Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular characterization of an MLL1 fusion and its role in chromosomal instability

Chromosomal rearrangements involving the mixed‐lineage leukemia (MLL1) gene are common in a unique group of acute leukemias, with more than 100 fusion partners in this malignancy alone. However, do these fusions occur or have a role in solid tumors? We performed extensive network analyses of MLL1‐fusion partners in patient datasets, revealing that multiple MLL1‐fusion partners exhibited significant interactions with the androgen‐receptor signaling pathway. Further exploration of tumor sequence data from TCGA predicts the presence of MLL1 fusions with truncated SET domain in prostate tumors. To investigate the physiological relevance of MLL1 fusions in solid tumors, we engineered a truncated version of MLL1 by fusing it with one of its known fusion partners, ZC3H13, to use as a model system. Functional characterization with cell‐based assays revealed that MLL1‐ZC3H13 fusion induced chromosomal instability, affected mitotic progression, and enhanced tumorsphere formation. The MLL1‐ZC3H13 chimera consistently increased the expression of a cancer stem cell marker (CD44); in addition, we detected potential collateral lethality between DOT1L and MLL1 fusions. Our work reveals that MLL1 fusions are likely prevalent in solid tumors and exhibit a potential pro‐tumorigenic role.
Relación entre el color de las cáscaras y las características del fruto y jugo de la parchita maracuyá

Relationship between skin color and fruit and juice characteristics of passion fruit Passion fruits were harvested at 55, 65, and 75 days after anthesis and analyzed for physical and chemical characteristics of fruit and juice, and color of the skin by reflectometry. Skin color became bright yellow with age, showing higher brightness (L*) and chrome (Cr*), and lower Hue (Hue*). The L*, Cr* and Hue* where related to the percentage of peel and juice, TSS/TTA, ascorbic acid and total sugar contents. The peel color was not related to TSS, TTA and pH. Chrome of the yellow portion was related to neither fruit nor juice characteristics.
Physical disability in community-dwelling older people after hip fracture : randomized controlled trials with physical rehabilitation

Edgren, Johanna Physical Disability in Community-Dwelling Older People after Hip Fracture Randomized Controlled Trials with Physical Rehabilitation Jyvaskyla: University of Jyvaskyla, 2013, 109 p. (Studies in Sport, Physical Education, and Health ISSN; 0356-1070; 201) ISBN 978-951-39-5478-9 (nid.) ISBN 978-951-39-5479-6 (PDF) Finnish summary Diss. Less than half of the hip fracture survivors will regain their pre-fracture level of physical functional capacity. The purpose of this study was to investigate the effects of progressive resistance training and the effects of multi-component homebased rehabilitation among older people who had sustained a hip fracture. Additionally, the associations of decreased balance confidence and impaired functional balance in relation to physical disability were studied. This study reports the results of two randomized controlled trials. The participants were community-dwelling men and women aged 60 and 60+. Of the 159 participants, 43 participated in 3-month resistance training (Hip Asymmetry). Additionally, 81 participated in a 1-year multi-component homebased rehabilitation program (ProMo). Physical disability (ADL and IADL) was assessed by a questionnaire. Balance confidence was assessed by the ABC Scale and functional balance by Berg Balance Scale. In the Hip Asymmetry study the measurements were performed before and after the training period and in the ProMo study at baseline and 3, 6, and 12 months thereafter. Balance confidence and functional balance were strongly associated with physical disability. Theoretically, a ten-point decrease in the ABC score increased the risk for disability by 10% (IRR 0.99; 95% CI 0.98–0.99) while the same decrease in the Berg score increased the risk for disability by 20% (0.98; 0.96–0.99). Resistance training improved independence especially in ADL (ANCOVA p=0.034). Home-based multi-component rehabilitation did not have a wide-ranging effect on disability. However, for the single disability items, borderline significant positive effects were observed for preparing food and handling medication (interaction p=0.061 and p=0.061, respectively). Additionally, the per-protocol analysis suggested that home-based multi-component rehabilitation may reduce ADL and IADL disability extensively. Balance confidence and functional balance were strongly associated with physical disability. Additionally, the results indicate a beneficial effect of resistance training on physical disability. Multi-component home-based rehabilitation may also reduce both ADL and IADL disability more broadly.
A long time radiological follow-up of neuronal intranuclear inclusion disease

Rationale: Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disease identified with diffusion-weighted imaging (DWI) high-intensity signal in magnetic resonance imaging (MRI). The disappearance of the abnormal signal is extremely rare. Patient concerns: We present the 2 cases of patients, both of them were suffering from heterogeneous symptoms. We followed up one of them for 7 years with MRI, the other accepted comprehensive MRI inspections. Diagnoses: DWI high-intensity signal were observed along the corticomedullary junction in MRI plan scan of heads of 2 patients. For patient 1, the hyperintensities in DWI and fluid-attenuated inversion recovery (FLAIR) images in the occipital lobe disappeared 5 years after onset. Based on the biopsy, patient 1 and 2 were diagnosed as NIID. Interventions: There have not effective medication and prevention for NIID. Patient 1 and 2 received symptomatic treatment. Outcomes: Up until now, the patients are alive but the disease is progressing. Lessons: DWI high-intensity signal is a strong clue for the diagnosis of NIID, but the rare case of the disappearance of it may lead to misdiagnosis.
Association between life span and body condition in neutered client‐owned dogs

Background There is an association between overweight status and life span in kenneled dogs, but a similar association has not been reported for pet dogs. Objectives To examine the effects of being overweight in middle age on the life span of neutered client‐owned dogs. Animals Fifty‐thousand seven‐hundred eighty seven middle‐aged neutered client‐owned dogs attending a network of approximately 900 veterinary hospitals across North America. Methods Retrospective case‐control study. For each of 12 breeds, groups of dogs aged between 6.5 and 8.5 years were identified as being in “overweight” or “normal” body condition. Within each breed and sex, differences in life span between dogs in normal body condition and overweight body condition in the 2 groups were then analyzed by Cox proportional hazards models. Results For all breeds, instantaneous risk of death for dogs in overweight body condition was greater than those in normal body condition throughout the age range studied, with hazard ratios ranging from 1.35 (99.79% confidence interval [CI] 1.05‐1.73) for German Shepherd dog to 2.86 (99.79% CI 2.14‐3.83) for Yorkshire Terrier. In all breeds, median life span was shorter in overweight compared with normal weight dogs, with the difference being greatest in Yorkshire Terriers (overweight: 13.7 years, 99.79% CI 13.3‐14.2; normal: 16.2 years, 99.79% CI 15.7‐16.5) and least in German Shepherd dogs (overweight: 12.1 years, 99.79% CI 11.8‐12.4; normal: 12.5 years, 99.79% CI 12.2‐12.9). Conclusions and Clinical Importance Veterinary professionals should consider promoting healthy body condition for dogs, particularly from midlife onward.
Clinical and Molecular Features of Feline Foamy Virus and Feline Leukemia Virus Co-Infection in Naturally-Infected Cats

Feline foamy virus (FFV) and feline leukemia virus (FeLV) belong to the Retroviridae family. While disease has not been reported for FFV infection, FeLV infection can cause anemia and immunosuppression (progressive infection). Co-infection with FFV/FeLV allows evaluation of the pathogenic potential and epidemiology of FFV infection in cats with FeLV pathology. Blood and buccal swab samples from 81 cats were collected in Rio de Janeiro. Plasma was serologically tested for FeLV. DNA extracted from peripheral blood mononuclear cells and buccal swabs was used to PCR detect FFV and FeLV. A qPCR was developed to detect and measure FFV proviral loads (pVLs) in cats. FeLV qPCR was performed using previous methods. The median log10 pVL of FFV mono-infected individuals was lower than found in FFV/FeLV co-infected cats in buccal swabs (p = 0.003). We found 78% of cats had detectable buccal FFV DNA in FFV mono-infected and FFV co-infected FeLV-progressive cats, while in FeLV-regressive cats (those without signs of disease) 22% of cats had detectable buccal FFV DNA (p = 0.004). Our results suggest that regressive FeLV infection may reduce FFV saliva transmission, the main mode of FV transmission. We did not find evidence of differences in pathogenicity in FFV mono- and -dually infected cats. In summary, we show that FVs may interact with FeLV within the same host. Our study supports the utility of cats naturally co-infected with retroviruses as a model to investigate the impact of FV on immunocompromised mammalian hosts.
Large packet switch and contention resolution device

We propose a way of combining several space division switching planes to build a larger switch with a total capacity which grows linearly with the number of switching planes. This can be made possible by resolving contention several times faster than the rate at which packets are switched through one plane. We couId for example combine eight 155 Mbit/sec IKXIK switching planes into a 1.24 Gbit/sec per input IKXIK switch, We propose a contention resolution scheme which can be implemented in current CMOS technology and can resolve contention for up to 16384 input lines in 2.33 psec. Contention can be resolved in shorter times for a proportionately smaller number Of inputs.
Hydrogen Sulfide-Mediated Activation of O-Acetylserine (Thiol) Lyase and l/d-Cysteine Desulfhydrase Enhance Dehydration Tolerance in Eruca sativa Mill

Hydrogen sulfide (H2S) has emerged as an important signaling molecule and plays a significant role during different environmental stresses in plants. The present work was carried out to explore the potential role of H2S in reversal of dehydration stress-inhibited O-acetylserine (thiol) lyase (OAS-TL), l-cysteine desulfhydrase (LCD), and d-cysteine desulfhydrase (DCD) response in arugula (Eruca sativa Mill.) plants. Dehydration-stressed plants exhibited reduced water status and increased levels of hydrogen peroxide (H2O2) and superoxide (O2•−) content that increased membrane permeability and lipid peroxidation, and caused a reduction in chlorophyll content. However, H2S donor sodium hydrosulfide (NaHS), at the rate of 2 mM, substantially reduced oxidative stress (lower H2O2 and O2•−) by upregulating activities of antioxidant enzymes (superoxide dismutase, peroxidase, and catalase) and increasing accumulation of osmolytes viz. proline and glycine betaine (GB). All these, together, resulted in reduced membrane permeability, lipid peroxidation, water loss, and improved hydration level of plants. The beneficial role of H2S in the tolerance of plants to dehydration stress was traced with H2S-mediated activation of carbonic anhydrase activity and enzyme involved in the biosynthesis of cysteine (Cys), such as OAS-TL. H2S-treated plants showed maximum Cys content. The exogenous application of H2S also induced the activity of LCD and DCD enzymes that assisted the plants to synthesize more H2S from accumulated Cys. Therefore, an adequate concentration of H2S was maintained, that improved the efficiency of plants to mitigate dehydration stress-induced alterations. The central role of H2S in the reversal of dehydration stress-induced damage was evident with the use of the H2S scavenger, hypotaurine.
Electronic cigarette usage patterns: a case study combining survey and social media data

Objective To identify who were social media active e-cigarette users, to compare the use patterns from both survey and social media data for data triangulation, and to jointly use both datasets to conduct a comprehensive analysis on e-cigarette future use intentions. Materials and Methods We jointly used an e-cigarette use online survey (n = 5132) and a social media dataset. We conducted analysis from 3 different perspectives. We analyzed online forum participation patterns using survey data. We compared e-cigarette use patterns, including brand and flavor types, ratings, and purchase approaches, between the 2 datasets. We used logistic regression to study intentions to use e-cigarettes using both datasets. Results Male and younger e-cigarette users were the most likely to participate in e-cigarette-related discussion forums. Forum active survey participants were hardcore vapers. The e-cigarette use patterns were similar in the online survey data and the social media data. Intention to use e-cigarettes was positively related to e-liquid ratings and flavor ratings. Social media provided a valuable source of information on users' ratings of e-cigarette refill liquids. Discussion For hardcore vapers, social media data were consistent with online survey data, which suggests that social media may be useful to study e-cigarette use behaviors and can serve as a useful complement to online survey research. We proposed an innovative framework for social media data triangulation in public health studies. Conclusion We illustrated how social media data, combined with online survey data, can serve as a new and rich information source for public health research.
Evaluation of Electroencephalogram Using Exact Low-Resolution Electromagnetic Tomography During Photic Driving Response in Patients with Migraine

Background: Photophobia is a common feature of migraine, which may involve abnormal cortical information processing. In electroencephalograms (EEG), photic driving is known as a reaction to visual stimulation. Both photophobia and photic driving response are present during light stimulation. We hypothesized that cortical response to photic stimulation would differ between migraine patients with and without aura. Methods: We recruited 50 migraine patients (migraine with aura [MWA] = 21; migraine without aura [MWOA] = 29). Spontaneous eyes-closed resting EEG from 20 electrodes on the scalp during the interictal phase was recorded. After recording, each photic stimulation was separately selected. We analyzed EEG by fast Fourier transform and observed the spectrum frequency peaks and topographies in response to photic stimulation. Exact low-resolution electromagnetic tomography (eLORETA) was used to compute the 3-dimensional intracerebral distribution of EEG activity. Results: Photic stimulation at frequencies 5, 8, 15, and 20 Hz showed significant differences between migraine patients with and without aura. MWOA patients consistently had a stronger response to photic stimulation than MWA patients. In all patients, the differential response was located in the visual cortex, except for the stimulation at 20 Hz, where the difference at subharmonic 10 Hz was located in the parietal cortex (Brodmann Area 7). Conclusion: We confirmed high incidences of photic hypersensitivity and photic driving responses in migraine patients. We suggest that repeated occurrences of cortical spreading depression in MWA may suppress cortical function, thus contributing to a weaker visual cortical response to photic stimulation in MWA patients compared with MWOA patients.
An Explanatory Model of Emotional Intelligence and Its Association with Stress, Burnout Syndrome, and Non-Verbal Communication in the University Teachers

The present study set out to define and contrast an explanatory model of perception of stress, the dimensions of burnout syndrome, emotional intelligence, and non-verbal communication in a sample of university teachers. A total of 1316 teachers from Spain, aged between 24 and 70 years (M = 45.64, SD = 10.33) and evenly distributed between both sexes, participated. The measurement instruments employed were the Perceived Stress Scale (PSS), the Maslach Burnout Inventory (MBI), the Trait Meta-Mood Scale (TMMS-24), and the Nonverbal Immediacy Scale (NIS) A structural equation model was produced that demonstrated adequate fit to the empirical data (130,259; df = 9; p < 0.001; CFI = 0.907; NIF = 0.914; IFI = 0.923; RMSEA = 0.077). Results revealed that stress relates positively with emotional exhaustion and negatively with personal fulfilment. Emotional exhaustion was associated directly with emotional attention and inversely with emotional clarity and emotional repair, with these being linked to personal fulfilment. Both emotional clarity and repair related positively with non-verbal communication. Conclusions from the present study are that emotional intelligence and body language are two relevant factors in the prevention of burnout syndrome, and as a result can help to ensure the mental wellbeing of university teachers.
Commutable whole blood reference materials for hemoglobin A1c validated on multiple clinical analyzers

Abstract Background The measurement of hemoglobin A1c (HbA1c) is important for diagnosing diabetes mellitus as well as assessing glycemic control in diabetic patients. Commutable whole blood certified reference materials (CRMs) are needed in the measurement of HbA1c for method validation and/or as quality controls. Methods We developed three levels of hemolyzed whole blood CRMs for HbA1c. The certified values were determined using liquid chromatography-isotope dilution tandem mass spectrometry method (LC-IDMS/MS) where two “signature” hexapeptides of HbA1c and hemoglobin A0 (HbA0) were used as the calibration standards. The concentrations of the hexapeptide solutions were determined by amino acid analysis by the LC-IDMS/MS method using amino acid CRMs as the calibration standards. The commutability study was conducted by measuring 25 patient specimens and the whole blood CRMs by both LC-IDMS/MS method and various routine methods using six different clinical analyzers. Results The certified values were determined to be 35.1±2.0, 50.3±1.9 and 65.8±2.6 mmol/mol, respectively. These CRMs showed good commutability on five of the six clinical analyzers but showed poor commutability on one of the clinical analyzers that used similar method as two other analyzers where good commutability was observed. Conclusions With certified target values based on metrological traceability and good commutability on most of the clinical analyzers, the developed whole blood CRMs can be used for method validation or as quality control materials in the measurement of HbA1c. The commutability study results also underscored the need of commutability testing of clinical CRMs using various clinical analyzers.
Carrier phase jitter sensitivity for single-carrier and multi-carrier QAM systems

Investigates how the carrier phase jitter of a phase-locked oscillator for IF-to-baseband conversion affects the performance of single-carrier QAM (SC-QAM) and multi-carrier QAM (MC-QAM). This phase jitter reduces the signal-to-noise ratio (SNR) at the input of the decision device, and therefore gives rise to an increase of the bit error rate. The authors show that, for a given jitter variance, SC-QAM and MC-QAM yield the same SNR degradation. However, when the synchronization for MC-QAM is derived from a pilot tone, the authors point out that the resulting jitter variance is considerably larger than for SC-QAM, in which case MC-QAM is degraded much more than SC-QAM.
Assess image blur in photoelectric imaging system

The difficulty for no-reference image quality assessment is the lack of the information of the reference image. With the analysis of the mathematical model of the photoelectric imaging system and the reason for image blur, a method is proposed for constructing reference images, and at the same time the Structural Similarity index is introduced into noreference image quality assessment. A novel no-reference image quality assessment index called No-Reference Structural Sharpness is then proposed for quality evaluation of blurred images. This method constructs a reference image by a low-pass filter, and assesses the image quality by computing the structural similarity index between the original image and the reference one, thus considering the mathematical model of imaging system as well as the advantages of Structural Similarity index. The experimental results show that the new index is well in accordance with quality assessment results of both subjective evaluation and full-reference methods.
Analyzing Fine-grained Hypertext Features for Enhanced Crawling and Topic Distillation.

Early Web search engines closely resembled Information Retrieval (IR) systems which had matured over several decades. Around 1996–1999, it became clear that the spontaneous formation of hyperlink communities in the Web graph had much to offer to Web search, leading to a flurry of research on hyperlink-based ranking of query responses. In this paper we show that, over and above inter-page hyperlinks, much semantic information can be teased out of the manner in which markup tags, such as menu-bars, tables, and lists are used to organize pages, and the context in which hyperlinks are made from a page to another. We believe that delving into fine-grained page structure will be the next wave in hypertext mining, bridging some of the gap between unstructured HTML and relatively structured XML, and preparing the stage for deeper analysis into page snippets. We talk about two applications to illustrate fine-grained page analysis: topic-guided focused crawling, and hyperlink-based ranking which takes page structure into account. In both cases, we show that exploiting fine-grained structure enhances the performance of our systems.
Unforgotten: Love and the Culture of Dementia Care in India

List of Illustrations List of Tables Acknowledgements Notes on Transliteration Introduction Chapter 1. Methods and Character Building Chapter 2. The Diagnostic Process Chapter 3. Therapeutics and Health Seeking Chapter 4. The Economies of Care Chapter 5. Alzheimer's and the Indian Appetite Chapter 6. Stigma and Loneliness in Care Chapter 7. The Journey to Silence Conclusion: 'This is the Time for Romance' Glossary References Index
Nanoindentation of Soft Biological Materials

Nanoindentation techniques, with high spatial resolution and force sensitivity, have recently been moved into the center of the spotlight for measuring the mechanical properties of biomaterials, especially bridging the scales from the molecular via the cellular and tissue all the way to the organ level, whereas characterizing soft biomaterials, especially down to biomolecules, is fraught with more pitfalls compared with the hard biomaterials. In this review we detail the constitutive behavior of soft biomaterials under nanoindentation (including AFM) and present the characteristics of experimental aspects in detail, such as the adaption of instrumentation and indentation response of soft biomaterials. We further show some applications, and discuss the challenges and perspectives related to nanoindentation of soft biomaterials, a technique that can pinpoint the mechanical properties of soft biomaterials for the scale-span is far-reaching for understanding biomechanics and mechanobiology.
Techniques of teaching English for engineers

The main purpose of this research is to present the teaching English for engineers with emphasis on the role of the communicative language teaching. In the global context, students of engineering need a specific set of language skills for their success in education and career. In the first part the paper describes the meaning of ESP and the professional requirements in the world of work. The second part of the paper discusses the importance of Internet in teaching communicative engineering English language and the final part illustrates the results and discussion of this topic.