Miracle-dz/UniFAR-FTUs huggingface dataset:
Association of elevated levels of cellular lipoteichoic acids of group B streptococci with human neonatal disease

Cell-associated lipoteichoic acids (LTAs) from late-exponential-phase cultures (serotypes Ia, Ib, Ic, II, and III) of group B streptococci isolated from infected and asymptomatically colonized infants were quantitated and characterized by growing the organisms in a chemically defined medium containing [3H]glycerol and [14C]acetate. Cell pellets were extracted with 45% aqueous phenol and chloroform-methanol and subjected to DEAE-Sephacel anion-exchange chromatography. Elution profiles resolved three major peaks, I, II, and III, with glycerol and phosphate present in a 1:1 molar ratio in each peak, and results obtained by Ouchterlony immunodiffusion analysis confirmed the presence of poly(glycerol phosphate). Saponification indicated that [14C]acetate was incorporated into fatty acids of peaks I and II only, suggesting that these were cell-associated LTAs. Peak II was of small molecular weight (less than 10,000) and probably represented another species of LTA. Peaks I and II were further demonstrated to be LTA by their ability to sensitize human type O erythrocytes. Peak III lacked fatty acids and was shown to probably be deacylated LTA. Quantitation of cell-associated teichoic acid material produced by the group B streptococcal strains indicated that the clinical isolates from infants with early- or late-onset disease possessed significantly higher levels than did the asymptomatic (clinical isolates from infants without symptoms of disease) group B streptococcal strains.
Palmnet: A Pension Asset and Liability Model for the Netherlands

This study presents a pension model geared to the typical pension contract in the Netherlands. It is based on a defined benefit/average earnings pension system. Nominal benefits are guaranteed and indexation is intended. The model provides a framework for analysing adjustments to such factors as the asset mix, retirement age, returns and the method of discounting, premium setting and indexation. The importance of uncertainty over interest rate movements and returns on shares is made explicit by means of stochastic and historical simulations. In this, PALMNET differs from existing, often deterministic pension models. The main findings are, first, a wage -indexed defined benefit pension is still affordable despite the current shortfall of wealth of pension funds. Second, fair value accounting considerably increases the volatility of pension premiums. Third, reducing risks by adjusting the asset mix towards more bonds is costly in terms of average premiums, but reduces the volatility. These conclusions are based on realistic to conservative assumptions regarding returns and risks.
Sequential learning for multimodal 3D human activity recognition with Long-Short Term Memory

Capability of recognizing human activities is essential to human robot interaction for an intelligent robot. Traditional methods generally rely on hand-crafted features, which is not strong and accurate enough. In this paper, we present a feature self-learning mechanism for human activity recognition by using three-layer Long Short Term Memory (LSTM) to model long-term contextual information of temporal skeleton sequences for human activities which are represented by the trajectories of skeleton joints. Moreover, we add dropout mechanism and L2 regularization to the output of the three-layer Long Short Term Memory (LSTM) to avoid overfitting, and obtain better representation for feature modeling. Experimental results on a publicly available UTD multimodal human activity dataset demonstrate the effectiveness of the proposed recognition method.
Optimizing the precision in T1 relaxation estimation using limited flip angles

In this article we describe the precision in the estimation of the spin–lattice relaxation time TI from MRI signals acquired for various flip angles with the repetition time TR held constant. We review the estimation procedure itself and present a model for the propagation of noise in the signal into the calculated TI. This model is verified by both Monte Carlo simulations and experimental data taken on image phantoms. Based on this model, we find that for a given TR/TI there exist two optimal flip angles that will minimize the uncertainty in the estimated TI. We also show how two optimal angles can be selected for a given range of TR/TI values. In addition, T1 estimation using the two optimal angles can be comparable to or better than using multiple evenly spaced angles. Finally, in an initial comparison with the two‐point saturation recovery method of calculating T1, results for equal total scanning time TRTot suggest that for T1 > 0.5 TRTot, the limited flip angle approach gives better TI precision whereas for TI < 0.5 TRTot, the saturation recovery approach is better. © Academic Press, Inc.
Morphine-6&bgr;-glucuronide Rapidly Increases Pain Sensitivity Independently of Opioid Receptor Activity in Mice and Humans

Background:Previous data indicate that morphine-6&bgr;-glucuronide (M6G), a morphine metabolite with analgesic properties, can paradoxically increase pain sensitivity in mice and humans. The authors tested mice and humans for M6G hyperalgesia and assessed the contribution of N-methyl-d-aspartate receptor activity in mice. Methods:Nociception after acute injection (10 mg/kg) and chronic infusion (1.6 mg/kg per 24 h) of M6G or saline was assayed using the tail-withdrawal test in CD-1 mice implanted with pellets containing the opioid antagonist naltrexone or placebo and in knockout mice lacking &mgr;-, &kgr;-, and &dgr;-opioid receptors and their B6129F1 controls. In volunteers, responses to heat pain were tested after a M6G (0.4 mg/kg) injection in the presence of a continuous high naloxone (0.04-mg/kg bolus followed by 0.04 mg/kg per hour) or saline background infusion. Results:Acute M6G injection evoked analgesia in CD-1 mice implanted with placebo pellets and B6129F1 control mice, whereas it caused hyperalgesia in CD-1 mice treated concurrently with naltrexone and in knockout mice. Continuous M6G infusion produced hyperalgesia within 24 h, lasting for a minimum of 6 days, in both placebo- and naltrexone-pelleted mice. The N-methyl-d-aspartate receptor antagonist MK-801 (0.05 mg/kg) blocked and reversed hyperalgesia after the acute injection and continuous infusion of M6G, respectively. In humans, M6G increased heat pain sensitivity for at least 6 h independently of simultaneous naloxone infusion. Conclusions:These data indicate that M6G causes hyperalgesia independent of previous or concurrent opioid receptor activity or analgesia. In mice, a causal role for the N-methyl-d-aspartate receptor is also indicated.
Pain and emotional well-being outcomes in Southwest Oncology Group-directed intergroup trial S0205: a phase III study comparing gemcitabine plus cetuximab versus gemcitabine as first-line therapy in patients with advanced pancreas cancer.

PURPOSE S0205 was a randomized clinical trial that compared the therapeutic impact of gemcitabine versus gemcitabine plus cetuximab. Study results for patient-reported health-related quality of life (HRQL) outcomes are reported. PATIENTS AND METHODS Patients completed the Brief Pain Inventory and a measure of emotional well-being (each measured on a 0 to 10 scale) at baseline and at weeks 5, 9, 13, and 17 postrandom assignment. Worst pain status was classified as palliated (worst pain scores < 5 maintained for 2 consecutive cycles) or not palliated (remaining patients) and tested with a chi(2) test. Change in emotional well-being and worst pain (exploratory analysis) were assessed over 17 weeks using generalized estimating equations with inverse probability of censoring weights. RESULTS Seven hundred twenty of 766 enrolled patients contributed baseline HRQL data. The two treatment arms did not differ statistically in the percentage of patients with successful worst pain palliation. Longitudinal analyses showed significantly improved emotional well-being for patients on both arms by weeks 13 and 17 (P < .01 and P < .001). An exploratory longitudinal analysis of worst pain showed significant decreases at all time points for both arms (P < .01 and P < .001). Significant treatment arm differences for either worst pain or emotional well-being were not observed at any of the assessment times. CONCLUSION We observed palliated pain and improved well-being for patients on this trial. However, these improvements were similar in both treatment arms, suggesting that the addition of cetuximab did not contribute to improvement in these HRQL outcomes.
Scaling strength and power for body mass differences in rugby union players.

AIM This study on professional rugby union players was undertaken to: 1) confirm a relationship between body mass (BM) and peak force (PF) and peak power (PP); 2) evaluate the effect of ratio and allometric scaling on these relationships; and 3) compare the PF and PP abilities of different positional groups with each approach. METHODS Seventy-nine rugby players were assessed for PF during an isometric mid-thigh pull and/or countermovement jump PP. Athlete performance was normalized for BM using standard ratio and allometric scaling methods. The performance data from inside backs (IB), outside backs (OB), tight forwards (TF) and loose forwards (LF) were compared before and after scaling for BM. RESULTS Significant relationships were identified between BM and the absolute expression of PF (r=0.25) and PP (r=0.44). These relationships improved with the application of ratio scaling (r=-0.53 to -0.57), but were eliminated after allometric scaling with the derived exponents (r=0.00-0.02). No positional group differences in absolute and allometrically scaled PF and PP were seen, but ratio scaled performance favoured the lighter IB and OB over the heavier TF and/or LF (P<0.05). CONCLUSION The PF and PP abilities of professional rugby union players were related to individual BM and these relationships were differentially affected by ratio (enhanced) and allometric (removed) scaling. Ratio scaled performance favoured the lighter backs over the heavier forwards, which could be explained by their specific movement patterns within a game. Comparing positional data in such a manner may help practitioners to better quantify, assess and monitor the position-specific needs of athletes in team sport.
Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).

A murine monoclonal antibody specific for calf intestinal alkaline phosphatase has been prepared and used in an unlabeled antibody bridge technique for labeling monoclonal antibodies. This procedure--the alkaline phosphatase monoclonal anti-alkaline phosphatase (APAAP) method--gives excellent immunocytochemical labeling of tissue sections and cell smears, comparable in clarity and intensity to that achieved with immunoperoxidase labeling. If the enzyme label is developed with a naphthol salt as a coupling agent and Fast Red or hexazotized new fuchsin as a capture agent, a vivid red reaction product is obtained which is very easily detected by the human eye. For this reason the APAAP technique was found particularly suitable for labeling cell smears (for both cytoplasmic and surface-membrane antigens) and for detecting low numbers of antigen-bearing cells in a specimen (e.g., carcinoma cells in a malignant effusion). It was found possible to enhance the intensity of the APAAP labeling reaction substantially by repeating the second and third incubation steps (i.e., the unlabelled "bridge" antibody and APAAP complexes). The APAAP technique was superior to immunoperoxidase labeling for staining tissues rich in endogenous peroxidase, and could be used in conjunction with immunoperoxidase methods for double immunoenzymatic staining. The method was also applicable to the detection of antigenic molecules following their electrophoretic transfer from SDS-polyacrylamide gels to nitrocellulose sheets ("immunoblotting").
The Redistributive Design of Social Security Systems

Countries with low intragenerational redistribution in social security systems (Bismarckian) are associated with larger public pension expenditures, a smaller fraction of private pension and lower income inequality than countries with more redistributive social security (Beveridgean). This paper introduces a bidimensional voting model to account for these features. Agents different in age, income and in their ability to invest in the capital market vote on the degree of redistribution of the social security system and on the size of the transfer. In an economy with three income groups, a small Beveridgean system is supported by low-income agents, who gain from its redistributive feature, and high-income individuals, who seek to minimize their tax contribution and to invest in a private scheme. Middle-income individuals instead favor a large Bismarckian system.
Detection of syntonies between multiple spike trains using a coarse-grain binarization of spike count distributions

At very short timescales neuronal spike trains may be compared to binary streams where each neuron gives at most one spike per bin and therefore its state can be described by a binary variable. Time-averaged activity like the mean firing rate can be generally used on longer timescales to describe the dynamics; nevertheless, enlarging the space of the possible states up to the continuum may seriously bias the true statistics if the sampling is not accurate. We propose a simple transformation on binary variables which allows us to fix the dimensionality of the space to sample and to vary the temporal resolution of the analysis. For each time length interactions among simultaneously recorded neurons are evaluated using log–linear models. We illustrate how to use this method by analysing two different sets of data, recorded respectively in the temporal cortex of freely moving rats and in the inferotemporal cortex of behaving monkeys engaged in a visual fixation task. A detailed study of the interactions is provided for both samples. In both datasets we find that some assemblies share robust interactions, invariant at different time lengths, while others cooperate only at delimited time resolutions, yet the size of the samples is too small to allow an unbiased estimate of all possible interactions. We conclude that an extensive application of our method to larger samples of data, together with the development of techniques to correct the bias in the estimate of the coefficients, would provide significant information about the structure of the interactions in populations of neurons.
Preventing depression and anxiety in young people: a review of the joint efficacy of universal, selective and indicated prevention

Depression and anxiety (internalizing disorders) are the largest contributors to the non-fatal health burden among young people. This is the first meta-analysis to examine the joint efficacy of universal, selective, and indicated preventive interventions upon both depression and anxiety among children and adolescents (5–18 years) while accounting for their co-morbidity. We conducted a systematic review of reviews in Medline, PsycINFO and the Cochrane Library of Systematic Reviews, from 1980 to August 2014. Multivariate meta-analysis examined the efficacy of preventive interventions on depression and anxiety outcomes separately, and the joint efficacy on both disorders combined. Meta-regressions examined heterogeneity of effect according to a range of study variables. Outcomes were relative risks (RR) for disorder, and standardized mean differences (Cohen's d) for symptoms. One hundred and forty-six randomized controlled trials (46 072 participants) evaluated universal (children with no identified risk, n = 54) selective (population subgroups of children who have an increased risk of developing internalizing disorders due to shared risk factors, n = 45) and indicated prevention (children with minimal but detectable symptoms of an internalizing disorder, n = 47), mostly using psychological-only strategies (n = 105). Reductions in internalizing disorder onset occurred up to 9 months post-intervention, whether universal [RR 0.47, 95% confidence interval (CI) 0.37–0.60], selective (RR 0.61, 95% CI 0.43–0.85) or indicated (RR 0.48, 95% CI 0.29–0.78). Reductions in internalizing symptoms occurred up to 12 months post-intervention for universal prevention; however, reductions only occurred in the shorter term for selective and indicated prevention. Universal, selective and indicated prevention interventions are efficacious in reducing internalizing disorders and symptoms in the short term. They might be considered as repeated exposures in school settings across childhood and adolescence. (PROSPERO registration: CRD42014013990.)
IgG Anti‐GM1 antibody is associated with reversible conduction failure and axonal degeneration in guillain‐barré syndrome

To investigate the pathophysiological role of anti‐GM1 antibody in Gullain‐Barre syndrome (GBS), we reviewed sequential nerve conduction studies of 345 nerves in 34 GBS patients. Statistically significant correlation between IgG anti‐GM1 antibodies and electrodiagnoses was found. Sixteen IgG anti‐GM1‐positive patients were classified as having acute motor sensory axonal neuropathy (AMAN or AMSAN) (12 patients), as having acute inflammatory demyelinating polyneuropathy (AIDP) (3 patientsrpar;, or as undetermined (1 patient) by electrodiagnostic criteria. Besides axonal features, there was rapid resolution of conduction slowing and block. In 3 patients initially diagnosed as having AIDP, conduction slowing was resolved within days, and 1 of them and 3 AMAN patients showed markedly rapid increases in amplitudes of distal compound muscle action potentials that were not accompanied by prolonged duration and polyphasia. The time courses of conduction abnormalities were distinct from those in IgG anti‐GM1‐negative AIDP patients. Rapid resolution of conduction slowing and block, and the absence of remyelinating slow components, suggest that conduction failure may be caused by impaired physiological conduction at the nodes of Ranvier. Reversible conduction failure as well as axonal degeneration constitutes the pathopsiological mechanisms in IgG anti‐GM1)positive GBS. In both cases, immune‐mediated attack probably occurs on the axolemma of motor fibers.
Cognitive bias modification procedures in the management of mental disorders

Purpose of review To review recent research on the therapeutic impact of cognitive bias modification (CBM) procedures, designed to train direct change in the patterns of attentional and interpretive bias known to characterize particular forms of psychopathology. Recent findings CBM designed to change attentional selectivity has proven capable of modifying attentional biases associated with emotional dysfunction, pain disorders, eating disorders and addictions. CBM designed to change interpretive selectivity has proven capable of modifying the tendency to resolve ambiguity in a negative manner that is characteristic of emotional dysfunction. Recent research confirms that both forms of CBM can alter the severity of symptoms associated with psychopathology. Extended delivery of such CBM approaches now has been shown to yield therapeutic benefits for a range of anxiety disorders, and in the case of CBM-A has augmented the efficacy of treatment for alcohol dependence. Summary CBM approaches have passed the proof-of-concept stage, and recent small-scale trials attest to their likely clinical value. There is a pressing need for large-scale randomized controlled trials, to compare the efficacy of CBM with that of alternative approaches, and to identify how CBM can most effectively be integrated into multimodal treatment programs.
Effect of Lactobacillus GG yoghurt in prevention of antibiotic associated diarrhoea.

The efficacy of Lactobacillus GG yoghurt in preventing erythromycin associated diarrhoea was studied. Sixteen healthy volunteers were given erythromycin acistrate 400 mg t.i. d for a week. The volunteers were randomly assigned into two groups taking twice daily 125 ml of either Lactobacillus GG fermented yoghurt or pasteurized regular yoghurt as placebo during the drug treatment. Subjects receiving Lactobacillus GG yoghurt with erythromycin had less diarrhoea than those taking pasteurized yoghurt. Other side effects of erythromycin, such as abdominal distress, stomach pain and flatulence, were less common in the GG yoghurt group than in the placebo yoghurt group. The subjects receiving Lactobacillus GG yoghurt were colonized with these bacteria even during erythromycin treatment as measured by faecal counts of total Lactobacillus GG. No Lactobacillus GG was found in the faecal samples of volunteers in the group taking pasteurized yoghurt.
Universal Modified Newtonian Dynamics Relation between the Baryonic and "Dynamical" Central Surface Densities of Disc Galaxies.

I derive a new modified Newtonian dynamics (MOND) relation for pure-disc galaxies: The "dynamical" central surface density, Σ_{D}^{0}, deduced from the measured velocities, is a universal function of only the true, "baryonic'' central surface density, Σ_{B}^{0}: Σ_{D}^{0}=Σ_{M}S(Σ_{B}^{0}/Σ_{M}), where Σ_{M}≡a_{0}/2πG is the MOND surface density constant. This surprising result is shown to hold in both existing, nonrelativistic MOND theories. S(y) is derived: S(y)=∫_{0}^{y}ν(y^{'})dy^{'}, with ν(y) being the interpolating function of the theory. The relation aymptotes to Σ_{D}^{0}=Σ_{B}^{0} for Σ_{B}^{0}≫Σ_{M}, and to Σ_{D}^{0}=(4Σ_{M}Σ_{B}^{0})^{1/2} for Σ_{B}^{0}≪Σ_{M}. This study was prompted by the recent finding of a correlation between related attributes of disc galaxies by Lelli et al. The MOND central-surface-densities relation agrees very well with these results.
Five-Year Follow-Up in Elastase-Induced Aneurysms in Rabbits

BACKGROUND AND PURPOSE: There is no report regarding patency of elastase-induced aneurysms for more than a 2-year period. Our aim was to report aneurysm patency rates up to 5 years in the elastase-induced aneurysm model in rabbits. MATERIALS AND METHODS: Twenty-five elastase-induced aneurysms were created in New Zealand white rabbits and followed for up to 5 years. Thirteen (52%) rabbits died during follow-up for reasons unrelated to the aneurysms. DSA was performed at 1 month and at 2 and 5 years in the 12 surviving subjects. Aneurysm patency and dimensions, including neck diameter and aneurysm width and height, were evaluated at each time point in relation to external sizing devices. Differences of aneurysm sizes (neck width and aneurysm width and height) among time points were compared by using the Student t test. RESULTS: Eleven (92%) of the 12 aneurysms in the subjects that survived for 5 years remained fully patent throughout follow-up. A single narrow-neck aneurysm showed partial thrombosis at the 2- and 5-year time points. CONCLUSIONS: Experimental elastase-induced aneurysms in rabbits demonstrate high rates of patency up to 5 years following creation. When planning for very long-term studies, investigators should plan for relatively high rates of mortality unrelated to aneurysm pathology.
On the All-Pairs-Shortest-Path Problem in Unweighted Undirected Graphs

We present an algorithm, APD, that solves the distance version of the all-pairs-shortest-path problem for undirected, unweighted n-vertex graphs in time O(M(n) log n), where M(n) denotes the time necessary to multiply two n x n matrices of small integers (which is currently known to be o(n 2.376 )). We also address the problem of actually finding a shortest path between each pair of vertices and present a randomized algorithm that matches APD in its simplicity and in its expected running time.