Miracle-dz/UniFAR-FTUs huggingface dataset:
Habitude et principe de compatibilité dans le modèle du comportement planifié : décisions pro-environnementales et automobile

Le modele du comportement planifie (Ajzen, 1991) met l’accent sur les antecedents raisonnes du comportement. Le principal objectif de notre travail concerne les comportements a faible opportunite, ou peu frequents, qui ne peuvent donc pas etre habituels (ex : achat automobile). Si un comportement est nouveau, on ne peut pas mesurer de comportement passe compatible (non respect du principe de correspondance) mais on peut mesurer le comportement passe et les habitudes comportementales dans des situations analogues (comportement passe connexe). Dans ce cas, le comportement passe serait utilise par les individus comme une information. Trois recherches experimentales (N=992) ont ete conduites dans le domaine des intentions pro-environnementales aupres d’acheteurs de vehicules neufs. Les deux premieres etudes etaient focalisees sur l’achat de Vehicule Propre et Econome (VPE) et la troisieme etude sur l’utilisation de la climatisation. Nos resultats montrent que les mesures connexes contribuent significativement a la prediction de comportements a faible opportunite. L’habitude mesuree a un niveau general contribue significativement au modele alors que l’etat affectif joue un role indirect.
Recognition of SAR Image Based on SVM and New Invariant Moment Feature Extraction

Support Vector Machine (SVM) is regarded as a good alternative of the traditional learning classification. Because of its excellent learning performance, it has become a research hot spot in the field of machine learning. This paper describes the new invariant moment feature extraction of SAR objectives based on shape feature, then classify and train the eigenvectors by using SVM. The excellent recognition rates achieved in experiments indicate that SVM is well suited for SAR image target recognition.
Evaluation of Anopheline Mosquitoes (Diptera: Culicidae) from the Republic of Korea for Plasmodium vivax Circumsporozoite Protein

Abstract As part of an on-going malaria surveillance effort conducted by the U.S. Forces Korea, Republic of Korea (ROK), a total of 28,286 anopheline mosquitoes was tested for the presence of Plasmodium vivax circumsporozoite (CS) protein. Mosquitoes were collected (using a variety of light and baited traps) from 29 locations throughout the ROK (the majority were collected near the de-militarized zone), identified to species, and tested by enzyme-linked immunosorbent assay for the presence of P. vivax 210 and P. vivax 247 CS protein. Recent evidence suggests that characters used to separate Anopheles sinensis Wiedemann from An. lesteri Baisas & Hu are unreliable; therefore, the data have been analyzed by grouping these two species. A total of 25,365 Anopheles sinensis/lesteri, 2,890 An. yatsushiroensis Miyazaki, and 31 An. sineroides Yamada was tested. Of these, one pool of 10 An. sinensis/lesteri collected on 9 September 1999 at Camp Howze and one pool of nine An. sinensis/lesteri collected on 13 September 1999 at Camp Bonifas were positive for P. vivax 247.
Mnd1/Hop2 Facilitates Dmc1-Dependent Interhomolog Crossover Formation in Meiosis of Budding Yeast

ABSTRACT During meiosis, each chromosome must pair with its homolog and undergo meiotic crossover recombination in order to segregate properly at the first meiotic division. Recombination in meiosis in Saccharomyces cerevisiae relies on two Escherichia coli recA homologs, Rad51 and Dmc1, as well as the more recently discovered heterodimer Mnd1/Hop2. Meiotic recombination in S. cerevisiae mnd1 and hop2 single mutants is initiated via double-strand breaks (DSBs) but does not progress beyond this stage; heteroduplex DNA, joint molecules, and crossovers are not detected. Whereas hop2 and mnd1 single mutants are profoundly recombination defective, we show that mnd1 rad51, hop2 rad51, and mnd1 rad17 double mutants are able to carry out crossover recombination. Interestingly, noncrossover recombination is absent, indicating a role for Mnd1/Hop2 in the designation of DSBs for noncrossover recombination. We demonstrate that in the rad51 mnd1 double mutant, recombination is more likely to occur between repetitive sequences on nonhomologous chromosomes. Our results support a model in which Mnd1/Hop2 is required for DNA-DNA interactions that help ensure Dmc1-mediated stable strand invasion between homologous chromosomes, thereby preserving genomic integrity.
Multiple Traditions in Populism Research: Toward a Theoretical Synthesis

This contribution to the APSA Comparative Politics Newsletter provides an introduction to the conceptualization of populism. As we explain, there are three main traditions in populism research: populism as a political strategy, populism as a political ideology, and populism as a discursive style. Each of these traditions imply different levels of analysis. Among other things, we advocate adopting a minimal definition of populism that treats populism as an attribute of political claims rather than actors.
INFORMATION & COMMUNICATIONS TECHNOLOGY IN EDUCATION | RESEARCH ARTICLE Integrating Information Technology's competencies into academic nursing education-An action study

2 Abstract: Today, in the digital age, we are committed to prepare the future nurse for the information technology-rich workplace, and to help them reducing the "shock reality" upon arriving at the clinical setting. The main aim of the study is to promote the knowledge of Information Competencies Technology among nurses' educators and student. The method was an action research process that started by collecting the data—by literature review, nurses' interviews and students' survey, analyzing and interpreting the data, and developing a plan of action, including curriculum change for the students and workshops for the nurse educators. Two benefits were driven from this action: updating and developing academic courses and adopt- ing pedagogic tools for nurses' educators. In conclusion, the overarching theme of this project is the need for Information Technology to be integrated within the larger body of the nursing learning program, and its implication for educators and students.
The chromosomal integration site for the Streptomyces plasmid SLP1 is a functional tRNATyr gene essential for cell viability

The genetic element SLP1 exists in nature as a single DNA segment integrated into the genome of Streptomyces coelicolor. Upon mating with Streptomyces lividans, a closely related species, SLP1 undergoes precise excision from its chromosomal site and is transferred into the recipient where it integrates chromosomally. Previous work has shown that integration and excision involve site‐specific recombination between a chromosomal site, attB, and a virtually identical sequence, attP, on SLP1. We demonstrate here by means of gene replacement that a tRNATvr sequence that overlaps part of the attB site of S. lividans is both biologically functional and essential for cell viability. The requirement for this tRNA gene has been used to stabilize the inheritance of a segrationally unstable plasmid in cells lacking a chromosomal attB site. The evolution of an essential DNA locus as an attachment site for a chromosomally integrating genetic element represents a novel mechanism of biological adaptation.
VESTIBULAR FUNCTION AND MOTOR PROFICIENCY OF CHILDREN WITH IMPAIRED HEARING, OR WITH LEARNING DISABILITY AND MOTOR IMPAIRMENTS

Vestibular status and motor proficiency of 30 hearing‐impaired and 15 motor‐impaired learning‐disabled children were documented to determine whether vestibular loss can account for deficits in motor co‐ordination. Vestibular loss was differentiated from sensory organization deficits by means of VOR and postural orientation test results, which were compared with those of 54 normal seven‐to 12‐year‐olds. Reduced or absent vestibular function in 20 hearing‐impaired children did not affect development of motor proficiency, except in specific balance activities. However, sensory organization deficits in the learning‐disabled group and in three of the hearing‐impaired children were associated with widespread deficits in motor proficiency.
Involvement of the bcl-2 gene in Hodgkin's disease.

A major obstacle to investigations of Hodgkin's disease is the paucity of malignant cells, i.e., Reed-Sternberg cells and their variants, in tissues of patients with this disease. Consequently, the pathogenesis, cell of origin, and clonality of this relatively frequent lymphoma have remained unresolved. Results of recent studies suggest that in some instances Reed-Sternberg cells carry rearranged immunoglobulin heavy-chain joining region (JH) loci as well as chromosomal translocations involving band 14q32. Prompted by these findings, we sought to determine if the t(14;18) (q32;q21) translocation of follicular, non-Hodgkin's B-cell lymphoma was associated with Hodgkin's disease. To detect the possible t(14;18) (q32;q21) translocation within the rare malignant cells of Hodgkin's disease, we amplified sequences created by the t(14;18) translocation using the polymerase chain reaction (PCR). With this approach, DNA sequences carrying the direct fusion of the major breakpoint region of the candidate oncogene, bcl-2, derived from chromosome 18q21, with JH on chromosome 14q32 can be detected in as few as one in 10(5)-10(6) cells. In the present study, joined bcl-2/JH sequences were detected in tissues involved by Hodgkin's disease in 17 of 53 (32%) patients. The frequent association of bcl-2 translocation with Hodgkin's disease suggests that this oncogene has a role in the pathogenesis of Hodgkin's disease. That bcl-2 is involved in a major class of lymphoma in addition to follicular lymphoma implies a role for additional factors responsible for generating the two distinctive clinical and pathologic disease states.
The impact of screening, brief intervention and referral for treatment in emergency department patients' alcohol use: a 3-, 6- and 12-month follow-up.

AIMS This study aims to determine the impact of Screening, Brief Intervention and Referral for Treatment (SBIRT) in reducing alcohol consumption in emergency department (ED) patients at 3, 6, and 12 months following exposure to the intervention. METHODS Patients drinking above the low-risk limits (at-risk to dependence), as defined by National Institute of Alcohol Abuse and Alcoholism (NIAAA), were recruited from 14 sites nationwide from April to August 2004. A quasi-experimental comparison group design included sequential recruitment of intervention and control patients at each site. Control patients received a written handout. The Intervention group received the handout and participated in a brief negotiated interview with direct referral for treatment if indicated. Follow-up surveys were conducted at 3, 6, and 12 months by telephone using an Interactive Voice Response (IVR) system. RESULTS Of the 1132 eligible patients consented and enrolled (581 control, 551 intervention), 699 (63%), 575 (52%) and 433 (38%) completed follow-up surveys via IVR at 3, 6, and 12 months, respectively. Regression analysis adjusting for the clustered sampling design and using multiple imputation procedures to account for subject attrition revealed that those receiving SBIRT reported roughly three drinks less per week than controls (B = -3.00, SE = 1.06, P < 0.05) and the level of maximum drinks per occasion was approximately three-fourths of a drink less than controls (B = -0.76, SE = 0.29, P < 0.05) at 3 months. At 6 and 12 months post-intervention, these effects had weakened considerably and were no longer statistically or substantively significant. CONCLUSION SBIRT delivered by ED providers appears to have short-term effectiveness in reducing at-risk drinking, but multi-contact interventions or booster programs may be necessary to maintain long-term reductions in risky drinking.
Comparative genomic hybridization of ductal carcinoma in situ of the breast—evidence of multiple genetic pathways

There is strong evidence that ductal carcinoma in situ (DCIS) represents a precursor lesion of invasive breast cancer. In order to analyse specific chromosomal alterations of DCIS, 38 paraffin‐embedded specimens of DCIS and six associated invasive carcinomas were examined by means of comparative genomic hybridization (CGH). Losses of 16q material were seen almost exclusively in well‐ and intermediately‐differentiated DCIS. These two subgroups differed in the average number of genetic imbalances, 2·5 and 5·5 respectively. Additionally, a higher frequency of gains of 1q and losses of 11q material was seen in intermediately‐differentiated in contrast to well‐differentiated DCIS. Poorly‐differentiated DCIS displayed a higher frequency of amplifications (17q12, 11q13) and a higher average rate of genetic imbalances (7·1). Analysis of adjacent invasive breast carcinoma revealed a genetic pattern almost identical to the one seen in the DCIS counterpart. These data characterize DCIS as a genetically far‐advanced, heterogeneous lesion and as a direct precursor of invasive breast cancer. Copyright © 1999 John Wiley & Sons, Ltd.
H. pylori infection, atrophic gastritis, cytokines, gastrin, COX-2, PPAR gamma and impaired apoptosis in gastric carcinogenesis.

BACKGROUND Helicobacter pylori (Hp) infection represents a crucial factor in pathogenesis of gastric cancer (GC). Factors emanating from bacterium as well as from environmental contributions such as salt diet and inadequate supply of antioxidants, affect the risk for GC development. RESULTS Atrophic gastritis is considered to be a precursor lesion of intestinal type GC that is accompanied by hypergastrinemia with subsequent induction of cyclooxygenase-2 (COX-2), whose products are responsible for slowing apoptosis and for angiogenesis in GC tumor. The involvement of proinflammatory cytokines (especially IL-1 and IL-8) and reactive oxygen species (ROS) due to NF kappa B activation, increased cell proliferation combined with inhibition of apoptosis as well as upregulation of peroxisome proliferation activated receptor gamma (PPAR gamma) and inducible nitric oxide synthase (iNOS) appear to be major molecular biology alterations in pathogenesis of GC. CONCLUSIONS These results suggest the therapeutic usefulness of inhibitors of gastrin expression and release such as powerful somatostatin analogs (Sandostatin) or blockers of COX-2 (coxibs) in the control of GC development and progression as chemopreventive agents. Comparative genomic and proteomic is the key in identifying biomarkers in host and bacterium for the prediction of gastric cancer in Hp-infected patients.
Expression of the Yeast PIS 1 Gene Requires Multiple Regulatory Elements Including a Rox 1 p Binding Site *

The PIS1 gene is required for de novo synthesis of phosphatidylinositol (PI), an essential phospholipid in Saccharomyces cerevisiae. PIS1 gene expression is unusual because it is uncoupled from the other phospholipid biosynthetic genes, which are regulated in response to inositol and choline. Relatively little is known about regulation of transcription of the PIS1 gene. We reported previously that PIS1 transcription is sensitive to carbon source. To further our understanding of the regulation of PIS1 transcription, we carried out a promoter deletion analysis that identified three regions required for PIS1 gene expression (upstream activating sequence (UAS) elements 1–3). Deletion of either UAS1 or UAS2 resulted in an 45% reduction in expression, whereas removal of UAS3 yielded an 84% decrease in expression. A comparison of promoters among several Saccharomyces species shows that these sequences are highly conserved. Curiously, the UAS3 element region ( 149 to 138) includes a Rox1p binding site. Rox1p is a repressor of hypoxic genes under aerobic growth conditions. Consistent with this, we have found that expression of a PIS1-cat reporter was repressed under aerobic conditions, and this repression was dependent on both Rox1p and its binding site. Furthermore, PI levels were elevated under anaerobic conditions. This is the first evidence that PI levels are affected by regulation of PIS1 transcription.
Additive effect of mPer1 and mPer2 antisense oligonucleotides on light-induced phase shift

It is well known that light induces both mPer1 and mPer2 mRNA in the suprachiasmatic nucleus. We have reported that mPer1 antisense oligonucleotides (ODNs) inhibited the light-induced phase delays of mouse locomotor rhythm. In this study, we asked whether both or either mPer1 or mPer2 expression is necessary to induce the phase shift. We examined the effects of inhibition of mRNA expression on light-induced phase delays of mouse circadian behavior rhythm. Light-induced phase delays were moderately attenuated by microinjection of mPer1 or mPer2 antisense ODN, but not by mPer3 antisense or mPer1, mPer2 scrambled ODNs, whereas following simultaneous injection of both mPer1 and mPer2 antisense ODNs they disappeared. The present results suggest that acute induction of mPer1 and mPer2 gene play an additive effect on photic entrainment.
Prospective multicenter assessment of risk factors for rod fracture following surgery for adult spinal deformity.

OBJECT Improved understanding of rod fracture (RF) following adult spinal deformity (ASD) surgery could prove valuable for surgical planning, patient counseling, and implant design. The objective of this study was to prospectively assess the rates of and risk factors for RF following surgery for ASD. METHODS This was a prospective, multicenter, consecutive series. Inclusion criteria were ASD, age > 18 years, ≥5 levels posterior instrumented fusion, baseline full-length standing spine radiographs, and either development of RF or full-length standing spine radiographs obtained at least 1 year after surgery that demonstrated lack of RF. ASD was defined as presence of at least one of the following: coronal Cobb angle ≥20°, sagittal vertical axis (SVA) ≥5 cm, pelvic tilt (PT) ≥25°, and thoracic kyphosis ≥60°. RESULTS Of 287 patients who otherwise met inclusion criteria, 200 (70%) either demonstrated RF or had radiographic imaging obtained at a minimum of 1 year after surgery showing lack of RF. The patients' mean age was 54.8 ± 15.8 years; 81% were women; 10% were smokers; the mean body mass index (BMI) was 27.1 ± 6.5; the mean number of levels fused was 12.0 ± 3.8; and 50 patients (25%) had a pedicle subtraction osteotomy (PSO). The rod material was cobalt chromium (CC) in 53%, stainless steel (SS), in 26%, or titanium alloy (TA) in 21% of cases; the rod diameters were 5.5 mm (in 68% of cases), 6.0 mm (in 13%), or 6.35 mm (in 19%). RF occurred in 18 cases (9.0%) at a mean of 14.7 months (range 3-27 months); patients without RF had a mean follow-up of 19 months (range 12-24 months). Patients with RF were older (62.3 vs 54.1 years, p = 0.036), had greater BMI (30.6 vs 26.7, p = 0.019), had greater baseline sagittal malalignment (SVA 11.8 vs 5.0 cm, p = 0.001; PT 29.1° vs 21.9°, p = 0.016; and pelvic incidence [PI]-lumbar lordosis [LL] mismatch 29.6° vs 12.0°, p = 0.002), and had greater sagittal alignment correction following surgery (SVA reduction by 9.6 vs 2.8 cm, p < 0.001; and PI-LL mismatch reduction by 26.3° vs 10.9°, p = 0.003). RF occurred in 22.0% of patients with PSO (10 of the 11 fractures occurred adjacent to the PSO level), with rates ranging from 10.0% to 31.6% across centers. CC rods were used in 68% of PSO cases, including all with RF. Smoking, levels fused, and rod diameter did not differ significantly between patients with and without RF (p > 0.05). In cases including a PSO, the rate of RF was significantly higher with CC rods than with TA or SS rods (33% vs 0%, p = 0.010). On multivariate analysis, only PSO was associated with RF (p = 0.001, OR 5.76, 95% CI 2.01-15.8). CONCLUSIONS Rod fracture occurred in 9.0% of ASD patients and in 22.0% of PSO patients with a minimum of 1-year follow-up. With further follow-up these rates would likely be even higher. There was a substantial range in the rate of RF with PSO across centers, suggesting potential variations in technique that warrant future investigation. Due to higher rates of RF with PSO, alternative instrumentation strategies should be considered for these cases.
Adaboost Human Detection Based on a DSP Platform

Human detection is a task met in many applications such as surveillance & security, safe driving system, intelligent vehicles, etc. It is more complicated compared to the detection of car and other targets, due to the variety of poses and external appearance of human bodies. This paper presents an adaboost human detection algorithm and its implementation on a DSP platform. The detector uses haar-like features as classifiers. A cascade of boosted classifiers is obtained after extensive training of hundreds of positive and negative samples. Experimental results with the adaboost human detection algorithm are presented in the paper.
The Business Modelling Method for IT in Elderly Care

n increasing amount of people in the Netherlands needs homecare and elderly care, because of the ageing population. To keep up with these changes, the elderly care organizations must adapt their business models, especially to cope with the fast rising costs. The business modelling method (BMM) is a helpful tool to adapt the business models, but this recently developed method has not been fully tested yet and it is therefore not sure if it can justify investments (especially IT related) in those organizations. This research aims to evaluate the BMM. In this research, criteria were searched in the literature that can judge the applicability and usefulness of the BMM. A case study was performed in an elderly care organization to test the BMM in practice and finally, conclusions were drawn about the applicability and usefulness of the BMM. The results showed that the BMM is applicable in a case study in Dutch elderly care. It can also be useful enough to justify investments, but additions are needed to be fully certain of the best result. Keywordsmodel, business modelling method, elderly care
Treatment of spondyloarthropathy: the potential for agents other than TNF inhibitors

Purpose of reviewInhibitors of tumor necrosis factor (TNF) have demonstrated dramatic clinical efficacy in patients with spondyloarthropathy (SpA). However, not all patients respond, and some patients who initially improve, subsequently lose response. Therefore, there is still an unmet clinical need for additional therapies. Herein we describe the recent data on newer treatments for SpA patients. Recent findingsTreatments targeting various cytokines, cell surface molecules, and signaling molecules have been assessed. The effects of taregeting B cells with rituximab, T-cell costimulation with abatacept, and interleukin (IL)-6 with tocilizumab have been disappointing in ankylosing spondylitis (AS). Abatacept appears to have a modest effect in patients with psoriatic arthritis (PsA). Targeting IL-17 with secukinumab, IL-12/23 with ustekinumab, and phosphodiesterase 4 (PDE4) with apremilast may prove to be promising treatments for SpA. SummaryThere are several newer therapies that may emerge for SpA, particularly those targeting IL-17, IL-23/IL-12, and PDE4.
Toward the Use of NanoSQUIDs to Measure the Displacement of an NEMS Resonator

We discuss steps toward the readout of the position of a nanoelectromagnetic system (NEMS) beam resonator using a Nb nanosuperconducting quantum interference device (nanoSQUID). We describe our fabrication procedure for coupling the nanoSQUID and a suspended Al-coated Si3N4 NEMS resonator together by a combination of focused ion beam lithography and nanomanipulation. We discuss typical electrical characteristics of the integrated devices, and independent postfabrication atomic force microscope nanoindentation measurements of the elastic properties of the integrated resonator to estimate its natural frequencies of vibration. We compare and discuss the response of a nanoSQUID with current-carrying and superconducting screening (noncurrent carrying) modes of operation of the resonator