Miracle-dz/UniFAR-FTUs huggingface dataset:
Unsupervised Grouping of Local Components for Object Segmentation

In this paper, we propose a novel object segmentation method for image understanding. Due to challenges such as variations in object size, orientation, illumination etc. object segmentation is extraordinarily difficult task in the domain of image understanding. It is well-founded concept that a small portion of the pixel set in an image contributes most in image description. Based on this concept, we hypothesize that an image consists of many components or parts each of which represent a small local area in the image and they are very meaningful in visual perception. For object segmentation, we propose spatial segmentation method on such prototypical components of images. Given an image this segmentation method acts as coarse to fine search for object(s) iteratively. The proposed method demonstrate its excellence in localizing objects in various complex backgrounds, multiple objects in a single image even if they have variation in size, orientation, lighting conditions etc. The detection efficiency of our object detector on our self-collected image set which consists of images from six different object categories climbs up to 93% in average.
Title : A new approach to forecasting mountain wave induced clear air turbulence Short title : Forecasting mountain wave induced clear air turbulence

Mountain wave breaking in the lower stratosphere is one of the major causes of atmospheric turbulence encountered in commercial aviation – the cause of most weather-related aircraft incidents. In the case of clear air turbulence (CAT), there are no visual clues and pilots are reliant on operational forecasts and reports from other aircraft. Traditionally mountain waves have been sub-grid-scale in global forecast models, but recent developments mean that some NWP models (e.g. the UK Met Office Unified Model; MetUM) are now able to resolve mountain wave activity explicitly, allowing forecasts of mountain wave induced turbulence with greater accuracy and confidence than previously possible. Despite this, the characteristically fine-scale phenomenon of mountain wave breaking is still unlikely to be resolved by global models. Accordingly, a modified turbulent kinetic energy (TKE) diagnostic is derived, designed to identify regions which are likely to be turbulent. Using the MetUM and automated observations from commercial aircraft, this diagnostic is shown to provide useful forecasts of CAT during three case studies over Greenland, and to outperform the current operational Met Office CAT prediction product in doing so. In a long term, 17-month verification, forecasts based on the TKE diagnostic yield a turbulence prediction hit rate of 80 % with an accompanying false alarm rate of under 40 %; a considerable improvement on the current operational product. The major implication of this work is that sophisticated global NWP models are now sufficiently advanced that skilful forecasts can be made of mountain wave turbulence.
Pleura and Peritoneum

Background: Neutropenia and thrombocytopenia are wellrecognised complications of systemic chemotherapy. In cytoreductive surgery and heated intraperitoneal chemotherapy (HIPEC), the interplay between surgical factors and systemic toxicity of chemotherapeutics must be considered when considering post-operative haematological outcomes. We sought to quantify the incidence of these events in cytoreductive surgery and HIPEC at our institution. Methods: We conducted a single centre, a retrospective cohort study of 50 consecutive patients who underwent cytoreductive surgery and HIPEC from 2002 to 2015. Routine haematological data were analysed and complications classified according to CTCAE 4.0. Subgroup analysis was undertaken to compare those who received or not perioperative systemic chemotherapy. Results: The rate of all-grade post-procedure neutropenia was 4% (n = 2/50); one grade 1, and one grade 4 neutropenia. The patient with grade 4 neutropenia died day 57 post-operatively, despite subsequent growth factor support. Eight percent (n = 4/50) of patients had thrombocytopenia preoperatively. The overall rate of post-procedure thrombocytopenia was 46% with grade 3–4 thrombocytopenia of 4%. If not present preoperatively, thrombocytopenia onset was on day 1 or 2 post-operatively, with a median duration of 3 days. Conclusions: Intraperitoneal delivery of chemotherapy as HIPEC can cause haematological toxicity with potentially fatal outcomes. However, the incidence of neutropenia and thrombocytopenia after CRS and HIPEC is low.
Sex Differences in the Neural Correlates of Spatial Context Memory Decline in Healthy Aging

Aging is associated with episodic memory decline and alterations in memory-related brain function. However, it remains unclear if age-related memory decline is associated with similar patterns of brain aging in women and men. In the current task fMRI study, we tested the hypothesis that there are sex differences in the effect of age and memory performance on brain activity during episodic encoding and retrieval of face–location associations (spatial context memory). Forty-one women and 41 men between the ages of 21 and 76 years participated in this study. Between-group multivariate partial least squares analysis of the fMRI data was conducted to directly test for sex differences and similarities in age-related and performance-related patterns of brain activity. Our behavioral analysis indicated no significant sex differences in retrieval accuracy on the fMRI tasks. In relation to performance effects, we observed similarities and differences in how retrieval accuracy related to brain activity in women and men. Both sexes activated dorsal and lateral PFC, inferior parietal cortex, and left parahippocampal gyrus at encoding, and this supported subsequent memory performance. However, there were sex differences in retrieval activity in these same regions and in lateral occipital-temporal and ventrolateral PFC. In relation to age effects, we observed sex differences in the effect of age on memory-related activity within PFC, inferior parietal cortex, parahippocampal gyrus, and lateral occipital-temporal cortices. Overall, our findings suggest that the neural correlates of age-related spatial context memory decline differ in women compared with men.
Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease

Background Oxidative stress modulates insulin resistant-related atherogenic dyslipidemia: hypertriglyceridemia (HTG) and low high-density lipoprotein cholesterol (HDL-C) level. Gene polymorphisms in superoxide dismutase (SOD2 and SOD3), glutathione peroxidase-3 (GPX3), and glutathione S-transferase theta-1 (GSTT1) may enable oxidative stress-related lipid abnormalities and severity of coronary atherosclerosis. The present study investigated the associations of antioxidant-related gene polymorphisms with atherogenic dyslipidemia and atherosclerotic severity in subjects with high risk of coronary artery disease (CAD). Methods Study population comprises of 396 subjects with high risk of CAD. Gene polymorphisms: SOD2 rs4880, SOD3 rs2536512 and rs2855262, GPX rs3828599, and GSTT1 (deletion) were evaluated the associations with HTG, low HDL-C, high TG/HDL-C ratio, and severity of coronary atherosclerosis. Results SOD2 rs4880-CC, SOD3 rs2536512-AA, rs2855262-CC, and GPX3 rs3828599-AA, but not GSTT1-/- individually increased risk of HTG combined with low HDL-C level. With a combination of five risk-genotypes as a genetic risk score (GRS), GRS ≥ 6 increased risks of low HDL-C, high TG/HDL-C ratio, and HTG combined with low HDL-C, comparing with GRS 0–2 [respective adjusted ORs (95% CI) = 2.70 (1.24–5.85), 3.11 (1.55–6.23), and 5.73 (2.22–14.77)]. Gene polymorphisms, though, were not directly associated with severity of coronary atherosclerosis; high TG/HDL-C ratio was associated with coronary atherosclerotic severity [OR = 2.26 (95% CI [1.17–4.34])]. Conclusion Combined polymorphisms in antioxidant-related genes increased the risk of dyslipidemia related to atherosclerotic severity, suggesting the combined antioxidant-related gene polymorphisms as predictor of atherogenic dyslipidemia.
Long-term warming results in species-specific shifts in seed mass in alpine communities

Background Global warming can cause variation in plant functional traits due to phenotypic plasticity or rapid microevolutionary change. Seed mass represents a fundamental axis of trait variation in plants, from an individual to a community scale. Here, we hypothesize that long-term warming can shift the mean seed mass of species. Methods We tested our hypothesis in plots that had been warmed over 18 years in alpine meadow communities with a history of light grazing (LG) and heavy grazing (HG) on the Qinghai-Tibet plateau. In this study, seeds were collected during the growing season of 2015. Results We found that warming increased the mean seed mass of 4 (n = 19) species in the LG meadow and 6 (n = 20) species in the HG meadow, while decreasing the mean seed mass of 6 species in the LG and HG meadows, respectively. For 7 species, grazing history modified the effect of warming on seed mass. Therefore, we concluded that long-term warming can shift the mean seed mass at the species level. However, the direction of this variation is species-specific. Our study suggests that mean seed mass of alpine plant species appears to decrease in warmer (less stressful) habitats based on life-history theory, but it also suggests there may be an underlying trade-off in which mean seed mass may increase due to greater thermal energy inputs into seed development. Furthermore, the physical and biotic environment modulating this trade-off result in complex patterns of variation in mean seed mass of alpine plant species facing global warming.
Recurrent Hematomas following a Revision Total Hip Arthroplasty in Acquired Coagulation Factor XIII Deficiency

Coagulation factor XIII (FXIII) is the final enzyme in the coagulation cascade and plays an important role in catalyzing the intermolecular cross-linking of fibrin polymers. FXIII deficiency is a rare disorder that presents with recurrent soft tissue bleeding. In this case report, we describe a patient with recurrent hematomas, following a revision total hip arthroplasty (THA). A 50-year-old female patient with no past history of bleeding and with a normal perioperative coagulation profile presented with recurrent hip joint hematomas. Her plasma FXIII activity showed a slight decrease (69%). Therefore, the patient was diagnosed with an acquired deficiency and was administered FXIII to correct it. The bleeding did not recur once the FXIII activity had returned to a normal level (76%). At 2 months after the second evacuation procedure, the patient was discharged from the hospital in an ambulatory state. There has been no recurrence of a hematoma since. We managed a rare case of acquired FXIII deficiency, which highlighted that a patient can present with an acquired bleeding disorder despite having a normal coagulation profile. An acquired FXIII deficiency should be suspected in patients with inexplicable, sudden-onset bleeding, as early diagnosis and treatment are important to prevent life-threatening complications.
Classification, History, and Future Prospects of Maxillofacial Prosthesis

This review presents a classification system for maxillofacial prostheses, while explaining its types. It also aims to describe their origin and development, currently available materials, and techniques, predicts the future requirements, and subsequently discusses its avenues for improvement as a restorative modality. A literature search of the PubMed/Medline database was performed. Articles that discussed the history, types, materials, fabrication techniques, clinical implications, and future expectations related to maxillofacial prostheses and reconstruction were included. Fifty-nine articles were included in this review. Maxillofacial prostheses were classified as restorative or complementary with subclassifications based on the prostheses finality. The origin of maxillofacial prostheses is unclear; however, fabrication techniques and materials have undergone several changes throughout history. Currently, silicones and acrylic resins are the most commonly used materials to fabricate customized prostheses. Maxillofacial prostheses not only restore several types of orofacial defects but also improve the patients' quality of life. Although the current clinical scenario concerning the field of maxillofacial prostheses is promising, improvements in material quality and techniques for maxillofacial prostheses may be expected in the future, to produce better results in the treatment of patients.
Defining cognitive profiles of depressive patients using the Brief Assessment of Cognition in Affective Disorders

Background Cognitive impairments in patients with depressive disorders have a negative impact on their daily skill functioning and quality of life. In this study, we evaluated the cognitive profiles and associated factors of patients with depressive disorders with the Brief Assessment of Cognition in Affective Disorders (BAC-A). Methods This cross-sectional study consisted of 75 patients with depressive disorders (56 patients with major depressive disorder (MDD) and 19 patients with depressive disorder NOS or dysthymic disorder (non-MDD)). We evaluated the participants’ cognitive functions at euthymic status using the BAC-A. The BAC-A includes six subtests derived from the Brief Assessment of Cognition in Schizophrenia (BAC-S) and Affective Processing Tests. The current severity of depressive symptoms was assessed with the 17-item Hamilton Depression Rating Scale (HAMD-17), and we recorded any psychotropic drugs being used by the patients. Results We observed no differences in cognitive profiles in the MDD group and non-MDD group after adjusting for educational levels, severity of depression, and psychotropic drugs. Instead, the HAMD-17 scores were negatively correlated to cognitive performance in working memory, motor speed, verbal fluency, attention and processing speed, executive function, composite score, and the six indexes of the Affective Processing Test measured by the BAC-A. A longer illness duration was associated with worse performance of four indexes of the Affective Processing Test. Furthermore, benzodiazepine use was associated with a worse performance of verbal memory, and antidepressant use was associated with better motor speed performance. Conclusion The current severity of depressive symptoms and psychotropic drugs being taken, not the diagnosis category, are associated with cognitive impairments in patients with depressive disorders. Clinicians should pay particular attention to managing residual depressive symptoms and prescribing adequate psychotropic drugs in order to eliminate depressive patients’ cognitive deficits.
Assessment and Management of Postoperative Pain among Nurses at a Resource-Constraint Teaching Hospital in Ghana

Background Postoperative pain remains one of the greatest concerns for patients following surgical procedures. Nurses play an essential role in postoperative pain assessment and management, especially within the first few days after surgery. Objective The study investigated how nurses in a resource-constraint hospital in Ghana assessed and managed postoperative pain. Methods This was an explorative qualitative study involving 12 registered nurses practising in the largest referral hospital in Ghana. Data was gathered using a semistructured interview guide. Demographic characteristics of participants were summarized using descriptive statistics. Data were analysed using Kvale's three phases for analysing qualitative data. First, the entire text was read again to identify meaning units which were then condensed. Second, the condensed texts were read again and interpreted. Finally, the condensed data containing similar meaning were coded and then sorted into subthemes. Results It was found that some nurses have never used any pain assessment tool due to lack of standard tool for assessing postoperative pain. The majority of nurses reported that managing pain by using medication was the norm especially in the first 24 hours after surgery. Conclusion Although participants may have some knowledge of assessing and managing postoperative pain, this knowledge was not largely used to manage postoperative pain effectively, partly because of resource constraints. Therefore, there is the need for adequate training and with provision of resources, it is imperative that the use of standardized pain assessment scales could help in the proper assessment and management of postoperative pain in this setting.
Image Forensics Based on Lighting Estimation

Computer generated images are assumed to be a key part in each person’s life in this era of information technology, where individuals effectively inhabit the advertisements, magazines, websites, televisions and many more. At the point when digital images played their role, the event of violations in terms of misrepresentation of information, use of their wrong doings winds up and also becomes easier with the help of image editing application programs. To be legitimate, if anyone does wrong anything then the proposed method can be used for a correct identification of the forgery and the imitations in the digital images. In existing techniques, researchers have suggested most well-known types of digital photographic manipulations based on source, meta-data, image copying, splicing and many more. The proposed approach is inspired by physics-based techniques and requires less human involvement. The presented approach works for images having any type of objects present in the scene, i.e. not only limited to human faces and selection of same intensity regions of the image. By assessing the lighting parameters, the proposed technique identifies the manipulated object and returns angle of incidence w.r. t light source direction. The demonstrated result produces forgery recognition rate of 92% on an image dataset comprising of various types of manipulated images.
Interactive Pattern Analysis of Multiple T-Maze Data

The Multiple T-Maze study is one of the standard methods used in ethology and behaviourism. In this paper we extend the current state of the art in analysis of Multiple T-Maze data for animal cohorts. We focus on pattern ﬁnding within animals’ paths. We introduce the Sequence View which makes it possible to quickly spot patterns and to search for speciﬁc sub-paths in animal paths. Further, we also evaluate four different metrics for string comparison and two widely used embeddings to support interactive clustering. All views are fully integrated in a coordinated multiple views system and support active brushing. This research represents a step towards (semi)-automatic clustering for Multiple T-Maze cohort data, which will signiﬁcantly improve the Multiple T-Maze data analysis.
Wide BVH traversal with a short stack

Compressed wide bounding volume hierarchies can significantly improve the performance of incoherent ray traversal, through a smaller working set of inner nodes and therefore a higher cache hit rate. While inner nodes in the hierarchy can be compressed, the size of the working set for a full traversal stack remains a significant overhead. In this paper we introduce an algorithm for wide bounding volume hierarchy (BVH) traversal that uses a short stack of just a few entries. This stack can be fully stored in scarce on-chip memory, which is especially important for GPUs and dedicated ray tracing hardware implementations. Our approach in particular generalizes the restart trail algorithm for binary BVHs to BVHs of arbitrary widths. Applying our algorithm to wide BVHs, we demonstrate that the number of traversal steps with just five stack entries is close to that of a full traversal stack. We also propose an extension to efficiently cull leaf nodes when a closer intersection has been found, which reduces ray primitive intersections by up to 14%.
A Review of Enhancement and Segmentation Techniques for Digital Images

Image enhancement and segmentation are the two imperative steps while processing digital images. The goal of enhancement is to improve the quality of images so as to nullify the effect of poor illumination conditions during image acquisition. Afterwards, segmentation is performed to extract region of interest (ROI) from the background details of the image. There is a vast literature available for both the techniques. Therefore, this paper is intended to summarize the basic as well as advanced enhancement and segmentation techniques under a single heading; to provide an insight for future researches in the field of pattern recognition.
Human Influenza A Virus Hemagglutinin Glycan Evolution Follows a Temporal Pattern to a Glycan Limit

Frequent mutation of its major antibody target, the glycoprotein hemagglutinin, ensures that the influenza virus is perennially both a rapidly emerging virus and a major threat to public health. One type of mutation escapes immunity by adding a glycan onto an area of hemagglutinin that many antibodies recognize. This study revealed that these glycan changes follow a simple temporal pattern. Every 5 to 7 years, hemagglutinin adds a new glycan, up to a limit. After this limit is reached, no net additions of glycans occur. Instead, glycans are swapped or lost at longer intervals. Eventually, a pandemic replaces the terminally glycosylated hemagglutinin with a minimally glycosylated one from the animal reservoir, restarting the cycle. This pattern suggests the following: (i) some hemagglutinins are evolved for this decades-long process, which is both defined by and limited by successive glycan addition; and (ii) hemagglutinin's antibody dominance and its capacity for mutations are highly adapted features that allow influenza to outpace our antibody-based immunity. ABSTRACT Human antibody-based immunity to influenza A virus is limited by antigenic drift resulting from amino acid substitutions in the hemagglutinin (HA) head domain. Glycan addition can cause large antigenic changes but is limited by fitness costs to viral replication. Here, we report that glycans are added to H1 and H3 HAs at discrete 5-to-7-year intervals, until they reach a functional glycan limit, after which glycans are swapped at approximately 2-fold-longer intervals. Consistent with this pattern, 2009 pandemic H1N1 added a glycan at residue N162 over the 2015–2016 season, an addition that required two epistatic HA head mutations for complete glycosylation. These strains rapidly replaced H1N1 strains globally, by 2017 dominating H3N2 and influenza B virus strains for the season. The pattern of glycan modulation that we outline should aid efforts for tracing the epidemic potential of evolving human IAV strains. IMPORTANCE Frequent mutation of its major antibody target, the glycoprotein hemagglutinin, ensures that the influenza virus is perennially both a rapidly emerging virus and a major threat to public health. One type of mutation escapes immunity by adding a glycan onto an area of hemagglutinin that many antibodies recognize. This study revealed that these glycan changes follow a simple temporal pattern. Every 5 to 7 years, hemagglutinin adds a new glycan, up to a limit. After this limit is reached, no net additions of glycans occur. Instead, glycans are swapped or lost at longer intervals. Eventually, a pandemic replaces the terminally glycosylated hemagglutinin with a minimally glycosylated one from the animal reservoir, restarting the cycle. This pattern suggests the following: (i) some hemagglutinins are evolved for this decades-long process, which is both defined by and limited by successive glycan addition; and (ii) hemagglutinin's antibody dominance and its capacity for mutations are highly adapted features that allow influenza to outpace our antibody-based immunity.