Miracle-dz/UniFAR-FTUs huggingface dataset:
Regulatory network underlying alterations of gene expression in early death of Huntington's disease

The aim of this study is to explore the genomic mechanism of early death in Huntington’s disease (HD). We identified 10160 and 1511 differentially expressed genes (DEGs) from comparisons of HD versus control and early versus late death, respectively. On the basis of 922 overlapped DEGs among them, six functional modules were established by weight gene correlation network analysis. The turquoise module most strongly related to overall survival of HD was significantly enriched in GABAergic synapse, retrograde endocannabinoid signaling and neuroactive ligand-receptor interaction. Low expression of five DEGs (CA10, WSB2, ACTR3B, PCDH19 and GABRB3) with highest degree of connectivity and non-zero regression coefficients were identified as hub genes, based on which the LASSO model exactly predicted the occurrence of early death in HD. Furthermore, the network analysis revealed indirect interaction of CA10 with the central hub gene GABRB3, which was involved in the pathway of GABAergic synapse. Compared with high expression of hub genes, their low expression appeared shorter overall survival of HD patients according to Kaplan-Meier survival analysis. Consequently, low expression of CA10, WSB2, ACTR3B, PCDH19 and GABRB3 were possibly associated with early death of HD. The likelihood of low expression of GABRB3 regulated by CA10 in GABAergic synapse contributed to the pathogenesis of early death in HD.
Sliding Mode Impedance Control for Dual Hand Master Single Slave Teleoperation Systems

For the purpose of avoiding injury and realizing precise operations, the multilateral teleoperation system is the most efficient way to transport trace toxic or radioactive substances, to perform minimally invasive surgery, etc. It is essential to enhance the transparency of a multilateral teleoperation system including multiple masters and the single slave manipulator. However, there are few researchers focus on the allocation of the contact force of the single slave manipulator to different master manipulators. In this paper, we firstly introduce the concept of force translation for teleoperation systems consisting of dual hand master (left and right hands) manipulators and a single slave manipulator. Force translation reflects how the impedance on the single slave side is translated or allocated to contact forces on different master sides. To maintain the stability of the system and to improve transparency, we elucidate the mechanism of the force translation and analyze the relation among masters and the slave. Furthermore, the force translation mechanism is analyzed through numerical simulations and CHAI 3D virtual physical simulations. It is used to propose a multilateral impedance control, and the Lyapunov function is used to analyze the system stability. The results of numerical simulations and real robot experiments verify the effectiveness of the proposed control methods based on the proposed force translation mechanism.
PdI2-Catalyzed synthesis of heterocycles

Some PdI 2 -based complexes have proved to be efficient catalysts for the selective, atom-economical synthesis of different important heterocyclic derivatives starting from very simple building blocks, such as simple or functionalized alkynes, amino alcohols, diamines, carbon monoxide, carbon dioxide, alcohols, water, and oxygen. The synthetic protocols leading to heterocycles have been grouped into three classes of reactions: (a) cycloisomerization of (Z)-2-en-4-yn-1-ols, (Z)-2-en-4-yne-1-thiols, (Z)-(2-en-4-ynyl)amines, 2-alkynylbenzyl alcohols to give substituted furans, thiophenes, pyrroles, and 1,3-dihydroisobenzofurans or 1H-iso-chromenes, respectively; (b) oxidative carbonylation of simple alkynes, 1,5-diynes, functionalized alkynes bearing a suitably placed nucleophilic group, amino alcohols, and diamines to afford substituted maleic anhydrides, functionalized p- and γ-lactones, β- and γ-lactams, dihydroindol-2-ones, furans, pyrroles, thiophenes, tetrahydrofurans, oxazolidin-2-ones, oxazolines, cyclic ureas, 4H-3,1-benzoxazines, quinazolin-2-ones, quinolin-4-ones; (c) reductive carbonylation of alkynes to give substituted γ-lactones and formation of lactone or anhydride derivatives by additive carbonylation, resulting from the combination between oxidative carbonylation of the triple bond and reduction of a suitable functional group present in the substrate itself.
A 56-Gbps PAM4 amplitude-rectification-based receiver with threshold adaptation and 1-tap DFE

This paper presents a 56-Gbps four-level pulse amplitude modulation (PAM4) quarter-rate receiver based on amplitude rectiﬁcation. Compared with the conventional three-comparator structure, the PAM4 signal is converted into a 2-digit gray-code rather than a 3-digit thermometer-code. Theamplitudeisdetectedtodecodetheleastsigniﬁcantbit(LSB),whichallowstheproposedreceivertousesigniﬁcantlylesspower byreducingthenumberofcomparators.Aninverter-basedcommon-modevoltagestabilizationcircuit(CVSC)isproposedtoreducetheeﬀectof common-modelevelchangesastheamplitudeisdetermined.Tominimizethefeedbackdelay,the2-digitgray-codeisfedbacktoDFE’ssummer directly.Byreducingthedigitofthefeedbacksignal,thepowerwillbefurtherreducedastheDFEtapincreases.Thedeviceconsumes83. 5mW overa55-nmprocess. key words: PAM4, receiver, amplitude-rectiﬁcation-based
Resetting education priorities during COVID-19: Towards equitable learning opportunities through inclusion and equity

Worldwide, COVID-19 has affected the most deprived communities the hardest and exposed many systemic inequalities, leaving nations vulnerable and destitute. The need for quality education, while heeding to international mandates, including enacting the sustainable development goals (SDG), has become more apparent in promoting equitable and inclusive education for all, which remains a challenge in South Africa with its inherited inequalities. The purpose of this study was to understand how the COVID-19 challenge refocused the commitment of five principals from rural schools in two education districts of the Northern Cape province of South Africa to address resurfaced historic inequalities, including digital access and fluency to attain an equitable learning environment. Semi-structured emailed interviews were conducted with the participants. A thematic analysis of their experiences of the pandemic through the lens of flexible learning theory, revealed that teachers and learners often experienced discrimination-related stress, especially with virtual learning approaches, as schools often cannot offer remote services to advance learning. Furthermore, the participants voiced their uncompromising commitment to inclusion while engaging teachers and learners in identifying possible problems and proposing solutions post-COVID-19. Though the current crisis seems to have perpetuated and deepened existing inequalities in disadvantaged rural South African schools, some school principals are hopeful that as the reality has now been laid bare, it may prompt more urgent action. The paper recommends that school principals and teachers will have to refocus teaching practices towards flexible, inclusively delivered teaching through working collaboratively across disciplines so that they build their personal resilience and advance their technological skills to meet the demands of remote and online learning during a pandemic and beyond. physical disabilities; we use it to improve their reading skills, as well as their creative and critical abilities.
Effectiveness of antioxidant treatments on cytochrome P450 2E1 (CYP2E1) activity after alcohol exposure in humans and in vitro models: A systematic review

ABSTRACT This systematic review aimed to describe the effects of antioxidant treatments after alcohol exposure in humans and in vitro models. A systematic review of quantitative studies to identify the effectiveness of antioxidant treatments on CYP2E1 activity after alcohol consumption. Multiple databases were searched from 2010 to May 2020 for studies in English, using MeSH terms and text words relating to antioxidant treatments, CYP2E1 and, alcohol consumption. The protocol is registered on PROSPERO CRD42021226123. Study quality was assessed using the NICE methodology. The review is reported according to PRISMA. A total of eight original articles were analyzed. All papers collected and reported quantitative data. Antioxidant treatments could be beneficial after alcohol exposure to improve oxidative stress by decreasing CYP2E1 activity and increasing GSH levels. Our results suggest that antioxidant treatments could be beneficial and effective during ethanol exposure in human or in vitro models.
ASSESSING THE USE OF LIDAR AND UAV TECHNOLOGY FOR MONITORING GROWING ALFALFA

OF THESIS ASSESSING THE USE OF LIDAR AND UAV TECHNOLOGY FOR MONITORING GROWING ALFALFA Alfalfa is a popularly grown crop because of its value as a nutritious feed source for livestock. The efficient production of an alfalfa crop relies on the monitoring of certain parameters, like height, quality, and yield. Traditionally, producers have used manual measurements of alfalfa plant height to estimate the nutritive quality and yield of a growing alfalfa crop. Manual measurements of plant height are often labor intensive and provide low resolution data that is not acceptable for full field scale assessment of growing alfalfa. The two studies presented in this thesis offer detailed insight into the rapid and accurate monitoring of alfalfa with LiDAR and UAV technologies. The first study explores the use of a simple single beam LiDAR sensor to accurately estimate the average canopy height and yield of an alfalfa crop. Predictive models of alfalfa canopy height were developed and evaluated to find the optimal LiDAR derived measurements to use. The resulting measurements were then used to build predictive models of yield, and the best yield model was determined. The best models of canopy height and yield both incorporated the 95th percentile of LiDAR derived canopy height as a single explanatory variable. The second study assesses the field conditions, flight parameters, and general statistical descriptors that should be considered for the stable collection and application of UAV derived canopy height information. Data taken from different alfalfa fields at different flight parameters with different statistical processing were all compared. General canopy height distribution statistics from UAV flights flown at or below 50 m with nadir and oblique camera angles over thick stands of alfalfa were determined to be reliable for the detection and application of the alfalfa canopy surface. Using these determined methods, predictive models of canopy height and yield were generated and compared. The best model of average canopy height used the 50th percentile of UAV derived canopy height from an UAV flight at 30 m in a nadir imaging configuration. The best model of yield used the 95th percentile from an UAV flight at 50 m in an oblique imaging configuration.
155 GHz FMCW and Stepped-Frequency Carrier OFDM Radar Sensor Transceiver IC Featuring a PLL With <30 ns Settling Time and 40 fs rms Jitter

A radar transceiver with two transmitters (TXs) and two receivers (RXs) is reported in 22 nm fully depleted silicon-on-insulator (FDSOI) CMOS. It includes a novel 200 MHz bandwidth 80 GHz phase-locked loop (PLL) based on a single-sideband (SSB) upconverter and an 11 GHz bandwidth phase-frequency detector to achieve >8 GHz locking range with record phase noise of −97, −103, and −113 dBc/Hz at 100 kHz, 1 MHz, and 10 MHz offset, respectively, and rms jitter < 40 fs. Stepped-frequency chirps with orthogonal frequency-division multiplexing (OFDM) modulation covering the 152–160 GHz range were demonstrated in a through-the-air loopback link along with a record settling time < 30 ns, limited by the test equipment. The RXs have an IIP3 of −8 dBm, SSB noise figure between 7.5 and 10 dB and a conversion gain of 15 dB, controllable from the LNA back gate over a range of 12 dB. The OP1 dB and $P_{\mathrm {SAT}}$ of the power amplifier (PA) in each TX are 5 and 9 dBm, respectively. The IQ amplitude mismatch and phase error of each RX are < 0.5 dB and 1°, respectively, while the $P_{\mathbf {out}}$ mismatch between the TXs is < 1 dB. The sensor consumes 1.13 W, with 300 mW by the PLL, 275 mW by the 160 GHz local oscillator (LO)-tree, 190 mW by each TX, and 87.5 mW by each RX.
IDENTIFIKASI MOLEKULER SIRIP IKAN HIU MENGGUNAKAN GEN MITOKONDRIA CYTOCHROME C OXYDASE SUBUNIT I (COI) YANG DIDARATKAN DI PESISIR KABUPATEN BANGKA SELATAN

Usaha perikanan hiu yang menjanjikan di negara Indonesia ini menjadikan nilai produksi hiu terus meningkat dari tahun ke tahun. Menurut catatan FAO, Indonesia berada diposisi teratas yang banyak memproduksi hiu setiap tahunnya. Tingginya aktivitas penangkapan hiu berpengaruh besar terhadap populasi yang memengaruhi keseimbangan ekosistem laut, khususnyadi perairan Kepulauan Bangka Belitung. Tujuan penelitian ini yaitu untuk mengidentifikasi sirip ikan hiu secara molekuler dengan menggunakan gen mitokondria cytochrome c oxydase subunit I (COI) yang didaratkan di pesisir Kabupaten Bangka Selatan. Metode penelitian terdiri dari tiga tahap: pengumpulan sampel sirip ikan hiu, identifikasi molekuler (mtDNA gen Cytochrome Oxidase Subunit 1 /COI), analisis filogenetik dan status konservasi ikan hiu. Hasil pencocokan karakter nukleotida gen COI dilakukan dengan menggunakan program BLAST yang terintegrasi pada laman GenBank dan menunjukkan bahwa kode sampel MSPUBB_HC_01 memiliki tingkat kemiripan 100% dengan spesies Chiloscyllium punctatum , MSPUBB_HK_02 dan MSPUBB_HS_03 masing-masing memiliki tingkat kemiripan 99.80% dan 99.69% dengan spesies Carcharhinus sealei. Jika ditinjau dari data IUCN Red List, spesies Chiloscyllium punctatum dan Carcharhinus sealei masuk dalam kategori Near threatened (Hampir Terancam).
Kinetic study on eutectic reaction between boron carbide and stainless steel by differential thermal analysis

after the thinning experiment for the B 4 C–SS eutectic reaction. Though the findings and knowledge obtained in the thinning experiment are not based on the results of in-situ measurement for the eutectic Abstract In a postulated severe accidental condition of sodium-cooled fast reactor (SFR), the eutectic reaction between boron carbide (B 4 C) as control rod element and stainless steel (SS) as control rod cladding or related structure materials may take place. Thus, the kinetic behavior of the B 4 C–SS eutectic reaction is one of the important phenomena to be considered when evaluating the core disruptive accidents in SFR. In this study, for the first step to obtain the fundamental information on kinetic feature of the B 4 C–SS eutectic reaction and compare the pervious findings, the thermal analysis using the pellet samples of B 4 C and Type 316L SS as a different experimental approach was performed up to 1773 K at different heating rates of 2.5-10 K min -1 . The differential thermal analysis (DTA) endothermic peaks for the B 4 C–SS eutectic reaction appeared from 1483K to 1534K and systematically shifted to higher temperatures with increasing heating rate. Based on this kinetic feature, apparent activation energy and pre-exponential factor for the B 4 C–SS eutectic reaction were determined by Kissinger method. It was found that the kinetic parameters obtained by thermal analysis were comparable to the literature values of the thinning experiment at high temperatures. In addition, the microstructure and element distribution formed in the interdiffusion layer composed of the B 4 C–SS system were analyzed by the electron probe microanalyzer (EPMA), which can provide key validation data on elemental interdiffusion behavior in the early stage of the eutectic reaction for reflecting the reaction kinetic modeling. As a result of three Element mapping shows that was small of and It was also shown that concentrated Cr and in Layer II, and Ni at the boundary between Layers II and III.
Determination, Reproducibility and Illustration of the Helical Axes of the knee after Total Arthroplasty

The biomechanical models are evolving in order to be as close as possible to the clinic. Quantified movement analysis offers predictive and / or functional methods that help determine and model functional axes known as helical axes that seem today to represent the means closest to human joint movement. The knee is a joint with complex movements subject to kinematic modifications. The knee joint changes that occur during life seem to modify the helical axes and disrupt the kinematics of the joint. These alterations cause joint replacements by total knee arthroplasty which have the particularity of being based on the knee axes in order to restore the anterior kinematics of the knee with the aim of early functional recovery. The current design of total knee prostheses makes it possible to partially restore the functional axes of the knee, which could in the long-term cause biomechanical disturbances responsible for sometimes unsatisfactory results.
A fixed dose approach to thrombosis chemoprophylaxis may be inadequate in heavier critically ill patients

Objectives: Overweight patients are at greater risk of venous thromboembolism. We aimed to describe prescribing patterns of thrombosis chemoprophylaxis in critically ill patients weighing ≥ 100 kg and quantify the effectiveness of these regimens using the surrogate biomarker of plasma anti-Xa level. Design, setting and patients: A prospective single-centre cohort study was conducted over a 6-month period. Patients weighing ≥ 100 kg who were prescribed enoxaparin for chemoprophylaxis and expected to remain in the intensive care unit for > 48 hours were eligible. Anti-Xa levels were measured once a patient had received at least three consecutive doses of enoxaparin. Peak levels were measured 4–6 hours after the third dose and trough levels were measured before the fourth dose. Anti-Xa levels were compared with established target ranges for peak and trough anti-Xa levels (0.2–0.5 IU/mL and > 0.1 IU/mL, respectively). Results: Eighty-eight patients met the eligibility criteria, and anti-Xa levels for 42 patients were obtained. Fixed dose chemoprophylaxis approaches varied considerably, with 40 mg once daily (54/88 [61%]) and 40 mg twice daily (20/88 [23%]) being the most frequently prescribed regimens. No patient had a peak anti-Xa level > 0.5 IU/mL. When comparing 40 mg once daily versus twice daily, the once daily regimen had lower median trough levels (0.01 IU/mL [interquartile range (IQR), 0.00–0.04] v 0.09 IU/mL [IQR, 0.05–0.13]; P < 0.001) and greater proportions of patients with levels below the established range (< 0.1 IU/mL) (15/16 [95%] v 7/14 [50%]; P = 0.002) and levels that were undetectable (0.00 IU/mL) (8/16 [50%] v 1/14 [7%]; P = 0.01). Conclusions: At a single centre, thrombosis chemoprophylaxis prescribing patterns for heavier critically ill patients varied considerably. Current fixed dose approaches may be inadequate in this cohort.
Induire une écoute audiotechnique au moyen de la stéréophonie monumentale. Musique pour les premiers spectacles son et lumière

Ecouter le son spatialise au moyen d’appareils electroniques constitue une des nouvelles experiences arrivees au lendemain de la Seconde Guerre mondiale. En ce qui concerne l’histoire de cette nouvelle forme d’ecoute audiotechnique en France, l’une des manifestations du son stereophonique qui a eu le plus d’impact aupres du public fut sans doute les spectacles son et lumiere, dont le premier de l’histoire eut lieu en 1952 au château de Chambord, avec une musique signee Maurice Jarre. La partie sonore de ce spectacle etait le fruit d’un dispositif stereophonique inedit. Les spectacles son et lumiere ont initie de nombreux auditeurs a une nouvelle forme d’ecoute directionnelle, une habilete exploitee ensuite par une generation de compositeurs d’avant-garde. Cet article se penche sur la dimension musicale de ces spectacles afin de mesurer leur impact sur l’entrainement de l’oreille du public general a la musique qui conquit l’espace au moyen de la stereophonie.
Energy-Efficient Convolution Module With Flexible Bit-Adjustment Method and ADC Multiplier Architecture for Industrial IoT

Offloading the unprecedented growing data to the edge exhibits a mainstream trend in the Industrial Internet of Things (IIoT) era, delivering far-reaching impacts in all aspects of our daily lives, including transportation, health care, and entertainment. However, voluminous data analyzes and processing at the edge will unavoidably raise the edge processor's burden and dramatically expand its design complexity and energy dissipation. This article proposes a flexible bit-adjustment-based energy-efficient convolution module with an approximate divide-and-conquer (ADC) multiplier for compact and low-power edge processor design. The maximum distribution search technique is utilized to exploit the optimal fixed-point representation format for both input and output of the convolution module. The neural network manifests the same precision as a 32-b floating-point multiplication deploying the determined representation formats. An ADC multiplier is proposed to realize the convolution module by eliminating the high-bit multiplication between weights and feature maps. The dynamic power consumption of the ADC multiplier-based convolution module with the <inline-formula><tex-math notation="LaTeX">$Q(6, 9)$</tex-math></inline-formula> input and <inline-formula><tex-math notation="LaTeX">$Q(7, 8)$</tex-math></inline-formula> output representation formats is 3.85% lower than that of the 16-b signed multiplication circuit. Furthermore, the dynamic power consumption with <inline-formula><tex-math notation="LaTeX">$Q(6, 9)$</tex-math></inline-formula> input is capable of being decreased by 15.38% for the 16-b convolution if the output is represented by the <inline-formula><tex-math notation="LaTeX">$Q(1, 14)$</tex-math></inline-formula> format and by up to 39.93% for the 64-b multiplication. The practical verification system of the convolution module working on a field-programmable gate array evaluation board exhibits an outstanding low-power characteristic.