Miracle-dz/UniFAR-FTUs huggingface dataset:
Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection

Background Characterizing the prevalence and persistence of symptoms associated with COVID-19 infection following hospitalization and their impact is essential to planning post-acute community-based clinical services. This study seeks to identify persistent COVID-19 symptoms in patients 35 days post-hospitalization and their impact on quality of life, health, physical, mental, and psychosocial function. Methods and findings This prospective cohort study used the PROMIS® Instruments to identify symptoms and quality of life parameters in consecutively enrolled patients between March 22 and April 16, 2020, in New Jersey. The 183 patients (median age 57 years; 61.5% male, 54.1% white) reported persistent symptoms at 35 days, including fatigue (55.0%), dyspnea (45.3%), muscular pain (51%), associated with a lower odds rating general health (41.5%, OR 0.093 [95% CI: 0.026, 0.329], p = 0.0002), quality of life (39.8%; OR 0.116 [95% CI: 0.038, 0.364], p = 0.0002), physical health (38.7%, OR 0.055 [95% CI: 0.016, 0.193], p <0.0001), mental health (43.7%, OR 0.093 [95% CI: 0.021, 0.418], p = 0.0019) and social active role (38.7%, OR 0.095 [95% CI: 0.031, 0.291], p<0.0001), as very good/excellent, particularly adults aged 65 to 75 years (OR 8·666 [95% CI: 2·216, 33·884], p = 0·0019). Conclusions COVID-19 symptoms commonly persist to 35 days, impacting quality of life, health, physical and mental function. Early post-acute evaluation of symptoms and their impact on function is necessary to plan community-based services.
Model studies of the overall 5-endo-trig iodocyclization of homoallylic alcohols

Overall 5-endo-trig iodocyclizations of homoallylic alcohols, with a range of substitution patterns, leading to β-iodotetrahydrofurans are usually highly efficient and stereoselective when carried out in anhydrous acetonitrile in the presence of sodium hydrogen carbonate. Such cyclizations, which are not exceptions to Baldwin’s rules as they are electrophile-driven, appear to proceed via a well-ordered chair-like transition state. The iodine can be replaced by hydroxy, acetoxy and azide groups.
Low Frequency Acoustic Projectors for Underwater Applications

The effect of end cap and PZT materials on the acoustic performance of Cymbal transducer was attempted. Generally there are three frequency bands of interest for identification of the objects in shallow and deep water environments. These are from 1 kHz to 10 kHz; 10 kHz to 100 kHz and 100 kHz to 1 MHz. Currently there is an interest in the lower frequency band and that can be addressed by using cymbal transducers. Cymbal is class V flextensional transducer, it consists of cylindrical ceramic disk sandwiched between two cymbal shaped metal caps with hollow cavities. Cymbals are used as both sound projectors and receivers. Finite Element Analysis (FEA) ATILA code was used to analyze the performance of sound projector and receiver. Three typical ceramic disks and materials used as driving elements and end caps respectively were included in this study.
Effects induced by γ-irradiation and thermal treatment on the infrared spectra of ferrocene in its disordered state

Lattice, rotation and intramolecular vibrations of ferrocene, Fe(C5H5)2, crystallites of the factor group in the disordered phase are calculated using the correlation theorem based on group theory. The correlation between the species of the C 1 site symmetry occupied by cyclopentadienyl molecules and those of the factor group C 2 h of the crystal are calculated. The number of lattice vibrations of the cyclopentadienyl molecules is found to be 12, with active modes in Raman and infrared (IR) spectra. The same number of rotations for the cyclopentadienyl molecules is expected to be allowed in both spectra. The active number of intramolecular vibrations for the cyclo-pentadienyl molecules having D 5 molecular symmetry is expected to be 80 vibrations in both the Raman and the IR spectra. The effect of γ-irradiation with different doses and heat treatment at different temperatures on the IR spectra of ferrocene in the energy range 4000–200 cm−1 is discussed. A number of bands continuously shifted their position, and a decrease in intensity with increasing γ-dose is observed. New bands appeared in this spectral region for different annealing temperatures and different γ-doses. These changes are discussed in terms of intermolecular interactions between molecules within the unit cell.
Catalysed oxygenation of allylic hydroperoxides derived from qinghao (artemisinic) acid. Conversion of qinghao acid into dehydroginghaosu (artemisitene) and qinghaosu (artemisinin)

Photo-oxygenation of ginghao acid and its dihydro analogue provides allylic hydroperoxides which are converted either indirectly via the corresponding esters, or directly into dehydroginghaosu (artemisitene) and the antimalarial ginghaosu (artemisinin), by treatment with a catalytic amount of copper(II) trifluoromethanesulphonate with or without an iron(III) co-catalyst in dichloromethane-acetonitrile under oxygen.
Activity Comparison of MCM-41 and V-MCM-4 Catalysts for Ethanol Selective Oxidation and DRIFTS Analysis

The activity of a V-MCM-41 catalyst with a V/Si molar ratio of 0.04 was compared with the activity of a pure MCM-41 catalyst and some DRIFTS studies were performed in order to understand the mechanism of selective oxidation of ethanol. V-MCM-41 was found to be much more active than pure MCM-41, favouring the formation of high amounts of ethylene over 300°C. MCM-41, on the other hand, was found to favour the formation of acetaldehyde over ethylene at all studied temperatures. It was shown by reaction findings that over V-MCM-41, ethylene was produced mainly in the presence of gas phase oxygen whereas acetaldehyde was produced using the lattice oxygen even in the absence of gas phase oxygen. DRIFTS studies indicated the formation of acetaldehyde molecules from acetate-like surface species which were formed by the removal of a hydrogen atom from the ? -carbon of chemisorbed ethoxy species by the help of the lattice oxygen. On the other hand, removal of a hydrogen atom from the ? -carbon of the ethoxy species, in the presence of gas phase oxygen, resulted in the formation of vinyl-like surface species which then yielded ethylene molecules.
Enhancement of photocatalytic performance via a P3HT-g-C3N4 heterojunction

P3HT-g-C3N4 photocatalysts with high activity have been fabricated by assembling p-type P3HT particles on n-type g-C3N4 nanoplates via a ball milling method. The photocatalytic activity of the P3HT-g-C3N4 photocatalysts for the degradation of MB was 2 times higher than that of pure g-C3N4. The formation of a heterojunction interface of P3HT-g-C3N4 photocatalysts enhanced the separation efficiency of photogenerated electron–hole pairs and resulted in the enhancement of photocatalytic performance. The potential difference in the heterojunction is the main driving force for efficient charge separation and transfer.
Performance of different criteria for refractory myasthenia gravis

Defining refractory myasthenia gravis is important, as this can drive clinical decision making, for example, by escalating treatments in refractory individuals. There are several definitions of refractory myasthenia, and their performances have not been compared. Having valid and reliable criteria can help select patients in whom more aggressive treatments may be needed.
Aquatic food webs in deep temperate lakes: Key species establish through their autecological versatility

Microbial planktonic communities are the basis of food webs in aquatic ecosystems since they contribute substantially to primary production and nutrient recycling. Network analyses of DNA metabarcoding data sets emerged as a powerful tool to untangle the complex ecological relationships among the key players in food webs. In this study, we evaluated co‐occurrence networks constructed from time‐series metabarcoding data sets (12 months, biweekly sampling) of protistan plankton communities in surface layers (epilimnion) and bottom waters (hypolimnion) of two temperate deep lakes, Lake Mondsee (Austria) and Lake Zurich (Switzerland). Lake Zurich plankton communities were less tightly connected, more fragmented and had a higher susceptibility to a species extinction scenario compared to Lake Mondsee communities. We interpret these results as a lower robustness of Lake Zurich protistan plankton to environmental stressors, especially stressors resulting from climate change. In all networks, the phylum Ciliophora contributed the highest number of nodes, among them several in key positions of the networks. Associations in ciliate‐specific subnetworks resembled autecological species‐specific traits that indicate adaptions to specific environmental conditions. We demonstrate the strength of co‐occurrence network analyses to deepen our understanding of plankton community dynamics in lakes and indicate biotic relationships, which resulted in new hypotheses that may guide future research in climate‐stressed ecosystems.
Genetic variation in the TLL1 gene is not associated with fibrosis in patients with metabolic associated fatty liver disease

Metabolic associated fatty liver disease (MAFLD) is the most prevalent liver disease in Western nations, with high heritability. A recent study of Japanese patients with the disease suggested that TLL1 rs17047200 is associated with fibrosis; whether a similar association is observed in Caucasian patients with MAFLD is unknown. We investigated the association of the TLL1 rs17047200 polymorphism with liver fibrosis in a cohort of Caucasian patients with MAFLD (n = 728). We also investigated whether TLL1 expression is altered during liver injury in humans, in murine models of fibrosis, and in in-vitro. While TLL1 expression is upregulated in the liver of humans with MAFLD and in mice, the rs17047200 variant was not associated with fibrosis or any other histological features, or with hepatic TLL1 expression. In conclusion, the TLL1 rs17047200 variant is not a risk variant for fibrosis in Caucasian patients with MAFLD. However, TLL1 could be involved in the pathogenesis of liver fibrosis.
Algal toxicity of Talaromyces purpureogenus F pigments in heterotrophic cultivation mode

The present study deals with the impact of Talaromyces purpureogenus F pigments does on growth, photosynthetic activity of Parachlorella kessleri GB1. The reduction in growth and pigment contents (Chl a, Chl b, and carotenoids) was observed in the positive control (herbicide). However, the negative control and pigments doses did not differ significantly in pigments contents. The growth in pigment concentration 3 mg/mL was significantly higher than negative control this might be due to the left out medium content in the fungal pigments. This research provides an understanding of fungal pigments toxicity to aquatic organisms. The heterotrophic cultivation mode for algal toxicity results is rapid to assessments of toxicants.
Separation and Detection of Protein Charge Isoforms with a Combination of OFFGEL- and Labon-Chip Electrophoresis and Mass Spectrometry

Separation and analysis of charge heterogeneity in recombinant protein or monoclonal antibody (mAb) production is a prime quality control step in the biopharmaceutical industry. This step is often carried out by a combination of separation techniques followed by mass spectrometric detection. Two dimensional gel electrophoresis (2D-GE) is unrivalled in terms of resolution but is a tedious procedure. Here we present a combination of two easy methods that separate proteins in analogy to 2D-GE according to pI and molecular weight (kDa) with high reproducibility for the analysis of mAb's and recombinant proteins followed by mass spectrometry (MS) analysis. For the 1st dimension, OFFGEL electrophoresis was used. This method takes advantage of the impressive resolving power of immobilized pH gradient (IPG) gels but in contrast to conventional IEF delivers samples in liquid-phase. Fractions with charged isoforms in solution can directly be analyzed by MS. For the 2nd dimension, a highly sensitive microfluidic on-chip protein sizing method was employed. This method allows protein separation from 5 to 250 kDa and offers a sensitivity equivalent or better than silver staining and a linear dynamic range across four orders of magnitude. The charge heterogeneity in a mAb sample was evaluated under native conditions and with addition of a mild detergent (Tween-20). The difference in focusing patterns between the two conditions is clearly visualized with the Bioanalyzer protein assay. The combination of OFFGEL and lab-onchip protein analysis allows separation and identification of isoforms based on pI and molecular weight. Protein isoforms differing only by a few kDa in apparent molecular weight were successfully separated and enriched by OFFGEL electrophoresis for further downstream analysis by LC/MS-MS. The combination of OFFGEL, Bioanalyzer, and mass spectrometry is thus an efficient combination for detailed characterization of recombinant proteins such as mAb's.
Seeded Semibatch Emulsion Copolymerization of n-Butyl Acrylate and Methyl Methacrylate

The kinetics and polymer microstructure of the seeded semibatch emulsion copolymerization of n-BA/MMA were investigated in this work. Free monomer concentration was determined on-line by means of FT-Raman spectrosocopy. The kinetics, gel fraction, and molecular weight distribution were determined for several semibatch reactions of different monomer composition. The experiments show that, when the amount of MMA in the recipe was increased (from 90/10 to 50/50 n-BA/MMA by moles), the instantaneous conversion increased, whereas the gel content decreased and the sol molecular weight exhibited no defined trend. A mathematical model was used to analyze the experimental data.
Synthesis of Water‐Soluble Highly Two‐Photon Responsive [60]Fullerene‐Diphenylaminofluorene Chromophore Dyads

We have synthesized an amphiphilic donor‐acceptor type [60]fullerene‐diphenylaminofluorene (DPAF) containing oligo(ethylene glycol) moieties, denoted C60‐DPAF‐EGn. The hydrophobic C60‐DPAF moiety consisting of an electron‐donating diphenylaminofluorene unit and an electron‐accepting C60 cage shows large cross‐sections of two‐photon absorptivity (2PA) in the nanosecond region. The attachment of two hydrophilic oligo(ethylene glycol) segments on DPAF mainly increases water‐solubility of the corresponding chromophoric macromolecules that enhances their potential application in biomedical treatments. Here, we present the synthesis and self‐assembly study of these amphiphilic materials in aqueous solution. New C60‐DPAF‐EGn compounds were structurally characterized by various spectroscopic methods including, 1H‐NMR, 13C‐NMR, FT‐IR, and UV spectroscopies. In the vesicle formation investigation, UV‐visible absorption spectra, dynamic light scattering measurements, and transmission electron microscopy were used as primary methods for morphology characterization of molecular self‐assembly behavior of these amphiphilic [60]fullerene‐diphenylaminofluorene chromophore dyads.
A Fully Open-Source Approach to Intelligent Edge Computing: AGILE’s Lesson

In this paper, we describe the main outcomes of AGILE (acronym for “Adaptive Gateways for dIverse muLtiple Environments”), an EU-funded project that recently delivered a modular hardware and software framework conceived to address the fragmented market of embedded, multi-service, adaptive gateways for the Internet of Things (IoT). Its main goal is to provide a low-cost solution capable of supporting proof-of-concept implementations and rapid prototyping methodologies for both consumer and industrial IoT markets. AGILE allows developers to implement and deliver a complete (software and hardware) IoT solution for managing non-IP IoT devices through a multi-service gateway. Moreover, it simplifies the access of startups to the IoT market, not only providing an efficient and cost-effective solution for industries but also allowing end-users to customize and extend it according to their specific requirements. This flexibility is the result of the joint experience of established organizations in the project consortium already promoting the principles of openness, both at the software and hardware levels. We illustrate how the AGILE framework can provide a cost-effective yet solid and highly customizable, technological foundation supporting the configuration, deployment, and assessment of two distinct showcases, namely a quantified self application for individual consumers, and an air pollution monitoring station for industrial settings.
High-temperature oxidation of aniline to highly ordered polyaniline–sulfate salt with a nanofiber morphology and its use as electrode materials in symmetric supercapacitors

In this study, for the first time, aniline was oxidized by ammonium persulfate (APS) at higher temperatures without any protic acid, and APS acted as an oxidizing agent and a protonating agent. During the oxidation of aniline by APS, sulfuric acid formation occurred, and the sulfuric acid was incorporated into polyaniline (PANI) as a dopant. PANI–sulfate samples were characterized by IR spectroscopy, X-ray diffraction, and scanning electron microscopy techniques. In this methodology, a highly ordered PANI–sulfate salt (H2SO4) with a nanofiber morphology was synthesized. Interestingly, a PANI base was also obtained with a highly ordered structure with an agglomerated netlike nanofiber morphology. PANI–H2SO4 was used as an electrode material in a symmetric supercapacitor cell. Electrochemical characterization, including cyclic voltammetry (CV), charge–discharge (CD), and impedance analysis, was carried out on the supercapacitor cells. In this study, the maximum specific capacitance obtained was found to be 273 F/g at 1 mV/s. Scan rate from cyclic voltammetry and 103 F/g at 1 mA discharge current from CD measurement. Impedance measurement was carried out at 0.6 V, and it showed a specific capacitance of 73.2 F/g. The value of the specific capacitance and energy and power densities for the PANI–H2SO4 system were calculated from CD studies at a 5-mA discharge rate and were found to be 43 F/g, 9.3 W h/kg, and 500 W/kg, respectively, with 98–100% coulombic efficiency. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Clare Sarah Allely

It is being increasingly recognised that females with autism spectrum disorder (ASD) may exhibit superficial social skills which may help them to mask or hide their ASD symptomology. This ability can subsequently impact on the identification of the disorder. This ability to exhibit superficial social skills in order to mask ASD impairments is what is referred to as the ‘camouflage’ hypothesis. It is worth highlighting here that the capacity to ‘camouflage’ social impairments in social situations is increasingly recognised as being one of the key features of the female phenotype of ASD. This paper will explore some of the studies which have investigating camouflaging behaviours in females with ASD. The studies identified in the systematic review by Allely (2019) highlighted that there exists relatively little empirical research exploring this main feature of the female phenotype of ASD.
Multi-channel transcranial temporally interfering stimulation (tTIS): application to living mice brain

Objective. Transcranial temporally interfering stimulation (tTIS) is a noninvasive neuromodulation method, which has been reported to be able to affect the activity of small neuronal populations. To pinpoint smaller regions of the brain, a multi-channel tTIS strategy is proposed with larger numbers of electrodes and multiple sets of interfering fields. Approach. First, a computational model is adopted to prove the concept of multi-channel tTIS theoretically. Besides, animal experiments are implemented to activate motor cortex neurons in living mice and different frequencies are attempted. Finally, to better understand the envelope modulation properties of the two applied fields, tissue phantom measurement is conducted. Main results. The focality of six-channel (six electrode pairs) tTIS is increased by 46.7% and 70.2% respectively, compared with that of single-channel tTIS when maximal amplitude value drops by 3 dB and 6 dB in a numerical computation experiment. Furthermore, the focality of multi-channel tTIS is less sensitive to the electrode position. Confirmed with the myoelectricity signal, the movement frequencies of the contralateral forepaw are consistent with the corresponding difference frequencies. What is more, compared to single-channel (one electrode pair) tTIS with multi-channel (three electrode pairs) tTIS, the intensity of multi-channel tTIS stimulation is decreased by 28.5% on average in animal experiments. The c-fos-positive neurons of the target region are significantly higher than that of the non-target region. Results of the modulated envelope distribute around the whole region and its amplitude reaches a maximum at the interfering region. Significance. Both computational modeling and animal experiment validate the feasibility of the proposed multi-channel tTIS strategy and confirm that it can enhance focality and reduce scalp sensation.
Secondary Formation and the Smoky Mountain Organic Aerosol: An Examination of Aerosol Polarity and Functional Group Composition During SEAVS

Size-resolved particle samples were collected in the Smoky Mountains at Look Rock, TN, during the Southeastern Aerosol and Visibility Study (SEAVS) July−August 1995 and analyzed directly by Fourier transform infrared (FTIR) spectroscopy for functional group and chemical bond information. Twenty-eight samples were also gently rinsed in hexane, acetone, and water and reanalyzed after each rinse. Direct FTIR analyses of substrates rinsed with solvents enabled separation by polarity and identification of sulfur-containing organics even though samples were too small for traditional extraction and analysis (approximately 10−15 μg). The submicron organic aerosol was predominantly polar. Most of the nonpolar material, including aliphatic carbon and various minerals, was concentrated in particles greater than 1.0 μm and is most likely from primary biogenic and geogenic emissions, such as plant waxes and windblown soil dust. Unlike Los Angeles, carbonyl size distributions were unimodal and usually peaked in the 0.5.