Miracle-dz/UniFAR-FTUs huggingface dataset:
Atomic Scale Simulation on the Fracture Mechanism of Black Phosphorus Monolayer under Indentation

Molecular dynamics simulations on the indentation process of freestanding and Pt(111)-supported black phosphorus (BP) monolayer were conducted to study the fracture mechanism of the membrane. For the freestanding BP monolayer, crack grows firstly along armchair direction and then zigzag direction during the indentation process. Whereas, for the Pt(111)-supported BP monolayer, crack growth shows no obvious directionality, with irregular distribution of crack tips. Further study on stress distribution shows that maximum normal stress component at elastic stage is in zigzag direction for the freestanding BP monolayer, and in vertical direction for the Pt(111)-supported BP monolayer. As BP monolayer is remarkably anisotropic for in-plane mechanical properties and homogeneous for out-of-plane mechanical properties, the difference of stress state may be a key reason for the different fracture behavior in these two cases. These findings may help to understand the failure mechanism of BP, when applied in nano-devices.
The Pediatric Personal Care Allocation Model for Home Care (PCAM): A Personal Care Case-Mix Model for Children Facing Special Health Care Challenges

Background: State Medicaid programs in the United States provide services to children with special health care challenges through the Early Prevention, Screening, Diagnostic, and Treatment program. One element of the services provided is Medicaid Personal Care Services (PCS), which are intended to correct or ameliorate any functional impairments faced by a child or youth (C/Y) in the community. Previous research indicates that considerable variation in the allocation of PCS depends on the assessor. A case-mix model is developed that might make the distribution of such services more uniform and equitable. Data: The sample in this research includes 2708 C/Y aged 4 to 20 who were receiving PCS in Texas in 2008. Results: A case-mix model was developed that groups sample members into 33 categories based on the number of hours of PCS authorized by an assessor. The Pediatric Personal Care Allocation Model (PCAM) explains 27% of the variance in the allocation of PCS hours. Discussion: The implementation of the PCAM should provide guidance to assist in ensuring that C/Y facing similar functional challenges receive similar levels of PCS. However, implementation of any case-mix model is only a first step in moving to a prospective payment system for PCS.
Acute changes in cardiac function by direct acting antiviral therapy for hepatitis C−infected patients with thalassemia

Patients with thalassemia may also have cardiac abnormalities due to congenital problems, anemia, and increased burden of iron in their myocardium. This study was designed to evaluate the effects of direct acting antiviral (DAA) therapy on the cardiac function of hepatitis C virus (HCV)–infected patients with thalassemia.
Milk osteopontin promotes brain development by up‐regulating osteopontin in the brain in early life

Osteopontin (OPN) is a pleiotropic protein and is abundantly present in milk. Its functions include immune modulation and cellular proliferation and differentiation. OPN is highly expressed in the brain. We investigated the effects of milk‐derived OPN on brain development of mouse pups. Wild‐type (WT) dams producing OPN+ milk and OPN knockout (KO) dams producing OPN− milk nursed WT pups (OPN+/+), yielding 2 pup treatment groups, OPN+ OPN+/+ and OPN− OPN+/+, for comparison. Preliminary studies supported use of this model by showing high concentrations of OPN in milk of WT dams and no OPN in milk of OPN KO dams, and production of similar amounts of milk by WT and KO dams. The ability of ingested milk OPN to enter the brain was revealed by appearance of orally gavaged [125I]‐labeled and antibody‐probed milk OPN in brains of pups. Brain OPN mRNA levels were similar in both nursed groups, but the brain OPN protein level was significantly lower in the OPN− OPN+/+ group at postnatal days 6 and 8. Behavior tests showed impaired memory and learning ability in OPN− OPN+/+ pups. In addition, our study revealed increased expression of myelination‐related proteins and elevated proliferation and differentiation of NG‐2 glia into oligodendrocytes in the brain of OPN+ OPN+/+ pups, accompanied by increased activation of ERK‐1/2 and PI3K7Akt signaling. We concluded that milk OPN can play an important role in brain development and behavior in infancy by promoting myelination. —Jiang, R. , Prell, C. , Lönnerdal, B. Milk osteopontin promotes brain development by up‐regulating osteopontin in the brain in early life. FASEB J. 33, 1681–1694 (2019). www.fasebj. org
Photobiomodulation therapy improves multilineage differentiation of dental pulp stem cells in three-dimensional culture model

Abstract. Photobiomodulation therapy (PBM) has shown positive effects on stem cell differentiation in monolayer cell culture model, but little is known about its effect on three-dimensional (3-D) agarose gel culture. This study evaluated the PBM effect of human dental pulp stem cells (hDPSCs) differentiation and phosphatase alkaline activity (ALP) using an agarose 3-D model under different nutritional conditions. hDPSCs were characterized and seeded on a 0.3% agarose gel layer with different media (osteogenic, adipogenic, chondrogenic) and were assigned into four groups: control 10% fetal bovine serum (FBS), control 5% FBS, PBM 10% FBS, and PBM 5% FBS. Irradiation was performed with continuous-wave InGaAlP laser, 660 nm, 100 mW, 3,3 J / cm2, spot size 0.3 cm2, 10 s of exposure time, and 1 J of energy per point with 6-h interval between sessions. All groups were evaluated at 7 and 14 days. ALP assay was performed to analyze the deposition of mineralized tissue. At 7 days, PBM 5% FBS group presented better stimulation in osteogenic and adipogenic differentiation compared with control. After 14 days, hDPSCs cultured in 3-D exhibited osteogenic, adipogenic, and chondrogenic differentiation; furthermore, compared to control, PBM significantly stimulated all differentiation processes (p < 0.05). It can be concluded that hDPSCs cultured in 3-D agarose associated to PBM could be a promising tool for tissue engineering applications.
First Aid Practices and Health-Seeking Behaviors of Caregivers for Unintentional Childhood Injuries in Ujjain, India: A Community-Based Cross-Sectional Study

Data on types of community first aid use and treatment provided post-injury from many low‒middle-income countries, including India, are lacking. This cross-sectional study was conducted among children aged one month to 18 years of age, in Ujjain, India, to understand types of first aid given and health-seeking post-injury. A total of 1087 injuries in 1049 children were identified in the past year. A total of 729 (67%) injured children received first aid and 758 (70%) sought some form of health care. Children with burns received the most (86%) first aid, and most children (84%) with road traffic accidents (RTA) sought health care. Most children (52%) sought health care from a private health care facility; most children (65%) were transported to a health care facility within the golden hour. Motorbikes were the most preferred (50%) mode of transport. Only 1% of the injured used ambulance services. Commonly reported methods or substances for first aid included the use of coconut oil on wounds from falls (38%) and burns (44%), the use of antiseptic cream on wounds from RTA (31%), the application of turmeric for wounds from falls (16%), and rubbing of metal on a bitten area (47%). For most injuries, appropriate, locally available substances were used. Potentially harmful substances applied included lime, toothpaste, clay, and mud. The findings will help design community interventions to increase the provision of appropriate first aid for childhood injuries.
Berberine Ameliorates Periodontal Bone Loss by Regulating Gut Microbiota

Postmenopausal osteoporosis (PMO) is a risk factor for periodontitis, and current therapeutics against PMO prevent the aggravated alveolar bone loss of periodontitis in estrogen-deficient women. Gut microbiota is recognized as a promising therapeutic target for PMO. Berberine extracted from Chinese medicinal plants has shown its effectiveness in the treatment of metabolic diseases such as obesity and diabetes via regulating gut microbiota. Here, we hypothesize that berberine ameliorates periodontal bone loss by improving the intestinal barriers by regulating gut microbiota under an estrogen-deficient condition. Experimental periodontitis was established in ovariectomized (OVX) rats, and the OVX-periodontitis rats were treated with berberine for 7 wk before sacrifice for analyses. Micro–computed tomography and histologic analyses showed that berberine treatment significantly reduced alveolar bone loss and improved bone metabolism of OVX-periodontitis rats as compared with the vehicle-treated OVX-periodontitis rats. In parallel, berberine-treated OVX-periodontitis rats harbored a higher abundance of butyrate-producing gut microbiota with elevated butyrate generation, as demonstrated by 16S rRNA sequencing and high-performance liquid chromatography analysis. Berberine-treated OVX-periodontitis rats consistently showed improved intestinal barrier integrity and decreased intestinal paracellular permeability with a lower level of serum endotoxin. In parallel, IL-17A-related immune responses were attenuated in berberine-treated OVX-periodontitis rats with a lower serum level of proinflammatory cytokines and reduced IL-17A+ cells in alveolar bone as compared with vehicle-treated OVX-periodontitis rats. Our data indicate that gut microbiota is a potential target for the treatment of estrogen deficiency–aggravated periodontal bone loss, and berberine represents a promising adjuvant therapeutic by modulating gut microbiota.
Captaina: Integrated Pronunciation Practice and Data Collection Portal

We demonstrate Captaina, computer assisted pronunciation training portal. It is aimed at university students, who read passages aloud and receive automatic feedback based on speech recognition and phoneme classiﬁcation. Later their teacher can provide more accurate feedback and comments through the portal. The system enables better independent practice. It also acts as a data collection method. We aim to gather both good quality second language speech data with segmentations, and the teacher given evaluations of pronunciation
Neurometabolic indicators of mitochondrial dysfunction in repetitive mild traumatic brain injury

Mild traumatic brain injury (mTBI) is a significant national health concern and there is growing evidence that repetitive mTBI (rmTBI) can cause long-term change in brain structure and function. The mitochondrion has been suggested to be involved in the mechanism of TBI. There are noninvasive methods of determining mitochondrial dysfunction through biomarkers and spectroscopy. Mitochondrial dysfunction has been implicated in a variety of neurological consequences secondary to rmTBI through activation of caspases and calpains. The purpose of this review is to examine the mechanism of mitochondrial dysfunction in rmTBI and its downstream effects on neuronal cell death, axonal injury and blood–brain barrier compromise.
Development of a Social Network for Research Support and Individual Well-Being Improvement

The ways of communication and social interactions are changing drastically. Web users are becoming increasingly engaged with Online Social Networks (OSN), which has a significant impact on the relationship mechanisms between individuals and communities. Most OSN platforms have strict policies regarding data access, harming its usage in psychological and social phenomena studies; It is also impacting the development of computational methods to evaluate and improve social and individual well-being via the web. Aiming to fill this gap, we propose in this paper a platform that brings together social networks dynamics with forum features, altogether with gamification elements, targeting researchers interested in obtaining access to user's data their investigations.
Comparison of ego strength between aggressive and non-aggressive alcoholics: a cross-sectional study

Aim To determine the differences between aggressive and non-aggressive alcoholics in sociodemographic and clinical characteristics and ego strength. Methods This cross-sectional study included 111 aggressive and 123 non-aggressive male alcoholics aged between 25 and 60 years who were admitted to the Department for Alcoholism, University Psychiatric Hospital Vrapče, Zagreb, Croatia, from January to December 2016. All participants met the diagnostic criteria for alcohol dependence according to the Croatian Mini International Neuropsychiatric Interview (MINI), 4th revised edition of Diagnostic and Statistical Manual of Mental Disorders, and the International Classification of Diseases. Participants were clinically assessed by an experienced psychiatrist using a clinical interview, MINI, Questionnaire from the Brown-Goodwin Lifetime History of Aggression, and Ego Identity Scale (EIS) according to Erikson. A clinical psychologist performed cognitive function measurements. EIS scores were analyzed using one-way analysis of variance. Results In comparison with non-aggressive alcoholics, aggressive alcoholics were more often divorced, unemployed, hospitalized, and first treated for alcoholism at an earlier age (P < 0.05 for all). They more frequently experienced depression (42.4% vs 19.4%, P = 0.013) and attempted suicide (34.7% vs 6.2%, P = 0.003), achieved a lower level of maturity at the second stage of psychosocial development related to shame and doubt (14.0 ± 4.1 vs 17.4 ± 3.7, P = 0.013) and at the fourth stage related to inferiority (13.1 ± 6.8 vs 18.1 ± 9.3, P = 0.011), and had lower total EIS score (75.8 ± 20.4 vs 85.2 ± 21.5, P < 0.012) than non-aggressive alcoholics. Conclusion Aggressive alcoholics had weaker ego-strength than non-aggressive alcoholics, experienced more depressive reactions and suicide attempts, and showed poorer psychosocial functioning. Oxford Centre for Evidence-based Medicine level of evidence: 3**
The JastAdd extensible Java compiler

JastAddJ is a Java compiler that is easy to extend with new analyses and language constructs. The main systems contains a Java 1.4 compiler with modular Java5 extensions. It compares favourably in quality and size compared to other Java compilers, and runs within a factor of three compared to javac.
2. News waves in a changing media landscape 1950-2014

Over time the number of news waves seem to be increasing. Due to intensif ied competition, journalists are increasingly responding to stories in other media and audience preferences, at the expense of stories on political issues. By using the digitalized archive of the Dutch newspaper De Telegraaf, news waves were automatically identif ied in the four million articles from 1950-2014. Contrary to expectations, the amount of news waves has not increased linearly since the 1950s, but shows a U-curve, with more waves in the 1950s than in the 1970s. Political content in news waves peaked in the 1990s. The general shape of news waves consists of a small lead, a sharp and narrow peak, and a slow decline.
Weakly Supervised POS Tagging without Disambiguation

Weakly supervised part-of-speech (POS) tagging is to learn to predict the POS tag for a given word in context by making use of partial annotated data instead of the fully tagged corpora. Weakly supervised POS tagging would benefit various natural language processing applications in such languages where tagged corpora are mostly unavailable. In this article, we propose a novel framework for weakly supervised POS tagging based on a dictionary of words with their possible POS tags. In the constrained error-correcting output codes (ECOC)-based approach, a unique L-bit vector is assigned to each POS tag. The set of bitvectors is referred to as a coding matrix with value { 1, -1}. Each column of the coding matrix specifies a dichotomy over the tag space to learn a binary classifier. For each binary classifier, its training data is generated in the following way: each pair of words and its possible POS tags are considered as a positive training example only if the whole set of its possible tags falls into the positive dichotomy specified by the column coding and similarly for negative training examples. Given a word in context, its POS tag is predicted by concatenating the predictive outputs of the L binary classifiers and choosing the tag with the closest distance according to some measure. By incorporating the ECOC strategy, the set of all possible tags for each word is treated as an entirety without the need of performing disambiguation. Moreover, instead of manual feature engineering employed in most previous POS tagging approaches, features for training and testing in the proposed framework are automatically generated using neural language modeling. The proposed framework has been evaluated on three corpora for English, Italian, and Malagasy POS tagging, achieving accuracies of 93.21%, 90.9%, and 84.5% individually, which shows a significant improvement compared to the state-of-the-art approaches.
Preparation of Quasi-Three-Dimensional Porous Ag and Ag-NiO Nanofibrous Mats for SERS Application

In this study, two new quasi-three-dimensional Surface Enhanced Raman Scattering (SERS) substrates, namely porous Ag and Ag-NiO nanofibrous mats, were prepared using a simple, electrospinning-calcination, two-step synthetic process. AgNO3/polyvinyl pyrrolidone (PVP) and AgNO3/Ni(NO3)2/PVP composites serving as precursors were electrospun to form corresponding precursory nanofibers. Porous Ag and Ag-NiO nanofibers were successfully obtained after a 3-h calcination at 500 °C under air atmosphere, and analyzed using various material characterization techniques. Synthesized, quasi-three-dimensional porous Ag and Ag-NiO nanofibrous mats were applied as SERS substrates, to measure the model compound Rhodamine 6G (R6G), and investigate the corresponding signal enhancement. Furthermore, porous Ag and Ag-NiO nanofibrous mats were employed as SERS substrates for melamine and methyl parathion respectively. Sensitive detection of melamine and methyl parathion was achieved, indicating their feasibility as an active SERS sensing platform, and potential for food safety and environmental monitoring. All the results suggest that the electrospinning-calcination, two-step method offers a new, low cost, high performance solution in the preparation of SERS substrates.
Housing Decisions Among Homeless Families Involved in the Child Welfare System

Abstract The present study embedded a qualitative substudy within a randomized controlled trial of housing services for child welfare-involved families to examine housing decisions made in the face of homelessness and child protection. Participants included a representative sample of caregivers (n = 19) randomized to receive the Family Unification Program—a permanent housing intervention for inadequately housed families under investigation for child abuse or neglect—or child welfare services as usual. Qualitative interviews 12 months after randomization assessed housing decision-making processes involved in keeping families safe and stable. Results indicated a push–pull dynamic that constrained housing choices regardless of whether permanent housing was made available. Caregiver housing decisions were constrained by time limitations, affordability, and access to services, whereas child and family safety was perceived as less important. Findings emphasize the need for housing-informed child welfare services to ensure the long-term safety of children in families experiencing homelessness.
Development of the urostyle during metamorphosis in five species of anurans

Normal development of the urostyle is described during late stages of metamorphosis in five species of anurans: Xenopus laevis (Daudin), Bufo americanus Holbrook, Pseudacris triseriata (Wied), Hyla chrysoscelis Cope, and Rana pipiens Schreber. The developing urostyle of all five species is composed of essentially the same cartilaginous elements: one pair of basidorsals above the notochord and the subtended hypochord. Among the five species there is variation in such details as the number of spinal nerve foramina and the degree of fusion of the basidorsals; however, both the hypochord and basidorsals are very similar in all five genera examined. Consideration of the literature suggests that contradictory descriptions of the developing urostyle result from (1) varied methods of study (alizarin‐staining of whole specimens or serial cross‐sections), (2) the variety of species examined, and (3) the particular stage of development of the tadpole described by an investigator.
Anomaly Detection and Explanation Discovery on Event Streams

As enterprise information systems are collecting event streams from various sources, the ability of a system to automatically detect anomalous events and further provide human readable explanations is of paramount importance. In this position paper, we argue for the need of a new type of data stream analytics that can address anomaly detection and explanation discovery in a single, integrated system, which not only offers increased business intelligence, but also opens up opportunities for improved solutions. In particular, we propose a two-pass approach to building such a system, highlight the challenges, and offer initial directions for solutions.
Augmentation of Pharmacotherapy by Sleep Deprivation with Sleep Phase Advance in Treatment-Resistant Depression

Abstract Introduction The aim was to assess the efficacy of total sleep deprivation (TSD) with sleep phase advance (SPA) in treatment-resistant depression (TRD) and associated biochemical factors. Methods We studied nine males and 12 females, aged 49±14 years, with treatment-resistant unipolar or bipolar depression, receiving antidepressant and mood-stabilizing drugs. The four-day schedule included single TSD and three consecutive nights with SPA. Biochemical markers were measured on the day before and on 1st, 7th and 14th day after the TSD. Results Ten subjects met criteria for response, defined as a reduction of ≥50% in the Hamilton Depression Rating Scale, on the 14th day. Concentrations of cortisol at baseline were lower in responders, and they decreased during therapy in both groups. In responders, there was an increase of interleukin-10 (IL-10) and IL-1β on the 14th day. Discussion Our preliminary study demonstrated the efficacy of pharmacotherapy augmentation by TSD and SPA in half of the patients with TRD. The main biochemical factors related to clinical response included status of cortisol and increase in IL-10 and IL-1β levels.
Game-based Spoken Dialog Language Learning Applications for Young Students

This demo presents three different spoken dialog applications that were developed to provide young learners of English an opportunity to practice speaking and to receive feedback on particular aspects of their English speaking ability. The speaking tasks were designed as game-based interactions in order to engage young students, and they provide feedback about grammar ( yes/no question formation and simple past tense verb formation) and vocabulary. A pilot study with 27 primary-level English as a foreign language (EFL) learners investigated the usefulness of these applications.