Miracle-dz/UniFAR-FTUs huggingface dataset:
Vaccination Coverage by Age 24 Months Among Children Born in 2015 and 2016 — National Immunization Survey-Child, United States, 2016–2018

The Advisory Committee on Immunization Practices (ACIP) recommends that children be vaccinated against 14 potentially serious illnesses during the first 24 months of life (1). CDC used data from the National Immunization Survey-Child (NIS-Child) to assess vaccination coverage with the recommended number of doses of each vaccine at the national, state, territorial, and selected local levels* among children born in 2015 and 2016. Coverage by age 24 months was at least 90% nationally for ≥3 doses of poliovirus vaccine, ≥1 dose of measles, mumps, and rubella vaccine (MMR), ≥3 doses of hepatitis B vaccine (HepB), and ≥1 dose of varicella vaccine, although MMR coverage was <90% in 20 states. Children were least likely to be up to date by age 24 months with ≥2 doses of influenza vaccine (56.6%). Only 1.3% of children born in 2015 and 2016 had received no vaccinations by the second birthday. Coverage was lower for uninsured children and for children insured by Medicaid than for those with private health insurance. Vaccination coverage can be increased by improving access to vaccine providers and eliminating missed opportunities to vaccinate children during health care visits. Increased use of local vaccination coverage data is needed to identify communities at higher risk for outbreaks of measles and other vaccine-preventable diseases.
Eradication of Vancomycin-Resistant Enterococci by Combining Phage and Vancomycin

Currently, effective options are needed to fight vancomycin-resistant Enterococcus faecalis (VRE). The present study shows that combinations of phage and vancomycin are highly efficient against VRE, despite being resistant to the antibiotic. Vancomycin-phage EFLK1 (anti-E. faecalis phage) synergy was assessed against VRE planktonic and biofilm cultures. The effect of the combined treatment on VRE biofilms was determined by evaluating the viable counts and biomass and then visualized using scanning electron microscopy (SEM). The cell wall peptidoglycan was stained after phage treatment, visualized by confocal microscopy and quantified by fluorescence activated cell sorting (FACS) analysis. The combined treatment was synergistically effective compared to treatment with phage or antibiotic alone, both in planktonic and biofilm cultures. Confocal microscopy and FACS analysis showed that fluorescence intensity of phage-treated bacteria increased eight-fold, suggesting a change in the peptidoglycan of the cell wall. Our results indicate that with combined treatment, VRE strains are not more problematic than sensitive strains and thus give hope in the continuous struggle against the current emergence of multidrug resistant pathogens.
Comparison of Time Balance Test Scores Between Aged Men and Women

Eighty two so-called healthy and able female and male persons in thier 70's and 80's without servere disabilities were examined on standing balance activities with the eyes open or closed and with both legs or one leg. Although the influence of aging between decades 70's and 80's was not prominent in female and male, the sexual difference appeared distinct in decard 70. This might-support the finding the women had more tendency to fall than men, and it should be suggested that especially elderly women need more detailed inspection to prevent fall in clinical settings.
PERCEIVED LOSS OF SOCIAL SUPPORT AFTER NON-NEUROLOGIC INJURY NEGATIVELY IMPACTS RECOVERY.

BACKGROUND Traumatic injury is not only physically devastating, but also psychologically isolating, potentially leading to poor quality of life, depression and post-traumatic stress disorder (PTSD). Perceived social support (PSS) is associated with better outcomes in some populations. What is not known is if changes in PSS influence long-term outcomes following non-neurologic injury. We hypothesized that a single drop in PSS during recovery would be associated with worse quality of life. METHODS This is a post-hoc analysis of a prospectively collected database that included patients ≥18 years old admitted to a Level 1 trauma center with injury severity score (ISS) of >10, and no traumatic brain or spinal cord injury. Demographic and injury data were collected at the initial hospital admission. Screening for depression, PTSD, and Medical Outcomes Study Short Form 36 Mental Composite Score (MCS) were obtained at the initial hospitalization, 1, 2, 4, and 12 months post-injury. The Multidimensional Scale of Perceived Social Support (MSPSS) was obtained at similar time points. Patients with high MSPSS (>5) at baseline were included and grouped by those that ever reported a score ≤ 5 (DROP), and those that remained high (STABLE). Outcomes were determined at 4 and 12 months. RESULTS 411 patients were included with 96 meeting DROP criteria at 4mo, and 97 at 1yr. There were no differences in gender, race, or injury mechanism. DROP patients were more likely to be single (p=0.012 at 4mo, p=0.0006 at 1yr) and unemployed (p=0.016 at 4mo, and p=0.026 at 1yr) compared to STABLE patients. At 4mo and 1yr, DROP patients were more likely to have PTSD, depression, and a lower MCS (p=0.0006, p<0.0001). CONCLUSION Patients who have a drop in PSS during the first year of recovery have significantly higher odds of poor psychological outcomes. Identifying these socially frail patients provides an opportunity for intervention to positively influence an otherwise poor quality of life. LEVEL OF EVIDENCE IV STUDY TYPE: Prognostic and Epidemiological.
Innate Immunity Immunomodulators in Post-Influenza Bacterial Pneumonia

Post-influenza bacterial pneumonia is a major cause of morbidity and mortality worldwide. One mechanism for enhanced susceptibility to bacterial infection after influenza is down-regulation of a major phagocytic receptor on alveolar macrophages, macrophage receptor with collagenous structure (MARCO), by interferon- (IFN-), which leads to diminished bacterial clearance. Nrf2, a transcription factor that regulates expression of antioxidant genes, is one of the regulators of MARCO expression. We show that the Nrf2 activator sulforaphane improves MARCO expression and bacterial phagocytosis in alveolar macrophage (AM)-like human monocyte-derived macrophages (HMDMs). It also improves host survival by up-regulating MARCO in a murine model of post-influenza pneumococcal pneumonia. MARCO is spontaneously restored and upregulated in the later phase of influenza virus infection. Initially, elevated IFN levels following influenza infection coincide with attenuated MARCO expression in the lungs. However, as IFN levels returned to normal levels on postinfluenza day 11, there was a striking 4.86-fold increase of MARCO expression compared to the low level observed on day 9. To identify regulatory mechanisms underlying this rebound or enhanced post-influenza MARCO expression, we performed RNA sequencing analysis of purified lung macrophages from post-influenza day 9 and 11. Among the differentially expressed genes between post-influenza day 9 and day 11 macrophages were MARCO and Akt. The Akt activator SC79 significantly increased MARCO expression on IFN-treated AM-like
Decision-based models of the implementation of interventions in systems of healthcare: Implementation outcomes and intervention effectiveness in complex service environments

Implementation is a crucial component for the success of interventions in health service systems, as failure to implement well can have detrimental impacts on the effectiveness of evidence-based practices. Therefore, evaluations conducted in real-world contexts should consider how interventions are implemented and sustained. However, the complexity of healthcare environments poses considerable challenges to the evaluation of interventions and the impact of implementation efforts on the effectiveness of evidence-based practices. In consequence, implementation and intervention effectiveness are often assessed separately in health services research, which prevents the direct investigation of the relationships of implementation components and effectiveness of the intervention. This article describes multilevel decision juncture models based on advances in implementation research and causal inference to study implementation in health service systems. The multilevel decision juncture model is a theory-driven systems approach that integrates structural causal models with frameworks for implementation. This integration enables investigation of interventions and their implementation within a single model that considers the causal links between levels of the system. Using a hypothetical youth mental health intervention inspired by published studies from the health service research and implementation literature, we demonstrate that such theory-based systems models enable investigations of the causal pathways between the implementation outcomes as well as their links to patient outcomes. Results from Monte Carlo simulations also highlight the benefits of structural causal models for covariate selection as consistent estimation requires only the inclusion of a minimal set of covariates. Such models are applicable to real-world context using different study designs, including longitudinal analyses which facilitates the investigation of sustainment of interventions.
Antipsychotic drugs v. barbiturates or benzodiazepines used as active placebos for schizophrenia: a systematic review and meta-analysis

Abstract Background Comparisons of antipsychotics with placebo can be biased by unblinding due to side effects. Therefore, this meta-analysis compared the efficacy of antipsychotics for acute schizophrenia in trials using barbiturates or benzodiazepines as active placebos. Methods Randomized controlled trials (RCTs) in acute schizophrenia with at least 3 weeks duration and comparing any antipsychotic with barbiturates or benzodiazepines were eligible. ClinicalTrials.gov, CENTRAL, EMBASE, MEDLINE, PsycINFO, PubMed, WHO-ICTRP as well as previous reviews were searched up to 9 January 2018. Two separate meta-analyses, one for barbiturates and one for benzodiazepines, were conducted using random-effects models. The primary outcome was response to treatment, and mean values of schizophrenia rating scales and dropouts were analyzed as secondary outcomes. This study is registered with PROSPERO (CRD42018086263). Results Seven barbiturate-RCTs (number of participants n = 1736), and two benzodiazepine-RCTs (n = 76) were included in the analysis. The studies were published between 1960 and 1968 and involved mainly chronically ill patients. More patients on antipsychotics in comparison to barbiturates achieved a ‘good’ response (36.2% v. 16.8%; RR 2.15; 95% CI 1.36–3.41; I2 = 48.9) and ‘any’ response (57.4% v. 27.8%; RR 2.07; 95% CI 1.35–3.18; I2 = 68.2). In a single small trial (n = 60), there was no difference between antipsychotics and benzodiazepines on ‘any’ response (74.7% v. 65%; RR 1.15; 95% CI 0.82–1.62). Conclusions Antipsychotic drugs were more efficacious than barbiturates, based on a large sample size. Response ratios were similar to those observed in placebo-controlled trials. The results on benzodiazepines were inconclusive due to the small number of studies and participants.
A Nutraceutical Rich in Docosahexaenoic Acid Improves Portal Hypertension in a Preclinical Model of Advanced Chronic Liver Disease

Inflammation and oxidative stress play a key role in the pathophysiology of advanced chronic liver disease (ACLD) and portal hypertension (PH). Considering the current lack of effective treatments, we evaluated an anti-inflammatory and antioxidant nutraceutical rich in docosahexaenoic acid (DHA) as a possible therapy for ACLD. We investigated the effects of two-week DHA supplementation (500 mg/kg) on hepatic fatty acids, PH, oxidative stress, inflammation, and hepatic stellate cell (HSC) phenotype in rats with ACLD. Additionally, the effects of DHA were evaluated in murine macrophages and human HSC. In contrast to vehicle-treated animals, cirrhotic rats receiving DHA reestablished a healthy hepatic fatty acid profile, which was associated with an improvement in PH. The mechanisms underlying this hemodynamic improvement included a reduction in oxidative stress and inflammation, as well as a marked HSC deactivation, confirmed in human HSC. Experiments with cultured macrophages showed that treatment with DHA protects against pro-inflammatory insults. The present preclinical study demonstrates that a nutraceutical rich in DHA significantly improves PH in chronic liver disease mainly by suppressing inflammation and oxidative stress-driven HSC activation, encouraging its evaluation as a new treatment for PH and cirrhosis.
Cord blood S100B: reference ranges and interest for early identification of newborns with brain injury

Abstract Background Neurological complications are common in the premature and full-term neonates admitted to the intensive care unit, but the diagnosis of these complications is often difficult to make. S100B protein, measured in cord blood, may represent a valuable tool to better identify patients at risk of brain injury. Methods As a first step, we established S100B cord blood serum reference intervals from 183 preterm and 200 full-term neonates. We then measured cord blood serum S100B to identify neurological complications in 272 neonates hospitalized at the neonatal intensive care unit (NICU). Diagnosis of brain injury relied on imaging examination. Results The 95th percentiles of S100B concentration in cord blood were established as 1.21 μg/L for the 383 neonates, 0.96 μg/L for full-term neonates and 1.36 μg/L for premature neonates. Among the 272 neonates hospitalized at the NICU, 11 presented neurological complications. Using 1.27 μg/L as the optimal sensitivity/specificity threshold, S100B differentiate neonates with and without neurological complications with a sensitivity of 45.5% (95% confidence intervals [CI]: 16.7–76.6) and a specificity of 88.9% (95% CI: 84.4–92.4) (p = 0.006). In combination with arterial pH (<7.25), sensitivity increased to 90.9% (95% CI: 58.7–99.8), while specificity was 51.2% (95% CI: 44.8–57.7). The sensitivity is significantly (p = 0.03) increased in comparison to S100B alone. The specificity is significantly higher with S100B only than with pH + S100B (p < 0.001). Conclusions Cord blood S100B protein, in combination with arterial cord blood pH, has the potential to help clinicians to detect at birth neurological complications in neonates hospitalized in an NCIU.
A panel data analysis of the utilisation of GP services in Ireland : 1995-2001

The extent to which the cost of obtaining health care influences the utilisation of GP and other health services is a frequently analysed topic. A key issue concerns the extent to which access to private health insurance and/or eligibility for free public health services results in differences in utilisation that cannot be explained by differences in need factors such as age, gender or health status. Ireland is an interesting case study in this regard as only 30 per cent of the population are eligible for free GP consultations; the remainder of the population must pay the full price. Using panel data from 1995 to 2001 on GP visits in Ireland, this paper applies a random effects approach to count data in an attempt to determine the factors influencing GP visiting patterns, with a particular focus on the role of eligibility for free public health services.
Tetratrichomonas gallinarum granuloma disease in a flock of free range layers

Abstract Granuloma disease in a flock of free range productive layers in the Netherlands in 2017 is described. The disease resembled granuloma outbreaks in layers caused by Tetratrichomonas gallinarum in 2013 and occurred in the same area in which the rearing farm considered as the source of the 2013 outbreaks was located. Between 55 and 84 weeks of age mortality was 20.3% (breeder’s norm 3.9%). All dead hens examined (n = 20) showed granulomas especially in liver and ceca. Nine hens with or without liver and/or ceca granulomas were examined for trichomonads in mentioned organs by in situ hybridization (ISH), nested PCR, and cloning and sequencing. Ceca were also examined by culture. T. gallinarum ISH was positive in all livers and ceca with granulomas and negative in case granulomas were absent. T. gallinarum strain 13/16632, which caused the 2013 outbreaks was found in 4/8 hens with granulomas. Moreover, other trichomonads were detected: a T. gallinarum strain GPO-like and a Simplicimonas sp. strain GABC1-like. Mixed infections also occurred. Infectious causes of granuloma disease other than the afore-mentioned trichomonads could be excluded. Trichomonad DNA was not detected in environmental samples and wild ducks originating from the farm of concern, except for one duck in which the same Simplicimonas sp. as in hens was detected, leaving the source of the T. gallinarum infection in hens unknown. It is concluded that the herein described granuloma disease likely was caused by T. gallinarum strain 13/16632. However, the pathogenicity of the other trichomonads found remains to be clarified.
An Ensemble Learning Approach for Electrocardiogram Sensor Based Human Emotion Recognition

Recently, researchers in the area of biosensor based human emotion recognition have used different types of machine learning models for recognizing human emotions. However, most of them still lack the ability to recognize human emotions with higher classification accuracy incorporating a limited number of bio-sensors. In the domain of machine learning, ensemble learning methods have been successfully applied to solve different types of real-world machine learning problems which require improved classification accuracies. Emphasising on that, this research suggests an ensemble learning approach for developing a machine learning model that can recognize four major human emotions namely: anger; sadness; joy; and pleasure incorporating electrocardiogram (ECG) signals. As feature extraction methods, this analysis combines four ECG signal based techniques, namely: heart rate variability; empirical mode decomposition; with-in beat analysis; and frequency spectrum analysis. The first three feature extraction methods are well-known ECG based feature extraction techniques mentioned in the literature, and the fourth technique is a novel method proposed in this study. The machine learning procedure of this investigation evaluates the performance of a set of well-known ensemble learners for emotion classification and further improves the classification results using feature selection as a prior step to ensemble model training. Compared to the best performing single biosensor based model in the literature, the developed ensemble learner has the accuracy gain of 10.77%. Furthermore, the developed model outperforms most of the multiple biosensor based emotion recognition models with a significantly higher classification accuracy gain.
Recent Progress on Near-Infrared Photoacoustic Imaging: Imaging Modality and Organic Semiconducting Agents

Over the past few decades, the photoacoustic (PA) effect has been widely investigated, opening up diverse applications, such as photoacoustic spectroscopy, estimation of chemical energies, or point-of-care detection. Notably, photoacoustic imaging (PAI) has also been developed and has recently received considerable attention in bio-related or clinical imaging fields, as it now facilitates an imaging platform in the near-infrared (NIR) region by taking advantage of the significant advancement of exogenous imaging agents. The NIR PAI platform now paves the way for high-resolution, deep-tissue imaging, which is imperative for contemporary theragnosis, a combination of precise diagnosis and well-timed therapy. This review reports the recent progress on NIR PAI modality, as well as semiconducting contrast agents, and outlines the trend in current NIR imaging and provides further direction for the prospective development of PAI systems.
Accurate and Robust Monocular SLAM with Omnidirectional Cameras

Simultaneous localization and mapping (SLAM) are fundamental elements for many emerging technologies, such as autonomous driving and augmented reality. For this paper, to get more information, we developed an improved monocular visual SLAM system by using omnidirectional cameras. Our method extends the ORB-SLAM framework with the enhanced unified camera model as a projection function, which can be applied to catadioptric systems and wide-angle fisheye cameras with 195 degrees field-of-view. The proposed system can use the full area of the images even with strong distortion. For omnidirectional cameras, a map initialization method is proposed. We analytically derive the Jacobian matrices of the reprojection errors with respect to the camera pose and 3D position of points. The proposed SLAM has been extensively tested in real-world datasets. The results show positioning error is less than 0.1% in a small indoor environment and is less than 1.5% in a large environment. The results demonstrate that our method is real-time, and increases its accuracy and robustness over the normal systems based on the pinhole model.
The association of depression and anxiety with cardiac autonomic activity: The role of confounding effects of antidepressants

Depression and anxiety may unfavorably impact on cardiac autonomic dysregulation. However, it is unclear whether this relationship results from a causal effect or may be attributable to confounding factors. We tested the relationship between depression and anxiety with heart rate (HR) and heart rate variability (HRV) across a 9‐year follow‐up (FU) period and investigated possible confounding by antidepressant use and genetic pleiotropy.
Cloning and characterization of a thermostable glutathione reductase from a psychrophilic Arctic bacterium Sphingomonas sp.

Glutathione reductase is an important oxidoreductase that helps maintain redox homeostasis by catalyzing the conversion of glutathione disulfide to glutathione using NADPH as a cofactor. In this study, we cloned and characterized a glutathione reductase (referred hereafter to as SpGR) from Sphingomonas sp. PAMC 26621, an Arctic bacterium. SpGR comprises 449 amino acids, and functions as a dimer. Surprisingly, SpGR exhibits characteristics of thermophilic enzymes, showing optimum activity at 60°C and thermal stability up to 70 °C with approximately 50% residual activity at 70 °C for 2 h. The amino acid composition analysis of SpGR showed a 1.9-fold higher Arg content (6%) and a 2.7-fold lower Lys/Arg ratio (0.75) compared to the Arg content (3.15%) and the Lys/Arg ratio (2.01) of known psychrophilic glutathione reductases. SpGR also exhibits its activity at 4°C, and circular dichroism and fluorescence spectroscopy results indicate that SpGR maintains its secondary and tertiary structures within the temperature range 4-70°C. Taken together, the results of this study indicate that despite its origin from a psychrophilic bacterium, SpGR has high thermal stability. Our study provides an insight into the role of glutathione reductase in maintaining the reducing power of an Arctic bacterium in a broad range of temperatures.