Miracle-dz/UniFAR-FTUs huggingface dataset:
A security scheme based on blockchain and a hybrid cryptosystem to reduce packet loss in IoV

The internet of vehicles is a future technology that uses autonomous vehicles and road infrastructure to provide convenience to drivers and prevent accidents caused by driver negligence. However, autonomous vehicles are vulnerable to network attacks because they collect information using wireless communication. An attacker penetrates the autonomous vehicle's network to drop information or forge and retransmit information. An autonomous vehicle that collects forged information may cause an accident due to incorrect driving. A scheme applying blockchain to the internet of vehicles has been proposed to prevent attacks occurring on autonomous vehicles. Blockchain has excellent security and has better performance when operating in a small network. However, blockchain is difficult to operate in a large network, and it takes a long time to encrypt and decrypt messages. Blockchain technology can cause packet loss when used in environments with many driving vehicles. In this paper, we solve the packet loss problem using a security scheme that combines blockchain and a hybrid cryptosystem. The proposed scheme constructs a block chain with only the road infrastructure and verifies information through a control center. Autonomous vehicles use the hybrid cryptosystem to collect information while maintaining security. In the proposed scheme, the time consumed for encryption/decryption can be reduced by using a hybrid cryptosystem. As a result of the experiment, the proposed scheme reduces accidents caused by packet loss by about 80% compared to the existing scheme using a private block chain.
Means and Mechanism of the Realization of Linguistic Subjectivity from the Perspective of Philosophical Cognition

This study discusses the linguistic subjectivity (LS) phenomenon from the perspective of philosophical cognition. The purpose of this study is to explore the human’s cognitive styles and ways of existence in language and to deepen the understanding of communicative functions of language. An interactive geometric research framework of LS was constructed and the means and mechanism of its realization were explored at six levels: language system level, language use level, propositional meaning level, non-propositional meaning level, speaker’s encoded meaning level and hearer’s decoded meaning level. Also, three dimensions were covered: lexical dimension, syntactic dimension, and discourse dimension. Results show that humans’ cognitive styles and ways of existence encoded in language can be more profoundly dug by exploring LS from the perspective of philosophical cognition. The study can provide a feasible analytical framework for systematically and comprehensively probing of LS phenomenon. Thus, the study facilitates a deeper understanding of LS and communicative functions of language. The study also thoroughly mines subjective factors behind the speaker’s words, utterances or discourse, such as attitudes, emotions and feelings, which also belong to the cognition category, indicating the speaker’s existence in language.
EXTENDED SERVICE CONTRACTS

Automobile extended service contracts (ESCs) have been in existence for many years. Due to the nature of the coverage, an insurer may not know the actual results for a particular book for some time afer the book has been in place. This paper discusses this coverage and unique characteristics of ESCs that should be recognized when analyzing experience for an ESC program. The paper also discusses some approaches that have been used to address these problems and to derive reserve and rate estimates for ESC programs.
Neuromuscular Characteristics and Physical Function in Participants with Parkinson’s Disease

PURPOSE: This study aimed to investigate the level of physical function, lower body strength, and muscle activation during various types of muscle contraction in participants with and without Parkinson’s disease (PD). METHODS: Twelve participants with PD (mean age=63.17±6.24 years) and 12 age- and sex-matched healthy adults (mean age = 58.67±6.39 years) were recruited. An isokinetic dynamometer was used to measure the length- and velocity-dependent maximum voluntary force and the rate of torque development (RTD) of the knee extensor muscles. Muscle activation of the vastus lateralis (VL), vastus medialis (VM), and rectus femoris (RF) muscles of both legs was examined using surface electromyography. The 6-minute walk test, chair stand test, timed up-and-go test, sit-and-reach test, and back-scratch test were performed to assess physical function.RESULTS: Compared to healthy individuals, participants with PD showed significantly lower maximum voluntary force and RTD (p<.05), performed fewer repetitions in the chair stand test (11.64±1.75 vs. 17.08±2.27, p<.001), were slower in the timed up-andgo test (8.36±1.42 vs. 5.65±1.07, p<.001), and walked shorter distances in the 6-minute walk test (424.17±65.97 vs. 539.47±63.18, p<.001). However, activation of the three different muscles during isometric and isokinetic muscle contraction was not different between participants with and without PD.CONCLUSIONS: Preserved muscle activation and significantly lower muscle strength during various types of muscle contractions may suggest lower muscle strength and efficiency. The lower physical function seen in participants with mild PD could be due to disease and low physical activity-related muscle atrophy rather than lower muscle activation.
A Composite Four-Factor Model in China

We investigate investors’ overreaction and underreaction and their implications to asset pricing in China stock market. The study first picks anomaly variables representing investors’ overreaction and underreaction and then measures these two effects quantitatively. Both of them deliver significant excess returns, both statistically and economically, in China stock market. We then equip these two effects with the market and the size factor to construct a composite four-factor model and study how they price other assets. Extensive empirical analysis shows that this new model is suitable for China stock market. The maximum annual Sharpe ratio spanned by the four factors is 2.02, which is one time higher than those spanned by similar models such as Stambaugh and Yuan (2017) and Daniel, Hirshleifer and Sun (2020). In addition, using 149 anomaly candidates as test assets, the composite four-factor model exhibit good pricing capability, as there is only one test asset whose abnormal return given the model exceeds the 3.0 t-statistic threshold.
Trading Simulation Strategy: How Does the Amount of Information Used, and Sentiment Affect a Portfolios Net Performance

This research will look over a dataset which contains 352 observations and 36 variables which is derived from a investment trading simulation where individuals are given information about a select group of companies that they are able to trade on, and are given a timeframe where they can trade which is accelerated, and they have to do their best to be as successful as they can within this time frame. This analysis will look over multiple variables and the affect that they have on each individual’s net performance at the end of the simulation, and the answers that they gave in the end of simulation survey which explains a little bit about how they went about this simulation and how much information they used when making their investing decisions. Most of this analysis will revolve around the strategy that each of the individuals used throughout the simulation and how the different variables within each strategy affected the net performance when comparing it to overall performance.
Can the Changes in Fundamentals Explain the Attenuation of Investment-Related Anomalies

The existing literature attributes the recent decay of stock market anomalies to increased arbitrage (e.g., Chordia, Subrahmanyam and Tong, 2014; Engelberg, McLean and Pontiff, 2016; Green, Hand and Zhang, 2016). In this paper, we present evidence that the apparent demise of several prominent classes of stock market anomalies is better explained by changes in underlying fundamentals. The differences in subsequent fundamental performance between the long- and short-leg portfolios, as measured by standardized seasonally differenced return on average assets (SDROA), decrease substantially after 2003 for the financing, investment and accruals anomalies we examine. We find that quarterly stock return can predict SDROAs up to four quarters ahead and that the decline in SDROA spreads is accompanied by a decline in the investment spreads between the long- and short-leg portfolios. These results are consistent with the q-theory of investment, which attributes the attenuation of these anomalies to time variation in discount rates. We provide evidence that the time variation in discount rates is associated with increased uncertainty. We also show that neither changes in analyst forecast errors nor proxies for increased arbitrage can explain the attenuation of these anomalies.
Treosulfan-Based Conditioning Regimen Prior to Allogeneic Stem Cell Transplantation: Long-Term Results From a Phase 2 Clinical Trial

Introduction Reducing toxicities while preserving efficacy in allogeneic stem cell transplant (allo-HCT) remains a particularly challenging problem. Different strategies to enhance the antitumor activity without increasing early and late adverse toxicities of the conditioning regimens have been investigated. Methods The aim of “AlloTreo” prospective phase 2 clinical trial was to evaluate the efficacy and safety of a conditioning regimen based on Treosulfan (42 g/m2) and fludarabine (https://clinicaltrials.gov/ct2/show/NCT00598624). We enrolled 108 patients with hematological diseases who received a first allo-HCT between June 2005 and January 2011, inside the frame of this trial at our center. Median age at allo-HCT was 49 (21–69) years. Disease Risk Index was low in 14 (13%) patients, intermediate in 73 (67.7%), high in 17 (15.7%), and very high in 4 (3.7%). Donors were human leukocyte antigen (HLA)-matched related in 50 cases, 10/10-matched unrelated in 36, and 9/10-mismatched unrelated in 22. Graft-versus-host disease (GvHD) prophylaxis consisted of cyclosporine-A and methotrexate. Anti-T-lymphocyte globulin (ATLG) was administered in patients receiving unrelated allo-HCT. Stem cell source was mainly peripheral blood stem cells (95%). Results Conditioning regimen was well tolerated. Full donor chimerism was documented for most patients (88%) at day +30. At 12 years, overall survival (OS) was 41.7% (32.2%–50.9%), progression-free survival (PFS) was 31.7% (23%–40.7%), GvHD-free/relapse-free survival was 20.9% (13.7%–29.1%), cumulative incidence (CI) of relapse was 44.5% (34.9%–53.6%), and transplant-related mortality (TRM) was 22.5% (15.1%–30.9%). CI of acute GvHD grades II–IV was 27.8% (19.7%–36.5%) at 100 days; 12-year CI of chronic GvHD was 40.7% (31.3%–49.9%). Relevant long-term adverse effects were 10 secondary malignancy, 3 fatal cardiovascular events, and 1 late-onset transplant-associated thrombotic microangiopathy. Ten successful pregnancies were reported after allo-HCT. In multivariate analysis, older age (≥60 years) at transplant [hazard ratio (HR), 2.157; p = 0.004] and a high/very high disease risk index (HR, 1.913; p = 0.026) were significantly associated with a lower OS. Conclusions Overall, our data confirmed the myeloablative potential and safe toxicity profile of full dose Treo (42 g/m2) especially for the younger population.
The MoveStrong program for promoting balance and functional strength training and adequate protein intake in pre-frail older adults: A pilot randomized controlled trial

Background Balance and functional strength training can improve muscle strength and physical functioning outcomes and decrease the risk of falls in older adults. To maximize the benefits of strength training, adequate protein intake is also important. However, the number of older individuals that consume enough protein or routinely engage in strength training remains low at less than 5% and even lower for activities that challenge balance. Our primary aim was to assess the feasibility of implementing a model (MoveStrong) of service delivery to teach older adults about balance and functional strength training and methods to increase protein intake. Methods This study was a closed cohort stepped wedge randomized controlled trial. We recruited individuals ≥60 years considered pre-frail or frail with at least one chronic condition who were not currently engaging in regular strength training from Northern (rural) and Southern (urban) Ontario sites in Canada. The primary outcome was feasibility of implementation, defined by recruitment, retention, and adherence, and safety (defined by monitoring adverse events). We also reported participants’ and providers’ experience with MoveStrong, adaptations to the model based on participant’s and provider’s experience, and program fidelity. Results We recruited 44 participants to the study and the average adherence rate was 72% with a retention of 71%. The program had a high-fidelity score. One person experienced a fall-related injury during exercise, while two other participants reported pain during certain activities. Five individuals experienced injuries or health problems that were not related to the program. Suggestions for future trials include modifying some exercises, exploring volunteer assistance, increasing the diversity of participants enrolled, and considering a different study design. Conclusions Our pilot trial demonstrates the feasibility of recruitment and adherence for a larger multisite RCT of balance and functional strength training with attention to protein intake in pre-frail and frail older adults.
Platelet-Rich Plasma with Microneedling in Androgenetic Alopecia: Study of Efficacy of the Treatment and the Number of Sessions Required

Abstract Background: Platelet-rich plasma (PRP) is a simple and safe procedure, which has been used for soft tissue and wound healing. PRP has been used in dermatology for skin rejuvenation and alopecia. Objective: The objective of our study was to study efficacy of PRP with microneedling in patients with androgenetic alopecia (AGA) and to assess number of sessions required for a patient. Materials and Methods: Sixty patients diagnosed with AGA were studied between August 2016 and October 2018 who did not respond to minoxidil and finasteride. PRP was prepared by centrifugation of patients’ blood. PRP with microneedling was done for all patients under aseptic conditions. Four to six sessions were done at an interval of 4 weeks. Subjective and objective scores were assessed based on a visual analog global score. Assessment was done at the first session, every next sitting, and 4 weeks after the last sitting. Follow-up was done at 3rd and 6th month after the last sitting. Results: According to subjective scores, two patients (3.33%) had excellent results, 24 (40%) very good, 22 (36.6%) good, 6 (10%) fair results, and 6 (10%) did not have any response. Objective assessment scores showed that two patients (3.33%) had excellent results, 26 (43.3%) very good, 21 (35%) good, 7 (11.6%) had fair results, and 4 (6.7%) did not have any response. Fifty patients underwent four sessions out of which 40 (i.e. 66%) patients had very good results. Only 10 patients required more than four sessions to achieve good results. Patients were happy with four sessions. There were no side effects noted either during or after the treatment. Conclusion: This study shows PRP with microneedling as an efficacious treatment for AGA and augments the effects of conventional treatment. This study sets example for assessing the number of PRP sessions. A minimum of four sessions is required to achieve very good results.
Influence of first colostrum pasteurization on serum immunoglobulin G, iron, and activity of gamma-glutamyltransferase in newborn dairy calves

Abstract Background and Aim: Colostrum pasteurization is an established procedure in dairy farms in developed countries. This practice can improve the health status of the offspring by reducing several pathogens. This study aimed to focus on the pasteurization of bovine first colostrum and its influence on certain important bioactive components. Materials and Methods: This study was conducted in Holstein-Friesian bull calves, which were randomly divided into two groups and fed with 6 L of untreated (UT, n=10) or 6 L of heat-treated (HT, 63.5°C for 30 min, n=10) colostrum from their own dam within the first 12 h after birth. Blood samples were taken before, 24 h, and 48 h after first colostrum intake to determine the concentrations of immunoglobulin G (IgG) and iron and the activity of gamma-glutamyltransferase (GGT) in the serum. Results: The level of IgG was not affected by pasteurization (p=0.19). However, a slower increase in GGT activity (p<0.05) and a lower serum iron concentration (p=0.04) were observed in the HT group. Conclusion: It can be concluded that pasteurization influences the absorption of colostrum components and therefore, the passive transfer of immunity, although the level of IgG was not affected by pasteurization in this study.
Direct administration of the non-competitive interleukin-1 receptor antagonist rytvela transiently reduced intrauterine inflammation in an extremely preterm sheep model of chorioamnionitis

Background Intraamniotic inflammation is associated with up to 40% of preterm births, most notably in deliveries occurring prior to 32 weeks’ gestation. Despite this, there are few treatment options allowing the prevention of preterm birth and associated fetal injury. Recent studies have shown that the small, non-competitive allosteric interleukin (IL)-1 receptor inhibitor, rytvela, may be of use in resolving inflammation associated with preterm birth (PTB) and fetal injury. We aimed to use an extremely preterm sheep model of chorioamnionitis to investigate the anti-inflammatory efficacy of rytvela in response to established intra-amniotic (IA) lipopolysaccharide (LPS) exposure. We hypothesized that rytvela would reduce LPS-induced IA inflammation in amniotic fluid (AF) and fetal tissues. Methods Sheep with a single fetus at 95 days gestation (estimated fetal weight 1.0 kg) had surgery to place fetal jugular and IA catheters. Animals were recovered for 48 hours before being randomized to either: i) IA administration of 2 ml saline 24 hours before 2 ml IA and 2 ml fetal intravenous (IV) administration of saline (Saline Group, n = 7); ii) IA administration of 10 mg LPS in 2 ml saline 24 hours before 2 ml IA and 2 ml fetal IV saline (LPS Group, n = 10); 3) IA administration of 10 mg LPS in 2 ml saline 24 hours before 0.3 mg/fetal kg IA and 1 mg/fetal kg fetal IV rytvela in 2 ml saline, respectively (LPS + rytvela Group, n = 7). Serial AF samples were collected for 120 h. Inflammatory responses were characterized by quantitative polymerase chain reaction (qPCR), histology, fluorescent immunohistochemistry, enzyme-linked inmmunosorbent assay (ELISA), fluorescent western blotting and blood chemistry analysis. Results LPS-treated animals had endotoxin and AF monocyte chemoattractant protein (MCP)-1 concentrations that were significantly higher at 24 hours (immediately prior to rytvela administration) relative to values from Saline Group animals. Following rytvela administration, the average MCP-1 concentrations in the AF were significantly lower in the LPS + rytvela Group relative to in the LPS Group. In delivery samples, the expression of IL-1β in fetal skin was significantly lower in the LPS + rytvela Group compared to the LPS Group. Conclusion A single dose of rytvela was associated with partial, modest inhibition in the expression of a panel of cytokines/chemokines in fetal tissues undergoing an active inflammatory response.
MONTI: A Multi-Omics Non-negative Tensor Decomposition Framework for Gene-Level Integrative Analysis

Multi-omics data is frequently measured to enrich the comprehension of biological mechanisms underlying certain phenotypes. However, due to the complex relations and high dimension of multi-omics data, it is difficult to associate omics features to certain biological traits of interest. For example, the clinically valuable breast cancer subtypes are well-defined at the molecular level, but are poorly classified using gene expression data. Here, we propose a multi-omics analysis method called MONTI (Multi-Omics Non-negative Tensor decomposition for Integrative analysis), which goal is to select multi-omics features that are able to represent trait specific characteristics. Here, we demonstrate the strength of multi-omics integrated analysis in terms of cancer subtyping. The multi-omics data are first integrated in a biologically meaningful manner to form a three dimensional tensor, which is then decomposed using a non-negative tensor decomposition method. From the result, MONTI selects highly informative subtype specific multi-omics features. MONTI was applied to three case studies of 597 breast cancer, 314 colon cancer, and 305 stomach cancer cohorts. For all the case studies, we found that the subtype classification accuracy significantly improved when utilizing all available multi-omics data. MONTI was able to detect subtype specific gene sets that showed to be strongly regulated by certain omics, from which correlation between omics types could be inferred. Furthermore, various clinical attributes of nine cancer types were analyzed using MONTI, which showed that some clinical attributes could be well explained using multi-omics data. We demonstrated that integrating multi-omics data in a gene centric manner improves detecting cancer subtype specific features and other clinical features, which may be used to further understand the molecular characteristics of interest. The software and data used in this study are available at: https://github.com/inukj/MONTI.
Stable Long-Term Culture of Human Distal Airway Stem Cells for Transplantation

There is a population of p63+/Krt5+ distal airway stem cells (DASCs) quiescently located in the airway basal epithelium of mammals, responding to injury and airway epithelial regeneration. They hold the ability to differentiate into multiple pulmonary cell types and can repopulate the epithelium after damage. The current study aims at gaining further insights into the behavior and characteristics of the DASCs isolated from the patient lung and exploring their clinical translational potential. Human DASCs were brushed off through the bronchoscopic procedure and expanded under the pharmaceutical-grade condition. Their phenotype stability in long-term cell culture was analyzed, followed by safety evaluation and tumorigenic analysis using multiple animal models including rodents and nonhuman primate. The chimerism of the human-mouse lung model indicated that DASC pedigrees could give rise to multiple epithelial types, including type I alveolar cells as well as bronchiolar secretory cells, to regenerate the distal lung. Taken together, the results suggested that DASC transplantation could be a promising therapeutic approach for unmet needs in respiratory medicine including the COVID-19-related diseases.