Miracle-dz/UniFAR-FTUs huggingface dataset:
Exercise in the management of postural orthostatic tachycardia syndrome

Postural Orthostatic Tachycardia Syndrome (POTS) is an autonomic dysfunction characterized by orthostatic symptoms including an increase in heart rate of at least 30 beats per minute (bpm) or reaching above 120 bpm soon after a postural change (Busmer, 2011). Symptoms include, but are not limited to, dizziness, nausea, palpitations, sweating, and fatigue. Twenty-five percent of those with POTS are unable to work (Busmer, 2013). One common pharmacologic treatment is beta-blockers (Lai et al 2009). There is little research into non-pharmacologic treatments, including exercise. The purpose of this case study was to determine if physical activity alleviates physical (heart rate) and psychological (depression and anxiety) symptoms of a patient with POTS. Following eight weeks of physical activity, the patient still met the diagnostic criteria of POTS. However, her quality of life improved based on the WHOQOL-100 AND HADS scores, and she reported being able to perform more tasks at home without feeling heart palpitations. The case study showed an improvement in quality of life for the participant with POTS, but minimal changes in heart rate response following standing post-intervention.
Method of characterizing the interphase’s mean water diffusion properties of a bonded assembly in immersion

ABSTRACT The durability of bonded structures in wet environments is the subject of a large number of studies. The long-term behaviour of these structures is affected and driven by the water diffusion within the adhesive. The literature highlights that the creation of interphases, particular area where chemical and physical bonds are established between the adhesive and the substrate, play an important role in water diffusion kinetics. The aim of this study is to provide amethod to characterize the mean water diffusive properties of the interphases of a bonded assembly in immersion. This approach includes global gravimetric tests of an assembly and an analytical model to characterize its water diffusive parameters. The model divides the bonded joint into two separate layers: one layer representing the adhesive and the other the interfacial area. The water content of each layer can then be estimated using analytical equations. Diffusion parameters are then deduced from these water contents. A greater and faster water diffusion within the interfacial zone has been highlighted. The approach presented here allows to quantify it.
Effects of Salinity and Suspended Solids on Tropical Phytoplankton Mesocosm Communities

Phytoplankton play a fundamental role in marine food webs but are affected by both natural and anthropogenic fluctuations in environmental conditions. Here, to simulate a dynamic coastal environment, we used mesocosms to examine how different salinity levels and suspended solids concentrations (SSCs) impact a natural phytoplankton assemblage collected from a tropical estuary in Singapore. Significant differences in the phytoplankton composition between the baseline and treatments with medium and high SSC were found, but not among the three salinities tested. Differences can be attributed to nutrient limitation (particularly silicate) and the use of kaolinite for the suspended sediment. Silicate limitation is likely to have caused the observed switch in dominant genus from Skeletonema sp. to Chaetoceros sp. and the occurrence of weakly silicified genera such as Cylindrotheca. Kaolinite affected phytoplankton abundance through effects such as shading, flocculation, and nutrient adsorption. These results demonstrated how the combination of various physicochemical effects of suspended solids can influence tropical phytoplankton communities. Furthermore, as suspended solids such as kaolin can be found in the natural environment, this study showed that their potential effects should be evaluated beyond just their concentration.
Information-sharing practices on Facebook during the 2017 French presidential campaign: An “unreliable information bubble” within the extreme right

Abstract This research explores the spread of unreliable information on Facebook during the 2017 French presidential campaign. By analyzing information-sharing behavior on 252 Facebook pages, our study highlights the wide variety of information sources shared by several political communities, notably news published by partisan websites or activist blogs. Our results demonstrate that political parties – particularly, those on the extreme ends of the political spectrum – tend to re-share a large amount of information reflecting the same ideological positions as their own. This trend is amplified by a phenomenon of endo-citation, that is, a “circular circulation” of information between Facebook pages within the same political community. Our results focus on the information practices of the far-right, tracing a clear over-representation of sources that are unreliable or likely to relay disinformation. We argue that this circular transmission of information creates an “unreliable information bubble” that characterizes far-right information-sharing behavior.
A comprehensive pan-cancer study of fibroblast growth factor receptor aberrations in Chinese cancer patients

Background The prevalence and types of fibroblast growth factor receptor (FGFR) mutations vary significantly among different ethnic groups. The optimal application of FGFR inhibitors depends on these variations being comprehensively understood. However, such an analysis has yet to be conducted in Chinese patients. Methods We retrospectively screened the genomic profiling results of 10,582 Chinese cancer patients across 16 cancer types to investigate the frequency and distribution of FGFR aberrations. Results FGFR aberrations were identified in 745 patients, equating to an overall prevalence of 7.0%. A majority of the aberrations occurred on FGFR1 (56.8%), which was followed by FGFR3 (17.7%), FGFR2 (14.4%), and FGFR4 (2.8%). Further, 8.5% of patients had aberrations of more than 1 FGFR gene. The most common types of aberrations were amplification (53.7%), other mutations (38.8%), and fusions (5.6%). FGFR fusion and amplification occurred concurrently in 1.9% of the patients. FGFR aberrations were detected in 12 of the 16 cancers, with the highest prevalence belonging to colorectal cancer (CRC) (31%). Other FGFR-aberrant cancer types included stomach (16.8%), breast (14.3%), and esophageal (12.7%) cancer. Breast tumors were also more likely than other cancer types to have concurrent FGFR rearrangements and amplifications (P<0.001). In comparison with the public dataset, our cohort had a significantly higher number of FGFR aberrations in colorectal (P<0.001) and breast cancer (P=0.05). Conclusions Among the Chinese cancer patients in our study, the overall prevalence of FGFR aberrations was 7.0%. FGFR1 amplification was the most common genetic alteration in CRC, breast cancer, and lung cancer; while FGFR2 amplification was more commonly observed in gastric cancer than in other cancers in our cohort. Our study advances the understanding of the distribution of FGFR aberrations in various cancer types in the Chinese population, which will facilitate the further development of FGFR inhibitors.
Biology and status of aquaculture for giant clams (Tridacnidae) in the Ryukyu Islands, southern Japan

PLEASE SCROLL DOWN TO SEE THE FULL TEXT To cite this document : Iwai, K. , Kiso, K. , & Kubo, H. (2006). Biology and status of aquaculture for giant clams (Tridacnidae) in the Ryukyu Islands, southern Japan. In J. H. Primavera, E. T. Quinitio, & M. R. R. Eguia (Eds.), Proceedings of the Regional Technical Consultation on Stock Enhancement for Threatened Species of International Concern, Iloilo City, Philippines, 13-15 July 2005 (pp. 27-38). Tigbauan, Iloilo, Philippines: Aquaculture Department, Southeast Asian Fisheries Development Center.
Nitrous oxide induced neurotoxicity: a case report and literature review

Nitrous oxide is an increasingly popular recreational drug. However recurrent or prolonged use can be associated with nitrous oxide toxicity, with numerous reports of harm documented in the literature. Nitrous oxide irreversibly binds and inactivates vitamin B12, which is an important co-factor in metabolic pathways involved in DNA and myelin synthesis. Toxicity is therefore associated with vitamin B12 deficiency-related syndromes, primarily involving haematological and neurological systems. As a ‘legal high’, nitrous oxide use has attracted repeated health warnings from experts. An awareness and understanding of the pathophysiology and management of nitrous oxide toxicity is therefore important for clinicians. We discuss the case of a 29-year old man presenting with nitrous oxide-induced sensorimotor neuropathy and review the existing literature surrounding toxicity.
PENERAPAN METODE BERNYANYI DALAM MENINGKATKAN PENGUASAAN KOSA KATA BAHASA ARAB DI MTS MA’ARIF NU 07 PURBOLINGGO

This research aims to determine the application of singing method in improving Arabic vocabulary mastery at MTs Ma'arif NU 07 Purbolinggo. This research is a qualitative research. The subjects in this research were the principal, teachers and students. To obtain the data in this research with the interview as the main method, observation and documentation as a supporting method. Then to analyze the data used descriptive analysis. Analysis of the data used in this research is data reduction, data presentation and conclusion drawing. The results showed that the application of the singing method at MTs Ma'arif NU 07 Purbolinggo could improve students' ability to master vocabulary in Arabic. This can be seen from the memorization of songs where the song lyrics have been replaced with Arabic vocabulary.
Advanced Thermoplastic Composite Manufacturing by In-Situ Consolidation: A Review

This article provides an overview of the evolution of the in-situ consolidation (ISC) process over time. This evolution is intimately linked with the advancements in each of the steps of the ISC manufacturing process, is additive in nature, and is limited by the orthotropic nature of composite materials and the physicochemical behavior of the thermoplastic matrix. This review covers four key topics: (a) Thermal models—simulation tools are critical to understand a process with such large spatial gradients and fast changes. Heating systems once marked a turning point in the development of industrial ISC systems. Today, lasers are the most recent trend, and there are three key issues being studied: The absorption of energy of light by the material, the laser profile, and the laser focusing. Several approaches have been proposed for the distributed temperature measurements, given the strong temperature gradients. (b) Adhesion—this refers to two subsequent mechanisms. In the first place, the process of intimate contact is one by which two surfaces of thermoplastic pre-impregnated composite materials are brought into contact under pressure and temperature. This enables closure of the existing gaps between the two microscopic irregular surfaces. This process is then followed by the healing or diffusion of polymer molecules across the interface. (c) Crystallinity—mostly influenced by the cooling rate, and strongly affects the mechanical properties. (d) Degradation—this refers to the potential irreversible changes in the polymer structure caused by the high temperatures required for the process. Degradation can be avoided through adequate control of the process parameters. The end goal of the ISC manufacturing process is to achieve a high product quality with a high deposition rate through an industrial process competitive with the current manufacturing process for thermoset composites.
What Does Developing a Ranking of Leading Contemporary Art Galleries Unveil about the Importance of the National Factor? An Analysis of Art Basel Art Fair

Since the French sociologist Raymonde Moulin developed her pioneering research in the 1960s, the art market has been continuously studied by social scientists. For several years now, art market studies have rapidly proliferated. Collectors and collections, though, have tended to draw more attention than professionals and dealers, which remain less analyzed. In this article, we intend to study the impact of the national factor on the gallery sector by using a ranking of the leading contemporary art galleries in the world that we ourselves developed. Having analyzed the construction of the most significant rankings in the art world that all focus entirely or partly on artists, we decided to create one for contemporary art galleries. The methodology that we used will be presented in the first part of the article. In its second part, we will analyze the territorial/national dimension that can be identified in the most important art fair in the world, Art Basel. We will comment on what is revealed by our ranking in terms of countries of origin associated with their share and diverse positions in the ranking. Finally, we will address the contribution that our ranking brings to the knowledge of so-called globalization.
Effect of cupping therapy on the level of pain and neuromuscular variables in women with low back pain

Background: Cupping therapy is a common technique in the field of traditional Chinese medicine, which through sucking on the skinmainly results in pain relief. Objectives: To analyze the effect of cupping therapy on pain intensity, muscle co-contraction and trunkextensor muscle strength in women with low back pain. Methods: 26 women participated, divided into: LBPgroup (n = 13), and controlgroup (n = 13). The level of pain, isometric strength of trunk extensor muscles and co-contraction of superficial and deep trunk muscleswere evaluated. The cupping therapy treatment consisted of 10 sessions, and after the volunteers were reevaluated. Anova RepeatedMeasures were used. Results: There was a 40.1% reduction in pain level, a 13.6% increase in trunk extensor strength, and a decreasein contraction between rectus abdominis and iliocostalis for GDL after treatment. Conclusion: 10 sessions of cupping therapy assistin reducing pain and improving trunk strength in young people with lower back pain.
Linking Mesoscale Meteorology With Extreme Landscape Response: Effects of Narrow Cold Frontal Rainbands (NCFR)

Landscapes evolve in response to prolonged and/or intense precipitation resulting from atmospheric processes at various spatial and temporal scales. Whereas synoptic (large‐scale) features (e.g., atmospheric rivers and hurricanes) govern regional‐scale hydrologic hazards such as widespread flooding, mesoscale features such as thunderstorms or squall lines are more likely to trigger localized geomorphic hazards such as landslides. Thus, to better understand relations between hydrometeorological drivers and landscape response, a knowledge of mesoscale meteorology and its impacts is needed. Here we investigate the extreme geomorphic response associated with one type of mesoscale meteorological feature, the narrow cold frontal rainband (NCFR). Resulting from low‐level convergence and shallow convection along a cold front, NCFRs are narrow bands of high‐intensity rainfall that occur in midlatitude areas of the world. Our study examines an NCFR impacting the Sierra Nevada foothills (California, USA) that initiated over 500 landslides, mobilized ~360,000 metric tons of sediment to the fluvial system (as much as 16 times the local annual sediment yield), and severely damaged local infrastructure and regional water transport facilities. Coupling geomorphological field investigations with meteorological analyses, we demonstrate that precipitation associated with the NCFR was both intense (maximum 15 min intensity of 70 mm/hr) and localized, resulting in a highly concentrated band of shallow landsliding. This meteorological phenomenon likely plays an important role in landscape evolution and hazard initiation. Other types of mesoscale meteorological features also occur globally and offer new avenues for understanding the effects of storms on landscapes.
Micro Needle Assisted Drug delivery: A review

Skins pose the barrier to the entry of the foreign particles into the body. However, it is the largest organ of the body. Transdermal drug delivery provides the benefit of the deliver the drug locally and avoids the first pass metabolism. But large drug molecules cannot be delivered by transdermal patches. Microneedles can overcome the skin barrier and deliver drug directly into the blood. Microneedle patches can be detachable or dissolving type and provides the ease of application and use. Thus, potent molecules can be easily administered with greater patient compliance by the transdermal patches.
Purification and characterization of a peptide from soybean with cancer cell proliferation inhibition

A peptide from protein hydrolysate fraction obtained from a high oleic acid soybean line (N98-4445A) that had shown significant activity against human cancer cell lines was identified and purified. Three peptides showing highest activity were identified by reverse phase HPLC in the 10–50 kDa fraction of the protein and purified using peptide specific affinity chromatography column. The three individual peptides were tested for anti-proliferative activity against blood, colon and liver cancer cell lines using 3-(4,5-dimethyl thiazole-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) cell titer assay. Enhanced colon cancer cell inhibition (80%) was observed after testing a pure peptide (molecular size of 18 kDa with 158 amino acid residues) which also demonstrated a time-response of 96 hr after incubation based on trypan blue dye exclusion study. The impact of this study lies in deriving a pure single peptide with anti-proliferative activity on human colon and blood cancer cells. Practical applications Soybean is cultivated in the United States mostly for extracting the oil leaving the residue (soybean meal) which is commonly used as an animal feed due to its high protein content. This study has shown that soy peptides produced enzymatically from the meal of a high oleic acid soybean line (N98-4445A) were found to have anticancer activity. This study demonstrated an impending value for a pure peptide derived from this soy peptides as an alternative and inexpensive anti-cancer therapeutic agent as well as a value addition to soy meal by-product.
Determinants of illegal logging in Indonesia: An empirical analysis for the period 1996–2010

ABSTRACT Illegal logging is a significant problem in Indonesia, which is one of the few countries with a large forest area. In this study, we investigate the factors that affect harvesting and supply of illegal timber from Indonesia to China and Japan. Moreover, we investigate the factors that lead to the demand of Indonesian illegal timber from China and Japan. A simultaneous-equation econometric model of illegally logged timber demand and supply is developed and tested using the annual data over the period 1996–2010. We find that corruption and decentralization in Indonesia have significant and positive impacts on the illegally logged timber supply while excess demand in Japanese construction and furniture industries as well as Japan’s housing starts are the significant factors that affect the illegal logging in Indonesia. The law enforcement or policies aimed at reducing illegal harvesting in Indonesia are found to be more effective than the policies targeting the import of illegally logged timber into Japan and China.
Genetic diversity and molecular characterization of natural Pancratium maritimum L. populations by DNA markers

Bulbous plants play an important role in Turkey's biodiversity due to their great potential use in various industries. Sea daffodils (Pancratium maritimum), one aspect of Turkey's biological richness, represent an important bulbous plant that generally spreads on sand dunes and can be seen only on the Mediterranean coast and on its certain beaches in our country. In this study, the genetic structure and genetic diversity of four natural P. maritimum populations have been determined by RAPD and nrSSR primers. Eight RAPD and four nrSSR loci were analyzed. All RAPD and nrSSR loci, except SSR-20, were found to be polymorphic. Genetic diversity parameters such as mean number of alleles for each nrSSR loci (Na = 3.313), effective allele number (Ne = 2.190), Shannon's information index (I = 0.728), observed heterozygosity (Ho = 0.449) and expected heterozygosity (He = 0.396) were calculated. A rather high proportion of the genetic diversity (81% for nrSSR, 72% for RAPD) was due to within-population variation and the remaining part was due to variation between populations. According to the acquired UPGMA phenogram for RAPD and nrSSR data, the Igneada and Camlikoy populations, which are geographically close, are also genetically the most similar populations. The STRUCTURE analysis results supported the constructed UPGMA phenogram for the studied sea daffodil populations. The results of this study include important information about the genetic structure of the studied populations.
PGC-1β prevents statin-associated myotoxicity in oxidative skeletal muscle

Statins are generally well-tolerated, but can induce myopathy. Statins are associated with impaired expression of PGC-1β in human and rat skeletal muscle. The current study was performed to investigate the relation between PGC-1β expression and function and statin-associated myopathy. In WT mice, atorvastatin impaired mitochondrial function in glycolytic, but not in oxidative muscle. In PGC-1β KO mice, atorvastatin induced a shift from oxidative type IIA to glycolytic type IIB myofibers mainly in oxidative muscle and mitochondrial dysfunction was observed in both muscle types. In glycolytic muscle of WT and KO mice and in oxidative muscle of KO mice, atorvastatin suppressed mitochondrial proliferation and oxidative defense, leading to apoptosis. In contrast, mitochondrial function was maintained or improved and apoptosis decreased by atorvastatin in oxidative muscle of WT mice. In conclusion, PGC-1β has an important role in preventing damage to oxidative muscle in the presence of a mitochondrial toxicant such as atorvastatin.
Analysis and Prospects of International E-learning Research Hotspots

Using the Web of Science database as a literature source and Citespace to analyze the 592 selected literatures, first of all, we find that Spain has become one of the most influential countries in the field of E-learning. Then, by clustering analysis, we find that the main research hotspots in E-learning are Universal Design for Learning, Teacher Training, Technology Acceptance Model and Ubiquitous Learning. We also analyze the representative research themes in the field of E-learning. The future picture of E-learning is envisioned, namely, integration of inclusion and personalization, acceptance of diversity and complexity, reaffirmation of humanity and equity and moving towards AI and ubiquity.