Miracle-dz/UniFAR-FTUs huggingface dataset:
ENDOTHELIUM-SPECIFIC DEFICIENCY OF POLYCYSTIN-1 PROMOTES HYPERTENSION AND CARDIOVASCULAR DISORDERS

Objective: Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent hereditary kidney disease and is generally due to mutations in PKD1 and PKD2, encoding polycystins 1 and 2. In ADPKD, hypertension and cardiovascular (CV) disorders are highly prevalent but their mechanisms are partially understood. The objective of this study was to determine whether hypertension and the CV disorders of ADPKD are a consequence of the endothelial deficiency in the polycystin complex, rather than to the kidney disease, as is currently believed. Design and method: Since endothelial cells express the polycystin complex, where it plays a central role in the mechanotransduction of blood flow, we generated a murine model with inducible deletion of Pkd1 in endothelial cells (Cdh5-CreERT2;Pkd1fl/fl) to specifically determine the role of endothelial polycystin-1 in ADPKD. We nalysed the endothelial phenotype associated with Pkd1 deficiency, invasive and non-invasive blood pressure, vascular function on isolated vessels, and echocardiography. The impact on the development of a model of aorto-cava arterio-venous fistula and on the CV consequences of superimposed chronic kidney disease were nalysed to further establish the clinical relevance of our results. Results: As expected, transgenic mice presented normal kidney structure and function. Endothelial deletion of Pkd1 induced endothelial dysfunction, as demonstrated by impaired flow-mediated dilatation of resistance arteries and impaired relaxation to acetylcholine, increased blood pressure and prevented the normal development of arterio-venous fistula. In experimental chronic kidney disease induced by subtotal nephrectomy, endothelial deletion of Pkd1 further aggravated endothelial dysfunction, vascular remodelling and heart hypertrophy. Conclusions: Altogether, this study provides the first in vivo demonstration that specific deletion of Pkd1 in endothelial cells promotes endothelial dysfunction and hypertension independently of kidney cysts and of impaired kidney function, impairs arterio-venous fistula development and potentiates the cardiovascular alterations associated with chronic kidney disease. It establishes the endothelium as a significant contributor to cardiovascular disease in ADPKD.
Application of partial proportional odds model for analyzing pedestrian crash injury severities in Switzerland

ABSTRACT According to the Swiss Microcensus, Switzerland is a place where people choose to walk more than 40% of their daily trip time, resulting in a higher pedestrian crash to total crash ratio when compared to many other developed countries. Furthermore, the high number of old and young pedestrians as well as the large number of pedestrian crashes with higher levels of severity makes the pedestrian crash analysis for Switzerland very important. This study aims to identify the important factors that influence the injury severity levels of pedestrian–vehicle crashes in Switzerland. To address this we employ a partial proportional odds model to analyze pedestrian crash injury severities in Switzerland, based on the 5-year (2008–2012) pedestrian safety data. The study also focuses on a separate analysis for two vulnerable groups of pedestrians (young and old pedestrians) to examine the change in the influence of factors over age. The analysis involves an extensive evaluation based on pedestrian and driver characteristics; main reason for the crash; traffic, temporal, vehicle, roadway geometric and environmental characteristics. The study shows that irrespective of age, dark unlighted areas, sight obstructions, midblock crossings and heavy vehicles adversely affect the injury severity levels of pedestrians.
Simple predictive score for nocturnal hypertension and masked nocturnal hypertension using home blood pressure monitoring in clinical practice

Objective: The decision whether to measure night-time blood pressure (BP) is challenging as these values cannot be easily evaluated because of problems with measurement devices and related stress. Using the nationwide, practice-based Japan Morning Surge-Home BP Nocturnal BP study data, we developed a simple predictive score that physicians can use to diagnose nocturnal hypertension. Methods: We divided 2765 outpatients (mean age 63 years; hypertensive patients 92%) with cardiovascular risks who underwent morning, evening, and night-time home BP (HBP) measurements (0200, 0300, and 0400 h) into a calibration group (n = 2212) and validation group (n = 553). We used logistic-regression models in the calibration group to identify the predictive score for nocturnal hypertension (night-time HBP ≥120/70 mmHg) and then evaluated the score's predictive ability in the validation group. Results: In the logistic-regression model, male sex, increased BMI) (≥25 kg/m2), diabetes, elevated urine-albumin creatinine ratio (UACR) (≥30 mg/g Cr), elevated office BP (≥140/90 mmHg) and home (average of morning and evening) BP (≥135/85 mmHg) had positive relationships with nocturnal hypertension. The predictive scores for nocturnal hypertension were 1 point (male, BMI, and UACR); 2 points (diabetes); 3 points (office BP ≥140/90 mmHg); 6 points (home BP ≥135/85 mmHg); total 14 points. Over 75% of the nocturnal hypertension cases in the validation group showed at least 10 points [AUC 0.691, 95% CI (0.647–0.735)]. We also developed a score for masked nocturnal hypertension, that is, nocturnal hypertension despite controlled daytime HBP. Conclusion: We developed a simple predictive score for nocturnal hypertension that can be used in clinical settings and for diagnoses.
Variety of Immunoglobulin G Functions

The diversity of immunoglobulin (Ig) functions may be explained by the peculiar structure of these flexible molecules. Heavy and light Ig chains are composed from compact stable immunoglobulin folds (IgF), or domains belonging to a large protein super family. Proteins composed from IgF have been found in various representatives of animal kingdom even those appeared during the very early stages of evolution [1,2]. Such evolutionary conservation supports the well-known fact that useful structural elements appeared early in evolution later preserved and long-lived. The most important feature of IgF lies in its specific ability to bind molecules of various chemical structures and dimensions from large proteins to small molecules such as peptides and simple carbohydrates. First of Ig interactions are related to the formation of immune complexes (IC) of antibody molecules with antigens at antigen-combining sites. Igs are able to form non-IC with various proteins on sites located on only one domain, or on sites composed from residues on different domains [3,4]. Therefore, IgF acts as a scaffold on which arrays of binding sites are displayed on β strands or on those parts on Ig peptide chains that are connected the strands. One aspect of the Ig interactions outside the antigen binding sites with the formation of non-IC is most important for adaptive immune processes while others aspects are involved in some other functions.
Comparison of different time-frequency analysis tools in a Slug Flow based on Slug Tracking model

The aim of this work is to compare different time frequency analysis tools in a slug flow. The slug flow is the succession of long gas bubbles which are neither periodic in time nor in frequency. Experimental data mixed with Slug Tracking model, which is an analytical approach, are employed in order to obtain its time variant natural frequencies. The applicability of the Short Time Fourier Transform, Wavelet Transform, Wigner-Ville Distribution and Hilbert- Huang Transform are compared and discussed aiming at discussing advantages and disadvantages of each method in the analysis of the time variant behavior of the bubble natural frequency.
A Survey on MQTT Protocol for the Internet of Things

— It has been more than fifteen years since the term Internet of Things (IoT) was introduced to the public. However, despite the efforts of research groups and innovative corporations, still today it is not possible to say that IoT is upon us . This is mainly due to the fact that a unified IoT architecture has not been yet clearly defined and there is no common agreement in defining protocols and standards for all IoT parts. The necessity to accommodate hundreds and thousands of sensors for successful automation is of great prominence in the field of M2M communication with increasing appliances at home and industries,. MQTT or Message Queue Telemetry Transport is an Internet of Things protocol for machine to machine communication. The protocols MQTT capable of handling sensor traffic under low bandwidth and constrained network conditions are extensively used to improve automated systems. MQTT protocol with an intensive use of Internet of things (IoT) environment which guarantees the following properties within the automation process: Advanced reports and statistics, remote command execution on one or more units (groups of units), detailed monitoring of remote units and custom alarm mechanism and firmware upgrade on one or more units (groups of units). MQTT is designed for small devices that don’t have much memory or processing power and for low-bandwidth, high-cost, and unreliable networks. It’s designed to minimize network bandwidth and device resource requirements while providing the required assurance of delivery.
Full Title: THE INFLUENCE OF CAREGIVER ATTITUDES AND SOCIO-ECONOMIC

This is an Open Access article, distributed under the terms of the Creative Commons AttributionNonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work. TITLE PAGE 1 2 Full Title: THE INFLUENCE OF CAREGIVER ATTITUDES AND SOCIO-ECONOMIC 3 GROUP ON FORMAL AND INFORMAL MENTAL HEALTH SERVICE USE AMONGST 4 YOUTH 5 6 Shorten Title (running head): FORMAL AND INFORMAL MENTAL HEALTH SERVICE 7 USE AMONGST YOUTH 8 9 10 11 Authors and affiliations 12 13 Cristiane Silvestre Paula, Ms, PhD 14 Paula CS 15 Programa de Pós-Graduação em Distúrbios do Desenvolvimento e Centro Mackenzie de Pesquisa 16 sobre a Infância e AdolescênciaUniversidade Presbiteriana Mackenzie (UPM), São Paulo-SP, 17 Brazil 18 ORCID: 0000-0003-0438-9407 19 Email address: cristiane.paula@mackenzie.br 20 csilvestrep09@gmail.com 21 Disclosure: Nothing to declare 22 23 Carolina Ziebold, Ms, PhD 24 Ziebold C 25 Departamento de Psiquiatria – Universidade Federal de São Paulo (UNIFESP), São Paulo-SP, 26 Brazil 27 ORCID: 0000-0002-7965-6680 28 Email address: carolaziebold@gmail.com 29 Disclosure: Nothing to declare 30 31 Wagner S Ribeiro, PhD. 32 Ribeiro WS 33 Care Policy and Evaluation Centre, London School of Economics and Political Science 34 -LSE 35
Microsoft Word-Rev_SKpaper_TC_100312 copy.docx

Capsule: Background. GAS virulence is dependent on a functional human fibrinolytic system. Results. Functional differences between different strains of GAS streptokinases have been found. Conclusion. Pressure on coinheritance of specific GAS streptokinases and M-proteins is identifiable. Significance. Tissue tropism and virulence of GAS infections are reflected in the types of streptokinases and M-proteins. http://www.jbc. org/cgi/doi/10.1074/jbc.M112.417808 The latest version is at JBC Papers in Press. Published on October 18, 2012 as Manuscript M112.417808
ABORTION IN PHOTOGRAPHS IN CHILEAN DIGITAL MEDIA:

In September 2017, the Chilean government passed a bill decriminalizing abortion under three circumstances. The Parliament took three years in discussing the reform and the media (re)produced a debate feed by feminist and human rights organizations, pro-life and pro-choice activists, and political players, and congressmen and presidential representatives. This article thematically analyzes the photographs published in ten Chilean online outlets throughout a year. We organized the images into categories in attempt to understand the role that photographs have in influencing public opinion, constituting ideal audiences. Relying upon the material analyzed, we concluded that the images are not neutral, but create truthfulness, and contribute to establishing a social memory that reinforces patriarchal order, which is hegemonic in the national imaginary.
Comparison of the Sit-to-Stand and Stand-to-Sit Activities between Patients with COPD and Healthy Subjects: A Pilot Study

Subjects with Chronic Obstructive Pulmonary Disease (COPD) usually present muscle weakness as an extra-pulmonary consequence of the disease, which can impair physical function. Our goal was to investigate the Sit-to-Stand and Stand-to-Sit (STSTS) performance in individuals with COPD compared with healthy subjects. A pilot study was conducted on 25 patients with COPD and 27 healthy adults. Videos of the STSTS activities were recorded on Anterior View (AV) and Lateral View (LV). The STSTS activities were compared between groups through an Expert System (ES) according to an evaluation protocol with a classification score from 0 (adequate condition) to 4 (inadequate condition level IV). Data analyses were performed with Statistical Package for the Social Sciences (SPSS) 22.0 version. A p value of <0.05 was considered significant. There were significant differences in the STSTS activities in both views between both groups (Stand-to-Sit AV, p=0.000; Stand-to-Sit LV p=0.001; Sit-to-Stand AV, p=0.000; Sit-to-Stand LV, p=0.000). COPD patients presented the worse scores (median) in the Stand-to-Sit activities (2.44 AV; 2.28 LV). Individuals with COPD showed worse functional condition compared to healthy subjects, especially in the Stand-to-Sit activity.
The environmental sustainability of the Dutch diet : Background report to 'What is on our plate? Safe, healthy and sustainable diets in the Netherlands

De productie en consumptie van voedsel legt een grote druk op het milieu. Dit komt onder andere door intensief gebruik van landbouwgrond en door de uitstoot van broeikasgassen bij de productie van voedsel. Ons dagelijks eten heeft dus grote invloed op het milieu. Wereldwijd is de voedselproductie en -consumptie verantwoordelijk voor ongeveer 25 procent van de totale uitstoot van broeikasgassen. Daarnaast is deze voor 60 procent verantwoordelijk voor het verlies aan de variatie van gewassen en dieren (biodiversiteit). Het RIVM heeft in dat verband beschreven hoe en in welke mate de productie voor de huidige Nederlandse voedselconsumptie een belasting voor het milieu vormt. Daaruit blijkt dat vlees, zuivel (inclusief kaas) en dranken het meest belastend zijn. Voor de meeste voedingsmiddelen zit dat vooral in de productiefase. Zo is veel land en water nodig om vlees- en zuivel te produceren. Ook zorgen deze producten voor de meeste verzuring/vermesting van de bodem en het oppervlaktewater. Voor de productie van fruit is relatief veel water nodig. Hoewel het primaire productieproces van de meeste voedingsmiddelen de grootste milieudruk veroorzaakt, is ook het gebruik van fossiele energie en grondstoffen voor het verpakken, transporteren, bewaren en bereiden van producten relevant; in welke mate verschilt per product. In dit rapport wordt de milieubelasting van ons voedingspatroon meer in detail beschreven. De milieubelasting kan worden verminderd door (technologische) innovaties die per voedingsmiddel de uitstoot van ongewenste emissies verlagen en/of overmatig gebruik van natuurlijke hulpbronnen verkleinen. Minder voedsel verspillen en niet teveel eten en drinken zorgen ook voor minder milieubelasting. De consument kan daarnaast een bijdrage leveren met zijn keuze voor bepaalde voedingsmiddelen, zoals minder vaak vlees en vaker kraanwater in plaats van frisdrank en alcohol. Dit rapport is een achtergrondstudie voor de rapportage 'Wat ligt er op ons bord? Gezond, veilig en duurzaam eten in Nederland' van het RIVM die op 24 januari 2017 is verschenen. Hierin worden de aspecten van gezond, veilig en ecologisch duurzaam voedsel geintegreerd weergegeven.
RECENT DEVELGPMENTS IN MODELING VOLATILITY IN FINANCIAL DATA ~) T.E. NIJMAN AND F.C. PALM

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Total volume evaluation of high-power density non-isolated DC-DC converters with integrated magnetics for electric vehicles

One of the main problems in electric vehicles is the volume of their electrical systems because their bulky components carry additional mass and high cost to the total system. On this topic, interleaving-phases and magnetic coupling techniques have been reported as effective methods for increasing the power density of the DC–DC converters that work between the storage unit and the motor inverter. In that sense, a volume assessment of these topologies would provide a better understanding of the problems to be faced when an electric power train is designed. In this paper, a volume modelling methodology is introduced with the purpose of comparing four different DC–DC converters: Single-Phase Boost, Two-Phase Interleaved with non-coupled inductors, Loosely Coupled Inductor (LCI), and Integrated Winding Coupled Inductor (IWCI). The analysis considers the volume of magnetic components, power devices (conventional and next-generation), cooling devices and capacitors. The methodology can be used as a part of an optimization procedure to minimize the volume of DC–DC converters. Conclusively, LCI and IWCI were found effective to miniaturize power converters with a power density of 8.4 W/cc and 9.66 W/cc, respectively. Moreover, a maximum efficiency of 98.04% and 97.61% was obtained for a 1kW LCI and IWCI prototypes, respectively.
Tetragenococcus halophilus Alleviates Intestinal Inflammation in Mice by Altering Gut Microbiota and Regulating Dendritic Cell Activation via CD83

Ulcerative colitis (UC) is one of the major subtypes of inflammatory bowel disease with unknown etiology. Probiotics have recently been introduced as a treatment for UC. Tetragenococcus halophilus (T. halophilus) is a lactic acid-producing bacterium that survives in environments with high salt concentrations, though little is known about its immunomodulatory function as a probiotic. The purpose of this study is to determine whether T. halophilus exerts an anti-inflammatory effect on intestinal inflammation in mice. Colitis was induced in C57BL/6J mice by feeding 4% DSS in drinking water for 7 days. T. halophilus was orally administered with DSS. Anti-inflammatory functions were subsequently evaluated by flow cytometry, qRT-PCT, and ELISA. Gut microbial composition was analyzed by 16S rRNA metagenomic analysis. DSS-induced colitis mice treated with T. halophilus showed less weight loss and significantly suppressed colonic shortening compared to DSS-induced colitis mice. T. halophilus significantly reduced the frequency of the dendritic cell activation molecule CD83 in peripheral blood leukocytes and intestinal epithelial lymphocytes. Frequencies of CD8+NK1.1+ cells decreased in mice with colitis after T. halophilus treatment and IL-1β levels were also reduced. Alteration of gut microbiota was observed in mice with colitis after administration of T. halophilus. These results suggest T. halophilus is effective in alleviating DSS-induced colitis in mice by altering immune regulation and gut microbiome compositions.
Genome-Wide Analysis of Genes Involved in the GA Signal Transduction Pathway in ‘duli’ Pear (Pyrus betulifolia Bunge)

Gibberellic acid (GA) is an important phytohormone that regulates every aspect of plant growth and development. While elements involved in GA signaling have been identified and, hence, their functions have been well studied in model plants, such as Arabidopsis and rice, very little is known in pear. We, therefore, analyzed the genes related to GA signaling from the recently sequenced genome of the wildtype ‘duli’ pear (Pyrus betulifolia Bunge), a widely used rootstock for grafting in pear cultivation in China due to its vigorous growth and resistance to abiotic and biotic stress. In total, 15 genes were identified, including five GA receptors PbGID1s (GA-INSENSTIVE DWARF 1), six GA negative regulators, PbDELLAs, and four GA positive regulators, PbSLYs. Exogenous application of GA could promote the expression of PbGID1s but inhibit that of PbDELLAs and PbSLYs in tissue culture ‘duli’ pear seedlings. The expression profiles of these genes in field-grown trees under normal growth conditions, as well as in tissue-cultured seedlings treated with auxin (IAA), GA, paclobutrazol (PAC), abscisic acid (ABA), and sodium chloride (NaCl), were also studied, providing further evidence of the involvement of these genes in GA signaling in ‘duli’ pear plants. The preliminary results obtained in this report lay a good foundation for future research into GA signaling pathways in pear. Importantly, the identification and preliminary functional verification of these genes could guide molecular breeding in order to obtain the highly desired dwarf pear rootstocks for high-density plantation to aid easy orchard management and high yielding of pear fruits.
MILLET (BRASSICA NAPUS L.) ROTATION MODEL PROMOTED THE YIELD OF MILLET BY IMPROVING THE FUNGAL COMMUNITY STRUCTURE IN DRYLANDS IN CHINA

Plant-crop rotation model plays an important regulatory role in effectively avoiding the occurrence of continuous cropping obstacles in drylands. However, it is not clear how fungal communities change in soils with some different rotation models. To solve this question, we determined the soil nutrient contents, and compared the composition of fungi from soils (0-20 cm) using fungal ITS pyrosequencing techniques. We also tested different crop rotation regimes, including Triticum aestivum L. and millet rotation (TaSi), small rye (Triticale Secalotriticum) and millet rotation (TsSi), one season of leisure (no any crop) and one season of millet (Si), rape (Brassica napus L.) and millet rotation (BnSi). The results showed that BnSi significantly improved soil available potassium contents, the activity of soil catalase, and yields of Setaria italica, while reduced soil Alkali-hydrolyzed nitrogen contents compared with other three groups. Fungal alpha-diversity index in BnSi was the highest. The relative abundances of Ascomycota in BnSi (61.53%) and TsSi (62.6%) were higher than that in Si (58.65) and TaSi (55.67%), while Basidiomycota exhibited the opposite trend. Available potassium and organic matter were significant factors affecting fungal communities, explaining 61.4% of total variation. Our findings shed new light on the response of the soil fungal communities to long-term green manure regimes.