Miracle-dz/UniFAR-FTUs huggingface dataset:
Diffusion in aqueous gels. Mutual diffusion coefficients measured by one-dimensional nuclear magnetic resonance imaging

A simple, reliable method to measure mutual diffusion coefficients of paramagnetic species in aqueous gel media using one-dimensional nuclear magnetic resonance imaging is reported. The concentration variation with position of a paramagnetic marker yields a corresponding spatial variation in TI relaxation times within the gel. The inversion recovery imaging sequence employed nulls the image intensity from points in the gel with a specified TI value, which permits the position of any chosen marker concentration to be followed as a function of time. The experimental method minimizes the effect of TI relaxation in the gel. A plot of the null position as a function of the square root of time yields, after simple manipulation, the diffusion coefficient. The null point is well resolved with a characteristic signal variation in the vicinity of the null point. Diffusion coefficients of both organic (4-amino-TEMPO) and inorganic (copper sulfate) paramagnetic tracers in 10% polyacrylamide, 1% agarose, and silica gel media are reported.
AWARD NUMBER: W81XWH-05-1-0396 TITLE: Angiogenic Signaling in Living Breast Tumor Models

Multiphoton fluorescence recovery after photobleaching is a well-established microscopy technique used to measure the diffusion of macromolecules in biological systems. We have developed an improved model of the fluorescence recovery that includes the effects of convective flows within a system. We demonstrate the validity of this two-component diffusion-convection model through in vitro experimentation in systems with known diffusion coefficients and known flow speeds, and show that the diffusion-convection model broadens the applicability of the multiphoton fluorescence recovery after photobleaching technique by enabling accurate determination of the diffusion coefficient, even when significant flows are present. Additionally, we find that this model allows for simultaneous measurement of the flow speed in certain regimes. Finally, we demonstrate the effectiveness of the diffusion-convection model in vivo by measuring the diffusion coefficient and flow speed within tumor vessels of 4T1 murine mammary adenocarcinomas implanted in the dorsal skinfold chamber.
Quantum Logic for Precision Spectroscopy

1 Prof. Dr. Piet O. Schmidt, QUEST Institute for Experimental Quantum Metrology, PTB Braunschweig and Leibniz Universität Hannover email: piet.schmidt @ptb.de 2 Dipl. -Phys. Börge Hemmerling, QUEST Institute for Experimental Quantum Metrology, PTB Braunschweig 3 Dipl. -Ing. Birgit Brandstätter, Institute for Experimental Physics, University of Innsbruck 4 Daniel Nigg, QUEST Institute for Experimental Quantum Metrology, PTB Braunschweig and Institute for Experimental Physics, University of Innsbruck
The contributing factors towards e-logistic customer satisfaction: a mediating role of information technology

Article history: Received March 18, 2018 Accepted May 16 2018 Available online May 18 2018 In this era of industrialization, there is an increase rate of e-logistic services, which has raised the necessity to pay more attention on e-logistic customer satisfaction. E-logistic services spread so rapidly worldwide which overlook the significant segment of customer satisfaction. Therefore, the prime objective of the current research study is to develop a comprehensive framework for e-logistics customer satisfaction. Various studies highlighted the area of elogistic customer satisfaction, however, in a rare case, literature formally documented the problem of e-logistic customer satisfaction. Hence, less attention has been paid to the aspect of customer satisfaction in e-logistic. To address this gap, four hypotheses are proposed concerning the relationship of low distribution charges (LDC), low transit time (LTT), effective payment method (EPM), information technology (IT) and e-logistic customer satisfaction. An e-mail survey was preferred, and questionnaires were distributed by using simple random sampling technique. The three hundred (300) questionnaires were distributed among the elogistic users. The results of the current study found that low distribution charges, low transit time, effective payment method and information technology had a positive significant relationship with e-logistic customer satisfaction. Furthermore, information technology found main contributory element between effective payment method and e-logistic customer satisfaction. This study is contributing to the body of knowledge by developing a comprehensive framework to solve various e-logistic problems. Hence, the current study is helpful for e-logistic companies to mitigate e-logistic customer satisfaction problems. ensee Growing Science, Canada by the authors; lic 9 © 201
GEANT 4-Based Model of the CREAM Timing Charge Scintillation Detector

The Cosmic Ray Energetics And Mass (CREAM) instrument is a ba lloon-borne detector designed to measure the cosmic-ray spectrum in the 1-1000TeV e n rgy range, with good charge resolution from protons to iron (Z = 1 to 26). The CREAM instrument has had two successful flights, both from McMurdo Station, Antarctica in the 2004-2005 and 2005-2006 Antarctic summer campaigns, with a combined flight duration of approximately 70 days. The CREAM-I i nstrument consisted of a fast scintillationbased Timing Charge Detector (TCD), a Transition Radiation Detector and a sampling calorimeter. Here we describe a GEANT4-based model for a CREAM TCD scintillati on counter, used in characterizing the charge and timing response of the counters to various inc ide t particles. The model incorporates all counter components, including the scintillator, light gui des and an approximation of the photomultiplier tube (PMT) readout. We compare the simulated output results to actual event signals.
Increasing pregnancies following synchronization of bovine recipients

The success of a commercial embryo transfer program depends on the production of high numbers of viable embryos from donor cows that result in high numbers of calves born when the embryos are transferred to suitable recipients. In recent years, a great deal of effort has been devoted to the development of treatment protocols that permit the efficient use of recipients and result in high pregnancy per recipient synchronized, especially in recipients managed on pasture. One of the most successful alternatives to increase the number of recipients utilized in embryo transfer programs is the use of protocols that allow for embryo transfer without the need for estrus detection, usually called fixed-time embryo transfer (FTET). Pregnancies to FTET have been reported to be similar to those after detection of estrus, but the overall proportion of recipients pregnant over those synchronized are higher because these treatments have increased the proportion of recipients that receive embryos. Treatments that increase progesterone concentrations and pregnancies per embryo transfer have also been investigated in recent years. Most of these treatments have resulted in increased pregnancy per embryo transfer in recipients with Bos indicus influence, while benefit were not so obvious in Bos taurus recipients managed under more optimal conditions. While factors such as the reproductive history of the recipients and the stage and quality of embryos may affect pregnancy per embryo transfer, other factors such as estrus detection and the time interval from thawing to transfer do not seem to affect the proportion of recipients pregnant with embryos frozen in ethylene glycol and transferred at a fixed-time.
Optimal Control of DERs in ADN Under Spatial and Temporal Correlated Uncertainties

The uncertainties of distribution energy resources (DERs) have significant impacts on active distribution networks (ADNs), and it is necessary to control the DER outputs to hedge the negative impacts of their uncertainties on ADNs. However, DER uncertainties are complicated, containing spatial and temporal correlation, which makes it challenging to design proper control schemes, especially when there exist temporal-correlated units such as energy units (EUs). This paper provides an Itô process model to describe the characteristics of stochastic resources and EUs in a unified way, which makes it easy to evaluate the impacts of stochastic resources on temporal-correlated units. Based the moment form of the Itô process model, a moment optimization (MO) approach is provided to transform the stochastic control (SC) problem into an optimization problem with respect to the first-order and second-order moments of the system variables. The scale of MO is comparable to that of the corresponding deterministic control problem, which means that the computational efficiency of MO is much higher than that of traditional approaches. Case studies also show that the proposed approach outperforms existing approaches in both the performance and computational efficiency, which means that the proposed approach has attractive potential for use in large-scale applications.
Telling Women That Men Desire Women With Bodies Larger Than the Thin-Ideal Improves Women’s Body Satisfaction

One source of women’s body dissatisfaction appears to be the media’s suggestion that men desire extremely thin women. Thus, three independent experiments examined whether reversing this suggestion would improve women’s weight satisfaction. In all three studies, women viewed images of female models with bodies larger than the thin-ideal. Women who were randomly assigned to be told that men found those models attractive experienced increased weight satisfaction compared to women who were not given any information (Studies 1 and 2) and women who were told that men preferred ultra-thin women (Study 2). Study 3 (a) provided evidence for the theoretical mechanism—internalization of the thin-ideal—and (b) revealed that telling women that other women find larger models attractive does not yield similar benefits. These findings extend the tripartite influence model by demonstrating that women’s beliefs about men’s body preferences are an important moderator of the association between media influence and women’s body satisfaction.
MAGNETICALLY ACTUATED PARTICLE-BASED PROCEDURES IN CONTINUOUS FLOW

We demonstrate a versatile multilaminar flow microfluidic device in which magnetic particles are used as mobile supports for performing two important applications, namely (i) a clinically relevant sandwich immunoassay, and (ii) polyelectrolyte coating of templates towards the fabrication of microcapsules for drug delivery applications. Furthermore, we demonstrate the use of a different force, diamagnetic repulsion, for deflecting polystyrene particles through a reagent stream with a view to performing multilaminar flow studies on diamagnetic material such as polymer particles and cells.
Radiative heating rates and direct radiative forcing by mineral dust in cloudy atmospheric conditions

We explore several issues relevant to assessments of solar and infrared radiative effects due to mineral aerosols. One issue is the importance of the vertical distribution of dust for calculations of dust radiative heating rates. Another issue is the role that clouds may play in augmenting the radiative forcing by dust. We also explore the importance of the composition of mineral aerosols by employing spectral optical properties for dust that comes from two different regions of the globe, the Saharan and Afghan deserts. A combined longwave and shortwave radiative transfer model was used to determine the instantaneous radiative forcing in the atmosphere, radiative fluxes at the surface, and radiative heating rates by airborne mineral aerosols for clear-sky and cloudy atmospheric conditions. Extensive calculations with our model show that increasing dust loading results in increasing both solar heating rates and infrared cooling rates. However, the net instantaneous rates during the day are always positive, yielding net radiative heating of the dust layer. With similar atmospheric conditions and dust loading, Saharan dust causes larger heating rates than Afghan dust. The magnitudes of the Saharan dust heating rates can easily be 25% larger than Afghan dust heating rates at high Sun angles and over bright surfaces. Also, Saharan dust yields more positive values of TOA (top of the atmosphere) radiative forcing than Afghan dust; and for a diurnal average, this can lead to a change of sign of the TOA radiative forcing from negative to positive just due to mineralogical composition. Clouds significantly influence the direct radiative impact of dust depending on cloud altitude and optical depth. Moreover, this influence is strongly dependent on Sun position and surface albedo.
N budgets and aquatic uptake in the Ipswich River basin, northeastern Massachusetts

We calculated N budgets and conducted nutrient uptake experiments to evaluate the fate of N in the aquatic environment of the Ipswich River basin, northeastern Massachusetts. A mass balance indicates that the basin retains about 50% of gross N inputs, mostly in terrestrial components of the landscape, and the loss and retention of total nitrogen (TN) in the aquatic environment was about 9% of stream loading. Uptake lengths of PO4 and NH4 were measurable in headwater streams, but NO3 uptake was below detection (minimum detection limit = 0.05 μM). Retention or loss of NO3 was observed in a main stem reach bordered by wetland habitat. Nitrate removal in urban headwater tributaries was because of water withdrawals and denitrification during hypoxic events and in ponded wetlands with long water residence times. A mass balance using an entire river network indicates that basin‐wide losses due to aquatic denitrification are considerably lower than estimates from several recent studies and range from 4 to 16% of TDN in stream loading. Withdrawals for domestic use restrict the runoff of headwater catchments from reaching the main stem during low base flow periods, thereby contributing to the spatial and temporal regulation of N export from headwater tributaries.
An Insight Into Software Defined Wireless Networks

The flexibility of future wireless networks architectures is aimed at allowing more innovation, reducing complexity and improving service offerings. Software Defined Networking (SDN) has been identified as an enabler for this adoption. In order to grasp a better understanding of the challenges faced as well as the potential uses cases, we identify the need for flexible software defined wireless network, its applications and challenges and propose an architectural framework.
Meeting the challenges of decentralized embedded applications using multi-agent systems

: Today embedded applications become large scale and strongly constrained. They require a decentralized embedded intelligence generating challenges for embedded systems. A multi-agent approach is well suited to model and design decentralized embedded applications. It is naturally able to take up some of these challenges. But some speciﬁc points have to be introduced, enforced or improved in multi-agent approaches to reach all features and all requirements. In this article, we present a study of speciﬁc activities that can complement multi-agent paradigm in the ”embedded” context. We use our experience with the DIAMOND method to introduce and illustrate these features and activities.
Towards Realization of High Performance Programmable Datapaths using Domain Specific Language

Network virtualization has paved the way for renewed interest in programmable data plane research. Programming Protocol-Independent Packet Processors (P4) being a Domain Specific Language (DSL) brings rich abstractions through a target-independent high-level programming language that can be compiled to run on a variety of targets (e.g., ASIC, FPGA, GPU). We present our Multi-Architecture Compiler System for Abstract Dataplanes (MACSAD) proposal in this article which blends P4 network abstractions with low-level but cross-platform (HW & SW) APIs brought by OpenDataPlane (ODP) and thereon supports different vendors and architectures. We explain the current open questions and trends, and show how MACSAD fits into the landscape. The design decisions behind MACSAD architecture and their impact towards attaining the required characteristics, namely, programmability, performance, portability, and scalability are investigated. Furthermore, We present the results for dynamic CPU core (re)allocation feature and impact of compiler optimization technique exploiting memory-level parallelism in MACSAD.
Solute dynamics during bank storage flows and implications for chemical base flow separation

Chemical base flow separation is a widely applied technique in which contributions of groundwater and surface runoff to streamflow are estimated based on the chemical composition of stream water and the two end‐members. This method relies on the assumption that the groundwater end‐member can be accurately defined and remains constant. We simulate solute transport within the aquifer during and after single and multiple river flow events, to show that (1) water adjacent to the river will have a concentration intermediate between that of the river and that of regional groundwater and (2) the concentration of groundwater discharge will approach that of regional groundwater after a flow event but may take many months or years before it reaches it. In applying chemical base flow separation, if the concentration in the river prior to a flow event is used to represent the pre‐event or groundwater end‐member, then the groundwater contribution to streamflow will be overestimated. Alternatively, if the concentration of regional groundwater a sufficient distance from the river is used, then the pre‐event contribution to streamflow will be underestimated. Changes in concentration of groundwater discharge following changes in river stage predicted by a simple model of stream‐aquifer flows show remarkable similarity to changes in river chemistry measured over a 9 month period in the Cockburn River, southeast Australia. If the regional groundwater value was used as the groundwater end‐member, chemical base flow separation techniques would attribute 8% of streamflow to groundwater, as opposed to 25% if the maximum stream flow value was used.
TITLE: Superoxide dismutase and transcription factor sox9 as mediators of tumor suppression by mac25 (IGFBP-rp1) in prostate cancer cells

The greatest risk factor for developing carcinoma of the prostate is advanced age. Potential molecular and physiologic contributors to the frequency of cancer occurrence in older individuals include the accumulation of somatic mutations through defects in genome maintenance, epigenetic gene silencing, oxidative stress, loss of immune surveillance, telomere dysfunction, chronic inflammation, and alterations in tissue microenvironment. In this context, the process of prostate carcinogenesis can be influenced through interactions between intrinsic cellular alterations and the extrinsic microenvironment and macroenvironment, both of which change substantially as a consequence of aging. In this study, we sought to characterize the molecular alterations that occur during the process of prostate fibroblast senescence to identify factors in the aged tissue microenvironment capable of promoting the proliferation and potentially the neoplastic progression of prostate epithelium. We evaluated three mechanisms leading to cell senescence: oxidative stress, DNA damage, and replicative exhaustion. We identified a consistent program of gene expression that includes a subset of paracrine factors capable of influencing adjacent prostate epithelial growth. Both direct coculture and conditioned medium from senescent prostate fibroblasts stimulated epithelial cell proliferation, 3-fold and 2-fold, respectively. The paracrine-acting proteins fibroblast growth factor 7, hepatocyte growth factor, and amphiregulin (AREG) were elevated in the extracellular environment of senescent prostate fibroblasts. Exogenous AREG alone stimulated prostate epithelial cell growth, and neutralizing antibodies and small interfering RNA targeting AREG attenuated, but did not completely abrogate the growthpromoting effects of senescent fibroblast conditioned medium. These results support the concept that aging-related changes in the prostate microenvironment may contribute to the progression of prostate neoplasia. (Cancer Res 2006; 66(2): 794-802)
Erim Report Series Research in Management the Role of Product Quality Information, Market State Information and Transaction Costs in Electronic Auctions Bibliographic Data and Classifications

Electronic auctions have rapidly increased in popularity, but the consequences of switching to an electronic auction are unclear. In part this is because multiple changes occur at the same time so one can only observe the combined effect of these changes and not the effect of each separate change. For instance, electronic bidders face lower transaction costs, but also have less information about product quality and about the state of the market such as the number of bidders. In this paper, we report a study of bidding behavior at a large Dutch flower auction in which we are able to separate some of these effects. We compare electronic bidders with traditional bidders and when correcting for quality differences and seasonal effects, we find that they to bid lower on average than traditional buyers, as predicted by Bakos (1991, 1997). The electronic bidders were divided in two subgroups, internal bidders and external bidders. The external bidders had less product quality information and market state information than the internal bidders. This led the external bidders to not only bid significantly higher than the internal bidders, but in fact as high as the traditional bidders. Both these effects run counter to theoretical predictions and some possible alternative explanations are offered. In general, it highlights the importance of focusing the information flows that occur in a market.
Diagnostic value of circulating miR-155 , miR-21 , and miR-10 b as promising biomarkers in human breast cancer

Background: Breast cancer (BC) remains one of the top threats to the health of women and so far, there are no powerful and convenient methods to diagnose BC. In this study, we selected 3 microRNAs, miR-155, miR-21, and miR-10b, to assess their diagnostic value in BC screening. Methods: From March, 2014 to March, 2015, 106 BC patients and 106 age-match healthy participants were recruited in our study. Blood samples were collected from the total 206 participants. MicroRNAs were extracted from plasma and quantified by RT-qPCR, which their relative expressions were normalized by external control, cel-miR-39. An new miRNA Score including miR-155, miR-21 and miR-10b, was constructed using multivariate logistic regression. Statistical analyses were conducted to compare microRNAs level as well as other clinical characteristics between two groups. Results: The levels of circulating miR155, miR-21, and miR-10b were significantly up-regulated in BC patients compared with healthy participants. ROC curve analyses revealed that the AUC (95% CI, sensitivity, specificity) value for miR-10b, miR-29c, and miR-205 were 0.692 (95% CI: 0.625-0.754; sensitivity=66.0%, specificity=68.9%), 0.748 (95% CI: 0.684-0.805; sensitivity=77.4%, specificity=67.9%), 0.794 (95% CI: 0.733-0.846; sensitivity=68.9%, specificity=75.3%), respectively. The new miR-score had the best performance with AUC (95% CI, sensitivity, specificity) of 0.860 (95% CI: 0.806-0.903; sensitivity=83.0%, specificity=77.3%). Conclusions: The 3 selected miRNAs, miR-155, miR-21, and miR-10b, were significantly up-regulated in BC patients and may be an ideal, noninvasive screening tool for BC detection.