Miracle-dz/UniFAR-FTUs huggingface dataset:
Stress granule formation mediates the inhibition of colonic Hsp70 translation by interferon- (cid:1) and tumor necrosis factor- (cid:2)

Stress granule formation mediates the inhibition of colonic Hsp70 translation by interferon- (cid:1) and tumor necrosis factor- (cid:2) . Am J Physiol Gastrointest Liver Physiol G481–G492, inﬂammation, through cytokines such as interferon- (cid:1) (IFN- (cid:1) ) and tumor necrosis factor- (cid:2) (TNF- (cid:2) ), has many effects on the intestinal epithelium, including selective translational inhibition of the cytoprotective protein heat shock protein 70 (Hsp70). To further elucidate the mechanisms underlying this effect, we examined the role of stress granules in mediating the actions of these proinﬂammatory cytokines. Using conditionally immortalized young adult mouse colonic epithelial cells, we demonstrate that IFN- (cid:1) and TNF- (cid:2) , which upregulate eukaryotic initiation factor- (cid:2) (eIF-2 (cid:2) ) phosphorylation and reduce Hsp70 translation, signif-icantly enhance stress granule formation in heat-shocked intestinal epithelial cells. The IFN- (cid:1) and TNF- (cid:2) effects in upregulation of stress granule formation and downregulation of Hsp70 were eIF-2 (cid:2) dependent, and the effect could be negated by blocking eIF-2 (cid:2) phosphorylation with use of an RNA-dependent protein kinase inhibitor. Correspondingly, IFN- (cid:1) and TNF- (cid:2) increased binding of cytoplasmic proteins to the 3 = -untranslated region of Hsp70 mRNA, suggesting speciﬁc recruitment of Hsp70 to stress granules as the mechanism of IFN- (cid:1) and TNF- (cid:2) inhibition of Hsp70 translation. We thus report a novel linkage between inﬂammatory cytokine production, stress granule formation, and Hsp70 translation inhibition, providing additional insights into the response of intestinal epithelial cells to inﬂammatory stress. (cid:1) andTNF- (cid:2) ,inadditiontoheatstress leads to stress granule formation in almost every cell, thus signiﬁcantly sequestering Hsp70 mRNA in an untranslated state. IFN- (cid:1) and TNF- (cid:2) leads to phosphorylation of eIF-2a by enhanced phosphorylation of PKR, an action that can be blocked by PKR-I. IFN- (cid:1) and TNF- (cid:2) also promote the relocation of RNA-binding proteins, like TIA-1, from the nucleus to the cytoplasm, which further enhances the stress granule assembly.
Event Based Energy Efficient Routing Protocol for Wireless Sensor Networks (WSNs)

--Sensor nodes that are deployed in the wireless sensor field are equipped with limited energy power. The most important problem in the wireless sensor network is to develop the energy efficient, reliable and robust routing protocol. To achieve these targets, we have proposed a new Event-based Energy Efficient Routing Protocol (EBEERP). EBEERP is also concerned to the reliable data dissemination in the wireless sensor network. In this protocol, we have used the Tier based architecture for data dissemination among the sensor nodes. We have simulated the results of our protocol with LEACH and PEGASIS and observed that it is 7.5 times better than LEACH and 2 times better than PEGASIS.
Generation of epidermal growth factor and green fluorescent protein coexpressing Lactobacillus acidophilus and its effect on intestinal histology improvement in mature LPS-challenged mice

The aim of the present study was to construct a recombinant strain by using the probiotics Lactobacillus acidophilus expressing the epidermal growth factor (EGF), which can improve intestinal morphology, and to test its effect on the intestinal histology in LPS (lipopolysaccharide)-challenged mice. The EGF gene was cloned into the shuttle vector pSET4s and then transformed into the L. acidophilus MG6243 strain by electroporation. Two recombinant strains were confirmed by SDS-PAGE and named ΔMG6243-1 and ΔMG6243-2. Sixty mice were randomly assigned to six treatments: 1) non-challenged control, 2) LPS-challenged control, 3) LPS-challenged + 200 μl MG6243, 4) LPS-challenged + 200 μl ΔMG6243-1, 5) LPS-challenged + 200 μl ΔMG6243-1 + inducer IPTG, and 6) LPS-challenged + 200 μl ΔMG6243-2. There were ten replicates for each treatment, and each replicate had one mouse. On d 15, the LPS-challenged mice were injected intraperitoneally with LPS at 10 mg/kg BW, while the non-challenged mice were injected with 0.9% NaCl solution. Three hours after the challenge, all mice were killed. Results showed that both ΔMG6243-1 and ΔMG6243-2 could increase villus height in the duodenum, ileum and jejunum (P<0.05). In addition, the recombinant L. acidophilus decreased the crypt depth in the duodenum and ileum (P<0.05). These results indicated that the recombinant L. acidophilus could effectively improve the intestinal histology in LPS-challenged mice.
Effect of concurrent intramuscular administration of Meloxicam on the Pharmacokinetics of Cefquinome in Goats and Effect of concurrent administration on the in Goats.

The deposition kinetics of Cefquinome (2mg/kg) was studied following intramuscular administration of it alone and co-administered with meloxicam (0.2 mg/kg) in goats. The concentration of Cefquinome in serum was detected by HPLC. Following single dose intramuscular administration of Cefquinome alone, peak plasma concentration (1.71±0.0189μg/mL) was obtained at 1.59±0.0038 h. The absorption half-life (t 1/2ab ), total body clearance (Cl tot ), elimination half-life (t 1/2el ) and area under curve (AUC (0-inf) ) of Cefquinome were 0.4±0.0028h, 0.068±0.78L/h/kg, 9.21±0.178 h and 29.36±0. 78µg. h.ml -1 , respectively. No significant changes were reported in the pharmacokinetic parameters following co-administration of Cefquinome with meloxicam. Following single dose intramuscular coadministration of Cefquinome and meloxicam, peak plasma concentration (1.60±0.0124μg/mL) was obtained at 1.49±0.0092h. The absorption half-life (t 1/2ab ), total body clearance (Cl tot ), elimination half-life (t 1/2el ) and area under curve (AUC (0-inf) ) of Cefquinome were 0.396±0.006 h, 0.094±0.25 L/h/kg, 6.5±0.221hand 21.38±0. 696µg. h.ml -1 , respectively. From our results, may be concluded that intramuscular administration of meloxicam (0.2 mg/kg) may be successfully co-administrated with Cefquinome (2 mg/kg) for combating bacterial infections with an inflammatory condition in goats without any antagonistic effect.
DETECTION THRESHOLDS IN AUDIO-VISUAL REDIRECTED WALKING

Redirected walking is a technique that enables users to explore a walkable virtual environment that is larger than the extent of the available physical space by manipulating the users’ movements. For the proper application of this technique, it is necessary to determine the detection thresholds for the applied manipulations. In this paper an experiment to measure the detection levels of redirected walking manipulations in an audio-visual virtual environment is described and the re-sults are presented and compared to previous results of a purely acoustically controlled redirected walking experiment.
Poacher Detection using YOLO Algorithm

—Illegal trade of wild animals is a merciless offence as various species of animals like elephants, rhinos and tigers are being killed for their valuable possessions like ivory, horn, skin, etc. The forest rangers conduct patrols with the aim of preventing poaching activities that are killed by poachers. Hence, the task is automated. Yolo algorithm which is currently state-of-the-art algorithm can be used to locate these poachers from a distant place. Also, it is comparatively faster than its competitors and hence better option for detection of poachers.
Destruction Testing: Ultra-Low Delay using Dual Queue Coupled Active Queue Management

Large queues on the Internet are traditionally needed to provide high utilization of network traffic, however it comes at the cost of high delay. DualPI2 is an Active Queue Management (AQM) proposal which attempts to allow scalable TCP traffic to co-exist with traditional TCP, allowing both high utilization and low delay. This thesis presents a test framework that can be used to evaluate AQMs and congestion controls, being capable of simulating a full testbed on a single machine. The test framework is used to evaluate DualPI2 trying to find areas where it might break and need improvements. I find that the test framework is very useful in investigating and analyzing the behaviour of DualPI2, and that there are still some scenarios that should be considered for improvements.
Fog Computing: Concepts, Principles and Related Technologies

: Fog Computing, sometimes also referred to as Edge Computing, extends the Cloud Computing paradigm to lower latency, improve location awareness, provide better support for mobility and increase business agility. There is necessarily a requirement for these attributes in this age of Internet of Things (IoT) where, according to one estimate, there will be close to 50 billion interconnected smart devices by 2020 and the amount of Big Data generated by these devices is expected to grow to around 200 exabytes per year by 2020. The core characteristic of the Fog Computing architecture is that it provides compute and data analytics services more immediately and close to the physical devices that generate such data, ie at the Edge of the network, and thus bypassing the wider Internet. In this chapter, we discuss the Fog paradigm, its concepts, principles, present the difference between the Cloud and Fog architectures, and briefly discuss the OpenFog Reference Architecture. Hopefully, this chapter will set a scene for the various Fog-related topics presented in the rest of this book.
Relationship Between Physical Performance and Mild Cognitive Impairment in Chinese Community-Dwelling Older Adults

Objective: This study aimed to examine the relationship between physical performance and mild cognitive impairment (MCI) in Chinese older adults. Methods: The sample comprised 956 relatively healthy and aged ≥65 years old Chinese community-dwelling participants (mean age, 72.56 ± 5.43 years; 56.8% female), which did not include those with dementia, severe cognitive impairment, mental illness etc. The Mini-Mental State Examination (MMSE) and the Instrumental Activities of Daily Living (IADL) scale were used for the initial classification of patients with MCI. Physical performance was measured via hand grip, Timed Up and Go Test (TUGT), and 4-m walking speed. Results: The physical performance (grip strength, TUGT, and 4-m walking speed) correlated with MCI. The grip strength [odds ratio (OR) = 0.96, 95% confidence interval (CI) = 0.93–0.99] and 4-m walking speed (OR = 0.25, 95% CI = 0.10–0.64) correlated negatively with MCI, while TUGT (OR = 1.08, 95% CI = 1.03–1.13) and MCI correlated positively. Conclusion: The physical performance (grip strength, TUGT, and 4-m walking speed) correlated with MCI. Further analysis showed that the grip strength was associated with overall cognition, time orientation, recall, and language, while TUGT and 4-m walking speed were associated with overall cognition and various cognitive domains, except recall.
PGPM_A_319308 1211..1220

1Department of Pharmacy, Harbin Medical University Cancer Hospital, Harbin, People’s Republic of China; 2Cancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI, USA; 3Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, HI, USA; 4Laboratory of Glycogenomics, Institute of Cytology and Genetics, Novosibirsk, Russia
LINGUISTIC CAPACITY OF VERY YOUNG CHILDREN. BY BEVER, THOMAS G. AND OTHERS

Basic linguistic capacity is pres&it extremely early in children. Two-yearolds understand transitive active sentences, three-year-olds understand many passive sentences. Older children understand some sentences less well than younger children. This brief decrease in comprehension ability is due to the temporary overgeneralization of perceptual strategies which are drawn from the
Application of Convolutional Neural Network and Deep Learning for Detection of Cardiac Arrhythmia Heart Disease

The goal of this paper is apply convolutional neural networks to Electrocardiogram signals to detect cardiac arrhythmia, which is a form of heart diseases. The new high-tech Electrocardiogram sensors and other medical devices have significantly improved the quantity and quality of Electrocardiogram recordings in high volume. Futhermore, the availability of high computing GPUs have made it easy to process large amout of data in a short amount of time. We have developed a method for Electrocardiogram arrhythmia classification which converts Electrocardiogram signals to two dimentional images to be processed with convolutional neural networks, which is a form of deep machine learning. Deep learning has been proven to be an effective means for complex data analysis with minimal pre-and post-processing requirement. It is the primary tool in this research. We use the proposed convolutional neural networks architecture for classifying cardica arrhythmia into three distinct categories: normal sinus rhythm, paced rhythm, and other rhythm. The Electrocardiogram signal is converted into a two-dimensional grayscale image and used as an input data for the convolutional neural networks classifier. We use various deep learning techniques such as batch normalization, data augmentation, and averaging-based feature aggregation across time. We use several image crop techniques for data augmentation and K fold cross validation for overcoming over-fitting. The proposed classifier can reach a classification accuracy of over 95% on the data we acquired from PhysioNet/CinC Challenge 2017
MULTIPLE SCLEROSIS EPIDEMIOLOGY IN ARABIAN GULF REGION: A SYSTEMATIC REVIEW

: Background: Multiple sclerosis (MS) is a chronic inflammatory multifocal demyelinating disease of the central nervous system (CNS) with progressive neurodegeneration. MS is one of the world's most common neurologic disorders and consider to be the most common cause of non-traumatic disability in young adults. According to Atlas multiple sclerosis of WHO, the median estimated prevalence and incidence of MS is greatest in Europe followed by the Eastern Mediterranean, the Americas, the Western Pacific, South-East Asia and Africa. The Arabian Gulf Region is located in a low-risk zone for MS; however, recent studies suggest a moderate-to-high prevalence nearby. Objective: In our review we aim to describe and compare demographic and clinical characteristics of MS in Arabian gulf countries (AGCs). Methods: PubMed database were used for articles selection. All relevant articles related to our review were chosen to cover the following topics: Multiple sclerosis, epidemiology, prevalence, incidence. We excluded other articles, which are not related to our objectives. The data have been extracted according to specific form to be reviewed by the authors Results and discussion: We enrolled a total of 13 studies according to our inclusion, and exclusion criteria. McDonald's criteria were the most widely used diagnostic criteria in the studies. Most studies were conducted in single hospital-based centers with a defined catchment area. The female/male ratio ranged from 1.1 in Oman to 4.3 in Saudi Arabia. The mean age at disease onset ranged from 25.2 years Kuwait to 32 years Saudi Arabia. MS prevalence ranged from 85.05/100,000 in 2013 to 4/100000 in 2000 reported in Kuwait and Oman respectively. Conclusion: There is an increase in the prevalence and incidence that were reported in some AGCs such as Kuwait over the years. However, the prevalence and incidence of MS overall in are not well-documented in many countries of Arabian Gulf Region.
Long Distance Transport in Macrocystis integrifolia I. TRANSLOCATION OF 14C-LABELED ASSIMILATES'

Long distance transport of '4C-labeled photoassimilate was studied in Macrocystis ixtegrifolia Bory. Movement of label folowed the source-sink relationship; mature blades closer to the hoWdfast with young 20 and 30 fronds transported mostly to the base, those closer to the frond apex transported mostly to the apex, and those in intermediate positions transported both acropetaOy and basipetally. The velocity of movement of "C as computed both from study ofintact fronds and exudate was in the range of 35 to 72 centimeters per hour and these estimates are on the low side. The composition of the translocate as determined from intact fronds was the same as that determined from exudate analysis; furthermore, this composition was nearly identical with that of the photosynthate (40 to 50% mannitol and 40 to 50% amino acids). From these data we conclude that the exudate represents the sieve tube sap and that there is little if any selectivity exercised in the loading and translocation of photoassimilate. An analysis of translocated label in the growing apex is presented and indicates that the synthesis of polymeric compounds such as laminaran, alginate, cellulose, lipids, and "protein" occurs in situ from the transported mannitol and amino acids. Detailed data on chemical composition of sieve tube sap from M. integrifolia and M. pyrifera (L.) C.A. Agardh are given and compared with the sieve tube sap from higher plants. Finally, we show that stipe segments, 60 to 100 centimeters long with three to six
ANALYSIS OF STACKED ANTENNA IN SATELLITE APPLICATION

We propose in this paper a Broadband Stacked Microstrip Patch Antenna structure with a microstrip feeding technique to achieve wide bandwidth and high gain. The proposed stacked antenna executes the frequency range from 4GHz to 10GHz in C band. A parametric analysis is performed to study the inter-element distance effect on antenna performance (directivity, input impedance and radiation efficiency). The results obtained show that in the case of the fully driven element high directivities can be achieved for small distances. The proposed antenna is used for a wide range of applications, such as satellite communication, weather radar systems, applications for Wi-Fi and ISM Band. The C Band is known to perform better on adverse weather conditions than the standard Ku Band for satellite communication. The parameters of the antenna are analysed using the HFSS Tool.
Optimal Elevation of b -Cell 11 b -Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism that Prevents High Fat Diet – Induced b -Cell Failure

Type 2 diabetes ultimately results from pancreatic b -cell failure. Abnormally elevated intracellular regeneration of glucocorticoids by the enzyme 11 b -hydroxysteroid dehydrogenase type 1 (11 b -HSD1) in fat or liver may underlie pathophysiological aspects of the metabolic syndrome. Elevated 11 b -HSD1 is also found in pancreatic islets of obese/diabetic rodents and is hypothesized to suppress insulin secretion and promote diabetes. To de ﬁ ne the direct impact of elevated pancreatic b -cell 11 b -HSD1 on insulin secretion, we generated b -cell – speci ﬁ c, 11 b -HSD1 – overexpressing (MIP-HSD1) mice on a strain background prone to b -cell failure. Unexpectedly, MIP-HSD1 tg/+ mice exhibited a reversal of high fat – induced b -cell failure through augmentation of the number and intrinsic function of small islets in association with induction of heat shock, protein kinase A, and extracellular signal – related kinase and p21 signaling pathways. 11 b -HSD1 2 / 2 mice showed mild b -cell impairment that was offset by improved glucose tolerance. The bene ﬁ t of higher b -cell 11 b -HSD1 exhibited a threshold because homozygous MIP-HSD1 tg/tg mice and diabetic Lep db/db mice with markedly elevated b -cell 11 b -HSD1 levels had impaired basal b -cell function. Optimal elevation of b -cell 11 b -HSD1 rep-resents a novel biological mechanism supporting compensatory insulin hypersecretion rather than exacerbating metabolic disease. These ﬁ ndings have immediate signi ﬁ cance for current therapeutic strategies for type 2 diabetes. and hand-picked
Self-Efﬁcacy Study in Computing Among College Freshmen

Computer Science (CS) is not introduced equitably across K-12 schools, yet it is increasingly a necessary skill regardless of vocational pathway. Co-curricular activities such as summer camps have become a popular way to introduce CS to K-12 students. Researchers at our institution, through partnerships with other educational institutions and practitioners, developed a transdisciplinary approach of teaching CS in K-12 informal learning environments. Building on positive results in the K-12 informal learning environment, researchers are exploring the applicability of the transdisciplinary modules in formal instruction for early college learners in CS0 and CS1 courses. This paper explores self-efficacy data collected from multiple CS0 and CS1 courses. Learners include freshmen in computing majors and in non-computing majors. We compare their self-efficacy growth in computing across race and gender, considering their formal or informal CS education experiences prior to entering college. This work is a part of a larger effort to redesign CS0 and CS1 courses to introduce more complex concepts and important design concepts such as parallel and distributed computing earlier in the curriculum. The authors’ longer-term goal is to investigate active learning strategies that will introduce higher level computer science topics early in the curriculum to enable students to recognize content applicability earlier in their college pathway.
Enhancer Activity ¢ 3 k Transactivation and Ig Protein Acetylation Regulates Both PU.1

Ig (cid:1) gene expression and chromatin structure change during B cell development. At the pre-B cell stage, the locus is relatively hypoacetylated on histone H3, whereas it is hyperacetylated at the plasma cell stage. We ﬁnd in this study that the histone deacetylase inhibitor, trichostatin A (TSA) stimulated 3 (cid:1) enhancer activity through the PU.1 binding site. TSA also stimulated PU.1 transactivation potential. PU.1 activity was increased by the coactivator acetyltransferase protein, p300, and p300 physically interacted with PU.1 residues 7–30. PU.1 served as a substrate for p300 and was acetylated on lysine residues 170, 171, 206, and 208. Mutation of PU.1 lysines 170 and 171 did not affect PU.1 DNA binding, but did lower the ability of PU.1 to activate transcription in association with p300. Lysine 170 was acetylated in pre-B cells and plasmacytoma cells, but TSA treatment did not stimulate PU.1 acetylation at this residue arguing that a second mechanism can stimulate 3 (cid:1) enhancer activity. Using chromatin immunoprecipitation assays we found that TSA caused preferential acetylation of histone H3 at the 3 (cid:1) enhancer. The relevance of these studies for PU.1 function in transcription and hemopoietic development is discussed. The Journal of Immunology, 2005, 175: 5160–5169.
Controlling robot formations by means of spatial reasoning based on rough mereology

This research focuses on controlling robots and their formations using rough mereology as a means for spatial reasoning. The authors present the state of the art theory behind path planning, robot cooperation domains and ways of creating robot formations. Furthermore, the theory behind Rough Mere-ology as a way of implementing mereological potential field based path creation and navigation for single and multiple robots is described. An implementation of the algorithm is shown in simulation using Ro-boSim simulator. Five formations are tested (Line, Rhomboid, Snake, Circle, Cross) along with three decision systems (First In, Leader First, Horde Mode) as compared to other methods.
Finding a Model that Provides High Proﬁts with Web Usage Mining: A Case Study

As the methods of data collection and analysis evolve, they are developed in ways that can transform this data into intended results. For this purpose, it is necessary to draw a road map of the work to be done with planning and to reach the aimed result. In this study, a plan was made for the selected web site and the results were gathered within this plan and a result that can give an idea about the changes needed to reach the goals by using the appropriate models together.