Miracle-dz/UniFAR-FTUs huggingface dataset:
An object detection and tracking system for unmanned surface vehicles

Object detection and tracking are critical parts of unmanned surface vehicles(USV) to achieve automatic obstacle avoidance. Off-the-shelf object detection methods have achieved impressive accuracy in public datasets, though they still meet bottlenecks in practice, such as high time consumption and low detection quality. In this paper, we propose a novel system for USV, which is able to locate the object more accurately while being fast and stable simultaneously. Firstly, we employ Faster R-CNN to acquire several initial raw bounding boxes. Secondly, the image is segmented to a few superpixels. For each initial box, the superpixels inside will be grouped into a whole according to a combination strategy, and a new box is thereafter generated as the circumscribed bounding box of the final superpixel. Thirdly, we utilize KCF to track these objects after several frames, Faster-RCNN is again used to re-detect objects inside tracked boxes to prevent tracking failure as well as remove empty boxes. Finally, we utilize Faster R-CNN to detect objects in the next image, and refine object boxes by repeating the second module of our system. The experimental results demonstrate that our system is fast, robust and accurate, which can be applied to USV in practice.
Effect of Hearing Loss on Quality of Life among Elderly in Zagazig City

Background: Hearing loss is the third most prevalent chronic condition among elderly. Which have a negative impact on their quality of life. Aim of this study: was to assess the effect of hearing loss on quality of life among elderly. Subjects and methods: Research design: A Cross-Sectional descriptive design used in the present study. Setting: The study conducted at the auditory unit in The New Surgery Hospital in Zagazig University. Subjects: on a purposive sample consisted of 200 elderly. Tools for data collection: Four tools were used to collect data: Tool I: A structured interview questionnaire format was developed by the researcher to collect data about demographic characteristics of the studied subjects, medical and hearing history. Tool II: Elderly hearing condition. Tool III: Quality of life of elderly with hearing loss. Tool IV: Hearing aids data. Results: The study revealed that more than two thirds (68.5%) of the studied elderly belonged to the age group 61to less than 71 years, while most of them (72.5%) were illiterate. More than half of the studied elderly (55.5%) had low total quality of life score compared to 39.0% of them had moderate scores. There was statistically significant relation between the studied elderly total quality of life scores and their socio demographic data (p< 0.05). Conclusion: The study concluded that quality of life of elderly with hearing loss was affected especially role activities followed by social then physical functioning. Recommendation: Applying continuous educational programs for elderly with hearing loss and their families about hearing loss, management, complications and ways to alleviate it.
Compression-based Dependencies Among Rhythmic Motifs in a Score

Music similarity has been widely studied through melodic and harmonic matching, clustering, and using various metrics for measuring distance. Such analyses offer the musicologist a view of the ‘sameness’ of parts of a score. However, similarity alone does not necessarily allow exploitation of that sameness in reasoning about the music. In this paper, we present work in progress to investigate rhythm similarity at various scales, beginning at the smallest (single measures or groups of measures). We use normalised compression distance and variations thereof to derive similarity-based dependencies between parts of the music. Establishing such dependencies may allow software engineering dependence analysis techniques to be applied to music to, e.g. remove from focus aspects not relevant to a particular enquiry (‘slicing’), determine the sensitivity of later parts of the music on former parts (‘impact analysis’), and to find motivic processes and developments within the musical form. The analysis will thus draw on software engineering techniques, information theory, and data compression. Our results thus far show that text-based compressors introduce significant non-linear artefacts at small scales making similarity identification based on compressed lengths difficult. Future work will involve progressively larger scale music to determine the sensitivity of the results to the size of music being analysed in order to guide musicologists wanting to adopt similar approaches. We expect to find that at larger scales, the artefacts in text compression become less significant and identifying the threshold at which this happens is thus important. We discuss tree compression as having the potential to capture musically-important relationships lost by text compression and believe that this approach would be more successful at small scales.
Protective Effect of N-Acetylcysteine on The Kidney and Liver Pathology Induced by NMDA Receptor Antagonist Mk-801 in Mice

Glutamaterjik sistem sinir sisteminde onemli bir sinaps mekanizmasidir. N-metil-D-aspartat (NMDA) reseptorleri bu sistemin onemli bir parcasidir. NMDA reseptorlerinin hipofonksiyonu farelerde kognitif ve motorik sorunlara sebep olmaktadir. MK-801 bu reseptorun oldukca onemli bir blokorudur. 1mg/kg MK-801’in sub-kronik uygulanmasi farelerde sizofreni benzeri semptomlara ve beyinde dejenerasyona sebep olmaktadir. Sunulan bu calismada MK-801’in 1mg/kg’lik sub-kronik uygulamasinin farelerin bobrek ve karacigerlerinde patolojik etkileri olup olmadigi ve N-asetilsisteinin’in (NAS) bu etkiler karsisinda koruyucu etkisinin olup olmadigi arastirildi. Bu amacla 24 adet erkek Balb/C faresi alinarak dort esit gruba bolundu. Ilk grup kontrollerden olustu ve bu gruba %0,9 fizyolojik tuzlu su (10mg/kg) intraperitoneal (i.p.) yolla, ikinci gruba 1mg/kg dozunda MK-801 i.p., ucuncu gruba 1mg/kg MK-801 ile 100mg/kg NAS birlikte i.p ve dorduncu gruba da 100mg/kg NAS i.p. yolla verildi. Ilac uygulamalari 14 gun boyunca surdu. Sakrifiye edilen farelerin karaciger ve bobrekleri alinarak bunlara rutin histoloji proseduru uygulandi. Incelemelerden sonra organlarda histopatolojik degiskilikler ve NAS’in genelde koruyucu etkisinin oldugu gozlendi. Sonuc olarak NAS’in bobrek ve karaciger uzerinde MK-801’le induklenen histopatolojik degisikliklere karsi onemli bir koruyucu etkisinin oldugu ortaya kondu.
Type 2 Diabetes Mellitus in the Acute Coronary Syndrome: Diagnosis, effect on atherosclerotic burden and prognosis

Background: Previously undetected dysglycaemia is common among patients with acute coronary syndromes (ACSs). The aim of this study was to identify the most reliable method of diagnosing type 2 diabetes mellitus (T2DM) and prediabetes in ACS patients. Methods: Patients admitted to the coronary care unit with ACSs and no previous history of T2DM were consecutively included in the study. Glucose metabolism was measured by glycated haemoglobin (HbA1c), fasting plasma glucose (FPG) and 2-hour plasma glucose (2hPG) with a standard oral glucose tolerance test during hospital admission, and this process was repeated 3 months later. In this study, the diagnosis of T2DM required at least two measurements above the diabetes cut-off point according to current American Diabetes Association and World Health Organization criteria. Results: A total of 250 patients were included in the study. T2DM was diagnosed in 7.2%. The sensitivities for detecting T2DM were 33.3%, 61.1% and 77.8% during admission and 27.8%, 61.1% and 72.2% at follow-up for HbA1c, FPG and 2hPG, respectively. The positive predictive values (PPVs) for diagnosing T2DM were 100%, 91.7% and 51.9% during admission and 71.4%, 91.7% and 65.0% at follow-up for HbA1c, FPG and 2hPG, respectively. The specificities and negative predictive values were high for all methods. By combining all measurements, the sensitivity was 100% and the PPV was 44.2%, while the combination of all HbA1c and FPG measurements provided 88.9% sensitivity and 80.0% PPV. Conclusion: Diagnosis of T2DM can be reliably carried out by repeated measurements of FPG and HbA1c in ACS patients, with limited added value of an oral glucose tolerance test.
Breaking Barriers: Could Exercise Supervision Attenuate Kinesiophobia in an Older Cancer Patient?

Background: Kinesiophobia, the fear that movement and physical activity could worsen side effects such as fatigue and pain, is a barrier to exercise in cancer patients. Physical inactivity and deconditioning can lead to functional decline, higher mortality risk and lower quality of life, in older adults, and even more in oncogeriatrics because of a lower physical activity level during cancer treatments. The case: We present the case of an older breast cancer patient recruited in a controlled exercise trial and randomized to the control arm of the study (a 12-week supervised static stretching program). She expressed fear that physical activity might exacerbate some of her cancer-related symptoms during baseline physical capacity assessment (Senior Fitness Test, handgrip strength and maximal lower body strength). After completing the 12-week supervised static stretching program, she exhibited similar and/or larger improvements in many of the physical capacity tests than the mixed exercise intervention group, despite being in the control arm. Conclusions: These observations and physical capacity results have led us to emit the hypothesis that (1) this participant’s baseline physical capacity assessment might have been biased by kinesiophobia and (2) the supervision by exercise physiologist might have mitigated this fear over time. Hence, based on this case, we suggest that kinesiophobia should be measured in future exercise trials and clinical interventions targeting older cancer patients.
Detection of weak D antigen in the population of potential blood recipients

Authors’ contribution Wkład autorów: A. Study design/planning zaplanowanie badań B. Data collection/entry zebranie danych C. Data analysis/statistics dane – analiza i statystyki D. Data interpretation interpretacja danych E. Preparation of manuscript przygotowanie artykułu F. Literature analysis/search wyszukiwanie i analiza literatury G. Funds collection zebranie funduszy Summary Background. The strongest immunogen of the Rh system is the D antigen. It is found in several variants and categories, which makes it difficult to determine the correct RhD (Rh+) or RhD negative (Rh-) phenotype. Although only some of the varieties and types of this antigen are of clinical significance, it is important to determine the normal Rh phenotype in recipients and donors. The aim of this study was to determine the frequency of weak D antigen in a population of potential recipients. Material and methods. The study group consisted of selected blood recipients in whom weak expression of the D antigen or its antibody was detected. In order to estimate the expression of antigen D, the blood was analyzed in the laboratory of the Regional Center of Blood Donation and Blood Treatment in Lublin. Blood from 220 potential recipients (149 women and 71 men) were used in the conducted research. The clinical material from the Laboratory of Transfusion Serology at the Provincial Specialist Hospital in Biała Podlaska was also used. Results. The presence of a weak D was confirmed in 21 recipients. 4 cases of weak D were confirmed among recipients of blood transplant, while 17 cases among those who did not have blood transfusions. There were significant differences in the occurrence of the weak D in relation to the transfusion in both women (χ2 = 18.34 df = 2, p = 0.0001) and men (χ2 = 17.25). Conclusions. The correct determination of the RhD+ or RhDphenotype is important for pregnant women who should be subjected to immunoprophylaxis of maternal-fetal conflict when a weak D is detected. In order to avoid post-transfusion complications among recipients, it is necessary to choose serologically and phenotypically crossed-matched blood components.
Analysis of Gene Transcription Changes Following Chlamydia pneumoniae Infection of THPl Monocytes May Have Relevance to Alzheimer's Disease

There is increasing evidence that neuroinflammation caused by infectious agents is an important etiologic factor in neurodegenerative diseases including Alzheimer's disease (AD). One infectious agent that has been associated with AD is Chlamydia pneumoniae (Cpn). Cpn DNA can be detected within peripherally circulating mononuclear cells and there is evidence that infected mononuclear cells could be involved in chronic infection and contribute to inflammation at numerous anatomical sites, including the brain. Understanding Cpn genetic changes progressing from an acute to a chronic infection within monocytes may help to further elucidate. the role of Cpn infected monocytes with regard to the neurodegeneration observed within AD. In this study, monocytes were infected in vitro with Cpn (either AR39 or CWL029) for 24, 48, 72, 96, or 120 hours. Subsequently, we investigated transcriptional gene changes of 7 Cpn genes using RT- PCR. We found a significant drop in gene expression at later time points in 3 of the genes. Our results demonstrate differences in gene expression from acute to chronic infection that perhaps indicate a trend towards persistence. However, our data does not unequivocally support that these gene changes are representative of the progression from acute to persistent infection. Future studies are required to resolve these differences and determine important gene changes that indicate persistent Cpn infection within monocytes.
Histamine2-Receptor Antagonists, Proton Pump Inhibitors, or Potassium-Competitive Acid Blockers Preventing Delayed Bleeding After Endoscopic Submucosal Dissection: A Meta-Analysis

Background: Endoscopic submucosal dissection (ESD) was commonly used for en bloc resection in gastric cancer and adenoma with the risk of delayed bleeding after ESD. We conducted a direct and indirect comparison meta-analysis to evaluate the best choice in preventing post-ESD bleeding among proton pump inhibitors (PPIs), histamine2-receptor antagonists (H2RAs), and the most widely used potassium-competitive acid blocker, vonoprazan. Methods: The Pubmed, Cochrane Library, and Embase were searched for randomized trials. We pooled odds ratios (OR) for preventing post-ESD bleeding using meta-analysis. Results: Sixteen randomized trials met the inclusion criteria including 2,062 patients. Direct comparisons showed slightly significant efficacy in PPIs rather than H2RAs in preventing post-ESD bleeding [OR: 1.83; 95% confidence interval (CI): 1.10 to 3.05] and vonoprazan was better than PPIs (OR: 0.46; 95% CI: 0.25 to 0.86). The adjusted indirect comparison indicated vonoprazan was superior to H2RAs (OR: 0.30, 95% CI: 0.12 to 0.74). In subgroup analysis, PPIs had similar efficacy as H2RAs in 4 weeks, while PPIs were better than H2RAs in 8 weeks’ treatment (OR: 1.91; 95% CI: 1.08 to 3.40). The superiority of vonoprazan than PPIs was more significant in combination therapy (OR: 0.18; 95% CI: 0.04 to 0.69). There was a significant difference in vonoprazan for 8 weeks of medication (OR: 0.44; 95% CI: 0.21 to 0.92). Conclusions: The effects of vonoprazan is better than PPIs than H2RAs in preventing bleeding after ESD. When vonoprazan combined with mucosal protective antiulcer drug in treatment or used in 8 weeks of medication, the efficacy may be even better.
Identifying a Novel DPYD Polymorphism Associated with Severe Toxicity to 5-FU Chemotherapy in a Saudi Patient

Dihydropyrimidine dehydrogenase (DPD) is the major enzyme in the catabolism of 5-Fluorouracil (5-FU) and its prodrug capecitabine. We report a 65-year-old female with rectal adenocarcinoma who experienced severe toxicities secondary to standard dose 5-FU based chemotherapy. She was found to be heterozygous for rs371313778, c.2434G>A. This finding prompted restarting 5-FU at 50% dose reduction with further titration in subsequent cycles. We herein report the first case of rs371313778, c.2434G>A (p.Val812lle) DPYD polymorphism leading to severe 5-FU toxicities. The patient eventually completed a 6-month course of adjuvant treatment with modification of 5-FU dose.
Effect of nutrient intakes on anthropometric profiles among university students from a selected private University in Klang Valley, Malaysia

Background Dietary composition is the cornerstone of weight management. This study aimed to investigate the effect of nutrient intakes on anthropometric profiles among university students. Methods This cross-sectional study was conducted among 411 students aged 18–29 years, purposive sampled from a selected private university in Klang Valley, Malaysia. Anthropometric profiles were measured. Nutrient intakes were assessed by 3-day 24-hour diet recalls. Results Respondents on average had adequate macronutrient intakes, however, total consumption of dietary fiber and micronutrients were fell short of recommended levels. Significant negative associations were found between body mass index (BMI) and all the macronutrients, calcium, thiamine, riboflavin and niacin. Body fat percentage was significantly associated with all the macronutrients, calcium, zinc, thiamine and niacin. Significant inverse associations were also found between waist circumference and carbohydrate, fiber, thiamine, riboflavin and niacin. Visceral fat showed significant inverse associations with carbohydrate, fat, fiber, thiamine, riboflavin and niacin. Further, after adjusting for sex, gender and race, BMI was associated with niacin (β=-0.161, p=0.027). Body fat percentage was also found significantly associated with niacin (β=-0.180, p=0.002) and riboflavin (β=-0.132, p=0.014). Conclusion Micronutrients, especially B vitamins, are important in weight management among the young adults.
Creating And Testing Vlans Using Network Switches

This paper presents a hands-on undergraduate computer network laboratory exercise in configuring a network switch to create and test four virtual local area networks (VLANs). The objective is to familiarize students with layer 1 (physical layer) and layer 2 (network interface layer or data link layer). The exercise is designed to allow students to discover the need for layer 3 (internet or network) and, in particular, routing protocols to allow communication among the VLANs. In addition students are introduced to a spanning tree algorithm used within a VLAN to prevent bridge loops. The exercise requires students use a network switch, such as the Cisco 3500, to make physical connections between the switch and computers.
New trends in collision detection performance

Collision detection on industrial digital mock-up is one of the challenging problems for real-time interaction in virtual reality applications. The fast increase of graphics hardware performance, multiplication of cores number and recent improvements on their programmability, bring new directions to the optimisation of collision detection algorithms. Since few years methods appear handling General-Purpose Processing on Graphics Processing Unit (GPGPU) and more recently using multi-cores. We present in this survey an analysis on new trends in collision detection performance and we study the use from GPU to grid for virtual reality applications. We not only deal with algorithmic improvement but we propose a first approach on the new link-up between two fields of computer graphics, namely virtual reality (collision detection) and computers performance.
Effects of Both Preemption and Entrenchment in the Retreat from Verb Overgeneralization Errors: Four Reanalyses, an Extended Replication, and a Meta-Analytic Synthesis

How do speakers avoid producing verb overgeneralization errors such as *She covered paint onto the wall or *She poured the cup with water? Five previous papers have found seemingly contradictory results concerning the role of statistical preemption (competition from acceptable alternatives such as She covered the wall with paint or She poured water into the cup) and entrenchment (a mechanism sensitive to all uses of the relevant verb). Here, we use more appropriate measures of preemption and entrenchment (attraction measures based on the chi-square statistic, as opposed to using only the frequency of occurrence in favoured constructions) as well as more appropriate statistical analyses and, in one case, a larger corpus to reanalyse the data from these studies. We find that for errors of verb argument structure overgeneralization (as in the examples above), preemption/entrenchment effects are almost always observed in single-predictor models, but are rarely dissociable, due to collinearity. Fortunately, this problem is much less acute for errors of reversative un- prefixation (e.g., *unsqueeze; *uncome), which could in principle be blocked by (a) non-reversative uses of the same verb root (e.g., squeeze, come; entrenchment), and/or (b) lexically-unrelated verbs with similar meanings to the relevant un- forms (e.g., release, go; preemption). Across a reanalysis of two previous studies of un- prefixation, and a new extended replication with adults, we find dissociable effects of both preemption and entrenchment. A meta-analytic synthesis revealed that, across the studies, both effects are reliable, though preemption appears to increase with age. We conclude that a successful account of the retreat from verb overgeneralization is likely to be one that yields preemption and entrenchment as effects that fall naturally out of the learner’s attempts to communicate meaning, rather than one that treats these effects as mechanisms in their own right, and discuss current accounts that potentially meet this criterion. Finally, we set out some methodological recommendations that can be profitably applied not only to corpus-based experimental studies, but studies of child language acquisition in general.
Development of Multiple Microemulsion Eye Drops for Sustained Release of New Glaucoma Drug

Persistent or repeated elevation of intraocular pressure (IOP) is a primary risk factor of visual field loss in glaucoma, therefore IOP reduction is the first-line therapeutic option in the disease management. Unfortunately, the current therapies are associated with a lot of deficiencies including several daily dosing, reduced efficacy and systemic side effects all of which resulted in poor patient compliance. Previously we have identified Calcium voltage-gated channel auxiliary subunit Alpha2delta 1 gene (Cacna2d1) as a novel modulator of IOP and confirmed that pregabalin targeted CACNA2D1 in eye tissues (ciliary body and trabecular meshwork) to lower IOP in a dose-dependent manner. The research presented in this dissertation aimed to develop a once-daily ocular pregabalin-loaded multiple water-in-oil-in-water microemulsion eye drops. Several in vitro and in vivo evaluations were used to characterize the prepared ophthalmic formulations. Also stability study at 5°C, 25°C, 30°C and 40°C was conducted for four months. All the formulations components were carefully selected to be highly biocompatible that provided a highly transparent eye drops with a miniscule droplet size