Miracle-dz/UniFAR-FTUs huggingface dataset:
Automation comes to the printing and publishing industry Production and distribution of magazines, periodicals, and books

Existing information retrieval systems, hardware and software for automated publication, and newly developed press and bindery equipment* are the precursors of ever more dramatic and sophisticated systems now in the R&D stages. For example, a fully automated web offset press could be in commercial production within the next few years. At the same time, there is a quiet revolution in bookbinding, based upon plastics technology, that is rendering obsolete conventional binding methods. The day is not far distant when almost completely automatic satellite plants will be operated for producing and distributing periodicals, indexes, catalogs, and books.
Synthesis of Tchebycheff Parameter Symmetrical Filters

This paper consists of two parts. The first part is tutorial and describes at an elementary level one of the contributions made by Darlington. This is the design theory of electrically symmetrical reactive (lossless) networks with particular attention to filters which exhibit Tchebycheff type performance in the pass and stop bands. The second part of the paper is the presentation, in "handbook" style, of step-by-step procedures to be followed in the design of filters of the above type. Emphasis is placed on the use of rapidly converging series in the computations in place of elliptic function tables.
An Analogue Computer for the Solution of Linear Simultaneous Equations

Linear simultaneous equations occur frequently in science and in engineering. Their solution by numerical methods is straightforward, but the amount of work required increases rapidly with the number of unknowns. A device is described for the solution of systems of linear simultaneous equations with not more than twelve unknowns. It is an electrical analogue computer which accepts the problem information in digital form from a set of punched cards. This facilitates the preparation, checking, and insertion of the input data and greatly reduces some of the usual liabilities of an analogue device. No special preparation of the problem is required, other than a simple one of scaling the coefficients. Solutions of well-determined problems are easily and rapidly attained and may be refined to any desired accuracy by a simple iteration procedure.
Porphyrin–Gold Nanomaterial for Efficient Drug Delivery to Cancerous Cells

With an aim to overcome multidrug resistance (MDR), nontargeted delivery, and drug toxicity, we developed a new nanochemotherapeutic system with tetrasodium salt of meso-tetrakis(4-sulfonatophenyl)porphyrin (TPPS) armored on gold nanoparticles (TPPS-AuNPs). The nanocarrier is able to be selectively internalized within tumor cells than in normal cells followed by endocytosis and therefore delivers the antitumor drug doxorubicin (DOX) particularly to the nucleus of diseased cells. The embedment of TPPS on the gold nanosurface provides excellent stability and biocompatibility to the nanoparticles. Porphyrin interacts with the gold nanosurface through the coordination interaction between gold and pyrrolic nitrogen atoms of the porphyrin and forms a strong association complex. DOX-loaded nanocomposite (DOX@TPPS-AuNPs) demonstrated enhanced cellular uptake with significantly reduced drug efflux in MDR brain cancer cells, thereby increasing the retention time of the drug within tumor cells. It exhibited about 9 times greater potency for cellular apoptosis via triggered release commenced by acidic pH. DOX has been successfully loaded on the porphyrin-modified gold nanosurface noncovalently with high encapsulation efficacy (∼90%) and tightly associated under normal physiological conditions but capable of releasing ∼81% of drug in a low-pH environment. Subsequently, DOX-loaded TPPS-AuNPs exhibited higher inhibition of cellular metastasis, invasion, and angiogenesis, suggesting that TPPS-modified AuNPs could improve the therapeutic efficacy of the drug molecule. Unlike free DOX, drug-loaded TPPS-AuNPs did not show toxicity toward normal cells. Therefore, higher drug encapsulation efficacy with selective targeting potential and acidic-pH-mediated intracellular release of DOX at the nucleus make TPPS-AuNPs a “magic bullet” for implication in nanomedicine.
A zero DC-power low-distortion mixer for wireless applications

A fully integrated passive field-effect transistor (FET) mixer with a measured conversion loss of 7 dB and a -1 dB input compression point of -1.5 dBm at 1.9 GHz was fabricated in a standard 0.6 μm GaAs MESFET process. Zero DC-power consumption, excellent dynamic performance, and low loss make this circuit very suitable for low-power low-voltage wireless applications.
Applied Business Research

An enterprise, financially oriented or otherwise, needs managers and management scientists. Persons with differing skills, attitudes, and incentive reward systems fulfill these two roles respectively. The manager is identified as a single individual and the management scientist as a team. The ``traditional'' approach of identifying the differences in the two classifications is presented. A method of selecting problems is described that appears to be meaningful to both the manager and management scientists and which serves as a basis for research portfolio selection. The usual scheme for allocating research effort between short- and long-range payoffs is analyzed. This single distribution of effort with little real time contribution and little ``way out work'' creates a negative relationship situation, and generates comparatively low payoffs to the enterprise as well as to the managers and management scientists. A second, bi-modal scheme is outlined involving real time help to operating managers by management scientists, a significant ``way out'' contribution, and an area of cooperative work. This scheme seems to generate a positive atmosphere of mutual respect, interdependence, and cooperative action. This approach takes the same personal and professional differences as the first approach, but uses them to their mutual advantage rather than as points of conflict. An attempt is made to suggest a general hypothesis for cooperative team business research wherein the line manager is a participating member of the research group.
Central Corneal Edema with Scleral-Lens Wear

ABSTRACT Purpose: To evaluate the safety of scleral-lens designs, we model and clinically assess central corneal edema induced by scleral-lens wear for healthy subjects. Materials and Methods: Central corneal swelling during scleral-lens wear is measured using optical coherence tomography (OCT). Transport resistances are modeled for oxygen diffusion through the scleral lens and post-lens tear-film (PoLTF), and into the cornea. Oxygen deficiency in the cornea activates anaerobic metabolic reactions that induce corneal edema. Oxygen permeability, carbon-dioxide permeability, settled-lens PoLTF thickness, and scleral-lens thickness are varied in the calculations to mimic different lens fits. Results: Transport modeling predicts that for open eyes, increasing PoLTF thickness from 50 to 400 µm increases central corneal swelling by approximately 1–1.5% when oxygen transmissibility (Dk/L) is greater than 10 hBarrer/cm (i.e., hectoBarrer/cm). Although swelling is larger for oxygen Dk/L < 10 hBarrer/cm, PoLTF thickness has minimal impact in this range. For open eye, oxygen transmissibility of the lens plays a significant role in corneal edema, but is negligible when oxygen Dk/L is > 40 hBarrer/cm. For closed eye, central corneal swelling is greater than 5% for an oxygen Dk/L range of 0–100 hBarrer/cm with typical lens-fitting parameters. For carbon-dioxide transmissibilities increasing from 50 to 250 hBarrer/cm and with a fixed oxygen Dk/L of 25 hBarrer/cm, calculated swelling diminishes by an additional 0.5%. Comparison of model calculations to clinical-swelling data is within the error range of the clinical measurements. Conclusions: Oxygen/metabolite transport calculations for open-eye scleral-lens wear show that typical PoLTF thicknesses fitted by clinicians (i.e., PoLTF thicknesses < 400 µm) with modern scleral lenses (i.e., oxygen Dk/L > 25 hBarrer/cm) produce corneal swelling of less than 2% in agreement with experiment. Therefore, scleral lenses prescribed today evoke less than physiological hypoxic swelling (i.e., less than 4%) for healthy corneas during open-eye. Closed-eye wear, however, appears clinically unsafe.
Impedance of thin-wire loop antennas

THE THIN-wire loop is one of the first antennas to receive theoretical consideration, having been discussed by Pocklington1 in 1897. Pocklington treated a closed loop excited by a plane wave; he obtained an exact solution for the current on the loop in the form of a Fourier series. More recently, Hallén2 considered a driven loop and obtained a solution, again in the form of a Fourier series, for the current and the impedance. However, Hallén pointed out that the coefficients of this series contained a singularity which made the series only quasiconvergent and hence useful only for loops small in comparison to a wave length. Moreover, the individual terms were complicated and their evaluation and a summation involved a somewhat difficult numerical task.
Optimum Reception in an Impulsive Interference Environment - Part I: Coherent Detection

Because communications systems are seldom significantly interfered with by classical white Gaussian noise, it is necessary to consider other, appropriate (and tractable) interference models, if realistic estimates of system performance are to be obtained for the general spectral-use environment. For this purpose, Middleton's recently developed canonical statistical-physical model of "impulsive" interference is applied to real-world communication channels. The principal features of this model are first summarized, including the statistical relations required for the solution of signal detection problems. [Excellent agreement of these model statistics with correspondingly measured statistics is also noted. ] The model for narrow-band impulsive interference (Class A noise, a subset of the overall model) is next specifically applied to an important class of coherent signal detection problems. Algorithms for error probabilities in optimum detection are then obtained, along with performance bounds, for the same error probabilities. Since it is known that in order to gain significant improvement over current receivers, the number of (essentially) independent samples of the received interference waveform must be enlarged (i.e., large "processing gains"), the performance results here are given parametrically in the number of samples, or equivalently, in the time-bandwidth product. Performance of current suboptimum receivers is then obtained and compared to the optimum performance. It is shown that very substantial savings in signal power and/or spectrum space can usually be achieved by using the indicated optimal algorithms. Since physical realization of the completely optimum detection algorithms cannot, in general, be economically realized, the somewhat more conservative, corresponding locally optimum Bayes detection (LOBD) receivers are derived. In general, these LOBD structures require adaptive, highly non-linear filters, preceding the conventional correlation detector elements characteristic of optimum receivers for Gaussian interference. Performance for these non-linear, optimum threshold systems is then determined, specifically in Part I for coherent reception.
Image Suppression in Superheterodyne Receivers

Superheterodyne receivers are particularly sensitive to interference at the intermediate frequency and at the image frequency. Several types of selective circuits are described for coupling the antenna to the grid of the first tube which have especially great selectivity against such interference. The number of selective circuits which must be tuned to the signal is thereby minimized. Performance curves are given for receivers having intermediate frequencies of 175 or 450 kilocycles.
Oogenesis is accompanied by cyclic morphological changes in hepatocytes of Neotropical freshwater fish Piabina argentea

We determined for the first time the reproductive biology of Piabina argentea through macroscopic and microscopic analysis of ovaries and evaluated the morphological changes in hepatocytes. Two hundred and 46 specimens were collected, 204 females and 42 males, between March 2014 and February 2015. Biometrics data were obtained. From females, gonad and liver samples were conducted to histological, histochemical and immunohistochemical techniques. Mature ovaries were used to determine absolute and relative fecundity. Total length and body weight values indicated that females were larger than males. The estimated weight–length ratio showed negative allometric growth. The absolute fecundity average was 171.83 ± 59.89 oocytes per ovary. In addition, females spawning capable and regressing stages were found throughout the sampling period and the presence of all oocyte types in regressing stage ovaries indicated asynchronous oocyte development and multiple spawning. From regenerating to spawning capable stage the oocytes accumulated yolk in cytoplasm became bigger. While in the liver hepatocytes with a larger cell area during regenerating stage and proliferative activity in the spawning capable stage were observed. Thus, our results indicate that P. argentea had an opportunistic reproductive strategy and cyclic morphological changes of hepatocytes occurred during the oogenesis.
Sexual steroid hormone receptors profiles of ovarian carcinoma in Mexican women

The significance of the presence of androgen receptor (AR), estrogen receptor alpha (ER) and progesterone receptor (PR) in ovarian cancer patient survival has been a matter of numerous studies. This study was aimed to describe the expression profile of the three sexual steroid receptors in high-grade serous, endometrioid, mucinous and low-grade serous ovarian carcinoma and its association to the proliferation index in patients with primary ovarian carcinoma diagnosis, before any treatment. Eighty-one samples were obtained from the National Institute of Cancerology in Mexico City and were evaluated for the presence of AR, ER, PR and Ki67 by immunohistochemistry. The four subtypes of ovarian carcinoma displays a specific profile of the eight possible combinations of the steroid receptors with significant differences within the profile and the histological subtypes. High-grade serous carcinoma was characterized by a high frequency of both, triple-negative and AR+ ER− PR+ profiles. Endometrioid carcinoma presented a higher frequency of triple-positive profile. The presence of only AR+ profile was not observed in the endometrioid tumors. The relationship of the receptor profile with the proliferation index in the tumor epithelium shows that the expression of only ER is associated to a reduced proliferation index in endometrioid carcinoma. Steroid hormone receptor expression and co-expression could help characterize ovarian carcinoma.
Relationship Between White Matter Abnormalities and Neuropsychological Measures in Children With ADHD

Objective: Using Diffusion Tensor Imaging (DTI), to investigate microstructural white matter differences between ADHD and typically developing children (TDC), and their association with inhibition and working memory performance usually impaired in ADHD. Method: Fractional anisotropy (FA) and mean diffusivity (MD) were estimated in 36 noncomorbid children with a Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.; DSM-IV-TR) diagnosis of combined type ADHD and 20 TDC. Correlations between FA/MD and Stop Signal Task and N-Back performance parameters were computed. Results: Working memory performance was significantly associated with MD in the superior longitudinal fasciculus (SLF) and the cingulum in the ADHD group. No between-group differences in FA/MD reached significance, after controlling for between-group head motion differences. Conclusion: The association between white matter integrity in the cingulum and the SLF and working memory performance confirms previous studies. Our results also show that when critical conditions are controlled (age, comorbidity, head motion), no ADHD-related structural abnormality (FA/MD) are observed, in line with prior suggestions.
Orientation of Laurdan in Phospholipid Bilayers Influences Its Fluorescence: Quantum Mechanics and Classical Molecular Dynamics Study †

Fluidity of lipid membranes is known to play an important role in the functioning of living organisms. The fluorescent probe Laurdan embedded in a lipid membrane is typically used to assess the fluidity state of lipid bilayers by utilizing the sensitivity of Laurdan emission to the properties of its lipid environment. In particular, Laurdan fluorescence is sensitive to gel vs liquid–crystalline phases of lipids, which is demonstrated in different emission of the dye in these two phases. Still, the exact mechanism of the environment effects on Laurdan emission is not understood. Herein, we utilize dipalmitoylphosphatidylcholine (DPPC) and dioleoylphosphatidylcholine (DOPC) lipid bilayers, which at room temperature represent gel and liquid–crystalline phases, respectively. We simulate absorption and emission spectra of Laurdan in both DOPC and DPPC bilayers with quantum chemical and classical molecular dynamics methods. We demonstrate that Laurdan is incorporated in heterogeneous fashion in both DOPC and DPPC bilayers, and that its fluorescence depends on the details of this embedding.
Hippotherapy in adults with acquired brain injury: A systematic review

ABSTRACT Background Hippotherapy is used to supplement conventional therapy in neurological conditions with evidence supporting its use in pediatric patients. However, evaluation of its merit in adults with acquired brain injury (ABI) is lacking. The aim of this study was to determine if hippotherapy can improve motor function in adults with ABI. Methods: A systematic review of all available controlled studies investigating the use of hippotherapy, in adults with ABI, was conducted. The primary outcome of interest was movement related function and secondary outcomes included impairment, quality of life, and adverse events. Results: Nine studies with 256 participants were included, of which six studies with 204 participants were included for meta-analysis. When the data were pooled, hippotherapy did not produce statistically significant improvements in balance (SMD = 0.24, 95% CI −0.05, 0.54, p = 0.1) or gait parameters (SMD = −0.04, 95% CI −0.79, 0.72 p = 0.92) when compared to control and measured immediately after the intervention. Long-term effects remain unknown due to lack of follow-up evaluation. Conclusions: This review suggests that hippotherapy is safe and well tolerated by adults with ABI. Short-term functional benefits were not associated with the use of hippotherapy. Further high-quality research is required before hippotherapy can be endorsed as a modality in adult neurological rehabilitation.
Intrasystem transmission losses

THIS paper describes a new method of calculating transmission losses within power systems. Reasonable accuracy is obtained with longhand calculation, although the same general scheme with the load-flow determinations carried out on a d-c calculating board would provide greater accuracy with less work. The use of an a-c calculating board with separate tabulations of kilowatt and kilovar flows would be even more advantageous. The method is based on the principle of superimposing the load distribution from each source, determining the current in each line as a sum of the individual load flows (with each in its proper direction), squaring this expression for current, and setting up an equation for losses in terms of megawatt generation at the various plants and of megawatt flows (in or out) at each interchange point. An outward flow of power at an interchange point is considered negative generation.
Effect of Supplementation of a Whey Peptide Rich in Tryptophan-Tyrosine-Related Peptides on Cognitive Performance in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study

Background: Previous epidemiological and clinical studies have shown that dairy products have beneficial effects on cognitive decline and dementia. Enzymatic digestion of whey protein produces a whey peptide rich in tryptophan-tyrosine-related peptides which improve cognitive performance in mice. We evaluated the effects of whey peptides on cognitive functions in healthy adults in a randomized, double-blind, placebo-controlled design. Methods: 101 healthy adults (45 to 64 years), with a self-awareness of cognitive decline received either whey peptide or placebo supplements for 12 weeks. Changes in cognitive function were assessed using neuropsychological tests at 6 and 12 weeks after the start of supplementation. Results: Verbal fluency test (VFT) score changes tended to be higher in the whey peptide group compared with the placebo at 12 weeks. Subgroup analysis classified by the degree of subjective fatigue showed that changes in the VFT as well as the Stroop and subjective memory function tests between baseline and 6 weeks of intervention were significantly better in subjects with high-level fatigue from the whey peptide group as compared to the placebo group. Conclusions: Intake of whey peptide might improve cognitive function in healthy middle- and older-aged adults with high subjective fatigue levels. Further studies will elucidate the relationship among cognitive improvement, whey peptides, and psychological fatigue.
Evaporation-induced foam stabilization in lubricating oils

Significance Mitigating lubricant foaming is of primary concern to lubricant manufacturers, as the control of deleterious foams is critical in high-performance applications. Facilitating the development of techniques to control foaming, the results from this research has identified that a special type of Marangoni flow driven by the differential evaporation of lubricant components plays a central role in promoting foaming in lubricant base oils. In addition, this research also shows that analyzing the stability of single bubbles can complement the foam stability data obtained from traditional bulk foam experiments. Hence, this paper provides physical insights into lubricant foaming and describes a convenient platform that lubricant manufacturers can use to develop better lubricants that are not susceptible to foaming. Foaming in liquids is ubiquitous in nature. Whereas the mechanism of foaming in aqueous systems has been thoroughly studied, nonaqueous systems have not enjoyed the same level of examination. Here we study the mechanism of foaming in a widely used class of nonaqueous liquids: lubricant base oils. Using a newly developed experimental technique, we show that the stability of lubricant foams can be evaluated at the level of single bubbles. The results obtained with this single-bubble technique indicate that solutocapillary flows are central to lubricant foam stabilization. These solutocapillary flows are shown to originate from the differential evaporation of multicomponent lubricants—an unexpected result given the low volatility of nonaqueous liquids. Further, we show that mixing of some combinations of different lubricant base oils, a common practice in the industry, exacerbates solutocapillary flows and hence leads to increased foaming.