Miracle-dz/UniFAR-FTUs huggingface dataset:
Reductions in Herpes Simplex Virus Type 2 Antibody Titers After Cognitive Behavioral Stress Management and Relationships With Neuroendocrine Function, Relaxation Skills, and Social Support in HIV-Positive Men

Objective Coinfection with herpes simplex virus type 2 (HSV-2) is common in individuals infected with human immunodeficiency virus (HIV) and may have health implications. This study examined the effect of a 10-week cognitive behavioral stress management (CBSM) intervention on immunoglobulin G (IgG) antibody titers to HSV-2 in a group of mildly symptomatic HIV-infected gay men and the degree to which these effects were mediated by psychosocial and endocrine changes during the 10-week period. Methods Sixty-two HIV+ gay men were randomly assigned to either a 10-week CBSM intervention (N = 41) or a wait-list control condition (N = 21). Anxious mood, social support, cortisol/dehydroepiandrosterone sulfate (DHEA-S) ratio levels, and HSV-2 IgG antibody titers were assessed at baseline and after the 10-week period. CBSM participants also recorded their stress levels before and after at-home relaxation practice. Results HSV-2 IgG titers were significantly reduced in the CBSM participants but remained unchanged in the control group after the 10-week intervention period. Increases in one type of social support, perceived receipt of guidance, during the 10 weeks was associated with and partially mediated the effect of the intervention on HSV-2 IgG. Similarly, decreases in cortisol/DHEA-S ratio levels were associated with decreases in HSV-2 IgG, and lower mean stress levels achieved after home relaxation practice were associated with greater decreases in HSV-2 IgG among CBSM participants. Conclusions These findings suggest that behavioral and psychosocial changes occurring during CBSM interventions, including relaxation, enhanced social support, and adrenal hormone reductions, may help to explain the effects of this form of stress management on immune indices such as HSV-2 antibody titers.
Infiltrating lobular carcinoma of the breast: An evaluation of the incidence and consequence of bilateral disease

A histological review of 1003 invasive breast carcinomas identified 103 patients with infiltrating lobular carcinoma, for whom clinical and survival data were collected in each case. Six patients had bilateral carcinoma at diagnosis and 14 developed a contralateral carcinoma during the period of follow‐up. The major factor predicting patients at risk of developing a contralateral carcinoma was histological type. Analysis of survival data on the patients with bilateral disease showed poor survival in the group with synchronous bilateral disease, but no difference in survival between patients with metachronous bilateral and unilateral disease. This suggests that the development of a metachronous contralateral carcinoma does not necessarily reduce the probability of survival of patients with infiltrating lobular carcinoma.
Comparison of Maximal Aerobic Speed as Assessed with Laboratory and Field Measurements in Moderately Trained Subjects

In order to compare the Maximal Aerobic Speed (MAS) evaluated with different methods, eleven male physical education students (22.2 +/- 3.0 years) were submitted to a maximal treadmill protocol and to the Université de Montréal Track Test (UMTT). Four methods were used to calculate MAS. After treadmill measurement of VO2max, MAS was calculated (MAS_calc) by the following formula: MAS_calc = (VO2max - 0.083)/C, where VO2max is the maximal oxygen uptake (ml.kg-1.s-1) and C the energy cost of running (ml.kg-1.m-1). The extrapolated MAS (MAS_ex) was obtained from the measured VO2max and by extrapolation of the VO2 versus speed relationship. The MAS for treadmill measurement (MAS_tr) and for UMTT (MAS_UMTT) were the velocities at the last completed stages. The average MAS_calc (4.71 +/- 0.48 m.s-1), MAS_ex (4.62 +/- 0.48 m.s-1), MAS-tr (4.75 +/- 0.57 m.s-1) and MAS_UMTT (4.64 +/- 0.35 m.s-1) were not significantly different and were significantly correlated, between 0.85 (MAS_ex vs MAS_UMTT) and 0.99 (MAS_calc vs MAS_tr), with p < 0.001 in both cases. MAS measurements were significantly correlated to measured VO2max but independent of C.
A novel singly fed wideband circularly polarized cylindrical multilayer DRA using conformal hook-shaped metal strip

A unique hook-shaped conformal metal strip has been used to excite a cylindrical multilayer dielectric resonator antenna (DRA). By using the proposed unique feed and multi dielectric layers, a broadband circular polarization have been achieved over a bandwidth of ∼9.8% in conjunction with an impedance-matching bandwidth of ∼12.8% at same frequency range. The DRA has been successfully designed and excited by using computer simulation technology (CST), a 3D simulation tool. The antenna prototype has been designed and simulated using Finite Integration Technique (FIT). The results have been validated by using different simulation technique i.e. Finite Element Method (FEM). A good agreement between the results from FIT and FEM has been achieved which guarantees the validity of the proposed design.
Cancer--nature, nurture, or both.

The relative roles of genetic constitution and environmental exposure in the causation of cancer have been debated for decades.1 Geographic differences, trends over time in the risk of cancer, and detailed studies of migrant populations overwhelmingly implicate environmental exposures as major causal factors and often identify the responsible carcinogens (e.g., tobacco, alcohol, radiation, occupational toxins, infections, diet, drugs). From this work has come the widely accepted estimate that 80 to 90 percent of human cancer is due to environmental factors.2 Yet in the past 15 years, the explosion of molecular genetics has overshadowed environmental explanations by revealing genetic mechanisms underlying .
Molecular Analysis of Healing at a Bone-Implant Interface

While bone healing occurs around implants, the extent to which this differs from healing at sites without implants remains unknown. We tested the hypothesis that an implant surface may affect the early stages of healing. In a new mouse model, we made cellular and molecular evaluations of healing at bone-implant interfaces vs. empty cortical defects. We assessed healing around Ti-6Al-4V, poly(L-lactide-co-D,L,-lactide), and 303 stainless steel implants with surface characteristics comparable with those of commercial implants. Our qualitative cellular and molecular evaluations showed that osteoblast differentiation and new bone deposition began sooner around the implants, suggesting that the implant surface and microenvironment around implants favored osteogenesis. The general stages of healing in this mouse model resembled those in larger animal models, and supported the use of this new model as a test bed for studying cellular and molecular responses to biomaterial and biomechanical conditions.
Addressing the 'Risk Environment' for Injection Drug Users: The Mysterious Case of the Missing Cop

Ecological models of the determinants of health and the consequent importance of structural interventions have been widely accepted, but using these models in research and practice has been challenging. Examining the role of criminal law enforcement in the "risk environment" of injection drug users (IDUs) provides an opportunity to apply structural thinking to the health problems associated with drug use. This article reviews international evidence that laws and law enforcement practices influence IDU risk. It argues that more research is needed at four levels--laws; management of law enforcement agencies; knowledge, attitudes, beliefs, and practices of frontline officers; and attitudes and experiences of IDUs--and that such research can be the basis of interventions within law enforcement to enhance IDU health.
Tmem27 is upregulated by vitamin D in INS-1 cells and its serum concentrations are low in patients with autoimmune diabetes

Abstract Transmembrane protein 27 (Tmem27), which is expressed in pancreatic β-cells, plays an important role in insulin secretion and pancreatic β-cell proliferation. Analysis of the INS-1 cell proteome using stable isotope labeling by amino acids in cell culture (SILAC) in combination with LC-MS identified Tmem27 as the one of most robustly (up to seven-fold) upregulated proteins after treatment with the active metabolite of vitamin D, 1,25-(OH)2D3. Furthermore, we report that Tmem27 which is cleaved and released from, i.e. pancreatic β-cells, is present in human serum and its levels are significantly lower in subjects with autoimmune diabetes as compared to healthy individuals (13% of the levels). Additionally, Tmem27 correlated positively (0.70) with C-peptide serum levels in healthy subjects. Our data indicate that Tmem27 could be of potential value as a serum marker for the pathogenesis of diabetes and as such may warrant the development of measurement methods with lower limit of detection for its further validation.
EIGENVALUES OF CONES IN THE SMALL APERTURE LIMIT T

We are interested in finite cones of fixed height 1 parametrized by their opening angle. We study the eigenpairs of the Dirichlet Laplacian in such domains when their apertures tend to 0. We provide multi-scale asymptotics for eigenpairs associated with the lowest eigenvalues of each fiber of the Dirichlet Laplacian. In order to do this, we investigate the family of their one-dimensional Born-Oppenheimer approximations. The eigenvalue asymptotics involves powers of the cube root of the aperture, while the eigenfunctions include simultaneously two scales.
A chemical level in the coevolutionary arms race between an ant social parasite and its hosts

Here we investigate the coevolutionary interactions between the slavemaking ant Protomognathus americanus and its Temnothorax hosts on a chemical level. We show that, although this social parasite is principally well‐adapted to its hosts’ cuticular hydrocarbon profile, there are pronounced differences in the fine‐tuning of this adaptation. Between populations, chemical adaptation varies with host community composition, as the parasite faces a trade‐off when confronted with more than one host species. In addition to adaptation of its own chemical signature, the slavemaker causes a reciprocal adjustment in its slaves’ cuticular profile, the degree of which depends on the slave species. On the host side, successful parasite defence requires efficient enemy recognition, and in behavioural aggression trials, host colonies could indeed discriminate between invading slaves, which commonly accompany slavemakers on raids, and free‐living conspecifics. Furthermore, hosts shifted their acceptance threshold over the seasons, presumably to reduce the costs of defence.
Mass migration of a group I intron: promiscuity on a grand scale.

To date, most studies of group I intron mobility have dealt with intraorganismal transfer occurring between intron+ and intron− alleles of particular genes during genetic crosses. Little is known about the frequency and extent of horizontal transfer of group I introns between organisms that do not mate. Most such identified cases involve transfer into the same genome (e.g., mitochondrial) in taxa that at least belong to the same phylum (see ref. 5). There is, however, one reported instance in which interphylum (and interorganellar) transfer of group I introns appears to have occurred (6). Even so, nothing remotely approaching the extraordinary intron radiation reported by Cho et al. in this issue of the Proceedings (5) has been documented previously.
Analytic input matching for millimeter wave LNA in 90nm CMOS technology

An analytic input matching technique for low noise amplifiers (LNA) has been presented. This method has been developed to design of cascode LNA for millimeter wave applications in modern CMOS technologies. Unlike the conventional analytic matching [1], the accurate transistor model used in our analysis, leads to acceptable accuracy in this frequency range. The analysis results have been used in design of a 30GHz LNA for STMicroelectronics 90nm digital CMOS process. Simulation in foundry design kit shows excellent accuracy of proposed method in comparison with the conventional method. The designed LNA have 10dB power gain with 5mW DC power consumption.
Prospective study of microchimerism in transplant recipients

Background. We evaluated peripheral blood microchimerism in 48 consecutive organ transplant recipients (35 kidneys, ten livers, one kidney–liver, one kidney–pancreatic islet, one kidney–pancreas) up to 12 months post‐transplantation. Patients were categorized according to the presence or absence of rejection episodes, and the patterns of microchimerism in the two groups were then compared.Methods. DNA was extracted from donor, pre‐transplant, and post‐transplant peripheral blood samples. Several polymerase chain reaction (PCR)‐based assays were developed for the detection of microchimerism. Assay sensitivities ranged from 0.0001 to 3%. Results. Microchimerism was detected only in sex‐mismatched cases (male donors and female recipients) using nested PCR for a Y‐chromosome marker. There were ten such cases (six kidneys, two livers, and two combined organ transplants). In patients without rejection (n=7), there was a peak of donor‐DNA at 1–3 wk post‐transplantation followed by a second peak between 3 wk and 4 months. In patients with biopsy‐proven rejection (n=3), the peaks were absent and the levels of microchimerism were extremely low (<0.001%). Microchimerism levels declined in all 10 patients and were barely detectable 1 yr post‐transplantation. Microchimerism was not detected in the remaining 38 patients despite using a battery of sensitive PCR‐based assays.Conclusions. In our study, microchimerism was detected using the Y‐chromosome PCR assay only and the level of donor‐DNA in a given patient varied over time. This study highlights the difficulties in establishing a correlation between microchimerism and transplant tolerance.
Volumetric and lateralized differences in selected brain regions of chimpanzees (Pan troglodytes) and bonobos (Pan paniscus)

The two species of Pan, bonobos and common chimpanzees, have been reported to have different social organization, cognitive and linguistic abilities and motor skill, despite their close biological relationship. Here, we examined whether bonobos and chimpanzee differ in selected brain regions that may map to these different social and cognitive abilities. Eight chimpanzees and eight bonobos matched on age, sex and rearing experiences were magnetic resonance images scanned and volumetric measures were obtained for the whole brain, cerebellum, striatum, motor‐hand area, hippocampus, inferior frontal gyrus and planum temporale. Chimpanzees had significantly larger cerebellum and borderline significantly larger hippocampus and putamen, after adjusting for brain size, compared with bonobos. Bonobos showed greater leftward asymmetries in the striatum and motor‐hand area compared with chimpanzees. No significant differences in either the volume or lateralization for the so‐called language homologs were found between species. The results suggest that the two species of Pan are quite similar neurologically, though some volumetric and lateralized differences may reflect inherent differences in social organization, cognition and motor skills. Am. J. Primatol. 71:988–997, 2009. © 2009 Wiley‐Liss, Inc.
Asymptotically optimal codebooks based on generalized Jacobi sums

Codebooks with small inner-product correlation are applied in many practical applications including direct spread code division multiple access communications, space-time codes and compressed sensing. It is extremely difficult to construct codebooks achieving the Welch or Levenshtein bound. In this paper, we firstly generalize Jacobi sums over finite fields and secondly obtain asymptotically optimal codebooks with respect to the Welch or Levenshtein bound. Our main results generalize those in [11] and the codebooks in this paper have more flexible parameters than those in [11].
Comparison of the Thermal Performance of the Multichip LED Packages

Single chip, 4-chip, and 16-chip light emitting diode (LED) packages were prepared to compare the thermal performance of the LED packages. Vertical type, GaN blue LED chips with alumina submount were used, and thermal transient analysis was conducted to investigate the thermal characteristics of the LED packages. Temperature sensitive parameter value was measured and the junction temperature was predicted. Thermal resistance between the p-n junction and the ambient was obtained from the structure function with the junction temperature evolution during the cooling period of LED. Junction temperature and thermal resistance were investigated with the change of input current level and compared for 1-chip, 4-chip, and 16-chip LED packages. The results showed that the junction temperature and the thermal resistance are strongly related to the number of the chips and the chip arrangement.
Membrane ion channels as physiological targets for local Ca2+ signalling

Ionized calcium plays a central role as a second messenger in a number of physiologically important processes determining smooth muscle function. To regulate a wide range of cellular activities the mechanisms of subcellular calcium signalling should be very diverse. Recent progress in development of visible light‐excitable fluorescent dyes with high affinity for Ca2+ (such as oregon green 488 BAPTA indicators, fluo‐3 and fura red) and confocal laser scanning microscopy provides an opportunity for direct visualization of subcellular Ca2+ signalling and reveals that many cell function are regulated by the microenvironment within small regions of the cytoplasm (‘local control’ concept). Here confocal imaging is used to measure and locate changes in [Ca2+]i on a subcellular level in response to receptor stimulation in visceral myocytes. We show that stimulation of muscarinic receptors in ileal myocytes with carbachol leading to activation of inositol 1,4,5‐trisphosphate receptors (IP3Rs) accelerates the frequency of spontaneous calcium sparks (discharged via ryanodine receptors, RyRs) and gives rise to periodic propagating Ca2+ waves oscillating with a frequency similar to that of carbachol‐activated cationic current oscillations. Furthermore, by combining the whole‐cell patch clamp technique with simultaneous confocal imaging of [Ca2+]i in voltage‐clamped vascular myocytes we demonstrate that calcium sparks may lead to the opening of either Ca2+‐activated Cl− channels or Ca2+‐activated K+ channels, and the discharge of a spontaneous transient inward current (STIC) or a spontaneous transient outward current (STOC), respectively.
Early results of patellofemoral inlay resurfacing arthroplasty using the HemiCap Wave prosthesis

Background: Common surgical treatment options for isolated patellofemoral osteoarthritis include arthroscopic procedures, total knee replacement and patellofemoral replacement. The HemiCap Wave patellofemoral resurfacing prosthesis is a novel inlay design introduced in 2009 with scarce published data on its functional outcomes. We aim to prospectively evaluate early functional outcomes and complications, for patients undergoing a novel inlay resurfacing arthroplasty for isolated patellofemoral arthrosis in an independent centre. Methods: From 2010 to 2013, 16 consecutive patients underwent patellofemoral resurfacing procedures using HemiCap Wave (Arthrosurface Inc., Franklin, Massachusetts, USA) for anterior knee pain with confirmed radiologically and/or arthroscopically isolated severe patellofemoral arthrosis. Standardized surgical technique, as recommended by the implant manufacturer, was followed. Outcome measures included range of movement, functional knee scores (Oxford Knee Score (OKS), Knee Injury and Osteoarthritis Outcome Score (KOOS) and Short Form-36 (SF-36)), radiographic disease progression, revision rates and complications. Results: Eight men and eight women underwent patellofemoral HemiCap Wave resurfacing, with an average age of 63 years (range: 46–83). Average follow-up was 24.1 months (6–34). Overall, post-operative scores were excellent. There was a statistically significant improvement in the post-operative OKS, KOOS and SF-36 scores (p < 0.01). One patient had radiological disease progression. One patient underwent revision for deep infection. Two other minor complications were observed and treated conservatively. Conclusions: The HemiCap Wave patellofemoral resurfacing prosthesis has excellent early results in terms of functional outcomes, radiological outcomes and low complication rates. At the very least, early results show that the HemiCap Wave is comparable to more established onlay prostheses. The HemiCap Wave thus provides a safe and effective surgical option in the treatment of isolated patellofemoral osteoarthritis in selected patients.
Design of a Secure Framework for the Implementation of Telemedicine , eHealth , and Wellness Services

In both developing and developed countries, the costs of delivering health care are increasingly taking a large proportion of the national gross domestic product (GDP). GDP, is one of several measures of the size of a regions’ economy. While developed countries have a good doctor to patient ratio, in developing countries the ratios are alarming (e.g., in Uganda it is about 1 doctor to 24.725 patients). Thus, with the advent of Information Communication Technologies (ICT), researchers are working on ways of using ICT to deliver health care services at low costs. This has led to the development of proprietary Telemedicine, Ehealth, and Wellness (TEW) systems. Because most developments are proprietary, standards are fluid and this rises questions about interoperability. Besides, the application of ICT to remotely collect and disseminate information in a sensitive domain like health care, rises a number of security related issues especially for TEW systems that rely on wireless sensor networks (WSNs) for data acquisition and transmission (i.e., questions about data confidentiality, system reliability, user authentication, and data integrity arise). Therefore, in this thesis we investigate a number of TEW systems, analyse their technologies and security implementations. Our investigation led us to conclude that most of the wireless sensor based TEW developments have focused on engineering issues of making the technology work at the expense of security. We learn that even those systems that have implemented good security mechanisms may not have modeled appropriate threats. Hence, we present a threat model of TEW-WSNs and propose a polynomial based key management scheme to secure TEW wireless sensor networks. We give conclusions about the application of TEW systems in developing countries and the future trends.