Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence rates and risk factors for mental health difficulties in adolescents aged 16 and 17 years living in rural Ireland

Objective This study sought to ascertain the prevalence rates and risk factors for a range of mental health difficulties, including suicidal ideation/self-harm among 16 and 17-year-old rural Irish adolescents, a vulnerable group in transition from childhood to adulthood. Method Adolescents (n=237) took part in this cross-sectional study. Participants completed a questionnaire compendium consisting of generic questions on demographic information, use of mental health services and four normed questionnaires: The Youth Self-Report, the Children’s Depression Inventory, the Coping Inventory for Stressful Situations-Adolescent and The Family Assessment Device. Results We found that 16.9% of adolescents reported clinically significant mental health difficulties. Significant gender differences were found on internalising and externalising difficulties. There were no gender differences in suicidal ideation or self-harm. Only 3.4% of adolescents were receiving professional help for mental health difficulties. Multiple regression analyses revealed that family dysfunction, emotion-focussed coping and poor academic competence were significant predictors of poorer mental health difficulties in both genders. Family dysfunction was the strongest predictor of mental health difficulties in males. Among females, emotion-focussed coping was the strongest predictor of internalising difficulties and depression. Social diversion (social support) was predictive of less internalising difficulties and depression for females. Conclusion The study shows that a significant number of Irish 16 and 17 year olds have mental health difficulties, yet very few are receiving treatment. Emotion-focussed coping, family dysfunction, poor academic competence and less social support were important predictors of mental health difficulties. A new finding is the stronger association that family dysfunction has with poorer mental health in males than females, when controlling for academic competence and coping skills. The findings may have implications for psychological interventions.
Corrective ventilation strategies in delivery room resuscitation of preterm infants

Corrective ventilation strategies (CVS) during neonatal resuscitation and stabilisation (R&S) are taught through the MRSOPA mnemonic: Mask adjustment, Repositioning airway, Suctioning, Opening the mouth, Increasing inspiratory Pressure, and Alternative airway. The aim was to examine the use of CVS and to investigate the relationship between MRSOPA strategies and intubation of very preterm infants <32 weeks’ gestation in the delivery room.
Prototype-based Models for the Supervised Learning of Classification Schemes

Abstract An introduction is given to the use of prototype-based models in supervised machine learning. The main concept of the framework is to represent previously observed data in terms of so-called prototypes, which reflect typical properties of the data. Together with a suitable, discriminative distance or dissimilarity measure, prototypes can be used for the classification of complex, possibly high-dimensional data. We illustrate the framework in terms of the popular Learning Vector Quantization (LVQ). Most frequently, standard Euclidean distance is employed as a distance measure. We discuss how LVQ can be equipped with more general dissimilarites. Moreover, we introduce relevance learning as a tool for the data-driven optimization of parameterized distances.
Circulating insulin‐like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutrition

Insulin‐like growth factor‐I (IGF‐I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF‐I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF‐I concentrations and melanoma risk. A nested case–control study of 1,221 melanoma cases and 1,221 controls was performed in the European Prospective Investigation into Cancer and Nutrition cohort, a prospective cohort of 520,000 participants recruited from 10 European countries. Conditional logistic regression was used to estimate odds ratios (ORs) for incident melanoma in relation to circulating IGF‐I concentrations, measured by immunoassay. Analyses were conditioned on the matching factors and further adjusted for age at blood collection, education, height, BMI, smoking status, alcohol intake, marital status, physical activity and in women only, use of menopausal hormone therapy. There was no significant association between circulating IGF‐I concentration and melanoma risk (OR for highest vs lowest fifth = 0.93 [95% confidence interval [CI]: 0.71 to 1.22]). There was no significant heterogeneity in the association between IGF‐I concentrations and melanoma risk when subdivided by gender, age at blood collection, BMI, height, age at diagnosis, time between blood collection and diagnosis, or by anatomical site or histological subtype of the tumour (Pheterogeneity≥0.078). We found no evidence for an association between circulating concentrations of IGF‐I measured in adulthood and the risk of melanoma.
Validity and reliability of the Mandarin version of Patient Dignity Inventory (PDI-MV) in cancer patients

Nurses play an important role in maintaining patients’ dignity. How to measure patients’ dignity and dignity-related distress is an important issue in nursing care. Use of a reliable and valid tool assessing dignity-related distress in patients is necessary. The study investigated the validity and reliability of the Mandarin Version of the Patient Dignity Inventory (PDI-MV) in cancer patients. The Patient Dignity Inventory (PDI) was translated into the Mandarin language using forward and back translation. A convenience sample of 125 adult cancer patients was recruited from the oncology ward of a medical center in southern Taiwan. Factor analysis with principal axis factoring extraction method and oblique rotation (promax) was used to assess the construct validity. Concurrent validity was established using the Patient Health Questionnaire-9 (PHQ-9), Mandarin version of Demoralization Scale (DS-MV) and the Rosenberg Self-Esteem Scale (RSES). Internal consistency was used to examine the reliability. Data were collected from February to May 2016. As a result of the factor analysis, four factors, including existential distress, loss of support and sense of meaning, symptom distress, and loss of autonomy. Concurrent validity showed that the PDI-MV was significantly correlated with the PHQ-9 (r = 0.25–0.54), DS-MV (r = 0.30–0.58) and the RSES (r = - 0.08 to—0.30), Cronbach’s alpha coefficients for the PDI-MV and four factors were 0.95, 0.95, 0.84, 0.83, and 0.89 respectively. The PDI-MV is a psychometrically sound instrument assessing a broad range of dignity-related distress issues in cancer patients.
Inverting Thermal Degradation (iTD) of Paper Using Chemi- and Physi-Sorbed Modifiers for Templated Material Synthesis

Fibrous cellulosic materials have been used as templates for material synthesis or organization via thermal degradation of the cellulose. Most of these methods, however, fail to exploit fiber organization, in part due to loss of structure with processing. Herein, we demonstrate that chemi- and physi-sorbed modifiers of cellulose alters the thermal degradation mechanism allowing for controlled deposition of oxide and carbon (incomplete combustion) along the original paper fiber network. We demonstrate that the degradation of the cellulose fibers depends on the amount of physisorbed material due, in part, to effect on the propagation of the ignition event. From the distribution of the residual elements and shape of the deposits, we can infer that the thermal degradation process depends on the nature, and concentration, of filler(s) or occluded.
Survey examining the views of Adult Psychiatry Consultants and Senior Registrars regarding ADHD

Objectives Attention deficit hyperactivity disorder (ADHD) persists into adulthood in ∼2/3 of patients, yet services for adults are lacking in Ireland. This may involve negative attitudes and beliefs as to the validity of ADHD or lack of knowledge and training in its treatment. The objectives of this study are to explore the views of Adult Psychiatrists regarding ADHD knowledge and the treatment options available and pursued in Ireland. Methods A questionnaire was constructed based on the stated aims of the study, and was either posted, emailed or handed to 400 Consultants and Senior Registrars throughout the Republic of Ireland between February and December 2011. A total of 92 questionnaires were returned (23%); one was excluded from analysis due to insufficient information entered by the respondent. Results Seventy-five per cent of respondents correctly estimated the prevalence rates of adult ADHD to be under 3%, but stated it is currently under-diagnosed (77%). Seventy-four per cent indicated that Adult ADHD should be a diagnostic category in the Diagnostic and Statistical Manual, 5th Edition (DSM V). Sixty-six per cent of respondents were willing to accept referrals of childhood ADHD for ongoing care and a similar number for new ADHD assessments (61%). Less than half (42%) surveyed had actually diagnosed ADHD and of these, only 33% felt confident in managing ADHD in their patients. Conclusions Although there is a general willingness to offer services for new and existing ADHD cases and a recognition that Adult ADHD is valid and under-diagnosed, the low confidence levels when treating ADHD and the perception of under-diagnosis suggests a role for further training and links between child and adult services.
tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish

The TP53 tumor-suppressor gene is mutated in >50% of human tumors and Li-Fraumeni patients with germ line inactivation are predisposed to developing cancer. Here, we generated tp53 deleted zebrafish that spontaneously develop malignant peripheral nerve-sheath tumors, angiosarcomas, germ cell tumors, and an aggressive Natural Killer cell-like leukemia for which no animal model has been developed. Because the tp53 deletion was generated in syngeneic zebrafish, engraftment of fluorescent-labeled tumors could be dynamically visualized over time. Importantly, engrafted tumors shared gene expression signatures with predicted cells of origin in human tissue. Finally, we showed that tp53del/del enhanced invasion and metastasis in kRASG12D-induced embryonal rhabdomyosarcoma (ERMS), but did not alter the overall frequency of cancer stem cells, suggesting novel pro-metastatic roles for TP53 loss-of-function in human muscle tumors. In summary, we have developed a Li-Fraumeni zebrafish model that is amenable to large-scale transplantation and direct visualization of tumor growth in live animals.
Receive Antenna Selection and Hybrid Precoding for Receive Spatial Modulation in Massive MIMO Systems

Recently, a receive spatial modulation (RSM) for massive multiple-input-multiple-output operating in millimeter wave (mmWave) was introduced with the purpose of simplifying user terminal circuit by employing only one radio-frequency chain and attaining high spectral efficiency by exploiting the receive spatial dimension. However, when RSM is applied in a mmWave channel, it demands a challenging receive antenna selection (RAS) procedure. On the other hand, the power consumption at the transmitter side is high when a full digital (FD) precoder is envisioned. We consider the joint problem of RAS and precoder designs based low complexity hybrid architecture. For the sake of simplicity, we divide this problem into two subproblems. First, we design the RAS assuming FD precoder, and then, we design the hybrid precoder. We propose two novel and efficient RAS methods. First, we formulate the RAS as non-convex optimization problem. Then, we convert it into a convex optimization problem by introducing novel lower bounds and relaxing non-convex constraints. Second, we provide sequential algorithms that approach the optimal selection where we (add/remove) one (good/poor) antenna per iteration. We propose novel zero forcing hybrid precoder based convex optimization that maximizes the received power. We prove that the proposed precoder is optimal when the channel is highly spatially sparse. The proposed designs have been compared with the best known methods in terms of average mutual information and energy efficiency showing significant improvements.
24S-Hydroxycholesterol Correlates With Tau and Is Increased in Cerebrospinal Fluid in Parkinson's Disease and Corticobasal Syndrome

24S-hydroxycholesterol (24OHC) and Tau are produced in neuronal cells and neurodegeneration leads to increased flux of both of them into cerebrospinal fluid (CSF). In the present study, CSF levels of 24OHC and 27S-hydroxycholesterol (27OHC) along with those of Tau, P-Thr181-Tau and Aβ42 were measured in patients with early Parkinson's disease (PD), Corticobasal syndrome (CBS), Corticobasal Degeneration (CBD), and controls. Using mouse models with increased or no formation of Tau protein and increased production of 24OHC, we have also tested the hypothesis that there is a direct association between neuronal turnover of 24OHC and Tau. The levels of 24OHC are increased, at a group level, in patients with PD or CBS. We found significant correlations between levels of 24OHC and Tau or P-Thr181-Tau in CSF from patients with PD, CBS or CBD. There were no similar correlations between 24OHC and Aβ42 in CSF from these patients. The neuronal levels of 24OHC were not altered in Tau knockout or Tau overexpressing mice. Vice versa, Tau species levels were not changed in Cyp46 overexpressing mice with increased neuronal levels of 24OHC. We conclude that the strongly correlative fluxes of 24OHC and Tau from neuronal cells to CSF are likely to be secondary to neurodegeneration and not due to direct interaction between the two factors. We suggest that this high correlation reflects a rapid neurodegeneration of specific neuronal subtypes with simultaneous release of 24OHC and Tau into the CSF.
Development and in vitro evaluation of solid dispersions as strategy to improve albendazole biopharmaceutical behavior.

AIM Solid dispersions using Poloxamer 407 as carrier were developed to improve albendazole (ABZ) solubility and dissolution profiles. METHODS ABZ/poloxamer solid dispersions were prepared, and dissolution profiles were mathematically modeled and compared with physical mixtures, pharmaceutical ABZ and a commercial formulation. RESULTS Poloxamer 407 increased exponentially ABZ solubility, in about 400% when 95% w/w of polymer compared with its absence. Solid dispersions initial dissolution rate was three to 20-fold higher than physical mixtures, the drug and the commercial formulation. All the solid dispersions required less than 2.2 min to reach an 80% of ABZ dissolution, while the commercial formulation needed around 40 min. CONCLUSION Solid dispersions improved ABZ solubility and dissolution rate, which could result in a faster absorption and an increased bioavailability.
Augmentation Cystoplasty of Diseased Porcine Bladders with Bi-Layer Silk Fibroin Grafts.

IMPACT STATEMENT The search for an ideal "off-the-shelf" biomaterial for augmentation cystoplasty remains elusive and current scaffold configurations are hampered by mechanical and biocompatibility restrictions. In addition, preclinical evaluations of potential scaffold designs for bladder repair are limited by the lack of tractable large animal models of obstructive bladder disease that can mimic clinical pathology. The results of this study describe a novel, minimally invasive, porcine model of partial bladder outlet obstruction that simulates clinically relevant phenotypes. Utilizing this model, we demonstrate that acellular, bi-layer silk fibroin grafts can support the formation of vascularized, innervated bladder tissues with functional properties.
The changing landscape of vancomycin-resistant Enterococcus faecium in Australia: a population-level genomic study

Background Vancomycin-resistant Enterococcus faecium (VREfm) represent a major source of nosocomial infection worldwide. In Australia, there has been a recent concerning increase in bacteraemia associated with the vanA genotype, prompting investigation into the genomic epidemiology of VREfm. Methods A population-level study of VREfm (10 November-9 December 2015) was conducted. A total of 321 VREfm isolates (from 286 patients) across Victoria State were collected and sequenced with Illumina NextSeq. SNPs were used to assess relatedness. STs and genes associated with resistance and virulence were identified. The vanA-harbouring plasmid from an isolate from each ST was assembled using long-read data. Illumina reads from remaining isolates were then mapped to these assemblies to identify their probable vanA-harbouring plasmid. Results vanA-VREfm comprised 17.8% of isolates. ST203, ST80 and a pstS(-) clade, ST1421, predominated (30.5%, 30.5% and 37.2%, respectively). Most vanB-VREfm were ST796 (77.7%). vanA-VREfm were more closely related within hospitals versus between them [core SNPs 10 (IQR 1-357) versus 356 (179-416), respectively], suggesting discrete introductions of vanA-VREfm, with subsequent intra-hospital transmission. In contrast, vanB-VREfm had similar core SNP distributions within versus between hospitals, due to widespread dissemination of ST796. Different vanA-harbouring plasmids were found across STs. With the exception of ST78 and ST796, Tn1546 transposons also varied. Phylogenetic analysis revealed Australian strains were often interspersed with those from other countries, suggesting ongoing cross-continental transmission. Conclusions Emerging vanA-VREfm in Australia is polyclonal, indicating repeat introductions of vanA-VREfm into hospitals and subsequent dissemination. The close relationship to global strains reinforces the need for ongoing screening and control of VREfm in Australia and abroad.
Totally Implantable Bidirectional Neural Prostheses: A Flexible Platform for Innovation in Neuromodulation

Implantable neural prostheses are in widespread use for treating a variety of brain disorders. Until recently, most implantable brain devices have been unidirectional, either delivering neurostimulation without brain sensing, or sensing brain activity to drive external effectors without a stimulation component. Further, many neural interfaces that incorporate a sensing function have relied on hardwired connections, such that subjects are tethered to external computers and cannot move freely. A new generation of neural prostheses has become available, that are both bidirectional (stimulate as well as record brain activity) and totally implantable (no externalized connections). These devices provide an opportunity for discovering the circuit basis for neuropsychiatric disorders, and to prototype personalized neuromodulation therapies that selectively interrupt neural activity underlying specific signs and symptoms.
Comparative Effectiveness of Generic Latanoprost Versus Branded Prostaglandin Analogs for Primary Open Angle Glaucoma

ABSTRACT Purpose: The purpose of the study is to determine the comparative effectiveness of generic latanoprost (GL) to its branded (BL) counterpart and other brand-name prostaglandin analogs (bPGAs) in preventing the need for additional therapy in the treatment of primary open angle glaucoma (POAG). Methods: Retrospective cohort study using US commercial medical claims data. All new POAG patients from 2000 to 2015 who initiated treatment with either GL or BL were included. Exclusion occurred for having less than 2 years of time in the plan prior to diagnosis, previous use of glaucoma medications, or any diagnosis of glaucoma other than POAG at any time. Analyses compared GL to BL and also to those who received any branded PGA after 2011 (when the generic became available). Cox proportional hazard regression was used to assess the hazards of filling a prescription for a second IOP-lowering medication or having surgical intervention, individually and either outcome combined. Results: A total of 6317 and 4150 POAG patients were treated with GL and BL, respectively. After 2010, 6317 GL and 3703 brand-name prostaglandin analog (bPGA) POAG patients met criteria for inclusion. After adjustment, compared to BL, the GL conferred a reduced hazard of having a glaucoma procedure performed (hazard ratio [HR] = 0.72, 95% CI: 0.62–0.84, p < 0.001) and the combined outcome (HR = 0.90, 95% CI: 0.83–0.97, p = 0.006) but was not associated with having a second IOP medication (HR = 0.95, 95% CI: 0.87–1.03, p = 0.18). Compared to the bPGAs, however, GL conferred a reduced hazard in each comparison (second IOP medication HR = 0.87, 95% CI: 0.81–0.94, p < 0.001; surgery HR = 0.70, 95% CI: 0.61–0.81, p < 0.001; combined HR = 0.85, 95% CI: 0.79–0.92, p < 0.001). Sensitivity analyses confirmed these findings. Conclusions: GL was no less and possibly more effective in preventing the need for additional intervention than branded PGAs.
Ultra-Low Latency (ULL) Networks: The IEEE TSN and IETF DetNet Standards and Related 5G ULL Research

Many network applications, e.g., industrial control, demand ultra-low latency (ULL). However, traditional packet networks can only reduce the end-to-end latencies to the order of tens of milliseconds. The IEEE 802.1 time sensitive networking (TSN) standard and related research studies have sought to provide link layer support for ULL networking, while the emerging IETF deterministic networking (DetNet) standards seek to provide the complementary network layer ULL support. This paper provides an up-to-date comprehensive survey of the IEEE TSN and IETF DetNet standards and the related research studies. The survey of these standards and research studies is organized according to the main categories of flow concept, flow synchronization, flow management, flow control, and flow integrity. ULL networking mechanisms play a critical role in the emerging fifth generation (5G) network access chain from wireless devices via access, backhaul, and core networks. We survey the studies that specifically target the support of ULL in 5G networks, with the main categories of fronthaul, backhaul, and network management. Throughout, we identify the pitfalls and limitations of the existing standards and research studies. This survey can thus serve as a basis for the development of standards enhancements and future ULL research studies that address the identified pitfalls and limitations.