Miracle-dz/UniFAR-FTUs huggingface dataset:
2. The Beauty of Complex Designs

The increasing use of omics data in epidemiology enables many novel study designs, but also introduces challenges for data analysis. We describe the possibilities for systems epidemiological designs in the Norwegian Women and Cancer (NOWAC) study and show how the complexity of NOWAC enables many beautiful new study designs. We discuss the challenges of implementing designs and analyzing data. Finally, we propose a systems architecture for swift design and exploration of epidemiological studies. epidemiological analysis, and exploration of hypotheses. We present a high-level, conceptual architecture for this missing system.
Effects of a surface circulator on temperature, dissolved oxygen, water velocity, and photosynthetic yield in Falling Creek Reservoir

Cyanobacteria are a naturally occurring component of reservoir aquatic ecosystems. Given that some species possess the ability to control their depth within the water column, they have a competitive advantage over other species of photosynthetic organisms. This leads to the potential for cyanobacteria blooms, and because of taste and odor problems, as well as possible toxin production associated with certain species of cyanobacteria, these organisms can cause major problems in drinking water production. The Western Virginia Water Authority installed a solar-powered circulator in Falling Creek Reservoir, located in Bedford County, Virginia, in an attempt to limit the growth of these organisms through limiting light exposure by circulating them deeper within the reservoir. Experiments were performed during the summer of 2008 to quantify the effect of the circulator on the reservoir. Temperature, dissolved oxygen, water velocity, and photosynthetic yield were monitored before and during operation of the unit. The overall effect of the mixer was limited to the first 10 m immediately adjacent to the unit during the afternoon. The effect was stronger during the morning when the difference in density between the intake water and the surface of the reservoir was smaller, allowing the water to travel up to 80 m away from the unit. Although the circulator was only intended to mix and possibly deepen the epilimnion, the entire reservoir became mixed about two weeks after the circulator was put into operation. The reservoir is quite shallow, leading to a weak stratification that is easily disrupted by the operation of the circulator.
Almost Inner Derivations of Some Nilpotent Leibniz Algebras

We investigate almost inner derivations of some finite-dimensional nilpotent Leibniz algebras. We show the existence of almost inner derivations of Leibniz filiform non-Lie algebras differing from inner derivations, we also show that the almost inner derivations of some filiform Leibniz algebras containing filiform Lie algebras do not coincide with inner derivations
Respiratory equations – behind the numbers

South Afr J Anaesth Analg 2020; 26(6)Supplement http://www.sajaa. co.za Southern African Journal of Anaesthesia and Analgesia. 2020;26(6 Suppl 3):S90-93 https://doi.org/10.36303/SAJAA.2020. 26.6. S3.2546 Open Access article distributed under the terms of the Creative Commons License [CC BY-NC 3.0] http://creativecommons.org/licenses/by-nc/3.0 South Afr J Anaesth Analg ISSN 2220-1181 EISSN 2220-1173 © 2020 The Author(s)
Supporting Learning through Learning Management Systems in an ODL Environment amid Covid-19: Technology Accessibility and Student Success

Although prior research looked into the effects of LMSs upon student success, little is known on the effects of LMSs on student success, particularly during the current Covid-19 pandemic. Informed by technology acceptance model (TAM), this study explores the linkage between the geographic setting and the accessibility of NTs, and examines effects of LMSs upon student academic success in ODL in the context of Covid-19. The purpose of this chapter is to indicate how teaching and learning pedagogies is impacted by the novel coronavirus within the global open and distance learning education system and to suggest possible mechanisms to support students through learning management systems in order to reduce student attritions and to accelerate student success rate. I used a mixed-methods methodological lens, blending the self-administered questionnaires for 177 students with unstructured in-depth interviews with 2 regional directors, and 4 learning and facilitation managers during data collection. I analysed data descriptively and thematically, unveiling, from all cohorts of participants that the greater proportion of students are from remote rural areas with a considerable limited access to technologies, which ultimately adversely influences upon their usage and academic achievements. However, its continued use was valued salient with a potential to improve students’ academic performance and success. I conclude that inaccessibility to new technologies for teaching and learning has a bearing on students’ success. I propose that ODL institutions should support students by increasing accessibility of technologies through the provision of gadgets and data as well as establishing learning support centres and encourage students to use them in learning.
Chinese text classification method using FastText and term frequency-inverse document frequency optimization

With the development of information technology, obtaining information quickly and accurately has become an indispensable part of people’s lives. Text classification can filter and organize massive text data to find valuable information, and its practical application is of great significance. This paper proposes Chinese text classification method using FastText and term frequency-inverse document frequency optimization(I-FastText). This method introduces term frequency-inverse document frequency(TF-IDF) optimization into the input layer of FastText model, removes words with high frequency and low discrimination ability, and achieves high-quality word vectors to train the text classification model. The experimental results on the THUCNews dataset shown that the Chinese text classification accuracy of I-FastText is significantly better than TF-IDF and FastText methods.
Review—Where Is Dielectrophoresis (DEP) Going?

A guide is offered to new researchers (and their supervisors) of the most promising topics to explore in market-driven or curiosity-driven dielectrophoresis (DEP) research. Based on an analysis of publications since 2000, contributions from electronic engineers and materials scientists are likely to be maintained, with increasing emphasis on the development of DEP-based protocols for chemical and biochemical analyses that involve nanoparticles. Two modes of DEP are likely to dominate, namely metal-electrode based (eDEP) and insulator-based (iDEP). Where high values of the electric ﬁeld and its gradient are required, such as the spatial manipulation of nanoparticles (e.g., exosomes, proteins, viruses, carbon-nanotubes), eDEP would in many cases be the preferred choice. This would also be the case for the selective isolation of biological cells; the development of cell-based drug discovery protocols; electronic sensors and the assembly of nanoparticles (e.g., carbon nanotubes). Applications of iDEP would be particularly suited for the separation or detection of bioparticles such as DNA, RNA, proteins or bacteria, where manipulation selectivity is based on differences in surface charge. Hot topics include the development of dynamic patterning of bioparticles using photoconductive electrodes, and the genome-wide mapping between genotype and DEP phenotype of cells. ©
Crucial Role of the YAP/TEAD Axis in Osteosarcoma Tumor Growth: Effects of YAP Inhibitors Verteporfin and CA3 on Tumor Growth in vivo

BackgroundOsteosarcoma is the first primary bone tumor in children and adolescents. Despite progress in the understanding of the biology of these tumors, survival rates have progressed very little in recent decades. In this context, although some studies suggested that disruption of the Hippo signaling pathway is associated with osteosarcoma progression, the molecular mechanisms by which YAP regulates primary tumor growth is not fully clarified. In addition, the validation of YAP as a therapeutic target through the use of inhibitors in a preclinical model must be demonstrated.MethodsThe identification of a YAP signature was carried out by RNAseq analysis from a cohort of patients. Survival rates were assessed by Kaplan-Meier assays. The role of TEAD in the control of osteosarcoma cell proliferation by YAP has been realized by various molecular and cellular biology approaches (RNAseq, PLA, immunoprecipitation, promoter/specific gene, proliferation, cell cycle assays) using overexpression of mutated forms of YAP able or unable to interact with TEAD. The role of TEAD in YAP regulation of primary tumor growth, and the effects of YAP inhibitors in vivo were realized using an orthotopic model of osteosarcoma. ResultsRNA-seq analysis and Kaplan-Meier assays identified a YAP signature in osteosarcoma patients and a correlation with patients outcome. Molecular and cellular analysis using overexpression of mutated forms of YAP able or unable to interact with TEAD, indicate that TEAD is crucial for YAP-driven cell proliferation and in vivo tumor growth. In addition, in vivo experiments show that two YAP/TEAD inhibitors, verteporfin and CA3, reduce primary tumor growth. In this context, in vitro experiments demonstrate that these inhibitors decrease YAP expression, YAP/TEAD transcriptional activity and cell viability mainly by their ability to induce cell apoptosis.ConclusionWe thus demonstrate that the YAP/TEAD signaling axis is a central actor in mediating primary tumor growth of osteosarcoma, and that the use of YAP inhibitors may be a promising therapeutic strategy against osteosarcoma tumor growth.
Various classifications for architectural form finding process

In the age of digital revolution, architects have to keep pace with latest advances in technology and computing, which in turn affected architectural design and fabrication. In architectural form finding process, some schools of thought encourage personal inspiration, intuition of the architect and his sense of beauty, while others depend on specific design approaches based on rules and fulfillment of design requirements in generating architectural form. This paper presents a review on various form finding philosophies that have been existed in architectural design over the past century till now. In addition, a taxonomy for digitally generated forms is presented herein into two categories. Through investigating these different approaches of form finding process, some of them focus only on the qualitative and aesthetic aspects of the architectural form and didn’t take into consider building performances such as functional, environmental, structural or acoustic, while others focus on the performative aspects. Moreover, dealing with the current complex geometries and advanced technologies made it important to depend on an Integrated design: a Generative performative design Approach that achieves balance and takes into consider both aesthetic aspects as well as the performative considerations of the building such as functional, environmental, structural or economic, in order to find the optimal solution at early stages of the form finding process.
A Distilled BERT with Hidden State and Soft Label Learning for Sentiment Classification

BERT is a pre-trained language model. Although the model is proven to be highly performant in a variety of natural language understanding tasks, its large size makes it hard to implement in practical situation where computing resource is limited. In order to improve the model efficiency of BERT for sentiment analysis task, we propose a novel distilled version of BERT. It distills knowledge from the full-size BERT model, which serves as the teacher model. The distilled model efficiently learns the last hidden state and soft label of the teacher model, which are different from previous models. We use distillation learning objective that is able to effectively transfer knowledge from the original big model to the compact model. Our model reduces BERT model size by ∼40%, but retains ∼98.2% of performance in sentiment classification task. Our model achieves promising results in SST-2 sentiment analysis, and outperforms previous distilled model.
Sensorimotor and Body Perception Assessments of Chronic Nonspecific Low Back Pain: A Case-Control Study

Background: Low back pain is one of the most common musculoskeletal disorders. It leads to major costs in health care systems and causes significant personal and social burdens. Current research focuses on the processes of the central nervous system such as cortical changes in pain perception to discover new and more efficient ways to treat chronic low back pain (CLBP). Several clinical tests have been suggested that might correlate with altered cortical representation. These include back-photo assessment (BPA), movement control tests (MCI) and two-point discrimination thresholds (TPD). Objective: The aim of this study was to determine whether BPA, MCI and TPD tests can discriminate between CLBP patients with altered body perception and healthy controls.Design: A case-control study matched by gender and age.Methods: Using MCI, BPA and TPD tests on the lower back, thirty patients with CLBP and thirty healthy controls were investigated at one point in time. Participants were also required to complete three questionnaires: the ‘Fear Avoidance Belief Questionnaire’, the ‘Hospital Anxiety and Depression Scale’ and the ‘Fremantle Back Awareness Questionnaire’. Correlations among the main covariates and odds ratios for group differences were calculated.Results: The MCI showed a statistically significant odds ratio for the presence of CLBP of 0.65 (p< 0.05), whereas TPD and BPA did not determine differences between the groups.Conclusion: The movement control test was found to be the only suitable test to discriminate CLBP patients from healthy controls.Trial registration: The study was approved by the Swiss Ethical Commission Northwest and Central Switzerland (EKNZ) and registered at 21.8. 2015, reference number 2015-243.
Cross-domain effect of pitch processing in lexical and melodic contexts reflected by non-musicians: An MEG study

The pitch processing of language and music is generally considered engaging overlapped neural correlates. Previous studies on musicians showed that the ability of pitch processing in music could be transferred to language. It is known that music training can facilitate neural processing of speech, however, the underlying neural mechanisms of pitch processing of language and music are not fully understood, especially in non-musicians. Using magnetoencephalography, we presented a pitch anomaly paradigm which consists of language/music phrases ending in either congruous or incongruous tones/pitches to non-musicians. We found the distinctive brain activity patterns in two groups with high and low musical pitch perceptual abilities. The brain-behavior results showed a positive correlation between the performance of musical pitch tasks and the activation of the left frontotemporal cortical regions elicited by lexical tones. Our results suggested that the cross-domain effect of language and music could be generalized to people without formal music training.
Introduction to Innovative Capabilities and the Globalization of Chinese Firms

How do Chinese companies learn to innovate and compete on global markets? This book explores how Chinese firms are developing capabilities for innovation and globalization, in relation to their economic environment. Firms studied here are active in a variety of different industries, ranging from pharmaceuticals and artificial intelligence to transportation, telecommunication, and mechanical manufacturing. Taken together, the chapters in this book provide a conceptualization of one restricted part of the vast transformation ongoing in China. This book does not aim to cover all types of Chinese firms, nor all the transformations ongoing within China per se. Instead, our focus is upon the three intertwined processes involving innovation, technological capabilities, and globalization. Western countries have long taken the lead in developing knowledge and transforming it into business and social innovation, but in recent decades the Chinese economy has been rapidly advancing. Chinese firms are developing innovative capabilities and engaging in globalization, which affects not only China but also the world. Hence, this book only focuses upon a selected few Chinese firms and industries which already have shown to be – or are actively striving to become – world-leading in their technologies and markets. We are interested in why and how they use and develop advanced technology as well as how they can obtain economic returns on the market, often global markets. More generally, we have chosen to study firms and industries which are attempting to move the basis of their competitiveness from imitation to innovation; from being a player on a home market to a global market; and from being a follower to being an innovative leader. Our analysis places these firms in relation to the
Putrescine-functionalized carbon quantum dot nanoparticles (Put-CQD) effectively prime grape (Vitis vinifera cv. Sultana) against salt stress

BackgroundSalinity is an important global problem with destructive impacts on plants leading to different biochemical and metabolic changes in plants through induced oxidative stress that disturbs metabolism, growth, performance and productivity of plants. Given that putrescine (Put) and carbon quantum dots (CQDs), individually, have promising effects on different plants processes, the idea of their combination in a nano-structure “Put-CQD” caused to its synthesizing for doubled positive effects. The current study aimed to investigate the application of newly-synthesized nanoparticles (NPs) consisting of CQDs and Put on grapevine (Vitis vinifera cv. Sultana) under salinity stress conditions. For this purpose, Put, CQDs and Put-CQD NPs at 5 and 10 mg L-1 concentrations were applied as chemical priming agents on ‘Sultana’ grapes 48 h prior salinity imposition (0 and 100 mM NaCl). ResultsSalinity significantly decreased (P≤0.05) morphological parameters, photosynthesis pigments, chlorophyll fluorescence parameters and membrane stability index. In addition, salinity enhanced MDA, H2O2, proline and antioxidant enzymes activity. The results revealed that Put-CQD NPs, particularly at 10 mg L-1 concentration, alleviated the destructive impacts of salinity stress by improving leaf fresh and dry weights, K+ content, photosynthetic pigments, chlorophyll fluorescence and SPAD parameters, free proline content, total phenolics and antioxidant enzymatic activities (CAT, APX, GP and SOD), while decreasing Na+ content, EL, MDA and H2O2 levels. ConclusionTo conclude, Put-CQD NPs represent an innovative priming treatment that could be effectively applied on grapevine to improve plant performance under salinity stress conditions.
Lift The Flap Storybook to Grow and Raise Awarness about Sugar Intake in Early Chilhood and Their Parents

This research entitled Lift The Flap Storybook to Grow and Raise Awarness about Sugar Intake in Early Chilhood and Their Parents. The purpose of this research is to develop a media to grow and raise understanding of the balanced proportion of sugar intake in early chilhood and their parents. The expected benefit from this research is to provide educational media that is easy to use and understand, and does not harm children, besides that it can instill awareness of healthy living from an early age and an understanding of the importance of balanced food intake by parents for family members. This research is a development research (R & D) using a qualitative approach as a data collection and analysis process. The subject of this research involved 20 parents who have early childhood as participants/media users and also three experts in the field of early childhood education, graphic design, and language as validators. The results of this research showed that: a) of the 20 participants who were involved in the study, 9 families had a pattern of excess sugar consumption, b) the results of media feasibility validation by experts show that the content, design and language in the media are in the good and very good categories, c) the results of trials related to the effectiveness of the use of media by users (parents and children) show that there is an increase in awareness as indicated by changes in sugar consumption patterns in children and parents (families) which initially tend to be more balanced. Keywords : Lift The Flap Storybook, Sugar Intake Awareness, Earlychilhood and Parents.
Real-Time Sign Language Learning System

Learning sign language can be fun and easy when a suitable learning method is used. Different people would have different interest level in learning sign language, and this also can be affected by their communication skills. With the traditional teaching method, there would be a lot of constraints that could stop the learner from learning effectively. This work proposes a learning platform to address these concerns and facilitating sign language learners in gaining the required knowledge. The developed web application includes online learning materials such as videos, and incorporates interactive elements such as a practice session to increase the efficiency of the learning process. The findings indicate that the Sign Language Learning System could be effective for those who are interested in learning sign language.
Development of an Expedient Process for the Multi-Kilogram Synthesis of Chk1 Inhibitor GDC-0425

A process leading to the multikilogram GMP synthesis of Chk1 inhibitor GDC-0425 (1) was developed. Highlights of the synthesis include protection of the pyrrole ring of a 1,7-diazacarbazole as propyl ethyl ether, an efficient Pd catalyzed cyanation of an aryl chloride, aryl ether formation by SNAr fluoride displacement, and development of a controlled crystallization providing the API with the required polymorphic form. The process delivered high-quality GDC-0425 with low levels of impurities and residual metals in five steps and 31% overall yield.
Avaliação

O presente artigo resulta de um estudo teórico sobre a avaliação. Partiu de pesquisadores que constituem leitura clássica sobre a temática e produções recentes que apresentam uma visão crítica sobre o ato de avaliar. Propôs-se compreender o significado da avaliação com aporte na Teoria Histórico-Cultural que tem no Materialismo Histórico-Dialético os fundamentos para compreender a constituição da psique humana. Constatou-se que o significado da avaliação é proveniente dos processos de trabalho - atividade que marca o desenvolvimento humano. A avaliação educacional é condizente com os fins estabelecidos para a educação e a concepção de avaliação é definidora dos procedimentos avaliativos.