Miracle-dz/UniFAR-FTUs huggingface dataset:
Sur un problème de stabilité posé en optique géométrique non linéaire surcritique

Cet exposé s’intéresse à un modèle réaliste issu de la mécanique des fluides. L’objectif est de montrer qu’il est possible de traiter dans un tel cadre des problèmes d’instabilité soulevés par la propagation de singularités qualifiées de surcritiques. D’abord, nous introduisons le modèle (équations de type Navier-Stokes) et ses motivations (questions liées à la propagation d’oscillations en régime turbulent). Ensuite, nous présentons deux résultats (relatifs au caractère bien posé d’un problème de Cauchy oscillant) dont nous expliquons les difficultés sous-jacentes (dues à l’absence de contrôles suffisants via les estimations d’énergie classiques). Dans un troisième volet, nous décrivons la stratégie suivie pour prouver les deux énoncés donnés. Enfin, nous indiquons quelques applications possibles de la méthode.
Association Between Depression, Anxiety, and Antidepressant Use With T-Wave Amplitude and QT-Interval

Objectives: Cardiac repolarization may be affected by psychiatric disorders and/or antidepressant use, but evidence for this is inconclusive. This study examined the relationship between depressive and anxiety disorder and use of antidepressants with T-wave amplitude (TWA) and QT-interval. Methods: Data was obtained from the Netherlands Study of Depression and Anxiety (n = 1,383). Depression/anxiety was diagnosed with the DSM-IV based Composite International Diagnostic Interview. The use of tricyclic antidepressants (TCAs), selective serotonin and noradrenalin reuptake inhibitors (SNRIs), and selective serotonin reuptake inhibitors (SSRIs) was established. T-wave amplitude and QT-interval corrected for heart rate (QTc) were obtained from an ECG measured in a type II axis configuration. Results: Compared to controls, persons with depression or anxiety disorders did not show a significantly different TWA (p = 0.58; Cohen's d = 0.046) or QTc (p = 0.48; Cohen's d = −0.057). In spite of known sympathomimetic effects, TCA use (p = 0.26; Cohen's d = −0.162) and SNRI use (p = 0.70; Cohen's d = −0.055) were not significantly associated with a lower TWA. TCA use (p = 0.12; Cohen's d = 0.225) and SNRI use (p = 0.11; Cohen's d = 0.227) were also not significantly associated with a prolonged QTc. Conclusion: We did not find evidence that either depressive/anxiety disorder or antidepressant use is associated with abnormalities in TWA or QTc. Earlier found sympathomimetic effects of TCAs and SNRIs are not evident in these measures of cardiac repolarization.
Optical fiber force myography sensor for applications in prosthetic hand control

The application of an optical fiber sensor on the identification of hand postures by force myography technique is reported. The transducers are comprised of fiber microbending elements attached to the user forearm, allowing the assessment of muscular activities related to the hand movements. Next, the output light intensities are detected, and then correlated to the performed postures by means of artificial neural networks. The methodology was applied on the identification of 5 postures, yielding a 96.7% accuracy considering the average of 4 subjects. Finally, the sensor was utilized for controlling a virtual prosthetic hand implemented on V-REP environment, based on the event driven finite-state approach, providing the real-time execution of predefined grasp patterns.
Inhibition of miR-141-3p Ameliorates the Negative Effects of Poststroke Social Isolation in Aged Mice

Background and Purpose— Social isolation increases mortality and impairs recovery after stroke in clinical populations. These detrimental effects have been recapitulated in animal models, although the exact mechanism mediating these effects remains unclear. Dysregulation of microRNAs (miRNAs) occurs in both strokes as well as after social isolation, which trigger changes in many downstream genes. We hypothesized that miRNA regulation is involved in the detrimental effects of poststroke social isolation in aged animals. Methods— We pair-housed 18-month-old C57BL/6 male mice for 2 weeks before a 60-minute right middle cerebral artery occlusion or sham surgery and then randomly assigned mice to isolation or continued pair housing immediately after surgery. We euthanized mice either at 3, 7, or 15 days after surgery and isolated the perilesional frontal cortex for whole microRNAome analysis. In an additional cohort, we treated mice 1 day after stroke onset with an in vivo-ready antagomiR-141 for 3 days. Results— Using whole microRNAome analysis of 752 miRNAs, we identified miR-141-3p as a unique miRNA that was significantly upregulated in isolated mice in a time-dependent manner up to 2 weeks after stroke. Posttreatment with an antagomiR-141-3p reduced the postisolation-induced increase in miR-141-3p to levels almost equal to those of pair-housed stroke controls. This treatment significantly reduced mortality (by 21%) and normalized infarct volume and neurological scores in poststroke-isolated mice. Quantitative PCR analysis revealed a significant upregulation of Tgf&bgr;r1 (transforming growth factor beta receptor 1, a direct target of miR-141-3p) and Igf-1 (insulin-like growth factor 1) mRNA after treatment with antagomiR. Treatment also increased the expression of other pleiotropic cytokines such as Il-6 (interleukin 6) and Tnf-&agr; (tumor necrosis factor-&agr;), an indirect or secondary target) in brain tissue. Conclusions— miR-141-3p is increased with poststroke isolation. Inhibition of miR-141-3p improved mortality, neurological deficits, and decreased infarct volumes. Importantly, these therapeutic effects occurred in aged animals, the population most at risk for stroke and poststroke isolation.
Engaging myosin VI tunes motility, morphology and identity in endocytosis

While unconventional myosins interact with different stages of the endocytic pathway, they are ascribed a transport function that is secondary to the protein complexes that control organelle identity. Endosomes are subject to a dynamic, continuous flux of proteins that control their characteristic properties, including their motility within the cell. Efforts to describe the changes in identity of this compartment have largely focused on the adaptors present on the compartment and not on the motile properties of the compartment itself. In this study, we use a combination of optogenetic and chemical‐dimerization strategies to target exogenous myosin VI to early endosomes, and probe its influence on organelle motility, morphology and identity. Our analysis across timescales suggests a model wherein the artificial engagement of myosin VI motility on early endosomes restricts microtubule‐based motion, followed by morphological changes characterized by the rapid condensation and disintegration of organelles, ultimately leading to the enhanced overlap of markers that demarcate endosomal compartments. Together, our findings show that synthetic engagement of myosin VI motility is sufficient to alter organelle homeostasis in the endocytic pathway.
A graph-based framework for analyzing SQL query logs

Analytical SQL queries are a valuable source of information. Query log analysis can provide insight into the usage of datasets and uncover knowledge that cannot be inferred from source schemas or content alone. To unlock this potential, flexible mechanisms for meta-querying are required. Syntactic and semantic aspects of queries must be considered along with contextual information. We present an extensible framework for analyzing SQL query logs. Query logs are mapped to a multi-relational graph model and queried using domain-specific traversal expressions. To enable concise and expressive meta-querying, semantic analyses are conducted on normalized relational algebra trees with accompanying schema lineage graphs. Syntactic analyses can be conducted on corresponding query texts and abstract syntax trees. Additional metadata allows to inspect the temporal and social context of each query. In this demonstration, we show how query log analysis with our framework can support data source discovery and facilitate collaborative data science. The audience can explore an exemplary query log to locate queries relevant to a data analysis scenario, conduct graph analyses on the log and assemble a customized logmonitoring dashboard.
Patient experiences with high-risk oral lesions from detection to diagnosis

ii PREFACE . iv TABLE OF CONTENTS . vi LIST OF TABLES . x LIST OF FIGURES . xi LIST OF ABBREVIATIONS . xii LIST OF SYMBOLS . xiv ACKNOWLEDGEMENTS . xvi DEDICATION. xx
Cytomegalovirus: Shape-Shifting the Immune System

Systems-based based approaches have begun to shed light on extrinsic factors that contribute to immune system variation. Among these, CMV (HHV-5, a β-herpesvirus) imposes a surprisingly profound impact. Most of the world’s population is CMV+, and the virus goes through three distinct infection phases en route to establishing lifelong détente with its host. Immune control of CMV in each phase recruits unique arms of host defense, and in turn the virus employs multiple immune-modulatory strategies that help facilitate the establishment of lifelong persistence. In this review, we explain how CMV shapes immunity and discuss the impact it may have on overall health.
Dose-response associations of methicillin-resistant Staphylococcus aureus between school environmental contamination and nasal carriage by elementary students

Background Methicillin-resistant Staphylococcus aureus (MRSA) can cause serious infections in elementary students. Therefore, we aimed to elucidate the quantitative associations of school environmental contamination with nasal carriage of MRSA by students in a dose-response manner. Phenotypic and molecular characterizations were performed to further assess the associations. Materials and methods A cross-sectional study was conducted from March to August 2016 in eight elementary schools in Guangzhou, China. A multistage stratified cluster sampling design was used to include Chinese students and selected classes. Nasal swabs from students and environmental swabs from the schools were collected. The dose-response relationship was examined using multivariate logistic regression modeling with cluster-correlated robust variance estimates to account for correlations of isolates between the environment and the students. Results The prevalence rates of MRSA among 1705 students and 1240 environment samples were 10.15% and 3.87%, respectively. There were positive prevalence associations of school (odds ratio 1.09, 95% confidence interval [CI] 1.05–1.13) and class (odds ratio 1.03, 95% CI 1.01–1.06) environmental contamination with nasal carriage of MRSA isolates by students. Conclusions Comparisons of MRSA isolates between the environment and the students in terms of phenotypic and molecular characterization were mostly insignificant. School environmental contamination with MRSA was positively associated with MRSA nasal carriage by elementary students. Disinfection measures and education regarding hand hygiene should be considered to decrease the prevalence of MRSA nasal carriage among students.
Suf fi cient levels of 25-hydroxyvitamin D and protein intake required to increase muscle mass in sarcopenic older adults e The PROVIDE study

a Nutricia Research, Nutricia Advanced Medical Nutrition, Utrecht, The Netherlands b Department of Internal Medicine, Section of Gerontology and Geriatrics, VU University Medical Center, Amsterdam, The Netherlands c Department of Human Movement Sciences, MOVE Research Institute Amsterdam, VU University, Amsterdam, The Netherlands d Department of Medicine and Aged Care, Royal Melbourne Hospital, University of Melbourne, Australia e Department of Geriatric Medicine, Carl von Ossietzky University, Oldenburg, Germany f Frailty in Ageing Research Group (FRIA), Vrije Universiteit Brussel (VUB), Brussels, Belgium g Human Nutrition Research Centre, School of Agriculture, Food and Rural Development, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, United Kingdom h Department of Experimental Medicine, Section of Medical Pathophysiology, Endocrinology and Human Nutrition, “Sapienza” University of Rome, Italy i Department of Clinical and Experimental Medicine, Section of Geriatrics, University of Parma, Italy j Ageing and Health, Ninewells Hospital and Medical School, University of Dundee, United Kingdom k Friedrich-Alexander-Universit€ at Erlangen-Nürnberg, Germany l CHU Clermont-Ferrand, Service de Nutrition Clinique, F-63003 Clermont-Ferrand, France m Clermont Universit e, Universit e d'Auvergne, Unit e de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France n Department of Public Health and Caring Sciences/Clinical Nutrition and Metabolism, Department of Geriatric Medicine, Uppsala University Hospital, Sweden
Towards a Model-Free Estimate of the Limits to Student Modeling Accuracy

This paper attempts to quantify the accuracy limit of “nextitem-correct” prediction by using numerical optimization to estimate the student’s probability of getting each question correct given a complete sequence of item responses. This optimization is performed without an explicit parameterized model of student behavior, but with the constraint that a student’s likelihood of getting a problem correct only increases or remains unchanged with additional practice (i.e., no forgetting). We present results for this method for the Assistments 2009–2010 data where it suggests that there is only modest opportunity for improvement beyond the state of the art predictors. Furthermore, we describe a framework for applying this method to datasets where problems can be tagged with multiple skills and problem difficulties. Lastly, we discuss the limitations of this method, specifically its inability to give tight bounds on short sequences.
Low-Cytotoxicity Fluorescent Probes Based on Anthracene Derivatives for Hydrogen Sulfide Detection

Owing to the role of H2S in various biochemical processes and diseases, its accurate detection is a major research goal. Three artificial fluorescent probes based on 9-anthracenecarboxaldehyde derivatives were designed and synthesized. Their anion binding capacity was assessed by UV-Vis titration, fluorescence spectroscopy, HRMS, 1HNMR titration, and theoretical investigations. Although the anion-binding ability of compound 1 was insignificant, two compounds 2 and 3, containing benzene rings, were highly sensitive fluorescent probes for HS− among the various anions studied (HS−, F−, Cl−, Br−, I−, AcO−, H2PO4-, SO32-, Cys, GSH, and Hcy). This may be explained by the nucleophilic reaction between HS− and the electron-poor C=C double bond. Due to the presence of a nitro group, compound 3, with a nitrobenzene ring, showed stronger anion binding ability than that of compound 2. In addition, compound 1 had a proliferative effect on cells, and compounds 2 and 3 showed low cytotoxicity against MCF-7 cells in the concentration range of 0–150 μg·mL−1. Thus, compounds 2 and 3 can be used as biosensors for the detection of H2S in vivo and may be valuable for future applications.
Intuitive visualization technique to support eye tracking data analysis: a user-study

While fixation distribution is conventionally visualized using heat maps, there is still a lack of a commonly accepted technique to visualize saccade distributions. Inspired by wind maps and the Oriented Line Integral Convolution (OLIC) technique, we visualize saccades by drawing ink droplets which follow the direction indicated by a flow direction map. This direction map is computed using a kernel density estimation technique over the tangent directions to each saccade gaze point. The image is further blended with the corresponding heat map. It results in an animation or a static image showing main directions of the transitions between different areas of interest. We also present results from a web-based user study where naive non-expert users where asked to identify the direction of the flow and simple patterns. The results showed that these visualizations can successfully be used to support visual analysis of the eye-tracking data. It also showed that the use of animation allows to ease the task and to improve the performance.
Stages of oocyte development in the zebrafish, Brachydanio rerio

Oocyte development has been divided into five stages in the zebrafish Brachydanio rerio, based on morphological criteria and on physiological and biochemical events. In stage I (primary growth stage), oocytes reside in nests with other oocytes (Stage IA) and then within a definitive follicle (Stage IB), where they greatly increase in size. In stage II (cortical alveolus stage), oocytes are distinguished by the appearance of variably sized cortical alveoli and the vitelline envelope becomes prominent. In stage III (vitellogenesis), yolk proteins appear in oocytes and yolk bodies with crystalline yolk accrue during this major growth stage. Ooctes develop the capacity to respond in vitro to the steroid 17α, 20β‐dihydroxy‐4‐pregnen‐3‐one (DHP) by undergoing oocyte maturation. In stage IV (oocyte maturation), oocytes increase slightly in size, become translucent, and their yolk becomes non‐crystalline as they undergo final meiotic maturation in vivo (and in response to DHP in vitro). In stage V (mature egg), eggs (approx. 0.75 mm) are ovulated into the ovarian lumen and are capable of fertilization. This staging series lays the foundation for future studies on the cellular processes occurring during oocyte development in zebrafish and should be useful for experimentation that requires an understanding of stage‐specific events. © 1993 Wiley‐Liss, Inc.
Anthropometric measures of central adiposity are highly concordant with predictors of cardiovascular disease risk in HIV patients.

Background Body fat redistribution and metabolic abnormalities found in HIV patients receiving highly active antiretroviral therapy (HAART) contribute to an atherogenic profile, increasing cardiovascular disease risk. Objective We aimed to evaluate adiposity measures/indexes and propose cutoffs associated with predictors of cardiovascular disease risk in HIV patients on HAART. Design To evaluate cardiovascular disease risk in this cross-sectional study, we conducted electrocardiogram exams and stress electrocardiography, measured the ankle brachial index and blood pressure arterial hypertension, conducted lipid biochemical tests, and measured blood glucose. We measured circumferences [waist (WC), hip, thigh, calf, neck, trunk] and skinfold thicknesses (biceps, triceps, subscapular, suprailiac), conducted bioelectrical impedance analysis (BIA), and calculated indexes [body mass index, waist-to-hip ratio, waist-to-thigh ratio, waist-to-calf ratio, waist-to-height ratio (WHtR), trunk-to-arm ratio, body mass index corrected for body fat mass, Body Adiposity Index, conicity index, body shape index, fat mass (percentage), and phase angle]. For evaluating the performance of all adiposity measures/indexes, we used receiver operating characteristic (ROC) curves. Results Measures of central adiposity WC and WHtR showed the best performances-WC area under the curve (AUC) for men: 0.83 (95% CI: 0.78, 0.89; P < 0.05); WC AUC for women: 0.86 (95% CI: 0.81, 0.91; P < 0.05); WHtR AUC for men: 0.83 (95% CI: 0.78, 0.88; P < 0.05); and WHtR AUC for women: 0.85 (95% CI: 0.80, 0.91; P < 0.05). All adiposity measures/indexes presented different cutoffs from those proposed for the HIV seronegative population. The cutoffs for WC were 87.75 cm (sensitivity: 82.2%; specificity: 75.5%) for men and 90.5 cm (sensitivity: 84.0%; specificity: 73.0%) for women. Conclusions The measures/indexes of central adiposity presented excellent associations with predictors of cardiovascular disease risk, and the use of the cutoffs proposed in the present study aims to contribute to the early identification of increasing risk of cardiovascular diseases, enabling interventions. This trial was registered at the Brazilian clinical trials registry Registro brasileiro de ensaios clínicos (Rebec) as RBR-9rcxbq.
Adaptive Consensus-Based Robust Strategy for Economic Dispatch of Smart Grids Subject to Communication Uncertainties

The economic dispatch problem is investigated in this paper for a class of smart grids subject to unknown communication uncertainties. Compared with existing works related to economic dispatch where the dispatch algorithms are carried out by a centralized controller, a new kind of distributed dispatch algorithms are developed to achieve optimal dispatch of electric power by appropriately sharing the load among different generating units while guaranteeing consensus among incremental costs. An adaptive weight-adjustment technique is suggested that enables the dispatch algorithms to choose the communication weights among neighboring generating units which yield consensus of incremental costs under both cases with or without capacity limitations. The achievement of such a consensus leads to optimal dispatch of electronic power and secures the system performance against unknown communication uncertainties. Meanwhile, it is proved that the power demand and supply of the considered smart grids will be kept in a balanced state during the dispatch process. The interesting issue of how to assign the power outputs among generating units to balance the power demand and supply of the considered smart grids is also addressed. Finally, the numerical results of several case studies have been provided to verify the effectiveness of the proposed algorithms.
Histological examination of flight muscle development and breakdown in Bemisia tabaci (Homoptera: Aleyrodidae): Relationship to age and flight behvior

Bemisia tabaci exhibited their longest flights between 3 and 5 days following adult eclosion. They rarely engaged in flight when they were < 4 hr old and were only capable of short‐duration flights after day 7. This difference in flight capacity appears to be associated with changes in the flight musculature and mitochondria. Myofibrils and mitochondria accounted for approximately 50% and 33% of the area within the flight muscles, respectively. These two elements, however, varied with the age and sex of the whitefly. The percentage of the total area occupied by myofibrils was lower in 9‐day‐old males relative to females and all other age categories. Sarcomere length decreased in older whiteflies, regardless of the sex. Myofibril diameter did not vary with the age of the whitefly, but the diameter of female whitefly myofibrils was greater than the diameter of male whitefly myofibrils. The number of myosin filaments within a myofibril unit increased with age, peaking at 5 days of age for females and 7 days of age for males. In all age groups, females had more myosin filaments than were found in males.
GPU-Accelerated High-Throughput Online Stream Data Processing

The Single Instruction Multiple Data (SIMD) architecture of Graphic Processing Units (GPUs) makes them perfect for parallel processing of big data. In this paper, we present the design, implementation and evaluation of G-Storm, a GPU-enabled parallel system based on Storm, which harnesses the massively parallel computing power of GPUs for high-throughput online stream data processing. G-Storm has the following desirable features: 1) G-Storm is designed to be a general data processing platform as Storm, which can handle various applications and data types. 2) G-Storm exposes GPUs to Storm applications while preserving its easy-to-use programming model. 3) G-Storm achieves high-throughput and low-overhead data processing with GPUs. 4) G-Storm accelerates data processing further by enabling Direct Data Transfer (DDT), between two executors that process data at a common GPU. We implemented G-Storm based on Storm 0.9. 2 and tested it using three different applications, including continuous query, matrix multiplication and image resizing. Extensive experimental results show that 1) Compared to Storm, G-Storm achieves over 7× improvement on throughput for continuous query, while maintaining reasonable average tuple processing time. It also leads to 2.3× and 1.3× throughput improvements on the other two applications, respectively. 2) DDT significantly reduces data processing time.