Miracle-dz/UniFAR-FTUs huggingface dataset:
(3,4-Dimethoxyphenyl)[2-(thiophen-2-ylcarbonyl)phenyl]methanone

In the title compound, C20H16O4S, the thiophene ring makes dihedral angles of 72.9 (2) and 60.5 (2)°, respectively, with the dimethoxy benzene and phenyl rings. In the crystal, C—H⋯O hydrogen bonds link the molecules into a C(9) chain along the b axis. The S and C atoms of the thiophene ring are disordered over two sets of sites [site occupancies = 0.675 (3) and 0.325 (3)]. A short intermolecular S⋯O contact [3.084 (2) Å] is observed in the crystal structure, which also features C—H⋯π interactions.
(RS)-(2-Bromo-4-fluoroanilino)[2-(4,6-dimethoxypyrimidin-2-yloxy)phenyl]acetonitrile

In the title compound, C20H16BrFN4O3, the pyrimidine and 2-bromo-4-fluorophenyl rings are twisted away from the central benzene ring, making dihedral angles of 77.7 (1) and 85.5 (1), respectively. A pair of C—H⋯F interactions is involved in an R 2 2(8) motif, linking the molecules into dimers. These ring motifs are situated about the crystallographic centres of symmetry. C—H⋯O hydrogen bonds link the dimers into chains running parallel to [11]. Additionally, a weak C—F⋯π-electron ring interaction was observed in the crystal packing [F⋯Cg = 3.459 (4) Å; Cg is the centroid of the pyrimidine ring]. There is also an intramolecular N—H⋯Br interaction in the structure.
Current Status of Metacarpophalangeal Joint Arthroplasty

Metacarpophalangeal (MCP) joint arthroplasty is commonly performed for rheumatoid affection of hand. Functional realignment of joint and deformity correction is the principal gain; improving the outcome. Improved understanding of anatomy, pathophysiology and mechanics of MCP joint has provided better insights for patient evaluation and surgical techniques for arthroplasty. Even with high rates of implant failure in long term the clinical impact remains minimal. MCP arthroplasty done for proper indications and with adequate soft tissue reconstruction has a high rate of patient satisfaction.
5-Hydroxy-7-methoxy-4H-chromen-4-one

The molecular conformation of the title compound, C10H8O4, isolated from Laretia acualis, is stabilized by a strong intramolecular hydrogen bond between the hydroxyl and carbonyl groups. The crystal packing shows π–π stacking interactions. The chromene (4H-1-benzopyran-4-one) unit is essentially planar.
1,6-Bis(p-tolyloxy)hexane

The title compound, C20H26O2, crystallized with one half-molecule in the asymmetric unit. The whole molecule is generated by inversion symmetry, with the center of inversion being situated at the mid-point of the central –CH2—CH2- bond of the bridging hexane chain. In the crystal, molecules stack in columns along the b axis. C—H⋯π interactions are present within the columns.
Self-reported physical activity and the risk of breast cancer

Introduction . The majority of epidemiologic studies suggest that physically active women are at a lower risk of developing breast cancer than physically inactive women. Few of these studies, however, have examined the association between the risk of breast cancer and the lifetime physical activity from all sources. The aim of this paper is to investigate the effect of lifetime physical activity from occupational activity, household and outdoor tasks, and recreational activity in different periods of life (14-20, 21-34, 35-50, and after the age of 50 years), on the incidence of breast cancer. Material and methods . This case-control study of 250 women with histologically confirmed breast cancer, operated between 1999 and 2003 and 301 controls free of any cancer diagnosis, aged 35-75 years, living in the region of Western Pomerania was conducted to evaluate this relationship. Self-reported intensity of the types of activities listed above, as well as information on recognized and other potential risk factors of breast cancer were obtained using a self-administered questionnaire. The relationship between physical activity and the risk of breast cancer was assessed using logistic regression and controlling for potential confounders. Results . After adjustment for age and other potential confounders, the risk of breast cancer was approximately 54% lower among women who regularly exercised at moderate or high intensity in childhood and adolescence (period of 14-20 years) (odds ratio (OR)=0.46; 95% confidence interval (CI)=0.27-0.84). A linear decrease in the risk of breast cancer was observed with increasing physical exertion (Ptrend=0.002). Compared with inactive and low activity women, those who reported that their lifetime household and outdoor tasks (e.g. garden activity) required moderate or vigorous exertion had a decreased risk of breast cancer development (OR=0.64, 95% CI=0.41-1.01, p=0.05). In case of a lifetime occupational physical activity, the multivariate OR for the highest versus the lowest level of intensity was increased, but not statistically significantly (OR=1.46, 95% CI=0.75-2.81; P for trend =0.28). Conclusion . The data presented provides additional evidence that increased recreational physical activity, especially in childhood and adolescence, reduces breast cancer risk. In addition, this study shows that household activity - a major source of energy expenditure, rarely assessed carefully and included in the analysis of the physical activity - breast cancer relation by other authors has a protective effect against breast cancer in moderate and vigorous active women. More studies with a larger sample of women are needed to confirm these associations and to determine which types of physical activity or levels of its intensity performed at various time periods in a woman's life can prevent breast cancer or reduce its risk.
2-Methoxy-9-phenoxyacridine

The molecules in the crystal structure of the title compound, C20H15NO2, form inversion dimers connected through the C—H⋯N and π–π interactions. These dimers are further linked by C—H⋯π interactions. The methoxy group is nearly coplanar with the acridine ring system [dihedral angle = 4.5 (1)°], whereas the phenoxy fragment is nearly perpendicular to it [dihedral angle = 85.0 (1)°]. The mean planes of the acridine ring systems are either parallel or inclined at angles of 14.3 (1), 65.4 (1) and 67.3 (1)° in the crystal.
1-Acetyl-3-(4-chlorophenyl)-5-(4-fluorophenyl)-2-pyrazoline

In the title molecule, C17H14ClFN2O, the mean plane of the pyrazoline ring makes dihedral angles of 18.19 (1) and 83.51 (4)° with the 4-chlorobenzene and 4-fluorobenzene rings, respectively. The two benzene rings make a dihedral angle of 76.11 (2)°. Weak intermolecular C—H⋯O hydrogen bonds help stabilize the crystal structure.
Diiodidobis(N,N,N′,N′-tetramethylthiourea-κS)cadmium(II)

In the title compound, [CdI2(C5H12N2S)2], the CdII ion is located on a twofold rotation axis and is coordinated in a distorted tetrahedral mode by two iodide ions and by two tetramethylthiourea (tmtu) ligands through their S atoms. The crystal structure is stabilized by C—H⋯N and C—H⋯S hydrogen bonds.
False-Negative 18F-FDG PET Results in Lymph Node Metastasis of A Patient with Follicular Thyroid Carcinoma: A Case Report and Literature Review

Positron emission tomography (PET) with fluorine-18 fluorodeoxyglucose (18F-FDG) is a noninvasive functional imaging technique that provides information of the tissue metabolism with high accuracy in detecting various malignancies. 18F-FDG is not a cancer-specific agent, and false-positive results have been reported. However, false-negative results of 18F-FDG PET scan in diagnosis of malignant disease were rarely reported. We report a case of false-negative result of 18F-FDG PET scan in lymph node metastasis in a patient with follicular thyroid carcinoma.
1-(3,5-Dimethoxybenzyl)-1H-pyrrole

The title compound, C13H15NO2, was synthesized from 3,5-dimethoxybenzaldehyde. The dihedral angle between the pyrrole and benzene rings is 89.91 (5)°. In the crystal, weak C—H⋯O and C—H⋯π interactions link the molecules into a three-dimensional network.
Background on animal testing in the drug delivery systems program.

: In the screening and selection of candidate long-acting narcotic antagonist preparations, careful consideration must be given to the choice of animal evaluation models. A simple, rapid method, using analgesia suppression in the mouse tail-flick test, was chosen for preliminary screening. Suitable candidates were then evaluated by following urinary excretion rates and blood levels in the monkey. Afterwards, the most promising preparations were rigorously tested in their ability to interfere with morphine self-administration in monkeys. Final evaluation involved toxicological studies in injection sites and on the whole animal.
The relationship between Humor and Group productivity An exploratory study

Humor is an important factor in group dynamics. Based on humor literature from several fields, humor was predicted to have a positive effect on group productivity. An experiment was conducted to determine if humor can be induced and if it has a positive effect on group productivity. The results indicate that humor can be induced and increase a group's humor use. However, groups with people who used more humor were not more productive. Men in general and younger participants used humor more than women and older participants. Suggestions are offered for researchers interested in using experiments to test the effect of humor on groups.
4-[(4-Methylphenyl)sulfanyl]butan-2-one

In the title compound, C11H14OS, all non-H atoms are essentially coplanar, with a mean deviation of 0.023 Å. In the crystal, centrosymmetrically related molecules are weakly connected into dimers by pairs of C—H⋯O interactions. The dimers are further linked along the a axis by weak C—H⋯π and C—H⋯S interactions.
Effects of touch on agitation in patients under mechanical ventilation

Introduction: Patients following mechanical ventilation go down to agitation due to anxiety, stress and stimulation of tracheal tube, that may be treat in doing of mechanical ventilation processes and can be create dyspnea, confusion and inability. Control of agitation with drug and physical restrictions have much unpleasant complication. Therefore, the aim of this study was to determine the effect of touch on agitation in patients under mechanical ventilation. Materials and Methods: The semi-experimental research was performed in a general intensive cares unit in a hospital in Tehran in 2011. The data collection tools were including demographic questionnaire, Glasgow coma scale and Richmond agitation score scale. 35 consciousness patients under mechanical ventilation with 30-60 years old and acute respiratory problems were investigated. Firstly, the patient's agitation was evaluated and then intervention performed in two ways:(a) with standing and touching patient's wrist and (b) with standing without touching of patient's wrist. Results: From 35 patients, 21 (60%) and 14 (40%) were respectively men and female. Minimum and maximum age was respectively 35 and 60 years. Most of the patients were ranged in the age group of 50 years or more (57.1%) and then 40 to 49 years group (17.2%) and 25.7% of the patients were under 40 years old. In standing without touching patient's wrist intervention, agitation scores before and after intervention had no significant difference (P=0.592), while as, with standing and touching patient's wrist intervention this difference was significant (P<0.001). Conclusion: According to the results of this study, touch is effective on agitation in patients under mechanical ventilation. Therefore, touch is recommended as safe and effective non-pharmacological interventions in controlling agitation in the field of independent nursing jobs. Keywords: Touch, Agitation, Mechanical ventilation, Patients
Design and implementation of a Neonatal Tissue Viability Assessment Tool on the newborn intensive care unit

Pressure ulcers can be a cause of considerable discomfort and morbidity for patients and so their prevention is high on the agenda of most nurses. The importance that nurses place on skin integrity is highlighted by the inclusion of pressure sore prevention in the Chief Nursing Officers ‘High Impact Nursing Actions’. It is generally accepted that in the adult population the majority of pressure ulcers that develop in NHS-provided care are avoidable. There are a number of assessment tools utilised to assess those patients at risk but these are mostly focused within the adult and child population. There is little validated data available for assessment of neonatal tissue viability and yet because of the vulnerable nature of this group of patients they are at potential risk of pressure damage to their fragile skin. On NICU the staff were very keen to improve the quality of patient care by delivering nursing interventions which would bring a clear benefit to the infants. Although nursing guidelines for the care of skin in preterm infants were already available the NICU Clinical Practice Group identified that a standardised tool for the assessment of skin integrity would help nursing staff to objectively assess risk and plan appropriate interventions. This is particularly important when nursing staff are junior. The aim of this project was to devise a tissue viability assessment tool which would accurately assess the potential for skin damage in newborn infants with a range of gestational ages. The team utilised the ‘Plan Do Study Act’ (PDSA) methodology of achieving service Design and implementation of a Neonatal Tissue Viability Assessment Tool on the newborn intensive care unit
Comparison between psychometric characteristics of persian version of the gastrointestinal symptoms rating scale in functional gastrointestinal disorders and normal groups.

Background : The purpose of this study was to determine reliability and construct validity of a Persian version of the Gastrointestinal Symptoms Rating Scale (GSRS) in 2 samples of patients with functional gastrointestinal disorders (FGID) and healthy persons. Materials and Methods : The clinical sample consisted of 143 patients diagnosed with FGID who were referred to the Psychosomatic Disorders Clinic. Controls consisted of 108 healthy individuals (without digestive diagnoses) matched by age, gender, marital and educational status. Results : The results of the factor structure or construct validity that used the principal components analysis with varimax rotation was 4 factors of diarrhea, abdominal pain, constipation, and indigestion in patients with FGID, which showed a 61.53 variance. Among the 6 factors of indigestion, abdominal pain, constipation, diarrhea, hungry pain, and nausea in healthy persons there was a 73.32 variance. Reliabilities of the GSRS and its dimensions were satisfactory with Cronbach-Alpha. Conclusion : The Persian version of the GSRS has favorable reliability and validity.
Automated Correction and Optimized Contrast Enhancement of Multi-Line CCD Images

I am submitting herewith a dissertation written by Zhiyu Chen entitled " Automated Correction and Optimized Contrast Enhancement of Multi-Line CCD Images ". I have examined the final electronic copy of this dissertation for form and content and recommend that it be accepted in partial fulfillment of the requirements for the degree of Doctor of Philosophy, with a major in Electrical Engineering. (Original signatures are on file with official student records.) DEDICATION I would like to dedicate this dissertation to my parents, Fangjun Chen and Qiying Zhang, who were research nuclear engineers and devoted most of their professional life to the thermal plasma nuclear fusion research program of China. I would like to thank them for giving me the gifted talent in science and technology and their influences on me in those fields, and their unconditional support of my own decision on choosing my life path. iv ACKNOWLEDGMENTS
Detection of α2-Adrenergic Receptors in Brain of Living Pig with 11C-Yohimbine

UNLABELLED There have been few radiotracers for imaging adrenergic receptors in brain by PET, but none has advanced for use in human studies. We developed a radiosynthesis for the alpha(2)-adrenergic antagonist (11)C-yohimbine and characterized its binding in living pigs. As a prelude to human studies with (11)C-yohimbine, we determined the whole-body distribution of (11)C-yohimbine and calculated its dosimetry. METHODS Yorkshire x Landrace pigs weighing 35-40 kg were used in the study. Baseline and postchallenge PET recordings of (11)C-yohimbine in pig brain were conducted for 90 min, concurrent with arterial blood sampling, and with yohimbine and RX821002 as pharmacologic interventions. (15)O-Water scans were performed to detect changes in cerebral perfusion. The PET images were manually coregistered to an MR atlas of the pig brain. Maps of the (11)C-yohimbine distribution volume ([V(d)] mL g(-1)) in brain were calculated relative to the arterial input function. RESULTS Whole-body scans with (11)C-yohimbine revealed high accumulation of radioactivity in kidney, intestine, liver, and bone. The estimated human dose was 5.6 mSv/GBq, a level commonly accepted in human PET studies. Brain imaging showed baseline values of V(d) ranging from 1.9 in medulla, 3.0 in cerebellum, and to 4.0 in frontal cortex. Coinjection with nonradioactive yohimbine (0.07 mg/kg) reduced V(d) globally to approximately 1.5-2 mL g(-1). A higher yohimbine dose (1.6 mg/kg) was without further effect on self-displacement. Very similar results were obtained by displacement with the more selective alpha(2)-adrenergic antagonist RX821002 at doses of 0.15 and 0.7 mg/kg. Cerebral blood flow was globally increased 43% after administration of RX821002. Notable features of (11)C-yohimbine are a lack of plasma metabolism over 90 min and a rapid approach to equilibrium binding in brain. CONCLUSION The new radiotracer (11)C-yohimbine seems well suited for PET investigations of alpha(2)-adrenergic receptors in brain and peripheral structures, with the caveat that displaceable binding was present in cerebellum and throughout the brain.
1-(3-Chlorobenzyloxy)urea

The asymmetric unit of the crystal structure of the title compound, C8H9ClN2O2, contains four independent molecules. The dihedral angles between the urea N—(C=O)—N planes and the benzene rings are 83.3 (3), 87.8 (1), 89.1 (1) and 17.5 (2)° in the four molecules. Extensive N—H⋯O hydrogen bonding is present in the crystal structure.
3,4,5-Trimethoxy-N-(2-methoxyphenyl)benzamide

In the title molecule, C17H19NO5, the amide plane is oriented at an angle of 41.5 (3)° with respect to the 2-methoxybenzene ring. The three methoxy groups lie almost in the plane of the aromatic rings to which they are attached [C—O—C—C torsion angles of of 0.7 (4), −13.4 (4) and 3.1 (4)°], whereas the methoxy group at the 4-position of the 3,4,5-trimethoxybenzene ring is nearly perpendicularly oriented [C—O—C—C torsion angle of 103.9 (3)°]. In the crystal structure, intermolecular N—H⋯O hydrogen bonds link the molecules into chains along [001].
4-{[1-(4-Ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]diphenylmethyl}morpholine

The title compound, C28H30N4O2, synthesized from 4-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]diphenylmethanol and morpholine, consists of a subsituted triazolyl group and a morpholinyl group that crowd the aliphatic C atom of a diphenylmethyl unit [Ctriaz—C—Nmorph = 110.1 (1)° and Cphenyl—C—Cphenyl = 103.9 (1)°]. The morpholine ring adopts a chair conformation.
4-[(4-Methylbenzyl)amino]-3-[(4-methylbenzyl)iminomethyl]-2H-chromen-2-one

The title compound, C26H24N2O2, was prepared from the reaction of 4-chloro-3-formylcoumarin with p-methylbenzylamine. Even though there are no strong and specific interactions in the crystal structure, the translationally related molecules form chains along the b axis. The coumarin moieties are stacked through π–π interactions [centroid–centroid distance = 3.5275 (7) Å], forming layers perpendicular to the stacking direction.
2,6-Dichloro-N-(4-chlorophenyl)benzamide

In the title compound, C13H8Cl3NO, the dihedral angle between the benzene rings is 63.2 (2)°. In the crystal, N—H⋯O hydrogen bonds link the molecules into C(4) chains propagating in [001]. Weak aromatic π–π stacking also occurs [centroid–centroid separations = 3.759 (3) and 3.776 (3) Å].
Chronic idiopathic urticaria, gastrointestinal symptoms and Helicobacter pylori infection

Chronic idiopathic urticaria (CIU) is one of the most persistent and distressing skin diseases and the only treatment available is symptomatic in the form of H 1 blockers and systemic steroids in severe cases. Chronic infections have always been implicated in the causation of chronic urticaria. The presence of associated gastrointestinal symptoms in a sizable percentage of patients of chronic urticaria as well as the chronic and asymptomatic nature of Helicobacter pylori infection make the possibility of an association between chronic urticaria and H. pylori infection a biologically plausible one. In the present study sixty patients of chronic idiopathic urticaria were evaluated along with an equal number of age and sex matched controls for presence of H. pylori infection by means of an ELISA-based serological test. All seropositive patients were then given eradication treatment for H. pylori infection and monitored for any improvement in signs and symptoms. The overall H. pylori seropositivity was found to be 60% in cases as compared with only 31.6% in control group. Furthermore, there was an overall response rate of 58% in those patients who were treated by H. pylori eradication therapy.
Sensitivity and Specificity of the Self-Report Adolescent Health Screening Tool in Identifying Mental Health Problems among Adolescents.

This study was done to validate the mental health component of the locally used Adolescent Health Screening Form (Borang Saringan Kesihatan Remaja, BSSK/R/1/2008). This screening tool is used at the primary care levels for adolescent clients. The mental health component of this screening tool was used to screen for depression, anxiety and suicidal tendency. Three validated tools was used in the validation process namely: 6-item Kutcher Adolescent Depression Scale: KADSfor screening of depression problem, Beck Anxiety Inventoryfor screening of anxiety problem and Tool for Assessment of Suicide Risk: Adolescent Version (TASRS-A) for screening of suicidal risk. This Adolescent Health Screening Tool was found to be very sensitive (100%) and specific (79.0%) in detecting anxiety disorders, and very specific (98.8%) but less to moderate sensitivity (28.6% and 54.5% respectively) in detecting depression and suicidal risk.
Kingella kingae: from asymptomatic colonization to invasive pediatric infections

As a result of the use of blood culture vials for seeding joint and bone exudates, and the development of nucleic acid amplification methods, Kingella kingae is being increasingly recognized as an emerging invasive pathogen and the most common etiology of septic arthritis in children aged 6–36 months. K. kingae is carried asymptomatically in the pharynx, and is transmitted from child-to-child by close contact between family members and playmates. K. kingae organisms enter the bloodstream through breaches in the respiratory mucosa and disseminate to remote sites. Skeletal system infections are the most common presentations of K. kingae disease, followed by bacteremia, pneumonia and endocarditis. Children with invasive K. kingae infections frequently show a mild clinical picture and normal acute-phase reactants, requiring a high index of suspicion. The organism is usually susceptible to antibiotics and, with the exception of endocarditis cases, most patients promptly respond to adequate antimicrobial therap.
3-Methyl-5-phenoxy-1-phenyl-1H-pyrazole-4-carbaldehyde

In the title compound, C17H14N2O2, the pyrazole ring makes dihedral angles of 73.67 (4) and 45.99 (4)°, respectively, with the adjacent phenyl and phenoxy rings. In the crystal, there are no classical hydrogen bonds, but a weak C—H⋯π interaction is observed.