Miracle-dz/UniFAR-FTUs huggingface dataset:
Nanotechnology development status in Malaysia: industrialization strategy and practices

Malaysia has started it own micro-technology and nano-technology development since the early millennium year of 2000 and arise until this day. Some key plans have proven effective and others fairly not. Status about strategies and practices planned in Malaysia with some relevant finding through experiences in industries collaboration observations and UniMAP involvement in nanotechnology are presented in this paper. Some suggestion and ideas are also presented.
N-Linked Glycans with Similar Location in the Fusion Protein Head Modulate Paramyxovirus Fusion

ABSTRACT N-linked glycans not only orchestrate the folding and intracellular transport of viral glycoproteins but also modulate their function. We have characterized the three glycans attached to fusion (F) proteins of the morbilliviruses canine distemper virus and measles virus. The individual Morbillivirus glycans have similar functional properties: the glycan at position 68 is essential for protein transport, and those at positions 36 and 75 modulate fusion (numbering according to the Newcastle disease virus [NDV] F protein sequence). Based on the crystal structure of the NDV F protein, we then predicted the locations of the Morbillivirus glycans: the glycan at position 36 is located in the F protein head, and those at positions 68 and 75 are located near the neck-stalk interface. NDV position 36 is not occupied by a glycan; the only glycan in that F protein head also has a fusion control function and grows from residue 366, located only 6 Å from residue 36. We then exchanged the glycan at position 36 with the glycan at position 366 and showed functional complementation. Thus, structural information about the F proteins of Paramyxoviridae coupled with functional analysis disclosed a location in the protein head into which fusion-modulating glycans independently evolved.
Multiple sclerosis: can Schwann cells wrap it up?

Multiple Sclerosis (MS) is a common, heterogeneous disorder of the central nervous system (CNS). Its causes and the factors that contribute to its heterogeneity are largely unknown. The disease affects about 0.1 percent of the population in temperate climates (approximately 1.4 million people worldwide) [1]. It is a disease of young people (median age of onset is approximately 28 years) but is lifelong and is often disabling In multiple sclerosis, the immune system attacks the brain's nerve fibers and strips away the protective myelin sheath around nerve fibers in the spinal cord and brain. The resulting lesions make it difficult for the nerves to transmit messages. The cause of MS is not known. Epidemiological findings support both environmental and genetic hypotheses, and these forces likely interact to produce individual disease susceptibility and influence disease course. CELL REPLACEMENT AS A SOLUTION TO MS
Efficient Computation of Hessian Matrices in a Monte Carlo Setting using Automatic Differentiation

The evaluation of differentiable functions often requires computation of the first and second derivatives. Automatic differentiation is a good method to compute the derivatives, but it can be costly to compute the Hessian when involving large number of variables. In this paper, we develop a new structured AD technique which is applicable when the objective function is in structured form, such as in a Monte Carlo setting. Both the theory and experimental results show that our new structured AD has a very high efficiency in computational space utilization for the Hessian evaluation.
Transcription factor ATF2 regulation by the JNK signal transduction pathway

Treatment of cells with pro-inflammatory cytokines or ultraviolet radiation causes activation of the c-Jun NH2-terminal protein kinase (JNK). Activating transcription factor-2 (ATF2) was found to be a target of the JNK signal transduction pathway. ATF2 was phosphorylated by JNK on two closely spaced threonine residues within the NH2-terminal activation domain. The replacement of these phosphorylation sites with alanine inhibited the transcriptional activity of ATF2. These mutations also inhibited ATF2-stimulated gene expression mediated by the retinoblastoma (Rb) tumor suppressor and the adenovirus early region 1A (E1A) oncoprotein. Furthermore, expression of dominant-negative JNK inhibited ATF2 transcriptional activity. Together, these data demonstrate a role for the JNK signal transduction pathway in transcriptional responses mediated by ATF2.
A Web Based Tool for an Automated Dental Identification System (ADIS)

We present a web-based environment for the Automated Dental Identification System (ADIS). This system is designed for identification missing, unidentified and wanted persons based on dental characteristics. The web-based environment of ADIS allows users to browse through different databases from remote locations, to digitally process query dental images in order to extract the distinctive features used for record matching, and to finally present to the forensic expert a short match list to be inspected.
Positioning of toleranced parts in a 2D polygonal assembly and its use in tolerance analysis

The paper analyzes the mating natures of a 2D polygonal assembly and discusses uncertainty in assemblies due to the geometric (size and shape) variations of the assembled parts. To study variant assembly configurations, translational and rotational motion constraints are generated by analyzing geometric contact relations between variant parts. Based on these motion constraints, the uncertainty build-ups in an assembly of toleranced parts are investigated.
Identification by Full-Genome Analysis of a Bovine Rotavirus Transmitted Directly to and Causing Diarrhea in a Human Child

ABSTRACT The genome of rotaviruses consists of 11 segments of double-stranded RNA, and each genome segment has multiple genotypes. Thus, the genotype constellation of an isolate is often indicative of its host species. Albeit rarely, interspecies transmission occurs either by virions with nonreassorted or reassorted genomic segments. A rotavirus with the G6P[1] genotype, Ro8059, was isolated from the stool of a 1-year-old child during routine characterization of diarrheal specimens from a sentinel clinic in Israel in 1995. Since genotype G6P[1] is generally associated with bovine rotaviruses, and the child developed diarrhea within days of his first contact with calves at an urban farm, the aim of this study was to characterize the whole genomic constellation of Ro8059 and four G6P[1] bovine strains, BRV101, BRV105, BRV106, and CR231/39, by RNA-RNA hybridization and full genome sequencing to determine whether some or all of the segments were of bovine origin. The genome constellations of all four bovine G6P[1] strains were G6-P[1]-I2-R2-C2-M2-A3-N2-T6-E2-H3 for VP7-VP4-VP6-VP1-VP2-VP3-NSP1-NSP2-NSP3-NSP4-NSP5, respectively. Ro8059 shared the same genotype constellation with these bovine strains, with high nucleotide sequence identities (95.84 to 100%) for each of the 11 segments indicating that Ro8059 represented a direct interspecies whole-genome transmission of a nonreassorted rotavirus from a calf to a human infant. We conclude that this was the earliest example with a complete epidemiological link in which an entirely bovine rotavirus directly infected a human child and caused a symptomatic diarrheal illness. Thus, not all bovine rotaviruses are always naturally attenuated to the human host.
Domain organization of the MscS mechanosensitive channel of Escherichia coli

The major structural features of the Escherichia coli MscS mechanosensitive channel protein have been explored using alkaline phosphatase (PhoA) fusions, precise deletions and site‐directed mutations. PhoA protein fusion data, combined with the positive‐inside rule, strongly support a model in which MscS crosses the membrane three times, adopting an Nout–Cin configuration. Deletion data suggest that the C‐terminal domain of the protein is essential for the stability of the MscS channel, whereas the protein will tolerate small deletions at the N‐terminus. Four mutants that exhibit either gain‐of‐function (GOF) or loss‐of‐function have been identified: a double mutation I48D/S49P inactivates MscS, whereas the MscS mutants T93R, A102P and L109S cause a strong GOF phenotype. The similarity of MscS to the last two domains of MscK (formerly KefA) is reinforced by the demonstration that expression of a truncated MscK protein can substitute for MscL and MscS in downshock survival assays. The data derived from studies of the organization, conservation and the influence of mutations provide significant insights into the structure of the MscS channel.
Traffic quality monitoring system between different network providers

In this paper, we propose a network performance monitoring method which can measure delay of each network using the RTCP(Real-time Transport Control Protocol) timestamp fields to detect a trouble section in interworking environment. According to the increment of real-time multimedia service provision, network performance monitoring method is necessarily needed for QoS management of real-time services in the interworking environment between different networks. Multimedia services such as video conference, VoIP (Voice over IP) service and IPTV service are sensitive to the network performance(e.g. delay, delay variance and packet loss etc). In this case, it is very important to detect a trouble section when service quality degradation occurs in the interworking environment. So, we propose the network monitoring method for multimedia services through delay measurement using RTCP in each network. Also, with this method, we can detect and define which network has generated a poor network performance.
Targeting the MEF 2-Like Transcription Factor Smp 1 by the Stress-Activated Hog 1 Mitogen-Activated Protein Kinase

Exposure of Saccharomyces cerevisiae to increases in extracellular osmolarity activates the stress-activated Hog1 mitogen-activated protein kinase (MAPK), which is essential for cell survival upon osmotic stress. Yeast cells respond to osmotic stress by inducing the expression of a very large number of genes, and the Hog1 MAPK plays a critical role in gene transcription upon stress. To understand how Hog1 controls gene expression, we designed a genetic screen to isolate new transcription factors under the control of the MAPK and identified the MEF2-like transcription factor, Smp1, as a target for Hog1. Overexpression of SMP1 induced Hog1-dependent expression of osmoresponsive genes such as STL1, whereas smp1 cells were defective in their expression. Consistently, smp1 cells displayed reduced viability upon osmotic shock. In vivo coprecipitation and phosphorylation studies showed that Smp1 and Hog1 interact and that Smp1 is phosphorylated upon osmotic stress in a Hog1-dependent manner. Hog1 phosphorylated Smp1 in vitro at the C-terminal region. Phosphorylation of Smp1 by the MAPK is essential for its function, since a mutant allele unable to be phosphorylated by the MAPK displays impaired stress responses. Thus, our data indicate that Smp1 acts downstream of Hog1, controlling a subset of the responses induced by the MAPK. Moreover, Smp1 concentrates in the nucleus during the stationary phase, and the lack of SMP1 results in cells that lose viability in the stationary phase. Localization of Smp1 depends on HOG1, and consistently, hog1 cells also lose viability during this growth phase. These data suggest that Smp1 could be mediating a role for the Hog1 MAPK during the stationary phase.
Transferring auxiliary knowledge to enhance heterogeneous web service clustering

The growing number of web services puts forward higher requirements for searching desired web services, and clustering web services can greatly enhance the discovery of web service. Most existing clustering approaches are designed to handle long text documents. However, the descriptions of most services are in the form of short text, which impairs the quality of clustering owing to the lack of statistical information. To solve this problem, we propose a new service clustering approach based on transfer learning from auxiliary long text data obtained from Wikipedia. To handle the inconsistencies in semantics between service descriptions and auxiliary data, we introduce a novel topic model - dual tag aided latent Dirichlet allocation DT-LDA, which jointly learns two sets of topics on the two datasets. Experimental results show the proposed approach achieves better performance than several existing approaches.
The difference between activity when in bed and out of bed. II. Subjects on 27-hour "days".

Nine healthy subjects have been studied while exposed to the normal alternation of light and dark, but with their sleep and activity pattern adjusted to a 27-h "day" for 17 imposed "days. " Rectal temperature showed clearly the competing influences of 27-h and 24-h components, and these were separated by the method of "purification. " The method indicated that the endogenous component had a constant amplitude throughout the experiment and remained entrained to solar (24-h) time; by contrast, the exogenous component followed the imposed 27-h "day" and increased rectal temperature in proportion to the amount of subjects' activity. Wrist movement was used to assess activity while in bed (attempting sleep) and out of bed (when naps were forbidden). While these results confirmed adherence of the subjects to the imposed 27-h "days," they also showed that the dichotomy between "out of bed" activity and "in bed" inactivity depended on the phase relationship between endogenous (24h) and exogenous (27h) components. Thus, the dichotomy was highest and was equal to that during control days (with a conventional 24-h life-style) when the two components were in phase and lowest when the solar and imposed day were in antiphase. This was due to changes in activity, both during time spent in bed and out of bed. We confirm that this protocol can produce valuable information about the properties of the circadian system in humans and the value of the process of purification of temperature data. We have established also that the very simple and noninvasive measurement of wrist movement, coupled with its use to calculate dichotomy indices, provides valuable information that both confirms and extends the results obtained from the more conventional (but also more invasive) measurement of rectal temperature.
Patient-rated versus clinician-rated side effects of drug treatment in schizophrenia. Clinical validation of a self-rating version of the UKU Side Effect Rating Scale (UKU-SERS-Pat)

A self-rating version of the UKU Side Effect Rating Scale has been developed. The present study examines the agreement between patients' self-assessment of side effects and the attending clinicians' ratings. The patient sample consisted of 63 patients with schizophrenia under maintenance treatment with risperidone, clozapine or classical antipsychotics. Approximately two thirds of the patients used concomitant medication with e.g. benzodiazepines, SSRIs, anticholinergics. Most inter-correlations between scores for single, corresponding items, subscores of Psychic, Neurological, Autonomic and Other side effects, as well as the Total Score from the patient version of the UKU Side Effect Self Rating Scale (UKU-SERS-Pat) and the clinician version (UKU-SERS-Clin) were found to be statistically significant. Patients reported side effects more frequently and/or rated symptoms more severe than the clinicians. The results support the validity of the SERS-Pat and suggest that patient rated side effects may provide important clinical information not detected by clinician rated interviews. Such information can be utilised both in clinical investigations, in development of treatment programs and for individual patients in clinical practice.
Diffeomorphic Density Matching by Optimal Information Transport

We address the following problem: given two smooth densities on a manifold, find an optimal diffeomorphism that transforms one density into the other. Our framework builds on connections between the Fisher–Rao information metric on the space of probability densities and right-invariant metrics on the infinite-dimensional manifold of diffeomorphisms. This optimal information transport, and modifications thereof, allow us to construct numerical algorithms for density matching. The algorithms are inherently more efficient than those based on optimal mass transport or diffeomorphic registration. Our methods have applications in medical image registration, texture mapping, image morphing, nonuniform random sampling, and mesh adaptivity. Some of these applications are illustrated in examples.
DELINEATION OF CHOROIDAL AND RETINAL LESIONS IN POSTERIOR UVEITIS BY MULTISPECTRAL WIDE-FIELD SCANNING LASER OPHTHALMOSCOPY

Purpose: To investigate whether wide-field multispectral scanning laser ophthalmoscopy could assist in determining depth of chorioretinal pathology in posterior uveitis. Methods: Cross-sectional retrospective review of patients with birdshot chorioretinopathy (BCR; 42 eyes of 21 patients) or active primary vitreoretinal lymphoma (PVRL; 18 eyes of 10 patients) who had multispectral wide-field scanning laser ophthalmoscopy (Optos) images. Images acquired with 532 nm and 635 nm lasers were analyzed separately using Optos V2 Vantage Pro Review software. Results: All 42 eyes with birdshot chorioretinopathy and 8/18 eyes with active primary vitreoretinal lymphoma had lesions on 635 nm imaging, while 26/42 of the birdshot chorioretinopathy eyes and 18/18 eyes with active primary vitreoretinal lymphoma had lesions on 532 nm imaging. The difference between the 2 groups on both 635 nm and 532 nm was statistically significant (P < 0.05). Conclusion: Retinal and choroidal lesions in patients with posterior uveitis can be differentially visualized with Optos 532 nm and 635 nm lasers, respectively, allowing determination of depth of pathology.
Monitoring and Discussing Health Related Quality of Life in adolescents with type 1 diabetes improves psychosocial well-being . A randomized controlled trial

1. Department of Medical Psychology, VU University Medical Center Amsterdam, The Netherlands 2. EMGO Institute, VU University Medical Center Amsterdam, The Netherlands 3. Department of Pediatrics, VU University Medical Center Amsterdam, The Netherlands 4. Institute of Clinical and Experimental Neurosciences, VU University Medical Center Amsterdam, The Netherlands 5. Department of Pediatrics, Spaarne Ziekenhuis Hoofddorp, The Netherlands 6. Department of Pediatrics, Medical Center Alkmaar, The Netherlands 7. Department of Pediatrics, Juliana Kinderziekenhuis Den Haag, The Netherlands
Organizing Information for Execution Time Analysis in Real-Time Embedded Systems

Response-time constraint is the most important property in real-time systems. Therefore, timing prediction for the guarantee of response-time is requisite for real-time software development. Real-time software is composed of a number of timeand event-triggered methods. As the relationship of different methods caused by time definitions, the execution time analysis of software for timing prediction is generally extremely difficult. As such, this paper presents a program segment for a unit of automation analysis that divides control flows by behaviors of time and events. This program segment is the result of dividing complex programs into simple intuitive codes. The proposed program segment simplifies the analysis target, reduces the overhead due to duplicate analysis and yields formal execution time analysis methods. It can be used to either a static or dynamic execution time analysis by infrastructure. Therefore, developers can easily verify temporal correctness, and understand the timing relationship of software.
Genetic evidence for a product of the Fv-1 locus that transfers resistance to mouse leukemia viruses

Extracts of mouse cells have been shown to transfer to N- or B-trophic host range types of mouse leukemia viruses. The genetic specificity of the inhibition was tested in two ways: (i) by correlating the Fv-1 genotype of a number of mouse strains with the restriction-transferring activity of extracts of the respective embryo cell cultures, and (ii) by correlating the Fv-1 genotype of BLC3F2 (C57BL/6 female [Fv-1bb] by C3H male [Fv-1nn] parental strains) mouse embryos, which segregate the Fv-1 alleles in a 12:1 ratio, with the inhibitor activity of extracts of the cells from each embryo. Five independent matings, totaling 45 individual embryos, were tested. Each embryo was cultured, and the Fv-1 genotype was determined independently by titration of N- and B-tropic viruses; the extracts of replicate secondary cultures were tested for their effect on infection of permissive cells by N- and B-tropic viruses. The specific-restriction-transferring activity of the embryos was found to segregate with the appropriate Fv-1 genotype. These res-lts confirm the suggestion that the inhibitor of the leukemia virus host range types in the cellular extracts is a product of the Fv-1 locus.
Design of a contactless battery charging system

Inductive contactless energy transfer systems (CETS) transfer electric energy between their input and output section without any wired connection. The coupling device consists of two coils whose setup is a crucial issue in building up a CETS. This paper presents the design procedure of the coils of a CETS intended to charge the battery pack of electric city car. The procedure encompasses the determination of the inductive parameters of the coils when ferrite cores with different geometries are considered. Topology and sizing of the power inverter supplying the transmitter coils are also addressed. The results of the numerical analysis are validated by the outcomes of finite element method and power circuit simulation simulations.
Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells

Abstract Cathepsins are implicated in a multitude of physiological and pathophysiological processes. The aim of the present study was to investigate the function of cathepsin L (catL) in the proteolytic network of human lung epithelial cells and its role in the regulation of apoptosis. We found that catL-deficient A549 cells as well as lung tissue extracts of catL[-/-] mice express increased amounts of single-chain cathepsin D (catD). Degradation experiments indicate that catL specifically degrades the singlechain isoform of catD. Furthermore, we found that catLdeficient cells showed increased sensitivity to apoptosis. Finally, we demonstrate that the inhibition of catD activity by pepstatin A decreased the number of apoptotic cells in catLdeficient A549 cells after anti-Fas treatment. In conclusion, catL is involved in catD processing and the accumulation of catD isoforms in catL-deficient cells is associated with increased rates of spontaneous and anti-Fas-induced apoptosis.