Miracle-dz/UniFAR-FTUs huggingface dataset:
Wearable inertial sensors for objective kinematic assessments: A brief overview

Approximately 1.71 billion people were affected by debilitating musculoskeletal disorders (MSDs) in 2019 (WHO 2021). The personal and societal burdens of MSDs are well-documented and considerable, and immediate action is needed to address their underlying risk factors (Briggs et al. 2018, 2020; Cieza et al. 2020; Wu et al. 2020). Occupational exposure to kinematic risk factors such as non-neutral postures and high movement speeds have been associated with the development of MSDs (NRC-IOM 2001; Punnett and Wegman 2004; Driscoll et al. 2014; van der Molen et al. 2017; Balogh et al. 2019). Accurately measuring worker kinematics and reducing exposure to harmful movements through intervention is one of several potential paths to preventing MSDs (Buckle and Devereux 2002; Mathiassen et al. 2015; Howard et al. 2022). Accelerometers (a.k.a. inclinometers) emerged in the 1980s and 1990s as a preferred method for objectively quantifying some worker kinematics and estimating energy expenditure in epidemiological research (Bussmann et al. 1995; Li and Buckle 1999; Bassett 2000; Janz 2006). Measurements from accelerometers may be combined with angular velocity measurements from gyroscopes and local magnetic field information from a magnetometer to provide more accurate kinematic assessments than accelerometers alone (Luinge and Veltink 2005; Madgwick 2010). This complementary arrangement of sensors in a single device is generally known as an inertial measurement unit (IMU). The use of IMUs in ergonomics has increased substantially in recent years, particularly among researchers (Lim and D’Souza 2020). Applications range from characterizing non-neutral postures such as extreme shoulder elevation or trunk flexion and associated movement speeds (Fethke et al. 2020; Schall et al. 2021) to classifying types of materials handling tasks (Hosseinian et al. 2019; Porta et al. 2021) to monitoring the development of fatigue based on gait kinematics and smoothness of motion (jerk) (Zhang et al. 2014; Maman et al. 2017; Baghdadi et al. 2021; Hostler et al. 2021). Readers are directed to three recent reviews that detail the applications of IMUs for ergonomic assessment (Ranavolo et al. 2018; Lim and D’Souza 2020; Stefana et al. 2021). Occupational safety and health professionals have reported interest in using wearable IMUs to assess and monitor kinematic risk factors at work (Schall et al. 2018). Several companies sell systems of IMU sensors with proprietary software to facilitate "plugand-play" kinematic assessment (e.g., Xsens MTw Awinda (Paulich et al. 2018); APDM Opal (Horak et al. 2011)). IMUs have also been shown to perform accurately when operated independently with opensource resources (Chen et al. 2020; Nazarahari and Rouhani 2021). Despite their potential value to organizations and the expanding body of studies supporting their efficacy, occupational safety and health professionals have reported concerns that the data provided by IMUs may be perceived as insufficiently accurate for use in their workplaces (Reid et al. 2017; Schall et al.
Inflammatory linear verrucous epidermal nevus (ILVEN) encompasses a spectrum of inflammatory mosaic disorders

Inflammatory linear verrucous epidermal nevus (ILVEN) is a rare skin disease characterized by pruritic erythematous scaly plaques distributed along the lines of Blaschko. Two cases of ILVEN with CARD14 mutations and one case with a GJA1 mutation have been previously reported.
G‐CSF Receptor Deletion Amplifies Cortical Bone Dysfunction in Mice With STAT3 Hyperactivation in Osteocytes

Bone strength is determined by the structure and composition of its thickened outer shell (cortical bone), yet the mechanisms controlling cortical consolidation are poorly understood. Cortical bone maturation depends on SOCS3‐mediated suppression of IL‐6 cytokine‐induced STAT3 phosphorylation in osteocytes, the cellular network embedded in bone matrix. Because SOCS3 also suppresses granulocyte‐colony‐stimulating factor receptor (G‐CSFR) signaling, we here tested whether global G‐CSFR (Csf3r) ablation altereed bone structure in male and female mice lacking SOCS3 in osteocytes, (Dmp1Cre:Socs3f/f mice). Dmp1Cre:Socs3f/f:Csf3r−/− mice were generated by crossing Dmp1Cre:Socs3f/f mice with Csf3r−/− mice. Although G‐CSFR is not expressed in osteocytes, Csf3r deletion further delayed cortical consolidation in Dmp1Cre:Socs3f/f mice. Micro‐CT images revealed extensive, highly porous low‐density bone, with little true cortex in the diaphysis, even at 26 weeks of age; including more low‐density bone and less high‐density bone in Dmp1Cre:Socs3f/f:Csf3r−/− mice than controls. By histology, the area where cortical bone would normally be found contained immature compressed trabecular bone in Dmp1Cre:Socs3f/f:Csf3r−/− mice and greater than normal levels of intracortical osteoclasts, extensive new woven bone formation, and the presence of more intracortical blood vessels than the already high levels observed in Dmp1Cre:Socs3f/f controls. qRT‐PCR of cortical bone from Dmp1Cre:Socs3f/f:Csf3r−/− mice also showed more than a doubling of mRNA levels for osteoclasts, osteoblasts, RANKL, and angiogenesis markers. The further delay in cortical bone maturation was associated with significantly more phospho‐STAT1 and phospho‐STAT3‐positive osteocytes, and a threefold increase in STAT1 and STAT3 target gene mRNA levels, suggesting G‐CSFR deletion further increases STAT signaling beyond that of Dmp1Cre:Socs3f/f bone. G‐CSFR deficiency therefore promotes STAT1/3 signaling in osteocytes, and when SOCS3 negative feedback is absent, elevated local angiogenesis, bone resorption, and bone formation delays cortical bone consolidation. This points to a critical role of G‐CSF in replacing condensed trabecular bone with lamellar bone during cortical bone formation. © 2022 American Society for Bone and Mineral Research (ASBMR).
Feasibility of triple gamma ray imaging of 10C for range verification in ion therapy

Objective. In carbon ion therapy, the visualization of the range of incident particles in a patient body is important for treatment verification. In-beam positron emission tomography (PET) imaging is one of the methods to verify the treatment in ion therapy due to the high quality of PET images. We have shown the feasibility of in-beam PET imaging of radioactive 15O and 11C ion beams for range verification using our OpenPET system. Recently, we developed a whole gamma imager (WGI) that can simultaneously work as PET, single gamma ray and triple gamma ray imaging. The WGI has high potential to detect the location of 10C, which emits positrons with a simultaneous gamma ray of 718 keV, within the patient’s body during ion therapy. Approach. In this work, we focus on investigating the performance of WGI for 10C imaging and its feasibility for range verification in carbon ion therapy. First, the performance of the WGI was studied to image a 10C point source using the Geant4 toolkit. Then, the feasibility of WGI was investigated for an irradiated polymethyl methacrylate (PMMA) phantom with a 10C ion beam at the carbon therapy facility of the Heavy Ion Medical Accelerator in Chiba. Main results. The average spatial resolution and sensitivity for the simulated 10C point source at the centre of the field of view were 5.5 mm FWHM and 0.010%, respectively. The depth dose of the 10C ion beam was measured, and the triple gamma image of 10C nuclides for an irradiated PMMA phantom was obtained by applying a simple back projection to the detected triple gammas. Significance. The shift between Bragg peak position and position of the peak of the triple gamma image in an irradiated PMMA phantom was 2.8 ± 0.8 mm, which demonstrates the capability of triple gamma imaging using WGI for range verification of 10C ion beams.
A Combined Cycle Gas Turbine Model for Heat and Power Dispatch Subject to Grid Constraints

This paper investigates an optimal scheduling method for the operation of combined cycle gas turbines (CCGT). The objective is to minimize the CO2 emissions while supplying both electrical and thermal loads. This paper adopts a detailed model of the units in order to relate the heat and power outputs. The grid constraints as well as system losses are considered for both the electrical and thermal systems. Finally, the optimal power dispatch lies on the hybridization of a mixed integer linear programing scheduling with a greedy search method. Different sets of simulations are run for a small 5-bus test case and a larger model of Jurong Island in Singapore. Several load levels are considered for the heat demand, and the impact of the steam pipe capacities is highlighted.
A New Graph Autoencoder-Based Consensus-Guided Model for scRNA-seq Cell Type Detection

Single-cell RNA sequencing (scRNA-seq) technology is famous for providing a microscopic view to help capture cellular heterogeneity. This characteristic has advanced the field of genomics by enabling the delicate differentiation of cell types. However, the properties of single-cell datasets, such as high dropout events, noise, and high dimensionality, are still a research challenge in the single-cell field. To utilize single-cell data more efficiently and to better explore the heterogeneity among cells, a new graph autoencoder (GAE)-based consensus-guided model (scGAC) is proposed in this article. The data are preprocessed into multiple top-level feature datasets. Then, feature learning is performed by using GAEs to generate new feature matrices, followed by similarity learning based on distance fusion methods. The learned similarity matrices are fed back to the GAEs to guide their feature learning process. Finally, the abovementioned steps are iterated continuously to integrate the final consistent similarity matrix and perform other related downstream analyses. The scGAC model can accurately identify critical features and effectively preserve the internal structure of the data. This can further improve the accuracy of cell type identification.
Perceived Benefits of Ethics Consultation Differ by Profession: A Qualitative Survey Study

Abstract Background: There are numerous benefits to ethics consultation services, but little is known about the reasons different professionals may or may not request an ethics consultation. Inter-professional differences in the perceived utility of ethics consultation have not previously been studied. Methods: To understand profession-specific perceived benefits of ethics consultation, we surveyed all employees at an urban tertiary children’s hospital about their use of ethics committee services (n = 842). Results: Our findings suggest that nurses and physicians find ethics consultations useful for different reasons; physicians were more likely to report normative benefits, while nurses were more likely to report communicative and relational benefits. Conclusions: These findings support an open model of ethics consultation and may also help ethics committees to better understand consultation requests and remain attuned to the needs of various professional groups.
Real power loss diminution by camelopard optimization algorithm

In this work Camelopard optimization Algorithm (COA) has been formulated &utilized for solving the optimal reactive power problem. Activities of Camelopard & itsSocial hierarchies are imitated to formulate this algorithm. Normally males use necking, and as a weapon in assaut portion. Among mammals, the tallest living terrestrial animal and it possess the largest ruminants. It has special approach to explore the grass land in quick mode& this aspect has been utilized in the formulation of the algorithm. Efficiency of the projected Camelopard optimization Algorithm (COA) is validated by evaluating in standard IEEE 30, 57, 118, 300 bus test systems. Also by considering the voltage stability evaluation the proposed algorithm has been tested in standard IEEE 30 bus system simulated outcomes shows that genuine power loss has been reduced considerably with variables are in the limits. RÉSUMÉ. Dans ce travail, l'algorithme d'optimisation Camelopard (COA) a été formulé et utilisé pour résoudre le problème optimal de la puissance réactive. Les activités de Camelopard et de ses hiérarchies sociales sont imitées pour formuler cet algorithme. Normalement, les mâles utilisent le strictard comme arme dans les assauts. Parmi les mammifères, l'animal terrestre vivant le plus haut et celui qui possède les plus grands ruminants. Il a une approche spéciale pour explorer la pelouse en mode rapide et cet aspect a été utilisé dans la formulation de l'algorithme. L’efficacité de l’algorithme d’optimisation Camelopard (COA) projeté est validée par l’évaluation des systèmes de test de bus IEEE 30, 57, 118, 300. En considérant également l’évaluation de la stabilité de la tension, l’algorithme proposé a été testé dans une simulation de système de bus IEEE 30 standard. Les résultats simulés montrent que la perte de puissance réelle a été considérablement réduite avec des variables situées dans les limites.
Carbon dots with intrinsic theranostic properties for photodynamic therapy of oral squamous cell carcinoma

Carbon dots (CDs) are one of the carbon-based materials with remarkable optical properties, good water dispersibility and high biocompatibility. However, few studies have emphasized the intrinsic photodynamic and anticancer properties of CDs. Herein, we used CDs as photosensitizers to explore their photodynamic therapy (PDT) effect on oral squamous cell carcinoma (OSCC) cells. The obtained CDs had an effective cellular internalization capacity and possessed good biocompatibility in both CAL-27 and UM1 cells. After irradiation, the CDs showed obvious photodynamic effects on the test cells, which were confirmed by apoptosis analysis. In addition, the CDs exhibited excellent intracellular ROS generation under irradiation, and the subsequent induced cell death may be related to a lysosome-associated pathway.
Diabetes self-management: a qualitative study on challenges and solutions from the perspective of South African patients and health care providers

ABSTRACT Background Health education and self-management are among key strategies for managing diabetes and hypertension to reduce morbidity and mortality. Inappropriate self-management support can potentially worsen chronic diseases outcomes if relevant barriers are not identified and self-management solutions are not contextualised. Few studies deliberately solicit suggestions for enhancing self-management from patients and their providers. Objective This qualitative study aimed to unravel experiences, identify self-management barriers, and solicit solutions for enhancing self-management from patients and their healthcare providers. Methods Eight in-depth interviews were conducted with healthcare providers. These were followed by four focus group discussions among patients with type-2- diabetes and or hypertension receiving chronic disease care from two health facilities in a peri-urban township in Cape Town, South Africa. The Self-Management framework described by Lorig and Holman, based on work done by Corbin and Strauss was used to analyse the data. Results Patients experienced challenges across all three self-management tasks of behavioural/medical management, role management, and emotional management. Main challenges included poor patient self-control towards lifestyle modification, sub-optimal patient-provider and family partnerships, and post-diagnosis grief-reactions by patients. Barriers experienced were stigma, socio-economic and cultural influences, provider-patient communication gaps, disconnect between facility-based services and patients’ lived experiences, and inadequate community care services. Patients suggested empowering community-based solutions to strengthen their disease self-management, including dedicated multidisciplinary diabetes services, counselling services; strengthened family support; patient buddies; patient-led community projects, and advocacy. Providers suggested contextualised communication using audio-visual technologies and patient-centred provider consultations. Conclusions Community-based dedicated multidisciplinary chronic disease healthcare teams, chronic disease counselling services, patient-driven projects and advocacy are needed to improve patient self-management.
Enhancing GAT-3 in thalamic astrocytes promotes resilience to brain injury in rodents

Inflammatory processes induced by brain injury are important for recovery; however, when uncontrolled, inflammation can be deleterious, likely explaining why most anti-inflammatory treatments have failed to improve neurological outcomes after brain injury in clinical trials. In the thalamus, chronic activation of glial cells, a proxy of inflammation, has been suggested as an indicator of increased seizure risk and cognitive deficits that develop after cortical injury. Furthermore, lesions in the thalamus, more than other brain regions, have been reported in patients with viral infections associated with neurological deficits, such as SARS-CoV-2. However, the extent to which thalamic inflammation is a driver or by-product of neurological deficits remains unknown. Here, we found that thalamic inflammation in mice was sufficient to phenocopy the cellular and circuit hyperexcitability, enhanced seizure risk, and disruptions in cortical rhythms that develop after cortical injury. In our model, down-regulation of the GABA transporter GAT-3 in thalamic astrocytes mediated this neurological dysfunction. In addition, GAT-3 was decreased in regions of thalamic reactive astrocytes in mouse models of cortical injury. Enhancing GAT-3 in thalamic astrocytes prevented seizure risk, restored cortical states, and was protective against severe chemoconvulsant-induced seizures and mortality in a mouse model of traumatic brain injury, emphasizing the potential of therapeutically targeting this pathway. Together, our results identified a potential therapeutic target for reducing negative outcomes after brain injury. Description Thalamic inflammation mediates enhanced seizure risk and altered cognition–related cortical states through astrocytic GAT-3 in mice. Halting astrocytes at the GAT3 Uncontrolled inflammation in the brain after an injury has been shown to contribute to increased seizure risk and cognitive impairments. The thalamus is a brain area particularly susceptible to damage after an injury. Here, Cho and colleagues showed that thalamic inflammation per se was sufficient to trigger the negative effects of brain injury by modulating the expression of the GABA-transported GAT3 in astrocytes. Restoring the expression of the GABA-transported GAT3 in this cell population reduced the negative outcomes associated with brain injury, suggesting that targeting astrocytes in the thalamus might be effective for preventing negative outcomes after brain injury.
Extrahippocampal Seizure and Memory Circuits Overlap

Abstract Seizures cause retrograde amnesia. We have previously demonstrated that seizures erode recently formed memories through shared ensembles and mechanisms in the CA1 region of the hippocampus. Here, we tested whether seizure circuits overlap spatial memory circuits outside of the CA. Spatial memory is consolidated by the hippocampal-cortical coupling that are connected via multiple pathways. We tested whether a seizure invades structures involved in memory consolidation by using the activity reporter TRAP2 mice. T-maze alternation learning activated neurons in the dentate gyrus (DG), mediodorsal thalamus (MD), retrosplenial cortex (RSC), and medial prefrontal cortex (mPFC). This spatial memory relies on the plasticity of the AMPA receptor GluA1 subunit. GluA1 knock-out (KO)/TRAP2 mice did not learn to alternate, and structures interposed between the hippocampus and the cortex were not active. A seizure prevented the recall of alternation memory and activated memory-labeled structures. There was a widespread overlap between learning-activated ensembles and seizure-activated neurons, which likely contributes to retrograde amnesia.
Peer-to-Peer Packet Dispatching for Multi-Router Local Area Packetized Power Networks

With a large penetration of distributed energy resources, DC power packet transmission has emerged as a promising technique to achieve efficient peer-to-peer (P2P) power dispatching. In this paper, a multirouter local area packetized power network (LAPPN) is considered, consisting of multiple power routers employed to dispatch power packets among demander and supplier subscribers connected to different routers. To realize the efficient P2P power transmission in the LAPPN, a power packet dispatching protocol is developed to determine the optimal routes for power packets to maximize the power packets utilization efficiency. The transmission schedule is then determined by allocating different power packets on different power channels simultaneously to accommodate the urgency requirements of different demander energy subscribers (ESs). Simulation results demonstrate the effectiveness of the proposed LAPPN power dispatching protocols in achieving high power packet utilization and meeting the urgency requirements of different demander ESs in P2P power delivery.
History of pre‐pregnancy maternal symptoms of binge eating and childhood behavioral problems in girls and boys

Abstract Objective To explore whether children of mothers with pre‐pregnancy binge eating (BE) symptoms have more behavioral difficulties compared with those without and whether associations are moderated by ED symptoms and other maternal health and social factors measured during childhood. Method Pre‐pregnancy BE symptoms were collected by the Australian Longitudinal Study on Women's Health at Survey 1 (in 1996) and/or at Survey 2 (in 2000) using questions mapped to DSM BE criterion 1. In 2016/7, 2180 women from the 1973–78 cohort provided data on externalizing and internalizing behavior, measured by Strengths and Difficulties Questionnaire, on 4054 of their children (2–12 years) in the Mothers and their Children's Health study. Covariates were markers of other ED symptoms, sociodemographic, social support, and mental health factors collected proximally to the child outcomes. Hierarchical multivariable regression models, using generalized estimating equations accounting for clustering of children within mothers, were used. Results Pre‐pregnancy BE symptoms were associated with child behavior, with associations only moderated after adjustment for proximal markers of ED (girls internalizing behavior, b (95%CI) . 30 (−.02, .61); boys externalizing behavior . 34 (−.04, .73)) or social support (girls externalizing behavior 0.26 (−.08, .61)). Pre‐pregnancy BE symptoms were not associated with boys internalizing behavior (−.27 (−.02, 0.57)). Discussion Studies with repeated ED measures should test hypotheses that these associations vary by timing of ED measurement. Identification of young women at risk of BE symptoms pre‐pregnancy, as well as when children are older, may enable health services, treatment programs, and supports to minimize longer term effects on children. Public significance statement A history of binge eating symptoms up to 10 years pre‐pregnancy in mothers is associated with behavior problems in their girls and boys at average age of 7. However, the association is moderated by behaviors of eating disorders and social support in the mothers during childhood. Identification of ED symptoms prior to pregnancy, and then after childbirth, might enable health services to intervene to maximize child and mother outcomes.
Coparenting‐focused preventive intervention reduces postnatal maternal BMI and buffers impact of cortisol

The postpartum period is a key life stage, contributing to increased maternal obesity risk. Current lifestyle interventions do not consider the role of a woman's partner in reducing stress and supporting lifestyle change. The objective of this study was to assess the effect of an intervention that seeks to enhance coparenting relationship quality on maternal BMI from before conception to 12 months post partum and whether the intervention moderated the association of changes in cortisol and BMI.