Miracle-dz/UniFAR-FTUs huggingface dataset:
Consistency of Medical Data Using Intelligent Neuron Faster R-CNN Algorithm for Smart Health Care Application

The purpose of this study is to increase interest in health as human life is extended in modern society. Hence, many people in hospitals produce much medical data (EMR, PACS, OCS, EHR, MRI, X-ray) after treatment. Medical data are stored as structured and unstructured data. However, many medical data are causing errors, omissions and mistakes in the process of reading. This behavior is very important in dealing with human life and sometimes leads to medical accidents due to physician errors. Therefore, this research is conducted through the CNN intelligent agent cloud architecture to verify errors in reading existing medical image data. To reduce the error rule when reading medical image data, a faster R-CNN intelligent agent cloud architecture is proposed. It shows the result of increasing errors of existing error reading by more than 1.4 times (140%). In particular, it is an algorithm that analyses data stored by actual existing medical data through Conv feature map using deep ConvNet and ROI Projection. The data were verified using about 120,000 databases. It uses data to examine human lungs. In addition, the experimental environment established an environment that can handle GPU’s high performance and NVIDIA SLI multi-OS and multiple Quadro GPUs were used. In this experiment, the verification data composition was verified and randomly extracted from about 120,000 medical records and the similarity compared to the original data were measured by comparing about 40% of the extracted images. Finally, we want to reduce and verify the error rate of medical data reading.
A Selective PPARγ Modulator Reduces Hepatic Fibrosis

Hepatic fibrosis is the accumulation of excess collagen as a result of chronic liver injury. If left unabated, hepatic fibrosis can lead to the disruption of the liver architecture, portal hypertension, and increased risk of progression to cirrhosis and hepatocellular carcinoma. The thiazolidinedione class of antidiabetic drugs, through their target peroxisome proliferator-activated receptor γ (PPARγ), have protective effects against liver fibrosis, and can inhibit the profibrotic activity of hepatic stellate cells, the major collagen-producing liver cells. However, these drugs have been ineffective in the treatment of established fibrosis, possibly due to side effects such as increased weight and adiposity. Recently, selective PPARγ modulators that lack these side effects have been identified, but their role in treating fibrosis has not been studied. In this study, we tested the effectiveness of one of these selective modulators, SR1664, in the mouse carbon tetrachloride model of established hepatic fibrosis. Treatment with SR1664 reduced the total and type 1 collagen content without increasing body weight. The abundance of activated hepatic stellate cells was also significantly decreased. Finally, SR1664 inhibited the profibrotic phenotype of hepatic stellate cells. In summary, a selective PPARγ modulator was effective in the reduction of established hepatic fibrosis and the activated phenotype of hepatic stellate cells. This may represent a new treatment approach for hepatic fibrosis.
Effect of Temperature on Acute Toxicity of Nitrite to Meagre, Argyrosomus regius (Asso, 1801)

Meagre, Argyrosomus regius, is a candidate marine fish species for aquaculture diversification, presenting a high economic value in the Mediterranean. Tolerance of juvenile meagre to nitrite (NO2-N) was determined relating to temperature. Fish (3.2 ± 0.6 g and 5.4 ± 0.9 cm) were exposed to different NO2-N concentrations in a series of acute toxicity tests by the static renewal method at three temperatures (18, 22, and 26 C) at a pH of 8.0. Low temperature clearly increased tolerance to NO2-N (P < 0.05). The 96-h median lethal concentration (LC50) values of NO2-N were 177.63, 139.55, and 49.61 mg/L, at 18, 22, and 26 C, respectively. The safe levels of NO2-N for juvenile meagre were estimated to be 17.7, 13.9, and 4.9 mg/L at 18, 22, and 26 C, respectively (P < 0.05). This study indicates A. regius is more sensitive to nitrite than other marine fish species cultured in the Mediterranean.
Perception of Dental Caries and Parental Difficulties in Implementing Oral Hygiene for Children Aged Less Than 6 Years: A Qualitative Study

Background: Despite extensive prevention programs, dental hygiene remains inadequate, particularly among children under the age of six, and early childhood caries (ECC) are still a concern. Oral hygiene behavior and preventive practices seem difficult to change at a family level. Aim. The present study aimed to better understand the reasons behind this behavior and to identify the different barriers to the implementation of adequate preventive measures. Methods: A qualitative study was conducted in the pediatric dentistry service of the Montpellier University Hospital (France) in 2019. A thematic analysis concerning three domains was performed: family environment, dental literacy, and oral hygiene. Results. The main barriers encountered by the parents were, respectively, (1) a weakness in the organization of familial life, together with a low-medium family income and a lack of authority, (2) ignorance of the necessity of treating carious primary teeth, and (3) a lack of time for brushing or supervising their children’s teeth. Conclusion: These results showed that oral hygiene and primary teeth care could not be easily achieved in the family environment of the participants, and oral health strategies should be focused not only on children but also on their parents.
Nutrient content affecting Spodoptera frugiperda and Dalbulus maidis occurrence in corn

This work aims to study the effect of the nutrient contents in the leaves of corn on the incidence of Spodoptera frugiperda (Smith) (Lepidoptera: Noctuidae) and Dalbulus maidis (Delong & Wolcott) (Homoptera: Cicadellidae). The treatments were represented by unfertilized corn plants and corn plants fertilized with 250 kg of the formulation 4‐14‐8 (N‐P‐K) +100 kg of ammonium sulfate (AS)/ha and 500 kg of the formulation 4‐14‐8 (N‐P‐K) +200 kg of AS/ha, arranged in randomized blocks with four replicates. Attacks by S. frugiperda and D. maidis were higher as the nitrogen, sulfur, calcium and copper content in the leaves of corn increased. The effects of calcium and copper found in this study were not consistent with that of lower susceptibility associated with higher levels of these nutrients mentioned in the literature. We believe that there was a cumulative effect of the nutrients altogether, building up a nutritiously better vegetable which in turn had less reserve for defense, or that the content of both nutrients in the leaves were not high enough to induce such effects.
Estimation of Viscosity and Yield Stress of Cement Grouts at True Ground Temperatures Based on the Flow Spread Test

The rheology of cement grouts often plays a crucial role in the success of rock grouting. In practice, the rheological parameters should be timely adjusted according to the evolution of grouting pressure, flow rate and injection time. However, obtaining the magnitude of rheological parameters is not easy to achieve under site conditions. More importantly, the ground temperature in deep rock masses is elevated higher than that on the surface or under room conditions, which has been demonstrated to strongly influence the rheological properties of grouts. Reasonable understanding and control of the rheological behavior of cement grouts at true ground temperatures is very important to the quality of grouting. This paper aims to propose a simplified method to approximately estimate the initial yield stress and viscosity of cement grouts for rock grouting under elevated ground temperature that actually exists in deep rock masses, on the basis of the flow spread test. The temperature investigated was controlled between 12 °C and 45 °C to simulate the true ground temperature in rock masses with a maximum depth of 1500 m below the surface. Taking the influences of elevated temperatures into account, a temperature-based model for estimating the initial viscosity of cement grout was successfully developed on the basis of Liu’s model and the results of the flow spread test. However, the yield stress failed to be estimated by the Lapasin model due to the absence of plastic behavior of cement grouts. In contrast, yield stress can be linearly correlated to the measured relative flow area. In this work, it was also found that the dependence of yield stress of cement grouts on relative flow area is a strongly exponential law. The temperature dependence of the viscosity of water was accounted for in both estimations of viscosity and yield stress of grouts. Significantly, it was found that the packing density of cement is dependent on the grout temperature, especially when the temperature is up to 45 °C. The proposed method in this work offers an alternative solution for technicians to reasonably control the rheological properties in the increasing applications of deep rock grouting.
Development of Lipid–Polymer Hybrid Nanoparticles for Improving Oral Absorption of Enoxaparin

Enoxaparin, an anticoagulant that helps prevent the formation of blood clots, is administered parenterally. Here, we report the development and evaluation of lipid–polymer hybrid nanoparticles (LPHNs) for the oral delivery of enoxaparin. The polymer poloxamer 407 (P407) was incorporated into lipid nanoparticles to form gel cores and ensure high encapsulation efficiency and the controlled release of enoxaparin. In vitro results indicated that 30% of P407 incorporation offered higher encapsulation efficiency and sustained the release of enoxaparin. Laser confocal scanning microscopy (LCSM) images showed that LPHNs could not only significantly improve the accumulation of enoxaparin in intestinal villi but also facilitate enoxaparin transport into the underlayer of intestinal epithelial cells. In vivo pharmacokinetic study results indicated that the oral bioavailability of enoxaparin was markedly increased about 6.8-fold by LPHNs. In addition, its therapeutic efficacy against pulmonary thromboembolism was improved 2.99-fold by LPHNs. Moreover, LPHNs exhibited excellent biocompatibility in the intestine. Overall, the LPHN is a promising delivery carrier to boost the oral absorption of enoxaparin.
A new species of Hedyselmis Hinton and notes on the phylogeny of the genus (Coleoptera: Elmidae)

A new species, Hedyselmis belatani sp. nov., is described from West Malaysia, based on morphological characters. The description includes detailed drawings of the most important structures. Four fragments of DNA, three mitochondrial (cox1, cob, rrnL) and one nuclear (SSU), were sequenced and compared with H. opis Hinton and other elmid species. The taxonomic position of H. belatani sp. nov., its distribution and the phylogeny of the genus are discussed.
Type A Trichothecene Diacetoxyscirpenol-Induced Emesis Corresponds to Secretion of Peptide YY and Serotonin in Mink

The trichothecene mycotoxins contaminate cereal grains and have been related to alimentary toxicosis resulted in emetic response. This family of mycotoxins comprises type A to D groups of toxic sesquiterpene chemicals. Diacetoxyscirpenol (DAS), one of the most toxic type A trichothecenes, is considered to be a potential risk for human and animal health by the European Food Safety Authority. Other type A trichothecenes, T-2 toxin and HT-2 toxin, as well as type B trichothecene deoxynivalenol (DON), have been previously demonstrated to induce emetic response in the mink, and this response has been associated with the plasma elevation of neurotransmitters peptide YY (PYY) and serotonin (5-hydroxytryptamine, 5-HT). However, it is found that not all the type A and type B trichothecenes have the capacity to induce PYY and 5-HT. It is necessary to identify the roles of these two emetogenic mediators on DAS-induced emesis. The goal of this study was to determine the emetic effect of DAS and relate this effect to PYY and 5-HT, using a mink bioassay. Briefly, minks were fasted one day before experiment and given DAS by intraperitoneally and orally dosing on the experiment day. Then, emetic episodes were calculated and blood collection was employed for PYY and 5-HT test. DAS elicited robust emetic responses that corresponded to upraised PYY and 5-HT. Blocking the neuropeptide Y2 receptor (NPY2R) diminished emesis induction by PYY and DAS. The serotonin 3 receptor (5-HT3R) inhibitor granisetron totally restrained the induction of emesis by serotonin and DAS. In conclusion, our findings demonstrate that PYY and 5-HT have critical roles in DAS-induced emetic response.
Neuropathological profile of long‐duration amyotrophic lateral sclerosis in military Veterans

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting both the upper and lower motor neurons. Although ALS typically leads to death within 3 to 5 years after initial symptom onset, approximately 10% of patients with ALS live more than 10 years after symptom onset. We set out to determine similarities and differences in clinical presentation and neuropathology in persons with ALS with long vs. those with standard duration. Participants were United States military Veterans with a pathologically confirmed diagnosis of ALS (n = 179), dichotomized into standard duration (<10 years) and long‐duration (≥10 years). The ALS Functional Rating Scale‐Revised (ALSFRS‐R) was administered at study entry and semi‐annually thereafter until death. Microglial density was determined in a subset of participants. long‐duration ALS occurred in 76 participants (42%) with a mean disease duration of 16.3 years (min/max = 10.1/42.2). Participants with long‐duration ALS were younger at disease onset (P = 0.002), had a slower initial ALS symptom progression on the ALSFRS‐R (P < 0.001) and took longer to diagnose (P < 0.002) than standard duration ALS. Pathologically, long‐duration ALS was associated with less frequent TDP‐43 pathology (P < 0.001). Upper motor neuron degeneration was similar; however, long‐duration ALS participants had less severe lower motor neuron degeneration at death (P < 0.001). In addition, the density of microglia was decreased in the corticospinal tract (P = 0.017) and spinal cord anterior horn (P = 0.009) in long‐duration ALS. Notably, many neuropathological markers of ALS were similar between the standard and long‐duration groups and there was no difference in the frequency of known ALS genetic mutations. These findings suggest that the lower motor neuron system is relatively spared in long‐duration ALS and that pathological progression is likely slowed by as yet unknown genetic and environmental modifiers.
2D Coordination Network of Trioxotriangulene with Multiple Redox Abilities and Its Rechargeable Battery Performance

A three-fold symmetric trioxotriangulene derivative with three pyridyl groups as coordinating sites was designed and synthesized. In a cyclic voltammetry measurement, the trioxotriangulene skeleton exhibited a multi-stage redox ability from neutral radical to radical tetra-anion species. In the zinc complex of monoanion species, three pyridyl groups coordinated to the zinc ion to build up a two-dimensional coordination network with a cavity larger than 12 Å in diameter. This complex was utilized as a cathode active material of a lithium ion battery, and it exhibited a capacity of ca. 60 mAh g−1 per the weight of the active material with a stable cycling performance up to 1000 cycles. This work shows that the coordination network formed by the trioxotriangulene-based ligand was effective in the improvement of cycle performance of the organic rechargeable battery.
Comparison of Chicken Strains: Muscle Fibre Diameter and Numbers in Pectoralis superficialis Muscle

This study was performed to evaluate muscle fibre diameter and numbers in Pectoralis superficialis muscle in two different chicken genotypes. A total of 40 adult clinically healthy native chicken and Ross commercial broilers (20 females and 20 males), aged 8-10 weeks, were used. Tissue samples were taken from the middle parts of left and right Pectoralis superficialis muscle. After fixation in 10% buffered formalin solution, sections were prepared, using routine histological techniques. Tissue samples were stained by Hematoxylin and eosin. By using the lattice line graticule (5*5), the total numbers of muscle fibres were determined. Also, the mean diameters of the muscle fibre were measured by using ocular micrometer. Results showed that the mean muscle fibre diameters in native chickens ranged from 29-52.5 µm, whereas in Ross commercial broilers ranged from 31-39 µm. No evident difference between the left and right sides of Pectoralis superficialis muscle was observed in the both diameter and numbers of muscle fibres in both chicken strains. Sex related difference was observed only in the mean muscle fibre diameters of the left sides of Pectoralis superficialis muscle of native chickens. The mean total fibre numbers in native chickens ranged from 74.67-89.33 µm, whereas in Ross commercial broilers ranged from 64-70.67 µm. There were no significant sex differences for the total number of muscle fibres of Pectoralis superficialis muscle of both chicken strains. It is concluded that the both diameter and total fibre number per mm of Pectoralis superficialis muscle in native chickens were higher than those 2
Real-Time Interference Artifacts Suppression in Array of ToF Sensors †

Time of Flight (ToF) sensors are the source of various errors, including the multi-camera interference artifact caused by the parallel scanning mode of the sensors. This paper presents the novel Importance Map Based Median filtration algorithm for interference artifacts suppression, as the potential 3D filtration method. The approach is based on the processing of multiple depth frames, using the extraction of the interference region and application of the interpolation. Considering the limitations and good functionalities of proposed algorithm, the combination with some standard methods was suggested. Performance of the algorithm was evaluated on the dataset consisting of the real-world objects with different texture and morphology against popular filtering methods based on neural networks and statistics.
Efficacy of fluopyram applied by chemigation on controlling eggplant root-knot nematodes (Meloidogyne spp.) and its effects on soil properties

The root-knot nematode (Meloidogyne spp.) is one of the major challenges in eggplant (Solanum melongena L.) production. Fluopyram, known to be an effective fungicide, is also used for controlling root-knot nematode. However, in China, little information is currently available regarding the efficacy of fluopyram via chemigation against root-knot nematode and its effects on soil properties. For this, the objective of this work was to test mortality of root-knot nematode, functional diversity of soil microbial community, activity of soil enzyme after fluopyram applicated by chemigation. The results of two field experiments revealed that concentration of 60 g·ha-1 fluopyram applied with 200 L·ha-1 irrigation water at 2 L·h-1 flow velocity was the most effective chemigation parameters for controlling eggplant against root-knot nematode. The functional diversity of the soil microbial community was significantly affected by fluopyram. The activities of soil urease and β—glucosidase decreased during the initial stages but recovered at later stages. In brief, fluopyram has advantageous for the efficient control of root-knot nematode with no deleterious effects on soil properties as well as chemigation is positive for application in karst landscape in Guangxi.
Outcome of Very Low and Low Birth Weight Infants with Esophageal Atresia: Results of the Turkish Esophageal Atresia Registry

Abstract Introduction The data of the Turkish Esophageal Atresia Registry (TEAR) was evaluated to define the outcome of very low birth weight (VLBW) and low BW (LWB) infants with esophageal atresia (EA). Materials and Methods The data registered by 24 centers between 2014 and 2018 were evaluated for demographic features, prenatal findings, associated anomalies, surgical treatment, and outcome. Patients were enrolled in three groups according to their BWs (VLBW <1,500 g), LWB = 1,500–2,500 g), and normal BW (NBW; >2,500 g). Results Among the 389 cases, there were 37 patients (9.5%) in the VLBW group, 165 patients (42.4%) in the LBW group, and 187 patients (48.1%) in the NBW group. Prenatal diagnosis rates were similar among the three groups (29.7, 34.5, and 24.6%, respectively). The standard primary anastomosis was achieved at a significantly higher rate in NWB cases than in the other groups (p < 0.05). In patients with tracheoesophageal fistula (TEF), patients of the NBW group had significantly higher rates of full oral feedings, when compared with VLBW and LBW cases (p < 0.05). At the end of the first year, when we evaluate all patients, the number of cases with fistula recanalization and esophageal anastomotic strictures (AS) requiring esophageal dilatation was similar among the groups. The weight and height measurements at 6 months and 1 year of age of the survivors were similar in all the groups. The overall mortality rate was significantly higher in the VLBW and LBW groups, when compared with the NBW patients, even in patients with tension-free anastomosis (p < 0.05). The incidence of the associated anomalies was 90.6% in cases with mortality, which was significantly higher than in survivors (59.6%; p < 0.05). According to Spitz's classification, the survival rate was 87.1% in class I, 55.3% in class II, and 16.7% in class III. The most common causes of mortality were associated with cardiovascular diseases, pneumonia, and sepsis. Conclusion The national data of TEAR demonstrates that the developmental and feeding parameters are better in NBW patients. Although VLBW patients have higher risk of developing fistula canalization than the LBW and NBW groups, long-term complications, such as anastomotic strictures, weight, and height values, after 1 year are similar in both groups. According to our results, associated anomalies and LBWs are still significant risk factors for mortality in cases with EA.
Combination of HIV-1 and Diabetes Enhances Blood Brain Barrier Injury via Effects on Brain Endothelium and Pericytes

Despite combined antiretroviral therapy (ART) achieving efficient HIV replication control, HIV-associated neurocognitive disorders (HAND) continue to be highly prevalent in HIV-infected patients. Diabetes mellitus (DM) is a well-known comorbidity of HAND in HIV-infected patients. Blood brain barrier (BBB) dysfunction has been linked recently to dementia development, specifically in DM patients. BBB injury exists both in HIV and DM, likely contributing to cognitive decline. However, its extent, exact cellular targets and mechanisms are largely unknown. In this report, we found a decrease in pericyte coverage and expression of tight junction proteins in human brain tissues from HIV patients with DM and evidence of HAND when compared to HIV-infected patients without DM or seronegative DM patients. Using our in vitro BBB models, we demonstrated diminution of barrier integrity, enhanced monocyte adhesion, changes in cytoskeleton and overexpression of adhesion molecules in primary human brain endothelial cells or human brain pericytes after exposure to HIV and DM-relevant stimuli. Our study demonstrates for the first-time evidence of impaired BBB function in HIV-DM patients and shows potential mechanisms leading to it in brain endothelium and pericytes that may result in poorer cognitive performance compared to individuals without HIV and DM.