Miracle-dz/UniFAR-FTUs huggingface dataset:
C-reactive protein +1059 GNC polymorphism in type 2 diabetes and coronary artery disease patients☆

Human C-reactive protein (CRP) is an acute phase reactant involved in chronic and acute inflammation. CRP is associated with metabolic syndrome, obesity, atherosclerosis, unstable angina, insulin resistance and diabetes. The present study evaluates the association of +1059 GNC silent polymorphism in exon 2 of CRP gene in 581 cases [CAD (206), T2D (266), T2D with CAD (109)] and 235 controls in the population of Punjab (North-West India). The frequency of +1059 G allele is highest in CAD (98.3%) followed by T2D (98.1%), T2D + CAD cases (97.7%) and controls (94.7%). G-allele is associated with increased risk of T2D [P = 0.003, OR = 2.93 (1.39–6.17)] and CAD [P = 0.004, OR = 3.25 (1.39–7.60)] in comparison to controls. Recessive model shows that GG genotype increases the risk of CAD by 4 fold (P = 0.003, OR = 4.19, 1.62–10.80), T2D by 3 fold (P = 0.008, OR = 3.23, 1.36–7.60) and T2D + CAD by 3.5 fold (P = 0.029, OR = 3.64, 1.14–11.66). Factor analyses show that BMI, WC, and WHR are core
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Natalizumab for the treatment of active Crohn’s disease: results of the ENCORE Trial Targan SR, Feagan BG, Fedorak RN, Lashner BA, Panaccione R, Present DH, Spehlmann ME, Rutgeerts PJ, Tulassay Z, Volfova M, Wolf DC, Hernandez C, Bornstein J, Sandborn WJ; International Efficacy of Natalizumab in Crohn’s Disease Response and Remission (ENCORE) Trial Group Background and aims: A randomized placebo-controlled trial evaluated the efficacy of natalizumab induction therapy in patients with Crohn’s disease.
Prevalence and correlates of HIV risk among adolescents and young adults reporting drug use: Data from an urban emergency department in the United States

ABSTRACT Adolescents and young adults who use substances are at particularly high risk for contracting human immunodeficiency virus (HIV). The emergency department (ED) is a critical location for HIV prevention for at-risk youth. To inform future interventions in the ED, this study identifies correlates of HIV risk behaviors among substance using youth seeking ED care. Among 600 youth aged 14 to 24 years with past 6-month drug use, bivariate correlates of HIV risk included older age, female gender, depressive symptoms, alcohol use, marijuana use, other drug use, and dating, peer, and community violence. Regression analyses indicated that older age, marijuana use, and dating violence were positively related to HIV risk. Results suggest HIV prevention efforts for youth in the urban ED should address marijuana use and dating violence as well as sexual risk behaviors.
Molecular Characteristics of Diffuse Large B-cell Lymphoma, Not Otherwise Specified

Abstract Diffuse large B-cell lymphoma (DLBCL) is a clinically and pathologically heterogeneous entity. Multiple molecular methods have been used to further understand and define this heterogeneity. Gene profiling has identified “cell-of-origin” molecular subtypes of DLBCL based on expression patterns similar to normal B-cells. These molecular subtypes are germinal center B-cell–like DLBCL and activated B-cell–like DLBCL and have been correlated with prognosis. These subtypes have also been associated with additional molecular alterations and preferential activation of specific oncogenic pathways. Other array-based molecular techniques such as microRNA, comparative genomic hybridization, and single nucleotide polymorphism arrays have also been applied to identify recurrent microRNA and gene copy number alterations. Most recently, next-generation whole-exome and whole-genome sequencing have provided further insight into the spectrum of genetic alterations in DLBCL. The biologic significance of these discoveries continues to be elucidated; however, emerging data are already informing treatment strategies that may target altered B-cell receptor signaling pathways and dysregulated epigenetic pathways. It will be important for pathologists to be familiar with the advances in our understanding of the molecular pathogenesis of DLBCL because they will certainly impact routine diagnosis, classification, and therapeutic decisions.
Examining School Building-Level Implementation of an MTSS Problem-Solving Team

The Multi-Tiered System of Support Problem-Solving Team (MTSS-PST) organizes the review of student learning data to identify problems, apply solutions, and evaluate progress towards grade level learning outcomes (Cook, Burns, Browning-Wright, & Gresham, 2010; Eagle et al., 2015; Gamm et al., 2012; Tilly, 2008). Outside of the MTSS framework, the PST is recognized as a best practice approach to identifying and implementing academic and social emotional interventions to improve learning outcomes (Algozzine et al., 2014; Burns & Symington, 2002; Doll et al., 2005; Shinn, 2005). Contemporary policy implementation research frames MTSS-PST as complex educational policy whose implementation is contingent upon, and situated by, interactions between the people implementing it, the policy itself, and the place where implementation occurs (Honig, 2006). There is little research, however, on MTSS-PST implementation. This study was designed to add to scholarly understanding of the MTSS-PST implementation process by examining how and why school building-level administrators were thinking about and planning for it. Analysis of the data revealed the following: (a) MTSS-PST implementation is understood by building-level administrators as an essential component in fulfilling the school district’s K-12 directive to reduce special education referrals with a Multi-Tiered System of Support framework; (b) Building-level administrative thinking and planning for MTSS-PST implementation is focused on reorganizing and improving how the school’s support team sorts students for support services; (c) Building administrator’s implementation decision-making is influenced by the simultaneous feeling of relief and burden brought on by the early success of implementation and the significant challenges it faces due to limited planning and resources. Analysis also showed that implementation is rooted in a transactional approach to change focused entirely on meeting districtwide objectives to increase the efficiency and efficacy of the school’s teaching and learning services with no reference to the transformative potential cited in the research literature. Lastly, analysis of the findings revealed that more than 70 different interactions that occurred between people, policy, and place shaped the MTSS-PST implementation process demonstrating that implementation of this policy is both situated and contextual.
EFFECT OF MITRAL REGURGITATION ON CHRONIC HEART FAILURE COURSE AND STRUCTURE-FUNCTIONAL HEART STATE

Aim. To evaluate chronic heart failure (CHF) course, functional and structural heart changes in patients with functional mitral regurgitation (MR) of various degrees. Material and methods. A total of 104 outpatients (60-85 y. o.) with CHF of functional class II-IV by NYHA and functional MR of I-II degrees and MR of III-IV degrees were included into the study groups. Results: Patients in both groups were comparable in sex, age, CHF duration, body mass index, systolic and diastolic blood pressure, clinical state by the clinical state scale, quality of life, anxious and depressive status. The majority of patients with MR III had significant left ventricle (LV) systolic dysfunction (p=0,029), severe CHF course (p=0,034), received furosemide (p=0.004) and digoxin (p=0,004). They had significant increase in end-diastolic dimension (p<0,001), end-systolic dimension (p<0,001), left atrium (p=0,004), end-diastolic vol￾ume (p<0,001), end-systolic volume (p<0,001), pulmonary artery pressure (p<0,001), decrease in LV relative wall thickness (p=0,021) and LV ejection fraction (p<0,001). Patients of this group were hospitalized because of CHF decompensation and ischemic heart disease exacerbation more often (p=0,045). Conclusion. MR can be considered as one of sensitive predictors of LV geometry and function alteration in CHF patients and play an important role in symptoms development.
Estimation of Provincial Tobacco Use in Thailand Using Multilevel Small Area Estimation from a National Probability Sample.

Monitoring tobacco use is one of the key tobacco control strategies proposed by World Health Organization to assess implementation of the Framework Convention on Tobacco Control. In Thailand, tobacco use surveillance is based on repeated nationally representative cross sectional surveys. While these surveys provide national estimates of tobacco use, they do not provide provincial level estimates because they were not designed with adequate provincial sample sizes. Provincial estimates of tobacco use are necessary for assessing local tobacco control policies. We used small area estimation (SAE) to estimate prevalence of current tobacco use in 76 provinces and Bangkok in Thailand with information from a national probability sample and census data. Multilevel logistic regression models with a provincial-level random effect were first estimated based on the Global Adult Tobacco Survey in Thailand and then applied to 2010 Thailand census data, i.e., aggregated number of people with demographic characteristics, to make predictions of current tobacco use for all target population groups in each province. The multilevel model provincial-level estimates were evaluated and validated by comparison to their direct survey estimates. Variation of prevalence of current tobacco use at the provincial level was large among province. The correlation between estimated prevalence using SAE and direct estimation was 0.966 and 0.919 for men and women respectively. In conclusion: Application of SAE to a Thailand nationally representative sample can be used for reliable estimation of prevalence of current tobacco use for all 76 provinces and Bangkok in Thailand.
Intraductal Tubular Carcinoma of the Pancreas: Differential Diagnosis and Distinction From Intraductal Tubular Adenoma

We describe a representative case of intraductal tubular carcinoma (ITC) of the pancreas, with particular emphasis on its differential diagnosis and morphologic features. Macroscopically, ITC shows nodular growth without mucus secretion and is confined within the main pancreatic duct. Histologically, ITC consists mainly of tubular glands in a back-to-back arrangement without evidence of multistep progression. The cuboidal cells are uniform. Pathologists face the challenge of distinguishing ITC from the intraductal tubular variant of acinar cell carcinoma, pancreatobiliary-type intraductal papillary mucinous carcinoma, and intraductal tubular adenoma (ITA). Histochemistry for mucins 1, 2, 5AC, and 6 and immunohistochemistry for trypsin can be helpful in distinguishing ITC from other intraductal neoplasms. The ITC in our case shows no K-ras exon 12 or 13 mutation, indicating that the lesion differs from ordinary intraductal papillary mucinous carcinoma. With a lining of columnar cells, the tubules of ITA resemble pyloric glands seen in the stomach. Together with the confirmed absence of mucin 5AC expression in our case, the present review indicates that ITC is not biologically associated with ITA, and ITA should be considered a phenotypic variant of intraductal papillary mucinous neoplasm.
Reducing Bias Through Gaming

How can games be used to reduce biases and biased behavior toward those people with special needs—if at all? In this paper I contextualize biases toward people with special needs, and also investigate possible intervention to encourage bias reduction. I also provide particular attention to educator biases around students with special needs, and how games may support interventions and professional development to reduce biases and biased behavior. Based on this, and the limited research on games, empathy, perspective-taking and bias reduction, I describe five possible strengths and four possible limitations of using games for these purposes.
Postpartum Headache as a Manifestation of Cerebral Tuberculoma

Tuberculosis continues to be an important public health problem in developing countries. The incidence of tuberculosis in pregnancy ranges between 1% and 2%, with only few case reports of cerebral tuberculoma during pregnancy. We present a case of a 28-yearold woman who presented with postpartum headache as a manifestation of cerebral tuberculoma and discuss the importance of clinical findings.
Clinical Practice Guideline Summary: Bell's Palsy

Reginald Baugh, MD; Gregory Basura, MD, PhD; Lisa Ishii, MD, MHS; Seth R. Schwartz, MD, MPH; Caitlin Murray Drumheller; Rebecca Burkholder, JD; Nathan A. Deckard, MD; Cindy Dawson, MSN, RN, CORLN; Colin Driscoll, MD; M. Boyd Gillespie, MD, MSc; Richard K. Gurgel, MD; John Halperin, MD, FAAN; Ayesha N. Khalid, MD; Kaparaboyna Ashok Kumar, MD, FRCS, FAAFP; Alan Micco, MD; Debra Munsell, DHSc, PA-C, DFAAPA; Steven Rosenbaum, MD, FAAEM; William Vaughan
A follow up study of vasectomy cases.

This paper is a study taken at the Family Planning and Research Centre Bombay in order to determine: 1) sexual behavior after vasectomy 2) the emotional reaction and 3) the occurrence of physical complications after vasectomy. 168 cases operated on during the 4-year period 1964-1967 were selected for interview. 20.9% had some complications. Of these 9 cases reported pain 9 experienced swelling 4 felt uneasy and the remaining 13 had fever insomnia nervousness bodyache headache purulent discharge or bleeding from the wound. Regarding sexual desire a year after the operation 82% felt normal 11.4% felt an increase in sexual desire and 6.5% felt a decrease. 81.9% experienced no change in the sexual act. Of those who experienced change 20% felt more intensity 16.6% less intensity 13.4% reported early ejaculation 10% reported satisfaction and 40% reported varied feelings--less or more erection pain physical disturbance or a sense of relief. 68.9% experienced no change in coital frequency one year after the operation while 16.7% reported less frequency and 14.4% experienced more frequency. Other topics covered included 1) change in general health 2) change in sexual behavior noticed by wife 3) previous use of contraceptives 4) period of use of contraceptives 5) vasectomy recommended to others 6) number of children after which vasectomy recommended 7) change in temperament and many more. Included in the report is the questionnaire sent to the vasectomy cases.
Kettlebell Safety: A Periodized Program Using the Clean and Jerk and the Snatch

ABSTRACT THE KETTLEBELL (KB) IS A WIDELY USED TOOL THAT IS OFTEN RECOMMENDED FOR THE IMPROVEMENT OF MUSCULAR STRENGTH, POWER, AND ENDURANCE. ALTHOUGH A FEW STUDIES SEEM TO SUPPORT THE USE OF KBS TO ACHIEVE THESE TRAINING GOALS, THE RESEARCH RESULTS ARE MIXED. GIVEN THE POPULARITY OF THE KB AS A TRAINING TOOL, IT IS IMPERATIVE THAT STRENGTH AND CONDITIONING COACHES AND OTHER FITNESS PROFESSIONALS INSIST ON HIGH-QUALITY EDUCATION/CERTIFICATION AND SAFE AND EFFECTIVE COACHING TO SAFEGUARD THE HEALTH AND SAFETY OF THEIR ATHLETES, CLIENTS, AND PATIENTS WHEN USING KBS. THE FOLLOWING ARTICLE OFFERS SAFETY CONSIDERATIONS AND A PERIODIZED KB PROGRAM. FOR A VIDEO ABSTRACT OF THIS ARTICLE, SEE VIDEO, SUPPLEMENTAL DIGITAL CONTENT 1, HTTP://LINKS.LWW. COM/SCJ/A131.
The design, use and effectiveness of different forms of content in e-learning tutorials

ion, interpretation and the integration of old with new. Schemata construction also underpins advice from Knowles (1973) in his discussion of Andragogy4 that, when teaching adults, new information should be explicitly linked to existing knowledge whenever possible. Similarly, Rowntree (1990), describing the tutorial-in-print prevalent in the early days of the Open University, suggests: "Explain the subject matter in such a way that learners can relate it to what they know already" (p82). Further support comes from other related principles such as Subsumption Theory (Ausube1, 1963) and Elaboration Theory (Reigeluth, 1979), both of which are discussed further in Chapter 3. The route to long term memory and schemata construction is VIa working memory (Figure 2.1), the limited capacity of which cited for many years as 7 ± 2 items (Miller, 1956) restricts our information processing capability. More recently, Cowan (2001) suggests a lower capacity of 4 ± 1 items and Sweller (2005) that working memory " . can probably process in the sense of combine, contrast or manipUlate no more than about 2-4 elements" (p22). Such limitations are not thought to apply to familiar information that is already organised into schemata (van Merrienboer & Ayres, 2005) but they do apply to the novel, unorganised infonnation that can often feature in the learning process. Sensory Inputs (Sight, Sound, Touch, Smell and Taste) Sensory Memory + Unattended information is lost ~
Effect of the Angiotensin-Converting–Enzyme Inhibitor Benazepril on the Progression of Chronic Renal Insufficiency

Background Drugs that inhibit angiotensin-converting enzyme slow the progression of renal insufficiency in patients with diabetic nephropathy. Whether these drugs have a similar action in patients with other renal diseases is not known. We conducted a study to determine the effect of the angiotensin-converting–enzyme inhibitor benazepril on the progression of renal insufficiency in patients with various underlying renal diseases. Methods In a three-year trial involving 583 patients with renal insufficiency caused by various disorders, 300 patients received benazepril and 283 received placebo. The underlying diseases included glomerulopathies (in 192 patients), interstitial nephritis (in 105), nephrosclerosis (in 97), polycystic kidney disease (in 64), diabetic nephropathy (in 21), and miscellaneous or unknown disorders (in 104). The severity of renal insufficiency was classified according to the base-line creatinine clearance: 227 patients had mild insufficiency (creatinine clearance, 46 to 60 ml per minu.
HQ-Learning

HQ-learning is a hierarchical extension of Q(λ)-learning designed to solve certain types of partially observable Markov decision problems (POMDPs). HQ automatically decomposes POMDPs into sequences of simpler subtasks that can be solved by memoryless policies learnable by reactive subagents. HQ can solve partially observable mazes with more states than those used in most previous POMDP work.
A comparison of single- and multi-band attention models by use of short duration noise pulses

Two experiments were conducted to compare the single and multi-band models of selective attention. Previous work cited in the literature had shown conflicting results both confirming and discrediting the models. Some of the data may be accounted for by assuming a change in the subject's (S's) response criterion. Therefore, the present study examined the concepts of time-sharing and Theory of Signal Detectability (TSD) in relation to auditory selective attention.
Development of an anthropomorphic arm for manipulation

Nowadays, service robots are used for private or research usage, like in space programs to explore planets, or in an University project. This dissertation is mainly focused on the development of an anthropomorphic arm and its assemble on the platform CAMBADA@Home to participate and achieve better results in the RoboCup competition. In this dissertation it will be explained how the robotic arm for CAMBADA@Home was developed. This will include the motors used, BLDC motor and Dynamixel servo motors, as well as the construction of a model of the arm with the use of a CAD software, which involves the use of the motors designed and the creation of some parts to connect them, as well as the assembly of the physical model. Afterwards the hardware and software control were developed. It was also used a simulator in order to safely test the model. Then a few test were run which consisted on the use of no load an with a load of 263 grams. Additional test were run to verify if the planning sequence matched the physical trajectory. key words: ROS, anthropomorphic arm, BLDC motor, Dynamixel servo motor, GAZEBO, MoveIt!
FRI0213 Anti-TNF therapy in refractory uveitis of behcet’s syndrome. A multicenter study of 63 patients

Objectives To assess the efficacy of Infliximab (IFX) and adalimumab (ADA) in refractory uveitis of Behçet’s syndrome. Methods Study of 63 patients followed in the Uveitis Clinic of 24 hospitals. All of them were refractory to conventional therapy with systemic steroids and ≥1 immunosuppressive drug. Efficacy was evaluated according to SUN criteria, and macular thickness by optical coherence tomography (OCT). Outcomes and comparisons were made at week 1, week 2, month 1, month 6 and at 1 and 2 years. Statistical analyses were performed using the STATISTICA (Statsoft). Results were expressed: mean±1SD (normally distributed variables) or median [25th-75th interquartile range-IQR] (not normally). Continuous variables were compared with the Wilcoxon test. Results We studied 63 patients/110 affected eyes (36M, 27W), mean age 38.9±9.0 years. Prior to anti-TNF, patients had received ivMprednisolone (n=20), cyclosporine (CyA) (n=53), methotrexate (MTX) (n=31) and azathioprine (AZA) (n=30). IFX was the anti-TNF more commonly used (64%). The remaining patients (36%) were treated with ADA. 14 patients (22%) required switching (12 from IFX→ADA; 2 ADA→IFX). Dosage: IFX 5 mg/kg/iv every 4-8 weeks or ADA 40 mgsc/2weeks. The median[IQR] follow-up from the onset of anti-TNF was 36 [20-60] months. Significant improvement of Visual acuity (VA), Tyndall and vitritis was observed soon (week 1). At 2 years,VA improved from 0.5±0.3 at basal to 0.7±0.3 (p<0.001), Tyndall from a median of 1.07 [0-2] to 0.09 [0-0] (p<0.001) and vitritis, from 1.0 [0-2] to 0.0 [0-0], respectively. Initially,17 patients (24 eyes) had cystoid macular edema (CME). Following anti-TNF OCT decreased from 320.2±120.9 to 260.4±42.8 at 2 years (p<0.001). The most serious side effect was a miliary tuberculosis in 1 patient at month 1 after the onset of IFX. Basal (N) 1 week 1 month 6 months 1 year 2 year patients/eyes (% inactive eyes) (% inactive eyes) (% inactive eyes) (% inactive eyes) (% inactive eyes) Tyndall 42/68 28% 97% 80% 88% 93% Vitritis 53/85 33% 55% 75% 84% 90% Choroiditis 10/18 39% 45% 100% 100% 100% Retinal vasculitis 55/85 25% 59% 90% 97% 95% CME (>300μm) 17/24 13% 13% 63% 63% 79% *Inactive if: anterior inflammation Tyndall = 0, vitritis = 0, choroiditis, retinitis/retinal vasculitis: no activity and CME if OCT <250. Conclusions Monoclonal anti-TNF therapy is effective and relatively safe in uveitis of Behcet’s syndrome refractory to conventional therapy. Disclosure of Interest None Declared