Miracle-dz/UniFAR-FTUs huggingface dataset:
Extragastric gastrinoma or G‐cell hyperplasia of the antrum? The preoperative diagnosis in a case of hypergastrinaemia

A patient is described with recurrent peptic ulceration, evidence of hypersecretion of gastric acid and excess circulating gastrin. The preoperative differentiation between extragastric ‘gastrinoma’ and G‐cell hyperplasin of the pyloric antrum as a source for the hypergastrinaemia can be made by immunofluorescent staining of an antral biopsy for ‘gastrin cells’, and by measuring the response of the gastric antrum to an amino acid meal or secretin infusion stimulus. The site of excessive gastrin production determines the nature of the surgery required. A classification of recurrent peptic ulceration types is suggested.
A hybrid spatiotemporal and Hough-based motion estimation approach applied to magnetic resonance cardiac images

Myocardial motion analysis and quantification is of utmost importance for analyzing contractile heart abnormalities and it can be a symptom of a coronary artery disease. A fundamental problem in processing sequences of images is the computation of the optical flow, which is an approximation to the real image motion. This paper presents a new algorithm for optical flow estimation based on a spatiotemporal-frequency (STF) approach, more specifically on the computation of the Wigner-Ville distribution (WVD) and the Hough Transform (HT) of the motion sequences. The later is a well-known line and shape detection method very robust against incomplete data and noise. The rationale of using the HT in this context is because it provides a value of the displacement field from the STF representation. In addition, a probabilistic approach based on Gaussian mixtures has been implemented in order to improve the accuracy of the motion detection. Experimental results with synthetic sequences are compared against an implementation of the variational technique for local and global motion estimation, where it is shown that the results obtained here are accurate and robust to noise degradations. Real cardiac magnetic resonance images have been tested and evaluated with the current method.
Genetic Evidence for Multi-Event Imports of Avian Influenza Virus A (H5N1) into Bavaria, Germany

The almost simultaneous initial detections of avian influenza A H5N1 viruses in central Europe in February 2006, at a time devoid of migratory bird activity, raised the question of the origin of these viruses. This report presents molecular data from Europe providing evidence for multiple and spatially overlapping H5N1 introductions into Bavaria, Germany.
Quetiapine monotherapy as treatment for anxiety symptoms in patients with bipolar depression: a pooled analysis of results from 2 double-blind, randomized, placebo-controlled studies.

OBJECTIVE To evaluate the efficacy and tolerability of quetiapine monotherapy for anxiety symptoms in patients with bipolar disorder experiencing depression in the BipOLar DEpRession (BOLDER I and II) studies. METHOD A post hoc analysis of anxiety symptoms in 1,051 acutely depressed patients with bipolar I or II disorder (DSM-IV) from 2 double-blind, randomized, placebo-controlled 8-week studies of quetiapine (300 or 600 mg once daily) was conducted. Anxiety symptoms were assessed using Hamilton Anxiety Rating Scale (HARS) total and psychic (items 1-6, 14) and somatic (items 7-13) anxiety subscale scores (mixed-model repeated measure and last-observation-carried-forward analysis of change from baseline at each assessment). The BOLDER I study was conducted between September 2002 and October 2003, and the BOLDER II study was conducted between June 2004 and August 2005. RESULTS Mean baseline HARS total scores were similar across the treatment groups (300 mg/d: 18.9, 600 mg/d and placebo: both 18.6). There was a significantly greater improvement from baseline in mean HARS total scores at the first evaluation (week 1) in both quetiapine groups compared with placebo (300 mg/d: -4.6, P < .001 and 600 mg/d: -4.1, P = .003 vs placebo: -2.8). These improvements were sustained through week 8 with both quetiapine doses (300 mg/d: -10.1, P < .001 and 600 mg/d: -10.5, P < .001 vs placebo: -6.9). At week 8, there was also significant improvement from baseline in HARS psychic and somatic anxiety subscale scores compared with placebo (P < .001). The baseline severity of anxiety did not impact the improvement in depressive symptoms. Common adverse events included dry mouth, sedation, somnolence, and dizziness. CONCLUSIONS In this pooled analysis, quetiapine monotherapy was more effective than placebo and generally well tolerated for the treatment of both depressive and anxiety symptoms in patients with bipolar disorder. TRIAL REGISTRATION clinicaltrials.gov Identifiers: NCT00060489 (BOLDER I) and NCT00083954 (BOLDER II).
Ensemble of naı̈ve Bayesian approaches for the study of biofilm development in water distribution systems

The survival and regrowth of microorganisms in drinking water distribution systems (DWDSs) can be affected not only by biological aspects but also by the interaction of various other factors. Some of these factors have been found to be clearly related to biofilm development in DWDSs. However, the complexity of the microenvironment under study and the biofilm growth characteristics have so far led the various methodologies applied to produce ambiguous or not easily comparable, and thus not very useful, results. In this study we compile the information currently available on biofilm ecology in DWDSs and apply various machine learning algorithms based on naı̈ve Bayesian networks. In addition, as a step forward, we also use ensemble methods. These methods have been widely adopted to improve the robustness and the overall prediction accuracy of single models through their accumulative experience on the performance of multiple applications in learning systems. We claim that they also reduce the high uncertainty associated with the process of biofilm development in DWDSs. Specifically, we propose alternatives for the base naı̈ve Bayesian model to outperform its individual results while maintaining its simplicity. These alternatives include augmentation of the arcs in the graph and bagging initial approaches. Then, both ideas are combined by a hybrid algorithm that produces explanatory decision trees. As a result, it is possible to achieve a deeper understanding of the consequences that the interaction of the relevant hydraulic and physical factors of DWDSs has for biofilm development.
Genetic diversity within the genus Trichinella as shown by cleavage fragment length polymorphism analysis

The genetic diversity within the genus Trichinella was studied using cleavage fragment length polymorphism (CFLP) analysis. The CFLP method generates specific fingerprints based on single nucleotide mutations. By this method the amplified intergenic regions of the 5S rRNA genes of the eight different genotypes of Trichinella were analysed. The CFLP pattern of T. spiralis was completely different compared with the sylvatic species T. britovi, T. nativa, T. nelsoni, and the genotypes Trichinella T5, Trichinella T6 and Trichinella T8. The T. pseudospiralis intergenic region can be differentiated by size from the other species of Trichinella.
Arabic Stemmer for Search Engines Information Retrieval

Arabic language is very different and difficult structure than other languages, that’s because it is a very rich language with complex morphology. Many stemmers have been developed for Arabic language but still there are many weakness and problems. There is still lack of usage of Arabic stemming in search engines. This paper introduces a rooted word Arabic stemmer technique. The results of the introduced technique for six Arabic sentences are used in famous search engines Google Chrome, Internet Explore and Mozilla Firefox to check the effect of using Arabic stemming in these search engines in terms of the total number of searched pages and the search time ratio for actual sentences and their stemming results. The results show that Arabic words stemming increase and accelerate the search engines output. Keywords—Information Retrieval; Arabic Stemming; Search Engine; Arabic Morphology
Analysis of a microsatellite polymorphism of the cytotoxic T‐lymphocyte antigen‐4 gene in patients with vitiligo

The CTLA‐4 gene encodes a T‐cell receptor that is involved in the regulation of T‐cell activation. Recent studies have demonstrated an association of a microsatellite polymorphism [variant lengths of a dinucleotide (AT)n repeat] lying in exon 3 of the CTLA‐4 gene, specifically a 106‐bp allele, with autoimmune disorders, such as Graves' disease, autoimmune Addison's disease and autoimmune hypothyroidism. The aim of the present study was to determine whether the same polymorphism of the CTLA‐4 gene was associated with vitiligo, a disorder that may have an autoimmune origin and can be present in patients who have one or more autoimmune diseases. CTLA‐4 gene microsatellite polymorphisms were determined for 74 vitiligo patients (53 without any autoimmune disorder; 21 with one or more autoimmune disease) and 173 healthy controls, who had no clinical evidence of either vitiligo or any other autoimmune disorder, by polymerase chain reaction amplification of genomic DNA and resolution of the products on polyacrylamide sequencing gels. The frequency of the 106‐bp allele was significantly increased (χ2 = 5.2; P = 0.02) in vitiligo patients as a whole, in comparison with control subjects. However, when the patients were classified according to the absence or presence of an autoimmune disorder, the frequency of the 106‐bp allele was significantly increased (χ2 = 14.8; P = 0.0001) only in the group of vitiligo patients who also had an autoimmune disease. However, the fact that 17 of 21 patients also had either autoimmune thyroiditis or autoimmune Addison's disease probably accounts for the apparent association of vitiligo and the 106‐bp allele in this patient group. However, it was found that the relative risk of 3.2, conferred by the 106‐bp allele in this group of vitiligo patients, was greater than that found for patients with only either Graves' disease, autoimmune hypothyroidism or autoimmune Addison's disease, with values of 2.1, 2.2 and 2.2, respectively. For the group of patients without an autoimmune disorder, there was no significant difference (χ2 = 0.2; P = 0.64) in the frequency of the 106‐bp allele when compared with control subjects. These results indicate that there is no association between the 106‐bp allele and vitiligo, at least when the disorder occurs in the absence of an autoimmune disease.
Finding People in Internet Images

In this paper we propose a new contour based approach for people detection in internet images. This approach relies on a large part on perceptual organization principles, at either low level edge detection and higher geometrical level. Our method is mainly compounded of two stages designed to work together\,: a first stage of contour detection, then a second stage of geometrical analysis. We will first describe our new low level perceptually edge detector and we will show its ability of finding robust edges in many types of images. We will then examine the higher level of geometrical processing that we have designed to find bodies among edges extracted by the first stage. We will show results obtained on an image database and images taken over internet.
FDD and FTC for ramp-type actuator fault using intelligent-output-estimator

In this paper, Fault Detection and Diagnosis (FDD) and Active Fault Tolerant Control (AFTC) algorithms are proposed to compensate for a ramp-type Loss-of-Effectiveness (LoE) actuator fault applied on the quadrotor system. Based on the Model-Free concept, an output estimator design called intelligent Output-Estimator (iOE) is presented to estimate the outputs of the system and then used to improve the estimation of the actuator faults. Then the estimation is used to detect and isolate the faulty actuator by generating fault symptoms. Finally, the estimation value is integrated into the control law to compensate for the variable actuator fault. Real-flight results validated the proposed algorithm and showed the actuator fault accommodation process.
Saturated Resin Ectopic Regeneration by Non-Thermal Dielectric Barrier Discharge Plasma

Textile dyes are some of the most refractory organic compounds in the environment due to their complex and various structure. An integrated resin adsorption/Dielectric Barrier Discharge (DBD) plasma regeneration was proposed to treat the indigo carmine solution. It is the first time to report ectopic regeneration of the saturated resins by non-thermal Dielectric Barrier Discharge. The adsorption/desorption efficiency, surface functional groups, structural properties, regeneration efficiency, and the intermediate products between gas and liquid phase before and after treatment were investigated. The results showed that DBD plasma could maintain the efficient adsorption performance of resins while degrading the indigo carmine adsorbed by resins. The degradation rate of indigo carmine reached 88% and the regeneration efficiency (RE) can be maintained above 85% after multi-successive regeneration cycles. The indigo carmine contaminants were decomposed by a variety of reactive radicals leading to fracture of exocyclic C=C bond, which could cause decoloration of dye solution. Based on above results, a possible degradation pathway for the indigo carmine by resin adsorption/DBD plasma treatment was proposed.
Effects of phthalic anhydride modification on horseradish peroxidase stability and activity.

Phthalic anhydride (PA) modification stabilizes horseradish peroxidase (HRP) by reversal of the positive charge on two of HRP's six lysine residues. Native and PA-HRP had half-inactivation temperatures of 51 and 65 degrees C and half-lives at 65 degrees C of 4 and 17 min, respectively. PA-HRP was more resistant to dimethylformamide at room temperature and tetrahydrofuran at 60 degrees C and to unfolding by heat, guanidine chloride, EDTA, and the reducing agent tris(2-carboxyethyl)phosphine hydrochloride. Binding of the hydrophobic probe Nile Red to the native enzyme and to PA-HRP was similar. The kinetics of both HRPs with the substrates ABTS, ferrocyanide, ferulic acid, and indole-3-propionic acid were measured, as was binding of the inhibitor benzhydroxamic acid. Small improvements in the catalytic properties were detected.
Regression Model to Analyse Air Pollutants Over a Coastal Industrial Station Visakhapatnam ( India )

India being one of the fast developing countries ha been experiencing huge population growth as well as rapid urbanization and industrialization le ading to increase in vehicular emissions. These changes significantly affect atmospheric environmen t which leads to impurement of particulate matter [1] – [4]. Correia et al., 2013 [5] reported the affect of particulate matter on global climate , health of mankind as well as visibility. At the sam e time the report of Padoan et al., 2016 [6] was of significance which stated that PM 10 (particulate matter having diameter <10 μm) is responsible for injecting chemicals of harmful nature into the resp iratory system of human beings. This increases diseases related to heart, blood vessels as well as human respiratory system. As per the report of Lim et al., 2012 [7] death count of people due to a ir pollution in 2010 was 3.2 millions. In view of the severity, Central Pollution Control Board (CPCB ) has fixed a 24 hour limit of 100 μg/m and yearly limit of 60 μg/m for PM10 all over India. Even then, increase in unavoidable industrial and vehicular emissions increase the levels of PM 10 concentrations beyond the limits specified by CPCB in majority of the cities [8] – [10]. Delhi is one of the examples which recently experienced AR TIC LE INFO ABSTRACT
Predictions of Freeway Traffic Speeds and Volumes Using Vector Autoregressive Models

Short-term traffic prediction on freeways is one of the critical components of advanced traveler information systems. The traditional methods of prediction have used univariate Auto-Regressive Integrated Moving Average (ARIMA) time series models, based on the autocorrelation function of the time series of traffic variable at a location; however, the effect of upstream and downstream location information has been largely neglected or underutilized in the case of freeway traffic prediction. It is the purpose of this article to demonstrate the effect of upstream as well as downstream locations on the traffic at a specific location. To achieve this, a section of five stations extending over 2.5 miles on I-4 in the downtown region of Orlando, Florida is selected. The speeds from a station at the center of this location are then checked for crosscorrelations with stations upstream and downstream. Cross correlation function is analogous to autocorrelation function extended to two variables. It indicates whether the past values of an input series influence the future values of a response series. It was found that the past values of upstream as well as downstream stations influence the future values at a station and, therefore, can be used for prediction. A vector auto regressive model was found appropriate and better than the traditional ARIMA model for prediction at these stations.
Cell Cycle Analysis of Budding Yeast Using SYTOX Green

Flow cytometric determination of DNA content is a standard tool for cell cycle analysis in the budding yeast, Saccharomyces cerevisiae. Using SYTOX Green instead of propidium iodide (PI) in a standard ethanol fixation protocol increases the accuracy and reproducibility of cell cycle analyses. SYTOX‐stained cells exhibit improved coefficients of variation (CVs), a better correlation between DNA content and fluorescence, and decreased sensitivity to variances in experimental conditions when compared with PI‐stained cells. The SYTOX Green protocol provides researchers with a more accurate and reliable alternative to standard PI‐based protocols for the analysis of the budding yeast cell cycle.
Distributed Generation Using Indirect Matrix Converter in Reverse Power Mode

Indirect matrix converter (IMC) is an alternative for ac/ac energy conversion, usually operated with a voltage stepped-down gain of only 0.866. For applications like distribution generation where voltage-boost functionality is required, the traditional style of operating the IMC is therefore not appropriate. Like most power converters, the operation of the IMC can surely be reversed to produce a boosted gain, but so far its relevant control principles have not been discussed. These challenges are now addressed in this paper with distributed generation suggested as a potential application. Simulation and experimental results for validating various performance aspects of the proposed control schemes can be found in a later section of this paper.
Kinetic measurements of shock wave propagation in a three-dimensional complex (dusty) plasma.

"Complex plasmas" consist of electrons, ions, and charged microparticles. The latter are individually observable, allowing kinetic measurements in plasmas. Using a sudden gas pulse, a traveling perturbation was initiated in such a complex plasma and its propagation, acceleration, and steepening-possibly into a shock was followed. The experiment was performed in the PKE-Nefedov laboratory under microgravity conditions on the international space station, i.e., in a complex plasma cloud with very little stored (potential or free) energy and thus free of, e.g., parametric instabilities. The perturbation front remained remarkably smooth, with a microroughness of the order of the interparticle distance. The observations are presented and interpreted.
Activity profiling of platelets by chemical proteomics

Chemical proteomics or activity based proteomics is a functional proteomics technology where molecular probes are used to target a selective group of functionally related proteins. Its emergence has enabled specific targeting of subproteomes, overcoming the limitations in dynamic range of traditional large‐scale proteomics experiments. Using a chemical proteomics strategy, we attempt to differentially profile the nucleotide‐binding proteome of active and resting platelets. We apply an affinity chromatography protocol using immobilized adenosine triphosphate, cyclic adenosine monophosphate, and cyclic guanosine monophosphate. The specificity of the immobilized nucleotides was demonstrated by competitive assays and by immunoblotting. LC coupled MS/MS was applied to identify the proteins recovered by our chemical proteomics strategy. When compared to a standard set of platelet lysate proteins, we confirmed that enrichment for nucleotide‐binding proteins was indeed taking place. Finally, by employing label‐free MS‐based comparative quantification, we found a small number of platelet proteins that show statistically significant difference between the active and resting nucleotide‐binding proteome.
Nonionic block polymer surfactants modulate the humoral immune response against Streptococcus pneumoniae-derived hexasaccharide-protein conjugates

Nonionic block polymer surfactants (NBPs) were tested for the capacity to stimulate the antibody response against hexasaccharide (HS), derived from Streptococcus pneumoniae type 3 capsular polysaccharide (S3PS), which was conjugated to proteins. The immune response was evaluated in the (CBA/N x BALB/c)F1 progeny, in which female mice are phenotypically normal whereas male mice carry an X-chromosome-linked immunodeficiency. NBPs L101, L121, 1101, and 1501 were able to increase anti-HS immunoglobulin M (IgM) and IgG levels in both normal and X-chromosome-linked immunodeficient mice (with up to 74-fold stimulation of antibody titers). Distribution of S3PS-specific antibodies over the various IgG isotypes was restricted after immunization with either HS-bovine serum albumin or HS-keyhole limpet hemocyanin (HS-KLH). Addition of NBPs (in particular 1501) resulted in a more diverse immune response with either antigen as judged by isotype distribution. Isoelectric focusing of individual sera and subsequent detection of S3PS-binding antibodies in these sera by immunochemical staining revealed a restricted number of different spectrotypes in the course of the immune response. Upon immunization of mice with HS-KLH, spectra of secreted antibodies were slightly more complex and more densely stained than after immunization with HS-bovine serum albumin. Furthermore, NBPs 1101 and 1501 appeared to be able to stimulate the secretion of antibodies, which were secreted only in small amounts without the use of NBPs. Different explanations for increased spectrotype diversity after immunization with KLH as the carrier and after administration of NBPs as the adjuvant are discussed.
Quantitative force versus distance measurements in amplitude modulation AFM: a novel force inversion technique

A new method for extracting quantitative data from amplitude modulation dynamic force–distance measurements is developed. The method is based on the harmonic oscillator model of vibrating atomic force microscope cantilevers, and is capable of extracting both the conservative and dissipative parts of the tip–sample interaction from a measurement of oscillation amplitude and phase as a function of distance. Numerical simulations are used to demonstrate the validity of the method. Further proof of the accuracy of this method is provided by a measurement of electrostatic forces between an AFM tip and a graphite sample.