Miracle-dz/UniFAR-FTUs huggingface dataset:
A Gene Expression–based Model to Predict Metabolic Response After Two Courses of ABVD in Hodgkin Lymphoma Patients

Purpose: Early response to ABVD, assessed with interim FDG-PET (iPET), is prognostic for classical Hodgkin lymphoma (cHL) and supports the use of response adapted therapy. The aim of this study was to identify a gene-expression profile on diagnostic biopsy to predict iPET positivity (iPET+). Experimental Design: Consecutive untreated patients with stage I–IV cHL who underwent iPET after two cycles of ABVD were identified. Expression of 770 immune-related genes was analyzed by digital expression profiling (NanoString Technology). iPET was centrally reviewed according to the five-point Deauville scale (DS 1-5). An iPET+ predictive model was derived by multivariate regression analysis and assessed in a validation set identified using the same inclusion criteria. Results: A training set of 121 and a validation set of 117 patients were identified, with 23 iPET+ cases in each group. Sixty-three (52.1%), 19 (15.7%), and 39 (32.2%) patients had stage I–II, III, and IV, respectively. Diagnostic biopsy of iPET+ cHLs showed transcriptional profile distinct from iPET−. Thirteen genes were stringently associated with iPET+. This signature comprises two functionally stromal-related nodes. Lymphocytes/monocytes ratio (LMR) was also associated to iPET+. In the training cohort a 5-gene/LMR integrated score predicted iPET+ [AUC, 0.88; 95% confidence interval (CI), 0.80–0.96]. The score achieved a 100% sensitivity to identify DS5 cases. Model performance was confirmed in the validation set (AUC, 0.68; 95% CI, 0.52–0.84). Finally, iPET score was higher in patients with event versus those without. Conclusions: In cHL, iPET is associated with a genetic signature and can be predicted by applying an integrated gene-based model on the diagnostic biopsy.
Quality-of-life Evaluation of Healthy Siblings of Children with Chronic Illness

Background: Chronic disease of children can cause changes in the health-related quality of life (HrQoL) of the family members. Aims: To evaluate the HrQoL of healthy siblings of children with chronic disease. Study Design: Cross-sectional study. Methods: The study included healthy sibling of children with chronic disease (cerebral palsy, epilepsy, diabetes, celiac disease, hematologic/oncologic disease, or asthma) and healthy sibling of healthy children to evaluate the quality of life. We used the Pediatric Quality of Life Inventory questionnaire; the physical health and psychosocial health scores were calculated using the responses of the sibling and parent. The primary endpoint was the comparison of HrQoL scores of healthy siblings of children with chronic disease and that of healthy siblings of healthy children. Results: This study included a respective healthy sibling of 191 children with chronic disease and healthy sibling of 100 healthy children. The physical health, psychosocial health, and total health scores of healthy siblings of children with chronic disease were significantly lower than that of healthy siblings of healthy children (p<0.001). Among the healthy siblings of children with chronic disease, the lowest psychosocial health score was found in the siblings of children with cerebral palsy, hematologic/oncologic disease, and asthma (p<0.001). The global impact on the quality of life for healthy siblings of children with chronic disease was significantly higher in the self-report of the children than that of the parents (30.4% versus 15.1%, p<0.05). Conclusion: Most healthy siblings of children with chronic disease are physically and psychosocially affected and there is low parental awareness of this condition. This can increase the risk of emotional neglect and abuse of these children. Therefore, special support programs are needed for the families of children with chronic diseases.
Summary and Conclusions From the Academy's Sixth State-of-the-Science Conference on Lower Limb Prosthetic Outcome Measures

GOALS OF THE STATE-OF-THE-SCIENCE CONFERENCE NO. 6 (SSC6) This State-of-the-Science Conference was convened to examine the body of scientific knowledge related to lower limb prosthetic (LLP) outcome measures. The meeting was held September 7 through 9, 2005, in Chicago, Illinois, and funding for this conference was provided by the American Academy of Orthotists and Prosthetists through a grant from the US Department of Education. Experts in the field were invited to offer their insight and expertise in summarizing the evidence and identifying key areas for future research. It was the goal of the conference to examine, debate, and answer these questions: 1) What validated instruments are available in English to measure global lower limb prosthetic outcomes? 2) What do these instruments attempt to measure? 3) What are the relative strengths and weaknesses of current instruments? 4) What are the barriers to clinical application of these tools? 5) In light of the literature review and the panel’s discussion, what are the primary future research priorities? To address questions 1 and 2, a comprehensive written review of the literature was completed by Elizabeth Condie, PT, FCSP, and colleagues. Copies of the relevant articles selected for review were made available to the participants before the meeting. In preparation for the conference, participants were asked to review the literature applicable to questions 3 and 4. Selected participants were asked to present their experience with specific tools (question three), whereas other participants were asked to provide certain perspectives on the clinical application of outcome measurement tools (question 4).
The Effect of Emotional Exhaustion on Workplace Ostracism and Job Insecurity in North Cyprus Hotel Industry

The aim of this study is to investigate the mediating effects of employee emotional exhaustion (EE) on workplace ostracism (WO) and job insecurity (JI) using the theory of resource conservation. In this research, structural equality modeling was conducted through 211 questionnaires, working in Hotels in Northern Cyprus. For data analysis used Microsoft Excel and Statistical Software Programs including SPSS and AMOS. The study results show that the gradual convergence of emotional exhaustion due to incapacity can lead to an increase in negative effects on job insecurity or ostracism in the workplace which gradually increases over time, impacting negatively on and ultimately increasing workplace ostracism. Although, the studies on exhaustion and insecurity in the workplace increase, “the individual perceives that they are ignored or excluded by others”, furthermore, there has not been sufficient attention on the effects of emotional exhaustion workplace ostracism and group unemployment. Therefore, this study will lead to future studies.
Trust and Technology Repair Infrastructures in the Remote Rural Philippines

This paper analyzes the processes and challenges of technology repair in remote, low-income areas far from standard ICT repair infrastructure. Our sites of study are the fishing and farming villages of Dibut, Diotorin, and Dikapinisan in Aurora Province, Philippines, located in coastal coves against a mountain range. Residents are geographically isolated from urban areas, with the nearest peri-urban center of Baler a boat trip of several hours away, infeasible in some sea conditions. Unlike prior work in more connected rural areas, there are no local repair shops and device repair is uncommon, despite frequent breakage due to harsh conditions for electronics. The scarcity of local electronics repair limits technology access and leads to accumulation of e-waste. While prior work demonstrates that local electronics repair capability does arise in many rural areas around the world, we must also acknowledge that the successful emergence of this infrastructure depends on the intersection of many structural conditions and cannot be taken for granted. We present the material hardships of achieving local repair in terms of seams between heterogeneous urban and rural infrastructures, which illustrate the cove communities' marginality with respect to many forms of public infrastructure. However, intermittent and informal repair infrastructures based on trust relationships emerge to patch these seams in remote settings. We show how trust affects the way people dynamically construct repair infrastructure and why, based on their remoteness and the resulting value propositions of repair. Networks of trust between repairers, their clients, suppliers, fellow repairers, and certifying or training institutions crucially facilitate the movement of resources and expertise across the Philippines, but also reinforce the marginality of residents and repairers in the coves. Despite these structural challenges, local people are able to maintain a robust ecosystem for rural electrical line repair, from which we generalize the model of training grounds as a strategy for sustaining local communities of repair experts.
Equational-intensional relative clauses with syntactic reconstruction1

Analyses of scope reconstruction typically fall into two competing approaches: ‘semantic reconstruction’, which derives non-surface scope using semantic mechanisms, and ‘syntactic reconstruction’, which derives it by positing additional syntactic representations at the level of Logical Form. Grosu and Krifka (2007) proposed a semantic-reconstruction analysis for relative clauses like the gifted mathematician that Dan claims he is, in which the relative head NP can be interpreted in the scope of a lower intensional quantifier. Their analysis relies on type-shifting the relative head into a predicate of functions. We develop an alternative analysis for such relative clauses that replaces type-shifting with syntactic reconstruction. The competing analyses diverge in their predictions regarding scope possibilities in head-external relative clauses. We use Hebrew resumptive pronouns, which disambiguate a relative clause in favor of the head-external structure, to show that the prediction of syntactic reconstruction is correct. This result suggests that certain type-shifting operations are not made available by Universal Grammar.
Understanding the Social Network in Cooperative Games

Nowadays, Online Social Network (OSN) such as Facebook has become a prominent communication tool which serves hundreds of millions of users. However, the OSN is not the only method that people can communicate with each other on the Internet. In this paper, we adopt the social network analysis approach partially and apply it to online cooperative games studies with some mapping strategy. To achieve that, we present a previous case study which investigated social network existed in Defense of the Ancients (DotA) to show how social network works in computer games. Afterwards we discuss the implication and limitation of the study. Keywords— Online Social Network, Social Network Analysis, online cooperative games.
1626 CJHS 24.1_01_Bauer .Comm. 1..11

Research on the sexual health of trans women (male-to-female spectrum transgender people), has focused primarily on sexual response and satisfaction after initiating hormone treatment or undergoing genital surgery, or on HIV-related sexual risk among trans women sexually active with cisgender (cis, i.e., non-trans) men. Given that these situations are not representative of the majority of trans women at most points in the lifecourse, a broader discussion is needed to provide sex educators, therapists, clinicians, and researchers, as well as trans women and their partners, with information needed to promote sexual health. Drawing on the theoretical constructs of cisnormativity and cissexism, as well as previously published and new data from Trans PULSE, a community-based study of trans health in Ontario, we discuss the social context and sexual realities of trans women’s lives.
Adsorption of DNA on Coated Magnetic Beads: Comparison of Physical and Chemical Adsorption

Kendilerine has ozellikleri nedeniyle cesitli demir manyetik nanopartikullerin ayirma ve yogunlastirma uygulamalarinda mukemmel nanomateryal olduklari kanitlanmistir. Deoksiribonukleik asit (DNA) molekullerinin manyetik kurelere immobilizasyonu son derece onemli olmakla birlikte DNA ekstraksiyonu, yogunlastirilmasi, biyosensorler, mikrodiziler ve yeni nesil dizileme gibi bircok teknikte potansiyel kullanim alanina sahiptir. Bu calismada, poli-l-lizin miktari, baslangic ​​DNA konsantrasyonu, iyonik kuvveti, baglanma tipi ve DNA uzunlugunun degisen kosullari altinda poli-l-lizin kapli demir oksit manyetik kureler araciligiyla tek iplik DNA'nin (ssDNA) adsorpsiyonu, gerceklestirilmistir. Adsorpsiyon islemi Langmuir ve Freundlich izoterm modelleri ile incelenmistir. Negatif yuklu DNA ile pozitif yuklu manyetik kureler arasindaki iyonik etkilesimi Freundlich adsorpsiyon izotermiyle cok katmanli adsorpsiyon, modeli gosterirken, DNA ve yuzey arasindaki kovalent baglanma Langmuir adsorpsiyon izoterminde daha yuksek adsorpsiyon verimi gostermistir. Her iki adsorpsiyon yontemi, manyetik kurelere uygun ssDNA adsorpsiyonu saglamistir.
Automatic Retinal Disease Classification Using Machine Learning and AI

patients get preventive care. Yet, due to lack of infrastructure and resources millions of patients do not avail such diagnosis. In this paper, I explore the possibility of developing an automatic retinal disease classifier using computer vision algorithms. Two different classes of algorithms are tested; (a) traditional computer vision approach of hand crafting features followed by developing machine learning (ML) models (b) automatic feature engineering and classification using more modern convolutional neural networks (CNN). The above algorithms were used to build both multi-class classifiers, i.e. the models which are trained to identify the correct disease, and binary classifiers, i.e. models that are trained to determine if a patient has a specific disease or not. A set of 600 pre-labelled retinal scan images were used to train the models. Both the ML and CNN models had relatively modest success in the multiclass scenario. However, the ML models were found to be reliably accurate in binary classification scenario, achieving >90% accuracy in identifying cataract.
Application of Fuzzy Decision Trees for Rubricating Unstructured Electronic Text Documents

Every day, a large number of electronic text messages (complaints, appeals, suggestions, etc.) presented in unstructured form arrives on the Internet portals of public authorities. The quality and speed of automated processing of such requests directly depend on the correctness of their rubrication (assignment to a specific subject area). The distinctive features of these messages (small size, presence of errors, lack of a certain structure, etc.) do not allow using the wellknown methods of categorizing text documents. The authors have developed a model for rubricating electronic unstructured text documents taking into account syntactic links and word roles in the sentences on basis of fuzzy decision trees. The construction of a decision tree is based on analyzing the degree of rubric dictionary intersection and the distances between rubrics in the n-dimensional feature space. This model makes it possible to more precisely rubricate unstructured electronic text documents under conditions of interconnected rubrics and to increase the efficiency of document processing.
Germination of Chloris barbata, Cynodon dactylon, and Cyperus rotundus from Angola at Constant and Alternate Temperatures

The study of weed germination can improve knowledge on their seasonal dynamics in fields and facilitate the design of ecologically sustainable management. An experiment was conducted to evaluate the effect of a range of constant and alternate temperatures on the germination of Chloris barbata, Cynodon dactylon, and Cyperus rotundus collected in Angola. Interesting differences were observed between the germination responses of the three species. No germination was observed for any species at 10 or 15–5 °C. Chloris barbata quickly germinated at most constant and alternate incubation temperatures, showing low primary dormancy and high germinability. Fast and high germination was observed for Cynodon dactylon at most alternate temperatures, while lower germination percentages were achieved at constant temperatures, especially the highest ones. Cyperus rotundus achieved good germination percentage at alternate temperatures, even if with slower and more extended germination dynamics than the other species, while almost no seeds germinated at constant temperatures. This study improves our knowledge of germination ecology for these species and allows some control tools to be identified, such as soil tillage, cover crops, and living or dead mulches, which can contribute to their ecologically sustainable management.
Financial Constraints, Firms’ Investments and Performance of Manufacturing Sector of Pakistan: A Cross Industry Analysis

This study aims to examine the impact of financial constraints on firms’ investments across different industries of manufacturing sector of Pakistan. The main objective is to investigate whether investment-cash flows sensitivity varies across financially constrained and unconstrained industries and to explore how it effects the overall performance of manufacturing sector. For this purpose, textile, chemical, engineering and sugar and allied industries are studied to perform a cross industry analysis to explore either sensitivity of firms’ investment to internal finance varies across different industries. This study uses panel data and applied Generalised Methods of Moments (GMM) for estimation. Empirical results indicate that firms’ financial decisions have influencing role in determining their investment activities and each industry behaves differently according to Financial conditions. Firms need to maintain their financial health to avoid any shock to internal finance that impact their investment spending. Moreover, investment opportunities are present for all industries except Engineering industry. The investments of Sugar and allied and Textile industry are constrained by internal finance as investment-cash flow sensitivity is positive for these industries. While Engineering and Chemical industries are explored to be facing no obstacles regarding finance accumulation for investments. It is apparent that textile industry is engaged in dealing with the financial constraints whether internally or externally. The observed conclusions confirmed that the growth of manufacturing sector and industrial development is affixed with the performance of major contributing industries hence, such policies should be implemented that enhance overall performance of industries.
Importance of atomic force microscopy settings for measuring the diameter of carbon nanotubes

Carbon nanotubes (CNTs) have gathered a lot of interest because of their extraordinary mechanical, electrical and thermal properties and have potential applications in a wide variety of areas such as material reinforcement and nano-electronics. The properties of nanotubes are dependent on their diameter and methods for determining this using atomic force microscopy (AFM) in tapping mode assume that the measured height of the tubes represent the real diameter. Based on early, faulty calculations, the forces in tapping mode were assumed to be much lower than in contact mode, however it was later shown that forces in tapping mode can at point of impact rival the forces present in contact mode. This means that there is a potential risk of tube deformation during tapping mode measurements, resulting in incorrectly determined diameters. This work studies CNTs deposited on a silicon-substrate to analyze the effect of three common AFM settings (tapping frequency, free oscillation amplitude and setpoint) to determine their effect on measured CNT diameters and recommendations for choosing settings are given.
Profiling Youth Participation in Volunteer Activities in Malaysia: Understanding the Motivational Factors Influencing Participation in Volunteer Work among Malaysian Youth

The involvement of youth in volunteer work is essential as it enables them to contribute to society (Checkoway, 2011). However, profile studies on Malaysian youth participation in volunteer activities are scarce and the subject warrants further research (Siti Raba’ah et al., 2011; Turiman et al., 2009). What is the level of participation of youth in volunteer activities? What hinders or motivates them to participate in volunteering work? This research profiles youth participation in volunteer activities in Malaysia. Specifically, it is aimed at profiling: 1) factors that motivate youth to participate in volunteer work; 2) the level of motivation towards participation in volunteer work among Malaysian youth; and 3) the most dominant motivation factor of youth participation in volunteer work. A total of 342 Malaysian youths participated in this nationwide study. A Youth Motivation on Participation in Volunteering Questionnaire was administered to Malaysian youth. Data were analysed and interpreted to provide the key findings on Malaysian youth engagement and participation in volunteer work. This study shows that the relationship between motivation and participation in volunteer work is positively significant. It shows that almost all the respondents in this study participating in voluntary activities were influenced by a number of motivating factors. The study ends with recommendations for policy makers and practitioners on how to attract youth to participate and to engage more effectively in volunteer work.
PREVALENCE OF DIABETES MELLITUS ON MALE AND FEMALE PATIENT OF DIFFERENT AGE GROUP ON HOSPITAL BASED DATA OF CHITWAN MEDICAL COLLEGE TEACHING HOSPITAL

Diabetes mellitus is a metabolic disorder and a major health problem of all countries. It is estimated that in 2010 there were globally 285 million people (approximately 6.4% of the adult population) suffering from this disease. This number is estimated to increase to 430 million by 2030. Information regarding the diabetes incidence of different age group and gender in the inhabitants of Chitwan is very high. Diabetic profile tests were performed using blood sugar fasting (BSF), blood sugar random (BSR), blood sugar post prandial (BSPP) and HBA1C in the patients who visited OPD of CMCTH, a tertiary care teaching hospital in the central region of Nepal. Out of the 10,665 surveyed subjects, only 584 subjects (5.47%) between the age group 30-70, [males: 53.6% (n=313)] and [females: 46.4% (n=271)] were confirmed diagnosed of having diabetes on the basis of WHO and ADA diagnostic criteria. All the parameters of diabetic profile tests estimation in patients were significantly higher (p<0.005) than that of normal individuals. Key words: Diabetes mellitus, Blood sugar and HBA1C.
Selection of reference genes for RT-qPCR analysis in the bark of Populus yunnanensis cuttings Journal of Environmental Biology

Cuttings of Populus yunnanensis were cultured in water by two ways, upright and inverted vertically. Different internode barks were collected as test materials from 0 day to 49 day, once in seven day. Upright samples (U) and inverted samples (I) are two different conditions, total samples (U + I) means the third condition. Seven candidate reference genes (PD-E1, TUA2, UBQ, ACT2, TUB, HIS and 18S RNA) were amplified by RT-qPCR. geNorm, NormFinder, BestKeeper and RankAggreg programs were used to select and evaluate the stability of seven candidate reference genes under three different conditions.