Miracle-dz/UniFAR-FTUs huggingface dataset:
Weight Reduction Through a Digital Nutrition and Food Purchasing Platform Among Users With Obesity: Longitudinal Study

Background Digital nutrition apps that monitor or provide recommendations on diet have been found to be effective in behavior change and weight reduction among individuals with obesity. However, there is less evidence on how integration of personalized nutrition recommendations and changing the food purchasing environment through online meal planning and grocery delivery, meal kits, and grocery incentives impacts weight loss among individuals with obesity. Objective The objective of this observational longitudinal study was to examine weight loss and predictors of weight loss among individuals with obesity who are users of a digital nutrition platform that integrates tools to provide nutrition recommendations and changes in the food purchasing environment grounded in behavioral theory. Methods We included 8977 adults with obesity who used the digital Foodsmart platform, created by Zipongo, Inc, DBA Foodsmart between January 2013 and April 2020. We retrospectively analyzed user characteristics and their associations with weight loss. Participants reported age, gender, height, at least 2 measures of weight, and usual dietary intake. Healthy Diet Score, a score to measure overall diet quality, was calculated based on responses to a food frequency questionnaire. We used paired t tests to compare differences in baseline and final weights and baseline and final Healthy Diet Scores. We used univariate and multivariate logistic regression models to estimate odds ratios and 95% CI of achieving 5% weight loss by gender, age, baseline BMI, Healthy Diet Score, change in Healthy Diet Score, and duration of enrollment. We conducted stratified analyses to examine mean percent weight change by enrollment duration and gender, age, baseline BMI, and change in Healthy Diet Score. Results Over a median (IQR) of 9.9 (0.03-54.7) months of enrollment, 59% of participants lost weight. Of the participants who used the Foodsmart platform for at least 24 months, 33.3% achieved 5% weight loss. In the fully adjusted logistic regression model, we found that baseline BMI (OR 1.02, 95% CI 1.02-1.03; P<.001), baseline Healthy Diet Score (OR 1.06, 95% CI 1.05-1.08; P<.001), greater change in Healthy Diet Score (OR 1.12, 95% CI 1.11-1.14; P<.001), and enrollment length (OR 1.28, 95% CI 1.23-1.32; P<.001) were all significantly associated with higher odds of achieving at least 5% weight loss. Conclusions This study found that a digital app that provides personalized nutrition recommendations and change in one’s food purchasing environment appears to be successful in meaningfully reducing weight among individuals with obesity.
Programmed DNA Damage and Physiological DSBs: Mapping, Biological Significance and Perturbations in Disease States

DNA double strand breaks (DSBs) are known to be the most toxic and threatening of the various types of breaks that may occur to the DNA. However, growing evidence continuously sheds light on the regulatory roles of programmed DSBs. Emerging studies demonstrate the roles of DSBs in processes such as T and B cell development, meiosis, transcription and replication. A significant recent progress in the last few years has contributed to our advanced knowledge regarding the functions of DSBs is the development of many next generation sequencing (NGS) methods, which have considerably advanced our capabilities. Other studies have focused on the implications of programmed DSBs on chromosomal aberrations and tumorigenesis. This review aims to summarize what is known about DNA damage in its physiological context. In addition, we will examine the advancements of the past several years, which have made an impact on the study of genome landscape and its organization.
XFinger-Net: Pixel-Wise Segmentation Method for Partially Defective Fingerprint Based on Attention Gates and U-Net

Partially defective fingerprint image (PDFI) with poor performance poses challenges to the automated fingerprint identification system (AFIS). To improve the quality and the performance rate of PDFI, it is essential to use accurate segmentation. Currently, most fingerprint image segmentations use methods with ridge orientation, ridge frequency, coherence, variance, local gradient, etc. This paper proposes a method of XFinger-Net for segmenting PDFIs. Based on U-Net, XFinger-Net inherits its characteristics. The attention gate with fewer parameters is used to replace the cascaded network, which can suppress uncorrelated regions of PDFIs. Moreover, the XFinger-Net implements a pixel-level segmentation and takes non-blocking fingerprint images as an input to preserve the global characteristics of PDFIs. The XFinger-Net can achieve a very good segmentation effect as demonstrated in the self-made fingerprint segmentation test.
Sex-Specific Transcriptome Differences in Human Adipose Mesenchymal Stem Cells

In humans, sexual dimorphism can manifest in many ways and it is widely studied in several knowledge fields. It is increasing the evidence that also cells differ according to sex, a correlation still little studied and poorly considered when cells are used in scientific research. Specifically, our interest is on the sex-related dimorphism on the human mesenchymal stem cells (hMSCs) transcriptome. A systematic meta-analysis of hMSC microarrays was performed by using the Transcriptome Mapper (TRAM) software. This bioinformatic tool was used to integrate and normalize datasets from multiple sources and allowed us to highlight chromosomal segments and genes differently expressed in hMSCs derived from adipose tissue (hADSCs) of male and female donors. Chromosomal segments and differentially expressed genes in male and female hADSCs resulted to be related to several processes as inflammation, adipogenic and neurogenic differentiation and cell communication. Obtained results lead us to hypothesize that the donor sex of hADSCs is a variable influencing a wide range of stem cell biologic processes. We believe that it should be considered in biologic research and stem cell therapy.
Improved Determination Method of Free Amino Acids in Soy Sauce by Capillary Electrophoresis with Indirect Ultraviolet Detection

Byc apillarye lectrophoresisw ithi ndirectu ltravioletd etection, sixa minoa cids, namely alanine, serine, valine, leucine, glutamic acid and aspartic acid were detected in Tris (pH=10.50) where benzoic acid was taken as its setting electrolyte. Under the optimum conditions, these six amino acids were well separated within 5 minutes. The relative standard deviation (RSD) of the method was better than 5%. The linear calibration range was 10～1000μmolL and the detection limit were 2.0, 3.5, 4.0, 5.0, 3.5 and 5.0μmol L respectively. Their recoveries were all in the range of 95.73%～104.46%.
The impact of knowledge, self-efficacy, and stigma on STI testing intention among college students

Abstract Objective: Young people represent over half of the new cases of sexually transmitted infections (STIs) each year in the United States. This study examined how STI knowledge, self-efficacy, and stigma impact STI testing intention among sexually active college students using path model analysis. Participants: Participants included 76 college students (74.1% undergraduate, M age = 23.05). Method: Data were collected via online survey. Path analysis was conducted using SPSS AMOS, and MacKinnon’s ab product approach in RMediation was used to test mediating effects. Results: The hypothesized path model fit the data well and the relationships between self-efficacy and knowledge, stigma, and STI testing intention were significant. Mediation analysis revealed significant indirect paths for knowledge and stigma on STI testing intention through self-efficacy. Conclusion: Findings suggest that college health providers may be able to increase the frequency of STI testing behavior by promoting strategies to increase students’ self-efficacy.
Immune-engineered H7N9 influenza hemagglutinin improves protection against viral influenza virus challenge

ABSTRACT The influenza hemagglutinin (HA) isolated from avian H7N9 influenza virus strains elicit weak immune responses. This low immunogenicity may be due to a regulatory T cell (Treg)–stimulating epitopes in HA from the H7N9 isolate A/Anhui/1/2013 (Anh/13). In this report, this Treg stimulating sequence was removed from the wild-type (WT) H7 HA amino acid sequence and replaced with a conserved CD4 + T cell stimulating sequences from human seasonal H3N2 strains and designed OPT1 H7 HA. The effectiveness of this optimized H7 HA protein was determined using a humanized mouse (HLA-DR3) expressing the human leukocyte antigen (HLA) DR3 allele. HLA-DR3 mice were pre-immunized by infecting with H3N2 influenza virus, A/Hong Kong/4108/2014 and then vaccinated intramuscularly with either the WT H7 HA from Anh/13 or the OPT1 H7 HA antigen without adjuvant. The OPT1 H7 HA vaccination group elicited higher H7 HA-specific IgG titers that resulted in a lower mortality, weight loss, and lung viral titer following lethal challenge with the H7N9 Anh/13 influenza virus compared to WT-vaccinated mice. Overall, T-cell epitope-engineered vaccines can improve the immunogenicity of H7 HA antigens resulting in enhanced survival and lower morbidity against H7N9 influenza virus challenge.
Nurse managers experiences of their leadership roles in a specific mining primary healthcare service in the West Rand

Background Nurse managers are leaders in mining primary healthcare. Their leadership roles include inspiring and empowering operational managers and nursing personnel, by leading with competence developing them to become followers with insight and direction. However, these leadership roles are not clearly defined, and are negatively influenced by the traditional mining leadership style. Objectives The aim of this study was to explore and describe the nurse managers’ experiences of their leadership roles in a specific mining primary healthcare service on the West Rand, to develop recommendations to enhance these roles. Method A qualitative, exploratory, descriptive and contextual research design was used in this study, following a phenomenological approach as a research method. A non-probability purposive sampling method was used. Nurse managers described experiences of their leadership roles during individual phenomenological interviews. Data saturation was reached on participant number 7. To analyse data, four stages of Giorgi’s descriptive phenomenological data analysis was used. An independent coder coded the data and a consensus meeting was held. The study was guided by the theoretical framework of Winkler’s role theory. Results The following subthemes emanated from data analysis: (1) leadership role ambiguity, (2) leadership roles experienced and (3) challenges experienced in leadership roles. Conclusion This study revealed that the leadership roles for nurse managers in a specific mining primary healthcare service are not clearly defined. Hence enhancements and expansions of these leadership roles remained stagnant. A clearly defined policy on leadership roles for nurse managers should be developed.
Body Fat Mediates Association between Active Living and Health among Adolescents

The aim of this study was to explore the association of moderate-to-vigorous physical activity and organized leisure-time activities with self-rated health among adolescents and whether these associations are mediated by body fat percentage. We used data on 888 adolescents (mean age 12.97, SD 1.20, 56.0% boys) from the Health Behaviour in School-aged Children (HBSC) study conducted in 2018 in Slovakia. We used logistic regression models to examine associations within self-reported data (moderate-to-vigorous physical activity and organized leisure-time activities with self-rated health) and their mediation by anthropometric data (body fat percentage). The adolescents who were sufficiently physically active and with normal body fat were more likely to report good or excellent health (odds ratios—OR/95% confidence intervals—95% CI: 3.52/1.50–8.27 and 3.66/2.37–5.68). Similarly, the adolescents who were engaged in individual/team sport and with normal body fat were more likely to report good or excellent health (OR/95% CI: 2.04/1.31–3.17 and 3.66/2.37–5.68). Adjustment for body fat percentage reduced the association between moderate-to-vigorous physical activity and self-rated health by 27.6% and the association between leisure-time activities and self-rated health by 30.7%. Active living and normal body fat might contribute to better health in adolescence. Programs and efforts to increase physical activity and leisure-time activities in childhood and adolescence need to identify which aspects of these activities are important, effective, and crucial for the population of adolescents.
The Brassica napus wall‐associated kinase‐like (WAKL) gene Rlm9 provides race‐specific blackleg resistance

SUMMARY In plants, race‐specific defence against microbial pathogens is facilitated by resistance (R) genes which correspond to specific pathogen avirulence genes. This study reports the cloning of a blackleg R gene from Brassica napus (canola), Rlm9, which encodes a wall‐associated kinase‐like (WAKL) protein, a newly discovered class of race‐specific plant RLK resistance genes. Rlm9 provides race‐specific resistance against isolates of Leptosphaeria maculans carrying the corresponding avirulence gene AvrLm5‐9, representing only the second WAKL‐type R gene described to date. The Rlm9 protein is predicted to be cell membrane‐bound and while not conclusive, our work did not indicate direct interaction with AvrLm5‐9. Rlm9 forms part of a distinct evolutionary family of RLK proteins in B. napus, and while little is yet known about WAKL function, the Brassica–Leptosphaeria pathosystem may prove to be a model system by which the mechanism of fungal avirulence protein recognition by WAKL‐type R genes can be determined.
Small intestinal mucosal cells in piglets fed with probiotic and zinc: a qualitative and quantitative microanatomical study.

BACKGROUND Probiotics and zinc are commonly used and beneficial in pig production. This work aimed to assess the effects of probiotic and zinc on the mucosal cells of the small intestine in respect to digestive capacity and immunity in pre and post-weaned piglets. MATERIALS AND METHODS Eighteen LWY piglets were divided equally into control and treatment groups. The piglets were maintained in standard management conditions and were weaned at 28 days of age. The treatment group of piglets fed a mixture of probiotics orally @ 1.25 x 10⁹ CFU/day and zinc @ 2000 ppm/day from birth to 10 days of age. At three different age-groups viz. day 20 (pre-weaning) and, day 30 and day 60 (post-weaning), the animals were sacrificed. For histomorphology, the tissue samples were processed and stained with Mayer's hematoxylin and eosin for routine study, combined PAS-Alcian blue for mucopolysaccharides and Masson-Hamperl argentaffin technique for argentaffin cells. The stained slides were observed under the microscope. The samples were processed as per the standard procedure for scanning and transmission electron microscopy. The statistical analysis of the data using the appropriate statistical tests was also conducted. RESULTS The mucosal epithelium of villi and crypts were lined by enterocytes, goblet cells, argentaffin cells, microfold (M-cell) cells, tuft cells and intraepithelial lymphocytes (IEL). The multipotent stem cells were located at the crypt base. The length of the enterocyte microvilli was significantly longer (P<0.05) in the treatment group of piglets. The number of different types of goblet cells and argentaffin cells was more in treated piglets irrespective of segments of intestine and age. The IEL was located in apical, nuclear and basal positions in the lining epithelium of both villus tip and base with their significant increased in the treatment group of piglets. The TEM revealed the frequent occurrence of tuft cells in the lining mucosa of the small intestine in treated piglets. CONCLUSIONS Dietary supplementation of probiotic and zinc induced the number of different mucosal cells of villi and crypts in the small intestine that might suggest the greater absorptive capacity of nutrients and effective immunity in critical pre and post-weaned piglets.
Ein Beitrag zur Kenntnis der Archaeolacerten (sensu MEHELY, 1909) des Iran (Squamata: Sauria: Lacertidae) Contribution to the knowledge of the archaeolacertids (sensu MÉHELY, 1909) of Iran (Squamata: Sauria: Lacertidae)

A new species of Archaeolacerta from northeastern Iran is described in comparison with other archaeolacertids - chlorogaster and defilippi from Iran, as well as raddei and valentini from Transcaucasia. The systematic status of the new species is discussed on the basis of statistical, ecological, and geographical considerations. KURZFASSUNG Eine neue Archaeolacerten-Art aus dem Nordost-Iran wird beschrieben und mit den Archaeolacerten chlorogaster und dcslippi aus dem Iran sowie mit raddei und valentini aus Transkaukasien verglichen. Der systematische Status der neuen Art wird anhand statistischer, okologischer und geographischer Erwagungen besprochen.
Recent Advances in Biomolecule–Nanomaterial Heterolayer-Based Charge Storage Devices for Bioelectronic Applications

With the acceleration of the Fourth Industrial Revolution, the development of information and communications technology requires innovative information storage devices and processing devices with low power and ultrahigh stability. Accordingly, bioelectronic devices have gained considerable attention as a promising alternative to silicon-based devices because of their various applications, including human-body-attached devices, biomaterial-based computation systems, and biomaterial–nanomaterial hybrid-based charge storage devices. Nanomaterial-based charge storage devices have witnessed considerable development owing to their similarity to conventional charge storage devices and their ease of applicability. The introduction of a biomaterial-to-nanomaterial-based system using a combination of biomolecules and nanostructures provides outstanding electrochemical, electrical, and optical properties that can be applied to the fabrication of charge storage devices. Here, we describe the recent advances in charge storage devices containing a biomolecule and nanoparticle heterolayer including (1) electrical resistive charge storage devices, (2) electrochemical biomemory devices, (3) field-effect transistors, and (4) biomemristors. Progress in biomolecule–nanomaterial heterolayer-based charge storage devices will lead to unprecedented opportunities for the integration of information and communications technology, biotechnology, and nanotechnology for the Fourth Industrial Revolution.
How Does the Location of Transfer Affect Travellers and Their Choice of Travel Mode?—A Smart Spatial Analysis Approach

This study explores the relationship between the spatial distribution of relative transfer location (i.e., the location of the transfer point in relation to the trip origin and destination points) and the attractiveness of the transit service using smart card data. Transfer is an essential component of the transit trip that allows people to reach more destinations, but it is also the main factor that deters the smartness of the public transit. The literature quantifies the inconvenience of transfer in terms of extra travel time or cost incurred during transfer. Unlike this conventional approach, the new “transfer location” variable is formulated by mapping the spatial distribution of relative transfer locations on a homogeneous geocoordinate system. The clustering of transfer points is then quantified using grid-based hierarchical clustering. The transfer location factor is formulated as a new explanatory variable for mode choice modelling. This new variable is found to be statistically significant, and no correlation is observed with other explanatory variables, including transit travel time. These results imply that smart transit users may perceive the travel direction (to transfer) as important, in addition to the travel time factor, which would influence their mode choice. Travellers may disfavour even adjacent transfer locations depending on their relative location. The findings of this study will contribute to improving the understanding of transit user behaviour and impact of the smartness of transfer, assist smart transport planning and designing of new transit routes and services to enhance the transfer performance.
The Design of Large Scale IP Address and Port Scanning Tool

The control network is an important supporting environment for the control system of the heavy ion accelerator in Lanzhou (HIRFL). It is of great importance to maintain the accelerator system’s network security for the stable operation of the accelerator. With the rapid expansion of the network scale and the increasing complexity of accelerator system equipment, the security situation of the control network is becoming increasingly severe. Port scanning detection can effectively reduce the losses caused by viruses and Trojan horses. This article uses Go Concurrency Patterns, combined with transmission control protocol (TCP) full connection scanning and GIMP Toolkit (GTK) graphic display technology, to develop a tool called HIRFL Scanner. It can scan IP addresses in any range with any ports. This is a very fast, installation-free, cross-platform IP address and port scanning tool. Finally, a series of experiments show that the tool developed in this paper is much faster than the same type of software, and meets the expected development needs.
An Observational Study of the Equivalence of Age and Duration of Diabetes to Glycemic Control Relative to the Risk of Complications in the Combined Cohorts of the DCCT/EDIC Study

OBJECTIVE This epidemiological analysis of the pooled Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) cohort describes the equivalence of a 1-percentage point increase in HbA1c (such as from 7% to 8%) and years of additional age or duration of type 1 diabetes (T1D) relative to the risk of complications. RESEARCH DESIGN AND METHODS Separate Cox proportional hazards models determined the number of additional years of age and/or duration of T1D that would result in the same increase in risk of microvascular (retinopathy, nephropathy, and neuropathy) and cardiovascular complications and mortality as a 1-percentage point increase in HbA1c. RESULTS The risk of any cardiovascular disease associated with a 1-percentage point increase in HbA1c was equivalent to the risk associated with 4.3 (95% CI 2.7–5.9) additional years of age or 5.6 (95% CI 2.7–6.5) additional years’ duration of T1D. The risk of estimated glomerular filtration rate <60 mL/min/1.73 m2 and/or end-stage renal disease associated with a 1-percentage point increase in HbA1c was equivalent to the risk associated with 12.1 (95% CI 8.3–15.9) additional years of age or 18.0 (95% CI 4.3–31.7) additional years’ duration of T1D. The proliferative diabetic retinopathy risk associated with a 1-percentage point increase in HbA1c was equivalent to the risk associated with 6.4 (95% CI 5.3–7.4) additional years’ duration of T1D, while for mortality risk, it was equivalent to the risk associated with 12.9 (95% CI 6.6–19.3) additional years of age. CONCLUSIONS Our results help evaluate the impact of glycemia on advanced complications in a way that may be more interpretable to health care providers and individuals with T1D.