Miracle-dz/UniFAR-FTUs huggingface dataset:
Syndrome: Systematic Review and Recommendations: A Scientific Statement From the Depression as a Risk Factor for Poor Prognosis Among Patients With Acute Coronary

D epression and elevated depressive symptoms are common among the estimated 15.4 million US adults with coronary heart disease (CHD). 1 Approximately 20% of patients hospitalized for an acute coronary syndrome (ACS; myocardial infarction [MI] or unstable angina [UA]) meet the American Psychiatric Association’s Diagnostic and Background —Although prospective studies, systematic reviews, and meta-analyses have documented an association between depression and increased morbidity and mortality in a variety of cardiac populations, depression has not yet achieved formal recognition as a risk factor for poor prognosis in patients with acute coronary syndrome by the American Heart Association and other health organizations. The purpose of this scientific statement is to review available evidence and recommend whether depression should be elevated to the status of a risk factor for patients with acute coronary syndrome. Methods and Results —Writing group members were approved by the American Heart Association’s Scientific Statement and Manuscript Oversight Committees. A systematic literature review on depression and adverse medical outcomes after acute coronary syndrome was conducted that included all-cause mortality, cardiac mortality, and composite outcomes for mortality and nonfatal events. The review assessed the strength, consistency, independence, and generalizability of the published studies. A total of 53 individual studies (32 reported on associations with all-cause mortality, 12 on cardiac mortality, and 22 on composite outcomes) and 4 meta-analyses met inclusion criteria. There was heterogeneity across studies in terms of the demographic composition of study samples, definition and measurement of depression, length of follow-up, and covariates included in the multivariable models. Despite limitations in some individual studies, our review identified generally consistent associations between depression and adverse outcomes. Conclusions —Despite the heterogeneity of published studies included in this review, the preponderance of evidence supports the recommendation that the American Heart Association should elevate depression to the status of a risk factor for adverse medical outcomes in patients with acute coronary syndrome.
M ICROPROPAGATION OF A V ALUABLE E THNOMEDICINAL P LANT S TREBLUS ASPER L OUR .

SUMMARY A micropropagation protocol is presented for conservation of critically threatened woody tree species, Streblus asper Lour. In vitro axillary bud proliferation followed by multiple shoot induction was obtained using mature nodal segments. Initially, explants were cultured on Murashige and Skoog’s medium supplemented with different concentrations of BA (2.2, 4.4, 6.6, 8.9, 11.1 and 13.3 µM), Kn (2.3, 4.6, 6.9, 9.3, 11.6 and 13.9 µM) or TDZ (2.2, 4.5, 6.7, 8.90, 11.1 and 13.5 µM). These individual levels of cytokinins did not support in vitro shoot regeneration in S. asper . Combinations of cytokinins, Kn with BA or TDZ, significantly influenced shoot regeneration ability. The combination of Kn (4.60 µM) with BA (4.44 µM) evoked an optimum response towards shoot proliferation whereas, medium containing Kn (4.60 µM) plus TDZ (4.54 µM) induced multiple shoot formation. In vitro developed microshoots were rooted on MS half strength medium supplemented with 2.46 µM IBA. The plantlets established in vitro were transferred to pots containing sterilized soil and vermiculite (1:1) mixture and were hardened in the greenhouse with 70-75% survival rate. woody tree, Multiple shoot induction Abbreviations: BA - 6-benzyladenine, IBA - indole 3-butyric acid, Kn - kinetin, µM - micro moles, MS – Murashige and Skoog TDZ - thidiazuron
Creation, dissemination, and evaluation of videos to promote COVID-19 vaccination in India: A research protocol

Background: Vaccine hesitancy is one of the greatest challenges to the success of coronavirus disease 2019 (COVID-19) vaccination campaigns. Videos promoting vaccines have a narrow scope focusing solely on facts, and less on the emotional and narrative elements of communication that can be equally persuasive. The role of humor, for example, has remained largely unexplored. Objective: This study investigates whether theory-based videos can change people’s attitudes, beliefs, and intentions to receive the second COVID-19 vaccine. Our primary research question is: How do collectivistic and individualistic appeals, humor, and protagonist gender individually and jointly affect vaccination attitudes, beliefs, and intentions? Methods: This project tapped into the underutilized Indian film industry—the world’s largest film producer—to promote vaccination messaging through short videos. Feedback from a community advisory board was utilized to inform the video scripts that were then shot by a production team. Eight videos were filmed and shared by adopting a 2 (appeal: individualistic or collectivistic) x 2 (tone: humor or non-humor) x 2 (protagonist gender: male or female) between-subjects design approach. Our sample includes Odia-speaking participants aged between 18 – 35 years old randomly assigned to watch one of the eight study videos. An online survey questionnaire, social media network analysis, and small group qualitative interviews will be utilized to explore how the entertainment-education videos can be used to reduce vaccine hesitancy. Discussion: Vaccine messages do not fall into a cultural or cognitive vacuum. People process and make sense of information based on their prior experience, properties of the message, and their social environment. Yet, these considerations have taken secondary importance in vaccine communications. This research shows that it is possible to deliver high-caliber videos created in accordance with the audience's cultural and cognitive background. Conclusions: This study will inform future health promotion messaging through brief videos on the internet.
Significant formation of sulfate aerosols contributed by the heterogeneous drivers of dust surface

Abstract. The importance of dust heterogeneous oxidation in the removal of atmospheric SO2 and formation of sulfate aerosols is not adequately understood. In this study, the Fe-, Ti-, and Al-bearing components, Na+, Cl−, K+, and Ca2+ of the dust surface, were discovered to be closely associated with the heterogeneous formation of sulfate. Regression models were then developed to make a reliable prediction of the heterogeneous reactivity based on the particle chemical compositions. Further, the recognized gas-phase, aqueous-phase, and heterogeneous oxidation routes were quantitatively assessed and kinetically compared by combining the laboratory work with a modelling study. In the presence of 55 µg m−3 airborne dust, heterogeneous oxidation accounts for approximately 28.6 % of the secondary sulfate aerosols during nighttime, while the proportion decreases to 13.1 % in the presence of solar irradiation. On the dust surface, heterogeneous drivers (e.g. transition metal constituents, water-soluble ions) are more efficient than surface-adsorbed oxidants (e.g. H2O2, NO2, O3) in the conversion of SO2, particularly during nighttime. Dust heterogeneous oxidation offers an opportunity to explain the missing sulfate source during severe haze pollution events, and its contribution proportion in the complex atmospheric environments could be even higher than the current calculation results. Overall, the dust surface drivers are responsible for the significant formation of sulfate aerosols and have profound impacts on the atmospheric sulfur cycling.
Multi-Laboratory Hazard Assessment of Contaminated Microplastic Particles by Means of Enhanced Fish Embryo Test With the Zebraﬁsh ( Danio rerio ) As wide-spread pollutants

in the marine environment, microplastics (MPs) have raised public concern about potential toxic effects in aquatic organisms, and, among others, MPs were suspected to act as a vector for organic pollutants to biota. The purpose of the present study was to investigate effects by three model pollutants, oxybenzone (BP3), benzo[a]pyrene (BaP), and perﬂuorooctane sulfonate (PFOS) adsorbed to polyethylene MPs on the basis of a standard assay, the acute ﬁsh embryo toxicity test (FET; OECD TG 236) with zebraﬁsh ( Danio rerio ) supplemented by additional endpoints such as induction of ethoxyresoruﬁn-O-deethylase (EROD) activity, modiﬁcation of cyp1a gene transcription and changes in larval swimming behavior. FET assays were performed in three laboratories using slightly different husbandry and exposure conditions, which, however, were all fully compatible with the limits deﬁned by OECD TG 236. This allowed for testing of potential changes in the FET assay due to protocol variations. The standard endpoints of the FET (acute embryotoxicity) did not reveal any acute toxicity for both virgin MPs and MPs spiked with BP3, BaP, and PFOS. With respect to sublethal endpoints, EROD activity was increased after exposure to MPs spiked with BP3 (3 h pulse) and MPs spiked with BaP (96 h continuous exposure). Cyp1a transcription was increased upon exposure to MPs spiked with BP3 or BaP. For the selected combination of MPs particles and contaminants, the basic FET proved not sensitive enough to reveal effects of (virgin and spiked) MPs. However, given that the FET can easily be supplemented by a broad variety of more subtle and sensitive endpoints, an enhanced FET protocol may provide a relevant approach with developmental stages of a vertebrate animal model, which is not protected by current EU animal welfare legislation (Directive EU 2010/63).
A murine model of myocardial microvascular thrombosis this access benefits you. Your story matters

balance. Such a biological system would likely be con-trolled at the endothelium level (14). We demonstrated previously that the cardiac myocardium regulates the specific activity of its endothelial cells, suggesting a potential role in regulating hemostasis (2). Moreover, fibrin deposition in the cardiac vasculature has a profound effect on heart function; thus, we chose to study this organ bed as a model of thrombus regulation. The use of genetically modified animals provides a power-ful tool for unraveling the complex interactions of the various proteins involved in coagulation homeostasis in the cardiac circulation. In this study, we investigat-ed the interaction of 3 endothelium-derived genes — TM, tPA, and urokinase-type plasminogen activator (uPA) — and their effects on myocardial thrombosis. TM, a natural anticoagulant, is a membrane-bound protein that facilitates the activation of protein C to activated protein C (APC) when thrombin is also Disorders of hemostasis lead to vascular pathology. Endothelium-derived gene products play a critical role in the formation and degradation of fibrin. We sought to characterize the importance of these locally produced factors in the formation of fibrin in the cardiac macrovasculature and microvasculature. This study used mice with modifications of the thrombomodulin (TM) gene, the tissue-type plasminogen activator (tPA) gene, and the urokinase-type plasminogen activator (uPA) gene. The results revealed that tPA played the most important role in local regulation of fibrin deposition in the heart, with lesser contributions by TM and uPA (least significant). Moreover, a syner-gistic relationship in fibrin formation existed in mice with concomitant modifications of tPA and TM, resulting in myocardial necrosis and depressed cardiac function. The data were fit to a statis tical model that may offer a foundation for examination of hemostasis-regulating gene interactions.
Thoracic extra-coronary calci ﬁ cation for the prediction of stroke: The Multi-Ethnic Study of Atherosclerosis Atherosclerosis

Background and aims: Atherosclerosis is a systemic disease. We examined whether the cumulative burden of thoracic extra-coronary calci ﬁ cation (ECC) improves prediction of stroke, transient ischemic attack (TIA), and stroke mortality beyond traditional risk factors and coronary artery calcium (CAC). Methods: We followed a total of 6805 participants (mean age 62.1 ± 10.2 years, 47.2% male) from the Multi-Ethnic Study of Atherosclerosis (MESA) over a median of 12.1 years. The presence or absence of calci ﬁ cation at 4 thoracic ECC sites (mitral valve annulus, aortic valve, aortic root, and thoracic aorta) was determined from baseline cardiac-gated non-contrast CT scans. A multisite thoracic ECC score, ranging 0 e 4, was calculated by summing the 4 individual sites, which were treated as binary variables. Multivariable Cox proportional hazards regression models, controlled for traditional risk factors and CAC, were used to estimate hazard ratios for ischemic (primary endpoint) and hemorrhagic stroke, total stroke, TIA, and stroke mortality with increasing thoracic ECC. Results: With an increasing number of thoracic ECC sites, there was a signi ﬁ cant ( p < 0.05) multivariable adjusted step-wise increase in the risk for ischemic stroke (n ¼ 184), total stroke (n ¼ 235), and TIA (n ¼ 85), but not hemorrhagic stroke (n ¼ 32) and stroke mortality (n ¼ 42). Thoracic ECC increased the c-statistic and net reclassi ﬁ cation index beyond traditional risk factors and CAC, but the results were not signi ﬁ cant ( p > 0.10). Conclusions: Although multisite thoracic ECC is independently associated with ischemic stroke, total stroke, and TIA, the incremental predictive value of thoracic ECC beyond traditional risk factors and CAC appears to be minimal.
Linear Secret Sharing Schemes and Rearrangements of Access Structures

In this paper we study linear secret sharing schemes by monotone span programs, according to the relation between realizing access structures by linear secret sharing schemes and computing monotone Boolean functions by monotone span programs. We construct some linear secret sharing schemes. Furthermore, we study the rearrangements of access structures that is very important in practice.
MINIREVIEW An Oracle: Antituberculosis Pharmacokinetics-Pharmacodynamics, Clinical Correlation, and Clinical Trial Simulations To Predict the Future (cid:1)

Antimicrobial pharmacokinetic-pharmacodynamic (PK/PD) science and clinical trial simulations have not been adequately applied to the design of doses and dose schedules of antituberculosis regimens because many researchers are skeptical about their clinical applicability. We compared ﬁndings of preclinical PK/PD studies of current ﬁrst-line antituberculosis drugs to ﬁndings from several clinical publications that included microbiologic outcome and pharmacokinetic data or had a dose-scheduling design. Without exception, the antimi- crobial PK/PD parameters linked to optimal effect were similar in preclinical models and in tuberculosis patients. Thus, exposure-effect relationships derived in the preclinical models can be used in the design of optimal antituberculosis doses, by incorporating population pharmacokinetics of the drugs and MIC distributions in Monte Carlo simulations. When this has been performed, doses and dose schedules of rifampin, isoniazid, pyrazinamide, and moxiﬂoxacin with the potential to shorten antituberculosis therapy have been identiﬁed. In addition, different susceptibility breakpoints than those in current use have been identiﬁed. These steps outline a more rational approach than that of current methods for designing regimens and predicting outcome so that both new and older antituberculosis agents can shorten therapy duration. the (TB) suf-fered
Ce ﬁ derocol for compassionate use in the treatment of complicated infections caused by extensively and pan-resistant Acinetobacter baumannii Journal of Global Antimicrobial Resistance

Objective: This study presents real-life experience with ce ﬁ derocol used on a compassionate basis for treatment of three patients with severe infections caused by extensively/pan-drug resistant (XDR/PDR) Acinetobacter baumannii (Ab). Methods: Serum bactericidal activity was determined and considered as a surrogate of ce ﬁ derocol susceptibility. Results: Clinical improvement and microbiological eradication of A. baumannii were observed in all three patients, who were affected by extremely complex conditions either for type of infection, adverse effect or resistance pro ﬁ le of A. baumannii . Conclusion: Ce ﬁ derocol for XDR/PDR-Ab infections might be reconsidered, especially in light of the recent disappointing results of the CREDIBLE-CR study.
The directional error curve as booth elliptical lemniscate

There are two aspects of position coordinates accuracy in navigation: global accuracy and local accuracy – relative to navigational dangers. The latter case refers to the assessment of position (distance) accuracy in re-spect to the nearest navigational danger, a hazard to navigation. The directional error is a relevant measure for such assessment. The directional error curve is analyzed in this article as a particular case of the Booth elliptical lemniscate. The curve graph illustrates the confidence interval of point position errors in a given direction (about 68%).
DEVELOPMENT AND EVALUATION OF MOUTH DISSOLVING ORO-DISPERSIBLE PELLETS OF MECLIZINE HCL USING EXTRUSION AND SPHERONIZATION TECHNIQUE

Among all the dosage forms conventional forms are convenient way to administer, and even more easy when preparation like Oro dispersible tablets or pellets administered which directly get into systemic circulations. Pellatization is a technique which achieves control release rate of drugs when coated with suitable polymers. For formulation, drug-excipients incompatabilities were carried out by FTIR and DSC. Among all the F2(SD-1:2) was having std results for particle size (2.57), Bulk density(0.406±0.004), Tapped density(0.498±0.003), Cars index(8.535±0.002), Hausners ratio(1.023±0.001). Pellet were evaluated for F2, Pellet size(0.80±0.015mm), Disintegration(50.9±0.020sec), Wetting time(4.0min), Friability(0.7±0.036%). In vitro dissolution test reveals the release increase from 50% to a maximum of almost 100% for 30 min. The release is in the following order of Formulation F2> F1> F5> F3> F4.
Improved Prediction of Perceived Fluency of Japanese English using Quantity of Phonation and Quality of Pronunciation

To support people to learn a new language, various types of technical aids have been examined [1, 2] and realized as commercial products or services [3, 4]. This paper presents research results of a joint project between UTokyo and UCL, where teachers asked engineers to automatize their fluency scoring strategy. In this study, prediction is conducted with Elastic Net regression with speech features. Experimental results demonstrate that posteriorgram with multiple granularities is effective for prediction and a high correlation of 0.925 is obtained between machine scores and the scores of perceived fluency averaged over 10 native raters. This value is higher than the average of inter-rater correlations of 0.873.
Safety and Efﬁcacy of Intravenous Ferric Derisomaltose Compared to Iron Sucrose for Iron Deﬁciency Anemia in Patients with Chronic Kidney Disease With and Without Heart Failure

Ferric derisomaltose (FDI) is an intravenous (IV) high-dose iron formulation approved in the US for the treatment of iron deﬁciency anemia in adults who are intolerant of/have had an unsatisfactory response to oral iron, or who have non-dialysis-dependent chronic kidney disease (NDD-CKD). FERWON-NEPHRO was a randomized, open-label, multicenter clinical trial evaluating the safety and efﬁcacy of a single infusion of FDI 1,000 mg versus up to 5 doses of iron sucrose (IS) 200 mg (recommended cumulative dose, 1,000 mg) over 8 weeks in patients with NDD-CKD and iron deﬁciency anemia. Of 1,525 patients included in the safety analysis, 244 (16%) had a history of heart failure (HF). Overall, the rate of serious or severe hypersensitivity reactions was low and did not differ between treatment groups. Cardiovascular adverse events (AEs) were reported for 9.4% of patients who had HF and 4.2% who did not. Time to ﬁrst cardiovascular AE was longer following administration of FDI compared with IS (hazard ratio: 0.59 [95% CI: 0.37, 0.92]; p=0.0185), a difference that was similar in patients with or without HF (p=0.908 for interaction). Patients achieved a faster hematological response (assessed by changes in hemoglobin and ferritin concentrations, and increase in transferrin saturation) with FDI versus IS. In conclusion, in patients with NDD-CKD, a single infusion of FDI was
The Effect of Intensive Glycemic Control and Diabetic Complications on Lower Urinary Tract Symptoms (LUTS) in Men with Type 1 Diabetes: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study

1. Division of Research, Kaiser Permanente, Northern California Region, Oakland, CA 94612 2. Departments of Epidemiology and Urology, University of Michigan, Ann Arbor, MI 3.The Biostatistics Center, The George Washington University, Rockville, MD 4. NIDDK, National Institutes of Health, Bethesda, MD 5. Department of Urology, Northwestern University, Chicago, IL 6. Department of Urology, University of Washington School of Medicine and Harborview Medical Center, Seattle, WA
A genome-wide analysis of the response to inhaled β2-agonists in chronic obstructive pulmonary disease.

Short-acting β 2 -agonist bronchodilators are the most common medications used in treating chronic obstructive pulmonary disease (COPD). Genetic variants determining bronchodilator responsiveness (BDR) in COPD have not been identified. We performed a genome-wide association study (GWAS) of BDR in 5789 current or former smokers with COPD in one African American and four white populations. BDR was defined as the quantitative spirometric response to inhaled β 2 -agonists. We combined results in a meta-analysis.
Current Control for Dual 3-Phase PM Synchronous Motors Accounting for Current Unbalance and Harmonics

1 Abstract — This paper proposes an improved vector space decomposition current control scheme for dual 3-phase magnet (PM) synchronous motors having two sets of 3-phase windings spatially shifted by 30 electrical degrees. A PI and resonant (2nd) controller is developed for eliminating the current unbalance in αβ sub-plane, which is effective irrespective of the degree of current unbalance, whilst PI plus multi-frequency resonant (2nd and 6th) control is employed to eliminate the current unbalance , 5th and 7th current harmonics in z 1 z 2 sub-plane. Compared with existing methods only accounting for current unbalance in z 1 z 2 sub-plane, the proposed method has taken into account the current unbalances in both z 1 z 2 and αβ sub-planes and can eliminate them simultaneously at the steady state of operation. Consequently, the full compensation of current unbalance can be achieved, by which both the current unbalance between two sets and current unbalance between phase windings in each set are eliminated. Meanwhile, the 5th and 7th current harmonics caused by non-sinusoidal back EMF and inverter non-linearity can also be fully compensated. The effectiveness of proposed method is verified by a set of comparative experiments on a prototype dual 3-phase PM machine system. It shows that fully balanced currents without the 5th and 7th current at the steady state of operation can be achieved.