Miracle-dz/UniFAR-FTUs huggingface dataset:
Length Matters: Short Base‐Plate Angle Guides May Lead to Guide‐Wire Mal‐Positioning When Inserting a DHS. A Radiographic Modeling Study

The dynamic hip screw (DHS) consists of a barrel‐plate fixed to the relatively‐straight proximal femoral shaft, and a screw which slides within the barrel at a fixed angle, usually 135°. The guide‐wire is inserted using a guide at the set angle. Guide design varies between manufacturers, with some new guides being particularly short. We analysed the impact of guide design on the resulting trajectory of the guidewire, and its potential to cause a surgical error. Twenty AP hip radiographs were analysed. Trauma Cad (Brainlab, Munich, Germany) software was used to template a 4‐hole 135° DHS onto the intact femur with the screw positioned in the center of the head. A template of a Stryker (Michigan, USA) 135° DHS guide (37 mm long) was then overlaid at the hip screw entry point, and the set trajectory marked. The divergence between the two trajectories was measured (α angle). The distance the guide would have to be moved inferiorly to attain the correct position in the head was then noted. The median divergence (α angle) caused by the guide relative to the ideal position was 6° (range 2–12). This led to the guidewire placement being a median of 9.1 mm (range 3–23) superior in the head (β). To achieve the correct position of the wire in the head, the guide needed to be moved inferiorly a median of 8 mm (range 2–10). © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:574–577, 2020
Analyzing a networked social algorithm for collective selection of representative committees

A recent work (Hernández, et al., 2018) introduced a networked voting rule supported by a trust-based social network, where indications of possible representatives were based on individuals opinions. Individual contributions went beyond a simple vote-counting and were based on proxy voting. This mechanism selects committees with high levels of representativeness, weakening the possibility of patronage relations. By incorporating the integrity of individuals and its perception, we here address the question of the resulting committee’s trustability. Our results show that this voting rule provides sufficiently small committees with high levels of representativeness and integrity. Furthermore, the voting system displays robustness to strategic and untruthful application of the voting algorithm.
Improved Memory Properties of Graphene Oxide-Based Organic Memory Transistors

To investigate the behaviour of the organic memory transistors, graphene oxide (GO) was utilized as the floating gate in 6,13-Bis(triisopropylsilylethynyl)pentacene (TIPS-pentacene)-based organic memory transistors. A cross-linked, off-centre spin-coated and ozone-treated poly(methyl methacrylate) (cPMMA) was used as the insulating layer. High mobility and negligible hysteresis with very clear transistor behaviour were observed for the control transistors. On the other hand, memory transistors exhibited clear large hysteresis which is increased with increasing programming voltage. The shifts in the threshold voltage of the transfer characteristics as well as the hysteresis in the output characteristics were attributed to the charging and discharging of the floating gate. The counter-clockwise direction of hysteresis indicates that the process of charging and discharging the floating gate take place through the semiconductor/insulator interface. A clear shift in the threshold voltage was observed when different voltage pulses were applied to the gate. The non-volatile behaviour of the memory transistors was investigated in terms of charge retention. The memory transistors exhibited a large memory window (~30 V), and high charge density of (9.15 × 1011 cm−2).
Flexible, High Power Density, Wearable Thermoelectric Nanogenerator and Self-powered Temperature Sensor.

We propose a flexible and wearable thermoelectric nanogenerator (FTEG) made from Bi2Te3, which allows high voltage and output power density. The proposed FTEG works as a thermopile with the end-to-end connection of 126 thermoelectric legs, and which is fabricated through magnetron sputtering Cu conductor on PET film. Bi, Te, Sb and Se alloys are used to prepare thermoelectric materials by doping in a fixed proportion and zone melting, and nickel plating on the surface mitigates the deterioration of thermoelectric properties caused by the diffusion of Cu atoms or Cu+ ions. The thermoelectric figure of merit is stable and maintained above 0.7, up to 1.02. More flexibility is allowed by employing double sinusoidal serpentine connecting wires, and no significant property changes are observed even after being folded 200 times. When the temperature difference reaches 50K, the output voltage of the FTEG will be no less than 520mV, and the power density will reach 11.14mW·cm-2. By integrating a low-power, low-threshold voltage boost circuit on the back end of the FTEG, the electronic watch with a LCD screen can be easily powered to work properly. Furthermore, the FTEG is temperature-sensitive thus can be used for temperature measurement with a resolution of 0.5K. This work may have important prospects in flexible wearable physical sensors and individualized medical care.
Multiplex profiling of inflammation-related bioactive lipid mediators in Toxocara canis- and Toxocara cati-induced neurotoxocarosis

Background Somatic migration of Toxocara canis- and T. cati-larvae in humans may cause neurotoxocarosis (NT) when larvae accumulate and persist in the central nervous system (CNS). Host- or parasite-induced immunoregulatory processes contribute to the pathogenesis; however, detailed data on involvement of bioactive lipid mediators, e.g. oxylipins or eico-/docosanoids, which are involved in the complex molecular signalling network during infection and inflammation, are lacking. Methodology/Principal findings To elucidate if T. canis- and T. cati-induced NT affects the homeostasis of oxylipins during the course of infection, a comprehensive lipidomic profiling in brains (cerebra and cerebella) of experimentally infected C57BL/6J mice was conducted at six different time points post infection (pi) by liquid-chromatography coupled to electrospray tandem mass spectrometry (LC-ESI-MS/MS). Only minor changes were detected regarding pro-inflammatory prostaglandins (cyclooxygenase pathway). In contrast, a significant increase of metabolites resulting from lipoxygenase pathways was observed for both infection groups and brain regions, implicating a predominantly anti-inflammatory driven immune response. This observation was supported by a significantly increased 13-hydroxyoctadecadienoic acid (HODE)/9-HODE ratio during the subacute phase of infection, indicating an anti-inflammatory response to neuroinfection. Except for the specialised pro-resolving mediator (SPM) neuroprotectin D1 (NPD1), which was detected in mice infected with both pathogens during the subacute phase of infection, no other SPMs were detected. Conclusions/Significance The obtained results demonstrate the influence of Toxocara spp. on oxylipins as part of the immune response of the paratenic hosts. Furthermore, this study shows differences in the alteration of the oxylipin composition between T. canis- and T. cati-brain infection. Results contribute to a further understanding of the largely unknown pathogenesis and mechanisms of host-parasite interactions during NT.
Reconstruction of pediatric hand injuries caused by automatic cup-sealing machines in Taiwan

Objective This study was performed to share our clinical experience and provide treatment strategies for pediatric hand injuries caused by automatic cup-sealing machines in Taiwan. Methods Thirteen pediatric patients with an average age of 3.6 years were included in this retrospective study. Treatment was based on the location and depth of the injury and included full-thickness skin grafts, free or local flaps, and digital replantation. Some patients underwent contracture release during follow-up. Results Thermal crush injuries affected the left hand in five patients and right hand in eight. Four patients with nine amputated fingers were treated by emergent digital replantation, four were treated by skin grafting, one was treated by nail bed repair, one underwent reconstruction with a local reversed dorsal digital and metacarpal island flap, one underwent reconstruction with a fascia graft for extensor tendon repair and pedicled groin flap coverage, and two underwent reconstruction with free anterolateral thigh fasciocutaneous flaps with a vascularized fascia lata graft for dorsal hand defects. All replanted fingers survived. Conclusion Pediatric hand injuries, especially those caused by cup-sealing machines, can be devastating. Aggressive treatments including early reconstruction and rehabilitation should be performed for all pediatric hand injuries to achieve satisfactory functional restoration.
Phosphorylation of Gephyrin in Zebrafish Mauthner Cells Governs Glycine Receptor Clustering and Behavioral Desensitization to Sound

The process by which future behavioral responses are shaped by past experiences is one of the central questions in neuroscience. To gain insight into this process at the molecular and cellular levels, we have applied zebrafish larvae to explore behavioral desensitization to sound. A sudden loud noise often evokes a defensive response known as the acoustic startle response (ASR), which is triggered by firing Mauthner cells in teleosts and amphibians. The probability of evoking ASR by suprathreshold sound is reduced after exposure to repetitive auditory stimuli insufficient in amplitude to evoke the ASR (subthreshold). Although it has been suggested that the potentiation of inhibitory glycinergic inputs into Mauthner cell is involved in this desensitization of the ASR, the molecular basis for the potentiation of glycinergic transmission has been unclear. Through the in vivo monitoring of fluorescently-tagged glycine receptors (GlyRs), we here showed that behavioral desensitization to sound in zebrafish is governed by GlyR clustering in Mauthner cells. We further revealed that CaMKII-dependent phosphorylation of the scaffolding protein gephyrin at serine 325 promoted the synaptic accumulation of GlyR on Mauthner neurons through the enhancement of the gephyrin-GlyR binding, which was indispensable for and could induce desensitization of the ASR. Our study demonstrates an essential molecular and cellular basis of sound-induced receptor dynamics and thus of behavioral desensitization to sound. SIGNIFICANCE STATEMENT Behavioral desensitization in the acoustic startle response of fish is known to involve the potentiation of inhibitory glycinergic input to the Mauthner cell, which is a command neuron for the acoustic startle response. However, the molecular and cellular basis for this potentiation has been unknown. Here we show that an increase in glycine receptor (GlyR) clustering at synaptic sites on zebrafish Mauthner cells is indispensable for and could induce desensitization. Furthermore, we demonstrate that CaMKII-mediated phosphorylation of the scaffolding protein gephyrin promotes GlyR clustering by increasing the binding between the β-loop of GlyRs and gephyrin. Thus, the phosphorylation of gephyrin is a key event which accounts for the potentiation of inhibitory glycinergic inputs observed during sound-evoked behavioral desensitization.
The making of professors: Assessment and recognition in academic recruitment

How do academics become professors? This paper considers the making of ‘professor’ as a subject position through which academics are acknowledged in both organizational contexts and disciplinary fields. The paper examines social processes of recognition in 145 appointment procedures for professorships in the discipline of history at sixteen German universities between 1950 and 1985. Based on an analysis of over 1500 documents from archived appointment records, I investigate how academics are acknowledged as professorial in appointment procedures. The procedures invoked both (1) processes of judgement, in which worth and qualities are attributed to candidates, and (2) processes of legitimation, in which said judgements are stabilized and made acceptable. Using insights from the sociology of valuation and evaluation, this paper sheds light on the fundamental processes of recognition and valorization in academia. The findings contribute to the sociology of scientific knowledge and science and technology studies, which have concentrated on academic recognition in the realm of research, but paid less attention to such recognition in organizational contexts. Complementing this literature, the paper allows for a more general understanding of ‘professor’ as a focal academic subject position.
Multispecies biofilm formation by the contaminating microbiota in raw milk

Abstract Biofilms can be formed on the surfaces of dairy processing equipment and are a potential source of product contamination. This study evaluated the diversity of multispecies biofilms formed on stainless steel (SS) due to the contaminating microbiota in raw milk. Samples of raw milk were used: one was fresh milk and the other maintained in refrigerated bulk tanks for up to 48 h. The mesophilic aerobic contamination was ∼104 CFU ml−1 in fresh milk and 106 CFU ml−1 in bulk milk. SS coupons were kept immersed in the milk at 7 ±2 °C for 10 days, and every two days, the raw milk was changed for samples of the same origin collected on the current day. After incubation for 10 days, sessile cells in the biofilm reached 105 CFU cm−2 in the presence of fresh milk, and 106 CFU cm−2 in the presence of bulk milk. The genetic diversity analysis showed that Gammaproteobacteria and Bacilli predominated in the biofilms throughout the incubation of both milk samples and these biofilms showed a reduction in diversity over time. The main classes of bacteria found in these biofilms have representatives of great importance since many of them have spoilage potential.
The Medial Olivocochlear Reflex Is Unlikely to Play a Role in Listening Difficulties in Children

The medial olivocochlear reflex (MOCR) has been implicated in several auditory processes. The putative role of the MOCR in improving speech perception in noise is particularly relevant for children who complain of listening difficulties (LiD). The hypothesis that the MOCR may be impaired in individuals with LiD or auditory processing disorder has led to several investigations but without consensus. In two related studies, we compared the MOCR functioning of children with LiD and typically developing (TD) children in the same age range (7–17 years). In Study 1, we investigated ipsilateral, contralateral, and bilateral MOCR using forward-masked click-evoked otoacoustic emissions (CEOAEs; n = 17 TD, 17 LiD). In Study 2, we employed three OAE types: CEOAEs (n = 16 TD, 21 LiD), stimulus frequency OAEs (n = 21 TD, 30 LiD), and distortion product OAEs (n = 17 TD, 22 LiD) in a contralateral noise paradigm. Results from both studies suggest that the MOCR functioning is not significantly different between the two groups. Some likely reasons for differences in findings among published studies could stem from the lack of strict data quality measures (e.g., high signal-to-noise ratio, control for the middle ear muscle reflex) that were enforced in the present study. The inherent variability of the MOCR, the subpar reliability of current MOCR methods, and the heterogeneity in auditory processing deficits that underlie auditory processing disorder make detecting clinically relevant differences in MOCR function impractical using current methods.
parkrun: increasing physical activity in primary care.

Increasing physical activity among the general population is a priority in the prevention and treatment of disease and ongoing disease. Primary care is well placed to promote physical activity among sedentary adults. General practice provides over 300 million patient consultations each year,1 and primary healthcare teams play a key role in encouraging patients to make positive changes to their existing physical activity levels. Substantial numbers of these consultations take place with patients who could be helped by increasing their physical activity. Prevention as a priority runs throughout The NHS Long Term Plan , and emphasises the need to expand social prescribing.2 Physical activity initiatives and exercise referral schemes are a form of social prescribing that have the potential to improve patient health and wellbeing. However, many such schemes are often limited in availability and duration, which may limit their success at establishing longer-term changes to physical activity behaviours.3 parkrun is a series of free, weekly 5k events for all ages every Saturday morning, in areas of open space across the UK, as well as in over 20 countries globally. The organisation also delivers junior parkruns, which are 2k events for 4–14-year-olds and their families on a Sunday morning. The concept is simple: participants can walk, run, jog, spectate, or volunteer, meaning it is open to all, including those who are inactive or have health conditions or disabilities. There are no joining fees, no restrictions of a time-limited programme, no intimidating equipment. Just yourself, some comfy clothes and shoes, and a willingness to join in! parkrun enables participants to automatically become part of a supportive community. Once signed up, participants can opt …
The effect of the use of a decision aid with individual risk estimation on the mode of delivery after a caesarean section: A prospective cohort study

Objective After one previous caesarean section (CS), pregnant women can deliver by elective repeat CS or have a trial of labor which can end in a vaginal birth after caesarean (VBAC) or an unplanned CS. Despite guidelines describing women’s rights to make an informed choice, trial of labor and VBAC rates vary greatly worldwide. Many women are inadequately informed due to caregivers’ fear of an increase in CS rates in a high VBAC rate setting. We compared counseling with a decision aid (DA) including a prediction model on VBAC to care as usual. We hypothesize that counselling with the DA does not decrease VBAC rates. In addition, we aimed to study the effects on unplanned CS rate, patient involvement in decision-making and elective repeat CS rates. Methods We performed a prospective cohort study. From 2012 to 2014, 483 women in six hospitals, where the DA was used (intervention group), were compared with 441 women in six matched hospitals (control group). Women with one previous CS, pregnant of a singleton in cephalic presentation, delivering after 37 weeks 0 days were eligible for inclusion. Results There was no significant difference in VBAC rates between the intervention (45%) and control group (46%) (adjusted odds ratio 0,92 (95% Confidence interval 0.69–1.23)). In the intervention group more women (42%) chose an elective repeat CS compared to the control group (31%) (adjusted odds ratio 1.6 (95% Confidence interval 1.18–2.17)). Of women choosing trial of labor, in the intervention group 77% delivered vaginally compared to 67% in the control group, resulting in an unplanned CS adjusted odds ratio of 0,57 (0.40–0.82) in the intervention group. In the intervention group, more women reported to be involved in decision-making (98% vs. 68%, P< 0.001). Conclusions Implementing a decision aid with a prediction model for risk selection suggests unchanged VBAC rates, but 40% reduction in unplanned CS rates, increase in elective repeat CS and improved patient involvement in decision-making.
Recurrent Poisson Factorization for Temporal Recommendation

Poisson Factorization (PF) is the gold standard framework for recommendation systems with implicit feedback whose variants show state-of-the-art performance on real-world recommendation tasks. However, they do not explicitly take into account the temporal behavior of users which is essential to recommend the right item to the right user at the right time. In this paper, we introduce Recurrent Poisson Factorization (RPF) framework that generalizes the classical PF methods by utilizing a Poisson process for modeling the implicit feedback. RPF treats time as a natural constituent of the model, and takes important factors for recommendation into consideration to provide a rich family of time-sensitive factorization models. They include Hierarchical RPF that captures the consumption heterogeneity among users and items, Dynamic RPF that handles dynamic user preferences and item specifications, Social RPF that models the social-aspect of product adoption, Item-Item RPF that considers the inter-item correlations, and eXtended Item-Item RPF that utilizes items’ metadata to better infer the correlation among engagement patterns of users with items. We also develop an efficient variational algorithm for approximate inference that scales up to massive datasets. We demonstrate RPF's superior performance over many state-of-the-art methods on synthetic dataset, and wide variety of large scale real-world datasets.
Development and validation of multivariable clinical diagnostic models to identify type 1 diabetes requiring rapid insulin therapy in adults aged 18–50 years

Objective To develop and validate multivariable clinical diagnostic models to assist distinguishing between type 1 and type 2 diabetes in adults aged 18–50. Design Multivariable logistic regression analysis was used to develop classification models integrating five pre-specified predictor variables, including clinical features (age of diagnosis, body mass index) and clinical biomarkers (GADA and Islet Antigen 2 islet autoantibodies, Type 1 Diabetes Genetic Risk Score), to identify type 1 diabetes with rapid insulin requirement using data from existing cohorts. Setting UK cohorts recruited from primary and secondary care. Participants 1352 (model development) and 582 (external validation) participants diagnosed with diabetes between the age of 18 and 50 years of white European origin. Main outcome measures Type 1 diabetes was defined by rapid insulin requirement (within 3 years of diagnosis) and severe endogenous insulin deficiency (C-peptide <200 pmol/L). Type 2 diabetes was defined by either a lack of rapid insulin requirement or, where insulin treated within 3 years, retained endogenous insulin secretion (C-peptide >600 pmol/L at ≥5 years diabetes duration). Model performance was assessed using area under the receiver operating characteristic curve (ROC AUC), and internal and external validation. Results Type 1 diabetes was present in 13% of participants in the development cohort. All five predictor variables were discriminative and independent predictors of type 1 diabetes (p<0.001 for all) with individual ROC AUC ranging from 0.82 to 0.85. Model performance was high: ROC AUC range 0.90 (95% CI 0.88 to 0.93) (clinical features only) to 0.97 (95% CI 0.96 to 0.98) (all predictors) with low prediction error. Results were consistent in external validation (clinical features and GADA ROC AUC 0.93 (0.90 to 0.96)). Conclusions Clinical diagnostic models integrating clinical features with biomarkers have high accuracy for identifying type 1 diabetes with rapid insulin requirement, and could assist clinicians and researchers in accurately identifying patients with type 1 diabetes.