Miracle-dz/UniFAR-FTUs huggingface dataset:
Perceptual and Neuromuscular Responses Adapt Similarly Between High-Load Resistance Training and Low-Load Resistance Training With Blood Flow Restriction

Abstract Teixeira, EL, Painelli, VdS, Schoenfeld, BJ, Silva-Batista, C, Longo, AR, Aihara, AY, Cardoso, FN, Peres, BdA, and Tricoli, V. Perceptual and neuromuscular responses adapt similarly between high-load resistance training and low-load resistance training with blood flow restriction. J Strength Cond Res 36(9): 2410–2416, 2022—This study compared the effects of 8 weeks of low-load resistance training with blood flow restriction (LL-BFR) and high-load resistance training (HL-RT) on perceptual responses (rating of perceived exertion [RPE] and pain), quadriceps cross-sectional area (QCSA), and muscle strength (1 repetition maximum [RM]). Sixteen physically active men trained twice per week, for 8 weeks. One leg performed LL-BFR (3 sets of 15 repetitions, 20% 1RM), whereas the contralateral leg performed HL-RT (3 sets of 8 repetitions, 70% 1RM). Rating of perceived exertion and pain were evaluated immediately after the first and last training sessions, whereas QCSA and 1RM were assessed at baseline and after training. Rating of perceived exertion was significantly lower (6.8 ± 1.1 vs. 8.1 ± 0.8, p = 0.001) and pain significantly higher (7.1 ± 1.2 vs. 5.8 ± 1.8, p = 0.02) for LL-BFR than that for HL-RT before training. Significant reductions in RPE and pain were shown for both protocols after training (both p < 0.0001), although no between-protocol differences were shown in absolute changes (p = 0.10 and p = 0.48, respectively). Both LL-BFR and HL-RT were similarly effective in increasing QCSA (7.0 ± 3.8% and 6.3 ± 4.1%, respectively; both p < 0.0001) and 1RM (6.9 ± 4.1% and 13.7 ± 5.9%, respectively; both P < 0.0001), although absolute changes for 1RM in HL-RT were greater than LL-BFR (p = 0.001). In conclusion, LL-BFR produces lower RPE values and a higher pain perception than HL-RT. However, consistent application of these approaches result in chronic adaptations so that there are no differences in perceptual responses over the course of time. In addition, muscle strength is optimized with HL-RT despite similar increases in muscle hypertrophy between conditions.
Safety and pharmacokinetics of a biosimilar of denosumab (KN012): Phase 1 and bioequivalence study in healthy Chinese subjects

ABSTRACT Background KN012 is a proposed biosimilar candidate for the reference drug denosumab, with the brand name Prolia®. This study explored the tolerance, variability, and pharmacokinetics (PK) of denosumab and its biosimilar in healthy Chinese subjects. Research design and methods A randomized, double-blind, parallel, two-arm study was performed to analyze the bioequivalence of denosumab biosimilar (60 mg) compared with denosumab. Results The PK properties of denosumab biosimilar were similar to those of denosumab. When denosumab biosimilar was compared to denosumab, the geometric mean ratios (GMRs) of Cmax, AUC0-t, and AUC0-∞ were 98.74%, 102.54%, and 102.18%, respectively, and the 90% confidence interval was observed to be within 80–125%. The inter-subject variability ranged from 31.4% to 34.6%. Five subjects in the denosumab biosimilar group and one subject in the denosumab group were positive for anti-drug antibodies (ADAs) and negative for neutralizing antibodies (NAbs). Adverse reactions were observed in 100% (52 subjects) and 94.0% (47 subjects) of the subjects in the denosumab biosimilar and denosumab groups, respectively. Reductions in the blood calcium and phosphate levels were the most common adverse reactions. Conclusion The PK characteristics were comparable for the denosumab biosimilar and denosumab groups. Their safety profiles were also similar. Trial Registration : The trial is registered at the Chinese Clinical Trial website (http://www.chinadrugtrials.org.cn/index.html #CTR20181231).
Room temperature synthesis of porous SiO2 thin films by plasma enhanced chemical vapor deposition

Silicon dioxide thin films with variable and controlled porosity have been prepared at room temperature by plasma enhanced chemical vapor deposition in an electron cyclotron resonance microwave reactor with a downstream configuration. The procedure consists of the deposition of successive cycles consisting of a sacrificial organic-polymeric layer and, afterward, a silicon dioxide layer. Toluene and oxygen are used as precursors of the organic layers and Si(CH3)3Cl and oxygen for the SiO2. During deposition of the latter, the organic layer is simultaneously burned off. In these conditions, the release of gases produced by oxidation of the organic-polymeric layer take place while the oxide layer is being deposited. Thus, modification of the nucleation and growing mechanism of the silicon oxide thin film take place. The porosity of the final porous SiO2 thin films increases with the thickness of the sacrificial organic layer. The porous SiO2 films prepared with the aforementioned method are free of carbon an.
An Expeditious Method Combining Multi-Components Determination and Fingerprinting Based on Ultra Performance Liquid Chromatography-Photo Diode Array-Tandem Mass Spectrometry and Chemometrics: Application for Authentication and Quality Evaluation of Cornus Officinalis Sieb. et Zucc

Selective and efficient analytical methods for authentication and quality evaluation of herbal medicines are significant and necessary. An expeditious method combining multi-components determination and fingerprinting based on ultra-performance liquid chromatography-photo diode array-tandem mass spectrometry (UPLC-PDA -MS/MS) and chemometrics for authentication and quality evaluation of Cornus Officinalis Sieb. et Zucc was developed. Tandem mass spectrometer operating in multiple reaction monitoring (MRM) was used for determination of three characteristic constituents (morroniside, sweroside, and loganin) in C. Officinalis. Meanwhile, UPLC fingerprint of C. Officinalis was established and the data set was submitted for classification to a suite of chemometrics method. Combing main biologically active components content level and chemometrics analysis, the effects of cultivation area, harvesting, and storage time on the quality of C. Officinalis were investigated. The study reveals that multi-components determination coupled with fingerprinting could be applied for authentication and quality evaluation of C. Officinalis which is accurate, efficient, and reliable.
Fundamentals for the description of hexagonal lattices in general and in coincidence orientation

The connection between the rotation matrix in hexagonal lattice coordinates and an angle-axis quadruple is given. The multiplication law of quadruples is derived. It corresponds to multiplying two matrices and gives the effect of two successive rotations. The relation is given between two quadruples that describe the same relative orientation of two lattices owing to their hexagonal symmetry; a unique standard description of the relative orientation is proposed. The restrictions satisfied by rotations generating coincidence site lattices (CSL's) are derived for any value of the axial ratio ρ = c/a. It is shown that the law for cubic lattices, where the multiplicity Σ of the CSL is equal to the lowest common denominator of the elements of the rotation matrix, does not always hold for hexagonal lattices. A generalization of this law to lattices of arbitrary symmetry is given and another, quicker, method of determining Σ for hexagonal lattices is derived. Finally, convenient algorithms are described for determining bases of the CSL and the DSC lattice.
Synthesis of 2,3‐Dihydro‐4H‐furo[3,2‐c] chromen‐4‐ones and 2,3‐Dihydronaphtho[2,3‐b]furan‐4,9‐diones by the Radical Cyclizations of Hydroxyenones with Electron-Rich Alkenes using Manganese(III) Acetate

Abstract We have obtained dihydrofurans 3a–j in the radical cyclization of 4‐hydroxycoumarin 1a and 2‐hydroxy‐1,4‐naphtoquinone 1b with electron rich alkenes 2a–i by manganese(III) acetate. Methods A and B, which have different molar ratios were studied comparatively in these reactions, and we observed that method B (molar ratio 2:1:3) gave the best results. Treatment of 4‐hydroxycoumarin 1a and electron rich alkenes 2a–e gave 2,3‐dihydro‐4H‐furo[3,2‐c]chromen‐4‐ones 3a–e in 36–86% yields by the method B. Under the same conditions, the reactions of 2‐hydroxy‐1,4‐naphtaquinone 1b with conjugated alkenes 2b and 2f–i afforded 2,3‐dihydronaphtho[2,3‐b]furan‐4,9‐diones 3f–j in an excellent yields.
A rapid, almost quantitative conversion of [11C]carbon dioxide into [11C]carbon monoxide via [11C]formate and [11C]formyl chloride

Abstract [11C]Formic acid can be produced from no-carrier-added [11C]carbon dioxide reliably and instantaneously in almost quantitative radiochemical yield using lithium triethylborohydride in THF. It can react, either on a solid support or as its non-hydrolysed LiEt3B-adduct, with a complex formed from hexachloroacetone and triphenylphosphine in THF at room temperature to give, again almost quantitatively, [11C]formyl chloride. The latter decomposes instantaneously to give [11C]carbon monoxide, providing an interesting alternative for current methods of [11C]carbon monoxide production in radiopharmaceutical chemistry. [11C]Formyl chloride has also potential in low-temperature N-formylation.
Esterified lignin coating as water vapor and oxygen barrier for fiber-based packaging

Abstract Lignin, esterified with palmitic and lauric acid chloride, has been studied for the application as coating on fiber-based packaging material. The aim was to improve the barrier properties against water vapor and oxygen of paperboard. The esterification was followed by Fourier transform infrared spectroscopy, 31P nuclear magnetic resonance spectroscopy, and gel permeation chromatography measurements. The lignin esters were applied on paperboard and formed a continuous film. The moisture barrier property of the coated paperboards was characterized by the water vapor transmission rate (WVTR). A significant decrease in WVTR was observed, for example, 40 g m-2 (for 24 h) for a paperboard coated with 10.4 g m-2 hardwood kraft lignin palmitate. The contact angle of water on the lignin ester coatings was high and stable. For all paperboard samples coated with lignin esters, a significant decrease in oxygen transmission rate was observed. Accordingly, lignin palmitate and laurate have a high potential as a barrier materials in packaging applications.
Diffusion of Radionuclides in Sediments — in situ Studies

The diffusion of " T c , Cs, Eu, 2 3 Np, and 2 4 Am in a sediment from a brackish water bay has been studied, using a combination of laboratory and in situ techniques. Also the distribution coefficients of Sr, I, Cs, Eu, and 2 4 Am between pore water and solid phase vs. depth were determined. Typical distribution coefficients at > 5 cm depth were: S r ^ l 0 m l / g , I < 1 ml/g, Cs<2000ml/g, Eu<5000ml/g and Am ^ 10000 ml/g. The diffusivity of Tc and Np was very low indicating a reduction to the tetravalent state. For the other elements studied a measurable diffusion was observed.
Percutaneous Imaging-Guided versus Open Musculoskeletal Biopsy: Concepts and Controversies

Abstract Bone and soft tissue tumors are a largely heterogeneous group of tumors. Biopsy of musculoskeletal (MSK) tumors is sometimes a challenging procedure. Although the open biopsy is still considered the gold standard for the biopsy of MSK lesions, core needle biopsy can replace it in most cases, with similar accuracy and a low complication rate. The biopsy should be performed in a tertiary sarcoma center where the multidisciplinary team consists of at minimum a tumor surgeon, an MSK pathologist, and an MSK radiologist who can assess all steps of the procedure. Several factors can influence the success of the biopsy including the lesion characteristics, the equipment, and the method used for the procedure. This review highlights some of the important aspects regarding the biopsy of the MSK tumors, with special attention to imaging a guided core needle biopsy and highlighting some of the recent advancements and controversies in the field.
Effects of Transspinal Direct Current Stimulation on Cycling Perception of Effort and Time to Exhaustion.

Ciccone, AB, Fry, AC, Emerson, DM, Gallagher, PM, Herda, TJ, and Weir, JP. Effects of transspinal direct current stimulation on cycling perception of effort and time to exhaustion. J Strength Cond Res XX(X): 000-000, 2020-In the past decade, researchers have investigated the efficacy of transspinal direct current stimulation (tsDCS) on the central nervous system and afferent neuron function in humans. Recently, data have suggested it may be possible for such tsDCS-induced changes in neuromuscular function to enhance performance. This study used noninvasive thoracic spine tsDCS to determine if cycling performance and perception of effort could be modulated by tsDCS. In 3 different stimulation conditions, anodal, cathodal, and sham, subjects cycled at 80% of their maximal aerobic capacity until exhaustion and reported their rating of perceived exertion (RPE) every minute. From this period, we compared the RPE responses over the first 3 minutes and time to exhaustion. There was no significant difference in time to exhaustion between anodal (408 ± 121 seconds), cathodal (413 ± 168 seconds), and sham (440 ± 189 seconds) conditions (p = 0.58). There was no significant difference in RPE from minutes 1-3 (collapsed across time) between anodal (12.9 ± 2.4 arbitrary units (AUs)), cathodal (13.3 ± 2.2 AUs), and sham (12.9 ± 2.1 AUs) conditions (p = 0.51). These data suggest tsDCS condition did not influence cycling performance or perception of effort during high-intensity cycling. Therefore, thoracic spine and lower abdominal montage delivering a current density of 0.071 mA·cm for 20 minutes likely does not substantially improve high-intensity cycling work capacity. Therefore, more research is needed to investigate the efficacy of tsDCS and which stimulation methods may and may not enhance human performance.
Evaluating the Impact of Text De-Identification on Downstream NLP Tasks

Data anonymisation is often required to comply with regulations when transfering information across departments or entities. However, the risk is that this procedure can distort the data and jeopardise the models built on it. Intuitively, the process of training an NLP model on anonymised data may lower the performance of the resulting model when compared to a model trained on non-anonymised data. In this paper, we investigate the impact of de-identification on the performance of nine downstream NLP tasks. We focus on the anonymisation and pseudonymisation of personal names and compare six different anonymisation strategies for two state-of-the-art pre-trained models. Based on these experiments, we formulate recommendations on how the de-identification should be performed to guarantee accurate NLP models. Our results reveal that de-identification does have a negative impact on the performance of NLP models, but this impact is relatively low. We also find that using pseudonymisation techniques involving random names leads to better performance across most tasks.
Phase field model with a variable chemical potential

We study some asymptotic behaviour of phase interfaces with variable chemical potential under the uniform energy bound. The problem is motivated by the Cahn-Hilliard equation, where one has a control of the total energy and chemical potential. We show that the limit interface is an integral varifold with generalized Lp mean curvature. The convergence of interfaces as 0 is in the Hausdorff distance sense.
Operational Definitions for Chronic Liver Disease Manifestations and Recurring Clinical Events in Biliary Atresia.

BACKGROUND The disease course of Biliary Atresia (BA) may be complicated by development of chronic liver disease (CLD) manifestations (e.g. ascites) and recurring clinical events (e.g. cholangitis). Most pediatric CLD-manifestations/events lack standardized operational definitions, leading to inconsistent identification in clinical research. This study aimed to develop operational research definitions of CLD-manifestations/events in BA for application in retrospective analysis. METHODS Operational definitions of CLD-manifestations/events were developed by literature review and revised by a panel of experienced pediatric hepatologists. Definitions were applied to a single-center review of infants with BA post-Kasai. Manifestations/events were captured until last clinical visit with native liver (SNL), liver transplantation (LT), or death. Native liver survival and event-free survival were estimated by Kaplan-Meier method. Cluster analysis was performed to identify similar patterns of manifestation/event development. RESULTS Of 65 infants with BA post-Kasai (2006-18; median Kasai 56.8 days; 65% female), 29 underwent LT (median 12.9 months) and 4 died without LT (median 6.9 months). 76% of CLD-manifestations/events presented within the 1 year. Presence of definite clinically-evident portal hypertension, thrombocytopenia and dCE ascites were associated with poor transplant-free survival (p < 0.01). Similar pattern developments of CLD-manifestations/events identified 3 outcome groups: poor outcomes (87.8% LT/death), SNL with manifestations/events, and SNL with few/no events. CONCLUSION Operational definitions can provide a timely description of the disease course progression in infants with BA. Research definitions may provide better consistency in future pediatric CLD studies. Furthermore, definitions may serve as endpoints in therapeutic trials or used as variables for disease pattern identification in potential multi-center studies.
COVID-19 and human-nature relationships: Vermonters’ activities in nature and associated nonmaterial values during the pandemic

The COVID-19 pandemic has rapidly modified Earth’s social-ecological systems in many ways; here we study its impacts on human-nature interactions. We conducted an online survey focused on peoples’ relationships with the non-human world during the pandemic and received valid responses from 3,204 adult residents of the state of Vermont (U.S.A.). We analyzed reported changes in outdoor activities and the values associated with human-nature relationships across geographic areas and demographic characteristics. We find that participation increased on average for some activities (foraging, gardening, hiking, jogging, photography and other art, relaxing alone, walking, and watching wildlife), and decreased for others (camping, relaxing with others). The values respondents ranked as more important during the pandemic factored into two groups, which we label as “Nurture and Recreation values” and “Inspiration and Nourishment values. ” Using multinomial logistic regression, we found that respondents’ preferences for changes in activity engagement and value factors are statistically associated with some demographic characteristics, including geography, gender, income, and employment status during the pandemic. Our results suggest that nature may play an important role in coping during times of crisis, but that the specific interactions and associated values that people perceive as most important may vary between populations. Our findings emphasize for both emergency and natural resources planning the importance of understanding variation in how and why people interact with and benefit from nature during crises.
TWIN TRANSIENT‐STATE CYLINDRICAL‐PROBE METHOD FOR THE DETERMINATION OF THE THERMAL CONDUCTIVITY OF SOIL

The twin transient-state cylindrical-probe method was investigated to determine the thermal conductivity of soil. The apparatus consists of the same two probes, which are made of stainless steel pipe, into which heating wire and a thermocouple are placed. One probe is introduced into the standard material (1 percent agar solution) and the other into the measuring material. An electric current is passed through the heating wires of both probes for about 40 sec. Changes in the temperature of the probes are recorded with an X-Y recorder. The locus of the X-Y recorder is a straight line, and the tangent of the line is the ratio of the thermal conductivity of the two materials. The thermal conductivity of soil can be measured directly from the tangent with a high accuracy.
Differential expression of antioxidant system genes in honey bee (Apis mellifera L.) caste development mitigates ROS-mediated oxidative damage in queen larvae

Abstract The expression of morphological differences between the castes of social bees is triggered by dietary regimes that differentially activate nutrient-sensing pathways and the endocrine system, resulting in differential gene expression during larval development. In the honey bee, Apis mellifera, mitochondrial activity in the larval fat body has been postulated as a link that integrates nutrient-sensing via hypoxia signaling. To understand regulatory mechanisms in this link, we measured reactive oxygen species (ROS) levels, oxidative damage to proteins, the cellular redox environment, and the expression of genes encoding antioxidant factors in the fat body of queen and worker larvae. Despite higher mean H2O2 levels in queens, there were no differences in ROS-mediated protein carboxylation levels between the two castes. This can be explained by their higher expression of antioxidant genes (MnSOD, CuZnSOD, catalase, and Gst1) and the lower ratio between reduced and oxidized glutathione (GSH/GSSG). In worker larvae, the GSG/GSSH ratio is elevated and antioxidant gene expression is delayed. Hence, the higher ROS production resulting from the higher respiratory metabolism in queen larvae is effectively counterbalanced by the up-regulation of antioxidant genes, avoiding oxidative damage. In contrast, the delay in antioxidant gene expression in worker larvae may explain their endogenous hypoxia response.
Whole Egg Vs. Egg White Ingestion During 12 weeks of Resistance Training in Trained Young Males: A Randomized Controlled Trial.

Bagheri, R, Moghadam, BH, Ashtary-Larky, D, Forbes, SC, Candow, DG, Galpin, AJ, Eskandari, M, Kreider, RB, and Wong, A. Whole egg vs. egg white ingestion during 12 weeks of resistance training in trained young males: a randomized controlled trial. J Strength Cond Res XX(X): 000-000, 2020-The primary purpose was to compare the effects of whole egg ingestion and egg white ingestion during 12 weeks of resistance training (RT) on muscle cross-sectional area, body composition, muscular strength, and anaerobic power in resistance-trained young males. A secondary purpose was to examine systemic hormonal responses. Thirty resistance-trained young males were randomly assigned to one of 2 groups: Whole eggs + RT (WER; n = 15) or egg whites + RT (ERT; n = 15). Whole eggs + RT ingested 3 whole eggs immediately following RT, whereas ERT ingested an isonitrogenous quantity consisting of 6 egg whites immediately following RT. Before and after 12 weeks of whole-body undulating periodized RT (3 sessions per week), knee extensor muscle mass and cross-sectional area (computed tomography), lean body mass and body fat percentage (bioelectrical impedance), muscular strength (knee extension, handgrip strength), Wingate (cycle ergometer), and serum concentrations of hormones were assessed. There was a significant group × time interaction for body fat percentage, serum testosterone, knee extension, and handgrip strength with greater improvements observed in WER. There was a significant main effect of time (p < 0.05) for knee extensor muscle mass, cross-sectional area, lean body mass, anaerobic power, and all other blood hormones. There was a trend (p = 0.06) in the WER group for having a greater change in lean body mass compared with that of ERT. Postexercise whole egg ingestion increases knee extension and handgrip strength, testosterone, and reduces body fat percentage compared with postexercise egg white ingestion, despite no group differences in muscle mass, in resistance-trained young males. Whole eggs consumption may be preferable during RT programs geared toward the improvement of muscular strength and body fat percentage.