Miracle-dz/UniFAR-FTUs huggingface dataset:
Shear wave velocity structure of Iranian plateau: using combination of ambient noise cross-correlations (C

S U M M A R Y We use continuous seismic data recorded between January 2013 and December 2014 by Iranian Seismological Center (IRSC) and International Institute of Earthquake Engineering and Seismology (IIEES) networks. Empirical Green’s functions between the vertical components of the station pairs are reconstructed by cross-correlating the seismic noise (C1) and recorrelating the coda of the noise-correlations (C3). The combination of these two methods makes it possible to increase the number of retrieved empirical Green’s functions, which improves the spatial resolution of the tomographic imaging. We measure and then invert Rayleigh wave dispersion traveltimes to produce 2-D group velocity maps from a period range of 5–40 s for Iranian plateau. The sensitivity tests of tomography using traveltimes from C1 and C1+C3 indicates that C1+C3 indeed enhances resolution. In general, results from seismic noise imaging show good agreement with the local geological units. The shear wave velocity sections resulting from the Bayesian inversion of dispersion curves are interpreted along four profiles in different directions in order to cover the main tectonics of Iranian plateau down to 60 km depth.
Targeting retinoblastoma binding protein 6 (RBBP6) as an anti-ovarian cancer therapeutic strategy

vi Acknowledgements . viii Table of Abbreviations . ix List of figures . xii List of Tables . xiv CHAPTER ONEINTRODUCTION AND LITERATURE REVIEW . xx Introduction . 1 1.1 Ovarian cancer overview . 1 1.2 Causes and Risk factors. 3 1.2. 1 The gonadotropin hypothesis. 3 1.2. 2 The incessant ovulation theory . 4 1.3 Genetic risk factors. 4 1.4 Epidemiology . 6 1.5 Apoptosis as cell division guardian . 7 1.5. 1 Apoptotic pathways . 8 1.5. 2 Cell cycle regulation and p21 . 9 1.5. 3 Regulation and failure of apoptosis . 9 xvi 1.5. 4 Role of apoptosis in ovarian follicle development and maintenance . 10 1.6 Apoptosis in ovarian cancer and its therapeutic targets . 11 1.6. 1 Targeted therapy in Ovarian Cancer . 12 1.6. 2 Tyrosine Kinases . 14 1.7 Molecular therapeutic targets in ovarian cancer . 15 1.7. 1 Angiogenesis inhibitors . 15 1.7. 2 Inhibitors of the epidermal growth factor receptor (EGFR) . 15 1.7. 3 Aurora kinase inhibitors . 16 1.7. 4 Poly ADP Ribose Polymerase (PARP) inhibitors. 16 1.7. 5 Platelet-derived growth factor (PDGF) receptor inhibitors . 17 1.7. 6 MTOR inhibitors . 18 1.7. 7 Targeting Bcl-2 Family in ovarian cancer and apoptosis . 18 1.7. 8 Minimizing expression of Inhibitors of Apoptosis (IAP) as target for ovarian cancer. 20 1.7. 9 Therapuetical potential of TNF family members. 22 1.7. 10 Wild-type p53: the genomic guardian target . 23 1.7. 11 Other apoptotic molecular targets for ovarian cancer cells . 26 1.8 Paclitaxel and Camptothecin derivatives as conventional chemotherapy in ovarian cancer . 33 1.8. 1 Paclitaxel . 33 1.8. 2 Camptothecin . 34
1: Final Report on the Safety Assessment of Butyl Benzyl Phthalate

Butyl Benzyl Phthalate (BBP) is an aromatic ester that i s used as a plasticizer at concentrations below 1 . O%. After oral and intravenous (iv) administration, BBP was rapidly excreted. The oral LD,, was: 2.3 g/kg for F344/N rats, and 4.2 6.2 g/kg for B6C3F1 mice. Rats and mice exposed to high concentrations of BBP lost weight, had testicular atrophy, hemorrhages, and hepatomegaly. No toxicity was reported in an oral subchronic toxicity study using dogs. BBP was not a reproductive toxin to CD-1 and B6C3F1 mice; however, BBP caused dose-dependent microscopic degenerative changes in the testes of male F344 rats. BBP was nonmutagenic in the Ames Test, 151 78Y TK mouse lymphoma mutagenesis assay, dominant lethal mutagenicity assay, and BAlW3T3 cell transformation assay. An increase in the incidence of mononuclear cell leukemia in female F344/N rats was not considered to be related to the exposure to high doses of BBP. BBP was not carcinogenic in studies using B6C3F1 and A/St mice. Slight transient dermal and ocular irritation was produced by undiluted BBP in rabbits. In human dermal studies, BBP was not a significant irritant nor sensitizer. On the basis of data presented in this report, it is concluded that butyl benzyl phthalate is a safe cosmetic ingredient in the present practices of use and concentration.
Novel stem cell and PHBHHx approaches to tendon repair

Tendon injuries continue to be a financial burden on the health care system of many western countries, whilst also remaining common and a significant challenge within the orthopaedic discipline with no consensus of opinion on the best therapeutic regime to be employed. Many polymers have been investigated for use in tendon repair. A range of polymers have shown good integration with limited immune response. However, to date no implant has been capable of delivering the physical properties observed in native undamaged tendon. Many of the polymers implanted have resulted in re-rupture or reduced mechanical function. Therefore, improvements are required in the choice of polymer and mechanical properties of the polymer are required. One means of achieving such improvements is to utilise co-polymers such as PHBHHx, which have shown favourable elastic properties when the ratio of HHx to PHB has been increased. Therefore, a PHBHHx polymer based scaffold was investigated as a potential scaffold for tendon repair. Whilst, also investigating the potential of FGF-4, FGF-6 and FGF-8 to differentiate both human embryonic and mesenchymal stem cells towards a tenocyte-like lineage. Finally, an investigation into whether a controlled production of PHBHHx based nanoparticles could produce different nanoparticles sizes that can be predicted and result in differing release profiles. This may allow for the synthesis of size controlled nanoparticles capable of delivering differing drug concentrations and sustained release properties. W. R. Webb PhD Thesis Abstract and
Alzheimer's Disease: Longitudinal CT

A 3-year longitudinal study was conducted with 50 Alzheimer's disease patients and 45 elderly control subjects. All study participants received an extensive evaluation that included brain CT at baseline and follow-up. Quantitation of ventricular size, using both linear and volume methods, revealed highly significant cross-sectional and longitudinal differences between the Alzheimer patients and control subjects. Specifically, the annual rate of change in ventricular volume was approximately 9% in the Alzheimer patients and approximately 2% in the controls. The presence of age-related white matter lesions had no effect on the clinical course of the patients or on the changes in ventricular size. Among the Alzheimer patients, the rate of clinical decline was strongly related to the rate of change in ventricular size. Baseline ventricular measurements were of no value in predicting the subsequent rate of clinical deterioration or ventricular enlargement. The results suggest that changes in ventricular size closely reflect the clinical changes in Alzheimer patients.
Prevalence of Osteoporotic Changes in Panoramic Radiographs of Patients showing Carotid Calcifications

Objectives: Atherosclerosis and Osteoporosis are two of the most prevalent chronic diseases in the western world. They share common risk factors and many studies suggest an association between arterial calcification and low bone mass possibly due to common etiology. (1-3) The aim of this pilot study is to study the prevalence of osteoporotic changes in patients showing evidence of carotid plaques on panoramic radiographs. Methods: Of the panoramic radiographs done on dental school patients from 2004-2005, 24 radiographs showing frank evidence of carotid plaque were selected and reviewed for osteoporotic changes using the criteria by White et al.(4) Results: 95% of our study patients showed evidence of osteoporotic changes in their mandibular cortex. Conclusions: Given the results of our pilot study, it is important that dentists should screen for osteoporosis in patients showing carotid atherosclerosis.
The Practice of Homework : A Critical Ethnography : The Story of Four Families

This thesis explores the homework experiences of four students and their families through the lens of critical inquiry. The stories of the participants are told through conversational interviews with students and their parents/caregivers, as well as their classroom teacher, in a bounded study. Drawing on these stories, the issue of homework is 'problematised', and analysed in light of issues such as institutional power and
Review of New Compounds Available in Australia for the Treatment of Attention-Deficit Hyperactivity Disorder

Objective: To examine the pharmacodynamic and pharmacokinetic properties, efficacy, safety and cost of Ritalin LA, Concerta and Strattera, three compounds recently released in Australia for the treatment of attentiondeficit hyperactivity disorder (ADHD). Methods: MEDLINE was searched for relevant review articles and primary treatment studies. Data were augmented by product information supplied by the respective manufacturers. Costing information was obtained by surveying five community pharmacy outlets in Newcastle-Lake Macquarie, New South Wales. Results: The three compounds reviewed have similar tolerability and efficacy to immediate-release methylphenidate, with the advantage of once daily dosing. The properties of these agents, particularly Strattera, make them less able to be abused. Ritalin LA may be superior to Concerta in controlling symptoms of ADHD in the first 4 h following ingestion, but the data should be interpreted with caution. Conclusions: The newer treatments for ADHD offer advantages over immediate-release methyphenidate in dosing schedule and duration of action that may be of particular benefit to adolescent and adult patients. Prescription of these medications may be limited by their expense to the patient.
Dr. Reimer's Response

principle dictates that protection should be established before interacting with the lesion; this cannot be accomplished using the Mo.Ma device when the stenosis lies in the CCA (Fig. 3D). (3) When the procedure is completed and the Mo.Ma system is removed, the ECA balloon has to be dragged down without protection because the CCA balloon is already deflated. When the stent crosses the ECA ostium, the balloon catheter is compressed between the stent and the arterial wall, so mobilizing the balloon catheter can detach fragments of plaque. In their article, Reimers and colleagues wrote, ‘‘In contrast to the Parodi Anti-Embolic Device, which features an arteriovenous shunt that provides continuous reversal of flow, the Mo.Ma blocks antegrade flow and uses intermittent or final aspiration of blood to remove debris. ’’ Honestly, I don’t see the contrast between the two systems; both methods reverse the flow in the ICA: the ArteriA continuously and the Mo.Ma intermittently or at the end of the procedure. My question to the authors is: why aspirate only intermittently or at the end of the procedure? Continuous flow reversal does not increase intolerance, probably just the opposite.5 HITS (or MES) can occur in between aspirations, so why not establish permanent flow reversal? My comments are not intended to overshadow the success achieved by the Mo.Ma device, but rather to open a debate on how to perfect the current technology based upon proximal occlusion as a protection method for carotid stenting. The goal should be to completely suppress the MES (or HITS). I believe that continuous flow reversal achieves the goal. While my comments are based on scientific principles, I have a conflict of interest as a stockholder of ArteriA, so I welcome a response from the authors.
2 Final Report on the Safety Assessment of Benzalkonium Chloride

Benzalkonium Chloride is a mixture of alkylbenzyldimethylammonium chlorides. The ingredient is used in cosmetic products as a foaming cleansing and bactericidal agent at concentrations up to 5.0%. The compound was nonmuta-genic in several different cell assays. It is a skin and ocular irritant at concentrations greater than 0.1%. This cosmetic ingredient is not a sensitizer to normal humans at concentrations of 0.1%, but may be to individuals with diseased skin. It is concluded that Benzalkonium Chloride can be safely used as an antimicrobial agent at concentrations up to 0.1%.
Management of Phytophthora Induced foot rot and gummosis of kinnow mandarin in low hills of Himachal Pradesh

All the fungicides have healing effect on lesions of foot rot when applied as drenching and pasting. Aliette (0.25%) has resulted 71.6% lesion healing followed by Ridomil MZ (63.7%) at the same concentration. However, Blitox (0.3%) controlled 42.0% of lesion showing constant effect in every year. In case of Aliette the healing effect was fou'nd increased in every year. Gum exudation was totally absent in Ridomil MZ, whereas. maximum in the trees treated with Indofil M-45. More number of new shoots has been recorded in Aliette and Ridomil MZ i.e. 32.8 and 32.0 percent, respectively along with dark green leaf colour. Foliar spray of Aliette has remarkable effect on the healing of lesions and gum exudation caused by Phytophthora species in kinnow mandarin. Maximum control (85.0%) was obtained with 0.25% concentration. As the concentration was raised from 0.1 to 0.3% the lesion healing also increased from 23.57 to 88.1%. Numbers of new shoots were more at 0.2, 0.25 and 0.3 persent concentrations of Aliette. The effect on leaf colour was noticed at 0.15% concentration which increased with the increase in concentration.
Group Sequential Monitoring of Multi-Armed Clinical Trials

Monitoring of two-armed clinical trials using group sequential methods has been implemented for over 20 years. This paper considers analogous monitoring procedures for multi-armed clinical trials. Monitoring the trial based on repeated tests of a global null hypothesis, monitoring of comparisons of several treatments to a control, and monitoring of all pair-wise comparisons are considered. The procedure of choice for a given situation will depend on how the application at hand is best formulated.
Infective Endocarditis

Infective endocarditis is a life-threatening illness associated with significant morbidity and mortality. Previously a uniformly fatal disease, antibiotic therapy has reduced the mortality of native valve endocarditis to less than 20%. The incidence of infective endocarditis has not decreased, however, and 20,000 new cases are reported each year. Continued improvement in the prognosis of endocarditis is largely dependent on early and accurate diagnosis of the disease and its complications. Echocardiography has assumed an important role in the evaluation of infective endocarditis, both for the detection of vegetations and in the assessment of complications of the infectious process.
Research Assessment

The Royal Charter states the aim of the Institute is: 'To promote for the public benefit, by all available means, the general advancement of the science and practice of measurement and control technology and its application'. The purpose of this article is to draw attentian to what we consider an important issue which is currently facing the measurement and control research community within the United Kingdom. University research relies for much of its funding on the dual mechanisms of direct goverment funding through the Higher Education Funding Councils and grant support from the Research Councils. Universities have now been subjected to three research assessment exercises (RAEs), which determine the Funding Councils financial allocations for the succeeding 4 years. These have taken place in 1988, 1992 and 1996, with the next being due in 2000. The RAE aims to measure research performance in the preceding 4 years by using indicators such as publication quality and success in obtaining external grants. The last RAE, in 1996, grouped research into sixty nine separate areas (known as Units ofAssessment (UoAs)). Universities can make a submission in as many of the 69 areas as they deem appropriate. Each UoA was assessed by a specialist panel composed of eminent academics and industrialists, whose task was to grade each submission on a 7 point scale. The seven point scale, together with the number of researchers in the UoA, is used to determine the level of funding for the next 4 years. In the opinion of the authors, the science and practice of measurement and control has suffered in each of the RAEsby not being considered as a separate UoA. This may be taken in the context that included within the sixty nine separate UoAs recognised, were areas such as: Environmental Studies. Many universities were therefore forces to submit measruement and control research under the UoA of Electrical Engineering (which included
Practice Report: A Master Trainer Class for Professionals in Teaching the UltraCane Electronic Travel Device

the course load and with being away from their homes and families. However, the online students lived in their homes and communities, had a built-in support system, and were taking only one or two courses at any one time. Moreover, the quality of the involvement with the students in the summers more than made up for the lack of student interactions during the academic year. Everyone, including me, has made the most of the summer student-faculty interactions. It has been rejuvenating and a joy to get together and to be immersed in O&M for five weeks each summer. The quality of these five-week interactions is greater than that of the traditional on-campus model during the academic year.
In Children with Profound Bilateral Hearing Impairment, is Sound Localization for Bilateral Cochlear Implant Users Better Than for Those Who Do Not Receive a Second Implant?

This critical review examines the sound localization abilities of children with profound bilateral hearing impairment using two cochlear implants and compares these abilities to children who are using only one. Study designs are all case-control studies. Overall, research supports the inclusion of a second cochlear implant to optimize sound localization abilities. It is not yet certain how age at implantation, order of implantation (i.e. simultaneous vs. sequential), and time since implantation (i.e. 2 months vs. 2 years) individually influence sound localization abilities.
The New Classification Criteria of Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a prototype for multi-system, autoimmune diseases of unknown etiology, characterized by the production of autoantibodies. SLE can involve any organ system of the body with constitutional symptoms, including musculoskeletal, skin, renal, neuropsychiatric, cardiovascular, respiratory and gastrointestinal systems. These wide spectra of disease manifestations have made disease classification difficult. American College of Rheumatology (ACR) proposed classification criteria for SLE for research purpose in 1982, which had been widely used for research purpose and not for diagnosis. In 1997, these criteria were updated with further recognition of antiphospholipid antibodies, but not validated. But ACR criteria didn``t still meet the necessity for earlier diagnosis of SLE. In order to improve clinical relevance and incorporate new knowledge to the field of lupus immunology, the Systemic Lupus Erythematosus International Collaborating Clinics (SLICC), an international lupus expert group dedicated to clinical research on lupus, revised the ACR systemic lupus classification criteria in 2012. The new 2012 SLICC criteria were validated using a large set of patient scenarios rated by experts. The history and diagnostic utility of SLE criteria are covered in this review.
Short term effect of breastfeeding on postpartum maternal anthropometry in Owerri, Nigeria

Background : Pregnancy related weight gain and retention of gained weight during the postpartum period has remained a challenge to African women. Studies have revealed that breastfeeding has various benefits on both mother and child, however studies on the ability to cause reduction in postpartum maternal weight reported conflicting results. Aim : This prospective study aims to investigate the effect of different infant breastfeeding methods on postpartum weight loss on Nigeria women. Subjects and Methods: A total of 72 pregnant women in labor were recruited based on set criteria and anthropometric measurements were taken 24 hours after delivery then repeated 6 weeks after. Mothers were grouped under the following: Exclusively breastfed group (EBF complementary breastfeeding (CBF) and no breastfeeding group (NBF). Data entry and analysis was done using SPSS viewer (13), with P value ≤0.05 considered as significant. Results : A significant difference (p = 0.029) in average postpartum weight loss was observed in the EBF group, CBF group and the NBF group (6.86kg, 5.22kg and 3.00kg respectively). Also average loss in BMI (2.63kg/m2, 2.06kg/m2and 1.13kg/m2 respectively) was significant (p = 0.018) along with the average Loss in Mid-Thigh Circumference (1.09cm, 0.97cm and 0.69cm respectively) with p=0.025. Conclusion : Reduction in maternal postpartum weight is a benefit of breastfeeding even on short term basis especially if practiced exclusively. This information can be pushed forward as a motivating factor for breastfeeding and post-partum weight reduction. Key Words : Maternal anthropometry, Breastfeeding, Lactation, weight loss, Nigeria.
Performance of Popular HPC Applications on the Intel Knights Landing Platform

We present direct performance measurements for six popular HPC applications in the Knights Landing (KNL) platform. Performance numbers for Sandy Bridge and Haswell processors are provided for contrast. The applications (NAMD, Gromacs, FLASH4, WRF, Quantum Espresso and NCBI BLAST) were selected from among the ten most used in the Stampede supercomputer at the Texas Advanced Computing Center as well as good representative of workloads used by large number of users and, given their diversity, should be representative of typical HPC workloads. All runs were performed with publicly available codes without modification – except a single line added to FLASH4 to enable threading in a given code section – and so results should be expected to improve as developers gain access to KNL. Current results are promising, with execution on a single KNL processor showing speedups up to 2.7X with respect to a dual socket Sandy Bridge and up to 1.7x with respect to a dual socket Haswell.
Metabolic Endotoxemia and Inhibition of Direct Bone Regeneration: A Pilot Study

Aims: Clinical and pre-clinical studies have demonstrated that alcohol abuse, aging, diabetes and rheumatoid arthritis are associated with increased risk of fractures compounded with impaired fracture repair. We note that these and other pathologies are characterized by chronic inflammation (CI) as a risk factor. How these CI pathologies inhibit bone repair is unclear, but one candidate mediator is endotoxin (lipopolysaccharide/LPS). LPS promotes inflammation and is present in increased serum concentrations in some inflammatory conditions. The distraction osteogenesis (DO) model developed in this laboratory provides the opportunity to isolate and study the effects of CI on direct bone formation during bone regeneration. The aim of this study was to determine whether endotoxin at concentrations that mimic levels reported