Miracle-dz/UniFAR-FTUs huggingface dataset:
Learning from the past to plan for the future: A scoping review of musculoskeletal clinical research in Sweden 2010–2020

Background The aims of this study are to 1) determine the scope of musculoskeletal (MSK)-related clinical research in Sweden; 2) collate the amount of first-tier funding received; 3) discuss strategies and infrastructure supporting future MSK clinical trials in Sweden. Methods A systematic scoping review protocol was applied in PubMed, Scopus, and SweCRIS databases. The articles were examined, and data were extracted in multiple stages by three blinded authors. Results The search strategy resulted in 3,025 publications from 479 Swedish-affiliated authors. Primary health care was the basis for 14% of the publications, 84% from secondary health care, and 2% from occupational health care with a similar proportional distribution of first-tier research grant financing. Approximately one in six publications were randomized controlled trials (RCTs), while the majority were of observational cohort design. The majority of publications in primary and occupational health care were related to pain disorders (51 and 67%, respectively), especially diagnosis, prognosis, and healthcare organizational-related interventions (34%) and rehabilitation (15%) with similar proportional distribution of first-tier research grant financing. In secondary health care, rheumatic inflammatory disorder-related publications were most prevalent (30%), most frequently concerning diagnosis, prognosis, and healthcare organizational-related interventions (20%), attracting approximately half of all first-tier funding. Publications related to degenerative joint disorders (25%), fractures (16%), and joint, tendon, and muscle injuries (13%) frequently concerned surgical and other orthopedic-related interventions (16, 6, and 8%, respectively). Pain disorder-related publications (10%) as well as bone health and osteoporosis-related publications (4%) most frequently concerned diagnosis, prognosis, and healthcare organizational-related interventions (5 and 3%, respectively). Conclusions Swedish-affiliated MSK disorder research 2010–2020 was predominantly observational cohort rather than RCT based. There was skewed first-tier funding allocation considering prevalence/incidence and burden of disease. Use of infrastructure supporting register-based RCTs, placebo-controlled RCTs, and hybrid effectiveness-implementation studies on prevention and clinical intervention is important strategies for the future in all healthcare sectors.
Sanzi Yangqin Decoction Alleviates Allergic Asthma by Modulating Th1/Th2 Balance: Coupling Network Pharmacology with Biochemical Pharmacology

This study aimed to verify that Sanzi Yangqin Decoction (SYD) can relieve asthma in mice and explore the effect on TH1/Th2 balance. The targets of SYD and asthma were explored from the public database using various methods. The potential targets and signaling pathways were identified by KEGG enrichment analysis from DAVID database. Mice asthma models were established using OVA and aluminum hydroxide. Lung tissues of mice were stained with HE and Masson. The contents of IFN-γ, IL-4, and TNF-α in BALF and IgE in mouse serum were detected using ELISA. In addition, the changes in Th1 and Th2 cells of the spleen were detected by flow cytometry. Fourteen core targets including IL4, IFNG, and MMP9 were identified for the treatment of asthma by SYD. The content of IL-4 in the lung tissue and BALF was gradually decreased with the increase in SYD concentration, while the IFN-γ was gradually increased. The drug significantly reduced IgE levels in serum and TNF-α in BALF. The number of Th1 cells in the spleen increased, while Th2 cells decreased in a concentration-dependent manner. SYD can alleviate pulmonary inflammation, restore Th1/Th2 balance, and relieve asthma.
Influence of electron scattering on phonon–plasmon coupled modes dispersion and free‐electron absorption in n‐doped GaN semiconductors at mid‐IR wavelengths

The model to calculate the free‐carrier absorption coefficient for polar III–V semiconductors with strong LO phonon–plasmon interaction was generalized by taking into account free‐carrier scattering by defects The following main mechanisms assisting in the photon absorption process, where taken into account: thermal phonon‐like branch and plasmon‐like branch scattering, impurity scattering, and acoustic phonon scattering. To calculate the contributions of phonon–plasmon coupled modes into the absorption coefficient, the integral dispersion equation for coupled mode frequencies was obtained taking into account free electron scattering by imperfections (mainly by charged impurities in highly doped semiconductors); the dispersion relation of phonon–plasmon coupled modes were calculated versus electron concentration. Computations are performed for α‐GaN and GaN doped semiconductors at different mid‐IR wavelengths and electron concentrations. For all considered cases, the relative difference between the Drude model calculation results based on static and dynamic damping factors is typically smaller than (25–35)%.
Numerical simulation studies of nano-scale surface plasmon components: waveguides, splitters, and filters

In this paper, we theoretically and numerically demonstrate a two-dimensional Metal-Dielectric-Metal (MDM) waveguide based on finite-difference time-domain simulation of the propagation characteristics of surface plasmon polaritons (SPPs). For practical applications, we propose a plasmonic Y-branch waveguide based on MDM structure for high integration. The simulation results show that the Y-branch waveguide proposed here makes optical splitter with large branching angle (~180 degree) come true. We also introduce a finite array of periodic tooth structure on one surface of the MDM waveguide which is in a similar way as FBGs or Bragg reflectors, potentially as filters for WDM applications. Our results show that the novel structure not only can realize filtering function of wavelength with a high transmittance over 92%, but also with an ultra-compact size in the length of a few hundred nanometers, in comparison with other grating-like SPPs filters. The MDM waveguide splitters and filters could be utilized to achieve ultra-compact photonic filtering devices for high integration in SPPs-based flat metallic surfaces.
Named Entity Recognition System for the Biomedical Domain

The recent advancements in medical science have caused a considerable acceleration in the rate at which new information is being published. The MEDLINE database is growing at 500,000 new citations each year. As a result of this exponential increase, it is not easy to manually keep up with this increasing swell of information. Thus, there is a need for automatic information extraction systems to retrieve and organize information in the biomedical domain. Biomedical Named Entity Recognition is one such fundamental information extraction task, leading to significant information management goals in the biomedical domain. Due to the complex vocabulary (e.g., mRNA) and free nomenclature (e.g., IL2), identifying named entities in the biomedical domain is more challenging than any other domain, hence requires special attention. In this paper, we deploy two novel bi-directional encoder-based systems, viz., BioBERT and RoBERTa to identify named entities in the biomedical text. Due to the domain-specific training of BioBERT, it gives reasonably good performance for the NER task in the biomedical domain. However, the structure of RoBERTa makes it more suitable for the task. We obtain a significant improvement in F-score by RoBERTa over BioBERT. In addition, we present a comparative study on training loss attained with ADAM and LAMB optimizers.
A Modified ICP Algorithm Based on FAST and Optical Flow for 3D Registration

This paper presents a modified Iterative Closest Point (ICP) algorithm based on a suitable selection of initial points and local optical flow to speed up registration of static scenes with high accuracy. The biggest disadvantages of using standard ICP algorithm are appropriate initialization and effective matching point step in each iteration. In the proposed modification we deal with these problems and optimize this method for Augmented Reality application. As this application uses RGB-D images sequence the changes between consecutive key-frames are small. Therefore only small subset of the source image key-points is selected using scale-space pyramid and FAST approaches. It leads to the significant reduction of the number of the processed image points. Since the point matching technique using local optical flow is applied, in each optimization step of ICP the costly point matching procedure can be abandoned. The proposed approach has been validated by the numerical examples.
GLOBULAR CLUSTERS AND SPUR CLUSTERS IN NGC 4921, THE BRIGHTEST SPIRAL GALAXY IN THE COMA CLUSTER

We resolve a significant fraction of globular clusters (GCs) in NGC 4921, the brightest spiral galaxy in the Coma cluster. We also find a number of extended bright star clusters (star complexes) in the spur region of the arms. The latter are much brighter and bluer than those in the normal star-forming region, being as massive as 3 × 105 M⊙. The color distribution of the GCs in this galaxy is found to be bimodal. The turnover magnitudes of the luminosity functions of the blue (metal-poor) GCs (0.70 < (V − I) ≤ 1.05) in the halo are estimated V(max) = 27.11 ± 0.09 mag and I(max) = 26.21 ± 0.11 mag. We obtain similar values for NGC 4923, a companion S0 galaxy, and two Coma cD galaxies (NGC 4874 and NGC 4889). The mean value for the turnover magnitudes of these four galaxies is I(max) = 26.25 ± 0.03 mag. Adopting MI (max) = −8.56 ± 0.09 mag for the metal-poor GCs, we determine the mean distance to the four Coma galaxies to be 91 ± 4 Mpc. Combining this with the Coma radial velocity, we derive a value of the Hubble constant, H0 = 77.9 ± 3.6 km s−1 Mpc−1. We estimate the GC specific frequency of NGC 4921 to be SN = 1.29 ± 0.25, close to the values for early-type galaxies. This indicates that NGC 4921 is in the transition phase to S0s.
Establishment and Genetic Profiling of Platinum/Taxane Doublet-Resistant Cells Generated by Hybridizing Single Resistant Cells

Background : Current standard chemotherapy for gynecologic malignancies consists of platinum agent and taxane though, many patients experience the relapse of disease with drug resistance making the following therapy unsuccessful. It’s a compelling question whether the mechanisms of doubly resistance is a simple combination of single agent resistance or whether the core novel mechanism common to platinum and taxane resistance stands out as a result of combination therapy. The purpose of this study is to establish the doublet drug resistant cell line and to find its genetic characteristics. Methods : Platinum/taxane doublet resistant cell lines (F3 and F4) were generated by hybridizing two independent, platinum or taxane resistant subline (C13 or PX24) stemmed from grand parental ME180 cells. The resistant cells were selected through repeated exposure to cisplatin and paclitaxel. For the assessment of drug sensitivity, colony forming assay was used. For the gene expression analysis, genome-wide expression profiling was done using the Human Genome U133A Array. Protein-protein interaction network (PPI) scaffold networks were retrieved from the Search Tool for the Retrieval of Interacting Genes database and, for the enrichment of pathway analysis, WebGestalt was used. Results : Colony forming assay showed C13 was 5.8-fold cisplatin resistant while PX24 was 5.3-fold paclitaxel resistant compared with parental ME180 cells. F3 and F4 acquired resistance to cisplatin and paclitaxel by 8.3/4.9- and 3.7/3.3-fold (F3/4) respectively. Microarray analysis demonstrated, out of 22284 genes, 103 genes were > 4-fold up-regulated in F3/4 and 33 (32%) were identified as simultaneously upregulated genes (SUG) in C13, PX24 and F3/4. The Protein-protein interaction analysis of 33 SUG displayed a scaffold network pivoting aldo-keto reductase 1C1 ( AKR1C1 ), aldo-keto reductase1C2 ( AKR1C2 ) and aldo-keto reductase1C3 ( AKR1C3 ). The enrichment pathway analysis demonstrated AKR1C gene family anchored to molecular function of oxidoreductase and aldo-keto reductase activity and biological process of daunorubicin and doxorubicin metabolism. Conclusions : We report here the establishment of doubly drug-resistant hybridoma to platinum and taxane. Analysis of SUG indicated the AKR1C gene family plays a key role for doubly resistant mechanism that would be possible targets for therapeutic strategies.
On nonlinearity implications and wind forcing in Hasselmann equation

We discuss several experimental and theoretical techniques historically used for Hasselmann equation wind input terms derivation. We show that recently developed ZRP technique in conjunction with high-frequency damping without spectral peak dissipation allows to reproduce more than a dozen of fetch-limited field experiments. Numerical simulation of the same Cauchy problem for different wind input terms has been performed to discuss nonlinearity implications as well as correspondence to theoretical predictions.
Radio pulsar activity and the crustal Hall drift

Models of pulsar radio emission that are based on an inner accelerating region require the existence of very strong and small scale surface magnetic field structures at or near the canonical polar cap. The aim of this paper is to identify a mechanism that creates such field structures and maintains them over a pulsar’s lifetime. The likely physical process that can create the required ’magnetic spots’ is the Hall drift occurring in the crust of a neutron star. It is demonstrated, that the Hall drift can produce small scale strong surface magnetic field anomalies (spots) on timescales of 10 4 years by means of non-linear interaction between poloidal and toroidal components of the subsurface magnetic field. These anomalies are characterized by strengths of about 10 14 G and curvature radii of field lines of about 10 6 cm, both of which are
Rabi spectroscopy of a qubit-fluctuator system

Superconducting qubits often show signatures of coherent coupling to microscopic two-level fluctuators (TLFs), which manifest themselves as avoided level crossings in spectroscopic data. In this work we study a phase qubit, in which we induce Rabi oscillations by resonant microwave driving. When the qubit is tuned close to the resonance with an individual TLF and the Rabi driving is strong enough (Rabi frequency of order of the qubit-TLF coupling), interesting four-level dynamics are observed. The experimental data show a clear asymmetry between biasing the qubit above or below the fluctuator's level splitting. Theoretical analysis indicates that this asymmetry is due to an effective coupling of the TLF to the external microwave field induced by the higher qubit levels.
Utilizing Frequent Pattern Mining for Solving Cold-Start Problem in Recommender Systems

Although several approaches have been proposed throughout the last decade to build recommender systems (RS), most of them suffer from the cold-start problem. This problem occurs when a new item hits the system or a new user signs up. It is generally recognized that the ability to handle cold users and items is one of the key success factors of any new recommender algorithm. This paper introduces a frequent pattern mining framework for recommender systems (FPRS) - a novel approach to address this challenging task. FPRS is a hybrid RS that incorporates collaborative and content-based recommendation algorithms and employs a frequent pattern (FP) growth algorithm. The article proposes several strategies to combine the generated frequent itemsets with content-based methods to mitigate the cold-start problem for both new users and new items. The performed empirical evaluation confirmed its usefulness. Furthermore, the developed solution can be easily combined with any other approach to build a recommender system and can be further extended to make up a complete and standalone RS.
Intercomparison of Landsat and Joint Polar Satellite System using Radiometric Calibration Network

Higher spatial and temporal resolution in Earth observation (EO) imagery is beneficial for many applications, including real-time hazard monitoring and agriculture. SI-traceable intercomparison between concurrent Earth imaging satellites can help harmonizing and improving spatial or temporal resolution of their data products. To that end, the Committee on Earth Observation Satellites (CEOS) initiated the Radiometric Calibration Network (RadCalNet) to provide automated surface and top-of-atmosphere TOA reflectance data from multiple participating ground sites to the worldwide user community. Here, we report results of the intercomparison between Landsat-8 Operational Land Imager (OLI) and National Oceanic and Atmospheric Administration-20 (NOAA-20) Visible Infrared Imaging Radiometer Suite (VIIRS) in the wavelength range from 400 nm to 2500 nm using RadCalNet as a common reference. The results of this study indicate that RadCalNet is a valuable tool for harmonization of EO imagery even in the case where the sensors have different temporal and spatial resolutions. Both OLI and VIIRS are calibrated to well-within their absolute radiometric calibration uncertainties and the two sensors agree with each other to better than 2% using RadCalNet sites as a common reference.
Quantum Multiplexers, Parrondo Games, and Proper Quantization

A quantum logic gate of particular interest to both electrical engineers and game theorists is the quantum multiplexer. This shared interest is due to the facts that an arbitrary quantum logic gate may be expressed, up to arbitrary accuracy, via a circuit consisting entirely of variations of the quantum multiplexer, and that certain one player games, the history dependent Parrondo games, can be quantized as games via a particular variation of the quantum multiplexer. However, to date all such quantizations have lacked a certain fundamental game theoretic property. The main result in this dissertation is the development of quantizations of history dependent quantum Parrondo games that satisfy this fundamental game theoretic property. Our approach also yeilds fresh insight as to what should be considered as the proper quantum analogue of a classical Markov process and gives the first game theoretic measures of multiplexer behavior.
Symplectic no-core shell-model approach to intermediate-mass nuclei

We present a microscopic description of nuclei in an intermediate-mass region, including the proximity to the proton drip line, based on a no-core shell model with a schematic many-nucleon long-range interaction with no parameter adjustments. The outcome confirms the essential role played by the symplectic symmetry to inform the interaction and the winnowing of shell-model spaces. We show that it is imperative that model spaces be expanded well beyond the current limits up through fifteen major shells to accommodate particle excitations that appear critical to highly-deformed spatial structures and the convergence of associated observables.
Computational optimization : a tribute to Olvi Mangasarian

Volume I. Guest Editorial J.-S. Pang. Solving Euclidean Distance Matrix Completion Problems Via Semidefinite Programming A.Y. Alfakih, et al. A Logarithmic-Quadratic Proximal Method for Variational Inequalities A. Auslender, et al. A Note on Error Bounds for Convex and Nonconvex Programs D.P. Bertsekas. Multicategory Classification by Support Vector Machines E.J. Bredensteiner, K.P. Bennett. Quartic Barriers R.W. Cottle. A Partitioned epsilon-Relaxation Algorithm for Separable Convex Network Flow Problems R. De Leone, et al. On a Primal-Dual Analystic Center Cutting Plane Method for Variational Inequalities M. Denault, J.-L. Goffin. A Shifted-Barrier Primal-Dual Algorithm Model for Linearly Constrained Optimization Problems G. Di Pillo, et al. Arithmetic Continuation of Regular Roots of Formal Parametric Polynomial Systems B.C. Eaves, U.G. Rothblum. Interfaces to PATH 3.0: Design, Implementation and Usage M.C. Ferris, T.S. Munson. Existence and Limiting Behavior of Trajectories Associated with Po-equations M.S. Gowda, M.A. Tawhid. Stabilized Sequential Quadratic Programming W.W. Hager. Volume II. Guest Editorial J.-S. Pang. The Clarke and Michel-Penot Subdifferentials of the Eigenvalues of a Symmetric Matrix J.-B. Hiriart-Urruty, A.S. Lewis. QPECgen, a MATLAB Generator for Mathematical Programs with Quadratic Objectives and Affine Variational Inequality Constraints H. Jiang, D. Ralph. Generalized Kojima-Functions and Lipschitz Stability of Critical Points D. Klatte, B. Kummer. On Extensions of the Frank-Wolfe Theorems Z. -Q. Luo, S. Zhang. Complementarity Constraint Qualifications and Simplified B-Stationarity Conditions for Mathematical Programs with Equilibrium Constraints J.-S. Pang, M. Fukushima. First-Order Algorithms for Generalized Semi-Infinite Min-Max Problems E. Polak, et al. An Optimal Way of Moving a Sequence of Points onto a Curve in Two Dimensions M.J.D. Powell. Some Optimization Reformulations of the Extended Linear Complementarity Problem M.V. Solodov. On NCP-Functions D. Sun, L. Qi. Convergence and Error Bound for Perturbation of Linear Programs P. Tseng. An Interior-Point Algorithm for Nonconvex Nonlinear Programming R.J. Vanderbei, D.F. Shanno. Testing Parallel Variable Transformation E. Yamakawa, M. Fukushima.
A Millimeter-Wave Spoof-Surface-Plasmon-Polaritons-Fed Dual-Polarized Microstrip Patch Antenna Array

A novel millimeter-wave spoof surface plasmon polaritons (SSPPs)-fed dual-polarized microstrip patch antenna array is proposed in this article. A dual-polarized single-layered square patch antenna fed by SSPPs is investigated first acting as the radiators. A method of directly connecting two orthogonal SSPPs with two edges of the square patch is introduced to excite the TM10 and TM01 modes and to achieve promising performance simultaneously. The fabricated antenna element has a measured overlapped impedance bandwidth of 13.7%, an isolation of more than 15 dB between the two inputs, a gain of up to about 6 dBi, and stable dual-polarized radiation patterns. With the use of two SSPPs branches printed on different sides of the substrate, a compact SSPPs power divider with adjustable power dividing ratio is then investigated for realizing the series SSPPs feed network, whose design considerations are discussed in detail. By combining the feed network with the patch elements, a $1\times $ 4 SSPPs-fed dual-polarized microstrip patch antenna array is fulfilled. The fabricated prototype confirms a bandwidth of 15% and dual-polarized broadside radiations. Benefitted from the simple single-layered geometry without the metallic ground plane over the major region of array geometry and the dual-polarized unidirectional radiation, the presented designs are valuable to emerging millimeter-wave applications.
Weighted Metric Multidimensional Scaling

This paper establishes a general framework for metric scaling of any distance measure between individuals based on a rectangular individuals-by-variables data matrix. The method allows visualization of both individuals and variables as well as preserving all the good properties of principal axis methods such as principal components and correspondence analysis, based on the singular-value decomposition, including the decomposition of variance into components along principal axes which provide the numerical diagnostics known as contributions. The idea is inspired from the chi-square distance in correspondence analysis which weights each coordinate by an amount calculated from the margins of the data table. In weighted metric multidimensional scaling (WMDS) we allow these weights to be unknown parameters which are estimated from the data to maximize the fit to the original distances. Once this extra weight-estimation step is accomplished, the procedure follows the classical path in decomposing a matrix and displaying its rows and columns in biplots.