Miracle-dz/UniFAR-FTUs huggingface dataset:
Underutilization of transbronchial needle aspiration: experiences of current pulmonary fellows.

Transbronchial needle aspiration (TBNA) is a valuable, minimally invasive procedure for diagnosing and staging lung cancer in patients, but it is underutilized by practicing pulmonologists. To assess the approach to TBNA of current pulmonary Fellows, we recorded their computerized interactive responses during the 1995 American College of Chest Physicians Fellows' Conference. Among 109 Fellows attending, only 10% reported that they routinely (> or = 85% of cases) performed TBNA to diagnose or stage malignant disease, and 40% noted that they rarely (< or = 5% of cases) performed it. They estimated their diagnostic TBNA yields in patients with mediastinal cancer as follows: > or = 80% by 2% of Fellows; between 25% and 80% by 54% of Fellows; and < 25% by 45% of Fellows. They noted that the main limitations of TBNA at their institutions were suboptimal bronchoscopy technique (30%), technician support (1%), cytopathology support (14%), all of these factors (25%), or the belief that TBNA is not useful (30%). TBNA is currently underutilized and/or underemphasized at bronchoscopy training programs. Major modifications of Fellow experiences are necessary if TBNA is to impact optimally on patient management.
Microwork platforms as enablers to new ecosystems and business models: the challenge of managing difficult tasks

We explore how microwork platforms manage difficult tasks in paid crowdsourcing environments. We argue that as human computation becomes more prevalent, notably in the context of big data ecosystems, microwork platforms might have to evolve and to take a more managerial stance in order to provide the right incentives to online workers to handle difficult tasks. We illustrate this first through a name disambiguation experiment on Amazon Mechanical Turk (AMT), a well-known microwork platform, and second through direct analysis of the dynamics of task execution in a dataset of real microwork projects on AMT. We discuss the emergence of more specialised microwork platforms as an attempt to facilitate a better management of difficult tasks in the context of paid crowdsourcing.
A PCR-Based RFLP Analysis of Sarcocystis cruzi (Protozoa: Sarcocystidae) in Yunnan Province, PR China, Reveals the Water Buffalo (Bubalus bubalis) as a Natural Intermediate Host

A polymerase chain reaction–based restriction fragment length polymorphism (RFLP) approach is used to examine Sarcocystis cruzi–like taxa from the atypical intermediate host, water buffalo, in Yunnan, People's Republic of China. The loci examined lie within the 18S rRNA gene. A total of 15 water buffalo isolates are compared with those of 10 S. cruzi from cattle. RFLP patterns for the S. cruzi isolates from cattle and the S. cruzi–like taxon from water buffalo are found to be identical with all the 12 restriction enzymes used. Interpopulation variation between samples from Kunming and Gengma (Yunnan) is found to be undetectable at these loci for both S. cruzi and the S. cruzi–like taxon. But RFLPs are found between the S. cruzi taxa and S. suihominis from pigs at the same study sites. These findings support the hypothesis that S. cruzi is able to use the water buffalo as an intermediate host and is not restricted to cattle as was previously supposed.
Prevalence of Anti-Cardiolipin and Anti-β2 Glycoprotein Antibodies in Indian Systemic Lupus Erythematosus Patients

Anti-phospholipid antibodies (APA) like anti-cardiolipin antibodies (ACA) and anti-β2glycoprotien (anti-β2GP) are important cause of venous and arterial thrombosis and other occlusive vascular diseases. The prevalence of these antibodies in SLE patients at the time of diagnosis is not known in Indian SLE patients. This study was conducted to evaluate the prevalence of ACA and anti-β2GP autoantibodies in SLE patients and to correlate them with disease activity and immune parameters such as C3, C4 and CRP levels. where 85 SLE patients referred from Rheumatology Department, KEM hospital, Mumbai were studied. SLE disease activity was evaluated by SLE Disease Activity Index (SLEDAI) score at the time of evaluation. All patients studied were in an active stage of disease of which 37.6% patients had renal disorders, which were categorized as Lupus Nephritis (LN) and 62.3% patients did not show any renal manifestations (non-LN). ACA and anti-β2GP autoantibodies, to IgG and IgM subclasses were tested by ELISA. C3, C4 and CRP levels were detected by nephelometer. It was observed that 12.9% patients were IgG-ACA and IgM-ACA positive and ACA positivity was noted more among LN group Anti-β2GP autoantibody positivity was 27.1% for IgG and 31.8% for IgM. , IgG-anti-β2GP antibodies were slightly higher in non-LN patients, whereas a higher incidence of IgM-anti-β2GP antibodies were detected in LN patients. Hence detection both ACA and anti-β2GP antibodies along with associated immune parameters were helpful to evaluate their possible association with disease severity in SLE patients. A long term follow up of patients having ACA and anti-β2GP antibodies without thrombotic event is also needed to detect their possible thrombotic event in future along with their clinical presentation.
Combined infection by Moloney murine leukemia virus and a mink cell focus-forming virus recombinant induces cytopathic effects in fibroblasts or in long-term bone marrow cultures from preleukemic mice

We described previously a preleukemic state in mice inoculated with Moloney murine leukemia virus (M-MuLV) characterized by generalized hematopoietic hyperplasia in the spleen. To investigate this further, long-term bone marrow cultures (LTBMC) from preleukemic mice were established. Surprisingly, LTBMC from M-MuLV-inoculated preleukemic mice showed less hematopoiesis than LTBMC from control mice. This resulted from a quantitative defect in establishment of bone marrow stromal cells in the LTBMC. This phenomenon could also be observed in LTBMC from normal mice infected in vitro with a stock of M-MuLV containing a mink cell focus-forming virus (MCF) derivative (M-MCF), but not in LTBMC infected with M-MuLV alone. This implicated MCF derivatives in the reduction in bone marrow stromal cells. The phenomenon could also be detected in infected NIH 3T3 cells. Combined infection of M-MuLV plus M-MCF resulted in fewer cells, in comparison to uninfected cells or cells infected with either virus alone. Further studies indicated that this was predominantly due to an inhibition in cell growth rather than to cell lysis. The cytopathic effect did not appear to result from overreplication of viral DNA, as measured by Southern blots. Thus, combined infection with M-MuLV and an MCF derivative had cytostatic effects on cell growth. This phenomenon might also contribute to the leukemogenic process in vivo.
Identification of Athletes at Future Risk of Anterior Cruciate Ligament Ruptures by Neuromuscular Screening

Background A high percentage of female athletes who sustain an anterior cruciate ligament (ACL) rupture suffer serious long-term consequences such as osteoarthritis and disability. Thus, identification of risk factors has high clinical relevance in the prevention of ACL rupture. Hypothesis Noninjured athletes with low knee flexor electromyography (EMG) preactivity and high knee extensor EMG preactivity during sidecutting are at increased risk of future ACL rupture. Study Design Cohort study (prognosis); Level of evidence, 2. Methods Fifty-five elite female athletes (team handball and soccer) aged 24 ± 5 years with no history of ACL injury were tested for EMG preactivity of vastus lateralis and medialis, rectus femoris, semitendinosus, and biceps femoris during a standardized side-cutting maneuver. The incidence of ACL ruptures was registered in the following 2 match seasons. Results During the subsequent 2 match seasons, 5 athletes sustained a confirmed noncontact ACL rupture. Before injury, all 5 players displayed a neuromuscular pattern that differed from the noninjured players, characterized by reduced EMG preactivity for the semitendinosus (ST) and elevated EMG preactivity for the vastus lateralis (VL) (P < .01). On the basis of these findings, a high-risk zone was defined as one standard deviation above the mean VL-ST difference. In our population, 5 of 10 subjects with a VL-ST difference in this zone sustained an ACL injury during the study period. Conclusion In the present study, currently noninjured female athletes with reduced EMG preactivity of the ST and increased EMG preactivity of the VL during side cutting were at increased risk of future noncontact ACL rupture. Our data indicate that a high-risk zone can be used to identify noninjured players at high risk of future ACL rupture. Consequently, individual preventive efforts can be introduced in time. However, large prospective studies are needed to confirm this finding before definitive clinical recommendations can be made.
Application of support vector machines to sensor fault diagnosis in ESP system

Sensor prediction models in ESP system are constructed with support vector machines (SVMs) regression algorithm. Thus SVMs are used as residual generator via analytical redundancy of the sensors. DAGSVM classification algorithm fulfills sensor fault isolation. The research's result shows the application of SVMs to sensor fault diagnosis in ESP system is effective and feasible.
Antecedents of IS Backsourcing

This research examines the change in the sourcing of corporate IS function and grounds for the decision to return IS back in-house. A model of factors affecting IS backsourcing that integrates transaction cost theory and agency theory is presented. In this model costs, goal conflict, and opportunism all influence the decision to backsource. Identifying the underlying causes for undertaking backsourcing can provide managers with more effective decision tools when reviewing outsourcing contracts or responding to changes in the company as well as in the environment.
Laboratory-scale production of (S)-reticuline, an important intermediate of benzylisoquinoline alkaloids, using a bacterial-based method

Benzylisoquinoline alkaloids (BIAs) are a group of plant secondary metabolites that have been identified as targets for drug discovery because of their diverse pharmaceutical activities. Well-known BIAs are relatively abundant in plants and have therefore been extensively studied. However, although unknown BIAs are also thought to have valuable activities, they are difficult to obtain because the raw materials are present at low abundance in nature. We have previously reported the fermentative production of an important intermediate (S)-reticuline from dopamine using Escherichia coli. However, the yield is typically limited. Here, we improved production efficiency by combining in vivo tetrahydropapaveroline production in E. coli with in vitro enzymatic synthesis of (S)-reticuline. Finally, 593 mg of pure (S)-reticuline was obtained from 1 L of the reaction mixture. Because this bacterial-based method is simple, it could be widely used for production of (S)-reticuline and related BIAs, thereby facilitating studies of BIAs for drug discovery. Graphical abstract High amount of pure (S)-reticuline.
Norms for the Eating Disorder Examination Questionnaire (EDE-Q) Among High School and University Men

This study aimed to establish normative and reliability data for the Eating Disorder Examination-Questionnaire (EDE-Q) in a sample of high school and university men. A total of 250 men aged 15 to 30 years (mean = 19.7; SD = 2.3) with an average BMI of 23.1 (SD = 3.1) were administered the EDE-Q. Mean global EDE-Q was 0.44 (SD = 0.52), with subscale means ranging from 0.15 (SD = 0.38) for eating concern to 0.70 (SD = 0.81) for shape concern. EDE-Q scores among this non-clinical sample of normal-weight young men were significantly, and almost invariably, lower than similarly aged young women. The EDE-Q performed less reliably among men than women, and this is an important caveat. Owing to the overall pattern of low item endorsement, reliance upon this single instrument is unlikely to provide a comprehensive assessment of shape, weight, and eating concerns among normal-weight young men in the community.
Carrier frequency acquisition and tracking for OFDM systems

We present and analyze a technique for fast acquisition and accurate tracking of the carrier frequency in orthogonal frequency division multiplexing (OFDM) receivers. The scheme is based on a data-aided frequency estimation algorithm. The presence of known symbol sequences periodically inserted in the OFDM frame allows the data demodulator to rapidly lock onto the carrier frequency during the acquisition phase, even in the presence of frequency offsets up to a few tenths of the overall signaling rate. Once acquisition is over, the circuit switches to a decision-directed mode to perform fine frequency tracking for reliable data demodulation. The algorithm performance is analyzed in terms of width of the lock-in frequency range and of lock-in probability in the acquisition mode, and of mean-square frequency estimation error in the tracking mode. Since OFDM is known to be extremely sensitive to carrier frequency errors, the impact of the carrier frequency synchronizer on the receiver error rate is also investigated.
Changes of marketing culture expression: comparison analysis in times of economic recession and recovery

Abstract In the contemporary competitive environment, companies strive to gain competitive advantage in their business. Strengthening a company’s position in the market is closely related to marketing culture. The article aims at revealing which marketing culture dimensions come into the force in hard times and how these change as hard times inch away and the economy recovers. Seeking to reveal the change tendencies of marketing culture expression in Lithuania, firstly the conception of marketing culture is presented and its elements and peculiarities examined; then the research methodology is presented together with the comparative analysis and interpretation of the findings of questionnaire surveys.
Bacteriophage T4 RNA ligase 2 (gp24.1) exemplifies a family of RNA ligases found in all phylogenetic domains

RNA ligases participate in repair, splicing, and editing pathways that either reseal broken RNAs or alter their primary structure. Bacteriophage T4 RNA ligase (gp63) is the best-studied member of this class of enzymes, which includes yeast tRNA ligase and trypanosome RNA-editing ligases. Here, we identified another RNA ligase from the bacterial domain—a second RNA ligase (Rnl2) encoded by phage T4. Purified Rnl2 (gp24.1) catalyzes intramolecular and intermolecular RNA strand joining through ligase-adenylate and RNA-adenylate intermediates. Mutational analysis identifies amino acids required for the ligase-adenylation or phosphodiester synthesis steps of the ligation reaction. The catalytic residues of Rnl2 are located within nucleotidyl transferase motifs I, IV, and V that are conserved in DNA ligases and RNA capping enzymes. Rnl2 has scant amino acid similarity to T4 gp63. Rather, Rnl2 exemplifies a distinct ligase family, defined by variant motifs, that includes the trypanosome-editing ligases and a group of putative RNA ligases encoded by eukaryotic viruses (baculoviruses and an entomopoxvirus) and many species of archaea. These findings have implications for the evolution of covalent nucleotidyl transferases and virus-host dynamics based on RNA restriction and repair.
Functional imaging with FENSI: Flow‐enhanced signal intensity

Flow measurement methods for functional MRI (fMRI) are desirable as they are more closely tied to neuronal activity than the commonly used blood oxygenation techniques. In this work we introduce a flow‐based functional imaging method. The method, called flow enhancement of signal intensity (FENSI), is an extension of the diffusion enhancement of signal and resolution (DESIRE) method from MR microscopy. The FENSI method offers a localized flow‐weighted signal across a very thin slice (0.4 mm in this study) that provides a signal enhancement that is dependent on the velocity and direction of the flow. The FENSI method was implemented on a human 3 T system and applied to a blocked visual cognitive task. Activation maps showed good localization and the measured signal changes of around 10% were in good agreement with the predicted enhancements. Magn Reson Med 58:396–401, 2007. © 2007 Wiley‐Liss, Inc.
Frequencies of the common promoter polymorphisms in cytokine genes in a Polish population

Common polymorphisms in cytokine genes, widely distributed in many populations, may affect gene transcription, leading to individual variations in cytokine levels. Some of those polymorphisms were associated with the risk of graft rejection or autoimmune and parasitic diseases development as well as treatment outcome. In the current study the frequencies of promoter polymorphisms in genes encoding interleukin‐2 (−330 G/C), interleukin‐4 (−590 C/T), interleukin‐6 (−174 G/C), interleukin‐10 (−1082 G/A, −592 C/A) and TNFα (−307 G/A) have been studied in a sample of 205 unrelated healthy Polish subjects of Caucasian origin. The frequencies of the determined cytokine alleles were as follows: interleukin‐2 (−330 G/C): T −64.9%, G −35.1%; interleukin‐4 (−590 C/T): C −79.8%, T −20.2%; interleukin‐6 (−174 G/C): G −53.4%, C −46.6%; interleukin‐10 (−1082 G/A, −819 G/T, −592 C/A): GCC −44.1%, ACC −32.0, ATA −23.9%; TNFα (−307 G/A): G −85.1%, A −14.9%. We also compared our results with other populations studied to date, describing some significant differences.
Perfluorocarbon-based Oxygen Delivery

The basic properties of perfluorocarbons (PFCs) and PFC emulsions relevant to their use as oxygen delivery systems are briefly reviewed. The key issues related to the selection of an appropriate, readily excretable PFC and the engineering of a stable injectable PFC emulsion are discussed. OxygentTM, a terminally heat-sterilized, injectable 60% w/v PFC emulsion made primarily of F-octyl bromide and a few percent of F-decyl bromide, with egg phospholipids as an emulsifier, has been developed. Its efficacy in avoiding and reducing red cell transfusion during surgery has been established during a Phase III clinical evaluation. Another Phase III clinical trial in cardiopulmonary bypass surgery, with a protocol that included both augmented-acute normovolemic hemodilution and intraoperative autologous donation, has, however, been interrupted following the observation of adverse events. Data analysis assigned these events to an inappropriate study protocol. A search for possible interactions between Oxygent and fluids present during cardiopulmonary bypass surgery detected no effect of the emulsion on hemostasis, hemolysis and blood rheology.
Difference in the Relative Distribution of CD4+ T-cell Subsets in B-CLL With Mutated and Unmutated Immunoglobulin (Ig) VH Genes: Implication for the Course of Disease

B-cell chronic lymphocytic leukemia (B-CLL) is a clinically heterogeneous disease in which the clinical course is influenced by the presence or absence of immunoglobulin (Ig) variable heavy chain (VH) gene mutations. The poor clinical outcome of the subgroup with unmutated Ig VH genes has been linked to the persistent ability of the B-cell receptor in tumor cells from these cases to respond to antigen. As B-cell receptor signaling generally relies on T-cell help, we hypothesized that the course of B-CLL might not only be influenced by the Ig VH mutational status but also by the activation/differentiation status of T cells. We assessed the relative distribution of naive and memory T-cell subsets in peripheral blood from patients with mutated (M-CLL, n=71) and unmutated Ig VH genes (UM-CLL, n=42) and correlated it with the course of disease. We also compared the prosurvival potential of naive and memory T cells cocultured with B-CLL cells in vitro. A significant increase in relative numbers of central and effector memory T cells was observed in the CD4+ T-cell pool from UM-CLL as compared with M-CLL cases and was associated with high Rai stage, progressive disease and shorter treatment-free survival (TFS). In a multivariate analysis, the relative number of CD4+ central and effector memory T cells remained a significant prognostic parameter for TFS after correction for CD38 expression, Ig VH status, genomic aberrations, and Rai stage. The inverse correlation of memory CD4+ T cells with TFS might be explained by their potential to support survival of B-CLL cells.
Parental Support and Objectively Measured Physical Activity in Children: A Yearlong Cluster-Randomized Controlled Efficacy Trial

ABSTRACT Purpose: We studied whether physical activity (PA) counseling for parents influenced the level of parental support of children’s PA and leisure-time PA in children of different levels of initial parental support. We hypothesized that the initial level of parental support would moderate the intervention efficacy. Method: Children (n = 44, Mage = 6.09 ± 1.17 years) and their parents (n = 61) randomly assigned to an intervention group received counseling for 6 months. Children in the control group (n = 47, Mage = 6.12 ± 1.11 years) and their parents (n = 63) did not receive any counseling. Parental support was assessed using the Family Physical Activity Environment Questionnaire, and children’s leisure-time PA was recorded using triaxial accelerometers at baseline, at 6 months, and at 12 months. The efficacy of the intervention was tested by linear mixed-effects modeling adjusted for confounding variables (Model 1) and additionally for children’s participation in organized PA or sports (Model 2). Results: Parents within the lowest initial parental support intervention tertile significantly increased their support, and their children’s mean level of leisure-time PA significantly improved compared with the corresponding controls during the counseling period. On the other hand, intervention was found to have an unfavorable influence especially in the PA of children of initially highly supportive parents. Conclusion: Targeting PA counseling for parents with low support of their children’s PA could contribute to better family-based PA counseling efficacy.
EPCglobal Class 1 Gen 2标准的RFID高效双向认证协议

通过对EPCglobal Class 1 Gen 2标准下典型RFID双向认证协议进行分析和比较,针对大规模标签环境下协议效率低下的问题,提出一种改进方案,能够有效抵御消息泄漏、重放、伪装、定位跟踪、DoS等常见攻击,并提高了协议执行效率。