Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification of Genes Induced during Apoptosis in T Lymphocytes

Recently, it has become clear that apoptosis, a form of programmed cell death, plays an active role in the maintenance of homeostasis of cells as well in the morphological sculpting of organisms during development (Ellis et al. 1991, White et al. 1994. Schwartz & Osborne 1993). Some of the best-characterized examples of apoptosis may be found in the immune system. For example. , apoptosis is the mechanism used during negative selection in the thymus to remove self-reactive T cells (Swat et al. 1991. Smith et al. 1989, Murphy et al. 1990). Tbymic T cells also are quite susceptible to induction of apoptosis by either glucocorticoids or ionizing radiation (Wyllie 1980, Selhns & Cohen 1987). Additionally, more recent data indicate that peripheral lymphocytes undergo apoptosis following a variety of different stimuli (Newell et al. 1990, Lenardo 1991, Russell et al. 1991, Razvi et al. 1993).
Review of Implicit Security Mechanisms for Cloud Computing

Cloud systems refer to the collection of interconnected servers that are provisioned dynamically on demand, for execution of applications, to the customer like electricity grid. Cloud computing has been drawing the interest from industry but there are still many issues that are in their primitive stage which are hampering the growth of cloud. One of these issues is security of data stored in the servers of datacenters of cloud service providers. Many schemes have been developed till date for ensuring security of data in distributed systems. In this paper implicit security using information dispersal and secret sharing algorithms have been reviewed which provides data security, reliability and availability of information.
Markov Models of Search State Patterns in a Hypertext Information Retrieval System

The objective of this research is to discover the search state patterns through which users retrieve information in hypertext systems. The Markov model is used to describe users' search behavior. As determined by the log-linear model test, the second-order Markov model is the best model. Search patterns of different user groups were studied by comparing the corresponding transition probability matrices. The comparisons were made based on the following factors: gender, search experience, search task, and the user's academic background. The statistical tests revealed that there were significant differences between all the groups being compared. © 1993 John Wiley & Sons, Inc.
How to profit from the balanced scorecard: An implementation roadmap

Purpose – The purpose of this paper is to identify a comprehensive set of potential determinants influencing the successful implementation of balanced scorecard (BSC). Design/methodology/approach – This research is an exploratory investigation into the BSC implementation based on a holistic view. This includes: a comprehensive scrutiny of the relevant literature; a comprehensive analysis of case studies of BSC implementations in organisations presented in the literature; and an exploratory global survey of 103 organisations in 25 countries that have already implemented or are in the process of implementing BSC.Findings – The roadmap presented in this paper has been taken from a model proposed in the study. The model contained 27 critical success factors which are expected to influence the BSC implementation. The model divides those factors into three levels, namely dominant, main, and supporting factors.Research limitations/implications – There is a need to empirically test and refine the proposed factors,.
Genetic pattern of prostate cancer progression

Genetic alterations in primary prostate cancer (CaP) have been extensively studied, yet little is known about the genetic mechanisms underlying progression of primary CaP to metastatic prostate cancer. As a result, it is not possible to distinguish clinically indolent localized disease from potentially life‐threatening tumors with high metastatic potential. To address this question, we collected tissue from 34 autopsy‐derived metastases, samples rarely analyzed in previous studies. These were compared to a separate set of 17 prostatectomy specimens containing 22 foci of CaP associated with 49 examples of high‐grade prostatic intraepithelial neoplasia (PIN), a histological precursor of CaP. We compared the loss of heterozygosity (LOH) profiles of high‐grade PIN, primary CaP and metastases by analyzing 33 microsatellite markers previously found to have high frequencies of LOH in primary CaP. These markers were on chromosomes 5q, 6q, 7q, 8p, 9p, 10q, 11p, 13q, 16q, 17, 18q and 21q. In addition, markers on chromosomes 4p, 11q, 14q and 20q with no reported LOH in primary CaP were analyzed to determine the frequency of background LOH. In PIN lesions, the rate of LOH was significant only at D5S806 (20%) and D16S422 (29%). In addition, different PIN lesions within the same prostate gland were genetically diverse, indicating divergent evolution of synchronous neoplastic precursor lesions. LOH frequency was progressively higher in primary CaP and metastatic lesions. In primary CaP, significant losses occurred at the 8p, 10q, 11p, 16q, 17p, 18q and 21q loci (range 17–43%). Distinct patterns of LOH frequencies were observed in primary CaP compared with metastases. Although some loci (D16S422, D17S960, D21S156) showed similar frequencies of LOH in primary CaP and metastatic CaP, most other loci showed up to 7‐fold metastasis‐related increases. The metastatic samples revealed previously unrecognized prostate cancer LOH at D5S806, D6S262, D9S157, D13S133 and D13S227. These significant stage‐specific differences in LOH frequency specify genetic loci that may play key roles in CaP progression and could represent clinically useful biomarkers for CaP aggressiveness. Int. J. Cancer 81:219–224, 1999. © 1999 Wiley‐Liss, Inc.
Bayesian Visual Tracking for Inspection of Undersea Power and Telecommunication Cables

The surveillance and inspection of underwater installations such as power and telecommunication cables are currently carried out by trained operators who, from the surface, guide a Remotely Operated Vehicle (ROV ) with cameras mounted over it. This manual visual control is, however, a very tedious job that tends to fail if the operator looses concentration. This paper describes a tracking system for underwater cables whose main objective is to allow an Autonomous Underwater Vehicle (AUV) to video-document the whole length of a cable. The approach is based on Particle Filters (PF) because of their natural ability to model multidimensional multi-modal probability density functions, what allows handling in a more appropriate way the ambiguities which naturally arise from undersea environments. Extensive experimental results over a test set of more than 10,000 off-line frames, for which a ground truth has been manually generated, have shown the usefulness of the solution proposed. All those images come from inspection runs captured by ROVs navigating over real power and telecommunication undersea cables. Besides, on-line results obtained from an unmanned vehicle guided by the cable tracker in a water tank are also available and are discussed in the paper.
Comparison of core needle biopsy and fine-needle aspiration of enlarged peripheral lymph nodes for antemortem diagnosis of enzootic bovine lymphosarcoma in cattle.

OBJECTIVE To determine whether antemortem core needle biopsy and fine-needle aspiration of enlarged peripheral lymph nodes could be used to distinguish between inflammation and lymphosarcoma in cattle. DESIGN Prospective study. ANIMALS 25 cattle with enlarged peripheral lymph nodes. PROCEDURES Antemortem biopsies of the selected lymph nodes were performed with an 18-gauge, 12-cm core needle biopsy instrument. Fine-needle aspirates were performed with a 20-gauge, 4-cm needle. Specimens were analyzed by pathologists who were unaware of clinical findings and final necropsy findings, and specimens were categorized as reactive, neoplastic, or nondiagnostic for comparison with necropsy results. RESULTS Sensitivity and specificity of core needle biopsy ranged from 38% to 67% and from 80% to 25%, respectively. Sensitivity of fine-needle aspiration ranged from 41% to 53%, and specificity was 100%. Predictive values for positive test results ranged from 77% to 89% for core needle biopsy and were 100% for fine-needle aspiration. Predictive values for negative test results were low for both core needle biopsy and fine-needle aspiration. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that core needle biopsy and fine-needle aspiration can aid in the antemortem diagnosis of bovine enzootic lymphosarcoma. Results of fine-needle aspiration of enlarged peripheral lymph nodes were more specific and more predictive for a positive test result than were results of core needle biopsy.
Intravitreal steroids versus observation for macular edema secondary to central retinal vein occlusion.

BACKGROUND Central retinal vein occlusion (CRVO) is a common retinal vascular abnormality associated with conditions such as hypertension, diabetes, glaucoma, and a wide variety of hematologic disorders. Macular edema (ME) represents an important vision-threatening complication of CRVO. There is no proven treatment; laser photocoagulation is not effective in treating cystoid macular edema secondary to CRVO. Intravitreal steroids, such as triamcinolone acetonide, have been utilized to treat macular edema stemming from a variety of etiologies and may represent a treatment option for CRVO-ME. OBJECTIVES The objective of this review was to explore the effectiveness and safety of intravitreal steroids in the treatment of CRVO-ME. SEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (The Cochrane Library Issue 4, 2008), MEDLINE (January 1950 to November 2008) and EMBASE (January 1980 to November 2008). There were no language or date restrictions in the search for trials. The electronic databases were last searched on 5 November 2008. For all included primary studies, we used The Science Citation Index and manually reviewed reference lists to identify other possible relevant trials. We contacted researchers in the field, currently working on a randomized controlled trial (RCT) on this topic (The Standard Care versus Corticosteroid for Retinal Vein Occlusion - SCORE study), for information on additional current, past, or unpublished trials. SELECTION CRITERIA We considered RCTs that compared intravitreal steroids of any dosage/duration to observation in the treatment of CRVO-ME for inclusion in this review. We focused on studies that included individuals of any age or gender with unilateral or bilateral disease, with a minimum of six months follow up. Secondarily we considered non-randomized studies with the same criteria for description of evidence, however we did not conduct a separate electronic search for finding all non-randomized studies. DATA COLLECTION AND ANALYSIS We found no RCTs that met the inclusion criteria after independent and duplicate review of the search results. MAIN RESULTS We found no relevant RCTs and therefore performed no meta-analysis. Evidence from non-randomized studies is reported in this review. AUTHORS' CONCLUSIONS There is inadequate evidence for the use of intravitreal steroids for CRVO-ME due to a paucity of RCTs and well-designed observational studies on the topic; therefore, it is still an experimental procedure.
Interleukin‐1β as a Mechanism for Stress‐Induced Startle Suppression in Females

Abstract: Startle measures were taken 2 h following a systemic injection of interleukin‐1β (IL‐1β) (3 μg/kg) to intact or ovariectomy (OVX) female rats. Changes in startle responsivity (reduced startle magnitude) were evident in intact IL‐1β‐treated rats, despite no significant effects on startle sensitivity (number of elicited startles). No significant changes in startle sensitivity or responsivity were evident in IL‐1β‐treated OVX rats. These results are discussed as a possible mechanism for stress‐induced suppression of startle responsivity seen in intact female rats.
Investigation of the Shielding Length on Yukawa System Crystallization in Mobile Sensor Network Applications

In modern information technology, mobile sensor networks (MSNs) play an important role in industrial or military applications, so sensor deployment is a key issue in MSN research. Based on wireless communication theory, hexagonal topology is known to provide the best field coverage, limited nodes, and minimal system cost. In the 2-D dusty plasma physical system, plasma particles are capable of forming a good hexagonal structure based on Yukawa system crystallization. Therefore, this strategy can be applied to node deployment algorithm in MSN applications. For this paper, we used a 2-D dusty plasma simulation in order to provide node deployment for a large sensor network, and, for better performance evaluations, adopted the Delaunay triangulation in order to determine adjacent particles of a given dust particle. Sensor deployment distributions and system performance were carefully examined by considering various values for the shielding length and the computation scale in simulations. Here, we discuss the influence of the shielding rule in Yukawa system crystallization on sensor deployment applications. Our results indicate that the algorithm leads to better field coverage with perfect hexagonal topology, good system uniformity, and lower energy consumption, and can be considered as an aid for fast deployment experiments when thousands of wireless sensors are required within a large-scale area.
Draft Genome Sequence of Paenibacillus sp. Strain DMB5, Acclimatized and Enriched for Catabolizing Anthropogenic Compounds

ABSTRACT Here, we present the draft genome sequence of Paenibacillus sp. strain DMB5, isolated from polluted sediments of the Kharicut Canal, Vatva, India, having a genome size of 7.5 Mbp and 7,077 coding sequences. The genome of this dye-degrading bacterium provides valuable information on the microbe-mediated biodegradation of anthropogenic compounds.
Regions of Mycoplasma pneumoniae cytadhesin P1 structural gene exist as multiple copies

The Mycoplasma pneumoniae cytadhesin P1 structural gene with flanking regions was labeled by nick translation and used as a probe to analyze gene copy number in M. pneumoniae. Multiple bands of genomic DNA were hybridized by the probe. To establish what part of the P1 gene existed as multiple copies, the P1 gene and regions adjacent to the 3' and 5' ends were divided with restriction enzymes into 14 segments ranging in size from 174 to 651 base pairs. These pieces were purified on agarose gels, subcloned into pUC19, purified, labeled by nick translation, and used to probe the entire M. pneumoniae genome. Several regions near the middle and carboxy end of the P1 structural gene hybridized to single copies. The remaining P1 subclones hybridized to multiple bands under stringent hybridization conditions, indicating extensive homology with other parts of the M. pneumoniae genome. The single- versus multiple-copy nature of P1 structural gene domains is discussed.
Kufor Rakeb Disease: Autosomal recessive, levodopa‐responsive parkinsonism with pyramidal degeneration, supranuclear gaze palsy, and dementia

Kufor Rakeb disease is an autosomal recessive disorder characterized by subacute, juvenile‐onset, levodopa‐responsive parkinsonism, pyramidal signs, dementia, and a supranuclear gaze palsy. It was originally described more than a decade ago, and linkage analysis identified a locus on chromosome 1p36 that was previously assigned PARK9. We have further characterized the clinical picture and specifically re‐assessed the response to levodopa in the original family, in the northern highlands of Jordan. In the 4 surviving patients, there has been a narrowing of the therapeutic window for levodopa with the emergence of peak‐dose dyskinesias with increased spasticity and cognitive decline. Several new features were identified, including facial‐faucial‐finger mini‐myoclonus, visual hallucinations, and oculogyric dystonic spasms. © 2005 Movement Disorder Society
MUC13 overexpression in renal cell carcinoma plays a central role in tumor progression and drug resistance

Metastatic renal cell carcinoma is a largely incurable disease, and existing treatments targeting angiogenesis and tyrosine kinase receptors are only partially effective. Here we reveal that MUC13, a cell surface mucin glycoprotein, is aberrantly expressed by most renal cell carcinomas, with increasing expression positively correlating with tumor grade. Importantly, we demonstrated that high MUC13 expression was a statistically significant independent predictor of poor survival in two independent cohorts, particularly in stage 1 cancers. In cultured renal cell carcinoma cells MUC13 promoted proliferation and induced the cell cycle regulator, cyclin D1, and inhibited apoptosis by inducing the anti‐apoptotic proteins, BCL‐xL and survivin. Silencing of MUC13 expression inhibited migration and invasion, and sensitized renal cancer cells to killing by the multi‐kinase inhibitors used clinically, sorafenib and sunitinib, and reversed acquired resistance to these drugs. Furthermore, we demonstrated that MUC13 promotion of renal cancer cell growth and survival is mediated by activation of nuclear factor κB, a transcription factor known to regulate the expression of genes that play key roles in the development and progression of cancer. These results show that MUC13 has potential as a prognostic marker for aggressive early stage renal cell cancer and is a plausible target to sensitize these tumors to therapy.
The Life Cycle of Clinical Decision Support(CDS): CDS Theory and Practice from Request to Maintenance

The promise of Clinical Decision Support (CDS) has always been to transform patient care and improve patient safety with delivery of timely and appropriate recommendations that are both patient-specific and more often than not appropriately actionable. However, the users of CDS, providers, are frequently bombarded with inappropriate and inapplicable CDS that is frequently neither informational, integrated into the workflow, patient-specific, and may present out of date and irrelevant recommendations. The life cycle of Clinical Decision Support begins with a request for CDS, continues with design and implementation, and concludes with ongoing knowledge maintenance. This State of the Practice will look at how using the best science and latest knowledge regarding CDS can create request and maintenance processes that work in the real world. Dr. David Bates will present the best science and knowledge behind CDS that works. Dr.’s Joseph Kannry and Thomas Yackel will present case studies of CDS requests and design processes that use this science to generate useful, useable, and timely patient-specific recommendations. Dr. Tonya Hongsermeier will present best practices in knowledge maintenance. Finally, Dr. Michael Krall will present a case study of knowledge maintenance from Kaiser Permanente that results in appropriate and up-to-date CDS.
Electrical addressing and temporal tweezing of localized pulses in passively mode-locked semiconductor lasers

This work presents an overview of a combined experimental and theoretical analysis on the manipulation of temporal localized structures (LSs) found in passively Vertical-Cavity Surface-Emitting Lasers coupled to resonant saturable absorber mirrors. We show that the pumping current is a convenient parameter for manipulating the temporal Localized Structures, also called localized pulses. While short electrical pulses can be used for writing and erasing individual LSs, we demonstrate that a current modulation introduces a temporally evolving parameter landscape allowing to control the position and the dynamics of LSs. We show that the localized pulses drifting speed in this landscape depends almost exclusively on the local parameter value instead of depending on the landscape gradient, as shown in quasi-instantaneous media. This experimental observation is theoretically explained by the causal response time of the semiconductor carriers that occurs on an finite timescale and breaks the parity invariance along the cavity, thus leading to a new paradigm for temporal tweezing of localized pulses. Different modulation waveforms are applied for describing exhaustively this paradigm. Starting from a generic model of passive mode-locking based upon delay differential equations, we deduce the effective equations of motion for these LSs in a time-dependent current landscape
Design of A Touch Sensor Based Single Finger Operated Wearable User-Interface Terminal

To reduce the constraints on user activities by user interface equipments, and to support wearable computing requirements, the current work reports the on-going development of a wearable multi-purpose input device. Touch of the fingertip over a ring like finger wearable device is sensed and the touch location and touch pressure information are interpreted to generate the intended command to the host system. Design requirements of single finger operated interface in the context of various applications are analyzed. The selected sensing approaches, sensor element placements and interpretation of user operations are explained. The features of the implemented prototypes are discussed
Trait Emotional Intelligence Related to Bullying in Elementary School Children and to Victimization in Boys

While Healthy People 2020 calls for a reduction of bullying among high school students as a public health priority, earlier intervention supported by Occupational Therapists may be warranted. The current study investigated the prevalence of bullying behaviors within an elementary school, compared the experiences of victims with those of perpetrators, and determined when and for whom Trait Emotional Intelligence is a predictor of bullying and victimization. Elementary school children (n = 235) in Grades 3 to 5 completed the Forms of Bullying Scale–Victim, the Forms of Bullying Scale–Perpetrator, and the Trait Emotional Intelligence Questionnaire–Child Short Form. The prevalence of bully-only perpetration was 3.0%, of victimization-only was 48.5%, and of bully-victimization was 10.4%. Trait Emotional Intelligence was negatively associated with bullying. Trait Emotional Intelligence was negatively associated with victimization in boys, but not girls. The findings are discussed within the need to provide instruction and services to students at an early age.
Software Engineering for the Internet of Things

No consolidated set of software engineering best practices for the Internet of Things (IoT) has yet emerged. Too often, the landscape resembles the Wild West, with unprepared programmers putting together IoT systems in ad hoc fashion and throwing them out into the market, often poorly tested. In addition, the academic sector is in danger of fragmenting into specialized, often unrelated research areas. This IEEE Software theme issue aims to help provide the basis for a set of best practices that will guide the industry through the challenges of software engineering for the IoT