Miracle-dz/UniFAR-FTUs huggingface dataset:
Esophageal Doppler Can Predict Fluid Responsiveness Through End-Expiratory and End-Inspiratory Occlusion Tests

Objectives: To assess whether, in patients under mechanical ventilation, fluid responsiveness is predicted by the effects of short respiratory holds on cardiac index estimated by esophageal Doppler. Design: Prospective, monocentric study. Setting: Medical ICU. Patients: Twenty-eight adult patients with acute circulatory failure and a decision of the clinicians in charge to administer fluids. Interventions: Before and after infusing 500 mL of saline, we measured cardiac index estimated by esophageal Doppler before and during the last 5 seconds of successive 15-second end-inspiratory occlusion and end-expiratory occlusion, separated by 1 minute. Patients in whom volume expansion increased cardiac index measured by transpulmonary thermodilution greater than or equal to 15% were defined as “fluid responders. ” Cardiac index measured by the Pulse Contour Cardiac Output device (from pulse contour analysis or transpulmonary thermodilution) was used as the reference. Measurements and Main Results: End-expiratory occlusion increased cardiac index estimated by esophageal Doppler more in responders than in nonresponders (8% ± 2% vs 3% ± 1%, respectively; p < 0.0001) and end-inspiratory occlusion decreased cardiac index estimated by esophageal Doppler more in responders than in nonresponders (–8% ± 5% vs –4% ± 2%, respectively; p = 0.0002). Fluid responsiveness was predicted by the end-expiratory occlusion induced percent change in cardiac index estimated by esophageal Doppler with an area under the receiver operating characteristic curve of 1.00 (95% CI, 0.88–1.00) and a threshold value of 4% increase in cardiac index estimated by esophageal Doppler. It was predicted by the sum of absolute values of percent changes in cardiac index estimated by esophageal Doppler during both occlusions with a similar area under the receiver operating characteristic curve (0.99 [0.86–1.00]) and with a threshold of 9% change in cardiac index estimated by esophageal Doppler, which is compatible with the esophageal Doppler precision. Conclusions: If the absolute sum of the percent change in cardiac index estimated by esophageal Doppler induced by two successive end-inspiratory occlusion and end-expiratory occlusion maneuvers is greater than 9%, it is likely that a 500 mL fluid infusion will increase cardiac output. This diagnostic threshold is higher than if only end-expiratory occlusion induced percent changes in cardiac index estimated by esophageal Doppler are taken into account.
A 0.8μm CMOS Programmable Analog-Array-Processing Vision-Chip with Local Logic and Image-Memory

An operational vision-chip prototype with a wide-range of potential applications in artificial-vision systems is presented. Its functionality includes concurrent image-transduction, programmable image-processing, image-storage, and algorithmic control over a network of 20 × 22 identical cells. The prototype has been designed and manufactured in 0. 8μm CMOS standard technology, and has a total area of 30mm2. Experimental results are reported.
Accurate Extraction of the Self-Rotational Speed for Cells in an Electrokinetics Force Field by an Image Matching Algorithm

We present an image-matching-based automated algorithm capable of accurately determining the self-rotational speed of cancer cells in an optically-induced electrokinetics-based microfluidic chip. To automatically track a specific cell in a video featuring more than one cell, a background subtraction technique was used. To determine the rotational speeds of cells, a reference frame was automatically selected and curve fitting was performed to improve the stability and accuracy. Results show that the algorithm was able to accurately calculate the self-rotational speeds of cells up to ~150 rpm. In addition, the algorithm could be used to determine the motion trajectories of the cells. Potential applications for the developed algorithm include the differentiation of cell morphology and characterization of cell electrical properties.
Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer

Breast cancer (BC) is the most common type of cancer in women worldwide; it is a multifactorial genetic disease. Acetylation and deacetylation are major post-translational protein modifications that regulate gene expression and the activity of a myriad of oncoproteins. Aberrant deacetylase activity can promote or suppress tumorigenesis and cancer metastasis in different types of human cancers, including breast cancer. Sirtuin-1 (SIRT1) is a class-III histone deacetylase (HDAC) that deacetylates both histone and non-histone targets. The often-described ‘regulator of regulators’ is deeply implicated in apoptosis, gene regulation, genome maintenance, DNA repair, aging, and cancer development. However, despite the accumulated studies over the past decade, the role of SIRT1 in human breast cancer remains a subject of debate and controversy. The ambiguity surrounding the implications of SIRT1 in breast tumorigenesis stems from the discrepancy between studies, which have shown both tumor-suppressive and promoting functions of SIRT1. Furthermore, studies have shown that SIRT1 deficiency promotes or suppresses tumors in breast cancer, making it an attractive therapeutic target in cancer treatment. This review provides a comprehensive examination of the various implications of SIRT1 in breast cancer development and metastasis. We will also discuss the mechanisms underlying the conflicting roles of SIRT1, as well as its selective modulators, in breast carcinogenesis.
Micro Magnetic Field Sensors Manufactured Using a Standard 0.18-μm CMOS Process

Micro magnetic field (MMF) sensors developed employing complementary metal oxide semiconductor (CMOS) technology are investigated. The MMF sensors, which are a three-axis sensing type, include a magnetotransistor and four Hall elements. The magnetotransistor is utilized to detect the magnetic field (MF) in the x-axis and y-axis, and four Hall elements are used to sense MF in the z-axis. In addition to emitter, bases and collectors, additional collectors are added to the magnetotransistor. The additional collectors enhance bias current and carrier number, so that the sensor sensitivity is enlarged. The MMF sensor fabrication is easy because it does not require post-CMOS processing. Experiments depict that the MMF sensor sensitivity is 0.69 V/T in the x-axis MF and its sensitivity is 0.55 V/T in the y-axis MF.
Deep Net Features for Complex Emotion Recognition

This paper investigates the influence of different acoustic features, audio-events based features and automatic speech translation based lexical features in complex emotion recognition such as curiosity. Pretrained networks, namely, AudioSet Net, VoxCeleb Net and Deep Speech Net trained extensively for different speech based applications are studied for this objective. Information from deep layers of these networks are considered as descriptors and encoded into feature vectors. Experimental results on the EmoReact dataset consisting of 8 complex emotions show the effectiveness, yielding highest F1 score of 0.85 as against the baseline of 0.69 in the literature.
Diversidade populacional de artrópodes na cultura da abobrinha utilizando armadilhas do tipo moericke e pitfall

A abobrinha italiana e cultivada em todo o territorio nacional e bastante consumida devido as suas caracteristicas nutricionais e a sua praticidade e facilidade de preparo. Os insetos apresentam grande importância na cultura da abobrinha italiana, pois estas dependem de insetos para realizar a polinizacao, alem disso, insetos podem causar danos a planta e aos frutos. O presente trabalho tem por objetivo realizar uma avaliacao da entomofauna presente na cultura da abobrinha durante seu ciclo. Para se realizar o presente estudo, foram implantados quatro canteiros de abobrinha italiana e, durante seu ciclo, foram realizadas tres capturas de artropodes com armadilhas Pitfall e tres coletas com armadilhas Moericke. As coletas foram realizadas quando as plantas estavam com 18, 46 e 65 dias de campo. Em cada coleta foi utilizado duas armadilhas, de cada tipo totalizando seis armadilhas do tipo Pitfall e seis armadilhas do tipo Moericke. Apos a coleta, os insetos foram classificados a nivel de ordem. No estudo realizado, a Ordem Hymenoptera foi a que apresentou a maior quantidade de insetos capturados, totalizando 631. A armadilha do tipo Moericke capturou maior diversidade de insetos no inicio do desenvolvimento da cultura apresentando indice de Shannon de 1,61. A armadilha do tipo Pitfall apresentou maior diversidade de insetos quando a cultura estava em plena floracao, o indice de Shannon foi de 1,30. As armadilhas utilizadas no experimento foram eficientes na captura de artropodes das ordens Coleoptera, Collembola, Diptera, Hemiptera e Hymenoptera A ordem que teve maior numero de individuos capturados foi a ordem Hymenoptera, dessa ordem foram capturados 631 insetos, representando 48,91% dos artropodes amostrados.
Temporary male removal increases extra-pair paternity in eastern bluebirds

The effects of temporary male absence during egg laying on the production of extra-pair young by female eastern bluebirds,Sialia sialis, were examined. Females whose mates were removed for 2 days during egg laying produced more extra-pair young than did females whose mates were present during egg laying. Replacement males were observed at three of 11 nests from which resident males were temporarily removed, and one of 13 extra-pair young was sired by a replacement male. The increased production of extra-pair young when males were removed during egg laying suggests that (1) faced with apparent mate loss, females used copulations in an attempt to attract replacement males to care for young, (2) females were released from the constraints of mate guarding and sought extra-pair copulations, or (3) absence during egg laying reduced the ability of males to devalue rival sperm via supplemental copulations.
Acquiring a first language in adolescence: the case of basic word order in American Sign Language

Abstract Previous studies suggest that age of acquisition affects the outcomes of learning, especially at the morphosyntactic level. Unknown is how syntactic development is affected by increased cognitive maturity and delayed language onset. The current paper studied the early syntactic development of adolescent first language learners by examining word order patterns in American Sign Language (ASL). ASL uses a basic Subject–Verb–Object order, but also employs multiple word order variations. Child learners produce variable word order at the initial stage of acquisition, but later primarily produce canonical word order. We asked whether adolescent first language learners acquire ASL word order in a fashion parallel to child learners. We analyzed word order preference in spontaneous language samples from four adolescent L1 learners collected longitudinally from 12 months to six years of ASL exposure. Our results suggest that adolescent L1 learners go through stages similar to child native learners, although this process also appears to be prolonged.
Emergency Department Text Messaging for Adolescent Violence and Depression Prevention: A Pilot Randomized Controlled Trial

This study’s purpose was to evaluate feasibility and acceptability, obtain preliminary efficacy data, and evaluate predictors of improvement with iDOVE, a technology-augmented violence and depression prevention intervention for high-risk adolescents seen in the emergency department (ED). We conducted a pilot randomized controlled trial (RCT) with 116 English-speaking adolescents (ages 13–17 years), presenting to the ED for any reason, who reported past-year physical peer violence and current depressive symptoms. The cognitive–behavioral therapy- and motivational interviewing-based intervention consisted of a brief in-ED intervention session and 8 weeks of automated text-message daily mood queries and tailored responses. The control was a brief in-ED presentation and twice-weekly text messages on healthy behaviors. Follow-up was conducted at 8 and 16 weeks. Descriptive statistics, bivariate comparisons, mixed-effects longitudinal regression models, and latent class models (LCMs) were calculated. iDOVE had high acceptability and feasibility, with 86% of eligible youth consenting (n = 116), 95% completing 8-week follow-up, and 91% completing 16-week follow-up. High quantitative and qualitative satisfaction were reported by intervention and control participants. Comparing intervention to control, improved depressive symptoms (p = .07) and physical peer violence (p = .01) were observed among the more symptomatic youth in the intervention group (but no difference in symptoms between full intervention and control groups). LCMs showed that intervention responsiveness correlated with lower mood (measured through daily text messages) at Day 7 of the intervention. This RCT of a technology-augmented intervention shows high feasibility and acceptability and a promising signal of reduced violence among the highest-risk participants.
The measurement and meaning of inclusive fitness

Evolutionaryadaptationisageneticprocess,butfortunatelywecanoftenunderstandit,toaﬁrstapproximation, without knowing the geneticdetails. We use what Grafen (1982) called thephenotypicgambit:traitswiththehighestﬁtnesswilltendtobefavoured. Animportantexceptionis in certain kinds of social behaviour, suchas altruism, where population genetic modelsdemonstrate that traits lowering ﬁtness can befavouredbyselection.Inthiscase,thephenotypicgambitcanoftenbepreservedbyintroducingonepieceofgeneticinformation,therelatednessofthealtruisttoitsbeneﬁciary. Althoughthisseeminglypollutesthephenotypicgambitwithgenetics,themainadvantageispreserved,forwestillassumethat we can ignore the genetics underlying theparticulartrait. Theconceptofinclusiveﬁtnessthereforeprovidesacrucialshortcutforstudyingsocialbehaviour,andunderstandinghowtoapplyitisanimportantgoal.Lucasetal. (1996)showedthatamethodofapplying inclusive ﬁtness suggested by Creel(1990)seemstoleadtocertainanomalies.Inthisnote,Iarguethatsuchanomaliesareperhapsnotsurprisingfortworeasons.First,Creel’s(1990)methodhasnotbeenadequatelyjustiﬁed,andislikelytoleadtoerrors.Second,theparadoxthatledCreeltothismethodhasanotherresolution.A little history is required to set the stage.Hamilton(1964)deﬁnedinclusiveﬁtnessastheindividual’sproductionofadultoVspring.
Topic based hierarchical summarisation of Twitter

Twitter has become a rich source of information nowadays. The data generated however is so large in volume that it is not possible to manually go through each and every tweet to understand the context of data. One of the ways to get insight into the bulk of data at hand is to know the topics contained in it. As in the context of Twitter, we define topics to be long-lasting subjects around which the conversations of people revolve, such as sports, music and politics amongst others. However, the topics identified may be large in number and might be cumbersome for human interpretation. Considering these views, in this paper we address the information overload problem of Twitter data and propose a topic based hierarchical summarisation framework for the same. In contrast to imposing restrictions on topic models to depict the hierarchical structure, we propose an algorithm which constructs a topic hierarchy out of any given number of topics. We showcase the effectiveness of the proposed algorithm for the Twitter dataset prepared for Egyptair MS181 flight incident.
Female–offspring communication in a Taiwanese tree frog, Chirixalus eiffingeri (Anura: Rhacophoridae)

Abstract We assessed the roles of visual and olfactory cues in female–tadpole communication in Chirixalus eiffingeri . The mean cumulative time that at least one tadpole was active or begged for food was significantly longer when a female C. eiffingeri was present than when a plastic frog was introduced and when no frog was present. Tadpoles did not respond visually to a female frog physically separated from them by transparent Plexiglas. However, tadpoles were more active in water conditioned by female frogs than in unconditioned water. Tadpole activity was further elevated by water conditioned by a female frog and tadpoles. Tadpoles were more active in water conditioned by male frogs than in unconditioned water, but water conditioned by a male frog and tadpoles did not further elevate tadpole activity. Thus, water conditioned by adults of either sex contains substances that increase tadpole activity, but only females show a synergistic effect with conditioning by tadpoles. Copyright 2002 Published by Elsevier Science Ltd on behalf of The Association for the Study of Animal Behaviour
International Conference on Semantic Systems The Human Face of the Web of Data : A Cross-sectional Study of Labels

Labels in the web of data are the key element for humans to access the data. We introduce a framework to measure the coverage of information with labels. The framework is based on a set of metrics including completeness, unambiguity, multilinguality, labeled object usage, and monolingual islands. We apply this framework on seven diverse datasets, from the web of data, a collaborative knowledge base, open governmental and GLAM data. We gain an insight into the current state of labels and multilinguality on the web of data. Comparing a set of differently sourced datasets can help data publishers to understand what they can improve and what other ways of collecting and data can be adopted.
Survivin regulates chromosome segregation by modulating the phosphorylation of Aurora B during porcine oocyte meiosis

ABSTRACT SURVIVIN is an essential chromosomal passenger complex (CPC) subunit and participates in cell division. In this study, we used porcine oocyte as a model to investigate the roles of Survivin during porcine oocyte maturation. Survivin was highly expressed in germinal vesicle (GV) and germinal vesicle breakdown (GVBD) stages oocytes, mainly localized in the GV at GV stage and on the chromosomes after GVBD. We have used RNA interference to specifically deplete Survivin in oocytes during in vitro maturation (IVM). Immunofluorescence assay showed that Survivin-depleted oocytes failed to produce polar body in meiosisⅠ (failed to complete cytokinesis), and they were arrested in metaphaseⅠwith misaligned chromosomes. The homologous chromosomes in Survivin-depleted oocytes could not be separated normally. Moreover, both the phosphorylation levels of Aurora B and the mRNA level of Mad2L1 related to spindle assembly checkpoint (SAC) was decreased in Survivin-depleted oocytes, which thus inhibited the degradation of Cyclin B1 (CCNB1) to complete meiosis. Taken together, we conclude that Survivin is an important mediator of centromere and midbody docking of Aurora-B as well as its activity and regulates SAC and MPF activity during meiosis in porcine oocytes.
Comparison of Two Different Treatment Protocols Using Systemic and Intratympanic Steroids with and without Hyperbaric Oxygen Therapy in Patients with Severe to Profound Idiopathic Sudden Sensorineural Hearing Loss: A Randomized Controlled Trial

Objectives: This study aimed to investigate the efficacy of simultaneous steroid and hyperbaric oxygen therapy (HBOT) in patients with severe to profound idiopathic sudden sensorineural hearing loss (ISSNHL), which has a poor prognosis. Methods: Sixty patients diagnosed with severe to profound ISSNHL (≥70 dB HL) were randomly divided into two groups in a prospective controlled trial: an oral steroid + intratympanic steroid injection (ITSI) group (control group) and an oral steroid + ITSI + HBOT group (study group). Pure-tone audiometry (PTA) results and word discrimination scores (WDS) were compared between the two groups before treatment and 10 days and 1, 2, and 3 months after treatment. Hearing improvement was assessed using the modified American Academy of Otolaryngology-Head and Neck Surgery criteria. Analyses were by both intention to treat and per protocol. Results: A total of 58 patients completed the 3-month follow-up, and 2 patients in the study group were excluded due to follow-up loss in the per-protocol analysis. In the intention-to-treat and per-protocol analyses, the study group showed significantly better hearing levels than did the control group at 500 Hz (p < 0.05) 1 month after treatment and at 1 kHz (p < 0.05) 3 months after treatment. However, the average PTA values and PTA at 2, 4, and 8 kHz showed no significant difference. WDS improvement was significantly higher in the study group compared to the control group 3 months after treatment by both per-protocol (66.4 ± 13.3 and 56.7 ± 19.1%, respectively; p = 0.029) and intention-to-treat analyses (65.9 ± 14.1 and 56.7 ± 19.1%, respectively; p = 0.035). The sum of complete and partial hearing recovery for the study group was significantly higher than that for the control group by per-protocol analysis (60.7 vs. 33.3%; p = 0.037) and intention-to-treat analysis (60.0 vs. 33.3%; p = 0.038). Conclusion: These results demonstrate that the addition of HBOT to steroid combination therapy does not improve the average PTA values in severe to profound ISSNHL; however, it was associated with a better outcome at 500 Hz 1 month after treatment and, at 1 kHz, WDS 3 months after treatment. The sum of complete and partial hearing recovery was significantly higher for the study group than for the control group.
Ambient Intelligence Environment for Home Cognitive Telerehabilitation

Higher life expectancy is increasing the number of age-related cognitive impairment cases. It is also relevant, as some authors claim, that physical exercise may be considered as an adjunctive therapy to improve cognition and memory after strokes. Thus, the integration of physical and cognitive therapies could offer potential benefits. In addition, in general these therapies are usually considered boring, so it is important to include some features that improve the motivation of patients. As a result, computer-assisted cognitive rehabilitation systems and serious games for health are more and more present. In order to achieve a continuous, efficient and sustainable rehabilitation of patients, they will have to be carried out as part of the rehabilitation in their own home. However, current home systems lack the therapist’s presence, and this leads to two major challenges for such systems. First, they need sensors and actuators that compensate for the absence of the therapist’s eyes and hands. Second, the system needs to capture and apply the therapist’s expertise. With this aim, and based on our previous proposals, we propose an ambient intelligence environment for cognitive rehabilitation at home, combining physical and cognitive activities, by implementing a Fuzzy Inference System (FIS) that gathers, as far as possible, the knowledge of a rehabilitation expert. Moreover, smart sensors and actuators will attempt to make up for the absence of the therapist. Furthermore, the proposed system will feature a remote monitoring tool, so that the therapist can supervise the patients’ exercises. Finally, an evaluation will be presented where experts in the rehabilitation field showed their satisfaction with the proposed system.