Miracle-dz/UniFAR-FTUs huggingface dataset:
Personal information management on social media from the perspective of platform support: a text analysis based on the Chinese social media platform policy

PurposeIn this study, specific measures adopted by the social media platforms in China supporting personal information management are investigated via surveys targeting such platforms. The purpose of this paper is to find out how social media platforms understand information management, and from which aspects and through what specific methods they provide support for information management, which contributes to understanding the issues and strategies associated with personal information management on social media.Design/methodology/approachThe dimensions and specific contents of the current platform support provided for information management are clearly defined by performing qualitative text analysis based on the content obtained from 11 platform policies published by five representative Chinese social media platforms.FindingsHow social media platforms support personal information management on creation, collection, utilisation, sharing, storage, protection, removal and modification is identified. By analysing the status quo of support provided by the Chinese social media platform, some issues are proposed for discussion. Improved normative management is required to address the coexistence of multivalued information and management risks. However, the user rights are limited because the platform policies tend to be more focused on the perspective of the social media platform. Furthermore, the platform policy contents regarding information management are incomplete, and the applicability of these policies should be improved.Originality/valueThis study seeks to contribute to personal information management on social media from the perspective of platform support. The perspective from the platforms as the service providers supporting information management also helps identify information management challenges and potential strategies. Furthermore, combining with the personal information management perspective, this study provides a background understanding of information management under a social collaborative framework for platforms, authorities, users and memory institutions.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/OIR-06-2020-0249
Novel Vorinostat Analogues with Improved HDAC Inhibition, Stronger Cytotoxic Effect and Higher Selectivity Against Leukemias and Lymphomas

Histone deacetylase (HDAC) inhibitors are class of drugs used in the cancer treatment. Here, we developed a library of 19 analogues of Vorinostat, an HDAC inhibitor used in lymphomas treatment. In Vorinostat, we replaced the hydrophobic phenyl group with various tricyclic ‘caps’ possessing a central, eight-membered, heterocyclic ring, and investigated the HDAC activity and cytotoxic effect on the cancer and normal cell lines. We found that three out of the 19 compounds, based on dibenzo[b,f]azocin-6(5H)-one, 11,12-dihydrodibenzo[b,f]azocin-6(5H)-one and benzo[b]naphtho[2,3-f][1,5]diazocine-6,14(5H,13H)-dione scaffolds, showed better HDACs inhibition than the referenced Vorinostat. In leukemic cell line MV4-11 and in lymphoma cell line – Daudi three compounds showed lower IC50 values than Vorinostat. These compounds had higher activity and selectivity against MV4-11 and Daudi cell lines than reference Vorinostat. We also observed a strong correlation between HDACs inhibition and the cytotoxic effect. Cell lines derived from solid tumors: A549 (lung carcinoma) and MCF-7 (breast adenocarcinoma) as well as reference Balb/3T3 (normal murine fibroblasts) were less susceptible to compounds tested. Developed derivatives show superior properties than Vorinostat, thus they are applicable as selective agents for leukemia and lymphoma treatment.
Enhanced polyphenol content and antioxidant capacity in the edible portion of avocado dried with superheated-steam

In order toevaluatethe effects of drying methods on assay, this present study investigated the effect of superheated-steam drying at three different temperatures (130°C, 150°C and 170°C), in comparison with freeze drying on phenolic and flavonoid contents as well as antioxidant capacities in avocado ( Persea americana Mill) pulp. The results showed that superheated-steam dried (SHSD) avocado pulp gave significantly higher total phenolic and total flavonoid contents compared to its freeze dried (FD) counterpart. The IC 50 values from the DPPH assay were significantly lower (higher antioxidant activity)in SHSD pulp at all the temperatures used (6.69 – 12.16 mg/ml) compared to FD (35.02 mg/ml). The ORAC values also showed significantly higher radical absorbing capacitywhen SHSD at 170°C (26.58 µmol TE/1g)compared to FD (15.18 µmol TE/1g). The results showed that the drying methods significantly increased antioxidant capacity of SHSD avocado pulp in comparison with the FD.Superheated-steam drying at 170°C is proposed as an appropriate drying technique and condition to preserve pulp in avocado. pulp dried using freeze dryer and superheated-steam dryer (steam temperature of 130°C, 150°C and 170°C). In this study, the pulp showed the lowest TPC value when FD (520.55 mg GAE/100g dried sample). When SHSD, the high temperature ofthe superheated-steam applied in the drying process seemed to give a positive effect to the TPC in the pulp of avocado, where the TPC valueswere significantly higher at all three different temperatures (735.06 - 934.61 mg GAE/100g dried sample) compared to its FD counterpart. The TPC value in SHSD pulp increased with the increase in temperature, where the highest TPC was observed at the steam temperature of 170°C. The TPC values from this finding still shows higher TPC values in both SHSD and FD pulp compared to a study conducted on fresh pulp of avocado (Wolfe et al., 2008), indicating that dried avocado pulp may contain higher total polyphenols compared to the fresh ones. antioxidant activities were enhanced when avocado pulp was dried with superheated-steam. The results showed that the polyphenols contents as well as antioxidant activities in avocado significantly increased during SHSD in comparison with FD. The presented results in this work strongly suggest that superheated-steam drying is a preferred drying method for avocado pulp as it enhanced its polyphenol contents and antioxidant activities. Unfortunately, very little is known about how antioxidant capacity correlates with the number of phenoliccompounds or the type of antioxidant found before and after SHSD.The increase inthe range of applications for superheated steam technology would encourage the growth of this area of research. Thepolyphenol contents in SHSD avocado pulp shallbe elucidated in upcomingstudies.In near future, we hope to identify the key antioxidant determinants by analysis of thermally degradablecomponents in avocado on these work characteristics.
The Effect of Endurance, Eye-Hand Coordination, and Confidence to Volleyball Referee Performance in West Java

A sports competition is a measure of success for an athlete. However, factors affecting an athlete's success come from the athlete and all competition aspects, including referees. Referees need to have a good reputation before and after carrying out their role as court judges. A referee must have competencies, including refereeing skills, rules of the game/competition, physical condition, mental-psychological conditions (self-confidence, calm, consistency, the assertiveness of attitudes and actions, accuracy in weighing and deciding, high motivation, honest & sincere, socializing). Thus, this research aims to examine the effect of physical conditions, primarily components of endurance, eye-hand coordination, and self-confidence, as psychological aspects that strengthen the referee's performance. To achieve this research's objectives, a survey method was used using path analysis and measurement techniques in tests through standard performance evaluation of volleyball referees, confidence questionnaires, 12 minutes running fitness test, and eye-hand coordination. The population involved in this research was 335 referees who had regional and national diplomas. The sample of this research used the Slovin pattern with an error rate of 10%, so that the sample amounted to 77 volleyball referees in West Java. The conclusions of this research are (1) Endurance affects the performance of the referee by 42.9%, (2) Eye-hand coordination affects the performance of the referee by 39.6%, (3) Confidence affects the performance of the referee by 45.8%, (4) Endurance affects self-confidence by 51.2%, (5) Eye-hand coordination affects self-confidence by 40.8%.
Fungal community response to long‐term soil warming with potential implications for soil carbon dynamics

The direction and magnitude of climate warming effects on ecosystem processes such as carbon cycling remain uncertain. Soil fungi are central to these processes due to their roles as decomposers of soil organic matter, as mycorrhizal symbionts, and as determinants of plant diversity. Yet despite their importance to ecosystem functioning, we lack a clear understanding of the long-term response of soil fungal communities to warming. Toward this goal, we characterized soil fungal communities in two replicated soil warming experiments at the Harvard Forest (Petersham, Massachusetts, USA) which had experienced 5 ° C above ambient soil temperatures for 5 and 20 yr at the time of sampling. We assessed fungal diversity and community composition by sequencing the ITS2 region of rDNA using Illumina technology, along with soil C concentrations and chemistry. Three main ﬁ ndings emerged: (1) long-, but not short-term warming resulted in compositional shifts in the soil fungal community, particularly in the saprotrophic and unknown components of the community; (2) soil C concentrations and the total C stored in the organic horizon declined in response to both short- (5 yr) and long-term (20 yr) warming; and (3) following long-term warming, shifts in fungal guild relative abundances were associated with substantial changes in soil organic matter chemistry, particularly the relative abundance of lignin. Taken together, our results suggest that shifts with warming in the relative abundance of fungal functional groups and dominant fungal taxa are related to observed losses in total soil C.
Interaction between carboplatin with B12P12 and Al12P12 nano-clusters: A computational investigation

Abstract This study was conducted to investigate the interaction between B12P12 and Al12P12 nano-clusters with carboplatin complex using wB97XD functional. Two interaction modes between B12P12 and Al12P12 nano-clusters and carboplatin complex were considered. The interaction energy values of these complexes were calculated. Shubin Liu's energy decomposition analysis (EDA-SBL) was used to study the source of energy difference between various isomers of B12P12…carboplatin and Al12P12…carboplatin complexes. The molecular properties related to the biological activity of these drug precursor molecules were studied (octanol–water partition coefficient (log P) and molecular volume (Vm )). Charge transfer between fragments was illustrated through electrophilicity-based charge transfer (ECT). The quantum theory of atoms in molecules (QTAIM) analysis was applied to assess the Pt–B, Pt–Al, and Pt–P bond critical points within these complexes. Graphical Abstract
Prospective Investigation of Postoperative Complications in Anterior Decompression with Fusion for Severe Cervical Ossification of the Posterior Longitudinal Ligament

Supplemental Digital Content is available in the text Study Design. A prospective multicenter study. Objective. This study aims to investigate the postoperative complications of anterior decompression with fusion (ADF) for the treatment of cervical ossification of the posterior longitudinal ligament (OPLL). Summary of Background Data. Surgical treatment for cervical OPLL has a high risk of various complications. ADF is reported to be effective for cervical OPLL, especially for massive OPLL. However, few studies have focused on the surgical complications of ADF. Methods. We prospectively included 102 patients undergoing ADF for severe cervical OPLL with average canal occupying ratio of 49.8%. We evaluated systemic and local complications, neurological complications, and risk factors related to the postoperative complications. Results. Frequently observed complications included graft/ implant complications (18.6%), neurological complications (11.8%), and cerebrospinal fluid leak (11.8%). Motor palsy involving only the upper extremity was found in nine patients (8.8%), and other motor palsies involving the lower extremities were found in three patients (2.9%). None of the preoperative factors were significantly associated with the occurrence of neurological palsies, whereas the number of operated levels was a significant factor related to the postoperative graft/implant complications (P = 0.003; odds ratio, 2.112). The incidence of graft/implant complications and related reoperation increased as the number of operated levels increased (especially four levels or more). Most motor palsies were observed immediately after surgery. Of the motor palsies in the bilateral upper extremities and palsies involving the lower extremities, 85.7% showed good recovery, whereas only 40% of unilateral upper extremity motor palsies showed good recovery during the follow-up period. Conclusion. In ADF for cervical OPLL, the number of operated levels was a significant factor related to the postoperative complication. Specifically, the incidence of graft/implant complications and reoperation rate increased in ADF with four or more levels. Level of Evidence: 3
Sustainable Shift from Centralized to Participatory Higher Education in Post-Soviet Countries: A Systematic Literature Review

Since the fall of the Soviet Union, higher education (HE) in post-Soviet reality continues to face complex challenges, including hierarchical structures, antiquated teaching methods, and lack of international standards. In the meantime, in the US and in Europe, HE has recently focused on participatory curriculum development (PCD) and programs that seek to directly connect student learning to “real-world” problems, accelerating positive change in curricula and through their contributions to regional communities. Accepted into the Bologna Process—the standardization of European HE—Armenian HE institutions struggle to satisfy requirements and related sustainable development goals with centralized standards, inhibiting them from being internationally competitive and regional sustainability change agents. In this article, we examine post-Soviet HE development since 1991 and challenges, with a particular focus on Armenia; what participatory curriculum building may offer; and how it contributes to HE and regional sustainability transitions. A systematic literature review was applied, using specific combinations of important terms restricting the search with criteria such as language, year of publication, and descriptive or critical in nature. The results illustrate the status quo of post-Soviet HE, synthesize current barriers of HE as potential change agents, and highlight PCD as a way to overcome these barriers.
Comparison of the Response to the CXCR4 Antagonist AMD3100 during the Development of Retinal Organoids Derived from ES Cells and Zebrafish Retina

Retinal organoids generated from human embryonic stem cells or iPSCs recreate the key structural and functional features of mammalian retinal tissue in vitro. However, the differences in the development of retinal organoids and normal retina in vivo are not well defined. Thus, in the present study, we analyzed the development of retinal organoids and zebrafish retina after inhibition of CXCR4, a key role in neurogenesis and optic nerve development, with the antagonist AMD3100. Our data indicated that CXCR4 was mainly expressed in ganglion cells in retinal organoids and was rarely expressed in amacrine or photoreceptor cells. AMD3100 treatment reduced the retinal organoid generation ratio, impaired differentiation, and induced morphological changes. Ganglion cells, amacrine cells, and photoreceptors were decreased and abnormal locations were observed in organoids treated with AMD3100. Neuronal axon outgrowth was also damaged in retinal organoids. Similarly, a decrease of ganglion cells, amacrine cells, and photoreceptors and the distribution of neural outgrowth was induced by AMD3100 treatment in zebrafish retina. However, abnormal photoreceptor ensembles induced by AMD3100 treatment in the organoids were not detected in zebrafish retina. Therefore, our study suggests that although retinal organoids might provide a reliable model for reproducing a retinal developmental model, there is a difference between the organoids and the retina in vivo.
Analysis of Customer Satisfaction Service Bike shop AHASS Delima Jaya 1091 Bandung

Research with the title Analysis of Customer Service Bike shop at AHASS Delima Jaya 1091. This study uses the method of observation, interviews, and questionnaires. The data will be analyzed using quantitative descriptive method. SERVQUAL method is a research method that the author uses and analysis which is a research method that aims to collect data describing the state of the object of research and then analyze it so that a conclusion can be drawn in this study in determining the number of sample members.
Employees perceptions of non‐monetary recognition practice and turnover: Does recognition source alignment and contrast matter?

Correspondence Denis Chênevert, Department of HR Management, HEC Montréal, Chemin de la Côte‐Sainte‐Catherine, Montréal, QC H3T 2A7, Canada. Email: denis.chenevert@hec.ca Abstract Nonmonetary recognition originates from various sources (distal and proximal) and research has yet to examine the interplay among them. Results of a 2‐year time‐lagged study (N = 221), employing polynomial regression and response surface analysis, revealed that when distal organisational nonmonetary recognition is aligned with recognition from proximal sources, employees had lower turnover intentions and, indirectly, were less likely to quit 2 years later. For the most part, these relationships do not differ significantly based on the level at which alignment of distal and proximal recognition occurs. In terms of contrasts, when distal recognition exceeds the level of proximal recognition from the supervisor, turnover intentions are higher. For other proximal sources (co‐workers, physicians and patients), turnover intentions were higher irrespective of the type of contrast. This study adds to the strategic HRM literature by showing that contrasts between
BILIARY DISEASE IN PREGNANCY: A DIAGNOSTIC DILEMMA

This is a case report of a 37-year-old female who presented with deranged liver function tests, epigastric pain, fevers, vomiting, mild hypertension, and proteinuria in pregnancy. This was on a background of gestational diabetes, dyspepsia, and previous cholecystectomy. This case report highlights the importance of considering various causes of liver pathology during pregnancy besides those specifically associated with pregnancy, as well as the necessity of early specialist input to investigate symptomatic choledocholithiasis in pregnancy.
Comparison of 10 emerging SARS-CoV-2 Variants: infectivity, animal tropism, and antibody neutralization

Ten emerging SARS-CoV-2 variants—B.1.1.298, B.1.1.7, B.1. 351, P.1, P.2, B.1. 429, B.1. 525, B.1. 526-1, B.1. 526-2, B.1.1.318—and seven corresponding single amino acid mutations in the receptor-binding domain were examined using SARS-CoV-2 pseudovirus. The results indicate that the current SARS-CoV-2 variants do not increase infectivity among humans. The K417N/T, N501Y, or E484K-carrying variants exhibited increased abilities to infect to mouse ACE2-overexpressing cells. The activities of Furin, TMPRSS2, and cathepsin L were increased against most of the variants. RBD amino acid mutations comprising K417T/N, L452R, Y453F, S477N, E484K, and N501Y caused significant immune escape from 11 of 13 monoclonal antibodies. However, the resistance to neutralization by convalescent serum or vaccines was mainly caused by the E484K mutation, while the neutralization of E484K-carrying variants was decreased by 1.1–6.2-fold. The convalescent serum from B.1.1.7- and B.1. 351-infected patients neutralized the variants themselves better than other SARS-CoV-2 variants.
Construction of a prognostic risk model of colorectal adenocarcinoma through integrated analysis of RNA-binding proteins

Background RNA binding proteins (RBPs) play an important role in a variety of cancers. However, their mechanisms in cancer progression are still limited especially in colorectal adenocarcinoma (COAD). Integrated analysis of RBPs will provide a better understanding of disease genesis and new insights into COAD treatment. Methods The gene expression data and corresponding clinical information for COAD were downloaded from The Cancer Genome Atlas (TCGA) database. Univariate Cox regression analysis was used to screen for RBPs associated with COAD recurrence, and multivariate Cox proportional hazards regression analyses were used to identify genes that were associated with COAD recurrence. A nomogram was constructed to predict the recurrence of COAD, and a receiver operating characteristic (ROC) curve analysis was performed to determine the accuracy of the prediction models. The Human Protein Atlas database was used in prediction models to confirm the expression of key genes in COAD patients. Results A total of 177 differentially expressed RBPs was obtained, comprising 123 upregulated and 54 downregulated. GO and KEGG enrichment analysis showed that the differentially expressed RBPs were mainly related to mRNA metabolism, RNA processing and translation regulation. Seven RBP genes (TDRD6, POP1, TDRD7, PPARGC1A, LIN28B, LRRFIP2 and PNLDC1) were identiﬁed as prognosis-associated genes and were used to construct the prognostic model. Conclusions We constructed a COAD prognostic model through bioinformatics analysis and the nomogram can effectively predict the 1-year, 2-year, and 3-year survival rate for COAD patients.
A real-time flow forecasting with deep convolutional generative adversarial network: Application to flooding event in Denmark

Real-time flood forecasting is crucial for supporting emergency responses to inundation-prone regions. Due to uncertainties in the future (e.g., meteorological conditions and model parameter inputs), it is challenging to make accurate forecasts of spatiotemporal floods. In this paper, a real-time predictive deep convolutional generative adversarial network (DCGAN) is developed for flooding forecasting. The proposed methodology consists of a two-stage process: (1) dynamic flow learning and (2) real-time forecasting. In dynamic flow learning, the deep convolutional neural networks are trained to capture the underlying flow patterns of spatiotemporal flow fields. In real-time forecasting, the DCGAN adopts a cascade predictive procedure. The last one-time step-ahead forecast from the DCGAN can act as a new input for the next time step-ahead forecast, which forms a long lead-time forecast in a recursive way. The model capability is assessed using a 100-year return period extreme flood event occurred in Greve, Denmark. The results indicate that the predictive fluid flows from the DCGAN and the high fidelity model are in a good agreement (the correlation coefficient ≥ 97 % and the mean absolute error ≤ 0.008 m) for a lead-900 time step forecast. This is an important step toward real-time flow forecasting although further evaluation of the DCGAN performance is required in complex realistic cases in the future.