Miracle-dz/UniFAR-FTUs huggingface dataset:
Targeted degradation of BRD 9 reverses oncogenic gene 1 expression in synovial sarcoma 2 3

9 Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston Children’s 10 Hospital and Harvard Medical School, Boston, MA 02115, USA. 11 Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02215, 12 USA. 13 Department of Cancer Biology, Abramson Family Cancer Research Institute, 14 Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, 15 USA. 16 School of Biomolecular and Biomedical Science and Conway Institute, University 17 College Dublin, Belfield, Dublin 4, Ireland. 18 Department of Molecular Biology, Faculty of Science, Radboud Institute for 19 Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, The Netherlands 20 Department of Molecular Biology, Faculty of Science, Radboud Institute for 21 Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, Nijmegen, 22 The Netherlands 23 Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215. 24 Division of Translational Oncology, National Center for Tumor Diseases (NCT) 25 Heidelberg and German Cancer Research Center (DKFZ), 69120, Heidelberg, 26 Germany. 27 8 German Cancer Consortium (DKTK), 69120, Heidelberg, Germany. 28 9 Section for Personalized Oncology, Heidelberg University Hospital, 69120, 29 Heidelberg, Germany. 30 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. 31 Smurfit Institute of Genetics, Trinity College Dublin, Ireland. 32 † Present address: Novartis Institutes for BioMedical Research, Cambridge, MA 33 02139, USA. 34
Title Sustainable Development in an Aging Economy

In this paper, we analyze the effects of population aging on economic growth and the environment in a two-period overlapping generations model of growth, aging, and the environment. We show that aging may be beneficial to economic growth and the environment under perfect annuitisation, while possibly harmful under imperfect annuitisation. We also discuss the implications of our results for environmental policy in an aging economy. JEL Classification: J10, J14, O10, D62, D90.
Title Archaeal β diversity patterns under the seafloor alonggeochemical gradients

Recently, deep drilling into the seafloor has revealed that there are vast sedimentary ecosystems of diverse microorganisms, particularly archaea, in subsurface areas. We investigated the β diversity patterns of archaeal communities in sediment layers under the seafloor and their determinants. This study was accomplished by analyzing large environmental samples of 16S ribosomal RNA gene sequences and various geochemical data collected from a sediment core of 365.3 m, obtained by drilling into the seafloor off the east coast of the Shimokita Peninsula. To extract the maximum amount of information from these environmental samples, we first developed a method for measuring β diversity using sequence data by applying probability theory on a set of strings developed by two of the authors in a previous publication. We introduced an index of β diversity between sequence populations from which the sequence data were sampled. We then constructed an estimator of the β diversity index based on the sequence data and demonstrated that it converges to the β diversity index between sequence populations with probability of 1 as the number of sampled sequences increases. Next, we applied this new method to quantify β diversities between archaeal sequence populations under the seafloor and constructed a quantitative model of the estimated β diversity patterns. Nearly 90% of the variation in the archaeal β diversity was explained by a model that included as variables the differences in the abundances of chlorine, iodine, and carbon between the sediment layers.
A general framework for animal density estimation from acoustic detections across a fixed microphone array

Acoustic monitoring can be an efficient, cheap, non‐invasive alternative to physical trapping of individuals. Spatially explicit capture–recapture (SECR) methods have been proposed to estimate calling animal abundance and density from data collected by a fixed array of microphones. However, these methods make some assumptions that are unlikely to hold in many situations, and the consequences of violating these are yet to be investigated. We generalize existing acoustic SECR methodology, enabling these methods to be used in a much wider variety of situations. We incorporate time‐of‐arrival (TOA) data collected by the microphone array, increasing the precision of calling animal density estimates. We use our method to estimate calling male density of the Cape Peninsula Moss Frog Arthroleptella lightfooti. Our method gives rise to an estimator of calling animal density that has negligible bias, and 95% confidence intervals with appropriate coverage. We show that using TOA information can substantially improve estimate precision. Our analysis of the A. lightfooti data provides the first statistically rigorous estimate of calling male density for an anuran population using a microphone array. This method fills a methodological gap in the monitoring of frog populations and is applicable to acoustic monitoring of other species that call or vocalize.
A large, long-lived structure near the trojan L5 point in the post common-envelope binary SDSS J1021+1744

SDSS J1021+1744 is a detached, eclipsing white dwarf/M dwarf binary discovered in the Sloan Digital Sky Survey (SDSS). Outside the primary eclipse, the light curves of such systems are usually smooth and characterized by low-level variations caused by tidal distortion and heating of the M star component. Early data on SDSS J1021+1744 obtained in 2012 June were unusual in showing a dip in flux of uncertain origin shortly after the white dwarf's eclipse. Here we present high-time resolution, multiwavelength observations of 35 more eclipses over 1.3 yr, showing that the dip has a lifetime extending over many orbits. Moreover the ‘dip’ is in fact a series of dips that vary in depth, number and position, although they are always placed in the phase interval 1.06–1.26 after the white dwarf's eclipse, near the L5 point in this system. Since SDSS J1021+1744 is a detached binary, it follows that the dips are caused by the transit of the white dwarf by material around the Lagrangian L5 point. A possible interpretation is that they are the signatures of prominences, a phenomenon already known from H α observations of rapidly rotating single stars as well as binaries. What makes SDSS J1021+1744 peculiar is that the material is dense enough to block continuum light. The dips appear to have finally faded out around 2015 May after the first detection by Parsons et al. in 2012, suggesting a lifetime of years.
Educational Climate In Elective Adult Education: Shared Decision Making and Communication Patterns

Educational climate represents the social and contextual qualities of an organization as perceived by the participants. The theoretical construct of educational climate encompasses a range of variables which have been categorized as ecology, milieu, social system, and culture (Tigiuri, 1968). These categories are similar to the elements of the andragogical process described by Knowles (1984). In this research, the theoretical climate category of social system emerged as influential in an ethnographic study of an elective university program. Findings revealed that shared decision making and communication patterns were instrumental in the quality of the adult learning experience.
Cash Flow and Discount Rate news estimation: Which method to choose?

This paper documents that the VAR method for estimating the Discount Rate and Cash Flow News components of stock returns at the firm level produces results that are highly sensitive to research design choices. To alleviate these concerns, an alternative method of the news estimation is proposed. This method is based on Campbell and Shiller's (1988) return decomposition, but directly computes the Cash Flow News as the sum of the revisions in analysts' forecasts without relying on the VAR system as a modeling mechanism for market expectations (RAF method). Moreover, this method does not require estimation of the implied cost of capital as proposed by Chen and Zhao (2010). Empirical results provide evidence that the RAF method outperforms both VAR and Chen and Zhao's (2010) methods. Monte-Carlo simulations suggest that the RAF method more accurately captures Cash Flow and Discount Rate news.
OCCUPATIONAL SAFETY AND HEALTH REGULATION

An employer will invest in safety and health precautions until the cost is more than the expense of paying higher wages, workers’ compensation, and other accident and illness costs. Employees receive additional protection because governments have chosen to augment these financial incentives with regulation. Studies indicate that all three approaches cause employers to invest in health and safety precautions, but the extent to which injuries and illnesses are reduced is difficult to verify and may be limited in numerous work situations. The literature has identified potential reforms, but the viability of key reforms is uncertain. Thus, labor markets, compensation and regulation are highly imperfect alternatives concerning the reduction of occupational accidents and illnesses. As a result, continued reliance on all three approaches is indicated.
Which first-year students are making most learning gains in STEM subjects?

ABSTRACT With the introduction of the Teaching Excellence Framework a lot of attention is focussed on measuring learning gains. A vast body of research has found that individual student characteristics influence academic progression over time. This case-study aims to explore how advanced statistical techniques in combination with Big Data can be used to provide potentially new insights into how students are progressing over time, and in particular how students’ socio-demographics (i.e. gender, ethnicity, Social Economic Status, prior educational qualifications) influence students’ learning trajectories. Longitudinal academic performance data were sampled from 4222 first-year STEM students across nine modules and analysed using multi-level growth-curve modelling. There were significant differences between white and non-White students, and students with different prior educational qualifications. However, student-level characteristics accounted only for a small portion of variance. The majority of variance was explained by module-level characteristics and assessment level characteristics.
Laboratory biogas production from kitchen wastes and applying an adaptive neuro fuzzy inference system as a prediction model.

Biogas, a clean and renewable energy could be very well substitute for conventional sources of energy. In this study kitchen wastes potential for biogas production was investigated. Batch digestion experiments were accomplished in the laboratory using 1L capacity bottle reactors at ambient temperature, and the effect of some parameters such as solid waste concentration and sheep manure percentage on the gas production efficiency was investigated. Also an adaptive nero-fuzzy interference system (ANFIS) was proposed as a prediction model to predict biogas production through kitchen wastes digester. The selected experimental data were trained by a hybrid learning algorithm. The algorithm combines the forward pass and the backward pass. The developed model was validated and statistically analyzed using scatter diagram through actual and predicted data. The ANFIS predicted data demonstrated reasonable agreement with actual data.
PUBLIC KEY FULLY HOMOMORPHIC ENCRYPTION

The meaning of cloud computing is the Information Technology (IT) model for computing, which is consist of all the IT components (software, hardware, services and, networking ) that are needed to enable delivery and development of cloud services through the private network or the internet. In the cloud computing the client put his data on the cloud, and any computations on his stored data will be implemented in the cloud. Intentionally the cloud service provider can access, change or even delete the stored data of the client. To produce the effective services, some of the cloud service providers share the information with third parties. The third party can access to the client private data and modifies on this data to make it beneficial to him. Moreover, providers, untrusted servers, and cloud operators can keep identifying elements of users long after users end the relationship with the services. For these reasons, the security has become the most important thing in cloud computing. The mechanism that protects the privacy of sensitive information is called the encryption. To protect the data that it’s stored on the cloud we must use an encryption system that can perform computations on the encrypted data. The scheme that allows to executing several computations on the encrypted message without decrypting this message is called homomorphic encryption. This paper provides encryption scheme (PKFHE) that can applied it on a cloud computing . The proposed scheme is based on Euler’s theorem, which proved both addition and multiplication operations at the same time on ciphertext without decryption. we compute the time complexity of the encryption and decryption function for the Elgamal, RSA cryptosystems and our proposed PKFHE scheme which, the order of encryption function of all the schemes is O ((log (n))3) and the order of decryption function of Elgamal, RSA cryptosystems is O (log (n)3), while the order of decryption function of PKFHE scheme is O (log (n)2) that mean the proposed PKFHE scheme is faster in the time complexity. Also compared the execution time among the three schemes with five sizes of the messages and used five lengths of a secret key, where we concluded that the execution time of the proposed scheme was slower than the execution time of Elgamal, RSA cryptosystems except in the case of the key 128-bit which, the execution time of RSA was slower than the two others. Also we noticed that the length of the private key was effect on the execution time of the algorithms in which the execution time increased when the length of the private key was increase and finally the security of the schemes is analyzed. The proposed scheme showed a good security for the stored data on the cloud.
Average income , income inequality and

This paper analyses the relationship between a country’s income distribution and its exports’ unit values. Using bilateral export flows, we not only confirm the positive association between a country’s average income and its export unit values, but further identify a heterogeneous relationship with income inequality: we find a greater income spread to be associated with higher exports unit values in the case of poor countries only. These results are robust to the inclusion of controls for other determinants of export unit values, as well as to the use of alternative measures of income inequality and of the quality index. We finally show that this heterogeneous relationship between income inequality and export unit values along the average income dimension is consistent with models emphasizing the role of the composition of local demand in determining the comparative advantage of countries in terms of quality.
Revision : Correlating Revision Procedure and Error Detection

This article reports on an empirical study on translation revision. With the aim of investigating the possible link between revision procedure and quality, the research correlates an indicator of quality, error detection, with revision procedure. Error detection and revision procedure were studied drawing on a convergent parallel mixed-methods research design involving three different sources of data. Nine subjects performed a revision task and thus produced text data; their activities on the computer screen were captured and saved as video fi les; and retrospective interviews were conducted with the revisers upon completion of the task. Results show that the highest error detection scores were linked with a variety of revision procedures, but with one common denominator: the target text was consistently the point of departure. Revisers with high error detection scores thus engaged in various different revision procedures, but their focus of attention in the initial operations was the translation rather than the source text in all cases. Conversely, the revisers whose initial attention was directed towards the source text received the lowest error detection scores in the revision task.
ERK 1 / 2 phosphorylation is required for hepatic differentiation of human umbilical cord-derived mesenchymal stem cells 2

Mesenchymal stem cells (MSCs) have the capacity to restore liver function by differentiating into hepatocyte like cells. However, the underlying mechanisms are not well understood. Here, we have investigated the signals involved in the hepatic differentiation of human umbilical cord-derived mesenchymal stem cells (hUCMSCs) 3 . hUCMSCs were treated with mouse fetal liver-conditioned medium (FLCM) to induce hepatic differentiation. Flow cytometry, reverse transcription PCR 4 , real-time PCR, immunocytochemistry, and PCR array were used to detect the expression of MSCand hepotocyte-specific markers in FLCM-treated hUCMSCs. Urea production and cytochrome P450 3A4 (CYP3A4) activity were used as an indicator to evaluate liver cell characteristics. Raf/MEK/ERK 5 was analyzed in hUCMSCs by Western blotting. Following FLCM treatment, expression of MSC-specific markers decreased, while hepatocyte-specific gene expression was increased. Urea production, albumin secretion, glycogen storage, and CYP3A4 activity were significantly enhanced in FLCM-treated cells. In addition, ERK1/2 phosphorylation was increased in a timedependent manner through Raf/MEK/ERK pathway, and phosphorylation was sustained at a high level during hepatic induction. Inhibition of ERK1/2 activation by U0126 (an ERK1/2 inhibitor) and pFLAG-CMV-ERK1(K71R) (negative mutant of ERK1) reversed the expression of liver-specific genes in hUCMSCs and affected hepatic function significantly. In summary, this work shows that ERK1/2 phosphorylation plays an important role in inducing hepatic differentiation of hUCMSCs in FLCM.
Moleeular confirmation of sympatric populations ofAnopheles messeae and Anopheles atroparvus overwintering in Kent, southeast England

Mosquitoes of the Anopheles maculipennis complex were collected as overwintering adults in a disused war fortification near the Cliffe marshes in the county of Kent, southeast England in January 2002. Fifty-three adult females were collected and fifty-two of these were identified as either An. atroparvus van Thiel or An. messeae Falleroni on the basis of similarity to rDNA internal transcribed spacer (ITS2) sequences in GenBank. Forty specimens (76.9«'10)were identified as An. messeae and 12 (23.1%) as An. atroparvus. DNA sequences for these species from England are provided for the first time, which enhance knowledge of the species composition and distribution ofthe An. maculipennis complex in England.
Localization and tracking of parameterized objects in point clouds

This thesis focuses on object recognition and tracking from three dimensional point cloud renderings of dense range and bearing data. Sensors like laser rangefinders and depth cameras have become increasingly popular in autonomous robotic applications. A common task is to locate and track specific objects of interest located somewhere in the point cloud. This often introduces a tedious network of heuristics to build objects from identified primitives or an intractable high dimensional search space. Through a parameterized object model and certain relaxation functions, a likelihood based view of the data can be used to accomplish these goals with increased performance and reliability. Improvements in mathematics and convergence properties have shown that this method can be realized in real time. Thesis Supervisor: John J. Leonard Title: Professor of Mechanical and Ocean Engineering
Intergroup anxiety, cultural sensitivity and socio-cultural diverse leaders’ effectiveness

This intended to analyze differences in the level of perception –of general population participants- in regards to leaders with diverse socio-cultural characteristics (gender, sexual orientation, religious affiliation, nationality) and also verify by means of structural equations, the influence of intergroup anxiety and the cultural sensitivity in terms of the level of effectiveness perception. Participants: 481 adults from Argentina (52.8% female, 47.2% male; age average = 35.45 years old). Instruments: Intergroup Anxiety scale, Cultural Sensitivity scale, and an ad hoc protocol designed to assess level of effectiveness perception in socio-culturally diverse leaders. Results: Differences in the level of perception of effectiveness according to sociocultural characteristics could not be confirmed. However, a direct effect of cultural sensitivity and an indirect effect of intergroup anxiety on the levels of effectiveness perception were confirmed. This work contributes to previous studies on prejudice and leadership.
Holographic RG flow in a new SO(3) × SO(3) sector of !-deformed SO(8) gauged N = 8 supergravity

We consider a certain N = 1 supersymmetric, SO(3) × SO(3) invariant, sub- sector of the ω-deformed family of SO(8)-gauged N = 8 four-dimensional supergravities. The theory contains two scalar fields and two pseudoscalar fields. We look for stationary points of the scalar potential, corresponding to AdS vacua in the theory. One of these, which breaks all supersymmetries but is nonetheless stable, is new. It exists only when ω 6 0. We construct supersymmetric domain wall solutions in the truncated theory, and we give a detailed analysis of their holographic dual interpretations using the AdS/CFT correspondence. Domain walls where the pseudoscalars vanish were studied previously, but those with non-vanishing pseudoscalars, which we analyse numerically, are new. The pseu- doscalars are associated with supersymmetric mass deformations in the CFT duals. When ω is zero, the solutions can be lifted to M-theory, where they approach the Coulomb-branch flows of dielectric M5-branes wrapped on S 3 in the deep IR.
Civilization: The West and the Rest

Ferguson, (2011). Civilization: The West and the Rest is an excellent book analysing the rise of Western dominance over the past five centuries. Ferguson argues that Western civilization developed six killer applications that “the Rest” lacked: 1) competition, 2) science, 3) property rights, 4) medicine, 5) consumer society, and 6) work ethic. Interestingly, Niall Ferguson, who is a professor of history at Harvard University and the London School of Economics, does not emphasize “The triumph of the West” so much as the weakness of the Rest, which, he argues, made it relatively easy for the West to consolidate its power and continue to dominate, even after 500 years. Ferguson, who is also a Senior Research Fellow of Jesus College, Oxford University and Senior Fellow of the Hoover Institution, Stanford University, takes readers on an extraordinary journey through the history of empires, pointing out significant weaknesses and strengths in some of the most important civilisations around the world – from China to the Muslim World, from the Incas in South America to the Manhattan in New York, and from Namibia in Africa to the National Assembly in France. The author of more than eleven books, dozens of articles and many television documentary series’ such as Empire, American Colossus, The War of the World, The Ascent of Money, and most recently, Civilization, asks the question of whether or not the West has lost its monopoly on these six killer applications, which underpin Western dominance. If so, Ferguson warns, Western ascendancy may be coming to an end. behaviours,