Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevention Research at the National Institutes of Health

The National Institutes of Health (NIH) is the nation’s biomedical research agency, making discoveries that improve health and save lives. Disease prevention has been an important focus of the NIH mission from the beginning. The Marine Hospital Service (MHS) was established in 1798 to screen crew members and passengers arriving in the United States to prevent epidemics of infectious diseases, such as yellow fever and cholera. The Hygienic Laboratory was established as part of the MHS in 1887 to study the etiology of these diseases and to guide prevention and treatment efforts. The MHS became the Public Health Service in 1912 with responsibility for investigating all human diseases and their contributing factors. The National Hygienic Laboratory was renamed the National Institute of Health in 1930 and was charged with ascertaining the cause, prevention, and cure of human diseases. Today, research in health promotion and disease prevention is 1 of 3 key targets in the NIH-Wide Strategic Plan to advance opportunities in biomedical research (the other targets are research in fundamental science and treatments and cures). Agencies from across the US Department of Health and Human Services (HHS), as well as academic and private-sector organizations, draw on the research supported by NIH to fulfill their missions. Each NIH institute and center defines prevention to reflect its own mission. Even so, a general working definition for prevention research at NIH is this:
Dynamic localization in optical and Zeeman lattices in the presence of spin-orbit coupling

The dynamic localization of a two-level atom in a periodic potential under the action of spin-orbit coupling and a weak harmonically varying linear force is studied. We consider optical and Zeeman potentials that are either in phase or out of phase in two spinor components, respectively. The expectation value for the position of the atom after one oscillation period of the linear force is recovered in authentic resonances or in pseudoresonances. The frequencies of the linear force corresponding to authentic resonances are determined by the band structure of the periodic potential and are affected by the spin-orbit coupling. The width or dispersion of the wave packet in authentic resonances is usually minimal. The frequencies corresponding to pseudoresonances do not depend on the type of potential and on the strength of the spin-orbit coupling, while the evolution of excitations at the corresponding frequencies is usually accompanied by significant dispersion. Pseudoresonances are determined by the initial phase of the linear force and by the quasimomentum of the wave packet. Due to the spinor nature of the system, the motion of the atom is accompanied by periodic, but not harmonic, spin oscillations. Under the action of spin-orbit coupling the oscillations of the wave packet can be nearly completely suppressed in optical lattices. Dynamic localization in Zeeman lattices is characterized by doubling of the resonant oscillation periods due to band crossing at the boundary of the Brillouin zone. We also show that higher harmonics in the Fourier expansion of the energy band lead to effective dispersion, which can be strong enough to prevent dynamic localization of the Bloch wave packet.
Concomitant activation of miR-107/PDCD10 and hypoxamir-210/Casp8ap2 and their role in cytoprotection during ischemic preconditioning of stem cells.

AIMS To establish a functional link between microRNA-107 (miR-107) and stem cell survival during ischemic preconditioning (IPC) of stem cells with multiple cycles of brief anoxia/re-oxygenation (10 or 30 min, one to three cycles) and show that the cytoprotective effects were independent of hypoxamir-210. RESULTS We demonstrated the induction of miR-107 in response to the IPC-induced activation of Akt/hypoxia inducible factor-1α (HIF-1α) in preconditioned mesenchymal stem cells ((PC)MSC), which showed improved survival during subsequent exposure to 6 h of lethal anoxia (p<0.05 vs. non-preconditioned MSC[(non-PC)MSC]). In silico analysis and luciferase activity assay confirmed programmed cell death-10 (PDCD10) as a putative target of miR-107 in (PC)MSC, which was significantly reduced during IPC and inversely related to stem cell survival under 6 h of lethal anoxia. Loss-of-function studies with miR-107 antagomir showed a significantly reduced survival of (PC)MSC. A comparison of miR-107 and miR-210 showed that both miRs participated independently via their respective putative target genes Pdcd10 and Casp8ap2. The simultaneous abrogation of Pdcd10 and Casp8ap2 had a stronger effect on (PC)MSC survival under lethal anoxia. The transplantation of (PC)MSC in an acute model of myocardial infarction showed a significantly improved survival of transplanted (PC)MSC with concomitantly enhanced miR-107 expression in (PC)MSC-transplanted animal hearts. INNOVATION Cytoprotection afforded by IPC is regulated by miR-107 induction via Pdcd10 independent of miR-210/Casp8ap2 signaling, and the simultaneous abrogation miR-107/miR-210 has a stronger effect on the loss of (PC)MSC survival. CONCLUSION IPC enhances stem cell survival via the combined participation of hypoxia responsive miRs miR-107 and miR-210 via their respective putative target genes Pdcd10 and Casp8ap2.
A New Stochastic Duration Based on the Vasicek and Cir Term Structure Theories

The stochastic duration based on the Vasicek and CIR models is theoretically superior to Macaulay's duration. However, empirical tests on bond immunization performance have so far failed to show its superiority. Within the one-factor framework, this paper proposes to use a longer zero-curve yield instead of the original instantaneous interest rate as a proxy for the relevant risk source(s). We prove that the new duration becomes larger, increasing with bond maturity, than the original duration. Bond immunization using Belgian data shows that the new duration definitely beats the original duration and can in some cases outperform Macaulay's duration. Copyright Blackwell Publishers Ltd 2000.
Oddity, schizotypy/dissociation, and personality.

The construct of Oddity was examined in relation to the dimensions of normal personality variation and a dimension of schizotypy and dissociation. In 2 studies involving samples of community adults (N = 409) and college students (N = 378), Oddity-as operationalized in terms of perceived strangeness or eccentricity-was found to be moderately related to a Schizotypy/Dissociation factor and also to factors of normal personality variation, particularly Openness to Experience. The modest loading of Oddity on the Schizotypy/Dissociation factor, along with the somewhat stronger projection of Oddity within the space of normal personality dimensions, indicates that the Schizotypy/Dissociation factor should not be interpreted as a dimension of Oddity. The interpretation of the Schizotypy/Dissociation factor is discussed, as are the implications of these results for proposed dimensional models of personality disorders.
Optimal Feedback Synthesis and Minimal Time Function for the Bioremediation of Water Resources with Two Patches

This paper studies the bioremediation, in minimal time, of a water resource or reservoir using a single continuous bioreactor. The bioreactor is connected to two pumps, at different locations in the reservoir, that pump polluted water and inject back sufficiently clean water with the same flow rate. This leads to a minimal-time optimal control problem where the control variables are related to the inflow rates of both pumps. We obtain a non-convex problem for which it is not possible to directly prove the existence of its solutions. We overcome this difficulty and fully solve the studied problem by applying Pontryagin's principle to the associated generalized control problem. We also obtain explicit bounds on its value function via Hamilton-Jacobi-Bellman techniques.
Gender differences in generalized anxiety disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC).

OBJECTIVE To assess gender differences in the epidemiology, comorbidity, and treatment-seeking patterns of DSM-IV generalized anxiety disorder (GAD) in the United States. METHOD Data were derived from the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions, a large cross-sectional survey of a representative sample (N = 43,093) of the U.S. population. RESULTS The lifetime and 12-month male:female prevalence ratios of DSM-IV GAD were 1:1.9 and 1:2.2, respectively. Men with GAD had significantly higher rates of comorbid alcohol and drug use disorders, nicotine dependence, and antisocial personality disorder. Women with GAD had significantly higher rates of comorbid mood disorders (except bipolar disorder) and anxiety disorders (except social anxiety disorder). Men with GAD reported greater use of alcohol and drugs to help relieve GAD symptoms. GAD in women was associated with higher rates of family history of depression. Disability associated with GAD was greater in women than in men. Rates of treatment seeking for DSM-IV GAD were low for both genders, but particularly low among men. CONCLUSION There are significant gender differences in the prevalence, comorbidity pattern, sociodemographic and clinical correlates, course, and treatment-seeking rates of persons with DSM-IV GAD. Increased recognition and treatment of GAD, particularly among men, could lead to substantial reductions in the societal and personal burden and improve the quality of life of those afflicted with this disorder.
Reduced-Order Model and Control Approach for the Boost Converter With a Voltage Multiplier Cell

The boost converter with a voltage multiplier cell allows the static gain extension by means of the switching capacitor technique, reducing the duty cycle needed to achieve the same voltage gain when compared to the conventional boost converter. However, the modeling of this converter is complex and requires the use of advanced techniques due to the resonant inductor. Thus, this paper aims to present a reduced-order model of this converter without the resonant energy exchange between the capacitors, so that the state-space averaging technique can be applied assuming small ripple in the state variables. In addition, this paper presents the design of a control system for the boost converter with a voltage multiplier cell. The adopted strategy employs an inner loop to control the input current and an outer loop for the output voltage regulation. Extensive analysis based on simulations and an experimental prototype demonstrate that the proposed modeling, although simplified, is sufficient for an adequate control system design, ensuring good voltage regulation, and fast transient responses.
A Boundary Element Formulation for the Pricing of Barrier Options

In this article, we derive a boundary element formulation for the pricing of barrier option. The price of a barrier option is modeled as the solution of Black-Scholes’ equation. Then the problem is transformed to a boundary value problem of heat equation with a moving boundary. The boundary integral representation and integral equation are derived. A boundary element method is designed to solve the integral equation. Special quadrature rules for the singular integral are used. A numerical example is also demonstrated. This boundary element formulation is correct.
Research on the Building Information Model of the stone building for heritages conservation With the outer south gate of the Ta Keo Temple as an example

This article mainly discussed the principle and method to create the Building Information Model (BIM) for a stone architectural heritage. As a typical case for stone heritages, the BIM of the outer south gate in the Ta Keo Temple in Cambodia was built according to requirements on heritage protection and management. In the case, we studied three important problems about the stone BIM: the mode of the BIM, the sorts of the families and the contents of component attributes. By literature study, on-the-spot investigation, data analysis and repeating tests, we not only set a dynamic BIM for the gate, but also summarized primarily the basic techniques and scientific flow to build the BIM for a stone heritage.
Phaseless Synthetic Aperture Radar With Efficient Sampling for Broadband Near-Field Imaging: Theory and Validation

This paper presents a broadband and phaseless synthetic aperture radar (SAR) with efficient sampling. The design relies on a novel phaseless monostatic element comprising a transmitter and a receiver. This element, together with a computationally inexpensive algorithm, can retrieve the phase of the monostatic scattered field at all the working band except for two small safety margins at the lower and upper frequencies. Furthermore, the phase retrieval works independently of the transmitter/receiver position. Consequently, conventional approaches to reduce the number of monostatic acquisition points can be employed. Thus, the proposed strategy is suitable to implement either arrays that benefit from a reduced number of low-complexity elements or raster scan systems that benefit not only from the cost reduction of the scanning components but also from a remarkable speed-up due to the reduced number of acquisition points. Moreover, in contrast to other off-axis schemes, the proposed system does not require neither mechanical nor electrical phase shifting and, therefore, it can be directly adapted to a large number of frequency bands. The performance of the system is validated by simulation and measurement examples in the millimeter-wave band.
Phylloplane fungi in Hong Kong mangroves: evaluation of study methods

Many methods have been used to study phylloplane fungi, most of which have constraints and may result in biased results. This study used light microscopy and scanning electron microscopy (SEM) to investigate fungal abundance on the leaves of the most common mangrove trees in Hong Kong, Kandelia candel and Aegiceras corniculatum. Species richness was investigated using light microscopy and a leaf washing method. Methods to study phylloplane fungi are discussed and the performances of these three investigation methods are evaluated. Seven mitosporic fungal taxa were found by light microscopy, while 30 sporulating taxa and 18 Mycelia sterilia were isolated using the leaf washing method. Fungal abundance in terms of percentage cover investigated with light microscopy was similar using the SEM method, and was significantly higher on Aegiceras corniculatum than on Kandelia candel. Fungal abundance peaked in the summer and was lowest in the winter. This study indicates that light microscopy reveals the most typical phylloplane fungi and is more efficient than SEM, while the leaf washing method reveals many casual species and is not quantitative.
Fractional Ca2+ currents through somatic and dendritic glutamate receptor channels of rat hippocampal CA1 pyramidal neurones.

1. The Ca2+ permeability of non‐NMDA and NMDA receptor channels was studied using a fluorometric flux measurement approach in somata and dendrites of CA1 pyramidal neurones in rat hippocampal slices. For this purpose, the Ca2+ fraction of the total cation current (named ‘fractional Ca2+ current') was measured directly from the change in the Ca(2+)‐sensitive fura‐2 fluorescence at 380 nm excitation wavelength. 2. The fractional Ca2+ current through the somatic NMDA receptor channels was 10.69 +/‐ 2.13% (mean +/‐ S.D.) and that through dendritic receptor channels was 10.70 +/‐ 1.96%. The fractional Ca2+ current was not dependent on the extracellular Mg2+ concentration and its voltage dependence was in agreement with the Goldman‐Hodgkin‐Katz current equation. 3. AMPA (alpha‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate) or kainate applications produced small but significant Ca2+ entry. Fractional Ca2+ currents of 0.58 +/‐ 0.34% were measured for somatic AMPA applications, 0.68 +/‐ 0.20% for somatic kainate applications, 0.66 +/‐ 0.25% for dendritic AMPA applications and 0.61 +/‐ 0.16% for dendritic kainate applications. 4. The expression pattern of glutamate receptor subunits encoding messenger ribonucleic acids (mRNAs) was analysed with the single‐cell reverse transcriptase‐polymerase chain reaction (RT‐PCR) approach applied to CA1 pyramidal neurones. The AMPA receptor subunits GluR‐A, GluR‐B and GluR‐C, and the NMDA receptor subunits NR2A and NR2B were found to be abundantly expressed in all CA1 pyramidal neurones tested. 5. This study establishes the fractional Ca2+ current through somatic and dendritic NMDA and non‐NMDA receptor channels in CA1 pyramidal neurones. The dendritic, presumably synaptic, NMDA receptor channels are highly Ca2+ permeable and have a fractional Ca2+ current closely resembling that of somatic extrasynaptic NMDA receptor channels. Both somatic and dendritic non‐NMDA receptor channels are of the ‘low Ca2+ permeable’ type and have a fractional Ca2+ current that is about twenty times smaller than that of NMDA receptor channels.
Intelligence and the Frontal Lobe: The Organization of Goal-Directed Behavior

Basic to the study of individual differences is the concept of 'general intelligence' or Spearman's g. In this article we suggest that g is largely a reflection of the control functions of the frontal lobe. A series of experiments investigates a phenomenon we call goal neglect: disregard of a task requirement event though it has been understood and remembered. Subjectively it is as though the neglected requirement "slips the subject's mind. " Previously described in frontal patients, we show that goal neglect can also be seen in some members of the normal population. In line with conventional distinctions between controlled and automatic processing, eliciting conditions for goal neglect include novelty, weak error feedback, and multiple concurrent task requirements. Under these conditions neglect is linked closely to g and extremely common after frontal lesions. Following many other models, we suggest that behavior in any task is structured by a set of action constraints or requirements, derived in part from verbal instructions and specified at multiple levels of abstraction. A frontal process of constraint or requirement activation is fundamental to Spearman's g.
The Secure Shell (SSH) Protocol Architecture

The Secure Shell (SSH) Protocol is a protocol for secure remote login and other secure network services over an insecure network. This document describes the architecture of the SSH protocol, as well as the notation and terminology used in SSH protocol documents. It also discusses the SSH algorithm naming system that allows local extensions. The SSH protocol consists of three major components: The Transport Layer Protocol provides server authentication, confidentiality, and integrity with perfect forward secrecy. The User Authentication Protocol authenticates the client to the server. The Connection Protocol multiplexes the encrypted tunnel into several logical channels. Details of these protocols are described in separate documents. [STANDARDS-TRACK]
Advanced Electromagnetic Analysis for Electron Source Geometries

One of the challenging issues for analytically modeling electron sources, such as rf photoinjectors, is calculating time-dependent electromagnetic fields generated by the electron beam within a complicated conductor boundary. This problem can be handled self-consistently using a time-dependent Green’s function method. We demonstrate this approach for a simplified electron source geometry, namely a semi-infinite circular pipe with a cathode. Following similar Lorentz gauge approaches that were used for computing electromagnetic potentials in low frequency (< 1 GHz) photoinjectors [1,2], we present a compact Green’s function solution for this simplified geometry. As an application, we show the electromagnetic potentials for a disk bunch of charge emanating from the cathode wall with acceleration parameters corresponding to the BNL 2.856 GHz 1.6 cell photocathode gun. [3]
The effect of early postnatal treatment with a gonadotropin-releasing hormone agonist on the developmental profiles of testicular steroid hormones in the intact male pig.

Three studies examined the effects of early postnatal treatment with a GnRH agonist on plasma concentrations of testosterone, dehydroepian-drosterone sulfate, 16-androstene steroids in fat and salivary glands, androstenone in fat and plasma, and testicular development of intact male pigs. The first study involved 45 7-d-old pigs assigned to three treatment groups: 1) boars administered 100 microg/kg of Lupron depot, 2) boars administered 200 microg/kg of Lupron depot, and 3) control boars receiving a saline carrier. The second study involved 20 7-d-old pigs assigned to two treatments: daily injection of 200 microL of 0.5 mg/mL Lupron from d 7 to 35 and controls treated with saline. The third study involved a total of 100 animals assigned to 10 groups of 10 based on their age at slaughter. These groups were subdivided into one of two treatments: 1) boars injected with 200 microL of 0.5 mg/mL of Lupron from d 3 to 35 and 2) control boars injected with saline. Testicular steroid hormone concentrations in plasma decreased (P < 0.01) within 7 d of GnRH agonist treatment. Following cessation of treatment, steroid levels increased to control levels and remained constant until the final rise at 5 mo. Plasma testosterone levels in the 100 microg/kg depot treatment group were higher (P < 0.05) than that of the 200 microg/kg and control group at 164 d of age. There were no differences between treatments (P > 0.05) in testicular steroid hormone levels at the end of study 2 or 3. There were no differences (P > 0.05) in concentrations of 16-androstene steroids in salivary glands between any of the treatment groups at market weight in studies 1 and 2. Fat androstenone levels measured in the third study ranged between 0.6 microg/g and 4.2 microg/g at 7 to 28 d of age. Treatment with GnRH agonist decreased plasma steroid levels and testicular development; however, by d 60 testicular size and weight were at control levels and remained similar until 180 d of age. The results of these studies indicate that daily administration of a GnRH agonist significantly decreased testicular development and steroidogenesis only during treatment, but testis growth and steroidogenesis had returned to control levels by 60 d of age in male pigs. Suppression of the early postnatal rise in testicular steroid hormones did not affect growth performance or steroid hormone levels at 5 to 6 mo of age.
Inter-Rater Reliability of Neck Reflex Points in Women with Chronic Neck Pain

Background: Neck reflex points (NRP) are tender soft tissue areas of the cervical region that display reflectory changes in response to chronic inflammations of correlated regions in the visceral cranium. Six bilateral areas, NRP C0, C1, C2, C3, C4 and C7, are detectable by palpating the lateral neck. We investigated the inter-rater reliability of NRP to assess their potential clinical relevance. Methods: 32 consecutive patients with chronic neck pain were examined for NRP tenderness by an experienced physician and an inexperienced medical student in a blinded design. A detailed description of the palpation technique is included in this section. Absence of pain was defined as pain index (PI) = 0, slight tenderness = 1, and marked pain = 2. Findings were evaluated either by pair-wise Cohen's kappa (ĸ) or by percentage of agreement (PA). Results: Examiners identified 40% and 41% of positive NRP, respectively (PI > 0, physician: 155, student: 157) with a slight preference for the left side (1.2:1). The number of patients identified with >6 positive NRP by the examiners was similar (13 vs. 12 patients). ĸ values ranged from 0.52 to 0.95. The overall kappa was ĸ = 0.80 for the left and ĸ = 0.74 for the right side. PA varied from 78.1% to 96.9% with strongest agreement at NRP C0, NRP C2, and NRP C7. Inter-rater agreement was independent of patients' age, gender, body mass index and examiner's experience. Conclusion: The high reproducibility suggests the clinical relevance of NRP in women.