Miracle-dz/UniFAR-FTUs huggingface dataset:
Research on Visualization and Error Compensation of Demolition Robot Attachment Changing

Attachment changing in demolition robots has a high docking accuracy requirement, so it is hard for operators to control this process remotely through the perspective of a camera. To solve this problem, this study investigated positioning error and proposed a method of error compensation to achieve a highly precise attachment changing process. This study established a link parameter model for the demolition robot, measured the error in the attachment changing, introduced a reference coordinate system to solve the coordinate transformation from the dock spot of the robot’s quick-hitch equipment to the dock spot of the attachment, and realized error compensation. Through calculation and experimentation, it was shown that the error compensation method proposed in this study reduced the level of error in attachment changing from the centimeter to millimeter scale, thereby meeting the accuracy requirements for attachment changing. This method can be applied to the remote-controlled attachment changing process of demolition robots, which provides the basis for the subsequent automatic changing of attachments. This has the potential to be applied in nuclear facility decommissioning and dismantling, as well as other radioactive environments.
Psychosocial Mechanism of Adolescents’ Depression: A Dose-Response Relation with Physical Activity

Depression has become the most prevalent mental health problem in developing countries, and especially among adolescents. Lubans and his colleagues proposed a psychosocial mechanism to understand the trajectory of mental health (i.e., depression). Thus, this study aimed (1) to examine the relations between different doses of physical activity (PA), light PA (LPA), moderate PA (MPA), and vigorous PA (VPA), academic self-efficacy, and depression among adolescents, and (2) to investigate the direct and indirect relations of various doses of PA to depression through academic self-efficacy among middle school adolescents. Participants were 428 (235 boys, Mean age = 13.7) adolescents recruited from two middle schools in China. They completed previously validated questionnaires to measure different intensity levels of PA (LPA, MPA, and VPA), academic self-efficacy, and depression. There were significant associations of academic self-efficacy with three different doses of PA (p < 0.01). Both LPA and MPA were negatively associated with depression but not VPA. Structural equation modeling (SEM) revealed a well-fit model suggesting the psychosocial pathway from different doses of PA to depression through academic self-efficacy. Findings of this study indicated that academic self-efficacy regulates adolescents’ depression. Tailoring different intensities of PA benefits adolescents’ academic self-efficacy by framing the positive and supportive environment in schools, which can potentially reduce the prevalence of depression during adolescence.
The Effects of Human BDH2 on the Cell Cycle, Differentiation, and Apoptosis and Associations with Leukemia Transformation in Myelodysplastic Syndrome

Iron overload is related to leukemia transformation in myelodysplastic syndrome (MDS) patients. Siderophores help to transport iron. Type 2-hydroxybutyrate dehydrogenase (BDH2) is a rate-limiting factor in the biogenesis of siderophores. Using qRT-PCR, we analyze BDH2mRNA expression in the bone marrow (BM) of 187 MDS patients, 119 de novo acute myeloid leukemia (AML) patients, and 43 lymphoma patients with normal BM. Elevated BDH2mRNA expression in BM is observed in MDS patients (n = 187 vs. 43, normal BM; P = 0.009), and this is related to ferritin levels. Patients with higher BDH2 expression show a greater risk of leukemia progression (15.25% vs. 3.77%, lower expression; P = 0.017) and shorter leukemia-free-survival (medium LFS, 9 years vs. 7 years; P = 0.024), as do patients with a ferritin level ≥350 ng/mL. Additionally, we investigate the mechanisms related to the prognostic ability of BDH2 by using BDH2-KD THP1. The cell cycle analysis, surface markers, and special stain studies indicate that BDH2-KD induces differentiation and decreases the growth rate of THP1 cells, which is associated with the retardation of the cell cycle. Moreover, many genes, including genes related to mitochondrial catabolism, oncogenes, tumor suppressor genes, and genes related to cell differentiation and proliferation influence BDH2-KD THP1 cells. Herein, we demonstrate that BDH2 is involved in cell cycle arrest and the inhibition of differentiation in malignant cells. Furthermore, the high BDH2 expression in MDS patients could be suggestive of a poor prognostic factor. This study provides a foundation for further research on the roles of BDH2 and iron metabolism in the pathogenesis of MDS.
Safe Helicopter Landing on Unprepared Terrain Using Onboard Interferometric Radar

This letter proposes a radar interferometric survey system for the ground surface of helicopter landing sites. This system generates high-quality three-dimensional terrain surface topography data and estimates the slope of the site with the required accuracy. This study presents the processing algorithms of the radar system for safe helicopter landing using an interferometric method and also demonstrates the efficiency of the proposed approach based on computer simulation results. The results of the calculated potential accuracy characteristics of such a system are presented, as well as one of the variants of the algorithmic implementation of a simulation computer model implemented on MATLAB. Visual results of modeling using an example of a helicopter landing on a non-uniform surface relief similar to a real case are shown. The study focuses on the simulation of a unique on-board radar system, which allows helicopters to land on an unprepared site with a high degree of safety, having previously determined the presence of dangerous irregularities, inclines, foreign objects, and mechanisms on the site.
Are dual-purpose hens less fearful than conventional layer hybrids?

Background Excessive fear in farm animals can lead to chronic stress and thus impair animal welfare. In laying hens, fear responses in several behavioural tests have also been associated with the occurrence of feather pecking. The aim of the present study was to comparatively assess fear-related responses of conventional layer hybrids (Lohmann Brown plus, LB+) and dual-purpose hens (Lohmann Dual, LD), which seem to be less prone to injurious pecking. Methods A novel object (NO) and an avoidance distance (AD) test were carried out in both hybrids at a group level and at different ages during the laying period in order to measure their fear-related responses. Results On most study days, more LD hens approached the NO and they approached it sooner than the LB+ hens. Similarly, the LD hens retreated at smaller distances from a human being in the AD test. Conclusion The results indicate that dual-purpose hens act less fearful in the performed behavioural tests compared with conventional layer hybrids. Therefore, dual-purpose hens might experience less stress during daily management routines, which would affect animal welfare positively.
Beyond Cyberbullying: Investigating When and How Cybervictimization Predicts Suicidal Ideation

Cybervictimization is a public health concern in adolescence. Victims of cyberbullying may present with important short- and long-term sequelae. Specifically, past research has demonstrated positive associations between being cybervictimized and risk of suicide among adolescents. Nonetheless, the underlying mechanisms that may mediate or moderate this relationship remain unclear. The present research examined perceived stress as a mediator and forgiveness as a moderator to explore the relationship between cybervictimization and suicidal ideation. Specifically, vengeance, avoidance, and benevolence motivations, as a means of measuring forgiveness experienced, were analyzed as moderators in the relations between cybervictimization and suicidal ideation. The sample included 1,821 adolescents (954 girls) who ranged in age from 12 to 17 years from nine centers. Adolescents’ self-reported perceived stress levels, cybervictimization, and forgiveness were collected. A mediation and a moderated mediation analyses were used to explore the aim of the present study. Results suggest that, after controlling for sex and age, perceived stress partially mediates the association between cybervictimization and suicidal ideation. Furthermore, the mediation effects of perceived stress were independently moderated by vengeance and avoidance. Thus, revenge and avoidance might intensify the adverse impact of perceived stress on suicidal ideation. These results highlight how and when cybervictimization is related to suicidal ideation. We discuss the results in relation to previous research and consider their practical implications. These findings suggest that adolescents’ perceived stress, together with vengeance and avoidance motivations, may be key targets for prevention and intervention programs dealing with cybervictimization. This highlights the need to implement treatment and prevention programs focused on decreasing such motivations.
A bacterial riboswitch class senses xanthine and uric acid to regulate genes associated with purine oxidation

Dozens of candidate orphan riboswitch classes have been discovered previously by using comparative sequence analysis algorithms to search bacterial genomic sequence databases. Each orphan is classified by the presence of distinct conserved nucleotide sequences and secondary structure features, and by its association with particular types of genes. One previously reported orphan riboswitch candidate is the “NMT1 motif,” which forms a hairpin structure with an internal bulge that includes numerous highly conserved nucleotides. This motif associates with genes annotated to encode various dioxygenase enzymes, transporters, or proteins that have roles associated with thiamin or histidine metabolism. Biochemical evaluation of numerous ligand candidates revealed that NMT1 motif RNA constructs most tightly bind 8-azaxanthine, xanthine, and uric acid, whereas most other closely related compounds are strongly rejected. Genetic assays revealed that NMT1 motif RNAs function to turn off gene expression upon ligand binding, likely by regulating translation initiation. These results suggest that NMT1 motif RNAs function as aptamer domains for a riboswitch class that specifically responds to high concentrations of oxidized purines. Members of this “xanthine riboswitch” class appear to regulate genes predominantly related to purine transport and oxidation, thus avoiding the effects of overproduction of these common purine derivatives.
Evaluating Lightning‐Caused Fire Occurrence Using Spatial Generalized Additive Models: A Case Study in Central Spain

It is widely accepted that the relationship between lightning wildfire occurrence and its influencing factors vary depending on the spatial scale of analysis, making the development of models at the regional scale advisable. In this study, we analyze the effects of different biophysical variables and lightning characteristics on lightning‐caused forest wildfires in Castilla y León region (Central Spain). The presence/absence of at least one lightning‐caused fire in any 4 × 4‐km grid cell was used as a dependent variable and vegetation type and structure, terrain, climate, and lightning characteristics were used as possible covariates. Five prediction methods were compared: a generalized linear model (GLM), a random forest model (RFM), a generalized additive model (GAM), a GAM that includes a spatial trend function (GAMs) and a spatial autoregressive model (AUREG). A GAMs with just one covariate, apart from longitude and latitude for each observation included as a combined effect, was considered the most appropriate model in terms of both predictive ability and simplicity. According to our results, the probability of a forest being affected by a lightning‐caused fire is positively and nonlinearly associated with the percentage of coniferous woodlands in the landscape, suggesting that occurrence is more closely associated with vegetation type than with topography, climate, or lightning characteristics. The selected GAMs is intended to inform the Regional Government of Castilla y León (the fire and fuel agency in the region) regarding identification of areas at greatest risk so it can design long‐term forest fuel and fire management strategies.
Improved bacterial RNA-seq by Cas9-based depletion of ribosomal RNA reads

A major challenge for RNA-seq analysis of gene expression is to achieve sufficient coverage of informative nonribosomal transcripts. In eukaryotic samples, this is typically achieved by selective oligo(dT)-priming of messenger RNAs to exclude ribosomal RNA (rRNA) during cDNA synthesis. However, this strategy is not compatible with prokaryotes in which functional transcripts are generally not polyadenylated. To overcome this, we adopted DASH (depletion of abundant sequences by hybridization), initially developed for eukaryotic cells, to improve both the sensitivity and depth of bacterial RNA-seq. DASH uses the Cas9 nuclease to remove unwanted cDNA sequences prior to library amplification. We report the design, evaluation, and optimization of DASH experiments for standard bacterial short-read sequencing approaches, including software for automated guide RNA (gRNA) design for Cas9-mediated cleavage in bacterial rDNA sequences. Using these gRNA pools, we effectively removed rRNA reads (56%–86%) in RNA-seq libraries from two different model bacteria, the Gram-negative pathogen Salmonella enterica and the anaerobic gut commensal Bacteroides thetaiotaomicron. DASH works robustly, even with subnanogram amounts of input RNA. Its efficiency, high sensitivity, ease of implementation, and low cost (∼$5 per sample) render DASH an attractive alternative to rRNA removal protocols, in particular for material-constrained studies where conventional ribodepletion techniques fail.
The impact of anthropogenic and environmental factors on human rabies cases in China.

Human rabies is a public health problem in Asia, especially in less developed regions where the disease is under-reported because of a lack of epidemiological surveillance. To address this gap, we collected data on human rabies in Yunnan Province, China, between 2005 and 2016. Using statistical mapping techniques, we correlated the occurrence of human rabies to environmental (elevation, precipitation, normalized difference vegetation index [NDVI], temperature, and distance to the nearest main rivers) and anthropogenic (human and dog population density, distance to the nearest main roads, and gross domestic product [GDP]) factors. We used a performance score, the average area under the receiver operator characteristic curve (0.88), to validate our risk model. Using this model, we found that environmental factors were more strongly associated with human rabies occurrence than anthropogenic factors. Areas with elevation below 2000 meters, GDP per capita between $750-$4500/year, and NDVI below 0.07 were associated with greater risk of human rabies. Rabies control in China should specifically target these areas.
Influence of Anesthesia and Clinical Variables on the Firing Rate, Coefficient of Variation and Multi-Unit Activity of the Subthalamic Nucleus in Patients with Parkinson’s Disease

Background: Microelectrode recordings (MER) are used to optimize lead placement during subthalamic nucleus deep brain stimulation (STN-DBS). To obtain reliable MER, surgery is usually performed while patients are awake. Procedural sedation and analgesia (PSA) is often desirable to improve patient comfort, anxiolysis and pain relief. The effect of these agents on MER are largely unknown. The objective of this study was to determine the effects of commonly used PSA agents, dexmedetomidine, clonidine and remifentanil and patient characteristics on MER during DBS surgery. Methods: Data from 78 patients with Parkinson’s disease (PD) who underwent STN-DBS surgery were retrospectively reviewed. The procedures were performed under local anesthesia or under PSA with dexmedetomidine, clonidine or remifentanil. In total, 4082 sites with multi-unit activity (MUA) and 588 with single units were acquired. Single unit firing rates and coefficient of variation (CV), and MUA total power were compared between patient groups. Results: We observed a significant reduction in MUA, an increase of the CV and a trend for reduced firing rate by dexmedetomidine. The effect of dexmedetomidine was dose-dependent for all measures. Remifentanil had no effect on the firing rate but was associated with a significant increase in CV and a decrease in MUA. Clonidine showed no significant effect on firing rate, CV or MUA. In addition to anesthetic effects, MUA and CV were also influenced by patient-dependent variables. Conclusion: Our results showed that PSA influenced neuronal properties in the STN and the dexmedetomidine (DEX) effect was dose-dependent. In addition, patient-dependent characteristics also influenced MER.
Computer-Aided Design of Microfluidic Circuits.

Microfluidic devices developed over the past decade feature greater intricacy, increased performance requirements, new materials, and innovative fabrication methods. Consequentially, new algorithmic and design approaches have been developed to introduce optimization and computer-aided design to microfluidic circuits: from conceptualization to specification, synthesis, realization, and refinement. The field includes the development of new description languages, optimization methods, benchmarks, and integrated design tools. Here, recent advancements are reviewed in the computer-aided design of flow-, droplet-, and paper-based microfluidics. A case study of the design of resistive microfluidic networks is discussed in detail. The review concludes with perspectives on the future of computer-aided microfluidics design, including the introduction of cloud computing, machine learning, new ideation processes, and hybrid optimization. Expected final online publication date for the Annual Review of Biomedical Engineering, Volume 22 is June 4, 2020. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD

Caspase-1 activation in GSDMD-deficient cells induces a rapid form of caspase-3–dependent secondary necrosis that is licenced by caspase-1–induced Bid cleavage and the release of mitochondrial SMAC. Caspase-1 drives a lytic inflammatory cell death named pyroptosis by cleaving the pore-forming cell death executor gasdermin-D (GSDMD). Gsdmd deficiency, however, only delays cell lysis, indicating that caspase-1 controls alternative cell death pathways. Here, we show that in the absence of GSDMD, caspase-1 activates apoptotic initiator and executioner caspases and triggers a rapid progression into secondary necrosis. GSDMD-independent cell death required direct caspase-1–driven truncation of Bid and generation of caspase-3 p19/p12 by either caspase-8 or caspase-9. tBid-induced mitochondrial outer membrane permeabilization was also required to drive SMAC release and relieve inhibitor of apoptosis protein inhibition of caspase-3, thereby allowing caspase-3 auto-processing to the fully active p17/p12 form. Our data reveal that cell lysis in inflammasome-activated Gsdmd-deficient cells is caused by a synergistic effect of rapid caspase-1–driven activation of initiator caspases-8/-9 and Bid cleavage, resulting in an unusually fast activation of caspase-3 and immediate transition into secondary necrosis. This pathway might be advantageous for the host in counteracting pathogen-induced inhibition of GSDMD but also has implications for the use of GSDMD inhibitors in immune therapies for caspase-1–dependent inflammatory disease.
High-Throughput Computational Search for Half-Metallic Oxides

Half metals are a peculiar class of ferromagnets that have a metallic density of states at the Fermi level in one spin channel and simultaneous semiconducting or insulating properties in the opposite one. Even though they are very desirable for spintronics applications, identification of robust half-metallic materials is by no means an easy task. Because their unusual electronic structures emerge from subtleties in the hybridization of the orbitals, there is no simple rule which permits to select a priori suitable candidate materials. Here, we have conducted a high-throughput computational search for half-metallic compounds. The analysis of calculated electronic properties of thousands of materials from the inorganic crystal structure database allowed us to identify potential half metals. Remarkably, we have found over two-hundred strong half-metallic oxides; several of them have never been reported before. Considering the fact that oxides represent an important class of prospective spintronics materials, we have discussed them in further detail. In particular, they have been classified in different families based on the number of elements, structural formula, and distribution of density of states in the spin channels. We are convinced that such a framework can help to design rules for the exploration of a vaster chemical space and enable the discovery of novel half-metallic oxides with properties on demand.
Rio Doce Acoustic Surveys of Fish Biomass and Aquatic Habitat

Following the failure of the Fundão mine tailings dam in Brazil, approximately 32 million cubic meters of Fe ore tailings were released into the downstream riverine system. The postevent monitoring surveys implemented the use of noninvasive acoustic methods to improve the understanding of the fish biomass distribution patterns and aquatic habitat condition of the impacted reaches of the Rio Gualaxo do Norte, Rio do Carmo, and Rio Doce. The primary focus of the program was to collect hydroacoustic measurements of fish biomass, which was accompanied by sonar imaging of aquatic habitats using high‐resolution side scan and downward imaging sonar at each site visited. The biannual surveys began in April 2017 and were fundamentally a multiple control–impact design because before data (prior to the dam failure event) were not available. Up to 22 sites were visited for each survey, including reservoir and river sites. Results indicate similar levels of instream habitat between control and impact river and reservoir sites. Average volumetric biomass was not significantly different between impact sites and their corresponding controls in the August 2018 survey (latest to date). Preliminary temporal analysis of the biomass data set collected indicates that either stable or increasing levels of biomass are detected at tailings impacted sites within the Rio Doce. Integr Environ Assess Manag 2020;16:615–621. © 2020 Hydrobiology QLD Pty Ltd. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC)