Miracle-dz/UniFAR-FTUs huggingface dataset:
An Industrial Intelligent Autonomous Recycling System using a Deep Learning Approach

—In this paper, an industrial intelligent autonomous recycling system is proposed for sorting recycling objects according to their own materials using deep learning. In order to adapt the system to be used in the real environment, movable robotic arm equipped with multifunctional grasping tool and mobile platform are integrated. The system structure is composed of four functionalities that are 1) object perception, 2) object clas-siﬁcation, 3) motion planning, and 4) navigation. To demonstrate the viability of the system, results for grasping, classiﬁcation, and navigation are evaluated in the new industrial platform.
Innate Immune Responses in NF- (cid:2) B-Repressing Factor-Deﬁcient Mice

NF- (cid:1) B-repressing factor (NRF) is a transcriptional silencer protein that speciﬁcally counteracts the basal activity of several NF- (cid:1) B-dependent promoters by direct binding to speciﬁc neighboring DNA sequences. In cell culture experiments, the reduction of NRF mRNA leads to a derepression of beta interferon, interleukin-8, and inducible nitric oxide synthase transcription. The X chromosome-located single-copy NRF gene is ubiquitously expressed and encodes a protein of 690 amino acids. The N-terminal part contains a nuclear localization signal, the DNA-binding domain, and the NF- (cid:1) B-repressing domain, while the C-terminal part is responsible for double-stranded RNA binding and nucleolar localization. To study the function of NRF in a systemic context, transgenic mice lacking the NRF gene were created. Against predictions from in vitro experiments, mice with a deletion
SLEEP APNEA AND FREE FATTY ACIDS IN SUBJECTS WITH HEART FAILURE effects of Sleep Apnea on Nocturnal Free Fatty Acids in Subjects with Heart Failure is common in patients with

Sleep congestive heart failure, and may contribute to the progression of underlying heart disease. Cardiovascular and metabolic complications of sleep apnea have been attributed to intermittent hypoxia. elevated free fatty acids (FFA) are also associated with the progression of metabolic, vascular, and cardiac dysfunction. The objective of this study was to determine the effect of intermittent hypoxia on FFA levels during sleep in patients with heart failure. Design and Interventions: during sleep, frequent blood samples were examined for FFA in patients with stable heart failure (ejection fraction < 40%). in patients with severe sleep apnea (apnea-hypopnea index = 65.5 ± 9.1 events/h; average low Spo 2 = 88.9%), FFA levels were compared to controls with milder sleep apnea (apnea-hypopnea index = 15.4 ± 3.7 events/h; average low Spo 2 = 93.6%). in patients with severe sleep apnea, supplemental oxygen at 2-4 liters/min was administered on a subsequent night to eliminate hypoxemia. Measurements and Results: prior to sleep onset, controls and patients with severe apnea exhibited a similar FFA level. After sleep onset, patients with severe sleep apnea exhibited a marked and rapid increase in FFA relative to control subjects. This increase persisted throughout NReM and ReM sleep exceeding serum FFA levels in control subjects by 0.134 mmol/l (p = 0.0038). Supplemental oxygen normalized the FFA profile without affecting sleep architecture or respiratory arousal frequency. Conclusion: in patients with heart failure, severe sleep apnea causes surges in nocturnal FFA that may contribute to the accelerated progression of underlying heart disease. Supplemental oxygen prevents the FFA elevation.
Almost global finite‐time stabilization of rigid body attitude dynamics using rotation matrices

This work considers continuous finite‐time stabilization of rigid body attitude dynamics using a coordinate‐free representation of attitude on the Lie group of rigid body rotations in three dimensions, SO(3). Using a Hölder continuous Morse–Lyapunov function, a finite‐time feedback stabilization scheme for rigid body attitude motion to a desired attitude with continuous state feedback is obtained. Attitude feedback control with finite‐time convergence has been considered in the past using the unit quaternion representation. However, it is known that the unit quaternion representation of attitude is ambiguous, with two antipodal unit quaternions representing a single rigid body attitude. Continuous feedback control using unit quaternions may therefore lead to the unstable unwinding phenomenon if this ambiguity is not resolved in the control design, and this has adverse effects on actuators, settling time, and control effort expended. The feedback control law designed here leads to almost global finite‐time stabilization of the attitude motion of a rigid body with Hölder continuous feedback to the desired attitude. As a result, this control scheme avoids chattering in the presence of measurement noise, does not excite unmodeled high‐frequency structural dynamics, and can be implemented with actuators that can only provide continuous control inputs. Numerical simulation results for a spacecraft in low Earth orbit, obtained using a Lie group variational integrator, confirm the theoretically obtained stability and robustness properties of this attitude feedback stabilization scheme. Copyright © 2015 John Wiley & Sons, Ltd.
DDDT_A_297500 1653..1666

*These authors contributed equally to this work Background: Pulmonary arterial hypertension (PAH) is an incurable disease that urgently needs therapeutic approaches. Based on the therapeutic effects of fasudil and dichloroacetate (DCA) on PAH, we aimed to explore the effects and potential mechanism of a new salt, fasudil dichloroacetate (FDCA), in a SU5416 plus hypoxia (SuHx)-induced rat model of PAH. Methods: The rat model of PAH was established by a single subcutaneous injection of SU5416 (20 mg/kg) followed by hypoxia (10% O2) exposure for 3 weeks. FDCA (15, 45, or 135 mg/kg i.g. daily) or the positive control, bosentan (100 mg/kg i.g. daily), were administered from the first day after SU5416 injection. After 3-week hypoxia, hemodynamic parameters, and histological changes of the pulmonary arterial vessels and right ventricle (RV) were assessed. Additionally, in vitro, the effects of FDCA (50 μM), compared with equimolar doses of fasudil, DCA, or fasudil+DCA, on the proliferation, migration, and contraction of human pulmonary arterial smooth muscle cell (PASMC) under hypoxia (1% O2) were evaluated. Results: FDCA dose-dependently attenuated SuHx-induced PAH, with significant reductions in RV systolic pressure, pulmonary artery wall thickness, pulmonary vessel muscularization, perivascular fibrosis, as well as RV hypertrophy and fibrosis. In vitro, FDCA inhibited hypoxia-induced PASMC proliferation, migration, and contraction to a greater degree than fasudil or DCA alone by restoring mitochondrial function, reducing intracellular Ca, and inhibiting calcium/calmodulin-dependent kinase (Ca/CaMK) activity as well as Rho-kinase activity. Conclusion: FDCA ameliorates hypoxia-induced PASMC dysfunction by inhibiting both Ca/CaMK and Rho-kinase signaling pathways, as well as maintaining mitochondrial homeostasis, thus alleviating SuHx-induced PAH.
Morphometry of human superﬁcial dorsal and dorsolateral column ﬁbres: signiﬁcance to spinal cord stimulation

in DC 0–300 and 114 (2%) in DLC 0–300 . Considering that the effect of SCS is primarily attributed to activation of these largest ﬁbres, it is concluded that a surprisingly small average amount of 2.4 ﬁbres per running 0.1 mm width and 6 ﬁbres per segmental division of the DC is involved. Distinct mediolateral heterogeneity in ﬁbre composition was found in both DC 0–300 and DLC 0–300 . In the DC 0–300 , the mean diameter of ﬁbres > 7.1 m m increases signiﬁcantly by 5% from medial to lateral. Density (i.e. number of ﬁbres per 1000 m m 2 ) and frequency (i.e. percentage of a ﬁbre size group compared to its parent population) of the large ﬁbres increase signiﬁcantly from medial to lateral in the DC 0–300 . For ﬁbres > 10.7 m m, these parameters increase by 200 and 269%, respect-ively. It is concluded that the difference in stimulation threshold of large A b ﬁbres in the median and lateral DC can be mainly attributed to the absence and presence, respectively, of collaterals at the stimulation site. Marked differences were found between DC 0–300 and DLC 0–300 . The largest DLC 0–300 ﬁbres ( > 10.7 m m) have a 320% higher frequency and a 473% higher density. Their mean diameter is, however, only 2% larger. The largest DLC 0–300 ﬁbres are not likely to be recruited by SCS, since they are not larger than their DC 0–300 counterparts, they lack collaterals (which would reduce the threshold stimulus substantially) and they are more remote from the stimulation electrode.
Cell Involvement T d g with no Evidence of Natural Priming or Primary, T Cell-Dependent IgG Response Response to Mycobacterial Hsp70: A Characteristics of the Strong Antibody

Despite its high degree of evolutionary conservation, hsp70 is a surprisingly robust Ag, to such a degree that it is under consid-eration as a potential substrate in vaccine development. The cellular basis of the strong humoral response, however, is unknown, although it is often hypothesized to derive from restimulation of memory T cells that have been primed by hsp of intestinal ﬂora. In this study, we tested this hypothesis and performed additional studies on the immune response to hsp70 of Mycobacterium tuberculosis. Superﬁcially, the primary Ab response to this protein resembles a T cell-dependent secondary one, constituted almost exclusively by IgG. However, there is no evidence of natural priming, as revealed both by in vitro stimulation experiments and by immunity in germfree mice. Although hsp70 stimulates gd and ab T cells from unprimed mice to proliferate in vitro, gd cells are not required for the strong humoral response, which is indistinguishable in normal and gd T cell-deﬁcient mice. Thus, the unusual immunogenicity of this protein in eliciting a humoral response appears to be due to a strong ab T cell response with no evidence of natural priming or a gd T cell involvement. The Journal of Immunology, 1998, 161: 5210–5216.
C OR D IAL : C OARSE - TO - FINE A BSTRACTIVE D I - ALOGUE S UMMARIZATION WITH C ONTROLLABLE G RANULARITY

Dialogue summarization is challenging due to its multi-speaker standpoints, casual spoken language style, and limited labeled data. In this paper, we propose C OR D IAL , aiming to improve the abstractive dialogue summarization quality and, at the same time, enable granularity controllability. We propose 1) a coarse-to-ﬁne generation strategy that generates a summary draft followed by a ﬁnal sum-mary. The summary draft, which provides weakly-supervised signals, comprises pseudo-labeled interrogative pronoun categories and noisy key phrases extracted with a constituency parser. 2) A simple strategy to control the granularity of the ﬁnal summary. C OR D IAL can automatically determine or control the number of generated summary sentences for a given dialogue by predicting and highlighting different text spans from the source text. Our model achieves state-of-the-art performance on the largest dialogue summarization corpus SAMSum. We conduct comprehensive case study and show competitive human evaluation results and controllability to human-annotated summaries.
Evidence Based for Improved Pharmacological Efficacy and Decreased Toxicity by Traditional Processing of Rhizoma Arisaematis in Mice

: Rhizoma Arisaematis (RA, the rhizome of Pinellia pedatisecta Schott) is a Traditional Chinese medicine commonly used for the management of convulsion, inflammation, and cancer. Despite being used for more than two thousand years, its pharmacological and toxicological effects by traditional processing products are still unclear. In this study, we attempted to investigate the neurobiological effects exerted by the different preparations of RA treated with either Alumen plus ginger juice (Zhinanxing) or with bile juice (Dannanxing) as compared with those of the untreated crude RA in ICR mice. The results showed that both the Zhinanxing and Dannanxing extracts exerted significantly more sedative effects as revealed by the inhibitory effects on ambulatory distances, jump, vertical-plan entries and prolonged pentobarbital-induced sleeping time as well as the analgesic property (increase of tail flick latency in the nociceptive testing) on mice than the unprocessed crude RA after oral administration for 1- to 3-days and after 18 days cessation of treatment. By contrast, the toxic effects such as the increase of stereotype-1 episodes of locomotor activities and reduction of the retention time on a rotating rod (motor equilibrium dysfunction) were found in mice only treated with unprocessed crude RA for 3 consecutive days, which were persistent after 18 days of cessation of administration. These neurotoxic effects were accompanied with an increase in plasma lipid peroxidation (LPO), decrease of whole blood nitric oxide (NO x ) levels, and inhibition of Na + /K + -ATPase activities on the membrane fractions of erythrocytes and cerebral cortex. In conclusion, these findings provide scientific evidence that the processed RA indeed possessed not only enhanced pharmacological efficacies but also reduced noxious effects as compared with the unprocessed crude RA. The signaling of NO/oxidative stress/Na + -K + -ATPase played a role, at least in part, in the underlying mechanisms of neurotoxic effects induced by the crude RA.
D 1 . 6 : Final topic modelling analysis

The main goal of this deliverable is to introduce an online tool that facilitates the exploration of key technological challenges and related policy issues. Based on a text-mining methodology, we examine and identify the specific topics discussed in a wide range of written media shared on social media platforms. The deliverable presents the results for six umbrella topics relevant to the NGI Forward project. To showcase the potential of the methodology, we also prepare a deep dive for the umbrella topic Access, Inclusion & Justice, focusing not only on challenges, but also on technology and policy solutions. The deliverable consists of three separate parts: a report summarising the results and policy insights; a paper providing the details of the methodology; and a website presenting the interactive results.
Identi cation of a 10-Gene Signature Model to Predict E cacy of Neoadjuvant Therapy in Patients With HER2 Positive Breast Cancer

Yusong Wang The First ,A liated Hospital of China Medical University Mozhi Wang The First A liated Hospital of China Medical University Xiangyu Sun The First A liated Hospital of China Medical University Litong Yao The First A liated Hospital of China Medical University Mengshen Wang The First A liated Hospital of China Medical University Haoran Dong The First A liated Hospital of China Medical University Xinyan Li The First A liated Hospital of China Medical University Mingcong He China Medical University Yingying Xu (  xuyingying@cmu.edu.cn ) the First A liated Hospital of China Medical University https://orcid.org/0000-0003-0023-6841
Bulky “Gatekeeper” Residue Changes the Cosubstrate Speciﬁcity of Aminoglycoside 2 (cid:1) -Phosphotransferase IIa

The aminoglycoside 2 (cid:1) -phosphotransferases APH(2 (cid:1) )-IIa and APH(2 (cid:1) )-IVa can utilize ATP and GTP as cosubstrates, since both enzymes possess overlapping but discrete structural templates for ATP and GTP binding. APH(2 (cid:1) )-IIIa uses GTP exclusively, because its ATP-binding template is blocked by a bulky tyrosine “gatekeeper” residue. Replacement of the “gatekeeper” residues M85 and F95 in APH(2 (cid:1) )-IIa and APH(2 (cid:1) )-IVa, respectively, by tyrosine does not signiﬁcantly change the antibiotic susceptibility proﬁles produced by the enzymes. In APH(2 (cid:1) )-IIa, M85Y substitution results in an (cid:1) 10-fold decrease in the K m value of GTP and an (cid:1) 320-fold increase in the K m value of ATP. In APH(2 (cid:1) )-IVa, F95Y substitution results in a modest decrease in the K m values of both GTP and ATP. Structural analysis indicates that in the APH(2 (cid:1) )-IIa M85Y mutant, tyrosine blocks access of ATP to the cor-rect position in the binding site, while the larger nucleoside triphosphate (NTP)-binding pocket of the APH(2 (cid:1) )-IVa F95Y mutant allows the tyrosine to move away, thus giving access to the ATP-binding template. broth MICs antimicrobials Mueller-Hinton II bacterial CFU/ml. The MIC measurements performed in To study the of
Stratified primary care for musculoskeletal consultations compared with usual care: study protocol for the STarT MSK cluster randomized controlled trial.

Background: Musculoskeletal (MSK) pain from common conditions such as back pain and osteoarthritis is a major cause of pain and disability. We previously developed a prognostic tool (STarT Back Tool) specifically for use in primary care to guide the management of patients with low back pain. Prognostic stratified care models involve matching treatments to the patient’s prognostic profile to support clinical decision-making in an effort to maximize treatment benefits, reduce harm and increase health care efficiency. A logical next step is to determine whether a similar model of prognostic stratified care might also have benefits for primary care patients with a much broader range of MSK pain presentations (back, neck, knee, shoulder and multi-site pain). Objective: The primary objective is to determine, in patients presenting with one of the five most common MSK pain presentations in UK primary care, whether stratified care involving use of the Keele STarT MSK Tool to allocate individuals into low, medium and high risk subgroups and matching these subgroups to recommended matched clinical management options, is more clinically and cost effective compared to usual non-stratified primary care. Methods: We are conducting a pragmatic, two parallel-arm (stratified versus non-stratified care), cluster RCT, with a linked health economic analysis and mixed methods process evaluation.
TRANSPLANTATION The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation

We examined the impact of intestinal diversity on subsequent mortality outcomes following transplantation. Fecal specimens were collected from 80 recipients of allo-HSCT at the time of stem cell engraftment. Bacterial 16S rRNA gene sequences were characterized, and microbial diversity was estimated using the inverse Simpson index. Subjects were classified into high, intermediate, and low diversity groups and assessed for differences in outcomes. Mortality outcomesweresignificantlyworseinpatientswithlowerintestinaldiversity;overallsurvivalat3yearswas36%,60%,and67%forlow, intermediate, and high diversity groups, respectively ( P 5 .019, log-rank test). Low diversity showed a strong effect on mortality after multivariateadjustmentforotherclinicalpredictors(transplantrelatedmortality:adjustedhazardratio,5.25; P 5 .014). Inconclusion, thediversityoftheintestinalmicrobiotaatengraftmentisanindependentpredictorofmortalityinallo-HSCTrecipients.Theseresults indicatethattheintestinalmicrobiotamaybeanimportantfactorinthesuccessorfailureinallo-HSCT. ( Blood .2014;124(7):1174-1182)
I SLAMIC R ELIGIOUS E DUCATION IN THE A RCHIPELAGO : A S TUDY OF D OCTORAL P ROGRAM C URRICULUM

This article analyzes the developing curriculum content of Islamic education in doctoral programs in the archipelago as a response to changes in the academic and social cultural community. This study is formed using qualitative research with content analysis as a data analysis technique. The primary sources are the official websites of three doctoral programs: Doctoral Programs of Interdisciplinary Studies-Based Islamic Education of Universitas Islam Negeri (UIN) Maulana Malik Ibrahim, Islamic Education of Universitas Muhammadiyah Malang (UMM), and Multicultural Islamic Education of Universitas Islam Malang (UNISMA). The findings of this study reveal that the developing curriculums denote the vision and mission of the respective programs and the prevailing sociological progress within the society. The current doctoral programs on Islamic Education attempt to adjust to the needs of the nation and state by including Islamic and multidisciplinary content within their curriculums. In addition, they also convey scientific methods and critical thinking, the development of educational sciences, and preparation of dissertations. These doctoral program curriculums produce the best graduates that excel in multidisciplinary scientific fields and provide multicultural national insight in their areas.
High-Speed On-Chip Signaling: Voltage or Current-Mode?

In this paper, we investigate several on-chip signaling schemes. Specifically, we compare different voltage-mode (VM) and current-mode (CM) signaling schemes considering power, performance, and robustness. In addition, we propose a new CM signaling scheme that uses a simple NAND-NOR gate transmitter circuit and a current-comparator-based receiver circuit. We implemented each signaling scheme using a 45 nm CMOS technology. The extracted simulation results show that a traditional CM signaling scheme consumes 58–78% less power compared to a traditional buffered VM signaling scheme in the 1–3 GHz frequency range. Our proposed CM signaling scheme consumes up to 95% and 81% lower power compared to buffered VM and existing CM schemes, respectively. In addition, the proposed CM signaling scheme has 37–41% lower latency with similar slew-rates compared to the buffered signaling scheme.
glycol 1000 succinate nanoparticles for the targeted treatment of liver cancer

INTRODUCTION PLGA-TPGS (MW 21 000-22 000) was prepared by Dr Lin Mei, who works at Academy of Life Sciences, Tsinghua University (Beijing, China), and H-NMR spectrum of copolymer PLGA-TPGS have been provided in this paper. PLGA-TPGS random copolymer was synthesized from lactide, glycolide and TPGS by ring-opening polymerization using stannous octoate as catalyst. Briefly, weighted amounts of glycolide, lactide, TPGS and 0.5% stannous octoate (distilled toluene as solvent) were added in a reaction flask. The mixture was heated to 145 °C and allowed to react for 16 h. Synthesis was carried out under an oxygenand moisture-free environment. The resulting product was dissolved in dichloromethane (DCM) and then precipitated in excess cold methanol to remove unreacted monomers and TPGS. The final product was collected by filtration and dried under high vacuum at 45 °C for 48 h. H-NMR spectrum of PLGA-TPGS (seen in Fig. S1) as follows: The signals at 5.2 (peak a) and 1.69 ppm (peak d) were assigned to the -CH protons and methyl protons –CH3 of PLA segment, respectively. The peak at 3.65 ppm (peak c) was assigned to the –CH2 protons of PEO part of TPGS , and the peak at 4.82 (peak b) was assigned to the –CH2 of PGA (Ma et al., 2010; Chen et al., 2011). To avoid repeats, the synthetic process and H-NMR spectrum of PLGA-TPGS isn’t mentioned in this paper, as that can be found from our previous reports (Ma et al., 2010; Chen et al., 2011). In which the corresponding author Yan Tian was one of the authors, we have already put two papers as reference in our present paper.