Miracle-dz/UniFAR-FTUs huggingface dataset:
Developing “MinDag” – an app to capture symptom variation and illness mechanisms in bipolar disorder

Introduction The illness course of bipolar disorder (BD) is highly heterogeneous with substantial variation between individuals with the same BD subtype and within individuals over time. This heterogeneity is not well-delineated and hampers the development of more targeted treatment. Furthermore, although lifestyle-related behaviors are believed to play a role in the illness course, such mechanisms are poorly understood. To address some of these knowledge gaps, we aimed to develop an app for collection of multi-dimensional longitudinal data on BD-relevant symptoms and lifestyle-related behaviors. Methods An app named MinDag was developed at the Norwegian Center for Mental Disorders Research in Oslo, Norway. The app was designed to tap into selected areas: mood, sleep, functioning/activities (social, occupational, physical exercise, leisure), substance use, emotional reactivity, and psychotic experiences. Ethical, security and usability issues were highly prioritized throughout the development and for the final app solution. We conducted beta- and pilot testing to eliminate technical problems and enhance usability and acceptability. Results The final version of MinDag comprises six modules; three which are presented for the user once daily (the Sleep module in the morning and the Mood and Functoning/Activities modules in the evening) and three which are presented once weekly (Substance Use, Emotional Reactivity, and Psychotic Experiences modules). In general, MinDag was well received in both in the beta-testing and the pilot study, and the participants provided valuable feedback that was taken into account in the final development. MinDag is now in use as part of the research protocol at the NORMENT center and in a specialized treatment unit for BD at Oslo University Hospital in Norway. Discussion We believe that MinDag will generate unique longitudinal data well suited for capturing the heterogeneity of BD and clarifying important unresolved issues such as how life-style related behavior may influence BD symptoms. Also, the experiences and knowledge derived from the development of MinDag may contribute to improving the security, acceptability, and benefit of digital tools in mental health.
CRISPR/Cas9 suppression of OsAT10, a rice BAHD acyltransferase, reduces p-coumaric acid incorporation into arabinoxylan without increasing saccharification

Ester-linked hydroxycinnamic acids ferulic acid (FA) and para-coumaric acid (p-CA) play important roles in crosslinking within cell wall arabinoxylans (AX) and between AX and lignin in grass cell walls. The addition of hydroxycinnamates to AX, is mediated by the Mitchell clade of BAHD acyl-coenzyme A-utilizing transferases. Overexpression of OsAT10 (a Mitchell clade BAHD acyl transferase) in rice, has previously been shown to increase p-CA content in AX in leaves and stems, leading to increased cell wall digestibility, potentially associated with a concomitant decrease in FA content. To investigate the physiological role of OsAT10 we established CRISPR/Cas9 rice knock-out mutants devoid of OsAT10. Our analysis of hydroxycinnamic acid content in wild type plants revealed that AX associated p-CA is found almost exclusively in rice husks, with very little found in other tissues. Mutant plants were essentially devoid of ester-linked p-CA associated with AX, indicating that OsAT10 represents the major enzyme responsible for the addition of p-CA to arabinoxylan in rice plants. We found no change in the digestibility of rice husk lacking AX-associated p-CA, suggesting that the changes in digestibility seen in OsAT10 overexpressing plants were solely due to compensatory decreases in AX-associated FA.
Identification of Anti-HIV Biomarkers of Helichrysum Species by NMR-Based Metabolomic Analysis

Several species of the Helichrysum genus have been used ethnobotanically to treat conditions that we today know have been caused by viral infections. Since HIV is a modern disease with no ethnobotanical history, we commenced with a study on the anti-HIV activity of several Helichrysum species. Drug discovery of small molecules from natural resources that is based on the integration of chemical and biological activity by means of metabolomical analyses, enables faster and a more cost-effective path to identify active compounds without the need for a long process of bioassay-guided fractionation. This study used metabolomics to identify anti-HIV compounds as biomarkers from 57 Helichrysum species in a combined study of the chemical and biological data of two previous studies. In the OPLS-DA and hierarchical cluster analyses, anti-HIV activity data was included as a secondary observation, which assisted in the correlation of the phytochemical composition and biological activity of the samples. Clear grouping revealed similarity in chemical composition and bioactivity of the samples. Based on the biological activity of polar extracts, there was a distinct phytochemical difference between active and non-active groups of extracts. This NMR-based metabolomic investigation showed that the chlorogenic acids, compounds with cinnamoyl functional groups, and quinic acid were the most prominent compounds in the Helichrysum species with anti-HIV activity. This study further revealed that the chlorogenic acid type compounds and quinic acid are biomarkers for anti-HIV activity.
Top Management Commitment as an Important Factor in the Success of Enterprise Resource Planning (ERP) System in State Owned Companies

This research is expected to find out whether top management commitment has an influence on the success of Enterprise Resource Planning (ERP) system and what the impact is on the quality of resulted accounting information. This research is hoped to become an evident that the research model presented may become a solution in solving problems and give benefits in developing knowledge related to the success of ERP system which affects to the resulted accounting information quality. Methodology used in the research was explanatory research, to get basic answers on causes and effects by analyzing the causes of a problem. Data collection was done by handing out questionnaires to state owned companies in Indonesia, and the data were analysed with SEM PLS. Results show that top management commitment has an influence on the ERP system and also gives impact to the resulted output that was making accounting information reliable.
Effects of International Institutional Factors on Earnings Quality of Banks

We examine the relation between legal, extra-legal and political institutional factors and earnings quality of banks across countries. We predict that earnings quality is higher in countries with legal, extra-legal and political systems that reduce the consumption of private control benefits by insiders and afford outside investors greater protection. Using a sample of banks from 29 countries over the period from 1993 to 2006, we find all five measures of earnings quality studied are higher in countries with stronger legal, extra-legal and political institutional structures. Our findings highlight the implications of institutional environments for financial reporting quality and are relevant to bank regulators who are considering additional regulations on bank financial reporting. JEL classification: G34; G38; M41
The role of foot posture and motion on external knee adduction moment : implications for the effectiveness of lateral wedge insoles

The knee joint is the most common joint affected by osteoarthritis (OA). The medial compartment of the knee is more commonly afflicted with OA than the lateral compartment. Lateral wedge insoles (LWI), a common treatment approach for the conservative management of medial compartment knee OA, have previously been considered effective in reducing external knee adduction moment (EKAM). LWI aim to shift a proportion of knee load from the medial compartment to the lateral compartment of the knee joint, providing some symptomatic relief. Foot posture may influence the efficacy of LWI in reducing the EKAM due to its effect on the dynamic function and mechanical alignment of the lower limbs. This thesis investigated the role of foot posture on the magnitude of EKAM and impact on the effectiveness of LWI for the treatment of medial compartment knee OA. Firstly, a repeatability trial was conducted to ensure investigator competency, and reliability of the methods and outcome measures utilised. Secondly, a trial using healthy subjects assessed rearfoot posture using the Foot Posture Index (FPI) to determine if a relationship existed between static foot posture and biomechanical rearfoot motion and their effects on EKAM when wearing LWI, to determine whether clinical foot parameters have a role in the magnitude of EKAM. The role of foot posture in response to LWI, the effects of foot posture on the efficacy of LWI, and effects and impact on EKAM in patients with medial compartment knee OA were assessed. No relationship was identified between clinical static foot posture, biomechanical rearfoot motion, and EKAM. However, a relationship existed between rearfoot motion and EKAM. Rearfoot range of motion can therefore predict the response to LWI. The thesis then examined research questions in regards to the collection of rearfoot motion using different methods (a heel cup cluster and a heel pin cluster) demonstrating that heel pin cluster marker sets are an acceptable method of determining rearfoot motion in barefoot and shod walking. Due to changes in walking speed with lateral wedge insoles the role of increased walking speed on the magnitude of EKAM when wearing LWI was assessed. Increasing walking speed with LWI reduced biomechanical response. The thesis has demonstrated a further understanding of foot posture and ankle motion in healthy subjects and in individuals with medial compartment knee OA. Further clinical studies investigating the role of rearfoot motion and biomechanical response to lateral wedge insoles are indicated.
Single-Handed Gesture UAV Control for First Responders - A Usability and Performance User Study

Unmanned aerial vehicles (UAVs) have increased in popularity in recent years and are now involved in many activities, professional and otherwise. First responders, those teams and individuals who are the ﬁrst to respond in crisis situations, have been using UAVs to assist them in locating victims and identifying hazards without endangering human personnel needlessly. However, professional UAV controllers tend to be heavy and cumbersome, requiring both hands to operate. First responders, on the other hand, often need to carry other important equipment and need to keep their hands free during a mission. This work considers enabling ﬁrst responders to control UAVs
Addiction and Rational Choice: Evidence from an Eye Tracking Experiment with Cigarette Packages

We asked 97 current cigarette smokers to make 12 binary choices between experimental packages with varying warnings and background colors. Each participant had to decide which of the two packages contained cigarettes less risky for his health. Confronted with repugnant, threatening images, these smokers nonetheless made choices that were context independent, adhered to transitivity, and consistent with an additive utility model. Eye tracking measurements confirmed that the choices of 65 percent of participants were further compatible with a noise-reducing lexicographic utility model. This subset of participants smoked significantly more cigarettes per day. Our findings support a model in which addiction permits the smoker to suppress aversive stimuli and negative emotions that would otherwise interfere with short-term rational decision making.
Individual behavioral responses of an intermediate host to a manipulative 1 acanthocephalan parasite and effects of intra-specific parasitic competition 2

Individual behavioral responses of an intermediate host to a manipulative 1 acanthocephalan parasite and effects of intra-specific parasitic competition 2 3 4 5 6 Timo Thünken, Simon Vitt, Sebastian A. Baldauf, Tina Jung, Joachim G. Frommen 7 1 Institute for Evolutionary Biology and Ecology, University of Bonn, An der Immenburg 1, 8 53121 Bonn, Germany 9 2 Institute of Ecology and Evolution, Department of Behavioural Ecology, University of Bern, 10 Wohlenstrasse 50a, 3032 Hinterkappelen, Switzerland 11 12 Corresponding author: phone: +49 228 735114, e-mail: tthuenken@evolution.uni-bonn.de 13 Evolutionary Ecology Research — Volume 19 (2018)
Talent attraction in Swedish Gaming Industry. An exploratory study.

Researchers and practitioners have both acknowledged the importance of attracting the right employees. The study aims to explore and analyze how Swedish gaming start-ups attract talent. The authors investigated eight gaming companies based in Sweden, conducting semi-structured interviews with founding team or management team that were responsible for talent attraction in their respective companies. Study draws on theory of employer brand and examines how game development start-ups overcome their challenges in employee attraction context. Results of the research show that most gaming companies offer variety of employment benefits described in employment brand theory, but for them to have a competitive advantage, they should incorporate innovative new ideas in talent attraction. We propose an ‘employer innovation matrix model’ that can be a strategic talent attraction planning tool for companies.
Modulation by Cytokines Interaction: Lymphocytes via Fas/Fas Ligand Crosstalk Between Keratinocytes and T

Apoptosis mediated by Fas/FasL interaction plays an important role during many inﬂammatory skin disorders. To estimate whether the expression of FasL, the ligand for Fas, might be regulated by cytokines we stimulated primary human keratinocytes with several pro- and anti-inﬂammatory cytokines. Keratinocytes cultured to subconﬂuence expressed FasL constitutively. Cells stimulated with the proinﬂammatory cytokines IL-1 b , TNF- a , IFN- g , and IL-15, respectively, increased signiﬁcantly their intracellular as well as cell surface-bound FasL expression in a time- and dose-dependent manner. This cytokine-induced FasL expression was dependent on new protein synthesis. Despite enhanced expression of cell surface-bound FasL, no release of soluble FasL was measured in the cell supernatants determined by ELISA. Stimulation of the cells with IL-6, IL-10, IL-12, TGF- b 1, and GM-CSF did not modulate the constitutive FasL expression, but IFN- g -mediated FasL up-regulation was signiﬁcantly diminished by IL-10 and TGF- b 1, respectively. Up-regulation of FasL on IFN- g -stimulated keratinocytes led to increased apoptosis within monolayers cultured for 48 h. Moreover, coculture experiments performed with Fas 1 Jurkat T cells revealed that enhanced FasL expression on IFN- g -stimulated keratinocytes induced apoptosis in cocultured T cells, demonstrating that up-regulated FasL was functionally active. In summary, our data suggest the important regulatory role of cytokine-controlled Fas/FasL interaction in the cross-talk between keratinocytes and skin-inﬁltrating T cells for maintenance of homeostasis in inﬂammatory skin processes. The Journal of Immunology, 1999, 162: 7140–7147.
Random Matrix Approach t o Quant urn Adiabatic Evolution Algorithms

We analyze the power of quantum adiabatic evolution algorithms (Q-QA) for solving random "-hard optimization problems within a theoretical framework based on the random matrix theory (R\IT). We present two types of the driven RMT models. In the f h t model. the driving Hamiltonian is represented by Brownian motion in the matrix space. We use the Brownian motion mode! to obtain a description of multiple avoided crossing phenomena. We show that the failure mechanism of the QAA is due to the interaction of the ground state with the "cloud formed by all the excited states, confirming that in the driven RMT models. the Landau-Zener mechanism of dissipation is not important. n e show that the QilEA has a finite probability of success in a certain range of parameters. implying the polynomial complexity of the algorithm. The second model corresponds to the standard QAhA with the problem Hamiltonian taken from the Gaussian Unitary RMT ensemble (GUE). We show that the level dynamics in this model can be mapped onto the dynamics in the Brownian mc-tion model. However, the driven RXT model always leads to the exponential complexity of the algorithm due to the presence of the long-range intertemporal correlations of the eigenvalues. Our results indicate that the weakness of effective transitions is the leading effect that can make the Markovian type QAEA successful.
Survey of Different Partition Clustering Algorithms and their Comparative Studies

: Clustering is one of the most important research areas in the field of data mining. Clustering means creating groups of objects based on their features in such a way that the objects belonging to the same groups are similar and those belonging in different groups are dissimilar. Clustering is an unsupervised learning technique. Data clustering is the subject of active research in several fields such as statistics, pattern recognition and machine learning. From a practical perspective clustering plays an outstanding role in data mining applications in many domains. The main advantage of clustering is that interesting patterns and structures can be found directly from very large data sets with little or none of the background knowledge. Data mining adds to clustering the complications of very large datasets with very many attributes of different types. This imposes unique computational requirements on relevant clustering algorithms. A variety of algorithms have recently emerged that meet these requirements and were successfully applied to real-life data mining problems. They are subject of this survey. Also, this survey explores the behavior of some of the partition based clustering algorithms.
An AFLP-based genetic linkage map for the butterfly Bicyclus anynana , covering all 28 chromosomes 1

The butterfly Bicyclus anynana is emerging as a model organism in the field of evo-devo, life history evolution and ageing. However, there are limitations to the detail in which these traits can be unraveled without basic knowledge about genome architecture. A genetic linkage map allows separate components of traits to be identified and linked to distinct chromosomal regions and to study their effect in more detail in a context of functionality and interaction. Therefore, a linkage map was constructed for B. ananynana to serve as a resource to facilitate future investigations. Linkage mapping had to take account of absence of crossing-over in female Lepidoptera, and of our use of a full-sib crossing design. We developed a new method to determine and exclude the non-recombinant uninformative female inherited component in offspring. The linkage map was constructed using a novel approach that uses exclusively JOINMAP-software for Lepidoptera linkage mapping. This approach simplifies the mapping procedure, avoids over-estimation of mapping distance and increases the reliability of relative marker positions. A total of 347 AFLP markers, 9 microsatellites and one single-copy nuclear gene covered all 28 chromosomes, with a mapping distance of 1354 cM. Conserved synteny of Tpi on the Z-chromosome in Lepidoptera was confirmed for B. anynana . The results are discussed in relation to other mapping studies in Lepidoptera. This study contributes to the knowledge of chromosome structure and evolution of an intensively studied organism. On a broader scale it provides an insight in Lepidoptera sex chromosome evolution and it proposes a simpler and more reliable method of linkage mapping than used for Lepidoptera to date.
in Fly, and

splicing orders for hundreds or thousands of genes in four organisms. I found 29 humans contain more number of not in-order spliced transcripts. intron order in each The method requires sequencing reads from ribo-minus depleted short-read mate-pair sequencing or ribo-minus depleted long-read sequencing. A simulation study showed that the method developed here can accurately calculate intron splicing orders. While using published long-read sequencing and short-read sequencing datasets, I calculated intron splicing orders for hundreds or thousands of genes in S. pombe , fruit fly, Arabidopsis thaliana , and humans. The results suggest that although splicing is a co- process, the splicing order varies from gene to gene. I found more not in-order spliced transcripts than S. pombe thaliana . In addition, I confirmed that the first tend slower
Immunotherapy in Mice Memory B Cell Depletion during CD20 Serological Memory Despite Mature and Maintenance of Long-Lived Plasma Cells and

CD20 mAb-mediated B cell depletion is an effective treatment for B cell malignancies and some autoimmune diseases. However, the full effects of B cell depletion on natural, primary, and secondary Ab responses and the maintenance of Ag-speciﬁc serum Ig levels are largely unknown. The relationship between memory B cells, long-lived plasma cells, and long-lived humoral immunity also remains controversial. To address the roles of B cell subsets in the longevity of humoral responses, mature B cells were depleted in mice using CD20 mAb. Peritoneal B cell depletion reduced natural and Ag-induced IgM responses. Otherwise, CD20 (cid:1) B cell depletion prevented humoral immune responses and class switching and depleted existing and adoptively transferred B cell memory. Nonetheless, B cell depletion did not affect serum Ig levels, Ag-speciﬁc Ab titers, or bone marrow Ab-secreting plasma cell numbers. Coblockade of LFA-1 and VLA-4 adhesion molecules temporarily depleted long-lived plasma cells from the bone marrow. CD20 (cid:1) B cell depletion plus LFA-1/VLA-4 mAb treatment signiﬁcantly prolonged Ag-speciﬁc plasma cell depletion from the bone marrow, with a signiﬁcant decrease in Ag-speciﬁc serum IgG. Collectively, these results support previous claims that bone marrow plasma cells are intrinsically long-lived. Furthermore, these studies now demonstrate that mature and memory B cells are not required for maintaining bone marrow plasma cell numbers, but are required for repopulation of plasma cell-deﬁcient bone marrow. Thereby, depleting mature and memory B cells does not have a dramatic negative effect on preexisting Ab levels. The Journal of Immunology, 2008, 180: 361–371. B1,
Compositional Advantage and Strategy

In this paper, I first critique the composition-based view of Yadong Luo and John Child for understanding how resource-poor firms survive and thrive. To remedy the deficiencies in their perspective, I then propose a dynamic theory of compositional advantage and strategy. Here, the compositional advantage is redefined as the attractiveness of the composition of the producer’s offering in terms of scope and perceived value/price ratio. I identify five ways or basic compositional strategies to improve the value/price ratio. A firm may have an overall compositional strategy that is composed of some or all of the five basic compositional strategies. I argue there are three indispensable key success factors for a composition-based competition, i.e., aspiration (ambition-position asymmetry), attitude (being ALERT), and action (turning asymmetry into advantage). I also discuss the particular relevance of the present theory to understanding Chinese firms. I conclude with managerial implications and suggestions for future research.