Miracle-dz/UniFAR-FTUs huggingface dataset:
Information specialist collaboration in Europe: collaborative methods, processes, and infrastructure through EUnetHTA

The history of European health technology assessment (HTA) goes back more than 30 years. Almost as old as HTA agencies themselves is the desire to achieve European collaboration. This gained further impetus with the establishment of the European Network of Health Technology Assessment (EUnetHTA) in 2006. In this context, the field of information management faced specific challenges. Although these services are an integral part of HTA and information specialists play a key role here, this field is often not adequately represented in the HTA agencies within EUnetHTA. Furthermore, the organization of HTA production, including the types of HTAs produced, as well as funding, varies considerably. In order to meet these different conditions, information specialists have created various products and defined processes. With the EUnetHTA guideline, a common methodological understanding for the production of rapid Relative Effectiveness Assessments now exists. Furthermore, the Standard Operating Procedures map the complex information retrieval processes within EUnetHTA in a hands-on manner. The newly established Information Specialist Network (ISN) will in future ensure that information specialists are involved in all EUnetHTA assessments and that the methods are applied consistently in all assessments. In addition, the steering committee of the ISN manages enquiries and can be contacted to discuss methodological issues. Major barriers such as heterogeneity in the daily work of the EUnetHTA members can only be overcome through more collaboration and training.
Glossary for randomized clinical trials.

Randomized clinical trials are positioned at the highest level of primary clinical evidence, as they are designed to be unbiased with a reduced risk of systematic error. The Consolidated Standards of Reporting Trials (CONSORT) statement was first developed in 1996 to improve the reporting quality of randomized clinical trials with updates being published subsequently. Recently, the Preferred Reporting Items for RAndomized Trials in Endodontics (PRIRATE) 2020 guidelines were developed exclusively for the field of Endodontics to address the sub-optimal quality of randomized clinical trials submitted to Endodontic journals, which result in many being rejected. A principal flaw in submissions is the fact that many authors are unclear on the keys terms that should be used when developing manuscripts for publication. Clearly, authors should be aware of the most common terms used when conducting and reporting randomized clinical trials. Hence, the aim of the current paper is to present a comprehensive glossary of the terminology used in randomized clinical trials in order to assist authors when designing, executing and writing-up randomized clinical trials.
Rush hours in flower visitors over a day–night cycle

Most research on pollination has focussed on a subset of insect taxa within a narrow time window during daylight hours. As a consequence, we have a limited understanding of the diversity and activity of flower visitors during the night or belonging to taxa other than bees or syrphid flies. Here, we quantified the abundance and species richness of flower visitors in ruderal meadows over repeated 24‐h cycles (i.e. day and night), and identified abiotic factors influencing these patterns. From the plant perspective, we investigated the likelihood of being visited by an insect across a 24‐h cycle. Activity of flower‐visiting insects never dropped to zero over 24‐h. During the day, non‐syrphid Diptera and Hymenoptera were the most abundant, and species‐rich groups of flower visitors, Lepidoptera and Coleoptera during night. While two of the seven most frequently visited plant species were most likely to be visited during the day, five also had a high likelihood to be visited during the night. The abundance and species richness of flower visitors was positively related to temperature during both the day and the night, whereas there was only a positive relationship with brightness during the day. We conclude that non‐syrphid Diptera and nocturnal flower visitors are currently underappreciated. As the latter seem to respond differently to abiotic factors compared to diurnal species, they may potentially increase response diversity and resilience of plant‐pollinator communities. There is an urgent need to improve our understanding of their ecological role and potential decline due to global change.
The Design, Content and Delivery of Relationship and Sexuality Education Programmes for People with Intellectual Disabilities: A Systematic Review of the International Evidence

There is growing empirical evidence regarding the relationship and sexuality experiences and needs of children, young people and adults with intellectual disabilities. A total of twelve papers met the inclusion criteria regarding relationship and sexuality education (RSE) programmes specific to the needs of this population. The preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines were followed and quality appraisal undertaken. The four themes identified were principles informing RSE programme development, design and content of RSE programmes, delivery of RSE programmes and evaluation of RSE programmes. The discussion presents areas that need to be addressed to ensure that people with intellectual disabilities, their families, carers and professionals are fully involved in the design and delivery of RSE programmes. Further research is required to identify the impact of the programmes and the sustained outcomes achieved. Recommendations are made regarding the activities required to enable the development of evidence-based and person-centred approaches to relationship and sexuality programmes.
Effect of diuretics on plasma renin activity in primary hypertension: A systematic review and meta‐analysis

Plasma renin activity (PRA) is regarded as a marker of sodium and fluid homeostasis in patients with primary hypertension. Whether effects of diuretics on PRA differ according to class of diuretic, whether diuretics lead to a sustained increase in PRA, and whether changes in PRA relate to those in blood pressure (BP) is unknown. We performed a systematic review and meta‐analysis of trials investigating the antihypertensive effects of diuretic therapy in which PRA and/or other biomarkers of fluid homeostasis were measured before and after treatment.
Cardiovascular disease risk factors among older people: Data from the National Health and Morbidity Survey 2015

Study on cardiovascular disease (CVD) risk factors and their prevalence among the older people in Malaysia is limited. We aimed to determine the prevalence and factors associated with CVD risk factors using the non-laboratory Framingham Generalized 10-Year CVD risk score among older people in Malaysia. This was a population-based cross-sectional study using data of 3,375 participants aged ≥60 years from the National Health and Morbidity Survey 2015. Sociodemographic, health factors and clinical assessments (anthropometry and blood pressure) were included. Complex survey analysis was used to obtain prevalence with 95% confidence intervals (CI). We applied ordinal regression to determine the factors associated with CVD risk. The prevalence for the high 10-year CVD risk was 72.1%. Body mass index was higher among those aged 60–69 years in men (25.4kg/m2, 95%CI 25.1–25.8) and women (26.7kg/m2, 95%CI 26.3–27.1) than the other age groups. The factors associated with moderate and high 10-year CVD risk were Malay ethnicity (Odds Ratio(OR) 0.76, 95%CI 0.63–0.92, p = 0.004), unmarried status (OR 1.55, 95%CI 1.22–1.97, p<0.001) and physically inactive (OR 0.72, 95%CI 0.55–0.95, p = 0.020). There is a need for future study to evaluate preventive strategies to improve the health of older people in order to promote healthy ageing.
Positive syphilis serology contributes to intracranial stenosis in ischemic stroke patients

The risk of ischemic stroke is increased among people living with syphilis infection; however, whether syphilis is an independently risk for stenosis is unclear. We investigated the clinical, laboratory, and vascular stenosis features of ischemic stroke patients living with positive syphilis serology to evaluate the role of syphilis in cerebral artery stenosis.
Moringa Oleifera Leaf Supplementation on Vitamin a Status of Children in Ada-East District of Ghana

Background Globally over 195 million pre-school children are vitamin A deficient, whilst in Ghana, it was estimated that 72 % of pre-school children are vitamin A deficient. Periodic administration of high dose vitamin A capsules is currently used as a prevention strategy, but this requires appropriate healthcare infrastructure and is donor dependent, hence may not be sustainable if donor support is withdrawn. Inadequate dietary intake of vitamin A-rich foods is a major etiological factor in vitamin A deficiency, so one other prevention strategy could be to promote the consumption of these foods. Plant-based foods such as orange-fleshed roots and tubers, fruits and dark green leafy vegetables like Moringa oleifera (M. oleifera) leaves are rich sources of pro-vitamin A carotenoids that could be beneficial to vulnerable populations in low socio-economic households who mostly derive their nutrition from plant sources. M. oleifera leaves have been reported to improve retinol levels in rats. However, there are only anecdotal reports on the ability of M. oleifera leaves to improve retinol levels in humans. There is the need therefore to conduct evidence-based research to assess the effect of M. oleifera leaves on retinol levels in humans. Objective The objective of the study was to assess the efficacy of M. oleifera leaf supplementation to improve the vitamin A status of children in Ada-East district of Ghana. Methods The interventional study was preceded by an assessment of dietary uses of M. oleifera leaves in Ada-East district through a community survey of mothers/caregivers aged 19 years and above, and an acceptability test of M. oleifera leaf-fortified dishes by children in Ada-East district. Thereafter, iii University of Ghana http://ugspace.ug. edu.gh
Disturbance and diversity in a continental archipelago: a mechanistic framework linking area, height, and exposure

Species–area relationships (SARs) are among the most general patterns in nature. Yet, significant variation in species richness often remains after accounting for area, especially for small islands. One factor thought to influence species richness on small islands is disturbance from the combined influence of tides and waves. Here, we derive a quantitative framework for determining how ocean disturbance impacts island communities, which we then test in plant communities in a temperate island archipelago. We do so by applying some well-developed techniques honed in the marine intertidal zone but rarely applied to studies on land. By estimating and adjusting for the effect of wave exposure on habitable island area, we dramatically improved the fit of the SAR for small islands, nearly doubling the amount of variation in species richness explained (from 37% to 69%). Our predictions of island occupancy also improved using this method. Our approach predicts that small islands (<100,000 m2) are the most affected by ocean-borne disturbance. Given that many archipelagos are susceptible to wave disturbance, future studies should consider how ocean-borne disturbances arising from the matrix might interact with sampling area to influence patterns of species richness on small islands.
Data versus Dogma: New Challenges for SNARE-based Models of “Fast” Exocytosis at Nerve Terminals

Over the last several years, progress in understanding the molecular mechanism of fast, Ca2+-dependent exocytosis at nerve terminals has led to the following textbook picture:The depolarization-dependent opening of presynaptic Ca2+ channels leads to a transient elevation of cytosolic Ca ion activity within the vicinity of docked synaptic vesicles. The binding of Ca2+ to synaptotagmin 1 (or, 2) then initiates a poorly understood reaction that allows vesicular and target SNAREs (soluble,N-ethylmaleimide-sensitivefactorattachment protein receptors) to complete their intermolecular coiling. The energy released by SNARE coiling then drives fusion between the membrane of suitably primed vesicles and the plasma membrane. Although there is widespread agreement that SNAREs and synaptotagmin are crucial for the molecular events that culminate in fast, synchronous exocytosis at neuronal synapses, there remains no consensus about how these proteins trigger the membrane fusion event that is central to this process. This review extends earlier criticisms of models implicating SNAREs in the terminal steps of the exocytotic cascade and explains how recent data are more compatible with a direct role for synaptotagmin 1 (or, 2) in this process.
DIRECTED SEARCH FOR COMPOUNDS THAT AFFECT THE EXCRETORY FUNCTION OF RAT KIDNEYS, AMONG NEW CYCLOALKYLCARBONYL THIOUREAS AND THIOSEMICARBAZIDES DERIVATIVES

Introduction. Prolonged usage of diuretics, especially in large doses, the number and severity of side effects (water-electrolyte and metabolic disorders), as well as the relatively limited range of existing diuretics dictate the need to find new compounds that would have diuretic effects, simple production technology and would be safer. The aim of the study – directed search for diuretics among unknown disubstituted thioureas and thiosemicarbazides using the molecular docking methodology as the way to explain the probable mechanism of action. Research Methods. The structures of the target compounds have been proposed using drug-design approaches, namely the introduction of structural fragments into thioureas and thiosemicarbazides, which are characteristic of known diuretics. The synthesis of substituted cycloalkylcarbonylthioureas or thiosemicarbazides was carried out by a single-reactor method using cycloalkylcarbonyl chlorides, ammonium isothiocyanate and substituted anilines or carboxylic acid hydrazides. The structure of the synthesized compounds was proved by IR, 1H NMR spectroscopy, chromato-mass spectrometry and elemental analysis. Probable molecular mechanisms of activity were predicted due to molecular docking. Directed search for compounds that affect the excretory function of the kidneys of rats was conducted by the conventional method of E.B. Berkhin with water load. Results and Discussion. It has been found that the single-reaction of cycloalkylcarbonyl chlorides with an equimolecular amount of ammonium isothiocyanate and substituted anilines or carboxylic acid hydrazides resulted in formation of substituted cycloalkylcarbonylthioureas or thiosemicarbazides. The structure of the synthesized compounds was discussed using IR, 1H NMR and chromato-mass spectra. Studies of the effect of the synthesized compounds on the excretory function of rats kidneys under water load have revealed several compounds that exceed the diuretic effect of “Furosemide” and compete with “Hydrochlorothiazide”. Molecular docking results have shown that the test compounds demonstrated a high affinity for carbonic anhydrase II and similar binding sites to reference drugs. This indicates their probable mechanism of action. Conclusion. The developed and implemented strategy for searching of diuretics among cycloalkylcarbonyl thioureas and thiosemicarbazides derivatives has allowed to identify an effective compound (3.2), which is close to the reference drug “Hydrochlorothiazide” in terms of diuretic effect. Importantly, according to the results of molecular docking, the synthesized compounds as well as the reference drugs have a similar mechanism of action (carbonic anhydrase II inhibitors). It is likely, that the expressed diuretic effect of several compounds is related to the ability of substituted thioureas to form coordination bonds with the zinc cation in the active site of CA II. The obtained results substantiate the further purposeful search for potential diuretics among this class of compounds.
Tele-Monitoring and Control Through the World Wide Web: Issues and Development *

: The Internet and the World Wide Web (WWW) provide low cost and widely available media rich interface that can make teleoperated resources accessible to a broad range of users regardless of geographic location. In addition, Internet based teleoperation with tools supporting human communication and interaction with real world, will inevitably lead to many useful applications in various sectors of the society, professionally and socially. This will lead to improve quality of services, utilise efficiently resources, minimise risk associated with hazardous and dangerous environments, access timely information and expertise that support diagnosis and decision making, and to reduce overall operational and maintenance cost. This paper addresses the technical issues and requirements that affect the design, acceptability and performance of Internet based teleoperated systems. Such issues include, communication and the effect of delay, controllability, reliability, interfacing requirements, command structure along with software and hardware compatibility. Also, consideration is given to monitor and control one or group of equipment/process at a single site and at multiple sites. A framework that supports Internet based monitoring and control systems has been developed. The goal was to design a system that would be versatile, easy to learn and use, and that would allow several users to simultaneously view and control distributed equipment, appliances, utilities, etc. Two applications are selected and implemented to demonstrate the developed system. The first is to monitor, program and control a robot manipulator, and the second is to monitor and control house appliances and utilities available on-site. The developed system is written in Java language and is accessible via a Web browser.
Method for Screening of Quorum Sensing Inhibitors

The present invention relates to a screening method of a quorum sensing inhibitor using a vector and the vector is introduced strains comprising the expression cassette for screening of the quorum sensing (Quorum sensing) inhibitors. Specifically, the acyl-homoserine gene lactone recognition to encode transcriptional regulatory proteins that bind to the gene encoding antibiotic inhibitor protein operably linked to a promoter which transcription is controlled by said transcriptional regulatory protein, and decomposing the antibiotic comprising a gene encoding an antibiotic-degrading enzymes are delivered are active by the inhibitor proteins, quorum sensing vector comprising the inhibitors in an expression cassette for screening, the transformed strain with the vector, a quorum sensing inhibitor candidate to the strain substances and by relates to a quorum sensing inhibitor screening by the method and the method for screening a quorum sensing inhibitor contact. Quorum sensing, an acyl homoserine lactone, LuxI, LuxR, β- lactamase inhibitory protein, TEM-1 β- lactamase
Classifying texts through natural language parsing and semantic filtering

This paper presents a study in text classiﬁcation through semantic and syntactic natural language processing. The authors have used a parser for French, SYGFRAN, and applied it to a real project of press articles classiﬁcation. The results of this research on a corpus of 4 , 843 texts containing more than 76 , 000 sentences are described. Classiﬁcation into 37 categories has been obtained through meaning discrimination by semantic ﬁltering techniques, explained in the document.
Scheduling NASA’s Deep Space Network: Priorities, Preferences, and Optimization

NASA’s Deep Space Network (DSN) is the primary resource for communications and navigation for inter-planetary space missions, for both NASA and partner agencies. Growth in mission demand, both in number of spacecraft and in data return, has led to increased loading levels on the network, and actual demand frequently exceeds network capacity. The DSN scheduling process involves peer-to-peer collaborative negotiation, which consumes signiﬁcant time and resources in order to reach a baseline version of the schedule, and then to manage and agree to changes. Process delays are exacerbated by the high level of oversubscription experienced by the DSN: it is not unusual for the scheduling process to start with 20-40% more requested time can be accommodated on the available antennas. The other NASA networks make use of a static mission priority list to address a similar problem: missions are ranked in priority order, then the schedule is populated by priority from highest to lowest. Such a mechanism would not work for DSN due to the heterogeneity of the mission set, and to the time-varying mission requirements with mission phase. This paper describes an alternative approach for the DSN that addresses key problems inherent in the current process — oversubsubscription and how to “fairly” reduce it to a manageable level. The main characteristics of the new approach are the use of loading-based limits based on balancing requested time, along with priorities and user preferences as the basis for optimization criteria that can be used by new algorithms.
TEACHER-RELATED FACTORS IN INTEGRATING INFORMATION AND COMMUNICATION TECHNOLOGY IN SECONDARY EDUCATION: A PARTIAL LEAST SQUARES STRUCTURAL EQUATION MODELING APPROACH

This study compared integration of information and communication technology (as computer use) between secondary school mathematics and non-mathematics. A survey consisting of items on demographic information, computer use experience and five technology acceptance variables (computer self-efficacy, Teacher efficacy, Attitude towards computer, Social influence and Constructivist belief) was used for data collection. Data from 400 teacher respondents was used for analysis. WarpPLS 4.0 software was used to conduct the analyses for PLS-SEM and Multigroup comparison using MS Excel. Results show that computer self-efficacy had significant direct effect on computer use; moderated by age and computer experience for mathematics and non-mathematics teachers respectively. Teacher efficacy had a negative significant relationship with computer use for mathematics teacher sub-sample moderated by gender and age. Attitude towards computer had a positive total effect on computer use for the mathematics teacher sub-sample mediated by computer self-efficacy and moderated by gender. Social influence had a significant positive total effect on computer use for the non-mathematics teacher sub-sample moderated by age. Constructivist belief revealed inconsistent relationship with computer use (positive for non-mathematics teacher sub-sample and negative for mathematics teacher sample) with computer self-efficacy as a mediator of this relationship in the non-mathematics teacher sample.