Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterizing Polytobacco Use Trajectories and Their Associations With Substance Use and Mental Health Across Mid-Adolescence

Abstract Background Polytobacco product use is suspected to be common, dynamic across time, and increase risk for adverse behavioral outcomes. We statistically modeled characteristic types of polytobacco use trajectories during mid-adolescence and tested their prospective association with substance use and mental health problems. Methods Adolescents (N = 3393) in Los Angeles, CA, were surveyed semiannually from 9th to 11th grade. Past 6-month combustible cigarette, e-cigarette, or hookah use (yes/no) over four assessments were analyzed using parallel growth mixture modeling to identify a parsimonious set of polytobacco use trajectories. A tobacco product use trajectory group was used to predict substance use and mental health at the fifth assessment. Results Three profiles were identified: (1) tobacco nonusers (N = 2291, 67.5%) with the lowest use prevalence (<3%) of all products across all timepoints; (2) polyproduct users (N = 920, 27.1%) with moderate use prevalence of each product (8–35%) that escalated for combustible cigarettes but decreased for e-cigarettes and hookah across time; and (3) chronic polyproduct users (N = 182, 5.4%) with high prevalence of each product use (38–86%) that escalated for combustible cigarettes and e-cigarettes. Nonusers, polyproduct users, and chronic polyproduct users reported successively higher alcohol, marijuana, and illicit drug use and ADHD at the final follow-up, respectively. Both tobacco using groups (vs. nonusers) reported greater odds of depression and anxiety at the final follow-up but did not differ from each other. Conclusions Adolescent polytobacco use may involve a common moderate risk trajectory and a less common high-risk chronic trajectory. Both trajectories predict substance use and mental health symptomology. Implications Variation in use and co-use of combustible cigarette, e-cigarette, and hookah use in mid-adolescence can be parsimoniously characterized by a small set common trajectory profiles in which polyproduct use are predominant patterns of tobacco product use, which predict adverse behavioral outcomes. Prevention and policy addressing polytobacco use (relative to single product use) may be optimal tobacco control strategies for youth, which may in turn prevent other forms of substance use and mental health problems.
The Effects of Hypericum perforatum L. on the Proliferation, Osteogenic Differentiation, and Inflammatory Response of Mesenchymal Stem Cells from Different Niches

The aim of this study is to demonstrate and compare the differentiation, proliferation, migration and inflammatory behavior of dental pulp- and bone marrow-derived mesenchymal stem cells (DP-MSCs and BM-MSCs) in response to a Hypericum perforatum ethanol extract. Using xCELLigence, a real-time monitoring system, a dose of 10 µg/mL was found to be the most efficient concentration for vitality. The IC50 values and doubling time were calculated. The results showed that H. perforatum L. was able to accelerate osteogenic differentiation in DP-MSCs, but calcium granulation was impaired in BM-MSCs. H. perforatum L. -induced migration increased when compared to the TNF-α-induced migration in a Transwell migration assay, and the IL-6 cytokine levels between cells also differed. It can be suggested that tissue memory is an important factor in MSCs, and that they differ in their response to external factors. In conclusion, H. perforatum L. can be considered an excellent osteoinductive agent for DP-MSCs but should not be used for BM-MSCs. Tissue-specific osteoinductive agents should be discussed in future studies.
Importance mixing: Improving sample reuse in evolutionary policy search methods

Deep neuroevolution, that is evolutionary policy search methods based on deep neural networks, have recently emerged as a competitor to deep reinforcement learning algorithms due to their better parallelization capabilities. However, these methods still suffer from a far worse sample efficiency. In this paper we investigate whether a mechanism known as "importance mixing" can significantly improve their sample efficiency. We provide a didactic presentation of importance mixing and we explain how it can be extended to reuse more samples. Then, from an empirical comparison based on a simple benchmark, we show that, though it actually provides better sample efficiency, it is still far from the sample efficiency of deep reinforcement learning, though it is more stable.
Ensemble-based Adaptive Single-shot Multi-box Detector

We propose two improvements to the SSD—single shot multibox detector. First, we propose an adaptive approach for default box selection in SSD. This uses data to reduce the uncertainty in the selection of best aspect ratios for the default boxes and improves performance of SSD for datasets containing small and complex objects (e.g., equipments at construction sites). We do so by finding the distribution of aspect ratios of the given training dataset, and then choosing representative values. Secondly, we propose an ensemble algorithm, using SSD as components, which improves the performance of SSD, especially for small amount of training datasets. Compared to the conventional SSD algorithm, adaptive box selection improves mean average precision by 3%, while ensemble-based SSD improves it by 8%.
Characterizing the Public Perception of WhatsApp through the Lens of Media

WhatsApp is, as of 2018, a significant component of the global information and communication infrastructure, especially in developing countries. However, probably due to its strong end-to-end encryption, WhatsApp became an attractive place for the dissemination of misinformation, extremism and other forms of undesirable behavior. In this paper, we investigate the public perception of WhatsApp through the lens of media. We analyze two large datasets of news and show the kind of content that is being associated with WhatsApp in different regions of the world and over time. Our analyses include the examination of named entities, general vocabulary, and topics addressed in news articles that mention WhatsApp, as well as the polarity of these texts. Among other results, we demonstrate that the vocabulary and topics around the term "whatsapp" in the media have been changing over the years and in 2018 concentrate on matters related to misinformation, politics and criminal scams. More generally, our findings are useful to understand the impact that tools like WhatsApp play in the contemporary society and how they are seen by the communities themselves.
Thickness-dependent thermoelectric power factor of polymer-functionalized semiconducting carbon nanotube thin films

ABSTRACT The effects of polymer structures on the thermoelectric properties of polymer-wrapped semiconducting carbon nanotubes have yet to be clarified for elucidating intrinsic transport properties. We systematically investigate thickness dependence of thermoelectric transport in thin films containing networks of conjugated polymer-wrapped semiconducting carbon nanotubes. Well-controlled doping experiments suggest that the doping homogeneity and then in-plane electrical conductivity significantly depend on film thickness and polymer species. This understanding leads to achieving thermoelectric power factors as high as 412 μW m−1 K−2 in thin carbon nanotube films. This work presents a standard platform for investigating the thermoelectric properties of nanotubes. GRAPHICAL ABSTRACT
Effect of embryonic thermal manipulation on heat shock protein 70 expression and immune system development in Pekin duck embryos

ABSTRACT Two experiments were conducted to study the effects of thermal manipulation on heat shock protein 70 (HSP70) transcription and immune cell characteristics’ in Pekin duck embryos. In experiments I and II, fertile duck eggs were incubated at either a standard (S; 37°C) or high (H; 38.0°C) temperature from embryonic day (ED) 1 to 10. At ED11, half the eggs incubated at 37.5°C or 38.0°C were either kept at 37.5°C (SS) or 38.0°C (HH) respectively, or moved to the opposite incubator/temperature of either 38.0°C (SH) or 37.5°C (HS). Beginning on ED 21, all eggs (embryos) were incubated at 37.5°C. In experiments I and II, the mean egg shell temperature (EST) of eggs incubated at 38.0°C was higher than that from 37.5°C at ED10 (P < 0.01). In both experiments, the yolk free wet embryo body weight (YFWEBW) of embryos from the HS treatment was increased while that in the HH treatments was decreased compared with the SS treatment at ED25 (P < 0.01). In experiment II, embryos from the HH treatment had increased HSP70 mRNA compared with the SS treatment in the liver, thymus, and bursa (P < 0.05). The thymus and bursa from embryos in the SH treatment had increased MHCI mRNA when compared with the SS treatment (P < 0.05). The thymus from HH and SH treatments had increased MHCII mRNA while the bursa from the HH and SH treatments had decreased MHCII mRNA when compared with the SS treatment (P < 0.05). The spleen and bursa from the HH treatment had increased IL‐6, IFN&ggr;, and IL‐10 mRNA when compared with the SS treatment (P < 0.05). The thymus and spleen from embryos in the HH treatment had increased CD8+/CD4+ ratios and CD4+CD25+ cell percentages compared with the SS treatment (P < 0.05). In conclusion, embryos incubated at 0.5°C higher than the standard incubation temperature from ED1 to 21 had increased HSP70 mRNA, MHCI, and inflammatory cytokines, and the immune response was skewed toward cell‐mediated immunity.
Context-Aware Visual Policy Network for Sequence-Level Image Captioning

Many vision-language tasks can be reduced to the problem of sequence prediction for natural language output. In particular, recent advances in image captioning use deep reinforcement learning (RL) to alleviate the "exposure bias'' during training: ground-truth subsequence is exposed in every step prediction, which introduces bias in test when only predicted subsequence is seen. However, existing RL-based image captioning methods only focus on the language policy while not the visual policy (eg, visual attention), and thus fail to capture the visual context that are crucial for compositional reasoning such as visual relationships (\eg, "man riding horse'') and comparisons (eg. "smaller cat"). To fill the gap, we propose a Context-Aware Visual Policy network (CAVP) for sequence-level image captioning. At every time step, CAVP explicitly accounts for the previous visual attentions as the context, and then decides whether the context is helpful for the current word generation given the current visual attention. Compared against traditional visual attention that only fixes a single image region at every step, CAVP can attend to complex visual compositions over time. The whole image captioning model --- CAVP and its subsequent language policy network --- can be efficiently optimized end-to-end by using an actor-critic policy gradient method with respect to any caption evaluation metric. We demonstrate the effectiveness of CAVP by state-of-the-art performances on MS-COCO offline split and online server, using various metrics and sensible visualizations of qualitative visual context. The code is available at \urlhttps://github.com/daqingliu/CAVP
Predictive value of venous thromboembolism (VTE)‐BLEED to predict major bleeding and other adverse events in a practice‐based cohort of patients with VTE: results of the XALIA study

Venous thromboembolism (VTE)‐BLEED, a decision tool for predicting major bleeding during chronic anticoagulation for VTE has not yet been validated in practice‐based conditions. We calculated the prognostic indices of VTE‐BLEED for major bleeding after day 30 and day 90, as well as for recurrent VTE and all‐cause mortality, in 4457 patients enrolled in the international, prospective XALIA study. The median at‐risk time was 190 days (interquartile range 106–360). The crude hazard ratio (HR) for major bleeding after day 30 was 2·6 [95% confidence interval (CI) 1·3–5·2] and the treatment‐adjusted HR was 2·3 (95% CI 1·1–4·5) for VTE‐BLEED high (versus low) risk patients: the corresponding values for major bleeding after day 90 were 3·8 (95% CI 1·6–9·3) and 3·2 (95% CI 1·3–7·7), respectively. The predictive value of VTE‐BLEED was similar in selected patients with unprovoked VTE or those treated with rivaroxaban. High VTE‐BLEED score was associated with higher incidence of all‐cause mortality (treatment‐adjusted HR 11, 95% CI 4·8–23), but not evidently with recurrent VTE (treatment‐adjusted HR 1·5; 95% CI 0·85–2·7). These results confirm the predictive value of VTE‐BLEED in practice‐based data in patients treated with rivaroxaban or conventional anticoagulation, supporting the hypothesis that VTE‐BLEED may be useful for making management decisions on the duration of anticoagulant therapy.
Effects of prior cold stimulation on inflammatory and immune regulation in ileum of cold‐stressed broilers

ABSTRACT Acclimation can alleviate the negative impacts of adverse environmental factors on an organism. To investigate the effects of prior cold stimulation on inflammatory and immune regulation in ileum of cold‐stressed broilers, 360 1‐d‐old chicks (Arbor Acres) were divided into 3 groups (G1, G2, G3) and raised at normal (thermal comfort) temperatures during 1 to 7 d. From 8 d, G1 (control) continued to be raised at normal temperatures, whereas G2 and G3 (treatments) were cold‐stimulated at 3°C and 12°C, respectively, below the temperature of G1, but not below 17°C (reached at 32 d in G2 and 14 d in G3). At 42 d, all the groups were subjected to a 24‐h acute cold stress of 7°C, designated as S1, S2, and S3. Ileum tissues and serum of the birds were collected at 42 d and 43 d to detect the levels of pro‐inflammatory and immune‐related factors as well as morphology changes. At 42 d, ileum of G1 and G2 had intact morphological structure and clear outline, with no differences in levels of iNOS, NF‐&kgr;B, COX‐2, PTGEs, TNF‐&agr;, IFN‐&ggr;, or IL‐4 (P > 0.05). G3 ileum suffered inflammatory injuries, with levels of iNOS, COX‐2, PTGEs, TNF‐&agr;, and IL‐4 being higher than those of G1 (P < 0.05). At 43 d, compared with G1, S1 had severely damaged ileum, increased levels of iNOS, NF‐&kgr;B, COX‐2, PTGEs, TNF‐&agr;, and IL‐4 (P < 0.05), but decreased level of IFN‐&ggr; (P < 0.05). The morphological structure of S2 was intact, and there were no differences between G2 and S2 in levels of NF‐&kgr;B, PTGEs, TNF‐&agr;, IFN‐&ggr;, or IL‐4 (P > 0.05). Compared with S1, S2 had decreased levels of iNOS, NF‐&kgr;B, COX‐2, PTGEs, TNF‐&agr;, and IL‐4 (P < 0.05), but increased level of IFN‐&ggr; (P < 0.05). There were no differences between G1 and S2 in levels of NF‐&kgr;B, PTGEs, TNF‐&agr;, IFN‐&ggr;, or IL‐4 (P > 0.05). The results demonstrate that a 3°C‐lower‐than‐normal temperature stimulation of the broilers from 8 to 42 d led to cold acclimation. This prior cold acclimation effectively alleviated elevation of pro‐inflammatory cytokines and Th1/Th2 imbalance of the birds induced by subsequent cold stress.
Natural resource wars in the shadow of the future: Explaining spatial dynamics of violence during civil war

Previous studies on natural resources and civil wars find that the presence of natural resources increases both civil conflict risk and duration. At the same time, belligerents often cooperate over resource extraction, suggesting a temporal variation in the contest over this subnational space. This study argues that parties fight over natural resources primarily when they expect that the conflict is about to end, as the importance of controlling them increases in the post-conflict setting. In contrast, belligerents that anticipate a long war have incentives to avoid fighting near natural resources since excessive violence will hurt the extraction, trade, and subsequent taxation that provide conflict actors with income from the resource. We test our argument using yearly and monthly grid-cell-level data on African civil conflicts for the period 1989–2008 and find support for our expected spatial variation. Using whether negotiations are underway as an indicator about warring parties’ expectations on conflict duration, we find that areas with natural resources in general experience less intense fighting than other areas, but during negotiations these very areas witness most of the violence. We further find that the spatial shift in violence occurs immediately when negotiations are opened. A series of difference-in-difference estimations show a visible shift of violence towards areas rich in natural resources in the first three months after parties have initiated talks. Our findings are relevant for scholarship on understanding and predicting the trajectories of micro-level civil conflict violence, and for policymakers seeking to prevent peace processes being derailed.
The Role of Product Design in Creating Circular Business Models: A Case Study on the Lease and Refurbishment of Baby Strollers

In the transition to a circular economy companies are exploring new business models, implying a shift from selling products to offering products in circular business models, such as leasing. Product design is thought to play a crucial role in enabling this. Having a robust overview of relevant design roles and competencies is of foundational importance for the development of circular design tools and methods, and for the development of circular economy-based design curricula in higher education. However, how the role of design and the competencies required by designers need to change has hardly been investigated. Building on insights from literature regarding competencies of designers required to consider sustainability, sustainable design, and circular design, we developed a framework in which these competencies are related to the functional, coordinating, and strategic roles that have been recognized within the literature for designers. To complement the results from the literature with insights from practice, a single longitudinal in-depth case study was carried out describing a lease and refurbishment pilot conducted by a Dutch design-driven manufacturer of baby strollers. This case study allowed verification of the literature regarding the functional and coordinating roles of the designer. In addition, we were able to fill the gap observed in the literature regarding the strategic role product designers can assume when designing offers for circular business models. The competencies that we found are (1) the ability to concurrently develop the circular business model and the product’s design and (2) the ability to anticipate how the circular offering will evolve over multiple lifecycles. These findings have been used to expand the framework.
Religiosity and the Impact on Relationship Quality

Religiosity is important for relationship maintenance. However, past studies are inconsistent regarding the impact of individual and partner religiosity for relationship quality. In addition, many studies focus on married couples and use single-item measures of religiosity. The goal of this study is to test the religiosity of relationships as a mediator between individual and partner religiosity for relationship quality of dating couples, using stringent measures of centrality of religiosity. Participants completed a survey regarding their religiosity, their partners’ religiosity, and the religiosity of their relationships (N=119). Mediation analyses showed that relationship religiosity fully mediated the relationship between individual religiosity and relationship satisfaction and fully mediated the relationship between partner religiosity and relationship satisfaction. Results from the study emphasize the importance of religious activities for dating couples. Further implications will be discussed.
L-Dopa and Fluoxetine Upregulate Astroglial 5-HT 2 B Receptors and Ameliorate Depression in Parkinson ’ s Disease Mice

Here, we report the association between depressive behavior (anhedonia) and astroglial expression of 5-hydroxytryptamine receptor 2B (5-HT2B) in an animal model of Parkinson’s disease, induced by bilateral injection of 6-hydroxydopamine (6-OHDA) into the striatum. Expression of the 5-HT2B receptor at the mRNA and protein level was decreased in the brain tissue of 6-OHDA-treated animals with anhedonia. Expression of the 5-HT2B receptor was corrected by four weeks treatment with either L-3,4-dihydroxyphenylalanine (L-dopa) or fluoxetine. Simultaneously, treatment with L-dopa abolished 6-OHDA effects on both depressive behavior and motor activity. In contrast, fluoxetine corrected 6-OHDA-induced depression but did not affect 6-OHDA-induced motor deficiency. In addition, 6-OHDA downregulated gene expression of the 5-HT2B receptor in astrocytes in purified cell culture and this downregulation was corrected by both L-dopa and fluoxetine. Our findings suggest that 6-OHDA-induced depressive behavior may be related to the downregulation of gene expression of the 5-HT2B receptor but 6-OHDA-induced motor deficiency reflects, arguably, dopamine depletion. Previously, we demonstrated that fluoxetine regulates gene expression in astrocytes by 5-HT2B receptor-mediated transactivation of epidermal growth factor receptor (EGFR). However, the underlying mechanism of L-dopa action remains unclear. The present work indicates that the decrease of gene expression of the astroglial 5-HT2B receptor may contribute to development of depressive behavior in Parkinson’s disease.
Food practices of environmentally conscientious New Zealanders

ABSTRACT Practice theory as applied to consumer behaviours is an area of enquiry presently gaining momentum. In this article, I draw on practice theory as a way to understand change as it relates to environmentally conscientious (EC) food consumption. The main question asked here is: how does concern about food consumption develop and translate into practice, and what forms does this take? Also, the relationship of these practices to wider social structures is explored as a means to theorise in what ways more environmentally sustainably food practices might be more readily enabled. I turn to the experiences and practices of 51 self-identified EC individuals, as relayed across a series of ‘go-along’ interviews. This research shows that early socialisation that incorporates a frugality ethic and food self-provisioning is most likely to habitualise EC food practice later in life, where food self-provisioning is key. It is the material infrastructural challenges that mostly thwart efforts at EC food practice: the Western global food regime is not pro-environmental, and resource limitations on a microlevel, for example with access to land for self-provisioning.