Miracle-dz/UniFAR-FTUs huggingface dataset:
Oral cancer and Precancer in Malaysia The Database and Tissue Resource Bank.

Zain RB, Raja Latifah RJ, Razak IA, Ismail SM, Atiya SA, Hashim BY, Jallaludin A, Bustam AZ, Rahman ZAA, Krishnan G, Kipli NP, Samsudin AR, Nasir WM, Mahadzir WMW, Abraham MT, Norma J, Tay KK, Yuen KM, Cheong SC and Other MOCRI team members. Introduction: Uncoordinated data collection by different research groups prompted the initiation of a Malaysian Oral Cancel Research Initiative (MOCRI) group. Objective: To co-ordinate and standardize data and tissue collection and storage; develop a minimum dataset on risk factors, intervention techniques and quality of life of oral cancer patients. Materials and Methods: A computer software programme is currently being developed to accommodate multi-centre data collection and research activities in eight hospitals. The complete dataset includes parameter on sociodemographic, clinical, pathological, quality of life measures, details of treatment methods, vital status and dietary intake. Tissues are being collected, stored and catalogued as fresh and formalin-fixed in tissue and data collection includes the establishment of oral cancer cell-lines. These tissues are being planned for studies on genetic profile, genetic polymorphism, diagnostic and prognostic markers. Results: Tissues and data on 115 oral cancers 9 leukoplakia and 13 lichen planus has been collected since 2003. Preliminary data from 2004 were analysed for 58 cancer patients. Majority of them more than 60 years old (65.5%) with a mean age of 63.3. Twenty-four (41.4%) were males, 34 (58.6%) females with the majority of them being Indians (56.9%) followed by Chinese and Malays (15.5%, each). Indigenous people of Sabah and Sarawak (12.1%). Eighteen (31%) respondents were smokers, 17 (29.3%) alcohol drinkers and 31 (53.4%) betel quid chewers. Five patients have had histories of family cancers where 3 include immediate family members with head and neck cancers. For the quality of like measures, only 30.2% felt that their daily activities were disrupted despite having advanced cancers. Satellite researches are in progress on genetic polymorphism and tumour markers. One oral cancer cell-line has been established. Conclusion: The establishment of oral cancer database and tissue bank is encouraging and supports on-going satellite researches. Oral Oncology, MacMillan India; 2005. Vol 10: 3-12
Study on the turnover time of different soil organic matter fractions from Hungary

Soil organic matter (SOM) is a complex mixture of materials from various sources and with different stabilization and decomposition processes. The SOM is often divided into several pools with different turnover times and recalcitrance. Models describing the dynamics of accumulation and decomposition of organic carbon generally differenciate components of SOM that turn over on less than 10 years (active pool), 10-100 years (slow pool) and more than 100 years (passive pool) time scales. Analyzes of the carbon isotopic (14C and δ13C) composition of SOM pools are widely used methods to study the turnover rates of these pools. In addition, physical fractionation procedures are used to separate these chemically and physically different SOM compartments from the bulk soil. In general, the SOM associated with the sand fraction can be related to the active pool and the siltand clay-associated SOM represents the relatively stable pools. However, several studies reported contradicting results. Our aim was to determine the different SOM pools by physical fractionation and to measure the turnover time of the separated fractions in order to test the hypothesis that the SOM associated with the finer particles are the most stable. The studied soil sample is a silt loam textured Luvisol from West Hungary with 2.97 % soil organic carbon, 0.145 % total nitrogen content and pH (KCl) 3.72. The soil is collected from the A horizon from deciduous forest vegetation. The soil was incubated for 163 days in constant temperature (20◦C) and moisture (70% water holding capacity) conditions. Maize residues were added to the soil in order to get natural 13C enrichment for stable isotope measurement purposes. The separation into differently stabilized SOM fractions (sand and stable aggregate (S+A), silt plus clay sized (S+C) and chemically-resistant carbon fraction (rSOC)) was done by the method of Zimmermann et al. (2007). The separated fractions were analyzed for 14C and δ13C values. Preliminary results suggests that recent organic matter input does not change the S+C associated SOM. Ages of the SOM in various pools varied in a wide range hence more detailed SOM fractionation would provide more precise results.
Creating a valid in silico Dopamine D2-receptor model for small molecular docking studies

Due to the clinical importance of the Dopamine D2-receptor (D2R) in several brain dysfunctions, the utilization of in silico models for drug development is a growing field of investigation. We provided a transparent and reproducible pipeline for creating a valid D2R model for small molecular docking studies. Furthermore, we suggested a binding pocket for the endogenous ligand of D2R, which was attained upon careful consideration of the available experimental data. Molecular docking studies with Dopamine, Quinpirole and Raclopride allowed also a better understanding of the binding pocket characteristics.
Equation of state for the Lennard-Jones truncated and shifted fluid with a cut-off radius of 2.5 σ based on perturbation theory and its applications to interfacial thermodynamics

ABSTRACT An equation of state is presented for describing thermodynamic properties of the Lennard-Jones truncated and shifted (LJTS) potential with a cut-off radius of 2.5 σ. It is developed using perturbation theory with a hard-sphere reference term and labelled with the acronym PeTS (perturbed truncated and shifted). The PeTS equation of state describes the properties of the bulk liquid and vapour and the corresponding equilibrium of the LJTS fluid well. Furthermore, it is developed so that it can be used safely in the entire metastable and unstable region, which is an advantage compared to existing LJTS equations of state. This makes the PeTS equation of state an interesting candidate for studies of interfacial properties. The PeTS equation of state is applied here in two theories of interfaces, namely density gradient theory (DGT) and density functional theory (DFT). The influence parameter of DGT as well as the interaction averaging diameter of DFT are fitted to data of the surface tension of the LJTS fluid obtained from molecular simulation. The results from both theories agree very well with those from the molecular simulations.
Attentive Visual Semantic Specialized Network for Video Captioning

As an essential high-level task of video understanding topic, automatically describing a video with natural language has recently gained attention as a fundamental challenge in computer vision. Previous models for video captioning have several limitations, such as the existence of gaps in current semantic representations and the inexpressibility of the generated captions. To deal with these limitations, in this paper, we present a new architecture that we call Attentive Visual Semantic Specialized Network (AVSSN), which is an encoder-decoder model based on our Adaptive Attention Gate and Specialized LSTM layers. This architecture can selectively decide when to use visual or semantic information into the text generation process. The adaptive gate makes the decoder to automatically select the relevant information for providing a better temporal state representation than the existing decoders. Besides, the model is capable of learning to improve the expressiveness of generated captions attending to their length, using a sentence-length-related loss function. We evaluate the effectiveness of the proposed approach on the Microsoft Video Description (MSVD) and the Microsoft Research Video-to-Text (MSR-VTT) datasets, achieving state-of-the-art performance with several popular evaluation metrics: BLEU-4, METEOR, CIDEr, and ROUGEL.
Determinants of preterm birth in public hospitals in central Ethiopia: an unmatched case-control study

Background: Around 15 million babies are born prematurely in the world every year. The most common cause of neonatal death in Ethiopia is premature birth. To reduce the rate of preterm delivery by correcting modifiable or preventable causes, the availability of local data is important. Hence, this study aimed to identify the determinants of preterm birth among women who gave birth in public hospitals in central Ethiopia. Methods: An Institutional-based unmatched case-control study was conducted at public hospitals in central Ethiopia to select 170 cases and 340 controls. The collected data were entered into EPI INFO and transferred to SPSS for analysis. Tables, graphs, and proportions were used to present the results. Binary and multiple logistic regressions analysis were computed to identify determinants of preterm birth. Adjusted Odds Ratio (AOR), 95% Confidence Interval (CI), and a p-value < 0.05 were computed to determine the presence of an association between preterm birth and independent variables. Results: A total of 166 cases and 332 controls participated in the study, giving a response rate of 97.6%. Cigarette smoking (AOR=3.77, 95% CI=1.35,10.56), alcohol consumption (AOR=1.85, 95% CI=1.11,3.10), wanted but unplanned pregnancy (AOR=3,95% CI=1.68,5.34), neither wanted nor planned pregnancy(AOR=3.61% CI=1.62,8.06), lack of antenatal care (ANC) visits (AOR=4.13, 95% CI=1.95, 8.74), adverse birth outcomes (AOR=5.66, 95% CI=2.88,11.12), presence of a diagnosed illness (AOR=2.81, 95% CI=1.37, 5.76), presence of one or more of obstetrics complications(AOR=6.44, 95% CI=5.49, 3.35, 9), and hemoglobin level < 11g/dl (AOR=2.78, 95% CI=1.48, 5.22) were determinants of preterm birth. Conclusion:-In this study, cigarette smoking status, alcohol drinking status, pregnancy status, adverse birth outcomes, ANC visits, obstetric complications, presence of medical illness, and anemia were identified as determinants of preterm birth. It is important to encourage such women to attend ANC visits, stop smoking, and abstain from alcohol.
Struktur und Mischungsverhalten von binären Benetzungsfilmen

Die binare Mischung Hexan/Perfluorhexan zeigt im Volumen am kritischen Punkt der Entmischung universelles Verhalten und eine Mischungslucke fur Temperaturen unterhalb von 22°C. Im Rahmen dieser Arbeit wurde uberpruft, ob solches Verhalten auch in sehr dunnen Filmen vorliegt. Benetzungsfilme der Mischung wurden auf Siliziumsubstraten prapariert und mit Rontgenreflektometrie am Synchrotron untersucht, wobei Dichte- und daraus Konzentrationsprofile der Filme bestimmt wurden. Die Filmdicken lagen im Bereich von 25 bis 350 Angstrom bei Temperaturen von 15°C bis 30°C. Die Filme zeigen eine Bildung von zwei Teilphasen, Perfluorhexan ist in der oberflachennahen Phase angereichert. Wie das Volumensystem, so zeigen auch die untersuchten Filme eine Mischungslucke im Bereich niedriger Temperaturen. Das Mischungsverhalten im Film unterscheidet sich jedoch wesentlich von dem des Volumensystems; so verandert sich in Abhangigkeit von der Temperatur nur die Zusammensetzung der oberflachennahen Phase, wahrend die substratnahe Phase stets uberwiegend aus Hexan besteht. Auserdem wird im gesamten untersuchten Temperaturbereich eine Anreicherung des Perfluorhexans an der Oberflache des Films gefunden. Die Ergebnisse zeigen, dass der Substrateinfluss und die endliche Ausdehnung des Films senkrecht zum Substrat bestimmend fur das Verhalten des Films sind.
CFD study of mixing miscible liquid with high viscosity difference in a stirred tank

The mixing process of miscible liquids with high viscosity difference is crucial role even though the solution mutually dissolved. This paper describes the mixing behaviour of the water-molasses system in a conical-bottomed cylindrical stirred tank (D = 0.28 m and H = 0.395 m) equipped with a side-entry Marine propeller (d = 0.036 m) under the turbulence regime using a three-dimensional and transient CFD-simulation. The objective of this work is to compare the solution strategies was applied in the computational analysis to capture the detail phenomena of mixing two miscible liquid with high viscosity difference. Four solution strategies that have been used are the RANS Standards k-ε (SKE) model as the turbulence model coupled with the Multiple Reference Frame (MRF) method for impeller motion, the RANS Realizable k-ε (RKE) combine with the MRF, the Large Eddy Simulation (LES) coupled with the Sliding Mesh (SM) method and the LES-MRF combination. The transient calculations were conducted with Ansys Fluent 17.1 version. The mixing behaviour and the propeller characteristic are to be compared and discussed in this work. The simulation results show the differences of flow pattern and the molasses distribution profile for every solution strategy. The variation of the flow pattern which happened in each solution strategy showing an instability of the mixing process in stirred tank. The LES-SM strategy shows the realistic direction of flow than another solution strategies.
Anomalous grazing-incidence small-angle X-ray scattering of Ga2O3-based nanoparticles

Grazing-incidence small-angle X-ray scattering (GISAXS) performed at several X-ray energies in the vicinity of the absorption edge of a considered element is called anomalous GISAXS (AGISAXS). This emerging technique takes advantage of the variation of the scattering factor near an absorption edge, allowing the morphology of multi-component nanomaterials to be unraveled. The selected model system for AGISAXS simulations is mainly an In2O3 layer containing Ga2O3-based nanoparticles. The transmission coefficients at the different X-ray energies near the Ga K edge are identical at one specific incident angle (near the critical angle). Hence, it could be relevant to perform AGISAXS at this incident angle in order to cancel the transmission modification as the X-ray energy changes. For buried nanoparticles, grazing-incidence effects are negligible with respect to the anomalous element-specific contribution provided that the experiments are performed at energies a few electronvolts below the absorption edge. Interestingly, AGISAXS has a clearly different intensity behavior versus X-ray energy for an embedded monodisperse spherical particle, a hole and a core–shell particle. Hence, AGISAXS can be used to unambiguously distinguish such embedded particles. Moreover, even for a dense layer of core–shell nanoparticles on a substrate, anomalous effects are much larger than grazing effects as the X-ray energy changes. Finally, it is shown that experimental anomalous scattering can be significant and can be satisfactorily simulated.
Mechanisms of transcriptional repression by EWS-FLI1 in Ewing Sarcoma

Ewing Sarkome (ES), die am zweithaufigst auftretenden Tumore der Knochen und Weichteile bei Kindern und Jugendlichen, werden genetisch durch die Genfusion EWS-FLI1 als Folge einer chromosomalen Translokation charakterisiert. EWS-FLI1 kodiert fur einen ausserst potenten Transkriptionsfaktor, welcher sowohl Gen aktivierende als auch Gen repremierende Eigenschaften besitzt. Obwohl EWS-FLI1 als transkriptioneller Hauptregulator in ES fungiert, ist dennoch nur sehr wenig uber Mechanismen der Genregulation und im Speziellen, der transkriptionellen Repression bekannt. In dieser Arbeit konnte gezeigt werden, dass Promotoren von EWS-FLI1 reprimierten Genen eine Anreicherung von Motiven fur Bindung von Forkhead Box Transkriptionsfaktoren zeigen. Des Weiteren konnte FOXO1 als ein EWS-FLI1 reprimierter transkriptioneller Meisterregulator identifiziert werden, welcher signifikant zur repressiven transkriptionellen Signatur von EWS-FLI1 beitragt. FOXO1 wird dabei einerseits direkt durch Bindung von EWS-FLI1 an dessen Promotor transkriptionell, aber auch post-transkriptionell uber inhibitorische Phosphorylierung durch CDK2 und AKT unterdruckt, welche die sub-zellulare Lokalisation und somit die transkriptionelle Aktivitat von FOXO1 regulieren. Durch die funktionelle Re-Expression von nuklearem FOXO1 konnte eine signifikant reduzierte Proliferation, als auch Klonogenizitat in ES Zelllinien in vitro gezeigt werden. Profile von Experimenten zur Genexpression konnten zeigen, dass es eine signifikante Uberlappung zwischen EWS-FLI1 reprimierten und FOXO1 aktivierten Genen gibt. Eine Reaktivierung von endogenen FOXO1 durch Verwendung von Methylselen Saure (MSA), im Beisein von EWS-FLI1, konnte eine Zeit- und Konzentrations-Abhangigkeit sowie Induktion von Zelltod, welcher zumindest teilweise auf die Reaktivierung von FOXO1 zuruckzufuhren ist, in vitro bewirken. Durch Verwendung eines orthotopen Maus Xenograft Modells konnte gezeigt werden, dass MSA behandelte Mause ein signifikant verringertes Tumor Wachstum und gleichzeitig erhohte FOXO1 Expression aufweisen. Zusammenfassend konnte gezeigt werden, dass eine EWS-FLI1 vermittelt repressive Sub-Signatur durch die Unterdruckung des Tumorsuppressors FOXO1 ausgelost ist. Deshalb konnte die Reaktivierung von FOXO1 durch niedermolekulare Substanzen eine neue therapeutische Strategie zur Behandlung von ES Patienten darstellen.
The Potential Of Gluten Free Flour Enriched With Resistant Starch Type 3 From Canna Edulis For The Management Profile Of Glucose, Lipids And Short Chain Fatty Acid In Healthy Mice

This research aims to modifying Canna edulis flour to improve resistant starch content and identifying the effect of consumption of gluten-free enriched with resistent starch type 3 from Canna edulis flour toward profil of glucose, lipids and short chain fatty acids in healthy mice. Production of Canna edulis flour rich in resistant starch type 3 with modifications of 3 cycle autoclaving-cooling, and then formulation of the 3 types of glutenfree enriched RS3 from Canna edulis flour. In-vivo analysis was performed using the 24 rats wistar divided into 4 groups: the standard feed, high protein gluten free flour, high fiber gluten-free flour, and all purposes gluten-free flour. Evaluation in vivo done to know the profile of glucose, lipids and short chain fatty acids. The results show that 3 cycle autoclaving-cooling can increase the level of resistant starch at 39.5%. Diet of three types of gluten free can control the profile of glucose and lipids compared to standard feed. The main short chain fatty acids were acetic acid, propionic acid and butyric acid. This indicates that consumption of three types of gluten-free flour enriched RS3 from Canna edulis flour provides positive benefits for profiles of glucose, lipids and short chain fatty acids.
Laminar Burning Velocity of n-Propanol and Air Mixtures at Elevated Mixture Temperatures

The present work reports the measurement of the laminar burning velocity for n-propanol and air mixtures at 1 atm pressure, with the unburnt mixture temperature varying up to 620 K using externally heated mesoscale diverging channels. Planar flames were stabilized in quartz channels using an externally heated mesoscale diverging channel to create a positive temperature gradient along the direction of fluid flow. The laminar burning velocity was extracted using the mass conservation principle at the flame surface and channel inlet. The performance of six recent kinetic mechanisms was evaluated through a comparison of the predictions to present experimental results. A significant disagreement (≈22%) was observed between different mechanism predictions, even at lower mixture temperatures of 335 K. The temperature exponent, α, was extracted using power-law correlations and observed to follow an inverted parabolic pattern with a minimum at a slightly rich equivalence ratio of 1.1, similar to other alcohol fuels.
Optical quality control using deep learning

Optical quality control is still often performed by people and always carries the risk of human error. A modern approach in order to solve this issue is the usage of artificial intelligence to boost performance and reliability. This paper focuses on implementing a prototype for optical quality control based on the YOLOv3 algorithm. This is a state-of-the-art object detection system that uses deep learning to detect different classes of objects within an image. Instead of different kinds of objects, the classes in this prototype were different quality levels of a strawberry. The dataset for this task was gathered by taking photos and using images from the internet. The strawberries on these images were labeled and fed to the YOLOv3 algorithm for training. Despite the poor detection rate, the results showed that it is generally possible to use such systems for detecting different quality levels of products.
Fuzzy logic model to predict oil-film pressure in a hydrodynamic journal bearing lubricated under the influence of nano-based bio-lubricants

ABSTRACT The present investigation was carried out to predict the oil-film pressure of a chemically modified rapeseed oil (CMRO) containing nano CuO/WS2/TiO2 using Response Surface Methodology (RSM) based D-optimal design. A fuzzy logic model has been developed to predict the oil-film pressure of journal bearing lubricated under the various nano-based bio-lubricants. The results confirmed that the fuzzy logic model is capable of predicting the optimum oil-film pressure of a hydrodynamic journal bearing lubricated under nano-based bio-lubricants.
Ultimate Capacity Analysis of Concrete-Filled Steel Tubular Structure under Eccentric Compression

With the theory of updated lagrangian (U.L.) finite element formulation, the incremental equation of virtual work of a three-dimensional (3D) beam for a geometric non-linear analysis of the space structure is established. Material constitutive relation relationships, considering restriction effect, of both outer steel and core concrete, are proposed in the paper. Based on the nonlinear finite element method and fiber model, the whole load-deflection curves and ultimate bearing capacity of short and long concrete filled steel tubular (CFST) members under eccentric compression are presented and discussed. The efficiency and applicability of the proposed method are proved by comparison results. The members with larger eccentric distances have lower ultimate bearing capacity, but have better ductility.
Optimalisasi Ekstraksi dan Uji Metabolit Sekunder Tumbuhan Libo (Ficus variegate Blume)

Tumbuhan Libo (Ficus variegate Blume) merupakan salah satu tumbuhan liar, dan bagian daunnya tidak pernah dimakan oleh ulat. Pada Tahap ini dilakukan optimalisasi teknik ekstraksi dan menguji metabolit sekunder daun libo. Optimalisasi dilakukan dengan mengubah berbagai variabel yaitu metode ekstraksi, variasi jumlah pelarut, dan lamanya waktu ekstraksi. Efektivitas ekstraksi dilihat dari %rendemen yang dihasilkan. Metode yang digunakan adalah maserasi dan soxhlet, sedangkan pelarut yang digunakan adalah metanol dengan variasi jumlah pelarut 1:10, 1: 20, 1:30 serta variasi waktu ekstraksi (1,2,3 4 dan 5 hari untuk maserasi dan 1,2,3,4 dan 5 siklus untuk metode soxhlet). Hasil yang didapat dari penelitian ini adalah metode terbaik untuk ekstraksi daun libo adalah metode soxhlet dengan % rendemen 34,00 dengan perbandingan pelarut 1:30 dengan lama ekstraksi sebanyak 5 siklus. Dari pengujian metabolit sekunder diketahui daun Libo ini mengandung fenol, flavonoid dan alkaloid.