Miracle-dz/UniFAR-FTUs huggingface dataset:
THE COMPOSITION OF THE FIRMS’ INDEBTEDNESS AND THE MACROECONOMY OF CAPITAL: AN ECONOMIC ANALYSIS BUILT THROUGH ACCOUNTING INFORMATION

The objective of this research is to analyze the influence that monetary policies exert on the composition of the indebtedness of Brazilian corporations. From this objective, 2 hypotheses derive. The first analyzes the sample aggregate and the second directs the tests to the productive sectors. The study sample is composed of 220 companies: 84 of consumer goods, 89 of capital goods and 47 of public utility. The data collected refer to the years 2009 to 2019. The methodology used for data analysis is through panel data models, using the GMM approach. According to the results, it can be concluded - in the light of the macroeconomics of capital - that the composition of the firms' indebtedness can be determined by the market moments defined by the monetary policies, so that such influence is different depending on the sector to which the companies are located in the production chain. These results complement the literature that studies the impacts of monetary policies and macroeconomic variables on corporate finance, mainly through econometric modeling based on accounting data.
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How can we orchestrate an one-off sharing of informative data about individuals, while bounding the risk of disclosing sensitive information to an adversary who has access to the global distribution of such information and to personal identifiers? Despite intensive efforts, current privacy protection techniques fall short of this objective. Differential privacy provides strong guarantees regarding the privacy risk incurred by one’s participation in the data at the cost of high information loss and is vulnerable to learning-based attacks exploiting correlations among data. Syntactic anonymization bounds the risk on specific sensitive information incurred by data publication, yet typically resorts to a superfluous clustering of individuals into groups that forfeits data utility. In this paper, we develop algorithms for disclosure control that abide to sensitive-information-oriented syntactic privacy guarantees and gain up to 77% in utility against current meth-ods. We achieve this feat by recasting data heterogeneously , via bipartite matching, rather than homogeneously via clustering. We show that our methods resist adversaries who know the employed algorithm and its parameters. Our experimental study featuring synthetic and real data, as well as real learning and data analysis tasks, shows that these methods enhance data utility with a runtime overhead that is small and reducible by data partitioning,while the 𝛽 -likeness guarantee with heterogeneous generalization staunchly resists machine-learning-based attacks, hence offers practical value.
Bethe Ansatz Equations of XXZ Model and q-Sturm-Liouville Problems

In this article we have discovered a close relationship between the (algebraic) Bethe Ansatz equations of the spin $s$ XXZ model of a finite size and the $q$-Sturm-Liouville problem. We have demonstrated that solutions of the Bethe Ansatz equations give rise to the polynomial solutions of a second order $q$-difference equation in terms of Askey-Wilson operator. The more general form of Bethe Ansatz equations and the mathematical problems relevant to the physics of XXZ model are discussed. Furthermore, the similar correspondence between Bethe Ansatz equations of XXX model and the Sturm-Liouville type difference equation in terms of Wilson operator has also been found.
The magnetic field configurations of AM Herculis binaries

We have considered equilibrium configurations of a white dwarf and a red dwarf companion in AM Herculis type binary system where the red dwarf is assumed to have an intrinsic centered dipole field, and the white dwarf an offset dipole or a centered dipole plus a quadrupole field, and the interaction is purely magnetic. The restoring torque, due to the system being perturbed from its stable equilibrium configuration, is compared with the accretion torque. The results are used to show that the observed alignment of the main cyclotron emission region relative to the red star can be explained quite simply by these models without having to invoke gravitational torques. We also provide a possible explanation of the observation that the more strongly accreting pole has the weaker field strength in the few systems where fields have been determined at both poles.
First results of the CROME experiment

It is expected that a radio signal in the microwave range is produced in the atmosphere due to molecular bremsstrahlung initiated by extensive air showers. The CROME (Cosmic-Ray Observation via Microwave Emission) experiment was built to search for this microwave signal. Radiation from the atmosphere is monitored in the extended C band (3.4--4.2 GHz) in coincidence with showers detected by the KASCADE-Grande experiment. The detector setup consists of several parabolic antennas and fast read-out electronics. The sensitivity of the detector has been measured with different methods. First results after half a year of data taking are presented.
Neural network for classification waters sample of shatt al Arabe River

In this study, we develop an automated system that uses a collection of attributes to classify water samples from the Shatt al Arabe River (EC, Cl, Ca, Mg, Na, and SO4). There are three steps to the water categorization system: First and foremost, in this manner From October 2009 to September 2020, water samples were taken monthly from eight locations along the Shatt Al-Arab River in Basra. Qurna, Tubular Bridge, Al Muzairah (station 1), Saad Birdge (station 2), Al-Karma (station 3), Al-Sandbad (station 4), Al-Ashar (station 5), Abo Al-Kasseb (station 6), Al-Seba (station 7) and Al-Foa (station 8) are among these locations (station 8). Second, using established procedures, measured and analyzed chemical elements such as electrical conductivity (Ec), chloride (CL), calcium (Ca), magnesium (Mg), sodium (Na), and Sulphate (SO4). Finally, there are neural networks with three hidden layers are used for training and testing purposes. The experimental results on the collected database show that the proposed approach achieves high accuracy in automatic water classification (normal and abnormal). The Project is designed by Matlab.
The key clock component ZEITLUPE (ZTL) negatively regulates ABA signaling by degradation of CHLH in Arabidopsis

Ubiquitination-mediated protein degradation plays important roles in ABA signal transduction and delivering responses to chloroplast stress signals in plants, but additional E3 ligases of protein ubiquitination remain to be identified to understand the complex signaling network. Here we reported that ZEITLUPE (ZTL), an F-box protein, negatively regulates abscisic acid (ABA) signaling during ABA-inhibited early seedling growth and ABA-induced stomatal closure in Arabidopsis thaliana. Using molecular biology and biochemistry approaches, we demonstrated that ZTL interacts with and ubiquitinates its substrate, CHLH/ABAR (Mg-chelatase H subunit/putative ABA receptor), to modulate CHLH stability via the 26S proteasome pathway. CHLH acts genetically downstream of ZTL in ABA and drought stress signaling. Interestingly, ABA conversely induces ZTL phosphorylation, and high levels of ABA also induce CHLH proteasomal degradation, implying that phosphorylated ZTL protein may enhance the affinity to CHLH, leading to the increased degradation of CHLH after ABA treatment. Taken together, our results revealed a possible mechanism of reciprocal regulation between ABA signaling and the circadian clock, which is thought to be essential for plant fitness and survival.
Control Efficacy and Deposition Characteristics of an Unmanned Aerial Spray System Low-Volume Application on Corn Fall Armyworm Spodoptera frugiperda

As a major global pest, fall armyworm (FAW), Spodoptera frugiperda, invaded China in 2019, which has seriously threatened the safety of China's food production and raised widespread concerns. As a new low-volume application technology, an unmanned aerial spray system (UASS) is playing an important role in the control of FAW in China. However, the studies on the effect of the water application volume on the efficacy of FAW using UASS have been limited. In this study, Kromekote® cards were used to sample the deposition. The method of using a sampling pole and sampling leaf for the determination of deposition. Four water application volumes (7.5, 15.0, 22.5, and 30.0 L/ha) were evaluated with regard to the corn FAW control efficacy. A blank control was used as a comparison. The control efficacy was assessed at 1, 3, 7, and 14 days after treatment (DAT). The tested results showed that sampling methods have a significant effect on deposition results. The number of spray deposits and coverage on the sampling pole were 35 and 40% higher than those on the sampling leaves, respectively. The deposition and control efficacy gradually increased as the water application volume increased. The control efficacy at 14 DAT under different water application volumes was in the range of 59.4–85.4%. These data suggest that UASS spraying can be used to achieve a satisfying control of FAW, but the control efficacy of the water application volume of 30.0 and 22.5 L/ha did not differ significantly. Considering work efficiency, a water application volume of 22.5 L/ha is recommended for field operation.
Dietary mannan oligosaccharides strengthens intestinal immune barrier function via multipath cooperation during Aeromonas Hydrophila infection in grass carp (Ctenopharyngodon Idella)

In recent years, mannose oligosaccharide (MOS) as a functional additive is widely used in aquaculture, to enhance fish immunity. An evaluation of the effect of dietary MOS supplementation on the immune barrier function and related signaling molecules mechanism of grass carp (Ctenopharyngodon idella) was undertaken in the present study. Six diets with graded amounts of MOS supplementation (0, 200, 400, 600, 800, and 1000 mg/kg) were fed to 540 grass carp over 60 days. To examine the immune response and potential mechanisms of MOS supplementation on the intestine, a challenge test was conducted using injections of Aeromonas hydrophila for 14 days. Results of the study on the optimal supplementation with MOS were found as follows (1) MOS enhances immunity partly related to increasing antibacterial substances content and antimicrobial peptides expression; (2) MOS attenuates inflammatory response partly related to regulating the dynamic balance of intestinal inflammatory cytokines; (3) MOS regulates immune barrier function may partly be related to modulating TLRs/MyD88/NFκB and TOR/S6K1/4EBP signalling pathways. Finally, the current study concluded that MOS supplementation could improve fish intestinal immune barrier function under Aeromonas hydrophila infected conditions.
First in vivo analysis of the regulatory protein CP12 of the model cyanobacterium Synechocystis PCC 6803: Biotechnological implications

We report the first in vivo analysis of a canonical CP12 regulatory protein, namely the unique CP12 of the model cyanobacterium Synechocystis PCC 6803, which has the advantage of being able to grow photoautotrophically, photomixotrophically, and photoheterotrophically. The data showed that CP12 is dispensable to cell growth under standard (continuous) light and light/dark cycle, whereas it is essential for the catabolism of exogenously added glucose that normally sustains cell growth in absence of photosynthesis. Furthermore, to be active in glucose catabolism, CP12 requires its three conserved features: its AWD_VEEL motif and its two pairs of cysteine residues. Also interestingly, CP12 was found to regulate the redox equilibrium of NADPH, an activity involving its AWD_VEEL motif and its C-ter cysteine residues, but not its N-ter cysteine residues. This finding is important because NADPH powers up the methylerythritol 4-phosphate (MEP) pathway that synthesizes the geranyl-diphosphate (GPP) and farnesyl-diphosphate (FPP) metabolites, which can be transformed into high-value terpenes by recombinant cyanobacteria producing plant terpene synthase enzymes. Therefore, we have introduced into the Δcp12 mutant and the wild-type (control) strain our replicative plasmids directing the production of the monoterpene limonene and the sesquiterpene bisabolene. The photosynthetic production of both bisabolene and limonene appeared to be increased (more than two-fold) in the Δcp12 mutant as compared to the WT strain. Furthermore, the level of bisabolene production was also higher to those previously reported for various strains of Synechocystis PCC 6803 growing under standard (non-optimized) photoautotrophic conditions. Hence, the presently described Δcp12 strain with a healthy photoautotrophic growth and an increased capability to produce terpenes, is an attractive cell chassis for further gene manipulations aiming at engineering cyanobacteria for high-level photoproduction of terpenes.
Construction of a focal adhesion signaling pathway-related ceRNA network in pelvic organ prolapse by transcriptome analysis

Objective: Pelvic organ prolapse (POP) affects a large proportion of adult women, but the pathogenesis of POP remains unclear. The increase in global population aging will impose a substantial medical burden. Herein, we aimed to explore the related RNAs regulating the occurrence of POP and provide potential therapeutic targets. Method: Tissue biopsies were collected from the anterior vaginal wall of six women with POP and six matched subjects without POP. The profiles of mRNAs, circRNAs, lncRNAs, and miRNAs were obtained by whole transcriptome RNA sequencing. Result: The findings revealed that 71 circRNAs, 76 known lncRNAs, 84 miRNAs, and 931 mRNAs were significantly altered (p < 0.05 and |log2FC| > 1). GO and KEGG enrichment analyses indicated that the differentially expressed genes (DEGs) were mainly enriched in the focal adhesion signaling pathway. FLT, ITGA9, VEGFD, PPP1R12B, and ROCK2 were identified as focal adhesion signaling pathway-related hub genes by protein–protein interaction network analysis. Based on the relationships between the DEGs and miRNA, lncRNA and circRNA targets, we constructed a focal adhesion signaling pathway-related ceRNA network. The ceRNA network includes hsa_circ_0002190/hsa_circ_0046843/lnc-CARMN -miR-23a-3p - ROCK2 and hsa_circ_0001326/hsa_circ_0007733/lnc-AC107959/lnc-TPM1-AS - miR-205-5p - ROCK2/PPP1R12B/VEGFD. Moreover, abnormalities in the cytoskeleton in fibroblasts from individuals with POP were observed. Conclusion: In this study, a focal adhesion signaling pathway-related ceRNA network was constructed, and this network may serve as a target for finding suitable drugs for the treatment of POP.
Selective transduction of cerebellar Purkinje and granule neurons using delivery of AAV-PHP.eB and AAVrh10 vectors at axonal terminal locations

Adeno-associated virus (AAV)-based brain gene therapies require precision without off-targeting of unaffected neurons to avoid side effects. The cerebellum and its cell populations, including granule and Purkinje cells, are vulnerable to neurodegeneration; hence, conditions to deliver the therapy to specific cell populations selectively remain challenging. We have investigated a system consisting of the AAV serotypes, targeted injections, and transduction modes (direct or retrograde) for targeted delivery of AAV to cerebellar cell populations. We selected the AAV-PHP.eB and AAVrh10 serotypes valued for their retrograde features, and we thoroughly examined their cerebellar transduction pattern when injected into lobules and deep cerebellar nuclei. We found that AAVrh10 is suitable for the transduction of neurons in the mode highly dependent on placing the virus at axonal terminals. The strategy secures selective transduction for granule cells. The AAV-PHP.eB can transduce Purkinje cells and is very selective for the cell type when injected into the DCN at axonal PC terminals. Therefore, both serotypes can be used in a retrograde mode for selective transduction of major neuronal types in the cerebellum. Moreover, our in vivo transduction strategies are suitable for pre-clinical protocol development for gene delivery to granule cells by AAVrh10 and Purkinje cells by AAV-PHPeB.
The exploration of anti-Vibrio parahaemolyticus substances from Phellodendri Chinensis Cortex as a preservative for shrimp storage

This study aimed to optimize the ultrasonic-assisted extraction of the anti-Vibrio parahaemolyticus substances of Phellodendri Chinensis Cortex (ASPC), identify their active substances, and investigate their application in shrimp storage. The ultrasonic-assisted extraction conditions of ASPC were optimized through a single-factor experiment combined with response surface methodology. The optimal parameters were the ethanol concentration of 81%, the ultrasonic power of 500 W, the temperature of 80°C, the extraction time of 23 min, and the liquid/solid ratio 25 ml/g. The antibacterial zone diameter of the obtained extract determined by agar well diffusion method was 15.56 ± 0.22 mm, which was not significantly different from the predicted value (15.92 mm). Berberine was identified as one of the main chemical components of ASPC through high-performance liquid chromatography combined with standard control. The minimum inhibitory concentrations of ASPC and berberine determined by the tube dilution method were 0.25 and 0.03 mg/ml, respectively. The application of ASPC in shrimp storage showed that it could effectively inhibit the proliferation of V. parahaemolyticus on shrimps. This report offers good prospects for the use of Phellodendri Chinensis Cortex as a potential preservative against V. parahaemolyticus in aquatic products.
Identification of cuproptosis-related subtypes, cuproptosis-related gene prognostic index in hepatocellular carcinoma

Cuproptosis is a novel form of cell death, correlated with the tricarboxylic acid (TCA) cycle. However, the metabolic features and the benefit of immune checkpoint inhibitor (ICI) therapy based on cuproptosis have not yet been elucidated in Hepatocellular carcinoma (HCC). First, we identified and validated three cuproptosis subtypes based on 10 cuproptosis-related genes (CRGs) in HCC patients. We explored the correlation between three cuproptosis subtypes and metabolism-related pathways. Besides, a comprehensive immune analysis of three cuproptosis subtypes was performed. Then, we calculated the cuproptosis-related gene prognostic index (CRGPI) score for predicting prognosis and validated its predictive capability by Decision curve analysis (DCA). We as well explored the benefit of ICI therapy of different CRGPI subgroups in two anti-PD1/PD-L1 therapy cohorts (IMvigor210 cohort and GSE176307). Finally, we performed the ridge regression algorithm to calculate the IC50 value for drug sensitivity and Gene set enrichment analysis (GSEA) analysis to explore the potential mechanism. We found that cluster A presented a higher expression of FDX1 and was correlated with metabolism, glycolysis, and TCA cycle pathways, compared with the other two clusters. HCC patients with high CRGPI scores had a worse OS probability, and we further found that the CRGPI-high group had high expression of PD1/PDL1, TMB, and better response (PR/CR) to immunotherapy in the IMvigor210 cohort and GSE176307. These findings highlight the importance of CRGPI serving as a potential biomarker for both prognostic and immunotherapy for HCC patients. Generally, our results provide novel insights about cuproptosis into immune therapeutic strategies.
Characterization of PM2.5-bound trace elements, source apportionment, and assessment of associated human health risks during summer and winter in Greater Noida, the National Capital Region of India

To examine the trends of particulate matter with aerodynamic diameter ≤2.5 µm (PM2.5) and its elemental constituents during two distinct seasons at a site away from the city center of Delhi and the National Capital Region (Delhi-NCR) of India, this unique study aimed at the development of source-receptor-effect linkages. This research paper presents results of occurrence, long-range transport (LRT), source apportionment, and human health impact assessment of 24 PM2.5-bound trace elements (Al, Ba, Bi, Ca, Cd, Co, Cr, Cu, Fe, Ga, K, Li, Mg, Mn, Na, Ni, Pb, S, Se, Si, Te, Tl, Zn, and Zr). The concentration of PM2.5 during winter (296 ± 45 μg/m3) was significantly higher than in summer (114 ± 48 μg/m3) and exceeded 24 h Indian standard on most of the measurement days. The seasonal concentration ratios (winter/summer) of individual elements varied from 1.7 (Si) to 5.9 (Tl). The backward trajectory of air masses showed that transboundary transport of pollutants occurred in the downwind direction during winter, indicating that this remote site was affected by transported particulates and local activities. The principal component analysis–absolute principal component score (PCA-APCS) model confirmed five significant sources, vehicles (22.3%), soil/road dust (23.1%), coal combustion (20.9%), open burning (13.8%), and other industries (10.2%) responsible for particulate emission. The results from the multiple path particle dosimetry model (MPPD) showed higher deposition of particulates in the human respiratory system occurred during winter (44%) than in summer (40%). The elements with crustal sources of origin had a higher deposition fraction in the head region (0.27 for Si) compared to elements of anthropogenic sources (0.13 for Li). The excess lifetime carcinogenic risk (ELCR) under winter episodic events increased significantly at 128 × 10−6 compared to the summer non-episodic period at 41 × 10−6.
Structural analysis of VirD4 a type IV ATPase encoded by transmissible plasmids of Salmonella enterica isolated from poultry products

Bacterial species have evolved with a wide variety of cellular devices, and they employ these devices for communication and transfer of genetic materials and toxins. They are classified into secretory system types I to VI based on their structure, composition, and functional activity. Specifically, the bacterial type IV secretory system (T4SS) is a more versatile system than the other secretory systems because it is involved in the transfer of genetic materials, proteins, and toxins to the host cells or other bacterial species. The T4SS machinery is made up of several proteins with distinct functions and forms a complex which spans the inner and outer membranes. This secretory machinery contains three ATPases that are the driving force for the functionality of this apparatus. At the initial stage of the secretion process, the selection of substrate molecules and processing occurs at the cytoplasmic region (also known as relaxosome), and then transfer mechanisms occur through the secretion complex. In this process, the VirD4 ATPase is the first molecule that initiates substrate selection, which is subsequently delivered to the secretory machinery. In the protein data bank (PDB), no structural information is available for the VirD4 ATPase to understand the functional property. In this manuscript, we have modeled VirD4 structure in the Gram-negative bacterium Salmonella enterica and described the predicted functional importance. The sequence alignment shows that VirD4 of S. enterica contains several insertion regions as compared with the template structure (pdb:1E9R) used for homology modeling. In this study, we hypothesized that the insertion regions could play a role in the flexible movement of the hexameric unit during the relaxosome processing or transfer of the substrate.