Miracle-dz/UniFAR-FTUs huggingface dataset:
ComponentsoftheVid30c areneeded for the rapamycin-induced degradationofthe high-a⁄nityhexose transporterHxt7p in Saccharomyces cerevisiae

Saccharomyces cerevisiae adapts to changing nutrient conditions by regulating its genome-wide transcription profile and cell-wide protein complement in correlation with the reigning nutrient conditions. The target of rapamycin (TOR) signalling pathway is one of the major control mechanisms within the cell that facilitates these changes. The transcription, intracellular trafficking, and protein turnover of nutrient transporters, including the hexose transporter proteins (Hxts), are regulated in response to nutrient conditions. The Vid and Gid proteins facilitate the nutrient-dependent degradation of the gluconeogenic enzymes FBPase and Mdh2p when glucose-starved cells are replenished with glucose. Three members of the VID and GID gene families, VID30/GID1, GID2, and VID28/GID5 are needed for the rapamycin or nitrogen starvation-induced degradation of the high-affinity hexose transporter Hxt7p is shown here. In addition, evidence that the functions of several Vid and Gid proteins are in close relation to the TOR signalling pathway is provided.
Qualitative Analysis of Siro-spun and Two Fold Yarns Tensile Properties under the Influence of Twist Factor

Siro yarns are spun from two separate roving of same type of materials. Similarly in textile arts, folding is a process used to create a strong and balance yarn by putting together two separate yarns. Hence, this research study was carried to analyse the quality of Siro-spun and two fold yarns under the influence of twist factor with special reference to their tensile properties. The results disclosed better tensile properties of yarn made from Siro spinning technique as compared to two plied yarn. This indicates the supremacy of Siro-spun yarn over two fold yarn. These findings enhance the fact that Siro spinning technique produces better quality yarn as compared to conventional ring spinning technique.
In-Field Calibration Method for DTG IMU Including g-Sensitivity Biases

Navigation performance can be significantly enhanced by the inertial measurement unit (IMU) calibration. Aiming at the dynamically tuned gyro IMU, a novel in-field calibration method is proposed in this paper. Taking gravity and earth’s rotation rate as a reference, all accelerometer errors, the constant biases, and the g-sensitivity biases of gyro can be calibrated using the unscented Kalman filter based on the norm-observed method. The scale factor errors and installation errors of gyro can be estimated though the Kalman filter with velocity errors as observation. In order to guarantee that all error parameters are observable, a 26-position and its optimized 12-position rotation schemes are designed. The proposed method can achieve correct calibration without a high-precision turntable. Besides, it can improve the ability of analysis and the deviation of interference sources when some error parameters are calibrated unreasonable. The simulations and in-field calibration experiments are conducted to verify the effectiveness of the proposed method. The simulations demonstrate that the calibration accuracy of two schemes is almost equivalent. Compared with the system-level calibration, the calibration results of two schemes are within a reasonable range. The semi-physical simulations indicate that finding out and separating interference sources can be achieved easily with the proposed method. Thus, the proposed method has great application values in in-field calibration.
University of Birmingham Realizing active inference in variational message passing

Active inference is a state-of-the-art framework in neuroscience that offers a unified theory of brain function. It is also proposed as a framework for planning in AI. Unfortunately, the complex mathematics required to create new models — can impede application of active inference in neuroscience and AI research. This paper addresses this problem by providing a complete mathematical treatment of the active inference framework — in discrete time and state spaces — and the derivation of the update equations for any new model. We leverage the theoretical connection between active inference and variational message passing as describe by John Winn and Christopher M. Bishop in 2005. Since, variational message passing is a well-defined methodology for deriving Bayesian belief update equations, this paper opens the door to advanced generative models for active inference. We show that using a fully factorized variational distribution simplifies the expected free energy — that Submitted to Neural Computation
HEPATOPROTECTIVE AND ANTIDIABITIC EFFECTS OF AQUEOUS Moringa oleifera LEAVES EXTRACT ON EXPERIMENTAL RATS

This study was designed to determine the total phenols , flavonoids and antioxidative effect of aqueous Moringa oleifera Leaves extract (AMLE) on the biochemical profile of hepatic dysfunction and diabetic male rats. It was found that AMLE contained 698.82 mg/g of total phenolic compounds , 26.33 mg/g of total flavonoids and antioxidant activity (DPPH) recorded 81.6%. Also, the results indicated that e-vanillic acid (1988.32 ppm) and syringic acid (898.25ppm)were the dominant phenolic compounds in AMLE. Concerning the biological assay, the obtained results showed that there were significant differences between only Lipopolysaccharides (LPS) treated group and those treated with LPS followed by AMLE or AMLE followed by LPS. Where, it could be noticed that there were significant decreases in all liver function values except for serum albumin,which increased and reached to 4.00 mg/dl in treated group with AMLE followed by LPS. In addition , AMLE improve kidney functions. Also, antioxidant enzyme concentrations (SOD) increased in treated group with AMLE group followed by treated group with LPS and reached 30.33 U/L. On the other, hand the treatment with AMLE decreased LDL-cholesterol and increased HDL-cholesterol levels at the end of experimental period compared with those of LPS treated group . As biochemical indices, it could be noticed that blood glucose recorded an improvement in group treated with amaryl drug (167.66 mg/dL) and AMLE group (180.66 mg/dL) compared with Streptozotocin (STZ ) group (306.66 mg/dL). Conclusively, it briefly could concluded that aqueous Moringa olifieria leaves extract had vital effects to prevent LPS induced hepatic dysfunction and gluscose blood level by its high content of polyphenols.
ORAL UTILIZATION CAM IN DERMATOLOGY COMPARED TO MEDICINE OVERALL PAKISTAN USING THE ANNUAL AMBULATORY MEDICAL CARE SURVEY

Aim: Reciprocal and elective medicine (CAM) has a growing role in dermatology. Reciprocal therapies have been focused in many disorders of the scalp, including atopic dermatitis and psoriasis. Methods: This investigation was undertaken using the National Ambulatory Medical Care Study to examine oral CAM use in dermatology relative to medications in general in Pakistan. Our current research was conducted at Jinnah Hospital, Lahore from May 2019 to April 2020. The envisaged variables incorporate the characteristics, analyzes and CAM of the patient section reported during the visits. A succinct review of the key 6 CAM medicinal items novel to dermatology visits was carried out. Results: Most CAM clients in both dermatology and medicine were all female and white and covered with private defense or Medicare. Fish oil, glucosamine, glucosamine chondroitin and omega-3 were the most commonly known integral enhancements used in both instances. Conclusion: CAM use in dermatology has all the earmarks that are necessary for a broader pattern of medications. Details on standard correlative therapies can help dermatologists explore this widening area.
A poly-uridine insertion in the 3 ’-untranslated region of classical swine fever 1 virus activates immunity and reduces viral virulence in piglets 2

word count: 248 17 Text word count: 6261 18 19 JVI Accepted Manuscript Posted Online 23 October 2019 J. Virol. doi:10.1128/JVI.01214-19 Copyright © 2019 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. on M arch 6, 2020 by gest http/jvi.asm . rg/ D ow nladed fom
Système d’organisation de rendez-vous hétérogène et application à la diffusion de rumeurs

: In this paper, we describe a fully decentralized algorithm, called ”dating service” to organize communications into a fully heterogeneous network, that ensures that communication capabilities of the nodes are not exceeded. We prove that with high probability, this service ensures that a constant fraction of all possible communications is organized. Inter-estingly enough, this property holds true even if a node is not able to choose another node uniformly at random. We also present, as an application of the dating service, an algorithm for rumor spreading that enables to broadcast a unit-size message to all the nodes of a P2P system in logarithmic number of steps with high probability.
Differential contributions of AF1 and AF2 activities to the developmental functions of RXR α

Retinoids (vitamin A derivatives) are crucial for many aspects of vertebrate physiology and homeostasis (reviewed in Sporn et al., 1994). They also play essential roles in morphogenesis and organogenesis, as inferred from the large spectrum of developmental abnormalities displayed by vitamin Adeficient (VAD) fetuses (reviewed in Kastner et al., 1995; Dickman et al., 1997; White et al., 1998). Two families of nuclear receptors for retinoids, the RARs ( α, β and γ isotypes and their isoforms; activated by all forms of retinoic acid, RA) and the RXRs (α , β and γ isotypes and their isoforms; activated by 9-cisRA only) transduce the retinoid signal. RARs and RXRs act in transfected cells in vitro as liganddependent transcriptional transregulators through binding as RAR/RXR heterodimers to cis-acting RA response elements present in cognate reporter genes (reviewed in Leid et al., 1992; Chambon, 1996; Mangelsdorf et al., 1995; Mangelsdorf and Evans, 1995). In addition, RXRs can act as heterodimerization partners with nuclear receptors other than RARs, such as thyroid hormone receptors, vitamin D3 receptor, peroxisome proliferator activated receptors and several orphan receptors (reviews: Mangelsdorf and Evans, 1995; Chambon, 1996; Perlmann and Evans, 1997). Importantly, RAR-specific and RXR-specific ligands synergize to activate target genes or to elicit biological responses in cell systems (Taneja et al., 1996; Taneja et al., 1997; Roy et al., 1995; Chen et al., 1996; Horn et al., 1996; Nagy et al., 1995; Vivat et al., 1997), as well as in whole embryos (Minucci et al., 1996; Minucci et al., 1997; Lu et al., 1997), indicating that both partners of the RAR/RXR heterodimer can be transcriptionally active. However, the liganded RXR is not active unless its RAR partner is itself liganded (Roy et al., 1995; Apfel et al., 1995; Chambon, 1996; Taneja et al., 1996; Taneja et al., 1997; Chen et al., 1996; Vivat et al., 1997; Botling et al., 1997). To investigate the involvement of RARs and RXRs in the transduction of retinoid signals under physiological conditions in vivo, all RAR and RXR genes, and most of their isoforms have been knocked out in the mouse (for reviews see Kastner et al., 1995; Mark et al., 1999). Altogether, these studies have ed to several important conclusions concerning the role of these receptors during morphogenesis and organogenesis: (1) RARs and RXRs mediate the developmental functions of RA; (2) functional redundancies exist among the various RARs and among the various RXRs; (3) RAR/RXR α heterodimers are most likely the main functional units that transduce the retinoid signal during development; (4) transcriptional activation of both partners in RAR/RXRα heterodimers are often required to activate target genes and to mediate under 2049 Development 128, 2049-2062 (2001) Printed in Great Britain © The Company of Biologists Limited 2001 DEV2710
Endogeneous Borders

A large literature on “border effects” in the wake of McCallum (1995) documents the massive impact of borders on trade. However, all these studies suffer from an identification problem. “Border effects” are usually identified from cross-sectional variation alone. We do not know how trade would change in response to a change in borders – the “treatment effect” of borders on trade – simply because trade flows across “future” borders are typically not documented. Nor can we rule out that that there is “reverse causation”: that borders run along pre-existing trade patterns rather than shape trade flows. We exploit a natural experiment from history to explore this issue: the many dramatic border changes that were imposed and codified by the peace treaties in 1919 across Europe. We follow Ritschl and Wolf (2008) and implement Ashenfelter’s difference-in-difference estimator in levels on a large, new data set on sub-national trade flows. This allows us to trace the effects of changing borders over time and produces two key results: first, new borders have a large effect on trade. However second, the “treatment effects” of borders tend to be significantly smaller than the pure cross-sectional effects,. This is so, because most of the 1919 border changes followed a pattern of trade relations across the region that was clearly visible already before 1914. Borders shape trade, and trade shapes borders.
Elevated Expression of the Rat Somatic Cytochrome c Gene in COS-1 Cells

To investigate the transcriptional control of nuclear-encoded respiratory genes in mammals, we have performed a deletional analysis of cis-acting regulatory sequences in the rat somatic cytochrome c gene. Three major regions are required for maximal expression of the transfected gene in kidney cell lines CV-1 and COS-1. One of these, region III (+71 to + 115 from the transcription initiation site), is an unusual intragenic controlling element found in the 5' end of the first intron, while the other two, region I (-191 to -165) and region II (-139 to -84), define the upstream promoter. Region II contains two consensus CCAAT boxes and mediates a constitutive level of expression in both cell lines. In contrast, regions I and III are both required for the increased promoter activity observed in COS-1 cells compared with promoter activity observed in CV-1 cells, and the regions function individually as competitors with the full promoter for trans-acting factors or complexes. Region III contains a perfect octanucleotide homology with region I in addition to a consensus Spl-transcription-factor-binding site. Promoter stimulation in COS-1 cells can be duplicated in CV-1 cells by cotransfecting with a T-antigen-producing vector, but purified T antigen does not bind anywhere in the cytochrome c promoter. A control promoter from the mouse metallothionein I gene is similarly activated in T-antigen-producing cells only in the presence of zinc, which activates its upstream regulatory sites. We conclude that T antigen stimulates these cellular promoters through the activation or induction of cellular factors or complexes that mediate their effects through promoter-specific regulatory elements. Cytochrome c promoter regions activated in this system may play a physiological role in controlling gene expression.
Phase Diffraction Optical Elements with Enhanced Efficiency for Nanoscopy

This paper summarizes the studies on creation of the special phase diffraction elements. These elements can be used for forming the light fields with two maxima in the intensity distribution and with the ability to rotate during focusing and propagation. The diffraction optical elements are based on the optics of spiral light beams and can be used to modify the point spread function of an optical fluorescence microscope to create a nanoscope, i.e. a device that allows the three-dimensional localization of emitting objects with nanometer accuracy
Post Deployment Secure Key Management in Wireless Ad hoc Networks

— Providing secure communication between nodes in mobile ad hoc networks is critical in many applications. In this paper, we present our work on a key distribution scheme for mobile ad hoc networks. Unlike traditional key distributions which establish encryption keys prior to node deployment we devise a post-deployment key distribution scheme to allow nodes a higher chance of connectivity with neighboring nodes. At the same time, nodes are able to be highly mobile within the network while reducing the need for excessive storage of encryption keys by each node in the network.
Distribution of supersingular primes

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The interaction of T-Tauri stars with molecular clouds

Winds from T-Tauri stars may provide an important dynamical input into cold molecular clouds. If the frequency of T-Tauri stars exceeds 20/cu pc, wind-driven shells collide and form ram-pressure-confined clumps. The supersonic clump motions can account for cloud line widths. Clumps collide inelastically, coalescing and eventually becoming Jeans unstable. For characteristic dark cloud temperatures low-mass stars form, and it is speculated that in this manner clouds can be self-sustaining for 10 million to 100 million yr. Only when either the gas supply is exhausted or an external trigger stimulates massive star formation (for example, by heating the cloud or enhancing the clump collision rate), will the cloud eventually be disrupted. A natural consequence of this model is that dark cloud lifetimes are identified with the duration of low-mass star formation, inferred to exceed 10 million yr from studies of nearby star clusters. Other implications include the prediction of the existence of embedded low-mass stars in turbulent cloud cores, the presence of an internal source of radiation in dark clouds, and a clumpy structure for cold molecular clouds.
CharacterizationofDhKHA1,a gene coding fora putative Na transporter fromDebaryomyceshansenii

The KHA1 gene from Debaryomyces hansenii has been identified and characterized by heterologous expression in Saccharomyces cerevisiae. The gene is orthologous to ScKHA1, previously reported in S. cerevisiae, and on the basis of the deduced amino acid sequence, DhKha1p can be classified as an Na/H transporter. Reverse transcriptase (RT)-PCR experiments indicated that the expression level of DhKHA1 was not dependent on high pH or on the presence of a high salt level in the growth medium. Overexpression of DhKHA1 in a salt-sensitive S. cerevisiae mutant (ena1-4 nha1 kha1) rendered cells specifically more tolerant to Na. In addition, internal K and Na measurements and experiments performed with green fluorescence protein (GFP)-tagged DhKha1p indicated the intracellular localization of this protein when expressed in S. cerevisiae.
CONTACTLESS DIAGNOSTICS OF INDUCTION MOTORS FOR HYDRAULIC UNITS

In the case of energy-efficient drives with induction motors, the tendency to implement optimally designed motors, combined with intelligent control, incorporating an integrated monitoring and diagnostics system, is becoming increasingly important. Induction motors in industrial systems operate with frequent starting, dynamic loads and sometimes unbalance of supply voltage. In order to maintain an optimal operating condition, reduce the number of failures and build up an optimal repair and maintenance system, it is important to have an advanced monitoring system coupled with fault identification techniques. The behavior of optimally designed three-phase induction motors designed to operate integrated into hydraulic units with continuous duty operating mode is considered.
Between Default Swap, Growth and Deficit: A Case of

kavram önemli riskini büyüme Çalışmada büyüme cari ilişki 2007:Q2-2018:Q4 için Kapetanios (2005) birim kök testi, Maki (2012) eşbütünleşme testi ve Fourier Toda-Yamamoto nedensellik testi analiz edilmiştir. Elde edilen sonuçlar teorik açıdan cari açığın ekonomide riski primi ve CDS oranlarında artışa olduğu olup; Türkiye'ye yönelik risk algısının with CDS. In this regard, this relationship was investigated for the period of 2007:Q2-2018:Q4 by using Kapetanios (2005) unit root test, Maki (2012) cointegration test and Fourier Toda-Yamamoto causality test. Obtained results suggested that the current account deficit and the economic constriction caused an increase with the country's external borrowing risk, and that risk perception towards Turkey was found to be affected by the concerned macroeconomic variables.
Review on Molecular Diagnostic Techniques in Friedreich’s Ataxia

Friedreich’s ataxia is a commonly inherited neurodegenerative disease with an autosomal recessive pattern of inheritance, and was described by Nikolaus Friedreich first in 1863. Friedreich’s ataxia is caused due to hyperexpansion of the intronic GAA trinucleotide repeats or mutations in the FXN gene on chromosome 9q13. This gene codes for a mitochondrial protein, frataxin, which is highly conserved in many species and has functions in iron-sulfur cluster biosynthesis. Friedreich’s ataxia mainly results from a deficiency of the frataxin protein, due to mutations in the FXN gene. Formation of sticky DNA, formation of DNA-RNA hybrid and epigenetic changes, including methylation of DNA and histone modifications, are the proposed mechanisms for disruption of FXN gene expression. Most cases of Friedreich’s ataxia are homozygous and caused due to expansion of the GAA trinucleotide repeat in the first intron of the FXN gene, however, some cases can be heterozygous, with GAA expansion in one allele and point mutation or deletion in the FXN gene on the other allele. Therefore, diagnosis of the disease based on only the clinical symptoms becomes difficult. Molecular diagnosis is, therefore, important, in order to detect GAA repeat expansions as well as mutations in the FXN gene. This review represents an overview of the molecular diagnostic studies in Friedreich’s ataxia, including an overview of the disease, as well as the gene and protein involved in the disease and techniques that can be useful in diagnosis of the Friedreich’s ataxia. The described methods include tools that are based on analysis of DNA as well as analysis of mRNA and Review Article Annual Review & Research in Biology, 3(4): 659-677, 2013 660 protein levels. A brief description of mutations found in compound heterozygous Friedreich’s ataxia patients, is also provided.
G-CSF Reactivates Human Cytomegalovirus in a Latently Infected Humanized Mouse Model

Human cytomegalovirus (HCMV) continues to be a significant cause of morbidity and mortality in organ transplant recipients despite the availability of antiviral therapy. Considerable controversy exists regarding the use of granulocyte-colony stimulating factor (G-CSF) mobilized blood products from HCMV seropositive donors during stem cell transplantation (SCT) and in patients receiving granulocyte transfusions to treat neutropenia. In order to understand mechanisms of HCMV transmission to patients receiving G-CSF mobilized blood products, we generated a novel NOD-scid IL2Rγc humanized mouse model in which HCMV establishes a latent infection in human hematopoietic lineage cells. In this model, G-CSF induces the reactivation of latent HCMV in monocytes/macrophages that have migrated into organ tissues. These results suggest that the use of G-CSF mobilized blood products from seropositive donors pose an elevated risk for HCMV transmission to recipients.