Miracle-dz/UniFAR-FTUs huggingface dataset:
High-Risk HPV Testing in Primary Screening for Cervical Cancer in the Public Health System, São Paulo, Brazil

Every year there are approximately 16,000 new cases of cervical cancer in Brazil. Novel screening technologies may reduce this number by expanding the population coverage but also by improving the detection rate of precursor lesions. We aimed to evaluate human papillomaviruses (HPV)-DNA testing in the context of routine cervical cancer screening in the public health system of the city of São Paulo, Brazil. Women participating in the primary screening program were invited to enroll. Liquid-based cytology samples were collected and cytology and Hr-HPV DNA testing were performed in parallel. Cytologists were blind to HPV results. Women older than 24 years with a positive high-risk HPV test and/or cytology class ≥ ASC-US were referred to colposcopy. From December 2014 to December 2016, 16,102 women joined the study. High-risk human papillomavirus (HR HPV) DNA prevalence was 14.9%, whereas cytologic abnormalities were found in 7.2% of the women. Per protocol, 1,592 Hr-HPV+ women, in addition to 72 patients with cytologic classification > low-grade squamous intraepithelial lesion (LSIL) were referred. A total of 80 cervical intraepithelial neoplasia (CIN2+) cases were diagnosed, 79 were Hr-HPV DNA+ and 18 had normal cytology. Hr-HPV DNA detected a significant number of patients with premalignant lesions missed by cytology and all 16 CIN3+ cases were Hr-HPV DNA+. HPV genotyping may be useful in the management of Hr-HPV+ women, reducing the burden of colposcopic referral for those harboring genotypes with a weaker association to CIN3+. Use of HPV-DNA testing was shown to be feasible and advantageous over current cytologic screening in the public health system.
Dairy foods and health: an umbrella review of observational studies

Abstract Evidence on consumption of dairy foods and human health is contradictory. This study aimed to summarize the level of evidence of dairy consumption on various health outcomes. A systematic search for meta-analyses was performed: study design, dose–response relationship, heterogeneity and agreement of results over time, and identification of potential confounding factors were considered to assess the level of evidence. Convincing and probable evidence of decreased risk of colorectal cancer, hypertension and cardiovascular disease, elevated blood pressure and fatal stroke, respectively, was found for total dairy consumption; possible decreased risk of breast cancer, metabolic syndrome, stroke and type-2 diabetes, and increased risk of prostate cancer and Parkinson’s disease was also found. Similar, yet not entirely consistent evidence for individual dairy products was reported. Among potential confounding factors, geographical localisation and fat content of dairy have been detected. In conclusions, dairy may be part of a healthy diet; however, additional studies exploring confounding factors are needed to ascertain the potential detrimental effects.
Financial Strain and Intimate Partner Violence Against Married Women in Postreform China: Evidence From Chengdu

The primary goal of this study is to link both subjective and objective indicators of financial strain to two distinct dimensions of intimate partner violence (IPV) against women—the husband’s violent behavior and gendered control—in postreform China. The data for this study were drawn from a community survey conducted in Chengdu, the capital of Sichuan province, in 2017 (N = 340). By utilizing the family stress model and quantitative methods, the following results emerged from a series of multivariate statistical analyses: (a) among married women, self-perceived financial strain is significantly and positively associated with the risk of experiencing the husband’s perpetration of violent behavior and financial control; (b) low family income significantly elevates the likelihood of the husband’s exertion of personal and financial control over the wife, albeit the effect is weaker for financial control; and (c) unemployment of the husband significantly increases the likelihood of the husband’s exertion of financial controlling behavior against his wife. These results underscore the importance of gender and income inequalities in research on IPV against women in postreform China. These findings also cross-culturally substantiate the family stress model that has been utilized previously to examine the multifaceted associations between economic hardship and IPV in the U.S. Policy makers, academic researchers, and health practitioners are urged to recognize both subjective and objective financial strains as social and psychological determinants of IPV against women in postreform China.
Population Survey of the Bengal Slow Loris, Nycticebus bengalensis, in Meghalaya, Northeast India

Abstract: The Bengal slow loris Nycticebus bengalensis is a nocturnal prosimian that inhabits the forests of northeastern India. As with many nocturnal prosimian species, little is known about its behavior or ecology; even less information is available on its distribution and population status in northeastern India. We conducted a survey of forest patches in the state of Meghalaya, in northeast India, in order to assess its distribution. A secondary aim of our study was to estimate the severity of threats that may affect the long-term survival of the slow loris in Meghalaya. We surveyed sixteen sites in six districts. Slow lorises were seen in only two sites; however, information obtained through secondary sources indicated that they were present in a number of other forest patches across the state. Many of the forests surveyed were severely affected by logging, poaching and forest fires; it is imperative that conservation measures, aimed at protecting existing forest patches, be implemented in order to ensure the long-term survival of the slow loris and other mammals in the state.
Profit Centers, Single-Source Suppliers and Transaction Costs

This research was supported by the Reginald Jones Center, Wharton School, the Management of the '90s Program at MIT, and by a grant from the National Science Foundation, SES-880031 0. We appreciate the comments of Bruce Kogut, Dan Levinthal, Marshall Meyer, Oliver Williamson, and two anonymous reviewers. This paper addresses criticisms of transaction-cost theory that it overstates the effect of asset specialization on vertical integration and understates the costs of managing interunit relationships within an organization, particularly for nonstandard organizations and markets. We apply the theory simultaneously to decentralized supply relationships in a manufacturing corporation and to the corporation's relationships with single-source suppliers. Our results support the core proposition of the theory-that specialized assets have lower transaction costs within the organization. However, the hybrid characteristics of these supply relationships challenge both the theory's basic assumptions and its predictive power. Corporate decentralization and relational contracting in the market diminish the role of asset specificity as a necessary condition for low transaction costs in-house and as a sufficient condition for high transaction costs in the market. Therefore, how the theory should be used as a predictor of shifts in the current boundaries of the corporation is unclear. '
Highly efficient nickel (II) removal by sewage sludge biochar supported α-Fe2O3 and α-FeOOH: Sorption characteristics and mechanisms

A novel approach was employed to load α-Fe2O3 and α-FeOOH onto sewage sludge biochar (SBC) with the purpose of efficient nickel (Ni) removal. A high Ni(II) adsorption capacity of 35.50 mg·g-1 in 100 ppm Ni(II) solution with 10 mg modified sewage sludge biochar (MSBC) was achieved. The adsorption kinetic and isotherm were fitted well by the pseudo-second-order model and the Langmuir model, respectively. The optimal pH was found around a neutral pH of 7. The adsorption mechanisms of Ni(II) onto MSBC were described as the synergistic effects of electrostatic attraction, ion exchange, inner-sphere complexation and co-precipitation. The initial rapid adsorption phenomenon could be attributed to electrostatic attraction and ion exchange, and then inner-sphere complexation and co-precipitation acted as a crucial role in the following step. The remarkable performance of MSBC provides an effective waste utilization approach to simultaneous sewage sludge recycle and Ni removal from aqueous solution.
Improved Assessment of Muscle Excitation From Surface Electromyograms in Isometric Muscle Contractions

We introduce two novel methods for the estimation of muscle excitation from surface electromyograms (EMGs), the so called cumulative motor unit activity index (CAI) and robust CAI (rCAI). Both methods aim to remove the detected motor unit action potential (MUAP) contributions from EMG but do not assess the individual motor unit spike trains. Instead, they directly estimate the cumulative motor unit spike train (CST). We compared the methods with the spatially averaged root-mean-square (RMS) envelope of the EMG signals and with the CST, estimated by the previously introduced convolution kernel compensation (CKC) method. The tests on synthetic EMG with known muscle excitation profiles demonstrated superior accuracy of newly introduced methods. In the case of 64 EMG channels and 20-dB noise, the RMS, CAI, rCAI, and CKC estimators, calculated on 0.125-s-long signal epochs, yielded the normalized RMS error (NRMSE) of 14.5% ± 2.8%, 4.4% ± 3.2%, 4.1% ± 1.8%, and 6.3% ± 4.6%, respectively. In the experimental signals from wrist extensors and flexors, the RMS, CAI, rCAI, and CKC estimations were compared to exerted muscle force. When calculated on 0.125-s-long signal epochs, they yielded the NRMSE of 11.2% ± 3.5%, 8% ± 5.6%, 10.7% ± 6.8%, and 9.0% ± 4.9%, respectively. Therefore, the newly introduced methods exhibit accuracy that is comparable to at least 200-times slower CKC method.
A symbiotic balancing act: arbuscular mycorrhizal specificity and specialist fungus gnat pollination in the mycoheterotrophic genus Thismia (Thismiaceae).

BACKGROUND AND AIMS Mycorrhizal associations in mycoheterotrophic plants are generally more specialized than in autotrophs. Mycoheterotrophs typically bear small, inconspicuous flowers that often self-pollinate to maximize seed set, although some have structurally complex flowers indicative of xenogamy. A trade-off has previously been proposed between specialization in these above- and below-ground symbioses, although empirical data are lacking. METHODS We used next-generation DNA sequencing to compare the mycorrhizal communities from the roots of a mycoheterotrophic species, Thismia tentaculata (Thismiaceae), and its neighbouring autotrophs. We furthermore conducted detailed assessments of floral phenology and pollination ecology, and performed artificial pollination experiments to determine the breeding system. KEY RESULTS Thismia tentaculata maintains a symbiotic association with a single arbuscular mycorrhizal Rhizophagus species. The flowers are pollinated by a single species of fungus gnats (Corynoptera, Sciaridae), which are attracted by the yellow pigments and are temporarily restrained within the perianth chamber before departing via apertures between the anthers. The plants are self-compatible but predominantly xenogamous. CONCLUSIONS Our findings demonstrate that T. tentaculata maintains highly specialized associations with pollinators and mycorrhizal fungi, both of which are widely distributed. We suggest that specialization in multiple symbiotic interactions is possible in mycoheterotrophs if redundant selective pressures are not exerted to further restrict an already constrained suite of life-history traits.
Red blood cells participate in reverse cholesterol transport by mediating cholesterol efflux of high-density lipoprotein and apolipoprotein A-I from THP-1 macrophages

Abstract High-density lipoprotein (HDL) plays a main role in reverse cholesterol transport (RCT), one of the most important functions for preventing atherosclerosis. Recent reports have shown that red blood cells (RBCs) can be associated with RCT, an interaction facilitated by albumin. However, the RCT function of RBCs has not been thoroughly elucidated. In this study, the RCT function of RBCs was assessed using cholesterol efflux capacity (CEC) assays, in which [3H]-labeled cholesterol-loaded human acute monocytic leukemia (THP-1) macrophages were incubated with RBCs as a cholesterol acceptor in the presence or absence of HDL or its main component protein apolipoprotein A-I (apoA-I). The CEC of RBCs was found to be dose dependent, enabling uptake of cholesterol from THP-1 macrophages through apoA-I and HDL, and directly from apoA-I and HDL in medium without the presence THP-1 macrophages. Moreover, RBCs could exchange cholesterol with HDL in a bidirectional manner but could only exchange cholesterol with apoA-I in a single direction. Although albumin promoted the movement of cholesterol, synergistic effects were not observed for both apoA-I and HDL, in contrast to previous findings. These results strongly suggested that RBCs may play important roles in RCT by mediating cholesterol efflux as temporary cholesterol storage.
Contingency Help: The Main Strategy of Iranian Nurses in Dealing With the Family of the End-of-Life Patients

Families are struggling with many challenges in the final stages of patient life. It is important to understand what actions nurses do for the family of the end-of-life (EOL) patients. This study aimed to explain the main strategy of nurses’ dealing with the family of the EOL patients. Data were analyzed using conventional content analysis. Semistructured interviews were conducted on 32 nurses from hospitals in Tehran. Nurses used six measures of explaining the bitter reality, effective communication, management of violence, referral, consolation, and reinforcement. “Contingency help” was conceptualized as the main strategy. Nurses through “contingency help” were involved in solving the emotional, physical, financial, and spiritual needs of the family. Nurses will be able to apply the results of this study to the development of care policies for the family of the EOL patients.
Natural, But Not Supernatural, Literal Immortality Affirmation Attenuates Mortality Salience Effects on Worldview Defense in Atheists

The present research explored whether atheists managing death awareness would be effectively buffered by affirmations of supernatural and/or natural literal immortality. Prior data were reanalyzed, revealing ambiguous results, so further experiments were conducted. In Study 1 (n = 382), atheists were randomly assigned to a supernatural afterlife-confirmed (vs. afterlife-disconfirmed) prime, an MS (vs. control topic) prime, and then given an opportunity to engage in secular worldview defense. In Study 2 (n = 360), atheists were randomly assigned to supernatural (afterlife) versus natural (medical indefinite life extension; MILE) immortality prime, an MS (vs. control topic) prime, and then given an opportunity to engage in secular worldview defense. Atheists managing death awareness increased worldview defense in the supernatural/afterlife conditions but that effect was eliminated in the MILE condition. These findings are consistent with the terror management theory perspective on worldview defense. Implications for theory and research are discussed.
Draft Genome Sequence of Alkalicoccus saliphilus DSM 15402T, a Haloalkaliphilic Bacterium Isolated from a Mineral Pool

The haloalkaliphilic bacterium Alkalicoccus saliphilus DSM 15402T was isolated from a mineral pool. It grows aerobically at an optimum of 15% (wt/vol) salinity and pH 9.0. The draft genome consists of approximately 3.52 Mb and contains 3,434 predicted genes. Various genes are potentially involved in the adaptation mechanisms for both osmotic stress and pH homeostasis, providing insight into specific adaptations to this double-extreme environment. ABSTRACT The haloalkaliphilic bacterium Alkalicoccus saliphilus DSM 15402T was isolated from a mineral pool. It grows aerobically at an optimum of 15% (wt/vol) salinity and pH 9.0. The draft genome consists of approximately 3.52 Mb and contains 3,434 predicted genes. Various genes are potentially involved in the adaptation mechanisms for both osmotic stress and pH homeostasis, providing insight into specific adaptations to this double-extreme environment.
High Quality Draft Genome of Arogyapacha (Trichopus zeylanicus), an Important Medicinal Plant Endemic to Western Ghats of India

Arogyapacha, the local name of Trichopus zeylanicus, is a rare, indigenous medicinal plant of India. This plant is famous for its traditional use as an instant energy stimulant. So far, no genomic resource is available for this important plant and hence its metabolic pathways are poorly understood. Here, we report on a high-quality draft assembly of approximately 713.4 Mb genome of T. zeylanicus, first draft genome from the genus Trichopus. The assembly was generated in a hybrid approach using Illumina short-reads and Pacbio longer-reads. The total assembly comprised of 22601 scaffolds with an N50 value of 433.3 Kb. We predicted 34452 protein coding genes in T. zeylanicus genome and found that a significant portion of these predicted genes were associated with various secondary metabolite biosynthetic pathways. Comparative genome analysis revealed extensive gene collinearity between T. zeylanicus and its closely related plant species. The present genome and annotation data provide an essential resource to speed-up the research on secondary metabolism, breeding and molecular evolution of T. zeylanicus.
Step It Up! Prioritization of Community Supports for Walking Among US Adults

Purpose: Step It Up! The Surgeon General’s Call to Action to Promote Walking and Walkable Communities (Call to Action) presents goals and supporting strategies to promote walking. We assessed the presence and prioritization of 4 community supports for walking related to the goals of the Call to Action from the perspective of US adults. Design: Cross-sectional web-based survey. Setting: US adults. Participants: A total of 4043 respondents. Measures: SummerStyles 2016 survey assessing the reported presence and prioritization of 4 community supports for walking. Analysis: Estimated prevalence of the presence of supports overall and by demographic characteristics, and prevalence and adjusted prevalence ratios of their prioritization. Results: The most commonly reported community supports for walking were access to walkable locations (46.5%) and safe streets (29.2%), followed by walking groups (12.9%) and promotional campaigns (9.6%). Access to walkable locations (60.0%) and safe streets (50.6%) were most often prioritized by respondents, followed by promotional campaigns (23.6%) and walking groups (18.8%). Many differences in prioritization by demographic characteristics remained significant after adjusting for presence and other demographic characteristics, such as increased prioritization of all supports with older age groups. Conclusions: Presence and prioritization of community supports for walking varied widely by type of support and by demographic characteristics. Opportunities exist to improve access and public sentiment related to these supports to promote walking in the United States.
Effects of the implementation of a hand hygiene education program among ICU professionals: an interrupted time-series analysis

ABSTRACT Objective: To evaluate the effects that a hand hygiene education program has on the compliance of health professionals in an ICU. Methods: This was a quasi-experimental study with an interrupted time-series design, conducted over a 12-month period: the 5 months preceding the implementation of a hand hygiene education program (baseline period); the 2 months of the intensive (intervention) phase of the program; and the first 5 months thereafter (post-intervention phase). Hand hygiene compliance was monitored by one of the researchers, unbeknownst to the ICU team. The primary outcome measure was the variation in the rate of hand hygiene compliance. We also evaluated the duration of mechanical ventilation (MV), as well as the incidence of ventilator-associated pneumonia (VAP) at 28 days and 60 days, together with mortality at 28 days and 60 days. Results: On the basis of 959 observations, we found a significant increase in hand hygiene compliance rates-from 31.5% at baseline to 65.8% during the intervention phase and 83.8% during the post-intervention phase, corresponding to prevalence ratios of 2.09 and 2.66, respectively, in comparison with the baseline rate (p < 0.001). Despite that improvement, there were no significant changes in duration of MV, VAP incidence (at 28 or 60 days), or mortality (at 28 or 60 days). Conclusions: Our findings indicate that a hand hygiene education program can increase hand hygiene compliance among ICU professionals, although it appears to have no impact on VAP incidence, duration of MV, or mortality.
Regional networking as a competitive advantage? Empirical results from German pig production

Abstract It is often hypothesized that geographical proximity in clusters (or industry districts) has positive effects on firms' access to information and knowledge and on firm competitiveness. We present one of the first empirical tests of this hypothesis in the context of the European agribusiness sector. A large-scale explorative empirical study was conducted in the north-western part of Germany, which is one of Europe's leading pig production regions. The results of the farmer survey show that the cluster in north-western Germany provides good structural preconditions for the comprehensive network participation of pig farmers. These structural preconditions comprise a relatively high number of specialized institutions and the geographical proximity of the actors involved in pig production. Additional analyses show that farmers' participation in partly overlapping business and personal networks has positive effects on access to information, their perceived level of informedness, and the competitiveness of their farms. The results have interesting implications for farm management since they indicate the high relevance of the intensity and quality of farmers' relationships with other actors for farm competitiveness. The results are also helpful for political decision-making and public administration in regions with high livestock densities since they show that the regional deconcentration of livestock production which is sometimes considered more advantageous from an environmental perspective may, at the same time, reduce the competitiveness of livestock production.
Penta-Coordinated Al3+ Stabilized Active Pd Structures on Al2O3 Coated Palladium Catalysts for Methane Combustion.

Supported Pd catalysts are active in catalyzing the highly exothermic methane combustion reaction but tend to deactivate due to local hyperthermal environments. Herein we report an effective approach to stabilize Pd/SiO2 catalysts with porous Al2O3 overlayers coated by atomic layer deposition (ALD) method. 27Al magic angle spinning NMR characterization results show that Al2O3 overlayers on Pd particles coated by ALD method have rich penta-coordinated Al3+ sites capable of strongly interacting with adjacent surface PdOx phases on supported Pd particles. Consequently Al2O3-decorated Pd/SiO2 catalysts exhibit active and stable PdOx and Pd-PdOx structures to efficiently catalyze methane combustion between 200 and 850 °C. These results reveal the unique structural characteristic of Al2O3 overlayers on metal surfaces coated by ALD method and provide a practical strategy to explore stable and efficient supported Pd catalysts for methane combustion.