Miracle-dz/UniFAR-FTUs huggingface dataset:
Avaliação do efeito da roxitromicina na regressão da hiperplasia gengival induzida pela Ciclosporina em ratos

A hiperplasia gengival (HG) e um efeito colateral comum do uso cronico da ciclosporina (CsA), imunossupressor amplamente usado em pacientes transplantados para evitar a rejeicao de orgaos. Estudos recentes demonstraram niveis elevados de citocinas especificas no tecido gengival hiperplasiado, principalmente o TGF- , sugerindo que esse fator de crescimento tenha um papel no acumulo da matriz extracelular visto na hiperplasia gengival. O tratamento para essa complicacao, ate pouco tempo, era somente cirurgico. Hoje varios estudos demonstraram a eficacia da azitromicina, antibiotico macrolideo, na regressao desse efeito colateral indesejado causado pelo imunossupressor. No presente estudo, foi realizado um modelo experimental para avaliacao do efeito terapeutico da roxitromicina na HG. Foram utilizados 32 ratos divididos em quatro grupos, com inducao da HG em cinco semanas e tratamento com a droga na 6a semana (grupo A – animais que receberam salina; grupo B – animais que receberam CsA e foram tratados com salina na 6a semana; grupo C – animais que receberam CsA e, na 6a semana, ampicilina e grupo D – animais que receberam CsA durante 5 semanas e, na seguinte, foram tratados com roxitromicina). Portanto, neste estudo foi avaliado o efeito da roxitromicina no tratamento da HG. Adicionalmente, a expressao do fator de crescimento transformador beta (TGF- 2) foi investigado, atraves da tecnica de imunohistoquimica, pelo metodo do complexo avidina-biotina peroxidase antiperoxidase, com a finalidade de melhor compreender a patogenese da HG. Os resultados demonstraram que a roxitromicina foi efetiva na regressao da hiperplasia gengival induzida pela ciclosporina em ratos. Houve reducao significativa da mucosa gengival, com reducao do numero de fibroblastos, das areas de fibrose e de infiltrado inflamatorio, assim como da expressao do TGF- 2 em ratos tratados com a roxitromicina quando comparados com os grupos controles. Portanto, os dados sugerem que a diminuicao da expressao do TGF- 2 pode ser um importante mecanismo de acao pelo qual a roxitromicina inibe a HG.
(PHAR03) The effects of palm vitamin E supplementation on oxidative status in steroid-induced cataract formation

Introduction Almost 16 million people were reported worldwide to be blind and about 50 million have impaired vision as a result of cataract (Thylerors et al., 1995). In developing countries, including India and Kenya, blindness resulting from cataract appeared earlier in life and is more prevalent than in developed countries (Taylor, 2000). Cataract formation is associated with aging, eye injury, smoking, diabetes, excessive exposure to light and steroid (Jacob, 1999). While the mechanism of initiation and progression of being investigated, there is still no consolidated theory, which can predict the course of route of cataractogenesis. It is believed that oxidative stress appears to play a key role in cataract formation, which it can cause oxidation on lens lipid and protein (Brown, 2001). Vitamin E has long been known appears to be highly efficient as an antioxidant to protect the body from free radical damage, which is well accepted as the first line of defense against lipid peroxidation. Vitamin E naturally occurring tocopherol and tocotrienol isomers present in palm oil. Some of the tocopherol isomers present in palm oil, the tocotrienol, are not normally present in the other edible oils (Packer, 1991). Some reported vitamin E effectively inhibits and delay cataract formation (SunYuh & Cristina, 2000). Thus the present study aims to determine the effects of palm vitamin E supplementation on oxidative status in steroid-induced cataract formation.
Synthesis, characterization, and application of molecular imprinting polymer for extraction of melamine from spiked milk, water, and blood serum

Abstract Molecularly imprinted polymers (MIPs) of melamine (MEL) were synthesized by non-covalent approach with precipitation polymerization. In this research, MEL was used as the template molecule, acrylamide (AAm) as the functional monomer, divinylbenzene (DVB) as the cross-linker, 2,2′-azobisisobutyronitrile (AIBN) as an initiator, and the mixture of dimethyl sulfoxide (DMSO) and acetonitrile (ACN) was used as a reaction medium. The imprinted and non-imprinted polymer particles were characterized by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), Brunauer–Emmett–Teller (BET), and thermogravimetric analysis (TGA). The rebinding efficiency was evaluated for all the synthesized polymers by batch binding analysis. The adsorption studies such as adsorbent dosage of polymer, initial concentrations, and pH of MEL solution were successfully conducted on the selected polymer. For selectivity test, 2,4,6-trichlorophenol (2,4,6-TCP) was selected as competitive molecule against the MEL. A good removal efficiency of MEL from different samples such as milk (81.97%), river water (91.52%), and human blood serum (90.66%) was achieved. GRAPHICAL ABSTRACT
The Cytotoxicity and Insecticidal Activity of Extracts from Delphinium formosum Boiss. & Huet

DOI : 10.26650/IstanbulJPharm.2019. 19034 Delphinium species are well-known toxic plants with their diterpenoid alkaloid contents. There has been no previous investigation on the cytotoxicity of Delphinium formosum Boiss. & Huet. The extracts of the different parts of D. formosum, an endemic species in Turkey, were investigated for their cytotoxic activity against the human liver carcinoma cell line (HepG2) and primary human umbilical vein endothelial cells (HUVEC). The cytotoxic effects of twelve extracts and subfractions were determined against HepG2 cells using MTT assay. The only active extract was applied to the HUVEC as a model for healthy cells. Only one of the alkaloid-containing extracts from the aerial parts was toxic (IC50 = 244,9 μg/mL against HepG2 and 144,4 μg/mL against HUVEC), while the root extracts were inactive. The results were improbable although it’s predicted secondary metabolites, such as diterpene alkaloids (methyllycaconitine, browniine, lycoctonine, avardharidine, antranoyllycoctonine, delsemine A/B and lycoctonine). Based on previous studies in literature, the cytotoxic plants were also expected to exhibit insecticidal activity. Therefore, the cytotoxic extract of D. formosum was examined for its adulticidal and larvicidal activity against the yellow fever, dengue fevers and Zika virus vector Aedes aegypti L. You may cite this article as : Sen-Utsukarci B, Tabanca N, Estep AS, Akbal-Dagistan O, Kessler SM, Ozturk Z, Becnel J, Kiemer AK, Mat A (2019). The Cytotoxicity and Insecticidal Activity of Extracts from Delphinium formosum Boiss. & Huet. Istanbul J Pharm 10.26650/IstanbulJPharm.2019. 19034.
CD4+ T Cell‐Released Extracellular Vesicles Potentiate the Efficacy of the HBsAg Vaccine by Enhancing B Cell Responses

T cells secrete bioactive extracellular vesicles (EVs), but the potential biological effects of CD4+ T cell EVs are not clear. The main purpose of this study is to investigate the effects of CD4+ T cell–derived EVs on B cell responses and examine their role in antigen‐mediated humoral immune responses. In this study, CD4+ T cell EVs are purified from activated CD4+ T cells in vitro. After immunization with the Hepatitis B surface antigen (HBsAg) vaccine, CD4+ T cell EVs‐treated mice show stronger humoral immune responses, which is indicated by a greater Hepatitis B surface antibody (HBsAb) level in serum and a greater proportion of plasma cells in bone marrow. In addition, it is found that EVs released from activated CD4+ T cells play an important role in B cell responses in vitro, which significantly promote B cell activation, proliferation, and antibody production. Interestingly, antigen‐specific CD4+ T cell EVs are found to be more efficient than control EVs in enhancing B cell responses. Furthermore, it is shown that CD40 ligand (CD40L) is involved in CD4+ T cell EVs‐mediated B cell responses. Overall, the results have demonstrated that CD4+ T cell EVs enhance B cell responses and serve as a novel immunomodulator to promote antigen‐specific humoral immune responses.
Complexation of curcumin with whey protein isolate for enhancing its aqueous solubility through a solvent‐free pH‐driven approach

In this study, whey protein isolate (WPI) was employed to increase the water dispersibility of curcumin using a solvent‐free pH shifting method (pH 12 to pH values of 7.0 and 3.0). The aqueous solubility of curcumin was significantly improved by this method compared to the method without pH shifting at pH values of 7.0 and 3.0. Fluorescence measurements and Fourier transform infra‐red (FT‐IR) spectroscopy revealed that the complexation occurs through the hydrogen bonding and hydrophobic interactions between curcumin and WPI. Circular dichroism (CD) spectroscopy and X‐ray diffraction (XRD) analysis indicated that the secondary structures and crystallinity of WPI at pH values of 7.0 and 3.0 did not significantly change after binding to curcumin. The complexation with WPI greatly improved the heat‐ and photo‐stability of curcumin with a higher stability at pH 3.0 than at pH 7.0. WPI‐curcumin complexes also showed a high antioxidant activity and sustained‐release profile under simulated intestinal condition. PRACTICAL APPLICATIONS: In this research, a solvent‐free pH shifting approach was used to produce curcumin‐WPI complexes for improving the aqueous solubility, chemical stability, and antioxidant activity of curcumin. The resulting curcumin‐WPI complexes could be used in the aqueous formulation of functional foods and beverages owing to their high water dispersibility, excellent antioxidant activity, and good chemical stability which can improve the health‐promoting attributes of the food products.
Anterior Cruciate Ligament Functional Sports Asssessment

The incidence of anterior cruciate ligament (ACL) patients has doubled in the past 5 years at Rush University Orthopaedics. Additionally, there has been a 3-fold increase in the number of anterior cruciate ligament injuries in patients younger than the age of 25 years of age during this 5-year period. Fortunately, approximately 80%-90% of these patients return to their sports at their previous level of play. However, with the increased incidence in tears, it is important for medical providers to assist the patients in determining the risk factors they may display when preparing to return to sport. There are very few published return to sport guidelines following anterior cruciate ligament reconstruction. Midwest Orthopaedics at Rush has developed a functional sports assessment (FSA) to evaluate anterior cruciate ligament injury risk factors on postoperative patients. The FSA factors include range-of-motion, strength, endurance, proprioception, power, core stability, ankle stability, and overall biomechanics and confidence. Although the FSA has not been proven reliable or valid, it is based on the other commonly used tasks in determining a patient’s ability after anterior cruciate ligament surgery. It has been clinically relevant for the patient, therapist, athletic trainer, and physician in identifying weaknesses and risk factors at the 5-6 month time postoperative time period. This helps to guide the patient in what tasks he or she needs to be attentive to during the transition to return to sport to minimize reinjury. This article provides factors that were considered when developing the FSA, a detailed description of the FSA, and future considerations to improve the assessment for validity and reliability.
Fantasy-Theme Analysis of Food Documentaries: Contention, Collaboration, and Consultation as Health Promotion Approaches

In this study, the medium of documentary film is explored as a potential healthpromotion tool. Food documentaries have become more popular recently, and the public’s awareness of food-related health issues is growing. By analyzing different approaches to documentary films about food, I unpack the many functions and social perceptions of food with regard to health. Using fantasy-theme analysis, I explore the visions of the filmmakers of three food documentaries and the health-promotion strategies employed within them. Three different approaches to motivating healthbehavior change emerged from the documentaries—contention, collaboration, and consultation. Each documentary employed a different well-established and effective health-behavior change model. The findings of this study have implications for positioning entertaining sources of health information that are not typically used for health promotion practices as important and useful tools for health information dissemination, increasing knowledge and awareness of food and health issues, and promoting positive health-behavior change.
Yield and quality of densely cultivated onion cultivars as function of nitrogen fertilization

ABSTRACT Nitrogen exerts a marked influence on the yield and quality of the onion. The present work was developed from June to October 2016, aiming to evaluate the yield and quality of two cultivars of onion under a system densified as a function of nitrogen doses in Mossoró, RN, Brazil. A randomized block design was used in a 2 x 7 factorial scheme, with four repetitions, corresponding to two cultivars (IPA 11 and Rio das Antas) and seven nitrogen doses (0, 45, 90, 135, 180, 225 and 270 kg ha-1 of N), provided by fertigation, with four repetitions. The dose of 92 kg ha-1 of N provides the highest total and marketable yields of bulbs. Nitrogen fertilization increases the concentrations of N, chlorophyll a, b and total in the leaves of the onion, as well as the percentage of bulbs of classes 3 and 4 and the pungency, reducing the percentage of bulbs of class 2 and non-commercial. The doses of 108 and 82 kg ha-1 of N provide the highest rates of return for ‘IPA 11’ (R$ 2.07) and ‘Rio das Antas’ (R$ 2.41), respectively.
Electric-field-induced simultaneous diffusion of Mg and H in Mg-doped GaN prepared using ultra-high-pressure annealing

To investigate Mg diffusion during ultra-high-pressure annealing, which activates Mg acceptors in GaN, GaN samples with p–n junctions prepared via epitaxial growth were annealed at 1573 K under 1 GPa. The profiles of Mg diffusion toward the underlying n-type layer cannot be explained by a simple diffusion model. We found that H atoms diffused along with Mg atoms. By considering the suppressed diffusion of positively charged interstitial H atoms due to the electric field in the depletion layer, we could better reproduce the Mg–H diffusion profiles, suggesting that H atoms play a key role in the Mg diffusion process.
Progress in Pretreatment and Analysis of Fatty Acids in Foods: An Update since 2012

Fatty acids (FAs) are a class of lipids found in everyday foods that are closely related to human health. These chemicals are involved in many physiological functions. The establishment of methods for the analysis of FAs in different foods is necessary. In this review, an updated overview of the pretreatment and analysis methods that have been reported since 2012 is given. Sample preparation methods involve extraction, fractionation and derivatization, while analysis methods involve chromatographic, spectral, and electrophoretic methods, as well as several other methods. Different pretreatment and determination methods are discussed.
Nursing students experience and attitudes to computers: A survey of a cohort of students on a Bachelor in Nursing Studies course

Background The need for addressing the issue of training nursing students in Health Informatics [the discipline dealing with the application of information and communications technology (ICT) to health care] and incorporating training in the basic information technology skills is becoming a matter for much discussion. Literature reports that the previous computer experience of nurses can generate a positive or negative attitude to a specific computer system and influence the motivation to acquire new computer knowledge. Attempts to address this matter in Ireland came with the recommendation by the Syllabus of Nurse Training 2000 that ICT be included as a taught component within the curriculum. The lack of emphasis on ICT being taught as a formal component with no guidelines as to what level this ICT component should reflect, do little to assist either nurse educators or programme developers. Literature on information and communications technology in health care generally, and in nursing and midwifery education specifically, is now expand
The Effect of Aerobic Exercises on Blood Glucose Concentration in Healthy Girls and Girls with Type 1 Diabetes Mellitus

Regular aerobic exercises are beneﬁ cial not only for healthy people. Physical activity plays a big part in the lives of children and adolescents with type 1 diabetes mellitus too. Walking, biking, swimming, dancing, and many other activities are considered to be aerobic exercises and they are all healthy. What kind of physical exercises are the most useful for the youth with type 1 diabetes mellitus? So, the aim of the present study was to estimate and compare the effect of aerobic exercise such as swimming and aerobics, on blood glucose concentration of young girls. 19 girls aged 16.5 ± 0.24 years with the duration of diabetes for 8.1 ± 0.9 years and 28 healthy girls aged 16.9 ± 0.36 years participated in the study. Two experiments were carried out. The ﬁ rst experiment was a 7-day physical exercise program, consisting of aerobics and swimming training sessions each day. The other experiment was a 14-week swimming program, where all the participants attended swimming training sessions two times per week, and there were all in all 28 training sessions. Glycemia control was assessed by blood glucose level (mmol / l) monitored before and after every training sessions during the 7-day and 14-week physical programs. After the analysis of blood test it was found, that the 7-day physical program decreased blood glucose concentration for all subjects (p < 0.05) but, swimming had a greater effect on blood glucose control for girls with type 1 diabetes mellitus than aerobics (p < 0.01). After the 14-week duration swimming program, hyperglycemia signiﬁ cantly decre-ased for all subjects too, but it’s response to the regular physical activity in the water was the highest for diabetics (p < 0.001). The evidence obtained in this study showed that both swimming and aerobics decreased blood glucose concentration for healthy subject and for subjects with diabetes. But swimming had a greater effect on the dynamics of blood glucose level for girls with type 1 diabetes mellitus than aerobics.Keywords: type 1 diabetes mellitus, swimming, aerobics, blood glucose, glycemia.
Green solution to corrosion problems – at a glance

Extracts of natural products are used as corrosion inhibitors since they are non toxic and environmentally friendly. Especially the extracts of leaves have attracted the attention of many researchers. Usually weight loss methods are adopted to measure the corrosion inhibition efficiencies. The mechanistic aspects have been investigated by electrochemical studies such as polarization study and AC impedance spectra. Sometimes noise measurement has also been used. The protective films formed on the metal surface have been analysed by surface analysis techniques such as SEM, EDAX, FTIR and AFM. Experiments have been carried out at various temperatures also. Various adsorption isotherms have been proposed. Of all the metals and alloys used, mild steel has been extensively used. The experiments have been carried out in acid medium and neutral medium (sodium chloride). The extracts of the leaves contain many ingredients which have polar groups such as N, O, S and P atoms. The lone pair of electrons present on these atoms are pumped on to the metal surface. This controls the corrosion process.
Evaluation of phytochemical contents and antioxidant activity of pomegranate flower

Pomegranate is one of the most abundant fruit consumed in Turkey. This study aimed to determine the content of total phenolic, total flavonoid and antioxidant activity of Punica granatum L. flower in different extracts. Antioxidant activities of different extracts were determined 2,2-diphenyl-1-picrylhydrazyl (DPPH•) radical scavenging, reducing power and metal chelating methods. The result showed that, total phenolic content for the extracts was ranged from 14.82 to 90.86 mg gallic acid equivalents(GAE) / g extract. The contents of flavonoids were found to range from 7.35 to 500.00 mg quercetin equivalents (QUE)/ g extract. All pomegranate flower extracts displayed remarkable antioxidant activity according to DPPH and reducing power assays. Especially the methanolic extract of pomegranate flower possesses significant scavenging activity against DPPH• (85.80 %), as well as the largest contents of flavonoids and phenolic compounds. The antioxidant capacity of the methanolic extract was also greater than those of BHT and α-tocopherol in DPPH and reducing power assays. The results demonstrated that the antioxidant activity of extracts of Punica granatum L. flower might be, at least in part, due to the existence of high content of flavonoids compounds and other phenolics.
Measurement Error Course Report

In survival analysis, people are interested in the survival probability of a patient or the reoccurrence rate of a disease given the patient’s medical status and received treatments. Usually, the observed survival times are right-censored because, for example, some patients drop off the study. Typically, the observed data for each patient are denoted as (Ti,∆i, Xi), i = 1, . , n, where n is the total number of observations, Ti is the possibly right-censored survival time, 1−∆i is the indicator for censoring, and Xi is the covariate vector. The Cox proportional hazard model is commonly used to model the survival time as a function of covariates. The hazard rate is assumed to have the form
Designing optimally‐graded depth filter media using a novel multiscale method

Even though current manufacturing methods allow to build precisely-defined graded depth filter media, it remains unclear which local filtration properties are desirable. We, therefore, introduce a multiscale approach which links pore and continuum scale (PS and CS) to address this question. Based on data from PS simulations, local filtration performance, as described by the filter coefficient, is predicted on the CS by an optimal control solution and the obtained trajectory is translated back to the PS where it is validated. Two case studies are presented: a bidisperse fibrous medium and a granular depth filter composed of bidisperse particles. Both media are optimized to achieve a homogenous deposition of separated impurities along the filter depth. It is found that the presented method allows to reach this goal reasonably well in both cases. We claim that our method forms a good basis for further developments for which promising possibilities are highlighted.