Miracle-dz/UniFAR-FTUs huggingface dataset:
Spectroscopic observations of PHz G237.01+42.50: A galaxy protocluster at z=2.16 in the Cosmos field

The Planck satellite has identified more than 2,000 protocluster candidates with extreme star formation rates (SFRs). Here, we present the spectroscopic identification of a Planck-selected protocluster located in the Cosmos field, PHz G237.01+42.50. PHz G237.01+42.50 contains a galaxy overdensity of 31 spectroscopically identified galaxies at z'2.16 (significant at 5.4σ) in a 10′×11′ region. The overdensity contains two substructures or protoclusters at <z> '2.16 and 2.195 with estimated halo masses at z = 0 of ∼5–6×1014 M , roughly consistent with Virgo-type clusters. The overdensity total SFR, ∼4000 M yr−1, is higher than predicted by simulations but much smaller than the SFR derived from the Planck data (i.e., 10,173 M yr−1). The analysis of the Herschel data in the field, in combination with the available ancillary data, shows that such a difference is due to an effect of source alignment along the line of sight that produces a 5σ overdensity of red Herschel sources in the field. We analyze the members’ ultraviolet (UV) spectra and UV-far-infrared spectral energy distributions to derive their SFR, stellar mass, and metallicity. Galaxy members include blue star-forming galaxies and Active galactic nuclei (AGN) with SFRs and stellar masses consistent with the main sequence. Active galactic nuclei, identified through optical spectroscopy or X-ray data, represent a significant fraction (20±10%) of all members of the protocluster at z = 2.16, and they are powerful enough to produce radiative feedback. The core of this protocluster, besides being denser, includes members that are, on average, more massive and star-forming and contains a larger fraction of AGN and Herschel-detected galaxies than the full sample, suggesting an environmental effect on galaxy growth. A comparison between PHz G237.01+42.50 and other protoclusters in the literature at similar redshifts reveals some common traits and differences that reflect both observational biases and a diversity in intrinsic properties that is not yet fully understood.
The major cardiovascular events of febuxostat versus allopurinol in treating gout or asymptomatic hyperuricemia: a systematic review and meta-analysis.

BACKGROUND To evaluate the major cardiovascular events of febuxostat compared to allopurinol for the treatment of gout or asymptomatic hyperuricemia. METHODS Relevant studies published until August 15, 2020 were identified by a systematic search of the PubMed and Wiley Online Library databases. Any controlled clinical trial, randomised controlled trial (RCT), retrospective cohort study or open label trial (OLT) comparing febuxostat in patients with gout or hyperuricemia with allopurinol. The quality of all identified studies was assessed based on Cochrane Collaboration's risk of bias tool. Odds ratios (OR) were calculated with random effects and reported with corresponding 95% confidence intervals (CI). RESULTS Eighteen studies were ultimately included in the analysis, among them 6 articles mentioned serum uric acid (sUA) level before and after treatment, 14 articles mentioned major cardiovascular events, 5 articles mentioned cardiovascular death, 6 articles mentioned skin reactions, 6 articles mentioned musculoskeletal and connective tissue signs and symptoms, 4 articles mentioned joint-related signs and symptoms, 6 articles mentioned upper respiratory infection, 5 articles mentioned gastrointestinal reaction and 7 articles mentioned all-cause mortality. The febuxostat group showed significantly lower sUA levels than allopurinol group (MD =-0.83, 95% CI: -1.22 to -0.44, P<0.0001, I2 =98%). There was no markedly difference between the febuxostat and allopurinol (OR 1.01, 95% CI: 0.83 to 1.23, P=0.84, I2 =95%) in the major cardiovascular events. The occurrence of skin reactions of febuxostat was significantly fewer than allopurinol (OR 0.55, 95% CI: 0.42 to 0.73, P<0.0001, I2 =49%). Regarding to occurrence of CV death, musculoskeletal and connective tissue signs and symptoms, febuxostat group was higher than allopurinol group. However, among patients with gout or hyperuricemia, treatment with febuxostat resulted in other adverse reactions, including all-causes mortality similar to those associated with allopurinol. CONCLUSIONS The limitation of the study was the included studies show high heterogeneity in regard to their design. There was no difference in the incidence of major cardiovascular events between febuxostat and allopurinol, and febuxostat was better in lowering uric acid and has less adverse skin reactions than allopurinol, but the risk of CV death of febuxostat was higher than allopurinol.
Reconstructing and grounding narrated instructional videos in 3D

Narrated instructional videos often show and describe manipulations of similar objects, e.g., repairing a particular model of a car or laptop. In this work we aim to reconstruct such objects and to localize associated narrations in 3D. Contrary to the standard scenario of instance-level 3D reconstruction, where identical objects or scenes are present in all views, objects in different instructional videos may have large appearance variations given varying conditions and versions of the same product. Narrations may also have large variation in natural language expressions. We address these challenges by three contributions. First, we propose an approach for correspondence estimation combining learnt local features and dense flow. Second, we design a two-step divide and conquer reconstruction approach where the initial 3D reconstructions of individual videos are combined into a 3D alignment graph. Finally, we propose an unsupervised approach to ground natural language in obtained 3D reconstructions. We demonstrate the effectiveness of our approach for the domain of car maintenance. Given raw instructional videos and no manual supervision, our method successfully reconstructs engines of different car models and associates textual descriptions with corresponding objects in 3D.
Renovation of EdgeCloudSim: An Efficient Discrete-Event Approach

Due to the growing popularity of the Internet of Things, edge computing concept has been widely studied to relieve the load on the original cloud and networks while improving the service quality for end-users. To simulate such a complex environment involving edge and cloud computing, EdgeCloudSim has been widely adopted. However, it suffers from certain efficiency and scalability issues due to the ignorance of the deficiency in the originally adopted data structures and maintenance strategies. Specifically, it generates all events at beginning of the simulation and stores unnecessary historical information, both result in unnecessarily high complexity for search operations. In this work, by fixing the mismatches on the concept of discrete-event simulation, we propose enhancement of EdgeCloudSim which improves not only the runtime efficiency of simulation, but also the flexibility and scalability. Through extensive experiments with statistical methods, we show that the enhancement does not affect the expressiveness of simulations while obtaining 2 orders of magnitude speedup, especially when the device count is large.
Extensive Horizontal Gene Transfer within and between Species of Coagulase-Negative Staphylococcus

Abstract Members of the gram-positive bacterial genus Staphylococcus have historically been classified into coagulase-positive Staphylococcus (CoPS) and coagulase-negative Staphylococcus (CoNS) based on the diagnostic presentation of the coagulase protein. Previous studies have noted the importance of horizontal gene transfer (HGT) and recombination in the more well-known CoPS species Staphylococcus aureus, yet little is known of the contributions of these processes in CoNS evolution. In this study, we aimed to elucidate the phylogenetic relationships, genomic characteristics, and frequencies of HGT in CoNS, which are now being recognized as major opportunistic pathogens of humans. We compiled a data set of 1,876 publicly available named CoNS genomes. These can be delineated into 55 species based on allele differences in 462 core genes and variation in accessory gene content. CoNS species are a reservoir of transferrable genes associated with resistance to diverse classes of antimicrobials. We also identified nine types of the mobile genetic element SCCmec, which carries the methicillin resistance determinant mecA. Other frequently transferred genes included those associated with resistance to heavy metals, surface-associated proteins related to virulence and biofilm formation, type VII secretion system, iron capture, recombination, and metabolic enzymes. The highest frequencies of receipt and donation of recombined DNA fragments were observed in Staphylococcus capitis, Staphylococcus caprae, Staphylococcus hominis, Staphylococcus haemolyticus, and members of the Saprophyticus species group. The variable rates of recombination and biases in transfer partners imply that certain CoNS species function as hubs of gene flow and major reservoir of genetic diversity for the entire genus.
Draft Genome Sequence of Salegentibacter sp. Strain BDJ18, a Plankton-Associated Bacterium in the Northeast Atlantic Ocean

Salegentibacter sp. strain BDJ18 was isolated from a plankton-associated seawater sample from the northeast Atlantic Ocean. We report its draft genome assembly, which includes genes potentially important for microbial interactions in the marine environment. ABSTRACT Salegentibacter sp. strain BDJ18 was isolated from a plankton-associated seawater sample from the northeast Atlantic Ocean. We report its draft genome assembly, which includes genes potentially important for microbial interactions in the marine environment.
Synthesis of zinc oxide/graphene oxide nanocomposite material for antibacterial application

In this study, graphene oxide (GO) was prepared by a modified Hummers' method and ZnO/GO was synthesised by coprecipitation. The structural and morphological properties of ZnO/GO nanocomposite were characterised by using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM), Brunauer–Emmett–Teller (BET) method, and Raman spectroscopy. The characterisation results show that ZnO nanoparticles with a mean size of 14–26 nm were synthesised and randomly decorated on the surfaces and edges of GO sheets. In addition, the antimicrobial activities of GO and ZnO/GO were tested against bacteria – Escherichia coli (E. coli). The test results reveal that the antibacterial activity at low loading of the ZnO/GO nanocomposite was higher than that of GO on E. coli.
Transposed and substituted letter effects across reading development: A longitudinal study.

Reading development involves several changes in orthographic processing. A key question is, "how does the coding of letters develops in children learning to read? " Masked priming effects of transposition and substitution primes have been taken to index the importance of letter position and identity coding. Somewhat contradicting results for developing readers have led to opposing theories. Here, we present new evidence from a large longitudinal study with over 100 children from grade 2 to 4. We investigate three different issues concerning transposition and substitution priming: (a) comparing priming both against an all-different and an identity baseline, (b) testing priming effects for nonword targets, and (c) taking into account interindividual differences in orthographic knowledge. The analyses of the longitudinal data show, respectively, (a) an increase of priming effects over development in comparison to both baselines, (b) identity priming for nonword targets in the elementary school years, and (c) an additional impact of orthographic knowledge on priming effects for word, but not nonword, targets that is similar to the effect of grade. Taken together, our examination suggests that letter identity is coded relatively strictly, whereas letter position is coded relatively flexibly already early in reading development for words, but not for nonwords. We discuss how this pattern fits with different developmental models of orthographic processing. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
Proximity labeling and other novel mass spectrometric approaches for spatiotemporal protein dynamics

ABSTRACT Background Proteins are highly dynamic and their biological function is controlled by not only temporal abundance changes but also via regulated protein–protein interaction networks, which respond to internal and external perturbations. A wealth of novel analytical reagents and workflows allow studying spatiotemporal protein environments with great granularity while maintaining high throughput and ease of analysis. Areas covered We review technology advances for measuring protein–protein proximity interactions with an emphasis on proximity labeling, and briefly summarize other spatiotemporal approaches including protein localization, and their dynamic changes over time, specifically in human cells and mammalian tissues. We focus especially on novel technologies and workflows emerging within the past 5 years. This includes enrichment-based techniques (proximity labeling and crosslinking), separation-based techniques (organelle fractionation and size exclusion chromatography), and finally sorting-based techniques (laser capture microdissection and mass spectrometry imaging). Expert opinion Spatiotemporal proteomics is a key step in assessing biological complexity, understanding refined regulatory mechanisms, and forming protein complexes and networks. Studying protein dynamics across space and time holds promise for gaining deep insights into how protein networks may be perturbed during disease and aging processes, and offer potential avenues for therapeutic interventions, drug discovery, and biomarker development.
Hamiltonian-Driven Adaptive Dynamic Programming With Approximation Errors

In this article, we consider an iterative adaptive dynamic programming (ADP) algorithm within the Hamiltonian-driven framework to solve the Hamilton–Jacobi–Bellman (HJB) equation for the infinite-horizon optimal control problem in continuous time for nonlinear systems. First, a novel function, “min-Hamiltonian,” is defined to capture the fundamental properties of the classical Hamiltonian. It is shown that both the HJB equation and the policy iteration (PI) algorithm can be formulated in terms of the min-Hamiltonian within the Hamiltonian-driven framework. Moreover, we develop an iterative ADP algorithm that takes into consideration the approximation errors during the policy evaluation step. We then derive a sufficient condition on the iterative value gradient to guarantee closed-loop stability of the equilibrium point as well as convergence to the optimal value. A model-free extension based on an off-policy reinforcement learning (RL) technique is also provided. Finally, numerical results illustrate the efficacy of the proposed framework.
Background Modelling and Subtraction on Daubechies Wavelet Decomposition Using Object Detection

: The project presents moving object detection based on background subtraction under Daubechies wavelet transform domain for video surveillance system. The object detection in the frequency domain will be approached to segment objects from foreground with an absence of background noise. Initially, it starts with background initialization by choosing start frame or taking initial few frames with the approximate median method. Then, DWT is applied to both current and initialized background frame generates sub-bands of low and high frequencies. Frame differencing will be done in this sub-bands followed by edge map creation and image reconstruction. In order to remove some unwanted pixels, morphological erosion and dilation operation is performed for object edge smoothness. The proposed approach has some advantages of background noise insensitiveness and invariant to varying illumination or lighting conditions. It also involves background updating model based on the current frame and previous background frame pixels comparisons. After the object detection, the performance of method will be measured (between frame ground truth and obtained result) through metrics such as sensitivity, accuracy, correlation and peak signal to noise ratio. This object detection also helps to track the detected object using connected component analysis. The use of proposed methodologies for effective object detection have better accuracy and with less processing time consumption rather than existing methods.
Patient-Reported Outcome Scores and Rate of Return to Sport After Hip Arthroscopic Surgery: A Sex-Based Comparison in Professional and Collegiate Athletes

Background: No studies have compared outcomes and return to sport (RTS) after hip arthroscopic surgery between matched groups of male and female athletes with a minimum 2-year follow-up. Purpose: (1) To report minimum 2-year postoperative patient-reported outcome (PRO) scores and the RTS rate for elite female athletes undergoing hip arthroscopic surgery for femoroacetabular impingement (FAI) and (2) to compare clinical results with a matched control group of elite male athletes. Study Design: Cohort study; Level of evidence, 3. Methods: Data on all consecutive female athletes who underwent primary hip arthroscopic surgery performed at our institution between March 2009 and July 2018 were collected. Patients were eligible if they underwent hip arthroscopic surgery for labral tears or FAI and participated in collegiate or professional athletics within 1 year of surgery. Minimum 2-year postoperative PRO scores were collected for the modified Harris Hip Score (mHHS), Nonarthritic Hip Score (NAHS), Hip Outcome Score–Sport-Specific Subscale (HOS-SSS), and visual analog scale (VAS) for pain as well as RTS status. The percentages of patients achieving the minimal clinically important difference (MCID) and patient acceptable symptomatic state were recorded. These patients were matched to elite male athletes for comparison. Results: A total of 73 female hips were included, with a mean follow-up of 65.1 ± 27.9 months. They demonstrated a significant improvement from preoperatively to latest follow-up on the mHHS, NAHS, HOS-SSS, and VAS (P < .05). When outcomes were compared with a control group of male athletes, female athletes demonstrated lower preoperative scores, similar postoperative scores, and a significantly greater magnitude of improvement (delta value) on the mHHS, NAHS, and VAS. Female athletes also achieved the MCID at higher rates than did male athletes for the HOS-SSS (85.1% vs 70.0%, respectively; P = .035) and NAHS (79.1% vs 62.9%, respectively; P = .037). RTS rates among patients who attempted were similar between the 2 groups (female: 75.4%; male: 83.1%; P = .409). Conclusion: Elite female athletes undergoing primary hip arthroscopic surgery for FAI demonstrated a significant improvement in PRO scores and a high RTS rate. Female athletes exhibited a greater improvement in PRO scores (mHHS, NAHS, VAS) and achieved the MCID (HOS-SSS, NAHS) at higher rates compared with a control group of male athletes.
Gender and pandemic perception: analyzing perceived risk and fear among Brazilian women

ABSTRACT Objective The World Health Organization has warned of the importance of looking at the pandemic from a gender perspective since biological, social, and cultural aspects can produce differences in the way women and men experience the ongoing pandemic situation. This study aimed to investigate Brazilian women’s perception of COVID-19 concerning the susceptibility to infection, the severity of COVID-19, and the collective behavior in response to pandemic risks. It also sought to examine the COVID-19 level of perceived fears by the level of fear across specific COVID-19 fears, such as the risk of infection and the threat posed to life. Methods The sample consisted of 5527 Brazilian women aged between 18 and 74 years (mean age = 41, SD = 13.5) recruited from an online cross-sectional survey conducted in Brazil. The analysis addressed questions about the chance of COVID-19 infection, the impact on daily activities in case of infection, the threat to life posed by COVID-19, and the collective behavior in the pandemic context. In addition, the fear of COVID-19 was assessed using the Fear of COVID-19 Scale (FCV-19S). Results Women’s age and personal conditions, particularly those related to family and domestic life, showed association with the perceived susceptibility to infection and the severity of COVID-19. The higher the perceived susceptibility and severity, the greater the fear level. The fear level was also higher among women whose perception was that people were ignoring the pandemic risks. Conclusion This study provides insight into Brazilian women’s perception of COVID-19 and their fear level during the pandemic’s early stages. Our findings can increase the understanding of the adverse consequences caused by the COVID-19 pandemic on women, assisting in the strategic planning of public policies.
Downregulation of miR-519d-3p is Associated with Poor Outcomes and Facilitates Tumor Progression in Papillary Thyroid Cancer by Regulating FOXQ1

Abstract MicroRNA-519d-3p (miR-519d-3p) has emerged as a tumor suppressor in several human cancers. But whether miR-519d-3p is involved in papillary thyroid cancer (PTC) remains elusive. In this study, we investigated the potential relevance of miR-miR-519d-3p in PTC. A retrospective study of 119 PTCs was carried out. The RT-qPCR analysis was used to measure the expression of miR-519d-3p and FOXQ1 in PTC tissues and cells. Chi-square test, Kaplan–Meier curve analysis, and multivariate Cox regression analyses were performed to assess the clinical and prognostic value of miR-519d-3p in PTC. Then cellular experiments were used to explore its biological effects on PTC cells. Finally, the Pearson correlation coefficient, dual-luciferase reporter assay, and rescue experiments were used to analyze the association between miR-519d-3p and FOXQ1. miR-519d-3p was significantly downregulated in PTC tissues and cell lines. The decreased expression of miR-519d-3p was associated with reduced overall survival and progression-free survival of patients. The proliferative, migratory, and invasive abilities of cells were blocked or elevated after upregulation or downregulation of miR-519d-3p, while FOXQ1 reversed these cellular behaviors caused after upregulation or knockdown of miR-519d-3p. In conclusion, miR-519d-3p was downregulated in PTC and associated with OS and PFS of patients. MiR-519d-3p may be a tumor-inhibiting miRNA in PTC, and that miR-519d-3p/FOXQ1 axis mediated PTC tumor progression from cell proliferation, migration, and invasion in PTC cells.
Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs

Rattus norvegicus (Norway rat) is the main reservoir host of pathogenic Leptospira, the causative agent of leptospirosis, in urban environments. Pathogenic Leptospira forms biofilms in the environment, possibly contributing for bacterial survival and maintenance. Nonetheless, biofilms have not yet been studied in natural animal reservoirs presenting leptospiral renal carriage. Here, we described biofilm formation by pathogenic Leptospira inside the renal tubules of R. norvegicus naturally infected and captured in an urban slum endemic for leptospirosis. From the 65 rats carrying Leptospira in their kidneys, 24 (37%) presented biofilms inside the renal tubules. The intensity of leptospiral colonization in the renal tubules (OR: 1.00; 95% CI 1.05–1.1) and the type of occlusion pattern of the colonized renal tubules (OR: 3.46; 95% CI 1.20–9.98) were independently associated with the presence of Leptospira biofilm. Our data showed that Leptospira interrogans produce biofilms during renal chronic colonization in rat reservoirs, suggesting a possible role for leptospiral biofilms in the pathogenesis of leptospirosis and bacterial carriage in host reservoirs.