Miracle-dz/UniFAR-FTUs huggingface dataset:
Zinc Oxide Nanoparticles Induce Apoptosis in Human Breast Cancer Cells via Caspase-8 and P 53 Pathway

Nanoparticles are a special institution of substances with precise capabilities and significant applications in many biomedical fields. In the present work zinc oxide nanoparticles were prepared through sol-gel approach. The synthesised nanoparticles were identified through the usage of X-ray powder diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). In-vitro anticancer activity of zinc oxide nanoparticles towards MCF-7 cell lines using numerous parameters was investigated. Zinc oxide nanoparticles were determined to exert cell growth arrest against MCF-7 cell lines. The anti-proliferative efficiency of ZnO nanoparticles was due to cell dying and inducing apoptosis that were confirmed by the usage of acridine orange/ethidium bromide dual staining, DAPI staining and genotoxicity assay. Reverse transcription polymerase chain reaction (RTPCR) analysis achieved to identify the gene expression of Caspase-8, Caspase-9, and P53. The results suggested that ZnO nanoparticles might find a wide use in clinical applications and provide new drug recompense for chemotherapy drugs.
Internodal HER 2 heterogeneity of axillary lymph node metastases in breast cancer patients

Determination of human epidermal growth factor receptor 2 (HER2) status is important for adequate treatment of breast cancer (BC) patients. The novel HER2 gene protein assay (GPA) is particularly convenient, as it allows the simultaneous assessment of HER2 protein expression and gene amplification at individual cell level. Here we investigated the frequency of internodal HER2 heterogeneity in axillary lymph node macrometastases of BC patients and compared HER2 status between primary breast tumor and its metastases. We included a total of 41 female patients operated between 2014 and 2015 for primary BC with axillary lymph node macrometastases. Representative paraffin blocks of metastatic lymph nodes were sectioned and the slides were stained using the GPA in 38 BC cases. GPA results were assessed according to the ASCO/CAP 2013 criteria. We analyzed 12586 individual tumor cells, 120 cells per section of each metastatic lymph node. HER2 status differed between the primary tumor and its metastases in 5/38 cases (13.2%). In patients with at least two metastatic nodes, the HER2 status of lymph node metastases was only slightly different in 4/23 cases (17.4%). Our results indicate rare but substantial differences in HER2 status between primary breast tumor and its axillary lymph node metastases that may direct the choice and outcomes of targeted therapy in BC patients. The impact of the rare and subtle internodal HER2 heterogeneity evidenced in this study remains uncertain. Determining the HER2 status of lymph node metastases in BC seems to be rational, but assessing a limited number of metastatic nodes may be sufficient.
VECSEL systems for generation and manipulation of trapped magnesium ions

Experiments in atomic, molecular, and optical (AMO) physics rely on lasers at many different wavelengths and with varying requirements on spectral linewidth, power, and intensity stability. Vertical external-cavity surface-emitting lasers (VECSELs), when combined with nonlinear frequency conversion, can potentially replace many of the laser systems currently in use. Here we present and characterize VECSEL systems that can perform all laser-based tasks for quantum information processing experiments with trapped magnesium ions. For photoionization of neutral magnesium, 570.6 nm light is generated with an intracavity frequency-doubled VECSEL containing a lithium triborate (LBO) crystal for second harmonic generation. External frequency doubling produces 285.3 nm light for resonant interaction with the S0 ↔ P1 transition of neutral Mg. Using an externally frequency-quadrupled VECSEL, we implement Doppler cooling of 25Mg+ on the 279.6 nm S1/2 ↔ P3/2 cycling transition, repumping on the 280.4 nm S1/2 ↔ P1/2 transition, coherent state manipulation, and resolved sideband cooling close to the motional ground state. Our systems serve as prototypes for applications in AMO requiring single-frequency, power-scalable laser sources at multiple wavelengths.
Using semantic resources to improve a syntactic dependency parser

Probabilistic syntactic parsing has made rapid progress, but is reaching a performance ceiling. More semantic resources need to be included. We exploit a number of semantic resources to improve parsing accuracy of a dependency parser. We compare semantic lexica on this task, then we extend the back-off chain by punishing underspecified decisions. Further, a simple distributional semantics approach is tested. Selectional restrictions are employed to boost interpretations that are semantically plausible. We also show that self-training can improve parsing even without needing a re-ranker, as we can rely on a sufficiently good estimation of parsing accuracy. Parsing large amounts of data and using it in self-training allows us to learn world knowledge from the distribution of syntactic relation. We show that the performance of the parser considerably improves due to our extensions.
Life satisfaction and its contributors among noninstitutionalized older people in Tabriz , Islamic Republic of Iran PDF version

Background: With the rising growth of the older population, the well-being of the elderly is an important objective for both economic and health policy. Aims: This study investigates levels of life satisfaction among older people living at home and the factors that influence it. Method: Applying probability proportional to size, a cross-sectional survey was conducted of 1067 older people living in Tabriz. The Satisfaction with Life Scale and the Multidimensional Scale of Perceived Social Support questionnaires were administered. The data were analysed using chi-squared tests and logistic regression. Results: More than half of the participants were dissatisfied with their lives. Female, educated, and active older people reported greater satisfaction than others. Conclusion: The significant positive effects of perceived social support and physical activity rate indicated that social interaction may be as vital as physical activity for the well-being of older people, and that these qualities should be actively promoted among older people in Iran.
Stages of health behaviour change and planning : RCT of stage-specific effects of planning on dental

Stage theories of health behavior change assume qualitative differences between stages. To test this, individuals in the motivational (n = 56) and volitional (n = 32) stages were randomly assigned to a planning intervention or a control condition in a RCT on dental flossing with three measurement points over eight weeks. Planning is a validated post-intentional strategy for behavior change and is thus matched to volitional individuals decided to change and mismatched to motivational individuals not yet decided to change behavior. A repeated-measures ANOVA with stage and intervention group as factors revealed that stage moderated the effectiveness of planning. Besides a main effect of the intervention, volitional participants receiving the planning intervention outperformed motivational participants in the planning condition at both follow-up measurements. This implies that planning is a viable strategy to facilitate health behavior change and supports the idea of two qualitatively distinct stages of health behavior change.
Web-based information guide to promote application for medical rehabilitation : a randomized controlled trial

Objectives To investigate the effectiveness of web-based intervention to support claims for rehabilitation Methods Randomized controlled registerand survey-based trial (German Clinical Trials Register: DRKS00005658). The respondents were randomly allocated to receive a letter containing general information about medical rehabilitation alone (controls) or to an additional web-based intervention (cases). The primary outcome was the proportions of either applied and used medical rehabilitation services after 1 year as extracted from administrative data records and from a repeated survey. Results The participants (mean age: 51.4 years; 53% women) were randomly assigned to cases (n = 3110) or controls (n = 3111). The data on primary outcomes were available for 1669 cases and 1655 controls. The rate of either applied or used rehabilitation services did not differ between the groups. Also, no differences were found in any of the secondary outcomes. Conclusions This randomized controlled study of 3,324 participants did not observe any additional value of web-based information guide to lower the threshold for applying for medical rehabilitation when comparing to a conventional printed information letter.
The course structure dilemma: Striving for Engineering students' motivation and deep learning in an ethics and history course

Citation for published version (APA): Bombaerts, G. J. T. , Doulougeri, K. I. , Spahn, A. , Nieveen, N. M. , & Pepin, B. E. U. (2018). The course structure dilemma: Striving for Engineering students' motivation and deep learning in an ethics and history course. In R. Clark, P. Munkebo Hussmann, H-M. Järvinen, M. Murphy, & M. Etchells Vigild (Eds.), Proceedings of the 46th SEFI Annual Conference 2018 : Creativity, Innovation and Entrepreneurship for Engineering Education Excellence (pp. 79-87). Brussels: Societe Europeenne pour la Formation des Ingenieurs (SEFI).
Rewarding the Factory Workers: How to Select the Right Measures for an Effective Pay-for-Performance System

Aims: A Performance related pay (PRP) plan rewards employees with a financial payment, either consolidated or non consolidated, following an assessment of their performance and, typically, the achievement of objectives. Many different types of PRP schemes have been developed over the years. Regardless of the scheme chosen, a particularly critical factor in the design of a performancerelated pay (PRP) plan concerns the choice of parameters or indicators on which variable pay should be determined. The research goal of this work is to develop an analytical model that can help companies to identify the optimal set of these parameters. Methodology: The model proposed in the paper has been developed through an empirical research methodology involving a large sample of companies. Data were collected by means of a questionnaire distributed to companies which have implementing for at least ten years a performance-related pay (PRP) scheme for shop-floor workers. Results: Descriptive and interpretative analysis of empirical results have identified a set of relationships between some company characteristics and the use of specific indicators for measuring the bonus to be given to the shop floor workers. The proposed model correlates three different typologies of companies (i.e. make to stock, make to order and engineering to order) with different types of indicators (i.e. profitability, productivity, efficiency and quality) which have to be Original Research Article Panizzolo et al.; AIR, 10(5): 1-19, 2017; Article no.AIR. 34518 2 used for bonus calculation. After having recognized to which category a firm belongs, it can easily identify the types of indicators to be used. Originality: The proposed model can actually help companies to identify the optimal set of parameters on which basing the PRP plan. A set of strong relationships have been recognized between some company characteristics and different types of indicators that should be employed for determining the variable bonus for shop-floor workers.
Lappeenranta-Lahti University of Technology LUT School of Business and Management Master’s Programme in International Marketing Management (MIMM)

Author Kimi Tiinus Title Congruence between a brand image and a film scene: The influence of product placement congruity in creation of consumer attitudes and emotional value Faculty School of Business and Management Master’s programme International Marketing Management (MIMM) Year 2019 Master’s thesis 69 pages, 20 figures, 3 tables, 1 appendix Examiners Professor Sanna-Katriina Asikainen & Associate Professor Anssi Tarkiainen
Proceedings of the 2nd International Workshop on Semantics for Biodiversity (S4BioDiv 2017)

Much of the work of creating open data repositories, and of enabling the sharing and discovery of their contents, is conducted by informatics specialists on behalf of the communities that they serve. Some, such as the genomics, remote sensing and medical communities, have a good record of participation in data sharing, custodianship, discovery and re-use, and are familiar with the procedures involved. Ecological scientists, especially those engaged in experimental and observational studies where the data are gathered personally, not through automatized means, are not so participative. Ecological scientists are, for a start, very possessive of their data; they are collected through their own blood, sweat, and tears. They know well the value of long-term observations and experiments in order to make scientific decisions about change (extinctions, rarity and so on), and are among the first to support their need, but they are reluctant to share their own data. In addition, the big questions that face ecological scientists demand that they work across disciplines as well as collaborate within their own community. The rates of data sharing and re-use by ecologists are among the lowest in the sciences, whereas data loss is comparatively high. Why? How can we improve this situation? I will discuss the particular challenges of dragging ecologists into the open data world. I will comment on the steps in the research data lifecycle where the requirements of participation are particularly distracting for ecologists. I will describe an initiative that has been developed to enable domain specialists to take control of their terminological understanding in a manner that facilitates the assembly of heterogeneous data sets, and at the same time prepares them for open delivery of their compiled data. I suggest that through this process, they will better understand the requirements for data sharing and custodianship, and will be more likely to participate in all facets of the open data world, improving the availability of long-term data sets!
Author ' s personal copy

Volcanism occurring away from ridges and subduction zones does not have an obvious plate tectonic explanation, but instead must arise from sub-lithospheric processes that generate upwelling flow and decompression melting. Several convective processes, such as mantle plumes, convective instability, edge-driven convection, and Richter rolls, produce upwelling via the action of gravity on density heterogeneities in the mantle. Here we investigate an alternative mechanism, the shear-driven upwelling (SDU), which instead generates upwelling solely through the action of asthenospheric shear flow on viscosity heterogeneity. Using a numerical flow model, we examine the effect of viscosity heterogeneity on viscous shear flow induced within an asthenospheric layer. We demonstrate that for certain geometries and viscosity ratios, circulatory flow develops within a “cavity” or “step” embedded into the lithospheric base, or within a low-viscosity “pocket” embedded within the asthenospheric layer. For asthenosphere shearing at 5 cm/yr, we estimate that SDU can produce upwelling rates of up to ∼0.2 cm/yr within a continental rift, ∼0.5 cm/yr along the vertical edge of a craton, or ∼1.0 cm/yr within a “pocket” of lowviscosity asthenosphere. In the last case, the pocket must feature an aspect ratio of more than 5, occupy ∼20–60% of the asthenosphere’s thickness, and be at least 100 times less viscous than the surrounding asthenosphere. Such viscosity heterogeneity may be associated with thermal, chemical, melting, volatile, or grain-size anomalies, and is consistent with tomographic constraints on asthenospheric variability. We estimate that SDU may generate up to 2.5 km/Myr of melt that is potentially eruptible as surface volcanism; this is faster than eruption rates observed at some locations of continental basaltic volcanism. We conclude that SDU could provide an explanation for intraplate volcanism occurring above rapidly shearing asthenosphere, for example in the Basin and Range region of North America. © 2009 Elsevier B.V. All rights reserved.
SHrimp : descriptive patterns in a tree

The appliance of the minimum description length (MDL) principle to the field of theory mining enables a precise description of main characteristics of a dataset in comparison to the numerous and hardly understandable output of the popular frequent pattern mining algorithms. The loss function that determines the quality of a pattern selection with respect to the MDL principle is however difficult to analyze and the selection is computed heuristically for all known algorithms. With SHrimp, the attempt to create a data structure that reflects the influences of the pattern selection to the database and that enables a faster computation of the quality of the selection is initiated.
Overview of Data and Eligibility for a Qualified Health Claim

This letter responds to the health claim petition submitted by the Global Organization for EPA and DHA Omega-3s (GOED or you) pursuant to sections 403(r)(4) and 403(r)(5)(D) of the Federal Food, Drug, and Cosmetic Act (the Act) (21 U.S.C. §§ 343(r)(4) and 343(r)(5)(D)). The Food and Drug Administration (FDA or the agency) received your petition on April 24, 2014.1 The petition requested that FDA authorize a health claim for the relationship between the consumption of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and reduction of blood pressure (BP). Based on discussions with you after we received the petition,2 we reviewed it as a petition for a qualified health claim in accordance with the July 10, 2003 Task Force Final Report on the Consumer Health Information for Better Nutrition Initiative.3
Improving Distributed Filesystem Performance by Combining Replica and Network Path Selection

Distributed filesystems are often the primary bandwidth consumers of large-scale datacenter networks. Unsurprisingly, the datacenter network is often the performance bottleneck for distributed filesystems. Yet even with this close relationship, current distributed filesystems and networks are designed independently and communicate over narrow interfaces that expose only their basic functionalities. Even network-aware distributed filesystems only make use of rudimentary network information, and are not reciprocally involved in making network decisions that affect filesystem performance. In this thesis, we introduce Mayflower, a new distributed filesystem co-designed with the control plane of its underlying datacenter network. This design approach enables Mayflower to combine both filesystem and network information to make replica selection and dynamic flow scheduling decisions. By having more information and controlling both the filesystem and the network, Mayflower can perform optimizations that are unavailable to conventional distributed filesystems and network control planes. Our evaluation results using a real implementation show that Mayflower reduces average read completion time by more than 60% compared to HDFS with ECMP.
Q-factor improvement of combline resonators

Abstract — In this paper, possibilities for increasing the quality factor of combline resonators are presented. Emphasis is placed on low fabrication costs. Circular and square shaped resonators are compared. The analysis is performed with a finite element simulator. To overcome numerical uncertainties of the Q-factor calculation, parametric sweeps and polynomial curve fitting are applied. As a result, the Q-factor can be increased by 5% by introduction of a base rounding.
Lessons from the trials ENGAGE AF : Effective anticoagulation with factor Xa in next generation treatment of atrial fibrillation

ENGAGE TRIAL The ENGAGE AF-TIMI 48 trial was a randomised, double-blind, double-dummy trial published in November 2013 in the New England Journal of Medicine. It compares two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high risk of stroke in AF. The study was conducted at 1393 centres across 46 countries and patients were enrolled between November 2008 and November 2010 with a median follow-up of 2.8 years. Patients were randomly allocated in a 1:1:1 ratio to receive either dose-adjusted warfarin or edoxaban at a high or low dose (60mg OD or 30mg OD). The dose of edoxaban was halved, either at randomisation or at any point throughout the study, if creatinine clearance was below 50ml/min, if body weight was 60 kg or less or if there was concomitant use of a potent P-glycoprotein inhibitor such as verapamil or quinidine. Each patient received a set of two drugs for the study, either warfarin plus placebo to match edoxaban, or edoxaban plus placebo to match warfarin. For patients in the edoxaban arm, blinding was maintained with sham INR values. Time in therapeutic range was calculated by means of linear interpolation, with INR values rounded to the nearest 0.1. The primary efficacy endpoint was defined as time to first adjudicated stroke (ischaemic or haemorrhagic) or systemic embolic event. The principal safety endpoint was adjudicated major bleeding during treatment, as defined by the International Society on Thrombosis and Haemostasis. An independent committee was allocated responsibility to adjudicate all deaths, cerebrovascular and systemic embolic events, myocardial infarctions and bleeding events. The baseline characteristics of the 3 study groups were well-balanced and complete information on the primary endpoint was attained for 99.5% of the total 56,346 patient-years of potential follow-up. The authors calculations estimated that the study had more than 87% power to reject the null hypothesis that edoxaban was inferior to warfarin.
Syddansk Universitet High-intensity interval , but not endurance training induces muscle fiber type-specific subsarcolemmal lipid droplet size reduction in type 2 diabetic patients

Citation for pulished version (APA): Koh, H-C. E. , Ørtenblad, N. , Winding, K. M. , Hellsten, Y. , Mortensen, S. P., & Nielsen, J. (2018). High-intensity interval, but not endurance training induces muscle fiber type-specific subsarcolemmal lipid droplet size reduction in type 2 diabetic patients. American Journal of Physiology: Endocrinology and Metabolism, 315(5), E872-E884. https://doi.org/10.1152/ajpendo.00161. 2018
High Technology Clusters , Flagship MNE Subsidiaries , and Mothership Ecosystems : Specialisation , Adaptation and Connectivity in Staving off Cluster Malaise

This paper links the literatures from international business and economic geography to explore how an industrial cluster extends its life-cycle and overcomes the vulnerabilities of technological specialization. The role of the MNE subsidiary and ancillary cluster members in this process is examined in a longitudinal study of the birth, growth and extended maturity of an Irish technological cluster. The case reveals the significance of interplays between the MNE subsidiary, the cluster that the subsidiary is a member of (the subsidiary? s ? host? cluster) and the parent company that is often itself part of a cluster (the parent? s ? home? cluster) in developing varied technological activity. Just as subsidiaries can ? tap into? the local cluster to source knowledge, local technological entrepreneurs can reverse the flow and access knowledge from the MNE parent? s home cluster.