Miracle-dz/UniFAR-FTUs huggingface dataset:
The prognostic value of AR in HER2-enriched metastatic breast cancer.

The significance of androgen receptor (AR) in metastatic breast cancer (MBC) remains unclear, and it is still largely unknown how AR expression level influences HER2-positive tumors. This study aimed to investigate the prognostic and predictive value of AR in HER2-enriched MBC. Primary and/or paired metastatic tumors of 304 patients with pathologically confirmed HER2-enriched MBC were collected and immunohistochemically assessed for AR expression. The associations of AR and other clinicopathological characteristics were compared using the Chi-square test. Progression-free survival (PFS) and overall survival (OS) were calculated using the Kaplan-Meier method and log-rank test. Cox regression analysis was used to determine independent prognostic factors. AR-positivity with a cutoff value of 10% was observed in 237 (78.0%) cases, and was associated with longer PFS, 13.2 months, as compared to that of 8.2 months (P = 0.004) in patients with AR-negativity. Moreover, a significant increase in 5-year OS rate (65.3% versus 36.2%, P < 0.001) was also observed for patients with AR-positive tumors. Cox regression analysis identified AR-positivity as an independent prognostic factor of both PFS (hazard ratio = 0.71, P = 0.039) and OS (HR= 0.53, P = 0.013). Additionally, for those who received first-line Trastuzumab therapies, prolonged PFS (15.8 months versus 8.2 months, P = 0.005) and 5-year OS rate (66.2% versus 26.2%, P = 0.009) were observed in AR-positive tumors compared to AR-negative ones. In conclusion, AR was identified as an independent prognostic factor for favorable PFS and OS and could also predict the efficacy of first-line Trastuzumab treatment in patients with HER2-enriched MBC.
J. Gen. Appl. Microbiol., 52, 303–313 (2006)

Vibrio campbellii is a gram-negative, non-luminous bacterium that is widely distributed in marine environments. While its closest relative, Vibrio harveyi, has long been considered as a dominant pathogen of shrimp (dela Peña et al., 2001; Leaño et al., 1998; Sung et al., 1999), V. campbellii has only recently been implicated in diseases of cultured marine organisms and identified as an equally important species involved in shrimp disease. Experimental infection showed that a strain of V. campbellii was pathogenic to black tiger shrimp, Penaeus monodon (dela Peña et Analysis of a gene (vch) encoding hemolysin isolated and sequenced from Vibrio campbellii
User Participation and Democracy: A Discussion of Scandinavian Research on System Development

Scandinavian research projects in system development have traditionally put a strong emphasis on user participation as a strategy for increasing working life democracy. The article analyses a few of these projects with respect to this goal. We argue that there has been a development from politics to ethics in system development research, and that the political dimension should be reintroduced. A reorientation of system development strategies aiming at increasing working life democracy can learn from the historical success stories, in particular the combination of global strategy and local action used in the trade union projects in the 60’s. Recent development in technology and working life will, however, introduce new challenges to system development.
Simulation studies of the Proportional Resonant controller

Paper shows Proportional Resonant controller concept, that can track sinusoidal signals. Results of simulation studies of the 1 phase converter controlled by P+R controller, that connects DC voltage supply (e.g. renewable energy source) with low voltage network, were shown, for typical operational state of the power grid. Streszczenie. W artykule przedstawiono koncepcję regulatora proporcjonalno rezonansowego, który posiada zdolność śledzenia sygnałów sinusoidalnie zmiennych. Zaprezentowano wyniki badań symulacyjnych jednofazowego falownika sprzęgającego źródło napięcia stałego (np. odnawialne źródło energii) z linią niskiego napięcia, wyposażonego w regulator rezonansowy dla typowych stanów eksploatacyjnych (Badania symulacyjne regulatora Proporcjonalno Rezonansowego).
Ruxolitinib use in myelofibrosis patients: the single center experience and the relationship between JAK-2 allele burden and Ruxolitinib response Myelofibrozis hastalarında Ruxolitinib kullanımı: tek merkez deneyimi ve JAK-2 allel yükü ile Ruxolitinib yanıtı arasındaki ilişki

Purpose: Ruxolitinib is an oral JAK-1/2 inhibitor approved for the treatment of splenomegaly and/or constitutional symptoms in intermediate and high-risk myelofibrosis patients. The aim of our study is to evaluate the efficacy and safety of ruxolitinib in primary MF, post-ET MF and post-PV MF patients, to evaluate the relationship between response and JAK-2 allele burden and to compare them with literature data. Materials and methods: In our single centered and retrospective study, we investigated the data of 30 MF patients diagnosed in our clinic between May 2015 and December 2019. We reported demographic features, laboratory values, and spleen sizes. Results: 18 patients (60%) with a median age of 67.5 (45-78) had primary myelofibrosis. Spleen sizes decreased significantly 3 and 6 months after treatment. Constitutional symptoms have disappeared in 28 patients (93.3%). No association was found between JAK-2 allele burden and treatment response success. Conclusion: Ruxolitinib MF is very safe and effective to relieve constitutional symptoms and decrease spleen size. Despite JAK-2 inhibition, no linear relationship was found between JAK-2 allele burden and treatment efficacy.
Topical of Linguistics and Teaching Methods in Business and Professional Communication MULTILAYEREDNESS OF LITERARY PROSAIC TEXT: POLYPHONY VS HOMOPHONY

Any literary text has a complex multilayered structure, a whole set of ideas, images and means that form them. In this regard, the term ‘polyphony’ has become widespread in the field of philology. Drawing the analogy to the musical instrument, we have suggested using the term ‘homophony’ for deciphering the text, in other words, for analyzing its “instrumentation” that can be revealed in a different form and with the help of various devices. The aim of our research, whose results are outlined in this paper, was to receive the confirmation of the significance of rhythmic figures of speech in the context of defining the multilayeredness of the piece of work from the perspective of its structure: identifying its polyphony and/or homophony. In order to facilitate the process of carrying out the analysis we used PRD (ProseRythmDetector) which is a computer-aided application that allows to do the automatic search and quantity analysis of some rhythmic figures. In terms of the main results of the research we can come to the conclusion that rhythmic figures of speech, which are characteristic of a given author’s idiolect, text peculiarities, allow us to find a solution to the problem of polyphony and homophony to some extent. Text cannot be easily attributed either to polyphonic or homophonic, any piece of work is complex in its structure and only the entwinement of thoughts, ideas, linguistic and stylistic devices enables us to enjoy the art of the narrative and the expression of writer’s thoughts. within the text, antithesis, repetition of the keywords, expressions, sentences and episodes
The Ambient Metric

Chapter 1. Introduction 1 Chapter 2. Ambient Metrics 9 Chapter 3. Formal Theory 17 Chapter 4. Poincar'e Metrics 42 Chapter 5. Self-dual Poincar'e Metrics 50 Chapter 6. Conformal Curvature Tensors 56 Chapter 7. Conformally Flat and Conformally Einstein Spaces 67 Chapter 8. Jet Isomorphism 82 Chapter 9. Scalar Invariants 97 Bibliography 107 Index 113
Duality of Anderson T-motives

Let $M$ be a T-motive. We introduce the notion of duality for $M$. Main results of the paper (we consider uniformizable $M$ over $F_q[T]$ of rank $r$, dimension $n$, whose nilpotent operator $N$ is 0): 1. Algebraic duality implies analytic duality (Theorem 5). Explicitly, this means that the lattice of the dual of $M$ is the dual of the lattice of $M$, i.e. the transposed of a Siegel matrix of $M$ is a Siegel matrix of the dual of $M$. 2. Let $n=r-1$. There is a 1 -- 1 correspondence between pure T-motives (all they are uniformizable), and lattices of rank $r$ in $C^n$ having dual (Corollary 8.4).
Roles of circRNAs in the Tumorigenesis and Metastasis of HCC: A Mini Review

Abstract Circular RNAs (circRNAs) are a class of non-coding RNAs with loop structures that are stable and widely distributed in different tumor tissues. The development of high-throughput sequencing and in silico tools has enabled the discovery of numerous functional circRNAs. Hepatocellular carcinoma (HCC) is a malignant tumor, and the mechanism involved in its progression has remained unclear. In recent years, an increasing number of circRNAs have been identified in HCC, contributing to tumorigenesis and metastasis and with the potential role as biomarkers through competitive endogenous RNAs (ceRNAs) as miRNA sponges or by interacting with RNA binding proteins (RBPs). In this review, we summarize the regulatory roles of circRNAs in HCC development as well as the use of bioinformatics tools in the annotation and prioritization of circRNA and highlight the participation of exosomal circRNAs in HCC metastasis and drug resistance.
Cell-free DNA as a Promising Diagnostic Biomarker in Prostate Cancer: A Systematic Review and Meta-Analysis

Objective The detection of cell-free DNA (cfDNA) as a part of “liquid biopsy” of prostate cancer (PCa) has been widely explored. However, its diagnostic value for PCa remains controversial. Based on the data from the latest literature published in the past decade, the present review was conducted to clarify the diagnostic value of cfDNA in PCa. Methods The related studies were systematically searched in the databases of PubMed, Embase, Web of Science, and Cochrane Library from January 1, 2010 to December 1, 2020. Sensitivity (SEN), specificity (SPE), and other relative parameters were pooled using a random model. Results 14 eligible studies with 1049 PCa patients and 973 controls were selected based on the inclusion and exclusion criteria. Results demonstrated that cfDNA showed favorable SPE (0.89, 95% CI: 0.79, 0.94) but unsatisfied SEN (0.56, 95% CI: 0.43, 0.68) in the PCa diagnosis. The positive likelihood ratios (PLR), negative likelihood ratios (NLR), and diagnostic odds ratios (DOR) were 5.1 (95% CI: 3.1, 8.5), 0.49 (95% CI: 0.39, 0.63), and 10 (95% CI: 6, 17), respectively. The summary receiver operating characteristic graph (SROC) with an area under the curve (AUC) of 0.80 (95% CI: 0.76, 0.83) was constructed which indicated favorable diagnostic accuracy for PCa. Results of the subgroup analysis and metaregression analysis reminded “ethnicity” and “methylation” might be sources of heterogeneity. The potential publication bias was not found using Deek's funnel plot asymmetry test (p > 0.05). Conclusions Our meta-analysis illustrated that the cfDNA could undertake a promising role in the PCa diagnosis.
Investigation of Os Coxae in Horses Using Geometric Morphometry Method

1Department of Anatomy, Faculty of Veterinary Medicine, İstanbul University-Cerrahpaşa, İstanbul, Turkey 2 Department of Anatomy, Faculty of Veterinary Medicine, Harran University, Şanliurfa, TURKEY 3Department of Anatomy, Faculty of Veterinary Medicine, Selçuk University, Konya, Turkey aORCID:0000-0002-3637-8166; bORCID: 0000-0002-5000-5075; cORCID: 000-0003-1627-5757; dORCID: 0000-00015986-3992; eORCID: 0000-0002-0724-3019; fORCID: 0000-0002-9354-3519; gORCID: 0000-0002-9354-7480; hORCID: 0000-0003-0368-4607
Intrusion Detection Model for Industrial Internet of Things Based on Improved Autoencoder

With the gradual advancement of informatization and industrialization, the safety and controllability of industrial Internet of things (IoT) have attracted more and more attention. Aiming to improve the security of industrial IoT, a detection method using stacked sparse autoencoder network model is proposed. In this method, the basic units of the network model have been simplified and sparse, and some of basic features are combined with obtaining a higher-level abstract expression, so as to solve the problem of unbalanced network traffic data. The cascaded network structure is adopted to stack its sparse autoencoder network model, so as to improve the data ability of the detection model. In addition, the incorporation of Softmax classifier realizes the dynamic adjustment and optimization of the whole network parameters, which further ensures the efficiency of the detection method. The simulation experiment is based on NSL-KDD dataset. The experiment has proved that the proposed method has excellent network attack identification and detection performance. Its accuracy index is about 95.42%, and the detection time is about 3.42 s.
Anti-adherence and anti-bacterial activities of Pistacia atlantica resin extract against strongly adherent Streptococcus mutans strains

ABSTRACT Background: The reduction of Streptococcus mutans from the oral cavity or its adherence to tooth surfaces can prevent or decrease the progression of caries. In this study, the antimicrobial and anti-adherence properties of Pistacia atlantica (P. atlantica) resin (Essential oil [EO] and methanolic extract [ME]) were investigated on S. mutans strains. Materials and Methods: In this in vitro experimental study, the growth rate, biofilm formation ability, and antibiotic susceptibility profile of S. mutans ATCC35668 and 3 strains isolated from caries lesions were studied. The EO and ME of P. atlantica resin were prepared. The anti-bacterial and anti-adherence properties of them were evaluated using microdilution and microplate adherence tests, respectively. The data were statistically analyzed using SPSS with one-way and two-way analysis variance. Direct comparisons between the groups were made using the Wilcoxon W-Mann–Whitney U-test. Statistical significance was set at P < 0.05. Results: All target strains showed the same growth rate and antibiotic susceptibility profile and were found strongly adherent. Both EO and ME showed moderate anti-bacterial properties (growth reduction up to 47.1% and 39.1%, respectively) against S. mutans, while the anti-bacterial effect of EO was higher than ME, significantly (P < 0.05). In all tested concentrations, EO showed a significantly stronger anti-adherence activity (50%–80%) than ME. Conclusion: The results showed an anti-cariogenic effect of EO extracted from P. Atlantica resin. Considering that S. mutans adhesion is a necessary step in the beginning and progression of dental caries, this study can suggest the use of such extract in mouthwashes or toothpaste as an alternative agent for preventing bacterial attachment and biofilm formation.
Lessons from a Single Amino Acid Substitution: Anticancer and Antibacterial Properties of Two Phospholipase A2-Derived Peptides

The membrane-active nature of phospholipase A2-derived peptides makes them potential candidates for antineoplastic and antibacterial therapies. Two short 13-mer C-terminal fragments taken from snake venom Lys49-PLA2 toxins (p-AppK and p-Acl), differing by a leucine/phenylalanine substitution, were synthesized and their bioactivity was evaluated. Their capacity to interfere with the survival of Gram-positive and Gram-negative bacteria as well as with solid and liquid tumors was assessed in vitro. Toxicity to red blood cells was investigated via in silico and in vitro techniques. The mode of action was mainly studied by molecular dynamics simulations and membrane permeabilization assays. Briefly, both peptides have dual activity, i.e., they act against both bacteria, including multidrug-resistant strains and tumor cells. All tested bacteria were susceptible to both peptides, Pseudomonas aeruginosa being the most affected. RAMOS, K562, NB4, and CEM cells were the main leukemic targets of the peptides. In general, p-Acl showed more significant activity, suggesting that phenylalanine confers advantages to the antibacterial and antitumor mechanism, particularly for osteosarcoma lines (HOS and MG63). Peptide-based treatment increased the uptake of a DNA-intercalating dye by bacteria, suggesting membrane damage. Indeed, p-AppK and p-Acl did not disrupt erythrocyte membranes, in agreement with in silico predictions. The latter revealed that the peptides deform the membrane and increase its permeability by facilitating solvent penetration. This phenomenon is expected to catalyze the permeation of solutes that otherwise could not cross the hydrophobic membrane core. In conclusion, the present study highlights the role of a single amino acid substitution present in natural sequences towards the development of dual-action agents. In other words, dissecting and fine-tuning biomembrane remodeling proteins, such as snake venom phospholipase A2 isoforms, is again demonstrated as a valuable source of therapeutic peptides.
Transcriptomic Analysis Reveals LncRNAs Associated with Flowering of Angelica sinensis during Vernalization

Angelica sinensis is a “low-temperature and long-day” perennial plant that produces bioactive compounds such as phthalides, organic acids, and polysaccharides for various types of clinical agents, including those with cardio-cerebrovascular, hepatoprotective, and immunomodulatory effects. To date, the regulatory mechanism of flowering under the photoperiod has been revealed, while the regulatory network of flowering genes during vernalization, especially in the role of lncRNAs, has yet to be identified. Here, lncRNAs associated with flowering were identified based on the full-length transcriptomic analysis of A. sinensis at vernalization and freezing temperatures, and the coexpressed mRNAs of lncRNAs were validated by qRT-PCR. We obtained a total of 2327 lncRNAs after assessing the protein-coding potential of coexpressed mRNAs, with 607 lncRNAs aligned against the TAIR database of model plant Arabidopsis, 345 lncRNAs identified, and 272 lncRNAs characterized on the SwissProt database. Based on the biological functions of coexpressed mRNAs, the 272 lncRNAs were divided into six categories: (1) chromatin, DNA/RNA and protein modification; (2) flowering; (3) stress response; (4) metabolism; (5) bio-signaling; and (6) energy and transport. The differential expression levels of representatively coexpressed mRNAs were almost consistent with the flowering of A. sinensis. It can be concluded that the flowering of A. sinensis is positively or negatively regulated by lncRNAs, which provides new insights into the regulation mechanism of the flowering of A. sinensis.
Interleukin-4 promotes microglial polarization toward a neuroprotective phenotype after retinal ischemia/reperfusion injury

Glaucoma results from irreversible loss of retinal ganglion cells (RGCs) through an unclear mechanism. Microglial polarization and neuroinflammation play an important role in retinal degeneration. Our study aimed to explore the function of microglial polarization during glaucoma progression and identify a strategy to alleviate retinal neuroinflammation. Retinal ischemia/reperfusion injury was induced in C57BL/6 mice. In a separate cohort of animals, interleukin (IL)-4 (50 ng/mL, 2 μL per injection) or vehicle was intravitreally injected after retinal ischemia/reperfusion injury. RGC loss was assessed by counting cells that were positive for the RGC marker RNA binding protein, mRNA processing factor in retinal flat mounts. The expression of classically activated (M1) and alternatively activated (M2) microglial markers were assessed by quantitative reverse transcription-polymerase chain reaction, immunofluorescence, and western blotting. The results showed that progressive RGC loss was accompanied by a continuous decrease in M2 microglia during the late phase of the 28-day period after retinal ischemia/reperfusion injury. IL-4 was undetectable in the retina at all time points, and intravitreal IL-4 administration markedly improved M2 microglial marker expression and ameliorated RGC loss in the late phase post-retinal ischemia/reperfusion injury. In summary, we observed that IL-4 treatment maintained a high number of M2 microglia after RIR and promoted RGC survival.
Adaptive Neural Network Structure Optimization Algorithm Based on Dynamic Nodes

Large-scale artificial neural networks have many redundant structures, making the network fall into the issue of local optimization and extended training time. Moreover, existing neural network topology optimization algorithms have the disadvantage of many calculations and complex network structure modeling. We propose a Dynamic Node-based neural network Structure optimization algorithm (DNS) to handle these issues. DNS consists of two steps: the generation step and the pruning step. In the generation step, the network generates hidden layers layer by layer until accuracy reaches the threshold. Then, the network uses a pruning algorithm based on Hebb’s rule or Pearson’s correlation for adaptation in the pruning step. In addition, we combine genetic algorithm to optimize DNS (GA-DNS). Experimental results show that compared with traditional neural network topology optimization algorithms, GA-DNS can generate neural networks with higher construction efficiency, lower structure complexity, and higher classification accuracy.
More dissimilarities than affinities between DNAJB11-PKD and ADPKD

ABSTRACT Background Polycystic kidney diseases (PKD) are an important cause of chronic kidney disease (CKD). Autosomal dominant polycystic kidney disease (ADPKD) due to PKD1 or PKD2 mutations is the most common form, but other genes can be responsible for ADPKD and its phenocopies. Among them, a form of atypical ADPKD caused by DNAJB11 mutations (DNAJB11-PKD) has been recently described. Methods We retrospectively recruited a cohort of 27 patients from six different families sharing common ancestries and harboring the same DNAJB11 mutation (c.100C>T, p.Arg34*) and we compared it with a cohort of 42 typical ADPKD patients. Results DNAJB11-PKD patients show small/normal-sized kidneys, with significantly smaller cysts and a slower progression to end-stage kidney disease (ESKD) than ADPKD patients. In the DNAJB11-PKD cohort, the cystic phenotype could not be detected by ultrasound in about half of the patients, but all cases with available computed tomography/magnetic resonance scans displayed cysts. Clinically, DNAJB11-PKD patients displayed proteinuria (mostly albuminuria). Compared with ADPKD, DNAJB11-PKD patients were older and had a higher prevalence of type 2 diabetes mellitus (19% versus 0%; P = 0.007) and nephrolithiasis (62% versus 29%; P = 0.01), whereas the prevalence of cardiac valvular defects was lower (4% versus 51%; P < 0.001). Conclusions Overall, clinical features of DNAJB11-PKD were more subtle compared with those of ADPKD. DNAJB11-PKD shows a unique renal and extrarenal phenotype, clinical presentation and natural history. Therefore our data support that this genetic disease is classified separately from ADPKD.
Low power test architecture for dynamic read destructive fault detection in SRAM

ABSTRACT Dynamic Read Destructive Fault (dRDF) is the outcome of resistive open defects in the core cells of static random-access memories (SRAMs). The sensitisation of dRDF involves either performing multiple read operations or creation of number of read equivalent stress (RES), on the core cell under test. Though the creation of RES is preferred over the performing multiple read operation on the core cell, cell dissipates more power during RES than during the read or write operation. This paper focuses on the reduction in power dissipation by optimisation of number of RESs, which are required to sensitise the dRDF during test mode of operation of SRAM. The novel pre-charge architecture has been proposed in order to reduce the power dissipation by limiting the number of RESs to an optimised number of two. The proposed low power architecture is simulated and analysed which shows reduction in power dissipation by reducing the number of RESs up to 18.18%.