Miracle-dz/UniFAR-FTUs huggingface dataset:
Exerciseinduced elevations in cerebral blood velocity are greater in running compared to cycling at higher intensities

The optimal exercise intensity and modality for maximizing cerebral blood flow (CBF) and hence potential exposure to positive, hemodynamically derived cerebral adaptations is yet to be fully determined. This study compared CBF velocity responses between running and cycling across a range of exercise intensities. Twenty-six participants (12 females; age:
Systemic Solutions for Addressing Non-Communicable Diseases in Low- and Middle-Income Countries

Abstract Non-communicable diseases (NCDs) have been on the rise in low- and middle-income countries (LMICs) over the last few decades and represent a significant healthcare concern. Over 85% of “premature” deaths worldwide due to NCDs occur in the LMICs. NCDs are an economic burden on these countries, increasing their healthcare expenditure. However, targeting NCDs in LMICs is challenging due to evolving health systems and an emphasis on acute illness. The major issues include limitations with universal health coverage, regulations, funding, distribution and availability of the healthcare workforce, and availability of health data. Experts from across the health sector in LMICs formed a Think Tank to understand and examine the issues, and to offer potential opportunities that may address the rising burden of NCDs in these countries. This review presents the evidence and posits pragmatic solutions to combat NCDs.
The Frail’BESTest. An Adaptation of the “Balance Evaluation System Test” for Frail Older Adults. Description, Internal Consistency and Inter-Rater Reliability

Introduction The Balance Evaluation System Test (BESTest) and the Mini-BESTest were developed to assess the complementary systems that contribute to balance function. These tests include functional tasks involving several high-level exercises to assess the balance function, which may be even more difficult in case of frailty. The Frail’BESTest has been developed to make it possible to include frail older adults in systemic assessment. In this first paper, the objective is to present the Frail’BESTest and to describe the usefulness and complementarity of each system and to test the inter-rater reliability of the score measurements in two health centers. Methods In the first center, 192 frail and non-frail older patients were enrolled to test I) the contribution of each system, II) internal consistency, and III) the threshold and ceiling effects. The scores of 32 patients from center 1 and 32 patients recruited in another center (center 2) were used to measure the inter-rater reliability of the measurements by means of Kendall’s tau coefficients. Results The internal consistency was moderate to good for five systems and limited for “biomechanical constraints”. The distribution of the Frail’BESTest was more centered than that of the Tinetti and Mini-Motor tests. The Kendall’s tau showed strong concordance in center 1 for all systems and only for 4 on 6 systems in center 2. Discussion Completing a systemic evaluation, the therapist may prioritize the patient’s needs identifying the most challenging systems. This paper presents the Frail’BESTest and confirms the psychometric properties at a first step level.
LINC01094 Down-Regulates miR-330-3p and Enhances the Expression of MSI1 to Promote the Progression of Glioma

Background This study aims at probing into the expression, function, and mechanism of LINC01094 and miR-330-3p in glioma. Materials and Methods qRT-PCR was employed to examine LINC01094 and miR-330-3p expressions in gliomas. After gain-of-function and loss-of-function models were constructed, CCK-8 and Transwell assays were used to detect the proliferation, migration and invasion of LN229 and U251 cells, respectively. Additionally, dual luciferase reporter gene assay was utilized to verify the binding site between m4iR-330-3p and LINC01094, miR-330-3p, and the 3ʹUTR of musashi RNA binding protein 1 (MSI1). Then, RNA pull-down, RIP, qRT-PCR and Western blot were employed to detect the regulatory relationships among LINC01094, miR-330-3p, and MSI1. Results The expression of LINC01094 was elevated in glioma tissues and cell lines, and the high expression of LINC01094 was associated with high grade of glioma. In contrast, miR-330-3p was lowly expressed in glioma tissue. Overexpression of LINC01094 or down-regulation of miR-330-3p promoted the proliferation, migration, and invasion of glioma cells, while LINC01094 knockdown or miR-330-3p up-regulation impeded these processes. miR-330-3p was identified as a target miRNA of LINC01094, and it could be negatively regulated by LINC01094. In addition, miR-330-3p antagonized the function of LINC01094 by negatively regulating MSI1. Conclusion LINC01094 promotes the proliferation, migration, and invasion of glioma cells by adsorbing miR-330-3p and up-regulating the expression of MSI1.
Spatial Patterns and Movements in Coprophagous Beetles

Spatial distribution in two groups of dung-inhabiting beetles, Aphodius (Scarabaeidae) and Hydrophilidae, was analysed at two spatial levels, between and within pastures. Long-distance movements in the strictly coprophagous species of Aphodius were studied by trapping beetles in the centre of a town, away from the pastures. In both groups of beetles, and at both spatial levels, a linear relationship was found between log spatial variance and log mean abundance. Between-field variation in numbers was shown to be negatively correlated with the intensity of long-distance movements (interspecific comparison), and between-field variance moreover declined during the seasonal flight period in most species of Aphodius. There was an indication of a negative correlation between spatial variance and the proportion of mature females in the annual catches (Aphodius), which is interpreted as a consequence of interspecific differences in egg-laying habits both in space and time. In species showing little long-distance movements, females predominated among the "migrants" (in the centre of a town), and among the female "migrants" mature individuals were over-represented, compared with the proportion in the pastures. Long-distance movements occurred seasonally in relation to the numbers of beetles in the pastures, which supports the view that in these species there is no important difference between the short-distance and long-distance movements. Modelling of processes important in the dynamics of spatial patterns is discussed, a simple model is proposed, and the advocated universality of the model by Taylor and Taylor is questioned.
Does Work Stressors Lead to Abusive Supervision? A Study of Differentiated Effects of Challenge and Hindrance Stressors

Purpose From the perspective of affective events theory, the present study examines whether two distinct categories stressors (challenge-hindrance stressors) have different effects (hindrance or promotion) on abusive supervision. Materials and Methods The data of 203 pairs of supervisor–subordinate have been collected from 12 different Chinese enterprises.We first conducted confirmatory factor analyses (CFA) in Lisrel software to test the model’s validity. And then, we used the descriptive statistics to example the correlations of variables. Finally, we conducted hierarchical regression analysis and bootstrap methods to test hypotheses. Results The finding shows that two distinct categories stressors have different indirect effects (hindrance or promotion) on abusive supervision. Specifically, challenge stressors reduce abusive supervision through positive affective experience, while hindrance stressors increase abusive supervision through negative affective experience. In addition, locus of control plays a first-stage moderated-mediation role in the indirect effect of challenge stressors on abusive supervision and in the indirect effect of hindrance stressors on abusive supervision. Conclusion This study offers some comprehensive insights for why and when challenge stressors and hindrance stressors have different effects on abusive supervision. This study extends the current literature by directly testing two different underlying psychological mechanisms (resource acquisition and resource depletion), which are responsible for the different effects of challenge stressors and hindrance stressors. Also, individuals’ cognitive attribution tendency is confirmed as boundary conditions of the direct effect of work stressors on affective experience and indirect effects of work stressors on abusive supervision.
Purification of Immunoglobulin Y (IgY) from the Ostrich (Struthio camelus) by Staphylococcal Protein a (Spa) Affinity Chromatography

Immunoglobulin Y (IgY) is the major protein present in the avian egg yolk. This antibody fulfils important functions in the protection of Ostrich birds against infections. The aim of this study was to demonstrate the binding capacity of Staphylococcal proteins A (SpA) to Ostrich IgY and assess purification of the IgY by SpA affinity chromatography. Chloroform polyethylene glycol (Polson), affinity chromatography, Enzyme-Linked Immunosorbent Assay (ELISA)and Western blotting methods were used in the process. Results obtained revealed that Ostrich IgY has heavy chain of 70 kDa and light chain of 30 kDa confirming results by Western blot. In addition livetins (egg yolk proteins)were shown in the protein electrophoresis that preceded the Western blot. The binding capacity between SpA and Ostrich IgY is important because SpA can be used as a reagent in immunoassays for antibody detection against microbial agents that usually infect livestocks. This is the first time the use of SpA for purification of Ostrich IgY is being reported in literature.
The Role of Gender in the Importance of Risk Factors for Coronary Artery Disease

Identification of risk factors and their importance in different genders is essential in order to prevent, diagnose, and manage coronary artery disease (CAD) properly. The present study aims to investigate the role of gender in the distribution of different risk factors in ischemic heart disease. This study is a cross-sectional study. More than one thousand (N = 1012) patients referring to the Nuclear Medicine Department in Namazi Hospital, Shiraz, Iran, from March 2017 to March 2018 were studied. The patients' demographic data and their clinical history were collected. The results of the myocardial perfusion scan were recorded and compared between groups. Statistical analysis was implemented by SPSS version 18.0, and P values below 0.05 were considered statistically significant. Out of the 1012 patients participating in this study, 698 (69%) were female and 314 (31%) were male. Ischemic heart disease (IHD) was significantly higher in men compared to women (19.1% versus 14.2%). The higher levels of systolic and diastolic blood pressures, along with older age, were a significant risk factor in women (P < 0.05). Previous myocardial infarction (MI), diabetes mellitus (DM), hypertension (HTN), and hyperlipidemia (HLP) had a strong correlation with IHD in our female population. Regarding the male subjects, previous MI and HLP had a lower correlation with IHD. Based on our logistic regression models, investigation of the simultaneous effects of risk factors on IHD showed that previous MI is the most effective risk factor in females (OR = 3.93) mostly in terms of residual ischemia in the infarcted myocardium. In the male population, on the other hand, HTN was identified as the most effective risk factor for IHD (OR = 2). In conclusion, we found that older age, higher blood pressure, DM, previous MI, HTN, and HLP have a significant association with IHD in the female population, whereas older age, DM, and HTN were significant risk factors for IHD in males. Also, the most effective factor for women was previous MI, while it was HTN for the male population.
Real-Time Long Range Trajectory Replanning for MAVs in the Presence of Dynamic Obstacles

Real-time long-range local planning is a challenging task, especially in the presence of dynamics obstacles. We propose a complete system which is capable of performing the local replanning in real-time. Desired trajectory is needed in the system initialization phase; system starts initializing sub-components of the system including point cloud processor, trajectory estimator and planner. Afterwards, the multi-rotary aerial vehicle starts moving on the given trajectory. When it detects obstacles, it replans the trajectory from the current pose to pre-defined distance incorporating the desired trajectory. Point cloud processor is employed to identify the closest obstacles around the vehicle. For replanning, Rapidly-exploring Random Trees (RRT*) is used with two modifications which allow planning the trajectory in milliseconds scales. Once we replanned the desired path, velocity components(x,y and z) and yaw rate are calculated. Those values are sent to the controller at a constant frequency to maneuver the vehicle autonomously. Finally, we have evaluated each of the components separately and tested the complete system in the simulated and real environments.
The Long-Acting D3 Partial Agonist MC-25-41 Attenuates Motivation for Cocaine in Sprague-Dawley Rats

The dopamine D3 receptor is a prime target for developing treatments for cocaine use disorders (CUDs). In this study, we conducted a pre-clinical investigation of the therapeutic potential of a long-acting, D3 receptor partial agonist, MC-25-41. Male rats were pre-treated with MC-25-41 (vehicle, 1.0, 3.0, 5.6, or 10 mg/kg, intraperitoneal (IP)) five minutes prior to tests of cocaine or sucrose intake on either a progressive ratio schedule of reinforcement or a variable interval 60 s multiple schedule consisting of 4, 15-min components with sucrose or cocaine available in alternating components. A separate cohort of rats was tested on a within-session, dose-reduction procedure to determine the effects of MC-25-41 on demand for cocaine using a behavioral economics analysis. Finally, rats were tested for effects of MC-25-41 on spontaneous and cocaine-induced locomotion. MC-25-41 failed to alter locomotion, but reduced reinforcement rates for both cocaine and sucrose on the low-effort, multiple schedule. However, on the higher-effort, progressive ratio schedule of cocaine reinforcement, MC-25-41 reduced infusions, and active lever presses at doses that did not alter sucrose intake. The behavioral economics analysis showed that MC-25-41 also increased cocaine demand elasticity compared to vehicle, indicating a reduction in consumption as price increases. Together, these results suggest that similar to other D3-selective antagonists and partial agonists, MC-25-41 reduces motivation for cocaine under conditions of high cost but has the added advantage of a long half-life (>10 h). These findings suggest that MC-25-41 may be a suitable pre-clinical lead compound for development of medications to treat CUDs.
Multivariate Counterfactual Systems and Causal Graphical Models

Among Judea Pearl's many contributions to Causality and Statistics, the graphical d-separation} criterion, the do-calculus and the mediation formula stand out. In this chapter we show that d-separation} provides direct insight into an earlier causal model originally described in terms of potential outcomes and event trees. In turn, the resulting synthesis leads to a simplification of the do-calculus that clarifies and separates the underlying concepts, and a simple counterfactual formulation of a complete identification algorithm in causal models with hidden variables.
Nurses’ Attitudes and Knowledge of Peripherally Inserted Central Catheter Maintenance in Primary Hospitals in China: A Cross-Sectional Survey

Background and Aim The promotion of peripherally inserted central catheter (PICC) maintenance in primary hospitals can benefit discharged patients with PICCs living in remote areas a lot. Yet, no primary hospitals had introduced PICC maintenance technology in Hunan province, China. The present study aimed to evaluate nurses’ attitudes and knowledge of PICC maintenance in primary hospitals in Hunan province, China. Materials and Methods From November 2018 to January 2019, a total of 560 nurses from 28 community hospitals and 28 township hospitals in 14 cities across Hunan were recruited in the present study. All nurses were registered nurses engaged in clinical work related to intravenous infusion, and their attitudes and knowledge of PICC maintenance were measured by a self-designed questionnaire that was based on literature review and expert consultation. Results The response rate was 93.6% (560 of 598). Almost all participants could realize the importance and necessity of PICC maintenance. More than 90% of the participants expressed interest in PICC maintenance and showed strong demands for relevant training. However, the nurses’ correct response rate of most knowledge items was at a low level (7.14–57.68%), with only three items exhibiting the correct response rate of 90% or higher. The factors influencing the nurses’ PICC maintenance knowledge included their nursing experience, professional title, work setting, and department. Conclusion Although nurses in primary hospitals had a positive attitude toward PICC maintenance, their knowledge level was unsatisfactory, which might be a barrier to the promotion of PICC maintenance technology in primary hospitals in Hunan province, China. Multiple parties should get involved and take measures to improve the nurses’ PICC maintenance knowledge, including the government, nursing associations, large-scale hospitals, and primary hospitals themselves. Besides, new training models and dynamic assessment methods should be explored to improve training effectiveness in the future.
Analysis of Key Genes Regulating the Warburg Effect in Patients with Gastrointestinal Cancers and Selective Inhibition of This Metabolic Pathway in Liver Cancer Cells

Objective The Warburg effect, also known as aerobic glycolysis, plays a dominant role in the development of gastrointestinal (GI) cancers. In this study, we analyzed the expression of key genes involved in the Warburg effect in GI cancers and investigated the effect of suppressing the Warburg effect in vitro in liver cancer cell lines. Methods The Cancer Genome Atlas (TCGA) RNA-Seq data were used to determine gene expression levels, which were analyzed with GraphPad Prism 7.00. Genetic alterations were queried with cBioPortal. The influence of the Warburg effect on liver cancer cell viability, migration and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity was determined by means of MTT, transwell and GAPDH activity assays. Results The levels of expression of genes associated with the Warburg effect were increased in tumors. To our knowledge, this is the first report of upregulated expression of CUEDC2, HMGB2, PFKFB4, PFKP and SIX1 in liver cancer. Clinically, overexpression of these genes was associated with significantly worse overall survival of liver cancer patients. In vitro, selective inhibition of GADPH suppressed the growth and metastasis of Huh-7, Bel7404 and Hep3B hepatocellular carcinoma cell lines. Conclusion The Warburg effect may play an important role in GI cancers, especially in liver cancer.
Docetaxel-Loaded Cholesterol-PEG Co-Modified Poly (n-Butyl) Cyanoacrylate Nanoparticles for Antitumor Drug Pulmonary Delivery: Preparation, Characterization, and in vivo Evaluation

Background and Aim Polymeric nanoparticles (NPs) have received much attention as promising carrier systems in lung cancer and brain metastases. Methods Here, for the first time, we investigated the feasibility of using inhaled cholesterol-PEG co-modified poly (n-butyl) cyanoacrylate NPs (CLS-PEG NPs) of docetaxel (DTX) for sustained pulmonary drug delivery in cancer metastasis. Results Spray-dried or freeze-dried NPs yielded sustained drug release in vitro. In vitro inhalation evaluation data indicated that the inhalation formulation had better inhalability. Compared with intravenous (IV) administration, pharmacokinetic data suggested that the inhalation formulation prolonged plasma concentration of DTX for greater than 24 h and is more quickly and completely absorbed into the rat lung after intratracheal (IT) administration. Furthermore, freeze-dried powders were found to increase the t1/2 and area under curve (AUC) by 2.3 and 6.5 fold compared to the free drug after IT administration, and spray-dried powders were found to increase the t1/2 and AUC by 3.4 and 8.8 fold, respectively. After pulmonary administration of the inhalation formulation, DTX appeared to prolong the pulmonary absorption time. In addition, the inhalation formulation was distributed to the brain in a sustained release manner. Conclusion These experimental results demonstrated that freeze- and spray-dried powders have the potential for pulmonary sustained release, and they also have the potential to be used as a novel treatment for the delivery of drugs that pass through the air–blood barrier and enter the brain and are efficient carriers for the treatment of brain metastasis.
Warmth and Competence to Predict Human Preference of Robot Behavior in Physical Human-Robot Interaction

A solid methodology to understand human perception and preferences in human-robot interaction (HRI) is crucial in designing real-world HRI. Social cognition posits that the dimensions Warmth and Competence are central and universal dimensions characterizing other humans [1]. The Robotic Social Attribute Scale (RoSAS) proposes items for those dimensions suitable for HRI and validated them in a visual observation study. In this paper we complement the validation by showing the usability of these dimensions in a behavior based, physical HRI study with a fully autonomous robot. We compare the findings with the popular Godspeed dimensions Animacy, Anthropomorphism, Likeability, Perceived Intelligence and Perceived Safety. We found that Warmth and Competence, among all RoSAS and Godspeed dimensions, are the most important predictors for human preferences between different robot behaviors. This predictive power holds even when there is no clear consensus preference or significant factor difference between conditions.
The Accuracy of Three-Dimensional Planned Bone Tumor Resection Using Patient-Specific Instrument

Introduction Although treatment of bone tumors is multidisciplinary, the complete surgical resection of bone tumors remains the mainstay of the treatment. Patient-specific instruments (PSI) are personalized tools, which help the surgeon to perform tumor resections accurately. The aim of this study is to evaluate how precise the planned resection can be intraoperatively executed with the use of PSI. Patients and Methods Eleven patients who underwent a resection of bone tumor using PSI were analyzed. A preoperative model of the tumor and the affected bone was created from acquired CT scans and MRI. After defining the resection planes, PSI were produced by a 3D printer. The resected piece of bone was scanned and imported in the original planning model enabling the assessment of the distance between the planned resection plane and the realized osteotomy in every direction. Results In overall, the combined error of an osteotomy ranges from 0.74 ± 0.96 mm to 3.60 ± 2.46 mm. The average errors observed in situations with one resection plane (simple osteotomy) are lower than in complex curved osteotomies with multiple planes, in which we also found a greater variance. Conclusion 3D planned bone tumor resections using PSI show promising results for precise resection at different anatomical regions. Even if the found error range in this series is slightly higher than reported, PSI remain a valuable tool to facilitate complex bone tumor resections.