Miracle-dz/UniFAR-FTUs huggingface dataset:
SiC-based Support Converter for passive front-end AC drive applications

The paper presents a simulation study of the Support Converter (SC) for passive front-end 55 kVA AC drive, which is aimed to improve the system performance. Most of time, the converter acts as a parallel Active Power Filter (APF) taking advantage from fast SiC devices application. During the regenerative breaking the SC may feed energy back to the supply grid. The complete system, including an advanced control system based on Direct Power Control with Space Vector Modulation concept, is modeled with the use of Saber package. Moreover, an estimation of the power losses is presented on the base of simulation results and switching performance tests of SiC MOSFETs and Schottky diodes. When harmonic compensation mode is considered semiconductor power losses are expected to be on the level of 120W (0.22% of nominal drive power). The converter is also expected to restore major part of energy from regenerative braking (power limit up to 28 kW) of the drive with total efficiency around 97.5%.
Utility of food pellets containing 1-aminobenzotriazole for longer term in vivo inhibition of cytochrome P450 in mice

Abstract 1. The utility of 1-aminobenzotriazole (ABT), incorporated in food, has been investigated as an approach for longer term inhibition of cytochrome P450 (P450) enzymes in mice. 2. In rats, ABT inhibits gastric emptying, to investigate this potential limitation in mice we examined the effect of ABT administration on the oral absorption of NVS-CRF38. Two hour prior oral treatment with 100 mg/kg ABT inhibited the oral absorption of NVS-CRF38, Tmax was 4 hours for ABT-treated mice compared to 0.5 hours in the control group. 3. A marked inhibition of hepatic P450 activity was observed in mice fed with ABT containing food pellets for 1 month. P450 activity, as measured by the oral clearance of antipyrine, was inhibited on day 3 (88% of control), week 2 (83% of control) and week 4 (80% of control). 4. Tmax values for antipyrine were comparable between ABT-treated mice and the control group, alleviating concerns about impaired gastric function. 5. Inclusion of ABT in food provides a minimally invasive and convenient approach to achieve longer term inhibition of P450 activity in mice. This model has the potential to enable pharmacological proof-of-concept studies for research compounds which are extensively metabolised by P450 enzymes.
Production of 5′ Nucleotide by Using Halophilic Nuclease H Preferentially Adsorbed on Flocculated Cells of the Halophile Micrococcus varians subsp. halophilus

A bioreactor with a column of flocculated cells of the moderate halophile Micrococcus varians subsp. halophilus which adsorbed the halophilic nuclease H was designed to be used in the production of 5′ nucleotides from RNA. A remarkable characteristic of the flocculated cells was that they preferentially adsorbed much exogenous nuclease, excluding adsorbed 5′ nucleotidase. Furthermore, desalting treatment of the flocculated cells in the presence of 2% MgSO4 · 7H2O gave rise to selective inactivation of 5′ nucleotidase without the loss of nuclease H activity, and 5′-guanylic acid was produced with the bioreactor.
Characterization of equine E‐selectin

Expression of E‐selectin on activated endothelium is a critical initial step that leads to extravasation of leucocytes during inflammation, yet E‐selectin is largely uncharacterized in several animal species including the horse. We have sequenced and compared E‐selectin genes derived from activated cultures of purified equine (horse), cervid (black‐tailed deer) and ovine (sheep) pulmonary artery endothelial cells (ECs). Phylogenetic and amino acid sequence comparisons indicate that bovine, cervid and ovine E‐selectin are similar, whereas human and equine E‐selectin are more closely related to each other than to the ruminant molecules. Human E‐ and P‐selectin‐specific monoclonal antibodies that also recognize equine E‐selectin were identified and used to characterize its expression. Expression of E‐selectin was more readily induced by lipopolysaccharide treatment in equine ECs than in human ECs and supported adhesion and activation of neutrophils, consistent with the extreme sensitivity of horses to endotoxaemia and septic shock.
All aggressive lymphoma subtypes do not share similar outcome after front-line autotransplantation: a matched-control analysis by the Groupe d'Etude des Lymphomes de l'Adulte (GELA).

BACKGROUND Data are still conflicting on the indication of front-line autologous stem-cell transplantation (ASCT) as consolidation for aggressive lymphoma. To assess the therapeutic effect of ASCT among different aggressive lymphoma subtypes, we conducted a matched-control analysis by pooling the data from two Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials. PATIENTS AND METHODS Between October 1987 and September 1998, 330 patients received ASCT after achieving complete remission with the ACBVP induction regimen. The histological slides showed: B aggressive non-Hodgkin's lymphoma (B-NHL) in 249 patients (75%), T-NHL in 52 patients (15%) (including 23 T anaplastic) and non-classified NHL in 29 patients. The age-adjusted International Prognostic Index (aaIPI) was 2 or 3 in 66%. Patients were matched with controls from the same GELA database but treated with chemotherapy only. RESULTS ASCT did not benefit non-anaplastic T-NHL patients [5-year overall survival (OS) 44% (chemotherapy) versus 49% (ASCT), P=0.87; disease-free survival (DFS) 38% versus 45%, P=0.89] in comparison with B-NHL [5-year OS 77% (chemotherapy) versus 79% (ASCT), P=0.64; DFS 67% versus 72%, P=0.13]. However, for B-NHL patients with aaIPI score 2 or 3, the benefit of ASCT was significant. CONCLUSIONS This cohort study confirms the high efficacy of front-line ASCT in responding aggressive B-NHL patients with adverse prognostic factors.
Using Cultural Differences to Join People with Common Interests or Problems in Enterprise Environment

This paper describes a methodology to identify people with common subjects but different cultures. Each person has a culture and it influences in his way to express himself or to write, etc. Because of that, nowadays, on the Web, it is very difficult a person who writes ’validating enterprise system’ finds another who writes ’attesting B2B solution’ because there are different words. On the other hand, there is a common subject that search engines can not identify, because it is necessary taking into consideration the cultural knowledge and experience from each person. In this context, the methodology presented here intends to consider this cultural information in order to identify when two or more people are talking about the same subject.
Location-Aware QoS based Web Service Recommendation and Ranking

The number of web services with similar functionality increases which makes the service users depend on web service recommendation systems. During these days it was found that the service users pay more attention on the non-functional properties which are also known as Quality Of Service (QoS) in selecting a best Web Service. Collaborative filtering methods are used in predicting the QoS values effectively. Existing methods generally consider a single QoS factor in recommendation. They rarely consider the personalized influence of users and services in determining the similarity between users and services. The proposed system is improved by integrating different QoS aspects in consideration which includes response time, CPU usage, latency.etc. By including more QoS values helps in finding the best web service for the service user and this is done by replacing the Pearson Correlation Coefficient with Cosine Similarity on finding the similarity computation. The proposed system is a ranking based system which integrates user-based and item-based QoS predictions thereby providing a hybrid approach. Many of the nonfunctional properties related to web services depends on user and the service location. The system thus consider the user and the service location to find the similar neighbours for the target user and service and thereby providing a personalized web service recommendation for the service users.
A framework for interval-valued information system

Interval-valued information system is used to transform the conventional dataset into the interval-valued form. To conduct the interval-valued data mining, we conduct two investigations: (1) construct the interval-valued information system, and (2) conduct the interval-valued knowledge discovery. In constructing the interval-valued information system, we first make the paired attributes in the database discovered, and then, make them stored in the neighbour locations in a common database and regard them as ‘one’ new field. In conducting the interval-valued knowledge discovery, we utilise some related priori knowledge and regard the priori knowledge as the control objectives; and design an approximate closed-loop control mining system. On the implemented experimental platform (prototype), we conduct the corresponding experiments and compare the proposed algorithms with several typical algorithms, such as the Apriori algorithm, the FP-growth algorithm and the CLOSE+ algorithm. The experimental results show that the interval-valued information system method is more effective than the conventional algorithms in discovering interval-valued patterns.
Wideband Circularly Polarized Fabry-Perot Antenna [Antenna Applications Corner]

A broadband and high-gain, circularly polarized Fabry-Perot (CPFP) antenna is presented in this article. This antenna employs a two-layer partially reflective surface (PRS) with positive reflective phase gradient, which can improve the 3-dB gain bandwidth of Fabry-Perot (FP) antennas effectively. To generate a circularly polarized (CP) wave, a wideband CP microstrip patch is designed to serve as the feeding source. To validate this concept, an antenna prototype at X band is fabricated. The measurement results show that this antenna achieves a 3-dB gain bandwidth of 28.3% from 8.8 to 11.7 GHz with the peak gain of 14.7 dBi. Within this frequency range, the axial ratio (AR) is below 3 dB and the reflection coefficient is lower than -10 dB.
Herpes simplex Virus Type 1-infected Human Embryonic Lung Cells Studied by Optimized Immunogold Cryosection Electron Microscopy

Herpes simplex virus type 1 (HSV-1) is a common human pathogen of skin and mucous membranes and is potentially dangerous when the infection is disseminated. Viral morphogenesis, especially the mechanism of viral envelopment and the exact pathway for processing and transport of HSV-1 glycoproteins, is still unclear. We report the results of optimized immunogold-labeled cryosection electron microscopy of HSV-1-infected cultured human fibroblasts (MRC-5). The simplified method presented has proved necessary to obtain reproducible results on cellular distribution of viral glycoproteins. It is now possible to demonstrate the viral glycoprotein gD-1, but not gC-1, in the nuclear membranes and to demonstrate gD-1- and gC-1-labeled viral particles in the perinuclear space, and to show the fate of the viral particles in the endoplasmic reticulum and Golgi area in infected cells.
The Importance of 10q Status in an Outcomes-Based Comparison Between 1p/19q Fluorescence In Situ Hybridization and Polymerase Chain Reaction–Based Microsatellite Loss of Heterozygosity Analysis of Oligodendrogliomas

Abstract 1p/19q codeletion is a favorable prognostic marker of oligodendrogliomas. Although fluorescence in situ hybridization (FISH) and microsatellite-based polymerase chain reaction (PCR) for loss of heterozygosity (LOH) are common methods to test for 1p/19q codeletion, it is unclear which test is better at prognostic stratification. This study analyzed outcomes of 111 oligodendrogliomas with both 1p/19q FISH and LOH done at the time of diagnosis. Overall concordance between the 2 assays was 81.1%. In grade III oligodendrogliomas, LOH was better than FISH at survival stratification (p < 0.0001 for LOH vs p = 0.02 for FISH), although increasing the stringency of FISH interpretation criteria improved concordance and prognostic power. Oligodendrogliomas that were 1p/19q-codeleted by FISH but also had 10q LOH were negative for 1p/19q codeletion by PCR analysis in more than 70% of cases, with very poor survival in the grade III subset. Thus, although PCR-based LOH is a better stratifier of 1p/19q status, FISH still has clinical and prognostic utility, especially if 10q data can be incorporated.
USE OF ENZYME-TREATED CELLS IN GROUPING DRIED BLOODSTAINS*

The grouping of dried bloodstains is a difficult, tedious, and time-consuming procedure which requires proper preparations, techniques, and patience, coupled with ability and experience, to evaluate properly results of tests conducted. It has been shown that a bloodstain may undergo serious alterations in its composition between the time of its deposit and the time of examination in the laboratory. It is imperative for the forensic investigator to be acquainted with the difficulties that may be encountered. It follows that the forensic investigator should have at his command as many techniques as possible to cope with the various problems that arise in attempting to group
The emotional and cognitive impact of unexpected simulated patient death: a randomized controlled trial.

BACKGROUND Observational studies suggest that emotions experienced during simulation training may affect cognitive load and learning outcomes. The objective of this study was to manipulate emotions during simulation training and assess the impact on cognitive load and learning. METHODS In this prospective randomized trial, 116 final-year medical students received training in a simulated scenario of a 70-year-old woman presenting with reduced consciousness due to aminosalicylic acid ingestion. Training groups were randomly allocated to one of two endings for the scenario: The patient was transferred to another service, or she experienced a cardiorespiratory arrest and died. Participants rated their emotions and cognitive load after training. Three months later, we evaluated their performance on a simulation Objective Structured Clinical Examination station of a 60-year-old man presenting with reduced consciousness due to ethylene glycol ingestion. RESULTS Emotions tended to be more negative for students in training groups where the simulated patient died. These students also reported a higher cognitive load (mean ± SD, 7.63 ± 0.97 vs 7.25 ± 0.84; P = .03; d = 0.42) and were less likely to be rated as competent to diagnose and manage a patient with reduced consciousness due to toxin ingestion (OR, 0.37; 95% CI, 0.14-0.95; P = 0.04) 3 months later. CONCLUSIONS Students exposed to unexpected simulated patient death reported increased cognitive load and had poorer learning outcomes. Educators need to expose learners to negative experiences; therefore, further studies are needed on how best to use negative emotional experiences during simulation training.
RELATIONSHIP BETWEEN DEPRESSIVE SYMPTOMS AND COGNITIVE STATUS IN ACUTE ISCHEMIC STROKE

Depressive symptoms and cognitive impairment frequently occur already in the acute phase of ischemic stroke. The aim of the study was to determine whether there was an association between depressive symptoms and different domains of the cognitive status in acute ischemic stroke patients and to identify cognitive domains that significantly correlated with the presence of depressive symptoms. The study comprised 40 acute ischemic stroke patients (26 men and 14 women) aged 45-78 years, with 8-16 years of education. The presence of depressive symptoms was assessed using the self-reported Beck’s Depression Inventory (BDI), whereas the cognitive status was evaluated using a comprehensive neuropsychological testing battery measuring performance in different cognitive domains. The following domains were evaluated: executive function, language, immediate recall, delayed recall, attention, divergent reasoning, and visual-constructive performance in two dimensions. The multiple regression analysis was applied. The results showed a significant association between the presence of depressive symptoms and different cognitive domains. The domain of language was found to be a significant partial predictor of depression, with poorer performance in this domain correlating with a higher prevalence of depressive symptoms.
Operational comparison of single-dose azithromycin and topical tetracycline for trachoma.

PURPOSE World Health Organization guidelines for antibiotic treatment of trachoma currently include a 6-week course of tetracycline eye ointment twice daily or a single dose of oral azithromycin. Previous trials have shown similar efficacy of these two alternatives when administration of the ointment was carefully supervised. It is believed, however, that azithromycin may be a more effective treatment in practice, and the purpose of this study was to test that hypothesis. METHODS A masked randomized controlled trial was conducted to compare azithromycin and tetracycline under practical operational conditions-i.e., without supervision of the administration of the ointment. Three hundred fourteen children aged 6 months to 10 years with clinically active trachoma were recruited and individually randomized to receive one of the two treatments. Follow-up visits were conducted at 10 weeks and 6 months. The outcome was resolution of disease (clinical "cure"). RESULTS Children allocated to azithromycin were significantly more likely to have resolved disease than those allocated to tetracycline, both at 10 weeks (68% versus 51%; cure rate ratio, 1.31; 95% confidence interval [CI], 1.08-1.59; P = 0.007) and at 6 months (88% versus 73%; cure rate ratio, 1.19; 95% CI, 1.06-1.34; P = 0.004). Azithromycin was particularly effective for intense inflammation (P = 0.023, Fisher's exact test). CONCLUSIONS Single-dose oral azithromycin was a more effective treatment for active trachoma than tetracycline ointment as applied by caregivers. The high cure rate achieved with tetracycline in this study in the absence of supervision and the significantly higher costs of azithromycin, suggest that in the absence of donation programs, switching routine treatment from tetracycline to azithromycin would not be a good use of resources.
Response Inhibition Can Affect Reaction Time to Abrupt-Onset Visual Displays

Reaction time (RT) to abrupt-onset stimuli has been widely used for more than a century to measure the duration of perceptuo-cognitive and motor processes [Donders, 1868/1969 Attention and Performance II (1969 Acta Psychologica 30 412–431)]. A complicating factor with the RT method is that of response withholding, or response inhibition (RI). The occurrence of RI (under this or other names) has been widely discussed in relation to studies of motor processes but has been largely ignored in relation to studies of perceptuo-cognitive processes. We demonstrate that RI can be a confounding factor when RT to abrupt-onset displays is used to study perceptual and cognitive processes. In experiment 1, new-object targets were more accurately detected than old-object targets in an unspeeded task, but were responded to more slowly in an RT task. Consistent with an interpretation in terms of RI, this pattern of results was dependent on the difficulty of target detection. The data of three further experiments also support predictions from the RI interpretation. It is suggested that RI may be an under-acknowledged factor in RT studies of perceptual and cognitive processes with abrupt-onset displays.
Dapagliflozin: drug profile and its role in individualized treatment

Dapagliflozin is the first sodium-glucose co-transporter inhibitor developed. An extensive program covering all phases of clinical research showed us the efficacy and safety profile of the drug. Dapagliflozin and the other SGLT2 inhibitors are a new treatment alternative in patients with Type 2 diabetes either as monotherapy or combined with the hypoglycemic agents currently available and is approved in approximately 38 countries worldwide. This drug profile provides the necessary tools to assess the risks and benefits of this new molecule.
Estimation of symptom-free days in generalized anxiety disorder

ABSTRACT Objective: The efficacy of treatments for generalized anxiety disorder has usually been measured in terms of response or remission of symptoms. These endpoints, however, may not adequately capture the transient periods of symptom abatement and relapse characteristic of chronic psychiatric disorders. Here, we evaluate the measurement of treatment effectiveness in terms of the number of symptom-free days (SFDs). Research design and methods: A pooled analysis was performed of data from five manufacturer-initiated trials of venlafaxine extended-release (XR) in patients with generalized anxiety disorder without co-morbid major depressive disorder. The trials were randomized, double-blind, placebo-controlled and of 8 weeks duration (total intent-to-treat population 1295 venlafaxine XR, 544 placebo). Two of the studies had extensions up to 6 months (intent-to-treat population 514 venlafaxine XR, 253 placebo). The patients were ≥ 18 years of age with a Hamilton Rating Scale for Anxiety (HAM-A) score of ≥ 18. Main outcome measures: SFDs were estimated using weekly scores on the HAM-A. Values of 7 and 0 SFDs, respectively, were assigned to each week the patient had a HAM-A score of ≤ 7 (the remission threshold) and ≥ 18 (the minimum threshold for anxiety). Fractional SFD values were assigned proportionately to weekly HAM-A scores between 7 and 18. Results: The median (inter-quartile range) SFDs were 19 (2–36) for venlafaxine XR and 10 (0–27) for placebo in the 8‐week studies ( p < 0.0001). In the 6‐month extension studies the SFDs were 102 (27–139) for venlafaxine XR and 36 (0–94) for placebo ( p < 0.0001). Conclusions: SFDs differentiate between active treatment and placebo in clinical trials and may be an appropriate measure of treatment effectiveness.
Mutation survey of known LCA genes and loci in the Saudi Arabian population.

PURPOSE The purpose of this study was to perform a comprehensive survey of all known Leber congenital amaurosis (LCA) genes and loci in a collection of 37 consanguineous LCA families from Saudi Arabia. METHODS Direct PCR and sequencing were used to screen 13 known LCA genes (GUCY2D, CRX, RPE65, TULP1, AIPL1, CRB1, RPGRIP1, LRAT, RDH12, IMPDH1, CEP290, RD3, LCA5). In addition, families without mutations identified were further screened with STR markers around these 13 known LCA genes and two loci. RESULTS Disease-causing mutations were identified in nine of the 37 families: five in TULP1, two in CRB1, one in RPE65, and one in GUCY2D. Mutations in known genes only accounted for 24% of the Saudi families--much less than what has been observed in the European population (65%). Phenotype-genotype analysis was carried out to investigate the LCA disease penetrance for all families whose mutations identified. All identified mutations were found to segregate perfectly with the disease phenotype. On the other hand, severity of the disease varies for different patients carrying the same mutation and even within the same family. Furthermore, based on homozygosity mapping with both STR and SNP markers, one family is likely to map to the LCA3 locus. CONCLUSIONS These results underscore the importance of studying LCA disease families from different ethnic backgrounds to identify additional novel LCA disease genes. Furthermore, perfect segregation between mutation and disease indicates that LCA is fully penetrant. However, phenotypic variations among patients carrying the same mutation suggest that at least some of the variations in the clinical phenotype is due to modification from the genetic background, environment, or other factors.