Miracle-dz/UniFAR-FTUs huggingface dataset:
An investigation of the performances of simple gene selection methodologies for cancer classification

Gene expression datasets usually contain a large number of genes which impose a computational burden and complexity on the classifier. Thus, feature selection plays an integral part in sophisticated cancer classification frameworks. In the existing literature, feature selections have been often performed by computationally expensive methods (e.g., wrapper-based methods, evolutionary algorithms). In this paper, we show that the combinations of various simple feature selection methods that require minimal computational cost are often effective for cancer classification. We utilize two sets of simple statistical methods to identify the topmost class-correlated genes (set 1) and eliminate redundant genes (set 2), respectively. Finally, the selected gene set is integrated with the support vector machine (SVM) classifier. The performances of these simple methodologies are compared with a number of existing methods on ten gene expression benchmark datasets. It is observed that in many datasets, these simple methodologies yield similar efficacy to the complex and computationally expensive approaches using only a small number of genes.
Analysis of Single-phase Grounding Fault in Low-resistance Grounding System Containing Inverter Interfaced Distributed Generator

In the low-resistance grounding system with inverter interfaced distributed generator (IIDG), the IIDG widely uses the neutral point through the low-resistance grounding method. But the IIDG, which adopts the neutral point grounding through a low resistance, will affect the fault characteristics of the original low-resistance grounding system. This paper uses the symmetrical component method to establish a single-phase grounding fault model for the distribution network where the neutral points of the IIDG and the main network are grounded with low resistance. The fault current, the zero-sequence current, and the three-phase current of the line are analyzed when the upstream line of the grid connection point, the downstream line of the grid connection point, and the adjacent feeder fail. Finally, a simulation model was built using Matlab/Simulink to verify the correctness of the analysis. The conclusion provides a basis for the protection configuration of the distribution network in which the neutral points of the IIDG and the main network are grounded with low resistance.
2D Local Exterior Sound Field Reproduction Using an Addition Theorem Based on Circular Harmonic Expansion

Exterior sound field reproduction often struggles with reproduction accuracy over an entire exterior field. In this paper, we propose a local sound field reproduction method based on conventional mode-matching method using an addition theorem for circular harmonics. Instead of reproducing an entire exterior field, the proposed method aims to reproduce partial interior sound areas within an entire sound field. We conducted simulations to reproduce focused sources, as well as experiments in an anechoic chamber. The results demonstrate that the proposed method can achieve enhanced reproduction accuracy in areas of interest.
Simple routing algorithm with link discovery between source and destination hosts in SDN networks

The worldwide expansion of the network devices led to difficulties with network management and routing mechanisms related to dynamic adapting to the network needs. SDN provides a centralized global network view, maintenance, and management of network devices with vendor-specific configurations. Its main focus is routing the network traffic, load balancing the network, and improving the QoS. This paper proposes a Simple Routing algorithm with Link Discovery between source and destination hosts in SDN networks.
A novel dual‐band branch line coupler based on strip‐shaped complementary split ring resonators

In this article, a novel dual‐band branch line coupler is presented. The dual‐band operation is realized by the LH‐RH transmission line composed of strip‐shaped complementary split ring resonators (CSRRs) and series gap, which can produce LH band around 900 MHz and RH band around 1800 MHz. The performances of the designed device at two operating frequencies are demonstrated by simulated and measured results, which are in good agreement. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 2859–2862, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22873
Improved dual‐mode double‐ring resonator with radial stub for UWB‐filter design

An improved filter design of a dual‐mode double‐ring resonator with radial stub for ultra‐wideband (UWB) applications is presented in this paper. Based on the double‐ring resonator and adjusted voltage/current couplings, two radial stubs are added to the outer ring in order to construct the band‐pass filter. The dual‐mode double‐ring resonator exhibits wideband responses, and the radial stubs enhance the bandwidth of the operating‐frequency band. Thus, an alternative approach to improve the bandwidth of the conventional dual‐mode double‐ring resonator, is presented. The experimental and simulation results are given and discussed. © 2005 Wiley Periodicals, Inc. Microwave Opt Technol Lett 44: 219–222, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.20593
A Simple Decoupling Method for Patch Antennas with Restored Radiation Patterns

A simple decoupling method for multiple patch antennas is presented. The proposed 1×2 multiple patch antennas are placed side by side with zero spacing. By inserting metallic vias, the coupled patch antennas are separated electromagnetically, although they are physically placed together. The isolation between the two ports can be enhanced, together with restored radiation patterns. To verify the proposed idea, 1 × 2 multiple patch antennas are designed, fabricated and measured. Good agreement is observed between the measured and simulated results. The measured overlapped impedance bandwidths are 1.34% with isolation larger than 18 dB. It should be highlighted that the measured radiation patterns show good symmetry and the maximum radiation is along z-axis, which verifies the proposed radiation patterns restoration. Over the designed frequency band, the measured envelope correlation coefficient (ECC) is less than 0.07, good enough for diversity or multiple-input and multiple-output (MIMO) systems.
Comparison of C-Reactive Protein in Dried Blood Spots and Saliva of Healthy Adolescents

Background/Aim Determining C-reactive protein (CRP) by non-invasive methods is of great interest for research addressing inflammation in young people. However, direct comparisons of such methods applied in children and adolescents are lacking so far. This study aimed to evaluate the association between CRP measured in dried blood spots (DBS CRP) and in saliva (sCRP), two less invasive alternatives to venipuncture, in 12- to 14-year-old adolescents. To evaluate the validity of both measurements in the context of biobehavioral studies, the potential of DBS CRP and sCRP to discriminate between defined BMI subgroups was assessed. Materials and Methods CRP levels in DBS and saliva collected from 87 healthy adolescents (M = 13.25 years, SD = 0.30, 51.7% females) were determined using high sensitive CRP ELISA for serum and salivary CRP ELISA, respectively. Characteristics and correlation of both measurements were assessed for the total sample and for three subgroups classified by BMI percentile ranges (A: ≤ 25; B: 26–74; C: ≥ 75). Results In the total sample, DBS CRP and sCRP were significantly associated (r = 0.59, p < 0.001). Splitting the sample into BMI-dependent subgroups revealed similarly strong associations of DBS CRP with sCRP for all three groups (A: r = 0.51; B: r = 0.61; C: r = 0.53). However, comparing the mean CRP values per BMI subgroup, one-way ANOVA reported significant differences for DBS CRP, but not for sCRP mean values. Conclusions The significant correlation of DBS CRP with sCRP was independent of the investigated BMI range groups, yet BMI-dependent distinction was only provided by DBS CRP mean values. Overall, our results suggest that DBS CRP is likely to reflect systemic inflammation more precisely. Salivary CRP can be alternatively determined in studies with adolescents when conditions require it, given the oral health status is assessed. Considering that DBS CRP and sCRP share only 35% of common variance, further studies should examine their specific validity.
Ba-SAPO-34 Zeolite Membrane for CO2/N2 Separation: Process Optimization

In the present research, Ba-SAPO-34 membrane was formed using microwave heating and ion-exchange process. The membrane was subjected to CO2/N2 separation process considering 3 independent process variables as temperature, pressure difference across the membrane and CO2 % in the feed. Response surface methodology coupled with central composite design, available in Design Expert software was used to perform optimization for the 2 response CO2 permeance and CO2/N2 separation selectivity as a function of the 3 independent process variables. The optimum CO2 permeance and CO2/N2 separation selectivity was 17.54x10-7 mol/m2.s. Pa and 58.82 respectively at 30 oC, 145.10 kPa pressure difference and 5 % CO2 in the feed.
Towards developing competency‐based measures for project managers in mass house building projects in developing countries

Within the human resource management (HRM) genre, the identification and development of appropriate competency‐based measures is widely seen as the only viable means for validating and engendering managerial best practices. A competency‐based conceptual model is proposed towards the development of a taxonomy of project managers' (PMs') performance measures in mass house building projects (MHBPs). The model reflects elements of both performance behaviours and outcomes in predicting the performance of PMs at the construction phase of the project life cycle. Data were elicited from members of the Ghana Real Estate Developers Association (GREDA), whose speciality is the construction of residential buildings, to test the validity of this conceptual model. The findings, which confirm the validity of the model, demonstrate the suitability and potential usefulness of this model for developing a competency‐based agenda towards the professional development of PMs involved in the implementation of MHBPs in developing countries, like Ghana. The model could, therefore, form the basis for curriculum development, recruitment and selection, team deployment and job matching, career development and succession planning to facilitate the achievement of managerial best practices in MHBPs.
Impact of Mental Health on Wellness in Adult Workers

Wellness in adult workers is intimately associated with better quality of life in individuals, as well as in the family, community, workplace, and country. This study aimed to examine the status of wellness in adult workers and to identify the factors that influence wellness. A descriptive survey was conducted with 260 adult workers. T- test and one-way ANOVA with post-hoc Scheffe test were used to analyze the data. Multiple regression analysis was performed on stress, depression, anxiety, well-being, self-efficacy, and perceived health status. The regression model for wellness in adult workers was significant (F = 42.21, p < 0.001), with an explanatory power of 0.558. Depression (β = −0.306) was identified as the most influential factor for wellness in adult workers, followed by self-efficacy (β = 0.280) and well-being (β = 0.264). Depression, stress, and anxiety negatively influenced wellness, whereas self-efficacy, well-being, and perceived health status positively influenced wellness. Study findings suggest the need to develop intervention programs for workers that decrease stress, depression, and anxiety, and incorporate self-efficacy strategies.
Concept Creep and Psychiatrization

Some aspects of psychiatrization can be understood as forms of concept creep, the progressive expansion of concepts of harm. This article compares the two concepts and explores how concept creep sheds light on psychiatrization. We argue that although psychiatrization is in some respects a broader concept than concept creep, addressing institutional and societal dimensions of the expanding reach of psychiatry in addition to conceptual change, concept creep is broader in other respects, viewing the expansion of psychiatric concepts as examples of the broadening of a more extensive range of harm-related concepts. A concept creep perspective on psychiatrization clarifies the different forms of expansion it involves, the centrality of harm to it, its benefits as well as its costs, its variations across individuals and groups, and the drivers of psychiatrization in the general public and in fields beyond psychiatry.
Seasonal Dynamics and Persistency of Endophyte Communities in Kalidium schrenkianum Shifts Under Radiation Stress

Endophytes are essential components of plant microbiota. Studies have shown that environmental factors and seasonal alternation can change the microbial community composition of plants. However, most studies have mainly emphasized the transitive endophyte communities and seasonal alternation but paid less attention to their persistence through multiple seasons. Kalidium schrenkianum is a perennial halophyte growing in an arid habitat with radiation stress (137Cs) in northwest China. In this study, K. schrenkianum growing under different environmental stresses were selected to investigate the dynamics and persistency of endophytic microbial communities amid seasons in a year. The results showed that Gammaproteobacteria and unassigned Actinobacteria were the most dominant bacterial communities, while the most dominant fungal communities were Dothideomycetes, unassigned Fungi, and Sodariomycetes. The bacterial community diversity in roots was higher than that in aerial tissues, and root communities had higher diversity in summer and autumn. In contrast, the fungal community diversity was higher in aerial tissues comparing to roots, and the highest diversity was in spring. Season was a determinant factor in the microbial community composition in the roots but not in the aerial tissues. RaupCrick index suggested that the bacterial communities were mainly shaped by stochastic processes. Our research investigated the community traits and members with temporal persistency. For example, bacterial taxa Afipia, Delftia, Stenotrophomonas, Xanthomonadaceae_B_OTU_211, and fungal taxa Neocamarosporium F_OTU_388, F_OTU_404, F_OTU_445, and unassigned Fungi F_OTU_704, F_OTU_767 showed higher frequencies than predicted in all the four seasons tested with neutral community model. The networks of co-occurrence associations presented in two or more seasons were visualized which suggested potential time-continuous core modules in most communities. In addition, the community dynamics and persistency also showed different patterns by radiation levels. Our findings would enhance our understanding of the microbial community assembly under environmental stress, and be promising to improve the development of integrated concept of core microbiome in future.
Use of toxicokinetic and toxicodynamic data to reduce uncertainties when setting occupational exposure limits for pharmaceuticals

Abstract Occupational exposure limits for pharmaceutical active ingredients should be based on all of the available preclinical and clinical data generated during drug development, including toxicokinetic (TK) and toxicodynamic (TD) data. The framework for limit setting proposed by the International Programme on Chemical Safety (IPCS) subdivides traditional 10‐fold uncertainty factors (UFs) into separate partial‐log default values based upon TK and TD considerations and allows for incorporation of compound‐specific data when available. We propose an extension of this method by providing more detailed guidance on the development and use of TK and TD data to maximize the use of scientific information in the limit setting process. Specific recommendations are made on how TK and TD parameters may be used to support replacement of default UFs with data‐derived values. Proper application of TK and TD data reduces the uncertainties when establishing limits for specific compounds and provides better assurance tha.
Man, road and vehicle: risk factors associated with the severity of traffic accidents.

OBJECTIVE To describe the main characteristics of victims, roads and vehicles involved in traffic accidents and the risk factors involved in accidents resulting in death. METHODS A non-concurrent cohort study of traffic accidents in Fortaleza, CE, Northeastern Brazil, in the period from January 2004 to December 2008. Data from the Fortaleza Traffic Accidents Information System, the Mortality Information System, the Hospital Information System and the State Traffic Department Driving Licenses and Vehicle database. Deterministic and probabilistic relationship techniques were used to integrate the databases. First, descriptive analysis of data relating to people, roads, vehicles and weather was carried out. In the investigation of risk factors for death by traffic accident, generalized linear models were used. The fit of the model was verified by likelihood ratio and ROC analysis. RESULTS There were 118,830 accidents recorded in the period. The most common types of accidents were crashes/collisions (78.1%), running over pedestrians (11.9%), colliding with a fixed obstacle (3.9%), and with motorcycles (18.1%). Deaths occurred in 1.4% of accidents. The factors that were independently associated with death by traffic accident in the final model were bicycles (OR = 21.2, 95%CI 16.1;27.8), running over pedestrians OR = 5.9 (95%CI 3.7;9.2), collision with a fixed obstacle (OR = 5.7, 95%CI 3.1;10.5) and accidents involving motorcyclists (OR = 3.5, 95%CI 2.6;4.6). The main contributing factors were a single person being involved (OR = 6.6, 95%CI 4.1;10.73), presence of unskilled drivers (OR = 4.1, 95%CI 2.9;5.5) a single vehicle (OR = 3.9, 95%CI 2,3;6,4), male (OR = 2.5, 95%CI 1.9;3.3), traffic on roads under federal jurisdiction (OR = 2.4, 95%CI 1.8;3.7), early morning hours (OR = 2.4, 95%CI 1.8;3.0), and Sundays (OR = 1.7, 95%CI 1.3;2.2), adjusted according to the log-binomial model. CONCLUSIONS Activities promoting the prevention of traffic accidents should primarily focus on accidents involving two-wheeled vehicles that most often involves a single person, unskilled, male, at nighttime, on weekends and on roads where they travel at higher speeds.
Design and Development of a Mobile Health (mHealth) Platform for Dementia Prevention in the Prevention of Dementia by Mobile Phone Applications (PRODEMOS) Project

Background: Mobile health (mHealth) has the potential to bring preventive healthcare within reach of populations with limited access to preventive services, by delivering personalized support at low cost. Although numerous mHealth interventions are available, very few have been developed following an evidence-based rationale or have been tested for efficacy. This article describes the systematic development of a coach-supported mHealth application to improve healthy lifestyles for the prevention of dementia and cardiovascular disease in the United Kingdom (UK) and China. Methods: Development of the Prevention of Dementia by Mobile Phone applications (PRODEMOS) platform built upon the experiences with the Healthy Aging Through Internet Counseling in the Elderly (HATICE) eHealth platform. In the conceptualization phase, experiences from the HATICE trial and needs and wishes of the PRODEMOS target population were assessed through semi-structured interviews and focus group sessions. Initial technical development of the platform was based on these findings and took place in consecutive sprint sessions. Finally, during the evaluation and adaptation phase, functionality and usability of the platform were evaluated during pilot studies in UK and China. Results: The PRODEMOS mHealth platform facilitates self-management of a healthy lifestyle by goal setting, progress monitoring, and educational materials on healthy lifestyles. Participants receive remote coaching through a chat functionality. Based on lessons learned from the HATICE study and end-users, we made the intervention easy-to-use and included features to personalize the intervention. Following the pilot studies, in which in total 77 people used the mobile application for 6 weeks, the application was made more intuitive, and we improved its functionalities. Conclusion: Early involvement of end-users in the development process and during evaluation phases improved acceptability of the mHealth intervention. The actual use and usability of the PRODEMOS intervention will be assessed during the ongoing PRODEMOS randomized controlled trial, taking a dual focus on effectiveness and implementation outcomes.
Specific Immunotherapy in a Murine Model of Grass Pollen (Phl p5b)-Induced Airway Inflammation

Background: The use of ovalbumin as a model allergen in murine models of allergic asthma is controversially discussed since it is not an aeroallergen and sensitization can only be achieved by using strong Th2-inducing adjuvants. Therefore, in this study, a murine model of asthma has been established in which sensitization against the major grass pollen allergen Phl p5b was performed without using aluminum hydroxide (alum). We used this model for specific immunotherapy. Methods: Female, 5–6-week-old mice were sensitized by six subcutaneous (s.c.) injections of 20 μg Phl p5b followed by four provocations to induce allergic airway inflammation. For desensitization, 1 mg of Phl p5b was injected subcutaneously during allergen challenge for one to a maximum of four times. Three days after the last challenge, the allergic immune response was analyzed. Results: Sensitized and challenged animals showed a significant infiltration of eosinophils into the airways, and the production of interleukin-5 (IL-5) by in vitro re-stimulated splenocytes could be detected. Furthermore, hyper-responsiveness of the airways was verified by invasive measurement of airway resistance in methacholine-challenged animals. Desensitized animals showed a significant reduction of all parameters. Conclusion: In this study, a murine model of asthma has successfully been established by sensitization against the clinically relevant allergen Phl p5b without using alum. S.c. injection of allergen dose dependently led to desensitization of sensitized mice. We suggest that this model is useful to study adjuvant effects of immune modulatory substances on immunotherapy without the interference of alum.