Miracle-dz/UniFAR-FTUs huggingface dataset:
Relationship of umbilical coiling index and cord twist direction with adverse perinatal outcomes

Background: The main objectives of this study were to examine - (1) relationship of pregnancy-related factors (maternal age, gestational diabetes mellitus, pregnancy-induced hypertension, oligohydramnios, small for gestational age (GA), and fetal gender) and postnatally measured umbilical coiling index (UCI); (2) association of UCI and cord twist directions with the following adverse perinatal outcomes, meconium staining of amniotic fluid, non-reassuring FHR on CTG, low Apgar score (<7) at one and five minutes, low birth weight, and NICU admission.Methods: The inclusion criteria were singleton live-birth pregnancy with GA > 34 weeks. The cases were categorized in hypocoiled (UCI <10th percentile), hypercoiled (UCI >90th percentile) and normocoiled groups. To study relationship of pregnancy-related factors and UCI, multivariate logistic regression was used; whereas bivariate analysis was used to study impact of UCI on various adverse perinatal outcomes. UCI was measured by a single observer.Results: In total, 100 subjects were enrolled. The mean UCI was 0.268 (SD = 0.13; 10th percentile = 0.139; 90th percentile = 0.410) coils/cm. Pregnancy-related factors had non-significant relationship with UCI. For adverse perinatal outcomes, only the non-reassuring/abnormal FHR patterns were significantly associated with hypercoiled groups (OR = 4.5; CI =1.15 - 17.58). Both cord directions had almost equal distribution without any significant difference in outcomes; however, anticlockwise twisted cords were found to have significantly high UCI.Conclusions: No significant relationship was observed with pregnancy-related factors and UCI. However, it was observed that hypercoiled cords had significant association with non-reassuring/abnormal FHR patterns on CTG.
A Influência do fortalecimento do quadril sobre a ativação muscular e o controle postural dinâmico na instabilidade crônica do tornozelo (ICT)

Objetivo: Analisar a influencia do fortalecimento da musculatura abdutora e rotadora lateral do quadril sobre a ativacao muscular (EMG) e o controle postural dinâmico em individuos com ICT. Metodologia: Amostra composta por 32 individuos com historico de entorse de tornozelo, ha mais de 6 meses, dividida em 3 grupos: exercicios tradicionais de tornozelo (GET); exercicios tradicionais de tornozelo e fortalecimento do quadril (GFQT) e o grupo controle (GC). Foram observados o Controle Postural Dinâmico (SEBT), a ativacao muscular (EMG) durante o SEBT e a funcionalidade do tornozelo pre, 4 semanas e 8 semanas, apos um protocolo de fortalecimento do tornozelo e exercicios proprioceptivos (GET), associado ao fortalecimento do quadril (GFQT). Os dados foram analisados no SPSS (20.0) pelo teste de ANOVA (two-way) e post-hoc de Bonferroni, para avaliar as diferencas entre os grupos, considerando um nivel de significância de 5% para todas as comparacoes. Resultados: Houve diferencas significativas entre as avaliacoes no controle postural dinâmico, ativacao muscular e na funcionalidade do GET e GFQT (P 0,05). Conclusao: um protocolo de 8 semanas de exercicios proprioceptivos e fortalecimento muscular do tornozelo promoveram melhora do controle postural dinâmico e da funcionalidade do tornozelo em individuos com ICT, independente do fortalecimento dos abdutores e rotadores laterais do quadril.
Hip Fractures in Older Adults in Ontario, Canada—Monthly Variation, Insights, and Implications

Background In older adults, hip fractures have been described to peak in cooler months. Seasonal differences in patient vulnerability to fracture and social/behavioural factors might contribute to these trends. Methods Using linked health-care databases in Ontario Canada, we examined monthly variation in hip fracture hospitalizations in those > 65 years (2011–2015). We stratified results by age category (66–79, ≥80 years). We then examined for variation in the demographic and comorbidity profiles of patients across the months, and as an index of contributing social/behavioural factors, noted variation in health-care behaviours. Results There were 47,971 and 52,088 hospitalizations for hip fracture in those 66–79, and ≥80 years, respectively. There was strong seasonality in fractures in both groups. Peaks occurred in October and December when patients appeared most vulnerable. Rates fell in the summer in those 66–79 years, and in the late winter in those ≥80 years (when health-care utilization also declined). A smaller peak in fractures occurred in May in both groups. Conclusions Hip fractures peak in the autumn, early winter, and spring in Canada. A dip in fractures occurs in the late winter in the oldest old. Environmental factors might play a role, but seasonal vulnerability to fracture and winter isolation might also be influential.
Efficacy and Safety of NaoShuanTong Capsule in the Treatment of Ischemic Stroke: A Meta-Analysis

Background: Ischemic stroke (IS) is a leading cause of death and long-term disability worldwide. The NaoShuanTong capsule (NSTC), a traditional Chinese patent medicine, has been extensively used in the treatment of stroke in China. However, the clinical efficacy and safety of this treatment has not been statistically and systematically verified by any comprehensive pooled analysis. We therefore performed a meta-analysis to evaluate the efficacy and safety of NSTC in the treatment of IS. Methods: Randomized controlled trials (RCTs) of NSTC in the treatment of IS conducted before September 2018 were retrieved from five databases, according to specific inclusion and exclusion criteria. Two investigators independently reviewed the included studies and extracted relevant data. The methodological quality of the included studies was assessed using criteria from the Cochrane Handbook, and analyzed using Review Manager 5.3 software. Results: Thirteen RCTs comprising a total of 1,360 participants were included in this study. NSTC was shown to significantly improve the overall response rate (OR = 3.04, 95% CI [1.76, 5.26], P < 0.00001), and neurological function (NSTC increased Modified Barthel Index (MD = 8.15, 95% CI [3.79, 12.52], P = 0.0005), Functional Independence Measure (MD = 29.61, 95% CI [10.11, 49.10], P = 0.003) and European Stroke Scale scores (MD = 8.51, 95% CI [7.00, 10.01], P = 0.03). In addition, NSTC significantly increased serum adiponectin level (MD = 0.66, 95% CI [0.23, 1.08], P = 0.002). Moreover, NSTC reduced atherosclerotic plaque area (MD = -2.24, 95% CI [-4.02, -0.46], P = 0.01) and intima-media thickness (MD = -0.09, 95% CI [-0.13, -0.05], P < 0.0001). However, there was no significant difference between NSTC treatment and conventional therapy with respect to Fugl-Meyer Assessment score (MD = 10.59, 95% CI [-1.78, 22.96], P = 0.09) or Crouse score (MD = -0.78, 95% CI [-1.79, -0.22], P = 0.13). Conclusions: The results of this meta-analysis showed that NSTC exhibits efficacy in the treatment of cerebral infarction. NSTC can improve the overall response rate and neurological function, increase blood adiponectin, reduce neurological deficits, and decrease atherosclerotic plaque area.
Handgrip strength is associated with hippocampal volume and white matter hyperintensities in major depression and healthy controls: a U.K. Biobank study.

OBJECTIVES Emerging evidence suggests that handgrip strength (a proxy for muscular fitness) is associated with better cognitive performance in people with major depressive disorder (MDD). The underlying processes are unclear, although hippocampal volume (HCV) reductions and white matter hyperintensities (WMHs) have been implicated. Therefore, we investigated the associations between handgrip strength and various brain region volumes and WMHs in MDD and healthy controls (HCs). METHODS This study is a cross-sectional analysis of handgrip strength and neuroimaging data from the U.K. Biobank. Generalised linear models were used to assess the relationship between grip strength and grey matter, white matter, total brain volume, left and right hippocampus volume and WMHs in MDD and HCs, adjusting for age, sex, education and bodyweight. RESULTS The sample included 527 people with MDD (54.3±7.3 years, 37.2% male) and 1764 HCs (56.6±7.2 years, 53% male). In MDD, stronger handgrip was significantly associated with increased left (Coefficient±S.E= 108.1±27.6, t=3.92) and right (76.8±30.4, t=2.53) HCV. In HCs, only right HCV related to handgrip strength (44.8±18.1, t=2.47). Interaction analyses found stronger associations between grip strength and HCV in MDD compared to HCs, for both hippocampal regions. Stronger handgrip was associated with reduced WMHs in people with MDD (-0.24±0.07, t=-3.24) and HCs (-0.11±0.04, t=-2.47). Maximal handgrip strength was not associated with grey matter, white matter or total brain volumes in either group. CONCLUSIONS Stronger grip strength is associated with greater left and right HCV and reduced WMHs in MDD. Future research should investigate directionality and consider if interventions targeting strength/muscular fitness can improve brain health and reduce the neurocognitive abnormalities associated with MDD.
Transurethral resection of bladder tumour as day-case surgery: Evidence of effectiveness from the UK Getting it Right First Time (GIRFT) programme

We aimed to investigate outcomes of transurethral resection of bladder tumour (TURBT) surgery when performed as day-case surgery compared to outcomes for patients who stayed ⩾ 1 night in hospital. Data were taken from the 2017–2018 Hospital Episodes Statistics data set, which contains data for all TURBT procedures conducted within the National Health Service in England. Data were categorised as those seen as day-cases and those that involved an overnight stay. Of 19,383 TURBT procedures, 3466 (17.9%) were classified as day-case surgery. Those who had an overnight stay were significantly older and were significantly more likely to be male, and have significantly greater frailty and comorbidity. After adjusting for confounders, those with an overnight stay had significantly poorer outcomes with regard to mortality and emergency readmission rates. Comparing trusts with the highest and lowest rate, of overnight stay, there were no differences in the profiles of the patients seen or in outcomes. Patients undergoing TURBT as day-case surgery have at least as good outcomes as those having an overnight stay. Investigation of the technical quality of the tumour resection, patient experience and quality of life after day-case surgery for TURBT would provide further insight. Evidence level: 2b
Unusual Presentation of Splenogonadal Fusion in a 7-Month-Old Male Infant

Introduction: Splenogonadal fusion is a rare congenital anomaly characterized with anomalous fusion of the spleen and the gonad or mesonephric derivatives. Herein, we report the case of a 7-month-old boy with unusual presentation of splenogonadal fusion. Case Presentation: A 7-month-old boy was brought to the Urology Clinic, Imam Reza Hospital, Mashhad, Iran, by his parents complaining of a painless palpable scrotal mass with a sudden increase in the size after a respiratory infection. The patient underwent surgery with a suspicion of testicular malignant tumors. However, pathologic study revealed a benign mass with splenic origin. Conclusion: Preoperative diagnosis of splenogonadal fusion is almost impossible and most cases undergo an unnecessary orchiectomy, especially when the clinical presentation resembles a primary testicular neoplasm. Although surgery is necessary to remove the benign splenic tissue as well, proper knowledge and consideration along with appropriate imaging studies and histopathological examination contribute in avoiding an unnecessary orchiectomy.
A Comparative Analysis of Work-Life Balance in Intercollegiate Athletic Graduate Assistants and Supervisors

A COMPARATIVE ANALYSIS OF WORK-LIFE BALANCE IN INTERCOLLEGIATE ATHLETIC GRADUATE ASSISTANTS AND SUPERVISORS By SHAINA ERVIN The sport industry is a popular and competitive career field with employees drawn to work in a dynamic, yet often untraditional work environment. The challenge of achieving work-life balance has received considerable study in sport, as employees often find a conflict in balancing their job and other life responsibilities, such as family (work-family conflict) and outside activities. This study introduces a new area of potential conflict (work-extracurricular conflict), the outside activities that may be neglected due to a job, which may impact employees. This area may be especially pertinent to a younger segment of the industry which has not been studied, graduate assistants who work in athletic departments while continuing their education. The purpose of this exploratory study was to assess work-life balance in graduate assistants (GAs) and their supervisors by comparing their levels of work-family conflict, work-extracurricular conflict, job satisfaction, and life satisfaction. Secondly, the study introduced the workextracurricular conflict construct. Data were collected from GAs and supervisors (N = 47) working in five Division I university athletic departments. Descriptive statistics and ANOVA revealed significant differences between GAs’ and supervisors’ job satisfaction, while determining they did not differ on work-family conflict, work-extracurricular conflict and life satisfaction levels. They reported moderate levels of family and extracurricular conflict. Sport managers can utilize this information to better understand the work-life balance of GAs and establish dialogue on ways to improve GAs experience in hopes of keeping these sport professionals in the industry long-term. A COMPARATIVE ANALYSIS OF WORK-LIFE BALANCE IN INTERCOLLEGIATE ATHLETIC GRADUATE ASSISTANTS AND SUPERVISORS by SHAINA ERVIN A Thesis Submitted in Partial Fulfillment of the Requirements for the Degree of Masters of Sport Administration in the Department of Kinesiology and Health in the College of Education Georgia State University Atlanta, GA July, 2012 Copyright by Shaina Ervin 2012
Flow Cytometric Detection of Circulating Tumor Cells in Breast Cancer Patients: A Blinded Study

Circulating tumor cells are cells that detach from the primary tumor site and migrate to the bone marrow or other tissues where they can initiate a metastatic site. Liquid biopsies are an emerging tool in the past decades that enables us to detect Circulating Tumor Cells in patients’ blood. Flow cytometry is a powerful tool used in liquid biopsy diagnostics. This aims to prove the sensitivity and specificity of a flow cytometric panel for the detection of CTCs in breast cancer patients using healthy individuals’ samples as controls. The study was blinded to the data analyzing researcher. Statistical analysis followed and results show 86.9% area under the curve which indicates that the particular method can be very promising for diagnosing breast cancer.
Epigallocatechin-3-gallate suppresses neutrophil migration speed in a transgenic zebrafish model accompanied by reduced inflammatory mediators

Background Polyphenol catechins from green tea, particularly (−)-epigallocatechin-3-gallate (EGCG), exhibits numerous beneficial health effects, although the mechanisms remain unclear. Methods In this study, the mechanism of EGCG-mediated healing in an experimentally injured zebrafish model was examined at the cellular and molecular level using confocal microscopy and gene expression analysis. Results The mechanisms of action of EGCG were shown to involve: (1) reducing neutrophil response (accumulation, travel speed, and distance) and (2) downregulating the expression of IL-1β, TNFα, and related signaling pathways. As determined by dynamic time-lapse tracking studies, the local accumulation of neutrophils with high migration speeds after wounding (n=33 cells, v=0.020 μm/s, d=37.8 μm), underwent significant reduction following treatment with EGCG doses of 300 μM (n=22 cells, v=0.013 μm/s, d=39.5 μm) and 600 μM (n=18 cells, v=0.008 μm/s, d=9.53 μm). Reverse transcription polymerase chain reaction studies revealed that several signature genes in the IL-1β, TNFα, and related signaling pathways were downregulated after EGCG treatment. Conclusion The convenience, transparency, and simplicity of the zebrafish model facilitate tracking of fluorescent neutrophils in real time, in order to monitor inflammation, and assess the impact of therapeutic agents.
A Time-Course Study on Essential Oil of Rosemary (Rosmarinus officinalis) Under Drought Stress

Bu calisma ile birlikte, kuraklik stresi altindaki biberiyenin (Rosmarinus officinalis) ucucu yag profilinde meydana gelen degisimler arastirilmistir. Biberiye yapragi ornekleri uc ardisik gun icerisinde toplanmis ve daha sonra kuraklik stresine maruz birakilan bitkiler iyilestirme amacli sulanmistir. Sonuc olarak GC-MS Headspace sistemi ile yapilan analize gore 26 bilesen belirlenmistir. a-pinen, kamfen, β-pinen, β-myrcene, p-cymene, D-limonen, okaliptol ve kafur, tanimlanan bilesiklerin % 84, 874'unu temsil eden ana bilesenler olarak belirlenmistir. Bu bilesiklerin a-pinen, β-myrcene ve kafur yuzdesi kuraklikla artmis, ancak β-pinen yuzdesi azalmistir. Ayrica, Zayiflatilmis Toplam Yansima Fourier Donusumu Kizilotesi spektroskopisi kullanilarak biberiye yapraklarindaki lipit, amit ve karbonhidrat bolgelerinde meydana gelen degisimler de incelenmistir. Lipitlere, amitlere ve karbonhidratlara karsilik gelen 2920 ila 2852, 1727 ila 1687 ve 1452 ila 1035 cm-1 bant yogunluklarinin sirasiyla CRD1, CRD2, CRD3, CD3, SD3, SRD1'de daha yuksek oldugu belirlenmistir. Tum deney gruplari dikkate alindiginda, kontrol grubunda lipit, amit ve karbonhidrat bant yogunluklarinin kismen daha yuksek oldugu gozlenmistir. Deney gruplarinin ayrimi icin varyans analizi, kumeleme analizi ve temel bilesen analizi yapilmistir. Kuraklik ve sulanan (kontrol grubu) gruplar, ayirt edici istatistiksel araclar kullanilarak dogru bir sekilde ayirt edilmis ve dogrulanmistir. Ayrica degisen cevresel kosullara yanit olarak metabolitlerin olasi rolu ortaya konulmustur.
Pharmacist intervention to enhance postoperative fluid prescribing practice in an Iraqi hospital through implementation of NICE guideline

Objective: The objectives of this study were to evaluate the current practice of postoperative fluid prescribing and assess the effectiveness of pharmacist-led intervention in the implementation of the National Institute of Health and Care Excellence (NICE) fluid therapy guideline in an Iraqi hospital. Methods: The prospective interventional study was conducted at AL-Hilla Teaching Hospital, Babylon, Iraq between November 2017 and July 2018. The study included two phases: The pre-intervention phase with 84 patients and the post-intervention phase with 112 patients. A pharmacist provided training and educational sessions for the hospital physicians and pharmacists about the NICE guideline of fluid therapy. The researcher calculated the amount of given post-operative fluids and compared to the NICE guideline and also measured the patients’ body weight, serum Na, K and creatinine pre-and post-operatively. Results: The pre-intervention phase showed no correlation between the amounts of prescribed fluids and body weight which caused increases in patients’ body weight. In pre-intervention phase, 6% of patients experienced hyponatremia, 19% had hypernatremia and 7.1% had hypokalemia. In the post-intervention phase, abnormal level of electrolytes and patient weight gain decreased significantly. Additionally, the intervention led to a strong correlation between body weight and amount of prescribed fluids in addition to lowering the incidence of electrolyte disturbances. Conclusions: A high proportion of patients in the pre-intervention phase experienced fluid overload, weight gain and electrolyte disturbances when fluid therapy was not prescribed in accordance with the NICE guidelines. The pharmacist-led intervention increased the surgeon awareness of the proper use of the NICE guideline which decreased the incidence of fluid-related complications and the inconsistency of fluid prescribing. Pharmacists can play a critical role to enhance post-operative fluid prescribing and minimize fluid-induced complications.
4D dosimetry and motion management in clinical radiotherapy

Many novel modulated radiation treatment techniques are sensitive to patient motion which may degrade the dose distribution considerably. As there may be a simultaneous movement of the tumour and treatment machine, undesired heterogeneities in the dose distribution can be resulted. Methods to estimate the dosimetric effect of motion and treatment deliveries for both photons and protons are needed. We have recently studied Hodgkin’s lymphoma, liver and left sided breast cancer cases and developed tools to be able to simulate simultaneous organ movement and treatment delivery. Furthermore, it is of great importance to validate potential simulations in a realistic quality control set-up, ideally including a complete dosimetry volume and movement/deformation (4D). Radiation sensitive deformable gels have the potential to meet this dosimetry challenge owing to the unique 3D characteristic to form both phantom and detector in one volume. Multi-array detectors together with a moving platform and a realistic object trajectory is an alternative to evaluate the clinical setting. The evaluation could then in principle be done on-line. Gel/plastic 3D dosimeters have the potential to also be irradiated during motion in a similar matter but have to be read-out post irradiation.
Effect of yoga-based interventions for anxiety symptoms: A meta-analysis of randomized controlled trials.

Anxiety is a common and debilitating condition, which tends to follow a chronic course if left untreated. While studies have provided evidence that yoga is an effective mind-body intervention for a variety of psychological symptoms, more meta-analytic evidence supporting yoga’s efﬁcacy speciﬁcally for anxiety symptoms is needed. The aim of this study was to investigate the effect of yoga on anxiety symptoms using meta-analytic methods. A systematic search was conducted for randomized controlled trials (RCTs) on yoga and anxiety on electronic databases over key terms. Risk of bias was assessed using the Cochrane tool. Outcome data were extracted from eligible studies, and moderators were coded across studies to indicate differences in study sample, delivery method, and type of dependent variable. Effect size aggregation and omnibus analyses, as well as moderator tests, were performed. A total of 38 RCTs ( N (cid:2) 2,295 adults) met inclusion criteria. Yoga practice had a large and statistically significant effect on anxiety symptoms compared with control conditions ( d (cid:2) 0.80). In subomnibus analyses, statistically signiﬁcant effects of the yoga intervention were detected on biological measures ( d (cid:2) 0.45), nonanxiety mental health outcomes ( d (cid:2) 0.55), physical health measures ( d (cid:2) 0.45), and mental and physical health outcomes combined ( d (cid:2) 0.65). Signiﬁcant moderation was found by study location, with the largest effects appearing in Indian samples. Results suggest that yoga signiﬁcantly decreases anxiety symptoms, while it appears to have an ameliorative effect on psychological symptoms more globally.