but with a cumulative effect which indicates large sodium retention.