Miracle-dz/UniFAR-FTUs huggingface dataset:
Economics Teachers’ Topic Specific Pedagogical Content Knowledge Model for teaching Market Dynamics

The teaching and learning of Market Dynamics (MD) seems to be a challenging topic for teachers and learners. This research aimed to develop an Economics Teachers’ Topic Specific Pedagogical Content Knowledge (ET-TSPCK) Model to improve the teaching of MD. Mavhungas’ Topic Specific Pedagogical Content Knowledge (TSPCK) model was adapted as the base model to identify Economics Topic Specific Pedagogical Content Knowledge (ETSPCK) components for teaching MD. Using a descriptive case study design, a purposeful sample of two economics teachers of the 10 th and 11 th grades were used for the research. While lesson observations were used as data collection method, data were analyzed using a qualitative data analysis technique, namely thematic analysis. Economics teachers’ topic specific knowledge usable for teaching MD were identified and the model “Economics Teachers’ Topic Specific Pedagogical Content Knowledge (ET-TSPCK) model” was developed. In addition, it was found that there exists an inter-relationship among the ETSPCK components. However, the relationship between the teaching strategies and the components of Curriculum knowledge were not connected and fully developed in the participating teachers. The model provides insights into the implementation of the Curriculum Assessment Policy Statement (CAPS) with reference to the teaching of MD hence, suggesting ways in which the teaching of the topic could be improved. https://doi.org/10.26803/ijlter.19. 7.18
Chemical composition and antifungal potential of Iranian propolis against Candida krusei strains

Propolis is known to have biological properties against numerous microorganisms of clinical interest. This is important, because all Candida krusei (C. krusei) isolates are resistant to azole drugs. The aims of this study were to determine the chemical composition and antifungal efficacy of Iranian propolis against C. krusei strains isolated from patients with cutaneous and mucosal candidiasis. Ethanolic extract of propolis (EEP) was prepared from propolis originating from Mazandaran province, and submitted to chemical analysis by high-resolution gas chromatography coupled to mass spectrometry. Additionally, the EEP was tested for its ability to inhibit yeasts by determination of the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) using broth microdilution method (M27-A3 protocol) with some modifications. Phenolic acids (78.2%) were the major components of Iranian propolis. The EEP exhibited MIC values ranging from 2 to 20 mg/ml and MFC values between 4 and 25 mg/ml. The most fungal susceptibility was associated with the nail isolates (mean MIC value: 7.8 mg/ml), followed by the oral isolates (mean MIC value: 9.7 mg/ml) and vaginal isolates (mean MIC value: 11.7 mg/ml). The results showed that Iranian propolis has strong anti-C. krusei activity and should be considered as a promising candidate to treat nail, oral and vaginal candidiasis.
Feeling/Making Democracy: Emotions of Candidates Contesting Dehradun Municipal Elections

ABSTRACT Emotions and sentiments are central to explanations of how actual living democracies work, that is, the sustaining and reconfiguring of practices, relations and common-senses that constitute them. Elections are moments of heightened emotions, when democracy breathes life into the streets and pulses through people’s veins. While studies in anthropology and political science have shed light on the ways that voters are recruited by and experience the passionate and sensuous elements of elections, and democracies more broadly, the emotions of candidates and the politicians they become have largely escaped scrutiny. The value of an emotionally attuned reading of elections is demonstrated through the narratives of women candidates in Dehradun’s municipal elections in North India. The ways candidates feel, and in the process make democracy, illuminate unrecognised factors in the shaping of the political.
Modeling the effect of ultraviolet radiation on the photosynthetic potential of Prochlorococcus and Synechococcus cyanobacteria

We used mathematical models of photosynthesis to quantify the effects of ultraviolet (UV) radiation on the photosynthetic potential of Prochlorococcus and Synechococcus marine cyanobacteria living at 0 degrees and 40 degrees N/S latitude. We show that UV is an environmental stressor for these organisms near the ocean surface, accounting for roughly two-thirds of the potential photo synthetic inhibition. Prochlorococcus showed a higher inhibition and integrated photo synthetic potential throughout the water column than Synechococcus, since the former is more vulnerable to UV damage at the surface and more successful at greater depths compared to the latter. The maximum photosynthetic activity was reached beneath the photoactive zone, largely due to the harmful effects of UVA. UV inhibition varies with latitude, due to variability in repair capacity for Synechococcus, and the existence of more diverse mechanisms of acclimation to irradiance and temperature for Prochlorococcus. The lowest photoinhibition is estimated to occur at 0 degrees latitude, since the interactive effects of high temperature and irradiance have a positive effect on photo acclimation to UV damage.
Digenic Variants in the FGF21 Signaling Pathway Associated with Severe Insulin Resistance and Pseudoacromegaly

Abstract Insulin-mediated pseudoacromegaly (IMPA) is a rare disease of unknown etiology. Here we report a 12-year-old female with acanthosis nigricans, hirsutism, and acromegalic features characteristic of IMPA. The subject was noted to have normal growth hormone secretion, with extremely elevated insulin levels. Studies were undertaken to determine a potential genetic etiology for IMPA. The proband and her family members underwent whole exome sequencing. Functional studies were undertaken to validate the pathogenicity of candidate variant alleles. Whole exome sequencing identified monoallelic, predicted deleterious variants in genes that mediate fibroblast growth factor 21 (FGF21) signaling, FGFR1 and KLB, which were inherited in trans from each parent. FGF21 has multiple metabolic functions but no known role in human insulin resistance syndromes. Analysis of the function of the FGFR1 and KLB variants in vitro showed greatly attenuated ERK phosphorylation in response to FGF21, but not FGF2, suggesting that these variants act synergistically to inhibit endocrine FGF21 signaling but not canonical FGF2 signaling. Therefore, digenic variants in FGFR1 and KLB provide a potential explanation for the subject’s severe insulin resistance and may represent a novel category of insulin resistance syndromes related to FGF21.
Response of Ross 308 and 708 broiler strains in growth performance and lipid metabolism to diets containing tributyrate glycerides

Abstract: Tributyrin is a butyrate glyceride, shown to have positive effects on broiler performance. This study investigated the differences in growth performance between Ross 308 and Ross 708 birds, and compared how each strain responds to tributyrin supplementation. Two-hundred-and-forty-day-old Ross 308 and 240-d-old Ross 708 chicks were divided and fed a basal diet, or diets supplemented with low or high levels of tributyrin for 35 d. Neither strain nor tributyrin supplementation had an effect on average daily gain or feed:gain (P > 0.05). All Ross 708 birds had significantly decreased relative abdominal fat weight at 3 and 5 wk of age compared with Ross 308 birds of the same treatment (P ≤ 0.05). Tributyrin supplementation only decreased relative abdominal fat weight compared with controls in Ross 708 birds at 5 wk of age (P ≤ 0.05). Ross 708 control birds had significantly higher breast muscle fat deposition than Ross 308 controls (P ≤ 0.05), and tributyrin lowered this deposition in both strains (P ≤ 0.05). Significant differences in hepatic expression of genes associated with lipid metabolism were observed between strains, and with tributyrin supplementation (P ≤ 0.05). These results support the modulation of lipid metabolism by tributyrin, and show different broiler strains responded uniquely to tributyrin supplementation.
NGF-TRKA ENDOSOME DYNAMICS, SIGNALING AND FUNCTION IN SYMPATHETIC NEURON DENDRITES

s Lehigh.K. M, Ginty, D.D. (2016) NGF-TrkA endosome dynamics, signaling, and function in dendrites. HHMI Science Meeting. HHMI Headquarters, Chevy Chase, MD, February 3, 2016. (Poster) Lehigh.K. M, Ginty, D.D. (2014) NGF-TrkA signaling endosome dynamics and signaling in dendrites. Axon Guidance, Synapse Formation, and Regeneration. Cold Spring Harbor Laboratory, NY, September 17, 2014. (Talk) Lehigh.K. M, Ginty, D.D. (2013) NGF-TrkA signaling endosome dynamics and signaling in dendrites. Gordon Research Conferences: Neurotrophic Factors, Newport, RI, June 2-7, 2013. (Poster) Lehigh.K. M, Ginty, D.D. (2013) NGF-TrkA signaling endosome dynamics and signaling in dendrites. Johns Hopkins Neuroscience Lab Lunch Seminar. Baltimore, MD. February 5, 2013. (Talk) Teaching Experience Fall 2015 Neuroscience: HST130/Neuro200 (Harvard Medical School Graduate/Medical student course) Position: Teaching assistant; wrote and graded exams and led discussion sections Course director: Dr. John Assad Fall 2014 Human Genetics MCB 101 Harvard College Undergraduate Course. Position: Teaching fellow; responsible for all evaluation and development of each student’s scientific writing skills Professor: Dr. Craig Hunter Spring 2011 Neuroanatomy Section of Nervous system & Special Senses (Medical student course) Position: Teaching assistant; led a small group through wet lab neuroanatomy dissections Class coordinators: Dr. Mary Blue, Dr. Larry Schramm and Dr. Mary Ann Wilson Fall 2010 Neuroscience and Cognition I (Johns Hopkins University School of Medicine Graduate Course) Position: Teaching assistant; wrote lecture notes and ran review sessions Course Director: Dr. Seth Blackshaw
Construction of Synthetic Intact Human Parathyroid Hormone Gene and Testing the Transformation Efficiency and Expression of it in E. coli strains

human parathyroid hormone gene (hPTH gene) is responsible for preproparathyroid hormone production (biologically inactive hormone) which further modified to form the biologically active hormone, a synthetic hPTH gene with 289bp which cod for active intact hPTH was constructed by Five long primers by splicing overlap extension PCR (SOE), the gene contain a de generated codon, and have two recognition site of restriction enzymes in both ends of the Gene, and a stop codon. The synthetic hPTH gene was transformed in two E. coli strains DH5α and BL21 (DE3) with transformation efficiency6.6 * 10 6 and 3.4 * 10 6 for both isolatesrespectively. And the transformation of gene was detected by extraction of constructed plasmid and amplification of cloning gene on it, the expression of the cloning gene in the BL21 (DE3) was detected by performing Real Time PCR which gave a Ct value of about (23.46). That makes the synthetic gene suitable for direct expression of human active protein inside the bacterial cells.
Investigating User Perceptions of Mobile App Privacy: An Analysis of User-Submitted App Reviews

Mobile devices and third-party applications are used by over 4.5 billion people worldwide. Third-party applications often request or even require authorized access to personal information through mobile device components. Application developers explain the need for access in their privacy policies, yet many users are concerned about the privacy implications of allowing access to their personal information. This article explores how user perceptions of privacy affect user sentiment by analyzing over five million user-submitted text reviews and star ratings collected over a four-year period. The authors use supervised machine learning to classify privacy and non-privacy-related reviews. The authors then use natural language processing sentiment analysis to compare differences between the groups. Additionally, the article explores various aspects of both privacy and non-privacy-related reviews using self-reported measurements such as star rating and helpfulness tags.
The generation and the characterization of the TASK-3 knockout mice

Excitable cells use specific combinations of ion channels in order to set their electrical properties. The recent discovery of the two pore domain potassium channels (K2P) revealed the molecular substrates for resting K+ currents in neuronal cells. To date fifteen members of the K2P family, grouped into six distinct subfamilies (TWIK, THIK, TREK, TASK, TALK and TRESK) have been identified and characterized, some of them being highly expressed in the central and peripheral nervous system. K2P channels generate leak K+ currents which contribute to the resting membrane potential and play important roles in modulating neuronal excitability. K2P subunits can assemble as homodimers or heterodimers when coexpressed in neurons. There are no pharmacological agents that selectively block the K2P channel subtypes. Thus, it is difficult to dissect their contribution to the leak K+ background current. The TASK (TWIK-related acid-sensitive K+ channel) subfamily consists of TASK-1, TASK-3 and the non-functional TASK-5 channels. TASK-1 and TASK-3 channels are expressed in the brain, can sense physiologically relevant changes in extracellular pH and are modulated by neurotransmitters. In this thesis I analyzed the expression of TASK-1 and TASK-3 genes in the adult mouse brain. The TASK-1 gene has a restricted expression pattern, with highest level in cerebellar granule cells whereasTASK-3 gene has a strong expression in all brain regions. To understand the role of TASK-3 in the K+ leak conductance and in neuronal excitability I generated TASK-3 knockout mice and undertook some analysis of their phenotype. The K+ leak current of cerebellar granule cells was reduced to 50% and granule cells fired fewer action potentials in response to current injection. Despite these strong changes on the electrophysiological level, the motor behaviour of the TASK-3 knockout mice was unchanged, indicating possible compensatory mechanisms. The TASK-3 knockout mice will be useful for investigating: the contribution of TASK-3 channels to the leak currents in particular neuronal cell types (e.g. cerebellar granule cells, thalamic relay cells), the heteromeric assembly between TASK-1 and TASK-3 subunits in vivo, the involvement of TASK-3 channels in thalamocortical relay neurons in initiating arousal, their contribution to the anesthesia produced by inhalational anesthetics, their role in regulating apoptosis in developing cerebellar granule cells, their possible role in protection from brain ischemia, their contribution to homeostatic plasticity in cerebellar granule cells and their contribution to blood pressure regulation and blood oxygen sensing.
Activité cytotoxique in vitro et in vivo d'un extrait enrichi d'Helleborus caucasicus et mode d'action sur des cellules du cancer du poumon non-à-petites cellules

Le cancer du poumon occupe la premiere position en termes de frequence de deces imputables au cancer. La majorite des cas de cancer du poumon diagnostiques sont des cas de cancers du poumon dits « non-a-petites cellules » (CPNPC). Il n’existe actuellement aucun traitement capable d’eradiquer completement le CPNPC ce qui lui confere le statut de maladie incurable. Ce projet avait pour objectif principal d’evaluer le potentiel anticancereux d’un extrait enrichi d’une plante endemique de la Georgie, Helleborus caucasicus, pour traiter le CPNPC. L’activite anti-tumorale de cet extrait a ete evaluee in vitro au niveau cellulaire et moleculaire dans des cellules d’adenocarcinome pulmonaire humain A549 et in vivo chez des souris C57BL/6 NCrl porteuses de tumeur du carcinome pulmonaire de Lewis. Les resultats ont montre que l’extrait etudie possedait une activite anticancereuse pertinente in vitro et in vivo et ainsi, qu’il constituait une strategie therapeutique potentielle dans le traitement du CPNPC.
A network of MAP-Kinase pathways and transcription factors regulates cell-to-cell communication and cell wall integrity in Neurospora crassa

Maintenance of cell integrity and cell-to-cell communication are fundamental biological processes. Filamentous fungi, such as Neurospora crassa, depend on communication to locate compatible cells, coordinate cell fusion, and establish a robust hyphal network. Two MAP-Kinase pathways are essential for communication and cell fusion in N. crassa; the Cell Wall Integrity/MAK-1 pathway and the MAK-2 (signal response) pathway. Previous studies have demonstrated several points of cross talk between the MAK-1 and MAK-2 pathways, which is likely necessary for oordinating chemotropic growth toward an extracellular signal, and then mediating cell fusion. Canonical MAP-Kinase pathways begin with signal reception and end with a transcriptional response. Two transcription factors, ADV-1 and PP-1, are essential for communication and cell fusion. PP-1 is the conserved target of MAK-2, while it is unclear what targets ADV-1. We did RNAseq on Δadv-1, Δpp-1, and wild-type cells and found that ADV-1 and PP-1 have a shared regulon including many genes required for communication, cell fusion, growth, development, and stress response. We identified ADV-1 and PP-1 binding sites across the genome by adapting the in vitro method of DNA-Affinity Purification sequencing (DAP-seq) for N. crassa. To elucidate the regulatory network, we misexpressed each transcription factor in each upstream MAPK deletion mutant. Misexpression of adv-1 was sufficient to fully suppress the phenotype of the Δpp-1 mutant and partially suppress the phenotype of the Δmak-1 mutant. Collectively, our data demonstrate that the MAK-1-ADV-1 and MAK-2- PP-1 pathways form a tight regulatory network that maintains cell integrity and mediates communication and cell fusion.
Testing the Relationship of Burnout to Job Satisfaction for Psychiatric Rehabilitation Practitioners beyond Controlled-for Background Variables

A Psychiatric Rehabilitation Practitioner (PRP) is a less-often studied rehabilitation counselor who works specifically with mental health patients. An on-line survey was filled out by 1,635 PRPs who provided background, burnout and job satisfaction data. Full data was available for 819 PRPs. Background data collected included: gender, race, age, highest education level, length of service, and salary. The study hypothesis that burnout would be negatively related to job satisfaction beyond the controlled-for background variables was supported. Although only a limited amount of job satisfaction variance was explained, the study results support continued study of burnout and job satisfaction for PRPs and other mental health professionals.
Highly tunable topological system based on PbTe-SnTe binary alloy

Despite lots of research activities on topological materials, a highly tunable system is yet to be realized as a material platform for exploration of versatile magneto-/opto-/thermoelectronic properties. The authors followed an important scheme for topological phase transitions proposed by S. Murakami et al. and could find a highly tunable topological system based on PbTe-SnTe alloy doped with In. By varying parameters, Pb/Sn ratio and In doping, they can tune the system from trivial to topological-crystalline insulators across a finite range of materials, where the system shows polar distortion and topological semi-metal behaviors with low-carrier density, high mobility and anomalous (in-plane as well as out-of-plane field) Hall effects.
First example of hybridisation between two Australian figs (Moraceae)

Abstract. The chance discovery of an unusual Ficus specimen near Katherine in the Northern Territory prompted an investigation into hybridisation between two morphologically distinct endemic Australian sandpaper figs, Ficus aculeata A.Cunn. ex Miq. and F. coronulata Miq. In this study, genome-wide scans and morphological measurements were used to investigate the perceived hybridisation by using herbarium and freshly collected samples. Most of the putative hybrids displayed a wide variety of intermediate morphology and some individuals had characteristics consistent with the description of a third species, F. carpentariensis D.J.Dixon. Both genomic and morphometric results provided evidence of naturally occurring hybridisation events within Ficus. Additionally, the findings from this study showed possible taxonomic issues within the Northern Australian sandpaper figs that warrant further investigation.
Isolation and Characterization of Antibiotic Resistance Bacteria in Hospital Effluents

Abstract :-Antibiotic resistance has become a major clinical and public health problem within the lifetime of the peoples . The current worldwide increase in resistant bacteria and simultaneously, the downward trend in the development of new antibiotics have serious implications. This study isolated and characterized different antibiotic resistance bacteria present in the hospital effluents of Kushtia district in Bangladesh using selective growth medium in presence of amoxicillin, tetracycline and penicillin at different concentration. Salmonella spp, Escherichia coli and Shigella were found to be resistant to these antibiotics. It also finds that amoxicillin is more resistant to the microorganisms as compared to other two antibiotics. This study also showed that the gram-negative acquired resistant to antibiotics rather than gram-positive bacteria in the hospital effluents. Therefore a high level of antibiotic resistance bacteria is present in the hospital effluents which can be a big health hazard to the human beings.
Forecasting India's Crime Rate

- Because of advancement in technologies like data analytics and criminal sciences, crime forecasting is made possible. Crime forecasting plays a major role in making decisions and planning strategies to reduce the number of crimes. Our main aim is to compare the forecasting models which are “time series model-ARIMA (Auto-Regressive Integrated Moving Average)” and “regression model-Linear Regression”. The data we are using for this research has crime count value from 2001-2013. After the execution, time series model’s accuracy rate is around 96% and the other is about 60% from which we can conclude that former is better than the latter.
Fault’s hydraulic diffusivity enhancement during injection induced fault reactivation: application of pore pressure diffusion inversions to laboratory injection experiments

In situ observations of fluid induced fault slip reactivation, as well as the analysis of induced seismicity have demonstrated the complexity of fluid–fault interactions under geological conditions. If fluid flow commonly reactivates faults in the form of aseismic slip or earthquakes, the resulting shear deformation causes strong modifications of the hydraulic properties. In this context, the relationship between slip front and fluid front on deep faults remains not fully understood. In this study, we investigate shear induced fluid flow and hydraulic diffusivity enhancement during fracture shearing in the laboratory. We use a series of injection reactivation tests, conducted under triaxial conditions, at different confining pressures (30, 60 and 95 MPa). The evolution of the fluid pressure along the saw-cut Andesite rock sample was monitored by two pressure sensors, at two opposite locations of the experimental fault. We estimate the history of the effective hydraulic diffusivity (and its associated uncertainties) governing the experimental fault, using the pressure history at two points on the fault. For this, we develop a deterministic and a probabilistic inversion procedure, which is able to reproduce the experimental data for a wide time range of the different experiments. In this study, the hydraulic diffusivity increases by one order of magnitude through the injection experiment. Hydraulic diffusivity changes are mainly governed by the reduction of the effective normal stress acting on the fault plane, with a second-order effect of the shear slip.