Miracle-dz/UniFAR-FTUs huggingface dataset:
III. the Physician's Office and Group Practice—Ambulatory Medical Record Systems: F. Practice Review and Quality of Care: CE-TREE: A Computerized Aid for Medical Cost-Effectiveness Analysis

We describe a computerized aid to the study of the cost-effectiveness of medical practices. CE-TREE is a conversational system allowing the user to define and manipulate decision trees for comparing alternative clinical strategies. In contrast to the usual medical application of decision analysis, CE-TREE encourages the simultaneous comparison of strategies using several different outcome measures, which are specified by the user. This mode of comparison makes explicit the trade-offs involved in choosing one strategy over another. CE-TREE provides a number of useful functions for the management and analysis of decision trees. The system is written in Standard MUMPS, and runs on popular minicomputers or microprocessors. It has been used by several physician investigators to study a number of clinical problems and public health issues.
Understandings and perceptions of spirituality held by multidisciplinary professionals involved in a community-based palliative care organization: Implications for professional practice.

As a universal human experience, spirituality is innate to humanity. Nevertheless, the attempt to define spirituality within health care has led to a range of diverse and often nebulous definitions. Holistic practice within palliative care includes the physical, psychological, social, and spiritual aspects of human beings, all of which can facilitate pain for the terminally ill. Commonly, spiritual pain is inadequately addressed within palliative care. This is due to spirituality not being identified or performed by multidisciplinary professionals, who feel untrained and inadequate for the task due to a lack of education or professional development in the area of spirituality. As a part of holistic practice these professionals are called to provide basic spiritual care and make timely spiritual referrals within their everyday practice. A lexicon of spirituality was required to bring appropriate language for the identification and provision of basic spiritual care and judicious referrals to spiritual professionals. As more terminally ill people indicate a desire to die at home, true holistic palliative care that is community-based is becoming crucial. For this research study a small community-based palliative care organization, Ballarat Hospice Care Incorporated, was chosen to be the case study. Understandings and perceptions of spirituality and spiritual care were developed and articulated through extended focus groups and semi-structured individual interviews with members of the multidisciplinary team. The employment of a hermeneutic phenomenological theoretical perspective allowed the essence of the experience of spirituality at BHCI to emerge and be given language by those who worked there. van Manen‘s four fundamental lifeworld existentials of lived space, lived time, lived other, and lived body were used as guides to reflection and interpretation of the textual conversations. Consequently, the definitional framework applied in this research study was of spirituality as connectedness with Self, with Other, with the world, and with mystery/transcendence, not static, but constantly evolving towards ultimate unity. Correspondingly, it also was useful to apply the concept of disconnectedness which identified experiences of possible spiritual pain and despair. This spirituality schema brings common language to what had previously been seen as an ill-defined concept. The connectedness and disconnectedness framework is accessible and can be practically employed to assist the multidisciplinary team in defining and identifying spirituality and spiritual care. Importantly, it is inclusive of all people regardless of belief, values, and personal meanings.
The Impact of Naturopathic Activities on Constipation and Health Promotion of High School Girls in Korea

Objective : This study aims to investigate the factor inﬂuencing on constipation and health, and the effect of 7 - day naturopathic activities on constipation and health. Methods : This uncontrolled intervention study evaluated the risk factors on constipation and health by multiple linear regression with ﬁve indices from 138 high school girls in Korea by a self - re porting survey conducted on November 2 nd , 2008. Moreover after 7 - day naturopathic activities for a week, it analyzed their effect on constipation and health by analysis of covariance (ANCOVA) and multiple linear regression on November 8 th , 2008. Results : Lifestyle and stress signiﬁcantly inﬂuenced constipation and health. The risk factors on constipation were daily water intake (p ＝ 0.010), favorite foods (p ＝ 0.011), exercise per day (p ＝ 0.008) and school stress (p ＝ 0.011). The risk factors on health were the frequency of snack per week (p ＝ 0.005), the volume of daily water intake (p ＝ 0.017), exercise per day (p ＝ 0.021), school stress (p ＝ 0.001) and home stress (p ＝ 0.001). 7 - day naturopathic activities made signiﬁcant decrease in constipation assessment scale (p ＝ 0.012), of which main effector was the volume of daily water intake (p ＝ 0.034). These activities made signiﬁcant increase in health index (p ＝ 0.016), of which main effector was not in lifestyle index but might be in stress index. Meanwhile, they did not make signiﬁcant ﬂuctuation in defecation frequency per week and constipation self - awareness. Conclusion : These results propose that constipation and health were signiﬁcantly inﬂuenced by lifestyle and stress, and that 7 - day naturopathic activities directly had signiﬁcant effect on constipation and might indirectly have effect on health through connecting with stress reduction. These ﬁndings suggest the applicability of naturopathy for constipation care and health promotion.
Early progressive mobilisation following acute subarachnoid or subdural haemorrhage: An observational pilot study

Background/Aims: There is little research regarding early mobilisation following non-traumatic acute subarachnoid (SAH) or subdural haemorrhage (SDH). The aim of this prospective observational study was to document the feasibility and safety of our usual practice regarding the early progressive mobilisation of patients following acute SAH or SDH. Method: Mobilisation was defined as sitting on the edge of the bed or greater. All participants were screened regarding their suitability for mobilisation to commence/continue. Results: Fifty participants were included: 42 mobilised at least once as part of their physiotherapy intervention. The 50 participants received a total of 373 physiotherapy sessions, with mobilisation occurring during 50% of sessions. Neurological reasons most frequently prevented mobilisation. All 42 participants who mobilised at least once achieved the mobility milestone of sitting on the edge of the bed and 86% progressed to walking, usually by 4–5 days post-admission. Poor neurological.
3D Scale for Awareness, Attitude, Stigma of Addiction

Abstract This study’s aim is to develop a three-dimensional scale for awareness, attitude, stigma of substance addiction and addicts. The awareness dimension is composed of knowledge, comprehension, application, analysis, synthesis and evaluation sub-dimensions. Validity and reliability of the study were conducted to understand that the scale items of intended to measure and also validity and meaningfulness of collected data by applying the scale to 317 people. The three-dimensional scale for awareness, attitude and stigma of addiction is valid and reliable. The scale is provided to get simultaneous results on three interrelated dimensions such as awareness, attitude and stigmatization, and is facilitated to deal with the subject with a more holistic approach.
The genetics of adaptation and reproductive isolation in the Drosophila melanogaster species complex.

The genetic bases of adaptation and spéciation, and the interactions between adaptation and spéciation in natural systems are still poorly understood. Here, we investigated the genetic bases of intraand interspecific adaptation in the Drosophila melanogaster species complex. The species pair D. simulans/D. sechellia was used as a model to study the genetic interactions between loci responsible for Z). sechellia's adaptation to a toxic resource and loci involved in reproductive isolation between the two species. We developed microsatellite markers for interspecific mapping of D. simulans and D. sechellia. In the course of characterising the molecular markers, we investigated the sequence structure of microsatellite alleles in order to gain insights about the mechanisms of microsatellite mutation and evolution. We used our microsatellite markers to evaluate the effect of strong local selection on genetic differentiation in populations ofD. simulans and D. melanogaster. We investigated the possibility of indirectly studying the adaptation of D. sechellia to a toxic resource by the development of an experimental protocol to select D. simulans populations for resistance to octanoic acid. The response to selection was weak compared to the interspecific differences observed, possibly because mutations of large effect only occurred in the lineage leading to D. sechellia. The mapping of hybrid sterility factors in the D. simulans/D. sechellia species pair supports the dominance and faster male evolution theories. Male sterility factors were mapped at similar locations to reported factors responsible for D. sechellia's resistance to octanoic acid. The implications of this linkage for the understanding of spéciation process in the D. simulans/D. sechellia system are discussed.
American Heart Journal

HE electrocardiographic patterns of left ventricular hypertrophy or left T ventricular strain in standard limb lead records have received considerable attention from Less detailed attention has been paid to the pattern of left ventricular hypertrophy when using the unipolar limb and precordial leads. The typical pattern obtained by unipolar techniques has been described previously, 11-16 but the atypical ones and those showing lesser degrees of abnormalities have not been detailed adequately. The practical importance of the electrocardiographic position of the heart and of the time of onset of the intrinsic deflection of the ventricular complexes as an aid in diagnosis has been emphasized already.11J6 The purpose of the present investigation is to evaluate the criteria, using unipolar limb and precordipl leads, for the recognition of the atypical and early patterns of left ventricular hypertrophy; to determine the frequency of the characteristic changes noted by Wilson and his associatesll; and to study the diagnostic value of the electrocardiographic position of the heart and of the time of onset of the intrinsic deflection (ventricular activation time).
Perceived control decisions in preparation for a summative achievement test in higher education

Most courses in higher education finish with one or more assessments which commonly all have to be passed. In these courses, student learning is commonly measured using conventional classroom tests, therefore test preparation is a common task for students. In higher education, compared with students’ prior education, they are faced with a more complex curriculum and have to perform their studies with less guidance and limited resources. Therefore, effective and efficient test preparation is important. A strategy to help students study effectively in the context of test preparation is to make the appropriate control decisions, for instance to cease test preparation on specific content and (re) study other subjects that need attention. These control decisions are an important psychological aspect of the test preparation study process. We conducted a qualitative study on how students made control decisions in a test preparation period for a knowledge test in Educational Sciences. The study was conducted with students of a teacher training program at a University of Applied Sciences in the Netherlands. Results show that different progressions of learning judgments and the self-efficacy of students led to two different saturations. This in turn led to students making either no, inaccurate, or accurate control decisions. This article discusses the impact and practical implications of these insights.
A simple and efficient strategy to produce transgene-free gene edited plants in one generation using paraquat resistant 1 as a selection marker

Introduction DNA integration is a key factor limiting the marketing of CRISPR/Cas9-mediated gene edited crops. Several strategies have been established to obtain transgene-free gene edited plants; however, these strategies are usually time-consuming, technically difficult, providing low mutagenesis efficiency, and/or including a narrow host range. Method To overcome such issues, we established a paraquat resistant 1 (PAR1)-based positive screening (PARS) strategy, which achieved efficient screening of transgene-free gene edited plants. With PARS, the screening efficiency of mutant increased by 2.81-fold on average, and approximately 10% of T1 plants selected via PARS were transgene-free. Results Moreover, heritable transgene-free mutations at target loci were identified in the T1 generation. Based on the previous reports and our data, we know that paraquat is toxic to all green plants, PAR1 is conserved among all plant species tested, and the transient expression of Cas9 editor can produce transgene-free gene edited plants. Discussion Thus, we assume that the PARS strategy established here has the potential to be widely used to screen transgene-free mutants in various crops using diverse CRISPR/Cas9 delivery approaches.
Relationship between structural and social dimensions of school culture

The culture of an educational institution is defined as a set of common beliefs and values that closely connect the members of a community. Structural dimensions (space, time, teaching materials, and teaching strategies), social dimensions (relationships among school staff, between teachers and children, and among children), common rituals, and customs and traditions of the school are manifestations of school culture in which it is recognized and becomes visible. The aim of this research is to determine the connection between structural dimensions and social relations in the institution. The research was conducted in 2022 on a sample of 174 primary teachers employed in various schools in the Republic of Croatia. The Questionnaire for the Assessment of the Culture of the Educational Institution was used for data collection. An exploratory factor analysis on the Scale of the State of School Culture, which measured the state of structural dimensions, extracted two factors, based on which two subscales of good metric characteristics were created: organization of educational work and spatial and temporal dimensions. The Scale of the State of Relations in the Institution consists of 13 items and has high reliability. In order to determine the existence of a connection between the structural and social dimensions of school culture, Pearson's correlation coefficients were calculated. Moderate to relatively high positive correlations between the examined variables were found, which confirms the intertwining and interdependence of different dimensions of school culture, which significantly determines the quality of life and education of children in the institutional context.
Anti-inflammatory activities of Coleus forsteri (formerly Plectranthus forsteri) extracts on human macrophages and chemical characterization

Introduction: Formerly named Plectranthus forsteri, Coleus forsteri (Benth.) A.J.Paton, 2019 is a Lamiaceae traditionally used to treat flu-like symptoms and shock-related ecchymosis, especially in the Pacific region. Few studies investigated chemical composition and anti-inflammatory potential of this plant. Method: Herein, we investigated anti-inflammatory potential of C. forsteri ethanolic (ePE) and cyclohexane (cPE) plant extract on LPS-induced human macrophages models and quantified cytokines and quinolinic acid (QUIN) as inflammatory markers. Results: Our results show that extract of ePE and cPE significantly inhibit inflammatory cytokine IL-6 and TNF-α induced by LPS on PMA-derived THP-1 macrophages. QUIN production is also diminished under ePE and cPE treatment in activated human monocyte-derived macrophages (MDMs). Seven abietane diterpenes were characterized from C. forsteri cPE including coleon U (1), coleon U-quinone (2), 8α,9α-epoxycoleon U-quinone (3), horminone or 7α-hydroxyroyleanone (4), 6β,7α-dihydroxyroyleanone (5), 7α-acetoxy-6β-hydroxyroyleanone (6) and 7α-formyloxy-6β-hydroxyroyleanone (7). Discussion: We discussed potential contributions of these molecules from C. forsteri extracts for their anti-inflammatory activities.
Prediction of sediment wear of francis turbine with high head and high sediment content

Wear of runner blades is a common problem affecting the operational reliability of turbines with high head and high sediment content. In order to accurately predict the wear of the turbine runner blade, based on the solid-liquid two-phase flow equation and turbulence model, the full channel numerical simulation of the internal water and sediment flow was carried out, and the sediment volume distribution and sand water velocity on the turbine runner blade were obtained. Then, according to the digital simulation results and the operating parameters of the turbine runner, the sediment wear test scheme for the turbine blade material specimen is designed, and the sediment wear test is carried out on the runner material. According to the test results, the sediment wear curve of runner blade material is obtained and applied to numerical simulation, and the main position and wear degree of turbine blade sediment erosion are predicted. The inspection results of the runner blade wear after the unit has operated for a flood season show that obvious wear can be seen at the outlet edge of the lower band of the runner blade, and the wear position and wear amount are basically consistent with the simulation values. The study is of great importance for predicting the wear of turbine runner blades with high drop height and high sediment content, and for turbine maintenance under complex conditions.
What is the best way to identify patients with white-coat hypertension?

Ambulatory BP monitoring better than home monitoring for ruling out white-coat hypertension Landmark placebo-controlled outcome-based trials demonstrating reduced morbidity and mortality with hypertension treatment did not differentiate essential from white-coat hypertension. Patients were included based on elevated office-based blood pressure measurements. Since we now know that the prevalence of white-coat hypertension is high, it should be ruled out before implementing antihypertensive therapy. Ambulatory blood pressure monitoring is more accurate than home monitoring for ruling out white-coat hypertension. However, ease, simplicity, and availability makes home monitoring a more realistic option for routine clinical practice. When home blood pressure monitoring is used, reliable measurement devices (eg, newer automatic or manual home devices) should be used and patients should be instructed regarding proper use and documentation of blood pressure values to facilitate an appropriate clinical assessment.
Exploring user-generated content related to vegetarian customers in restaurants: An analysis of online reviews

This study aimed to explore and evaluate factors that impact the dining experience of vegetarian consumers within a range of vegetarian-friendly restaurants. To explore the factors and understand consumer experience, this study analyzed a vast number of user-generated contents of vegetarian consumers, which have become vital sources of consumer experience information. This study utilized machine-learning techniques and traditional methods to examine 54,299 TripAdvisor reviews of approximately 1,008 vegetarian-friendly restaurants in London. The study identified 21 topics that represent a holistic opinion influencing the dining experience of vegetarian customers. The results suggested that “value” is the most popular topic and had the highest topic percentage. The results of regression analyses revealed that five topics had a significant impact on restaurant ratings, while 12 topics had negative impacts. Restaurant managers who pay close attention to vegetarian aspects may utilize the findings of this study to satisfy vegetarian consumer requirements better and enhance service operations.
Applicability of vancomycin, meropenem, and linezolid in capillary microsamples vs. dried blood spots: A pilot study for microsampling in critically ill children

Introduction Therapeutic drug monitoring (TDM) has been shown to be clinically beneficial for critically ill patients. However, this is a burden for neonates or children with small circulating blood volumes. Here, we aimed to develop and validate a microsampling TDM platform (including dried blood spots (DBS) and capillary microsamples (CMS)) for the simultaneous quantification of vancomycin, meropenem, and linezolid. Methods Paired DBS and CMS samples were obtained from an intensive care unit (ICU) to evaluate its clinical application. Estimated plasma concentrations (EPC) were calculated from DBS concentrations. Agreement between methods was evaluated using Deming regression and Bland-Altman difference plots. Results The microsampling methods validation showed excellent reliability and compatibility with the analysis of the sample matrix and hematocrit range of the studied population. The DBS and CMS accuracy and precision results were within accepted ranges and samples were stable at room temperature for at least 2 days and 8 h, respectively. Hematocrit had no impact on CMS, but sightly impacted DBS measurements. The CMS and DBS antibiotic concentrations correlated well (r > 0.98). The drug concentration ratio in DBS samples to that in CMS was 1.39 for vancomycin, 1.34 for meropenem, and 0.94 for linezolid. The EPC calculated from the DBS using individual hematocrit ranges presented comparable absolute values for vancomycin (slope: 1.06) and meropenem (slope: 1.04), with a mean of 98% and 99% of the measured CMS concentrations, respectively. Discussion This study provides a microsampling TDM platform validated for clinical use for a rapid quantification of three antibiotics and is suitable for real-time TDM-guided personalization of antimicrobial treatment in critically ill children.
Identifying Chinese social media users' need for affect from their online behaviors

The need for affect (NFA), which refers to the motivation to approach or avoid emotion-inducing situations, is a valuable indicator of mental health monitoring and intervention, as well as many other applications. Traditionally, NFA has been measured using self-reports, which is not applicable in today's online scenarios due to its shortcomings in fast, large-scale assessments. This study proposed an automatic and non-invasive method for recognizing NFA based on social media behavioral data. The NFA questionnaire scores of 934 participants and their social media data were acquired. Then we run machine learning algorithms to train predictive models, which can be used to automatically identify NFA degrees of online users. The results showed that Extreme Gradient Boosting (XGB) performed best among several algorithms. The Pearson correlation coefficients between predicted scores and NFA questionnaire scores achieved 0.25 (NFA avoidance), 0.31 (NFA approach) and 0.34 (NFA total), and the split-half reliabilities were 0.66–0.70. Our research demonstrated that adolescents' NFA can be identified based on their social media behaviors, and opened a novel way of non-intrusively perceiving users' NFA which can be used for mental health monitoring and other situations that require large-scale NFA measurements.