Miracle-dz/UniFAR-FTUs huggingface dataset:
An E�cient Parallel Block Compressive Sensing Scheme for Medical Signals and Image Compression

— With rapid development of real-time and dynamic application, Compressive Sensing or Compressed sensing (CS) has been used for medical image and biomedical signal compression in the last decades. The performance of CS based compression is mostly dependent on decoding methods rather than the CS encoding methods used in practice. Many CS encoding and decoding algorithms have been reported in literature. However, the comparative study on performance metrics of CS encoding with block processing and without block processing is not investigated by the researchers so far. This paper proposes block CS based medical images and signals compression technique and the proposed technique is compared with standard CS compression. The proposed algorithm divides the input medical images and signals to blocks and each block is processed parallel to enable faster computation. Three performance indices, i.e., the peak signal to noise ratio (PSNR), reconstruction time (RT) and structural similarity index (SSIM) were tested to observe their changes with respect to compression ratio. The results showed that block CS algorithm had better performance than standard CS based compression. More specifically, the parallel block CS reported the best results than standard CS with respect to less reconstruction time and satisfactory PSNR and SSIM.
Functional Domains of the RhlR Transcriptional Regulator of Pseudomonas aeruginosa

The RhlR transcriptional regulator of Pseudomonas aeruginosa , along with its cognate autoinducer, N -butyryl homoserine lactone (C 4 -HSL), regulates gene expression in response to cell density. With an Escherichia coli LexA-based protein interaction system, we demonstrated that RhlR multimerized and that the degree of multimerization was dependent on the C 4 -HSL concentration. Studies with an E . coli lasB :: lacZ lysogen demonstrated that RhlR multimerization was necessary for it to function as a transcriptional activator. Deletion analysis of RhlR indicated that the N-terminal domain of the protein is necessary for C 4 -HSL binding. Single amino acid substitutions in the C-terminal domain of RhlR generated mutant RhlR proteins that had the ability to bind C 4 -HSL and multimerize but were unable to activate lasB expression, demonstrating that the C-terminal domain is important for target gene activation. Single amino acid substitutions in both the N-terminal and C-terminal domains of RhlR demonstrated that both domains possess residues involved in multimerization. RhlR with a C-terminal deletion and an RhlR site-speciﬁc mutant form that possessed multimerization but not transcriptional activation capabilities were able to inhibit the ability of wild-type RhlR to activate rhlA expression in P . aeruginosa . We conclude that C 4 -HSL binding is necessary for RhlR multimerization and that RhlR functions as a multimer in P . aeruginosa These conserved amino
T Cells in Melanoma + Melan-A-Specific CD8 Usage Reveals a Large Repertoire of -Chain b Tetramer-Guided Analysis of TCR

The assessment of the TCR repertoire expressed by tumor-speciﬁc CD8 1 T lymphocytes has been hampered to date by the difﬁculty of targeting the analysis to lymphocytes directed against a single epitope. In the present study we have used ﬂuorescent A2/Melan-A tetramers in conjunction with anti-CD8 and anti-TCR b -chain variable (BV) mAbs to analyze by ﬂow cytometry the BV segment usage by Melan-A-speciﬁc CD8 1 T cells in tumor-inﬁltrated lymph nodes (TILN) and tumor-inﬁltrating lymphocytes (TIL) from A2 melanoma patients. Analysis of TILN populations revealed small proportions of A2/Melan-A tetramer 1 cells expressing many different BV together with over-representation of A2/Melan-A tetramer 1 cells expressing certain BVs. The BV usage by A2/Melan-A tetramer 1 lymphocytes in TIL was more restricted than that in TILN. Moreover, the predominant BV segments were quite distinct in populations derived from different patients. A2/Melan-A tetramer 1 cells expressing the dominant BVs found in TILN could also be found in the corresponding peptide-stimulated autologous PBMC, although A2/Melan-A tetramer 1 lymphocytes expressing additional BVs were also identiﬁed. Together, these results suggest that a large and diverse repertoire of Melan-A-speciﬁc T cells using different BV TCR segments is available in A2 melanoma patients. The Journal of Immunology, 2000, 165: 533–538. Cancer, and human rIL-7 (10 ng/ml; R&D Systems Oxon, U.K.). were for 2 wk before A2/Melan-A tetramer-guided b -chain variable (BV) chain usage analysis.
Edinburgh Research Explorer Intercepting the Disilene-Silylsilylene Equilibrium

: The equilibrium between disilenes (R 2 Si=SiR 2 ) and their silylsilylene (R 3 Si-SiR) isomers has previously been inferred but not directly observed, except in the case of the parent system H 2 Si=SiH 2 . Here, we report a new method to prepare base-coordinated disilenes with hydride substituents. By varying the bulk of the coordinating base and other silicon substituents, we have been able to control the rearrangement of disilene adducts to their silylsilylene tautomers. Remarkably, 1,2 migration of a trimethylsilyl group is preferred over hydrogen migration. A DFT study of the reaction mechanism provides a rationale for the observed reactivity and detailed information on the bonding situation in base-stabilized disilenes. D Ar* Analogous isomerization of the Cp*-substituted disilene adduct A Cp* (cf. 3 ) to the corresponding silylsilylene adduct D Cp* , however, is kinetically inhibited (∆ ‡ G = 37 kcal mol –1 ) and endergonic by 4 kcal mol –1 . The greater stability of the silylsilylene base-adduct D Ar is a consequence of increased steric bulk in A Ar* . The isomerization of disilene, Si 2 H 4 , to its silylsilylene tautomer occurs readily. Stable disilenes with bulky substituents display reactivity that indicates the same rearrangement can occur, but experimental observations of the silylsilylene isomers are rare. We report base coordinated hydridodisilenes that rearrange to their silylsilylene isomers, together with a detailed mechanistic study of the transformation.
Operators of Fuchs type, conical singularities, and asymptotic methods

This text is a revised version of the authors Habilitationsschrift which was submitted to the University of Augsburg, 1993. Fuchs type differential operators are used to model the analysis on manifolds with cone--like singularities, or more general, stratified spaces. This book provides a self--contained treatment of the analysis of the heat equation and index theory for these operators. Major topics are short--time asymptotics, $\eta$-- and $\zeta$--functions, (relative) index theorems. Another chapter is devoted to the discussion of deficiency indices and Dirac Schr\"odinger operators.
Identiﬁcation of a Speciﬁc Isoform of Tomato Lipoxygenase (TomloxC) Involved in the Generation of Fatty Acid-Derived Flavor Compounds 1

There are at least ﬁve lipoxygenases (TomloxA, TomloxB, TomloxC, TomloxD, and TomloxE) present in tomato ( Lycopersicon esculentum Mill.) fruit, but their role in generation of fruit ﬂavor volatiles has been unclear. To assess the physiological role of TomloxC in the generation of volatile C6 aldehyde and alcohol ﬂavor compounds, we produced transgenic tomato plants with greatly reduced TomloxC using sense and antisense constructs under control of the cauliﬂower mosaic virus 35S promoter. The expression level of the TomloxC mRNA in some transgenic plants was selectively reduced by gene silencing or antisense inhibition to between 1% and 5% of the wild-type controls, but the expression levels of mRNAs for the four other isoforms were unaffected. The speciﬁc depletion of TomloxC in transgenic tomatoes led to a marked reduction in the levels of known ﬂavor volatiles, including hexanal, hexenal, and hexenol, to as little as 1.5% of those of wild-type controls following maceration of ripening fruit. Addition of linoleic or linolenic acid to fruit homogenates signiﬁcantly increased the levels of ﬂavor volatiles, but the increase with the TomloxC-depleted transgenic fruit extracts was much lower than with the wild-type control. Confocal imaging of tobacco ( Nicotiana tabacum ) leaf cells expressing a TomloxC-GFP fusion conﬁrmed a chloroplast localization of the protein. Together, these results suggest that TomloxC is a chloroplast-targeted lipoxygenase isoform that can use both linoleic and linolenic acids as substrates to generate volatile C6 ﬂavor compounds. The roles of the other lipoxygenase isoforms are discussed.
Effect of Solvent Extraction on Phytochemical Component and Antioxidant Activity of Vine and Rhizome Ampelocissus martini

Som Kung, locally known as wild grape, belongs to the Vitaceae family and its scientific name is Ampelocissus martini . Its leaf, root and bark are used in traditional Thai medicine for providing relief of symptoms. In this work we studied the phytochemical and antioxidant activities of the hexane, ethyl acetate and methanol crude extracts of vines and rhizomes of Ampelocissus martini . Qualitative analysis of the phytochemical screening of the various extracts revealed the presence of terpenoid, flavonoid, saponin, phenolic acid and alkaloid. Total phenolic and flavonoid contents were investigated by using Folin-Ciocalteu and colorimetric aluminum chloride assays, respectively. The results showed that the methanolic extract of vines and rhizomes gave significantly higher total phenolic and flavonoid contents than the ethyl acetate and hexane extracts. In addition, the methanolic and ethyl acetate extracts of both parts had higher antioxidant activities than their hexane extracts. Positive correlation coefficients were observed (r = 0.987) between total phenolic and flavonoid contents and also (r = 0.998) between DPPH and ABTS. The present study provides evidence that solvent extracts of A. martini contain important bioactive compounds, especially the methanol extract, which produced a number of phytochemical compounds. Further study will isolate and identify the active compounds of vines and rhizomes from this solvent
Layer-Speci c Intracortical Ampli cation Shortens the Lifetime of Thalamocortical Repetition Suppression in Auditory Cortex

Jing Ma Leibniz Institute for Neurobiology Michael Brunk Max Planck Institute of Microstructure Physics https://orcid.org/0000-0001-5854-1545 Artur Matysiak Leibniz Institute for Neurobiology Nina Härtwich Leibniz Institute for Neurobiology Frank Ohl Leibniz Institute for Neurobiology Patrick May Leibniz Institute for Neurobiology Max Happel Leibniz Institute for Neurobiology Reinhard König Leibniz Institute for Neurobiology Matthias Deliano (  Matthias.Deliano@lin-magdeburg.de ) Leibniz Institute for Neurobiology
Causal and Semantic Relations in Second Language Discourse Processing: An Eye-Tracking Study

This study investigated how causal and semantic relatedness between sentences affects second language discourse processing as reflected by eye movements. Japanese learners of English read two-sentence texts varying in causal and semantic relatedness and their eye movements were recorded. Linear mixed-effects models of eye movement measures revealed that causal relatedness has a robust impact on both fixation durations and lookback frequency, whereas the effects of semantic relatedness are modulated by causal relatedness and reading skill.
HUBBLE SPACE TELESCOPE MEASURES OF MASS ACCRETION RATES IN THE ORION NEBULA CLUSTER MEASURES OF MASS ACCRETION RATES IN THE ORION NEBULA

The present observational understanding of the evolution of the mass accretion rates ( ˙ M acc ) in pre-main-sequence stars is limited by the lack of accurate measurements of ˙ M acc over homogeneous and large statistical samples of young stars. Such observational effort is needed to properly constrain the theory of star formation and disk evolution. Based on Hubble Space Telescope / WFPC2 observations, we present a study of ˙ M acc for a sample of ∼ 700 sources in the Orion Nebula Cluster, ranging from the hydrogen-burning limit to M ∗ ∼ 2 M (cid:5) . We derive ˙ M acc from both the U -band excess and the H α luminosity ( L H α ), after determining empirically both the shape of the typical accretion spectrum across the Balmer jump and the relation between the accretion luminosity ( L acc ) and L H α , which is L acc /L (cid:5) = (1 . 31 ± 0 . 03) · L H α /L (cid:5) + (2.63 ± 0.13). Given our large statistical sample, we are able to accurately investigate relations between ˙ M acc and the parameters of the central star such as mass and age. We clearly ﬁnd ˙ M acc to increase with stellar mass and decrease over evolutionary time, but we also ﬁnd strong evidence that the decay of ˙ M acc with stellar age occurs over longer timescales for more massive PMS stars. Our best-ﬁt relation between these parameters is given by log( ˙ M acc /M (cid:5) yr) = ( − 5.12 ± 0.86) − (0.46 ± 0.13) · log( t/ yr) − (5.75 ± 1.47) · log( M ∗ /M (cid:5) ) + (1.17 ± 0.23) · log( t/ yr) · log( M ∗ /M (cid:5) ). These results also suggest that the similarity solution model could be revised for sources with M ∗ (cid:2) 0 . 5 M (cid:5) . Finally, we do not ﬁnd a clear trend indicating environmental effects on the accretion properties of the sources.
Molecular Biology of Ovarian Aromatase in Sex Reversal: Complementary DNA and 5 0 -Flanking Region Isolation and Differential Expression of Ovarian Aromatase in the

To elucidate the involvement of aromatase in sex reversal, the gilthead seabream ovarian P450 aromatase ( cyp19a1a ) cDNA and its 5 0 -flanking region were isolated and characterized. Northern blot analysis revealed that only one cyp19a1a transcript (2.0 kb) is expressed in the ovary. Four cAMP-responsive elements were identified at the 5 0 -flanking region of seabream cyp19a1a indicating a high potential to respond to gonadotropin signaling. Studying the seasonal profile, two expression peaks of cyp19a1a transcripts in the ovarian tissues were found in July (about 15000 copies/ng total RNA) for ambisexual fish and in December (about 12000 copies/ng total RNA) for spawning females. Starting from September, transcript levels of cyp19a1a in the ovarian portions of the male-developing gonads gradually decreased. Furthermore, the ovarian portions of the female gonads expressed cyp19a1a at a significantly higher level than the ovarian portions of the male gonads after November. Taken together with levels of plasma estradiol in reversing females being significantly higher than those in developing males, the above results reinforce the importance of cyp19a1a in sex reversal. In vitro exposure of ovarian fragments to gonadotropins (hCG) at 1, 10, and 100 IU/ ml significantly ( P , 0.05) upregulated cyp19a1a expression. Additionally, expression of cyp19a1a displayed a stronger and significant correlation with the transcript expression of ovarian Lh receptor rather than Fsh receptor during the ambisexual stage. Our results indicate that the differential expression of cyp19a1a gene is associated with sex reversal and that gonadotropin signals (particularly Lh) may serve as major players in regulating the expression of cyp19a1a during the process of sex reversal.
Primary In Vitro Stimulation ofMonoclonal CTL

The immune potential of an individual is determined by the receptor repertoire available to numerous interrelated lymphocyte subpopulations. Until recently, most research dealing with repertoire has been conducted in the B lymphocyte compartment. These studies have taken advantage of the fact that the immunoglobulin product of a B cell is idiotypically identical to the cell's receptor (1). Methods that have been used to distinguish immunoglobulins, and thereby define repertoire, including (a) amino acid sequence analysis, (b) fine specificity analysis or affinity of antibody, (c) reactivity with anti-idiotypic reagents, and (d) isoelectric focusing of antibodies (2). In contrast, because of the inaccessability of the T cell receptor, relatively little is known about the T cell repertoire. Conclusions regarding T lymphocyte receptor diversity have been largely based on the study of the specificity of antigenically stimulated populations of T cells. This approach has been applied to the study of most T cell subpopulations and is the basis of the belief that the receptors found on T cells exhibit a high degree of antigen specificity (3-5). This approach has also revealed several features that appear to be unique to T lymphocyte function. For example, in addition to antigen specificity, T cells are functionally restricted to H-2identical cells (6-10). Also, a high proportion of T cell precursors are activated by H2 alloantigens (11-16). It is not known to what extent these properties are reflected in the T cell receptor repertoire; however, they introduce the possibility of a profound effect of H-2 on repertoire selection, a feature not usually associated with the B cell repertoire (17-22). On the other hand, studies with anti-idiotypic reagents prepared against immunoglobulin idiotypes have revealed similarities between T and B cell receptors. B cell idiotypes have been demonstrated on a variety of different T cell subsets (23-29). Receptors on murine cytolytic T lymphocytes (CTL), 1 however, have not as yet been found to bear B cell-idiotypic determinants (30). Resolution of questions concerning the extent of sharing between the T and B cell compartment, as well as genetic or environmental determination of the T cell repertoire, require an experimental approach that could identify the entire T cell repertoire specific for a particular antigen. One approach that was proven useful in identification of the B cell repertoire is the application of panel analysis to the
DMSO_A_257797 2843..2853

Department of Nutritional Sciences, And Obesity Research Institute, Texas Tech University, Lubbock, TX 79424, USA Introduction: The renin angiotensin aldosterone system (RAAS) is a hormone system known for its role in regulating blood pressure and fluid balance. Numerous RAAS inhibitors routinely prescribed for hypertension have also beneficial effects in type 2 diabetes (T2D) prevention. RAAS components are expressed locally in many tissues, including adipose tissue and pancreas, where they exert metabolic effects through RAAS bioactive hormone angiotensin II (Ang II). Pancreatic beta cells are specialized insulin-producing cells; they have also developed endoplasmic reticulum (ER), which contributes to beta cell dysfunction, when proteins are misfolded in disease states such as T2D. However, no studies have investigated the relationship between RAAS and ER stress in beta cells as a mechanism linking pancreatic RAAS to T2D. Hence, we hypothesized that Ang II treatment of beta cells increases ER stress and inflammation leading to reduced insulin secretion. Methods: To test this hypothesis, we treated clonal INS-1E beta cells and human islets with Ang II and assessed changes in ER stress markers. INS-1E beta cells were also used for measuring insulin secretion and for assessing the effects of various RAAS and ER stress inhibitors. Results: We demonstrated that Ang II significantly increased the expression of ER stress genes such as Chop and Atf4 and reduced insulin secretion. Furthermore, inhibition of Ang II production with an angiotensin converting enzyme inhibitor (ACEi, captopril) significantly reduced ER stress. Moreover, the Ang II receptor blockade reduced ER stress significantly and rescued insulin secretion. Discussion: This research provides new mechanistic insight into the role of RAAS activation via ER stress on beta cell dysfunction and provides additional evidence for protective effects of RAAS inhibition in T2D.
International Journal of Science and Business

This paper explores the differences adduced in literature between the females and the males’ sexes regarding their aptitudes in executing impactful business strategies to effectively advance economic performance in Nigeria. Extant literature produced significant gender variant strategies regarding policies execution in meeting with organizational objectives. However, this was reviewed to validate the proposition that performance is not limited to gender but an integration of some identified five taxonomies implicit in strategy execution; the dimensions of rules, emotions, initiatives, immediate action and integrity. We further explored the frontiers of gender management by examining specific factors of various dimensions of strategy execution in the context of whether or not gender has an impact on economic performance. Remarkably, attempts were made to obviate the inclination on gender as inappropriate in determining performance to organizational practices. Literature indicated that both women and men seemed individually inspired by a blend of push and pull factors. This study proves its contribution by stating that despite the empirical evidences in male-female differences in problem-solving abilities, analytical skills, competitive drive, enthusiasm, civility, or learning abilities. An integration of a proportionate gender synthesis will function more effectively in the execution of a business stratagem. The modern society thinking is therefore eroding on the earlier boundaries set between life style and achievement of both sexes. IJSB Literature Review Accepted 24 April 2019 Published 25 April 2019 DOI: 10.5281/zenodo.2651083
Genetic Diversity and Structure in Japanese Populations of the Osprey ( Pandion haliaetus ), Based on mtDNA Cytochrome b, Control Region

Osprey is a type of bird of prey that lives almost all over the world. In Japan, it is designated as a near-threatened species because it has less than 1000 individuals. In recent years, it inhabits more inland than in coastal areas. In this study, we conducted a population genetic analysis focusing on what kind of genetic structure Japanese Osprey retains and whether there are differences between coastal and inland populations. We also performed genetic diversity assess-ments. We sequenced about 2.3 kb of mtDNA for 27 individuals in Japan, and phylogenetic analysis, network analysis, neutrality test and mismatch distribution analysis were performed. Eighteen haplotypes were detected in 27 individuals, indicating that genetic diversity was sufficiently high. Both unique and common haplotypes were detected between inland and coastal populations, suggesting gene flow between the two populations. Phylogenetic analysis results show no genetic differentiation in the Japanese Osprey population. From the results of network analysis, neutrality test and mismatch distribution analysis, it was inferred that the Japanese Osprey had a population expansion in the past. This study indicated that the dispersion of Japanese Osprey was random and there were no restrictions on the breeding area. The information presented here can be used towards implementing future conservation actions.